bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐inflammatory, Antioxidant, and Antibacterial Activities with Molecular Docking Studies of Vitex Trifolia L. Targeting Human COX‐2 and Peroxiredoxin‐5
Authors: Fawwaz Muammar , Purwono Bambang , Sidiq Yasir , Arwansyah  , Arsul Muhammad Ikhlas , Fitriana  , Pratama Mamat , Fajriani Aliah , Kusuma Andi Trihadi , Amirullah  , Musdalifah Andi Alifia , Sarfandi Agus , Baits Muzakkir 
Published: October 2024

AbstractVitex trifolia L. is widely used as a traditional medicine owing to its secondary metabolites. This study aimed to determine the phytochemical profiling of the ethanolic extract of V. trifolia leaves (EEVL). Additionally, biological activities were investigated, supported by molecular docking studies. The total flavonoid and phenolic contents of the EEVL were 35.25 ± 0.13 mg QE/g extract and 39.55 ± 1.43 mg GAE/g extract, respectively. The EEVL exhibits anti‐inflammatory activity with a half‐maximal inhibitory concentration (IC50) value of 153.59 µg/mL. The antioxidant activity of the EEVL exhibited an IC50 value of 20.41 ± 0.08 µg/mL with the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging method, a half‐maximal effective concentration value of 80.85 ± 0.39 µg/mL with the cupric‐reducing antioxidant capacity (CUPRAC) method, and a capacity of 180.58 mg QE/g extract with the ferric‐reducing antioxidant power (FRAP) method. At 16% concentration, the EEVL exhibited an antibacterial activity against some pathogenic bacteria. Molecular docking studies reported that casticin interacts with sodium diclofenac similarly toward 1PXX. However, artemitin exhibited better affinity toward 1HD2 than ascorbic acid. Thus, the EEVL has significant potential as a natural source for treating various diseases related to inflammation, oxidation, and infection. Moreover, screening of its active compounds is necessary for further exploration.
Iron‐Catalyzed, Visible‐Light‐Mediated Decarboxylative Cyclization Reactions: A Viable Approach to 2,3‐Dihydrobenzofuran Derivatives
Authors: Shi Zhaocheng , Li Huimin , Sheng Wenli , Chen Junmin 
Published: October 2024

AbstractThis study reports a visible‐light‐induced photoredox decarboxylative cyclization reaction of enone acids via iron photocatalysis. The protocol provides a facile entry to structurally valuable highly functionalized 2,3‐dihydrobenzofuran scaffolds in good to excellent yields. This method features cheap iron photocatalyst, excellent functional group tolerance, wide substrate scope, and environmentally friendly features.
Crystal Form‐Dependent MnS for Diabetic Wound Healing: Performance and Mechanistic Insights
Authors: Duan Xiaomeng , Xu Kaikai , Zhang Mingzhu , Xia Yuanyuan , Wang Liping , Chen Bingbing , Wang Chongchong , Wei Shaohua , Zhou Lin 
Published: October 2024

AbstractIn pharmaceuticals, the structural and functional alterations induced by biotransformation are well‐documented. Many pharmaceuticals exist in various crystal forms, which govern their transformation and significantly impact their activity. However, in the field of inorganic nanomedicine, there is a paucity of research focusing on the influence of crystal form‐dependent “metabolism” (transformation) on their activity and biomechanism. This study delves into the distinct performances of two crystal forms of manganese sulfide (MnS), namely α‐MnS and γ‐MnS, in bacteria‐infected diabetic wound healing. In the initial stage of a wound, where the environment is neutral to slightly alkaline, MnS partially converts to MnxOy (comprising Mn2O3 and Mn3O4) and concurrently produces hydrogen sulfide (H2S); the conversion efficiency of γ‐MnS significantly surpasses that of α‐MnS. Additionally, γ‐MnS is more soluble than α‐MnS, which allows it to generate more Mn2+. These components collectively contribute to the superior bacteriostatic properties of MnS. In wound related cells, MnS stimulates the production of collagen I and vascular endothelial growth factor (VEGF), promote the M1 macrophages polarizing to the M2 phenotype, for extracellular matrix (ECM) remodeling. Notably, different transformation products have distinct functions. Consequently, the activity of MnS is dependent on its original crystal form related solubility and transformation efficiency.
“All‐in‐One” MnO2@PtAuRu Nanoreactor for Self‐Replenishing and Cascade Catalytic Therapy of Cancer
Authors: Li Qing , Wu Shenshen , Li Bin , Zhou Pengyou , Wang Hemin , Zhang Xianan , Meng Qingtao , Li Xiaobo , Chen Hanqing , Pang Yuanfeng , Chen Rui 
Published: October 2024

