bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis and Utility of Dihydropyridine Boronic Esters.
Authors: Panda Santanu , Coffin Aaron , Nguyen Q. Nhu , Tantillo Dean J. , Ready Joseph M. 
Published: May 2016

AbstractWhen activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester.
ChemInform Abstract: Synthesis of 2‐Aminoquinolines via Palladium‐Catalyzed Intermolecular Oxidative Cyclization of 2‐Vinylanilines with Isocyanides.
Authors: Zheng Qiang , Ding Qiuping , Wang Cong , Chen Wenfan , Peng Yiyuan 
Published: May 2016

Abstract2‐Aminoquinolines [(III), (V), and (VII)] are efficiently synthesized via palladium‐catalyzed intermolecular oxidative cyclization of 2‐vinylanilines with isocyanides.
ChemInform Abstract: P,S Ligands for the Asymmetric Construction of Quaternary Stereocenters in Palladium‐Catalyzed Decarboxylative [4 + 2] Cycloadditions.
Authors: Wei Yi , Lu Liang‐Qiu , Li Tian‐Ren , Feng Bin , Wang Qiang , Xiao Wen‐Jing , Alper Howard 
Published: May 2016

AbstractA hybrid P,S—ligand is designed by combining a chiral β‐amino sulfide and diphenyl phosphite.
ChemInform Abstract: Cross‐Dehydrogenative Coupling Reaction Using Copper Oxide Impregnated on Magnetite in Deep Eutectic Solvents.
Authors: Marset Xavier , Perez Juana M. , Ramon Diego J. 
Published: May 2016

AbstractVarious tetrahydroisoquinoline derivatives are prepared by a cross‐dehydrogenative coupling reaction using choline chloride/ethylene glycol (1:2) as a deep eutectic solvent (DES).
ChemInform Abstract: Synthesis of Substituted Benzo[ij]imidazo[2,1,5‐de]quinolizine by Rhodium(III)‐Catalyzed Multiple C—H Activation and Annulations.
Authors: Ge Qingmei , Li Bin , Wang Baiquan 
Published: May 2016

AbstractA novel method is elaborated for the preparation of benzo[ij]imidazo[2,1,5‐de]quinolizines (III) and (VII) by a Rh‐catalyzed cascade oxidative annulation of N‐arylimidazoles with two molecules of disubstituted alkynes.
ChemInform Abstract: One‐Pot Assembly of Fused Heterocycles via Oxidative Palladium‐Catalyzed Cyclization of Arylols and Iodoarenes.
Authors: Hong Fenglin , Chen Yingwen , Lu Beili , Cheng Jiajia 
Published: May 2016

AbstractThis efficient one‐pot reaction leads to a wide range of heterocycles via sequential oxidation, iodination, isomerization, and cyclization steps without purification of any reaction intermediates.
ChemInform Abstract: Stereoselective Synthesis of Polycycles Containing an Aziridine Group: Intramolecular Aza‐Diels—Alder Reactions of Unactivated 2H‐Azirines with Unactivated Dienes.
Authors: Xu Hua‐Dong , Zhou Hao , Pan Ying‐Peng , Ren Xin‐Tao , Wu Hao , Han Mei , Han Run‐Ze , Shen Mei‐Hua 
Published: May 2016

AbstractThe pyrolysis of vinyl azides containing a diene moiety gives rise to a variety of aziridine‐containing trans‐fused tricyclic core structures (28 examples).
ChemInform Abstract: Copper‐Catalyzed Consecutive Reaction to Construct Quinazolin‐4(3H)‐ones and Pyrido[2,3‐d]pyrimidin‐4(3H)‐ones.
Authors: Li Ting , Chen Minglu , Yang Lei , Xiong Zhengxin , Wang Yongwei , Li Fei , Chen Dongyin 
Published: May 2016

