bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human resource factors associated with workplace safety and health education of small manufacturing businesses in Korea
Authors: Park Kyoung-Ok 
Published: October 2017

Abstract

Objectives
Human resources (HR) are essential indicators of safety and health (SH) status, and HR can be key sources of workplace safety management such as safety and health education at work (SHEW). This study analyzed significant HR factors associated with SHEW of small manufacturing businesses in Korea.

Methods
The secondary data of the 2012 Korea Occupational Safety and Health Trend Survey were used to achieve this research purpose. A total of 2,089 supervisors or managers employed in the small manufacturing businesses completed the interview survey. Survey businesses were selected by multiple stratified sampling method based on industry code, business size, and region in Korea. The survey included workplace characteristics of HR and SHEW.

Results
SHEW was significantly related to business size, occupational injury incidence in the previous year, foreign and elderly worker employment, presence of site supervisors, and presence of SH committees (p &lt;.05). SHEW for office workers, non-office workers, and newcomers was associated with business size, presence of site supervisors, and presence of SH committees in logistic regression analysis (p &lt; .001) . Businesses with 30-49 workers conducted SHEW 3.64 times more than did businesses with 5 to fewer than 10 workers. The companies that had occupational injuries in the previous year conducted SHEW 1.68 times more than the others. The businesses that had site supervisors and committees conducted SHEW 2.30 and 2.18 times more, respectively, than others.

Conclusions
Site supervisors and SH committees were significant HR factors that improved SHEW in small manufacturing businesses.
Comparison of brain connectivity between Internet gambling disorder and Internet gaming disorder: A preliminary study
Authors: Bae Sujin , Han Doug Hyun , Jung Jaebum , Nam Ki Chun , Renshaw Perry F. 
Published: October 2017

Background and aims
Given the similarities in clinical symptoms, Internet gaming disorder (IGD) is thought to be diagnostically similar to Internet-based gambling disorder (ibGD). However, cognitive enhancement and educational use of Internet gaming suggest that the two disorders derive from different neurobiological mechanisms. The goal of this study was to compare subjects with ibGD to those with IGD.

Methods
Fifteen patients with IGD, 14 patients with ibGD, and 15 healthy control subjects were included in this study. Resting-state functional magnetic resonance imaging data for all participants were acquired using a 3.0 Tesla MRI scanner (Philips, Eindhoven, The Netherlands). Seed-based analyses, the three brain networks of default mode, cognitive control, and reward circuitry, were performed.

Results
Both IGD and ibGD groups demonstrated decreased functional connectivity (FC) within the default-mode network (DMN) (family-wise error p < .001) compared with healthy control subjects. However, the IGD group demonstrated increased FC within the cognitive network compared with both the ibGD (p < .01) and healthy control groups (p < .01). In contrast, the ibGD group demonstrated increased FC within the reward circuitry compared with both IGD (p < .01) and healthy control subjects (p < .01).

Discussion and conclusions
The IGD and ibGD groups shared the characteristic of decreased FC in the DMN. However, the IGD group demonstrated increased FC within the cognitive network compared with both ibGD and healthy comparison groups.
Rare Tumor Clinic: The University of California San Diego Moores Cancer Center Experience with a Precision Therapy Approach
Authors: Kato Shumei , Kurasaki Kellie , Ikeda Sadakatsu , Kurzrock Razelle 
Published: October 2017

Abstract

Background
Patients with rare tumors may lack approved treatments and clinical trial access. Although each rare tumor is uncommon, cumulatively they account for approximately 25% of cancers. We recently initiated a Rare Tumor Clinic that emphasized a precision medicine strategy.

Materials and Methods
We investigated the first 40 patients presenting at the Rare Tumor Clinic. Next-generation sequencing (NGS) of tissue and plasma-derived, circulating-tumor DNA (ctDNA), and protein markers were assessed.

