bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sephardic Migration and Cultural Transfer: The Ottoman and Spanish Expansion through a Cinquecento Jewish Lens
Authors: Jacobs Martin 
Published: December 2017

Abstract
This study explores the reading and writing practices of Joseph Ha-Kohen, a sixteenth-century Jewish chronicler from Genoa, against the background of his Italian and Spanish sources: in what ways and why did he adapt, change or subvert their narratives? It focuses on two of Ha-Kohen’s major works: his Franco-Turkish Chronicle, and his Hebrew adaptation of López de Gómara’s account of the Spanish conquests in the Americas. Based on these writings, the essay asks how the author’s Sephardic identity and migration experience inform his ideas about the Habsburg and Ottoman Empires. Notably, the Jewish chronicler applauds the Ottomans’ conversion of churches into mosques, while he condemns the forced Christianization of the Amerindians. At the same time, Ha-Kohen shares cultural attitudes with Gómara and voices qualified support for a Spanish civilizing mission. These ambiguities in Ha-Kohen’s writings—oscillating between praise and repudiation of imperial ideology—prove to be emblematic of post-expulsion Sephardic Jewry.
Gateway to the Syriac Saints: A Database Project
Authors: Saint-Laurent Jeanne-Nicole Mellon 
Published: December 2017

This article describes The Gateway to the Syriac Saints, a database project developed by the Syriac Reference Portal (www.syriaca.org). It is a research tool for the study of Syriac saints and hagiographic texts. The Gateway to the Syriac Saints is a two-volume database: 1) Qadishe and 2) Bibliotheca Hagiographica Syriaca Electronica (BHSE).
Hagiography, the lives of the saints, is a multiform genre. It contains elements of myth, history, biblical exegesis, romance, and theology. The production of saints’ lives blossomed in late antiquity alongside the growth of the cult of the saints. Scholars have attended to hagiographic traditions in Greek and Latin, but many scholars have yet to discover the richness of Syriac hagiographic literature: the stories, homilies, and hymns on the saints that Christians of the Middle East told and preserved. It is our hope that our database will give scholars and students increased access to these traditions to generate new scholarship.
The first volume, Qadishe or “saints” in Syriac, is a digital catalogue of saints or holy persons venerated in the Syriac tradition. Some saints are native to the Syriac-speaking milieu, whereas others come from other linguistic or cultural traditions. Through the translation of their hagiographies and the diffusion of saints’ cults in the late antique world, saints were adopted, “imported,” and appropriated into Syriac religious memory.
The second volume, the BHSE, focuses on Syriac hagiographic texts. The BHSE contains the titles of over 1000 Syriac stories, hymns, and homilies on saints. It also includes authors’ or hagiographers’ names, the first and last lines of the texts (in Syriac, English, and French), bibliographic information, and the names of the manuscripts containing these hagiographic works. We have also listed modern and ancient translations of these works.
All of the data in the Gateway to the Syriac Saints has been encoded in TEI, and it is fully searchable, linkable, and open.
Sentinel Lymph Node Biopsy Pathology and 2-Year Postsurgical Recurrence of Breast Cancer in Kenyan Women
Authors: Brand Nathan R. , Wasike Ronald , Makhdomi Khalid , Chauhan Rajendra , Moloo Zahir , Gakinya Samuel M. , Neugut Alfred I. , Zujewski Jo Anne , Sayed Shahin 
Published: December 2017

