bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies
Authors: Gopal Sreeja , Mikulskis Alvydas , Gold Ralf , Fox Robert J , Dawson Katherine T , Amaravadi Lakshmi 
Published: February 2017

Background: Delayed-release dimethyl fumarate (DMF) is an approved oral treatment for relapsing forms of multiple sclerosis (MS). Preclinical studies demonstrated that DMF activated the nuclear factor E2–related factor 2 (Nrf2) pathway. DMF and its primary metabolite monomethyl fumarate (MMF) were also shown to promote cytoprotection of cultured central nervous system (CNS) cells via the Nrf2 pathway. Objective: To investigate the activation of Nrf2 pathway following ex vivo stimulation of human peripheral blood mononuclear cells (PBMCs) with DMF or MMF, and in DMF-treated patients from two Phase 3 relapsing MS studies DEFINE and CONFIRM. Methods: Transcription of Nrf2 target genes NADPH:quinone oxidoreductase-1 (NQO1) and heme-oxygenase-1 (HO1) was measured using Taqman® assays. RNA samples were isolated from ex vivo–stimulated PBMCs and from whole blood samples of 200 patients each from placebo, twice daily (BID) and three times daily (TID) treatments. Results: DMF and MMF induced NQO1 and HO1 gene expression in ex vivo–stimulated PBMCs, DMF being the more potent inducer. Induction of NQO1 occurred at lower DMF concentrations compared to that of HO1. In DMF-treated patients, a statistically significant induction of NQO1 was observed relative to baseline and compared to placebo. No statistical significance was reached for HO1 induction. Conclusion: These data provide the first evidence of Nrf2 pathway activation from two large pivotal Phase 3 studies of DMF-treated MS patients.
Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats
Authors: Wei Jinrong , Li Meng , Wang Dieyu , Zhu Hongyan , Kong Xiangpeng , Wang Shusheng , Zhou You-Lang , Ju Zhong , Xu Guang-Yin , Jiang Guo-Qin 
Published: February 2017

Background Cancer-induced pain (CIP) is one of the most severe types of chronic pain with which clinical treatment remains challenging and the involved mechanisms are largely unknown. Suppressor of cytokine signaling 3 (SOCS3) is an important intracellular protein and provides a classical negative feedback loop, thus involving in a wide variety of processes including inflammation and nociception. However, the role of SOCS3 pathway in CIP is poorly understood. The present study was designed to investigate the role of SOCS3 in dorsal root ganglion (DRG) in the development of CIP. Method CIP was established by injection of Walker 256 mammary gland tumor cells into the rat tibia canal. Whole-cell patch clamping and Western blotting were performed. Results Following the development of bone cancer, SOCS3 expression was significantly downregulated in rat DRGs at L2–L5 segments. Overexpression of SOCS3, using lentiviral-mediated production of SOCS3 at spinal cord level, drastically attenuated mechanical allodynia and body weight-bearing difference, but not thermal hyperalgesia in bone cancer rats. In addition, overexpression of SOCS3 reversed the hyperexcitability of DRG neurons innervating the tibia, and reduced abnormal expression of toll-like receptors 4 in the DRGs. Conclusions These results suggest that SOCS3 might be a key molecular involved in the development of complicated cancer pain and that overexpression of SOCS3 might be an important strategy for treatment for mechanical allodynia associated with bone cancer.
The chronic myeloid leukemia stem cell: stemming the tide of persistence
Authors: Holyoake Tessa L. , Vetrie David 
Published: February 2017

Abstract
Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self-renews, proliferates, and differentiates to give rise to a myeloproliferative disease. Although tyrosine kinase inhibitors (TKIs) that target the kinase activity of BCR-ABL1 have transformed CML from a once-fatal disease to a manageable one for the vast majority of patients, only ∼10% of those who present in chronic phase (CP) can discontinue TKI treatment and maintain a therapy-free remission. Strong evidence now shows that CML LSCs are resistant to the effects of TKIs and persist in all patients on long-term therapy, where they may promote acquired TKI resistance, drive relapse or disease progression, and inevitably represent a bottleneck to cure. Since their discovery in patients almost 2 decades ago, CML LSCs have become a well-recognized exemplar of the cancer stem cell and have been characterized extensively, with the aim of developing new curative therapeutic approaches based on LSC eradication. This review summarizes our current understanding of many of the pathways and mechanisms that promote the survival of the CP CML LSCs and how they can be a source of new gene coding mutations that impact in the clinic. We also review recent preclinical approaches that show promise to eradicate the LSC, and future challenges on the path to cure.
feature article: Can catalogues be dangerous? The anti-catalogue of FilmCentrum
Authors: Ramstedt Stefan 
Published: February 2017

