bluuebunny/crossref_metadata_2025_split huggingface dataset:
The management of acute venous thromboembolism in clinical practice
Authors: Cohen Alexander T. , Gitt Anselm K. , Bauersachs Rupert , Fronk Eva-Maria , Laeis Petra , Mismetti Patrick , Monreal Manuel , Willich Stefan N. , Bramlage Peter , Agnelli Giancarlo ,   the PREFER in VTE Scientific Steering Committee and the PREFER in VTE Investigators
Published: April 2017

SummaryVenous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0% were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5%). The diagnosis was deep-vein thrombosis (DVT) in 59.5% and pulmonary embolism (PE) in 40.5%. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5%), hypertension (42.3%) and dyslipidaemia (21.1%). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2%), almost half received a vitamin K antagonist (48.7%) and nearly a quarter received a DOAC (24.5%). Almost a quarter of all presentations were for recurrent VTE, with >80% of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes.
A long-acting PAI-1 inhibitor reduces thrombus formation
Authors: Peng Shuangzhou , Xue Guangpu , Gong Lihu , Fang Chao , Chen Jingfei , Yuan Cai , Chen Zhuo , Yao Lishan , Furie Bruce , Huang Mingdong 
Published: April 2017

SummaryPlasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents thrombosis and accelerates fibrinolysis, indicating that PAI-1 inhibitors may be used as effective antithrombotic agents. We previously designed a PAI-1 inhibitor (PAItrap) which is a variant of inactivated urokinase protease domain. In the present study, we fused PAItrap with human serum albumin (HSA) to develop a long-acting PAI-1 inhibitor. Unfortunately, the fusion protein PAItrap-HSA lost some potency compared to PAItrap (33 nM vs 10 nM). Guided by computational method, we carried out further optimisation to enhance inhibitory potency for PAI-1. The new PAItrap, denominated PAItrap(H37R)-HSA, which was the H37R variant of PAItrap fused to HSA, gave a six-fold improvement of IC50 (5 nM) for human active PAI-1 compared to PAItrap-HSA, and showed much longer plasma half-life (200-fold) compared to PAItrap. We further demonstrated that the PAItrap(H37R)-HSA inhibited exogenous or endogenous PAI-1 to promote fibrinolysis in fibrin-clot lysis assay. PAItrap(H37R)-HSA inhibits murine PAI-1 with IC50 value of 12 nM, allowing the inhibitor to be evaluated in murine models. Using an intravital microscopy, we demonstrated that PAItrap(H37R)-HSA blocks thrombus formation and platelet accumulation in vivo in a laser-induced vascular injury mouse model. Additionally, mouse tail bleeding assay showed that PAItrap(H37R)-HSA did not affect the global haemostasis. These results suggest that PAItrap(H37R)-HSA have the potential benefit to prevent thrombosis and accelerates fibrinolysis.
Evaluation of Noah Frozen Soil Parameterization for Application to a Tibetan Meadow Ecosystem
Authors: Zheng Donghai , van der Velde Rogier , Su Zhongbo , Wen Jun , Wang Xin , Yang Kun 
Published: April 2017

Abstract
This study evaluates the Noah land surface model (LSM) in its ability to simulate water and heat exchanges over frozen ground in a Tibetan meadow ecosystem. A comprehensive dataset including in situ micrometeorological and soil moisture–temperature profile measurements collected between November and March is utilized, and analyses of the measurements reveal that the measured soil freezing characteristics are better captured by 1) modifying the parameter bl implemented in the current Noah LSM that constrains the shape parameter of soil water retention curve utilized by the water potential freezing point depression equation to produce appropriate liquid water content θliq under subzero temperature conditions and 2) neglecting the ice effect on soil-specific surface and thus matric potential via setting the empirical parameter that accounts for the effect of increase in specific surface of soil particles and ice–liquid water ck to zero. The numerical experiments performed with the Noah model run show that in comparison to the default Noah LSM, adoption of ck = 0 and site-specific bl values reduces the overestimation of θliq across the soil profile. Implementation of augmentations such as the parameterization of diurnally varying thermal roughness length resolves the overestimation of daytime turbulent heat fluxes and underestimation of surface temperature. Further adoption of a new heat conductivity parameterization reduces the overestimation of nighttime surface temperature. An appropriate treatment of phase change efficiency that accounts for changing freezing rate with varying liquid water contents is also needed to reduce the temperature underestimation across soil profiles.
Impacts of a Mesoscale Eddy Pair on Internal Solitary Waves in the Northern South China Sea revealed by Mooring Array Observations
Authors: Huang Xiaodong , Zhang Zhiwei , Zhang Xiaojiang , Qian Hongbao , Zhao Wei , Tian Jiwei 
Published: April 2017

