bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis: Machine vs Human Translation of Educational Scientific Texts. Challenges and Solutions
Authors: Antonova N. A. , Kuzmich I. V. 
Published: September 2024

Introduction. The purpose of this article is to analyze the features of identity formation and identification processes in postmodern society and in digital society. The article explores various approaches to the concept of «identity» within the framework of socio-humanitarian theories. The interrelation of real and virtual identity, the emergence of new forms and models of identity are considered. Two approaches to the analysis of identity in a digital society are analyzed and compared: digital optimism and digital pessimism.Methodology and sources. The article uses a comparative analysis of various theoretical approaches to identity formation. An interdisciplinary approach is used to understand the features of identity in the era of digitalization. As the main sources for the study of the phenomenon of identity there were used works of classics of sociology and psychology E. Erickson, J.G. Meade, E. Durkheim, as well as studies of representatives of modern philosophical and sociological theories Z. Bauman, A. Giddens, S. Turkle, A.A. Lisenkova, T.G. Leshkevich.Results and discussion. It is shown that in postmodern society, identity is characterized by the processes of individualization, fragmentation and the absence of a single cultural center. In a digital society, along with the processes of individualization, there are processes of standardization and unification of person. It is concluded that in a digital society, identity has positive and negative sides. On the one hand, there is a positive vector for the use of online communications, network interaction of people, which destroys spatial and temporal boundaries, as well as social barriers. On the other hand, new types of virtual identity are being formed, challenging a person's own identity.Conclusion. It is concluded that the digital society changes human identity, identification practices and strategies. The consequence of these processes is the formation of a person fused with digital technologies, which leads to the transformation of the social order, social norms and society as a whole.
Lower limb maltorsion and acetabular deformity in children and adolescents with X-linked hypophosphatemia
Authors: Stauffer Alexandra , Raimann Adalbert , Penzkofer Stefan , Ganger Rudolf , Radler Christof , Mindler Gabriel T. 
Published: September 2024

BackgroundX-linked hypophosphatemia (XLH) is a rare monogenetic skeletal disorder. Lower limb deformities contribute substantially to impaired gait quality and burden of disease in patients with XLH. Standardized data regarding onset and severity of lower limb maltorsion are unavailable. This study aimed to evaluate lower limb maltorsion using rotational magnetic resonance imaging (MRI) and computed tomography (CT).MethodsRotational MRI and CT of children and adolescents with verified XLH were evaluated retrospectively. Femoral and tibial torsion, acetabular anteversion, and axial acetabular coverage were measured and compared with published age-adapted radiographic, clinical measurements and MRI data, respectively.ResultsFifteen patients (mean age, 10.7 years) were included in the study. Decreased femoral torsion was observed in 47% (14/30 femora) and femoral retrotorsion in 17% (5/30 femora). Ten of 13 hips with coxa vara deformity presented with decreased femoral antetorsion. Reduced external tibial torsion manifested in 64% (18/28 tibiae). Abnormal axial femoral head coverage was present in 67% (20/30 hips), whereas 53% (16/30 hips) showed increased acetabular anteversion.ConclusionFemoral and tibial torsional pathologies were found in children and adolescents with XLH. The occurrence of severe femoral retrotorsion in a 2-year-old child prior to ambulation raises questions regarding the biomechanical impact of gait on the development of torsional deformities in XLH.
Exploring the causal effects of serum lipids and lipidomes on lewy body dementia: a Mendelian randomization study
Authors: Fu Qingan , Pan Guanrui , Yu Qingyun , Liu Zhekang , Shen Tianzhou , Ma Xiaowei , Jiang Long 
Published: September 2024

