bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Arterial Anatomy of the Deltoid Ligament: A Cadaveric Study
Authors: Haynes Jacob A. , Gosselin Michelle , Cusworth Brian , McCormick Jeremy , Johnson Jeffrey , Klein Sandra 
Published: April 2017

Background: There is an increasing interest in the operative treatment of deltoid ligament disruption in the setting of chronic ankle instability. Understanding the vascular anatomy of the deltoid complex is beneficial when considering operative procedures on the medial ankle and may provide insight into factors that lead to chronic deltoid insufficiency and ankle instability. Methods: Thirty-two pairs of cadaveric specimens (64 total legs) were amputated below the knee, and the tibialis anterior, tibialis posterior, and peroneal arteries were injected with India ink and Ward’s blue latex. Specimens then underwent chemical debridement to identify the vascular supply to the deltoid ligament. A subset of specimens also underwent intraosseous debridement using the modified Spalteholz technique. Results: The vascular supply to the deltoid ligament was clearly visualized in 60 (93.8%) specimens. Fifty-eight specimens (96.7%) had arterial supply with an origin from the medial tarsal artery, 57 specimens (95%) had supply from the tibialis posterior artery, and 23 (38.3%) specimens had supply from the tibialis anterior artery. All specimens had at least 1 location of intraosseous vascular supply, either at the medial malleolus or medial talus. Conclusion: There were 3 separate extraosseous sources and 2 intraosseous sources of vascular supply to the deltoid ligament. Clinical Relevance: Knowledge of the vascular supply may aid in identifying factors that predispose a subset of patients with medial ankle sprains to failure of conservative treatment, as well as provide useful anatomic information when considering operative treatment for chronic ankle instability.
A Midterm Review of Lesser Toe Arthrodesis With an Intramedullary Implant
Authors: Harmer James Lee , Wilkinson Anthony , Maher Anthony John 
Published: April 2017

Lesser toe deformities are one of the most common conditions encountered by podiatric surgeons. When conservative treatments fail surgical correction is indicated. Many surgical options have been described to address the complex nature of these deformities but no perfect solution has been reported to date. However, with the continued advancement of internal fixation technology, interphalangeal joint (IPJ) arthrodesis with an intramedullary implant may be a good option. This retrospective study presents patient reported outcomes and complications at 6 months and 3 years following lesser toe proximal interphalangeal joint (PIPJ) arthrodesis with a polyketone intrameduallary implant (Toe Grip, Orthosolutions, UK). Between September 2011 and November 2012, a total of 38 patients attended for second toe PIPJ arthrodesis by means of the Toe Grip device. At 6 months postoperation, 94.7% of patients and at 3 years postoperation, 92.8% of patients felt that their original complaint was better or much better. Health-related quality of life scores continued to improve overtime as measured by the Manchester Oxford Foot Questionnaire. Complications were generally observational and asymptomatic. The most common complications were floating toes (17.8%), mallet deformities (14.2%), metatarsalgia (17.8%), and transverse plane deformity of the toe (10.7%). This study demonstrates excellent patient-eported outcomes with minimal symptomatic complications making the “Toe Grip” implant a safe and effective alternative fixation device for IPJ arthrodesis when dealing with painful digital deformities. Levels of Evidence: Therapeutic, Level IV: Case series
Resistance Training in Youth: Laying the Foundation for Injury Prevention and Physical Literacy
Authors: Zwolski Christin , Quatman-Yates Catherine , Paterno Mark V. 
Published: April 2017

