bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bisimilarity is not Borel
Authors: SÁNCHEZ TERRAF PEDRO 
Published: December 2015

We prove that the relation of bisimilarity between countable labelled transition systems (LTS) is Σ11-complete (hence not Borel), by reducing the set of non-well orders over the natural numbers continuously to it.This has an impact on the theory of probabilistic and non-deterministic processes over uncountable spaces, since logical characterizations of bisimilarity (as, for instance, those based on the unique structure theorem for analytic spaces) require a countable logic whose formulas have measurable semantics. Our reduction shows that such a logic does not exist in the case of image-infinite processes.
A multilevel analysis of the relationship between parental migration and left-behind children’s macronutrient intakes in rural China
Authors: Zhang Nan , Bécares Laia , Chandola Tarani 
Published: December 2015

AbstractObjectiveChina’s internal migration has left 61 million children living apart from their parent(s) in rural areas. The present study aimed to examine whether the relative contributions of macronutrients (protein, fat and carbohydrate) to total energy intake differ between children left behind by the father or mother, compared with children from intact families.DesignDrawing on a longitudinal study, the China Health and Nutrition Survey (1997–2009), multilevel modelling analyses (level 1: occasions; level 2: children; level 3: villages) were performed.SettingData from rural communities in nine provinces in China.SubjectsRural children (n975; 555 boys and 420 girls) from 140 villages.ResultsAmong boys of school age, being left behind by the father tended to reduce the relative protein intake by 0·70 % (P<0·01) compared with boys from intact families. Being left behind by at least the mother was more detrimental for young boys under the age of 6 years than paternal migration, reducing relative protein intake by 1·14 % (P<0·05). Parental migration was associated with a significant increase in young boys’ relative fat intake by 2·60 % (P<0·05). No significant associations were found for girls. Results suggest left-behind boys, especially in early life, are subject to a higher-fat and lower-protein diet compared with non-left-behind boys. This may put them at increased risk of being overweight or obese, or of suffering from stunted growth, when they grow up.ConclusionsPublic health policies should recognise the influences of parental migration on boys, especially maternal migration, and encourage a more balanced diet for children in rural China.
COLA cuts in state-local pensions
Authors: MUNNELL ALICIA H. , AUBRY JEAN-PIERRE , CAFARELLI MARK 
Published: December 2015

AbstractAlthough it is often assumed that public workers have greater benefit protections than their private sector counterparts covered by the Employees Retirement Income Security Act of 1974, this paper finds that state and local governments – particularly those with generous cost-of-living adjustments (COLAs), fewer benefit protections, and financial pressures on the plan and the sponsoring government – cut COLAs for current workers and, often, for retirees. In most instances, these cuts were upheld by the courts. While the pace of COLA cuts has slowed, they are likely to reappear if plans come under renewed financial pressures.
An audit of the quality of HCR-20 violence risk assessments in a low secure service
Authors: Sen Piyal , Lindsey Simone , Chatterjee Nilanjan , Rama-Iyer Rajesh , Picchioni Marco 
Published: December 2015

AbstractIntroductionThe HCR-20 is one of the most popular structured clinical judgement tools used in forensic settings; yet, there are no published tools to assess the quality of its use. This study used the CAI-V, a tool to assess the competency of those carrying out risk assessment, to develop a quality tool for the use of HCR-20.MethodThe audit was carried out between July 2012 and July 2013 on all patients resident in St Andrew’s Essex, a low secure unit. The results of the first audit led to an action plan for clinical improvement, subsequently re-audited a year later.ResultsMost of the HCR-20 ratings scored in the competent range in both audits, but the greatest weakness was identified in the treatment planning section. The re-audit showed improvement, but there remained areas for development.DiscussionThe audit highlighted broad areas of improvement like the need for full multidisciplinary involvement, more attention to formulation, and the need for greater consultation and information gathering from outside professionals and family members. The quality tool developed could be adapted to the requirements of any service, and used accordingly.
PRN medication: beliefs and practices of psychiatrists and nurses working in PICUs and secure units
Authors: Haw Camilla , Sasegbon Helen , Ismail Imadeldin , Pushpanathan Malathi 
Published: December 2015

