bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fuzzy ripple artifact in high resolution fMRI: identification, cause, and mitigation
Authors: Huber Renzo , Stirnberg Rüdiger , Morgan A Tyler , Feinberg David A , Ehses Philipp , Knudsen Lasse , Gulban Omer Faruk , Koiso Kenshu , Swegle Stephanie , Gephart Isabel , Wardle Susan G , Persichetti Andrew , Beckett Alexander JS , Stöcker Tony , Boulant Nicolas , Poser Benedikt A , Bandettini Peter 
Published: September 2024

AbstractPurposeHigh resolution fMRI is a rapidly growing research field focused on capturing functional signal changes across cortical layers. However, the data acquisition is limited by low spatial frequency EPI artifacts; termed here as Fuzzy Ripples. These artifacts limit the practical applicability of acquisition protocols with higher spatial resolution, faster acquisition speed, and they challenge imaging in lower brain areas.MethodsWe characterize Fuzzy Ripple artifacts across commonly used sequences and distinguish them from conventional EPI Nyquist ghosts, off-resonance effects, and GRAPPA artifacts. To investigate their origin, we employ dual polarity readouts.ResultsOur findings indicate that Fuzzy Ripples are primarily caused by readout-specific imperfections in k-space trajectories, which can be exacerbated by inductive coupling between third-order shims and readout gradients. We also find that these artifacts can be mitigated through complex-valued averaging of dual polarity EPI or by disconnecting the third-order shim coils.ConclusionThe proposed mitigation strategies allow overcoming current limitations in layer-fMRI protocols:Achieving resolutions beyond 0.8mm is feasible, and even at 3T, we achieved 0.53mm voxel functional connectivity mapping.Sub-millimeter sampling acceleration can be increased to allow sub-second TRs and laminar whole brain protocols with up to GRAPPA 8.Sub-millimeter fMRI is achievable in lower brain areas, including the cerebellum.
Evolution of the skull in arvicoline cricetids (Rodentia) according to 3D morphometric insights: Part 1. Morphological disparity of the palato-spheno-pterygoid complex
Authors: Voyta Leonid L. , Melnikov Daniel A. 
Published: September 2024

ABSTRACTOur paper is the first contribution to the comprehensive analysis of the complicated evolution of cranial and mandibular parts connected by pterygoid muscles, as part of more global investigation into adaptive evolution of Arvicolinae. The analysis was performed on 90 micro-computed-tomography–scanned specimens from 33 species from 19 genera of Arvicolinae as well as two species from two genera of Cricetinae as an outgroup. We revised 11 morphological traits of the “palato-spheno-pterygoid” complex, including key features of the palatine that are highly important for defining Arvicolinae taxa according to the micro-computed-tomography data. We also homologized characters of the posterior palatal margin and categorized the composition of the palatal elements into two main morphotypes: morphotype “A” is unique to Clethrionomyini and morphotype “B” was subdivided into three additional types and was found to occur in the outgroup (cricetines), voles (B2), and lemmings (B3). Morphospace analysis of the palato-spheno-pterygoid complex by means of the three-dimensional dataset revealed a mode of transformation of morphotype “A” into morphotype “B2.” A separate task was the development of a protocol for the preparation of morphological data for subsequent evaluation of genotype–phenotype relationships using specialized software applications (e.g., RERconverge).
The golden Syrian hamster (Mesocricetus auratus) as a model to decipher relevant pathogenic aspects of sheep-associated malignant catarrhal fever
Authors: Fabian Rosalie , Bentley Eleanor G , Kirby Adam , Sharma Parul , Stewart James P. , Kipar Anja 
Published: September 2024

