bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extreme Precipitation in the West African Cities of Dakar and Ouagadougou: Atmospheric Dynamics and Implications for Flood Risk Assessments
Authors: Engel Thomas , Fink Andreas H. , Knippertz Peter , Pante Gregor , Bliefernicht Jan 
Published: September 2017

Abstract
Two extreme, high-impact events of heavy rainfall and severe floods in West African urban areas (Ouagadougou on 1 September 2009 and Dakar on 26 August 2012) are investigated with respect to their atmospheric causes and statistical return periods. In terms of the synoptic–convective dynamics, the Ouagadougou case is truly extraordinary. A succession of two slow-moving African easterly waves (AEWs) caused record-breaking values of tropospheric moisture. The second AEW, one of the strongest in recent decades, provided the synoptic forcing for the nighttime genesis of mesoscale convective systems (MCSs). Ouagadougou was hit by two MCSs within 6 h, as the strong convergence and rotation in the AEW-related vortex allowed a swift moisture refueling. An AEW was also instrumental in the overnight development of MCSs in the Dakar case, but neither the AEW vortex nor the tropospheric moisture content was as exceptional as in the Ouagadougou case. Tropical Rainfall Measuring Mission (TRMM) 3B42 precipitation data show some promise in estimating centennial return values (RVs) using the “peak over threshold” approach with a generalized Pareto distribution fit, although indications for errors in estimating extreme rainfall over the arid Sahel are found. In contrast, the Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks–Climate Data Record (PERSIANN-CDR) dataset seems less suitable for this purpose despite the longer record. Notably, the Ouagadougou event demonstrates that highly unusual dynamical developments can create extremes well outside of RV estimates from century-long rainfall observations. Future research will investigate whether such developments may become more frequent in a warmer climate.
Perceptions of Corruption: An Empirical Study Controlling for Survey Bias
Authors: Friesenbichler Klaus S. , Selenko Eva , Clarke George 
Published: September 2017

Survey data on corruption are widely used to construct corruption indices, but are hardly questioned. How do individual experiences shape perceptions of corruption? Do more work-engaged respondents perceive corruption as a bigger obstacle to business operations than others? What role does answer bias play in corruption surveys? This article brings together several strands of literature to discuss these questions, and tests them empirically with survey data from Bangladesh and Sri Lanka. We find that individuals who are more work engaged report corruption as a bigger obstacle. So did respondents who were previously exposed to corruption. We control for possible answer bias by implementing a randomized response technique, and find that corruption tends to be under-reported. The effects of work engagement and prior exposure to corruption are more pronounced when the bias indicator is considered, and again become stronger once we control for answer bias affecting past experiences with corruption. JEL: C83, D03, D73, O12
Effect of myofascial techniques for treatment of persistent arm pain after breast cancer treatment: randomized controlled trial
Authors: De Groef An , Van Kampen Marijke , Vervloesem Nele , Dieltjens Evi , Christiaens Marie-Rose , Neven Patrick , Vos Lore , De Vrieze Tessa , Geraerts Inge , Devoogdt Nele 
Published: September 2017

Objective: To investigate the effect of myofascial therapy in addition to a standard physical therapy program for treatment of persistent arm pain after finishing breast cancer treatment. Design: Double-blinded (patient and assessor) randomized controlled trial. Setting: University Hospitals Leuven, Belgium. Patients: A total of 50 patients with persistent arm pain and myofascial dysfunctions after breast cancer treatment. Intervention: Over three months, all patients received a standard physical therapy program. The intervention group received in addition 12 sessions of myofascial therapy, and the control group received 12 sessions of placebo therapy. Main measurements: Main outcome parameters were pain intensity (primary outcome) (maximum visual analogue scale (VAS) (0–100)), prevalence rate of arm pain, pressure hypersensitivity (pressure pain thresholds (kg/cm2) and pain quality (McGill Pain Questionnaire). Measures were taken before and after the intervention and at long term (6 and 12 months follow-up). Results: Patients in the intervention group had a significantly greater decrease in pain intensity compared to the control group (VAS −44/100 vs. −24/100, P = 0.046) with a mean difference in change after three months between groups of 20/100 (95% confidence interval, 0.4 to 39.7). After the intervention, 44% versus 64% of patients still experienced pain in the intervention and control group, respectively ( P = 0.246). No significant differences were found for the other outcomes. Conclusion: Myofascial therapy is an effective physical therapy modality to decrease pain intensity at the arm in breast cancer survivors at three months, but no other benefits at that time were found. There were no long-term effects at 12 months either.
Li (禮), or Ritual Propriety: A Preface to a Confucian Philosophy of Human Action
Authors: Nam Kyung-Hee 
Published: September 2017

