bluuebunny/crossref_metadata_2025_split huggingface dataset:
The book: production and participation
Authors: Luck Sarah Elizabeth , Lamp John William , Craig Annemieke , Coldwell-Neilson Jo 
Published: January 2016

Purpose– The focus of this paper is on the benefits that may eventuate through new mechanisms of production and distribution. As we enter the twenty-first century, the nature of the book and the structure of the industry which produces it are undergoing radical transformation, as developments in information technology offer new mechanisms for production and distribution. Most of the discussion of these changes is conducted from the perspective of what has been lost through these changes.Design/methodology/approach– This paper reviews the history of the book from the perspective of the disruptive effects of the changes in production technology and impact on the roles involved in production, distribution and reading of books. Darnton’sCommunication Circuitis updated to predict future limiting factors and opportunities for participation.Findings– The evolution of the book has seen successive categories of workers involved in book production supplanted by the adoption of new technology. The updated Darnton’s model suggests that the roles involved in the production and distribution of the book will, however, be supplanted in favour of authors and readers of the book in the future.Social implications– The predicted changes will alter the roles of authors and book users.Originality/value– This paper suggests a novel approach to the discussion of the future of book publication and suggests future developments.
Application of word co-occurrence analysis method in mapping of the scientific fields (case study: the field of Informetrics)
Authors: Sedighi Mehri 
Published: January 2016

Purpose
– The purpose of this article is to investigate the use of word co-occurrence analysis method in mapping of the scientific fields with emphasis on the field of Informetrics.

Design/methodology/approach
– This is an applied study using scientometrics, co-word analysis and network analysis and its steps are summarised as follows: collecting the data related to the Informetrics field indexed in Web of Science (WOS) database, refining and standardising the keywords of the extracted articles from WOS and preparing a selected list of these keywords, drawing the word co-occurrence map in the Informetrics field and analysing of results.

Findings
– Based on the resulted maps the concepts such as information science, library, bibliometric analysis, innovation and text mining are the most widely used topics in the field of Informetrics. The co-word occurrence maps drawn at different periods show the changes and stabilities in the concepts related to the field of Informetrics. A number of topics such as “bibliometric analysis” are present in all years, whereas others such as “innovation” have disappeared. New topics emerge as a recombination of existing topics and in interaction with new (technological) developments.

Originality/value
– The results of these analytical studies can be used as a guide for determining research priorities in the scientific fields, and also for planning and management in academic institutions.
Thermal analysis of chip-on-flexible LED packages with Cu heat sinks by SnBi soldering
Authors: Liu Yang , Sun Fenglian , Yuan Cadmus A. , Zhang Guoqi 
Published: January 2016

Purpose
– The purpose of this paper is to discuss the possibility of using soldering process for the bonding of chip-on-flexible (COF) light-emitting diode (LED) packages to heat sinks. The common bonding materials are thermal conductive adhesives. For thermal performance and reliability concerns, Tin-Bismuth (SnBi) lead-free solder paste was used for the connection of the COF packages and the Cu heat sinks by a soldering process in this study. Meanwhile, the geometrical effect of the SnBi solder layer on the thermal performance was also investigated.

Design/methodology/approach
– The effects of the bonding materials and the area of the solder layers on the thermal performance of the LED modules were investigated by finite element simulation and experimental tests.

Findings
– The SnBi soldered modules show much lower thermal resistance at the bonding layers than the adhesive-bonded LED module. Vertical heat transfer from the LED chips to the heat sinks is the primary heat dissipation mode for the SnBi soldered modules. Thus, the LED module with local solder layer shows similar LED thermal performance with the full-area soldered module. Meanwhile, the local soldering process decreases the possibility to form randomly distributed defects such as the large area voids and residue flux in the solder layers.

Research limitations/implications
– The research is still in progress. Further studies mainly focus on the reliability of the samples with different bonding materials.

Practical implications
– COF package is a new structure for LED packages. This study provides a comparison between SnBi solder and adhesive material on the thermal performance of the LED. Meanwhile, the authors optimized the geometrical design for the solder layer. The study provides a feasible bonding process for COF packages onto heat sinks.

