bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 12‐year retrospective analysis of non‐operative management for paediatric duodenal hematomas caused by trauma at a single center
Authors: Shen Qiulong , Li Yi , Wang Dayong , Wang Li , Li Shuanling , Chen Long , Liu Tingting 
Published: September 2024

AbstractBackgroundPaediatric traumatic duodenal hematoma is a rare type of blunt abdominal injury for which treatment strategies are controversial. This study aimed to evaluate the application value of nonoperative management of paediatric duodenal hematoma caused by trauma.MethodsA retrospective analysis was conducted on patients with duodenal hematoma with a confirmed history of abdominal trauma admitted to our hospital between January 2010 and December 2022. General patient information, including age, sex, cause of injury, clinical manifestations, and treatment outcomes, was recorded.ResultsA total of 11 cases were included in this study, with 6 males and 5 females. School‐age children (≥6 years) accounted for 72.7% (8/11) of the cases. Bicycle handlebar injuries accounted for 63.6% (7/11) of cases. Among these cases, 5 (45.5%) were classified as American Association for the Surgery of Trauma grade I, while the remaining were classified as grade II. The median history time was 1 day (range: 2 h–12 days). All patients were successfully treated using non‐operative methods. The median time to oral feeding after injury was 17 days (range: 9–32 days). Oral feeding was initiated within 2 weeks in 2 patients (18.2%), within 3 weeks in 6 patients (54.5%), and within 4 weeks in 10 patients (90.9%).ConclusionPaediatric traumatic duodenal hematoma is more common in school‐aged children, mainly due to bicycle handlebar injuries. Nonoperative treatment is proven to be safe and effective, with duodenal obstruction symptoms typically resolving within 4 weeks.
Editorial: Advancing care in Crohn's disease—Time to standardise bowel preparation scales
Authors: Shehab Mohammad , Bessissow Talat 
Published: September 2024

LINKED CONTENTThis article is linked to Solitano et al papers. To view these articles, visit https://doi.org/10.1111/apt.18210 and https://doi.org/10.1111/apt.18288
Comparing regulatory guidance on risk minimization/mitigation and the Reporting recommendation Intended for pharmaceutical Risk Minimization Evaluation Studies checklist
Authors: Guleria Sonia , Brouwer Emily , Brown David A. , Hakkarainen Katja M. 
Published: September 2024

AbstractThe latest country‐specific regulatory guidance for assessing effectiveness of risk minimization measures (RMM) strategies was identified across five continents—Africa (Egypt, South Africa), Asia (Australia, China, Japan, South Korea, Singapore), Europe (EU‐27, United Kingdom), North America (Unites States, Canada) and South America (Brazil)—and compared to the Reporting recommendation Intended for pharmaceutical Risk Minimization Evaluation Studies (RIMES) checklist, developed to assess the quality of effectiveness evaluations and endorsed by the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP). RIMES checklist items address study hypothesis, participants, measures, statistical analysis and results. European Medical Agency (EMA) and Food and Drug Administration (FDA) guidance only partially aligned with RIMES, primarily for measures and results. In the absence of country‐specific guidance, most countries recommended following EMA or FDA guidelines; Japan and South Africa mentioned the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH E2E) guideline; Brazil and China had no guidance/recommendations. Worldwide, there was a lack of RMM‐specific guidance and, when guidance existed, they were not harmonized, and alignment with the RIMES checklist was limited.
Pathogenic G6PD variants: Different clinical pictures arise from different missense mutations in the same codon
Authors: Costa Simonetta , Minucci Angelo , Kumawat Amit , De Bonis Maria , Prontera Giorgia , Gelsomino Mariannita , Tana Milena , Tiberi Eloisa , Romano Alberto , Ruggiero Antonio , Mastrangelo Stefano , Palumbo Giuseppe , Giorgio Valentina , Onori Maria Elisabetta , Bolognesi Martino , Camilloni Carlo , Luzzatto Lucio , Vento Giovanni 
Published: September 2024

