bluuebunny/crossref_metadata_2025_split huggingface dataset:
Web mining for the mayoral election prediction in Taiwan
Authors: Huang Jia-Yen 
Published: September 2017

PurposeThe prediction of pre-election polls is an issue of concern for both politicians and voters. The Taiwan nine-in-one election held in 2014 ended with jaw-dropping results; apparently, traditional polls did not work well. As a remedy to this problem, the purpose of this paper is to utilize the comments posted on social media to analyze civilians’ views on the two candidates for mayor of Taichung City, Chih-chiang Hu, and Chia-Lung Lin.Design/methodology/approachAfter conducting word segmentation and part-of-speech tagging for the collected reviews, this study constructs the opinion phrase extraction rules for identifying the opinion words associated with the attribute words. Next, this study classifies the attribute words into six municipal governance-related topics and calculates the opinion scores for each candidate. Finally, this study uses correspondence analysis to transform opinion information on the candidates into a graphical display to facilitate the interpretation of voters’ views.FindingsThe results show that the topics of candidates’ backgrounds and transport infrastructure were the two most critical factors for the election prediction. Based on the predication, Lin outscores Hu by 17.74 percent which is close to the real election results.Research limitations/implicationsThis study proposes new rules for the extraction of Chinese opinion words associated with attribute words.Practical implicationsThis study applies Chinese semantic analysis to assist in predicting election results and investigating the topics of concern to voters.Originality/valueThe proposed opinion phrase extraction rules for Chinese social media, as well as the election forecast process, can provide valuable references for political parties and candidates to plan better nomination and election strategies.
What makes a competent change manager? The importance of developing the “right” attitudes
Authors: Hoe Siu Loon 
Published: September 2017

Purpose
The purpose of this paper is to highlight the importance of developing the “right” attitudes toward change.

Design/methodology/approach
The viewpoint is based on more than 20 years of experience gained and insights developed through consulting projects and training conducted for numerous multinational companies and public sector organizations across Asia. An overview of international and national competency frameworks that include change management from Australia, United Kingdom, and Singapore is also presented.

Findings
A competent change manager requires a combination of knowledge, skills, and attitude to effect change. While knowledge and skills have traditionally been emphasized, there is a need to develop the “right” attitude as well.

Research limitations
This article is based on the author's personal viewpoint which may be subjective.

Practical limitations
The paper provides researchers with an insight on the importance of attitudes as a key contributing factor to change management competency. For the practitioners, it provides another perspective for designing more effective education programs to train change managers with an emphasis on attitudes.

Originality/value
This paper contributes to the existing change management literature by providing insights on the importance of competency, in particular, the “right” attitude required of a change manager.
A set of constitutive functions for dried body to predict entire deformation process of ceramic products during firing
Authors: Matsubara Seishiro , Tarada Kenjiro , Kobayashi Takaya , Saitou Toshiyuki , Umeda Manabu , Mihara Yasuko , Oide Kai , Shin Hiroto , Katsuda Yasuhiro 
Published: September 2017

Purpose
The purpose of this paper is to propose a set of constitutive functions for dried bodies for accurate prediction of the entire deformation process of ceramic products during firing and to present relevant methods for determining their coefficients from a series of respective thermo-mechanical analysis (TMA) tests.

Design/methodology/approach
The function forms of the sintering-induced strain rate, viscoplastic multiplier and elastic modulus are formulated in order with reference to empirical data of relative densities. Separate TMA tests are conducted to identify their coefficients, while a stairway thermal cycle test is carried out to identify the parameters in the densification rate. Then, various finite element analyses (FEA) are performed for accuracy confirmation.

Findings
The performances of the present constitutive functions along with the identified material parameters were validated in comparison with the relevant test results. It has then been confirmed that these functions enable us to some extent to accurately estimate the non-mechanical and mechanical deformations of dried bodies during firing. Also, by performing FEA of an actual sanitary ware product, the applicability and capability of the proposed set of constitutive functions could be demonstrated.

Practical implications
The present methodology with the proposed constitutive functions is a simple, but reliable and practical approach for simulating the deformation process of arbitrary ceramic products subjected to firing and applicable for practical applications in various engineering fields.

