bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open innovation and intellectual property: a knowledge-based approach
Authors: Cammarano Antonello , Caputo Mauro , Lamberti Emilia , Michelino Francesca 
Published: May 2017

PurposeThe purpose of this paper is to provide a patent-based framework for investigating the effect of previous and current open innovation (OI) adoption on firms’ knowledge management strategies and type of innovation output.Design/methodology/approachPatent data are employed for gauging innovation practices, exploitation vs exploration strategies, specialization vs diversification choices and type of innovation. The study is performed on a sample of 1,280 patents granted to 66 top R&D spending bio-pharmaceutical companies. The year of analysis is 2010.FindingsThe previous recourse to specific innovation practices influences the current practice selection. R&D collaboration, outsourcing and mergers and acquisitions are employed to pursue exploration. Past purchase of patents increases the likelihood to achieve architectural and radical innovation in current activities.Research limitations/implicationsThe work recommends the use of patent data to gauge many key elements for knowledge and innovation management. Results exhort scholars to investigate innovation practices at the knowledge domain level in order to detect specific behaviors.Practical implicationsThe study provides a methodology for supporting decision-makers in assessing firms’ OI adoption, also performing the benchmark with competitors and R&D partners. Given the high computational effort required for applying the methodology, the authors are planning to give access to the software specifically developed for this study.Originality/valueThe work contributes to the current debate considering the effect of a combination of innovation practices on knowledge management strategies and type of innovation output, with a particular focus on OI activities. Moreover, the separation between the impact of previous and current innovation practices provides useful insights.
Methods, methodology and madness
Authors: Stuart Katharine 
Published: May 2017

Purpose
This paper aims to present findings from a recent study examining current records management as fit for digital government in Australia.

Design/methodology/approach
This paper draws on findings from the first phase of research for a postdoctoral degree. This research was collected through an online quantitative survey of government records management professionals in Australia. The survey’s purpose was to understand whether the profession has kept pace with advances in, and expectations of, digital government. Building on the findings of the survey, this paper explores the concepts of methodology and methods and applies them to current digital records management in the Australian Government. Methodology for Australian Government digital records management is contained in the 2015 Digital Continuity 2020 policy. However, measuring method proved more difficult. The researcher supplemented data published by the National Archives of Australia and the Department of Finance with data from her own research to measure the validity of methods by examining suitability of current requirements.

Findings
Australian Government records management professionals overwhelmingly feel requirements, organisational culture and behaviour form a barrier to implementing successful records management programs. This paper finds that the Australian Government is buying ten times more digital storage per year than the sum of all of the digital Australian Government records known. This suggests perhaps not all records are recognised. While there will always be more storage than records, the ratio should not be so inflated. Further problems are found with requirements for records management being seen as mostly paper-based and too resource intensive to be of use. This research, combined with a contemporary literature review, shows that there is an imbalance with the current methodology and methods and asks the question: Has a methodology (Digital Continuity 2020) been created without suitable and known methods being in place?

Research limitations/implications
The method for collecting survey data was based on self-reporting, which can lead to limitations in that the population sample may exaggerate their response or demonstrate bias. However, responses to the survey were common enough to eliminate bias. The study is based on the Australian Government; however, findings may translate to other governments. This paper presents findings from the first phase of research of a postdoctoral degree. Not all findings are presented, only those relevant to the topic.

Originality/value
As the Australian Government moves to become a true digital government, records management is still required to ensure accountability of government actions and decisions. However, while the government transitions to digital, and information stores continue to grow, the question of whether records management has kept up with the rapid pace of digital information flow and expansion does not need to be asked. Instead, the time has come to ask, “What can we do to keep up?”
Knowledge sharing and organizational change in higher education
Authors: Dee Jay , Leisyte Liudvika 
Published: May 2017

Purpose
Organizational learning in higher education institutions depends upon the ability of managers and academics to maintain a flow of knowledge across the structural boundaries of the university. This paper aims to understand the boundary conditions that foster or impede the flow of knowledge during organizational change at a large public university.

Design/methodology/approach
Interview data were collected from 51 academics and 40 managers at the selected university. The analysis focused on two initiatives that managers sought to implement to improve organizational performance.

Findings
For one of these initiatives, managers engaged in knowledge transformation that enabled managers and academics to learn and collaborate across group boundaries. For the other initiative, managers relied on knowledge transfer practices, which failed to establish productive cross-boundary interactions to support organizational learning.

Practical/implications
When seeking to implement new initiatives to enhance institutional performance, university managers and academics can view organizational change as a learning process that involves creating and moving knowledge across organizational boundaries. Under conditions of change, the creation and movement of knowledge may require the development of new structures and the use of communications that have a high level of media richness.

