bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pavel Tchelitchew and Jean Giraudoux’s Ondine
Authors: Kovalenko Georgy 
Published: October 2017

Abstract
The article treats of the artistic collaboration between writer Jean Giraudoux, actor Louis Jouvet and painter Pavel Tchelitchew (Chelishchev) in Paris in the 1930s. While reference is also made to precedents such as Christian Bérard’s interpretations at the Théâtre de l’Athénée, the main subject of discussion is the production of Giraudoux’s Ondine in 1939 with Madelaine Ozeray in the lead role and with Tchelitchew’s eccentric stage sets, backdrops and lighting—and costumes for dramatis personae Ondine, Bertha and Hans. Also discussed are the connections between these designs and Tchelitchew’s major studio paintings such as Hide and Seek.
Temporal Variability of the Charlotte (Sub)Urban Heat Island
Authors: Eastin Matthew D. , Baber Matthew , Boucher Adrienne , Di Bari Sofia , Hubler Ryan , Stimac-Spalding Brandy , Winesett Thomas 
Published: October 2017

AbstractA multiscale temporal analysis of the urban heat island (UHI) for a large, rapidly growing, subtropical city (Charlotte, North Carolina) is conducted using hourly surface observations from a regional network of 12 weather and air-quality stations over a 5-yr period and monthly mean surface temperatures from two stations over a 40-yr period. Each station was classified as urban, suburban, or rural after detailed site analysis. During the 5-yr period, from temperature differences between the most central urban site and the rural reference site, over 70% of nights exhibited prominent nocturnal UHIs. The most intense UHIs occurred on winter nights with light winds, clear skies, low humidity, strong low-level stability, and no precipitation or frontal passage. The UHI maxima occurred either just after sunset or near sunrise. Maximum urban and rural cooling rates occurred within a few hours of sunset, but rural maxima were larger and preceded (by 1–2 h) the urban maxima. Daily variations in nocturnal mean UHI intensity exhibited significant positive correlations with cloud-base height, atmospheric stability, NO2 concentration, and total solar radiation and significant negative correlations with relative humidity, wind speed, and cloud cover. When optimal weather for UHI development was present, UHIs were more intense on weekdays than on weekends. During the 40-yr period, an appreciable positive trend in UHI intensity occurred. These results support the notion that weather, air pollution, and urban form change can significantly modulate UHI intensities. Similarities and differences between the Charlotte UHI and those observed in similar cities are discussed.
Global Assessment of the SMAP Level-4 Surface and Root-Zone Soil Moisture Product Using Assimilation Diagnostics
Authors: Reichle Rolf H. , De Lannoy Gabrielle J. M. , Liu Qing , Koster Randal D. , Kimball John S. , Crow Wade T. , Ardizzone Joseph V. , Chakraborty Purnendu , Collins Douglas W. , Conaty Austin L. , Girotto Manuela , Jones Lucas A. , Kolassa Jana , Lievens Hans , Lucchesi Robert A. , Smith Edmond B. 
Published: October 2017

Abstract
The Soil Moisture Active Passive (SMAP) mission Level-4 Soil Moisture (L4_SM) product provides 3-hourly, 9-km resolution, global estimates of surface (0–5 cm) and root-zone (0–100 cm) soil moisture and related land surface variables from 31 March 2015 to present with ~2.5-day latency. The ensemble-based L4_SM algorithm assimilates SMAP brightness temperature (Tb) observations into the Catchment land surface model. This study describes the spatially distributed L4_SM analysis and assesses the observation-minus-forecast (O − F) Tb residuals and the soil moisture and temperature analysis increments. Owing to the climatological rescaling of the Tb observations prior to assimilation, the analysis is essentially unbiased, with global mean values of ~0.37 K for the O − F Tb residuals and practically zero for the soil moisture and temperature increments. There are, however, modest regional (absolute) biases in the O − F residuals (under ~3 K), the soil moisture increments (under ~0.01 m3 m−3), and the surface soil temperature increments (under ~1 K). Typical instantaneous values are ~6 K for O − F residuals, ~0.01 (~0.003) m3 m−3 for surface (root zone) soil moisture increments, and ~0.6 K for surface soil temperature increments. The O − F diagnostics indicate that the actual errors in the system are overestimated in deserts and densely vegetated regions and underestimated in agricultural regions and transition zones between dry and wet climates. The O − F autocorrelations suggest that the SMAP observations are used efficiently in western North America, the Sahel, and Australia, but not in many forested regions and the high northern latitudes. A case study in Australia demonstrates that assimilating SMAP observations successfully corrects short-term errors in the L4_SM rainfall forcing.
A Miniature Acoustic Device for Tracking Small Marine Animals or Submerged Drifters
Authors: Fischer G. , Rossby T. , Moonan D. 
Published: October 2017