Context: The rising incidence of physical activity– and sports-related injuries has prompted the present-day investigation of resistance training as a potential means of injury prevention and physical literacy development among youth. Evidence Acquisition: Relevant studies on the topics of athlete development, physical literacy, resistance training, and injury prevention in children and adolescents were reviewed (PubMed and Sports Discus, 1982-2016). Recommendations from consensus guidelines and position statements applicable to resistance training and injury prevention in youth, in addition to young athlete development, were reviewed. Additionally, hand searches, expert requests, article reference lists, and gray literature were utilized and reviewed for pertinent content. Study Design: Clinical review. Level of Evidence: Level 4. Results: Youth throughout the physical activity spectrum are at risk for physical activity– and sports-related injury. Of highest priority are early specializers, physically inactive youth, and young girls, owing to increased injury rates. Resistance training among these at-risk populations has been shown to reduce injury risk by up to 68% and improve sports performance and health measures, in addition to accelerating the development of physical literacy. Recent recommendations, position statements, and national initiatives advocate for the incorporation of resistance training with qualified instruction among these groups. Conclusion: Resistance training in addition to free play and other structured physical activity training can serve as a protective means against injury and a positive catalyst for the development of physical literacy to offset the impact of diminishing physical activity and early sport specialization in today’s youth.
Early Osteoarthritis After Untreated Anterior Meniscal Root Tears: An In Vivo Animal Study
Authors: Steineman Brett D. , LaPrade Robert F. , Santangelo Kelly S. , Warner Brent T. , Goodrich Laurie R. , Haut Donahue Tammy L. 
Published: April 2017

Background: Meniscal root tears cause menisci and their insertions to inadequately distribute loads and potentially leave underlying articular cartilage unprotected. Untreated meniscal root tears are becoming increasingly recognized to induce joint degradation; however, little information is known about anterior meniscal root tears and how they affect joint tissue. Purpose: To observe the early degenerative changes within the synovial fluid, menisci, tibial articular cartilage, and subchondral bone after arthroscopic creation of untreated anterior meniscal root tears. Study Design: Controlled laboratory study. Methods: Anterolateral meniscal root tears were created in 1 knee joint of 5 adult Flemish Giant rabbits, and anteromedial meniscal root tears were created in 4 additional rabbits. The contralateral limbs were used as nonoperated controls. The animals were euthanized at 8 weeks postoperatively; synovial fluid was aspirated, and tissue samples of menisci and tibial articular cartilage were collected and processed for multiple analyses to detect signs of early degeneration. Results: Significant changes were found within the synovial fluid, meniscal tissue, and tibial subchondral bone of the knees with anterior meniscal root tears when compared with controls. There were no significant changes identified in the tibial articular cartilage when comparing the tear groups with controls. Conclusion: This study demonstrated early degenerative changes within the synovial fluid, menisci, and tibial subchondral bone when leaving anterior meniscal root tears untreated for 8 weeks. The results suggest that meniscal tissue presents measurable, degenerative changes prior to changes within the articular cartilage after anterior meniscal root tears. Anterior destabilization of the meniscus arthroscopically may lead to measurable degenerative changes and be useful for future in vivo natural history and animal repair studies. Clinical Relevance: The present study is the first to investigate various tissue changes after anterior meniscal root tears of both the medial and lateral menisci. The results from this study suggest that degenerative changes occur within the synovial fluid, meniscus, and tibial subchondral bone prior to any measurable changes to the tibial articular cartilage. Further studies should expand on this study to evaluate how these components continue to progress when left untreated for long periods.
What is the evidence for the contribution of forests to poverty alleviation? A systematic map protocol
Authors: Cheng Samantha H. , Ahlroth Sofia , Onder Stefanie , Shyamsundar Priya , Garside Ruth , Kristjanson Patti , McKinnon Madeleine C. , Miller Daniel C. 
Published: April 2017

Abstract
Background
Forests provide an essential resource that support the livelihoods of an estimated 20% of the global population. Forests are thought to serve in three primary roles to support livelihoods: subsistence, safety nets, and pathways to prosperity. While we have a working understanding of how poor people depend on forests in individual sites and countries, much of this evidence is dispersed and not easily accessible. Thus, while the importance of forest ecosystems and resources to contribute to poverty alleviation has been increasingly emphasized in international policies, conservation and development initiatives and investments—the strength of evidence to support how forests can affect poverty outcomes is still unclear. This study takes a systematic mapping approach to scope, identify and describe studies that measure the effect of forest-based activities on poverty outcomes at local and regional scales. This effort builds upon an existing systematic map on linkages between conservation and human well-being in order to make this process more efficient. We will conduct a refined and updated search strategy pertinent to forests-poverty linkages to glean additional evidence from studies outside the scope of the original map. Results of this study can be used for informing conservation and development policy and practices in global forest ecosystems and highlight evidence gaps where future primary studies and systematic reviews can add value.

