bluuebunny/crossref_metadata_2025_split huggingface dataset:
Onychomycosis in patients with nail psoriasis: a point to point discussion
Authors: Rigopoulos Dimitrios , Papanagiotou Vasilios , Daniel Ralph , Piraccini Bianca Maria 
Published: August 2016

SummaryOnychomycosis is the most common nail disease and affects large parts of the population. Psoriasis is a frequently encountered skin disorder with nail involvement being found in up to 80% of the patients at some time of the course of the disease. It has been postulated that onychomycosis occurs more frequently in patients with nail psoriasis, but the results of studies in the literature are controversial. Moreover, onychomycosis could exacerbate psoriasis through Koebner phenomenon and the treatment of psoriasis could predispose to onychomycosis. Finally, the differential diagnosis could be a real challenge due to many same clinical signs, the high prevalence and the possible coexistence of the two diseases. This article attempts to enlighten all these different aspects of a very close relationship.
Effect of antihypertensive therapy with angiotensin‐converting enzyme inhibitors on chronic periodontitis: a case–control study
Authors: Rodrigues M , Barbirato D , Luiz RR , Scharfstein J , Salles GF , Feres‐Filho EJ 
Published: August 2016

BackgroundAngiotensin‐converting enzyme (ACE) downregulates the activity of bradykinin, a potent proinflammatory and immunostimulatory peptide liberated from an internal portion of kininogens. Here, we asked whether periodontitis is worsened in patients under antihypertensive treatment with ACE inhibitors.MethodsPeriodontal parameters were recorded from 30 individuals taking ACE inhibitors (case) and 35 taking a non‐ACE inhibitor medication (control). Data were analyzed by nonparametric and parametric statistical tests.ResultsMost sociodemographic figures were similar in both groups. However, family income was statistically higher in the control group, and the percentage of sites with visible plaque (PL) was statistically higher in the case group (P = 0.043 and P = 0.005, respectively). The prevalence of individuals with chronic periodontitis varied from 31.5% in the control group to 63.4% in the case group (P = 0.001). Patients in the case group presented a 3.2‐fold higher risk of having sites with pocket depth ≥5 mm and a 2.9‐fold higher risk of having sites with clinical attachment loss ≥5 mm in comparison with those in the control group (P = 0.009 and P = 0.001, respectively; adjusted for family income and visible PL).ConclusionAngiotensin‐converting enzyme inhibitors may increase the prevalence and extent of chronic periodontitis in Brazilian patients.
Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation‐induced Photo‐damage
Authors: Li Huaping , Gao Aili , Jiang Na , Liu Qing , Liang Bihua , Li Runxiang , Zhang Erting , Li Zhenjie , Zhu Huilan 
Published: August 2016

AbstractUltraviolet B (UVB) irradiation is one of the most dangerous insults for skin and causes sunburn, erythema, photoaging and photocarcinogenesis. Curcumin (diferuloylmethane), a yellow spice derived from dried rhizomes of Curcuma longa, has been shown to possess significant anti‐inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant and anti‐infective effects. However, the protective effects of curcumin against acute photo‐damage are poorly understood. In this study, we investigated the photoprotective effects of curcumin against UVB‐induced acute photo‐damage in hairless mice and immortalized human keratinocytes (HaCaT). Topical application of curcumin significantly inhibited acute UVB (540 mJ cm−2, for 3 successive days)‐induced inflammatory cells, collagen accrementition derangement and lipid peroxidation, and effectively induced NF‐E2‐related factor 2 (Nrf2) nuclear accumulation in uncovered (Uncv) hairless mice skin. Treatment of HaCaT cells with curcumin significantly attenuated acute UVB (300 mJ cm−2)‐induced lactate dehydrogenase release, intracellular reactive oxygen species production and DNA damage, activated the expression of the phase II detoxifying enzymes and promoted DNA repair activity. The photoprotective effect provided by curcumin was potential associated with modulation of Nrf2‐dependent antioxidant response. Our study suggested that curcumin is a potential agent for preventing and/or treating UV radiation‐induced acute inflammation and photoaging.
Kingdon's “Streams” Model at Thirty: Still Relevant in the 21st Century?
Authors: Rawat Pragati , Morris John Charles 
Published: August 2016

