bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty acids from nutrition sources for preterm infants and their effect on plasma fatty acid profiles
Authors: Fusch Gerhard , Fink Naomi H. , Rochow Niels , Fusch Christoph 
Published: October 2024

Abstract
Background
In preterm infants, IV administration of fat is less well tolerated compared to intake via the enteral route, often resulting in hypertriglyceridemia. It is therefore recommended that parenteral fat intake should not exceed 3.5 to 4.0 g/kg/d whereas human milk can provide up to 8 g/kg/d. It is unknown whether such hypertriglyceridemic conditions are caused by a uniform increase of all fatty acids or it is linked to an elevation of distinct fatty acids due to an unbalanced intake. Obviously, both scenarios could potentially influence the formulation of novel lipid solutions for preterm infants. Objective of this exploratory study was to compare fatty acid profiles between a) different nutritional sources and corresponding plasma samples, b) plasma of infants fed breast milk versus those receiving lipid emulsion, and c) plasma of infants with normal versus elevated triglyceride levels.

Methods
Forty-seven preterm infants < 36 weeks of gestation were included; fatty acid profiles were measured in serum samples and corresponding nutritional sources (breast milk and lipid emulsion) using gas chromatography/mass spectrometry.

Results
Compared to breast milk levels, plasma contained significantly lower C8:0, C10:0, C12:0, C14:0, C19:1n9, C18:3n3 (p < 0.0001). In contrast, relative abundance of C16:0, C18:0 and C20:4n6 was higher in plasma than in corresponding breast milk samples (p < 0.001) and lipid emulsion (p < 0.01). Compared to the corresponding lipid emulsion, the abundance of C18:2n6 and C18:3n3 was significantly lower in plasma (p < 0.001). Fatty acid profiles in plasma of infants fed breast milk compared to lipid emulsion were not markedly different. Hypertriglyceridemic samples showed elevated levels for C18:1n9 and C16:0 when compared with normotriglyceridemic samples.

Conclusions
Our study reveals that lipid levels in plasma show both depletion and enrichment of distinct fatty acids which do not seem to be closely related to dietary intake. A more detailed understanding of fatty acid flux rates is needed, like the understanding of amino acid metabolism and is supported by the finding that hypertriglyceridemia might be a state of selective fatty acid accumulation. This would allow to develop more balanced diets for intensive care and potentially improve clinical outcomes.
Changing the conversation: impact of guidelines designed to optimize interprofessional facilitation of simulation-based team training
Authors: Ju Mindy , Bochatay Naike , Werne Alexander , Essakow Jenna , Tsang Lisa , Nottingham Mary , Franzon Deborah , Lyndon Audrey , van Schaik Sandrijn 
Published: October 2024

Abstract
Background
Interprofessional simulation-based team training (ISBTT) is commonly used to optimize interprofessional teamwork in healthcare. The literature documents the benefits of ISBTT, yet effective interprofessional collaboration continues to be challenged by complex hierarchies and power dynamics. Explicitly addressing these issues during ISBTT may help participants acquire skills to navigate such challenges, but guidelines on how to do this are limited.

Methods
We applied an educational design research approach to develop and pilot structured facilitator guidelines that explicitly address power and hierarchy with interprofessional teams. We conducted this work in a previously established ISBTT program at our institution, between September 2020 and December 2021. We first reviewed the literature to identify relevant educational theories and developed design principles. We subsequently designed, revised, and tested guidelines. We used qualitative thematic and content analysis of facilitator interviews and video-recording of IBSTT sessions to evaluate the effects of the guidelines on the pre- and debriefs.

Results
Qualitative content analysis showed that structured guidelines shifted debriefing participation and content. Debriefings changed from physician-led discussions with a strong focus on medical content to conversations with more equal participation by nurses and physicians and more emphasis on teamwork and communication. The thematic analysis further showed how the conversation during debriefing changed and how interprofessional learning improved after the implementation of the guidelines. While power and hierarchy were more frequently discussed, for many facilitators these topics remained challenging to address.

