bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Ventilation Tube Placement and Long-term Audiologic Outcome in Children with Cleft Palate
Authors: Kim Elissa , Kanack Melissa D. , Dang-Vu Milan D. , Carvalho Daniela , Jones Marilyn C. , Gosman Amanda A. 
Published: July 2016

Objective The purpose of this study was to assess the effect of ventilation tube (VT) placement on long-term hearing outcomes in children with cleft palate. Study Design Case series with chart review. Setting Genetic and dysmorphology database at Rady Children's Hospital–San Diego (RCHSD). Patients Children with cleft palate diagnosis who underwent surgery at RCHSD between 1995 and 2002. Main Outcome Measure The primary outcome studied was hearing acuity at 10 years of age. Independent variables studied included gender, age at palate repair and first VT placement, total number of VTs, number of complications, and presence of tympanic membrane perforation. Results An increased number of tubes was associated with a greater incidence of hearing loss at age 10, even after adjusting for total number of otologic complications. The timing of initial tube placement did not have a significant effect on long-term hearing outcome in this study. Conclusions While children with worse middle ear disease are more likely to receive more tubes and have long-term conductive hearing loss as a result of ear disease, the results of this study suggest that multiple tube placements may not contribute to improved long-term hearing outcomes. Further research focusing on long-term outcomes is needed to establish patient-centered criteria guiding decision making for ventilation tube placement in children with cleft palate.
Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges
Authors: van Brummelen Emilie M.J. , Ros Willeke , Wolbink Gertjan , Beijnen Jos H. , Schellens Jan H.M. 
Published: July 2016

Abstract
In oncology, an increasing number of targeted anticancer agents and immunotherapies are of biological origin. These biological drugs may trigger immune responses that lead to the formation of antidrug antibodies (ADAs). ADAs are directed against immunogenic parts of the drug and may affect efficacy and safety. In other medical fields, such as rheumatology and hematology, the relevance of ADA formation is well established. However, the relevance of ADAs in oncology is just starting to be recognized, and literature on this topic is scarce. In an attempt to fill this gap in the literature, we provide an up-to-date status of ADA formation in oncology. In this focused review, data on ADAs was extracted from 81 clinical trials with biological anticancer agents. We found that most biological anticancer drugs in these trials are immunogenic and induce ADAs (63%). However, it is difficult to establish the clinical relevance of these ADAs. In order to determine this relevance, the possible effects of ADAs on pharmacokinetics, efficacy, and safety parameters need to be investigated. Our data show that this was done in fewer than 50% of the trials. In addition, we describe the incidence and consequences of ADAs for registered agents. We highlight the challenges in ADA detection and argue for the importance of validating, standardizing, and describing well the used assays. Finally, we discuss prevention strategies such as immunosuppression and regimen adaptations. We encourage the launch of clinical trials that explore these strategies in oncology.
Perinatal Music Therapy and Antenatal Music Classes: Principles, Mechanisms, and Benefits
Authors: Mastnak Wolfgang 
Published: July 2016

ABSTRACTAntenatal music activities are in the ascendant. Regarding evidence-based research, the article advocates 5 main aims: music therapeutic control of pre- and perinatal stress, anxiety, and depression; music-related mental and physical birth preparation comprising cognitive adjustment, emotional regulation, physical activity, relaxation and pain management, and social inclusion; music-associated bonding and self-efficacy; prenatal sound stimulation to trigger learning processes, pedagogical priming and brain maturation; music activities to facilitate the child’s acculturation and adaptive self-regulation. Underlying mechanisms such as neuroplasticity help to understand the multifaceted effects of music in pre- and perinatal care. Individual conditions and features of the mother and her child have to be taken into account and music interventions to be harmonized with complementary perinatal programs.
Integrating animals in the classroom: The attitudes and experiences of Australian school teachers toward animal-assisted interventions for children with Autism Spectrum Disorder.
Authors: Smith Bradley P , Dale Ashley A 
Published: July 2016

