bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technique of functional simulation as a tool for providing the required quality of fortified bakery products
Authors: Tretyak L. N. , Rebezov M. B. , Yavkina D. I. 
Published: October 2024

Relevance. The problem of irrational and unbalanced nutrition is relevant for almost all regions of Russia. There is a need to enrich everyday products with micronutrients that are of particular importance in the diet. Fortified bread and bakery products with specified consumer properties in the diet can be one of such valuable products.Methods. The methodology of structural analysis and design of systems (Structured Analysis and Design Technique, SADT) is often used in life cycle management of complex high-tech products and has not found wide application in the food industry. The authors substantiate the need to introduce tools for functional and graphical modeling of business processes that implement the SADT methodology in life cycle management to ensure the quality of finished bakery products.Results. An original generalized functional and logical model of the process “To produce enriched bread (bakery products) with regionally significant micronutrients” has been developed. The analysis of the technology of enriched bakery products, carried out at various levels of decomposition of the process, revealed that the quality of the finished product is significantly influenced by the choice of the technological stage of applying the components of the mixture proposed for the enriching composition. It has been established that preference should be given to organic forms of additives — components of the enriching composition. To preserve the nutritional properties of bakery products, an enriching composition is proposed to be applied to the surface of the finished product. The proposed method has been tested in experimental production conditions. Its manufacturability and controllability of the proposed technical solutions are proved. The approach to functional and graphical modeling of food technologies developed by the authors on the example of bakery products opens up prospects for improving the quality of finished products and can be widely used in food engineering.
Reducing the danger of phytopathogen toxins by using an organomineral composition
Authors: Valiullin L. R. , Mukhammadiev R. S. , Samsonov A. I. , Yarullin A. I. , Mingaleev D. N. , Zueva J. V. , Sevostyanov M. A. , Baryshev M. G. , Yezhkova A. M. 
Published: October 2024

Relevance. Contamination by toxins of phytopathogens or mycotoxins of food and feed raw materials of plant origin poses a serious threat to the production of high-quality and safe agricultural products. Reducing the risks of contamination of plant raw materials with mycotoxins depends on the effective use of biological products to reduce the toxicity of mycotoxins.Methods. Experiments were carried out on primary rat liver cells. Primary liver cells were cultured in DMEM medium in the presence of 10% fetal calf serum at 37OC and 5% CO2. Zearalenone and T-2 toxin were dissolved in a mixture of DMSO and 96% alcohol in a ratio 1:1. Zearalenone T-2 toxin and protective compositions were mixed and aged together for 6 hours and after exposure added to a medium with a cellular monolayer. The concentration of bacterial-based compositions KMBI-3 and KMCI-3 was used for research in three variants: 0.4 mg/ml, 2 mg/ml, 4 mg/ml. After 24 hours of cultivation, the cell layer was evaluated using an inverted microscope according to the following parameters: percentage of surface coverage, cell shape, number of cell aggregates, number of floating cells.Results. A dose-dependent decrease in cell viability was revealed when exposed to zearalenone and T-2 toxin, the most toxic effect was observed at doses from 0.5 х 10-4 and 8.6 х 10-8 M and 2.14 х 10-7 M, respectively. When using the protective composition KMBI-3 at a dose of 4 mg/ml, the least negative effect of zearalenone and T-2 toxin on cell culture was observed. The use of compositions of organomineral origin KMBI-3 helps to increase cell viability when exposed to the toxins zearalenone and T-2 toxin, which indicates the activation of proliferative processes in comparison with the group without the use of drugs. The use of the biopreparation KMBI-3 reduces the pathogenic effect of zearalenone and T-2 toxin on cell culture, increases the resistance of liver cells to the effects of phytopathogen toxins.
Preserving of the bovine chilled semen viability
Authors: Nikitkina E. V. , Pleshanov N. V. , Bogdanova S. S. , Turlova J. G. 
Published: October 2024