Originality/value
The constitutive functions of the viscoplastic multiplier and elastic modulus, which enable us to properly characterize the mechanical behavior of dried bodies subjected to firing, are originally formulated in analogy with that of the sintering-induced strain.
Mental Wellbeing Impact Assessment (MWIA) in the workplace
Authors: Burford Charlotte , Davey Silvia , Knight Alec , King Sadie , Cooke Anthea , Coggins Tony 
Published: September 2017

Purpose
The Mental Wellbeing Impact Assessment (MWIA) is an evidence-based tool that guides decision makers, such as policy makers and service managers, about the potential impacts of a new programme or policy change. It was initially used in urban regeneration but has subsequently been used in housing, children’s centres and education. The purpose of this paper is to report, for the first time, on the strengths and weaknesses of using the MWIA in the workplace.

Design/methodology/approach
Feedback was collected from staff who participated in stakeholder workshops as part of the MWIA process at two different public sector organisations.

Findings
The MWIA can be used as an effective workplace assessment tool and is valuable as both a diagnostic tool and as an intervention in its own right. The MWIA generates tailored action plans focussed on addressing the organisation or team-specific issues. The weaknesses of the MWIA in the workplace are mainly focussed around management cooperation and commitment to the process which should be screened for prior to engaging in the full stakeholder workshop.

Originality/value
This is the first report of MWIA’s use in the workplace but suggests that it is a useful tool which can be used to support workplace wellbeing, especially in relation to a policy or organisational change. Further studies should be carried out to fully understand the impact of the MWIA in the workplace.
A multi-level test for social regulatory focus and team member creativity
Authors: Lin Chen-Ju 
Published: September 2017

PurposeIn this study, self-leadership strategy serves as a self-regulatory mediating mechanism of individual differences in predicting individual creativity because it is related to actions intended to lead their own goal-directed activities. The purpose of this paper is to explore the boundary conditions of the effect of regulatory focus on employee self-leadership behaviors.Design/methodology/approachConsidering the contextual influence, cross-level moderating effect of empowering leadership on the relationship between the promotion (prevention) focus and self-leadership has been examined. The research data were collected from 441 employees of 65 work teams from three software companies located in Northern Taiwan. A time-lagged design by implementing three time surveys was applied to minimize potential problems of cross-sectional design. At Time 1, employees completed the measures of promotion focus, prevention focus, empowering leadership, and individual-level control variables. At Time 2, employees reported the extent of their self-leadership at work. In the final survey, team leaders assessed the individual employee creativity.FindingsThis study concludes several findings. When self-leading behavior-focused strategies are considered as mediators, the indirect relationships that promotion focus and prevention focus had with individual creativity were confirmed. As an influential team-level indicator, empowering leadership could moderate the relatedness between employees promotion-focused strategies and behavior-focused strategies that positively influenced on individual creativity.Originality/valueIn this study, responding to the call by De Stobbeleiret al.(2011) to examine how employees actively manage their creative performance, the author zoomed in on self-leadership strategies and how these strategies relate to actual creative performance.
Separation and purification of hypocholesterolaemic peptides from whey protein and their stability under simulated gastrointestinal digestion
Authors: Jiang Chen , Liu Lu , Li Xiaodong , Ma Liyuan , Du Lingling , Zhao Yongbo , Li Donghua , Zhao Weili 
Published: September 2017

In this study, hypocholesterolaemic peptides were separated from whey protein trypsin hydrolysates (WPTHs) and the inhibition of cholesterol micellar solubility (ICMS) and the stability of hypocholesterolaemic peptides after exposure to simulated gastrointestinal conditions were evaluated. Whey protein trypsin hydrolysates were concentrated by ultrafiltration and then desalted through macroporous adsorption resin DA201‐C. Sephadex G‐50 gel filtration chromatography was used to separate the hypocholesterolaemic peptides from the fraction eluted with 75% ethanol. The results suggested that the fraction obtained by gel filtration with a molecular weight (MW) ranging from 1900 Da to 3100 Da exhibited the highest hypocholesterolaemic activity. This fraction was further separated by reversed‐phase high‐performance liquid chromatography into 14 fractions; the peptides with the highest activities were obtained from the fifth peak with a MW of 2454 Da and 58.77% ICMS. The hypocholesterolaemic peptides were relatively stable when exposed to simulated gastrointestinal digestion.
FGF19 genetic amplification as a potential therapeutic target in lung squamous cell carcinomas
Authors: Zhang Xiaochen , Kong Mei , Zhang Zhen , Xu Suzhen , Yan Feifei , Wei Liyuan , Zhou Jianying 
Published: September 2017

