bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Sensitive Electrochemical Hydrogen Peroxide Sensor Based on Iron Oxide‐Reduced Graphene Oxide‐Chitosan Modified with DNA‐Celestine Blue
Authors: Noorbakhsh Abdollah , Khakpoor Mohmmad , Rafieniya Mohammad , Sharifi Ensiyeh , Mehrasa Mohammad 
Published: January 2017

AbstractThe present study describes a novel and very sensitive electrochemical assay for determination of hydrogen peroxide (H2O2) based on synergistic effects of reduced graphene oxide‐ magnetic iron oxide nanocomposite (rGO‐Fe3O4) and celestine blue (CB) for electrochemical reduction of H2O2. rGO‐Fe3O4 nanocomposite was synthesized and characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X‐ray diffraction (XRD), electrochemical impedance spectroscopy and cyclic voltammetry. Chitosan (Chit) was used for immobilization of amino‐terminated single‐stranded DNA (ss‐DNA) molecules via a glutaraldehyde (GA) to the surface of rGO‐Fe3O4. The MTT (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) results confirmed the biocompatibility of nanocomposite. Experimental parameters affecting the ss‐DNA molecules immobilization were optimized. Finally, by accumulation of the CB on the surface of the rGO‐Fe3O4‐Chit/ssDNA, very sensitive amperometric H2O2 sensor was fabricated. The electrocatalytic activity of the rGO‐Fe3O4‐Chit/DNA‐CB electrode toward H2O2 reduction was found to be very efficient, yielding very low detection limit (DL) of 42 nM and a sensitivity of 8.51 μA/μM. Result shows that complex matrices of the human serum samples did not interfere with the fabricated sensor. The developed sensor provided significant advantages in terms of low detection limit, high stability and good reproducibility for detection of H2O2 in comparison with recently reported electrochemical H2O2 sensors.
Preliminary techno‐economic analysis of a multi‐bed series reactor as a simultaneous CF4 abatement and utilization process
Authors: Lee Boreum , Jeong Seonju , Lee Sunggeun , Jung Ho‐Young , Ryi Shin‐Kun , Lim Hankwon 
Published: January 2017

AbstractA preliminary techno‐economic analysis combining process simulation and economic analysis has been carried out to assess the feasibility of employing a new CF4 abatement and utilization process without HF effluent, where CaO was employed to convert produced HF into CaF2, a useful chemical. Moreover, the effect of employing multi‐bed series reactors compared with a single‐bed reactor on CaF2 production was analyzed using Aspen HYSYS® based on material and energy balances from process flow diagrams for three systems, a single‐bed reactor (S‐1), a two‐bed series reactor (S‐2), and a three‐bed series reactor (S‐3). From economic analysis to estimate annual operating cost savings for three systems, it was found that multi‐bed series reactors (S‐2 and S‐3) performed better than a single‐bed reactor (S‐1) due to equilibrium shift by Le Chatelier's principle leading to reduced operating temperatures to produce the same amount of CaF2 as S‐1. Consequently, annual cost savings of about 7 to 13% were obtained in S‐2 and S‐3 compared to S‐1 and this can serve as a useful guideline for the efficient system design. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd.
Correspondence between evoked and intrinsic functional brain network configurations
Authors: Bolt Taylor , Nomi Jason S. , Rubinov Mikail , Uddin Lucina Q. 
Published: January 2017

