bluuebunny/crossref_metadata_2025_split huggingface dataset:
TOWARDS FUTURE ECONOMIC RESEARCH IN THE BASIN OF MEXICO
Authors: Biskowski Martin 
Published: December 2015

AbstractOngoing archaeological site destruction will limit future opportunities to conduct field research in the Basin of Mexico. Preparing for this future requires assessment of the resources that may be lost and the research that might be accomplished. Developing priorities to assist future studies of ancient economies is complicated by the evolving nature of this research. Nonetheless, trends in this research over the past few decades highlight the increasingly heavy data requirements associated with addressing economic issues. Much future research will be undercut if the required data are neither gathered nor collectable. Furthermore, many unresolved issues should be addressed while opportunities for further research remain available. The examples presented here focus on the development of the regional economy and generally reflect the author's concerns with the subsistence economy. Among these issues are characterizing more clearly the role of the site of Coapexco within the Early Formative economy, clarifying Teotihuacan's relationship with the rest of the basin when the city first achieved hegemony, and obtaining a more complete picture of the economic concerns and internal economic organization of the city. These examples represent a broader set of research issues than can be discussed in a single paper, but they illustrate the kind of work archaeologists must consider completing while they can.
TRANSLATING GODS: TOHIL AND CURICAUERI IN MESOAMERICAN POLYTHEISM IN THEPOPOL VUHAND THERELACIÓN DE MICHOACÁN
Authors: Olivier Guilhem , Martínez Roberto 
Published: December 2015

AbstractAlthough it was common in Mesoamerica to adopt foreign deities from other pantheons, less is known about the processes of “translating” foreign deities as a function of the divinities' attributes. This article analyzes the degree of intelligibility among pre-Hispanic K'iche’, P'urepecha, and Nahua peoples based on the study of patron gods Tohil and Curicaueri and their possible equivalents in the Central Highland pantheon. We can see that the search for divine homologues on the part of Mesoamerican peoples implies, beyond cultural homogeneity, an ongoing exchange of information, and recognition of the religion of the “other” based on equal standing, which tends to be a characteristic of polytheistic peoples in general.
The Multiple-Orientability Thresholds for Random Hypergraphs
Authors: FOUNTOULAKIS NIKOLAOS , KHOSLA MEGHA , PANAGIOTOU KONSTANTINOS 
Published: December 2015

Ak-uniform hypergraphH= (V, E) is called ℓ-orientable if there is an assignment of each edgee∈Eto one of its verticesv∈esuch that no vertex is assigned more than ℓ edges. LetHn,m,kbe a hypergraph, drawn uniformly at random from the set of allk-uniform hypergraphs withnvertices andmedges. In this paper we establish the threshold for the ℓ-orientability ofHn,m,kfor allk⩾ 3 and ℓ ⩾ 2, that is, we determine a critical quantityc*k,ℓsuch that with probability 1 −o(1) the graphHn,cn,khas an ℓ-orientation ifc<c*k,ℓ, but fails to do so ifc>c*k,ℓ.Our result has various applications, including sharp load thresholds for cuckoo hashing, load balancing with guaranteed maximum load, and massive parallel access to hard disk arrays.
Incomplete endothelialisation of an Amplatzer Septal Occluder device followed by meningitis and late acute bacterial endocarditis
Authors: Białkowski Jacek , Pawlak Szymon , Banaszak Paweł 
Published: December 2015

AbstractA 19-year-old woman with atrial septal defect treated percutaneously with an Amplatzer Septal Occluder 24 months earlier, who presented with a history of bacterial meningitis, was admitted with a diagnosis of endocarditis. After 6 weeks of treatment with antibiotics, the incompletely endothelialised occluder was surgically removed. The present report illustrates the need for long-term follow-up of patients who have received nitinol wire mesh occluders.
Distance from sub-Saharan Africa predicts mutational load in diverse human genomes
Authors: Henn Brenna M. , Botigué Laura R. , Peischl Stephan , Dupanloup Isabelle , Lipatov Mikhail , Maples Brian K. , Martin Alicia R. , Musharoff Shaila , Cann Howard , Snyder Michael P. , Excoffier Laurent , Kidd Jeffrey M. , Bustamante Carlos D. 
Published: December 2015