John Kingdon's multiple‐streams model, developed to explain the policy formulation process, is often cited in the policy literature, and remains a staple of policy courses. In spite of critiques suggesting Kingdon's work is theoretically shaky and difficult to observe empirically, the work seems to retain a prominent place in the policy literature, garnering hundreds of citations since its publication. This article provides a review of the literature employing Kingdon's work, from 1984 to the present. The results show that the model has been used across all inhabited continents but suggest a decline in the use of the model in the U.S. scholarly literature. Other theories are liberally used in conjunction with Kingdon's model. The study provides an update on recent trends in the model's use and offers guidelines for interested researchers about topics that are considered as a productive endeavor, going forward.Related Articles

Knutsen, Wenjue Lu. 2012. “.” Politics & Policy 40 (): 161‐192. http://onlinelibrary.wiley.com/doi/10.1111/j.1747-1346.2011.00339.x/abstract

Weiner, Terry. 2007. “.” Politics & Policy 35 (): 872‐897. http://onlinelibrary.wiley.com/doi/10.1111/j.1747-1346.2007.00087.x/abstract

David, Charles‐Philippe. 2015. “.” Politics & Policy 43 (): 163‐195. http://onlinelibrary.wiley.com/doi/10.1111/polp.12106/abstract
Related Media

Kingdon, John W. https://en.wikiquote.org/wiki/John_W._Kingdon

Dow, Katheryn. 2013. https://www.youtube.com/watch?v=s-wIyS-hFNI

. 2015. https://www.youtube.com/watch?v=JUlvyBVoJiI
Constitutional Definition of the Demos and Inter‐Ethnic Relations
Authors: Koos Agnes Katalin 
Published: August 2016

The study reveals some conceptual differences inherent in the world's active constitutions as they relate to defining the country's population. The basic classification question asks whether the population of the state (“demos”) is conceptualized as a communally homogeneous or heterogeneous entity. An inquiry into the texts of more than 167 constitutions evidenced a wide gamut of answers, and an emerging trend toward endorsing the accommodation of diversities, as opposed to expecting and aiming at homogenization. A descriptive section presents the constitutional conceptualizations of the countries’ ethnic makeup, then some concerns about the real‐world potency of the ideals enshrined in constitutions are addressed. The demos concepts are studied in their relationship with the pertinent policy choices, and contemplated in their causal context connecting the objective country features, such as communal fractionalization and development level, with the resulting constellations of communal cooperation versus hostility.Related ArticlesNohlen,Dieter.2009. “.”Politics & Policy37():3‐30.http://onlinelibrary.wiley.com/doi/10.1111/j.1747-1346.2008.00159.x/abstractScott,Gregory M.1994. “.”Southeastern Political Review22():643‐667.http://onlinelibrary.wiley.com/doi/10.1111/j.1747-1346.1994.tb00399.x/abstractRelated MediaConstitute – The World's Constitutions to Read, Search, and Compare.https://www.constituteproject.org/Linguistic Arrangements in the World (L'aménagement linguistique dans le monde).http://www.axl.cefan.ulaval.ca/
Assessing the Impact of District Primary Education Program in India
Authors: Azam Mehtabul , Saing Chan Hang 
Published: August 2016

AbstractWe examine the impact of India's District Primary Education Program (DPEP) introduced in the mid‐1990s. We exploit the fact that the DPEP was targeted towards primary school age children and was introduced in phases to different districts in India, and many of the districts never got the program to implement a difference‐in‐difference strategy to find the causal impact of the program on probability of attended primary school, probability of completed primary education and years of schooling. We find that the DPEP program increased the probability of attended primary school and completed primary school by about 2 percentage points. Similarly, the program increased the years of schooling by 0.16 years.
Global Inequality: Relatively Lower, Absolutely Higher
Authors: Niño‐Zarazúa Miguel , Roope Laurence , Tarp Finn 
Published: August 2016

AbstractThis paper measures trends in global interpersonal inequality during 1975–2010 using data from the most recent version of the World Income Inequality Database (WIID). The picture that emerges using ‘absolute,’ and even ‘centrist’ measures of inequality, is very different from the results obtained using standard ‘relative’ inequality measures such as the Gini coefficient or Coefficient of Variation. Relative global inequality has declined substantially over the decades. In contrast, ‘absolute’ inequality, as captured by the Standard Deviation and Absolute Gini, has increased considerably and unabated. Like these ‘absolute’ measures, our ‘centrist’ inequality indicators, the Krtscha measure and an intermediate Gini, also register a pronounced increase in global inequality, albeit, in the case of the latter, with a decline during 2005 to 2010. A critical question posed by our findings is whether increased levels of inequality according to absolute and centrist measures are inevitable at today's per capita income levels. Our analysis suggests that it is not possible for absolute inequality to return to 1975 levels without further convergence in mean incomes among countries. Inequality, as captured by centrist measures such as the Krtscha, could return to 1975 levels, at today's domestic and global per capita income levels, but this would require quite dramatic structural reforms to reduce domestic inequality levels in most countries.
Reproductive Endocrinology in Chronic Kidney Disease Patients: New Approaches to Old Challenges
Authors: Onder Songul , Akbar Sana , Schmidt Rebecca J. 
Published: August 2016

