bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cetuximab and Radiotherapy Versus Cisplatin and Radiotherapy for Locally Advanced Head and Neck Cancer: A Randomized Phase II Trial
Authors: Magrini Stefano Maria , Buglione Michela , Corvò Renzo , Pirtoli Luigi , Paiar Fabiola , Ponticelli Pietro , Petrucci Alessia , Bacigalupo Almalina , Crociani Monica , Lastrucci Luciana , Vecchio Stefania , Bonomo Pierluigi , Pasinetti Nadia , Triggiani Luca , Cavagnini Roberta , Costa Loredana , Tonoli Sandro , Maddalo Marta , Grisanti Salvatore 
Published: December 2015

Purpose No randomized trials have been conducted to directly compare radiotherapy (RT) with concomitant cisplatin (CDDP) versus concomitant cetuximab (CTX) as first-line treatment of locally advanced squamous cell carcinoma of the head and neck. In this randomized trial, we compared these two treatment regimens in terms of compliance, toxicity, and efficacy. Patients and Methods Eligible patients were randomly assigned in a 1:1 ratio to receive either CDDP 40 mg/m2 once per week or CTX 400 mg/m2 as loading dose followed by CTX 250 mg/m2 once per week concomitant to radical RT. For primary end points, compliance to treatment was defined as number of days of treatment discontinuation and drug dosage reduction. The acute toxicity rate was defined according to the National Cancer Institute Common Toxicity Criteria. Efficacy end points were local recurrence-free survival, metastasis-free survival, cancer-specific survival, and overall survival. Results The study was discontinued early because of slow accrual after the enrollment of 70 patients. RT discontinuation for more than 10 days occurred in 13% of patients given CTX and 0% given CDDP (P = .05). Drug dosage reduction occurred in 34% given CTX and 53% given CDDP (difference not significant). Toxicity profiles differed between the two arms, with hematologic, renal, and GI toxicities more frequent in the CDDP arm, and cutaneous toxicity and the need for nutritional support more frequent in the CTX arm. Serious adverse events related to treatment, including four versus one toxic deaths, were higher in the CTX arm (19% v 3%, P = .044). Locoregional control, patterns of failure, and survivals were similar between the treatment arms. Conclusion CTX concomitant to RT lowered compliance and increased acute toxicity rates. Efficacy outcomes were similar in both arms. These results raise the issue of appropriately selecting patients with head and neck cancer who can benefit from CTX in combination with RT.
Features Regarding the Migration Situation in the Territories of Advanced Development in the Far East
Authors: Рязанцева  , Ryazantseva Margarita , Якушова  , Yakushova E. 
Published: December 2015

The article examines the factors influencing human resources software features advanced development areas created by the Far Eastern Federal District. The
authors reveal the basic characteristics of these areas shows the average population of the subject and the number of jobs. The article analyzes the problems
of security of territories of priority development of the Far Eastern Federal District human resources. The authors also considered the possibility of attracting
in the region of foreign labor. It is shown that the strategy of development of the Far East should be implemented in conjunction with a comprehensive
strategy for labor mobility. The results of the analysis of the dynamics of the labor force in the region, which indicate the existing problems in the region. The
features of the migration situation in the region. Estimated value for the development of the region’s labor migration from abroad.
Discipline or Disruption? Stakeholder Relationships and the Effect of Takeover Threat
Authors: Cen Ling , Dasgupta Sudipto , Sen Rik 
Published: December 2015

Although a sizable literature suggests that firms benefit from vulnerability to takeovers because it reduces agency problems, the threat of takeovers can also impose ex ante costs on firms by adversely affecting relationships with important stakeholders, such as major customers. We find that when firms have corporate customers as important stakeholders, an exogenous reduction in the threat of takeovers increases their ability to attract new customers and strengthens their relationships with existing customers, resulting in improvement in operating performance. The positive effect on operating performance is greater for suppliers that are likely to offer unique and durable products to their customers. Our results suggest a beneficial aspect of protection from takeovers when stakeholder relationships are important. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2252 . This paper was accepted by Wei Jiang, finance.
‘The theme of psychological destruction’: Horror stars, the crisis of identity and 1940s horror
Authors: Jancovich Mark 
Published: December 2015

