bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation and monitoring of transdisciplinary collaborations
Authors: van Drooge Leonie , Spaapen Jack 
Published: July 2017

AbstractIn this paper we focus on the governance, in particular evaluation and monitoring, of the growing number of transdisciplinary collaborations (TDC’s). Researchers and a variety of stakeholders collaborate in such TDC’s, the purpose of which is to address societal challenges, like renewable energy, healthy aging or better language teaching in schools. Commonly used practices for evaluation of scientific research (accountability, rankings and benchmarking, dedicated to scientific excellence) do not fit the goals of TDC’s. A bottom up or stakeholder oriented approach is better suited; one that stimulates mutual learning as well as the development of socially robust knowledge. We introduce the participatory impact pathways analysis (PIPA), as a method that suits the requirements. It has been developed in the context of development research. Two crucial features are the involvement of stakeholders from the start, and the joint development of a theory of change. This narrates what one wants to achieve and how that will be achieved. From this, stakeholders construct a logical frame that serves as a source for indicators. These indicators enable monitoring ex durante, during the TDC. We present evidence of the use of PIPA for a TDC. From this empirical evidence a number of issues with regard to evaluation, monitoring and indicators can be identified that require attention. Most prominent is the change of function of indicators. Instead of looking back and a focus on past performance, indicators look forward, in the short, intermediate and more distant future.
Expending Role of Microsatellite Instability in Diagnosis and Treatment of Colorectal Cancers
Authors: Chang Liisa , Chang Minna , Chang Hanna M. , Chang Fuju 
Published: July 2017

Abstract
Background
Colorectal carcinomas with high-frequency microsatellite instability (MSI-H) account for 15% of all colorectal cancers, including 12% of sporadic cases and 3% of cancers associated with Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer syndrome, HNPCC). Lynch syndrome is an autosomal dominant hereditary cancer syndrome, caused by germline mutations in mismatch repair genes, including MLH1, MSH2, MSH6 and PMS2.

Methods
Published articles from peer-reviewed journals were obtained from PubMed, Google Scholar and Clinicaltrials.gov. Based on the recent research data, we provide an update on the MSI testing, along with the evolving role of MSI in diagnosis, prognosis and treatment of colorectal cancers.

Results
Studies have led to significant advances in the molecular pathogenesis and clinicopathological characteristics of MSI-H colorectal cancers. Emerging evidence suggests that colorectal cancers with MSI-H show different outcome and treatment response from those with microsatellite stable (MSS) tumors. Therefore, MSI testing is essential not only in the genetic context, but it may also have important prognostic and predictive value of response to chemotherapy and immunotherapy.

Conclusions
Many experts and professional authorities have recommended a universal MSI testing in all individuals newly diagnosed with colorectal cancers.
Fertility Intentions and Residential Relocations
Authors: Vidal Sergi , Huinink Johannes , Feldhaus Michael 
Published: July 2017

Abstract
This research addresses the question of whether fertility intentions (before conception) are associated with residential relocations and the distance of the relocation. We empirically tested this using data from two birth cohorts (aged 24–28 and 34–38 in the first survey wave) of the German Family Panel (pairfam) and event history analysis. Bivariate analyses showed that coupled individuals relocated at a higher rate if they intended to have a(nother) child. We found substantial heterogeneity according to individuals’ age and parental status, particularly for outside-town relocations. Childless individuals of average age at family formation—a highly mobile group—relocated at a lower rate if they intended to have a child. In contrast, older individuals who already had children—the least-mobile group—relocated at a higher rate if they intended to have another child. Multivariate analyses show that these associations are largely due to adjustments in housing and other living conditions. Our results suggest that anticipatory relocations (before conception) to adapt to growing household size are importantly nuanced by the opportunities and rationales of couples to adjust their living conditions over the life course. Our research contributes to the understanding of residential mobility as a by-product of fertility decisions and, more broadly, evidences that intentions matter and need to be considered in the analysis of family life courses.
Devolution of Powers in Sarawak: A Dynamic Process of Redesigning Territorial Governance in a Federal System
Authors: HARDING Andrew 
Published: July 2017

