bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change velocity underestimates climate change exposure in mountainous regions
Authors: Dobrowski Solomon Z. , Parks Sean A. 
Published: August 2016

AbstractClimate change velocity is a vector depiction of the rate of climate displacement used for assessing climate change impacts. Interpreting velocity requires an assumption that climate trajectory length is proportional to climate change exposure; longer paths suggest greater exposure. However, distance is an imperfect measure of exposure because it does not quantify the extent to which trajectories traverse areas of dissimilar climate. Here we calculate velocity and minimum cumulative exposure (MCE) in degrees Celsius along climate trajectories for North America. We find that velocity is weakly related to MCE; each metric identifies contrasting areas of vulnerability to climate change. Notably, velocity underestimates exposure in mountainous regions where climate trajectories traverse dissimilar climates, resulting in high MCE. In contrast, in flat regions velocity is high where MCE is low, as these areas have negligible climatic resistance to movement. Our results suggest that mountainous regions are more climatically isolated than previously reported.
Nested quantum annealing correction
Authors: Vinci Walter , Albash Tameem , Lidar Daniel A 
Published: August 2016

AbstractWe present a general error-correcting scheme for quantum annealing that allows for the encoding of a logical qubit into an arbitrarily large number of physical qubits. Given any Ising model optimization problem, the encoding replaces each logical qubit by a complete graph of degree C, representing the distance of the error-correcting code. A subsequent minor-embedding step then implements the encoding on the underlying hardware graph of the quantum annealer. We demonstrate experimentally that the performance of a D-Wave Two quantum annealing device improves as C grows. We show that the performance improvement can be interpreted as arising from an effective increase in the energy scale of the problem Hamiltonian or, equivalently, an effective reduction in the temperature at which the device operates. The number C thus allows us to control the amount of protection against thermal and control errors, and, in particular, to trade qubits for a lower effective temperature that scales as C−η, with η⩽2. This effective temperature reduction is an important step towards scalable quantum annealing.
Heterodyne mixing of millimetre electromagnetic waves and sub-THz sound in a semiconductor device
Authors: Heywood Sarah L. , Glavin Boris A. , Beardsley Ryan P. , Akimov Andrey V. , Carr Michael W. , Norman James , Norton Philip C. , Prime Brian , Priestley Nigel , Kent Anthony J. 
Published: August 2016

AbstractWe demonstrate heterodyne mixing of a 94 GHz millimetre wave photonic signal, supplied by a Gunn diode oscillator, with coherent acoustic waves of frequency ~100 GHz, generated by pulsed laser excitation of a semiconductor surface. The mixing takes place in a millimetre wave Schottky diode and the intermediate frequency electrical signal is in the 1–12 GHz range. The mixing process preserves all the spectral content in the acoustic signal that falls within the intermediate frequency bandwidth. Therefore this technique may find application in high-frequency acoustic spectroscopy measurements, exploiting the nanometre wavelength of sub-THz sound. The result also points the way to exploiting acoustoelectric effects in photonic devices working at sub-THz and THz frequencies, which could provide functionalities at these frequencies, e.g. acoustic wave filtering, that are currently in widespread use at lower (GHz) frequencies.
Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability
Authors: Shakeshaft Nicholas G. , Rimfeld Kaili , Schofield Kerry L. , Selzam Saskia , Malanchini Margherita , Rodic Maja , Kovas Yulia , Plomin Robert 
Published: August 2016

