bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta‐analysis
Authors: Li Ronghua , Qiao Meng , Wang Xiaoyan , Zhao Xintong , Sun Qing 
Published: October 2016

SummaryBackgroundThe treatment of vitiligo is still one of the most difficult dermatological challenges, although there are many therapeutic options. Narrow band ultraviolet B (NB‐UVB) phototherapy is considered to be a very important modality for generalized vitiligo.ObjectiveThe aim of this study was to explore whether a combination of NB‐UVB and topical agents would be superior to NB‐UVB alone for treating vitiligo.MethodsWe searched the electronic databases such as PUBMED, EMBASE, Cochrane Library, and Web of Science. The primary outcome was the proportion of ≥50% repigmentation (a clinical significance), and secondary outcome was the proportion of ≥75% repigmentation (an excellent response).ResultsSeven randomized controlled trials (RCTs) involving 240 patients (413 lesions) were included in this meta‐analysis. The study showed no significant difference between NB‐UVB combination therapy (NB‐UVB and topical calcineurin inhibitor or vitamin D analogs) and NB‐UVB monotherapy in the outcomes of ≥50% repigmentation and ≥75% repigmentation. However, lesions located on the face and neck had better results in ≥50% repigmentation (RR = 1.40, 95% CI 1.08–1.81) and ≥75% repigmentation (RR = 1.88, 95% CI 1.10–3.20) with NB‐UVB and topical calcineurin inhibitor combination therapy vs. NB‐UVB monotherapy.ConclusionsThe meta‐analysis suggested that adding neither topical calcineurin inhibitors nor topical vitamin‐D3 analogs on NB‐UVB can yield significantly superior outcomes than NB‐UVB monotherapy for treatment of vitiligo. However, addition of topical calcineurin inhibitors to NB‐UVB may increase treatment outcomes in vitiligo affecting face and neck.
Generation of RUNX3 knockout pigs using CRISPR/Cas9‐mediated gene targeting
Authors: Kang J‐T , Ryu J , Cho B , Lee E‐J , Yun Y‐J , Ahn S , Lee J , Ji D‐Y , Lee K , Park K‐W 
Published: October 2016

ContentsPigs are an attractive animal model to study the progression of cancer because of their anatomical and physiological similarities to human. However, the use of pig models for cancer research has been limited by availability of genetically engineered pigs which can recapitulate human cancer progression. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us to generate genetically engineered pigs at a higher efficiency. In this study, specific CRISPR/Cas9 systems were used to target RUNX3, a known tumour suppressor gene, to generate a pig model that can induce gastric cancer in human. First, RUNX3 knockout cell lines carrying genetic modification (monoallelic or biallelic) of RUNX3 were generated by introducing engineered CRISPR/Cas9 system specific to RUNX3 into foetal fibroblast cells. Then, the genetically modified foetal fibroblast cells were used as donor cells for somatic cell nuclear transfer, followed by embryo transfer. We successfully obtained four live RUNX3 knockout piglets from two surrogates. The piglets showed the lack of RUNX3 protein in their internal organ system. Our results demonstrate that the CRISPR/Cas9 system is effective in inducing mutations on a specific locus of genome and the RUNX3 knockout pigs can be useful resources for human cancer research and to develop novel cancer therapies.
Physical activity and lung function decline in adults with asthma: The HUNT Study
Authors: Brumpton Ben M. , Langhammer Arnulf , Henriksen Anne H. , Camargo Carlos A. , Chen Yue , Romundstad Pål R. , Mai Xiao‐Mei 
Published: October 2016

ABSTRACTBackground and objectivePeople with asthma may seek advice about physical activity. However, the benefits of leisure time physical activity on lung function are unclear. We investigated the association between leisure time physical activity and lung function decline in adults with asthma.MethodsIn a population‐based cohort study in Norway, we used multiple linear regressions to estimate the annual mean decline in lung function (and 95% CI) in 1329 people with asthma over a mean follow‐up of 11.6 years. The durations of light and hard physical activity per week in the last year were collected by questionnaire. Inactive participants did not report any light or hard activity, while active participants reported light or hard activity.ResultsThe mean decline in forced expiratory volume in 1 s (FEV1
) was 37 mL/year among inactive participants and 32 mL/year in active participants (difference: −5 mL/year (95% CI: −13 to 3)). The mean decline in forced vital capacity (FVC) was 33 mL/year among inactive participants and 31 mL/year in active participants (difference: −2 mL/year (95% CI: −11 to 7)). The mean decline in FEV1
/FVC ratio was 0.36%/year among inactive participants and 0.22%/year in active participants (difference: −0.14%/year (95% CI: −0.27 to −0.01)). The mean decline in peak expiratory flow (PEF) was 14 mL/year among the inactive participants and 10 mL/year in active participants (difference: −4 mL/year (95% CI: −9 to 1)).ConclusionWe observed slightly less decline in lung function in physically active than inactive participants with asthma, particularly for FEV1, FEV1/FVC ratio and PEF.
Trade and civil conflict: Revisiting the cross‐country evidence
Authors: Calì Massimiliano , Mulabdic Alen 
Published: October 2016