SummaryG6PD deficiency results from mutations in the X‐linked G6PD gene. More than 200 variants are associated with enzyme deficiency: each one of them may either cause predisposition to haemolytic anaemia triggered by exogenous agents (class B variants), or may cause a chronic haemolytic disorder (class A variants). Genotype–phenotype correlations are subtle. We report a rare G6PD variant, discovered in a baby presenting with severe jaundice and haemolytic anaemia since birth: the mutation of this class A variant was found to be p.(Arg454Pro). Two variants affecting the same codon were already known: G6PD Union, p.(Arg454Cys), and G6PD Andalus, p.(Arg454His). Both these class B variants and our class A variant exhibit severe G6PD deficiency. By molecular dynamics simulations, we performed a comparative analysis of the three mutants and of the wild‐type G6PD. We found that the tetrameric structure of the enzyme is not perturbed in any of the variants; instead, loss of the positively charged Arg residue causes marked variant‐specific rearrangement of hydrogen bonds, and it influences interactions with the substrates G6P and NADP. These findings explain severe deficiency of enzyme activity and may account for p.(Arg454Pro) expressing a more severe clinical phenotype.
A prediction model of dementia conversion for mild cognitive impairment by combining plasma pTau181 and structural imaging features
Authors: Li Tao‐Ran , Li Bai‐Le , Zhong Jin , Xu Xin‐Ran , Wang Tai‐Shan , Liu Feng‐Qi ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2024

AbstractAimsThe early stages of Alzheimer's disease (AD) are no longer insurmountable. Therefore, identifying at‐risk individuals is of great importance for precise treatment. We developed a model to predict cognitive deterioration in patients with mild cognitive impairment (MCI).MethodsBased on the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, we constructed models in a derivation cohort of 761 participants with MCI (138 of whom developed dementia at the 36th month) and verified them in a validation cohort of 353 cognitively normal controls (54 developed MCI and 19 developed dementia at the 36th month). In addition, 1303 participants with available AD cerebrospinal fluid core biomarkers were selected to clarify the ability of the model to predict AD core features. We assessed 32 parameters as candidate predictors, including clinical information, blood biomarkers, and structural imaging features, and used multivariable logistic regression analysis to develop our prediction model.ResultsSix independent variables of MCI deterioration were identified: apolipoprotein E ε4 allele status, lower Mini‐Mental State Examination scores, higher levels of plasma pTau181, smaller volumes of the left hippocampus and right amygdala, and a thinner right inferior temporal cortex. We established an easy‐to‐use risk heat map and risk score based on these risk factors. The area under the curve (AUC) for both internal and external validations was close to 0.850. Furthermore, the AUC was above 0.800 in identifying participants with high brain amyloid‐β loads. Calibration plots demonstrated good agreement between the predicted probability and actual observations in the internal and external validations.ConclusionWe developed and validated an accurate prediction model for dementia conversion in patients with MCI. Simultaneously, the model predicts AD‐specific pathological changes. We hope that this model will contribute to more precise clinical treatment and better healthcare resource allocation.
Understanding the diversity of private conservation in the Peruvian Amazon
Authors: Lagneaux Elisabeth G. , Quaedvlieg Julia , Sabogal David , Jansen Merel 
Published: September 2024

AbstractGlobal awareness about the threats of ecosystem degradation in the Amazon is growing. While state‐managed protected areas remain key instruments for forest conservation, private actors are increasingly funding and implementing a broad range of conservation initiatives. Private actors are transforming the Amazonian conservation landscape and its governance, however, many aspects of private conservation, especially the diversity of local practitioners and the challenges they face, remain understudied. Drawing on a case study of Madre de Dios in the Peruvian Amazon, we aim to generate a better understanding of private conservation practitioners and their various approaches to conservation on private and public land. We used an extensive review of literature and databases, in addition to 13 semi‐structured interviews with various private conservation practitioners, to map privately conserved areas, and to gather perceptions about challenges, opportunities, and future pathways for private conservation. A total of 590 privately conserved areas, covering over one million hectares, were identified and mapped in Madre de Dios. We find that, while most initiatives are managed by individuals and families, for‐profit companies manage half of the total area privately protected. Furthermore, we find that private conservation initiatives face significant barriers and pressures. These barriers include complex bureaucratic processes, legal contradictions and incoherencies, corruption, weak law enforcement, and financial insecurity. Conservation policies largely favor national and international actors and less so local, grassroots initiatives run by individuals and communities. Finally, we highlight the need for more accessible and inclusive policies that recognize the contribution of less powerful actors, to foster more effective conservation efforts for the future of the Amazon.
Challenges to Empowerment of Women through Value Chains: The Need to Move from Individual to Relational Empowerment
Authors: Nguyen Phuong , Scheyvens Regina , Beban Alice , Gardyne Samantha 
Published: September 2024