AbstractMalignant catarrhal fever (MCF) is an often fatal sporadic gammaherpesvirus-induced disease of ruminants with global relevance. Ovine gammaherpesvirus-2 (OvHV-2), with sheep as reservoir host, is a major cause of MCF in susceptible species. Despite extensive research on the molecular aspects of the disease, its pathogenesis is not yet fully understood. The present study re-established the Syrian golden hamster (Mesocricetus auratus) as amenable animal model of MCF and applied complementaryin situapproaches to confirm recent findings in natural disease that could shed new light on pathogenetic aspects of MCF. These showed that systemic OvHV-2 infection is associated with T cell and macrophage dominated mononuclear infiltrates and vasculitis in various organs. Both T cells and monocytes/macrophages harbor the virus, and infected leukocytes are abundant in the infiltrates. The results also indicate that OvHV-2 has a broader target cell spectrum, including vascular endothelial cells and selected squamous epithelia. The former supports the interpretation that the inflammatory processes develop due to circulating activated, infected T cells and monocytes that home to tissues and emigrate from vessels prone to leukocyte emigration, possibly with direct interaction between virus infected leukocytes and endothelial cells. The latter supports the hypothesis of a graft versus host disease scenario, without viral cytopathic effect on epithelial cells but infiltration of the mucosa by infected T cells and macrophages. The disease processes are accompanied by evidence of expansion of the T cell compartments and the monocyte/macrophage pool in lymphatic tissues and bone marrow.
Population Genomics ofPlasmodium malariaefrom Four African Countries
Authors: Popkin-Hall Zachary R. , Carey-Ewend Kelly , Aghakhanian Farhang , Oriero Eniyou C. , Seth Misago D. , Kashamuka Melchior M. , Ngasala Billy , Ali Innocent M. , Mukomena Eric Sompwe , Mandara Celine I. , Kharabora Oksana , Sendor Rachel , Simkin Alfred , Amambua-Ngwa Alfred , Tshefu Antoinette , Fola Abebe A. , Ishengoma Deus S. , Bailey Jeffrey A. , Parr Jonathan B. , Lin Jessica T. , Juliano Jonathan J. 
Published: September 2024

AbstractPlasmodium malariaeis geographically widespread but neglected and may become more prevalent asP. falciparumdeclines. We completed the largest genomic study of AfricanP. malariaeto-date by performing hybrid capture and sequencing of 77 isolates from Cameroon (n=7), the Democratic Republic of the Congo (n=16), Nigeria (n=4), and Tanzania (n=50) collected between 2015 and 2021. There is no evidence of geographic population structure. Nucleotide diversity was significantly lower than in co-localizedP. falciparumisolates, while linkage disequilibrium was significantly higher. Genome-wide selection scans identified no erythrocyte invasion ligands or antimalarial resistance orthologs as top hits; however, targeted analyses of these loci revealed evidence of selective sweeps around four erythrocyte invasion ligands and six antimalarial resistance orthologs. Demographic inference modeling suggests that AfricanP. malariaeis recovering from a bottleneck. Altogether, these results suggest thatP. malariaeis genomically atypical among humanPlasmodiumspp. and panmictic in Africa.
Epidemiological profile of patients diagnosed with covid-19 in the municipality of São Gonçalo, Rio de Janeiro, Brazil
Authors: das Chagas Raphael Rangel , Freitas Hércules Rezende , Cardozo Sergian Vianna 
Published: September 2024

AbstractObjectivesThe global health crisis caused by SARS-CoV-2 has led to over 760 million confirmed cases and 6.8 million deaths worldwide, primarily impacting the respiratory system with symptoms varying from mild to severe. This study aimed to analyze the interplay between vaccination status, sociodemographic profiles, comorbidities, and COVID-19 outcomes.Study DesignObservational, cross-sectional, and analytical.MethodsThe study analyzed data from 6,953 individuals, examining vaccination statuses, sociodemographic profiles, comorbidities, COVID-19 test results, and other relevant variables. The cohort comprised predominantly mixed-race (51%), Caucasian (38%), and Black (9.5%) individuals, with 61% being female and 60% aged between 21-50 years. Prevalent comorbidities included hypertension (18.2%), diabetes (4.9%), and obesity (0.4%).ResultsPopulation-weighted analysis revealed significant associations between sociodemographic factors and COVID-19 test outcomes. Younger age groups, particularly 11-30 years, had higher positivity rates, which declined with age. Caucasians exhibited higher positivity rates (40.1%) compared to other ethnicities. Cramér’s V indicated small correlations between symptoms and test outcomes, notably with loss of taste (V = 0.11) and smell (V = 0.08). Odds ratio analysis identified hypertension as significantly associated with higher COVID-19 positivity (OR = 1.54, 95% CI: 1.28-1.83, p < 0.001), while obesity was associated with lower positivity (OR = 0.13, 95% CI: 0.02-0.63, p = 0.025). Symptoms such as fever, cough, loss of taste, loss of smell, and myalgia also showed significant associations with positive test outcomes.ConclusionsThis study provides valuable insights into the complex interplay of sociodemographic characteristics, comorbidities, symptoms, and COVID-19 outcomes.
COVID-19 real world data infrastructure: A big data resource for study of the impact of COVID-19 in patient populations with immunocompromising conditions
Authors: Crawford James M. , Penberthy Lynne , Pinto Ligia A. , Althoff Keri N. , Assimon Magdalene M. , Cohen Oren , Gillim Laura , Hammonds Tracy L. , Kapur Shilpa , Kaufman Harvey W. , Kwasny David , Liew Jean W. , Meyer William A. , Reynolds Shannon L. , Schleicher Cheryl B. , Subbiah Suki , Theruviparampil Catherine , Wallace Zachary S. , Warner Jeremy L. , Yoon Suhyeon , Ziemba Yonah C. 
Published: September 2024