Results
Median age was 58 years (range, 31–78 years); 70% (28/40) were women; median number of previous systemic therapies was 2 (range 0–7). The most common diagnoses were sarcoma (n = 7) for solid tumors and Erdheim-Chester disease (n = 5) for hematologic malignancies. Twenty distinct diagnoses were seen. Examples of ultrarare tumors included ameloblastoma, yolk sac liver tumor, ampullary cancer, and Castleman's disease. Altogether, 32 of 33 patients (97%) with tissue NGS and 15 of 33 (45%) with ctDNA sequencing harbored ≥1 alteration. Overall, 92.5% of patients (37/40) had ≥1 actionable target based on either genomic (n = 32) or protein (n = 27) markers. In total, 52.5% (21/40) received matched therapy; 52.4% (11/21) achieved stable disease (SD) ≥6 months (n = 3), partial remission (PR; n = 6), or complete remission (CR; n = 2). Matched therapy resulted in significantly longer progression-free survival compared with last prior unmatched therapy (hazard ratio 0.26, 95% confidence interval 0.10–0.71, p = .008).

Conclusion
Identifying genomic and protein markers in patients with rare/ultrarare tumors was feasible. When therapies were matched, &gt;50% of patients attained SD ≥6 months, PR, or CR. Further precision medicine clinical investigations focusing on rare and ultrarare tumors are urgently needed.

Implications for Practice
Although rare tumors are infrequent by definition, when all subtypes of rare cancers are combined, they account for approximately 25% of adult malignancies. However, patients with rare tumors may lack approved treatments and clinical trial access. This paper describes an institutional a Rare Tumor Clinic focused on a precision medicine strategy. Performing genomics and protein analyses was feasible amongst patients with rare cancers. Over 50% of patients attained SD ≥6 months, PR, or CR when they received matched therapy (genomically targeted and/or immunotherapy). Further studies investigating the efficacy of the precision therapy approach among rare tumors are warranted.
Efficacy of Prophylactic Treatment for Oxycodone-Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo-Controlled, Double-Blind Trial
Authors: Tsukuura Hiroaki , Miyazaki Masayuki , Morita Tatsuya , Sugishita Mihoko , Kato Hiroshi , Murasaki Yuka , Gyawali Bishal , Kubo Yoko , Ando Masahiko , Kondo Masashi , Yamada Kiyofumi , Hasegawa Yoshinori , Ando Yuichi 
Published: October 2017

Abstract

Background
Although opioid-induced nausea and vomiting (OINV) often result in analgesic undertreatment in patients with cancer, no randomized controlled trials have evaluated the efficacy of prophylactic antiemetics for preventing OINV. We conducted this randomized, placebo-controlled, double-blind trial to evaluate the efficacy and safety of prophylactic treatment with prochlorperazine for preventing OINV.

Materials and Methods
Cancer patients who started to receive oral oxycodone were randomly assigned in a 1:1 ratio to receive either prochlorperazine 5 mg or placebo prophylactically, given three times daily for 5 days. The primary endpoint was the proportion of patients who had a complete response (CR) during the 120 hours of oxycodone treatment. CR was defined as no emetic episode and no use of rescue medication for nausea and vomiting during 5 days. Key secondary endpoints were the proportion of patients with emetic episodes, proportion of patients with moderate or severe nausea, quality of life, and proportion of treatment withdrawal.

Results
From November 2013 through February 2016, a total of 120 patients were assigned to receive prochlorperazine (n = 60) or placebo (n = 60). There was no significant difference in CR rates (69.5% vs. 63.3%; p = .47) or any secondary endpoint between the groups. Patients who received prochlorperazine were more likely to experience severe somnolence (p = .048).

Conclusion
Routine use of prochlorperazine as a prophylactic antiemetic at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetics would be effective in preventing OINV in specific patient populations.