AbstractMuch of the literature exploring differences between intrinsic and task‐evoked brain architectures has examined changes in functional connectivity patterns between specific brain regions. While informative, this approach overlooks important overall functional changes in hub organization and network topology that may provide insights about differences in integration between intrinsic and task‐evoked states. Examination of changes in overall network organization, such as a change in the concentration of hub nodes or a quantitative change in network organization, is important for understanding the underlying processes that differ between intrinsic and task‐evoked brain architectures. The present study used graph‐theoretical techniques applied to publicly available neuroimaging data collected from a large sample of individuals (N = 202), and a within‐subject design where resting‐state and several task scans were collected from each participant as part of the Human Connectome Project. We demonstrate that differences between intrinsic and task‐evoked brain networks are characterized by a task‐general shift in high‐connectivity hubs from primarily sensorimotor/auditory processing areas during the intrinsic state to executive control/salience network areas during task performance. In addition, we demonstrate that differences between intrinsic and task‐evoked architectures are associated with changes in overall network organization, such as increases in network clustering, global efficiency and integration between modules. These findings offer a new perspective on the principles guiding functional brain organization by identifying unique and divergent properties of overall network organization between the resting‐state and task performance. Hum Brain Mapp 38:1992–2007, 2017. © 2017 Wiley Periodicals, Inc.
Frontoparietal activation during visual conjunction search: Effects of bottom‐up guidance and adult age
Authors: Madden David J. , Parks Emily L. , Tallman Catherine W. , Boylan Maria A. , Hoagey David A. , Cocjin Sally B. , Johnson Micah A. , Chou Ying‐hui , Potter Guy G. , Chen Nan‐kuei , Packard Lauren E. , Siciliano Rachel E. , Monge Zachary A. , Diaz Michele T. 
Published: January 2017

AbstractWe conducted functional magnetic resonance imaging (fMRI) with a visual search paradigm to test the hypothesis that aging is associated with increased frontoparietal involvement in both target detection and bottom‐up attentional guidance (featural salience). Participants were 68 healthy adults, distributed continuously across 19 to 78 years of age. Frontoparietal regions of interest (ROIs) were defined from resting‐state scans obtained prior to task‐related fMRI. The search target was defined by a conjunction of color and orientation. Each display contained one item that was larger than the others (i.e., a size singleton) but was not informative regarding target identity. Analyses of search reaction time (RT) indicated that bottom‐up attentional guidance from the size singleton (when coincident with the target) was relatively constant as a function of age. Frontoparietal fMRI activation related to target detection was constant as a function of age, as was the reduction in activation associated with salient targets. However, for individuals 35 years of age and older, engagement of the left frontal eye field (FEF) in bottom‐up guidance was more prominent than for younger individuals. Further, the age‐related differences in left FEF activation were a consequence of decreasing resting‐state functional connectivity in visual sensory regions. These findings indicate that age‐related compensatory effects may be expressed in the relation between activation and behavior, rather than in the magnitude of activation, and that relevant changes in the activation‐RT relation may begin at a relatively early point in adulthood. Hum Brain Mapp 38:2128–2149, 2017. © 2017 Wiley Periodicals, Inc.
Do Targeted Reproductive Health Services Matter? – The Impact of a Midwife Program in Indonesia
Authors: Strupat Christoph 
Published: January 2017

SummaryThis paper examines empirically whether midwives, as an integral part of the reproductive health and family planning programs in Indonesia, are effective in advising young women to delay their first birth and also influence the decision on post‐primary school attendance. Using the Indonesian Family Life Survey, I investigate the extent to which the expansion of a midwife program affects the age at first birth and the number of school years of women. My findings suggest that women who were exposed to a midwife when they have to decide on further school attendance (aged 13–20 years) delay their first birth and also stay longer in school. According to the average returns of education in Indonesia, I conclude that reproductive health services provided by midwives can generate large socioeconomic benefits by allowing young women to postpone their first birth. Copyright © 2017 John Wiley & Sons, Ltd.
Lumbar spine postures in Marines during simulated operational positions
Authors: Berry David B. , Rodríguez‐Soto Ana E. , Su Jeannie , Gombatto Sara P. , Shahidi Bahar , Palombo Laura , Chung Christine , Jensen Andrew , Kelly Karen R. , Ward Samuel R. 
Published: January 2017

ABSTRACTLow back pain has a 70% higher prevalence in members of the armed forces than in the general population, possibly due to the loads and positions soldiers experience during training and combat. Although the influence of heavy load carriage on standing lumbar spine posture in this population is known, postures in other operationally relevant positions are unknown. Therefore, the purpose of this study was to characterize the effect of simulated military operational positions under relevant loading conditions on global and local lumbar spine postures in active duty male US Marines. Secondary objectives were to evaluate if intervertebral disc degeneration and low back pain affect lumbar spine postures. Magnetic resonance images were acquired on an upright scanner in the following operational positions: Natural standing with no external load, standing with body armor (11.3 kg), sitting with body armor, and prone on elbows with body armor. Custom software was used to measure global lumbar spine posture: Lumbosacral flexion, sacral slope, lordosis, local measures of intervertebral angles, and intervertebral distances. Sitting resulted in decreased lumbar lordosis at all levels of the spine except L1–L2. When subjects were prone on elbows, a significant increase in local lordosis was observed only at L5–S1 compared with all other positions. Marines with disc degeneration (77%) or history of low back pain (72%) had decreased lumbar range of motion and less lumbar extension than healthy Marines. These results indicate that a male Marine's pathology undergoes a stereotypic set of postural changes during functional tasks, which may impair performance. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2145–2153, 2017.
Positive outcomes following gait therapy intervention for hip osteoarthritis: A longitudinal study
Authors: Solomonow‐Avnon Deborah , Herman Amir , Levin Daniel , Rozen Nimrod , Peled Eli , Wolf Alon 
Published: January 2017

