bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microplasma Jet Arrays as a Therapeutic Choice for Fungal Keratitis
Authors: Park Hyun Jung , Kim Soon Hee , Ju Hyung Woo , Lee Hyesook , Lee Yoonjin , Park Sehyun , Yang Heejun , Park Sung-Jin , Eden J. Gary , Yang Jaewook , Park Chan Hum 
Published: January 2018

AbstractThe clinical impact of microplasma jets on rabbit eyes infected by Candida albicans has been investigated. Arrays of such jets produce low-temperature plasma micro-columns suitable for ophthalmic therapeutics and fungal infections, in particular, and the technology is capable of being scaled to surface areas of at least 10 cm2. Keratitis was induced in the right central corneas of rabbits, whereas the left eyes served as a normal group. The rabbits were divided into the plasma non-treated group (control) and plasma treatment group. Histologic analyses of both groups showed marked reductions in the thickness, angiogenesis, and opacity of all rabbit corneas following plasma treatment. Indeed, for treatment times beyond 14 days, infected eyes exhibited no significant differences from the normal group. Healing of rabbit eyes infected by Candida albicans apparently proceeds by disrupting corneal epithelial proliferation, and by reducing fibrotic changes in the stroma. This study demonstrates that low-temperature plasma jets are remarkably effective in healing Candida albicans-infected corneas, thereby providing a promising medical treatment option for keratitis.
HOXD3 targeted by miR-203a suppresses cell metastasis and angiogenesis through VEGFR in human hepatocellular carcinoma cells
Authors: Wang Lumin , Tong Dongdong , Guo Qingqing , Wang Xiaofei , Wu Fei , Li Qian , Yang Juan , Zhao Lingyu , Qin Yannan , Liu Yingxun , Huang Chen 
Published: January 2018

AbstractHepatocellular carcinoma (HCC), one of the most common aggressive tumors worldwide has a relatively high mortality rate among malignant tumors. MicroRNAs (miRNAs), acting as tumor suppressors, are involved in the regulation of invasion, metastasis, and angiogenesis of tumor cells. However, a potential role for miR-203a in HCC has not been described yet. In this study, we show that miR-203a markedly suppresses HCC cell migration, invasion, and angiogenesis. In addition, the transcription factor HOXD3 appears to be a direct target of miR-203a. HOXD3 knockdown substantially decreased HCC cell migration, invasion, and angiogenesis, effects similar to those seen for miR-203a expression. Rescuing the function of HOXD3 attenuated the effect of miR-203a overexpression in HCC cells. Furthermore, HOXD3 can directly target the promoter region of VEGFR and increase VEGFR expression. Taken together, our findings indicate that miR-203a inhibits HCC cell invasion, metastasis, and angiogenesis by negatively targeting HOXD3 and suppressing cell signaling through the VEGFR pathway, suggesting that miR-203a might represent a potential therapeutic target for HCC intervention.
Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium
Authors: Khelloufi Mustapha-Kamel , Loiseau Etienne , Jaeger Marc , Molinari Nicolas , Chanez Pascal , Gras Delphine , Viallat Annie 
Published: January 2018

AbstractMucociliary clearance is a biomechanical mechanism of airway protection. It consists of the active transport along the bronchial tree of the mucus, a fluid propelled by the coordinated beating of a myriad of cilia on the epithelial surface of the respiratory tract. The physics of mucus transport is poorly understood because it involves complex phenomena such as long-range hydrodynamic interactions, active collective ciliary motion, and the complex rheology of mucus. We propose a quantitative physical analysis of the ciliary activity and mucus transport on a large panel of human bronchial cultures from control subjects, patients with asthma and chronic obstructive pulmonary disease obtained from endobronchial biopsies. Here we report on the existence of multiple ciliary domains with sizes ranging from the tens of a micron to the centimeter, where ciliary beats present a circular orientational order. These domains are associated with circular mucus flow patterns, whose size scales with the average cilia density. In these domains, we find that the radial increase of the ciliated cell density coupled with the increase in the orientational order of ciliary beats result in a net local force proportional to the mucus velocity. We propose a phenomenological physical model that supports our results.
Comparison between two post-dentin bond strength measurement methods
Authors: Zhu Laikuan , Li Yuping , Chen Yung-Chung , Carrera Carola A. , Wu Chong , Fok Alex 
Published: January 2018

