bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain network dysregulation, emotion, and complaints after mild traumatic brain injury
Authors: van der Horn Harm J. , Liemburg Edith J. , Scheenen Myrthe E. , de Koning Myrthe E. , Marsman Jan‐Bernard C. , Spikman Jacoba M. , van der Naalt Joukje 
Published: February 2016

AbstractObjectivesTo assess the role of brain networks in emotion regulation and post‐traumatic complaints in the sub‐acute phase after non‐complicated mild traumatic brain injury (mTBI).Experimental designFifty‐four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group‐matched for age, sex, education, and handedness) were included. Resting‐state fMRI was performed at four weeks post‐injury. Static and dynamic functional connectivity were studied within and between the default mode, executive (frontoparietal and bilateral frontal network), and salience network. The hospital anxiety and depression scale (HADS) was used to measure anxiety (HADS‐A) and depression (HADS‐D).Principal ObservationsRegarding within‐network functional connectivity, none of the selected brain networks were different between groups. Regarding between‐network interactions, patients with complaints exhibited lower functional connectivity between the bilateral frontal and salience network compared to patients without complaints. In the total patient group, higher HADS‐D scores were related to lower functional connectivity between the bilateral frontal network and both the right frontoparietal and salience network, and to higher connectivity between the right frontoparietal and salience network. Furthermore, whereas higher HADS‐D scores were associated with lower connectivity within the parietal midline areas of the bilateral frontal network, higher HADS‐A scores were related to lower connectivity within medial prefrontal areas of the bilateral frontal network.ConclusionsFunctional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions.Hum Brain Mapp 37:1645‐1654, 2016. © 2016 Wiley Periodicals, Inc.
Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo‐controlled trial
Authors: Villani Veronica , Zucchella Chiara , Cristalli Giovanni , Galiè Edvina , Bianco Francesco , Giannarelli Diana , Carpano Silvia , Spriano Giuseppe , Pace Andrea 
Published: February 2016

AbstractBackgroundFew studies have investigated the effect of vitamin E in reducing the cisplatin (CDDP)‐induced ototoxicity. This study evaluated vitamin E supplementation as a protecting agent against CDDP‐induced ototoxicity.MethodsPatients who started CDDP were randomly assigned to receive vitamin E supplementation at 400 mg per day (group 1) or placebo (group 2). Audiograms and evoked brainstem responses were obtained at baseline, and after 1, 2, and 3 months.ResultsTwenty‐three patients affected by solid malignancies were enrolled (13 in group 1 and 10 in group 2). At 1 month, a significant hearing loss in group 2 at both 2000 HZ (right ear: p = .05; left ear: p = .04) and 8000 HZ (right ear: p = .04; left ear: p = .03) was detected when compared to baseline values. Audiograms did not show significant changes. At 1 month, evoked brainstem responses remained unchanged in both arms without significant differences between groups.ConclusionThese preliminary findings confirm the neuroprotective properties of vitamin E against the CDDP‐induced ototoxicity. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2118–E2121, 2016
Intravital microscopy of the lung: minimizing invasiveness
Authors: Fiole Daniel , Tournier Jean‐Nicolas 
Published: February 2016

In vivo microscopy has recently become a gold standard in lung immunology studies involving small animals, largely benefiting from the democratization of multiphoton microscopy allowing for deep tissue imaging. This technology represents currently our only way of exploring the lungs and inferring what happens in human respiratory medicine. The interest of lung in vivo microscopy essentially relies upon its relevance as a study model, fulfilling physiological requirements in comparison with in vitro and ex vivo experiments. However, strategies developed in order to overcome movements of the thorax caused by breathing and heartbeats remain the chief drawback of the technique and a major source of invasiveness. In this context, minimizing invasiveness is an unavoidable prerequisite for any improvement of lung in vivo microscopy. This review puts into perspective the main techniques enabling lung in vivo microscopy, providing pros and cons regarding invasiveness.
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Photostimulation by femtosecond laser triggers restorable fragmentation in single mitochondrion
Authors: Wang Yintao , He Hao , Wang Shaoyang , Liu Yaohui , Hu Minglie , Cao Youjia , Kong Siukai , Wei Xunbin , Wang Chingyue 
Published: February 2016

