bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Facebook to enhance learning experiences of students in computer programming at Introduction to Programming and Algorithm course
Authors: Özyurt Özcan , Özyurt Hacer 
Published: April 2016

ABSTRACTThe purpose of this study is to evaluate the effect of using Facebook on enriching the learning experiences of students in programming learning. In another word, the aim of the study is to detect the reflections from the environment of programming learning where Facebook is used. The study was carried out within the scope of the Introduction to Programming and Algorithm course taught in the software engineering department of the technology faculty of a university in Turkey. Initially, a Facebook group was created to enrich classroom teaching. Sixty‐three freshman engineering students taking the course and the faculty members of the department joined the group. The study was conducted for one semester in the fall semester of the 2014–2015 academic year. The Educational Usage of Facebook Scale (EUFS) and semi‐structured interview form were used as data collection tools in the study. Quantitative data were descriptively analyzed while qualitative data were subjected to content analysis. The results obtained in this study show that Facebook has positive effects such as providing a rich content in programming learning, increasing extracurricular communication, offering a cooperative and collaborative learning environment, increasing motivation, and bringing different perspectives as well as negative effects such as causing distraction, decreasing face‐to‐face communication, and bringing about problems about expressing oneself. As a result, it is possible to assert that Facebook can be efficiently used to support classroom teaching strategies and enrich learning experiences in programming learning. © 2016 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:546–554, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21730
AGK‐BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma
Authors: Cordioli Maria Isabel C. V. , Moraes Lais , Carvalheira Gianna , Sisdelli Luiza , Alves Maria Teresa S. , Delcelo Rosana , Monte Osmar , Longui Carlos A. , Cury Adriano N. , Cerutti Janete M. 
Published: April 2016

AbstractThyroid cancer is the fastest increasing cancer worldwide in all age groups. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer in both adults and children. PTC genomic landscape has been extensively studied in adults, but information regarding sporadic pediatric patients is lacking. Although BRAF V600E mutation is highly prevalent in adults, this mutation is uncommon in pediatric cases. As adult and pediatric PTC is a mitogen‐activated protein kinase‐driven cancer, this altered pathway might be activated by different genetic events. The aim of this study was to investigate the occurrence of AGK‐BRAF fusion gene, recently described in radiation‐exposed pediatric PTC, in a cohort of exclusively sporadic pediatric PTC. The series consisted of 30 pediatric PTC younger than 18 years of age at the time of diagnosis and 15 matched lymph node metastases (LNM). Primary tumors and matched LNM were screened for the presence of the AGK‐BRAF fusion transcript by RT‐PCR. To confirm the identity of the amplified products, randomly selected samples positive for the presence of the fusion transcripts were sequenced. Moreover, BRAF dual‐color, break‐apart probes confirmed BRAF rearrangement. Overall, the AGK‐BRAF fusion gene was detected in 10% (3/30) of primary tumors. For one of these cases, paired LNM was also available, which also shows the presence of AGK‐BRAF fusion gene. This study described, for the first time, the presence of AGK‐BRAF in sporadic pediatric PTC. Understanding the molecular events underlying pediatric PTC may improve preoperative diagnosis, allow molecular prognostication and define a therapeutic approach toward sporadic PTC patients.
The real role of pseudokinase: linking diabetes to cancers
Authors: Li Ke , Hu Zhuowei 
Published: April 2016

AbstractA recent paper in Nature Communications shows that pseudokinase TRIB3 has a critical role in the development of diabetes‐related cancers via interacting with SQSTM1, a selective autophagy receptor. Interrupting the TRIB3‐SQSTM1 interaction using an α‐helix peptide shows a significant antitumor effect both in normal and diabetic mice. This work provides a potential strategy against cancers in patients with diabetes.
Chemical Diversity and Antimicrobial Activity of Salvia multicaulis Vahl Essential Oils
Authors: Fahed Layal , Stien Didier , Ouaini Naïm , Eparvier Véronique , El Beyrouthy Marc 
Published: April 2016