AbstractIntroductionPRN (as required) medication is commonly used in inpatient psychiatry but little is known about staff opinions concerning its use.Aims &amp; objectivesToexplore views about PRN medication among nurses and psychiatrists working in PICUs or secure care at a charitable hospital.MethodA structured questionnaire with visual analogue scales was used to examine staff views about PRN medication. Participants were: 21 PICU nurses, 20 nurses working on medium secure admission units (MSAUs) and 27 psychiatrists. Inquiry was made about preferences and avoidance of PRN drugs and when PRN administration becomes rapid tranquillisation (RT).ResultsNurses working in PICUs and MSAUs held similar views about PRN medication. Nurses were more in favour of PRN medication than psychiatrists, whereas psychiatrists felt more strongly that PRN sedation was sometimes over-used. PICU staff favoured promethazine whereas non-PICU staff preferred lorazepam/lorazepam and haloperidol combined. There was no consensus as to when PRN administration becomes RT.ConclusionsNurses hold more positive views about PRN sedation than psychiatrists. Despite the ECG requirement, many staff favour haloperidol. The NICE definition of RT was not quoted by most participants. RT and PRN medication is a grey area which deserves further exploration.
The DiViSA’s Predictive Validity by Age: An Objective Online Test of Attention
Authors: Santacreu J. , Quiroga M. A. 
Published: December 2015

AbstractThe purpose of this study was to analyze the DiViSA’s predictive validity in school-age children. To do so, two groups of school-age children were compared: one with low school achievement (N = 1,174), and one with typical development (N = 1,426). The obtained results show that: (1) in all grades, children with poor school performance exhibited lower levels of attention and task organization, greater hastiness, and made more commission errors; (2) the combination of variables that best differentiated between groups was not the same in all grades; (3) level of organization improved with age in the low-school-achievement group, and did not in the typical-development group; (4) the data regarding sensitivity (81% to 93%) and specificity (79% to 90%), for the first time computed for each grade separately, support the test’s predictive validity in the grades we evaluated. The discussion focuses on the DiViSA test’s usefulness in diagnosing attention problems. It is the first computerized test to include separate scores for: (a) how children complete the task (organization) and (2) the source of their errors (distraction or hastiness).
An Explanatory Model of Poverty from the Perspective of Social Psychology and Human Rights
Authors: Pérez-Muñoz Alfonso , Chacón Fernando , Martínez Arias Rosario 
Published: December 2015

AbstractPoverty is a social problem, entailing not only an economical perspective but above all a human and social issue. Poverty is promoted, justified and maintained by unique individuals and groups by means of our own attitudes, interests and behavior, as well as with our social structures and social relationships. From this interactive, psychosocial and sociostructural perspective, and also considering poverty as adenial of basic human rights(UNDP, 1998), we carried out a study with the primary objective to design and verify anExplanatory Model of Poverty.This research may helps to increase the validity of diagnostics and the effectiveness of interventions. Most of the hypotheses were accepted during the analysis and verification of the Model (p< .001), with data fitting the Model (CFI: 1 RMSEA: .025: LO90: 0 – HI90: .061. RMR: .008). These results, if replicated in new investigations, could have the following implications: (a) the need for a broad and comprehensive definition of poverty including its effects, processes and causes; (b) the need for everybody to accept the social responsibility in the prevention and solution to poverty; and (c) the need to conduct longitudinal interventions with scientific methodology and social participation.
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas
Authors: Wu Kui , Zhang Xin , Li Fuqiang , Xiao Dakai , Hou Yong , Zhu Shida , Liu Dongbing , Ye Xiaofei , Ye Mingzhi , Yang Jie , Shao Libin , Pan Hui , Lu Na , Yu Yuan , Liu Liping , Li Jin , Huang Liyan , Tang Hailing , Deng Qiuhua , Zheng Yue , Peng Lihua , Liu Geng , Gu Xia , He Ping , Gu Yingying , Lin Weixuan , He Huiming , Xie Guoyun , Liang Han , An Na , Wang Hui , Teixeira Manuel , Vieira Joana , Liang Wenhua , Zhao Xin , Peng Zhiyu , Mu Feng , Zhang Xiuqing , Xu Xun , Yang Huanming , Kristiansen Karsten , Wang Jian , Zhong Nanshan , Wang Jun , Pan-Hammarström Qiang , He Jianxing 
Published: December 2015

