bluuebunny/crossref_metadata_2025_split huggingface dataset:
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis
Authors: Asano Yoshinori , Kawase Tatsuya , Okabe Atsushi , Tsutsumi Shuichi , Ichikawa Hitoshi , Tatebe Satoko , Kitabayashi Issay , Tashiro Fumio , Namiki Hideo , Kondo Tadashi , Semba Kentaro , Aburatani Hiroyuki , Taya Yoichi , Nakagama Hitoshi , Ohki Rieko 
Published: January 2016

AbstractThe transcription factors HSF1 and p53 both modulate the stress response, thereby protecting and facilitating the recovery of stressed cells, but both have the potential to promote tumor development. Here we show that a p53 target gene, IER5, encodes an activator of HSF1. IER5 forms a ternary complex with HSF1 and the phosphatase PP2A and promotes the dephosphorylation of HSF1 at numbers of serine and threonine residues, generating a novel, hypo-phosphorylated active form of HSF1. IER5 is also transcriptionally upregulated in various cancers, although this upregulation is not always p53-dependent. The IER5 locus is associated with a so-called super enhancer, frequently associated with hyperactivated oncogenes in cancer cell lines. Enhanced expression of IER5 induces abnormal HSF1 activation in cancer cells and contributes to the proliferation of these cells under stressed conditions. These results reveal the existence of a novel IER5-mediated cancer regulation pathway that is responsible for the activation of HSF1 observed in various cancers.
Micro/Nano hierarchical peony-like Al doped ZnO superhydrophobic film: The guiding effect of (100) preferred seed layer
Authors: Li Yang , Wang Jingfeng , Kong Yi , Zhou Jia , Wu Jinzhu , Wang Gang , Bi Hai , Wu Xiaohong , Qin Wei , Li Qingkun 
Published: January 2016

AbstractIn this communication, we present a versatile and controllable strategy for formation of superhydrophobic micro/nano hierarchical Al doped ZnO (AZO) films with a water contact angle (CA) of 170 ± 4°. This strategy involves a two-step layer-by-layer process employing an atomic layer deposition (ALD) technique followed by a hydrothermal method and the resulting novel AZO surface layer consists of (100) dominant nano-rice-like AZO seed layer (the water CA of 110 ± 4°) covered with micro-peony-like AZO top. The growth mechanisms and superhydrophobic properties of the hierarchical AZO layer are discussed. It is believed that the present route holds promise for future success in the design and development of practical superhydrophobic materials.
Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials
Authors: Serban Maria-Corina , Sahebkar Amirhossein , Mikhailidis Dimitri P. , Toth Peter P. , Jones Steven R. , Muntner Paul , Blaha Michael J. , Andrica Florina , Martin Seth S. , Borza Claudia , Lip Gregory Y. H. , Ray Kausik K. , Rysz Jacek , Hazen Stanley L. , Banach Maciej 
Published: January 2016

AbstractWe aimed to assess the impact of L-carnitine on plasma Lp(a) concentrations through systematic review and meta-analysis of available RCTs. The literature search included selected databases up to 31st January 2015. Meta-analysis was performed using fixed-effects or random-effect model according to I2 statistic. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI). The meta-analysis showed a significant reduction of Lp(a) levels following L-carnitine supplementation (WMD: −8.82 mg/dL, 95% CI: −10.09, −7.55, p < 0.001). When the studies were categorized according to the route of administration, a significant reduction in plasma Lp(a) concentration was observed with oral (WMD: −9.00 mg/dL, 95% CI: −10.29, −7.72, p < 0.001) but not intravenous L-carnitine (WMD: −2.91 mg/dL, 95% CI: −10.22, 4.41, p = 0.436). The results of the meta-regression analysis showed that the pooled estimate is independent of L-carnitine dose (slope: −0.30; 95% CI: −4.19, 3.59; p = 0.878) and duration of therapy (slope: 0.18; 95% CI: −0.22, 0.59; p = 0.374). In conclusion, the meta-analysis suggests a significant Lp(a) lowering by oral L-carnitine supplementation. Taking into account the limited number of available Lp(a)-targeted drugs, L-carnitine might be an effective alternative to effectively reduce Lp(a). Prospective outcome trials will be required to fully elucidate the clinical value and safety of oral L-carnitine supplementation.
Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity
Authors: León Silvia , Barroso Alexia , Vázquez María J. , García-Galiano David , Manfredi-Lozano María , Ruiz-Pino Francisco , Heras Violeta , Romero-Ruiz Antonio , Roa Juan , Schutz Günther , Kirilov Milen , Gaytan Francisco , Pinilla Leonor , Tena-Sempere Manuel 
Published: January 2016

AbstractKisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet, whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of their reproductive effects remains debatable. To dissect out direct vs. indirect effects of kisspeptins on GnRH neurons in vivo, we report herein the detailed reproductive/gonadotropic characterization of a Gpr54 null mouse line with selective re-introduction of Gpr54 expression only in GnRH cells (Gpr54−/−Tg; rescued). Despite preserved fertility, adult rescued mice displayed abnormalities in gonadal microstructure, with signs of precocious ageing in females and elevated LH levels with normal-to-low testosterone secretion in males. Gpr54−/−Tg rescued mice showed also altered gonadotropin responses to negative feedback withdrawal, while luteinizing hormone responses to various gonadotropic regulators were variably affected, with partially blunted relative (but not absolute) responses to kisspeptin-10, NMDA and the agonist of tachykinin receptors, NK2R. Our data confirm that direct effects of kisspeptins on GnRH cells are sufficient to attain fertility. Yet, such direct actions appear to be insufficient to completely preserve proper functionality of gonadotropic axis, suggesting a role of kisspeptin signaling outside GnRH cells.
Evidence of high-elevation amplification versus Arctic amplification
Authors: Wang Qixiang , Fan Xiaohui , Wang Mengben 
Published: January 2016

AbstractElevation-dependent warming in high-elevation regions and Arctic amplification are of tremendous interest to many scientists who are engaged in studies in climate change. Here, using annual mean temperatures from 2781 global stations for the 1961–2010 period, we find that the warming for the world’s high-elevation stations (>500 m above sea level) is clearly stronger than their low-elevation counterparts; and the high-elevation amplification consists of not only an altitudinal amplification but also a latitudinal amplification. The warming for the high-elevation stations is linearly proportional to the temperature lapse rates along altitudinal and latitudinal gradients, as a result of the functional shape of Stefan-Boltzmann law in both vertical and latitudinal directions. In contrast, neither altitudinal amplification nor latitudinal amplification is found within the Arctic region despite its greater warming than lower latitudes. Further analysis shows that the Arctic amplification is an integrated part of the latitudinal amplification trend for the low-elevation stations (≤500 m above sea level) across the entire low- to high-latitude Northern Hemisphere, also a result of the mathematical shape of Stefan-Boltzmann law but only in latitudinal direction.
Hierarchical Sheet-on-Sheet ZnIn2S4/g-C3N4 Heterostructure with Highly Efficient Photocatalytic H2 production Based on Photoinduced Interfacial Charge Transfer
Authors: Zhang Zhenyi , Liu Kuichao , Feng Zhiqing , Bao Yanan , Dong Bin 
Published: January 2016

AbstractWe have realized in-situ growth of ultrathin ZnIn2S4 nanosheets on the sheet-like g-C3N4 surfaces to construct a “sheet-on-sheet” hierarchical heterostructure. The as-synthesized ZnIn2S4/g-C3N4 heterojunction nanosheets exhibit remarkably enhancement on the photocatalytic activity for H2 production. This enhanced photoactivity is mainly attributed to the efficient interfacial transfer of photoinduced electrons and holes from g-C3N4 to ZnIn2S4 nanosheets, resulting in the decreased charge recombination on g-C3N4 nanosheets and the increased amount of photoinduced charge carriers in ZnIn2S4 nanosheets. Meanwhile, the increased surface-active-sites and extended light absorption of g-C3N4 nanosheets after the decoration of ZnIn2S4 nanosheets may also play a certain role for the enhancement of photocatalytic activity. Further investigations by the surface photovoltage spectroscopy and transient photoluminescence spectroscopy demonstrate that ZnIn2S4/g-C3N4 heterojunction nanosheets considerable boost the charge transfer efficiency, therefore improve the probability of photoinduced charge carriers to reach the photocatalysts surfaces for highly efficient H2 production.
Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells
Authors: Yamada Shuhei , Tsukamoto Shuntaro , Huang Yuhui , Makio Akiko , Kumazoe Motofumi , Yamashita Shuya , Tachibana Hirofumi 
Published: January 2016