AbstractThis article is based on a case study of the developing process of devolution of powers in Sarawak as an aspect of the operation of cooperative federalism in Malaysia. The argument developed is that devolution can be seen and used in conjunction with and in reinforcement of federalism, rather than being simply an alternative method of decentralizing powers. The study finds that this approach may be more promising than a more confrontational approach based on arguments around the fulfilment of the original federal bargain, and is also potentially more open-ended and creative (a process rather than an event), embracing issues within the federal bargain but also issues that are not dealt with in that bargain. The study is based on a unique opportunity to canvass the views of Sarawak leaders at the iteration of the devolution process.
Loss of cane and sugar yield resulting from Ceratovacuna lanigera Zehntner damage in cane-growing regions in China
Authors: Li W.F. , Zhang R.Y. , Huang Y.K. , Pu C.H. , Yin J. , Cang X.Y. , Shan H.L. , Wang X.Y. , Luo Z.M. 
Published: July 2017

AbstractCeratovacuna lanigera Zehntner is a major leaf pest of sugarcane. Widely distributed, it affects both the yield and quality of sugarcane in China. This study aimed to assess real yield and sugar yield losses, and the effect of C. lanigera damage on emergence of newly planted and ratoon cane under current production levels. Field experiments were carried out from 2014 to 2016 in Yunnan Province China. At maturity, plants were harvested and weighed to determine yield, and the effect on sugarcane quality and sucrose content analyzed. Real yield decreased by average of 46,185 kg hm−2 (range: 37,545–61,845 kg hm−2) in damaged versus undamaged areas, with an average yield loss rate of 35.9% (28.5–45.7%). Juice yield decreased by an average of 3.01% (2.4–4.13%) and sucrose content by 6.38% (5.48–8.16%). Juice brix decreased by an average of 7.66°BX (6.95–9.05°BX) and juice gravity purity by 12.35% (8.43–19.97%). In contrast, the reducing sugar content increased by an average of 1.21% (1.01–1.3%). Emergence rates of newly planted cane decreased by an average of 26.0% (24.7–27.3%). The emergence number of ratoon cane decreased by 66,834 hm2 (57,429–76,238 hm−2) and relative emergence loss rates of ratoon cane decreased by an average of 57.8% (57.6–58.0%). These findings confirm that C. lanigera damage severely affects sugarcane yield and quality in Yunnan Province. The results will help the implementation of effective control measures, thereby supporting sustainable development of the Chinese sugar industry.
Morphological and molecular characterization ofTarantobelus arachnicidagen. n., sp. n. (Nematoda, Rhabditida, Brevibuccidae), a parasitic nematode of tarantulas
Authors: Abolafia J. , Peña-Santiago R. 
Published: July 2017

AbstractA new genus and new species,Tarantobelus arachnicida, was found in the oral opening of tarantula spiders bred in captivity in Poland. The new species is characterized by having a small body (0.77–0.95 mm long in females and 0.66–0.84 mm in males), cuticle poorly annulated by transverse incisures, lateral field inconspicuous, lips separated with small cuticular flaps topping each lip, stoma panagrolaimoid with gymnostom well developed with robust and refringent rhabdia, pharynx panagrolaimoid with isthmus slightly longer than the basal bulb, intestine with cardiac (anterior) and rectal (posterior) areas with narrower walls. Mature females with intestinal cells including needle crystal packs, excretory pore at isthmus level, female reproductive system panagrolaimoid with post-vulval sac 0.4–0.8 times the length of the corresponding body diameter and having very thick walls, vulva very prominent, female rectum 0.8–1.3 times the length of the anal body diameter, female tail conical with acute tip with phasmids at 58–62% of its length. Male tail conical with long and thin mucro, spicules ventrad bent having rounded manubrium and thick gubernaculum. Description, measurements and illustrations of the new species are provided. Molecular analyses show its relationship withBrevibuccaandCuticonema. On the other hand,Medibullaand its corresponding subfamily Medibullinae, previously in Osstellidae, are transferred to Panagrolaimidae, being Shahnematinae, the junior synonym of Medibullinae.Indocephalobus, recently proposed and located in the family Panagrolaimidae, is considered a junior synonym ofDiplogastrellus(Diplogasteromorpha), and its only species,I. zebrae, is considered a junior synonym ofD. gracilis. In addition, a key to identification of panagrolaimoid genera is included.
Shifts in habitat suitability and the conservation status of the Endangered Andean cat Leopardus jacobita under climate change scenarios
Authors: Bennett Magdalena , Marquet Pablo A. , Sillero-Zubiri Claudio , Marino Jorgelina 
Published: July 2017

