bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations for the use of oral treprostinil in clinical practice: a Delphi consensus project pulmonary circulation
Authors: Rahaghi Franck F. , Feldman Jeremy P. , Allen Roblee P. , Tapson Victor , Safdar Zeenat , Balasubramanian Vijay P. , Shapiro Shelley , Mathier Michael A. , Elwing Jean M. , Chakinala Murali M. , White R. James 
Published: November 2016

Oral treprostinil was recently labeled for treatment of pulmonary arterial hypertension. Similar to the period immediately after parenteral treprostinil was approved, there is a significant knowledge gap for practicing physicians who might prescribe oral treprostinil. Despite its oral route of delivery, use of the drug is challenging because of the requirement for careful titration and management of drug‐related adverse effects. We aimed to create a consensus document combining available evidence with expert opinion to provide guidance for use of oral treprostinil. Following a methodology commonly used in business and social sciences (the ‘Delphi Process’), two investigators from the oral treprostinil (Freedom) studies created a series of statements based on available evidence and the package insert. The set of ‘best practice’ statements was circulated to nine other Freedom trial investigators. Their comments were incorporated into the document as new line items for further vote and comment. The subsequent document was put to vote line by line (scale of −5 to +5) and a final statement was drafted. Consensus recommendations include initial therapy with 0.125 mg for treatment naÿve patients, three times daily dosing, aggressive use of antidiarrheal medication, and a strong preference for use of the drug in combination with other approved PAH therapies. This process was particularly valuable in providing guidance for the management of adverse events (where essentially no data is available). The Delphi process was useful to codify investigator experience and subsequently develop investigator consensus about practical issues for physicians who may wish to prescribe oral treprostinil.
Final report on EUROMET key comparison EUROMET.M.D-K2 (EUROMET 627) "Comparison of density determinations of liquid samples"
Authors: Bettin Horst , Heinonen Martti , Gosset  , Zelenka n , Lorefice Salvatore , Hellerud Kristen , Durlik Hanna , Jordaan Werner , Field Ireen 
Published: November 2016

The results of the key comparison EUROMET 627 (EUROMET.M.D-K2) are presented. This project covered the density measurements of three liquids: dodecane, water and an oil of high viscosity measured at 15 °C, 20 °C and 40 °C. Seven European metrology laboratories and the South African laboratory CSIR-NML (now: NMISA) measured the densities at atmospheric pressure by hydrostatic weighing of solid density standards between 04 October 2001 and 18 December 2001. The stability and homogeneity of the liquids were investigated by the pilot laboratory PTB.
The results generally show good agreement among the participants. Only for the simple Mohr-Westphal balances do the uncertainties seem to be underestimated by the laboratories. Furthermore, the measurement of high-viscosity oil was difficult for some laboratories.
Nevertheless, the five laboratories PTB/DE, BNM/FR (now: LNE/FR), OMH/HU (now: MKEH/HU), IMGC/IT (now: INRIM/IT) and GUM/PL agree with each other for stated uncertainties of 0.05 kg/m3 or less. This satisfies the current needs of customers who wish to calibrate or check liquid density measuring instruments such as oscillation-type density meters.
No reference values were calculated since the subsequent CCM key comparison CCM.D-K2 had a different scope and the EUROMET 627 comparison was soon superseded by the EURAMET 1019 (EURAMET.M.D-K2) comparison.

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Report on the APMP.M.F-S1 supplementary comparison for 2 MN force
Authors: Ueda K , Hayashi T , Maejima H , Kumme R , Röske D , Seidel M 
Published: November 2016

This document describes the comparison scheme and reports the results of the APMP.M.F-S1 supplementary comparison for 2 MN Force, in which two force transducers of 2 MN capacity were used.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
PhagesDB: the actinobacteriophage database
Authors: Russell Daniel A , Hatfull Graham F 
Published: November 2016

