bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEW FACTS FOR OKSANA DRAI-KHMARA ASHER’S BIOGRAPHY
Authors: Vusatiuk Nataliia 
Published: October 2024

The paper reconstructs the biography of Oksana Drai-Khmara Asher, the daughter of Mykhailo Drai-Khmara and a literary critic, poet, translator, and pianist. The research is based on documents recently transferred to the Department of Manuscripts and Textual Studies of Taras Shevchenko Institute of Literature of the National Academy of Sciences of Ukraine, as well as the memoirs of her contemporaries. Oksana Drai-Khmara’s documents provide different dates and places of her birth. According to the archival sources, the researcher established that the actual date of birth was March 20, 1923.
From July 1937 to the summer of 1938, Oksana Drai-Khmara, along with her mother, was exiled to Belebei, Bashkiria. In October 1942, she moved to Prague, where she studied at the Higher School of the Institute of Music. The German period of her life lasted from June 1945 to September 1946 when Oksana Drai-Khmara changed several places of residence (Lichtenhaag, Munich, and Hanover). After moving to Belgium, she studied at the Royal Conservatory of Brussels. Emigration to the United States of America took place on May 23, 1951. From 1952 to 1956, Oksana studied at the Slavic Department of Columbia University, where she obtained her master’s degree. In 1964–1967, Asher studied at the Sorbonne University in Paris, where she defended her PhD thesis. On her return to America, Drai-Khmara taught Russian language and literature at Long Island University and the Polytechnic Institute of New York and was actively involved in the Ukrainian diaspora’s life in the USA.
In addition to documenting Oksana Drai-Khmara’s educational and career path, the author of the paper revealed unknown details of her first marriage to the historian Ihor Shevchenko and provided information about her second spouse Peter Asher.
Mortality rate of percutaneous coronary interventions in ST-segment elevation myocardial infarction patients under the public health insurance schemes of Thailand
Authors: Chumsantivut Suppavit , Lertmaharit Somrat , Rattananupong Thanapoom , Lertsuwunseri Vorarit , Athisakul Siriporn , Wanlapakorn Chaisiri , Srimahachota Suphot 
Published: October 2024

BackgroundIn Thailand, access to specific pharmaceuticals and medical devices for ST-elevation myocardial infarction (STEMI) patients is restricted within certain healthcare systems, leading to inequalities in the quality of medical care among different healthcare systems. This study aims to compare mortality rates within one year of STEMI patients among the public health insurance schemes of Thailand.MethodologyThis study is a single-center retrospective analysis of patients with STEMI treated with primary percutaneous coronary intervention (pPCI). It involves patients utilizing various state health insurance schemes in Thailand from January 1, 2010, to December 31, 2020. Data collection occurred through the hospital's computerized management system and the registration administration office of the Department of Provincial Administration.ResultsThe study involved 1,077 patients, categorized into three groups based on their state health insurance: Universal Health Coverage (UC) (546 patients, 50.7%), Social Security System (SS) (199 patients, 18.5%), and Civil Service Reimbursement (CS) (332 patients, 30.8%). The one-year mortality rates in these groups were 10.57%, 4.21%, and 6.47%, respectively (p = 0.010). In the unadjusted model, the SS group showed a lower risk of one-year mortality [Hazard Ratio (HR) 0.38, 95% CI 0.18–0.80, p = 0.011], and the CS group also demonstrated a lower risk (HR 0.59, 95% CI 0.35–0.99, p = 0.047) compared to the UC group. In the adjusted model, only the CS group significantly reduced the risk of one-year mortality. Other factors that affected one-year mortality were age ≥65 years, prior coronary artery diseases, Killip class 3–4, pre-discharge prescription of angiotensin-converting enzyme inhibitors, occlusion in the left anterior descending artery, multivessel disease, in-hospital atrial fibrillation/flutter and in-hospital pericardial effusion.ConclusionHealthcare schemes play a significant role in influencing one-year mortality rates among STEMI patients treated with pPCI. This information would be crucial for developing strategies and programs to aid healthcare policymakers at both regional and international levels in reducing morbidity and mortality.
Structural colouration in Drosophila wings is thermally plastic and exhibits ecological variation
Authors: Garg Divita , Dhotre Kanak , Mayekar Harshad Vijay , Singh Grewal Raghwinder , Rajpurohit Subhash 
Published: October 2024

