bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell Type‐Specific Modulation of Acute Itch Processing in the Anterior Cingulate Cortex
Authors: Li Jiaqi , Bai Yang , Ge Junye , Zhang Yiwen , Zhao Qiuying , Li Dangchao , Guo Baolin , Gao Shasha , Zhu Yuanyuan , Cai Guohong , Wan Xiangdong , Huang Jing , Wu Shengxi 
Published: September 2024

AbstractDespite remarkable progress in understanding the fundamental bases of itching, its cortical mechanisms remain poorly understood. Herein, the causal contributions of defined anterior cingulate cortex (ACC) neuronal populations to acute itch modulation in mice are established. Using cell type‐specific manipulations, the opposing functions of ACC glutamatergic and GABAergic neurons in regulating acute itching are demonstrated. Photometry studies indicated that ACC glutamatergic neurons are activated during scratching induced by both histamine and chloroquine, whereas the activation pattern of GABAergic neurons is complicated by GABAergic subpopulations and acute itch modalities. By combining cell type‐ and projection‐specific techniques, a thalamocortical circuit is further identified from the mediodorsal thalamus driving the itch‐scratching cycle related to histaminergic and non‐histaminergic itching, which is contingent on the activation of postsynaptic parvalbumin‐expressing neurons in the ACC. These findings reveal a cellular and circuit signature of ACC neurons orchestrating behavioral responses to itching and may provide insights into therapies for itch‐related diseases.
Bio‐Inspired Optoelectronic Neuromorphic Device Based on 2D vdW Ferroelectric Heterostructure for Nonlinearly Preprocessing Visual Information and Convolutional Operation
Authors: Guo Feng , Io Weng Fu , Dang Zhaoying , Zhao Yuqian , Pang Sin‐Yi , Zhao Yifei , Lao Xinyue , Hao Jianhua 
Published: September 2024

AbstractThe human visual system provides important inspiration for designing energy‐efficient and sophisticated artificial visual systems. However, integrating nonlinear preprocessing visual information and convolutional operations analogous to those of human in a single device is still in its infancy. In this work, a three‐terminal 2D ferroelectric heterostructure consisting of α‐In2Se3/WSe2 is proposed for designing optoelectronic neuromorphic device. In contrast to conventional ferroelectric materials, the narrow bandgap of the ferroelectric α‐In2Se3 enables the device to perceive visible light directly. Nonlinearly preprocessing is adopted by bipolar cells in the retina and computer algorithms. In the device, similar function is achieved by modulating the energy band based on ferroelectricity. The results demonstrate the ability of the device to suppress noise, and the image recognition accuracy is increased from 75% to 92%. Convolutional neural networks play an important role to extract and compress the image information for human to respond to external environment in real time. Based on the unique coupling of ferroelectricity in α‐In2Se3, the convolutional operation is imitated, thus allowing for reduction in image recognition time by 87%. The results provide a promising strategy to integrate diverse bio‐inspired neuromorphic behaviors in a single device for artificial intelligence to process high‐throughput visual information.
A framework for translating tauopathy therapeutics: Drug discovery to clinical trials
Authors: Feldman Howard H. , Cummings Jeffrey L. , Boxer Adam L. , Staffaroni Adam M. , Knopman David S. , Sukoff Rizzo Stacey J. , Territo Paul R. , Arnold Steven E. , Ballard Clive , Beher Dirk , Boeve Bradley F. , Dacks Penny A. , Diaz Kristophe , Ewen Colin , Fiske Brian , Gonzalez M. Isabel , Harris Glenn A. , Hoffman Beth J. , Martinez Terina N. , McDade Eric , Nisenbaum Laura K. , Palma Jose‐Alberto , Quintana Melanie , Rabinovici Gil D. , Rohrer Jonathan D. , Rosen Howard J. , Troyer Matthew D. , Kim Doo Yeon , Tanzi Rudolph E. , Zetterberg Henrik , Ziogas Nick K. , May Patrick C. , Rommel Amy 
Published: September 2024

