bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does washing insecticide-treated nets 20 times for experimental hut evaluations provide a suitable proxy for their end-of-life performance under household conditions?
Authors: Syme Thomas , Agbevo Abel , Fagbohoun Josias , N’dombidjé Boris , Nounagnon Judicael , Ahoga Juniace , Akpi Joël , Ngufor Corine 
Published: October 2024

Abstract

Background
Insecticide-treated nets (ITNs) are washed 20 times as part of experimental hut trials to simulate the loss of active ingredient (AI) occurring over their intended 3-year lifespan and estimate insecticidal durability. The ability of the 20-wash method to predict the end-of-life performance of ITNs has not been empirically validated.
Methods
We performed an experimental hut trial to compare the efficacy of new ITNs unwashed and washed 20 times to field-aged ITNs withdrawn from households three years post-distribution against a pyrethroid-resistant vector population in Covè, Benin. Four products from pyrethroid-only (Interceptor®), pyrethroid-piperonyl butoxide (PermaNet® 3.0), pyrethroid-pyriproxyfen (Royal Guard®) and pyrethroid-chlorfenapyr (Interceptor® G2) ITN types were tested. Net pieces were tested in bioassays and sent for chemical analysis to assess differences in surface AI bioavailability and total chemical content between washed and field-aged nets. Susceptibility bioassays were also performed to assess insecticide resistance in the Covè vector population.
Results
Mosquito mortality in experimental huts was similar or slightly higher with field-aged nets than washed nets with Interceptor® (11% vs 10% p = 0.339, OR = 1.19, 95% CIs: [0.84,1.69]), PermaNet® 3.0 (12% vs 18% p < 0.001, OR = 1.78, 95% CIs: [1.34,2.38]) and Royal Guard® (9% vs 14% p = 0.076, OR = 1.33, 95% CIs: [0.97,1.83]). Likewise, field-aged Royal Guard® induced a similar reduction in fertility to washed Royal Guard® (22% vs 29%, p = 0.066). In contrast, mortality was significantly lower with field-aged nets Interceptor® G2 compared to washed nets (54% vs 19%, p < 0.001, OR = 0.18, 95% CIs: [0.14,0.24]). Blood-feeding inhibition was higher with field-aged nets than washed nets across all ITN types. Retention of non-pyrethroid AIs was lower than the pyrethroid, particularly with field-aged nets (PermaNet® 3.0 (roof): 25% vs 68% p < 0.001, Royal Guard®: 27% vs 53% p < 0.001, Interceptor® G2: 14% vs 39% p < 0.001).
Conclusion
In this setting, the 20-wash method provided a suitable proxy for the end-of-life killing and sterilising performance of Interceptor®, PermaNet® 3.0 and Royal Guard® in experimental huts. In contrast, washing overestimated the end-of-life performance of Interceptor® G2 for mortality and underestimated the personal protection of all field-aged ITNs.
Evaluation of Planning and Strategic Management at Social Organization for Business Sustainability
Authors: Azmy Ahmad , Hutabarat Reynold Bachtiar 
Published: October 2024

AbstractThis research analyzes the evaluation of programs and strategic management planning of social organizations. A qualitative approach is used as part of photographing the state and potential of the organization for the greatest achievement as an educational organization with the best reputation. The process of collecting data by interview. The results showed that the Good to Great theoretical framework can be used as a tool for measuring or evaluating programs and strategic management of organizations by identifying various strengths and weaknesses that become spaces for organizational improvement, based on each characteristic of the principles studied. Research proves that the Discipline of People, Discipline of Ideas, and Discipline of Action in the framework of Good to Great theory can be applied and relevant as an evaluation framework in the context of a social organization in Indonesia. These three aspects show a sustainable business with superior programs according to organizational values. Keywords:Business Sustainability, Business Planning, Strategic Management, Social Organization
Identidad y atractivo turístico. Construyendo la imagen urbana del México posrevolucionario
Authors: Mercado López Eugenio 
Published: October 2024