Significance
Human genomes carry hundreds of mutations that are predicted to be deleterious in some environments, potentially affecting the health or fitness of an individual. We characterize the distribution of deleterious mutations among diverse human populations, modeled under different selection coefficients and dominance parameters. Using a new dataset of diverse human genomes from seven different populations, we use spatially explicit simulations to reveal that classes of deleterious alleles have very different patterns across populations, reflecting the interaction between genetic drift and purifying selection. We show that there is a strong signal of purifying selection at conserved genomic positions within African populations, but most predicted deleterious mutations have evolved as if they were neutral during the expansion out of Africa.
Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo
Authors: Plamont Marie-Aude , Billon-Denis Emmanuelle , Maurin Sylvie , Gauron Carole , Pimenta Frederico M. , Specht Christian G. , Shi Jian , Quérard Jérôme , Pan Buyan , Rossignol Julien , Moncoq Karine , Morellet Nelly , Volovitch Michel , Lescop Ewen , Chen Yong , Triller Antoine , Vriz Sophie , Le Saux Thomas , Jullien Ludovic , Gautier Arnaud 
Published: December 2015

Significance
We developed a small protein tag enabling fluorescent labeling of proteins in living cells and in multicellular organisms through the specific binding and activation of a cell-permeant and nontoxic fluorogenic ligand. This tag, called Yellow Fluorescence-Activating and absorption-Shifting Tag (Y-FAST), was engineered by directed evolution from the Photoactive Yellow Protein. Y-FAST distinguishes itself from other labeling methods because the fluorogen binding is highly dynamic and fully reversible. Apart from providing new opportunities in superresolution imaging and biosensor design, this feature enables rapid switching on and off of the fluorescence of a fusion protein by addition or withdrawing of the fluorogenic ligand, opening exciting ways to perform sequential multiplexing imaging.
Complex pitch perception mechanisms are shared by humans and a New World monkey
Authors: Song Xindong , Osmanski Michael S. , Guo Yueqi , Wang Xiaoqin 
Published: December 2015

Significance
Complex pitch perception serves a pivotal role in human audition, especially in speech and music perception. It has been suggested that pitch perception mechanisms demonstrated in humans are not shared by nonhuman species. Here we provide evidence that a New World monkey, the common marmoset, shares all primary features of complex pitch perception mechanisms with humans. Combined with previous findings of a specialized pitch processing region in both marmoset and human auditory cortex, this evidence suggests that pitch perception mechanisms likely originated early in primate evolution.
GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression
Authors: Hua Guoqiang , Paulen Laetitia , Chambon Pierre 
Published: December 2015

Significance
Glucocorticoids (GCs), acting through binding to the GC receptor (GR), are peripheral effectors of circadian and stress-related homeostatic functions fundamental for survival throughout vertebrate life span. They are widely used to combat inflammatory and allergic disorders, and their therapeutic effects have been mainly ascribed to their capacity to suppress the production of proinflammatory cytokines. The present study unveils, at the molecular level, the mechanisms that underlie the GC-induced GR direct transrepression function mediated by the evolutionary conserved inverted repeated negative response element. This knowledge paves the way to the elucidation of the functions of the GR at the submolecular levels and to the future educated design and screening of drugs, which could be devoid of undesirable debilitating effects on prolonged GC therapy.
Mechanistic insights into c-di-GMP–dependent control of the biofilm regulator FleQ fromPseudomonas aeruginosa
Authors: Matsuyama Bruno Y. , Krasteva Petya V. , Baraquet Claudine , Harwood Caroline S. , Sondermann Holger , Navarro Marcos V. A. S. 
Published: December 2015

