bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular and phenotypic characterization of the vancomycin-resistant gene in bacterial isolates acquired from catheter tips
Authors: Siddiqui Samra , Saeed Mohd , Faisal Syed Mohd , Akhtar Asma , Sarim Khan Mohd , Khan Mahvish , Ahmad Israr , Ahmad Irfan 
Published: January 2018

Gram-positive bacteria, particularly Staphylococcus aureus is a significant pathogen, not only in the hospital setting but the community also. S. aureus is a major cause of serious hospital and community-acquired infections, particularly in the colonized individuals. The emergence of vancomycin-resistant S. aureus (VRSA) strains has led to global concerns about treatments for staphylococcal infections. Until now, few strains of VRSA have been reported worldwide. The conventional disk diffusion method for determination of vancomycin sensitivity often misclassifies intermediately susceptible isolates to fully sensitive. However, non-automated minimum inhibitory concentration (MIC) detection methods are the gold standards. Hence there is a dire need of some advanced methods for rapid detection of VRSA strains. In the present study, Gram-positive clinical isolates were collected from different wards of K.G.M.U. Hospital, among them, 12 bacterial isolates were identified as Staphylococcus aureus and 18 isolates as Klebsiella spp. Genomic DNA of S. aureus was isolated and used as template in PCR for detection of the presence of van A and van X gene based on a given protocol. Nosocomial infections have an impact on morbidity and probably on mortality as well, and pose a significant economic burden. Rapid molecular identification of antibiotic-resistant strains undoubtedly helps to prevent the hospital-induced infections.
Regulation of signal transduction cascades by Pterostilbenes in different cancers: Is it a death knell for oncogenic pathways
Authors: Butt Ghazala , Attar Rukset , Tabassum Sobia , Aras Aliye , Qadir Muhammad Imran , Ozbey Ulku , Alaaeddine Nada , Ozcelik Beraat , Farooqi Ammad Ahmad 
Published: January 2018

Interdisciplinary research has revolutionized the field of medicine and we have witnessed exponential increase in the high-impact research in past few decades. However, the road to this burgeoning research field is obstacle-ridden because of intratumor heterogeneity, loss of apoptosis and dysregulation of spatio-temporally controlled signaling pathways. Ground-breaking findings obtained through genetic, genomic and proteomic studies have considerably improved our concepts related to the complexity of protein network and excitingly, discovery of miRNAs has added another layer of intricacy to quantitatively regulated gene networks. In this review, we chronicle the milestone achievements and discuss how Pterostilbenes effectively regulated different cellular pathways. We have provided detailed mechanistic insights related to regulation of JAK-STAT signaling, Notch pathway, Wnt mediated intracellular signaling by pterostilbene. Underlying mechanisms about regulation of PI3K/AKT and MAPK pathways by pterostilbene in different cancers. Regulation of Metastasis-associated protein 1 (MTA1) proteins and Human telomerase reverse transcriptase (hTERT) in cancer cells by pterostilbene. Pterostilbene has also been reported to modulate the expression of various oncogenic and tumor suppressor microRNAs in cancer cells. Better and sharper comprehension of the concepts associated with the modes of action of pterostilbene in different cancers will be useful in identification of cancers which can be efficiently targeted by pterostilbene.
Astemizole inhibits cell proliferation in human prostate tumorigenic cells expressing ether í -go-go-1 potassium channels
Authors: Bernal-Ramos Gloria , Hernández-Gallegos Elisabeth , Vera Eunice , Chávez-López Marí­a de Guadalupe , Zúñiga-Garcí­a Violeta , Sánchez-Pérez Yesennia , Garrido Efraí­n , Camacho Javier 
Published: January 2018

