bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
Authors: Raina Kanak , Lu Jing , Qian Yimin , Altieri Martha , Gordon Deborah , Rossi Ann Marie K. , Wang Jing , Chen Xin , Dong Hanqing , Siu Kam , Winkler James D. , Crew Andrew P. , Crews Craig M. , Coleman Kevin G. 
Published: June 2016

SignificanceWe describe the development of a small molecule that mediates the degradation of bromodomain and extra-terminal (BET) proteins and its application in the treatment of castration-resistant prostate cancer (CRPC). Few therapeutic options exist to treat CRPC, especially CRPC tumors expressing constitutively active androgen receptor (AR) splice variants that lack the ligand-binding domain and can effect androgen-independent transactivation of target genes. Importantly, we demonstrate that targeted degradation of BET proteins using proteolysis-targeting chimera (PROTAC) technology causes cell death in cultured prostate cancer cells and results in tumor growth inhibition or regression in mouse models of CRPC, including models that express high levels of AR splice variant 7. Our work thus contains a significant potential therapeutic advance in the treatment of this cancer.
Development of a promoter shutoff system in Aspergillus oryzae using a sorbitol-sensitive promoter
Authors: Oda Ken , Terado Shiho , Toyoura Rieko , Fukuda Hisashi , Kawauchi Moriyuki , Iwashita Kazuhiro 
Published: June 2016

Abstract
Promoter shutoff is a general method for analyzing essential genes, but in the fungus Aspergillus oryzae, no tightly repressed promoters have been reported. To overcome the current limitations of conditional promoters, we examined sorbitol- and galactose-responsive genes using microarrays to identify regulatable genes with only minor physiological and genetic effects. We identified two sorbitol-induced genes (designated as sorA and sorB), cloned their promoters, and built a regulated egfp and brlA expression system. Growth medium-dependent enhanced green fluorescence protein (EGFP) fluorescence and conidiation were confirmed for egfp and brlA under the control of their respective promoters. We also used this shutoff system to regulate the essential rhoA, which demonstrated the expected growth inhibition under repressed growth conditions. Our new sorbitol promoter shutoff system developed can serve as a valuable new tool for essential gene analyses of filamentous fungi.
Degradation products of mangiferin by gamma irradiation with inhibitory effects on NO production
Authors: Jo Cheorun , Yoon Kyung Young , Jang Eun Jin , Kim Tae Hoon 
Published: June 2016

Abstract
The xanthone glucoside mangiferin (1) was converted by γ-irradiation into three new compounds, mangiferdiol (2), mangiferinol (3), and isomangiferinol (4). The new compound 2 containing two hydroxymethyl groups instead of a ketone moiety exhibited significantly improved inhibitory activity against nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 value 47.1 ± 1.7 μM, compared to the mother mangiferin.
A Declining Farm Workforce: Analysis of Panel Data from Rural Mexico
Authors: Charlton Diane , Taylor J. Edward 
Published: June 2016

AbstractAnalysis of nationally representative individual‐level panel data from 1980 to 2010 reveals a significant negative trend in the agricultural labor supply from rural Mexico, which is the primary source of hired workers for U.S. farms. These findings offer an explanation for the rise over time in U.S. farm wages. Concomitants of the agricultural transformation, including growth in the non‐farm economy, falling birth rates, and an increase in rural education, accelerate the transition of rural Mexicans out of farm work. Higher U.S. farm wages and increased border enforcement slow the transition, but the combined impact of these offsetting variables is relatively small. A diminishing farm labor supply has far‐reaching implications for farmers, farm labor organizers, rural communities, and agricultural workers.
Effectiveness of computer-aided learning in oral health among patients and caregivers: a systematic review
Authors: Ab Malik Normaliza , Zhang Jiaguan , Lam Otto Lok Tao , Jin Lijian , McGrath Colman 
Published: June 2016

