bluuebunny/crossref_metadata_2025_split huggingface dataset:
10-Hydroxy Decanoic Acid and Zinc Oxide Nanoparticles Retrieve Nrf2/HO-1 and Caspase-3/Bax/Bcl-2 Signaling in Lead-Induced Testicular Toxicity
Authors: Maher Adham M. , Elsanosy Ghidaa A. , Ghareeb Doaa A. , Elblehi Samar S. , Saleh Samar R. 
Published: September 2024

AbstractThere has been a significant increase in human exposure to heavy metals (HMs) over the course of the previous century, primarily due to the extensive industrial processes. Male infertility is a prominent complication associated with lead exposure, wherein lead has the potential to accumulate within the testes, resulting in oxidative stress and inflammation. In addition, 10-hydroxydecanoic acid (10-HDA) is a component found in the secretions of worker bees and possesses the capacity to mitigate oxidative stress and prevent inflammation. Due to their advantageous properties, zinc oxide nanoparticles (ZnO-NPs) possess a wide range of applications in the field of biomedicine. This study aimed to assess the therapeutic effect of 10-HDA and ZnO-NPs on testicular toxicity in rats induced by lead acetate (PbAc). PbAc was administered orally for a period of 3 months. Following that, 10-HDA and/or ZnO-NPs were administrated for 1 month. PbAc deformed seminal analysis, decreased seminal fructose and sex hormonal levels, and resulted in the development of histopathological complications. Additionally, PbAc increased MDA and decreased Nrf2 and HO-1 expression, confirmed by the declined antioxidant defense system. Furthermore, an increase in testicular inflammatory markers and the Bax/Bcl-2 ratio was observed subsequent to the administration of PbAc. The administration of 10-HDA and ZnO-NPs demonstrated significant efficacy in the restoration of semen quality, pituitary/gonadal hormones, antioxidants, and testicular histoarchitecture. Moreover, 10-HDA and ZnO-NPs decreased testicular inflammatory markers and apoptotic proteins (caspase-3 and Bax expression levels). In conclusion, combining 10-HDA and ZnO-NPs demonstrated synergistic potential in treating PbAc-induced testicular toxicity, thereby presenting a promising approach in nanomedicine and natural drugs.
Bildgebung der Lentigo maligna
Authors: Pustelnik K. , Tschandl P. 
Published: September 2024

ZusammenfassungDie Lentigo maligna (LM) ist ein In-situ-Melanom chronisch aktinisch geschädigter Haut im Gesichtsbereich vorwiegend älterer Patient:innen. Spezielle Eigenschaften der Gesichtshaut, schwer abschätzbare subklinische Ausbreitung und Progression der LM sowie die Ähnlichkeit zu anderen UV-bedingten Läsionen führen zu diagnostischen und therapeutischen Herausforderungen für die LM. Zu den wichtigsten Werkzeugen der klinischen Evaluierung gehören die Dermatoskopie sowie ergänzend auch die In-vivo-Konfokalmikroskopie, während die Diagnosesicherung in der Regel durch die histopathologische Aufarbeitung in Zusammenschau mit immunhistochemischen Färbungen und klinischen Informationen erfolgt. Die Aufgabenstellungen für diese Werkzeuge umfassen neben der Primärdiagnostik auch die präoperative Planung von Resektionen, Beurteilung der Radikalität und Effektivität von Therapien sowie Evaluierung von potenziellen Rezidiven.
Exploring the limits of the provenience postulate: chemical and mineralogical characterization of Bronze Age ceramics from the Great Hungarian Plain
Authors: Golitko Mark , Riebe Danielle J. , Kreiter Attila , Duffy Paul R. , Parditka Györgyi 
Published: September 2024

