bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Claim of Irresistible Desire and the Agranat Doctrine
Authors: Parush Adi 
Published: February 2016

In this article, I will consider several of the general questions raised by the rule that has long guided Israeli courts when faced with a claim of irresistible desire. The claim can be portrayed thus: “Indeed, the defendant perpetrated the act constituting the offence, and did so consciously (as distinct from certain situations of automatism), while aware of the nature of his conduct and knowing that his conduct was unlawful (as opposed to instances of mistake of fact or law). However, although there was no justification for his conduct (as distinct from certain situations of necessity), he has an excuse in that the conduct was the result of a desire he was unable to resist”.This claim may be employed as a defence intended to show that the defendant is not morally culpable for his conduct. But, in this article, I shall consider the claim of irresistible desire as a defence intended to exempt the defendant from criminal responsibility. The two are not necessarily related. Criminal responsibility — as opposed to moral culpability — is a function of law. And what the law establishes in one country may differ from what it establishes in another.
The Double Criminality Rule Revisited
Authors: Williams Sharon A. 
Published: February 2016

Extradition law and process is the complex vehicle for the return by one state of accused or convicted fugitives from the criminal justice of another state. From an international law perspective, it is for the most part, a treaty matter bearing on the rights and duties of states and the emphasis is on inter-state cooperation, reciprocity and mutuality of obligations. However, it is also part of the domestic criminal law process and as the result will be the potential or actual deprivation of the liberty or even the life of the fugitive, if the requesting state retains the death penalty, today extradition is seen as necessarily protecting the human rights of the fugitive.The focus of this article is on the protection given to the fugitive by the double or dual criminahty rule under the extradition law of Canada. Two major issues will be analyzed. Firstly, whether the crime for which the extradition request is made by the foreign state is an extraditable crime meeting the requirement of double criminality and secondly, whether the extradition judge in Canada is mandated to inquire into and seek evidence of the foreign criminal law.
THE LIBYAN CONNECTION: SETTLEMENT, WAR, AND OTHER ENTANGLEMENTS IN NORTHERN CHAD
Authors: SCHEELE JUDITH 
Published: February 2016

AbstractHistorically, connections between southern Libya and northern Chad have always been close, if only due to the fundamental need for connectivity that characterises most Saharan economies. Drawing on so far mostly inaccessible archival records and oral history, this article outlines the implications of this proximity, arguing that it led to intimate entanglements within families and an ongoing confusion of property rights. This in turn resulted in increased rather than diminished hostility during the years of war that opposed the two countries, as people attempted to define uncertain boundaries, and were – and still are – competing for access to similar resources, moral, symbolic, social, and economic.
Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories
Authors: Kishimoto T. , Chawla J. M. , Hagi K. , Zarate C. A. , Kane J. M. , Bauer M. , Correll C. U. 
Published: February 2016

BackgroundKetamine and non-ketamine N-methyl-d-aspartate receptor antagonists (NMDAR antagonists) recently demonstrated antidepressant efficacy for the treatment of refractory depression, but effect sizes, trajectories and possible class effects are unclear.MethodWe searched PubMed/PsycINFO/Web of Science/clinicaltrials.gov until 25 August 2015. Parallel-group or cross-over randomized controlled trials (RCTs) comparing single intravenous infusion of ketamine or a non-ketamine NMDAR antagonist v. placebo/pseudo-placebo in patients with major depressive disorder (MDD) and/or bipolar depression (BD) were included in the analyses. Hedges’ g and risk ratios and their 95% confidence intervals (CIs) were calculated using a random-effects model. The primary outcome was depressive symptom change. Secondary outcomes included response, remission, all-cause discontinuation and adverse effects.ResultsA total of 14 RCTs (nine ketamine studies: n = 234; five non-ketamine NMDAR antagonist studies: n = 354; MDD = 554, BD = 34), lasting 10.0 ± 8.8 days, were meta-analysed. Ketamine reduced depression significantly more than placebo/pseudo-placebo beginning at 40 min, peaking at day 1 (Hedges' g = −1.00, 95% CI −1.28 to −0.73, p < 0.001), and loosing superiority by days 10–12. Non-ketamine NMDAR antagonists were superior to placebo only on days 5–8 (Hedges' g = −0.37, 95% CI −0.66 to −0.09, p = 0.01). Compared with placebo/pseudo-placebo, ketamine led to significantly greater response (40 min to day 7) and remission (80 min to days 3–5). Non-ketamine NMDAR antagonists achieved greater response at day 2 and days 3–5. All-cause discontinuation was similar between ketamine (p = 0.34) or non-ketamine NMDAR antagonists (p = 0.94) and placebo. Although some adverse effects were more common with ketamine/NMDAR antagonists than placebo, these were transient and clinically insignificant.ConclusionsA single infusion of ketamine, but less so of non-ketamine NMDAR antagonists, has ultra-rapid efficacy for MDD and BD, lasting for up to 1 week. Development of easy-to-administer, repeatedly given NMDAR antagonists without risk of brain toxicity is of critical importance.
Mobility and the kinetic politics of migration and development
Authors: Suliman Samid 
Published: February 2016

