bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of First-generation College Students in Saudi Universities
Authors: Alshrief Samah 
Published: October 2024

Abstract

This study explores the characteristics and experiences of first-generation college students in Saudi Arabia, addressing a gap in the literature on this demographic within the context of Saudi higher education. Historically, the Alhejaz region (Mecca Province) enjoyed privileged access to educational institutions, while other regions faced significant barriers. Since the founding of Saudi Arabia in 1932 and the subsequent educational reforms, access to higher education has expanded significantly, with 37 public and 29 private institutions now operating across the nation's 13 provinces. This expansion has allowed students from previously underserved regions to pursue higher education, leading to a rising population of first-generation college students. By examining the demographic characteristics, geographical backgrounds, and aspirations of first-generation students, this quantitative study aims to provide an understanding of First-generation College Students in Saudi Arabia.
Facilitator suggestions to increase cultural relevance of an evidence-based intervention: A qualitative analysis
Authors: Combs Katie , Ladika Amanda , Goldberg Veronica , Hubler Brittany , Steeger Christine , Stacey Lore , Zaugg Sophia , Lain Marion Amanda 
Published: October 2024

Abstract

Background. Once an intervention is deemed “evidence-based,” it is often disseminated across contexts, settings, and populations beyond those originally tested. The cultural relevance or “fit” of an evidence-based intervention (EBI) in diverse local contexts is a debated topic, but few studies have explored facilitators' perceptions. This study examines facilitators' suggestions for improving the cultural relevance of a universal preventive EBI widely disseminated in middle schools for over 30 years.
Method. Using process evaluation data from a dissemination project (2019-2022) in 363 schools across 16 US states, 566 open-ended responses from EBI facilitators were analyzed using the Framework Method (i.e., a content analysis approach).
Results. Five broad themes emerged among 758 unique suggestions: 1) social or technological relevance (52% of codes), 2) teacher or school-related considerations (13% of codes), 3) student engagement (10% of codes), 4) adaptations for diverse students (9% of codes), and 5) curriculum mechanics (4% of codes). Facilitators overwhelmingly suggested improving cultural relevance by updating social and technological aspects to reflect current trends in substance use, youth culture, and implementation.
Discussion. The study underscores a component of cultural relevance that is particularly relevant to on-the-ground implementers. Feasible ways for EBIs to stay current on social trends and technology to reflect evolving trends in risk behaviors, youth culture, and implementation are essential to increase or maintain the cultural relevance of an EBI. Addressing these areas is crucial for enhancing the long-term adoption, fidelity, and effectiveness of EBIs across diverse populations and evolving cultural landscapes.
Construction of pancreatic cancer cell lines resistant to Albumin Paclitaxel plus Gemcitabine combined regimen and screening of chemoresistance genes for exploring targeted therapy
Authors: Li Zeru , Qin Cheng , Yang Xiaoying , Zhao Bangbo , Li Tianyu , Zhao Yutong , Zhang Xiangyu , Wang Weibin 
Published: October 2024

Abstract

Pancreatic cancer (PCa) is a solid tumor with extremely high malignancy and poor prognosis. Chemotherapy is an important treatment option. Compared with gemcitabine alone, albumin paclitaxel plus gemcitabine (AG) is more effective in the treatment of advanced PCa. The NCCN guidelines also list AG regimen as one of the first-line recommended schemes for PCa. As for the mechanism of drug resistance of AG regimen, there is no relevant literature report at present. MIA PaCa-2 and BxPC-3, two PCa cell lines, were utilized to construct stable cell lines (AG-resistant cell lines) resistant to paclitaxel plus gemcitabine via gradually increased drug concentration of gemcitabine and albumin paclitaxel. AG-resistant cell lines are more malignant than parental cell lines in proliferation, invasion and chemoresistance. 5 genes, including ALDH3A1, ALDH3B1, CDA, MUC1, C15orf48 were found significantly high expression in AG-resistant cell lines. By utilizing PDB database and drugbank, a large-scale virtual screening of target drugs is carried out to screen for possible small molecule targeted drugs, and phthalocyanine was selected and proved to sensitize AG-resistant cell lines. We also validated the mechanism of phthalocyanine sensitizing chemoresistance, demonstrating that it leads to cell death by stimulating intracellular ROS level.
A study on the emotional responses on hearing laughter from brain activity measurements using near-infrared spectroscopy
Authors: Fujiwara Yoshiyasu , Okamura Hitoshi 
Published: October 2024

