bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective Luminescent Labeling of DNA and RNA Quadruplexes by π‐Extended Ruthenium Light‐Up Probes
Authors: Saadallah Dounia , Bellakhal Mehdi , Amor Souheila , Lefebvre Jean‐François , Chavarot‐Kerlidou Murielle , Baussanne Isabelle , Moucheron Cécile , Demeunynck Martine , Monchaud David 
Published: January 2017

AbstractA series of RuII complexes exhibiting π‐extended, acridine‐based ancillary chelating heterocycles display high affinity and selectivity for DNA and RNA quadruplexes. The most promising candidates (3, 4) possess remarkable light‐up luminophore properties (up to 330‐fold luminescence enhancement upon interaction with quadruplexes), enabling them to discriminate quadruplexes from genomic DNA owing to a photochemical mechanism involving DNA protection against non‐radiative decay (DAND), thus deviating from the other complexes of this series of ligands that exhibit an excited‐state intramolecular proton transfer (ESIPT) that quenches their luminescence. The in vitro and preliminary in cellulo results shown here confirm the interest of this new family of fluorophores as invaluable molecular tools to detect G‐quadruplexes in cells.
A Versatile and Highly Selective Colorimetric Sensor for the Detection of Amines
Authors: Diaz Yvonne J. , Page Zachariah A. , Knight Abigail S. , Treat Nicolas J. , Hemmer James R. , Hawker Craig J. , Read de Alaniz Javier 
Published: January 2017

AbstractThe utility of Meldrum's activated furan (MAF) for the colorimetric detection of sub ppm levels of amines in solution, on solid supports, and as vapors is reported. MAF is synthesized in one step from inexpensive and commercially available starting materials and exhibits high selectivity for primary and secondary amines in the presence of competing nucleophiles. The reaction between activated furans and amines results in a distinct color change, discernable by the naked eye. UV/Vis absorption spectroscopy was utilized to monitor reactions in solution and determine detection limits. Additionally, solutions of MAF were useful as stains for thin layer chromatography and for monitoring solid‐phase synthesis of peptides and peptidomimetics. Finally, MAF was used to detect volatile amines released from fish samples, demonstrating potential for food spoilage applications.
Design of High Quality Chemical XOR Gates with Noise Reduction
Authors: Wood Mackenna L. , Domanskyi Sergii , Privman Vladimir 
Published: January 2017

AbstractWe describe a chemical XOR gate design that realizes gate‐response function with filtering properties. Such gate‐response function is flat (has small gradients) at and in the vicinity of all the four binary‐input logic points, resulting in analog noise suppression. The gate functioning involves cross‐reaction of the inputs represented by pairs of chemicals to produce a practically zero output when both are present and nearly equal. This cross‐reaction processing step is also designed to result in filtering at low output intensities by canceling out the inputs if one of the latter has low intensity compared with the other. The remaining inputs, which were not reacted away, are processed to produce the output XOR signal by chemical steps that result in filtering at large output signal intensities. We analyze the tradeoff resulting from filtering, which involves loss of signal intensity. We also discuss practical aspects of realizations of such XOR gates.
Indirect exposure to client trauma and the impact on trainee clinical psychologists: Secondary traumatic stress or vicarious traumatization?
Authors: Makadia Rakhee , Sabin‐Farrell Rachel , Turpin Graham 
Published: January 2017

ObjectivesThe study investigated the relationship between exposure to trauma work and well‐being (general psychological distress, trauma symptoms, and disrupted beliefs) in trainee clinical psychologists. It also assessed the contribution of individual and situational factors to well‐being.DesignA Web‐based survey was employed.MethodsThe survey comprised the General Health Questionnaire, Secondary Traumatic Stress Scale, Trauma and Attachment Belief Scale, Trauma Screening Questionnaire, and specific questions about exposure to trauma work and other individual and situational factors. The link to the online survey was sent via email to trainee clinical psychologists attending courses throughout the UKResultsFive hundred sixty‐four trainee clinical psychologists participated. Most trainees had a caseload of one to two trauma cases in the previous 6 months; the most common trauma being sexual abuse. Exposure to trauma work was not related to general psychological distress or disrupted beliefs but was a significant predictor of trauma symptoms. Situational factors contributed to the variance in trauma symptoms; level of stress of clinical work and quality of trauma training were significant predictors of trauma symptoms. Individual and situational factors were also found to be significant predictors of general psychological distress and disrupted beliefs.ConclusionsThis study provides support for secondary traumatic stress but lacks evidence to support belief changes in vicarious traumatization or a relationship between exposure to trauma work and general psychological distress. The measurement and validity of vicarious traumatization is discussed along with clinical, theoretical implications, and suggestions for future research.Practitioner Points

