bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole‐exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women
Authors: Li Xia , Huang Hailiang , Guan Yanfang , Gong Yuhua , He Cheng‐Yi , Yi Xin , Qi Ming , Chen Zhi‐Ying 
Published: December 2016

AbstractEmerging evidence suggest that the heterogeneity of cancer limits the efficacy of immunotherapy. To search for optimal therapeutic targets for enhancing the efficacy, we used whole‐exome sequencing data of 23 early cervical tumors from Chinese women to investigate the hierarchical structure of the somatic mutations and the neo‐epitopes. The putative neo‐epitopes were predicted based on the mutant peptides’ strong binding with major histocompatibility complex class I molecules. We found that each tumor carried an average of 117 mutations and 61 putative neo‐epitopes. Each patient displayed a unique phylogenetic tree in which almost all subclones harbored neo‐epitopes, highlighting the importance of individual neo‐epitope tree in determination of immunotherapeutic targets. The alterations in FBXW7 and PIK3CA, or other members of the significantly altered ubiquitin‐mediated proteolysis and extracellular matrix receptor interaction related pathways, were proposed as the earliest changes triggering the malignant progression. The neo‐epitopes involved in these pathways, and located at the top of the hierarchy tree, might become the optimal candidates for therapeutic targets, possessing the potential to mediate T‐cell killing of the descendant cells. These findings expanded our understanding in early stage of cervical carcinogenesis and offered an important approach to assist optimizing the immunotherapeutic target selection.
How Diverse Is This Community? Sense of Community, Ethnic Prejudice and Perceived Ethnic Heterogeneity
Authors: Mannarini Terri , Talò Cosimo , Rochira Alessia 
Published: December 2016

AbstractIn this paper, the relationship between territorial sense of community (SoC), perceived ethnic heterogeneity within the community and ethnic prejudice was analyzed. Specifically, the moderating role of perceived ethnic heterogeneity within the community on the SoC–prejudice relationship was tested in a sample of residents (N = 603) of the Salento region, Italy. Results showed that the relationship between SoC and prejudice was moderated by perceived contextual heterogeneity. For blatant and subtle prejudice, when perceived ethnic heterogeneity was low, SoC was negatively associated with prejudice. In the case of modern prejudice, SoC was positively associated with prejudice when perceived ethnic heterogeneity was high. Copyright © 2016 John Wiley & Sons, Ltd.
Managing infected cardiovascular implantable electronic devices
Authors: Manolis A. S. , Melita H. 
Published: December 2016

AbstractThe number of cardiac implantable electronic device (CIED) implants is growing; unfortunately, the rate of device infections is also rising, outpacing the increase in device implantation and paralleling the complexity of current CIEDs and CIED recipients, incurring high morbidity and mortality, long hospital stays, and increased financial cost. For either pocket or lead infection, percutaneous complete removal of the infected device and lead system combined with prolonged antibiotic treatment is the standard approach to patient management. A variety of mechanical and/or laser‐assisted techniques and tools are employed with high success rates in experienced centers. Surgery is reserved for cases with very large vegetations, need for other concomitant cardiac surgery or for failed or complicated percutaneous approach. Following removal of an infected CIED, the need for reimplantation of a new device is individualized, although the timing is variable, mainly based on the absence of signs of continued infection. In general, CIED‐related infective endocarditis and the presence of comorbid conditions are associated with increased mortality. These and other important relevant issues of contemporary management of patients with infected CIEDs are herein reviewed.Answer questions and earn CME: https://wileyhealthlearning.com/Activity2/4596336/Activity.aspx
Remote monitoring of patients with CIEDs following the updated recommendations—Easing or adding to postimplant responsibilities?
Authors: Varma N. 
Published: December 2016

AbstractFollow‐up of patients with cardiac implantable electronic devices is challenging due to both their increasing volume and technical complexity coupled to increasing clinical complexity of recipient patients. Remote monitoring (RM) offers an opportunity to resolve some of these difficulties by improving clinic efficiencies and providing a mechanism for device monitoring and patient management. Recent recommendations advocate for RM to be standard of care for this purpose. Several randomized clinical trials and registries have demonstrated that RM may reduce in‐hospital visit numbers, time required for patient follow‐up, physician and nurse time, and hospital and social costs. Furthermore, patient retention and adherence to follow‐up schedule are significantly improved by RM. Continuous wireless monitoring of data stored in the device memory with automatic alerts allows early detection of device malfunctions and of events, such as atrial fibrillation, ventricular arrhythmias, and heart failure suitable for clinical intervention. Early reaction may improve patient outcome. RM is easy to use and patients showed a high level of acceptance and satisfaction. Implementing RM in daily practice may require changes in clinic workflow. New organizational models promote significant efficiencies regarding physician and nursing time. Data management techniques are under development. Despite these demonstrable advantages of RM, adoption still remains modest, even in health care systems incentivized to use this follow‐up method.Answer questions and earn CME: https://wileyhealthlearning.com/Activity2/4596352/Activity.aspx.
Extensive cutaneous metastases of pancreatic adenocarcinoma: a case report and review of the literature
Authors: Kotsantis Ioannis , Economopoulou Panagiota , Dritsakos Konstantinos , Oikonomopoulos Nikolaos , Bakogeorgos Marios , Rapti Cleopatra , Kentepozidis Nikolaos 
Published: December 2016

