bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavioral-Social Adjustment of Adolescents with Craniofacial Microsomia
Authors: Wallace Erin R. , Collett Brent R. , Heike Carrie L. , Werler Martha M. , Speltz Matthew L. 
Published: January 2018

Objective: The objective was to assess differences in psychosocial adjustment between adolescents with and without craniofacial microsomia (CFM). Design: This is a case-control follow-up study in adolescents with and without CFM. Setting: Participants were originally recruited as infants from 26 cities across the United States and Canada. Participants: Participants included 142 adolescents with CFM (cases) and 316 peers without CFM (controls), their caregivers, and their teachers. Main Outcome Measures: Social and behavior measures from the Achenbach System of Empirically Based Assessments (ASEBA), the PedsQL: Core Version, and the Children’s Communication Checklist–2nd edition (CCC-2) were used. Linear regression was used to estimate case-control differences and corresponding standardized effect sizes (ES) and 95% confidence intervals after adjustment for sociodemographic confounds. We also examined case-control differences by facial phenotype and hearing status. Results: The magnitude and direction of case-control differences varied across assessment and respondent, but were generally modest (ES = –0.4 to 0.02, P values ranged from .003 to .85). There was little evidence for variation in case-control differences across different facial phenotypes or as a function of hearing status. Conclusions: Our results suggest that in spite of multiple risk factors, adolescents with CFM exhibit behavior problems no more frequently than their peers without CFM. Future studies of individuals with CFM should focus on resilience and social coping mechanisms, in addition to maladjustment.
Discontinuation of Postoperative Prophylactic Antibiotics After Noninstrumented Spinal Surgery: Results of a Quality Improvement Project
Authors: Lewis Ariane , Lin Jessica , James Herbert , Hill Travis C. , Sen Rajeev , Pacione Donato 
Published: January 2018

Background: Numerous medical society guidelines recommend discontinuation of antibiotics at a maximum of 24 hours after noninstrumented spinal surgery, even when a drain is left in place. As a result of these recommendations, our institution’s Neurosurgery Quality Improvement Committee decided to stop administering prolonged prophylactic systemic antibiotics (PPSAs) to patients with drains after noninstrumented spinal surgery. Methods: We retrospectively reviewed data for patients who had noninstrumented spinal surgery performed by a neurosurgeon at our institution between December 2012 and July 2014 (PPSA period) and December 2014 and July 2016 (non-PPSA period) and had a drain left in place postoperatively. In the PPSA period, patients received antibiotics until drain removal. In the non-PPSA period, patients received antibiotics for a maximum of 24 hours. Results: We identified 58 patients in the PPSA period and 55 in the non-PPSA period. Discontinuation of PPSAs resulted in a nonsignificant increase in the frequency of surgical site infections (SSIs; 0% in the PPSA period vs 4% in the non-PPSA period; P = .24). Conclusion: After discontinuing PPSAs for patients with noninstrumented spinal procedures, as is recommended for quality improvement, we saw a nonsignificant increase in our rate of SSIs. Further monitoring of this population is warranted.
Acromioclavicular joint disruptions: A comparison of two surgical approaches ‘hook’ and ‘rope’
Authors: Athar MS , Ashwood Neil , Arealis Georgios , Hamlet Mark , Salt Emma 
Published: January 2018

Introduction: Acromioclavicular joint injuries are common shoulder girdle injuries most commonly resulting from a direct blow to the acromion with the arm adducted. Type-I or type-II acromioclavicular joint injuries can be managed with sling immobilization, early shoulder motion, and physiotherapy. The management of type-III injuries remains controversial and is individualized. Type IV and V injuries should be treated surgically. A myriad of surgical techniques for the management of acromioclavicular joint injuries have been reported. Methods: We present a comparative study of 76 patients treated with two most common modalities of treatment for AC joint disruption and that is Hook plate stabilisation (n=52) or arthroscopically assisted tight rope stabilisation (n=24). The primary objective was to establish whether hook plate stabilization was superior compared to arthroscopic tight rope fixation in reducing pain and increasing function in the short-term and long-term for patients with AC joint disruptions III-IV. We also wanted to assess how quickly patients returned to their work/job. It was a prospective study, we included all the patients operated between 2008 and 2015 for AC joint disruption by the two shoulder surgeons of our department. All patients followed a strict physiotherapy protocol and were assessed at 6 weeks, 3 months and 12 months. We used the Harm and cost criteria of assessment and the patient specific functional outcome scores. Results: Both modalities of treatment have high patient satisfaction rate, return to work is faster in tight rope group but after a year both group of patients returned to their premorbid state. Removal of hook plate is not mandatory and lysis of acromion is rare (1% in our series). Conclusion: Despite the fact that both methods yielded similar results and have statistically similar number of complications, the type of postoperative complications was different between groups. The plate group had more postoperative pain and worse function but both aspects improved after plate removal. The rope group had more complex complications including deep infection and recurrence of deformity and fracture. These differences should be taken into consideration when consenting the patient regarding possible treatment.
Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies
Authors: Drazer Michael W. , Kadri Sabah , Sukhanova Madina , Patil Sushant A. , West Allison H. , Feurstein Simone , Calderon Dalein A. , Jones Matthew F. , Weipert Caroline M. , Daugherty Christopher K. , Ceballos-López Adrián A. , Raca Gordana , Lingen Mark W. , Li Zejuan , Segal Jeremy P. , Churpek Jane E. , Godley Lucy A. 
Published: January 2018

