bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHANGES IN THE HIP IN YOUTH HOCKEY PLAYERS OVER 5 SEASONS
Authors: Briggs Karen , Philippon Marc , McNamara Shannen , Ho Charles 
Published: April 2017

BackgroundIt has been reported that relative to other sports participants, ice hockey players suffer from cam femoroacetabular impingement (FAI) in higher numbers. Alpha angles have been reported to increase with the likelihood of symptomatic FAI. It is unclear how alpha angle and other factors related to FAI change over early childhood years.ObjectiveTrack youth hockey players over 5 years and determine if factors associated with FAI increased as they aged and increased skating time.DesignScreening.SettingYouth club.Patients (or Participants)16 asymptomatic youth ice hockey players. All players started in the peewee(ages 10 to 12) division and moved up in divisions over the 3 years.Interventions (or Assessment of Risk Factors)Clinical hip examination consisting of the FABER test, impingement testing, and measurement of hip internal rotation. An MRI was taken and the hip alpha angle was measured and labral tears were documented.Main Outcome MeasurementsAlpha angle and labral tear on MRIResultsThese youth hockey players played an average of 42 weeks/year Players had significantly increased alpha angle by year 3 of screening. The average alpha angle at year 1 was 56(range 45 to 63), year 2 was 59 (range 52 to 68), year 3 was 75 (range 64 to 88), year 4 was 75 and year 5 was 78. By year 5, 14/16 had asymptomatic labral tears. There were no significant changes in internal rotation over the 5 years. There was a trend toward decreased internal rotation in goalies.ConclusionsYoung ice hockey players show increasing alpha angles and development of asymptomatic labral tears. Stresses inherent to ice hockey likely enhance the development of a bony overgrowth on the femoral neck contributing to cam FAI.
Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma
Authors: Sagawa Morihiko , Ohguchi Hiroto , Harada Takeshi , Samur Mehmet K. , Tai Yu-Tzu , Munshi Nikhil C. , Kizaki Masahiro , Hideshima Teru , Anderson Kenneth C. 
Published: April 2017

Abstract
Purpose: To investigate the biological and clinical significance of ribonucleotide reductase (RR) in multiple myeloma.
Experimental Design: We assessed the impact of RR expression on patient outcome in multiple myeloma. We then characterized the effect of genetic and pharmacologic inhibition of ribonucleotide reductase catalytic subunit M1 (RRM1) on multiple myeloma growth and survival using siRNA and clofarabine, respectively, in both in vitro and in vivo mouse xenograft models.
Results: Newly diagnosed multiple myeloma patients with higher RRM1 expression have shortened survival. Knockdown of RRM1 triggered significant growth inhibition and apoptosis in multiple myeloma cells, even in the context of the bone marrow microenvironment. Gene expression profiling showed upregulation of DNA damage response genes and p53-regulated genes after RRM1 knockdown. Immunoblot and qRT-PCR analysis confirmed that γ-H2A.X, ATM, ATR, Chk1, Chk2, RAD51, 53BP1, BRCA1, and BRCA2 were upregulated/activated. Moreover, immunoblots showed that p53, p21, Noxa, and Puma were activated in p53 wild-type multiple myeloma cells. Clofarabine, a purine nucleoside analogue that inhibits RRM1, induced growth arrest and apoptosis in p53 wild-type cell lines. Although clofarabine did not induce cell death in p53-mutant cells, it did trigger synergistic toxicity in combination with DNA-damaging agent melphalan. Finally, we demonstrated that tumor growth of RRM1-knockdown multiple myeloma cells was significantly reduced in a murine human multiple myeloma cell xenograft model.
Conclusions: Our results therefore demonstrate that RRM1 is a novel therapeutic target in multiple myeloma in the preclinical setting and provide the basis for clinical evaluation of RRM1 inhibitor, alone or in combination with DNA-damaging agents, to improve patient outcome in multiple myeloma. Clin Cancer Res; 23(17); 5225–37. ©2017 AACR.
Genome-Wide Association Studies of Chemotherapeutic Toxicities: Genomics of Inequality
Authors: Mapes Brandon , El Charif Omar , Al-Sawwaf Shereen , Dolan M. Eileen 
Published: April 2017