AbstractSpatial abilities–defined broadly as the capacity to manipulate mental representations of objects and the relations between them–have been studied widely, but with little agreement reached concerning their nature or structure. Two major putative spatial abilities are “mental rotation” (rotating mental models) and “visualisation” (complex manipulations, such as identifying objects from incomplete information), but inconsistent findings have been presented regarding their relationship to one another. Similarly inconsistent findings have been reported for the relationship between two- and three-dimensional stimuli. Behavioural genetic methods offer a largely untapped means to investigate such relationships. 1,265 twin pairs from the Twins Early Development Study completed the novel “Bricks” test battery, designed to tap these abilities in isolation. The results suggest substantial genetic influence unique to spatial ability as a whole, but indicate that dissociations between the more specific constructs (rotation and visualisation, in 2D and 3D) disappear when tested under identical conditions: they are highly correlated phenotypically, perfectly correlated genetically (indicating that the same genetic influences underpin performance) and are related similarly to other abilities. This has important implications for the structure of spatial ability, suggesting that the proliferation of apparent sub-domains may sometimes reflect idiosyncratic tasks rather than meaningful dissociations.
Defect visualization of Cu(InGa)(SeS)2 thin films using DLTS measurement
Authors: Heo Sung , Chung JaeGwan , Lee Hyung-Ik , Lee Junho , Park Jong-Bong , Cho Eunae , Kim KiHong , Kim Seong Heon , Park Gyeong Su , Lee Dongho , Lee Jaehan , Nam Junggyu , Yang JungYup , Lee Dongwha , Cho Hoon Young , Kang Hee Jae , Choi Pyung-Ho , Choi Byoung-Deog 
Published: August 2016

AbstractDefect depth profiles of Cu (In1−x,Gax)(Se1−ySy)2 (CIGSS) were measured as functions of pulse width and voltage via deep-level transient spectroscopy (DLTS). Four defects were observed, i.e., electron traps of ~0.2 eV at 140 K (E1 trap) and 0.47 eV at 300 K (E2 trap) and hole traps of ~0.1 eV at 100 K (H1 trap) and ~0.4 eV at 250 K (H2 trap). The open circuit voltage (VOC) deteriorated when the trap densities of E2 were increased. The energy band diagrams of CIGSS were also obtained using Auger electron spectroscopy (AES), X-ray photoelectron spectroscopy (XPS), and DLTS data. These results showed that the valence band was lowered at higher S content. In addition, it was found that the E2 defect influenced the VOC and could be interpreted as an extended defect. Defect depth profile images provided clear insight into the identification of defect state and density as a function of depth around the space charge region.
Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans
Authors: Root David H. , Wang Hui-Ling , Liu Bing , Barker David J. , Mód László , Szocsics Péter , Silva Afonso C. , Maglóczky Zsófia , Morales Marisela 
Published: August 2016

AbstractThe rodent ventral tegmental area (VTA) and substantia nigra pars compacta (SNC) contain dopamine neurons intermixed with glutamate neurons (expressing vesicular glutamate transporter 2; VGluT2), which play roles in reward and aversion. However, identifying the neuronal compositions of the VTA and SNC in higher mammals has remained challenging. Here, we revealed VGluT2 neurons within the VTA and SNC of nonhuman primates and humans by simultaneous detection of VGluT2 mRNA and tyrosine hydroxylase (TH; for identification of dopamine neurons). We found that several VTA subdivisions share similar cellular compositions in nonhuman primates and humans; their rostral linear nuclei have a high prevalence of VGluT2 neurons lacking TH; their paranigral and parabrachial pigmented nuclei have mostly TH neurons, and their parabrachial pigmented nuclei have dual VGluT2-TH neurons. Within nonhuman primates and humans SNC, the vast majority of neurons are TH neurons but VGluT2 neurons were detected in the pars lateralis subdivision. The demonstration that midbrain dopamine neurons are intermixed with glutamate or glutamate-dopamine neurons from rodents to humans offers new opportunities for translational studies towards analyzing the roles that each of these neurons play in human behavior and in midbrain-associated illnesses such as addiction, depression, schizophrenia, and Parkinson’s disease.
Dose-dependent and cell type-specific cell death and proliferation following in vitro exposure to radial extracorporeal shock waves
Authors: Hochstrasser Tanja , Frank Hans-Georg , Schmitz Christoph 
Published: August 2016