AbstractThe basic claim of this article is that when the ‘migration-development nexus’ is conceived through a ‘mobilities’ lens, a different account of politics is possible. I refer to this different account of politics as ‘kinetic politics’, to denote that polity formations and political relations are not spatially determined (that is, by processes of boundary formation and relations that travel across these boundaries), but are constituted through movement as people come and go. I argue for a methodological reorientation towards understanding the kinetic politics of development, in order to apprehend the ways in which migrants and migrancy are implicated in the constitution of the polities through which ‘development’ is organised. The recognition of movement as a transversal political relation that cuts across territorial boundaries has implications for the ways in which development is analysed and pursued. I propose that this line of inquiry opens up space to think critically about whether or not formal political membership will remain tethered to problematic territorial and technocratic approaches to ‘sustainable’ development. Might there be space for thinking about migrancy as the basis for rights, and political community as inherently kinetic?
Combining reward shaping and hierarchies for scaling to large multiagent systems
Authors: HolmesParker Chris , Agogino Adrian K. , Tumer Kagan 
Published: February 2016

AbstractCoordinating the actions of agents in multiagent systems presents a challenging problem, especially as the size of the system is increased and predicting the agent interactions becomes difficult. Many approaches to improving coordination within multiagent systems have been developed including organizational structures, shaped rewards, coordination graphs, heuristic methods, and learning automata. However, each of these approaches still have inherent limitations with respect to coordination and scalability. We explore the potential of synergistically combining existing coordination mechanisms such that they offset each others’ limitations. More specifically, we are interested in combining existing coordination mechanisms in order to achieve improved performance, increased scalability, and reduced coordination complexity in large multiagent systems.In this work, we discuss and demonstrate the individual limitations of two well-known coordination mechanisms. We then provide a methodology for combining the two coordination mechanisms to offset their limitations and improve performance over either method individually. In particular, we combine shaped difference rewards and hierarchical organization in the Defect Combination Problem with up to 10 000 sensing agents. We show that combining hierarchical organization with difference rewards can improve both coordination and scalability by decreasing information overhead, structuring agent-to-agent connectivity and control flow, and improving the individual decision-making capabilities of agents. We show that by combining hierarchies and difference rewards, the information overheads and computational requirements of individual agents can be reduced by as much as 99% while simultaneously increasing the overall system performance. Additionally, we demonstrate the robustness of this approach to handling up to 25% agent failures under various conditions.
A reinforcement learning approach to coordinate exploration with limited communication in continuous action games
Authors: Rodríguez Abdel , Vrancx Peter , Grau Ricardo , Nowé Ann 
Published: February 2016

