bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bipolar disorder among individuals with atopic dermatitis: a case–control study in the All of Us Research Program
Authors: Wride Anthony Mitchel , Chen Gloria F , Fan Ryan , Leasure Audrey C , Jones Stephen Scott , Levey Daniel F , Damsky William , Cohen Jeffrey M 
Published: October 2024

Abstract

Background
Atopic dermatitis (AD) has been associated with psychiatric comorbidities.

Objectives
To characterize the association between AD and bipolar disorder (BPD) with a case–control study of the National Institutes of Health All of Us Research Program.

Methods
We used Systematized Nomenclature of Medicine diagnostic codes to identify cases of AD. Four age-, sex- and race/ethnicity-matched controls were found for each case using propensity score matching. After controlling for age, sex, race/ethnicity, income, smoking status and depression, the relationship between AD and BPD was evaluated using logistic regression.

Results
We identified 13 431 AD cases and 53 724 matched controls. Participants with AD were more likely than controls to have BPD (7.8% vs. 4.6%, P &lt; 0.001). After adjusting for demographics and comorbidities, we observed a significant association (odds ratio 1.49, 95% confidence interval 1.37–1.62; P &lt; 0.001).

Conclusions
Compared with individuals without AD, individuals with AD have 1.49-fold increased odds of having BPD. Further investigation is needed to gain a better understanding of this association.
Bidirectional association of sleep disorders with chronic kidney disease: a systematic review and meta-analysis
Authors: Koh Jin Hean , Lim Claire Yi Jia , Yam Kvan Jie Ming , Yeo Brian Sheng Yep , Ng Adele Chin Wei , Loh Shaun Ray Han , Hsu Pon Poh , Gooley Joshua , Tan Chieh Suai , Toh Song Tar 
Published: October 2024

ABSTRACT

Background
Published studies have suggested a link between chronic kidney disease (CKD) and sleep disorders, although the exact nature of this association has not been uniformly described. Clarifying this relationship may facilitate evidence-based interventions that address the interplay between these disease entities. Such interventions could prevent obstructive sleep apnea (OSA) from worsening CKD and improve the quality of life for CKD patients by reducing the risk of developing OSA. Therefore, the objective of this meta-analysis is to assess the bidirectional association between sleep disorders and CKD.

Methods
Following a PROSPERO-registered protocol, three blinded reviewers conducted a systematic review of the Medline/PubMed, Embase, Cochrane Library and Cumulative Index of Nursing and Allied Health (CINAHL) databases for observational studies pertaining to the relationship between sleep disorders and CKD. A meta-analysis was conducted in risk ratios (RRs).

Results
From 63 studies (26 777 524 patients), OSA [RR 1.68; 95% confidence interval (CI) 1.45 to 1.93], albuminuria (RR 1.54; 95% CI 1.18 to 1.99), restless leg syndrome (RLS) (RR 1.88; 95% CI 1.48 to 2.38) and insomnia (RR 1.24; 95% CI 1.01 to 1.54) were significantly associated with CKD. There was a significant association between OSA (RR 1.77; 95% CI 1.56 to 2.01) with incident CKD. There was a significant association of OSA (RR 1.74; 95% CI 1.55 to 1.96), RLS (RR 1.73; 95% CI 1.32 to 2.25) and insomnia (RR 1.14; 95% CI 1.03 to 1.27) in patients with CKD compared with healthy controls. CKD was also significantly associated with incident OSA (RR 1.60; 95% CI 1.35 to 1.89).

Conclusion
The bidirectional associations of obstructive sleep apnea with CKD remained consistent across different stages of CKD, modes of diagnosis of sleep disorder and geographical region. A bidirectional association was observed between CKD and obstructive sleep apnea, RLS and insomnia. The treatment of sleep disorders may reduce the risk of CKD, and vice versa.
SesamumGDB: a comprehensive platform for Sesamum genetics and genomics analysis
Authors: Hengchun Cao , Hui Guo , Weifei Yang , Guiting Li , Ming Ju , Yinghui Duan , Qiuzhen Tian , Qin Ma , Xiaoxu Feng , Zhanyou Zhang , Haiyang Zhang , Hongmei Miao 
Published: October 2024