Conclusion
We successfully created and implemented guidelines for ISBTT facilitators to explicitly address hierarchy and power. Future work will explore how this approach to ISBTT impacts interprofessional collaboration in clinical practice.
FEATURES OF THE CONCEPTS OF TIME OF SUBJECTS WITH DIFFERENT LEADING PERSONALITY ARCHETYPE
Authors: Skleynis Viktor A. 
Published: October 2024

Purpose. The article is devoted to the study of semantic universals of time estimation by subjects with different leading personality archetype. The subject of the study is the peculiarities of assessing the time continuum associated with the leading personality archetype. The author considers the archetype as a deep semantic structure, manifested at the level of surface structures in the specifics of evaluating stimuli, including the time continuum.
Methodology. The sampling consisted of 112 people who differ in the leading personality archetype. To determine the leading personality archetype, a set of MAC "12 archetypes plus" was used, and a specialized semantic differential "time" was used to determine the subjects' ideas about the time of their lives. The processing of the received data was carried out using the method of semantic universalities.
Results. As a result of the study, data were obtained on the presence of differences in the semantic universalities of estimating the time of their lives by subjects with different leading personality archetype. At the same time, the differences obtained are relevant to the localization of the leading archetype on the axes of the archetypal space, which indicates the manifestation of the archetype at the level of semantic structures in the evaluation of the time continuum.
Practical implications. The results of the study can be used for further research of archetypes as deep semantic structures, as well as in the field of practical use of knowledge about the psychology of the archetype, such as psychological counseling or the psychology of advertising.
Characteristics and prognosis of small bowel tumors: A retrospective study
Authors: Liu Fang-Chen , Wang Ching-Hsiang , Chen Peng-Jen , Shih Yu-Lueng , Lin Hsuan-Hwai , Lin Jung-Chun , Chang Wei-Kuo , Hsieh Tsai-Yuan , Lin Gen-Min , Huang Tien-Yu 
Published: October 2024

BACKGROUND
Small bowel tumors (SBTs) are a heterogeneous group of difficult-to-diagnose tumors that account for 2%-5% of all gastrointestinal tumors. Single-balloon enteroscopy greatly enhances the diagnosis and treatment of SBTs. However, few epidemiological studies have been conducted in Taiwan to determine the clinical profile of SBTs.
AIM
To investigate the clinical characteristics, managements and prognosis of SBTs in a medical center in Taiwan.
METHODS
The study enrolled 51 patients aged 58.9 ± 8.8 years (range, 22-93) diagnosed with SBTs from November 2009 to July 2021. We retrospectively recorded clinical characteristics, indications, endoscopic findings, pathological results, management, and outcomes for further analysis.
RESULTS
A male preponderance was observed (56.8%). The most common indications were suspected small intestinal tumors (52.9%) and obscure gastrointestinal bleeding (39.2%). The most common tumor location was the ileum (41.2%). The performance of imaging studies (P = 0.004) and the types of findings (P = 0.005) differed significantly between malignant and benign SBTs. The most frequent imaging finding was a small intestinal mass (43.1%). The top three malignant tumor types were gastrointestinal stromal tumors (GISTs), adenocarcinomas, and lymphomas. Moreover, the proportions of benign and malignant tumors were 27.5% and 72.5%, respectively. The survival rates of patients with malignant tumors in the GIST and non-GIST groups differed significantly (P = 0.015). Kaplan–Meier survival analysis showed a significant difference in survival between patients in the malignant and benign groups (P = 0.04). All patients with lymphoma underwent chemotherapy (n = 7/8, 87.5%), whereas most patients with GISTs underwent surgery (n = 13/14, 92.8%).
CONCLUSION
Patients with GISTs have a significantly higher survival rate than those with other malignant SBTs. Therefore, a large-scale nationwide study is warranted to evaluate the population-based epidemiology of SBTs.
Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in a bleomycin‐induced and spirometry‐confirmed model of IPF in male mice
Authors: Petersen Asbjørn Graver , Korntner Stefanie H. , Bousamaki Jamal , Oró Denise , Arraut Alba Manresa , Pors Susanne E. , Salinas Casper Gravesen , Andersen Maja Worm , Madsen Martin Rønn , Nie Yaohui , Butts Jordan , Roqueta‐Rivera Manuel , Simonsen Ulf , Hansen Henrik H. , Feigh Michael 
Published: October 2024