ABSTRACTFootwear‐generated biomechanical manipulation of lower‐limb joints was shown to beneficially impact gait and quality of life in knee osteoarthritis patients, but has not been tested in hip osteoarthritis patients. We examined a customized gait treatment program using a biomechanical device shown in previous investigations to be capable of manipulating hip biomechanics via foot center of pressure (COP) modulation. The objective of this study was to assess the treatment program for hip osteoarthritis patients, enrolled in a 1‐year prospective investigation, by means of objective gait and spatiotemporal parameters, and subjective quality of life measures. Gait analysis and completion of questionnaires were performed at the start of the treatment (baseline), and after 3, 6, and 12 months. Outcome parameters were evaluated over time using linear mixed effects models, and association between improvement in quality of life measures and change in objective outcomes was tested using mixed effect linear regression models. Quality of life measures improved compared to baseline, accompanied by increased gait speed and cadence. Sagittal‐plane hip joint kinetics, kinematics, and spatiotemporal parameters changed throughout the study compared to baseline, in a manner suggesting improvement of gait. The most substantial improvement occurred within 3 months after treatment initiation, after which improvement approximately plateaued, but was sustained at 12 months. Speed and cadence, as well as several sagittal‐plane gait parameters, were significant predictors of improvement in quality of life. Clinical significance: Evidence suggests that a biomechanical gait therapy program improves subjective and objective outcomes measures and is a valid treatment option for hip osteoarthritis. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2222–2232, 2017.
Transoral submandibulotomy for deep hilar submandibular gland sialolithiasis
Authors: Schapher Mirco , Mantsopoulos Konstantinos , Messbacher Maria‐Elena , Iro Heinrich , Koch Michael 
Published: January 2017

Objectives/HypothesisTo assess the long‐term results after transoral submandibulotomy for stones located in the deep hilar and intraparenchymal submandibular region.Study DesignRetrospective cohort analysis.MethodsRetrospective evaluation including all patients treated with transoral submandibulotomy for sialolithiasis at a tertiary referral center.ResultsComplete stone removal at the first transoral surgical treatment was achieved in 185 of 234 patients (79.1%). One hundred seventy‐five of the 234 patients were followed up for a mean of 31.2 ( ± 20.5) months. During the follow‐up period, 140 of the 175 patients (80.0%) became symptom free after one operation. In patients with residual symptoms, no further treatment was needed in 12 patients (6.9%) due to the mildness of the symptoms; 23 patients (13.1%) received further therapy, which was successful in 15 cases. Submandibulectomy only had to be performed in 3.4% of the patients with follow‐up (6/175). In a questionnaire survey, 91.4% of the patients stated that they would be prepared to have the same operation again.ConclusionsThese findings show that transoral removal of submandibular sialoliths located in the deep hilum or adjacent intraglandular parenchyma is an effective treatment that can be assisted by additional measures. The techniques described show high success rates, good long‐term results, low complication rates, and they avoided the need for submandibulectomy in >95% of cases.Level of Evidence4. Laryngoscope, 127:2038–2044, 2017
Objectively estimating the temporal evolution of accuracy and skill in a global ocean reanalysis
Authors: Storto Andrea , Masina Simona 
Published: January 2017

