bluuebunny/crossref_metadata_2025_split huggingface dataset:
ВПЛИВ ПРОБІОТИКА ТА ФІТОБІОТИКА НА КИШКОВИЙ МІКРОБІОЦЕНОЗ ВІДЛУЧЕНИХ ПОРОСЯТ ЗА НЕСПЕЦИФІЧНОГО ГАСТРОЕНТЕРИТУ
Authors: Lukashchuk B.O. , Slivinska L.G. 
Published: October 2016

The article presents results of probiotic TOYOCERIN 109 and phytobiotic EXTRACT™ 6930 influence as part of the basic diet of weaned piglets with nonspecific gastroenteritis in combination with antibiotic (10% enrofloxacin hydrochloride solution) on intestinal microbiocenosis in modern pig farm.Using of probiotic and phytobiotic in combination with antibiotic contributed to disappearance of the major clinical symptoms in pigs of third and fourth experimental groups in 3 days after treatment, whereas in piglets of second experimental group in 5 day .As a result of microbiological studies of weaned piglets feces with nonspecific gastroenteritis we found a change of intestinal microflora.The use of probiotic TOYOCERIN 109 and phytobiotic EXTRACT™ 6930 in combination with antibiotics (10% enrofloxacin hydrochloride solution) for weaned piglets for 5 days helped reduce the number of pathogenic microflora to the level of healthy piglets.Also established a positive effect of probiotic and phytobiotic in combination with antibiotic in normal microflora of gastrointestinal tract, as indicated by normalization of number of the genus Bifidobacterium and Lactobacillus representatives.
МОРФОФУНКЦІОНАЛЬНА ХАРАКТЕРИСТИКА ПЕЧІНКИ ЗА ВИЗНАЧЕННЯ КУМУЛЯТИВНИХ ВЛАСТИВОСТЕЙ ФІТОПРЕПАРАТУ «ЩИТНИК»
Authors: Perig G. 
Published: October 2016

The article presents the results of study of the search influence of the preparation «Shchytnyk» in the form of dry extract got from the roots of masculine ferns (Rhizoma Dryopteris filix–mas, order of many–stems –Polypodiaceae), on the coefficients of the mass of internal organs, some biochemical parameters of blood and morphological structure of rat liver in conditions of cumulation.To determine the cumulative properties of the preparation «Shchytnyk » was used test method «subchronical toxicity» . The experiment was conducted on 18 white rats, 2 – months old, with body mass of 140 – 160g, which were formed into two groups of animals– analogues: I – control, II – research (9 animals in each). To enter a drug it was dissolved in propylene glycol with water in a ratio of 1: 1. Rats of experimental drug were administered orally every day, starting with a dose of 1300 mg/kg (representing 1/10 DL50), followed by increasing doses of 1.5 times every 4 days. The animals from the control group were injected with solvent.The introduction of a new antiparasitis drug to rats «Shchytnyk» for 24 consecutive days at a total dose of 36196,9 mg/kg caused an increase coefficients in liver weight ratios, increased activity of alkaline phosphatase, liver transaminases in serum compared to control, that histologically confirmed dystrophic–necrotic changes in the parenchyma of the liver, and were characterized with the expansion of central venous and intra–lobular capillaries, cariorecsise, grit cytoplasm of hepatocytes.
ЕФЕКТИВНІСТЬ «МАЗІ ДЛЯ РАН» У КОМПЛЕКСНІЙ ТЕРАПІЇ ПРИ ЛІКУВАННІ РВАНИХ РАН ДІЙОК ВИМЕНІ КОРІВ
Authors: Sachuk R.N. 
Published: October 2016

