bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified local Granger causality analysis based on Peter‐Clark algorithm for multivariate time series prediction on IoT data
Authors: Lv Fei , Si Shuaizong , Xiao Xing , Ren Weijie 
Published: October 2024

AbstractClimate data collected through Internet of Things (IoT) devices often contain high‐dimensional, nonlinear, and auto‐correlated characteristics, and general causality analysis methods obtain quantitative causality analysis results between variables based on conditional independence tests or Granger causality, and so forth. However, it is difficult to capture dynamic properties between variables of temporal distribution, which can obtain information that cannot be obtained by the mean detection method. Therefore, this paper proposed a new causality analysis method based on Peter‐Clark (PC) algorithm and modified local Granger causality (MLGC) analysis method, called PC‐MLGC, to reveal the causal relationships between variables and explore the dynamic properties on temporal distribution. First, the PC algorithm is applied to compute the relevant variables of each variable. Then, the results obtained in the previous stage are fed into the modified local Granger causality analysis model to explore causalities between variables. Finally, combined with the quantitative causality analysis results, the dynamic characteristic curves between variables can be obtained, and the accuracy of the causal relationship between variables can be further verified. The effectiveness of the proposed method is further demonstrated by comparing it with standard Granger causality analysis and a two‐stage causal network learning method on one benchmark dataset and two real‐world datasets.
Rx for Legal Troubles: CEO Medical Degree and Corporate Litigation
Authors: Unsal Omer 
Published: October 2024

ABSTRACTResearch Question/IssueThis study examines the relationship between CEOs' medical degrees (MDs) and corporate litigations targeting US pharmaceutical firms.Research Findings/InsightsCEOs with a medical background are significantly more susceptible to securities class actions, while facing fewer patent lawsuits. The results indicate that the lack of management skills among MD CEOs comes at the cost of firm value. After lawsuit announcements, companies led by MD CEOs experience a significantly negative effect on their stock prices. Markets show no tolerance for failures by MD CEOs, as evidenced by the impact of clinical trial disappointments.Theoretical/Academic ImplicationsThe findings contribute to our understanding of the impact of CEOs' medical backgrounds on corporate litigation outcomes. The results suggest that when examining how a CEO's qualifications affect legal issues and the value of a company, we should consider the unique context of having an MD.Practitioner/Policy ImplicationsPractically, the study implies that firms should carefully consider the balance of managerial and medical expertise in CEO appointments, recognizing the potential legal and financial consequences. Policymakers might see it as beneficial to encourage a mix of different skills among top executives. This could make pharmaceutical companies more resilient in the face of legal issues, which, in turn, helps maintain confidence among investors.
Cesarean Section Is a Risk Factor That Prevents Organ Transplantation by Increasing the Development of Anti‐HLA Antibodies in Women
Authors: Akyüz Gökhan , Doğan Hasan 
Published: October 2024

ABSTRACTBackgroundIn this study, prenatal and postnatal blood samples were taken from pregnant women who had 35 or more gestational weeks and had not developed anti‐HLA positivity yet. The aim of this study was to evaluate the factors that may be effective in the development of panel reactive antibody (PRA) positivity during pregnancy.MethodsPRA testing was studied by taking the blood of 86 pregnant women 1 month before birth. Blood was taken again 1 month after birth from these women with prenatal PRA negative and it was checked whether PRA positivity developed. As a control group, 40 women without pregnancy were selected for the study.ResultsOf the 86 pregnant, 42 (48.8%) had cesarean sections, 44 (51.2%) had normal births, and PRA positivity developed in 14 (32.5%) of cesarean deliveries and three (8.0%) of normal births. In the control group, there were three (7.5%) PRA positivity. A statistically significant difference was found between cesarean delivery, normal delivery, and control group. Moreover, when compared with the control group, it was found statistically significant that all deliveries increased the development of HLA Class II antibodies.DiscussionCesarean delivery was associated with increased PRA positivity compared to normal birth. The new information presented in this study will pave the way for further research and enable healthcare professionals to consider both the individual's potential future need for organ transplantation and the positive impact on public health and more effective management of healthcare costs when making decisions regarding cesarean section.
New South Wales alcohol and other drug service providers' perceptions of the relative importance of client variables for determining treatment need
Authors: Larance Briony , Ingram Isabella , Haynes Chloe , Buckfield Lexi , Goh Choon Wee Melvin , Kelly Peter J. 
Published: October 2024