Abstract
The Actinobacteriophage Database (PhagesDB) is a comprehensive, interactive, database-backed website that collects and shares information related to the discovery, characterization and genomics of viruses that infect Actinobacterial hosts. To date, more than 8000 bacteriophages—including over 1600 with sequenced genomes—have been entered into the database. PhagesDB plays a crucial role in organizing the discoveries of phage biologists around the world—including students in the SEA-PHAGES program—and has been cited in over 50 peer-reviewed articles.
Availability and Implementation: http://phagesdb.org/
Pulsation versus metallicism in Am stars as revealed by LAMOST and WASP
Authors: Smalley B. , Antoci V. , Holdsworth D. L. , Kurtz D. W. , Murphy S. J. , De Cat P. , Anderson D. R. , Catanzaro G. , Collier Cameron A. , Hellier C. , Maxted P. F. L. , Norton A. J. , Pollacco D. , Ripepi V. , West R. G. , Wheatley P. J. 
Published: November 2016

Abstract
We present the results of a study of a large sample of A and Am stars with spectral types from LAMOST and light curves from WASP. We find that, unlike normal A stars, δ Sct pulsations in Am stars are mostly confined to the effective temperature range 6900&lt;Teff&lt;7600 K. We find evidence that the incidence of pulsations in Am stars decreases with increasing metallicism (degree of chemical peculiarity). The maximum amplitude of the pulsations in Am stars does not appear to vary significantly with metallicism. The amplitude distributions of the principal pulsation frequencies for both A and Am stars appear very similar and agree with results obtained from Kepler photometry. We present evidence that suggests turbulent pressure is the main driving mechanism in pulsating Am stars, rather than the κ-mechanism, which is expected to be suppressed by gravitational settling in these stars.
Similar Risk Patterns After Cervical Screening in Two Large U.S. Populations
Authors: Gage Julia C. , Hunt William C. , Schiffman Mark , Katki Hormuzd A. , Cheung Li A. , Myers Orrin , Cuzick Jack , Wentzensen Nicolas , Kinney Walter , Castle Philip E. , Wheeler Cosette M. ,   for The New Mexico HPV Pap Registry Steering Committee
Published: November 2016

OBJECTIVE:
To compare the risks of histologic high-grade cervical intraepithelial neoplasia (CIN) or worse after different cervical cancer screening test results between two of the largest U.S. clinical practice research data sets.

METHODS:
The New Mexico Human Papillomavirus (HPV) Pap Registry is a statewide registry representing a diverse population experiencing varied clinical practice delivery. Kaiser Permanente Northern California is a large integrated health care delivery system practicing routine HPV cotesting since 2003. In this retrospective cohort study, a logistic-Weibull survival model was used to estimate and compare the cumulative 3- and 5-year risks of histologic CIN 3 or worse among women aged 21–64 years screened in 2007–2011 in the New Mexico HPV Pap Registry and 2003–2013 in Kaiser Permanente Northern California. Results were stratified by age and baseline screening result: negative cytology, atypical squamous cells of undetermined significance (ASC-US) (with or without HPV triage), low-grade squamous intraepithelial lesion, and high-grade squamous intraepithelial lesion.

RESULTS:
There were 453,618 women in the New Mexico HPV Pap Registry and 1,307,528 women at Kaiser Permanente Northern California. The 5-year CIN 3 or worse risks were similar within screening results across populations: cytology negative (0.52% and 0.30%, respectively, P<.001), HPV-negative and ASC-US (0.72% and 0.49%, respectively, P=.5), ASC-US (3.4% and 3.4%, respectively, P=.8), HPV-positive and ASC-US (7.7% and 7.1%, respectively, P=.3), low-grade squamous intraepithelial lesion (6.5% and 5.4%, respectively, P=.009), and high-grade squamous intraepithelial lesion (53.1% and 50.4%, respectively, P=.2). Cervical intraepithelial neoplasia grade 2 or worse risks and 3-year risks had similar trends across populations. Age-stratified analyses showed more variability, especially among women aged younger than 30 years, but patterns of risk stratification were comparable.

CONCLUSION:
Current U.S. cervical screening and management recommendations are based on comparative risks of histologic high-grade CIN after screening test results. The similar results from these two large cohorts from different real-life clinical practice settings support risk-based management thresholds across U.S. clinical populations and practice settings.
Risk Factors and Outcomes for Conversion to Laparotomy of Laparoscopic Hysterectomy in Benign Gynecology
Authors: Lim Courtney S. , Mowers Erika L. , Mahnert Nichole , Skinner Bethany D. , Kamdar Neil , Morgan Daniel M. , As-Sanie Sawsan 
Published: November 2016

OBJECTIVE:
To estimate the incidence and factors for conversion to laparotomy in women scheduled for laparoscopic hysterectomy for benign gynecologic indications and to examine the effect of conversion on patient outcomes.

