bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of an air pollution personal alert system on health service usage in a high-risk general population: a quasi-experimental study using linked data
Authors: Lyons R A , Rodgers S E , Thomas S , Bailey R , Brunt H , Thayer D , Bidmead J , Evans B A , Harold P , Hooper M , Snooks H 
Published: May 2016

BackgroundThere is no evidence to date on whether an intervention alerting people to high levels of pollution is effective in reducing health service utilisation. We evaluated alert accuracy and the effect of a targeted personal air pollution alert system, airAware, on emergency hospital admissions, emergency department attendances, general practitioner contacts and prescribed medications.MethodsQuasi-experimental study describing accuracy of alerts compared with pollution triggers; and comparing relative changes in healthcare utilisation in the intervention group to those who did not sign-up. Participants were people diagnosed with asthma, chronic obstructive pulmonary disease (COPD) or coronary heart disease, resident in an industrial area of south Wales and registered patients at 1 of 4 general practices. Longitudinal anonymised record linked data were modelled for participants and non-participants, adjusting for differences between groups.ResultsDuring the 2-year intervention period alerts were correctly issued on 208 of 248 occasions; sensitivity was 83.9% (95% CI 78.8% to 87.9%) and specificity 99.5% (95% CI 99.3% to 99.6%). The intervention was associated with a 4-fold increase in admissions for respiratory conditions (incidence rate ratio (IRR) 3.97; 95% CI 1.59 to 9.93) and a near doubling of emergency department attendance (IRR=1.89; 95% CI 1.34 to 2.68).ConclusionsThe intervention was associated with increased emergency admissions for respiratory conditions. While findings may be context specific, evidence from this evaluation questions the benefits of implementing near real-time personal pollution alert systems for high-risk individuals.
Recent Advances in Camera Planning for Large Area Surveillance
Authors: Liu Junbin , Sridharan Sridha , Fookes Clinton 
Published: May 2016

With recent advances in consumer electronics and the increasingly urgent need for public security, camera networks have evolved from their early role of providing simple and static monitoring to current complex systems capable of obtaining extensive video information for intelligent processing, such as target localization, identification, and tracking. In all cases, it is of vital importance that the optimal camera configuration (i.e., optimal location, orientation, etc.) is determined before cameras are deployed as a suboptimal placement solution will adversely affect intelligent video surveillance and video analytic algorithms. The optimal configuration may also provide substantial savings on the total number of cameras required to achieve the same level of utility.
In this article, we examine most, if not all, of the recent approaches (post 2000) addressing camera placement in a structured manner. We believe that our work can serve as a first point of entry for readers wishing to start researching into this area or engineers who need to design a camera system in practice. To this end, we attempt to provide a complete study of relevant formulation strategies and brief introductions to most commonly used optimization techniques by researchers in this field. We hope our work to be inspirational to spark new ideas in the field.
LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers
Authors: Prunier Chloé , Josserand Véronique , Vollaire Julien , Beerling Evelyne , Petropoulos Christos , Destaing Olivier , Montemagno Christopher , Hurbin Amandine , Prudent Renaud , de Koning Leanne , Kapur Reuben , Cohen Pascale A. , Albiges-Rizo Corinne , Coll Jean-Luc , van Rheenen Jacco , Billaud Marc , Lafanechère Laurence 
Published: May 2016

Abstract
LIM kinases (LIMK) are emerging targets for cancer therapy, and they function as network hubs to coordinate actin and microtubule dynamics. When LIMKs are inhibited, actin microfilaments are disorganized and microtubules are stabilized. Owing to their stabilizing effect on microtubules, LIMK inhibitors may provide a therapeutic strategy to treat taxane-resistant cancers. In this study, we investigated the effect of LIMK inhibition on breast tumor development and on paclitaxel-resistant tumors, using a novel selective LIMK inhibitor termed Pyr1. Treatment of breast cancer cells, including paclitaxel-resistant cells, blocked their invasion and proliferation in vitro and their growth in vivo in tumor xenograft assays. The tumor-invasive properties of Pyr1 were investigated in vivo by intravital microscopy of tumor xenografts. A striking change of cell morphology was observed with a rounded phenotype arising in a subpopulation of cells, while other cells remained elongated. Notably, although Pyr1 decreased the motility of elongated cells, it increased the motility of rounded cells in the tumor. Pyr1 administration prevented the growth of metastasis but not their spread. Overall, our results provided a preclinical proof of concept concerning how a small-molecule inhibitor of LIMK may offer a strategy to treat taxane-resistant breast tumors and metastases. Cancer Res; 76(12); 3541–52. ©2016 AACR.
Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320–Mediated Suppression of the Androgen Receptor
Authors: Sato Shinya , Katsushima Keisuke , Shinjo Keiko , Hatanaka Akira , Ohka Fumiharu , Suzuki Shugo , Naiki-Ito Aya , Soga Norihito , Takahashi Satoru , Kondo Yutaka 
Published: May 2016