In the study of cows’ mammary glands pathologies it was determined that the udder wounds constitute 1.2% in the overall structure of diseases. The peak of traumatism on cows’ breast wounds falls on summer (pasture–range period) – 77.3%, resulting from offences of sanitary requirements for cattle pasture and grazing. While testing new treatment regimens it was set the high efficiency of «Ointments for wounds» based on essential oils of Siberian Cedar, Eucalyptus, Clove, Cedar, Tea Tree and chlorophyllipt oil solution for treatment of avulsive wounds of cows’ udder teats. It has been proven the reducing of time for treatment compared with traditional drugs «Oxytetracycline Ointment 5%» containing oxytetracycline – a semisynthetic antibiotic of a tetracycline series. Complex therapy, including application of preparation for external use «Ointment for wounds» and hypodermic injection of NSAID «Celecoxib», together with the wound defects closing by sutures with polyglycolide, promotes rapid correction of the clinical condition of cows. It was observed upregulating of hemoglobin by 6.1%, the number of erythrocytes – 11.4%, leukocytes – 9% in the blood, compared with the traditional method of treatment («Oxytetracycline Ointment 5%» and nonsteroidal drug «Kefen»). Local application of phytopreparation «Ointments for wounds» and hypodermic injection of NSAID «Celecoxib» promotes acceleration of inflammatory reactions cancellation in 1,3 times, reduce udder edema – 1.2 times and enhance regenerative processes, thereby reducing treatment time 5 – 6 days compared to control animals.
ТЕЛОМЕРНА ТЕОРІЯ СТАРІННЯ КЛІТИНИ
Authors: Stakhiv O. , Shemediuk N. 
Published: October 2016

Among the row of theories that explain the phenomen on of aging, the large attention of the modern scientific world is turn to ed a side of telomer theory. From this point of view, aging is a result of damage to the genetic apparat. A process is programed and relatedto expression of genes of old «age» on the certain stage of ontogenesis, that are reason destructive changes in a cell. The presence Heynflick`s limit and telomer meter of division of cell sustains this theory. The telomere theory of aging has research of intercommunication of akey moments between the type of cells, presence in a functionally active telomeraza and by stopping of cellular cycle. The telomeraza mechanism of action is building of sequences of nucleotide in the areas of DNA, that is lost with every division of cells. Disruption of the body is a result of the telomere shortening after every cycle of DNA replication. It doesn’t depend on time, but from the amount of replication of DNA and it can be replicometr, that determines the amount of cell divisions. After the achievement critical length of telomeric DNAsegments a cellular cycle is stopped in G1 or G2/M phases. Enzyme contains TERT (telomerase reverse transcriptase), TER (telomerase RNA). An important catalytic domen which inherent reverse transcriptases, domen of joining TER, DNA–substrate, are part of TERT. Onthis time question of searching activators of telomeraza is actual, sciens are interested in it so that number of advanced studies are increase every year.
ДІАГНОСТИКА ХРОНІЧНОЇ СЕРЦЕВОЇ НЕДОСТАТНОСТІ СОБАК – ІСНУЮЧІ МЕТОДИ ТА ПОДАЛЬШІ ПЕРСПЕКТИВИ
Authors: Trofimjak R. , Slivinska L. 
Published: October 2016

The article analyzes the current scientific work related to the study of processes of chronic heart failure (CHF), and the use of biomarkers in the diagnosis of heart disease in dogs. Thoracic radiography, electrocardiography, and echocardiography are used to diagnose heart disease in dogs but despite the use of non–invasive methods, there is uncertainty about the severity of the disease and prognosis for each patient individually. In veterinary practice for the diagnosis of myocardial lesions in animals are clinically valuable, highly sensitive and simple to use cardiac biomarkers. A biomarker is typically a substance in the blood that can be objectively measured and indicates a biologic or pathologic process or response to therapy.1 There are scores of cardiac biomarkers,but this article will focus on the 2 most clinically useful ones in the dog and cat:cardiac troponin I (cTnI) and N–terminal pro–B–type natriuretic peptide (NT–proBNP). The cardiac troponins I, T, and C (cTnI, cTnT, and cTnC) are thin filament–associated regulatory proteins of the heart muscle. Cardiac troponin I («I» for inhibition) is uniquely expressed in the myocardium and is a potent inhibitor of the process of actin–myosin cross–bridge formation. The molecular weight is 24.000 D. Cardiac troponin T («T» for tropomyosin binding) has a molecular weight of 37.000 D and binds the troponin complex to tropomyosin. Cardiac troponin C («C» for calcium) binds to calcium and starts, therefore, the crossbridge cycle. As with cTnI, approximately 95% of cTnT in man and dogs is myofibril bound and about 5% is cytosolically dissolved. Mechanisms for an elevation in circulating cardiac troponins include an increase of myocyte membrane permeability (initial release of the cytosolic troponin pool) or cell necrosis (release of myofibrilbound troponins). Four to six hours after acute myocardial cell injury, the cardiac troponin concentration in blood increases in a biphasic pattern. Plasma half–life of cardiac troponins is approximately two hours, and elimination mainly occurs via the reticuloendothelial system (cTnI and cTnT) and renal loss (cTnT). Cardiac troponins are phylogenetically highly preserved proteins with a more than 95% total structural agreement between mammals. Therefore, established human serologic tests for troponin analysis may be used reliably in pets as well. Myocardial cell injury, manifested anatomically as inflammation (endomyocarditis, myocarditis, perimyocarditis), acute degeneration, apoptosis, or necrosis or hemodynamically as transient or permanent cardiac contractile dysfunction, is a frequent consequence of physical myocardial trauma (cardiac contusion), cardiomyopathy, metabolic or toxic myocardial damage (anthracyclines, catecholamines, bacterial endotoxins, tumor necrosis factor), myocardial ischemia or infarction. However, early diagnosis of myocardial injury may be important from a therapeutic and prognostic perspective.
КОНТРОЛЬ ГЕНЕТИЧНО МОДИФІКОВАНИХ РОСЛИН – ГАРАНТІЯ ПРОДОВОЛЬЧОЇ БЕЗПЕКИ
Authors: Kushnir G.V. 
Published: October 2016

