bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model
Authors: Chiu Vincent , Yee Christine , Main Nathan , Stevanovski Igor , Watt Matthew , Wilson Trevor , Angus Peter , Roberts Tara , Shackel Nicholas , Herath Chandana 
Published: September 2024

Abstract
Primary liver cancer is an increasing problem worldwide and is associated with significant mortality. A popular method of modeling liver cancer in mice is plasmid hydrodynamic tail vein injection (HTVI). However, plasmid-HTVI models rarely recapitulate the chronic liver injury which precedes the development of most human liver cancer. We sought to investigate how liver injury using thioacetamide contributes to the pathogenesis and progression of liver cancer in two oncogenic plasmid-HTVI-induced mouse liver cancer models. Fourteen-week-old male mice received double-oncogene plasmid-HTVI (SB/AKT/c-Met and SB/AKT/NRas) and then twice-weekly intraperitoneal injections of thioacetamide for 6 weeks. Liver tissue was examined for histopathological changes, including fibrosis and steatosis. Further characterization of fibrosis and inflammation was performed with immunostaining and real-time quantitative PCR. RNA sequencing with pathway analysis was used to explore novel pathways altered in the cancer models. Hepatocellular and cholangiocellular tumors were observed in mice injected with double-oncogene plasmid-HTVI models (SB/AKT/c-Met and SB/AKT/NRas). Thioacetamide induced mild fibrosis and increased alpha smooth muscle actin-expressing cells. However, the combination of plasmids and thioacetamide did not significantly increase tumor size, but increased multiplicity of small neoplastic lesions. Cancer and/or liver injury up-regulated profibrotic and proinflammatory genes while metabolic pathway genes were mostly down-regulated. We conclude that the liver injury microenvironment can interact with liver cancer and alter its presentation. However, the effects on cancer development vary depending on the genetic drivers with differing active oncogenic pathways. Therefore, the choice of plasmid-HTVI model and injury agent may influence the extent to which injury promotes liver cancer development.
Speech-Language Pathologist Self-Efficacy and Job Satisfaction: Resources in Special Education Eligibility Decisions
Authors: Reed Anne C. , Farquharson Kelly 
Published: September 2024

Purpose:
Situated within the conservation of resources theory, this study sought to understand how resources such as self-efficacy, job satisfaction, caseload size, and geographic location influence the number of data sources used by school-based speech-language pathologists (SLPs) to determine eligibility.

Method:
Using a cross-sectional descriptive design, 665 school-based SLPs from the United States reported professional demographics, workload, and assessment/eligibility characteristics, as well as levels of job satisfaction and self-efficacy. Multiple regression was used to examine the effects of self-efficacy, job satisfaction, caseload size, and geographic location on the number of data sources used in eligibility decision making and to examine the effects of caseload size and job satisfaction resources on SLP self-efficacy.

Results:
SLPs, on average, reported using 7.98 data sources to support eligibility determinations. Standardized tests, conversation samples, and review of records were most used, and literacy assessments were used least. Results of multiple regression models indicate that SLPs with higher self-efficacy scores reported using significantly more data sources and that SLPs with higher job satisfaction indicated significantly higher self-efficacy.

Conclusions:
This study affirms self-efficacy as a strong resource for school-based SLPs and that it is, in fact, related to the number of data sources used in eligibility decisions. Limited literacy assessment was reported, despite the SLP's critical role in an educational setting. Job satisfaction as a predictor of self-efficacy and self-efficacy, in turn, as a predictor of data sources underscore the need for SLPs to advocate for work conditions that support their work.
Intrinsically safe DAB converter for reliable power supply in harsh environment via extended phase shift pulse train control
Authors: Xu Yang , Liu Tengfei , Chen Yang , Li Mingxue , Yu Dongsheng , Yu Samson S. 
Published: September 2024