Abstract
This article presents an analysis of horror stars of the 1940s, particularly Lon Chaney Jr, Laird Cregar, Lionel Atwill and George Zucco, and argues not only that these stars demonstrate the linkage between the figures of the horror monster and/or villain, the gangster and the spy, particularly the Nazi spy, but also that this linkage was due to their supposedly shared psychological characteristics. These films are preoccupied with the themes of psychological domination and submission, in which both the villain and his victim experience a crisis of subjectivity in which they no longer seem to be the author of their own actions, and in which their actions seem to be the effect of forces over which they have no control, forces that challenge any sense of clear division between the internal and the external, the self and the other. In this way, these films not only challenge the common linear and teleological history of the horror film but also the sense of 1940s Hollywood cinema as straightforwardly affirmative. In other words, these films demonstrate a profound sense of ontological insecurity within the period, however much the films might try to counter this insecurity.
New discoveries on astronomical orientation of Inca site in Ollantaytambo, Peru
Authors: Hanzalová Karolína , Klokočník Jaroslav , Kostelecký Jan 
Published: December 2015

<p>This paper deals with astronomical orientation of Incas objects in Ollantaytambo, which is located about 35 km southeast from Machu Picchu, about 40 km northwest from Cusco, and lies in the Urubamba valley. Everybody writing about Ollantaytambo, shoud read Protzen. (1) He devoted his monograph to description and interpretation of that locality. Book of Salazar and Salazar (2) deals, among others, with the orientation of objects in Ollantaytambo with respect to the cardinal direction. Zawaski and Malville (3) documented astronomical context of major monuments of nine sites in Peru, including Ollantaytambo. We tested astronomical orientation in these places and confirm or disprove hypothesis about purpose of Incas objects. For assessment orientation of objects we used our measurements and also satellite images on Google Earth and digital elevation model from ASTER. The satellite images were used to estimate the astronomical-solar-solstice orientation, together with terrestrial images from Salazar and Salazar (2). The digital elevation model is useful in the mountains, where we need the actual horizon for a calculation of sunset and sunrise on specific days (solstices), which were for Incas people very important. We tested which astronomical phenomenon is connected with objects in Ollantaytambo. First, we focused on Temple of the Sun, also known the Wall of six monoliths. We tested winter solstice sunrise and the rides of the Pleiades for the epochs 2000, 1500 and 1000 A.D. According with our results the Temple isn´t connected neither with winter solstice sunrise nor with the Pleiades. Then we tested also winter solstice sunset. We tried to use the line from an observation point near ruins of the Temple of Sun, to west-north, in direction to sunset. The astronomical azimuth from this point was about 5° less then we need. From this results we found, that is possible to find another observation point. By Salazar and Salazar (2) we found observation point at the corner (east rectangle) of the pyramid by <em>Pacaritanpu,</em> down by the riverside. There is a line connecting the east rectangular “platform” at the river, going along the Inca road up to vicinity of the Temple of the Sun and then in the direction to the Inca face. Using a digital elevation model we found the astronomical azimuth, which is needed for confirm astronomical orientation of the Temple. So, finally we are able to demonstrate a possibility of the solar-solstice orientation in Ollantaytambo.</p>
Women's opinions about mate choices: A qualitative study<p>Kadınların eş seçimleri hakkındaki görüşleri: Nitel bir çalışma
Authors: Usluoğlu Feyruz , Atıcı Meral , Vurgeç Avcıbay Burcu 
Published: December 2015

