bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution and expression of transgene green fluorescent protein in mice survived up to four weeks following in utero gene therapys
Authors: Yang P T , Huang L , Jia W W , Skarsgard E D , Sy C 
Published: May 2017

Gene replacement offers a potential cure for degenerative disorders caused by a single gene deletion or mutation. Diagnoses of monogenic disorders in the fetus enable prenatal gene replacement which may be beneficial from the perspectives of host inflammatory/immune response, efficacy and disease prevention.
Purpose: To evaluate the distribution and expression of reporter gene green fluorescent protein (GFP) in the tissues of mice survived up to one month following in utero gene therapy.
Methods: Vesicular Stomatitis Virus-G (VSV-G) pseudotyped lentiviral (LV) vector containing GFP was prepared via triple plasmid co-transfection. Time-mated CD-1 mice underwent individual amniotic sac injection with either 1x106 LV particles or saline (controls) on gestational day 16 (term=21d), and were allowed to undergo spontaneous parturition. Pups were sacrificed on postnatal days 0, 7, 21 and 28, and neonatal and maternal tissues were analyzed for GFP transgene (by DNA polymerase chain reaction; PCR), and transgene expression by quantitative reverse transcriptase (QRT) PCR and immunohistochemistry (IHC).
Results: We observed selective transduction of neonatal tissues (trachea, lung, liver, heart, kidney, spleen, intestine, skeletal muscle), in pups undergoing in utero transfection with LV-GFP. Maternal tissues did not contain transgene despite exposure during amniotic injection. Although the numbers of pups analyzed at each postnatal time point was small, we observed variable persistence of GFP expression that appeared to be tissue specific (with persistent expression noted in intestine of 4 week old pups).
Conclusions: Neonatal tissue transfection occurs in a variety of tissues following amniotic injection with LV-GFP in this murine model of in utero gene therapy. Transgene persistence and expression patterns observed over the first 4 weeks of life may reflect tissue-specific genomic insertion of transgene that favors persistent transcription in select tissues.
CSCI-2009-2010 Call for Award Submissions
Authors: CSCI _ 
Published: May 2017

CSCI 2009-2010 AWARDS CALL FOR SUBMISSIONS
The Canadian Society for Clinical Investigation is pleased to request submissions for the following awards:

Deadline November 26, 2009:
Dr. Mel Silverman Distinguished Service Award CSCI Distinguished Scientist Award CSCI Joe Doupe Young Investigator Award

Deadline January 29, 2010:
CSCI/RCPSC Henry Friesen Award Canadian Research Awards for Specialty Residents (Medicine, Surgery)

Deadline July 5, 2010:
CSCI/CIHR Resident Research Prize

More information will follow on the CSCI website at www.csci-scrc.org
Relationship between hemoglobin and CD40 ligand in prediabetes
Authors: Kutlu Mustafa , Sonmez Alper , Genc Halil , Erdem Gokhan , Tapan Serkan , Celebi Gurkan , Haymana Cem , Taslipinar Abdullah , Uckaya Gokhan , Erbil Mehmet Kemal 
Published: May 2017

Purpose: Hemoglobin (Hb) regulates the endothelial function by modulating the bio-availability of NO at the tissue level. A significant direct relationship is present between the Hb levels and endothelial functions in patients with Type 2 diabetes. Testing whether this association also exists in subjects with prediabetes is important because prediabetes is associated with an increased risk of cardiovascular disease and mortality. Therefore, we investigated the association of Hb both with the classical cardiac risk factors and the markers for endothelial dysfunction and inflammation, in subjects with impaired glucose tolerance (IGT).

Methods: We enrolled 69 normotensive, and cardiovascular events free subjects with IGT (M=40, age=45.50±6.8 yr). Plasma insulin, hsCRP, soluble CD40L, vonWillebrand factor, p-selectin levels were measured. The parameters given according to the higher and lower median Hb values of the subjects were compared.

