bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant taxon‐character matrices: the future of morphological systematics
Authors: Laing Adam M. , Doyle Sharon , Gold Maria Eugenia Leone , Nesbitt Sterling J. , O'Leary Maureen A. , Turner Alan H. , Wilberg Eric W. , Poole Karen E. 
Published: March 2017

AbstractSimões et al. () argued that large matrices are linked to the construction of “problematic” characters, and that those characters negatively affect tree topology. In their re‐evaluation of two squamate datasets, however, Simões et al. () simply eliminated what they termed “problematic” characters, rather than recode them. This practice ignores potential sources of phylogenetic information and, if it were to be more widely followed, would inhibit the advancement of the field of systematics. Here, we defend the necessity and inevitability of large morphological (phenomic) datasets and discuss best practices for morphological data collection in contemporary phylogenetics.
Prevalence of obstructive sleep apnoea syndrome following oropharyngeal cancer treatment: A prospective cohort study
Authors: Loth A. , Michel J. , Giorgi R. , Santini L. , Rey M. , Elbaum J.‐M. , Roux N. , Giovanni A. , Dessi P. , Fakhry N. 
Published: March 2017

ObjectivesTo evaluate the prevalence of obstructive sleep apnoea syndrome (OSAS) in a population of patients treated for an advanced oropharyngeal cancer (AJCC Stage III or IV), depending on treatment strategy, and to evaluate its impact on quality of life.DesignProspective cohort study.SettingUniversity Teaching Hospital of La Conception, Marseille, France.ParticipantsFifty‐one disease‐free patients were included. Forty‐one patients received a combined chemoradiotherapy, while 10 patients were treated by surgery followed by chemoradiotherapy.Main Outcome MeasuresEvery patient underwent a formal sleep consultation and was asked to complete the Epworth Sleepiness Scale and EORTC QLQ C‐30 and the EORTC H&N 35 questionnaires. A home overnight respiratory polygraphy was performed in every subject.ResultsThe mean time between the end of cancer treatment and the OSAS analysis was 54.04 months [20; 84]. An OSAS was found in 25.49% of our patients. There was no significant difference between patients treated with either surgery (30%) or CRT (24.39%), P=.79. The EORTC QLQ C‐30 questionnaire showed a significant difference between positive and negative OSAS groups in the Global Health Status Scale (50.64 vs 67.11, P=.02) and in the fatigue item (35.04 vs 17.25, P=.03).ConclusionsOur population with advanced oropharyngeal cancer, whatever the treatment strategy it may be, was at risk of developing OSAS with negative impact on quality of life. A routine screening and treatment of OSAS seems necessary to improve the quality of life of patients treated for advanced oropharyngeal cancer.
Paternal care behaviour of the giant water bug Kirkaldyia deyrolli (Heteroptera: Belostomatidae) against ants
Authors: OHBA SHIN‐YA , MAEDA AIRI 
Published: March 2017

1. Although potentially vulnerable to predators, the offspring of subsocial insects are effectively protected by their parent(s). The female giant water bug Kirkaldyia deyrolli lays its egg masses on the vegetation above the water surface in aquatic environments and the males supply the eggs with water and guard them against cannibalistic females until hatchling dispersal. Field observations showed that egg masses are attacked by ants if the attending males are not present.2. Laboratory experiments were conducted to evaluate the effects of paternal care by K. deyrolli against the ant Tetramorium tsushimae by means of four treatments: attending male with ant approach (WM‐WA); no attending male with ant approach (NoM‐WA); attending male without ant approach (WM‐NoA); and no attending male without ant approach (NoM‐NoA).3. The rate of offspring survival was lower in the NoM‐WA group (45.3%) than in any other group, which showed similar offspring survival (WM‐WA = 80.4%, WM‐NoA = 75.1%, NoM‐NoA = 80.3%). Moreover, there were a total of 44 interactions between the attending male and ants in WM‐WA, and of these, a chemical compound was released by the attending male four times; this probably deterred ants from attacking because the ants went back to their colony.4. In conclusion, the attending male can protect its eggs from ant predators and its care has an important role. To the best of the authors' knowledge, this is the first report of Lethocerinae males protecting their egg masses from ants by means of physical and chemical defence.
Outcome measures for adult and pediatric hemophilia patients with inhibitors
Authors: Hermans Cedric , Auerswald Günter , Benson Gary , Dolan Gerry , Duffy Anne , Jiménez‐Yuste Victor , Ljung Rolf , Morfini Massimo , Lambert Thierry , Osooli Mehdi , Zupančić Šalek Silva 
Published: March 2017

