bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Neuromuscular Electrical Stimulation on Physiologic and Functional Measurements in Patients With Heart Failure
Authors: Gomes Neto Mansueto , Oliveira Felipe Assis , Reis Helena França Correia dos , de Sousa Rodrigues- Erenaldo , Bittencourt Hugo Souza , Carvalho Vitor Oliveira 
Published: January 2016

BACKGROUND:
Neuromuscular electrical stimulation (NMES) is potentially attractive as a method of training in heart failure (HF) and could be performed in patients unable to participate in standard exercise training.

PURPOSE:
To examine the effects of NMES on physiologic and functional measurements in patients with HF.

METHODS:
MEDLINE, Cochrane, EMBASE, Scielo, and PEDro were searched from the earliest date available to July 2014. Two independent reviewers screened the titles and abstracts and selected randomized controlled trials, examining the effects of NMES versus exercise and/or of NMES versus control on physiologic and functional measurements in patients with HF. Two independent reviewers screened the randomized controlled trials. The PEDro score was used to evaluate methodological quality. Weighted mean differences and 95% CI were calculated.

RESULTS:
Thirteen studies met the study criteria. Neuromuscular electrical stimulation resulted in improvement in peak oxygen uptake (

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2) (4.86 mL·kg−1 ·min−1; 95% CI, 2.81-6.91), 6-minute walk test (6MWT) distance (63.54 m; 95% CI, 35.81-91.27), muscle strength (30.74 N; 95% CI, 3.67-57.81), flow-mediated dilatation (2.67%; 95% CI, 0.86-4.49), depressive symptoms (−3.86; 95% CI, −6.46 to −1.25), and global quality of life (0.89; 95% CI, 0.55-1.24). Nonsignificant differences in (

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2) peak, 6MWT, and quality of life were found for participants in the exercise group compared with NMES.

CONCLUSIONS:
Neuromuscular electrical stimulation improved peak

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2, 6MWT distance, quality of life, muscle strength, endothelial function, and depressive symptoms in patients with HF and could be considered for inclusion in cardiac rehabilitation for selected patients.
Topical Coenzyme Q10 Eye Drops as an Adjuvant Treatment in Challenging Refractory Corneal Ulcers: A Case Series and Literature Review
Authors: Gumus Koray 
Published: January 2016

Purpose:
The management of nonhealing corneal ulcers, particularly in patients with neurotrophic corneas, remains a challenging problem today. Some patients may fail to respond to conventional therapy, making new alternative agents necessary to treat these resistant cases. In this article, we aim to present six challenging cases of refractory corneal ulcers that revealed healing response to the adjuvant treatment with coenzyme Q10 (CoQ10) eye drops and to review the literature examining of new therapeutic agents.

Methods:
Our study was designed as a descriptive case series demonstrating the use of novel coenzyme Q10 eye drops in refractory corneal ulcers. In our case series, CoQ10 eye drops were added to the existing therapies as an adjuvant agent in six cases: three cases with neurotrophic corneal ulcers, two cases with postinfectious corneal ulcers (one unknown etiology+one Acanthamoeba keratitis), and 1 case with Stevens–Johnson syndrome. All cases were monitored regularly and corneal images were taken at all visits.

Results:
All nonhealing corneas with conventional therapy revealed recovery after the addition of CoQ10 eye drops. Except for two cases that responded to the CoQ10 eye drops more rapidly (within 1 to 2 weeks), complete corneal healing was observed in four cases between weeks 4 and 8. No adverse events were reported in these cases throughout the follow-up period.

Conclusion:
Coenzyme Q10 eye drops can be considered as an important adjuvant therapeutic agent promoting corneal epithelial wound healing in challenging cases.
Graves Lower Eyelid Retraction
Authors: Ribeiro Sara Filipa Teixeira , Shekhovtsova Maria , Duarte Ana Filipa , Velasco Cruz Antonio Augusto 
Published: January 2016

Purpose:
Graves lower eyelid retraction (GLLR) is a common and controversial sign of Graves orbitopathy. The authors reviewed the mechanisms and surgical techniques currently used to correct this Graves orbitopathy-related eyelid malposition.