The aim of the work is to assess the biological usefulness of bull semen when cooled to 5 °C and stored for a period of time.Sperm cooling is less traumatic for cells than deep freezing. The fertilizing capacity of chilled sperm is higher than cryopreserved sperm, but it persists for several days, which limits its use. The study was conducted using native sperm from black-and-white (n = 6) and Ayrshire bulls (n = 3). Two diluents were used in the experiment: OptiXcell commercial diluent (IMV) (France) was used as a control, and an experimental diluent based on Tris was developed as an experiment. There was no significant difference in overall and progressive mobility between the studied diluents. In most cases, the spermatozoa were alive for 10 days. If we take into account the progressive mobility of 40% as the minimum permissible for artificial insemination, on average, the studied bulls had it during storage for 120 hours. At the same time, there were individual ejaculates that had progressive mobility (40% and higher) even after 168 hours of storage. There were no significant differences in membrane safety when diluted with the studied diluents. When stored for 72 hours, there was practically no decrease in the number of intact cells when using an experimental diluent. The preparation and application of an experimental diluent are economically more profitable than using a Western analogue — OptiXcell (IMV). At the same time, the diluent developed by the authors is not inferior in characteristics (qualitative indicators of spermatozoa), and even surpasses the foreign one.
Updating information of mycoses and antifungal medicines to find effective platforms for the production of new thiazole compounds
Authors: Chernykh T. F. , Bogdanova O. Yu. , Flisyuk E. V. , Kozur Yu. M. , Sidorov K. O. , Narkevich I. A. 
Published: October 2024

Introduction. Information about mycoses and antifungal drugs of the modern type is often fragmentary and unsystematic, which requires correction.Aim. To systematize the latest information about fungi and mycoses, means of combating them and the problems encountered along the way, to highlight the latest achievements in the field of synthesis and research of the activities of 1,2,4-triazole as a potential fungicidal compound.Materials and methods. The materials were the authors' research published in advanced scientific journals, conducted around the world in the field of studying fungi, antifungal drugs, and the search for new antifungal agents.Results and discussion. The article provides an overview of current information on the morphobiological features of fungi, updating their taxonomy and nomenclature, shows the role of fungi in nature and the development of fungal infections in humans and animals, structured information on the classification of mycoses and their pathogens. The latest information is also provided on the pharmacological properties of the main currently existing antifungal drugs, the mechanisms of formation of resistance to them in fungi, in a comparative aspect with other groups of antimycotic drugs, the prospects of azoles and their derivatives as new fungicidal drugs and disinfectants are shown. Literature studies have shown that 1,2,4-triazole derivatives have a wide range of antifungal activity, which extends to other types of activity.Conclusion. It was noted that the significant prospects of triazoles are due, among other things, to the fungicidal effect on resistant strains of fungi-pathogens of human and animal infections. The advantage of the new derivatives is the low level of concentrations suppressing fungi, low cytotoxicity, which allows them to be used for intravenous administration in the future. Updating information on the effectiveness of new antifungal compounds will help researchers systematize knowledge about the properties of azoles, which can contribute to the search and development of new potential candidates for antifungal drugs with high efficiency and selectivity, and contribute to the formation of new research directions for the search for effective means of combating mycoses in various fields of human activity.
FUKUGOUGO DI PABRIK PENGOLAHAN MAKANAN FRESHCENTER SHOKUBUN (KAJIAN MORFOSEMANTIK)
Authors: Fauzah Nunik Nur Rahmi , Hidayati Yanti , Ulfiyah Evi 
Published: October 2024

Abstrak: Dalam percakapan yang digunakan didalam lingkungan kerja pabrik pengolahan makanan ditemukan kosakata yang dibentuk melalui proses penggabungan atau fukugougo. Tujuan penelitian untuk menganalisis variasi jenis fukugougo dan makna fukugougo yang ada di pabrik pengolahan makanan Freshcenter Shokubun. Teori yang digunakan merupakan teori dari Shibatani. Sumber data merupakan percakapan yang dilakukan para pegawai pabrik dilingkungan kerja dengan data berupa fukugougo yang ditemukan didalam percakapan tersebut. Metode yang digunakan yaitu metode deskriptif kualitatif dengan teknik pengumpulan data berupa teknik libat catat. Dari penelitian ini ditemukan 9 data teridentifikasi sebagai fukugougo, 4 data merupakan native compound, 1 data berupa sino japanese compound, dan 2 data merupakan hybrid compound. Dari segi makna, ditemukan 4 fukugougo maknanya berasal dari 2 kata pembentuknya, 2 fukugougo maknanya hanya berasal dari salah satu kata pembentuknya saja, dan 1 fukugougo makna katanya tidak terbentuk dari salah satu kata pembentuknya.
Kata Kunci: fukugougo, morfosemantik, pengolahan makanan, kata majemuk
Phenomenal Eros: For a History of Sensuality
Authors: Sissa Giulia 
Published: October 2024