Secondary traumatic stress is a potential risk for trainee clinical psychologists.
Training courses should (a) focus on quality of trauma training as it may be protective; (b) advocate coping strategies to reduce stress of clinical work, as the level of stress of clinical work may contribute to trauma symptoms.
Limitations include

Exposure to trauma work only uniquely explained a small proportion of variance in trauma symptoms.
The study was cross‐sectional in nature therefore cannot imply causality.
BEfree: A new psychological program for binge eating that integrates psychoeducation, mindfulness, and compassion
Authors: Pinto‐Gouveia José , Carvalho Sérgio A. , Palmeira Lara , Castilho Paula , Duarte Cristiana , Ferreira Cláudia , Duarte Joana , Cunha Marina , Matos Marcela , Costa Joana 
Published: January 2017

BackgroundBinge eating disorder (BED) is associated with several psychological and medical problems, such as obesity. Approximately 30% of individuals seeking weight loss treatments present binge eating symptomatology. Moreover, current treatments for BED lack efficacy at follow‐up assessments. Developing mindfulness and self‐compassion seem to be beneficial in treating BED, although there is still room for improvement, which may include integrating these different but complimentary approaches. BEfree is the first program integrating psychoeducation‐, mindfulness‐, and compassion‐based components for treating women with binge eating and obesity.ObjectiveTo test the acceptability and efficacy up to 6‐month postintervention of a psychological program based on psychoeducation, mindfulness, and self‐compassion for obese or overweight women with BED.DesignA controlled longitudinal design was followed in order to compare results between BEfree (n = 19) and waiting list group (WL;n = 17) from preintervention to postintervention. Results from BEfree were compared from preintervention to 3‐ and 6‐month follow‐up.ResultsBEfree was effective in eliminating BED; in diminishing eating psychopathology, depression, shame and self‐criticism, body‐image psychological inflexibility, and body‐image cognitive fusion; and in improving obesity‐related quality of life and self‐compassion when compared to a WL control group. Results were maintained at 3‐ and 6‐month follow‐up. Finally, participants rated BEfree helpful for dealing with impulses and negative internal experiences.ConclusionsThese results seem to suggest the efficacy of BEfree and the benefit of integrating different components such as psychoeducation, mindfulness, and self‐compassion when treating BED in obese or overweight women.Key Practitioner MessageThe current study provides evidence of the acceptability of a psychoeducation, mindfulness, and compassion program for binge eating in obesity (BEfree);Developing mindfulness and self‐compassionate skills is an effective way of diminishing binge eating, eating psychopathology and depression, and increasing quality of life in women with obesity;Integrating psychoeducation, mindfulness, and compassion seem to be effective in diminishing binge eating, with results maintained up to 6‐month postintervention.
A Simple Zinc Catalyst for Carbamate Synthesis Directly from CO2
Authors: Zhang Qiao , Yuan Hao‐Yu , Fukaya Norihisa , Yasuda Hiroyuki , Choi Jun‐Chul 
Published: January 2017

AbstractSeveral zinc salts were employed as catalysts for the synthesis of carbamates directly from aromatic amines, CO2, and silicate esters. Zn(OAc)2 offered the best performance among the salts tested. The addition of an N‐donor ligand such as 1,10‐phenanthroline increased the yield. The best catalytic performance of Zn(OAc)2 can be explained by carboxylate‐assisted proton activation. The interaction between the substrate and the catalyst can be observed by chemical shifts in 1H and 15N NMR spectra. Isocyanate was a key intermediate, which was generated from amine and CO2. Silicate ester was finally converted to siloxane, which was determined by 29Si NMR. The commercially available catalyst system could be reused. The yield of isolated carbamate could reach up to 96 % with various substrates, and the catalytic reaction was amine‐selective in the presence of other functional groups.
Synthesis of Furandicarboxylic Acid Esters From Nonfood Feedstocks Without Concomitant Levulinic Acid Formation
Authors: van der Klis Frits , van Haveren Jacco , van Es Daan S. , Bitter Johannes H. 
Published: January 2017