Originality/value
– This study provides a soldering process for the COF LED packages. The thermal performance of the LED light source was improved significantly by the new process.
Peroxisome proliferator‐activated receptor‐γ coactivator‐1α mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X‐linked inhibitor of apoptosis protein
Authors: Mäkelä Johanna , Mudò Giuseppa , Pham Dan Duc , Di Liberto Valentina , Eriksson Ove , Louhivuori Lauri , Bruelle Céline , Soliymani Rabah , Baumann Marc , Korhonen Laura , Lalowski Maciej , Belluardo Natale , Lindholm Dan 
Published: January 2016

AbstractPeroxisome proliferator‐activated receptor gamma coactivator‐1α (PGC‐1α) is a transcriptional coactivator involved in the regulation of mitochondrial biogenesis and cell defense. The functions of PGC‐1α in physiology of brain mitochondria are, however, not fully understood. To address this we have studied wild‐type and transgenic mice with a two‐fold overexpression of PGC‐1α in brain neurons. Data showed that the relative number and basal respiration of brain mitochondria were increased in PGC‐1α transgenic mice compared with wild‐type mitochondria. These changes occurred concomitantly with altered levels of proteins involved in oxidative phosphorylation (OXPHOS) as studied by proteomic analyses and immunoblottings. Cultured hippocampal neurons from PGC‐1α transgenic mice were more resistant to cell degeneration induced by the glutamate receptor agonist kainic acid. In vivo kainic acid induced excitotoxic cell death in the hippocampus at 48 h in wild‐type mice but significantly less so in PGC‐1α transgenic mice. However, at later time points cell degeneration was also evident in the transgenic mouse hippocampus, indicating that PGC‐1α overexpression can induce a delay in cell death. Immunoblotting showed that X‐linked inhibitor of apoptosis protein (XIAP) was increased in PGC‐1α transgenic hippocampus with no significant changes in Bcl‐2 or Bcl‐X. Collectively, these results show that PGC‐1α overexpression contributes to enhanced neuronal viability by stimulating mitochondria number and respiration and increasing levels of OXPHOS proteins and the anti‐apoptotic protein XIAP.
The single‐chain anti‐TNF‐α antibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque‐type psoriasis
Authors: Tsianakas Athanasios , Brunner Patrick M. , Ghoreschi Kamran , Berger Claudia , Loser Karin , Röcken Martin , Stingl Georg , Luger Thomas , Jung Thomas 
Published: January 2016

AbstractIt is not clear whether TNF‐α antagonists used in the treatment of psoriasis need to act systemically, or whether local inhibition of skin‐produced TNF‐α would be sufficient to silence skin inflammation. To answer this question, we conducted two multicentre, double‐blinded, randomized, placebo‐controlled clinical trials with the novel single‐chain anti‐TNF‐α‐PENTRA®‐antibody DLX105. Upon intra‐dermal injection, DLX105 induced a mean local PASI decrease of 33% over baseline after 2 weeks of treatment, while the placebo response was only 12% (P = 0.001). The clinical response was accompanied by changes in biomarkers such as reductions in K16, Ki67 and epidermal thickness as well as decreased mRNA levels of IL‐17, TNF‐α, IL‐23p19, IL‐12p40 and IFN‐γ. Next, we applied the drug topically twice daily in a 0.5% hydrogel formulation. While the local PASI did not change, topical DLX105 mediated significant reductions of mRNA levels of key proinflammatory cytokines when compared to placebo, and this effect was further enhanced after weekly tape stripping of plaques to increase drug penetration. These results suggest that longer treatment periods and/or increased local drug concentrations might result in better therapeutic efficacy of topically applied DLX105. In sum, we can show for the first time that local inhibition of TNF‐α is sufficient to mediate a biological response in psoriasis that translates into clinical efficacy.
Antimicrobial peptides and wound healing: biological and therapeutic considerations
Authors: Mangoni Maria Luisa , McDermott Alison M. , Zasloff Michael 
Published: January 2016