AbstractThe landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scale sequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma.
Emotional mimicry signals pain empathy as evidenced by facial electromyography
Authors: Sun Ya-Bin , Wang Yu-Zheng , Wang Jin-Yan , Luo Fei 
Published: December 2015

AbstractFacial mimicry has been suggested to be a behavioral index for emotional empathy. The present study is the first to investigate the link between facial muscle activity and empathy for pain by facial electromyographic (EMG) recording while observers watched videos depicting real-life painful events. Three types of visual stimulus were used: an intact painful scene and arm-only (needle injection) and face only (painful expression) scenes. Enhanced EMG activity of the corrugator supercilii (CS) and zygomaticus major (ZM) muscles was found when observers viewed others in pain, supporting a unique pain expression that is distinct from the expression of basic emotions. In the intact video stimulus condition, CS activity was correlated positively with the empathic concern score and ZM activity, suggesting facial mimicry mediated empathy for pain. Cluster analysis of facial EMG responses revealed markedly different patterns among stimulus types, including response category, ratio and temporal dynamics, indicating greater ecological validity of the intact scene in eliciting pain empathy as compared with partial scenes. This study is the first to quantitatively describe pain empathy in terms of facial EMG data. It may provide important evidence for facial mimicry as a behavioral indicator of pain empathy.
Partial Geometric Frustration in Inorganic Supramolecular Spin Systems with One-Dimensional Trigonally Aligned Magnetic Chains ∞1(MCl4)2− (M = Fe2+, Co2+)
Authors: Jiang Xiao-Ming , Li Xiao-Guo , Zhang Ming-Jian , Liu Zhi-Fa , Liu Yong , Liu Jun-Ming , Guo Guo-Cong 
Published: December 2015

AbstractExploration of new spin systems with low-dimensional subunits have been of great interest in the past decades due to their interesting physical properties and potential applications in molecular spintronics. Two inorganic supramolecular complexes, (Hg3S2)(FeCl4) and (Hg3S2)(CoCl4), with trigonally aligned 1-D infinite magnetic ∞1(FeCl4)2− or ∞1(CoCl4)2− chains have been prepared by solid-state reactions. They exhibit 3-D long-range spin order with strong field dependence and field induced metamagnetic behavior. The intrachain and interchain magnetic coupling constants were estimated by DFT+U and DFT+U+SOC calculations and the both complexes can be regarded as partially frustrated spin systems. The spin Hamiltonian was constructed, the ground state is proposed to be incommensurate spiral spin order, which differs from the commensurate 120° spin structure ground state of fully frustrated trigonal case by a little canted angle. This study shows that cooperative magnetic ordering induced by geometric frustration can be realized in inorganic supramolecular systems assembled by weak van der Waals’ interactions.
Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies
Authors: Hounkpe Bidossessi Wilfried , Fiusa Maiara Marx Luz , Colella Marina Pereira , Nilkenes Gomes da Costa Loredana , Benatti Rafaela de Oliveira , Olalla Saad Sara T , Costa Fernando Ferreira , dos Santos Magnun Nueldo Nunes , De Paula Erich Vinicius 
Published: December 2015