Forty years of scholarship in the history of sexuality and gender studies have delivered a considerable amount of knowledge, framed by an encompassing premise: power is paramount. A preferred object of this kind of attention are the erotic cultures of ancient Greece and Rome. The focus on power leads contemporary scholars to adopt binary thinking, namely the attribution to ancient writers and thinkers of dichotomies such as domination versus subjection, or activity versus passivity. This is a fixist view that obliterates the dialectic of desire and, therefore, its fundamental mobility. Desire aims at the other person’s desire; roles are exchanged; age and social status can play in surprising ways; hyperactivity can become subjugation. It is time for a change. It is time to look at what mattered for the Ancients themselves: the subjective experience of sensations, bodies and situations; the felicitous, ironic, or tragic reversals of intersubjective games. More importantly: the quest for pleasure, rather than the use of pleasures. The Greeks thought the sexual experience as sensuality. And sensuality inflects what they thought about gender. In poetry, narrations and philosophy, concrete details draw our attention to the felt phenomena of lived bodies – in the plural. When we look for the logic of gender, we discover that bodies can be compared, not as totalities, but as bundles of multiple discreet qualities, ready to be combined and recombined, allotted and exchanged. Qualities can be bits and pieces of anatomy, manners and garments; but also fragments of experience, moments of sensory awareness. The logic of the concrete meets the phenomenal body. For the body is a challenge, to be taken up – as a cinematic life, frame after frame. Sensations can be shared across the boundaries of female and male, which are adjectives, not substances. A granular, corpuscular, pointilliste redistribution of traits, distinctive – or not. Sensuality is queer. Like Plato’s pharmacy, erotic materialism can deliver us, beautifully, cathartically, refreshingly from the modern strictures of binary thinking. This is what the Greeks have to tell us. Let us listen!
Representation, Settler Colonialism and ‘the Aboriginal Child’: a Politics of Subalternity?
Authors: Faulkner Joanne 
Published: October 2024

Gayatri Chakravorty Spivak famously thematised the question ‘can the subaltern speak?’ through the dual meanings of ‘representation,’ as both depiction and political proxy. This paper draws on Spivak’s analysis to question the capacity of the settler-colonial Australian imagination to represent (or recognise) the sovereignty of Aboriginal peoples – and especially of children, as infants (in-fans, literally speechless). The former sense of representation (depiction) bears implications for the second, as Indigenous sovereignty is displaced by settler representations of indigeneity – and particularly of Indigenous ‘childhood’ and ‘children’ as neglected ‘piccaninnies,’ without parentage or inheritance. Such portrayals, in this light, may even be read as continuous with colonial logics of elimination, as strategies to sever the connection to land that undergirds Indigenous conceptions of sovereignty and to thwart Indigenous futures. The article interrogates settler colonial investments in representing Aboriginal childhood in the context of recent public discourse about the constitutional recognition of First Peoples, and a political imperative to re-present the Australian ‘nation’ as post- (rather than currently) colonial. The questions that animate this inquiry include: what, if anything, can a settler-Australian politics of recognition offer First Peoples? Is it possible to represent (or recognise) Blak sovereignty through modifications to the settler constitution? And how does the settler image repertoire of Aboriginal children speak to this possibility? If that fabricated ‘Aboriginal child’ could speak, what would this ultimate ‘subaltern’ say?
Bioprocess feeding optimization through in silico dynamic experiments and hybrid digital models—a proof of concept
Authors: Barberi Gianmarco , Giacopuzzi Christian , Facco Pierantonio 
Published: October 2024