Computer-aided learning (CAL) offers enormous potential in disseminating oral health care information to patients and caregivers. The effectiveness of CAL, however, remains unclear.Objectives: The purpose of this study was to systematically review published evidence on the effectiveness of CAL in disseminating oral health care information to patients and caregivers.Materials and Methods: A structured comprehensive search was undertaken among 7 electronic databases (PUBMED, CINAHL Plus, EMBASE, SCOPUS, WEB of SCIENCE, the Cochrane Library, and PsycINFO) to identify relevant studies. Randomized controlled trials (RCTs) and observational studies were included in this review. Papers were screened by 2 independent reviewers, and studies that met the inclusion criteria were selected for further assessment.Results: A total of 2915 papers were screened, and full texts of 53 potentially relevant papers (κ = 0.885) were retrieved. A total of 5 studies that met the inclusion criteria (1 RCT, 1 quasi-experimental study, and 3 post-intervention studies) were identified. Outcome measures included knowledge, attitude, behavior, and oral health. Significant improvements in clinical oral health parameters (P &lt; .05) and knowledge/attitudes (P &lt; .001) were reported in 2 of the studies. The 3 remaining studies reported improved oral health behaviors and confidence.Conclusion: There is a limited number of studies which have examined the effectiveness of CAL interventions for oral health care among patients and caregivers. Synthesis of the data suggests that CAL has positive impacts on knowledge, attitude, behavior, and oral health. Further high- quality studies on the effectiveness of CAL in promoting oral health are warranted.
A novel use of the discrete templated notes within an electronic health record software to monitor resident supervision
Authors: Ban Vin Shen , Madden Christopher J , Browning Travis , O’Connell Ellen , Marple Bradley F , Moran Brett 
Published: June 2016

Abstract
Objective: Monitoring the supervision of residents can be a challenging task. We describe our experience with the implementation of a templated note system for documenting procedures with the aim of enabling automated, discrete, and standardized capture of documentation of supervision of residents performing floor-based procedures, with minimal extra effort from the residents.
Materials and methods: Procedural note templates were designed using the standard existing template within a commercial electronic health record software. Templates for common procedures were created such that residents could document every procedure performed outside of the formal procedural areas. Automated reports were generated and letters were sent to noncompliers.
Results: A total of 27 045 inpatient non–formal procedural area procedures were recorded from August 2012 to June 2014. Compliance with NoteWriter template usage averaged 86% in the first year and increased to 94.6% in the second year (P = .0055).
Initially, only 12.5% of residents documented supervision of any form. By the end of the first year, this was above 80%, with the gains maintained into the second year and beyond. Direct supervision was documented to have occurred where required in 62.8% in the first year and increased to 99.8% in the second year (P = .0001) after the addition of hard stops. Notification of attendings prior to procedures was documented 100% of the time by September 2013. Letters sent to errant residents decreased from 3.6 to 0.83 per 100 residents per week.
Conclusion: The templated procedure note system with hard stops and integrated reporting can successfully be used to improve monitoring of resident supervision. This has potential impact on resident education and patient safety.
Synthesis of phosphorylated rust metamorphoses and its comparative corrosion study on steel samples simulated in different atmospheres
Authors: Jain Rachna , Sharma Amit , Bhadu Manish Kumar , Swarnkar Keshave 
Published: June 2016

Purpose
The aim of this study was to evaluate the corrosion inhibition efficiency of steel samples in different environments before and after the treatment with rust metamorphose (RM), which is formulated in this research study and shows excellent adherence over the rusted surface of substrate because of the presence of the P-O-Fe bond.

Design/methodology/approach
An RM solution (phosphorylated polyphenol) was synthesised and characterised using Fourier transform infrared spectroscopy (FT-IR), and then the degree of protection offered by it to steel surfaces with and without the treatment with the RM solution in different atmospheres was evaluated;. Before and after treating with the RM solution, the corroded steel samples were characterised using X-ray diffraction (XRD), FT-IR, scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The study of the passive behaviours of the corroded steel samples and RM-treated steel samples was done in different simulated atmospheres.