AbstractBoth internal solitary waves (ISWs) and mesoscale eddies are ubiquitous in the northern South China Sea (SCS). In this study, the authors examine the impacts of mesoscale eddies on the ISWs transiting the northern SCS deep basin that evolve from the steepening internal tide generated in the Luzon Strait, using in situ data collected from a specifically designed mooring array. From November 2013 to January 2014, an energetic mesoscale eddy pair consisting of one anticyclonic eddy (AE) and one cyclonic eddy (CE) propagated across the mooring array. Observations revealed that the amplitude, propagation direction, and speed of the transbasin ISWs were significantly modulated by the eddy pair. When the moorings were covered by the southern portion of the AE, the ISW amplitudes decreased by as much as 67% because of the thermocline deepening along the wave direction and the energy divergence along the wave front. When the moorings were covered by the northern portions of both eddies, the amplitude of ISWs also decreased but to a relatively smaller degree. ISWs propagated the fastest inside the southern portion of the AE, where both the thermocline deepening and eddy currents enhanced the propagation speed of ISWs. Under the influence of the AE (CE) core, ISWs propagated more northward (southward) than usual. The observational results reported here highlight the importance of resolving mesoscale eddies in circulation–internal wave coupled models to accurately predict kinematic characteristics of ISWs.
Development and validation of a prediction algorithm for the onset of common mental disorders in a working population
Authors: Fernandez Ana , Salvador-Carulla Luis , Choi Isabella , Calvo Rafael , Harvey Samuel B , Glozier Nicholas 
Published: April 2017

Objective: Common mental disorders are the most common reason for long-term sickness absence in most developed countries. Prediction algorithms for the onset of common mental disorders may help target indicated work-based prevention interventions. We aimed to develop and validate a risk algorithm to predict the onset of common mental disorders at 12 months in a working population. Methods: We conducted a secondary analysis of the Household, Income and Labour Dynamics in Australia Survey, a longitudinal, nationally representative household panel in Australia. Data from the 6189 working participants who did not meet the criteria for a common mental disorders at baseline were non-randomly split into training and validation databases, based on state of residence. Common mental disorders were assessed with the mental component score of 36-Item Short Form Health Survey questionnaire (score ⩽45). Risk algorithms were constructed following recommendations made by the Transparent Reporting of a multivariable prediction model for Prevention Or Diagnosis statement. Results: Different risk factors were identified among women and men for the final risk algorithms. In the training data, the model for women had a C-index of 0.73 and effect size (Hedges’ g) of 0.91. In men, the C-index was 0.76 and the effect size was 1.06. In the validation data, the C-index was 0.66 for women and 0.73 for men, with positive predictive values of 0.28 and 0.26, respectively Conclusion: It is possible to develop an algorithm with good discrimination for the onset identifying overall and modifiable risks of common mental disorders among working men. Such models have the potential to change the way that prevention of common mental disorders at the workplace is conducted, but different models may be required for women.
Capture-Recapture: Using Existing Data Sources to Improve Perinatal Hepatitis B Surveillance, Philadelphia, 2008-2014
Authors: Kuncio Danica E. , Newbern E. Claire , Ma Liyuan , Madera Robbie , Barlow Bruce , Robison S. Ginny , Viner Kendra M. , Johnson Caroline C. 
Published: April 2017