Implications for Practice
Prophylactic prochlorperazine seems to be ineffective in preventing opioid-induced nausea and vomiting (OINV) and may cause adverse events such as somnolence. Routine use of prophylactic prochlorperazine at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetics would be effective in preventing OINV in specific patient populations.
The reasons of genetic heterogeneity of Siberian whitefish Coregonus lavaretus pidschian in the Anabar river
Authors: Sendek Dmitry S. , Ivanov Eugenie V. 
Published: October 2017

Background. A population genetic study of Siberian whitefish or pidschian Coregonus lavaretus pidschian Gmelin of the Anabar River (North-West Yakutia) has been done to study genetic structure of the species within a river system and for revealing its phylogeographic relations.
Materials and Methods. Five samples of pidschian from different parts of the river were analyzed for 30 isozyme loci.
Results and Discussion. The results has demonstrated a significant genetic heterogeneity of the species sampled from lower and middle reaches of the river (0.001 DN 0.056). The most likely reason for genetic differentiation of the species within the river system is a colonization of the watershed by independent phylogenetic lineages of whitefish. At present the phylogenetic lineages in Anabar River are presented by sympatric ecological forms of the species eastern-siberian whitefish and glacial-plains whitefish which maintain their reproductive isolation. The relationships of ecological forms of whitefish dwelling the Anabar River with other populations of the species in Siberia, and possible ways of penetration of discrete phylogenetic lineages of pidschian in the basin of studied river are discussed.
Conclusions. A genetic heterogeneity of whitefish from Anabar River should be taken into account while creating adequate intraspecific taxonomy and considered in conducting fisheries and environmental measures.
Legislación en enfermería: el sinuoso camino hacia la autonomía
Authors: Serdarevich Úrsula 
Published: October 2017

<p>La presente es una reflexión sobre el recorrido histórico de las leyes que regulan la enfermería como profesión, la diversificación de roles y las responsabilidades que pueden ser fuente de conflicto. También se ocupa de repensar las iniciativas destinadas a la captación del recurso humano enfermero. Para tal fin, se propone un análisis de la normativa profesional de enfermería en Argentina orientado a configurar competencias, alcances y grado de autonomía.</p><p> </p><p> </p>
Biomechanical Comparison of Single-Bundle and Double-Bundle Posterior Cruciate Ligament Reconstruction
Authors: Lee Dong-Yeong , Kim Dong-Hee , Kim Hyun-Jung , Nam Dae-Cheol , Park Jin-Sung , Hwang Sun-Chul 
Published: October 2017

Background:
Of the many issues regarding surgical techniques for posterior cruciate ligament (PCL) reconstruction, the choice between single-bundle (SB) and double-bundle (DB) reconstruction is one of the most debated. However, it is unclear which of the reconstruction techniques yields better outcomes in knees with a PCL injury. The purpose of this meta-analysis was to compare the benefits of SB and DB PCL reconstruction in terms of biomechanical outcomes.

Methods:
The MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and SCOPUS electronic databases were searched for relevant articles comparing the outcomes of SB and DB PCL reconstruction that were published up until August 2016. Data searching, extraction, analysis, and quality assessment were performed on the basis of the Cochrane Collaboration guidelines. Biomechanical outcomes of both techniques were evaluated using various outcomes. Results involving continuous outcomes are presented as standardized mean differences (SMDs) with 95% confidence intervals (CIs).

Results:
Ten biomechanical studies were included. There were no significant biomechanical differences between the groups with respect to external rotation, varus rotation, or coupled external rotation of the tibia with posterior drawer force at any knee flexion angle. However, posterior laxity measured using the posterior drawer test showed significantly better results after DB compared with SB reconstruction at low flexion (SMD = −0.90, 95% CI = −1.24 to −0.56, I2 = 0%), 30° (SMD = −0.79, 95% CI = −1.28 to −0.31, I2 = 48%), 60° (SMD = −0.87, 95% CI = −1.33 to −0.40, I2 = 33%), and 90° (SMD = −0.73, 95% CI = −1.11 to −0.35, I2 = 27%).