AbstractDespite the detailed characterization of the inflammatory and endothelial changes observed in Sickle Cell Disease (SCD), the hierarchical relationship between elements involved in the pathogenesis of this complex disease is yet to be described. Meta-analyses of gene expression studies from public repositories represent a novel strategy, capable to identify key mediators in complex diseases. We performed several meta-analyses of gene expression studies involving SCD, including studies with patient samples, as well as in-vitro models of the disease. Meta-analyses were performed with the Inmex bioinformatics tool, based on the RankProd package, using raw gene expression data. Functional gene set analysis was performed using more than 60 gene-set libraries. Our results demonstrate that the well-characterized association between innate immunity, hemostasis, angiogenesis and heme metabolism with SCD is also consistently observed at the transcriptomic level, across independent studies. The enrichment of genes and pathways associated with innate immunity and damage repair-associated pathways supports the model of erythroid danger-associated molecular patterns (DAMPs) as key mediators of the pathogenesis of SCD. Our study also generated a novel database of candidate genes, pathways and transcription factors not previously associated with the pathogenesis of SCD that warrant further investigation in models and patients of SCD.
Experience-dependent emergence of beta and gamma band oscillations in the primary visual cortex during the critical period
Authors: Chen Guang , Rasch Malte J. , Wang Ran , Zhang Xiao-hui 
Published: December 2015

AbstractNeural oscillatory activities have been shown to play important roles in neural information processing and the shaping of circuit connections during development. However, it remains unknown whether and how specific neural oscillations emerge during a postnatal critical period (CP), in which neuronal connections are most substantially modified by neural activity and experience. By recording local field potentials (LFPs) and single unit activity in developing primary visual cortex (V1) of head-fixed awake mice, we here demonstrate an emergence of characteristic oscillatory activities during the CP. From the pre-CP to CP, the peak frequency of spontaneous fast oscillatory activities shifts from the beta band (15–35 Hz) to the gamma band (40–70 Hz), accompanied by a decrease of cross-frequency coupling (CFC) and broadband spike-field coherence (SFC). Moreover, visual stimulation induced a large increase of beta-band activity but a reduction of gamma-band activity specifically from the CP onwards. Dark rearing of animals from the birth delayed this emergence of oscillatory activities during the CP, suggesting its dependence on early visual experience. These findings suggest that the characteristic neuronal oscillatory activities emerged specifically during the CP may represent as neural activity trait markers for the experience-dependent maturation of developing visual cortical circuits.
A 3-day EGCG-supplementation reduces interstitial lactate concentration in skeletal muscle of overweight subjects
Authors: Most Jasper , van Can Judith G P , van Dijk Jan-Willem , Goossens Gijs H. , Jocken Johan , Hospers Jeannette J. , Bendik Igor , Blaak Ellen E. 
Published: December 2015

AbstractGreen tea, particularly epigallocatechin-3-gallate (EGCG), may affect body weight and composition, possibly by enhancing fat oxidation. The aim of this double-blind, randomized placebo-controlled cross-over study was to investigate whether 3-day supplementation with EGCG (282mg/day) stimulates fat oxidation and lipolysis in 24 overweight subjects (age = 30 ± 2yrs, BMI = 27.7 ± 0.3 kg/m2). Energy expenditure, substrate metabolism and circulating metabolites were determined during fasting and postprandial conditions. After 6 h, a fat biopsy was collected to examine gene expression. In 12 subjects, skeletal muscle glycerol, glucose and lactate concentrations were determined using microdialysis. EGCG-supplementation did not alter energy expenditure and substrate oxidation compared to placebo. Although EGCG reduced postprandial circulating glycerol concentrations (P = 0.015), no difference in skeletal muscle lipolysis was observed. Fasting (P = 0.001) and postprandial (P = 0.003) skeletal muscle lactate concentrations were reduced after EGCG-supplementation compared to placebo, despite similar tissue blood flow. Adipose tissue leptin (P = 0.05) and FAT/CD36 expression (P = 0.08) were increased after EGCG compared to placebo. In conclusion, 3-day EGCG-supplementation decreased postprandial plasma glycerol concentrations, but had no significant effects on skeletal muscle lipolysis and whole-body fat oxidation in overweight individuals. Furthermore, EGCG decreased skeletal muscle lactate concentrations, which suggest a shift towards a more oxidative muscle phenotype.
Manipulating quantum information with spin torque
Authors: Sutton Brian , Datta Supriyo 
Published: December 2015