Purpose The goal of this study was to describe the pathologic findings and early follow-up experience of patients who underwent a sentinel lymph node biopsy (SLNB) at Aga Khan University Hospital (AKUH) between 2008 and 2017. Patients and Methods We performed a retrospective analysis of women with breast cancer who underwent an SLNB at AKUH between 2008 and 2017. The SLNB was performed on patients with stage I and stage II breast cancer, and identification of the sentinel lymph node was made by radioactive tracer, blue dye, or both, per availability and surgeon preference. Demographic, surgical, and pathologic data, including immunohistochemistry of the surgical sample for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, were abstracted from the patient records. Follow-up data were available for a subset of patients. Results Between 2008 and 2017, six surgeons performed SLNBs on 138 women, 129 of whom had complete records and were included in the study. Thirty-one of 129 (24%) had a positive SLNB, including 10 of 73 (14%) with stage I and 21 of 56 (38%) with stage II disease. Seventy-eight patients (60%) received systemic adjuvant chemotherapy and 79 (62%) received radiation therapy, and of the 102 patients who were estrogen receptor positive, 86 (85%) received endocrine therapy. Seventy-nine patients were observed for > 2 years, and, of these, four (5.1%) had a regional recurrence. Conclusion The SLNB positivity rates were similar to those of high-income country (HIC) cohorts. However, preliminary data suggest that recurrence rates are elevated at AKUH as compared with those of HIC cohorts, perhaps because of a lower use of radiotherapy and chemotherapy at AKUH compared with HIC cohorts or because of differences in the characteristics of the primary tumor in patients at AKUH as compared with those in HICs.
Oxytocin and Naltrexone Successfully Treat Hypothalamic Obesity in a Boy Post-Craniopharyngioma Resection
Authors: Hsu Eugenie A , Miller Jennifer L , Perez Francisco A , Roth Christian L 
Published: December 2017

Abstract

Context
Hypothalamic obesity, a treatment-resistant condition common to survivors of craniopharyngioma (CP), is strongly associated with a poor quality of life in this population. Oxytocin (OT), a hypothalamic neuropeptide, has been shown to play a role in the regulation of energy balance and to have anorexigenic effects in animal studies. Naltrexone (NAL), an opiate antagonist, has been shown to deter hedonic eating and to potentiate OT’s effects.

Design
In this parent-observed study, we tested the administration of intranasal OT for 10 weeks (phase 1), followed by a combination of intranasal OT and NAL for 38 weeks (phase 2) in a 13-year-old male with confirmed hypothalamic obesity and hyperphagia post-CP resection. Treatment resulted in 1) reduction in body mass index (BMI) z score from 1.77 to 1.49 over 10 weeks during phase 1; 2) reduction in BMI z score from 1.49 to 0.82 over 38 weeks during phase 2; 3) reduced hyperphagia during phases 1 and 2; 4) continued hedonic high-carbohydrate food-seeking in the absence of hunger during phases 1 and 2; and 5) sustained weight reduction during decreased parental monitoring and free access to unlocked food in the home during the last 10 weeks of phase 2.

Conclusion
This successful intervention of CP-related hypothalamic obesity and hyperphagia by OT alone and in combination with NAL is promising for conducting future studies of this treatment-recalcitrant form of obesity.
Classification of breast cancer in ultrasound imaging using a generic deep learning analysis software: a pilot study
Authors: Becker Anton S , Mueller Michael , Stoffel Elina , Marcon Magda , Ghafoor Soleen , Boss Andreas 
Published: December 2017

Objective:
To train a generic deep learning software (DLS) to classify breast cancer on ultrasound images and to compare its performance to human readers with variable breast imaging experience.

Methods:
In this retrospective study, all breast ultrasound examinations from January 1, 2014 to December 31, 2014 at our institution were reviewed. Patients with post-surgical scars, initially indeterminate, or malignant lesions with histological diagnoses or 2-year follow-up were included. The DLS was trained with 70% of the images, and the remaining 30% were used to validate the performance. Three readers with variable expertise also evaluated the validation set (radiologist, resident, medical student). Diagnostic accuracy was assessed with a receiver operating characteristic analysis.

Results:
82 patients with malignant and 550 with benign lesions were included. Time needed for training was 7 min (DLS). Evaluation time for the test data set were 3.7 s (DLS) and 28, 22 and 25 min for human readers (decreasing experience). Receiver operating characteristic analysis revealed non-significant differences (p-values 0.45–0.47) in the area under the curve of 0.84 (DLS), 0.88 (experienced and intermediate readers) and 0.79 (inexperienced reader).