AbstractWe revisit and expand the evidence on the impact of trade shocks on intra‐state conflict by using a large sample of developing countries in the 1960–2010 period. The results suggest that increases in the price of a country's exported commodities raise the country's risk of civil conflict and its duration. The effect on conflict risk is mainly driven by the price of point‐source commodities, in line with the rapacity effect theory of conflict. Intense trading with contiguous countries is associated with lower duration of conflict, consistent with the idea that such trade reduces the incentive of these countries to fuel conflict in their neighbor. Trading with neighbors is also associated with a lower risk of conflict when such trade occurs under trade agreements. On the other hand, we find no support for the opportunity cost theory via exported and imported commodities, nor via the economic cycle in export markets. We also identify a number of conditions under which the changes in the value of exported commodities cease to matter for conflict probability.
Lusi, a clastic‐dominated geysering system in Indonesia recently explored by surface and subsurface observations
Authors: Karyono Karyono , Obermann Anne , Lupi Matteo , Masturyono Masturyono , Hadi Soffian , Syafri Ildrem , Abdurrokhim Abdurrokhim , Mazzini Adriano 
Published: October 2016

AbstractThe spectacular eruption of Lusi began in NE Java, Indonesia, on 29 May 2006 and is still ongoing. Since its birth, Lusi has presented a pulsating activity marked by frequent eruptions of gas, water, mud and clasts. The aim of this study was to bridge subsurface and surface observations to describe Lusi's behaviour. Based on visual observations from 2014 to 2015, Lusi's erupting activity is characterised by four recurrent phases: (1) regular bubbling activity; (2) clastic geysering; (3) clastic geysering with mud bursts and intense vapour discharge; (4) quiescent phase. With a temporary network of five seismic stations deployed around the crater, we could identify tremor events related to phases 2 and 3. One of the tremor types shows periodic overtones that we associate with mud wagging in the feeder conduit. On the basis of our observations, we would describe Lusi as a sedimentary‐hosted hydrothermal system with clastic‐dominated geysering activity.
Dynamics of Epstein‐Barr viral load after hematopoietic stem cell transplantation and effect of preemptive rituximab therapy
Authors: Raberahona Mihaja , Wackenheim Chloe , Germi Raphaele , Carré Martin , Bulabois Claude‐Eric , Thiébaut Anne , Lupo Julien , Semenova Touyana , Cahn Jean‐Yves , Morand Patrice , Epaulard Olivier 
Published: October 2016

AbstractBackgroundEpstein‐Barr virus (EBV) displays oncogenic properties, particularly in the immunocompromised host. Notably, hematopoietic stem cell transplantation (HSCT) recipients with a detectable blood EBV viral load (BEBVL) are considered at higher risk of post‐transplant lymphoproliferative diseases (PTLD). Therefore, BEBVL is monitored after HSCT, and preemptive rituximab may be used in patients with high values. However, little is known about post‐HSCT BEBVL dynamics, and the threshold that should lead to anti‐CD20 therapy is poorly defined.MethodsWe retrospectively analyzed the post‐HSCT BEBVL of 332 adult HSCT recipients in our center from 2005 to 2013, including the effect of rituximab.ResultsDetection of BEBVL >100, 1000, 5000, 10 000, and 50 000 copies/mL occurred in, respectively, 77.7%, 69.6%, 37.0%, 27.1%, and 7.5% of the patients after a respective median time of 9, 14, 15, 16, and 14 weeks. No BEBVL threshold was associated with an overall survival difference. Seventy‐eight patients received rituximab, with a BEBVL decrease in most. Among patients with detectable BEBVL, long‐term survival did not differ in rituximab treated and non‐treated, except for patients with BEBVL ≥50 000. Only one case of PTLD was observed.ConclusionsBEBVL is frequently detectable after HSCT, but suggests no strong association with survival. Preemptive rituximab therapy threshold remains to be defined.
Gastrointestinal histoplasmosis in a patient after autologous stem cell transplant for multiple myeloma
Authors: Mohan Meera , Fogel Bradley , Eluvathingal Thomas , Schinke Carolina , Kothari Atul 
Published: October 2016

