bluuebunny/crossref_metadata_2025_split huggingface dataset:
12461 The Impact Of Switching From A Glp-1 Analog To Tirzepatide On Blood Glucose Levels, Body Weight, And Liver Function In Patients With Type 2 Diabetes
Authors: Mizoguchi R , Sawamura T , Ohmori A , Yagishita N , Kometani M , Yoneda T , Karashima S 
Published: October 2024

Abstract
Disclosure: R. Mizoguchi: None. T. Sawamura: None. A. Ohmori: None. N. Yagishita: None. M. Kometani: None. T. Yoneda: None. S. Karashima: None.
Context: Tirzepatide belongs to a new class of anti-diabetic agents that stimulate both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors, which have strong blood glucose-lowering and large body weight reduction effect. Because of these characteristics of tirzepatide, it is expected to have beneficial effects for obese patients who need further blood glucose control. In the pharmacological approaches to glycemic treatment described by the American Diabetes Association, GLP-1 analogs are positioned as strong blood glucose-lowering agents that additionally reduce body weight (BW). Furthermore, GLP-1 analogs also improves liver injury in patients with fatty liver and diabetes. Tirzepatide reportedly has a greater blood glucose-lowering effect and body weight reduction than dulaglutide and semaglutide, which are common GLP-1 analogs in Japan. However, no data about the switching from these GLP-1 analogs to tirzepatide are available. In addition, The effect of tirzepatide on steatohepatitis is still unknown. Therefore, this study evaluated the effects of switching from dulaglutide to tirzepatide on blood glucose level, BW, and liver function. Material and Methods: Data from 40 patients with type 2 diabetes who received a prescription change from dulaglutide to tirzepatide were retrospectively analyzed at the 3 and 6 months after the switch. The analyzed data included glycosylated hemoglobin (HbA1c), BW, body mass index (BMI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase levels (γ-GTP) levels, and fibrosis-4 index. In addition, factors influencing the changes in HbA1c, BW, ALT, and fibrosis-4 index at 6 months were evaluated. Results: The mean HbA1c levels decreased from 7.9 ± 1.1% at baseline to 7.0 ± 0.8% at 3 months (p &lt; 0.001) and 6.7 ± 0.7% at 6 months (p &lt; 0.001). The mean BW decreased from 74.9 ± 18.3 kg at baseline to 71.9 ± 17.9 kg at 3 months (p &lt; 0.001) and 71.3 ± 18.0 kg at 6 months (p &lt; 0.001). The change in HbA1c level was negatively correlated with baseline HbA1c level. However, the BW reduction was observed regardless of baseline characteristics. AST, ALT, and γ-GTP levels were also significantly lower 6 months after the switch. The decrease in ALT level was greater in patients with higher baseline AST, ALT, and γ-GTP levels. The fibrosis-4 index did not improve during the study period, but there was a decreasing trend in patients with higher baseline fibrosis-4 index. Conclusion: Switching from dulaglutide to tirzepatide may have beneficial effects on blood glucose levels, BW, and liver function in patients with type 2 diabetes.
Presentation: 6/2/2024
6399 Unmasking A Silent Threat
Authors: St. Jean Karen M , Upadhyay Jagriti , Aron Polina , Tchong Leo , Toraldo Gianluca 
Published: October 2024

