bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunophenotypic aberrancies in acute lymphoblastic leukemia from 282 Iraqi patients
Authors: Jalal S. D. , Al‐Allawi N. A. S. , Al Doski A. A. S. 
Published: July 2017

AbstractIntroductionThe identification of aberrancies in leukemia‐associated immunophenotype (LAIP) of acute lymphoblastic leukemia (ALL) is quite important in the assessment of minimal residual disease (MRD). This study, the first from Iraq, aimed to assess the frequency and patterns of LAIP among Iraqi patients with ALL, to establish future strategies for evaluating MRD.MethodsA total of 282 newly diagnosed Iraqi ALL cases were analyzed with six‐parameter flow cytometry using a panel of 29 monoclonal antibodies.ResultsImmunological subtyping revealed that 85.5% of cases were B‐ALL and the remainder T‐ALL. LAIP was detected in 97.1% of B‐ALL, and in 26.8% of T‐ALL. The asynchronous maturation‐associated antigen patterns in B‐ALL were CD10strong+/TdTdim+, CD38dim+/CD34+, CD10dim+/CD34+, CD10strong/CD20strong+, CD20strong+/CD34+, and CD45dim+/CD20strong+ in 84.6%, while the cross‐lineage myeloid expression was seen in 81.3% and aberrant T‐cell antigen expression in 6.2%. For T‐ALL, asynchronous maturation‐associated antigen patterns included the following: CD1a+/CD5+/sCD3+ and CD34+/sCD3+ in 12.2%. Myeloid and B‐cell antigen expression were each identified in 7.3% of T‐ALL. No significant differences in LAIP were found between children and adults.ConclusionThe high rates and the patterns of LAIP particularly in Iraqi B‐ALL patients may allow the development of more cost‐effective strategies for MRD monitoring.
Cross, Contestation and Consummation: An Engagement with Ted Peters’ God – The World's Future
Authors: Hinlicky Paul R. 
Published: July 2017

AbstractThe third edition of Peters’ systematic theology provides an opportunity to assess his contextual theology, descended from Tillich's ‘method of correlation’, from the perspective of my own textual theology, descended from Karl Barth's revelation theology, on the common ground of a shared Trinitarianism and positive retrieval of the twentieth‐century's rediscovery of the New Testament eschatology. The article affirms Peters’ sharply focused cognitive claim to truth about God as the world's future, but asks a series of questions about how this claim is actually sustained in Peters’ capacious work. It concludes with the ‘apocalyptic’ judgement that Peters’ ‘progressive’ method is not fully adequate to the challenge of our present spiritual situation.
When Father Steps Forward and Mother Steps Back: The Moderating Role of Simultaneity in Parents' Coparenting Behaviors in the Development of Anxiety in 4‐ to 30‐Month‐Olds
Authors: Metz Marijke , Colonnesi Cristina , Majdandžić Mirjana , Bögels Susan M. 
Published: July 2017

Infant negative affectivity predicts child anxiety. Coparenting might influence the development of anxiety by weakening this association in the case of supportive coparenting, or by strengthening this association in the case of undermining coparenting. Parents can display coparenting behaviors simultaneously (both parents being supportive or undermining), or divergently (only one parent being supportive or undermining). In our longitudinal study, we investigated whether coparenting moderated the relation between infant negative affectivity at 4 months and child anxiety symptoms 2 years later. Hundred‐sixteen couples dressed up their firstborn infants in a clothes‐changing task. We coded cooperative, mutual, neutral, and competitive coparenting behaviors. Both parents rated infant negative affectivity and child anxiety symptoms. Infant negative affectivity significantly predicted child anxiety. This association was moderated by parents' divergent cooperative coparenting: It was stronger when mothers were cooperative while fathers were neutral, and weaker when fathers were cooperative while mothers were neutral. When fathers step forward (i.e., being cooperative) and mothers step back (i.e., leaving space), they may protect their at‐risk child from developing anxiety.
Managerial ability and bank‐loan pricing
Authors: De Franco Gus , Hope Ole‐Kristian , Lu Haihao 
Published: July 2017