METHODS:
A retrospective cohort study of a Michigan multicenter prospective database was abstracted from January 1, 2013, through July 2, 2014. Participants were collected from an all-payer quality and safety database maintained by the Michigan Surgical Quality Collaborative. Women with a preoperative indication of cancer or obstetric indications were excluded. A logistic regression model was used to calculate odds of conversion using patient preoperative and intraoperative attributes.

RESULTS:
During the study period, 6,992 women underwent an attempted laparoscopic hysterectomy with 3.93% (n=275) converted to laparotomy. After adjusting for socioeconomic differences, hysterectomy indication, and intraoperative factors, there were decreased odds of conversion to laparotomy with use of robotic-assisted laparoscopy compared with traditional laparoscopy (adjusted odds ratio [OR] 0.14, 95% confidence interval [CI] 0.07–0.25) with a predicted risk of conversion of 0.8% compared with 5.4% (P<.001). High-volume surgeons were less likely to convert to laparotomy compared with low- and medium-volume surgeons (adjusted OR 0.66, 95% CI 0.47–0.92) with a predicted risk of conversion of 1.4% compared with 2.25% (P=.015). Conversion was associated with moderate or severe adhesive disease and increasing specimen weight. Conversion was associated with increased rates of surgical site infection, blood transfusion, severe sepsis, and reoperation.

CONCLUSION:
This analysis demonstrates that conversion to laparotomy is associated with increased odds of postoperative morbidity, and robotic assistance and surgeon volume are strongly associated with decreased odds of conversion.
Intraoperative Cystoscopic Evaluation of Ureteral Patency
Authors: Espaillat-Rijo Luis , Siff Lauren , Alas Alexandriah N. , Chadi Sami A. , Zimberg Stephen , Vaish Sneha , Davila G. Willy , Barber Matthew , Hurtado Eric A. 
Published: November 2016

OBJECTIVE:
To compare different modalities to aid in the evaluation of intraoperative ureteral patency on cystoscopy in the postindigo carmine era.

METHODS:
In a randomized controlled trial, participants undergoing pelvic surgery were randomized into one of four groups: saline distention (control), 10% dextrose distention, oral phenazopyridine, or intravenous sodium fluorescein. Our primary outcome was visibility of the ureteral jets. Secondary outcomes included surgeon satisfaction; adverse reactions including allergies, urinary tract infections, urinary retention, cystoscopy times, and ureteral obstruction; and delayed diagnosis. Participants were followed for 6 weeks. A sample size of 176 participants was planned to demonstrate a 30% difference in the visibility scale. All analyses were performed in an intention-to-treat fashion.

RESULTS:
From February 25, 2015, through August 2015, 176 participants were enrolled; 174 completed the trial, and two did not undergo intervention. Forty-four participants were included in the phenazopyridine, dextrose, saline, and sodium fluorescein groups. Sodium fluorescein and 10% dextrose resulted in significantly improved visibility and satisfaction when compared with the control group (P<.001 and P=.004, respectively). Dextrose provided the highest satisfaction and phenazopyridine provided lowest, but visibility was not statistically different between the two groups (P=.101). Three ureteral obstructions were identified intraoperatively and none in the postoperative period. Mean total cystoscopy time varied between 4.0 and 4.8 minutes and postoperative urinary retention rate was 50% across all groups. Overall urinary tract infection rate was 24.1%, which was similar between interventions. There were no related adverse events.

CONCLUSION:
Compared with the control, 10% dextrose and sodium fluorescein resulted in improved visibility and provided significantly more satisfaction in the evaluation for ureteral patency with no considerable increase in operative time or morbidity.

CLINICAL TRIAL REGISTRATION:
ClinicalTrials.gov, https://clinicaltrials.gov, NCT02476448.
Raspberry Leaf and Hypoglycemia in Gestational Diabetes Mellitus
Authors: Cheang Kai I. , Nguyen Thanh T. , Karjane Nicole W. , Salley Kelsey E. S. 
Published: November 2016

BACKGROUND:
Raspberry leaf is commonly consumed by pregnant women. Hypoglycemic effects have been documented with other species within the plant family. Whether raspberry leaf affects glycemic control in gestational diabetes mellitus (GDM) is unknown.

