bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary habits and all-cause mortality risk in the adult population. Results of a 6-year prospective follow-up of the ESSE-RF study cohort
Authors: Karamnova N. S. , Kapustina A. V. , Kutsenko V. A. , Shvabskaia O. B. , Balanova Yu. A. , Evstifeeva S. E. , Imaeva A. E. , Kotova M. B. , Maksimov S. A. , Muromtseva G. A. , Kulakova N. V. , Kalachikova O. N. , Chernykh T. M. , Belova O. A. , Artamonova G. V. , Grinshtein Yu. I. , Libis R. A. , Rotar O. P. , Trubacheva I. A. , Efanov A. Yu. , Shalnova S. A. , Drapkina O. M. 
Published: October 2024

Dietary habits affect the risk of all-cause mortality (ACM) in the adult population according to prospective studies.Aim. To assess the effect of dietary habits on the ACM risk in the Rus­sian population.Material and methods. The prospective cohort included represen­ta­tive samples of 10 Russian regions (n=17175, 6767 men and 10408 wo­men aged 25-64 years), examined in 2012-2014 as part of the ESSE-RF study. Dietary habits were studied based on the consumption rate of the main food groups. The vital status of the cohort was updated every 2 years. The follow-up period was 6 years. Kaplan-Meier curves were used to analyze overall survival (OS). Cox proportional hazards model was used to assess the ACM risk.Results. In the Russian population, an increase in OS is associated with daily consumption of vegetables/fruits, dairy products (milk, kefir, yogurt, cottage cheese, and cheese), and the presence of the Heal­thy Eating Model (HEM) in the diet. A decrease in OS is associated with excess salt intake (ESI) in the diet, the habit of adding salt to pre­pared foods, and daily consumption of pickles (p<0,05). Among men, an increase in OS is observed with daily consumption of fruits/ve­ge­tables, cheese, and HEM, while a decrease is observed with daily consumption of pickles, general ESI, and the habit of adding salt to foods (p<0,05). In women, daily consumption of red meat, liquid dairy products, cheese, and sweets is associated with an increase in OS (p<0,05). The risk of ACM in the general population and among men increases with ESI — relative risk (RR)=1,31 [1,06-1,61] (p=0,012) and 1,41 [1,06-1,87] (p=0,017), respectively, adding salt to food — RR=1,34 [1,09-1,65] (p=0,006) and 1,5 [1,13-1,98] (p=0,005) and daily consumption of pickles — RR=1,48 [1,02-2,14] (p=0,039) and 1,5 [1,01-2,54] (p=0,045). In women, regular consumption of red meat — RR=0,7 [0,49-0,99] (p=0,043), liquid dairy products — RR=0,68 [0,5-0,93] (p=0,015) and cheese — RR=0,64 [0,46-0,9] (p=0,011) were associated with an ACM decrease.Conclusion. An ACM risk increase in the general population and among men is associated with excess salt intake, and a decrease in ACM risk in women is associated with the regular inclusion of red meat and dairy products in the diet.
Riesgo de depresión posparto en una institución de salud de Medellín
Authors: Salazar Sepúlveda Daniela , Usma Trujillo Manuela , Tobón Otálvaro Laura Cristina , Aristizabal Gómez Isabela , García Henao Valentina , Calderón Álvarez Luisa Fernanda , Giraldo Montoya Dora Isabel 
Published: October 2024

