bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mind the gap between the tip of the plate and the tibial stem of the revision knee prosthesis – a survey with orthopaedic trauma surgeons
Authors: Caravellos Renato , Nery Filipe , de Souza Nicolle Barreto , Labronici Pedro , Freitas Anderson , Giordano Vincenzo 
Published: October 2024

Abstract

Purpose
In the herein study, we assessed the preferences among experienced orthopaedic surgeons regarding plate size and location when treating a distal tibia fracture in a patient with a revision stem of a total knee prosthesis. We aimed to determine how the stem size of the tibial component of the prosthesis influenced the choices of locking plates.
Methods
An online-based survey was sent to 35 members of the Brazilian Orthopaedic Trauma Association, consisting of eight multiple-choice questions addressing aspects of the management of lower limb injuries, including two scenarios of fractures of the distal tibia in the presence of a revision stem of a total knee prosthesis. Four large fragment locking plate lengths were used, ranging from 8 to 14 holes, whereas two different stem lengths were used, a 50-mm tibial stem and an 80-mm tibial stem. This gave to the participants 4 possibilities for each experimental situation. Descriptive and inferential analysis of the answers were performed, with a p-value of .05.
Results
For the 50-mm tibial stem, 48.6% of the surgeons chose the 8-hole plate, while 51.4% chose longer plates (10, 12 or 14-hole) (p > .05). In the presence of an 80-mm stem, the majority (57.1%) of the respondents opted for the 8-hole plate, with 42.9% choosing longer plates (p > .05). The choice for longer plates was more common among more experienced surgeons in treating tibia fractures (> 15 cases a year), and this was statistically significant (88.9% for the 50-mm tibial stem; p = 0.022) and (93.3% for the 80-mm stem; p = 0.014).
Conclusion
The presence and size of a revision tibial stem in a total knee prosthesis influence the choice of plate length for the fixation of a distal tibia fracture, and there is controversy among orthopaedic surgeons regarding the best construction for the tested scenarios. More experienced surgeons prefer longer plates, and this is statistically significant.
Prediction of M2 with early-stage hepatocellular carcinoma based on Nomogram
Authors: Xia Guoyi , Yu Zeyan , Lu Shaolong , Wang Xiaobo , Zhao Yuanquan , chen jie 
Published: October 2024

Abstract

Background
Microvascular invasion (MVI) is a crucial factor for early recurrence and poor outcomes in hepatocellular carcinoma (HCC). However, there are few studies on M2 classification. We aimed to build a predictive model for M2 in early-stage HCC, assisting clinical decision-making.
Methods
We retrospectively enrolled 451 patients with early-stage HCC and employed multiple machine learning algorithms to identify the risk factors influencing the robustness of M2. Model performance was evaluated using receiver operating characteristic (ROC) curve, calibration curve, decision curve analysis (DCA), and clinical impact curve (CIC).
Results
There were 363 M0-1 and 88 M2 cases. Differences in recurrence-free survival(RFS) and overall survival(OS) between the M0-1 and M2 groups were statistically significant (P < 0.0001). Complement C3, tumor size > 5cm, incomplete tumor capsule, and Edmondson-Steiner stage III-IV were independent risk factors for M2.The prediction model showed an area under the receiver operating characteristic curve(AUROC) of 0.765 and 0.807 in the training and validation groups, respectively. Calibration curves showed good agreement between actual and predicted M2 risks, and the DCA and CIC showed a significant clinical efficacy.
Conclusion
The nomogram-based model had a good predictive effect for M2 in patients with early-stage HCC ,providing guidance for treatment decisions.
Intracranial Dural Arteriovenous Fistulas with Deep Venous Drainage: A Single-Center Retrospective Cohort Study
Authors: Su Xin , Song Zihao , Chen Yiguang , Huang Mingyue , Liu Huiwei , Zhang Chao , Pang Huishen , Sun Liyong , Ye Ming , Hong Tao , Ma Yongjie , Zhang Hongqi , Zhang Peng 
Published: October 2024

