bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors predicting the self‐evaluated health of hidradenitis suppurativa patients recruited from an outpatient clinic
Authors: Kjærsgaard Andersen R. , Theut Riis P. , Jemec G.B.E. 
Published: August 2017

AbstractObjectivesIn recent years, Hidradenitis suppurativa has received increased attention but still lack well‐defined, robust patient‐reported outcome measures. Such measures are likely to be influenced by contextual factors. We, therefore, aim to describe the association of biological and other factors with HS patient's self‐evaluated health as reflected by the EQ5D VAS score.MethodsThis cross‐sectional study measured basic information, Dermatology Life Quality Index, Major Depression Inventory and Euro‐QoL‐5D. Information obtained through questionnaires was used to create a model showing the relation between biological factors, questionnaire results and self‐evaluated health using the stepwise method for linear regression. Patients with HS (n = 805) registered at our department were invited to participate. A total of 503 (62.5%) patients replied to this survey. There was no difference in basic demographics between responders and non‐responders.ResultsPossible predictors for this study were DLQI, MDI, BMI, smoking, gender. A final model for correlation with self‐evaluated health was obtained. Significant predictors for the model were DLQI (P < 0.05), BMI points above 25 and active smoking (both: P < 0.01) and MDI (P < 0.001).ConclusionAs this is a cross‐sectional study, it reveals several clinically relevant correlations. Smoking appears to correlate with the highest change in VAS score, but an MDI of 10 (lower than study average) or a BMI of 40 influences the results more. This study provides an assessment of how much BMI and smoking, in relation to other factors, correlate to the self‐evaluated health state of patients with HS. These may, therefore, be relevant contextual factors to the construction and interpretation of specific patient‐reported outcome measures. To improve QoL, we advocate smoking cessation and weight loss, and advice active screening for depression as over 10% of our patients qualify for a depressive diagnosis according to ICD‐10.
Fragrance contact allergens in 5588 cosmetic products identified through a novel smartphone application
Authors: Bennike N.H. , Oturai N.B. , Müller S. , Kirkeby C.S. , Jørgensen C. , Christensen A.B. , Zachariae C. , Johansen J.D. 
Published: August 2017

AbstractBackgroundMore than 25% of the adult European population suffers from contact allergy, with fragrance substances recognized as one of the main causes. Since 2005, 26 fragrance contact allergens have been mandatory to label in cosmetic products within the EU if present at 10 ppm or above in leave‐on and 100 ppm or above in wash‐off cosmetics.ObjectiveTo examine exposure, based on ingredient labelling, to the 26 fragrances in a sample of 5588 fragranced cosmetic products.MethodsThe investigated products were identified through a novel, non‐profit smartphone application (app), designed to provide information to consumers about chemical substances in cosmetic products. Products registered through the app between December 2015 and October 2016 were label checked according to International Nomenclature of Cosmetic Ingredients (INCI) for the presence of the 26 fragrance substances or the wording ‘fragrance/parfum/aroma’.ResultsThe largest product categories investigated were ‘cream, lotion and oil’ (n = 1192), ‘shampoo and conditioner’ (n = 968) and ‘deodorants’ (n = 632). Among cosmetic products labelled to contain at least one of the 26 fragrances, 85.5% and 73.9% contained at least two and at least three of the 26 fragrances, respectively. Linalool (49.5%) and limonene (48.5%) were labelled most often among all investigated products. Hydroxyisohexyl 3‐cyclohexene carboxaldehyde (HICC/Lyral®) was found in 13.5% of deodorants. Six of the 26 fragrance substances were labelled on less than one per cent of all products, including the natural extracts Evernia furfuracea (tree moss) and Evernia prunastri (oak moss). A total of 329 (5.9%) products had one or more of the 26 fragrance substances labelled but did not have ‘parfum/fragrance/aroma’ listed on the label.ConclusionsConsumers are widely exposed to, often multiple, well‐established fragrance contact allergens through various cosmetic products intended for daily use. Several fragrance substances that are common causes of contact allergy were rarely labelled in this large sample of cosmetic products.
Patients with psoriasis have different preferences for topical therapy, highlighting the importance of individualized treatment approaches: randomized phase IIIb PSO‐INSIGHTFUL study
Authors: Hong C‐H. , Papp K.A. , Lophaven K.W. , Skallerup P. , Philipp S. 
Published: August 2017