Abstract
Sesame (Sesamum indicum L., 2n = 26) is a crucial oilseed crop cultivated worldwide. The ancient evolutionary position of the Sesamum genus highlights its value for genomics and molecular genetics research among the angiosperms of other genera. However, Sesamum is considered a small orphan genus with only a few genomic databases for cultivated sesame to date. The urgent need to construct comprehensive, curated genome databases that include genus-specific gene resources for both cultivated and wild Sesamum species is being recognized. In response, we developed Sesamum Genomics Database (SesamumGDB), a user-friendly genomic database that integrates extensive genomic resources from two cultivated sesame varieties (S. indicum) and seven wild Sesamum species, covering all three chromosome groups (2n = 26, 32, and 64). This database showcases a total of 352 471 genes, including 6026 related to lipid metabolism and 17 625 transcription factors within Sesamum. Equipped with an array of bioinformatics tools such as BLAST (basic local alignment search tool) and JBrowse (the Javascript browser), SesamumGDB facilitates data downloading, screening, visualization, and analysis. As the first centralized Sesamum genome database, SesamumGDB offers extensive insights into the genomics and genetics of sesame, potentially enhancing the molecular breeding of sesame and other oilseed crops in the future.
Database URL: http://www.sgbdb.com/sgdb/
The effective elastic thickness along the Emperor Seamount Chain and its tectonic implications
Authors: Watts Anthony B , Wessel Pål , Xu Chong 
Published: October 2024

SUMMARY
The Hawaiian–Emperor Seamount Chain, a pre-eminent example of a hotspot-generated intraplate seamount chain, provides key constraints not only on the kinematics of plates but also on their rigidity. Previous studies have shown that the effective elastic thickness, Te, a proxy for the long-term strength of the lithosphere, changes abruptly at the Hawaiian–Emperor ‘bend’ from low values (∼16 km) at the Emperor Seamounts to high values (∼27 km) at the Hawaiian Ridge. To better constrain Te along the poorly explored Emperor Seamounts we have used a free-air gravity anomaly and bathymetry gridded data set, together with fully 3-D elastic plate (flexure) models, to estimate the continuity of Te and volcano load and infill densities along 1000 profiles spaced 2 km apart of the chain. Results show that Te generally decreases northwards along the chain. The decrease is most systematic between Ojin and Jimmu guyots where Te depends on the age of the lithosphere at the time of volcano loading and is controlled by the 340 and 400 °C oceanic isotherms. The largest variation from these isotherms occurs at the northern and southern ends of the chain where Te is smaller than expected suggesting the influence of pre-existing, older, loads. We use these results to constrain the subsidence, flexural tilt, rheological properties and tectonic setting along the seamount chain. We found an excess subsidence in the range 1.2–2.4 km, a tilt as large as 2–3°, oceanic lithosphere that is weaker than it is seawards of the weak zone at subduction zones, and a tectonic setting at Detroit and Koko seamounts that, despite their forming an integral part of the hotspot generated seamount chain, retains a memory of their proximity to earlier loads associated with plume influenced mid-oceanic ridges.
Sense or Sensibility? Netizens’ Choice of Social Media Comments in an Authoritarian Regime
Authors: Wong Stan Hok-Wui , Liang Jiachen 
Published: October 2024

Abstract
While the Internet in China is subjected to heavy state regulations, Chinese netizens can still access online comments that deviate from official discourse on many issues. To prevent online discussions from getting out of hand, the Chinese government uses soft propaganda such as online comments to channel public opinions. Which type of online comments appeal to Chinese netizens? Using a survey experimental design, we examine the appeal of 4 distinct types of online comments on certain policies. We find that our survey respondents spend significantly more time in consuming emotional comments that deviate from official discourse. When it comes to the effect on attitude, however, we find that deviating-emotional comments are no more persuasive than deviating-informational comments. Our results call into question the effectiveness of China’s state propaganda in channeling online public opinions while highlighting the importance of alternative information in shaping public opinions in an authoritarian context.
Multicenter randomized phase III study of high-dose therapy with autologous stem cell transplantation versus observation for patients with newly diagnosed peripheral T-cell lymphoma who achieved complete metabolic response after induction therapy (JCOG2210, TRANSFER study)
Authors: Kita Ryosuke , Shimada Kazuyuki , Machida Ryunosuke , Sekita Tetsuya , Sasaki Keita , Ishitsuka Kenji , Fukuda Haruhiko , Maruyama Dai , Munakata Wataru , Nagai Hirokazu ,   Japan Clinical Oncology Group Lymphoma Study Group
Published: October 2024

