bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population-based Relative Risks for Specific Family History Constellations of Breast Cancer
Authors: Albright Frederick S. , Kohlmann Wendy , Neumayer Leigh , Buys Saundra S. , Matsen Cindy B. , Kaphingst Kimberly A. , Cannon-Albright Lisa A. 
Published: May 2017

AbstractPurposeUsing a large resource linking genealogy with decades of cancer data, RRs were estimated for breast cancer (BC) based on specific family history extending to first cousins.MethodsRRs for BC were estimated in 640,366 females with breast cancer family histories that included number of first-(FDR), second-(SDR), and third-degree relatives (TDR), maternal and paternal relatives, and age at earliest diagnosis.ResultsRRs for first-degree relatives of BC cases ranged from 1.61 (=1 FDR affected, CI: 1.56, 1.67) to 5.00 (≥4 FDRs affected, CI: 3.35, 7.18). RRs for second degree relatives of probands with 0 affected FDRs ranged from 1.08 (≥1 SDR affected, CI: 1.04, 1.12) to 1.71 (≥4 SDRs affected, CI: 1.26, 2.27) and for second degree relatives of probands with exactly 1 FDR from 1.54 (0 SDRs affected, CI:1.47, 1.61) to 4.78 (≥ 5 SDRs; CI 2.47, 8.35). RRs for third-degree relatives with no closer relatives affected were significantly elevated for probands with >=5 affected TDRs RR=1.32, CI: 1.11, 1.57).ConclusionsThe majority of females analyzed had a family history of BC. Any number of affected FDRs or SDRs significantly increased risk for BC, and more than 4 TDRs, even with no affected FDRs or SDRs significantly increased risk. Risk prediction derived from specific and extended family history allows identification of females at highest risk even when they do not have a conventionally defined “high risk” family; these risks could be a powerful, efficient tool to individualize cancer prevention and screening.
Parallel sequencing lives, or what makes large sequencing projects successful
Authors: Quilez Javier , Vidal Enrique , Dily François Le , Serra François , Cuartero Yasmina , Stadhouders Ralph , Graf Thomas , Marti-Renom Marc A. , Beato Miguel , Filion Guillaume 
Published: May 2017

AbstractT47D_rep2 and b1913e6c1_51720e9cf were two Hi-C samples. They were born and processed at the same time, yet their fates were very different. The life of b1913e6c1_51720e9cf was simple and fruitful, while that of T47D_rep2 was full of accidents and sorrow. At the heart of these differences lies the fact that b1913e6c1_51720e9cf was born under a lab culture of Documentation, Automation, Traceability, Autonomy and compliance with the FAIR Principles. Their lives are a lesson for those who wish to embark on the journey of managing high throughput sequencing data.
Population-Averaged Atlas of the Macroscale Human Structural Connectome and Its Network Topology
Authors: Yeh Fang-Cheng , Panesar Sandip , Fernandes David , Meola Antonio , Yoshino Masanori , Fernandez-Miranda Juan C , Vettel Jean M. , Verstynen Timothy 
Published: May 2017

AbstractA comprehensive map of the structural connectome in the human brain has been a coveted resource for understanding macroscopic brain networks. Here we report an expert-vetted, population-averaged atlas of the structural connectome derived from diffusion MRI data (N=842). This was achieved by creating a high-resolution template of diffusion patterns averaged across individual subjects and using tractography to generate 550,000 trajectories of representative white matter fascicles annotated by 80 anatomical labels. The trajectories were subsequently clustered and labeled by a team of experienced neuroanatomists in order to conform to prior neuroanatomical knowledge. A multi-level network topology was then described using whole-brain connectograms, with subdivisions of the association pathways showing small-worldness in intra-hemisphere connections, projection pathways showing hub structures at thalamus, putamen, and brainstem, and commissural pathways showing bridges connecting cerebral hemispheres to provide global efficiency. This atlas of the structural connectome provides representative organization of human brain white matter, complementary to traditional histologically-derived and voxel-based white matter atlases, allowing for better modeling and simulation of brain connectivity for future connectome studies.
FplA FromFusobacterium nucleatumis a Type Vd autotransporter phospholipase with a proposed role in altered host signaling and evasion of autophagy
Authors: Casasanta Michael A. , Yoo Christopher C. , Smith Hans B. , Duncan A. Jane , Cochrane Kyla , Varano Ann C. , Allen-Vercoe Emma , Slade Daniel J. 
Published: May 2017

