bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shared and unique consequences of Joubert Syndrome gene dysfunction on the zebrafish central nervous system
Authors: Noble Alexandra R. , Masek Markus , Hofmann Claudia , Cuoco Arianna , Rusterholz Tamara D. S. , Özkoc Hayriye , Greter Nadja R. , Phelps Ian G. , Vladimirov Nikita , Kollmorgen Sepp , Stoeckli Esther , Bachmann-Gagescu Ruxandra 
Published: October 2024

ABSTRACT
Joubert Syndrome (JBTS) is a neurodevelopmental ciliopathy defined by a highly specific midbrain–hindbrain malformation, variably associated with additional neurological features. JBTS displays prominent genetic heterogeneity with &gt;40 causative genes that encode proteins localising to the primary cilium, a sensory organelle that is essential for transduction of signalling pathways during neurodevelopment, among other vital functions. JBTS proteins localise to distinct ciliary subcompartments, suggesting diverse functions in cilium biology. Currently, there is no unifying pathomechanism to explain how dysfunction of such diverse primary cilia-related proteins results in such a highly specific brain abnormality. To identify the shared consequence of JBTS gene dysfunction, we carried out transcriptomic analysis using zebrafish mutants for the JBTS-causative genes cc2d2aw38, cep290fh297, inpp5ezh506, talpid3i264 and togaram1zh510 and the Bardet-Biedl syndrome-causative gene bbs1k742. We identified no commonly dysregulated signalling pathways in these mutants and yet all mutants displayed an enrichment of altered gene sets related to central nervous system function. We found that JBTS mutants have altered primary cilia throughout the brain but do not display abnormal brain morphology. Nonetheless, behavioural analyses revealed reduced locomotion and loss of postural control which, together with the transcriptomic results, hint at underlying abnormalities in neuronal activity and/or neuronal circuit function. These zebrafish models therefore offer the unique opportunity to study the role of primary cilia in neuronal function beyond early patterning, proliferation and differentiation.
Advances in systemic treatment for recurrent metastatic cervical cancer
Authors: Kang Guohui , Du Weimin , Zeng Shu , Wu Xiaomei 
Published: October 2024

Cervical cancer remains a leading cause of cancer-related mortality among women worldwide, particularly in underdeveloped nations. Despite advances in standard therapies, patients with recurrent metastatic cervical cancer face a poor prognosis and limited treatment options. This study aims to evaluate the efficacy and safety of emerging therapeutic approaches in managing this challenging condition, including immunotherapy, targeted medicines, and chemotherapy. Our review of recent literature and clinical trials highlights the significant progress made in the systematic treatment of metastatic cervical cancer. While each treatment modality has its strengths and limitations, the collective data suggest a trend towards improved patient outcomes with the adoption of these novel therapies. However, the heterogeneity of patient responses underscores the need for personalised treatment strategies. In conclusion, improvements in medical technology and the adoption of tailored treatment approaches have led to promising advancements in the management of recurrent metastatic cervical cancer. To further enhance patient care, there is an urgent need for more extensive clinical trial data and the development of more efficient personalised treatment plans. This study aims to contribute to this effort by comprehensively analysing current therapeutic strategies and identifying areas for future research.
Identifying Sensors Data Integrity Threats of Smart Agriculture: A Collaborative Filtering Approach
Authors: Bissadu Kossi Dodzi , Hossain Gahangir , Velagala Leela Pavani 
Published: October 2024