AbstractThis paper examines the impact of borrowers’ managerial ability on lenders’ bank‐loan pricing and the channels through which managerial ability affects bank‐loan pricing. Using a large sample of US bank loans, we provide evidence that higher managerial ability is associated with lower bank‐loan prices. This effect is stronger in firms with high information risk, suggesting that an important channel for managerial ability to affect bank‐loan pricing is through improved financial disclosure to mitigate information asymmetry. The relationship is also stronger for firms with weak business fundamentals, implying that another channel is through improved business performance. Of these two mechanisms, path analysis suggests that the business‐fundamentals mechanism is the more important channel through which managerial ability affects bank‐loan pricing.
Hepatitis C virus and proprotein convertase subtilisin/kexin type 9: a detrimental interaction to increase viral infectivity and disrupt lipid metabolism
Authors: Pirro Matteo , Bianconi Vanessa , Francisci Daniela , Schiaroli Elisabetta , Bagaglia Francesco , Sahebkar Amirhossein , Baldelli Franco 
Published: July 2017

AbstractFrom viral binding to the hepatocyte surface to extracellular virion release, the replication cycle of the hepatitis C virus (HCV) intersects at various levels with lipid metabolism; this leads to a derangement of the lipid profile and to increased viral infectivity. Accumulating evidence supports the crucial regulatory role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipoprotein metabolism. Notably, a complex interaction between HCV and PCSK9 has been documented. Indeed, either increased or reduced circulating PCSK9 levels have been observed in HCV patients; this discrepancy might be related to several confounders, including HCV genotype, human immunodeficiency virus (HIV) coinfection and the ambiguous HCV‐mediated influence on PCSK9 transcription factors. On the other hand, PCSK9 may itself influence HCV infectivity, inasmuch as the expression of different hepatocyte surface entry proteins and receptors is regulated by PCSK9. The aim of this review is to summarize the current evidence about the complex interaction between HCV and liver lipoprotein metabolism, with a specific focus on PCSK9. The underlying assumption of this review is that the interconnections between HCV and PCSK9 may be central to explain viral infectivity.
Plastic deformation mechanisms in a new Ni‐base single crystal superalloy at room temperature
Authors: ZHANG P. , YUAN Y. , GAO Z. , LI B. , YANG G. , SONG X. 
Published: July 2017

SummaryThe evolution of dislocation configurations in a new Ni‐base single crystal superalloy, M4706, during tensile deformation at room temperature is characterised by transmission electron microscopy. Experimental results show that contrary to previous reports, numerous isolated superlattice stacking faults and extended stacking faults are formed in the slightly deformed specimens with and without tertiary γ′ precipitates. Meanwhile, it is also found that as the plastic deformation proceeds, the dominant deformation mechanism changes from stacking fault shearing to antiphase boundary shearing. Finally, based on experimental observations, the reasons for the formation of these faults and the transition in the deformation mechanism are discussed.
A meta‐ethnographic synthesis of midwives’ and nurses’ experiences of adverse labour and birth events
Authors: Elmir Rakime , Pangas Jackie , Dahlen Hannah , Schmied Virginia 
Published: July 2017

IntroductionHealth professionals are frequently exposed to traumatic events due to the nature of their work. While traumatic and adverse labour and birth events experienced by women are well researched, less attention has been given to midwives’ and nurses’ experiences of these events and the impact it has on their lives.Aims and objectivesTo undertake a meta‐ethnographic study of midwives’ and nurses’ experiences of adverse labour and birth events.MethodsScopus, CINHAL PLUS, MEDLINE and PUBMED databases were searched using subject headings and keywords. The search was limited to papers published in peer‐reviewed journals from 2004–October 2016. Quality appraisal was undertaken using the Critical Appraisal Skills Programme tool.Inclusion criteriaPapers had to be qualitative or have a substantial qualitative component. Studies were included if they primarily focused on midwives’ or nurses’ perspectives or experiences of complicated, traumatic or adverse labour and birth events.Analytic strategyA meta‐ethnographic approach was used incorporating methods of reciprocal translation guided by the work of Noblit and Hare (1988, Meta‐Ethnography: Synthesizing qualitative studies (Vol. 11). Newbury Park: Sage publications).FindingsEleven qualitative studies were included in the final sample. Four major themes were (i) feeling the chaos; (ii) powerless, responsible and a failure; (iii) “It adds another scar to my soul”; and (iv) finding a way to deal with it.ConclusionMidwives and nurses feel relatively unprepared when faced with a real‐life labour and birth emergency event. While many of the midwives and nurses were traumatised by the experience, some were able to view their encounter as an opportunity to develop their emergency response skills.Relevance to clinical practiceWitnessing and being involved in a complicated or adverse labour and birth event can be traumatic for nurses and midwives. Organisational and collegial support needs to be available to enable these health professionals to talk about their feelings and concerns.
“Promoting continuity of care”—Specialist nurses’ role experiences in gynaecological oncology: A qualitative study
Authors: Kobleder Andrea , Mayer Hanna , Gehrig Larissa , Senn Beate 
Published: July 2017