ABSTRACTFusobacterium nucleatumis a pathogenic oral bacterium that is linked to multiple human infections and colorectal cancer. While most Gram-negative pathogens utilize secretion systems for cellular invasion and infection,F. nucleatumlacks Type I, II, III, IV, and VI secretion. By contrast,F. nucleatumstrains are enriched in Type V secreted autotransporters, which are Gram-negative bacterial virulence factors critical for binding and entry into host cells. Here we present the first biochemical characterization of aF. nucleatumType Vd phospholipase class A1 autotransporter (strain ATCC 25586, gene FN1704) that we hereby renameFusobacteriumphospholipase autotransporter (FplA). FplA is expressed as a full-length 85 kDa outer membrane embedded protein, or as a truncated phospholipase domain that remains associated with the outer membrane. Using multiple FplA constructs we characterized lipid substrate specificity, potent inhibitors, and chemical probes to detect and track this enzyme family. While the role of FplA is undetermined inF. nucleatumvirulence, homologous phospholipases from intracellular pathogens are critical for vacuole escape, altered host signaling, and intracellular survival. We hypothesize that upon intracellular invasion of the host, FplA could play a role in phagosomal escape, subversion of autophagy, or eicosanoid-mediated inflammatory signaling, as we show that FplA binds with high affinity to host phosphoinositide signaling lipids critical to these processes. Our identification of substrates, inhibitors, and chemical probes for FplA, in combination with anfplAgene deletion strain, encompass a powerful set of tools for the future analysis of FplAin vivo. In addition, these studies will guide the biochemical characterization of additional Type Vd autotransporter phospholipases.IMPORTANCEF. nucleatumis an emerging pathogen that is linked to the pathogenesis of colorectal cancer, yet there is a critical knowledge gap in the mechanisms used by this bacterium to elicit changes in the host for intracellular entry and survival. As phospholipases are critical virulence factors for intracellular bacteria to initiate vacuole lysis, cell-to-cell spread, and evasion of autophagy, we set out to characterize a unique Type Vd secreted phospholipase A1 enzyme fromF. nucleatum. Our results show a potential role for modulating host signaling pathways through cleavage of phosphoinositide dependent signaling lipids. These studies open the door for further characterization of this unique enzyme family in bacterial virulence, host-pathogen interactions, and forF. nucleatum, in colorectal carcinogenesis.
Application of the analytical hierarchy process to evaluate consumer acceptance and preferences for omega-3 enriched eggs
Authors: Baba Yasmina , Kallas Zein , Realini Carolina 
Published: May 2017

Purpose
The purpose of this paper is to analyse the appropriateness of the analytical hierarchy process (AHP) to measure consumers’ acceptance and preference for eggs enriched with omega-3 (n-3) fatty acids as a health claim and to compare its results with the traditional nine-point hedonic scale.

Design/methodology/approach
The AHP was used as a multi-criteria decision analysis. Data were obtained from a face-to-face questionnaire completed by 122 consumers in a controlled environment in Cataluña (Spain).

Findings
Results showed the capacity of the AHP to analyse consumers’ acceptance and preferences. An agreement between the AHP and the nine-point scale was found showing that n-3 enriched eggs had lower flavour acceptance, conventional eggs had higher yolk colour acceptance, and conventional and the free-range eggs had similar and higher odour acceptance than the other egg types. The most important attributes that determine preferences for egg purchase were the type and the egg price followed by the origin and the egg size.

Research limitations/implications
The AHP approach seems to be a reliable tool to evaluate consumers’ hedonic preferences. However, further testing on other food products with larger sample size is needed.

Originality/value
The AHP methodology has been widely used in many fields in the last decades, but to the knowledge, not in the sensory field. In the Spanish market, studies that analyse consumers’ preferences and acceptance of eggs are scarce, and new insights are needed particularly regarding n-3 enriched eggs.
Quality preferences and pricing of fresh-cut salads in Italy: new evidence from market data
Authors: Pilone Vittoria , Stasi Antonio , Baselice Antonio 
Published: May 2017

Purpose
In Europe fresh-cut fruit and vegetables, is one of the major growing segments in agro-food sector. Current literature reports a limited number of studies about consumers’ preferences towards these products. In particular, it lacks of studies focussed on fresh-cut salads and based on market data. In this paper, a study on consumer preferences towards the main attributes of Italian fresh-cut salads is proposed. More specifically the investigation is focussed on attributes assessable by consumers before purchase such as assortment, tenderness, product preparation and vegetable variety together with brand, size and type of packaging, presence of organic certification, promotion and product price. The purpose of this paper is to evaluate how much Italian consumers pay for those attributes with the aim to understand how much profitable could be different strategies in the sector.

Design/methodology/approach
The analysis is based on IRI-Infoscan scanner data, consisting of 881 fresh-cut products. The impact of each attributes on pricing is measured by means of a hedonic price model.

Findings
Main results show that, in Italy, fresh-cut salad price is greatly affected by tenderness, product preparation, assortment, brand, presence of organic certification, packaging attributes and vegetable variety.

Practical implications
Findings offer to producers the possibility to set up products by composing the mix of attributes that gives back the highest price. In addition, they provide some insights to define manufacturer’s strategies.