Abstract
Targeting androgen receptor (AR) by pharmacologic intervention is one of the effective approaches for treatment of malignant prostate cancers. Histone deacetylase (HDAC) alters the epigenetic status of tumor-associated genes, including those for miRNAs (miRNA), and affects the behavior of cancers. Here, we examined the molecular effects of a HDAC inhibitor, OBP-801, on AR expression and tumor cell growth in prostate cancers. Treatment with OBP-801 efficiently suppressed cell growth of three prostate cancer lines (22Rv1, VCaP, and LNCaP), together with AR downregulation, regardless of their hormone sensitivity. Intriguingly, this effect by OBP-801 was not due to decreased transcriptional activity of the AR gene, but due to posttranscriptional regulation, namely by miRNA-mediated suppression. Among the upregulated miRNAs after OBP-801 treatment in the three prostate cancer cell lines, miR-320a, whose expression was significantly correlated with prognosis of prostate cancers (P = 0.0185), was the most closely associated with AR expression. An miR-320a mimic suppressed AR protein expression together with growth suppression, while anti-miR-320a oligonucleotide significantly abrogated the growth suppression by OBP-801 treatment. FISH analysis revealed that miR-320a was highly expressed in human normal prostate luminal cells, but was rarely expressed in prostate cancer cells. In an AR-dependent prostate tumorigenic rat model, OBP-801 treatment profoundly increased miR-320a expression and repressed prostate tumorigenesis. Our data demonstrated that OBP-801 effectively suppressed AR activity via epigenetic upregulation of miR-320a, which resulted in tumor cell growth suppression of prostate cancers. OBP-801 may be a potent AR-targeting therapeutic reagent in AR-positive prostate cancer regardless of androgen dependency. Cancer Res; 76(14); 4192–204. ©2016 AACR.
Discussions of Life Expectancy and Changes in Illness Understanding in Patients With Advanced Cancer
Authors: Epstein Andrew S. , Prigerson Holly G. , O’Reilly Eileen M. , Maciejewski Paul K. 
Published: May 2016

Purpose Accurate illness understanding enables patients to make informed decisions. Evidence of the influence of prognostic discussions on the accuracy of illness understanding by patients would demonstrate the value of discussions. Methods Recent and past oncology provider-patient discussions about prognosis/life expectancy were examined for their association with changes in illness understanding by patients. Patients (N = 178) with advanced cancers refractory to prior chemotherapy whom oncologists expected to die within 6 months were interviewed before and after a visit in which cancer restaging scan results were discussed. Illness understanding scores were the sum of four indicator variables: patient terminal illness acknowledgment, recognition of incurable disease status, knowledge of the advanced stage of the disease, and expectation to live months as opposed to years. Results Before the restaging scan visit, nine (5%) of 178 patients had completely accurate illness understanding (ie, correctly answered each of the four illness understanding questions). Eighteen patients (10%) reported only recent discussions of prognosis/life expectancy with their oncologists; 68 (38%) reported only past discussions; 24 (13%) reported both recent and past discussions; and 68 (38%) reported that they never had discussions of prognosis/life expectancy with their oncologists. After adjustment for potential confounders (ie, education and race/ethnicity), analysis identified significant, positive changes in illness understanding scores for patients in groups that reported recent only (least-squares mean change score, 0.62; 95% CI, 0.23 to 1.01; P = .002) and both recent and past (least-squares mean change score, 0.37; 95% CI, 0.04 to 0.70; P = 0.028) discussions of prognosis/life expectancy with their oncologists. Conclusion Patients with advanced cancer who report recent discussions of prognosis/life expectancy with their oncologists come to have a better understanding of the terminal nature of their illnesses.
Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial
Authors: Cortes Jorge E. , Saglio Giuseppe , Kantarjian Hagop M. , Baccarani Michele , Mayer Jiří , Boqué Concepción , Shah Neil P. , Chuah Charles , Casanova Luis , Bradley-Garelik Brigid , Manos George , Hochhaus Andreas 
Published: May 2016

