bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study
Authors: Dempster David W. , Zhou Hua , Recker Robert R. , Brown Jacques P. , Recknor Christopher P. , Lewiecki E. Michael , Miller Paul D. , Rao Sudhaker D. , Kendler David L. , Lindsay Robert , Krege John H. , Alam Jahangir , Taylor Kathleen A. , Janos Boris , Ruff Valerie A. 
Published: February 2016

Abstract

Context:
Denosumab-induced PTH elevation may stimulate early bone formation.

Objective:
Our objective was to evaluate whether denosumab-induced changes of intact PTH (iPTH) result in early anabolic effects according to histomorphometry and bone turnover markers (BTMs) compared with teriparatide, an established anabolic agent.

Design:
This open-label, randomized study used quadruple labeling to label bone before/after treatment, with a transiliac bone biopsy at 3 months.

Setting:
This study took both in both US and Canadian sites.

Participants:
Sixty-nine postmenopausal women with osteoporosis were included.

Interventions:
Teriparatide (20 μg/day) for 6 months and denosumab (60 mg once) were used in this study.

Main Outcome Measure:
Between-treatment comparison of change from baseline to month 3 in cancellous mineralizing surface/bone surface, histomorphometric indices in four bone envelopes, and BTM and iPTH at baseline, 1, 3, and 6 months was undertaken.

Results:
After denosumab, iPTH peaked at month 1 (P &lt; .001), then declined, remaining above baseline through month 6 (P ≤ .01); after teriparatide, iPTH declined at all time points (P &lt; .001). From baseline to month 3, cancellous mineralizing surface/bone surface increased with teriparatide and decreased with denosumab and at month 3, was higher with teriparatide. Similar results were observed in other bone envelopes. BTMs increased from baseline in teriparatide-treated subjects (procollagen type 1 N-terminal propeptide at month 1 and carboxyterminal cross-linking telopeptide of type 1 collagen at month 3); procollagen type 1 N-terminal propeptide and carboxyterminal cross-linking telopeptide of type 1 collagen decreased from baseline at all time points in denosumab-treated subjects.

Conclusions:
Denosumab treatment increased iPTH but inhibited bone formation indices. In contrast, teriparatide treatment decreased iPTH but stimulated bone formation indices. These findings are not consistent with the hypothesis of early indirect anabolic effect with denosumab.
Fos-Zippered GH Receptor Cytosolic Tails Act as Jak2 Substrates and Signal Transducers
Authors: Nespital Tobias , van der Velden Lieke M. , Mensinga Anneloes , van der Vaart Elisabeth D. , Strous Ger J. 
Published: February 2016

AbstractMembers of the Janus kinase (Jak) family initiate the majority of downstream signaling events of the cytokine receptor family. The prevailing principle is that the receptors act in dimers: 2 Jak2 molecules bind to the cytosolic tails of a cytokine receptor family member and initiate Jak-signal transducer and activator of transcription signaling upon a conformational change in the receptor complex, induced by the cognate cytokine. Due to the complexity of signaling complexes, there is a strong need for in vitro model systems. To investigate the molecular details of the Jak2 interaction with the GH receptor (GHR), we used cytosolic tails provided with leucine zippers derived from c-Fos to mimic the dimerized state of GHR. Expressed together with Jak2, fos-zippered tails, but not unzippered tails, were stabilized. In addition, the Jak-signal transducer and activator of transcription signaling pathway was activated by the fos-zippered tails. The stabilization depended also on α-helix rotation of the zippers. Fos-zippered GHR tails and Jak2, both purified from baculovirus-infected insect cells, interacted via box1 with a binding affinity of approximately 40nM. As expected, the Jak kinase inhibitor Ruxolitinib inhibited the stabilization but did not affect the c-Fos-zippered GHR tail-Jak2 interaction. Analysis by blue-native gel electrophoresis revealed high molecular-weight complexes containing both Jak2 and nonphosphorylated GHR tails, whereas Jak2-dissociated tails were highly phosphorylated and monomeric, implying that Jak2 detaches from its substrate upon phosphorylation.
A new role for cofilin in retinal neovascularization
Authors: Kumar Raj , Janjanam Jagadeesh , Singh Nikhlesh K. , Rao Gadiparthi N. 
Published: February 2016

