bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fenestrations of the Basilar Artery Demonstrated on Magnetic Resonance Angiograms: An Analysis of 212 Cases
Authors: Sogawa Keiji , Kikuchi Yoichi , O'Uchi Toshihiro , Tanaka Michihiro , Inoue Tomio 
Published: January 2017

Fenestration of the basilar artery (BA) is a rare variant of the intracranial artery, well demonstrated in autopsy and angiographic studies. Some angiographic series show a high incidence of associated aneurysms at the basilar fenestration site. The purpose of this study is to report the incidence of BA fenestration, its configurations, associated aneurysms, and arterial anomalies in a large series of intracranial MR angiograms (MRAs). A total of 16,416 MRAs were retrospectively reviewed to identify the location, size and associated intracranial arterial anomalies of BA fenestrations. All images were obtained with the time-of-flight (TOF) technique. Of the 16,416 MRAs, 215 fenestrations were found in 212 cases (1.29%). Most fenestrations were located in the proximal BA. The average length of the fenestration was 4.6 mm; the largest was 15.6 mm. No aneurysm was found at the site of the fenestration. Thirteen aneurysms were found in nine cases at locations other than the BA: seven in the middle cerebral artery (MCA), one in the anterior cerebral artery (ACA), one in the anterior communicating artery (Acom), one in the vertebral artery (VA), one at the carotid siphon, and two at the internal carotid-posterior communicating artery (IC-PC). Arterial anomalies in other locations were found in 26 cases. BA fenestrations were found in 1.29% of the 16,416 cases studied. There were no aneurysms at the BA fenestration site. Aneurysms at the BA fenestration site may be an exceedingly rare phenomenon.
Anatomoclinical Aspects of Dural Arteriovenous Shunts in Children
Authors: Lasjaunias P. , Magufis G. , Goulao A. , Piske R. , Suthipongchai S. , Rodesch R. , Alvarez H. 
Published: January 2017

We review 29 children (presenting between 1985–1996) with dural arteriovenous shunts. By analysing the anatomical features from axial and angiographic imaging and examining the clinical history and pathophysiological characteristics, we hypothesize that different diseases can be distinguished and divided into three groups: dural sinus malformation (DSM), infantile type of dural arteriovenous shunts (IDAVS) and adult type of dural arteriovenous shunts (ADAVS). It was helpful to classify these diseases when assessing the treatment options and long-term prognosis. Our group of 29 children comprised 19 DSM, 7 IDAVS, 3 ADAVS. A slight male preponderance was noted in the DSM group. The range of symptoms encountered included mild cardiac failure and coagulopathies, macro-crania, developmental delay, mental retardation, seizures and focal neurological deficits (in the neonates and early infancy age group) with or without haemorrhagic venous infarctions secondary to venous outlet restriction. We found all types of lesion in the neonatal age group, but in general the different types of lesion correspond to the paediatric subgroups with DSM occurring in the neonatal age group, IDAVS in infancy and ADAVS in children. DSMs are revealed in the first few months of live and the prognosis is good if the torcular is not involved. Two types can be seen: 1) DSM involving the posterior sinus with or without the confluens sinusum, with giant dural lakes and slow flow mural AV shunting. Spontaneous thrombosis may further restrict cerebral venous drainage and subsequently lead to intraparenchymatous haemorrhagic infarction. 2) DSM involving the jugular bulb with otherwise normal sinuses but associated with a high flow sigmoïd sinus AVF. The prognosis is excellent with embolisation treament. IDAVS are high flow and low pressure. The sinuses are large and patent with no lakes. Clinical onset is seen in the first few years of life and the shunts are initially well tolerated. Progressive symptoms (symptoms of raised ICP and venous ischaemia) develop at a later age and initially respond to partial embolisation. The long term prognosis is poor with neurological deterioration in early adulthood. ADAVS present in all age groups and almost all of them are located in the cavernous venous plexus. Post embolisation outcome is excellent.
The Marginal Sinus Normal Anatomy and Involvement with Arteriovenous Fistulae
Authors: Evans A.J. , Kallmes D.F. , Jensen M.E. , Dion J.E. 
Published: January 2017

