bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycemic control and disability‐free survival in hypoglycemic agent‐treated community‐dwelling older patients with type 2 diabetes mellitus
Authors: Morita Takuro , Okuno Tazuo , Himeno Taroh , Watanabe Keisuke , Nakajima Kumie , Koizumi Yumi , Yano Hiroshi , Iritani Osamu , Okuro Masashi , Morimoto Shigeto 
Published: February 2017

AimAlthough lower glycated hemoglobin (HbA1c) has been believed to be an important marker of improvement of glycemic control in order to maintain better quality of life for patients with diabetes mellitus, a too low HbA1cmight be harmful in older adults. We investigated whether this was the case with respect to risk of support/care‐need certification in community‐dwelling older patients with type 2 diabetes mellitus.MethodsWe analyzed 184 diabetes patients aged 65–94 years receiving glucose‐lowering medication/insulin. The end‐points were first support/care‐need certification and/or death. The relationships between four classes of HbA1cand risk of support/care‐need certification and/or death were determined using the Cox proportional hazards regression model.ResultsDuring 5 years, 42 first support/care‐need certifications and 13 deaths occurred. The association of HbA1cwith risk of support/care‐need certification after adjustment for age, sex and confounding variables was J‐shaped, with the nadir at an HbA1clevel of 6.5 to <7.0%, and with an increased risk of support/care‐need certification (HR 3.45, 95% CI 1.02–11.6,P= 0.046) at an HbA1clevel of <6.0% compared with the nadir. When compared with patients with HbA1c≥6.0%, those with HbA1c<6.0% showed a higher risk of support/care‐need certification as a result of dementia (HR 12.5, 95% CI 3.00–52.2,P= 0.001), but not as a result of arthralgia/fracture, stroke or other disorders.ConclusionsThese observations show that a too low HbA1cmight be associated with a later risk of incident disability as a result of dementia in community‐dwelling older diabetes patients.Geriatr Gerontol Int 2017; 17: 1858–1865.
The barriers and drivers of seafood consumption in Australia: A narrative literature review
Authors: Christenson Julia K. , O'Kane Gabrielle M. , Farmery Anna K. , McManus Alexandra 
Published: February 2017

AbstractAlthough seafood is considered to be an important part of a healthy and balanced diet, many Australians still do not consume the recommended amounts for good health. Fish is an excellent source of protein, omega‐3 fatty acids and other nutrients, and studies have shown that seafood‐rich diets can have a lower impact on the environment than diets high in other animal proteins. Concerns about health and sustainability have led to an increased interest in understanding consumers' attitudes toward seafood. This review aims to assess the current knowledge on drivers and barriers to seafood consumption in the Australian context. Systematic search strategies were used to identify relevant peer‐reviewed journal articles from three electronic databases (SCOPUS, Web of Science and Science Direct) and grey literature reports from targeted government and industry websites. Accepted studies investigated drivers and/or barriers to seafood consumption in Australia through qualitative, quantitative, or mixed method designs. Initial searches identified 504 publications from which fourteen met the criteria for the review process. The reviewed studies revealed that influences on seafood consumption in Australia are similar to those identified in other developed countries. The leading drivers of seafood consumption are health, taste, and convenience, while the main barriers are price, availability, concerns about quality, and a lack of confidence in selecting and preparing seafood. Some possible intervention strategies targeted toward these factors are explored in the discussion. Future research should focus on designing and implementing specific interventions so that their effectiveness in increasing seafood consumption in Australia can be assessed.
Private Military and Security Labour Migration: The Case of Fiji
Authors: Kanemasu Yoko , Molnar Gyozo 
Published: February 2017

