bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐inflammatory effects of intranasal cyclosporine for allergic rhinitis in a mouse model
Authors: Joo Yeon‐Hee , Chang Dong‐Yeop , Kim Jin Hyun , Jung Myeong Hee , Lee Jino , Cho Hyun‐Jin , Jeon Sea‐Yuong , Kim Seong‐Jae , Kim Sang‐Wook 
Published: June 2016

BackgroundAlthough topical corticosteroids are considered a safe and effective drug for allergic rhinitis (AR), some AR patients do not show sufficient symptomatic improvement by use of topical corticosteroids. Topical cyclosporine is a safe and effective drug for patients with allergic conjunctivitis, particularly for those with steroid‐resistant allergic conjunctivitis. We investigated the anti‐inflammatory effects of intranasal cyclosporine for AR using a mouse model.MethodsAfter establishment of allergic inflammation in 5‐week‐old BALB/c mice, cyclosporine was administered intranasally 3 times per week for 2 weeks. To confirm its anti‐inflammatory effects, triamcinolone acetonide (TAC) was utilized as a control drug. Histopathologic changes were evaluated using Sirius red and Giemsa staining for eosinophilic and mast cell infiltration, respectively. The levels of cytokines in sinonasal tissues, including tumor necrosis factor (TNF), interleukin (IL)‐4, IL‐5, and IL‐13, were assessed based on a cytometric bead array.ResultsThe degree of eosinophilic infiltration was significantly decreased by instillation of cyclosporine, the potency being similar to TAC. However, the number of mast cells was not decreased by cyclosporine or TAC. The levels of TNF, IL‐4, IL‐5, and IL‐13 were significantly decreased after treatment with cyclosporine.ConclusionThe anti‐inflammatory effects of topical cyclosporine for AR were equivalent to those of topical corticosteroids. Topical cyclosporine may be useful for the treatment of AR, although human studies are required.
Effectiveness of atorvastatin in suppressing MUC5AC gene expression in human airway epithelial cells
Authors: Lee Eun Jung , Song Kee Jae , Hwang Hye Jin , Kim Kyung‐Su 
Published: June 2016

BackgroundWe recently reported that chronic cholesterol depletion in NCI‐H292 cells by lovastatin suppresses interleukin (IL)‐1β–induced MUC5AC gene expression. However, as there are numerous statins affect MUC5AC expression, we sought to determine which statin is most effective in reducing MUC5AC expression, and whether this activity of statins is related to IL‐1 receptor (IL‐1RI) and mitogen‐activated protein kinase (MAPK) activity.MethodsFour statins, namely atorvastatin, fluvastatin, lovastatin, and simvastatin, were tested. Cholesterol depletion was measured via modified microenzymatic fluorescence assay and filipin staining. NCI‐H292 cells were pretreated with 10 μM of each statin for 1 hour, 10 ng/mL of IL‐1β was added, and cells were then co‐incubated with statin and IL‐1β for 24 hours. MUC5AC mRNA expression was measured via real‐time polymerase chain reaction (PCR). The phosphorylation levels were assayed by Western blot.ResultsCholesterol in the plasma membrane was markedly decreased by all 4 statins, of which atorvastatin was the most potent. IL‐1β–induced MUC5AC messenger RNA (mRNA) expression was most significantly decreased by 10 μM atorvastatin, to 1.4 ± 0.2‐fold of the level of the untreated control group, as opposed to an increase to 4.7 ± 0.5‐fold for IL‐1β alone, and this suppression of MUC5AC expression was dose‐dependent. This decrease in MUC5AC expression by atorvastatin was mediated via the IL‐1 receptor and the MAPK pathway, including both phospho‐p38 MAPK and phospho–extracellular signal‐regulated kinase (phospho‐ERK).ConclusionThese results suggest that atorvastatin is the most potent of the assayed statins with respect to suppression of IL‐1β–induced MUC5AC mRNA expression, and may be considered as an anti‐hypersecretory agent.
Exergonic and Spontaneous Production of Radicals through Beryllium Bonds
Authors: Brea Oriana , Alkorta Ibon , Mó Otilia , Yáñez Manuel , Elguero José , Corral Inés 
Published: June 2016