Methods
We build upon the search strategy outlined in McKinnon et al. (Environ Evid 1–25, 2016) and expand our search to cover a total of 7 bibliographic databases, 15 organizational websites, 8 existing systematic reviews and maps, and evidence gap maps, and solicit key informants. All searches will be conducted in English and encompass all nations. Search results will be screened at title, abstract, and full text levels, recording both the number of excluded articles and reasons for exclusion. Full text assessment will be conducted on all included article and extracted data will be reported in a narrative review that will summarize trends in the evidence, report any knowledge gaps and gluts, and provide insight for policy, practice and future research. The data from this systematic map will be made available as well, through an open access, searchable data portal and visualization tool.
Reinventing the Pre-Tang Tradition: Compiling and Publishing Pre-Tang Poetry Anthologies in Sixteenth-Century China
Authors: Chen Jing 
Published: April 2017

Abstract
This article examines how the making of pre-Tang poetry anthologies in sixteenth-century Ming China led to a reinvention of the pre-Tang poetic tradition. From the Zhengde period 正德 (1506–21) well into the Wanli reign 萬曆 (1573–1620), the compilation and publication of new pre-Tang poetry anthologies saw a dramatic increase, making the anthologizing practices in the 1500s crucial to understanding the pre-Tang tradition. Through a study of paratextual elements (book titles, tables of contents, prefaces, postscripts, etc.) in twenty-two pre-Tang poetry anthologies compiled in the 1500s, this article identifies three types of anthologizing practices. By employing quantitative and network analysis, the author hopes to historicize these practices, investigate the motivations for the anthologies, and explore their citation networks. These anthologizing practices, I conclude, gradually transformed the classification principles of previous anthologies, expanded the scope of canonized anthologies, and established a distinct pre-Tang tradition by the end of the sixteenth century.
Gendering the Planchette: Female Writer Qian Xi's (1872–1930) Spiritual World
Authors: Wang Yanning 
Published: April 2017

Abstract
Fuji (wielding the planchette, or spirit writing) was in vogue among Ming-Qing literati, and its influence extended into modern times. Existing studies focus on this popular divination itself or on men's writings related to this practice. This article, instead, explores the poetry and prose of a female writer, Qian Xi, and her writing activities associated with this divination. Qian claims that the spirits she communicated with include several female immortals and her deceased husband. Some of the questions the author explores are: What are the characteristics of Qian's writings? What inspired Qian to participate in spirit writing? What role did this practice play in Qian's life and writing? Regarding the emotions, thoughts, and works of Qian, what types of information can spirit writing and corresponding poetic and prosaic compositions provide? Instead of simplifying and disregarding the ritual of wielding the planchette as bizarre, superstitious, or even mad, the author argues that it played a meaningful role in shaping Qian's literary images and enhancing her literary productivity. More important, Qian Xi's strategies of using spirit writing to stimulate her literary creations was significant in meeting her emotional needs, highlighting her identity as a talented woman, and demonstrating the worth of her very existence.
Stress and strain distributions in the human hand-arm system using finite element analysis
Authors: Adewusi Surajudeen , Thomas Marc 
Published: April 2017