Abstract
Disclosure: K.M. St. Jean: None. J. Upadhyay: None. P. Aron: None. L. Tchong: None. G. Toraldo: None.
Introduction: Checkpoint inhibitor-associated autoimmune diabetes mellitus (CIADM) is a rare illness, with an incidence of 0.2-1.4%. However, its clinical implications are significant due to the high incidence of DKA at presentation, the lifelong persistent insulin deficiency, and the associated risk factors of diabetes complications and decreased life expectancy. This substantially impacts the patient's quality of life, healthcare costs, and treatment adherence. Case Description: A 63-year-old man with a history of type 2 DM well controlled with GLP-1A once a week presented to the hospital for persistent hyperglycemia in the 400s associated with nausea and vomiting. Upon admission, the patient had DKA with a pH of 7.3, bicarbonate 9 mmol/L, AG 29 mmol/L, elevated beta-hydroxybutyrate 10.42 mmol/L, and glucose of 655 mg/dL. The patient had a significant past medical history of stage IIA lung adenocarcinoma in 2019, s/p surgery and adjuvant chemoradiotherapy and was on surveillance till he got metastatic recurrence in 2023. Four weeks before his admission, patient was started on immunotherapy with pembrolizumab for recurrent disease.A complete workup in the hospital showed a positive GAD-65 and a low C-peptide 0.10 ng/dL consistent with diagnosis of insulin deficiency likely causing DKA. The patient was started on insulin, and blood sugars are now well controlled on insulin regimen. Discussion: Our case had a unique presentation, given the acute onset within four weeks of starting immunotherapy and the severity of his presentations by developing DKA. The median onset described in the literature for insulin deficiency from immunotherapy is typically between 12-25 weeks in different reports. DKA is a life-threatening illness with a 2-5% mortality rate in the United States. Hence, early identification of at-risk patients is vital to prevent hospitalizations and mortality.Limited data is available about CIADM, and the presence of autoantibodies appears to be associated with a more rapid and severe onset of CIADM. This highlights the need for identifying biomarkers or predictive factors to help identify patients at higher risk and potentially intervene earlier in their treatment.Finally, CIADM is characterized by sudden permanent b-cell failure occurring after immuno-therapy. Therefore, it is essential to be familiarized with CIADM and its unique characteristics to provide timely and appropriate care to affected individuals. Moreover, as immunotherapy becomes increasingly common in cancer treatment, awareness of CIADM becomes even more critical for managing potential complications and optimizing patient outcomes.
Presentation: 6/2/2024
8615 Unveiling The Muscle-Specific Role Of Fat-Specific Protein 27 In Regulating Muscle Performance And Whole-Body Glucose Homeostasis
Authors: Basri R , Balakrishnan B , Slayton M , Becker C , Hussein H , Puri I , Gupta A , Sharma V , Baumann C , Consitt L , Puri V 
Published: October 2024

Abstract
Disclosure: R. Basri: None. B. Balakrishnan: None. M. Slayton: None. C. Becker: None. H. Hussein: None. I. Puri: None. A. Gupta: None. V. Sharma: None. C. Baumann: None. L. Consitt: None. V. Puri: None.
Skeletal muscle (SkM) function, strength, and intrinsic muscle quality are closely linked to the pathogenesis and pathophysiology of metabolic disease. However, the regulatory molecular mechanisms in SkM performance remain elusive. Our study identifies Fat-Specific Protein (FSP27) as a novel player in muscle function. FSP27, previously found to be expressed in adipose and liver, is highly expressed in skeletal muscles (SkM). We recently found that the global FSP27 knockout (Fsp27-/-) mice have severely reduced muscle performance. Also, our human data identified a positive correlation of SkM FSP27 expression with indices of muscle performance such as aerobic capacity, muscle strength, and responsivity to exercise training. However, these studies could not explain the role of muscle-specific FSP27 Therefore, to study the physiological and mechanistic role of SkM-specific FSP27, we generated a loss-of-function Fsp27 knockout mouse model through muscle-specific ablation of FSP27 (M-Fsp27-/-). Treadmill running and hanging-grid tests were performed to study exercise endurance and muscle strength, respectively. M-Fsp27-/- showed significantly reduced running endurance and reduced muscle strength. In addition, glucose and insulin tolerance were significantly reduced in M-Fsp27-/- mice, suggesting the effect of muscle-specific FSP27 in whole-body glucose homeostasis. No sexual dimorphism was observed in muscle-specific functions of FSP27 and its effect on whole-body glucose homeostasis, with females showing similar results to males. Moreover, M-Fsp27-/- mice showed reduced energy expenditure compared to their littermate floxed controls. Interestingly, we found that FSP27 interacts with lactate dehydrogenase A (LDHA), and the rate of lactate production was found to be negatively associated with FSP27 expression in the SkM, indicating the molecular role of FSP27 in substrate utilization. Overall, our results identify a novel role of FSP27 in regulating muscle performance and metabolism via its effect on substrate utilization to produce energy.
Presentation: 6/1/2024
5069 Utilizing The Electronic Health Record To Improve Transitions Of Care From Pediatric To Adult Endocrinology For Patients With Type 1 Diabetes
Authors: McHan Lara Crawford , Tich Jennifer Nicole , Augustine Marilyn 
Published: October 2024

