bluuebunny/crossref_metadata_2025_split huggingface dataset:
Right ventricular dysfunction in left‐sided heart failure with preserved versus reduced ejection fraction
Authors: Bosch Lena , Lam Carolyn S.P. , Gong Lingli , Chan Siew Pang , Sim David , Yeo Daniel , Jaufeerally Fazlur , Leong Kui Toh Gerard , Ong Hean Yee , Ng Tze Pin , Richards Arthur Mark , Arslan Fatih , Ling Lieng H. 
Published: June 2017

AbstractBackgroundRight ventricular (RV) dysfunction is recognized as a major prognostic factor in left‐sided heart failure (HF). However, the relative contribution of RV dysfunction in HF with preserved (HFpEF) vs. reduced ejection fraction (HFrEF) is unclear.Methods and resultsRight ventricular longitudinal strain (RVLS), tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) were determined by echocardiography in 657 age‐ and gender‐matched groups of patients with HFpEF [left ventricular ejection fraction (LVEF) ≥50%; n=219] and HFrEF (LVEF <50%; n=219) and in controls without HF (n=219) from an Asian population‐based cohort study. Across control to HFpEF and HFrEF groups, RV function deteriorated as measured by RVLS (−26.7 ± 5%, −22.7±6.6% and −18.2 ± 6.7%, respectively) and TAPSE (21.0 ± 3.9, 17.5 ± 5.1 and 14.7 ± 4.7 mm, respectively), whereas PASP increased (26.8 ± 7.1, 34.5 ± 11.9 and 39.3 ± 16.2 mmHg, respectively) (all P<0.001). Controlling for PASP in control, HFpEF and HFrEF subjects, the magnitude of RVLS/PASP (−1.06 ± 0.32, −0.75 ± 0.32 and −0.56 ± 0.36, respectively) and TAPSE/PASP ratios (0.83 ± 0.23, 0.54 ± 0.24 and 0.55 ± 0.29, respectively) similarly decreased across groups. Right ventricular dysfunction (by both TAPSE and RVLS) was independently associated with left ventricular systolic dysfunction and atrial fibrillation, but not with PASP. Among patients with HF, both TAPSE/PASP and RVLS/PASP ratios were related to the composite endpoint of all‐cause death and HF hospitalization, even after multivariable adjustment [hazard ratio (HR) 0.33; 95% confidence interval (CI) 0.14–0.74 and HR 3.09; 95% CI 1.52–6.26, respectively], with no difference between HFrEF and HFpEF.ConclusionsRight ventricular dysfunction is present in HFpEF and is even more pronounced in HFrEF for any given degree of pulmonary hypertension. It is independently predicted by left ventricular dysfunction but not by PASP. Right ventricular–arterial coupling is prognostically important in HF regardless of LVEF.
BTN3A1‐antibodies and phosphoantigens: TCRVγ9Vδ2 “see” the difference
Authors: Franchini Don‐Marc , Michelas Marie , Lanvin Olivia , Poupot Mary , Fournié Jean Jacques 
Published: June 2017

Human blood γδ T lymphocytes express TCRVγ9Vδ2 and respond to nonpeptide phosphoantigens (PAgs) by a mysterious mechanism involving the BTN3A1 (CD277) molecule . BTN3A1 is a butyrophilin‐like protein related to CD80, PD‐L1, and MHC, and is either a presenting or a co‐stimulatory molecule for PAgs. Although the precise roles and molecular interactions with the TCRVγ9Vδ2 are currently not determined, it is commonly thought that all TCRVγ9Vδ2 lymphocytes ‘see’ PAg and BTN3A1 together, presumably in a single molecular recognition event. But whether this recognition event could be reproduced in a simplified model was not addressed in previous studies. In this issue, Starick et al. (Eur. J. Immunol. 2017. 47: 982–992) compared the response of three TCRVγ9Vδ2 pairs of murine and human cell transfectants to PAg and anti‐BTN3A1 antibodies using IL‐2 release as a readout. The authors found that although the two murine transfectants responded similarly to either stimuli, one murine TCRVγ9Vδ2 transfectant reacted to PAgs but not to anti‐BTN3A1 (mAb 20.1). Human transductants behave in a similar fashion, demonstrating that TCRVγ9Vδ2 lymphocytes differentiate PAg and BTN3A1 signals, while species of the transductants unmask this differential sensitivity. Indeed, understanding the puzzling mode of antigen recognition by γδ T lymphocytes will be essential for developing γδ T‐cell‐based immunotherapies, and the authors of this study now demonstrate that TCRVγ9Vδ2 lymphocytes are able to differentiate the PAg and BTN3A1 stimuli.
Manufacturing of Perovskite Oxygen Carriers by Spray Granulation for Chemical Looping Combustion
Authors: Thoréton Vincent , Darell Ove , Spjelkavik Aud I. , Sunding Martin Fleissner , Mokkelbost Tommy , Pishahang Mehdi , Wiik Kjell , Larring Yngve 
Published: June 2017

