bluuebunny/crossref_metadata_2025_split huggingface dataset:
The oral intake of specific Bioactive Collagen Peptides (BCP) improves gait and quality of life in canine osteoarthritis patients—A translational large animal model for a nutritional therapy option
Authors: Dobenecker Britta , Böswald Linda Franziska , Reese Sven , Steigmeier-Raith Stephanie , Trillig Lukas , Oesser Steffen , Schunck Michael , Meyer-Lindenberg Andrea , Hugenberg Jutta 
Published: September 2024

Objective
Osteoarthritis (OA) is the most common joint disorder in humans and dogs. Due to its chronic progressive nature, the predominant clinical signs after a certain point are pain and immobility. The similar pathogenesis allows conclusions to be drawn from canine to human OA. Current treatments are limited and often attempt to treat OA symptoms rather than improve joint structure and function. Collagen hydrolysates as oral supplements are a promising therapeutic option to achieve this advanced therapeutic aim in both species. The effects of oral supplementation were therefore investigated in canine OA patients.

Method
In a systematic, placebo-controlled, double-blind interventional study in 31 dogs with naturally occurring OA, the efficacy of oral supplementation of specific bioactive collagen peptides (BCP) was tested in comparison to the approved combination of the active substances omega-3 fatty acids and vitamin E. The dogs were examined on a horizontal treadmill with 4 integrated piezoelectric force plates at the beginning and end of a twelve-week test period. At both points, the owners completed a specific questionnaire containing the validated Canine Brief Pain Inventory (CBPI) and the dogs were fitted with accelerometers to record total daily activity data.

Results
Only the oral supplementation of BCP resulted in a significant improvement of several kinetic parameters measured using a force-plate fitted treadmill, and the quality of life assessed by CBPI, while accelerometry was unaffected by the intervention.

Conclusion
The results of this three-month BCP supplementation study using objective measurement parameters in dogs with naturally occurring OA demonstrate an efficacy, suggesting the therapeutic use of BCP in canine OA patients and demonstrating the relevance of this collagen hydrolysate formulation for the treatment of OA in human patients as well.
Real-World Effectiveness and Use of Dupilumab in Eosinophilic Esophagitis
Authors: Russin Michelle , Chen Joan , Rubenstein Joel H. , Chang Joy W. 
Published: September 2024

INTRODUCTION:
Dupilumab, the first US Food and Drug Administration–approved treatment for eosinophilic esophagitis (EoE), lacks real-world data on use and effectiveness.

METHODS:
We conducted a retrospective cohort study of 70 patients with EoE prescribed dupilumab, comparing prescriber type, indication, follow-up, and response.

RESULTS:
Indications varied with gastroenterologists commonly prescribing for treatment-refractory cases and allergists as first-line therapy. Endoscopic assessment was lacking in 25.9%, but those with follow-up showed high histologic remission (92.3% first-line and 85% previous treatment failure).

DISCUSSION:
Dupilumab demonstrates effectiveness across EoE severity, including milder disease without previous treatment failure. Improving follow-up and assessing cost-effectiveness will help clarify its role in the treatment algorithm.
NIKAH BEDA AGAMA: Perspektif Aktifis Jaringan Islam Liberal (JIL)
Authors: Harsono Muhamad 
Published: September 2024

Dewasa ini, di Indonesia penikahan beda agama merupakan fenomena di kalangan selebritis, masyarakat awam, bahkan aktivis dialog antar agama dan kaum agamawan terdidik. Akhir-akhir ini, Paramadina, sebuah lembaga kajian dan kursus intensif agama Islam yang didirikan oleh Nurcholis Madjid menjadi tuan rumah dan mengakui pernikahan pasangan beda agama antara Rudi Pratono (Islam) dan Ana Maria Saraswati (Katholik). Pada bulan Juni 2004, seorang aktifis yang bernama Ahmad Nurcholis (aktifis ICRP yang beragama Islam) menikahi Ang Mei Yong seorang Konghucu. Tulisan ini coba mengetengahkan perspektif Aktifis JIL (Jaringan Islam Liberal) tentang pernikahan beda agama tersebut.
KONTRIBUSI PEMIKIRAN QASIM AMIN DALAM PEMBARUAN HUKUM KELUARGA ISLAM
Authors: Bahri Syaiful 
Published: September 2024

