bluuebunny/crossref_metadata_2025_split huggingface dataset:
INVESTIGATION OF A BLADDER CANCER CLUSTER IN NORTHWESTERN ILLINOIS
Authors: MALLIN KATHERINE 
Published: February 2017

Abstract
Cancer maps from 1950 through 1979 revealed areas of high mortality from bladder cancer for both males and females in several northwestern illinois counties. In order to further explore this excess, a bladder cancer incidence study was conducted in the eight counties comprising this region. Eligible cases were those first diagnosed with bladder cancer between 1978 and 1985. Age adjusted standardized incidence ratios were calculated for each county and for 97 zip codes within these counties. County results revealed no excesses. Zip code results indicated elevated risks in a few areas, but only two zip codes had significantly elevated results. One of these zip codes had a significant excess in males (standardized incidence ratio = 1.5) and females (standardized incidence ratio = 1.9). This excess was primarily confined to one town in this zip code, in which standardized incidence ratios were significantly elevated in males (1.7) and females (2.6). Further investigation revealed that one of four public drinking water wells in this town had been closed due to contamination; two wells were within a half mile (0.8 km) of a landfill site that had ceased operating in 1972. Tests of these two wells revealed traces of trichloroethylene, tetrachloroethylene, and other solvents. Further investigation of this cluster is discussed.
210Pb in Bioenergy Production
Authors: Hedvall R. , Erlandsson B. 
Published: February 2017

Abstract
210Pb is probably one of the major contributors to the radiation dose received by humans from the fumes emitted from the stacks of power plants using fossil fuels or biofuels. As a first step in the estimation of the total radiological impact on humans of radioactive emissions, we have determined 210Pb radioactivity enrichment factors between fuel and ash products and dose equivalents from 210Pb from stack releases to people living in the surroundings. Radioactivity concentrations in ash, peat, wood and other waste products from forests have been determined in 15 district heating plants, located throughout Sweden, which use bioenergy for hot water production. Dose equivalents to people living close to the plants will be, at most, around a few tens of nSv per year from 210Pb, assuming 1000 Bq.kg-1 in the stack effluent. It was also found that more than 50% of the lead is probably in a volatilised phase, separate from the fly ash, and is therefore not caught in the filters.
Oncogenic Transformation Through the Cell Cycle and the LET Dependent Inverse Dose Rate Effect
Authors: Geard C.R. , Miller R.C. , Brenner D.J. , Hall E.J. 
Published: February 2017

Abstract
Synchronised populations of mouse C3H/10T-1/2 cells were obtained by a stringent mitotic dislodgement procedure. Mitotic cells rapidly attach and progress sequentially through the cell cycle. Irradiation (3 Gy of X rays) was carried out at intervals from 0 to 18 h after initiating cell cycle progression of the mitotic cells. Oncogenic transformation was enhanced 10-fold over cells irradiated soon after replating (G1 and S phases) for cells in a near 2 h period corresponding to cells in G2 phase but not in mitosis. The cell surviving fraction has a 2-1/2-fold variation with resistant peaks corresponding to the late G1 and late S phases. These findings provide experimental support for the hypothesis initiated by Rossi and Kellerer and developed by Brenner and Hall to explain the LET dependent inverse dose rate effect for oncogenic transformation.
Greening the black box: integrating the environment and management control systems
Authors: Sundin Heidi , Brown David Andrew 
Published: February 2017

Purpose
The purpose of this paper is to adopt an agency theory approach to investigate the integration of environmental issues into management control systems (MCS). Prior environmental accounting research has focussed on increasing organisations’ environmental accountability by “monitoring” through external reporting to stakeholders. However, this overlooks the alignment of agents’ interests within the firm.

Design/methodology/approach
A qualitative case study is undertaken in a large Australian listed property trust to investigate how agents’ interests may be integrated with environmental objectives through the use of MCS.

Findings
From the case an analytical framework is developed to illustrate how environmental issues are incorporated into organisational behaviour through MCS. The findings include, single objective environmental MCS; multiple objective MCS, which include priorities that specify environmental and economic trade-offs; and balancing MCS, which provide overarching decision-making principles without priorities.