HighlightsData integrity threat is one of the challenges faced by smart agriculture, where humans make complex decisions based on the results and recommendations of automated farm/livestock monitoring systems.Smart or digital farming heavily relies on data, which can face various integrity threats including data modification, data destruction, etc.The use of collaborative filtering as a lightweight method to detect abnormal data has proven effective from our experimental study. It can detect suspicious data with high accuracy and precision enhancing digital agricultural security.Abstract. Smart agriculture leverages human intelligence and artificial intelligence in digital farming, which heavily relies on data collection, analysis, and decision support delivery. Farmers need reliable data and a decision support system to make accurate decisions and take appropriate actions. The Internet of Things (IoT) not only creates the backbone for farm data collection for intelligent farming but also brings some security concerns to the agriculture field. Though many studies exist on security in agriculture, particularly device identification and tracking, cryptography, blockchain, and other security approaches, the concerns about agricultural data integrity have not been fully explored in the current literature. Data integrity threats could cause huge losses to farmers, threatening food security, especially in developing countries. Given the early stage of development in the domain and the rapid adoption of IoT, ensuring the trustworthiness of data from various devices poses a significant challenge. This challenge is exacerbated in wireless sensor network scenarios, particularly in harsh environments where potential avenues for physical attacks exist. This article evaluates a data integrity threat detection technique in an IoT wireless network. It proposes an approach to identify potential data integrity failures or threats. The effectiveness of this approach is demonstrated through an empirical use-case study focusing on agriculture applications. Through experimental and trace-based simulations, we illustrate that threats can potentially be identified with a 91% accuracy rate and approximately 98% precision and recall. The proposed solution could be deployed in distributed and centralized digital agricultural systems to identify and predict real-time data integrity issues or threats. Keywords: Collaborative filtering, Data integrity threats, Local outlier factor, Smart agriculture.
Comparison of Infrared Thermometry and Soil Water Derived Stress Indices and Crop ET in Cotton
Authors: Schwartz Robert C. , Colaizzi Paul D. , Domínguez Alfonso , Baumhardt R. Louis , Ulloa Mauricio 
Published: October 2024

HighlightsA crop water stress index (CWSI) was calculated using a theoretical approach.Averaged daily rather than one to two hour daily maximum CWSI correlated better with soil-based crop water stress.Crop ET scaled with the CWSI accurately predicted ET for a dissimilar canopy and irrigation level.Sub-hourly canopy resistance and transpiration were inferred from canopy temperature measurements.Abstract. Upland cotton (Gossypium hirsutum L.) is increasingly being managed under subsurface drip irrigation (SDI) in the semiarid Texas High Plains (THP). Scheduling irrigation using a thermally based crop water stress index (CWSI) has the potential to overcome limitations of soil water-based methods and facilitate efficient use of water. The objectives of this study were to develop a CWSI calculation procedure using stability correction, determine an appropriate window for averaging CWSI during daytime hours, compare CWSI with soil water-based indicators of crop water stress, and evaluate methods for estimating crop evapotranspiration (ET) using measured canopy temperatures. Infrared thermometer measurements of canopy temperature and corresponding cotton water use derived from soil water measurements were acquired under two irrigation levels (100% and 33%) under SDI during three growing seasons. A theoretical approach was used to calculate the CWSI using the Businger-Dyer stability correction. Basing daily CWSI on short 1- or 2-h periods in the afternoon overestimated crop water stress. In contrast, CWSI averaged during daytime periods with 0.25-h solar radiation and air temperature exceeding 0.3 MJ m-2 and 24°C, respectively, was strongly correlated (R2=0.76) with the soil water depletion-based stress coefficient Ks with a plausible lower canopy resistance of 25 s m-1. The CWSI was weakly correlated (R2=0.48) to the fraction of plant available water, with the CWSI exhibiting the greater increase of these two indices in response to irrigation events. Using the proposed CWSI scaling at different locations for canopies with dissimilar cover fractions yielded satisfactory estimates of crop ET (RMSE=0.74 mm d-1) compared with soil water balance-calculated ET (ETswb). When summed over weekly intervals, energy balance predictions of 0.25-h crop transpiration inferred from canopy temperature measurements had an acceptable agreement with ETswb (RMSE=0.92 mm d-1). Employing the CWSI to trigger irrigation will require targeted field studies to evaluate thresholds and strategies to optimize water management. Keywords: Canopy temperature, Crop water stress index, Evapotranspiration, Subsurface drip irrigation, Upland Cotton.
Segmented protection scheme based on maximum bandwidth sharing in F5G
Authors: Liu Wenhong , Zhao Yongli , Li Yajie , Li Xin , Rahman Sabidur , Zhang Jie 
Published: October 2024