AbstractThe push-out (PO) test and the diametral compression (DC) test were performed to compare the merits of two post-dentin bond strength measurement methods. Compared with the push-out test, the disk in DC provided post-dentin bond strength measurements that were more precise. The load-displacement curves from the DC test were much smoother and more linear up to the point of fracture when compared to those from the PO test. Compared to the PO test, DC is easier to perform for determining the bond strength between posts and dentin. No specimen alignment is needed in the DC test, and it produces a smaller standard deviation in the measured bond strength. The main disadvantage of the DC test, however, is that finite element analysis (FEA) is required to calculate the bond strength. The shear bond strength given by the PO test based on the simple formula is not valid, though, and the peak failure load is dependent on friction at the post-dentin interface.
Detecting neurodegenerative disorders from web search signals
Authors: White Ryen W. , Doraiswamy P. Murali , Horvitz Eric 
Published: January 2018

AbstractNeurodegenerative disorders, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), are important public health problems warranting early detection. We trained machine-learned classifiers on the longitudinal search logs of 31,321,773 search engine users to automatically detect neurodegenerative disorders. Several digital phenotypes with high discriminatory weights for detecting these disorders are identified. Classifier sensitivities for PD detection are 94.2/83.1/42.0/34.6% at false positive rates (FPRs) of 20/10/1/0.1%, respectively. Preliminary analysis shows similar performance for AD detection. Subject to further refinement of accuracy and reproducibility, these findings show the promise of web search digital phenotypes as adjunctive screening tools for neurodegenerative disorders.
Australia’s continental-scale acoustic tracking database and its automated quality control process
Authors: Hoenner Xavier , Huveneers Charlie , Steckenreuter Andre , Simpfendorfer Colin , Tattersall Katherine , Jaine Fabrice , Atkins Natalia , Babcock Russ , Brodie Stephanie , Burgess Jonathan , Campbell Hamish , Heupel Michelle , Pasquer Benedicte , Proctor Roger , Taylor Matthew D. , Udyawer Vinay , Harcourt Robert 
Published: January 2018

AbstractOur ability to predict species responses to environmental changes relies on accurate records of animal movement patterns. Continental-scale acoustic telemetry networks are increasingly being established worldwide, producing large volumes of information-rich geospatial data. During the last decade, the Integrated Marine Observing System’s Animal Tracking Facility (IMOS ATF) established a permanent array of acoustic receivers around Australia. Simultaneously, IMOS developed a centralised national database to foster collaborative research across the user community and quantify individual behaviour across a broad range of taxa. Here we present the database and quality control procedures developed to collate 49.6 million valid detections from 1891 receiving stations. This dataset consists of detections for 3,777 tags deployed on 117 marine species, with distances travelled ranging from a few to thousands of kilometres. Connectivity between regions was only made possible by the joint contribution of IMOS infrastructure and researcher-funded receivers. This dataset constitutes a valuable resource facilitating meta-analysis of animal movement, distributions, and habitat use, and is important for relating species distribution shifts with environmental covariates.
Promoting Peer Interaction for Preschool Children With Complex Communication Needs and Autism Spectrum Disorder
Authors: Therrien Michelle C. S. , Light Janice C. 
Published: January 2018

Purpose
This study investigates the impact of a multicomponent intervention on the social communication and engagement of preschool children with complex communication needs (CCN) and autism spectrum disorder (ASD) and peers without disabilities.

Method
Five dyads of children participated in this research. A multiple probe design across dyads was used to evaluate the effects of intervention on the frequency of communicative turns expressed by children with CCN and ASD in interactions with peers. Frequency of peer turns, percentage of turns taken by peers, and joint engagement were investigated to assess the quality of the interaction. The intervention included (a) provision of a communication app on an Apple iPad Air 2 and (b) dyadic turn-taking training.

Results
Four of the 5 participants with CCN completed training and increased independent communicative turn-taking with peers. The 5th participant showed increased turn-taking during training but little change in independent turn-taking. All peers took more turns in intervention than in baseline, with no negative impact on the turn balance between participants. Average joint engagement increased for all dyads, although session-to-session variability was high.

Conclusion
The results from this study provide support for the use of this intervention to promote peer interaction for children with CCN and ASD.