BackgroundAlthough FGF19 gene aberrations are associated with carcinogenesis and progression in human cancers, the roles of FGF19 genetic amplification and expression in Chinese patients with lung squamous cell carcinoma (LSCC) and FGF19 amplification as a potential therapeutic target for LSCC are not well understood.MethodsFluorescence in situ hybridization analysis and quantitative real‐time‐PCR was used to detect FGF19 genetic amplification and FGF19 messenger RNA expression in LSCC tumor and paired adjacent samples. Small interfering RNA and short hairpin RNA were used to knockdown FGF19 in vitro and in vivo.Results
FGF19 amplification was identified in a subset of LSCC patients (37.5%, 15/40), and upregulation of FGF19 expression was found in 60% (24/40) of tumor tissues compared to adjacent non‐tumorous tissues. Correlation analysis with clinicopathologic parameters showed that FGF19 upregulation was significantly associated with heavy smoking. Small interfering RNA knockdown of FGF19 led to the significant inhibition of cell growth and induced apoptosis in LSCC cells carrying the amplified FGF19 gene, but these effects was not observed in non‐amplified LSCC cells. Interfering FGF19 expression with short hairpin RNA also resulted in tumor growth inhibition and induced apoptosis in LSCC xenografts with amplified FGF19 in tumor cells.ConclusionOur results suggested that FGF19 signaling activation is required for cell growth and survival of FGF19 amplified LSCC cells, both in vitro and in vivo. Intervention of FGF19 activation could be a potential therapeutic strategy for LSCC patients with FGF19 amplification.
Impact of shoulder dystocia, stratified by type of manoeuvre, on severe neonatal outcome and maternal morbidity
Authors: Michelotti Flurina , Flatley Christopher , Kumar Sailesh 
Published: September 2017

BackgroundShoulder dystocia is an uncommon and unpredictable obstetric emergency. It is associated with significant neonatal, maternal and medico‐legal consequences.AimTo ascertain the impact shoulder dystocia has on severe neonatal and maternal outcomes specific to the type of manoeuvre.Materials and methodsThis was a retrospective study of 48 021 term singleton vaginal deliveries the Mater Mothers' Hospital in Brisbane between 2007 and 2015. Maternal and neonatal outcomes were compared between deliveries complicated by shoulder dystocia and those uncomplicated.ResultsDeliveries complicated by shoulder dystocia are associated with low Apgar scores (≤3) at five minutes (odds ratio (OR) 5.25, 95% CI 3.23–8.56, P < 0.001), acidosis (OR 3.10, 95% CI 2.76–3.50, P < 0.001), postpartum haemorrhage (OR 2.28, 95% CI 1.90–2.75, P < 0.001) and perineal trauma (OR 1.92, 95% CI 1.54–2.39, P < 0.001). Compared to McRoberts' manoeuvre and suprapubic pressure alone, the odds of serious neonatal outcome are increased with internal rotational manoeuvres (OR 3.82, 95% CI 2.54–5.74, P < 0.001) and delivery of the posterior arm (OR 4.49, 95% CI 3.54–5.69, P < 0.001). The OR of maternal injury is 2.07 (95% CI 1.77–2.45, P < 0.001), 2.26 (95% CI 1.21–4.21, P < 0.001) and 2.29 (95% CI 1.58–3.32, P < 0.001) with McRoberts'/suprapubic pressure, internal rotation and posterior arm delivery, respectively. Brachial plexus injuries and fractures complicate 1.4 and 0.9% of deliveries, with the risk of injury increasing when greater than one manoeuvre is required.ConclusionThe risk of neonatal and maternal trauma is strongly associated with the number and types of manoeuvres. Given the associated implications, adequate antenatal counselling, simulation training and enhanced labour surveillance are essential.
Nutritive value and fermentation quality of palisadegrass and stylo mixed silages
Authors: da Silva Juliana S. , Ribeiro Karina G. , Pereira Odilon G. , Mantovani Hilário C. , Cecon Paulo R. , Pereira Rosana C. , Silva Janaina de L. 
Published: September 2017

