bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation and evaluation of endophytic Streptomyces endusOsiSh‐2 with potential application for biocontrol of rice blast disease
Authors: Xu Ting , Li Yan , Zeng Xiadong , Yang Xiaolu , Yang Yuanzhu , Yuan Shanshan , Hu Xiaochun , Zeng Jiarui , Wang Zhenzhen , Liu Qian , Liu Yuqing , Liao Hongdong , Tong Chunyi , Liu Xuanming , Zhu Yonghua 
Published: June 2016

AbstractBACKGROUNDBiocontrol is a promising strategy in the control of rice blast disease. In the present study, we isolated and characterized a novel antagonist to the pathogen Magnaporthe oryzae from rice endophytic actinomycetes.RESULTSOut of 482 endophytic actinomycetes isolated from rice blast infected and healthy rice, Streptomyces endus OsiSh‐2 exhibited remarkable in vitro antagonistic activity. Scanning electron microscopy observations of M. oryzae treated by OsiSh‐2 revealed significant morphological alterations in hyphae. In 2‐year field tests, the spraying of OsiSh‐2 spore solution (107 spores mL−1) is capable of reducing rice blast disease severity by 59.64%. In addition, a fermentation broth of OsiSh‐2 and its cell‐free filtrates could inhibit the growth of M. oryzae, suggesting the presence of active enzymes and secondary metabolites. OsiSh‐2 tested positive for polyketide synthase‐I and nonribosomal peptide synthetase genes and can produce cellulase, protease, gelatinase, siderophore, indole‐3‐acetic acid and 1‐amino‐cyclopropane‐1‐carboxylate deaminase. A preliminary separation indicated that the methanol extract of OsiSh‐2 could suppress the growth of pathogens. The major active component was identified as nigericin.CONCLUSIONEndophytic S. endus OsiSh‐2 has potential as a biocontrol agent against rice blast in agriculture. © 2016 Society of Chemical Industry
Genotypic character relationship and phenotypic path coefficient analysis in chili pepper genotypes grown under tropical condition
Authors: Usman Magaji G , Rafii Mohd Y , Martini Mohammad Y , Oladosu Yusuff , Kashiani Pedram 
Published: June 2016

AbstractBACKGROUNDStudies on genotypic and phenotypic correlations among characters of crop plants are useful in planning, evaluating and setting selection criteria for the desired characters in a breeding program. The present study aimed to estimate the phenotypic correlation coefficients among yield and yield attributed characters and to work out the direct and indirect effects of yield‐related characters on yield per plant using path coefficient analysis. Twenty‐six genotypes of chili pepper were laid out in a randomized complete block design with three replications.RESULTSYield per plant showed positive and highly significant (P ≤ 0.01) correlations with most of the characters studied at both the phenotypic and genotypic levels. By contrast, disease incidence and days to flowering showed a significant negative association with yield. Fruit weight and number of fruits exerted positive direct effect on yield and also had a positive and significant (P ≤ 0.01) correlation with yield per plant. However, fruit length showed a low negative direct effect with a strong and positive indirect effect through fruit weight on yield and had a positive and significant association with yield.CONCLUSIONLonger fruits, heavy fruits and a high number of fruits are variables that are related to higher yields of chili pepper under tropical conditions and hence could be used as a reliable indicator in indirect selection for yield. © 2016 Society of Chemical Industry
Laryngeal chondrosarcoma: A systematic review of 592 cases
Authors: Chin Oliver Y. , Dubal Pariket M. , Sheikh Ahmed B. , Unsal Aykut A. , Park Richard Chan Woo , Baredes Soly , Eloy Jean Anderson 
Published: June 2016