Methods:
A literature search was performed on the MEDLINE database using the keywords “lower eyelid retraction,” “Graves orbitopathy,” “thyroid ophthalmopathy,” “thyroid eye disease,” “spacers,” and “eyelid surgery.” Only articles in English were included. The level of evidence of publications regarding surgical correction of GLLR was evaluated and graded from I to IV, using a rating system adapted from a validated scientific evidence classification method.

Results:
The mechanisms responsible for GLLR are not fully understood and no subtypes of GLLR have been distinguished. The surgical literature of GLLR encompasses mainly descriptions of surgical techniques without objective measurements of the results, and uncontrolled studies. Only 1 randomized controlled trial was identified. To lengthen the lower retractors, a large variety of different materials have been used as spacers.

Conclusions:
The scientific literature on GLLR is vast, however controlled and randomized studies comparing different surgical techniques are lacking. At the present moment it is not clear if bioengineered materials are superior to conventional autogeneous tissue as lower eyelid spacers. The effects of GLLR on lower eyelid movements and contour have not been studied.
Clinician Attitudes Toward Adoption of Pediatric Emergency Telemedicine in Rural Hospitals
Authors: Ray Kristin N. , Felmet Kathryn A. , Hamilton Melinda F. , Kuza Courtney C. , Saladino Richard A. , Schultz Brian R. , Watson R. Scott , Kahn Jeremy M. 
Published: January 2016

Objective
Although there is growing evidence regarding the utility of telemedicine in providing care for acutely ill children in underserved settings, adoption of pediatric emergency telemedicine remains limited, and little data exist to inform implementation efforts. Among clinician stakeholders, we examined attitudes regarding pediatric emergency telemedicine, including barriers to adoption in rural settings and potential strategies to overcome these barriers.

Methods
Using a sequential mixed-methods approach, we first performed semistructured interviews with clinician stakeholders using thematic content analysis to generate a conceptual model for pediatric emergency telemedicine adoption. Based on this model, we then developed and fielded a survey to further examine attitudes regarding barriers to adoption and strategies to improve adoption.

Results
Factors influencing adoption of pediatric emergency telemedicine were identified and categorized into 3 domains: contextual factors (such as regional geography, hospital culture, and individual experience), perceived usefulness of pediatric emergency telemedicine, and perceived ease of use of pediatric emergency telemedicine. Within the domains of perceived usefulness and perceived ease of use, belief in the relative advantage of telemedicine was the most pronounced difference between telemedicine proponents and nonproponents. Strategies identified to improve adoption of telemedicine included patient-specific education, clinical protocols for use, decreasing response times, and simplifying the technology.

Conclusions
More effective adoption of pediatric emergency telemedicine among clinicians will require addressing perceived usefulness and perceived ease of use in the context of local factors. Future studies should examine the impact of specific identified strategies on adoption of pediatric emergency telemedicine and patient outcomes in rural settings.
Pediatric Necrotizing Pneumonia
Authors: Ramgopal Sriram , Ivan Yaron , Medsinge Avinash , Saladino Richard A. 
Published: January 2016

Abstract
Necrotizing pneumonias occur infrequently in children but may be associated with significant morbidity. If not adequately treated, necrotizing pneumonia may lead to complications including bronchopleural fistula, empyema, respiratory failure, and septic shock. Staphylococcus aureus is the most commonly implicated agent, followed by Streptococcus pneumoniae. Antimicrobial treatment is the cornerstone of management, although surgical drainage may be required in some cases. We present the case of a 14-month-old child with fever and cough that persisted despite treatment with typical first-line oral antimicrobial therapy. An initial plain radiograph of the chest demonstrated lobar pneumonia. Ultimately, computed tomography of the chest revealed a cavitary lesion in the left upper lobe of the lung. We review the literature and describe the clinical presentation, diagnosis, microbiological etiology, and management of necrotizing pneumonia in children.
Comparison of the GlideScope Cobalt® and Storz DCI® Video Laryngoscopes in Children Younger Than 2 Years of Age During Manual In-Line Stabilization
Authors: Vadi Marissa G. , Roddy Katie J. , Ghazal Elizabeth A. , Um Michael , Neiheisel Andrew J. , Applegate Richard L. 
Published: January 2016