This paper attempts to discuss two things. First, the history of family law reform in the Muslim world. Second, Qasim Amin thoughtful contributions to the process of family law reform happening in the Muslim world. The process of family law reform in the Muslim world is not born out naturally. The reform was born due to the fact that the conventional family law is not in accordance with the challenges of the times. The fundamental purpose of Islamic family law reform is to raise the status of women. Even so, the contribution of Qasim Amin in the process of family law reform happening in the Muslim world can be traced from his idea of social reform project (al-Is}la>h} al-ijtima>i). For Amin, the process of social reform would only be successful if there is a family law hasbeen updated and brought in line with the demands of the times. The ideas of family law reform, primarily on three crucial themes, marriage, polygamy, and divorce, have been said in Amin’s first work, Tah}ri>r al-mar’ah (1899).[Tulisan ini mencoba mendiskusikan dua hal. Pertama, sejarah pembaruan hukum keluarga di dunia Muslim. Kedua, kontribusi pemikiran Qasim Amin terhadap proses pembaruan hukum keluarga yang terjadi di dunia Muslim. Proses pembaruan hukum keluarga di dunia Muslim tidak lahir dariruang kosong. Pembaruan tersebut lahir atas adanya kenyataan bahwa hukum keluarga konvensional sudah tidak sesuai dengan tantangan zaman. Sedang tujuan fundamental dari pembaruan hukum keluarga Islam adalah untuk mengangkat status perempuan. Pun demikian, kontribusi Qasim Amin dalam proses pembaruan hukum keluarga yang terjadi di dunia Muslim bisa dilacak dari proyek reformasi sosial (al-Is}la>h} al-Ijtima>’i) yang beliau gagas. Bagi Amin, proses reformasi sosial hanya akan berhasil jika hukum keluarga yang ada sudah diperbarui dan diselaraskan dengan tuntutan zaman. Ide-ide pembaruan dalam hukum keluarga, utamanya terhadap tiga tema krusial, perkawinan, poligami, dan perceraian, sudah Amin cetuskan dalam karya pertamanya, Tah}ri>r al-Mar‘ah (1899).]
TEORI RI’ÂYAH AL-MASLAHAH ÂT-TUFI DAN APLIKASINYA DALAM MENAKAR PROBLEMATIKA IHDAD
Authors: Milati Arifah 
Published: September 2024

Ri’a>yah al-mas}lah}ah is the purpose of the law. This theory by Najm ad-Di>n at}-T}u>fi> serve as the first legal considerations in mu’a>malah. Mas}lah}ah considered independent without the support of certain nas even though its meaning is contained in the passages. The theory is clearly different from the theory of the clergy in general. One of the standard system of rules of classical fiqh books to the book of contemporary jurisprudence is ih}da>d. The concept is unique and has been codified in the books of fiqh seems to be the dogmatic rules of grammar can not be questioned over its validity. The concept ih}da>d has been standardized and codified the scholars in their books, the case is not a serious problem when associated with the position of women in the previous era, but if you do a how to find a solution as a meeting point in order to avoid collisions between the ideas that have been classical scholars formulated with the real conditions of life of modern women in the public sector. [Ri’a>yah al-mas}lah}ah adalah tujuan hukum. Teori ini oleh Najm ad-Di>n at}-T}u>fi> dijadikan sebagai pertimbangan hukum pertama dalam bidang mu’a>malah. Mas}lah}ah dianggap independen tanpa didukung nas} tertentu walaupun maknanya sudah terkandung di dalam nas}. Teori tersebut jelasberbeda dengan teori ulama pada umumnya. Salah satu aturan sistem yang baku dari kitab-kitab fikih klasik hingga kitab fikih kontemporer adalah ih}da>d. Konsep yang khas dan sudah dikodifikasi dalam kitab-kitab fikih sepertinya merupakan tata aturan dogmatik yang tidak bisa dipertanyakanulang validitasnya. Konsep ih}da>d telah dibakukan dan dikodifikasikan para ulama dalam kitabkitabnya, kasus tersebut tidak menjadi problem serius bila dikaitkan dengan posisi perempuan pada era terdahulu, namun jika demikian adanya bagaimana mencari solusi sebagai titik temu agar tidak terjadi benturan antara ide yang telah dirumuskan para ulama klasik dengan kondisi riil berupakehidupan perempuan modern di sektor publik.]
KONSEP TALAK: Versus Situs www. darussalaf.or.id dan Undang- Undang Perkawinan di Indonesia
Authors: Fakhria Sheila 
Published: September 2024

