bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Pharmacology Analysis Reveals Multi-target Interactions of Phytochemicals in Cardiospermum halicacabum and their Potential in
Breast Cancer Therapy
Authors: Shanmugarajan Dhivya , David Charles , Parihar Arpana , Kulkarni Pallavi , Arya Neha , Khan Raju 
Published: September 2024

Aims:
This present study aims to probe the interrelationships between phytochemical
components and drug targets in Cardiospermum halicacabum.

Background:
Indian traditional medicine, often called Ayurveda, has a rich history of using medicinal
plants for various health remedies and treatments. Network pharmacology plays a significant
role in understanding the complex interactions between bioactive compounds in herbal medicinal
plants and the human body.

Objective:
Medicinal plants are abundant in bioactive compounds, each possessing unique biological
activities. However, certain unexplored biological activities of medicinal plants remain underrepresented
in therapeutic studies. This study seeks to explore the connections between phytochemical
components and drug targets specifically within Cardiospermum halicacabum.

Methods:
Metabolites were associated with various targets, and network analysis was conducted
to assess the gene-metabolite network using cytoHubba. Genes were clustered to understand their
involvement in gene ontology, biological processes, and metabolic pathways. K-means clustering
illustrated a network of genes related to breast cancer pathways. Molecular docking analysis was
performed for common genes within multiple targets to assess docking scores and interactions.

result:
Network analysis revealed six key metabolites closely interacting with multiple targets. Antioxidant activity was assessed using the DPPH assay, demonstrating significant effects (inhibition 74.08 ± 0.67%). Cytotoxicity against MCF-7 and MDA-MBA 231 cell lines showed IC50 values of 110.7 µg/mL and 141.2 µg/ml, respectively, indicating potential cytotoxic effects.

Results:
Network analysis revealed six key metabolites closely interacting with multiple targets.
Antioxidant activity was assessed using the DPPH assay, demonstrating significant effects (inhibition
74.08 ± 0.67%). Cytotoxicity against MCF-7 and MDA-MBA 231 cell lines showed IC50
values of 110.7 μg/mL and 141.2 μg/ml, respectively, indicating potential cytotoxic effects.

Conclusion:
This study highlights the importance of plant metabolites and their interactions with
multiple targets through network pharmacology analysis. It suggests the synergistic potential of
compounds with multiple targets, providing insights into their therapeutic value, particularly in
breast cancer therapy.
MBPathNCP: A Metabolic Pathway Prediction Model for Chemicals and Enzymes Based on Network Consistency Projection
Authors: Chen Lei , Hu Huiru 
Published: September 2024

Background:
Metabolic pathway is an important biological pathway in living organisms
as it produces necessary energy to maintain vital movement. Although main part of metabolic
pathway has been uncovered by the great efforts in recent years, its completeness is still a problem.
The undetected chemical reactions in metabolic pathway have become a hinder for better understanding
on its mechanism. Prediction of metabolic pathways that a chemical or enzyme can participate
in is the first step to remove this hinder.

Objective:
This study aimed to design an effective computational method to predict the metabolic
pathways of chemicals and enzymes.

Methods:
A new computational model was proposed to predict the metabolic pathways of chemicals
and enzymes, which was called MBPathNCP. The kernels for chemicals/enzymes and pathways
were constructed using the interactions of chemicals and proteins, and the validated associations
between chemicals/enzymes and pathways. The network consistency projection was applied to
the kernels and association adjacency matrix to yield the association score for each pair of chemicals/
enzymes and pathways.

Results:
Cross-validation results on this model shown its good performance. The further tests indicated
the reasonability of the entire architecture and its superiority when the negative samples were
much than positive samples.

Conclusion:
The proposed model MBPathNCP was efficient to predict the metabolic pathways of
chemicals and enzymes and can be a latent useful tool to investigate metabolic pathway system.
Targeting Daily Positive Events to Improve Emotional and Functional Well-Being in Adults With Fibromyalgia: Insights From the LARKSPUR Randomized Controlled Trial
Authors: Ong Anthony , Wilcox Kenneth , Reid M Carrington , Wethington Elaine , Cintron Dakota , Addington Elizabeth , Goktas Selin , Moskowitz Judith 
Published: September 2024

Background
Fibromyalgia is a chronic pain condition characterized by widespread musculoskeletal pain, fatigue, and cognitive difficulties, affecting individuals across all age groups. Positive affect (PA) interventions have shown promise in enhancing emotional well-being and pain management in patients with diverse chronic pain conditions. However, the efficacy of internet-delivered PA interventions for individuals with fibromyalgia remains understudied.