AbstractRecent advancements in almost all aspects of hemophilia treatment have vastly improved patient care and management, and new and emerging treatments hold the promise of further progress. However, there remains a scarcity of data on long‐term outcomes in hemophilia, particularly among those patients with inhibitors, for whom no validated outcome assessment tools are currently available. At the 15th Zürich Haemophilia Forum, an expert panel reviewed the most important outcome measures in inhibitor patients and considered the challenges associated with assessing outcomes in this population. A framework for outcome assessment in inhibitor patients incorporates traditional hemophilia outcome measures, such as bleed frequency and mortality, alongside measures of health, functioning, disability, social participation, quality of life, and economic considerations. It is important to remember that inhibitor patients differ in their clinical needs, perspectives, and priorities according to age, inhibitor status, degree of joint disease, and activity levels; as a result, the relative importance of different outcome measures will change throughout an inhibitor patient's life. Challenges inherent in measuring long‐term outcomes in inhibitor patients include the small number of known patients, the subjective nature of many outcome assessment tools, and the risk of overburdening patients with repeated requests to complete questionnaires or participate in studies. Therefore, there is an urgent need to reach consensus on the most important and appropriate assessment tools for measuring outcomes in this population. These tools should ideally be standardized, easily applied, and internationally applicable in order to collect and generate quality outcome data.
Visual hallucinations in patients with acute stroke: a prospective exploratory study
Authors: Morenas‐Rodríguez E. , Camps‐Renom P. , Pérez‐Cordón A. , Horta‐Barba A. , Simón‐Talero M. , Cortés‐Vicente E. , Guisado‐Alonso D. , Vilaplana E. , García‐Sánchez C. , Gironell A. , Roig C. , Delgado‐Mederos R. , Martí‐Fàbregas J. 
Published: March 2017

Background and purposeThe incidence, underlying physiopathology, features and association with lesion topography of visual hallucinations in acute stroke have scarcely been investigated.MethodsPatients with a diagnosis of acute stroke (ischaemic or haemorrhagic) in any vascular territory, admitted within 24 h after the onset of symptoms, were consecutively included in the study. Patients with a previous history of psychosis or cognitive impairment were excluded. They and/or their caregivers answered a structured hallucination and sleep questionnaire at admission, within the first 15 days and at the clinical follow‐up 3–6 months after discharge. Lesion location (IMAIOS online atlas) and leukoaraiosis (Wahlund scale) were determined by magnetic resonance imaging or computed tomography scan. Subsets of patients also underwent a neuropsychological evaluation (N = 50) and an electroencephalogram (N = 33) before discharge.ResultsIn all, 77 patients with a mean age of 71 ± 12 years were included of whom 57.1% were men. The incidence of visual hallucinations was 16.7%. These hallucinations were mostly complex, in black and white and self‐limited. The appearance of hallucinations was not influenced by age, sex, neuropsychological performance during admission or modified Rankin scale score at discharge. Visual hallucinations were associated with occipital cortex lesions (P = 0.04), and with sleep disturbances during and before admission (P = 0.041 and P = 0.03 respectively).ConclusionsVisual hallucinations are relatively frequent in patients with acute stroke and they are self‐limited. Patients with occipital lesions and sleep disturbances are more likely to suffer them.
Long‐term white matter tract reorganization following prolonged febrile seizures
Authors: Pujar Suresh S. , Seunarine Kiran K. , Martinos Marina M. , Neville Brian G. R. , Scott Rod C. , Chin Richard F. M. , Clark Chris A. 
Published: March 2017