AbstractDetermining the provenience of archaeological objects relies on the so-called “provenience postulate,” namely, that sources of these objects are more compositionally distinct from each other than they are internally variable. For ceramics, it can be relatively straightforward in geologically heterogeneous environments to determine where vessels were produced, and whether they were traded or not. In geologically homogeneous regions, this can be far more complicated. In this study, we mineralogically and chemically compare Bronze Age ceramics (primarily Middle Bronze Age) from five archaeological sites on the Great Hungarian Plain to a large regional clay sample. The Great Hungarian Plain is comprised almost entirely of Pleistocene loess deposits, yet prior compositional studies have identified patterned variability between ceramics from different sites. Our results show that chemical variation in the region is continuous and clinal, making it difficult to strictly apply the provenience postulate to identify distinct production locations. However, we show that this clinal chemical variability can be used to make broad statements about whether most ceramics at any given site were produced relatively locally or were obtained from further distances (c. 50 km or more). We show that while production at most of our study sites was likely relatively localized, in one instance (the tell at Berettyóújfalu-Herpály-Földvár), many ceramics may have been obtained from other Bronze Age communities, including those in the Körös River drainage.
Long-Term Effects of Transtheoretical Model-Based Lifestyle Intervention on Self-efficacy and Self-management in Patients with Type 2 Diabetes — Randomised Controlled Trial
Authors: Dunkel Annalena , von Storch Katja , Hochheim Martin , Zank Susanne , Polidori Maria Cristina , Woopen Christiane 
Published: September 2024

Abstract

Background
Self-efficacy and self-management are fundamental factors for successful treatment of type 2 diabetes, but long-term studies are rare. The aim of the present study is to investigate whether the effects achieved in the context of a lifestyle intervention based on the transtheoretical model can be maintained by the patients in the long term.

Method
A two-arm randomised controlled trial examined whether long-term effects of self-efficacy, self-management, and HbA1c can be achieved by a lifestyle intervention of 12 months and persisted beyond the intervention. During the intervention, the intervention group (n = 86, mean age 59.7 years) was supported by a telephone coach and telemedical devices, while the control group (n = 65, mean age 58.8 years) received regular care. In the year after intervention, both groups received standard care.

Results
The intervention group achieved significantly better self-management after 12 and 24 months (12M, 1.11 (0.81; 1.41) p < .000; 24M, 0.52 (0.19; 0.85) p = .002) as well as self-efficacy (12M, 1.18 (0.83; 1.52) p < .000; 24M, 0.76 (0.39; 1.13) p < .000) and HbA1c than the control group.

Conclusion
TTM-based lifestyle interventions show a long-term effect beyond the duration of the intervention in most areas, and behavioural changes can be sustained by patients.
Breinbrekers? Beter begrip van breinfunctie bij mensen bij spina bifida leidt tot betere zorg
Authors: Veenstra Wencke S. , Lammers Rianne J. M. 
Published: September 2024

SamenvattingPatiënten met spina bifida (SB), oftewel spinaal dysrafisme, hebben diverse hersenafwijkingen die hun dagelijks functioneren beïnvloeden. In dit artikel leggen we uit hoe die te onderzoeken zijn en wat de relevantie is voor de zorg voor adolescenten en (jong)volwassenen met SB. Voorspellers voor problemen met het functioneren zijn: het niveau van de laesie, de aanwezigheid van hydrocefalie, de aanwezigheid van ventriculaire-peritoneale draindisfunctie, de aanwezigheid van insulten en de sociaaleconomische status. In de praktijk kunt u merken dat mensen met SB verbaal sterk zijn, maar daarna toch in de problemen komen omdat executieve functies minder goed werken. Plannen, afspraken nakomen, therapietrouw en dergelijke kunnen lastig zijn voor patiënten met SB. Dit verergert naarmate de patiënt veroudert. Het helpt om informatie gedoseerd aan te bieden. Gebruik van korte zinnen en herhaling zijn belangrijk. Ook kan het revalidatieteam helpen, bijvoorbeeld door het inzetten van een neuropsychologisch onderzoek en/of het aanleren van compensatiestrategieën.
Vragen naar seksueel grensoverschrijdend gedrag binnen instellingen
Authors: Bicanic Iva A. E. , de Jong Dennis C. , de Kort Laetitia M. O. 
Published: September 2024