Key Points
NGS-based prognostic panels may identify individuals at risk for HHMs despite not being designed for this purpose. Variant allele frequency >0.4 and gene of interest may be predictive of germ line origin.
A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia
Authors: Chen Yiran , Xie Xiaoling , Wu Anqin , Wang Lei , Hu Yuxing , Zhang Honghao , Li Yuhua 
Published: January 2018

Abstract
Background
Oncogenic roles of epidermal growth factor receptor pathway substrate no.8 (EPS8) have been widely reported in various tumors, making targeting of EPS8 an appealing prospect. Here, we describe the role of EPS8 in acute myeloid leukemia (AML) and consider the potential of EPS8 as an anti-AML target. Nuclear localization signal (NLS) residues of tumor-associated proteins are crucial for cell cycle progression, and specific inhibitors derived from the NLS have inhibitory effect on cancer cells. The NLS in EPS8 has potential as a specific anti-AML target.

Methods
Gene Expression Omnibus expression profiles of AML patients were used to test associations between EPS8 expression and AML patient outcome. The biological characteristics of AML cells after EPS8 knockdown were analyzed in vitro and in vivo. A specific peptide (CP-EPS8-NLS) derived from the NLS of EPS8 (amino acids 298–310) was synthesized, and the anti-AML effects of CP-EPS8-NLS were analyzed in cancer cells and in xenograft models. Mutated CP-EPS8-NLS and penetratin served as controls.

Results
We observed that elevated EPS8 expression in AML patients is associated with poor outcome. Knockdown of EPS8 significantly suppressed the survival of AML cells in vitro and in vivo. CP-EPS8-NLS interfered with EPS8-associated signaling and consequently exerted anti-AML activity. Importantly, CP-EPS8-NLS displayed anti-AML activity in various AML cell types, with diminished activity in PBMCs. CP-ESP8-NLS suppressed U937 cell proliferation, and injection of CP-EPS8-NLS exerted potent antitumor activity in the xenograft tumor models. A synergistic effect of CP-EPS8-NLS and chemotherapeutic agents was also observed in vitro and in vivo. Mechanistically, treatment of various AML cells with CP-EPS8-NLS downregulated the expression of EPS8 and its downstream pathways.

Conclusions
The function of CP-EPS8-NLS is explained by the presence of a NLS in EPS8, which has been shown to induce nuclear translocation, consequently resulting in EPS8 overexpression. These results indicate that EPS8 is a potential target for AML treatment.
A non-rigid registration method for the analysis of local deformations in the wood cell wall
Authors: Patera Alessandra , Carl Stephan , Stampanoni Marco , Derome Dominique , Carmeliet Jan 
Published: January 2018

AbstractThis paper concerns the problem of wood cellular structure image registration. Given the large variability of wood geometry and the important changes in the cellular organization due to moisture sorption, an affine-based image registration technique is not exhaustive to describe the overall hygro-mechanical behaviour of wood at micrometre scales. Additionally, free tools currently available for non-rigid image registration are not suitable for quantifying the structural deformations of complex hierarchical materials such as wood, leading to errors due to misalignment. In this paper, we adapt an existing non-rigid registration model based on B-spline functions to our case study. The so-modified algorithm combines the concept of feature recognition within specific regions locally distributed in the material with an optimization problem. Results show that the method is able to quantify local deformations induced by moisture changes in tomographic images of wood cell wall with high accuracy. The local deformations provide new important insights in characterizing the swelling behaviour of wood at the cell wall level.
Unstable Housing and Caregiver and Child Health in Renter Families
Authors: Sandel Megan , Sheward Richard , Ettinger de Cuba Stephanie , Coleman Sharon M. , Frank Deborah A. , Chilton Mariana , Black Maureen , Heeren Timothy , Pasquariello Justin , Casey Patrick , Ochoa Eduardo , Cutts Diana 
Published: January 2018

