bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the Phase‐Transfer Catalysis Mechanism of Oxygen Reduction Catalyzed by Iron(III) meso‐tetra‐(4‐N‐Methyl‐pyridyl) Porphine at the Liquid/Liquid Interface
Authors: Huang Xiao , Xuan Yaofang , Xie Lisiqi , Su Bin 
Published: September 2016

AbstractWe report an investigation of the oxygen reduction reaction (ORR) catalyzed by FeIII meso‐tetra‐(4‐N‐methyl‐pyridyl) porphine (FeIIITMPyP) at the polarized water/1,2‐dichloroethane (DCE) interface. FeIIITMPyP is a water soluble pentavalent cation, which has a standard Galvani transfer potential of +0.19 V at the water/DCE interface. By four‐electrode cyclic voltammetry and shake‐flask biphasic reactions controlled by chemical polarization at the macroscale water/DCE interface, we demonstrated that FeIIITMPyP can catalyze the reduction of O2 by electron donors (e.g., ferrocene and 1,1′‐dimethylferrocene). Further, based on voltammetry at the free‐standing silica nanochannel membrane (SNM) supported nano‐ITIES (interface between two immiscible electrolyte solutions) array where the transfer of FeIIITMPyP is physically blocked owing to the size‐exclusion effect, we proved that the overall reaction proceeds through a phase‐transfer catalysis (PTC) process, namely the heterogeneous ion transfer of FeIIITMPyP from water to DCE followed by the homogeneous catalyzed ORR in DCE.
9H‐Quinolino[3,2,1‐k]phenothiazine: A New Electron‐Rich Fragment for Organic Electronics
Authors: Poriel Cyril , Rault‐Berthelot Joëlle , Thiery Sébastien , Quinton Cassandre , Jeannin Olivier , Biapo Urelle , Tondelier Denis , Geffroy Bernard 
Published: September 2016

AbstractA new electron‐rich fragment, namely the quinolinophenothiazine (QPTZ) is reported. The QPTZ fragment incorporated in spiroconfigured materials leads to higher performance in blue Phosphorescent OLEDs than structurally related phenylacridine and indoloacridine based materials (increasing the HOMO energy level, modulating the spin‐orbit coupling, etc.) and leads to highly efficient blue phosphorescent organic light emitting diodes, indicating the strong potential of this new molecular fragment in organic electronics.
Splice form‐dependent regulation of axonal arbor complexity by FMRP
Authors: Zimmer Stephanie E. , Doll Steven G. , Garcia A. Denise R. , Akins Michael R. 
Published: September 2016

ABSTRACTThe autism‐related protein Fragile X mental retardation protein (FMRP) is an RNA binding protein that plays important roles during both nervous system development and experience dependent plasticity. Alternative splicing of the Fmr1 locus gives rise to 12 different FMRP splice forms that differ in the functional and regulatory domains they contain as well as in their expression profile among brain regions and across development. Complete loss of FMRP leads to morphological and functional changes in neurons, including an increase in the size and complexity of the axonal arbor. To investigate the relative contribution of the FMRP splice forms to the regulation of axon morphology, we overexpressed individual splice forms in cultured wild type rat cortical neurons. FMRP overexpression led to a decrease in axonal arbor complexity that suggests that FMRP regulates axon branching. This reduction in complexity was specific to three splice forms—the full‐length splice form 1, the most highly expressed splice form 7, and splice form 9. A focused analysis of splice form 7 revealed that this regulation is independent of RNA binding. Instead this regulation is disrupted by mutations affecting phosphorylation of a conserved serine as well as by mutating the nuclear export sequence. Surprisingly, this mutation in the nuclear export sequence also led to increased localization to the distal axonal arbor. Together, these findings reveal domain‐specific functions of FMRP in the regulation of axonal complexity that may be controlled by differential expression of FMRP splice forms. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 738–752, 2017
Increasing use of nonsurgical therapy in advanced‐stage oral cavity cancer: A population‐based study
Authors: Cannon Richard B. , Sowder Justin C. , Buchmann Luke O. , Hunt Jason P. , Hitchcock Ying J. , Lloyd Shane , Grossman Kenneth F. , Monroe Marcus M. 
Published: September 2016