Conclusion:
DLS may aid diagnosing cancer on breast ultrasound images with an accuracy comparable to radiologists, and learns better and faster than a human reader with no prior experience. Further clinical trials with dedicated algorithms are warranted.

Advances in knowledge:
DLS can be trained classify cancer on breast ultrasound images high accuracy even with comparably few training cases. The fast evaluation speed makes real-time image analysis feasible.
New Estonian records: mosses
Authors: Vellak Kai , Ingerpuu Nele , During Heinjo , Flatberg Kjell Ivar , Leis Mare , Ehrlich Loore , Kannukene Leiti , Kupper Tiiu 
Published: December 2017

In 2016 four species new to Estonia have been identified, mainly by checking earlier collections in different herbaria. This addition raises the total number of bryophyte species registered in Estonia up to 598. One species, which was evaluated as extinct in Estonia, has been found in a new locality. Also a variety new for Estonia has been found.
Extensão universitária em Relações Internacionais: ditadura e transição à democracia na América do Sul | Science outreach in the field of International Relations: dictatorship and transitional justice in South America
Authors: Dri Clarissa , Da Silva Andressa Caroline Molinari , De Andrade Marina Lazarotto 
Published: December 2017

Este artigo traz o relato e a discussão de uma iniciativa de extensão universitária e educação popular promovida no âmbito do curso de Relações Internacionais da Universidade Federal de Santa Catarina. Trata-se de analisar a implementação e os resultados do projeto de extensão “Pedro e o Capitão”, que levou a discussão sobre ditaduras militares e transição à democracia na América do Sul para escolas públicas de ensino médio da grande Florianópolis. A arte foi o método escolhido para dialogar sobre direitos humanos com os jovens, sendo a encenação da peça teatral “Pedro y el Capitán”, de Mario Benedetti, a principal base para a interação. Após análise de conteúdo dos debates com as turmas, conclui-se que o diálogo social sobre o período ditatorial ainda é escasso, o que alimenta a desinformação e opiniões pré-concebidas sobre práticas de violência de Estado.ABSTRACT This paper reports and discusses an initiative of social interaction and popular education organized within the undergraduate career of International Relations of Federal University of Santa Catarina. It analyzes the implementation and the results of the project “Pedro and the captain”, which discussed military dictatorships and democratic transition in South America in secondary public schools in Florianopolis. Art served as a method for human rights dialogue with students, for the play “Pedro y el Capitán”, by Mario Benedetti, was the main basis for interaction. The content analysis of debates among student groups reveals that social dialogue in Brazil on the authoritarian period is still rare, which accounts for lack of information and pre-conceived opinions on State violence. Palavras-chave: Transição democrática. América do Sul. Extensão universitária.Keywords: Democratic transition. South America. University social projects.Recebido em 30 de Julho de 2016 | Aceito em 15 de Setembro de 2017Received July 30, 2016 | Accepted on September 15, 2017DOI: 10.12957/rmi.2016.24898
Embaixador Sérgio Tutikian: um pioneiro no Oriente Médio | Ambassador Sérgio Tutikian: a pioneer in the Middle East
Authors: Goldfeld Monique Sochaczewski 
Published: December 2017

