bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A NEW PHOSPHORYLATING AGENT, 2,6‐DICHLOROPHENYL 5‐CHLORO‐8‐QUINOLYL PHOSPHOROCHLORIDATE. ITS APPLICATION IN DEOXYRIBOOLIGONUCLEOTIDE SYNTHESIS BY THE PHOSPHOTRIESTER APPROACH
Authors: TSUCHIYA H. , UEDA S. , KOBAYASHI H. , TAKAKU H. 
Published: May 2016

AbstractDas Phosphorsäureesterdichlorid (I) wird mit dem Chlor‐hydroxy‐chinolin (II) und den geschützten Desoxyribosen (III) zu den Phosphorylierungsagentien (IV) umsetzt.
ChemInform Abstract: ELECTRON TRANSFER‐CATALYZED DIELS‐ALDER REACTIONS OF ELECTRON‐RICH DIENOPHILES UNDER PHOTOCHEMICAL INITIATION
Authors: MLCOCH J. , STECKHAN E. 
Published: May 2016

AbstractDiels‐Alder‐Reaktionen lassen sich über einen Elektronentransfer‐Kettenmechanismus katalysieren.
ChemInform Abstract: SMALL RINGS. PART 56. CARROUSEL REARRANGEMENT IN THE 1,2,3,4‐TETRA‐TERT‐BUTYLHYDROXYCYCLOBUTENYLIUM ION
Authors: MAIER G. , EMRICH R. , KALINOWSKI H.‐O. 
Published: May 2016

AbstractBei der oxidativen Ringöffnung des Tetrahedrans (I) entstehen Cyclobutenylium‐Salze, für deren Kation aufgrund der Temp.‐Abhängigkeit der 1H‐ und 13C‐NMR‐Spektren ein Gleichgewicht zwischen (II) z: (III) 2 (IV) postuliert wird.
ChemInform Abstract: REACTIONS OF IMIDOYL CHLORIDES WITH SILVER NITRITE AND SILVER NITRATE. A SIMPLE SYNTHESIS OF N‐NITROSO AND N‐NITRO AMIDES USING IMIDATE ESTER METHODOLOGY
Authors: DE CARVALHO E. , NORBERTO F. , ROSA E. , ILEY J. , PATEL P. 
Published: May 2016

AbstractDie Titelreaktion wird als neues Verfahren zur Darstellung nitrosierter bzw. nitrierter Amide vorgestellt.
ChemInform Abstract: HALOGEN ABSTRACTION BY TRIPHENYLPHOSPHINE OF PERFLUORODIAZADICHLOROALKANES CONTAINING N‐CCL2‐N GROUPS. X‐RAY STRUCTURE ANALYSIS OF PERFLUORO‐2,3,5,6‐TETRAKIS(DIMETHYLAMINO)PYRAZINE
Authors: BRAUER D. J. , BUERGER H. + , PAWELKE G. 
Published: May 2016

AbstractDie Umsetzung des Imidazolidin‐Derivates (III) mit Triphenylphosphin (II) liefert das bicyclische Olefin (I), in Gegenwart von Wasser entsteht dagegen das Imidazolidin (IV).
ChemInform Abstract: MERCURIC ACETATE CYCLIZATION OF 4‐(ARYLMETHYL)PIPERIDINES: SYNTHESIS OF INDOLO(2,3‐G)MORPHANS (TETRACYCLIC RING SYSTEM OF STRYCHNOS INDOLE ALKALOIDS) AND 7,8‐BENZOMORPHANS
Authors: BOSCH J. , BONJOCH J. , DIEZ A. , LINARES A. , MORAL M. , RUBIRALTA M. 
Published: May 2016

AbstractWährend in der Indolreihe eine glatte Cyclisierung der Vorstufen (VI) [Darstellung gemäß Formelschema aus (I)] zu den Zielverbindungen (VII) erfolgt, beeinflussen die Substituenten von Arylpiperidinen maßgeblich den Verlauf der Hg(OAc)2‐Oxidation.
ChemInform Abstract: PERFLUOROORGANOCADMIUM COMPOUNDS AS VERY EFFICIENT PERFLUOROALKYLATION AND PERFLUOROPHENYLATION AGENTS FOR PREPARATION OF PERFLUOROORGANOTIN AND ‐LEAD COMPOUNDS
Authors: LANGE H. , NAUMANN D. 
Published: May 2016

