bluuebunny/crossref_metadata_2025_split huggingface dataset:
A dinâmica diferenciadora e o processo de criação na gestão de destinos turísticos
Authors: Sousa Bruno Miguel 
Published: March 2016

É notória a importância do empreendedorismo e da inovação na comunidade académica, assumindo-se como de aplicação global e ligado à criação de riqueza, independência e realização pessoal. Contudo, as interpretações em seu redor continuam fragmentadas, não se verificando uma definição unívoca em torno dos seus conceitos. Sendo o turismo um dos sectores económicos cujo grau de envolvimento é necessário para o seu sucesso, a diversificação de produtos e serviços turísticos torna-se uma exigência capaz de conduzir ao aumento da procura de novos tipos de necessidades em turismo incluindo oportunidades para um turismo mais sustentável. À semelhança de outros sectores emergentes numa economia moderna, o turismo é uma indústria dinâmica e em constante mudança. Desta feita, o empreendedorismo e a inovação assumem-se como fatores críticos no seu desenvolvimento, tanto a nível global como regional. O trabalho de reflexão, aqui proposto, reúne e sistematiza os alguns dos principais aspetos inerentes ao empreendedorismo e processo de criação. Pretende-se, deste modo, proporcionar uma melhor compreensão no que concerne à essência do empreendedorismo e oricessi de criação numa ótica de destinos em turismo. De índole conceptual, o presente estudo pretende evidenciar algumas implicações numa perspetiva turística, bem como apresentado o modelo conceptual da natureza dinâmica do Triggering Process e inovação. Numa perspectiva interdisciplinar, este estudo visa compreender a dinâmica diferenciadora e o processo de criação na gestão de destinos turísticos, propondo a aplicação empírica do modelo conceptual ilustrativo da natureza dinâmica do Triggering Process em contextos específicos de turismo (e.g. turismo de negócios, turismo de natureza, city breaks). Com recurso a modelos de equações estruturais, espera-se que o estudo permita testar a teoria de ordem causal entre o conjunto de variáveis a propor. No final, procede-se a uma reflexão sobre o tema com a explicitação do modelo a aplicar numa ótica de turismo segmentado, discutindo-se linhas de investigação futura.
Cerebellar transcranial magnetic stimulation improves motor function in Parkinson's disease
Authors: Grobe‐Einsler Marcus , Baljasnikowa Viktoria , Faikus Aline , Schaprian Tamara , Kaut Oliver 
Published: September 2024

AbstractObjectiveTo determine whether an accelerated protocol of 48 Hz cerebellar repetitive transcranial magnetic stimulation results in improved motor function in individuals with Parkinson's disease.MethodsIn this double‐blind randomized sham‐controlled study, 35 individuals with Parkinson's disease and stable medical treatment were randomized to either sham or verum transcranial magnetic stimulation. The stimulation was applied bilaterally and medial over the cerebellum and comprised a novel accelerated protocol encompassing two sessions per day on 5 consecutive days. Patients were assessed at baseline, on day 5 after the last stimulation and 1 month post intervention. Measurements included dynamic posturography, UPDRS III, 8‐Meter walk test, and Timed Up and Go test.ResultsThe accelerated protocol was safe and feasible in an outpatient setting. Patients in the verum group showed significant improvement (p < 0.001) of motor symptoms as measured in the UPDRS III. Improvement was mainly carried by the domains rigor, bradykinesia, and gait and persisted after 1 month (p = 0.009), whereas tremor remained unchanged.InterpretationThe effect of a high‐dose transcranial magnetic stimulation in patients with Parkinson's disease is encouraging and comparable to other studies using much longer stimulation protocols. This short‐term intervention of 5 days facilitates the future application in an outpatient setting. Reduction in hospitalization rates directly benefits patients with motor impairment.
Serum glial fibrillary acidic protein predicts disease progression in multiple sclerosis
Authors: Madill Evan , Healy Brian C. , Molazadeh Negar , Polgar‐Turcsanyi Mariann , Glanz Bonnie I. , Weiner Howard L. , Chitnis Tanuja 
Published: September 2024