AbstractIn this paper, I propose an interpretation of the Confucian concept of li or Ritual Propriety, and suggest a new philosophy of action and mind on the basis of the concept. To achieve this aim, I focus upon and analyze passages in The Analects, and try to establish major Confucian theses on human action. By comparing Confucian views on human action with Western ones, I shed light on the originality of the concept of li.Major theses on li in The Analects are as follows: (1) As an essential characteristic of human behavior, li is ordinary and ubiquitous. (2) Li is a socialized form of our mind, is the outside of an inside, and as such presupposes the unity of the mind and body. (3) Li is a social medium through which we interact with others in order to achieve common values and to turn our society into a harmonious and aesthetic space. To argue for the above theses, I focus on the centrality of language in our life, and utilize Russian psychologist Vygotsky's theory of language learning as well as Wittgenstein's concept of language game, together with the Confucian theory of correct names.
Who Are the Victims and Who Are the Perpetrators in Dating Violence? Sharing the Role of Victim and Perpetrator
Authors: Park Sihyun , Kim Sin-Hyang 
Published: September 2017

Background: Dating violence (DV) is a serious problem with devastating consequences. Often, research on DV has focused on two distinct groups: victims and perpetrators. However, there is growing evidence for a victim–perpetrator overlap model, which posits that those involved in DV are more likely to take on both roles, rather than either role on its own. Purpose: We investigated the patterns of involvement in DV among those who identified themselves as victims or perpetrators in previous studies. Method: This was a systematic review and meta-analysis. A total of 371 variables related to participants’ previous and concurrent experiences of DV victimization or perpetration (202 variables related to victimization and 169 related to perpetration) were identified in 25 studies, which were found by systematically searching three databases: PubMed, Web of Science, and SCOPUS. Results: The majority of previous studies categorized study participants as either DV victims or perpetrators; however, those who identified themselves as either DV victims or DV perpetrators were more likely to assume the opposite role as well. Specifically, current DV perpetrators had a strong association with previous or concurrent victimization experiences, and current DV victims were similarly likely to have assumed the roles of both victim and perpetrator in their histories. Conclusion: Further efforts should be put into avoiding categorization of those involved in violence; rather, they should be regarded as a single group. Additionally, evidence-based interventions should be developed for this population to help break the cycle of violence.
MicroRNAs as biomarkers for clinical studies
Authors: Pogribny Igor P 
Published: September 2017

The development of better diagnostic and prognostic non-invasive biomarkers holds an enormous potential to improve the ability to diagnose and individualize treatment of a great number of human diseases and substantially reduce health care cost. The discovery of a fundamental role of microRNAs in the disease pathogenesis and their presence and stability in biological fluids has led to extensive investigation of the role of microRNAs as potential non-invasive biomarkers for disease diagnosis and prognosis. The result of this research has suggested that alterations of microRNAs may be sensitive indicators of various pathologies; however, despite the indisputable progress in this field, the diagnostic promise of microRNAs has remained a work in progress, and circulating microRNAs have not entered the field of clinical medicine yet. Commonly reported microRNAs as disease biomarkers are largely not disease-specific and the results are often contradicting in independent studies. This review summarizes the current knowledge on the role of microRNAs as disease indicators and emphasizes the current gaps, challenges, and questions that need to be addressed in future well-designed and well-controlled studies for a successful translation of microRNA profiling into clinically meaningful tests. Impact statement This review summarizes the current knowledge on the role of circulating miRNAs as clinical diagnostic biomarkers and highlights the challenges that need to be addressed in future studies for a successful translation of circulating miRNAs into a novel diagnostic tool.
Alterations in circadian and meal-induced gut peptide levels in lean and obese rats
Authors: Moghadam Alexander A , Moran Timothy H , Dailey Megan J 
Published: September 2017

