bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperacute thrombosis of a vertebral artery stent with a single missed dose of a P2Y12 inhibitor and poor stent wall apposition: illustrative case
Authors: Fang Misa , Koneru Manisha , Oliveira Renato , Santucci Joshua , Patel Pratit , Khalife Jane , Shaikh Hamza A , Tonetti Daniel A 
Published: October 2024

BACKGROUND
Iatrogenic vertebral artery injury during surgery can cause pseudoaneurysm, hemorrhage, thrombosis, ischemia, or death. Strategies to prevent cerebrovascular embolic complications include surgical ligation, endovascular stenting, and/or antiplatelet therapy.

OBSERVATIONS
A 73-year-old female with a known right vertebral artery occlusion underwent a C2–3 laminectomy, complicated by left vertebral artery injury and occlusion with subsequent posterior circulation ischemia. She underwent immediate angioplasty and stenting of the injured artery with undersized drug-eluting stents. Dual antiplatelet therapy of aspirin 81 mg daily and ticagrelor 90 mg twice daily was initiated. On two occasions, more than 6 months after stenting, holding a single ticagrelor dose led to in-stent thrombosis and embolic stroke within hours of the missed dose. Lifelong therapy with ticagrelor was favored over further procedural intervention.

LESSONS
It is recommended to prioritize optimal wall stent apposition with oversized stents in patients without collateral circulation. The risk of thromboembolism due to poorly apposed stents is very high, even in delayed (> 6 months) settings. Stent construct revision or bypass grafting may not be feasible or desirable options. For patients without wall apposition, endothelialization may not occur, necessitating lifelong P2Y12 inhibitor therapy to prevent recurrent thromboembolic events.
https://thejns.org/doi/10.3171/CASE24296
Construction of English corpus oral instant translation model based on information security and deep learning
Authors: Jiang Yuqing 
Published: October 2024

In order to improve the quality of translation, avoid translation ambiguity and accurately present the content of the source language, supported by the concept of deep learning and guaranteed by information security, an instant oral translation model is constructed for English corpus. The aim of this study is to enhance the efficiency and accuracy of oral translation systems through the application of deep learning algorithms. Specifically, we employ a sample training mechanism tailored to the unique characteristics of oral translation, allowing for separate training of system interaction and translation data. Furthermore, by redesigning the interaction hardware, this research comprehensively redefines the hardware structure of the translation system, marking a significant step towards improving the usability and performance of such systems. After obtaining and processing effective security sensitive information, language resources are managed by using database management system, which fundamentally improves the level of network information security. The performance of the existing oral automatic translation system (Test Group 1) and the system designed in this paper (Test Group 2) is tested by experiments, and the results are as follows: (1) The translation system designed here has better interactive performance, and it is better than Test Group 1. (2) The adaptive index value of Test Group 1 is 1, and that of Test Group 2 is 0.5, which proves that the adaptive ability of system algorithm of Test Group 2 is better than that of Test Group 1. (3) When comparing the translation speed, the translation time of Test Group 2 is only 70.7 s, while that of Test Group 1 is 130.6 s, so the proposed translation system is obviously superior to that of Test Group 1.
Systematically Challenging Three Prevailing Notions About Entropy and Life
Authors: Chen Jiming , Chen Ji-Wang , Zivieri Roberto 
Published: October 2024

This article reveals the original, fundamental, and uncontroversial nature of entropy and systematically challenges three notions prevailing in diverse disciplines: (1) Entropy is a measure of disorder; (2) life relies on negative entropy; (3) many systems tend to become increasingly disordered due to the second law of thermodynamics. The challenge is supported by numerous compelling facts and the modern explanation of the second law of thermodynamics. The challenge, if widely accepted, could facilitate the eradication of the entrenched misleading effects of the three misconceptions in diverse disciplines and facilitate relevant research and education on complexity, entropy, disorder, order, evolution, life, and thermodynamics.
Comparison of perception indicators of the gaming chatbot with puzzles tasks for teaching programming with perception indicators of other educational tools
Authors: Varnavsky A. N. 
Published: October 2024