Abstract

Background: Studies have recognized the beneficial effects of hearing laughter. However, its mechanism has not been sufficiently investigated. Therefore, we examined how laughter influenced affect and emotions and evaluated brain activity upon hearing laughter via near-infrared spectroscopy (NIRS).
Methods: An experiment was conducted with seven healthy university students and used a block design with laughter and relaxing music as interventions. A portable brain activity measurement device (HOT-2000; NeU Corporation) was used to capture neural activity in the lateral prefrontal cortex, based on the degree of changes in total hemoglobin (Hb).
Results: Comparison of the blood flow volume between the right and left prefrontal lateral cortices after each intervention revealed a significant difference in total Hb; however, this was only at rest. No differences were observed during either the laughter or music intervention. Furthermore, comparison of the cerebral blood flow volume between the three experimental conditions (rest period, laughter, music) revealed a significant difference (p = 0.016) between rest period and laughter. However, no significant difference was observed between the other factors.
Discussion: The results did not provide substantial insights into the affect and emotions during laughter interventions based on the degree of change in total Hb between the right and left lateral prefrontal cortices. However, hearing laughter brought about changes in mental states, such as feelings of pleasure and calm, which suggested that hearing laughter relaxed brain activity.
SIRT3, a New Hope in Liver Diseases from Pathogenic Mechanisms to Therapeutic Strategies
Authors: Tan Sai-Ya , Chen Xiao-Xuan , Zhang Rui , Liu Pan , Wang Jian-Peng , Wang Ting , Xiong Zhang-E 
Published: October 2024

Abstract:
The liver, the largest internal organ in the human body, regulates multiple reactions
and processes, including detoxification, regeneration, and immune defense. Liver diseases have
emerged as a significant global public health issue. Numerous studies have indicated that the
mitochondrial deacetylase SIRT3 has played various roles in the pathogenesis and pathological
progression of liver diseases.

Objectives:
This review aims to explore the advances in the study of SIRT3 and liver disease and
review possible mechanisms. Natural and chemical activators of SIRT3 are also discussed. The
role of SIRT3 in the pathogenic mechanisms and therapeutic strategies of liver disease is summarized
by reviewing Pubmed. SIRT3 alleviates liver diseases by regulating fatty acid metabolism,
mitochondrial function, and immune-inflammatory response. Meanwhile, Withaferin A,
lipoic acid, major royal jelly proteins, and berberine can activate SIRT3 or upregulate its expression,
thereby alleviating liver damage. SIRT3 can effectively slow down the progression of liver
disease and protect the liver from further damage. The use of SIRT3 as a pharmacological target
for the treatment of liver disease is a potential therapeutic approach.
Promising Anti-Inflammatory Properties of Ursolic Acid Isolated from Atylosia goensis
Authors: Varghese Leemol , Banu Shanaz 
Published: October 2024

Introduction:
Indigenous plants are plant species that are native to a specific region
and have evolved naturally and adapted to local environmental conditions over a long period.

Aim:
This study aimed to explore the anti-arthritic effects of Atylosia goensis, an indigenous plant
species in the Western Ghats of India.

Methodology:
An ethanolic extract of Atylosia goensis was obtained using the Soxhlet extraction
method, which revealed a diverse array of phytochemicals through liquid chromatography-mass
spectroscopy (LC-MS). Key compounds, including fatty acids, sterols, and potential health-beneficial
compounds, were identified, and one prominent phytoconstituent, ursolic acid, was spectroscopically
characterized using 1H NMR, 13C NMR, and mass spectrometry. The research also examined
the anti-inflammatory activity and in-vitro and in-vivo anti-arthritic activity of ethanolic
extract.