AbstractIn this article, an extended‐phase‐shift‐based pulse train control (EPS‐PT) for an intrinsically safe dual active bridge (DAB) converter is proposed to satisfy the safe and reliable power supply in harsh environments such as gas stations, chemical plants, and mining tunnels in complex power systems. A discrete pulse switching control method is introduced, and the input voltage and output current are sampled to calculate the primary target phase shift angle of the DAB converter, followed by the inner phase shift angle, while the secondary phase shift angle is rapidly adjusted by the voltage feedback. In order to meet the requirements of effective control and safe power supply in harsh environments, the system parameters are designed by comprehensively considering the control performance and intrinsically safe requirements. The simulation and experimental results demonstrate that the proposed DAB converter exhibits rapid dynamic response and intrinsic operation safety.
Enhancing PV receiver efficiency in laser wireless power transmission through square elliptic hyperboloid concentrator
Authors: Xian‐long Meng , Pu Zhang , Yi‐chao Hou , Bei Liu , Ying‐xue Chen , Mallick Tapas K. 
Published: September 2024

AbstractLaser wireless energy transmission is a widely utilized method, yet its efficiency is constrained by a variety of factors. In order to improve the conversion efficiency of the receivers of the laser wireless power transmission (LWPT) system, the square elliptic hyperboloid (SEH) concentrating module designed for LWPT system receivers is developed. By analysing the I–V characteristic curves from the results of the experiments and employing non‐linear parameter regression, a corrected battery characteristic curve was derived within a specific laser irradiation range. On this basis, an optical–thermal–electric multi‐field coupling characteristic model was developed. The finite element method is used to simulate the multi‐field coupling characteristics and conversion efficiency of the receiving end under diverse working conditions (including different rotation angles and different divergence angles) of the concentrating photovoltaic module. Research shows: First, the larger the divergence half‐angle β of the laser beam, the more obvious the improvement of the effective optical efficiency of the system by the SEH concentrator. Second, the short‐circuit current and the maximum output power of the PV cell at the receiving end are significantly improved by the SEH concentrator, and the improvement effect is more obvious with the increase of the divergence angle and the rotation angle. Third, SEH concentrators did not significantly affect the fill factor of PV cells.
Distance estimation of gamma-ray-emitting BL Lac objects from imaging observations
Authors: Nilsson K. , Fallah Ramazani V. , Lindfors E. , Goldoni P. , Becerra González J. , Acosta Pulido J. A. , Clavero R. , Otero-Santos J. , Pursimo T. , Pita S. , Kouch P. M. , Boisson C. , Backes M. , Cotter G. , D’Ammando F. , Kasai E. 
Published: September 2024

Aims. The direct redshift determination of BL Lac objects is highly challenging as the emission in the optical and near-infrared bands is largely dominated by the non-thermal emission from the relativistic jet, which points very close to our line of sight. Therefore, the optical spectra of BL Lac objects often show no spectral lines from the host galaxy. In this work, we aim to overcome this difficulty by attempting to detect the host galaxy and derive redshift constraints based on assumptions on the galaxy magnitude (‘imaging redshifts’).
Methods. Imaging redshifts were derived by obtaining deep optical images under good seeing conditions, making it possible to detect the host galaxy as a weak extension of the point-like source. We then derived the imaging redshift by using the host galaxy as a standard candle, employing two different methods.
Results. We determine the imaging redshift for 9 out of 17 blazars that we observed as part of this programme. The redshift range of these targets is 0.28–0.60, and the two methods used to derive the redshift give very consistent results within the uncertainties. We also performed a detailed comparison of the imaging redshifts with those obtained using other methods, such as direct spectroscopic constraints or looking for groups of galaxies close to the blazar. We show that the constraints from the different methods are consistent and that combining the three constraints narrows down the redshift. For example, in the case of J2156.0+1818, which is the most distant source for which we detect the host galaxy, the redshift range is narrowed to 0.63 < z < 0.71. This makes the source interesting for future studies of extragalactic background light in the Cherenkov Telescope Array Observatory era.
Why heterogeneous cloud particles matter
Authors: Kiefer S. , Samra D. , Lewis D. A. , Schneider A. D. , Min M. , Carone L. , Decin L. , Helling Ch. 
Published: September 2024