Objectives/HypothesisLaryngeal chondrosarcomas are rare entities that arise from the cartilaginous structures of the larynx, including the cricoid, thyroid cartilage, epiglottis, and arytenoid cartilages. These tumors represent a minority of malignancies involving the larynx and can be mistaken for benign pathologies. The treatment has historically been surgical excision, often by total laryngectomy. This review investigates treatment modalities and patient outcomes.Study DesignSystematic review using PubMed/MEDLINE and EMBASE database.MethodsThe databases were used to identify articles reporting cases of chondrosarcomas occurring exclusively in the larynx. Variables analyzed included patient demographics, presenting symptoms, grade, therapeutic approach, patient outcomes, and follow‐up.ResultsFive hundred and ninety‐two cases were identified. The average age reported was 62.5 years. There was a 3:1 male to female ratio. The most common surgical approach was local excision in 178 cases, followed by total laryngectomy in 174 cases. Nonsurgical treatment such as radiotherapy and chemotherapy was only used in 0.8% and 0.2%, respectively. Disease‐specific survival rates for 1, 5, 10, and 20 years were 97.7%, 91.4%, 81.8%, and 68.0%, respectively, with no differences when comparing 5‐year survival rates for location, grade, and therapy.ConclusionLaryngeal chondrosarcomas are rare with a good prognosis. Various surgical approaches exist, with no difference noted in 5‐year survival outcomes. Nonsurgical approaches were rarely used for these lesions.Level of EvidenceN/A. Laryngoscope, 2016 127:430–439, 2017
Synthesis of Chiral Oligomer‐Grafted Biodegradable Polyurethanes and Their Chiral‐Dependent Influence on Bone Marrow Stem Cell Behaviors
Authors: Hu Bin , Deng Jun , Zheng Honghao , Yu Shan , Gao Changyou 
Published: June 2016

Chirality is one of the most fascinating and ubiquitous features in nature, especially in biological systems. The effects of chiral surfaces, especially in combination with degradable materials of good biocompatibility, on stem cell behaviors has not yet been tackled. In this communication, the chiral monomers N‐acryloyl‐l(d)‐valine (l(d)‐AV) are synthesized and are polymerized to obtain chiral (l(d)‐PAV‐SH) oligomers, which are covalently immobilized onto electron‐deficient poly(propylene fumarate) polyurethane (PPFU) via Michael addition. The PPFU‐l‐PAV can interact more strongly and actively with bone marrow stem cells (BMSCs) than PPFU‐d‐PAV, leading to a larger cell spreading area, faster migration velocity, and stronger osteodifferentiation tendency.
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Posttranslational Regulation of Organic Anion Transporters by Ubiquitination: Known and Novel
Authors: Xu Da , Wang Haoxun , You Guofeng 
Published: June 2016

AbstractOrganic anion transporters (OATs) encoded by solute carrier 22 family are localized in the epithelia of multiple organs, where they mediate the absorption, distribution, and excretion of a diverse array of negatively charged environmental toxins and clinically important drugs. Alterations in the expression and function of OATs play important roles in intra‐ and interindividual variability of the therapeutic efficacy and the toxicity of many drugs. As a result, the activity of OATs must be under tight regulation so as to carry out their normal functions. The regulation of OAT transport activity in response to various stimuli can occur at several levels such as transcription, translation, and posttranslational modification. Posttranslational regulation is of particular interest, because it usually happens within a very short period of time (minutes to hours) when the body has to deal with rapidly changing amounts of substances as a consequence of variable intake of drugs, fluids, or meals as well as metabolic activity. This review article highlights the recent advances from our laboratory in uncovering several posttranslational mechanisms underlying OAT regulation. These advances offer the promise of identifying targets for novel strategies that will maximize therapeutic efficacy in drug development.
One‐dimensional dynamics of saturated incompressible porous media: analytical solutions and influence of inertia terms
Authors: Zhang Yunpeng , Pedroso Dorival M. , Ehlers Wolfgang 
Published: June 2016

SummaryThe complexity of formulations for the hydromechanical coupled mechanics of porous media is typically minimised by simplifying assumptions such as neglecting the effect of inertia terms. For example, three formulations commonly employed to model practical problems are classified as fully dynamic, simplified dynamic and quasi‐static. Thus, depending on the porous media conditions, each formulation will have advantages and limitations. This paper presents a comprehensive analysis of these limitations when solving one‐dimensional fully saturated porous media problems in addition to a new solution that considers a more general loading situation. A phase diagram is developed to assist on the selection of which formulation is more appropriate and convenient regarding particular cases of porosity and hydraulic conductivity values. Non‐dimensional formulations are proposed to achieve this goal. Results using the analytical solutions are compared against numerical values obtained with the finite element method, and the effect of porosity is investigated. Copyright © 2016 John Wiley & Sons, Ltd.
Paediatric weight management programme for children with diabetes: a pilot study
Authors: McEwan Raphaella , Gilligan Niamh 
Published: June 2016