Objective: The objective of this study was to describe the capture-recapture method used by the Philadelphia Department of Public Health to enhance surveillance of perinatal hepatitis B virus (HBV), report on results and limitations of the process, and determine why some HBV-positive mother-infant pairs were not initially identified by Philadelphia’s Perinatal Hepatitis B Prevention Program (PHBPP). Methods: We performed capture-recapture retrospectively for births in 2008 and 2009 in Philadelphia and prospectively for births from 2010 to 2014 by independently matching annual birth certificate data to PHBPP and HBV surveillance data. We compared the number of HBV-positive mother-infant pairs identified each year to the point estimates and lower-limit estimates calculated by the Centers for Disease Control and Prevention for the Philadelphia PHBPP. Results: Of 156 605 pregnancy outcomes identified between 2008 and 2014, we found 1549 HBV-positive mother-infant pairs. Of 705 pairs that were initially determined, 358 (50.7%) were confirmed to be previously unidentified HBV-positive pairs. Reasons for failing to identify these mother-infant pairs prior to capture-recapture included internal administrative issues (n = 191, 53.4%), HBV testing and reporting issues (n = 92, 25.7%), and being lost to follow-up (n = 75, 20.9%). Each year that capture-recapture was used, the number of pairs identified by the Philadelphia PHBPP exceeded the Centers for Disease Control and Prevention’s lower-limit estimates for HBV-positive mother-infant pairs. Conclusions: Capture-recapture was useful for identifying HBV-positive pregnant women for Philadelphia’s PHBPP and for highlighting inadequacies in health department protocols and HBV testing during pregnancy. Other health departments with access to similar data sources and staff members with the necessary technical skills can adapt this method.
Comparison of Gravity Flow Rates Between ENFit and Legacy Feeding Tubes
Authors: Mundi Manpreet S. , Duellman Wanda , Epp Lisa , Davidson Jacob , Hurt Ryan T. 
Published: April 2017

AbstractBackground: Misconnections between enteral supplies and other access devices have led to significant morbidity and mortality. To reduce misconnections, a standard small‐bore connector has been developed (International Organization for Standards 80369‐8; ENFit). The full impact of transition to this connector is not known, however. Method: Working with major manufacturers and Food and Drug Administration, we obtained ENFit and comparative legacy tubes of variable sizes (low‐profile, 14F, 18F, 20F, and 24F balloon gastrostomies). Gravity enteral feeding was simulated with an empty bolus syringe attached to the feeding tube to be tested. The tube was clamped and filled to the 60‐mL mark with liquid (water, Jevity 1 Cal, Isosource HN, Isosource 1.5 Cal, Two Cal HN, and Nourish). The clamp was released, and time for formula to leave the syringe was recorded. Results: There was no difference in flow rate between the aggregate legacy and ENFit tubes for the low‐profile, 18F, and 20F sizes. The ENFit 14F tubes had a lower flow rate vs the legacy tubes, largely due to the low flow rates seen with the 1 ENFit tube. Similarly, 24F ENFit tubes with some formulas yielded lower flow rates as opposed to legacy. Conclusion: Overall, for the low‐profile, 18F, and 20F sizes, the ENFit tubes had similar flow rates when compared with the legacy tubes. For the 14F and 24F sizes, the flow rate of ENFit tubes was significantly lower, which could result in longer EN delivery for patients who are using these tubes to provide gravity feeding.
Mechanochemical endovenous ablation of saphenous veins using the ClariVein: A systematic review
Authors: Witte Marianne E. , Zeebregts Clark J. , de Borst Gert Jan , Reijnen Michel M.P.J. , Boersma Doeke 
Published: April 2017