AbstractHigh‐level ab initio calculations show that the formation of radicals, by the homolytic bond fission of Y−R (Y=F, OH, NH2; R=CH3, NH2, OH, F, SiH3, PH2, SH, Cl, NO) bonds is dramatically favored by the association of the molecule with BeX2 (X=H and Cl) derivatives. This finding is a consequence of two concomitant effects, the significant activation of the Y−R bond after the formation of the beryllium bond, and the huge stabilization of the F. (OH., NH2.) radical upon BeX2 attachment. In those cases where R is an electronegative group, the formation of the radicals is not only exergonic, but spontaneous.
Oxidation Reactions with Bioinspired Mononuclear Non‐Heme Metal–Oxo Complexes
Authors: Engelmann Xenia , Monte‐Pérez Inés , Ray Kallol 
Published: June 2016

AbstractThe selective functionalization of strong C−H bonds and the oxidation of water by cheap and nontoxic metals are some of the key targets of chemical research today. It has been proposed that high‐valent iron‐, manganese‐, and copper‐oxo cores are involved as reactive intermediates in important oxidation reactions performed by biological systems, thus making them attractive targets for biomimetic synthetic studies. The generation and characterization of metal–oxo model complexes of iron, manganese, and copper together with detailed reactivity studies can help in understanding how the steric and electronic properties of the metal centers modulate the reactivity of the metalloenzymes. This Review provides a focused overview of the advances in the chemistry of biomimetic high‐valent metal–oxo complexes from the last 5–10 years that can be related to our understanding of biological systems.
Metal Vacancy Ordering in an Antiperovskite Resulting in Two Modifications of Fe2SeO
Authors: Valldor Martin , Wright Taylor , Fitch Andrew , Prots Yurii 
Published: June 2016

AbstractSmall, red Fe2SeO single crystals in two modifications were obtained from a CsCl flux. The metastable α‐phase is pseudo‐tetragonal (Cmce, a=16.4492(8) Å, b=11.1392(4) Å, c=11.1392(4) Å), whereas the β‐phase is trigonal (P31, a=9.8349(4) Å, c=6.9591(4) Å)) and thermodynamically stable within a narrow temperature range. Both crystal structures were solved from twinned specimens. The enantiomers of the β‐phase appear as racemic mixtures. Selenium and oxygen form two individual interpenetrating primitive cubic lattices, giving a bcc packing. A quasi‐octahedrally coordinated iron atom is found close to the center of each surface of the selenium sublattice. The difference between the α‐ and β‐phases is the distribution of iron at 2/3 of the surfaces. α‐ and β‐Fe2SeO are comparable with metal‐vacancy‐ordered antiperovskites. Each Fe/O lattice can also be described in terms of vertex‐sharing OFe4 tetrahedra, with a crystal structure similar to that of an antisilicate. Iron is divalent and has a high‐spin d6 (S=2) configuration. The β‐phase exhibits magnetoelectric coupling.
Azo Polymer Janus Particles Possessing Photodeformable and Magnetic‐Field‐Responsive Dual Functions
Authors: Zhou Xinran , Du Yi , Wang Xiaogong 
Published: June 2016

AbstractIt is of great fundamental and practical significance to endow Janus particles with various field‐responsive properties. In this study, a new strategy with a wide range of application possibilities is developed to fabricate JPs composed of a methacrylate‐based azo polymer, polystyrene, and Fe3O4 nanoparticles. The JPs are obtained through microphase separation in a confined volume of the dispersed droplets. The azo polymer and PS are incorporated in JPs in a core‐compartmentalized manner, and Fe3O4 are proved to exist in the azo polymer phase. The JPs show responsive movement in the magnetic field and can be easily oriented with the help of the field. By variation of the intersection angle between the particle symmetrical axis and the polarization direction of the linearly polarized laser beam, different deformation modes are feasibly achieved for the JPs. By exploiting the dual‐responsive properties, JPs with designed shapes can be fabricated by exposing the JPs to linearly polarized light.
Elucidation of the interaction of human serum albumin with anti‐cancer sipholane triterpenoid from the Red Sea sponge
Authors: Ali Mohd. Sajid , Amina Musarat , Al‐Lohedan Hamad A. , Al Musayeib Nawal M. 
Published: June 2016