SignificancePseudomonas aeruginosa, an opportunistic pathogen that can cause fatal chronic infections, relies on the intracellular second-messenger c-di-GMP to form robust multicellular biofilms during host tissue colonization. c-di-GMP is sensed directly by the transcription regulator FleQ, which inversely regulates flagellar motility and exopolysaccharide secretion to secure a planktonic to sessile life-form transition. FleQ belongs to the diverse family of AAA+ ATPase enhancer-binding proteins, but how its noncanonical function on transcriptional regulation is controlled by c-di-GMP remains enigmatic. Here, we report structural and functional data that identify an unusual mode of c-di-GMP recognition accompanied by a major quaternary structure reorganization. Our analyses offer a consensus to previous studies and unique insights into the mechanism of action of FleQ and FleQ-like proteins.
Progressive forest canopy water loss during the 2012–2015 California drought
Authors: Asner Gregory P. , Brodrick Philip G. , Anderson Christopher B. , Vaughn Nicholas , Knapp David E. , Martin Roberta E. 
Published: December 2015

Significance
The state of California has a globally important economy and a population exceeding 38 million. The state relies on its forested watersheds to support numerous services, such as water provisioning, carbon storage, timber products, ecotourism, and recreation. However, secular changes in air temperature, combined with periodic and prolonged drought, pose a compounding challenge to forest health. Here we use new remote-sensing and modeling techniques to assess changes in the canopy water content of California’s forests from 2011 to 2015. Our resulting maps of progressive canopy water stress identify at-risk forest landscapes and watersheds at fine resolution, and offer geographically explicit information to support innovative forest management and policies in preparation for climate change.
Pain assessment in context: a state of the science review of the McGill pain questionnaire 40 years on
Authors: Main Chris J. 
Published: December 2015

Abstract
The McGill pain questionnaire (MPQ) and its later derivative the short form-MPQ have been used widely both in experimental and clinical pain studies. They have been of considerable importance in stimulating research into the perception of pain and now, with the publication of its latest variant, the short form-MPQ-2, it is appropriate to appraise their utility in the light of subsequent research into the nature of pain and the purpose of pain assessment. Following a description of the content and development of the questionnaires, issues of validity, reliability, and utility are addressed, not only in terms of the individual pain descriptors and the scales, but also in terms of methods of quantification. In addition, other methods of pain depiction are considered. In the second part of the review, advances in pain measurement and methodology, in the elucidation of pain mechanisms and pathways, in the psychology of pain, and in the nature of pain behavior are presented and their implications for pain assessment in general and the MPQ family of measures in particular will be addressed. It is suggested that pain assessment needs to be cast in its social context. We need to understand the influences on pain expression using a socio-communication model of pain that recognizes the function of pain and the importance of both innate pain responses and the effects of social learning. The review concludes with recommendations for future use of the MPQ and identifies a number of research challenges which lie ahead.
Chicken rRNA gene cluster structure
Authors: Demin Alexander , Koshel Elena , Saifitdinova Alsu , Galkina Svetlana , Fukagawa Tatsuo , Gaginskaya Elena 
Published: December 2015

AbstractBackgroundRepeated clusters of ribosomal genes whose activity results in the nucleolus formation are extremely important in multicellular organism genome. Despite the extensive exploration into vertebrate genomes, in many model objects the ribosomal cluster structure is still underinvestigated. So far, complete description for primary structure of avian ribosomal cluster has not been reported.ResultsThis work represents the first successful assembly of complete chicken ribosome cluster sequence. The sequence was deposited to GenBank under accession numberKT445934.The total cluster size frompre-rRNAtranscriptional start site to the 3′ end of3’ETSamounted to 11444 bp.18S rRNAgene size is 1823 base pairs,5.8S rRNA –157 bp,28S rRNA –4443 bp. The5 ‘ETSspacer core size is 1839 bp,3’ETS –about 350 bp.,ITS1 –2099 bp, andITS2 –733 bp. The assembly was validated throughin situfluorescent hybridization (FISH) analysis on metaphase chromosomes of chicken.ITS1andITS2spacer sequences have been found to have high GC pair content and form secondary structures featuring high melting temperature.ConclusionsDecoding of the chicken rRNA gene cluster sequence extends the use of birds as a model object for exploration into nucleolus organizer region (NOR) regulation and nucleolus functions, e.g. in ontogenesis. This data might also be useful to address certain problems of population and evolutionary genetics.
Nectar accessibility determines fitness, flower choice and abundance of hoverflies that provide natural pest control
Authors: van Rijn Paul C. J. , Wäckers Felix L. 
Published: December 2015