Abstract
With an estimated global population of cancer survivors exceeding 32 million and growing, there is a heightened awareness of the long-term toxicities resulting from cancer treatments and their impact on quality of life. Unexplained heterogeneity in the persistence and development of toxicities, as well as an incomplete understanding of their mechanisms, have generated a growing need for the identification of predictive pharmacogenomic markers. Early studies addressing this need used a candidate gene approach; however, over the last decade, unbiased and comprehensive genome-wide association studies (GWAS) have provided markers of phenotypic risk and potential targets to explore the mechanistic and regulatory pathways of biological functions associated with chemotherapeutic toxicity. In this review, we provide the current status of GWAS of chemotherapeutic toxicities with an emphasis on examining the ancestral diversity of the representative cohorts within these studies. Persistent calls to incorporate both ancestrally diverse and/or admixed populations into genomic efforts resulted in a recent rise in the number of studies utilizing cohorts of East Asian descent; however, few pharmacogenomic studies to date include cohorts of African, Indigenous American, Southwest Asian, and admixed populations. Through comprehensively evaluating sample size, composition by ancestry, genome-wide significant variants, and population-specific minor allele frequencies as reported by HapMap/dbSNP using NCBI PubMed and the NHGRI-EBI GWAS Catalog, we illustrate how allele frequencies and effect sizes tend to vary among individuals of differing ancestries. In an era of personalized medicine, the lack of diversity in genome-wide studies of anticancer agent toxicity may contribute to the health disparity gap. Clin Cancer Res; 23(15); 4010–9. ©2017 AACR.
<b><i>Xenomerus orientalis</i> Walker (Hymenoptera: Platygastridae): a new distribution record for India</b>
Authors: Managanvi Kalmesh , Karnatak A. K. , Khan M. A. 
Published: April 2017

The genus Xenomerus Walker (Hymenoptera: Platygastridae) consists of 35 described species worldwide, out of which only four species have been reported so far from India. The species X. orientalis Mikó & Masner is reported for the first time in India from Uttarakhand.
<b>New records of social wasps (Hymenoptera: Vespinae: <I>Vespa</I> and <I>Provespa</I>) from Bhutan</b>
Authors: Dorji Phurpa , Gyeltshen Thinley , Klein Wim , Nidup Tshering 
Published: April 2017

A total of eight species and subspecies of the genus Vespa, namely V. velutina nigrithorax du Buysson, 1905, V. basalis Smith, 1852, V. affinis affinis (Linnaeus, 1764), V. affinis indosinensis Pérez, 1910, V. mandarinia magnifica Smith, 1852, V. tropica leefmansi van der Vecht, 1957, V. bicolor Fabricius, 1787, V. analis nigrans du Buysson, 1903 along with Provespa barthelemyi (du Buysson, 1905) is recorded for the first time in Bhutan. The current number of species in the genus Vespa and Provespa found in Bhutan stands at 14. The records for V. mandarinia bellona Smith, 1871 and V. tropica tropica (Linnaeus, 1758) previously reported as from Maria Basti, Bhutan, must be confirmed.
<b>Butterflies associated with major forest types in Arunachal Pradesh (eastern Himalaya), India: implications for ecotourism and conservation planning</b>
Authors: Singh Arun P. 
Published: April 2017

