bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Piano for Visuals: Affordances of Scan Processing Instruments
Authors: Holzer Derek 
Published: October 2024

Abstract
The analog technology of scan processing was developed and used during the 1970s as a method of electronic image animation. Because their real time modes of operation strongly resemble those of electronic musical instruments, scan processors can be considered instruments with which to compose and play moving images. Although cheaper digital tools replaced them in commercial studios during the 1980s, scan processing has a distinctive aesthetic that continues to inspire both visual artists and instrument designers. This article examines the way that scan processing instruments’ affordances arise from specific combinations of the user, technology, and situation by surveying a number of technical and artistic use cases involving two different instruments: the VP-8 Image Analyzer and the Rutt/Etra Video Synthesizer. The article also demonstrates how reenacting an instrument works through its historical affordances using current technological means to address present-day contexts.
Justice, Equity, and Approaches for Sharing Benefits from Deep Sea Mining Operations in the Area
Authors: Friedman Shani 
Published: October 2024

Abstract
This article critically examines the current benefit-sharing regime on the international seabed (the Area) and the proposed modalities for benefit-sharing. The United Nations Convention on the Law of the Sea contains few and vague rules on this issue. The only obligation is that benefit-sharing should be ‘equitable’ and the interests of developing States must be considered. To determine what may constitute equitable sharing the practice of other law of the sea legal regimes are examined and proposed distribution mechanisms are critically analysed. The article offers a unique perspective by trying to identify the scope of the vague equitable criterion for sharing or distributing benefits, rather than referring to it as a general goal or principle. Doing so, the article offers a practical account for the feasibility of different distribution modalities, which may yield new insights for institutional design to better deal with challenges in this well-researched but still unclear issue.
Transcriptomic response of Hermetia illucens L. (Diptera: Stratiomyidae) to wounding and Gram-negative bacterial infection
Authors: Shah P.N. , Maistrou S. , Willemsen I. , van Loon J.J.A. , Dicke M. 
Published: October 2024

Abstract
The larvae of the black soldier fly (BSFL), Hermetia illucens L. (Diptera: Stratiomyidae), are of economic interest due to their use as livestock feed component. Unraveling their response to a bacterial infection will allow us to gain a better insight into their biology. In the current study, we used RNA-Seq analysis to unravel the transcriptomic response of BSFL to wounding and infection by a Gram-negative bacterium, Pseudomonas protegens Pf-5. Five-day-old BSFL were subjected to three treatments, i.e. untreated, PBS-injection, and bacteria-injection (5000 CFU per larva) and samples were collected at three time points (2 h, 6 h, and 13 h) post- treatment. Wounding induced expression of genes encoding recognition molecules and signaling pathway genes such as PGRP-SA, and Relish, and antimicrobial peptides (AMPs) such cecropin, defensin, and attacin. At 2 h, wounding resulted in a significant upregulation of immunity-related genes whereas genes encoding for resilin and cuticle proteins were significantly downregulated. At 6 h, the expression of immunity-related genes reduced in response to wounding whereas their expression increased in infected larvae. At 13 h, the expression of immunity-related genes reduced drastically in response to wounding, while their expression increased significantly in infected larvae. Conversely, the expression of metabolism-related genes, such as trypsin and chymotrypsin, was significantly upregulated in wounded larvae at 13 h, while their expression was significantly reduced in infected larvae. Increased investments in immunity-related processes in infected BSF larvae correlated with the downregulation of genes associated with metabolic processes indicative of a trade-off. Various immunity-related genes, including those encoding cecropin, defensin, attacin, and PGRP-SA, were consistently induced only during pathogen infection, indicating their role in immunity against Gram-negative bacteria. In this study, we report multiple genes that are significantly upregulated post-bacterial infection in BSFL that may be utilized as biomarkers to monitor insect health in mass production facilities.
Improving egg quality in laying hens using calcium salt of black soldier fly larvae oil
Authors: Anas M.A , Aprianto M.A. , Muhlisin M. , Kurniawati A. , Hanim C. , Budiariati V. , Montha N. 
Published: October 2024

