bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE MUSCLES TREASURY SURVEY. II. INTRINSIC LYα AND EXTREME ULTRAVIOLET SPECTRA OF K AND M DWARFS WITH EXOPLANETS*
Authors: Youngblood Allison , France Kevin , Loyd R. O. Parke , Linsky Jeffrey L. , Redfield Seth , Schneider P. Christian , Wood Brian E. , Brown Alexander , Froning Cynthia , Miguel Yamila , Rugheimer Sarah , Walkowicz Lucianne 
Published: June 2016

ABSTRACT
The ultraviolet (UV) spectral energy distributions (SEDs) of low-mass (K- and M-type) stars play a critical role in the heating and chemistry of exoplanet atmospheres, but are not observationally well-constrained. Direct observations of the intrinsic flux of the Lyα line (the dominant source of UV photons from low-mass stars) are challenging, as interstellar H i absorbs the entire line core for even the closest stars. To address the existing gap in empirical constraints on the UV flux of K and M dwarfs, the MUSCLES Hubble Space Telescope Treasury Survey has obtained UV observations of 11 nearby M and K dwarfs hosting exoplanets. This paper presents the Lyα and extreme-UV spectral reconstructions for the MUSCLES targets. Most targets are optically inactive, but all exhibit significant UV activity. We use a Markov Chain Monte Carlo technique to correct the observed Lyα profiles for interstellar absorption, and we employ empirical relations to compute the extreme-UV SED from the intrinsic Lyα flux in ∼100 Å bins from 100–1170 Å. The reconstructed Lyα profiles have 300 km s−1 broad cores, while >1% of the total intrinsic Lyα flux is measured in extended wings between 300 and 1200 km s−1. The Lyα surface flux positively correlates with the Mg ii surface flux and negatively correlates with the stellar rotation period. Stars with larger Lyα surface flux also tend to have larger surface flux in ions formed at higher temperatures, but these correlations remain statistically insignificant in our sample of 11 stars. We also present H i column density measurements for 10 new sightlines through the local interstellar medium.
ANGULAR MOMENTUM REGULATES ATOMIC GAS FRACTIONS OF GALACTIC DISKS
Authors: Obreschkow D. , Glazebrook K. , Kilborn V. , Lutz K. 
Published: June 2016

ABSTRACT
We show that the mass fraction

f

atm

=
1.35

M

H

I

/

M

of neutral atomic gas (H i and He) in isolated local disk galaxies of baryonic mass

M

is well described by a straightforward stability model for flat exponential disks. In the outer disk parts, where gas at the characteristic dispersion of the warm neutral medium is stable in the sense of Toomre, the disk consists of neutral atomic gas; conversely, the inner part where this medium would be Toomre-unstable, is dominated by stars and molecules. Within this model,

f

atm

only depends on a global stability parameter

q
≡
j
σ

/

(
GM
)

, where j is the baryonic specific angular momentum of the disk and σ the velocity dispersion of the atomic gas. The analytically derived first-order solution

f

atm

=
min
{
1
,
2.5

q

1.12

}

provides a good fit to all plausible rotation curves. This model, with no free parameters, agrees remarkably well (±0.2 dex) with measurements of

f

atm

in isolated local disk galaxies, even with galaxies that are extremely H i-rich or H i-poor for their mass. The finding that

f

atm

increasing monotonically with q for pure stability reasons offers a powerful intuitive explanation for the mean variation of

f

atm

with

M

: in a cold dark matter universe, galaxies are expected to follow

j
∝

M

2

/

3

, which implies the average scaling

q
∝

M

−
1

/

3

and hence

f

atm

∝

M

−
0.37

, in agreement with the observations.
Agua fresca para Avita y joyas de inmortalidad para Isis (CIL II 3386)
Authors: Alvar Ezquerra Jaime 
Published: June 2016

Résumé En 2012 les Presses universitaires de Franche-Comté publièrent mon livre Los cultos egipcios en Hispania , où dans le commentaire correspondant au numéro 168 du catalogue, j’avais présenté une interprétation hypothétique d’une base de qualité extraordinaire. Dans cet article j’explore plus profondément la suggestion initiale avec des parallèles iconographiques et des appuis textuels pour soutenir l’idée d’une connaissance assez vaste de la théologie isiaque dans quelques-unes des cités privilégiées des provinces romaines d’ Hispania .
Le livre d’Esther et la face cachée de Dieu, Hester Panim . Une lumière sur la Shoah
Authors: Weill Marie-David 
Published: June 2016