Objective To systematically review all available English literature on mechanochemical endovenous ablation and to report on the anatomical, technical, and clinical success. Methods A systematic literature search was performed in PubMed, EMBASE, and the Cochrane Library on mechanochemical endovenous ablation for the treatment of insufficient great and/or small saphenous vein. Methodological quality of the included studies was evaluated using the MINORS score. The primary outcome measure was anatomical success, defined as closure of the treated vein on follow-up duplex ultrasound imaging. Secondary outcomes were technical and clinical success, and major complications defined as deep venous thrombosis, pulmonary embolisms or paresthesia. Results The literature search identified 759 records, of which 13 were included, describing 10 unique cohorts. A total of 1521 veins (1267 great saphenous vein and 254 small saphenous vein) were included, with cohort sizes ranging from 30 to 570 veins. The pooled anatomical success rate after short-term follow up was 92% (95% CI 90–94%) ( n = 1314 veins). After 6 and 12 months these numbers were 92% (95% CI 88–95%) ( n = 284) and 91% (95% CI 86–94%) ( n = 228), respectively. The long-term anatomical success rates at 2 and 3 years were 91% (95% CI 85–95%) ( n = 136) and 87% (95% CI 75–94%) ( n = 48), respectively. Major complications and especially nerve injury were very rare (≤ 0.2%). All studies were of moderate or good quality using the MINORS scoring scale. Conclusions Mechanochemical endovenous ablation using the ClariVein in combination with liquid sclerosant is associated with an anatomical success rate ranging from 87% to 92% and good clinical success. To date, no randomized controlled trials are available studying the anatomical success after mechanochemical ablation, compared to the endothermal ablation. The risk of major complications is very low after the procedure.
Quantification of early cutaneous manifestations of chronic venous insufficiency by automated analysis of photographic images: Feasibility and technical considerations
Authors: Becker François , Fourgeau Patrice , Carpentier Patrick H. , Ouchène Amina 
Published: April 2017

Summary We postulate that blue telangiectasia and brownish pigmentation at ankle level, early markers of chronic venous insufficiency, can be quantified for longitudinal studies of chronic venous disease in Caucasian people. Objectives and methods To describe a photographic technique specially developed for this purpose. The pictures were acquired using a dedicated photo stand to position the foot in a reproducible way, with a normalized lighting and acquisition protocol. The image analysis was performed with a tool developed using algorithms optimized to detect and quantify blue telangiectasia and brownish pigmentation and their relative surface in the region of interest. To test the short-term reproducibility of the measures. Results The quantification of the blue telangiectasia and of the brownish pigmentation using an automated digital photo analysis is feasible. The short-term reproducibility is good for blue telangiectasia quantification. It is a less accurate for the brownish pigmentation. Conclusion The blue telangiectasia of the corona phlebectatica and the ankle flare can be assessed using a clinimetric approach based on the automated digital photo analysis.
Evaluation of reduced-dose CT for acute non-traumatic abdominal pain: evaluation of diagnostic accuracy in comparison to standard-dose CT
Authors: Othman Ahmed E , Bongers Malte Niklas , Zinsser Dominik , Schabel Christoph , Wichmann Julian L , Arshid Rami , Notohamiprodjo Mike , Nikolaou Konstantin , Bamberg Fabian 
Published: April 2017

Background Patients with acute non-traumatic abdominal pain often undergo abdominal computed tomography (CT). However, abdominal CT is associated with high radiation exposure. Purpose To evaluate diagnostic performance of a reduced-dose 100 kVp CT protocol with advanced modeled iterative reconstruction as compared to a linearly blended 120 kVp protocol for assessment of acute, non-traumatic abdominal pain. Material and Methods Two radiologists assessed 100 kVp and linearly blended 120 kVp series of 112 consecutive patients with acute non-traumatic pain (onset < 48 h) regarding image quality, noise, and artifacts on a five-point Likert scale. Both radiologists assessed both series for abdominal pathologies and for diagnostic confidence. Both 100 kVp and linearly blended 120 kVp series were quantitatively evaluated regarding radiation dose and image noise. Comparative statistics and diagnostic accuracy was calculated using receiver operating curve (ROC) statistics, with final clinical diagnosis/clinical follow-up as reference standard. Results Image quality was high for both series without detectable significant differences ( P = 0.157). Image noise and artifacts were rated low for both series but significantly higher for 100 kVp ( P ≤ 0.021). Diagnostic accuracy was high for both series (120 kVp: area under the curve [AUC] = 0.950, sensitivity = 0.958, specificity = 0.941; 100 kVp: AUC ≥ 0.910, sensitivity ≥ 0.937, specificity = 0.882; P ≥ 0.516) with almost perfect inter-rater agreement (Kappa = 0.939). Diagnostic confidence was high for both dose levels without significant differences (100 kVp 5, range 4–5; 120 kVp 5, range 3–5; P = 0.134). The 100 kVp series yielded 26.1% lower radiation dose compared with the 120 kVp series (5.72 ± 2.23 mSv versus 7.75 ± 3.02 mSv, P < 0.001). Image noise was significantly higher in reduced-dose CT (13.3 ± 2.4 HU versus 10.6 ± 2.1 HU; P < 0.001). Conclusion Reduced-dose abdominal CT using 100 kVp yields excellent image quality and high diagnostic accuracy for the assessment of acute non-traumatic abdominal pain.
Neuropathic orofacial pain: Facts and fiction
Authors: Baad-Hansen Lene , Benoliel Rafael 
Published: April 2017