Aims and objectivesTo investigate the experiences of specialist nurses in Switzerland concerning their role of caring for women with gynaecological cancer.BackgroundWomen with gynaecological cancer often face complex situations, which require an integrative and quality‐assured approach by the healthcare system. Specialist nurses can play an important role in supporting these patients. However, in countries where the role of specialist nurses is at a developmental stage, their role lacks clarity.DesignA qualitative descriptive design was chosen to gain insights into experiences of specialist nurses who care for women with gynaecological cancer.MethodsWe conducted three focus groups with 12 specialist nurses to access their experiences with regard to their role. Thematic qualitative text analysis was used to interpret the results.ResultsDivided into six main themes, the study results describe specialist nurses’ (1) current and (2) aspired role. (A) Counselling, (B) guidance, (C) key contact person and (D) team support are relevant themes in their current role. The themes (E) provision of resources and (F) extended knowledge are relevant to their aspired role. Within their current and aspired roles, the specialist nurses’ scope of practice is defined as “promoting continuity of care.”ConclusionsThe results indicate aspects of specialist nurses’ current and aspired roles. Detailed role descriptions and legal requirements are necessary to further support nurses towards an extended and specialised practice. In the context of gynaecological cancer survivors, services should be developed, where specialist nurses can play an important role in providing continuous care.Relevance to clinical practiceTo support implementation of specialist nursing in clinical practice, resources have to be mobilised and role descriptions should be provided. By creating an appropriate framework, the specialist nurse can turn into an important support for women with gynaecological cancer, in addition to current healthcare services.
Gravitropism interferes with hydrotropism via counteracting auxin dynamics in cucumber roots: clinorotation and spaceflight experiments
Authors: Morohashi Keita , Okamoto Miki , Yamazaki Chiaki , Fujii Nobuharu , Miyazawa Yutaka , Kamada Motoshi , Kasahara Haruo , Osada Ikuko , Shimazu Toru , Fusejima Yasuo , Higashibata Akira , Yamazaki Takashi , Ishioka Noriaki , Kobayashi Akie , Takahashi Hideyuki 
Published: July 2017

Summary

Roots of land plants show gravitropism and hydrotropism in response to gravity and moisture gradients, respectively, for controlling their growth orientation. Gravitropism interferes with hydrotropism, although the mechanistic aspects are poorly understood.

Here, we differentiated hydrotropism from gravitropism in cucumber roots by conducting clinorotation and spaceflight experiments. We also compared mechanisms regulating hydrotropism and auxin‐regulated gravitropism.

Clinorotated or microgravity (μG)‐grown cucumber seedling roots hydrotropically bent toward wet substrate in the presence of moisture gradients, but they grew straight in the direction of normal gravitational force at the Earth's surface (1G) on the ground or centrifuge‐generated 1G in space. The roots appeared to become hydrotropically more sensitive to moisture gradients under μG conditions in space. Auxin transport inhibitors significantly reduced the hydrotropic response of clinorotated seedling roots. The auxin efflux protein CsPIN5 was differentially expressed in roots of both clinorotated and μG‐grown seedlings; with higher expression in the high‐humidity (concave) side than the low‐humidity (convex) side of hydrotropically responding roots.