This study presents stress and strain distributions in the human hand-arm system exposed to vibrations using finite element (FE) models. Frequency weightings at shoulder, elbow, wrist and palm based on stress and strain distributions were proposed. The stress/strain-based frequency weightings around the shoulder and elbow are comparable with that reported in the International Organization for Standardization ISO 5349-1, Mechanical vibration and shock– Measurement and evaluation of human exposure to mechanical vibration – part 1: General requirements, 2001. However, stress/strain-based frequency weightings around the palm and wrist are different above 20 Hz from the weighting reported by the International Standard Organization. This study suggests the need for different frequency weightings for the assessment of the potential injury of different components of the hand-arm vibration syndrome.
Transcatheter Aortic Valve Implantation in a Patient with Unicuspid Aortic Valve
Authors: Nascimbene Angelo , Loyalka Pranav , Gregoric Igor D. , Bellera Ricardo , Malahfji Maan , Petrovic Marija , Kar Biswajit 
Published: April 2017

Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valves has been successfully performed, but there is a lack of published experience in percutaneous treatment of patients with unicuspid valves and severe aortic stenosis. We describe a case of TAVR in such a patient.
A 31-year-old woman with Turner syndrome—who had undergone coarctation repair via subclavian flap at age 7 days and an aortic valvotomy at age 6 weeks—presented with severe symptomatic aortic stenosis. She was deemed inoperable because of her severe pulmonary hypertension and numerous comorbidities; consequently, a 20-mm Edwards Sapien 3 Transcatheter Heart Valve was offered for compassionate use. Postdeployment angiography and transesophageal echocardiography and aortography revealed no aortic insufficiency.
Transcatheter aortic valve replacement for unicuspid aortic valve stenosis is technically feasible. Before implantation, particular attention should be paid to the interplay between the large single leaflet, coronary ostia, and stented valve, to select the correct size and position of the device. Some degree of intraoperative aortic migration should be anticipated.
Is Diabetes Mellitus a Risk Factor for Poor Outcomes after Left Ventricular Assist Device Placement?
Authors: Mohamedali Burhan , Yost Gardner , Bhat Geetha 
Published: April 2017

Diabetes mellitus is associated with adverse outcomes in patients with cardiovascular diseases, including heart failure. Left ventricular assist devices (LVADs) are increasingly used as life-saving therapy for advanced heart failure. The effects of pre-LVAD diabetes on long-term outcomes after LVAD implantation are not well understood. In this study, we retrospectively evaluated the effect of existing diabetes on post-LVAD outcomes.
Data on 288 LVAD recipients from 2006 through 2013 were reviewed. Patients were stratified in accordance with their histories of diabetes. Baseline demographic, laboratory, hemodynamic, and echocardiographic information before LVAD placement were reviewed, together with the post-LVAD incidence of major adverse outcomes. Kaplan-Meier analysis and Cox regression analysis were performed.
Our cohort comprised 122 patients with diabetes and 166 patients without. The mean glycosylated hemoglobin A1c level in the diabetes group was 7.4% ± 1.6%. Diabetic patients at baseline had a more adverse medical profile than did nondiabetic patients. There were no differences in major outcomes between the 2 groups other than a higher incidence of hemolysis in the diabetes group: 12 (10%) vs 5 (3%); P=0.02. There was no difference in survival outcomes between the groups.
Diabetic patients did not have worse survival or more adverse outcomes than did nondiabetic patients in this study, perhaps because of improved diabetes control, or improvement in biochemical derangements after normalization of cardiac output with LVAD therapy. A diagnosis of diabetes was an independent predictor of hemolysis. Further studies to evaluate the link between hemolysis and diabetes are indicated.
Repair of Intrapericardial Diaphragmatic Hernia during Aortic Surgery in a 78-Year-Old Woman
Authors: Spiliotopoulos Konstantinos , de la Cruz Kim I. , Gkotsis Georgios , Preventza Ourania , Coselli Joseph S. 
Published: April 2017

