bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of gelatin nanoparticles for positron emission tomography diagnosis in pancreatic cancer
Authors: Sugo Yumi , Kimura Atsushi , Koizumi Tomoya , Oyama Kotaro , Taguchi Mitsumasa 
Published: September 2024

Abstract
Pancreatic cancer remains difficult to diagnose using currently available imaging probes. Thus, this study aimed to develop a novel imaging agent for the diagnosis of pancreatic cancer using positron emission tomography (PET). Specifically, this study explores gelatin-based nanoparticles fabricated via radiation-induced crosslinking, as gelatin is known for its ability to produce biocompatible materials. Aqueous gelatin solutions were irradiated with γ-rays to produce nanoparticles with average diameters of 5–20 nm via a radiation crosslinking technique. The gelatin nanoparticles were labeled with 64Cu, exhibiting negative surface potentials. Furthermore, the nanoparticles were evaluated in vivo by injecting them into pancreatic tumor-bearing mice. Notably, the nanoparticles accumulated in the tumors. Hence, 64Cu-labeled gelatin nanoparticles show promise as a platform for next-generation PET imaging agents for pancreatic cancer.
Cationic Gemini surfactants: a review on synthesis and their applications
Authors: Naik Bharti , Paranjpe Susmita S. , Madankar Chandu S. 
Published: September 2024

Abstract
The molecules of Gemini surfactants are dimeric and consist of two monomeric surfactant units linked by a spacer. Among them, cationic Gemini surfactants have a wide range of application in various industrial sectors such as pharmaceuticals, home and personal care, corrosion inhibition, etc. Various methods of synthesis have been investigated and tested for the synthesis of cationic Gemini surfactants. The surface properties of Gemini surfactants are highly dependent on various factors like spacer, headgroups, counterions, etc. The cationic Gemini surfactants have lower CMC values as compared to their monomeric analogues. This review highlights the different methods for the synthesis of cationic Gemini surfactants and the applications of these surfactants in different fields are presented.
A tale of two sisters – delayed diagnosis of genetic hyperinsulinaemic hypoglycaemia
Authors: Stringer F , Preston C , MacIsaac R , Inchley F , Rivera-Woll L , Farrell S , Sachithanandan N 
Published: September 2024

Summary
Congenital hyperinsulinism is the leading cause of persistent hypoglycaemia in infants and children; however, it is uncommon to be diagnosed in adulthood. We describe the cases of two sisters who presented with hyperinsulinaemic hypoglycaemia aged 47 and 57 years old, who were subsequently diagnosed with compound heterozygous likely pathogenic variants in the ABCC8 gene, a known cause of monogenic congenital hyperinsulinism. We discuss the typical presenting features, investigation findings, and treatment strategies for patients with this condition.

Learning Points

Congenital hyperinsulinism is a rare cause of hyperinsulinaemic hypoglycaemia diagnosed in adulthood.

Clinical presentation is similar to an insulinoma, and imaging modalities may assist in differentiation.

There are minimal medical therapies currently available for patients non-responsive to diazoxide (such as those with ABCC8 and KCNJ11 variants).

Continuous glucose monitoring can be helpful in giving patients autonomy in managing their disease, as well as relieving anxiety and fear associated with hypoglycaemia.
Implementation of TQM in The Context of Patient Satisfaction in Various Hospitals in Indonesia
Authors: Tedjakusuma Abigail Sulistyani , Wulansari Candra Fitri , Sinaga Grace Krisdayanti , Winata I Putu Arya , Muslimin Mun Randi , Fermina Oktaviana Linda , Pinesa Venda Happy , Veranita Mira , Purwadhi  
Published: September 2024

