bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enduring Memory Impairments Provoked by Developmental Febrile Seizures Are Mediated by Functional and Structural Effects of Neuronal Restrictive Silencing Factor
Authors: Patterson Katelin P. , Barry Jeremy M. , Curran Megan M. , Singh-Taylor Akanksha , Brennan Gary , Rismanchi Neggy , Page Matias , Noam Yoav , Holmes Gregory L. , Baram Tallie Z. 
Published: March 2017

In a subset of children experiencing prolonged febrile seizures (FSs), the most common type of childhood seizures, cognitive outcomes are compromised. However, the underlying mechanisms are unknown. Here we identified significant, enduring spatial memory problems in male rats following experimental prolonged FS (febrile status epilepticus; eFSE). Remarkably, these deficits were abolished by transient,post hocinterference with the chromatin binding of the transcriptional repressor neuron restrictive silencing factor (NRSF or REST). This transcriptional regulator is known to contribute to neuronal differentiation during development and to programmed gene expression in mature neurons. The mechanisms of the eFSE-provoked memory problems involved complex disruption of memory-related hippocampal oscillations recorded from CA1, likely resulting in part from impairments of dendritic filtering of cortical inputs as well as abnormal synaptic function. Accordingly, eFSE provoked region-specific dendritic loss in the hippocampus, and aberrant generation of excitatory synapses in dentate gyrus granule cells. Blocking NRSF transiently after eFSE prevented granule cell dysmaturation, restored a functional balance of γ-band network oscillations, and allowed treated eFSE rats to encode and retrieve spatial memories. Together, these studies provide novel insights into developing networks that underlie memory, the mechanisms by which early-life seizures influence them, and the means to abrogate the ensuing cognitive problems.SIGNIFICANCE STATEMENTWhereas seizures have been the central focus of epilepsy research, they are commonly accompanied by cognitive problems, including memory impairments that contribute to poor quality of life. These deficits often arise before the onset of spontaneous seizures, or independent from them, yet the mechanisms involved are unclear. Here, using a rodent model of common developmental seizures that provoke epilepsy in a subset of individuals, we identify serious consequent memory problems. We uncover molecular, cellular, and circuit-level mechanisms that underlie these deficits and successfully abolish them by targeted therapeutic interventions. These findings may be important for understanding and preventing cognitive problems in individuals suffering long febrile seizures.
Increasing ED Use of Jet Injection of Lidocaine for IV-Related Pain Management
Authors: Jain Shobhit , Hegenbarth Mary A. , Humiston Sharon G. , Gunter Erin , Anson Lynn , Giovanni Joan E. 
Published: March 2017

BACKGROUND AND OBJECTIVE:Venipuncture is a leading cause of procedural pain for children. Jet injection of lidocaine (JIL; J-Tip) has been demonstrated to be effective in controlling intravenous (IV) placement–related pain and, due to its rapid onset, is particularly suited to emergency department (ED) use. Our objective was to increase JIL use with IV placements in our ED from 11% at baseline to 50% within 12 months.METHODS:We initiated the project at our urban, tertiary pediatric ED in July 2014. We surveyed medical and nursing teams to identify barriers to JIL use. We initiated changes at monthly intervals: (1) order set changes, (2) online education, (3) hands-on workshops, (4) improved accessibility, (5) standing order policy revision, and (6) reminders. We collected biweekly data on IV placements for all ED patients, except level 1 (critical) triage patients. We used standard quality improvement methodology and statistical process control for statistical analysis.RESULTS:JIL use with IV placement increased to 54% over 7 months and has remained &gt;50% for &gt;12 months. For all eligible IV placements (n = 12 791), 76.4% of those where JIL was used were successful on the first attempt compared with 75.8% without JIL (χ21degrees of freedom = 0.33, P = .56), with no significant difference in the success at IV placement.CONCLUSIONS:We sustainably increased JIL use with IV placement. The use of JIL was not associated with a difference in first-attempt IV placement success rates. We are expanding the project to other parts of the institution.
A questão negra e a imigração européia nos Estados Unidos como modelos para o branqueamento brasileiro – uma ideologia da americanização em Nabuco e Oliveira Lima
Authors: Silveira Helder Gordim da 
Published: March 2017