AbstractThe tauopathies are defined by pathological tau protein aggregates within a spectrum of clinically heterogeneous neurodegenerative diseases. The primary tauopathies meet the definition of rare diseases in the United States. There is no approved treatment for primary tauopathies. In this context, designing the most efficient development programs to translate promising targets and treatments from preclinical studies to early‐phase clinical trials is vital. In September 2022, the Rainwater Charitable Foundation convened an international expert workshop focused on the translation of tauopathy therapeutics through early‐phase trials. Our report on the workshop recommends a framework for principled drug development and a companion lexicon to facilitate communication focusing on reproducibility and achieving common elements. Topics include the selection of targets, drugs, biomarkers, participants, and study designs. The maturation of pharmacodynamic biomarkers to demonstrate target engagement and surrogate disease biomarkers is a crucial unmet need.Highlights
Experts provided a framework to translate therapeutics (discovery to clinical trials).
Experts focused on the “5 Rights” (target, drug, biomarker, participants, trial).
Current research on frontotemporal degeneration, progressive supranuclear palsy, and corticobasal syndrome therapeutics includes 32 trials (37% on biologics)
Tau therapeutics are being tested in Alzheimer's disease; primary tauopathies have a large unmet need.
Electronic Response and Charge Inversion at Polarized Gold Electrode
Authors: Andersson Linnéa , Sprik Michiel , Hutter Jürg , Zhang Chao 
Published: September 2024

AbstractWe have studied polarized Au(100) and Au(111) electrodes immersed in electrolyte solution by implementing finite‐field methods in density functional theory‐based molecular dynamics simulations. This allows us to directly compute the Helmholtz capacitance of electric double layer by including both electronic and ionic degrees of freedom, and the results turn out to be in excellent agreement with experiments. It is found that the electronic response of Au electrode makes a crucial contribution to the high Helmholtz capacitance and the instantaneous adsorption of Cl can lead to a charge inversion on the anodic polarized Au(100) surface. These findings point out ways to improve popular semi‐classical models for simulating electrified solid–liquid interfaces and to identify the nature of surface charges therein which are difficult to access in experiments.
Hollow Hydrogels for Excellent Aerial Water Collection and Autonomous Release
Authors: Liang Shumin , Al‐Handawi Marieh B. , Chen Tao , Naumov Panče , Zhang Lidong 
Published: September 2024

AbstractAir moisture is a valuable and omnipresent resource of fresh water. However, traditional water collectors come with an enduring problem of the water‐release step, which requires special devices and additional energy to remove the water from the adsorbent, such as heat, sunlight, or both. Herein, we report the first composite conical hollow hydrogel architecture fabricated through a film‐to‐tube transforming protocol, designed to harvest water from aerial humidity. This hollow hydrogel device can rapidly collect water from humid air to a saturation point, whereupon it automatically and continually releases fresh water at room temperature. The entire water collection and release process does not require any external assistance. Therefore, this device is highly suitable for emergency water collection in arid areas. As an exemplary demonstration, positioning the hollow hydrogel device next to a plant turns into an individualized system for irrigation. Since the device is biodegradable, it eventually decomposes and becomes an organic fertilizer after the water supply is not required. For long‐term application, the water‐release process can be monitored in real time by an electronic device to indicate the amount of collected water. The hollow hydrogel combines the humidity‐adsorbing capacity with autonomous water release that carries the potential for harvesting water from humidity to address the shortage of fresh water, especially in arid locations where other sources of water are scarce or inaccessible.
Thermally‐Stable Single‐Site Pd on CeO2 Catalyst for Selective Amination of Phenols to Aromatic Amines without External Hydrogen
Authors: Wang Yaqin , Chen Bingfeng , Li Lina , Mei Xuelei , Gu Yucheng , Wu Haihong , He Mingyuan , Han Buxing 
Published: September 2024

AbstractDeveloping a new route to produce aromatic amines as key chemicals from renewable phenols is a benign alternative to current fossil‐based routes like nitroaromatic hydrogenation, but is challenging because of the high dissociation energy of the Ar−OH bond and difficulty in controlling side reactions. Herein, an aerosolizing‐pyrolysis strategy was developed to prepare high‐density single‐site cationic Pd species immobilized on CeO2 (Pd1/CeO2) with excellent sintering resistance. The obtained Pd1/CeO2 catalysts achieved remarkable selectivity of important aromatic amines (yield up to 76.2 %) in the phenols amination with amines without external hydrogen sources, while Pd nano‐catalysts mainly afforded phenyl‐ring‐saturation products. The excellent catalytic properties of the Pd1/CeO2 are closely related to high‐loading Pd single‐site catalysts with abundant surface defect sites and suitable acid‐base properties. This report provides a sustainable route for producing aromatic amines from renewable feedstocks.
Achieving Controllable Thermochromic Fluorescence via Synergistic Intramolecular Charge Transfer and Molecular Packing
Authors: Feng Weixu , Lu Sumin , Wu Yanhui , Li Xiaotian , Han Dong , Zhao Yan , Tian Wei , Yan Hongxia 
Published: September 2024