AbstractBackgroundNational guidelines support surgical‐based treatment and offer nonsurgical therapy as an alternative for advanced‐stage oral cavity squamous cell carcinoma (SCC). There are limited data evaluating current utilization of these therapies and their survival outcomes.MethodsA total of 5856 patients were found in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2008 with resectable advanced‐stage oral cavity SCC tumors. Outcomes were disease‐specific survival (DSS) and overall survival (OS).ResultsSurgical therapy had significantly improved mean DSS and OS (115 and 71 months, respectively) compared to nonsurgical therapy (63 and 35 months, respectively; p < .001). The use of nonsurgical therapy was significantly associated with the hard palate, and patients who were single, divorced, and black, with T3, T4, and N3 tumors, and the percent utilization has significantly increased from 12% to 20% (p < .05).ConclusionUtilization of nonsurgical therapy for advanced‐stage oral cavity SCC is increasing and is independently associated with a reduction in survival, as well as patient factors traditionally associated with reduced access to medical care and advanced T and N classifications. © 2016 Wiley Periodicals, Inc. Head Neck 39: 82–91, 2017
Design and validation of a knowledge map system—the case of construction industry in Taiwan
Authors: Lee kuo‐Wei , Wu Kang‐Li , Kuo Hsing‐Ping , Yuan Pen‐Li 
Published: September 2016

AbstractKnowledge map systems (KMSs) have recently received widespread attention. A review of the literature shows that relatively few studies explicitly address the issues of implementation and user evaluation of the system and are limited in application. In view of this dilemma, this study aims to integrate the key features of knowledge assets maps, knowledge sources maps, knowledge structure maps, and knowledge task maps in order to develop an operational KMS. Also, the technology acceptance model was used as the theoretical basis for the assessment of user acceptance of the system, which is validated using structural equation modeling. In terms of user acceptance assessment, our empirical results shows that the perceived usefulness and perceived ease of use will positively affect user attitude toward the proposed KMS. Also, our results suggest that social defense negatively moderates the effect of attitude toward the system on behavior intention. Furthermore, we found that the management system also positively moderates the effect of attitude toward the system on behavior intention. On the basis of theoretical evaluation and empirical investigation, we hope that the proposed construction of a knowledge system can serve as references for both academic and related practical fields.
Vemurafenib in combination with cobimetinib in relapsed and refractory extramedullary multiple myeloma harboring the BRAF V600E mutation
Authors: Mey Ulrich J.M. , Renner Christoph , von Moos Roger 
Published: September 2016

AbstractBRAF mutations are present in a variety of cancers and cause constitutive activation of the Ras‐Raf–MEK‐ERK signaling pathway. In cutaneous malignant melanoma, combined treatment with BRAF and MEK inhibitors is associated with high response rates and has been shown to improve progression free as well as overall survival compared to BRAF inhibition alone.In multiple myeloma, BRAF mutations are detectable only in a minority of patients. Only few data are available regarding the clinical activity of BRAF inhibitors in BRAF‐positive multiple myeloma patients, including some anecdotal reports on remarkable responses in individuals being resistant to all other available anti‐myeloma treatment approaches.We here present the first report on the combination of vemurafenib and cobimetinib in a young patient with highly resistant and rapidly progressing multiple myeloma harboring the BRAF V600E mutation who achieved a rapid and sustained response to this combination therapy.
“Everybody Knows Your Business”/“Todo Mundo Se Da Cuenta”: Immigrant Adults’ Construction of Privacy, Risk, and Vulnerability in Online Platforms
Authors: Noguerón‐Liu Silvia 
Published: September 2016

AbstractThis article examines immigrant adults’ understandings of privacy, risk, and vulnerability in digital literacy practices that involve visual media. Although the benefits of digital media production have been explored with immigrant youths, the perspectives of adults remain unexplored. Informed by critical and transnational perspectives to digital literacies, ethical guidelines in visual media research, and social constructions of privacy, the author analyzes interactions in technology workshops for Spanish‐dominant, immigrant adults. Findings illustrate how adults’ understandings of online privacy are shaped by simultaneous affiliations to local and transnational networks. Findings also show differences in adults’ distribution, consumption, production, and presence in visual media published in online platforms, as well as their perspectives about participating (or refusing to participate) in these practices. Implications for practitioners implementing technology projects with nondominant and immigrant communities are discussed.
Fabrication of 3D‐culture platform with sandwich architecture for preserving liver‐specific functions of hepatocytes using 3D bioprinter
Authors: Arai Kenichi , Yoshida Toshiko , Okabe Motonori , Goto Mitsuaki , Mir Tanveer Ahmad , Soko Chika , Tsukamoto Yoshinari , Akaike Toshihiro , Nikaido Toshio , Zhou Kaixuan , Nakamura Makoto 
Published: September 2016