Objective
This randomized controlled trial investigated the efficacy of a web-based PA regulation intervention—Lessons in Affect Regulation to Keep Stress and Pain Under Control (LARKSPUR)—in enhancing emotional and functional well-being among adults with fibromyalgia syndrome.

Methods
A total of 95 participants with fibromyalgia syndrome aged 50 years and older (89/95, 94% female) were randomized to one of two fully automated conditions: (1) LARKSPUR (n=49) or (2) emotion reporting/attention control (n=46). At the postintervention and 1-month follow-up time points, participants completed 7 consecutive, end-of-day, web-based reports capturing positive events (PE), pain, fatigue, PA, and negative affect.

Results
Compared to control, LARKSPUR resulted in greater improvements in daily affective responsivity to PE at the postintervention time point, including greater reductions in negative affect (bL–bC=–0.06, 95% highest posterior density interval [HPD] –0.10 to –0.02) and increases in PA (bL–bC=0.10, 95% HPD 0.02-0.19). Furthermore, across the postintervention and 1-month follow-up time points, LARKSPUR led to greater reductions in pain (bL–bC=–0.20, 95% HPD –0.36 to –0.04) and fatigue (bL–bC=–0.24, 95% HPD –0.41 to –0.06) following PE.

Conclusions
This randomized controlled trial provides initial evidence that a web-based PA skills intervention can enhance emotional well-being and reduce pain and fatigue in aging adults with fibromyalgia.

Trial Registration
ClinicalTrials.gov NCT04869345; https://clinicaltrials.gov/study/NCT04869345
Factors Influencing Malnutrition Among Older Adult Residents in the Western Region of Saudi Arabia: Sex Differential Study
Authors: Ghabashi Mai Adil , Azzeh Firas Sultan 
Published: September 2024

Background
The global population of older adults is on the rise. As people age, their physical functions gradually decline, leading to a decrease in the overall functioning of different organ systems. Due to these changes, older individuals are at a higher risk of encountering various adverse health outcomes and complications, such as malnutrition.

Objective
This study aims to investigate the prevalence of malnutrition and its associated factors among older adults dwelling in the western region of Saudi Arabia. We have analyzed these factors separately for both men and women to understand any potential sex differences.

Methods
A nonrandomized cross-sectional study was conducted for older adults aged ≥60 years in the western region of Saudi Arabia. Personal information was obtained through a closed questionnaire. The Mini Nutritional Assessment Short Form was used to determine the malnutrition status of older adults. Consequently, the individuals were divided into 2 groups: normal and malnourished. To assess the risk factors related to malnutrition, the odds ratio (OR) and 95% CI were determined using a binary logistic regression.

Results
The prevalence of malnutrition in men and women was around 7% and 5%, respectively. Potential risk factors related to malnutrition in men were higher age (OR 1.263, 95% CI 1.086-1.468; P=.002), being widowed (OR 8.392, 95% CI 1.002-70.258; P=.049), and having dental problems (OR 9.408, 95% CI 1.863-47.514; P=.007). On the other hand, risk factors associated with malnutrition in women were lower BMI (OR 0.843, 95% CI 0.747-0.952; P=.006) and being disabled (OR 18.089, 95% CI 0.747-0.952; P=.006).

Conclusions
The findings of this study provide important insights into the risk factors for malnutrition among older adults in the western region of Saudi Arabia. While the overall prevalence of malnutrition was relatively low, the analysis revealed distinct risk factors for older men and women. Interventions developed based on the identified risk factors may prove effective in addressing the issue of malnutrition within this population.
Are All Pictures Worth 1,000 Words? An Investigation of Fit Between Graph Type and Performance on Accounting Data Analytics Tasks
Authors: Granitto Shawn P. , Murthy Uday S. 
Published: September 2024

ABSTRACT
Despite the increasing prevalence of the use of data analytics and visualizations in accounting settings, little is known about the relative effectiveness of different visualization formats for tasks such as those involving comparisons over time and those involving evaluations of whole-part compositions. In this study, we examine if there is a difference in decision efficiency and effectiveness between bar and line graphs for a comparison task and between pie and stacked column graphs for a compositional task. We also examine if the component complexity of graphs affects performance. We find that line graphs result in significantly greater decision sensitivity (ability to identify true positives) than bar graphs on comparison tasks regardless of the degree of component complexity. We also find that bar graphs result in significantly greater decision specificity (ability to identify true negatives) and overall accuracy.
Bidirectional Mendelian Randomization Highlights Causal Relationships Between Circulating INHBC and Multiple Cardiometabolic Diseases and Traits
Authors: Loh Nellie Y. , Rosoff Daniel B. , Richmond Rebecca , Noordam Raymond , Smith George Davey , Ray David , Karpe Fredrik , Lohoff Falk W. , Christodoulides Constantinos 
Published: September 2024