AbstractOrganisms adapted to life at high elevations are particularly threatened by climate change, which can cause them to become isolated on mountain tops, yet their responses may vary according to their position in the food chain and their ecological flexibility. Predicting the future distributions of such organisms requires fine-tuned species-specific models. Building on a previous ecological niche model, we explored shifts in the suitability of habitats for the Endangered Andean cat Leopardus jacobita, and assessed how these will be represented within existing protected areas in the future. Using a robust set of presence records and corrected climate surfaces, we applied the Maxent algorithm to model habitat suitability for this carnivore and for its preferred prey, the mountain viscacha Lagidium viscacia. Our predictions indicate that the areas climatically suitable for Andean cats could contract by up to 30% by 2080 under the most pessimistic scenario, with an overall upwards shift of 225 m and a polewards displacement of 98–180 km. The predicted range contraction was more pronounced in the species’ core range, in the Bolivian and Peruvian Andes, whereas suitable conditions may increase in the southern range in Patagonia. Bolivia and Peru are predicted to suffer the most marked decline in habitat representativeness within protected areas. The southern range appears to be less vulnerable to climate change, offering opportunities for the conservation of this genetically distinct population. We discuss the value and limitations of using species distribution modelling to assess changes in the potential distribution and conservation status of this and other Andean species.
Eocene ungulate mammals from West Antarctica: implications from their fossil record and a new species
Authors: Gelfo Javier N. , López Guillermo M. , Santillana Sergio N. 
Published: July 2017

AbstractHere we describe a new terrestrial mammal from the Eocene of Seymour Island (Isla Marambio) represented by a lower left third molar and assigned to a new species of Sparnotheriodontidae, an ungulate family with a broad palaeobiogeographical distribution in South America. The specimen was found in the Cucullaea I allomember of the La Meseta Formation, in a new mammalian locality (IAA 2/16).Notiolofos regueroisp. nov. shares a brachyodont, lophoselenodont and bicrescentic molar pattern withN. arquinotiensis, recorded for a stratigraphic sequence of 17.5 Ma in Antarctica. The criteria for the species differentiation are the absence of mesial and labial cingulids, the larger paraconid, the wider talonid basin, the accentuated distal projection of the hypoconulid, the centroconid development and the smaller size. Together with the astrapotherianAntarctodon sobrali, they represent the medium to large terrestrial mammals of the early Eocene Antarctic landscape that was mostly dominated by closed forests ofNothofagus. Dental wear facets and differences in their body mass are inferred and discussed as possible evidence of niche differentiation. Additionally, the presence of land mammals with Patagonian affinities in the Eocene of Antarctica reinforces the Cretaceous–Palaeocene presence of the Weddellian Isthmus, a functional land corridor between Antarctica and South America.
Professional caregivers' experiences with the Liverpool Care Pathway in dementia: An ethnographic study in a Dutch nursing home
Authors: Lemos Dekker Natashe , Gysels Marjolein , van der Steen Jenny T. 
Published: July 2017

ABSTRACTObjective:There are few studies on how professional caregivers apply the Liverpool Care Pathway (LCP) in nursing home care for people with dementia. Further, despite critiques in the United Kingdom, the LCP continues to be used in the Netherlands, while, to the best of our knowledge, no studies have been conducted since its implementation. The purpose of the present study was to analyze professional caregivers' experiences with the LCP in this context.Method:This article draws on an ethnographic study. Data collection was based on 4 months of ethnographic fieldwork in 2015 in 11 psychogeriatric units of a nursing home in a rural area of the Netherlands. Data collection included participant observation and 25 semistructured audiotaped interviews with specialist elderly care physicians, nursing staff, and a nurse practitioner.Results:We found that professional caregivers appreciate the LCP as a communication tool and as a reminder of care goals. However, the document was deemed too complicated and to cause duplication of work. It was also reported that the LCP did not cover the complexity of care needs that emerge in practice. Actual care needs were prioritized over the LCP, which calls its contribution into question.Significance of Results:Overall, the LCP does not match the context of dementia care in the nursing home. While it could be argued that the LCP does not intend to replace good care, its benefits as a reminder and a communication tool need continued consideration in relation to the amount of work it requires as a bureaucratic obligation.
Phenotypic and genotypic richness of denitrifiers revealed by a novel isolation strategy
Authors: Lycus Pawel , Lovise Bøthun Kari , Bergaust Linda , Peele Shapleigh James , Reier Bakken Lars , Frostegård Åsa 
Published: July 2017