Introducción: la depresión posparto es la complicación psiquiátrica más frecuente del periodo posnatal y con altas repercusiones en el bienestar de la madre y del bebé. Objetivo: identificar el riesgo de depresión posparto en una institución de salud de Medellín en el periodo del año 2021-2. Metodología: estudio cuantitativo de tipo descriptivo transversal no probabilístico por conveniencia. La población correspondió a todas las madres accesibles que firmaron el consentimiento informado y cumplieron los criterios de inclusión: encontrarse en posparto inmediato o mediato (hasta 40 días), mayores de 18 años y alfabetas. Se empleó una encuesta elaborada por las investigadoras para obtener los datos sociodemográficos y obstétricos. Para determinar el riesgo de depresión posparto, se empleó la Escala de Edimburgo para depresión posparto, autoaplicada y de uso libre. El análisis estadístico descriptivo se realizó mediante frecuencias absolutas y relativas y el riesgo de depresión posparto fue interpretado mediante el puntaje global, acorde a la explicación de la escala. Se utilizó el programa estadístico Epi-info v. 7.2.5.0. El estudio contó con la aprobación del Comité de Ética de la Escuela de Ciencias de la Salud y por el Comité de Investigación de la Institución de salud de Medellín. Resultados: la mediana de edad fue 25 años, el 50 % de las participantes tenía un hijo y el 64 % se encontraba en unión libre, un 46 % tenía escolaridad secundaria, el 42 % era ama de casa, el 48 % se ubicaba en el estrato socioeconómico 2 y el 70 % afirmó que su embarazo fue deseado. Al analizar el puntaje global de la Escala de Edimburgo se encontró que el 70 % de las madres no presentaron riesgo de depresión posparto. El 30 % del total de la muestra registró algún riesgo de depresión posparto. Conclusiones: Un 13% de las madres presentaron algún riesgo de depresión posparto y el 17% de las madres obtuvieron un riesgo alto de posible depresión posparto.
Enhancing wine authentication: leveraging 12,000+ international mineral wine profiles and artificial intelligence for accurate origin and variety prediction
Authors: Sarlo Leticia , Duroux Coraline , Clément Yohann , Lanteri Pierre , Rossetti Fabien , David Olivier , Tillement Augustin , Gillet Philippe , Hagège Agnès , David Laurent , Dumoulin Michel , Marchal Richard , Tillement Théodore , Lux François , Tillement Olivier 
Published: October 2024

For the wine industry, ensuring quality and authenticity hinges on the precise determination of wine origin. In our study, we developed a fast semi-quantitative method to analyse 41 chemical elements in wine, employing inductively coupled plasma mass spectrometry (ICP-MS). This methodology characterises what we term the mineral wine profile (MWP). In contrast to an organic molecular profile, the mineral composition of a wine remains constant from the moment it is bottled. Mineral elements play a crucial role in the terroir of wine: they pass primarily from soil to grape and are then influenced by various vinification techniques. Indeed, it is widely recognised that the original soil characteristics are altered by a multitude of winemaking procedures, presenting a considerable challenge when endeavouring to extract origin-related information in a typical scenario. Our study demonstrates that statistical analyses and artificial intelligence (AI) could be a tool for accurately deciphering origin information within the MWP, provided sufficient mineral elements are measured and a comprehensive database of wine samples is employed to establish effective learning. In this study, a dataset comprising 12,966 MWPs was created in just over a year. The first analysis revealed correlations between the elements in wine, especially between rare earth elements, between macronutrients and between micronutrients. A machine learning method was then developed to assess wine origin and principal grape variety. Six models were tested by comparing the area under the receiver operating characteristic curve (AUC), with eXtreme Gradient Boosting as the chosen model. Mean accuracies of 92 % for country classification, 91 % for the French wine region, and 85 % for the main grape variety were obtained, and mean AUC scores of 0.964 for country classification, 0.961 for the French wine region and 0.914 for the main grape variety. This study represents the first comprehensive investigation at this scale on wine samples, and underscores the importance of using a comprehensive MWP dataset for AI applications when verifying wine origin. The authentication of a wine with over 99 % specificity could be routinely achievable through this approach.
The role of teachers in developing multicultural education of religious tolerance in primary schools: literature study
Authors: Fauziah Nursifa , Zakiah Linda , Jannah Hasbiya Miftahul , Elifas Leonardo , Safitri Nurrohmah 
Published: October 2024

This study aims to examine the role of teachers in developing tolerance among students. Tolerance is the ability to appreciate differences and resolve conflicts peacefully. Teachers have a very important role in shaping this attitude of tolerance through an inclusive learning approach, fostering universal values, and providing examples of tolerance behavior in everyday life. This research is a qualitative research with literature study. The subject and instrument of this research is the researcher himself by searching for relevant sources. Data were collected through content analysis which involved several steps, such as determining the problem, developing a framework, developing methodological tools, data analysis, and data interpretation.Â The research findings show that teachers who practice multicultural education-oriented learning approaches and integrate subject matter with tolerance values are able to have a significant impact in shaping students' tolerance attitudes. This multicultural education aims to appreciate and understand diversity in society.
TOO-BERT: A Trajectory Order Objective BERT for self-supervised representation learning of temporal healthcare data
Authors: Amirahmadi Ali , Etminani Farzaneh , Bjork Jonas , Melander Olle , Ohlsson Mattias 
Published: October 2024

