bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and characterisation of Al‐doped ZnO and PVDF composites
Authors: Peihai Ju , Ling Weng , Lizhu Liu , Xiaorui Zhang 
Published: November 2016

A single organic composite material having high dielectric constant is difficult to meet the needs of the market. Nowadays, polymer matrix‐based composites have become a promising option that researchers are focusing on. Al‐doped zinc oxide (ZnO) and composites containing ZnO as reinforcement and poly(vinylidene fluoride) (PVDF) as matrix were prepared. The microstructure of composites was analysed by scanning electron microscope and transmission electron microscopy techniques. The chemical structures and crystallisation behaviour of the materials were investigated by the means of FT‐IR and X‐ray diffractometer. ZnO, having both rod‐ and sheet‐shaped, was evenly distributed within the PVDF material. Additionally, the dielectric properties and breakdown field strength of composite were tested. As the content of the fillers was kept steady, the dielectric constant of the composite material increased proportionally with the Al content. Thus, a composite containing 10% ZnO with 7% Al displayed a dielectric constant of 18.5 at 100 Hz, twice when compared with the pure ZnO/PVDF composites. This phenomenon was attributed to ZnO semiconductor properties which can significantly improve the conductive nature of the materials.
Effects of chirality on single‐file water permeability and diffusivity through single wall carbon nanotubes
Authors: Binesh Alireza R. , Kamali Reza 
Published: November 2016

In this work, molecular dynamics (MD) simulations of single‐file water permeation through carbon nanotube (CNT) membranes have been performed and for a better understanding of the relationship between water transport performance of these biomimetic membranes and chirality of CNTs, the key parameters such as osmotic and diffusive permeability constants and diffusion coefficients are investigated. For this purpose, CNTs with approximately same diameters and different chirality from armchair to zigzag are used to perform 40 nanosecond MD simulations of these membranes. The resulting permeability and diffusivity characteristics of single‐file CNT membranes showed that water permeability constant and diffusion coefficient increase by changing in the chirality of CNTs from armchair to zigzag, with approximately similar size in diameter. Finally, the presented results provide useful insights into the design of CNT water transporters with best performance.
Divergence of ectodermal and mesodermal gene regulatory network linkages in early development of sea urchins
Authors: Erkenbrack Eric M. 
Published: November 2016

Significance
Sea urchins (echinoids) consist of two subclasses, cidaroids and euechinoids. Research on gene regulatory networks (GRNs) in the early development of three euechinoids indicates that little appreciable change has occurred to their linkages since they diverged ∼90 million years ago (mya). I asked whether this conservation extends to all echinoids. I systematically analyzed the spatiotemporal expression and function of regulatory genes segregating euechinoid ectoderm and mesoderm in a cidaroid. I report marked divergence of GRN architecture in early embryonic specification of the oral–aboral axis in echinoids. Although I found evidence for diverged regulation of both mesodermal and ectodermal genes, comparative analyses indicated that, since these two clades diverged 268 mya, mesodermal GRNs have undergone significantly more alterations than ectodermal GRNs.
Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) case presentation and comparison with other polyarthritides affecting older people
Authors: Eguia Hans A. , Parodi Garcia José Francisco , Ramas Diez Covadonga , Eguia A. Edwin A. 
Published: November 2016

Abstract
Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome mainly affects elderly men and responds well to steroids. Since this syndrome can resemble other diseases, its diagnosis is a significant challenge. Through the following paper, we hope to improve the diagnosis of RS3PE by presenting a table comparing RS3PE to two other common polyarthritic conditions affecting the elderly.
Evaluation of the New Compound Oxathiapiprolin for Control of Downy Mildew in Basil
Authors: Patel Jaimin S. , Novaes Maria I. Costa de , Zhang Shouan 
Published: November 2016

