bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liposome-encapsulated dextrazide modifies spleen extracellular matrix composition in mice with chronic BCG-induced inflammation
Authors: Kim L. B. , Putyatina A. N. , Russkikh G. S. , Troitskij A. V. 
Published: September 2024

Fibrosis of parenchymal organs is a common complication of tuberculosis. In a model of BCG-induced inflammation in mice, changes in the metabolism of the extracellular matrix (ECM) of the spleen were demonstrated with the introduction of a liposome-encapsulated dextrazide (LEDZ) containing isoniazid and oxidized dextran.The mice were divided into 4 groups: 1 – intact animals; 2 – infected mice after a single intravenous injection of BCG vaccine. 6 mo after infection, a solution of LEDZ was administered intraperitoneally to mice of group 3 for 3 mo, and inhaled to mice of group 4. Group 2 mice showed the signs of pronounced spleen fibrosis (increased content of hyaluronan, hydroxyproline fractions) with activation of hyaluronidases, matrix metalloproteinases (MMP), α2-macroglobulin and an increased content of tissue inhibitors of MMP (TIMP-1 and TIMP-2) with respect to group 1 data. In group 3, changesin the structure of proteoglycans were noted (an increase in the content of uronic acids and galactose), a decrease in the content of hyaluronan and free hydroxyproline, an increase in the activity of hyaluronidases. The MMP activity and the TIMP content corresponded to the data of group 2. In group 4, the content of uronic acids and galactose in proteoglycans also increased, but peptide-bound hydroxyproline decreased and the hyaluronan content more noticeably decreased. The activity of all enzymes regulating the ECM metabolism reduced with respect to the data of group 2.Thus, intraperitoneal administration of LEDZ to infected mice led to activating hyaluronidases, changing the structure of proteoglycans, and decreasing the free hydroxyproline content. Inhalation administration of LEDZ, along with changes in the structure of proteoglycans, reduced the activity of MMP, hyaluronidases, α2-macroglobulin, the content of TIMP-1 and TIMP-2, peptide-bound hydroxyproline. The antifibrotic effect of LEDZ with inhalation administration was manifested in a decrease in peptide-bound hydroxyproline and in a more significant decrease in hyaluronan compared with intraperitoneal administration.Thus, intraperitoneal administration of LEDZ to infected mice led to activating hyaluronidases, changing the structure of proteoglycans, and decreasing the free hydroxyproline content. Inhalation administration of LEDZ, along with changes in the structure of proteoglycans, reduced the activity of MMP, hyaluronidases, α2-macroglobulin, the content of TIMP-1 and TIMP-2, peptide-bound hydroxyproline. The antifibrotic effect of LEDZ with inhalation administration was manifested in a decrease in peptide-bound hydroxyproline and in a more significant decrease in hyaluronan compared with intraperitoneal administration.
Changes in biochemical blood indicators in primary liver cancer associated with viruses
Authors: Kuzniatsou A. E. , Tsyrkunov V. M. , Ershova M. V. , Parai I. L. 
Published: September 2024

Currently, about million new cases of liver cancer (LC) are being registered annually in the world, causing death in 85 % of patients.The purpose of the study is to establish the features of changes in biochemical blood parameters in RP against the background of persistence of DNA/RNA viruses.Patients (n = 247) with morphologically established liver cancer, hepatitis and healthy individuals were examined. The subject of research was the biochemical and molecular biological parameters of DNA/RNA viruses. It was established that the nature of biochemical changes and disorders in patients with liver cancer indicates a simultaneous violation of most physiological functions of parenchymal organs, in which syndromes of cytolysis, cholestasis, immune and autoimmune disorders are simultaneously formed, the main role in which belongs to infectious (DNA/RNA viruses) and oncological processes. The most important biochemical markers in liver cancer are enzymes (AST, ALT, ALP, LDH, alpha-amylase), bilirubin, creatinine, albumin, triglycerides, GGTP, microelements (biogenic – magnesium, phosphorus, calcium). Among the viruses detected during liver cancer, the leading role belongs to viruses verified in tumor tissue, the presence of which causes persistent biochemical changes: VEB and HHV6.
Hybrid predictive maintenance model – study and implementation example
Authors: Wiercioch Jakub 
Published: September 2024