AbstractObjectiveGlial fibrillary acidic protein (GFAP) is expressed in astrocytes and may be a useful marker of non‐active progressive multiple sclerosis (MS). We evaluate serum GFAP (sGFAP) in a large cohort of MS patients to determine if it predicts progression independent of relapse activity (PIRA), future gait aid, and conversion to secondary progressive disease (SPMS).MethodsAdults with clinically isolated syndrome or any subtype of MS who were listed in the Brigham MS Center Research Database and had at least one sGFAP result were included. All clinic visits following first sample were analyzed for PIRA, future gait aid, and conversion to SPMS. Future cognitive dysfunction and fatigue were evaluated as secondary outcomes.ResultsIn total, 741 patients were included (average age: 42.3, average disease duration: 3.7 years, median EDSS: 2, and median follow‐up duration: 10.0 years). Of 643 patients (86.8%) without progressive disease at baseline, 15.9% developed SPMS. Among all 741, 50.5% had PIRA and 18.6% developed a gait aid requirement. sGFAP level predicted PIRA, future gait aid, and conversion to SPMS in univariable models (p < 0.001, <0.001, and 0.002). sGFAP remained predictive for PIRA and future gait aid in multivariable models in those younger than 50 (p = 0.048, 0.003). Change in sGFAP level over time was not predictive. There was no association between sGFAP and future fatigue or cognitive dysfunction.InterpretationsGFAP helps to predict PIRA, future gait aid, and conversion to SPMS in a large cohort of MS patients. Our data suggest that baseline levels may be more useful than the change over time.
Scalable Equals Sustainable: The Infrastructural Imperative of Earthen Construction
Authors: Feringa Jelle 
Published: September 2024

AbstractBuilding with earth seems a sensible ambition in our troubled climatic times. A fundamental problem, though, is being able to make larger, more complex structures from earth without jettisoning its unique sustainable and artisan qualities at the domestic and sub‐domestic scales. Architecture and robotics specialist and co‐founder of EZCT Architecture & Design Research Jelle Feringa considers the concepts and issues involved.
Concrete Patents: Innovative Building Materials and Construction Processes
Authors: Langenberg Silke , Schlachetzki Sarah M , Rehm Robin 
Published: September 2024

AbstractThe world of patents has always expanded exponentially in line with innovative inventions and materials, and this has been particularly true in the first few decades of the 21st century, which have delivered numerous construction materials and jointing and bonding techniques. ETH Zurich's Silke Langenberg, Sarah M Schlachetzki and Robin Rehm draw attention to the fact that within the academic field of construction heritage, little research has been done to review historical patents for possible sustainable construction materials and methods left by the wayside in the pursuit of industrialised architectural modernism.
Construction of Through‐Space Charge‐Transfer Nanoparticles for Facilely Realizing High‐Performance NIR‐II Cancer Phototheranostics
Authors: Lee Ka‐Wai , Gao Yijian , Chou Shu‐Hua , Wan Yingpeng , Hsu Allen Chu‐Hsiang , Tan Ji‐Hua , Li Yuqing , Guan Zhiqiang , Chen Huan , Li Shengliang , Wong Ken‐Tsung , Lee Chun‐Sing 
Published: September 2024

AbstractPhototheranostics with second near‐infrared (NIR‐II) emissions show great potential for disease diagnosis and imaging‐guided phototherapy owing to deep tissue penetration, high imaging resolution, and excellent tumor eradication. Recently, molecular conjugation engineering and J‐aggregation have been used to construct organic NIR‐II materials. However, these molecules generally have extensive conjugation and large molecular weight in the range of 700–1700 g mol−1, requiring complicated molecular design and synthesis. Herein, a NIR‐II emissive through‐space charge‐transfer (TSCT) nanoparticle (NP) using short‐conjugated donor‐acceptor (D‐A) molecules (TTP) is reported for high‐performance bioimaging and cancer phototheranostics. Owing to the short conjugation of the TTP molecule with a small molecular weight of only 518 g mol−1, the TTP monomer possesses visible absorption and first near‐infrared (NIR‐I) emission. Upon forming NPs in water, the efficient TSCT between TTP monomers leads to significantly red‐shifted absorption to the NIR‐I and emission to the NIR‐II region with a tail that extends to 1400 nm. TTP NPs are employed in NIR‐II in vivo blood‐vessel bioimaging and cancer phototheranostics successfully. This work introduces a facile strategy to construct NIR‐II emissive NPs based on short‐conjugated D‐A molecules for high‐performance biomedical applications.
MoS2/GaN Junction Field‐Effect Transistors with Ultralow Subthreshold Swing and High On/Off Ratio via Thickness Engineering for Logic Inverters
Authors: Zhou Yao , Li Fei , Li Wenfeng , Chen Jianru , Gao Jiahao , Huang Jianming , Zhao Liang , Zhao Tu , Li Jiabin , Zheng Tao , Pan Zhidong , Zheng Zhaoqiang , Huo Nengjie , Luo Dongxiang , Yang Mengmeng , Wang Xingfu , Chen Wenlong , Sun Yiming , Gao Wei 
Published: September 2024