AbstractThe nutritive value and fermentation quality of palisadegrass (Brachiaria brizantha cv. Xaraes) and stylo (Stylosanthes capitata × S. macrocephala cv. Campo Grande) mixed silages were evaluated. The experiment was analyzed in a factorial scheme (5 × 2) in a completely randomized design using increasing levels of stylo (0, 25, 50, 75 and 100% on a fresh matter basis) on palisadegrass silages, with and without microbial inoculants (MI). With the increased ratio of stylo in mixed silages, dry matter (DM), crude protein (CP), acid detergent fiber (ADF), and lignin content increased in silages. The presence of MI promoted lower DM content, and higher neutral detergent fiber corrected for ash and protein, ADF and lignin content. The acid detergent insoluble nitrogen content and the lactic acid bacteria populations were not affected by treatments. The in vitroDM digestibility was affected by the interaction of levels of the stylo and MI. The pH, NH3‐N/total nitrogen and butyric acid concentrations decreased with increasing levels of stylo. Better nutritive value and quality of fermentation was found in the silage containing higher proportions of this stylo mixed with palisadegrass. The microbial inoculant evaluated did not alter the nutritive value or quality of the fermentation of the silages in this experiment.
PDE1A inhibition elicits cGMP‐dependent relaxation of rat mesenteric arteries
Authors: Khammy Makhala Michell , Dalsgaard Thomas , Larsen Peter Hjørringgaard , Christoffersen Claus Tornby , Clausen Dorte , Rasmussen Lars Kyhn , Folkersen Lasse , Grunnet Morten , Kehler Jan , Aalkjær Christian , Nielsen Jacob 
Published: September 2017

Background and PurposePDE1, a subfamily of cyclic nucleotide PDEs consisting of three isoforms, PDE1A, PDE1B and PDE1C, has been implicated in the regulation of vascular tone. The PDE1 isoform(s) responsible for tone regulation is unknown. This study used isoform‐preferring PDE1 inhibitors, Lu AF58027, Lu AF64196, Lu AF66896 and Lu AF67897, to investigate the relative contribution of PDE1 isoforms to regulation of vascular tone.Experimental ApproachIn rat mesenteric arteries, expression and localization of Pde1 isoforms were determined by quantitative PCR and in situ hybridization, and physiological impact of PDE1 inhibition was evaluated by isometric tension recordings.Key ResultsIn rat mesenteric arteries, Pde1a mRNA expression was higher than Pde1b and Pde1c. In situ hybridization revealed localization of Pde1a to vascular smooth muscle cells (VSMCs) and only minor appearance of Pde1b and Pde1c. The potency of the PDE1 inhibitors at eliciting relaxation showed excellent correlation with their potency at inhibiting PDE1A. Thus, Lu AF58027 was the most potent at inhibiting PDE1A and was also the most potent at eliciting relaxation in mesenteric arteries. Inhibition of NOS with l‐NAME, soluble GC with ODQ or PKG with Rp‐8‐Br‐PET‐cGMP all attenuated the inhibitory effect of PDE1 on relaxation, whereas PKA inhibition with H89 had no effect.Conclusions and ImplicationsPde1a is the dominant PDE1 isoform present in VSMCs, and relaxation mediated by PDE1A inhibition is predominantly driven by enhanced cGMP signalling. These results imply that isoform‐selective PDE1 inhibitors are powerful investigative tools allowing examination of physiological and pathological roles of PDE1 isoforms.
p53‐mediated regulation of bile acid disposition attenuates cholic acid‐induced cholestasis in mice
Authors: Chen Pan , Li Dongshun , Chen Yixin , Sun Jiahong , Fu Kaili , Guan Lihuan , Zhang Huizhen , Jiang Yiming , Li Xi , Zeng Xuezhen , Chen Xiao , Huang Min , Bi Huichang 
Published: September 2017