The introduction of animals into school classrooms has been posited as a beneficial intervention for individuals with Autism Spectrum Disorder (ASD). Whilst evidence that animal-assisted interventions or activities can positively influence classroom behaviour and learning outcomes is emerging, little is known about the experiences and attitudes of those who implement it. We presented a series of open and close-ended questions via an online survey to Australian school teachers working with students on the autistic spectrum. Whether teachers had experienced companion animals in the classroom or not, companion animals were believed to provide a means for improving social skills and engagement within the classroom, as well as decreasing stress, anxiety, and the occurrence of problematic behaviours. Yet, despite an overall positive attitude, and 68% having had animals or pets in their classroom, only 16% of respondents had experience with ‘formal’ animal-assisted interventions. Explanations for why both formal and informal animal-assisted interventions were either not being adopted, or was not currently being considered, included a lack of knowledge, lack of support and resources, reactions of the student in relation to allergies and behaviour, and issues relating to animal welfare. It was also acknowledged that the evidence-base for animal-assisted interventions for students with ASD is currently lacking, and that such interventions were not suitable for all students, or all classroom situations. Moving forward, it is important that the inclusion of companion animals and more formal based animal intervention programs in classrooms be adequately designed and evaluated, because implementing or promoting time consuming and financially costly strategies without the evidence is problematic.
El Hidróxido de Calcio y los bloques de tierra comprimida, alternativa sostenible de construcción
Authors: Roux Gutiérrez Rubén Salvador , Espuna Mujica José Adán 
Published: July 2016

En la actualidad, en nuestro país se hace mención a que existen una serie de problemas con los programas de vivienda, aún cuando se ha reducido el déficit de vivienda o que se han construido cada año más viviendas en beneficio de las personas de bajos ingresos. Topelson (2011) el presente artículo describe un estudio sobre una alternativa sustentable de edificación y a la vez pretende demostrar las ventajas del uso del hidróxido de cal y los bloques de tierra comprimida (BTC), para la edificación de vivienda y así poder reducir las emisones de CO2 emitidas por los procesos constructivos convencionalesEl presente artículo trata dos materiales elementales en los procesos constructivos de las viviendas, por un lado se realizá el estudio químico de los morteros cal – arena que se utilizán para el pegado de los mampuestos y los revoques, con la finalidad de determinar la absorción de CO2 y por otra parte se hace el estudio mecánicos de un material alternativo para el uso de muros de carga como son los Bloques de Tierra Comprimida estabilizados con cal, por último se hace un comparativo entre estos materiales alternativos y los convencionales con relación a las emisones de CO2.
Vinculación social de los prestadores de servicio social de odontología de la UAGRO en Guerrero
Authors: Beltrán Cuevas José , Quintero Romero Dulce María , González González Justiniano 
Published: July 2016

Los padecimientos y el deterioro bucodental incrementan su presencia entre la población a todos los ámbitos: local, regional y nacional, con mayores afecciones en los más pobres, por lo que se han articulado esfuerzos entre instituciones educativas y del Sector Salud a fin de llevar a cabo estrategias, planes y programas enfocados a la salud bucodental. Uno de ellos ha sido el programa de Servicio Social al término de la formación académica de los profesionales de la odontología como cierre de su etapa formadora. Sin embargo esta práctica profesional, requisito indispensable para su proceso de titulación, es sin duda un proceso que permite a los pasantes el enfrentarse a la realidad odontológica a fin de comprobar si se encuentran listos para el buen desempeño profesional de la odontología.Método: Desde esta perspectiva se realizó un seguimiento a los pasantes de la Escuela Superior de Odontología de Guerrero, de la generación 2005-2010 a quienes se les aplicaron encuestas y se les incorporó a un foro de discusión junto con otros implicados en su formación profesional a fin de discutir realmente la vinculación social de los profesionistas y su problemática, para analizar la pertinencia del Servicio Social en la atención de los problemas de salud de los habitantes en zonas alejadas y la posibilidad de que a partir de la experiencia, los odontólogos consideren la posibilidad de ejercer profesionalmente en los ámbitos rurales.Resultados: Se encontró que en un principio los pasantes del Servicio Social mostraban una buena disposición para desarrollar sus prácticas profesionales en las comunidades apartadas, lo cual varió al término de su servicio debido a una serie de irregularidades que se presentaron durante el mismo con las que se redujo significativamente el interés de estos profesionistas por laborar profesionalmente fuera de las ciudades.Conclusión: Los resultados muestran la necesidad de revisar la formación y orientación de los profesionales de la odontología de la UAGro, pero sobre todo el que la universidad discuta y acuerde con las instituciones del Sector Salud de los ámbitos nacional, estatal y municipal la articulación de un programa efectivo para la atención de los problemas de salud bucodental en comunidades marginadas.
Photocatalytic Degradation of NOM for Power Plant Feedwater using Coating and Suspension of TiO2
Authors: Emam Eman A. 
Published: July 2016