Abstract

Objective
Dural arteriovenous fistulas (DAVFs) with deep venous drainage (DVD) (DAVFs-DVD) are characteristically associated with nonhemorrhagic neurological deficits, most notably cognitive impairment. Large studies have yet to thoroughly characterize these DAVFs. We conducted an analysis of the largest cohort of DAVFs-DVD to provide a comprehensive characterization of this specific subset.
Methods
This study was a retrospective cohort analysis of 207 patients with DAVFs-DVD who were hospitalized at a single medical center between 2002 and 2022. Logistic regression was employed to identify angiographic features specific to DAVFs associated with cognitive impairment. Additionally, post-treatment outcomes were evaluated.
Results
DAVFs-DVDs can be classified into two categories: the Galenic group, where arterial feeders drain directly into the vein of Galen (VoG), and the non-Galenic group, where arterial feeders drain into other veins or venous sinuses and indirectly flow into the VoG. Cognitive impairment accounting for 15.9% of all clinical presentations. We found that the overall rate of complete occlusion was 86.6%, while the overall rate of complications was 16.4%. Moreover, patients with DAVFs-DVD presenting with cognitive impairment were more likely to have straight sinus stenosis or occlusion, as well as DAVFs located at the midline.
Conclusion
DAVFs-DVDs can be classified into two categories: the Galenic group and the non-Galenic group. Patients with DAVFs-DVD presenting with cognitive impairment were more likely to have straight sinus stenosis or occlusion, as well as DAVFs located at the midline. Venous hypertension of the deep venous system is a key angiographic feature of DAVFs associated with thalamic cognitive impairment.
Dietary patterns trends of US adults with undiagnosed and diagnosed hyperlipidemia and their relationship with long-term mortality: NHANES 2007-2018
Authors: Xu Liang , Yu Wenjie , Que Dongdong , Yan Jing , Zhang Xiuli , Zhu Yingqi , Wang Yuxi , Yang Yashu , Song Xudong , Yang Pingzhen 
Published: October 2024

Abstract

Background
Dietary intervention is an important component of treating hyperlipidemia. There are many people with undiagnosed hyperlipidemia, and the dietary patterns of population with undiagnosed and diagnosed hyperlipidemia in US have not been studied. The purpose of this study was to explore the dietary pattern trends of the population with undiagnosed and diagnosed hyperlipidemia in the past decade and their correlation with mortality.
Methods
The sample data came from the National Health and Nutrition Examination Survey from 2007 to 2018. The dietary patterns were assessed using Dietary Inflammatory Index (DII) and Healthy Eating Index (HEI). The relationship between DII and HEI and mortality in individuals with hyperlipidemia were evaluated by Cox proportional hazards model. We conducted subgroup analysis to evaluate the potential relationship between DII and HEI and covariates.
Results
Of 29897 individuals included, 9815 without hyperlipidemia (age: weighted mean [WM] 39.91 years; 95% confidence interval [CI] 39.31–40.51; male: weighted proportion 49.4%), 9815 with undiagnosed hyperlipidemia (age: WM 45.65 years; 95% CI 45.08–46.23; male: weighted proportion 55.3%), and 10817 with diagnosed hyperlipidemia (age: WM 57.33 years; 95% CI 56.82–57.83; male: weighted proportion 50%). The proportion of population with undiagnosed hyperlipidemia shown an upward trend. The DII of each group showed an increasing trend, while the HEI showed a decreasing trend. Compared with participants with diagnosed hyperlipidemia, the participants with undiagnosed hyperlipidemia had higher DII (WM: 1.11; 95% CI: 1.04–1.18 versus WM: 0.94; 95% CI: 0.86–1.02) and lower HEI (WM: 50.26; 95% CI: 49.71–50.81 versus WM: 52.38; 95% CI: 51.84–52.93). The median follow-up time for survival analysis was 9.7 years, and high DII (hazard ratio [HR]: 1.09; 95% CI: 1.03–1.15) and low HEI (HR per 1 SD increase: 0.89; 95% CI: 0.81–0.98) were associated with an increased risk of all-cause mortality in individuals with hyperlipidemia.
Conclusions
From 2011 to 2018, the dietary health and inflammatory potential of US adults were deteriorating, especially those with undiagnosed hyperlipidemia. High DII and Low HEI are associated with an increased risk of all-cause mortality.
Characteristics of Genetically Confirmed Familial Hypercholesterolemia in Chinese Patients with Coronary Heart Disease
Authors: Wang Yihan , Li Chuang , Zhao Wenshu , Dong Ying , Wang Peijia 
Published: October 2024