A partir do Advento da República, o Brasil se orienta sua inserção internacional No sentido de um relativo afastamento da obra européia e uma Aproximação dos Estados Unidos. a Constituição de tal relação assimétrica de poder demandava construção simbólica e o sentido que associasse positivamente ao interesse nacional. Joaquim Nabuco e Oliveira Lima, como intelectuais e políticos, analisando as questões Negra e migratórios Estados Unidos contribuem nesta construção.
Az elhárító mechanizmusok, a vallásosság és a szomatizáció összefüggései
Authors: Terdik Éva , Papp Gábor , Sztancsik Veronika 
Published: March 2017

Elméleti háttér
A vallásossággal kapcsolatos újabb pszichológiai kutatások a vallásosságot coping-mechanizmusként kezelik a betegségekkel való megküzdésnél. Ám a beszámolókban kisebb hangsúlyt kapott az a jelenség, miszerint sok esetben a vallásosság nem pusztán nem járt együtt, hanem kifejezetten negatívan korrelált a betegséghez való alkalmazkodással. Feltételeztük, hogy amit a fent említett kutatások a maladaptív coping hatásának tulajdonítottak, az valójában az elhárító mechanizmusok számlájára írható.

Cél
A vizsgálat célja a vallásosság és az elhárító mechanizmusok közötti kapcsolat fennállásának ellenőrzése volt, kitérve a szomatizációra, mint az éretlenebb elhárító mechanizmusokkal szorosan összefüggő jelenségre.

Módszerek
A keresztmetszeti kérdőíves kutatásban 308 fő vett részt (32,5% férfi, 67,5% nő; átlagéletkor: 28,29 év; szórás: 13,82 év; terjedelem: 14–81 év). A vallásos attitűdformákat a Kritika Utáni Vallásosság Skálával, az elhárító mechanizmusokat a REM-71 kérdőívvel, míg a szomatizációt az SCL-90-R Szomatizáció alskálájával mértük.

Eredmények
A vallási attitűdformák előfordulási gyakorisága a Kritika Utáni Vallásosság Skála alapján a következő: „ortodox” 21,8%, „külső kritika” 39,3%, „relativizmus” 16,6%, „második naivitás” 22,4%. A legfontosabb eredmények azt mutatják, hogy a négy attitűdforma között szignifikáns eltérés mutatkozik az éretlen elhárító mechanizmusok használatában (F(3,307) = 10,905; p < 0,001) és a szomatizáció mértékében (F(3,307) = 4,764; p = 0,003). A mediációs elemzés eredményei szerint a szomatizáció és a szimbolikusság közötti kapcsolat az éretlen elhárító mechanizmusok közvetítő hatásának köszönhető (β = –0,11; p < 0,01).

Következtetések
A vallásos személyeken belül elkülöníthető két eltérő jellegzetességeket mutató csoport: az „ortodox” vallásosak, akik több éretlen elhárító mechanizmust használnak és nagyobb mértékben szomatizálnak, illetve a „második naivitás” csoportja, akikre kevesebb éretlen hárítás és kisebb mértékű szomatizáció jellemző. Ezek az eredmények felhívják a figyelmet arra, hogy a vallásosságot érdemes differenciáltabban szemlélni a segítő szakmák képviselőinek, és nagyobb hangsúlyt helyezni az éretlenebb elhárítások felismerésére és a szimbolikus feldolgozás elősegítésére az „ortodox” csoportban lelki problémák esetén.
Case series of clinical study and surgical management of atlanto axial dislocation our institute experience
Authors: Dasari Ravi , Prasad K. Satyavara , Sandeep B. , Raman B. V. S. 
Published: March 2017

Background: Atlantoaxial dislocation refers to a loss of stability between the atlas and axis (C1-C2), resulting in loss of normal articulation. Cervical spine C1-C2 motion segment is the most technically challenging.Methods: This is a prospective and retrospective Study which included 34 patients admitted in King George hospital, Andhra medical college, Visakhapatnam over the past two years (January 2014- January 2016) with AAD.Results: The age of the patients ranged from 3 to 60 years with mean age being 37.67 years. Commonest presenting sign is local tenderness at the back of upper cervical region in 91.17%. Most common procedure done was single sitting trans oral odontoid decompression with posterior occipito cervical fusion with occipital plate and C2, C4 polyaxial screws and lateral mass rods in 18 cases out of 34. The next common procedure performed was C1 lateral mass and C2 pars screw fixation 8 out of 34.Conclusions: Trans oral odentoidectomy and posterior ocipito cervical fusion is ideal and still holds good for irreducible AAD with ventral compressive pathology.
Argumentación Socrática: Sócrates y la Reducción al Absurdo
Authors: Almanza Eduardo Geovo 
Published: March 2017