Conclusions:
Anatomic DB reconstruction of the PCL is superior to anatomic SB reconstruction in terms of restoration of anteroposterior stability. However, it remains unclear which technique yields better improvement in terms of external rotation laxity, varus laxity, and coupled external rotation of the tibia with posterior drawer force. High-quality randomized controlled trials are required to confirm and expand on these results.
Cartilage Restoration of the Patellofemoral Joint
Authors: Kane Patrick W. , Tucker Bradford S. , Frederick Robert , Ciccotti Michael G. , Freedman Kevin B. 
Published: October 2017

* Articular cartilage defects of the patellofemoral joint are a common source of pain in athletes as well as in the general population.* Consideration of different factors such as defect size and depth, patient age, and subchondral bone involvement is important in determining the best treatment option.* Recognition of the complex biomechanics of the patellofemoral joint is essential in ensuring positive outcomes when treating these lesions.
Investigation on In-Situ Combustion in D66, a Multilayered Heavy Oil Reservoir, Liaohe Oilfield
Authors: Teng L. , Song H. , Zhang S. , Wu F. , Xu D. , Gong Y. , Jiang Z. , Gao H. , Wang C. , Zhong L. 
Published: October 2017

Abstract
In-situ combustion (ISC) has been investigated worldwide as a potential EOR process both for heavy oil and conventional oil, and there are some successful field applications such as industrial test in Suplacu and many tests in deep reservoir with low permeability. Most of heavy oil reservoirs recovered by In-situ combustion are known for favor reservoir properties such as limited layers (single layer is best) and appropriate heavy oil viscosity (usually hundreds to thousands of mPa•s). Obviously, it is challenging to recover multilayered heavy oil reservoirs by in-situ combustion method in consideration of heterogeneity between layers. For instance, Du 66 reservoir is a typical multilayered heavy oil reservoir in Liaohe Oilfield, it was not effectively recovered by cyclic steam stimulation (CSS in short) before 2005, and both oil production and OSR were unsatisfactory. There are no alternative but to test in-situ combustion for the purpose of improve oil recovery for such multilayered heavy oil reservoir. As a result, there are up to 91 well groups operated in inverted nine-spot pattern fireflood combined with CCS for production wells in past 10 years.
In this work, feasibility analysis and engineering design of in-situ combustion for multilayered D66 reservoir are primarily investigated based on reservoir engineering study and numerical simulation. Furthermore, recovery performance such as air injection profile and gas production and channeling are discussed based on field measurement and performance. Particularly, principles and treatment of gas channeling and casing collapse are discussed. Additionally, both experience and lessons are presented based on statistical results and typical cases.
The results show that considerable increase in oil production and improvement in ratio of oil production to steam injection (OSR in short) are observed at lower ratio of air injection to oil production (AOR in short). However, gas channeling occurs in some production wells in form of rapid increase in AOR, and it has significant effect on production performance. At the same time, casing collapse are found in many air injection wells, according remedial well treatment had to be carried out considering risk of high temperature, backfire and even explosion, and casing collapse has a much greater impact on injection performance and oil recovery. Therefore, investigation on gas channeling and profile control treatment of air injection wells were extensively carried out to eliminate gas channeling and casing collapse.
In summary, the principles and engineering design of in-combustion in multilayered heavy oil reservoir are much more complex than single layer reservoir. Gas channeling and casing collapse are two extremely difficult problems in such combustion process, which could be eliminated or weakened based on rational engineering design and effective technologies.
Dissolvable Tools in Multistage Stimulation
Authors: Jin Ningjing , Zeng Qijun 
Published: October 2017

Abstract
Dissolvable tools have been introduced to the industry functioning mainly as temporary pressure bearing tools, which will dissolve themselves after operations of a planned duration to restore the original flow-path. This paper is intended to present two types of dissolvable tools; dissolvable plug and dissolvable frac ball that are used in multistage stimulations. Dissolvable bridge plugs and frac balls are now available, meaning there will be no need to drill out the bridge plug or frac balls. This is different than a composite bridge plug and can provide substantial savings in time reduction for every well. Dissolvable technology avoids any HSE issues related to plug milling/drilling. Under different temperature and salinity, the ROD (Rate of Dissolving) of dissolvable metal, Mg-Al alloy can be varied. Detailed tests, have been performed to establish a raw material selection chart based on conditions for various downhole applications. Lab tests on dissolvable tools to prove pressure rating and temperature rating. Field runs of dissolvable tools downhole have shown they hold high differential pressure, in agreement with the lab test 10K psi differential pressure rating. After the stimulation operation is concluded the dissolvable tools dissolve in a pre-designed duration downhole. We will discuss the novel experience gained from a China Shale Gas project from an operational perspective. The discussion will describe dissolvable tools raw material selection, the successful and economical dissolvable plug & perf operation that was conducted.
Project Specific Risk Consideration from a Portfolio Perspective
Authors: Allan Paul D. , D'Arcy Mark 
Published: October 2017