Abstract

Background
Familial hypercholesterolemia (FH) is a genetically inherited disorder caused by monogenic mutations or polygenic deleterious variants. Patients with FH innate with significantly elevated risks for coronary heart disease (CHD). FH prevalence based on genetic testing in Chinese CHD patients is missing. Whether classical index of coronary atherosclerosis severity can be used as indicators of FH needs to be explored. To investigate the FH prevalence in Chinese CHD patients and the association of SYNTAX I score with FH genotype.
Methods
The monogenic and polygenic FH related genes were genotyped in 400 consecutively enrolled CHD patients. The clinical characteristics and SYNTAX I scores were analyzed in a retrospective nested case-control study.
Results
The prevalence of genetically confirmed FH in our CHD cohort was 8.75%. The cLDL-C level, SYNTAX I scores and incidences of triple vessel lesions in FH patients were significantly higher, while cLDL-C and SYNTAX I scores were independent risk factors for FH. Furthermore, cLDL-C levels of polygenic FH were significantly lower than monogenic FH, while their severity of coronary atherosclerosis was comparable.
Conclusions
Our study revealed a genetically confirmed FH prevalence of 8.75% in a Chinese CHD cohort. Additionally, the SYNTAX I score was an independent risk factor for FH. Besides, polygenic origin of FH should be taken into consideration for CHD patients suspected of FH.
The discovery and molecular mechanism of the subversion of human E3 ligase RNF213 by the Shigella effector IpaH1.4
Authors: Pan Lifeng , Zhou Xindi , Zhang Huijing , Wang Yaru , Wang DanNi , Lin Zhiqiao , Zhang Yuchao , Tang Yubin , Liu Jianping , Yao Yu-Feng , Zhang Yixiao 
Published: October 2024

Abstract

Ubiquitination plays vital roles in modulating pathogen-host cell interactions. RNF213, a unique E3 ligase, can catalyze the ubiquitination of lipopolysaccharide (LPS) and is crucial for antibacterial immunity in mammals. Shigella flexneri, an LPS-containing pathogenic bacterium, has developed mechanisms to evade host antibacterial defenses during infection. However, the precise strategies by which S. flexneri circumvents RNF213-mediated antibacterial immunity remain poorly understood. Here, through comprehensive biochemical, structural and cellular analyses, we reveal that the E3 effector IpaH1.4 of S. flexneri can directly target human RNF213 via a specific interaction between the IpaH1.4 LRR domain and the RING domain of RNF213, and mediate the ubiquitination and proteasomal degradation of RNF213 in cells. Furthermore, we determine the cryo-EM structure of human RNF213 and the crystal structure of the IpaH1.4 LRR/RNF213 RING complex, elucidating the molecular mechanism underlying the specific recognition of RNF213 by IpaH1.4. Finally, our cell-based function asaays demonstrate that the targeting of host RNF213 by IpaH1.4 promotes S. flexneri proliferation within infected cells. In summary, our work uncovers a novel strategy employed by S. flexneri to subvert the key host immune factor RNF213, thereby facilitating bacterial proliferation during invasion.
Exploring Nurse Perspectives on AI-Based Shift Scheduling for Fairness, Transparency, and Work-Life Balance
Authors: Gerlach Maisa , Fabienne Josefine Renggli , Jannic Stefan Bieri , Murat Sariyar , Golz Christoph 
Published: October 2024

Abstract

Introduction
Work-life balance (WLB) is critical to nurse retention and job satisfaction in healthcare. Traditional shift scheduling, characterised by inflexible hours and limited employee control, often leads to stress and perceptions of unfairness, contributing to high turnover rates. AI-based scheduling systems offer a promising solution by enabling fairer and more transparent shift distribution. This study explored the perspectives of nurse managers, permanent nurses, and temporary nurses on the perceived fairness, transparency, and impact on work-life balance of AI-based shift scheduling systems.
Methods
A qualitative study design was used, with focus group (FG) interviews conducted between May and June 2024. The sample consisted of 21 participants from different healthcare settings, including acute hospitals, home care services and nursing homes in German-speaking Switzerland. The interviews were analysed using the knowledge mapping method, which allowed for a visual representation of key discussion points, highlighting consensus among participants. The focus group discussions revolved around five main themes, such as experiences with current scheduling systems, expectations of AI-based scheduling, and its potential advantages and disadvantages.
Results
Participants reported that current scheduling practices often lacked fairness and transparency, leading to dissatisfaction, particularly among permanent nurses. While temporary staff appreciated the flexibility in their schedules, permanent nurses expressed a desire for more autonomy and fairness in shift allocation. AI-based scheduling has the potential to improve shift equity by objectively managing shifts based on pre-defined criteria, thereby reducing bias and administrative burden. However, participants raised concerns about the depersonalisation of scheduling, emphasising the need for human oversight to consider the emotional and contextual factors that AI systems may overlook.
Conclusion
AI-based scheduling systems could offer significant benefits in improving fairness, transparency and work-life balance for caregivers. However, the integration of these systems must be accompanied by careful consideration of the human element and ongoing collaboration with healthcare professionals to ensure that the technology is aligned with organisational needs. By striking a balance between AI-driven efficiency and human judgement, healthcare organisations can improve nurse satisfaction and retention, ultimately benefiting patient care and organisational efficiency.
Cemento-osseous dysplasia: a multi-centre analysis of surgical management
Authors: Titinchi Fadi , Alturki Naser , Morkel Jean , Alkaabi Salem , Taylor Kathryn 
Published: October 2024