Supplemental Material

https://doi.org/10.23641/asha.5829678
Early evolution of viscous and self-gravitating circumstellar disks with a dust component
Authors: Vorobyov Eduard I. , Akimkin Vitaly , Stoyanovskaya Olga , Pavlyuchenkov Yaroslav , Liu Hauyu Baobab 
Published: January 2018

Context. Aims. The long-term evolution of a circumstellar disk starting from its formation and ending in the T Tauri phase was simulated numerically with the purpose of studying the evolution of dust in the disk with distinct values of the viscous α-parameter and dust fragmentation velocity vfrag.
Methods. We solved numerical hydrodynamics equations in the thin-disk limit, which were modified to include a dust component consisting of two parts: sub-micron-sized dust, and grown dust with a maximum radius ar. The former is strictly coupled to the gas, while the latter interacts with the gas through friction. Dust growth, dust self-gravity, and the conversion of small to grown dust were also considered.
Results. We found that the process of dust growth that is known for the older protoplanetary phase also holds for the embedded phase of the disk evolution. The dust growth efficiency depends on the radial distance from the star – ar is largest in the inner disk and gradually declines with radial distance. In the inner disk, ar is limited by the dust fragmentation barrier. The process of small-to-grown dust conversion is very fast once the disk is formed. The total mass of the grown dust in the disk (beyond 1 AU) reaches tens or even hundreds of Earth masses as soon as in the embedded phase of star formation, and an even greater amount of grown dust drifts in the inner, unresolved 1 AU of the disk. Dust does not usually grow to radii greater than a few cm. A notable exception are models with α ≤ 10−3, in which case a zone with reduced mass transport develops in the inner disk and dust can grow to meter-sized boulders in the inner 10 AU. Grown dust drifts inward and accumulates in the inner disk regions. This effect is most pronounced in the α ≤ 10−3 models, where several hundreds of Earth masses can be accumulated in a narrow region of several AU from the star by the end of embedded phase. The efficiency of grown dust accumulation in spiral arms is stronger near corotation where the azimuthal velocity of dust grains is closest to the local velocity of the spiral pattern. In the framework of the adopted dust growth model, the efficiency of small-to-grown dust conversion was found to increase for lower values of α and vfrag.
Formation of interstellar methanol ice prior to the heavy CO freeze-out stage
Authors: Qasim D. , Chuang K.-J. , Fedoseev G. , Ioppolo S. , Boogert A. C. A. , Linnartz H. 
Published: January 2018

Context.The formation of methanol (CH3OH) on icy grain mantles during the star formation cycle is mainly associated with the CO freeze-out stage. Yet there are reasons to believe that CH3OH also can form at an earlier period of interstellar ice evolution in CO-poor and H2O-rich ices.Aims.This work focuses on CH3OH formation in a H2O-rich interstellar ice environment following the OH-mediated H-abstraction in the reaction, CH4+ OH. Experimental conditions are systematically varied to constrain the CH3OH formation yield at astronomically relevant temperatures.Methods.CH4, O2, and hydrogen atoms are co–deposited in an ultrahigh vacuum chamber at 10–20 K. OH radicals are generated by the H + O2surface reaction. Temperature programmed desorption – quadrupole mass spectrometry (TPD–QMS) is used to characterize CH3OH formation, and is complemented with reflection absorption infrared spectroscopy (RAIRS) for CH3OH characterization and quantitation.Results.CH3OH formation is shown to be possible by the sequential surface reaction chain, CH4+ OH → CH3+ H2O and CH3+ OH → CH3OH at 10–20 K. This reaction is enhanced by tunneling, as noted in a recent theoretical investigation Lamberts et al. (2017, A&A, 599, A132). The CH3OH formation yield via the CH4+ OH route versus the CO + H route is approximately 20 times smaller for the laboratory settings studied. The astronomical relevance of the new formation channel investigated here is discussed.
Assessing Cancer Signal during Oral Antiplatelet Therapy in the Food and Drug Administration Adverse Event Reporting System: Mission Impossible
Authors: Serebruany Victor , Kim Moo , Thevathasan Christian , Marciniak Thomas 
Published: January 2018

