bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entanglement of Spin Transition and Elastic Interactions: Manipulating the Slow Spin Equilibrium by Guest-Mediated Fine-Tuning Elastic Frustration
Authors: Xue Jin-Peng , Chai Yuqiao , Yang Yu-Ting , Li Xing , Li Bao 
Published: September 2024

Abstract

A comprehensive analysis of the physical and chemical properties using the same family of complexes is crucial for understanding and designing structure-property relationships. However, finding the appropriate system remains challenging. Here, a series of guest-saturated states based on the 2D Hofmann-type framework [FeII(prentrz)2PdII(CN)4]·guest (prentrz = (1E,2E)-3-phenyl-N-(4H-1,2,4-triazol-4-yl)prop-2-en-1-imine, 1·guest) is reported, which exhibit a guest-manipulated slow dynamic effect of spin equilibrium in an incomplete two-step spin-crossover (SCO) process. Using a full-sealed method by modulating the mixing ratios and types of CH3OH, H2O, and D2O, stable maintenance of guest-saturated states allows fine-tuning elastic frustration (ξ) of the framework to realize SCO behaviors in the unexplored region between one-step incomplete (HS0.5LS0.5↔HS) and two-step complete (LS↔HS0.5LS0.5↔HS) processes. A semi-sealed method enables continuous guest molecule loss until the guest-saturated state disappears, transitioning slow spin equilibrium from difficult to overcome to overcome fully. The study demonstrates that guest molecule modulation is more controllable than structural deformation effects on elastic frustration, offering a pathway to discover hidden types of SCO materials and develop new stimulus-responsive materials.
Reduced GABA transmission onto ventral tegmental area dopamine neurons underlies vulnerability to a mouse model of Anorexia Nervosa
Authors: Ducrocq Fabien , Brouwer Eileen , Kooij Karlijn , Wolterink-Donselaar Inge , Drost Lisa , Hak Jaimie , Veendijk Melissa , Luijendijk Mieneke , Meye Frank , Adan Roger 
Published: September 2024

Abstract

Anorexia nervosa (AN) has the highest mortality among psychiatric diseases. Hyperactivity is a persistent symptom and alteration of mesolimbic dopamine transmission has been linked to the development and maintenance of the disease and of hyperactivity. However, whether local mesolimbic neurocircuit plasticity is causally involved remains unclear. Especially the role of local GABA control over dopamine neurons, a powerful regulator of the dopamine system, in an AN context is unresolved. We hypothesize that combining caloric restriction with exercise alters dopamine transmission via GABA disinhibition that, in turn, facilitates the expression of maladaptive behaviors such as hyperactivity. Therefore, we characterized the impact of the activity-based anorexia (ABA) model on the plasticity of the dopamine reward system using ex-vivo electrophysiology coupled with optogenetic manipulations. Ventral tegmental area dopamine (VTADA) neurons displayed a higher firing frequency in ABA-exposed animals compared to control mice. This coincided with reduced GABAergic transmission on VTADA neurons, at least in part attributable to decreased excitability of local VTA GABA (VTAGABA) neurons. Restoring the excitability of VTAGABA neurons via chemogenetic activation rescued mice from starvation, by decreasing running wheel activity. In summary, we found that the anorexic state leads to dysregulation of VTAGABA transmission on VTADA neurons that reinforces maladaptive behaviors such as hyperactivity. We uncovered a new mechanism linked to the disturbed dopamine system in ABA-exposed animals, identifying a hitherto unknown role of decreased local GABAergic control over VTA dopamine neuron output.
Phytochemical Screening and Pharmacological Investigations of Curculigo orchioides Leaf Extracts
Authors: Akh Tuz Mia Nur , Bhuia Md. Shimul , Islam Tawhida , Sultana Irin , Faruq Abdullah Al , Chowdhury Raihan , Ansari Siddique Akber , Ansari Irfan Aamer , Chowdhury M Mohi Uddin , Hasan Md. Abid , Saleh Na'il , Islam Muhammad Torequl 
Published: September 2024