BackgroundLewy body dementia (LBD) is a neurodegenerative disorder characterized by the accumulation of Lewy bodies, which primarily composed of misfolded alpha-synuclein (αS). The development of LBD and APOE4 subtypes is thought to be associated with disorders of lipid metabolism. In this study, we investigated the causal relationship between serum lipids, liposomes and LBD using a two-sample Mendelian randomization (TSMR) method.MethodsA TSMR analysis of genome-wide association study (GWAS) data for 8 serum lipids, 179 lipidomes components, LBD and its subtypes was performed, using inverse variance weighted as the primary outcome. To ensure robustness, the sensitivity analyses including MR Pleiotropy RESidual Sum and Outlier, Cochran’s test, leave-one-out method and funnel plots were performed.ResultsIn this study, we found that low-density lipoprotein cholesterol (LDL-C) (OR=1.45, 95% CI=1.19-1.77, P&lt;0.001) and remnant cholesterol (RC) (OR=2.64, 95% CI=1.64-4.28, P&lt;0.001) had significant positive causal effects on LBD, and RC also had a positive effect on LBD in carriers of the APOE4 gene. The results of lipidome analysis showed that phosphatidylcholine (PC) (O-16:0_20:4) levels (OR=0.86, 95% CI=0.75-0.98, P=0.02) and PC (O-18:1_20:4) levels (OR=0.76, 95% CI=0.65-0.89, P &lt;0.001) had negative causal effects on LBD, whereas phosphatidylinositol (PI) (18:1_20:4) levels had a positive causal effect on LBD (OR=1.19, 95% CI=1.02-1.39, P=0.03). For LBD with APOE4 carriers, high levels of PC (16:1_18:0) and PC (O-18:2_18:1) had a significant positive effect, while high levels of PC (O-16:1_18:0), phosphatidylethanolamine (PE) (O-18:2_18:1), sphingomyelin (SM) (d38:2), and triacylglycerol (TAG) (56:5) significantly reduced the risk. No heterogeneity and horizontal pleiotropy were observed in sensitivity analysis.ConclusionElevated LDL-C and RC levels are significant risk factors for LBD, with RC also impacting APOE4-carrying LBD. Glycerophospholipids play a crucial role in the pathogenesis of LBD, but the specific components that play a role differ from those with the APOE4 carries. These findings highlight the importance of lipid metabolism in LBD and APOE4 subtypes.
Driver gene alterations in NSCLC patients in southern China and their correlation with clinicopathologic characteristics
Authors: Deng Lingna , Li Jinbang , Qiu Zhanlong , Wang Yanfen 
Published: September 2024

IntroductionIn this study, we aimed to explore the relationship between clinicopathological features and driver gene changes in Chinese NSCLC patients.MethodsAmplification refractory mutation system PCR was used to detect the aberrations of 10 driver oncogenes in 851 Chinese NSCLC patients, and their correlation with clinicopathological characteristics was also analyzed. Moreover, three models of logistic regression were used to analyze the association between histopathology and EGFR or KRAS mutations.ResultsThe top two most frequently aberrant target oncogenes were EGFR (48.06%) and KRAS (9.51%). These were followed by ALK (5.41%), HER2 (2.35%), MET (2.23%), RET (2.11%), ROS1 (1.88%), BRAF (0.47%), NRAS (0.24%), and PIK3CA (0.12%). Additionally, 11 (1.29%) patients had synchronous gene alterations in two genes. The main EGFR mutations were exon 21 L858R and exon 19-Del, which accounted for 45.97% and 42.79% of all EGFR mutations, respectively. Logistic regression analysis showed that the frequency of EGFR mutations was positively correlated with women, non-smokers, lung adenocarcinoma, and invasive non-mucinous adenocarcinoma (IA), and negatively correlated with solid nodule, micro-invasive adenocarcinoma, and solid-predominant adenocarcinoma. KRAS mutations were positively associated with men and longer tumor long diameters and negatively correlated with lung adenocarcinoma (P &lt; 0.05 for all).ConclusionOur findings suggest that the EGFR mutation frequency was higher in women, non-smokers, lung adenocarcinoma, and the IA subtype in lung adenocarcinoma patients, while the KRAS mutation rate was higher in men and patients with longer tumor long diameter and lower in lung adenocarcinoma patients.
Public e-learning opportunities in anesthesia on YouTube
Authors: Flinspach Armin Niklas , Merk Jana , Raimann Florian Jürgen , Ippolito Angelo , Vo Linda , Blum Lea Valeska , Noone Stephanie , Flinspach Mairen Heumine , Sterz Jasmina , Neef Vanessa 
Published: September 2024