Definition and taxonomyThis review deals with neuropathic pain of traumatic origin affecting the trigeminal nerve, i.e. painful post-traumatic trigeminal neuropathy (PTTN).SymptomatologyThe clinical characteristics of PTTN vary considerably, partly due to the type and extent of injury. Symptoms involve combinations of spontaneous and evoked pain and of positive and negative somatosensory signs. These patients are at risk of going through unnecessary dental/surgical procedures in the attempt to eradicate the cause of the pain, due to the fact that most dentists only rarely encounter PTTN.EpidemiologyOverall, approximately 3% of patients with trigeminal nerve injuries develop PTTN. Patients are most often female above the age of 45 years, and both physical and psychological comorbidities are common.PathophysiologyPTTN shares many pathophysiological mechanisms with other peripheral neuropathic pain conditions.Diagnostic considerationsPTTN may be confused with one of the regional neuralgias or other orofacial pain conditions. For intraoral PTTN, early stages are often misdiagnosed as odontogenic pain.Pain managementManagement of PTTN generally follows recommendations for peripheral neuropathic pain.Expert opinionInternational consensus on classification and taxonomy is urgently needed in order to advance the field related to this condition.
Diagnostic Efficacy of Serum Amyloid A Protein and Soluble Intercellular Adhesion Molecule 1 in Pediatric Ventilator-Associated Pneumonia
Authors: Abo-Hagar Hamdy H. , Abo-Elezz Ahmed Abd ElBasset , Mehrez Mostafa , Mabrouk Maaly M. , Elshora Ola A. 
Published: April 2017

Objectives: Study of inflammatory biomarkers which may aid in early detection of ventilator-associated pneumonia (VAP) in children and predicting their outcome. Patients: Thirty-five children, aged 2 months to 13 years, needed mechanical ventilation (MV) for more than 48 hours due to causes other than pneumonia. Methods: Measurement of serum amyloid A (SAA) protein, soluble intercellular adhesion molecule 1 (sICAM-1), and C-reactive protein (CRP), modified clinical pulmonary infection score (CPIS) and performing culture of endotracheal aspirate at the start and on the third day of MV. Results: Ventilator-associated pneumonia was diagnosed by CPIS in 6 (17.1%) of 35 patients. On the third day of MV, there was a significant increase in serum mean levels of SAA, sICAM-1, and CRP in comparison to the start of MV ( P = .005, .004, and .01, respectively). Three (50%) of 6 patients with VAP died, while 4 (14.28%) of 28 patients without VAP died. The sensitivity of serum SAA, sICAM-1, and CPIS were 100% for predicting VAP, while specificity was highest for CPIS (96.55%) followed by SAA (93.1%). Combination of CPIS and SAA increased the specificity to 100%. For predicting nonsurvival, serum SAA and sICAM-1 had a sensitivity of 100% and a specificity of 92.86% and 89.29%, respectively. Conclusion: Serum amyloid A and sICAM-1 may be considered as reliable markers for detection of VAP. Combination of serum SAA with CPIS increased the specificity to 100%. Measurement of SAA in patients with VAP also had a good predictive value for nonsurvival in such patients.