AbstractRepair of tissue wounds is a fundamental process to re‐establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host‐defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non‐life‐threatening skin and other epithelial injuries.
Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin‐1
Authors: Nakamura Tomoya , Nishibu Akiko , Yoshida Naoki , Yasoshima Mitsue , Anzawa Kazushi , Watanabe Yasuharu , Nagai Yoshinori , Takatsu Kiyoshi , Ogawa Kazuo , Mochizuki Takashi 
Published: January 2016

AbstractTrichophyton infection is highly prevalent and tends to be recurrent. Therefore, it is important to develop new therapeutic agents. Previously, we established a mouse model of Trichophyton‐induced contact hypersensitivity (CHS) and demonstrated that dectin‐1 was involved in inflammation induced by trichophytin, the Trichophyton antigen. Here, we used that model to investigate glycyrrhetinic acid (GA) from plants of the genus Glycyrrhiza as a potential anti‐inflammatory agent against superficial mycoses. GA suppressed swelling and the expression of inflammatory cytokines, including macrophage inflammatory protein (MIP)‐2, interleukin (IL)‐6, tumor necrosis factor (TNF)‐α and interferon (IFN)‐γ mRNA. Anti‐MIP‐2 antibody suppressed trichophytin‐induced inflammation, and antidectin‐1 antibody suppressed zymosan‐induced MIP‐2 production in keratinocyte cells. These results suggest that MIP‐2 is produced by dectin‐1 activation and is involved in inflammation associated with CHS to trichophytin. GA also suppressed zymosan‐induced MIP‐2 and interleukin (IL)‐8, production in mouse and human macrophages and keratinocytes. Furthermore, GA suppressed the phosphorylation of spleen tyrosine kinase (Syk) and inhibitor of nuclear factor‐kappa B (IκBα) and the degradation of IκBα in zymosan‐simulated RAW264.7 cells. The results of this study suggest that GA suppresses inflammation induced by trichophytin, partly by the downregulation of Syk phosphorylation.
Adapted physical exercise enhances activation and differentiation potential of satellite cells in the skeletal muscle of old mice
Authors: Cisterna Barbara , Giagnacovo Marzia , Costanzo Manuela , Fattoretti Patrizia , Zancanaro Carlo , Pellicciari Carlo , Malatesta Manuela 
Published: January 2016

AbstractDuring ageing, a progressive loss of skeletal muscle mass and a decrease in muscle strength and endurance take place, in the condition termed sarcopenia. The mechanisms of sarcopenia are complex and still unclear; however, it is known that muscle atrophy is associated with a decline in the number and/or efficiency of satellite cells, the main contributors to muscle regeneration. Physical exercise proved beneficial in sarcopenia; however, knowledge of the effect of adapted physical exercise on the myogenic properties of satellite cells in aged muscles is limited. In this study the amount and activation state of satellite cells as well as their proliferation and differentiation potential were assessed in situ by morphology, morphometry and immunocytochemistry at light and transmission electron microscopy on 28‐month‐old mice submitted to adapted aerobic physical exercise on a treadmill. Sedentary age‐matched mice served as controls, and sedentary adult mice were used as a reference for an unperturbed control at an age when the capability of muscle regeneration is still high. The effect of physical exercise in aged muscles was further analysed by comparing the myogenic potential of satellite cells isolated from old running and old sedentary mice using an in vitro system that allows observation of the differentiation process under controlled experimental conditions. The results of this ex vivo and in vitro study demonstrated that adapted physical exercise increases the number and activation of satellite cells as well as their capability to differentiate into structurally and functionally correct myotubes (even though the age‐related impairment in myotube formation is not fully reversed): this evidence further supports adapted physical exercise as a powerful, non‐pharmacological approach to counteract sarcopenia and the age‐related deterioration of satellite cell capabilities even at very advanced age.
Benzo[a]pyrene/aryl hydrocarbon receptor signaling inhibits osteoblastic differentiation and collagen synthesis of human periodontal ligament cells
Authors: Monnouchi S. , Maeda H. , Yuda A. , Serita S. , Wada N. , Tomokiyo A. , Akamine A. 
Published: January 2016