AbstractDurch die Umsetzung der Perfluororgano‐Cadmium‐Derivate (I) mit Trimethylzinn‐ bzw. ‐bleitrifluoracetat (II) erhält man die Organozinn‐ bzw. ‐blei‐ Verbindungen (III) neben dem Acetat (IV).
ChemInform Abstract: Red Form of Bis(1,10‐phenanthroline)dithiocyanatoiron(II).
Authors: SAVAGE S. , ZHOU J.‐L. , MADDOCK A. G. 
Published: May 2016

AbstractDie Neuuntersuchung mittels IR‐, 1H‐NMR‐ und Mößbauer‐spektroskopischer Untersuchungen sowie magnetischer und Leitfähigkeitsmessungen der nach Schilt in wäßriger Lösung dargestellten Titelverbindung ergibt ihre Formulierung als (I).
ChemInform Abstract: MIXED‐LIGAND COMPLEXES OF COBALT(III) WITH PHENANTHROLINE AND PICOLINIC ACID. PREPARATION, CHARACTERIZATION, AND SOME PHOTOCHEMICAL PROPERTIES
Authors: PAVLOVSKII V. I. , POZNYAK A. L. 
Published: May 2016

AbstractDie aus Co(II)‐chlorid, Picolinsäure und Phenanthrolin bei anschließender Oxidation durch PbO2 und Luft‐O, gebildeten Komplexe (I), (II) und (III) werden über Ionenaustauscher als Perchlorate isoliert; die Trennung der Isomeren (II) und (III) erfolgt durch fraktionierte Kristallisation.
ChemInform Abstract: PHOTOCYCLIZATION OF ENAMIDES. PART 24. TOTAL SYNTHESIS OF (.+‐.)‐ISOFUMIGACLAVINE B AND (.+‐.)‐LYSERGIC ACID
Authors: NINOMIYA I. , HASHIMOTO C. , KIGUCHI T. , NAITO T. 
Published: May 2016

AbstractDurch reduktive Photocyclisierung des Amids (IV) erhält man ein Diastereomerengemisch der Pentacyclen (V); das Hauptprodukt (Va) wird anschließend in die cis‐Diole (VIII) (3 :2‐Gemisch ungewisser Zuordnung) gibergeführt.
ChemInform Abstract: REACTIONS AT SILICON CENTERS BEARING THE BULKY TRIS(PHENYLDIMETHYLSILYL)METHYL LIGAND
Authors: EABORN C. , MANSOUR A. I. 
Published: May 2016

AbstractMetallierung der Si‐Verbindung (I) und nachfolgende Substitutionsreaktion geben die Derivate (IV) bzw. (V) (mit einer Reihe von anderen Organosiliciumverbindungen wie z.B. Trimethylsilylchlorid erfolgen jedoch keine Reaktionen); aus (Vb) sind weiter die Halogenderivate (VIa)‐(VIc) zugänglich, von denen (VIa) mit verschiedenen Reagentien wie im Formelschema aufgeführt unter Bildung von Verbindungen (VId)‐(VIj) bzw. (VIII) umgesetzt werden.
ChemInform Abstract: SYNTHESIS AND REACTIONS OF HYDRIDO(η1‐ALLYL)‐ AND HYDRIDO(η3‐ALLYL)IRIDIUM COMPLEXES
Authors: MCGHEE W. D. , BERGMAN R. G. 
Published: May 2016

AbstractDer Versuch, den aus [η5‐C5Me5IrCl2]2 und Allyl‐MgCl synthetisierten Chloro‐η3‐allyl‐Komplex (I) durch sukzessive Umsetzung mit Trimethylphosphin und Hydrid in das Phosphin‐substituierte η1‐Allylhydrid (VI) überzuführen, bleibt erfolglos.
ChemInform Abstract: SYNTHESIS OF THE RIBOSIDE ANALOG OF THE PYRIMIDINE ADDUCT FORMED IN THE REACTION BETWEEN THE CARCINOGEN N‐HYDROXY‐N‐2‐ACETYLAMINOFLUORENE AND DNA
Authors: ROBILLARD B. , LHOMME M. F. , LHOMME J. 
Published: May 2016