This paper discusses divorce in the Internet by focusing on the study of Islam is one of the sites www.darussalaf.or.id. An active site that publishes material and also Islamic marriage law required communities, one divorce. On site www. darussalaf.or.id explained that divorce is the husband full rights in conditions of legal age, intelligent, mumayyiz who understand what it does. In addition, the site also explains that a wife is not allowed to ask for divorce without reason Sharai, otherwise the wife is allowed to ask to split up with her husband on the grounds Sharai them if she hates moral ugliness, religion, husband’s physical, and worried not be able to enforce the rights that are required fulfilled when her husband live with her. Therefore, it is necessary to study the extent to which the relevance of the concept of the validity of a divorce between sites www.darussalaf.or.id and marriage laws in Indonesia.[Tulisan ini membahas tentang talak dalam internet dengan memfokuskan kajian pada salah satu situs islam yaitu www.darussalaf.or.id. Sebuah situs yang aktif mempublikasikan materi keislaman dan juga hukum perkawinan yang dibutuhkan masyarakat, salah satunya talak. Pada situs www.darussalaf.or.id dijelaskan bahwa talak merupakan hak sepenuhnya suami yang dalam kondisibaligh, berakal, mumayyiz yang mengerti dengan apa yang dilakukan. Selain itu, situs ini juga menjelaskan bahwa seorang istri tidak diperkenankan meminta cerai tanpa alasan yang syar’i, sebaliknya seorang istri diperbolehkan meminta untuk berpisah dengan suaminya dengan alasan syar’i diantaranya jika dia membenci kejelekan akhlak, agama, atau fisik suaminya, serta khawatir tidak mampu menegakkan hak-hak suaminya yang wajib ditunaikannya ketika hidup bersamanya. Oleh karena itu perlu dikaji tentang sejauh mana relevansi konsep keabsahan talak antara situs www.darussalaf.or.id dan undang-undang perkawinan di Indonesia.]
Effects of Collocational Congruency, Frequency and L2 Proficiency on the Processing of English Adjective-Noun Collocations
Authors: Yang Lianrui , Zhang Qun , Li Ni , Chen Ying 
Published: September 2024

Abstract
The present study investigates the effects of congruency and frequency on adjective-noun collocational processing for Chinese learners of English at two proficiency levels based on the data obtained in an online acceptability judgment task. The subject pool of this research included 60 English majors studying at a university in China; 30 were selected as a higher-proficiency group and 30 as a lower-proficiency group according to their Vocabulary Levels Test (Schmitt et al., 2001) scores and their self-reported proficiency in English. The experimental materials were programmed to E-prime 2.0 and included six types of collocations: (1) 15 high-frequency congruent collocations, (2) 15 low-frequency congruent collocations, (3) 15 high-frequency incongruent collocations, (4) 15 low-frequency incongruent collocations, (5) 15 Chinese-only items, and (6) 75 unrelated items for baseline data. The collected response times (RTs) and accuracy rates data were statistically analyzed by the use of an ANOVA test and pairwise comparisons through SPSS 16.0 software. The results revealed that: (1) the adjective-noun collocational processing of Chinese English learners is influenced by collocational frequency, congruency and L2 proficiency; (2) the processing time is affected by the interaction of congruency and frequency; and (3) the interactive effect of L2 proficiency in conjunction with congruency and frequency also influences the processing quality.
Text Difficulty, Working Memory Capacity and Mind Wandering During Chinese EFL Learners’ Reading
Authors: Gao Xianli , Li Li 
Published: September 2024

