bluuebunny/crossref_metadata_2025_split huggingface dataset:
Slow brushing reduces heat pain in humans
Authors: Liljencrantz J. , Strigo I. , Ellingsen D.M. , Krämer H.H. , Lundblad L.C. , Nagi S.S. , Leknes S. , Olausson H. 
Published: March 2017

AbstractBackgroundC‐tactile (CT) afferents are unmyelinated low‐threshold mechanoreceptors optimized for signalling affective, gentle touch. In three separate psychophysical experiments, we examined the contribution of CT afferents to pain modulation.MethodsIn total, 44 healthy volunteers experienced heat pain and CT optimal (slow brushing) and CT sub‐optimal (fast brushing or vibration) stimuli. Three different experimental paradigms were used: Concurrent application of heat pain and tactile (slow brushing or vibration) stimulation; Slow brushing, applied for variable duration and intervals, preceding heat pain; Slow versus fast brushing preceding heat pain.ResultsSlow brushing was effective in reducing pain, whereas fast brushing or vibration was not. The reduction in pain was significant not only when the CT optimal touch was applied simultaneously with the painful stimulus but also when the two stimuli were separated in time. For subsequent stimulation, the pain reduction was more pronounced for a shorter time interval between brushing and pain. Likewise, the effect was more robust when pain was preceded by a longer duration of brush stimulation. Strong CT‐related pain reduction was associated with low anxiety and high calmness scores obtained by a state anxiety questionnaire.ConclusionsSlow brushing – optimal for CT activation – is effective in reducing pain from cutaneous heating. The precise mechanisms for the pain relief are as yet unknown but possible mechanisms include inhibition of nociceptive projection neurons at the level of the dorsal horn as well as analgesia through cortical mechanisms.SignificanceSlow brushing stimuli – optimal for activation of C‐tactile fibres – can reduce pain from cutaneous heating. No such effect was seen with fast brushing or vibration. These observations indicate the role of C‐tactile fibres in pain modulation.
A new inherent damping model for inelastic time‐history analyses
Authors: Luco J. Enrique , Lanzi Armando 
Published: March 2017

SummaryThe paper presents a new damping model in which the inherent damping forces during inelastic vibrations are taken to be proportional to the first derivative of the restoring forces with respect to time. The model can also be interpreted as the damping forces being proportional to an estimate of the elastic component of velocity rather than to the total velocity, which includes plastic and elastic components. The model reduces to the conventional viscous damping model for elastic response but differs from it during inelastic deformations. Although the model is based on the initial properties of the structure, the resulting response is similar to that obtained by the conventional viscous approach using current properties (tangent stiffness). The new damping model is evaluated by comparisons with the response for different viscous damping models obtained by numerical inelastic time‐history analyses of a multi‐story structure subjected to different earthquake excitations. Copyright © 2017 John Wiley & Sons, Ltd.
Perception of Peripersonal and Interpersonal Space in Patients with Restrictive‐type Anorexia
Authors: Nandrino Jean‐Louis , Ducro Claire , Iachini Tina , Coello Yann 
Published: March 2017

AbstractThis study examines whether the perception of peripersonal action‐space and interpersonal social‐space is modified in patients with restrictive‐type anorexia in two experimental conditions using videos. First, participants stopped the video of an approaching stimulus when they felt the distance to be comfortable for interacting with it (first‐person perspective). Second, participants stopped the video when an observed individual approaching a stimulus, or being approached by it, was at a comfortable distance (third‐person perspective). In the first‐person perspective, the results showed an estimation of peripersonal space that did not differ from controls when an object was approaching and an increase in interpersonal space compared with controls when a male or female individual was approaching. In the third‐person perspective, both individual‐object and individual–individual distances were larger in anorexic patients. These results indicate a specific deficit in adjusting interpersonal distances in both the first‐person and third‐person perspectives. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Resource allocation, interference management, and mode selection in device‐to‐device communication: A survey
Authors: Ali Sher , Ahmad Ayaz 
Published: March 2017