Abstract

Curculigo orchioides Gaertn. (C. orchioides) is commonly known as Talamuli in Bangladesh. It is commonly distributed in Asian countries. The Indian (Ayurvedic) and Chinese traditional medicine systems use this plant frequently as an aphrodisiac herb for treating asthma and jaundice. Our study aimed to perform a comparative phytochemical analysis and evaluation of some biological effects using in vitro and in vivo approaches of its leaf’s ethanol (ECO), n-hexane (HCO), and chloroform (CCO) fractions. After extraction and fractionation, a phytochemical analysis was followed by different tests for anti-bacterial, antioxidant, anti-inflammatory, anti-diabetic, anti-diarrheal, and anxiolytic effects. High intensity was observed for the phytochemical groups, including alkaloids, glycosides, tannins, and reducing sugars in the fractions. Crude ECO did not cause death in Swiss mice up to a 3000 mg/kg acute oral dose. HCO was inactive against the test bacteria. ECO and CCO exhibited zones of inhibition against the bacteria within 9.89 ± 3.56 and 13.00 ± 1.00 mm. HCO exhibited better radical scavenging, alpha-amylase inhibition, and anti-diarrheal effects, while CCO significantly and effectively inhibited protein denaturation and membrane lysis and had hypoglycemic and anxiolytic effects. Taken together, C. orchioides might be a good source of phytotherapeutic agents.
A STUDY OF NON-INFECTIOUS PRURITUS IN PREGNANCY: CAUSES AND EVALUATION
Authors: SAMEEKSHA VERMA  , BEANT SINGH  , PARNEET KAUR  , DIMPLE CHOPRA  , RUPINDER KAUR  , SOWMYA  
Published: September 2024

Objectives: Itching is one of the most common complaints related to dermatosis during pregnancy occurring in 14–23% of pregnant women. Pregnancy-specific dermatoses constitute a heterogeneous group of pruritic skin eruptions seen exclusively during pregnancy and the postpartum period. These dermatoses may be linked to increased activity of maternal adrenal and pituitary glands, the development of fetal endocrine glands and are influenced by hormones such as progesterone, estrogen, and cortisone.
This study aims to evaluate various skin lesions during pregnancy. To explore the prevalence and variations of non-infectious pruritus in pregnancy and to evaluate the impact of non-infectious pruritus on maternal wellbeing.
Materials and methods: An observational prospective study was carried out on pregnant women presenting with complaints of pruritus. Data on socioeconomic status, demographics, obstetric history, medical conditions, and factors such as age, parity, and mode of delivery were collected. Neonatal outcomes, birthweight, NICU admission, morbidity, and mortality were documented.
Results: Majority of the subjects were in the age group of 20–30 years (77.5%). 88.1% resided in rural areas and 50% of the patients were primigravida. The majority (73.4%) of subjects had an onset of pruritus in the third trimester. The most common cause of pruritus was infectious (46.3%), specific dermatosis of pregnancy was observed in 37.6%, and in 13.8% of cases, pruritus was of unknown origin. IHCP was the most common cause of pruritus (40%). IHCP had the maximum number of preterm deliveries (36%), 48.5% of subjects had LSCS and induction was done in 45.4%.
Conclusion: Intrahepatic cholestasis of pregnancy is most prevalent among specific dermatosis of pregnancy which was associated with preterm deliveries, higher rate of induction, and LSCS.
A Review on Traditional Ayurveda Formulations and their Therapeutic Importance
Authors: Motghare Komal P. , Yeokar Vaibhav 
Published: September 2024

Ayurveda the therapeutic system of Indian medicine utilizes various types of dosage forms for health benefits including Vati, Churna, Kwatha, Asava, Arishta, Kalka and Avaleha, etc. The different formulations possess different Virya (potency) therefore they act in different way. Ayurveda specified uses of various formulation for different health benefits and some formulation meant for specified uses through different route of administration like; oral, topical and nasal formulations, etc. Ayurveda also recommended use of various formulations with in specified age group say for example Bhasma not very popular in children. The availability of large number of formulation options not only enhances patient compliance but also increases physician choices. The liquid, solid, semisolid and Dhupan (smoke) are some ayurveda drug formulations based on their appearance, these all formulations having their specific characteristics differ from each other. Present article explored the concept and importance of diversified ayurveda formulations used for various therapeutic purposes.
Keywords: Ayurveda, formulations, dosage forms, Virya.
The Enhancement of solubility and dissolution rate of saxagliptine hydrochloride by solid dispersion technique
Authors: Ghule Krushna Bhiva , Dhobale Shankar M. , Kedar Vikas D. , Jadhav Suresh L. 
Published: September 2024

Saxagliptine hydrochloride, PEG, polaxamer-407,ethyl cellulose were prepared to study the dissolution of sparingly water soluble Saxagliptine hydrochloride drug. solid dispersion of Saxagliptine hydrochloride were prepared using different ratios of PEG 6000 & Polaxamer-407.Some of the practical aspects to be considered for the preparation of solid dispersion such as selection of polymers ,methods of preparation solubility of drug and dissolution study of drug in solid dispersion are also discussed. The present research provides a there is increase in solubility of Saxagliptine hydrochloride and also solid dispersion complex of drug was giving better dissolution profile as compared to other solid dispersions this imporove bioavailability. FT-IR , shows the compatability of drug & carrier.
Keywords- solid dispersion, solubility enhancement, dissolution rate
Role of Quality Assurance Department in Pharmaceutical Industries: A Review
Authors: Saudagar Ravindranath , Doltade Mayuri 
Published: September 2024