Our results suggest that roots become hydrotropically sensitive in μG, and CsPIN5‐mediated auxin transport has an important role in inducing root hydrotropism. Thus, hydrotropic and gravitropic responses in cucumber roots may compete via differential auxin dynamics established in response to moisture gradients and gravity.
UV‐B irradiation differentially regulates terpene synthases and terpene content of peach
Authors: Liu Hongru , Cao Xiangmei , Liu Xiaohong , Xin Rui , Wang Jiaojiao , Gao Jie , Wu Boping , Gao Liuxiao , Xu Changjie , Zhang Bo , Grierson Donald , Chen Kunsong 
Published: July 2017

AbstractPlants generate protective molecules in response to ultraviolet (UV) light. In laboratory experiments, 48 h UV‐B irradiation of peach fruits and leaves reduced the flavour‐related monoterpene linalool by 60%. No isoprene was detected, but other terpenoids increased significantly, including a threefold accumulation of the sesquiterpene (E,E)‐α‐farnesene, which was also increased by jasmonic acid treatment. RNA sequencing revealed altered transcript levels for two terpene synthases (TPSs): PpTPS1, a TPS‐g subfamily member, decreased by 86% and PpTPS2, a TPS‐b subfamily member, increased 80‐fold. Heterologous expression in Escherichia coli and transient overexpression in tobacco and peach fruits showed PpTPS1 was localized in plastids and associated with production of linalool, while PpTPS2 was responsible for (E,E)‐α‐farnesene biosynthesis in the cytoplasm. Candidate regulatory genes for these responses were identified. Commercial peach production in Asia involves fruit bagging to maintain marketable yield and quality. TPS gene expression and volatile terpenoid production in field experiments, using bags transmitting high UV‐B radiation, showed similar effects on peach volatiles to those from laboratory experiments. Bags transmitting less UV‐B light ameliorated the reduction in the flavour volatile linalool, indicating that flavour components of peach fruits can be modulated by selecting an appropriate source of environmental screening material.
Treatment evaluation using lung sound analysis in asthmatic children
Authors: Habukawa Chizu , Murakami Katsumi , Endoh Mitsuru , Horii Noriaki , Nagasaka Yukio 
Published: July 2017

ABSTRACT
Background and objectiveNon‐invasive assessment of treatment and prediction of attacks in asthmatic children do not yet exist. Lung sound analysis can non‐invasively evaluate airway obstruction. We used a recently developed technology for analysing lung sounds using ic700 (index of the chest wall at 700 Hz, sound intensity at 700 Hz) to evaluate response to inhaled corticosteroid (ICS) in asthmatic children.MethodSeventy asthmatic children, including infants, underwent lung sound recording in the asymptomatic state prior to and 1, 2, 4, 6 and 8 weeks after ICS treatment, and asthma control was assessed at 10 weeks. The ic700 scores at 4, 6 and 8 weeks were compared with the presence of attack during the following 2 weeks. Subjects were divided into uncontrolled and well‐controlled groups.ResultsThe mean ic700 scores of all subjects significantly reduced after 8 weeks of treatment. The mean scores of the uncontrolled group were significantly higher than those of the well‐controlled group at 4, 6 and 8 weeks after starting treatment. The ic700 cut‐off value for predicting asthma attacks within 2 weeks following the evaluation was set at 0.0. After 6 weeks of treatment, the area under the curve was 0.92 ± 0.04; the sensitivity, specificity and positive and negative predictive values were 83%, 88% and 88% and 84%, respectively. Similar results were observed at 4 and 8 weeks.ConclusionThe ic700 score is useful in assessing the effects of ICS treatment, predicting attack symptoms and identifying asymptomatic asthmatic children at a high risk for asthma attack.
Multifocal septic arthritis, gluteal abscess and spondylodiscitis byStreptococcus dysgalactiaesubspeciesequisimilisafter an intramuscular injection
Authors: Pocinho Rita Marques , Antunes Liliana , Pires Pedro , Baptista Isabel 
Published: July 2017

We present the case of a 63-year-old man, admitted for hand cellulitis and acute kidney injury. AStreptococcus dysgalactiaesubspequisimilis(SDSE) was isolated in blood cultures and despite directed intravenous antibiotherapy, the patient evolved unfavourably, with dorsolumbar spondylodiscitis, multifocal septic arthritis and abscesses. CT also showed densification of the gluteal muscles, multiple air bubbles in the psoas, paraspinal muscles and spinal canal that were associated with an intramuscular injection administered 1 week earlier for a backache. After escalation of the antibiotherapy and intensive supportive measures, the patient showed improvement and was discharged after 8 weeks of antibiotherapy.The incidence of invasive SDSE infections has been growing, especially in immunosupressed patients. In this case, despite no predisposing factor identified, it evolved to severe sepsis. The intramuscular injection, a trivialised but not harmless procedure, was the assumed port of entry, as previously described in another case report.
Facts and values: on the acceptability of risks in children’s sport using the example of rugby — a narrative review
Authors: Quarrie Kenneth Lincoln , Brooks John H M , Burger Nicholas , Hume Patria A , Jackson Steve 
Published: July 2017