Digital Game-Based Learning (DGBL) can be very effective. However, not all digital educational tools are equally effective in different learning situations, for learners of various backgrounds and various disciplines.The aim of the article is to compare the attractiveness, complexity and perceived usefulness of a gaming chatbot with puzzle tasks designed to teach programming with the same indicators of other educational tools.To conduct the study, a gaming chatbot with puzzle tasks, working in individual and team modes, a computer game, as well as a non-gaming chatbot for preparing for seminars and testing were developed and used in the process of teaching programming. The 1st year bachelor’s students of the educational program “Information Security” of the Faculty of Information Technology and Big Data Analysis at the Financial University under the Government of the Russian Federation used these digital educational tools and then evaluated their attractiveness, complexity, and usefulness.Several conclusions were drawn from the study. First, the use of game mechanics and the gaming chatbot with puzzles tasks significantly increases interest in the educational tool, so gaming chatbot has advantages over games and non-gaming chatbots. Second, the attractiveness evaluation of the gaming chatbot exceeded the corresponding evaluation of workshops. Both individual and team modes of gaming chatbot proved to be equally interesting, useful, and challenging for students. Consequently, the gaming chatbot can be used outside the classroom as well as in classroom activities. Third, if different types of gaming chatbot tasks, including those related to writing program code, are incorporated into the gaming chatbot, it will increase the usefulness of the chatbot.The results of the study contribute to the development of digital game-based learning using chatbots, particularly in teaching informatics and programming, and can help to increase the attractiveness of workshops and student engagement in general. The findings may be of practical interest to informatics and programming teachers.
Estimating the Prevalence of Primary Hypothyroidism in Karbala City, and Modulation of Clinical Manifestations Among Patients Receiving Levothyroxine; A Single Center Study
Authors: Zainab Hussien Ali  , Manal Khalid Abdulridha  , Qusay Baqer Alzajaji  
Published: October 2024

الخلاصة
قصور الغدة الدرقية لديه مجموعة واسعة من المظاهر السريرية والأعراض العامة، بما في ذلك على سبيل المثال لا الحصر السمنة، والتعب، وضعف التركيز، والاكتئاب، وألم العضلات على نطاق واسع، واضطرابات الدورة الشهرية، والإمساك. يعد تناول جرعة يومية من ليفوثيروكسين كافيًا للإدارة الناجحة لقصور الغدة الدرقية، لأنه يسهل استعادة مستويات TSH في الدم إلى نطاقها الطبيعي. هناك عدة عوامل يمكن أن تؤثر على امتصاص ليفوثيروكسين في جسم الإنسان، بما في ذلك العمر والوزن ووجود مشاكل طبية أخرى، والمدخول الغذائي . كان الهدف من هذه الدراسة هو تقييم مدى انتشار قصور الغدة الدرقية الأولي والتغيير في العرض السريري المرتبط بالعلاج البديل.
الطريقة: كانت هذه دراسة رصدية مقطعية أجريت في مركز الحسن للأيض والغدد الصماء والسكري (HMEDC). أكمل (111) مريضا البحث. قام فريق الدراسة بإنشاء استبيان. تم جمع البيانات من المقابلات وجها لوجه مع المرضى. تشمل البيانات التي تم جمعها من المرضى متغيرات اجتماعية ديموغرافية مختلفة، مستويات الفرتين والهرمون المحفز للغدة الدرقية في الدم ، والتفاعلات الدوائية، بالإضافة إلى العلامات والأعراض التي ظهرت قبل العلاج وبعده. بالإضافة إلى ذلك، يتم أيضًا تسجيل نظام علاج المريض والجرعات المحددة من الليفوثيروكسين التي يتم تناولها.
النتائج: بلغ إجمالي عدد الحالات التي زارت مركز الحسن للتمثيل الغذائي والغدد الصماء والسكري (HMEDC) خلال فترة الدراسة 10800 حالة. وكان معدل انتشار أمراض الغدة الدرقية 300 حالة (2.8٪). وبلغت نسبة قصور الغدة الدرقية الأولي من إجمالي عدد حالات قصور الغدة الدرقية 85.1%.(61%) من المرضى لديهم مستويات طبيعية من هرمون TSH بينما (42%) من المرضى وجد أنهم يحتاجون زيادة جرع الليفوثيروكسين. أظهر ما مجموعه (84٪) من المرضى مستويات طبيعية من الفيريتين. أظهر المرضى انخفاضًا في علاماتهم وأعراضهم بعد تناول العلاج.
االاستنتاج: أدى العلاج بالليفوثيروكسين إلى تحسين الكلام البطيء والإمساك وقلة الشهية والحساسية للبرد وزيادة الوزن والإرهاق. لا توجد علاقة ملحوظة بين جرعة ليفوثيروكسين وظهور العلامات والأعراض.
الكلمات المفتاحية :قصور الغدة الدرقية الأولي,الليفوثيروكسين
Pengaruh Response Time Ambulance terhadap Keberhasilan Penanganan Pasien out of Hospitals Cardiac Arrest (OHCA)
Authors: Irmajidain Ifani Nurul , Risnawati Risnawati 
Published: October 2024