Results:
The ethanol extract exhibited notable inhibition of Cox-2, indicating potential anti-inflammatory
effects. The in vivo anti-arthritic activity of ursolic acid was evaluated at different doses
(200 and 400 mg/kg) over a 24-day period. Ursolic acid significantly reduced joint edema, particularly
at higher doses, thereby emphasizing its anti-inflammatory properties. Biomarker analysis revealed
dose-dependent attenuation of disease-associated biomarker levels, supporting the potential
therapeutic efficacy of ursolic acid in arthritis management. Moreover, the hepatoprotective potential
of ursolic acid was evident in biochemical parameters, including SGPT, SGOT, and ALP levels.
Both doses of ursolic acid effectively mitigated liver dysfunction induced in the disease control
group, demonstrating its protective role in liver health. Histopathological assessments corroborated
these findings, indicating a reduction in inflammatory areas following ursolic acid treatment,
especially at higher doses.

Conclusion:
This experimental work provides valuable information on the therapeutic potential of
Atylosia goensis and ursolic acid, emphasizing their roles in anti-inflammatory and hepatoprotective
applications. This study contributes to the understanding of plant-derived compounds for potential
pharmaceutical use in the management of inflammatory and arthritic conditions.
Nano-formulations for the Management of Epilepsy: Synthetic and Herbal Drug Perspectives
Authors: Shivani  , Singh Gurvirender , Narwal Smita , Balram  , Chopra Bhawna , Dhingra Ashwani K. 
Published: October 2024

Introduction:
Epilepsy is a multifaceted neurological disorder impacting many individuals
globally. Although the main treatment method is through medicines, many patients do not respond
to existing drugs. This has spurred extensive research for new therapeutic targets and drug
delivery methods. Inflammation and oxidative stress have been associated with the development
and progression of epilepsy. Nanomedicine-based treatments focussing on these pathways could
provide a promising way to enhance treatment results.

Objective:
This review aims to provide insights into enhancing antiepileptic therapy through the
development of nanoformulations of synthetic and herbal drugs.

Methods:
A comprehensive review of existing literature was conducted to evaluate the potential
of nanoformulations in improving the delivery and efficacy of antiepileptic drugs. The review covers
the pathophysiological hypotheses of epilepsy, including the glutamatergic, GABAergic, oxidative
stress, and neuroinflammation hypotheses, and examines the role of neurotransmitter imbalances
in seizure activity.

Results:
Nanoformulations offer promising advantages for epilepsy treatment by enhancing drug
delivery across the blood-brain barrier, reducing required dosages, and minimizing side effects.
The utilization of nanoparticles can improve the bioavailability and targeting of AEDs, potentially
leading to better seizure control. However, challenges such as ensuring biocompatibility and optimizing
nanoparticle characteristics remain.

Conclusion:
While significant progress has been made in understanding epilepsy and developing
treatments, the disorder continues to pose challenges. Nanoformulations represent a promising
area of research that could lead to more effective and targeted therapies for epilepsy, although further
studies are needed to address the associated challenges and fully realize their potential.
Over-the-Counter Hearing Aids Versus Traditional Hearing Aids in Patients With Mild-to-Moderate Hearing Loss: Protocol for a Noninferiority Randomized Controlled Trial
Authors: Kim Ga-Young , Jo Mini , Cho Young Sang , Moon Il Joon 
Published: October 2024

Background
With the aging of society, the prevalence of hearing loss (HL) is increasing. Currently, approximately 5% of the global population has HL, and this number is projected to reach 7 million by 2050. Although hearing aids (HAs) are the primary treatment for HL, their use is limited by barriers such as high costs and social stigma. To address these limitations, over-the-counter (OTC) HAs have been introduced, but their effectiveness and drawbacks require further investigation.

Objective
This study aims to conduct a noninferiority randomized controlled trial comparing OTC HAs with traditional HAs to assess the clinical effectiveness of OTC HAs.