Abstract

Purpose
Cemento-osseous dysplasia (COD) is a fibro-osseous lesion whose management is highly controversial in the literature. Due to scarcity of comprehensive studies on its management, the aim of this study was to analyse its management and develop a treatment protocol.
Methods
A multi-centre retrospective cohort analysis was conducted at two tertiary referral hospitals on 124 patients diagnosed with COD from 2005–2023. Demographic, clinical, and radiological data were analysed and correlated with treatment methods. Post-operative complications such as osteomyelitis or pathological fracture were documented along with follow-up visits to evaluate the need for further treatment. Data was analysed using Student’s t-test and Fisher’s exact test. Statistical significance was set at P < 0.05
Results
The patients’ ages ranged from 22–78 years (mean: 48.5 years), with majority being females (90.4%) and of African descent (95.9%). Radiopaque CODs presented significantly higher rate of symptoms compared to radiolucent or mixed lesions (p = 0.02). The majority of incidental CODs were managed through observation (72%), while six incidental CODs underwent biopsy due to suspicion of more sinister lesions. Symptomatic lesions were mainly treated by curettage (29.7%) or local excision (48.6%), while only one symptomatic case was managed with observation and antibiotics (p = 0.0001).
Conclusion
Biopsy of asymptomatic COD should only be reserved for cases with inconclusive clinico-pathological features. The decision to surgically treat COD should be based on the presence of symptoms and infection. Early curettage or excision of infected COD is the most effective approach to eradicate the disease and prevent progression into osteomyelitis.
Effects of Six Weeks of Watermelon Juice supplementation on Total Antioxidant Capacity in Elite Taekwondo Athletes
Authors: aghabeighiamin parvin , Azizi Mohammad , tahmasebi worya 
Published: October 2024

Abstract

Introduction and objective:The natural product watermelon contains a high concentration of antioxidants that have the potential to mitigate the oxidative damage resulting from the generation of free radicals post-exercise. As such, this study aims to explore the impact of six weeks of watermelon juice supplementation on the antioxidant capacity of elite female taekwondo athletes.
Methods: In a study involving twenty-five young female elite taekwondo players with a mean age of 21.84±2.26 years, participants were randomly assigned to either the watermelon juice group (n=15) or the placebo group (n=10). Over six weeks, subjects consumed 500 ml of watermelon juice or placebo 45 minutes before each of their three weekly training sessions. The Total Antioxidant Capacity (TAC) index was measured in selected athletes undergoing training at the Taekwondo House in Kermanshah, located in western Iran.
Results: The study found that following six weeks of intervention, watermelon juice supplementation led to a significant increase in total antioxidant capacity (TAC) (p=0.001), while the TAC levels in the placebo (PLA) group remained relatively unchanged (p=0.490). Moreover, participants in the watermelon juice group demonstrated higher VO2max compared to the placebo group, and experienced significantly lower levels of muscle soreness at 24 and 48 hours post-exercise (p>0.05).
Conclusions: A six-week regimen of watermelon juice supplementation has been found to enhance overall antioxidant capacity and alleviate muscle soreness.
Mental Health from Childhood to Early Adolescence and its impact on School Attendance Problems: A Latent Transition Analysis
Authors: Sharpe Jane , Heary Caroline , Bunting Brendan 
Published: October 2024

