bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE ISLAMIC REPUBLIC OF IRAN'S FOREIGN POLICY AND CONSTRUCTION JIHAD'S DEVELOPMENTAL ACTIVITIES IN SUB-SAHARAN AFRICA
Authors: Lob Eric 
Published: April 2016

AbstractThis article adopts the theoretical framework of complex realism to trace the evolution of the Islamic Republic of Iran's foreign policy and developmental activities in Africa between the 1980s and the 2000s. Contrary to common assumptions, the deradicalization of the Islamic Republic's foreign policy in Africa began not under the moderates in the early 1990s, but under the conservatives in the mid-1980s. This period marked the first time that the Islamic Republic instrumentalized development to advance its strategic interests in Africa—a policy that has continued despite the factionalization of Iran's political elite. Based on one year of archival research and interviews in Iran, this article is the first to investigate the history and activities of the Islamic Republic's rural development organization, Construction Jihad, in Africa. It posits that development, instead of arms or ideology, has enabled Iran to make the farthest inroads into the continent due to Africa's sizeable agrarian economies, widespread rural poverty, and formidable developmental challenges.
The Sanskrit Udānavarga and the Tocharian B Udānastotra: a window on the relationship between religious and popular language on the northern Silk Road
Authors: Peyrot Michaël 
Published: April 2016

AbstractThe majority of the Sanskrit Buddhist manuscripts from the northern part of the Tarim Basin in present-day Xinjiang (China) were found in an area where the local languages Tocharian A and B were spoken. In this article, the interplay of Sanskrit, the religious language, and Tocharian, the popular language, is investigated based on the example of the relationship between the Sanskrit Udānavarga and the Tocharian B Udānastotra. To this end, a reconstruction of the text of the introduction to the Udānastotra is attempted, which forms the transition from the Udānavarga to the Udānastotra proper. It is argued that this Tocharian B text was found in otherwise Sanskrit manuscripts, which suggests that speakers of Tocharian preferred certain doctrinal texts in Sanskrit.
I.—On Kuiper's Theory of the Origin of the Solar System
Authors: ter Haar D. 
Published: April 2016

SynopsisKuiper's recent theory of the origin of the solar system is criticised on several grounds. Firstly, it is pointed out that the empirical relation between the ratio of the masses of two consecutive planets (satellites) on the one hand and the ratio of their distances from the sun (primary) on the other hand is not the one discussed by Kuiper. Secondly, it is shown that the densities needed for a successful application of Kuiper's theory are probably not attained in the system considered by him. Finally, some other points are discussed which enter into most theories about the origin of the solar system.
Learning to Govern Oneself: Environmental Education Pedagogy and the Formation of an Environmental Subject
Authors: Ferreira Jo-Anne 
Published: April 2016

AbstractThis paper uses the work of Weber and Foucault to explore the ways in which environmental education may operate as a site for forming and maintaining particular ethical competencies which most environmental educators argue are necessary in order to live in an ‘environmentally sustainable' manner. Environmental education practices, as evidenced in the Earthkeepers program, are examined to show how environmental education may be working in quite particular ways to construct specific ethical abilities and competencies in students. It is argued that we need to be far more concerned with and aware of the actual means we use to encourage students to live in an ‘environmentally sustainable' fashion.
Success and Complication Rates with Prehospital Placement of an Esophageal-Tracheal Combitube as a Rescue Airway
Authors: Calkins Thomas R. , Miller Ken , Langdorf Mark I. 
Published: April 2016