Context. The possibility of observing spectral features in exoplanet atmospheres with space missions like the James Webb Space Telescope (JWST) and Atmospheric Remote-sensing Infrared Exoplanet Large-survey (ARIEL) necessitates the accurate modelling of cloud particle opacities. In exoplanet atmospheres, cloud particles can be made from multiple materials and be considerably chemically heterogeneous. Therefore, assumptions on the morphology of cloud particles are required to calculate their opacities.
Aims. The aim of this work is to analyse how different approaches to calculate the opacities of heterogeneous cloud particles affect the optical properties of cloud particles and how this may influence the interpretation of data observed by JWST and future missions.
Methods. We calculated cloud particle optical properties using seven different mixing treatments: four effective medium theories (EMTs; Bruggeman, Landau-Lifshitz-Looyenga (LLL), Maxwell-Garnett, and Linear), core-shell, and two homogeneous cloud particle approximations. We conducted a parameter study using two-component materials to study the mixing behaviour of 21 commonly considered cloud particle materials for exoplanets. To analyse the impact on observations, we studied the transmission spectra of HATS-6b, WASP-39b, WASP-76b, and WASP-107b.
Results. Materials with large refractive indices, like iron-bearing species or carbon, can change the optical properties of cloud particles when they comprise less than 1% of the total particle volume. The mixing treatment of heterogeneous cloud particles also has an observable effect on transmission spectroscopy. Assuming core-shell or homogeneous cloud particles results in less muting of molecular features and retains the cloud spectral features of the individual cloud particle materials. The predicted transit depths for core-shell and homogeneous cloud particle materials are similar for all planets used in this work. If EMTs are used, cloud spectral features are broader and the cloud spectral features of the individual cloud particle materials are not retained. Using LLL leads to fewer molecular features in transmission spectra than when using Bruggeman.
Accretion versus core-filament collision
Authors: Nakamura Fumitaka , Nguyen-Luong Quang , Ishihara Kousuke , Yoshino Aoto 
Published: September 2024

Context. Recent millimetre and sub-millimetre observations have unveiled elongated and asymmetric structures around protostars. These structures, referred to as streamers, often exhibit coherent velocity gradients, seemingly indicating a directed gas flow towards the protostars. However, their origin and role in star formation remain uncertain.
Aims. The protostellar core Per-emb-2, located in Barnard 1, has a relatively large streamer of 104 au that is more prominent in emission from carbon-chain molecules. We aim to unveil the formation mechanism of this streamer.
Methods. We conducted mapping observations towards Per-emb-2 using the Nobeyama 45 m telescope. We targeted carbon-chain molecular lines such as CCS, HC3N, and HC5N at 45 GHz.
Results. Using astrodendro, we identified one protostellar and four starless cores, including three new detections, on the Herschel column density map. The starless and protostellar cores are more or less gravitationally bound. We discovered strong CCS and HC3N emissions extending from the north to the south, appearing to bridge the gap between the protostellar core and the starless core to its north. This bridge spans 3 × 104 au with velocities of 6.5–7.0 km s−1. The velocity gradient of the bridge is opposite that of the streamer. Thus, the streamer is unlikely to be connected to the bridge, suggesting that the former does not have an accretion origin.
Conclusions. We propose that a collision between a spherical core and the filament has shaped the density structure in this region, consequently triggering star formation within the head-tail-shaped core. In this core-filament collision scenario, the collision appears to have fragmented the filament into two structures. The streamer is a bow structure, while the bridge is a remnant of the shock-compressed filament. Thus, we conclude that the Per-emb-2 streamer does not significantly contribute to the mass accumulation towards the protostar.
Erfolgreiche Therapie des systemischen Lupus erythematodes (SLE)
Authors: Oelzner Peter , Wolf Gunter 
Published: September 2024

ZUSAMMENFASSUNGDer systemische Lupus erythematodes (SLE) ist eine multisystemische Autoimmunerkrankung, die prinzipiell alle Organe beziehungsweise Organsysteme betreffen kann. Die initiale Manifestation der Erkrankung kann nach hausärztlicher Überweisung primär zur Vorstellung in nahezu allen Gebieten der Inneren Medizin, aber auch in der Dermatologie oder Neurologie führen. Eine wichtige Voraussetzung für eine zielgerichtete und erfolgreiche Therapie ist die vollständige Erfassung der klinischen Manifestationen, die ein intensives interdisziplinäres Organ-Screening sowohl im Rahmen der initialen Diagnostik als auch der Verlaufskontrolle erfordert. Die Therapie des SLE umfasst neben den alle Patienten betreffenden Basismaßnahmen ebenso eine differenzierte Pharmakotherapie. Diese hängt von den spezifischen Organmanifestationen des einzelnen Patienten ab, darüber hinaus müssen Komorbiditäten und Sicherheitsaspekte berücksichtigt werden. Interdisziplinarität ist daher für eine optimale Betreuung von SLE-Patienten essenziell.
Does the Addition of a Tibial Stem Extender in Total Knee Arthroplasty Decrease Risk of Aseptic Loosening in Patients with Obesity? An Analysis from the American Joint Replacement Registry
Authors: Hohmann Alexandra L. , Linton Alexander A. , Olin Brooke R. , Furey Gabriel L. , Zaniletti Isabella , De Ayushmita , Fillingham Yale A. 
Published: September 2024