Dans la réflexion théologique sur la Shoah, la référence au livre d’Esther n’est pas fréquente. Pourtant, le thème de la « face cachée » de Dieu, Hester Panim , qui consonne avec le Dieu caché d’ Esther et les masques sous lesquels les Juifs dissimulent leur face lors de la fête de Pourim , donne une lumière nouvelle sur l’insupportable silence de Dieu dans la tragédie orchestrée par les nazis.
Une invitation aux enquêtes transnationales
Authors: Vari-Lavoisier Ilka 
Published: June 2016

<p class="resume">Cette contribution propose un retour sur une enquête collective, interdisciplinaire et transnationale menée entre le Sénégal et la France. L’envie de comprendre les dimensions économiques et sociales des transferts d’argent des migrants sénégalais vivant en France a donné naissance à un dispositif empirique original : l’enquête « Terrains Interdisciplinaires et Multi-sites : Migrations et Engagements » (TIMME).</p>
Migrations internationales et variations sur l’échelle du village global dans la mondialisation
Authors: Milazzo Josepha 
Published: June 2016

<p class="resume">Les municipalités villageoises, en apparence excentrées des métropoles, ne sont ni en marge des processus liés à la mondialisation ni à l’écart des dynamiques migratoires internationales. Comment alors interroger l’intégration de ces espaces dans la mondialisation ? Comment analyser le rôle de la migration internationale dans le développement de ces espaces ? Observer l’évolution de ces espaces villageois et la participation de la migration à leurs transformations requiert du chercheur un regard distancié à l’égard des paradigmes urbains dominants qui font des villes globales et des métropoles les points de référence analytiques de la mondialisation et de la migration. Telle est la posture proposée par cet article qui interroge les transformations de Cadaqués dans la mondialisation : un village touristique espagnol catalan, semi-périphérique, non-métropolitain et côtier, dont la population résidente se compose pour plus d’un tiers de migrants étrangers. Pour ce faire, je discute l’opérationnalité d’un concept recyclé, le village global. Dans ce cadre théorique, interroger les rapports entre l’échelle, les formes d’incorporation des migrants et les transformations de l’espace, permet de comprendre comment ce village a évolué et évolue. Plus généralement, ceci nous montre que les modes distincts d’organisation de l’espace et des sociétés au sein des villages, ne cessent - comme dans les villes -, de changer avec la mondialisation.</p>
Synthetic Amphipathic Helical Peptides Targeting CD36 Attenuate Lipopolysaccharide-Induced Inflammation and Acute Lung Injury
Authors: Bocharov Alexander V. , Wu Tinghuai , Baranova Irina N. , Birukova Anna A. , Sviridov Denis , Vishnyakova Tatyana G. , Remaley Alan T. , Eggerman Thomas L. , Patterson Amy P. , Birukov Konstantin G. 
Published: June 2016

Abstract
Synthetic amphipathic helical peptides (SAHPs) designed as apolipoprotein A-I mimetics are known to bind to class B scavenger receptors (SR-Bs), SR-BI, SR-BII, and CD36, receptors that mediate lipid transport and facilitate pathogen recognition. In this study, we evaluated SAHPs, selected for targeting human CD36, by their ability to attenuate LPS-induced inflammation, endothelial barrier dysfunction, and acute lung injury (ALI). L37pA, which targets CD36 and SR-BI equally, inhibited LPS-induced IL-8 secretion and barrier dysfunction in cultured endothelial cells while reducing lung neutrophil infiltration by 40% in a mouse model of LPS-induced ALI. A panel of 20 SAHPs was tested in HEK293 cell lines stably transfected with various SR-Bs to identify SAHPs with preferential selectivity toward CD36. Among several SAHPs targeting both SR-BI/BII and CD36 receptors, ELK-B acted predominantly through CD36. Compared with L37pA, 5A, and ELK SAHPs, ELK-B was most effective in reducing the pulmonary barrier dysfunction, neutrophil migration into the lung, and lung inflammation induced by LPS. We conclude that SAHPs with relative selectivity toward CD36 are more potent at inhibiting acute pulmonary inflammation and dysfunction. These data indicate that therapeutic strategies using SAHPs targeting CD36, but not necessarily mimicking all apolipoprotein A-I functions, may be considered a possible new treatment approach for inflammation-induced ALI and pulmonary edema.
The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor–Mediated Cross-Linking
Authors: Overdijk Marije B. , Jansen J. H. Marco , Nederend Maaike , Lammerts van Bueren Jeroen J. , Groen Richard W. J. , Parren Paul W. H. I. , Leusen Jeanette H. W. , Boross Peter 
Published: June 2016