Practical implications
The findings provide examples of how an organisation may integrate environmental issues across a range of MCS and the things to consider in doing so.

Originality/value
This paper draws on an agency perspective as an approach to incorporate environmental issues into MCS and to align behaviour. It explains a new way in which tensions can be managed. This study is one of the first to adopt the control package approach in investigating the incorporation of environmental issues in MCS.
Intertextuality in corporate narratives: a discursive analysis of a contested privatization
Authors: Lupu Ioana , Sandu Raluca 
Published: February 2017

Purpose
Despite the growing amount of research on the social and organizational role of legitimacy, very little is known about the subtle discursive processes through which organizational changes are legitimated in contemporary society. The purpose of this paper is to explore the subtle processes of interdiscursivity and intertextuality through which an organization constructs a sense of legitimacy.

Design/methodology/approach
Drawing on the case of a newly privatized oil company in a transitional, post-communist economy, the authors’ research uses critical discourse analysis to analyze the annual reports, corporate press releases, and relevant media from the four years following privatization.

Findings
The authors argue for a relational understanding of legitimacy construction that emphasizes how legitimacy relies on the multiple processes of intertextuality linking corporate narratives and media texts. Corporate narratives are not produced solely by the discourses that occur at the individual and organizational levels; they are also produced by the much broader discourses that occur at the societal level.

Originality/value
This study’s main contribution is that it reveals the intertextual and interdiscursive construction of corporate narratives, which is a key element in understanding how discourses around privatization are interlinked and draw upon other macro-level discourses to construct legitimacy.
Implementing the balanced scorecard in a local government sport organization
Authors: Dimitropoulos Panagiotis , Kosmas Ioannis , Douvis Ioannis 
Published: February 2017

Purpose
The purpose of this paper is to examine the issue of performance management in the public sector and specifically the implementation of the balanced scorecard (BSC) methodology on a public (municipal) non-profit sport organization in Greece. The research provides a discussion on the BSC development process, the goals set on each pillar and the outcome that the organization achieved, in order to be used as a roadmap for other managers in the public sector.

Design/methodology/approach
The study used information extracted from the municipal board of Papagos-Holargos city in Greece, including board reports, documents and decision transcripts and open-ended interviews related to the implementation of BSC method, as well as to the impact of this decision on the quality of services, citizens’ satisfaction and the improvement of internal processes.

Findings
The results indicated that the citizens of Papagos-Holargos perceived sport services to be of enhanced quality related to/when compared to the previous years (based on a questionnaire submitted by the citizens of Papagos-Holargos at the end of the each sample per year). In addition, the staff improved its skills and abilities by participating in training seminars and, in general, the implementation of the BSC method on the municipal sport organization of Papagos-Holargos city sets the basis for an effective performance management which can enhance its future sustainability.

Practical implications
Managers of municipal and public sport organizations could use the findings of the study as a roadmap for discussing, evaluating and possibly implementing the BSC approach in their organizations’ daily operations.

Originality/value
This study fills a significant gap in the existing literature on the implementation of a traditional business performance management tool on a non-profit public sport organization.
Sustainable business strategies: typologies and future directions
Authors: Gauthier Jeffrey 
Published: February 2017

PurposeThe purpose of this paper is to develop a typology of sustainable business strategies that may help to guide future empirical research.Design/methodology/approachThe approach involves a review of prior typologies and an application of the resource-based view of the firm to identify the resources and capabilities associated with each strategy.FindingsResearch propositions concerning the relationship between implementation of each strategy and requisite capabilities are offered.Research limitations/implicationsThe research propositions developed in the paper offer a means to catalyze future empirical research at the intersection of strategy and sustainability.Originality/valueBarriers to understanding the capabilities necessary to implement sustainability strategies render sustainable development an elusive goal. This paper helps to advance this understanding, identifying the primary capabilities needed to implement distinct sustainability strategies.
A novel VWF variant associated with type 2 von Willebrand disease in German Wirehaired Pointers and German Shorthaired Pointers
Authors: Vos‐Loohuis M. , van Oost B. A. , Dangel C. , Langbein‐Detsch I. , Leegwater P. A. 
Published: February 2017