SummaryObjectiveDiffusion magnetic resonance imaging (MRI) studies have demonstrated acute white matter changes following prolonged febrile seizures (PFS), but their longer‐term evolution is unknown. We investigated a population‐based cohort to determine white matter diffusion properties 8 years after PFS.MethodsWe used diffusion tensor imaging (DTI) and applied Tract‐Based Spatial Statistics for voxel‐wise comparison of white matter microstructure between 26 children with PFS and 27 age‐matched healthy controls. Age, gender, handedness, and hippocampal volumes were entered as covariates for voxel‐wise analysis.ResultsMean duration between the episode of PFS and follow‐up was 8.2 years (range 6.7–9.6). All children were neurologically normal, and had normal conventional neuroimaging. On voxel‐wise analysis, compared to controls, the PFS group had (1) increased fractional anisotropy in early maturing central white matter tracts, (2) increased mean and axial diffusivity in several peripheral white matter tracts and late‐maturing central white matter tracts, and (3) increased radial diffusivity in peripheral white matter tracts. None of the tracts had reduced fractional anisotropy or diffusivity indices in the PFS group.SignificanceIn this homogeneous, population‐based sample, we found increased fractional anisotropy in early maturing central white matter tracts and increased mean and axial diffusivity with/without increased radial diffusivity in several late‐maturing peripheral white matter tracts 8 years post‐PFS. We propose disruption in white matter maturation secondary to seizure‐induced axonal injury, with subsequent neuroplasticity and microstructural reorganization as a plausible explanation.
Synonymy and circum‐tropical biogeography of the Devonian calcareous alga Zeapora Penecke, 1894 (Chlorophyta, Bryopsidales)
Authors: Hubmann Bernhard , Reuter Markus 
Published: March 2017

AbstractThe taxonomy of Zeapora Penecke, 1894 has a long but inconsistent taxonomic history. Originally identified as cyclostomate bryozoan, it was later assigned to the trepostomate bryozoans, amphiporid stromatoporoids, thamnoporid tabulate corals and dasycladacean algae before it was finally classified as Halimedaceae or Udoteaceae. Based on newly collected material from the type locality in the Graz Paleozoic (Eastern Alps, Austria) the taxonomic description of the type species Z. gracilis is emended and the udoteacean genus Litanaella Schuysky & Schirschova, 1987 is placed in synonymy with Zeapora. Following this opinion, Zeapora remains no longer endemic in the alpine Noric Terrane but shows a peculiar circum‐tropical distribution during the Early to Middle Devonian similar to modern Halimeda.
Ceria‐doped scandia‐stabilized zirconia (10Sc2O3·1CeO2·89ZrO2) as electrolyte for SOFCs: Sintering and ionic conductivity of thin, flat sheets
Authors: Escardino Agustín , Belda Adriana , Orts Maria‐Jose , Gozalbo Ana 
Published: March 2017

AbstractIn this study, thin, flat sheets, about 90 μm thick, were prepared from ceria‐doped scandia‐stabilized zirconia with molecular formula 10Sc2O3·1CeO2·89 ZrO2 (10Sc1CeSZ) by tape casting and subsequent sintering at different thermal cycles. A sintering thermal cycle was selected that yielded defect‐free flat sheets, with practically negligible porosity (between 0.35% and 0.10%) and average grain diameters ranging from 1.32 to 6.30 μm. Ionic conductivity at 600°C was as high as 21 mS/cm. Ionic conductivity increased with average grain diameters up to 2.7 μm. At higher average grain diameters, conductivity remained practically constant.
Impact of diabetic ketoacidosis management in the medical intensive care unit after order set implementation
Authors: Laliberte Benjamin , Yeung Siu Yan Amy , Gonzales Jeffrey P 
Published: March 2017

Abstract

Objective
To determine the rate of compliance to the 2006 and 2009 ADA DKA guidelines in the medical intensive care unit (MICU) at a large academic medical centre after the implementation of a computerised DKA order set and protocol.

