bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk for metabolic diseases in normal weight individuals with visceral fat accumulation: a cross-sectional study in Japan
Authors: Tatsumi Yukako , Nakao Yoko M , Masuda Izuru , Higashiyama Aya , Takegami Misa , Nishimura Kunihiro , Watanabe Makoto , Ohkubo Takayoshi , Okamura Tomonori , Miyamoto Yoshihiro 
Published: January 2017

ObjectiveTo investigate the association between visceral fat area (VFA) and metabolic syndrome (Mets) among normal weight Japanese.DesignA cross-sectional study.SettingThe health check-up centre of the Takeda Hospital group in Kyoto, Japan.MethodsThis study involved 1674 men and 1448 women aged 30–74 years who underwent medical check-ups in 2012 in the health check-up centre. They were stratified by Body Mass Index (BMI cut-off for obesity is set at 23.0 kg/m2for Asians): normal weight 18.5–22.9 kg/m2or higher weight ≥23.0 kg/m2. The age-adjusted ORs of the 2nd to 4th groups of sex-specific VFA quartiles compared with the 1st quartile for a Mets component clustering were estimated. The clustering was having two or more of the following factors: high blood pressure, high fasting blood glucose (FBG), low high-density lipoprotein cholesterol (HDL-C) and high triglycerides. Statistical analyses were conducted in 2016.ResultsParticipants in the 2nd to 4th VFA quartiles had significantly higher clustering risks; ORs were 3.4 (1.5 to 8.0), 6.3 (2.8 to 14.2) and 9.3 (4.2 to 20.7) for normal weight participants, and 1.7 (1.2 to 2.6), 2.6 (1.8 to 3.9) and 6.0 (4.1 to 8.8) for higher weight participants, respectively. The ORs of the 4th VFA quartile for Mets components were significantly higher; ORs for normal weight participants were 2.1 (1.5 to 3.0) (high blood pressure), 2.4 (1.4 to 4.2) (high FBG), 5.2 (2.1 to 12.9) (low HDL-C) and 12.0 (5.7 to 25.3) (high triglycerides), and higher weight participants were 3.9 (2.8 to 5.5), 4.1 (2.8 to 6.2), 3.9 (2.2 to 6.9) and 5.0 (3.4 to 7.4), respectively.ConclusionsAmong participants with normal weight, as well as those of higher weight, dose-dependent responses were observed between VFA and risk for Mets components and the clustering among Japanese adults. VFA may be useful information for interventions to improve metabolic risk factors in people with normal weight.
National estimation of children in residential care institutions in Cambodia: a modelling study
Authors: Stark Lindsay , Rubenstein Beth L , Pak Kimchoeun , Kosal Sok 
Published: January 2017

ObjectivesThe primary objective of this study was to collect baseline data on the number of children living in residential care institutions in Cambodia. The secondary objective was to describe the characteristics of the children (eg, age, sex, duration of stay, education and health). The data were intended to guide recent efforts by the Government of Cambodia to reduce the number of children living in residential care institutions and increase the number of children growing up in supportive family environments.SettingData were collected in Cambodia across 24 sites at the commune level. Communes—administrative divisions roughly equivalent to counties—were selected by the National Institute of Statistics using a two-stage sampling method.DesignGovernment lists and key informant interviews were used to construct a complete roster of institutions across the 24 communes. All identified institutions were visited to count the number of children and gather data on their basic characteristics. The rate of children in residential care in the selected communes was calculated as a percentage of total population using a Poisson model. This rate was applied to all districts in Cambodia with at least one reported residential care institution.ParticipantsA total of 3588 children were counted across 122 institutions. A child living in a residential care institution was defined as anyone under the age of 18 years who was sleeping in the institution for at least four nights per week during the data collection period.ResultsThere are an estimated 48 775 children living in residential care institutions in Cambodia. The vast majority of children have a living parent and are school-aged. More than half are between 13 and 17 years of age.ConclusionsNearly 1 of every 100 children in Cambodia is living in residential care. This raises substantial concerns for child health, protection and national development.
Cross-sectional, descriptive study of Chagas disease among citizens of Bolivian origin living in Munich, Germany
Authors: Navarro Miriam , Berens-Riha Nicole , Hohnerlein Stefan , Seiringer Peter , von Saldern Charlotte , Garcia Sarah , Blasco-Hernández Teresa , Navaza Bárbara , Shock Jonathan , Bretzel Gisela , Hoelscher Michael , Löscher Thomas , Albajar-Viñas Pedro , Pritsch Michael 
Published: January 2017

