bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cimetidine Reduces Interleukin‐6, Matrix Metalloproteinases‐1 and ‐9 Immunoexpression in the Gingival Mucosa of Rat Molars With Induced Periodontal Disease
Authors: de Oliveira Priscila Aparecida , de Pizzol‐Júnior José Paulo , Longhini Renata , Sasso‐Cerri Estela , Cerri Paulo Sérgio 
Published: September 2016

Background: Histamine seems to act, via H2 receptor, on inflammatory processes by stimulating interleukin (IL)‐6 and matrix metalloproteinase (MMP) release. As cimetidine is an H2 receptor antagonist, the authors hypothesize that this antiulcer drug reduces IL‐6, MMP‐1, and MMP‐9 immunoexpression in gingiva with induced periodontal disease (PD). To confirm a possible modulatory role of IL‐6 on MMPs, the relationship between IL‐6/MMP‐1 and IL‐6/MMP‐9 immunoexpression was evaluated.Methods: Forty‐six male rats were distributed into the cimetidine group (CimG: received daily intraperitoneal injections of 100 mg/kg of body weight of cimetidine) or the saline group (SG). PD was induced by cotton ligature around the maxillary left first molars (PDSG and PDCimG). The right molars were used as controls (SG and CimG). After 7, 15, 30, and 50 days, maxillary fragments were processed for paraffin embedding or for transmission electron microscopy. Tartrate‐resistant acid phosphatase (TRAP)‐positive osteoclasts in the alveolar process surface and number of IL‐6, MMP‐1, and MMP‐9‐immunolabeled cells in the gingival mucosa were quantified. Statistical analyses were performed (P ≤0.05).Results: In PDSG and PDCimG, gingival mucosa exhibited few collagen fibers among numerous inflammatory cells. In PDCimG, the number of TRAP‐positive osteoclasts and IL‐6, MMP‐1, and MMP‐9‐immunolabeled cells was significantly lower than in PDSG at all periods. A positive correlation between IL‐6/MMP‐1 and IL‐6/MMP‐9 was detected in PDSG and PDCimG.Conclusion: Cimetidine decreases bone loss through reduction of osteoclast number and induces reduction of IL‐6, MMP‐1, and MMP‐9 immunoexpression, reinforcing the idea that the beneficial effect of cimetidine in PD may be due to reduction of IL‐6 immunolabeling in the inflamed gingival mucosa.
Optimized Platelet‐Rich Fibrin With the Low‐Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response
Authors: Fujioka‐Kobayashi Masako , Miron Richard J. , Hernandez Maria , Kandalam Umadevi , Zhang Yufeng , Choukroun Joseph 
Published: September 2016

Background: Over the past decade, use of leukocyte platelet‐rich fibrin (L‐PRF) has gained tremendous momentum in regenerative dentistry as a low‐cost fibrin matrix used for tissue regeneration. This study characterizes how centrifugation speed (G‐force) along with centrifugation time influence growth factor release from fibrin clots, as well as the cellular activity of gingival fibroblasts exposed to each PRF matrix.Methods: Standard L‐PRF served as a control (2,700 revolutions per minute [rpm]‐12 minutes). Two test groups using low‐speed (1,300 rpm‐14 minutes, termed advanced PRF [A‐PRF]) and low‐speed + time (1,300 rpm‐8 minutes; A‐PRF+) were investigated. Each PRF matrix was tested for growth factor release up to 10 days (eight donor samples) as well as biocompatibility and cellular activity.Results: The low‐speed concept (A‐PRF, A‐PRF+) demonstrated a significant increase in growth factor release of platelet‐derived growth factor (PDGF), transforming growth factor (TGF)‐β1, epidermal growth factor, and insulin‐like growth factor, with A‐PRF+ being highest of all groups. Although all PRF formulations were extremely biocompatible due to their autogenous sources, both A‐PRF and A‐PRF+ demonstrated significantly higher levels of human fibroblast migration and proliferation compared with L‐PRF. Furthermore, gingival fibroblasts cultured with A‐PRF+ demonstrated significantly higher messenger RNA (mRNA) levels of PDGF, TGF‐β, and collagen1 at either 3 or 7 days.Conclusions: The findings from the present study demonstrate modifications to centrifugation speed and time with the low‐speed concept favor an increase in growth factor release from PRF clots. This, in turn, may directly influence tissue regeneration by increasing fibroblast migration, proliferation, and collagen mRNA levels. Future animal and clinical studies are now necessary.
Board Competencies, Network Ties And Risk Management Disclosure Practices In Non-Profit Organizations
Authors: Arshad Roshayani , Bakar Noorbijan Abu , Othman Faizah 
Published: September 2016