As guaranteed reliable experience (GRE) is one of the features of fifth-generation fixed networks (F5G), high-reliability optical transport networks (OTNs) have become one of the key technologies supporting this feature. Unfortunately, current OTN protection methods often provide fixed bandwidth for protection of 1 Gbps or more, which leads to resource wastage. Fine grain OTN (fgOTN) is an extension of existing OTN, which supports hitless bandwidth adjustment and uses 10 Mbps time slot isolation. The application of fgOTN’s advantages to network protection can save resources. However, how much initial protection bandwidth is reserved for links to improve the service recovery success probability after faults is a key issue to be studied. If the initially reserved protection bandwidth is too much, that may waste precious bandwidth resources and fail to recover other services. If the initially reserved protection bandwidth is too small, the controller needs to adjust the bandwidth frequently to meet service requirements, which puts tremendous pressure on network management and control. This study proposes a maximum bandwidth segmented shared protection (MBSSP) scheme, which is based on optimized centralized and distributed collaboration network management architecture. The protection scheme includes two algorithms: (i) the resource reservation algorithm used before the fault occurs based on maximum bandwidth segmented shared protection and (ii) the protection switch algorithm used after the fault occurs based on bandwidth adjustment. Simulative results show that, in a 38-node topology, compared with minimum bandwidth dedicated protection (MBDP), MBSSP only sacrifices 0.8% of resource utilization but can reduce the bandwidth adjustment probability by 15.8% and improves the recovery success probability by 33.4%. Compared with end-to-end shared protection (E2ESP), MBSSP improves recovery success probability by 42.9% and saves resources by 16.7%, although it increases the bandwidth adjustment probability by 20%.
Impact of different blood pressure targets on cerebral hemodynamics in septic shock: A prospective pilot study protocol—SEPSIS-BRAIN
Authors: Cury Pedro , Passos Rogério da Hora , Alves Fernanda , Brasil Sérgio , Frigieri Gustavo , Taccone Fabio S. , Panerai Ronney B. , Caldas Juliana 
Published: October 2024

Introduction
Septic shock, a life-threatening condition, can result in cerebral dysfunction and heightened mortality rates. In these patients, disturbances in cerebral hemodynamics, as reflected by impairment of myogenic cerebral autoregulation (CA), metabolic regulation, expressed by critical closing pressure (CrCP) and reductions in intracranial compliance (ICC), can adversely impact septic shock outcomes. The general recommendation is to maintain a target mean arterial pressure (MAP) of 65 mmHg but the effect of different MAP targets on cerebral hemodynamics in these patients is not clear and optimal targets might be dependent on the status of CA. This protocol aims to assess the cerebral hemodynamics profile at different pressure targets in septic shock patients.

Methods
Prospective, non-randomized, single-center trial, which will study cerebral hemodynamics in patients with septic shock within 48 hours of its onset. Patients will be studied at their baseline MAP and at three MAP targets (T1: 65, T2: 75, T3: 85 mmHg). Cerebral hemodynamics will be assessed by transcranial Doppler (TCD) and a skull micro-deformation sensor (B4C). Dynamic CA will be expressed by the autoregulation index (ARI), calculated by transfer function analysis, using fluctuations of MAP as input and corresponding oscillations in cerebral blood velocity (CBv). The instantaneous relationship between arterial blood pressure and CBv will be used to estimate CrCP and resistance-area product (RAP) for each cardiac cycle using the first harmonic method. The B4C will access ICC by intracranial pressure waveforms (P2/P1). The primary aim is to assess cerebral hemodynamics (ARI, CrCP, RAP, and P2/P1) at different targets of MAP in septic shock patients. Our secondary objective is to assess cerebral hemodynamics at 65mmHg (target recommended by guidelines). In addition, we will assess the correlation between markers of organ dysfunction (such as lactate levels, vasoactive drugs usage, SOFA score, and delirium) and CA.

Ethics and dissemination
The results of this study may help to understand the effect of the recommended MAP and variations in blood pressure in patients with septic shock and impaired CA and ICC. Furthermore, the results can assist large trials in establishing new hypotheses about neurological management in this group of patients. Approval was obtained from the local Ethics Committee (28134720.1.0000.0048). It is anticipated that the results of this study will be presented at national and international conferences and will be published in peer-reviewed journals in 2024 and 2025.