Results: Subjects with the higher Hb levels exhibited lower HDL-C (46.68±10.8 mg/dl vs 51.5±8.9mg/dl; P=0.04) and higher systolic (122.57±6.2mmHg vs 116.17±7.4mmHg; p < 0.001) and diastolic (79.14±3.73mmHg vs 75.58±6.1mmHg; P=0.005) blood pressures and sCD40L (7.9±3.8ng/ml vs 6.07±2.1 ng/ml; P=0.02) levels. Hb levels were correlated to the HDL cholesterol, sCD40L, systolic and diastolic blood pressures and waist circumference (r=-0.28, P=0.02; r=0.29, P=0.02; r=0.53, P < 0.001; r=0.41, P=0.001; r=0.42, P < 0.001 respectively). According to the multiple logistic regression analysis, Hb was the determinant of sCD40L levels (?=0.437, P < 0.001).

Conclusion: These results indicate that there may be a link with higher Hb values and cardiovascular risk factors in patients with IGT. Further investigation is warranted to understand the clinical implications of these findings in subjects with prediabetes.
End of Life Care in Canada: A Report from the Canadian Academy of Health Sciences Forum
Authors: Cook Deborah , Rocker Graeme 
Published: May 2017

In Ottawa on September 20, 2012, the Canadian Academy of Health Sciences held a forum entitled, ‘End of Life Care: the Last 100 Days’. Following an opening plenary by Dr. Daren Heyland, presentations and discussions ensued, highlighting recent research, current controversies, and future directions to improve end-of-life care in Canada [1]. Three articles in this issue of Clinical Investigative Medicine build on presentations from that day.
Kearifan Lokal dan Hambatan Inovasi Pertanian Suku Pedalaman Arfak di Kabupaten Manokwari Papua Barat
Authors: Mulyadi Mulyadi , Sugihen Basita G , Asngari Pang S , Susanto Djoko 
Published: May 2017

<p><em>West Papua</em><em> has the various natural resources and the human resources which have not yet been empowered optimally. Although the agriculture activities has been introduced for a long time, the subsistens agriculture has still dominated in the Arfak Tribal Group agriculture system. In their agriculture activities, the new innovation has been adopted for a short time. The new innovation on agricultural system has been considered as a disturbance of their conservative norms. But this theory disagreed by Boef et al. (1993:206) as noted that the conservative system is not the cause but the top down agriculture program which contradicted with the local wisdoms. This research is aimed to: to find the knowledge system and the local technology of Arfak people, and identify the social culture values (norms, traditional system, custom) both the supporting and the obstructing the farm of Arfak people. The results of the research showed that: (1) The Arfak tribe (people) have the indegenous knowledge to protect and to concervate the forest and to defend the food stability by the three ways, i.e (a) The three period planting, (b) multiplecrop system, (c) the natural food barn. (2) Much of the economic income has been used to fullfilled the requirements of the traditions as marrying, death, punishment of the tradition, and local fest. They are also fear to go out by the home because they believe to the supernatural power as called “Swanggi” which sent by the other village people. </em></p>
Karakteristik Pelanggan Dan Persepsi Pelanggan Terhadap Pelayanan Puskesmas (Kasus di Kota Kotamobagu dan Kabupaten Bolaang Mongondow Utara, Provinsi Sulawesi Utara)
Authors: Mokoginta Mutu G , Sugihen Basita G , Susanto Djoko , Asngari Pang S 
Published: May 2017

<p><em>Clients characteristics and clients perception to the Community health service has been considered as two important aspects. Clients characteristics measured by age, income, works, sex, education background, number of families, distances to community health service, the understanding of mean, goal, and benefit for healthy life. Clients perception to the Community health service measured by medical worker, health services and the cure that has been given has a high level category. Clients satisfaction conducted by Community Health Service tends to be high category.</em></p><p> </p><p><em><br /></em></p>
Program Pemberdayaan Small And Medium Enterprise Promotion (SMEP) Oleh Swisscontact
Authors: Jarmal Al Briham , Murdianto Murdianto 
Published: May 2017