Abstract
In this paper, the concept of hybrid predictive maintenance for a single industrial machine is presented. A review of the solutions in the area of machine maintenance (especially predictive maintenance) which have been described in the literature is provided. The assumptions of the hybrid predictive maintenance model for modules, machines, or systems are presented. The methods used within the developed methodology are described. This includes the use of diagnostic data, experience, and a mathematical model. A case study of an industrial machine on which a system for collecting diag-nostic data has been pilot-implemented, using, among others, vibration sensors and drive system pa-rameters for damage detection is presented. The registered data can be used to precisely determine the time of upcoming failure after detection of the characteristic symptoms resulting from component wear In addition, an analysis of the durations of correct operation and failure events was performed and indicators describing these values were determined. The values of the aforementioned indicators were determined based on empirical data and described using a gamma distribution. The objective of the research was to prepare, implement and draw conclusions on a hybrid predictive maintenance model. A real industrial machine was used in the research study. The hybrid predictive maintenance model presented in this paper enables the use of data of different types (diagnostic, historical and mathemat-ical model-based) in scheduling machine downtime for maintenance actions. On the basis of the re-search conducted, it was determined which machine operating parameters are characterised by varia-bility that enables the detection of upcoming failure. This allows for precise planning of maintenance activities and minimization of unplanned downtime.
Management the efficiency of a photovoltaic installation
Authors: Cierlicki Tomasz , Zawada Marcin , Piasecka Izabela , Leda Patryk 
Published: September 2024

Abstract
A photovoltaic installation is a technical system consisting of several elements that determine the correct operation of the entire system. One of the most important elements of this system are photovoltaic panels consisting of photovoltaic cells. The highest efficiency of the photovoltaic system is achieved when the power generated by photovoltaic panels is the highest. The aim of the work is to investigate the influence of temperature and solar radiation intensity on the operation of a photovoltaic installation. Research shows that temperature and solar radiation intensity affect the power of a photovoltaic installation, so these parameters should be controlled in order obtaining the highest electricity.
Rapid assessment of solar PV micro-system energy generation in Poland based on freely pvlib-python library
Authors: Bień Jurand , Bień Beata 
Published: September 2024

Abstract
Poland has experienced a remarkable growth in renewable energy adoption, notably in photovoltaic (PV) solar systems. The majority of installations are prosumer PV micro-installations, exceeding predicted capacity targets outlined in the Energy Policy of Poland until 2040. Despite the significant growth in installed PV capacity, there is still a lack of comprehensive research focusing on fast assessment of energy generation capacity for solar PV micro-systems. This study aims to address this gap by providing a comprehensive analysis of energy production potential across different configurations and locations in Poland. Using geocoding techniques, solar irradiation data from PVGIS database and pvlib-python library, a methodology was developed to rapidly estimate energy generation from 1 kWp solar PV systems . Results reveal spatial disparities in energy yield from solar PV micro installations in Poland, influenced by factors such as geographical location and panel orientation and inclination. Recognizing that the presented energy indicators provide valuable initial parameters for determining solar PV system power output, this data can serve as a critical reference point for stakeholders, assisting them in estimating potential energy generation capacities in different regions of Poland.
Formation of Methane Hazards During Underground Coal Production in the Longwall Area Ventilated by System Y
Authors: Tutak Magdalena 
Published: September 2024

