bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of albumin and lactate dehydrogenase in comparison with cytokeratin 19 fragments and neuron‐specific enolase as diagnostic biomarkers for non‐small cell lung cancer
Authors: Feng Xiaodong , Yuan Ning , Xu Wei , Ji Yingying , Yu Xiaoyan , Zhang Zhijun 
Published: October 2024

AbstractBackgroundThe diagnosis of non‐small cell lung cancer (NSCLC) is a clinical issue that requires attention, and more practical and effective biomarkers need to be selected to assist in diagnosis. This study aimed to examine the diagnostic value of serum albumin (ALB), lactate dehydrogenase (LDH), cytokeratin 19 fragments (CYFRA21‐1), and neuron‐specific enolase (NSE) for NSCLC.MethodsThe clinical data of 1048 NSCLC patients and 1125 healthy subjects were extracted from electronic medical records. Receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic significance of ALB, LDH, CYFRA21‐1, and NSE for NSCLC. The Cancer Genome Atlas (TCGA) data, which included mRNA profiles for ALB and LDH expression, were acquired from TCGA Program. Finally, interactive survival scatter plots and survival analyses for NSCLC patients were evaluated using the Human Protein Atlas and Kaplan–Meier Plotter.ResultsSignificant differences were noted in the levels of ALB and LDH between NSCLC patients and healthy controls. The areas under the ROC curves (AUCs) for ALB and LDH were 0.754 (95% CI: 0.734–0.774) and 0.681 (95% CI: 0.658–0.704), respectively. Moreover, the combination of ALB and LDH raised the AUC to 0.804 (95% CI: 0.785–0.823), and the incorporation of CYFRA21‐1 and NSE further increased the AUC to 0.903 (95% CI: 0.890–0.916). Notably, ALB and LDH might be related to the overall survival of NSCLC patients.ConclusionThis study revealed that ALB and LDH in NSCLC patient serum could improve the diagnostic accuracy of conventional biomarkers for NSCLC.
Subsidence and measures in the polders of the Netherlands
Authors: Schultz Bart 
Published: October 2024

AbstractThe Netherlands consists for 65% of polders. Impoldering activities started in the beginning of the 11th century with impoldering of coastal lowlands. In the 13th century, a start was made with reclaiming of lands gained on the sea and since early 16th century with draining of lakes. Up to several metres in depth, soils consist primarily of peat and or clay. Underneath is a thick sandy layer, with lenses of clay. Especially in peat polders, subsidence and oxidation have been significant, up to 5 m, and is still going on. In clay polders, most of the subsidence took place in the first decennia after reclamation. Maximum subsidence in these polders has been 1.25 m. Over centuries, various measures have been taken to cope with the subsidence problems. These measures consist first of all in water management measures related to management not only of the subsidence process, but also of special measures with respect to buildings, structures and infrastructure. The paper presents a review of the subsidence process in the different types of polders, as well as of measures that over the centuries have been taken to cope with the developments in the polders and to cope with subsidence problems.
Lateral closing wedge high‐tibial osteotomy is a long‐lasting option for patients under the age of 55 with medial compartment osteoarthritis
Authors: Mahmoud Ahmed , Garba Bashirr , McMeniman Tim , Collins Brett , McMeniman Peter , Myers Peter 
Published: October 2024

AbstractPurposeAssess the survival of the closing wedge high tibial osteotomy (CWHTO) with failure defined as progression to total knee arthroplasty (TKA) and perioperative complications.MethodsPatients undergoing CWHTO in a single centre were included in this study. The patient's demographics, operative data and patient‐reported outcome measures were collected from the medical records. The outcomes assessed were progression to TKA, complications and patient‐reported outcome measures. The Australian joint registry was used to assess which patients progressed to TKA. A binary logistics regression is used to determine if any of the collected factors increase the likelihood of conversion to arthroplasty. Survival analysis is conducted using a Kaplan–Meier survivorship analysis with failure defined as progression to TKA.ResultsThree hundred and fifty‐four (244 males and 110 females) patients were included in the study. The average age of the group was 51 years with an average follow‐up of 18 years. Patients under the age of 55 had a lower rate of progression to TKA. At 15 years, the rate of progression to TKA was 64% and 85% for those under the age of 55 and over 55, respectively. The complication rate was 6% without any peroneal nerve palsies.ConclusionCWHTO is a good surgical option particularly when indicated in patients under the age of 55. Additionally, this technique results in a low overall complication rate with an absence of the often‐feared complication of peroneal nerve palsy.Level of EvidenceLevel III, Retrospective study.
Scar revision for persistent pain and activity limitation after exploratory laparotomy in infancy: A case series
Authors: Srinivas Shruthi , Bergus Katherine C. , Mezoff Ethan A. , Minneci Peter C. 
Published: October 2024

