bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of clustering methods in determining gold mineralization anomalies in the Janja area, Iran
Authors: Ebdali Mohammad , Hezarkhani Ardeshir 
Published: October 2024

The Janja region is located 30 kilometres NW of Sefidabeh city in Sistan and Baluchistan province, Iran. Considering the evidence of gold mineralization, it is necessary to identify the promising mineral areas in this region. Clustering is an important method in data mining science, and it is used to analyse and examine a significant amount of data with various characteristics. The purpose of this research is to investigate the ability of clustering methods to determine gold anomaly areas in the studied area and to compare the performances of each method. Hence, the K-Means and K-Medoids clustering algorithms have been used to investigate the behaviour of gold and copper elements towards each other. For this purpose, first, the number of clusters was changed from
k
= 3 to
k
= 11 and then the optimal number of clusters was obtained using the Davies–Bouldin, Silhouette and Calinski–Harabasz criteria. According to the results obtained, it can be said that both methods for estimating the gold grade are suitable and effective methods due to the high correlation coefficient. Also, the widely used K-Nearest Neighbour (KNN) method was used under the grade values of gold, silver, copper, lead and zinc in order to simulate and determine promising areas of gold mineralization. The results show that the KNN method has been effective for finding gold anomalies with proper performance.
Psychophysiological Factors Moderate Amygdala–Prefrontal Connectivity Linked to Perceived Peer Victimization and Depressive Symptoms in Preadolescent Migrant Children
Authors: Gong Xinyu , Tian Ting , Xu Jiahua , Qin Shaozheng , Lin Danhua 
Published: October 2024

Background: As a sense of an intense stressor, perceived peer victimization can cause adverse effects on mental health, like depressive symptoms. Yet, little is known about the neurobiological mechanisms underlying how perceived peer victimization causes and maintains depressive symptoms in preadolescence.Methods: Here we investigate the effects of peer victimization on amygdala subregional functional connectivity in 101 preadolescent migrant children, and their relations to depressive symptoms and potential protective factors of self‐esteem and daily cortisol. Further control analyses were conducted to verify whether there are any specific effects in migrant children compared to 54 age‐matched preadolescent children from nonmigrant background.Results: Children with higher perceived peer victimization exhibited greater intrinsic functional connectivity of the amygdala with the middle frontal gyrus extending into the superior frontal gyrus. Perceived peer victimization could account for an indirect association between amygdala hyperconnectivity and depressive symptoms. Moderated mediation analyses revealed that basolateral amygdala connectivity with the superior frontal gyrus acted as a neural marker linking peer victimization and greater risk for depressive symptoms only in preadolescent children with low self‐esteem or low daily cortisol.Conclusions: These findings suggest that considering neurobiological vulnerability and psychophysiological factors may gain a nuanced understanding of the adverse effects of perceived peer victimization on depressive symptoms, a risk for internalizing pathology. This study could inform personalized intervention strategies to prevent or ameliorate depressive symptoms in this disadvantaged population.
C-Reactive Protein Induces Immunosuppression by Activating FcγR2B in Pulmonary Macrophages to Promote Lung Metastasis
Authors: Feng Jun-Rui , Li Xue , Han Cong , Chang Yue , Fu Yu , Feng Gong-Chang , Lei Yutiantian , Li Hai-Yun , Tang Patrick Ming-Kuen , Ji Shang-Rong , Hou Yuzhu , Wu Yi 
Published: October 2024