IntroductionStructural colour patterns and their functions in insect wings are less known. Wing interference patterns (WIPs) are colour patterns apparent when wings are viewed against black backgrounds; the angle of incident light and wing surface structures also influence the resulting wing colour pattern. To date, WIPs are correlated with mate attraction, while the impact of geography and environment on WIPs remains unexplored. We explore WIP variation in Drosophila melanogaster populations collected from three altitudes and also compare WIP variation in sibling species D. melanogaster and D. simulans reared at three different temperatures to understand if local selection pressures could also influence WIPs.MethodologyWings of D. melanogaster males were collected from three different altitudes, and D. melanogaster and D. simulans males reared at three different temperatures were imaged. Images were analysed for their relative red, green and blue content in the RGB colour space. In representative images, wing thickness was assessed using the Newton colour series.ResultsAn altitudinal cline in WIPs was observed in the cosmopolitan D. melanogaster collected from the Western Himalayas. Relative RGB values and increase in altitudes were negatively correlated. Thermal responses in WIPs were parallel for both D. melanogaster and D. simulans. Relative RGB values were negatively correlated with rearing temperature. In both species, wing thickness measurements indicated that the wings of flies reared at low temperatures had greater blueness (cyan and magenta) compared to flies reared at moderate to high temperatures; the latter had more green and yellow content. Wing thickness pattern was also consistent for D. melanogaster flies collected from low versus higher altitudes.DiscussionWe find WIPs to be a plastic trait in response to temperature. WIP response to thermal variation corroborates with the temperature of the geographic origin in D. melanogaster. The adaptive significance of WIP variation and associated wing thickness remains unclear. Future studies could explore the underlying adaptive significance of structural colour patterning under different environmental conditions.
Hemopexin alleviates sterile inflammation in ischemia-reperfusion-induced lung injury
Authors: Nakagiri Tomoyuki , Köhler Nadine R. , Janciauskiene Sabina , Neubert Lavinia , Knöfel Ann-Kathrin , Pradhan Pooja , Ruhparwar Arjang , Ius Fabio , Immenschuh Stephan 
Published: October 2024

IntroductionPulmonary ischemia-reperfusion (IR) injury (IRI) plays a significant role in various lung disorders and is a key factor in the development of primary graft dysfunction following lung transplantation. Hemopexin (Hx) is the major serum scavenger protein for heme, which is a prooxidant and pro-inflammatory compound. In the current study, we hypothesized that Hx could confer beneficial effects in sterile inflammation induced by IR-mediated lung injury.MethodsTo examine this hypothesis, we administered Hx in an experimental mouse model of unilateral lung IRI.ResultsOur results demonstrate that treatment with Hx alleviated histopathological signs of inflammation in ischemic lungs, as evidenced by a reduction in the number of infiltrating neutrophils and decreased levels of perivascular edema. In addition, thrombotic vaso-occlusion in pulmonary blood vessels of IRI lungs was reduced by Hx. Immunohistochemical analysis revealed that Hx inhibited the up-regulation of heme oxygenase-1, an enzyme highly induced by heme, in ischemic lungs. Finally, Hx administration caused a decrease in the levels of circulating B- and CD8+ T-lymphocytes in the peripheral blood of mice with pulmonary IRI.ConclusionThese findings suggest that the serum heme scavenger protein Hx holds therapeutic promise in alleviating lung IRI-mediated sterile inflammation. Thus, Hx may represent a preemptive therapeutic approach in IR-related lung disorders such as primary graft dysfunction in lung transplantation.
Validity of a four-item questionnaire in French assessing attachment to meat
Authors: Sebo Paul , Tudrej Benoit , Bernard Augustin , Delaunay Bruno , Dupuy Alexandra , Malavergne Claire , Maisonneuve Hubert 
Published: October 2024