AbstractRadial extracorporeal shock wave (rESW) therapy is widely used in musculoskeletal disorders and wound repair. However, the mechanisms of action are still largely unknown. The current study compared the effects of rESWs on two cell types. Human fetal foreskin fibroblasts (HFFF2) and human placental choriocarcinoma cell line JEG-3 were exposed to 0, 100, 200, 500 or 5000 rESWs generated with a Swiss DolorClast device (2.5 bar, 1 Hz). FACS analysis immediately after rESW exposure showed that initially, rESWs rather induced mechanical cell destruction than regulated or programmed cell death. Cell damage was nearly negated by reducing cavitation. Furthermore, cell viability decreased progressively with higher numbers of rESWs. Exposure to rESWs had no impact on growth potential of JEG-3 cells, but dose-dependently increased growth potential of HFFF2 cells. Cultivation of cells that were initially exposed to sham-rESWs in conditioned media increased the growth potential of HFFF2 cells, nevertheless, an even stronger effect was achieved by direct exposure to rESWs. Additionally, cell cycle distribution analysis demonstrated a shift in proportion from G0/G1 to G2/M phase in HFFF2 cells, but not in JEG-3 cells. These data demonstrate that rESWs leads to initial and subsequent dose-dependent and cell type-specific effects in vitro.
HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2
Authors: Granato M. , Zompetta C. , Vescarelli E. , Rizzello C. , Cardi A. , Valia S. , Antonelli G. , Marchese C. , Torrisi M. R. , Faggioni A. , Cirone M. 
Published: August 2016

AbstractHepatitis C virus (HCV) infection is a leading cause of liver fibrosis, especially in developing countries. The process is characterized by the excess accumulation of ECM that may lead, over time, to hepatic cirrhosis, liver failure and also to hepatocarcinoma. The direct role of HCV in promoting fibroblasts trans-differentiation into myofibroblasts, the major fibrogenic cells, has not been fully clarified. In this study, we found that HCV derived from HCV-infected patients infected and directly induced the trans-differentiation of human primary fibroblasts into myofibroblasts, promoting fibrogenesis. This effect correlated with the activation of GLI2, one of the targets of Hedgehog signaling pathway previously reported to be involved in myofibroblast generation. Moreover, GLI2 activation by HCV correlated with a reduction of autophagy in fibroblasts, that may further promoted fibrosis. GLI2 inhibition by Gant 61 counteracted the pro-fibrotic effects and autophagy inhibition mediated by HCV, suggesting that targeting HH/GLI2 pathway might represent a promising strategy to reduce the HCV-induced fibrosis.
Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening
Authors: Zhang Hansi , Pluhackova Kristyna , Jiang Zhenyan , Böckmann Rainer A. 
Published: August 2016

AbstractSphingosine-1-phosphate (S1P) is a lysophospholipid mediator carried by the HDL-associated apoM protein in blood, regulating many physiological processes by activating the G protein-coupled S1P receptor in mammals. Despite the solved crystal structure of the apoM-S1P complex, the mechanism of S1P release from apoM as a part of the S1P pathway is unknown. Here, the dynamics of the wild type apoM-S1P complex as well as of mutants were investigated by means of atomistic molecular dynamics simulations. The potential of mean force for S1P unbinding from apoM reflected a large binding strength of more than 60 kJ/mol. This high unbinding free energy for S1P underlines the observed specificity of the physiological effects of S1P as it suggests that the spontaneous release of S1P from apoM is unlikely. Instead, S1P release and thus the control of this bioactive lipid probably requires the tight interaction with other molecules, e.g. with the S1P receptor. Mutations of specific S1P anchoring residues of apoM decreased the energetic barrier by up to 20 kJ/mol. Moreover, the ligand-free apoM protein is shown to adopt a more open upper hydrophilic binding pocket and to result in complete closure of the lower hydrophobic cavity, suggesting a mechanism for adjusting the gate for ligand access.
Stress Wave Isolation by Purely Mechanical Topological Phononic Crystals
Authors: Chaunsali Rajesh , Li Feng , Yang Jinkyu 
Published: August 2016