Background and ObjectiveCigarette smoking has detrimental effects on periodontal tissue, and is known to be a risk factor for periodontal disease, including the loss of alveolar bone and ligament tissue. However, the direct effects of cigarette smoking on periodontal tissue remain unclear. Recently, we demonstrated that benzo[a]pyrene (BaP), which is a prototypic member of polycyclic aryl hydrocarbons and forms part of the content of cigarettes, attenuated the expression of extracellular matrix remodeling‐related genes in human periodontal ligament (PDL) cells (HPDLCs). Thus, we aimed to examine the effects of BaP on the osteoblastic differentiation and collagen synthesis of HPDLCs.Material and MethodsHPDLCs were obtained from healthy molars of three patients, and quantitative reverse transcription–polymerase chain reaction were performed for gene expression analyses of cytochrome P450 1A1 and 1B1, alkaline phosphatase, bone sialoprotein and aryl hydrocarbon receptor (AhR), a receptor for polycyclic aryl hydrocarbons. We have also analyzed the role of the AhR, using 2‐methyl‐2H‐pyrazole‐3‐carboxylic acid (2‐methyl‐4‐o‐tolylazo‐phenyl)‐amide (CH‐223191), which is an AhR antagonist.ResultsThe treatment of HPDLCs with BaP reduced mRNA expression of osteogenic genes, alkaline phosphatase activity, mineralization and collagen synthesis. The treatment with CH‐223191 subsequently restored the observed suppressive effects of BaP on HPDLCs.ConclusionsThe present results suggest that BaP exerts inhibitory effects on the maintenance of homeostasis in HPDL tissue, such as osteoblastic differentiation and collagen synthesis of HPDLCs, and that this signaling pathway could be suppressed by preventing the transactivity of AhR. Future studies may unveil a role for the inhibition of AhR as a promising therapeutic agent for periodontal disease caused by cigarette smoking.
Evaluation of emergency pediatric tracheal intubation by pediatric anesthesiologists on inpatient units and the emergency department
Authors: Bai Wenyu , Golmirzaie Kristine , Burke Constance , Van Veen Tara , Christensen Robert , Voepel‐Lewis Terri , Malviya Shobha 
Published: January 2016

SummaryBackground and ObjectivesThere are limited data on pediatric emergency tracheal intubation on inpatient units and in the emergency department by anesthesiologists. This retrospective cohort study was designed to describe the frequency of difficult intubation and adverse events associated with emergency tracheal intubation performed by pediatric anesthesiologists in a large children's hospital.MethodsAll emergency tracheal intubation on inpatient units and the emergency department performed by pediatric anesthesiologists over a 7‐year period in children <18 years were identified by querying our perioperative clinical information system. Medical records were comprehensively reviewed to describe the emergency intubation process and outcomes.ResultsOne hundred and thirty‐two intubations from 120 children (median age 3.3 years) were eligible. The majority of emergency tracheal intubations were successful with 1–2 laryngoscopy attempts, while 14 (10.6%) were difficult. Despite grade 3 view in 3/14 cases, the airway was secured after multiple direct laryngoscopy attempts. Eleven required use of an alternative airway device to secure the airway. A preexisting airway abnormality or craniofacial abnormality was present in 57% of cases with difficult intubation including half with micrognathia or retrognathia. Major intubation‐related adverse events such as aspiration, occurred in 5 (3.8%) emergency tracheal intubations. Mild‐to‐moderate intubation‐related adverse events occurred in 23 (17.4%) emergency tracheal intubations including mainstem bronchus intubation (13.6%).ConclusionA significant rate of difficult intubation and mild‐to‐moderate intubation‐related adverse events were found in emergency tracheal intubations on inpatient units and the emergency department in children performed by a pediatric anesthesiology emergency airway team. Difficult intubation was observed frequently in children with preexisting airway and craniofacial abnormalities and often required the use of an alternative airway device to successfully secure the airway.
Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma
Authors: Nakashima Kentaro , Kodama Yuichi , Nishikawa Takuro , Nishimura Miho , Ito Nobuhiro , Fukano Reiji , Nomura Yuko , Ueba Tetsuya , Inoue Tooru , Oshima Koichi , Okamura Jun , Inagaki Jiro 
Published: January 2016