Human genetic and transgenic mouse studies have highlighted a potential liver-adipose tissue endocrine axis, involving activin C (Act-C) and/or Act-E and ALK7, influencing fat distribution and systemic metabolism. We investigated the bidirectional effects between circulating INHBC, which homodimerizes into Act-C, and adiposity traits, insulin resistance, inflammation, and cardiometabolic disease risk. Additionally, we examined whether Act-C is an ALK7 ligand in human adipocytes. We used Mendelian randomization and in vitro studies in immortalized human abdominal and gluteal adipocytes. Circulating INHBC was causally linked to reduced lower-body fat, dyslipidemia, and increased risks of coronary artery disease (CAD) and nonalcoholic fatty liver disease (NAFLD). Conversely, upper-body fat distribution, obesity, hypertriglyceridemia, subclinical inflammation, and type 2 diabetes positively impacted plasma INHBC levels. Mechanistically, an atherogenic lipid profile may partly explain the INHBC-CAD link, while inflammation and hypertriglyceridemia may partly explain how adiposity traits affect circulating INHBC. Phenome-wide Mendelian randomization showed weak causal relationships between higher plasma INHBC and impaired kidney function and higher gout risk. In human adipocytes, recombinant Act-C activated SMAD2/3 signaling via ALK7 and suppressed lipolysis. In summary, INHBC influences systemic metabolism by activating ALK7 in adipose tissue and may serve as a drug target for atherogenic dyslipidemia, CAD, and NAFLD.

Article Highlights
Comparison of the Efficacy of Type 2 Diabetes Group Training Courses With and Without the Integration of mHealth Support in a Controlled Trial Setting: Results of a Comparative Pilot Study
Authors: Roth Melanie , Bodenhofer Johanna , Fischill-Neudeck Magdalena , Roth Caroline , Domhardt Michael , Emsenhuber Gerlinde , Grabner Babette , Oostingh Gertie J. , Schuster Anja 
Published: September 2024

Objective
This study assessed the effects on type 2 diabetes self-management education provided in group courses with or without a supporting smartphone application (the DM2CUA app).

Research Design and Methods
This open-label, cluster-randomized, controlled, multicenter pilot study involved three Austrian diabetes educational group courses. People with type 2 diabetes in the control group received a regular educational group course, whereas those in the intervention group received the same course plus the use of the DM2CUA app. The app prompted participants to carry out educational tasks that were discussed in the course. After the last lesson, the app provided participants with relevant messages for another 4 weeks. The primary outcome measure was the Diabetes Self-Management Questionnaire score assessed at four time points. Secondary outcome measures included scores on the Diabetes Distress Scale and the Health Education Impact Questionnaire and A1C levels.

Results
Participants in the intervention group already had a higher level of diabetes self-management at the start, but the median score showed further improvement during the entire study period.

Conclusion
Findings from this pilot study suggest that the DM2CUA app may have a positive impact on diabetes self-management.
Literacy and Numeracy Questions Based on Minimum Competency Assessments to Improve the Competency of Private High School Teachers
Authors: Hari Sugiharto Setyaedhi  
Published: September 2024

Teachers at one of the private high schools are not yet skilled in preparing AKM-based literacy and numeracy questions. This research aims to test the feasibility and effectiveness of developing AKM-based literacy and numeracy questions. The feasibility test uses validation from evaluation experts, teaching materials and language, while the effectiveness test uses the t-test of the average pre-test and post-test scores. The research subjects were 80 private high school teachers in Surakarta. The experimental design in this research uses a Pre-Experimental design with a Pretest Posttest One Group Design design model. Data collection methods use observation, interviews, questionnaires and tests. This research uses an additive model. The data analysis technique was carried out descriptively qualitatively based on the validator's suggestions. Data analysis using SPSS. The results of the feasibility test validation show that there is a significant difference between the average pretest and posttest scores for literacy and numeracy. The conclusion of this research is that the development of AKM-based questions has proven to be feasible and effective in improving the competence of private high school teachers in Surakarta. The implication of this research is increasing teacher competence in developing literacy and numeracy-based questions. The implications of this research are This assessment provides clear guidance on areas that require special attention, so that training and professional development can be focused on addressing deficiencies.
KERAGAMAN DAN HERITABILITAS LIMA VARIETAS KACANG PANJANG (Vigna sinensis L) PADA BUDIDAYA ORGANIK
Authors: Khustiana Nindia Indar , Wibowo Lestari , Ginting Yohannes Cahya , Sa'diyah Nyimas 
Published: September 2024

