bluuebunny/crossref_metadata_2025_split huggingface dataset:
An open resource for nonhuman primate imaging
Authors: Milham Michael P. , Ai Lei , Koo Bonhwang , Xu Ting , Balezeau Fabien , Baxter Mark G. , Croxson Paula L. , Damatac Christienne G. , Harel Noam , Freiwald Winrich , Griffiths Timothy D. , Everling Stefan , Jung Benjamin , Kastner Sabine , Leopold David A. , Mars Rogier B. , Menon Ravi S. , Messinger Adam , Morrison John H. , Nacef Jennifer , Nagy Jamie , Rios Michael Ortiz , Petkov Christopher I. , Pinsk Mark , Poirier Colline , Rajimehr Reza , Rushworth Matthew F.S , Russ Brian E. , Schmid Michael , Schwiedrzik Caspar M. , Sallet Jerome , Seidlitz Jakob , Ungerleider Leslie , Thiele Alexander , Tsao Doris , Yacoub Essa , Ye Frank , Zarco Wilbert , Margulies Daniel S. , Schroeder Charles 
Published: December 2017

ABSTRACTNon-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience.Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMate Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 13 independent data collections aggregated across 11 sites (total = 98 macaque monkeys). We also outline the unique pitfalls and challenges that should be considered in the analysis of the non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets.
Effects of the Medicare Modernization Act on Spending for Outpatient Surgery
Authors: Hollingsworth John M. , Oerline Mary K. , Ellimoottil Chandy , Herrel Lindsey A. , Hollenbeck Brent K. 
Published: December 2017

ObjectivesTo examine the effects of Medicare's revised ambulatory surgery center (ASC) payment schedule on overall payments for outpatient surgery.Data SourcesTwenty percent sample of national Medicare beneficiaries.Study DesignWe conducted a pre–post study of Medicare beneficiaries who underwent outpatient surgery in a hospital outpatient department (HOPD), ASC, or physician office between 2004 and 2011. Specifically, we used multivariable regression to compare temporal trends in outpatient surgery before and after implementation of Medicare's revised payment schedule in 2008, which reduced ASC facility payments to roughly two‐thirds that of HOPDs. Our outcome measures included overall Medicare payments, utilization rates, per beneficiary spending, and average episode payments for outpatient surgery.Principal FindingsBetween the last quarters of 2007 and 2008, overall Medicare payments for outpatient surgery grew by $334 million—an amount nearly three times higher than would have been expected without the policy change (p < .001 for the difference). While utilization rates of outpatient surgery were attenuated, per beneficiary spending and average surgical episode payments increased by 10.4 percent and 7.8 percent, respectively, over the same period. By the end of 2011, Medicare payments for outpatient surgery reached $5.1 billion. Without the policy change, they would have totaled only $4.1 billion.ConclusionsDespite lessening demand, reduced ASC facility payments did not curb spending for outpatient surgery. In fact, overall payments actually increased following the policy change, driven by higher average episode payments.
Development and Validation of a Short‐Form Safety Net Medical Home Scale
Authors: Nocon Robert S. , Gunter Kathryn E. , Gao Yue , Lee Sang Mee , Chin Marshall H. 
Published: December 2017

ObjectiveTo develop a short‐form Safety Net Medical Home Scale (SNMHS) for assessing patient‐centered medical home (PCMH) capability in safety net clinics.Data Sources/Study SettingNational surveys of federally qualified health centers (FQHCs). Interviews with FQHC directors.Study DesignWe constructed three short‐form SNMHS versions and examined correlations with full SNMHS and related primary care assessments. We tested usability with FQHC directors and reviewed scale development with an advisory group.Data CollectionFederally qualified health center surveys were administered in 2009 and 2013, by mail and online. Usability testing was conducted through telephone interviews with FQHC directors in 2013.Principal FindingsSix‐, 12‐, and 18‐question short‐form SNMHS versions had Pearson correlations with full scale of 0.84, 0.92, and 0.96, respectively. All versions showed a level of convergent validity with other primary care assessment scales comparable to the full SNMHS. User testers found short forms to be low‐burden, though missing some PCMH concepts. Advisory group members expressed caution over missing concepts and appropriate use of short‐form self‐assessments.ConclusionsShort‐form versions of SNMHS showed strong correlations with full scale and may be useful for brief assessment of safety net PCMH capability. Each short‐form SNMHS version may be appropriate for different research, quality improvement, and assessment purposes.
Contribution of Histidine and Lysine to the Generation of Volatile Compounds in Jinhua Ham Exposed to Ripening Conditions Via Maillard Reaction
Authors: Zhu Chao‐Zhi , Zhao Jing‐Li , Tian Wei , Liu Yan‐Xia , Li Miao‐Yun , Zhao Gai‐Ming 
Published: December 2017