Abstract

Despite concerted efforts among policy makers and practitioners, School Attendance Problems (SAPs) are increasing, with post covid figures indicating higher than ever rates of absenteeism. The aim of this paper was to examine how the developmental trajectory of emotional and behavioural difficulties from childhood to early adolescence might impact the frequency of chronic absenteeism and truancy at 13 years. Using a sample (N = 8570) from the Longitudinal Growing Up In Ireland Study (GUI’98), the research used Latent Class Analysis (LCA) and Latent Transition Analysis (LTA) to examine combinations of mental health symptoms at 9 and 13 years and their developmental impact on SAPs. The Strengths and Difficulty Questionnaire (SDQ) was used to measure a range of emotional and behavioural difficulties at both time points, yielding four mental health classes. Children who remained in High Risk classes, had higher odds of chronic absenteeism and/or truancy. Movement between classes significantly altered the odds of truancy, but not chronic absenteeism, highlighting the importance of differentiating between SAPs and early intervention. A secondary aim was to investigate how family, school and socio-demographic risk factors impacted those trajectories. Family factors were significantly linked to transitions into the co-morbid class, indicating that family risk factors can negatively impact the trajectory of emotional and behavioural difficulties between childhood and adolescence. This paper contributes to current knowledge on the complexities of mental health difficulties in primary school children and their impact on SAPs in early adolescence.
Electrochemical immunosensing of Crohn´s disease biomarkers using diazonium salt grafted - crystalline nanocellulose / carbon nanotubes modified electrodes
Authors: García-Rodrigo Lorena , Ramos-López Claudia , Sánchez-Tirado Esther , Agüí Lourdes , González-Cortés Araceli , Yáñez-Sedeño Paloma , Pingarrón José M. 
Published: October 2024

Abstract

This work reports the first dual immunosensor for the determination of IL-12 and IL-23, two relevant biomarkers of Crohn’s disease (CD). The strategy relies on the selective capture of the targets by the respective antibodies which were covalently immobilized onto SPCEs modified with crystalline nanocellulose (CNC) and multi-walled carbon nanotubes (MWCNTs) followed by conjugation with a detector antibody labelled with poly-HRP-Strept and amperometric transduction using the H2O2/HQ system. The developed bioplatform exhibits a high reproducibility and selectivity allowing the simultaneous determination of both biomarkers using a lower sample volume and lasting a much shorter assay time than those reported for each target with commercially available ELISA kits. It is worth highlighting the storage stability of the bioconjugates, which lasts at least 71 days. This excellent performance is probably due to the combination of the CNC properties, mainly its biocompatibility and hydrophilicity, the high surface area and open pore structure, together with the electrochemical properties of MWCNTs, which provide a nanocomposite excellent for biomolecules immobilization onto the transducer surface and electrochemical detection. The suitability and applicability of the dual immunosensor were demonstrated by analyzing raw serum and faeces spiked with IL-12 and IL-23 at the levels that can be found in samples from patients suffering severe CD.
Suppressing DBNDD2 promotes neuron growth and axon regeneration in adult mammals
Authors: Zhang Lan , Dai WenYu , Wu Yucong , Chen Tianyun , Qian Yuyue , Tang Yiming , Yang Peng , Yi Sheng , Gong Leilei 
Published: October 2024

Abstract

Effective axon regeneration is essential for the successful recovery of nerve functions in patients with axon injury-associated neurological diseases. Certain self-regeneration occurs in injured peripheral axonal branches of dorsal root ganglion (DRG) neurons but does not occur in their central axonal branches. By performing rat sciatic nerve or dorsal root axotomy, we determined the expression of the dysbindin domain containing 2 (DBNDD2) in the DRGs after the regenerative peripheral axon injury or the non-regenerative central axon injury, respectively, and found that DBNDD2 is down-regulated in the DRGs after peripheral axon injury but up-regulated after central axon injury. Moreover, we found that DBNDD2 expression differs in neonatal and adult rat DRGs and is gradually increased during development. DBNDD2 knockdown promotes the outgrowth of neurites in both neonatal and adult rat DRG neurons and stimulates robust axon regeneration in adult rats after sciatic nerve crush injury. Bioinformatic analysis data showed that transcription factor estrogen receptor 1 (ESR1) interacts with DBNDD2, exhibits a similar expression trend as DBNDD2 after axon injury, and may targets DBDNN2. These studies indicate that reduced level of DBNDD2 after peripheral axon injury and low abundance of DBNDD2 in neonates contribute to axon regeneration and thus suggest the manipulation of DBNDD2 expression as a promising therapeutic approach for improving recovery after axon damage.