AbstractChemical looping combustion is a technology under development that allows power production with inherent separation of CO2 during fuel combustion. Its principle relies on oxygen carrier materials transporting oxygen from air to oxidize the fuel. One challenge is to develop and produce materials with suitable chemical and physical properties, as well as low environmental impact, while minimizing the cost of production. Herein, it is demonstrated that spray granulation, which is a scalable industrial process, is relevant for the manufacture of promising oxygen carrier materials from low‐cost, low‐environmental‐impact minerals and with good mechanical properties: Ca0.98Mn0.875Ti0.125O3 and Ca0.98Mn0.75Fe0.125Ti0.125O3. Iron substitution clearly reduces the sintering time. Increasing the calcination temperature and calcination time enhances the bulk density and resistance against physical attrition.
A comparison of four porewater sampling methods for metal mixtures and dissolved organic carbon and the implications for sediment toxicity evaluations
Authors: Cleveland Danielle , Brumbaugh William G. , MacDonald Donald D. 
Published: June 2017

Abstract

Evaluations of sediment quality conditions are commonly conducted using whole-sediment chemistry analyses but can be enhanced by evaluating multiple lines of evidence, including measures of the bioavailable forms of contaminants. In particular, porewater chemistry data provide information that is directly relevant for interpreting sediment toxicity data. Various methods for sampling porewater for trace metals and dissolved organic carbon (DOC), which is an important moderator of metal bioavailability, have been employed. The present study compares the peeper, push point, centrifugation, and diffusive gradients in thin films (DGT) methods for the quantification of 6 metals and DOC. The methods were evaluated at low and high concentrations of metals in 3 sediments having different concentrations of total organic carbon and acid volatile sulfide and different particle-size distributions. At low metal concentrations, centrifugation and push point sampling resulted in up to 100 times higher concentrations of metals and DOC in porewater compared with peepers and DGTs. At elevated metal levels, the measured concentrations were in better agreement among the 4 sampling techniques. The results indicate that there can be marked differences among operationally different porewater sampling methods, and it is unclear if there is a definitive best method for sampling metals and DOC in porewater. Environ Toxicol Chem 2017;36:2906–2915. Published 2017 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
Mining industry and sustainable development: time for change
Authors: Carvalho Fernando P. 
Published: June 2017

AbstractMining industries provide most of the materials we rely on to build infrastructures and instruments of daily use, to obtain large amounts of energy, and to supply agriculture with fertilizers that enable most of foods produced. At the same time, mining is the human activity that has been more disturbing to environment and is linked to large social impacts and inequalities. Notwithstanding, our future is deeply depending on mining. Several mining sectors, from phosphate to uranium, are reviewed and their current impacts and challenges are discussed. The mining legacy and environmental remediation, the present mining and challenges, and the future mining and society are discussed in relationship with environmental health and sustainable development. It is concluded that current mining practices need to change and contribute to community development with more equity, and to protect better natural resources and ecosystems in order to be environmentally acceptable and compliant with sustainable development objectives.
Impedance and Raman Spectroscopy Study of Effect of H2S on Ni‐YSZ SOFC Anodes
Authors: Mai Thi H. H. , Rosman N. , Sergent N. , Pagnier T. 
Published: June 2017

AbstractThe electrical behavior of a Ni‐YSZ anode of a solid oxid fuel cell (SOFC) cell under H2S has been monitored by impedance spectroscopy combined with in situ Raman spectroscopy and post mortem scanning electron microscopy (SEM) at 500 °C in open circuit potential (OCP) and at 500 mV polarization. In OCP condition, the electrode impedance spectra evolved slowly corresponding quite well to the evolution of Raman signals' intensities. Meanwhile, at 500 mV polarization, the impedance spectra transformed much faster, indicating a quick and severe H2S‐induced poisoning, which is then confirmed by post mortem examinations by SEM with the densification of the bulk anode porous structure with (Ni, S) phase. Based on the experimental data, the elementary steps and location of H2 oxidation are discussed.
Copy number alterations determined by single nucleotide polymorphism array testing in the clinical laboratory are indicative of gene fusions in pediatric cancer patients
Authors: Busse Tracy M. , Roth Jacquelyn J. , Wilmoth Donna , Wainwright Luanne , Tooke Laura , Biegel Jaclyn A. 
Published: June 2017