Purpose We report the 5-year analysis from the phase III Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients (DASISION) trial, evaluating long-term efficacy and safety outcomes of patients with chronic myeloid leukemia (CML) in chronic phase (CP) treated with dasatinib or imatinib. Patients and Methods Patients with newly diagnosed CML-CP were randomly assigned to receive dasatinib 100 mg once daily (n = 259) or imatinib 400 mg once daily (n = 260). Results At the time of study closure, 61% and 63% of dasatinib- and imatinib-treated patients remained on initial therapy, respectively. Cumulative rates of major molecular response and molecular responses with a 4.0- or 4.5-log reduction in BCR-ABL1 transcripts from baseline by 5 years remained statistically significantly higher for dasatinib compared with imatinib. Rates for progression-free and overall survival at 5 years remained high and similar across treatment arms. In patients who achieved BCR-ABL1 ≤ 10% at 3 months (dasatinib, 84%; imatinib, 64%), improvements in progression-free and overall survival and lower rates of transformation to accelerated/blast phase were reported compared with patients with BCR-ABL1 greater than 10% at 3 months. Transformation to accelerated/blast phase occurred in 5% and 7% of patients in the dasatinib and imatinib arms, respectively. Fifteen dasatinib-treated and 19 imatinib-treated patients had BCR-ABL1 mutations identified at discontinuation. There were no new or unexpected adverse events identified in either treatment arm, and pleural effusion was the only drug-related, nonhematologic adverse event reported more frequently with dasatinib (28% v 0.8% with imatinib). First occurrences of pleural effusion were reported with dasatinib, with the highest incidence in year 1. Arterial ischemic events were uncommon in both treatment arms. Conclusion These final results from the DASISION trial continue to support dasatinib 100 mg once daily as a safe and effective first-line therapy for the long-term treatment of CML-CP.
How to use and maintain anaesthesia monitors
Authors: Taylor Susanna 
Published: May 2016

Carefully monitoring an anaesthetised patient is vital to maintaining the patient's wellbeing, and ensuring a patient's return to the same or improved physiological state that they were in prior to being anaesthetised. Although no monitor can be a substitute for a trained and attentive anaesthetist, mechanical monitors do provide information that the anaesthetist cannot know otherwise. The availability of different modes of mechanical monitors has increased for veterinary practices over recent years, and this can mean several pieces of equipment are required to be correctly set up for a single patient's anaesthetic. If monitoring equipment is not correctly used and maintained, it can become at best a waste of resources, and at worst, a risk in itself by distracting the anaesthetist from the job in hand. A lack of understanding about equipment use can also make the task of instrumenting an anaesthetised patient overwhelming, and lead to underuse of valuable resources. This article discusses how to appropriately attach commonly used monitoring modalities to a patient to ensure their best results and patient safety. It will not discuss their use further or interpretation.
Kajian Indeks Bahaya Seismik Regional Menggunakan Data Seismik Pulau Jawa Tahun 1900-2006
Authors: S Sulistiyani , Koesuma Sorja , W Nugroho Budi 
Published: May 2016

<span>It has been conducted a research about Regional Seismic Disaster Index (RSDI) in Java Island <span>by using seismic data from 1900 – 2006. RSDI is a index showing vulnerability seismic <span>disaster in an area. The hight risk area is the highest risk, the low area is the lowest risk. The <span>highest RSDI areas were Banten, Jawa Barat, and D.I Yogyakarta Provinces. While the lowest <span>RSDI areas were DKI Jakarta and Jawa Tengah Province. Deviations standard value showed <span>the moving RSDI value each region. Region with big RSDI value had high Seismic level were <span>Banten , Jawa Barat, and D.I. Yogyakarta Province.</span></span></span></span></span></span><br /></span>
The Spanish Civil War and the construction of Neorealist Greek cinema: An introductory study of Nikos Koundouros’ To Potami
Authors: Villanueva Baselga Sergio 
Published: May 2016

