bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development of polymers and fibers: an interview with Stephen Cheng
Authors: Yan Wei 
Published: October 2024

ABSTRACT
Polymer and fiber science has evolved significantly since the 1920s, with polymers becoming integral to both industry and daily life. China's fiber research, initiated in the 1950s, has made substantial societal and technological contributions, particularly in chemical fibers. How will future advancements in polymers and fibers address ongoing challenges and drive further innovation?
NSR spoke to Prof. Stephen Cheng, a member of the National Academy of Engineering (U.S.) and former Dean of the College of Polymer Science and Polymer Engineering at the University of Akron. He is currently Dean and Honorable Professor at South China University of Technology. His research interests center on the condensed states in polymers, liquid crystals, surfactants and hybrid materials, focusing on the interactions, responses, dynamics and structures of materials at varying lengths, energy and timescales, in which the material itself embodies the technology.
Altered Spike Immunoglobulin G Fc N-Linked Glycans Are Associated With Hyperinflammatory State in Adult Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children
Authors: Sherman Jacob D , Karmali Vinit , Kumar Bhoj , Simon Trevor W , Bechnak Sarah , Panjwani Anusha , Ciric Caroline R , Wang Dongli , Huerta Christopher , Johnson Brandi , Anderson Evan J , Rouphael Nadine , Collins Matthew H , Rostad Christina A , Azadi Parastoo , Scherer Erin M 
Published: October 2024

Abstract

Background
Severe coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome (MIS-C) are characterized by excessive inflammatory cytokines/chemokines. In adults, disease severity is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific immunoglobulin G (IgG) Fc afucosylation, which induces proinflammatory cytokine secretion from innate immune cells. This study aimed to define spike IgG Fc glycosylation following SARS-CoV-2 infection in adults and children and following SARS-CoV-2 vaccination in adults and the relationships between glycan modifications and cytokines/chemokines.

Methods
We analyzed longitudinal (n = 146) and cross-sectional (n = 49) serum/plasma samples from adult and pediatric COVID-19 patients, MIS-C patients, adult vaccinees, and adult and pediatric controls. We developed methods for characterizing bulk and spike IgG Fc glycosylation by capillary electrophoresis and measured levels of 10 inflammatory cytokines/chemokines by multiplexed enzyme-linked immunosorbent assay.

Results
Spike IgG was more afucosylated than bulk IgG during acute adult COVID-19 and MIS-C. We observed an opposite trend following vaccination, but it was not significant. Spike IgG was more galactosylated and sialylated and less bisected than bulk IgG during adult COVID-19, with similar trends observed during pediatric COVID-19/MIS-C and following SARS-CoV-2 vaccination. Spike IgG glycosylation changed with time following adult COVID-19 or vaccination. Afucosylated spike IgG exhibited inverse and positive correlations with inflammatory markers in MIS-C and following vaccination, respectively; galactosylated and sialylated spike IgG inversely correlated with proinflammatory cytokines in adult COVID-19 and MIS-C; and bisected spike IgG positively correlated with inflammatory cytokines/chemokines in multiple groups.

Conclusions
We identified previously undescribed relationships between spike IgG glycan modifications and inflammatory cytokines/chemokines that expand our understanding of IgG glycosylation changes that may impact COVID-19 and MIS-C immunopathology.
Beyond tracking: Advancing animal ecology through the longitudinal sampling of individuals
Authors: Dossman Bryant C , Filiberti Emily , Roth Amber M , Marra Peter P 
Published: October 2024