AbstractThis study comprehensively validated the bleomycin (BLEO) induced mouse model of IPF for utility in preclinical drug discovery. To this end, the model was rigorously evaluated for reproducible phenotype and TGFβ‐directed treatment outcomes. Lung disease was profiled longitudinally in male C57BL6/JRJ mice receiving a single intratracheal instillation of BLEO (n = 10–12 per group). A TGFβR1/ALK5 inhibitor (ALK5i) was profiled in six independent studies in BLEO‐IPF mice, randomized/stratified to treatment according to baseline body weight and non‐invasive whole‐body plethysmography. ALK5i (60 mg/kg/day) or vehicle (n = 10–16 per study) was administered orally for 21 days, starting 7 days after intratracheal BLEO installation. BLEO‐IPF mice recapitulated functional, histological and biochemical hallmarks of IPF, including declining expiratory/inspiratory capacity and inflammatory and fibrotic lung injury accompanied by markedly elevated TGFβ levels in bronchoalveolar lavage fluid and lung tissue. Pulmonary transcriptome signatures of inflammation and fibrosis in BLEO‐IPF mice were comparable to reported data in IPF patients. ALK5i promoted reproducible and robust therapeutic outcomes on lung functional, biochemical and histological endpoints in BLEO‐IPF mice. The robust lung fibrotic disease phenotype, along with the consistent and reproducible lung protective effects of ALK5i treatment, makes the spirometry‐confirmed BLEO‐IPF mouse model highly applicable for profiling novel drug candidates for IPF.
Analyzing the existing programs on promoting women scientists in chemistry
Authors: Fung Fun Man , Markic Silvija , Mamlok-Naaman Rachel , Cesa Mark , Chiu Mei-Hung 
Published: October 2024

Abstract
Gender imbalance in science has been well documented. Possible explanations include a lack of systematic strategies or policies to support women in science in general and chemistry in particular. This article aims to analyze selected programs that advocate gender equity and inclusion in chemistry. Forty-eight initiatives were selected via several steps of screening. Following a pilot study using systematic review as a research method, the named initiatives were analyzed considering their strategies, goals, and impact. The findings reveal that acknowledging women scientists and providing funding to enable and sustain networking (such as through conferences) are crucial for women scientists to become visible and recognized in academia. In this paper, we offer recommendations for other entities who would like to develop initiatives to encourage suitable environments for gender equity.
Tracing Sanna kvinnor across the Nordic Theatre Landscape: Intermediaries and Forces of Circulation
Authors: Lindh Estelle Birgitta 
Published: October 2024

Abstract
Established historiographical accounts suggest that, following Ibsen’s A Doll’s House, plays by women playwrights made Swedish theatre into a feminist tribune for a brief period in the early 1880s but that their relevance had diminished by the latter half of the decade. By examining the circulation of Anne Charlotte Leffler’s Sanna kvinnor [True Women], 1883, in Nordic theatre between 1883 and 1925, this article critically evaluates these prevalent accounts by inclusively and comprehensively exploring previously overlooked empirical sources in now-digitized newspaper databases. This return to the archives aims at mapping the circulation of Sanna kvinnor, investigating the crucial forces driving its dissemination across the Nordic theatrical landscape, by considering the most important intermediaries: Danish playwright and priest Jens Christian Hostrup and his wife Elisabeth, and Swedish actor Emil Hillberg.
Efficacy for aspiration prevention through thickening of liquid foods evaluated using a swallowing model apparatus
Authors: Yoshida Masanori , Takako Yuichiro , Ono Haruka , Suzuki Ryota 
Published: October 2024

Abstract
An apparatus simulating the swallowing process of liquid foods was constructed using a flow channel. In the channel, a circular cylindrical obstruction was fixed to serve as an epiglottis in the mesopharynx. The apparatus was designed with an adjustable gate for flow control to represent the processes of healthy swallowing and dysphagia. The parameters considered were the holding time and flow resistance controlled by the gate, which were assumed to indicate the swallowing reflex and power, respectively. When a Newtonian liquid with relatively low viscosity was used, the flow experiment performed using the apparatus under conditions of shorter holding time and larger flow resistance successfully reproduced a phenomenon similar to aspiration in a patient with dysphagia. In addition to a Newtonian liquid with high viscosity, non-Newtonian liquids thickened to various concentrations using commercially available thickeners were used. In flow experiments with these test liquids, the efficacy for aspiration prevention was inferred based not only on the viscosity of the liquid but also its elasticity, depending on its viscosity.
Comprehensive bioinformatics analysis of lncRNA regulation and screening for pathogenic genes in NF2-related schwannomatosis
Authors: Chen Zhuming , Li Kai , Mofatteh Mohammad , Guo Weitao , Pan Lei , Wang Qingsong 
Published: October 2024

Abstract

Objectives

NF2-related Schwannomatosis (NF2-SWN) is an autosomal dominant disease with full penetrance. Increasing data shows that long non-coding RNAs (lncRNA) can act as competitive endogenous RNAs (ceRNA), regulating target gene expression. This study aims to investigate lncRNAs in NF2-SWN that may be involved in regulating NF2 pathogenic genes.