AbstractA 59‐year‐old patient with multiple myeloma on maintenance chemotherapy presented with fever, weight loss, and night sweats. An F‐18 fluorodeoxyglucose (FDG) positron emission tomography (PET) computed tomography (CT) showed intra‐abdominal lymphadenopathy with a mesenteric mass that led to further workup and diagnosis of histoplamosis. The patient was treated with amphotericin B and subsequently switched to itraconazole. This exemplifies the usefulness of FDG PET CT in diagnosis of infectious complications.
BK polyomavirus encephalitis in a patient with thrombotic microangiopathy after an allogeneic hematopoietic stem cell transplant
Authors: Jun Jae‐Bum , Choi Yunsuk , Kim Hawk , Lee Sun Ho , Jeong Joseph , Jung Jiwon 
Published: October 2016

AbstractTo date, only one case of BK polyomavirus (BKPyV) encephalitis combined with transplant‐associated thrombotic microangiopathy has been reported in an hematopoietic stem cell transplantation (HCT) recipient. We report the case of an HCT recipient who developed thrombotic microangiopathy and subsequent BKPyV encephalitis. She died despite treatment with cidofovir, ciprofloxacin, and intravenous immunoglobulin without improvement in mental status. Early suspicion of BKPyV encephalitis in an HCT recipient presenting with altered mental status and hemorrhagic cystitis is important.
Association between HIV infection and socio‐economic status: evidence from a semirural area of southern Mozambique
Authors: Pons‐Duran Clara , González Raquel , Quintó Llorenç , Munguambe Khatia , Tallada Joan , Naniche Denise , Sacoor Charfudin , Sicuri Elisa 
Published: October 2016

AbstractObjectivesTo analyse the association between socio‐economic status (SES) and HIV in Manhiça, a district of Southern Mozambique with one of the highest HIV prevalences in the world.MethodsData were gathered from two cross‐sectional surveys performed in 2010 and 2012 among 1511 adults and from the household census of the district's population. Fractional polynomial logit models were used to analyse the association between HIV and SES, controlling for age and sex and taking into account the nonlinearity of covariates. The inequality of the distribution of HIV infection with regard to SES was computed through a concentration index.ResultsFourth and fifth wealth quintiles, the least poor, were associated with a reduced probability of HIV infection compared to the first quintile (OR = 0.595, P‐value = 0.009 and OR = 0.474, P‐value < 0.001, respectively). Probability of HIV infection peaked at 36 years and then fell, and was always higher for women regardless of age and SES. HIV infection was unequally distributed across the SES strata.ConclusionsDespite the high HIV prevalence across the entire population of Manhiça, the poorest are at greatest risk of being HIV infected. While women have a higher probability of being HIV positive than men, both sexes showed the same infection reduction at higher levels of SES. HIV interventions in the area should particularly focus on the poorest and on women without neglecting anyone else, as the HIV risk is high for everyone.
Evaluation of acute traumatic coagulopathy in dogs and cats following blunt force trauma
Authors: Gottlieb Dara L. , Prittie Jennifer , Buriko Yekaterina , Lamb Kenneth E. 
Published: October 2016

AbstractObjectiveTo evaluate the presence of acute traumatic coagulopathy (ATC) in dogs and cats following blunt trauma and to relate coagulation variables with injury severity and admission variables.DesignProspective, single center, observational study from 2013 to 2014.SettingUrban private referral hospital.AnimalsEighteen and 19 client‐owned dogs and cats, respectively, sustaining blunt trauma within 8 hours of presentation without prior resuscitation; 17 healthy staff and client‐owned control catsMethodsBlood samples were collected upon presentation for measurement of blood gas, lactate, blood glucose, ionized calcium, PCV, total plasma protein, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, platelet count, and thromboelastography.
ResultsATC was diagnosed in 1 dog and 1 cat on presentation. Hypercoagulability was documented in 4/18 (22%) of dogs and 1/19 (5.3%) of cats. In dogs, prolongation of PT (P = 0.018), aPTT (P = 0.013) and decrease in maximum amplitude (MA) (P = 0.027) were significantly associated with injury severity as measured by the animal trauma triage (ATT) score. In cats, PT, aPTT, MA, and clot strength (G) were not associated with injury severity. In cats, increasing blood glucose and lactate were significantly associated with decreasing MA (P = 0.041, P = 0.031) and G (P = 0.014, P = 0.03). In both dogs (P = 0.002) and cats (P = 0.007), fibrinogen concentration was significantly correlated with G.ConclusionsATC is rare in minimally injured dogs and cats following blunt trauma. In dogs, ATT score is significantly associated with PT, aPTT, and MA, suggesting an increased risk of ATC in more severely injured animals. ATT score does not appear to predict coagulopathies in cats. Future studies including more severely injured animals are warranted to better characterize coagulation changes associated with blunt trauma.
Methods and Variables Associated with the Risk of Septic Arthritis Following Intra‐Articular Injections in Horses: A Survey of Veterinarians
Authors: Gillespie Caroline C. , Adams Stephen B. , Moore George E. 
Published: October 2016