AbstractGene fusions resulting from structural rearrangements are an established mechanism of tumorigenesis in pediatric cancer. In this clinical cohort, 1,350 single nucleotide polymorphism (SNP)‐based chromosomal microarrays from 1,211 pediatric cancer patients were evaluated for copy number alterations (CNAs) associated with gene fusions. Karyotype or fluorescence in situ hybridization studies were performed in 42% of the patients. Ten percent of the bone marrow or solid tumor specimens had SNP array‐associated CNAs suggestive of a gene fusion. Alterations involving ETV6, ABL1‐NUP214, EBF1‐PDGFRB, KMT2A(MLL), LMO2‐RAG, MYH11‐CBFB, NSD1‐NUP98, PBX1, STIL‐TAL1, ZNF384‐TCF3, P2RY8‐CRLF2, and RUNX1T1‐RUNX1 fusions were detected in the bone marrow samples. The most common alteration among the low‐grade gliomas was a 7q34 tandem duplication resulting in a KIAA1549‐BRAF fusion. Additional fusions identified in the pediatric brain tumors included FAM131B‐BRAF and RAF1‐QKI. COL1A1‐PDGFB, CRTC1‐MAML2, EWSR1, HEY1, PAX3‐ and PAX7‐FOXO1, and PLAG1 fusions were determined in a variety of solid tumors and a novel potential gene fusion, FGFR1‐USP6, was detected in an aneurysmal bone cyst. The identification of these gene fusions was instrumental in tumor diagnosis. In contrast to hematologic and solid tumors in adults that are predominantly driven by mutations, the majority of hematologic and solid tumors in children are characterized by CNAs and gene fusions. Chromosomal microarray analysis is therefore a robust platform to identify diagnostic and prognostic markers in the clinical setting.
Hippocampal neurogenesis and pattern separation: A meta‐analysis of behavioral data
Authors: França Thiago F. A. , Bitencourt Alexandre M. , Maximilla Naiana R. , Barros Daniela M. , Monserrat José M. 
Published: June 2017

AbstractThe generation of new neurons in the hippocampus of adult mammals has become a widely accepted phenomenon, but the functional significance of the adult neurogenesis in the hippocampus is not fully understood. One of the main hypotheses currently investigated suggests that neurogenesis contributes to pattern separation in the dentate gyrus. Many behavioral studies were conducted aiming to test this hypothesis using rodents as animal model. In those studies, researches ablated neurogenesis in the animals and subsequently evaluate them in tests of behavioral pattern separation, that is, behaviors that are thought to rely on the computational process of pattern separation. The results of these studies are varied, with most supporting a role for neurogenesis in pattern separation, but some others not. To address this controversy we performed a systematic review and meta‐analysis of studies evaluating the effect of neurogenesis ablation on behavioral pattern separation. Analysis results indicated that most of the literature in the topic is surprisingly consistent and, although there are two studies with divergent results, the bulk of the literature supports an effect of hippocampal neurogenesis on behavioral pattern separation. We discuss those findings in light of other behavioral effects of hippocampal neurogenesis ablation, limitations of behavioral data and other lines of evidence about the effect of hippocampal neurogenesis in the dentate gyrus.
Predator odor evokes sex‐independent stress responses in male and female Wistar rats and reduces phosphorylation of cyclic‐adenosine monophosphate response element binding protein in the male, but not the female hippocampus
Authors: Homiack Damek , O'Cinneide Emma , Hajmurad Sema , Barrileaux Brett , Stanley Mary , Kreutz Michael R. , Schrader Laura A. 
Published: June 2017