AbstractThe use of spin torque as a substitute for magnetic fields is now well established for classical operations like the switching of a nanomagnet. What we are describing here could be viewed as an application of spin torque like effects to quantum processes involving single qubit rotations as well as two qubit entanglement. A key ingredient of this scheme is the use of a large number of itinerant electrons whose cumulative effect is to produce the desired qubit operations on static spins. Each interaction involves entanglement and collapse of wavefunctions so that the operation is only approximately unitary. However, we show that the non-unitary component of the operations can be kept below tolerable limits with proper design. As a capstone example, we present the implementation of a complete CNOT gate using the proposed spin potential based architecture and show that the fidelity under ideal conditions can be made acceptably close to one.
The Role of Computer-Assisted Technology in Post-Traumatic Orbital Reconstruction: A PRISMA-driven Systematic Review
Authors: Wan Kelvin H. , Chong Kelvin K. L. , Young Alvin L. 
Published: December 2015

AbstractPost-traumatic orbital reconstruction remains a surgical challenge and requires careful preoperative planning, sound anatomical knowledge and good intraoperative judgment. Computer-assisted technology has the potential to reduce error and subjectivity in the management of these complex injuries. A systematic review of the literature was conducted to explore the emerging role of computer-assisted technologies in post-traumatic orbital reconstruction, in terms of functional and safety outcomes. We searched for articles comparing computer-assisted procedures with conventional surgery and studied outcomes on diplopia, enophthalmos, or procedure-related complications. Six observational studies with 273 orbits at a mean follow-up of 13 months were included. Three out of 4 studies reported significantly fewer patients with residual diplopia in the computer-assisted group, while only 1 of the 5 studies reported better improvement in enophthalmos in the assisted group. Types and incidence of complications were comparable. Study heterogeneities limiting statistical comparison by meta-analysis will be discussed. This review highlights the scarcity of data on computer-assisted technology in orbital reconstruction. The result suggests that computer-assisted technology may offer potential advantage in treating diplopia while its role remains to be confirmed in enophthalmos. Additional well-designed and powered randomized controlled trials are much needed.
Regulation of Shootin1 Gene Expression Involves NGF-induced Alternative Splicing during Neuronal Differentiation of PC12 Cells
Authors: Ergin Volkan , Erdogan Mutlu , Menevse Adnan 
Published: December 2015

AbstractShootin1 is a protein involved in neuronal polarization and has been shown to be a key molecule for the positive/negative feedback loop for axon induction required during neuronal symmetry breaking. To better understand the molecular basis of shootin1 dynamics, we analysed the regulatory pathways and the expressional status of shootin1 gene during NGF-induced neuronal differentiation. We demonstrated that the isoform-1 and isoform-2 of shootin1 is differentially expressed during neuronal differentiation. By blocking individual downstream pathways of NGF signalling, we found that PI3K/Akt pathway plays a major role in the expression of shootin1 isoform-2. Western blot and RT-PCR results showed that the isoform-1 of shootin1 is constitutively expressed, while the isoform-2 is expressed in a manner that is strictly dependent on NGF-stimulation. Isoform-specific RT-PCR results demonstrated that the differential expression of the isoform-1 and isoform-2 of shootin1 is a consequence of alternative splicing of shootin1 pre-mRNA, in response to NGF-signalling. Collectively these findings provide the first information on the molecular mechanisms regulating the expression of shootin1 gene and represent the first example of NGF-induced alternative splicing process that has a regulatory role in neuritogenesis.