AbstractWe present an active, purely mechanical stress wave isolator that consists of short cylindrical particles arranged in a helical architecture. This phononic structure allows us to change inter-particle stiffness dynamically by controlling the contact angles of the cylinders. We use torsional travelling waves to control the contact angles, thereby imposing a desired spatio-temporal stiffness variation to the phononic crystal along the longitudinal direction. Such torsional excitation is a form of parametric pumping in the system, which results in the breakage of the time-reversal symmetry. We report that, in quasi-static sense, the system shows topologically non-trivial band-gaps. However, in a dynamic regime where the pumping effect is significant, these band-gaps become asymmetric with respect to the frequency and wavenumber domains in the dispersion relationship. By using numerical simulations, we show that such asymmetry has a direct correspondence to the topological invariant, i.e., Chern number, of the system. We propose that this asymmetry, accompanied by selective inter-band transition, can be utilized for directional isolation of the stress wave propagating along the phononic crystal.
A quantitative assessment of Arctic shipping in 2010–2014
Authors: Eguíluz Victor M. , Fernández-Gracia Juan , Irigoien Xabier , Duarte Carlos M. 
Published: August 2016

AbstractRapid loss of sea ice is opening up the Arctic Ocean to shipping, a practice that is forecasted to increase rapidly by 2050 when many models predict that the Arctic Ocean will largely be free of ice toward the end of summer. These forecasts carry considerable uncertainty because Arctic shipping was previously considered too sparse to allow for adequate validation. Here, we provide quantitative evidence that the extent of Arctic shipping in the period 2011–2014 is already significant and that it is concentrated (i) in the Norwegian and Barents Seas, and (ii) predominantly accessed via the Northeast and Northwest Passages. Thick ice along the forecasted direct trans-Arctic route was still present in 2014, preventing transit. Although Arctic shipping remains constrained by the extent of ice coverage, during every September, this coverage is at a minimum, allowing the highest levels of shipping activity. Access to Arctic resources, particularly fisheries, is the most important driver of Arctic shipping thus far.
Endoscopic detection of cancer with lensless radioluminescence imaging and machine vision
Authors: Türkcan Silvan , Naczynski Dominik J. , Nolley Rosalie , Sasportas Laura S. , Peehl Donna M. , Pratx Guillem 
Published: August 2016

AbstractComplete removal of residual tumor tissue during surgical resection improves patient outcomes. However, it is often difficult for surgeons to delineate the tumor beyond its visible boundary. This has led to the development of intraoperative detectors that can image radiotracers accumulated within tumors, thus facilitating the removal of residual tumor tissue during surgical procedures. We introduce a beta imaging system that converts the beta radiation from the radiotracer into photons close to the decay origin through a CdWO4 scintillator and does not use any optical elements. The signal is relayed onto an EMCCD chip through a wound imaging fiber. The sensitivity of the device allows imaging of activity down to 100 nCi and the system has a resolution of at least 500 μm with a field of view of 4.80 × 6.51 mm. Advances in handheld beta cameras have focused on hardware improvements, but we apply machine vision to the recorded images to extract more information. We automatically classify sample regions in human renal cancer tissue ex-vivo into tumor or benign tissue based on image features. Machine vision boosts the ability of our system to distinguish tumor from healthy tissue by a factor of 9 ± 3 and can be applied to other beta imaging probes.
Macromolecular crowding meets oxygen tension in human mesenchymal stem cell culture - A step closer to physiologically relevant in vitro organogenesis
Authors: Cigognini Daniela , Gaspar Diana , Kumar Pramod , Satyam Abhigyan , Alagesan Senthilkumar , Sanz-Nogués Clara , Griffin Matthew , O’Brien Timothy , Pandit Abhay , Zeugolis Dimitrios I. 
Published: August 2016

AbstractModular tissue engineering is based on the cells’ innate ability to create bottom-up supramolecular assemblies with efficiency and efficacy still unmatched by man-made devices. Although the regenerative potential of such tissue substitutes has been documented in preclinical and clinical setting, the prolonged culture time required to develop an implantable device is associated with phenotypic drift and/or cell senescence. Herein, we demonstrate that macromolecular crowding significantly enhances extracellular matrix deposition in human bone marrow mesenchymal stem cell culture at both 20% and 2% oxygen tension. Although hypoxia inducible factor - 1α was activated at 2% oxygen tension, increased extracellular matrix synthesis was not observed. The expression of surface markers and transcription factors was not affected as a function of oxygen tension and macromolecular crowding. The multilineage potential was also maintained, albeit adipogenic differentiation was significantly reduced in low oxygen tension cultures, chondrogenic differentiation was significantly increased in macromolecularly crowded cultures and osteogenic differentiation was not affected as a function of oxygen tension and macromolecular crowding. Collectively, these data pave the way for the development of bottom-up tissue equivalents based on physiologically relevant developmental processes.
Enhanced spin Hall effect of tunneling light in hyperbolic metamaterial waveguide
Authors: Tang Tingting , Li Chaoyang , Luo Li 
Published: August 2016

