bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of advanced neuroimaging, fluid biomarkers and genetic testing in the assessment of sport-related concussion: a systematic review
Authors: McCrea Michael , Meier Timothy , Huber Daniel , Ptito Alain , Bigler Erin , Debert Chantel T , Manley Geoff , Menon David , Chen Jen-Kai , Wall Rachel , Schneider Kathryn J , McAllister Thomas 
Published: April 2017

ObjectiveTo conduct a systematic review of published literature on advanced neuroimaging, fluid biomarkers and genetic testing in the assessment of sport-related concussion (SRC).Data sourcesComputerised searches of Medline, PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, Scopus and Cochrane Library from 1 January 2000 to 31 December 2016 were done. There were 3222 articles identified.Study selectionIn addition to medical subject heading terms, a study was included if (1) published in English, (2) represented original research, (3) involved human research, (4) pertained to SRC and (5) involved data from neuroimaging, fluid biomarkers or genetic testing collected within 6 months of injury. Ninety-eight studies qualified for review (76 neuroimaging, 16 biomarkers and 6 genetic testing).Data extractionSeparate reviews were conducted for neuroimaging, biomarkers and genetic testing. A standardised data extraction tool was used to document study design, population, tests employed and key findings. Reviewers used a modified quality assessment of studies of diagnostic accuracy studies (QUADAS-2) tool to rate the risk of bias, and a modified Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to rate the overall level of evidence for each search.Data synthesisResults from the three respective reviews are compiled in separate tables and an interpretive summary of the findings is provided.ConclusionsAdvanced neuroimaging, fluid biomarkers and genetic testing are important research tools, but require further validation to determine their ultimate clinical utility in the evaluation of SRC. Future research efforts should address current gaps that limit clinical translation. Ultimately, research on neurobiological and genetic aspects of SRC is predicted to have major translational significance to evidence-based approaches to clinical management of SRC, much like applied clinical research has had over the past 20 years.
What is the difference between comprehensive and selective primary health care? Evidence from a five-year longitudinal realist case study in South Australia
Authors: Baum Fran , Freeman Toby , Lawless Angela , Labonte Ronald , Sanders David 
Published: April 2017

BackgroundSince the WHO’s Alma Ata Declaration on Primary Health Care (PHC) there has been debate about the advisability of adopting comprehensive or selective PHC. Proponents of the latter argue that a more selective approach will enable interim gains while proponents of a comprehensive approach argue that it is needed to address the underlying causes of ill health and improve health outcomes sustainably.MethodsThis research is based on four case studies of government-funded and run PHC services in Adelaide, South Australia. Program logic models were constructed from interviews and workshops. The initial model represented relatively comprehensive service provision in 2010. Subsequent interviews in 2013 permitted the construction of a selective PHC program logic model following a series of restructuring service changes.ResultsComparison of the PHC service program logic models before and after restructuring illustrates the changes to the operating context, underlying mechanisms, service qualities, activities, activity outcomes and anticipated community health outcomes. The PHC services moved from focusing on a range of community, group and individual clinical activities to a focus on the management of people with chronic disease. Under the more comprehensive model, activities were along a continuum of promotive, preventive, rehabilitative and curative. Under the selective model, the focus moved to rehabilitative and curative with very little other activities.ConclusionThe study demonstrates the difference between selective and comprehensive approaches to PHC in a rich country setting and is useful in informing debates on PHC especially in the context of the Sustainable Development Goals.
Essential components of integrated care for youth with mental health and addiction needs: protocol for a scoping review
Authors: Settipani Cara A , Cleverley Kristin , Hawke Lisa D , Rice Maureen , Henderson Joanna L 
Published: April 2017