AbstractLearning automata are reinforcement learners belonging to the class of policy iterators. They have already been shown to exhibit nice convergence properties in a wide range of discrete action game settings. Recently, a new formulation for a continuous action reinforcement learning automata (CARLA) was proposed. In this paper, we study the behavior of these CARLA in continuous action games and propose a novel method for coordinated exploration of the joint-action space. Our method allows a team of independent learners, using CARLA, to find the optimal joint action in common interest settings. We first show that independent agents using CARLA will converge to a local optimum of the continuous action game. We then introduce a method for coordinated exploration which allows the team of agents to find the global optimum of the game. We validate our approach in a number of experiments.
To fish or not to fish? Resource degradation and income diversification in Benin
Authors: Stoop Nik , Houssa Romain , Verpoorten Marijke 
Published: February 2016

AbstractThe authors study the impact of natural resource degradation on income diversification in Beninese fishing communities. Using survey data and econometric analysis, they show that fishermen are more likely to diversify their income when the degradation of the fish stock is more severe. However, the level of income diversification that they find is surprisingly low and far from sufficient to relieve the stress on the lakes. The latter relates to low levels of formal education among fishermen and the unregulated use of highly productive, but damaging, fishing gear. These two factors result in a high return to fishing relative to non-fishing activities, even amid degradation.
Weight and skin colour as predictors of vitamin D status: results of an epidemiological investigation using nationally representative data
Authors: Rajan Sonali , Weishaar Tom , Keller Bryan 
Published: February 2016

AbstractObjectiveCurrent US dietary recommendations for vitamin D vary by age. Recent research suggests that body weight and skin colour are also major determinants of vitamin D status. The objective of the present epidemiological investigation was to clarify the role of age as a predictor of vitamin D status, while accounting for body weight and skin colour, among a nationally representative sample.DesignWe calculated the mean serum 25-hydroxyvitamin D levels for the US population by age and weight, as well as by weight and race/ethnicity group. Multiple regression analyses were utilized to evaluate age and weight as predictors of vitamin D status: serum 25-hydroxyvitamin D levels with age alone, age and body weight, and age, body weight and their two-way interaction were modelled for the entire sample and each age subgroup. Graphical data were developed using B-spline non-linear regression.SettingNational Health and Nutrition Examination Survey (31 934 unweighted cases).SubjectsIndividuals aged 1 year and older.ResultsThere were highly significant differences in mean vitamin D status among US residents by weight and skin colour, with those having darker skin colour or higher body weight having worse vitamin D status. Although a significant factor, the impact of age on vitamin D status was notably less than the impact of body weight.ConclusionsVitamin D status varied predominantly by body weight and skin colour. Recommendations by nutritionists for diet and supplementation needs should take this into account if vitamin D-related health disparities are to be meaningfully reduced across the USA.
‘AM I IN ROME, OR IN AULIS?’: JOMMELLI'SCAJO MARIO(1746) AS OPERATICCAPRICCIO
Authors: FORMENT BRUNO 
Published: February 2016

ABSTRACTIn contrast to what its title suggests, Niccolò Jommelli'sCajo Mario(Rome, 1746) has little to do with the consul Caius Marius (157–86 BC). Instead, the opera transposes the myth of Iphigenia in Aulis to the Roman Republic, having Marius, his daughter, her lover and her villainous suitor assume the roles of Agamemnon, Iphigenia, Achilles and Ajax respectively. Thus configured, Jommelli's opera held the stage until 1772, enjoying fifteen revivals with most of the original music intact – a record in the composer's oeuvre. This essay seeks to clarify the reasons for that remarkable success. By juxtaposing Jommelli's score and Gaetano Roccaforte's libretto with a set of six paintings by the contemporary artist Antonio Joli (c1700–1777), it aims to show howCajo Marioshares compositional strategies with a connoisseur's genre in the fine arts: thecapriccio. In keeping with Joli'scapricci, which all deploy the same structural motif,Cajo Marioincorporates a narrative structure through which the ‘parallel universe’ of related works imposes itself on the opera's setting and action, making spectators wonder – as a character does in the course of the opera – whether they are gazing at an event from republican Rome or reliving a legend from ancient Greece.
The (Mis)Representation of African American Music: The Role of the Fiddle
Authors: DJEDJE JACQUELINE COGDELL 
Published: February 2016