BackgroundThe increasing knowledge in medicine makes continuous education for clinicians necessary more than ever. The range of skills to be covered in anesthesia is constantly growing. How to optimize complex training in practical skills in an increasingly economized environment remains unclear. The extent and suitability to which video platforms assist in learning basic skills in anesthesia has not been investigated yet.MethodsTo identify appropriate videos on YouTube, we conducted a search (May 1st 2023), including common combinations of synonymous terms, and checked up to the 50th result for relevance. Videos initially deemed suitable were archived and evaluated to exclude duplicates. All included videos were subsequently scrutinized for content. For this purpose, a validated checklist to assess procedural and didactic content was used. Data analysis involved assessing interrater reliability, Spearman’s rho test, and linear regression analysis.ResultsWe were able to include 222 videos related to 16 basic skills. The low number of videos found on specific skills was striking. The level of fulfillment illustrating a practical skill was repeatedly found &lt;60%. The consistency of the questionnaire was moderate (Fleiss kappa 0.59). Video runtime displayed a significant correlation (p &lt; 0.001) with the number of items accomplished on procedural (|ρ| = 0.442, R2 = 0.196) and didactic items (|ρ| = 0.452, R2 = 0.153). The professional context of the content creators showed no influence.ConclusionThe quantity of available material on specific basic anesthesiologic skills varied drastically. In addition, the videos available often revealed significant shortcomings, making it challenging to easily assess the quality of the content. The vast majority of evaluated videos did not reflect the intended approach in a scientifically correct manner or were entirely unsuitable for displaying the procedural requirements.
Effects of hemodialysis adequacy on chronic kidney disease complications using latent class trajectory modeling: a real-world study based on long-term observation of Kt/V
Authors: Ai Sanxi , Xu Qiuyu , Chen Gang , Zheng Ke , Qin Yan , Li Xuemei 
Published: September 2024

IntroductionPrevious studies on hemodialysis adequacy primarily focused on the association between Kt/V and survival, and low Kt/V is associated with increased mortality. There is a paucity of research on the correlation between Kt/V and chronic kidney disease (CKD) complications.MethodsThe retrospective study was conducted in the blood purification center of a tertiary hospital in China from July 2020 to September 2022. It aimed to analyze the association between latent Kt/V trajectory categories and CKD complications (hypertension, anemia, mineral and bone disorder) and inflammatory markers. The latent class trajectory model was established to describe the different patterns of Kt/V changes over the observation period.ResultsDuring the 2-year study period, 93 patients on thrice-weekly hemodialysis with residual kidney function &lt;2 mL/min were included. In the 3-class Kt/V trajectory model, 21 patients were in class 1 with a Kt/V trajectory that declined from a higher to lower levels (from &gt;1.6 to &lt;1.4), 59 patients were in class 2 with Kt/V consistently in a relatively low range (around 1.4), and 13 patients were in class 3 with Kt/V stabilized around 1.6. No significant difference in CKD complications or inflammation markers was observed among the three Kt/V trajectories.ConclusionUnder the premise of adequate Kt/V, neither a stable higher Kt/V nor a declined Kt/V significantly influenced CKD complications or inflammatory markers.
Multi-modal remote perception learning for object sensory data
Authors: Almujally Nouf Abdullah , Rafique Adnan Ahmed , Al Mudawi Naif , Alazeb Abdulwahab , Alonazi Mohammed , Algarni Asaad , Jalal Ahmad , Liu Hui 
Published: September 2024

IntroductionWhen it comes to interpreting visual input, intelligent systems make use of contextual scene learning, which significantly improves both resilience and context awareness. The management of enormous amounts of data is a driving force behind the growing interest in computational frameworks, particularly in the context of autonomous cars.MethodThe purpose of this study is to introduce a novel approach known as Deep Fused Networks (DFN), which improves contextual scene comprehension by merging multi-object detection and semantic analysis.ResultsTo enhance accuracy and comprehension in complex situations, DFN makes use of a combination of deep learning and fusion techniques. With a minimum gain of 6.4% in accuracy for the SUN-RGB-D dataset and 3.6% for the NYU-Dv2 dataset.DiscussionFindings demonstrate considerable enhancements in object detection and semantic analysis when compared to the methodologies that are currently being utilized.
Effect of konjac glucomannan on gut microbiota from hyperuricemia subjects in vitro: fermentation characteristics and inhibitory xanthine oxidase activity
Authors: Deng Jie , Zhou Kai , Feng Caimin , Bao Yilu , Zhang Zhiming , Luo Wenfeng , Li Meiying 
Published: September 2024

