bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘The Messenger of a Faithful Heart’
Authors: Giarusso Richard 
Published: September 2016

Abstract
Many question the integrity of Schwanengesang as a ‘cycle,’ and the place of ‘Die Taubenpost’ in the set still generates heated debate. Performers and critics often dismiss the song as a trifling successor to the weighty Heine settings, and one observer has suggested that ‘its place, if it has one, in performances of Schwanengesang is as an encore’. Much of Schubert’s biography in 1828 and our understanding of his ‘late’ style has been disproportionately colored by Winterreise and by the Heine songs in Schwanengesang. Yet, inasmuch as Schwanengesang lives up to its name, ‘Die Taubenpost’ is the only song in the set that truly represents the ‘last blossom’ of Schubert’s talent. Far from being a trivial coda to the brooding Heine songs, ‘Die Taubenpost’ embodies the quintessence of Schubert’s late style, answering the bleakness of ‘Der Doppelgänger’ with a cautious yet resilient optimism that is echoed in so many of the last works.
Interlude
Authors: Gilliver Peter 
Published: September 2016

Abstract
This chapter describes the methodology followed by the compilers of the first edition of the OED. It sets out the various components of the process of compilation: the collection of quotations; the pre-processing (‘sub-editing’) of these by volunteers working in advance of the in-house lexicographers; the drafting and revision of entries, first by the Editors’ assistants, then by the Editors themselves (including selection of quotations, organization of senses and sub-senses, pronunciation, variant spellings, and etymology); correspondence with specialist consultants; and the printing and correction of proofs and revises (including the substantial contribution made in these stages by external proofreaders), culminating in the passing for press of finished pages of the Dictionary. Some aspects of the variation in editorial approach between the four Editors are also explored.
And then there were four: 1897–1915
Authors: Gilliver Peter 
Published: September 2016

Abstract
This chapter describes the continuing expansion of the team of lexicographers compiling the OED during the years following 1897, in the course of which William Craigie and Charles Onions were appointed as the Dictionary’s third and fourth Editors—the latter notwithstanding his brief and unexplained departure from the staff in 1899. The appointment of Charles Cannan as Secretary to the Delegates seems to have marked the beginning of a period of smoother progress for the project, although the work of the lexicographers continued to be carefully scrutinized by OUP; various ideas for improving productivity, including bonus schemes, were proposed, and these are described. Also during this period, work began on two other OUP dictionaries which draw on the OED, the Shorter OED and the Concise Oxford Dictionary, and these are explored. The chapter ends with the death of James Murray, and an assessment of his contribution to the Dictionary.
Spiritual/Religious Beliefs & Medication Adherence in Black Women with Hypertension
Authors: Abel Willie M. , Greer Danice B. 
Published: September 2016

ABSTRACT:
Black women have the highest rate of hypertension (HTN) in the U.S. and perhaps the world. Because they are deemed the most religiously devout group in the U.S., it is plausible that faithfulness to spiritual/religious practices may yield more adherence to HTN medication regimens. This study examined spiritual/religious beliefs in relation to antihypertensive medication adherence in Black women with HTN. Although results showed no association between beliefs and adherence, women who developed trusting relationships with their healthcare provider were more likely to be adherent to their medications.
Toluidine Blue and Hematoxylin and Eosin Stains are Comparable in Evaluating Squamous Cell Carcinoma During Mohs
Authors: Styperek Andrew R. , Goldberg Leonard H. , Goldschmidt Laura E. , Kimyai-Asadi Arash 
Published: September 2016

BACKGROUND
Histologic examination of tissue is the foundation of Mohs micrographic surgery because determination of surgical margins influences whether additional tissue will be taken. Currently, there is no large focused study comparing toluidine blue (TB) and hematoxylin and eosin (H&E) stains in the evaluation of squamous cell carcinoma (SCC).

OBJECTIVE
This study evaluates whether TB and H&E are comparable in assessing the presence of tumor in frozen sections of SCC.