AbstractThis paper presents an acoustic archival tag capable of tracking small marine animals. It is also a technology that can be ported to other platforms, such as the next-generation acoustic and Argo floats as well as gliders. Tracking is achieved by standard RAFOS triangulation using the arrival times of unique sound signals emitted by moored sources. At the core of the tag is a custom microchip that controls all system operations. It incorporates the critical acoustic arrival time detector, a thermal sensor, and a pressure sensor interface. All the electronic components are housed inside a cylindrical hydrophone of 25.4-mm length and 10.7-mm diameter. The collected data are archived in nonvolatile memory chips with a total capacity of 4 Mb, sufficient storage to record position, temperature, and pressure on an hourly basis for 2 years. The tag consumes 4–5 μW in standby mode and between 60 and 90 μW while the sound arrival time detector is in operation. The power is provided by two button cell silver-oxide batteries, which enable an active tag lifetime of approximately 2 years.
Predictors of Clinicopathologic Stage Discrepancy in Oropharyngeal Squamous Cell Carcinoma: A National Cancer Database Study
Authors: Kılıç Suat , Kılıç Sarah S. , Shah Kajal P. , Eloy Jean Anderson , Baredes Soly , Mahmoud Omar M. , Park Richard Chan Woo 
Published: October 2017

ObjectiveTo determine the frequency, associated factors, and prognosis of clinicopathologic stage discrepancy in oropharyngeal squamous cell carcinoma (OPSCC).Study DesignRetrospective study using a national database.SettingNational Cancer Database.Subjects and MethodsCases of OPSCC diagnosed between January 1, 2004, and December 31, 2013, with full clinical and pathologic staging information available were identified. Demographic, clinicopathologic, and treatment variables associated with overall stage discrepancy were identified by multivariate logistic regression analysis.ResultsIn total, 7731 cases of OPSCC were identified. Overall stage discrepancy was present in 30.2% of cases (21.9% upstaging, 8.2% downstaging). A total of 13.1% of cases were T‐upstaged, and 10.5% of cases were T‐downstaged; 22.9% of cases were N‐upstaged, and 8.6% of cases were N‐downstaged. Upstaging by overall stage was associated with a high Charlson‐Deyo score, high tumor grade, number of lymph nodes examined, and increasing tumor size. No factors were positively associated with downstaging. High tumor grade was negatively associated with downstaging. For stage II, III, and IVA tumors, upstaging was associated with poorer OS.ConclusionClinicopathologic stage discrepancy is common in OPSCC and is likely attributable to insensitive clinical staging techniques as well as to intrinsic tumor biologic properties. Upstaging is associated with poorer prognosis, which is likely due to advancement of disease.
Periostin as a Biomarker for Nasal Polyps in Chronic Rhinosinusitis
Authors: Maxfield Alice Z. , Landegger Lukas D. , Brook Christopher D. , Lehmann Ashton E. , Campbell Adam P. , Bergmark Regan W. , Stankovic Konstantina M. , Metson Ralph 
Published: October 2017

ObjectivePeriostin is an extracellular matrix protein that is elevated in the sinonasal tissues of patients with chronic rhinosinusitis (CRS). The purpose of this study was to determine whether serum periostin could serve as a molecular biomarker of nasal polyp burden in sinonasal disease.Study DesignProspective cohort study.SettingAcademic medical center.Subjects and MethodsSerum periostin levels were measured by ELISA on blood samples collected from patients undergoing sinus surgery for CRS (n = 71), further stratified by phenotype as defined by nasal polyps and asthma. Results were compared with assays performed on control subjects (n = 62).ResultsMean serum periostin levels were markedly elevated in patients with CRS versus controls (66.1 ng/mL [95% CI, 51.6‐80.6] vs 38.7 ng/mL [95% CI, 34.4‐42.9], respectively, P =. 004). In addition, mean periostin levels were significantly higher in CRS patients with nasal polyps as compared with those without polyps (94.8 ng/mL [95% CI, 67.3‐122.4] vs 41.1 ng/mL [95% CI, 35.2‐47.0], respectively, P <. 001). Periostin levels did not correlate with sex (P =. 473), smoking history (P =. 748), aspirin‐exacerbated respiratory disease status (P =. 136), oral steroid use within 1 month of surgery (P =. 281), use of topical steroid nasal spray (P =. 864), or number of prior sinus operations (P =. 973).ConclusionSerum periostin appears to be a novel molecular biomarker for the presence of nasal polyps and may serve as an indicator of CRS endotypes.
Use of beta-blockers and risk of serious upper gastrointestinal bleeding: a population-based case-control study
Authors: Reilev Mette , Damkier Per , Rasmussen Lotte , Olesen Morten , Thomsen Ernst Martin , Rishøj Rikke Mie , Rix Hansen Morten , Broe Anne , Dastrup Alexander Steenberg , Hellfritzsch Maja , Arnspang Sidsel , Pottegård Anton , Hallas Jesper 
Published: October 2017