Abstract5‐Hydroxymethylfurfural (HMF) is a versatile intermediate in biomass conversion pathways. However, the notoriously unstable nature of HMF imposes challenges to design selective routes to chemicals such as furan‐2,5‐dicarboxylic acid (FDCA). Here, a new strategy for obtaining furans is presented, bypassing the formation of the unstable HMF. Instead of starting with glucose/fructose and thus forming HMF as an intermediate, the new route starts from uronic acids, which are abundantly present in many agro residues such as sugar beet pulp, potato pulp, and citrus peels. Conversion of uronic acids, via ketoaldonic acids, to the intermediate formylfuroic acid (FFA) esters, and subsequently to FDCA esters, proceeds without formation of levulinic acid or insoluble humins. This new route provides an attractive strategy to valorize agricultural waste streams and a route to furanic building blocks without the co‐production of levulinic acid or humins.
Power optimization using optimal small cell arrangements in different deployment scenarios
Authors: Gupta Akhil , Jha Rakesh Kumar 
Published: January 2017

SummaryFor smooth transition from 4G to 5G, there is a need for optimizing the power in the wireless communication. In 5G, it is expected that the number of users will increase drastically that correspondingly increase the utilization of power in the transmitter and receiver sides. So researchers and academicians are now finding ways to optimize the power. Some optimizing methods like convex optimization are very helpful for optimized algorithm design. In this paper, a proposed mathematical approach for deployment of small cell access point is used for optimizing the power consumption in the massive multiple input and multiple output and small cell scenario. The new proposed mathematical approach will also help in deciding the optimal number of small cell access points and optimal location of these small cell access points for the particular deployment scenario like urban macro heterogeneous deployment scenario in the 3GPP LTE standard and different macro deployment scenario in the ITU‐R M.2135 standard like urban macro, suburban macro, and rural macro, for optimizing the power.
Cross‐layer technique for boosting base‐station anonymity in wireless sensor networks
Authors: Alsemairi Sami , Younis Mohamed 
Published: January 2017

SummaryA wireless sensor network (WSN) principally is composed of many sensor nodes and a single in situ base station (BS), which are randomly distributed in a given area of interest. These sensor nodes transmit their measurements to the BS over multihop wireless paths. In addition to collecting and processing the sensed data, the BS performs network management operations. Because of the importance of the BS to the WSN, it is the most attractive target of attacks for an adversary. Basically, the adversary opts to locate the BS and target it with denial‐of‐service attack to temporarily or indefinitely disrupt the WSN operation. The adversary can intercept the data packet transmissions and use traffic analysis techniques such as evidence theory to uncover the routing topology. To counter such an attack, this paper presents a novel technique for boosting the BS anonymity by grouping nodes into clusters and creating multiple mesh‐based routing topologies among the cluster heads (CHs). By applying the closed space‐filling curves such as the Moore curve, for forming a mesh, the CHs are offered a number of choices for disseminating aggregated data to the BS through inter‐CH paths. Then, the BS forwards the aggregated data as well so that it appears as one of the CHs. The simulation results confirm the effectiveness of the proposed technique in boosting the anonymity of the BS.
Crack willow changing riverine landscapes in Patagonia
Authors: Datri L. , Faggi A. , Gallo L. 
Published: January 2017