AbstractThe development of new three‐dimensional (3D) cell culture system that maintains the physiologically relevant signals of hepatocytes is essential in drug discovery and tissue engineering research. Conventional two‐dimensional (2D) culture yields cell growth, proliferation, and differentiation. However, gene expression and signaling profiles can be different from in vivo environment. Here, we report the fabrication of a 3D culture system using an artificial scaffold and our custom‐made inkjet 3D bioprinter as a new strategy for studying liver‐specific functions of hepatocytes. We built a 3D culture platform for hepatocytes‐attachment and formation of cell monolayer by interacting the galactose chain of galactosylated alginate gel (GA‐gel) with asialoglycoprotein receptor (ASGPR) of hepatocytes. The 3D geometrical arrangement of cells was controlled by using 3D bioprinter, and cell polarity was controlled with the galactosylated hydrogels. The fabricated GA‐gel was able to successfully promote adhesion of hepatocytes. To observe liver‐specific functions and to mimic hepatic cord, an additional parallel layer of hepatocytes was generated using two gel sheets. These results indicated that GA‐gel biomimetic matrices can be used as a 3D culture system that could be effective for the engineering of liver tissues. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1583–1592, 2017.
In vitroand long‐term (2‐year follow‐up)in vivoosteogenic activities of human periosteum‐derived osteoblasts seeded into growth factor‐releasing polycaprolactone/pluronic F127 beads scaffolds
Authors: Lee Jin Ho , Woo Dong Kyun , Kim Tae Ho , Kang Jun Goo , Yun Jeong‐Won , Park Jin‐Ho , Park Bong‐Wook , Kang Young‐Hoon , Rho Gyu‐Jin , Jang Si‐Jung , Park Ji‐Sung , Lee Hee‐Chun , Yoon Young Min , Hwang Tae Sung , Kim Deok Ryong , Hwang Sun‐Chul , Lee Dong Hoon , Kim Ho Young , Oh Se Heang , Byun June‐Ho 
Published: September 2016

AbstractPolycaprolactone (PCL) is a biodegradable polyester that is bioresorbable and biocompatible, and is widely used in medical fields. This study examinesin vitroandin vivoosteogenic activities of cultured human periosteum‐derived osteoblasts (POs) seeded into growth factor (bone morphogenic protein 2 [BMP‐2] or vascular endothelial growth factor [VEGF])‐releasing scaffolds of PCL beads coated with Pluronic F127. Each growth factor immobilized in thePCL/F127is cumulatively released from the beads for more than 40 days (up to 3.04 ± 0.08 ng mg−1BMP‐2 and 3.41 ± 0.18 ng mg−1VEGF in 42 days). Long‐term (∼2 years) experimental results obtained in a miniature pig model suggest that POs seeded into BMP‐2 + VEGF‐releasing PCL/P‐F127 beads are the most effective for bone repair. Inin vitroassays, osteogenic activities were higher in POs seeded into BMP‐2‐releasing PCL/Pluronic F127 beads at earlier time points and in POs seeded into BMP‐2 + VEGF‐releasing PCL/Pluronic F127 beads at later time points. These results suggest that the combination of BMP‐2 and VEGF more sufficiently stimulates (in particular at late time points) osteoblast differentiation of POs seeded in thePCL/F127 in vitroandin vivo,and thus allows effective bone regeneration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 363–376, 2017.
The effects of licorice flavonoid oil with respect to increasing muscle mass: a randomized, double‐blind, placebo‐controlled trial
Authors: Kinoshita Tetsu , Matsumoto Akio , Yoshino Kazuhiro , Furukawa Shinya 
Published: September 2016

