bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Ligand‐Promoted C(sp3)—H Olefination en Route to Multi‐Functionalized Pyrazoles.
Authors: Yang Weibo , Ye Shengqing , Schmidt Yvonne , Stamos Dean , Yu Jin‐Quan 
Published: September 2016

AbstractA broad spectrum of pyrazole substrates bearing a quaternary carbon center at position 3 and analogue (VIa) are successfully olefinated in the presence of the amino acid ligand AIL with Cu(O‐Ac)2 as the terminal oxidant.
ChemInform Abstract: Isomerizable (E/Z)‐Alkynyl‐O‐methyl Oximes Employing TMSCl—NCS in Chlorinative Cyclization for the Direct Synthesis of 4‐Chloroisoxazoles.
Authors: Kaewsri Wilailak , Thongsornkleeb Charnsak , Tummatorn Jumreang , Ruchirawat Somsak 
Published: September 2016

AbstractThe combination of TMSCl and NCS generates Cl2 and HCl in situ and the E‐oximes can isomerize to Z‐isomers under the reaction conditions.
ChemInform Abstract: Iron‐Catalyzed Cyclization of Aminothiols: An Easy Access to Benzothiazoles and Evaluation of Their Antimicrobial and anti‐Biofilm Activities.
Authors: Vinayak Botla , Reddy Marri Anil , Chiranjeevi Barreddi , Chandrashekharam Malapaka , Poornachandra Y. , Ganesh Kumar C. 
Published: September 2016

AbstractCompound (V) bearing a carbazole moiety bridge between two benzothiazole scaffolds shows significant antimicrobial, minimum bactericidal concentration (MBC), and anti‐biofilm activities.
ChemInform Abstract: Reaction of Amidoximes with Acetonitrile at High Pressure
Authors: Baykov Sergey V. , Zharov Aleksey A. , Stashina Galina A. , Zavarzin Igor V. , Kofanov Evgeniy R. 
Published: September 2016

Abstractaffording 1,2,4‐oxadiazoles without the use of a catalyst
ChemInform Abstract: Synthesis and Characterization of New N‐Alkylated Pyridin‐2(1H)‐ones.
Authors: Sharma Atul Kumar , Yadav Preeti , Chand Karma , Sharma Sunil K. 
Published: September 2016

AbstractNovel N‐alkylated pyridinone derivatives (16 examples) are synthesized and characterized from their physical and spectral data.
ChemInform Abstract: Cobalt‐Catalyzed Oxidase C—H/N—H Alkyne Annulation: Mechanistic Insights and Access to Anticancer Agents.
Authors: Mei Ruhuai , Wang Hui , Warratz Svenja , Macgregor Stuart A. , Ackermann Lutz 
Published: September 2016

AbstractCobalt‐catalyzed alkyne annulations by C—H/N—H functionalizations are accomplished with molecular O2 as the sole oxidant.
ChemInform Abstract: Baylis—Hillman Acetates in Synthesis: Copper(I)/tert‐Butyl Hydroperoxide Promoted One‐Pot Oxidative Intramolecular Cyclization Protocol for the Preparation of Pyrrole‐Fused Compounds and the Formal Synthesis of (.+‐.)‐Crispine A.
Authors: Basavaiah Deevi , Lingaiah Balthu , Reddy Guddeti Chandrashekar , Sahu Bharat Chandra 
Published: September 2016

AbstractN‐Alkylation of tetrahydroisoquinolines or tryptoline with Baylis—Hillman acetates followed by intramolecular cyclization and oxdiative aromatization affords pyrrole‐fused compound including the precursor (VIII) of (.+‐.)‐crispine A.
ChemInform Abstract: Transition‐Metal Controlled Diastereodivergent Radical Cyclization/Azidation Cascade of 1,7‐Enynes.
Authors: Zhao Yingying , Hu Yancheng , Wang Haolong , Li Xincheng , Wan Boshun 
Published: September 2016