Mitochondrial research is important to the study of ageing, apoptosis, and metabolic diseases. Over the years, mitochondria have been studied with stimulation by chemical agents in a global manner for basic and applied research. This approach lacks of precision and accuracy in terms of spatial and temporal resolution. Here we demonstrate a direct and well‐defined photostimulation targeting on single mitochondrial tubular structure using a tightly‐focused femtosecond (fs) laser that could precisely activate mitochondria at single tubule level to show restorable fragmentation and subsequent recovery after tens of seconds. In these two processes, a series of mitochondrial reactive oxygen species (mROS) flashes was observed and found critical to the mitochondrial fragmentation. Meanwhile, transient openings of mitochondrial permeability transition pores (mPTP) were seen with oscillations of mitochondrial membrane potential. These activities were crucial for the recovery through scavenging the mROS. Without the feedback mechanisms, the fragmented mitochondria could not return back to their original tubular structure. These interesting observations show that photostimulation by fs laser is an active, precise, clean and well‐defined approach to dissect the role of mitochondria in normal physiology and different kinds of diseases.
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Effect of etching with distinct hydrofluoric acid concentrations on the flexural strength of a lithium disilicate‐based glass ceramic
Authors: Prochnow Catina , Venturini Andressa B. , Grasel Rafaella , Bottino Marco C. , Valandro Luiz Felipe 
Published: February 2016

AbstractThis study examined the effects of distinct hydrofluoric acid concentrations on the mechanical behavior of a lithium disilicate‐based glass ceramic. Bar‐shaped specimens were produced from ceramic blocks (e.max CAD, Ivoclar Vivadent). The specimens were polished, chamfered, and sonically cleaned in distilled water. The specimens were randomly divided into five groups (n = 23). The HF1, HF3, HF5, and HF10 specimens were etched for 20 s with acid concentrations of 1%, 3%, 5%, and 10%, respectively, while the SC (control) sample was untreated. The etched surfaces were evaluated using a scanning electron microscope and an atomic force microscope. Finally, the roughness was measured, and 3‐point bending flexural tests were performed. The data were analyzed using one‐way analysis of variance (ANOVA) and Tukey's test (α = 0.05). The Weibull modulus and characteristic strength were also determined. No statistical difference in the roughness and flexural strength was determined among the groups. The structural reliabilities (Weilbull moduli) were similar for the tested groups; however, the characteristic strength of the HF1 specimen was greater than that of the HF10 specimen. Compared with the untreated ceramic, the surface roughness and flexural strength of the ceramic were unaffected upon etching, regardless of the acid concentration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 885–891, 2017.
Transformation of raw feather waste into digestible peptides and amino acids
Authors: Stiborova Hana , Branska Barbora , Vesela Tereza , Lovecka Petra , Stranska Milena , Hajslova Jana , Jiru Monika , Patakova Petra , Demnerova Katerina 
Published: February 2016

ABSTRACTBACKGROUNDMillions of tons of feather waste from the poultry industry are disposed of annually despite containing a high level of keratin. The aim of this study was to compare the hydrolysis of non‐treated feather waste using three different approaches (whole cell microbial digestion, enzymatic and chemical cleavage) and to test the use of hydrolysates as peptone substitutes in a culture medium.RESULTSAmong bacterial isolates, Pseudomonas sp. P5 exhibited the highest keratinolytic activity and efficiency to hydrolyse raw feather material. The hydrolysates contained up to 301 mg L−1 of free amino acids and 6.2 g L−1 of peptides. Hydrolysates obtained by digestion using semi‐purified keratinase from Pseudomonas sp. P5 were richer in amino acids (1191 mg L−1, 56% essential ones) but peptides were present in lower amounts (up to 3.3 g L−1). The third approach was feather treatment under mild alkaline conditions. This provided the highest amount of peptides (17.2 g L−1) but a significantly lower level of amino acids, especially the essential ones.CONCLUSIONSAll approaches tested could convert raw feather waste into products of commercial value with proven use in a cultivation medium. The level of peptides, their molecular size and amino acid composition was dependent on the method used. © 2016 Society of Chemical Industry
Downscaling regional climate model outputs for the Caribbean using a weather generator
Authors: Jones P. D. , Harpham C. , Burton A. , Goodess C. M. 
Published: February 2016