<p>The purpose of this study was to identify the preferences of women's opinions on the choice of a mate. Participants of the study were 15 women who work in different jobs in several health agencies. Interviews were used as a qualitative research method to collect personal/detailed data from participants. Qualitative data obtained from participants were analysed by the content analysis method. Results showed that the majority of women prefer to get married men who are older than themselves and averaged in physical appearance. It was identified that honesty is the most desired personality characteristic for women when choosing a partner, followed by, in order: assertiveness, respect and understanding. Women in the study admitted that they prefer men with different personality characteristics and social status from those of theirs and also prefer men who have an income level and social status similar to or higher than their own. Caring and loving father themes were identified in terms of women expectation from their partner. According to the participants’ views there should be a coherence between their personal hobbies and culture and those of their partners. Women emphasised that they want their partner to have a respectful, genuine, close and good relationship with their family. Results are discussed in the light of related literature.</p><div> </div><div> </div><div><strong>Özet</strong></div><div><strong></strong><p>Bu araştırmada, kadınların eş seçimine ilişkin görüşleri incelenmiştir. Çalışmaya sağlık alanında çalışan farklı meslek grubundan 15 kadın alınmıştır. Araştırmada veriler nitel veri toplama yöntemlerinden görüşme yöntemi kullanılarak toplanmış ve görüşmelerden elde edilen nitel verilerin analizinde içerik analizi yöntemi kullanılmıştır. Araştırmanın bulgularına göre kadınlar evlenmek istedikleri kişinin yaşının kendi yaşlarından büyük olmasını, ortalama fiziksel özelliklere sahip olmasını tercih etmektedir. Kadınların en çok aradığı kişilik özelliği dürüstlük olmuştur ve bunu sırasıyla girişken, saygılı ve anlayışlı olma izlemiştir. Kadınlar evlenmek istedikleri kişinin kişilik özellikleri ve sosyal statü teması altında gruplanan özellikler açısından kendilerinden farklı olmasını, en çok ilgili ve sevecen temaları altında belirtilen babalık özelliklerine sahip olmasını istediklerini belirtmişlerdir. Evlenmek istenilen kişinin kendileriyle benzer ya da daha yüksek ekonomik gelir ve statüye sahip olmasını, kişisel zevkler ve kültürel temalara ilişkin konularda uyumlu olmayı bekledikleri belirtilmiştir. Ayrıca kadınlar, evlenmek istedikleri kişinin aileleriyle saygılı, yakın, samimi ve iyi bir ilişkisi olmasını istediklerini, ailenin kültürel uyum, sosyal statü ve kişilik özellikleri temaları kapsamındaki nitelikler konusunda eş seçimini etkilediğini ifade etmişlerdir. Araştırma bulguları, ilgili literatür doğrultusunda tartışılmıştır.</p></div>
Simulation of calcium acetylide and acetylene production
Authors: Oršula Igor , Lehocký Miroslav , Steltenpohl Pavol 
Published: December 2015

Abstract
Design simulation of a reactor for acetylene production from calcium acetylide and its purification in the gaseous phase is presented. Simulations were performed using the program ASPEN+ which is a very flexible and useful tool for the simulation and optimization of various types of chemical technologies including gas-liquid-solid systems. The first step of the acetylene synthesis, based on coal as the raw material, is the production of calcium acetylide. This substance is obtained from coke and limestone in an electric arc furnace at elevated temperatures. Raw materials used in this process contain relatively large amounts of impurities that are converted and entrapped in the desired product of the above reaction. Some of the impurities, e.g. metallic iron or its alloys, can be separated easily. However, most of the other elements present in the form of their compounds with calcium remain a part of “technical grade” calcium acetylide. Acetylene is commercially produced by the reaction of “technical grade” calcium acetylide with water under controlled reaction conditions in an inert atmosphere. Depending on the purity of calcium acetylide used, the produced raw acetylene contains a variety of admixtures that lower its quality. As a consequence, prior to its expedition to the customer, raw acetylene should be submitted to a down-stream processing that consists of the separation of basic and acidic pollutants present in acetylene by absorption. The final processing step is adsorption and/or freezing-out of water vapor from the purified acetylene stream. Besides acetylene, the reaction of calcium acetylide with an excess of water provides aqueous calcium hydroxide. In order to commercialize this byproduct, the content of water in the mixture should be lowered to the required level. In this contribution, development of a model of calcium acetylide and acetylene production as well as the simulation of these processes in ASPEN+ are presented. Simulation results of a realistic production line model correlate very well with the actual data from the technology used in Fortischem, a.s., Novaky, Slovakia.
Photocleavage of pDNA by bis-imidazolidino and bis-thioureido proflavines
Authors: Cisárikováa Alžbeta , Abaffy Pavel , Imrich Ján , Paulíková Helena 
Published: December 2015

Abstract
New photosensitizers are needed for photodynamic antimicrobial and anticancer chemotherapy. Two new groups of proflavine derivatives have been recently prepared and their action on the cancer cells has been investigated by our research team. In this paper, we studied an effect of UV-A irradiation of two groups of proflavines: 3,6-bis((1-alkyl-5-oxo-imidazolidin-2-yliden)imino)acridine hydrochlorides (AcrDIMs) and 1’,1”-(acridin-3,6-diyl)-3’,3”-dialkyldithiourea hydrochlorides (AcrDTUs) on a plasmid DNA (pDNA). These compounds induced a photocleavage of pDNA characteristic by generation of free radicals, single strand DNA breaks and formation of an open circular form of pDNA.
Production of galacto-oligosaccharides by commercial preparates of fungal β-galactosidase
Authors: Tokošová Silvia , Hronská Helena , Rosenberg Michal 
Published: December 2015