ABSTRACT Ambulance response time determines the level of success in achieving the golden period in out-of-hospital cardiac arrest patients where the faster the medical staff provides quality first aid, the lower the patient's mortality rate. The purpose of this study was to determine the effect of ambulance response time on the success of handling out-of-hospital cardiac arrest patients. Quantitative research design The number of samples used in this study was 18 respondents using accidental samples. The instruments used in this study were observation sheets and questionnaires. In this study, the results were obtained, namely from 12 people who received an ambulance response time <15 minutes, 11 patients (55.5%) survived and 1 patient died. Meanwhile, from 6 people who received a slow ambulance response time >15 minutes, 1 patient (5.5%) survived and 5 patients (27.8%) died. The results of the Man Whitney statistical test obtained p value = 0.002 (p value <0.05) The conclusion is that there is an influence between ambulance response time in handling cardiac arrest. Fast and responsive response time from medical staff and ambulances is needed in handling OHCA patients. Keywords: Response Time, Out of Hospital Cardiac Arrest (OHCA), Ambulance ABSTRAK Waktu tanggap ambulans menentukan tingkat keberhasilan dalam mencapai periode emas untuk pasien henti jantung di luar rumah sakit, di mana semakin cepat petugas medis memberikan penanganan pertama yang berkualitas, maka semakin rendah tingkat kematian pasien. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh waktu tanggap ambulans terhadap keberhasilan penanganan pasien henti jantung di luar rumah sakit. Desain penelitian kuantitatif Jumlah sampel yang digunakan dalam penelitian ini adalah 18 responden dengan menggunakan accidental sampling. Instrumen yang digunakan dalam penelitian ini adalah lembar observasi dan kuesioner. Pada penelitian ini didapatkan hasil bahwa dari 12 orang yang mendapatkan waktu tanggap ambulans <15 menit, 11 pasien (55,5%) selamat dan 1 pasien meninggal dunia. Sedangkan dari 6 orang yang mendapatkan waktu tanggap ambulans lambat >15 menit, 1 orang (5,5%) selamat dan 5 orang (27,8%) meninggal dunia. Hasil uji statistik Man Whitney didapatkan nilai p = 0,002 (p value < 0,05). Kesimpulannya adalah terdapat pengaruh antara waktu tanggap ambulans dalam penanganan henti jantung. Respon time yang cepat dan tanggap dari tenaga medis dan ambulans sangat dibutuhkan dalam penanganan pasien OHCA. Kata Kunci: Waktu Tanggap, Henti Jantung Di Luar Rumah Sakit (OHCA), Ambulans
Pengaruh Pola Asuh Orang Tua terhadap Kejadian Stunting Pada Balita di Desa Pong Murung
Authors: Centis Maria Conchita Leyla , Trisnawati Reineldis E. , Dewi Imelda Rosniyati , Bandur Paskalinda M.Y 
Published: October 2024

ABSTRACT Stunting is one of the nutritional problems that is being addressed. Stunting has negative impact on growth and development in toddlers so that it must be resolved immediately must be resolved immediately. The cause of stunting in toddlers is malnutrition for a long period of time a long period of time. Many factors influence the incidence of stuntingone of which is parenting. Parenting patterns are closely related with the fulfillment of child nutrition, for example preparing food and also in providing stimulus to children. providing stimulus to children. To determine the effect of parenting patterns on the incidence of stunting in toddlers. The method used is quantitative with a cross sectional approach. The sample in the study amounted to 79 toddlers. Statistical test used is chi square. The results showed that there was an influence of parenting patterns on the incidence of stunting in toddlers with a p value of 0.03 <0.05. on the incidence of stunting in toddlers with a p value of 0.03 <0.05. Parenting patterns parenting plays an important role in determining the nutritional status of a toddler. So that so that the parenting pattern applied is good parenting, the growth and development of toddlers is more optimal development of toddlers is more optimal Keywords: Parenting, Stunting, Toddlers ABSTRAK Stunting merupakan salah satu masalah gizi yang sedang diatasi. Stunting memberikan dampak yang negatif bagi pertumbuhan dan perkembang pada balita sehingga harus segara diatasi. Penyebab kejadian stunting pada balita adalah kurang gizi dalam jangka waktu yang cukup lama. Banyak factor yang mempengaruhi kejadian stunting salah sarunya adalah pola asuh orangtua. Pola asuh orang tua berhubungan erat dengan pemenuhan gizi anak yaitu misalnya menyiapkan makanan dan juga dalam memberikan stimulus kepada anak. Untuk mengetahui pengaruh pola asuh orangtua terhadap kejadian stunting pada balita. Metode yang digunakan adalah kuantitatif dengan pendekatan cross sectional. Sampel dalam penelitian berjumlah 79 balita. Uji statistic yang digunakan adalah chi square. Hasil penelitian menunjukkan bahwa ada pengaruh pola asuh orangtua terhadap kejadian stunting pada balita dengan nilai p valuae 0,03 < 0,05. Pola asuh orang tua berperan penting dalam menentukan status gizi seorang balita. Sehingga pola asuh yang diterapkan adalah pola asuh yang baik maka pertumbuhan dan perkembangan balita lebih optimal Kata Kunci: Pola Asuh, Stunting, Balita
Pengetahuan Mampu Meningkatkan Pemberian ASI Eksklusif pada Bayi di Pustu Golodukal
Authors: Madur Junita P. , Kurniati Kornelia , Murti Nelviani 
Published: October 2024

