bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in gene expression in vitamin D‐deficiency: Down‐regulation of liver Cyp7a1 and renal Oat3 in mice
Authors: Quach Holly P. , Noh Keumhan , Hoi Stacie Y. , Bruinsma Adrie , Groothuis Geny M.M. , Li Albert P. , Chow Edwin C.Y. , Pang K. Sandy 
Published: December 2017

AbstractThe vitamin D‐deficient model, established in the C57BL/6 mouse after 8 weeks of feeding vitamin D‐deficient diets in the absence or presence of added calcium, was found associated with elevated levels of plasma parathyroid hormone (PTH) and plasma and liver cholesterol, and a reduction in cholesterol 7α‐hydroxylase (Cyp7a1, rate‐limiting enzyme for cholesterol metabolism) and renal Oat3 mRNA/protein expression levels. However, there was no change in plasma calcium and phosphate levels. Appraisal of the liver revealed an up‐regulation of mRNA expressions of the small heterodimer partner (Shp) and attenuation of Cyp7a1, which contributed to hypercholesterolemia in vitamin D‐deficiency. When vitamin D‐sufficient or D‐deficient mice were further rendered hypercholesterolemic with 3 weeks of feeding the respective, high fat/high cholesterol (HF/HC) diets, treatment with 1α,25‐dihydroxyvitamin D3 [1,25(OH)2D3], active vitamin D receptor (VDR) ligand, or vitamin D (cholecalciferol) to HF/HC vitamin D‐deficient mice lowered the cholesterol back to baseline levels. Cholecalciferol treatment partially restored renal Oat3 mRNA/protein expression back to that of vitamin D‐sufficient mice. When the protein expression of protein kinase C (PKC), a known, negative regulator of Oat3, was examined in murine kidney, no difference in PKC expression was observed for any of the diets with/without 1,25(OH)2D3/cholecalciferol treatment, inferring that VDR regulation of renal Oat3 did not involve PKC in mice. As expected, plasma calcium levels were not elevated by cholecalciferol treatment of vitamin D‐deficient mice, while 1,25(OH)2D3 treatment led to hypercalcemia. In conclusion, vitamin D‐deficiency resulted in down‐regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol.
Maximizing Scales Do Not Reliably Predict Maximizing Behavior in Decisions from Experience
Authors: Harman Jason L. , Weinhardt Justin M. , Gonzalez Cleotilde 
Published: December 2017

AbstractIn this paper, we explore the relationships between psychometric and behavioral measures of maximization in decisions from experience (DfE). In two experiments, we measured choice behavior in two experimental paradigms of DfE and self‐reported maximizing tendencies using three prominent scales of maximization. In the repeated consequentialist choice paradigm, participants made repeated choices between two unlabeled options and received consequential feedback on each trial. In the sampling paradigm, participants freely sampled from two options and received feedback on their sampling before making a single consequential choice. Individuals exhibited different degrees of maximizing behavior in both paradigms and across different payoff distributions, but none of the maximizing scales predicted this behavior. These results indicate that maximization scales address constructs that are different from the maximization behavior observed in DfE, and that these measures will need to be improved to reflect behavioral aspects of choice and search from experience. Copyright © 2017 John Wiley & Sons, Ltd.
O4‐Alkylated‐2‐Deoxyuridine Repair by O6‐Alkylguanine DNA Alkyltransferase is Augmented by a C5‐Fluorine Modification
Authors: Sacre Lauralicia , O'Flaherty Derek K. , Archambault Philippe , Copp William , Peslherbe Gilles H. , Muchall Heidi M. , Wilds Christopher J. 
Published: December 2017

AbstractOligonucleotides containing various adducts, including ethyl, benzyl, 4‐hydroxybutyl and 7‐hydroxyheptyl groups, at the O4 atom of 5‐fluoro‐O4‐alkyl‐2′‐deoxyuridine were prepared by solid‐phase synthesis. UV thermal denaturation studies demonstrated that these modifications destabilised the duplex by approximately 10 °C, relative to the control containing 5‐fluoro‐2′‐deoxyuridine. Circular dichroism spectroscopy revealed that these modified duplexes all adopted a B‐form DNA structure. O6‐Alkylguanine DNA alkyltransferase (AGT) from humans (hAGT) was most efficient at repair of the 5‐fluoro‐O4‐benzyl‐2′‐deoxyuridine adduct, whereas the thymidine analogue was refractory to repair. The Escherichia coli AGT variant (OGT) was also efficient at removing O4‐ethyl and benzyl adducts of 5‐fluoro‐2‐deoxyuridine. Computational assessment of N1‐methyl analogues of the O4‐alkylated nucleobases revealed that the C5‐fluorine modification had an influence on reducing the electron density of the O4−Cα bond, relative to thymine (C5‐methyl) and uracil (C5‐hydrogen). These results reveal the positive influence of the C5‐fluorine atom on the repair of larger O4‐alkyl adducts to expand knowledge of the range of substrates able to be repaired by AGT.
Graphitic Carbon Nitride as a Distinct Solid Stabilizer for Emulsion Polymerization
Authors: Cao Qian , Cui Qianling , Yang Yu , Xu Jingsan , Han Chenhui , Li Lidong 
Published: December 2017