Abstract
Patients with peripheral T-cell lymphoma demonstrated a poor prognosis after obtaining a complete response with induction treatment compared to those with B-cell lymphoma. Once it relapsed, curative treatment is frequently limited to invasive treatments with significant treatment-related mortality, including allogeneic stem cell transplantation. The limitations of these treatment choices indicate the necessity for developing optimal consolidation therapies to prevent relapse. This multicenter randomized phase III trial aims to confirm the superiority of the high-dose therapy with autologous stem cell transplantation over observation alone in terms of progression-free survival for patients with newly diagnosed peripheral T-cell lymphoma who achieved complete metabolic response after induction therapy. A total of 140 patients from 52 hospitals will be enrolled in Japan over 5.5 years. This trial is registered in the Japan Registry of Clinical Trials as jRCTs031240169 (https://jrct.niph.go.jp/latest-detail/jRCTs031240169).
Genetic architecture of phosphorus use efficiency across diverse environmental conditions: insights from maize elite and landrace lines
Authors: Roller Sandra , Würschum Tobias 
Published: October 2024

Abstract
Phosphorus is an essential nutrient for all crops. Thus, a better understanding of the genetic control of phosphorus use efficiency evident in physiological, developmental, and morphological traits and its environmental plasticity is required to establish the basis for maintaining or enhancing yield while making agriculture more sustainable. In this study, we utilized a diverse panel of maize (Zea mays L.), including 398 elite and landrace lines, phenotyped across three environments and two phosphorus fertilization treatments. We performed genome-wide association mapping for 13 traits, including phosphorus uptake and allocation, that showed a strong environment dependency in their expression. Our results highlight the complex genetic architecture of phosphorus use efficiency as well as the substantial differences between the evaluated genetic backgrounds. Despite harboring more of the identified quantitative trait loci, almost all of the favorable alleles from landraces were found to be present in at least one of the two elite heterotic groups. Notably, we also observed trait-specific genetic control even among biologically related characteristics, as well as a substantial plasticity of the genetic architecture of several traits in response to the environment and phosphorus fertilization. Collectively, our work illustrates the difficulties in improving phosphorus use efficiency, but also presents possible solutions for the future contribution of plant breeding to improve the phosphorus cycle.
Studying binary systems in Omega Centauri with MUSE – I. Detection of spectroscopic binaries
Authors: Wragg F , Kamann S , Saracino S , Latour M , Dreizler S , Martens S , Seth A , Vaz D , van de Ven G 
Published: October 2024

ABSTRACT
NGC 5139 ($\omega$ Cen) is the closest candidate of a nuclear star cluster that has been stripped of its host galaxy in the Milky Way. Despite extensive studies through the last decades, many open questions about the cluster remain, including the properties of the binary population. In this study, we use MUSE multi-epoch spectroscopy to identify binary systems in $\omega$ Cen. The observations span 8 yr, with a total of 312 248 radial velocity measurements for 37 225 stars. Following the removal of known photometric variables, we identify 275 stars that show RV variations, corresponding to a discovery fraction of $1.4\pm 0.1~{{\ \rm per\ cent}}$. Using dedicated simulations, we find that our data are sensitive to $70 \pm 10~{{\ \rm per\ cent}}$ of the binaries expected in the sample, resulting in a completeness-corrected binary fraction of $2.1\pm 0.4~{{\ \rm per\ cent}}$ in the central region of $\omega$ Cen. We find similar binary fractions for all stellar evolutionary stages covered by our data, the only notable exception being the blue straggler stars, which show an enhanced binary fraction. We also find no distinct correlation with distance from the cluster centre, indicating a limited amount of mass segregation within the half-light radius of $\omega$ Cen.
Wavelet analysis of low-frequency quasi-periodic oscillations in MAXI J1803−298 observed with Insight-HXMT and NICER
Authors: Jin Y J , Chen X , Zhu H F , Jiang Z J , Zhang L , Wang W 
Published: October 2024

ABSTRACT
With data observed by the Hard X-ray Modulation Telescope (Insight-HXMT) and the Neutron star Interior Composition Explorer (NICER), we study low-frequency quasi-periodic oscillations (QPOs) of the black hole candidate MAXI J1803−298 during the 2021 outburst. Based on the hardness–intensity diagram and the difference in the QPOs properties, type-C and type-B QPOs are found in the low-hard state and soft-intermediate state, respectively. After searching for and classifying QPOs in the Fourier domains, we extract the QPO component and study it with wavelet analysis. The QPO and no-QPO time intervals are separated by the confidence level, so that the S-factor, which is defined as the ratio of the QPO time interval to the total length of the good time interval, is calculated. We found S-factors decrease with QPOs frequency for type-C QPOs but stay stable around zero for type-B QPOs. The relation of S-factor of type-C QPOs and photon energy and the correlation of S-factor and counts are also studied. Different correlations between the S-factor and counts for different energy bands indicate different origins of QPOs in high- and low-energy bands, which may be due to a dual-corona scenario.
Homeworking experiences of neuro-divergent workers: systematic review
Authors: Brooks S K , Hall C E , Rogers M B , Greenberg N 
Published: October 2024

Abstract

Background
Working from home (WFH) is becoming more common, but little is known about how it specifically affects neuro-divergent workers’ psychological and occupational well-being.