The chemical compositions and antimicrobial activities of the essential oils (EOs) of aerial parts of Salvia multicaulis Vahl, collected during the same week from two different Lebanese regions, were investigated. The EOs were obtained by hydrodistillation using a Clevenger‐type apparatus and characterized by GC and GC/MS analyses. The minimum inhibitory concentrations of these EOs were determined against one Gram‐negative and two Gram‐positive bacteria, one yeast, and five dermatophytes using the broth microdilution technique. One EO was notably active against Staphylococcus aureus, methicillin‐resistant S. aureus, and all of the Trichophyton species tested. Nerolidol was found to be the major compound in the active oil; nerolidol was also absent from the inactive oil. This study demonstrated that nerolidol shows antimicrobial activity and therefore significantly contributes to the antimicrobial potential of the oil. The chemical diversity of worldwide S. multicaulis EOs was analyzed, revealing that the EOs of this study belong to two different chemotypes found in the literature. The nerolidol chemotype appears to be restricted to Lebanon, and it can be used as antimicrobial agent against external bacterial and fungal infections.
Multiplexed Imaging of Protein Phosphorylation on Membranes Based on TiIV Functionalized Nanopolymers
Authors: Iliuk Anton , Li Li , Melesse Michael , Hall Mark C. , Tao W. Andy 
Published: April 2016

AbstractAccurate protein phosphorylation analysis reveals dynamic cellular signaling events not evident from protein expression levels. The most dominant biochemical assay, western blotting, suffers from the inadequate availability and poor quality of phospho‐specific antibodies for phosphorylated proteins. Furthermore, multiplexed assays based on antibodies are limited by steric interference between the antibodies. Here we introduce a multifunctionalized nanopolymer for the universal detection of phosphoproteins that, in combination with regular antibodies, allows multiplexed imaging and accurate determination of protein phosphorylation on membranes.
Unexpected Photo‐instability of 2,6‐Sulfonamide‐Substituted BODIPYs and Its Application to Caged GABA
Authors: Takeda Aoi , Komatsu Toru , Nomura Hiroshi , Naka Masamitsu , Matsuki Norio , Ikegaya Yuji , Terai Takuya , Ueno Tasuku , Hanaoka Kenjiro , Nagano Tetsuo , Urano Yasuteru 
Published: April 2016

AbstractInvestigation of the unexpected photo‐instability of 2,6‐sulfonamide‐substituted derivatives of the boron dipyrromethene (BODIPY) fluorophore led to the discovery of a photoreaction accompanied by multiple bond scissions. We characterized the photoproducts and utilized the photoreaction to design a caged γ‐aminobutyric acid (GABA) derivative that can release GABA upon irradiation in the visible range (>450 nm). This allowed us to stimulate neural cells in mouse brain slices.
Adaptation and Diversification of an RNA Replication System under Initiation‐ or Termination‐Impaired Translational Conditions
Authors: Mizuuchi Ryo , Ichihashi Norikazu , Yomo Tetsuya 
Published: April 2016

AbstractAdaptation to various environments is a remarkable characteristic of life. Is this limited to extant complex living organisms, or is it also possible for a simpler self‐replication system to adapt? In this study, we addressed this question by using a translation‐coupled RNA replication system that comprised a reconstituted translation system and an RNA “genome” that encoded a replicase gene. We performed RNA replication reactions under four conditions, under which different components of translation were partly inhibited. We found that replication efficiency increased with the number of rounds of replication under all the tested conditions. The types of dominant mutations differed depending on the condition, thus indicating that this simple system adapted to different environments in different ways. This suggests that even a primitive self‐replication system composed of a small number of genes on the early earth could have had the ability to adapt to various environments.
The impact of US Government assistance on recidivism
Authors: Costopoulos Julie S. , Plewinski Amy M. , Monaghan Patricia L. , Edkins Vanessa A. 
Published: April 2016

AbstractBackgroundCommunity re‐entry from custody programmes facilitate access to community resources, such as cash assistance and food stamps, with the aim of reducing criminal recidivism. Evidence that these programmes achieve is mainly from longer‐term prisoners rather than short‐term jail inmates.AimThe aim of the study is to test the hypothesis that facilitating access to community resources while still in jail would reduce re‐arrest rates among former jail inmates in the USA.MethodsCommunity resources offered to the jail inmates participating in this study included Medicaid, food stamps and cash assistance. Participants who opted to sign up for these social services were matched with non‐applicants based on date of release (n = 101). Each participant's criminal history was coded prior to release from the jail and at three months, six months and one year after release.ResultsContrary to our original hypotheses, recidivism was not significantly reduced in the applicant group. People released after facilitated access to community assistance had an increase in drug offence severity at six months after release. Recidivism also differed by age and race.ConclusionThe substance offences in the applicant group suggested that cash benefits provided the released offender with the means to sustain their substance misuse. Treatment for substance misuse should be incorporated with other resources in order to reduce recidivism effectively. Copyright © 2016 John Wiley & Sons, Ltd.
Aortic annulus to left coronary distance as a predictor for persistent left bundle branch block after TAVI
Authors: Hein‐Rothweiler Ralph , Jochheim David , Rizas Konstantinos , Egger Alexander , Theiss Hans , Bauer Axel , Massberg Steffen , Mehilli Julinda 
Published: April 2016