One of the problems in formation of mechanisms of development of environmentally safe environment is the proliferation of genetically modified organisms (GMOs). The use of genetic engineering in agriculture, food and agricultural industry have created the new opportunities for manufacturing the food and feed for meet the ever growing needs of the world's population. However, the opinions of scientists about the benefits and risks of genetic engineering is different. So today is particularly acute issue unpredictable consequences and danger for human health and the environment which are connected with GMO.The article present the results of determination of genetically modified organisms in plant material for the period 2013 – 2015 years, from the farms of different ownership forms. Analysis of the conducted research indicates on the circulation in farms of Lviv region transgenic plants.Found that the most common genetically modified plants were maize, soya and rape. The research of plant material on the presence of GMOs was performed by polymerase chain reaction in real time (PCR RF) by setting in them target sequences of promoter 35S virus of cauliflower mosaic (CaMV), promoter of FMV and (or) terminator NOS (T–NOS) T1 plasmid of Agrobacterium tumefaciens, Pat, EPSPS, Cry 3A, and determined species identification of positive samples. The use of PCR–RF allows quickly and qualitatively detect the GMO in the research samples. In 2013, the percentage of positive samples was 3.9% of the total, in 2014 – 2.3% and in 2015 – 3.3%. It is therefore necessary to monitor the vegetable raw and seed material on the presence of genetically modified organisms, to monitor the situation on GMO in Ukraine, because the problem of biosafety and the evaluation of the potential risks from their use is not studied.
АКТИВНІСТЬ АМІНОТРАНСФЕРАЗ У СИРОВАТЦІ КРОВІ ТЕЛЯТ ЗА ДІЇ ПІРИДОКСИНУ ГІДРОХЛОРИДУ
Authors: Yaremko O.V. , Pelenio R.A. 
Published: October 2016

The influence of pyridoxine hydrochloride (vitamin B6) activity in serum aminotransferases in dairy calves growing period (1 to 90 days). Calves control group received basic diet, but research from the first days of life to the basic diet added pyridoxine hydrochloride doses: I group – 1.0; II – 2.0; III – 3.0; IV – 4.0 V and group – 5.0 mg / kg body weight. Blood for the study was before the morning feeding at 1, 5, 21, 60 and 90 days after birth. Research aminotransferase activity was determined by the content of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and the ratio between them using factor where Ritisa.It was established that the addition of colostrum to milk and pyridoxine hydrochloride leads to increased aminotransferase activity. The low activity of AST and ALT in blood serum of calves of all groups was on the first day of life. Effects of pyridoxine hydrochloride on aminotransferase activity was shown during the research period. Adding to the colostrum vitamin B6 increases the activity of AST by 10 percent or more doses of only 3.0, 4.0 and 5.0 mg/kg body weight. Probably higher AST activity detected in animals II, III, IV and V groups at 21 and 60 days. On the 90th day of the experiment AST activity in serum of calves research groups stabilized, which may indicate the ability of vitamin B6 stimulate the growth and development of microorganisms scar. Adding to the colostrum and milk pyridoxine hydrochloride led to growth within the physiological norm ALT activity. Significant difference between ALT control and experimental groups established in calves III, IV and V groups 21, 60 and 90 day experiment, calves and the second group on day 90 of the experiment. Stabilization of enzyme activity investigated is set to 21 days in calves group IV, 60 – the third group and 90 days in calves second group. The ratio of AST to ALT (coefficient de Ritis) do not go beyond the physiological norm. For correction of vitamin–supply calves 1–21 days old is the optimal dose of daily supplement intake of calves 4 mg / kg body weight of vitamin B6 for calves with 21–60–day age – 3 mg / kg and 60 calves 90–day age – 2 mg / kg body weight.
The Implementation of Patient-Reported Outcome Measures in Yoga Therapy
Authors: Ross Alyson , Birdee Gurjeet , Touchton-Leonard Katharine , Bevans Margaret 
Published: October 2016