AbstractPost‐traumatic stress disorder (PTSD) is characterized by memory disturbances following trauma. Acute predator threat has emerged as an ethological model of PTSD, yet the effects of predator odor on signaling cascades associated with long‐term memory remain poorly understood. In this study, we exposed male and female Wistar rats to the synthetic predator odor 2,5‐dihydro‐2,4,5‐trimethylthiazoline (TMT) to assess behavioral and physiological responses as well as rapid modulation of signal transduction cascades associated with learning and memory in the male and female hippocampus. During exposure to TMT in the homecage, both male and female animals displayed robust immobility, avoidance, and altered activity as a function of time. Physiologically, TMT exposure increased circulating corticosterone and blood glucose in both male and female rodents, suggesting that TMT evokes sex‐independent behavioral and physiological responses. With respect to signal transduction, TMT exposure rapidly reduced phosphorylation of cyclic‐adenosine monophosphate response element binding protein (CREB) in the male, but not the female hippocampus. Furthermore, TMT exposure reduced phosphorylation of extracellular signal‐regulated kinase 1/2 and increased nuclear expression of the synapto‐nuclear messenger protein Jacob in the male hippocampus, consistent with activation of the CREB shut‐off pathway. In a follow‐up behavioral experiment, post‐training exposure to TMT did not affect spatial water maze performance of male rats. However, male rats re‐introduced to the context in which TMT had previously been presented displayed avoidance and hyperactivity, but not freezing behavior or elevated corticosterone responses, suggesting that TMT exposure supports a form of contextual conditioning which is not characterized by immobility. Taken together, our findings suggest that TMT evokes similar behavioral and physiological responses in male and female Wistar rats, but affects distinct signaling cascades in the male and female hippocampus which may contribute to behavioral disruptions associated with predator exposure.
Pharmaco‐toxicological effects of the novel third‐generation fluorinate synthetic cannabinoids, 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 in mice. In vitro and in vivo studies
Authors: Canazza Isabella , Ossato Andrea , Vincenzi Fabrizio , Gregori Adolfo , Di Rosa Fabiana , Nigro Federica , Rimessi Alessandro , Pinton Paolo , Varani Katia , Borea Pier Andrea , Marti Matteo 
Published: June 2017

Introduction5F‐ADBINACA, AB‐FUBINACA, and STS‐135 are 3 novel third‐generation fluorinate synthetic cannabinoids that are illegally marketed as incense, herbal preparations, or research chemicals for their psychoactive cannabis‐like effects.MethodsThe present study aims at investigating the in vitro and in vivo pharmacological activity of 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 in male CD‐1 mice, comparing their in vivo effects with those caused by the administration of Δ9‐THC and JWH‐018. In vitro competition binding experiments revealed a nanomolar affinity and potency of the 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 on mouse and human CB1 and CB2 receptors. Moreover, these synthetic cannabinoids induced neurotoxicity in murine neuro‐2a cells.ResultsIn vivo studies showed that 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 induced hypothermia; increased pain threshold to both noxious mechanical and thermal stimuli; caused catalepsy; reduced motor activity; impaired sensorimotor responses (visual, acoustic, and tactile); caused seizures, myoclonia, and hyperreflexia; and promoted aggressiveness in mice. Behavioral and neurological effects were fully prevented by the selective CB1 receptor antagonist/inverse agonist AM 251. Differently, the visual sensory response induced by STS‐135 was only partly prevented by the AM 251, suggesting a CB1‐independent mechanism.ConclusionsFor the first time, the present study demonstrates the pharmaco‐toxicological effects induced by the administration of 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 in mice and suggests their possible detrimental effects on human health.
Improvement of Giant Cell Lesions of the Jaw Treated With High and Low Doses of Denosumab: A Case Series
Authors: Kim Tara S , Usera Gianina L , Ruggiero Salvatore L , Weinerman Stuart A 
Published: June 2017

AbstractGiant cell tumors (GCTs) and central giant cell granulomas (CGCGs) are aggressive lesions that appear in the jaw. These lesions occur in the second and third decades of life and often arise in the mandible. Clinical manifestations of these lesions vary from asymptomatic to symptomatic tooth displacement with cortical perforation. GCTs, which are characterized by multinucleated osteoclast‐type giant cells that express receptor activator of nuclear factor‐κB (RANK) ligand, rarely present in the jaw and have overlapping histopathologic features with CGCGs, which are composed of fibroblastic stromal cell lesions. GCTs and CGCGs have overlying histopathologic features that make distinction between the two challenging. There is a real controversy as to whether giant cell tumors and central giant cell granulomas are in fact, one and the same lesion. The majority of GCTs occur in the long bone, with surgery being the typical therapeutic option. Denosumab as a treatment modality is a fairly new concept that has been used effectively in GCTs affecting long bones. There is less experience, however, with its use for jaw lesions. This seven‐case series describes the effective use of both low‐dose and high‐dose denosumab in the treatment of GCTs and CGCGs affecting the jaw and special dosing considerations for younger patients who present with disease. © 2017 The Authors. JBMR Plus Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.
Association of a reactive intermediate derived from 1′,6‐dihydroxy metabolite with benzbromarone‐induced hepatotoxicity
Authors: Yoshida Mina , Cho Naoki , Akita Hidetaka , Kobayashi Kaoru 
Published: June 2017