OBJECTIVES:To evaluate how 3 forms of housing instability relate to caregiver and child health among low-income renter households.METHODS:Caregivers of children 0 to 48 months of age were interviewed in 5 urban medical centers from May 2009 to December 2015. Caregivers reported on the following: caregiver health, maternal depressive symptoms, child’s health, lifetime hospitalizations, developmental risk, and 3 housing circumstances, which were categorized as being behind on rent in the past 12 months, multiple moves (≥ 2 in past 12 months), and child’s lifetime history of homelessness. Associations with caregiver and child health outcomes were examined through multivariable logistic regression.RESULTS:Of 22 324 families, 34% had at least 1 of the following adverse housing circumstances: 27% had been behind on rent, 8% had made multiple moves, and 12% had a history of being homeless. Overlap between these was limited; 86% experienced only 1 adverse housing circumstance. Each circumstance was individually associated with increased adjusted odds of adverse health and material hardship compared with stable housing. Households behind on rent had increased adjusted odds of fair and/or poor caregiver health (adjusted odds ratio [aOR]: 1.91; 95% confidence interval [CI]: 1.77–2.05), maternal depressive symptoms (aOR: 2.71; 95% CI: 2.51–2.93), child lifetime hospitalizations (aOR: 1.19; 95% CI: 1.10–1.27), fair and/or poor child health (aOR: 1.41; 95% CI: 1.28–1.56), and household material hardships. Families with multiple moves and history of homelessness had similar adverse caregiver, child, health, and hardship outcomes.CONCLUSIONS:Three forms of housing instability were associated with adverse caregiver and child health among low-income renter households. The American Academy of Pediatrics recommends social screening within health care; providers could consider assessing for behind on rent, multiple moves, and homelessness in high-risk practices.
Az N-terminális pro-B natriureticus peptid jelentősége a felnőtt korú congenitalis szívbetegek gondozásában – Eredmények a CSONGRAD Regiszterből
Authors: Ambrus Nóra , Havasi Kálmán , Berek Krisztina , Kalapos Anita , Hartyánszky István , Bogáts Gábor , Forster Tamás , Nemes Attila 
Published: January 2018

Abstract: Introduction: The prognostic role of B-type natriuretic peptide (BNP) level was confirmed in chronic heart failure and congenital heart diseases irrespective of the aetiology. Aim: The aim of this study was to compare NT‑proBNP measured in the clinical practice and important clinical and echocardiographic parameters in patients with adult congenital heart diseases under our care. Method: Data of a total of 70 patients were analysed; 34 patients had corrected tetralogy of Fallot and 19 patients had corrected transposition of the great arteries. In 17 further cases, patients with other congenital vitiums have been involved in the study. In all cases, out-patient examination was performed with electrocardiography, echocardiography and NT-proBNP measurement. The New York Heart Association (NYHA) stages of the patients were determined and the patients filled in a questionnaire regarding their quality of life. Results: Elevated NT-proBNP level resulted in a worse quality of life (visual analogue scale, VAS) and an increased right ventricular end diastolic diameter; the incidence of arrhythmia increased as well. Negative correlation was found between the NT-proBNP level and the VAS value (r = –0.45, p = 0.0001) and the left ventricular ejection fraction (LV-EF) (r = –0.67, p = <0.0001). ROC analysis showed that NT‑proBNP≥668.1 pg/ml was the cut-off value that most accurately predicted NYHA class III–IV (sensitivity 93%, specificity 63%, area under the curve 80%, p = 0.001). Similarly, NT-proBNP≥184.7 pg/ml was found to be the cut-off value most accurately predicting LV-EF below 55% (sensitivity 66%, specificity 67%, area under the curve 77%, p = 0.02). Conclusions: NT-proBNP has a role in the evaluation of adult patients with congenital heart diseases and in determining the prognosis of these patients, and in addition to other examinations used in the follow-up of these patients, NT-proBNP may help in determining the time of reoperation or potential heart transplantation. Orv Hetil. 2018; 159(4): 141–148.
A residualis kockázat útvesztői: a maradék lipid és gyulladásos kockázat csökkentése az atherosclerosis prevenciójában
Authors: Márk László , Harangi Mariann , Paragh György 
Published: January 2018