AbstractThe purpose of this pilot was to develop a curriculum and teaching plan for weight management for children with diabetes.Session aims and objectives were discussed with the diabetes multidisciplinary team. The programme was entitled ‘Stepping Stones’ and divided into a junior (4–10 year olds) and senior (11–15 year olds) programme.The Heart of England NHS Trust cares for 408 paediatric patients with diabetes. For pilot purposes Stepping Stones took place at one hospital site (n = 148). For the juniors programme 35 patients were invited (n = 7 were due to attend sessions, n = 5 actually attended). For the seniors programme 56 patients were invited (n = 6 were due to attend sessions, n = 0 attended). For the pilot, it was decided that the programme would run once‐weekly for four weeks. Each session was 1 hour and held at the Education Centre at the hospital.Overall, the attendance at the group sessions was disappointing and meant that the results achieved from the juniors programme were not necessarily representative of the patient group. Only 40% (n = 2) of the attendees were actually overweight but one of the participants successfully lost some weight and managed to move a centile line in weight while the other continued to track the same centile line for weight. On evaluation of the programme, all children felt that the Stepping Stones programme was helpful and 60% felt that it has improved their diabetes knowledge. All participants who attended the initial session did come to each of the following sessions as well, which demonstrated good attrition rates. Copyright © 2016 John Wiley & Sons.
Acute pyelonephritis with renal vein and inferior vena cava thrombosis and pulmonary emboli in poorly controlled type 2 diabetes and HHS
Authors: Sinson Natasha , van Veen Joost J , Brown Peter , Creagh Fionuala 
Published: June 2016

AbstractRenal vein thrombosis is a rare complication of acute pyelonephritis. We report a case of a 56‐year‐old woman with poorly controlled type 2 diabetes mellitus who presented with acute pyelonephritis and hyperglycaemic hyperosmolar state (HHS), complicated by thrombosis of the renal vein extending into the inferior vena cava. She was managed with intravenous antibiotics, intravenous fluids and insulin and with therapeutic low molecular weight heparin, despite which she developed pulmonary emboli two days after the diagnosis of renal vein and inferior vena caval thrombosis. Following optimisation of the dalteparin dose with factor Xa monitoring and a prolonged course of antibiotics, she made a full recovery. Two months post‐treatment there was resolution of the renal vein thrombosis and pulmonary emboli with improvement of inflammation of the right kidney on repeat computer tomography scanning.This case highlights the need to recognise renal vein thrombosis and pulmonary emboli as complications of acute pyelonephritis, especially in combination with poorly controlled diabetes mellitus, which further increases the hypercoaguable state. Copyright © 2016 John Wiley & Sons.
Adsorption and heat‐energy‐aid desorption of cationic dye on a new thermo‐sensitive adsorbent: Methyl cellulose/calcium alginate beads
Authors: Li Zhongmin , Yao Yi , Wei Guangtao , Jiang Wenyan , Wang Yizhi , Zhang Linye 
Published: June 2016

The adsorption and heat‐energy‐aid desorption of methylene blue (MB) on a thermo‐sensitive adsorbent of methyl cellulose/calcium alginate beads (MC/CABs) has been studied. The addition of methyl cellulose intensified the desorption ability of adsorbent, and boosted the difference of adsorption capacity of adsorbent between low temperature and high temperature. At the mass ratio of methyl cellulose to sodium alginate of 2:1, the difference of adsorption capacity of MC/CABs between 20 and 60°C reached 20.48 mg g−1. The effects of temperature, time and initial MB concentration on adsorption performance were investigated in detail. The MB adsorption on MC/CABs followed the pseudo‐second‐order kinetic model. The equilibrium data was fitted well with Langmuir isotherm. The maximum adsorption capacity of 336.70 mg g−1 exhibited MC/CABs had a good adsorption capability. Thermodynamic analyses showed high temperature was not favorable to MB adsorption, and MC/CABs had a distinct superiority in desorption of adsorbate with heat‐energy‐aid. Lastly, the possible mechanisms involving in adsorption and heat‐energy‐aid desorption were presented. POLYM. ENG. SCI., 56:1382–1389, 2016. © 2016 Society of Plastics Engineers
Characterization of the catalytic disulfide bond in E. coli 4‐thiouridine synthetase to elucidate its functional quaternary structure
Authors: Veerareddygari Govardhan Reddy , Klusman Thomas C. , Mueller Eugene G. 
Published: June 2016