ABSTRACT
Pak1 plays an important role in several cellular processes, including cell migration, but its role in pathological angiogenesis is not known. Here, we have determined its role in pathological retinal angiogenesis using an oxygen-induced retinopathy (OIR) model. VEGFA induced phosphorylation of Pak1 and its effector cofilin in a manner that was dependent on time as well as p38MAPKβ (also known as MAPK11) in human retinal microvascular endothelial cells (HRMVECs). Depletion of the levels of any of these molecules inhibited VEGFA-induced HRMVEC F-actin stress fiber formation, migration, proliferation, sprouting and tube formation. In accordance with these observations, hypoxia induced Pak1 and cofilin phosphorylation with p38MAPKβ being downstream to Pak1 and upstream to cofilin in mouse retina. Furthermore, Pak1 deficiency abolished hypoxia-induced p38MAPKβ and cofilin phosphorylation and abrogated retinal endothelial cell proliferation, tip cell formation and neovascularization. In addition, small interfering RNA (siRNA)-mediated downregulation of p38MAPKβ or cofilin levels in the wild-type mouse retina also diminished endothelial cell proliferation, tip cell formation and neovascularization. Taken together, these observations suggest that, although the p38MAPKβ–Pak1–cofilin axis is required for HRMVEC migration, proliferation, sprouting and tubulogenesis, Pak1–p38MAPKβ–cofilin signaling is also essential for hypoxia-induced mouse retinal endothelial cell proliferation, tip cell formation and neovascularization.
The integrin–collagen connection – a glue for tissue repair?
Authors: Zeltz Cédric , Gullberg Donald 
Published: February 2016

ABSTRACT
The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were originally identified on a subset of activated T-cells, and have since been found to be expressed on a number of cell types including platelets (α2β1), vascular cells (α1β1, α2β1), epithelial cells (α1β1, α2β1) and fibroblasts (α1β1, α2β1). Integrin α10β1 shows a distribution that is restricted to mesenchymal stem cells and chondrocytes, whereas integrin α11β1 appears restricted to mesenchymal stem cells and subsets of fibroblasts. The bulk of the current literature suggests that collagen-binding integrins only have a limited role in adult connective tissue homeostasis, partly due to a limited availability of cell-binding sites in the mature fibrillar collagen matrices. However, some recent data suggest that, instead, they are more crucial for dynamic connective tissue remodeling events – such as wound healing – where they might act specifically to remodel and restore the tissue architecture. This Commentary discusses the recent development in the field of collagen-binding integrins, their roles in physiological and pathological settings with special emphasis on wound healing, fibrosis and tumor–stroma interactions, and include a discussion of the most recently identified newcomers to this subfamily – integrins α10β1 and α11β1.
Features of Competitiveness Calculation of Services Drawing on the Example of &#34;Aeroflot&#34;
Authors: Моргунова  , Morgunova Yelyena 
Published: February 2016

In the article there are results of research of modern problems, which are
devoted to an assessment and ways of increasing of competitiveness of
services of air carriers, for instance, - the leader of the branch - JSC «Aeroflot».
The author found out effective ways for competitiveness improvement aimed
to increase demand for this type of service in the conditions of modern Russian
economy. The complex and complete mechanism of understanding of problems
is created. These problems are closely connected with the analysis of
competitiveness which use allows the enterprise to reach effective results in
realization of goods/services. It also gives the enterprise an opportunity to
use effective methods in practice.
Redefining the Proper Role of Government: Ultimate Definition in Reagan’s First Inaugural
Authors: Jones John M. , Rowland Robert C. 
Published: February 2016