ABSTRACT
Rarely, is there an opportunity to study and directly observe the same migratory animal across both breeding and nonbreeding seasons. In a rare, documented case, we highlight a live reencounter of a female Setophaga ruticilla (American Redstart) on its nest during the breeding season—an individual that was originally captured and tagged on its nonbreeding territory in Jamaica more than 3,250 km away. Advances in tracking technology allow researchers to track the movements of smaller organisms at higher resolutions. While tracking data alone have provided critical advances in the ecology of migratory animals, especially small migratory birds, there are exciting opportunities to move beyond tracking and to deeply explore biological questions about migratory animals by locating and directly studying (e.g., direct observation and physical sampling) the same individuals across the year. Although we have had the ability to precisely track large-bodied migratory birds (&gt;100 g) for decades, researchers have rarely used these data to localize and directly observe or sample them across the year. Ultimately, we must consider the potential advances to be made in avian ecology through this endeavor. To this end, we highlight several specific areas of research that we believe move beyond tracking and can only be addressed by integrating direct longitudinal studies of individuals.
Dupilumab for refractory chronic rhinosinusitis in eosinophilic granulomatosis with polyangiitis
Authors: Padoan Roberto , Davanzo Federica , Iorio Luca , Saccardo Tommaso , Roccuzzo Giuseppe , Zampollo Sonny , Nicolai Piero , Doria Andrea , Ottaviano Giancarlo 
Published: October 2024

Abstract

Objectives
Eosinophilic granulomatosis with polyangiitis (EGPA) is frequently associated with refractory chronic rhinosinusitis with nasal polyps (CRSwNP), despite current treatments. Dupilumab demonstrated efficacy in the treatment of severe and uncontrolled CRSwNP, with improvements in patient-reported outcome measures (PROMs) and in objective measurements. This study aims to evaluate efficacy and safety of dupilumab in refractory CRSwNP in EGPA patients.

Methods
A prospective observational study was conducted on EGPA patients treated with dupilumab between 2021 and 2023. Patients in a phase of prolonged remission of vasculitis manifestations but still experiencing active CRSwNP were included. Clinical, biological, and rhinologic evaluations were performed, alongside with PROMs and nasal cytology. Complete response was defined by BVAS = 0 and prednisone dose ≤4 mg/day, while partial response by BVAS = 0 and prednisone dose &gt;4 mg/day.

Results
Nine EGPA patients were included. After 3 months, 55.6% achieved complete response, increasing to 83.3% at 12 months. Nasal symptoms and patient-reported outcomes improved significantly, with sustained efficacy over 12 months. An improvement in quality of life was also observed, with a significant reduction in the AAV-PRO score. Nasal cytology revealed reductions in eosinophils and neutrophils counts. Adverse events occurred in 44.4%, including hypereosinophilia in two cases, which led to dupilumab discontinuation.

Conclusion
Dupilumab is an effective treatment option for severe and refractory ENT manifestations in EGPA, as it improves symptoms, reduces inflammation, and leads to better a quality of life. However, careful patient selection and monitoring are necessary to minimize adverse events and optimize outcomes.
Unique transcriptomic profile of peripheral blood monocytes in rheumatoid arthritis-associated interstitial lung disease
Authors: Poole Jill A , Schwab Aaron , Thiele Geoffrey M , England Bryant R , Nelson Amy J , Gleason Angela , Duryee Michael J , Bailey Kristina L , Romberger Debra J , Hershberger Daniel , Van De Graaff Joel , May Sara M , Walenz Rhonda , Kramer Bridget , Mikuls Ted R 
Published: October 2024

Abstract

Objectives
Though interstitial lung disease (ILD) contributes to excess morbidity and mortality in rheumatoid arthritis (RA), RA-ILD pathogenesis remains incompletely defined. As intermediate, non-classical and suppressed CD14+ monocytes are expanded in RA-ILD, this study sought to characterize gene expression profiles of circulating monocytes in RA-ILD.

Methods
Peripheral blood mononuclear cells were collected from patients with RA without lung disease (n = 5), RA-ILD (n = 5), idiopathic pulmonary fibrosis (IPF; n = 5), and controls without lung and autoimmune disease (n = 4). RNA was extracted from CD14+ isolated monocytes and subjected to transcriptional analysis of 1365 genes. Gene enrichment and pathway analyses were performed.

Results
Unsupervised clustering grouped patients with RA-ILD together with IPF for myeloid innate genes. For fibrosis genes, patients with RA-ILD clustered independent of comparator groups. There were 103, 66 and 64 upregulated and 66, 14 and 25 downregulated genes for RA-ILD, RA, and IPF, vs controls, respectively. For RA-ILD, there was increased expression of genes involved in regulating inflammation and fibrosis (SOCS3, CECAM1, LTB4R2, CLEC7A, IRF7, PHYKPL, GBP5, RAPGEF), epigenetic modification (KDM5D, KMT2D, OGT) and macrophage activation. Top canonical pathways included macrophage differentiation-activation, IL-12, neuroinflammatory, glucocorticoid receptor and IL-27 signalling.