In the current challenging economic environment, non-profit organizations (NPOs) are exposed to an array of risks and some of these risks are unique due to the characteristics of the organizations. Understanding and managing these risks are crucial in ensuring sustainability of the NPOs and the responsibility lies with the board. However, risks management and disclosure of risks in NPOs is less well developed relative to for profit organizations and this may affect boards’ role in enhancing risk management practices of these organizations. As such, this study aims to examine the relationships between certain board characteristics: board competencies, network ties and risk management disclosure practices in NPOs. Information on these variables are obtained from content analysis of annual reports and Financial Information Forms of 219 NPOs registered with Companies Commission of Malaysia for the financial period 2011. Results of this study reveal that the overall extent of risk management disclosure practices is at a moderate level. In addition, only board competencies are significantly positively related to the extent of risk management disclosure practices while network ties are not. This infers that some board members acknowledge the importance of being engaged in risk management decision. However, lack of specific guide on risk management in NPOs may reduce the motivation of some board members to do so. The guidelines and relevant trainings to board members provided by relevant authorities may increase the understanding of key risks and management of these risks as part of good governance in NPOs.
Propuesta metodológica para el análisis de las relaciones entre discurso e identidad
Authors: Fonseca Mendoza Clara Inés 
Published: September 2016

Este artículo presenta un marco metodológico centrado en el análisis de las relaciones entre discurso e identidad, basado en la Teoría de la Valoración y en la consideración de los significados globales (tópicos) y locales, y el modo como ellos conducen a las estrategias de auto-presentación positiva y presentación negativa de los otros. La relación entre discurso e identidad se asocia con un estudio sobre formas de racismo cotidiano percibidas en Cartagena, Colombia. Debe recalcarseque se trata de presentar una propuesta metodológica; por esta razón, no se realiza un análisis del discurso en estricto sentido.Palabras clave: discurso, identidad, discriminación percibida. AbstractThis article presents a methodological framework for analysis of the relations between discourse and identity, based on the Appraisal Theory and on the consideration of global and local meanings and the way these lead to strategies of positive self-presentation and negative presentation of others. The relation between discourse and identity is associated to a study on forms of everyday racism perceived in Cartagena. This is a methodological proposal; for that reason, there is no discourse analysis in stricto sensu.Key words: Discourse, identity, perceived discrimination
Muñoz Fernández, R. (2012). Temas y problemas en la novela colombiana 1998-2008. Bogotá D.C.: Universidad Distrital Francisco José de Caldas/Colección Diálogos.
Authors: Parra Triana Clara María 
Published: September 2016

No es en vano que inicie esta reseña con un epígrafe de Alfonso Reyes, pues desde su conceptualización, el ejercicio de la crítica ha perdido de forma definitiva el carácter de ejercicio amable. Ejercer la crítica es –ha de ser, más bien- como invitar a alguien “a pasear en la nopalera”; el paseo promete nuevas aventuras,aunque estas nos puedan rasgar la piel y formar heridas.
Una mirada a "Historias de mujeres infames"
Authors: Velásquez Muñoz Heidy Jazmín 
Published: September 2016

El presente ar tículo es la introducción al proceso de investigación/creación de “Historias de Mujeres Infames” (Trabajo de g rado de la Maestría en Literatura, UPTC), en donde se quiere explorar el tema de la infamia, a través de la escritura de biog rafías imaginarias de campesinas de la primera mitad del s. XX en San Gil y El Socorro, Santander. Se quiere aprovechar el fenómeno literario para cuestionar la manera en que la historia ha sido contada desde una óptica del poder masculino. Por lo tanto, este artículo busca develar la importancia de la voz de la infame en la literatura y en la formación de la memoria de los pueblos dando una ojeada a algunos de los autores que han explorado a profundidad este tema en distintas épocas. Palabras clave: Literatura, infame, mujer, historia, machismo, biografías imaginarias, poder. AbstractThis article is an introduction to the creative research process « (His)tories of Infamous Women» (thesis project presented at the Masters in Literature, UPTC), which explores the topic of infamy, through the writing of imaginary biographies of peasant women from the beginning of the XXc in San Gil and Socorro, Santander. This project uses the literary phenomenon to question the way in which history has been told from a male view point. For this reason, this article reveals the importance of the voice of the infamous subjects in literature and examines the construction of memory in a culture, in the company of authors who have explored this topic in different moments. Key Words: Literature, infamous, history, machismo, imaginary biographies, power.
AVALIAÇÃO DE DESEMPENHO DA SUSTENTABILIDADE FINANCEIRA DA UNIVERSIDADE DO MINDELO (CABO VERDE): UM MODELO MULTICRITÉRIO CONSTRUTIVISTA
Authors: Cardoso Thuine Lopes , Ensslin Sandra Rolim , Dias Juscelino 
Published: September 2016