AbstractThe title reaction starts from easily available 2‐halobenzamides [e.g. (I)] or 2‐halonicotinamides (X) and proceeds probably via aromatic nuleophilic substitution of azide/copper catalyzed reduction/imine formation/cyclization/oxidation sequence.
ChemInform Abstract: Three‐Component [3 + 2 + 1] Cyclizations Leading to Densely Functionalized Benzo[4,5]thiazolo[1,2‐a]pyrimidines.
Authors: Bao Ming , Jiang Bo , Wang Haiying , Li Liang 
Published: May 2016

AbstractTitle compounds [(IV), (VI), and (VIII)] are conveniently synthesized by three‐component cyclization reaction in fairly good yields.
ChemInform Abstract: Regio‐ and Stereoselective Biocatalytic Monoamination of a Triketone Enables Asymmetric Synthesis of Both Enantiomers of the Pyrrolizidine Alkaloid Xenovenine Employing Transaminases.
Authors: Payer Stefan E. , Schrittwieser Joerg H. , Grischek Barbara , Simon Robert C. , Kroutil Wolfgang 
Published: May 2016

AbstractFor example, the (‐)‐enantiomer of xenovenine (IV) is prepared starting from triketone (I) through a short and high‐yielding total synthesis without the need for protecting strategies.
ChemInform Abstract: Designing a Dual‐Mode Broadband Solar Spectral Converter: The Example of Bi3+, Cr3+, Yb3+‐Tridoped Perovskite.
Authors: Lin Li‐Tian , Wu Xuan‐Ming , Wang Ting , Chen Dong‐Ju , Deng Chao , Meng Jian‐Xin , Cao Li‐Wei 
Published: May 2016

AbstractThe dual‐mode solar spectral converter CaTiO3: Bi3+, Cr3+, Yb3+ is prepared by firing stoichiometric amounts of CaCO3 and the metal oxides in air (1.
ChemInform Abstract: Chemoselective Access to Substituted Butenolides via a Radical Cyclization Pathway: Mechanistic Study, Limits and Application
Authors: Boussonniere Anne , Beneteau Romain , Rouaud Jean‐Christophe , Despiau Carole , Lebreton Jacques , Denes Fabrice 
Published: May 2016

AbstractReview: 64 refs.
Secure cyber incident analytics framework using Monte Carlo simulations for financial cybersecurity insurance in cloud computing
Authors: Gai Keke , Qiu Meikang , Hassan Houcine 
Published: May 2016

SummaryThe remarkable increasing demands of mitigating losses from cyber incidents for financial firms have been driving the rapid development of the Cybersecurity Insurance (CI). The implementations of CI have covered a variety of aspects in cyber incidents, from hacking to frauds. However, CI is still at its exploring stage so that there are a number of dimensions that are uncovered by the current applications. The cyber attack on critical infrastructure is one of the serious issues that prevents the expansions of CI. This paper addresses CI implementations focusing on cloud‐based service offerings and proposes a secure cyber incident analytics framework using big data, named as Cost‐Aware Hierarchical Cyber Incident Analytics (CA‐HCIA). The approach is designed for matching different cyber risk scenarios, which uses repository data. We use Monte Carlo simulations for extracting the incident features based on the training datasets. The main algorithms in CA‐HCIA include Monte Carlo Cyber Feature Extraction (MC2FE) and Optimal Cost Balance (OCA) Algorithms. Our experimental evaluation has provided the theoretical proof of the adoptability and feasibility. Results show that our proposal improves the cost of existing techniques in 7.98% and 15.39%. Copyright © 2016 John Wiley & Sons, Ltd.
Forest restoration: a global dataset for biodiversity and vegetation structure
Authors: Crouzeilles Renato , Ferreira Mariana S. , Curran Michael 
Published: May 2016