AbstractBackgroundWe created a United States-based real-world data resource to better understand the continued impact of the COVID-19 pandemic on immunocompromised patients, who are typically under-represented in prospective studies and clinical trials.Methods:The COVID-19 Real World Data infrastructure (CRWDi) was created by linking and harmonizing deidentified HealthVerity medical and pharmacy claims data from December 1, 2018 to December 31, 2023, with SARS-CoV-2 virologic and serologic laboratory data from major commercial laboratories and Northwell Health; COVID-19 vaccination data; and for patients with cancer, 2010 to 2021 National Cancer Institute Surveillance, Epidemiology, and End Results registry data.Results:The CRWDi dataset contains data on 5.2 million people. Four populations were included in the dataset: (1) patients with cancer (n=1,294,022); (2) patients with rheumatic conditions receiving pharmacotherapy (n=1,636,940); (3) non-cancer solid organ (n=249,797) and hematopoietic stem cell (n=30,172) transplant recipients; and (4) people from the general population including adults (>18 years of age; n=1,790,162) and pediatric patients (<18 years of age; n=198,907).ConclusionsWe have created a complex real-world data system to address unanswered questions that have arisen during the COVID-19 pandemic. Further, by making the data broadly and freely available to academic researchers from the United States, the CRWDi real-world data system represents an important complement to existing consortia studies and clinical trials that have emerged during the healthcare crisis, and is readily reproducible for future purposing.SummaryThe COVID-19 Real World Data infrastructure dataset contains 5.2 million deidentified patient records, with focus on immunocompromising conditions, and is freely available to approved researchers to study the impact of coronavirus disease 2019 (COVID-19) on patient morbidities and outcomes.
Primary aldosteronism results in a decline estimated glomerular filtration rate independent of blood pressure: evidence from a case-control and mendelian randomization study
Authors: xu mingjie , Yan Boteng , Li Mingli , Wei Yushuang , Jin Xihui , Mai Xiaoyou , Liang Hui , Lan Haiyun , Xie Wenchao , Pang Tianjiao , Lin Qiang , Chen Yifeng , Zhou Zeguang , Wu Yongxian , Long Xinyang , Huang Shengzhu , Tang Chaoyan , Mo Zengnan 
Published: September 2024