Key Clinical MessageHerein, we present the case of a patient with pancreatic cancer and nonumbilical cutaneous metastasis. Patients with pancreatic adenocarcinomas can develop extensive cutaneous metastases involving not only abdominal skin but also other unusual sites such as the scrotum.
Interfacial Architectures Derived by Lithium Difluoro(bisoxalato) Phosphate for Lithium‐Rich Cathodes with Superior Cycling Stability and Rate Capability
Authors: Han Jung‐Gu , Park Inbok , Cha Jiho , Park Suhyeon , Park Sewon , Myeong Seungjun , Cho Woograe , Kim Sung‐Soo , Hong Sung You , Cho Jaephil , Choi Nam‐Soon 
Published: December 2016

AbstractThe front cover artwork is provided by the group of Nam‐Soon Choi at Ulsan National Institution Science Technology, Republic of Korea. The image shows lithium difluoro(bisoxalato) phosphate as an oxidizable additive for in‐situ formation of a stable artificial solid electrolyte interphase layer on the Li‐rich cathode. Read the full text of the Article at 10.1002/celc.201600297.
Rhodium‐Catalyzed Synthesis and Optical Properties of Silicon‐Bridged Arylpyridines
Authors: Shintani Ryo , Misawa Nana , Takano Ryo , Nozaki Kyoko 
Published: December 2016

AbstractA convergent and regioselective synthesis of silicon‐bridged 4‐arylpyridines has been developed through a rhodium‐catalyzed [2+2+2] cycloaddition of silicon‐containing diynes with nitriles. The absorption and emission properties of these compounds have been examined and could be tuned by varying the substituent on the benzene ring, as well as through the protonation or alkylation of the nitrogen atom on the pyridine ring. A catalytic asymmetric synthesis of silicon‐centered axially chiral spirocyclic derivatives has also been achieved with high enantioselectivity by using a newly modified MeO‐MOP (MeO‐MOP=2‐(diphenylphosphino)‐2′‐methoxy‐1,1′‐binaphthyl) derivative as the chiral ligand. These spirocyclic compounds were found to be CPL‐active (CPL=circularly polarized luminescence), representing the first CPL‐active compounds based on the chirality at silicon.
Intramolecular Diaza‐Diels–Alder Protocol: A New Diastereoselective and Modular One‐Step Synthesis of Constrained Polycyclic Frameworks
Authors: Srinivasulu Vunnam , Reddy Amarnath , Mazitschek Ralph , Lukens Amanda K. , Wirth Dyann F. , Li Liang , Naumov Panče , O'Connor Matthew John , Al‐Tel Taleb H. 
Published: December 2016

AbstractPhenotype‐based screening of diverse compound collections generated by privileged substructure‐based diversity‐oriented synthesis (pDOS) is considered one of the prominent approaches in the discovery of novel drug leads. However, one key challenge that remains is the development of efficient and modular synthetic routes toward the facile access of privileged small‐molecule libraries with skeletal and stereochemical complexity and drug‐like properties. In this regard, a novel and diverse one‐pot procedure for the diastereoselective synthesis of privileged polycyclic benzopyrans and benzoxepines is described herein. These unexplored chemotypes were accessed by utilizing an acid‐mediated diaza‐Diels–Alder reaction of 2‐allyloxy‐ and/or homoallyloxy benzaldehyde with 2‐aminoazine building blocks. Profiling of representative analogues against blood‐stage Plasmodium falciparum parasites identified three lead candidates with low micromolar antimalarial activity.
Homogeneous and Heterogeneous Anion Sensing by a Molecular Cobalt–Vanadium Oxide
Authors: Heiland Magdalena , Seliverstov Andrey , Schwarz Benjamin , Anjass Montaha H. , Streb Carsten 
Published: December 2016