AbstractDie Synthese des Ribosids (VI).
ChemInform Abstract: 3H‐AZEPINES AND RELATED SYSTEMS. PART 3. MONO‐ AND BIS‐2‐ALKOXY‐3H‐AZEPINE‐3‐CARBOXYLATES AND ‐3‐CARBOXAMIDES BY PHOTOLYSIS OF MONO‐ AND DI‐O‐AZIDOBENZOYL DERIVATIVES OF GLYCOLS AND DIAMINES. SOME ACYCLIC CROWN ETHER ANALOGS
Authors: AZADI‐ARDAKANI M. , SALEM S. M. , SMALLEY R. K. , PATEL D. I. 
Published: May 2016

AbstractDie im Formelschema aufgeführten o‐Azidobenzoesäurederivate [(IVb) und (IVc) reagieren im Gegensatz zu (IVa) nur zu Harzen] werden in Gegenwart von Alkoholen bestrahlt.
Biarylalkyl Carboxylic Acid Derivatives as Novel Antischistosomal Agents
Authors: Mäder Patrick , Blohm Ariane S. , Quack Thomas , Lange‐Grünweller Kerstin , Grünweller Arnold , Hartmann Roland K. , Grevelding Christoph G. , Schlitzer Martin 
Published: May 2016

AbstractParasitic platyhelminths are responsible for serious infectious diseases, such as schistosomiasis, which affect humans as well as animals across vast regions of the world. The drug arsenal available for the treatment of these diseases is limited; for example, praziquantel is the only drug currently used to treat ≥240 million people each year infected with Schistosoma spp., and there is justified concern about the emergence of drug resistance. In this study, we screened biarylalkyl carboxylic acid derivatives for their antischistosomal activity against S. mansoni. These compounds showed significant influence on egg production, pairing stability, and vitality. Tegumental lesions or gut dilatation was also observed. Substitution of the terminal phenyl residue in the biaryl scaffold with a 3‐hydroxy moiety and derivatization of the terminal carboxylic acid scaffold with carboxamides yielded compounds that displayed significant antischistosomal activity at concentrations as low as 10 μm with satisfying cytotoxicity values. The present study provides detailed insight into the structure–activity relationships of biarylalkyl carboxylic acid derivatives and thereby paves the way for a new drug‐hit moiety for fighting schistosomiasis.
Fine‐needle aspiration of soft tissue perineurioma: A comparative analysis of cytomorphology and immunohistochemistry with benign and malignant mimics
Authors: Yang Eric J. , Hornick Jason L. , Qian Xiaohua 
Published: May 2016

AbstractBACKGROUNDSoft tissue perineurioma (STP) is a benign peripheral nerve sheath tumor demonstrating uniform perineurial cell differentiation. To the authors' knowledge, the cytomorphologic features of STP remain incompletely characterized, and the distinction between STP and its benign (intramuscular/cellular myxoma) and malignant (low‐grade fibromyxoid sarcoma [LGFMS]) mimics is challenging.METHODSFine‐needle aspiration (FNA)/core needle biopsies of 25 low‐grade myxoid spindle cell neoplasm cases including STP (5 cases), intramuscular/cellular myxoma (16 cases), and LGFMS (4 cases) were reviewed retrospectively for cytomorphologic and immunophenotypic comparison.RESULTSFNA smears of STP were hypocellular with scattered clusters of spindle cells with bland, slender nuclei; bipolar cytoplasmic processes; and scant myxoid to collagenous matrix. STP commonly lacked the abundant granular myxoid matrix material present in intramuscular/cellular myxoma (20% in STP vs 75% in intramuscular/cellular myxoma; P <.05), but these tumors were otherwise remarkably found to be similar on FNA smears. All STP and intramuscular/cellular myxoma cases lacked cytologic atypia, whereas 50% of LGFMS cases demonstrated mild nuclear atypia. EMA was positive in all STPs, but also was found to be at least focally positive in 60% of intramuscular/cellular myxoma cases (9 of 15 cases) and 75% of LGFMS cases (3 of 4 cases). MUC4 was found to be negative in all 15 intramuscular/cellular myxoma and 5 STP cases, but was positive in all 4 LGFMS cases.CONCLUSIONSSTP, intramuscular/cellular myxoma, and LGFMS have significant cytomorphologic overlap. Immunohistochemical staining with EMA is not beneficial due to a lack of specificity. Negative MUC4 staining reliably excludes LGFMS. Therefore, a clinically meaningful approach to the FNA biopsy evaluation of a low‐grade myxoid spindle cell neoplasm is to provide a differential diagnosis and to exclude a low‐grade sarcoma. Cancer Cytopathol 2016;124:651–8. © 2016 American Cancer Society.
Patient‐specific parameter estimation in single‐ventricle lumped circulation models under uncertainty
Authors: Schiavazzi Daniele E. , Baretta Alessia , Pennati Giancarlo , Hsia Tain‐Yen , Marsden Alison L. 
Published: May 2016