IntroductionEfforts to move towards integrated care have been met with increased interest and enthusiasm in recent years given the potential to improve care and population health while containing costs. However, there is a need to better understand community-based integrated care approaches for youth with mental health and/or addiction concerns to guide future implementation efforts and develop a set of standards for key components. The objectives of this scoping review are to: (1) identify the populations, settings, service providers, interventions, infrastructure and care coordination methods that have been included in integrated care for youth with mental health and/or addiction needs and (2) identify constructs that have been measured and evaluated (eg, outcomes, engagement) in the context of youth integrated care.Methods and analysisSeven electronic databases and several grey literature sources will be searched for material from 2001 to 2016. Inclusion criteria will be broad with respect to type of work, as we will include all types of research studies as well as non-research studies that provide information relevant to characteristics and constructs measured in the context of integrated care for youth mental health. Titles and abstracts will be independently screened for eligibility by two raters using inclusion criteria. Full-text articles will then be accessed and independently screened for inclusion. A formal data extraction method will be employed, enabling synthesis of results in quantitative and qualitative formats.Ethics and disseminationResults will be widely disseminated to various stakeholders to inform implementation and research efforts. Findings will also launch a Delphi method study leading to the development of an assessment tool for youth mental health services integration. This review does not require ethics approval.
SWITCH: Al Wakra Hospital Journey to 90% Hand Hygiene Practice Compliance, 2011 – 2015
Authors: Visan Feah Altura - , Zakaria Almunzer , Castro Jenalyn , Alhasanat Omar , Ismail Khalil Al , Ansari Naser Al , Hamed Manal 
Published: April 2017

Hand Hygiene is the cheapest and simplest way to prevent the spread of infection, however international compliance is below than 40% (WHO, 2009). In the experience of Al Wakra Hospital, the improvement in hand hygiene compliance highlighted not just interventions towards training and education but also behavioral motivation and physical allocations of hand hygiene appliances and equipment.Through motivating the behavioral, emotional, physical and intellectual dimensions of the different healthcare worker professions, hand hygiene compliance has increased from 60.78% in 2011 to 94.14% by the end of December 2015. It took 25 months of continuous and collaborative work with different healthcare workers to reach the 90% hand hygiene target.“Together, we have reached our goals and together we fight against infections! Because we always strive for excellence in everything we do – that is our vision here in Al Wakra Hospital.”
Care standards for non-alcoholic fatty liver disease in the United Kingdom 2016: a cross-sectional survey
Authors: Sheridan David A , Aithal Guru , Alazawi William , Allison Michael , Anstee Quentin , Cobbold Jeremy , Khan Shahid , Fowell Andrew , McPherson Stuart , Newsome Philip N , Oben Jude , Tomlinson Jeremy , Tsochatzis Emmanouil 
Published: April 2017

ObjectiveGuidelines for the assessment of non-alcoholic fatty liver disease (NAFLD) have been published in 2016 by National Institute for Health and Care Excellence and European Associations for the study of the Liver–European Association for the study of Diabetes–European Association for the study of Obesity. Prior to publication of these guidelines, we performed a cross-sectional survey of gastroenterologists and hepatologists regarding NAFLD diagnosis and management.DesignAn online survey was circulated to members of British Association for the Study of the Liver and British Society of Gastroenterology between February 2016 and May 2016.Results175 gastroenterologists/hepatologists responded, 116 completing the survey, representing 84 UK centres. 22% had local NAFLD guidelines. 45% received >300 referrals per year from primary care for investigation of abnormal liver function tests (LFTs). Clinical assessment tended to be performed in secondary rather than primary care including body mass index (82% vs 26%) and non-invasive liver screen (86% vs 32%) and ultrasound (81% vs 37%).Widely used tools for non-invasive fibrosis risk stratification were aspartate transaminase (AST)/alanine transaminase (ALT) ratio (53%), Fibroscan (50%) and NAFLD fibrosis score (41%). 78% considered liver biopsy in selected cases. 50% recommended 10% weight loss target as first-line treatment. Delivery of lifestyle interventions was mostly handed back to primary care (56%). A minority have direct access to community weight management services (22%).Follow-up was favoured by F3/4 fibrosis (72.9%), and high-risk non-invasive fibrosis tests (51%). Discharge was favoured by simple steatosis at biopsy (30%), and low-risk non-invasive scores (25%).ConclusionsThe survey highlights areas for improvement of service provision for NAFLD assessment including improved recognition of non-alcoholic steatohepatitis in people with type 2 diabetes, streamlining abnormal LFT referral pathways, defining non-invasive liver fibrosis assessment tools, use of liver biopsy, managing metabolic syndrome features and improved access to lifestyle interventions.
Use of non-steroidal anti-inflammatory drugs in US adults: changes over time and by demographic
Authors: Davis Jennifer S , Lee Hwa Young , Kim Jihye , Advani Shailesh M , Peng Ho-Lan , Banfield Emilyn , Hawk Ernest T , Chang Shine , Frazier-Wood Alexis C 
Published: April 2017

ObjectiveAspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) are preventive against cardiovascular disease (CVD) and several cancer types, but long-term use has been associated with significant health risks, resulting in conflicting recommendations on NSAID use for prevention of CVD and cancer. Previous research indicates that aspirin use increases with age and CVD risk factors and that a large percentage of the US population regularly use analgesics, including NSAIDs, but there has not been a recent, in-depth assessment of NSAID use prevalence, changes in use over time or predictors of NSAID use in the USA.MethodsWe used the cross-sectional, National Health And Nutrition Examination Survey (NHANES) from 1988 to 1994 and three continuous cycles (1999–2004) to assess regular NSAID use prevalence, changes over time and predictors of regular NSAID use.ResultsOverall, regular NSAID use increased over time and varied by demographic features. Participants over 60 years of age, women, participants with high body mass index, increased waist circumference or heart disease were significantly more likely to be regular NSAID users. By contrast, non-Hispanic African American and Mexican American participants were significantly less likely to regularly use NSAIDs.ConclusionsThis study uses a nationally representative data set (NHANES) to provide an exploration of regular NSAID use patterns over time, highlighting several demographic, lifestyle and clinical conditions associated with regular NSAID use. Understanding who is likely to regularly use NSAIDs enables more targeted messaging both for increasing the preventive benefits and for limiting the toxicities associated with regular use of NSAIDs.
A literature review of cost-effectiveness of intravenous recombinant tissue plasminogen activator for treating acute ischaemic stroke
Authors: Joo Heesoo , Wang Guijing , George Mary G 
Published: April 2017

BackgroundIntravenous recombinant tissue plasminogen activator (IV rtPA) is recommended treatment for patients with acute ischaemic stroke, but the cost-effectiveness of IV rtPA within different time windows after the onset of acute ischaemic stroke is not well reviewed.AimsTo conduct a literature review of the cost-effectiveness studies about IV rtPA by treatment times.Summary of reviewA literature search was conducted using MEDLINE, EMBASE, CINAHL and Cochrane Library, with the keywords acute ischemic stroke, tissue plasminogen activator, cost, economic benefit, saving and incremental cost-effectiveness analysis. The review is limited to original research articles published during 1995–2016 in English-language peer-reviewed journals. We found 16 studies meeting our criteria for this review. Nine of them were cost-effectiveness studies of IV rtPA treatment within 0–3 hours after stroke onset, 2 studies within 3–4.5 hours, 3 studies within 0–4.5 hours and 2 studies within 0–6 hours. IV rtPA is a cost-saving or a cost-effectiveness strategy from most of the study results. Only one study showed incremental cost-effectiveness ratio of IV rtPA within 1 year was marginally above US$50 000 per quality-adjusted life year threshold. IV rtPA within 0–3 hours after stroke led to cost savings for lifetime or 30 years and IV rtPA within 3–4.5 hours after stroke increased costs but still was cost-effective.ConclusionsThe literature generally showed that IV rtPA was a dominant or a cost-effective strategy compared with traditional treatment for patients with acute ischaemic stroke without IV rtPA. The findings from the literature lacked generalisability because of limited data and various assumptions.
Unravelling an allochthonous, subaqueously deposited volcanic–epiclastic to subaerial andesitic lava assemblage in Hong Kong: age, stratigraphy and provenance studies of the Middle Jurassic Tuen Mun Formation
Authors: Sewell R. J. , So K. W. F. , Tang D. L. K. , Carter A. 
Published: April 2017