Abstract
Three different fungal b-galactosidases, from three commercial sources, were studied for their capacity to produce galacto-oligosaccharides by trans-galactosylation from lactose. The enzymes were investigated in a soluble form for the GOS production at two concentrations of lactose (10 % and 30 % w/w). The maximum of GOS concentration (70.9 g · L-1) was obtained at 30 % of the initial lactose (pH 4.5, temperature 30 ℃) in the second hour of enzyme reaction. The GOS yield (24 % w/w) was not significantly affected by the process of immobilisation in comparison with the free enzyme preparation (22 % w/w), but time to obtain a maximal GOS concentration was prolonged. Galacto-oligosaccharides were effectively produced by immobilised β-galactosidase in the 15 repeated batch runs of 30 % (w/w) of lactose as the substrate.
Antioxidant activity of ginger extract and identification of its active components
Authors: Mošovská Silvia , Nováková Dominika , Kaliňák Michal 
Published: December 2015

Abstract
The object of presented study was the evaluation of antioxidant activity of extract from Zingiber officinale. A method for the preparation of the extract was chosen, which enabled to isolate mostly phenolic compounds. According to the measurements with Folin-Ciocalteu reagent, obtained extract comprised total polyphenols (181.41 mgGAE/g of extract) from which flavonoids contributed to 7.8 % (14.15 mgquercetin/g of extract). Nuclear magnetic resonance (NMR) analysis showed that the phenolic ketones were predominant in the extracts of whole phenolic compounds. According to results of two spectrophotometric methods (ABTS and DPPH test), ginger extract showed stronger ability to scavenge DPPH radical than ABTS cation radical.
Protective gloves use and work habits of non-professionals handling agricultural pesticides – a survey
Authors: Hojerová Jarmila , Beránková Martina , Peráčková Zuzana , Birbičová Simona 
Published: December 2015

Abstract
As many chemicals, also agricultural pesticides (APs) can be hazardous if not used safely. Under typical working conditions, the majority of exposure to the APs is through the hand-skin. Wearing appropriate gloves should be a standard practice when handling the APs. Unlike professionals, amateurs applying the APs in their gardens or vineyards are not trained for the workplace hygiene. In this survey conducted in the spring 2015 across the Slovak Republic, practices regarding the use of protective gloves were obtained. 520 copies of the “paper-and-pencil” questionnaire were distributed to amateur users and specialized stores selling the APs (return rate of 59 %). A set of ten questions a “closed-ended” or “multiple-choice” type was offered. 75 % of respondents wear gloves when handling the APs. Regrettably, among users wearing gloves, 58 % use the same disposable gloves repeatedly, 67 % wear the reusable gloves from last season, and 53 % do not wash outside of the reusable gloves with detergent before removing them. 30 % of glove users wear all available gloves including absolutely inappropriate materials like fabric and leather, 28 % do not recognize the glove material which they use, 20 % use disposable Latex and 3 % Vinyl and Polyethylene gloves. Only 19 % of glove users wear a material that is generally considered a good choice for handling the APs (7 % Neoprene & Latex, 5 % Neoprene, 5 % Nitrile, and 2 % Butyl rubber). The survey showed the need for better education about adequate protective gloves not only for amateur users but also for retailers selling the APs and protective equipment.
Fermentation of milk- and water-based amaranth mashes
Authors: Matejčeková Zuzana , Liptáková Denisa , Valík Ľubomír 
Published: December 2015