Upaya meningkatkan produksi sayuran organik di Indonesia dapat dilakukan dengan perakitan varietas unggul baru melalui metode pemuliaan tanaman yang dibudidayakan secara organik sehingga diharapkan varietas yang dihasilkan lebih adaptif pada sistem budidaya secara organik. Parameter genetik yang mempengaruhi keberhasilan pemuliaan tanaman adalah keragaman dan nilai heritabilitas. Oleh karena itu, perlu diketahui keragaman dan nilai heritabilitas tanaman kacang panjang yang diseleksi pada lingkungan organik. Penelitian ini memiliki tujuan untuk mengetahui keragaman dan nilai heritabilitas lima varietas tanaman kacang panjang pada lingkungan organik. Penelitian ini dilaksanakan di Laboratorium Lapang Terpadu Fakultas Pertanian Universitas Lampung pada bulan Juli 2021 – Desember 2021. Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap (RAL) diulang sebanyak tiga kali dengan lima varietas kacang panjang sebagai perlakuan antara lain varietas Kanton Tavi, Megan, Janges, Persada 35 dan Top 18. Hasil penelitian menunjukkan bahwa semua karakter yang diamati : umur berbunga, diameter polong, panjang polong, jumlah polong, bobot polong, kemanisan polong, jumlah cabang produktif, jumlah biji per polong, jarak antar lokul, dan jumlah polong bagus memiliki nilai ragam fenotipe luas. Sedangkan nilai ragam genotipe sempit pada semua karakter yang diamati. Nilai heritabilitas pada karakter diameter polong, jumlah biji per polong, dan kemanisan polong termasuk dalam kriteria sedang. Varietas Kanton Tavi memiliki keunggulan dan dapat dijadikan sebagai sumber tetua pada pemuliaan tanaman di lingkungan organik.
EFEK SINERGI BIOCHAR-KOMPOS PADA TANAMAN KEDELAI (Glycine max L.) DI SAWAH
Authors: Widowati Widowati , Nursia Alicia , Fikrinda Wahyu 
Published: September 2024

Pengelolaan sawah tanpa masa istirahat serta tidak melakukan pergiliran tanaman menyebabkan berkurangnya bahan organik. Bahan organik tanah sebagai penentu kesuburan tanah agar tanah mampu menyuplai unsur hara bagi tanaman. Pupuk organik dan bahan pembenah tanah (amelioran) merupakan kombinasi yang mampu meningkatkan bahan organik tanah dan menyediakan unsur hara. Biochar-kompos memerlukan perbandingan yang tepat pada tanah sawah yang telah lama digunakan hanya untuk tanaman padi tanpa input organik. Penelitian ini bertujuan untuk mempelajari efek sinergi penggunaan biochar dan kompos pada berbagai perbandingan terhadap pertumbuhan dan hasil tanaman kedelai (Glycine max L.) di tanah sawah setelah padi. Penelitian dilaksanakan pada bulan September sampai Desember 2022 di Dusun Bawang, Kelurahan Tunggul Wulung, Kecamatan Lowokwaru, Kota Malang. Penelitian menggunakan Rancangan Acak Kelompok (RAK) non faktorial terdiri atas 7 perlakuan dengan 3 ulangan yaitu K0 (tanpa biochar dan kompos), K1 (20% biochar dan 80% kompos), K2 (40% biochar dan 60% kompos), K3 (60% biochar dan 40% kompos), K4 (80% biochar dan 20% kompos), K5 (100% biochar) dan K6 (100% kompos). Persentase biochar dan kompos didasarkan atas penggunaan pada dosis sebanyak 500 g/polybag. Penggunaan 20% biochar dan 80% kompos menunjukan hasil panen yang paling tinggi yaitu 3,55 t/ha. Sebagian besar menunjukan korelasi positif dan hubungan kuat antara karbon organik, nitrogen, fosfor, dan kalium di dalam tanah dengan komponen hasil dan hasil kedelai.
Pharmacokinetics and sedative effects of single-dose oral gabapentin in cheetahs (Acinonyx jubatus)
Authors: Peel Melanie J. , Knych Heather , Kinney Matthew E. , Nevitt Benjamin , Edell Analisa , Taylor Sandra L. , Akinjobi Zainab , Gjeltema Jenessa 
Published: September 2024

Abstract

OBJECTIVE
To assess the pharmacokinetics and sedative effects of a single administration of oral gabapentin in African cheetahs (Acinonyx jubatus) at 2 different dosages.