SummaryVon Willebrand disease (VWD), caused by deficiency of the von Willebrand factor (VWF), is the most common bleeding disorder in humans and dogs. The complete cDNA encoding VWF of a German Wirehaired Pointer with type 2 VWD was sequenced, and we found four variants that alter the amino acid sequence. These variants were: c.1657T>G corresponding to p.Trp553Gly; c.1777G>A (p.Glu593Lys); c.4937A>G (p.Asn1646Ser) and c.5544G>A (p.Met1848Ile). A haplotype of the c.1657G, c.1777A and c.4937G alleles co‐segregated with the VWF antigen level in a four‐generation pedigree with the disease. Healthy dogs of the breed were found that were homozygous for the c.1777A or the c.5544A allele, indicating that these variants do not cause VWD. Dogs that were homozygous for the c.4937G allele and had no signs of a bleeding disorder were observed in the Chinese Crested dog breed. Thus, only the c.1657G variant was found in the homozygous state exclusively in VWD affecteds, and this variant is the strongest candidate to be the cause of VWD type 2 in the German Wirehaired Pointer breed. A screen of German Shorthaired Pointers indicated that the variant also segregates with VWD in this breed.
Life satisfaction of older Turks living in Australia
Authors: Öztop Hülya , Kınacı Bahar 
Published: February 2017

ObjectiveThis study examined the influence of socio‐economic and demographic variables, the frequency of travel to Turkey and years of living in Sydney on the life satisfaction of older Turkish people.MethodsThis study was conducted with 110 participants of 60 years of age or older, at the New South Wales Turkish Welfare Association in Sydney, Australia. The surveys were administered face‐to‐face at a date and time these participants went to the Association. The dependent variable of the study was the Life Satisfaction Scale. The study data were analysed using hierarchical regression analysis, and the three sets of regression models were run for each sex.ResultsThe research found that in addition to sociodemographic factors, frequency of travel to Turkey, particularly for older women, and their years of living in Sydney had negative effects on life satisfaction. The study results indicate that the frequency of both the male and female participants’ visits to Turkey had a strong negative influence on their life satisfaction. Life satisfaction decreased as the frequency of the participants’ visits to Turkey and years of living in Sydney increased.ConclusionThese findings support the current literature that shows the effects of the frequency of travel to Turkey and years of living in Sydney, which were considered to influence relationships with social networks, on life satisfaction, and indicates the necessity for a more detailed examination of social network relationships.
Epistemic Authority and Genuine Ethical Controversies
Authors: Roberts Adam James 
Published: February 2017

AbstractIn ‘Professional Hubris and its Consequences’, Eric Vogelstein claims that ‘that there are no good arguments in favor of professional organizations taking genuinely controversial positions on issues of professional ethics’. In this response, I defend two arguments in favour of organisations taking such positions: that their stance‐taking may lead to better public policy, and that it may lead to better practice by medical professionals. If either of those defences succeeds, then Vogelstein's easy path to his conclusion – that professional organisations should not take such stances – is blocked. He or others must instead look to establish that the reasons against stance‐taking on genuine ethical controversies are more compelling than those for it: plausibly a more challenging task.
Socio‐demographic factors relating to perception and use of mobile technologies in tertiary teaching
Authors: Lai Kwok‐Wing , Smith Lee 
Published: February 2017

AbstractIn 2014, we investigated how socio‐demographic factors such as gender, teaching disciplines, teaching experience and academic seniority were related to the perception and use of digital mobile technologies in learning and teaching of a group of university teachers from one research‐intensive university in New Zealand. Three hundred and eight teachers from this university completed an online questionnaire and 30 of them participated in a follow‐up interview. Survey results showed that while there was a strong positive correlation between using mobile technologies for personal learning and their use in teaching, only a small number of participants utilised mobile technologies in their learning and the vast majority also did not use these technologies in their teaching, More female teachers and humanities teachers used mobile devices and applications more frequently than male teachers and teachers from other academic disciplines. Also, female teachers had a more positive perception in learning and using mobile technologies. Junior teachers also tended to be more positive in technology use. While the overwhelming majority of the interview participants also perceived positive benefits of incorporating mobile devices and applications into their teaching, it was found that female teachers paid greater attention to pedagogy when considering mobile technology use and the lack of professional development limited their use in teaching.
Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men
Authors: Eendebak Robert J.A.H. , Swiecicka Agnieszka , Gromski Piotr S. , Pye Stephen R. , O'Neill Terence W. , Marshall Alan , Keevil Brian G. , Tampubolon Gindo , Goodacre Royston , Wu Frederick C.W. , Rutter Martin K. 
Published: February 2017