AbstractOptimized reaction conditions employing copper or manganese salts allow the selective formation of cis‐ or trans‐fused pyrroloquinolinone from 1,7‐enynes.
ChemInform Abstract: Tandem Approach for the Synthesis of 3‐Sulfenylimidazo[1,5‐a]pyridines from Dithioesters.
Authors: Ramesha Ajjahalli. B. , Pavan Kumar Chottanahalli. S. , Sandhya Nagarakere. C. , Kumara Manikyanahalli. N. , Mantelingu Kempegowda , Rangappa Kanchugarakoppal. S. 
Published: September 2016

AbstractA library of sulfenylimidazopyridines synthesized from dithioesters, 2‐methylaminopyridines, and sulfonyl hydrazides using iodine as the reagent under metal‐free conditions.
ChemInform Abstract: AlCl3‐Mediated Heteroarylation‐Cyclization Strategy: One‐Pot Synthesis of Fused Quinoxalines Containing the Central Core of Lamellarin D.
Authors: Kumar K. Shiva , Meesa Siddi Ramulu , Rajesham Bandari , Bhasker Boyapally , Ashfaq Mohd Ashraf , Khan Aleem Ahmed , Rao Sagurthi Someswar , Pal Manojit 
Published: September 2016

AbstractPyrano[3,4‐b]indole fused quinoxalines are synthesized from 1,2‐dichloroquinoxalines and indole‐2‐carboxylic acids using the title strategy.
ChemInform Abstract: A Palladium‐Catalyzed Tandem Reaction of 2‐Alkynylbenzenesulfonamides with 2‐(2‐Bromoarylidene)cyclobutanones.
Authors: Gong Xinxing , Xia Hongguang , Wu Jie 
Published: September 2016

Abstractaffording a range of benzothiazoninone dioxides in moderate to good yields
ChemInform Abstract: Disiloxane Synthesis Based on Silicon—Hydrogen Bond Activation Using Gold and Platinum on Carbon in Water or Heavy Water.
Authors: Sawama Yoshinari , et al.  
Published: September 2016

AbstractPreliminary investigations reveal a high catalytic activity of 10% Au, Ru, Rh, Pd and Pt on charcoal with the gold catalyst being the optimal one.
ChemInform Abstract: Isolation and Biomimetic Total Synthesis of Tomentodiones A—B, Terpenoid‐Conjugated Phloroglucinols from the Leaves of Rhodomyrtus tomentosa.
Authors: Liu Hong‐Xin , Chen Kai , Tang Gui‐Hua , Yuan Yun‐Fei , Tan Hai‐Bo , Qiu Sheng‐Xiang 
Published: September 2016

AbstractTomentodiones A (I) and B (II) exhibit marginal antibacterial activity against E.
ChemInform Abstract: Regioselective Mono and Multiple Alkylation of Diols and Polyols Catalyzed by Organotin and Its Applications on the Synthesis of Value‐Added Carbohydrate Intermediates.
Authors: Xu Hengfu , Ren Bo , Zhao Wei , Xin Xiaoting , Lu Yuchao , Pei Yuxin , Dong Hai , Pei Zhichao 
Published: September 2016

AbstractA series of 3‐alkylated pyranosides, e.g. galactopyranosides (V), is prepared by a Bu2SnCl2‐catalyzed regioselective monoalkylation.
ChemInform Abstract: First Total Synthesis of Dermocanarin 2.
Authors: Yamaguchi Satoru , Takahashi Nobuyuki , Yuyama Daisuke , Sakamoto Kayo , Suzuki Keisuke , Matsumoto Takashi 
Published: September 2016

AbstractThe synthesis of the axially chiral natural dermocanarin 2 features the construction of the anthraquinone and naphthoquinone onto an axially chiral biphenyl intermediate followed by a stereoselective aldol reaction for the implementation of the stereogenic center in the side chain.
ChemInform Abstract: SrMoO4:Er3+‐Yb3+ Upconverting Phosphor for Photonic and Forensic Applications.
Authors: Soni Abhishek Kumar , Rai Vineet Kumar 
Published: September 2016

