bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arts-based HIV and STI prevention intervention with Northern and Indigenous youth in the Northwest Territories: study protocol for a non-randomised cohort pilot study
Authors: Lys Candice , Logie Carmen H , MacNeill Nancy , Loppie Charlotte , Dias Lisa V , Masching Renée , Gesink Dionne 
Published: October 2016

IntroductionIndigenous youth are disproportionately represented in new HIV infection rates in Canada. Current and historical contexts of colonisation and racism, disconnection from culture and land, as well as intergenerational trauma resulting from the legacy of residential schools are social drivers that elevate exposure to HIV among Indigenous peoples. Peer-education and arts-based interventions are increasingly used for HIV prevention with youth. Yet limited studies have evaluated longitudinal effects of arts-based approaches to HIV prevention with youth. The authors present a rationale and study protocol for an arts-based HIV prevention intervention with Northern and Indigenous youth in the Northwest Territories (NWT), Canada.Methods and analysisThis is a multicentre non-randomised cohort pilot study using a pretest/post-test design with a 12-month follow-up. The target population is Northern and Indigenous youth in 18 communities in the NWT. The aim is to recruit 150 youth using venue-based sampling at secondary schools. Participants will be involved in an arts-based intervention, Fostering Open eXpression among Youth (FOXY). Participants will complete a pretest, post-test survey directly following the intervention, and a 12-month follow-up. The primary outcome is new or enhanced HIV knowledge, and secondary outcomes to include: new or enhanced sexually transmitted infections knowledge, and increased self-esteem, resilience, empowerment, safer sex self-efficacy and cultural connectedness. Mixed effects regression analyses will be conducted to evaluate pretest and post-test differences in outcome measurement scores.Ethics and disseminationThis study has received approval from the HIV Research Ethics Board at the University of Toronto (REB: 31602). In addition, the project is currently registered in the NWT with the Aurora Research Institute (Licence: 15741). Trial results will be published according to the Transparent Reporting of Evaluations with Nonrandomised Designs statement.Trial registration numberNCT02743026; Pre-results.
Systematic review protocol assessing the processes for linking clinical trial registries and their published results
Authors: Bashir Rabia , Dunn Adam G 
Published: October 2016

IntroductionClinical trial registries are an important source of information for tracking clinical trials from their inception through to their reporting, and have been used to measure publication bias and outcome reporting bias. Our aim is to survey and quantify the processes that have been used to identify links between clinical trial registries and published trial reports in studies that rely on these links to evaluate the completeness and accuracy of trial reporting.Methods and analysisWe will identify studies that describe a process for identifying the links between a trial registry included in the WHO International Clinical Trial Registry Platform and published trial results, and use those links to evaluate the completeness and accuracy of trial reporting. Information extracted from the studies will include the purpose and application domain of the study, registries used or searched, processes by which the links were identified, the study period and proportions for which links were found. We will summarise what is known about the number and availability of links between clinical trial registries and published results, and examine how automatic linking, inference and inquiry processes have been used to identify links since the introduction of trial registries.Ethics and disseminationThe systematic review is focused on the analysis of secondary data and does not require ethics approval. The results of the systematic review will be used to inform standard processes used to identify links to and from clinical trial registries in studies that evaluate the completeness and accuracy of clinical trial reports, as well as systematic reviews. Our findings will be disseminated by publishing the systematic review in a peer-reviewed journal, and by engaging with stakeholders from clinical trial registries and bibliographic databases.
Fructose intake and risk of gout and hyperuricemia: a systematic review and meta-analysis of prospective cohort studies
Authors: Jamnik Joseph , Rehman Sara , Blanco Mejia Sonia , de Souza Russell J , Khan Tauseef A , Leiter Lawrence A , Wolever Thomas M S , Kendall Cyril W C , Jenkins David J A , Sievenpiper John L 
Published: October 2016

