bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting the PD-1/PD-L1 pathway potentiates immunoediting and changes the dynamics of neutral evolution in a mouse model of colorectal cancer
Authors: Efremova Mirjana , Klepsch Victoria , Charoentong Pornpimol , Finotello Francesca , Rieder Dietmar , Hackl Hubert , Hermann-Kleiter Natascha , Löwer Martin , Baier Gottfried , Krogsdam Anne , Trajanoski Zlatko 
Published: January 2017

ABSTRACTThe cancer immunoediting hypothesis postulates a dual role of the immune system: protecting the host by eliminating tumor cells, and shaping the tumor by editing the genome. However, to what extent immunoediting is shaping the cancer genome is still a matter of debate. Moreover, the impact of cancer immunotherapy with checkpoint blockers on modulating immunoediting remains largely unexplored. Here we elucidated the impact of evolutionary and immune-related forces on editing the tumor in a mouse model of colorectal cancer (CRC). We first show that MC38 cell line is a valid model for hypermutated and microsatellite-unstable (MSI) CRC. Analyses of longitudinal samples of wild type and immunodeficient RAG1 knockout mice transplanted with MC38 cells revealed that upregulation of checkpoint molecules and infiltration of Tregs are the major tumor escape mechanisms. Strikingly, the impact of neutral evolution on sculpting the tumor outweighed immunoediting. Targeting the PD-1/PD-L1 pathway potentiated immunoediting and rendered tumors more homogeneous in the MC38 model. The immunoediting effects were less pronounced in a nonhypermutated/MSI- model CT26. Our study demonstrates that neutral evolution is the major force that sculpts the tumor, and that checkpoint blockade effectively enforces T cell dependent immunoselective pressure in a hypermutated/MSI model of CRC.
Shielding or engaging: the use of online shareholder platforms in investor relations
Authors: Hoffmann Christian Pieter , Aeschlimann Lea 
Published: January 2017

Purpose
The purpose of this paper is to analyze antecedents of listed corporations’ propensity to adopt online shareholder platforms. It differentiates two strategic investor relations (IR) frames, shielding and engaging, and explores their effect on ICT adoption.

Design/methodology/approach
Findings are based on a survey of 82 corporations listed on the Swiss, German and Austrian stock exchanges. The authors apply multiple linear regression analysis to test a multi-faceted adoption model.

Findings
The authors find that resource constraints, familiarity with online media and efficiency considerations drive listed corporations’ willingness to adopt online shareholder platforms. Beyond these operational antecedents, strategic considerations significantly affect adoption: IR functions geared toward shareholder engagement are more likely to apply interactive platforms, while IR departments geared toward shielding the corporation from shareholder interventions will be less attracted to the participatory affordances of online media.

Research limitations/implications
This study is limited in scope to corporations listed on the Swiss, German and Austrian stock exchanges and cannot account for antecedents distinct to other regulatory environments.

Practical implications
IR functions need to carefully develop and apply communication strategies, which in turn will inform ICT adoption. The authors find that IR departments geared toward a two-way symmetrical communication model are more attracted to the participatory affordances of online platforms. Thereby, they are more likely to innovate by employing current digital applications.

Originality/value
This study contributes to research on the benefits of digital media to two-way symmetrical and dialogic corporate communications. It is the first study to explore these relationships in the context of IR. It further contributes to research on the strategic role of IR by developing and applying two distinct strategic frames to the subject of ICT adoption in IR.
Organizational crisis communication on Facebook
Authors: Ye Lan , Ki Eyun-Jung 
Published: January 2017