Abstract
This article offers a survey of the film distribution of FilmCentrum during the first years of the organization. Like the catalogues of other film cooperatives that were working with distribution, FilmCentrum’s was open, which meant that the organization accepted all submitted films. This openness is discussed at length, both in terms of the discourses around it and the controversies that it aroused, but also as a form of democratization of the film distribution. The notion of the open catalogue is also put into the context of a larger counter-cultural movement and connected to the notion of the anti-catalogue. The film distribution of FilmCentrum is also placed in the context of the history of Swedish cinema.
feature article: Embodying transnational shared space: Pirjo Honkasalo’s The 3 Rooms of Melancholia
Authors: Mrozewicz Anna Estera 
Published: February 2017

Abstract
The article investigates the ways in which Pirjo Honkasalo’s documentary The 3 Rooms of Melancholia (2004), examining the impact of the Russian-Chechen war on children, engenders a transnational audience through cinematic qualities, and most importantly through embodiment, producing a strongly affective resonance in the spectator. I argue that through a strategically affective approach to transnationality, the documentary establishes what I call a transnational shared space, structured by a complex dialectics of sharing and non-sharing. My argument revolves around the concept of cinema as a shared space, referring to films that deliberately ‘surround’ the viewer rather than maintain a distance. As the analysis shows, Honkasalo’s documentary pushes the spectator to reflect critically on transnationality and reconsider mass media-created memory of the military conflict. The article addresses issues underlying the film’s ethical quest, such as whether this shared space involves both western (Catholic) and non-western (Orthodox and Muslim) audiences, and what the limits are of transnationalism in documentary film.
feature article: Women, vulnerability and depression: The cruel optimism of not giving a damn in Good Girl
Authors: Dancus Adriana Margareta 
Published: February 2017

Abstract
The 2000s have witnessed the proliferation of Scandinavian films in which women directors turn the camera towards themselves in projects that combine methods from fiction and documentary filmmaking. An evocative example is Norwegian director Solveig Melkeraaen’s film from 2014, Flink pike (Good Girl), in which Melkeraaen sets out to investigate her own depression. The film is a collage of real time recordings, highly stylized staged scenes, archival material such as old pictures and audio-recordings of her own therapy sessions, and clips from Melkeraaen’s earlier documentaries. In this article, I investigate this collage not only as an aesthetic experiment with the documentary genre, but also as a mechanism that fleshes out important questions about the politics and ethics of vulnerability in gender-minded Scandinavia.
Penyelesaian Numerik Persamaan Advection Dengan Radial Point Interpolation Method dan Integrasi Waktu Dengan Discontinuous Galerkin Method
Authors: Sadono Kresno Wikan 
Published: February 2017