BackgroundThe disorder of uric acid metabolism is closely associated with gut microbiota and short-chain fatty acids (SCFAs) dysregulation, but the biological mechanism is unclear, limiting the development of uric acid-lowering active polysaccharides. Konjac glucomannan (KGM) could attenuate metabolic disturbance of uric acid and modulate the gut microbiota. However, the relationship between uric acid metabolism and gut microbiota is still unknown.MethodsIn this study, The fecal samples were provided by healthy volunteers and hyperuricemia (HUA) patients. Fecal samples from healthy volunteers was regarded as the NOR group. Similarly, 10% HUA fecal suspension was named as the HUA group. Then, fecal supernatant was inoculated into a growth basal medium containing glucose or KGM, and healthy fecal samples were designated as the NOR-GLU and NOR-KGM groups, while HUA fecal samples were designated as the HUA-GLU and HUA-KGM groups. All samples were cultured in an anaerobic bag system. After fermentation for 24 h, the samples were collected for further analysis of composition of intestinal microbiota, SCFAs concentration and XOD enzyme activity.ResultsThe results showed that KGM could be utilized and degraded by the gut microbiota from HUA subjects, and it could modulate the composition and structure of their HUA gut microbiota to more closely resemble that of a healthy group. In addition, KGM showed a superior modulated effect on HUA gut microbiota by increasing Megasphaera, Faecalibacterium, Lachnoclostridium, Lachnospiraceae, Anaerostipes, and Ruminococcus levels and decreasing Butyricicoccus, Eisenbergiella, and Enterococcus levels. Furthermore, the fermentation solution of KGM showed an inhibitory effect on xanthine oxidase (XOD) enzyme activity, which might be due to metabolites such as SCFAs.ConclusionIn conclusion, the effect of KGM on hyperuricemia subjects was investigated based on the gut microbiota in vitro. In the present study. It was found that KGM could be metabolized into SCFAs by HUA gut microbiota. Furthermore, KGM could modulate the structure of HUA gut microbiota. At the genus level, KGM could decrease the relative abundances of Butyricicoccus, Eisenbergiella, and Enterococcus, while Lachnoclostridium and Lachnospiraceae in HUA gut microbiota were significantly increased by the addition of KGM. The metabolites of gut microbiota, such as SCFAs, might be responsible for the inhibition of XOD activity. Thus, KGM exhibited a superior probiotic function on the HUA gut microbiota, which is expected as a promising candidate for remodeling the HUA gut microbiota.
Sorafenib maintenance after allogeneic stem cell transplantation in patients with FLT3+ AML receiving midostaurin during induction and consolidation: a retrospective analysis
Authors: Sapienza Giuseppe , Castronovo Marta , Tringali Stefania , Bono Roberto , Rotolo Cristina , Mulè Antonino , Calafiore Valeria , Patti Caterina , Agueli Cecilia , Randazzo Valentina , Santoro Alessandra , Matranga Domenica , Castagna Luca 
Published: September 2024

IntroductionAcute myeloid leukemia (AML) relapse is the main cause of death after allogeneic stem cell transplant (allo-SCT). In AML FLT3+, it was shown that Sorafenib used as maintenance therapy after allo-SCT, significantly reduces the risk of relapse and death. MethodsWe analyzed 29 adult patients with FLT3m AML and underwent allogeneic stem cell transplant from 2019 to 2023. All patients received midostaurin plus conventional CT during induction and consolidation. After transplantation, Sorafenib maintenance was administered in all patients independently from MRD status at transplantation. ResultsSorafenib maintenance was applied in 18 patients out 29 patients (62%). Median time to start sorafenib was 100 days (range 37-225) and median duration of treatment was 775 days (range 140-1064). For the whole population (n=29), 2-year OS, LFS, and CIR was 76%, 68% and 28%, respectively. The median time to relapse was 137 days (range 49-246). For patients treated with sorafenib (n=18), the 2-year OS, LFS, and CIR were 94%, 84% and 11%, respectively. For the whole population, the 100-day NRM was 0% and 1-year NRM was 3%. Death was caused by transplant-associated thrombotic microangiopathy in 1 patient. For patients who were administered with Sorafenib, the 1-y NRM was 5%. Death was caused by transplant associated transplant-associated thrombotic microangiopathy. DiscussionThis retrospective study suggests that sorafenib maintenance seem to be effective even in patients pre-treated with midostaurin.
Treatment “non-responders”: the experience of short-term psychoanalytic psychotherapy among depressed adolescents, their parents and therapists
Authors: Fiorini Guilherme , Khoe Zane , Fonagy Peter , Midgley Nick 
Published: September 2024

