bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterogeneous E‐Textiles: Materials, Manufacturing and Sustainability
Authors: Beeby Stephen P. , Torah Russel N. , Wagih Mahmoud , Isaia Beckie , Black Sandy , Saunders Jessica , Yang Kai 
Published: September 2024

AbstractElectronic textiles (e‐textiles) combine electronic functions (e.g., sensing, actuating, data processing) with textiles. E‐textiles are a platform technology with the potential for ubiquitous deployment in any application scenario where textiles can be found. E‐textiles have attracted significant research interests from materials and manufacturing process development to applications such as sports/fitness, healthcare, and workwear. While significant advances have been made in the research domain regarding the integration of electronic functionality, the technology is relatively immature and significant challenges remain in the manufacturing of commercialized e‐textile systems. This paper reviews the state of the art in e‐textile manufacturing including materials (e.g., yarns, inks), fabrication (e.g., weaving, knitting, printing), electronic integration and interconnections. This paper also reviews the key principles of textile sustainability and electronic waste (e‐wastemanagement, which provide useful guidance on e‐textile design and manufacturing to minimize their impact on the environment. Examples are given to demonstrate the early work toward sustainable e‐textiles. The remaining research challenges regarding scalable and sustainable manufacturing of e‐textiles are presented.
Advancing Programmable Information Encryption Circuits Through Colorful Phosphorescent Carbon Nanodots with Versatile Lifetimes
Authors: Jiang Li‐Ying , Zhang Si‐Fan , Liang Ya‐Chuan , Zhou Yu‐Chen , Shao Hao‐Chun , Wang Hai‐Yan , Liu Kai‐Kai , Shan Chong‐Xin 
Published: September 2024

AbstractOptical encryption technology attracts considerable attention in the field of information encryption, information storage, and anti‐counterfeiting. However, optical encryption based on conventional on/off mode still faces issues such as low scalability, ease of cracking, and poor storage capacity; multi‐dimensional and high storage capacity information encryption systems are thus needed. Herein, a programmable information encryption circuit system is demonstrated by constructing a delay light‐emitting diode (LED) array using multi‐color phosphorescent carbon nanodots (CNDs) with versatile lifetimes. The CNDs show adjustable luminescence wavelength and lifetime from 192 to 1148 ms. The programmable delay luminescent circuit provides an intricate framework for meticulously integrating an LED array, enabling the creation of intricate patterns or alphanumeric codes. These intricate designs are engineered to serve as a component of an encryption system, which can be deciphered and unveiled under a specific delay time range. This study demonstrates the feasibility and superiority of the system as a new type of information anti‐counterfeiting encryption technology, providing a new concept for exploring the field of integrated circuit anti‐counterfeiting and encryption.
Dynamic Brain Lipid Profiles Modulate Microglial Lipid Droplet Accumulation and Inflammation Under Ischemic Conditions in Mice
Authors: Wei Wei , Lattau Seyed Siyawasch Justus , Xin Wenqiang , Pan Yongli , Tatenhorst Lars , Zhang Lin , Graf Irina , Kuang Yaoyun , Zheng Xuan , Hao Zhongnan , Popa‐Wagner Aurel , Gerner Stefan T. , Huber Sabine , Nietert Manuel , Klose Christian , Kilic Ertugrul , Hermann Dirk M. , Bähr Mathias , Huttner Hagen B. , Liu Hua , Fitzner Dirk , Doeppner Thorsten R. 
Published: September 2024