Rationale and Objectives The marginal sinus is an infrequently recognized dural venous sinus at the rim of the foramen magnum. Recognition of this sinus and knowledge of its anatomy will enable the neurointerventionalist to treat dural arteriovenous fistulae (AVF) involving the marginal sinus. Methods We present a report of the signs, symptoms, angiographic appearance, and treatment results of two patients with marginal sinus dural AVF. In addition, we review the literature concerning the marginal sinus and describe the anatomy of this region. Angiograms depicting normal variants are presented to illustrate the various patterns that may be encountered when the marginal sinus participates in the venous drainage of the cranium. Results In two patients with dural arteriovenous fistulae (AVF) the marginal sinus was found to be the venous receptacle. The marginal sinuses are dural venous sinuses located at the lateral margins of the foramen magnum. Superiorly, the marginal sinus connects to the occipital sinus, a single or paired midline venous channel arising at the torcular Herophili or the medial transverse sinus. The marginal sinus typically drains into the sigmoid sinus, and may connect to the condylar veins, the superior aspect of the internal venous plexus, or the occipital plexus. Occasionally, the occipital-marginal sinus system represents the primary drainage pathway of the cranium, completely replacing the transverse sinus. In the two patients we treated with dural AVF in this location, simple transvenous packing of the sinus effectively cured the lesion. Conclusions The marginal sinus is a dural venous sinus that can rarely be involved with a dural AVF. Recognition that a dural AVF involves the marginal sinus can facilitate safe, effective therapy.
A Case of Vertebrovertebral Arteriovenous Fistula Presenting with Subarachnoid Haemorrhage
Authors: Kominami S. , Liu Y. , Alvarez H. , Rodesch G. , Coubes P. , Lasjaunias P. 
Published: January 2017

A rare paediatric case of vertebrovertebral arteriovenous fistula presented with a subarachnoid haemorrhage. A 12 year-old boy, who fell on his back at school, presented with a one week history of headache, vomiting, and double vision. Computed tomography (CT) scan revealed subarachnoid haemorrhage. Magnetic resonance imaging (MRI) demonstrated a tortuous vessel on the anterior surface of the spinal cord. Selective angiography showed an arteriovenous fistula of the left vertebral artery at the level of C1. The venous drainage of the fistula refluxed into the medullary vein at the level of C6-7, and drained upwards into the posterior fossa veins. An endovascular detachable balloon technique was employed and complete occlusion of the fistula was achieved.
Volume Determination of Intracranial Arteriovenous Malformations Prior to Stereotactic Radiosurgical Treatment
Authors: Ericson K. , Söderman M. , Karlsson B. , Lindquist C. 
Published: January 2017

Exact dose planning for stereotactic radiosurgery was enabled in connection with diagnostic angiography or at the end of an endovascular procedure by simply placing a stereotactic localizing box onto the head of the patient while acquiring PA and lateral angiographic views. The fiducials engraved on the localizing box enabled the appropriate images to be scaled to the stereotactic space. Regular dose planning was then performed after estimating the size of the patient's head. A prediction of the chances of obliteration and the risks of complication could then be made immediately after the endovascular or diagnostic procedure, and further therapy could be selected much more confidently. This technique may also be used at centres without facilities for radiosurgical treatment if only the localizing box is available. The images may then be sent for evaluation to a unit with dose planning equipment. The technique is simple and involves little risk, significantly improving patient management. Digital subtraction angiography was used in this study. A correction algorithm was used to minimize the geometric distortion inherent to the digital technique.
Post-Procedure CT Follow-up after Percutaneous Automated Lumbar Nucleotomy
Authors: Dullerud R. , Johansen J.G. 
Published: January 2017