Abstract
Disclosure: L.C. McHan: None. J.N. Tich: None. M. Augustine: None.
During late adolescence and emerging adulthood, patients are becoming more independent and assuming more responsibility for their care. The transition from pediatric to adult healthcare providers is a particularly vulnerable time for patients with diabetes since disruptions in care can lead to poor health outcomes such as poor glycemic control, increased healthcare utilization, and increased occurrence of complications related to diabetes. In a preliminary chart review, 36% of pediatric patients at our institution with type 1 diabetes (T1DM) referred to adult endocrinology in the year 2022 have not yet established care with an adult endocrinologist. Of these patients, 67% had a first appointment scheduled with adult endocrinology. For patients who have established care with adult endocrinology, the average time between their last pediatric visit and first adult visit was 10 months. To address these gaps in care during the transition process, we created a multidisciplinary team, including representatives from pediatric and adult endocrinology with the goal of utilizing the electronic health record (EHR) to improve transitions of care for adolescents and young adults with T1DM at our institution. Our team consists of physicians, advanced practice providers (APPs), a social worker, and representatives from our information systems division. Because buy-in from providers is a cornerstone of successful transition planning, we surveyed the pediatric endocrinology providers to assess attitudes regarding transitions of care and received 4 physician and 4 APP responses. Fifty percent of providers felt it was extremely important to discuss transition to adult care with their patients, and all providers reported feeling comfortable discussing transition. The age at which providers initiate discussion about transition with their patients varies significantly; half of providers reported waiting until patients are 18 years or older, and only one provider starts discussing transition at the recommended age of 12-13 years old. One provider reported discussing transition with their patients at every visit, while 25% discuss transition every 6 months and 50% discuss transition yearly. When asked what tools would help providers address transition to adult care with patients, 100% selected a reminder in the diabetes note template. We are actively working to incorporate reminders to discuss transition into the diabetes note template. Additionally, we have partnered with the Endocrine Society to incorporate a T1DM skills checklist into the EHR. While the long-term health benefits of discussing transition to adult care may not be evident for years, our hope is that these tools encourage providers to engage in earlier and more frequent discussions about independent disease management and transition to adult care.
Presentation: 6/2/2024
Inherited anoxia tolerance and growth performance can result in enhanced invasiveness in hybrid fish
Authors: Dabrowski Konrad , Panicz Remigiusz , Fisher Kevin J. , Gomelsky Boris , Eljasik Piotr 
Published: October 2024

ABSTRACT
Northern hemisphere freshwater ecosystems are projected to experience significant warming and shortening of winter duration in this century. This change coupled with depletion of oxygen (hypoxia) will result in a shift toward fish species with higher optimal temperatures for growth and reproduction that can mitigate hypoxic stress. Here, we tested the assumption that reproduction between two distant species, i.e. anoxic-intolerant common carp (Cyprinus carpio) and anoxic-tolerant goldfish (Carassius auratus), results in the expression of genes responsible for ethanol synthesis (alcohol dehydrogenase and pyruvate dehydrogenase subunit E1β2). The expression of this ethanol-producing pyruvate decarboxylase pathway may transform the biochemical characteristics of progeny into anoxic-tolerant hybrids, expanding their suitable environmental range and potentially increasing invasiveness. Concurrently, a genetic strategy for improving fish tolerance to oxygen-depleted environments will be a valuable physiological trait in fish culture. Differential quantification of gene expression by analyzing mRNA revealed that, compared with koi×koi, koi female×goldfish male (F1 hybrid) possessed the pyruvate dehydrogenase subunit E1β2 gene construct, which was expressed at significantly greater levels in red muscle. The potential of this hybrid to both survive in extreme anoxic conditions and grow at elevated water temperatures would likely contribute to their ecological success.
Job satisfaction of multidisciplinary staff working in intensive care units: a cross-sectional study in Qatar
Authors: Jacob Prasobh , Surendran Praveen Jayaprabha , Gupta Poonam , El Hassan Mawahib Ali Mohammed 
Published: October 2024