AbstractIntroduction:Previous studies have proven the success of the EsophagealTracheal Combitube (ETC) as a primary airway, but not as a rescue airway.Objective:The object of this study was to observe success and complication rates of paramedic placement of an ETC as a rescue airway, and to compare success rates with endotracheal tube (ETT) intubation. The primary outcome indicator was placement with successful ventilation. Complication rates, esophageal placement, and return of spontaneous circulation (ROSC) were secondary measures.Methods:A retrospective review of the records of patients who had ETC attempts by Emergency Medical Services (EMS) was conducted for a period of three years. Complications were defined a priori. The ETC is used primarily as rescue airway for a failed attempt at an endotracheal tube (ETT) intubation. A control group for ETT placements was drawn from the EMS quality assurance (QA) database for the same period.Results:Esophageal-Tracheal Combitube insertion was attempted on 162 patients, of which, 113 (70%) were successful, 46 (28%) failed, and the outcome of three (2%) was not recorded. Inability to place the ETC occurred in 29 (18%) patients, and accounted for 48% (22/46) of failures. The use of the ETC caused dental trauma in one patient, and one placement of the ETC was related to the onset of subcutaneous emphysema. Blood in the ETC from active upper gatrointestinal bleeding occurred in nine patients (6%), and four tubes (3%) became dislodged en route to the hospital. The a priori complication rate was 44/162 (27%). Inability to determine placement of the ETC due to emesis from both ports occurred in 21 cases. Combining these problems with the a priori complications, the overall rate was 40% (65/162). EsophagealTracheal Combitube location was noted in a subset of 90 charts, of which, 76 (84%) were esophageal, and 14 (16%) were tracheal. Thirteen of 126 (10%) patients in cardiac arrest had return of spontaneous circulation (ROSC) in the field after placement of the ETC. An ETT was attempted in 128 control patients, of which, 107 (84%) were successful, 21 (16%) failed (odds ratio (OR) for ETT vs. ETC = 2.1; 95% CI = 1.12–3.86).Conclusion:Despite a low ROSC rate, the complication and success rates of ETC are acceptable for a rescue airway device. Tracheal placement of the Combitube is uncommon, but requires fail-safe discrimination. Similar to previous reports, the success ratio for ETT was greater than for the ETC.
Mass Gathering Medical Care: A Twenty-Five Year Review
Authors: Michael John A. , Barbera Joseph A. 
Published: April 2016

AbstractIntroduction:The purpose of this study was to critically review the provision of medical care at mass gatherings as described in 25 years of case reports. Specifically measured was the relationship between the size of a mass gathering and the frequency of patients seeking medical aid and the effects of certain event characteristics on this relationship.Methods:Data were obtained through a retrospective literature review. Medline and CINHAL computerized databases were searched for English language articles using several keywords: “mass gathering”, “concert”, “festival”, “Olympics”, “crowd”, “riot”, “stadium”, “sports”, “games”, “papal”, and “football”. Only articles containing complete information on the number of spectators, number of patients, type, location, and duration of the mass gathering were included in the primary analysis. As available, additional information was added including the described weather patterns, number of patients transported to a hospital, and number of patients suffering a cardiac arrest. Thirty-five of the approximately 100 articles reviewed, met these criteria.Results:A Spearman Rank Correlation Coefficient was calculated for number of spectators and patients and a significant relationship was identified (p = 0.0001). Mann-Whitney U-tests indicated that papal masses (p = 0.04), rock concerts (p = 0.005), hot climatic conditions (p = 0.03) and events held in the British Commonwealth (p = 0.03) had a significantly higher frequency of patient visits. Significantly more cardiac arrests occurred at papal masses (p = 0.04) and sporting events (p = 0.0002).Conclusion:Type of event, country, weather, and the size of the mass gathering had a significant effect on the numbers of spectators seeking medical care. A uniform classification scheme is necessary for future prospective studies of mass gatherings.
Clinical Features and Treatment Characteristics of Compulsive Hoarding in Japanese Patients with Obsessive-Compulsive Disorder
Authors: Matsunaga Hisato , Hayashida Kazuhisa , Kiriike Nobuo , Nagata Toshihiko , Stein Dan J. 
Published: April 2016

ABSTRACTIntroduction:Compulsive hoarding has been studied primarily in Western countries. Here we sought to examine compulsive hoarding in Japanese patients with obsessive-compulsive disorder (OCD). The heterogeneous nature of hoarding was also investigated.Methods:One hundred and sixty-eight OCD outpatients were initially assessed to determine the presence or absence of compulsive hoarding, and whether hoarding was primary or secondary to another symptom dimension for which they had received treatment for 1 year.Results:Of the participants, 54 patients were found to have compulsive hoarding. Hoarders were significantly more likely than non-hoarding patients to have more severe psychopathology including elevated severity of OCD symptoms, poorer insight, higher prevalence of comorbid schizotypal or obsessive-compulsive personality disorder, closer association with symmetry dimension, and poorer treatment outcome. Comparisons of subjects with primary and secondary hoarding found that the former group had more severe clinical features, while the latter group hoarded a wider variety of items, including apparently bizarre ones.Conclusion:The prevalence and clinical characteristics of compulsive hoarding in OCD subjects was similar to those reported in Western countries, supporting its trans-cultural consistency. The distinction between primary and secondary hoarding in OCD is clinically useful, and may contribute to the debate about whether hoarding should be a separate diagnostic entity.
X-Ray Absorption Correction for Quantitative Scanning Transmission Electron Microscopic Energy-Dispersive X-Ray Spectroscopy of Spherical Nanoparticles
Authors: Slater Thomas , Chen Yiqiang , Auton Gregory , Zaluzec Nestor , Haigh Sarah 
Published: April 2016