Conclusions
Circulating monocytes in RA-ILD patients demonstrate unique gene expression profiles, with innate immune gene features more aligned with IPF as opposed to RA in the absence of clinical lung disease, and with fibrosis gene expression that was distinct from RA and IPF. These studies are important for understanding disease pathogenesis and may provide information for future therapeutic targets in RA-ILD.
N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia
Authors: Tong Jinghui , Yang Kebing , Li Wei , Wang Leilei , Yin Yi , Zhou Yanfang , Huang Junchao , Zhang Ping , Zhao Yanli , Chen Song , Fan Hongzhen , Cui Yimin , Luo Xingguang , Tan Shuping , Wang Zhiren , Feng Wei , Tian Baopeng , Li Chiang-Shan R , Hong L Elliot , Tan Yunlong 
Published: October 2024

Abstract

Background and Hypothesis
Sensory gating deficit is considered a pathophysiological feature of schizophrenia, which has been linked to N-methyl-d-aspartate receptor (NMDAR) hypofunction as one of the potential underlying mechanisms. Here, we hypothesize that higher levels of NMDAR antibody (Ab) may contribute to the sensory gating deficits in schizophrenia.

Study Design
We enrolled 72 non-smoking inpatients with first-episode schizophrenia (FES), most of them with only a relatively short duration of exposure to antipsychotic medications, and 51 non-smoking healthy controls (HC). Sensory gating was measured by P50 evoked potentials ratio and the difference between the two stimuli in an auditory paired-stimuli paradigm and serum NMDAR Ab levels were quantified by enzyme-linked immunosorbent assay.

Study Results
The FES group showed higher serum NMDAR Ab levels [(9.23 ± 4.15) ng/mL vs. (7.08 ± 2.83) ng/mL; P = .002], higher P50 ratio (P = .002), and less P50 difference (P = .001) than HC. In partial correlation analysis, serum NMDAR Ab levels were positively correlated with the P50 ratio (r = 0.36, P = .003) and negatively with the P50 difference (r = −0.39, P = .001) in the FES group. The NMDAR Ab levels mediated the diagnosis of schizophrenia and P50 sensory gating deficits (P50 ratio and P50 difference).

Conclusions
Autoimmunity targeting NMDAR is a crucial intermediate mechanism in impaired sensory gating in patients with schizophrenia. The findings support early intervention targeting NMDAR for patients with schizophrenia.
Introduction to the Special Issue: The Lives (and Futures) of Black Children and Youth
Authors: Brooms Derrick R , Medford Marcelle M 
Published: October 2024

Abstract
As social science scholarship on Black children and youth continues to expand and to explore their experiences, there remains a need to investigate how families, communities, relationships, and social institutions impact their experiences. The theme for this special issue is inspired in part by our consideration of Black children’s and youths’ present realities and their futures. The editors of this volume are interested in creating space to analyze and theorize the radical possibilities for Black children to flourish in a world that typically ignores, marginalizes, and dismisses their plights and their promise. Privileging the agency of Black youth, the articles in this special issue provide nuanced accounts of how they make sense of many aspects of their lives and futures.
Evolution of virulence in emerging epidemics: from theory to experimental evolution and back
Authors: Benhamou Wakinyan , Blanquart François , Choisy Marc , Berngruber Thomas W , Choquet Rémi , Gandon Sylvain 
Published: October 2024