Prostate cancer (PC) is the main cause of cancer mortality in men worldwide. Therefore, novel treatments for PC are needed. Ether í -go-go-1 (Eag1) potassium channels display oncogenic properties, and have been suggested as early tumor markers and therapeutic targets for different cancers. These channels are overexpressed in many human tumors including PC. Astemizole targets several molecules involved in cancer including Eag1 channels, histamine receptors and ABC transporters. Here we studied Eag1 mRNA expression and protein levels in the non-tumorigenic and non-invasive human prostate RWPE-1 cell line, and in the tumorigenic and highly invasive human prostate WPE1-NB26 cell lines. The effect of astemizole on cell proliferation and apoptosis was also studied. The human prostate cell lines RWPE-1 and WPE1-NB26 were cultured following the provider´s instructions. Eag1 mRNA expression and protein levels were studied by real time RT-PCR and immunocytochemistry, respectively. Cell proliferation and apoptosis were studied by a fluorescence AlamarBlue® assay and flow cytometry, respectively. No difference in Eag1 mRNA expression was observed between the cell lines. However, high Eag1 protein levels were observed in the invasive WPE1-NB26 cells, in contrast to the weak protein expression in RWPE-1 cells. Accordingly, astemizole decreased cell proliferation at nanomolar concentrations only in the invasive WPE1-NB26 cells. Our results suggest that astemizole may have clinical relevance for prostate cancer treatment in patients with high Eag1 protein levels.
Invisible guests: A sound installation in a Montréal community restaurant
Authors: Binette Melanie 
Published: January 2018

Invité.e.s invisibles (Invisible Guests) is a sound installation created in collaboration with a community restaurant that provides affordable meals to a disadvantaged population in Hochelaga-Maisonneuve, a former industrial neighbourhood in Montréal. Recorded conversations were made available for patrons who were eating alone, with the hope of breaking the social isolation experienced by some. By listening to the conversations on headphones as they were eating, patrons could virtually encounter other members of the community and engage with their concerns through hearing their stories. This is a first step toward group socialization for those who find it hard to communicate in person, and yet are eager to "share" their meals. Invité.e.s invisibles est une installation sonore créée en collaboration avec un restaurant communautaire qui offre des repas abordables à une population défavorisée dans Hochelaga-Maisonneuve, un ancien quartier industriel de Montréal. Des conversations enregistrées étaient mises à la disposition de personnes venant y manger seules, dans l'espoir de rompre avec l'isolation que certain.e.s peuvent ressentir. Les conversations étaient diffusées sur des écouteurs que les gens pouvaient porter tout en prenant leur repas, ce qui leur permettait de rencontrer virtuellement d'autres membres de la communauté. En écoutant leurs récits, elles et ils pouvaient s'y reconnaître et se sentir investi.e.s des mêmes préoccupations. Cette installation pouvait servir de première étape vers la socialisation pour celles et ceux qui ont de la difficulté à communiquer en personne, mais qui désirent néanmoins «partager» leurs repas. Photo Credit:Invisible Guests. A participant listens to the sound installation at Le Chic Resto Pop. Photo par Patrick Ma. 2015. / Invité.e.s invisibles. Un participant à l'écoute de l'installation sonore au Chic Resto Pop. Photo par Patrick Ma. 2015.
Prevention of Dumping Practice in Asean Free Trade China Free Trade Area (Acfta) Regarding Government Regulation Number 34 Year 2011
Authors: Anggraeni Dewi 
Published: January 2018

The practice of dumping is the practice of selling imported goods below the normal price of domestic products. This governmental regulation is logical consequence in implementing the dumping regulation on the framework of GATT. Govermental regulation No. 34 Year 2011 on Antidumping and Safeguard Measures Trade does not regulate the substance in detail. The Government Regulation more regulates about procedures. Whereas in Anti Dumping Agreement (ADA) is arranged detail. Currently, foreign products are easy to find in various shopping centers, especially imported goods from China, China's export activities to Indonesia unstoppable since the existing of ACFTA agreement. In the free trade dumping practice and allegation of dumping practice are problems that received big attention by various countries relating effort to realize fair trade practice Praktik dumping merupakan praktik penjualan barang impor di bawah harga normal produk domestik. PP ini wujud konsekuensi logis pemerintah Indonesia dalam melaksanakan ketentuan dumping dalam rangka GATT. PP No. 34 Tahun 2011 Tentang Tindakan Antidumping, Tindakan Imbalan dan Tindakan Pengamanan Perdagangan tidak mengatur substansinya secara detail. Peraturan Pemerintah tersebut lebih mengatur tentang prosedur. Padahal dalam Anti Dumping Agreement (ADA) diatur sedemikian detail. Saat ini produk-produk asing mudah sekali kita temukan diberbagai pusat pembelanjaan, terutama barang-barang impor dari Negara China, kegiatan ekspor China ke Indonesia semakin tidak terbendung tatkala sejak berlakunya perjanjian ACFTA.. Dalam perdagangan bebas praktik dumping dan tuduhan praktik dumping merupakan persoalan yang mendapat perhatian sangat besar oleh berbagai negara karena berkaitan dengan usaha untuk mewujudkan praktik dagang yang adil. DOI: 10.15408/jch.v5i1.6583
Magyarországi orvostanhallgatók külföldi munkavállalási szándékai
Authors: Győrffy Zsuzsa , Szél Zsuzsanna 
Published: January 2018