ABSTRACTLocally relevant scenarios of daily weather variables that represent the best knowledge of the present climate and projections of future climate change are needed by planners and managers to inform management and adaptation to climate change decisions. Information of this kind for the future is only readily available for a few developed country regions of the world. For many less‐developed regions, it is often difficult to find series of observed daily weather data to assist in planning decisions. This study applies a previously developed single‐site weather generator (WG) to the Caribbean, using examples from Belize in the west to Barbados in the east. The purpose of this development is to provide users in the region with generated sequences of possible future daily weather that they can use in a number of impact sectors. The WG is first calibrated for a number of sites across the region and the goodness of fit of the WG against the daily station observations assessed. Particular attention is focussed on the ability of the precipitation component of the WG to generate realistic extreme values for the calibration or control period. The WG is then modified using change factors (CFs) derived from regional climate model projections (control and future) to simulate future 30‐year scenarios centred on the 2020s, 2050s and 2080s. Changes between the control period and the three futures are illustrated not just by changes in average temperatures and precipitation amounts but also by a number of well‐used measures of extremes (very warm days/nights, the heaviest 5‐day precipitation total in a month, counts of the number of precipitation events above specific thresholds and the number of consecutive dry days).
Has the use of talc an effect on yield and extra virgin olive oil quality?
Authors: Caponio Francesco , Squeo Giacomo , Difonzo Graziana , Pasqualone Antonella , Summo Carmine , Paradiso Vito Michele 
Published: February 2016

AbstractThe maximization of both extraction yield and extra virgin olive oil quality during olive processing are the main objectives of the olive oil industry. As regards extraction yield, it can be improved by both acting on time/temperature of malaxation and using physical coadjuvants. It is well known that, generally, increasing temperature of malaxation gives an increase in oil extraction yield due to a reduction in oily phase viscosity; however, high malaxation temperature can compromise the nutritional and health values of extra virgin olive oil, leading to undesirable effects such as accelerated oxidative process and loss of volatile compounds responsible for oil flavor and fragrance. The addition of physical coadjuvants in olive oil processing during the malaxation phase, not excluded by EC regulations owing to its exclusively physical action, is well known to promote the breakdown of oil/water emulsions and consequently make oil extraction easier, thus increasing the yield. Among physical coadjuvants, micronized natural talc is used for olive oil processing above all for Spanish and Italian olive cultivars. The quality of extra virgin olive oil depends on numerous variables such as olive cultivar, ripeness degree and quality, machines utilized for processing, oil storage conditions, etc. However, the coadjuvants utilized in olive processing can also influence virgin olive oil characteristics. The literature highlights an increase in oil yield by micronized natural talc addition during olive processing, whereas no clear trend was observed as regards the chemical, nutritional and sensory characteristics of extra virgin olive oil. Although an increase in oil stability was reported, no effect of talc was found on the evolution of virgin olive oil quality indices during storage. © 2016 Society of Chemical Industry
Effect of Nd:YAG laser‐assisted non‐surgical periodontal therapy on clinical periodontal and serum biomarkers in patients with and without coronary artery disease: A short‐term pilot study
Authors: Javed Fawad , Kellesarian Sergio V. , Al‐Kheraif Abdulaziz A. , Ranna Vinisha , Qadri Talat , Yunker Michael , Malmstrom Hans , Romanos Georgios E. 
Published: February 2016