AbstractDuring the early twentieth century, research on African American music focused primarily on spirituals and jazz. Investigations on the secular music of blacks living in rural areas were nonexistent except for the work of folklorists researching blues. Researchers and record companies avoided black fiddling because many viewed it not only as a relic of the past, but also a tradition identified with whites. In the second half of the twentieth century, rural-based musical traditions continued to be ignored because researchers tended to be music historians who relied almost exclusively on print or sound materials for analyses. Because rural black musicians who performed secular music rarely had an opportunity to record and few print data were available, sources were lacking. Thus, much of what we know about twentieth-century black secular music is based on styles created and performed by African Americans living in urban areas. And it is these styles that are often represented as the musical creations for all black people, in spite of the fact that other traditions were preferred and performed. This article explores how the (mis)representation of African American music has affected our understanding of black music generally and the development of black fiddling specifically.
Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis
Authors: Zhao X M , Chen Z , Zhao J B , Zhang P P , Pu Y F , Jiang S H , Hou J J , Cui Y M , Jia X L , Zhang S Q 
Published: February 2016

AbstractThe pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis execution. However, the mechanisms that control MLKL activity are not completely understood. Here, we identify the molecular chaperone Hsp90 as a novel MLKL-interacting protein. We show that Hsp90 associates with MLKL and is required for MLKL stability. Moreover, we find that Hsp90 also regulates the stability of the upstream RIP3 kinase. Interference with Hsp90 function with the 17AAG inhibitor destabilizes MLKL and RIP3, resulting in their degradation by the proteasome pathway. Furthermore, we find that Hsp90 is required for TNF-stimulated necrosome assembly. Disruption of Hsp90 function prevents necrosome formation and strongly reduces MLKL phosphorylation and inhibits TNF-induced necroptosis. Consistent with a positive role of Hsp90 in necroptosis, coexpression of Hsp90 increases MLKL oligomerization and plasma membrane translocation and enhances MLKL-mediated necroptosis. Our findings demonstrate that an efficient necrotic response requires a functional Hsp90.
Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis
Authors: Huo J , Ma Y , Liu J-J , Ho Y S , Liu S , Soh L Y , Chen S , Xu S , Han W , Hong A , Lim S C , Lam K-P 
Published: February 2016

AbstractAltered hepatic lipogenesis is associated with metabolic diseases such as obesity and hepatosteatosis. Insulin resistance and compensatory hyperinsulinaemia are key drivers of these metabolic imbalances. Fas apoptosis inhibitory molecule (FAIM), a ubiquitously expressed antiapoptotic protein, functions as a mediator of Akt signalling. Since Akt acts at a nodal point in insulin signalling, we hypothesize that FAIM may be involved in energy metabolism. In the current study, C57BL/6 wild-type (WT) and FAIM-knockout (FAIM-KO) male mice were fed with normal chow diet and body weight changes were monitored. Energy expenditure, substrate utilization and physical activities were analysed using a metabolic cage. Liver, pancreas and adipose tissue were subjected to histological examination. Serum glucose and insulin levels and lipid profiles were determined by biochemical assays. Changes in components of the insulin signalling pathway in FAIM-KO mice were examined by immunoblots. We found that FAIM-KO mice developed spontaneous non-hyperphagic obesity accompanied by hepatosteatosis, adipocyte hypertrophy, dyslipidaemia, hyperglycaemia and hyperinsulinaemia. In FAIM-KO liver, lipogenesis was elevated as indicated by increased fatty acid synthesis and SREBP-1 and SREBP-2 activation. Notably, protein expression of insulin receptor beta was markedly reduced in insulin target organs of FAIM-KO mice. Akt phosphorylation was also lower in FAIM-KO liver and adipose tissue as compared with WT controls. In addition, phosphorylation of insulin receptor substrate-1 and Akt2 in response to insulin treatment in isolated FAIM-KO hepatocytes was also markedly attenuated. Altogether, our data indicate that FAIM is a novel regulator of insulin signalling and plays an essential role in energy homoeostasis. These findings may shed light on the pathogenesis of obesity and hepatosteatosis.
A bacterial filter protects and structures the gut microbiome of an insect
Authors: Lanan Michele Caroline , Rodrigues Pedro Augusto Pos , Agellon Al , Jansma Patricia , Wheeler Diana Esther 
Published: February 2016