Abstract: Since cardiovascular diseases are the main cause of mortality worldwide, the reduction of their risk is a crucial point of present-day medicine. It has been proven unequivocally that the administration of various treatments has a favorable effect on the frequency of cardiovascular events and on the atherosclerosis leading to them. Although systematic and guideline-driven administration of these drugs has led to a decrease in the incidence and mortality of vascular events, the leading position of this group of diseases in mortality and morbidity has not changed. That is why medicine, besides keeping up actual guidelines optimally, is always searching for new modalities to further decrease residual risk. This residual risk can be diverse. The present paper summarizes the possibilities of reducing residual lipid and residual inflammatory risk after treatment according to the guidelines. It has been proven that lowering LDL-cholesterol below 1.8 mmol/l has a further advantage on the occurrence of vascular events. Treating the elevated lipoprotein(a), triglyceride and low HDL-cholesterol levels should decrease the residual lipid risk. Statins and statin-ezetimibe combination, besides lipid modulation, have an anti-inflammatory effect proved by C-reactive protein level reduction. Canakinumab has solely inflammation reducing effect through the inhibition of interleukin-1β. It was administered subcutaneously once in 3 months in a large-scale clinical study and it has shown a 15% reduction in non-fatal myocardial infarction, non-fatal stroke and cardiovascular death, which opens new horizons in the anti-inflammatory treatment of atherosclerosis. Orv Hetil. 2018; 159(4): 124–130.
Zawieszenie, umorzenie oraz zrzeczenie w procesie małżeńskim w kontekście procesowej reformy papieża Franciszka z 2015 roku
Authors: Rozkrut Tomasz 
Published: January 2018

Proces kościelny, w szczególności kanoniczny proces dotyczący orzeczenia nieważności małżeństwa, najczęściej kończy się wydaniem wyroku. Dotyczy to również kanonicznego procesu małżeńskiego, czyli zwykłego procesu spornego, procesu dokumentalnego oraz nowej formy kanonicznego procesu małżeńskiego, tj. procesu małżeńskiego skróconego przed biskupem. Prawodawca kodeksowy przewiduje także inne formy zakończenia procesu kanonicznego. Do wspomnianych sposobów należą: zawieszenie instancji, tymczasowe zawieszenie instancji, umorzenie instancji oraz zrzeczenie się instancji. Szczególnym przypadkiem w procesie małżeńskim jest zawieszenie instrukcji sprawy, czyli postępowania procesowego, oraz uzupełnienie zgromadzonego materiału celem otrzymania dyspensy super rato; ponadto istnieje także możliwość przekształcenia zwykłego procesu spornego w „proces biskupi”. Należałoby również podkreślić, przede wszystkim z praktycznego punktu widzenia, że współczesny kanoniczny proces małżeński, właśnie dlatego, że ma się zakończyć stosunkowo szybko, powinien być dobrze przygotowany. W szczególności dużego praktycznego znaczenia nabiera tutaj zaproponowane przez reformę procesową papieża Franciszka badanie przedprocesowe (duszpasterskie), które powinno odbywać się w nowych strukturach parafialnych lub diecezjalnych, a stworzonych dla wiernych będących w separacji lub rozwiedzionych, podających w wątpliwość ważność ich małżeństwa lub przekonanych o jego nieważności. Powyższe nowe struktury mogłyby posłużyć także jako miejsce, w którym można by podjąć ewentualne próby pogodzenia małżonków, naturalnie o ile jest to jeszcze praktycznie możliwe. Reforma procesu małżeńskiego papieża Franciszka z roku 2015 jest na tyle dynamiczna, że należy ją odnieść również do zawieszenia, umorzenia oraz zrzeczenia instancji, które być może niecodziennie spotyka się w praktyce sądów Kościoła; winny być jednak przedstawione sytuacje prawne poprawnie stosowane w praktyce sądowej.
COMBINAÇÃO DE ESPAÇAMENTO ENTRELINHAS E DENSIDADE POPULACIONAL NO AUMENTO DA PRODUTIVIDADE EM MILHO
Authors: BOIAGO RAFAEL , GARCIA RENATO , SCHUELTER ADILSON RICKEN , BARRETO RAFAEL , DA SILVA GLACY JAQUELINE , SCHUSTER IVAN 
Published: January 2018