Findings
This RM solution is phosphorylated polyphenol solution (proved by FT-IR), which acts as a corrosion inhibitor on corroded steel surfaces because of the formation of a passive and symmetric adherent layer of phosphorylated polyphenol–iron complex (confirmed by FT-IR, XRD, EDS, SEM and adhesion X test). The significant improvement in corrosion resistance in splash conditions of 3.5 per cent NaCl, tap water and 1.5 per cent Na2SO4 was found with the treatment of phosphorylated polyphenol-based RM.

Originality/value
The development of RM and its characterisation with performance evaluation in different atmospheres is a novel approach in this research.
Preparation and research of electroless nickel on carbon fiber surfaces
Authors: Shao Zhongcai , Guo Jian , Liu Pin 
Published: June 2016

Purpose
The paper aims to introduce the process flow of electroless nickel (EN) plating on carbon fiber surfaces, the effect of former processing on the properties of coating and the dynamics of the process.

Design/methodology/approach
The coated fibers were mounted in cold-setting epoxy resin, and transverse cross-section of the coated fibers were examined under an optical microscope to ascertain the thickness, uniformity and continuity of the coating over the fiber surface. The coating morphology was studied by using a scanning electron microscope (SEM). This study also determined the activation energy and electrical properties of EN coated on carbon fibers.

Findings
Activation temperatures have a greater impact on the quality of EN. At a temperature of 80°C, the EN layer prepared was uniform and compact and fully coated the carbon fibers. The optimum components of the EN plating process is NiSO4: 28 g/L; NaH2PO2: 30 g/L; NaAc: 20 g/L; Na3C6H5O7:10 g/L; C4O6H2KNa: 2 g/L; (NH4)2SO4: 18 g/L; thiourea and lead acetate: trace; operating conditions: pH = 8.5, temperature: 70°C; time: 0.5 h). The activation energy of the EN plating on carbon fiber is 12 kJ/mol, and the electrical conductivity of nickel-plated carbon fiber in 80 mL of distilled water is 16.5 μs/cm.

Originality/value
This paper determined the optimum processing conditions and the activation energy of the EN plating on carbon fiber.
Evolution of international and Chinese anti-bribery and corruption compliance programs
Authors: Schonfelder Karen , Velamuri S. Ramakrishna , Liu Wilson 
Published: June 2016

Purpose
The purpose of this study is to explore the regulatory framework in China and the extent to which Chinese multinationals have implemented and disclosed their anti-bribery and corruption (ABC) compliance practices. This is done against the backdrop of the evolving international ABC compliance standards.

Design/methodology/approach
This study is based on detailed reviews of the ABC compliance standards of international organizations; legislation passed by the USA, the UK and Chinese Governments; seven semi-structured interviews with leading experts in the field; and comparisons of ABC program disclosures of four Chinese with four best-in-class western multinational corporations.

Findings
A high level of convergence was found in the ABC standards published by the international organizations. Several positive features were found in the Chinese ABC regulatory frameworks but our findings indicate that there is minimal disclosure around ABC compliance program practices. This paper shows that a transparent disclosure would represent an easy win for Chinese multinational corporations and contribute to raising their reputations internationally.

Research limitations/implications
While there are numerous studies in the law literature on ABC compliance standards and the extent to which they are effective in achieving their objectives, this is an emergent area in management research, to which our study makes a contribution. Future research could explore how other emerging economies are tackling this important issue.

Practical implications
By proactively adopting ABC compliance practices, corporations can seize the ethical high ground and build solid reputations with their stakeholders.