Abstract
Emerging evidence suggests that FcγR-mediated cross-linking of tumor-bound mAbs may induce signaling in tumor cells that contributes to their therapeutic activity. In this study, we show that daratumumab (DARA), a therapeutic human CD38 mAb with a broad-spectrum killing activity, is able to induce programmed cell death (PCD) of CD38+ multiple myeloma tumor cell lines when cross-linked in vitro by secondary Abs or via an FcγR. By comparing DARA efficacy in a syngeneic in vivo tumor model using FcRγ-chain knockout or NOTAM mice carrying a signaling-inactive FcRγ-chain, we found that the inhibitory FcγRIIb as well as activating FcγRs induce DARA cross-linking–mediated PCD. In conclusion, our in vitro and in vivo data show that FcγR-mediated cross-linking of DARA induces PCD of CD38-expressing multiple myeloma tumor cells, which potentially contributes to the depth of response observed in DARA-treated patients and the drug’s multifaceted mechanisms of action.
Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis
Authors: Su Pan , Chen Sheng , Zheng Yu Han , Zhou Hai Yan , Yan Cheng Hua , Yu Fang , Zhang Ya Guang , He Lan , Zhang Yuan , Wang Yanming , Wu Lei , Wu Xiaoai , Yu Bingke , Ma Li Yan , Yang Zhiru , Wang Jianhua , Zhao Guixian , Zhu Jinfang , Wu Zhi-Ying , Sun Bing 
Published: June 2016

Abstract
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS characterized by demyelination and axonal damage. Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model for human MS. Although Th17 cells are important for disease induction, Th2 cells are inhibitory in this process. In this article, we report the effect of a Th2 cell product, extracellular matrix protein 1 (ECM1), on the differentiation of Th17 cells and the development of EAE. Our results demonstrated that ECM1 administration from day 1 to day 7 following the EAE induction could ameliorate the Th17 cell responses and EAE development in vivo. Further study of the mechanism revealed that ECM1 could interact with αv integrin on dendritic cells and block the αv integrin–mediated activation of latent TGF-β, resulting in an inhibition of Th17 cell differentiation at an early stage of EAE induction. Furthermore, overexpression of ECM1 in vivo significantly inhibited the Th17 cell response and EAE induction in ECM1 transgenic mice. Overall, our work has identified a novel function of ECM1 in inhibiting Th17 cell differentiation in the EAE model, suggesting that ECM1 may have the potential to be used in clinical applications for understanding the pathogenesis of MS and its diagnosis.
Seismic structure beneath the Gulf of Aqaba and adjacent areas based on the tomographic inversion of regional earthquake data
Authors: El Khrepy Sami , Koulakov Ivan , Al-Arifi Nassir , Petrunin Alexey G. 
Published: June 2016

Abstract. We present the first 3-D model of seismic P and S velocities in the crust and uppermost mantle beneath the Gulf of Aqaba and surrounding areas based on the results of passive travel time tomography. The tomographic inversion was performed based on travel time data from ∼ 9000 regional earthquakes provided by the Egyptian National Seismological Network (ENSN), and this was complemented with data from the International Seismological Centre (ISC). The resulting P and S velocity patterns were generally consistent with each other at all depths. Beneath the northern part of the Red Sea, we observed a strong high-velocity anomaly with abrupt limits that coincide with the coastal lines. This finding may indicate the oceanic nature of the crust in the Red Sea, and it does not support the concept of gradual stretching of the continental crust. According to our results, in the middle and lower crust, the seismic anomalies beneath the Gulf of Aqaba seem to delineate a sinistral shift (∼ 100 km) in the opposite flanks of the fault zone, which is consistent with other estimates of the left-lateral displacement in the southern part of the Dead Sea Transform fault. However, no displacement structures were visible in the uppermost lithospheric mantle.
Current Status and Future Prospects for Aptamer-Based Mycotoxin Detection
Authors: Ruscito Annamaria , Smith McKenzie , Goudreau Daniel N , DeRosa Maria C 
Published: June 2016

Abstract
Aptamers are single-stranded oligonucleotides with the ability to bind tightly and selectively to a target analyte. High-affinity and specific aptamers for a variety of mycotoxins have been reported over the past decade. Increasingly, these molecular recognition elements are finding applications in biosensors and assays for the detection of mycotoxins in a variety of complex matrixes. This review article highlights the mycotoxin aptamers that are available for mycotoxin detection and the array of biosensing platforms into which they have been incorporated. Key advantages that aptamers have over analogous technology, and areas in which these advantages may be applied for the benefit of practical mycotoxin detection, are also discussed.
Les dispositifs d’intervention clinique en institution
Authors: Pinel Jean-Pierre 
Published: June 2016