ABSTRACTThis article examines the prevailing assumption by donors that connecting smallholder women to value chains will close the gender gap and empower women. Based on a case study of a programme that seeks to empower women through their integration into value chains in Vietnam, the article assesses women's empowerment across four dimensions: economic, psychological, social and political. The authors argue that women's engagement in value chains does not always financially benefit and empower women because patriarchal power structures within families, communities and businesses make it challenging for women to gain authority over production decisions in higher‐value crops. Women in the study gained more autonomy over ‘women's crops’ which yielded small incomes, while men had control over production that was seen as ‘men's work’, and in large‐scale and more lucrative production. Gendered power relations affect women's access to economic opportunities: in this context, development agencies should reconsider their approaches to women's economic empowerment by focusing on relational rather than individual empowerment. This means that women's economic empowerment programmes should involve both men and women, with targeted interventions ensuring women are empowered within the household and in their connections with the community, local authorities and businesses.
Clinical and laboratory characteristics during a 1‐year follow‐up in European Lyme neuroborreliosis: A prospective cohort study
Authors: Solheim Anne Marit , Skarstein Ingerid , Quarsten Hanne , Lorentzen Åslaug Rudjord , Berg‐Hansen Pål , Eikeland Randi , Reiso Harald , Mygland Åse , Ljøstad Unn 
Published: September 2024

AbstractBackground and PurposeWe need more knowledge on clinical presentations, time course, biomarkers, and prognosis in European Lyme neuroborreliosis (LNB).MethodsA prospective 12‐month follow‐up of predetermined clinical and laboratory parameters was undertaken in 105 patients with LNB.ResultsAt presentation, 79% had radiculopathy, 49% had facial palsy, and 13% had solely subjective symptoms (predominately pain). Intrathecally produced Borrelia burgdorferi (Bb) antibodies were demonstrated and cerebrospinal fluid (CSF) CXCL13 was positive in 85% and 82% pretreatment, in 73% and 10% at 6 months, and in 58% and 14% at 12 months, respectively. CSF Bb polymerase chain reaction (PCR) was positive in 40% pretreatment. In four patients who tested negative for Bb antibodies in both serum and CSF, the diagnosis was supported by typical clinical features, pleocytosis, CSF Bb‐PCR (n = 1), or CSF CXCL13 (n = 2). The proportion with symptoms influencing daily life was 91% pretreatment, 25% at 10 weeks, 20% at 6 months, and 15% at 12 months. Fatigue was the most common complaint at 12 months. A high burden of symptoms before and after treatment was associated with residual complaints at 12 months, whereas background data, other clinical features, and laboratory features were not.ConclusionsLNB can present with solely subjective symptoms, especially pain. Many LNB patients have persistent Bb antibodies in serum and CSF. In seronegative LNB, CSF Bb‐PCR and CXCL13 may give diagnostic support. CXCL13 may be persistently positive after treatment in some patients. Most of the clinical improvement occurs during the first 10 weeks. High initial clinical score is associated with poorer outcome.
Long‐term effects of tagging fishes with electronic tracking devices
Authors: Matley Jordan K. , Klinard Natalie V. , Jaine Fabrice R. A. , Lennox Robert J. , Koopman Natalie , Reubens Jan T. , Harcourt Robert G. , Cooke Steven J. , Huveneers Charlie 
Published: September 2024