AbstractMechanical loosening is a leading cause of failure of total knee arthroplasties (TKAs) for which obesity may be a risk factor. With rising rates of obesity and increasing incidence of TKA, the identification of factors to mitigate this cause of failure is necessary. The purpose of this study is to determine if the use of a tibial stem extender (TSE) decreases the risk of mechanical loosening in patients with obesity undergoing TKA. The American Joint Replacement Registry and linked Centers for Medicare & Medicaid Services claims database were utilized to identify a patient cohort with a body mass index (BMI) of 30 kg/m2 or greater and age 65 years or older who underwent primary elective TKA between 2012 and 2021. Patients were divided into cohorts based on obesity class and TSE utilization. The estimated association of TSE use, BMI categories, and covariates with the risk of revisions for mechanical loosening in both unadjusted and adjusted settings was determined. Hazard ratios and their 95% confidence intervals for the risk of mechanical loosening were calculated. A total of 258,775 TKA cases were identified. A total of 538 of 257,194 (0.21%) patients who did not receive a TSE and one patient out of 1,581 (0.06%) with a TSE were revised for mechanical loosening. In adjusted analysis, TSE use was not protective against mechanical loosening and BMI > 40 was not a significant risk factor. Use of a TSE was not found to be protective against mechanical loosening in patients with obesity; however, analysis was limited by the small number of outcome events in the cohort. Further analysis with a larger cohort of patients with TSE and a longer follow-up time is necessary to corroborate this finding.
Prospective single-arm trial on feasibility and safety of an endoscopic robotic system for colonic endoscopic submucosal dissection
Authors: Chiu Philip W. Y. , Yip Hon Chi , Chu Simon , Chan Shannon M. , Lau Ho Shing Louis , Tang Raymond S.Y. , Phee Soo Jay , Ho Khek Yu , Ng Simon Siu Man 
Published: September 2024

Abstract
Background The development of the EndoMaster “Endoluminal Access Surgical Efficacy” (EASE) system aims to enhance the safety and efficacy of colonic endoscopic submucosal dissection (ESD) through two flexible robotic arms. This is the first clinical trial to evaluate the performance of colorectal ESD using EndoMaster.
Method Patients with early mucosal colorectal neoplasia that was not suitable for en bloc resection with snare-based techniques were recruited. The EndoMaster EASE robotic system consisted of an independently designed flexible robotic platform with two robotic arms. The primary outcome was the complete resection rate using EndoMaster. Secondary outcomes included operating time, hospital stay, procedure-related complications, and oncologic outcomes.
Results 43 patients underwent robotic ESD, with a median robotic dissection time of 49 minutes. The technical success rate was 86.0%, while en bloc resection rate among cases with technical success was 94.6%. The complete resection rate was 83.8% and the median size of specimen was 35 mm (range 15–90 mm). The median hospital stay was 2 (range 1–7) days and there was one delayed bleed after 4 days, which was controlled endoscopically. One patient sustained perforation during the procedure, which was completely closed using clips without sequelae. Two patients were treated by salvage surgery.
Conclusion This first clinical trial confirmed the safety and efficacy of performing colorectal ESD using the EndoMaster EASE robotic system.
Serum Metabolome Signature Response to Different Types of Resistance
Training
Authors: Feuerbacher Joshua Frederik , Cheng Runtan , Sedliak Milan , Hu Min , Finni Taija Juutinen , Umlauff Lisa , Schumann Moritz , Cheng Shulin 
Published: September 2024