Methods
Retrospective chart review of adult patients with DKA admitted to the MICU. Results of pre-order set (PRE) were compared to those of data post-order set (POST). The primary outcome was a composite administration of intravenous fluid resuscitation in the first 24 h, insulin bolus and initial insulin infusion rate.

Key findings
Twelve of 60 patients (20%) in the PRE group received treatment compliant with the 2006 guidelines versus 14 of 55 patients (25.5%) in the POST group (OR 1.22 95% CI 0.44 to 3.4, P = 0.51). Compliance to the 2009 guidelines was significantly higher in the POST group (31.7% versus 65.5%, OR 4.44 95% CI 1.8 to 10.92, P = 0.0004). Compliance for individual components was 26.7% versus 70.9% for fluid resuscitation (P = 0.0001), 55% versus 49.1% for insulin bolus (P = 0.58) and 60% versus 81.3% for initial insulin infusion rate (P = 0.014), respectively. Time to DKA resolution was decreased (P = 0.04), and hypoglycaemia was increased (P = 0.0022).

Conclusion
Implementation of a computerised DKA order set and protocol was associated with improved compliance to the 2009 ADA DKA guidelines, 24-h fluid resuscitation, initial insulin infusion rate, time to DKA resolution and appropriate transition to subcutaneous insulin. However, patients in the POST implementation group were more likely to exhibit hypoglycaemia. Future assessment is warranted.
Influence of catastrophizing on pain intensity, disability, side effects, and opioid misuse among pain patients in primary care
Authors: Lazaridou Asimina , Franceschelli Olivia , Buliteanu Alexandra , Cornelius Marise , Edwards Robert R. , Jamison Robert N. 
Published: March 2017

There is increasing concern among primary care practitioners (PCPs) regarding medication misuse and noncompliance while attempting to effectively manage chronic pain patients prescribed opioids for pain. The aim of this study was to investigate the effect pain catastrophizing has on self‐reported pain intensity, disability, side effects, and opioid misuse in chronic pain patients prescribed opioids within primary care. Fifty‐six PCPs and 253 chronic pain patients prescribed opioids or considered for opioid therapy were recruited into the study. All patients completed baseline measures, including the Pain Catastrophizing Scale (PCS) and were followed for 6 months to monitor pain and opioid compliance. Patients were divided evenly based on median‐split scores on the PCS and participated in phone interviews at 1 and 6 months. The subjects repeated the baseline measures and completed measures of opioid compliance at the end of the study period. Patients who scored high on catastrophizing reported significantly greater pain intensity, activity interference, negative affect, and a higher percentage of medication‐related adverse effects compared with those lower on the Pain Catastrophizing Scale at the start of the study and over a 6‐month period (p < .01). In addition, those chronic pain patients classified as high pain catastrophizers reported significantly higher opioid misuse (p < .01). This study demonstrates the important role of pain catastrophizing among chronic pain patients who are prescribed opioid medication for pain within primary care. These findings support the benefits of carefully monitoring patients who are prescribed opioids in primary care and possible benefits of offering interventions to reduce pain catastrophizing.
Pain catastrophizing: An historical perspective
Authors: Neblett Randy 
Published: March 2017

AbstractPain catastrophizing has become an in increasingly popular subject in pain research. It has been found to be associated with self‐reported pain severity, depressive and anxiety symptoms, and disability. This construct is an important component of the well‐established, and continually evolving, Fear‐Avoidance Model of Chronic Pain. More recently, a Communal Model of Pain Catastrophizing has been proposed. The concept of pain catastrophizing has an interesting history. This article discusses the origins, various definitions, and conceptual evolution of the catastrophizing in clinical evaluation and research.
Collagen type XV and the ‘osteogenic status’
Authors: Lisignoli Gina , Lambertini Elisabetta , Manferdini Cristina , Gabusi Elena , Penolazzi Letizia , Paolella Francesca , Angelozzi Marco , Casagranda Veronica , Piva Roberta 
Published: March 2017