In order to evaluate the incidence of soft tissue changes after automated lumbar nucleotomy, a prospective cohort study was performed with follow-up CT within four to six hours after treatment of 97 discs in 88 patients. The CT scans were normal at 47 levels and abnormal at 50. At 11 levels traces of blood were seen along the trajectory, of which nine were located in the subcutaneous fat, one in the extensor and one in the psoas muscle. Small gas collections were observed at 42 levels. Twenty-one of them were located in the extensor and two in the psoas muscle, seven in the subcutaneous fat, two in the epidural space and ten in multiple locations. The abnormal scans were not associated with clinical symptoms different from those with normal scans. The results support previous reports indicating that this procedure is associated with low morbidity and complication rates.
A Revised Concept of the Congenital Nature of Cerebral Arteriovenous Malformations
Authors: Lasjaunias P. 
Published: January 2017

Cerebral arteriovenous lesions are in general considered to be congenital in nature despite the fact that there is no evidence that the AV shunts diagnosed in adults are present at birth in a similar format. Construction of a vascular structure is the result of complex biological influences starting in the embryo, and continuing in the foetus, the neonate and the young infant. This vascular tree has to be maintained, repaired and modified according to metabolic demands, requiring over time the renewal of the entire structure. This is also genetically programmed and controlled. Both construction and maintenance involve repetitive steps and feedback towards the vascular tree according to the demands. Alterations in the programme or in the cellular logistics to achieve it, will create a different construction of the blood vessel wall. Analysis of the origin of the cerebrofacial endothelial cell would suggest that, the earlier a causative event occurs the larger the area of impact, and the higher the chances of apparent multifocality will be. The later the trigger occurs the more focal the defect and the smaller the lesion. If so, growth of an AVM as such should not occur; large nidi will not result from the growth of smaller ones. The impact of Rendu-Osler-Weber (ROW) disease on the venous endothelial cells and the polymorphism observed in cerebral arteriovenous shunts in ROW patients may outline the role played by the veins as the primary target in the development of cerebral AVMs. The venous and arterial angiopathy related to chronic high flow (or flow changes beyond normal equilibrium) impact a normally reacting vasculature which has been “abnormally” triggered by an AVM. This intraluminal trigger represents a “stress trigger” which can be flow, pressure or “other” related factors. This interpretation identifies the so-called AVMs to be the expression of various diseases rather than the disease itself. They are the result and negative impact of biological dysfunction of the remodelling process at the capillarovenous junction.
Making Evidence Available: Prognostic Classification Systems
Authors: Mansmann U. 
Published: January 2017

Claims of treatment selectivity can represent an important therapeutic advance: however, most such claims cannot be confirmed with independent data. This implies a management dilemma when confronted with ambiguous information on the risks of therapies and, most of all, insufficient criteria for identifying patients at risk. An accurate assessment of prognosis can help overcome the uncertainties facing the patients. But the identification of prognostic factors is subject to certain caveats. An essential part of prognostic factor analysis is standardization, a fact that is often overlooked. Thus, two different studies identifying the prognostic value of a factor may not be truly comparable, making a meaningful comparison difficult. Therefore, the development of an accurate prognostic system provides a method of conveying clinical experience to others without ambiguity.
Hair transplantation in burn scar alopecia
Authors: Farjo Bessam , Farjo Nilofer , Williams Greg 
Published: January 2017