Abstract: Introduction: Migration, drop-out and ageing of physicians are the most important challenges of the 21st century healthcare system. The young doctors’ willingness to work abroad will become a decisive issue of the human resources of healthcare in the following decades. Aim: To explore the willingness of migration among medical university students. Method: Quantitative and qualitative online survey of students from 4 Hungarian medical universities (n = 530). In the present study we investigated only the 5th- and 6th- year students’ answers (n = 165). Results: 40% of students plan to work abroad, mostly for a 2–5 year timeframe. The motivation of working abroad are the following: work conditions of medical system, inadequate pay and general living conditions in Hungary. The content analysis of open answers showed that the willingness to return depends mainly on family reasons and the objective working conditions (infrastructure, pay, abolition of the gratuity system). An equally important factor is the evolution of work culture. Conclusions: As opposed to previous studies, our results indicate a more prevalent willingness to work abroad while an unambiguous return is only possible with a drastic change in the healthcare system. Orv Hetil. 2018; 159(1): 31–37.
Új távlatok a végbélrák sebészetében: Transanalis teljes mesorectum excisio. Kezdeti eredményeink
Authors: Papp Géza , Bánky Balázs , Lakatos Miklós , Svastics Imre , Burány Ákos , Bursics Attila 
Published: January 2018

Abstract: Introduction: Colorectal cancer is the second most frequent cause of oncologic mortality. Its key prognostic factors are operability and surgical quality. Total mesorectal excision is the gold standard of rectal cancer surgery, however, it is hardly achievable with the laparoscopic technique in a number of cases due to anatomical issues. Transanal total mesorectal excision (TaTME) is a new operative concept, which may address this technical problem. Aim: We aimed to present the initial Hungarian experiences with the new technique. Method: Retrospective analysis of clinical data of the first year case series at two Hungarian centers initiating the technique. Results: A total of 17 transanal total mesorectal excision (TaTME) operations were performed at two centers. Major perioperative complications happened in two cases. There was no 30-day mortality. Conclusions: Early Hungarian experiences with transanal total mesorectal excision (TaTME) give hope of a brand new era of rectal cancer surgery. Orv Hetil. 2018; 159(1): 16–22.
Las cofradías españolas en la Edad Moderna desde una óptica social. Tres décadas de avance historiográfico
Authors: Arias de Saavedra Alías Inmaculada , López-Guadalupe Muñoz Miguel Luis 
Published: January 2018

RESUMENNo hay fenómeno asociativo más extendido en la España del Antiguo Régimen que las cofradías y hermandades. En consecuencia, su dimensión social ha merecido el análisis histórico en las últimas décadas, incidiendo en aspectos esenciales de su naturaleza: la solidaridad grupal y el mutualismo que despliegan, y el culto público y la multiplicación de fiestas que fomentan. Todo ello desde un indudable afán de autonomía difícil de mantener. A falta de obras de conjunto, la bibliografía es hoy muy abundante y a la vez dispersa. Esa realidad social y la actuación de la autoridad real y eclesiástica sobre el ámbito cofrade se analizan en este artículo, evidenciando los avances en el conocimiento, así como los aspectos que merecen una mayor actividad investigadora.PALABRAS CLAVECofradía, Hermandad, Religiosidad, Fiesta, Mutualismo, Iglesia, Regalismo. TITLEThe Spanish brotherhoods during the Modern Age from a social point of view. Three decades of historiographic progressABSTRACTNo associative phenomenon was more extended during the Ancient Regime in Spain than the brotherhoods. As a consequence, its social dimension deserves the historical analysis it has received these last decades, focusing on the essential aspects of their nature: the group solidarity and the mutual support they demonstrated, the public worship and the numerous festivities that these associations promoted. All these, from an unquestionable eagerness for autonomy that was difficult to maintain. Although there is a lack of complete, cohesive works, nowadays the bibliography on confraternities and brotherhoods can be described as abundant and at the same time scattered. This social reality and the intervention from the royal and ecclesiastical authority on the brotherhood sphere, is analyzed during this particular article, evidencing the advances in knowledge as well as the aspects that deserve a greater research activity.KEY WORDSBrotherhood, Confraternity, Religiousness, Festivity, Mutuality, Church, Regalism.
Biblia e Ilustración en la crítica de la religiosidad barroca
Authors: Mestre Sanchís Antonio 
Published: January 2018

