bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic Mineralogical Variability along Deccan Trap Basalt Borehole (KBH07), Koyna Deep Continental Drilling Program, Western Maharashtra, India
Authors: Sangode S. J. , Venkateshwarulu M. , Mahajan Rasika , Randive Vinay 
Published: December 2017

ABSTRACT
A 1248 m long core (KBH 07, 17°18'07" N; 73°47'28.2"E, 960m above msl) drilled up to basement in the Deccan traps from Koyna region was sampled at ∼10m interval for magnetic mineralogical studies. Analysis of routine rock magnetic parameters (mass specific magnetic susceptibility: χlf, frequency dependence of susceptibility: χfd, susceptibility of anhysteretic remanance: χARM, saturation isothermal remanance: SIRM, remanance coercivty: B(0)CR, SoftIRM, HardIRM, S-Ratio, SIRM/χlf, χARM/χlf) and density (σ, gm/ cc) depicted significant higher order temporal variation. The χlf varies between 13 and 309 x 10−8m3/kg and is independent of density variation. The χARM, B(0)CR and S-Ratios indicate majority of SD-PSD ferrimagnets with episodes of MD ferrimagnetic concentration and few hard coercivity components. The giant plagioclase lath bearing (GPB) horizons show highest variability of ferrimagnetic concentration marked by anomalous peaks. Overall the variability of rock magnetic parameters independent of lava flow units suggest that the changeover in magnetic mineral concentration, composition and domain size occur at major episodes in magma composition (e.g., primary source, crustal contamination and fractional crystallization). The studied parameters are therefore examined to mark intervals of (i) magma compositional changes, (ii) zones of oxidative conditions and (iii) rapid/slow cooling intervals demanding detailed petrologic studies. We identified one I order trend, four II order cycles and eight III order cycles for the purpose of correlation. Notable peak in χlf at 650-700m, the changeover in rock magnetic parameters at ∼930 m and ∼280 m can facilitate marker intervals while several higher order variations can be adopted for high resolution correlation to other boreholes in the region. The complex variation in rock magnetic parameters independent of flow units reflect temporal magnitudes of compositional variability, cooling and emplacement history that needs detailed petro-mineralogical attempts; and the present data is useful for high order inter-core correlations under the deep drilling program.
Expanding the Analysis of Psychosocial Factors of Sexual Desire in Men
Authors: Nimbi Filippo Maria , Tripodi Francesca , Rossi Roberta , Simonelli Chiara 
Published: December 2017

Abstract

Background
The literature lacks studies of the male sex drive. Most existing studies have focused on hypoactive sexual desire disorder in coupled heterosexual men, highlighting some of the main related biological, psychological, and social factors.

Aim
To evaluate the role of selected psychological and social variables affecting male sexual desire such as quality of life, sexual function, distress, satisfaction, psychological symptoms, emotions, alexithymia, couple adjustment, sexism, cognitive schemas activated in a sexual context, sexual dysfunctional beliefs, and different classes of cognitions triggered during sexual activity about failure anticipation, erection concerns, age- and body-related thoughts, erotic fantasies, and negative attitudes toward sexuality.

Methods
A wide self-administered survey used snowball sampling to reach 298 heterosexual Italian men (age = 32.66 ± 11.52 years) from the general population.

Outcomes
13 questionnaires exploring psychological and social elements involved in sexual response were administrated: International Index of Erectile Function, Short Form 36 for Quality of Life, Beck Depression Inventory–II, Symptom Check List–90–Revised, Toronto Alexithymia Scale, Premature Ejaculation Severity Index, Sexual Distress Scale, Sexual Satisfaction Scale, Dyadic Adjustment Scale, Ambivalent Sexism Inventory, Sexual Modes Questionnaire, Sexual Dysfunctional Belief Questionnaire, and Questionnaire of Cognitive Schema Activation in Sexual Context.

Results
Results showed lack of erotic thoughts (β = −0.328), fear (β = −0.259) and desire to have a baby (β = −0.259) as the main predictors of the level of sexual desire in this group. Energy-fatigue, depression, premature ejaculation severity, sexual distress, compatibility, subjective sexual response, and sexual conservatism had a weaker effect on sexual desire. Sexual functioning (13.80%), emotional response (12.70%), dysfunctional sexual beliefs (12.10%), and negative automatic thoughts (12.00%) had more variable effects on sexual drive.