Abstract
This experimental study investigated how text difficulty and different working memory capacity (WMC) affected Chinese EFL learners’ reading comprehension and their tendency to engage in task-unrelated thoughts, that is, mind wandering (MW), in the course of reading. Sixty first-year university non-English majors participated in the study. A two-factor mixed experimental design of 2 (text difficulty: difficult and simple) × 2 (WMC: high/large and low/small) was employed. Results revealed that 1) the main and interaction effects of WMC and text difficulty on voluntary MW were significant, whereas those on involuntary MW were not; 2) while reading the easy texts, the involuntary MW of high-WMC individuals was less frequent than that of low-WMC ones, whereas while reading the difficult ones, the direct relationship between WMC and involuntary MW was not found; and that 3) high-WMC individuals had a lower overall rate of MW and better reading performance than low-WMC individuals did, but with increasing text difficulty, their rates of overall MW and voluntary MW were getting higher and higher, and the reading performance was getting lower and lower. These results lend support to WM theory and have pedagogical implications for the instruction of L2 reading.
A Cognitive Study on Politeness Intention Processing and Its Association with Pragmatic Failure in Cross-Cultural Communication
Authors: Yan Rong , Feng Tengfei , Zare Samad 
Published: September 2024

Abstract
Although a large number of studies have focused on various aspects of politeness, very little is known about how politeness intention is activated cognitively during verbal communication. The present study aims to explore the cognitive mechanism of politeness intention processing, and how it is related to pragmatic failure during cross-cultural communication. Using 30 Chinese EFL university students who were instructed to finish a probe word judgment task with 96 virtual scenarios, the results indicate that within both mono- and cross-cultural contexts, the response time in the experimental scenarios was significantly slower than that of the filler scenarios. This suggests that politeness intention was activated while understanding the surface meaning of the conversation; however, the EFL learners could not completely avoid the negative transfer of their native politeness conventions when they were comprehending the conversational intention of the target language. Furthermore, no significant differences in response time were found between the groups with high and low English pragmatic competence, illustrating that transferring the pragmatic rules and principles into cross-cultural communication skills was more cognitively demanding. Overall, this study adds to the literature on politeness research and provides some implications for foreign language pragmatic instructions.
Systematizing Teacher Development: A Review of Foreign Language Teacher Learning
Authors: Zeng Guang 
Published: September 2024

Abstract
Foreign language teaching practice is developing rapidly, but research on foreign language teacher learning is currently relatively fragmented and unstructured. The book Foreign Language Teacher Learning, written by Professor Kang Yan from Capital Normal University, published in September 2022, makes a systematic introduction to foreign language teacher learning, which to some extent makes up for this shortcoming. Her book presents the lineage of foreign language teacher learning research at home and abroad, analyzes both theoretical and practical aspects, reviews the cuttingedge research results, and foresees the future development trend, painting a complete research picture for researchers in the field of foreign language teaching and teacher education as well as front-line teachers interested in foreign language teacher learning. This is an important inspiration for conducting foreign language teacher learning research in the future. And this paper makes a review of the book from aspects such as its content, major characteristics, contributions and limitations.
How does using an AR learning environment affect student learning of a radical substitution mechanism?
Authors: Bullock Martin , Huwer Johannes , Graulich Nicole 
Published: September 2024

Abstract
As the use of augmented reality (AR) in educational settings grows, it becomes increasingly important to understand how to use AR in classrooms. Here, we present an AR learning environment that we designed for teaching an organic chemistry reaction mechanism in high school chemistry classes. This new environment was tested in six tenth-grade chemistry classes (upper secondary) taught by five different teachers in three different schools over the course of five months and evaluated for effectiveness. Students completed knowledge tests before and after they used the AR learning environment to test their learning gain, and surveys to measure their acceptance of the technology, the cognitive load they experienced, and their attitude toward the use of AR to learn the mechanism for radical substitution. Analysis shows that the knowledge posttest scores were significantly higher than the pretest scores (p < 0.001), with a large effect size (r = 0.8). Student responses showed acceptance of the technology, experience of low extraneous cognitive load, and a positive attitude toward the use of AR to learn this reaction mechanism. These findings indicate that this AR learning environment can be used to teach the mechanism of radical substitution to tenth-grade students in introductory high school chemistry courses.
Vitamin D assay and supplementation: still debatable issues
Authors: Plebani Mario , Zaninotto Martina , Giannini Sandro , Sella Stefania , Fusaro Maria , Tripepi Giovanni , Gallieni Maurizio , Herrmann Markus , Cozzolino Mario 
Published: September 2024