This study was conducted to evaluate a new chemical, oxathiapiprolin, as a seed treatment and foliar application for control of downy mildew of basil, caused by Peronospora belbahrii, and to assess the in vitro sensitivity of P. belbahrii to oxathiapiprolin. In the greenhouse, both foliar application and seed treatment with oxathiapiprolin significantly (P < 0.05) reduced downy mildew severity on basil and increased width of cotyledons compared to the non-treated control. In field experiments, foliar applications of oxathiapiprolin alone, as a tank mixture, or in alternation with azoxystrobin, potassium phosphite, or tea tree oil significantly reduced downy mildew severity and increased the basil yield compared to the non-treated control. In the laboratory test, EC50 values of sensitive P. belbahrii isolates ranged from 0.00033 μg/ml to 0.00040 μg/ml oxathiapiprolin, providing important information on baseline sensitivity of P. belbahrii to oxathiapiprolin. The results indicate that oxathiapiprolin can be applied as foliar applications in combination or in alternation with azoxystrobin or potassium phosphite to control the disease effectively. Accepted for publication 1 November 2015. Published 13 November 2015.
Carcinogenesis of Vulvar Lesions: Morphology and Immunohistochemistry Evaluation
Authors: Rivero Raquel Camara , Garcia Deborah , Hammes Luciano Serpa , Cerski Marcelle Reesink , Magno Valentino , Kliemann Lúcia Maria , Capp Edison 
Published: November 2016

Objectives
The aim of the study was to assess the 2 pathways of vulvar carcinogenesis and correlate immunohistochemical expression of p53 with histopathological findings.

Materials and Methods
This cross-sectional study included 76 cases. Patients were classified according to the 2004 International Society for the Study of Vulvovaginal Disease Terminology, followed by a review of clinical records and immunohistochemical staining for p53.

Results
Fifteen cases were in the human papillomavirus (HPV)-associated pathway (12 cases of usual vulvar intraepithelial neoplasia [VIN] and 3 of warty squamous cell carcinoma [SCC]), and 13 cases were in the HPV-independent pathway (5 cases of differentiated VIN and 8 of keratinizing SCC). Significant differences in p53 expression were observed between the 2 pathways of carcinogenesis: in the lesions related to the HPV-independent pathway, the percentage of p53-positive cells was greater (>25%, p < .001), and the staining pattern was basal (extending into the middle layer) in differentiated VIN and diffuse or infiltrative in warty SCC (p < 0.001). In the lesions HPV-associated pathway, p53 staining was less extensive (≤10% of cells, p < 0.001) and followed basal pattern in usual VIN, whereas warty SCCs were negative for p53 (p < 0.001).

Conclusions
Unique patterns of histological appearance and p53 expression can separate vulvar lesions into 2 distinct pathways of carcinogenesis. We propose that p53 immunohistochemistry may be performed simultaneously with histopathological examination in all cases of VIN and vulvar SCC, because it would aid in definition of the pathway of carcinogenesis and thus enable better clinical follow-up of patients with these conditions.
Value of IgA tTG in Predicting Mucosal Recovery in Children With Celiac Disease on a Gluten‐Free Diet
Authors: Leonard Maureen M. , Weir Dascha C. , DeGroote Maya , Mitchell Paul D. , Singh Prashant , Silvester Jocelyn A. , Leichtner Alan M. , Fasano Alessio 
Published: November 2016

ABSTRACTObjectives:Our objective was to determine the rate of mucosal recovery in pediatric patients with celiac disease on a gluten‐free diet. We also sought to determine whether immunoglobulin A tissue transglutaminase (tTG) correlates with mucosal damage at the time of a repeat endoscopy with duodenal biopsy in these patients.Methods:We performed a retrospective chart review of 103 pediatric patients, younger than 21 years, with a diagnosis of celiac disease defined as Marsh 3 histology, and who underwent a repeat endoscopy with duodenal biopsy at least 12 months after initiating a gluten‐free diet.Results:We found that 19% of pediatric patients treated with a gluten‐free diet had persistent enteropathy. At the time of the repeat biopsy, tTG was elevated in 43% of cases with persistent enteropathy and 32% of cases in which there was mucosal recovery. Overall the positive predictive value of the autoantibody tTG was 25% and the negative predictive value was 83% in patients on a gluten‐free diet for a median of 2.4 years.Conclusions:Nearly 1 in 5 children with celiac disease in our population had persistent enteropathy despite maintaining a gluten‐free diet and immunoglobulin A tTG was not an accurate marker of mucosal recovery. Neither the presence of symptoms nor positive serology were predictive of a patient's histology at the time of repeat biopsy. These findings suggest a revisitation of monitring and management criteria of celiac disease in childhood.
Legal and ethical issues of using brain imaging to diagnose pain
Authors: Davis Karen D. 
Published: November 2016