AbstractPrivate military and security companies (PMSCs) are a fast‐growing global industry. While the rise of PMSCs and their activities have attracted much media coverage and growing scholarly attention, little is known about their sourcing of masses of military labour from the global South. This exploratory study examines the case of Fiji, whose thousands of ex/current disciplinary force personnel and unemployed men have been contracted by PMSCs to provide security work in Iraq and other high‐conflict areas. The article shows this to be an instance of unequal core‐periphery military labour trade, outlining its scale, processes and impacts on the migrants. It also illuminates how the migrants’ collective agency is demonstrated even under powerful structural constraints.
Amniotic fluid embolism: Pathophysiology from the perspective of pathology
Authors: Tamura Naoaki , Farhana Mustari , Oda Tomoaki , Itoh Hiroaki , Kanayama Naohiro 
Published: February 2017

AbstractAmniotic fluid embolism (AFE) is recognized as a type of syndrome characterized by the abrupt onset of hypoxia, hypotension, seizures, or disseminated intravascular coagulopathy (DIC), occurring during labor, delivery, or immediately postpartum, caused by the inflow of amniotic components into the maternal circulation. AFE is a rare condition but one of the most serious obstetrical complications, resulting in a high mortality rate among pregnant women. Despite earlier recognition and intensive critical management, we often encounter patients who unfortunately do not recover from the exacerbation of AFE‐related conditions. A major concern is that there are no effective evidence‐based therapies for AFE, because its pathophysiology is still not well understood. This article reviewed AFE, focusing on the pathology and currently proposed pathophysiology.
How Do Different Ways of Measuring Individual Differences in Zero‐Acquaintance Personality Judgment Accuracy Correlate With Each Other?
Authors: Hall Judith A. , Back Mitja D. , Nestler Steffen , Frauendorfer Denise , Schmid Mast Marianne , Ruben Mollie A. 
Published: February 2017

AbstractObjectiveThis research compares two different approaches that are commonly used to measure accuracy of personality judgment: the trait accuracy approach wherein participants discriminate among targets on a given trait, thus making intertarget comparisons, and the profile accuracy approach wherein participants discriminate between traits for a given target, thus making intratarget comparisons. We examined correlations between these methods as well as correlations among accuracies for judging specific traits.MethodThe present article documents relations among these approaches based on meta‐analysis of five studies of zero‐acquaintance impressions of the Big Five traits.ResultsTrait accuracies correlated only weakly with overall and normative profile accuracy. Substantial convergence between the trait and profile accuracy methods was only found when an aggregate of all five trait accuracies was correlated with distinctive profile accuracy. Importantly, however, correlations between the trait and profile accuracy approaches were reduced to negligibility when statistical overlap was corrected by removing the respective trait from the profile correlations. Moreover, correlations of the separate trait accuracies with each other were very weak.ConclusionsDifferent ways of measuring individual differences in personality judgment accuracy are not conceptually and empirically the same, but rather represent distinct abilities that rely on different judgment processes.
‘Your experiences were your tools’. How personal experience of mental health problems informs mental health nursing practice
Authors: Oates J. , Drey N. , Jones J. 
Published: February 2017

Accessible summaryWhat is known on the subject?

‘Expertise by experience’ has become an increasingly valued element of service design and delivery by mental health service providers.

The extent and influence of mental health professionals’ personal experience of mental ill health on clinical practice has seldom been interrogated in depth.

What this paper adds to existing knowledge?

We investigate how mental health nurses’ own personal experience of mental ill health informs their mental health nursing practice with particular reference to direct work with service users.

Participants said that personal experience could impact on work in three positive ways: to develop their relationship with service users, to enhance their understanding of service users and as a motivation for potential mental health nurses to join the profession.

This study moves the discussion of the state of mental health nurses’ mental health further towards the recovery and well‐being focus of contemporary mental health care, where ‘expertise by experience’ is highly valued.

What are the implications for practice?

We must address the taboo of disclosure within clinical nursing practice and debate the extent to which personal and professional boundaries are negotiated during clinical encounters.