AbstractWhether aggressive prolonged dual antiplatelet therapy (DAPT) promotes solid cancer risks remains a critical unsolved issue. Since the evidence from randomized trials, affiliated U.S. Food and Drug Administration (FDA) reviews, meta-analyses, and national registries is mixed, the search is ongoing. The FDA Adverse Event Reporting System (FAERS) is a global passive surveillance repository requiring mandatory updates for serious events. We assessed the frequencies of co-reporting any cancers with oral antiplatelet agent (OAA) strategies in FAERS. We examined the entire FAERS database (n = 8,604,889) with regard to monotherapy or DAPT with OAA, suspected causative role, and co-reporting any cancers (n = 433,111). We extracted cancer cases during monotherapy with aspirin (20,984 out of 462,371 or 4.54%), clopidogrel (2,797 out of 62,791 or 4.45%), prasugrel (119 out of 4,364 or 2.73%), and ticagrelor (144 out of 8.268 or 1.71%). DAPT with clopidogrel reported (2,453 out of 58,101, or 4.22%); prasugrel (162 out of 4,036, or 4.01%); and ticagrelor (195 out of 5,302 or 3.68%) cancer reports all on top of aspirin. We conclude that FAERS is currently unreliable for adequate assessment of cancer risks during DAPT. The retrieved evidence appears random and sporadic, while associated cancers are heavily underreported or/and missed. Without stricter rules, better surveillance, and enforcements, oncology outcome research options in FAERS are challenging.
Evaluation of Experience with Lower Extremity Arterial Injuries at an Urban Trauma Center
Authors: Franz Randall , Hill Joshua , Lieber Michael , Galante John , Tanga Christopher 
Published: January 2018

AbstractLower extremity arterial injuries (LEAIs) can be complicated injuries resulting in limb loss and death. Patients with LEAI often have multiple injuries increasing the risk for morbidity and mortality. We sought to evaluate the incidence and management of LEAI and to define associations between injuries and outcomes. We performed a retrospective review of LEAI at an urban level-1 trauma center from April 2005 to April 2015. Chi-square tests were used to compare independent groups with respect to mortality and amputation. Means were compared between independent groups using two-sample t-tests. From April 2005 to April 2015, 208 arterial injuries occurred in 163 patients. The majority (80.4%) suffered concomitant lower extremity injuries with 35.6% suffering systemic injuries. Surgical intervention was required for 72.1% of injuries. Amputation rate was 14.7%. Mortality rate was 8.0%. Data from 2010 to 2015 were more specifically analyzed. Injury severity score (ISS) was higher with fatalities (37 ± 13.16 vs. 11.8 ± 8.51, p < 0.0001) and in patients requiring an amputation (25.4 ± 15.32 compared with 11.6 ± 9.05, p = 0.0015). Popliteal artery injury was most likely to require an amputation (odds ratio [OR] = 2.9, p = 0.04). Mortality was more likely when systemic injuries were present (OR = 18.1, p = 0.0005). The majority of patients with arterial injuries require surgical management, most often with open surgical techniques. Arterial injuries associated with systemic injuries, blunt injury mechanisms, and higher ISS are at a significantly increased risk of mortality.
Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion
Authors: Chen Yi-Chun , Wu Hsiu-Mei , Chen Shih-Jen , Lee Han-Jui , Lirng Jiing-Feng , Lin Chung-Jung , Luo Chao-Bao , Guo Wan-Yuo , Chang Feng-Chi 
Published: January 2018

AbstractCosmetic facial filler-related central retinal artery occlusion (CRAO) is a devastating complication of facial hyaluronic acid (HA) injection and can be managed by intra-arterial thrombolytic therapy (IATT). The authors report on a 20-year-old woman who developed unilateral CRAO due to facial HA injection and who, despite prompt IATT, lost vision. A review of the related literature found 14 other female patients who developed cosmetic facial filler-related CRAO and accepted IATT management. In no case was vision loss clinically improved. IATT is not an effective preventive treatment of dermal filler-associated CRAO. The authors suggest careful preprocedural patient selection to prevent this complication.
Impact of Short Bowel Syndrome on Quality of Life and Family: The Patient's Perspective
Authors: Pederiva Federica , Khalil Basem , Morabito Antonino , Wood Sarah 
Published: January 2018