AbstractPneumatic resistance training (PRT) facilitates a longer time under tension that
might lead to greater changes in body composition when compared to traditional
resistance training (TRT), possibly enhancing serum metabolite concentrations
indicative of healthy metabolic function. To assess the impact of PRT and TRT on
muscular strength, body composition, and serum metabolome, 69 men (age: 31.8±7.2
years, height: 179.7±5.4 cm, weight: 81.1±9.9 kg) were randomized into two
10-week intervention groups (PRT:n=24 and TRT:n=24) and one control group
(CON:n=21). Serum metabolite concentrations were assessed before and after the
training intervention by high-throughput nuclear magnetic resonance. Fat mass
and lean mass were obtained by bioimpedance analysis. The training intervention
resulted in an increase in lean mass for both PRT (1.85±2.69%; p=0.003) and TRT
(2.72±4.53%; p=0.004), while only PRT reduced statistically significantly in
body fat percentage (PRT: −5.08±10.76%; p=0.019). Only in PRT and TRT
significant increases in small high-density lipoproteins (S-HDL-L) and small HDL
particles (S-HDL-P) were observed. When controlling for fat and lean mass, the
effects on S-HDL-L/S-HDL-P diminished. Network analysis may suggest that PRT and
TRT result in an increase in network connectivity and robustness. It appears
that the observed improvements are associated with changes in body
composition.
Brønsted Acidic Ionic Liquid: An Efficient Organocatalyst for the Synthesis of Pyrrolo[1,2-a]indoles under Neat Conditions
Authors: Majee Adinath , Pramanik Tanmay , Pal Satyajit , Santra Sougata 
Published: September 2024

AbstractA new synthetic approach has emerged for constructing 9H-pyrrolo[1,2-a]indole scaffolds by the reactions between indoles and chalcones under metal- and solvent-free conditions at 80 °C. The reaction occurs smoothly in the presence of a Brønsted acidic ionic liquid, 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium tosylate, as a catalyst, permitting the synthesis of the desired products with satisfactory yields. The developed protocol is applicable to the construction of biologically important pyrrolo[1,2-a]indole derivatives from easily accessible chalcones having various substituents. The process commences with Michael addition to chalcones, followed by annulations induced by the elimination of a water molecule, yielding the 9H-pyrrolo[1,2-a]indole scaffolds. Several control experiments were carried out to achieve a better understanding of the reaction pathway. The feasibility of recycling the catalyst was also demonstrated. This method produces water as the sole byproduct and represents a green synthetic protocol. The clean reaction, easily accessible reactants, and the metal- and solvent-free and environmentally friendly reaction conditions are the notable advantages of this procedure.
Cancer Unveiling: A Profile of Incidence and Trends in Bam City, Southeast Iran
Authors: Jalali Maryam , GHasemi Navid Reza , KHosravi Sajad , Hasani Mahnaz , Nematolahi Samane , Zare Najaf 
Published: September 2024

Background Cancer is one of the leading causes of mortality and morbidity worldwide. According to the report from the Iranian Ministry of Health, cancer ranks as the third most common cause of death in Iran. Consequently, acquiring information about cancer statistics and their trends is crucial for cancer prevention and control. In this study, we examined the trends and epidemiology of cancer in Bam City, Iran, from 2014 to 2019.
Material and Methods This cross-sectional study was conducted using cancer registry data spanning from 2014 to 2019 in Bam, located in Kerman Province. Common cancers were determined based on the reported number of cancer cases and age-standardized rates. Data analysis was performed using SPSS (version 22) and GraphPad Prism (version 9).
Results In this study, we examined 1,290 cases of cancer registered in Bam City, Kerman Province, from 2014 to 2019. Of our study population, 42.8% (552 cases) were women. The sex ratio (male to female) for all cancers during the 6-year study period was 1.34. The highest number of cancer cases among men occurred in 2016, while among women, it was in 2017. The age-standardized incidence rate did not display a clear increasing or decreasing trend; instead, we observed fluctuations over the 6-year period for both sexes. Notably, the age-standardized incidence rate trend for males consistently remained higher than that for females.
Conclusion Fluctuations of the trend in our study can be attributed to reasons such as referral of cases to other cities with better medical facilities and weakness in the cancer registration system of deprived areas such as Bam. Nevertheless, to reduce the burden of cancer, each individual should be aware of the most preventable risk factors, such as an unhealthy lifestyle and occupational exposure. To achieve this goal, the government should prioritize improving the accuracy and completeness of cancer registry centers.