AbstractFor us to meet the demands of fifth generation technologies, device‐to‐device (D2D) communication is foreseen to be an important part of fifth generation networks. Device‐to‐device communication brings significant improvement in user's throughput, battery life, communication delay, and resource usage. Device‐to‐device links share the same resource with the cellular links that results in interference between cellular users and D2D user equipments. This interference can be managed by suitable resource allocation algorithms. The selection of D2D or cellular communication mode is also a hot research issue. Many research works are available in literature on the aforementioned issues regarding D2D communication, but there is no survey available in the literature. To facilitate the researchers, we present a detailed and systematic survey on resource allocation, interference management, and mode selection in D2D communication in this paper. Initially, the taxonomy based overview of D2D communication is provided, and the classification of the works is outlined. Then, the works regarding mode selection are reviewed in detail. Furthermore, interference management schemes to handle the interference caused by the underlying nature are also surveyed. Then, the available literature on resource allocation schemes in D2D perspective are presented. Finally, some open research problems are identified that deserve further research.
Angiotensin II degrades myeloid cell leukemia 1 in human umbilical vein endothelial cells
Authors: Zhang Wenlong , Yang Ruyan , Feng Yaorong , Hu Bin , Zhang Jun , Zhang Qian , Rong Ningning 
Published: March 2017

AbstractAngiotensin II (Ang II) plays a central role in cardiovascular diseases by causing endothelial apoptosis and dysfunction. Myeloid cell leukemia 1 (Mcl‐1) is an antiapoptotic member of the Bcl‐2 family of apoptosis‐regulating proteins. It has been reported that Mcl‐1 plays a pivotal role in protecting cells against apoptosis. Presently, the effects of Ang II on the expression of Mcl‐1 remain unknown. In this study, we report, for the first time, that the antiapoptotic protein Mcl‐1 is degraded by the proteasome during Ang II‐induced apoptosis in HUVECs. Notably, our results demonstrate that prior phosphorylation by GSK‐3β is required for proteasomal degradation of Mcl‐1. Notably, the reduced level of Mcl‐1 was abolished by a specific GSK‐3β inhibitor, suggesting that the phosphorylation of Mcl‐1 by GSK‐3β is required for proteasomal degradation of Mcl‐1. Overexpression of Mcl‐1 rescued apoptosis induced by Ang II, however, knockdown of Mcl‐1 exacerbated Ang II‐induced apoptosis, thereby indicating that the protein level of Mcl‐1 determines the response of endothelial cells to this drug. © 2017 IUBMB Life, 69(5):321–327, 2017
The effects of presence of a backside screw hole on biotribological behavior of phospholipid polymer‐grafted crosslinked polyethylene
Authors: Watanabe Kenichi , Moro Toru , Kyomoto Masayuki , Saiga Kenichi , Taketomi Shuji , Kadono Yuho , Takatori Yoshio , Tanaka Sakae , Ishihara Kazuhiko 
Published: March 2017

AbstractOne of the important factors in determining the success of joint replacement is the wear performance of polyethylene. Although highly crosslinked polyethylene (CLPE) is presently used, it is still not adequate. We have developed a surface modification technology using poly(2‐methacryloyloxyethyl phosphorylcholine) (PMPC) in an attempt to improve wear performance. In this study, we evaluated the wear and creep deformation resistances of 3‐mm and 6‐mm thick PMPC‐grafted CLPE disks, set on a metal back‐plate, with and without a sham screw hole. The gravimetric wear and volumetric change of the disks were examined using a multidirectional pin‐on‐disk tester. PMPC grafting decreased the gravimetric wear of CLPE regardless of the presence of a screw hole, and did not affect the volumetric change. The volumetric change in the bearing and backside surfaces of the 3‐mm thick disk with a screw hole was much larger than that of those without a screw hole or those of the 6‐mm thick disk, which was caused by creep deformation. PMPC grafting on the bearing surface can be a material engineering approach to reduce the wear without changing the creep deformation resistance, and is a promising surface modification technology that can be used to increase the longevity of various artificial joints. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 610–618, 2018.
Bicomponent ultrashort echo time analysis for assessment of patients with patellar tendinopathy
Authors: Kijowski Richard , Wilson John J. , Liu Fang 
Published: March 2017