AbstractLimited by the insufficient catalytic substrates such as H2O2 and O2 in the tumor microenvironment (TME), the continual propelling of nanozymes catalysis therapy of cancer remains a challenge. Here, an all‐in‐one MnO2@PtAuRu nanoreactor is constructed for self‐propelled and cascade catalytic therapy of tumors. The MnO2@PtAuRu is constructed by using hollow MnO2 (≈150 nm) as the core‐carrier and ultrasmall PtAuRu nanoclusters (≈2 nm) anchoring on the surface MnO2. According to the glucose oxidase (GOD)/catalase (CAT)/peroxidase (POD) mimic multienzyme activity of PtAuRu nanoclusters, cascaded nanocatalytic reactions can be self‐replenishing to persistently produce •OH for superior chemodynamic therapy (CDT). Additionally, the MnO2 carrier can protect the ultrasmall PtAuRu nanoclusters during the circulation and the overexpressed glutathione (GSH) in the tumor can also be degraded by the MnO2 to synergy the CDT. The MnO2@PtAuRu displays obvious photothermal properties which further enhance the cascade catalytic ability and synergistic therapeutic effect. Therefore, this all‐in‐one nanozyme provides a promising strategy for the rational design of self‐replenishment and self‐replenishing cascade catalytic therapy of cancer.
Probing Surface‐Mediated Electronic Coupling in Flat Hexagonal Phosphorus Nanostructures and Monolayer on Au(111)
Authors: Karn Abhishek , Michel Ian‐Evan , Lezoualc'h Mahé , Chacon Cyril , Girard Yann , Smogunov Alexander , Dappe Yannick J. , Lagoute J. 
Published: October 2024

AbstractDue to its diverse allotropes and intriguing properties, 2D phosphorus, also known as phosphorene, is a material of great interest. Here, the successful growth of flat hexagonal 2D phosphorus on Au(111) is reported. Starting from phosphorus linear chains at low coverage, a porous network and finally an extended 2D flat hexagonal (HexP) layer while increasing phosphorus deposition is formed. Using scanning tunneling microscopy/spectroscopy combined with ab initio calculations, the structure and electronic properties of the as‐grown phosphorus structures are followed. The progressive formation of a phosphorus electronic band in the conduction band region is followed. More strikingly, a partial flatband that appears only on the HexP phase characterized by a sharp peak in the electronic spectrum is observed. These bands arise from the hybridization of phosphorus and gold atoms. This novel phosphorus‐based structure exhibits remarkable electronic properties due to gold mediated phosphorus–phosphorus electronic coupling. This work paves the way for new interface material developments with attractive electronic properties.
Electric Field‐Induced Ordered‐Structural Aerogels Enable Superinsulation and Multifunctionality
Authors: Li Wenjie , He Fei , Liu Hang , Jiang Yuncong , Mu Yuwen , Wang Chen , Zhou Xin , Jiang Siyi , Xu Lingfeng , Wang Linyan , He Xiaodong , Li Mingwei 
Published: October 2024

Abstract1D flexible fibers assembled 3D porous networked ceramic fiber aerogels (CFAs) are developed to overcome the brittleness of traditional ceramic particle aerogels. However, existing CFAs with disordered and quasi‐ordered structures fail to balance the relationship between flexibility, robustness, and thermal insulation. Creating novel architectural CFAs with an excellent combination of performances has proven extremely challenging. In this paper, a novel strategy is adopted to fabricate porous mullite fibrous aerogels (MFAs) with ordered structures by combining fiber sedimentation and electric field‐induced fiber alignment techniques. For the first time, electric field‐induced alignment of ceramic fibers is utilized to prepare bulk aerogels on a large scale. The resulting MFAs exhibit ultra‐low high‐temperature thermal conductivity of 0.0830 W m−1 K−1 at 1000 °C, anisotropic mechanical and sound absorption performances, and multifunctionality in terms of the combination of thermal insulation, sound absorption, and hydrophobicity. The successful synthesis of such fascinating materials may provide new insights into the design and development of multifunctional CFAs for various applications.
Constructing Bionic Perovskite Smart Photovoltaic Windows with Switchable Colors and High Cycling Stability
Authors: Xin Yi , Zou Shengwen , Jin Jinlong , Liu Guangxin , Yan Xiaojun , Huang Jianmei 
Published: October 2024