AbstractRestoration initiatives are becoming increasingly applied around the world. Billions of dollars have been spent on ecological restoration research and initiatives, but restoration outcomes differ widely among these initiatives in part due to variable socioeconomic and ecological contexts. Here, we present the most comprehensive dataset gathered to date on forest restoration. It encompasses 269 primary studies across 221 study landscapes in 53 countries and contains 4,645 quantitative comparisons between reference ecosystems (e.g., old‐growth forest) and degraded or restored ecosystems for five taxonomic groups (mammals, birds, invertebrates, herpetofauna, and plants) and five measures of vegetation structure reflecting different ecological processes (cover, density, height, biomass, and litter). We selected studies that (1) were conducted in forest ecosystems; (2) had multiple replicate sampling sites to measure indicators of biodiversity and/or vegetation structure in reference and restored and/or degraded ecosystems; and (3) used less‐disturbed forests as a reference to the ecosystem under study. We recorded (1) latitude and longitude; (2) study year; (3) country; (4) biogeographic realm; (5) past disturbance type; (6) current disturbance type; (7) forest conversion class; (8) restoration activity; (9) time that a system has been disturbed; (10) time elapsed since restoration started; (11) ecological metric used to assess biodiversity; and (12) quantitative value of the ecological metric of biodiversity and/or vegetation structure for reference and restored and/or degraded ecosystems. These were the most common data available in the selected studies. We also estimated forest cover and configuration in each study landscape using a recently developed 1 km consensus land cover dataset. We measured forest configuration as the (1) mean size of all forest patches; (2) size of the largest forest patch; and (3) edge:area ratio of forest patches. Global analyses of the factors influencing ecological restoration success at both the local and landscape scale are urgently needed to guide restoration initiatives and to further develop restoration knowledge in a topic area of much contemporary interest.
An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene‐Lifestyle Interactions Working Group
Authors: Sung Yun Ju , Winkler Thomas W. , Manning Alisa K. , Aschard Hugues , Gudnason Vilmundur , Harris Tamara B. , Smith Albert V. , Boerwinkle Eric , Brown Michael R. , Morrison Alanna C. , Fornage Myriam , Lin Li‐An , Richard Melissa , Bartz Traci M. , Psaty Bruce M. , Hayward Caroline , Polasek Ozren , Marten Jonathan , Rudan Igor , Feitosa Mary F. , Kraja Aldi T. , Province Michael A. , Deng Xuan , Fisher Virginia A. , Zhou Yanhua , Bielak Lawrence F. , Smith Jennifer , Huffman Jennifer E. , Padmanabhan Sandosh , Smith Blair H. , Ding Jingzhong , Liu Yongmei , Lohman Kurt , Bouchard Claude , Rankinen Tuomo , Rice Treva K. , Arnett Donna , Schwander Karen , Guo Xiuqing , Palmas Walter , Rotter Jerome I. , Alfred Tamuno , Bottinger Erwin P. , Loos Ruth J. F. , Amin Najaf , Franco Oscar H. , van Duijn Cornelia M. , Vojinovic Dina , Chasman Daniel I. , Ridker Paul M. , Rose Lynda M. , Kardia Sharon , Zhu Xiaofeng , Rice Kenneth , Borecki Ingrid B. , Rao Dabeeru C. , Gauderman W. James , Cupples L. Adrienne 
Published: May 2016