A three year study (from December 2011 to December 2014 and in June 2015) on butterflies covering four major forest sub-types as classified by H.G. Champion & S.K. Seth in 1968 in ‘Forest Types of India’, which occupy 60% of the forest area lying below 2,500m across Arunachal Pradesh State in the eastern Himalaya of India, revealed 415 taxa belonging to six families (Hesperiidae: 74 species of 42 genera; Papilionidae: 37 species of 10 genera; Pieridae: 36 species of 15 genera; Lycaenidae: 85 species of 49 genera; Riodinidae: 7 species of 3 genera & Nymphalidae: 176 species of 71 genera, respectively). These included many endemic and rare species typical of these forest sub-types, i.e., (i) 2B/1S1 Sub-Himalayan Light Alluvial Semi-Evergreen Forest (32 species), (ii) 2B/ C1(a) Assam Alluvial Plains Semi-Evergreen Forests (5 species), (iii) 2B/2S2 Eastern Alluvial Secondary Semi-Evergreen Forests- (15 species) and (iv) 3/1S2 (b) Terminalia-Duabanga (3 species), respectively. The relative number of species and individuals sampled were the highest at altitudes below 500m, and gradually declined as the altitude increased to 2,000m, and above 2,500m species richness declined sharply. The number of species and their relative abundance were the highest during July–August (Monsoon-first peak) and then again in November-December (Autumn-second peak), while the numbers were lowest during winter. These findings suggest that these four forest types are important both for the purpose of ecotourism as well as conservation of endemic and rare taxa found in the eastern Himalaya and northeastern India at altitudes below 2,000m. A complete list of all the taxa sampled is given along with relative abundance status during sampling, Indian Wildlife (Protection) Act, 1972 status, and distribution in different forest types in the state. Ten potential butterfly ecotourism zones are suggested for the state. Planning land-use for biodiversity conservation based on butterfly-forest type associations, by taking forest sub-types as units of conservation, is suggested as an option for the eastern Himalaya.
<b>First record of <I>Neojurtina typica</I> from India (Hemiptera: Heteroptera: Pentatomidae)</b>
Authors: Salini S. 
Published: April 2017

The genus Neojurtina Distant, 1921, represented by the species Neojurtina typica Distant, 1921 (Hemiptera: Pentatomidae: Pentatominae: Pentatomini), is illustrated and redescribed based on the female genitalia. Neojurtina typica is recorded for the first time from India (Meghalaya) and distribution of the species is reviewed based on all the available literature. The present taxonomic placement of the genus Neojurtina is discussed.
<b>Density and obligatory feeding habits of an isolated Golden Jackal <I>Canis aureus</I> L. (Mammalia: Carnivora: Canidae) population in Pirotan Island, Gulf of Kachchh, India</b>
Authors: Ramkumaran Kamaraj , Chandran Rethnaraj , Satyanarayana Chowdula , Chandra Kailash , Shyamal Tikadar 
Published: April 2017

Efforts to arrest the decline of carnivorous mammals in isolated ecosystems have received little attention in India. The present study assesses the population density of a small Golden Jackal population, isolated on a water covered Pirotan Island in the Gulf of Kachchh Marine National Park, India. An average of 12 Golden Jackals/km2 was found inhabiting the Island. The scat analysis revealed that the major diet of jackals was crab (89.5±2.36 %) followed by fish (2.7±0.82 %). Only 2.1% of their diets were from the Island source. They have well adapted to manage their water needs from their obligatory feeding habits.
<b>Distribution and population status assessment of the endemic grass-like palm <I>Butia marmorii</I> (Arecales: Arecaceae) in Paraguay</b>
Authors: Gauto Irene , Palacios Fernando , Marchi Pamela , Silva Nelson , Céspedes Gloria 
Published: April 2017

The palm Butia marmorii Noblick was described in 2006 and has been found to date in only two populations in Paraguay. It is a species threatened mainly due to habitat loss and its ecology is largely unknown. Here we performed a potential distribution analysis, providing data about its distribution and ecology. This work was carried out in the Alto Paraná Department, eastern Paraguay, South America. We analyzed satellite images, in conjunction with a multi-temporal analysis using the sensors Landsat 1-MSS,5-TM,8-OLI, of the years 1973, 1984, 2002, 2012 and 2013; and a posterior visual interpretation of an ASTER ASTGTM2 radar image. The final step was an in situ visual verification. We registered 27 potential sites of distribution for Butia marmorii, finding it present in four sites, two of them with limited anthropogenic impacts. We found a density of 0.0054 to 0.11 individuals/m2, and associations with the congener B. paraguayensis. These new Paraguayan populations of Butia marmorii provide verifiable data demonstrating that anthropogenic impact is the principal threat to the species. Here we found that the situation of B. marmorii is even worse than supposed before, and hence we consider the species to be Critically Endangered.
Abstraction and Schizophrenia
Authors: Hoffer A. , Osmond H. 
Published: April 2017