Abstract
The article addresses a critical and timely issue: improving safety in underground coal mining. The primary objective of the paper was to develop a research methodology based on modelling studies to identify and assess the state of methane hazards during mining operations. To achieve this, structural modelling of the physical and chemical phenomena occurring in mining regions was conducted using Computational Fluid Dynamics. The core research was performed using the finite volume method on a real longwall exploitation site ventilated by a Y-system. This approach enabled the determination of methane and oxygen concentration distributions in the mining region and goafs, treated as a porous and permeable medium. Based on these findings, potential fire and/or methane explosion hazard zones were identified in the goaf. The model test results underwent a validation process, comparing them with actual measurements. The determined errors were within an acceptable range, confirming the accuracy of the developed model of the mining region and the phenomena within it. Furthermore, the model was used to predict the locations of zones at risk of fire and/or methane explosion in the goafs, particularly in areas with potentially increased gas emissions. The results clearly demonstrate the significant potential of using model studies to diagnose and forecast methane hazards in underground mining operations. Identifying these potential danger zones allows for the implementation of preventive measures to reduce the likelihood of dangerous incidents.
Hakikat Manajemen Pendidikan Agama Islam Multikultural di Pesantren Multidimensi Al-Fakhriyah Makassar
Authors: Inayah Siti Nur Inayah , Yusuf Muhammad Yusuf 
Published: September 2024

This research was conducted at the Multidimensi Islamic boarding school of Al-Fakhriyah Makassar. This pesantren is a modern pesantren but does not leave the culture of Salafi style, which has diverse students from various tribes, races, ethnicities, social classes, different skin colors, and regional origins. As a result of this diversity, this pesantren must have good management. The purpose of this study is to explore and analyze the form of multicultural Islamic religious education management in the Multidimensi Islamic boarding school of Al-Fakhriyah Makassar. Researchers use qualitative research methods with a case study approach, data collection using participatory observation, structured and unstructured interviews, and documentation, and then the data is processed by analyzing it through an interactive model proposed by Miles and Huberman. The result of this study is that the management of multicultural Islamic religious education in the Multidimensi Islamic boarding school of Al-Fakhriyah Makassar runs quite effectively and efficiently; all activities are carried out well, and multicultural values have been seen, although there are still a handful of perpetrators of discrimination. According to researchers, this problem can be overcome by adding more supervision and attention and updating the management related to the organizing system.
Keywords: Management, Pesantrent, Multicultural.
PERAN KONSELING INDIVIDU DALAM MENGATASI PERILAKU MEMBOLOS SISWA MTs MUKHTAR SYAFA’AT BLOKAGUNG TEGALSARI BANYUWANGI
Authors: Afkarina Alfina Shofi , Mahmudah Mahmudah , Khaudli Muhammad Imam , Jauhariyah Nur Anim 
Published: September 2024

Ditching behavior is a form of juvenile delinquency that reflects student violations in school rules and regulations that will harm themselves and others, such as missing subject matter. The purpose of this study was to determine the forms, factors that encourage students to play truant as well as to determine the methods of guidance and counseling used by BK teachers based on the factors encountered. As understood, the impact of truancy behavior is failure in learning, failure in learning. The research method used in this research is qualitative. The subjects in this study were students of MTs Mukhtar Syafa'at Blokagung Banyuwangi. Data collection techniques in this study were interviews to obtain information about forms, factors, and methods of guidance and counseling, observations to obtain other information that supported the data obtained and documentation to obtain data including descriptions of schools and student development. The causes of truancy behavior are problems that come from self, family, school, and environmental factors with truant behavior, namely sleeping in the dormitory, hanging out in the shop, truant in certain subjects because they don't like the teacher and chatting when they meet their friends.
DAKWAH ISLAM PASCA WAFATNYA NABI MUHAMMAD SAW
Authors: Maskur Maskur , Abdi Fauji Hadiono  
Published: September 2024