CASE:
A 38-year-old nulliparous woman with GDM developed hypoglycemia requiring lowered insulin dose after consuming raspberry leaf tea at 32 weeks of gestation. The temporal relationship was confirmed by the patient's self-withdrawal and reintroduction of the herb. Fetal surveillance and growth were reassuring. A cesarean delivery was performed at 39 weeks of gestation. The neonate did not experience hypoglycemia or other complications. Placental biopsy revealed normal findings.

CONCLUSION:
Consumption of raspberry leaf may lead to reduced insulin requirements in GDM. Women with GDM should be cautioned about its use and their glucose levels more closely monitored.
Relationship Between Excessive Gestational Weight Gain and Neonatal Adiposity in Women With Mild Gestational Diabetes Mellitus
Authors: Blackwell Sean C. , Landon Mark B. , Mele Lisa , Reddy Uma M. , Casey Brian M. , Wapner Ronald J. , Varner Michael W. , Rouse Dwight J. , Thorp John M. , Sciscione Anthony , Catalano Patrick , Saade George , Caritis Steve N. , Sorokin Yoram , Grobman William A. ,   for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network
Published: November 2016

OBJECTIVE:
To evaluate the relationships among excessive gestational weight gain, neonatal adiposity, and adverse obstetric outcomes in women with mild gestational diabetes mellitus.

METHODS:
This is a secondary analysis of a multicenter randomized clinical trial of women with mild gestational diabetes mellitus. Based on self-reported prepregnancy body weight, gestational weight gain was categorized as excessive if it was greater than 2009 Institute of Medicine guidelines. Maternal outcomes and neonatal anthropomorphic characteristics were compared between women with excessive weight gain and those without excessive weight gain. Multiple linear and logistic regression analyses were performed to adjust for confounding factors.

RESULTS:
We studied 841 women who participated in the main trial and had prepregnancy body mass index (BMI) and delivery information available (n=431 treatment group, n=410 no treatment). After adjustment for factors including treatment and prepregnancy BMI, excessive weight gain remained associated with large for gestational age (adjusted odds ratio [OR] 2.94, 95% confidence interval [CI] 1.81–4.93), birth weight greater than 4,000 g (adjusted OR 2.56, 95% CI 1.54–4.40), preeclampsia (adjusted OR 2.96, 95% CI 1.35–7.03), and cesarean delivery for labor arrest (adjusted OR 2.37, 95% CI 1.30–4.44). In addition, excessive weight gain was independently associated with increased total neonatal fat (P<.001) and birth weight (P<.001).

CONCLUSION:
In women with both treated and untreated mild gestational diabetes mellitus, excessive gestational weight gain was independently associated with both greater birth weight and adiposity.
Imaging for Polyps and Leiomyomas in Women With Abnormal Uterine Bleeding
Authors: Maheux-Lacroix Sarah , Li Fiona , Laberge Philippe Y. , Abbott Jason 
Published: November 2016

OBJECTIVE:To evaluate the accuracy of saline infusion sonohysterography in comparison with transvaginal ultrasonography for diagnosing polyps and submucosal leiomyomas in women with abnormal uterine bleeding.DATA SOURCES:We searched the databases MEDLINE, EMBASE, CENTRAL, and ClinicalTrials.gov as well as citations and reference lists to the end of November 2015.METHODS OF STUDY SELECTION:Two authors screened 5,347 citations for eligibility. We included randomized controlled trials or prospective cohort studies published in English, assessing the accuracy of saline infusion sonohysterography and transvaginal ultrasonography for diagnosing polyps and submucosal leiomyomas in women with abnormal uterine bleeding. We considered studies using histopathologic specimens obtained at either hysteroscopy or hysterectomy as criterion standard.TABULATION, INTEGRATION, AND RESULTS:Twenty-five studies were eligible. Two authors extracted data and assessed the quality of included studies. Bivariate random-effects models were used to compare the different tests and evaluate sources of heterogeneity. Saline infusion sonohysterography was superior to transvaginal ultrasonography with pooled sensitivity and specificity of 0.92 and 0.89 compared with 0.64 and 0.90, respectively (P<.001). Transvaginal ultrasound sensitivity for diagnosing polyps was particularly low (0.51). Saline infusion sonohysterography was also compared with hysteroscopy in seven studies and had similar sensitivity but inferior specificity (0.93 and 0.83 compared with 0.95 and 0.90, respectively,P=.007). All three procedures were well-tolerated by women. Saline infusion sonohysterography was successfully completed in 95% of women. Technical variations such as the use of balloon catheters were not found to affect diagnostic accuracy.CONCLUSION:Transvaginal ultrasonography lacks sensitivity to be used alone to exclude the presence of polyps and leiomyomas in women with abnormal uterine bleeding. Although less specific than hysteroscopy, saline infusion sonohysterography offers a similar detection rate and permits concomitant visualization of the ovaries and myometrium. Cost, convenience, and tolerability of different imaging techniques require further evaluation.SYSTEMATIC REVIEW REGISTRATION:PROSPERO International prospective register of systematic reviews, http://www.crd.york.ac.uk/PROSPERO, CRD42016034005.
Fistula-Associated Anorectal Cancer in the Setting of Crohn’s Disease
Authors: Shwaartz Chaya , Munger Jordan A. , Deliz Juan R. , Bornstein Joseph E. , Gorfine Stephan R. , Chessin David B. , Popowich Daniel A. , Bauer Joel J. 
Published: November 2016