ABSTRACT Background: Primary aldosteronism (PA) is the predominant cause of secondary hypertension, leading to cardiovascular and renal damage via mechanisms such as oxidative stress and fibrosis. However, current epidemiology findings on the association between PA and estimated glomerular filtration rate (eGFR) remain inconsistent. Methods: A 1:1 sex- and age-matched case-control study was conducted among participants with PA, essential hypertension (EH), and normotension, with 204 participants in each group. Multiple linear regression was used to explore the correlations of PA, plasma aldosterone concentration (PAC), plasma renin concentration (PRC), and the aldosterone-to-renin ratio (ARR) with eGFR. Additionally, we performed a bidirectional two-sample mendelian randomization (MR) analysis to assess the causal relationship between PA and eGFR based on public genome wide association study (GWAS) databases, and established a multivariable MR (MVMR) analysis to further explore whether the causal effect of PA on eGFR decline independent of systolic (SBP) or diastolic blood pressure (DBP). Results: Multiple linear regression model showed that PA was associated with a decline eGFR (β = -0.234, [95% CI, -0.099, -0.039], P<0.001) after adjusted potential confounders. When stratified the PA patients into three groups according to the levels of PAC, PRC and ARR, patients in the highest PAC groups (β = -0.146 [95% CI, -0.093, -0.008], P =0.021), the lowest PRC group (β = -0.127 [95% CI, -0.084, -0.004], P =0.033), and the highest ARR group (β = -0.147 [95% CI, -0.092, -0.009], P =0.017) had much lower eGFR compared to the EH group. The inverse associations mentioned above remained significant even further adjusted for SBP or DBP, respectively. Besides, MR results indicated that genetically predicted PA was causally associated with a decline eGFR (β =-6.671×10-4[95% CI,-1.291×10-4,-4.328×10-5], P = 0.036), consistent effects were further detected in SBP (β =-1.121×10-3 [95% CI,-2.132×10-3,-1.110×10-4], P = 0.029) or DBP (β =-1.542×10-3,[95% CI,-2.693×10-3,-3.912×10-4], P = 0.008) adjusted model using MVMR analysis. Conclusion: Our study indicates that PA is causally associated with lower eGFR independent of blood pressure, and the adverse effects might be greater than negative controls or EH patients.
Restoring transient connectivity during development improves dysfunctions in fragile X mice
Authors: Dumontier Dimitri , Liebman Samuel A. , Le Viet-Hang , George Shanu , Valdemar Deasia , Van Aelst Linda , Pouchelon Gabrielle 
Published: September 2024

AbstractEarly-generated circuits are critical for the maturation of cortical network activity and the formation of excitation/inhibition (E/I) balance. This process involves the maturation of specific populations of inhibitory neurons. While parvalbumin (PV)-expressing neurons have been associated with E/I impairments observed in neurodevelopmental disorders, somatostatin-expressing (SST) neurons have recently been shown to regulate PV neuron maturation by controlling neural dynamics in the developing cortex. SST neurons receive transient connections from the sensory thalamus, yet the implications of transient connectivity in neurodevelopmental disorders remain unknown. Here, we show that thalamocortical connectivity to SST neurons is persistent rather than transient in a mouse model of Fragile X syndrome. We were able to restore the transient dynamics using chemogenetics, which led to the recovery of fragile X-associated dysfunctions in circuit maturation and sensory-dependent behavior. Overall, our findings unveil the role of early transient dynamics in controlling downstream maturation of sensory functions.
Exploration of the polarization angle variability of the Crab Nebula with POLARBEAR and its application to the search for axionlike particles
Authors: Adachi Shunsuke , Adkins Tylor , Baccigalupi Carlo , Chinone Yuji , Crowley Kevin T. , Errard Josquin , Fabbian Giulio , Feng Chang , Fujino Takuro , Hasegawa Masaya , Hazumi Masashi , Jeong Oliver , Kaneko Daisuke , Keating Brian , Kusaka Akito , Lee Adrian T. , Lonappan Anto I. , Minami Yuto , Murata Masaaki , Piccirillo Lucio , Reichardt Christian L. , Siritanasak Praween , Spisak Jacob , Takakura Satoru , Teply Grant P. , Yamada Kyohei ,   POLARBEAR Collaboration
Published: September 2024

The Crab Nebula, also known as Tau A, is a polarized astronomical source at millimeter wavelengths. It has been used as a stable light source for polarization angle calibration in millimeter-wave astronomy. However, it is known that its intensity and polarization vary as a function of time at a variety of wavelengths. Thus, it is of interest to verify the stability of the millimeter-wave polarization. If detected, polarization variability may be used to better understand the dynamics of Tau A, and for understanding the validity of Tau A as a calibrator. One intriguing application of such observation is to use it for the search of axionlike particles (ALPs). Ultralight ALPs couple to photons through a Chern-Simons term, and induce a temporal oscillation in the polarization angle of linearly polarized sources. After assessing a number of systematic errors and testing for internal consistency, we evaluate the variability of the polarization angle of the Crab Nebula using 2015 and 2016 observations with the 150 GHz P instrument. We place a median 95% upper bound of polarization oscillation amplitude A<0.065° over the oscillation frequencies from 0.75  year−1 to 0.66  hour−1. Assuming that no sources other than ALP are causing Tau A’s polarization angle variation, that the ALP constitutes all the dark matter, and that the ALP field is a stochastic Gaussian field, this bound translates into a median 95% upper bound of ALP-photon coupling gaγγ<2.16×10−12  GeV−1×(ma/10−21  eV) in the mass range from 9.9×10−23  eV to 7.7×10−19  eV. This demonstrates that this type of analysis using bright polarized sources is as competitive as those using the polarization of cosmic microwave background in constraining ALPs.

