bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI-Based Multi-Class Relevance Vector Machine Classification of Neurodegenerative Diseases
Authors: Younes Kyan , Cobigo Yann , Wolf Amy , Kornak John , Rankin Katherine P. , Faisal Beg Mirza , Wang Lei , Rosen Howard J. 
Published: October 2024

AbstractMachine learning algorithms are a promising automated candidate that can help mitigate the growing need for dementia experts. Despite the substantial development in MRI-based machine learning analyses, case misclassification is a universal finding, yet the reasons behind misclassification are poorly understood. We implemented a multi-class classification approach that uses relevance vector machine and logistic classification to classify research participants based on their whole-brain T1-weighted MRI scans. A total of 468 participants from seven diagnostic classes were included: 144 healthy controls, 84 Alzheimer’s disease, 108 behavioral variant frontotemporal dementia (bvFTD), 30 semantic variant primary progressive aphasia (svPPA), 30 non-fluent variant primary progressive aphasia (nfvPPA), 30 corticobasal syndrome (CBS), and 42 progressive supranuclear palsy syndrome (PSPS). We compared the algorithm‘s diagnostic accuracy against the clinical, pathological, genetic, and quantitative imaging data. The exact neurodegenerative syndrome was predicted in 71% of the cases, the neurodegenerative disease spectrum was predicted in 80% of the cases, and the algorithm distinguished controls from any dementia in 85% of the cases. The algorithm showed high performance in diagnosing healthy controls, moderate performance in diagnosing AD, bvFTD, and svPPA, and low performance in diagnosing CBS, nfvPPA, and PSPS. Based on the quantitative imaging data, most of the misclassified neurodegenerative cases had minimal atrophy and brain volumes comparable to healthy controls. In AD, early-onset AD cases with minimal brain atrophy represented most of the misclassified cases. In bvFTD, FTD genetic mutation carriers (predominantlyC9orf72repeat expansion), FTD phenocopy, patients meeting only possible bvFTD criteria represented most misclassified cases. Case misclassification in machine learning studies in neurodegenerative diseases results from neurodegenerative disease heterogeneity and the limitations of structural MRI’s ability to capture the whole gamut of biological changes. Larger and more inclusive datasets that are representative of population biologic heterogeneity are needed to train better machine learning techniques, and a margin of error is expected and should be acceptable, like the uncertainty of a clinical diagnosis by a dementia expert.
Task relevance selectively modulates sensorimotor adaptation in the presence of multiple prediction errors
Authors: Shingane Somesh N , Rao Nishant , Kumar Neeraj , Mutha Pratik K 
Published: October 2024

ABSTRACTAdaptation to consistently occurring sensorimotor errors is considered obligatory in nature. We probed the robustness of this finding by asking if humans can selectively attenuate adaptation based on the task-relevance of error signals. Subjects made planar reaches to three different targets: an arc (Experiment 1), a bar (Experiment 2), and a point (Experiment 3). During the reach, perturbations in extent (visuomotor gain), direction (visuomotor rotation) or both simultaneously were employed. In Experiment 1, subjects showed robust adaptation to the rotation when reaching to the arc even though the presence of this perturbation was irrelevant for achievement of the task goal. Interestingly however, rotation adaptation was strongly attenuated when it was presented simultaneously with a task-relevant gain perturbation. In Experiment 2, which involved reaches to the bar, again, subjects successfully adapted to the task-irrelevant gain perturbation when it occurred in isolation. However, adaptation was attenuated when the gain co-occurred with a task-relevant rotation. Experiment 3 revealed that the attenuation observed in the first two experiments was not due to an inability to adapt to co-occurring rotation and gain perturbations. Collectively, our results suggest that the sensorimotor system selectively tunes learning in the presence of multiple error signals, a finding that can potentially be explained by a biased competition mechanism. That is, given limited processing capacity, a salient attribute – the relevance of the error to the task goal in this case – is prioritized for processing and drives subsequent adaptive changes in motor output.NEW AND NOTEWORTHYThe motor system continuously uses error feedback to recalibrate movements in response to changes in body and environmental conditions. Such error-based adaptation is thought to be obligatory, occurring whenever error signals are present, and even if the learning interferes with achievement of the task goal. Contrary to this classical view, we demonstrate selective modulation of motor adaptation in the presence of multiple error signals based on their task-relevance.
TAOK2 Drives Opposing Cilia Length Deficits in 16p11.2 Deletion and Duplication Carriers
Authors: Ferreccio Amy , Byeon Sujin , Cornell Moira , Oses-Prieto Juan , Deshpande Aditi , Weiss Lauren A , Burlingame Alma , Yadav Smita 
Published: October 2024