BACKGROUND:
Cancer arising from perianal fistulas in patients with Crohn’s disease is rare. There are only a small series of articles that describe sporadic cases of perianal cancer in Crohn’s disease fistulas. Therefore, there are no clear guidelines on how to appropriately screen patients at risk and choose proper management.

OBJECTIVE:
The purpose of this study was to describe patients diagnosed with cancer in perianal fistulas in the setting of Crohn’s disease.

DESIGN:
The study involved an institutional review board–approved retrospective review of medical charts of patients with perianal Crohn’s disease. The data extracted from patient charts included demographic and clinical characteristics.

SETTINGS:
Patients seen at the Mount Sinai Medical Center were included.

PATIENTS:
We identified patients who were diagnosed with perianal cancer in biopsies of fistula tracts.

MAIN OUTCOME MEASURES:
We observed the number of patients with Crohn's disease who had fistulas, cancer in fistula tract, and time to diagnosis.

RESULTS:
The charts of 2382 patients with fistulizing perianal Crohn’s disease were reviewed. Cancer in a fistula tract was diagnosed in 19 (0.79%) of these patients, 9 with squamous-cell carcinoma and 10 with adenocarcinoma. The majority of the 19 patients (68%) had symptoms typical of perianal fistula. The mean time from diagnosis of Crohn’s disease to fistula diagnosis and from fistula diagnosis to cancer diagnosis was 19.4 and 6.0 years. In 5 patients (26%), cancer was not diagnosed in the first biopsy obtained from the fistula tract.

LIMITATIONS:
This is a retrospective chart review of a rare outcome; the results may not be generalizable.

CONCLUSIONS:
Routine biopsies of long-standing fistula tracts in patients with Crohn’s disease should be strongly considered and may yield an earlier diagnosis of cancer in the fistula tracts.
Predictive Neuroimaging Markers of Psychotherapy Response: A Systematic Review
Authors: Chakrabarty Trisha , Ogrodniczuk John , Hadjipavlou George 
Published: November 2016

Introduction
Predictive neuroimaging markers of treatment response are increasingly sought in order to inform the treatment of major depressive and anxiety disorders. We review the existing literature regarding candidate predictive neuroimaging markers of psychotherapy response and assess their potential clinical utility.

Methods
We searched Embase, PsycINFO, and PubMed up to October 2014 for studies correlating pretreatment neuroimaging parameters with psychotherapy response in major depressive and anxiety disorders. Our search yielded 40 eligible studies.

Results
The anterior cingulate cortex, amygdala, and anterior insula emerged as potential markers in major depressive disorder and some anxiety disorders. Results across studies displayed a large degree of variability, however, and to date the findings have not been systematically validated in independent clinical cohorts and have not been shown capable of distinguishing between medication and psychotherapy responders. Also limited is the examination of how neuroimaging compares or might add to other prognostic clinical variables.

Conclusion
While the extant data suggest avenues of further investigation, we are still far from being able to use these markers clinically. Future studies need to focus on longitudinal testing of potential markers, determining their prescriptive value and examining how they might be integrated with clinical factors.