AbstractIntroductionThis study examines alcohol and other drug (AOD) service providers' perceptions of the most important variables (client complexity and demographic) for determining treatment need and intensity of intervention.MethodsOnline cross‐sectional survey of N = 188 clinicians/service managers working in AOD services across metropolitan and regional/rural New South Wales, Australia. Participants ranked the importance of demographic and family factors, substance use, physical health, mental health, functioning and activities of daily living and youth‐specific variables in identifying treatment need (five‐point Likert scales).ResultsMore than 90% of participants ranked 43 out 56 potential variables as ‘very important’/‘essential’ in identifying treatment need. The 10 variables most ranked as ‘very important’/‘essential’ were ‘pregnant or breastfeeding’ (95.2%), ‘suicide/self‐harm’ (95.2%), ‘overdose risk’ (94.7%), ‘abuse/neglect’ (among youth/adolescent populations; 94.1%), ‘mental health severity’ (93.6%), ‘dependent children’ (93.1%), ‘co‐existing mental health concerns’ (93.0%), ‘hospitalisations due to mental health’ (92.5%), ‘child protection concerns’ (among youth/adolescent populations; 92.2%) and ‘disability’ (91.5%). The 10 variables most commonly ranked as ‘slightly important’/‘not at all important’ included ‘citizenship’ (63.3%), ‘sex’ (59.6%), ‘country of birth’ (54.8%), ‘highest education’ (50.0%), ‘sexual orientation’ (44.1%), ‘relationship status’ (33.5%), ‘gender’ (31.4%), ‘transport’ (28.2%), ‘employment’ (23.9%) and ‘refugee status’ (24.0%). Some ratings differed by geographic location (metropolitan vs. regional/rural) and job role (allied health worker, nurse, doctor or manager).Discussion and ConclusionsThis study provides insight into service providers' perceptions of treatment need and intensity associated with a range of client factors. It is a first step towards improvements in routine data collections that are used to inform treatment planning.
How Infants Link Nonce Phrases to Scenes With Objects and Predicates
Authors: Buerkin‐Pontrelli Angelica , Swingley Daniel 
Published: October 2024

ABSTRACTWhen infants hear sentences containing unfamiliar words, are some language‐world links (such as noun–object) more readily formed than others (verb–predicate)? We examined English learning 14–15‐month‐olds’ capacity for linking referents in scenes with bisyllabic nonce utterances. Each of the two syllables referred either to the object's identity, or the object's motion. Infants heard the syllables in either a Verb–Subject (VS) or Subject–Verb (SV) order. Learning was tested using preferential looking. The results showed that infants learned the nouns and verbs equally well. In addition, in both the VS‐ and SV‐consistent conditions, infants learned the meaning of the utterance‐final syllable, but not the utterance‐initial one. A follow‐up experiment that manipulated the prosodic cues of the test phrases confirmed that infants had decomposed the bisyllabic phrases into two distinct word‐units. Thus, any biases potentially favoring noun or verb learning played a smaller role than utterance position did when noun and verb learning were equally supported by context.
Financial inclusion, financial stability, and poverty reduction in Africa
Authors: Tweneboah George , Nsiah Anthony Y. 
Published: October 2024