ObjectivesTo identify potential predictors for ventricular conduction delay and to evaluate the impact of interventricular dyssynchrony on mortality after implantation of a balloon‐expandable aortic valve (BEV).Methods and resultsClinical, computertomographical (CT), and electrocardiographical (ECG) data from 225 transcatheter aortic valve implantation (TAVI) patients were analyzed. Procedures were performed between May 2010 and September 2013 via transfemoral access using a BEV. Incidence of new‐onset left bundle branch block (NOP‐LBBB) at discharge was 23.1% (n = 52). Predictive factors for NOP‐LBBB were first degree atrioventricular (AV) block (odds ratio (OR): 3.91, 95% confidence interval (CI): 1.58 to 9.64), area cover index (OR: 1.83, 95% CI: 1.26 to 2.67), annulus calcification > first degree (OR: 3.01, 95% CI: 1.36 to 6.66), and annulus to left coronary distance (OR: 0.65, 95% CI: 0.44 to 0.96). At 1‐year follow‐up, no significant difference was observed concerning all‐cause mortality (15.6% among non NOP‐LBBB and 9.6% among NOP‐LBBB patients, P = 0.278) and cardiovascular mortality (4.6% among non NOP‐LBBB and 5.8% among NOP‐LBBB patients, P = 0.737).ConclusionIn addition to previous predictors, annulus to left coronary distance and area cover index have been identified as new predictors for NOP‐LBBB. NOP‐LBBB showed no relevant impact on mortality after one year. Further investigation including larger populations and longer follow‐up is required to confirm these findings and develop an algorithm for identification of patients at risk for NOP‐LBBB associated adverse events. © 2016 Wiley Periodicals, Inc.
Comparison of transradial coronary procedures via right radial versus left radial artery approach: A meta‐analysis
Authors: Shah Rachit M. , Patel Dhavalkumar , Abbate Antonio , Cowley Michael J. , Jovin Ion S. 
Published: April 2016

IntroductionCoronary angiography and angioplasty via transradial approach is shown to be associated with significant reduction in access site complications. Due to a lack of sufficient data, the use of the right or left radial approach is still operator‐dependent. We performed a meta‐analysis of prospective randomized studies to compare right versus left radial artery approach for coronary procedures.MethodsWe found 12 randomized studies meeting the predetermined inclusion criteria. A total of 6,450 patients were included in the meta‐analysis of which 3,217 patients underwent coronary procedures via right radial approach and 3,233 patients via left radial approach. The primary endpoint was the comparison of fluoroscopy time, procedure time, contrast use and cross‐over rates between two radial approaches.ResultsPooled analysis of the included studies showed a similar rate of cross‐over events (4.2% for right radial approach vs. 4.1% for left radial approach, odds ratio (OR)=1.08, P = 0.68), and similar total procedure times (18.8 ± 10.3 min vs. 18.1 ± 10.0 min, standard difference (SD) of the mean = 0.09, P = 0.162) between the two radial approaches. However, the right radial approach was found to be associated with minimally longer fluoroscopy times (5.8 ± 4.4 min vs. 5.3 ± 4.2 min, SD of the mean = 0.157, P < 0.001) and greater contrast use (84 ± 35 mL vs. 82 ± 34 mL, SD of the mean = 0.082, P = 0.003). Access site complications and the incidence of stroke were similar between two radial approaches.ConclusionOur meta‐analysis suggests a small but statistically significant difference in terms of contrast use and fluoroscopy time in favor of coronary procedures performed via left radial approach in comparison to right radial approach without any significant difference in access site or other procedural complications between the two radial approaches. © 2016 Wiley Periodicals, Inc.
Rationale and design of the ARCUS: Effects of trAnsRadial perCUtaneouS coronary intervention on upper extremity function
Authors: Zwaan Eva M. , IJsselmuiden Alexander J.J. , van Rosmalen Joost , van Geuns Robert‐Jan M. , Amoroso Giovanni , Moerman Esther , Ritt Marco J.P.F. , Schreuders Ton A.R. , Kofflard Marcel J.M. , Holtzer Carlo A.J. 
Published: April 2016