AbstractMicroglia are critically involved in post‐stroke inflammation affecting neurological outcomes. Lipid droplet (LD) accumulation in microglia results in a dysfunctional and pro‐inflammatory state in the aged brain and worsens the outcome of neuroinflammatory and neurodegenerative diseases. However, the role of LD‐rich microglia (LDRM) under stroke conditions is unknown. Using in vitro and in vivo stroke models, herein accumulation patterns of microglial LD and their corresponding microglial inflammatory signaling cascades are studied. Interactions between temporal and spatial dynamics of lipid profiles and microglial phenotypes in different post‐stroke brain regions are found. Hence, microglia display enhanced levels of LD accumulation and elevated perilipin 2 (PLIN2) expression patterns when exposed to hypoxia or stroke. Such LDRM exhibit high levels of TNF‐α, IL‐6, and IL‐1β as well as a pro‐inflammatory phenotype and differentially expressed lipid metabolism‐related genes. These post‐ischemic alterations result in distinct lipid profiles with spatial and temporal dynamics, especially with regard to cholesteryl ester and triacylglycerol levels, further exacerbating post‐ischemic inflammation. The present study sheds new light on the dynamic changes of brain lipid profiles and aggregation patterns of LD in microglia exposed to ischemia, demonstrating a mutual mechanism between microglial phenotype and function, which contributes to progression of brain injury.
Amino‐Arsine and Amino‐Phosphine Based Synthesis of InAs@InP@ZnSe core@shell@shell Quantum Dots
Authors: Liu Zheming , Llusar Jordi , Karakkal Hiba H. , Zhu Dongxu , Ivanov Yurii P. , Prato Mirko , Divitini Giorgio , Brovelli Sergio , Infante Ivan , De Trizio Luca , Manna Liberato 
Published: September 2024

AbstractA colloidal synthesis protocol is demonstrated for InAs@InP core@shell quantum dots (QDs) with a tunable InP shell thickness (ranging from 3 to 8 monolayers), utilizing tris(diethylamino)‐arsine and ‐phosphine. Structural analysis reveals that the InP shell preferentially grows onto the tetrahedral InAs cores along the <‐1‐1‐1> directions, forming tetrapodal‐shaped InAs@InP QDs. Growth of the InP shell causes a red shift in the absorption spectrum of the QDs. This is explained by considering that electrons are delocalized throughout the whole core@shell QDs, while holes preferentially leak along the <‐1‐1‐1> directions, as indicated by the density functional theory calculations. This means such heterostructures cannot be described as type‐I or quasi type‐II, contrary to earlier assumptions. The overlap of carrier wavefunctions throughout the entire InAs@InP QD structure results in no significant reduction of the Auger recombination rate, which remains as fast as in InAs QDs. However, the InP shell enhances photoluminescence (PL) efficiency (up to ≈13%) by passivating surface trap states of the InAs QDs (mainly located close to the top of the valence band). The overgrowth of a ZnSe shell endows the QDs with a high PL efficiency (≈55%) and good stability upon air exposure (≈80% PL intensity retention after 14 days).
Assessment of data‐driven modeling approaches for chromatographic separation processes
Authors: Michalopoulou Foteini , Papathanasiou Maria M. 
Published: September 2024

AbstractChromatographic separation processes are described by nonlinear partial differential and algebraic equations, which may result in high computational cost, hindering further online applications. To decrease the computational burden, different data‐driven modeling approaches can be implemented. In this work, we investigate different strategies of data‐driven modeling for chromatographic processes, using artificial neural networks to predict pseudo‐dynamic elution profiles, without the use of explicit temporal information. We assess the performance of the surrogates trained on different dataset sizes, achieving good predictions with a minimum of 3400 data points. Different activation functions are used and evaluated against the original high‐fidelity model, using accuracy, interpolation, and simulation time as performance metrics. Based on these metrics, the best performing data‐driven models are implemented in a process optimization framework. The results indicate that data‐driven models can capture the nonlinear profile of the process and that can be considered as reliable surrogates used to aid process development.
Measurement Dependence can Affect Security in a Quantum Network
Authors: Kundu Amit , Sarkar Debasis 
Published: September 2024

AbstractNetwork Nonlocality is an advanced study of quantum nonlocality that comprises network structure beyond Bell's theorem. The development of quantum networks has the potential to bring a lot of technological applications in several quantum information processing tasks. Here, the focus is on how the role of the independence of the measurement choices by the end parties in a network works and can be used to affect the security in a quantum network. In both three‐parties two‐sources bilocal network and four‐parties three‐sources star network scenarios, this study is able to show, a practical way to understand the relaxation of the assumptions to enhance a real security protocol if someone wants to breach in a network communication. Theoretically, it have been proved that by relaxing the independence of the measurement choices of only one end party, a Standard Network Nonlocality (SNN) and more stronger Full Network Nonlocality (FNN) can be created and the maximum quantum violation by the classical no‐signalling local model can be obtained. The distinguish between two types of network nonlocality, SNN and FNN, can also be made. It has been shown that FNN is a stronger correlation than SNN in the sense that the former comes in a scenario where all the sources must be nonlocal in nature.
Amorphous silica nanoparticles exhibit antitumor activity in triple‐negative breast cancer cells
Authors: Ibarra Agustina , Ferronato María Julia , Clemente Valentina , Barrientos Anabel , Alonso Eliana Noelia , Fermento María Eugenia , Coló Georgina Pamela , Facchinetti María Marta , Curino Alejandro Carlos , Agotegaray Mariela 
Published: September 2024