BackgroundThe prevalence of hyperuricemia and gout has increased in recent decades. The role of dietary fructose in the development of these conditions remains unclear.ObjectiveTo conduct a systematic review and meta-analysis of prospective cohort studies investigating the association fructose consumption with incident gout and hyperuricemia.DesignMEDLINE, EMBASE and the Cochrane Library were searched (through September 2015). We included prospective cohort studies that assessed fructose consumption and incident gout or hyperuricemia. 2 independent reviewers extracted relevant data and assessed study quality using the Newcastle-Ottawa Scale. We pooled natural-log transformed risk ratios (RRs) using the generic inverse variance method. Interstudy heterogeneity was assessed (Cochran Q statistic) and quantified (I2statistic). The overall quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.Results2 studies involving 125 299 participants and 1533 cases of incident gout assessed the association between fructose consumption and incident gout over an average of 17 years of follow-up. No eligible studies assessed incident hyperuricemia as an outcome. Fructose consumption was associated with an increase in the risk of gout (RR=1.62, 95% CI 1.28 to 2.03, p<0.0001) with no evidence of interstudy heterogeneity (I2=0%, p=0.33) when comparing the highest (>11.8% to >11.9% total energy) and lowest (<6.9% to <7.5% total energy) quantiles of consumption.LimitationsDespite a dose–response gradient, the overall quality of evidence as assessed by GRADE was low, due to indirectness. There were only two prospective cohort studies involving predominantly white health professionals that assessed incident gout, and none assessed hyperuricemia.ConclusionsFructose consumption was associated with an increased risk of developing gout in predominantly white health professionals. More prospective studies are necessary to understand better the role of fructose and its food sources in the development of gout and hyperuricemia.Protocol registration numberNCT01608620.
A new index for the assessment of transverse sinus stenosis for diagnosing idiopathic intracranial hypertension
Authors: Carvalho Gustavo Balthazar da Silveira , Matas Sandro Luiz de Andrade , Idagawa Marcos Hideki , Tibana Luiz Antônio Tobaru , de Carvalho Renato Sartori , Silva Matheus Luis Souza , Cogo-Moreira Hugo , Jackowski Andrea Parolin , Abdala Nitamar 
Published: October 2016

Background and purposeTo assess the role of MR venography (MRV) for detecting transverse sinus stenosis, to determine the importance of this finding in idiopathic intracranial hypertension (IIH), and to propose an index that contributes to this diagnosis.Materials and methodsWe retrospectively assessed consecutive intracranial MRV of patients aged >18 years diagnosed with IIH according to the diagnostic criteria, between January 2010 and July 2012. The assessments were randomly analyzed by three radiologists. Stenoses in the right and left transverse sinuses were independently classified according to the following scale: 0, normal; 1, stenosis <33%; 2, stenosis 33–66%; 3, stenosis >66%; and 4, hypoplasia or agenesis. We established an index based on multiplication of the stenosis scale values for each transverse sinus. A point and range estimate of the sensitivity, specificity, and the area under the receiver operating characteristic curve was performed to obtain cut-off points to differentiate between controls and patients.Results63 individuals were included in this study: 32 (50.8%) diagnosed with IIH (31 (96.9%) women and 1 (3.1%) man) and 31 (49.2%) controls. According to all of the examiners, the IIH group showed a higher degree of stenosis than the control group. Index values ≥4 for a diagnosis of IIH had a sensitivity and specificity of 94.7% and 93.5%, respectively.ConclusionsMRV should be used to assess patients with suspected IIH, and bilateral transverse sinus stenosis should be considered for the diagnosis. The stenosis classifying index proposed here is a fast and accessible method for diagnosing IIH.
Stent-assisted coiling of cerebrovascular aneurysms: experience at a large tertiary care center with a focus on predictors of recurrence
Authors: Linzey Joseph R , Griauzde Julius , Guan Zhe , Bentley Nicole , Gemmete Joseph J , Chaudhary Neeraj , Thompson B Gregory , Pandey Aditya S 
Published: October 2016