Abstract
C-reactive protein (CRP) is a liver-derived acute phase reactant that is a clinical marker of inflammation associated with poor cancer prognosis. Elevated CRP levels are observed in many types of cancer and are associated with significantly increased risk of metastasis, suggesting that CRP could have prometastatic actions. In this study, we reported that CRP promotes lung metastasis by dampening the anticancer capacity of pulmonary macrophages in breast cancer and melanoma. Deletion of CRP in mice inhibited lung metastasis of breast cancer and melanoma cells without significantly impacting tumor growth compared with wild-type mice. In addition, the lungs of CRP-deficient mice were enriched for activated pulmonary macrophages, which could be reduced to the level of wild-type mice by systemic administration of human CRP. Mechanistically, CRP blocked the activation of pulmonary macrophages induced by commensal bacteria in a FcγR2B-dependent manner, thereby impairing macrophage-mediated immune surveillance to promote the formation of a premetastatic niche in the lungs of tumor-bearing mice. Accordingly, treatment with specific CRP inhibitors activated pulmonary macrophages and attenuated lung metastasis in vivo. These findings highlight the importance of CRP in lung metastasis, which may represent an effective therapeutic target for patients with advanced solid cancers in clinics.
Significance: CRP maintains host–commensal tolerance by inhibiting pulmonary macrophage activation and can be targeted to remodel the premetastatic niche in the lung to lower the risk of cancer metastasis.
See related commentary by Saal et al., p. 4121
Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer
Authors: Van Cutsem Eric , Collignon Joelle , Eefsen Rikke L. , Ochsenreither Sebastian , Zvirbule Zanete , Ivanauskas Audrius , Arnold Dirk , Baltruskeviciene Edita , Pfeiffer Per , Yachnin Jeffrey , Magnusson Susanne , Rydberg Millrud Camilla , Sanfridson Annika , Losic Nedjad , Garcia-Ribas Ignacio , Tersago Dominique , Awada Ahmad 
Published: October 2024

Abstract

Purpose:
IL1 pathway upregulation is implicated in pancreatic ductal adenocarcinoma (PDAC) progression, therapy resistance, and survival. Nadunolimab is an IL1 receptor accessory protein (IL1RAP)–targeting antibody with enhanced antibody-dependent cellular cytotoxicity that blocks IL1α/IL1β signaling. We investigated efficacy and safety of nadunolimab in PDAC, in combination with gemcitabine/nab-paclitaxel (GN).

Patients and Methods:
Patients with previously untreated locally advanced/metastatic PDAC received nadunolimab (1.0–7.5 mg/kg) every 2 weeks with standard GN. The primary objective was safety; secondary objectives were antitumor response, progression-free survival, and overall survival (OS). Correlations between serum and tumor biomarkers and clinical response were explored.

Results:
Seventy-six patients were enrolled; the median age was 63 years (range, 43–89), 42% were female, 97% had metastatic disease, and 9% had received adjuvant chemotherapy. The most frequent grade ≥3 adverse event was neutropenia (66%), typically during cycle 1. Infusion-related reactions occurred in 29% (grade 3, 3%). Only 1 of the 76 patients had grade 3 or above peripheral neuropathy. No marked dose-dependent differences in safety or efficacy were observed among the four dose groups. The median OS was 13.2 months (95% confidence interval, 11.0–15.6), and the 1-year survival rate was 58%. The median immune PFS (immune Response Evaluation Criteria in Solid Tumours) was 7.1 months (95% confidence interval, 5.2–7.4). Treatment efficacy was higher in patients with high versus low tumor baseline IL1RAP expression (OS 14.2 vs. 10.6 months; P = 0.012). A reduction in serum IL8 on treatment correlated with prolonged OS.

Conclusions:
Nadunolimab combined with GN shows promising efficacy and manageable safety in locally advanced/metastatic PDAC. Higher tumor baseline IL1RAP expression correlated with better outcome.
Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma
Authors: Alpen Karen , Maclnnis Robert J. , Vajdic Claire M. , Lai John , Dowty James G. , Koh Eng-Siew , Hovey Elizabeth , Harrup Rosemary , Nguyen Tuong L. , Li Shuai , Joseph David , Benke Geza , Dugué Pierre-Antoine , Southey Melissa C. , Giles Graham G. , Nowak Anna K. , Drummond Katharine J. , Schmidt Daniel F. , Hopper John L. , Kapuscinski Miroslaw K. , Makalic Enes 
Published: October 2024