Background Short bowel syndrome (SBS) has an impact on children and their families not only physically, but also emotionally, mentally, and socially. This study aimed to evaluate quality of life and family impact in patients with SBS, using the Pediatric Quality of Life Inventory (PedsQL) measurement model.
Materials and Methods PedsQL questionnaires were administered to patients with SBS followed at the Pediatric Surgery of Royal Manchester Children's Hospital. The scores were compared between two groups differing in age (children <5 y vs. >5 y) and with known-groups from literature published by Varni et al.
Results Forty-three patients were sent the questionnaires, and 30 (70%, 17 < 5 and 13 > 5) responded. Family Impact Module failed to distinguish between families of children younger and older than 5 years of age. In contrast, it distinguished between families with SBS children and the ones with children in a long-term care facility. Healthcare satisfaction was worse in families of children over 5 years regarding information received, inclusion of the family, and communication. When compared with normal population, SBS children scored worse on Generic Core Scales for all domains except for emotional functioning.
Conclusion Although advances have been made on the treatment of children with SBS, and improvements have been reached on home PN, this condition is still significantly affecting the quality of life of children and their families. The future quality control of medical care must have greater focus on psychosocial and emotional functioning, aiming for the best possible quality of life.
Key comparison BIPM.RI(I)-K1 of the air-kerma standards of the SMU, Slovakia and the BIPM in 60Co gamma radiation
Authors: Kessler C , Burns D , Durný N 
Published: January 2018

A key comparison of the standards for air kerma of the Slovak Institute of Metrology (SMU), Slovakia and of the Bureau International des Poids et Mesures (BIPM) was carried out in the 60Co radiation beam of the BIPM in June 2017. The comparison result, evaluated as a ratio of the SMU and the BIPM standards for air kerma, is 1.0042 with a combined standard uncertainty of 2.7 × 10−3. The results for an indirect comparison made at the same time are consistent with the direct results at the level of 2 parts in 104. The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Fractal Uncertainty for Transfer Operators
Authors: Dyatlov Semyon , Zworski Maciej 
Published: January 2018

Abstract
We show directly that the fractal uncertainty principle of Bourgain–Dyatlov [3] implies that there exists σ &gt; 0 for which the Selberg zeta function (1.2) for a convex co-compact hyperbolic surface has only finitely many zeros with $ \textrm{Re}\, s \geq \frac 12 - \sigma $. That eliminates advanced microlocal techniques of Dyatlov–Zahl [6], though we stress that these techniques are still needed for resolvent bounds and for possible generalizations to the case of nonconstant curvature.
“Isolated” Suprascapular Neuropathy: Compression, Traction, or Inflammation?
Authors: Le Hanneur Malo , Maldonado Andres A , Howe Benjamin M , Mauermann Michelle L , Spinner Robert J 
Published: January 2018

Abstract

BACKGROUND
Several hypotheses have been proposed for the pathophysiology of suprascapular nerve (SSN) palsy, including compression, traction, and nerve inflammation.

OBJECTIVE
To provide insight into the pathophysiology of isolated nontraumatic SSN palsy by performing critical reinterpretations of electrodiagnostic (EDX) studies and magnetic resonance (MR) images of patients with such diagnosis.

METHODS
We retrospectively reviewed all patients referred to our institution for the past 20 yr with a diagnosis of nontraumatic isolated suprascapular neuropathy who had an upper extremity EDX study and a shoulder or brachial plexus MR scan. Patient charts were reviewed to analyze their initial clinical examination, and their original EDX study and MR images were reinterpreted by an experienced neurologist and a musculoskeletal radiologist, respectively, both blinded from the authors’ hypothesis and from each other's findings.

RESULTS
Fifty-nine patients were included. Fifty of them (85%) presented with at least 1 finding that was inconsistent with an isolated SSN palsy. Forty patients (68%) had signs on physical examination beyond the SSN distribution. Thirty-one patients (53%) had abnormalities on their EDX studies not related to the SSN. Twenty-two patients (37%) had denervation atrophy in other muscles than the spinati, or neural hyperintensity in other nerves than the SSN on their MR scans, without any evidence of SSN extrinsic compression.

CONCLUSION
The great majority of patients with presumed isolated SSN palsy had clinical, electrophysiological, and/or imaging evidence of a more diffuse pattern of neuromuscular involvement. These data strongly support an inflammatory pathophysiology in many cases of “isolated” SSN palsy.