AbstractTreatment with benzbromarone can be associated with liver injury, but the detailed mechanism remains unknown. Our recent studies demonstrated that benzbromarone was metabolized to 1′,6‐dihydroxybenzbromarone and followed by formation of reactive intermediates that were trapped by glutathione, suggesting that the reactive intermediates may be responsible for the liver injury. The aim of this study was to clarify whether the reactive intermediates derived from 1′,6‐dihydroxybenzbromarone is a risk factor of liver injury in mice. An incubation study using mouse liver microsomes showed that the rates of formation of 1′,6‐dihydroxybenzbromarone from benzbromarone were increased by pretreatment with dexamethasone. Levels of a hepatic glutathione adduct derived from 1′,6‐dihydroxybenzbromarone were increased by pretreatment with dexamethasone. Furthermore, plasma alanine amino transferase activities were increased in mice treated with benzbromarone after pretreatment with dexamethasone. The results suggest that the reactive intermediate derived from 1′,6‐dihydroxybenzbromarone may be associated with liver injury.
Peptidomic Analysis of Maternal Serum to Identify Biomarker Candidates for Prenatal Diagnosis of Tetralogy of Fallot
Authors: Zhuang Bin , Hu Yin , Fan Xuemei , Li Mengmeng , Zhu Jingai , Liu Heng , Cao Li , Liang Dong , Zhang Jingjing , Yu Zhangbin , Han Shuping 
Published: June 2017

ABSTRACTTetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. To identify endogenous peptides possibly involved in the progression of TOF, we performed comparative peptidomic profiling of maternal serum between normal fetuses and fetuses suffering from TOF. A total of 278 differentially expressed peptides, including 94 over‐expressed peptides and 184 under‐expressed peptides, originating from 227 protein precursors were identified by liquid chromatography/mass spectrometry (LC/MS) in maternal serum of fetuses with TOF compared to normal controls. Further, ingenuity pathway analysis (IPA) was used to identify putative roles for these peptides in cardiovascular development. Two peptides were derived from functional domains of proteins involved in heart development and associated with TOF; these may represent candidate bioactive peptides involved in TOF. These peptides may be related to the pathologic changes in the heart associated with TOF, and may be useful as novel biomarkers for prenatal diagnosis of TOF. J. Cell. Biochem. 119: 468–477, 2018. © 2017 Wiley Periodicals, Inc.
Altered Expression of MicroRNAs in Rheumatoid Arthritis
Authors: Tavasolian Fataneh , Abdollahi Elham , Rezaei Ramin , Momtazi‐borojeni Amir Abbas , Henrotin Yves , Sahebkar Amirhossein 
Published: June 2017

ABSTRACTRheumatoid arthritis is one of the most common types of inflammatory joint diseases. Women, smokers, and people with positive family history are more susceptible to this disease. Diagnostic criteria include at least one swollen joint that has not been caused by other diseases. MicroRNAs are non‐coding RNAs that are evolutionarily conserved and have a length of 18–25 nucleotides. MicroRNAs control gene expression at the post‐transcriptional level via promoting mRNA degradation or translational repression. Recognition of alterations in microRNA status and their respective targets, may offer an opportunity to better identify the pathways that are involved in the etiopathogenesis of autoimmune diseases. It has been suggested that microRNAs may serve as potential biomarkers for both diagnosis and prognosis of autoimmune diseases. Here, we review the available evidence on the deregulations of microRNA expression in rheumatoid arthritis. More precisely, this review focuses on the microRNA involved in T cell regulation and gives perspectives on the use of this microRNA as biomarkers of diagnosis, prognosis, or intervention efficacy. J. Cell. Biochem. 119: 478–487, 2018. © 2017 Wiley Periodicals, Inc.