PurposeTo compare bicomponent ultrashort echo time (UTE)
parameters of patellar tendon between healthy volunteers and patients with patellar tendinopathy.Materials and MethodsThis study was performed with Institutional Review Board approval and with all subjects signing informed consent. A UTE‐
mapping sequence was performed at 3.0T on the knees of 10 healthy volunteers and in 11 patients with patellar tendinopathy. The UTE‐
relaxation times of the fast relaxing macromolecular bound water component (
) and the slow relaxing bulk water component (
) and the fraction of the fast relaxing macromolecular bound water component (FF) of patellar tendon were measured in all subjects. Wilcoxon rank‐sum tests were used to compare UTE‐
parameters between healthy volunteers and patients with patellar tendinopathy.ResultsMean
,
, and FF of the patellar tendon was 1.5 msec, 23.1 msec, and 79.5%, respectively, for healthy volunteers and 1.9 msec, 22.3 msec, and 75.5%, respectively, for patients with patellar tendinopathy. There were statistically significant differences between groups of subjects for
(P = 0.01) and FF (P = 0.007) but not
(P = 0.10) of the patellar tendon.ConclusionPatients with patellar tendinopathy had significantly higher
and significantly lower FF of patellar tendon than healthy volunteers, which suggests that bicomponent UTE‐
parameters can detect changes in the composition and microstructure of degenerative tendon.Level of Evidence: 1Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2017;46:1441–1447.
Preceding features and relationship with possible affecting factors of persistent and extensive icing events in China
Authors: Wang Zunya , Yang Song , Zhou Botao 
Published: March 2017

ABSTRACTAs two major types of icing, rime and glaze, especially those with long persistency and extensive coverage, cause great economic and social damages for China. Based on 28 persistent and extensive rime events and 19 glaze events in China, this article examined their preceding features and relationship with large‐scale climate factors. The results show that the pronounced preceding signals for these events include the Ural and Okhotsk blocking highs, major East Asian trough, cold air actives, southwesterly moisture transportation and upper‐level jet stream. They intensify greatly 5–7 days ahead, indicating the forthcoming icing events and weaken significantly foretelling the ending of the events.Large‐scale climate factors such as negative phase of the Arctic Oscillation, strong Siberian high, La Niña background and low sea surface temperature from the tropical Indian Ocean to the tropical western Pacific favour the occurrence of glaze events in China by intensifying the East Asian winter monsoon and exciting the southward outbreak of cold airs. In the meantime, deep wintertime semi‐permanent trough in the southern branch of westerlies is crucial for the northward moisture transportation. However, only the low sea surface temperature from the tropical Indian Ocean to the tropical western Pacific and the deep wintertime semi‐permanent trough in the southern branch of westerlies are significantly related to the occurrence of rime events in China. Although weak Australian low and strong western Pacific subtropical high also favour water vapour transportation, they are observed only during a small portion of icing events.
It Is Time to Observe the Creative Process: How to Use a Creative Process Report Diary (CRD)
Authors: Botella Marion , Nelson Julien , Zenasni Franck 
Published: March 2017

AbstractAlthough the first research on the creative process was based on interviews with the aim of identifying the main stages (macro‐process), in the last 50 years researchers have focused more on the analysis of micro‐processes, i.e., the mechanisms underlying the generation of ideas. This interest in the micro‐processes is partly a result of the tools available to researchers to carry out rigorous studies on the creative process. In this article, we present a useful and relevant analytical tool for macro‐processes to assess the creative process in a natural context and when it occurs. Here, the reader will find advice on establishing a research protocol for the creative process by using diaries. Examples of diaries and results are presented. The advantage of this tool is that it enables a direct, rich, and inexpensive assessment of the creative process. Thus, the ecological validity of the diary method is particularly high.
Effect of different forms of selenium on the plant–soil–earthworm system
Authors: Štolfa Ivna , Velki Mirna , Vuković Rosemary , Ečimović Sandra , Katanić Zorana , Lončarić Zdenko 
Published: March 2017