Abstract
Glioma is a rare and debilitating brain cancer with one of the lowest cancer survival rates. Genome-wide association studies have identified 34 genetic susceptibility regions. We sought to discover novel susceptibility regions using approaches that test groups of contiguous genetic markers simultaneously. We analyzed data from three independent glioma studies of European ancestry, GliomaScan (1,316 cases/1,293 controls), Australian Genomics and Clinical Outcomes of Glioma Consortium (560 cases/2,237 controls), and Glioma International Case-Control Study (4,000 cases/2,411 controls), using the machine learning algorithm DEPendency of association on the number of Top Hits and a region-based regression method based on the generalized Berk–Jones (GBJ) statistic, to assess the association of glioma with genomic regions by glioma type and sex. Summary statistics from the UCSF/Mayo Clinic study were used for independent validation. We conducted a meta-analysis using GliomaScan, Australian Genomics and Clinical Outcomes of Glioma Consortium, Glioma International Case-Control Study, and UCSF/Mayo. We identified 11 novel candidate genomic regions for glioma risk common to multiple studies. Two of the 11 regions, 16p13.3 containing RBFOX1 and 1p36.21 containing PRDM2, were significantly associated with female and male glioma risk respectively, based on the results of the meta-analysis. Both regions have been previously linked to glioma tumor progression. Three of the 11 regions contain neurotransmitter receptor genes (7q31.33 GRM8, 5q35.2 DRD1, and 15q13.3 CHRNA7). Our region-based approach identified 11 genomic regions that suggest an association with glioma risk of which two regions, 16p13.3 and 1p36.21, warrant further investigation as genetic susceptibility regions for female and male risk, respectively. Our analyses suggest that genetic susceptibility to glioma may differ by sex and highlight the possibility that synapse-related genes play a role in glioma susceptibility.

Significance:
Further investigation of the potential susceptibility regions identified in our study may lead to a better understanding of glioma genetic risk and the underlying biological etiology of glioma. Our study suggests sex may play a role in genetic susceptibility and highlights the importance of sex-specific analysis in future glioma research.
Socrates’ Ethical Argument for His Eschatology in the Gorgias
Authors: O’Keefe Tim 
Published: October 2024

Abstract
Socrates has an implicit argument for his afterlife story that concludes the Gorgias, with two key premises. One is at 527a–c, where he summarizes the ethical position he has been arguing for through most of the dialogue, regarding the intrinsic goodness of justice, the intrinsic badness of injustice, and the desirability of rehabilitative punishments. The second occurs at 507e–508a, where Socrates asserts that the universe is held together by justice. This argument explains why Socrates regards his story as a logos, not merely a muthos. It also helps us understand the nature of the rewards and punishments in his story.
Mitochondrial data unravels the human-mediated introduction of Mediodactylus kotschyi (Squamata: Gekkonidae) to the Central Balkan Peninsula
Authors: Delcour Nathan , Urošević Aleksandar , Anđelković Marko , Maričić Marko , Šević Mirko , Vučić Tijana , Tomović Ljiljana , Rato Catarina 
Published: October 2024

Abstract
Kotschy’s gecko, Mediodactylus kotschyi, is native to the Eastern part of the Mediterranean Basin and a successful colonizer, with an extensive distribution across the Balkans and outside its native range. In Serbia, it was presumed native in Prizren (Kosovo and Metohija province) and introduced across the remaining territory. To explore the origin of Serbian Kotschy’s gecko, we collected specimens from most of the Serbian populations where the species was recorded and assessed their phylogenetic relationships based on three mtDNA markers (COI, cytb, 16S rRNA) under Maximum Likelihood (ML) and Bayesian Inference (BI) approaches. First, our results support that the specimens found in Serbia belong to M. kotschyi. Second, all populations except Prizren belong to the subspecies M. kotschyi skopjensis. Furthermore, the Italian populations are sister to the specimens from Prizren, suggesting a Balkan origin for these populations, which settled in Apulia likely through ancient human-mediated dispersion. The small genetic differentiation found suggests that Kotschy’s gecko rapidly colonized the Central Balkans, originating from Northern Greece and North Macedonia. The results also suggest a story of multiple, complex (most likely) human-mediated introductions. However, further studies should be conducted to properly elucidate the colonization pathways, and to truly disentangle the potential fast natural range expansion from an anthropogenic dispersion of this gecko species.
Digital Pentecostal Sacramentality
Authors: Cartledge Mark J. 
Published: October 2024