ABSTRACTStudying gene‐environment (G × E) interactions is important, as they extend our knowledge of the genetic architecture of complex traits and may help to identify novel variants not detected via analysis of main effects alone. The main statistical framework for studying G × E interactions uses a single regression model that includes both the genetic main and G × E interaction effects (the “joint” framework). The alternative “stratified” framework combines results from genetic main‐effect analyses carried out separately within the exposed and unexposed groups. Although there have been several investigations using theory and simulation, an empirical comparison of the two frameworks is lacking. Here, we compare the two frameworks using results from genome‐wide association studies of systolic blood pressure for 3.2 million low frequency and 6.5 million common variants across 20 cohorts of European ancestry, comprising 79,731 individuals. Our cohorts have sample sizes ranging from 456 to 22,983 and include both family‐based and population‐based samples. In cohort‐specific analyses, the two frameworks provided similar inference for population‐based cohorts. The agreement was reduced for family‐based cohorts. In meta‐analyses, agreement between the two frameworks was less than that observed in cohort‐specific analyses, despite the increased sample size. In meta‐analyses, agreement depended on (1) the minor allele frequency, (2) inclusion of family‐based cohorts in meta‐analysis, and (3) filtering scheme. The stratified framework appears to approximate the joint framework well only for common variants in population‐based cohorts. We conclude that the joint framework is the preferred approach and should be used to control false positives when dealing with low‐frequency variants and/or family‐based cohorts.
Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma
Authors: Geiger Jessica L. , Bauman Julie E. , Gibson Michael K. , Gooding William E. , Varadarajan Prakash , Kotsakis Athanasios , Martin Daniel , Gutkind Jorge Silvio , Hedberg Matthew L. , Grandis Jennifer R. , Argiris Athanassios 
Published: May 2016

AbstractBackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstrate aberrant activation of the phosphotidylinositol‐3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. We examined the efficacy of everolimus, an mTOR inhibitor, in patients with recurrent or metastatic HNSCC.MethodsThis single‐arm phase II study enrolled biomarker‐unselected patients with recurrent or metastatic HNSCC who failed at least 1 prior therapy. Everolimus was administered until progressive disease or unacceptable toxicity. Primary endpoint was clinical benefit rate (CBR). Secondary endpoints included progression‐free survival (PFS), overall survival (OS), and evaluation of tissue and serum biomarkers related to the PIK3CA pathway.ResultsSeven of 9 patients treated in the first stage were evaluable. No objective responses were seen; CBR was 28%. Three patients discontinued everolimus because of toxicity. Median PFS and OS were 1.5 and 4.5 months, respectively. No activating PI3K mutations were identified in available tumor tissue.ConclusionEverolimus was not active as monotherapy in unselected patients with recurrent/metastatic HNSCC. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1759–1764, 2016
Formulation of an Emitter Clogging Control Strategy for Drip Irrigation with Reclaimed Water
Authors: Bo Zhou , Yunkai Li , Peng Song , Tianzhi Wang , Yinguang Jiang , Honglu Liu 
Published: May 2016

AbstractControlling emitter clogging by reducing clogging substances is commonly used nowadays, but it is merely applied in clogged emitters, so establishing a convenient and pre‐treated emitter clogging control strategy is essential. In this paper, four types of non‐pressure‐compensating emitters were selected for a drip irrigation experiment using reclaimed water. Furthermore, suspended particles' components in reclaimed water treated with four technologies were tested, and then their components' relations with emitter clogging substances were studied. The results showed that clogging substances inside emitters and suspended particles both showed the complicated biofilm structure. The mineral components, relative phospholipid fatty acids (PLFAs) concentrations and dominant microbial communities of clogging substances inside emitters were consistent with those of suspended particles in the same reclaimed water. Mineral components were quartz, alkali‐feldspar and illite (total exceeding 88.0%). The relative PLFA concentrations were 0.7–0.8‰, while the main PLFAs were 12:0, i15:0, 16:0 and 18:0. Moreover, bacteroides, bacillus and cellvibrio were the dominant bacteria. However, solid particles in four types of reclaimed water represented more differences. The mineral components, relative PLFA concentrations and dominance indexes varied by 9.7–29.9, 57.9–253.0 and 2.6–49.0%, respectively. Therefore, an emitter‐clogging control strategy could be established according to suspended particles' components in the same reclaimed water. Copyright © 2016 John Wiley & Sons, Ltd.
Optimal response to habitat linkage of local fish diversity and mean trophic level
Authors: Xu Jun , Zhang Huan , Cai Yongjiu , García Molinos Jorge , Zhang Min 
Published: May 2016