[Formula: see text] Treating patients with burn alopecia or hair loss can often be a challenge to both the surgeon and the patient. As with other reconstructive procedures that are required in the post-burn phase, this is usually a multiple stage process often requiring surgery over several years. This is because graft take is not as reliable as in healthy non-scarred skin and may need repeating to achieve adequate density. Also, different areas of hair loss may need to be addressed in separate procedures. There are several limiting factors that will determine whether or not a patient is a candidate for hair restoration which includes but is not limited to the amount of hair loss and the availability of suitable donor hair. Here we discuss how the current surgical technique of hair transplant surgery by follicular unit extraction (FUE) or strip follicular unit transplant (FUT) has become the treatment of choice for alopecic areas that require a more refined aesthetic result. Eyebrow, eyelash, beard and scalp hair loss can all have a negative impact on a burn survivor’s self-esteem and even if surgery is not a possibility, there are non-surgical options available for hair restoration and these are also discussed.
Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era
Authors: Mantha Simon , Goldman Debra A. , Devlin Sean M. , Lee Ju-Whei , Zannino Diana , Collins Marnie , Douer Dan , Iland Harry J. , Litzow Mark R. , Stein Eytan M. , Appelbaum Frederick R. , Larson Richard A. , Stone Richard , Powell Bayard L. , Geyer Susan , Laumann Kristina , Rowe Jacob M. , Erba Harry , Coutre Steven , Othus Megan , Park Jae H. , Wiernik Peter H. , Tallman Martin S. 
Published: January 2017

Key Points
High WBC is an independent predictor of early HD in APL.
What specific plant traits support ecosystem services such as pollination, bio-control and water quality protection in temperate climates? A systematic map protocol
Authors: Blowers Claire J. , Cunningham Heidi M. , Wilcox Andrew , Randall Nicola P. 
Published: January 2017

Abstract
Background
Agricultural intensification has increased diffuse source pollution within water catchments, reduced heterogeneity within the landscape and caused major declines in farmland wildlife, including birds, mammals, invertebrates and wildflowers. This increase in pollution and wildlife decline, has effected three vital ecosystem services, pollination, biological pest control and water quality protection. The morphological traits of plant species, such as floral display size and leaf area, provide support to these services and vegetative strips can be established with plants that have these desirable traits. Vegetative strips are widely used across Europe and integrated into government environmental schemes such as The Common Agricultural Policy and The Water Framework Directive. However, issues of land availability and food security require a sustainable intensification of current agricultural practices. One component of this process is to sow vegetative strips that are designed to support multiple ecosystem services. To do this, combinations of plant species that will support specific ecosystem services, have been designed. However, to enable a fully-informed design process, evidence must be collated on which specific plant traits provide the support to the target ecosystem services. We propose to systematically map all evidence on which specific plant traits provide support for three of the most vital ecosystem services, pollination, bio-control and water quality protection. Information from this map could inform future decisions on which plant species are suitable for inclusion within a multifunctional vegetative strip that aims to provide the target ecosystem services. The aim of this systematic map is to create a searchable database of studies that demonstrate evidence of plant traits and how they support the named ecosystem services.

Methods
Seven bibliographic databases, 25 organisational websites and 2 search engines, will be systematically searched with predefined and tested key search terms. All searches will be undertaken in English and only those undertaken in a temperate climate zone will be considered. Studies found will be screened at title, abstract and full text levels, recording the number of excluded articles. Following full text assessment, the meta-data of included studies will be incorporated into a systematic map database in Microsoft Access. A report will summarise the evidence, highlight any knowledge gaps, and provide recommendations for future research.
Real-time rendering of aerial perspective effect based on turbidity estimation
Authors: Morales Carlos , Oishi Takeshi , Ikeuchi Katsushi 
Published: January 2017

Abstract
In real outdoor scenes, objects distant from the observer suffer from a natural effect called aerial perspective that fades the colors of the objects and blends them to the environmental light color. The aerial perspective can be modeled using a physics-based approach; however, handling with the changing and unpredictable environmental illumination as well as the weather conditions of real scenes is challenging in terms of visual coherence and computational cost. In those cases, even state-of-the-art models fail to generate realistic synthesized aerial perspective effects. To overcome this limitation, we propose a real-time, turbidity-based, full-spectrum aerial perspective rendering approach. First, we estimate the atmospheric turbidity by matching luminance distributions of a captured sky image to sky models. The obtained turbidity is then employed for aerial perspective rendering using an improved scattering model. We performed a set of experiments to evaluate the scattering model and the aerial perspective model. We also provide a framework for real-time aerial perspective rendering. The results confirm that the proposed approach synthesizes realistic aerial perspective effects with low computational cost, outperforming state-of-the-art aerial perspective rendering methods for real scenes.
Actin visualization at a glance
Authors: Melak Michael , Plessner Matthias , Grosse Robert 
Published: January 2017