Abstract
The experimental validation of theoretical predictions is a crucial step in demonstrating the predictive power of a model. While quantitative validations are common in infectious diseases epidemiology, experimental microbiology primarily focuses on the evaluation of a qualitative match between model predictions and experiments. In this study, we develop a method to deepen the quantitative validation process with a polymorphic viral population. We analyse the data from an experiment carried out to monitor the evolution of the temperate bacteriophage λ spreading in continuous cultures of Escherichia coli. This experimental work confirmed the influence of the epidemiological dynamics on the evolution of transmission and virulence of the virus. A variant with larger propensity to lyse bacterial cells was favoured in emerging epidemics (when the density of susceptible cells was large), but counter-selected when most cells were infected. Although this approach qualitatively validated an important theoretical prediction, no attempt was made to fit the model to the data nor to further develop the model to improve the goodness of fit. Here, we show how theoretical analysis—including calculations of the selection gradients—and model fitting can be used to estimate key parameters of the phage life cycle and yield new insights on the evolutionary epidemiology of the phage λ. First, we show that modelling explicitly the infected bacterial cells which will eventually be lysed improves the fit of the transient dynamics of the model to the data. Second, we carry out a theoretical analysis that yields useful approximations that capture at the onset and at the end of an epidemic the effects of epidemiological dynamics on selection and differentiation across distinct life stages of the virus. Finally, we estimate key phenotypic traits characterizing the two strains of the virus used in our experiment such as the rates of prophage reactivation or the probabilities of lysogenization. This study illustrates the synergy between experimental, theoretical, and statistical approaches; and especially how interpreting the temporal variation in the selection gradient and the differentiation across distinct life stages of a novel variant is a powerful tool to elucidate the evolutionary epidemiology of emerging infectious diseases.
Percutaneous Electrical Stimulation Improves Chronic Knee Pain and Function
Authors: Heredia Ciuró Alejandro , Martín Núñez Javier , Calvache Mateo Andrés , López López Laura , Cebriá I Iranzo Maria dels Angels , Cabrera Martos Irene , Valenza Marie Carmen 
Published: October 2024

Objectives:
The aim of this systematic review and meta-analysis was to evaluate the effectiveness of percutaneous electrical stimulation in the modulation of pain and its implication in the function of patients with a painful knee condition.

Materials and Methods:
A search was conducted from database inception to September 2023 across PubMed, Web of Science, and Scopus databases. Randomized controlled trials were included. Two reviewers performed independent data extraction and methodologic quality assessment of the studies. Study quality was assessed using the physiotherapy evidence database Scale and the risk of bias was evaluated with the Cochrane Assessment tool.

Results:
Eight studies were included. A significant statistical effect was found (P < 0.001) for reducing pain and improving function after treatment. In addition, a significant statistical effects were identified for reducing pain (P = 0.009) and improving function (P < 0.001) after follow-up. The risk of bias was low.

Conclusion:
This review showed a positive effect of applying the percutaneous electrical stimulation for reducing pain and improving function in adults with a painful knee.
Penile and Scrotal Porokeratosis: A Single-Institution Experience
Authors: Tekin Burak , Gupta Sounak , Guo Ruifeng , Lehman Julia S. , Wieland Carilyn N. , Johnson Emma F. 
Published: October 2024

Abstract:
There is a paucity of data regarding porokeratosis confined to the penis and scrotum. We evaluated our single-institutional experience regarding this entity. We interrogated our pathology archive for all specimens from the penis or scrotum, signed out as porokeratosis between 2000 and 2022. Clinical and histopathological features were reviewed, including the number of cornoid lamella(e) per tissue profile and squamous dysplasia. Nine patients were included in the study. The median age at the time of diagnosis was 51 years. Multiple lesions were present in 3 patients. Six patients had exclusively penile involvement, whereas 2 patients had exclusively scrotal involvement. One patient had multiple lesions consistent with porokeratosis ptychotropica, extending from the scrotum to the buttocks and perineum. Clinically, a collarette of scale was noted in 3 patients and diagnosis of porokeratosis was considered in 1 patient before biopsy. Histopathologically, 2 patients exhibited multiple cornoid lamellae in the same profile and 1 patient had follicular cornoid lamellae. Focal squamous dysplasia was only present in 1 patient. Follow-up was available for 5 patients (median duration: 35 months). In 4 patients, the lesions were removed completely during the shave biopsy procedure. At the past follow-up, there were no signs of recurrence or malignant transformation to squamous cell carcinoma in any patient. Porokeratosis involving the penis and/or scrotum may be elusive to diagnosis based on clinical features alone, emphasizing the role of histopathological examination. Increased awareness of this entity may help better delineate its clinicopathological presentation and appropriate classification.
Pseudolipoblastic Perineuroma: A Rare Histologi̇c Subtype
Authors: Erdem Ozlem , Corti Barbara , Paolo Salamone Francesco , Piraccini Bianca Maria , Misciali Cosimo 
Published: October 2024