AbstractExploratory laparotomy in neonates is typically performed via a transverse laparotomy incision. However, this incision may be complicated by poor cosmesis and scar contracture. In three patients, primary gastroenterologists identified significant scar contractures that resulted in pain and limitations with physical activity, necessitating surgical referrals. All patients required subsequent surgical revision of their scar, which involved creation of skin flaps, repair of abdominal wall hernias if present, and reapproximation of the subcutaneous tissue. We describe this phenomenon and the resultant need for surgical management to raise awareness of these late complications and suggest subcutaneous tissue reapproximation should be performed when possible during abdominal wall closure.
Exploring Tenebrio molitor as a source of low‐molecular‐weight antimicrobial peptides using a n in silico approach: correlation of molecular features and molecular docking
Authors: Gonzalez‐de la Rosa Teresa , Marquez‐Paradas Elvira , Leon Maria J , Montserrat‐de la Paz Sergio , Rivero‐Pino Fernando 
Published: October 2024

AbstractBACKGROUNDYellow mealworm (Tenebrio molitor) larvae are increasingly recognized as a potential source of bioactive peptides due to their high protein content. Antimicrobial peptides from sustainable sources are a research topic of interest. This study aims to characterize the peptidome of T. molitor flour and an Alcalase‐derived hydrolysate, and to explore the potential presence of antimicrobial peptides using in silico analyses, including prediction tools, molecular docking and parameter correlations.RESULTST. molitor protein was hydrolysed using Alcalase, resulting in a hydrolysate (TMH10A) with a 10% degree of hydrolysis. The peptidome was analysed using LC‐TIMS‐MS/MS, yielding over 6000 sequences. These sequences were filtered using the PeptideRanker tool, selecting the top 100 sequences with scores >0.8. Bioactivity predictions indicated that specific peptides, particularly WLNSKGGF and GFIPYEPFLKKMMA, showed significant antimicrobial potential, particularly against bacteria, fungi and viruses. Correlations were found between antifungal activity and physicochemical properties such as net charge, hydrophobicity and isoelectric point.CONCLUSIONSThe study identified specific T. molitor‐derived peptides with strong predicted antimicrobial activity through in silico analysis. These peptides, particularly WLNSKGGF and GFIPYEPFLKKMMA, might offer potential applications in food safety and healthcare. Further experimental validation is required to confirm their efficacy. © 2024 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Prognostic Impact of the Cholangiolar Component in Combined Hepatocellular‐Cholangiocarcinoma: Insights From a Western Single‐Center Study
Authors: Nolasco Francisco , Fonseca Gilton Marques , de Mello Evandro S. , Kruger Jaime Arthur Pirolla , Jeismann Vagner Birk , Makdissi Fabio Ferrari , Coelho Fabricio Ferreira , Alves Venancio A. F. , Herman Paulo 
Published: October 2024