SamenvattingSeksueel misbruik komt veelvuldig voor, in het bijzonder bij mensen met een lichamelijke, zintuiglijke of verstandelijke beperking die in een instelling verblijven. In een wooninstelling zijn patiënten afhankelijk van zorgverleners, hetgeen een risicofactor vormt voor misbruik. Ook kan seksueel grensoverschrijdend gedrag bij bewoners onderling voorkomen. Er bestaat steeds meer evidentie voor het verband tussen urologische problemen en seksueel misbruik in de voorgeschiedenis. Inzicht in de relatie tussen seksueel misbruik, bekkenbodemoveractiviteit en urologische problemen biedt kansen voor traumaverwerking. Dit artikel beschrijft hoe urologen deze kennis in hun werkzaamheden kunnen toepassen bij patiënten die in een instelling verblijven, daarbij rekening houdend met de schaamte en schuld die aan deze ervaringen kleven. Ook worden concrete vragen en psycho-educatie voor in de spreekkamer beschreven.
Understanding Children’s Learning of Part–Whole Relations Using Fingu
Authors: Kortenkamp Ulrich , Ladel Silke , Larkin Kevin 
Published: September 2024

AbstractIn this article, we investigate the effects of the app Fingu on a child’s understanding of the part-whole concept. Using the Artifact Centric Activity Theory framework, we initially analyse the internalisation and externalisation processes that appear to occur during one child’s use of the app. Based on the learning from this process, we then use other aspects of the framework, in particular the subject-artifact-group triangle, to understand how Fingu might be used productively in mathematics education classrooms. Using a 13-min video of a child playing Fingu as our data source, we analyse how children might, as they learn about part-whole relationships, interact with the game. We also investigate how design principles in creating apps can impact on the experience of using the app in ways that may be unintended by their designers. This work has implications for app designers and for mathematics educators seeking to incorporate digital technologies into mathematics education.
Understanding community-based mental health interventions among migrant workers in Singapore
Authors: Kwek Theophilus 
Published: September 2024

Abstract
Background
Migrants in Singapore face unique mental health risk factors and barriers to formal care. Within this context, the Migrant Writers of Singapore (an arts collective) has organised a community-based intervention to address mental health needs, the Mental Health Awareness and Well-Being Festival.

Aim
To understand migrants’ motivations for organising and participating in the Festival as a form of community-based mental health support, as well as their perspectives on the role and effectiveness of such interventions.

Methods
Thematic analysis of semi-structured interviews conducted in October and November 2023, with 10 members of MWS involved in the Festival.

Results
Interviewees were primarily motivated by personal experiences of giving or receiving peer support, or finding relief through MWS’s arts-based activities; and to a smaller extent by the need for greater mental health awareness among migrants. Interviewees saw the value of community-based interventions in: (i) easing loneliness, (ii) establishing solidarity, (iii) facilitating communication in help-seeking, and (iv) building longer-term social networks.

Conclusions
Findings suggest that community-based interventions may be an enabler of peer support, and help address underlying mental health risk factors. Arts-based activities can enhance these interventions, though further research is required to evaluate concrete outcomes, and ascertain the wider applicability of these findings.
Modelling of morphogenesis to support the design of fungal-based engineered living materials
Authors: Carlström Vilhelm , Rigobello Adrien , Ayres Phil 
Published: September 2024

Abstract
To realize the potential of materials comprising living organisms, bioengineers require a holistic understanding of the reciprocal relationship between environmental conditions and the biochemical and biophysical processes that influence development and behaviour. Mathematical modelling has a critical part to play in managing the complexity of biological dynamical systems and attaining higher degrees of control over their trajectories and endpoints. To support the development of mycelium-based engineered living materials, this paper reviews the literature of growth models for filamentous fungi with emphasis on the connection between morphogenesis and metabolism.
On algebraic dependencies between Poincaré functions
Authors: PAKOVICH FEDOR 
Published: September 2024

AbstractLet A be a rational function of one complex variable of degree at least two, and
$z_0$
its repelling fixed point with the multiplier
$\unicode{x3bb} .$
A Poincaré function associated with
$z_0$
is a function meromorphic on
${\mathbb C}$
such that , and In this paper, we study the following problem: given Poincaré functions and , find out if there is an algebraic relation between them and, if such a relation exists, describe the corresponding algebraic curve
$f(x,y)=0.$
We provide a solution, which can be viewed as a refinement of the classical theorem of Ritt about commuting rational functions. We also reprove and extend previous results concerning algebraic dependencies between Böttcher functions.
A PARAMETERIZED HALTING PROBLEM, TRUTH AND THE MRDP THEOREM
Authors: CHEN YIJIA , MÜLLER MORITZ , YOKOYAMA KEITA 
Published: September 2024