AbstractIn Patagonia (Argentina) in recent decades, the exotic species and hybrids of Salix alba–Salix fragilis complex has spread over wide areas along watercourses, taking advantage of it is sexually and vegetatively propagation. It outcompetes with native vegetation, facilitated by stochastic events related to large floods of long‐lasting duration higher than the average maximum of 186 m3/s for more than a day. We analysed the exotic willow's increase along the braiding Azul River, and the hydrological regime between 1966 and 2012. We evaluated the links between regime and tree density over time using dendrochronological data. Results showed an increase of the forest's cover from 2.1% to 70.8% over the last 46 years. The densities of exotic willows grew exponentially between 1966 and 1973, during a period which was free of higher floods. The initial native populations declined as willow's population increased. Up to 1973, there was an increase in the native populations too. Then from 1974 on, the willow showed a gradual growth coupled with a decline in the native trees. Up to 1977, the willow expansion could be linked to an extreme flood that reached 392 m3/s (210.75%) greater than the average of the maximum flows). We concluded that plant succession in the Azul River follows a “Red Queen” effect whereby the exotic willow and native trees repeatedly reorganized the system after pulses and periods of extreme flooding events.
Constant‐ductility response spectra for sequential earthquake and tsunami loading
Authors: Scott Michael H. , Mason H. Benjamin 
Published: January 2017

SummarySimplified approaches for examining structural system response under sequential earthquake and tsunami loading are helpful for understanding response trends. To aid understanding, nonlinear (constant‐ductility) response spectra are developed for elastoplastic single degree of freedom systems subjected to seismic loads followed by hydrodynamic tsunami loads. The forcing function is composed of long‐duration earthquake motion concatenated with a range of tsunami hydrodynamic forces that are proportional to the pseudo‐spectral acceleration produced by the earthquake motion. The constant‐ductility spectra are thus constructed for scenarios where the loading imposed by one hazard is not dominant over the other. The spectra and basic intensity measures indicate that the amplification of response for sequential earthquake and tsunami loading over the earthquake only case is most significant for systems with long natural periods and high‐ductility capacity under seismic loading. Copyright © 2017 John Wiley & Sons, Ltd.
Lichen sclerosus and risk of cancer
Authors: Halonen Pia , Jakobsson Maija , Heikinheimo Oskari , Riska Annika , Gissler Mika , Pukkala Eero 
Published: January 2017

Malignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population‐based Finnish Cancer Registry data to further study this connection.We identified all women with the diagnosis of LS (n = 7,616) listed in the Finnish Hospital Discharge Registry from 1970 to 2012. The cohort was followed through the Finnish Cancer Registry for subsequent cancer diagnoses until 2014. Standardized incidence ratios (SIRs) were calculated for different cancers by dividing the observed numbers of cancers by expected ones. The expected numbers were based on national cancer incidence rates.During the follow‐up period, we found 812 cancers among patients with LS (SIR: 1.13, 95% CI 1.05–1.21). LS was associated with an increased risk of vulvar (182 cases, SIR: 33.6, 95% CI 28.9–38.6) and vaginal cancer (4 cases, SIR: 3.69, 95% CI 1.01–9.44). The risk of cancers of the uterine cervix and lung was significantly decreased.LS is associated with an increased risk for vulvar and vaginal cancer. These data are important when designing the care of women diagnosed with LS.
Comparison of different enzyme‐linked immunosorbent assay methods for avidity determination of antiphospholipid antibodies
Authors: Fialová Lenka , Petráčková Milada , Kuchař Oliver 
Published: January 2017

BackgroundAvidity of antiphospholipid antibodies may be clinically useful as a valuable additional characteristic. The aim of this study was to compare several ELISA modifications with different chaotropic agents and calculation of avidity indices for the determination of anticardiolipin antibody (aCL) avidity.MethodsWe examined 28 serum samples with positive IgG aCL by adapted ELISA using various concentrations of urea and sodium chloride as chaotropic agents and different dilution of sera. We tested these conditions of ELISA—a single diluted serum sample with fixed concentration of a chaotrope and a serially diluted serum in the constant concentration of a chaotropic agent.ResultsWe demonstrated that ELISA method for avidity determination based on a single dilution of serum in the presence of fixed concentration of chaotrope is convenient for determination of IgG aCL antibody avidity. Concentrations 6 and 8 mol/L of urea or 1 and 2 mol/L of NaCl were suitable for sufficient dissociation of immune complexes during ELISA procedure.ConclusionThis way was in good agreement with more demanding procedures. Both urea and sodium chloride may be used as chaotropic agents. Reference values of avidity indices essential for interpretation of patients’ results must be established individually for distinct assay conditions.
Skin regeneration stimulation: the role of PCL‐platelet gel nanofibrous scaffold
Authors: Ranjbarvan Parviz , Soleimani Masoud , Samadi Kuchaksaraei Ali , Ai Jafar , Faridi Majidi Reza , Verdi Javad 
Published: January 2017