Este artigo, de natureza exploratória-descritiva, tem por objetivo construir um modelo multicritério de avaliação de desempenho construtivista para apoiar a gestão da sustentabilidade financeira da Universidade do Mindelo (UM), sediada em Cabo Verde, na África. Para tal, selecionou-se a metodologia Multicritério de Apoio à Decisão-Construtivista (MCDA-C). Nas entrevistas com o pró-reitor, identificaram-se 51 conceitos agrupados nas áreas de preocupação: Planos e Orçamentos; Negociações com Entidade Financiadoras; Execução Financeira e Controladoria. O modelo construído permitiu: (i) a avaliação global do desempenho da UM, a qual indicou 50 pontos, em uma escala de 0 a 100; (ii) a proposta de ações de melhoria, para os indicadores que se encontravam com um desempenho no nível comprometedor, que, se implementadas, alavancariam o desempenho da UM; e, (iii) o cotejamento dos indicadores com os propostos pela literatura onde percebeu-se que a maioria não foi incorporada pelo modelo ah doc desenvolvido ao viés construtivista da pesquisa.
O PAPA DA CONVERSÃO E DA MISERICÓRDIA
Authors: Konings SJ Johan , De Mori SJ Geraldo Luiz 
Published: September 2016

Os artigos temáticos desta publicação apresentam o pontificado do Papa Francisco, nascido Jorge Mario Bergoglio, em Buenos Aires, 1936, 266º Papa da Igreja Católica e atual Chefe de Estado do Vaticano, eleito papa em 13 de março de 2013, depois da renúncia do Papa Bento XVI (o primeiro papa a renunciar depois de Gregório XII em 1415), com o lema “Miserando atque eligendo”.
A Case Study of Open and Cased Hole Well Completions in More than 400 Wells in On-Shore Block in India
Authors: Panigrahi Nishant , Bohra Avinash , Ranjan Ashish , Nekkanti Satish , Kumar Abhishek , Kestwal Ashish , Vaibhav Ankit , Jain Himanshu , Kumar Animesh 
Published: September 2016

Abstract
This paper summarizes the completion designs and operational challenges of successful well completions in more than 400 wells in the Rajasthan onshore block of Northwest India. The Rajasthan onshore block has three core fields, with a total 37 oil and gas discoveries. These wells were completed in over three and a half years without compromising aspects of health, safety, or the environment. During the campaign, a commendable feat of zero HSE incidents was observed.
These wells are broadly categorized as development and exploration wells and include a variety of both open- and cased-hole well completions. The completion systems are wide-ranging, varying from monobore conventional completions to open-hole, sand-control applications. The scope of work and challenging parameters include highly deviated open-hole and cased-hole sections, along with complex workovers. A wide range of products and services were designed to maximize well production. The completion design included a variety of packers, flow-control devices, intervention solutions, and other relevant completion tools.
There were various operational, health, safety, environmental, logistical, and manufacturing-related challenges that were overcome to drill and complete the wells. The purpose of this paper is to provide insight into the well types, completion designs, and to discuss the associated challenges.
The technology and practices established from these successful operations have become the standard operating procedures for completion jobs. This paper will take the reader through the evolution of well-completions technology, from the early days, when perceived risk was both hindered and was the spark for innovation, to the present time, when this technology is routinely used to meet production and reservoir development goals.
Bisphenol A Release: Survey of the Composition of Dental Composite Resins
Authors: Dursun Elisabeth , Fron-Chabouis Hélène , Attal Jean-Pierre , Raskin Anne 
Published: September 2016

Background:
Bisphenol A (BPA) is an endocrine disruptor with potential toxicity. Composite resins may not contain pure BPA, but its derivatives are widely used. Several studies found doses of BPA or its derivatives in saliva or urine of patients after composite resin placement.