AbstractFinancial inclusion universally remains one of the critical means to end poverty in the world, especially Africa, where the level of poverty is high. It has however been argued that financial inclusion equally has the tendency to destabilize the financial system, thwarting the poverty reduction efforts, which necessitates the interrogation of the relationship between the variables. This study therefore investigates how financial stability mediates the financial inclusion and poverty reduction relationship in Africa. Using the panel Autoregressive Distributive Lag model, covering a period of 2004–2020, the study found that financial inclusion is positively related to financial stability in both short and long‐run, with education, Gross National Income per capita (GNI) and domestic credit to private sector, contributing to financial stability, and trade openness negatively related to financial stability in the long‐run. The study further established that financial stability is positively related to household consumption expenditure as such leads to poverty reduction with trade openness, government expenditure, GNI, education, domestic credit to private sector, and institutional quality contributing significantly to poverty reduction. This confirms the mediating role financial stability plays in enhancing the impact of financial inclusion on poverty reduction in Africa and must therefore be given the necessary attention, through proper regulatory mechanisms.
Characteristics of Individuals Losing Autism Diagnosis: A Comparative Study With Typically Developing and Autism Spectrum Disorder Individuals
Authors: Sevin Ilayda Barankoglu , Dogan Nurhak , Ozbaran Nazli Burcu 
Published: October 2024

ABSTRACTAimThis study aims to reveal the characteristics of individuals who have lost an autism spectrum disorder (ASD) diagnosis and to evaluate their current psychiatric diagnoses. Additionally, the study aims to compare individuals who have lost ASD with typically developing (TD) individuals and those with ASD in terms of current psychopathology, functionality and sociodemographic and clinical variables.MethodsThe study included a total of 85 participants aged between 5 and 18, comprising 30 individuals who no longer meet the criteria for ASD (loss of autism diagnosis or LAD), 32 individuals with ASD and 23 TD individuals. While the sociodemographic data form and Childhood Autism Rating Scale (CARS) were completed by the clinician, the Autism Behavior Checklist (ABC) and Social Responsiveness Scale (SRS) were completed by the parents.ResultsIt was found that the LAD group acquired speaking skills earlier, started special education sooner, received preschool education and physical exercise support for a longer duration and exhibited higher mental capacity and lower symptom severity compared to the ASD group. Moreover, 80% of the LAD group had at least one DSM‐5 diagnosis. Scores on the ABC and SRS indicated a significant difference, with ASD > LAD > TD.ConclusionsEven if ASD regresses, individuals may still experience residual difficulties and remain at risk for other psychopathologies. Therefore, it is crucial to maintain monitoring and support processes.
Equine nonproliferative pododermatitis of the frog (thrush): A review
Authors: O'Grady S. E. , Burns T. D. 
Published: October 2024

SummaryThrush is the term commonly used to describe nonproliferative pododermatitis of the frog epidermis caused by a bacterial infection. Thrush is commonly encountered in veterinary and farrier practices yet information on the pathogenesis, treatment and prevention of the disease in the equine veterinary literature is lacking. There is a plethora of proposed products and treatments on the market for thrush, yet most lack clinical evidence of efficacy. Clinical signs of thrush can range from black exudate in the sulci of the frog accompanied by a foul odour to bacterial invasion of the frog corium and digital cushion resulting in lameness. Thrush is primarily encountered in a conformationally compromised hoof capsule that is generally associated with an unhealthy frog. As thrush is rarely encountered in a healthy frog, it is important to focus on the farrier practices that may play a role in both the pathogenesis of thrush and its prevention. For successful treatment and prevention of thrush, good basic farrier principles must be incorporated into the treatment protocol.
Osseous pathologic changes in the thoracic region of the equine vertebral column: A descriptive post‐mortem study in three breeds
Authors: Spoormakers Tijn J. P. , Veraa Stefanie , Graat Elisabeth A. M. , van Weeren P. René , Brommer Harold 
Published: October 2024