Originality/value
This paper represents a novelty in economic literature because it can be considered an example of consumer preferences analysis towards the different attributes of fresh-cut vegetables based on real market data.
Components of the menu planning process: the case of five star hotels in Antalya
Authors: Seyitoglu Faruk 
Published: May 2017

PurposeThe purpose of this paper is to understand how chefs working at five star hotels perceive the menu planning process.Design/methodology/approachCase studies were used to deeply investigate the menu planning process of five star hotels. Data were drawn from in situ interviews and documentation, which were examined via content analysis. After the coding process, themes and categories were extracted and corroborated by direct quotations.FindingsThe findings revealed that the menu planning process can be classified into five major categories. The first category consists of the prerequisites of planning a menu. The second category is “key issues” and encapsulates the managerial, consumer, gastronomic, marketing and external aspects of menu planning. The third category highlights key actors’ responsibilities in the menu planning process, while the fourth category, “trial and improvement,” elaborates on the iterative process of menu design and the key players and issues involved with it. Finally, the last category outlines the difficulties of menu planning.Originality/valueIn the existing academic literature, most research conducted about menu planning only provides conceptual framework while empirical information remains unexamined. However, this qualitative study aims to clarify the components of menu planning in more detail in terms of five star hotel firms that offer various food and beverage operations. The present study is an attempt to fill a gap in the existing literature on the subject.
Occurrence of extended-spectrumβ-lactamase, AmpC and virulence genes inEscherichia coliisolates from vegetable salads in Morocco
Authors: Nayme Kaotar , Barguigua Abouddihaj , Bouchrif Brahim , Diawara Idrissa , El Otmani Fatima , Elmdaghri Naima , Zerouali Khalid , Timinouni Mohammed 
Published: May 2017

PurposeThe purpose of this paper is to assess the occurrence of the extended-spectrumβ-lactamases (ESBLs) and AmpCβ-lactamase genes in 144Escherichia coliisolates recovered from 160 vegetable salad samples.Design/methodology/approachAmong the 144E. coliisolates recovered from 160 vegetable salads, 17 (12 percent) ceftazidime-resistant isolates were screened for ESBL production with the double disk-diffusion test. The ESBL-producing isolates were characterized for antimicrobial resistance, the presence of virulence genes and plasmid-mediated quinolone resistance (PMQR) determinants. The isolates were also subjected to phylogenetic group typing. The existence of plasmid AmpC genes and mutations in the regulatory region of the chromosomal AmpC gene was assessed using polymerase chain reaction (PCR) and sequencing. Allβ-lactamase isolates were further characterized by pulsed-field gel electrophoresis to determine the genetic relatedness.FindingsOverall, 17 (12 percent) of the 144E. coliisolates studied were ceftazidime resistant. Among the 17 isolates, 13 (77 percent) were multidrug resistant and four (23.5 percent) were ESBL producers. The bla CTX-M14 was the only gene detected. Of the 12 AmpC-producing isolates, three (18 percent) harbored plasmid-encoded AmpC and sequencing analysis of the chromosomal AmpC genes revealed mutations in the promoter/attenuator region. PMQR determinants were detected in 9 (52 percent) isolates. A was the most prevalent phylogenetic group (56 percent), followed by groups B1 (31 percent), D (6 percent), and B2 (6 percent). PCR showed that six (50 percent) ESBL/AmpC-producingE. coliisolates carried one and/or two virulence genes. Pulsed-field gel electrophoresis showed no epidemiological relationship between these isolates.Originality/valueThis study places vegetable salads within the spectrum of ecological niches that may be vehicles for antibiotic-resistant bacteria/genes with clinical interest and these findings are worthy of attention as their spread to humans by ingestion cannot be dismissed.
Satisfactions comparisons: women with families, full-time and part-time self-employed
Authors: Ebbers Ilona , Piper Alan 
Published: May 2017

Purpose
In spite of numerous political initiatives, the proportion of self-employed women in Germany has stagnated. This paper aims to offer a new perspective on this problem. The investigation and data gathered about job and life satisfaction of women with families can provide information on the reasons for starting a business, and the low participation of women in entrepreneurial activity.

Design/methodology/approach
After a literature review, representative German panel data is analysed to investigate the job and life satisfaction of full- and part-time self-employed women with a family.

Findings
Self-employed women with families who work full-time are more satisfied with their jobs than those who work part-time. There is no statistically significant difference between these two groups with respect to their life satisfaction.

Research limitations/implications
An implication of the results suggests new ideas and a new focus by policy makers and politicians when trying to increase the quantity of women with families engaging in self-employment. A limitation is that a lack of “within” variation in the data means that the panel nature of the survey cannot be usefully incorporated into the investigation.