Sérgio Tutikian é um pioneiro por dois motivos: por um lado é dos primeiros diplomatas de origem armênia nos quadros do Ministério das Relações Exteriores e por outro é o primeiro a de fato ter servido nos postos-chave do Oriente Médio, dominando muitas de suas línguas, aspectos culturais e sensibilidades políticas. O depoimento em questão é uma entrevista de História Oral, do tipo história de vida, em que o entrevistado conta sobre a história da chegada da sua família ao Brasil, no contexto das perseguições porque os armênios passaram no Império Otomano em sua fase final, perpassa o estabelecimento da mesma no Rio Grande do Sul, sua escolha não óbvia pela carreira diplomática, e centra-se então em seus testemunhos sobre passagens no Irã, Iraque e Kuwait, entre outras localidades médio-orientais. ABSTRACTSérgio Tutikian is a pioneer for two reasons: on the one hand, he is one of the first diplomats of Armenian origins in the Brazilian Ministry of Foreign Affairs, and on the other hand he is the first one to have served in the key posts of the Middle East, mastering many local languages, cultural aspects and political sensitivities. The testimony here is an Oral History interview, in which the deponent shares the story of the arrival of his family in Brazil - in the context of persecutions the Armenians suffered in the last phase of the Ottoman Empire -, their settlement in Rio Grande do Sul, his non obvious choice for the diplomatic career, and then focuses his testimony on events he witnessed in Iran, Iraq and Kuwait, among other Middle Eastern places.Palavras-chave: Diplomacia; Armênios; Diáspora; Oriente Médio.keywords: Diplomacy; Armenians; Diaspora; Middle East.Recebido em 09 de Novembro de 2017 | Aceito em 11 de Novembro de 2017Received on November 9, 20017 | Accepted on November 11, 2017DOI: 10.12957/rmi.2016.31421
Bauman, Zygmunt. Estranhos à nossa porta. Rio de Janeiro: Zahar, 2017, 117P. ISBN 978-85-378-1610-3
Authors: De' Carli Camila 
Published: December 2017

O texto traz uma breve resenha do livro Estranhos à nossa porta, do sociólogo e filósofo polonês Zygmunt Bauman, publicado no Brasil pela editora Zahar em 2017. O autor analisa as origens e o impacto do pânico moral gerado pelos intensos fluxos migratórios para a Europa nos últimos anos, assim como o processo de desumanização que envolve os recém-chegados ao continente, que tem transformado as migrações de tema moral em uma questão de segurança.ABSTRACTThis short review examines the book Strangers at our door, written by the sociologist and philosopher Zygmunt Bauman and published in Brazil by Zahar (2017). The author analyzes the origins and the impact of the moral panic generated by the intense migratory flows to Europe in recent years, as well as the process of dehumanization involving the newcomers, wich has made migrations become a matter of security rather than a moral issue.Palavras-chave: Europa, migrações, refugiados.Keywords: Europe, migration, refugees.Recebido em 27 de Novembro de 2017 | Aceito em 29 de Novembro de 2017.Received on November 27, 2017 | Accepted on November 29, 2017.DOI: 10.12957/rmi.2016.31471
From bullfighter’s lover to female matador: The evolution of Madonna’s gender displays in her music videos
Authors: Tortajada Iolanda , Araüna Núria , Willem Cilia 
Published: December 2017

Abstract
Throughout her artistic career, Madonna has been notorious for her provocative gender displays. Academic literature has highlighted the ambivalence of many of her performances in this regard: although she occupies masculine spaces and roles, she often adopts positions that are in line with a traditional kind of femininity or with representation patterns that are part of and reinforce patriarchal discourse. Our analysis of Madonna’s music videos reveals the transformation that takes place in the artist’s gender displays. In this analysis we pay special attention to postfeminist features such as self-sexualization and the use of violence. Through three of the artist’s videos that employ the bullfighting metaphor, we see how the representation of femininity embodied by Madonna is transformed – within the framework of a sexual and affective relationship – from her position as a victim and passive female to that of aggressor.
P.Oxy. VIII 1080 A Fresh Edition and Textual Notes on a Miniature Codex of the Apocalypse
Authors: Malik Peter 
Published: December 2017

AbstractThis is an updated edition of P.Oxy. VIII 1080, a miniature codex of the Johannine Apocalypse. Besides further the discussion of the manuscript' s palaeographical and codicological features, it also includes a brief analysis of its text and corrections.
Integrating Genomic and Proteomic Data: The Integr8 Project
Authors: Pruess Manuela , Kersey Paul , Apweiler Rolf 
Published: December 2017