METHODS
Adult cheetahs (n = 16) located at 3 different zoological institutions were prospectively enrolled to receive single doses of gabapentin administered at 2 different dosages (10 mg/kg and 20 mg/kg). Venipuncture was performed under behavioral restraint at predetermined time points over a 24-hour period using a sparse sampling model. Plasma concentrations of gabapentin were determined using high-performance liquid chromatography. A modified domestic felid sedation scoring system was used to assess animals at each time point by 3 masked scorers, and sedation scores were compared between time points.

RESULTS
Mean ± SE maximal plasma concentrations were 24.0 ± 12.8 μg/mL and 31.4 ± 8.57 μg/mL for the 10- and 20-mg/kg dosages, respectively. For both dosages, concentrations remained elevated at the final collection time point of 24 hours (2.39 ± 1.97 and 3.93 ± 3.09 μg/mL for 10 and 20 mg/kg, respectively). Mild sedation was achieved for both doses up to 24 hours postadministration, with no significant differences between dosages.

CONCLUSIONS
Gabapentin was well absorbed following oral administration, and concentrations remained elevated 24 hours postadministration. Gabapentin produces mild sedation at 10 or 20 mg/kg for up to 24 hours.

CLINICAL RELEVANCE
Gabapentin given to cheetahs at these dosages is a useful tool for improving patient welfare due to its mild sedative effects over a clinically relevant time period.
Efficacy of sorafenib plus transcatheter arterial chemoembolization in treating hepatocellular carcinoma with portal vein tumor thrombosis: A meta-analysis
Authors: Xu Li , Chen Shanshan , Cao Haijun , Feng Zemin , Yang Chao 
Published: September 2024

Abstract
This meta-analysis aimed to evaluate the efficacy of sorafenib plus transcatheter arterial chemoembolization (TACE) in treating hepato-cellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). Twelve randomized controlled trials published until 28th Sep 2022 were finally included. Of the total 1746 patients, of whom 458 received sorafenib and TACE treatment (Group S+TACE), and 1288 only underwent TACE (Group TACE), were enrolled. Outcomes including time to progression (TTP), objective response rate (ORR), disease control rate (DCR), overall survival (OS), survival rate (SR), and adverse reactions, were extracted. The OS (HR: 0.596, 95 %CI: 0.507–0.685, p < 0.001; I2 = 0.0 %) and TTP (HR: 0.379, 95 %CI: 0.205–0.553, p < 0.001; I2 = 4.5 %) in the S+TACE group were longer than those in the TACE group. The ORR (RR: 2.101, 95 %CI: 1.555–2.839, p < 0.001; I2 = 0.0 %), DCR (RR: 1.547, 95 %CI: 1.126–2.126, p = 0.007; I2 = 79.6 %) and SR (RR: 1.416, 95 %CI: 1.183-1.694, p < 0.001; I2 = 83.8 %) in the S+TACE group were higher than those in the TACE group. Compared with the TCAE group, the higher odds of HFSR, oral ulcer, and diarrhea among patients with HCC complicated by PVTT were discovered in the S+TACE group. The marginal significance was found in ascites and gastrointestinal bleeding between the two groups. Sorafenib plus TACE has good efficacy and mild adverse reactions, which may be worthy of clinical promotion.
The Influence of Injection Mode and Spray Distance on Wear Resistance of Al2O3+13 wt.% TiO2 coatings
Authors: Płatek Karolina , Łatka Leszek , Nowakowska Monika 
Published: September 2024

Abstract
Atmospheric plasma spraying (APS) allows deposition of ceramic coatings on metallic substrate, significantly increasing the wear resistance of the component. Coating’s microstructure and consequently its properties, depend on heat treatment of the feedstock particles. This property can be controlled by process parameters, especially electric power and spray distance. On the other hand, some plasma torches allow introducing another variable, an injection mode, which could be realized in external or in internal way. In the presented research, wear resistance of Al2O3+13 wt.% TiO2 coatings deposited under various values of spray distance and different injection modes were examined using ASTM G-99 procedure. The impact of spraying parameters on the coating’s microstructure was established and connected to the functional properties of the manufactured deposits. Observed differences indicated influence of injection mode and spray distance value. Coatings deposited with internal feedstock injection exhibit lower porosity and slightly higher hardness than these made with external injection mode. In terms of wear resistance for both spray distance the wear factor was lower for internal injection system. Obtained results confirmed assumed thesis, that internal injection mode improves heat treatment and consequently ameliorate wear performance of plasma sprayed alumina-titania coatings.