Originality/value
It is believed that this study is the first academic study that compares Chinese and international ABC standards.
Re: duplication of corporate governance codes and the dilemma of firms with dual regulatory jurisdictions
Authors: Bello Lawal 
Published: June 2016

Purpose
This paper aims to examine the evolution of corporate governance in Nigeria and how the duplication of code of corporate best practices is impacting compliance with the key recommendations of these guidelines. The issues of corporate governance and reforms especially those related to the development and implementation of code of corporate best practices have been a subject of academic discuss over the years with more research emphasis placed on developed economies. This paper intends to add the sub-Sahara Africa and the emerging economic perspective to this vibrant stream of research.

Design/methodology/approach
This paper adopts an explanatory approach in the review of the four different codes of corporate governance that were issued in Nigeria in the past ten years.

Findings
The paper demonstrated that corporate governance has been a fundamental issue of concern in Nigerian public enterprises since the country gained independence in 1960. The paper equally established that the application of recent corporate governance reforms has been challenged, not on competency grounds but rather by the proliferation of codes which have created implementation and monitoring difficulties for both the affected firms and the regulatory agencies.

Originality/value
Unlike other previous studies, this paper offers comprehensive analysis of corporate governance evolution in Nigeria and found through documented literatures that shortage of experienced local personnel and the absence of effective external control mechanisms have been the bane against the development of corporate governance in Nigeria. The originality of this paper also lies in being the first paper to have linked developments in the public enterprises to the renewed focus on corporate governance. This is the most inclusive paper to have identified key implications of multiplicity of corporate governance codes and the direct application of governance system within the context of the country’s socio-cultural distinctiveness.
Board director disciplinary and cognitive influence on corporate value creation
Authors: Toumi Nadia , Benkraiem Ramzi , Hamrouni Amal 
Published: June 2016

Purpose
This paper aims to investigate board director disciplinary and cognitive influence on corporate value creation.

Design/methodology/approach
Fixed-effect regressions are used to check whether gender diversity, education, independence and size of the board of directors affect measures of corporate value creation.

Findings
The empirical results show that corporate value creation is positively influenced by the cross effect of the board independence and the presence of women. They also point out a positive impact of the cross effect of board independence and management education. They reveal that the board of directors contributes significantly to corporate value creation, particularly when there is a mix of independent, female and management-qualified directors.

Originality/value
The evidence presented and discussed in this paper should be of interest to managers and regulators. The methodological approach and the empirical results extend the existing literature. They enrich the limited empirical research devoted to this theme, especially in a continental European context, i.e. France. They shed light on the effect of board of directors’ disciplinary and cognitive influence on corporate value creation.
Why are couples fighting? A need frustration perspective on relationship conflict and dissatisfaction
Authors: Vanhee Gaëlle , Lemmens Gilbert M. D. , Stas Lara , Loeys Tom , Verhofstadt Lesley L. 
Published: June 2016

AbstractThe present study investigated whether partners’ frustration of relational needs for autonomy, competence, and relatedness was associated with relationship dissatisfaction and conflict (frequency, topics, communication patterns). Self‐report measures were completed by 230 committed heterosexual couples. APIM and regression analyses revealed that (1) need frustration is associated with how dissatisfied partners are with their relationship, how frequently they initiate conflict, and how they communicate during conflicts, but not with the number of conflict topics; (2) relatedness‐frustration matters most, whereas only limited evidence was found for autonomy‐ and competence‐frustration; (3) both one's own and one's partner's need frustration play a role in dissatisfaction and conflict; and (4) although most of the results were consistent across gender, gender differences were found for how need frustration affects couples’ conflict communication. Therapeutic implications are discussed.Practitioner points

Addressing need frustration in couples may help to reduce relationship dissatisfaction, conflict, and destructive conflict communication
Therapists should especially focus on relatedness‐frustration of men and women, but also pay attention to their autonomy‐frustration
Destructive conflict communication patterns in couples reflect relatedness‐frustration in both men and women and autonomy‐ and competence‐frustration in men.
Chlorogenic Acid Oxidation and Its Reaction with Sunflower Proteins to Form Green‐Colored Complexes
Authors: Wildermuth Sabrina R. , Young Erin E. , Were Lilian M. 
Published: June 2016