AbstractBackgroundData on equine thoracic pathology hardly exist in breeds other than Thoroughbreds.ObjectivesTo describe pathological changes of the osseous thoracic vertebral column in Warmblood horses, Shetland ponies and Konik horses, and to compare prevalence and severity.Study designDescriptive post‐mortem study.MethodsComputed tomography was used to examine the thoracic vertebral column of 34 Warmblood horses, 28 Shetland ponies, and 18 Konik horses. Osteoarthritis (OA), periarticular osteolysis, osseous cyst‐like lesions and fragments of articular processes (APJs), costovertebral and costotransverse joints, soft tissue mineralisation surrounding these joints, intervertebral disc (IVD) mineralisation, impingement of spinous processes (SPs) and spondylosis were scored.ResultsAPJ aplasia (98%; 58/59) occurred in 14 Shetland ponies. OA predominated in Warmblood horses across all joints (45% vs. 29 and 32%, p < 0.001). OA and periarticular osteolysis were found in particular in the costotransverse joints (p < 0.001) across all breeds. Warmblood and Konik horses had more and severe soft tissue mineralisation than Shetland ponies (2.3%, score 1.5 and 3.2%, score 1.3, respectively, vs. 0.3%, score 0.9, p < 0.01). Mid location was most often affected with highest severity score (4.2%, 1.5, p < 0.001). Konik horses displayed the highest IVD mineralisation (20%, p < 0.001), which notably increased with age (p < 0.001) compared with Warmblood horses (4.5%) and Shetland ponies (1.1%). SPs impingement was absent in Shetland ponies, and most prevalent in Warmblood horses (11.2%, p < 0.001) compared with Konik horses (2.2%). Osseous cyst‐like lesions, fragments and spondylosis were minimal in all breeds and nearly absent in Shetland ponies.Main limitationsClinical histories and macroscopic and histologic examinations were unavailable.ConclusionsDistinct breed differences exist in prevalence and severity of thoracic vertebral column osseous pathologies. Costotransverse joint pathology is more common than APJ pathology in all breeds. Warmblood horses are prone to OA, spondylosis and SPs impingement; Konik horses exhibit significant IVD mineralisation, and Shetland ponies demonstrate a high prevalence of APJ aplasia. Periarticular osteolysis, osseous cyst‐like lesions, fragments and soft tissue mineralisation are notably low in Shetland ponies.
Transcriptomic analysis of genes associated with vitamin D receptor signalling reveals differences between skin cancers
Authors: Ocanha‐Xavier Juliana Polizel , Xavier‐Junior José Cândido Caldeira , Miot Hélio Amante , da Silva Márcia Guimarães , Marques Mariângela Esther Alencar 
Published: October 2024

AbstractVitamin D activates the vitamin D receptor (VDR), which dimerizes preferentially with the retinoid X receptor‐α (RXRα). This heterodimer connects with genetic elements responsive to vitamin D, inhibiting or stimulating gene activity. We performed Nanostring® analysis of VDR/RXRα to compare the mRNA expression of this heterodimer and their correlated transcriptomes in non‐melanoma skin cancer (basal cell carcinomas (BCC) and squamous cell carcinomas (SCC)) and melanocytic lesions (intradermal nevi (IN), and melanomas (MM)) with control skin. To evaluate VDR, RXRα and other 22 correlated genes in BCC, SCC, IN and MM, paraffin samples had their transcriptomes analysed using Nanostring®, a platform that allows multiple mRNA analyses. There were 46 samples, including 11 BCC, 10 SCC, 10 IN, 12 MM and 3 pools of control skins. Most mRNAs differed between the lesion groups and the control group. BCC and SCC NCOR2 were upregulated; in MM and IN, RXRγ was higher than in the control group. TP53, FOXO3 and MED1 showed a significant difference when we compared the BCC group to the SCC group. Melanoma and intradermal nevi differed only in AhR. VDR and RXRα were lower than the control in all groups. The panel shows a clear difference between the non‐melanocytic cancers and, on the other hand, a slight difference between the melanocytic lesions. The study of vitamin D's influence through its receptor and RXRα is an exciting issue for understanding the importance of this pathway, and the present study can impact the prevention and treatment strategies, mainly in non‐melanocytic tumours.
Bias mitigation for fair automation of classification tasks
Authors: Consuegra‐Ayala Juan Pablo , Gutiérrez Yoan , Almeida‐Cruz Yudivian , Palomar Manuel 
Published: October 2024