Abstract
This essay examines Ronald Reagan’s first inaugural address. In this speech, Reagan used a strategy of “ultimate definition,” consisting of three components. First, the inaugural articulated a broad ideological worldview that prescribed a very limited role for government as the solution to the economic crisis. Second, it appealed to a value system that co-opted the progressive values of contemporary liberalism. Finally, it contained a powerful narration of that worldview in the form of an individualist story of the American Dream.
TFA and the magical thinking of the “best and the brightest”
Authors: Blumenreich Megan , Rogers Bethany 
Published: February 2016

This article draws on oral history testimonies to examine the experiences of participants in the inaugural 1990 cohort of Teach For America (TFA)—a group of young people dubbed the “best and brightest” of their generation and tasked with “saving” urban education. For 25 years, TFA has operated according to the principle of the “best and brightest,” in which it is assumed that participants’ personal qualities and prior academic achievement can stand in for deep professional knowledge and experience. Yet as our data show, the presumptions—that any “smart” person should be able to pick up teaching by doing it, that there is no specialized knowledge needed in order to teach, and that “outsiders” with little knowledge of a school community and its families can “swoop in” and “rescue” underserved students—ultimately set up and demoralized the participants with whom we spoke when they could not live up to such unrealistic expectations. Through participants’ words and experiences, framed in historical context, we raise questions about the myth of the “best and brightest,” the theory of action promoted by TFA, and what it takes to teach in urban classrooms.
Teach For America’s long arc: A critical race theory textual analysis of Wendy Kopp’s works
Authors: Barnes Michael , Germain Emily , Valenzuela Angela 
Published: February 2016

We read and analyzed 165,000 words and uncover a series of counter-stories buried within a textual corpus, authored by Teach For America (TFA) founder Wendy Kopp (Kopp, 1989, 2001; Kopp & Farr, 2011), that offers insight into the forms of racism endemic to Teach For America. All three counter-stories align with a critical race theory (CRT) framework. Specifically, we answer the following questions: What evidence of institutional and epistemological racism is exposed by a CRT textual analysis of TFA’s founding document and later works by Wendy Kopp? To what extent has TFA appropriated the language of culturally relevant pedagogy, while advancing an uninterrogated neoliberal ideology? And, to what extent does TFA’s contribution to a “culture of achievement” (Kopp & Farr, 2011) constitute an actual “poverty of culture” (Ladson-Billings, 2006a) that enacts real harms on communities of color?
Assessment of Wind Energy Potential in Golestan Province of Iran
Authors: Hashemi-Tilehnoee Mehdi , Khaleghi Masoud , Babayani Dayan 
Published: February 2016

Renewable energy sources are estimated to have a thriving future in many countries as well as Iran. The aim of this work is the evaluation of wind energy potentiality for the five counties of Golestan province in the northern region of Iran. A long term data source, consisting of 30 years in Gorgan, 22 years in Gonbade-e Qabus, 21 years in Maraveh Tappeh, 9 years in Aliabad, and 7 years in Bandar-e Turkaman of eight-hourly mean wind data, was adopted and analyzed. Mean wind power based on quantified data, Weibull distribution function, the relative percentage error (RPE) and wind direction between obtaining values of wind power has been considered. According to these data, it was found that the numerical values of the shape parameter and scale parameter for Golestan varied a tight range. Annual values of ‘‘k’’ ranged from 2.7 to 4.7 where it is constant in different elevation because of better performance of this method in estimating wind energy potential, while annual values of ‘‘c’’ were in the range of 2.6 m/s in 10 m and 7.6 m/s in 40 m. Wind power densities have been estimated and relatively low for large wind turbines. The consequences indicate that in some months Maraveh Tappeh and Bandar-e Turkaman has best wind energy potential, as class 2, in order to establish some small wind turbine models for the sustainable development of Golestan province. Article History: Received Sept 13, 2015; Received in revised form Dec 27, 2015; Accepted January 17, 2016; Available online How to Cite This Article: Babayani, D., Khaleghi, M. and Hashemi-Tilehnoee, M. (2016) Assessment of Wind Energy Potential in Golestan Province of Iran. Int. Journal of Renewable Energy Development, 5(1), 25-31. http://dx.doi.org/10.14710/ijred.5.1.25-31
Design, Analysis and Optimization of a Solar Dish/Stirling System
Authors: Nazemi Seyyed Danial , Boroushaki Mehrdad 
Published: February 2016