Abstract
This article explores the online healing praxis of Benny Hinn through the lens of Pentecostal sacramentality. It outlines the way Hinn uses Zoom software in his tv studio to extend his healing ministry to people who have joined the meeting in real time from around the globe. The contribution of Nathaniel J. Homewood is used to analyse Hinn’s healing praxis online (designated as ‘Zoompartation’), which illustrates the haptic culture of Pentecostalism. It is then reframed using Wolfgang Vondey’s discussion of the Pentecostal ‘altar’ and the concept of sacramentality. The argument of this study is that Hinn has adapted his already implicit sacramentality to perform what might be termed a Pentecostal digital haptic sacramentality. This study builds on the theology of mediation in Pentecostal and Charismatic theology and develops it by giving more attention to symbolic action, hence the notion of sacramentality. The article is significant in developing the theological understanding of digital Pentecostalism and contributes to digital ecclesiology.
Effects of TDCS combined with Mat exercises on balance in patients with stroke
Authors: Goel P. , Malik M. , Gera C. , Kaur J. 
Published: October 2024

Abstract
The purpose of the present study was to evaluate the effect of transcranial direct current stimulation (TDCS) along with Mat exercises in stroke. A single blinded RCT with ‘intention to treat’ analysis was conducted according to the ‘Consolidated standards of reporting trial (CONSORT)’ 2010 guidelines. Patients suffering from haemorrhagic/ischemic stroke with unilateral hemiplegia having balance problems and age group above the 40 years were included in this study. A total of 32 participants were randomly allocated into two groups: Group A (n = 16) and Group B (n = 16). The patients in Group A were treated with TDCS and Mat exercises whereas participants of Group B were given sham TDCS for 15 min and conventional balance training. The treatment was given alternatively, thrice a week, for 2 weeks. Entire procedure was completed within 45-60 min. Two outcome measures were used to assess the balance, i.e. functional reach test (FRT) and time up & go test (TUG). There were more males than females in both experimental groups. Results of baseline comparison reported that there was a statistically non-significant difference in the variables and the data were normally distributed. Results of the within group analysis found that there was statistically significant improvement in pre- and post-intervention scores of both groups. Results of between group analysis showed that there was a statistically significant improvement in the variables of Group A compared to Group B. This study concludes that the combined use of TDCS along with Mat exercises can improve the balance as compared to Sham TDCS along with conventional balance training.
Effects of complex probiotics on intestinal function and its regulatory mechanism in patients with constipation
Authors: Zhang X. , Jia Y. , Li X. , Wang X. , Li L. , Zhang P. , Dong X. , Ze X. , An Y. , Li J. 
Published: October 2024

Abstract
Chronic constipation is a multi-symptomatic, multifactorial, and heterogeneous gastrointestinal disorder. Current pharmacological treatments for chronic constipation are limited and might negatively impact the patients’ quality of life. Although probiotics have been shown to improve constipation symptoms, their specific regulatory mechanisms remain unclear. This study sought to explore how probiotic complexes may affect chronic constipation by improving patients’ defecation habits. Furthermore, microbial profiles and non-targeted metabolites were assessed to explore the metabolic pathways involved in the improvement of constipation by probiotics. Patients with chronic constipation were treated using a single-blind, randomised, placebo-controlled trial design. The experimental group was administered Lactobacillus powder prepared from 15 probiotic products, and maltodextrin was used as a placebo. Samples were collected twice daily for 4 weeks, and faecal samples were analysed using 16S rRNA sequencing and untargeted metabolic histology. Probiotic treatment changed the makeup of the gut microbiota, enhanced the quantity of Bifidobacterium and Lactobacillus, and markedly reduced clinical symptoms. The 16S rRNA analysis revealed that the abundance of Bifidobacterium and Prevotella increased while that of Thickettsia declined. Moreover, there was a decrease in the abundance of Faecalibacterium and Roseburia. Non-targeted metabolomics analysis identified several differential metabolites, including succinic acid, fumaric acid, cholesterol, xanthurenic acid, 3-alpha,7-alpha-trihydroxy-5beta-cholestan-26-oic, and N-methyltryptamine. KEGG analysis showed that these metabolites were mainly associated with metabolic pathways such as primary bile acid biosynthesis, tryptophan metabolism, alanine, aspartate and glutamate metabolism, phenylalanine metabolism, cholesterol metabolism, and propanoate metabolism. In this study, gut microbiome and non-targeted metabolome analyses were performed on collected faecal samples to compare characteristic microorganisms and differential metabolites to provide new insights and references for probiotic intervention in constipation.
Trial registered at chictr.org.cn under number: ChiCTR2200056274
AI As Artificial Memory: A Global Reconfiguration of Our Collective Memory Practices?
Authors: Schuh Julien 
Published: October 2024