Abstract
While many companies utilize advanced systems for quantifying and normalizing geologic risks, and some have standardized above ground risk characterization, relatively few use this information effectively when assessing risks at a corporate portfolio or aggregate level. Detailed project assessments are often distilled into expected value representations when combined at a corporate level, leaving the company exposed to potential risk concentrations and aggregate performance variability. This paper demonstrates an approach to assessing value and risks at a portfolio level when the underlying components contain opportunity specific and potentially unique risk drivers. Identifying critical risks at the corporate portfolio level and translating this information into efficient data compilation requests and allocation decisions requires a structured and disciplined approach. While the techniques in describing geological and above ground risks at a project level are commonly applied and portfolio aggregations of projects are routinely conducted, the tripping point for many organizations is in effectively leveraging the detailed stochastic information at a portfolio level. Gaining insights at the aggregate level and maintaining the appropriate perspective on these uncertainties can yield significant value to organizations as they mitigate risks and adjust plans to exploit opportunities. Many of the techniques used to quantify ‘portfolio risk’, such as efficient frontier risk measures, multi-objective scoring, or combined approaches fail in terms of providing decision makers with tangible and practical guidance as to the real impact of specific decisions on objectives. This paper codifies an approach that makes it possible to align the degree of acceptable corporate level uncertainties (risk) with the underlying, project level descriptions. This basic methodology may be employed and expanded to a wide range of asset types and diverse portfolio sets, independent of company size or complexity. A portfolio model was constructed, with individual projects described with varying degrees of uncertainty detail. This provides a clear example of the methodology while demonstrating the relative importance of project specific uncertainties as these are translated into an aggregate corporate view. The simple analytic structure described in this paper may be scaled to represent much more complex uncertainty environments and more diverse assets as required. The value in properly capturing project specific uncertainties and maintaining these descriptions when assessing portfolio value and risks is quantified for the examples depicted.
New Development Method to Enhance Production Recovery on Mature Field - Success Story from Semberah Field, East Kalimantan, Indonesia
Authors: Kramadibrata A. T. , Permana R. C. 
Published: October 2017

AbstractSemberah field, located in East Kalimantan, has been explored since 1974 and developed in 1990. Peak production was reached in late 1998 at 180 MMscfd and 13,000 BOPD. Sharp production decline occurred since 2000 and the field rate dropped from 170 MMscfd to 25 MMscfd in 10 years. Several efforts have been made to sustain decline at economical rate by infill well drilling, horizontal well, and compression system optimization.Until 2008 drilling is mainly focused in middle area of Semberah along crestal area containing large reservoir tanks with updip position thus favoring high additional reserve and avoiding water table. The well population in south area was very dense with average interval 300 meters. In contrast, to the north crestal areas which have more down dip structure are less developed. The challenge of developing north area is due to limited data from existing wells and the possibility of hitting water reservoir. In 2008, a study was conducted to assess the possibility of applying semi-grid based drilling campaign in north area. The method was based on the combination of deltaic reservoir, new geological understanding and statistical study from previous drilling result. As pilot project, one well was drilling in north area with distance over 800 meters from offset well.The result was positive, the well encountered new reservoirs or pools with high gas deliverability. The semi-grid based drilling was then focused in north area with various distance 500 - 1000 meters. After 2 years, Semberah field rate increase from 25 MMscfd to 70 MMscfd. A cumulative of 18 BCF gas was produced until 2015 from new reservoirs. A methodology of optimizing well spacing in deltaic reservoir is studied and perfected. The most optimum well spacing to increase the possibility of getting new reservoirs in north area was 500 - 700 meters.This paper describes the successful implementation of integrated development strategy, which proved to be an effective process to enhance production recovery of a mature asset.