Abstract

The growing availability of Electronic Health Records (EHRs) presents an opportunity to enhance patient care by uncovering hidden health risks and improving informed decisions through advanced deep learning methods. However, modeling EHR sequential data, denoted patient trajectories, is complex due to the evolving relationships between diagnoses and treatments over time, where medical conditions and interventions alter the likelihood of future health outcomes over time. While BERT-inspired models have shown promise in modeling EHR sequences by pretraining on the masked language modeling (MLM) objective, they struggle to fully capture the intricate, temporal dynamics of disease progression and medical interventions.

In this study, we introduce TOO-BERT, a novel adaptation that enhances MLM-pretrained transformers by explicitly incorporating temporal information from patient trajectories. TOO-BERT encourages the model to learn complex causal relationships between diagnoses and treatments using a new self-supervised learning task, the Temporal Order Objective (TOO). This is achieved through two proposed methods: Conditional Code Swapping (CCS) and Conditional Visit Swapping (CVS).

We evaluate TOO-BERT on two datasets, MIMIC-IV hospitalization records and the Malmö Diet cohort—comprising approximately 10 and 8 million medical codes, respectively. TOO-BERT demonstrates superior performance in predicting Heart Failure (HF), Alzheimer's Disease (AD), and Prolonged Length of Stay (PLS) compared to standard MLM-pretrained transformers, and notably excels in HF prediction even with limited fine-tuning data.

Our results underscore the effectiveness of integrating temporal ordering objectives into MLM-pretrained models, enabling deeper insights into the complex relationships in EHR data. Attention analysis further reveals TOO-BERT’s ability to capture and represent sophisticated structural patterns within patient trajectories.
Size matters: A new view of the relationship between shape and size for molten volcanic ballistics.
Authors: Sork Amilea Rae , Kennedy Ben M , Watson Leighton , Taddeucci Jacopo , Fitzgerald Rebecca , Sellier Mathieu , Biensan Clothilde , Andronico Daniele , Scarlato Piergiorgio , Bello Elisabetta Del , Ricci Tullio 
Published: October 2024

Abstract

Volcanic ballistic projectiles (VBPs) are a common hazard near volcanic vents and often threaten volcano tourists, especially at accessible volcanoes with Strombolian eruption style. Current ballistic hazard models used to estimate potential VBP impact zones often assume round and solid (fixed shape) projectiles, though the validity of these assumptions remains uncertain. In this study, we use high-speed video observations to examine the shape and size distribution of molten VBPs, termed “bombs”, from Strombolian eruptions at Stromboli (in 2014 and 2017) and Etna (in 2014) volcanoes (Italy). We provide a framework for describing in-flight bomb shapes, defining three shape classes (rounded, elongate, and bilobate) and subclass end members. The ratio of rounded to total VBPs decreases with size; most bombs (71% of the total catalogued) are smaller than 0.16 m and tend to be rounded (53% at all sizes and 62% for < 0.16 m); however, 80% of the bombs larger than 0.32 m tend to be elongate or bilobate. This trend is generally consistent across Strombolian eruptions in both this study and previous studies. However, video datasets of bomb-bearing eruptions at Batu Tara (Indonesia, 2014, Strombolian to Vulcanian) and Cumbre Vieja (Canary Islands, 2021, strong Strombolian and high fire-fountaining) show fewer elongate and bilobate bombs, especially at larger sizes. This size-shape relationship presented here has not been previously accounted for in ballistic models but has the potential to provide a size-based drag coefficient within ballistic models, leading to more accurate modelling results.
Radial Support Force: A Key Player in Vena Cava Neointimal Hyperplasia
Authors: Jiang Rui , Guo Kang , Gong Maofeng , He Xu , Gu Jianping 
Published: October 2024