Alterations in gut hormone signaling are a likely contributing factor to the metabolic disturbances associated with overweight/obesity as they coordinate the timing of feeding behavior, absorption, and utilization of nutrients. These hormones are released in response to food intake, or follow a circadian or anticipatory pattern of secretion that is independent of nutrient stimulation. The aim of this study was to identify the degree to which high-fat diet-induced obesity would alter the daily rhythm of gut peptide plasma levels (glucagon-like peptide-1 [GLP-1], peptide YY [PYY], insulin or amylin [AMY]) or meal-induced levels in the middle of the light or dark cycle. Male Sprague-Dawley rats were fed a high-fat diet (OBESE) or chow (LEAN), implanted with jugular catheters, and blood samples were taken every 2 h throughout the light/dark cycle while freely feeding or after an Ensure liquid meal. We found that even when OBESE and LEAN animals ate the same kcals and have a similar pattern of food intake, there is a difference in both the levels and rhythm of plasma gut peptides. GLP-1 and PYY are higher during the light cycle in LEAN animals and AMY is higher in the OBESE group throughout the light/dark cycle. There was also a differential response of plasma gut signals after the Ensure meal, even though the composition and amount of intake of the meal were the same in both groups. These changes occur prior to the high-fat diet induced loss of glycemic control and may be a target for early intervention. Impact statement The aim of this study was to test if obesity would alter the daily rhythm of gut peptides or meal-induced levels in the middle of the light or dark cycle. We found that even when animals are eating the same amount (in kcal) of food that the obese animals have altered daily rhythms and meal-induced gut peptide levels. In particular, we are the first to show that obesity induces increases in peptide YY levels during the light cycle and amylin remains high throughout the light and dark cycle in obese animals. These changes occurred prior to a loss of glycemic control. Thus, the rhythm of gut peptides could be used as an early indicator of later and more serious metabolic disturbances and may be a target for early intervention.
Improving quality and outcomes of stroke care in hospitals: Protocol and statistical analysis plan for the Stroke123 implementation study
Authors: Cadilhac Dominique A , Andrew Nadine E , Kilkenny Monique F , Hill Kelvin , Grabsch Brenda , Lannin Natasha A , Thrift Amanda G , Anderson Craig S , Donnan Geoffrey A , Middleton Sandy , Grimley Rohan 
Published: September 2017

Rationale The effectiveness of clinician-focused interventions to improve stroke care is uncertain. Aims To determine whether an organizational intervention can improve the quality of stroke care over usual care. Sample size estimates To detect an absolute 10% difference in overall performance (composite outcome), a minimum of 21 hospitals and 843 patients per group was determined. Methods and design Before and after controlled design in hospitals in Queensland, Australia. Intervention Externally facilitated program (StrokeLink) using outreach workshops incorporating clinical performance feedback, patient outcomes (survival, quality of life at 90–180 days), local barrier assessments to best practice care, action planning, and ongoing support. Descriptive and multivariable analyses adjusted for patient correlations by hospital (intention-to-treat method). Context Concurrent implementation of financial incentives to increase stroke unit access and use of the Australian Stroke Clinical Registry for performance monitoring. Study outcome(s) Primary outcome: net change in composite score (i.e. total number of process indicators achieved divided by the sum of eligible indicators for each cohort). Secondary outcomes: change in individual indicators, change in composite score comparing hospitals that did or did not develop action plans (per-protocol analysis), impact on 90–180-day health outcomes. Sensitivity analyses: hospital self-rated status, alternate cross-sectional audit data (Stroke Foundation). To account for temporal effects, comparison of Queensland hospital performance relative to other Australian hospitals will also be undertaken. Discussion Twenty-one hospitals were recruited; however, one was unable to participate within the study time frame. Workshops were held between 11 March 2014 and 7 November 2014. Data are ready for analysis.
Risk Factors for Reoperation and Performance-Based Outcomes After Operative Fixation of Foot Fractures in the Professional Athlete: A Cross-Sport Analysis
Authors: Singh Sameer K. , Larkin Kevin E. , Kadakia Anish R. , Hsu Wellington K. 
Published: September 2017

Background: Professional athletes are predisposed to fractures of the foot due to large stresses placed on the lower extremity. These players are concerned with efficiently returning to play at a high level. Return-to-play rates after operative treatment have been previously reported, yet performance outcomes after such treatment are generally unknown in this population. Hypothesis: Overall, professional athletes sustaining a foot fracture would return to play at high rates with little impact on postoperative performance or league participation. However, National Football League (NFL) athletes would have a significantly greater decline in performance due to the high-impact nature of the sport. Study Design: Case series. Level of Evidence: Level 4. Methods: Athletes in the National Basketball League (NBA), NFL, Major League Baseball (MLB), and National Hockey League (NHL) undergoing operative fixation of a foot fracture were identified through a well-established protocol confirmed by multiple sources of the public record. Return-to-play rate and time to return were collected for each sport. League participation and game performance data were collected before and after surgery. Statistical analysis was performed, with significance accepted as P ≤ 0.05. Results: A total of 77 players undergoing 84 procedures met the inclusion criteria. Overall, 98.7% (76/77) of players were able to return to play, with a median time to return across all sports of 137 days. Players returned to preoperative performance levels within 1 season of surgery. Six players (7.8%) sustained refracture requiring reoperation, all of whom were in the NBA. Percentage of games started during the season after primary operative treatment was a predictive factor for reinjury (99% vs 40%, P = 0.001). Conclusion: Athletes returned to play at a high rate after foot fracture fixation, with excellent postoperative performance levels, regardless of sport and fracture location. NBA athletes sustaining fifth metatarsal and navicular fractures are at greater risk of reinjury compared with other athletes. Returning to high levels of athletic participation soon after surgery may predispose athletes to refracture and subsequent reoperation. Clinical Relevance: Players, coaches, and team physicians should be aware of the impact of foot fractures on career performance and longevity to best guide therapy.
Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines
Authors: Middleton Dana M , Li Jonathan Y , Chen Steven D , White Leonard E , Dickson Patricia I , Matthew Ellinwood N , Provenzale James M 
Published: September 2017