Abstract
The film director Nikos Koundouros is one of the most important representatives of the Neorealist Cinema that bloomed after the end of the Greek Civil War (1946–1949). This film movement was highly influenced by another conflict that took place in the previous decade: the Spanish Civil War. This brief research overview will examine, through pictorial and semiotic analyses, the film To Potami/The River by Nikos Koundouros in order to discover the extent to which this film-maker was influenced by the Spanish conflict. Therefore, this project will shed light on the study of the common historical grounds of Greece and Spain and, at the same time, on the emergent field of Southern Europe cultural studies.
Those wars are also my war: An approach to practices of postmemory in the contemporary Spanish comic
Authors: Galán Fajardo Elena , Rueda Laffond José Carlos 
Published: May 2016

Abstract
A notable feature of recent Spanish comics is their use of a viewpoint characterized by the transmission and (re)presentation of original testimonies, remade by authors who belong to later generations that had no direct experience of the Civil War. This article focuses on seven graphic works: Un largo silencio (1997), Nuestra Guerra Civil (2006), El arte de volar (2009), Los surcos del azar (2013), Las guerras silenciosas (2014), Un médico novato (2013) and Atrapado en Belchite (2015). The stories in these works recall the recent past from a common perspective, one that emphasizes the individual protagonist’s role in traumatic events. However, these narratives also employ characteristics that are specific to each story. This article reflects on the symbiosis between the shared elements of these works, and the more individual or original elements, in order to shed light on the important role of graphic narratives in the creation of spaces where memory and ‘postmemory’ can be expressed.
Screenwriting the body in Fireflies: An analysis of the devising and writing process
Authors: Dooley Kath 
Published: May 2016

Abstract
This article explores the development of corporeal themes in a screenplay by analysing the initial developmental stages of a feature film tentatively titled Fireflies as case study. In early 2015 I decided that I wanted to write a screenplay about two teenage girls’ experiences of negotiating social media and dating apps such as Tinder. In doing so I hoped to explore notions of intimacy and bodily control. My practicebased screenwriting research in this area is concerned with the way that recording observations of the female form on video and in still images can inform the representation of female agency and sexuality in a screenplay. In particular, I draw upon the approach of Virginia Pitts, who used video recordings from actor workshops to assist in the development of a short film script. This approach is underpinned by the theoretical concept of ‘kinaesthetic empathy’ as a means to form connections between writer, actors and audience. Using a reflexive methodology to mediate the screenplay development process, I respond to scripting workshops that involved two female actors, undertaken to interrogate the themes of the screenplay. These workshops involved the use of mobile phones and video cameras to record footage of bodies, which was reviewed to inform the writing of the first draft script. I examine a range of literature that presents case studies of innovate ways to ‘screen write the body’, before applying various approaches in the early development of Fireflies. Key points include a consideration of character presence and movement rather than psychology as a focus of the film narrative; and the use of screens (mobile phone and video) to write for the screen.
Deep Venous Thrombosis Associated With Inferior Vena Cava Abnormalities And Hypoplastic Kidney In Siblings
Authors: Duicu Carmen , Bucur Gabriela , Simu Iunius , Tripon Florin , Marginean Oana 
Published: May 2016

Abstract
Congenital inferior vena cava anomalies have a reduced frequency in general population, many times being an asymptomatic finding. Patients caring such anomalies are at risk to develop deep vein thrombosis. In this paper, we present 2 siblings with deep venous thrombosis and inferior vena cava abnormalities, with a symptomatic onset at similar age. The inferior vena cava abnormality was documented by an angio-CT in each case. The thrombophilic workup was negative. Patients were treated with conservative therapy: low molecular weight heparin anticoagulants converted later to oral anticoagulant with resolution of symptoms and disappearance of the thrombus. Finally, in the absence of any risk factor in a young patient admitted with deep vein thrombosis investigations to exclude inferior vena cava anomalies are mandatory.
Chemoselective synthesis of 1,2-disubstituted benzimidazoles in lactic acid without additive
Authors: Yu Zhi-Yu , Zhou Jia , Fang Qiu-Sheng , Chen Ling , Song Zhi-Bin 
Published: May 2016