<p>Penelitian ini bertujuan untuk menganalisis strategi pemberdayaan pada program Small and Medium Enterprise (SMEP) dan untuk menganalisis proses pemberdayaan pada program SMEP. Program ini dijalankan oleh SwissContact (salah satu NGO internasional), dan penerima manfaat adalah kelompok usaha kecil Jins di Cipulir. Metode yang digunakan pada penelitian ini adalah metode kualitatif dengan metode pengambilan sampel adalah metode snowball. Hasil dari strategi pemberdayaan yang digunakan oleh Swisscontact adalah strategi fasilitasi. Ini artinya kelompok usaha kecil Jins di Cipulir telah mengetahui permasalahan mereka namun mereka tidak mengetahui cara memecahkannya. Strategi ini menjadikan Swisscontact sebagai agen pembaharuan pada program SMEP ini. Hasil kedua dari penelitian adalah proses pemberdayaan dalam program ini dibagi atas dua tahap. Tahap pertama adalah proses primer, pada proses ini kelompok usaha kecil Jins di Cipulir diberikan sebuah pelatihan untuk mengembangkan produksinya. Kedua merupakan proses sekunder, dalam proses ini kelompok usaha kecil Jins di Cipulir memiliki sebuah kelompok diskusi dengan Swisscontact dan pemain lainnya di area tersebut. Tujuan diadakan diskusi adalah untuk mengembangkan dan memotivasi mereka selama program berlangsung.</p><p>Kata kunci: Pemberdayaan, Strategi,SMEP</p><p> </p>
Persepsi Masyarakat Sekitar Terhadap Aktivitas PT. IKPP Mills Tangerang
Authors: Rahmanita Siti Hani , Purnaningsih Ninuk 
Published: May 2017

<p>Penelitian ini adalah tentang persepsi masyarakat di sekitar PT IKPP Mills terhadap aktivitas PT. IKPP Mills Tangerang untuk kegiatan pabrik berdasarkan faktor individu dan faktor eksternal. Selain itu, penelitian ini mempelajari tentang upaya pabrik untuk mempengaruhi persepsi masyarakat sekitar pabrik yang meliputi komunikasi dan tanggung jawab sosial perusahaan (CSR). Dalam penelitian ini, identifikasi dari persepsi dilihat dari lima aspek termasuk persepsi terhadap pabrik berdasarkan bahan dasar, mesin, dan instrumen; persepsi terhadap situasi staf pabrik; persepsi terhadap proses produksi pabrik; persepsi terhadap limbah pabrik; dan persepsi terhadap pengaruh pabrik pada sosial, ekonomi, dan lingkungan. Hasil dari penelitian ini adalah sebagian besar responden memiliki persepsi positif terhadap kegiatan pabrik, kecuali terhadap limbah pabrik. Penelitian ini berguna untuk jaminan pabrik keberlanjutan dengan meningkatkan dampak positif pabrik kepada masyarakat di daerah operasi.</p><p> Kata kunci: persepsi, aspek kegiatan pabrik, upaya pabrik untuk mempengaruhi masyarakat disekitar pabrik</p><p> </p>
Effect of the batch annealing atmosphere on the oxide scale of hot-rolled AISI 430 stainless steel
Authors: Kasemkomase Nattapoj , Ouraipryvan Piya , Lothongkum Anchaleeporn Waritswat , Lothongkum Gobboon 
Published: May 2017