AbstractThermochromic fluorescent materials (TFMs) have attracted significant attention due to their unique fluorescent colorimetric response to temperature. However, existing TFMs still suffer from weak stimulus responsiveness, broad temperature response ranges, uncontrollable emission color changes, and low quantum yields. In this study, we address these issues by designing and synthesizing three diketone‐boron complexes with distinct emission wavelengths (NWPU‐(2–4)). Utilizing a molecular engineering strategy to manipulate intramolecular charge transfer transitions and molecular packing modes, our synthesized complexes exhibit efficient fluorescence emission in both solution and solid states. Moreover, their emission wavelengths are highly sensitive to environmental polarity. By incorporating these compounds into thermosensitive matrices of long‐chain alkanes, we produced TFMs with varied fluorescence emission peak variation ranges. Notably, the TFM based on NWPU‐4, owing to its strong charge transfer transitions and dense J‐aggregate packing configuration, not only exhibits intense fluorescence emission spanning the deep red to near‐infrared spectrum but also displays a remarkable 90 nm broad range of thermochromic properties. Ultimately, it was successfully applied to programmable, thermally controlled, multi‐level information encryption.
Cross‐Coupling of Gaseous Alkanes with (Hetero)Aryl Bromides via Dual Nickel/Photoredox Catalysis
Authors: Nair Akshay M. , Martínez‐Balart Pol , Barbeira‐Arán Sergio , Fañanás‐Mastral Martín 
Published: September 2024

AbstractGaseous alkanes represent the most abundant carbon‐based chemical feedstocks in our planet. However, the intrinsic inertness of their C−H bonds has rendered the use of these alkanes very difficult for purposes beyond aerobic combustion and energy intensive processes. Thus, clean and energy‐efficient transformations for their use in synthetic organic chemistry are still rare. Here we report a catalytic methodology for the direct cross‐coupling of gaseous alkanes with (hetero)aryl bromides through the combination of metallaphotoredox‐mediated hydrogen atom transfer and nickel catalysis. This protocol provides an efficient platform for the addition of short alkyl groups into diverse (hetero) aromatic rings, providing a wide range of high‐value alkyl(hetero)arenes, and bypassing the longstanding need of using preactivated alkylating agents in C(sp2)‐C(sp3) cross‐couplings. The method features high chemoselectivity, regioselectivity and a remarkable functional group tolerance, operates under mild conditions, and exhibits operational simplicity
A Magnesium Organic Framework Fluorescent Sensor for Selective Detection of Nitrofuran Antibiotics and Inorganic Pollutants
Authors: Zhao Xiangyu , Yao Xiaoyan , Lv Xueyi , Zhang Xishuo , Sun Hanlei , Wang Hongzhi , Li Yuhan , Yao Shuo , Liu Licheng 
Published: September 2024

ABSTRACTA novel 3D magnesium‐based metal organic framework (Mg‐MOF) has been solvothermally synthesized using 5‐(pyridin‐4‐yl)isophthalic acid. The ligand has demonstrated to preserve two types of coordination modes depending on the connection mode of the pyridine group. The uncoordinated pyridine groups provide Lewis base sites (LBSs), whereas the coordinated ones promote to form a rarely reported eight‐connected tetranuclear Mg clusters. Benefiting from the multinuclearity with high number of connections, the framework keeps good performance of high thermal stability until 500°C. Furthermore, the framework exhibits potential open metal sites (OMSs) benefiting from the terminal coordinated water groups of the metal clusters. Owing to the abundant active sites, the Mg‐MOF exhibits good sensitivity to nitrofuran antibiotics and Cr2O72−, with high KSV (at 104 M−1 level) and low limit of detection (LOD) values (∼10−6 M). Density functional theory (DFT) investigation reveals that the interchange of the HOMO–LUMO energy levels of the framework and antibiotics is responsible for the sensing activity. In addition, the Mg‐MOF is greatly recyclable in five cycles while maintaining the structural rigidity and sensing activity, making it a promising luminescence probe material.
BAD2matrix: Phylogenomic matrix concatenation, indel coding, and more
Authors: Salinas Nelson R. , Eshel Gil , Coruzzi Gloria M. , DeSalle Rob , Tessler Michael , Little Damon P. 
Published: September 2024