AbstractIn recent years, 2D/3D heterojunction electronic devices have attracted considerable attention. As the size decreases, enhancing the speed of MOSFETs, reducing the subthreshold swing (SS), and lowering the power consumption (P) have become challenging. Therefore, in the post‐Moore era, in response to the continuation of Moore's law, junction field‐effect transistors (JFETs) based on mixed‐dimensional MoS2/GaN heterojunctions are proposed via thickness engineering. Accordingly, flat hetero interface and large potential barrier height of 5 eV across the heterojunction, an ultra‐low SS of 60.9 mV dec−1 (The Boltzmann limit is 60 mV dec−1) is achieved at Vds = 0.1 V when the MoS2 thickness is 10 nm. Additionally, a high Ion/Ioff ratio of 107 and a saturation current density (Jds) of 0.16 µA µm−1 is achieved. As the thickness of MoS2 increased from 6 to 16 nm, the working mode transitioned from enhancement mode to depletion mode. The depletion region across the channel is verified using computer‐aided design technology. Finally, an N‐type load inverter with a maximum voltage gain of 4 and a minimum static P of 25 nW is applied. Overall, the work provides a universal strategy for constructing a series of high‐performance transition metal dichalcogenide/GaN JFETs.
One‐Pot Synthesis of 2,4,6‐Trialkoxy‐ and Triaryloxybenzoates by Cs2CO3‐Mediated Tandem Dimerization/(3+3) Cyclocondensation of 1,3‐Acetonedicarboxylates
Authors: Chang Meng‐Yang , Ho Chin‐Huey 
Published: September 2024

AbstractIn this study, Cs2CO3‐mediated one‐pot tandem dimerization/(3+3) cyclocondensation of 1,3‐acetonedicarboxylates followed by substitution of alkyl or aryl halides was developed to construct functionalized 2,4,6‐trialkoxy‐ and triaryloxybenzoates. In the effective reaction, the core benzene system was formed in a single‐step process under open‐vessel conditions. A plausible mechanism for this reaction is proposed and discussed herein.
Tracking climate vulnerability across spatial distribution and functional traits in Magnolia gentryi in the Peruvian tropical montane cloud forest
Authors: Rodríguez‐Ramírez Ernesto C. , Arroyo Frank , Ames‐Martínez Fressia N. , Andrés‐Hernández Agustina Rosa 
Published: September 2024

AbstractPremiseUnderstanding the responses of functional traits in tree species to climate variability is essential for predicting the future of tropical montane cloud forest (TMCF) tree species, especially in Andean montane environments where fog pockets act as moisture traps.MethodsWe studied the distribution of Magnolia gentryi, measured its spatial arrangement, identified local hotspots, and evaluated the extent to which climate‐related factors are associated with its distribution. We then analyzed the variation in 13 functional traits of M. gentryi and the relationship with climate.ResultsAndean TMCF climatic factors constrain M. gentryi spatial distribution with significant patches or gaps that are associated with high precipitation and mean minimum temperature. The functional traits of M. gentryi are limited by the Andean TMCF climatic factors, resulting in reduced within‐species variation in traits associated with water deficit.ConclusionsThe association between functional traits and climate oscillation is crucial for understanding the growth conditions of relict‐endemic species and is essential for conservation efforts. Forest trait diversity and species composition change because of fluctuations in hydraulic safety‐efficiency gradients.
Digital cognitive assessments as low‐burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer's spectrum
Authors: Vanderlip Casey R. , Stark Craig E. L. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2024

AbstractBACKGROUNDDigital cognitive assessments, particularly those that can be done at home, present as low‐burden biomarkers for participants and patients alike, but their effectiveness in the diagnosis of Alzheimer's disease (AD) or predicting its trajectory is still unclear. Here, we assessed what utility or added value these digital cognitive assessments provide for identifying those at high risk of cognitive decline.METHODSWe analyzed >500 Alzheimer's Disease Neuroimaging Initiative participants who underwent a brief digital cognitive assessment and amyloid beta (Aβ)/tau positron emission tomography scans, examining their ability to distinguish cognitive status and predict cognitive decline.RESULTSPerformance on the digital cognitive assessment was superior to both cortical Aβ and entorhinal tau in detecting mild cognitive impairment and future cognitive decline, with mnemonic discrimination deficits emerging as the most critical measure for predicting decline and future tau accumulation.DISCUSSIONDigital assessments are effective at identifying at‐risk individuals, supporting their utility as low‐burden tools for early AD detection and monitoring.Highlights
Performance on digital cognitive assessments predicts progression to mild cognitive impairment at a higher proficiency compared to amyloid beta and tau.
Deficits in mnemonic discrimination are indicative of future cognitive decline.
Impaired mnemonic discrimination predicts future entorhinal and inferior temporal tau.
Enhancing Anion‐Selective Catalysis for Stable Lithium Metal Pouch Cells through Charge Separated COF Interlayer
Authors: Zhao Peiyu , Zhang Yanhua , Sun Baoyu , Qiao Rui , Li Chao , Hai Pengqi , Wang Yingche , Liu Feng , Song Jiangxuan 
Published: September 2024