Este trabajo analiza una forma especial de argumentación socrática, la reducción al absurdo, tomado como fuente un diálogo de juventud, el Eutifrón. Este argumento elénquico o refutatorio es estudiado en sus dos aspectos principales: por un lado, el que concierne a su estructura más general, como método de investigación moral, y, por otro lado, el aspecto pragmático del diálogo, en el que no se busca ganar el debate sino un diálogo en común para acceder a lo universal. La reducción al absurdo no es simplemente una forma de argumentación entre otras, sino que se la debería entender como la forma de argumentación filosófica que Sócrates considera válida cuando entra a refutar aspectos centrales de un supuesto o hipótesis planteado por su interlocutor. Palabras clave: Argumentación, Reducción al absurdo Diálogo Eutifrón, Sócrates, Argumento indirecto
Traslación, fluidez y vibración a través de La sociedad del semáforo y retratos en un mar de mentiras
Authors: Díaz-Velasco Andrés 
Published: March 2017

Este artículo contiene un análisis de la traslación, el flujo y la vibración, tres conceptos sobre el movimiento, con base en las filosofías de Bergson y Deleuze y a partir de dos filmes colombianos. Con ello se busca un doble propósito: por un lado, recurrir al universo cinematográfico como argumento ejemplar para señalar aspectos imprescindibles de una metafísica vitalista con carácter estéticosobre la agencia humana, y, por el otro, mostrar que no solo en cuestiones de guion, sino en la misma narración cinematográfica, estos, como otros filmes colombianos, están exhibiendo un desarrollo creativo que viene innovando este arte en el país. En la primera parte se trata la traslación y el desplazamiento; en la segunda, el flujo y el corte, y, finalmente, la vibración como conmoción. Seconcluye con un breve análisis político de las imágenes sonora y visual.
La noción de creación deleuziana en la elaboración de material didáctico en lenguas extranjeras
Authors: Pardo-Segura Martha 
Published: March 2017

El objetivo de este artículo es mostrar el resultado del proyecto Investigación y creación de material didáctico en francés, basado en la noción deleuziana de “acto creador” y en aquella de investigación en creación de Schön (1994) asociadas a la reflexión sobre la acción. Este acto de resistencia deleuzianano obedece la distancia entre el investigador, el practicante y el artista porque ella alude al deberser de un docente de lenguas extranjeras según Laurier y Lavoie en el salón de clase por cuanto un maestro está en el lugar y a la hora del entorno del niño. Con el enfoque cualitativo de investigación de tipo etnográfico se desarrollaron cuatro etapas basadas en la descripción de la vida real y del comportamiento del actor social en su medio rural: etapa I (2012): Processus de création d’un manueld’apprentissage du français à l’école de la zone rurale du département de Boyacá; etapas II y III (2013-2014): traducción y adaptación del corpus original del castellano al francés, diseño de las actividades pedagógicas apoyadas e ilustradas con el corpus visual recolectado en la etapa I y ampliado en la etapa II de la investigación ; etapa IV: correspondencia entre los aspectos pedagógicos y los fundamentos teóricos de la investigación y creación del manual. Los resultados señalan la capacidad y competencia creadora de los futuros docentes de lenguas extranjeras, materializadas en el machote del libro Vive la joie en Français.
PENGARUH INTERPRETASI PELAKSANA KEBIJAKAN TERHADAP EFEKTIVITAS PELESTARIAN CENDANA (SANTALUM ALBUM L) DI KABUPATEN TIMOR TENGAH SELATAN (TTS) PROVINSI NUSA TENGGARA TIMUR
Authors: Jeppu Nursalam - 
Published: March 2017

<p>This article aims to provide an overview of factors influence the interpretation of the effectiveness of conservation policy implementers Sandalwood (Santalum album L) in the district of South Central Timor (TTS) East Nusa Tenggara (NTT). Explanatory research design using survey. Sampling technique is stratified sampling, with a size of 145 respondents. Researchers also determined several key persons from various community groups and also from the head of the forest service, the head of the planning department at Sub forestry service, and chief of the office of South Central Timor regency service plan (Bappeda). While the techniques of data collection techniques include questionnaires, observations, interviews, and documentation. Influence the interpretation of the effectiveness of the conservation of sandalwood tested using path analysis. Research conclusion is, the interpretation of policy implementers sandalwood is not maximized in enhancing the effectiveness of conservation Sandalwood. The results also show that there are other factors that need attention if the effectiveness of conservation the of Sandalwood to be improved, the factors of community participation and the factor values are valid, both executive officers and the community.</p><p><strong>Keywords</strong><strong>:</strong> Interpretation, Implementation, Effectiveness, Conservation, Sandalwood (<em>santalum album L</em>).</p>
ANALISIS FAKTOR PENENTU DAYA SAING KOMODITAS PANGAN DI PROVINSI JAWA TENGAH
Authors: Harini . , Purwaningsih Yunastiti , Cahyadin Malik , Widiyanti Emi 
Published: March 2017