AbstractIntroduction‘Expertise by experience’ is a highly valued element of service delivery in recovery‐oriented mental health care, but is unacknowledged within the mental health nursing literature.AimTo explore the extent and influence of mental health professionals’ personal experience of mental ill health on clinical practice.MethodTwenty‐seven mental health nurses with their own personal experience of mental ill health were interviewed about how their personal experience informed their mental health nursing practice, as part of a sequential mixed methods study.ResultsThe influence of personal experience in nursing work was threefold: first, through overt disclosure; second, through the ‘use of the self as a tool’; and third, through the formation of professional nursing identity.DiscussionMental health nurses’ experience of mental illness was contextualized by other life experiences and by particular therapeutic relationships and clinical settings. In previous empirical studies, nurses have cited personal experience of mental illness as a motivator and an aspect of their identity. In this study, there was also an association between personal experience and enhanced nursing expertise.Implications for practiceIf drawing on personal experience is commonplace, then we must address the taboo of disclosure and debate the extent to which personal and professional boundaries are negotiated during clinical encounters.
Genomic signatures of adaptation to wine biological ageing conditions in biofilm‐forming flor yeasts
Authors: Coi A. L. , Bigey F. , Mallet S. , Marsit S. , Zara G. , Gladieux P. , Galeote V. , Budroni M. , Dequin S. , Legras J. L. 
Published: February 2017

AbstractThe molecular and evolutionary processes underlying fungal domestication remain largely unknown despite the importance of fungi to bioindustry and for comparative adaptation genomics in eukaryotes. Wine fermentation and biological ageing are performed by strains ofS. cerevisiaewith, respectively, pelagic fermentative growth on glucose and biofilm aerobic growth utilizing ethanol. Here, we use environmental samples of wine and flor yeasts to investigate the genomic basis of yeast adaptation to contrasted anthropogenic environments. Phylogenetic inference and population structure analysis based on single nucleotide polymorphisms revealed a group of flor yeasts separated from wine yeasts. A combination of methods revealed several highly differentiated regions between wine and flor yeasts, and analyses using codon‐substitution models for detecting molecular adaptation identified sites under positive selection in the high‐affinity transporter geneZRT1. The cross‐population composite likelihood ratio revealed selective sweeps at three regions, including in the hexose transporter geneHXT7, the yapsin geneYPS6and the membrane protein coding geneMTS27. Our analyses also revealed that the biological ageing environment has led to the accumulation of numerous mutations in proteins from several networks, includingFlo11regulation and divalent metal transport. Together, our findings suggest that the tuning ofFLO11expression and zinc transport networks are a distinctive feature of the genetic changes underlying the domestication of flor yeasts. Our study highlights the multiplicity of genomic changes underlying yeast adaptation to man‐made habitats and reveals that flor/wine yeast lineage can serve as a useful model for studying the genomics of adaptive divergence.
The TORC1–Sch9–Rim15 signaling pathway represses yeast‐to‐hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica
Authors: Liang Shu‐Heng , Wu Heng , Wang Rui‐Rui , Wang Qiang , Shu Tao , Gao Xiang‐Dong 
Published: February 2017

SummaryThe yeast‐to‐hypha dimorphic transition is important for survival under nutrient starvation in fungi. The oleaginous yeast Yarrowia lipolytica grows in the oval‐shaped yeast form in glycerol media whereas it adopts a filamentous form in glucose media. It is not clear why this yeast responds differently to glycerol and glucose. Here, we show that glycerol blocks dimorphic transition even in the presence of glucose whereas glycerol depletion induces filamentous growth, suggesting that dimorphic transition is repressed in response to glycerol availability. We show that the repression of dimorphic transition in glycerol media is mediated by the TORC1–Sch9 signaling pathway as both TORC1 inhibition and the loss of YlSch9 cause hyperfilamentation. TORC1–Sch9 signaling inhibits the nuclear translocation of YlRim15, a protein kinase that positively regulates filamentous growth, preventing it from entering the nucleus to activate the transcription of genes implicated in filamentous growth. Interestingly, TORC1–Sch9 signaling appears not to inhibit YlRim15 in glucose media, which could explain why Y. lipolytica responds differently to glycerol and glucose. We identified MHY1, a transcription factor‐encoding gene known to be critical for filamentous growth, as one target regulated by the TORC1–Sch9–Rim15 signaling pathway. Our results provide new insights in the regulation of dimorphic transition in yeast.
Gene expression profiles in peripheral blood mononuclear cells correlate with salience network activity in chronic visceral pain: A pilot study
Authors: Gupta A. , Cole S. , Labus J. S. , Joshi S. , Nguyen T. J. , Kilpatrick L. A. , Tillisch K. , Naliboff B. D. , Chang L. , Mayer E. A. 
Published: February 2017