The development of cell cultures to produce monoclonal antibodies is a multi-step, time-consuming, and labor-intensive procedure which usually lasts several years and requires heavy investment by biopharmaceutical companies. One key aspect of process optimization is improving the feeding strategy. This step is typically performed though design of experiments (DoE) during process development, in such a way as to identify the optimal combinations of factors which maximize the productivity of the cell cultures. However, DoE is not suitable for time-varying factor profiles because it requires a large number of experimental runs which can last several weeks and cost tens of thousands of dollars. We here suggest a methodology to optimize the feeding schedule of mammalian cell cultures by virtualizing part of the experimental campaign on a hybrid digital model of the process to accelerate experimentation and reduce experimental burden. The proposed methodology couples design of dynamic experiments (DoDE) with a hybrid semi-parametric digital model. In particular, DoDE is used to design optimal experiments with time-varying factor profiles, whose experimental data are then utilized to train the hybrid model. This will identify the optimal time profiles of glucose and glutamine for maximizing the antibody titer in the culture despite the limited number of experiments performed on the process. As a proof-of-concept, the proposed methodology is applied on a simulated process to produce monoclonal antibodies at a 1-L shake flask scale, and the results are compared with an experimental campaign based on DoDE and response surface modeling. The hybrid digital model requires an extremely limited number of experiments (nine) to be accurately trained, resulting in a promising solution for performing in silico experimental campaigns. The proposed optimization strategy provides a 34.9% increase in the antibody titer with respect to the training data and a 2.8% higher antibody titer than the optimal results of two DoDE-based experimental campaigns comprising different numbers of experiments (i.e., 9 and 31), achieving a high antibody titer (3,222.8 mg/L) —very close to the real process optimum (3,228.8 mg/L).
A novel taxonomy for facilitating in-depth comparison of continuing engineering education practices
Authors: Caratozzolo Patricia , Smith Christopher J. M. , Gomez Sonia , Moris Matías Urenda , Nørgaard Bente , Heiß Hans-Ulrich , Azofeifa Jose Daniel 
Published: October 2024

IntroductionThis study addresses the urgent need for standardized frameworks in Continuing Engineering Education (CEE) to support lifelong learning in the rapidly evolving global workforce. Significant events, such as the Digital Transformation and the rise of artificial intelligence, have highlighted the demand for adaptable and diverse learning systems, especially in engineering education. On the one hand, the World Economic Forum's, 2023 Future of Jobs Report predicts a transformation in 44% of workers’ core skills within 5 years, with engineering facing substantial labor shortages. On the other hand, the Paris Agreement’s call for sustainable development necessitates a workforce with skills aligned with the green transition.MethodsThe research introduces an innovative framework taxonomy that categorizes and organizes CEE programs by integrating standardized terminologies. It focuses on critical elements such as resourcing, organizational models, and program development strategies to provide a comprehensive structure that supports consistency and comparability across diverse educational contexts.ResultsUnlike existing models, the proposed framework enhances cross-institutional learning and dissemination of best practices. It identifies key components required for effective CEE management, filling a critical gap in the literature. The study’s output is a taxonomy for discussing and comparing CEE institutional approaches and practices to advance the field and foster a global CEE community committed to excellence in engineering education.DiscussionsThis study equips educators, policymakers, and industry leaders with a practical tool to design, implement, and scale CEE programs. It ultimately fosters a skilled workforce prepared to meet the challenges of future technological and sustainable transitions, supporting the development of a standardized approach to CEE.
Toward promoting resilience of gender and sexually diverse youth in South African rural school ecologies
Authors: Zhange Mthandeki , Mohangi Kamleshie 
Published: October 2024