Aims
This review aimed to explore the experiences of neuro-divergent staff WFH, including the challenges they face; the potential benefits of homeworking for this specific population and the support systems they require.

Methods
We searched six electronic databases, as well as reference lists of included papers, one preprint server and Google, for literature on neuro-divergent workers’ experiences of WFH. Results were synthesized using thematic analysis.

Results
We reviewed 25 studies (mostly based on data collected during the coronavirus disease 2019 pandemic), finding very little research statistically analysing the impact of WFH on well-being or productivity, or comparing the impact of WFH across neuro-divergent and neuro-typical populations. The (mostly qualitative) findings showed that neuro-divergent participants described various benefits and challenges of the sensory environment at home; the reduction of commuting; increased flexibility and lack of routine when homeworking; the reduction of ‘masking’ behaviours; lack of in-person social contact and increased use of technology.

Conclusions
The findings emphasize the importance of not assuming a one-size-fits-all approach to homeworking and suggest managers should be mindful of workers’ individual preferences for working whilst ensuring that all employees are appropriately supported. The results can inform future research and provide insights for employers to help them create more inclusive work environments.
Markups and Inequality
Authors: Boar Corina , Midrigan Virgiliu 
Published: October 2024

Abstract
We characterize optimal product market policy in an unequal economy in which firm ownership is concentrated and markups increase with firm market shares. We study the problem of a utilitarian regulator who designs revenue-neutral interventions in the product market. We show that optimal policy increases product market concentration. This is because policies that encourage larger producers to expand improve allocative efficiency, increase the demand for labour and equilibrium wages. We derive these results both in a static Mirrleesian setting in which we impose no constraints on the shape of interventions, as well as in a dynamic economy with wealth accumulation. In our dynamic economy optimal policy reduces wealth and income inequality by redistributing market share and profits from medium-sized businesses, which are primarily owned by relatively rich entrepreneurs, to larger diversified corporate firms.
Gender-specific associations between sleep stages and cardiovascular risk factors
Authors: Taporoski Tâmara P , Beijamini Felipe , Alexandria Shaina J , Aaby David , Krieger Jose E , von Schantz Malcolm , Pereira Alexandre C , Knutson Kristen L 
Published: October 2024

Abstract

Study Objectives
Sleep characteristics are associated with cardiovascular disease (CVD) risk and both sleep and CVD risk vary by gender. Our objective was to examine associations between polysomnographic sleep characteristics and CVD risk after excluding moderate-severe sleep apnea, and whether gender modifies these associations.

Methods
This was a cross-sectional study with at-home polysomnography in adults in Brazil (n = 1102 participants with apnea–hypopnea index (AHI) &lt;15 events/hour). Primary exposures were N3, REM, wake after sleep onset (WASO), arousal index, and AHI, and outcomes were blood pressure (BP) and lipid levels.

Results
Associations between sleep and BP varied by gender. In women, more N3 was associated with lower systolic BP (−0.40 mmHg per 10 minutes, 95% CI: −0.71, −0.09), lower diastolic BP (−0.29 mmHg per 10 minutes, 95% CI: −0.50, −0.07), and lower odds of hypertension (OR 0.94, 95% CI: 0.89, 0.98). In men, more WASO was associated with higher systolic BP (0.41 mmHg per 10 minutes, 95% CI: 0.08, 0.74) and higher odds of hypertension (OR 1.07, 95% CI: 1.01, 1.14). No interactions by gender were observed for lipids. More WASO was associated with lower total cholesterol (−0.71 per 10 minutes, 95% CI: −1.37, −0.05). Higher AHI was associated with higher total cholesterol (+0.97 per event/hour, 95% CI: 0.24, 1.70) and higher LDL (+0.84 per event/hour, 95% CI: 0.04, 1.64).