AbstractBackgroundPoor adherence to topical therapy in psoriasis remains an issue; it is associated with poor clinical outcomes, reduced quality of life and increased costs. Treatment‐related factors leading to poor adherence include lack of efficacy, excessive time applying medication and poor cosmetic characteristics (e.g. slow absorption, greasiness).ObjectiveTo assess the topical treatment attributes that influence patient preference for fixed combination calcipotriol 50 μg/g (Cal) and betamethasone 0.5 mg/g as dipropionate (BD) foam vs. gel, as well as in comparison with the latest topical treatment (LTT) a patient received.MethodsPSO‐INSIGHTFUL was a Phase IIIb, prospective, multicentre (Canada/Germany), open‐label, randomized, two‐arm crossover study in patients aged ≥18 years with mild‐to‐severe psoriasis (NCT02310646). Following a washout period of up to 4 weeks, patients were randomized 1 : 1 to once‐daily Cal/BD foam for 1 week, followed by Cal/BD gel for 1 week, or vice versa. Patients completed six questionnaires evaluating patient preferences.ResultsA total of 213 patients were randomized; 118 had received a topical treatment in the previous 3 months. Based on the Subject's Preference Assessment, 50% of patients preferred Cal/BD foam and 50% preferred Cal/BD gel. Based on the Topical Product Usability Questionnaire (TPUQ), overall mean scores were high for both Cal/BD foam and gel, and were often significantly in favour of both products compared with LTT. Greater differences between Cal/BD foam and gel vs. LTT occurred when the previous treatment was an ointment or cream. Cal/BD foam was generally preferred by younger patients (aged 18–39 years), whereas Cal/BD gel tended to be preferred by older patients (aged ≥40 years). Results from other questionnaires were aligned with the TPUQ.ConclusionsPatients with psoriasis have diverse needs and different preferences for topical treatment. This knowledge may help prescribers to choose the right formulation for the right patient, potentially leading to improved adherence and better treatment outcomes.
Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism
Authors: Durham Benjamin S. , Grigg Ronald , Wood Ian C. 
Published: August 2017

AbstractHistone deacetylase (HDAC) inhibitors prevent neural cell death in in vivo models of cerebral ischaemia, brain injury and neurodegenerative disease. One mechanism by which HDAC inhibitors may do this is by suppressing the excessive inflammatory response of chronically activated microglia. However, the molecular mechanisms underlying this anti‐inflammatory effect and the specific HDAC responsible are not fully understood. Recent data from in vivo rodent studies have shown that inhibition of class I HDACs suppresses neuroinflammation and is neuroprotective. In our study, we have identified that selective HDAC inhibition with inhibitors apicidin, MS‐275 or MI‐192, or specific knockdown of HDAC1 or 2 using siRNA, suppresses the expression of cytokines interleukin‐6 (IL‐6) and tumour necrosis factor‐alpha (TNF‐α) in BV‐2 murine microglia activated with lipopolysaccharide (LPS). Furthermore, we found that in the absence of HDAC1, HDAC2 is up‐regulated and these increased levels are compensatory, suggesting that these two HDACs have redundancy in regulating the inflammatory response of microglia. Investigating the possible underlying anti‐inflammatory mechanisms suggests an increase in protein expression is not important. Taken together, this study supports the idea that inhibitors selective towards HDAC1 or HDAC2, may be therapeutically useful for targeting neuroinflammation in brain injuries and neurodegenerative disease.
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Perceptions of caregivers and providers regarding the potential introduction of the varicella vaccine to the childhood immunisation schedule in New Zealand: A qualitative exploratory study
Authors: Charania Nadia A , Watson Donna G , Turner Nikki M 
Published: August 2017