PurposeChagas disease (CD) has become a global health issue mainly due to migration. Germany lacks surveillance data and is home to a large Latin American immigrant population. Recognising that Bolivia is the country with the highest CD prevalence in Latin America, this cross-sectional, descriptive pilot study investigated CD and associated factors among citizens of Bolivian origin living in Munich, Germany.MethodsParticipants completed a questionnaire in order to collect socioeconomic and health-related data. In addition, serology was performed. In case of positive serological tests, PCR diagnostic and clinical staging together with disease management was initiated. Qualitative research was conducted to identify personal and community barriers as well as strategies to increase CD awareness among the population at risk.ResultsBetween June 2013 and June 2014, 43 people from Bolivia (or descendants) were enrolled. A total of 9.3% (4/43), of whom two women were of childbearing age, tested seropositive (ELISA and IFAT), and one also by PCR. For 2/4 positive participants, clinical evaluation was performed and the indeterminate form of CD was diagnosed. Knowledge about CD symptoms and ways of transmission were completely absent among 55.8% (24/43, 2/4 with CD) and 30.2% (13/43, 1/4 with CD) of participants, respectively. A total of 27.9% (12/43, 0/4 with CD) of participants had donated blood prior to the study, whereas 62.8% (27/43, 3/4 with CD) were motivated to donate blood in the future. The qualitative research identified lack of knowledge as well as stigma and fears related to CD.ConclusionsDespite the small number of participants, the prevalence of CD as well as the potential risk of non-vectorial transmission was alarming. Campaigns adapted for Latin American migrants as well as control strategies should be developed and put in place in order to prevent non-vectorial transmission and actively detect cases of CD in Germany.
Chinese patent medicine Fei-Liu-Ping ointment as an adjunctive treatment for non-small cell lung cancer: protocol for a systematic review
Authors: Zheng Honggang , He Shulin , Liu Rui , Xu Xinyao , Xu Tao , Chen Shuntai , Guo Qiujun , Gao Yebo , Hua Baojin 
Published: January 2017

IntroductionFei-Liu-Ping ointment has been widely applied as adjunctive drug in the treatment of non-small cell lung cancer (NSCLC). However, there has been no systematic review of research findings regarding the efficacy of this treatment. Here, we provide a protocol for assessing the effectiveness and safety of Fei-Liu-Ping ointment in the treatment of NSCLC.Methods and analysisThe electronic databases to be searched will include MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, Excerpt Medica Database (EMBASE), China National Knowledge Infrastructure (CNKI), China Scientific Journal Database (VIP), Wanfang Database and Chinese Biomedical Literature Database (CBM). Papers in English or Chinese published from inception to 2016 will be included without any restrictions. We will conduct a meta-analysis of randomised controlled trial if possible. The therapeutic effects according to the standard for treatment of solid tumours by the WHO and the quality of life as evaluated by Karnofsky score and weight will be applied as the primary outcomes. We will also evaluate the data synthesis and risk of bias using Review Manager 5.3 software.DisseminationThe results of this review will offer implications for the use of Fei-Liu-Ping ointment as an adjunctive treatment for NSCLC. This knowledge will inform recommendations by surgeons and researchers who are interested in the treatment of NSCLC. The results of this systematic review will be disseminated through presentation at a conference and publication of the data in a peer-reviewed journal.Trial registration numberPROSPERO CRD42016036911.
Dying at home of cancer: whose needs are being met? The experience of family carers and healthcare professionals (a multiperspective qualitative study)
Authors: Pottle Jackie , Hiscock Julia , Neal Richard D , Poolman Marlise 
Published: January 2017