Conclusions
N3 is more strongly associated with BP in women, which is consistent with other studies demonstrating gender differences in BP control and CVD risk and adds a novel risk factor. Longitudinal and interventional studies are required to determine whether changes in N3 result in BP changes.
Role of mechanosensitive channel Piezo1 protein in intestinal inflammation regulation: A potential target
Authors: Jiang Qinlei , Li Zhenyu , Dang Dan , Wei Jiaqi , Wu Hui 
Published: October 2024

AbstractThe intestine is a hollow tract that primarily transports and digests food. It often encounters mechanical forces and exotic threats, resulting in increased intestinal inflammation attributed to the consistent threat of foreign pathogens. Piezo1, a mechanosensitive ion channel, is distributed broadly and abundantly in the intestinal tissue. It transduces mechanical signals into electrochemical signals and participates in many critical life activities, such as proliferation, differentiation, cell apoptosis, immune cell activation, and migration. Its effect on inflammation has been discussed in detail in systems, such as musculoskeletal (osteoarthritis) and cardiac (myocarditis), but the effects on intestinal inflammation remain unelucidated. Piezo1 regulates mucosal layer and epithelial barrier homeostasis during the complex intestinal handling of foreign antigens and tissue trauma. It initiates and spreads immune responses and causes distant effects of inflammation in the vascular and lymphatic systems, but reports of the effects of Piezo1 in intestinal inflammation are scarce. Therefore, this study aimed to discuss the role of Piezo1 in intestinal inflammation and explore novel therapeutic targets.
Safety Profile of COVID-19 Vaccines in HIV Patients Undergoing ART and Their Impact on Immune Recovery and HIV Reservoirs
Authors: Song Bing , Wang Xinhua , Shen Lin , Cheng Juan , Tian Jing , Zhang Chunjie , Zhao Zhuanghong , Zhou Yuting , Liang Rong , Zhou Zihan , Yang Xinyi , Suo Xuhai , Jiang Tianjun , Huang Huihuang , Guan Qun , Yang Ying , Bai Bingke 
Published: October 2024

Abstract

Background:
While some studies have reported the impact of COVID-19 vaccines on immune recovery and human immunodeficiency virus (HIV) reservoirs in persons living with HIV (PLWH), their findings remain inconsistent. Furthermore, limited data exist on the safety of multiple COVID-19 vaccines among PLWH. This study aimed to investigate the safety of heterological COVID-19 vaccine administration in PLWH receiving antiretroviral treatment (ART) and its effects on HIV reservoirs and immune recovery. Such an investigation can help provide a basis for vaccinations against COVID-19 in PLWH.

Methods:
In this cross-sectional study, PLWH receiving ART were recruited from the outpatient clinic of the Department of Infectious Diseases at the Fifth Medical Center of the Chinese PLA General Hospital from September 1, 2021 to December 31, 2021. Fifty-three PLWH receiving ART were vaccinated against COVID-19, with 35 receiving an inactivated vaccine (IN group) and 18 receiving a recombinant protein (CHO cells) vaccine (CHO group) as the third dose. We assessed the changes in liver and kidney functions, blood lipids, and other laboratory parameters at 0, 1, 2, 4, 7, 8, 10, and 13 months after the first vaccination dose. We also monitored CD4+ and CD8+ T cell counts using flow cytometry at 0, 1, 2, 4, 7, 8, 10, and 13 months after the first vaccination dose, as well as levels of cell-associated HIV DNA (CA HIV DNA) and cell-associated HIV RNA (CA HIV RNA) in peripheral blood using the corresponding quantitative detection kits at 0, 2, and 8 months after the first vaccination dose.

Results:
No severe adverse events related to either type of COVID-19 vaccine were observed in HIV patients, irrespective of their CD4+ T cell levels. Both the IN and CHO groups showed significant increases in CD4+ T cell counts during follow-up, CD4+ T cells increased from 438 ± 45 cells/μL to 557 ± 48 cells/μL in the CHO group, while in the IN group, it increased from 448 ± 34 cells/μL to 572 ± 39 cells/μL (both P < 0.001). CA HIV DNA initially decreased and then increased in both groups. CA HIV RNA levels showed significantly decreased in both group after three doses of vaccination (P < 0.01 in CHO group and P < 0.001 in IN group). CD8+ T cells increased from 608 ± 77 cells/μL to 812 ± 116 cells/μL in the CHO group (P < 0.01), while in the IN group, it increased from 702 ± 71 cells/μL to 852 ± 68 cells/μL(P < 0.001) from baseline to the 13 month of following up.

Conclusion:
Our data suggest that the SARS-CoV-2 booster vaccine is safe for PLWH on ART, although it may affect HIV reservoirs and CD8+ T cell counts.