Introduction: The quality of healthcare in Indonesia has become a crucial factor in ensuring the well-being and satisfaction of patients. In the face of complex challenges in organizing and improving the quality of services to meet the increasingly diverse needs of society, patient satisfaction is a key indicator in assessing service quality. Total Quality Management (TQM) has emerged as a promising approach to improving healthcare institutions' efficiency, effectiveness, and patient satisfaction. This review describes the relationship between TQM implementation and patient satisfaction levels in Indonesian healthcare institutions.
Method: Using the literature review method, this research systematically summarizes relevant findings, aiming to provide greater insight into the impact of TQM on patient experience. The literature examination included understanding the basic concepts of TQM, its principles, and experiences of its application in the context of healthcare institutions. The literature analysis also focused on previous studies addressing the relationship between TQM implementation and patient satisfaction.
Result: Total Quality Management (TQM) implementation significantly improves the quality of healthcare services and, in an indirect context, contributes to improved patient satisfaction. Measures such as active patient participation, effective communication, and a continuous focus on quality improvement have been shown to play a crucial role in increasing patients' positive perceptions of healthcare services.
Conclusion: The implications of the results of this study provide direction for further research and contribute to the existing literature on healthcare management and quality improvement.
Identifying the effect of subgrade layer thickness of soil stabilized with waste foundry sand and fly ash on bearing capacity
Authors: Gunarti Anita Setyowati Srie , Zaika Yulvi , Munawir As’ad , Suryo Eko Andi , Harimurti Harimurti 
Published: September 2024

The issue of subgrade soil often involves unstable soil properties, such as low bearing capacity, susceptibility to expansion and shrinkage, and vulnerability to erosion and deformation due to traffic loads and weather conditions. Unstable subgrade soil can cause various infrastructure problems, including cracks, settlement, and damage to road surfaces. Therefore, stabilizing subgrade soil is an important step to ensure the reliability and longevity of highways. One effective and sustainable method for subgrade soil stabilization is by utilizing local waste materials. The use of local waste materials such as fly ash (FA) and waste foundry sand (WFS) not only improves the physical and mechanical properties of the soil but also helps reduce environmental impact by repurposing pollutants. This study aims to analyze the effect of the thickness of subgrade layers stabilized with FA and WFS on bearing capacity. The initial stage includes examining the physical and mechanical properties of natural soil and soil stabilized with FA and WFS. The waste content used is 9 % FA and 15 % WFS by dry weight of the soil. Subgrade modeling was conducted using a steel box measuring 60×60×60 cm with a soil thickness of 30 cm. Load testing was carried out on 5 layer variants that had undergone 4 days of curing. The study results found that the ultimate bearing capacity (qult) of 890 kPa was produced by the V4 layer, which is a subgrade with a 30 cm thick layer of soil stabilized with FA and WFS at a settlement of 6 mm. The bearing capacity ratio of 2.87 means that the subgrade with a 30 cm thick layer of soil stabilized with FA and WFS experienced an improvement in bearing capacity of 2.87 times that of the subgrade with untreated soil material. The results obtained can be applied in practice to the local geotechnical conditions of the project site in West Java, including natural soil properties and seasonal changes
Improvement the dielectric and impedance properties of Pb-free Bi0.5Na0.5TiO3-SrTiO3 piezoelectric materials modified by Fe2O3
Authors: Effendi Mukhtar , Rini Nugraheni Puspita , Kurniawan Candra , Cahyanto Wahyu Tri , Widanarto Wahyu 
Published: September 2024