Clinical Translation
Analyzed variables could represent important factors that should be considered in the assessment of desire concerns and discussed in therapy.

Strengths and Limitations
The strength of this study is the analysis of novel psychological and social factors on male sexual desire. Recruitment and sample size do not allow generalization of the results, but some crucial points for future research and clinical practice are discussed.

Conclusion
Our findings showed that male sexual desire could be affected by many psychological and social elements. Other factors remain to be explored, in their direct and interactive effects, aiming to better explain male sexual desire functioning.
Guest Editors’ Introduction: Philosophical Contributions to Leadership Ethics
Authors: Ciulla Joanne B. , Knights David , Mabey Chris , Tomkins Leah 
Published: December 2017

ABSTRACT:This article introduces the first of two special issues on philosophical approaches to leadership ethics. In it, we show some of the ways that philosophy contributes to the study of leadership and leadership ethics. We begin with an overview of how philosophers have treated some of the ethical aspects and challenges of leadership. These include discussions of self-interest, the problem of dirty hands, responsibility, moral luck, power, gender and diversity, and spirituality. The articles in this issue draw on philosophy to explore a variety of ethical questions related to leadership and the relationships that leaders have with followers and others.
Organic Matter of Cultural Layers as a Material for Radiocarbon Dating
Authors: Zazovskaya E , Shishkov V , Dolgikh A , Alexndrovskiy A , Skripkin V , Chichagova O 
Published: December 2017

ABSTRACTThis article focuses on radiocarbon (14C) dating of the organic matter (OM) of natural-anthropogenic objects—the cultural layers (CLs) of archaeological sites. Using examples from three ancient sites located within the European part of Russia, in southern taiga and forest-steppe natural zones, we demonstrate approaches to the interpretation of 14C dating of OM derived from the organomineral material of the CLs studied. We use the term “archaeological humus” as defined as the OM formed within the CL from “anthropogenic matter” (i.e., organic residues that were produced during the past human occupation of the site) without or with negligible contribution of OM inherited from pre-anthropogenic stages of pedogenesis. The archaeological humus is formed within closed or semi-closed systems by the processes of humification and physical stabilization of OM. The use of hierarchical (from macro- to submicro-) morphological investigations at one of the sites (Gnezdovo) combined with 14C dating allowed conclusions to be drawn about the age of formation of different OM components in CLs.
Landmark lecture on interventional cardiology: interventional cardiac catheterisation for CHD: the past, present, and the future
Authors: Hijazi Ziyad M. , Kenny Damien 
Published: December 2017

AbstractCHD affects millions of patients worldwide. Interventional therapies for CHD goes back to the mid-1960s when Bill Rashkind performed balloon atrial septostomy on a cyanotic baby with transposition of the great vessels. This was followed by development of balloon catheters to perform balloon valvuloplasties and angioplasties in the early to late 1980s. Although King and Mills performed the first transcatheter closure of secundum atrial septal defect in the mid-1970s, this procedure was better realised in the mid-1990s. More intracardiac defect closures were performed in the late 1990s and early 2000. This brings us to the current era of percutaneous valve implantation as developed by Bonhoeffer. In this paper, we will discuss the past, present, and future of interventional cardiac catheterisation for CHD patients.
A PRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients
Authors: Guéant Jean-Louis , Chéry Céline , Oussalah Abderrahim , Nadaf Javad , Coelho David , Josse Thomas , Flayac Justine , Robert Aurélie , Koscinski Isabelle , Gastin Isabelle , Filhine-Tresarrieu Pierre , Pupavac Mihaela , Brebner Alison , Watkins David , Pastinen Tomi , Montpetit Alexandre , Hariri Fadi , Tregouët David , Raby Benjamin A , Chung Wendy K. , Morange Pierre-Emmanuel , Froese D. Sean , Baumgartner Matthias R. , Benoist Jean-François , Ficicioglu Can , Marchand Virginie , Motorin Yuri , Bonnemains Chrystèle , Feillet François , Majewski Jacek , Rosenblatt David S. 
Published: December 2017