Abstract
ai’s evolution has drastically reshaped our relationship with collective memory. Large ai models, like gpt and dall·E, have emerged as memory agents, assimilating vast cultural and historical data across centuries. Unlike traditional digital repositories, these tools employ an analogical approach, capturing the complexity of human memory. Their potential to weave together fragmented pieces of the past offers new ways to delve into historical and cultural data. Tech giants are ambitiously positioning these ai models as primary mediators for information access, integrating them into popular platforms. While they present new forms of collective memory, their widespread use raises profound ethical concerns. Challenges arise regarding historical truth, representativeness, and data reuse, leading to debates on data ownership and the governance of digital collective memory.
The THINICE Field Campaign: Interactions between Arctic Cyclones, Tropopause Polar Vortices, Clouds, and Sea Ice in Summer
Authors: Rivière Gwendal , Delanoë Julien , Doyle James D. , Methven John , Barrell Chris , Fearon Matthew , Gray Suzanne , Johnson Aaron , Jourdan Olivier , Lachlan-Cope Tom , Renfrew Ian , Torn Ryan D. , Volonté Ambrogio , Weiss Alexandra , Wimmer Meryl , Aubry Clémantyne , Baudoux Antoine , Bazile Eric , Beeden Daniel , Bennett Miriam , Biernat Kevin , Bitz Cecilia M. , Blanchard-Wrigglesworth Edward , Bounissou Sophie , Bray Matthew , Burg Tomer , Burzdak Joseph , Businger Steven , Capute Peyton , Caudoux Christophe , Cavallo Steven , Cossalter Laure , Cozzolino Capucine , Croad Hannah , Douet Vincent , Elvidge Andrew , Finocchio Peter , Gourbeyre Christophe , Harvey Ben , Huet Kevin , Hutchinson Todd , Ladkin Russ , Marshland Kai , Martinez-Alvarado Oscar , Mioche Guillaume , Pantillon Florian , Paquette Cameron , Parsons David B. , Persson Ola , Raillard Lea , Raut Jean-Christophe , Seity Yann , Trules Jérémie , Vignon Etienne , Wang Xuguang 
Published: October 2024

Abstract
The THINICE field campaign, based in Svalbard in August 2022, provided unique observations of summertime Arctic cyclones, their coupling with cloud cover, and their interactions with tropopause polar vortices and sea ice conditions. THINICE was motivated by the need to advance our understanding of these processes and to improve coupled models used to forecast weather and sea ice, as well as long-term projections of climate change in the Arctic. Two research aircraft were deployed with complementary instrumentation. The Service des Avions Français Instrumentés pour la Recherche en Environnement (Safire) Aerei da Trasporto Regionale 42 (ATR42) aircraft, equipped with the radar–lidar (RALI) remote sensing instrumentation and in situ cloud microphysics probes, flew in the midtroposphere to observe the wind and multiphase cloud structure of Arctic cyclones. The British Antarctic Survey Meteorological Airborne Science Instrumentation (MASIN) aircraft flew at low levels measuring sea ice properties, including surface brightness temperature, albedo and roughness, and the turbulent fluxes that mediate exchange of heat and momentum between the atmosphere and the surface. Long-duration instrumented balloons, operated by WindBorne Systems, sampled meteorological conditions within both cyclones and tropospheric polar vortices across the Arctic. Several novel findings are highlighted. Intense, shallow low-level jets along warm fronts were observed within three Arctic cyclones using the Doppler radar and turbulence probes. A detailed depiction of the interweaving layers of ice crystals and supercooled liquid water in mixed-phase clouds is revealed through the synergistic combination of the Doppler radar, the lidar, and in situ microphysical probes. Measurements of near-surface turbulent fluxes combined with remote sensing measurements of sea ice properties are being used to characterize atmosphere–sea ice interactions in the marginal ice zone.