Abstract
The main purpose of this experiment is to study the effect of batch annealing atmospheres on oxide scales by annealing in air, hydrogen and nitrogen at 1123 K for 72, 90 and 108 ks. Grazing incidence x-ray diffraction (GIXRD) and energy dispersive X-ray (EDX) were used to characterize oxide scales after batch annealing process. The morphology and oxide scale of the studied specimens were investigated by scanning electron microscopy (SEM) and optical microscope. Result obtained by GIXRD showed Fe3O4 and spinel FeCr2O4 oxide scales on the as-received hot-rolled specimens. After batch annealing in air, Fe2O3 and (Fe,Cr)2O3 oxide scales were found. Whereas after batch annealing in hydrogen, Fe3O4 and spinel FeCr2O4 oxide scales were found. In addition, after batch annealing in nitrogen, Fe3O4, (Fe,Cr)2O3 and spinel FeCr2O4 oxide scales were seen. Oxide scales after batch annealing in air are thicker than the scales after batch annealing in hydrogen, however thinner than those scales after batch annealing in nitrogen. The oxide scales thickness after batch annealing in hydrogen is quite equivalent to that found in the as-received hot-rolled oxide scales. Cracks were observed perpendicular to the rolling direction. Weight change after batch annealing in air is higher than that after batch annealing in nitrogen and hydrogen, respectively.
Elastic properties of a swollen polyacrylamide (PAAm) gel doped with various multiwalled carbon nanotube (MWNT) contents
Authors: Evingür Gülşen Akın , Pekcan Önder 
Published: May 2017

Abstract
The toughness UT and shear modulus S of polyacrylamide (PAAm) – multiwalled carbon nanotube (MWNTs) composites were studied with various MWNT contents. These composites were prepared via free radical crosslinking copolymerization with different amounts of MWNT varying in the range between 0.1 and 50 wt.-%. The MWNT content dependency of the shear modulus of the composites due to volume phase transition was measured using tensile testing at 30 °C. It was observed that the composite preserves the ability to undergo the volume phase transition and its elastic modulus is strongly dependent on the MWNT content. The observed shear modulus first increased and then decreased above 1 wt.-% MWNT content during such loading tests. The toughness showed exactly the reverse behavior dependent on the MWNT content, as compared to the elasticity and as expected.
Mechanical testing and analysis of composite parts adhesively joined under tensile load
Authors: Sülü İsmail Yasin 
Published: May 2017

Abstract
In this paper, composite parts bonded with embedded single lap joint (SLJ) subjected to tensile load were analyzed by using 3D finite element method (FEM). In the analysis, the composite parts are carbon/epoxy (AS4/3501-6) with different fiber orientation angles and the adhesive is DP 410. The models for the numerical analyses were generated by using ANSYS software package. The finite element analyses (FEA) were carried out to predict the failure loads. Stress in x-, y- and z-directions, shear stresses and the von-Mises stresses on adhesive were obtained at the time of the failure for predetermined parameters. Consequently, the effects of orientation angles, overlap widths and length, and adhesive layer were examined. The most effective parameters were determined for composite parts adhesively bonded with embedded single lap joint.
Implications of z ∼ 6 Quasar Proximity Zones for the Epoch of Reionization and Quasar Lifetimes
Authors: Eilers Anna-Christina , Davies Frederick B. , Hennawi Joseph F. , Prochaska J. Xavier , Lukić Zarija , Mazzucchelli Chiara 
Published: May 2017

Abstract
We study quasar proximity zones in the redshift range

5.77
≤
z
≤
6.54

by homogeneously analyzing 34 medium-resolution spectra, encompassing both archival and newly obtained data, and exploiting recently updated systemic redshift and magnitude measurements. Whereas previous studies found strong evolution of proximity zone sizes with redshift and argued that this provides evidence for a rapidly evolving intergalactic medium (IGM) neutral fraction during reionization, we measure a much shallower trend

∝

(
1
+
z
)