Persamaan differensial banyak digunakan untuk menggambarkan berbagai fenomena dalam bidang sains dan rekayasa. Berbagai masalah komplek dalam kehidupan sehari-hari dapat dimodelkan dengan persamaan differensial dan diselesaikan dengan metode numerik. Salah satu metode numerik, yaitu metode meshfree atau meshless berkembang akhir-akhir ini, tanpa proses pembuatan elemen pada domain. Penelitian ini menggabungkan metode meshless yaitu radial basis point interpolation method (RPIM) dengan integrasi waktu discontinuous Galerkin method (DGM), metode ini disebut RPIM-DGM. Metode RPIM-DGM diaplikasikan pada advection equation pada satu dimensi. RPIM menggunakan basis function multiquadratic function (MQ) dan integrasi waktu diturunkan untuk linear-DGM maupun quadratic-DGM. Hasil simulasi menunjukkan, metode ini mendekati hasil analitis dengan baik. Hasil simulasi numerik dengan RPIM DGM menunjukkan semakin banyak node dan semakin kecil time increment menunjukkan hasil numerik semakin akurat. Hasil lain menunjukkan, integrasi numerik dengan quadratic-DGM untuk suatu time increment dan jumlah node tertentu semakin meningkatkan akurasi dibandingkan dengan linear-DGM. [Title: Numerical solution of advection equation with radial basis interpolation method and discontinuous Galerkin method for time integration] Differential equation is widely used to describe a variety of phenomena in science and engineering. A variety of complex issues in everyday life can be modeled with differential equations and solved by numerical method. One of the numerical methods, the method meshfree or meshless developing lately, without making use of the elements in the domain. The research combines methods meshless, i.e. radial basis point interpolation method with discontinuous Galerkin method as time integration method. This method is called RPIM-DGM. The RPIM-DGM applied to one dimension advection equation. The RPIM using basis function multiquadratic function and time integration is derived for linear-DGM and quadratic-DGM. The simulation result shows that this numerical method, close to the results exact well. The results of numerical simulations with RPIM-DGM show, the more nodes and the smaller the time increment, the more accurate the numerical results. Other results showed, integration with quadratic-DGM for a time increment, and a certain number of nodes, further improving accuracy, compared with the linear-DGM.
Analisis Level Kesiapan Warga Menghadapi Potensi Bencana Longsor Kota Semarang
Authors: Susanto Novie , Putranto Thomas Triadi 
Published: February 2017

Semarang memiliki morfologi bervariasi yang berpotensi terhadap bencana tanah longsor. Daerah rawan longsor ini mengakibatkan kerugian yang tidak sedikit baik sisi ekonomi sosial seperti bangunan (vihara, talud, rumah dan sebagainya) maupun nyawa manusia. Dalam hal ini manusia banyak dirugikan meskipun aktivitas manusia juga terdeteksi sebagai salah satu penyebab utama terjadinya bencana longsor. Untuk mengurangi kerugian yang mungkin ditimbulkan oleh bencana longsor di Kota Semarang perlu diketahui status kesiapsiagaan warga sehingga prioritas sosialisasi dan intervensi dapat terarah dengan baik. Metode yang digunakan dalam penelitian ini adalah mengukur indeks kesiapsiagaan warga di 19 lokasi titik penelitian rawan bencana longsor. Hasil penelitian menunjukkan secara umum, kesiapsiagaan masyarakat Semarang masuk dalam kategori “Hampir Siap” dengan nilai indeks 55,74. Terdapat 2 lokasi yang memiliki indeks kesiapsiagaan “BelumSiap” yaitu Kembang Arum dan Manyaran. Daerah Mangunharjo berada dalam kategori indeks cukup siap. Ketiga daerah ini berada di daerah dengan tingkat kerawanan cukup tinggi sehingga diprioritaskan untuk mendapatkan sosialisasi dan intervensi yang diperlukan. [Title: Analysis of Citizens’ Preparedness Level toward Potency of Landslides Disaster in Semarang City] Semarang has different morphology and by doing so caused a high potential for landslides. This case resulted in the losses of the landslide-prone area both for the social economy such as buildings (temples, embankments, homes, etc.) and human lives. In this case, the man obtained many disadvantages although human activity is also detected as one of the main causes of the landslide. To reduce the losses, it is needed to know the status of citizens’ preparedness so that the priority of socialization and interventions can be targeted properly. The method used in this study is the measurement of the preparedness index of residents in 19 locations of landslides-prone areas. The results showed in general, the community preparedness Semarang in the category "Almost Ready" with an index value of 55.74. There are two locations that have an index of preparedness "Not Ready" namely Kembang Arum and Manyaran. Mangunharjo area is in the category of the index “Quite Ready”. Those areas are located in areas with fairly high degree of vulnerability. So they are prioritized for the socialization and the interventions.
Reliability and Factorial Validity of Non-Specific and Tennis-Specific Pre-Planned Agility Tests; Preliminary Analysis
Authors: Sekulic Damir , Uljevic Ognjen , Peric Mia , Spasic Miodrag , Kondric Miran 
Published: February 2017