Background: Some studies indicate a reduced risk of serious upper gastrointestinal bleeding (UGIB) for users of beta-blockers, but the association remains to be confirmed in larger studies and characterized with respect to differences among beta-blockers. We aimed to assess whether beta-blocker use decreases the risk of UGIB. Methods: We conducted a register-based, population-based case-control study in Denmark. We identified cases with a first validated discharge diagnosis of UGIB during the period 1995–2006. Controls were selected by risk-set sampling in a ratio of 10:1. We estimated crude and adjusted odds ratios (ORs) of the association between current beta-blocker use and the risk of UGIB by using conditional logistic regression and further stratified by selective and non-selective beta-blockers, respectively. Results: We identified 3571 UGIB cases and 35,582 controls. Use of beta-blockers was not found to be associated with a decreased risk of UGIB (adjusted OR 1.10; 95% CI: 1.00–1.21). The association remained neutral after stratification by selective and non-selective beta-blockers, and by single beta-blocker substances. Similarly, we found no association between current beta-blocker use and the risk of UGIB within different subgroups. Conclusions: We found no association between beta-blocker use and UGIB.
Stochastic Seasonal Models for Glucose Prediction in the Artificial Pancreas
Authors: Montaser Eslam , Díez José-Luis , Bondia Jorge 
Published: October 2017

Background:Linear empirical dynamic models have been widely used for glucose prediction. The extension of the concept of seasonality, characteristic of other domains, is explored here for the improvement of prediction accuracy.Methods:Twenty time series of 8-hour postprandial periods (PP) for a same 60g-carbohydrate meal were collected from a closed-loop controller validation study. A single concatenated time series was produced representing a collection of data from similar scenarios, resulting in seasonality. Variability in the resulting time series was representative of worst-case intrasubject variability. Following a leave-one-out cross-validation, seasonal and nonseasonal autoregressive integrated moving average models (SARIMA and ARIMA) were built to analyze the effect of seasonality in the model prediction accuracy. Further improvement achieved from the inclusion of insulin infusion rate as exogenous variable was also analyzed. Prediction horizons (PHs) from 30 to 300 min were considered.Results:SARIMA outperformed ARIMA revealing a significant role of seasonality. For a 5-h PH, average MAPE was reduced in 26.62%. Considering individual runs, the improvement ranged from 6.3% to 54.52%. In the best-performing case this reduction amounted to 29.45%. The benefit of seasonality was consistent among different PHs, although lower PHs benefited more, with MAPE reduction over 50% for PHs of 60 and 120 minutes, and over 40% for 180 min. Consideration of insulin infusion rate into the seasonal model further improved performance, with a 61.89% reduction in MAPE for 30-min PH and reductions over 20% for PHs over 180 min.Conclusions:Seasonality improved model accuracy allowing for the extension of the PH significantly.
Assessment of HPV screening methods and sample storage in oral lichen planus lesions
Authors: Poulopoulos Athanasios , Hempel Mattias , Karakitsos George , Fakis Apostolos , Andreadis Dimitrios 
Published: October 2017