AbstractA sipholane triterpenoid, named sipholenone A, with anti‐cancer properties was isolated from the Red Sea sponge Siphonochalina siphonella and characterized by proton and carbon‐13 nuclear magnetic resonance (1H NMR and 13C NMR) spectroscopies. The goal of this study was to visualize the binding of this triterpenoid with human serum albumin (HSA) and to determine its binding site on the biomacromolecule. The interaction was visualized using fluorescence quenching, synchronous fluorescence, far‐ and near‐UV circular dichroism (CD), UV–visible and Fourier transform‐infrared (FT‐IR) spectroscopies. UV–visible spectroscopy indicated the formation of a ground‐state complex as a result of the interaction. Sipholenone A quenches the fluorescence of HSA via a static quenching mechanism. A small blue shift in the fluorescence quenching profiles suggested the involvement of hydrophobic forces in the interaction. Sipholenone A binding takes place at site I of subdomain II A with a 1:1 binding ratio, as revealed by displacement binding studies using warfarin, ibuprofen and digitoxin. Far‐UV CD and FT‐IR studies showed that the binding of sipholenone A to HSA also had a small effect on the protein's secondary structure with a slight decrease in the α‐helical content. Several thermodynamic parameters were calculated, along with Forster's radiative energy transfer analysis.
Quantification of lipid modified estrogenic derivative (ESC8) in rat plasma by LC‐MS: application to a pharmacokinetic study
Authors: Ahmad Ajaz , Mondal Sujan Kumar , Jan Basit Latief , Mukhopadhyay Debabrata , Banerjee Rajkumar , Alkharfy Khalid M. 
Published: June 2016

AbstractA lipid‐conjugated, estrogenic derivative molecule, ESC8, compared with other estrogenic molecules, encourages cell death in both ER‐positive and ER‐negative breast cancer cells. A rapid and highly sensitive assay method has been developed and validated for the estimation of a ESC8 in rat plasma using liquid chromatography coupled with mass spectrometry under positive‐ion mode with electrospray ionization. The sample process includes using methanol for precipitation of ESC8 and dextromethorphan (internal standard, IS) from plasma. Chromatographic separation was achieved with methanol–water–formic acid (70:30:0.1% v/v/v) pumped at a flow rate of 0.3mL/min and a C18 column (50 × 2.1 mm i.d., 1.7 μm particle size) with a total run time of 5 min. The m/z ions monitored were 568.5 and 272.1 for ESC8 and IS, respectively. The lower limit of quantitation achieved was 1.08 ng/mL and linearity was observed from 5 to 500 ng/mL. The intra‐ and inter‐day precisions were <4%. The proposed method was successfully applied to a preliminary pharmacokinetic study of ESC8 liposomal formulation following an intraperitoneal administration of 3.67 mg/kg in rats. The concentrations of ESC8 in plasma were quantifiable up to 36 h. The peak concentration of ESC8 was found to be 110.72 ng/mL, the area under the concentration–time curve was 1625.23ng/mL h and the half‐life was 11.72 h.
Computational simulations in coronary bifurcations: Paving the future of interventional planning
Authors: Collet Carlos , Serruys Patrick W. 
Published: June 2016

Key Points

Anatomical evaluation is of paramount importance in the treatment of bifurcation lesions.
Left main coronary artery bifurcation geometry differs from left anterior descending artery/diagonal and circumflex artery/obtuse marginal bifurcations.
Individualized approach with pre‐procedural planning has the potential to improve outcomes after bifurcation treatment.
To aspirate or not!: The question may be not if, but when
Authors: Tommaso Carl L. 
Published: June 2016

Key Points

Current guidelines indicate that routine aspiration thrombectomy (AT) has a level III indication and AT is only indicated for “bail‐out” indications.
“Bail‐out” situations are not well defined.
The AT catheter may still be necessary and have other uses such as distal contrast or drug delivery.
Supramolecular Reaggregation of Acetyl Salicylic Acid‐4,4′Dipyridyl Cocrystals from Salicylic Acid‐4,4′Dipyridyl Cocrystals
Authors: Lee Kyeong‐Sill , Kim Kwang‐Joo , Ulrich Joachim 
Published: June 2016