AbstractBACKGROUNDThe present study evaluated the effects of licorice flavonoid oil (LFO) with respect to increasing the muscle mass of elderly populations using a randomized, double‐blind, placebo‐controlled study. Fifty participants aged 54–90 years (seven men, 43 women), who underwent rehabilitation treatment for osteoarthritis of the knee, were examined and assigned to either the LFO group (n = 26) or the placebo group (n = 24). The LFO group consumed 300 mg LFO day−1, whereas the placebo group consumed one placebo capsule every day for 16 weeks. We measured muscle mass, body fat percentage and the Japanese Knee Osteoarthritis Measure score at baseline and every 4 weeks thereafter.RESULTSIn the LFO group, muscle mass in the body trunk increased significantly after 16 weeks of LFO intake (+0.38 kg, P = 0.02). The trunk muscle mass weight of the LFO group increased significantly compared to that of the placebo group (P < 0.01). Furthermore, the body fat percentage and body trunk fat percentage of the LFO group were significantly suppressed compared to that of the placebo group (P = 0.03 and P < 0.01, respectively).CONCLUSIONThe results of the present trial indicate that LFO supplementation has effects with respect to increasing muscle mass and suppressing the body fat percentage of elderly populations, especially in the body trunk. © 2016 Society of Chemical Industry
A stabilized extended finite element framework for hydraulic fracturing simulations
Authors: Liu Fushen , Gordon Peter , Meier Holger , Valiveti Dakshina 
Published: September 2016

SummaryWe present a stabilized extended finite element formulation to simulate the hydraulic fracturing process in an elasto‐plastic medium. The fracture propagation process is governed by a cohesive fracture model, where a trilinear traction‐separation law is used to describe normal contact, cohesion and strength softening on the fracture face. Fluid flow inside the fracture channel is governed by the lubrication equation, and the flow rate is related to the fluid pressure gradient by the ‘cubic’ law. Fluid leak off happens only in the normal direction and is assumed to be governed by the Carter's leak‐off model. We propose a ‘local’ U‐P (displacement‐pressure) formulation to discretize the fluid‐solid coupled system, where volume shape functions are used to interpolate the fluid pressure field on the fracture face. The ‘local’ U‐P approach is compatible with the extended finite element framework, and a separate mesh is not required to describe the fluid flow. The coupled system of equations is solved iteratively by the standard Newton‐Raphson method. We identify instability issues associated with the fluid flow inside the fracture channel, and use the polynomial pressure projection method to reduce the pressure oscillations resulting from the instability. Numerical examples demonstrate that the proposed framework is effective in modeling 3D hydraulic fracture propagation. Copyright © 2016 John Wiley & Sons, Ltd.
Elective cholecystectomy reduces morbidity of cholelithiasis in pediatric sickle cell disease
Authors: Goodwin Emily F. , Partain Paige I. , Lebensburger Jeffrey D. , Fineberg Naomi S. , Howard Thomas H. 
Published: September 2016

AbstractBackgroundCholelithiasis is a frequent complication in pediatric sickle cell disease (SCD). Though it is standard practice to perform a cholecystectomy in pediatric SCD patients with symptoms of cholelithiasis, the use of elective cholecystectomy for asymptomatic patients remains controversial.ProcedureRecords of 191 pediatric sickle cell patients with cholelithiasis who underwent cholecystectomy were retrospectively reviewed. Patients classified as follows: (i) elective—no preoperative symptoms, cholelithiasis on screening ultrasound, comprehensive preoperative plan; (ii) symptomatic—preoperative symptoms of cholelithiasis on diagnostic ultrasound, comprehensive preoperative plan; or (iii) emergent—hospitalization for acute cholecystitis symptoms, cholelithiasis on diagnostic ultrasound, limited preoperative preparation. We compared the morbidity of cholecystectomy by examining pre‐ and post‐cholecystectomy hospital admission days, length of stay for cholecystectomy, and surgical complications.ResultsPatients with SCD underwent a total of 191 cholecystectomies over a 10‐year period: 51 elective, 110 symptomatic, and 30 emergent. Patients who required emergent cholecystectomy had a longer postoperative hospitalization time than elective or symptomatic cholecystectomy (7.3 vs 4.3, P < 0.001). Baseline values for total bilirubin and aspartate aminotransferase (AST) were significantly elevated (P < 0.02 and P < 0.07, respectively) in patients requiring emergent cholecystectomy.ConclusionsThis represents the largest reported retrospective review of pediatric cholelithiasis and cholecystectomy in SCD to date. These data strongly suggest that elective cholecystectomy decreases morbidity associated with emergent cholecystectomy. The overall outcomes for symptomatic and elective patients are favorable. However, our study indicates the need for prospective studies to identify clinical indicators for those emergent patients.
A comparison of virtual bronchoscopy versus flexible bronchoscopy in the diagnosis of tracheobronchomalacia in children
Authors: Su Siew Choo , Masters Ian Brent , Buntain Helen , Frawley Kieran , Sarikwal Anubhav , Watson Debbie , Ware Frances , Wuth Jan , Chang Anne Bernadette 
Published: September 2016