Abstract
Present-day knowledge on the regulatory biology of denitrification is based on studies of selected model organisms. These show large variations in their potential contribution to NO2−, NO, and N2O accumulation, attributed to lack of genes coding for denitrification reductases, but also to variations in their transcriptional regulation, as well as to post-transcriptional phenomena. To validate the relevance of these observations, there is a need to study a wider range of denitrifiers. We designed an isolation protocol that identifies all possible combinations of truncated denitrification chains (NO3−/NO2−/NO/N2O/N2). Of 176 isolates from two soils (pH 3.7 and 7.4), 30 were denitrifiers sensu stricto, reducing NO2− to gas, and five capable of N2O reduction only. Altogether, 70 isolates performed at least one reduction step, including two DNRA isolates. Gas kinetics and electron flow calculations revealed that several features with potential impact on N2O production, reported from model organisms, also exist in these novel isolates, including denitrification bet-hedging and control of NO2−/NO/N2O accumulation. Whole genome sequencing confirmed most truncations but also showed that phenotypes cannot be predicted solely from genetic potential. Interestingly, and opposed to the commonly observed inability to reduce N2O under acidic conditions, one isolate identified as Rhodanobacter reduced N2O only at low pH.
Escherichia coli FtsA forms lipid-bound minirings that antagonize lateral interactions between FtsZ protofilaments
Authors: Krupka Marcin , Rowlett Veronica W. , Morado Dustin , Vitrac Heidi , Schoenemann Kara , Liu Jun , Margolin William 
Published: July 2017

AbstractMost bacteria divide using a protein machine called the divisome that spans the cytoplasmic membrane. Key divisome proteins on the membrane’s cytoplasmic side include tubulin-like FtsZ, which forms GTP-dependent protofilaments, and actin-like FtsA, which tethers FtsZ to the membrane. Here we present genetic evidence that in Escherichia coli, FtsA antagonizes FtsZ protofilament bundling in vivo. We then show that purified FtsA does not form straight polymers on lipid monolayers as expected, but instead assembles into dodecameric minirings, often in hexameric arrays. When coassembled with FtsZ on lipid monolayers, these FtsA minirings appear to guide FtsZ to form long, often parallel, but unbundled protofilaments, whereas a mutant of FtsZ (FtsZ*) with stronger lateral interactions remains bundled. In contrast, a hypermorphic mutant of FtsA (FtsA*) forms mainly arcs instead of minirings and enhances lateral interactions between FtsZ protofilaments. Based on these results, we propose that FtsA antagonizes lateral interactions between FtsZ protofilaments, and that the oligomeric state of FtsA may influence FtsZ higher-order structure and divisome function.
Association between allergic conditions and colorectal cancer risk/mortality: a meta-analysis of prospective studies
Authors: Ma Wangqian , Yang Jia , Li Peiwei , Lu Xinliang , Cai Jianting 
Published: July 2017

AbstractWe aimed to assess the association between allergic conditions and risk/mortality of colorectal cancer (CRC). A systematic literature search was conducted using Pubmed and Embase to identify relevant studies. Prospective studies assessing the association between allergic conditions and risk/mortality of CRC were included. Risk ratios (RRs) were pooled with either a fixed- or a random-effects model according to heterogeneity. A total of 515379 participants and 10345 CRC cases from 12 studies were included in the analysis of CRC risk, while four studies with 1484741 individuals and 30040 CRC deaths were included in the analysis of CRC mortality. The pooled RR for the association between allergic conditions and CRC risk was 0.88 (95% CI 0.83–0.92). The inverse association was observed both in colon cancer (pooled RR = 0.83, 95% CI 0.72–0.97) and rectal cancer (pooled RR = 0.83, 95% CI 0.74–0.93). Moreover, no gender difference was observed in the analysis of CRC risk (for males, pooled RR = 0.88, 95% CI 0.81–0.96; for females, pooled RR = 0.88, 95% CI 0.82–0.95). And allergic conditions were also found to be inversely associated with CRC mortality (pooled RR = 0.88, 95% CI 0.83–0.92). In conclusion, the current meta-analysis provides further evidence that allergic conditions were inversely associated with CRC risk and mortality.
Negative velocity fluctuations and non-equilibrium fluctuation relation for a driven high critical current vortex state
Authors: Bag Biplab , Shaw Gorky , Banerjee S. S. , Majumdar Sayantan , Sood A. K. , Grover A. K. 
Published: July 2017