AbstractPremiseCommon steps in phylogenomic matrix production include biological sequence concatenation, morphological data concatenation, insertion/deletion (indel) coding, gene content (presence/absence) coding, removing uninformative characters for parsimony analysis, recording with reduced amino acid alphabets, and occupancy filtering. Existing software does not accomplish these tasks on a phylogenomic scale using a single program.Methods and ResultsBAD2matrix is a Python script that performs the above‐mentioned steps in phylogenomic matrix construction for DNA or amino acid sequences as well as morphological data. The script works in UNIX‐like environments (e.g., LINUX, MacOS, Windows Subsystem for LINUX).ConclusionsBAD2matrix helps simplify phylogenomic pipelines and can be downloaded from https://github.com/dpl10/BAD2matrix/tree/master under a GNU General Public License v2.
Customized Nano‐Confinement Effects of Metal‐Organic Frameworks for High‐Performance Lithium‐Sulfur Batteries
Authors: Weng Jingqia , Lu Haibin , Zeng Qinghan , Xiao Yingbo , Yang Junhua , Rong Jionghui , Zhang Qi , Huang Shaoming 
Published: September 2024

AbstractLithium‐sulfur batteries (LSBs) are considered one of the most promising next‐generation energy storage devices due to their significant theoretical energy density and high specific capacity of sulfur cathode. However, several critical challenges still must be addressed for practical application. The shuttle effect and sluggish redox kinetics severely impact their performance. Metal‐organic frameworks (MOFs) have garnered significant interest attributed to their high structural tunability. Their ability to nano‐confine lithium polysulfides (LiPSs) can be precisely controlled at the molecular level by regulating metal centers and organic ligands, thereby suppressing the shuttle effect and improving the electrochemical performance of LSBs. This review summarizes the nano‐confinement effects of MOFs in LSBs, and the discussion is divided into the selective confinement, repulsion, and nano‐confined adsorption by inert MOFs, as well as nano‐confined catalysis facilitated by catalytically active MOFs. Furthermore, the existing challenges and future prospects for application of MOFs in LSBs are proposed.
Pulsed electromagnetic fields attenuate human musculocutaneous nerve damage induced by biceps eccentric contractions
Authors: Kouzaki Karina , Nakazato Koichi 
Published: September 2024

AbstractPulsed electromagnetic field (PEMF) therapy, a noninvasive treatment, has shown promise in mitigating nerve damage. However, unaccustomed exercises, such as eccentric contractions (ECCs), can damage both muscle and nerve tissue. This study investigated whether magnetic stimulation (MS) with PEMF could aid in nerve recovery after ECCs in the elbow flexors. Twenty participants were randomly assigned to either a control (CNT) or an MS group. Following ECCs, we measured the latency of the M‐wave in the musculocutaneous nerve as an indicator of nerve function. Additionally, isometric torque, range of motion, and muscle pain were assessed for muscle function. Interestingly, only the CNT group exhibited a significant increase in latency on Day 2 (p < 0.05). The MS group, on the other hand, displayed an earlier recovery trend in isometric torque, range of motion, and muscle soreness. Notably, muscle soreness significantly decreased immediately after MS treatment compared to pretreatment levels. These findings suggest that MS treatment can effectively attenuate nerve damage induced by ECCs exercise.
Fließfertigung von variablen gekrümmten Modulen für dünnwandige Schalenkonstruktionen aus Beton
Authors: Ivaniuk Egor , Tošić Zlata , Lordick Daniel , Mechtcherine Viktor 
Published: September 2024