Published by the American Physical Society
2024
Market power and wages: evidence from Brazil
Authors: Cavalcanti Gonçalves Ferreira Pedro 
Published: September 2024

PurposeThe paper examines the impact of market power on wages within the context of a developing country, focusing on Brazil.Design/methodology/approachWith access to matched employer–employee data from Brazil, we first characterized the evolution of the local labor market concentration (Municipality Herfindahl–Hirschman Index [HHI]). Then, we built a fixed-effect model with instrumental variables to verify the association between the local labor market concentration and wages. Finally, a difference-in-difference (DiD) was implemented to verify whether a merger transaction impacted the workers’ earnings in the Brazilian banking sector.FindingsThe paper’s findings suggest that there may be a negative relationship between market power and workers’ earnings.Originality/valueThis research conducted an in-depth investigation of the labor market power in a developing country. As far as we know, our work is the first to evaluate the extension of local concentration in Brazilian formal labor markets and to illustrate its evolution over the last decades. Additionally, when going through the effects of market concentration on wages, we use a new identification strategy that explores changes in the HHI that are caused by national trends in an industry as a source of exogenous variation. Finally, the last part of the paper assesses the effects of antitrust policy on the labor market, a kind of investigation that is still scarce.
“Every idea made life easier:” A critical discourse analysis of creative employee-driven innovation in the Italian healthcare system
Authors: Manfrini Caterina , Bäckström Izabelle 
Published: September 2024

PurposeThe purpose of this study is to scrutinize the connection between creativity and innovation in the context of public healthcare. This is achieved by applying the theoretical concept of employee-driven innovation (EDI) to explore employees’ perceptions of their creative engagement in innovation processes, as well as to capture the managerial implications of setting up such processes in the sector.Design/methodology/approachA critical discourse analysis (CDA) is applied as a methodological lens to capture the interaction between the macro-level production and meso-level distribution of innovation discourse (top-down), and the micro-level perception of, and response to, the same (bottom-up). This study is based on a qualitative approach and is set in the public healthcare system of the Autonomous Province of Trento, Northeast Italy. In total, 26 semi-structured interviews were conducted with 22 healthcare professionals. For triangulation purposes, observation and document analysis were also performed.FindingsThe findings of this study reveal that tensions are present between the macro-level discourses and the meso-level strategies around innovation, and the micro-level perceptions of employees’ creative engagement in innovation processes. Healthcare professionals’ creative efforts are not easily recognized and supported by top management, which in turn does not receive a framework of reference in policies acknowledging the importance of human skills and creativity in innovation processes.Research limitations/implicationsThat this is a single case study implies a limitation on the generalizability of its results, but the results may nevertheless be transferable to similar empirical contexts. Therefore, a multiple case study design would be preferable in future studies in order to study EDI strategies and policies across various types of organizations in the public sector. Moreover, apart from CDA, other theoretical and methodological lenses can be applied to investigate the interaction between top-down organizing and bottom-up responses to innovation.Originality/valueThis study contributes to the EDI literature by providing a more integrative understanding of EDI in the public sector, demonstrating the importance of scrutinizing the interactions between employees and top-level management.
Online customer-to-customer (C2C) incivility: impacts of managerial responses in digital customer service settings
Authors: Wei Wei 
Published: September 2024

PurposeThis research addressed online customer-to-customer (C2C) incivility during digital service recovery.Design/methodology/approachTo examine the effectiveness of managerial responses to online C2C incivility post a restaurant service failure, a 2 (Managerial response: general vs specific) x 2 (Failure severity: high vs low) quasi-experimental design was employed. A pretest was conducted with 123 restaurant consumers via Amazon Mechanical Turk, followed by a main study with 174 restaurant consumers. Taking a mixed-method approach, this research first asked open-ended questions to explore how participants perceived the restaurant’s motivation for providing a generic versus a specific response. Hayes’ (2013) PROCESS procedure was then performed for hypotheses testing.FindingsThe results revealed significant interaction effects of managerial responses and failure severity on perceived online service climate and revisit intention, mediated by trust with managerial responses.Originality/valueThis research yielded unique insight into C2C incivility management literature and industry practices in the context of digital customer service recovery.