Abstract

Objective
Neointimal hyperplasia (NIH) is a risk factor for inferior vena cava filter (I VCF) retrieval failures and damage to the inferior vena cava (IVC) wall post-retrieval. Unfortunately, the mechanical properties of IVCFs have not been evaluated and are not readily available from the manufacturer. This study aimed to investigate the correlations between radial support force (RSF) and NIH, and the release of tumor necrosis factor-alpha (TNF-α) during this process.
Materials and Methods
RSFs exerted by filter struts at various IVC diameters were analyzed with five replicates in vitro. In vivo, Bama miniature swine were randomly fitted with IVCFs of 32 mm or 20 mm diameter. After a dwelling time of three weeks, the thickness of NI H and TNF-α percentage (%) in the areas adjacent to IVCF struts were determined on hematoxylin and eosin. Correlations were assessed using student’s t-test, chi-square test, and linear regression analyses.
Results
Following IVCF placement, IVC morphology changed from oval to circular. A mismatch between IVC and filter diameter generated an oversizing ratio (OR), with a mean OR of 113.06 ± 48.91% (range, 61. 73-166.52%). RSFs of 4.56 ± 0.97 N (range, 3.54–5.61 N) showed a linear dose-response relationship with ORs (R² = 0.718, p < .001). Macroscopic presentation of IVCs in the 3rd week showed significant vessel response in the caval wall, characterized by vessel wall proliferation. NIH thickness increased with the enlarged RSFs, and linear regression analyses demonstrated a U-shaped dose-response relationship (R2 = .630, p < .001). A larger TNF-α content at minimal caval diameter was observed with increased RSFs, indicating a more severe presence of TNF-α following the increased RSF (R2 = .777, p < .001).
Conclusion
Differences in RSFs are consistent with ORs; RSFs increased with the larger ORs of IVCF and IVC diameter. Increased RSFs correlate linearly with greater NIH thickness. Evaluation of IVCF yielded a significantly higher RSF at a smaller caval diameter, with higher levels of TNF-α during expansion, supporting a linear association with greater NIH.
Scalable and Sustainable Reductive Amidation of Nitroarenes, Nitroalkenes, and Nitroalkyls with Acyl Saccharins in Aqueous Media
Authors: Re D Srinivasa , Khamkar Sunil L , Mohan Rayala , J Santhosh , Shinde Harish M. , Handore Kishor L , Mohan S Venkata 
Published: October 2024

Abstract

We present a scalable and sustainable methodology for synthesizing N-substituted amides directly from readily available nitroarenes, nitroalkenes, nitroalkyls, and acyl saccharin in aqueous media. This eco-friendly and atom-efficient approach, which avoids column chromatography, demonstrates excellent functional group compatibility and high yield for key amide structures. The method's applicability extends to the formal synthesis of Disyprin, a bromopyrrole alkaloid, as well as amide-based pharmaceuticals and agrochemicals. Additionally, we demonstrate its effectiveness in the multigram-scale synthesis of paracetamol, alongside saccharin and solvent recycling. A comprehensive Life Cycle Assessment (LCA; ISO 14044) was conducted to evaluate the environmental impacts and sustainability of nine selected Active Pharmaceutical Ingredients (APIs) produced via Non-Amidation Route (NAR) and Amidation Route (AR). The study reveals that saccharin-acetylation methods significantly reduce carbon footprints and environmental impacts compared to NAR methods which is notably carbon-negative and resource-efficient. Further impact reduction is achievable through saccharin recycling and the adoption of low-carbon and renewable energy sources, highlighting the potential of saccharin-based processes to substantially mitigate environmental burdens in pharmaceutical synthesis.
Visual real-time monitor ejaculatory-orgasm using transrectal ultrasound to identify the cause of Aspermia
Authors: Wenlong Xie , Wenrong Liu , Zhenfan Zhao , Hui Jiang , Tao Jiang , Letian Wei , Lei Zheng , Xiucheng Zhang 
Published: October 2024