AbstractScreening of the change mechanism of salicylic acid‐4,4′dipyridyl (SAA‐4,4′dipy) cocrystals to acetyl salicylic acid‐4,4′dipyridyl (ASA‐4,4′dipy) cocrystals was performed and their transformation investigated. Cocrystals of SAA‐4,4′dipy are concomitantly formed in ASA/4,4′dipyridyl/ethanol solutions, resulting from ASA decomposition. Eventually, cocrystals of ASA‐4,4′dipy are obtained from a sequence of in situ reactions by controlling the operating conditions. Both cocrystals have the same hydrogen bonding interaction between the drug molecules. The ketene functional group decomposed in salicylic acid cocrystal formation reaggregates during solution‐mediated cocrystallization that leads to the formation of ASA cocrystals.
A Valence Tautomeric Dinuclear Copper Tetrakisguanidine Complex
Authors: Wiesner Sven , Wagner Arne , Kaifer Elisabeth , Himmel Hans‐Jörg 
Published: June 2016

AbstractWe report on the first valence tautomeric dinuclear copper complex, featuring 2,3,5,6‐tetrakis(tetramethylguanidino)pyridine as a bridging redox‐active GFA (guanidino‐functionalized aromatic) ligand. The preferred electronic structure of the complex is massively influenced by the environment. In the solid state and in nonpolar solvents a paramagnetic, dinuclear CuII complex with a neutral GFA ligand is present. In polar solvents, the electronic structure changes to a diamagnetic, dinuclear CuI complex with a twofold‐oxidized GFA ligand. Using acetone as a solvent, both electronic structures are accessible due to a temperature‐dependent equilibrium between the two valence tautomeric complexes. Our results pave the way for a broader use of valence tautomeric transition‐metal complexes in catalytic reactions since anionic coligands can now be tolerated owing to the neutral/positively charged GFA ligand.
Copper(II) and Zinc(II) Complexes of Conformationally Constrained Polyazamacrocycles as Efficient Catalysts for RNA Model Substrate Cleavage in Aqueous Solution at Physiological pH
Authors: Bím Daniel , Svobodová Eva , Eigner Václav , Rulíšek Lubomír , Hodačová Jana 
Published: June 2016

AbstractAs part of a quest for efficient artificial catalysts of RNA phosphodiester bond cleavage, conformationally constrained mono‐ and bis‐polyazamacrocycles in which tri‐ or tetraazaalkane chains link the ortho positions of a benzene ring were synthesized. The catalytic activities of mono‐ and dinuclear copper(II) and zinc(II) complexes of these polyazamacrocycles towards cleavage of the P−O bond in 2‐hydroxypropyl‐4‐nitrophenylphosphate (HPNP) in aqueous solution at pH 7 have been determined. Only the complexes of the ligands incorporating three nitrogen atoms in a macrocycle proved to be capable of efficiently catalyzing HPNP transesterification. The dinuclear complexes were found to be approximately twice as efficient as their mononuclear counterparts, and exhibited Michaelis–Menten saturation kinetics with calculated rate constants of kcat≈10−4 s−1. By means of quantum chemical calculations (DFT/COSMO‐RS), several plausible reaction coordinates were described. By correlating the calculated barriers with the experimental kinetic data, two possible reaction scenarios were revealed, with activation free energies of 20–25 kcal mol−1.
Direct, Sequential, and Stereoselective Alkynylation of C,C‐Dibromophosphaalkenes
Authors: Shameem Muhammad A. , Esfandiarfard Keyhan , Öberg Elisabet , Ott Sascha , Orthaber Andreas 
Published: June 2016

AbstractThe first direct alkynylation of C,C‐dibromophosphaalkenes by a reaction with sulfonylacetylenes is reported. Alkynylation proceeds selectively in the trans position relative to the P substituent to afford bromoethynylphosphaalkenes. Owing to the absence of transition metals in the procedure, the previously observed conversion of dibromophosphaalkenes into phosphaalkynes through the phosphorus analog of the Fritsch–Buttenberg–Wiechell rearrangement is thus suppressed. The bromoethynylphosphaalkenes can subsequently be converted to C,C‐diacetylenic, cross‐conjugated phosphaalkenes by following a Sonogashira coupling protocol in good overall yields. By using the newly described method, full control over the stereochemistry at the P=C double bond is achieved. The substrate scope of this reaction is demonstrated for different dibromophosphaalkenes as well as different sulfonylacetylenes.
ChemInform Abstract: Structural, Magnetic, Magneto‐Caloric and Moessbauer Spectral Study of Tb2Fe17 Compound Synthesized by Arc Melting.
Authors: Charfeddine S. , Zehani K. , Bessais L. , Korchef A. 
Published: June 2016