Abstract
Growth dynamics of lactic acid bacteria (LAB) of the culture Fresco DVS 1010 and Lactobacillus rhamnosus GG in milk- and water-based amaranth mashes with sucrose or flavouring compounds (chocolate, caramel) were evaluated in this study. After fermentation that was performed at 37 ± 1 ℃ for 8 h in CO2 incubator (5 %) the products were kept at 6 ± 1 ℃ for 2 weeks. The content of proteins, lipids, reducing sugars, and starch of used amaranth flours was determined before and after expiry date, to evaluate the differences in main nutritional components. The results showed that all amaranth substrates were suitable for fermentation as the LAB levels from 108 to 109 CFU · ml-1 were reached and the levels higher than 106 CFU · ml-1 remained during cold storage. The presence of milk compared to water had no significant impact on the growth rates of LAB under study. Sensory value of flavoured amaranth mashes after the 8 h fermentation, and after 7 and 14 days of refrigerated storage was part this study as well. The best sensory acceptance according to the final evaluation of overall acceptability was evaluated in case of milk amaranth chocolate mash after 7 days of storage.
Utilization of parallel computing in chemical engineering
Authors: Danko Matej , Labovský Juraj , Janošovský Ján , Labovská Zuzana , Jelemenský Ľudovít 
Published: December 2015

Abstract
The main objective of the presented work was to explore the possibilities of parallel computing utilization in chemical engineering. Parallel computers and principles of parallel computing are in brief described in Introduction. The next part exposes the possibilities of parallel programming in Matlab and C# programming language environment. The next three parts provide case studies of parallel computing in chemical engineering. Each example of the benefits of HPC involves a comparison with its serial equivalents.
Removal of selected pesticides by nano zero-valent iron
Authors: Šimkovič Karol , Derco Ján , Valičková Mária 
Published: December 2015

Abstract
This paper is focused on the possibility of using iron nanoparticles (nZVI - nano zero-valent iron) to remove selected specific synthetic substances, such as hexachlorobutadiene, pentachlorobenzene, hexachlorobenzene, lindane and heptachlor. Experimental measurements were performed in order to evaluate the effectiveness of the removal of substances and their specific removal rate. Evaluation of the results shows that nanoiron NANOFER 25 is a convenient reactant for the removal of heptachlor, lindane and hexachlorobenzene; while for pentachlorbenzene and hexachlorobutadiene removal, longer contact times are necessary to achieve significant removal efficiencies.
Behavior of the guanosine monophosphate modified boron-doped diamond electrode in the presence of the pesticide alachlor
Authors: Svítková Jana , Švorc Ľubomír , Labuda Ján 
Published: December 2015

Abstract
Alachlor (ALA) has been widely used in agriculture and may act as a carcinogen and an environmental estrogen. The present work deals with chemical modification of boron-doped diamond electrode (BDDE) by guanosine monophosphate (GMP) and its study in the presence of ALA. Cyclic voltammetry and electrochemical impedance spektroscopy in the presence of the redox indicator 1 × 10-3 mol/L [Fe(CN)6]3-/4- together with differential pulse voltammetry of the nucleotide base were explored to test effects of GMP immobilization time, the pesticide concentrations and incubation time in the pesticide solution. It was found that GMP layer on the BDDE surface is distorted after incubation in the ALA solution.
Recent achievements and applications of solid – phase microextraction in pesticide residues analysis in food
Authors: Andraščíková Mária , Hrouzková Svetlana 
Published: December 2015

Abstract
The current trend in sample preparation methods is devoted to minimizing or eliminating the volume of extractive solvent. In this review, the focus on solid phase microextraction (SPME) as a solvent free sample preparation method for the isolation of pesticides residues in different food matrices is given. To achieve satisfactory extraction efficiency, selection of the fiber coating is an important step in the method development. Here, recent trends in new supporting materials and new fiber coatings development are discussed. Finally, applicability of SPME for the pesticide residues analysis in various food matrices using mainly chromatographic methods is also reviewed.
Pre-processing of inkjet prints NIR spectral data for principal component analysis
Authors: Oravec Michal , Gál Lukáš , Čeppan Michal 
Published: December 2015

Abstract
This paper presents a novel approach in non-destructive analysis of inkjet-printed documents. Our method is based on the combination of molecular spectroscopy in the Near Infrared Region (NIR) and a chemometric method - principal component analysis (PCA). The aim of this work was to prepare spectral data for the analysis of the interrelationships between 19 samples consisting of the same type of office paper on which black squares were full printed in black ink only. The spectra were obtained separately using the Ocean Optics System in two spectral regions, i.e., overtones: 1000-1600 nm and combination bands: 1600-2300 nm, with the paper base. Experimental results confirmed the high reliability of the proposed approach despite the sparse dataset.