MATERIALS AND METHODS
One hundred eighty-six randomized slides representing 93 tissue pieces from 36 tumors were examined by 3 Mohs surgeons (1 Accreditation Council for Graduate Medical Education fellow and 2 fellowship-trained surgeons) and compared using a template that documented the presence and location of tumor on the slides.

RESULTS
The evaluation of SCC with H&E and TB stains was highly concordant, with concordant identification of SCC in 96%, 96%, and 94% of tissue layers among the 3 Mohs surgeons ARS, LHG, and AK-A, respectively.

CONCLUSION
Toluidine blue and H&E stains are statistically similar in their ability to detect SCC and guide Mohs surgical decision-making.
Population Pharmacokinetics of Everolimus in Relation to Clinical Outcomes in Patients With Advanced Renal Cell Carcinoma
Authors: Tanaka Atsuko , Yano Ikuko , Shinsako Keiko , Sato Eriko , Fukudo Masahide , Masuda Satohiro , Yamasaki Toshinari , Kamba Tomomi , Ogawa Osamu , Matsubara Kazuo 
Published: September 2016

Background:
Everolimus has been used for the treatment of unresectable or metastatic renal cell carcinoma (RCC). Here, we measured blood concentrations of everolimus to obtain the population pharmacokinetic parameters and to examine the relationship between blood concentration and clinical outcomes.

Methods:
Twenty-two Japanese patients were enrolled. Blood samples were collected before and 2, 4, 8, and 24 hours after drug administration on days 1 and 8 of everolimus therapy (5 or 10 mg) from inpatients; occasional samples were collected from outpatients. Blood concentrations of everolimus were measured by high-performance liquid chromatography with tandem mass spectrometry. Population pharmacokinetic analysis was conducted using the NONMEM software.

Results:
Everolimus pharmacokinetics was best described by a 2-compartment model with population mean estimates of apparent oral clearance of 10.0 L/h and an interindividual variability of 42.4%. There was no relationship between overall best responses and the predicted trough concentrations at day 8. The predicted trough concentration in patients who terminated everolimus treatment owing to adverse drug reactions (ADRs) was significantly higher than in patients who stopped the treatment owing to disease progression or other reasons (27.6 ± 3.1 versus 15.7 ± 2.3 ng/mL; mean ± SEM). Patients who terminated the treatment owing to ADRs had significantly shorter time-to-treatment failure than other patients (112 versus 187 days, median).

Conclusions:
This study reports the first population pharmacokinetic parameters of everolimus in patients with RCC. Individual dose adjustment based on everolimus blood concentrations helps to avoid early drug cessation due to ADRs.
Teaching Surgical Procedures with Movies: Tips for High-quality Video Clips
Authors: Jacquemart Mathieu , Bouletreau Pierre , Breton Pierre , Mojallal Ali , Sigaux Nicolas 
Published: September 2016

Summary:
Video must now be considered as a precious tool for learning surgery. However, the medium does present production challenges, and currently, quality movies are not always accessible. We developed a series of 7 surgical videos and made them available on a publicly accessible internet website. Our videos have been viewed by thousands of people worldwide. High-quality educational movies must respect strategic and technical points to be reliable.
The Plastic Surgery Compass: Navigating the Reconstructive Ladder in the Personalized Health Care Era
Authors: Sandberg Lars Johan M. 
Published: September 2016

Summary:
The reconstructive ladder and the reconstructive elevator have withstood the test of time as didactic tools for resident education. Over time, many alternative models have been suggested to incorporate the technological advances in plastic surgery, but none of them have focused on the patient. Changes in practice and the trend toward personalized health care demand a 360-degree evaluation and solution of surgical problems incorporating patient-specific characteristics. We, therefore, suggest the concept of the plastic surgery compass to navigate the ladder.
Haematopoietic stem cell transplantation in inborn errors of metabolism
Authors: Chiesa Robert , Wynn Robert F. , Veys Paul 
Published: September 2016

Purpose of review
This review summarizes the main results of haematopoietic stem cell transplantation (HSCT) in selected inborn errors of metabolism (IEMs).