SummaryIntroductionFlexible bronchoscopy (FB) is the current gold standard for diagnosing tracheobronchomalacia. However, it is not always feasible and virtual bronchoscopy (VB), acquired from chest multi‐detector CT (MDCT) scan is an alternative diagnostic tool. We determined the sensitivity, specificity, and positive and negative predictive values of VB compared to FB in diagnosing tracheobronchomalacia.MethodsChildren aged <18‐years scheduled for FB and MDCT were recruited. FB and MDCT were undertaken within 30‐min to 7‐days of each other. Tracheobronchomalacia (mild, moderate, severe, very severe) diagnosed on FB were independently scored by two pediatric pulmonologists; VB was independently scored by two pairs (each pair = pediatric pulmonologist and radiologist), in a blinded manner.ResultsIn 53 children (median age = 2.5 years, range 0.8–14.3) evaluated for airway abnormalities, tracheomalacia was detected in 37 (70%) children at FB. Of these, VB detected tracheomalacia in 20 children, with a sensitivity of 54.1% (95%CI 37.1–70.2), specificity = 87.5% (95%CI 60.4–97.8), and positive predictive value = 90.9% (95%CI 69.4–98.4). The agreement between pediatric pulmonologists for diagnosing tracheomalacia by FB was excellent, weighted κ = 0.8 (95%CI 0.64–0.97); but only fair between the pairs of pediatric pulmonologists/radiologists for VB, weighted κ = 0.47 (95%CI 0.23–0.71). There were 42 cases of bronchomalacia detected on FB. VB had a sensitivity = 45.2% (95%CI 30.2–61.2), specificity = 95.5% (95%CI 94.2–96.5), and positive predictive value = 23.2 (95%CI 14.9–34.0) compared to FB in detecting bronchomalacia.ConclusionVB cannot replace FB as the gold standard for detecting tracheobronchomalacia in children. However, VB could be considered as an alternative diagnostic modality in children with symptoms suggestive of tracheobronchomalacia where FB is unavailable. Pediatr Pulmonol. 2017;52:480–486. © 2016 Wiley Periodicals, Inc.
Functional analysis of iodotyrosine deiodinase from drosophila melanogaster
Authors: Phatarphekar Abhishek , Rokita Steven E. 
Published: September 2016

AbstractThe flavoprotein iodotyrosine deiodinase (IYD) was first discovered in mammals through its ability to salvage iodide from mono‐ and diiodotyrosine, the by‐products of thyroid hormone synthesis. Genomic information indicates that invertebrates contain homologous enzymes although their iodide requirements are unknown. The catalytic domain of IYD from Drosophila melanogaster has now been cloned, expressed and characterized to determine the scope of its potential catalytic function as a model for organisms that are not associated with thyroid hormone production. Little discrimination between iodo‐, bromo‐, and chlorotyrosine was detected. Their affinity for IYD ranges from 0.46 to 0.62 μM (Kd) and their efficiency of dehalogenation ranges from 2.4 – 9 x 103 M−1 s−1 (kcat/Km). These values fall within the variations described for IYDs from other organisms for which a physiological function has been confirmed. The relative contribution of three active site residues that coordinate to the amino acid substrates was subsequently determined by mutagenesis of IYD from Drosophila to refine future annotations of genomic and meta‐genomic data for dehalogenation of halotyrosines. Substitution of the active site glutamate to glutamine was most detrimental to catalysis. Alternative substitution of an active site lysine to glutamine affected substrate affinity to the greatest extent but only moderately affected catalytic turnover. Substitution of phenylalanine for an active site tyrosine was least perturbing for binding and catalysis.
Effect of oxygen impurities in semipolar III‐nitride light emitting diodes
Authors: Römer Friedhard , Witzigmann Bernd 
Published: September 2016

AbstractWe investigate the effect of oxygen impurities on the internal quantum efficiency of semipolar III‐nitride light emitting diodes (LED) structures grown along the direction by means of carrier transport simulations. For the model calculations, realistic doping and impurity profiles obtained by secondary ion mass spectroscopy are used. We discuss the impact of the oxygen impurity density on the operation of the LED and the interaction of the donor‐type oxygen impurities with the acceptor doping. It is shown that up to a certain oxygen concentration, no major degradation of the LED efficiency occurs and that with increasing oxygen impurity density the LED efficiency becomes more sensitive to variations of the acceptor doping profile. The independent variation of the oxygen concentration revealed that oxygen impurities are most critical in the electron blocking layer and the p‐side barrier.