ABSTRACTCopy number variation (CNV) in the 16p11.2 (BP4-BP5) genomic locus is strongly associated with autism. Carriers of 16p11.2 deletion and duplication exhibit several common behavioral and social impairments, yet, show opposing brain structural changes and body mass index. To determine cellular mechanisms that might contribute to these opposing phenotypes, we performed quantitative tandem mass tag (TMT) proteomics on human dorsal forebrain neural progenitor cells (NPCs) differentiated from induced pluripotent stem cells (iPSC) derived from 16p11.2 CNV carriers. Differentially phosphorylated proteins between unaffected individuals and 16p11.2 CNV carriers were significantly enriched for centrosomal and cilia proteins. Deletion patient-derived NPCs show increased primary cilium length compared to unaffected individuals, while stunted cilium growth was observed in 16p11.2 duplication NPCs. Through cellular shRNA and overexpression screens in human iPSC derived NPCs, we determined the contribution of genes within the 16p11.2 locus to cilium length. TAOK2, a serine threonine protein kinase, and PPP4C, a protein phosphatase, were found to regulate primary cilia length in a gene dosage-dependent manner. We found TAOK2 was localized at centrosomes and the base of the primary cilium, and NPCs differentiated from TAOK2 knockout iPSCs had longer cilia. In absence of TAOK2, there was increased pericentrin at the basal body, and aberrant accumulation of IFT88 at the ciliary distal tip. Further, pharmacological inhibition of TAO kinase activity led to increased ciliary length, indicating that TAOK2 negatively controls primary cilium length through its catalytic activity. These results implicate aberrant cilia length in the pathophysiology of 16p11.2 CNV, and establish the role of TAOK2 kinase as a regulator of primary cilium length.
Behind closed doors: unveiling earnings management in private subsidiaries of public firms
Authors: Priyesh V.P. , Jijo Lukose P.J. 
Published: October 2024

PurposeThis study examines the earnings quality of private-subsidiary firms using a large sample data from India.Design/methodology/approachThe impact of parent–subsidiary relationship on earnings quality is examined using two common proxies. Findings are robust to alternative research designs, including different earnings quality proxies, endogeneity and matching techniques.FindingsThe study finds that private firms that are subsidiaries of listed firms tend to have lesser (greater) earnings quality (manipulation). Further, the study reports that this relationship is more pronounced when the parent firm is relatively larger than the subsidiaries. The study finds no evidence that Big 4 affiliation of the parent company improves earnings quality among private subsidiaries; instead, it exacerbates earnings manipulation in some cases. Finally, the authors document that subsidiary firms use tax management, as proxied by book tax differences, to engage in income-increasing earnings manipulation.Research limitations/implicationsThis study examines how affiliation with a listed entity as a subsidiary impacts the earnings quality of private companies. Future research could investigate the financial reporting practices of both private subsidiary firms and standalone private firms, comparing them in similar or differing regulatory environments across various countries.Practical implicationsThe findings of this study will help investors, bankers, creditors and regulators to understand the financial reporting of private firms. The study calls for enhanced audit quality at the subsidiary level by making the auditor of the parent firm responsible for auditing a subsidiary, a practice that is currently absent in India.Originality/valueThe results contribute to the existing debate on how firms manage earnings using data of private firms in a large emerging market setting. Previous research has not paid enough attention to the earnings quality of private subsidiaries. The study also emphasizes the necessity for a more robust system of governance and supervision for private firms, particularly in India and generally in other countries.
A strategic evaluation of BIM-driven information management in the context of ISO 19650-2 standard
Authors: Kaya Uğur , Özener Ozan Önder 
Published: October 2024