A clash of values has been identified between those who assert that:1. all childhood injuries, regardless of origin, are inherently undesirable and should be prevented and;2. those who believe that some measure of injury to children is an acceptable compromise for the physical benefits associated with physical activity and the development of abilities to appraise and deal with risks.A debate regarding whether the tackles and collisions permitted in schools’ rugby represent acceptable risks, and what steps should be taken if they do not, exemplifies the issue.Questions regarding the magnitude of injury risks in sport are issues of fact and can be quantified via the results of injury surveillance studies. Risks are neither high nor low in isolation; they are relatively high or low with reference to other activities or across groups participating in an activity. Issues of the acceptability of a given degree of risk are value dependent. Research regarding perceptions of risk reveals wide variations in the degree of risk people view as acceptable. Factors impacting on risk perception include whether the risks are well known and understood, whether they are ‘dread’ risks and the degree to which people undertake the risks voluntarily and feel they have control over them.Based on the evidence currently available, the risks to children playing rugby do not appear to be inordinately high compared with those in a range of other childhood sports and activities, but better comparative information is urgently needed. Further evidence, however, should not necessarily be expected to result in the resolution of acceptable risk debates—pre-existing values shape our perspectives on whether new evidence is relevant, valid and reliable.
Translating staff experience into organisational improvement: the HEADS-UP stepped wedge, cluster controlled, non-randomised trial
Authors: Pannick Samuel , Athanasiou Thanos , Long Susannah J , Beveridge Iain , Sevdalis Nick 
Published: July 2017

ObjectivesFrontline insights into care delivery correlate with patients’ clinical outcomes. These outcomes might be improved through near-real time identification and mitigation of staff concerns. We evaluated the effects of a prospective frontline surveillance system on patient and team outcomes.DesignProspective, stepped wedge, non-randomised, cluster controlled trial; prespecified per protocol analysis for high-fidelity intervention delivery.ParticipantsSeven interdisciplinary medical ward teams from two hospitals in the UK.InterventionProspective clinical team surveillance (PCTS): structured daily interdisciplinary briefings to capture staff concerns, with organisational facilitation and feedback.Main measuresThe primary outcome was excess length of stay (eLOS): an admission more than 24 hours above the local average for comparable patients. Secondary outcomes included safety and teamwork climates, and incident reporting. Mixed-effects models adjusted for time effects, age, comorbidity, palliation status and ward admissions. Safety and teamwork climates were measured with the Safety Attitudes Questionnaire. High-fidelity PCTS delivery comprised high engagement and high briefing frequency.ResultsImplementation fidelity was variable, both in briefing frequency (median 80% working days/month, IQR 65%–90%) and engagement (median 70 issues/ward/month, IQR 34–113). 1714/6518 (26.3%) intervention admissions had eLOS versus 1279/4927 (26.0%) control admissions, an absolute risk increase of 0.3%. PCTS increased eLOS in the adjusted intention-to-treat model (OR 1.32, 95% CI 1.10 to 1.58, p=0.003). Conversely, high-fidelity PCTS reduced eLOS (OR 0.79, 95% CI 0.67 to 0.94, p=0.006). High-fidelity PCTS also increased total, high-yield and non-nurse incident reports (incidence rate ratios 1.28–1.79, all p<0.002). Sustained PCTS significantly improved safety and teamwork climates over time.ConclusionsThis study highlighted the potential benefits and pitfalls of ward-level interdisciplinary interventions. While these interventions can improve care delivery in complex, fluid environments, the manner of their implementation is paramount. Suboptimal implementation may have an unexpectedly negative impact on performance.Trial registration numberISRCTN 34806867 (http://www.isrctn.com/ISRCTN34806867).