AimThe varicella vaccine has been proposed to be added to the childhood immunisation schedule in New Zealand as the fourth injectable at the 15‐month event. We sought to understand the perceptions of caregivers and health‐care providers regarding the potential introduction of routine varicella vaccination.MethodsA qualitative exploratory study was conducted using semi‐structured interviews with caregivers and providers (N = 20) in Auckland. Key themes from the interviews were identified through thematic analysis using a combination of deductive and inductive coding.ResultsAll of the participants were aware of varicella but levels of awareness varied among caregivers regarding the varicella vaccine. Participants expressed positive support towards universal varicella vaccination and a high intention to vaccinate if available as a routine vaccine. However, many concerns were raised about multiple injections at a single immunisation visit, and participants suggested alternative scheduling options.ConclusionThe results indicated a need to raise awareness among caregivers about the varicella vaccine, focusing on positive health beliefs about vaccination in terms of protecting the child's health and reducing the impact of a child getting varicella on the family. Health‐care providers and government health authorities may play an important role in increasing positive health beliefs about the varicella vaccine. Should the varicella vaccine be introduced as proposed, our findings recommend an educational campaign to address both caregiver and provider concerns about multiple injections and how to manage alternative immunisation schedules. These insights may help inform national strategies for the proposed addition to increase acceptance of the varicella vaccination.
Structural uplift and ejecta thickness of lunar mare craters: New insights into the formation of complex crater rims
Authors: Krüger Tim , Kenkmann Thomas , Hergarten Stefan 
Published: August 2017

AbstractWe investigate the elevated crater rims of lunar craters. The two main contributors to this elevation are a structural uplift of the preimpact bedrock and the emplacement of ejecta on top of the crater rim. Here, we focus on five lunar complex mare craters with diameters ranging between 16 and 45 km: Bessel, Euler, Kepler, Harpalus, and Bürg. We performed 5281 measurements to calculate precise values for the structural rim uplift and the ejecta thickness at the elevated crater rim. The average structural rim uplift for these five craters amounts to SRU = 70.6 ± 1.8%, whereas the ejecta thickness amounts to ET = 29.4 ± 1.8% of the total crater rim elevation. Erosion is capable of modifying the ratio of ejecta thickness to structural rim uplift. However, to minimize the impact of erosion, the five investigated craters are young, pristine craters with mostly preserved ejecta blankets. To quantify how strongly craters were enlarged by crater modification processes, we reconstructed the dimensions of the transient crater. The difference between the transient crater diameter and the final crater diameter can extend up to 11 km. We propose reverse faulting and thrusting at the final crater rim to be one of the main contributing factors of forming the elevated crater rim.
Baby‐Friendly Hospital designation has a sustained impact on continued breastfeeding
Authors: Spaeth Anna , Zemp Elisabeth , Merten Sonja , Dratva Julia 
Published: August 2017

AbstractThe Baby‐Friendly Hospital (BFH) Initiative has led to an increase in breastfeeding rates and duration worldwide. But little is known about whether the beneficial effects persist beyond a facility's designation as a BFH. To investigate the association of BFH designation (current, former, and never) and compliance with Baby‐Friendly (BF) practices on breastfeeding in Switzerland, this study combined nationwide survey data on breastfeeding with BFH monitoring data. In this cross‐sectional study, 1,326 children were born in 34 current (N = 508), 28 former (N = 425), and 34 never designated BFHs (N = 393). We compared exclusive and any breastfeeding according to BFH designation over the first year of life, using Kaplan‐Meyer Survival curves. Logistic regression models were applied to analyse breastfeeding prevalence, and Cox‐regression models were used for exclusive (0–6 months) and continued (6–12 months) breastfeeding duration. Average duration of exclusive breastfeeding (13.1 weeks, 95% confidence interval [12.0, 17.4]) and any breastfeeding (32.7 weeks, 95% confidence interval [30.5, 39.2]) were the longest for babies born in currently accredited BFHs. Exclusive breastfeeding was associated with high compliance with monitored BF practices in current BFHs and with the number of BF practices experienced in all hospitals. Continued breastfeeding was significantly longer when babies were born in current BFHs (cessation hazard ratio 0.60, 95% confidence interval [0.42, 0.84]) or in former BFHs (cessation hazard ratio 0.68, 95% confidence interval [0.48, 0.97]). Overall, the results support continued investment into BFHs, because babies born in current BFHs are breastfed the most and the longest, whereas a former BFH designation shows a sustained effect on continued breastfeeding.
Schoenberg and Liszt: Hexatonic Collections across the Great Tonal Divide
Authors: ARGENTINO JOE 
Published: August 2017