RESUMENLos católicos ilustrados se preocuparon por adaptar su manera de vivir el cristianismo a su forma cultural. De ahí que criticaran la excesiva religiosidad exterior, el sermón conceptista y que exigieran mayor rigor moral, al tiempo que pedían la libertad de leer la Biblia en lengua vulgar.PALABRAS CLAVEBiblia, Ilustración, reforma eclesiástica, sermón, jansenismo, masonería. TITLEBible and Enlightenment in the Baroque religiosity critiqueABSTRACTEnlightened Catholics were concerned with adapting their way of life to the cultural forms of their time. They criticized the excessive external religiosity and the conceptist preaching and demanded more moral rigor, at the same time that asked for freedom to read Holy Bible in vulgar language.KEY WORDSBaroque religiosity, Holy Bible, Conceptist Preaching, Jansenism, Masonry.
Three-port versus four-port laparoscopic cholecystectomy: a comparative study at a tertiary care centre in North India
Authors: Kumar Peeyush , Rana Anil K. S. 
Published: January 2018

Background: Improvement of Laparoscopic Cholecystectomy (LC) technique in terms of reduction in size and number of ports is being tried to improve patient satisfaction and outcome. Present study was conducted to evaluate and compare the safety outcome and advantages of three-port and four-port LC. Methods: This prospective study included 90 patients presenting with symptomatic gall stone disease or gall bladder polyp more than 1cm at base. Patients with jaundice and choledocholithiasis were excluded. Patients were divided into two groups: A and B, who underwent three-port and four-port LC respectively. Outcomes of the two groups were assessed and compared in terms of duration of surgery, intra-operative and post-operative variables including rate and nature of complications, conversion rates, post-operative pain, duration of hospital stay, return to work and cosmetic outcome.Results: Statistically significant difference was found between the two groups in terms of Visual Analogue Score for pain at 6 and 24 hours, analgesic requirement, duration of hospital stay and return to work; all being less in the three- port LC group. Cosmetic outcome as perceived by patients was also better in the three-port group. Results of other variables were comparable in the two groups. Conclusions: Three-port procedure is safe and appears to be more cost effective than four-port LC. If LC is performed by an experienced surgeon, it can be started with three ports, if required, a fourth port can be inserted.
Outcome of Ilizarov assisted ankle arthrodesis
Authors: Chattopadhyay Priyajit , Banka Paras Kumar , Debnath Anindya , Kumar Sanjay 
Published: January 2018

Background: Among the various techniques used for ankle arthrodesis, Ilizarov technique has various advantages along with the potential for treating complex and failed cases.Methods: Eleven cases were undertaken for ankle arthrodesis using the Ilizarov fixator. Two rings were applied along the tibia and one at the talus/calcaneum. The articular cartilage was denuded, and dynamic compression applied. The clinical, functional and radiological outcome were evaluated. The goal was a stable fusion with a well aligned foot.Results: The mean follow-up period was 95 weeks. Fusion was achieved in all cases with no major complication. Only one case had a residual deformity. The average time interval for the ankle fusion was 140.8±25.7 days. The postoperative modified American Orthopaedic Foot and Ankle Society (AOFAS) Hindfoot score was 67.5±9.6 points.Conclusions: Ilizarov assisted ankle arthrodesis aids in early weight bearing, better alignment, and has good functional outcomes even in cases with previously failed procedures. It has the advantage of postoperative readjustment of the arthrodesis without the need of any second procedure with no major complications.
A Study of HbA1c, fasting and 2 hour plasma glucose levels in current smokers presenting at a tertiary care hospital in North India
Authors: Verma Niket 
Published: January 2018