BackgroundStent-assisted coiling is commonly used to treat wide-necked and fusiform cerebral aneurysms. We evaluated our institutional experience with stent-assisted coiling of cerebral aneurysms to elucidate potential risk factors for recurrence.MethodsA retrospective analysis of patients undergoing stent-assisted coiling of cerebral aneurysms from 2005 to 2012 resulted in 122 patients with 122 aneurysms. Demographic, peri-procedural, medical comorbidity, and follow-up data were collected. Primary outcomes of interest were procedural safety, efficacy, and aneurysm recurrence. Univariate and multivariate logistic regression and χ2tests determined the statistical significance of the risk factors.ResultsAll 122 stent-assisted coiling procedures led to satisfactory obliteration of the aneurysm (3.3% complication rate). Twenty-one (17.2%) patients experienced recurrence at average follow-up of 297 days. Fifteen (71.4%) clinically significant recurrences required retreatment. Eleven of 30 (36.7%) procedures using Enterprise stents had recurrence compared with only 10 of 92 (10.9%) procedures using Neuroform stents (p=0.001). Average coiling packing density (PD) was 20.3% with Enterprise stents and 22.5% with Neuroform stents (p=0.8). In multivariate logistic regression, recurrences requiring recoiling were significantly associated with Enterprise stents (OR 8.57, 95% CI 1.97 to 37.19; p=0.004), females (OR 0.19, 95% CI 0.04 to 1.00; p=0.05), and postoperative dextran use (OR 8.42, 95% CI 1.40 to 50.58; p=0.02). Aneurysms with <20% PD were more likely to have a clinically significant recurrence than aneurysms with >20% PD (19% vs 5.1%; p=0.02).ConclusionsStent-assisted coiling for wide-necked cerebral aneurysms has a high therapeutic success rate with low procedure-related morbidity and mortality. Clinically significant recurrences may occur more frequently with Enterprise stents, in aneurysms with low PD, and with post-procedural dextran use.
Assessment of Total Lesion Glycolysis by 18F FDG PET/CT Significantly Improves Prognostic Value of GEP and ISS in Myeloma
Authors: McDonald James E. , Kessler Marcus M. , Gardner Michael W. , Buros Amy F. , Ntambi James A. , Waheed Sarah , van Rhee Frits , Zangari Maurizio , Heuck Christoph J. , Petty Nathan , Schinke Carolina , Thanendrarajan Sharmilan , Mitchell Alan , Hoering Antje , Barlogie Bart , Morgan Gareth J. , Davies Faith E. 
Published: October 2016

Abstract
Purpose: Fluorine-18 fluorodeoxyglucose positron emission tomography with CT attenuation correction (18F-FDG PET/CT) is useful in the detection and enumeration of focal lesions and in semiquantitative characterization of metabolic activity (glycolytic phenotype) by calculation of glucose uptake. Total lesion glycolysis (TLG) and metabolic tumor volume (MTV) have the potential to improve the value of this approach and enhance the prognostic value of disease burden measures. This study aims to determine whether TLG and MTV are associated with progression-free survival (PFS) and overall survival (OS), and whether they improve risk assessments such as International Staging System (ISS) stage and GEP70 risk.
Experimental Design: 192 patients underwent whole body PET/CT in the Total Therapy 3A (TT3A) trial and were evaluated using three-dimensional region-of-interest analysis with TLG, MTV, and standard measurement parameters derived for all focal lesions with peak SUV above the background red marrow signal.
Results: In multivariate analysis, baseline TLG &gt; 620 g and MTV &gt; 210 cm3 remained a significant factor of poor PFS and OS after adjusting for baseline myeloma variables. Combined with the GEP70 risk score, TLG &gt; 205 g identifies a high-risk–behaving subgroup with poor expected survival. In addition, TLG &gt; 205 g accurately divides ISS stage II patients into two subgroups with similar outcomes to ISS stage I and ISS stage III, respectively.
Conclusions: TLG and MTV have significant survival implications at baseline and offer a more precise quantitation of the glycolytic phenotype of active disease. These measures can be assessed more readily than before using FDA-approved software and should be standardized and incorporated into clinical trials moving forward. Clin Cancer Res; 23(8); 1981–7. ©2016 AACR.
Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Authors: Abdollahi Pegah , Vandsemb Esten N. , Hjort Magnus A. , Misund Kristine , Holien Toril , Sponaas Anne-Marit , Rø Torstein B. , Slørdahl Tobias S. , Børset Magne 
Published: October 2016

AbstractPhosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual-specificity phosphatase that is upregulated in various types of cancers and is related to poor prognosis and aggressive tumor behavior. The expression level of PRL-3 is elevated in response to several antiapoptotic cytokines, including IL6, in cancer cells from patients with multiple myeloma (MM) and can promote survival and migration. Here, it is demonstrated that PRL-3 activates Src kinase in the IL6-dependent MM cell line INA-6. Inhibition of PRL-3 by a small-molecule inhibitor of PRL-3 or by shRNA resulted in inactivation of Src. In addition to activation of Src, PRL-3 also activated the Src family kinase (SFK) members LYN and HCK in INA-6 cells. Forced expression of catalytically inactive mutant PRL-3 decreased the activation of these three SFK members while the total level of HCK and FYN remained elevated. Inhibitors of Src increased sensitivity of cells overexpressing PRL-3 to the PRL-3 inhibitor through joint downregulation of both PRL-3 and Mcl-1. In conclusion, PRL-3 protected MM cells against apoptosis by dysregulating both the total levels and the activation levels of specific SFK members that are important for IL6 signal transduction in MM cells. Eventually, this led to increased levels of Mcl-1.Implications: This study suggests PRL-3 and SFKs are key mediators of the IL6-driven signaling events and points to both PRL-3 and SFK members as potential targets for treatment of MM. Mol Cancer Res; 15(1); 69–77. ©2016 AACR.
SAFIR-3000 Lightning Statistics over the Beijing Metropolitan Region during 2005–07
Authors: Wu Fan , Cui Xiaopeng , Zhang Da-Lin , Liu Dongxia , Zheng Dong 
Published: October 2016

AbstractIn this study, the spatiotemporal characteristics of cloud-to-ground (CG) and intracloud (IC) lightning flashes observed by Surveillance et Alerte Foudre par Interférometrie Radioélectrique (SAFIR)-3000 over the Beijing metropolitan region (BMR) during 2005–07 were investigated. The results showed the presence of 299 lightning days with 241 688 flashes, most of which were IC lightning flashes. Only 19% of the total flashes were CG lightning flashes; 14% of these CG flashes were positive. Most lightning activity occurred during the summer months (June–August), with a major diurnal peak around 1900 Beijing standard time (BST) and a secondary peak around 2300 BST. Spatial variations in flash density and lightning days both exhibited an obvious southeastwardly increasing pattern, with higher flash densities or more lightning days occurring in the southeastern plains and lower values distributed on the northwestern mountains. TheZratio (IC/CG lightning flashes) exhibited a similar spatial pattern, but the percentage of positive CG lightning flashes showed an almost opposite pattern. The results also showed significant topographic effects on the spatiotemporal variations in lightning activity. That is, flash counts on the northeastern and southwestern mountains peaked in the afternoon, whereas those on the southeastern plains peaked in the late night to early morning, which could be attributed to the propagation of thunderstorms from the mountains to the plains. The results showed that the SAFIR-3000 lightning data are more useful than CG lightning data alone for forecasting the development and propagation of thunderstorms over the BMR.
Public Perception of Quality and Support for Required Access to Drinking Water in Schools and Parks
Authors: Long Michael W. , Gortmaker Steven L. , Patel Anisha I. , Onufrak Stephen J. , Wilking Cara L. , Cradock Angie L. 
Published: October 2016

Purpose: We assessed public support for required water access in schools and parks and perceived safety and taste of water in these settings to inform efforts to increase access to and consumption of tap water. Design: Cross-sectional survey of the US public collected from August to November 2011. Setting: Random digit-dialed telephone survey. Participants: Participants (n = 1218) aged 17 and older from 1055 US counties in 46 states. Measures: Perceived safety and taste of water in schools and parks as well as support for required access to water in these settings. Analysis: Survey-adjusted perceived safety and taste as well as support for required access were estimated. Results: There was broad support for required access to water throughout the day in schools (96%) and parks (89%). Few participants believed water was unsafe in schools (10%) or parks (18%). Conclusion: This study provides evidence of public support for efforts to increase access to drinking water in schools and parks and documents overall high levels of perceived taste and safety of water provided in these settings.
CT-angiography source images indicate less fatal outcome despite coma of patients in the Basilar Artery International Cooperation Study
Authors: Pallesen Lars P , Khomenko Andrei , Dzialowski Imanuel , Barlinn Jessica , Barlinn Kristian , Zerna Charlotte , van der Hoeven Erik JRJ , Algra Ale , Kapelle L Jaap , Michel Patrik , Bodechtel Ulf , Demchuk Andrew M , Schonewille Wouter , Puetz Volker ,   on behalf of the BASICS-Study group
Published: October 2016