Abstract
Associations with symbionts within the gut lumen of hosts are particularly prone to disruption due to the constant influx of ingested food and non-symbiotic microbes, yet we know little about how partner fidelity is maintained. Here we describe for the first time the existence of a gut morphological filter capable of protecting an animal gut microbiome from disruption. The proventriculus, a valve located between the crop and midgut of insects, functions as a micro-pore filter in the Sonoran Desert turtle ant (Cephalotes rohweri), blocking the entry of bacteria and particles ⩾0.2 μm into the midgut and hindgut while allowing passage of dissolved nutrients. Initial establishment of symbiotic gut bacteria occurs within the first few hours after pupation via oral–rectal trophallaxis, before the proventricular filter develops. Cephalotes ants are remarkable for having maintained a consistent core gut microbiome over evolutionary time and this partner fidelity is likely enabled by the proventricular filtering mechanism. In addition, the structure and function of the cephalotine proventriculus offers a new perspective on organismal resistance to pathogenic microbes, structuring of gut microbial communities, and development and maintenance of host–microbe fidelity both during the animal life cycle and over evolutionary time.
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology
Authors: Hungate Eric A. , Vora Sapana R. , Gamazon Eric R. , Moriyama Takaya , Best Timothy , Hulur Imge , Lee Younghee , Evans Tiffany-Jane , Ellinghaus Eva , Stanulla Martin , Rudant Jéremie , Orsi Laurent , Clavel Jacqueline , Milne Elizabeth , Scott Rodney J. , Pui Ching-Hon , Cox Nancy J. , Loh Mignon L. , Yang Jun J. , Skol Andrew D. , Onel Kenan 
Published: February 2016

AbstractPaediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common cancer of childhood, yet little is known about BCP-ALL predisposition. In this study, in 2,187 cases of European ancestry and 5,543 controls, we discover and replicate a locus indexed by rs77728904 at 9p21.3 associated with BCP-ALL susceptibility (Pcombined=3.32 × 10−15, OR=1.72) and independent from rs3731217, the previously reported ALL-associated variant in this region. Of correlated SNPs tagged by this locus, only rs662463 is significant in African Americans, suggesting it is a plausible causative variant. Functional analysis shows that rs662463 is a cis-eQTL for CDKN2B, with the risk allele associated with lower expression, and suggests that rs662463 influences BCP-ALL risk by regulating CDKN2B expression through CEBPB signalling. Functional analysis of rs3731217 suggests it is associated with BCP-ALL by acting within a splicing regulatory element determining CDKN2A exon 3 usage (P=0.01). These findings provide new insights into the critical role of the CDKN2 locus in BCP-ALL aetiology.
PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
Authors: Shinde Swapnil Rohidas , Maddika Subbareddy 
Published: February 2016

AbstractTumour suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a lipid phosphatase that negatively regulates growth factor-induced survival signalling. Here, we demonstrate that PTEN attenuates epidermal growth factor receptor (EGFR) signalling by promoting late endosome maturation by virtue of its protein phosphatase activity. Loss of PTEN impairs the transition of ligand-bound EGFR from early to late endosomes. We unveil Rab7, a critical GTPase for endosome maturation, as a functional PTEN interacting partner. PTEN dephosphorylates Rab7 on two conserved residues S72 and Y183, which are necessary for GDP dissociation inhibitor (GDI)-dependent recruitment of Rab7 on to late endosomes and subsequent maturation. Thus, our findings reveal PTEN-dependent endosome maturation through phosphoregulation of Rab7 as an important route of controlling EGFR signalling.