ABSTRACTThe accuracy of ocean reanalyses is acknowledged to have increased dramatically during the last few decades, as a consequence of the evolution of the oceanic and atmospheric observing networks. Because of evolution of the atmospheric observing system, a similar accuracy increase also occurs in assimilation‐free global ocean simulations. However, the temporal evolution of traditional accuracy metrics based on comparing reanalyses with observations is affected by the change in the number and spatial sampling of the verifying observations themselves. To disentangle the accuracy evolution and the changes in the verifying dataset, procedures insensitive to the latter are recommended. A simple and easy‐to‐implement methodology inspired by bootstrapping is proposed, specifically conceived for objectively estimating the accuracy and skill evolution of reanalyses over long (e.g. inter‐decadal) periods. This allows the artificial impact of the observational network evolution on the verification metrics, which generally led to under‐estimated accuracy at the beginning of the reanalysis period and much too sharp an increase later, to be overcome. Applied to the assessment of ocean temperature accuracy and skill in a state‐of‐the‐art eddy‐permitting global ocean reanalysis covering the period 1982–2012, the methodology illuminates the crucial impact on the upper ocean (top 100 m) reanalysis skill of both the atmospheric and oceanic observing network evolution, the former leading to a quicker skill increase. Conversely, the fundamental effect of the oceanic observing network below 100 m emerges from the study, as the assimilation‐free simulation shows no skill at any time in the comparison against observations.
Finite time control of robotic manipulators with position output feedback
Authors: Abooee Ali , Moravej Khorasani Masoud , Haeri Mohammad 
Published: January 2017

SummaryThis paper deals with the robust finite time tracking of desired trajectories for a wide group of robotic manipulators in spite of unknown disturbances, uncertainties, and saturations of actuators while only manipulator's positions are available and its velocities are not measurable physically. A new form of chattering‐free second order fast nonsingular terminal sliding mode control scheme is introduced to design input torques for fulfilling the determined tracking objective in the adjustable total finite settling time. The proposed control algorithm is incorporated with two nonlinear observers to estimate disturbances and velocities of joints within finite settling times. The global finite time stability of the closed‐loop manipulator is analytically proved. Finally, a numerical simulation is carried out to verify the effectiveness of the designed input torques. Copyright © 2017 John Wiley & Sons, Ltd.
Is 2D speckle tracking echocardiography useful for detecting and monitoring myocardial dysfunction in adult m.3243A>G carriers? — a retrospective pilot study
Authors: Koene S. , Timmermans J. , Weijers G. , de Laat P. , de Korte C. L. , Smeitink J. A. M. , Janssen M. C. H. , Kapusta L. 
Published: January 2017

AbstractObjectivesCardiomyopathy is a common complication of mitochondrial disorders, associated with increased mortality. Two dimensional speckle tracking echocardiography (2DSTE) can be used to quantify myocardial deformation. Here, we aimed to determine the usefulness of 2DSTE in detecting and monitoring subtle changes in myocardial dysfunction in carriers of the 3243A>G mutation in mitochondrial DNA.MethodsIn this retrospective pilot study, 30 symptomatic and asymptomatic carriers of the mitochondrial 3243A>G mutation of whom two subsequent echocardiograms were available were included. We measured longitudinal, circumferential and radial strain using 2DSTE. Results were compared to published reference values.ResultsSpeckle tracking was feasible in 90 % of the patients for longitudinal strain. Circumferential and radial strain showed low face validity (low number of images with sufficient quality; suboptimal tracking) and were therefore rejected for further analysis. Global longitudinal strain showed good face validity, and was abnormal in 56–70 % (depending on reference values used) of the carriers (n = 27). Reproducibility was good (mean difference of 0.83 for inter‐ and 0.40 for intra‐rater reproducibility; ICC 0.78 and 0.89, respectively). The difference between the first and the second measurement exceeded the measurement variance in 39 % of the cases (n = 23; feasibility of follow‐up 77 %).DiscussionEven in data collected as part of clinical care, two‐dimensional strain echocardiography seems a feasible method to detect and monitor subtle changes in longitudinal myocardial deformation in adult carriers of the mitochondrial 3243A>G mutation. Based on our data and the reported accuracy of global longitudinal strain in other studies, we suggest the use of global longitudinal strain in a prospective follow‐up or intervention study.
Mortality after hematopoietic stem cell transplantation for severe mucopolysaccharidosis type I: the 30‐year University of Minnesota experience
Authors: Rodgers Nathan J. , Kaizer Alexander M. , Miller Weston P. , Rudser Kyle D. , Orchard Paul J. , Braunlin Elizabeth A. 
Published: January 2017