Originality/value
Until now, there is limited research about the work and life satisfaction of women with a family comparing full- and part-time self-employment. This analysis is potentially valuable because the number of part-time self-employed women is substantially higher than the number of full-time self-employed women. We find evidence that such women may instead prefer full-time self-employment.
Shared ownership and temporal ownership in Catalan law
Authors: Simón Moreno Héctor , Lambea Llop Núria , Garcia Teruel Rosa Maria 
Published: May 2017

Purpose
The global economic crisis and the housing bubble meltdown have had a significant impact on the Spanish property market. As a result, the homeownership–tenancy dichotomy has become a matter of discussion, and efforts are made to discover formulas that provide affordable, stable and flexible housing access. Taking this background into account, the Catalan lawmaker has implemented the so-called “intermediate tenures” (temporal ownership and shared ownership) into the Catalan Civil Code, which are conceived as a middle ground between ownership and renting. This paper aims to explores how these “intermediate tenures” work.

Design/methodology/approach
These tenures are conceived as a middle ground between ownership and renting and may be used for a variety of purposes. As the Catalan lawmaker has fragmented the right of ownership on the basis of English law, which is a great breakthrough regarding the long-standing conception of the right of ownership in continental legal systems, the paper explores how these “intermediate tenures” work, as regulated in Act 19/2015, in a comparative perspective.

Findings
The paper offers an overview of how these “intermediate tenures” are regulated and which are the problems arising from legislation and the potential uses.

Originality/value
As the temporal ownership confers on the titleholder the domain of an asset for a specifically defined period of time, it does not conform to the right of ownership as it is currently conceived in continental European legal systems, given that it is based on the English leasehold; shared ownership confers on the buyer a property share in the thing, entitling him to the full possession, use and exclusive enjoyment of the thing and to gradually acquire the remaining share. Both are based on the English shared ownership scheme and leasehold, and are legal transplants worth to be analysed.
Applicability of the high performance organization (HPO) framework in the Chinese context
Authors: de Waal André , Wang Amy 
Published: May 2017

PurposeIn recent years, China has shifted its competitive strategy from competing on low cost to producing higher value added products and services, and the country has made the promotion of business excellence a national strategic priority. As a consequence, Chinese organizations need to know the factors that will make them world-class companies. Until recently, not much research has been done into these factors in the Chinese context. The few studies available unfortunately were mainly done only into specific elements of excellence and specific improvement techniques; a holistic and scientifically validated framework for creating high performance organizations (HPOs) cannot be found. The purpose of this study is to evaluate such a framework, which was quite recently developed, for the Chinese context.Design/methodology/approachA possible way forward is to use the HPO framework which was validated in earlier studies for the Asian context. In this paper, this research question is answered: Can the HPO framework be used to help Chinese organization to evaluate and improve the factors for excellence in the Chinese context? The study used a questionnaire which was distributed to respondents of a Chinese state-owned manufacturing enterprise. The results were discussed during a workshop to arrive at the main attention points for the organization.FindingsThe HPO framework was validated for the Chinese context and yielded valuable recommendations for improvement for the case company.Originality/valueThis study fills the gap which currently exists in empirical research about organization performance practices in Chinese. The study also has practical implications as management of Chinese state-owned enterprises, and possibly other Chinese companies, are now able to undertake focused improvement actions.
Managerial strategies to make incentives meaningful and motivating
Authors: Korlén Sara , Essén Anna , Lindgren Peter , Amer-Wahlin Isis , von Thiele Schwarz Ulrica 
Published: May 2017

Purpose
Policy makers are applying market-inspired competition and financial incentives to drive efficiency in healthcare. However, a lack of knowledge exists about the process whereby incentives are filtered through organizations to influence staff motivation, and the key role of managers is often overlooked. The purpose of this paper is to explore the strategies managers use as intermediaries between financial incentives and the individual motivation of staff. The authors use empirical data from a local case in Swedish specialized care.

Design/methodology/approach
The authors conducted an exploratory qualitative case study of a patient-choice reform, including financial incentives, in specialized orthopedics in Sweden. In total, 17 interviews were conducted with professionals in managerial positions, representing six healthcare providers. A hypo-deductive, thematic approach was used to analyze the data.

Findings
The results show that managers applied alignment strategies to make the incentive model motivating for staff. The managers’ strategies are characterized by attempts to align external rewards with professional values based on their contextual and practical knowledge. Managers occasionally overruled the financial logic of the model to safeguard patient needs and expressed an interest in having a closer dialogue with policy makers about improvements.

Originality/value
Externally imposed incentives do not automatically motivate healthcare staff. Managers in healthcare play key roles as intermediaries by aligning external rewards with professional values. Managers’ multiple perspectives on healthcare practices and professional culture can also be utilized to improve policy and as a source of knowledge in partnership with policy makers.