Abstract
Over the last decades, in addition to the improvement of pathophysiological knowledge regarding the role and mechanisms of action of vitamin D, there has been a progressive advancement in analytical technologies for its measurement, as well as in methodological standardization. A significant number of scientific works, meta-analyses, and guidelines have been published on the importance of vitamin D and the need for supplementation in deficient individuals. However, it appears necessary to clarify the fundamental elements related to the measurement of vitamin D (both at the strictly analytical and post-analytical levels) and the scientific evidence related to the efficacy/safety of supplementation. In particular, there is a need to discuss current recommended levels for deficiency, insufficiency and possible toxicity in the light of evidence from standardization projects. Additionally, given the important interrelations between vitamin D, parathyroid hormone (PTH), and fibroblast growth factor-23 (FGF23), the analytical issues and clinical utility of these biomarkers will be discussed.
Spectrally efficient DWDM system using DQPSK modulation
Authors: Prakash Deepthi , Managuli Manjunath 
Published: September 2024

Abstract
DWDM technology is gaining popularity in fiber-optic communication due to high-speed transmission channel capacity demands. The adoption of this system has been driven by this demand. Researchers focus on optimizing data transmission parameters within channel characteristics for maximum performance. The signal’s form typically influences the optical channel capacity, the guiding medium’s dispersive and non-linear characteristics, and interference from multiple sources. This study investigates how efficient modulated systems control linear and non-linear impairments in optical channel capacity due to high data rates transmitted over optical communication networks, aiming to circumvent current issues. The selection of pulse shape and modulation format is crucial for an effective DWDM optical communication system due to the rigorous specifications of the optical channel. Modulation formats like intensity and phase have become viable network design technologies, allowing for network creation that operates to the designer’s satisfaction. This academic study examines the theoretical properties of various models used to analyze and recreate high-speed optical communication links, aiming to understand the impact of system components and modulation techniques.
Estrogen-insensitivity syndrome (EIS) in a female adolescent patient – a case report
Authors: Soltani Akbar , Fatollahzadeh Mahdieh , Izadi Pantea , Rad Zahra Abbaspour , Tavassol Zahra Hoseini , Pajavand Hamid , Amini Masoomeh , Hasani-Ranjbar Shirin 
Published: September 2024

Abstract

Objectives
Estrogen insensitivity syndrome (EIS) is a rare genetic disorder characterized by an autosomal dominant inheritance pattern. The disease results from a pathogenic variant in the ESR1 (estrogen receptor 1) gene, leading to estrogen resistance in individuals possessing the 46, XX karyotype. The alpha receptor, which is predominant in peripheral tissues, is responsible for estrogen action. As a result, pathogenic variants in the ESR1 gene can cause various disorders, such as changes in secondary sexual characteristics, increased concentrations of estrogen and gonadotropins, and delayed bone maturation.

Case presentation
Here, the case of a 13-year-old girl, with high estrogen and gonadotropin concentrations, lack of breast development, uterine growth and delayed bone age is described. The patient’s parents were related. She was found to have a homozygous pathogenic variant in the ESR1 gene located on chromosome 6q25, which interferes with estrogen signaling.

Conclusions
This case supports that disruption of ESR1 causes profound estrogen resistance in females.
Mineralocorticoid receptor antagonist monotherapy in pediatric non-classical 11β-hydroxylase deficiency
Authors: Kennedy Elaine C. , Stack Maria , Carolan Eirin , Durkan Maeve , Joyce Caroline M. , Hawkes Colin P. 
Published: September 2024

Abstract

Objectives
Congenital adrenal hyperplasia (CAH) is an uncommon genetic disorder which affects cortisol production in the adrenal glands. It is usually treated with glucocorticoids. We present a case of non-classical CAH caused by the partial deficiency of 11 beta-hydroxylase (11βOH) which was treated with aldosterone antagonist (eplerenone) monotherapy.

Case presentation
An adolescent male was diagnosed with 11 beta-hydroxylase deficiency (11βOHD) at 13 years of age when he presented with hypertension, fatigue and headaches. He was initially treated with glucocorticoids, but requested an alternative therapy. Eplerenone was commenced at 25 mg with subsequent dose increases to 100 mg daily. His hypertension was controlled on this regimen, achieving a 24 h average blood pressure of 124/81 mmHg.

Conclusions
CAH caused by 11βOHD is a known cause of hypertension. It is usually managed with glucocorticoids, and antihypertensives are added if blood pressure remains uncontrolled. In this case, glucocorticoid therapy was not tolerated and treatment with aldosterone antagonist monotherapy was effective in controlling his hypertension.