AbstractPolycrystalline SrMoO4:Er3+(0.3 mol%),Yb3+ (1—4 mol%) codoped samples are prepared by precipitation from HNO3 solutions of SrCO3, (NH4)6Mo7O24, Er2O3, and Yb2O3 via addition of NH4OH and subsequent firing (Al2O3 crucible, ≈500 °C; annealing at ≈800 °C).
A Triazinone Derivative Inhibits HIV‐1 Replication by Interfering with Reverse Transcriptase Activity
Authors: Urano Emiko , Miyauchi Kosuke , Kojima Yoko , Hamatake Makiko , Ablan Sherimay D. , Fudo Satoshi , Freed Eric O. , Hoshino Tyuji , Komano Jun 
Published: September 2016

AbstractA novel HIV‐1 inhibitor, 6‐(tert‐butyl)‐4‐phenyl‐4‐(trifluoromethyl)‐1H,3H‐1,3,5‐triazin‐2‐one (compound 1), was identified from a compound library screened for the ability to inhibit HIV‐1 replication. EC50 values of compound 1 were found to range from 107.9 to 145.4 nm against primary HIV‐1 clinical isolates. In in vitro assays, HIV‐1 reverse transcriptase (RT) activity was inhibited by compound 1 with an EC50 of 4.3 μm. An assay for resistance to compound 1 selected a variant of HIV‐1 with a RT mutation (RTL100I); this frequently identified mutation confers mild resistance to non‐nucleoside RT inhibitors (NNRTIs). A recombinant HIV‐1 bearing RTL100I exhibited a 41‐fold greater resistance to compound 1 than the wild‐type virus. Compound 1 was also effective against HIV‐1 with RTK103N, one of the major mutations that confers substantial resistance to NNRTIs. Computer‐assisted docking simulations indicated that compound 1 binds to the RT NNRTI binding pocket in a manner similar to that of efavirenz; however, the putative compound 1 binding site is located further from RTK103 than that of efavirenz. Compound 1 is a novel NNRTI with a unique drug‐resistance profile.
Cytology smears as excellent starting material for next‐generation sequencing‐based molecular testing of patients with adenocarcinoma of the lung
Authors: Velizheva Nadezda P. , Rechsteiner Markus P. , Wong Christine E. , Zhong Qing , Rössle Matthias , Bode Beata , Moch Holger , Soltermann Alex , Wild Peter J. , Tischler Verena 
Published: September 2016

BACKGROUNDMolecular testing of lung adenocarcinomas (ADCs) is crucial for therapy stratification of patients. Because of the often limited diagnostic material, the authors aimed to explore the suitability of cytology smears for next‐generation sequencing (NGS) and compared the results with concurrent histological specimens or cell blocks.METHODSA total of 16 formalin‐fixed paraffin‐embedded (FFPE) ADCs with known genetic alterations were used as the first cohort for targeted DNA and RNA sequencing. In the second cohort of 8 cases, 8 cytological smears were compared with matching histological specimens or cell blocks for the study. For NGS library amplification, commercially available panels for DNA and RNA sequencing were applied. The Ion Torrent Personal Genome Machine and the Ion Reporter workflow (version 5.0) were used for sequencing.RESULTSAll DNA libraries derived from FFPE and non‐formalin‐fixed cytological smear samples produced acceptable quality metrics, thereby enabling successful targeted DNA sequencing (100% performance). Targeted RNA sequencing failed in 1 FFPE case and 1 cytology probe by not reaching enough mapped fusion reads (92% performance rate). All previously detected mutations and gene rearrangements could be confirmed (sensitivity of 100%), whereas specificity of the DNA‐based NGS assay reached 96%.CONCLUSIONSThe results of the current study demonstrated the suitability of non‐formalin cytology specimens for the simultaneous NGS testing of lung ADCs using amplicon resequencing panels. These assays allowed for the input of cytological smears equal to concurrent histology or cell blocks and proved to be accurate in the detection of therapeutically actionable somatic mutations and gene rearrangements. Cancer Cytopathol 2017;125:30‐40. © 2016 American Cancer Society.
Diagnosis of trichomoniasis in men by urine cytology
Authors: Doxtader Erika E. , Elsheikh Tarik M. 
Published: September 2016