AbstractTo date, epimutations reported in man have been somatic and erased in germlines. Here, we identify a cause of the autosomal recessive cblC class of inborn errors of vitamin B12 metabolism that we name “epi-cblC”. The subjects are compound heterozygotes for a genetic mutation and for a promoter epimutation, detected in blood, fibroblasts, and sperm, at the MMACHC locus; 5-azacytidine restores the expression of MMACHC in fibroblasts. MMACHC is flanked by CCDC163P and PRDX1, which are in the opposite orientation. The epimutation is present in three generations and results from PRDX1 mutations that force antisense transcription of MMACHC thereby possibly generating a H3K36me3 mark. The silencing of PRDX1 transcription leads to partial hypomethylation of the epiallele and restores the expression of MMACHC. This example of epi-cblC demonstrates the need to search for compound epigenetic-genetic heterozygosity in patients with typical disease manifestation and genetic heterozygosity in disease-causing genes located in other gene trios.
Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors
Authors: Chen Ye , Ho Joanne M. L. , Shis David L. , Gupta Chinmaya , Long James , Wagner Daniel S. , Ott William , Josić Krešimir , Bennett Matthew R. 
Published: December 2017

AbstractOne challenge for synthetic biologists is the predictable tuning of genetic circuit regulatory components to elicit desired outputs. Gene expression driven by ligand-inducible transcription factor systems must exhibit the correct ON and OFF characteristics: appropriate activation and leakiness in the presence and absence of inducer, respectively. However, the dynamic range of a promoter (i.e., absolute difference between ON and OFF states) is difficult to control. We report a method that tunes the dynamic range of ligand-inducible promoters to achieve desired ON and OFF characteristics. We build combinatorial sets of AraC-and LasR-regulated promoters containing −10 and −35 sites from synthetic and Escherichia coli promoters. Four sequence combinations with diverse dynamic ranges were chosen to build multi-input transcriptional logic gates regulated by two and three ligand-inducible transcription factors (LacI, TetR, AraC, XylS, RhlR, LasR, and LuxR). This work enables predictable control over the dynamic range of regulatory components.
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
Authors: Lucas Sébastien , Omata Yasunori , Hofmann Jörg , Böttcher Martin , Iljazovic Aida , Sarter Kerstin , Albrecht Olivia , Schulz Oscar , Krishnacoumar Brenda , Krönke Gerhard , Herrmann Martin , Mougiakakos Dimitrios , Strowig Till , Schett Georg , Zaiss Mario M. 
Published: December 2017

AbstractMicrobial metabolites are known to modulate immune responses of the host. The main metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain fatty acids (SCFA), affect local and systemic immune functions. Here we show that SCFA are regulators of osteoclast metabolism and bone mass in vivo. Treatment of mice with SCFA as well as feeding with a high-fiber diet significantly increases bone mass and prevents postmenopausal and inflammation-induced bone loss. The protective effects of SCFA on bone mass are associated with inhibition of osteoclast differentiation and bone resorption in vitro and in vivo, while bone formation is not affected. Mechanistically, propionate (C3) and butyrate (C4) induce metabolic reprogramming of osteoclasts resulting in enhanced glycolysis at the expense of oxidative phosphorylation, thereby downregulating essential osteoclast genes such as TRAF6 and NFATc1. In summary, these data identify SCFA as potent regulators of osteoclast metabolism and bone homeostasis.
Importance of the 1+7 configuration of ribonucleoprotein complexes for influenza A virus genome packaging
Authors: Noda Takeshi , Murakami Shin , Nakatsu Sumiho , Imai Hirotaka , Muramoto Yukiko , Shindo Keiko , Sagara Hiroshi , Kawaoka Yoshihiro 
Published: December 2017

AbstractThe influenza A virus genome is composed of eight single-stranded negative-sense RNAs. Eight distinct viral RNA segments (vRNAs) are selectively packaged into progeny virions, with eight vRNAs in ribonucleoprotein complexes (RNPs) arranged in a specific “1+7” pattern, that is, one central RNP surrounded by seven RNPs. Here we report the genome packaging of an artificially generated seven-segment virus that lacks the hemagglutinin (HA) vRNA. Electron microscopy shows that, even in the presence of only seven vRNAs, the virions efficiently package eight RNPs arranged in the same “1+7” pattern as wild-type virions. Next-generation sequencing reveals that the virions specifically incorporate host-derived 18S and 28S ribosomal RNAs (rRNAs) seemingly as the eighth RNP in place of the HA vRNA. These findings highlight the importance of the assembly of eight RNPs into a specific “1+7” configuration for genome packaging in progeny virions and suggest a potential role for cellular RNAs in viral genome packaging.
Incomplete prophage tolerance by type III-A CRISPR-Cas systems reduces the fitness of lysogenic hosts
Authors: Goldberg Gregory W. , McMillan Elizabeth A. , Varble Andrew , Modell Joshua W. , Samai Poulami , Jiang Wenyan , Marraffini Luciano A. 
Published: December 2017