La aparición del turismo en México no solo marcó el inicio de una importante actividad económica para el país, significó también una transformación en la forma de percibir y valorar las bellezas naturales y la diversidad de manifestaciones culturales materiales e inmateriales existente en su territorio.
En ese contexto, se muestra el proceso de difusión del turismo en México y su institucionalización como parte de las prioridades de los gobiernos posrevolucionarios, hasta alcanzar una primera etapa de auge de esa actividad en la década de 1930. En particular, se busca mostrar la influencia que ejerció el turismo en la formulación de programas de gobierno, una legislación orientada a la protección del patrimonio urbano y arquitectónico, así como en la configuración de poblaciones típicas y centros históricos del país.
A partir de notas de prensa, el testimonio escrito de actores políticos e intelectuales de esa época, textos especializados, legislación y programas de gobierno, se identifica y reconstruye la relación entre el turismo y el patrimonio cultural de México en una temporalidad que abarca el final del siglo XIX y las cuatro primeras décadas del siglo XX. Con ello se contribuye al conocimiento de una etapa escasamente abordada en la historia del turismo en México y permite mostrar la verdadera dimensión, hasta ahora poco reconocida, de la influencia que esa actividad tuvo en la construcción de la cultura nacional durante la etapa posrevolucionaria, influencia que sigue teniendo profundas repercusiones hasta la actualidad.
Los inicios del turismo en México durante la segunda mitad del siglo xix y el Porfiriato a través de la prensa
Authors: Pérez Alfaro María Magdalena 
Published: October 2024

Este trabajo busca ofrecer una aproximación a los inicios del turismo en México, teniendo como fuente principal la prensa publicada en el periodo que va de la segunda mitad del siglo xix al fin del porfiriato. El objetivo es analizar los indicios que ofrece esta fuente primaria para conocer la manera en que se desarrolló el viaje turístico en nuestro país desde su “llegada” hasta su adopción por la elite porfiriana. También se recuperan las evidencias del establecimiento de comercios, servicios, transportes y actividades lucrativas asociados al turismo que permiten afirmar que, a partir de la década de 1880, comenzó a desarrollarse una incipiente industria turística en nuestro país.
Determinant state earnings qualities better than Private Pharmaceutical Companies
Authors: Putra Indra Lukmana , Maulana Nurefa , Suliswanto Muhammad Sri Wahyudi 
Published: October 2024

Purpose: Comparative Earning Quality of State and privately pharmaceutical companies listed on Indonesian Stock Exchange (BEI) between 2019-2023 period with liquidity, profitability, solvency and efficiency ratio.
Methodology/approach: After collecting the necessary data, appropriate financial ratios and descriptive statistical techniques are used to analyze, interpret and provide a brief overview of the data collected. the comparison involves two state-owned and two privately-owned pharmaceutical discretionary accruals and earnings persistence for earnings quality, and net profit margin, current ratio, debt-to-equity ratio, and total asset turnover for financial performance measurements.
Findings: net profit margin, current ratio, debt to equity ratio, dan total asset turnover have significant differences in the variables private are superior to those of state pharmaceutical companies. This recommends the importance of improving earnings quality of State pharmaceutical companies
Practical implications: these companies should refrain from earnings manipulation to foster strong and high-quality financial performance, particularly within Indonesia's pharmaceutical sector.
Originality/value: This comparison aims to contribute to financial management research by providing insights into the performance of different types of pharmaceutical companies based on earnings quality and financial statement ratios, thus offering academic contributions to the field.
Australia y Perú Oportunidades de Negocios Pro TLC
Authors: Giudice Baca Victor , Ruiz Rivera César Augusto 
Published: October 2024