AbstractSmart photovoltaic windows (SPWs) provide a high‐efficiency and energy‐saving strategy owing to the dual capabilities of electricity generation and sunlight modulation achieved by tunable colors and transmittances. Due to the deterioration of chromic process on photovoltaic layers, SPWs usually suffer from poor cycling stability. Moreover, thermochromic SPWs with a multilayer structure usually change transmittance without reversible color transitions. To address these issues, inspired by chameleon skin, bionic SPWs are designed and constructed by integrating hydrogel, CsPbBr3 semitransparent perovskite solar cells (ST‐PSCs), and transparent polymer film. The SPWs realize reversible transitions between transparent green (25 °C) and opaque yellow (45 °C) states in a short duration (2 min) under natural conditions. By optimizing perovskite film and ultrathin‐metal electrodes, CsPbBr3 ST‐PSCs achieve a good trade‐off between transmittance and efficiency, delivering the highest photovoltaic efficiency (8.35%) and a record light utilization efficiency (4.43). Ultimately, the multilayer SPWs maintain stable optical properties and more than 88% initial conversion efficiency after 100 transition cycles, presenting excellent cycling stability. This study proposes a novel approach and device structure for SPWs with high cycling stability, switchable colors, and switchable transmittances. It also paves the way for smart photovoltaic deployment in buildings and many other fields.
Building Cobalt‐Nickel Diatomic Sites as Oxygenophilic ORR Catalyst with Strong Cl−‐Corrosion Resistance for Seawater Batteries
Authors: Lu Junda , Hong Chao , Li Guoyang , Zheng Xuerong , Yin Zexiang , Zhang Jinfeng , Dong Yan , Wang Haozhi , Wang Yang , Deng Yida 
Published: October 2024

AbstractThe seawater battery (SWB) holds great potential as the next‐generation energy supply system for marine electrical equipment. However, its efficiency and durability are hindered by low oxygen concentration and harmful Cl− adsorption and corrosion in seawater. Herein, a host‐guest strategy is developed to fabricate diatomic catalysts with adjacent Co and Ni sites on nitrogen‐doped carbon (CoNi‐DAC), where Co and Ni atoms are each coordinated to three nitrogen atoms. Theoretical calculations and in situ characterization reveal that the synchronized reduction of Co and Ni valence states enhances ORR kinetics by optimizing the O2 adsorption energy barrier, facilitating direct O─O bond cleavage and preventing *OOH intermediate formation. This electronic modulation enhances oxygenophilicity and Cl− corrosion resistance. The Co/Ni diatomic sites synergistically improve ORR catalytic activity, achieving a half‐wave potential (E1/2) of 0.79 V and exceptional long‐term durability of nearly 700 h in natural seawater. The assembled SWB with CoNi‐DAC coated carbon brush electrode attains a peak power density of 3.3 W L−1. This work offers valuable insights into the design and development of advanced ORR electrocatalysts for natural seawater environments.
Analysis of Software Developers' Programming Language Preferences and Community Behavior From Big5 Personality Traits
Authors: Mukta Md. Saddam Hossain , Antu Badrun Nessa , Azad Nasreen , Abedeen Iftekharul , Islam Najmul 
Published: October 2024

ABSTRACTMany programming languages and technologies have appeared for the purpose of software development. When choosing a programming language, the developers' cognitive attributes, such as the Big5 personality traits (BPT), may play a role. The developers' personality traits can be reflected in their social media content (e.g., tweets, statuses, Q&A, reputation). In this article, we predict the developers' programming language preferences (i.e., the pattern of picking up a language) from their BPT derived from their content produced on social media. We randomly collected data from a total of 820 Twitter (currently X) and Stack Overflow (SO) users. Then, we collected user features (i.e., BPT, word embedding of tweets) from Twitter and programming preferences (i.e., programming tags, reputation, question, answer) from SO. We applied various machine learning (ML) and deep learning (DL) techniques to predict their programming language preferences from their BPT. We also investigated other interesting insights, such as how reputation and question‐asking/replying are associated with the users' BPT. The findings suggest that developers with high openness, conscientiousness,
and extraversion are inclined to mobile applications, object‐oriented programming, and web programming, respectively. Furthermore, developers with high openness and conscientiousness
traits have a high reputation in the SO community. Our ML and DL techniques classify the developers' programming language preferences using their BPT with an average accuracy of 78%.
Genome‐wide association studies in a diverse strawberry collection unveil loci controlling agronomic and fruit quality traits
Authors: Muñoz Pilar , Roldán‐Guerra Francisco Javier , Verma Sujeet , Ruiz‐Velázquez Mario , Torreblanca Rocío , Oiza Nicolás , Castillejo Cristina , Sánchez‐Sevilla José F. , Amaya Iraida 
Published: October 2024