AbstractMicroRNAs (miRNAs) are non-coding RNAs involved in various biological processes by regulating their target genes. Green tea polyphenol (−)-epigallocatechin-3-O-gallate (EGCG) inhibits melanoma tumor growth by activating 67-kDa laminin receptor (67LR) signaling. To examine the effect of EGCG on miRNA expression in melanoma cells, we performed miRNA microarray analysis. We showed that EGCG up-regulated miRNA-let-7b expression through 67LR in melanoma cells. The EGCG-induced up-regulation of let-7b led to down-regulation of high mobility group A2 (HMGA2), a target gene related to tumor progression. 67LR-dependent cAMP/protein kinase A (PKA)/protein phosphatase 2A (PP2A) signaling pathway activation was involved in the up-regulation of let-7b expression induced by EGCG. These findings provide a basis for understanding the mechanism of miRNA regulation by EGCG.
Evaluation of the 2b-RAD method for genomic selection in scallop breeding
Authors: Dou Jinzhuang , Li Xue , Fu Qiang , Jiao Wenqian , Li Yangping , Li Tianqi , Wang Yangfan , Hu Xiaoli , Wang Shi , Bao Zhenmin 
Published: January 2016

AbstractThe recently developed 2b-restriction site-associated DNA (2b-RAD) sequencing method provides a cost-effective and flexible genotyping platform for aquaculture species lacking sufficient genomic resources. Here, we evaluated the performance of this method in the genomic selection (GS) of Yesso scallop (Patinopecten yessoensis) through simulation and real data analyses using six statistical models. Our simulation analysis revealed that the prediction accuracies obtained using the 2b-RAD markers were slightly lower than those obtained using all polymorphic loci in the genome. Furthermore, a small subset of markers obtained from a reduced tag representation (RTR) library presented comparable performance to that obtained using all markers, making RTR be an attractive approach for GS purpose. Six GS models exhibited variable performance in prediction accuracy depending on the scenarios (e.g., heritability, sample size, population structure), but Bayes-alphabet and BLUP-based models generally outperformed other models. Finally, we performed the evaluation using an empirical dataset composed of 349 Yesso scallops that were derived from five families. The prediction accuracy for this empirical dataset could reach 0.4 based on optimal GS models. In summary, the genotyping flexibility and cost-effectiveness make 2b-RAD be an ideal genotyping platform for genomic selection in aquaculture breeding programs.
The Effects of Weather Factors on Hand, Foot and Mouth Disease in Beijing
Authors: Dong Weihua , Li Xian’en , Yang Peng , Liao Hua , Wang Xiaoli , Wang Quanyi 
Published: January 2016

AbstractThe morbidity and mortality of hand, foot and mouth disease (HFMD) are increasing in Beijing, China. Previous studies have indicated an association between incidents of HFMD and weather factors. However, the seasonal influence of these factors on the disease is not yet understood and their relationship with the enterovirus 71 (EV71) and Coxsackie virus A16 (CV-A16) viruses are not well documented. We analysed 84,502 HFMD cases from 2008 to 2011 in Beijing to explore the seasonal influence of weather factors (average temperature [AT], average relative humidity [ARH], total precipitation [TP] and average wind speed [AWS]) on incidents of HFMD by using a geographically weighted regression (GWR) model. The results indicated that weather factors differ significantly in their influence on HFMD depending on the season. AT had the greatest effect among the four weather factors and while the influence of AT and AWS was greater in the summer than in the winter, the influence of TP was positive in the summer and negative in the winter. ARH was negatively correlated with HFMD. Also, we observed more EV71-associated cases than CV-A16 but there is no convincing evidence to show significant differences between the influences of the weather factors on EV71 and CV-A16.
Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro
Authors: Tropea D , Molinos I , Petit E , Bellini S , Nagakura I , O'Tuathaigh C , Schorova L , Mitchell K J , Waddington J , Sur M , Gill M , Corvin A P 
Published: January 2016