AbstractTriple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is mainly treated with cytotoxic chemotherapy. However, this treatment is not always effective, and an important percentage of patients develop recurrence. Nanomaterials are emerging as alternative treatment options for various diseases, including cancer. This work reports the synthesis, characterization, antitumor activity evaluation, and sub‐acute toxicity studies of two formulations based on amorphous silica nanoparticles (SiNPs). They are functionalized with 3‐aminopropyltriethoxisilane (Si@NH2) and folic acid (FA; Si@FA). The results show that SiNPs reduce the viability and migration of TNBC MDA‐MB‐231 and 4T1 cell lines and Si@FA do not affect the growth of the mammary nonmalignant HC11 cells. In addition, Si@FA induces reactive oxygen species (ROS) generation and displays antiproliferative and subsequently proapoptotic effects in MDA‐MB‐231 cells. Moreover, none of the SiNPs cause signs of sub‐acute toxicity in mice when administered at 30 mg/kg over a month. In conclusion, these nanosystems display intrinsic antitumor activity without causing toxic in vivo effects, being a promising therapeutic alternative for TNBC.
Using Rigidity and Conjugation of Subunits to Modulate Supramolecular Topologies Constructed by Half‐Sandwich Fragments
Authors: Liu Liang‐Chen , Liao Yu‐Luan , Ma Hui‐Rong , Shi Hua‐Tian , Yu Wei‐Bin 
Published: September 2024

AbstractThe synthesis of supramolecular compounds with a high degree of controllability and the targeted modulation of their topological transitions pose significant challenges in situ. In this study, we have successfully constructed an array of discrete structures based on a series of bidentate pyridyl ligands (L1, L2, and L3), which were subsequently ligated with half‐sandwiched (Cp*Ir fragments) building blocks. Our further investigations elucidate a strategy for coordinating the relative lengths of the bidentate ligands with the building blocks, achieving specific concentrations that drive the transformation of tetranuclear metal macrocycles into Borromean rings. Notably, the distinct characteristics of the three pyridyl ligands markedly influence the efficiency of synthesis and the topological conversion of the supramolecular macrocycles. Detailed structural analyses reveal that π‐π stacking interactions, the electron‐donating capabilities of the ligands, and hydrogen‐bonding interactions are pivotal in stabilizing these molecular macrocycles and in facilitating their transformation to Borromean rings. The analyses underscore the importance of the electron‐rich effect induced by the sulfur atoms in the ligands and the regulation and modulation of the pyridine functional group in contributing to the structural stability and altered characteristics of the macrocycles.
Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study
Authors: Tentoni Nicolás , Hwang Miriam , Villanueva Gabriela , Combs Ryan , Lowe Jennifer , Ramsey Laura B. , Taylor Zachary L. , Carrillo Thais Murciano , Aumente María Dolores , López‐Viñau López Teresa , Rizzari Carmelo , Howard Scott C. 
Published: September 2024