Abstract
Pain, by definition, is a subjective experience, and as such its presence has usually been based on a self-report. However, limitations of self-reports for pain diagnostics, particularly for legal and insurance purposes, has led some to consider a brain-imaging–based objective measure of pain. This review will provide an overview of (1) differences between pain and nociception, (2) intersubject variability in pain perception and the associated brain structures and functional circuits, and (3) capabilities and limitations of current brain-imaging technologies. I then discuss how these factors impact objective proxies of pain. Finally, the ethical, privacy, and legal implications of a brain-imaging–based objective measure of pain are considered as potential future technological developments necessary to create a so-called “painometer test.”
The Role of Agonistic Striving in the Association Between Cortisol and High Blood Pressure
Authors: Ewart Craig K. , Elder Gavin J. , Jorgensen Randall S. , Fitzgerald Sheila T. 
Published: November 2016

ABSTRACT

Objective
A social action theory of chronic stress proposes that agonistic striving (seeking to influence or control others) impairs cardiovascular health by magnifying the impact of high adversity-induced cortisol levels on blood pressure. We tested three predictions of social action theory: (1) the social action theory taxonomy of regulatory strivings characterizes young adults from high-adversity neighborhoods; (2) high cortisol levels predict high blood pressure more reliably in the subgroup with the agonistic striving profile than in subgroups with other profiles; (3) the association of higher cortisol and higher blood pressure with agonistic striving is not explained by negative affect (depressive symptoms/dysphoria, anger, hostility).

Methods
Participants were young adults (N = 198, mean [SD] age = 32 [3.4] years); 71% female; 65% black) from disadvantaged urban neighborhoods. Motive profiles (including agonistic strivings) were assessed using the Social Competence Interview. Cortisol levels were derived from saliva samples; blood pressure level was obtained during two days of ambulatory monitoring. Psychological measures of negative affect were assessed using questionnaires.

Results
The predicted taxonomy of regulatory strivings was replicated in this sample; the interaction between cortisol and motive profile was significant (F(2, 91) = 6.72, p = .002); analyses of simple effects disclosed that higher cortisol levels predicted higher ambulatory blood pressure only in individuals who exhibited agonistic striving. Depressive symptoms/dysphoria, trait anger, and hostility were not correlated with agonistic striving, cortisol, or blood pressure.

Conclusions
Agonistic striving may represent a distinctive (and novel) social-cognitive mechanism of toxic stress and cardiovascular risk.
Interrogating the Topological Robustness of Gene Regulatory Circuits
Authors: Huang Bin , Lu Mingyang , Jia Dongya , Ben-Jacob Eshel , Levine Herbert , Onuchic Jose N. 
Published: November 2016