Recent findings
Early diagnosis and immediate referral to an IEM specialist is of paramount importance to improve clinical outcome: patients who are transplanted early or in their presymptomatic phase generally achieve better correction of their somatic symptoms and neurocognitive development. Long-term outcome in children with Hurler syndrome is influenced by age at HSCT, baseline clinical status and post-HSCT enzyme levels. Myeloablative Busulfan-based conditioning regimens with therapeutic drug monitoring are recommended to achieve full donor engraftment and more robust enzyme delivery after HSCT. Gene therapy can lead to production of supranormal enzyme levels, and preliminary clinical results are also promising in IEMs historically not responsive to allogeneic HSCT.

Summary
Allogeneic HSCT has largely contributed to the improved survival and quality of life of many children affected by IEMs. Neonatal screening could enable earlier HSCT, and this might significantly reduce residual disease burden and improve clinical outcome. Novel strategies, such as gene therapy, have shown encouraging clinical results in selected IEMs and might become more widely available in the future, with potentially better enzyme delivery and reduced transplant-related toxicity.
Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression
Authors: Zeng Yanni , Navarro Pau , Xia Charley , Amador Carmen , Fernandez-Pujals Ana M. , Thomson Pippa A. , Campbell Archie , Nagy Reka , Clarke Toni-Kim , Hafferty Jonathan D. , Smith Blair H. , Hocking Lynne J. , Padmanabhan Sandosh , Hayward Caroline , MacIntyre Donald J. , Porteous David J , Haley Chris S. , McIntosh Andrew M. 
Published: September 2016

AbstractBackgroundBoth genetic and environmental contributions to risk of depression have been identified, but estimates of their effects are limited. Commonalities between major depressive disorder (MDD) and self-declared depression (SDD) are also unclear. Dissecting the genetic and environmental contributions to these traits and their correlation would inform the design and interpretation of genetic studies.MethodsUsing data from a large Scottish family-based cohort (GS:SFHS, N=21,387), we estimated the genetic and environmental contributions to MDD and SDD. Genetic effects associated with common genome-wide genetic variants (SNP heritability) and additional pedigree-associated genetic variation and Non-genetic effects associated with common environments were estimated using linear mixed modeling (LMM).FindingsBoth MDD and SDD had significant contributions from effects of common genetic variants, the additional genetic effect of the pedigree and the common environmental effect shared by couples. The correlation between SDD and MDD was high (r=1⋅00, se=0⋅21) for common-variant-associated genetic effects and moderate for both the additional genetic effect of the pedigree (r=0⋅58, se=0⋅08) and the couple-shared environmental effect (r=0⋅53, se=0⋅22).InterpretationBoth genetics and couple-shared environmental effects were the major factors influencing liability to depression. SDD may provide a scalable alternative to MDD in studies seeking to identify common risk variants. Rarer variants and environmental effects may however differ substantially according to different definitions of depression.FundingStudy supported by Wellcome Trust Strategic Award 104036/Z/14/Z. GS:SFHS funded by the Scottish Government Health Department, Chief Scientist Office, number CZD/16/6.
Temporal regulation of epithelium formation
Authors: Von Stetina Stephen E. , Liang Jennifer , Marnellos Georgios , Mango Susan E. 
Published: September 2016

Abstract/SummaryTo establish the animal body plan, embryos link the external epidermis to the internal digestive tract. InCaenorhabditis elegans,this linkage is achieved by the Arcade Cells, which form an epithelial bridge between the foregut and epidermis, but little is known about how development of these three epithelia is coordinated temporally. The Arcade Cell epithelium is generated after the epidermis and digestive tract epithelia have matured, ensuring that both organs can withstand the mechanical stress of embryo elongation; mis-timing of epithelium formation leads to defects in morphogenesis. Here, we report that temporal regulation of the Arcade Cell epithelium is mediated by the pioneer transcription factor PHA-4/FoxA, the cytoskeletal regulator ZEN-4/MKLP and the polarity protein PAR-6. We find that PHA-4 activates expression of a broad cohort of epithelial genes. However, accumulation of protein is delayed by ZEN-4, acting in concert with its partner CYK-4/MgcRacGAP. Finally, PAR-6 localizes factors within adherens junctions and at the apical surface, leading to Arcade Cell polarity. The results reveal that the timing of a landmark event during embryonic morphogenesis is mediated by the concerted action of four proteins that delay the formation of an epithelial bridge. In addition, we find that FoxA associates with many epithelial genes in mammals, suggesting that regulation of epithelial identity may be a conserved feature of FoxA factors and a contributor to FoxA function in development and cancer.
Seasonal influenza circulation patterns and projections for 2016-2017
Authors: Bedford Trevor , Neher Richard A. 
Published: September 2016