PurposeThis paper presents an in-depth evaluation of BIM-driven information management in the context of ISO 19650-2. The study aimed to understand and evaluate the existing mechanisms and the recommended activities and tasks of collaborative information management, particularly as the Turkish AEC organizations are currently implementing ISO 19650-2.Design/methodology/approachThe study employed a qualitative research design based on information management stages of ISO 19650-2. Semi-structured interviews were conducted with purposefully selected professionals. The framework analyses were made with MAXQDA through conceptual coding to identify current drivers, challenges and incentives for BIM-driven information management. The frequencies of common themes, required tasks and semantic relationships were reported systematically and interpreted to provide a conceptual implementation map, practical insights and actionable recommendations.FindingsThe study results encompass strategies for establishing new tasks and implementation procedures to uphold business value by aligning information management standards with evolving project requirements, providing detailed and responsive EIRs, early use of CDEs, compliant production methods, clarity of roles and responsibilities, increased organizational capacity and capabilities, sustained planning and production quality and leveraging lessons learned.Originality/valueThe study provides evidence-based arguments and strategic insights for BIM-driven information management, focusing on the current implementation compatibilities with ISO 19650-2. Findings and discussions highlight the necessity of industry-wide transformations, reengineered activities/tasks and compliant information flows, which are crucial for adopting ISO 19650-2 and the formulation of national annex documents.
Signaling trust during disruptions: perceived gender differences in trustworthy leadership traits
Authors: Belasen Alan T. , Belasen Ariel R. 
Published: October 2024

Purpose
This study aims to examine differences in the self-perception and value of four traits associated with trustworthiness: transparency, credibility, accountability and honesty to find out whether these traits are more likely to be adopted by female leaders during episodes of disruption.

Design/methodology/approach
Regression estimation of perceived trustworthy leadership values using a survey of full-time employed men and women in management working for various organizations.

Findings
Honesty emerged as the highest rated trait overall, both in the respondents’ self-measure and in their reflected level of desirability. However, women described their honesty as higher than how men relayed their honesty score. Both genders rated their own transparency as their lowest scoring trait and treated it as the least important of the desired traits. Relative to men, not only do women espouse to greater levels of honesty and value it more but they also appear to embrace honesty in their desired behaviors more highly.

Research limitations/implications
A natural extension of this study is to design a longitudinal study to show causality or whether socialized gender differences, in fact, play a role in measuring the value of trustworthy leadership during disruptions.

Practical implications
Understanding self-perceptions of leaders’ efficacy and desired expectations helps prepare both current and future leaders to regain followers’ trust, especially during disruptions. Lessons learned to date require investments in building awareness of leaders’ perceptions of trustworthiness and developing relevant skills for dealing with disruptions.

Originality/value
This research adds further insight to leadership studies by establishing a linkage between characteristics of trustworthy leadership and the ability to lead in challenging times. Cultivating traits of transparency, accountability, credibility and honesty enables leaders to develop the skills needed to be viewed as trustworthy and be prepared for the unexpected.
Sustainable entrepreneurship: examining stimulus-organism-response to the nexus of environment, education and motivation
Authors: Chahal Jyoti , Dagar Vishal , Shoukat Muhammad Haroon 
Published: October 2024