Abstract
We study the parameterized complexity of the problem to decide whether a given natural number n satisfies a given

$\Delta _0$

-formula

$\varphi (x)$

; the parameter is the size of

$\varphi $

. This parameterization focusses attention on instances where n is large compared to the size of

$\varphi $

. We show unconditionally that this problem does not belong to the parameterized analogue of

$\mathsf {AC}^0$

. From this we derive that certain natural upper bounds on the complexity of our parameterized problem imply certain separations of classical complexity classes. This connection is obtained via an analysis of a parameterized halting problem. Some of these upper bounds follow assuming that

$I\Delta _0$

proves the MRDP theorem in a certain weak sense.
Why business adoption of quantum and AI technology must be ethical
Authors: Hoffmann Christian Hugo , Flöther Frederik F. 
Published: September 2024

Abstract
Artificial intelligence (AI) recently had its “iPhone moment” and adoption has drastically accelerated. Quantum computing appears poised to follow suit over the next years. However, while there has been discourse about how to use AI responsibly, there is still little appreciation and awareness among executives, managers and practitioners about the broader ethical questions and implications raised by the intersection of these emerging technologies. In this article, it is highlighted why quantum computing and AI ethics must be taken seriously by businesspersons and how these technologies affect strategic decisions; moreover, recommendations and action areas are formulated.
The Textual Demiurge: Social Status and the Academic Discourse of Early Christian Forgery
Authors: Coogan Jeremiah , Moss Candida R. 
Published: September 2024

AbstractThis article reconsiders the classed and gendered construction of the Author in the Roman Mediterranean, a construction that generates the intertwined notions of authorship and authenticity. Modern scholarly conversations about authorship and pseudepigraphy in the Roman Mediterranean often proceed from the uninterrogated assumptions that (a) ancient texts (including early Christian texts) were the monographic products of solitary authors and (b) everyone in antiquity, regardless of gender or class, had access to the status of being an ‘Author’. While conversations about (in)authentic textual production extend beyond the works that become part of the New Testament, these twin assumptions form the basis for modern debates about ‘forgery’ in New Testament literature. This article challenges both assumptions by first surveying the role of uncredited collaboration in Roman literary culture and then analysing ancient Christian discourses surrounding (a) illicit textual meddling and (b) inappropriate textual ascription. These two discursive categories reveal how the categories of class and gender are entangled with early Christian ideas of the Author. Ancient discourses of authenticity and authorship were not simply about who produced texts but about policing which acts of textual production count as ‘authoring’.
This Hand is Validation: Philemon as a Pauline Holograph
Authors: Elder Nicholas A. 
Published: September 2024

AbstractOn five occasions in Pauline literature, the author claims to write in their own hand. In three of the five instances, the autograph is reserved for the final greeting and the greeting alone. In Galatians 6.11 and Philemon 19, however, Paul writes more than the letter's greeting in his own hand, as the comment about his autograph appears well before the closing salutations. This article engages one of these texts, Philemon, and argues that it was written entirely in Paul's hand. The letter was a Pauline holograph. To make this argument, the article first assesses the ‘cheirographic rhetoric’ of Philemon 19. Paul alludes to a type of documentary writing, the cheirograph, that recorded various sorts of financial proceedings. Paul's autographic guarantee recalls validation statements that were integral to this genre of text. Comparanda from the non-literary papyri show that when an author of a cheirograph called specific attention to their own handwriting, the entire document was customarily written in their own hand. The article then turns to the personal nature of Philemon and the abundance of second-person singular forms, arguing that there was a strong preference that personal letters like Philemon be handwritten in Paul's context. Taken together, these two arguments demonstrate that Paul's short letter to Philemon was more likely to be handwritten than dictated.
Turnip hoeing matches in Aberdeenshire, 1840–1940: Material practice and cultural impact
Authors: Mutch Alistair 
Published: September 2024