Abstract

Objective
Aspermia is a common ejaculatory disorder having a feeling of orgasm,but no semen after masturbation or sex orgasm. Complete retrograde ejaculation is the common cause of aspermia The diagnosis of complete retrograde ejaculation is mainly determined by the presence of sperm after ejaculation in urine and no seminal fluid emerges from the penis at orgasm, we found it is not true by a visually real-time monitor ejaculatory-orgasm using transrectal ultrasound, this technique help us to exactly identify the cause of Aspermia and insights into the underlying mechanisms for Aspermia.
Methods
In a total of 11 cases of aspermia, with a large number sperms in the post-ejaculation urine, we have diagnosed these patients as retrograde ejaculation. we used transrectal real-time dynamic ultrasound to scrutinize the ejaculatory-orgasm process. To trigger ejaculation, audiovisual sexual stimulation was administered manually. During this procedure, we attentively observed and documented the alterations in the seminal vesicle, the neck of the bladder, the prostatic urethra, as well as the dynamic flow of semen, aiming for a comprehensive understanding of the ejaculatory-orgasm .
Results
Among the 11 cases, a mere 8 succeeded in completing the transrectal real-time dynamic monitoring of ejaculatory-orgasm. Of these, 6 cases exhibited distinctive signs of seminal vesicle contraction, posterior urethra dilation, bladder neck disclosure, and semen reversely flow into the bladder. The cause of these cases was retrograde ejaculation. In contrast, the remaining 2 cases displayed neither seminal vesicle contraction nor significant changes in the bladder neck, and no semen was found to flow backwards into the bladder. This suggested that the cause of these two cases was not retrograde ejaculation, but rather an emission disorder. According to our new technique we found that 2 cases diagnosis by the well-established diagnostic criteria,(the confirmation of retrograde ejaculation relies heavily on the presence of cloudy post-ejaculatory urine, and an abundant count of sperms in cases of aspermia) was misdiagnosis ,the aforesaid diagnostic criteria is not infallible, with an estimated misdiagnosis rate of approximately 25% in our cases.
Conclusion
Real-time dynamic transrectal ultrasound monitoring ejaculatory-orgasm is a novel and visually intuitive technique to explore potential cause behind ejaculation disorder .It provides valuable insights into the underlying mechanisms for aspermia .Moreover, We approved that not all cases of aspermia accompanied by a significant amount of sperm in post-ejaculation urine are attributed to complete retrograde ejaculation by this technique.
MyD88 mediates noncytopathic bovine viral diarrhea virus replication by regulating cellular autophagy and proliferation
Authors: Li Xiaobing , Wang Kui , Hu Yuan , Jing Yang , jie Xu , Chen Yajing , Liu Songhao , Jiang Kangfeng 
Published: October 2024

Abstract

Bovine viral diarrhea virus(BVDV) is classified into cytopathic (CP) and noncytopathic (NCP) types. Previous studies have confirmed that NCP BVDV infection is the main cause of persistent infection and immune suppression in cattle, and the molecular mechanism of its immune evasion remains unclear. We initially examined the replication of the AV303 strain (NCP BVDV) in MDBK cells at different time points. Proteomic analysis at the peak replication time point revealed that the TLR signaling pathway and the adaptor protein MyD88 were upregulated. We subsequently confirmed that AV303 induced autophagy and proliferation in cells, as indicated by increased autophagic activity and cell proliferation rates following viral infection. Knocking down MyD88 downregulated the virus-induced activation of autophagy and proliferation. Mechanistically, AV303 regulates cell proliferation by promoting ERK1/2 and mTOR, and ERK1/2 activity is inhibited after MyD88 is knocked down. AV303 replication levels increased with autophagy activation and decreased with autophagy inhibition. This study demonstrates that the activity of MyD88 mediated by the AV303 strain can regulate host cell autophagy and proliferation, creating advantageous conditions for its replication. This study demonstrates a new mechanism host-NCP BVDV interaction and the potential of MyD88 as a novel anti-NCP BVDV drug.
Case Report: A rare case of hereditary colorectal cancer with brain tumour with café au lait spots in a male child: Constitutional Mismatch Repair Deficiency (CMMRD) Syndrome.
Authors: Khurshid Zubair , shaikh Mishraz , Talat Tarek 
Published: October 2024

Abstract

Background: Colorectal Carcinoma is a rarely seen in Paediatric population. Hereditary colorectal cancers due to Mismatch Repair Deficiency results in colorectal and brain tumours in early childhood.
Case presentation: We present an 11-year-old boy who presented with Colorectal cancer and brain tumour due to Congenital Mismatch Repair Deficiency Syndrome with a family history of sibling deaths due to brain tumours.
Conclusions: Hereditary Colorectal Cancers due to Mismatch Repair gene mutations causes early colorectal Cancers in children and members of such families should be genetically screened for any mutations.