Summary

In modern agricultural landscapes, many organisms providing ecosystem services such as pollination and natural pest control are likely constrained by shortage of nectar and/or pollen required for adult nutrition. More and more flower‐rich field margin strips and other habitats are created to eliminate these constraints. For most target organisms, however, it is not well known which (types of) flowers are effective in providing suitable pollen and nectar.

We studied the suitability of a wide range of flowers as a food source for zoophagous hoverflies (hoverflies with predatory larvae) at five different levels: nectar accessibility (based on flower morphology), realized adult fitness, flower choice (both based on cage experiments), flower visitation and hoverfly abundance in mixed vegetation (both based on field observations).

Realized survival of Episyrphus balteatus is related to effective flower depth by a sigmoid function. The critical flower depth is 1·6 mm, which is less than the proboscis size of the hoverfly. For Asteraceae, the critical floret depth is even less than 1·0 mm, which – in contrast to common knowledge – rules out most species within this family.

Both flower choice in the laboratory and flower visitation rates in the field are well correlated with nectar accessibility and realized adult survival.

In mixed floral vegetation, the number of zoophagous hoverflies is highly correlated with the abundance of only those flowers that have accessible nectar for these hoverflies.

Synthesis and applications. This comparative study demonstrates that nectar (and not pollen) accessibility is the main driver determining flower resource suitability, flower choice and abundance of zoophagous hoverflies in arable field margins. The study identifies the limited range of plant species that can effectively support these beneficial insects. Preserving the right flowers in and around agricultural fields could enhance local populations and the pest control and pollination services they provide.
Hypoxia inducible factor‐1α inhibition produced anti‐allodynia effect and suppressed inflammatory cytokine production in early stage of mouse complex regional pain syndrome model
Authors: Hsiao Hung‐Tsung , Lin Ya‐Chi , Wang Jeffrey Chi‐Fei , Tsai Yu‐Chuan , Liu Yen‐Chin 
Published: December 2015

SummaryComplex regional pain syndrome (CRPS) is related to microcirculation impairment associated with tissue hypoxia and peripheral cytokine overproduction in the affected limb. Previous studies suggest that the pathogenesis involves hypoxia inducible factor‐1α (HIF‐1α) and exaggerated regional inflammatory response. 1‐methylpropyl 2‐imidazolyl disulfide (PX‐12) acts as the thioredoxin‐1 (Trx‐1) inhibitor and decreases the level of HIF‐1α, and can rapidly be metabolized for Trx‐1 redox inactivation. This study hypothesized that PX‐12 can decrease the cytokine production for nociceptive sensitization in the hypoxia‐induced pain model. CD1 mice weighing around 30 g were used. The animal CRPS model was developed via the chronic post‐ischaemic pain (CPIP) model. The model was induced by using O‐rings on the ankles of the mice hind limbs to produce 3‐h ischaemia–reperfusion injury on the paw. PX‐12 (25 mg/kg, 5 mg/kg) was given through tail vein injection immediately after ischaemia. Animal behaviour was tested using the von Frey method for 7 days. Local paw skin tissue was harvest from three groups (control, 5 mg/kg, 25 mg/kg) 2 h after injection of PX‐12. The protein expression of interleukin‐1β (IL‐1β) and HIF‐1α was analysed with the Western blotting method. Mice significantly present an anti‐allodynia effect in a dose‐related manner after the PX‐12 administration. Furthermore, PX‐12 not only decreased the expression of HIF‐1α but also decreased the expression of IL‐1β over the injured palm. This study, therefore, shows the first evidence of the anti‐allodynia effect of PX‐12 in a CPIP animal model for pain behaviour. The study concluded that inhibition of HIF‐1α may produce an analgesic effect and the associated suppression of inflammatory cytokine IL‐1β in a CPIP model.
Word reading aloud skills: their positive redefinition through ageing
Authors: Chapleau Marianne , Wilson Maximiliano A. , Potvin Karel , Harvey‐Langton Alexandra , Montembeault Maxime , Brambati Simona M. 
Published: December 2015