AbstractMajor neuropsychiatric disorders are genetically complex but share overlapping etiology. Mice mutant for rare, highly penetrant risk variants can be useful in dissecting the molecular mechanisms involved. The gene disrupted in schizophrenia 1 (DISC1) has been associated with increased risk for neuropsychiatric conditions. Mice mutant for Disc1 display morphological, functional and behavioral deficits that are consistent with impairments observed across these disorders. Here we report that Disc1 L100P mutants are less able to reorganize cortical circuitry in response to stimulation in vivo. Molecular analysis reveals that the mutants have a reduced expression of PSD95 and pCREB in visual cortex and fail to adjust expression of such markers in response to altered stimulation. In vitro analysis shows that mutants have impaired functional reorganization of cortical neurons in response to selected forms of neuronal stimulation, but there is no altered basal expression of synaptic markers. These findings suggest that DISC1 has a critical role in the reorganization of cortical plasticity and that this phenotype becomes evident only under challenge, even at early postnatal stages. This result may represent an important etiological mechanism in the emergence of neuropsychiatric disorders.
Covert digital manipulation of vocal emotion alter speakers’ emotional states in a congruent direction
Authors: Aucouturier Jean-Julien , Johansson Petter , Hall Lars , Segnini Rodrigo , Mercadié Lolita , Watanabe Katsumi 
Published: January 2016

SignificanceWe created a digital audio platform to covertly modify the emotional tone of participants’ voices while they talked toward happiness, sadness, or fear. Independent listeners perceived the transformations as natural examples of emotional speech, but the participants remained unaware of the manipulation, indicating that we are not continuously monitoring our own emotional signals. Instead, as a consequence of listening to their altered voices, the emotional state of the participants changed in congruence with the emotion portrayed. This result is the first evidence, to our knowledge, of peripheral feedback on emotional experience in the auditory domain. This finding is of great significance, because the mechanisms behind the production of vocal emotion are virtually unknown.
Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia
Authors: Rozhok Andrii I. , Salstrom Jennifer L. , DeGregori James 
Published: January 2016

Significance
Elevated incidence of childhood leukemia relative to young adult ages is difficult to explain from the standpoint of oncogenic mutation accumulation. We applied a stochastic Monte Carlo model of hematopoietic stem cell (HSC) clonal dynamics based on published age-dependent parameters of HSCs. Our modeling results demonstrate that childhood and adult HSC clonal dynamics differ by the factors that determine the number of cell divisions per clonal context. Late in life, positive selection leading to clonal expansions increases the number of cell divisions per clone, whereas in childhood a similar increase is achieved by the much higher HSC division frequencies and drift-affected clonal expansions. We provide a mathematical argument that the obtained clonal dynamics and cell division measurements can explain the age-dependent incidence of leukemia.
Private algorithms for the protected in social network search
Authors: Kearns Michael , Roth Aaron , Wu Zhiwei Steven , Yaroslavtsev Grigory 
Published: January 2016

Significance
Motivated by tensions between data privacy for individual citizens, and societal priorities such as counterterrorism, we introduce a computational model that distinguishes between parties for whom privacy is explicitly protected, and those for whom it is not (the “targeted” subpopulation). Within this framework, we provide provably privacy-preserving algorithms for targeted search in social networks. We validate the utility of our algorithms with extensive computational experiments on two large-scale social network datasets.
Neotropical forest expansion during the last glacial period challenges refuge hypothesis
Authors: Leite Yuri L. R. , Costa Leonora P. , Loss Ana Carolina , Rocha Rita G. , Batalha-Filho Henrique , Bastos Alex C. , Quaresma Valéria S. , Fagundes Valéria , Paresque Roberta , Passamani Marcelo , Pardini Renata 
Published: January 2016

Significance
The tropical forests of South America are among the most diverse and unique habitats in the world in terms of plant and animal species. One of the most popular explanations for this diversity and endemism is the idea that forests retracted and fragmented during glacial periods, forming ecological refuges, surrounded by dry lands or savannas. These historically stable forest refuges would have been responsible for maintaining the pattern of diversity and endemism observed today. Here, we show that the Atlantic Forest of eastern South America probably expanded, rather than contracted, during the last glacial period. In addition, the emerged Brazilian continental shelf played a major, yet neglected, role on the evolution of this biodiversity hotspot during the last glacial period.
Nuclear TRAF3 is a negative regulator of CREB in B cells
Authors: Mambetsariev Nurbek , Lin Wai W. , Stunz Laura L. , Hanson Brett M. , Hildebrand Joanne M. , Bishop Gail A. 
Published: January 2016