Background/Aims Job satisfaction is an important contributor to the efficacy and success of organisations. An intensive care unit is a highly skilled area of healthcare that can be a physically and mentally challenging environment for staff, potentially impacting job satisfaction. This study aimed to assess job satisfaction levels among multidisciplinary staff members working in the intensive care units of a hospital in Qatar and evaluate how this is affected by sociodemographic and employment factors. Methods This was a cross-sectional, quantitative study that used a survey method. A total of 142 intensive care unit nurses, physicians and allied health professionals were recruited via random sampling from a tertiary hospital in Qatar. The Minnesota Satisfaction Questionnaire (short form) was used to collect data on respondents' intrinsic, extrinsic and overall job satisfaction levels, using statements scored with 5-point Likert scales. The survey also collected data on respondents' gender, age, job category and years of experience working in intensive care. Data were analysed using Shapiro-Wilk tests, Mann-Whitney U tests, Kruskal–Wallis tests and analysis of variance. Mean overall job satisfaction scores were classified as low (<3.00), moderate (3.00–3.99) or high (>4.00). A P value of <0.05 indicated statistical significance. Results The mean overall job satisfaction score was 3.82 out of 5.00, indicating moderate satisfaction. There were strong correlations between job satisfaction and both intrinsic (0.940) and extrinsic (0.894) satisfaction. There was a significant difference in job satisfaction levels depending on respondents' years of experience working in intensive care units (P=0.0477), with those who had less than 10 years of experience having the highest job satisfaction levels and those with 20–24 years' experience having the lowest job satisfaction levels. There were no significant differences between the job satisfaction levels of participants in different gender, age and job categories. Conclusions This study suggests that intensive care unit staff with more years of experience may have lower job satisfaction than those with fewer years of experience. Healthcare organisations should consider implementing targeted interventions to enhance job satisfaction, such as opportunities for professional development, recognition programmes, mentorship programmes, stress management workshops and efforts to improve work-life balance.
Multi-screw extruders – an overview
Authors: Formela Krzysztof , Rodak Agata , Bartnicki Adrian , Eyigöz Barış 
Published: October 2024

Screw extrusion is a cost-effective and solvent-free method for manufacturing polymer blends and composites. This article reviews the latest developments in the field of multi-screw extruders, i.e. triple-screw, quad-screw, octa-screw, ring, planetary and multi-rotation system (MRS). The authors also discussed limitations and directions of multi-screw extruders development.
Reduced cardiovascular and metabolic responses during eccentric stepping exercise: A pilot study
Authors: Renwick Nicholas C. , Egginton Stuart , Ferguson Carrie 
Published: October 2024

AbstractThis study compared cardiovascular and metabolic responses during concentric and eccentric stepping. Eight participants (5 m, 3f; 22 ± 2 years) performed maximal concentric and eccentric ramp incremental tests on a modified stepping ergometer. Subsequently, three randomized 15‐min constant‐power tests were performed (1) concentric stepping at 90% of the concentric lactate threshold (LT), (2) eccentric stepping at the same power, and (3) eccentric stepping at the same oxygen uptake (V̇O2). At equivalent power (36 ± 6 W, p = 0.62), eccentric stepping resulted in 46 ± 8% lower V̇O2, 16 ± 6% lower heart rate (HR), and 11 ± 5% lower mean arterial blood pressure compared to concentric (p < 0.01). Matching V̇O2 required 65 ± 19% more power during eccentric stepping (p < 0.01). During this test, eccentric V̇O2 and HR continued to increase, resulting in a 22 ± 29% higher V̇O2 and 19 ± 16% higher HR in the final minute (p < 0.001). Reduced cardiorespiratory demand during eccentric stepping at the same power as concentric demonstrates a higher eccentric power is required to produce the same V̇O2. However, despite being below the concentric LT, eccentric V̇O2 and HR continued to increase past the predicted steady state, indicating a higher exercise intensity.
Monitoring adult Delia platura (Diptera: Anthomyiidae) in New York State corn fields using blue and yellow sticky cards
Authors: Olaya-Arenas Paola , Crowther Shea , Degni Janice , DiPaola Anna , Elliott-Vidaurri Lilly V. , Gabriel Aaron , Leeser Jacob , Luttermoser Tim , MacKenzie Laura , Miller Jeff , Myers Holly , O’Neil Kitty , Peng Angela , Rooney Olivia , Rusinek Teresa , Schroeder Hayley , Smith Erik A. , Stanyard Mike , Wise Ken , Zuefle Marion , Poveda Katja 
Published: October 2024