BackgroundThe 16-item Meat Attachment Questionnaire (MAQ-16) assesses emotional and cognitive attachment to meat across four dimensions: hedonism, affinity, entitlement, and dependence. Recently validated in French, we aimed to develop and validate a shorter, four-item version (MAQf-4) to reduce participant burden.MethodsIn this 2023 observational study in the Rhône-Alpes region, 919 primary care patients were invited to complete the French MAQ-16 (MAQf-16). Classical test theory guided the development of the MAQf-4, and Spearman’s correlation coefficients assessed its correlation with the MAQf-16 (dimension and overall scores). We also evaluated the diagnostic performance of the MAQf-4 for identifying patients with high meat attachment (MAQf-16 score &gt; 60).ResultsA total of 822 patients participated (65.3% women; median age = 52; participation rate = 89.5%). The MAQf-4 showed strong correlations with the MAQf-16 (rho = 0.83 for hedonism, 0.77 for affinity, 0.70 for entitlement, 0.79 for dependence, and 0.86 for the overall score, all p-values &lt;0.001). A score &lt; 15 on the MAQf-4 (sensitivity = 91%, NPV = 96%) effectively excluded patients with low meat attachment, while a score ≥ 17 (specificity = 96%, PPV = 84%) accurately identified those with high attachment.ConclusionThe MAQf-4 demonstrated strong correlation with the MAQf-16 and accurately identified high attachment to meat. It may serve as a useful tool in research and clinical settings, though further validation is required before broad implementation in French primary care.
PanicRoom: a virtual reality-based Pavlovian fear conditioning paradigm
Authors: Lucifora Chiara , Gangemi Aldo , D’Italia Giovanni , Culicetto Laura , Ferraioli Francesca , Grasso Giorgio Mario , Vicario Carmelo Mario 
Published: October 2024

IntroductionPavlovian fear conditioning is an experimental paradigm used to study the acquisition and extinction of fear responses and the various aspects of fear and anxiety. We developed a virtual reality (VR) version of this paradigm to leverage the benefits of virtual reality, such as ecological validity, standardization, safety, and therapeutic applications. Our objective was to create an open-source and immersive environment for studying fear-related responses using Unity Engine 3D and the Oculus Rift device.MethodsIn this virtual environment, the participants encountered a monster screaming at 100 dB approaching them as the fear-inducing stimulus (unconditioned stimulus or US). Our protocol included three sessions: habituation, acquisition, and extinction, with two stimuli associated with different doors (blue vs. red). The blue door (CS+) was linked to the US, while the red door (CS−) was the control. We tested this VR paradigm on 84 young participants, recording their skin conductance response (SCRs) and fear stimulus ratings (FSRs) on a 10-point Likert scale.ResultsThe findings showed significantly higher SCRs and FSRs for CS+ as compared to CS− during the acquisition phase and higher SCRs and FSRs for CS+ during the acquisition phase as compared to the habituation and extinction sessions.Discussion and conclusionsThese results supported the reliability of the protocol for studying fear and anxiety-related conditions.
Generative artificial intelligence model for simulating structural brain changes in schizophrenia
Authors: Yamaguchi Hiroyuki , Sugihara Genichi , Shimizu Masaaki , Yamashita Yuichi 
Published: October 2024

BackgroundRecent advancements in generative artificial intelligence (AI) for image generation have presented significant opportunities for medical imaging, offering a promising way to generate realistic virtual medical images while ensuring patient privacy. The generation of a large number of virtual medical images through AI has the potential to augment training datasets for discriminative AI models, particularly in fields with limited data availability, such as neuroimaging. Current studies on generative AI in neuroimaging have mainly focused on disease discrimination; however, its potential for simulating complex phenomena in psychiatric disorders remains unknown. In this study, as examples of a simulation, we aimed to present a novel generative AI model that transforms magnetic resonance imaging (MRI) images of healthy individuals into images that resemble those of patients with schizophrenia (SZ) and explore its application.MethodsWe used anonymized public datasets from the Center for Biomedical Research Excellence (SZ, 71 patients; healthy subjects [HSs], 71 patients) and the Autism Brain Imaging Data Exchange (autism spectrum disorder [ASD], 79 subjects; HSs, 105 subjects). We developed a model to transform MRI images of HSs into MRI images of SZ using cycle generative adversarial networks. The efficacy of the transformation was evaluated using voxel-based morphometry to assess the differences in brain region volumes and the accuracy of age prediction pre- and post-transformation. In addition, the model was examined for its applicability in simulating disease comorbidities and disease progression.ResultsThe model successfully transformed HS images into SZ images and identified brain volume changes consistent with existing case-control studies. We also applied this model to ASD MRI images, where simulations comparing SZ with and without ASD backgrounds highlighted the differences in brain structures due to comorbidities. Furthermore, simulating disease progression while preserving individual characteristics showcased the model’s ability to reflect realistic disease trajectories.DiscussionThe results suggest that our generative AI model can capture subtle changes in brain structures associated with SZ, providing a novel tool for visualizing brain changes in different diseases. The potential of this model extends beyond clinical diagnosis to advances in the simulation of disease mechanisms, which may ultimately contribute to the refinement of therapeutic strategies.
Passiflora incarnata L., herba, in benzodiazepine tapering: long-term safety and efficacy in a real-world setting
Authors: Carminati Matteo , Tondello Mattia , Zanardi Raffaella 
Published: October 2024