AbstractA new method to perform X-ray absorption correction for spherical particles in quantitative energy-dispersive X-ray spectroscopy in the scanning transmission electron microscope is presented. An absorption correction factor is derived and simulated data is presented encompassing a range of X-ray absorption conditions. Theoretical calculations are compared with experimental data of X-ray counts from Au nanoparticles to verify the derived methodology. The effect of detector elevation angle is considered and a comparison with thin-film absorption correction is included.
KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages
Authors: Grimaldi A , D'Alessandro G , Golia M T , Grössinger E M , Di Angelantonio S , Ragozzino D , Santoro A , Esposito V , Wulff H , Catalano M , Limatola C 
Published: April 2016

AbstractAmong the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype. Both glioma and infiltrating M/MΦ cells express the Ca2+-activated K+ channel (KCa3.1), and the inhibition of KCa3.1 activity on glioma cells reduces tumor infiltration in the healthy brain parenchyma. We wondered whether KCa3.1 inhibition could prevent the acquisition of a pro-tumor phenotype by M/MΦ cells, thus contributing to reduce glioma development. With this aim, we studied microglia cultured in glioma-conditioned medium or treated with IL-4, as well as M/MΦ cells acutely isolated from glioma-bearing mice and from human glioma biopsies. Under these different conditions, M/MΦ were always polarized toward an anti-inflammatory state, and preventing KCa3.1 activation by 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34), we observed a switch toward a pro-inflammatory, antitumor phenotype. We identified FAK and PI3K/AKT as the molecular mechanisms involved in this phenotype switch, activated in sequence after KCa3.1. Anti-inflammatory M/MΦ have higher expression levels of KCa3.1 mRNA (kcnn4) that are reduced by KCa3.1 inhibition. In line with these findings, TRAM-34 treatment, in vivo, significantly reduced the size of tumors in glioma-bearing mice. Our data indicate that KCa3.1 channels are involved in the inhibitory effects exerted by the glioma microenvironment on infiltrating M/MΦ, suggesting a possible role as therapeutic targets in glioma.
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate
Authors: Van de Walle Inge , Dolens Anne-Catherine , Durinck Kaat , De Mulder Katrien , Van Loocke Wouter , Damle Sagar , Waegemans Els , De Medts Jelle , Velghe Imke , De Smedt Magda , Vandekerckhove Bart , Kerre Tessa , Plum Jean , Leclercq Georges , Rothenberg Ellen V. , Van Vlierberghe Pieter , Speleman Frank , Taghon Tom 
Published: April 2016

AbstractThe gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at least two sequential developmental stages. Following Notch1-dependent T-cell lineage specification during which the first T-cell lineage genes are expressed and myeloid and dendritic cell potential is lost, T-cell specific transcription factors subsequently induce T-cell commitment by repressing residual natural killer (NK)-cell potential. How these processes are regulated in human is poorly understood, especially since efficient T-cell lineage commitment requires a reduction in Notch signalling activity following T-cell specification. Here, we show that GATA3, in contrast to TCF1, controls human T-cell lineage commitment through direct regulation of three distinct processes: repression of NK-cell fate, upregulation of T-cell lineage genes to promote further differentiation and restraint of Notch activity. Repression of the Notch1 target gene DTX1 hereby is essential to prevent NK-cell differentiation. Thus, GATA3-mediated positive and negative feedback mechanisms control human T-cell lineage commitment.
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
Authors: Yosef Reut , Pilpel Noam , Tokarsky-Amiel Ronit , Biran Anat , Ovadya Yossi , Cohen Snir , Vadai Ezra , Dassa Liat , Shahar Elisheva , Condiotti Reba , Ben-Porath Ittai , Krizhanovsky Valery 
Published: April 2016

AbstractSenescent cells, formed in response to physiological and oncogenic stresses, facilitate protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells in tissues contributes to age-related pathologies. Resistance of senescent cells to apoptotic stimuli may contribute to their accumulation, yet the molecular mechanisms allowing their prolonged viability are poorly characterized. Here we show that senescent cells upregulate the anti-apoptotic proteins BCL-W and BCL-XL. Joint inhibition of BCL-W and BCL-XL by siRNAs or the small-molecule ABT-737 specifically induces apoptosis in senescent cells. Notably, treatment of mice with ABT-737 efficiently eliminates senescent cells induced by DNA damage in the lungs as well as senescent cells formed in the epidermis by activation of p53 through transgenic p14ARF. Elimination of senescent cells from the epidermis leads to an increase in hair-follicle stem cell proliferation. The finding that senescent cells can be eliminated pharmacologically paves the way to new strategies for the treatment of age-related pathologies.
Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming
Authors: Moreau Thomas , Evans Amanda L. , Vasquez Louella , Tijssen Marloes R. , Yan Ying , Trotter Matthew W. , Howard Daniel , Colzani Maria , Arumugam Meera , Wu Wing Han , Dalby Amanda , Lampela Riina , Bouet Guenaelle , Hobbs Catherine M. , Pask Dean C. , Payne Holly , Ponomaryov Tatyana , Brill Alexander , Soranzo Nicole , Ouwehand Willem H. , Pedersen Roger A. , Ghevaert Cedric 
Published: April 2016

AbstractThe production of megakaryocytes (MKs)—the precursors of blood platelets—from human pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine. Here we describe an original approach for the large-scale generation of MKs in chemically defined conditions using a forward programming strategy relying on the concurrent exogenous expression of three transcription factors: GATA1, FLI1 and TAL1. The forward programmed MKs proliferate and differentiate in culture for several months with MK purity over 90% reaching up to 2 × 105 mature MKs per input hPSC. Functional platelets are generated throughout the culture allowing the prospective collection of several transfusion units from as few as 1 million starting hPSCs. The high cell purity and yield achieved by MK forward programming, combined with efficient cryopreservation and good manufacturing practice (GMP)-compatible culture, make this approach eminently suitable to both in vitro production of platelets for transfusion and basic research in MK and platelet biology.
Near optimal graphene terahertz non-reciprocal isolator
Authors: Tamagnone Michele , Moldovan Clara , Poumirol Jean-Marie , Kuzmenko Alexey B. , Ionescu Adrian M. , Mosig Juan R. , Perruisseau-Carrier Julien 
Published: April 2016

AbstractIsolators, or optical diodes, are devices enabling unidirectional light propagation by using non-reciprocal optical materials, namely materials able to break Lorentz reciprocity. The realization of isolators at terahertz frequencies is a very important open challenge made difficult by the intrinsically lossy propagation of terahertz radiation in current non-reciprocal materials. Here we report the design, fabrication and measurement of a terahertz non-reciprocal isolator for circularly polarized waves based on magnetostatically biased monolayer graphene, operating in reflection. The device exploits the non-reciprocal optical conductivity of graphene and, in spite of its simple design, it exhibits almost 20 dB of isolation and only 7.5 dB of insertion loss at 2.9 THz. Operation with linearly polarized light can be achieved using quarter-wave plates as polarization converters. These results demonstrate the superiority of graphene with respect to currently used terahertz non-reciprocal materials and pave the way to a novel class of optimal non-reciprocal devices.
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
Authors: Hosokawa Hiroyuki , Tanaka Tomoaki , Endo Yusuke , Kato Miki , Shinoda Kenta , Suzuki Akane , Motohashi Shinichiro , Matsumoto Masaki , Nakayama Keiichi I. , Nakayama Toshinori 
Published: April 2016

AbstractTh2 cells produce Th2 cytokines such as IL-4, IL-5 and IL-13, but repress Th1 cytokine IFNγ. Recent studies have revealed various distinct memory-type Th2 cell subsets, one of which produces a substantial amount of IFNγ in addition to Th2 cytokines, however it remains unclear precisely how these Th2 cells produce IFNγ. We herein show that phosphorylation of Gata3 at Ser308, Thr315 and Ser316 induces dissociation of a histone deacetylase Hdac2 from the Gata3/Chd4 repressive complex in Th2 cells. We also identify Akt1 as a Gata3-phosphorylating kinase, and the activation of Akt1 induces derepression of Tbx21 and Ifng expression in Th2 cells. Moreover, T-bet-dependent IFNγ expression in IFNγ-producing memory Th2 cells appears to be controlled by the phosphorylation status of Gata3 in human and murine systems. Thus, this study highlights the molecular basis for posttranslational modifications of Gata3 that control the regulation of IFNγ expression in memory Th2 cells.
Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein
Authors: Bokori-Brown Monika , Martin Thomas G. , Naylor Claire E. , Basak Ajit K. , Titball Richard W. , Savva Christos G. 
Published: April 2016

AbstractLysenin from the coelomic fluid of the earthworm Eisenia fetida belongs to the aerolysin family of small β-pore-forming toxins (β-PFTs), some members of which are pathogenic to humans and animals. Despite efforts, a high-resolution structure of a channel for this family of proteins has been elusive and therefore the mechanism of activation and membrane insertion remains unclear. Here we determine the pore structure of lysenin by single particle cryo-EM, to 3.1 Å resolution. The nonameric assembly reveals a long β-barrel channel spanning the length of the complex that, unexpectedly, includes the two pre-insertion strands flanking the hypothetical membrane-insertion loop. Examination of other members of the aerolysin family reveals high structural preservation in this region, indicating that the membrane-insertion pathway in this family is conserved. For some toxins, proteolytic activation and pro-peptide removal will facilitate unfolding of the pre-insertion strands, allowing them to form the β-barrel of the channel.
Helical X-ray phase-contrast computed tomography without phase stepping
Authors: Marschner M. , Willner M. , Potdevin G. , Fehringer A. , Noël P. B. , Pfeiffer F. , Herzen J. 
Published: April 2016

AbstractX-ray phase-contrast computed tomography (PCCT) using grating interferometry provides enhanced soft-tissue contrast. The possibility to use standard polychromatic laboratory sources enables an implementation into a clinical setting. Thus, PCCT has gained significant attention in recent years. However, phase-contrast CT scans still require significantly increased measurement times in comparison to conventional attenuation-based CT imaging. This is mainly due to a time-consuming stepping of a grating, which is necessary for an accurate retrieval of the phase information. In this paper, we demonstrate a novel scan technique, which directly allows the determination of the phase signal without a phase-stepping procedure. The presented work is based on moiré fringe scanning, which allows fast data acquisition in radiographic applications such as mammography or in-line product analysis. Here, we demonstrate its extension to tomography enabling a continuous helical sample rotation as routinely performed in clinical CT systems. Compared to standard phase-stepping techniques, the proposed helical fringe-scanning procedure enables faster measurements, an extended field of view and relaxes the stability requirements of the system, since the gratings remain stationary. Finally, our approach exceeds previously introduced methods by not relying on spatial interpolation to acquire the phase-contrast signal.
Flocculated meltwater particles control Arctic land-sea fluxes of labile iron
Authors: Markussen Thor Nygaard , Elberling Bo , Winter Christian , Andersen Thorbjørn Joest 
Published: April 2016

AbstractGlacial meltwater systems supply the Arctic coastal ocean with large volumes of sediment and potentially bioavailable forms of iron, nitrogen and carbon. The particulate fraction of this supply is significant but estuarine losses have been thought to limit the iron supply from land. Here, our results reveal how flocculation (particle aggregation) involving labile iron may increase horizontal transport rather than enhance deposition close to the source. This is shown by combining field observations in Disko Fjord, West Greenland and laboratory experiments. Our data show how labile iron affects floc sizes, shapes and densities and consequently yields low settling velocities and extended sediment plumes. We highlight the importance of understanding the flocculation mechanisms when examining fluxes of meltwater transported iron in polar regions today and in the future and we underline the influence of terrestrial hotspots on the nutrient and solute cycles in Arctic coastal waters.