AbstractBackground and aimMucopolysaccharidosis IH (MPS IH, Hurler syndrome) naturally leads to death within the first decade of life, primarily from cardiac and pulmonary causes. To determine how hematopoietic stem cell transplantation (HSCT) has altered mortality, we analyzed our institution's 30‐year experience of patients with MPS IH undergoing HSCT.MethodsUsing chart review and the National Death Index, we determined survival status of 134 patients (males = 69) with MPS IH transplanted between 9/16/1983 and 7/25/2013 on 12/31/2013. Analysis included descriptive statistics, Kaplan‐Meier curves, and regression analysis by Cox proportional hazards model.ResultsOverall survival (95% CI) at one‐ and 25‐years was 70% (62–78%) and 37% (19–55%), respectively. From 2004 onward, overall survival at one‐ and 8‐years was 84% (73–96%) and 81% (69–94%), respectively, compared to 65% (55–74%) and 57% (47–67%) prior to 2004 (Log‐rank p = 0.032). Regardless of era, male survival was significantly better than female (HR 0.40, [95% CI: 0.21–0.74], p = 0.004). The cumulative incidence of death (95% CI) at 25 years was 63% (45–81%); incidence of pulmonary‐related death was the highest at 27% (10–41%) compared to 8% (0.3–16%) for cardiac, 12% (6–17%) for infectious disease, and 16% (3–27%) from other complications.ConclusionsHSCT has increased survival in MPS IH beyond the third decade of life and decreased the incidence of cardiac mortality, but deaths after the third year post‐HSCT occur in excess of expected US mortality. It is important to determine if improved transplant strategies since 2004 result in better long‐term survival in the current patient population.
Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist
Authors: So Mariko , Hashimoto Hirofumi , Saito Reiko , Yamamoto Yukiyo , Motojima Yasuhito , Ueno Hiromichi , Sonoda Satomi , Yoshimura Mitsuhiro , Maruyama Takashi , Kusuhara Koichi , Ueta Yoichi 
Published: January 2017

Abstract
Orexin-A and -B, and ghrelin are potent orexigenic peptides. The effects of ACT462206, a novel dual orexin receptor antagonist (DORA), on ghrelin-induced feeding were examined in adult male Wistar rats. Hyperphagia induced by the intracerebroventricular (icv) administration of ghrelin was significantly suppressed for at least 2 h by pretreatment with icv administration of DORA. A marked increase was observed in the number of neurons showing Fos immunoreactivity in the paraventricular nucleus, arcuate nucleus and lateral hypothalamic area (LHA), 90 min after icv administration of ghrelin. Pretreatment with DORA significantly decreased the number of Fos-immunoreactive (IR) neurons; however, Fos immunoreactivity remained significantly increased. Double-immunostaining for Fos and orexin-A showed that many orexin-A-IR neurons in the LHA coexisted with Fos immunoreactivity after icv administration of ghrelin, but their number was reduced significantly by DORA pretreatment. These results suggest that centrally administered ghrelin may activate the orexinergic and non-orexinergic pathways responsible for the regulation of feeding.
Age at Arrival and Life Chances Among Childhood Immigrants
Authors: Hermansen Are Skeie 
Published: January 2017

AbstractThis study examines the causal relationship between childhood immigrants’ age at arrival and their life chances as adults. I analyze panel data on siblings from Norwegian administrative registries, which enables me to disentangle the effect of age at arrival on adult socioeconomic outcomes from all fixed family-level conditions and endowments shared by siblings. Results from sibling fixed-effects models reveal a progressively stronger adverse influence of immigration at later stages of childhood on completed education, employment, adult earnings, occupational attainment, and social welfare assistance. The persistence of these relationships within families indicates that experiences related to the timing of childhood immigration have causal effects on later-life outcomes. These age-at-arrival effects are considerably stronger among children who arrive from geographically distant and economically less-developed origin regions than among children originating from developed countries. The age-at-arrival effects vary less by parental education and child gender. On the whole, the findings indicate that childhood immigration after an early-life formative period tends to constrain later human capital formation and economic opportunities over the life course.