ObjectivesSupporting patients to die in the place of their choosing is an important aspect of end of life care. Our study set out to answer the question: ‘How does the home environment influence perceptions of quality of death, and the experience of caring for the dying at home, for family carers and healthcare professionals (HCPs)?MethodsA qualitative approach, using multiperspective interviews with bereaved family carers (n=15) and a nominated HCP (n=13) ensured depth of insight gained into supporting a home death. The semistructured interviews were audio recorded, transcribed verbatim and analysed using Framework.ResultsWe found that the home environment enabled normality, a sense of control and individualised care which family carers often perceived as contributing towards a good death. However, the home environment created challenges for both family carers and HCPs, due to the differing and at times conflicting needs of the dying person and their family carers.ConclusionsWe have shed light on the complexity of balancing the demands and the satisfaction of caring for someone dying at home. The ability to manage these conflicting needs influenced whether carers perceived the home setting as the best place for the person to have received care in their last days of life.
Re-saturation targets identified from 4D seismic softening responses in the Forties Field
Authors: Singer Lyndsay , Byerley Grant , Rose Phil 
Published: January 2017

Abstract
A novel 4D methodology by targeting softening responses, a decrease in impedance over time, is described from the Forties Field. It is demonstrated that these anomalies identified areas where oil had re-saturated previously swept rock. When first observed in some of the older vintages of 4D data, softening responses were dismissed as side lobes of underlying water-swept reservoirs. With improved 4D data quality, softening responses were seen to be clearly responding to an acoustic softening effect isolated in the reservoir. Pressure measurements ruled out hypotheses of gas exsolution or geomechanically induced dilatation of the overlying shale.

At the time of writing 22 re-saturation targets had been drilled at Forties with an average water saturation (
S
w
) of 28%, close to virgin conditions. These results indicated that a previously swept sand can be re-saturated to near initial oil conditions.

The driving mechanism behind the re-saturation is understood to be related to changes in both production offtake and water injection. The resulting complex hydrodynamic interactions appeared to be moving banks of oil around the field. From 2011 to year-end of 2015 re-saturation targets produced 14.6 MMBO and were a key target type at the Forties Field.
An Efficient GPUAccelerated Implementation of Genomic Short Read Mapping with BWAMEM
Authors: Houtgast Ernst Joachim , Sima VladMihai , Bertels Koen , AlArs Zaid 
Published: January 2017

Next Generation Sequencing techniques have resulted in an exponential growth in the generation of genetics data, the amount of which will soon rival, if not overtake, other Big Data fields, such as astronomy and streaming video services. To become useful, this data requires processing by a complex pipeline of algorithms, taking multiple days even on large clusters. The mapping stage of such genomics pipelines, which maps the short reads onto a reference genome, takes up a significant portion of execution time. BWA-MEM is the de-facto industry-standard for the mapping stage.
Here, a GPU-accelerated implementation of BWA-MEM is proposed. The Seed Extension phase, one of the three main BWA-MEM algorithm phases that requires between 30%-50% of overall processing time, is offloaded onto the GPU. A thorough design space analysis is presented for an optimized mapping of this phase onto the GPU. The re- sulting systolic-array based implementation obtains a two- fold overall application-level speedup, which is the maximum theoretically achievable speedup. Moreover, this speedup is sustained for systems with up to twenty-two logical cores. Based on the findings, a number of suggestions are made to improve GPU architecture, resulting in potentially greatly increased performance for bioinformatics-class algorithms.
Migration of long-running Tasks between Reconfigurable Resources using Virtualization
Authors: Knodel Oliver , Genssler Paul R. , Spallek Rainer G. 
Published: January 2017

Computing performance and scalability are the essential basics in modern data centres. Field Programmable Gate Arrays (FPGAs) provide a promising opportunity to improve performance, security and energy efficiency. Especially background acceleration of computationally complex and long-running tasks is an important field of application. A flexible use of reconfigurable devices within a cloud context requires an abstraction of the actual hardware through virtualization.
In this paper we present an approach inspired by paravirtualized machines for the integration of reconfigurable hardware into cloud services. Using partial reconfiguration our hardware and software framework virtualizes a single physical FPGA to enable multiple independent user designs. Essential components are the management of those virtual user-defined accelerators (vFPGA) and their migration between physical FPGAs to achieve higher system-wide utilization. The migration requires saving and restoring the internal state or context of the vFPGA. We demonstrate the application possibilities and the resource trade-off of our approach by transferring a running design from one physical FPGA to another. Moreover, we present future perspectives for the use of FPGAs in cloud-based environments.
FPGA High-level Synthesis versus Overlay
Authors: Lin Colin Yu , Jiang Zhenghong , Fu Cheng , So Hayden Kwok-Hay , Yang Haigang 
Published: January 2017