AbstractSelenium (Se) is an essential micronutrient for humans, animals, and certain lower plants, but at higher concentrations Se becomes toxic to organisms. The boundary between the Se beneficial effect and its toxicity is narrow and depends on its chemical form, applied concentration, and other environmentally regulating factors. Due to the potential risk of toxicity in higher concentration, the aim of this study was to estimate the impact of increased concentrations of different forms of Se on the response of the wheat–soil–earthworm system. Soil, earthworms, and wheat grains were exposed to the Se in form of selenite and selenate in concentrations of 0.01, 0.1, and 1 mg kg−1. As an indicator of oxidative stress in wheat, lipid peroxidation levels (LPO) and total H2O2content were determined, while antioxidative response was determined by catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR) activities. The biomarker responses in earthworms were determined by acetylcholinesterase (AChE), carboxylesterase (CES), and antioxidative enzymes (CAT and glutathione S‐transferase) activities. Selenite and selenate increased Se content in the wheat and earthworms, while selenate application was more efficient, indicating higher bioaccumulation of this Se form. Both Se forms did not cause significant changes in the LPO level and H2O2content, while GPX activities were elevated in all treatments, suggesting that oxidative stress was not induced in wheat. In earthworms, Se significantly reduced activities of AChE and CAT at some concentrations, while CES activity was increased at all concentrations applied. This study showed significant impact of Se on measured biochemical responses in wheat and earthworms, indicating the disruption of homeostasis. Obtained results can serve as basis for further studies on Se effects and will help in including different aspects necessary for understanding of Se impact on different components of soil ecosystems.
A core–shell titanium dioxide polyaniline nanocomposite for the needle‐trap extraction of volatile organic compounds in urine samples
Authors: Banihashemi Solmaz , Bagheri Habib 
Published: March 2017

We synthesized a titanium dioxide–polyaniline core–shell nanocomposite and implemented it as an efficient sorbent for the needle‐trap extraction of some volatile organic compounds from urine samples. Polyaniline was synthesized, in the form of the emeraldine base, dissolved in dimethyl acetamide followed by diluting with water at pH 2.8, using the interfacial polymerization method. The TiO2 nanoparticles were encapsulated inside the conducting polymer shell, by adapting the in situ dispersing approach. The surface characteristics of the nanocomposite were investigated by Fourier transform infrared spectrometry, scanning electron microscopy, and transmission electron microscopy. After obtaining acceptable preliminary results, some selected volatile compounds, including chloroform, benzene, toluene, ethylbenzene, xylene, and chlorobenzenes were used as model analytes to validate the enrichment properties of the prepared sorbent in conjunction with gas chromatography mass spectrometric detection. Important parameters influencing the extraction process such as extraction temperature, ionic strength, sampling flow rate, extraction time, desorption temperature, and time were optimized. The limits of detection and limits of quantification values were in the range of 0.5–3 and 2–5 ng/L, respectively, using time‐scheduled selected ion monitoring mode. The relative standard deviation percent with three replicates was in the range of 5–10%. The applicability of the developed needle‐trap method was examined by analyzing urine samples and the relative recovery percentages for the spiked samples were in the range of 81–105%.
Low rank alternating direction method of multipliers reconstruction for MR fingerprinting
Authors: Assländer Jakob , Cloos Martijn A. , Knoll Florian , Sodickson Daniel K. , Hennig Jürgen , Lattanzi Riccardo 
Published: March 2017

PurposeThe proposed reconstruction framework addresses the reconstruction accuracy, noise propagation and computation time for magnetic resonance fingerprinting.MethodsBased on a singular value decomposition of the signal evolution, magnetic resonance fingerprinting is formulated as a low rank (LR) inverse problem in which one image is reconstructed for each singular value under consideration. This LR approximation of the signal evolution reduces the computational burden by reducing the number of Fourier transformations. Also, the LR approximation improves the conditioning of the problem, which is further improved by extending the LR inverse problem to an augmented Lagrangian that is solved by the alternating direction method of multipliers. The root mean square error and the noise propagation are analyzed in simulations. For verification, in vivo examples are provided.ResultsThe proposed LR alternating direction method of multipliers approach shows a reduced root mean square error compared to the original fingerprinting reconstruction, to a LR approximation alone and to an alternating direction method of multipliers approach without a LR approximation. Incorporating sensitivity encoding allows for further artifact reduction.ConclusionThe proposed reconstruction provides robust convergence, reduced computational burden and improved image quality compared to other magnetic resonance fingerprinting reconstruction approaches evaluated in this study. Magn Reson Med 79:83–96, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
One‐step latex compounding method for producing composites of natural rubber/epoxidized natural rubber/aminosilane‐functionalized montmorillonite: enhancement of tensile strength and oil resistance
Authors: Le Duy , Samart Chanatip , Yoosuk Boonyawan , Guan Guoqing , Kongparakul Suwadee 
Published: March 2017