Summary Integr8 (http://www.ebi.ac.uk/integr8/) has been developed to provide an integration layer for the exploitation of genomic and proteomic data. High-quality databases from major bioinformatics centres in Europe are included, and some core data and the relationships of biological entities to each other and to entries in other databases are stored. Thus, a framework exists that allows for new kinds of data to be integrated, and an entity-centric view of complete genomes and proteomes is offered. Integr8 is an automatically populated database, providing different entry points to the data, depending on the user’s entity of interest. The Proteome Analysis database for statistical analysis and the Genome Reviews for annotated genome information are the main developments within the Integr8 project. With the BioMart application, an interactive querying tool for performing customisable proteome analysis and data mining is offered. Future developments will especially focus on the Genome Reviews, including mapping not yet annotated protein sequences onto their corresponding genomes, generating new predictions for non-coding RNA genes, and generally extending the scope to lower metazoan organisms.
Gene prediction by multiple syntenic alignment
Authors: Adi Said S. , Ferreira Carlos E. 
Published: December 2017

Summary Given the increasing number of available genomic sequences, one now faces the task of identifying their functional parts, like the protein coding regions. The gene prediction problem can be addressed in several ways. One of the most promising methods makes use of similarity information between the genomic DNA and previously annotated sequences (proteins, cDNAs and ESTs). Recently, given the huge amount of newly sequenced genomes, new similarity-based methods are being successfully applied in the task of gene prediction. The so-called comparative-based methods lie in the similarities shared by regions of two evolutionary related genomic sequences. Despite the number of different gene prediction approaches in the literature, this problem remains challenging. In this paper we present a new comparative-based approach to the gene prediction problem. It is based on a syntenic alignment of three or more genomic sequences. With syntenic alignment we mean an alignment that is constructed taking into account the fact that the involved sequences include conserved regions intervened by unconserved ones. We have implemented the proposed algorithm in a computer program and confirm the validity of the approach on a benchmark including triples of human, mouse and rat genomic sequences.
Dynamic Network Reconstruction from Gene Expression Data Describing the Effect of LiCl Stimulation on Hepatocytes
Authors: Zellmer Sebastian , Schmidt-Heck Wolfgang , Gaunitz Frank , Baldysiak-Figiel Alicja , Guthke Reinhardt , Gebhardt Rolf 
Published: December 2017

Summary Wnt/β-catenin signalling plays an important role in zonation of liver parenchyma and in patterning of hepatocyte heterogeneity. A characteristic marker of this heterogeneity is glutamine synthetase, which is expressed only in a subset of pericentrally located hepatocytes. To investigate, whether and how the Wnt/β-catenin signalling pathway is involved a culture of hepatocytes was stimulated by LiCl. This resulted in an increase in the specific GS activity, indicating that the Wnt/β-catenin pathway may participate in regulating GS levels. Affymetrix GeneChip oligonucleotide arrays were used to monitor the gene expression changes during a period from 2 to 24 hours after stimulation by LiCl. Samples from a cultivation without stimulation were used as controls. Based on the gene expression profiles a hypothetic signal transduction network was constructed by a reverse engineering algorithm. The network robustness was tested and the most stable structure was identified.
3D image and graph based Computation of Protein Surface
Authors: Ranganath Aruna , Shet K.C. , Vidyavathi N. 
Published: December 2017

Abstract The accessible surface of a macromolecule is a significant determinant of its action. The interaction between biomolecules or protein-ligand is dependent on their surfaces rather than their bulk properties. Identifying these local properties of bimolecular surfaces plays a vital role in the area of biomedicine. For example, identifying binding sites, docking etc. In this paper we describe an algorithm for computing the molecular surface of protein. The algorithm considers the 3D structure of the protein as a 3D image. The algorithm constructs a 3D graph corresponding to the size of 3D image data volume; the graph nodes correspond to image voxels.The idea is drawn from the cost minimization in a graph developed by Thedens and Fleagle[1]. The algorithm uses a Dynamic Programming Technique to avoid combinatorial explosion of the legal local surface.