AbstractHexagonal Tb2Fe17 is prepared by repeated arc melting of the elements without further annealing.
ChemInform Abstract: Li3Mo4P5O24: A Two‐Electron Cathode for Lithium‐Ion Batteries with Three‐Dimensional Diffusion Pathways.
Authors: Wen Bohua , Liu Jue , Chernova Natasha A. , Wang Xiaoya , Janssen Yuri , Omenya Fredrick , Khalifah Peter G. , Whittingham M. Stanley 
Published: June 2016

AbstractThe new title compound is synthesized by decomposition (350 °C, 6 h) of a gel obtained from an aqueous mixture of MoO3, NH4H2PO4, Li2CO3, and oxalic acid, followed by heating the product twice at 650 and 750 °C for 2 h.
ChemInform Abstract: All‐Metal Antiaromaticity in Sb4‐Type Lanthanocene Anions.
Authors: Min Xue , Popov Ivan A. , Pan Fu‐Xing , Li Lei‐Jiao , Matito Eduard , Sun Zhong‐Ming , Wang Lai‐Sheng , Boldyrev Alexander I. 
Published: June 2016

AbstractCompounds (IIIa—e) crystallize in the triclinic space group P$\bar 1$ with Z = 2 (single crystal XRD).
ChemInform Abstract: Highly Efficient Transition Metal Nanoparticle Catalysts in Aqueous Solutions.
Authors: Wang Changlong , Ciganda Roberto , Salmon Lionel , Gregurec Danijela , Irigoyen Joseba , Moya Sergio , Ruiz Jaime , Astruc Didier 
Published: June 2016

AbstractA tris(triazolyl)‐polyethylene glycol amphiphilic ligand is designed and successfully used as highly efficient catalyst in combination with various transition metal nanoparticles in click reactions, Suzuki—Miyaura couplings, as well as transfer hydrogenation reactions.
ChemInform Abstract: A Copper‐Based Metal—Organic Framework Acts as a Bifunctional Catalyst for the Homocoupling of Arylboronic Acids and Epoxidation of Olefins.
Authors: Parshamoni Srinivasulu , Telangae Jyothi , Sanda Suresh , Konar Sanjit 
Published: June 2016

AbstractBiaryls are prepared by the homocoupling of arylboronic acids and epoxides are obtained by epoxidation of olefins under mild conditions using a Cu2Br2‐based metal—organic framework as catalyst.
ChemInform Abstract: Visible‐Light Photoredox‐Catalyzed C—H Difluoroalkylation of Hydrazones Through an Aminyl Radical/Polar Mechanism.
Authors: Xu Pan , Wang Guoqiang , Zhu Yuchen , Li Weipeng , Cheng Yixiang , Li Shuhua , Zhu Chengjian 
Published: June 2016

AbstractA highly (E)‐stereoselective photoredox process for the direct C(sp2)—H bond difluoroalkylation of aldehyde‐derived hydrazones is reported.
ChemInform Abstract: Tris(1,2‐diphenylethylenediamine)cobalt(III) Complexes: Chiral Hydrogen Bond Donor Catalysts for Enantioselective α‐Aminations of 1,3‐Dicarbonyl Compounds.
Authors: Kumar Anil , Ghosh Subrata K. , Gladysz John A. 
Published: June 2016

AbstractThis study expands the applicability of chiral Werner complexes, based upon ethylenediamine chelates as hydrogen bond donor catalysts for the enantioselective addition of dicarbonyl compounds to di‐tert‐butyl azodicarboxylate.
ChemInform Abstract: Rhodium‐Catalyzed Bis‐Hydroaminomethylation of Linear Aliphatic Alkenes with Piperazine.
Authors: Seidensticker Thomas , Vosberg Jonas M. , Ostrowski Karoline A. , Vorholt Andreas J. 
Published: June 2016

AbstractA general protocol for bis‐hydroaminomethylation of piperazine with terminal olefins is developed.
ChemInform Abstract: Cobalt‐Catalyzed Bis‐Alkynylation of Amides via Double C—H Bond Activation.
Authors: Landge Vinod G. , Jaiswal Garima , Balaraman Ekambaram 
Published: June 2016