Abstract
Black soldier fly larvae (BSFL) oil has gained attention as a potential substitute for vegetable oil in feed formulations designed to improve productivity and product quality. This study aimed to investigate the impact of supplementation BSFL oil calcium salt (BSFLO-SCa) on the egg quality and gene expression involved in fat metabolism in laying hens. A total of sixty 40-wk-old ISA Brown laying hens were divided into three distinct groups: a control group (T0) that received a basic diet, and two treatment groups that were supplemented with 1% (T1) and 2% (T2) BSFLO-SCa. Each group consisted of 5 replicates, with 4 laying hens per replicate. The study indicated that the inclusion of 2% of BSFLO-SCa significantly increased egg albumen weight, height, ratio, eggshell weight, and thickness (). The inclusion of 1 and 2% of BSFLO-SCa increased the yolk lightness (L*) and yellowness (b*), but redness (a*) was decreased (). Moreover, BSFLO-SCa supplementation with 1 and 2% reduced () egg fat and cholesterol. Analysis of fatty acid profiles showed significantly increased medium-chain fatty acid (MCFA) and polyunsaturated fatty acid (PUFA) (), while monosaturated fatty acid (MUFA) reduced () with 2% BSFLO-SCa. Gene expression related to lipid metabolism, such as fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), as well as cholesterol synthesis gene expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) were downregulated (). In conclusion, the inclusion of 2% BSFLO-SCa in the diet improved quality and reduced fat and cholesterol content in eggs from laying hens. This improvement was accompanied by downregulation of key genes involved in lipid metabolism.
Innocence and Knowledge Acquisition: Epiphanies of Knowledge in Olga Tokarczuk’s “Podróż Ludzi Księgi” [The Journey of the Book-People]
Authors: Kazibut Agnieszka , Kazibut Radosław 
Published: October 2024

Innocence and Knowledge Acquisition: Epiphanies of Knowledge in Olga Tokarczuk’s Podróż Ludzi Księgi [The Journey of the Book-People]
The Journey and the Book are the hidden but central characters in Olga Tokarczuk’s debut novel, Podróż ludzi Księgi [The Journey of the Book-People] (1993). In Tokarczuk’s novel, the three dimensions of the journey correspond to the material, the psychological, and the esoteric religious. This paper identifies and discusses these interrelated planes of Tokarczuk’s story.

Niewinność i poznanie. Epifanie wiedzy w Podróży ludzi Księgi Olgi Tokarczuk
Podróż i Księga to ukryci, ale główni bohaterowie debiutanckiej powieści Olgi Tokarczuk Podróż ludzi Księgi (1993). W powieści tej korespondują trzy wymiary wędrówki: materialny, psychologiczny oraz ezoteryczno-religijny. W artykule te trzy powiązane ze sobą płaszczyzny opowieści zostały zidentyfikowane i przedyskutowane.
Beyond Morbidity and Mortality Conference: How Do We Learn From Special Cases?
Authors: Cohen Michael B. , Garvey Emily A. , Kohn Jocelyn L. , Setzen Sean A. , Grundfast Kenneth M. , Platt Michael P. 
Published: October 2024