Originality/value
This study provides one of the first empirical investigations of knowledge sharing dynamics during organizational change in a higher education setting.
Economic Policy with and without Maximizing Rules
Authors: Lipsey Richard G. 
Published: May 2017

AbstractThis paper contrasts the static neoclassical and the evolutionary views of the economy and economic policy. It responds to Ng's comments on Lipsey's original criticism of third‐best theory. Under a relevant definition of informational poverty and Ng's other assumptions, the expected value of any policy‐created divergence from the status quo is negative: If there is not enough known to determine what to do, nothing should be done, rather than establishing first‐best conditions as Ng's analysis has it. It is argued that Ng's analysis of his two other information states adds little to what common sense suggests. To address Ng's argument that policies using context‐specific objective functions lack the required welfare basis, the present paper studies how economic policy is actually pursued absent guides provided by welfare economics. Policies that follow from evolutionary economic theory imply that many things that are seen as ‘distortions’ in welfare economics are actually desirable forces that drive economic growth.
Thermal Treatments for Fruit and Vegetable Juices and Beverages: A Literature Overview
Authors: Petruzzi Leonardo , Campaniello Daniela , Speranza Barbara , Corbo Maria Rosaria , Sinigaglia Milena , Bevilacqua Antonio 
Published: May 2017

AbstractFruit and vegetable juices and beverages are generally preserved by thermal processing, currently being the most cost‐effective means ensuring microbial safety and enzyme deactivation. However, thermal treatments may induce several chemical and physical changes that impair the organoleptic properties and may reduce the content or bioavailability of some nutrients; in most cases, these effects are strongly dependent on the food matrix. Moreover, the efficacy of treatments can also be affected by the complexity of the product and microorganisms. This review covers researches on this topic, with a particular emphasis on products derived from different botanical sources. Technologies presented include conventional and alternative thermal treatments. Advances toward hurdle‐based technology approaches have been also reviewed.
A Ten‐year Study of Suicides from a Rural/Suburban County
Authors: Bready Jennifer C. , Bready Robert J. , Chute Dennis J. 
Published: May 2017

AbstractThis study will discuss trends in suicide data compiled over 10 years in Dutchess County, NY, from 2004 to 2013. These data were based on reporting and examination standards recommended by the National Association of Medical Examiners and Department of Justice death investigation standards. Almost 300 cases were analyzed in terms of the deceased's gender, age, race, method of suicide, and weapon used. Results from this study agree with other reports showing significant differences for method of death both in terms of age and gender, with men more likely to choose firearms and women more likely to choose overdose. Furthermore, older persons were more likely to commit suicide by firearms, and the younger persons were more likely to commit suicide by overdose. However, other areas, such as method of suicide, differ from national statistics.
An overview of the South Korean edible insect food industry: challenges and future pricing/promotion strategies
Authors: Han Rachel , Shin Jungyoung Tiffany , Kim Jin , Choi Yong Seok , Kim Young Wook 
Published: May 2017

AbstractThe purpose of this paper is to provide an overview of the edible insect industry in South Korea and present suggestions for future pricing and promotion strategies. In the first section of this paper, this study outlines the current status and challenges of the edible insect industry in the food market, the material market, the animal feed market, and the medicinal market. The second section of this paper suggests different pricing and promotion strategies for each market segment. This study describes how the consideration of personal traits, information framing, and increasing familiarity can enhance consumer consumption of insect‐based foods.
ratematrix: AnRpackage for studying evolutionary integration among several traits on phylogenetic trees
Authors: Caetano Daniel S. , Harmon Luke J. 
Published: May 2017

AbstractEvolutionary integration occurs when two or more phenotypes evolve in a correlated fashion. Correlated evolution among traits can happen due to genetic constraints, ontogeny, and selection and have an important impact on the trajectory of phenotypic evolution. Phylogenetic trees can be used to study such pattern on macroevolutionary time scales by estimating the strength of evolutionary covariance among traits through time and across clades. However, only few applications implement models to conduct comparative analyses of evolutionary integration.We introduce a Bayesian Markov chain Monte Carlo approach to estimate the evolutionary correlation among two or more traits using the evolutionary rate matrix (R).Ris a covariance matrix that represents both the rates of evolution of each trait and the structure of evolutionary correlation among traits.Here, we present theRpackageratematrix, a resource to test hypotheses of evolutionary integration using multivariate data and phylogenetic trees.ratematrixprovides a flexible framework allowing for any number of evolutionary rate matrix regimes fitted to the same phylogenetic tree and it incorporates the uncertainty associated with parameter estimates, ancestral state reconstruction and phylogenetic estimation in the analyses.Theratematrixpackage uses a novel pruning algorithm that significantly improve computational time. We also provide specific functions that facilitate users to conduct long MCMC analysis when computational resources are limited.
Does early‐life family income influence later dental pain experience? A prospective 14‐year study
Authors: Ghorbani Z , Peres MA , Liu P , Mejia GC , Armfield JM , Peres KG 
Published: May 2017