AbstractLactic acid is recognised as a biocompatible medium for the chemoselective synthesis of the 1,2-disubstituted benzimidazole scaffold via a direct one-pot cyclocondensation of
Interprofessional education – structural and didactical challenges / Interprofessionelles Lehren, Lernen und Handeln – Strukturelle und didaktische Herausforderungen
Authors: Handgraaf Marietta , Dieterich Sven , Grüneberg Christian 
Published: May 2016

Abstract
After five years of experience in interprofessional education (IPE) in the Bachelor programs occupational therapy, midwifery, nursing, speech therapy, and physiotherapy at the University of Applied Sciences in Bochum (Germany), we have systematically evaluated and substantially revised our IPE concept in 2014/15. The structural and curricular embedding of IPE throughout the course of the five Bachelor programs requires the development and ongoing evolution of a binding concept for the interprofessional competence development. This concept needs to be based on a systematic reflection of current practice and sound scientific knowledge concerning interprofessional topics. Furthermore, it needs to address the promotion of competencies to act inter- and transprofessionally to enable a high quality of care (Wissenschaftsrat, 2012; Walkenhorst, 2012). Results of narrative literature reviews, structured internal discussions, interviews of experts and various internal and external evaluations have been incorporated into a new conceptual framework for IPE. It has been shown that a revision of the structure, the temporal sequences of modules and the framework to facilitate interprofessional practice are essential steps for continuous development of interprofessional education. In addition, barriers and challenges are identified and discussed. Overall, the process of development has been coordinated and accompanied continuously and successfully by an IPE committee involving different groups of representative members from the Department of Applied Health Sciences.
Norwegian Junior Football Players – Player’S Perception Of Stress According To Playing Time
Authors: Sæther Stig Arve , Aspvik Nils Petter 
Published: May 2016

Abstract
This study’s purpose was to investigate how junior football players representing a professional club experienced stressors according to there given playing time. Participants (N43) represented 3 football clubs (mean 17.4 yrs). The results showed that the players playing all matches reported a lower level of stress related to performance and future stress compared to the players playing few matches. Furthermore, evaluation and performance stress was reported higher among player given few matches compared to players playing most matches. Even so, the present study found that Norwegian junior players have a low level of stress. Based on this fact, our results suggest that coaches should focus on the players playing few matches, since they reported a higher level of stress on three dimensions, potentially impairing their development as football players.
An introductory analysis as to the influence of lower-body power on multidirectional speed in collegiate female rugby players
Authors: Lockie Robert G. , Orjalo Ashley J. , Amran Victoria L. , Davis Deshaun L. , Risso Fabrice G. , Jalilvand Farzad 
Published: May 2016

AbstractThis study investigated relationships between lower-body power, measured by a vertical jump (VJ) and standing broad jump (SBJ), with multidirectional speed in collegiate female rugby players. The rugby player data was compared to that of general team sport athletes to ascertain whether there were characteristics specific to collegiate rugby players. Multi-directional speed was measured by a 20-meter (m) sprint (0-5, 0-10, 0-20 m intervals) and 505 change-of-direction speed test. Eight rugby players and eight team sport athletes completed all tests. Spearman’s correlations calculated relationships between the VJ and SBJ with the speed tests, and stepwise multiple regressions determined whether the jump tests predicted speed performance (p≤ 0.05). For the rugby players, the VJ correlated with the 0-20 m interval (r = −0.73). The SBJ correlated with the 0-5 and 0-10 m intervals, and the left-leg 505 (r = −0.71 to −0.88), and predicted 0-5 m and left-leg 505 time (r2= 0.50-0.58). For the team sport athletes, only the VJ correlated with left-leg 505 (r = −0.80), and predicted left- and right-leg 505 times (r2= 0.61-0.69). The results suggest that horizontal power measured by a SBJ has a greater contribution to multidirectional speed in collegiate female rugby players.