AbstractSpectroscopic anion sensing is a vital non‐invasive tool in chemistry and biology. Here, a molecular cobalt–vanadium‐oxide cluster was shown to be capable of selectively binding and detecting various mono‐anions in solution and immobilized on a solid support. The cluster anion [Co(X)V4O12]3− (X=mono‐anion, for example, halide, pseudohalide, carboxylate, etc.) was formed spontaneously upon anion addition by self‐assembly in solution. The cluster showed distinct spectral changes upon anion binding that could be followed spectroscopically and visually owing to a significant change of the solution color. DFT computations showed that the anion binding observed experimentally was correlated to the relative cluster stabilities. Competitive‐binding studies showed that selective anion binding was possible from a mixture of anions. Immobilization of the anion sensor on silica strips provided access to single‐use dip‐stick sensors for the facile detection of anions in solution. The system presented enables the development of homogeneous or heterogeneous molecular anion sensors with possible applications in chemistry, bio‐medical scenarios, and under harsh environmental conditions.
Divergent Iron‐Catalyzed Coupling of O‐Acyloximes with Silyl Enol Ethers
Authors: Yang Hai‐Bin , Selander Nicklas 
Published: December 2016

AbstractAn iron‐catalyzed coupling reaction of O‐acyloximes and O‐benzoyl amidoximes with silyl enol ethers is reported. The protocol provides access to functionalized pyrroles, 1,6‐ketonitriles, pyrrolines and imidazolines via carbon‐centered radicals generated from an initially formed iminyl radical. The intramolecular cyclization and ring‐opening processes of the iminyl radical take place preferentially over reactions that proceed through a 1,3‐hydrogen transfer, providing insights into iron‐catalyzed reactions with oxime derivatives. The cheap and environmentally friendly iron catalyst, the broad substrate scope and the functional group compatibility make this protocol useful for synthesis of valuable nitrogen‐containing products.
Design, Synthesis and Insecticidal Evaluation of Anthranilic Diamides Containing Optically Pure Amino Acid Moiety
Authors: Zhou Shaa , Zhou Sha , Hua Xuewen , Wei Wei , Xie Yongtao , Chen Minggui , Meng Xiangde , Liu Ming , Xiong Lixia , Yang Na , Wang Baolei , Li Zhengming 
Published: December 2016

AbstractTwo series of N‐pyridylpyrazolecarboxamide derivatives were designed and synthesized by introducing D‐alanine acid esters and D‐serine acid esters into the skelecton of chlorantraniliprole. The obtained structures were characterized by 1H NMR, 13C NMR, elemental analysis and specific optical rotation analysis. Preliminary bioassays indicated that some compounds displayed excellent insecticidal activities against Mythimna separate and Plutella xylostella in comparison with chlorantraniliprole. In particular, IIq showed excellent insecticidal activity against Plutella xylostella with a mortality rate of 90% at 0.01 mg·L−1. A 3D‐QSAR (CoMSIA) study was performed in order to disclose the insecticidal structure‐activity relationship and indicate the future work. The CoMSIA study demonstrated that large substitutes and electron deficient groups at the 3‐position of pyrazole ring are favorable, the same as a small group near the ester groups of amino acid.
Praseodymium Oxide Modified CeO2/Al2O3 Catalyst for Selective Catalytic Reduction of NO by NH3
Authors: Jin Qijie , Shen Yuesong , Zhu Shemin 
Published: December 2016

AbstractA series of CeO2/Al2O3 catalysts was modified with praseodymium oxide using an extrusion method. The catalytic activities of the obtained catalysts were measured for the selective catalytic reduction of NO with NH3 to screen suitable addition of praseodymium oxide. These samples were characterized by XRD, N2‐BET, NH3‐TPD, NO‐TPD, Py‐IR, H2‐TPR, Raman spectra and XPS, respectively. Results showed the optimal catalyst with the Pr/Ce molar ratio of 0.10 exhibited more than 90% NO conversion in a wide temperature range of 290–425°C under GHSV of 5000 h−1. The number of Lewis acid sites and the chemisorbed oxygen concentration of the catalysts would increase with the Pr incorporation, which was favorable for the excellent catalytic performance. In addition, the Pr incorporation inhibited growth of the Al2O3 crystal particles and led to the lattice expansion of CeO2, which increased catalytic activity. The results implied that the higher chemisorbed oxygen concentrations and the more Lewis acid sites were conductive to obtain the excellent SCR activity.
Novel Fluorescent Chemosensor for Detection of F− Anions Based on a Single Functionalized Pillar[5]arene Iron(III) Complex
Authors: Zhang Youming , Su Junxia , Li Qiao , Li Wenting , Liang Guoyan , Li Hui , Ma Haixia , Lin Qi , Yao Hong , Wei Taibao 
Published: December 2016