Abstract4‐Thiouridine at position 8 in prokaryotic tRNA serves as a photosensor for near‐UV light, and the posttranscriptional conversion of uridine to 4‐thiouridine is catalyzed by the 4‐thiouridine synthetases (s4US, also named ThiI), which fall into two classes that differ in the presence of a C‐terminal rhodanese homology domain. A cysteine residue in this domain first bears a persulfide group and then forms a disulfide bond with a cysteine residue that is conserved in both classes of s4US. Recent crystal structures suggest that s4US dimerizes in the presence of RNA substrate with domains from each subunit contributing to the binding and reaction of one RNA molecule, which raises the question of whether the catalytic disulfide bond in the longer class of s4US is formed within or between subunits. The E. coli enzyme is the best‐characterized member of the longer class of s4US, and it was examined after quantitative installation of the disulfide bond during a single catalytic turnover. Gel electrophoresis and proteolysis/MALDI‐MS results strongly imply that the disulfide bond forms within a single subunit, which provides a vital constraint for the structural modeling of the class of s4US with an appended rhodanese homology domain and the design and interpretation of experiments to probe the dynamics of the domains during catalysis.
Geometric and electronic structures of silicon fluorides (N = 4 – 6) and potential energy surfaces for dissociation reactions → SiF4 + F– and →  + F–
Authors: Koval Vitaliy V. , Minyaev Ruslan M. , Minkin Vladimir I. 
Published: June 2016

The geometric and electronic structures of a series of silicon fluorides
(n = 4 − 6) were computationally studied with the aid of density functional theory (DFT) method with B3LYP and M06‐2X functionals and coupled cluster (CCSD and CCSD(T)) methods with 6‐311++G(d,p) basis set. The nature of the Si‐F bonds in these compounds was analyzed in the framework of the natural bond orbital theory and natural resonance theory. Energy characteristics (heats of reactions and energy barriers) of the dissociation reactions
→ SiF4 + F– and
→
+ F– were calculated using the DFT and CCSD methods. The potential energy surface of elimination of a fluoride anion from
has a specific topology with valley‐ridge inflection points corresponding to bifurcations of the minimal energy reaction path. © 2016 Wiley Periodicals, Inc.
Preparation, Functionality, and Application of Metal Oxide‐coated Noble Metal Nanoparticles
Authors: Liu Shuhua , Regulacio Michelle D. , Tee Si Yin , Khin Yin Win , Teng Choon Peng , Koh Leng Duei , Guan Guijian , Han Ming‐Yong 
Published: June 2016

AbstractWith their remarkable properties and wide‐ranging applications, nanostructures of noble metals and metal oxides have been receiving significantly increased attention in recent years. The desire to combine the properties of these two functional materials for specific applications has naturally prompted research in the design and synthesis of novel nanocomposites, consisting of both noble metal and metal‐oxide components. In this review, particular attention is given to core–shell type metal oxide‐coated noble metal nanostructures (i.e., metal@oxide), which display potential utility in applications, including photothermal therapy, catalytic conversions, photocatalysis, molecular sensing, and photovoltaics. Emerging research directions and areas are envisioned at the end to solicit more attention and work in this regard.
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Task admission control policy in cloud server pools based on task arrival dynamics
Authors: Khojasteh Haleh , Mišić Jelena 
Published: June 2016

AbstractIn this paper, we propose two task admission control algorithms that utilize random task filtering: a lightweight algorithm based on long‐term estimates of average utilization and offered load, and a more complex algorithm based on instantaneous utilization. Detailed performance evaluation confirms that both algorithms are able to ensure that the system remains in the stable operating region. We have also found that more aggressive filtering tends to decrease task blocking rate and delay. Copyright © 2016 John Wiley & Sons, Ltd.
Dispersal process driving subtropical forest reassembly: evidence from functional and phylogenetic analysis
Authors: Kusumoto Buntarou , Baba Akihiro , Fujii Shin‐jiro , Fukasawa Hisakazu , Honda Megumi , Miyagi Yuta , Nanki Daisuke , Osako Takeharu , Shinohara Hikaru , Shiono Takayuki , Kubota Yasuhiro 
Published: June 2016