Background/ObjectiveWe hypothesized that nonsurgical‐periodontal‐therapy (NSPT) with adjunct Nd:YAG laser therapy is more effective in reducing periodontal inflammatory parameters (plaque index [PI], bleeding‐on‐probing [BOP], and probing‐pocket‐depth [PPD]) and serum interleukin‐1beta (IL‐1β) and matrix metalloproteinase‐9 (MMP‐9) levels in patients with and without coronary artery disease (CAD) than NSPT alone. The aim of this short‐term pilot study was to assess the effect of NSPT + Nd:YAG laser therapy on periodontal parameters and serum IL‐1β and MMP‐9 levels in patients with and without CAD.Study DesignA prospective randomized clinical study was conducted on 87 patients who were divided into two groups: Group‐1: 44 patients with CAD and periodontal disease (PD) and Group‐2: 43 patients with PD alone. Treatment‐wise, these individuals were randomly divided into two subgroups: (i) NSPT alone and (ii) NSPT + Nd:YAG laser therapy. Demographic information was collected using a self‐completed questionnaire. Periodontal parameters (PI, BOP, and PPD) and serum IL‐1β and MMP‐9 levels were measured at baseline and after 3 months of treatment. P‐values <0.05 were considered statistically significant.ResultsAt 3 months follow‐up, PI (P < 0.01), BOP (P < 0.01), PPD ≥ 4 mm (P < 0.01), and serum IL‐1β (P < 0.01) and MMP‐9 (P < 0.01) levels were significantly higher in patients treated with NSPT alone than those treated with NSPT + Nd:YAG laser therapy. Among patients that underwent NSPT + laser therapy in both groups, periodontal parameters and serum IL‐1β, and MMP‐9 levels were comparable at 3‐months follow‐up.ConclusionNSPT + Nd:YAG laser therapy may be more effective in reducing periodontal inflammation and serum IL‐1β and MMP‐9 levels in patients with and without CAD than NSPT alone. Lasers Surg. Med. 48:929–935, 2016. © 2016 Wiley Periodicals, Inc.
Cost‐utility analysis of deep brain stimulation surgery plus best medical therapy versus best medical therapy in patients with Parkinson's: Economic evaluation alongside the PD SURG trial
Authors: McIntosh Emma , Gray Alastair , Daniels Jane , Gill Steven , Ives Natalie , Jenkinson Crispin , Mitchell Rosalind , Pall Hardev , Patel Smitaa , Quinn Niall , Rick Caroline , Wheatley Keith , Williams Adrian ,   on behalf of The PD SURG Collaborators Group
Published: February 2016

ABSTRACTIntroductionWilliams and colleagues reported that DBS surgery for patients with advanced PD improves motor function and quality of life compared to best medical therapy alone at 1 year, but with surgery‐related side effects in a minority. This article reports on the economic evaluation alongside this trial.MethodsDetailed resource use and quality of life over 12 months after randomization was obtained from the trial reported by Williams and colleagues. Outcomes were measured using the EQ‐5D and quality‐adjusted life years calculated.ResultsYear 1 costs for surgery were significantly higher than in best medical therapy, at £19,069 compared to £9,813, a difference of £9,256 (95% confidence interval [CI]: £7,625, £10,887). There was a small, significant gain in utility at 1 year but a statistically insignificant gain of 0.02 quality‐adjusted life years (95% CI: −0.015, 0.05) in the surgical arm. The incremental cost per quality‐adjusted life year of surgery at 1 year was £468,528. Extrapolation reveals that after 5 years, this ratio is likely to reduce to £45,180, but subsequently rise to £70,537 at 10 years owing to the increased probability of battery replacements (and re‐replacements) beyond 5 years.ConclusionIn this patient group, DBS is not cost‐effective at 1 year. Extrapolation, however, reveals an increasing likelihood of cost‐effectiveness up to 5 years and reducing cost‐effectiveness between 5 and 10 years. These models are sensitive to assumptions about future costs and quality‐adjusted life years gained. © 2016 International Parkinson and Movement Disorder Society
High dietary cholesterol intake during lactation promotes development of fatty liver in offspring of mice
Authors: Tsuduki Tsuyoshi , Yamamoto Kazushi , Hatakeyama Yu , Sakamoto Yu 
Published: February 2016

ScopeWe have previously demonstrated in mice that a maternal high fat diet during lactation enhances the susceptibility of offspring to obesity and fatty liver. A causative molecule, however, is yet to be identified. Therefore, we examined the role of cholesterol, the dietary intake of which increases with consumption of a high fat diet. Excessive cholesterol intake is involved in the development of fatty liver, which in turn becomes a risk factor for metabolic syndrome, which includes obesity, insulin resistance, and dyslipidemia. However, our knowledge of the influences on offspring of excessive maternal cholesterol intake alone during pregnancy and lactation is limited. We examined how excessive maternal cholesterol intake during lactation influences susceptibility of the offspring to metabolic syndrome in mice.ResultsHigh cholesterol intake promoted triacylglycerol accumulation in the liver of offspring (p < 0.05), and elevated expression of molecules involved in hepatic lipoprotein influx was identified as the underlying mechanism.ConclusionThese findings demonstrate that excessive maternal cholesterol intake during lactation enhances the susceptibility of the offspring to development of fatty liver.
Reprogramming of defended body weight after Roux‐En‐Y gastric bypass surgery in diet‐induced obese mice
Authors: Hao Zheng , Mumphrey Michael B. , Townsend R. Leigh , Morrison Christopher D. , Münzberg Heike , Ye Jianping , Berthoud Hans‐Rudolf 
Published: February 2016