Objectives
Video laryngoscopy facilitates tracheal intubation during manual in-line stabilization in adults, but it is not clear whether these findings translate to children. We compared trainee intubation times obtained using the GlideScope Cobalt® and Storz DCI® video laryngoscopes versus direct laryngoscopy in young children with immobilized cervical spines.

Methods
Ninety-three children younger than 2 years underwent laryngoscopy with manual in-line stabilization using direct laryngoscopy, GlideScope Cobalt® video laryngoscopy, or Storz DCI® video laryngoscopy. Laryngoscopists were anesthesiology trainees in postgraduate training year of 3 or more. Total time to successful intubation (TTSI), best glottic view, and maximum degrees of neck deviation were recorded. An intubation time difference longer than 10 seconds was defined as clinically significant.

Results
Data are reported as median; 95% confidence interval. The TTSI was similar among groups although Storz times were longer (median, 33.3 seconds; 95% confidence interval, 26.2–43.3 seconds) when compared to direct laryngoscopy (median, 23.3 seconds; 95% confidence interval, 20.7–26.5 seconds; P = 0.02). Obtaining a grade 1 Cormack-Lehane glottic view was less likely with direct laryngoscopy (P = 0.002). Maximum degrees of neck deviation were: Storz (median, 2.0; 95% confidence interval, 1.2–2.8), GlideScope (median, 2.0; 95% confidence interval, 1.4–2.6), and direct laryngoscopy (median, 1.9; 95% confidence interval, 1.2–2.1; P = 0.48).

Conclusions
Trainees were able to safely perform tracheal intubation in children younger than 2 years using any of the studied laryngoscopes, although Storz use resulted in a longer TTSI when compared to direct laryngoscopy. Video laryngoscopy may enhance best Cormack-Lehane glottic view during manual in-line cervical spine immobilization, but additional technical skills are needed to successfully complete tracheal intubation.
Relation of Medical History to the Pediatric Out-of-Hospital Cardiac Arrest Managed by Emergency Medical Services
Authors: Heinonen Kari , Lehtimäki Nea , Suominen Pertti , Kuisma Markku , Harve Heini 
Published: January 2016

Objective
The aim of this study was to examine the medical history of the pediatric out-of-hospital cardiac arrest (OHCA) patients to determine preexisting conditions that may relate to a later OHCA.

Methods
The study was a retrospective population-based cohort study in Helsinki (population 595,000) served by a single emergency medical service (EMS) system. All OHCA patients aged between 0 and 17 met by the local EMS from 2002 to 2011 were included. Medical records of the Helsinki University Hospital and its clinics were examined to find preexisting medical or surgical conditions.

Results
Forty-three patients experienced an EMS-treated OHCA. The annual incidence of an EMS-treated OHCA was 4.4 per 100,000 population younger than the age of 18 years. The mean age of patients was 7.9 years, largest age groups being younger than 1 year (30.2%) and 17 years (23.2%). The leading cause of OHCA was trauma (30.2%) followed by sudden infant death syndrome (18.6%) and cardiac reasons (14.0%). Nine patients (20.9%) survived to hospital, and 5 (11.6%) were discharged alive. Of the 43 patients, 28 (65.1%) had prior medical records in Helsinki University Hospital considering suspected or diagnosed chronic or otherwise significant conditions. The most common conditions were perinatal adaptation abnormalities (20.9%), psychiatric treatment (16.3%), and epilepsy (13.9%). Five patients had previous cardiac conditions. Trauma as a cause of OHCA was frequently represented among patients with prior psychiatric diagnosis or treatment. Among 17-year-old OHCA patients, 5 of 10 had psychiatric records.