IntroductionShort-term psychoanalytic psychotherapy (STPP) is an evidence-based treatment for adolescents with depression, but like all treatment approaches, not all patients benefit from it. Previous investigations of the process of STPP have mostly focused on successful cases, and only a few studies have included the perspectives of young people, their parents, and therapists in the understanding of treatment non-response.MethodsSemi-structured interviews were carried out with young people who were considered “non-responders” to STPP, as well as with their parents and therapists. These cases were analyzed using a descriptive-interpretative approach.ResultsThe data analysis revealed three themes: (1) Therapy as a safe space; (2) Can short-term psychotherapy ever be enough?; and (3) Therapists making links and connections that did not make sense to the young people.DiscussionThis study’s findings indicate that “poor outcome” psychotherapy does not necessarily equate to a “poor experience” of psychotherapy, with different stakeholders appreciating the treatment setting as a “safe space.” However, they also suggest that some felt that a relatively short-term treatment could not lead to substantial change and that young people in STPP might have a more negative view of their outcomes compared to their parents and therapists. Finally, the findings indicate that some interventions made by clinicians in STPP feel wrong or do not make sense to young people, potentially affecting the therapy process.
Divergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients
Authors: Chrobak Adrian Andrzej , Bielak Sylwia , Nowaczek Dominik , Żyrkowska Aleksandra , Sobczak Anna Maria , Fafrowicz Magdalena , Bryll Amira , Marek Tadeusz , Dudek Dominika , Siwek Marcin 
Published: September 2024

IntroductionSchizophrenia (SZ) and bipolar disorder (BD) share common clinical features, symptoms, and neurocognitive deficits, which results in common misdiagnosis. Recently, it has been suggested that alterations within brain networks associated with perceptual organization yield potential to distinguish SZ and BD individuals. The aim of our study was to evaluate whether functional connectivity (FC) of the dorsal attention network (DAN) may differentiate both conditionsMethodsThe study involved 90 participants: 30 remitted SZ patients, 30 euthymic BD patients, and 30 healthy controls (HC). Resting state functional magnetic resonance imaging was used to compare the groups in terms of the FC within the core nodes of the DAN involving frontal eye fields (FEF) and intraparietal sulcus (IPS)ResultsBD patients presented weaker inter-hemispheric FC between right and left FEF than HC. While SZ did not differ from HC in terms of inter-FEF connectivity, they presented increased inter- and intra-hemispheric FC between FEF and IPS. When compared with BD, SZ patients showed increased FC between right FEF and other nodes of the network (bilateral IPS and left FEF)ConclusionWe have shown that altered resting state FC within DAN differentiates BD, SZ, and HC groups. Divergent pattern of FC within DAN, consisting of hypoconnectivity in BD and hyperconnectivity in SZ, might yield a candidate biomarker for differential diagnosis between both conditions. More highly powered studies are needed to confirm these possibilities
Collaboration for new therapies: maximizing health and innovation
Authors: Mestre-Ferrandiz Jorge , Meulien Pierre , Ostwald Dennis A. , Acha Virginia 
Published: September 2024

IntroductionInnovative medicines and vaccines can provide direct health benefits to patients and populations by preventing, treating and curing diseases, and also drive wider socioeconomic and productivity gains. However, researching and developing them is complex and risky. Funding for life sciences R&amp;D has different sources: public, charitable/NGO, and private sector. We believe there is consensus that all are required, although there is less understanding about their respective roles, synergies, and funding priorities. The purpose of this paper is to provide an overview of the current life sciences innovation ecosystem in Europe, highlighting challenges for funding and innovation of new therapies and our proposed options to address these.MethodsThe basis of this paper stems from the reflections made by the co-authors during a webinar with title “Collaboration for new therapies: maximising funding and innovation,” in March 2023, with further targeted literature reviews.ResultsWe identify eight challenges in the European life sciences ecosystem, some closely related, and nine options that we think might be helpful to address them. Each option on its own can have different levels of ‘impact’, but collectively will provide synergies among them, and thus maximize their impact.DiscussionIt is critical to ascertain how the strengths of each actor can be leveraged to bring new medicines/treatments to market, quicker and more efficiently. We need a trusted environment, with strategic collaborations between the public and private sectors, and policy initiatives and incentives should be targeted to strengthen the infrastructure with the aim of fostering such optimal alliances.