ObjectiveTo determine common methods for intra‐articular injections and variables associated with the risk of septic arthritis following intra‐articular injection in the horse.Study DesignCross‐sectional survey.Sample PopulationEquine veterinarians.MethodsA link to an online survey was distributed to equine practitioners in 2014. Responses for descriptive data were tabulated. Data on infection rates obtained from medical records were analyzed. Variables associated with the risk of septic arthritis were determined using χ2 or Fisher's exact tests and logistic regression.ResultsCommon current methods for intra‐articular injections were determined from 241 surveys. Sixty‐four of 241 surveys (26.6%) contained data with numbers of joints injected and number of infections obtained from review of medical records. Eight different injection methods were used by more than 2/3 of responding veterinarians. A total of 67 out of 319,760 injected joints reported became septic following injection, giving an incidence of 2.10 septic joints per 10,000 intra‐articular injections. Based on multivariate analysis, infection rates were significantly lower when veterinarians prepared their own injection sites (OR=0.10) and had <20 years of practice experience (OR=0.025), whereas infection rates were significantly higher when hair was removed at the injection site (OR=19.70).ConclusionThere is a low incidence of septic arthritis following intra‐articular injection and a large number of injection methods reported by responding veterinarians. The low reported incidence of infection may be related to the large number of practitioners frequently using common methods.
Whole-Genome Sequence of the Nitrogen-Fixing Symbiotic Rhizobium Mesorhizobium loti Strain TONO
Authors: Shimoda Yoshikazu , Hirakawa Hideki , Sato Shusei , Saeki Kazuhiko , Hayashi Makoto 
Published: October 2016

ABSTRACT

Mesorhizobium loti
is the nitrogen-fixing microsymbiont for legumes of the genus
Lotus
. Here, we report the whole-genome sequence of a
Mesorhizobium loti
strain, TONO, which is used as a symbiont for the model legume
Lotus japonicus
. The whole-genome sequence of the strain TONO will be a solid platform for comparative genomics analyses and for the identification of genes responsible for the symbiotic properties of
Mesorhizobium
species.
Draft Genome Sequence of
Curtobacterium
sp. Strain UCD-KPL2560 (Phylum
Actinobacteria
)
Authors: Klein Brian A. , Lemon Katherine P. , Faller Lina L. , Jospin Guillaume , Eisen Jonathan A. , Coil David A. 
Published: October 2016

ABSTRACT

Here, we present the draft genome sequence of the actinobacterium
Curtobacterium
sp. strain UCD-KPL2560, which was isolated from the running surface of an indoor track field house in Medford, MA, USA (42.409716°N, -71.115169°W). The genome assembly contains 3,480,487 bp in 156 contigs.
Draft Genome Sequences of Two Novel
Pseudomonas
Strains Exhibiting Differential Hypersensitivity Reactions on Tobacco and Corn Seedlings
Authors: Tchagang Caetanie Fometeu , Xu Renlin , Mehrtash Shima , Rahimi Shabnam , Sidibé Aïssata , Li Xiang , Bromfield Eden S. P. , Tambong James Tabi 
Published: October 2016

ABSTRACT

Two novel
Pseudomonas
strains (S1E40 and S3E12) isolated from corn roots are antagonistic to
Rhizoctonia solani
and exhibit differential hypersensitivity reactions on tobacco and corn seedlings. We report here the draft genome sequences of strains S1E40 and S3E12, consisting of 6.98 and 7.06 Mb with 6,150 and 6,129 predicted protein-coding sequences, respectively.
Draft Genome Sequence of Ureolytic Environmental Isolate Bacillus galactosidilyticus PL133
Authors: Gaiero Jonathan R. , Formusa Philip A. , Hsiang Tom , Nicol Rob W. , Habash Marc 
Published: October 2016