ObjectiveThe aim of this study is to provide a complete insight in the access‐site morbidity and upper extremity function after Transradial Percutaneous Coronary Intervention (TR‐PCI).BackgroundIn percutaneous coronary intervention the Transradial Approach (TRA) is gaining popularity as a default technique. It is a very promising technique with respect to post‐procedure complications, but the exact effects of TRA on upper extremity function are unknown.Methods and resultsThe effects of trAnsRadial perCUtaneouS coronary intervention on upper extremity function (ARCUS) trial is a multicenter prospective cohort study that will be conducted in all patients admitted for TR‐PCI. Clinical outcomes will be monitored during a follow‐up of 6 months, with its primary endpoint at two weeks of follow‐up. To investigate the complete upper extremity function, a combination of physical examinations and validated questionnaires will be used to provide information on anatomical integrity, strength, range of motion (ROM), coordination, sensibility, pain, and functioning in everyday life. Procedural and material specifications will be registered in order to include all possible aspects influencing upper extremity function.ConclusionsResults from this study will elucidate the effect of TR‐PCI on upper extremity function. This creates the opportunity to further optimize TR‐PCI, to make improvements in functional outcome and to prevent morbidity regarding full upper extremity function. © 2016 Wiley Periodicals, Inc.
Predicting long‐term bleeding after percutaneous coronary intervention
Authors: Sharma Praneet K. , Chhatriwalla Adnan K. , Cohen David J. , Jang Jae‐Sik , Baweja Paramdeep , Gosch Kensey , Jones Philip , Bach Richard G. , Arnold Suzanne V. , Spertus John A. 
Published: April 2016

ObjectivesTo construct a model to predict long‐term bleeding events following percutaneous coronary intervention (PCI).BackgroundTreatment with dual antiplatelet therapy following PCI involves balancing the benefits of preventing ischemic events with the risks of bleeding. There are no models to predict long‐term bleeding events after PCI.MethodsWe analyzed 1‐year bleeding outcomes from 3,128 PCI procedures in the Patient Risk Information Services Manager (PRISM) observational study. Patient‐reported bleeding events were categorized according to Bleeding Academic Research Consortium (BARC) definitions. Logistic regression analysis was used to develop a model predicting BARC ≥ 1 bleeding.ResultsBARC 0, 1, 2 or 3 bleeding was observed in 574 (18.4%); 2382 (76.2%); 114 (3.6%); and 58 (1.8%) patients, respectively. Compared to patients who had no bleeding, patients with BARC ≥ 1 bleeding were more often female (30 vs. 23%), Caucasian (94 vs. 83%), had a higher incidence of drug eluting stent (DES) implantation (83 vs. 76%) and warfarin therapy (7.4 vs. 3.9%), and a lower incidence of diabetes (31 vs. 45%; P‐value <0.01 for all comparisons). A 27‐variable model had moderate discrimination (c‐statistic of 0.674), and good calibration, as did a parsimonious model with 10 variables (c‐statistic = 0.667). This model performed well in predicting BARC ≥ 2 bleeding events as well (c‐statistic = 0.653).ConclusionsBleeding is common in the first year after PCI, and can be predicted by pre‐procedural patient characteristics and use of DES. Objective estimates of bleeding risk may help support shared decision‐making with respect to stent selection and duration of antiplatelet therapy following PCI. © 2016 Wiley Periodicals, Inc.
Paraffin Oil Emulsions for the Absorption of Toluene Gas
Authors: Qi Min , Wu Xiankun , Zhang Feng , Zhang Juan , Wang Yueyang , Zhang Zhibing , Chen Qiang 
Published: April 2016