PurposeThe purpose of this paper is to explore British Petroleum’s (BP) crisis response on Facebook and factors contributing to its stakeholders’ perceptions of its crisis response strategies during the Deepwater Horizon oil spill.Design/methodology/approachApplying crisis response strategies, this study content analyzed BP’s crisis communication messages and Facebook users’ comments on BP America’s Facebook page.FindingsThe results revealed that information giving strategies dominated BP’s crisis response, and Facebook users were more likely to comment favorably when BP used information giving strategies and accommodative strategies. Bolstering strategies and third-party endorsement did not achieve anticipated effectiveness.Originality/valueThe findings of this study will contribute to effective application of crisis response strategies.
Triple bottom line performance evaluation of reverse logistics
Authors: Agrawal Saurabh , Singh Rajesh Kr , Murtaza Qasim 
Published: January 2017

Purpose
The paper aims to incorporate the relationship of reverse logistics into the economic, environmental, and social sustainability, known as triple bottom line and developed a framework for reverse logistics performance evaluation.

Design/methodology/approach
The performance measures, based on triple bottom line approach, were selected, and fuzzy analytical hierarchy process and extent analysis approach was applied for estimating the weights, global weights of performance measures and hence, the reverse logistics performance index. Reverse logistics performance of three electronic companies were evaluated and compared for the demonstration of the methodology.

Findings
The results show that economic performance has highest performance index followed by environmental performance and social performance. “Recapturing value” and “return on investment” from economic, “minimum energy consumption” and “optimum use of raw material” from environmental and “community complaints” and “customer health and safety” from social perspective have higher performance indexes. Over all, “reduced packaging”, “use of recycled material” and “employee benefits” show very poor performance indexes.

Research Limitations/implications
The study will provide useful guidance to the academicians and practitioners for evaluating, improving and benchmarking the reverse logistics performance.

Originality/value
The analysis adds to the very few studies on triple bottom line aspects of reverse logistics and its performance evaluation. Also, fuzzy analytical hierarchy process and extent analysis is used first time being an efficient tool to tackle the fuzziness of the data involved in performance evaluation.
Lean management – a step towards sustainable green supply chain
Authors: BR Raghu Kumar , Agarwal Ashish , Sharma Milind Kumar 
Published: January 2017

PurposeThe purpose of this paper is to identify important factors which contribute to the evolution of Green Supply Chain (GSC) initiatives framework as a result of sustained lean strategies predominantly but not confined to aviation sector.Design/methodology/approachThis research is exploratory in nature and studies lean management implementation environment with focus on developing a framework for a GSC established through a path of identifying waste minimization techniques which automatically contribute to green initiatives in supply chain design invariably qualifying an ordinary supply chain as GSC. The approach is of identifying the framework parameters for both carbon footprint analysis and lean management. The focus of study is cross-sectional, within and outside aviation industry based on the information collected through survey methodology.FindingsThe paper identifies the key factors that are responsible to make a “green” supply chain and presents a framework to establish the same through rigorous evaluation while not losing sight of lean management requirements so that operational management perspective is not lost.Research limitations/implicationsThe target of the study is the aviation industry and its supportive upstream and downstream beneficiaries. The study has implications for managers in all types of industrial environment, especially in aviation, in the era of globalized lean supply chain establishment which helps them to convert their present lean management initiatives to GSC.Practical implicationsInputs obtained are from both literary and industrial research in a live environment and hence impacts lean management outlook and its benefits to industries.Social implicationsThis paper has vast impact on the social well being with the focus on techno – environmental green initiatives factor identification through simple implemented and available procedures with no additional cost implication.Originality/valueThis paper presents unique inputs regarding conversion of lean implementation scenario in aviation and other industries to a GSC model, with suitable incorporation of recognized factors which are outcome of complicated internal processes. It also tries to establish factors relevant for any organization in assessing lean initiatives.
RATR of adaptive angular-sector segmentation based on grey incidence analysis model
Authors: Xiao Yongsheng , Huang Lizhen , Zhou Jianjiang 
Published: January 2017

Purpose
The purpose of this paper is to solve the azimuth sensitivity of a high-resolution range profile (HRRP), which is one of the biggest obstacles faced by a radar automatic target recognition (RATR) system.