ABSTRACT Indonesia's exclusive breastfeeding coverage in 2022 was recorded at only 67.96%, down from 69.7% in 2021, indicating the need for more intensive support so that this coverage can increase. Not providing breast milk contributes to infant mortality due to poor nutritional status which affects the baby's health and survival. To determine the effect of knowledge on exclusive breastfeeding for 0-6 months in the Pustu Golodukal working area. This research is quantitative descriptive with a cross-sectional approach. Samples were taken using total sampling technique with a total of 28 people. The statistical test used was chi-square with the measuring tool for data collection being the questionnaire. Most mothers with good knowledge categories were able to provide exclusive breastfeeding to their babies from 0-6 months. Statistical tests prove the results of the p-value = 0.008. There is an influence between the mother's knowledge of the baby's behavior on exclusive breastfeeding for babies 0-6 months at Pustu Golodukal. Keywords: Breastfeeding Mothers, Knowledge, Exclusive Breastfeeding ABSTRAK Cakupan ASI ekslusif Indonesia pada 2022 tercatat hanya 67,96%, turun dari 69,7% dari 2021, menandakan perlunya dukungan lebih intensif agar cakupan ini bisa meningkat. Tidak memberikan ASI menyumbang angka kematian bayi karena buruknya status gizi yang berpengaruh pada kesehatan bayi dan kelangsungan hidup bayi. Untuk mengetahui pengaruh pengetahuan terhadap pemberian ASI eksklusif 0-6 bulan diwilayah kerja Pustu Golodukal. Penelitian ini adalah deskriptif kuantitatif dengan pendekatan secara cross. Sampel diambil dengan tehnik Total sampling dengan jumlah 28 orang. Uji statistic yang digunakan menggunakan chi-square dengan alat ukur untuk pengumpulan data adalah kuiosner. Ibu dengan kategori pengetahuan yang baik Sebagian besar mampu memberikan asi eksklusif pada bayinya dari 0-6 bulan. uji statistic membuktikan hasil nilai p-value= 0,008. Ada pengaruh antara pengetahuan ibu bayi terhadap perilaku pemberian ASI eksklusif bayi 0-6 bulan di Pustu Golodukal. Kata Kunci: Ibu Menyusui, Pengetahuan, Pemberian ASI Eksklusif
Analisis Pelaksanaan Program Keselamatan Pasien IGD di RS Vina Estetika Medan
Authors: Zebua Arianus , Bangun Herianto 
Published: October 2024