The focus of this study is on the Fe2O3-doped Bi0.5Na0.5TiO3-SrTiO3 piezoelectric material. This is important to find ecologically acceptable piezoelectric materials. This research aims to obtain a lead-free piezoelectric material because lead is a material that is not environmentally friendly. An alternative solution is a piezoelectric material based on BNT-ST, which in this case is doped with Fe2O3 material. The study of Fe2O3 doped Bi0.5Na0.5TiO3-SrTiO3 piezoelectric material prepared by the solid-state reaction method was carried out to determine the optimum composition of the material formed. Doping variations are 0; 2.5; 5; 7.5; and 10 in mol %. The examinations were performed using X-ray diffraction (XRD) spectroscopy, a Scanning Electron Microscope (SEM), and an LCR meter. The Fe2O3 doped Bi0.5Na0.5TiO3-SrTiO3 produced a new compound in the form of FeBi5Ti3O15-Na2Ti3O7-SrTiO3 with the crystal structure of cubic, orthorhombic, and monoclinic, as well as the increasing crystalline size with the addition of dopants, exclude at 5 mol % and 7.5 mol %. FeBi5Ti3O15-Na2Ti3O7-SrTiO3 also produces varying particle sizes, which are between 0.88–8.23 µm. From the obtained data, the optimum composition of Fe2O3 doped Bi0.5Na0.5TiO3-SrTiO3 was the 2.5 mol % of Fe2O3 due to it having the highest dielectric constant (er ) and temperature Curie (Tc ), and also the lowest material impedance (Z) with the er of 12.037 at Tc of 400 °C and Z of 135 kΩ. The high piezoelectricity, which is indicated by the high value of the dielectric constant and Curie temperature, is possible due to the presence of a greater number of sodium ions in the Na2Ti3O7 phase. Sodium ions are ions with good electrical storage capabilities. The increase in dielectric constant in the BNT-ST piezoelectric obtained by the addition of Fe2O3 shows that this material can be used as a substitute for lead-based piezoelectric materials so that it is secure for the environment. The piezoelectric material of BNT-ST doped with Fe2O3 earned from this research can be applied to obtain electricity with a optimal value when given mechanical pressure
Devising a calculation method for modern structures of current-conducting elements in large electric machines in a three-dimensional statement
Authors: Tretiak Oleksii , Smyk Serhii , Kravchenko Stanislav , Smakhtin Serhii , Brega Dmytro , Zhukov Anton , Serhiienko Serhii , Don Yevhen 
Published: September 2024

The jumpers of rotor pole-to-pole connections are highly stressed elements in a hydraulic generator structure. These assemblies often fail due to deformation that exceeds the size of an air gap. Existing methods do not take into account the thermal component and attempts to improve the design are not based on mathematical models that make it possible to perform calculations with an accuracy of more than 50 %. The method devised in this work makes it possible to obtain boundary conditions of the third kind on the basis of three-dimensional mathematical modeling of the ventilation system of the hydraulic unit without simplifications. The method accuracy is explained by taking into account the spatial thermal component. The heat transfer coefficient determined by this method in the pole-to-pole connections area was ~250 W/(m2·K). Using FEM, mathematical modeling of the thermal stress state of pole-to-pole connections was carried out, taking into account mechanical and thermal factors. This made it possible to design the improved connection structure with additional fastening elements, which make it possible to reduce the displacement to 0.03 mm, and the stress to 53 MPa at the rotor rotation frequency of 880 rpm. This design makes it possible to enable reliable operation of the hydraulic unit under the condition of increasing the rotor rotation frequency to overspeed with disconnected combinatorial dependence, provided that the actual stresses are 0.95 % of the material yield strength. The convergence of the values obtained by the proposed method and by the HSS method exceeded 99 %. The practical result is the proposals for the hydraulic generator design modernization
Segmentation of image from a first-person-view unmanned aerial vehicle based on a simple ant algorithm
Authors: Khudov Hennadii , Hridasov Illia , Khizhnyak Irina , Yuzova Iryna , Solomonenko Yuriy 
Published: September 2024

The object of this study is the process of image segmentation from the First Person View (FPV) of an unmanned aerial vehicle (UAV). The main hypothesis of the study assumes that the use of a simple ant algorithm could ensure the necessary quality of the segmented image.
The segmentation method, unlike the known ones, takes into account the number of ants in the image, weight, initial amount and evaporation rate of the pheromone, the "greediness" of the algorithm and provides:
– preliminary selection of individual channels of the Red-Green-Blue (RGB) color space;
– preliminary placement of ants according to the uniform law;
– determining the routes of ants;
– taking into account the attractiveness of the route for each ant;
– change (adjustment) in the concentration of ant pheromones;
– calculation of the probability of movement (transition) of the ant on the movement route;
– determination of the objective function at the j-th iteration and its minimization;
– determining the coordinates of the route of movement (movement) of ants;
– verification of the fulfillment of the stop condition;
– determination of the best routes found by ants;
– calculation of the brightness of the pixels of the segmented image in each channel of the RGB color space;
– further combining the results of channel segmentation.
An experimental study of image segmentation from UAV FPV based on a simple ant algorithm was conducted. The specified object of interest on the segmented image has a certain structure, unevenness of the contours, and can be further used for decoding, categorization, etc. Unlike the object of interest, the background ("garbage" objects) in the segmented image do not have a stable structure and can be further filtered out.
It has been established that the segmented image by the known method based on the gradient module has a low contrast value, there are gaps in the segmented pixels of the object of interest. A segmented image using a method based on a simple ant algorithm is free from that drawback.
ELECTROPHYSIOLOGICAL MEASURES OF AUDITORY IMPAIRMENT IN NOISE-EXPOSED, NORMAL-HEARING SOLDIERS
Authors: Sargsyan Gayane H. , Garabedian Erea-Noel , Bakhshinyan Vigen , Ananyan Gnel , Mesropyan Hayastan , Morsikyan Irina , Aghababyan Armine , Simonyan Svetik , Sargsyan Sona , Shukuryan Arthur 
Published: September 2024