AbstractSexual dysfunction is a common yet underreported problem among chronic kidney disease (CKD) patients. This article will review sexual dysfunction in both genders, pregnancy outcomes, and best practices for successful full‐term pregnancy in patients with CKD, including those with dialysis dependence and kidney transplants.
Foreign Acquisitions and Target Firms' Performance in China
Authors: Liu Qing , Lu Ruosi , Qiu Larry D. 
Published: August 2016

AbstractThis paper empirically investigates the effects of foreign acquisitions on several performance measures of Chinese target firms. Using a self‐constructed database that includes information on foreign acquisitions in China and the accounting information of Chinese manufacturing firms from 1998 to 2007, we find that foreign acquisitions significantly improve the productivity, sales and fixed asset investment of the target firms. We address the potential endogeneity issue in the OLS estimation using the difference‐in‐differences technique, with two control groups, namely the would‐be targets and the propensity‐score‐matched targets. We also find that the performance‐enhancing effect of foreign acquisitions becomes stronger when larger technology gaps are observed between the acquirers and the targets. An inverted‐U relationship is observed between the post‐acquisition performance of the target firms and the target firm equity that is held by the foreign acquirers. The performance effects are qualitatively different among vertical, horizontal and conglomerate acquisitions.
BCL2 and MYC are expressed at high levels in canine diffuse large B‐cell lymphoma but are not predictive for outcome in dogs treated with CHOP chemotherapy
Authors: Curran K. M. , Schaffer P. A. , Frank C. B. , Lana S. E. , Hamil L. E. , Burton J. H. , Labadie J. , Ehrhart E. J. , Avery P. R. 
Published: August 2016

AbstractDiffuse large B‐cell lymphoma (DLBCL) is the most common haematopoietic malignancy in dogs. Recently, MYC and BCL2 expression levels determined with immunohistochemistry (IHC) were found to be prognostic in people with DLBCL. We hypothesized that canine DLBCL can be similarly subdivided into prognostic subtypes based on expression of MYC and BCL2. Cases of canine DLBCL treated with CHOP chemotherapy were retrospectively collected and 43 dogs had available histologic tissue and complete clinical follow‐up. Median values of percent immunoreactive versus immunonegative cells were used to determine positive or negative expression status. Completion of CHOP was significantly associated with a positive outcome. Compared with human patients, our canine DLBCL patients had high IHC expression of both MYC and BCL2, and relative expression levels of one or both markers were not associated with clinical outcome.
Complete Genome Sequence of a
Gluconacetobacter hansenii
ATCC 23769 Isolate, AY201, Producer of Bacterial Cellulose and Important Model Organism for the Study of Cellulose Biosynthesis
Authors: Pfeffer Sarah , Mehta Kalpa , Brown R. Malcolm 
Published: August 2016

ABSTRACT

The cellulose producer and model organism used for the study of cellulose biosynthesis,
Gluconacetobacter hansenii
AY201, is a variant of
G. hansenii
ATCC 23769. We report here the complete nucleotide sequence of
G. hansenii
AY201, information which may be utilized to further the research into understanding the genes necessary for cellulose biosynthesis.
Draft Genome Sequence of Highly Rifampin-Resistant
Propionibacterium namnetense
NTS 31307302
T
Isolated from a Patient with a Bone Infection
Authors: Aubin Guillaume Ghislain , Kambarev Stanimir , Bémer Pascale , Lawson Paul A. , Corvec Stéphane 
Published: August 2016

ABSTRACT

Propionibacterium namnetense
was recently described as a potential bone pathogen, which is closely related to
Propionibacterium acnes
, a skin commensal microorganism. Here, we report the draft genome sequence of the highly rifampin-resistant strain NTS 31307302
T
isolated from a patient with a tibia infection.
Draft Genome Sequence of
Chelatococcus sambhunathii
Strain HT4
T
(DSM 18167
T
) Isolated from a Hot Spring in India
Authors: Badhai Jhasketan , Whitman William B. , Das Subrata K. 
Published: August 2016