AbstractUnder the influence of a constant drive the moving vortex state in 2H-NbS2 superconductor exhibits a negative differential resistance (NDR) transition from a steady flow to an immobile state. This state possesses a high depinning current threshold ($${{\boldsymbol{I}}}_{{\boldsymbol{c}}}^{{\boldsymbol{h}}}$$

I

c

h

) with unconventional depinning characteristics. At currents well above $${{\boldsymbol{I}}}_{{\boldsymbol{c}}}^{{\boldsymbol{h}}}$$

I

c

h

, the moving vortex state exhibits a multimodal velocity distribution which is characteristic of vortex flow instabilities in the NDR regime. However at lower currents which are just above $${{\boldsymbol{I}}}_{{\boldsymbol{c}}}^{{\boldsymbol{h}}}$$

I

c

h

, the velocity distribution is non-Gaussian with a tail extending to significant negative velocity values. These unusual negative velocity events correspond to vortices drifting opposite to the driving force direction. We show that this distribution obeys the Gallavotti-Cohen Non-Equilibrium Fluctuation Relation (GC-NEFR). Just above $${{\boldsymbol{I}}}_{{\boldsymbol{c}}}^{{\boldsymbol{h}}}$$

I

c

h

, we also find a high vortex density fluctuating driven state not obeying the conventional GC-NEFR. The GC-NEFR analysis provides a measure of an effective energy scale (E
eff
) associated with the driven vortex state. The E
eff
corresponds to the average energy dissipated by the fluctuating vortex state above $${{\boldsymbol{I}}}_{{\boldsymbol{c}}}^{{\boldsymbol{h}}}$$

I

c

h

. We propose the high E
eff
value corresponds to the onset of high energy dynamic instabilities in this driven vortex state just above $${{\boldsymbol{I}}}_{{\boldsymbol{c}}}^{{\boldsymbol{h}}}$$

I

c

h

.
3D printed scaffolds of calcium silicate-doped β-TCP synergize with co-cultured endothelial and stromal cells to promote vascularization and bone formation
Authors: Deng Yuan , Jiang Chuan , Li Cuidi , Li Tao , Peng Mingzheng , Wang Jinwu , Dai Kerong 
Published: July 2017

AbstractSynthetic bone scaffolds have potential application in repairing large bone defects, however, inefficient vascularization after implantation remains the major issue of graft failure. Herein, porous β-tricalcium phosphate (β-TCP) scaffolds with calcium silicate (CS) were 3D printed, and pre-seeded with co-cultured human umbilical cord vein endothelial cells (HUVECs) and human bone marrow stromal cells (hBMSCs) to construct tissue engineering scaffolds with accelerated vascularization and better bone formation. Results showed that in vitro β-TCP scaffolds doped with 5% CS (5%CS/β-TCP) were biocompatible, and stimulated angiogenesis and osteogenesis. The results also showed that 5%CS/β-TCP scaffolds not only stimulated co-cultured cells angiogenesis on Matrigel, but also stimulated co-cultured cells to form microcapillary-like structures on scaffolds, and promoted migration of BMSCs by stimulating co-cultured cells to secrete PDGF-BB and CXCL12 into the surrounding environment. Moreover, 5%CS/β-TCP scaffolds enhanced vascularization and osteoinduction in comparison with β-TCP, and synergized with co-cultured cells to further increase early vessel formation, which was accompanied by earlier and better ectopic bone formation when implanted subcutaneously in nude mice. Thus, our findings suggest that porous 5%CS/β-TCP scaffolds seeded with co-cultured cells provide new strategy for accelerating tissue engineering scaffolds vascularization and osteogenesis, and show potential as treatment for large bone defects.