AbstractSunflower seeds are used to produce oil for human consumption, but its protein meal by‐product has long been used as animal feed. Formation of green‐colored complexes through oxidized chlorogenic acid(CGA)‐protein interactions is a primary reason why defatted sunflower protein has not been widely utilized by the food industry. Sunflower protein possesses many properties that make it an appealing alternative protein source from both a marketing and formulation perspective, including its low cost, absence of major allergens, low antitrypsin inhibitors, and its status as both vegan and “clean” label friendly. With the global demand for sunflower oil and novel protein sources expected to increase and waste recovery a concern for many, providing uses for the sunflower meal and its fiber and polyphenol components would provide added value to by‐products from sunflower oil processing. This review addresses the unique green pigmentation associated with the interaction of sunflower protein and oxidized CGA by outlining the sunflower oil and protein meal market, CGA reactions contributing to greening, methods for CGA extraction, and the effect of processing on sunflower protein quality and the greening reaction. This review also addresses potential food applications of sunflower protein‐based ingredients, such as addition of texturized protein to food products; a microencapsulation matrix for antioxidants; edible, flexible biodegradable films; and even use of sunflower butter as an alternative to peanut butter where the green color is not considered undesirable. Continued studies are needed to make sunflower‐based products and CGA‐extraction processes available across the global marketplace.
Temporal Check‐All‐That‐Apply Characterization of Syrah Wine
Authors: Baker Allison K. , Castura John C. , Ross Carolyn F. 
Published: June 2016

AbstractTemporal Check‐All‐That‐Apply (TCATA) is a new dynamic sensory method for which analysis techniques are still being developed and optimized. In this study, TCATA methodology was applied for the evaluation of wine finish by trained panelists (n = 13) on Syrah wines with different ethanol concentrations (10.5% v/v and 15.5% v/v). Raw data were time standardized to create a percentage of finish duration, subsequently segmented into thirds (beginning, middle, and end) to capture panel perception. Results indicated the finish of the high ethanol treatments lasted longer (approximately 12 s longer) than the low ethanol treatment (P ≤ 0.05). Within each finish segment, Cochran's Q was conducted on each attribute and differences were detected amongst treatments (P ≤ 0.05). Pairwise tests showed the high ethanol treatments were more described by astringency, heat/ethanol burn, bitterness, dark fruit, and spices, whereas the low ethanol treatment was more characterized by sourness, red fruit, and green flavors (P ≤ 0.05). This study demonstrated techniques for dealing with the data generated by TCATA. Furthermore, this study further characterized the influence of ethanol on wine finish, and by extension wine quality, with implications to winemakers responsible for wine processing decisions involving alcohol management.
Non‐Nuclear Weapons States Must Lead in Shaping International Norms on Nuclear Weapons: A Practitioner Commentary
Authors: Chan Maritza 
Published: June 2016

AbstractNuclear weapons States continue to defy their responsibilities for achieving nuclear, as well as general and complete, disarmament while they simultaneously hold non‐nuclear States to their non‐proliferation commitments. Costa Rica is part of that non‐nuclear armed majority. We take a firm stand that the lack of legal prohibition of nuclear weapons constitutes a legal anomaly among weapons of mass destruction. As such, Costa Rica is committed to encouraging negotiations towards a treaty establishing new legal obligations to ban nuclear weapons once and for all. The time has come for a new era of nuclear politics in which the non‐nuclear majority of States can lead the way in charting the course towards a non‐nuclear world.
Keratoacanthoma formation after skin grafting: A brief report and pathophysiological hypothesis
Authors: Lee Senhong , Coutts Ian , Ryan Andrew , Stavrakoglou Anastasios 
Published: June 2016

AbstractKeratoacanthoma formation after skin grafting is rare. We report the third case in the literature of multiple keratoacanthomas developed at both split‐thickness skin graft donor and recipient sites. We provide possible explanations for this poorly understood phenomenon and highlight its implications on treatment options.