In this paper, a mathematical model by which the thermal and physical behavior of a solar dish/Stirling system was investigated, then the system was designed, analysed and optimized. In this regard, all of heat losses in a dish/Stirling system were calculated, then, the output net-work of the Stirling engine was computed, and accordingly, the system efficiency was worked out. These heat losses include convection and conduction heat losses, radiation heat losses by emission in the cavity receiver, reflection heat losses of solar energy in the parabolic dish, internal and external conduction heat losses, energy dissipation by pressure drops, and energy losses by shuttle effect in displacer piston in the Stirling engine. All of these heat losses in the parabolic dish, cavity receiver and Stirling engine were calculated using mathematical modeling in MatlabTM software. For validation of the proposed model, a 10 kW solar dish/Stirling system was designed and the simulation results were compared with the Eurodish system data with a reasonable degree of agreement. This model is used to investigate the effect of geometric and thermodynamic parameters including the aperture diameter of the parabolic dish and the cavity receiver, and the pressure of the compression space of the Stirling engine, on the system performance. By using the PSO method, which is an intelligent optimization technique, the total design was optimized and the optimal values of decision-making parameters were determined. The optimization has been done in two scenarios. In the first scenario, the optimal value of each designed parameter has been changed when the other parameters are equal to the designed case study parameters. In the second scenario, all of parameters were assumed in their optimal values. By optimization of the modeled dish/Stirling system, the total efficiency of the system improved to 0.60% in the first scenario and it increased from 21.69% to 22.62% in the second scenario of the optimization, while the system variables changed slightly. Article History: Received Sept 28, 2015; Received in revised form January 08, 2016; Accepted February 15, 2016; Available online How to Cite This Article: Nazemi, S. D. and Boroushaki, M. (2016) Design, Analysis and Optimization of a Solar Dish/Stirling System. Int. Journal of Renewable Energy Development, 5(1), 33-42. http://dx.doi.org/10.14710/ijred.5.1.33-42
Evaluating wind energy potential in Gorgan–Iran using two methods of Weibull distribution function
Authors: Hashemi-Tilehnoee Mehdi , Babayani Dayan , Khaleghi Masoud 
Published: February 2016

In this study, wind energy characteristics of the, a city in northeast of Iran, measured at 10m height in 2014. The Gorgan airport one hour recorded data extrapolated to 50m height. The data have been statistically analyzed hourly, daily, monthly, seasonally and annually to determine the wind power potential. Weibull distribution function has been used to determine the wind power density and then the potential energy. Standard deviation method and power density method are the methods used to calculate the scaling and shaping parameters of the Weibull distribution function. The annual mean wind power calculated by the standard deviation method and the power density method is 38.98w/m2 and 41.32w/m2, respectively. By comparing the results concluded that the power density method is a better method than the standard deviation method. In addition, Gorgan wind energy potentiality categorized into class 1. So is unsuitable to utilize large wind energy turbine. Article History: Received November 21, 2015; Received in revised form January 15, 2016; Accepted February 10, 2016; Available onlineHow to Cite This Article: Babayani, D., Khaleghi, M., Tashakor, S., and Hashemi-Tilehnoee.,M. (2016) Evaluating wind energy potential in Gorgan–Iran using two methods of Weibull distribution function. Int. Journal of Renewable Energy Development, 5(1), 43-48.http://dx.doi.org/10.14710/ijred.5.1.43-48
Comparison of Flow Curves of AA 5457-O Sheet Material Determined by Hydraulic Bulge and Tensile Tests at Warm Forming Temperatures
Authors: Şükür Emine Feyza , Türköz Mevlüt , Dilmeç Murat , Halkacı Hüseyin Selçuk , Halkacı Mehmet 
Published: February 2016