BackgroundSuccessful reading can be achieved by means of two different procedures: sub‐word processes for the pronunciation of words without semantics or pseudowords (PW) and whole‐word processes that recruit word‐specific information regarding the pronunciation of words with atypical orthography‐to‐phonology mappings (exception words, EW).MethodsWe compared reading abilities between 35 young and 35 older adults in an experimental reading task including low‐frequency regular (RW), EW and PW.ResultsA significant effect of word type, group and an interaction word type by group was found for errors. Young adults made significantly more regularization errors than older subjects for EWs. Conversely, young readers read PW and RW significantly faster. These results indicate that older adults compared with younger adults are more accurate when reading low‐frequency EW.ConclusionThe fact that young adults were faster than the elderly for PW and RW reading, together with a larger number of regularization errors in EW reading, suggests that they relied on sub‐word processes to a larger extent than the older group.HighlightsWhat is already known about this topic:

Sub‐word processes are based on the use of consistent or regular orthography‐to‐phonology mappings that represent the sub‐units that compose words and are mainly used for pseudoword reading.
Whole‐word processes use item‐specific information regarding the pronunciation of a particular word and are mainly used for exception word reading.
During reading acquisition, and as reading experience increase, children switch from sub‐word processing strategies to a more efficient use of whole‐word processes.
What this paper adds:

The ability to read exception words continues to improve over the lifespan, even in later stages of life.
Elderly adults rely on whole‐word processes to a larger extent than younger adults.
Implications for theory, policy or practice:

These results contrast with the general idea that ageing is associated with general cognitive decline, so older people should be encouraged to engage in reading activities.
The fact that this cognitive ability is improved during ageing could provide insightful information for developing intervention programmes in patients with acquired reading disorders.
Assessing the fetal effects of maternal obesity via transcriptomic analysis of cord blood: a prospective case–control study
Authors: Edlow AG , Hui L , Wick HC , Fried I , Bianchi DW 
Published: December 2015

ObjectiveTo analyse fetal gene expression at term using umbilical cord blood, in order to provide insights into the effects of maternal obesity on human development.DesignProspective case–control study.SettingAcademic tertiary care centre.PopulationEight obese (body mass index ≥30 kg/m2) and eight lean (body mass index <25 kg/m2) pregnant women undergoing prelabour caesarean delivery at term.MethodsWomen were matched for gestational age and fetal sex. Cord blood RNA was extracted and hybridised to gene expression arrays. Differentially regulated genes were identified using paired t‐tests and the Benjamini–Hochberg correction. Functional analyses were performed using Ingenuity Pathway Analysis, BioGPS and Gene Set Enrichment Analysis with a fetal‐specific annotation. Z‐scores ≥2.0 or P‐values <0.01 were considered significant.Main outcome measureFunctions of differentially regulated genes in fetuses of obese women.ResultsA total of 701 differentially regulated genes were identified, producing an expression profile implicating neurodegeneration, decreased survival of sensory neurons, and decreased neurogenesis in the fetuses of obese women. Upstream regulators related to inflammatory signalling were significantly activated; those related to insulin receptor signalling, lipid homeostasis, regulation of axonal guidance, and cellular response to oxidative stress were significantly inhibited. Of 26 tissue‐specific genes that were differentially regulated in fetuses of obese women, six mapped to the fetal brain.ConclusionMaternal obesity affects fetal gene expression at term, implicating dysregulated brain development, inflammatory and immune signalling, glucose and lipid homeostasis, and oxidative stress. This may have implications for postnatal neurodevelopment and metabolism.Tweetable abstractFetal cord blood transcriptome in obese women suggests neurodevelopmental and metabolic programming effects.