Trial registration
Trial registration number: NCT05833607. https://clinicaltrials.gov/study/NCT05833607.
Design and 3D simulation of weft-knitted jacquard plush fabrics
Authors: Mu Xiuping , Jiang Gaoming , Guan Songsong , Liu Haisang , Li Bingxian 
Published: October 2024

Abstract
Weft-knitted jacquard plush fabrics are widely used and have a wide variety of varieties, but the design and production process is complicated, time-consuming, and labor-intensive. To reduce the time and cost of fabric sampling and production, a method for designing and simulating these fabrics is proposed based on an analysis of their structural characteristics. Following the design principles of weft-knitted jacquard plush fabrics, mathematical models for pattern design and structural design were established sequentially, leading to the generation of a mathematical model for the knitting diagram. Arrays for raw material editing and threading editing were created to set various parameters. Second, loop models were established based on plush loop shapes, including a forming loop model, a U-shaped loop model, a Henkel plush loop model, a “8”-shaped plush loop model, and a O-shaped plush loop model. Finally, the effects of lighting and number of segments were investigated in THREE.Tube Geometry on the simulation’s effectiveness and speed. By comparing actual fabric images with simulation images, the feasibility of the design and simulation method was verified. This resulted in a computer-aided design process for weft-knitted jacquard plush fabrics, providing an effective method for their design and simulation. The proposed method holds significant theoretical and practical values.
Research Libraries’ Diverse Orientations to an Algorithmic Future
Authors: Kautonen Heli 
Published: October 2024

Abstract
This article addresses the question of the future of research libraries by exploring the recent literature on libraries and artificial intelligence (AI) or – as we prefer to call these emerging technologies – algorithms. We apply the anthropological concepts of the future by Bryant and Knight as lenses of analysis and identify examples from the literature under six future orientations: anticipation, expectation, speculation, potentiality, hope, and destiny. Through the examples that describe research libraries’ approaches to algorithm-powered technologies, we aim to demonstrate that there are alternative time views for approaching the future. By questioning our narratives about the new technologies, we aim to join the collective deliberation on algorithmic futures.
Utilizing peer evaluation as a collaborative learning tool: fostering autonomy satisfaction in English presentation classes
Authors: Kireeti Kushal , Egitim Soyhan , Thomson Blair John 
Published: October 2024

Abstract
The present two-phased sequential explanatory mixed-methods research investigates first and second-year Japanese university students’ perceptions of peer evaluation through self-reflection and its relation to learner autonomy satisfaction in English presentation activities. First, the qualitative data were collected through an open-ended survey questionnaire (n = 17). The findings revealed that students held a positive view of the peer evaluation process, which was facilitated by structured evaluation criteria developed collaboratively with the students using the Leaderful Classroom Practices framework. Furthermore, students’ ownership of the evaluation process enhanced their motivation and commitment to their own presentations. To explore the relationship between the peer evaluation process and students’ autonomy satisfaction, we conducted a survey with advanced-level first-year English major students (n = 87). Despite the small sample size, our multiple regression analysis also supported the qualitative findings, indicating a significant correlation between peer evaluation and learner autonomy satisfaction in English presentation activities. While peer-based activities have been thoroughly studied in the context of academic writing courses, we recommend that the influence of peer evaluation activities on learner autonomy satisfaction be further explored in oral communication activities within the Japanese university EFL settings.
Extension of Fejér's inequality to the class of sub-biharmonic functions
Authors: Jleli Mohamed 
Published: October 2024

Abstract
Fejér’s integral inequality is a weighted version of the Hermite-Hadamard inequality that holds for the class of convex functions. To derive his inequality, Fejér [Über die Fourierreihen, II, Math. Naturwiss, Anz. Ungar. Akad. Wiss. 24 (1906), 369–390] assumed that the weight function is symmetric w.r.t. the midpoint of the interval. In this study, without assuming any symmetry condition on the weight function, Fejér’s inequality is extended to the class of sub-biharmonic functions, namely, the set of functions

f
∈

C

4

(

I

)

f\in {C}^{4}\left({\mathbb{I}})

satisfying

f

″
″

≤
0

{f}^{^{\prime\prime} ^{\prime\prime} }\le 0

, where

I

{\mathbb{I}}

is an interval of

R

{\mathbb{R}}

. In the special case when the weight function is symmetric w.r.t. the midpoint of some interval, and the function