ABSTRACTThis article explores passages from Liszt's and Schoenberg's compositions that share the versatile hexatonic collection which can function within, without or somewhere in between a tonal harmonic framework. The underlying harmonic structure of the hexatonic‐based passages from Liszt's oratorioSt. Stanislaus(1875), Schoenberg's ‘Nacht’ fromPierrot lunaire(1912), andModern Psalm, Op. 50c (1950), are almost identical, even though the works were written in distinctly different genres and at very different times. The extramusical associations in these works, in which the sublime or supernatural is represented by hexatonic‐based symmetry, recurs in the compositions examined here.
The potential of the spectral ‘water balance index’ (WABI) for crop irrigation scheduling
Authors: Rapaport Tal , Hochberg Uri , Cochavi Amnon , Karnieli Arnon , Rachmilevitch Shimon 
Published: August 2017

Summary

Hyperspectral sensing can detect slight changes in plant physiology, and may offer a faster and nondestructive alternative for water status monitoring. This premise was tested in the current study using a narrow‐band ‘water balance index’ (WABI), which is based on independent changes in leaf water content (1500 nm) and the efficiency of the nonphotochemical quenching (NPQ) photo‐protective mechanism (531 nm).

The hydraulic, photo‐protective and spectral behaviors of five important crops – grapevine, corn, tomato, pea and sunflower – were evaluated under water deficit conditions in order to associate the differences in stress physiology with WABI suitability.

Rapid alterations in both leaf water content and NPQ were observed in grapevine, pea and sunflower, and were effectively captured by WABI. Apart from water status monitoring, the index was also successful in scheduling the irrigation of a vineyard, despite phenological and environmental variability. Conversely, corn and tomato displayed a relatively strict stomatal regime and/or mild NPQ responses and were, thus, unsuitable for WABI‐based monitoring.

WABI shows great potential for irrigation scheduling of various crops, and has a clear advantage over spectral models that focus on either of the abovementioned physiological mechanisms.
A limited evaluation of the association of race and anesthetic medication administration: A single‐center experience with appendectomies
Authors: Rosenbloom Julia M. , Senthil Kumaran , Long Alexander S. , Robinson Whitney R. , Peeples Kenneth N. , Fiadjoe John E. , Litman Ronald S. 
Published: August 2017

SummaryBackgroundAlthough it is known that a patient's race may influence their medical care, racial patterns of medication administration in pediatric anesthesia have not been well‐studied. The aim of this study was to determine if differences exist between Black and White children with regard to administration of anesthetic and analgesic medications for a single procedure at our institution.MethodsWe conducted a retrospective review of medications administered to patients for emergency appendectomies at a large academic children's hospital from 2010 to 2015. We examined the association between patient race and administration of preoperative midazolam and intraoperative ondansetron, lidocaine, ketorolac, and weight‐based doses of fentanyl and morphine.ResultsDuring the study period, 1680 patients (1329 White, 351 Black) underwent emergency appendectomy. There were no significant racial differences in administration of intraoperative anesthetic medications between Black and White children. In unadjusted analysis, Black children were less likely to receive preoperative midazolam than White children (OR=0.74 [95% CI, 0.58‐0.94], P=.012). After adjusting for confounders, there was no evidence of racial differences in administration of preoperative or intraoperative medications.ConclusionWe did not find a significant difference in preoperative or intraoperative medication administration based on race when we adjusted for age, gender, and attending anesthesiologist practice patterns. We encourage all institutions to monitor their own practice patterns with regard to race.
Transfer of tomato immune receptor Ve1 confers Ave1‐dependent Verticillium resistance in tobacco and cotton
Authors: Song Yin , Liu Linlin , Wang Yidong , Valkenburg Dirk‐Jan , Zhang Xianlong , Zhu Longfu , Thomma Bart P. H. J. 
Published: August 2017