Objective:
The aims of this study were to establish an exhaustive list of composite resins marketed in Europe and their composition, and to assess the extent of BPA derivatives used.

Methods:
A research on manufacturers' websites was performed to reference all composite resins marketed in Europe, then their composition was determined from both material safety data sheets and a standardized questionnaire sent to manufacturers. Manufacturers had to indicate whether their product contained the monomers listed, add other monomers if necessary, or indicate “not disclosed”.

Results:
160 composite resins were identified from 31 manufacturers and 23 manufacturers (74.2%) responded to the survey. From the survey and websites, the composition of 130 composite resins (81.2%) was: 112 (86.2%) based on BPA derivatives, 97 (74.7%) on bis-GMA, 17 (13.1%) without monomer derived from BPA (UDMA, sometimes with TEGDMA) and 6 (4.6%) with UDMA (only);
1 (0.8%) did not contain a BPA derivative or UDMA or TEGDMA. Pure BPA was never reported.

Conclusion:
This work has established a list of 18 composite resins that contain no BPA derivative. Manufacturers should be required to report the exact composition of their products as it often remains unclear or incomplete.
Characteristics of Sympathetic Ophthalmia in a Single International Center
Authors: Guzman-Salas Pablo Jose , Serna-Ojeda Juan Carlos , Guinto-Arcos Ethel Beatriz , Pedroza-Seres Miguel 
Published: September 2016

Aim:
To report the main features of sympathetic ophthalmia in a referral ophthalmology center.

Methods:
Retrospective clinical study. We reviewed clinical records of patients with diagnosis of sympathetic ophthalmia attending the Uveitis Department from 2007 to 2013. Patients were selected by clinical criteria. Descriptive statistics were used to assess variables.

Results:
Twenty patients were included for analysis, 13 males and 7 females. Mean follow up was 1 year. The median age of presentation was 50 years. Fifty percent had history of ocular trauma and 50% had history of intraocular surgery, of which 40% underwent phacoemulsification. The time between injury and onset of symptoms ranged from 1 to 456 months. Most common ocular manifestations were mutton fat keratic precipitates and anterior chamber inflammation. All patients received oral prednisone as single or combined therapy. Sixty percent of the sympathizing eyes improved two or more lines of vision and 20% lost two or more lines of vision.

Conclusion:
This report from a single center adds to the body of literature of sympathetic ophthalmia occurring in a specific population. Our data found a high proportion of patients with sympathetic ophthalmia after phacoemulsification.
Copal de Bursera bipinnata. Una resina mesoamericana de uso ritual
Authors: Montúfar López Aurora 
Published: September 2016

El presente artículo muestra que el copal chino (Bursera bipinnata) era una resina ofrendada a los dioses en los rituales agrícolas mesoamericanos. Expone el proceso de su extracción en la cuenca del Río Balsas, el cual no ha cambiado en los últimos cinco siglos. Destaca el uso del copal en las festividades calendáricas de culto al Sol y dioses de la Tierra, Agua, Fuego, Viento y de la Guerra, pues su humo aromático, además de considerarse alimento divino, permitía el vínculo entre las deidades y humanos; y en los ritos de producción agrícola, la salud y el éxito en diversas labores de subsistencia. Finalmente se explica el uso actual en las festividades de Temalacatzingo (ritual vigente) como alegoría de la continuidad cultural mesoamericana, demostrando que el copal tiene un papel principal en los rituales de ofrenda a las entidades antiguas y cristianas.
Эффективность лечения пострадавших от холодовой травмы
Authors: Andreiev O.V. , Samoilenko H.Ye. , Syniachenko O.V. , Iehudina Ye.D. 
Published: September 2016