ABSTRACT

The moderately thermophilic bacterium
Chelatococcus sambhunathii
strain HT4
T
was isolated from hot spring sediment. Based upon the draft genome sequence, the genome is 4.4 Mb and encodes 4,147 proteins.
Richmond Wellbeing Service Access Strategy for Older Adults
Authors: Gowling Sarah , Persson Jennie , Holt Genevieve , Ashbourne Sue , Bloomfield James , Shortland Hannah , Bate Clare 
Published: August 2016

IAPT (Improving Access to Psychological Therapies) is a national programme aimed at increasing availability of evidence based psychological therapies in the NHS. IAPT is primarily for people who have mild to moderate, common mental health difficulties such as depression, anxiety, phobias and post traumatic stress disorder (PTSD). The programme seeks to use the least intrusive method of care possible to treat people at the time when it will be of most help to them. Individuals are able to self-refer into most IAPT services or alternatively can request to be referred by their GP or other services in the community.Richmond Wellbeing Service (RWS) is one such IAPT Service and this research is based on our work to promote accessibility of the service to one of the harder to reach population groups - older adults. We know that IAPT services could have a positive impact on older adults as it is believed on average, 25% of over 65 year olds face common mental health problems. However, only a third of these people discuss this with their GP and so are less likely to be referred to an IAPT Service.In relation to the above, this project was designed to look at increasing access for older adults into Richmond Wellbeing Service (RWS) specifically to improve access to the RWS by older adults by 100. The overall goal was to increase older adult (65+) referral rates by 20% over a year, in raw number this would translate to an increase of 100 over a year period, and in percentage terms an average of 8% of total referrals.Results yielded an increase of 39 referrals between baseline and test period. The majority of this increase had occurred in the final five months of the projects duration(31). Interestingly the number of older adults in the older age band (85+) almost doubled within this period (from 12 to 21). In total, in percentage terms this translates to an an increase of OA referrals from 6% up to 6.7%, as above we are aiming for 8% or an additional increase of 61 patients. Thus during the duration of the project there were signals of an increase in the desired direction, as the number of OA referrals increased following the period of time the interventions were implemented. However referral rates did not fully reach the target set.The authors concluded that sustainable and meaningful change in improving access for older adults into an IAPT service is possible but does take time. (Alongside the increase of referral a continous assessment of quality is required and where neccessary improve upon the appropriateness of the service offered to Older adults).
Interest of convex spherical anamorphosis in better understanding of brain AVMs' angioarchitecture
Authors: Clarençon Frédéric , Maizeroi-Eugène Franck , Maingreaud Flavien , Bresson Damien , Ayoub David , Sourour Nader-Antoine , Menjot de Champfleur Nicolas , Chiras Jacques , Yardin Catherine , Mounayer Charbel 
Published: August 2016

IntroductionConvex spherical anamorphosis is a barrel distortion that consists of the application of a plane surface on a convex hemisphere. Applied in vascular imaging of brain arteriovenous malformations (bAVMs), this deformation may help to ‘spread’ the nidus and surrounding vessels (arteries/veins) and thus to differentiate the different components of bAVMs more accurately.MethodsThe imaging data from 15 patients (8 male, 7 female; 14 supratentorial bAVMs, 1 infratentorial) were used to test the algorithm. The algorithm was applied to three-dimensional rotational angiography (3D-RA) volume rendering reconstructions in anteroposterior, lateral and oblique views and compared with regular 3D-RA and DSA. Arterial feeder and draining vein count and quality visualization of the main draining vein and intranidal aneurysms were compared between the three imaging techniques.ResultsAnamorphosis was able to depict more arterial feeders than 3D-RA alone (p=0.027). There was no statistically significant difference between 6 f/s DSA and anamorphosis for arterial feeder count. No difference was observed in draining vein count between the three imaging modalities. Visualization of the precise origin of the main draining vein was considered to be good in 67% of the cases with anamorphosis versus 47% and 33% for 6 f/s DSA and 3D-RA alone, respectively. Intranidal aneurysms were accurately depicted by anamorphosis (2 cases), whereas 6 f/s DSA and 3D-RA showed doubtful images in one and two additional cases, respectively, which were finally confirmed as focal venous ectasias on supraselective injection.ConclusionsAnamorphosis can help to visualize more precisely the main draining vein origin of the bAVM and depict more accurately intranidal aneurysms.
Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner
Authors: Jokić Mladen , Vlašić Ignacija , Rinneburger Miriam , Klümper Niklas , Spiro Judith , Vogel Wenzel , Offermann Anne , Kümpers Christiane , Fritz Christian , Schmitt Anna , Riabinska Arina , Wittersheim Maike , Michels Sebastian , Ozretić Luka , Florin Alexandra , Welcker Daniela , Akyuz Mehmet Deniz , Nowak Michael , Erkel Martin , Wolf Jürgen , Büttner Reinhard , Schumacher Björn , Thomale Jürgen , Persigehl Thorsten , Maintz David , Perner Sven , Reinhardt Hans Christian 
Published: August 2016