IntroductionSome electrophysiological changes can occur in the auditory system in response to noise exposure with or without any permanent auditory threshold shift. The purpose of this study was to identify and measure cochlear function after noise exposure in individuals with
normal hearing according to standard audiometric thresholds.Material and methodsPure tone audiometry (PTA) over the standard 0.250–8 kHz range and at 12 kHz, as well as distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) testing, were performed on 42 soldiers who had participated in combat. A control group of 40 participants underwent the same tests.ResultsIn the noise-exposed group, significantly poorer PTA thresholds were recorded at 12 kHz. DPOAE levels were significantly low only at 4 kHz. On ABR testing, both wave I and wave V demonstrated a significant decrease in amplitude and a significant increase in latency for
the noise-exposed group.ConclusionsOur findings reveal that high levels of noise can not only damage outer hair cells but also cause changes at the level of the synapses (synaptopathy) which are not evident using standard PTA tests. However, electrophysiological methods can detect some changes in cochlear function.
HYBRID LEARNING: STRATEGI PENYELENGGARAAN PEMBELAJARAN PASCA PENERAPAN KEBIJAKAN PTMT DI MASA PANDEMI COVID-19
Authors: Vonny Vonny , Shiyama Fariha , Supriyatin Supriyatin 
Published: September 2024

Penyelenggaraan pendidikan di masa pandemi covid-19 menuntut terjadinya penyesuaian dan perubahan kebijakan yang sangat drastis. Kebijakan awal penyelenggaraan pendidikan di sekolah, berupa pembelajaran jarak jauh, yang menuntut pengadopsian pembelajaran berbasis online yang sudah lama dikenal dengan online learning. Namun demikian, tidak semua sekolah memiliki kesiapan cukup untuk menyelenggarakan online learning, sehingga banyak kekurangan terjadi dalam pelaksanaannya. Setelah kasus covid-19 berkurang, melalui berbagai evaluasi, kebijakan Pertemuan Tatap Muka Terbatas (PTMT) diberlakukan. Kebijakan PTMT diterapkan oleh setiap satuan pendidikan dengan pendekatan yang bervariasi. Penelitian ini memberikan gambaran deskriptif mengenai penyelenggaraan pembelajaran di beberapa sekolah pasca diterapkannya kebijakan PTMT, serta pendapat guru mengenai pelaksanaan penyelenggaraan kebijakan tersebut di sekolah masing-masing. Data diambil melalui survey yang disebarkan secara acak, dan didapatkan 82 responden dari berbagai sekolah. Validasi butir pertanyaan dihitung dengan menggunakan rumus alpha cronbach pada tingkat signifikansi 5%. Hasil penelitian menunjukkan bahwa setelah kebijakan PTMT diberlakukan, 49% satuan pendidikan menyelenggarakan pembelajaran hybrid learning, 38% menyelenggarakan pembelajaran tatap muka di kelas dengan dua gelombang, 10% menyelenggarakan pembelajaran online untuk siswa yang belajar di rumah, dan tatap muka di kelas pada waktu yang berbeda, sedangkan 4% melakukan kebijakan yang bervariasi lainnya. Dari sudut pandang guru, kebijakan PTMT dinilai memberikan keuntungan pada beberapa aspek. Secara khusus, pada pembelajaran hybrid learning, guru dituntut untuk mampu membagi atensi terhadap siswa yang belajar di rumah dan di sekolah, serta persiapan yang lebih untuk mendesain pembelajaran.
Implementation of the Cooperative Learning Model to Develop Soft Skill Aspects in Elementary School Students
Authors: Zahra Zhaffa Ramadhani , Hendracipta Nana , Pribadi Reksa Adya , Hakim Zerri Rahman 
Published: September 2024