ABSTRACT

We report here the 5.19-Mb draft genome sequence of
Bacillus galactosidilyticus
PL133 isolated from poultry litter. The isolate was an important member of the cultivable aerobic bacteria identified to have ureolytic activity, which is responsible for ammonia generation in poultry litter residue.
Draft Genome Sequences of Five Novel Polyketide Synthetase-Containing Mouse Escherichia coli Strains
Authors: Mannion Anthony , Shen Zeli , Feng Yan , Garcia Alexis , Fox James G. 
Published: October 2016

ABSTRACT

We report herein the draft genomes of five novel
Escherichia coli
strains isolated from surveillance and experimental mice housed at MIT and the Whitehead Institute and describe their genomic characteristics in context with the polyketide synthetase (PKS)-containing pathogenic
E. coli
strains NC101, IHE3034, and A192PP.
Draft Genome Sequence of Brazilian Escherichia coli Uropathogenic Strain E2
Authors: Paim Thiago G. S. , Pieta Luiza , Prichula Janira , Sambrano Gustavo E. , Soares Renata , Caierão Juliana , Frazzon Jeverson , d'Azevedo Pedro A. 
Published: October 2016

ABSTRACT

Escherichia coli
is a common pathogen recovered from cystitis infections. In this report, we announce the draft genome sequence of strain E2 isolated from the urine specimen from a female patient in South Brazil. The genome assembly has 5,081,209 bp, a G+C content of 50.57%, and virulence factors associated with both enteroaggregative and uropathogenic
E. coli
strains.
Complete Genome Sequence of a Bacterium Representing a Deep Uncultivated Lineage within the
Gammaproteobacteria
Associated with the Degradation of Polycyclic Aromatic Hydrocarbons
Authors: Singleton David R. , Dickey Allison N. , Scholl Elizabeth H. , Wright Fred A. , Aitken Michael D. 
Published: October 2016

ABSTRACT

The bacterial strain TR3.2, representing a novel deeply branching lineage within the
Gammaproteobacteria
, was isolated and its genome sequenced. This isolate is the first cultivated representative of the previously described “Pyrene Group 2” (PG2) and represents a variety of environmental sequences primarily associated with petrochemical contamination and aromatic hydrocarbon degradation.
Complete Chloroplast Genome Sequence of
Dendrobium nobile
from Northeastern India
Authors: Konhar Ruchishree , Biswal Devendra Kumar , Debnath Manish , Parameswaran Sriram , Sundar Durai , Tandon Pramod 
Published: October 2016

ABSTRACT

The orchid species
Dendrobium nobile
belonging to the family
Orchidaceae
and genus
Dendrobium
(a vast genus that encompasses nearly 1,200 species) has an herbal medicinal history of about 2000 years in east and south Asian countries. Here, we report the complete chloroplast genome sequence of
D. nobile
from northeastern India for the first time.
Complete Genome Sequence of a Recombinant GII.P16-GII.4 Norovirus Detected in Kawasaki City, Japan, in 2016
Authors: Matsushima Yuki , Shimizu Tomomi , Ishikawa Mariko , Komane Ayako , Okabe Nobuhiko , Ryo Akihide , Kimura Hirokazu , Katayama Kazuhiko , Shimizu Hideaki 
Published: October 2016

ABSTRACT
A recombinant norovirus, GII.P16-GII.4_Sydney2012, was first detected from nine patients with gastroenteritis in Kawasaki City, Japan, in 2016. The viral genome showed nucleotide sequence identities of 95.1% and 97.2% to the closest strains in the regions of 5′ terminus to ORF1 and ORF2 to 3′ terminus, respectively.
Complete Genomic Sequence of Campylobacter jejuni subsp.
jejuni
HS:19 Strain RM1285 Isolated from Packaged Chicken
Authors: Parker Craig T. , Huynh Steven , Heikema Astrid P. 
Published: October 2016

ABSTRACT

Poultry products serve as the main source of
Campylobacter jejuni
subsp.
jejuni
infections in humans.
C. jejuni
subsp.
jejuni
infections are a leading cause of foodborne gastroenteritis and are a prevalent antecedent to Guillain-Barré syndrome. This study describes the genome of
C. jejuni
subsp.
jejuni
HS:19 strain RM1285, isolated from packaged chicken in California.