Cet article présente de manière synthétique la théorisation et la découpe originales de l’intervention clinique en institution en référence au modèle que Jean-Claude Rouchy nous a proposé. Il présente et discute trois repères essentiels à la compréhension de sa démarche méthodologique : le concept de dispositif ; la place de l’analyste ; les différents dispositifs d’analyse en institution. Ce modèle offre un repérage particulièrement précieux pour le clinicien, trouvant ainsi un adossement fiable et consistant lui permettant de résister créativement à la déliaison, voire au chaos, qu’il rencontre de plus en plus massivement dans sa clinique d’intervention, soumise aux bouleversements du méta-cadre contemporain.
« L’enfant-dossier » : la bienveillance au risque de sa perversion
Authors: Aubourdy Florence 
Published: June 2016

L’évaluation, nouvelle égérie technico-scientifique, pilotant la réforme du système structurel et le style de gestion des écoles, dans un souci d’efficacité et d’efficience, déshumanise les pratiques pédagogiques et développe un climat anxiogène, peu propice à l’apprentissage. Cette impasse du désir, par une logique d’« enfant-dossier », menace les structures symboliques et la construction même de la pensée. Cette répétition perverse dévoile la face obscure des bonnes intentions, réminiscence du passé de l’Occident.
Theoretical and experimental determination of the crystal structures of cesium–molybdenum chloride
Authors: Saito Norio , Wada Yoshiki , Lemoine Pierric , Cordier Stéphane , Grasset Fabien , Ohsawa Takeo , Saito Noriko , Cross Jeffrey S. , Ohashi Naoki 
Published: June 2016

Abstract
We herein report the structure-property relationships of the octahedral molybdenum metal cluster compound, Cs2[Mo6Cl14]. Using purified samples, we attempted to determine if Cs2[Mo6Cl14] possesses crystalline polarity. Heat treatment was performed prior to characterization to remove impurities, as X-ray powder diffraction and Fourier transformation infrared spectroscopy studies suggested the unit cell of Cs2[Mo6Cl14] expanded with the insertion of water molecules and/or hydroxyl moieties. Geometry optimization and total energy calculations by density functional theory calculations were conducted to determine whether Cs2[Mo6Cl14] crystallizes in centrosymmetric (

) or non-centrosymmetric (P31c) space groups. Furthermore, the results of the optical studies, along with the absence of a second harmonic generation, and the observation of a strong third harmonic generation, supported the hypothesis that inversion symmetry exists in the Cs2[Mo6Cl14] lattice. The space group of Cs2[Mo6Cl14] was therefore identified as

symmetry.
A Machine Learning Method for Allocating Scarce COVID-19 Monoclonal Antibodies
Authors: Xiao Mengli , Molina Kyle C. , Aggarwal Neil R. , Beaty Laurel E. , Bennett Tellen D. , Carlson Nichole E. , Fish Lindsey E. , Hamer Mika K. , Kwan Bethany M. , Mayer David A. , Peers Jennifer L. , Wynia Matthew K. , Ginde Adit A. 
Published: September 2024

ImportanceDuring the COVID-19 pandemic, the effective distribution of limited treatments became a crucial policy goal. Yet, limited research exists using electronic health record data and machine learning techniques, such as policy learning trees (PLTs), to optimize the distribution of scarce therapeutics.ObjectiveTo evaluate whether a machine learning PLT-based method of scarce resource allocation optimizes the treatment benefit of COVID-19 neutralizing monoclonal antibodies (mAbs) during periods of resource constraint.Design, Setting, and ParticipantsThis retrospective cohort study used electronic health record data from October 1, 2021, to December 11, 2021, for the training cohort and data from June 1, 2021, to October 1, 2021, for the testing cohort. The cohorts included patients who had positive test results for SARS-CoV-2 and qualified for COVID-19 mAb therapy based on the US Food and Drug Administration’s emergency use authorization criteria, ascertained from the patient electronic health record. Only some of the qualifying candidates received treatment with mAbs. Data were analyzed between from January 2023 to May 2024.Main Outcomes and MeasuresThe primary outcome was overall expected hospitalization, assessed as the potential reduction in overall expected hospitalization if the PLT-based allocation system was used. This was compared to observed allocation using risk differences.ResultsAmong 9542 eligible patients in the training cohort (5418 female [56.8%]; age distribution: 18-44 years, 4151 [43.5%]; 45-64 years, 3146 [33.0%]; and ≥65 years, 2245 [23.5%]), a total of 3862 (40.5%) received mAbs. Among 6248 eligible patients in the testing cohort (3416 female [54.7%]; age distribution: 18-44 years, 2827 [45.2%]; 45-64 years, 1927 [30.8%]; and ≥65 years, 1494 [23.9%]), a total of 1329 (21.3%) received mAbs. Treatment allocation using the trained PLT model led to an estimated 1.6% reduction (95% CI, −2.0% to −1.2%) in overall expected hospitalization compared to observed treatment allocation in the testing cohort. The visual assessment showed that the PLT-based point system had a larger reduction in 28-day hospitalization compared with the Monoclonal Antibody Screening Score (maximum overall hospitalization difference, −1.0% [95% CI, −1.3% to −0.7%]) in the testing cohort.Conclusions and RelevanceThis retrospective cohort study proposes and tests a PLT method, which can be linked to a electronic health record data platform to improve real-time allocation of scarce treatments. Use of this PLT-based allocation method would have likely resulted in fewer hospitalizations across a population than were observed in usual care, with greater expected reductions than a commonly used point system.
Innate Immune Response and Epigenetic Regulation: A Closely Intertwined Tale in Inflammation
Authors: Jawale Diksha , Khandibharad Shweta , Singh Shailza 
Published: September 2024