AbstractRegulating the composition of solid‐electrolyte‐interphase (SEI) is the key to construct high‐energy density lithium metal batteries. Here we report a selective catalysis anionic decomposition strategy to achieve a lithium fluoride (LiF)‐rich SEI for stable lithium metal batteries. To accomplish this, the tris(4‐aminophenyl) amine‐pyromeletic dianhydride covalent organic frameworks (TP‐COF) was adopted as an interlayer on lithium metal anode. The strong donor‐acceptor unit structure of TP‐COF induces local charge separation, resulting in electron depletion and thus boosting its affinity to FSI−. The strong interaction between TP‐COF and FSI− lowers the lowest unoccupied molecular orbital (LUMO) energy level of FSI−, accelerating the decomposition of FSI− and generating a stable LiF‐rich SEI. This feature facilitates rapid Li+ transfer and suppresses dendritic Li growth. Notably, we demonstrate a 6.5 Ah LiNi0.8Co0.1Mn0.1O2|TP‐COF@Li pouch cell with high energy density (473.4 Wh kg−1) and excellent cycling stability (97.4 %, 95 cycles) under lean electrolyte 1.39 g Ah−1, high areal capacity 5.7 mAh cm−2, and high current density 2.7 mA cm−2. Our selective catalysis strategy opens a promising avenue toward the practical applications of high energy‐density rechargeable batteries.
C60 Fullerene‐Induced Reduction of Metal Ions: Synthesis of C60‐Metal Cluster Heterostructures with High Electrocatalytic Hydrogen‐Evolution Performance
Authors: Yang Wenhao , Huang Qi , Yan Yingying , Li Yaozhou , Xu Tingting , Yu Ao , Zhao Yihang , Peng Ping , Wang Ying , Echegoyen Luis , Li Fang‐Fang 
Published: September 2024

AbstractMetal clusters, due to their small dimensions, contain a high proportion of surface atoms, thus possessing a significantly improved catalytic activity compared with their bulk counterparts and nanoparticles. Defective and modified carbon supports are effective in stabilizing metal clusters, however, the synthesis of isolated metal clusters still requires multiple steps and harsh conditions. Herein, we develop a C60 fullerene‐driven spontaneous metal deposition process, where C60 serves as both a reductant and an anchor, to achieve uniform metal (Rh, Ir, Pt, Pd, Au and Ru) clusters without the need for any defects or functional groups on C60. Density functional theory calculations reveal that C60 possesses multiple strong metal adsorption sites, which favors stable and uniform deposition of metal atoms. In addition, owing to the electron‐withdrawing properties of C60, the electronic structures of metal clusters are effectively regulated, not only optimizing the adsorption behavior of reaction intermediates but also accelerating the kinetics of hydrogen evolution reaction. The synthesized Ru/C60‐300 exhibits remarkable performance for hydrogen evolution in an alkaline condition. This study demonstrates a facile and efficient method for synthesizing effective fullerene‐supported metal cluster catalysts without any pretreatment and additional reducing agent.
Event‐triggered shared control for Euler–Lagrange systems with actuator fault and unknown control direction
Authors: Feng Xiaoying , Zhang Xiaoyu 
Published: September 2024