Conclusions
Majority of the patients had prior medical records. Psychiatric disorders were strongly presented.
Three-Dimensional Computed Tomographic Angiography Study of the Interperforator Flow of the Lower Leg
Authors: Sur Yoo Joon , Morsy Mohamed , Mohan Anita T. , Zhu Lin , Michalak Gregory J. , Lachman Nirusha , Laungani Alexis T. , van Alphen Nick , Saint-Cyr Michel 
Published: January 2016

Background:
The area perfused by a single perforator depends on its perforasome and its unique interperforator flow pattern. The purpose of this study was to clarify the interperforator flow patterns of the peroneal and posterior tibial artery perforators using three-dimensional computed tomographic angiography.

Methods:
Thirteen whole-leg skin flaps were harvested in the subfascial plane from fresh cadavers. Peroneal, posterior tibial, anterior tibial, and sural artery perforators with a diameter greater than 0.5 mm were documented. Three-dimensional computed tomographic angiography with an injection of iodinated contrast medium into the peroneal or posterior tibial artery perforator was used to investigate the percentages of the area and the perforators that were perfused.

Results:
The mean percentage of the total area perfused was as follows: peroneal artery perforator, 42.0 percent; posterior tibial artery perforator, 38.0 percent (p = 0.084). The mean percentage of the total perforators perfused was as follows: peroneal artery perforator, 55.0 percent; posterior tibial artery perforator, 44.2 percent (p = 0.004). Although the mean percentages of same-source artery perforators perfused by a peroneal artery perforator (73.6 percent) and by a posterior tibial artery perforator (77.2 percent) did not differ (p = 0.513), the mean percentages of other-source artery perforators perfused by a peroneal artery perforator (49.9 percent) and by a posterior tibial artery perforator (32.3 percent) were significantly different (p < 0.001).

Conclusions:
This study demonstrated that a single peroneal or posterior tibial artery perforator perfused approximately 40 percent of the whole leg surface and that peroneal and posterior tibial artery perforators had different interperforator flow patterns. The results of this study may improve preoperative planning for pedicled perforator flap surgery.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, V.
The Frankish model of disability psychotherapy in practice: an integrative model
Authors: McInnis Erica Elaine 
Published: January 2016

Purpose
– The purpose of this paper is to focus on the theory and practice of disability psychotherapy (DP) using the integrative Frankish model (2013a). This draws on the model’s use with a 28-year-old male with a mild intellectual disability (ID) who presented with a range of emotional and behavioural problems.

Design/methodology/approach
– A case study reporting on the practice of DP of psychodynamic orientation.

Findings
– Adaptations useful in providing DP with people with IDs and the type of issues which arise are reported.

Research limitations/implications
– DP is possible and beneficial in community settings. Limitations of a single case study include generalisability of findings.

Originality/value
– Existing papers focus on the model (Frankish, 2013a), development of the emotional development measuring tool (Frankish, 2013b) and contextual issues (Frankish, 2013c). This case study provides novel information on the practice of DP, and analysis of manifestations of white supremacy (Ani, 1994) in psychotherapy with people with IDs.
Update on psychopharmacology for autism spectrum disorders
Authors: Bertelli Marco O. , Rossi Michele , Keller Roberto , Lassi Stefano 
Published: January 2016

Purpose
– The management of individuals with autism spectrum disorders (ASDs) requires a multimodal approach of behavioural, educational and pharmacological treatments. At present, there are no available drugs to treat the core symptoms of ASDs and therefore a wide range of psychotropic medications are used in the management of problems behaviours, co-occurring psychiatric disorders and other associated features. The purpose of this paper is to map the literature on pharmacological treatment in persons with ASD in order to identify those most commonly used, choice criteria, and safety.