To promote FPGA to a wider user community and to increase design productivity, two new design methodologies, namely FPGA high-level synthesis (HLS) and FPGA overlay, are presented to use a high-level design abstraction. To make clear distinguish features of each design methodology, we make an comparison of a state-of-the-art FPGA HLS tool, Vivado HLS, and an FPGA overlay tool, ArchSyn, on two computation intensive kernels, matrix-matrix multiplication and fast Fourier transform.
In the comparison, FPGA overlay shows an overwhelming superiority in computation performance, which is 8X to 39X faster than FPGA HLS. However, FPGA HLS exhibits its advantages in dynamic power consumption metric. It achieves up to 17X lower power consumption than FPGA overlay. Power- and energy-efficiency are another two essential metrics evaluating trade-offs between performance and power consumption. As demonstrated with evaluation results, FPGA overlay is averagely 3.5X better in powerefficiency for FFT kernel, and achieves up to 2 orders of magnitude better energy-efficiency than FPGA HLS.
The Superposition-Traffic Game
Authors: Hota Ashish R. , Honnappa Harsha , Sundaram Shreyas 
Published: January 2017

We consider a queuing game where a set of sources or players strategically send jobs to a single shared server. The traffic sources have disparate coefficients of variation of the interarrival times, and the sources are strategic in their choice of mean inter-arrival times (or the arrival rates). For every job completion, each player receives a benefit that potentially depends on the number of other players using the server (capturing network effects due to using the same server). However, the players experience a delay due to their jobs waiting in the queue. Assuming the service times have a general distribution with a finite second moment, we model the delay experienced by the superposed traffic using a Brownian approximation.
In our first contribution, we show that the total rate of job arrivals at a Nash equilibrium with n sources is larger when the sources have heterogeneous coefficients of variation, while the average delay experienced by a job is smaller, compared to the equilibrium with an equal number of homogeneous sources. In the second contribution, we characterize the equilibrium behavior of the queuing system when the number of homogeneous sources scales to infinity in terms of the rate of growth of the benefits due to network effects.
Beyond Bernoulli
Authors: Donati Fabrizio , Myerson Saul , Bissell Malenka M. , Smith Nicolas P. , Neubauer Stefan , Monaghan Mark J. , Nordsletten David A. , Lamata Pablo 
Published: January 2017

Background—
Transvalvular peak pressure drops are routinely assessed noninvasively by echocardiography using the Bernoulli principle. However, the Bernoulli principle relies on several approximations that may not be appropriate, including that the majority of the pressure drop is because of the spatial acceleration of the blood flow, and the ejection jet is a single streamline (single peak velocity value).

Methods and Results—
We assessed the accuracy of the Bernoulli principle to estimate the peak pressure drop at the aortic valve using 3-dimensional cardiovascular magnetic resonance flow data in 32 subjects. Reference pressure drops were computed from the flow field, accounting for the principles of physics (ie, the Navier–Stokes equations). Analysis of the pressure components confirmed that the spatial acceleration of the blood jet through the valve is most significant (accounting for 99% of the total drop in stenotic subjects). However, the Bernoulli formulation demonstrated a consistent overestimation of the transvalvular pressure (average of 54%, range 5%–136%) resulting from the use of a single peak velocity value, which neglects the velocity distribution across the aortic valve plane. This assumption was a source of uncontrolled variability.