ObjectiveRoux‐en‐Y gastric bypass surgery (RYGB) results in sustained lowering of body weight in most patients, but the mechanisms involved are poorly understood. The aim of this study was to obtain support for the notion that reprogramming of defended body weight, rather than passive restriction of energy intake, is a fundamental mechanism of RYGB.MethodsMale C57BL6J mice reaching different degrees of obesity on a high‐fat diet either with ad libitum access or with caloric restriction (weight‐reduced) were subjected to RYGB.ResultsRYGB‐induced weight loss and fat mass loss were proportional to pre‐surgical levels, with moderately obese mice losing less body weight and fat compared with very obese mice. Remarkably, mice that were weight‐reduced to the level of chow controls before surgery immediately gained weight after surgery, exclusively accounted for by lean mass gain.ConclusionsThe results provide additional evidence for reprogramming of a new defended body weight as an important principle by which RYGB lastingly suppresses body weight. RYGB appears to selectively abolish defense of a higher fat mass level, while remaining sensitive to the defense of lean mass. The molecular and physiological mechanisms underlying this reprogramming remain to be elucidated.
Robust receding horizon parameterized control for multi‐class freeway networks: A tractable scenario‐based approach
Authors: Liu Shuai , Sadowska Anna , Frejo José Ramón D. , Núñez Alfredo , Camacho Eduardo F. , Hellendoorn Hans , De Schutter Bart 
Published: February 2016

SummaryIn this paper, we propose a tractable scenario‐based receding horizon parameterized control (RHPC) approach for freeway networks. In this approach, a scenario‐based min–max scheme is used to handle uncertainties. This scheme optimizes the worst case among a limited number of scenarios that are considered. The use of parameterized control laws allows us to reduce the computational burden of the robust control problem based on the multi‐class METANET model w.r.t. conventional model predictive control. To assess the performance of the proposed approach, a simulation experiment is implemented, in which scenario‐based RHPC is compared with nominal RHPC, standard control ignoring uncertainties, and standard control including uncertainties. Here, the standard control approaches refer to state feedback controllers (such as PI‐ALINEA for ramp metering). A queue override scheme is included for extra comparison. The results show that nominal RHPC approaches and standard control ignoring uncertainties may lead to high queue length constraint violations, and including a queue override scheme in standard control may not reduce queue length constraint violations to a low level. Including uncertainties in standard control approaches can obviously reduce queue length constraint violations, but the performance improvements are minor. For the given case study, scenario‐based RHPC performs best as it is capable of improving control performance without high queue length constraint violations. Copyright © 2016 John Wiley & Sons, Ltd.
A secure image encryption algorithm based on chaotic maps and SHA‐3
Authors: Ye Guodong , Huang Xiaoling 
Published: February 2016

AbstractIn this paper, a chaotic image encryption algorithm is suggested combining with double chaotic maps, SHA‐3 (Secure Hash Algorithm‐3), and auto‐updating system. To shuffle pixel positions, a matrix having same size of the plain‐image is generated dependent on the plain‐image in stage of permutation. Then, SHA‐3 is taken to calculate its hash values used to produce control parameter and initial condition of Logistic map. After that, total permutation is implemented for row and column to exchange pixels, where auto‐updating systems are established by different images acting like one‐time pad. Furthermore, 3D chaotic cat map is employed to enlarge key space in diffusion process. Permuted image is firstly divided into four sub‐blocks, which are queued randomly according to the key of Logistic map. The last sub‐block is picked out to calculate the hash values using SHA‐3, of which are assigned into three groups to update the initial conditions of 3D chaotic cat map performing like one‐time pad again. Current sub‐block is designed to influence next sub‐block in diffusion process. As a result, the proposed algorithm can resist efficiently the chosen‐plaintext and known‐plaintext attacks. Experimental results are also given to explain the high security of the proposed method. Copyright © 2016 John Wiley & Sons, Ltd.