−
1.44

. We compare our measured proximity zone sizes to predictions from hydrodynamical simulations post-processed with one-dimensional radiative transfer and find good agreement between observations and theory, irrespective of the ionization state of the ambient IGM. This insensitivity to IGM ionization state has been previously noted, and results from the fact that the definition of proximity zone size as the first drop of the smoothed quasar spectrum below the 10% flux transmission level probes locations where the ionizing radiation from the quasar is an order of magnitude larger than the expected ultraviolet ionizing background that sets the neutral fraction of the IGM. Our analysis also uncovered three objects with exceptionally small proximity zones (two have

R

p

<
1

proper Mpc), which constitute outliers from the observed distribution and are challenging to explain with our radiative transfer simulations. We consider various explanations for their origin, such as strong absorption line systems associated with the quasar or patchy reionization, but find that the most compelling scenario is that these quasars have been shining for ≲105 years.
A Multi-ringed, Modestly Inclined Protoplanetary Disk around AA Tau
Authors: Loomis Ryan A. , Öberg Karin I. , Andrews Sean M. , MacGregor Meredith A. 
Published: May 2017

Abstract
AA Tau is the archetype for a class of stars with a peculiar periodic photometric variability thought to be related to a warped inner disk structure with a nearly edge-on viewing geometry. We present high resolution (∼0.″2) ALMA observations of the 0.87 and 1.3 mm dust continuum emission from the disk around AA Tau. These data reveal an evenly spaced three-ringed emission structure, with distinct peaks at 0.″34, 0.″66, and 0.″99, all viewed at a modest inclination of 59.°1 ± 0.°3 (decidedly not edge-on). In addition to this ringed substructure, we find non-axisymmetric features, including a “bridge” of emission that connects opposite sides of the innermost ring. We speculate on the nature of this “bridge” in light of accompanying observations of HCO+ and 13CO (J = 3–2) line emission. The HCO+ emission is bright interior to the innermost dust ring, with a projected velocity field that appears rotated with respect to the resolved disk geometry, indicating the presence of a warp or inward radial flow. We suggest that the continuum bridge and HCO+ line kinematics could originate from gap-crossing accretion streams, which may be responsible for the long-duration dimming of optical light from AA Tau.
Propagation of Torsional Alfvén Waves from the Photosphere to the Corona: Reflection, Transmission, and Heating in Expanding Flux Tubes
Authors: Soler Roberto , Terradas Jaume , Oliver Ramón , Ballester José Luis 
Published: May 2017

Abstract
It has been proposed that Alfvén waves play an important role in the energy propagation through the solar atmospheric plasma and its heating. Here we theoretically investigate the propagation of torsional Alfvén waves in magnetic flux tubes expanding from the photosphere up to the low corona and explore the reflection, transmission, and dissipation of wave energy. We use a realistic variation of the plasma properties and the magnetic field strength with height. Dissipation by ion–neutral collisions in the chromosphere is included using a multifluid partially ionized plasma model. Considering the stationary state, we assume that the waves are driven below the photosphere and propagate to the corona, while they are partially reflected and damped in the chromosphere and transition region. The results reveal the existence of three different propagation regimes depending on the wave frequency: low frequencies are reflected back to the photosphere, intermediate frequencies are transmitted to the corona, and high frequencies are completely damped in the chromosphere. The frequency of maximum transmissivity depends on the magnetic field expansion rate and the atmospheric model, but is typically in the range of 0.04–0.3 Hz. Magnetic field expansion favors the transmission of waves to the corona and lowers the reflectivity of the chromosphere and transition region compared to the case with a straight field. As a consequence, the chromospheric heating due to ion–neutral dissipation systematically decreases when the expansion rate of the magnetic flux tube increases.
How Are Obesity and Body Composition Related to Patellar Cartilage? A Systematic Review
Authors: Hussain Sultana Monira , Tan Mae Chyi , Stathakopoulos Krista , Cicuttini Flavia M. , Wang Yuanyuan , Chou Louisa , Urquhart Donna M. , Wluka Anita E. 
Published: May 2017