AbstractStrawberries (Fragaria sp.) are cherished for their organoleptic properties and nutritional value. However, breeding new cultivars involves the simultaneous selection of many agronomic and fruit quality traits, including fruit firmness and extended postharvest life. The strawberry germplasm collection here studied exhibited extensive phenotypic variation in 26 agronomic and fruit quality traits across three consecutive seasons. Phenotypic correlations and principal component analysis revealed relationships among traits and accessions, emphasizing the impact of plant breeding on fruit weight and firmness to the detriment of sugar or vitamin C content. Genetic diversity analysis on 124 accessions using 44,408 markers denoted a population structure divided into six subpopulations still retaining considerable diversity. Genome‐wide association studies for the 26 traits unveiled 121 significant marker‐trait associations distributed across 95 quantitative trait loci (QTLs). Multiple associations were detected for fruit firmness, a key breeding target, including a prominent locus on chromosome 6A. The candidate gene FaPG1, controlling fruit softening and postharvest shelf life, was identified within this QTL region. Differential expression of FaPG1 confirmed its role as the primary contributor to natural variation in fruit firmness. A kompetitive allele‐specific PCR assay based on the single nucleotide polymorphism (SNP) AX‐184242253, associated with the 6A QTL, predicts a substantial increase in fruit firmness, validating its utility for marker‐assisted selection. In essence, this comprehensive study provides insights into the phenotypic and genetic landscape of the strawberry collection and lays a robust foundation for propelling the development of superior strawberry cultivars through precision breeding.
Teacher Use of Generative AI for Read‐Aloud Question Prompts
Authors: Yang Shuling , Trainin Guy , Appleget Carin 
Published: October 2024

AbstractThe advent of Generative AI technologies, such as ChatGPT, in November 2022, necessitated immediate and critical attention from the educational research community. The impact of GenAI in education, though not yet clear, has the potential to be transformative. More specifically, the focus of this paper is on how to integrate GenAI into elementary literacy education. We, as teacher educators, aim to showcase how to prompt ChatGPT to generate high‐quality questions during a read‐aloud. We discuss the easy access teachers have to GenAI tools and stress the pivotal role they have in decision‐making. We encourage teachers to explore, learn, and understand how to work with GenAI tools to get the most out of it and thus facilitate their agency, teaching, and learning.
Antiviral Activity of Plant‐Based Additives Against African Swine Fever Virus (ASFV) in Feed Ingredients
Authors: Lai Thi Ngoc Ha , Trinh Thi Bich Ngoc , Than Thi Tam , Mai Nguyen Tuan Anh , Biuki Niku Moussavi , Eckel Bernhard , Eckel Viktor P. L. , Nguyen Thi Lan , Le Van Phan 
Published: October 2024

ABSTRACTBackgroundAfrican swine fever (ASF) is one of the deadliest swine diseases with haemorrhagic symptoms and a high mortality rate. Plant‐derived additives are potential antiviral agents against viruses due to their environmental and user‐friendly properties.ObjectivesThis study aims to evaluate the efficacy of plant‐based additives (Phyto.A04 and Phyto.B) compared to an organic acid blend (OAB) in inactivating ASF virus (ASFV) in cell culture and feed.MethodsASFV‐spiked feed was treated with individual or combined additives such as OAB, Phyto.A04 and Phyto.B. The viability of ASFV after treatment of ASFV‐spiked feed with additives was then confirmed by both methods, real‐time PCR and cell culture.ResultsThe results of the in vitro test with cell cultures showed that all three additives (OAB, Phyto.A04 and Phyto.B) exerted a strong virucidal effect on ASFV in porcine alveolar macrophage cells. OAB at a concentration of 0.3% reduced the virus concentration from 4.48 log10 HAD50/mL after 1 day of treatment (day 1) to 3.29 log10 HAD50/mL after 3 days of treatment (day 3) and remained undetected after 7 days of treatment (day 7). In Phyto.A04 with 1%, the virus was only detectable on day 1 (3.53 log10 HAD50/mL). Phyto.B with 0.01% and 0.05% both showed good efficacy in completely inhibiting virus presence on days 3 and 7.ConclusionsAll additives, OAB, Phyto.A04 and Phyto.B, were able to inactivate ASFV in a dose‐dependent manner, as confirmed by cell culture and PCR methods. The combination of additives at different concentrations consistently improved the virucidal results.
The role of indigenous healers in treating surgical conditions in the rural Eastern Cape of South Africa
Authors: Sangana Neha , Rodi Paolo , Tshabalala Ntombekhaya , Bell Ethan , Mhlatyelwa Patheka , Miller Andrew , Mji Gubela , Chu Kathryn 
Published: October 2024