AbstractThis is not meant as a comprehensive report, but is instead intended as particular observations that may be of relevance. Please also note that observed patterns reflect the GISAID database and may not be entirely representative of underlying dynamics. All analyses are based on the nextflu pipeline [1] with continual updates posted to Correspondence:http://nextflu.org.
Performance Evaluation of Empirical Mode Decomposition Algorithms for Mental Task Classification
Authors: Gupta Akshansh , Kumar Dhirendra , Chakraborti Anirban , Sharma Kiran 
Published: September 2016

AbstractBrain Computer Interface (BCI), a direct pathway between the human brain and computer, is one of the most pragmatic applications of EEG signal. The electroencephalograph (EEG) signal is one of the monitoring techniques to observe brain functionality. Mental Task Classification (MTC) based on EEG signals is a demanding BCI. Success of BCI system depends on the efficient analysis of these signals. Empirical Mode Decomposition (EMD) is a filter based heuristic technique which is utilized to analyze EEG signal in recent past. There are several variants of EMD algorithms which have their own merits and demerits. In this paper, we have explored three variants of EMD algorithms named Empirical Mode Decomposition (EMD), Ensemble Empirical Mode Decomposition (EEMD) and Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) on EEG data for MTC-based BCI. Features are extracted from EEG signal in two phases; in the first phase, the signal is decomposed into different oscillatory functions with the help of different EMD algorithms and eight different parameters (features) are calculated for each function for compact representation in the second phase. These features are fed into Support Vector Machine (SVM) classifier to classify the different mental tasks. We have formulated two different types of MTC, the first one is binary and second one is multi-MTC. The proposed work outperforms the existing work for both binary and multi mental tasks classification.
Biochemical, spectroscopic and X-ray structural analysis of deuterated multicopper oxidase CueO prepared from a new expression construct for neutron crystallography
Authors: Akter Mahfuza , Inoue Chika , Komori Hirofumi , Matsuda Nana , Sakurai Takeshi , Kataoka Kunishige , Higuchi Yoshiki , Shibata Naoki 
Published: September 2016

Multicopper oxidases oxidize various phenolic and nonphenolic compounds by using molecular oxygen as an electron acceptor to produce water. A multicopper oxidase protein, CueO, fromEscherichia coliis involved in copper homeostasis in the bacterial cell. Although X-ray crystallographic studies have been conducted, the reduction mechanism of oxygen and the proton-transfer pathway remain unclear owing to the difficulty in identifying H atoms from X-ray diffraction data alone. To elucidate the reaction mechanism using neutron crystallography, a preparation system for obtaining large, high-quality single crystals of deuterated CueO was developed. Tiny crystals were obtained from the deuterated CueO initially prepared from the original construct. The X-ray crystal structure of the deuterated CueO showed that the protein contained an incompletely truncated signal sequence at the N-terminus, which resulted in the heterogeneity of the protein sample for crystallization. Here, a new CueO expression system that had an HRV3C cleavage site just after the signal sequence was constructed. Deuterated CueO from the new construct was expressed in cells cultured in deuterated algae-extract medium and the signal sequence was completely eliminated by HRV3C protease. The deuteration level of the purified protein was estimated by MALDI-TOF mass spectrometry to be at least 83.2% compared with nondeuterated protein. Nondeuterated CueO crystallized in space groupP21, with unit-cell parametersa= 49.51,b= 88.79,c = 53.95 Å, β = 94.24°, and deuterated CueO crystallized in space groupP212121, with unit-cell parametersa= 49.91,b= 106.92,c= 262.89 Å. The crystallographic parameters for the crystals of the new construct were different from those previously reported for nondeuterated crystals. The nondeuterated and deuterated CueO from the new construct had similar UV–Vis spectra, enzymatic activities and overall structure and geometry of the ligands of the Cu atoms in the active site to those of previously reported CueO structures. These results indicate that the CueO protein prepared using the new construct is suitable for further neutron diffraction studies.
Neurolinguistic programming: does it have a role in supporting learning or OD interventions?
Authors: Wake Lisa 
Published: September 2016