AbstractThis article explores the competitive hoeing matches, which were a significant feature of certain parts of Scottish rural life in the period 1840 to 1940. An analysis of newspaper reports shows how important such matches were in Aberdeenshire, attracting significant numbers of both competitors and spectators. By contrast, similar reports for the rest of Scotland show only a small number of such matches outside the northeast. Reasons for the differences are attributed to both material factors, such as the visibility of cultivation, and the social structure of the areas. In Aberdeenshire, a culture valorising hard work and skill was set in a social structure of small farmers and farm servants, which led to self-sustaining organisational forms. By contrast, elsewhere a top-down form of organisation prioritising the needs of farm productivity meant that competitive hoeing matches failed to kindle much enthusiasm. The value of a focus on taken-for-granted practices is the way it can shed light on such contrasts.
‘Living in the Present’ mindfulness for parents of children with skin conditions: a single group case series
Authors: Hughes Olivia , Shelton Katherine H. , Penny Helen , Thompson Andrew R. 
Published: September 2024

AbstractBackground:Parents of children with skin conditions can experience stress from the additional responsibilities of care. However, there is a lack of psychological interventions for families affected by a dermatological diagnosis.Aims:To investigate (1) whether delivering the ‘Living in the Present’ mindfulness curriculum to parents of children with skin conditions reduced stress and increased both parental/child quality of life (QoL), and (2) determine intervention acceptability.Method:Ten parents of children with eczema, ectodermal dysplasia, ichthyosis, and alopecia took part in a mindfulness-based intervention. Using mixed methods, a single-group experimental case design (SCED) was conducted and supplemented by thematic analysis of exit interviews. Parents completed idiographic measures of parenting stress, standardised measures of QoL, stress, mindfulness, and took part in exit interviews. Children also completed QoL measures.Results:Tau-U analysis of idiographic measures revealed three parents showed some significant improvements in positive targets, and five parents showed some significant improvements in negative targets. Assessment of reliable change demonstrated that: one parent showed improvement in mindful parenting, three parents showed improvement in parenting stress, seven parents showed improvement in anxiety, three parents showed improvements in depression, six parents showed improvement in QoL, and four children showed improvement in QoL. However, two parents showed increased anxiety. Thematic analysis revealed positive changes to mood following mindfulness, although challenges were highlighted, including sustaining home practice.Conclusion:Findings suggest this specific form of mindfulness intervention could be effective for parents of children with skin conditions; however, further robust studies are needed.
Development and psychometric properties of the Health Anxiety Behavior Inventory (HABI)
Authors: Hedman-Lagerlöf Erik , Björkander Daniel , Andersson Erik , Axelsson Erland 
Published: September 2024

AbstractBackground:Mainstream cognitive behavioural theory stipulates that clinically significant health anxiety persists over time at least partially due to negatively reinforced health-related behaviours, but there exists no broad and psychometrically valid measure of such behaviours.Aims:To draft and evaluate a new self-report scale – the Health Anxiety Behavior Inventory (HABI) – for the measurement of negatively reinforced health anxiety behaviours.Method:We drafted the HABI from a pool of 20 candidate items administered in a clinical trial at screening, and before and after cognitive behaviour therapy (n=204). A psychometric evaluation focused on factor structure, internal consistency, convergent and discriminant validity, test–retest reliability, and sensitivity to change.Results:Based on factor analysis, the HABI was completed as a 12-item instrument with a four-dimensional factor structure corresponding to the following scales: (i) bodily preoccupation and checking, (ii) information- and reassurance-seeking, (iii) prevention and planning, and (iv) overt avoidance. Factor inter-correlations were modest. The internal consistency (α=.73–.87) and 2-week test–retest reliability (r=.75–.90) of the scales was adequate. The bodily preoccupation and checking, and information- and reassurance-seeking scales were most strongly correlated with the cognitive and emotional components of health anxiety (r=0.41, 0.48), and to a lower extent correlated to depressive symptoms and disability. Change scores in all HABI scales correlated with improvement in the cognitive and emotional components of health anxiety during cognitive behaviour therapy.Conclusions:The HABI appears to reliably measure negatively reinforced behaviours commonly seen in clinically significant health anxiety, and might be clinically useful in the treatment of health anxiety.