ABSTRACTIntroductionPrimary liver malignancies, such as hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and combined hepatocellular‐cholangiocarcinoma (cHCC‐CCA), represent significant contributors to global cancer‐related mortality. The diagnostic challenges associated with distinguishing cHCC‐CCA from HCC and ICC stem from their rarity and overlapping histological features.ObjectivesThis study aimed to reclassify primary liver tumors resected at a Western center and to compare clinicopathological features and prognosis among patients with HCC, ICC, and cHCC‐CCA.MethodsA retrospective analysis was conducted on patients undergoing resection for HCC, ICC, or cHCC‐CCA between 2007 and 2017. Clinical and perioperative data were collected, and pathological specimens were reclassified by a specialized pathologist. Statistical analysis was employed to compare clinical features and survival outcomes among the different tumor types.ResultsOut of the initially identified 192 patients, 140 were included in the analysis. Following reclassification, 71.42% were diagnosed with HCC, 12.14% with ICC, and 16.42% with cHCC‐CCA. Patients with HCC were predominantly male and exhibited a higher incidence of isolated liver recurrence. ICC patients more frequently underwent open procedures. Additionally, patients with HCC and cHCC‐CCA showed higher rates of cirrhosis, elevated alpha‐fetoprotein levels, and extrahepatic recurrence, while those with ICC and cHCC‐CCA demonstrated elevated CA 19‐9 levels. Overall survival and disease‐free survival were longer for HCC compared to cases with a cholangiolar component (ICC and cHCC‐CCA).ConclusionsHistological evaluation should actively incorporate the search for a cholangiolar component in primary liver tumors to prevent misdiagnosis, as its presence indicates a poorer prognosis.
Tinnitus Generation and Behavioral Changes Caused by Chronic Stress: A Behavioral and Brain Study in a Rat Model
Authors: Kim Ye Lin , Yu Hyo Jeong , Kim Min Jung , Han Jae Sang , Lim Ji Hyung , Park So Young , Park Ilyong , Park Shi Nae 
Published: October 2024

ObjectivesThis study explores the connection between chronic stress and tinnitus, a phantom auditory perception, using an animal model.MethodsRats were subjected to 2 h of daily restraint stress for 10 days. Tinnitus was assessed on the last day of stress exposure using the gap response of pre‐pulse inhibition acoustic reflex, measured at 60 dB background sound level at 8, 16, and 20 kHz. Chronic stress‐exposed rats were categorized into two groups: tinnitus (RTG) and non‐tinnitus (RNTG). Various tests, including hearing assessments (distortion product otoacoustic emissions and auditory brainstem response), behavioral evaluations (elevated plus maze test and forced swimming test), and immunohistochemical studies in the auditory and limbic brain regions, were conducted to understand the relationship between chronic stress, tinnitus, and behavioral changes.ResultsFollowing chronic restraint stress, 64.3% of the rats exhibited tinnitus with no audiometric changes. EPM and FST indicated an increase of anxiety‐ and depression‐related behavior in RTG. Immunohistochemical analyses identified specific alterations in the expression of neurotransmitter receptors within brain regions implicated in tinnitus. Specifically, we observed a decrease in γ‐aminobutyric acid A receptor α1 expression and an increase in glutamate receptor (N‐methyl‐D‐aspartate receptor subunit 1 and receptor subunit 2B) expression in specific brain region. These changes suggest a reorganization of neural circuits associated with the tinnitus generation and behavioral changes of the rats after chronic stress exposure.ConclusionChronic stress alone can be a causal factor for the generation of tinnitus and behavioral changes through altered neural activities in tinnitus‐related brain networks.Level of EvidenceNA Laryngoscope, 135:873–881, 2025
Exploiting the Potential of Decellularized Extracellular Matrix (ECM) in Tissue Engineering: A Review Study
Authors: Brouki Milan Peiman , Masoumi Farimah , Biazar Esmaeil , Zare Jalise Saeedeh , Mehrabi Arezou 
Published: October 2024

AbstractWhile significant progress has been made in creating polymeric structures for tissue engineering, the therapeutic application of these scaffolds remains challenging owing to the intricate nature of replicating the conditions of native organs and tissues. The use of human‐derived biomaterials for therapeutic purposes closely imitates the properties of natural tissue, thereby assisting in tissue regeneration. Decellularized extracellular matrix (dECM) scaffolds derived from natural tissues have become popular because of their unique biomimetic properties. These dECM scaffolds can enhance the body's ability to heal itself or be used to generate new tissues for restoration, expanding beyond traditional tissue transfers and transplants. Enhanced knowledge of how ECM scaffold materials affect the microenvironment at the injury site is expected to improve clinical outcomes. In this review, recent advancements in dECM scaffolds are explored and relevant perspectives are offered, highlighting the development and application of these scaffolds in tissue engineering for various organs, such as the skin, nerve, bone, heart, liver, lung, and kidney.
Synthesis and Self‐Assembly of Poly(4‐acetoxystyrene) Cubosomes
Authors: Schumacher Marcel , Foith Marvin , Trömer Manuel , Tänzer Nadine , Rosenfeldt Sabine , Retsch Markus , Gröschel André H. 
Published: October 2024