AbstractSecurity is of paramount importance in the operation of human‐controlled mechanical systems. In the unfortunate event of an accident, the operator may find themselves in a state of distress. This research focuses on the study of adaptive event‐triggered shared control techniques for uncertain Euler–Lagrange systems afflicted by actuator faults and the presence of unknown disturbances. Unlike existing results on shared control, the uncertain Euler–Lagrange system considered in this study contains both an unknown control direction and actuator faults, making it more practical. Furthermore, the controller we have designed demonstrates enhanced stability in the face of these challenges. To counteract the impact of unknown control direction, we introduce a state feedback controller employing Nussbaum functions. Additionally, the devised event‐triggered mechanism serves to reduce the system's network communication resource utilization. The implementation of our shared control strategy ensures asymptotic tracking of target trajectories by the system's outputs while maintaining consistent operation within a defined safe region. Finally, a simulated example is presented to validate the effectiveness of our proposed methodologies.
Near infrared aggregation‐induced emission fluorescent materials for lipid droplets testing and photodynamic therapy
Authors: Wu Jiang , Zhang Yao , Wu Xiaoxiao , Chen Tu , Yan Miao , Shi Shijing , Zhang Fei , Fan Baolei , Zhao Baoqing , Cheng Hong 
Published: September 2024

AbstractNear‐infrared (NIR) fluorescent probes with aggregation‐induced emission (AIE) properties are of great significance in cell imaging and cancer therapy. However, the complexity of its synthesis, poor photostabilities, and expensive raw materials still pose some obstacles to their practical application. This study reported an AIE luminescent material with red emission and its application in in vitro imaging and photodynamic therapy (PDT) study. This material has the characteristics of simple synthesis, large Stokes shift, good photostabilities, and excellent lipid droplets‐specific testing ability. Interestingly, this red‐emitting material can effectively produce reactive oxygen species (ROS) under white light irradiation, further achieving PDT‐mediated killing of cancer cells. In conclusion, this study demonstrates a simple approach to synthesize NIR AIE probes with both imaging and therapeutic effects, providing an ideal architecture for constructing long‐wavelength emission AIE materials.
Exploring eco‐innovation capability and operational performance of energy service companies: Does ownership structure make a difference?
Authors: Munodawafa Russell Tatenda , Johl Satirenjit Kaur 
Published: September 2024

AbstractEco‐innovation capability's enhancement of the operational competitiveness of Energy Service Companies (ESCOs) remains under explored in emerging markets. Furthermore, limited evidence exists on the influence of ownership structure on eco‐innovation capability and operational performance. This study therefore examines the relationship between eco‐innovation capability, ownership structure and operational performance of ESCOs. Questionnaires are electronically distributed to Operations Managers of 287 ESCOs registered by the Energy Commission in Malaysia. To test the direct and moderating effects, Partial Least Square‐Structural Equation Modeling (PLS‐SEM) is applied on 136 valid responses. Results suggest Eco‐innovation Capability significantly enhances ESCOs operational performance, with the model explaining 66% (R2 = 0.656) of the variance. Furthermore, a concentrated ownership structure resulted in higher eco‐innovation capability and operational performance. These results provide pathways for industry practitioners to improve sustainable development contributions and operational performance whilst providing policymakers with a benchmark towards evaluating the effectiveness of the National Energy Policy.
Which social determinants of health have the highest impact in community oncology to advance patient care equity and improve health outcomes? A scoping review
Authors: Majercak Kayleigh R. , Gorman Emily F. , Robert Nicholas J. , Palmer Barbara , Antwi Henry Asante , Mullins C. Daniel 
Published: September 2024

AbstractIntroductionTo better understand the SDOH‐health equity landscape within a community oncology setting to answer the research question, “Which SDOH can have the highest impact in community oncology to advance patient care equity and improve health outcomes?”MethodsArksey and O'Malley's scoping review framework was used to identify evidence related to SDOH and health equity in community oncology. The study was guided by the “10‐Step Framework for Continuous Patient Engagement” and a Community Advisory Board to assure relevance to patients and community providers. Literature was retrieved from literary databases and oncology organizations' websites. Eligible studies included discussion of SDOH and health equity as outlined by the World Health Organization and Centers for Disease Control and Prevention, respectively, and involved community oncology/cancer care in outpatient settings. Studies were excluded if the SDOH‐health equity relationship was not discussed.ResultsThe review resulted in 61 exploratory and 17 confirmatory “intervention” studies addressing the impact of SDOH on health equity in community oncology settings. The most frequently SDOH‐health equity pairs identified were the SDOH categories, social inclusion and non‐discrimination, income and social protection, and structural conflict, all paired with the health equity category, access to care/treatment. Confirmatory studies focused on income and social protection (SDOH) and access to care/treatment (health equity); the SDOH categories, social inclusion and non‐discrimination and health/general literacy–patient, paired with the health equity category, and adherence/compliance.ConclusionsLiterature highlights the SDOH and health equity relationship within the realm of oncology. Most studies on SDOH/health inequities in the community oncology setting are exploratory. There is the need to shift from documentation of cancer inequities to implementing solutions.