BACKGROUNDTrichomonas vaginalis is a rare finding in urine cytology specimens, especially those from men; only 2 case reports have been described in the literature. The authors of the current report sought to determine the incidence and clinical significance of this finding in urine cytology in males.METHODSThe authors' cytopathology archives were queried for urine cytology specimens that contained Trichomonas over a 30‐year period. Clinical information from men with Trichomonas‐positive urines was reviewed retrospectively. Slides were reviewed, and the morphologic characteristics of the organisms were recorded.RESULTSTrichomonas was detected in 73 of 60,000 urine cytology specimens (0.1%). The patients included 45 women and 28 men. Men with Trichomonas in their urine ranged in age from 28 to 87 years (mean age, 67 years; median, 71 years). Trichomonas organisms were round to oval, with eccentric nuclei and cytoplasmic granules. Acute inflammation was observed in 6 of 7 cases. Clinical history was available in 13 of 28 men. Lower urinary tract symptoms were reported in 10 of 13 men, most commonly hematuria; and urethral strictures were identified by cystoscopy in 3 of 13 men. Clinical follow‐up was available for 10 of 13 patients; of these, 8 (80%) had received treatment with metronidazole based on urine cytology results.CONCLUSIONSThis study is the largest series of Trichomonas infection in men diagnosed by urine cytology in the literature. Most men had no prior diagnosis of trichomoniasis and received specific antibiotic therapy based on their urine cytology results. Urine cytology may represent the initial diagnostic test for Trichomonas in men, and accurate cytologic diagnosis may prevent undesired adverse outcomes for them and their partners. Cancer Cytopathol 2017;125:55‐59. © 2016 American Cancer Society.
Cytomorphology of clear cell papillary renal cell carcinoma
Authors: Lin Xiaoqi 
Published: September 2016

BACKGROUNDClear cell papillary renal cell carcinoma (CCPRCC) shares some morphologic and immunohistochemical markers with clear cell RCC and papillary RCC. To the author's knowledge, its cytomorphology on fine‐needle aspiration (FNA) or touch preparations (TPs) of core needle biopsy specimens has not been well delineated in the English language literature.METHODSThe FNA/TP cytomorphology of 7 retrieved cases was studied.RESULTSThe tumor cells were arranged in small nests (100%), 3‐dimensional clusters (71%), papillary/tubular/acinar arrays (43%), and as single cells (57%). The tumor cells were columnar (100%) and polygonal (57%) in shape, with eccentric, small, round‐to‐oval nuclei. The nuclei contained evenly distributed, fine granular chromatin and demonstrated a smooth nuclear membrane (100%) (Fuhrman grade 1 to 2). The tumor cells had a moderate amount of delicate or clear cytoplasm containing small vacuoles (100%) and ill‐defined cytoplasmic borders (100%). Scattered macrophages (57%) and necrosis (29%) were identified in the background. Vessels were noted within the papillary cores, transversing or surrounding nests of tumors. Immunochemical studies demonstrated expression of cytokeratin 7 (CK7) (100%), carbonic anhydrase IX (CA 9) (100% in a cup‐shaped membranous pattern), α‐methylacyl‐CoA racemase (AMACR) (50%), and CD10 (43%). The tumor cells were negative for CD117.CONCLUSIONSCCPRCC was found to demonstrate cytologic features that when taken together are helpful in diagnosing CCPRCC on FNA smears and TPs. If core needle biopsy specimens or cell blocks are available, an immunohistochemical panel including CK7, CA IX, CD10, and AMACR may help in excluding congeners. This subtype of RCC requires differentiation from clear cell RCC and papillary RCC due to its low‐grade indolent behavior. Cancer Cytopathol 2017;125:48‐54. © 2016 American Cancer Society.
In Vitro Drug Metabolism Using Liver Microsomes
Authors: Knights Kathleen M. , Stresser David M. , Miners John O. , Crespi Charles L. 
Published: September 2016