Abstractg‐C3N4 has been found to be highly functional in many fields, such as photocatalysis, electrocatalysis, and chemical analysis. Pickering emulsion polymerization is a fascinating strategy to fabricate a range of nanomaterials, in which the emulsion is stabilized by solid particles, rather than molecular surfactants. Herein, we demonstrate that g‐C3N4 can act as a remarkable stabilizer for Pickering emulsion polymerization. Contrary to normal Pickering systems, monodisperse polystyrene microspheres with tunable size, surface charge, and morphology were achieved using this approach. Importantly, the g‐C3N4 hybridized latex is highly processable and has exhibited multiple functions: manufacture of photonic crystals via self‐organization, stabilizing Pickering emulsion owing to proper wettability, and acting as bioimaging agents with enriched fluorescent colors. Considering the easy synthesis and low cost of g‐C3N4, our approach has a high potential for scale‐up synthesis and practical translation.
Atrial fibrillation and risk of cardiovascular events and mortality in patients with symptomatic peripheral artery disease: A meta‐analysis of prospective studies
Authors: Vrsalović Mislav , Presečki Ana Vrsalović 
Published: December 2017

BackgroundAtrial fibrillation (AF) is associated with adverse outcomes in terms of survival and morbidity. Peripheral artery disease (PAD) and AF share several common risk factors and often coexist. Whether AF has a prognostic role in patients with PAD has not been extensively studied.HypothesisAF is associated with major adverse cardiac events (MACE) and mortality in symptomatic PAD patients.MethodsUsing MEDLINE and Scopus, we searched for studies published before December 2016 that evaluated cardiovascular outcomes based on the presence/absence of AF in a prospective manner with a follow‐up period of ≥12 months. The outcomes were reported using a random‐effects model, and heterogeneity was assessed using the I2 statistic. Sensitivity analyses were performed to test the contribution of each study to the overall results.ResultsSix prospective studies (Newcastle‐Ottawa score range, 7–9) with 14 656 patients were included in the final analysis (age range, 66–70 years; median follow‐up, 1.4 years). Our pooled analysis found a significant association between AF and mortality (odds ratio: 2.52, 95% confidence interval: 1.91‐3.34, I2 = 32.6%), without evidence of publication bias (P = 0.63). Meta‐analysis showed a significant impact of AF on MACE (odds ratio: 2.54, 95% confidence interval: 1.78‐3.63, I2 = 74.3%), without detected publication bias (P = 0.08).ConclusionsAF is associated with increased risk of mortality and MACE in symptomatic PAD.
Impact of coronary artery disease in patients undergoing transcatheter aortic valve replacement: Insights from the FRANCE‐2 registry
Authors: Puymirat Etienne , Didier Romain , Eltchaninoff Hélène , Lung Bernard , Collet Jean‐Philippe , Himbert Dominique , Durand Eric , Leguerrier Alain , Leprince Pascal , Fajadet Jean , Teiger Emmanuel , Chevreul Karine , Lièvre Michel , Tchetché Didier , Leclercq Florence , Chassaing Stéphan , Le Breton Hervé , Donzeau‐Gouge Patrick , Lefèvre Thierry , Carrié Didier , Gillard Martine , Blanchard Didier 
Published: December 2017