AbstractGiant enhancement of spin Hall effect of tunneling light (SHETL) is theoretically proposed in a frustrated total internal reflection (FTIR) structure with hyperbolic metamaterial (HMM). We calculate the transverse shift of right-circularly polarized light in a SiO2-air-HMM-air-SiO2 waveguide and analyze the physical mechanism of the enhanced SHETL. The HMM anisotropy can greatly increase the transverse shift of polarized light even though HMM loss might reduce it. Compared with transverse shift of transmitted light through a single HMM slab with ZnAlO/ZnO multilayer, the maximum transverse shift of tunneling light through a FTIR structure with identical HMM can be significantly enlarged by more than three times which reaches −38 μm without any amplification method.
Resistin reinforces interferon λ-3 to eliminate hepatitis C virus with fine-tuning from RETN single-nucleotide polymorphisms
Authors: Chang Ming-Ling , Liang Kung-Hao , Ku Cheng-Lung , Lo Chia-Chi , Cheng Ya-Ting , Hsu Chen-Ming , Yeh Chau-Ting , Chiu Cheng-Tang 
Published: August 2016

AbstractThe effect of resistin (RETN) on the response to anti-HCV therapy remains unclear. A prospective cohort study was performed using 655 consecutive HCV patients, of whom 513 had completed a course of interferon-based therapy. Multivariate and GEE analyses revealed four RETN single-nucleotide polymorphisms (SNPs), rs34861192, rs3219175, rs3745367 and rs1423096, to be synergistically associated with resistin levels. After adjusting for co-factors such as interferon λ-3 (IFNL3)-rs12979860, the resistin level and the hyper-resistinemic genotype at the 4 RETN SNPs were positively and negatively associated with a sustained virological response (SVR), respectively. RETN-rs3745367 was in linkage disequilibrium with IFNL3-rs12979860. Compared to non-SVR patients, SVR patients had higher levels of pre-therapy resistin, primarily originating from intrahepatic lymphocytes, stellate cells, Kupffer cells, hepatic progenitor cells and hepatocytes. This difference diminished over the course of therapy, as only SVR patients exhibited a 24-week post-therapy decrease in resistin. Both resistin and IFNL3 mRNAs were upregulated, but only resistin mRNA was upregulated by recombinant resistin in peripheral blood mononuclear cells with and without hyper-resistinemic genotypes of the 4 RETN SNPs, respectively. Fine-tuned by RETN SNPs, intrahepatic, multi-cellular resistin reinforced IFNL3 in eliminating HCV via immunomodulation to counteract pro-inflammation. These results encourage the development of novel resistin-targeted anti-viral agents.
The role of vision for navigation in the crown-of-thorns seastar, Acanthaster planci
Authors: Sigl Robert , Steibl Sebastian , Laforsch Christian 
Published: August 2016

AbstractCoral reefs all over the Indo-Pacific suffer from substantial damage caused by the crown-of-thorns seastar Acanthaster planci, a voracious predator that moves on and between reefs to seek out its coral prey. Chemoreception is thought to guide A. planci. As vision was recently introduced as another sense involved in seastar navigation, we investigated the potential role of vision for navigation in A. planci. We estimated the spatial resolution and visual field of the compound eye using histological sections and morphometric measurements. Field experiments in a semi-controlled environment revealed that vision in A. planci aids in finding reef structures at a distance of at least 5 m, whereas chemoreception seems to be effective only at very short distances. Hence, vision outweighs chemoreception at intermediate distances. A. planci might use vision to navigate between reef structures and to locate coral prey, therefore improving foraging efficiency, especially when multidirectional currents and omnipresent chemical cues on the reef hamper chemoreception.