ABSTRACT: This study investigated the effectiveness of coating and suspension of Degussa P25 TiO2 photocatalyst to remove natural organic matter (NOM) from surface water for use as power plant feedwater. The catalyst yield, transmittance intensity and X‐ray pattern as a function of the number of coatings were characterized. In addition, P25 coating photocatalytic activity was studied. The photocatalytic activity also of P25 suspension with different catalyst concentrations and the reusing of the catalyst without and with regeneration was investigated. Results obtained show that the P25 coatings were transparent with good adhesion to the glass substrate. P25 suspension was found to be more effective in the NOM photodegradation and gave a higher rate constant compared to P25 coating. The maximum rate constants were 0.028 and 0.015 min−1 at 0.7 g/L P25 suspension and 4 coatings, respectively. After four runs without regeneration and three runs with regeneration of P25 reusing, the photoactivity to remove NOM was still significant.
Spatial Variability of Anaerobic Processes and Wastewater pH in Force Mains
Authors: Rudelle Elice Alice , Nielsen Asbjørn Haaning , Hvitved‐Jacobsen Thorkild , Jensen Henriette Stokbro , Vollertsen Jes 
Published: July 2016

ABSTRACT: The present study focuses on anaerobic organic matter transformation processes in force mains for the purpose of improving existing sewer process models. Wastewater samples were obtained at 100 m intervals from a 1 km long pilot scale force main and measured for several wastewater parameters. Transformation rates for selected parameters were calculated and their spatial variability analyzed. In terms of electron transfer, fermentation was the most significant process, resulting in a net volatile fatty acid formation of 0.83 mmol/L. Sulfate reduction resulted in a production of 0.73 mmol/L of inorganic sulfide. Methanogenesis was negligable in all experiments despite an anaerobic residence time of more than 30 hours. As a result of the anaerobic processes, the wastewater pH decreased by approximately one pH unit, resulting in a corresponding increase in the fraction of molecular hydrogen sulfide. A significant spatial variablilty was observed for the average transformation rates of all parameters.
„Vásárolj hazait(ól)”?!
Authors: Láng Edina , Láng László 
Published: July 2016

A cikk egy 2011 nyarán elvégeztetett, reprezentatív kérdőíves felmérés (N=619) eredményein alapul. A megkérdezés célja azoknak az érzelmi és normatív attitűdöknek az azonosítása volt, amelyek befolyásolhatják a hazai élelmiszer- és napifogyasztásicikk-kiskereskedelem vásárlóit a hazai kontra külföldi üzletek, üzletláncok választását érintő döntéseikben. Erős, szignifikáns összefüggést mutattunk ki a gazdasági nacionalizmusnak elkeresztelt attitűd és a hazai üzletek preferenciája között, általában is, és különösen az üzletek hazai/külföldi háttere közötti különbségtételre hajlamos és képes vásárlók körében. Nem találtunk említésre méltó kapcsolatot más vásárlói ideológiák (nacionalizmus, patriotizmus, kozmopolitizmus vagy éppen a „tiszta” fogyasztói etnocentrizmus) és a hazai üzletek előnyben részesítése között. A gazdasági nacionalizmus faktora viszont kölcsönhatásba lép a kognitív, az észlelt üzletjellemzőkre épülő, hazai kontra külföldi láncokkal kapcsolatos preferenciaképzéssel, és javítja a csak az utóbbiakra mint független változókra épített regressziós modell magyarázó erejét.
Journal of Economic Literature (JEL) kód: M31, Z13, M39
A Miskolci Operafesztivál gazdasági és társadalmi-kulturális hatásainak elemző bemutatása
Authors: Kundi Viktória 
Published: July 2016