BackgroundCoronary artery disease (CAD) is common in patients undergoing transcatheter aortic valve replacement (TAVR). However, the impact of CAD distribution before TAVR on short‐ and long‐term prognosis remains unclear.HypothesisWe hypothesized that the long‐term clinical impact differs according to CAD distribution in patients undergoing TAVR using the FRench Aortic National CoreValve and Edwards (FRANCE‐2) registry.MethodsFRANCE‐2 is a national French registry including all consecutive TAVR performed between 2010 and 2012 in 34 centers. Three‐year mortality was assessed in relation to CAD status. CAD was defined as at least 1 coronary stenosis >50%.ResultsA total of 4201 patients were enrolled in the registry. For the present analysis, we excluded patients with a history of coronary artery bypass. CAD was reported in 1252 patients (30%). Half of the patients presented with coronary multivessel disease. CAD extent was associated with an increase in cardiovascular risk profile and in logistic EuroSCORE (European System for Cardiac Operative Risk Evaluation) (from 19.3% ± 12.8% to 21.9% ± 13.5%, P < 0.001). Mortality at 30 days and 3 years was 9% and 44%, respectively, in the overall population. In multivariate analyses, neither the presence nor the extent of CAD was associated with mortality at 3 years (presence of CAD, hazard ratio [HR]: 0.90; 95% confidence interval [CI]: 0.78‐1.07). A significant lesion of the left anterior descending (LAD) was associated with higher 3‐year mortality (HR: 1.42; 95% CI: 1.10‐1.87).ConclusionsCAD is not associated with decreased short‐ and long‐term survival in patients undergoing TAVR. The potential deleterious effect of LAD disease on long‐term survival and the need for revascularization before or at the time of TAVR should be validated in a randomized control trial.
Real‐world incidence of efficacy and safety outcomes in patients on direct oral anticoagulants with left ventricular systolic dysfunction at a tertiary referral center
Authors: Tseng Andrew S. , William Schleifer J. , Shen Win‐Kuang , McBane Robert , Mankad Sunil , Esser Heidi , Vucicevic Darko , Shamoun Fadi E. 
Published: December 2017

BackgroundPatients with heart failure (HF) have increased risk for thromboembolic events. Real‐world incidences of efficacy and safety outcomes of direct oral anticoagulants (DOACs) in patients with left ventricular systolic dysfunction (LVSD) are of growing clinical interest.HypothesisReal‐world efficacy and safety outcomes of DOACs in patients with LVSD will be similar to those of LVSD or HF subgroups in the RE‐LY, ROCKET‐AF, and ARISTOTLE trials.MethodsWe performed a retrospective review of adult patients with LVSD (left ventricular ejection fraction ≤40%) on DOAC therapy between 2010 and 2016. Incidences of safety and efficacy outcomes of anticoagulation with DOACs were extracted from primary and secondary hospital discharge diagnoses.ResultsDOACs were prescribed to 287 patients with LVSD over a mean follow‐up of 313.3 ± 52.3 days. Many patients had moderate and severe chronic kidney disease (28.9% and 10.1%, respectively) and indications for anticoagulation therapy other than atrial fibrillation (19.9%). For efficacy outcomes, the calculated incidence rates of ischemic stroke and systemic embolism were 1.2 (95% confidence interval [CI]: 0.25‐3.56) and 0.81 (95% CI: 0.10‐2.94) events per 100 person‐years, respectively. For the safety outcomes, incidence rates of GI bleeding and intracranial hemorrhage were 2.4 (95% CI: 0.8‐5.3) and 0.41 (95% CI: 0.1‐2.2) events per 100 patient‐years, respectively.ConclusionsOur findings are largely compatible with the results of LVSD or HF subgroups in RE‐LY, ROCKET‐AF, and ARISTOTLE trials and add to increasing confidence that DOACs can be safely used for stroke and systemic embolism prevention in patients with LVSD.
How to Enhance Green Service and Green Product Innovation Performance? The Roles of Inward and Outward Capabilities
Authors: Chang Ching‐Hsun 
Published: December 2017

AbstractThe findings highlight the differences between inward and outward capabilities in Taiwanese service and manufacturing industries. The purpose of this study is to develop an original framework to explore the effects of both outward and inward capabilities on competitive advantage with green service or green product innovation performance as a mediator. In this study, environmental scanning is considered the outward capability and the locus of planning is considered the inward capability. In total, 202 and 161 valid questionnaires were returned from service and manufacturing companies, respectively. In the service industry, if companies would like to increase their green service innovation performance, they should enhance both environmental scanning capability and locus of planning. But in manufacturing industry, if companies would like to increase their green product innovation performance, they should only enhance environmental scanning capability. By addressing the constructs, this study presents a novel perspective on green innovation. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Pharmacological interaction of α‐bisabolol and diclofenac on nociception, inflammation, and gastric integrity in rats
Authors: Ortiz Mario I. , Cariño‐Cortés Raquel , Ponce‐Monter Héctor A. , Castañeda‐Hernández Gilberto , Chávez‐Piña Aracely Evangelina 
Published: December 2017