People can classify objects in at least two different ways. One uses a visual way i.e. a comparison of objects by their appearance such as a pen is like a pencil because they resemble sticks. Another method is to classify objects by their function, thus a pen is like a pencil because they are used for communicating, etc. Other ways of classifying are possible. The hypothesis was tested that schizophrenics tend to use visual classifications when ill. They administered a new card sorting test, the HOD test, to over 500 cases. The results of the experiment corroborated the ‘hypothesis. It was also found that subjects who had unidentified substances in their urine as measured by a specific paper chromatographic technique when compared to subjects who did not have it, also compared objects visually, rather than functionally.
Actualités Psychiatriques Européennes
Authors: Lambert Jules , Plante Normand 
Published: April 2017

As an aftermath to the 60th Congress of French-speaking psychiatrists, held in Antwerp last July, a retrospective of the main subjects studied at those sittings is attempted. New clhemotherapies belonging to the butyrophenone group such as Haloperidol, Haloanisone and Dipiperon raised interesting comments just as Valium and Amitryptilin Hydrochloride (Elavyl) was effective in endogenous depressions. A few personal considerations are made as to the value of psychopharmacology and the importance of an associated psychotherapy. Other papers were centered on the submission and discussion of two main reports. The authors summarize and comment reports one of which, entitled “Psychopathology of Expression” is a review of the various ways of verbal and plastic expression in the mental patient. Semantics of the language in the schizophrenic patient and the existence of a psychopathologic art offer interesting viewpoints. The Second Report of that Congress is both a criticism of occupational guidance tests and an outline of principles basic to the operation of psychomedico-social services. The definition of the test and the analysis of its various components are found in that Report. Finally, papers on conditioning in neuroses, post-puerperal psychoses and modern principles of psychiatric assistance retained the attention of Congress delegates. The rehabilitation of the mental patient is emphasized and the major problems of psychiatric hospitals are the same for our overesas neighbours.
A New Technique to Investigate Family Dynamics in Child Psychiatry (2HT)
Authors: Szyrynski Victor 
Published: April 2017

In assessment of the emotional adjustment of children the psychodynamic relations with the parents, siblings and other significant persons in the environment requires careful attention and often provides the right cue for understanding psychosomatic disorders or the child's reaction to physical illnesses. A very simple test for assessment of family dynamics was developed by the author a few years ago and given intensive trial during the last year. The examiner draws schematically all the members of the child's family and then asks the child to place them in two identical houses, also drawn by the examiner. The child's selection of the family members for “his” house or rejection to the “other” house, the order of such selections, the time necessary for a decision and the child's comments are observed. In the next stage of testing the child is asked to transfer the individuals from the “other” house to “his” and vice versa. The order of selection is again observed. Further modifications of this test were also tried. In many cases it has been found that this comparatively simple procedure enables family dynamics to be revealed through extensive social history and which were otherwise available only through lengthy testing with other projected techniques. The findings on our “two houses test” were also of value in planning for dynamic psychotherapy, play therapy, and otehr treatment procedures.
Utilite D'Un Centre D'Observation Dans un Petit Hopital Psychiatrique
Authors: Gervais Laurent , Bourdon Pierre B. 
Published: April 2017

At the Institut Albert Prévost we have an Observation Ward, which really is an Intensive Care Unit, where we can treat patients who could not be kept in the normal setting of a small psychiatric hospital. This ward is a closed one, and it has a capacity of 16 beds taken up by acute paranoid schizophrenics, suicidal patients, patients in a panic etc. With this ward, the hospital can deal with almost any kind of patient. Be sides the individual therapy there is a good deal of group therapy and occupational therapy which takes place on the premises. The patient is the object of constant care and the staff is also constantly made aware of its reaction to the patient in the daily ward conference and in the weekly ward staff meeting. Finally, some observations are made on group movements on the ward and on the phenomena of socialization.
Article
Authors: Saint-Laurent Claude 
Published: April 2017