Methods
Data were collected from three patients with NF2-SWN, including medical records, physical examination, imaging, pathology, and RNA from the tumor and adjacent tissues. differentially expressed genes (DEGs) between the two groups were screened by conducting gene differential analysis on the sequenced data. Next, GO & KEGG enrichment analysis was performed on DEGs, and an association network between lncRNA and NF2 was established to identify regulatory lncRNA. Finally, qRT-PCR was used to substantiate the expression patterns of critical lncRNAs and NF2 in NF2-SWN.

Results
Sequencing revealed 6433 DEGs involved in key biological processes and pathways, such as axon guidance, intracellular signal transduction, cell migration, phosphorylation, cell adhesion molecules, taste transduction, axon guidance, and ErbB signaling pathways, etc. The ceRNA correlation network identified four lncRNAs (CADM3-AS1, MTMR9LP, LOC101929536, PRDM16-DT) that may regulate the NF2 gene. As expected, qRT-PCR results revealed that compared with the control group, the expression levels of L0C10929536 and PRDM16-DT in the tumor group were significantly increased. In contrast, the expression levels of MTMR9LP and CADM3-AS1 genes were decreased.

Conclusions
Four identified lncRNAs could be crucial for NF2-SWN development, potentially serving as diagnosis biomarkers or therapeutic targets. This study contributes to the understanding of NF2-SWN’s molecular mechanism.
Microstructure-mechanical property relationships of polymer nanocomposite reinforced with lyophilized montmorillonite/carbon nanotubes hybrid particles
Authors: Benelfellah Abdelkibir , Sanusi Olawale Monsur , Gratton Michel , Aït Hocine Nourredine 
Published: October 2024

Abstract
Introducing multi-walled carbon nanotubes (MWCNT) and montmorillonite (MMT) simultaneously into a polymer can significantly enhance its properties. Meanwhile, choosing the best technique to homogeneously disperse these nanohybrid particles in polymers, without agglomerates, is still a challenge. In this study, a hybrid MMT/MWCNT, prepared by lyophilization process, is introduced in polylactide (PLA). Morphology of the resulting nanocomposites displays synergistic relationships of the MMT/MWCNT, facilitating dispersion in PLA. The analysis of transmission electron microscopy (TEM) specific particle densities of PLA0.5hyb, PLA1.0hyb, and PLA2.0hyb shows values of 77, 64, and 35 µm⁻2, respectively. This suggests that MMT platelets are significantly more exfoliated in PLA0.5hyb compared to the other nanocomposites. It also indicates that filler aggregation increases as the MMT/MWCNT concentration increases. Compared to neat PLA, elastic modulus of nanocomposites increased by up to 46 %, demonstrating the reinforcing effect of MMT/MWCNT hybrid nanofillers. The nanocomposites exhibit viscosity, plasticity and damage phenomena, which are significantly decreased because of the MMT/MWCNT incorporation, compared to neat PLA. Furthermore, the viscoelastic properties, analyzed by dynamic thermal-mechanical analysis, record about 27 % increase in the storage modulus of the nanocomposites compared to PLA, indicating the effectiveness of the hybrid MMT/MWCNT in increasing the resistance of PLA/MMT/MWCNT nanocomposite against thermomechanical aggression.
Issues in systematizing the elicitation and analysis of syllable structure
Authors: Macaulay Benjamin 
Published: October 2024

Abstract
This reply explores issues with documenting prosodic structures given their unique relationship with metalinguistic knowledge. New evidence and perspectives are incorporated into a deeper investigation of Budai Rukai and the analytical decisions that underlie its reanalyzed prosodic system. This case study is then taken as a basis for discussion of a possible standardized protocol for the documentation of prosodic structures, in which diverse types of phonological evidence are integrated and contextualized.
Molecular hydrogen as a biological marker and a drug
Authors: Chuchalin A. G. 
Published: October 2024