f

f

is convex and sub-biharmonic, an interesting refinement of Fejér’s inequality is deduced. Moreover, this inequality is extended to a new class of functions defined on the plane, that we call the set of sub-biharmonic functions on the coordinates. Assuming in addition that the function is convex on the coordinates, a refinement of an inequality due to Dragomir [On the Hadamard’s inequality for convex functions on the co-ordinates in a rectangle from the plane, Taiwan. J. Math. 5 (2001), 775–788] is obtained.
Influence of heat treatment on metallurgical and mechanical properties of aluminium Al6061 hybrid metal matrix composites
Authors: Pradeep A. Devaenthiran , Rameshkumar Thirupathi 
Published: October 2024

Abstract
The current investigation explores the metallurgical and mechanical properties of hybrid metal matrix composites (HMMC) with aluminum 6061 as the base material, reinforced with ceramic of tungsten carbide (WC) nanoparticles, graphite (as a solid lubricant) and redmud (RM). Four different composites with tungsten carbide nanoparticles (1.5 wt.%) and graphite (2 wt.%) with a varying proportions of redmud (0, 1, 3 and 5 wt.%) are fabricated by stir casting. Microscopic analysis reveals grain boundary with segregations, some of which dissolve to form discontinuous grain boundaries after heat treatment. FESEM examination shows the formation of intermetallic, some of which dissolve on heat treatment to form precipitate that are distributed evenly along the grain boundary and also inside grains. EDX mapping further validated the uniform distribution of reinforcements without any agglomeration. The addition of reinforcements and heat treatment (T6) resulted in substantial improvements in hardness, ultimate tensile strength, yield strength, and compressive strength compared to unreinforced Al6061 and untreated HMMC, respectively. Fractographic analysis of tensile tested samples reveals the presence of dimples, tearing edges and small voids, indicating ductile fracture.
Foucault’s Culturalist Axiomatic: A Nietzschean Naturalist Rejoinder
Authors: Vrdoljak Tvrtko 
Published: October 2024

Abstract
The Nietzsche-Foucault relationship has been the subject of extensive scholarship, highlighting their affinity. In contrast, this paper foregrounds what I take to be their most significant point of divergence: it compares Nietzsche’s naturalist to Foucault’s culturalist axiomatic of power. First, I introduce a minor, naturalist tradition in the philosophy of power that culminates with Nietzsche. Second, I show how Foucault revolutionized the field of political thought and analysis by drawing on Nietzsche’s critique of logocentrism, and in so doing introduced a different and significantly more expansive image of politics. Third, I survey Foucault’s key writings on power to support the claim that the contrast between Nietzsche and Foucault can be described in terms of a contrast between naturalism and culturalism. Finally, I follow this theme in the writings of “new materialist” thinkers and their ambiguous reception of Foucault. Although Foucault is often read as politicizing Nietzsche, his circumscribing of power-relations to intra-human relations alone, and thereby confining politics to human cultures, in effect led to him depoliticizing Nietzsche.
Recent advances in organelle-specific autophagy in melanoma
Authors: Qi Jinxin , Zhang Qian , Wang Lian , Wen Xiang , He Gu , Jiang Xian 
Published: October 2024

Abstract
Organelle-specific autophagy, the selective degradation of distinct cellular organelles, plays a pivotal role in the pathogenesis and progression of various diseases, including melanoma. This review provides a comprehensive analysis of recent advances in organelle-specific autophagy in melanoma, focusing on key processes such as mitophagy, reticulophagy, lysophagy, nucleophagy, pexophagy, and ribophagy. Emerging evidence highlights the roles these autophagic pathways play in melanoma development, with each process contributing uniquely to tumor cell proliferation, migration, invasion, and resistance to therapy. Mitophagy, for example, can both support tumor growth by enhancing mitochondrial quality and suppress it by inducing cell death. Similarly, ER stress exhibits a dual regulatory role, promoting either drug resistance or apoptosis depending on the context, with reticulophagy playing a critical role in modulating these effects. These findings emphasize the importance of further exploring organelle-specific autophagy as both a potential therapeutic target and a prognostic biomarker in melanoma. This research holds significant promise for the development of novel clinical strategies aimed at improving patient outcomes.