AbstractMaintenance of delicate homeostasis is very important in various diseases because it ensures appropriate immune surveillance against pathogens and prevents excessive inflammation. In a disturbed homeostatic condition, hyperactivation of immune cells takes place and interplay between these cells triggers a plethora of signaling pathways, releasing various pro‐inflammatory cytokines such as Tumor necrosis factor alpha (TNFα), Interferon‐gamma (IFNƴ), Interleukin‐6 (IL‐6), and Interleukin‐1 beta (IL‐1β), which marks cytokine storm formation. To be precise, dysregulated balance can impede or increase susceptibility to various pathogens. Pathogens have the ability to hijack the host immune system by interfering with the host's chromatin architecture for their survival and replication in the host cell. Cytokines, particularly IL‐6, Interleukin‐17 (IL‐17), and Interleukin‐23 (IL‐23), play a key role in orchestrating innate immune responses and shaping adaptive immunity. Understanding the interplay between immune response and the role of epigenetic modification to maintain immune homeostasis and the structural aspects of IL‐6, IL‐17, and IL‐23 can be illuminating for a novel therapeutic regimen to treat various infectious diseases. In this review, the light is shed on how the orchestration of epigenetic regulation facilitates immune homeostasis.
Substrate Curvature‐Induced Regulation of Charge Distribution of Covalent Organic Frameworks Promotes Capacitive Deionization
Authors: Jiang Dong , Xu Ruibo , Bai Liang , Hill Jonathan P. , Henzie Joel , Zhu Liyang , Xia Wei , Bu Ran , Zhao Yingji , Kang Yunqing , Hamada Takashi , Ma Renzhi , Torad Nagy , Wang Jie , Asahi Toru , Xu Xingtao , Yamauchi Yusuke 
Published: September 2024

AbstractCovalent organic frameworks (COFs) are promising high‐performance capacitive deionization (CDI) materials. Strategies to optimize CDI performance of COFs focus largely on hybridization with conductive substrates, to improve their their intrinsically poor conductivity. A new structure‐function relationship between COFs and their substrates is proposed here based on substrate‐induced surface curvature. Graphene (zero‐curvature) and carbon nanotubes (CNT, curved) are selected as COF growthsubstrates to assess the effect of curvature engineering effect on CDI performance of TpPa‐SO3H‐COF. Ultrahigh ion (Na+) adsorption capacity (58.74 mg g−1) is achieved by CNT‐COF hybrid (cf. compared to graphene‐COF hybrid 34.20 mg g−1), demonstrating the significance of curvature engineering. Notably, the corresponding salt (NaCl) adsorption capacity of CNT‐COF hybrid reaches 149.25 mg g−1 in 1000 ppm at 1.2 V, representing state‐of‐the‐art CDI performance, and the highest value among organic CDI electrodes. X‐ray photoelectron spectroscopy and theoretical calculations subsequently reveal that substrate curvature can induce local strain, which regulates charge distribution within the COF skeleton, causing a lower binding energy state for Na+ adsorption. Electrochemical quartz crystal microbalance measurements revealed faster Na+ adsorption kinetics of CNT‐COF due to regulated charge distribution within COF skeleton induced by substrate curvature. This work gives new insight into design of COF materials based on curvature engineering.