Abstract
Agility is an important quality in tennis, yet there is an evident lack of studies focussing on the applicability of tennis-specific agility performances and comparing them to equivalent non-specific agility performances. The aim of this study was to evaluate the reliability and factorial validity of three tests of pre-planned agility, performed in specific (with a tennis racquet) and non-specific (without a tennis racquet) conditions. The sample consisted of 33 tennis players (13 males and 20 females; age: 18.3 ± 1.1 years and 18.6 ± 1.3 years; body height: 185.4 ± 51 cm and 169.3 ± 4.2 cm, 74.0 ± 4.4 kg and 61.2 ± 3.1 kg, respectively). The variables comprised three agility tests: a 20-yard test, a T-test and the Illinois test, all performed in both specific and non-specific conditions. Between-subject and within-subject reliability were found to be high (Cronbach Alpha: 0.93 to 0.98; Coefficient of Variation: 3 to 8%), with better within-subject reliability and stability of the measurement for specific tests. Pearson’s product moment correlations between the non-specific and specific agility performances were high (r ≥0.84), while factor analysis extracted only one significant latent dimension on the basis of the Guttman-Kaiser criterion. The results of the 20-yard test were better when the test was conducted in the specific conditions (t-test = 2.66; p < 0.05). For the Illinois test, superior results were recorded in the non-specific conditions (t-test = 2.96; p < 0.05), which can be explained by the test duration (about 20 s) and non-specific locomotion forms such as rotational movements. Considering the findings of the present study, when testing tennis-specific pre-planned agility, we suggest using tests of short duration (less than 10 s) and sport-specific types of locomotion.
Job strain and binge eating among Brazilian workers participating in the ELSA-Brasil study: does BMI matter?
Authors: Gralle Ana Paula Bruno Pena , Moreno Arlinda Barbosa , Juvanhol Leidjaira Lopes , da Fonseca Maria de Jesus Mendes , Melo Enirtes Caetano Prates , Nunes Maria Angélica Antunes , Toivanen Susanna , Griep Rosane Härter 
Published: February 2017

Abstract

Objective
To assess the association between job strain and binge eating as well as the effect-modifying influence of body mass index (BMI) on this association.

Methods
A total of 11,951 active civil servants from the multicenter Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) was included in this cross-sectional analysis. Job strain was assessed using the Demand-Control-Support Questionnaire. Binge eating was defined as eating a large amount of food with a sense of lack of control over what and how much is eaten in less than 2 hours at least twice a week. Multiple logistic regression was used to determine the association between binge eating and job strain as well as its interaction with BMI.

Results
After adjustment, and using low-strain job as the reference category, binge eating was associated with high-strain job (high demand/low control: odds ratio [OR] = 1.58, 95% confidence interval [CI] 1.26-1.98), active job (high demand/high control: OR =1.35, 95% CI 1.07-1.70), and passive job (low demand/low control: OR=1.24, 95% CI 1.01-1.53). Psychological job demands were positively associated with binge eating (OR=1.04, 95% CI 1.01-1.07), while greater job control and social support at work were each inversely associated with binge eating (OR = 0.95, 95% CI 0.92-0.97 and OR = 0.96, 95% CI 0.94-0.98, respectively). BMI modified the association between job strain and binge eating: Heavier psychological job demands were associated with higher odds of binge eating among obese participants, while a stronger inverse association between job control and binge eating was seen among slimmer participants.

Conclusions
Job strain increases the odds of binge eating and this association is modified by BMI.
From Conducting Polymers to Electroactive Hybrid Materials
Authors: Gómez-Romero Pedro , Lira-Cantú Monica 
Published: February 2017