AbstractBackgroundDistinct gene expression profiles in peripheral blood mononuclear cells (PBMCs) consistent with increased sympathetic nervous system activity have been described in different populations under chronic stress. Neuroinflammatory brain changes, possibly related to the migration of primed monocytes to the brain, have been implicated in the pathophysiology of chronic pain. Irritable bowel syndrome (IBS) is a stress‐sensitive gastrointestinal disorder associated with altered brain‐gut interactions and increased sympathetic/vagal tone and anxiety. Reports about immune alterations in IBS are conflicting. This pilot study aimed to test how PBMC gene expression inflammatory profiles are correlated with altered brain signatures in the salience system.MethodsSixteen IBS and 16 healthy controls (HCs) completed resting state MRI scans. Gene expression profiles in PBMCs were assessed using human transcriptome array‐2. Bioinformatic analyses determined differential expression of PBMCs between IBS and HCs. Partial least squares, a multivariate analysis technique, was used to identify disease correlations between PBMC gene expression profiles and functional activity in the brain's salience network.Key ResultsRegions of the salience network, including the mid cingulate cortex, and mid and superior temporal gyrus were positively correlated with several pro‐inflammatory genes (interleukin 6, APOL2) in IBS, but negatively correlated with several anti‐inflammatory genes (KRT8, APOA4) in HCs.Conclusions & InferencesBased on rodent studies, one may speculate that chronically activated stress signaling pathways in IBS maintain a pro‐inflammatory state in the periphery. Alternatively, primed monocytes may migrate to the brain during stress, inducing regional neuroinflammatory changes in salience regions involved in the modulation of visceral sensitivity.
Sticking to cellulose: exploiting Arabidopsis seed coat mucilage to understand cellulose biosynthesis and cell wall polysaccharide interactions
Authors: Griffiths Jonathan S. , North Helen M. 
Published: February 2017

SummaryThe cell wall defines the shape of cells and ultimately plant architecture. It provides mechanical resistance to osmotic pressure while still being malleable and allowing cells to grow and divide. These properties are determined by the different components of the wall and the interactions between them. The major components of the cell wall are the polysaccharides cellulose, hemicellulose and pectin. Cellulose biosynthesis has been extensively studied in Arabidopsis hypocotyls, and more recently in the mucilage‐producing epidermal cells of the seed coat. The latter has emerged as an excellent system to study cellulose biosynthesis and the interactions between cellulose and other cell wall polymers. Here we review some of the major advances in our understanding of cellulose biosynthesis in the seed coat, and how mucilage has aided our understanding of the interactions between cellulose and other cell wall components required for wall cohesion. Recently, 10 genes involved in cellulose or hemicellulose biosynthesis in mucilage have been identified. These discoveries have helped to demonstrate that xylan side‐chains on rhamnogalacturonan I act to link this pectin directly to cellulose. We also examine other factors that, either directly or indirectly, influence cellulose organization or crystallization in mucilage.
Utility and Safety of Combined Interventional Catheterization and Electrophysiology Procedures in a Children's Hospital
Authors: ASAKI S. YUKIKO , ORCUTT JEFFREY W. , MIYAKE CHRISTINA Y. , JUSTINO HENRI , de la UZ CARIDAD M. , KIM JEFFREY J. , VALDES SANTIAGO O. , QURESHI ATHAR M. 
Published: February 2017