Yoga therapists are interested in knowing whether their therapeutic interventions are helpful in improving health and wellbeing in their yoga therapy clients. However, few yoga therapists use standardized, reliable, and valid questionnaires to determine the therapeutic effectiveness of their treatments. Patient-reported outcome (PRO) measures are paper or web-based questionnaires used to assess an individual's perceptions of their symptoms and/or quality of life. In 2004, the National Institutes of Health (NIH) launched the PROMIS® initiative to standardize and simplify the collection of PROs in research and in clinical practice. The PROMIS® initiative launched a multicenter cooperative group that collected and reviewed thousands of PROs, then extensively tested them in over 20,000 research participants. The result was a web-based collection of item banks of the best questions or “items” within three domains of interest: physical, mental, and social health. These item banks are housed in the Assessment Center, a free online resource for collecting PROs.1
Incorporating PROMIS® outcomes into yoga therapy streamlines and optimizes the collection of PROs by enabling access to reliable and valid questionnaires that are easy to read, simple to complete, and are available in multiple languages as well as in both adult and pediatric versions. The use of standardized PROs may improve yoga therapy implementation in healthcare and accelerate translation of clinical research by allowing yoga therapists to conduct indepth symptom assessments using tools that allow for comparisons to other therapeutic clinical and research interventions.
The purpose of this paper is to summarize the development of the NIH PROMIS® initiative and to provide suggestions for incorporating PRO collection into yoga therapy. Important considerations to consider when implementing PROs into yoga therapy are discussed, including the choice of questionnaires and method of delivery (paper or web-based), frequency of PRO administration, interpretation and management of PRO results, and the management of problematic issues that arise.
O papel dos professores/educadores ambientais e seus espaços de formação. Qual é a educação ambiental que nos emancipa?
Authors: Freire Laísa , Figueiredo João , Guimarães Mauro 
Published: October 2016

<p>Neste artigo, sistematizamos as discussões realizadas pelo Grupo de Discussão de Pesquisa - <em>Pesquisa em Educação Ambiental (EA) e a Formação de Educadores(as)-Professores(as)</em>, no VIII EPEA. Partimos de indagações sobre a formação de professores(as) e educadores(as) ambientais em EA e sobre o que significa formar um(a) educador(a) ambiental crítico. Construímos eixos de discussão que permitiram a construção coletiva de reflexões sobre os espaços de formação de professores(as)/educadores(as) ambientais e construção de uma identidade; sobre a legitimação de espaços de formação do(a) educador(a) ambiental na universidade e sobre a formação em pesquisa do(a) educador(a) ambiental. Concluímos que um dos caminhos possíveis é a formação crítica e dialógica, que se propõe a reconhecer o(a) educador(a) ambiental em formação como autor(a) de sua própria formação e de sua trajetória como alguém que elabora seu próprio conhecer na relação com outros seres.</p>
Health Inequalities in Diabetes Mellitus and Hypertension: A Parish Level Study in the Northern Region of Portugal
Authors: Leao Teresa , Perelman Julian , Felício Manuela , Machado Vasco , Lima Graça 
Published: October 2016