Abstract

Preclinical Research & Development

The combination of nonsteroidal anti‐inflammatory drugs (NSAIDs) with herbal products having analgesic and anti‐inflammatory effects may increase their beneficial effects and limit their side effects. In this study, the effects of an interaction between α‐bisabolol and the NSAID, diclofenac on nociception (formalin test), inflammation (paw inflammation produced by carrageenan) and gastric injury in rat was assessed. Diclofenac, α‐bisabolol, or diclofenac–α‐bisabolol combinations produced antinociceptive and anti‐inflammatory effects in rat (p < .05). The systemic administration of diclofenac, but not α‐bisabolol, produced gastric damage while the diclofenac–α‐bisabolol combinations produced limited gastric damage. Effective dose (ED40) values were determined for each individual drug and analyzed isobolographically. The theoretical ED40 values for the antinociceptive (98.89 mg/kg) and the anti‐inflammatory (41.2 mg/kg) effects differed from the experimental ED40 values (antinociception: 38.7 mg/kg and anti‐inflammation: 13.4 mg/kg). We concluded that the interactions between diclofenac and α‐bisabolol are synergistic. These data suggest that the diclofenac–α‐bisabolol combinations can interact to produce minor gastric damage, thereby offering a safer therapeutic alternative for the clinical management of inflammation and/or inflammatory pain.
ConR: An R package to assist large‐scale multispecies preliminary conservation assessments using distribution data
Authors: Dauby Gilles , Stévart Tariq , Droissart Vincent , Cosiaux Ariane , Deblauwe Vincent , Simo‐Droissart Murielle , Sosef Marc S. M. , Lowry Porter P. , Schatz George E. , Gereau Roy E. , Couvreur Thomas L. P. 
Published: December 2017

AbstractThe Red List Categories and the accompanying five criteria developed by the International Union for Conservation of Nature (IUCN) provide an authoritative and comprehensive methodology to assess the conservation status of organisms. Red List criterion B, which principally uses distribution data, is the most widely used to assess conservation status, particularly of plant species. No software package has previously been available to perform large‐scale multispecies calculations of the three main criterion B parameters [extent of occurrence (EOO), area of occupancy (AOO) and an estimate of the number of locations] and provide preliminary conservation assessments using an automated batch process. We developed ConR, a dedicated R package, as a rapid and efficient tool to conduct large numbers of preliminary assessments, thereby facilitating complete Red List assessment. ConR (1) calculates key geographic range parameters (AOO and EOO) and estimates the number of locations sensu IUCN needed for an assessment under criterion B; (2) uses this information in a batch process to generate preliminary assessments of multiple species; (3) summarize the parameters and preliminary assessments in a spreadsheet; and (4) provides a visualization of the results by generating maps suitable for the submission of full assessments to the IUCN Red List. ConR can be used for any living organism for which reliable georeferenced distribution data are available. As distributional data for taxa become increasingly available via large open access datasets, ConR provides a novel, timely tool to guide and accelerate the work of the conservation and taxonomic communities by enabling practitioners to conduct preliminary assessments simultaneously for hundreds or even thousands of species in an efficient and time‐saving way.
Are there morphological and life‐history traits under climate‐dependent differential selection in S TunesianDiplotaxis harra(Forssk.) Boiss. (Brassicaceae) populations?
Authors: Oberprieler Christoph , Zimmer Claudia , Bog Manuela 
Published: December 2017

AbstractAdaptation of morphological, physiological, or life‐history traits of a plant species to heterogeneous habitats through the process of natural selection is a paramount process in evolutionary biology. We have used a population genomic approach to disentangle selection‐based and demography‐based variation in morphological and life‐history traits in the cruciferDiplotaxis harra(Forssk.) Boiss. (Brassicaceae) encountered in populations along aridity gradients in S Tunisia. We have genotyped 182 individuals from 12 populations of the species ranging from coastal to semidesert habitats using amplified fragment length polymorphism (AFLP) fingerprinting and assessed a range of morphological and life‐history traits from their progeny cultivated under common‐garden conditions. Application of three different statistical approaches for searchingAFLPloci under selection allowed us to characterize candidate loci, for which their association with the traits assessed was tested for statistical significance and correlation with climate data. As a key result of this study, we find that only the shape of cauline leaves seems to be under differential selection along the aridity gradient in S Tunisian populations ofDiplotaxis harra,while for all other traits studied neutral biogeographical and/or random factors could not be excluded as explanation for the variation observed. The counter‐intuitive finding that plants from populations with more arid habitats produce broader leaves under optimal conditions of cultivation than those from more mesic habitats is interpreted as being ascribable to selection for a higher plasticity in this trait under more unpredictable semidesert conditions compared to the more predictable ones in coastal habitats.
Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem‐loop structure in its 3′UTR
Authors: Hanieh Hamza , Masuda Kazuya , Metwally Hozaifa , Chalise Jaya P. , Mohamed Maged , Nyati Kishan K. , Standley Daron M. , Li Songling , Higa Mitsuru , Zaman Mohammad M. , Kishimoto Tadamitsu 
Published: December 2017