AbstractElectron or hole conductivity in conjugated polymers provided their initial thrust, but conductive polymers also display interesting electrochemical properties which constitute the base for their application in different types of electro-ionic devices. A further step in the development of functional materials based on conductive polymers is provided by the design of hybrid materials. In hybrid organic-inorganic materials based on conductive polymers, the electroactivity of molecular doping species or other inorganic components is added to that of the polymers themselves, leading to a whole new spectrum of hybrid materials that allow for the harnessing and control of the electrochemical properties of molecular species and put them to work in the development of all sorts of functional materials and devices, from sensors or catalysts to rechargeable lithium batteries, supercapacitors or photoelectrochemical devices. In this chapter we present several examples of this type of functional materials, their synthesis, properties and applications. We will present a general overview of this field and will discuss in some detail the design of insertion electrodes based on conducting polymers and hybrid organicinorganic materials based on them, analyzing their peculiar ion-inserting mechanisms and their possible application in energy storage devices.
Particle-Doped Organic-Inorganic Hybrid Coatings as Corrosion Inhibiting Surface Treatments for Aluminum Alloys
Authors: Metroke Tammy L. , Kachurina Olga , Knobbe Edward T. 
Published: February 2017

AbstractOrganically-modified silicate (Ormosil) films have been found to provide good corrosion resistance for metal substrates and are potential replacement systems for hexavalent chromiumbased conversion coatings. Significant enhancement in corrosion resistance properties were observed upon addition of sub-micron to micron-sized particles (TiO2, Al2O3, SiN, TiN) to the Ormosil coating as determined using accelerated salt spray and electrochemical analysis. Rcorr values derived from potentiodynamic polarization curves were found to increase from 1520 to (3800 - 4680) kΩcm2 upon addition of various concentrations of TiO2, Al2O3, SiN or TiN particles to the Ormosil thin film. Similarly, Epit values were found to range from +0.2 V for the non-doped Ormosil to (0.6 – 1.9) V for particle-doped Ormosil thin films.
In-situ Polymerization vs direct Polymer Incorporation for the Nanocomposite PSS/LDH
Authors: Leroux Fabrice , Moujahid El Mostafa , Cellier Joël , Besse Jean-Pierre 
Published: February 2017

AbstractInterleaved polystyrene sulfonate polymer between a layered double hydroxide of composition Zn2Al(OH)6Cl. nH2O are prepared either by direct exchange or by in-situ polymerization of the monomer. The latter is confirmed by 13C CP-MAS solid state NMR spectroscopy. This technique provides also clear evidence of the strong interaction between the incorporated monomer and the LDH inorganic framework. A shielding of the aromatic carbon attached to the sulfonate group is observed, this is transmitted through the carbonaceous skeleton to the vinylic carbon. The 2D structure is stabilized with the presence of organic moieties, and even more through the in-situ polymerization process, as exemplified with the conversion from Oh to Td aluminium cations environment. However the difference is diminished with the heating process. The exfoliation/restacking process is found to be here unappropriate, giving rise to ill-defined materials.
Modelling the Structure and Properties of Aluminophosphonates
Authors: Grewal Paramjit , Wright Paul A , Edgar Mark , Gale Julian D , Cox Paul A 
Published: February 2017

AbstractSeveral aluminophosphonate materials have been investigated using both semi-empirical quantum mechanical and Density Functional Theory (DFT) methodologies. The optimised structures obtained are in excellent agreement with experimental results. Important information on the electronic distribution in these structures is obtained, allowing charge distributions to be determined and H2O-framework interactions to be probed. The barriers to rotation for the organic groups in three structures have been investigated. Results for –(CH3) groups in AlMePO-α and AlMePO-β, yield barrier heights that are consistent with rapid rotation at ambient temperature, whereas the barrier height obtained for –(C6H5) in AlBzPO-I suggests that the framework will significantly hinder rotation. The use of modelling to help elucidate the structure of a novel compound, AlMePO-2, and to probe the structure and stability of a hypothetical aluminium ethyl phosphonate, AlEtPO, are also illustrated.
Tin-Based Hybrid Materials as Precursors of Mesoporous Tin Oxide
Authors: Jousseaume Bernard , Riague Hocine , Toupance Thierry , Lahcini Mohamed 
Published: February 2017

AbstractAlkylene-, arylene- or benzylene-bridged ditin hexachlorides were obtained in high yields from the reaction of the corresponding hexacyclohexylated compounds with tin tetrachloride. These intermediates were successfully transformed into the corresponding alkynides, which gave gels of hybrid materials on hydrolysis. This is the first example of a gel formation from a organometal with the metal fully substituted with covalently-linked organic groups. Subsequent thermal treatment led to mesoporous tin oxide with high surface area and narrow pore size distribution.