SummaryVerticillium wilts caused by soilborne fungal species of the Verticillium genus are economically important plant diseases that affect a wide range of host plants and are notoriously difficult to combat. Perception of pathogen(‐induced) ligands by plant immune receptors is a key component of plant innate immunity. In tomato, race‐specific resistance to Verticillium wilt is governed by the cell surface‐localized immune receptor Ve1 through recognition of the effector protein Ave1 that is secreted by race 1 strains of Verticillium spp. It was previously demonstrated that transgenic expression of tomato Ve1 in the model plant Arabidopsis thaliana leads to Verticillium wilt resistance. Here, we investigated whether tomato Ve1 can confer Verticillium resistance when expressed in the crop species tobacco (Nicotiana tabcum) and cotton (Gossypium hirsutum). We show that transgenic tobacco and cotton plants constitutively expressing tomato Ve1 exhibit enhanced resistance against Verticillium wilt in an Ave1‐dependent manner. Thus, we demonstrate that the functionality of tomato Ve1 in Verticillium wilt resistance through recognition of the Verticillium effector Ave1 is retained after transfer to tobacco and cotton, implying that the Ve1‐mediated immune signalling pathway is evolutionary conserved across these plant species. Moreover, our results suggest that transfer of tomato Ve1 across sexually incompatible plant species can be exploited in breeding programmes to engineer Verticillium wilt resistance.
A selective insecticidal protein from Pseudomonas mosselii for corn rootworm control
Authors: Wei Jun‐Zhi , O'Rear Jessica , Schellenberger Ute , Rosen Barbara A. , Park Young‐Jun , McDonald Mark J. , Zhu Genhai , Xie Weiping , Kassa Adane , Procyk Lisa , Perez Ortega Claudia , Zhao Jian‐Zhou , Yalpani Nasser , Crane Virginia C. , Diehn Scott H. , Sandahl Gary A. , Nelson Mark E. , Lu Albert L. , Wu Gusui , Liu Lu 
Published: August 2017

SummaryThe coleopteran insect western corn rootworm (WCR, Diabrotica virgifera virgifera) is an economically important pest in North America and Europe. Transgenic corn plants producing Bacillus thuringiensis (Bt) insecticidal proteins have been useful against this devastating pest, but evolution of resistance has reduced their efficacy. Here, we report the discovery of a novel insecticidal protein, PIP‐47Aa, from an isolate of Pseudomonas mosselii. PIP‐47Aa sequence shows no shared motifs, domains or signatures with other known proteins. Recombinant PIP‐47Aa kills WCR, two other corn rootworm pests (Diabrotica barberi and Diabrotica undecimpunctata howardi) and two other beetle species (Diabrotica speciosa and Phyllotreta cruciferae), but it was not toxic to the spotted lady beetle (Coleomegilla maculata) or seven species of Lepidoptera and Hemiptera. Transgenic corn plants expressing PIP‐47Aa show significant protection from root damage by WCR. PIP‐47Aa kills a WCR strain resistant to mCry3A and does not share rootworm midgut binding sites with mCry3A or AfIP‐1A/1B from Alcaligenes that acts like Cry34Ab1/Cry35Ab1. Our results indicate that PIP‐47Aa is a novel insecticidal protein for controlling the corn rootworm pests.
Single‐base methylome analysis reveals dynamic epigenomic differences associated with water deficit in apple
Authors: Xu Jidi , Zhou Shasha , Gong Xiaoqing , Song Yi , van Nocker Steve , Ma Fengwang , Guan Qingmei 
Published: August 2017

SummaryCytosine methylation is an essential feature of epigenetic regulation and is involved in various biological processes. Although cytosine methylation has been analysed at the genomic scale for several plant species, there is a general lack of understanding of the dynamics of global and genic DNA methylation in plants growing in environments challenged with biotic and abiotic stresses. In this study, we mapped cytosine methylation at single‐base resolution in the genome of commercial apple (Malus x domestica), and analysed changes in methylation patterns associated with water deficit in representative drought‐sensitive and drought‐tolerant cultivars. We found that the apple genome exhibits ~54%, ~38% and ~8.5% methylation at CG, CHG and CHH sequence contexts, respectively. We additionally documented changes in gene expression associated with water deficit in an attempt to link methylation and gene expression changes. Global methylation and transcription analysis revealed that promoter‐unmethylated genes showed higher expression levels than promoter‐methylated genes. Gene body methylation appears to be positively correlated with gene expression. Water deficit stress was associated with changes in methylation at a multitude of genes, including those encoding transcription factors (TFs) and transposable elements (TEs). These results present a methylome map of the apple genome and reveal widespread DNA methylation alterations in response to water deficit stress. These data will be helpful for understanding potential linkages between DNA methylation and gene expression in plants growing in natural environments and challenged with abiotic and biotic stresses.