Purpose We compared fractional anisotropy and radial diffusivity measurements between pediatric canines affected with mucopolysaccharidosis I and pediatric control canines. We hypothesized that lower fractional anisotropy and higher radial diffusivity values, consistent with dysmyelination, would be present in the mucopolysaccharidosis I cohort. Methods Six canine brains, three affected with mucopolysaccharidosis I and three unaffected, were euthanized at 7 weeks and imaged using a 7T small-animal magnetic resonance imaging system. Average fractional anisotropy and radial diffusivity values were calculated for four white-matter regions based on 100 regions of interest per region per specimen. A 95% confidence interval was calculated for each mean value. Results No difference was seen in fractional anisotropy or radial diffusivity values between mucopolysaccharidosis affected and unaffected brains in any region. In particular, the 95% confidence intervals for mucopolysaccharidosis affected and unaffected canines frequently overlapped for both fractional anisotropy and radial diffusivity measurements. In addition, in some brain regions a large range of fractional anisotropy and radial diffusivity values were seen within the same cohort. Conclusion The fractional anisotropy and radial diffusivity values of white matter did not differ between pediatric mucopolysaccharidosis affected canines and pediatric control canines. Possible explanations include: (a) a lack of white matter tissue differences between mucopolysaccharidosis affected and unaffected brains at early disease stages; (b) diffusion tensor imaging does not detect any existing differences; (c) inflammatory processes such as astrogliosis produce changes that offset the decreased fractional anisotropy values and increased radial diffusivity values that are expected in dysmyelination; and (d) our sample size was insufficient to detect differences. Further studies correlating diffusion tensor imaging findings to histology are warranted.
Extra-axial cerebrospinal fluid spaces in children with benign external hydrocephalus: A case-control study
Authors: Hussain Zaamin B , Hussain Amaani B , Mitchell Patrick 
Published: September 2017

Background The distinction between normal and pathological extra-axial cerebrospinal fluid (CSF) spaces is unclear, with the use of the term benign external hydrocephalus (BEH) not being well defined in clinical practice. This study aimed to establish a distribution of metrics of the subarachnoid space in a population of children diagnosed as normal, and investigate the clinical use of the term BEH. Methods A retrospective case-control study on magnetic resonance image scans was performed on 150 children diagnosed as normal and 10 children diagnosed with BEH. Measurements were taken in the axial plane for CSF width (CSFW), and interhemispheric width (IHW). Results Normal controls had a mean age of 11.1 ± 7.6 months (78 male, 72 female) and the BEH sample had a mean age of 10.6 ± 7.8 months (six male, four female). Mean CSFW was 7.96 ± 4.79 mm in the BEH sample compared to 4.58 ± 2.25 mm in the normal sample ( p < 0.05). Mean IHW was 6.30 ± 2.79 mm in the BEH sample compared to 3.89 ± 1.83 mm in the normal sample ( p < 0.05). However, a substantial overlap between the two distributions of CSFW was found, with 50% of BEH patients lying within a single standard deviation of the mean of normal individuals. Conclusion The absence of diagnostic criteria for BEH means reporting is variable. Patients being diagnosed with BEH who have no other clinical defects may represent the extreme of the normal population rather than a distinct clinical entity.
Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels
Authors: Lavin Michelle , Aguila Sonia , Schneppenheim Sonja , Dalton Niall , Jones Kenneth L. , O’Sullivan Jamie M. , O’Connell Niamh M. , Ryan Kevin , White Barry , Byrne Mary , Rafferty Marie , Doyle Mairead M. , Nolan Margaret , Preston Roger J. S. , Budde Ulrich , James Paula , Di Paola Jorge , O’Donnell James S. 
Published: September 2017

Key Points
Patients registered with low VWF have significant bleeding phenotypes that cannot be explained by concomitant bleeding disorders. Low VWF levels in the range of 30 to 50 IU/dL are predominantly due to reduced VWF synthesis/secretion rather than enhanced clearance.