SummaryComputational models of cardiovascular physiology can inform clinical decision‐making, providing a physically consistent framework to assess vascular pressures and flow distributions, and aiding in treatment planning. In particular, lumped parameter network (LPN) models that make an analogy to electrical circuits offer a fast and surprisingly realistic method to reproduce the circulatory physiology. The complexity of LPN models can vary significantly to account, for example, for cardiac and valve function, respiration, autoregulation, and time‐dependent hemodynamics. More complex models provide insight into detailed physiological mechanisms, but their utility is maximized if one can quickly identify patient specific parameters. The clinical utility of LPN models with many parameters will be greatly enhanced by automated parameter identification, particularly if parameter tuning can match non‐invasively obtained clinical data. We present a framework for automated tuning of 0D lumped model parameters to match clinical data. We demonstrate the utility of this framework through application to single ventricle pediatric patients with Norwood physiology. Through a combination of local identifiability, Bayesian estimation and maximum a posteriori simplex optimization, we show the ability to automatically determine physiologically consistent point estimates of the parameters and to quantify uncertainty induced by errors and assumptions in the collected clinical data. We show that multi‐level estimation, that is, updating the parameter prior information through sub‐model analysis, can lead to a significant reduction in the parameter marginal posterior variance. We first consider virtual patient conditions, with clinical targets generated through model solutions, and second application to a cohort of four single‐ventricle patients with Norwood physiology. Copyright © 2016 John Wiley & Sons, Ltd.
Catalytic Coupling of Carbon Dioxide with Terpene Scaffolds: Access to Challenging Bio‐Based Organic Carbonates
Authors: Fiorani Giulia , Stuck Moritz , Martín Carmen , Belmonte Marta Martínez , Martin Eddy , Escudero‐Adán Eduardo C. , Kleij Arjan W. 
Published: May 2016

AbstractThe challenging coupling of highly substituted terpene oxides and carbon dioxide into bio‐based cyclic organic carbonates catalyzed by Al(aminotriphenolate) complexes is reported. Both acyclic as well as cyclic terpene oxides were used as coupling partners, showing distinct reactivity/selectivity behavior. Whereas cyclic terpene oxides showed excellent chemoselectivity towards the organic carbonate product, acyclic substrates exhibited poorer selectivities owing to concomitant epoxide rearrangement reactions and the formation of undesired oligo/polyether side products. Considering the challenging nature of these coupling reactions, the isolated yields of the targeted bio‐carbonates are reasonable and in most cases in the range 50–60 %. The first crystal structures of tri‐substituted terpene based cyclic carbonates are reported and their stereoconnectivity suggests that their formation proceeds through a double inversion pathway.
Effects of transcranial direct current stimulation (tDCS) on binge‐eating disorder
Authors: Burgess Emilee E. , Sylvester Maria D. , Morse Kathryn E. , Amthor Frank R. , Mrug Sylvie , Lokken Kristine L. , Osborn Mary K. , Soleymani Taraneh , Boggiano Mary M. 
Published: May 2016