AbstractCRISPR–Cas systems offer an immune mechanism through which prokaryotic hosts can acquire heritable resistance to genetic parasites, including temperate phages. Co-transcriptional DNA and RNA targeting by type III-A CRISPR–Cas systems restricts temperate phage lytic infections while allowing lysogenic infections to be tolerated under conditions where the prophage targets are transcriptionally repressed. However, long-term consequences of this phenomenon have not been explored. Here we show that maintenance of conditionally tolerant type III-A systems can produce fitness costs within populations of Staphylococcus aureus lysogens. The fitness costs depend on the activity of prophage-internal promoters and type III-A Cas nucleases implicated in targeting, can be more severe in double lysogens, and are alleviated by spacer-target mismatches which do not abrogate immunity during the lytic cycle. These findings suggest that persistence of type III-A systems that target endogenous prophages could be enhanced by spacer-target mismatches, particularly among populations that are prone to polylysogenization.
The introduction of genetically modified microorganisms designed for rhizoremediation induces changes on native bacteria in the rhizosphere but not in the surrounding soil
Authors: de Cárcer Daniel Aguirre , Martín Marta , Mackova Martina , Macek Thomas , Karlson Ulrich , Rivilla Rafael 
Published: December 2017

Abstract
A 168-day microcosms experiment was used to assess the possible functional and structural shifts occurring in the bacterial community of a site with a historical record of polychlorinated biphenyl (PCB) contamination, after the introduction of plants whose roots have been inoculated with genetically modified (GM) microorganisms, designed for rhizoremediation. Salix sp. plants were inoculated with two different GM Pseudomonas fluorescens strains or with their parental wild-type strain. Both bulk soil and rhizosphere samples were analyzed. Physiological profiles based on 31 ecologically relevant carbon sources were used to detect differences in bacterial community functions. The community structure of eubacteria, α and β-proteobacteria, actinobacteria and acidobacteria communities were analyzed via a polymerase chain reaction–thermal gradient gel electrophoresis (TGGE) approach. The introduced transgenes had no effect on the function and structure of the bacterial community in bulk soil, although they enhanced biodegradation of PCBs as determined by chemical analysis. However, the transgenes effected the development of functionally and genetically distinct bacterial communities in the rhizosphere. Moreover, structural and functional differences were detected between planted and unplanted soils and between soil and rhizosphere samples. In the case of the different group-specific structures studied, differences were observed between groups because of time-dependant shifts, rhizosphere effect and bacterial strain introduced.
Juvenile Idiopathic Arthritis Associated with Combined JP–HHT Syndrome: A Novel Phenotype Associated with a Novel Variant in SMAD4
Authors: Britton Jacquelyn , Murphy Anne , Sule Sangeeta , Mitchell Sally , Takemoto Clifford , Collaco Joseph , Karnsakul Wikrom , Cuffari Carmelo , Dietz Edith , Bodurtha Joann , Bishop Juliet 
Published: December 2017

AbstractJuvenile polyposis (JP) syndrome is characterized by multiple hamartomatous polyps of the gastrointestinal tract. Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia characterized by telangiectasia in the skin, mucous membranes, and arteriovenous malformations in other organs. Individuals with JP–HHT syndrome have variable features of both rare disorders, attributed to heterozygous mutations in the SMAD4 gene. Systemic juvenile idiopathic arthritis (JIA) is a severe, chronic disease marked by arthritis and systemic inflammation for which the cause remains unknown. JIA has never been described in association with SMAD4-related disease. We describe a case of JP–HHT syndrome with a novel SMAD4 variant, c.1052A > T (p.D351V), in which the child also had JIA manifestation.
The Microsurgical Relationships between Internal Carotid-Posterior Communicating Artery Aneurysms and the Skull Base
Authors: Komune Noritaka , Tsuchimochi Ryosuke , Kai Yasutoshi , Matsumoto Kenichi , Haga Sei , Inoue Takuya , Matsuo Satoshi 
Published: December 2017

Objective This study aimed to review the anatomical and clinical characteristics of internal carotid-posterior communicating artery (IC-PC) aneurysms, especially those located close to the skull base.
Methods The microsurgical anatomy around the posterior communicating artery (PComA) was examined in a dry skull and five formalin-fixed human cadaveric heads. The clinical characteristics of 37 patients with 39 IC-PC aneurysms, who were treated microsurgically between April 2008 and July 2016, were retrospectively reviewed.
Results The anterior clinoid process (ACP), as well as the anterior petroclinoidal dural fold (APF), which forms part of the oculomotor triangle, are closely related to the origin of the PComA. Among the 39 IC-PC aneurysms, anterior clinoidectomy was performed on 4 (10.3%) and a partial resection of the APF was performed on 2 (5.1%). Both of these aneurysms projected inferior to the tentorium, or at least part of the aneurysm's dome was inferior to the tentorium.
Conclusion Proximally located IC-PC aneurysms have an especially close relationship with the ACP and APF. We should be familiar with the anatomical relationship between IC-PC aneurysms and the structures of the skull base to avoid hazardous complications.
Bone-Patellar Tendon-Bone Autograft versus Hamstring Tendon Autograft for Anatomical Anterior Cruciate Ligament Reconstruction with Three-Dimensional Validation of Femoral and Tibial Tunnel Positions
Authors: Inui Hiroshi , Yamagami Ryota , Shirakawa Nobuyuki , Kawaguchi Kohei , Nakagawa Takumi , Tanaka Sakae , Taketomi Shuji 
Published: December 2017

AbstractThe purpose of this retrospective study was to first compare the clinical outcome of anatomical double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) with hamstring tendon (HT) autografts and anatomical rectangular tunnel ACLR with bone-patellar tendon-bone (BPTB) autografts. Secondly, we aimed to demonstrate the quantitative locations of the femoral and tibial tunnel apertures using postoperative three-dimensional computed tomography (3D CT). Twenty-five patients underwent anatomical rectangular tunnel ACLR using BPTB grafts (Group B) and 23 patients underwent anatomical DB ACLR using HT grafts (Group H). All patients underwent subjective postoperative evaluations using the Lysholm score and Knee Injury and Osteoarthritis Outcome Score. Patients also underwent objective evaluations by the International Knee Documentation Committee score, the Lachman test, the pivot-shift test, and range of motion. In addition, we quantitatively assessed anterior knee stability using a KneeLax3 arthrometer and thigh strength. All evaluations except for thigh strength were assessed for a minimum 2 years of follow-up period. Femoral and tibial tunnel aperture locations were quantitatively evaluated postoperatively using 3D CT images in all patients. BPTB grafts showed significantly better anterior knee stability than HT grafts (0.1 mm versus 1.1 mm, p = 0.01), although there were no significant differences in other objective and all subjective evaluations between the two graft types. Morphometric analysis of femoral and tibial tunnel locations revealed that the two procedures were based on the same anatomical concept. In conclusion, BPTB grafts showed significantly better anterior knee stability than HT grafts, although no significant differences in other objective evaluations and all subjective evaluations were detected between the two graft types in anatomical ACLR. Additional 3D CT data validated the anatomical concepts of these two procedures.
Potential Relationship between Passive Plantar Flexor Stiffness and Running Performance
Authors: Ueno Hiromasa , Suga Tadashi , Takao Kenji , Tanaka Takahiro , Misaki Jun , Miyake Yuto , Nagano Akinori , Isaka Tadao 
Published: December 2017

Abstract
The present study aimed to determine the relationship between passive stiffness of the plantar flexors and running performance in endurance runners. Forty-eight well-trained male endurance runners and 24 untrained male control subjects participated in this study. Plantar flexor stiffness during passive dorsiflexion was calculated from the slope of the linear portion of the torque-angle curve. Of the endurance runners included in the present study, running economy in 28 endurance runners was evaluated by measuring energy cost during three 4-min trials (14, 16, and 18 km/h) of submaximal treadmill running. Passive stiffness of the plantar flexors was significantly higher in endurance runners than in untrained subjects. Moreover, passive plantar flexor stiffness in endurance runners was significantly correlated with a personal best 5000-m race time. Furthermore, passive plantar flexor stiffness in endurance runners was significantly correlated with energy cost during submaximal running at 16 km/h and 18 km/h, and a trend towards such significance was observed at 14 km/h. The present findings suggest that stiffer plantar flexors may help achieve better running performance, with greater running economy, in endurance runners. Therefore, in the clinical setting, passive stiffness of the plantar flexors may be a potential parameter for assessing running performance.