Abstract Novel fluorescent chemosensor with good selectivity for F− anion was designed and synthesized. The sensor has a bearing on a single functionalized pillar[5]arene and Fe3+ metal complex (PN‐Fe), which showed prominent fluorescent response for F− anion over other common anions (Cl−, Br−, I−, AcO−, HSO4−, H2PO4−, ClO4−, CN− and SCN−). These results were evaluated by fluorescent method. The detection limit of PN‐Fe to F− was calculated to be 2.50×10−7 mol/L. Moreover, the sensor PN‐Fe3+ might serve as a recyclable component in sensing materials.
Photodynamic Therapy Activities of 10‐(4‐Formylphenyl)‐5,15‐bis(pentafluorophenyl)corrole and Its Gallium Complex
Authors: Cheng Fan , Huang Liting , Wang Huahua , Liu Yunjun , Kandhadi Jaipal , Wang Hui , Ji Liangnian , Liu Haiyang 
Published: December 2016

Abstract10‐(4‐Formylphenyl)‐5,15‐bis(pentafluorophenyl)corrole 1 and its gallium complex 1‐Ga were used to investigate their photocytotoxicity in liver cancer (BEL‐7402), lung cancer (A549) and cervical cancer (Siha, Hela) cell lines. Among all the tested tumor cells, Siha tumor cells were the most sensitive to photodynamic therapy (PDT) treatment by 1 and 1‐Ga. PDT IC50 of 1 and 1‐Ga toward Siha tumor cell reaches 1.3 and 0.8 µmol/L respectively, which is 10‐fold higher than that of cisplatin. 1 and 1‐Ga might pass across the tumor cell membrane smoothly without the help of carrier protein, and mainly localized in the cytoplasm of tumor cell. After PDT treatment, the intracellular reactive oxygen species (ROS) level increased and the mitochondrial membrane potential decreased significantly, which would finally result in the apoptosis of tumor cells.
Descending projections from the basal forebrain to the orexin neurons in mice
Authors: Agostinelli Lindsay J. , Ferrari Loris L. , Mahoney Carrie E. , Mochizuki Takatoshi , Lowell Bradford B. , Arrigoni Elda , Scammell Thomas E. 
Published: December 2016

AbstractThe orexin (hypocretin) neurons play an essential role in promoting arousal, and loss of the orexin neurons results in narcolepsy, a condition characterized by chronic sleepiness and cataplexy. The orexin neurons excite wake‐promoting neurons in the basal forebrain (BF), and a reciprocal projection from the BF back to the orexin neurons may help promote arousal and motivation. The BF contains at least three different cell types (cholinergic, glutamatergic, and γ‐aminobutyric acid (GABA)ergic neurons) across its different regions (medial septum, diagonal band, magnocellular preoptic area, and substantia innominata). Given the neurochemical and anatomical heterogeneity of the BF, we mapped the pattern of BF projections to the orexin neurons across multiple BF regions and neuronal types. We performed conditional anterograde tracing using mice that express Cre recombinase only in neurons producing acetylcholine, glutamate, or GABA. We found that the orexin neurons are heavily apposed by axon terminals of glutamatergic and GABAergic neurons of the substantia innominata (SI) and magnocellular preoptic area, but there was no innervation by the cholinergic neurons. Channelrhodopsin‐assisted circuit mapping (CRACM) demonstrated that glutamatergic SI neurons frequently form functional synapses with the orexin neurons, but, surprisingly, functional synapses from SI GABAergic neurons were rare. Considering their strong reciprocal connections, BF and orexin neurons likely work in concert to promote arousal, motivation, and other behaviors. J. Comp. Neurol. 525:1668–1684, 2017. © 2016 Wiley Periodicals, Inc.
Decomposition of Imidazolium‐Based Ionic Liquids in Contact with Lithium Metal
Authors: Schmitz Paulo , Jakelski Rene , Pyschik Marcelina , Jalkanen Kirsi , Nowak Sascha , Winter Martin , Bieker Peter 
Published: December 2016