Aim: We investigated the human papillomavirus (HPV) DNA distribution in oral lichen planus (OLP) samples using non-invasive methods, with the potential for much broader population screening. Methods: Three different non-invasive collection methods (dry storage, lysis buffer preservation, and use of a commercial tool to rake epithelial cells and immersion of the collection device into the provided rinse solution) were evaluated. HPV DNA was detected in brushed or scraped samples of the lesion site using a commercial HPV DNA polymerase chain reaction kit. Results: In the group of patients with OLP lesions, HPV was detected significantly more frequently than in the healthy control group (lysis buffer for control = 2.1%, p = 0.046; DNA•SAL™ rinse solution for control = 4.2%, p = 0.0003; dry storage for control = 6.3%, p = 0.0001) regardless of the different collection and preservation methods. HPV DNA was detected in 12.85% of the samples preserved in lysis buffer. HPV DNA was detected in 34.28% ( p = 0.0048 vs. lysis buffer) of samples preserved in the DNA•SAL rinse solution. In the case of dry storage, HPV DNA was detected in 38.57% ( p = 0.0008 vs. lysis buffer and p = 0.726 vs. DNA•SAL) of samples. Conclusion: The results suggest that the most effective sample preservation methods are provided by dry storage or DNA•SAL collection compared to lysis buffer. Our findings indicated that HPV DNA detection in superficial OLP scrapings has potential as a screening tool and has important applications for both research and clinical practice.
MRI texture features may predict differentiation and nodal stage of cervical cancer: a pilot study
Authors: Becker Anton S , Ghafoor Soleen , Marcon Magda , Perucho Jose A , Wurnig Moritz C , Wagner Matthias W , Khong Pek-Lan , Lee Elaine YP , Boss Andreas 
Published: October 2017

Background Texture analysis in oncological magnetic resonance imaging (MRI) may yield surrogate markers for tumor differentiation and staging, both of which are important factors in the treatment planning for cervical cancer. Purpose To identify texture features which may predict tumor differentiation and nodal status in diffusion-weighted imaging (DWI) of cervical carcinoma Material and Methods Twenty-three patients were enrolled in this prospective, institutional review board (IRB)-approved study. Pelvic MRI was performed at 3-T including a DWI echo-planar sequence with b-values 40, 300, and 800 s/mm2. Apparent diffusion coefficient (ADC) maps were used for region of interest (ROI)-based texture analysis (32 texture features) of tumor, muscle, and fat based on histogram and gray-level matrices (GLM). All features confounded by the ROI size (linear model) were excluded. The remaining features were examined for correlations with histological differentiation (Spearman) and nodal status (Kruskal–Wallis). Hierarchical cluster analysis was used to identify correlations between features. A P value < 0.05 was considered statistically significant. Results Mean age was 55 years (range = 37–78 years). Biopsy revealed two well-differentiated, eight moderately differentiated, two moderately to poorly differentiated tumors, and five poorly differentiated tumors. Six tumors could not be graded. Lymph nodes were involved in 11 patients. Three GLM features correlated with the differentiation: LRHGE (ϱ = 0.53, P = 0.03), ZP (ϱ = –0.49, P < 0.05), and SZE (ϱ = –0.51, P = 0.04). Two histogram features, skewness (0.65 vs. 1.08, P = 0.04) and kurtosis (0.53 vs. 1.67, P = 0.02), were higher in patients with positive nodal status. Cluster analysis revealed several co-correlations. Conclusion We identified potentially predictive GLM features for histological tumor differentiation and histogram features for nodal cancer stage.
Nivolumab Plus Ipilimumab in Patients With Advanced Melanoma: Updated Survival, Response, and Safety Data in a Phase I Dose-Escalation Study
Authors: Callahan Margaret K. , Kluger Harriet , Postow Michael A. , Segal Neil H. , Lesokhin Alexander , Atkins Michael B. , Kirkwood John M. , Krishnan Suba , Bhore Rafia , Horak Christine , Wolchok Jedd D. , Sznol Mario 
Published: October 2017