AbstractOne of the most important roles of cells is performing their cellular tasks properly for survival. Cells usually achieve robust functionality, for example cell-fate decision-making and signal transduction, through multiple layers of regulation involving many genes. Despite the combinatorial complexity of gene regulation, its quantitative behavior has been typically studied on the basis of experimentally-verified core gene regulatory circuitry, composed of a small set of important elements. It is still unclear how such a core circuit operates in the presence of many other regulatory molecules and in a crowded and noisy cellular environment. Here we report a new computational method, named random circuit perturbation (RACIPE), for interrogating the robust dynamical behavior of a gene regulatory circuit even without accurate measurements of circuit kinetic parameters. RACIPE generates an ensemble of random kinetic models corresponding to a fixed circuit topology, and utilizes statistical tools to identify generic properties of the circuit. By applying RACIPE to simple toggle-switch-like motifs, we observed that the stable states of all models converge to experimentally observed gene state clusters even when the parameters are strongly perturbed. RACIPE was further applied to a proposed 22-gene network of the Epithelial-to-Mesenchymal transition (EMT), from which we identified four experimentally observed gene states, including the states that are associated with two different types of hybrid Epithelial/Mesenchymal phenotypes. Our results suggest that dynamics of a gene circuit is mainly determined by its topology, not by detailed circuit parameters. Our work provides a theoretical foundation for circuit-based systems biology modeling. We anticipate RACIPE to be a powerful tool to predict and decode circuit design principles in an unbiased manner, and to quantitatively evaluate the robustness and heterogeneity of gene expression.
Evaluation of the accuracy of imputed sequence variants and their utility for causal variant detection in cattle
Authors: Pausch Hubert , MacLeod Iona M , Fries Ruedi , Emmerling Reiner , Bowman Phil J , Daetwyler Hans D , Goddard Michael E 
Published: November 2016

AbstractBackgroundThe availability of dense genotypes and whole-genome sequence variants from various sources offers the opportunity to compile large data sets consisting of tens of thousands of individuals with genotypes at millions of polymorphic sites that may enhance the power of genomic analyses. The imputation of missing genotypes ensures that all individuals have genotypes for a shared set of variants.ResultsWe evaluated the accuracy of imputation from dense genotypes to whole-genome sequence variants in 249 Fleckvieh and 450 Holstein cattle usingMinimacandFImpute. The sequence variants of a subset of the animals were reduced to the variants that were included in the Illumina BovineHD genotyping array and subsequently inferredin silicousing either within-or multi-breed reference populations. The accuracy of imputation varied considerably across chromosomes and dropped at regions where the bovine genome contains segmental duplications. Depending on the imputation strategy, the correlation between imputed and true genotypes ranged from 0.898 to 0.952. The accuracy of imputation was higher withMinimacthanFImputeparticularly for variants with low MAF. Considering a multi-breed reference population increased the accuracy of imputation, particularly whenFImputewas used to infer genotypes. When the sequence variants were imputed usingMinimac, the true genotypes were more correlated to predicted allele dosages than best-guess genotypes. The computing costs to impute 23,256,743 sequence variants in 6958 animals were ten-fold higher withMinimacthanFImpute. Association studies with imputed sequence variants revealed seven quantitative trait loci (QTL) for milk fat percentage. Two causal mutations in theDGAT1andGHRgenes were the most significantly associated variants at two QTL on chromosomes 14 and 20 whenMinimacwas used to infer genotypes.ConclusionsThe population-based imputation of millions of sequence variants in large cohorts is computationally feasible and provides accurate genotypes. However, the accuracy of imputation is low at regions where the genome contains large segmental duplications or the coverage with array-derived SNPs is poor. Using a reference population that includes individuals from many breeds increases the accuracy of imputation particularly at low-frequency variants. Considering allele dosages rather than best-guess genotypes as explanatory variables is advantageous to detect causal mutations in association studies with imputed sequence variants.
Cognitive impairment in older people with alcohol use disorders in a UK community mental health service
Authors: Rao Rahul 
Published: November 2016

Purpose
The assessment of cognitive impairment in community services for older people remains under-explored. The paper aims to discuss this issue.

Design/methodology/approach
Cognitive impairment was examined in 25 people aged 65 and over with alcohol use disorders, on the caseload of community mental health services over a six-month period. All subjects assessed using Addenbrooke’s Cognitive Assessment (ACE-III).

Findings
In total, 76 per cent of the group scored below the cut-off point for likely dementia but only 45 per cent of people scored below the cut-off point for tests of language, compared with 68-84 per cent people in other domains.

Research limitations/implications
This finding has implications for the detection of alcohol-related brain cognitive impairment in clinical settings.

Practical implications
Standardised cognitive testing is common within mental health services for older people, but may also have utility within addiction services.