AbstractIntroductionHigh‐dose methotrexate (HDMTX) use can be limited by the development of acute kidney injury (AKI). Early AKI detection is paramount to prevent further renal injury and irreversible toxicities. This study sought to determine whether early elimination patterns of MTX would be useful as a biomarker of AKI in HDMTX treatment.MethodsThis retrospective cohort study included two sites that collected ≥2 MTX levels within 16 h from completion of MTX infusion. Early levels were tagged and MTX elimination half‐life (t½) were calculated from combinations of two of three different early time periods. Receiver operating characteristic (ROC) curves were synthesized for each elimination t½ (biomarker) with respect to AKI and delayed methotrexate elimination (DME); the biomarker with the highest area under the ROC curve (AUC) was tested in a multiple variable logistic regression model.ResultsData from 169 patients who received a total of 556 courses of HDMTX were analyzed. ROC analysis revealed MTX elimination t½ calculated from the second and third time periods had the highest AUC for AKI at 0.62 (interquartile range [IQR] 0.56–0.69) and DME at 0.86 (IQR 0.73–1.00). After adjusting for age, sex, dose (mg/m2), infusion duration, HDMTX course, and baseline estimated glomerular filtration rate, it remained significant for AKI with an OR of 1.29 and 95% confidence interval of 1.03–1.65.ConclusionEarly MTX elimination t½ measured within 16 h of infusion completion was significantly associated with the development of AKI and serves as an early clearance biomarker that may identify patients who benefit from increased hydration, augmented leucovorin rescue, and glucarpidase administration.
Lysosomes accumulate at the perinuclear region of muscle cells during chick myogenesis
Authors: Bagri Kayo Moreira , Pereira Miria Gomes , Leichtweis Kamila Souto , Abreu Jose G. , Costa Manoel Luis , Mermelstein Claudia 
Published: September 2024

AbstractLysosomes are involved in a myriad of cellular functions, such as degradation of macromolecules, endocytosis and exocytosis, modulation of several signaling pathways, and regulation of cell metabolism. To fulfill these diverse functions, lysosomes can undergo several dynamic changes in their content, size, pH, and location within cells. Here, we studied some of these parameters during embryonic chick skeletal muscle cells. We used an anti‐lysosome‐associated membrane protein 2 (LAMP2) antibody to specifically determine the intracellular localization of lysosomes in these cells. Our data shows that lysosomes are highly enriched in the perinuclear region of chick embryonic muscle cells. We also showed that the wingless signaling pathway (Wnt)/β‐catenin signaling pathway can modulate the location of LAMP2 in chick myogenic cells. Our results highlight the role of lysosomes during muscle differentiation and particularly the presence of a subcellular population of lysosomes that are concentrated in the perinuclear region of muscle cells.
Case report of tumoral calcinosis in a peritoneal dialysis patient with tertiary hyperparathyroidism and systemic lupus erythematosus
Authors: Jayanatha Kalpa , Idrus Irfan , Sapsford Mark , Tutone Viliami , Lam Michael 
Published: September 2024

Key Clinical MessageTumoral calcinosis (TC) is a rare condition characterized by dystrophic calcinosis. TC in end stage kidney disease is associated with severe hyperparathyroidism. It is radiologically characterized by multilobulated cystic calcifications in periarticular regions without erosive arthropathy or osseus destruction. Secondary TC may necessitate medical or surgical parathyroidectomy for symptom control.
Electrochemical Carboarylation of Activated Alkenes with CO2 and Electron‐deficient Aryl Bromides
Authors: Yang Zhaoliang , Liu Chunlei , Zhong Cheng , Zhang Jianye , Liu Shengzhang , Yu mingming , Li yangyang , Yi Hong , Lei Aiwen 
Published: September 2024

Comprehensive SummaryThe simultaneous construction of two vicinal C—C bonds in a molecule remains a significant challenge. In this work, we disclose an electroreductive carboarylation of activated alkenes under mild, transition metal‐free conditions. Utilizing readily available starting materials (electron‐deficient aryl bromides, activated alkenes, and CO2), this method demonstrates broad substrate scope and good functional group tolerance. Notably, this strategy enables the addition of two distinct electrophiles across an alkene in a highly chemo‐ and regioselective manner.
The early–middle Cambrian siliciclastic tide‐dominated succession in eastern Korea
Authors: Oh Min‐Kyu , Choi Taejin , Lee Jeong‐Hyun 
Published: September 2024