The Middle Jurassic Tuen Mun Formation, Hong Kong, is a fault-bounded block of rare andesitic and related rocks that preserve a snapshot of the developing SE China continental arc system during the late Mesozoic. The forearc depositional setting is considered to have been dominated by an emergent andesitic volcanic massif, which shows a transition to a fluvial-dominated volcanic plain, and then to an offshore marine environment. The youngest laser ablation inductively coupled plasma mass spectrometry U–Pb detrital zircon ages obtained from the three packages define a coherent group (
n
= 396; MSWD = 1.8) suggesting a maximum depositional age of 169.5 ± 0.3 Ma. The dominance of large euhedral and concentrically zoned zircons reflects a common volcanic provenance. Hf isotope data (
ε
Hf
(
t
) = 0 to −11) on the youngest representative zircon grains imply derivation of magmas from dominantly recycled crustal sources. The detrital zircon age signatures and Hf isotope data show no indication of magmatic interaction with adjacent late Palaeozoic and Early to Middle Jurassic sedimentary rocks, or Middle Jurassic to Early Cretaceous magmatic rocks of Hong Kong. On the basis of the structural, zircon age and isotope data, the Tuen Mun Formation is interpreted to be an allochthonous block, emplaced in the Hong Kong region during the late Middle Jurassic.

Supplementary material:
A full dataset of U–Pb dating and Hf isotope analysis of detrital zircons, stratigraphic drillhole logs and a description of the terminology used in this paper are available at
https://doi.org/10.6084/m9.figshare.c.3736972
Geologically driven 3D modelling of physical rock properties in support of interpreting the seismic response of the Lalor volcanogenic massive sulphide deposit, Snow Lake, Manitoba, Canada
Authors: Schetselaar Ernst , Bellefleur Gilles , Craven James , Roots Eric , Cheraghi Saeid , Shamsipour Pejman , Caté Antoine , Mercier-Langevin Patrick , El Goumi Najib , Enkin Randolph , Salisbury Matthew 
Published: April 2017

Abstract
3D lithofacies and physical rock property models were generated to interpret 3D seismic data acquired over the Lalor volcanogenic massive sulphide deposit, Manitoba, Canada. The lithofacies model revealed that strong seismic reflectivity is associated with ore–host rock and mafic–felsic lithofacies contacts, including their hydrothermally altered equivalents. Different physical rock property models were subjected to 3D seismic forward modelling using the SOFI3D finite difference code. Seismic synthetics from discrete and interpolated models in which kriging of P-wave velocity and density was conditioned by curvilinear grids conformable to the 3D-modelled geological structure showed a much better match to the seismic data in comparison with those generated by kriging in Cartesian space. Synthetics from these curvilinear grid models corroborate the origin of seismic reflectors, as qualitatively inferred from the lithofacies model. Seismic synthetics generated from physical rock property models in which physical rock properties were augmented by densely sampled secondary variables, such as FeO percentage, enhanced lateral continuity of seismic reflectivity, although these co-kriged petrophysical models were not more accurate than their kriged equivalents. The physical rock property modelling methodology was also useful for testing the utility of passive interferometric seismic surveys, as this highlighted the limitations of the discrete physical rock property model.
Quantitative cardiac phosphoproteomics profiling during ischemia-reperfusion in an immature swine model
Authors: Ledee Dolena , Kang Min A. , Kajimoto Masaki , Purvine Samuel , Brewer Heather , Pasa-Tolic Ljiljana , Portman Michael A. 
Published: April 2017