AbstractThe mono‐ and bis‐alkynylation of amides (I) and (IV) proceeds readily in the presence of a cobalt catalyst.
ChemInform Abstract: Pyrrole as a Directing Group: Regioselective Pd(II)‐Catalyzed Alkylation and Benzylation at the Benzene Core of 2‐Phenylpyrroles.
Authors: Wiest Johannes M. , Poethig Alexander , Bach Thorsten 
Published: June 2016

AbstractThe Pd‐catalyzed ortho‐alkylation of 2‐phenylpyrroles (I) and (IX) gives rise to 2‐substituted benzenes (III) and (XI), whilst the benzylation of substrates (XII) affords 2,6‐dibenzylbenzenes (XIII).
ChemInform Abstract: Unusual, Chemoselective Etherification of 2‐Hydroxy‐1,4‐naphthoquinone Derivatives Utilizing Alkoxymethyl Chlorides: Scope, Mechanism and Application to the Synthesis of Biologically Active Natural Product (.+‐.)‐Lantalucratin C.
Authors: Ogata Tokutaro , Yoshida Tomoyo , Shimizu Maki , Tanaka Manami , Fukuhara Chie , Ishii Junko , Nishiuchi Arisa , Inamoto Kiyofumi , Kimachi Tetsutaro 
Published: June 2016

AbstractA new method for the chemoselective etherification of 2‐hydroxy‐1,4‐naphthoquinone derivatives utilizing alkoxymethyl chlorides is studied.
ChemInform Abstract: Brook/Elimination/Aldol Reaction Sequence for the Direct One‐Pot Preparation of Difluorinated Aldols from (Trifluoromethyl)trimethylsilane and Acylsilanes.
Authors: Decostanzi Melanie , Godemert Jeremy , Oudeyer Sylvain , Levacher Vincent , Campagne Jean‐Marc , Leclerc Eric 
Published: June 2016

AbstractAn one‐pot preparation of difluorinated aldols directly from the Ruppert—Prakash reagent, acyltrimethylsilanes and aldehydes is reported.
ChemInform Abstract: Thioetherification via Photoredox/Nickel Dual Catalysis.
Authors: Jouffroy Matthieu , Kelly Christopher B. , Molander Gary A. 
Published: June 2016

AbstractThe photoredox thioetherification of (hetero)aryl bromides (II) with thiolsilicate (I) leads to a variety of (hetero)aryl propyl thioethers (III).
ChemInform Abstract: CaF2 Catalyzed Chemoselective Oxidation of Sulfides to Sulfoxides with Hydrogen Peroxide under Solvent‐Free Conditions.
Authors: Rostami Amin , Pourshiani Omid , Gheisarzade Sajede 
Published: June 2016

AbstractVarious aromatic and aliphatic sulfides are oxidized under eco‐friendly solvent‐free conditions in short reaction times.
ChemInform Abstract: Organocatalytic Enantioselective Synthesis of Tetrahydrofluoren‐9‐ones via Vinylogous Michael Addition/Henry Reaction Cascade of 1,3‐Indandione‐Derived Pronucleophiles.
Authors: Moehlmann Lennart , Chang Geng‐Hua , Madhusudhan Reddy G. , Lee Chia‐Jui , Lin Wenwei 
Published: June 2016

AbstractAn asymmetric vinylogous Michael addition/Henry cyclization cascade with 1,3‐indandione derivatives (I), (IV), and (VI) and nitro alkenes affords highly substituted tetrahydrofluorenones.
ChemInform Abstract: Synthesis of Bridged Heterocycles via Sequential 1,4‐ and 1,2‐Addition Reactions to α,β‐Unsaturated N‐Acyliminium Ions: Mechanistic and Computational Studies.
Authors: Yazici Arife , Wille Uta , Pyne Stephen G. 
Published: June 2016

AbstractSequential 1,4‐ and 1,2‐addition reactions of allylsilanes and boranes to indolizidine and quinolizidine α,β‐unsaturated N‐acyliminum ions give access to tricyclic bridged N‐heterocyclic systems.
ChemInform Abstract: Br2 as a Novel Lewis Acid Catalyst for Friedel—Crafts Alkylation of Indoles with α,β‐Unsaturated Ketones.
Authors: Liang Deqiang , Li Xiangguang , Zhang Wanshun , Li Yanni , Zhang Mi , Cheng Ping 
Published: June 2016

AbstractUnder the catalysis of 3—10 mol% of Br2, the Michael addition proceeds with high efficiency and broad substrate scope to afford the corresponding β‐indolylketone derivatives.