SummaryObjectivesTo assess ethnic differences in male reproductive hormone levels and to determine whether any differences are explained by adiposity, insulin resistance (IR) or comorbidities in older men.DesignMulti‐ethnic cross‐sectional observational study.ParticipantsCommunity dwelling middle‐aged and elderly men residing in the UK aged 40–84 years of South Asian (SA; n = 180), White European (WE; n = 328) or African Caribbean (AC; n = 166) origin.ObservationsMeasured testosterone (T), calculated free T (cFT), sex hormone‐binding globulin and LH in SA, WE and AC men along with an assessment of body composition, IR, lifestyle factors and medical conditions.ResultsAge‐adjusted mean T and cFT levels were lower in SA men when compared to WE and AC men (mean (SEM) T: SA: 14·0 ± 0·4; WE: 17·1 ± 0·3; AC: 17·2 ± 0·5 nmol/l, P < 0·001; cFT: SA: 283 ± 7; WE: 313 ± 5; AC: 314 ± 8 pmol/l, P < 0·006). Compared to WE and AC men, SA men had higher levels of body fat, IR, comorbidities and diabetes. After adjusting for body fat, IR and other confounders, T levels in SA men remained lower than in WE men (P = 0·04) but ethnic differences in cFT became nonsignificant. LH levels were higher in SA than WE men in age‐adjusted and fully adjusted models.ConclusionsT and cFT are lower in SA men than in WE and AC men. Whether ethnic‐specific reference ranges for T and cFT might be appropriate in clinical practice requires further investigation. Ethnic differences in cFT, but not T, appear to be, more readily, explained by ethnic differences in adiposity, thus providing insights into potential pathophysiological mechanisms.
Histopathological analysis of cold snare polypectomy and its indication for colorectal polyps 10–14 mm in diameter
Authors: Hirose Ryohei , Yoshida Naohisa , Murakami Takaaki , Ogiso Kiyoshi , Inada Yutaka , Dohi Osamu , Okayama Tetsuya , Kamada Kazuhiro , Uchiyama Kazuhiko , Handa Osamu , Ishikawa Takeshi , Konishi Hideyuki , Naito Yuji , Fujita Yasuko , Kishimoto Mitsuo , Yanagisawa Akio , Itoh Yoshito 
Published: February 2017

Background and AimCold snare polypectomy (CSP) is commonly used for treating colorectal polyps <10 mm in diameter. We evaluated the analysis and safety of CSP for larger polyps.MethodsWe retrospectively analyzed 1006 colorectal polyps resected with CSP. Indication for CSP was polyps 2–14 mm that were diagnosed as benign neoplastic polyp by magnifying endoscopy. Various clinicopathological characteristics were analyzed. Multivariate analyses were used to determine the independent risk factors for failure of complete CSP resection. With respect to polyp size, we compared the therapeutic outcomes between polyps <10 mm and ≥10 mm. Additionally, the presence of muscularis mucosa in resected specimens was analyzed.ResultsRates of en bloc resection and postoperative hemorrhage were 98.8% and 0.1%, respectively. Seven hundred and ninety‐one neoplastic lesions were analyzed and negative margins were found in 70.5% of the lesions, Multivariate analysis showed that non‐polypoid morphology, histology of intramucosal cancer + high‐grade adenoma and sessile serrated adenoma and polyp were significant factors for incomplete resection. With respect to the difference between lesions ≥10 mm than in those <10 mm, rates of cancer and positive/unclear margins were significantly higher (5.0% vs 0.9%, P < 0.001; 40.6% vs 27.7%, P = 0.007) in the ≥10 mm with rates of postoperative hemorrhage not significantly different (0.8% vs 0.0%). Additionally, the loss of muscularis mucosa was found in 27.8% of all lesions.ConclusionCSP is a safe procedure for polyps 2–14 mm. However, CSP has limitations in terms of the histopathological margin and loss of muscularis mucosa in specimens.
Zinc rescues obesity‐induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress‐activated BCL10/CARD9/p38 MAPK pathway
Authors: Wang Shudong , Gu Junlian , Xu Zheng , Zhang Zhiguo , Bai Tao , Xu Jianxiang , Cai Jun , Barnes Gregory , Liu Qiu‐Ju , Freedman Jonathan H. , Wang Yonggang , Liu Quan , Zheng Yang , Cai Lu 
Published: February 2017