The current shift in the educational paradigm can be observed in Indonesia's emphasis on developing 21st-century skills. Soft skills are now a criterion for the quality of human resources, and their acquisition must be habitual. This can begin with classroom learning activities as well as supporting activities outside of the classroom. The purposes of this research were, therefore, to 1) analyze the learning process using the cooperative learning model, 2) apply the cooperative learning model to analyze supporting and inhibiting factors for learning activities, and 3) describe the impact of using the cooperative learning model on developing soft skills in class V students at the Islamic Integrated Elementary School of Irsyadul Ibad, particularly in the class of Hanzalah. In this study, descriptive methods were combined with a qualitative approach, and the data were gathered as a set of words and images. The data from observation, documentation, and interview sources were thus analyzed by the researchers in this study. The study's findings demonstrated that: 1) Students' soft skills can be developed in the classroom using the cooperative learning model. 2) Activities outside of learning, such as extracurricular activities, can help students develop their soft skills. 3) The cooperative learning model can be used to teach students basic skills like communication, self-confidence, cooperation, creativity, and critical attitudes.
Implementation of clinical supervision with a collaborative approach to enhance teachers’ pedagogical competence in junior high schools
Authors: Bali Alfonrianus , Iriani Ade 
Published: September 2024

Clinical supervision is a systematic approach to mentoring professional teachers. This research aims to improve teachers' pedagogical competence at Bintang Laut Telukdalam Private Middle School through the implementation of clinical supervision with a collaborative approach by the school principal. This type of research is school action research. This research used the Kemmis and Tagart model, which is carried out in 4 stages: planning, implementation or action, observation, and reflection. Data collection techniques used by the researcher are interviews, observation, documentation, and questionnaires. The results of the research show that the implementation of clinical supervision with a collaborative approach by the principal can increase the pedagogical competence of teachers at Bintang Laut Telukdalam Private Middle School, which can be proven by increasing the average teacher pedagogical competency score, namely: before providing clinical supervision the average competency score teacher pedagogy was 63, after providing clinical supervision it increased to 78 in cycle I and 81 in cycle II which was above the specified success criteria, namely 75. From these results, it can be concluded that implementing clinical supervision with a collaborative approach can increase teachers' pedagogy competency at Bintang Laut Telukdalam Private Middle School. AbstrakSupervisi klinis adalah suatu pendekatan yang sistematis dalam pembinaan profesional guru. Penelitian ini bertujuan untuk meningkatkan kompetensi pedagogik guru SMP Swasta Bintang Laut Telukdalam melalui penerapan supervisi klinis dengan pendekatan kolaboratif oleh kepala sekolah. Jenis penelitian ini merupakan penelitian tindakan sekolah. Penelitian ini menggunakan model Kemmis dan Tagart yang merupakan sebuah model penelitian yang dilakukan dengan 4 tahap yaitu perencanaan, pelaksanaan atau tindakan, observasi dan refleksi. Hasil penelitian menunjukkan bahwa pelaksanaan supervisi klinis dengan pendekatan kolaboratif oleh kepala sekolah dapat meningkatkan kompetensi pedagogik guru SMP Swasta Bintang Laut Telukdalam yang dapat dibuktikan dengan peningkatan rata-rata nilai kompetensi pedagogik guru yaitu: sebelum pemeberian tindakan supervisi klinis dengan pendekatan kolaboratif rata-rata nilai kompetensi pedagogik guru 63, setelah pemberian tindakan supervisi klinis dengan pendekatan kolaboratif meningkat menjadi 78 pada siklus I dan 81 pada siklus II yang berada di atas kriteria keberhasilan yang ditentukan yaitu 75. Dari hasil tersebut maka dapat disimpulkan bahwa pelaksanaan supervisi klinis dengan pendekatan kolaboratif dapat meningkatkan kompetensi pedagogik guru SMP Swasta Bintang Laut Telukdalam.Kata Kunci: kompetensi pedagogik guru; pendekatan kolaboratif; supervisi klinis