Design/methodology/approach
Aimed at addressing the shortcomings of the equal angular-sector segmentation based on the scatterer model, an adaptive angular-sector segmentation is proposed on the basis of grey incidence analysis (GIA).

Findings
The main conclusions reached are as follows. First, the adaptive angular-sector segmentation in terms of GIA is suitable for RATR based on the HRRP; and, second, the adaptive angular-sector segmentation based on the type-B degree of grey incidence model is better than the Deng-Si degree of grey incidence model and the degree of grey slope incidence model.

Practical implications
The outcome obtained in this paper can be selected for the RATR application.

Originality/value
This paper has been built on the basis of previous research achievements, and a new RATR method of adaptive angular-sector segmentation is presented based on the GIA.
Implicit managerial theories about followers and customers
Authors: Hommelhoff Sabine 
Published: January 2017

PurposeThe purpose of this paper is to take a new look at an old idea: since McGregor’s work in the 1960s, it is common knowledge that managers’ implicit theories about their followers can have self-fulfilling consequences. Surprisingly, McGregor’s work has largely remained within the bounds of employee motivation and has not met with a wide response in related fields such as service management. Assuming that managers do not only hold implicit theories of their followers but also of their customers (i.e. implicit customer theories), this paper transfers McGregor’s Theory X and Theory Y to the service context. It further derives a framework of possible consistencies and inconsistencies between management styles and service strategies, depending on implicit managerial theories about the average employee and customer.Design/methodology/approachThis conceptual paper integrates a management classic, current empirical findings, and media reports into a new line of thought.FindingsThis paper develops and undergirds the thesis that it is conducive to the development of trustful and productive relationships both with customers and followers if managers proceed from confident assumptions about them, thereby activating virtuous circles instead of vicious cycles.Originality/valueThis paper links concepts from the organizational domain to the service domain. It implies a normative component in arguing for the productive potential of positive and the destructive potential of negative assumptions about both followers and customers. The value of this idea lies in the potential for positive relational dynamics and better customer and workplace relationships.
Observing delightful experiences of other customers: the double-edged sword of jealousy and joy
Authors: Ludwig Nadine L. , Barnes Donald C. , Gouthier Matthias 
Published: January 2017

Purpose
Deciding on the appropriate level of service is one of the paramount decisions a firm must make. Making this decision more complicated is the debate regarding the viability of aiming for the highest level of service or customer delight. One avenue of research missing from the literature is the impact of providing delight to one customer while in the presence of others. In response the purpose of this paper is to evaluate the emotional and cognitive reactions of the observing customer.

Design/methodology/approach
Structural equation modeling was utilized to evaluate a sample of 272 respondents. Additional moderation analysis was conducted on the impact of perceived deservingness.

Findings
Findings indicate that the observing customer experiences the dual effects of joy and jealousy which both impact perceptions of unfairness and subsequent behaviors of complaining and repurchase. The perceived deservingness of the customer experiencing the delight is shown to reduce the impact of jealousy on unfairness.

Research limitations/implications
The main limitations include cross-sectional data and the fact that the data were retrospective.

Practical implications
This research suggests that firms should embrace the positive contagion that occurs between the delighted customer and observer while attempting to minimize the impact of jealousy.

Originality/value
This is the first research to quantitatively evaluate the impact of a customer viewing another customer receiving delight.
Birth of puppies of predetermined sex after artificial insemination with a low number of sex‐sorted, frozen–thawed spermatozoa in field conditions
Authors: Wei Yun‐Fang , Chen Fang‐Liang , Tang Shu‐Sheng , Mao Ai‐Guo , Li Li‐Guang , Cheng Lu‐Guang , Chen Chao , Li Fei‐Xiang , Wang Bin , Xu Tao , Zhang Yue‐Jun , Li Jing , Wan Jiu‐Sheng 
Published: January 2017