ABSTRACT
Actin functions in a multitude of cellular processes owing to its ability to polymerize into filaments, which can be further organized into higher-order structures by an array of actin-binding and regulatory proteins. Therefore, research on actin and actin-related functions relies on the visualization of actin structures without interfering with the cycles of actin polymerization and depolymerization that underlie cellular actin dynamics. In this Cell Science at a Glance and the accompanying poster, we briefly evaluate the different techniques and approaches currently applied to analyze and visualize cellular actin structures, including in the nuclear compartment. Referring to the gold standard F-actin marker phalloidin to stain actin in fixed samples and tissues, we highlight methods for visualization of actin in living cells, which mostly apply the principle of genetically fusing fluorescent proteins to different actin-binding domains, such as LifeAct, utrophin and F-tractin, as well as anti-actin-nanobody technology. In addition, the compound SiR-actin and the expression of GFP–actin are also applicable for various types of live-cell analyses. Overall, the visualization of actin within a physiological context requires a careful choice of method, as well as a tight control of the amount or the expression level of a given detection probe in order to minimize its influence on endogenous actin dynamics.
Suppression of intestinal tumorigenesis in Apc mutant mice upon Musashi-1 deletion
Authors: Wolfe Andy R. , Ernlund Amanda , McGuinness William , Lehmann Carl , Carl Kaitlyn , Balmaceda Nicole , Neufeld Kristi L. 
Published: January 2017

ABSTRACT
Therapeutic strategies based on a specific oncogenic target are better justified when elimination of that particular oncogene reduces tumorigenesis in a model organism. One such oncogene, Musashi-1 (Msi-1), regulates translation of target mRNAs and is implicated in promoting tumorigenesis in the colon and other tissues. Msi-1 targets include the tumor suppressor adenomatous polyposis coli (Apc), a Wnt pathway antagonist lost in ∼80% of all colorectal cancers. Cell culture experiments have established that Msi-1 is a Wnt target, thus positioning Msi-1 and Apc as mutual antagonists in a mutually repressive feedback loop. Here, we report that intestines from mice lacking Msi-1 display aberrant Apc and Msi-1 mutually repressive feedback, reduced Wnt and Notch signaling, decreased proliferation, and changes in stem cell populations, features predicted to suppress tumorigenesis. Indeed, mice with germline Apc mutations (ApcMin) or with the Apc1322T truncation mutation have a dramatic reduction in intestinal polyp number when Msi-1 is deleted. Taken together, these results provide genetic evidence that Msi-1 contributes to intestinal tumorigenesis driven by Apc loss, and validate the pursuit of Msi-1 inhibitors as chemo-prevention agents to reduce tumor burden.
O uso de simuladores via smartphone no ensino de física: O experimento de Oersted
Authors: Barbosa Cairo Dias , Gomes Luiz Moreira , Chagas Maria Liduina das , Ferreira Fernanda Carla Lima 
Published: January 2017

Neste trabalho abordam-se aspectos teóricos de metodologias direcionadas para aplicação de simulações via smartphones voltadas para temas do Eletromagnetismo no Ensino Médio. Para atingir esse objetivo, são apresentadas propostas de como trabalhar através de smartphones o simulador “Oersted” desenvolvido pelo Sistema Brasileiro de Ensino S. A. (SBE) disponibilizado gratuitamente no Play Store. Através do aplicativo é possível ao aluno interagir com a simulação de um dos experimentos mais importantes da Física, que promoveu a união entre a Eletricidade e o Magnetismo. Acredita-se que o uso de simulações através de smartphones no ensino, orientadas de forma pedagógica pode tornar estes aparelhos uma espécie de laboratório virtual portátil nas aulas de Física e ampliar as possibilidades de produzir ganhos na aprendizagem dos estudantes.