Abstract:
Pseudolipoblastic perineurioma is a very uncommon variant of extraneural perineurioma, with only a limited number of cases documented in the medical literature. The most remarkable histopathologic characteristic is the existence of vacuolated cells that closely resemble lipoblasts; besides the presence of small, spindle shaped, or epithelioid perineurial cells. In this study, we present another case of pseudolipoblastic perineurioma, predominantly characterized by the presence of vacuolated “pseudolipoblastic” cells. The immunohistochemical expression of EMA, Glut-1, claudin-1, collagen type IV, and laminin as well as S-100 negativity is essential for the diagnosis to support the perineurial origin. Simple excision is the best treatment option for these benign tumors that do not recur or metastasize. It is crucial to recognize this rare entity to differentiate it from many other tumors characterized by prominent intracytoplasmic vacuoles.
Inter-rater Reliability of Pressure Pain Threshold Between Experienced and Novice Examiners: A Case Study of 2 Educational Approaches
Authors: Wilson Abigail T. , Rothschild Carey E. 
Published: October 2024

Background and Purpose.
Pressure Pain Threshold (PPT) is used to objectively assess pain in clinical settings and is a recommended part of physical therapist education. An individual who is experienced in administering PPT will frequently train a student on the technique; however, optimal educational approaches for this instruction have not yet been identified. Therefore, the purpose of this case report is to describe 2 educational approaches (unstructured lecture and structured feedback with clinical relevance) in training 2 separate cohorts of Doctor of Physical Therapy students in PPT. The primary outcome of interest was the inter-rater reliability of PPT between an experienced and novice examiner.

Case Description.
Cohort 1 (n = 37) received a traditional lecture approach consisting of watching a prerecorded video online, an in-person lecture with demonstration of the technique, and time to practice. Cohort 2 (n = 34) received the prerecorded video online and lecture with demonstration; however, key additions included a clinical relevance discussion along with structured peer-to-peer and instructor-to-student feedback using a competency-based checklist. PPT was assessed by each student (novice examiner) and one instructor (experienced examiner). Inter-rater reliability of PPT between a novice and experienced examiner was evaluated.

Outcomes.
Inter-rater reliability improved from poor/moderate (intraclass correlation coefficient low back = 0.46 [0.16–0.68], quadriceps = 0.54 [0.26–0.73]) to good (low back = 0.84 [0.67–0.92], quadriceps = 0.90 [0.79–0.95]) after the addition of structured feedback.

Discussion.
Structured feedback from peers and instructors may be useful when learning PPT and improving inter-rater reliability, which has implications for training students within a laboratory or classroom. However, this case study would need to be replicated in an experimental design to examine the effects of varying types of feedback on learning outcomes.
Household air pollution and respiratory health in Africa: persistent risk and unchanged health burdens
Authors: Jafta Nkosana , Shezi Busisiwe , Buthelezi Minenhle , Muteti-Fana Shamiso , Naidoo Rajen N. 
Published: October 2024

Purpose of review
Despite evidence emerging from the Global Burden of Disease studies that biomass use and household air pollution are declining globally, with important positive health impacts for households in low- and middle-income countries, these trends have not been equally documented in African countries. This review describes the state of household air pollution exposure and its relationship with respiratory disease in Africa.

Recent findings
African studies on this topic are limited, and generally focus on respiratory infections. Most evidence emerge from models based on the Global Burden of Disease data, and from limited individual epidemiological studies across the continent. More than 80% of the African population is exposed to household air pollution. Women and children continue to bear the substantial burden of exposure. Evidence from limited exposure-response studies strongly points to household air pollution being the major driver of acute and chronic respiratory diseases on the continent.

Summary
Respiratory infections, particularly in children, and other chronic respiratory diseases, are strongly attributable to household air pollution. Elimination of such exposures through interventions such as cleaner fuels and preferably, electricity, is critical to improving respiratory health on the continent.