La presente Investigación tiene como Primer Objetivo identificar las oportunidades de Negocios con el TLC firmado por Perú y Australia el 18 de Febrero 2018. Se ha resuelto este objetivo, proponiendo 20 productos con Ventajas Competitivas en un Mercado de 25 millones de habitantes y 45 mil dólares USA percapita al Año. Un segundo objetivo crucial ha sido lograr que un total de 20 productos peruanos ingresen al Mercado de Australia con una Liberación Arancelaria de 96%. Australia es un país puente para vincular al Perú con 14 países que rodean a Australia. Australia ha estimulado la expansión de Perú a la parte Sur de la Cuenca del Pacífico, llevando a la Cuenca Cinco Industrias ya existentes y con experiencia en el Comercio de exportación a Países Desarrollados. Perú se está estableciendo en un Mercado expansivo con poblaciones de ascendencia Europea en el Pacífico Sur (Australia y Nueva Zelanda). Las Cinco Industrias Peruanas favorecidas son: la Agricultura Moderna de Costa; la Industria de Conservas, Harina de Pescado, Aceite de Pescado y Comida para el ganado; también la Industria Textil de Polos y Camisas de algodón. Sorpresivamente se está exportando calzado al Merca do de Australia.
Effect of the Impurities on Drugs, Metabolism, and the Role of the Isoenzyme CYP3A4
Authors: Dreshaj A. , Dreshaj A. , Veseli D. , Sinanaj D. , Morina E. , Dehari S. , Dehari D. 
Published: October 2024

Abstract
Medicinal drugs have found great use in health treatment, and their use has increased after the COVID-19 pandemic. The health crisis caused by the coronavirus made the national authority for the control of medicinal drugs in Kosovo activates the institutional mechanisms for the control of drugs. Analyzing the excessive concentration of heavy metals in drugs and the adverse effects on the body since they reduce the positive effects of the drug. Methods. The research was conducted during the years 2020-2022 in Kosovo, the samples (over 30 patients) were studied, in 40 medical examinations, how the cytochrome P450 enzymatic system works and the impact on anti-inflammatory drugs. These drugs are metabolized by cytochrome CYP4502C9, which carries multiple inherited polymorphisms in the coding sequences, and by two varieties of this enzyme (cytochrome), CYP4502C9*2/3. Results. The presence of heavy metals in drugs is a concern related to neurotoxicity nephrotoxicity hepatic toxicity cardiovascular effects, immunotoxicity and carcinogenicity. The control of the content of elemental impurities is an important aspect of the quality assurance system of medicines and human health. Analytical studies of the amount of heavy metals in paracetamol samples X1 and X2 for the five metals studied, Arsenic in sample X1 showed a high presence of elements with a value of 5.07% among other metals. Nickel varies with a value of 4.91% in paracetamol X2 samples, the highest value for the analyzed plants. The analytical results of the studied medicinal plant "Matricaria Chamomilla" showed that the presence of Lead has a value of 3.7% compared to other metals in medicinal plants, while Mercury varies with 4.7%).Conclusions. Impurities in drugs often have unwanted or toxic effects on human health. Nowadays, knowledge about the negative effects of heavy metals is important for human health. Heavy metals enter the grass chain during the production process and impurities from natural raw materials.
Drain and Treat: A Rubber Dam Technique for Acute Periapical Abscess
Authors: Grover S. , Mala K. , D’Souza J. 
Published: October 2024

Abstract
Patients often report to the dental hospital with a complaint of toothache with extraoral swelling. Worried patients visit the dentist with a lot of apprehension. Acute dental infections with intraoral and extraoral swellings can be emergency and challenging to manage. Reduced mouth opening and severe pain may not allow the dentist to create an orthograde access to root canals. It ensues when the bacteria spread from the dental pulp to the surrounding periapical tissues accompanied by the formation of pus. If left untreated, these infections can be excruciatingly painful and pose a severe risk of spreading to facial spaces and finally, they may propagate to deep neck areas a ascend to intracranial sinuses. Hence, knowledge of its clinical management is of utmost importance. An acute periapical abscess has to be accurately diagnosed to render proper management of these maladies. Treating dentists should have a basic understanding of the pathophysiology, the suitable usage of antibiotics, the medical history of the patient, and standard treatment protocols. Therefore, this case report describes the management of an acute periapical abscess which was an emergency, and its conservative management.
Oral Clinical Manifestations in Patients with COVID-19: A Review
Authors: Dimova-Gabrovska M. , Shopova D. , Stamenova M. 
Published: October 2024