ABSTRACTObjectiveTo investigate the effect of transcranial direct current stimulation (tDCS) on food craving, intake, binge eating desire, and binge eating frequency in individuals with binge eating disorder (BED).MethodN = 30 adults with BED or subthreshold BED received a 20‐min 2 milliampere (mA) session of tDCS targeting the dorsolateral prefrontal cortex (DLPFC; anode right/cathode left) and a sham session. Food image ratings assessed food craving, a laboratory eating test assessed food intake, and an electronic diary recorded binge variables.ResultstDCS versus sham decreased craving for sweets, savory proteins, and an all‐foods category, with strongest reductions in men (p < 0.05). tDCS also decreased total and preferred food intake by 11 and 17.5%, regardless of sex (p < 0.05), and reduced desire to binge eat in men on the day of real tDCS administration (p < 0.05). The reductions in craving and food intake were predicted by eating less frequently for reward motives, and greater intent to restrict calories, respectively.DiscussionThis proof of concept study is the first to find ameliorating effects of tDCS in BED. Stimulation of the right DLPFC suggests that enhanced cognitive control and/or decreased need for reward may be possible functional mechanisms. The results support investigation of repeated tDCS as a safe and noninvasive treatment adjunct for BED. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2016; 49:930–936)
On the electromigration of charged fluorophore‐labeled oligosaccharides in polyethylene oxide solutions
Authors: Jarvas Gabor , Kerekgyarto Marta , Guttman András 
Published: May 2016

The separation mechanism of charged fluorophore (aminopyrenetrisulfonate)‐labeled maltooligosaccharides with α1‐4 linkages was studied in polyethylene oxide (PEO) solutions (MW 300 000 Da) with special interest to possible analyte and/or network deformations as well as potential solute–matrix interactions. The electrophoretic mobilities of the 8‐aminopyrene‐1,3,6‐trisulfonate‐labeled maltooligosaccharides were found proportional with their MW−2/3. The Arrhenius function was used to determine the activation energy needed by the labeled sugars to migrate through the separation media. With increasing solute size, the activation energy (Ea) values decreased in polymer concentrations above the entanglement threshold of the PEO, while showed apparently independent function at the entanglement threshold. The observed phenomenon was considered as a result of solute–matrix interaction, which could be alleviated by the addition of an organic modifier to the BGE.
Electrochemically triggered aptamer immobilization via click reaction for vascular endothelial growth factor detection
Authors: Feng Lingyan , Lyu Zhaozi , Offenhäusser Andreas , Mayer Dirk 
Published: May 2016

The vascular endothelial growth factor 165 (VEGF165) is widely used as an important biomarker in cancer‐ and neuron‐related diseases. Herein, an aptamer‐based biosensor is developed that features effective protein detection. A DNA aptamer is immobilized on a gold electrode surface as recognition element utilizing an electrochemically triggered click reaction. By adjusting the applied cathodic potential, the copper catalyst can be in‐situ generated and induce a [3 + 2] cycloaddition reaction between the alkyne‐modified aptamer and the azide‐functionalized electrode surface. Compared to the commonly used thiol‐based aptamer immobilization, the present strategy facilitates a high surface probe density to (1.6 ± 0.12) × 1012 molecules/cm2 in a short period (30 min), long‐time stability (at least 1 month), as well as regenerative detection performance with an 84% current recovery in each regeneration cycle. Our work reports on a versatile strategy for the fabrication of VEGF165 aptamer‐based biosensors, which can be transferred to other aptamer‐based sensors and provides an alternative route for the immobilization of aptamer molecules to sensor surfaces.
Typing and surface charges of the variable loop regions of PorB from Neisseria meningitidis
Authors: Stefanelli Paola , Neri Arianna , Tanabe Mikio , Fazio Cecilia , Massari Paola 
Published: May 2016