AbstractPolymer cubosomes (PCs) are a recent class of self‐assembled nanostructures with great application potential due to their high porosity and surface area. Currently, most reported PCs consist of polystyrene block copolymers (BCPs), for which self‐assembly parameters are rather well understood. Changing the block chemistry would be desirable to introduce more functionality; however, knowledge of adapting the self‐assembly process to new chemistries remains limited. This work, reports on synthesizing poly(ethylene oxide)‐block‐poly(4‐acetoxystyrene) and its copolymers with styrene, and provide conditions for their self‐assembly into PCs with high yield and high inner order. It is shown that the polarity of the starting solvent toward the corona block allows tuning of the final morphology by controlling the corona volume and packing parameter.
Targeting esophageal carcinoma: molecular mechanisms and clinical studies
Authors: Wang Wenjing , Ye Lisha , Li Huihui , Mao Weimin , Xu Xiaoling 
Published: October 2024

AbstractEsophageal cancer (EC) is identified as a predominant health threat worldwide, with its highest incidence and mortality rates reported in China. The complex molecular mechanisms underlying EC, coupled with the differential incidence of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) across various regions, highlight the necessity for in‐depth research targeting molecular pathogenesis and innovative treatment strategies. Despite recent progress in targeted therapy and immunotherapy, challenges such as drug resistance and the lack of effective biomarkers for patient selection persist, impeding the optimization of therapeutic outcomes. Our review delves into the molecular pathology of EC, emphasizing genetic and epigenetic alterations, aberrant signaling pathways, tumor microenvironment factors, and the mechanisms of metastasis and immune evasion. We further scrutinize the current landscape of targeted therapies, including the roles of EGFR, HER2, and VEGFR, alongside the transformative impact of ICIs. The discussion extends to evaluating combination therapies, spotlighting the synergy between targeted and immune‐mediated treatments, and introduces the burgeoning domain of antibody–drug conjugates, bispecific antibodies, and multitarget‐directed ligands. This review lies in its holistic synthesis of EC's molecular underpinnings and therapeutic interventions, fused with an outlook on future directions including overcoming resistance mechanisms, biomarker discovery, and the potential of novel drug formulations.
An additively manufactured dual circularly polarized open‐ended waveguide antenna using outer ridges with wideband characteristic
Authors: Ma Zi Long , Zhang Chu Wei 
Published: October 2024

AbstractThis paper presents a novel additively manufactured wideband dual circularly polarized (CP) open‐ended waveguide (OEW) antenna, which adopts a pair of wedge‐shaped outer ridges acting as a circular polarizer. Study found that compared to the con‐ ventional designs that employ internal polarization converting structures, such outer ridges are capable of achieving wider axial ratio bandwidth (ARBW) and better reflection coefficients. On each ridge, two rectangular slots are designed to suppress the higher order mode caused by the increased waveguide size, and further expanding the ARBW. The proposed antenna is fed by two differential ports. By switching the feeding ports, the CP states can be altered to either right‐handed CP (RHCP) or left‐handed CP (LHCP). In terms of configuration, the proposed antenna has a simple one‐piece structure and is fabricated by using dielec‐ tric 3‐D printing technology. To form the waveguide walls, its partial surfaces are coated by copper films through electroplat‐ ing. The proposed antenna features easy fabrication and light weight. Experimental results show that the proposed antenna has an impedance bandwidth of larger than 47.6% (8–13 GHz) with reflection coefficients lower than −15 dB, while the 3‐dB ARBW is 37.7% from 8.4 to 12.3 GHz.
Dosimetry in MRgPT: Impact of magnetic fields on TLD dose response during proton irradiation
Authors: Fuchs Hermann , Palmans Hugo , Heilemann Gerd , Zuschlag Dominik , Georg Dietmar , Kuess Peter 
Published: October 2024