AbstractBackgroundThe aim of this study was to investigate the association between early‐life family income and dental pain experience from childhood to early adulthood.MethodsData came from a 14‐year prospective study (1991/1992–2005/2006) carried out in South Australia, which included children and adolescents aged 4–17 years (N = 9875) at baseline. The outcome was dental pain experience obtained at baseline, 14 years later in adulthood and at a middle point of time. The main explanatory variable was early‐life family income collected at baseline.ResultsThe prevalence of dental pain was 22.8% at baseline, 19.3% at ‘middle time’ and 39.3% at follow up. The proportion of people classified as ‘poor’ at baseline was 27.7%. Being poor early in life was significantly associated with dental pain at 14‐year follow up (odds ratio = 1.45; 95% confidence interval = 1.27–1.66).ConclusionsEarly‐life relative poverty is associated with more frequent dental pain across the 14‐year follow up and may be a key exposure variable for later dental conditions.
Orbit technique in malrotation with non‐obstructive volvulus: A novel technique of devolvulation
Authors: Kisku Sundeep 
Published: May 2017

AbstractIntroductionVolvulus may be noted in up to two‐thirds of cases involving malrotation beyond infancy. Laparoscopic devolvulation has been described as a frustrating procedure because of restricted visualization. Here, a setup and technique that address these concerns are proposed.Materials and Surgical TechniqueThree boys (median age: 7 years) who had been diagnosed preoperatively with malrotation underwent laparoscopic exploration and devolvulation for volvulus found intraoperatively. The children were placed in a dorsal supine modified lithotomy position. Four 5‐mm ports were inserted—one umbilically, one in the suprapubic region, and one in both the right and left iliac. After the volvulus was inspected, the right iliac atraumatic grasper was placed at the root of the mesentery. The bowel was devolvulated counterclockwise with the grasper used as a pivot—that is, the orbit technique. Once derotated, the rest of the operation proceeded with the division of Ladd's bands, the widening of the mesentery, and appendectomy.DiscussionDevolvulation was successful in all three boys. The orbit technique is a useful devolvulation technique in non‐obstructive volvulus when other techniques fail.
Laparoscopic sigmoidectomy combined with uterus excision for colouterine fistula caused by sigmoid colon diverticulitis: A case report
Authors: Arakawa Satoshi , Morise Zenichi , Isetani Masashi , Tomishige Hirokazu , Kawabe Norihiko , Nagata Hidetoshi , Asano Yukio , Kawase Jin , Kamio Kenshiro , Imaeda Yoshihiro , Umemoto Shunji , Ikeda Masahiro , Horiguchi Akihiko 
Published: May 2017

AbstractA case of colouterine fistula caused by colonic diverticulitis that was successfully treated laparoscopically is presented. A 74‐year‐old woman visited us with lower abdominal discomfort and vaginal excretion with minor fecal contamination. Mild tenderness was observed in her lower abdomen. Blood examinations revealed elevated white blood cell count and C‐reactive protein. Sigmoid colon diverticulitis was revealed on CT, and her condition was diagnosed as colouterine fistula. Hinchey classification was stage I. After 2 weeks of conservative therapy, her symptoms were reduced, and the white blood cell count and C‐reactive protein level decreased. However, fecal contaminated vaginal excretion continued. The patient underwent laparoscopic sigmoidectomy combined with uterus excision, and she has been in good health for the 3 years since the operation. Although colouterine fistula is usually treated with open surgery, patients with controlled and well‐localized inflammation may be good candidates for a laparoscopic approach.
Generation of recombinant bovine interferon tau in the human embryonic kidney cell line and its biological activity
Authors: Takahashi Toru , Sakumoto Ryosuke , Hayashi Ken‐Go , Hosoe Misa , Shirai Junsuke , Hashizume Kazuyoshi 
Published: May 2017