AbstractSkin is the largest organ of the human body. Thus far, tissue engineering of skin has developed rapidly and has used many types of growth factors and nanofibrous scaffolds. In this study, we differentiated neonate keratinocytes for epithelialization on the polycaprolactone‐Platelet gel (PCL‐PG) scaffold. Fabricated PCL nanofibers prepared by electrospinning technology and coated by platelet gel. Subsequently, the structure of the scaffold was evaluated by SEM, FTIR‐ATR, contact angle and tensile test assays. After seeding the neonate keratinocytes on neat PCL and PCL‐PG scaffolds, the epidermal maturation was tested by detecting cytokeratin 10 and loricrin determinants by immunocytochemistry; moreover, keratinocyte genes such as keratin 14, keratin 10, and Involucrin were investigated by real‐time PCR. The results of MTT assay indicated an increase in cell viability and cell proliferation of neonate keratinocytes on PCL‐PG nanofiber scaffolds compared with PCL. RT‐PCR and immunocytochemical analysis showed better cell differentiation on the PCL‐PG scaffolds than neat PCL. Furthermore, SEM microscopy images demonstrated that neo‐keratinocytes enhance adhesion and proliferation on PCL‐PG nanofiber scaffolds. We found that PG increases biocompatibility and wettability of scaffold, cell adhesion, and expression of keratinocyte markers. Overall, this procedure is recommended to be employed in skin tissue engineering and wounds healing.
Atmospheric circulation patterns associated with monthly and daily temperature and precipitation extremes in Alaska
Authors: Bieniek Peter A. , Walsh John E. 
Published: January 2017

ABSTRACTThis study presents (1) the temporal variations and trends of monthly and daily temperature and precipitation extremes in Alaska, and (2) the synoptic‐scale circulation patterns associated with these extremes. The analysis is based on daily station observations of maximum temperature, minimum temperature and precipitation from 1948–2012 as well as monthly average temperatures and precipitation from 1920–2012 from 13 Alaska climate divisions. The frequencies of daily and monthly temperature extremes show variability and trends over the past 50–90 years consistent with a warming climate in Alaska. This warming is superimposed on low‐frequency variability attributed to the Pacific Decadal Oscillation. Unlike the temperature extremes, occurrences of heavy‐precipitation extremes do not display a coherent signal through time. The changes do not appear to be linked with an overall increase in the variance of temperature or precipitation. Composite analysis of sea level pressure (SLP) anomalies associated with a representative sample of different daily and monthly temperature extremes across Alaska shows that temperature and moisture advection, subject to topographic and coastal influences, is a key driver of these events. Composite SLP fields for daily and monthly extremes are similar, especially in winter, indicating that monthly extremes represent the recurrence of daily extreme patterns during those extreme months. The SLP anomalies were also often reduced in magnitude in the summer events compared with winter, consistent with the lower variance of temperature and SLP during summer.
A novel algorithm for selective current limit used in AMOLED panel
Authors: Huang Chengqiang , Zhang Qi , Wang Hui , Feng Songlin 
Published: January 2017

AbstractA selective current limit algorithm based on color space conversion is proposed in this paper. There are mainly two advantages for this algorithm. Firstly, only the luminance component Y is decreased, and the color component Cb or Cr is not changed; thus, the color distortion is avoided in the process of current limit. Secondly, the current of pixels with high luminance is limited while that of those pixels with low luminance is not, which means current limit is executed selectively. For the same value of mean square error, the simulation results show that the ratio of pixels with high luminance of the image processed by the proposed algorithm is zero, and that processed by the net power control and the algorithm based on color space conversion is 0.081 and 0.0854, respectively. This algorithm is implemented on a field‐programmable gate array to drive the image display on the AMOLED panel.