Purpose The clinical activity observed in a phase I dose-escalation study of concurrent therapy with nivolumab (NIVO) and ipilimumab (IPI) in patients with previously treated or untreated advanced melanoma led to subsequent clinical development, including randomized trials. Here, we report long-term follow-up data from study CA209-004, including 3-year overall survival (OS). Patients and Methods Concurrent cohorts 1, 2, 2a, and 3 received escalating doses of NIVO plus IPI once every 3 weeks for four doses, followed by NIVO once every 3 weeks for four doses, then NIVO plus IPI once every 12 weeks for eight doses. An expansion cohort (cohort 8) received concurrent NIVO 1 mg/kg plus IPI 3 mg/kg once every 3 weeks for four doses, followed by NIVO 3 mg/kg once every 2 weeks, which is the dose and schedule used in phase II and III studies and now approved for patients with unresectable or metastatic melanoma. Results Among all concurrent cohorts (N = 94) at a follow-up of 30.3 to 55.0 months, the 3-year OS rate was 63% and median OS had not been reached. Objective response rate by modified WHO criteria was 42%, and median duration of response was 22.3 months. Incidence of grade 3 and 4 treatment-related adverse events was 59%. The most common grade 3 and 4 treatment-related adverse events were increases in lipase (15%), alanine aminotransferase (12%), and aspartate aminotransferase (11%). One treatment-related death (1.1%) occurred in a patient who had multiorgan failure 70 days after the last dose of NIVO plus IPI. Conclusion This is the longest follow-up for NIVO plus IPI combination therapy in patients with advanced melanoma. The 3-year OS rate of 63% is the highest observed for this patient population and provides additional evidence for the durable clinical activity of immune checkpoint inhibitors in the treatment of advanced melanoma.
“Boys Over Here, Girls Over There”
Authors: Woolley Susan W. 
Published: October 2017

AbstractIn K–12 schools, practices of dividing students by biological sex or gender into binary categories limit possibilities for students' identification and representation. Dividing students according to their socially recognized sex or gender reinforces the perceived stability of binary male/female sex and binary masculine/feminine gender categories while also exceptionalizing transgender identities. Students and teachers who challenge such practices engage in critical literacy readings of school spaces and of the mundane ways binary gender and sex are read onto bodies. Critical literacy provides a method through which students and teachers may engage in reflection and critical practice to raise awareness and challenge everyday practices in schools that construct boys and girls as stable, discrete categories. Drawing on three years of ethnographic research in an urban public high school, this article examines the ways teachers and students enact, respond to, and subvert practices that articulate and distinguish categories of boys and girls.
Pedagogies of Becoming
Authors: Malatino Hilary 
Published: October 2017

Abstract
Conventional approaches to trans inclusion in the women's, gender, and sexuality studies classroom often involve what Diana Courvant has called the “special guest” approach of bringing in trans, intersex, and gender-nonconforming folk to represent and authenticate trans experiences, perspectives, and political engagements. This essay argues for the inadequacy of this pedagogical strategy, focusing on its complicity with a neoliberal politics of inclusion that fails to move students to deal with their own deep complicities in upholding understandings of sex and gender that are fundamentally transphobic, as well as its failure prompt pragmatic understanding and address of the maldistribution of life chances for trans, intersex, and gender-nonconforming subjects. I offer several alternative strategies aimed at producing more deeply transformative types of trans inclusion in WGSS classrooms. These strategies focus on mapping connections between cis and trans experiences of gendered transformation in order to produce an alternative understanding of gender as process, craft, and becoming.
“Trans Enough?”
Authors: Catalano D. Chase J. 
Published: October 2017

Abstract
Despite increasing attention on issues raised by trans students in higher education, almost no empirical research has examined the identities and experiences of trans students as a group, or of specific subsets of trans students. In this article, I draw on interviews with twenty-five trans-male undergraduate students to explore how their experiences of coming to understand their gender identities are shaped by their experiences in higher education. I show how participants' concerns about being “trans enough” highlight contradictions within identity discourses of and about trans men, and how their narratives often rely on a medical model or “wrong body” discourse, even while students critique that model. Participants described expending significant energy navigating conflicting demands from other trans men, from other peers, and from their undergraduate institutions, in ways that often overshadowed their own desires and internal senses of identity. Institutions should support further research to explore the experiences and needs of trans men and other trans students, while implementing known best practices to become more trans-inclusive campuses.
Two Trans* Teachers in Madrid
Authors: Platero Raquel (Lucas) , Drager Em Harsin 
Published: October 2017

Abstract
Trans*formative pedagogies are explored through dialogue between two trans* teachers working in Madrid public schools. The queer methodological approach of personal dialogue and reflection provides an inside perspective into the emergent development of trans* pedagogy in public school classrooms. The authors' divergent positionalities raise challenging questions for trans* teachers: How are gender and sexuality still perceived as dangerous topics in education, and how can these issues be addressed with students? Can we move beyond chicos y chicas identity politics? Is the presence of a trans* teacher in the classroom enough to create transformative pedagogy? How does this work connect to, uphold, and challenge the neoliberal economic paradigms that shape public education? The specificity of the Spanish educational context is emphasized, with attention to the complexities of bilingual education and cultural imperialism.