The author attempts to draw an outline of psychodermatological problems of adolescence. Starting from the fact that adolescence is the most critical if not the most significant period of the general process of maturation in that it sums up all previous conflicts, he wonders why the skin appears to take such a considerable importance in this regard. In passing, he emphasizes that acne is the only disease related to a phase of psychosexual maturation, which appears to indicate for that phase a specific tropism with regard to the tegumentary covering. The author describes in three separate stages the period of adolescence and attempts to characterize them by their own conflicts. From this point, he indicates the possibilities of establishing some correlation between the type of conflict and the role of the skin in such conflicts. Finally, relying upon the works of Max Shur and Anna Freud, the author does not hesitate in attributing to the skin a vital role in the development of the ego and the libidinal economy of the individual. The author concludes by suggesting that repetition compulsion operates particularly at the level of the skin and that skin lesions constitute a zone of least resistance and invite conflicts to find their expression there. “The erotic quality of certain experiences of itching, scratching, excoriation and exhibition is obvious enough to bring this to our attention.”
Considérations Sur Les Problèmes Et Les Mesures D'Assistance Psychiatrique Et Sociale Aux Personnes Âgées
Authors: La Rue Lucien , Lambert Et Jules 
Published: April 2017

Psychiatric disorders of old age have increased in keeping with increased longevity. Thus, numerous social and economic problems have appeared and require urgent solutions. In the Province of Quebec, there were, in 1961, 43,000 persons aged 65 and over. The insufficient arrangements for assistance in this area should be pointed out. There is no doubt that there should be many more homes and hospitals for aged persons. In addition to extended life expectancy, numerous social and economic factors, such as the conditions of modern living, small dwellings, women working outside their homes, exodus towards cities, evolution of the family group habits, are coming into play. Due to lack of facilities, the mental hospital must admit a large number of aged persons who should be accommodated elsewhere. This constitutes a considerable “overload” of aged persons in psychiatric departments and a slowing down of the rate of care which is prejudicial to patients of a less advanced age who could recover faster. A look at the present situation at St. Michel Archange Hospital and a review of the past ten years, permit the compilation of very revealing statistics. If it is appropriate to set up a geriatric department in a mental hospital it is urgently required, on the other hand, to relieve congestion in the hospital and to build throughout the country regional institutions for aged persons, with all the necessary services and a section for agitated and disabled patients. It is important also to improve existing institutions and take into account previous achievements. Social assistance measures — homes, nursing homes, motels, home care, day centres, sheltered workshops, etc., should retain the attention of the members of the Commission entrusted with the study of those problems by the Psychiatric Hospitals Division in the Ministry of Health.
Studies on the Hyperactive Child I: Some Preliminary Findings
Authors: Werry J. S. , Weiss Gabrielle , Douglas Virginia 
Published: April 2017

In this study of 28 hyperactive children and 28 controls, there is a tendency (P=.09) for more hyperactives than normals to report a history of accidents of pregnancy, delivery and postnatal life which could have caused brain damage. There is no evidence, however, that mothers of hyperactives are predisposed by virtue of such factors as age, parity, abortion rate or general ill health, to produce brain damage in the fœtus. Hyperactives were reported significantly more often than controls to have been hyperirritable during the first three to six months of life but these findings should be interpreted with some reservation because of possible selectivity in history-taking. EEG data suggest a significant excess of minor dysrhythmias and a deficit of centrencephalic and epileptiform patterns among hyperactives as compared with controls. It is concluded that the behavioural syndrome of chronic hyperactivity is not caused only by brain damage, though this is one of the possible aetiological agents. Other causes which could prove important are constitutional activity level, anxiety, and aberrant maturational development.