Background Coma is associated with poor outcome in patients with basilar artery occlusion. Aims We sought to assess whether the posterior circulation Acute Stroke Prognosis Early CT Score and the Pons-Midbrain Index applied to CT angiography source images predict the outcome of comatose patients in the Basilar Artery International Cooperation Study. Methods Basilar Artery International Cooperation Study was a prospective, observational registry of patients with acute basilar artery occlusion with 48 recruiting centers worldwide. We applied posterior circulation Acute Stroke Prognosis Early CT Score and Pons-Midbrain Index to CT angiography source images of Basilar Artery International Cooperation Study patients who presented with coma. We calculated adjusted risk ratios to assess the association of dichotomized posterior circulation Acute Stroke Prognosis Early CT Score (≥8 vs. <8) and Pons-Midbrain Index (<3 vs. ≥3) with mortality and favourable outcome (modified Rankin Scale score 0–3) at one month. Results Of 619 patients in the Basilar Artery International Cooperation Study registry, CT angiography source images were available for review in 158 patients. Among these, 78 patients (49%) presented with coma. Compared to non-comatose patients, comatose patients were more likely to die (risk ratios 2.34; CI 95% 1.56–3.52) and less likely to have a favourable outcome (risk ratios 0.44; CI 95% 0.24–0.80). Among comatose patients, a Pons-Midbrain Index < 3 was related to reduced mortality (adjusted RR 0.66; 95% CI 0.46–0.96), but not to favourable outcome (adjusted RR 1.19; 95% CI 0.39–3.62). Posterior circulation Acute Stroke Prognosis Early CT Score dichotomized at ≥ 8 vs. <8 was not significantly associated with death (adjusted RR 0.70; 95% CI 0.46–1.05). Conclusion In comatose patients with basilar artery occlusion, the extent of brainstem ischemia appears to be related to mortality but not to favourable outcome.
Posterior Shoulder Instability
Authors: Antosh Ivan J. , Tokish John M. , Owens Brett D. 
Published: October 2016

Context: Posterior shoulder instability has become more frequently recognized and treated as a unique subset of shoulder instability, especially in the military. Posterior shoulder pathology may be more difficult to accurately diagnose than its anterior counterpart, and commonly, patients present with complaints of pain rather than instability. “Posterior instability” may encompass both dislocation and subluxation, and the most common presentation is recurrent posterior subluxation. Arthroscopic and open treatment techniques have improved as understanding of posterior shoulder instability has evolved. Evidence Acquisition: Electronic databases including PubMed and MEDLINE were queried for articles relating to posterior shoulder instability. Study Design: Clinical review. Level of Evidence: Level 4. Results: In low-demand patients, nonoperative treatment of posterior shoulder instability should be considered a first line of treatment and is typically successful. Conservative treatment, however, is commonly unsuccessful in active patients, such as military members. Those patients with persistent shoulder pain, instability, or functional limitations after a trial of conservative treatment may be considered surgical candidates. Arthroscopic posterior shoulder stabilization has demonstrated excellent clinical outcomes, high patient satisfaction, and low complication rates. Advanced techniques may be required in select cases to address bone loss, glenoid dysplasia, or revision. Conclusion: Posterior instability represents about 10% of shoulder instability and has become increasingly recognized and treated in military members. Nonoperative treatment is commonly unsuccessful in active patients, and surgical stabilization can be considered in patients who do not respond. Isolated posterior labral repairs constitute up to 24% of operatively treated labral repairs in a military population. Arthroscopic posterior stabilization is typically considered as first-line surgical treatment, while open techniques may be required in complex or revision settings.
Cementless Total Hip Arthroplasty Using the Omnifit System: An 8.2 Year Follow-up Study of 166 Hips
Authors: Hsieh Pang-Hsin , Shih Chun-Hsiung , Lee Po-Cheng , Yang Wen-E , Lee Zhon-Liau 
Published: October 2016

One hundred and sixty-six cementless primary total hip arthroplasties were performed in 133 patients with porous coated Omnifit prosthesis. The average age was 49.7 years. The mean follow-up period was 8.2 years with a minimum of 5 years. Good to excellent clinical results were achieved in 93% of patients. The overall revision rate was 5.4%. Radiographically, bone ingrowth occurred in all unrevised cups, and in 95% of unrevised stems. Osteolytic lesions appeared at an average of 3.8 years postoperatively. Femoral and pelvic osteolysis were seen in 21% and 4% of the surviving hips respectively. All femoral osteolytic lesions were found in the proximal Gruen zones 1 and 7. The mean annual polyethylene wear rate was 0.15 mm. Approximately one-third of the hips were observed to have excessive wear. Our experience with cementless Omnifit total hip prosthesis is encouraging. Of significant concern is the high incidence of excessive polyethylene wear and osteolysis.