Introduction: Diabetes and hypertension are highly prevalent conditions in Portugal. Little is known about the geographical and social patterning of these diseases, which precludes the design of targeted health policies. This study aimed to measure the geographical and socioeconomic distribution of type 2 diabetes and hypertension prevalence in the population resident in the Northern region of Portugal, for the year 2013.Material and Methods: An ecological correlation study analyzed the 2,028 parishes of the region. Prevalence data were obtained from the Regional Health Administration information system. Socioeconomic data were also obtained from this administrative database and from the 2011 national census. The association between each socioeconomic indicator and age-standardized prevalence was measured using the difference in prevalence, population attributable risk, relative inequality index, and regression coefficient.Results: The prevalence of type 2 diabetes and hypertension was 6.16% and 19.35%, respectively, and varied across parishes. These prevalences were significantly associated with low educational level, low tertiary sector weight, unemployment, and low-income rate (with prevalence differences between the most and least advantaged deciles up to 1.3% and 5.3%, respectively). Socioeconomic factors accounted for up to 20% of prevalence.Discussion: This study design did not allow us to evaluate causality and it may underestimate these diseases prevalence or its association with socioeconomic factors, but its results are in line with the evidence from other countries.Conclusion: These results emphasize the socioeconomic and geographical patterning of major diseases associated with a high mortality, and the need of health policies targeting the most deprived parishes.
Cardiopatia Congénita em Crianças com Síndrome de Down: O que Mudou nas Últimas Três Décadas?
Authors: Dias Filipa Mestre A. , Cordeiro Susana , Menezes Isabel , Nogueira Graça , Teixeira Ana , Marques Marta , Abecasis Miguel , Anjos Rui 
Published: October 2016

Introdução: A prevalência da síndrome de Down tem aumentado nos últimos 30 anos; 55% destas crianças apresentam cardiopatia congénita.Material e Métodos: Estudo retrospetivo longitudinal de coorte; dados clínicos obtidos em bases de dados de 1982 a 2013 com o diagnóstico de síndrome de Down ou trissomia 21 num hospital de referência em cardiologia pediátrica e cirurgia cardíaca.Objetivo: Avaliar a evolução, nas últimas três décadas, dos cuidados cardiológicos prestados às crianças com síndrome de Down ecardiopatia congénita.Resultados: Estudámos 102 doentes com síndrome de Down e cardiopatia congénita submetidos a terapêutica invasiva: cirurgiacardíaca corretiva, paliativa e cateterismo terapêutico. Em doentes referenciados no primeiro ano de vida, a referenciação foi cada vez mais precoce. O diagnóstico mais frequente foi o defeito completo do septo aurículo-ventricular (41%). Verificou-se uma tendência para cirurgia corretiva cada vez mais precoce em doentes abaixo dos 12 meses (p < 0,001). A partir de 2000, a grande maioria dos doentes foi operada antes dos seis meses de idade. As principais complicações cardíacas foram alterações de ritmo e baixo débito e as principais não cardíacas foram pulmonares e infeciosas. A taxa de mortalidade a 30 dias foi de 3/102 casos (2,9%). Dos doentes em follow-up, 89% estão em classe funcional I da NYHA.Discussão e Conclusão: A correção cirúrgica mais precoce verificada nos últimos 15 anos vai ao encontro do proposto na literatura. A taxa de mortalidade a 30 dias verificada é sobreponível aos resultados internacionais. Os doentes com síndrome de Down submetidos a cirurgia corretiva de cardiopatia congénita apresentam uma excelente capacidade funcional a longo prazo.
Low Adherence to Mediterranean Diet in Portugal: Pregnant Women Nutrition in Portugal and its Repercussions
Authors: Pereira-da-Silva Luis , Pinto Elisabete 
Published: October 2016

Introduction: Portuguese population is drifting away from the Mediterranean diet-like pattern. In this context, the current nutritionalstatus of women of childbearing age and of pregnant Portuguese women and their growing fetuses is critically reviewed.Material and Methods: A narrative critical review was performed on recent published high quality studies assessing diet and nutritional status of women of childbearing age and pregnant women and its influence on the nutritional status of their offspring.Results: Data from five multinational ecological studies that included Portugal, two national official surveys on food availability, seven national studies on the diet and nutritional status of women of childbearing age and pregnant women, and five national studies on the effect of nutritional maternal factors on their growing fetuses were selected and analyzed. The prevalence of overweight/obesity has dramatically increased in Portuguese women of childbearing age and pregnant women, associated with the described trend of low adherence to Mediterranean diet. Variations in energy and macronutrients intakes during pregnancy seem to have no significantly impact on the nutritional status of growing fetuses. On contrary, pre-pregnancy overweight/obesity has been associated with increased offspring adiposity at birth, and an excessive gestational weight gain may be associated with offspring’s overweight status in childhood. Factors potentially contributing to low adherence to the Mediterranean diet, deserving further investigation, include European Union agriculture policies that have implemented the production of non-Mediterranean food groups at low cost, and insufficient financial capacity to afford foods of quality reported by Portuguese population.Conclusion: Retrieving traditional Mediterranean dietary habits should be incorporated into strategies for prevention and treatment ofoverweight/obesity in Portugal, especially in women of childbearing age.