Objective.The aim of this review was to systematically examine the evidence for an association between measures of obesity [weight and body mass index (BMI)] and body composition (fat mass and fat-free mass) and patellar cartilage, assessed using magnetic resonance imaging.Methods.Three electronic databases (MEDLINE, EMBASE, and CINAHL) were searched up to April 2016 using full text and MeSH terms to identify studies examining the associations between obesity and body composition, and patellar cartilage. Two independent reviewers extracted the data and assessed the methodological quality of included studies.Results.Seventeen studies were included: 5 cross-sectional, 10 cohort studies measuring outcomes at 2 timepoints, and 2 longitudinal studies assessing outcome only at the timepoint. Eleven studies were of high or moderate quality. In asymptomatic middle-aged adults, elevated body weight and BMI were systematically associated with worse patellofemoral cartilage scores. There was more consistent evidence for patellar cartilage defects than patellar cartilage volume, particularly in women. Increased BMI was also consistently associated with increased cartilage loss in longitudinal studies, although not all attained statistical significance.Conclusion.There is a need for more high-quality research to confirm these findings and to better explain the relative contributions of metabolic and biomechanical factors to the initiation of patellofemoral osteoarthritis, to devise effective strategies to manage this common and disabling condition.
Initial development of cowpea plants under salt stress and phosphate fertilization
Authors: Silva Sá Francisco Vanies da , Neto Miguel Ferreira , De Lima Yuri Bezerra , De Paiva Emanoela Pereira , Gheyi Hans Raj , Dias Nildo Da Silva 
Published: May 2017

The objective of this work was to study the effects of irrigation with saline water associated with phosphate fertilization on the emergence and early growth of cowpea plants. The assay was conducted in the greenhouse of the Department of Environmental Sciences and Technology of the Federal Rural University of the Semi-Arid (UFERSA) in Mossoró-RN, during October and November of 2015. The study adopted a randomized block with treatments arranged in a 5 x 3 grid, corresponding to five levels of water salinity (0.5, 1.5, 2.5, 3.5 and 4.5 dS m-1) and three doses of superphosphate, based upon the soil analysis (60%, 100% and 140% of the recommended dose for the crop 60 kg P2O5 ha-1), with five repetitions. The cowpea plants, cv. Paulistinha, were grown in lysimeters with capacity of 8 dm3. During the first 15 days of the initial stage of development the plants were evaluated for emergence, growth and biomass accumulation. The increase in water salinity above 1.5 dSm-1 reduced the emergence, growth and dry matter accumulation of cowpea plants. The increase of 40% in the recommendation of phosphorus fertilization of cowpea increased the growth and biomass accumulation of shoot plants, regardless of salinity.
Nonlinear Dynamical Behaviour in a Predator-Prey Model with Harvesting
Authors: Liu Wei , Jiang Yaolin 
Published: May 2017

AbstractWe investigate the stability and periodic orbits of a predator-prey model with harvesting. The model has a biologically-meaningful interior, an attractor undergoing damped oscillations, and can become destabilised to produce periodic orbits via a Hopf bifurcation. Some sufficient conditions for the existence of the Hopf bifurcation are established, and a stability analysis for the periodic solutions using a Lyapunov function is presented. Finally, some computer simulations illustrate our theoretical results.
Uncertainty Quantification of Derivative Instruments
Authors: Sun Xianming , Vanmaele Michèle 
Published: May 2017

AbstractModel and parameter uncertainties are common whenever some parametric model is selected to value a derivative instrument. Combining the Monte Carlo method with the Smolyak interpolation algorithm, we propose an accurate efficient numerical procedure to quantify the uncertainty embedded in complex derivatives. Except for the value function being sufficiently smooth with respect to the model parameters, there are no requirements on the payoff or candidate models. Numerical tests carried out quantify the uncertainty of Bermudan put options and down-and-out put options under the Heston model, with each model parameter specified in an interval.