AbstractThe aim of this study was to evaluate fertility and sex ratios after artificial insemination in dogs under field conditions. Semen was cryopreserved as unsorted (control) or was separated into X‐ and Y‐chromosome‐bearing sperm using a cell sorter. Sixty female dogs were inseminated with frozen–thawed spermatozoa of 100 × 106 unsorted (a dose in practice) and 4 × 106 sorted (X and Y group, respectively). A total of 20 dogs became pregnant and 126 puppies were born from the three groups. The percentage of parturition was similar for the X (5/20; 25.0%) and Y (4/20; 20.0%) group (P > 0.05), but lower than controls (11/20; 55.0%) (P < 0.05). Ultimately 28 out of the 32 puppies produced from X group were female (87.5%) and 19/22 (86.4%) puppies of Y group were male. In contrast, sex ratio (51.4% to 48.6%) in the control was significantly different from the X, Y group (P < 0.05). However, male and female puppies in the control had similar birth weights and weaning weights to those from the X and Y groups. This preliminary information indicated that normal puppies of predicted sex can be produced with low numbers of sorted cryopreserved dog spermatozoa at a farm level, making sperm‐sexing technology potentially applicable for elite breeding units.
Anti‐N‐methyl‐D‐aspartate receptor encephalitis: An atypical presentation with ataxia
Authors: Barquero‐Madrigal Alejandro 
Published: January 2017

AbstractBackgroundAnti‐N‐methyl‐D‐aspartate receptor encephalitis is a disorder characterized by psychiatric symptoms, cognitive impairment, movement disorders and autonomic dysfunction; originally thought to be a paraneoplastic syndrome. The classical clinical picture comprises five stages, but there are some milder or incomplete forms of the disorder.Case presentationA 57‐year‐old man, with no previous psychiatric or comorbid illnesses, presented a clinical picture of initial psychosis followed by ataxia and headache. Serum and cerebrospinal fluid determination of anti‐N‐methyl‐D‐aspartate receptor antibodies confirmed the diagnosis of autoimmune encephalitis.ConclusionsClinicians should be aware of some psychiatric manifestations that do not necessarily correspond to psychiatric illness. Anti‐N‐methyl‐D‐aspartate encephalitis is a good example, and atypical presentations of the disorder are particularly challenging.
Fish trait diversity in littorals of two floodplain lakes of the highly biodiverse Caura River, Venezuela
Authors: Echevarría Gabriela , González Nirson 
Published: January 2017

AbstractWe studied the trait diversity and structure in the fish communities of two floodplain lakes of the Caura River: Aricagua and Paramuto, during one hydrological cycle. We calculated taxonomic and a functional alpha and beta diversities and made comparisons among hydrological seasons and among habitats within each lake based on rarefactions. The trait structure was explored with an RLQ (analysis of a table R of environmental conditions, a table L of abundances of species and a table Q of species traits) analysis, and pairwise relationships between environmental variables and traits were explored with fourth‐corner analyses. Despite its smaller extension, Paramuto showed higher alpha taxonomic and trait diversities. The substrates of open sand and those covered by leaf litter were the most diverse habitats in terms of both species and traits. The trait structure of the fish communities was influenced by the hydrological seasons, the lakes as well as water pH and temperature, and in a lesser degree dissolved oxygen, habitat type and total dissolved solids in the water. These factors constitute the habitat templet for the fish community's composition and trait structure.
Little chance for divergence: The role of interlocutor language constraint in online bilingual accommodation
Authors: Vincze László , Gasiorek Jessica , Dragojevic Marko 
Published: January 2017