Abstract
One of the latest newly isolated diseases is COVID-19. COVID-19 is a highly contagious viral disease caused by SARS-CoV-2, a virus that belongs to the Coronaviridae family, Beta-coronavirus genus. To achieve the main purpose, a search was conducted in various databases (PubMed, Google Scholar, ResearchGate) and Internet sites with scientific Information by keywords: COVID-19, oral manifestations, oral pathology, orale Manifestationen, Läsionen der Mundschleimland, Geschmacksstörungen, Geruchsstörungen. The collected scientific Information is systematized according to 4 main criteria: etiology pathogenesis, oral manifestations, ways to improve the condition in the oral cavity, preventive measures.
The influence of the COVID-19 pandemic on pediatric hospitalizations for type 1 diabetes mellitus
Authors: Mănescu Măriuca , Mănescu Ion-Bogdan , Grama Alina 
Published: October 2024

Abstract

Objective
In this retrospective cohort study, we aimed to provide a snapshot of how the pandemic has affected pediatric type 1 diabetes mellitus (T1D) admissions in our hospital.

Methods
This study included 117 patients aged 0-18 classified based on period (pre-pandemic vs. pandemic period 2020-2022) and type of diagnosis at admission: new-onset T1D (nT1D) or diabetic ketoacidosis (DKA)-decompensated T1D. We investigated the effect of the COVID-19 pandemic on the demographic, clinical, and laboratory characteristics of these patients.

Results
Out of all T1D-related admissions, the proportion of admissions for nT1D increased compared to the pre-pandemic period: 71.6% vs 53.4%, p=0.048. Unrelated to the pandemic, the type of diagnosis at admission was associated with 1) the sex distribution (males – more nT1D admissions, females – more frequent DKA admissions, p=0.01), and 2) hospitalization duration (longer for nT1D admissions than for DKA-decompensated T1D admissions, p=0.001). Blood glucose and HbA1c levels were influenced neither by the pandemic period nor by the type of diagnosis. During the pandemic, a change in the T1D seasonality became apparent. A potential association pattern between new COVID-19 cases, number of T1D admissions, and stringency of restrictions was observed.

Conclusions
During the COVID-19 pandemic, the proportion of nT1D admissions increased, as well as the severity of DKA-decompensated T1D cases. In addition, the pandemic period brought about notable shifts in the seasonality of pediatric T1D.
Qualitative phytochemical screening and in vitro antioxidant activities of aqueous extracts of Rhaphiolepis bibas (Lour.) Galasso & Banfi
Authors: Kariuki Ibrahim Waweru , Ngugi Mathew , Maingi John 
Published: October 2024

Abstract
Reactive oxygen species causes harm to cell membranes and biomolecules, wherefore chronic diseases develop. Antioxidants scavenge such free radicals combating oxidative stress. This research aimed to determine the antioxidant potential of the aqueous stem bark, root and leaf extracts of Rhaphiolepis bibas against standards. DPPH radical scavenging activity was high from th stem bark extract at 72.33% with root extract at 65.85% and leaf extract at 55.91%, while ascorbic acid scavenged 89.53% of DPPH radicals. The leaf extract had the highest H2O2 scavenging activity of 91.92% with stem bark at 91.17% and the root extracts at 89.12%. The aqueous root extract of R. bibas had a significantly higher FRAP capacity in comparison to the leaf extracts and the stem bark. The abilities to chelate iron by the leaf extract were statistically higher compared to the root and stem bark extracts. Stem bark extracts had the highest phenol content of about 149.44 followed by the root extract at 141.14 and the least amount of phenol was found in the aqueous leaf extract having 73.012 Gallic acid equivalent/g. The root extracts had the highest total flavonoid 377.66-milligram quercetin equivalent/gram dry weight followed by stem bark extract at 255.72 and the least amount was found in aqueous leaf extract having 164.52 mgQE/g of sample dry weight. The existence of secondary metabolites linked to antioxidant action was shown by the qualitative phytochemical screening.
Considerations regarding the attitude of medical staff towards administrative risks within the Pathology Department
Authors: Popa Aurora Maria , Lazar Bianca Andreea , Marian Liviu Onoriu , Cotoi Ovidiu Simion , Voidăzan Septimiu 
Published: October 2024

Abstract

Objective
In the context of public health, there is a common misconception that only Romania’s system faces issues and generates societal dissatisfaction. However, globally, there is significant room for improvement, as the performance of the sector is often unsatisfactory. This paper presents findings from an exploratory study on the attitudes of medical personnel in pathology services towards managerial and administrative risks, supported by a survey that provides a wealth of useful information.

Methods
The survey encompassed a geographic area including the counties of Mureș, Harghita, Sibiu, and Alba, involving 12 healthcare units: 2 university hospitals, 2 county hospitals, and several municipal or town hospitals. These institutions housed anatomical pathology service structures staffed by approximately 240 physicians and assistants, with a ratio of 1 physician to 2.5 assistants. The questionnaire aimed to test four hypotheses through questions that invited respondents to select from formatted answers.

Results
Of the four hypotheses formulated and their corresponding items, only two were confirmed. This outcome suggests that the Romanian healthcare system is not unequivocally adaptable to the needs of medical product consumers. Specifically, the data indicate that hospitals face dire financial conditions amidst various challenges and vulnerabilities.

Conclusion
Differences of opinion between the two categories of respondents are evident in certain risk categories. This discrepancy arises from the specific nature of their activities and their respective contributions to ensuring the quality and efficiency of the service.
Determination of caffeine by micellar electrokinetic chromatography in different beverages
Authors: Uilăcan Alexandra , Stroia Denisa Gabriela , Hancu Gabriel 
Published: October 2024

Abstract
A fast, simple and cost-effective capillary electrophoresis (CE) method was developed for caffeine determination in different beverages (energy drinks, soft drinks). Because caffeine is neutral from electrophoretic point of view and migrates with the electroosmotic flow (EOF), micellar electrokinetic chromatography (MEKC) was chosen as the separation method. The optimum separation conditions consisted of 25 mM sodium tetraborate, 100 mM sodium dodecyl sulphate, pH 9.30, 20°C temperature, 20 kV voltage, 50 mbar/sec hydrodynamic injection, UV detection at 270 nm. Employing the optimized conditions caffeine was quantified in less than 3 minutes. The analytical performances of the method were verified in terms of accuracy, linearity, limit of detection and quantification, precision and robustness. The method was applied also to detect caffeine in coffee and tea. The advantage of MEKC over other analytical methods, particularly compared with the more frequently used HPLC methods, lies in its lower operating costs and higher environmental friendliness.
Helicobacter pylori and autoimmunity in atrophic gastritis - comparison of clinical, endoscopic and histopathological features
Authors: Filip Ana-Maria , Munteanu Sabrina-Nicoleta , Mocan Simona , Huțanu Dragoș , Pantea Monica , Negovan Anca 
Published: October 2024

Abstract

Objective
This study aims to investigate the clinical, endoscopic, biologic and histopathological differences between Helicobacter pylori-associated and autoimmune gastric atrophy.

Methods
A retrospective analysis was conducted on 95 patients diagnosed with either H. pylori-related corporal and antral atrophy (43 patients) or autoimmune corporal atrophic gastritis (52 patients).

Results
A significant male predisposition for H. pylori-associated atrophic changes in both the antrum and corpus regions (p=0.007, OR=3.24) was observed in comparison with autoimmune etiology of atrophy. While comorbidities and lifestyle factors showed similar distributions across groups, only unintentional self-reported weight loss demonstrated a significant association with H. pylori atrophy (p=0.0177, OR=3.94). Corporal erosions were strongly associated with antral and corporeal atrophic gastritis (p=0.04, OR=8.27), but the rest of mucosal lesions are comparable among groups. Interestingly, patients with H. pylori-related pangastric atrophy exhibited lower frequencies of altered triglyceride (p=0.018) and cholesterol (p=0.029) levels compared to the autoimmune group. Linear regression analysis identified low triglyceride levels as an independent predictor for H. pylori-associated antral and corporal atrophic gastritis (p=0.04) in endoscopic population with atrophy, but no hematological or clinical parameters were predictive for these changes.

Conclusions
Male patients are more likely to present with corpus atrophic gastritis associated with H. pylori infection than with an autoimmune etiology. Patients with atrophic gastritis tend to have similar clinical characteristics, except for dyslipidemia, which is more prevalent in those with H. pylori pangastritis. Corporal erosions are associated with active H. pylori infection in atrophic mucosa.