Conclusions—
The application of the Bernoulli formulation results in a clinically significant overestimation of peak pressure drops because of approximation of blood flow as a single streamline. A corrected formulation that accounts for the cross-sectional profile of the blood flow is proposed and adapted to both cardiovascular magnetic resonance and echocardiographic data.
Structure Function Analysis of Water Vapor Simulated with a Convection-Permitting Model and Comparison to Airborne Lidar Observations
Authors: Selz Tobias , Fischer Lucas , Craig George C. 
Published: January 2017

Abstract
The spatial scale dependence of midlatitude water vapor variability in the high-resolution limited-area model COSMO is evaluated using diagnostics of scaling behavior. Past analysis of airborne lidar measurements showed that structure function scaling exponents depend on the corresponding airmass characteristics, and that a classification of the troposphere into convective and nonconvective layers led to significantly different power-law behaviors for each of these two regimes. In particular, scaling properties in the convective air mass were characterized by rough and highly intermittent data series, whereas the nonconvective regime was dominated by smoother structures with weaker small-scale variability. This study finds similar results in a model simulation with an even more pronounced distinction between the two air masses. Quantitative scaling diagnostics agree well with measurements in the nonconvective air mass, whereas in the convective air mass the simulation shows a much higher intermittency. Sensitivity analyses were performed using the model data to assess the impact of limitations of the observational dataset, which indicate that analyses of lidar data most likely underestimated the intermittency in convective air masses due to the small samples from single flight tracks, which led to a bias when data with poor fits were rejected. Though the quantitative estimation of intermittency remains uncertain for convective air masses, the ability of the model to capture the dominant weather regime dependence of water vapor scaling properties is encouraging.
Cold Pools and Their Influence on the Tropical Marine Boundary Layer
Authors: de Szoeke Simon P. , Skyllingstad Eric D. , Zuidema Paquita , Chandra Arunchandra S. 
Published: January 2017

Abstract
Cold pools dominate the surface temperature variability observed over the central Indian Ocean (0°, 80°E) for 2 months of research cruise observations in the Dynamics of the Madden–Julian Oscillation (DYNAMO) experiment in October–December 2011. Cold pool fronts are identified by a rapid drop of temperature. Air in cold pools is slightly drier than the boundary layer (BL). Consistent with previous studies, cold pools attain wet-bulb potential temperatures representative of saturated downdrafts originating from the lower midtroposphere.
Wind and surface fluxes increase, and rain is most likely within the ~20-min cold pool front. Greatest integrated water vapor and liquid follow the front. Temperature and velocity fluctuations shorter than 6 min achieve 90% of the surface latent and sensible heat flux in cold pools. The temperature of the cold pools recovers in about 20 min, chiefly by mixing at the top of the shallow cold wake layer, rather than by surface flux.
Analysis of conserved variables shows mean BL air is composed of 51% air entrained from the BL top (800 m), 22% saturated downdrafts, and 27% air at equilibrium with the ocean surface. The number of cold pools, and their contribution to the BL heat and moisture, nearly doubles in the convectively active phase compared to the suppressed phase of the Madden–Julian oscillation.
Amplification of the Downstream Wave Train during Extratropical Transition: Sensitivity Studies
Authors: Keller Julia H. 
Published: January 2017

Abstract
A tropical cyclone (TC) undergoing extratropical transition (ET) may support the amplification of a Rossby wave train in the downstream midlatitudes. Within the context of downstream baroclinic development, the TC acts as an additional source of eddy kinetic energy (). Previous studies concluded that the impact depends, in particular, on the phasing between the TC and the midlatitude flow and the continuation of the generation during ET. These studies did not quantify the impact of ET on the within a downstream Rossby wave train.
The present study uses ensemble sensitivity analysis to examine the sensitivity of downstream Rossby wave train amplification to the budget of the transitioning TC and of the upstream midlatitude features for Typhoon Choi-Wan (2009) and Hurricane Hanna (2008) in ECMWF ensemble forecasts. The amplification of the downstream wave train is measured using the amplitude of its associated maxima. The sensitivity of the maximum’s intensity at a particular forecast time to the budget terms of the TC and the upstream midlatitudes at earlier forecast times is determined. The results show that increasing the budget terms within Choi-Wan (Hanna) by one standard deviation can result in an up to 36% (23%) more intense downstream maximum. This is favored by the phasing between Choi-Wan and the midlatitude trough, and the reintensification of Hanna, respectively. By contrast, weaker contributions to downstream Rossby wave amplification arise from budget terms associated with flow features in the upstream midlatitudes.