PurposeThe multidimensional decision-making framework of sustainable entrepreneurship affects student behavior in higher education institutions. Thus, the sustainable entrepreneurship environment has long attracted scholars and policymakers. Based on “Stimulus Organism Response (SOR),” this study examines serial mediation of sustainable entrepreneurial education and entrepreneurial motivation to link sustainable entrepreneurial environment and intentions. Further, it also explored the moderating role of a sustainable entrepreneurial environment.Design/methodology/approachA quantitative study was conducted with a sample of 408 students of Indian higher education institutes in NCR using a purposive sampling technique. Smart PLS-SEM was utilized for assessing the structural model, and a goodness-of-fit assessment was done with Amos 22.FindingsThe findings revealed the significant impact of a sustainable entrepreneurial environment on sustainable entrepreneurial education, motivation and sustainable entrepreneurial intentions. Furthermore, sustained entrepreneurial education has the most important influence on student motivation and considerable serial mediation. Also, the moderating role of a sustainable entrepreneurial environment was found to be significant for linkages of entrepreneurial motivation and sustainable entrepreneurial education with sustainable entrepreneurial intentions.Practical implicationsThe study will assist HEIs and scholars in understanding the role of sustainability in entrepreneurial courses to increase student intentions to start sustainable businesses.Social implicationsThis study helps policymakers and HEIs understand what motivates students to pursue sustainable entrepreneurship. This research might improve the well-being of education stakeholders and the community in achieving sustainable development goals.Originality/valueThe study is the first to analyze how sustainable entrepreneurial education and motivation serially mediate the link between a sustainable entrepreneurial environment and aspirations to establish a sustainable business and contribute to the existing literature of SOR from a new perspective.
Toxic marriage – Boeing and McDonnell Douglas
Authors: O’Brien Jamie , Licht John-Gabriel , Pahl Joy M. 
Published: October 2024

Research methodology
Public data such as news reports, interviews and memos were used to craft the case. In addition, the technical reports released by the National Transportation Safety Board (NTSB), along with secondary data in the form of expert accounts and congressional hearings were used to round out the synopsis of the case study.

Case overview/synopsis
This case explores the Boeing–McDonnell Douglas merger and its impact on Boeing’s corporate culture, ethics and strategic decision-making. After the merger, Boeing shifted from a culture focused on engineering excellence to one emphasizing cost-cutting and shareholder value. This cultural shift contributed to the development failures and ethical lapses that resulted in the 737 MAX crisis, which involved two fatal crashes. The case is designed for courses in Strategic Management or Organizational Behavior.

Complexity academic level
Strategic Management or Organizational Behavior
Comparison of efficiency of PFA catheter designs by computer modeling
Authors: Belalcazar Andres , Heist E. Kevin 
Published: October 2024

AbstractIntroductionVarious catheter designs are appearing for Pulsed Field Ablation (PFA). It is unclear if they differ in terms of safety and efficiency. PFA studies have reported hemolysis, kidney injury, high troponin, among other side effects.MethodsUsing a CT‐derived computer model, we compared catheter designs using two metrics: (1) efficiency: power delivered to an atrial wall target, expressed as a percent of total generator power; and (2) safety: electric current to achieve 90% transmurality (since more energy causes more collateral effects), as well as the corresponding electrode current density (ECD), a heat and bubble metric. The following catheter designs were compared: penta‐spline basket, Nitinol spheres (focal 9 mm and large 1‐shot), circular, balloon, and flex‐circuit. Target was a 6 × 47 mm circumferential segment of atrial wall at LPV antrum. Transmurality was defined as percent of target having >600 volts per centimeter (V/cm) electric field needed for electroporation.ResultsEfficiency was 0.9, 1.4, 2.7, 5.9, 10, and 12% for the large 1‐shot and 9 mm Nitinol spheres, penta‐spline, circular, flex spline, and balloon catheters, respectively. Regarding safety, currents for 90% transmurality were 70, 39,36,12.5, 5.3, and 4 Amps for the same respective catheters, with less being safer. ECD was 124, 25, 74, 83, 41, and 31 A/cm2, respectively.ConclusionComputer models demonstrated a remarkable range in efficiency among catheters studied. Those having less atrial blood exposure had the highest efficiencies, with factors of up to 13X more efficiency compared to exposed ones. Higher efficiency designs have less collateral current and are safer. Confirmatory in‐vivo studies are required.
Patient's Perspective on Miniscrews During Orthodontic Treatment—A Systematic Review With Meta‐Analysis
Authors: Vale Francisco , Travassos Raquel , Couto Isabela , Ribeiro Madalena , Marques Filipa , Caramelo Francisco , Marto Carlos Miguel , Spagnuolo Gianrico , Paula Anabela Baptista , Nunes Catarina , Francisco Inês 
Published: October 2024