AbstractEpstein–Barr virus associated lymphoproliferative disorder (EBV‐LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV‐LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high‐dose methotrexate (HD‐MTX) for CNS EBV‐LPD and then treated with rituximab in addition to HD‐MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD‐MTX might be effective therapy for CNS EBV‐LPD.
The Collateral Consequences of Prisonization: Racial Sorting, Carceral Identity, and Community Criminalization
Authors: Lopez‐Aguado Patrick 
Published: January 2016

AbstractIn this paper, I employ analyses of the collateral consequences of mass incarceration to consider how high‐incarceration communities are impacted by socializing processes instilled in the prison. Collateral consequences researchers have found that neighborhoods with high rates of incarceration suffer cumulative disadvantage, intensified policing, and the criminalization of residents. But overlooked in this literature is how socializing processes that are institutionalized in the prison shape the criminalization of community residents as gang‐involved. For example, I argue that the fallout of sorting imprisoned Latinos into gang‐associated groups has been the emergence of prison‐based Norteña/o, Sureña/o, and Bulldog identities in criminalized Chicana/o neighborhoods, complicating the implications mass incarceration has for marginalized communities of color. The geographic concentration of both mass incarceration and its collateral consequences not only directs aggressive policing into these residential spaces but also structures a relationship between prison and neighborhood that reinforces the recognition of community members as criminal. The appearance of Norteña/o, Sureña/o, and Bulldog identities in Latina/o neighborhoods represents some of the unanticipated consequences mass incarceration has for high‐incarceration communities, both in terms of the exportation of prison culture to the street and in terms of the extension of the prison's ability to define and construct criminality.
Feasibility study of an integrated stroke self-management programme: a cluster-randomised controlled trial
Authors: Jones Fiona , Gage Heather , Drummond Avril , Bhalla Ajay , Grant Robert , Lennon Sheila , McKevitt Christopher , Riazi Afsane , Liston Matthew 
Published: January 2016

ObjectivesTo test the feasibility of conducting a controlled trial into the effectiveness of a self-management programme integrated into stroke rehabilitation.DesignA feasibility cluster-randomised design was utilised with stroke rehabilitation teams as units of randomisation.SettingCommunity-based stroke rehabilitation teams in London.Participants78 patients with a diagnosis of stroke requiring community based rehabilitation.InterventionThe intervention consisted of an individualised approach to self-management based on self-efficacy. Clinicians were trained to integrate defined self-management principles into scheduled rehabilitation sessions, supported by a patient-held workbook.Main outcomes measuresPatient measures of quality of life, mood, self-efficacy and functional capacity, and health and social care utilisation, were carried out by blinded assessors at baseline, 6 weeks and 12 weeks. Fidelity and acceptability of the delivery were evaluated by observation and interviews.Results4 community stroke rehabilitation teams were recruited, and received a total of 317 stroke referrals over 14 months. Of these, 138 met trial eligibility criteria and 78 participants were finally recruited (56.5%). Demographic and baseline outcome measures were similar between intervention and control arms, with the exception of age. All outcome measures were feasible to use and clinical data at 12 weeks were completed for 66/78 participants (85%; 95% CI 75% to 92%). There was no significant difference in any of the outcomes between the arms of the trial, but measures of functional capacity and self-efficacy showed responsiveness to the intervention. Observation and interview data confirmed acceptability and fidelity of delivery according to predetermined criteria. Costs varied by site.ConclusionsIt was feasible to integrate a stroke self-management programme into community rehabilitation, using key principles. Some data were lost to follow-up, but overall results support the need for conducting further research in this area and provide data to support the design of a definitive trial.Trial registration numberISRCTN42534180.