RESUMO - Este trabalho teve como objetivo avaliar os efeitos do arranjo espacial e da densidade de semeadura na produtividade de cinco híbridos de milho, em dois locais no cultivo de verão. Foram utilizados espaçamentos de 80 cm e de 45 cm entrelinhas, e densidades de semeadura de 42.000, 52.000, 62.000 e 85.000 plantas ha-1. As avaliações foram conduzidas em Cascavel-PR e em Rio Verde-GO. Foram observados efeitos significativos para os fatores principais (híbrido, espaçamento entrelinhas e densidade), mas não foram observadas interações entre os fatores, com exceção da interação densidade x híbrido em Rio Verde. Houve maior efeito do espaçamento entrelinhas do que da densidade populacional na produtividade de todos os híbridos. No espaçamento de 45 cm entrelinhas, os híbridos produziram, em média, 36% a mais do que no espaçamento de 80 cm, nos dois locais avaliados. Houve aumento de produtividade com aumento da densidade de semeadura até 75 mil plantas ha-1 em Cascavel, e até 85 mil plantas ha-1 em Rio Verde. Palavras-chave: Zea mays, arranjo espacial de plantas, sistemas de cultivo. COMBINING ROW SPACING AND POPULATION DENSITY IN INCREASING MAIZE YIELD ABSTRACT - This study aimed to evaluate the effects of spatial arrangement and plant density from five corn hybrids at two locations in the summer season. Row spacing used were 80 cm and 45 cm between rows and plant densities were 42,000, 52,000, 62,000 and 85,000 plants ha-1. The evaluations were conducted in Cascavel, State of Paraná, and Rio Verde, State of Goiás, Brazil. Significant effects were observed for the main effects (hybrid, row spacing and density), but there were no interactions between the main effects, with the exception of the interaction between density x hybrid in Rio Verde. There was a greater effect of row spacing than the population density on yield of all hybrids. With the row spacing at 45 cm the hybrids yielded, on average, 36% more than at a spacing of 80 cm, in the two locations. There was a trend for increased productivity with increased seeding rate up to 75,000 plants ha-1 in Cascavel, and up to 85,000 plants ha-1 in Rio Verde. Keywords: Zea mays, spatial arrangements, cultivation systems.
Apresentação
Authors: Sterzi Eduardo , Siscar Marcos 
Published: January 2018

Em 2012, o Programa de Pós-Graduação em Teoria e História Literária da Unicamp iniciou um acordo de cooperação (PROCAD-CNPq/Casadinho-CAPES) com o Programa de Literatura da Universidade Federal de Santa Catarina, tendo ainda como parceiro o Programa de Ciência da Literatura, da Universidade Federal do Rio de Janeiro. No âmbito desse convênio, configurou-se um grupo de pesquisa que vem trabalhando concentradamente com questões de poesia e que, apesar da variedade de perspectivas dos diferentes trabalhos, tem apontado para interesses comuns que provavelmente traduzem amplas demandas contemporâneas relacionadas ao poético.
Chororô, sabidão e poetaço
Authors: Marques Pedro 
Published: January 2018

Um naco de poesia e ensino. Três dentes de troça que isso é do homem, diz Rabelais. Desde que mirei a poesia, corro de chororô, sabidão e poetaço como sabiá da gaiola. “Poesia não deve dar nada”. “Ninguém lê”. “Vai de prosa”. “Máquina de sentir ou pensar”. “Vide teoria, crença”. “É Pound, é pedra, é o fim...” Queixume de plantão, frases formulares, tipo autoajuda intelectual tão longe do coletivo quão perto do totalitário.
James Hutton e o Sublime Geológico: A Teoria da Terra entre o Iluminismo e o Romantismo
Authors: Caxito Fabricio 
Published: January 2018

O trabalho do geólogo, naturalista e médico escocês James Hutton [1726-1797], no contexto do Iluminismo Escocês, sofreu grande influência das ideias de pensadores como Isaac Newton e David Hume, representando uma síntese e uma transposição para as nascentes ciências geológicas da força motriz do pensamento iluminista da época. Sua visão da terrível magnitude das forças naturais e da imensidão do tempo geológico perante a efemeridade da vida humana reflete os conceitos kantianos de Sublime Dinâmico e Matemático, respectivamente. A partir do desenvolvimento da Geologia como uma ciência que abriu os olhos humanos para a história natural, é possível traçar um paralelo entre as teorias de James Hutton e as visões sobre a natureza dos poetas românticos do século XIX, principalmente Coleridge e Wordsworth. Desta forma, a geologia nasce como ciência exatamente na encruzilhada entre dois dos maiores movimentos intelectuais e culturais da civilização ocidental, o Iluminismo e o Romantismo.