Design/methodology/approach
– A systematic mapping of the recent literature was undertaken on the basis of the following questions: What are the most frequently used psychoactive compounds in ASD? What are the criteria guiding the choice of a specific compound? How effective and safe is every psychoactive drug used in ASD? The literature search was conducted through search engines available on Medline, Medmatrix, NHS Evidence, Web of Science and the Cochrane Library.

Findings
– Many psychotropic medications have been studied in ASDs, but few have strong evidence to support their use. Most commonly prescribed medications, in order of frequency, are antipsychotics, antidepressants, anticonvulsants and stimulants, many of them without definitive studies guiding their usage. Recent animal studies can be useful models for understanding the common pathogenic pathways leading to ASDs, and have the potential to offer new biologically focused treatment options.

Originality/value
– This is a practice review paper applying recent evidence from the literature.
Business process rearrangement and renaming
Authors: Khosravi Ali 
Published: January 2016

Purpose
– Process orientation, which involves managing organizations based on horizontal end-to-end processes, has been shown to increase the quality of products/services, decrease costs, and make business functions faster and more reliable. However, current process orientation methods are radical and destructive, leading to failure in most cases. The purpose of this paper is to present a non-destructive method of implementation.

Design/methodology/approach
– Supporting by literature review and two case studies, this paper presents a new process orientation methodology named as Business Process Rearrangement and Renaming (BPR2).

Findings
– The existing process management methodologies mostly aim to provide a comprehensive view on all of the main activities involved in process management and strategic alignment, with insignificant focus on mitigating the risk of failure in their redesign stage. In contrast, every step in the methodology presented in this paper, including the design phase, aim to reduce the risk of failure.

Practical implications
– Name is the most communicated characteristic of a department; however, this most communicated characteristic of the departments has always been the most neglected characteristic as well. For the first time in the literature, this paper provides a description on how to use the power of departmental names to promote the main customer values expected from each department.

Originality/value
– Added to a detailed guideline on the new process design and process names, this paper presents a new marketing mix model with a process-oriented delegation of authority view, which may be of interest to the marketing researchers and practitioners.
BPM for supporting customer relationship and profit decision
Authors: Lau Henry , Nakandala Dilupa , Samaranayake Premaratne , Shum Paul K. 
Published: January 2016

Purpose
– As a response to increasing global market competition, companies in various industries tend to identify and manage customer relationship to increase profit performance. Companies commit more resources to identify their VIP customers and retain them by all means. The purpose of this paper is to develop a customer relationship management (CRM) business process management (BPM) model to identify airline customers with different degree of relationship and profit potential, and select the highly profitable customers for developing retention strategy and processes, and convert the less profitable into profitable corporate accounts.

Design/methodology/approach
– This study innovatively apply the well-known techniques including CRM and relationship marketing models, fuzzy analytic hierarchy process (FAHP), and technique for order preference by similarity to ideal solution (TOPSIS) in the BPM research. This novel approach analyzes longer term customer profit and value potential, and prioritizes corporate accounts as the basis for setting appropriate customer service levels and improving the CRM process. This hybrid model is able to capitalize on the benefits of these methods and offset their deficiencies. Most importantly, it can be customized to various industries without complex modification.

Findings
– This study uses data of an airline company to validate feasibility of the proposed CRM BPM model. The results indicate that this model is able to classify the customers based on various criteria and sub-criteria, thus allowing companies to introduce appropriate service levels to deal with different categories of customers, and improve CRM process so as to maximize customer profit and value potential.

Practical implications
– This CRM BPM model and analysis provide managers extensive customer knowledge, more analytical and fact-based decision-making support, and a stronger focus on return on investment in sales and marketing. Knowing the profit and value potential generated by individual corporate customer makes it easier to establish the link between the CRM and the profit outcome. This model also benefits the organization and its stakeholders by allocating more resources to the targeted customer relationships that are profitable or valuable, and makes marketing more accountable in its marketing programs.

Originality/value
– This study makes the first move to innovatively apply the well-known techniques including CRM and relationship marketing models, FAHP, and TOPSIS in the BPM research.