AbstractUnderstanding the mechanisms of secondary succession related to forest management practices is receiving increasing attention in community ecology and biodiversity conservation. Abiotic and biotic filtering are deterministic processes driving community reassembly. A functional trait or phylogeny‐based approach predicts that environmental filtering induced by clearcut‐logging results in functional/phylogenetic clustering in younger forests, while biotic filtering (competitive exclusion) promotes functional/phylogenetic overdispersion in old‐growth forests. From this perspective, we examined the patterns of functional/phylogenetic structures using tree community data (147 species × 170 plots). These data were chronosequenced from clearcut secondary forests to old‐growth subtropical forests in the Ryukyu Archipelago, with species’ trait data (leaf and stem) and species level phylogeny. To detect clustering or overdispersion in the functional and phylogenetic structures, we calculated the standardized effect size of mean nearest trait distance and mean nearest phylogenetic distance within the plots. Functional or phylogenetic clustering was relatively weak in secondary forests, and their directional change with increasing forest age was not generally detected. Mean nearest trait/phylogenetic distance for most plots fell within the range of random expectation. The results suggest that abiotic/biotic filtering related to functional traits or phylogenetic relatedness plays a diminished role in shaping species assembly during secondary succession in the subtropical forest. Our findings of functional and phylogenetic properties might shed light on the importance of dispersal (stochastic) processes in the regional species pool during community reassembly after anthropogenic disturbance. It will also contribute to the development of coordinated schemes that maintain potential species assembly processes in the subtropical forest.
Warmth and legitimacy beliefs contextualize adolescents' negative reactions to parental monitoring
Authors: LaFleur Laura K. , Zhao Yinan , Zeringue Megan M. , Laird Robert D. 
Published: June 2016

ABSTRACTThis study sought to identify conditions under which parents' monitoring behaviors are most strongly linked to adolescents' negative reactions (i.e., feelings of being controlled and invaded). 242 adolescents (49.2% male; M age = 15.4 years) residing in the United States of America reported parental monitoring and warmth, and their own feelings of being controlled and invaded and beliefs in the legitimacy of parental authority. Analyses tested whether warmth and legitimacy beliefs moderate and/or suppress the link between parents' monitoring behaviors and adolescents' negative reactions. Monitoring was associated with more negative reactions, controlling for legitimacy beliefs and warmth. More monitoring was associated with more negative reactions only at weaker levels of legitimacy beliefs, and at lower levels of warmth. The link between monitoring and negative reactions is sensitive to the context within which monitoring occurs with the strongest negative reactions found in contexts characterized by low warmth and weak legitimacy beliefs.
Increased serum brain-derived neurotrophic factor levels following electroconvulsive therapy or antipsychotic treatment in patients with schizophrenia
Authors: Li J. , Ye F. , Xiao W. , Tang X. , Sha W. , Zhang X. , Wang J. 
Published: June 2016

AbstractBackgroundMany schizophrenia patients experience residual symptoms even after treatment. Electroconvulsive therapy (ECT) is often used in medication-resistant schizophrenia patients when pharmacologic interventions have failed; however, the mechanism of action is unclear. Brain-derived neurotrophic factor (BDNF) levels are reduced in drug-naive, first-episode schizophrenia and are increased by antipsychotic treatment. We tested the hypothesis that ECT increases serum BDNF levels by measuring BDNF concentrations in schizophrenia patients before and after they received ECT.MethodsA total of 160 patients with schizophrenia were examined. The ECT group (n = 80) was treated with antipsychotics and ECT (eight to 10 sessions administered every other day). The drug therapy group (n = 80) received only antipsychotic treatment. A control group (n = 77) was recruited that served as the baseline for comparison.ResultsBaseline serum BDNF level in ECT group was lower than in controls (9.7 ± 2.1 vs. 12.4 ± 3.2 ng/ml; P < 0.001), but increased after ECT, such that there was no difference between the two groups (11.9 ± 3.3 vs. 12.4 ± 3.2 ng/ml; P = 0.362). There was no correlation between patients’ Positive and Negative Syndrome Scale (PANSS) score and serum BDNF level before ECT; however, a negative correlation was observed after ECT (total: r = −0.692; P < 0.01). From baseline to remission after ECT, serum BDNF level increased (P < 0.001) and their PANSS score decreased (P < 0.001). Changes in BDNF level (2.21 ± 4.10 ng/ml) and PANSS score (28.69 ± 14.96) were positively correlated in the ECT group (r = 0.630; P < 0.01).ConclusionsBDNF level was lower in schizophrenia patients relative to healthy controls before ECT and medication. BDNF level increased after ECT and medication, and its longitudinal change was associated with changes in patients’ psychotic symptoms. These results indicate that BDNF mediates the antipsychotic effects of ECT.