AbstractSpatially segregated ecosystems are frequently subsidized by cross‐habitat linkages, but the extent to which the functional links between habitats influence local community attributes, such as consumer and food web structure is still poorly understood. Using the bidirectional linkage between benthic and pelagic habitats in floodplain lakes, we address this important question by looking for evidence of an optimal extent of habitat linkage supporting maximum taxonomic richness and mean trophic level. We then ask if there are significant changes in these local community attributes between historical and current communities, and if these reflect the history of species loss resulting from the intense human alteration of these lakes. We found a strong optimal response of maximum richness and mean trophic level along the pelagic‐benthic gradient, both across and within individual lakes. This is consistent with the expectation of optimal resource availability along the habitat linkage gradient supporting more and taxonomically richer communities. Comparison between historical and current assemblages revealed a significant decrease in the optimal linkage for maximum richness in response to the history of species loss, but not for maximum mean trophic level, probably a response to the increased habitat homogenization and enhanced productivity caused by the recent history of nutrient‐enrichment and habitat alteration. Our study provides strong evidence of high diversity and trophic level occurring at intermediate levels of coupling between pelagic and benthic resources, suggesting assemblage reliance on multiple production sources, and offers novel insight into the responses of this relationship to species loss due to human activities.
Reduction of the head effect in mobile devices
Authors: Lee Hongkoo , Jeon Jihwan , Qu Longyue , Shin Hyunwoong , Kim Hyeongdong 
Published: May 2016

ABSTRACTThis letter compares two types of antennas for Bluetooth applications in mobile handsets; in the presence and absence of a human head. A Planar Inverted F Antenna (PIFA) and a three dimensional loop‐type antenna were designed to fully cover Bluetooth services. The antennas are designed on a Frame Retardant Type 4 (FR‐4) substrate (ɛr = 4.4, tan δ = 0.02) with the size of 140 mm × 45 mm printed circuit board (PCB) with 1 mm thickness. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1806–1808, 2016
Fabrication tolerance and gain improvements of microstrip patch antenna at terahertz frequencies
Authors: Rabbani M. S. , Ghafouri‐Shiraz H. 
Published: May 2016

ABSTRACTIn this paper, a technique has been proposed to design microstrip antenna arrays at terahertz (THz) frequencies with improved gain and fabrication tolerance. The antenna is designed at 100GHz frequency and fabricated with simple laboratory based PCB etching process. The gain is improved to 13.4dBi with the help of only three patch elements. The measured −10dB return loss bandwidth (BW) is 5.55% of the central frequency. The measured and the simulation results are all in good agreement. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1819–1824, 2016
A compact MIMO antenna system for WLAN with enhanced isolation
Authors: Li Jiaqiang , You Xiaolong , Ge Junxiang , Li Peng , Chen Jinli 
Published: May 2016

ABSTRACTA compact multiple‐input and multiple‐output (MIMO) monopole antenna system for WLAN (2.45 GHz) with enhanced isolation is proposed. The proposed MIMO antenna system consists of two identical monopole antenna elements operating at the same frequency of 2.45 GHz. In order to improve the isolation performance, each antenna element is individually placed on one side of the substrate. With meandered strips, the size of the proposed antenna system is dramatically decreased to 15.9 mm × 9 mm. The isolation between the two antenna elements exceeds 18.29 dB by employing the orthogonal polarization diversity technique and the physical isolation method. The 10 dB bandwidth of the proposed antenna system reaches 120 MHz, which is wide enough for the practical application. Measured results are in close agreement with the simulated ones. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1968–1973, 2016
Miniaturized high‐selectivity microstrip bandpass filter using capacitively coupled stub‐loaded stepped‐impedance resonators
Authors: Kim Eun Seong , Adhikari Kishor Kumar , Kim Nam Young 
Published: May 2016