ABSTRACTDuring orthodontic treatment, undesirable reciprocal forces are generated during tooth movement, which explains the use of anchorage strategies to minimise their harmful effects through intra and/or extraoral appliances. Miniscrews are intraoral devices used for temporary skeletal anchorage. Miniscrews are small‐sized intraoral devices used for temporary skeletal anchorage and are easy to place and remove. However, some studies refer to adverse effects such as inflammation, pain, and discomfort. This systematic review aims to synthesise the available evidence on the use of miniscrews during orthodontic treatment from the patient's perspective. The literature search was conducted using various databases MedLine through PubMed, Cochrane Library, Web of Science Core Collection, and EMBASE. A search was also carried out in the grey literature. The search terms used were “Orthodontic Anchorage Procedures,” “mini‐implant,” “Mini Dental Implant,” “Miniscrew,” and “microimplant.” Cochrane risk of bias tools was used to assess the quality of included studies. Patients tend to overestimate the pain inherent in this procedure. The insertion of micro implants is more accepted than the tooth extraction procedure, with less postoperative pain reported. The location, surgical technique, and type of anaesthesia used in the placement of miniscrews influence levels of discomfort. Additionally, the execution of a good surgical technique and the clinician's communication skills are factors that influence patient satisfaction and positive perception. The most frequent outcome reported is pain and discomfort, which varies depending on its location (less with mini interradicular screws than with extra‐alveolar screws). Most patients are satisfied or very satisfied with this application.
Oral/Perioral Reactions to Injectable Soft Tissue Fillers: A Clinicopathological Multicentric Study
Authors: Pires Fábio Ramoa , Said Aurélio Marcos Tsutyia , Netto Juliana de Noronha Santos , da Cruz Perez Danyel Elias , Bonan Paulo Rogério Ferreti , Martins Helder Domiciano Dantas , Kaminagakura Estela , Alves Fábio de Abreu , Martelli Júnior Hercílio , Machado Renato Assis , Lopes Márcio Ajudarte , Santos‐Silva Alan Roger , Vargas Pablo Agustin , Louredo Brendo Vinicius Rodrigues , Vega‐Memije María Elisa , Cano‐Aguilar Luis Enrique , Toussaint‐Caire Sonia , Monteiro Mariene da Silva , Fonseca Thamyres Campos , Romañach Mário José , Abrahão Aline Correa , Aguirre‐Urizar José Manuel , Lafuente Ibáñez‐de‐Mendoza Irene , Olmedo‐Campos Mireya , Mosqueda‐Taylor Adalberto 
Published: October 2024

ABSTRACTObjectiveTo analyze the characteristics of a series of oral reactions to injectable soft tissue fillers.Materials and MethodsCases diagnosed as oral reactions to injectable soft tissue fillers were selected from eight Pathology laboratories. Information was retrieved from the laboratory charts and from the review of the hematoxylin and eosin‐stained histological slides.ResultsThe 151 patients showed a mean age of 54.9 years, and 136 (90.1%) were females. Mean time of onset was 20.4 months, and the lips were the most frequent location (72.8%). Most cases presented as asymptomatic isolated nodules, with a mean size of 17.4 mm. Silicone (38.5%), polymethylmetacrylate (33%), and hyaluronic acid (11.9%) were the three most common fillers. Granulomas, foamy macrophages, and multinucleated giant cells were observed in 44%, 51.5%, and 65.3% of the cases, respectively. Time of onset was shorter for males (p = 0.033), and symptoms were common in the upper lip, buccal mucosa, and lower vestibule (p = 0.010). Foamy macrophages were more common in association with silicone and collagen (p < 0.001), whereas multinucleated giant cells were more common in association with polymethylmetacrylate, hydroxiapatite, and polylactic acid (p = 0.012).ConclusionClinicians should consider reactions to injectable soft tissue fillers when evaluating asymptomatic submucosal nodules affecting the lips of adult/older females.