Objective: Physicians experience scary cases in the course of usual medical practice. Cases of near misses, legal and ethical dilemmas, or unique clinical challenges are great sources of education. However, there is no format for presentation and dissemination of cases that do not meet criteria for morbidity and mortality (M&M) conferences. The Scary Cases Conference is an innovative educational forum for scrutiny and analysis of these challenging clinical cases. Scary Cases differs from traditional Morbidity and Mortality conferences as it explores outcomes beyond the scope of medical or surgical errors. Methods: From 2011 to 2021: 11 regional and 10 national “Otolaryngology Scary Cases” conferences and mini-seminars were held. The cases presented were analyzed for case specialty, area of management deemed troublesome, and compared to M&M conference criteria. Results: 187 cases were presented. 62% percent of cases included traditional medical problems, whereas 21% involved legal issues, and 17% focused on ethical dilemmas. For the cases with medical problems, 31% involved airway obstruction, 17% nerve injuries, and 17% malignancy. 49% of cases would have met criteria for presentation at traditional M&M conferences. Of all the “scary cases,” 25% were near misses and 26% represented ethical or legal dilemmas which would not be classified as morbitidy, mortality, or near miss. Conclusions: The Scary Cases provides a forum conducive to learning amongst peers and experts. It allows medical and surgical specialties to share the cases deemed most impactful. The M&M conference would only include half of such cases, but could be expanded beyond the traditional scope in the future.
Understanding Alcohol and Illicit Drug Use in Young College Students: A Qualitative Work from India Based on Social Norms Theory
Authors: Ghosh Abhishek , George Blessy B. , Vij Jatina , Pillai Renjith R. , Soundappan Kathirvel , Sharma Mamta , Basu Debasish 
Published: October 2024

Background and Objectives: Substance use among young college students in India poses public health challenges. This study seeks to uncover the motivation behind alcohol and illicit drug consumption, applying social norms theory. Methods: This qualitative research utilized the framework method to analyze data from 14 college students (18–24 years) across various disciplines. Participants were selected using purposive sampling to ensure diversity in demographics and perspectives. Data collection was conducted online. The study used a combination of in-depth interviews (n = 14) and focused group discussions (n = 2). We used AtLAS.ti to facilitate data analysis. We used a mixed inductive and deductive coding approach. A mind map was generated to visualize the complex interplay between social norms and other individual and external mediators. Results: We identified 10 themes, 20 subthemes, and 42 codes. The themes revealed descriptive (e.g., media and modernization) and injunctive (e.g., availability and legality) social norms that facilitate substance use and social disapproval and stigma that might deter young people from using substances. Family and institutional support were also found to play a protective role. The individuals also weigh the personal consequences (e.g., health and academic harm) and advantages (e.g., coping and relaxation) of substance use, which can influence their decision to use substances. Gendered norms and subtle differences in the social norms between alcohol and illicit drugs were also identified. Conclusion: Our study illuminates culturally tailored substance use prevention/intervention strategies that operate at the social, individual, and policy levels.
Evaluation of Frontal QRS-T Angle in Children With ADHD and Healthy Controls
Authors: Kılıçaslan Fethiye , Tan Aybike , Tanriverdi Zulkif 
Published: October 2024

Introduction: Conflicting findings exist regarding the link between attention deficit hyperactivity disorder (ADHD) and cardiovascular diseases. This study aimed to evaluate the frontal QRS-T (fQRS-T) angle and its correlation with symptom severity in children diagnosed with ADHD. Methods: The study population consisted of 172 patients diagnosed with ADHD (120 drug naive and 52 drug positive) and 82 healthy controls. ADHD symptoms were assessed using the Atilla Turgay DSM-IV-Based Screening and Assessment Scale for Disruptive Conduct Disorders (T-DSM-IV-Scale). The fQRS-T angle and corrected QT (QTc) interval were obtained from the automated reports of 12-lead electrocardiography device for each patient. Results: QTc interval and fQRS-T angle were significantly different among the groups. Post hoc analyses showed that QTc interval and fQRS-T angle of ADHD drug naive and ADHD drug positive patients were significantly higher than the healthy control groups. However, there was no significant difference between drug naive and drug positive patients regarding QTc interval and fQRS-T angle. Both QTc interval and fQRS-T angle showed positive correlations with the severity of ADHD symptoms (r = 0.263, p = .001 and r = 0.175, p = .023 respectively). Conclusion: We found that fQRS-T angle was significantly wider in children with ADHD. Therefore, we suggest that fQRS-T angle may help in cardiovascular risk assessment in children with ADHD.
Higher hair cortisol levels associated with previous cardiovascular events and cardiovascular risks in a large cross-sectional population study
Authors: Faresjö Åshild , Theodorsson Elvar , Stomby Andreas , Quist Helena , Jones Michael P. , Östgren Carl Johan , Dahlqvist Per , Faresjö Tomas 
Published: October 2024

Abstract
Background
Stress is today a common feature of patients seeking medical care and a growing public health issue in society. A method has been developed to measure biological chronic stress by Hair Cortisol Concentrations (HCC). This biomarker, for chronic stress, captures information about cumulative cortisol levels over the course of several months. Long-term stress might be one of the factors contributing to the onset of cardiovascular conditions and also affecting different risk factors. The aim of this study was to analyse the association between Hair Cortisol Concentrations and previous cardiovascular diseases and cardiovascular risk factors.