AbstractThe objective of this study was to generate recombinant bovine interferon tau (rbIFNT) in mammalian hosts. The complementary DNA encoding bovine IFNT2 was cloned for the construction of pRcRSV‐bIFNT2 expression vector. The expression vector was transfected to 293 cells. Transfected cells harboring expression vector were selected with G418. Highly expressing clonal line was adapted to serum‐free suspension culture in a spinner flask. The recombinant protein had 24 kDa apparent molecular mass, suggesting being expressed as a glycoprotein, and was purified from serum‐free conditioned medium by the combination of Diethylaminoethanol Sepharose ion exchange and Sephacryl S‐200 HR gel filtration. A total of 7.3 mg rbIFNT was obtained from 13.5 L conditioned medium. Generated rbIFNT was biologically active in terms of antiviral activity measured by the plaque inhibition assay with Madin‐Darby bovine kidney cells and the vesicular stomatitis virus. The recombinant protein was also utilized for immunization to raise antibodies in the rabbit. The generated antibody was capable of use in both Western blotting and the binding assay. The results in the present study suggest that a certain amount of rbIFNT is raised in mammalian hosts by using conventional plasmid vector and its antibody provides useful tools for studies in the biology of bovine IFNT.
Lowland copperhead (Austrelaps superbus) envenomation causing severe neuromuscular paralysis in a dog
Authors: Wright LV , Indrawirawan YH 
Published: May 2017

Case reportA case of lowland copperhead snake (Austrelaps superbus) envenomation in a dog is described. The dog developed severe and prolonged neuromuscular paralysis, including ventilatory failure. The dog was treated successfully with antivenom, intravenous fluids and mechanical ventilation.Clinical significanceThe toxic components of lowland copperhead snake venom are reviewed.
Students’ opinions on welfare and ethics issues for companion animals in Australian and New Zealand veterinary schools
Authors: Degeling C , Fawcett A , Collins T , Hazel S , Johnson J , Lloyd J , Phillips CJC , Stafford K , Tzioumis V , McGreevy P 
Published: May 2017

ObjectiveTo determine what veterinary students in Australia and New Zealand consider important competences in companion animal welfare and ethics (AWE) required on their first day of practice, and to explore how their priorities relate to gender and stage of study.MethodsUndergraduate students at all veterinary schools in Australia and New Zealand were sent an online survey. A subset of questions required participants to rank the importance of preselectedAWEtopics pertaining to companion animals. Data were analysed to determine differences in the way students of different gender or academic stage prioritised each of theseAWEtopics.ResultsOf 3220 currently enrolled students, 851 participated in the survey: 79% were female, 17% male, 4% unspecified. Ranking of theAWEtopics, from highest to lowest importance, was: neutering, companion animal husbandry, euthanasia, behaviour and training, animal breeding, over‐servicing in relation to animal needs and cosmetic surgery. Female students consistently ranked competency inAWEissues surrounding neutering more highly than male students (P = 0.006). Students in senior years of study ranked the importance of competency in animal abuse/hoarding (P = 0.048), shelter medicine (P = 0.012) and animal breeding (P = 0.002) less highly than those in junior years.ConclusionsAustralasian veterinary students placed more importance on competency inAWEissues associated with clinical practice (such as neutering and euthanasia) than on professional behaviours (such as over‐servicing and animal breeding). However, we consider that emphasis should still be placed on developing graduate competency in the latter categories to reflect growing societal concerns about companion animal over‐supply and inappropriate professional conduct.
Radiosensitization by BRAF inhibitors
Authors: Strobel Sophia Boyoung , Pätzold ­Sylvie , Zimmer Lisa , Jensen Alexandra , Enk Alexander , Hassel Jessica Cecile 
Published: May 2017

BackgroundIncreased skin toxicity during combination therapy with a BRAF inhibitor and radiation therapy has recently been reported.Material and MethodsWe present seven melanoma patients with non‐resectable stage III or IV disease and concomitant treatment with a BRAF inhibitor and radiation therapy.ResultsIn all patients, combination therapy yielded a good local response. Only two patients, both on vemurafenib, showed severe radiation dermatitis (CTCAE grade 3/4) after one and two weeks, respectively, resulting in interruption of BRAF inhibitor treatment. The respective cumulative radiation dose was 10 Gy and 35 Gy. The remaining vemurafenib patients displayed only mild radiation dermatitis CTCAE grade 2; the only dabrafenib patient CTCAE grade 1. In one patient, recall dermatitis was diagnosed 14 days after completion of radiation therapy with a cumulative dose of 30 Gy.ConclusionsSevere skin toxicity caused by BRAF inhibitor‐induced radiosensitization is not common and usually amenable to treatment. Thus, combination treatment should remain a therapeutic option, especially in melanoma patients characterized by aggressive tumor growth. Although there is an increased risk of skin toxicity during combination therapy, it is usually well tolerated by most patients. Sequential – instead of simultaneous – treatment does not seem to prevent such toxicity reactions.