AbstractObesity often leads to obesity‐related cardiac hypertrophy (ORCH), which is suppressed by zinc‐induced inactivation of p38 mitogen‐activated protein kinase (p38 MAPK). In this study, we investigated the mechanisms by which zinc inactivates p38 MAPK to prevent ORCH.Mice (4‐week old) were fed either high fat diet (HFD, 60% kcal fat) or normal diet (ND, 10% kcal fat) containing variable amounts of zinc (deficiency, normal and supplement) for 3 and 6 months. P38 MAPK siRNA and the p38 MAPK inhibitor SB203580 were used to suppress p38 MAPK activity in vitro and in vivo, respectively. HFD activated p38 MAPK and increased expression of B‐cell lymphoma/CLL 10 (BCL10) and caspase recruitment domain family member 9 (CARD9). These responses were enhanced by zinc deficiency and attenuated by zinc supplement. Administration of SB203580 to HFD mice or specific siRNA in palmitate‐treated cardiomyocytes eliminated the HFD and zinc deficiency activation of p38 MAPK, but did not significantly impact the expression of BCL10 and CARD9. In cultured cardiomyocytes, inhibition of BCL10 expression by siRNA prevented palmitate‐induced increased p38 MAPK activation and atrial natriuretic peptide (ANP) expression. In contrast, inhibition of p38 MAPK prevented ANP expression, but did not affect BCL10 expression. Deletion of metallothionein abolished the protective effect of zinc on palmitate‐induced up‐regulation of BCL10 and phospho‐p38 MAPK. HFD and zinc deficiency synergistically induce ORCH by increasing oxidative stress‐mediated activation of BCL10/CARD9/p38 MAPK signalling. Zinc supplement ameliorates ORCH through activation of metallothionein to repress oxidative stress‐activated BCL10 expression and p38 MAPK activation.
Biochemical proximates of pumpkin (Cucurbitaeae spp.) and their beneficial effects on the general well‐being of poultry species
Authors: Achilonu M. C. , Nwafor I. C. , Umesiobi D. O. , Sedibe M. M. 
Published: February 2017

SummaryThere is a growing need to increase productivity in poultry. Growth hormones and antibiotics have the ability to improve health, weight gain and feed efficiency in meat‐producing animals. The growth‐promoting antibiotics are administered to poultry to improve the general performance of the chicken. However, the use of the xenobiotic drugs in food‐producing animals has been a concern and a sensitive issue of debate for several decades in the EU and many other regional blocks of the world. Consequently, the use of hormones in animal production has been banned in Italy, Denmark and Germany for over 4–5 decades, while Belgium and Greece had never permitted its use for livestock fattening purposes. Bioactive phytochemicals exhibit antimicrobial, antioxidant, antiparasitic, antiprotozoal, antifungal and anti‐inflammatory properties and consequently have several beneficial effects on appetite, growth and the immune status of the animal. In South Africa, different species of pumpkin are produced for food due to their high nutrient content. The flesh serves as a traditional food, while the seeds and peels are commonly discarded. Pumpkin seed extract is reported to be useful for immunomodulation, reproductive health, therapeutics over a wide range of disease conditions and stimulates metabolism of accumulated fats. Studies have also shown that pumpkin seeds are a valuable source of protein and fat. Their complexity and extent of bioactivity offers sustainable prospects for natural control of pathogenic/parasitic organisms, stimulate nutrition or enhance resistance to disease infections, and reduce abdominal fat and serum levels of harmful lipids, while increasing serum levels of beneficial lipids.