AbstractTagging fishes with internal or external electronic tracking devices (acoustic, radio, satellite, or archival tags) is invaluable to behavioural, ecological, and welfare research, but may have adverse effects on the animals studied. While short‐term responses to tagging (e.g., days to weeks) have often been investigated, less information is available on longer‐term impacts (e.g., months to years) and the potential chronic effects of tagging on basic biological needs such as foraging and reproduction. Here, we synthesize existing knowledge from peer‐reviewed acoustic, radio, satellite, and archival tagging articles (n = 149) and anecdotal accounts (n = 72) from 36 researchers to assess the effects of tagging over prolonged periods. We identified a dearth of research that has specifically measured or quantified the impacts of tagging over a period longer than a few weeks or months (e.g., median experimental study duration = 33 days; n = 120 articles). Nevertheless, there was limited evidence to support a net negative long‐term impact from the implantation or attachment of electronic devices. Considerations and future research directions are discussed with the goal of generating guidance to the research community and minimizing potentially detrimental impacts to study animals. Given the global application and relevance of electronic tagging research to inform conservation and management of fishes, it is imperative for scientists to continue evaluating how tagging procedures affect animal welfare, fate, and the interpretation of tracking data.
Commentary: East Asian Educational Migration as Narrative Quests
Authors: Xu Jing 
Published: September 2024

ABSTRACTI interpret the rich conceptual insights and empirical findings of the special issueChildhood, Migration and the Pursuit of Happiness in Middle‐Class East Asiathrough the lens of understanding migration as a journey of narrative quests. Drawing from moral philosopher McIntyre's theory of narrative self and the pursuit of a good life, I highlight the dialectic and dialogic aspects of ‘narrative quests’ across multiple cases of East Asian educational migration (educational migration broadly construed). I highlight key features, central themes and tensions of narrative quests among these migrant families. I also pose questions for expanding further inquiry under this theoretical framework.
Consumer's Cultured Meat Perception and Acceptance Determinants: A Systematic Review and Future Research Agenda
Authors: Hanan Firdaus Abd , Karim Shahrim Ab , Aziz Yuhanis Ab , Ishak Farah Adibah Che , Sumarjan Norzuwana 
Published: September 2024

ABSTRACTThe reliance on animal husbandry for protein has caused environmental, social and ethical challenges worldwide, yet the demand for animal‐based food continues to rise. Despite the increasing attention from scholars and professionals on the potential of cultured meat (CM) as a viable alternative protein source, the ensuing scholarly work still lacks coherence and is incomplete and fragmented. Its success also depends heavily on customer acceptance. This study therefore examined peer‐reviewed literature on consumers' perceptions and acceptance of CM. A comprehensive search was conducted on ScienceDirect, Google Scholar and Scopus databases between 2017 and 2022, yielding 54 papers that met the selection criteria. The qualitative synthesis conducted revealed seven themes that had the highest influence on consumers' acceptance of CM. The themes identified were (i) attitudes and traits, (ii) situational impact, (iii) information and nomenclature, (iv) CM properties, (v) risk–benefit perception, (vi) familiarity and awareness and (vii) competition with other alternative proteins. This review also identified demographic predictors of consumers who are most likely to accept CM. The review found that although consumers are curious and willing to try CM, failure to address personal attitudes and traits may lead to failure in adoption. It was also found that strategies that include emotional responses are more effective in the long run.
Loss of tolerance to dietary proteins: From mouse models to human model diseases
Authors: Levescot Anais , Cerf‐Bensussan Nadine 
Published: September 2024

SummaryThe critical importance of the immunoregulatory mechanisms, which prevent adverse responses to dietary proteins is demonstrated by the consequences of their failure in two common but distinct human pathological conditions, food allergy and celiac disease. The mechanisms of tolerance to dietary proteins have been extensively studied in mouse models but the extent to which the results in mice can be extrapolated to humans remains unclear. Here, after summarizing the mechanisms known to control oral tolerance in mouse models, we discuss how the monogenic immune disorders associated with food allergy on the one hand, and celiac disease, on the other hand, represent model diseases to gain insight into the key immunoregulatory pathways that control immune responses to food antigens in humans. The spectrum of monogenic disorders, in which the dysfunction of a single gene, is strongly associated with TH2‐mediated food allergy suggests an important overlap between the mechanisms that regulate TH2 and IgE responses to food antigens in humans and mice. In contrast, celiac disease provides a unique example of the link between autoimmunity and loss of tolerance to a food antigen.
Textured Sr2Nb2O7 ceramics: Microstructure design, high temperature ferroelectric and piezoelectric performance
Authors: Shao Fenghong , Chen Chen , He Xiang , Wang Lu , Boda Muzaffar Ahmad , Yi Zhiguo 
Published: September 2024