SignificanceUniquely in B cells, deletion of the adaptor protein TRAF3 (TNF receptor-associated factor 3) causes enhanced survival; TRAF3 deficiency is observed in a substantial percentage of human B-cell malignancies. Here, we report that TRAF3 is a resident nuclear protein in B cells that regulates stability of the CREB (cAMP response element binding protein) transcription factor. This regulation is important for restraining B-cell survival by preventing transcription of prosurvival genes and may be a key mechanism by which loss of TRAF3 contributes to B-cell malignancies. Considering the high frequency ofTRAF3mutations in B-cell tumors, our findings of an important nuclear role for TRAF3 present a new paradigm in understanding both normal regulation of B-cell survival and pathogenesis of B-cell cancers.
Molecular mechanism of viomycin inhibition of peptide elongation in bacteria
Authors: Holm Mikael , Borg Anneli , Ehrenberg Måns , Sanyal Suparna 
Published: January 2016

Significance
Antibiotics are widely used to treat bacterial infections, but their mechanisms of action are often poorly understood. Viomycin is a tuberactinomycin antibiotic used for treating multidrug-resistant tuberculosis. Using an in vitro translation system that displays kinetic rates comparable to those in living cells we have characterized the mechanism of action of viomycin and constructed a kinetic model for how viomycin inhibits the translocation step of the peptide elongation cycle. Our results are vital for understanding the mechanism of the antimicrobial activity of viomycin and its sister drugs in living bacteria as well as resistance mechanisms against them, which can have strong implications for global health.
Close relation between quantum interference in molecular conductance and diradical existence
Authors: Tsuji Yuta , Hoffmann Roald , Strange Mikkel , Solomon Gemma C. 
Published: January 2016

Significance
It might seem that the existence of a dramatic diminution in molecular conductance across a hydrocarbon (quantum interference, QI) would be unrelated to the existence of an important class of organic molecules with two electrons in two orbitals, diradicals. However, if you add two carbons to a planar π-electron hydrocarbon, you get a diradical if and only if there is a QI feature in conductance when two electrodes are attached to the molecule at the same sites. When you remove the two carbons where the electrodes are attached, you also generate a diradical. The connection, first empirically observed, is proven. Two kinds of diradicals, with different ground state spin consequences, are also easily distinguished by the relationship.
Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions
Authors: Lee Young il , Li Yue , Mikesh Michelle , Smith Ian , Nave Klaus-Armin , Schwab Markus H. , Thompson Wesley J. 
Published: January 2016

SignificanceRefinement of synaptic connections occurs throughout the nervous system and is essential for its proper function. Significant gaps remain in our understanding of the mechanisms that mediate pruning of synaptic connections—a form of synaptic plasticity known as synapse elimination. Recently it has become clear there is significant glial cell involvement. The present study of the rodent neuromuscular junction addresses two outstanding questions involving this glial involvement: which molecules determine the Schwann cell behavior present during pruning, and whether these behaviors actually alter synaptic structure. Our findings identify axon-tethered neuregulin1 as a molecular determinant for Schwann cell-driven neuromuscular synaptic plasticity.
Origin of the
p
-process radionuclides
92
Nb and
146
Sm in the early solar system and inferences on the birth of the Sun
Authors: Lugaro Maria , Pignatari Marco , Ott Ulrich , Zuber Kai , Travaglio Claudia , Gyürky György , Fülöp Zsolt 
Published: January 2016

Significance
Radioactive nuclei with half-lives of the order of millions of years were present in the solar system at its birth and can be used as clocks to measure the events that predated the birth of the Sun. Two of these nuclei are heavy and rich in protons and can be produced only by particular chains of nuclear reactions during some supernova explosions. We have used their abundances to derive that at least 10 million years passed between the last of these explosions and the birth of the Sun. This means that the region where the Sun was born must have lived at least as long, which is possible only if it was very massive.