IntroductionChronic and inappropriate benzodiazepine (BDZ) prescription and intake represent an important health and social concern worldwide. The aim of our study was to investigate the safety and efficacy of P. incarnata L., herba in reducing BDZ misuse in a real-world population of depressed and anxious patients in a long-term treatment with BDZs.MethodsOver an 18-month period (from July 2021 to December 2022), we previously conducted a retrospective and naturalistic study on euthymic outpatients with a diagnosis of anxiety or depression and chronically taking BDZs. In this study we contacted patients 12 months after their enrollment in the previous study to assess their disease status and their BDZs and P. incarnata intake.ResultsOur findings support the effectiveness of a dry extract of P. incarnata L., herba, as an add-on treatment during BDZ tapering in patients with anxiety or depression. We confirmed this effect to be sustained over time, and P. incarnata showed to be easily discontinued with no rebound, withdrawal or psychological dependence effect. The absence of side effects and adverse events confirmed the safety of P. incarnata in a real-world population. Personality disorders confirmed to be a relevant risk factor for maintaining addictive behavior, even when symptoms associated to withdrawal seem to be not particularly relevant.DiscussionWe confirmed the possible effectiveness of P. incarnata as an add-on treatment in BDZ reduction. Further studies may be helpful to better investigate the promising properties of P. incarnata in the management of relevant clinical issues, such as anxiety disorders and addiction, that are classically known to benefit from GABAergic treatments.
Musculoskeletal disorders among teachers: a systematic review and meta-analysis
Authors: Tahernejad Somayeh , Hejazi Anahita , Rezaei Ehsan , Makki Faezeh , Sahebi Ali , Zangiabadi Zahra 
Published: October 2024

IntroductionAs a result of the demands of their profession, teachers encounter a range of ergonomic risk factors and are highly susceptible to developing musculoskeletal disorders (MSDs). Accordingly, this systematic review and meta-analysis was carried out to examine the frequency of MSDs among teachers.Materials and methodsThe present research followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines and its protocol was registered in international prospective register of systematic review (PROSPERO) under the code CRD42024509263. To conduct the searches, various databases such as PubMed, Scopus, Web of Science, Science Direct, SID, ISC, and Google Scholar were utilized, and the search period was until February 7th, 2024 without time restriction. A random effects model was employed for meta-analysis, and I2 index was utilized to assess heterogeneity among the studies. Data analysis was carried out using STATA (version 14).ResultsAfter an initial search across the mentioned databases, a total of 2,047 articles were identified. Following screening, study selection, and quality evaluation, 44 studies were ultimately chosen for meta-analysis, involving 15,972 teachers. The results of the meta-analysis revealed that the overall prevalence of MSDs among teachers is 68% (95% CI: 61–75, I2 = 99.2%, p &lt; 0.001). Furthermore, the prevalence rates of MSDs in different body regions, such as the neck (47%), lower back (47%), shoulder (44%), upper back (37%), knee (35%), ankle (30%), wrist (27%), hip (22%), and elbow (13%), were reported.ConclusionThe overall prevalence of MSDs among teachers is relatively high. Neck and lower back pain are more common among them compared to other body regions. It is recommended that periodic occupational medicine examinations, training, and the implementation of ergonomic interventions for this occupational group focus on assessing the risk factors for MSDs, especially in the neck and lower back regions.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=509263, identifier CRD42024509263.
Perceptions of primary healthcare providers for screening and management of mental health disorders in India: a qualitative study
Authors: Sangwan Ramesh Kumar , Kansara Darshana , Matoria Santosh , Ali Haider , Khetan Mukti , Singh Vishal , Thakor Mahendra , Huda Ramesh Kumar , Babu Bontha V. 
Published: October 2024