Pasca Nabi Muhammad SAW wafat status sebagai Rasulullah tidak dapat diganti oleh siapapun, akan tetapi kedudukan Rasulullah SAW. Sebagai pemimpin kaum muslimin harus tergantikan. Peradaban Islam Periode Al-Khulafa’ Al-Rasyidin. Nabi Muhammad SAW wafat pada tanggal 12 Rabiulawal tahun 11 H atau tanggal 8 Juni 632 M. Sesaat setelah beliau wafat, situasi di kalangan umat Islam sempat kacau. Hal ini disebabkan Nabi Muhammad SAW tidak menunjuk calon penggantinya secara pasti. Dua kelompok yang merasa paling berhak untuk dicalonkan sebagai pengganti Nabi Muhammad SAW adalah kaum Muhajirin dan Anshar. Terdapat perbedaan pendapat antara kaum Muhajirin dan Anshar karena kaum Muhajirin mengusulkan Abu Bakar as Shiddiq, sedangkan kaum Anshar mengusulkan Sa’ad bin Ubadah sebagai pengganti nabi Muhammad SAW. Perbedaan pendapat antara dua kelompok tersebut akhirnya dapat diselesaikan secara damai setelah Umar bin Khatab mengemukakan pendapatnya. Selanjutnya, Umar menegaskan bahwa yang paling berhak memegang pimpinan sepeninggal Rasulullah adalah orang-orang Quraisy. Alasan tersebut dapat diterima oleh kedua belah pihak.
URGENSI LAYANAN BIMBINGAN DAN KONSELING SISWA DI SEKOLAH
Authors: Sa'diyah Kholifatus , Sunarto Sunarto 
Published: September 2024

Penelitian ini bertujuan untuk mengurai tentang urgensi bimbingan dan konseling di sekolah. Metode penelitian yang digunakan dalam penelitian ini adalah studi kepustakaan (library research). Proses penelitian kepustakaan pada penelitian ini digunakan untuk mengembangkan konsep dan masalah layanan konseling di sekolah, khususnya tentang urgensi bimbingan dan konseling di sekolah. Bimbingan dan konseling merupakan bagian integral yang tak dapat terpisahkan dari dunia pendidikan. Bimbingan dan konseling adalah bantuan konselor kepada klien untuk menemukan solusi atas masalah yang dihadapi klien dengan cara mengembangkan potensi yang dimiliki klien. Bimbingan konseling membantu siswa (klien), baik individu ataupun kelompok mengatasi masalah agar tercipta siswa yang mandiri yang dapat berkembang ke arah yang lebih baik. Selain itu, layanan bimbingan dan konseling tidak hanya mengembangkan potensi kemampuan siswa menuju kemandirian, melainkan juga sebagai pembentukan karakter siswa.
Analisis Penerapan Laporan Keuangan Berbasis Standar Akuntansi Keuangan – Entitas Mikro Kecil Menengah (SAK – EMKM) Pada UMKM Atebe Catering
Authors: Saghita Ghanis Noventa , Marlina Sari , Septiawati Rohma 
Published: September 2024

Usaha Mikro Kecil dan Menengah (UMKM) Merupakan salah satu kegiatan perekonomian yang dilakukan oleh sebagian besar penduduk Indonesia. Saat ini perkembangan bisnis di Indonesia semakin pesat, salah satu yang sedang berkembang di Indonesia adalah Usaha Mikro, Kecil dan Menengah (UMKM). Tujuan dari penelitian ini adalah untuk mengetahui bagaimana UMKM Atebe catering di Karawang Barat menerapkan pelaporan keuangan. Dalam observasi ini menggunakan model Miles dan Huberman. Penelitian menggunakan jenis Deskriptif – Kualitatif. Peneliti menyimpulkan bahwa meskipun laporan keuangan yang disusun oleh UMKM Atebe Catering sudah dilakukan, namun masih sederhana dan proses penyusunan laporan keuangannya masih manual dan berbeda secara signifikan dengan laporan keuangan yang diterapkan oleh standar akuntansi keuangan EMKM akibatnya, Informasi yang diperoleh dari catatan pelaporan keuangan yang dihasilkan mungkin tidak sepenuhnya mendukung atau berguna dalam pengambilan keputusan bisnis yang komprehensif. Penyusunan laporan SAK EMKM dapat memudahkan pengajuan dana ke pihak ketiga dan membedakan antara aset pribadi dan aset perusahaan yang di dirikan oleh entitas UMKM . Pentingnya pemerintah terlihat dari kegiatan sosialisasi yang diperlukan bagi para UMKM dalam mengetahui standar akuntansi keuangan UMKM.
PENGARUH JOB DEMAND TERHADAP KINERJA KARYAWAN YANG DIMEDIASI OLEH EMOTIONAL EXHAUSTION
Authors: Pusparini Rani , Herachwati Nuri , Mudzakkir Mohammad Fakhruddin 
Published: September 2024