ABSTRACT Patient safety is defined as a service that aims not to injure and harm patients or as a system in which hospitals make patient care safer. The target of compliance with patient identification correctly, effective communication with SBAR procedures, compliance by officers in maintaining hand hygiene, and compliance with identification of patients at risk of falling are still below 100%. The purpose of this study is to analyze the Implementation of the Emergency Room Patient Safety Program at the Vina Aesthetic Hospital Medan in 2021. This type of research is using descriptive descriptive with naturalistic nature. The data obtained through interviews with several main informants and additional informants, namely ER patients with the Triangulation method, can be concluded: Input (HR, every nurse or implementer in the ER has carried out patient safety well), Process (Patient Safety has been carried out in accordance with SOPs by applying maximum patient identification), Output (ER patient, feels that the identification has been carried out properly). The conclusion in this study is that the implementation of patient safety in the emergency room has been carried out following the patient safety SOP as much as possible. Keywords: Patient Safety, Nurse, Hospital ABSTRAK Keselamatan pasien (patient safety) didefinisikan sebagai layanan yang bertujuan untuk tidak menciderai dan merugikan pasien ataupun sebagai suatu sistem yang dimana rumah sakit membuat asuhan pasien lebih aman. Sasaran kepatuhan identifikasi pasien secara benar, komunikasi efektif dengan prosedur SBAR, kepatuhan petugas dalam menjaga kebersihan tangan, dan kepatuhan identifikasi pasien yang beresiko jatuh pencapaiannya masih berada dibawah 100%. Adapun tujuan dalam penelitian ini yaitu menganalisis Pelaksanaan Program Keselamatan Pasien IGD di RS Vina Estetika Medan Tahun 2021. Jenis penelitian ini yaitu menggunakan kalitatif deskrftif dengan sifat naturalistik. Data diperoleh melalui wawancara beberapa informan utama dan informan tambahan yaitu pasien IGD dengan metode Triangulasi dapat disimpulkan: Input (SDM, setiap perawat atau pelaksana di IGD sudah melakukan pelaksanaan keselamatan pasien dengan baik), Process (Keselamatan Pasien yang sudah dilakukan dengan sesuai SOP dengan menerapkan identifikasi pasien secara maksimal), Output (Pasien Ruang IGD, merasa sudah dilakukan identifikasi dengan baik). Keseimpulan dalam penelitian ini bahwa pelaksanaan safety patient di ruang IGD sudah terlaksana mengikuti SOP keselamatan pasien semaksimal mungkin. Kata Kunci: Keselamatan Pasien, Perawat, Rumah Sakit
Mekanisme Molekuler Pemanfaatan Wolbachia terhadap Virus Dengue
Authors: Nugraha Gita Rahmania 
Published: October 2024

ABSTRACT The incidence of dengue fever has increased drastically worldwide in recent decades. The increase in dengue fever shows that disease control programs are ineffective, new alternatives are needed. Wolbachia is used as a new alternative. This research aims to understand how the use of Wolbachia can influence the development of the dengue virus molecularly. This is a type of descriptive research with a qualitative approach. The research design is based on a systematic review study by collecting relevant journals indexed by Sinta and Google Scholar. The research results show that genetic manipulation of mosquitoes using Wolbachia bacteria can cause a decrease in virus copies and RNA copies with the mosquito's ability to block virus replication, all of which is related to cytoplasmic incompatibility. Wolbachia bacteria show potential as DENV biocontrol agents. This endosymbiotic bacteria, if integrated into the Aedes aegypti population, can reduce the ability of mosquitoes to spread the dengue fever virus. A comparison of four dengue fever isolates shows differences in the amount of RNA translated which affects the envelope protein E on the use of Wolbachia bacterial cells. Further studies are needed regarding the ratio of bases in RNA in dengue fever viruses. Keywords: Aedes aegypti, Dengue, Wolbachia ABSTRAK Insiden demam berdarah telah meningkat secara drastis di seluruh dunia dalam beberapa dekade terakhir. Meningkatnya penyakit demam berdarah menunjukkan bahwa program pengendalian penyakit tidak efektif, diperlukan alternatif baru. Wolbachia digunakan sebagai alternatif baru. Penelitian ini bertujuan untuk memahami bagaimana pemanfaatan Wolbachia dapat mempengaruhi perkembangan virus dengue secara molekuler. Merupakan jenis penelitian deskriptif dengan pendekatan kualitatif. Desain penelitian didasarkan pada studi systematic review dengan mengumpulkan jurnal - jurnal yang relevan terindeks Sinta dan Google Scholar. Hasil penelitian menunjukkan bahwa manipulasi genetik nyamuk menggunakan bakteri Wolbachia dapat menyebabkan penurunan salinan virus dan RNA copy dengan kemampuan nyamuk dalam memblokir replikasi virus yang mana semuanya berkaitan dengan ketidakcocokan sitoplasma. Bakteri Wolbachia menunjukkan potensi sebagai agen biokontrol DENV. Bakteri endosimbiotik ini jika diintegrasikan ke dalam populasi Aedes aegypti dapat menurunkan kemampuan nyamuk dalam menyebarkan virus demam berdarah. Dari perbandingan empat isolat demam berdarah menunjukan perbedaan jumlah RNA yang ditranslasikan sehingga mempengaruhi envelope protein E terhadap penggunaan sel bakteri Wolbachia. Diperlukan pengkajian lebih lanjut mengenai perbandingan basa di RNA pada virus demam berdarah. Kata Kunci: Aedes Aegypt, Dengue, Wolbachia