Background and PurposeThe tumour suppressor p53 is traditionally recognized as a surveillance molecule to preserve genome integrity. Recent studies have demonstrated that it contributes to metabolic diseases. Here, we investigated the role of p53 in the regulation of bile acid disposition and cholestasis.Experimental ApproachThe bile acid disposition‐related gene expression profile affected by p53 activation was assessed in mouse primary hepatocytes with p53 depletion and in Trp53‐null mice. Dual luciferase reporter assay was used to detect the transcriptional activities of target genes. Anticholestatic effects of p53 activator doxorubicin were investigated in a 0.5% cholic acid‐fed mouse model of cholestasis. Changes in bile acids were evaluated using metabolomics analysis.Key ResultsDoxorubicin‐mediated p53 activation induced Cyp2b10, Sult2a1 and Abcc2/3/4 expression in mice in vitro and in vivo. ABCC3 and CYP2B6 (human orthologue of Cyp2b10) were identified as direct p53 target genes. Doxorubicin attenuated cholic acid‐induced cholestasis in mice, as demonstrated by shrunken gall bladder, decreased serum total bile acid and total bilirubin levels and alkaline phosphatase activity. Targeted metabolomics analysis revealed that doxorubicin enhanced the excretion of bile acid metabolites from serum and liver to intestine and faeces. Up‐regulation of Cyp2b10, Sult2a1 and Abcc2/3/4 expression was further confirmed in cholestatic mice. Cholic acid‐induced cholestatic injury was aggravated in p53‐deficient mice and levels of bile acid in intestine and faeces were decreased.Conclusions and ImplicationsOur findings suggest a novel role of p53 in promoting bile acid disposition and alleviating cholestatic syndrome, which provides a potential therapeutic target for cholestasis.
Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells
Authors: Song Lin , Ding Sha , Ge Zhen , Zhu Xiaolong , Qiu Cong , Wang Yuewen , Lai Enyin , Yang Weijun , Sun Yi , Chow Samson A , Yu Luyang 
Published: September 2017

Background and PurposeCardiovascular disease associated with antiretroviral therapy (ART) has become a major clinical challenge for HIV‐positive patients. However, the role of ART in blood vessel growth is largely unknown. Here, we examined an integral component of ART, nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) and investigated their effects on key microvascular functions, including angiogenesis and lymphangiogenesis.Experimental ApproachThe angiogenesis/lymphangiogenesis capability of endothelial cells (ECs) was evaluated using migration, proliferation and tube formation assaysin vitro, and mouse ear and Matrigel plug assaysin vivo. Expressions of signalling molecules and mitochondrial antioxidant catalases were determined using Western blotting. Receptor tyrosine kinase (RTK) internalization and endocytosis were examined using flow cytometry and confocal immunofluorescence microscopy respectively. Mitochondrial DNA copy number and ROS were determined using quantitative real‐time PCR and MitoSOX staining respectively.Key ResultsPharmaceutical doses of NRTIs [azidothymidine (AZT), tenofovir disoproxil fumarate (TDF) and lamivudine (3TC)] inhibited angiogenesis and lymphangiogenesis bothin vivoandin vitroby affecting the proliferation and migration of ECs. Correspondingly, NRTIs selectively attenuated the activation and transduction of endothelial RTK signals, VEGFR2 and FGFR1 pathways, in vascular ECs and the VEGFR3 pathway in lymphatic ECs. Both TDF and 3TC restrained RTKs’ endocytosis into early endosomes but not internalization, while AZT blocked the protein maturation of RTKs. Excessive ROS levels were detected in NRTI‐treated ECs, and the MnSOD mimic MnTMPyP alleviated the angiogenic/lymphangiogenic defects induced by NRTIs.Conclusions and ImplicationsNRTIs negatively regulate angiogenesis and lymphangiogenesis by inducing mitochondrial oxidative stress and subsequently impairing RTK signalling in ECs.Linked ArticlesThis article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visithttp://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc