bluuebunny/crossref_metadata_2025_split huggingface dataset:
The oldest pottery in hunter-gatherer communitiesand models of Neolithisation of Eastern Europe
Authors: Mazurkevich A. , Dolbunova Ekaterina 
Published: December 2015

The characteristics of the oldest pottery in Eastern Europe, located in three main regions, the Lower Don and Lower and Middle Volga, and a description of different Early Neolithic types of pottery production are described in this article. We present ideas on how and when the oldest pottery traditions were distributed through Eastern Europe according to radiocarbon dates. Also, models of the Neolithisation of Eastern Europe are suggested based on archaeological evidence and absolute chronology.
Fifth and fourth millennium BC in north-western Iran: Dalma and Pisdeli revisited
Authors: Abedi Akbar , Omrani Behrooz , Karimifar Azam 
Published: December 2015

This paper discusses the nature of Dalma and Pisdeli cultures, their regional and interregional interactions and expansions in 5th millennium BC. It discusses old and new excavations and surveys as well. According to the importance of the material from these periods found at newly-excavated sites such as Kul Tepe Jolfa, Dava Göz Khoy, Lavin Tepe, and Qosha Tepe, we briefly describe the main stratigraphic and material data from these sites. Old and new data from excavations and surveys eventually lead us to a new chronological table for the 5th millennium BC in north/western (NW) Iran. The implications of the finds are discussed along with their limitations and future research directions.
Preceramic, Aceramic or Early Ceramic? The radiocarbon dated beginning of the Neolithic in the Aegean
Authors: Reingruber Agathe 
Published: December 2015

The Pre-Pottery-Neolithic refers to a period in the Eastern Mediterranean when ceramic containers were not yet in use (although small objects made of clay were already being created). This concept, which reflects a specific and quite unique stage in the development of human history, was introduced to Aegean prehistory under the term of Preceramic during the 1950’s (e.g., in Argissa Magoula and Sesklo). Shortly thereafter, a different term, the Aceramic, was applied in the Aegean (e.g., in Knossos) for levels devoid of pottery, although ceramic products were supposedly used in the wider region. In some cases, the thin levels interpreted as Preceramic or as Aceramic contained sherds that were regarded as being intrusive from above (e.g., Argissa-Magoula, Franchthi Cave). The new sequences of radiocarbon dates allow a more precise description of this early period and thereby contribute, not least, also to the clarification of terminological issues.
Aandacht voor de morele dimensie van toezicht
Authors: Seekles Wike , Widdershoven Guy , Robben Paul , van Dalfsen Gonny , Molewijk Bert 
Published: December 2015

Aandacht voor de morele dimensie van toezicht. Een onderzoek naar de inzet van moreel beraad voor inspecteurs
Inspecteurs en toezichthoudende organisaties staan dagelijks voor lastige beslissingen. Het bepalen van wat uiteindelijk ‘goed toezicht’ is, vergt naast regelgeving, vakinhoudelijke kennis en protocollen ook morele afwegingen. In inspectieorganisaties is doorgaans geen tijd en expertise voor een methodische reflectie op de morele dimensie van het werk. Om te onderzoeken of moreel beraad een bijdrage kan leveren aan de omgang met morele vragen in de dagelijkse toezichtpraktijk is een exploratieve pilotstudie uitgevoerd binnen de Inspectie voor de Gezondheidszorg.
Application of the Variety-Generator Approach to Searches of Personal Names in Bibliographic Data Bases--Part 1. Microstructure of Personal Authors' Names
Authors: Fokker Dirk W. , Lynch Michael F. 
Published: December 2015

Conventional approaches to processing records of linguistic origin for storage and retrieval tend to regard the data as immutable. The data generally exhibit great variety and disparate frequency distributions, which are largely ignored and which entail either the storage of extensive lists of items or the use of complex numerical algorithms such as hash coding. The results in each case are far from ideal.
The variety-generator approach seeks to reflect the microstructure of data elements in their description for storage and search, and takes advantage of the consistency of statistical characteristics of data elements in homogeneous data bases.
In this paper, the application of the variety-generator approach to the description of personal author names from the INSPEC data base by means of small sets of keys is detailed. It is shown that high degrees of partitioning of names can be obtained by key-sets generated from the initial characters of surnames, fmm the terminal characters of surnames, and from the initials.
The implications of the findings for computer-based bibliographical informationsystems are discussed.
« A la recherche du temps perdu ». La transmission d’objets de luxe de père en fils, entre cadeau et fardeau
Authors: Kessous Aurélie , de Barnier Virginie , Valette-Florence Pierre 
Published: December 2015

Cet article s’intéresse à un thème récurrent de la communication publicitaire des horlogers de luxe : la transmission de montres de père en fils. Il appréhende le double problème auquel sont confrontées les marques de montres de luxe : conserver une clientèle d’hommes mûrs et conquérir une cible plus jeune, leurs fils. Une étude qualitative par entretiens, menée auprès de 15 dyades pères/fils, permet d’identifier les motivations du don et les conséquences de la réception. En amont de retombées managériales importantes, ce travail clarifie la distinction entre don et transmission et contribue à une meilleure compréhension du processus de sacralisation des objets de luxe. Les résultats présentent le don comme l’affirmation du pouvoir paternel sur le fils et la réception comme l’acceptation d’une série d’obligations formelles envers le père. Des pistes stratégiques permettant aux marques de luxe d’asseoir un positionnement transgénérationnel masculin sans générer de sentiments négatifs chez les récipiendaires sont formulées.
L’appropriation des clients dans les boutiques de marque de luxe : proposition d’une typologie
Authors: Welté Jean-Baptiste , Ochs Lionel 
Published: December 2015

Cette recherche s’intéresse à la manière dont les consommateurs s’approprient les boutiques de marque de luxe. Elle propose une typologie de consommateurs selon leur appropriation de cet espace en magasin. Quatre catégories ont été identifiées : les « déambulateurs », les « aspirants », les « conquérants » et les « habitués ». Leur appropriation physique en boutique évolue en fonction de leur appropriation de la culture du luxe. La stratégie de distribution de la marque peut donc être adaptée en fonction de ces différents clients en distinguant des boutiques « accessibles » et « exclusives ».
Proposition d’une nouvelle segmentation des jeunes consommateurs chinois des produits de luxe
Authors: Mo Tingting 
Published: December 2015

Les consommateurs chinois donnent souvent l’impression d’avoir tous la « fièvre du luxe », mais en réalité ce marché est très hétérogène. A partir d’une recherche empirique effectuée sur un échantillon de convenance de 338 consommateurs chinois de 18 à 34 ans, - groupe de consommateurs très important en Chine -, une segmentation affinée des jeunes consommateurs de luxe en Chine est proposée. Cinq segments et leurs différents profils démographiques, comportementaux et psychologiques sont identifiés. Complétés par des cas et des exemples cohérents et à jour sur ce marché, les résultats de cette segmentation permettent de suggérer des recommandations.
Fluïdesa semàntica i variació regional en hidrònims de les comarques valencianes de parla xurra
Authors: Garcia i Osuna Antonio 
Published: December 2015

Con el presente artículo pretendemos ejemplificar mediante el estudio de los hidrónimos naturales y artificiales, tanto de los genéricos toponímicos como de los pretopónimos, de dos de los rasgos que caracterizan el léxico hidronímico: la fluidez semántica –un significado es realizado mediante más de un significante y, a la vez, un significante, por más de un significado. Estos dos rasgos ya han sido señalados por el investigador norteamericano Thomas Glick refiriéndose al estudio del léxico valenciano del riego.Estos rasgos son referidos dentro del contexto del habla xurra de las comarcas valencianas lingüísticamente de base castellanoaragonesa. En el seno de estas comarcas, se estudia el disparo de la variación regional, no solamente con varios resultados léxicos, sino también formales, fruto del contacto de lenguas y del adstrato árabe hispánico. A guisa de ejemplo de estos cambios formales, ofrecemos los cuatro resultados –hocino/hochino/hogina/fuchino– correspondientes al étimo latino F?CE+ *INU, ‘garganta, desfiladero’.Palabras clave: habla xurra; hidrónimos; variación regional; fluidez semántica; adstrato.
A formação acadêmica do fisioterapeuta para sua atuação na gestão em saúde
Authors: Costa Carla Regina Soares , Montagna Erik 
Published: December 2015

Introdução: A formação do profissional fisioterapeuta declara em suas diretrizes a necessidade de preparar o egresso para desempenhar funções de gestor. Entretanto, não define com clareza qual a natureza dessa atuação, tampouco prescreve ou recomenda componentes curriculares para tanto. Objetivo: Verificar nos cursos de fisioterapia mais bem colocados segundo índices oficiais de desempenho quais abordagens eram utilizadas para essa demanda. Métodos: Por meio da análise de ementas e currículos dos dez melhores cursos de fisioterapia segundo o Índice Geral de Cursos (IGC), foi feito um levantamento das iniciativas declaradas em documentos oficiais que atendessem às demandas das Diretrizes Curriculares para fisioterapia. Resultados: Mostraram que apesar da clara indicação nas diretrizes, não existe de forma organizada e sistematizada o assunto “gestão” em disciplinas, módulos ou unidades didáticas. Conclusão: Tal fato revela o descompasso entre o declarado em documentos oficiais e o que é praticado em cursos considerados modelo segundo o IGC.
ZnO/(Hf,Zr)O2/ZnO-trilayered nanowire capacitor structure fabricated solely by metalorganic chemical vapor deposition
Authors: Fujisawa Hironori , Kuwamoto Kei , Nakashima Seiji , Shimizu Masaru 
Published: December 2015

Abstract
HfO2-based thin films are one of the key dielectric and ferroelectric materials in Si-CMOS LSIs as well as in oxide electronic nanodevices. In this study, we demonstrated the fabrication of a ZnO/(Hf,Zr)O2/ZnO-trilayered nanowire (NW) capacitor structure solely by metalorganic chemical vapor deposition (MOCVD). 15-nm-thick dielectric (Hf,Zr)O2 and 40-nm-thick top ZnO electrode layers were uniformly grown by MOCVD on a ZnO NW template with average diameter, length, and aspect ratio of 110 nm, 10 µm, and ∼90, respectively. The diameter and aspect ratio of the resultant trilayerd NWs are 200–300 nm and above 30, respectively. The crystalline phase of HfO2 and stacked the structure are also discussed.
Distributed Kalman filters with adaptive strategy for linear time‐varying interconnected systems
Authors: Heydari Mahdi , Demetriou Michael A. 
Published: December 2015

SummaryWe consider the problem of distributed state estimation over a sensor network in which a set of nodes collaboratively estimates the state of a continuous‐time linear time‐varying system. In particular, our work focuses on the benefits of weight adaptation of the interconnection gains in distributed Kalman filters. To this end, an adaptation strategy is proposed with the adaptive laws derived via a Lyapunov‐redesign approach. The justification for the gain adaptation stems from a desire to adapt the pairwise difference of state estimates as a function of their agreement, thereby enforcing an interconnection‐dependent gain. In the proposed scheme, an adaptive gain for each pairwise difference of the interconnection terms is used in order to address edge‐dependent differences in the state estimates. Accounting for node‐specific differences, a special case of the scheme is also presented, where it uses a single adaptive gain in each node estimate and which uniformly penalizes all pairwise differences of state estimates in the interconnection term. The filter gains can be designed either by standard Kalman filter or Luenberger observer to construct the adaptive distributed Kalman filter or adaptive distributed Luenberger observer. Stability of the schemes has been shown, and it is not restricted by the graph topology and therefore the schemes are applicable to both directed and undirected graphs. The proposed algorithms offer a significant reduction in communication costs associated with information flow by the nodes. Finally, numerical studies are presented to illustrate the performance and effectiveness of the proposed adaptive distributed Kalman filters. Copyright © 2015 John Wiley & Sons, Ltd.
A decentralized adaptive algorithm for fair allocation of a shared resource
Authors: Bhaya Amit , Kaszkurewicz Eugenius 
Published: December 2015

SummaryThis paper views the classical Chiu–Jain algorithm, originally proposed for congestion control of network links, as a decentralized algorithm for the fair allocation of a total of c units of a shared resource among n users. A new analysis is given of the general case of additive increase and multiplicative decrease (AIMD) dynamics, from the perspective of virtual equilibria and variable structure systems, leading to a better understanding of the Chiu–Jain algorithm, which is one example of AIMD dynamics. It is shown that the variable structure discrete dynamical system that describes the evolution of the share of each individual, starting from an arbitrary initial allocation, always attains a neighbourhood of the fair share (c/n) for each user, under the assumption that the latter is known. Subsequently, a new adaptive version of the algorithm, called adaptive AIMD, is described, with the same property of converging to the fair share, without assuming that it is known. Simulations that show the behaviour and advantages of the proposed adaptive AIMD adaptive algorithm are given. Copyright © 2015 John Wiley & Sons, Ltd.
Synthesis and Use of a Phosphonate Amidine to Generate an Anti‐Phosphoarginine‐Specific Antibody
Authors: Fuhrmann Jakob , Subramanian Venkataraman , Thompson Paul R. 
Published: December 2015

AbstractProtein arginine phosphorylation is a post‐translational modification (PTM) that is important for bacterial growth and virulence. Despite its biological relevance, the intrinsic acid lability of phosphoarginine (pArg) has impaired studies of this novel PTM. Herein, we report for the first time the development of phosphonate amidines and sulfonate amidines as isosteres of pArg and then use these mimics as haptens to develop the first high‐affinity sequence independent anti‐pArg specific antibody. Employing this anti‐pArg antibody, we further showed that arginine phosphorylation is induced in Bacillus subtilis during oxidative stress. Overall, we expect this antibody to see widespread use in analyzing the biological significance of arginine phosphorylation. Additionally, the chemistry reported here will facilitate the generation of pArg mimetics as highly potent inhibitors of the enzymes that catalyze arginine phosphorylation/dephosphorylation.
Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand‐Based Virtual Screening Method
Authors: Simonin Céline , Awale Mahendra , Brand Michael , van Deursen Ruud , Schwartz Julian , Fine Michael , Kovacs Gergely , Häfliger Pascal , Gyimesi Gergely , Sithampari Abilashan , Charles Roch‐Philippe , Hediger Matthias A. , Reymond Jean‐Louis 
Published: December 2015

AbstractHerein, we report the discovery of the first potent and selective inhibitor of TRPV6, a calcium channel overexpressed in breast and prostate cancer, and its use to test the effect of blocking TRPV6‐mediated Ca2+‐influx on cell growth. The inhibitor was discovered through a computational method, xLOS, a 3D‐shape and pharmacophore similarity algorithm, a type of ligand‐based virtual screening (LBVS) method described briefly here. Starting with a single weakly active seed molecule, two successive rounds of LBVS followed by optimization by chemical synthesis led to a selective molecule with 0.3 μM inhibition of TRPV6. The ability of xLOS to identify different scaffolds early in LBVS was essential to success. The xLOS method may be generally useful to develop tool compounds for poorly characterized targets.
Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes
Authors: Wu Lindsay E. , Levina Aviva , Harris Hugh H. , Cai Zhonghou , Lai Barry , Vogt Stefan , James David E. , Lay Peter A. 
Published: December 2015

AbstractChromium(III) nutritional supplements are widely consumed for their purported antidiabetic activities. X‐ray fluorescence microscopy (XFM) and X‐ray absorption near‐edge structure (XANES) studies have now shown that non‐toxic doses of [Cr3O(OCOEt)6(OH2)3]+ (A), a prospective antidiabetic drug that undergoes similar H2O2 induced oxidation reactions in the blood as other Cr supplements, was also oxidized to carcinogenic CrVI and CrV in living cells. Single adipocytes treated with A had approximately 1 μm large Cr hotspots containing CrIII, CrV, and CrVI (primarily CrVI thiolates) species. These results strongly support the hypothesis that the antidiabetic activity of CrIII and the carcinogenicity of CrVI compounds arise from similar mechanisms involving highly reactive CrVI and CrV intermediates, and highlight concerns over the safety of CrIII nutritional supplements.
Enzyme‐Responsive Polymeric Vesicles for Bacterial‐Strain‐Selective Delivery of Antimicrobial Agents
Authors: Li Yamin , Liu Guhuan , Wang Xiaorui , Hu Jinming , Liu Shiyong 
Published: December 2015

AbstractAntimicrobial resistance poses serious public health concerns and antibiotic misuse/abuse further complicates the situation; thus, it remains a considerable challenge to optimize/improve the usage of currently available drugs. We report a general strategy to construct a bacterial strain‐selective delivery system for antibiotics based on responsive polymeric vesicles. In response to enzymes including penicillin G amidase (PGA) and β‐lactamase (Bla), which are closely associated with drug‐resistant bacterial strains, antibiotic‐loaded polymeric vesicles undergo self‐immolative structural rearrangement and morphological transitions, leading to sustained release of antibiotics. Enhanced stability, reduced side effects, and bacterial strain‐selective drug release were achieved. Considering that Bla is the main cause of bacterial resistance to β‐lactam antibiotic drugs, as a further validation, we demonstrate methicillin‐resistant S. aureus (MRSA)‐triggered release of antibiotics from Bla‐degradable polymeric vesicles, in vitro inhibition of MRSA growth, and enhanced wound healing in an in vivo murine model.
Catalytic Molecular Imaging of MicroRNA in Living Cells by DNA‐Programmed Nanoparticle Disassembly
Authors: He Xuewen , Zeng Tao , Li Zhi , Wang Ganglin , Ma Nan 
Published: December 2015

AbstractMolecular imaging is an essential tool for disease diagnostics and treatment. Direct imaging of low‐abundance nucleic acids in living cells remains challenging because of the relatively low sensitivity and insufficient signal‐to‐background ratio of conventional molecular imaging probes. Herein, we report a class of DNA‐templated gold nanoparticle (GNP)–quantum dot (QD) assembly‐based probes for catalytic imaging of cancer‐related microRNAs (miRNA) in living cells with signal amplification capacity. We show that a single miRNA molecule could catalyze the disassembly of multiple QDs with the GNP through a DNA‐programmed thermodynamically driven entropy gain process, yielding significantly amplified QD photoluminescence (PL) for miRNA imaging. By combining the robust PL of QDs with the catalytic amplification strategy, three orders of magnitude improvement in detection sensitivity is achieved in comparison with non‐catalytic imaging probe, which enables facile and accurate differentiation between cancer cells and normal cells by miRNA imaging in living cells.
Moisture Battery Formed by Direct Contact of Magnesium with Foamed Polyaniline
Authors: Xie Pu , Rong Min Zhi , Zhang Ming Qiu 
Published: December 2015

AbstractThe present communication reports a concept battery made by direct contact of magnesium foil with ultralight polyaniline (PANI) foam in the absence of additional electrolyte. Electrical current is allowed to be steadily released from the junction with a specific energy of 646 mWh g−1 and specific capacity of 1247 mAh g−1. Additionally, the battery offers an environmentally friendly route of hydrogen production along with discharging. Mechanistic studies indicated that the ubiquitous galvanic corrosion combined with decomposition of adsorbed trace water in the semi‐conducting polymer foam enabled the generation of electricity, which overturns the traditional view. The higher moisture level is conducive to the discharge. This work is believed to open up new possibilities for the design of electrochemical batteries.
Synthesis of Sulfotyrosine‐Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc‐Based Solid‐Phase Strategy
Authors: Chen Wentao , Dong Jiajia , Li Suhua , Liu Yu , Wang Yujia , Yoon Leonard , Wu Peng , Sharpless K. Barry , Kelly Jeffery W. 
Published: December 2015

AbstractTyrosine O‐sulfation is a common protein post‐translational modification that regulates many biological processes, including leukocyte adhesion and chemotaxis. Many peptides with therapeutic potential contain one or more sulfotyrosine residues. We report a one‐step synthesis for Fmoc‐fluorosulfated tyrosine. An efficient Fmoc‐based solid‐phase peptide synthetic strategy is then introduced for incorporating the fluorosulfated tyrosine residue into peptides of interest. Standard simultaneous peptide‐resin cleavage and removal of the acid‐labile side‐chain protecting groups affords the crude peptides containing fluorosulfated tyrosine. Basic ethylene glycol, serving both as solvent and reactant, transforms the fluorosulfated tyrosine peptides into sulfotyrosine peptides in high yield.
Nitrous Oxide as a Hydrogen Acceptor for the Dehydrogenative Coupling of Alcohols
Authors: Gianetti Thomas L. , Annen Samuel P. , Santiso‐Quinones Gustavo , Reiher Markus , Driess Matthias , Grützmacher Hansjörg 
Published: December 2015

AbstractThe oxidation of alcohols with N2O as the hydrogen acceptor was achieved with low catalyst loadings of a rhodium complex that features a cooperative bis(olefin)amido ligand under mild conditions. Two different methods enable the formation of either the corresponding carboxylic acid or the ester. N2 and water are the only by‐products. Mechanistic studies supported by DFT calculations suggest that the oxygen atom of N2O is transferred to the metal center by insertion into the Rh−H bond of a rhodium amino hydride species, generating a rhodium hydroxy complex as a key intermediate.
Morita–Baylis–Hillman Reaction of β,β‐Disubstituted Enones: An Enantioselective Organocatalytic Approach for the Synthesis of Cyclopenta[b]annulated Arenes and Heteroarenes
Authors: Satpathi Bishnupada , Ramasastry S. S. V. 
Published: December 2015

AbstractThe first enantioselective organocatalytic intramolecular Morita–Baylis–Hillman (MBH) reaction of sterically highly demanding β,β‐disubstituted enones is presented. The MBH reaction of β,β‐disubstituted‐α,β‐unsaturated electron‐withdrawing systems was previously considered to be unfeasible. Towards this end, designer substrates, which under simple and practical reaction conditions generate a variety of cyclopenta[b]annulated arenes and heteroarenes in excellent enantiopurities and near‐quantitative yields in remarkably short reaction times, are described. The reason for the unusually facile nature of this reaction is attributed to the synergy guided and entropically favored intramolecular reaction. Further, this strategy provides easy access to a substantial number of bioactive natural products and pharmaceutically significant compounds.