IntroductionIndividuals experiencing mental health disorders encounter numerous challenges while accessing mental healthcare services. Despite the inclusion of mental health in the primary healthcare system, screening and managing mental health disorders remain significantly overlooked. Therefore, there is a need to understand the perceptions of healthcare providers in primary care settings, identify the challenges faced, and gather suggestions for effective mental healthcare delivery.MethodsThe present qualitative study was conducted in 13 primary healthcare facilities in the Jodhpur district of Rajasthan, India, from 2023 to 2024 among 25 primary healthcare providers. Semi-structured interview guides were developed for each category of primary healthcare provider, including Medical Officers, Community Health Officers, and General Nurse Midwives, Auxiliary Nurse Midwives and in-depth interviews were recorded, transcribed, and thematically analyzed using codes and sub-codes.ResultsResults are summarized under the themes: (i) Navigating Mental Healthcare in Primary Healthcare Facilities, (ii) Challenges and Barriers in Mental Healthcare Delivery, (iii) Recommendation for Enhancing Mental Healthcare Services, and (iv) Approaches for Comprehensive Capacity Building Training and Module and further findings of each theme are presented under various sub-themes.ConclusionThe findings suggest that despite a perceived competence in providing mental health services, there were substantial levels of negative attitudes towards mental health disorders among participants and provide insights for policymakers and healthcare professionals to develop targeted interventions and improve mental healthcare delivery at primary care facilities.
The influence of physical literacy of student with different obesity levels on physical fitness: the mediating effect of MVPA
Authors: Yan Wenjing , Nie Mingjian , Ma Ruisi , Guo Qi , Li Hongjuan 
Published: October 2024

BackgroundPerceived physical literacy (PL) is a potential factor for improving health and physical activity, but the relationship between PL and physical fitness (PF) among college students with different obesity levels has not yet been determined.PurposeThe aim of this study was to explore the correlation between PL, moderate-to-vigorous physical activity (MVPA), and PF among college students with different obesity levels.MethodsWe recruited Chinese university students to complete a questionnaire and conducted a survey using the Perceived Physical Literacy Instrument Scale (PPLI-SC) and the International Physical Activity Questionnaire Short Form (IPAQ-SF). The physical fitness test data were used for data analysis. The direct and indirect impacts were analyzed using Pearson correlation and the SPSS Hayes process macro (Model 4).ResultsThe study surveyed 909 boys and 1,668 girls for a total of 2,577 valid questionnaires. Similarly, the MVPA and perceived PL of boys were significantly greater than those of girls (p &lt; 0.01), but the opposite was true for the PF score. The correlation analysis showed that MVPA, perceived PL, and PF were significantly correlated (p &lt; 0.01). For normal weight student, the results showed that the direct effect of PL on PF was still statistically significant (β = 0.076, p &lt; 0.01) after adding MVPA; MVPA had a positive effect on PF after controlling for perceived PL (β = 0.055, p &lt; 0.05). Perceived PL has a positive effect on MVPA (β = 0.123, p &lt; 0.01). The mediating effect of MVPA was notably significant, with a mediation effect percentage of 7.9%. However, it has been found that among the underweight population, there is an absence of a significant relationship between PL, PF, and MVPA (p &gt; 0.05). Contrarily, in the overweight and obese groups, the mediating role of MVPA in the relationship between PL and PF was not statistically supported (−0.002, 0.033).ConclusionFor normal weight student, perceived PL has a positive impact on PF and can also be promoted by increasing the pathway of MVPA. For both underweight individuals and obese populations, further investigation is needed into methods for promoting PA and improving PF.