The overview of the Quality Assurance Department in Pharmaceutical Industry is well discussed. It explains the vital role and the objectives of Quality Assurance Department. It also explains on how Quality Assurance can increase the revenue of the industry and how it is related to the other department as an important factor. This review gives the information about the role of Higher management and Importance of Quality Assurance in Pharmaceutical industry. It gives clear idea on how Quality Assurance Department works. The role of the Quality Assurance in Validation, Regulatory Affairs, and also in Business Development is explained.
Keywords: Quality Assurance, Regulatory Affairs, Objective, Importance, GMP.
Lafaz Kebahagiaan dalam Tafsir Al-Azhar
Authors: Savira Anggy 
Published: September 2024

One of the hopes and goals that humans want to achieve is happiness. This can be seen from the fact that humans try their best to achieve happiness in their lives. In the Qur'an happiness is expressed through various sentences and statements that express joy, pleasure, victory which is the foundation of human hope in life. The word that means happiness in the Qur'an is mentioned using several words, such as the word falāḥ, fawzan, fariḥa with various variations of each word. The purpose of the research is to find out the definition of happiness in the Qur'an, the lafaẓ expression of happiness in the Qur'an using Tafsir al-Azhar. The form of this research is library research using the Maudhu'i method. The data source in this study uses primary data, namely the book of Tafsir al-Azhar. The results showed that the meaning of happiness in Arabic is called sa'adah, which is taken from the root word sa'ada which means good and happy, found in QS. Hud: 105 and 108. Then lafaẓ which means happiness are: sa'adah, falāḥ, fawzan and fariḥa. HAMKA's interpretation in the book Tafsir al-Azhar is related to the lafaz of happiness in the verse: QS. Hud/11: 108, QS. Hajj/22: 77, QS. Al-Mu'minūn/23: 1, QS. al-A'la/87: 14, QS. Al-Shams/91: 9, QS. Al-Imran/3: 130 and 200, QS. Al-Tawbah/9: 88, QS. Al-Maidah/5: 35 dan 90, QS. Yunus/10: 64 dan QS. Hud/11: 10.
Abstrak: Salah satu harapan dan tujuan yang ingin dicapai manusia adalah kebahagiaan. Hal ini terlihat dari kenyataan yang menunjukkan bahwa manusia berusaha sekuat tenaga untuk mencapai kebahagiaan dalam hidupnya. Dalam al-Qur’an kebahagiaan diungkapkan melalui berbagai kalimat dan pernyataan yang mengungkapkan kegembiraan, kesenangan, kemenangan yang merupakan tumpuan harapan manusia dalam kehidupannya. Di dalam al-Qur’an kebahagiaan disebutkan dengan menggunakan beberapa kata yang bervariasi seperti kata falāḥ, fawzan, dan fariḥa. Tujuan penelitian adalah untuk mengetahui definisi kebahagiaan dalam al-Qur’an, ungkapan lafaẓ kebahagiaan dalam al-Qur’an dengan menggunakan Tafsir al-Azhar. Bentuk Penelitian ini adalah penelitian kepustakaan (library research) dengan menggunakan metode Maudhu’i. Sumber data dalam penelitian ini menggunakan data sekunder yaitu kitab Tafsir al-Azhar. Adapun hasil penelitian menunjukkan bahwa makna kebahagiaan dalam bahasa Arab disebut sa‘adah, yang diambil dari akar kata sa‘ada yang artinya adalah kebaikan dan bahagia, terdapat dalam QS. Hud: 105 dan 108. Kemudian lafaẓ yang semakna dengan kebahagiaan adalah: sa’adah, falāḥ, fawzan dan fariḥa. Penafsiran HAMKA dalam kitab Tafsir al-Azhar terkait dengan lafaz kebahagiaan pada ayat: QS. Hud/11: 108, QS. Hajj/22: 77, QS. Al-Mu’minūn/23: 1, QS. al-A’la/87: 14, QS. Al-Syams/91: 9, QS. Ali-Imran/3: 130 dan 200, QS. Al-Tawbah/9: 88, QS. Al-Maidah/5: 35 dan 90, QS. Yunus/10: 64 dan QS. Hud/11: 10.
The Implementation of Law Number 21 of 2008 Concerning Sharia Banking on Sharia Financial Institutions is Underway Sharia Economic Law Perspective
Authors: Rahma Fuji Alia , Noviarita Heni , Zaharah Rita 
Published: September 2024