AbstractKnowledge of the metabolic stability of newly discovered drug candidates eliminated by metabolism is essential for predicting the pharmacokinetic (PK) parameters that underpin dosing and dosage frequency. Further, characterization of the enzyme(s) responsible for metabolism (reaction phenotyping) allows prediction, at least at the qualitative level, of factors (including metabolic drug‐drug interactions) likely to alter the clearance of both new chemical entities (NCEs) and established drugs. Microsomes are typically used as the enzyme source for the measurement of metabolic stability and for reaction phenotyping because they express the major drug‐metabolizing enzymes cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT), along with others that contribute to drug metabolism. Described in this unit are methods for microsome isolation, as well as for the determination of metabolic stability and metabolite formation (including kinetics). © 2016 by John Wiley & Sons, Inc.
The Prospecting Shortcut to an Old Molecule: Formaldehyde Synthesis at Low Temperature in Solution
Authors: Heim Leo E. , Konnerth Hannelore , Prechtl Martin H. G. 
Published: September 2016

AbstractOver 30 megatons of formaldehyde are required per year and industrially produced through three high‐temperature gas‐phase processes: i) natural gas reforming to syngas, ii) methanol synthesis, and iii) partial oxidation to formaldehyde with limited selectivity. In vast contrast to these energy‐intensive oxidative and dehydrogenative methods, a reductive “top‐down” methodology using CO2 and CO as carbon source would be desirable and is not very well present in the literature for more than 100 years. The key to success is the reaction performance in liquid solution in water or methanol at low temperature.
Effects of Intranasal Oxytocin on Long‐Term Memory in Healthy Humans: A Systematic Review
Authors: Brambilla Michela , Manenti Rosa , de Girolamo Giovanni , Adenzato Mauro , Bocchio‐Chiavetto Luisella , Cotelli Maria 
Published: September 2016

ABSTRACT

Preclinical Research

The neuropeptide oxytocin (Oxt) is implicated in complex emotional and social behaviors and appears to play an important role in learning and memory. Animal studies have shown that the effects of exogenous Oxt on memory vary according to the timing of administration, context, gender, and dose and may improve the memory of social, but not nonsocial stimuli. Oxt is intimately involved in a broad array of neuropsychiatric functions and may therefore be a pharmacological target for several psychiatric disorders. This review summarizes the potential effects of Oxt on long‐term memory processes in healthy humans based on a PubMed search over the period 1980–2016. The effects of intranasal Oxt on human memory are controversial and the studies included in this review have applied a variety of learning paradigms, in turn producing variable outcomes. Specifically, data on the long‐term memory of nonemotional stimuli found no effect or even worsening in memory, while studies using emotional stimuli showed an improvement of long‐term memory performance. In conclusion, this review identified a link between long‐term memory performance and exogenous intranasal Oxt in humans, although these results still warrant further confirmation in large, multicenter randomized controlled trials. Drug Dev Res 77 : 479–488, 2016. © 2016 Wiley Periodicals, Inc.
Genetic and environmental associations between body dissatisfaction, weight preoccupation, and binge eating: Evidence for a common factor with differential loadings across symptom type
Authors: O'Connor Shannon M. , Beam Christopher R. , Luo Xiaochen , Cohen L. Adelyn , VanHuysse Jessica L. , Emery Robert E. , Turkheimer Eric , Keel Pamela K. , Burt S. Alexandra , Neale Michael , Boker Steven , Klump Kelly 
Published: September 2016