Abstract
The seedcorn maggot, Delia platura (Meigen; Diptera: Anthomyiidae), is a polyphagous pest that feeds on decaying organic matter, seeds, and seedlings of several crops, including corn (Zea mays L.; Poaceae). In corn and soybeans, D. platura is a sporadic pest. To make recommendations as to which sticky trap color is more effective at trapping D. platura, we sampled 52 corn fields in four regions across New York State with blue and yellow sticky cards. More adults were caught with blue (77.6 %) than yellow cards (22.4 %). The same pattern was observed when all individuals were combined and separated by females and males. The higher captures with blue sticky cards were consistent across space and time, indicating the effectiveness of trapping adults and monitoring them at a regional scale.
Transformative insights: Image-based breast cancer detection and severity assessment through advanced AI techniques
Authors: Patra Ankita , Biswas Preesat , Behera Santi Kumari , Barpanda Nalini Kanta , Sethy Prabira Kumar , Nanthaamornphong Aziz 
Published: October 2024

Abstract
In the realm of image-based breast cancer detection and severity assessment, this study delves into the revolutionary potential of sophisticated artificial intelligence (AI) techniques. By investigating image processing, machine learning (ML), and deep learning (DL), the research illuminates their combined impact on transforming breast cancer diagnosis. This integration offers insights into early identification and precise characterization of cancers. With a foundation in 125 research articles, this article presents a comprehensive overview of the current state of image-based breast cancer detection. Synthesizing the transformative role of AI, including image processing, ML, and DL, the review explores how these technologies collectively reshape the landscape of breast cancer diagnosis and severity assessment. An essential aspect highlighted is the synergy between advanced image processing methods and ML algorithms. This combination facilitates the automated examination of medical images, which is crucial for detecting minute anomalies indicative of breast cancer. The utilization of complex neural networks for feature extraction and pattern recognition in DL models further enhances diagnostic precision. Beyond diagnostic improvements, the abstract underscores the substantial influence of AI-driven methods on breast cancer treatment. The integration of AI not only increases diagnostic precision but also opens avenues for individualized treatment planning, marking a paradigm shift toward personalized medicine in breast cancer care. However, challenges persist, with issues related to data quality and interpretability requiring continued research efforts. Looking forward, the abstract envisions future directions for breast cancer identification and diagnosis, emphasizing the adoption of explainable AI techniques and global collaboration for data sharing. These initiatives promise to propel the field into a new era characterized by enhanced efficiency and precision in breast cancer care.
Efficient ecological function analysis and multi-objective optimizations for an endoreversible simple air refrigerator cycle
Authors: Xu Zijian , Ge Yanlin , Chen Lingen , Feng Huijun 
Published: October 2024

Abstract
Combining finite time thermodynamics and exergetic analysis, analogous to the definition of ecological efficient power for heat engines, this paper proposes a unified performance indicator for various cycles, exergy-based efficient ecological function (E

ɛ
) which is defined as product of exergy-based ecological function and coefficient of performance, and introduces it into performance optimization of endoreversible simple air refrigerator cycle coupled to constant-temperature heat reservoirs. Relations among E

ɛ
, pressure ratio (π) and heat conductance distribution ratio (u) are derived by using numerical method. The cycle performance indicators which include cooling load (R), coefficient of performance (ɛ), and exergetic loss rate (E
out/T
0) under the different maximum objective criteria are compared. Taking π as optimal variable, and taking R, ɛ, cooling load density (r), E

ɛ
and their combinations as optimization objectives, multi-objective optimizations, totally 15 optimization combinations, are performed by using NASG-II algorithm. The results demonstrate that, the maximum E

ɛ
criteria can better reflect the compromise among R, ɛ and E
out/T
0. The Pareto solution sets are majorly distributed in 2.5–20 when quadru-objective optimizations are performed. The option selected by LINMAP decision-making method is closer to ideal solution when bi-objective optimization of ɛ and r is carried out.