The role of Law Number 21 of 2008 concerning Sharia Banking for Islamic financial institutions is very large, because currently Islamic financial institutions (LKS) have legal certainty to be able to carry out Islamic economic activities in Indonesia. The existence of the Sharia Banking Law provides an answer to the sustainability of the Islamic economy in Indonesia as a whole, both those that include the activities of Islamic financial institutions in the form of banks and non-banks. In this context, what is studied is the basis of sharia economic law and the implementation of Law Number 21 of 2008 in society. The purpose of this research is also to find out the legal position of sharia economics in Indonesia in accordance with the law being studied. This study uses library research with a qualitative research method, also known as a qualitative method of literature study. The results of this study are in accordance with the rules stated in its implementation, strengthened by a normative juridical point of view, which is the legal umbrella in the settlement of sharia economic disputes in Indonesia, namely Law Number 3 of 2006 concerning Religious Courts and Law Number 4 of 2004 about the Judicial Power as a form of upholding legal justice for the community in carrying out sharia economist activities in Indonesia, which is a reflection for the State of Indonesia in providing social justice for all Indonesian people. Keywords: Financial Institutions; Banking; Sharia;
Analysis of factors affecting investors’ decision towards cryptocurrency investments in Saudia Arabia: A moderating role of fear of missing out (FOMO) on decision-making
Authors: Hasan Asif , Alam Shahid , Habib Sufyan , Khan Mohammed Arshad 
Published: September 2024

This research aims to investigate the factors shaping the investment choices of individuals in Saudi Arabia concerning cryptocurrencies, particularly focusing on the influence of the Fear of Missing Out (FOMO) psychological phenomenon. This study employs a mixed-methods approach to comprehend the factors influencing Saudi investors' decisions in the cryptocurrency realm. Quantitative surveys are conducted to gauge perceptions of risk, return, regulatory factors, and social influence. Additionally, qualitative interviews delve into the nuanced interplay of these elements and the impact of FOMO on decision-making. Integrating the Theory of Planned Behavior and Behavioral Finance theories, this research offers a holistic understanding of cryptocurrency investment determinants. The combined quantitative and qualitative methods provide a comprehensive view, enabling an in-depth analysis of the subject matter. The study reveals that Saudi Arabian investors' decisions regarding cryptocurrencies are significantly influenced by multiple factors, including perceived risk, potential return, regulatory environment, and social dynamics. FOMO emerges as a crucial psychological factor, interacting with these influences and driving decision-making. This research underscores the intricate interplay between these factors and FOMO, shedding light on the dynamics of cryptocurrency investment choices in the Saudi Arabian market. The findings hold implications for policymakers, financial institutions, and investors seeking deeper insights into this evolving landscape. Drawing from the Theory of Planned Behavior and Behavioral Finance, it examines perceived risk, return, regulatory factors, and social influence in influencing cryptocurrency investment choices among Saudi investors, focusing on the influence of Fear of Missing Out (FOMO). The research outcome provides insights for policymakers, financial institutions, and investors seeking to understand cryptocurrency investment dynamics in Saudi Arabia.
Parasiticide use and obesity in dogs with sudden acquired retinal degeneration syndrome
Authors: McCarthy Paul M. G. , Whittaker Cameron J. , Annear Mathew J. , Hall Evelyn , Hamzianpour Negar , Irving William , Reynolds Benjamin D. , Smith Jeffrey S. , Thomasy Sara M. , Caruso Kelly A. 
Published: September 2024

Abstract

OBJECTIVE
To investigate parasiticide use and describe signalment features in patients with sudden acquired retinal degeneration syndrome (SARDS).

ANIMALS
Retrospective case-control study of dogs with (n = 71) and without (136) SARDS.

METHODS
Parasiticide use, presentation season, weight, body condition, and signalment were compared between dogs diagnosed with SARDS and the reference population by use of descriptive statistics and logistic regression.

RESULTS
Animals with SARDS were at a 5.99 times higher odds of having previously used imidacloprid (95% CI, 1.6 to 22.2; P = .003). However, time of last imidocloprid administration was > 6 years prior to diagnosis in 6 SARDS-affected individuals and 15, 26, or 42 months before diagnosis (n = 1 each). No other class of parasiticide had a significant association with SARDS. Seasonal variation was observed with a negative association identified between incidence of SARDS and tick season (October to January; P < .001). Overweight and obese dogs were 4.42 (95% CI, 1.9 to 10.4) and 4.96 (95% CI, 2.1 to 11.6) times more likely to have SARDS (P ≤ .001). History of polyphagia or weight gain was not associated with an increased likelihood of being overweight or obese within the SARDS-affected population (P > .108).