IntroductionGender and sexually diverse youth in schools experience exclusion, which detrimentally affects their ability to cope with the consequences of minority stress and may lead to absenteeism or dropout. The purpose of the study is to highlight a pressing need for inclusive policies and practices to aid in enabling LGBTQ+ learners in schools.MethodsThis paper explores how multiple systems intersect to promote a sense of inclusion and engagement within the school environment and impact the resilience of LGBTQ+ youth in a rural school setting. This paper presents findings from a qualitative interpretive phenomenological study with twelve purposively selected self-identifying LGBTQ+ youth residing in a rural South African community. Data was gathered through semi-structured interviews.ResultsThis study shows the significance of teacher emotional support, addressing homophobic bullying, moving away from gender-based uniform prescriptions and designating some school bathrooms as gender-neutral to LGBTQ+ learners' resilience.ConclusionThe findings of this study demonstrate how certain schools in rural settings employ innovative methods to support LGBTQ+ learners despite limited resources and the absence of comprehensive, inclusive policies on gender and sexually diverse learners. The findings have implications for LGBTQ+ learners in rural community schools worldwide. Future longitudinal studies could focus on how school ecologies inclusive of teachers, parents and the wider community can foster the resilience of LGBTQ+ learners, particularly in rural community contexts.
Relationship of thyroid parameters with chronic inflammation in patients with euthyroid type 2 diabetes
Authors: Shi Wei , Chen Dan , Chen Wei , Chen Yulu , Fu Xiaoling , Xiao Yong , Duan Wei , Zhang Jing 
Published: October 2024

AimsWe evaluated the association of multiple thyroid parameters with the levels interleukin 6 (IL6) and interleukin 8 (IL8) in patients with euthyroid type 2 diabetes (T2D).MethodsA total of 166 adults with euthyroid T2D were examined. Serum IL6, IL8, triiodothyronine (FT3), free thyroxin (FT4), thyroid-stimulating hormone (TSH), five thyroid sensitivity indexes (FT3/FT4, TSH index [TSHI], thyrotroph T4 resistance index [TT4RI], thyroid feedback quantile-based index by FT3 [TFQIFT3], and TFQIFT4), and biochemical parameters were determined.ResultsThe median age was 64 years (IQR: 54.75,70) and the median duration of diabetes was 10 years (IQR: 3,18). Patients with high levels of IL6 (≥2.38 pg/mL) had lower levels of FT3 and TFQIFT3 (P&lt;0.05). Patients with high levels of IL8 (≥18.1 pg/mL) had lower levels of TSH and higher levels of FT4 (P&lt;0.05). IL6 was negatively correlated with FT3 (r=−0.359, P&lt;0.001), TFQIFT3 (r=−0.273, P=0.009), and FT3/FT4 (r=−0.22, P=0.037). IL8 was negatively correlated with TSH (r=−0.256, P=0.01), TSHI (r=−0.226, P=0.033), and TT4RI (r=−0.244, P=0.021). Binary logistic regression analysis with multiple adjusted models showed that a high level of IL6 was negatively associated with FT3 (aOR: 0.529; 95%CI: 0.302, 0.926, P=0.026), and that a high level of IL8 was negatively associated with TSH (aOR: 0.343; 95%CI: 0.155, 0.759; P=0.008) and TT4RI (aOR: 0.398;95%CI: 0.191, 0.831; P=0.014).ConclusionPatients with euthyroid T2D who had lower levels of FT3 had significantly higher levels of IL6, and those with lower levels of TSH and TT4RI had significantly higher levels of IL8.
Modeling the interaction between powder particles and laser heat sources
Authors: Baloyi P. , Desai D. A. , Arthur N. K. K. , Pityana S. L. 
Published: October 2024

This study investigates the spheroidization of titanium Ti-6Al-4V powder particles using numerical models developed in Abaqus and OpenFOAM. Spherical particles are crucial in powder-based additive manufacturing due to their superior flowability, packing density, and mechanical properties, enhancing printing precision and the quality of final products. While conventional techniques such as gas atomization and plasma spheroidization have been extensively researched, the potential of laser spheroidization remains underexplored. To address this gap, detailed numerical analyses of laser spheroidization were conducted, modeling heat transfer from the laser to powder particles using a transient uncoupled heat transfer method with latent heat considerations, while particle deformation was simulated with a phase-fraction-based interface-capturing approach integrated with Navier-Stokes equations. The results, validated against analytical models, indicate that particles within the 20–80 μm range experience optimal spheroidization within a 0.005-second residence time under laser heating, with particles smaller than 30 μm reaching evaporation temperatures of 5,000°C, while larger particles reshape without evaporating under a typical heat flux of 94 MW/m2 (1.8 kW laser power). This study demonstrates that laser spheroidization of Ti-6Al-4V powder can potentially increase powder yield by 10%, offering higher power density and shorter melting times compared to plasma spheroidization, thus presenting a more efficient alternative for achieving spherical particles of specific sizes.