PurposeThis article provides an overview and consultant experience of using NLP in learning and organizational development situations.Design/methodology/approachThe paper includes a theoretical discussion of NLP as a potential learning and OD tool and practical examples of how it has been utilized within the context of HR and LD practices.FindingsThe paper demonstrates that NLP can be effectively used in a learning and OD context and has both benefits and limitations.Practical implicationsNLP is a “soft skills” toolkit that develops and builds on performance excellence and as such is ideally placed to be used as an adjunct or support to standard learning and OD practices. It also provides an excellent diagnostic and change management tool to enable effective OD.Social implicationsThe human potential is a core asset of many businesses. NLP works with the subjective experience of individuals and provides an opportunity to harness the strengths within the workforce and use these to maximum benefit.Originality/valueThe paper proposes that NLP is an effective support methodology to standard learning and OD practices and provides simple examples of how this has been done.
Glove-based virtual hand grasping for virtual mechanical assembly
Authors: Li JingRong , Xu YuHua , Ni JianLong , Wang QingHui 
Published: September 2016

Purpose
Hand gesture-based interaction can provide far more intuitive, natural and immersive feelings for users to manipulate 3D objects for virtual assembly (VA). A mechanical assembly consists of mostly general-purpose machine elements or mechanical parts that can be defined into four types based on their geometric features and functionalities. For different types of machine elements, engineers formulate corresponding grasping gestures based on their domain knowledge or customs for ease of assembly. Therefore, this paper aims to support a virtual hand to assemble mechanical parts.

Design/methodology/approach
It proposes a novel glove-based virtual hand grasping approach for virtual mechanical assembly. The kinematic model of virtual hand is set up first by analyzing the hand structure and possible movements, and then four types of grasping gestures are defined with joint angles of fingers for connectors and three types of parts, respectively. The recognition of virtual hand grasping is developed based on collision detection and gesture matching. Moreover, stable grasping conditions are discussed.

Findings
A prototype system is designed and developed to implement the proposed approach. The case study on VA of a two-stage gear reducer demonstrates the functionality of the system. From the users’ feedback, it is found that more natural and stable hand grasping interaction for VA of mechanical parts can be achieved.

Originality/value
It proposes a novel glove-based virtual hand grasping approach for virtual mechanical assembly.
Force and position deviations estimation for ultra-thin tube assembly
Authors: Shao Chao , Ye Xin , Zhang Zhijing , Zhou Dengyu , Liu Yuhong 
Published: September 2016

Purpose
Micro ultra-thin tubes have important implications in aerospace, nuclear energy and other fields. In microassembly process, these parts are characterized by following reasons: the small size can easily lead to damage when gripping, even for low intensity and the parts are mainly affected by the instability of light source, for vision-based systems, the visual information about ultra-thin tubes is difficult to gather and the contact state is hard to monitor.

Design/methodology/approach
The paper presents a new method to adjust the position deviations based on contact forces during microassembly processes. Specific research is such that the assembly model was established based both on mechanic calculation and numerical simulation; the assembly task was carried out on an in-house microassembly system with coaxial alignment function (MSCA), the contact statements were controlled based on force sensor feedback signals and the model of the relationship between contact force and assembly deviations was established. Through a comparative study, the results of experiment and simulation differ by less than 11 per cent, validating the accuracy and feasibility of the method.

Findings
The model of assembly force and position deviations of micro ultra-thin tubes based on MSCA has been built. Besides, the assembly force threshold, and the assembly process parameters have been obtained.

Originality/value
The assembly process parameters obtained from experiments can be applied in the precision assembly and provide theoretical guidance and technical support to the precision assembly of the multi-scale parts.