Background: There is a concern that smokers are at increased risk of diabetes and this association has received surprisingly little attention. This study aims to study the relationship of smoking with three glycaemic variables (HbA1c, fasting and 2 hour post prandial plasma glucose levels) in current smokers and describe the potential impact of smoking in the context of screening for diabetes by using one of these glycaemic variables.Methods: 150 patients attending the OPD of Santosh Medical College were part of this Cross sectional population based study. One hundred were smokers and fifty non-smokers and non-diabetics. All participants were subjected to fasting plasma glucose level, 2 hour plasma glucose level and HbA1c testing.Results: Mean values of all three variables are substantially higher in smokers as compared to non-smokers. HbA1c levels show an increasing trend with increasing age among both groups. Mean plasma glucose levels show increasing values with increasing age but the trend is not uniform. Among females, only HbA1c levels whereas among males all three variables show a strong correlation with smoking. No correlation was observed between the number of cigarettes smoked daily or smoking index and the glycaemic variables. All variables show an increasing trend as the number of years of smoking increases.Conclusions: A higher prevalence of diabetes is seen in current smokers when we consider HbA1c levels indicating the beneficial effect of using HbA1c levels for identifying current smokers at risk of diabetes mellitus.
Analiza ekspertyzy osmologicznej - metodologia i wartość dowodowa w postępowaniu karnym
Authors: Jędrzejczyk Michał 
Published: January 2018

Artykuł przedstawia analizę istoty oraz procesu ekspertyzy osmologicznej opartej na Metodyce Badań Osmologicznych Centralnego Laboratorium Kryminalistycznego Policji. W pracy przedstawione zostały aktualne metody pobierania śladów, materiałów porównawczych oraz sposoby i stosowania celem identyfikacji potencjalnego sprawcy czynu zabronionego. Wskazane zostało również, że ze względu na swój niepewny i podatny na uchybienia proceduralne charakter ekspertyzy osmologicznej, dowód z niej wywiedziony nie powinien być jedynym w postępowaniu. Ponadto, w odniesieniu do dowodu z ekspertyzy osmologicznej wprowadzone i wyjaśnione zostały definicja i charakterystyka dowodu naukowego.
Ustawa Prawo o ustroju sądów powszechnych z 2001 r. – analiza wybranych elementów nowelizacji z 12.7.2017 r.
Authors: Parchała Ernestyna 
Published: January 2018

Artykuł analizuje wybrane zmiany wprowadzone do ustawy - Prawo o ustroju sądów powszechnych (Dz. U. Nr 98, poz. 1070, ze zm.) nowelizacją z 12.7.2017 r. W tekście opisano najważniejsze założenia wspomnianej nowelizacji oraz porównano je z poprzednim stanem prawnym. Analizie zostały poddane trzy kategorie zmian: struktura sądownictwa powszechnego, kwestia nadzoru nad sądami i samymi sędziami, a także wąsko pojęte funkcjonowanie sądów. W każdej z tych kategorii ustawodawca proponuje istotne zmiany, między innymi losowe przydzielanie spraw sędziom, modyfikacje trybu powoływania i odwoływania prezesów oraz wiceprezesówsądów czy rozszerzenie obowiązku składania rocznej informacji o działalności sądu. Autorka opisuje znowelizowane przepisy prawne oraz próbuje przewidzieć ich możliwe skutki dla funkcjonowania polskiego systemu sądownictwa powszechnego.
A Modern Historical Perspective of Schroth Scoliosis Rehabilitation and Corrective Bracing Techniques for Idiopathic Scoliosis
Authors: Moramarco Kathryn , Borysov Maksym 
Published: January 2018

The treatment of scoliosis has a long history dating back to Hippocrates and his luxation table. In recent history, conservative rehabilitation treatment methods have come and gone. Some have had more longevity than others and currently there are only a handful of these “schools” for rehabilitation in existence.What is important to note in this twenty-first century world is that any approach to bracing or scoliosis rehabilitation must strive for a correction effect and be as user-friendly as possible. Patients look to achieve some measure of success, whether it be halted Cobb angle, improved breathing function, decreased rotation, or postural improvementviatrunk symmetry.Katharina Schroth created her method in 1921 as a result of self-analysis of her own imperfect scoliotic torso and the effect on it as she altered her breathing patterns. It was from these observations and self-experimentation that she devised her rotational angular breathing method. Subsequently, the Schroth method evolved under the leadership of her daughter, Christa Lehnert-Schroth P.T., and grandson, Dr. Hans-Rudolf Weiss. Collaboration with Dr. Jacques Chêneau led to a new Schroth method compatible scoliosis bracing approach. The most recent advancement of Chêneau bracing is the Gensingen Brace® (GBW). Gensingen braces have an asymmetric design and rely on Schroth principles of correction in a smaller, lighter, more wearer-friendly brace. Each brace is designed to be a complementary supportive orthosis. It may be used independently, or in conjunction with Schroth exercise protocols.