AbstractDünne Betonschalen ermöglichen eine erhebliche Materialeinsparung. Die herkömmlichen Herstellungsmethoden von Betonschalen, die auf der Betonage in einer Schalung basieren, sind jedoch aus heutiger Sicht unwirtschaftlich. Der modulare Ansatz kann den Schalenbau deutlich kosteneffizienter machen, insbesondere, wenn Module mit einem hohen Automatisierungsgrad gefertigt werden. Das laufende Projekt „Schalungsfreie Fließfertigung adaptiver Tragstrukturen aus variablen Rahmenelementen – ACDC and beyond“ zielt darauf ab, einen Ansatz für die vollautomatische Herstellung von Betonschalenmodulen mit variabler Geometrie zu entwickeln. Besonderes Augenmerk gilt dabei der Bewehrung der Module, die mittels automatisierter Verlegung von Carbongarnen erfolgt. Die Konturen der Module werden mit hochduktilem Beton (engl.: Strain‐Hardening Cementitious Composite, SHCC) 3D‐gedruckt. Dieser Aufsatz stellt die im Rahmen des Projekts erzielten Ergebnisse vor und gibt einen Überblick über die laufenden Arbeiten, zu denen die Herstellung nicht planarer Module, die Einführung von Nachbearbeitungstechniken und die Verbesserung der Nachhaltigkeit der Technologie gehören.
The efficacy of gemcitabine and docetaxel chemotherapy for the treatment of relapsed and refractory osteosarcoma: A systematic review and pre‐clinical study
Authors: Low Kaan , Foulkes Paola , Hills Frank , Roberts Helen C. , Stordal Britta 
Published: September 2024

AbstractIntroductionOsteosarcoma is the most common primary malignancy of the bone. There is a lack of effective treatments for patients who experience relapsed osteosarcoma. One treatment for relapsed patients is gemcitabine and docetaxel combination chemotherapy (GEMDOX). This systematic review aimed to establish the efficacy of this chemotherapy regimen, as well as identify the common severe toxicities that are associated with it. Resistant osteosarcoma cell lines developed from MG‐63 and HOS‐143B were used to represent relapsed osteosarcoma patients in a pre‐clinical study.ResultsWe identified 11 retrospective and Phase II studies that were suitable for inclusion in our review. 10.65% of patients had a response to gemcitabine and docetaxel combination therapy and the disease control rate was 35% (n = 197). 36%, 35.3% and 18.04% of patients experienced grade 3 or 4 neutropenia, thrombocytopenia and anaemia respectively (n = 133). Male patients (X2 = 9.14, p < 0.05) and those below the age of 18 (X 2 = 10.94, p < 0.05) responded better to GEMDOX treatment than females and patients older than 18 years. The resistant osteosarcoma cell lines remained sensitive to either single‐agent gemcitabine, docetaxel, and the combination of both. Cisplatin‐resistant models (MG‐63/CISR8 & HOS‐143B/CISR8) were the most responsive to GEMDOX treatment compared to doxorubicin, methotrexate, and triple‐combination resistant models.ConclusionGEMDOX treatment has potential efficacy in relapsed osteosarcoma patients especially those with cisplatin resistance. To directly compare the efficacy of GEMDOX therapy against other therapies randomised phase III clinical trials with adequate patient follow up must be performed to improve treatment options for osteosarcoma.
Phytochemical Investigation of an Ostrya carpinifolia L. Extract: An Effective Anti‐Pollution Cosmetic Active Ingredient.
Authors: Trinel Manon , Dubois Camille , Burger Pauline , Plainfossé Hortense , Azoulay Stéphane , Verger‐Dubois Gregory , Fernandez Xavier 
Published: September 2024

AbstractOstrya carpinifolia L., a member of the Betulaceae family, is a tree endemic to the Mediterranean basin that is well known for the hardness of its wood. In this study, we assess the anti‐pollution activities of a hydroalcoholic extract of O. carpinifolia twigs using several judiciously selected in vitro cosmetic bioassays. The extract's capacity to counteract excessive production of reactive oxygen species following a cutaneous exposure to atmospheric pollution was evaluated using a combination of several antioxidant assays: DPPH, FRAP and β‐carotene bleaching assays. These antioxidant assays were complemented by anti‐elastase, anti‐collagenase, anti‐hyaluronidase and anti‐lipoxygenase assays to evaluate the capacity of the extract to preserve the integrity of the skin. The hydroalcoholic extract of O. carpinifolia demonstrates intriguing biological antioxidant activities, with approximately 50 % inhibition observed in DPPH and β‐carotene assays. Furthermore, its anti‐lipoxygenase, anti‐hyaluronidase, and anti‐collagenase activities are noteworthy, exceeding 50 % inhibition. The two major compounds of O. carpinifolia ethanolic extract were isolated and identified as myricitrin (1) and quercitrin (2). Myricitrin and quercitrin exhibit antioxidant and anti‐hyaluronidase properties; we explored the correlation of these properties with the activity of the crude hydroalcoholic extract. Notably, these compounds have not been previously described in the Ostrya genus.