CLINICAL RELEVANCE
While a statistically significant association was found between imidacloprid use and SARDS, this is unlikely to be clinically significant given the lack of a temporal association, sparse exposure numbers, and low point estimate of the OR. A positive association between being overweight or obese and a diagnosis of SARDS was found independent of polyphagia and weight gain, suggesting that it may be a risk factor for the development of SARDS.
EFFECT OF DEHUMIDIFICATION ON Trigona spp. HONEY AS AN ANTIBACTERIAL AGAINST Streptococcus mutans
Authors: Pratiwi Deviyanti , Saristi Salsabila Shafa , Santosa Didi Nugroho , Rejeki Putri 
Published: September 2024

Honey comes from Trigona spp. has been known for its various health benefits and has the potential to be a natural ingredient that can be used as a preventive measure to inhibit and kill the main bacteria in dental caries (Streptococcus mutans). The dehumidification process using a humidifier is carried out to absorb honey water vapor so that the water content of the honey is reduced and the quality is better. The aim of this research is to determine the effect of dehumidification on Trigona spp. honey as an antibacterial for S.mutans. This research is a laboratory experiment with a post-test only control group design in vitro using the dilution method. Dehumidification is carried out on raw trigona honey to obtain dehumid trigona honey and honey water. As a control, 0.2% chlorhexidine and distilled water were used. The antibacterial activity test was carried out by calculating the total bacterial colonies using the total bacterial colony formula. The results of the study showed that the antibacterial activity of raw Trigona spp. honey had a significant difference against S.mutans with a total number of colonies of 0.4x106 CFU/mL compared to Trigona spp. dehum honey and honey water. Kruskal-Wallis analysis showed that there was a significant difference between the control group and the treatment group in inhibiting S.mutans. The conclusion is that raw Trigona spp. honey, Trigona spp. dehum honey, and honey water show differences in the antibacterial activity of S.mutans so that their use as a preventive measure in inhibiting S.mutans bacteria needs to be considered.

Keywords : dehumidification, Trigona spp. honey, antibacterial, Streptococcus mutans
NILAI DIAGNOSTIK CT SCAN ABDOMEN DAN MRCP DALAM PENENTUAN KAUSA OBSTRUKSI SALURAN BILIER
Authors: Badjeber Alvia Novita , Murtala Bachtiar , Muis Mirna , Alfian Andi , Daud Nu’man As 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui nilai diagnostik CT Scan Abdomen dan MRCP dalam penentuan kausa obstruksi saluran bilier. Penelitian ini dilaksanakan di Departemen Radiologi RSUP dr. Wahidin Sudirohusodo Makassar dengan jumlah sampel sebanyak 41 sampel yang masuk kriteria inklusi. Analisis dilakukan terhadap pemeriksaan CT scan abdomen dan MRCP pasien dengan obstruksi saluran bilier untuk menentukan penyebab dan lokasi obstruksi. Selanjutnya dilakukan perbandingan hasil dengan pemeriksaan dengan laporin operasi.
Hasil penelitian menunjukkan MDCT scan abdomen memiliki sensitivitas 67% dengan spesifisitas 100% dalam mendiagnosa batu; sensitivitas 100% dan spesifisitas 77.5% dalam mendiagnosa striktur jinak; sensitivitas 88% dan spesifisitas 100% dalam mendiagnosa massa, sedangkan MRCP memiliki sensitivitas 83.3% dengan spesifisitas 100% dalam mendiagnosa batu; sensitivitas 100% dengan spesifisitas 86.8% dalam mendiagnosis striktur jinak, sensitivitas 88% dan spesifisitas 100% dalam mendiagnosis massa. Terdapat kesesuaian hasil diagnosa antara MDCT Scan abdomen dan MRCP dengan hasil operasi untuk penentuan kausa dan lokasi obstruksi saluran biliaris. Dari hasil penelitian ini dapat disimpulkan bahwa MRCP memiliki nilai diagnostic accuracy, sensitivity, dan spesivisity yang lebih tinggi dibandingan CT scan abdomen dalam menentukan penyebab dan lokasi obstruksi saluran biliaris.
Kata Kunci : MDCT scan abdomen, MRCP, obstruksi saluran bilier