Jelen tanulmány a Miskolci Operafesztivál gazdasági és társadalmi-kulturális hatásait vizsgálja, bemutatva, hogy egy stagnáló gazdasági helyzetben lévő, nagyipari múlttal rendelkező városban miként képes prosperálni egy kulturális attrakció, amely a tudatos, kulturális alapú városfejlesztés eredményeképpen jöttlétre. A módszertani felvezetést követően, rövid elméleti felvezető után, Miskolc turisztikai adottságainak elemző bemutatása olvasható. A tanulmány további részben a módszertani fejezetben ismertetett módon lebonyolított empirikus vizsgálatok eredményeit láthatjuk.
Journal of Economic Literature (JEL) kód: Z130
Cough Syrup Psychosis
Authors: Amaladoss Alfred , O'Brien Simon 
Published: July 2016

ABSTRACTOver-the-counter medications are widely accessible and used. Cough suppressant syrups contain dextromethorphan (DM), which has the potential to be abused, with resultant psychiatric symptoms. This case report describes a young woman presenting with psychotic mania secondary to DM abuse. We also describe the treatment of this toxidrome and include the results of a literature search on this topic. The recognition of cough syrup as an agent of abuse and its toxidrome is important. This will facilitate early diagnostic clarification and promote efficient treatment strategies.
Effect of time to electrocardiogram on time from electrocardiogram to fibrinolysis in acute myocardial infarction patients
Authors: Atzema Clare L. , Austin Peter C. , Tu Jack V. , Schull Michael J. 
Published: July 2016

ABSTRACTObjective:The American Heart Association (AHA) recommends a benchmark door-to-electrocardiogram (ECG) time of 10 minutes for acute myocardial infarction patients, but this is based on expert opinion (level of evidence C). We sought to establish an evidence-based benchmark door-to-ECG time.Methods:This retrospective cohort study used a population-based sample of patients who suffered an ST elevation myocardial infarction (STEMI) in Ontario between 1999 and 2001. Using cubic smoothing splines, we described (1) the relationship between door-to-ECG time and ECG-to-needle time and (2) the proportion of STEMI patients who met the benchmark door-to-needle time of 30 minutes based on their door-to-ECG time. We hypothesized nonlinear relationships and sought to identify an inflection point in the latter curve that would define the most efficient (benefit the greatest number of patients) door-to-ECG time.Results:In 2,961 STEMI patients, the median door-to-ECG and ECG-to-needle times were 8.0 and 27.0 minutes, respectively. There was a linear increase in ECG-to-needle time as the door-to-ECG time increased, up to approximately 30 minutes, after which the ECG-to-needle time remained constant at 53 minutes. The inflection point in the probability of achieving the benchmark door-to-needle time occurred at 4 minutes, after which it decreased linearly, with every minute of door-to-ECG time decreasing the average probability of achievement by 2.2%.Conclusions:Hospitals that are not meeting benchmark reperfusion times may improve performance by decreasing door-to-ECG times, even if they are meeting the current AHA benchmark door-to-ECG time. The highest probability of meeting the reperfusion target time for fibrinolytic administration is associated with a door-to-ECG time of 4 minutes or less.
Application of Lean principles to improve early cardiac care in the emergency department
Authors: Piggott Zoë , Weldon Erin , Strome Trevor , Chochinov Alecs 
Published: July 2016