Цель и задачи исследования: оценить эффективность традиционных методов хирургического и консервативного лечения холодовой травмы, установить клинические, инструментальные и лабораторные факторы, ее определяющие, выделить прогностические критерии. Материал и методы. Под наблюдением находились 147 больных с отморожениями (128 мужчин и 19 женщин в возрасте от 16 до 79 лет). В 48 % случаев выполнены различные хирургические вмешательства, в 52 % лечение проводилось консервативно. Результаты. Ампутации конечностей проведены 18 % от числа больных с холодовой травмой, ампутации пальцев — 24 %, а полное сохранение анатомической функции рук и ног констатировано у 59 % пострадавших, причем эффективность лечения женщин с отморожениями оказалась лучше, чем мужчин, при этом с повышением возраста больных результаты лечебных мероприятий ухудшаются, негативно зависят от параметров тяжести отморожений, наличия сопутствующей сердечно-сосудистой и дыхательной патологии, степени нарушений кровотока в сосудах, интегральных изменений исходных лабораторных показателей (уровней белков, небелковых азотистых продуктов, параметров коагуляции крови, активности в ней креатинкиназы, физико-химических значений межфазной активности и вязкоэластичности сыворотки), которые могут обладать прогностической значимостью в отношении дальнейших оперативных вмешательств. Выводы. Результаты лечебных мероприятий при холодовой травме тесно связаны с клинико-лабораторным течением патологического процесса, а выделенные прогностические критерии позволят повысить качество медицинской технологии оказания помощи таким больным.
Можливості використання комплексних рослинних препаратів у лікуванні функціональних порушень біліарного тракту у хворих на цукровий діабет II типу
Authors: Sirchak Ye.S. 
Published: September 2016

Наведено результати комплексного обстеження та лікування 60 хворих на цукровий діабет ІІ типу з дискінезією жовчновивідних шляхів. Доведена клінічна ефективність препарату рослинного похо­дження Рафахолін Ц у комплексному лікуванні даного контингенту пацієнтів.
Синдром портальної гіпертензії: можливості сучасної діагностики
Authors: Меlanich S.L. , Chalyi M.V. 
Published: September 2016

У статті розглянуті можливості сучасної медицини в діагностиці синдрому портальної гіпертензії. Подані діагностичні критерії ультразвукових, ендоскопічних, рентгенологічних, ангіографічних і лабораторних методів в оцінці цього синдрому. Поєднане застосування декількох методів дослідження дозволяє диференціювати форму портальної гіпертензії, оцінити ступінь тяжкості та ризики розвитку її ускладнень.
CNS depressant activity of Chamomile flower methanol extract in mice
Authors: Taher Yousef A , Samud Awatef M. , Mezogi Jamal S. , Hamza Amel M. 
Published: September 2016

Matricaria chamomilla L. (Asteraceae) is a well-known plant in most ancient traditional medicine and highly used for the cure of numerous medical disorders, insomnia included. Using a sleep disturbed model, pentobarbital sodium and ether induce loss of righting reflex were applied for the evaluation of hypnotic and narcosis effects respectively. In the present study, the methanol extract of Matricaria chamomilla flower, at the i.p dose 300 mg/kg, showed considerable restful effect and significantly potentiate the hypnotic effect of pentobarbital sodium, both the latency to sleep and duration time, with a decrease value of 31.9% (P<0.001) and increase values of 53.3% (P<0.01) respectively. On the contrary, the Matricaria chamomilla flower methanol extract did not prolong the narcosis effect induced by ether. These findings indicate that Matricaria chamomilla methanol extract, at the dose used has a potential sedative-hypnotic effect as well as providing a scientific evidence for its traditional use as a sleep inducer.
Audit Firm Perspective on Audit Firm Rotation and Enhancing Independence: Evidence from PCAOB Comment Letters
Authors: Williams L. Tyler , Wilder W. Mark 
Published: September 2016

SUMMARY
This study examines practitioners' perspectives on audit firm rotation and alternative solutions to enhance independence in the audit industry as solicited by the PCAOB's “Concept Release on Audit Firm Rotation and Auditor Independence.” Accordingly, we synthesize the opinions found in comment letters of 15 American public accounting firms—eight of which are annually inspected by the PCAOB and seven of which are inspected tri-annually. Altogether, we find the firms generally offer homogenous rationale for opposition to audit firm rotation. However, most importantly, we note that the overwhelming majority of the alternative solutions offered by the firms to enhance the independence relationship between auditor and client lies with fortifying the audit committee. To that end, while regulators have generally attempted to strengthen independence by introducing regulation at the auditor level, our review indicates that perhaps a shift in regulatory philosophy is warranted—one that suggests progressing regulation at the client level.
Data Availability: Publicly available.