AbstractBackgroundIndigenous knowledge healers (IKHs) provide alternative healthcare to formal health services in rural South Africa, but there is a gap in knowledge regarding their treatment of surgical conditions. This study evaluated IKH surgical care and described their perspective of the dual health system.MethodsA cross sectional survey of IKHs in the Madwaleni Hospital catchment of the Eastern Cape, South Africa was conducted. Topics included the training and experience of IKHs, treatment of nine common surgical conditions, referral patterns, disease origin beliefs, benefits and limitations of care, and collaborative opportunities between the two health systems.ResultsThirty‐five IKHs completed the survey. IKHs were consulted by persons with all nine surgical conditions. The most common forms of treatment were application of an ointment on the affected site (88%) and oral medication (82%). Operative treatment was only done for abscess. Referrals to the formal healthcare sector were made for all surgical conditions. IKHs reported that they were limited by their lack of training and resources to perform operations. On the other hand, they perceived the treatment of the spiritual aspect of surgical disease as a benefit of their care. Thirty‐five (100%) IKHs were interested in closer collaboration with the formal health sector.ConclusionIKHs treat surgical conditions but refer to the formal health sector when diagnostic and operative services are needed. More research is needed to determine the potential advantages and disadvantages between the formal health sector and IKH collaboration.
Tracing Different Types of Local Economic Benefits of RIs: The Case Study of LHC
Authors: Alix Leslie , Gutleber Johannes 
Published: October 2024

AbstractCERN is operating the world’s largest particle accelerator complex in the world. The interconnection of versatile particle accelerators working with different particle beams at different intensities and energies continue to attract scientists and engineers from all over the world. The socio-economic effects generated by the presence of in the region are manifold. They include, but are not limited to consumer spending, real-estate investments and local business and services activities, investments in education, leisure activities and tourism, urban development and tax contributions. This chapter traces different local socio-economic effects of concentrating a large number of people around a research infrastructure.
Thinking How to Define and Measure Impacts of RIs
Authors: Catalano Gelsomina 
Published: October 2024

AbstractThe potential of research infrastructures (RIs) to generate impacts beyond science is widely recognised by policy makers and funding agencies. Hence, the growing demand to be able to measure RIs impacts not only for research but for the society at large. The main challenges associated to this request deal with (i) the definition of RI’s impact, (ii) the identification of the variety of impacts which can be generated by RIs of different disciplines and of different types, (iii) measuring these impacts and (iv) exploring the way they are generated. This paper addresses these challenges by suggesting a possible roadmap to guide the conceptualisation and the measurement of impacts of a research infrastructure. Specifically, drawing from recent discussion on socio-economic impact assessments of RIs as well as practices of measurement of RI’s impacts, it highlights the variation of impacts which can be encountered across research infrastructures of different types and disciplines and points out to the challenges faced in measuring the different RI’s impacts.
Plenoptic Sensing Systems
Authors: Fang Lu 
Published: October 2024

AbstractPlenoptic sensing systems are a type of camera that can capture the multidimensional information of the light field, e.g., capture both the light rays’ intensities and directions. This allows for reconstructing the high-dimensional light fields and supporting various post-capture features such as depth perception, refocusing, synthetic aperture, etc. As the widely used CMOS-based image sensor can only record the intensity of light rays, conventional camera cannot directly capture the multidimensional light field. To address this challenge, a variety of plenoptic sensing systems with specialized hardware and algorithms have been proposed.
High-Resolution Plenoptic Sensing
Authors: Fang Lu 
Published: October 2024

AbstractThe high-resolution plenoptic sensing system can capture light field with a high level of detail and clarity. Resolution refers to the amount of detail that can be discerned in the reconstructed image or light field. The cutting edge of high-resolution plenoptic sensing is gigapixel plenoptic sensing, specifically refers to a system capable of capturing images with billions of pixels, resulting in extremely high-resolution light field.