AbstractBackgroundProton beam therapy, when integrated with MRI guidance, presents complex dosimetric challenges due to interactions with magnetic fields. Prior research has emphasized the nuanced impact of magnetic fields on dosimetry. For thermoluminescent dosimeters (TLDs) the electron‐return effect, alongside small air cavities surrounding the pellets, can lead to nonuniform dose distributions. Future MR‐guided proton therapy will require reliable methods for end‐to‐end tests and dosimetric audits, which so far are often performed using TLDs equipped with phantoms. This implicates the necessity of accounting for these interactions.PurposeThis study investigates the influence of magnetic fields on TLDs at two proton energies, using magnetic field strengths of 0, 0.25, and , aiming to clarify their impact on dose measurement accuracy.MethodsThe study was conducted at a synchrotron‐based ion beam therapy beam line, enhanced by a resistive dipole magnet for creating magnetic fields up to to simulate MR‐guided proton therapy. Individual correction factors were applied for TLD measurements. The impact of air gaps on the TLD signal was evaluated using three dedicated TLD holders with air gaps of 0.1, 0.25, and 0.5 mm surrounding the TLD pellets using the highest available proton energy of . Additionally, the influence of the magnetic field strength on the TLD response was evaluated for two proton energies of and .ResultsThe study found no statistically significant variation in TLD dose response attributable to changes in the air gap or the presence of magnetic fields. A power analysis indicated an upper limit on a potential change in dose‐response as small as 1.5%.ConclusionsThe findings suggested that the impact of air gap variations and magnetic field strengths on the TLD response was below the detection threshold of TLD sensitivity. This emphasizes the suitability of TLDs for dose measurement in MR‐guided proton therapy, indicating that additional correction factors may not be necessary despite the influence of magnetic fields.
Streaming First‐Order Optimization Methods With Momentum for Dominant Eigenspace Estimation
Authors: Zhou Siyun 
Published: October 2024

ABSTRACTIn this article, we consider the dominant eigenspace recovery for PCA in the streaming scenario, and design several new algorithms for this problem by incorporating various momentum schemes into two classical gradient based streaming eigensolvers, which emerges as a frequently‐used trick in improving gradient type methods. Theoretically, we establish the convergence guarantees of the proposed first‐order momentum methods, and prove their decreasing variance under favorable conditions. Extensive numerical experiments are conducted to corroborate the result that momentum does yield variance reduction, and also highlight the advantages of lowering the stepsize sensitivity. In addition, our methods with appropriately chosen momentum yield a dramatically enhanced performance in terms of both the convergence speed and accuracy.
Incidence and Risk Factors for Toxic Shock Syndrome After Endoscopic Sinus Surgery: A Systematic Review
Authors: O'Shaughnessy Jillian , Chiu Jerlon , Shim Timothy , Liao Yunhan , Yang Jie , Chung Sunny , Koos Jessica , Marcus Sonya 
Published: October 2024

AbstractObjectiveToxic shock syndrome (TSS) is a rare but serious complication after sinonasal surgery and a commonly cited consideration for prescribing antibiotics when nasal packing or stents are placed. Most reports are limited to case reports or small series. The aim of this systematic review was to describe the incidence, risk factors, and clinical course of patients who developed TSS as a complication of endoscopic sinus surgery (ESS) and/or septoplasty.Data SourcesA systematic review was conducted using MEDLINE, EMBASE, CINAHL, Web of Science, and Cochrane Library databases.Review MethodsEligibility criteria were patients of any age who developed TSS as a complication of ESS and/or septoplasty.ResultsTwenty‐five studies were included in the final review. Seventy cases were identified over 38 years (1982‐2020). The pooled incidence of TSS after sinonasal surgery was 0.0003 (0.0002‐0.0004, 95% confidence interval, CI) or 30 per 100,000 persons. Among 33 patients with single‐subject data, mean age was 33.8 years (29.73‐37.87, 95% CI). Seventeen (51.5%) patients had nasal packing, 3 (9.1%) had stents, 5 (15.2%) had both, 7 (21.2%) had none. Fourteen (42.4%) patients had nonabsorbable packing and 5 (15.2%) had absorbable packing. Sixteen (48%) patients received peri‐operative antibiotics. Thirty‐two (97%) patients had full recovery.ConclusionThe incidence of TSS after sinonasal surgery is very rare. TSS can occur with and without nasal packing and prophylactic antibiotics were not protective. Outcomes were favorable with appropriate recognition and management. Further study is needed to determine which patients are most at risk for TSS.