AbstractIonic liquids (ILs) are considered to be suitable electrolyte components for lithium‐metal batteries. Imidazolium cation based ILs were previously found to be applicable for battery systems with a lithium‐metal negative electrode. However, herein it is shown that, in contrast to the well‐known IL N‐butyl‐N‐methylpyrrolidinium bis[(trifluoromethyl)sulfonyl]imide ([Pyr14][TFSI]), 1‐ethyl‐3‐methylimidazolium bis[(trifluoromethyl)sulfonyl]imide ([C2MIm][TFSI]) and 1‐butyl‐3‐methylimidazolium bis[(trifluoromethyl)sulfonyl]imide ([C4MIm][TFSI]) are chemically unstable versus metallic lithium. A lithium‐metal sheet was immersed in pure imidazolium‐based IL samples and aged at 60 °C for 28 days. Afterwards, the aged IL samples were investigated to deduce possible decomposition products of the imidazolium cation. The chemical instability of the ILs in contact with lithium metal and a possible decomposition starting point are shown for the first time. Furthermore, the investigated imidazolium‐based ILs can be utilized for lithium‐metal batteries through the addition of the solid–electrolyte interphase (SEI) film‐forming additive fluoroethylene carbonate.
One‐Pot Anchoring of Pd Nanoparticles on Nitrogen‐Doped Carbon through Dopamine Self‐Polymerization and Activity in the Electrocatalytic Methanol Oxidation Reaction
Authors: Li Xin , Niu Xiangheng , Zhang Wenchi , He Yanfang , Pan Jianming , Yan Yongsheng , Qiu Fengxian 
Published: December 2016

AbstractExploration of advanced electrocatalysts to promote the sluggish methanol oxidation reaction (MOR) is of vital importance for developing high efficiency and low‐cost direct methanol fuel cells. Highly dispersed palladium nanoparticles (Pd NPs) anchored on a nitrogen‐doped carbon support were fabricated using a facile one‐pot dopamine self‐polymerization mediated redox strategy, in which dopamine not only acted as a moderate reductant to induce the formation of Pd NPs during self‐polymerization but was also the precursor of the nitrogen‐doped carbon support for Pd. The synthesized hybrid features the following characteristics: 1) High dispersity of Pd NPs, which exposed a high abundance of active surfaces and sites for heterogeneous electrocatalysis; 2) metal‐support interactions, which may affect the surface chemistry and electron distribution of active Pd NPs; 3) the Pd NPs were partially imbedded or encapsulated into the support, thus reducing the possible agglomeration of Pd NPs during cyclic measurements. The electrocatalyst with such favorable features provided higher mass activity (2.2 times that of commercial Pd/C) and better durability (reduced loss of activity during simulated frequent startup–shutdown operations) for the MOR in alkaline media.
Comprehensive Mass Cytometry Analysis of Cell Cycle, Activation, and Coinhibitory Receptors Expression in CD4 T Cells from Healthy and HIV‐Infected Individuals
Authors: Corneau Aurélien , Cosma Antonio , Even Sophie , Katlama Christine , Le Grand Roger , Frachet Véronique , Blanc Catherine , Autran Brigitte 
Published: December 2016

RationaleMass cytometry allows large multiplex analysis of cell cycle stages together with differentiation, activation, and exhaustion markers, allowing further assessment of the quiescence status of resting CD4 T cells.MethodsPeripheral blood CD4 T lymphocytes from 8 individuals, 4 healthy donors, and 4 HIV‐infected on antiretroviral treatment (T) were stained with the same 26 monoclonal antibodies and dyes targeting surface and intracellular markers of differentiation, activation, exhaustion, and cell cycle stages. Samples were run on a CYTOF‐2.ResultsPatterns of naïve [TN] CD4 T cells strongly differed from all other memory subsets central‐memory (CM), transitional‐memory (TM), effector‐memory (EM), and terminally differentiated RA‐expressing (TEMRA) subsets, while stem‐cell memory (SCM) and T follicular‐helper cells (TfH) were close to CM and TM cells with the highest percentages in cell cycle. EM and TEMRA were the most altered by HIV infection, with an increased frequency of activated and cycling cells. Activation markers and coinhibitory receptor expression differed among cell cycle stages, with HLA‐DR fitting better than CD25 or CD38 with cycle, and opposite PD‐1 gradients along differentiation and cell cycle. “Resting” DR‐CD25‐ CD4+ T cells contained similar amounts of cells in G1 than the activated DR ± CD25± ones but three fold lower cells in S‐G2‐M.ConclusionThis broad multiplex mass cytometry analysis demonstrates some subsets of the so‐called “resting” CD25‐DR‐ CD4+ T cells contain noticeable amounts of cells into cycle or expressing coinhibitory receptors, opening new avenues for a redefinition of resting peripheral blood CD4 T cells harboring the HIV reservoirs. © 2016 International Clinical Cytometry Society