Abstract
The deformation behavior of sheet materials changes according to temperature. It is possible that the formability of a material for different temperatures is investigated and the flow curves are obtained by using a hydraulic bulge test. Generally, biaxial stress state occurs in real forming processes. Flow curves can be derived from the hydraulic bulge test for the biaxial stress state, and the higher strain values can be achieved in comparison to the tensile test without extrapolation. Hydraulic bulge tests are preferred instead of tensile tests on account of presuming the problems can occur during the formation process of sheet material, being informed about the formability of material at the current pressure and temperature states, and obtaining flow curves to perform more accurate process simulations. In this study, the flow curves for the material AA5754-O were obtained using the warm bulge test and by considering the strain rates. The sections of the curves that can be used in simulation were identified, and these curves were comparatively investigated with respect to the curves obtained from the tensile test. In addition, case studies were performed in order to conduct more realisitic simulations using the results of the flow curves obtained from the bulge and tensile tests.
Coalescent Inference Using Serially Sampled, High-Throughput Sequencing Data from Intrahost HIV Infection
Authors: Dialdestoro Kevin , Sibbesen Jonas Andreas , Maretty Lasse , Raghwani Jayna , Gall Astrid , Kellam Paul , Pybus Oliver G , Hein Jotun , Jenkins Paul A 
Published: February 2016

Abstract
Human immunodeficiency virus (HIV) is a rapidly evolving pathogen that causes chronic infections, so genetic diversity within a single infection can be very high. High-throughput “deep” sequencing can now measure this diversity in unprecedented detail, particularly since it can be performed at different time points during an infection, and this offers a potentially powerful way to infer the evolutionary dynamics of the intrahost viral population. However, population genomic inference from HIV sequence data is challenging because of high rates of mutation and recombination, rapid demographic changes, and ongoing selective pressures. In this article we develop a new method for inference using HIV deep sequencing data, using an approach based on importance sampling of ancestral recombination graphs under a multilocus coalescent model. The approach further extends recent progress in the approximation of so-called conditional sampling distributions, a quantity of key interest when approximating coalescent likelihoods. The chief novelties of our method are that it is able to infer rates of recombination and mutation, as well as the effective population size, while handling sampling over different time points and missing data without extra computational difficulty. We apply our method to a data set of HIV-1, in which several hundred sequences were obtained from an infected individual at seven time points over 2 years. We find mutation rate and effective population size estimates to be comparable to those produced by the software BEAST. Additionally, our method is able to produce local recombination rate estimates. The software underlying our method, Coalescenator, is freely available.
Admixture, Population Structure, and F-Statistics
Authors: Peter Benjamin M 
Published: February 2016

Abstract
Many questions about human genetic history can be addressed by examining the patterns of shared genetic variation between sets of populations. A useful methodological framework for this purpose is F-statistics that measure shared genetic drift between sets of two, three, and four populations and can be used to test simple and complex hypotheses about admixture between populations. This article provides context from phylogenetic and population genetic theory. I review how F-statistics can be interpreted as branch lengths or paths and derive new interpretations, using coalescent theory. I further show that the admixture tests can be interpreted as testing general properties of phylogenies, allowing extension of some ideas applications to arbitrary phylogenetic trees. The new results are used to investigate the behavior of the statistics under different models of population structure and show how population substructure complicates inference. The results lead to simplified estimators in many cases, and I recommend to replace F3 with the average number of pairwise differences for estimating population divergence.