AbstractWe have previously demonstrated that collagen type XV (ColXV) is a novel bone extracellular matrix (ECM) protein. It is well known that the complex mixture of multiple components present in ECM can help both to maintain stemness or to promote differentiation of stromal cells following change in qualitative characteristics or concentrations. We investigated the possible correlation between ColXV expression and mineral matrix deposition by human mesenchymal stromal cells (hMSCs) with different osteogenic potential and by osteoblasts (hOBs) that are able to grow in culture medium with or without calcium. Analysing the osteogenic process, we have shown that ColXV basal levels are lower in cells less prone to osteo‐induction such as hMSCs from Wharton Jelly (hWJMSCs), compared to hMSCs that are prone to osteo‐induction such as those from the bone marrow (hBMMSCs). In the group of samples identified as ‘mineralized MSCs’, during successful osteogenic induction, ColXV protein continued to be detected at substantial levels until early stage of differentiation, but it significantly decreased and then disappeared at the end of culture when the matrix formed was completely calcified. The possibility to grow hOBs in culture medium without calcium corroborated the results obtained with hMSCs demonstrating that calcium deposits organized in a calcified matrix, and not calcium ‘per se’, negatively affected ColXV expression. As a whole, our data suggest that ColXV may participate in ECM organization in the early‐phases of the osteogenic process and that this is a prerequisite to promote the subsequent deposition of mineral matrix.
Long non‐coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non‐small cell lung cancer
Authors: Zhu Qingqing , Lv Tangfeng , Wu Ying , Shi Xuefei , Liu Hongbing , Song Yong 
Published: March 2017

AbstractNon‐small cell lung cancer (NSCLC) is the most prevalent type of lung cancer. The abnormal expression of many long non‐coding RNAs (lncRNAs) has been reported involved in the progression of various tumours, which can be used as diagnostic indicators or antitumour targets. Here, we found that the long non‐coding RNA 00312 was down‐regulated in paired NSCLC tissues and correlated with poor clinical outcome; decreased linc00312 expression in NSCLC was associated with larger and later stage tumours. Functional experiments showed that linc00312 could inhibit cell proliferation and promote apoptosis in vitro and in vivo. Furthermore, we found that HOXA5 could bind in the promoter of linc00312 and up‐regulated the expression of it. Moreover, linc00312 was down‐regulated in the plasma of NSCLC patients compared with that of healthy volunteers or other pulmonary diseases patients. Taken together, our findings indicated that linc00312 could be a novel diagnosis biomarker and a promising therapeutic target for NSCLC.
Solubility as a fundamental variable in the characterization of wall material by spray drying of food components: Application to microencapsulation of Bifidobacterium animalis subsp. lactis
Authors: Rodríguez‐Restrepo Yeimy A. , Giraldo Gloria I. , Rodríguez‐Barona Sneyder 
Published: March 2017

AbstractThe physical and chemical properties of wall materials used in the microencapsulation of active compounds obtained by spray drying determine their application and incorporation into food matrices. Mixtures of 20% wt/wt protein and gum arabic in the following proportions were spray‐dried: 75:25 50:50 25:75. The proteinaceous materials used were whole milk powder, soy protein isolate, and skimmed milk powder. The solubility, hygroscopicity, water activity, moisture, bulk density, and the morphology of the powders were evaluated. The physicochemical characterization revealed that increasing the gum arabic concentration in the dispersion to be encapsulated leads to increases in the hygroscopicity and solubility of the powders. In turn, the solubility was increased at low protein concentrations in skimmed milk powder. In conclusion, the physicochemical characterization of spray‐dried powders ensures that the selected wall material possesses the necessary requirements for application in various food matrices. The microorganism probiotics have been widely used in the food industry interested in improving the human health and can be conserved by spray drying using different wall materials.Practical applicationsThis study evaluated the physicochemical and morphological properties of mixtures with varying proportions of different wall materials and their application potential in the encapsulation of probiotic microorganisms as the Bifidobacterium animalis. Application of wall materials with a low solubility favored the stability of the probiotic strain encapsulated during storage; this property plays an important role for the subsequent application of the encapsulated food compound, either for release or for the retention of the compound encapsulated. In all cases, these evaluated materials could be used to partially replace gum arabic.