Methods
We designed a noninferiority randomized controlled trial comparing OTC HAs and traditional HAs in adults with mild-to-moderate HL. A total of 64 participants (32 per group) will be recruited. Randomization will be performed using block randomization (block sizes of 2 or 4) with an equal allocation ratio. The study will include 2 types of HAs: an OTC HA (Jabra Enhance Pro) and a traditional HA (LiNX Quattro LE561-DRW) by GN ReSound A/S. OTC HAs will be self-fitted using a smartphone app, while traditional HAs will be fitted by a licensed audiologist using the National Acoustics Laboratories–Non-Linear Prescription, second generation. Assessments, including functional gain, real-ear measurement, speech audiometry, and questionnaires, will be conducted at 6-month intervals over the course of 3 visits. Statistical analysis will compare the 2 outcomes, focusing on functional gain, to determine noninferiority.

Results
This study is scheduled to begin in August 2024 and has not yet recruited any participants. The study will be conducted over 2 years, from August 2024 to July 2026. Each participant will have 2 follow-up visits at 6-month intervals, making the total follow-up period 1 year.

Conclusions
Since 2022, the introduction of OTC HAs has revolutionized access to these devices. Researchers, clinicians, and the general public are keen to evaluate the clinical effectiveness of OTC HAs, as more individuals will likely use them for HL. This increased usage will provide valuable real-world data to understand the benefits and limitations of OTC HAs. Monitoring the outcomes and user feedback will provide insights into their effectiveness and impact on hearing rehabilitation.

International Registered Report Identifier (IRRID)
PRR1-10.2196/59894
The Influence of Fake News, Personality of Muslim Customers and Anger Against Hateful Behavior of Muslim Consumers at Brands Halal Products With Religiosity As Moderation Variable
Authors: Warsito Chandra , Sholikhin Iin , Farhah Nida Umi , Ab. Wahab Norailis , Kurniawan Arief Adhy , Wibisono Dhika Dzulkarnain 
Published: October 2024

This study aims to determine the role of religiosity in moderating the influence of fake news variables, the personality of Muslim customers, and anger towards the hateful behavior of Muslim consumers towards halal product brands. Primary data collection was carried out by purposive sampling with a total sample of 340 response questionnaires collected from consumers of fast food restaurant outlets (Kentucky Fried Chicken, McDonald's, and Pizza Hut) domiciled in Purwokerto, Tegal, Yogyakarta, Surakarta, and Semarang. The relationship between fake news variables, Muslim customer personality, and anger towards hateful behavior towards brands were analyzed using Structural Equation Modeling from the Warp Partial Least Squares regression program package. Empirical research shows the influence of fake news, Muslim personality, and anger on brand hatred. The test results show that religiosity can be a moderating variable between fake news, Muslim personalities, and anger towards brand hate for halal products. Hatred about the brand can be suppressed if the company provides information quickly regarding the products offered, and this news can be quickly verified through social media; the information provided is straightforward to understand, and consumers are always optimistic and able to provide good perceptions so consumers do not feel they hate food and beverages and can ensure a halal product.
Desafios das startups em Florianópolis (SC): fatores que levam o empreendedor ao insucesso
Authors: Leite Eduardo Dias , Pinheiro Amanda , Brandão Luciane Gobbo , Lenzi Fernando César , Behling Gustavo 
Published: October 2024

A contribuição das startups é reconhecida, apesar de uma estratégia de alto risco, mas alta recompensa, com significativa taxa de fracassos e uma baixa proporção de sucesso. O objetivo desta pesquisa é analisar os fatores que levam o indivíduo a não ter sucesso na criação de startups localizadas na cidade de Florianópolis (SC). A metodologia utilizou a análise de conteúdo de 14 entrevistas analisada pelo Python. Os resultados apontam que as startups da região falham porque houve ausência no planejamento a longo prazo, não se adaptaram às mudanças do mercado, ocorreram problemas entre os sócios, enfrentaram a falta de recursos e os empreendedores não levaram em conta as reais necessidades do mercado, testando e adequando o seu projeto junto à comunidade e consequentemente, não ofereceram o produto/serviço e atendimento adequados ao cliente.
Palavras-chave: empreendedores; startups; insucesso.
Design and Validation of a University Education Peer Observation Tool
Authors: Domínguez-Monte José Antonio , Cenizo-Benjumea José Manuel , Gálvez-González Javier , Otero-Saborido Fernando Manuel 
Published: October 2024

Objective: The aim of this study was to design and validate a university education PoT instrument.