Penelitian ini bertujuan untuk menganalisis pengaruh job demand terhadap kinerja karyawan yang dimediasi oleh emotional exhaustion atau kelelahan emosional pada instansi X. Peneliti menggunakan sebanyak 75 responden sebagai sampel dengan metode simple random sampling yang berarti setiap anggota populasi memiliki peluang yang sama menjadi sampel. Metode pengumpulan data dengan mengisi kuesioner yang menggunakan skala likert, serta penyebaran kuesioner dengan menggunakan Google Form. Teknik analisis data yang digunakan yaitu Structural Equation Modeling-Partial Least Square (SEM PLS) dengan menggunakan inner model dan outer model. Hasil penelitian ini menunjukkan bahwa 1) Job demand berpengaruh positif dan signifikan terhadap emotional exhaustion 2) Emotional exhaustion berpengaruh positif dan signifikan terhadap kinerja karyawan 3) Job demand berpengaruh positif dan signifikan terhadap kinerja karyawan 4) job demand berpengaruh positif dan signifikan terhadap kinerja karyawan yang dimediasi oleh emotional exhaustion.

Kata Kunci: Job Demand, Emotional Exhaustion, Kinerja Karyawan.
PERBANDINGAN STRATEGI PENGEMBANGAN SDM: PROGRAM MANAGEMENT TRAINEE DI PERUSAHAAN SWASTA DAN BADAN USAHA MILIK NEGARA
Authors: Mardela Hafilah Adys , Apriza Khalisya Nadine , Iswandi Muhammad Alwin , Almira Sazkia Ismi 
Published: September 2024

Program Management Trainee memegang peranan krusial dalam pengembangan SDM, terutama di Indonesia yang menekankan pada peningkatan kompetensi SDM. Peningkatan kompetensi SDM dapat dilakukan dengan diadakannya Program Management Trainee baik pada sektor publik maupun swasta. Penelitian ini menggunakan Teori Pengembangan SDM, Teori Management Trainee, dan Teori Perbedaan Antara Perusahaan Swasta dan BUMN dalam Pengembangan SDM. Dengan teori tersebut, esai ini bertujuan untuk menganalisis perbandingan pengembangan kompetensi yang dilakukan pada sektor publik dan swasta dalam program management trainee.

Kata Kunci: Sumber Daya Manusia, Kompetensi, Management Trainee.
EVALUASI PROGRAM TANGGUNG JAWAB SOSIAL PERUSAHAAN DALAM MANAJEMEN KEBENCANAAN PADA PABRIK SEMEN DI KABUPATEN BOGOR
Authors: Wibisono Widy , Sukwika Tatan , Sugiarto Sugiarto 
Published: September 2024