AbstractAT‐rich interactive domain‐containing protein 5a (Arid5a) is an RNA‐binding protein (RBP) required for autoimmunity via stabilization of interleukin‐6 (Il6) and signal transducer and activator of transcription 3 (STAT3) mRNAs. However, the roles of Arid5a in Th17 cells and its association with autoimmunity remain unknown. Here, we show that the levels of Arid5a and OX40 are correlated in CD4+ T cells under Th17 conditions in an IL‐6‐dependent manner. Lack of Arid5a in T cells reduced OX40 expression levels and repressed IL‐17 production in response to OX40 ligation. Arid5a stabilized OX40 mRNA by recognizing the alternative decay element (ADE)‐like stem‐loop (SL) in the 3′ untranslated region (3′UTR). Interestingly, Arid5a impaired the RNA‐destabilizing functions of Regnase‐1 and Roquin‐1 on OX40 ADE‐like SL. In EAE, Arid5a‐deficient mice exhibited resistance to EAE, with reduced OX40 expression in CD4+ T cells, and the number of CD4+CD45+ T cells was decreased in CNS. Furthermore, ameliorated EAE was induced by adoptive transfer of Arid5a−/− encephalitogenic CD4+ T cells expressing less OX40 mRNA and producing less IL‐17. In conclusion, our findings indicate that the Arid5a/OX40 axis in CD4+ T cells may have important implications in pathogenesis of autoimmune diseases such as EAE.
How well can we simulate complex hydro‐geomorphic process chains? The 2012 multi‐lake outburst flood in the Santa Cruz Valley (Cordillera Blanca, Perú)
Authors: Mergili Martin , Emmer Adam , Juřicová Anna , Cochachin Alejo , Fischer Jan‐Thomas , Huggel Christian , Pudasaini Shiva P. 
Published: December 2017

AbstractChanging high‐mountain environments are characterized by destabilizing ice, rock or debris slopes connected to evolving glacial lakes. Such configurations may lead to potentially devastating sequences of mass movements (process chains or cascades). Computer simulations are supposed to assist in anticipating the possible consequences of such phenomena in order to reduce the losses. The present study explores the potential of the novel computational tool r.avaflow for simulating complex process chains. r.avaflow employs an enhanced version of the Pudasaini () general two‐phase mass flow model, allowing consideration of the interactions between solid and fluid components of the flow. We back‐calculate an event that occurred in 2012 when a landslide from a moraine slope triggered a multi‐lake outburst flood in the Artizón and Santa Cruz valleys, Cordillera Blanca, Peru, involving four lakes and a substantial amount of entrained debris along the path. The documented and reconstructed flow patterns are reproduced in a largely satisfactory way in the sense of empirical adequacy. However, small variations in the uncertain parameters can fundamentally influence the behaviour of the process chain through threshold effects and positive feedbacks. Forward simulations of possible future cascading events will rely on more comprehensive case and parameter studies, but particularly on the development of appropriate strategies for decision‐making based on uncertain simulation results. © 2017 The Authors. Earth Surface Processes and Landforms published by John Wiley & Sons Ltd.
Oropharynx‐directed ipsilateral irradiation for p16‐positive squamous cell carcinoma involving the cervical lymph nodes of unknown primary origin
Authors: Chen Allen M. , Meshman Jessica , Hsu Sophia , Yoshizaki Taeko , Abemayor Elliot , John Maie St. 
Published: December 2017

AbstractBackgroundThe purpose of this study was to present our findings on the use of limited‐field, oropharynx‐directed ipsilateral irradiation for p16‐positive squamous cell carcinoma of unknown primary origin.MethodsBetween April 2011 and January 2016, 25 patients with a histological diagnosis of p16‐positive squamous cell carcinoma were selectively irradiated to the ipsilateral oropharynx and cervical neck for tumors of unknown primary origin. The dose to the oropharynx ranged from 54‐60 Gy (median 60 Gy) in 30‐33 fractions. Concurrent cisplatin‐based chemotherapy was administered to 8 patients (32%).ResultsThe actuarial 2‐year estimates of locoregional control, progression‐free survival, and overall survival were 91%, 87%, and 92%, respectively. One patient failed in the contralateral neck. There was no grade 3 + toxicity in either the acute or late setting.ConclusionOropharynx‐directed, ipsilateral radiation results in disease control that compares favorably with historical controls treated by comprehensive mucosal and bilateral neck radiation.