AbstractMontmorillonite (Mt) was intercalated with cetyltrimethylammonium bromide and functionalized with three types of aminosilane (3‐aminopropyltrimethoxysilane, n‐(2‐aminoethyl)‐3‐aminopropyltrimethoxysilane and 3‐[2‐(2‐aminoethylamino)ethylamino]propyltrimethoxysilane). The modified Mt was compounded with natural rubber (NR)/epoxidized natural rubber (ENR) via one‐step latex compounding. The effect of the modified Mt content on the oil resistance and mechanical properties of the NR/ENR/modified Mt composites was investigated. The X‐ray diffraction patterns of the composites showed partial intercalation/exfoliation of the modified Mt in the rubber matrix. Cryogenic fracture and X‐ray fluorescence results revealed highly dispersed modified Mt in the composites in the presence of 10 phr ENR. All three aminosilane groups slightly improved the oil resistance, with the long‐alkyl‐length group producing the greatest improvement. The addition of a small amount of modified Mt improved both oil resistance and tensile strength by increasing in the average diffusion path length in the NR matrix and enhancing the interaction between the modified Mt and the epoxide groups in ENR. The addition of 1.0 phr of modified Mt increased the tensile strength by 18% and decreased the elongation at break by 12% compared with a neat NR/ENR blend. © 2017 Society of Chemical Industry
Use of a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery after kidney transplant
Authors: Williams Kenneth R. , Colangelo Christopher M. , Hou Lin , Chung Lisa , Belcher Justin M. , Abbott Thomas , Hall Isaac E. , Zhao Hongyu , Cantley Lloyd G. , Parikh Chirag R. 
Published: March 2017

PurposeDevelopment of delayed graft function (DGF) following kidney transplant is associated with poor outcomes. An ability to rapidly identify patients with DGF versus those with immediate graft function (IGF) may facilitate the treatment of DGF and the research needed to improve prognosis. The purpose of this study was to use a Targeted Urine Proteome Assay to identify protein biomarkers of delayed recovery from kidney transplant.Experimental designPotential biomarkers were identified using the Targeted Urine Proteome (MRM) Assay to interrogate the relative DGF/IGF levels of expression of 167 proteins in urine taken 12–18 h after kidney implantation from 21 DGF, 15 SGF (slow graft function), and 16 IGF patients. An iterative Random Forest analysis approach evaluated the relative importance of each biomarker, which was then used to identify an optimum biomarker panel that provided the maximum sensitivity and specificity with the least number of biomarkers.Conclusions and clinical relevanceFour proteins were identified that together distinguished DGF with a sensitivity of 77.4%, specificity of 82.6%, and AUC of 0.891. This panel represents an important step toward identifying DGF at an early stage so that more effective treatments can be developed to improve long‐term graft outcomes.
Proteomics: A new perspective for the understanding of pterygia
Authors: Feng Yifan , Yuan Fei 
Published: March 2017

Pterygia is a common ocular surface disease bothering both the patient because of its unsightly appearance and the surgeon because of its tendency to recur. The pathogenesis of pterygia is complex and the exact mechanism(s), especially at the molecular level, remains unknown. The use of modern proteomic techniques such as iTRAQ may yield new knowledge on the underlying pathogenesis of pterygia. In this issue of Proteomics Clinical Applications, Linghu et al. (article number 1600094) identified a total of 156 proteins that expressed differently between the pterygia and healthy conjunctiva using the isobaric tags for relative and absolute quantification based quantitative proteomic analysis. Most significantly, western blotting confirmed that two candidate proteins matrix metalloproteinase 10 (MMP‐10) and CD34 were significantly upregulated in pterygia, suggesting that they have potential roles in the pathogenesis of pterygia. The findings in Linhu's study may provide a new perspective for the understanding of pterygia and develop a new therapeutic target.