ABSTRACTObjectivePrior twin studies provide support for a single “common factor” that contributes genetic and environmental risk to a range of disordered eating symptoms. However, the common factor may be indexed less well by binge eating (BE) than other symptoms of eating disorders [i.e., body dissatisfaction (BD) and weight preoccupation (WP)]. We sought to explore the presence of a common factor and test whether loadings differed across three key symptoms (i.e., BE, BD, WP).MethodDisordered eating was assessed via self‐report in 631 female twin pairs from the Michigan State University Twin Registry.ResultsWe detected a common disordered eating factor that was influenced primarily by additive genetic and nonshared environmental influences. However, we observed different loadings on this common factor by symptom type, as factor loadings for BD and WP were stronger than that for BE. Moreover, the residual environmental and/or genetic variances (i.e., those that are independent of the common factor) were larger in BE than those of BD or WP.DiscussionAlthough all three symptoms share a common set of genetic and environmental influences, risk for BE may involve additional genetic, biological, and environmental factors that are not shared with other symptoms of eating pathology. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2017; 50:157–161)
Swimming with the giant: coexistence patterns of a new redfin minnow Pseudobarbus skeltoni from a global biodiversity hot spot
Authors: Kadye Wilbert T. , Chakona Albert , Jordaan Martine S. 
Published: September 2016

AbstractEcological niche theory predicts that coexistence is facilitated by resource partitioning mechanisms that are influenced by abiotic and biotic interactions. Alternative hypotheses suggest that under certain conditions, species may become phenotypically similar and functionally equivalent, which invokes the possibility of other mechanisms, such as habitat filtering processes. To test these hypotheses, we examined the coexistence of the giant redfin Pseudobarbus skeltoni, a newly described freshwater fish, together with its congener Pseudobabus burchelli and an anabantid Sandelia capensis by assessing their scenopoetic and bionomic patterns. We found high habitat and isotope niche overlaps between the two redfins, rendering niche partitioning a less plausible sole mechanism that drives their coexistence. By comparison, environment–trait relationships revealed differences in species–environment relationships, making habitat filtering and functional equivalence less likely alternatives. Based on P. skeltoni's high habitat niche overlap with other species, and its large isotope niche width, we inferred the likelihood of differential resource utilization at trophic level as an alternative mechanism that distinguished it from its congener. In comparison, its congener P. burchelli appeared to have a relatively small trophic niche, suggesting that its trophic niche was more conserved despite being the most abundant species. By contrast, S. capensis was distinguished by occupying a higher trophic position and by having a trophic niche that had a low probability of overlapping onto those of redfins. Therefore, trophic niche partitioning appeared to influence the coexistence between S. capensis and redfins. This study suggests that coexistence of these fishes appears to be promoted by their differences in niche adaptation mechanisms that are probably shaped by historic evolutionary and ecological processes.
Explaining naturalization and invasiveness: new insights from historical ornamental plant catalogs
Authors: Lavoie Claude , Joly Simon , Bergeron Alexandre , Guay Geneviève , Groeneveld Elisabeth 
Published: September 2016

AbstractWe identified plant attributes associated with naturalization and invasiveness using century‐old ornamental plant catalogs from Québec (Canada). We tested the hypothesis that naturalization is determined by fewer factors than invasiveness, as the latter also requires dispersal, which introduces additional complexity. The approach we used took into account not only plant attributes as explanatory factors, but also propagule pressure, while accounting for phylogenetic relationships among species. Museum collections were used, in combination with scientific journal databases, to assess invasiveness. Particular attention was given to species that never escaped from gardens and thus represent cases of “failed” invasions. Naturalization in cold‐temperate environments is determined by fewer factors than invasion, but only if phylogenetic links between species are taken into account, highlighting the importance of phylogenetic tools for analyzing species pools not resulting from a random selection of taxa. Hardiness is the main factor explaining naturalization in Québec. Invasion requires dispersal, as shown by three significant variables associated with the spread of diaspores in the invasiveness model (seed weight, hydrochory, number of seed dispersal modes). Plants that are not cold‐hardy are likely to disappear from the market or nature, but the disappearance phenomenon is more complex, involving also seed dispersal abilities and propagule pressure. Factors contributing to naturalization or invasiveness may differ greatly between regions. Differences are due in part to the plant traits used in the models and the methodology. However, this study, conducted in a cold‐temperate region, sheds new light on what is likely a context (climatic)‐dependant phenomenon.