AbstractWater‐in‐oil‐in‐water (W/O/W) and water‐in‐oil (W/O) emulsions of paraffin oil were prepared with sorbitan monooleate (Span 80)/polyoxyethylene sorbitan monooleate (Tween 80) or polyethylene glycol monostearate (SG‐6), respectively. The physical characteristics and the absorption of toluene gas in these emulsions were investigated to evaluate the influence of the emulsifier dosage and the oil/water ratio. Both investigated W/O/W emulsions provided high stabilities and low viscosities. The absorption of toluene gas was excellent, with little foam occurring during the absorption. Although the W/O emulsions with 2–5 % SG‐6 were of high stability, their high viscosities strongly limited their application as volatile organic compound absorbents. Stable emulsions consisted of small and uniform droplets and some emulsions underwent mild demulsification after the absorption.
Generation of Two‐Phase Air‐Water Flow with Fine Microbubbles
Authors: Levitsky Inna , Tavor Dorith , Gitis Vitaly 
Published: April 2016

AbstractAiming at the development of a low‐cost technology for multipurpose water and surface treatment in the chemical industry and beyond, using microbubbles, a novel scheme of liquid‐gas interaction within a specially designed bubble generator was tested. Its efficiency for the production of microbubbles with a size distribution in the micron range is confirmed. The basic element of the device is a vortex chamber with water supply through tangential ducts, while the gas (air) is introduced in a highly turbulent swirling flow of water in radial direction through the orifice in the gas supply duct, located on the chamber axis. Bubble diameters, bubble velocities in the pipe flow and effect of the output pressure on the bubble size distribution were studied.
Encapsulation of Agents inside Crystals as Liquid Inclusions
Authors: Seidel Julia , Ulrich Joachim 
Published: April 2016

AbstractThere are many approaches to the issue of agent encapsulation as a method to protect sensitive substances against outer influences. The possibility of the use of inclusion‐containing crystals as encapsulation material was investigated. Since many products are water‐based media, the low‐water‐soluble substance salicylic acid (SA) was chosen to investigate its qualities as a container substance. Therefore, the solubility of SA was investigated in dependence on the proportions of the antisolvent water and the solvent ethanol by means of a ternary phase diagram. Moreover, SA container crystals were generated and filled by means of an antisolvent crystallization method. In two case studies, copper sulfate and ascorbic acid could successfully be encapsulated.
High‐Performance Low‐Temperature Li+ Intercalation in Disordered Rock‐Salt Li–Cr–V Oxyfluorides
Authors: Chen Ruiyong , Ren Shuhua , Mu Xiaoke , Maawad Emad , Zander Stefan , Hempelmann Rolf , Hahn Horst 
Published: April 2016

AbstractAt −10 °C and 26 mA g−1, Li2Cr0.2V0.8O2F can deliver a stable high capacity of 250 mAh g−1 (or 690 Wh kg−1) over 60 cycles. Even at −20 °C and a current density of 106 mA g−1, it still delivers a steady capacity and specific energy of about 160 mAh g−1 and 400 Wh kg−1, respectively, over 100 cycles. Superior performance of Li2Cr0.2V0.8O2F over Li2VO2F and Li2CrO2F is related to its structural stability and electronic properties.
CO2 Electroreduction with Enhanced Ethylene and Ethanol Selectivity by Nanostructuring Polycrystalline Copper
Authors: Kwon Youngkook , Lum Yanwei , Clark Ezra L. , Ager Joel W. , Bell Alexis T. 
Published: April 2016

AbstractThere are a number of recent reports on the use of oxidation/reduction cycling of Cu surfaces to improve their selectivity for ethylene formation in the aqueous CO2 reduction reaction. Here, the oxidation/reduction process is examined in detail. It is found that the faradaic efficiencies for both ethylene and ethanol are enhanced after oxidation/reduction cycling in the presence of halide anions. Specifically, cycling of the electrode in the presence of chloride, bromide, or fluoride anions allows for an ethylene faradaic efficiency of approximately 15.2 %, a factor of 1.5 higher than that for polycrystalline copper (at −1.0 V vs. RHE). The faradaic efficiency for ethanol is also enhanced from 2.65 to approximately 7.6 %. The effects of electrochemical oxidation/reduction with the chloride anion were investigated by using in situ Raman spectroscopy, and the changes in the surface morphology of copper were monitored by using SEM. Consistent with prior reports, it is observed that during the oxidation part of the cycle, anodic corrosion forms a Cu2O layer, which consists of cubical crystals of about 150 nm. During the reduction sweep, it is converted to metallic copper, which forms irregular Cu nanoparticles of around 20 nm in diameter. The enhancement in ethylene formation is presumably attributed to the formation of grain boundaries, which may serve as active sites.