ABSTRACTObjective:To achieve our goal of excellent emergency cardiac care, our institution embarked on a Lean process improvement initiative. We sought to examine and quantify the outcome of this project on the care of suspected acute coronary syndrome (ACS) patients in our emergency department (ED).Methods:Front-line ED staff participated in several rapid improvement events, using Lean principles and techniques such as waste elimination, supply chain streamlining, and standard work to increase the value of the early care provided to patients with suspected ACS. A chart review was also conducted. To evaluate our success, proportions of care milestones (first electrocardiogram [ECG], ECG interpretation, physician assessment, and acetylsalicylic acid [ASA] administration) meeting target times were chosen as outcome metrics in this before-and-after study.Results:The proportion of cases with 12-lead ECGs completed within 10 minutes of patient triage increased by 37.4% (p&lt; 0.0001). The proportion of cases with physician assessment initiated within 60 minutes increased by 12.1% (p= 0.0251). Times to ECG, physician assessment, and ASA administration also continued to improve significantly over time (pvalues &lt; 0.0001). Post-Lean, the median time from ECG performance to physician interpretation was 3 minutes. All of these improvements were achieved using existing staff and resources.Conclusions:The application of Lean principles can significantly improve attainment of early diagnostic and therapeutic milestones of emergency cardiac care in the ED.
Surfer's myelopathy: case report and review
Authors: Karabegovic Amna , Strachan-Jackman Shirley , Carr David 
Published: July 2016

ABSTRACTNontraumatic spinal cord injury from surfing is a new entity first described in 2004 and likely of ischemic etiology. We report the case of a 25-year-old man who presented to the emergency department with a 2-week history of lower extremity weakness after surfing in Indonesia. The patient reported developing low back pain, lower extremity weakness, sensory changes, and urinary retention shortly after his first surfing lesson. The patient was subsequently diagnosed with surfer's myelopathy. The purpose of this report is to review the clinical presentation, etiology, risk factors, and management of this increasingly described entity.
Massive levothyroxine ingestion in a pediatric patient: case report and discussion
Authors: Ho Josephine , Jackson Renee , Johnson David 
Published: July 2016

ABSTRACTWe describe the course of a toddler who ingested a massive amount of levothyroxine and review treatment options for such overdoses. A 2½-year-old boy presented shortly after an ingestion of up to 7.6 mg of levothyroxine (potentially as much as 700 µg/kg). He was initially asymptomatic, treated with oral charcoal 1 g/kg, and discharged home from the emergency department after a few hours. He returned approximately 24 hours later with a temperature of 38.5°C, heart rate of 163 beats per minute, respiratory rate of 30 breaths per minute, and blood pressure of 136/70 mm Hg. He had a slightly decreased appetite and no signs or symptoms of infection. He was admitted to hospital and treated with oral acetaminophen. The initial free thyroxine (T4) was &gt; 100 pmol/L and free triiodothyronine (T3) was 35.3 pmol/L. The patient had desquamation of the palms and soles, hair loss, and irritability during the month following the ingestion. Resolution of the elevated free T4occurred by 12 days post-ingestion and normalization of the thyroid-stimulating hormone by 7 weeks post-ingestion. There were no longterm sequelae. Levothyroxine overdose can result in significant complications, including seizures and arrhythmias, both of which should be monitored for. However, as our case illustrates, massive ingestion of levothyroxine in children typically follows a benign course.
Carbon monoxide poisoning in narghile (water pipe) tobacco smokers
Authors: Fauci Giovanna La , Weiser Giora , Steiner Ivan P. , Shavit Itai 
Published: July 2016

ABSTRACT
Narghile (water pipe, hookah, shisha, goza, hubble bubble, argeela) is a traditional method of tobacco use. In recent years, its use has increased worldwide, especially among young people. Narghile smoking, compared to cigarette smoking, can result in more smoke exposure and greater levels of carbon monoxide (CO). We present an acutely confused adolescent patient who had CO poisoning after narghile tobacco smoking. She presented with syncope and a carboxyhemoglobin level of 24% and was treated with hyperbaric oxygen. Five additional cases of CO poisoning after narghile smoking were identified during a literature search, with carboxyhemoglobin levels of 20 to 30%. Each patient was treated with oxygen supplementation and did well clinically. In light of the increasing popularity of narghile smoking, young patients presenting with unexplained confusion or nonspecific neurologic symptoms should be asked specifically about this exposure, followed by carboxyhemoglobin measurement.