Theoretical Framework: It has become a priority to implement Peer Observation of Teaching (PoT) in the domain of higher education. There are different PoT approaches, a social credentialism model and a feedback-oriented approach.

Method: The Higher Education-PoT (HE-PoT) tool was designed ad hoc following observational methodology principles. The original items were drawn from a systematic review of PoT tools by Otero-Saborido et al. (2024). The procedure consisted of two phases: in the first qualitative phase, items from the tool were selected and circulated within a group of experts; in the second quantitative phase, the items were quantified using the Aiken coefficient

Results and Discussion: It was initially based on a systematic review of PoT tools and subsequently subjected to 4 rounds of revisions by Physical Education and Sports Science teaching experts. The final tool consisted of a total of 33 descriptive categories divided into 11 items. The validity of all item contents was calculated using Aiken's coefficient (value equal to 0.75 or above, except for 2 items which scored 0.66) and all categories obtained values above 0.75. A total of 25 of the 33 categories presented values over 0.90.

Research Implications: Future works should test the tool reliability so that it can be used to improve teaching following collaborative approaches.

Originality/Value: Validated PoT tools are generally lacking in university education. The designed tool includes a number of items that contribute to a sustainable observation for teachers.
Systematic Review on Sustainable Intensification Strategies in Brazilian Beef Production
Authors: Cardoso Edilene Virgulina , Gimenes Régio Márcio Toesca 
Published: October 2024

Objective: To analyze studies on sustainable intensification strategies in beef production in Brazil, focusing on carbon neutralization and sustainable practices.

Theoretical Framework: Addresses the relationship between livestock and environmental impacts such as deforestation and greenhouse gas emissions. It explores alternatives for pasture recovery and optimized management.

Method: The Web of Science and Scopus databases were used to identify and select studies. Strict inclusion and exclusion criteria were applied to choose 31 relevant articles, which were used to systematize current knowledge. The PRISMA Protocol (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) was used for the systematic literature review. The PRISMA 2020 Flow Diagram serves as a support tool for researchers in organizing the essential steps to conduct the systematic review.

Results and Discussion: The studies highlight the importance of strategies such as sustainable intensification and crop-livestock-forest integration to mitigate environmental impacts. They reveal the evolution of the terms used and the importance of public policies and technologies to mitigate emissions and promote more sustainable practices.

Research Implications: Contributes to the formulation of sustainable policies and practices, reinforcing the need for integrated approaches that consider economic and environmental factors in beef production.

Originality/Value: Provides an updated and critical synthesis on the topic of sustainable beef and carbon neutralization, indicating gaps and opportunities for future research and policy interventions.
Are variations in ventricular catheter placement related to design of the catheter? A single-center cohort study
Authors: Harland Emily , Oh Justin , Protas Matthew , Krishnamurthy Satish 
Published: October 2024

Background:
The use of intracranial catheters is a common procedure used for neurosurgical patients with a variety of pathologies. Despite its frequency of use, shunt failure and revision have been reported to be a common problem. Given that depth of insertion can significantly affect the catheter tip position, a single institution retrospective chart review was performed to examine the accuracy of shunt and external ventricular drain (EVD) placement.

Methods:
Computed tomography (CT) images of the head following shunt or ventriculostomy insertion were analyzed to determine the delta between the final length of the intracranial catheter and the intended depth described in the operative notes.

Results:
We found that there was a statistically significant difference in the accuracy of placement when comparing EVDs to shunts. The most used EVDs at our institution are marked with a solid black line in increments spaced 2 cm apart. The most used ventricular shunt catheter has a marking at 5 cm and 10 cm from the tip of the catheter. We believe that the visual confirmation that is afforded by metric unit markings on the EVD allows for better final placement of the catheter at the outer table of the calvarium.

Conclusion:
The addition of regular millimeter metric unit markings by the manufacturer is imperative in decreasing the chances of error in the insertion of ventricular catheters and preventing potential neurovascular injury to the surrounding structures.