<p>This study identifies and analyzes competitiveness factors of food commodities in Central Java. The research data covers primary data with 245 respondents of food commodities sellers. The research method was using the Analytic Hierarchy Process (AHP). AHP calculation results show that food competitivesness factors involve: a) the agricultural sector investment with a value of 0.28; b) agricultural infrastructure with a value of 0.24; c) government program of food security and safety with a value of 0.20; d) government's active role in supervision of food with a value of 0.18; e) the accessibility of local food commodities with a value of 0.06; and f) the high demand for domestic food with a value of 0.05.</p><p> </p><p>Keywords: food commodities, competitiveness, AHP</p>
TRADE OFF BANK ISLAM INDONESIA: MORALITY ATAU BUSINESS ENTITY DALAM PENGELOLAAN LIKUIDITAS
Authors: Kornitasari Yenny 
Published: March 2017

<p>Tujuan dari penulisan ini adalah mengkaji terkait dengan operasional perbankan Islam di Indonesia yang difokuskan dalam permasalahan pengelolaan likuiditas yang dilakukan oleh bank Islam yang ada di Indonesia. Penulisan ini menggunakan pendekatan kualitatif dengan unit analisis wawancara dan observasi yang didukung oleh studi pustaka untuk memberikan gambaran secara sistematis, faktual dan akurat terkait dengan fenomena yang sedang dituliskan dengan hasil kajian berupa konseptual kajian. Berdasarkan pada hasil kajian bahwa perilaku perbankan Islam dalam pengelolaan likuiditas dengan pendekatan kelembagaan menghadapi permasalahan <em>trade off</em> antara keberadaan perbankan Islam sebagai <em>business entity</em> dan keberadaan bank Islam yang berprinsip syarat akan <em>value</em>. Sehingga perkembangan bank Islam saat ini cenderung “permisif” dengan beberapa hal yang bersifat prinsip dalam mendukung perbankan Islam agar berkembang lebih <em>massive</em>. Permasalahan ini muncul lebih banyak dilantarbelakangi oleh keberadaan perbankan Islam di Indonesia yang berkembang dalam mekanisme <em>dual banking system</em>, dimana perbankan Islam berjalan linear dengan perbankan konvensional termasuk dalam menghadapi persaingan bisnis. Hal ini sedikit banyak menimbulkan “ketidakadilan” bagi perbankan Islam itu sendiri, mengingat keberadaa perbankan konvensional sudah jauh berkembang terlebih dahulu daripada perbankan Islam.</p><p> </p><p>Kata Kunci: <em>Bank Islam, Dual Banking, Trade-off</em></p>
The perfect storm: A quadrifecta of complications with takotsubo cardiomyopathy
Authors: Amin Raj , Fritz Timothy , McNamara Richard 
Published: March 2017

Takotsubo cardiomyopathy is generally considered to have a favorable prognosis. However, several major problems may complicate the clinical course. We present a patient with four simultaneous complications of shock, left ventricular thrombus, left ventricular outflow obstruction, and severe mitral regurgitation. Despite this dramatic presentation, the patient had a complete recovery with resolution of all four complications within weeks.
A study on parent’s perception towards children viewing cartoon channels
Authors: Shanthipriya P. , Anish Prabha A. 
Published: March 2017

Television has become a member of every Indian family. Most of the children are eagerly watching cartoon programs on television. This is a subject of research that how television educates the children about various aspect of life and what are the impacts of cartoon programs on children. This study is used to know about children’s interest on type of cartoon and favourite channels and analyzing the parental perception towards children viewing cartoon. This research indicates the positive and negative attitude of rural children towards various aspects of cartoon programs.
A Ilha
Authors: Souza Ricardo Pires de 
Published: March 2017