BackgroundInterventional cardiac catheterization (cath) and electrophysiology (EP) procedures are not routinely performed together. There are several perceived barriers affecting this practice, though there are also advantages for both the patient and practitioner to a combined approach.MethodsThis was a single‐center retrospective study reviewing combined cath and EP procedures with a preprocedural intention to intervene at Texas Children's Hospital from 2001 to 2014. We excluded procedures in which the intended procedure was purely diagnostic in nature.ResultsA total of 121 patients requiring 125 procedures were identified, of which 61 patients underwent 62 procedures that met our inclusion criteria. Potential subgroups of interest included adult congenital heart disease patients (26% of cohort), single ventricle anatomy (34%), and heterotaxy (19%) and collectively 58% of procedures involved a patient in one of these groups. The combined nature of the procedure did not preclude a cath or EP intervention in any patient. There were no mortalities. There were three adverse events, affecting 4.8% of procedures.ConclusionsCombined interventional cardiac cath and EP procedures in pediatric patients and those with congenital heart disease can be performed safely in a high‐volume center. These combined procedures save patients the risk and inconvenience of multiple procedures, and further investigation into cost savings is warranted.
Surveying the forest: A meta‐analysis, moderator investigation, and future‐oriented discussion of the antecedents of voluntary employee turnover
Authors: Rubenstein Alex L. , Eberly Marion B. , Lee Thomas W. , Mitchell Terence R. 
Published: February 2017

AbstractRecent narrative reviews (e.g., Hom, Mitchell, Lee, and Griffeth, 2012; Hom, Lee, Shaw, and Hausknecht, 2017) advise that it is timely to assess the progress made in research on voluntary employee turnover so as to guide future work. To provide this assessment, we employed a three‐step approach. First, we conducted a comprehensive meta‐analysis of turnover predictors, updating existing effect sizes and examining multiple new antecedents. Second, guided by theory, we developed and tested a set of substantive moderators, considering factors that might exacerbate or mitigate zero‐order meta‐analytic effects. Third, we examined the holistic pattern of results in order to highlight the most pressing needs for future turnover research. The results of Step 1 reveal multiple newer predictors and updated effect sizes of more traditional predictors, which have received substantially greater study. The results of Step 2 provide insight into the context‐dependent nature of many antecedent–turnover relationships. In Step 3, our discussion takes a bird's‐eye view of the turnover “forest” and considers the theoretical and practical implications of the results. We offer several research recommendations that break from the traditional turnover paradigm, as a means of guiding future study.
The impact of cognitive delay on pediatric heart transplant outcomes
Authors: Prendergast Christopher , McKane Meghann , Dodd Debra A. , Godown Justin 
Published: February 2017

AbstractThe presence of CD may be viewed as a relative contraindication to transplantation; however, its impact on pediatric HTx outcomes is poorly characterized. The aim of this study was to assess the impact of CD on pediatric HTx outcomes using academic progress as a surrogate measure of cognitive performance. The OPTN database was queried for all pediatric HTx recipients (2004‐2014) with reported academic progress. Multivariable analysis assessed the impact of DGL and the need for SE on post‐HTx graft survival. A total of 2245 children were included: 1707 (76%) within grade level, 269 (12%) with DGL, and 269 (12%) who required SE. The need for SE was not a risk factor for post‐HTx mortality; however, DGL was an independent risk factor for worse post‐HTx outcomes (AHR 1.4, 95% CI 1.02, 1.79, P=.03). Patients who require SE have similar outcomes compared to those without CD, likely secondary to significant parental involvement. Children with DGL demonstrate inferior post‐HTx survival, which could result from less parental oversight in children perceived to maintain compliance. Ensuring adequate social support for patients with evidence of CD may help to improve outcomes.