AbstractThe incorporation of machine learning algorithms into high‐risk decision‐making tasks has raised some alarms in the scientific community. Research shows that machine learning‐based technologies can contain biases that cause unfair decisions for certain population groups. The fundamental danger of ignoring this problem is that machine learning methods can not only reflect the biases present in our society but could also amplify them. This article presents the design and validation of a technology to assist the fair automation of classification problems. In essence, the proposal is based on taking advantage of the intermediate solutions generated during the resolution of classification problems through using Auto‐ML tools, in particular, AutoGOAL, to create unbiased/fair classifiers. The technology employs a multi‐objective optimization search to find the collection of models with the best trade‐offs between performance and fairness. To solve the optimization problem, we introduce a combination of Probabilistic Grammatical Evolution Search and NSGA‐II. The technology was evaluated using the Adult dataset from the UCI repository, a common benchmark in related research. Results were compared with other published results in scenarios with single and multiple fairness definitions. Our experiments demonstrate the technology's ability to automate classification tasks while incorporating fairness constraints. Additionally, our method achieves competitive results against other bias mitigation techniques. A notable advantage of our approach is its minimal requirement for machine learning expertise, thanks to its Auto‐ML foundation. This makes the technology accessible and valuable for advancing fairness in machine learning applications. The source code is available online for the research community.
University Actors Responding to the National Quality Assurance Regime for Higher Education in Malawi: A Case of Instrumentality, Pragmatism and Symbolic Compliance
Authors: Chikazinga Wanangwa W. N. 
Published: October 2024

ABSTRACTThe literature shows that the question of how to integrate quality assurance into higher education institutions is associated with several obstacles including non‐support from university actors. This study explored the university actors' response to the recently implemented external quality assurance and accreditation regime for higher education in Malawi. The findings showed that university actors respond to external quality assurance in divergent ways, mainly characterised by formal instrumentality, professional pragmatism and symbolic compliance. This meant that it would be naïve for external quality assurance agencies to assume that when university actors participate in external accreditation processes, it means that they embrace external quality assurance as a mechanism for enhancing quality. The implication was that national policy makers and quality assurance agencies should not consider university actors as ‘passive recipients’ that mutely accept quality assurance reforms, but rather seriously attend to them as both ‘makers’ and ‘shapers’ of policy in order to develop quality assurance systems that can be genuinely embraced. The study contributes to research that take a critical perspective in interpreting university personnel response to quality assurance.
Effect of pressure on the sintering mechanisms of tantalum carbide ceramics
Authors: Gu Junfeng , Ma Peiyan , Wang Hao , Wang Weimin , Fu Zhengyi 
Published: October 2024

AbstractHigh pressure sintering shows great superiority in promoting the densification of the hard‐to‐densify refractory ceramics, and the underlying mechanisms are thus of great interest. In the present work, the densification process of tantalum carbide (TaC) ceramics affected by pressure was discussed through comparing the microstructural characteristics and sintering kinetics. The TaC ceramics sintered at 30–250 MPa show dense and uniform microstructure without oxide impurities and high‐density dislocations. With the increase of sintering pressure, particle rearrangement becomes prominent at initial stage, whereas grain boundary diffusion rather than lattice diffusion dominants the final stage mechanism. Grain growth is enhanced under high pressure through the plastic deformation process. Our work should facilitate to understand the mass transport mechanisms during the high pressure sintering or deformation process of carbide ceramics.
Environmental Just Wars: Jus ad Bellum and the Natural Environment
Authors: Meisels Tamar 
Published: October 2024

ABSTRACTWar is bad for the environment, yet the environmental ramifications of warfare have not been widely addressed by just war theorists and revisionist philosophers of war. The law and legal scholars have paid more attention to protecting nature during armed conflict. But because the law focuses invariably on rules mitigating the conduct of hostilities rather than on objective justice of cause, environmental jus ad bellum has been explored even less extensively than environmental ethics in war. Setting out with the presumption against the use of force and its exceptions, this article considers whether environmental harm can trigger a new justification for war, at whose behest, and what might be a proportionate response to aggressive or negligent harm to nature. Force is clearly justified against military attacks. Where environmental harm is not caused by military aggression, proportionality points towards a response short of war. Full‐scale warfare will likely be counterproductive in protecting nature. This is less true if war is fought by drones destroying specific targets, or by cyber‐war, or by alternatives (or supplements) to war such as boycotts, ‘lawfare’, and ‘information/media warfare’. Responding in ways that minimize harm to nature also helps demonstrate ‘right intention’.