Ischemia-reperfusion (I/R) results in altered metabolic and molecular responses, and phosphorylation is one of the most noted regulatory mechanisms mediating signaling mechanisms during physiological stresses. To expand our knowledge of the potential phosphoproteomic changes in the myocardium during I/R, we used Isobaric Tags for Relative and Absolute Quantitation-based analyses in left ventricular samples obtained from porcine hearts under control or I/R conditions. The data are available via ProteomeXchange with identifier PXD006066. We identified 1,896 phosphopeptides within left ventricular control and I/R porcine samples. Significant differential phosphorylation between control and I/R groups was discovered in 111 phosphopeptides from 86 proteins. Analysis of the phosphopeptides using Motif-x identified five motifs: (..R..S..), (..SP..), (..S.S..), (..S…S..), and (..S.T..). Semiquantitative immunoblots confirmed site location and directional changes in phosphorylation for phospholamban and pyruvate dehydrogenase E1, two proteins known to be altered by I/R and identified by this study. Novel phosphorylation sites associated with I/R were also identified. Functional characterization of the phosphopeptides identified by our methodology could expand our understanding of the signaling mechanisms involved during I/R damage in the heart as well as identify new areas to target therapeutic strategies.NEW & NOTEWORTHY We used Isobaric Tags for Relative and Absolute Quantitation technology to investigate the phosphoproteomic changes that occur in cardiac tissue under ischemia-reperfusion conditions. The results of this study provide an extensive catalog of phosphoproteins, both predicted and novel, associated with ischemia-reperfusion, thereby identifying new pathways for investigation.
Widespread Use of Misidentified Cell Line KB (HeLa): Incorrect Attribution and Its Impact Revealed through Mining the Scientific Literature
Authors: Vaughan Liwen , Glänzel Wolfgang , Korch Christopher , Capes-Davis Amanda 
Published: April 2017

Abstract
Continuous cell lines are widely used, but can result in invalid, irreproducible research data. Cell line misidentification is a common problem that can be detected by authentication testing; however, misidentified cell lines continue to be used in publications. Here we explore the impact of one misidentified cell line, KB (HeLa), on the scientific literature. We identified 574 articles between 2000 and 2014 that provided an incorrect attribution for KB, in accordance with its false identity as oral epidermoid carcinoma, but only 57 articles that provided a correct attribution for KB, as HeLa or cervical adenocarcinoma. Statistical analysis of 57 correct and 171 incorrect articles showed that the number of citations to these articles increased over time. Content analysis of 200 citing articles showed there was a tendency to describe the cell line in accordance with the description in the cited paper. Analysis of journal impact factor showed no significant difference between correct and incorrect groups. Articles using KB or citing that usage were most frequently published in the subject areas of pharmacology, pharmacy, oncology, and medicinal chemistry. These findings are important for science policy and support the need for journals to require authentication testing as a condition of publication. Cancer Res; 77(11); 2784–8. ©2017 AACR.
CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer
Authors: Wang Dingzhi , Sun Haiyan , Wei Jie , Cen Bo , DuBois Raymond N. 
Published: April 2017

Abstract
Emerging evidence suggests that the primary tumor influences the development of supportive metastatic microenvironments, referred to as premetastatic niches, in certain distant organs before arrival of metastatic cells. However, the mechanisms underlying the contributions of the primary tumor to premetastatic niche formation are not fully understood. Here, we demonstrate that colorectal carcinoma cells secrete VEGFA, which stimulates tumor-associated macrophages to produce CXCL1 in the primary tumor. Elevation of CXCL1 in premetastatic liver tissue recruited CXCR2-positive myeloid-derived suppressor cells (MDSC) to form a premetastatic niche that ultimately promoted liver metastases. Importantly, premetastatic liver-infiltrating MDSCs induced tumor cell survival without involvement of innate or adaptive immune responses. Our study provides the first evidence that primary malignant cell-secreted VEGFA stimulates tumor-associated macrophages to produce CXCL1, which recruits CXCR2-positive MDSCs to form a premetastatic niche to promote liver metastases. Our findings not only shed light on how the tumor microenvironment contributes to premetastatic niche formation at distant sites, but they also provide comprehensive insights into how MDSCs are recruited to other organs where they contribute to metastatic spread of disease. Moreover, our work also provides a rationale for development of CXCR2 antagonists to inhibit or prevent metastatic spread of disease. Cancer Res; 77(13); 3655–65. ©2017 AACR.