O planeta Terra é uma ilha, ilha imersa no espaço-tempo einsteiniano, o tecido do universo em que tudo existe. E apesar dessa imensidão inconquistável, somente há pouco – ainda agora, para bem dizer – nos demos conta de que o nosso mundo possui um limite, um limite físico. Nos demos conta de que nossos recursos naturais possuem limites mensuráveis e de que hoje é possível prever com alguma consistência quando irão acabar as reservas de combustível fóssil, quando não mais existirão tigres e leões vivendo livremente na natureza, até quando existirão pandas gigantes, orangotangos, abelhas...
Aerodigestive and Ear Foreign Bodies at Lumbini Medical College
Authors: Acharya Anup , Singh Madan Mohan , Shah Sushil 
Published: March 2017

Introduction: Aerodigestive and Ear foreign bodies are common Ear Nose Throat (ENT) emergencies. They arecommonly encountered by otolaryngologists, paediatricians, and primary care physicians. Objective: The aim ofthis study is to analyze different types of foreign bodies and sociodemographic correlates of self-inflicted foreign body insertion in ear, nose and throat.

Method: Seventy-four patients with aerodigestive foreign body coming to our Hospital over a period of one year, starting from January 1, 2012, were enrolled in the study. Hospital based cross sectional descriptive study was done. Socio-demographic data was collected by history and clinical examination of all those patients. The data collected from 74 patients were entered and analyzed using descriptive and analytical statisticalmethods using SPSS version 17.0.

Result: There were total of 74 cases of ENT foreign body. Male predominance was noted (61%). Foreign body of ear was found to be most frequent (43%) followed by throat (37%) and nose (20%). Foreign body of nose was almost limited in paediatrics population (14 out of 15) whereas in the elderly group foreign body of throat was only found. Seeds, meat bolus or bone or both, insects and cotton bud were the most common foreign bodies. There was significant relation between the type of foreign body and age (p <0.05) and the living foreign body and ear.

Conclusion: Foreign bodies of nose, ear and throat are common in ENT department. They should be timely managed to prevent potential complications.
Impact of Educational Status and Parity of Mother-in-Laws on Practies of Birth Preparedness and Complication Readiness in Banke District
Authors: Acharya Sushma , Ghimire Madhusudhan , Ghimire Maushami 
Published: March 2017

Introduction: Pregnancy and childbirth is considered as a physiological process and it is associated with certain risks to the life of mother and newborn baby. Birth-preparedness and complication readiness is a comprehensive strategy to improve maternal and newborn health. This study was done to observe impact of educational status and Parity of mother-in-laws on awareness and practices regarding birth preparedness and complication readiness.

Methods: The study was conducted in Banke district. The duration of study was from August 2011 to August 2012. Descriptive cross-sectional study was followed. One hundred mothers-in-law were selected through simple random procedure. Semi-structure interview schedule was used to collect information.

Results: The mean age of mothers-in-law was 52.33 (SD=8.96) years. Majority (82.0%) mothers-in-law were illiterate with lack of awareness and practice about birth preparedness and complication readiness.

Conclusion: Inadequate practices on birth preparedness and complication readiness were prevalent in illiterate mothers-in-laws.
Present potential of exfoliative cytology in detection of cervix cancer
Authors: Jain Sushila , Paudel Anuj , Jain S K 
Published: March 2017

Introduction: Conventional Pap smear is the mainstay for cervical cancer screening in developing countries and women should be motivated for cervical screening program to detect early dysplastic cells. This study was carried out to find out the prevalence of abnormalities in Pap smears, particularly pattern of epithelial cell abnormality in women attending Lumbini Medical College in western Nepal.

Methods: A cross-sectional study was carried out and 1066 Pap smears were studied to look for epithelial cell abnormality according to revised Bethesda system 2001.

Results: Out of 1066 patients who underwent Pap smear examination, 71 (6.6%) revealed epithelial cell abnormality; most were low grade squamous intra-epithelial lesions (LSIL) occupying 4.59% at the age between 23 to 29 years. Squamous cell carcinoma was found in 0.37 % of patients at the age 40 years and above. In our scenario, per vaginal discharge was the major finding of the patients who showed premalignant features.

Conclusions: Women above 40 years are at a risk of premalignant as well as malignant lesions and these women should undergo screening for abnormal cells at the age of 18 or when sexual activity starts and as per recommendations to look for early dysplastic cells. Cervical screening program should be motivated by the national policy makers and also by health professionals.