Intrapericardial diaphragmatic hernias are reported very rarely. Those of congenital origin are most often diagnosed in neonates, and those caused by indirect blunt trauma occur chiefly in adults. The latter type can be asymptomatic; however, the results of a computed tomographic scan can yield a definitive diagnosis. Once discovered, these hernias should be corrected to avoid severe sequelae such as bowel strangulation and necrosis, peritonitis, mediastinitis, and cardiac tamponade.
We report the case of a 78-year-old woman who presented for elective ascending aortic aneurysm repair. Computed tomographic angiograms incidentally revealed a large intrapericardial diaphragmatic hernia, which had probably developed years earlier, after a traffic accident. The patient underwent a median sternotomy and repair of the intrapericardial diaphragmatic hernia with use of a bovine pericardial patch, followed by ascending aortic and hemiarch repair, aortic valve repair, and aorto–right coronary artery bypass grafting. We discuss the details of these procedures and alternative treatment options. To our knowledge, this is the first report of concomitant aortic surgery and repair of a trauma-induced intrapericardial diaphragmatic hernia in an adult.
Does Porcine Oocytes Maturation in Vitro is Regulated by Genes Involved in Transforming Growth Factor Beta Receptor Signaling Pathway?
Authors: Budna Joanna , Celichowski Piotr , Karimi Paresto , Kranc Wiesława , Bryja Artur , Ciesiółka Sylwia , Rybska Marta , Borys Sylwia , Jeseta Michal , Bukowska Dorota , Antosik Paweł , Brüssow Klaus P. , Bruska Małgorzata , Nowicki Michał , Zabel Maciej , Kempisty Bartosz 
Published: April 2017

Summary
The oocyte growth and development in follicular environment are substantially accompanied by surrounding somatic cumulus (CCs) and granulosa cells (GCs). During these processes, the mammalian gametes reach full maturational stage and may be further successfully fertilized by single spermatozoon. These unique mechanisms are regulated by expression of clusters of genes and their biochemical signaling pathways.
In this article we described differential expression pattern of transforming growth factor beta (TGFB) gene superfamily in porcine oocytes before and after in vitro maturation (IVM).
We performed Affymetrix® microarray assays to investigate the TGFB-related genes expression profile in porcine immature oocytes and gametes cultured for 44h in vitro.
In results we found 419 different genes, 379 genes with lower expression, and 40 genes characterized by increased RNA profile. Moreover, significant up-regulation of 6 genes belonging to TGFB signaling pathway such as: TGFBR3, SMAD4, FOS, KLF10, ID1, MAP3K1 in immature porcine oocytes (before IVM), was also observed.
It may be suggested that genes involved in TGFB-related signaling pathway are substantially regulated before IVM. Furthermore, these genes may play a significant role during early stages of nuclear and/or cytoplasmic porcine oocytes maturation. The investigated transcripts may be also recommended as the markers of oocytes maturational capability in pigs.
Problems of Cancer Treatment. Part 2. Treatment Based on Modification of Anticancer Immunological Responses in Therapy
Authors: Kawiak Jerzy , Hoser Grazyna , Domagała-Kulawik Joanna 
Published: April 2017

Summary
Here we present the concept of making own patient’s anti-cancer treatment more efficient and starting at testing the efficacy of immunological system. The respective tests are suggested, with special attention devoted to tumour-induced microenvironmental changes. The tumour should be considered to represent a complex tissue in which the cancer cells communicate directly and indirectly with the surrounding cellular immunological surrounding and develope traits that promote their own survival. The results of tests allow to propose a rational, individually profiled treatment of a patient, especially directed to elimination of blocks inhibiting the immunological system due to effects of cancer cells. The elimination can be implemented using commercially available antibodies, targeted at the cell surface receptors for inhibitors of T lymphocytes (CTLA-4 and PD-1). Outcome of the therapy is slow to appear and the results used to be selective. Some patients gain long term improvement and respective predictive markers are now tested. It is assumed that the future anti-cancer therapy will be individually targeted, based on individual tests and an assistance of own immunological system of the cancer patient.