Abstract
KRAS-mutant lung adenocarcinoma is among the most common cancer entities and, in advanced stages, typically displays poor prognosis due to acquired resistance against chemotherapy, which is still largely based on cisplatin-containing combination regimens. Mechanisms of cisplatin resistance have been extensively investigated, and ERCC1 has emerged as a key player due to its central role in the repair of cisplatin-induced DNA lesions. However, clinical data have not unequivocally confirmed ERCC1 status as a predictor of the response to cisplatin treatment. Therefore, we employed an autochthonous mouse model of Kras-driven lung adenocarcinoma resembling human lung adenocarcinoma to investigate the role of Ercc1 in the response to cisplatin treatment. Our data show that Ercc1 deficiency in Tp53-deficient murine lung adenocarcinoma induces a more aggressive tumor phenotype that displays enhanced sensitivity to cisplatin treatment. Furthermore, tumors that relapsed after cisplatin treatment in our model develop a robust etoposide sensitivity that is independent of the Ercc1 status and depends solely on previous cisplatin exposure. Our results provide a solid rationale for further investigation of the possibility of preselection of lung adenocarcinoma patients according to the functional ERCC1- and mutational TP53 status, where functionally ERCC1-incompetent patients might benefit from sequential cisplatin and etoposide chemotherapy.
Implications: This study provides a solid rationale for the stratification of lung adenocarcinoma patients according to the functional ERCC1- and mutational TP53 status, where functionally ERCC1-incompetent patients could benefit from sequential cisplatin and etoposide chemotherapy. Mol Cancer Res; 14(11); 1110–23. ©2016 AACR.
Unifying Algorithm for Mechanistic Diagnosis of Atrial Tachycardia
Authors: Liu Christopher F. , Cheung Jim W. , Ip James E. , Thomas George , Yang Hua , Sharma Sandeep , Markowitz Steven M. , Lerman Bruce B. 
Published: August 2016

Background—
No existing criteria unequivocally differentiate focal atrial tachycardia (AT) caused by microreentry, triggered activity, or enhanced automaticity. Although macroreentrant AT is readily diagnosed based on entrainment criteria, the smaller circuit dimension associated with microreentrant AT makes it challenging to validate the presence of reset with fusion. An algorithm was, therefore, developed that is independent of entrainment but which reliably identifies specific mechanisms of focal AT.

Methods and Results—

Fifty-nine patients with AT underwent adenosine testing after mapping of tacycardia. Ten ATs had nonfocal activation, with ≥90% of tachycardia cycle length identified with electroanatomical mapping, findings consistent with macroreenty. All ATs were insensitive to adenosine. Forty-nine patients had focal AT with centrifugal activation. In 32/49 (67%) ATs, electrograms were nonfractionated, and <50% of tachycardia cycle length could be mapped. Based on programmed stimulation, 26/32 (81%) of these ATs were classified as due to triggered activity and 6/32 (19%) as due to enhanced automaticity. Adenosine terminated 100% of triggered ATs and transiently slowed or suppressed 100% of automatic ATs. The remaining 17 focal ATs had localized fractionated electrograms (≥35% of tachycardia cycle length) at the site of successful ablation and were classified as microreentrant. Adenosine had no effect in these ATs. The response to adenosine accurately differentiated all subtypes of focal AT,
P
<0.05.

Conclusions—
Adenosine-sensitivity (termination or transient slowing/suppression) in response to adenosine was 100% sensitive and specific for identifying focal AT mechanisms due to triggered activity or automaticity, respectively. Absence of adenosine effect on focal AT identifies tachycardia due to microreentry.