Drawing on communication accommodation theory, the present paper explored how affective (i.e. identity related) and cognitive (i.e. comprehension related) motives drive young Swedish‐speaking Finns to use Swedish in online communication when interacting with Finnish speakers. Questionnaire data were collected among Swedish‐speaking secondary school students (N = 124). A Bayesian moderated mediation revealed that the use of Swedish was guided both by cognitive and affective motives. Furthermore, affective motives were stronger predictors of language behaviour in cases where participants did not perceive they were restricted by interlocutors' competence in Swedish. However, a similar effect was not detected for cognitive motives. Findings and their theoretical implications are discussed with respect to bilingual accommodation.
Live donor liver transplantation for a child presented with severe hepatopulmonary syndrome and nodular liver lesions due to Abernethy malformation
Authors: Yilmaz Cahit , Onen Zafer , Farajov Rasim , Duygu Onur S. , Doganay Latife , Yuksel Alper , Alper Mehmet , Zeytunlu Murat , Arikan Cigdem , Kilic Murat 
Published: January 2017

AbstractA 15‐year‐old boy first presented with severe lung lesions and hypoxia and he was considered as a lung transplant candidate. Upon evaluation, hepatopulmonary syndrome, multiple nodular liver lesions, and Abernethy type 1b malformation were diagnosed. The patient underwent successful right lobe live donor liver transplantation, and all of the symptoms disappeared soon after the transplant. He is currently alive and well with excellent liver and lung functions 4 years after surgery.
Effects of stem cell transplantation on bone mineral density and vitamin D status in children with thalassemia major
Authors: Gürlek Gökçebay Dilek , Ozbek Namik , Yazal Erdem Arzu , Culha Vildan , Yarali Nese , Isik Pamir , Avci Zekai , Azik Fatih , Demirel Fatma , Tunc Bahattin 
Published: January 2017

AbstractHSCT is a curative treatment in TM, but conditioning and immunosuppressive treatment may affect bone metabolism. In this retrospective study, we aimed to compare BMD, vitamin D status, and growth in children with TM who underwent HSCT to those in children with TD TM. Twenty‐three children with TM who underwent HSCT (mean age 7.1 years [1.03‐14.7]) and 24 children with TD thalassemia (mean age 9.8 years [1.6‐14]) were recruited. Lumbar spine BMD of TD thalassemia patients was higher than those in patients who had HSCT at both baseline and second‐year assessments (P=.009, P<.001, respectively). However, BMD Z scores or serum 25‐OH vitamin D levels were not different in two groups. Being >10 years of age was a significant risk factor for low BMD, height, and weight Z score for both groups. Patients who underwent HSCT with Pesaro risk class II or III had higher risk for low BMD compared to those risk class I patients (P=.044). In conclusion, children with TM who were >10 years at HSCT are at risk for low BMD and growth retardation. HSCT had no effect on BMD deficit in children with TM.
Post‐storm sediment burial and herbivory of Vallisneria americana in the Hudson River estuary: mechanisms of loss and implications for restoration
Authors: Hamberg Jonas , Findlay Stuart E. G. , Limburg Karin E. , Diemont Stewart A. W. 
Published: January 2017

AbstractThis article investigates the mechanics of loss of Hudson River Vallisneria americana after the high volume storms at the end of the 2011 growing season, when two severe weather events—Tropical Storm Irene and the remnants of Tropical Storm Lee—struck the Hudson River watershed. In 2012, the distribution of the most common species of submerged aquatic vegetation (SAV), Vallisneria americana (wild celery, water celery, or tape grass), in the Hudson River estuary declined by more than 90%, with no appreciable recovery in 2013 and 2014. Because of its important habitat value for aquatic life and for increasing dissolved oxygen, managers and scientists have begun discussing the reasons for the loss, as well as how to assist its recovery through assisted restoration efforts in the estuary. Supported by in situ and in vitro experiments, the article posits the hypothesis that sediment, washed into the river by the storm, buried overwintering tubers of the plant, thus reducing sprouting success. Sprouting was as low as 50% with sediment depth between 2 and 5 cm; sprouting did not occur with sediment depth greater than 10 cm. Field experiments found no support for the hypothesis that herbivory inhibited regrowth of the plant after the storm events. These results suggest that future assisted restoration of Vallisneria americana and SAV in general may require attention to system‐specific factors.