Sebagai bagian penting dari tanggung jawab sosial dan keberlangsungan usaha perusahaan maka perlu dilakukan kajian terkait pelaksanaan tanggap kebencanaan dengan berdasarkan kriteria yang ditetapkan dalam Permen LHK Nomor 1 Tahun 2021. Penelitian ini bertujuan untuk melihat keterlibatan perusahan dalam rangka responsivitas terhadap krisis atau bencana alam maupun non alam yang mencakup identifikasi kebutuhan dan permasalahan di masyarakat dalam kaitannya dengan siklus penanggulangan bencana, keterlibatan perusahaan dalam penanggulangan bencana, jangkauan wilayah program yang dilakukan oleh perusahaan, dan model kemitraan perusahaan dengan para stakeholder terkait penanggulangan bencana. Jenis data yang digunakan dalam penelitian ini adalah jenis data primer. Pengumpulan data primer dilakukan secara langsung oleh peneliti dengan melakukan observasi lapangan, mengumpulkan dokumen dan rekaman, serta wawancara secara langsung dengan karyawan yang berkompeten dan stakeholder terkait kebencanaan. Data yang telah diambil pada langkah sebelumnya kemudian dilakukan self assessment dengan menggunakan matriks penilaian yang disusun oleh Penulis untuk mendapatkan hasil penilaian tingkat penerapan saat ini dan ari hasil tersebut kemudian dilakukan analisa SWOT. Simpulan yang dapat diambil adalah hasil asesmen kinerja penanggulangan bencana perusahaan mendapatkan nilai 35 dari 50 yang berarti kinerja perusahaan masih dapat ditingkatkan. Kekuatan perusahaan terletak pada jaringan kemitraan yang cukup luas, kemampuan analisa risiko secara cepat, kemampuan tanggap darurat bencana di lingkup 12 desa mitra, sementara kelemahan perusahaan terlihat dari kurang maksimalnya peran organisasi tanggap darurat bencana yang telah dibentuk sehingga upaya yang dilakukan masih kurang fokus dan kurang dirasakan partisipasinya. Namun perusahaan berpeluang untuk memaksimalkan pemberdayaan sumber daya internal dan masyarakat serta jaringan yang cukup luas untuk menekan ancaman dari perusahaan lain khususnya industri sejenis dalam upaya penanggulangan bencana.
MANAJEMEN TEKNOLOGI: TINJAUAN PUSTAKA YANG SISTEMATIS
Authors: Saputro Dillyan Anugrah Joko , Herachwati Nuri , Choirunnisa Zuyyina 
Published: September 2024

Tinjauan literatur sistematis mengeksplorasi technostress dalam lingkungan kerja, terutama dalam lingkungan ekonomi dan bisnis. Stres, yang digambarkan sebagai tekanan mental yang memengaruhi individu sepanjang hidup mereka, secara khusus menyoroti stres kerja dan konsekuensinya yang parah—masalah kesehatan fisik/mental, penurunan kepuasan kerja, tingkat pergantian yang lebih tinggi, dan tingkat ketidakhadiran. Di sisi lain, tinjauan ini berfokus pada dampak kepuasan TI terhadap hasil perilaku, dengan menekankan kaitannya yang kurang dieksplorasi dengan sikap terkait pekerjaan. Bagian ini merinci penyebab, jenis, dan dampak technostress pada produktivitas dan kelelahan. Ini menguraikan berbagai studi, mengkategorikan, dan mengevaluasi tingkat dan jenis technostress dalam konteks faktor pribadi dan lingkungan. Selain itu, tinjauan ini mendalami faktor-faktor yang memengaruhi keseimbangan kerja-rumah. Akhirnya, dibahas dampak ganda teknologi—memungkinkan fleksibilitas tetapi menyebabkan jam kerja yang lebih panjang, kontak terus-menerus, dan pengurangan pelepasan dari pekerjaan. Bagian selanjutnya berencana untuk fokus pada metode, hasil, dan diskusi dari studi terbaru selama lima tahun terakhir untuk menganalisis faktor-faktor awal dalam manajemen technostress.

Kata Kunci: Technostress, Manajemen Technostress, Technostressor.