Methods
The method of measuring chronic stress by Hair Cortisol Concentration was applied in a large Swedish national observational cross-sectional study. A population-based random sample of N = 4,821 Swedish middle-aged men and women was analysed for hair cortisol levels in relation to diagnosed previous cardiovascular diseases and biologically measured cardiovascular risk factors.

Results
Long-term stress, measured by hair cortisol, was significantly associated with the classical cardiovascular risk factors hypertension and high cholesterol, but not smoking. Those with elevated HCC levels also had a significantly increased pre-history of myocardial infarction, type 2 diabetes, atrial fibrillation and by-pass surgery, but not regarding stroke, angina pectoris or sleep apnoea. Higher HCC was significantly associated (p < 0.001) with Body mass index and waist circumference, but only for females. HCC was also associated with the risk markers leukocytes, and high-sensitivity CRP, indicating a possible linkage between HCC and inflammation and hypothetically also the bodily immune defense. No association was found between perceived stress and HCC.

Conclusions
An overall conclusion of our results is that health care should put more emphasis on patients reporting that they have been exposed to long term stress. Altogether, these analyses of Hair cortisol levels in a large middle-aged population show that chronically elevated cortisol levels represent a relevant and significant factor associated with cardiovascular diseases and classical cardiovascular risk factors.
Daily snuff use during pregnancy, gestational length and birth weight; register-based study
Authors: Lie Rolv T. , Magnus Maria C. , Gjessing Håkon K. , Wilcox Allen J. , Håberg Siri E. 
Published: October 2024

Abstract
Background
Snuff is a smokeless source of nicotine that is common in Scandinavia and increasingly used by women of fertile age. Persistent use of snuff during pregnancy has been associated with adverse pregnancy outcomes. Emerging data from the Medical Birth Registry of Norway distinguishes between occasional use and daily use. We provide preliminary estimates of associations between frequency of snuff and gestational length and birth weight.

Methods
Data on snuff use during pregnancies delivered in 2020 and 2021 were available for the west and central regions of Norway. Associations of snuff use with gestational length and birth weight at term (39–41 weeks) were estimated using quantile regression at the 25th, the 50th and the 75th percentiles, with adjustments for mother’s age, pre-pregnancy weight, and parity. We compared associations with the pregnancy outcomes according to maternal snuff and cigarette use.

Results
12.4% of 18 042 non-smoking women reported daily use of snuff before pregnancy, and 4.6% reported continuing use during pregnancy, with 1.2% still reporting daily use in the last trimester. Women with daily use through the last trimester delivered babies with a median gestational length reduced by 3.4 days (95% CI: -5.0 to -1.7 days) compared with women who never used snuff. The reduction was even stronger at the 25th percentile of gestational age. The median term birth weight was reduced by 44 g (95% CI: -134 to 46 g). These associations were much weaker for women who quit snuff at some point during pregnancy or used snuff only occasionally. Mothers who smoked daily through the last trimester had a median gestational length reduced by 2.1 days (95% CI: -2.7 to -1.4) and a median term birth weight reduced by 294 g (95% CI: -325 to -262) compared with never-smokers.

Conclusions
Daily snuff use through the last trimester reduced the median gestational length by more than three days. Snuff reduced birth weight, but not as much as smoking, suggesting that the predominant effect of smoking on fetal growth is not through nicotine but through the additional toxic chemicals in cigarettes or by reduced oxygen supply to the fetus.
Marginal bone loss and soft tissue health around two-implant mandibular overdenture retained with milled versus selective laser melted cobalt chromium bar: a randomized clinical trial
Authors: El-Asfahani Iman Adel , Abd El-Moatty Reem , Mohamed Gehan Fekry , Hussein Hussein Abdelhady 
Published: October 2024

Abstract
Background
To assess marginal bone loss and soft tissue health around two-implant mandibular overdenture retained with milled versus selective laser-melted cobalt chromium (Co-Cr) bars.