The aim of the review was to examine the main characteristics of hydrogen ion metabolism and its hemostatic function in the human body. For diagnostic purposes, molecular hydrogen (H2) is considered a biological marker. The results of the analysis of therapeutic programs for the clinical use of hydrogen are presented. The use of H2 as a drug in the treatment of more than 170 diseases is also discussed.Conclusion. The use of H2 in various fields of medicine, including oncological diseases, is actively studied based on experimental biological experiments and clinical trials.
24-hour arterial stiffness profile in asthma patients with obesity
Authors: Karoli N. A. , Zarmanbetova O. T. 
Published: October 2024

Obesity is an important comorbidity in patients with asthma, and this combination is associated with increased cardiovascular risk.The aim of the study was to evaluate 24-hour arterial stiffness in asthma patients with excess body weight and obesity.Methods. The study included 100 patients with asthma who were divided into three groups according to their body mass index (BMI). The first group included 36 patients with normal BMI, the second – 40 patients with excess body weight, the third – 24 patients with obesity. The vascular stiffness parameters were evaluated in all patients using BPlab. Аоrtic pulse wave velocity, augmentation index, and arterial stiffness index were also assessed.Results. The 24-hour arterial stiffness, daytime and nighttime arterial stiffness values were increased in the patients with asthma and obesity. More than 80% of the asthma patients with obesity have higher pulse wave velocity in the daytime.Conclusion. Patients with bronchial asthma with obesity represent the risk of developing cardiovascular diseases and their complications.
Pulmonary hyalinizing granuloma: literature review and case presentation
Authors: Bazhenov A. V. , Kochurova A. V. , Petrunina E. M. , Berdnikov R. B. , Ovchinnikova E. A. 
Published: October 2024

Pulmonary hyalinizing granuloma (PHG) is an extremely rare condition. Only 170-200 cases have been described until now all over the world. There have been no reports in the Russian medical literature. Etiology of the disease is unknown. The X-ray picture is very unspecific. Tumors of lungs and pleura and infectious diseases are included in the differential line. Patients with pulmonary hyalinizing granuloma have long stabile progression of the disease, and the treatment with glucocorticoids can lead to the long lasting remission.The aim of the review was to inform pulmonologists, general practitioners, infectious disease specialists, thoracic surgeons, and oncologists about the existence of pulmonary hyalinizing granuloma, its diagnosis, clinical course, and treatment. Also we present one clinical case of patient with pulmonary hyalinizing granuloma.Conclusion. Because of very low incidence of PHG, an internist or a pulmonologist can never encounter it in their professional life. However it is worth keeping this condition in mind and including it into the diagnostic process when focal and focused shadows are identified in the lungs during chest X-ray. Probably, the disease is caused by different immune-mediatory processes, but the exact pathogenesis is still unknown. Biopsy of the lung tissue by means of lung resection is crucial for the morphological verification of the diagnosis. The prognosis of the disease is favorable. The timely initiation of treatment can sufficiently prolong the remission.
The impact of integration between lean accounting and just-in-time technique on cost reduction in modern sustainable manufacturing environment in Saudi companies
Authors: Ismael Ahmed Yousif 
Published: October 2024

This article examines the impact of integration between Lean Accounting (LA) tools and Just-in-Time (JIT) techniques on Cost Reduction (CR) in a modern sustainable manufacturing environment in Saudi companies, Ethical Standards (ESs) mediate these two variables. A quantitative methodology was used for realizing the study goals and answering study questions. The main tool used for producing the primary data was a fully structured questionnaire with closed-ended questions which was designed and distributed online through a chosen sample of 109 managers and accountants in Saudi industrialization companies. Descriptive and deductive statistics were adopted to deduce the findings. The gathered responses analyzed by SPSS and AMOS and the results pointed out that there is a direct and indirect impact of LA tools and JIT techniques on CR in Saudi industrial companies especially when using ESs. Moreover, these findings could provide decision- makers in Saudi manufacturing companies with the importance of adopting both methods in an integrated way to maximize the profits of these firms. The practical implications of this study are that the implementation of these methods has a positive impact on the promotion of sustainable manufacturing and consequently the achievement of distinct sustainable performance.