AbstractPorB is a pan‐Neisserial major outer membrane protein with a trimeric β‐barrel structure. Each monomer presents eight periplasmic turns and eight surface exposed loop regions with sequence variability. PorB induces activation of host cell responses via a TLR2‐dependent mechanism likely mediated by electrostatic interactions between TLR2 and PorB surface exposed loops. Variability in the loop amino acid sequence is known to influence cell responses to PorB in vitro, particularly for the residues in L5 and L7. In this work, the sequence of the porB gene and the electrostatic surface charges of PorB from 35 invasive meningococcal isolates belonging to the main clonal complexes identified in Italy and from five carriage genomes available on the website http://pubmlst.org/neisseria/ were examined. Analysis of the porB encoding regions from the invasive meningococci has identified four new alleles and a potential association between porB alleles, serogroup, and clonal complexes. Through computer‐based modeling and analysis of the electrostatic surface charges of PorB from these strains, loop charge segregation between PorB from invasive serogroups B and C was observed. Specifically, loops 1, 4, and 7 were negatively charged and L2 and L8 were mostly neutral in serogroup B isolates, while an overall homogeneous positive surface charge was present in PorB from invasive serogroup C strains. A higher PorB sequence variability was observed among carriage genomes, and a general prevalence of negative loop surface charges. The surface charge differences in PorB from serogroups B and C invasive and carriage strains may, in part, influence the outcomes of Neisseriae interactions with host cells. © 2016 IUBMB Life, 68(6):488–495, 2016
Symptomatic presentation as a predictor of recurrence in gastroenteropancreatic neuroendocrine tumors: A single institution experience over 15 years
Authors: Baptiste Gillian G. , Postlewait Lauren M. , Ethun Cecilia G. , Le Nina , McInnis Mia R. , Russell Maria C. , Winer Joshua H. , Kooby David A. , Staley Charles A. , Maithel Shishir K. , Cardona Kenneth 
Published: May 2016

Background and ObjectivesThe prognostic implication of symptomatic presentation of gastroenteropancreatic neuroendocrine tumors (GEP‐NETs) remains unclear.MethodsPatients who underwent resection of nonfunctional GEP‐NETs (2000–2014) were analyzed. Primary outcomes were overall survival (OS) and distant recurrence‐free survival (RFS).ResultsSymptomatic presentation was seen in 208 (61%) of 339 patients and was associated with younger age (55 vs. 59 yrs, P = 0.001), higher tumor grade (38% vs. 21%, P = 0.027), presence of lymphovascular invasion (58% vs. 33%, P < 0.001), presence of perineural invasion (54% vs. 29%, P = 0.002), and advanced disease (T3/T4/N1/M1 [63% vs. 44%, P = 0.002]), but not tumor size (2.6 vs. 2.5 cm, P = 0.74). Symptomatic presentation was associated with decreased 3‐yr distant‐RFS (80% vs. 89%, P = 0.012), but not OS. When accounting for adverse features, symptomatic presentation remained independently associated with reduced distant‐RFS (HR 3.51, P = 0.007). On subgroup‐analysis of advanced disease patients, symptomatology was associated with reduced 3‐yr distant‐RFS (67% vs. 79%, P = 0.012) and persisted as an independent risk‐factor for decreased distant‐RFS (HR 3.01, P = 0.027).ConclusionsSymptomatic presentation of GEP‐NETs is associated with aggressive features and worse distant‐RFS. Trials assessing adjuvant therapy for advanced GEP‐NETs are needed, and symptomatic presentation may be considered as one inclusion criterion. Following resection, symptomatic presentation should be taken into account when planning surveillance. J. Surg. Oncol. 2016;114:163–169. © 2016 Wiley Periodicals, Inc.
Ocean Acidification ‐ A Paleo Perspective
Authors: Paytan Adina , Hönisch Bärbel 
Published: May 2016

Dissolution of atmospheric CO2 in seawater has lowered ocean pH and carbonate ion concentrations with impacts on marine organisms and ecosystems. The geological record contains long‐term evidence for a variety of global environmental perturbations, including ocean acidification, and the biotic responses associated with them, and can provide insight into consequences of current anthropogenic acidification. This e‐lecture focuses on the paleo‐perspective of ocean acidification, proxy evidence for pH changes and several events exhibiting evidence for elevated atmospheric CO2, global warming, and ocean acidification over the past ˜300 million years are reviewed. Comparison between these events and the present suggests that the current and projected rate of acidification may be unprecedented in past events with unknown consequences for marine life and humans who depend on it.The target audiences for this e‐Lecture are upper division undergraduate students and graduate students with some previous background in oceanography and paleoceanography. This could be a lecture in an “introduction to paleoceanography” class that discusses archives and proxies or a lecture in a topical “ocean acidification” class covering paleo ocean acidification. Depending on audience background the lecture may take 50 minutes (students versed in paleoceanography) or 90 minutes (novice students).