AbstractSr2Nb2O7 (SNO) ceramics are promising high‐temperature piezoelectric materials due to their high Curie temperature (TC), good thermal stability, and high electrical resistivity. However, SNO presents low piezoelectric activity (d33 < 1 pC/N). Here, we successfully obtain textured SNO ceramics with an orientation factor of 0.86 by microstructure regulation. Saturated polarization‐electric loop was obtained in textured ceramic with remanent polarization Pr∼3.56 µC/cm2 and coercive field EC∼53.4 kV/cm. The piezoelectric coefficient d33 of the textured SNO ceramics is increased to 3.2 pC/N, with a high TC of 1342°C, while the low‐textured SNO ceramics exhibit no effective d33. Meanwhile, the piezoelectric coefficient d33 of textured SNO ceramics maintains consistency even at 1300°C, showing excellent thermal stability. The underlying mechanism driving this improvement is elucidated, emphasizing the facilitated domain‐wall motion enabled by the engineered microstructure. Furthermore, textured SNO ceramics exhibit high resistivity of 1.33 × 106 Ω⋅cm at 800°C. This study presents a simple and feasible microstructure engineering approach to enhance the piezoelectric properties of layer‐structured materials, offering valuable insights into the design and development of ceramics for diverse applications.
Multiple positive points during the 75 g oral glucose tolerance test are good predictors for early insulin therapy in gestational diabetes mellitus diagnosed before 24 gestational weeks
Authors: Kasuga Yoshifumi , Takahashi Marina , Kajikawa Kaoru , Akita Keisuke , Tamai Junko , Fukuma Yuka , Tanaka Yuya , Hasegawa Keita , Otani Toshimitsu , Ikenoue Satoru , Tanaka Mamoru 
Published: September 2024

ABSTRACTAims/IntroductionThis study evaluated the risk factors for insulin therapy before 24 gestational weeks (early insulin therapy) in pregnant women with gestational diabetes diagnosed before 24 gestational weeks (E‐GDM).Materials and MethodsThis study included 530 singleton mothers with E‐GDM who underwent a 75 g oral glucose tolerance test (OGTT) in the first trimester at Keio University Hospital between January 2013 and December 2021. E‐GDM can be classified according to its management into only diet therapy until delivery (Diet E‐GDM), insulin therapy started before 24 gestational weeks (EarlyIns E‐GDM), and insulin therapy started after 24 gestational weeks (LateIns E‐GDM). We analyzed the risk factors for EarlyIns E‐GDM.ResultsPatients with EarlyIns E‐GDM had a significantly higher maternal age at delivery, pre‐pregnancy BMI, first trimester hemoglobin A1c, 1 h plasma glucose levels (1 h‐PG), and 2 h‐PG, as well as a more pronounced initial increase and subsequent decrease, compared with those in the Diet E‐GDM group. However, the Apgar scores at both 1 and 5 min were significantly lower in patients with EarlyIns E‐GDM than in those with Diet E‐GDM. The number of abnormal values in the OGTT showed the largest area under the receiver operating characteristic curve (AUC) for predicting EarlyIns E‐GDM (0.83, 95% confidence interval [CI]: 0.79–0.86), followed by the 1 h‐PG value (AUC: 0.81, 95% CI: 0.77–0.85). The initial increase showed the third largest AUC (0.78, 95% CI: 0.74–0.82).ConclusionsAlthough further research is needed, our data suggest the importance of early insulin therapy in cases of E‐GDM with multiple abnormal OGTT values, especially with high 1 h‐PG levels and initial increase.