Social implications
The early detection of alcohol-related cognitive impairment can improve social outcomes in both drinking behaviour and the social consequences of alcohol-related dementia.

Originality/value
This may be the first published study of cognitive impairment in patients under a mental team for older people with alcohol use disorders and offers some unique findings within this sampling frame.
Antecedents and consequences of psychological contract breach
Authors: Peng J.C. , Jien Jia-Jing , Lin Julian 
Published: November 2016

PurposeThe purpose of this paper is to investigate store-level servant leadership and the procedural justice climate (PJC) as key antecedents for employee-perceived psychological contract breach (PCB) and explores the mediating roles of PCB in the relationships among servant leadership, the PJC and deviant employee behavior.Design/methodology/approachSurvey data were collected from 301 employees at 94 stores of a restaurant chain in Taiwan. The model and hypotheses were tested using hierarchical linear modeling.FindingsThe results support the moderated mediation model, showing that the indirect effects of servant leadership and PJC on deviant employee behavior through PCB were stronger for employees with an external locus of causality attribution than for those with an internal locus.Research limitations/implicationsThe study relied on cross-sectional survey design, therefore the authors cannot infer causality.Practical implicationsThe results will help organizations and managers understand that supervisor servant leadership has suppressive effects on deviant employee behavior through the intermediary mechanism of negative psychological perception (i.e. the perception of a PCB).Originality/valueThe primary purpose of this study is to examine the influences of store-level servant leadership and the PJC on employee deviance and to examine the mediating role played by PCB. The findings suggest a significantly negative relationship.
Construction and application of specialty-term information for document re-ranking
Authors: Chou Shihchieh , Dai Zhangting 
Published: November 2016

Purpose
Conventional studies mainly classify a term’s appearance in the retrieved documents as either relevant or irrelevant for application. The purpose of this paper is to differentiate the term’s appearances in the retrieved documents in more detailed situations to generate relevance information and demonstrate the applicability of the derived information in combination with current methods of query expansion.

Design/methodology/approach
A method was designed first to utilize the derived information owing to term appearance differentiation within a conventional query expansion approach that has been proven as an effective technology in the enhancement of information retrieval. Then, an information retrieval system was developed to demonstrate the realization and sustain the study of the method. Formal tests were conducted to examine the distinguishing capability of the proposed information utilized in the method.

Findings
The experimental results show that substantial differences in performances can be achieved between the proposed method and the conventional query expansion method alone.

Practical implications
Since the proposed information resides at the bottom of the information hierarchy of relevance feedback, any technology regarding the application of relevance feedback information could consider the utilization of this piece of information.

Originality/value
The importance of the study is the disclosure of the applicability of the proposed information beyond current usage of term appearances in relevant/irrelevant documents and the initiation of a query expansion technology in the application of this information.
User communication behavior in mobile communication software
Authors: Lin Kuan-Yu 
Published: November 2016

Purpose
The purpose of this paper is to develop a research model examining users’ perceived needs-technology fit of mobile communication software through motivational needs and technological characteristics. The study investigated the effects of perceived needs-technology fit on user satisfaction and intention to continue using mobile communication software.

Design/methodology/approach
This study proposes a research model based on task-technology fit theory and uses and gratification theory, incorporating key determinants of users’ continuance intention toward mobile communication software. An online survey instrument was developed to collect data, and 403 questionnaires were used to test the relationships in the proposed model.

Findings
The causal model was validated using AMOS 21.0, and all nine study hypotheses were supported. The results indicated that users’ perceived needs-technology fit and satisfaction were crucial antecedents of their intention to continue using mobile communication software and that they mediated the influence of users’ needs as well as technological characteristics.

Practical implications
Mobile communication software practitioners should focus on enhancing users’ perceived needs-technology fit through motivational needs (utilitarian, hedonic, and social needs) and technological characteristics (mobile convenience, service compatibility, and user control) to further boost user satisfaction and intention to continue using mobile communication software services.

Originality/value
This study contributes to a theoretical understanding of factors explaining users’ continuance intention toward mobile communication software.