AbstractThe basal Taebaek Group (Myeonsan and Myobong formations) illustrates second‐order transgression on the eastern Sino‐Korean Block during the early–middle Cambrian (Stage 3?–Wuliuan). The irregular palaeotopography of Precambrian basement led to the development of localised alluvial fans and fan deltas. As transgression continued, tidally influenced estuarine and associated shallow subtidal flats developed. Continued transgression resulted in a relatively deep subtidal environment, with postulated carbonate shoals serving as barriers. Stacking of facies indicates a general deepening‐upward trend, transitioning from terrestrial–nearshore to marine environments dominated by tidal effects. The study area subsequently experienced shallowing, leading to the emergence of tidal inlet and dune environments. Siliciclastic input was attenuated, facilitating the development of carbonate shoal complexes. The overall transgressive succession of the basal Taebaek Group aligns with similar sequences observed in the Sino‐Korean Block and western Laurentia, where the lowermost Cambrian strata which formed in various depositional environments on the uneven basement rocks were followed by extensive tide‐dominated siliciclastic successions. These successions were then overlain by epeiric carbonate platforms that developed synchronously across the area as siliciclastic input diminished with the continued transgression. This comparison demonstrates that the transgressive sequences in the Sino‐Korean Block and western Laurentia can be understood within a framework that explains how extensive Cambrian carbonate platforms initially developed due to a second‐order eustatic sea‐level rise during the Cambrian greenhouse period.
The crucial evaluation indexes and relative measurement methods of edible value for fresh fruits and vegetables: A review
Authors: Zhang Yiqin , Wang Hongxuan , Chen Hangjun , Liu Ruiling , Chen Huizhi , Fang Xiangjun , Xiao Jianbo , Wu Weijie , Gao Haiyan 
Published: September 2024

AbstractFresh fruits and vegetables (F&V), with their attractive sensory, flavors, and nutrients, occupy a highly valuable part of people's daily diet. Plenty of postharvest studies have focused on the effects of preservation techniques on the edible quality and nutrients of F&V. Therefore, it is crucial to summarize the research methods of those quality and nutritional indicators for F&V. This work reviews the measurement and analysis methods on these parameters of postharvest F&V which have been validated by numerous publications, including firmness, sugars/acids, pigments, phenols, etc. Importantly, some instruments are involved in these experimental methods, such as firmness tester, spectrophotometer, gas chromatograph, and so on. Furthermore, some promising analysis methods in the past decades combined with advanced technologies are also raised in our discussion. This work is expected to provide guidance and normative significance for future research on quality assessment, preservation, and processing characteristics of F&V.
Cancer‐associated fibroblasts‐derived exosomal ZNF250 promotes the proliferation, migration, invasion, and immune escape of hepatocellular carcinoma cells by transcriptionally activating PD‐L1
Authors: Feng Huizhi , Liu Jingmei , Jia Haixia , Bu Xiaoqian , Yang Wenhui , Su Peng 
Published: September 2024

AbstractHepatocellular carcinoma (HCC) is a lethal form of liver cancer, and the tumor microenvironment, particularly cancer‐associated fibroblasts (CAFs), plays a critical role in its progression. This study aimed to elucidate the mechanism by which CAF‐derived exosomes regulate the development of HCC.The study employed quantitative real‐time polymerase chain reaction for mRNA expression analysis and western blot analysis for protein expression detection. Chromatin immunoprecipitation assay and dual‐luciferase reporter assay were performed to investigate the relationship between zinc finger protein 250 (ZNF250) and programmed cell death 1 ligand 1 (PD‐L1). Transmission electron microscopy and western blot analysis were used to characterize the isolated exosomes. The transferability of CAF‐derived exosomes and normal fibroblasts (NFs)‐derived exosomes into HCC cells was analyzed using a green fluorescent labeling dye PKH67. Cell proliferation was assessed via a 5‐Ethynyl‐2′‐deoxyuridine assay, while Transwell assays were conducted to evaluate cell migration and invasion. Flow cytometry was performed to measure cell apoptosis, while enzyme‐linked immunosorbent assays were used to assess the levels of tumor necrosis factor‐α and perforin. Finally, a xenograft mouse model was constructed to examine the effects of exosomes derived from ZNF250‐deficient CAFs on the tumor properties of HCC cells.The study revealed increased expression of ZNF250 in HCC tissues and cells, with ZNF250 transcriptionally activating PD‐L1 in HCC cells. ZNF250 expression was associated with HbsAg, clinical stage and tumor size of HCC patients. CAF‐derived exosomal ZNF250 can regulate PD‐L1 expression in HCC cells. Furthermore, exosomes derived from ZNF250‐deficient CAFs inhibited the proliferation, migration, invasion, and immune escape of HCC cells by downregulating PD‐L1 expression. Moreover, CAF‐derived exosomal ZNF250 promoted tumor formation in vivo.These findings provide insights into the role of CAF‐derived exosomes in the suppression of HCC development, highlighting the significance of ZNF250 and PD‐L1 regulation in tumor progression.