ABSTRACTThis paper presents a high‐selectivity compact microstrip bandpass filter (BPF) based on electromagnetically coupled, stub‐loaded, folded, asymmetric stepped‐impedance resonators (SIRs). The main advantage of the proposed BPF lies in its highly miniaturized effective size (0.2985 × 0.2298 λg2) and a wide upper‐stop‐band response. The high‐impedance sections of the SIRs were loaded with edge‐coupled, fork‐shaped stub loads in order to exploit the enhanced electromagnetic coupling of the SIRs, miniaturize the BPF effective size, and improve the skirt selectivity. In addition, the capacitive coupling of the SIRs with input and output as well as the use of fork‐shaped stubs and simple uniform‐impedance stubs generated three transmission zeros in the upper‐stop‐band, resulting in a wide stop‐band response. The measured pass‐band minimum return loss (26.6 dB) and maximum insertion loss (1.21 dB) for a protocol BPF with a central frequency of 5.17 GHz, three upper‐stop‐band transmission zeros with a minimum suppression level of 30.31 dB, and good agreement between the simulated and measured results verified the validity of the proposed high‐selectivity BPF. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2004–2010, 2016
Is Nephron Sparing Surgery Justified in Wilms Tumor With Beckwith–Wiedemann Syndrome or Isolated Hemihypertrophy?
Authors: Scalabre Aurélien , Bergeron Christophe , Brioude Frederic , Dainese Linda , Cropet Claire , Coulomb L'hermine Aurore , Pasqualini Claudia , Auber Frederic , Verschuur Arnauld , Schleiermacher Gudrun , Le Bouc Yves , Audry Georges , Irtan Sabine 
Published: May 2016

BackgroundPatients with Beckwith–Wiedemann syndrome (BWS) or isolated hemihypertrophy (HH) treated for a Wilms tumor (WT) carry an increased risk of developing metachronous lesion. There are no guidelines on precise indications for nephron sparing surgery (NSS) in unilateral WT (UWT). The objective of this retrospective study was to delineate the indications of NSS in patients with BWS/HH treated for WT and to evaluate their outcome.ProcedureAll cases of BWS/HH treated for a WT according to SIOP protocols from 1980 to 2013 were reviewed. Patients were divided into two groups (G): isolated UWT (G1) and bilateral lesions (G2) with two subgroups: bilateral tumors suspected of malignancy (G2a), and unilateral tumor suspected of malignancy with contralateral nephroblastomatosis (G2b).ResultsForty‐six patients were included (34 G1, three G2a, and nine G2b). Nine NSS and 25 total nephrectomies (TN) were performed in G1, two bilateral NSS and one NSS with contralateral TN in G2a, and eight NSS and one TN in G2b. The 3‐year event‐free survival was 92.3% (95% CI [77.9–97.5%]). One death occurred after a local relapse following a TN for a stage III stromal WT (G1) and another after a combined local and distant relapse following a NSS for a stage I diffuse anaplastic WT (G2b). There were two metachronous WT (4%), 3 years after a TN (G1) and 12 years after a NSS (G2b).ConclusionsNSS is recommended in bilateral WT and may be an option in selected UWT patients with BWS/HH because it was not associated with an increased risk of local relapse.
Genome sequence of Candida versatilis and comparative analysis with other yeast
Authors: Hou Lihua , Guo Lin , Wang Chunling , Wang Cong 
Published: May 2016

Abstract
The genome of Candida versatilis was sequenced to understand its characteristics in soy sauce fermentation. The genome size of C. versatilis was 9.7 Mb, the content of G + C was 39.74 %, scaffolds of N50 were 1,229,640 bp in length, containing 4711 gene. There were predicted 269 tRNA genes and 2201 proteins with clear function. Moreover, the genome information of C. versatilis was compared with another salt-tolerant yeast Zygosaccharomyces rouxii and the model organism Saccharomyces cerevisiae. C. versatilis and Z. rouxii genome size was close and both smaller than 12.1 for the Mb of S. cerevisiae. Using the OrthoMCL protein, three genomes were divided into 4663 groups. There were about 3326 homologous proteins in C. versatilis, Z. rouxii and S. cerevisiae.