Method
This research was set to be a parallel, triple-blinded, randomised controlled trial. Twenty completely edentulous patients received new conventional complete dentures according to conventional techniques. Two implants were placed at mandibular canine areas bilaterally, and patients were randomly allocated into two equal groups: the milled Co-Cr bar group and the selective laser melted (SLM) Co-Cr bar group. Marginal bone loss (MBL), modified plaque index (mPI), modified gingival index (mGI), and probing depth (PD) were evaluated at 0-month (baseline), 6-month, and 12-month follow-up visits. Repeated measures ANOVA test and Bonferroni’s post-hoc test were used for parametric data as PD, while for non-parametric data as MBL, mGI, and mPI, Mann-Whitney U test and Friedman’s test were used. A P-value ≤ 0.05 was set as the statistical level of significance. The study protocol was approved by the Faculty Research Ethics Committee at Minia University (636 4/10/2022). Registration for the clinical trial was made retrospectively on clinicaltrials.gov with ID NCT06401200 at 04/30/2024.

Results
The follow-up period (one year) was completed without a dropout. Regarding MBL, no statistically significant difference was found between the two groups throughout the study. However, the milled group showed significantly increased MBL from 0- to 6-month follow up period. In both groups, mPI increased significantly from 0- to 6-months post-loading. On the other hand, no statistically significant difference between the two groups was found regarding mPI and mGI throughout the study follow-up periods. The PD was significantly lower in the milled compared to the SLM group at the 6- and 12-month follow up period.

Conclusion
Two-implant mandibular overdenture retained with milled or SLM Co-Cr bar can provide an acceptable treatment option for completely edentulous patients regarding marginal bone loss and soft tissue outcomes.
Effects of mandarin peel powder on growth, biochemical, immune, and intestinal health in Oreochromis niloticus at suboptimal temperatures
Authors: Reda Rasha M. , El-Rahim Mostafa I. Abd , Elkerdawy Dawlat A. , Metwally Mohamed M. M. , Said Nermin 
Published: October 2024

AbstractThis 60-day study aimed to examine the efficacy of a diet supplemented with mandarin peel powder (MP) in enhancing the health and survival of Oreochromis niloticus under suboptimal temperature conditions (21 ℃). One hundred and eighty Nile tilapia fish (22.51 ± 0.04 g) were randomly distributed into four experimental groups; each of 3 replicates (15 fish per replicate). The first group (CONT) received a basal diet without MP. The second (MP10%), third (MP15%), and fourth (MP20%) groups were fed diets containing 10, 15, and 20% MP powder, respectively. At the end of the feeding trail, growth performance, serum growth hormone, α-amylase enzyme, lysozyme activity, nitric oxide, protease activity, globulin, serum levels of IL-1ß, antioxidant status, and intestinal histology were measured. The results showed insignificant differences between CONT, MP15%, and MP20% groups in the final body weight and specific growth rate. The growth hormones in the MP15% and MP20% groups did not show a significant difference compared to fish fed a normal basal diet (CONT). However, the amylase enzymes were significantly greater in both groups. The MP20% and MP15% groups showed a significant increase in antioxidant, lysozyme, nitric oxide, and protease activities compared to CONT. The results also showed that fish that were fed a diet with MP had significantly less of the pro-inflammatory cytokine interleukin-1 beta, and their intestinal villi got wider, especially in the MP20% group. It could be concluded that feeding tilapia on a diet with 20% MP is an effective strategy to improve their health when the temperature is below 21 °C. This is because the fish exhibit higher levels of antioxidant activity, reduced pro-inflammatory responses, and improved intestinal health without difference in the growth performance in compared to control group.