AbstractTo evaluate the role of Maillard reactions in the generation of flavor compounds in Jinhua ham, the reactions of glucose and ethanal with histidine and lysine, respectively, were studied by simulating the ripening conditions of Jinhua ham. The volatile products produced were analyzed using solid phase microextraction‐gas chromatography/mass spectrometry. The results showed that 8 volatile compounds were generated by the reaction of glucose and histidine and 10 volatile compounds were generated by the reaction of glucose and lysine. Reactions of ethanal with lysine and with histidine both generated 31 volatile compounds that contributed to the flavor of Jinhua ham. This indicates that histidine and lysine related to Maillard reactions possibly play important roles in the generation of the unique flavor compounds in Jinhua ham. This research demonstrates that free amino acids participate in the generation of volatile compounds from Jinhua ham via the Maillard reaction and provides a basic mechanism to explain flavor formation in Jinhua ham.Practical ApplicationJinhua ham is a well‐known traditional Chinese dry‐cured meat product. However, the formation of the compounds comprising its special flavor is not well understood. Our results indicate that Maillard reactions occur in Jinhua ham under ripening conditions. This work illustrates the contribution of Maillard reactions to the flavor of Jinhua ham.
Rescue excavation of a third‐millennium BC tomb at Al‐Khubayb, Sultanate of Oman
Authors: Döpper Stephanie 
Published: December 2017

AbstractA third‐millennium BC tomb was subject to a rescue excavation in connection with the construction of a new road near the village of Al‐Khubayb in the Sultanate of Oman. It yielded a small number of finds, especially small metal objects that belonged to a later reuse of the tomb in the Samad period. As all diagnostic finds from the tomb date to the reuse, its architectural elements were the only indicator for the construction date of the tomb. Besides its small size and large wall thickness, which might suggest that the tomb is a transitional type between the Hafit and the Umm an‐Nar periods, its separation into two chambers and its facade made of white, dressed stones, can be seen as a clue for a construction date of the tomb in the Umm an‐Nar period.
The Dynamic Nature of Self‐Assessed Health (SAH) as a Function of Negative and Positive Affects among Cardiac Patients
Authors: Peleg Shira , Drori Erga , Banai Shmuel , Finkelstein Ariel , Shiloh Shoshana 
Published: December 2017

BackgroundSelf‐assessed health (SAH) predicts health outcomes above and beyond medical variables. One of the explanations for this robust finding is the sensitivity of SAH to changes in multiple aspects of health, including emotional factors. We assessed the dynamic nature of SAH by longitudinally examining the associations between initial and change levels of SAH and positive affect (PA) and negative affect (NA).MethodsParticipants were 138 cardiac patients undergoing coronary angioplasty. Self‐report questionnaires measured SAH, PA, and NA, one day and one month after catheterisation.ResultsMeans of SAH and NA did not change between measurement points, but PA decreased. Cross‐lagged analysis indicated that the best model for representing the data included a path from affect at hospitalisation to SAH one month later; that is, lower NA (but not PA) at hospitalisation predicted higher SAH a month later. A latent change model analysis also revealed that NA (but not PA) at hospitalisation predicted changes in SAH (but SAH did not predict changes in negative or positive affect); and that increases in positive affect and decreases in negative affect were linked to increases in SAH.ConclusionsThese findings highlight the importance of NA as an indicator of SAH and SAH change, and provide further insights into the dynamics of SAH in cardiac patients.
Strong but taxon‐specific responses of termites and wood‐nesting ants to forest regeneration in Borneo
Authors: Kimber Annie , Eggleton Paul 
Published: December 2017

AbstractLand use change is accelerating globally at the expense of biodiversity and ecosystem functioning. Invertebrates are numerically dominant and functionally important in old growth tropical rain forests but highly susceptible to the adverse effects of forest degradation and fragmentation. Ants (Formicidae) and termites (Blattodea: Termitoidae) perform crucial ecosystem services. Here, the potential effects of anthropogenic disturbance on ant and termite communities in dead wood are investigated. Community composition, generic richness, and occupancy rates of ants and termites were compared among two old growth sites (Danum Valley and Maliau Basin) and one twice‐logged site (the Stability of Altered Forest Ecosystems’ (SAFE) Project), in Sabah, Malaysian Borneo. Occupancy was measured as the number of ant or termite encounters (1) per deadwood items, and (2) per deadwood volume, and acts as surrogates for relative abundance (or generic richness). Termites had a lower wood‐occupancy per volume in logged forest. In contrast, there were more ant encounters, and more ant genera, in logged sites and there was a community shift (especially, there were moreCrematogasterencounters). The disruption of soil and canopy structure in logged forest may reduce both termite and fungal decay rates, inducing increased deadwood residence times and therefore favoring ants that nest in dead wood. There is an anthropogenic‐induced shift of dead wood in ants and termites in response to disturbance in tropical rain forests and the nature of that shift is taxon‐specific.
The futures of Canadian governance: Foresight competencies for public administration in the digital era
Authors: Jones Peter 
Published: December 2017

AbstractEvidence‐based practice has advanced in public administration, with increasing reliance on social research and population sampling in decision making. Yet the evidence‐based turn risks marginalizing the value of strategic foresight and futures competencies in informing policy and planning. Where evidence enables policymakers to select the best near‐term course of action, future outcomes are inferred and projected, and not determined by past evidence. Foresight provides a necessary competency for defining and investing in the right direction of future policy and action, by articulating future problematics with multiple foresight methods. While social and technological futures cannot be precisely predicted, future scenarios and prospectuses can be designed to inform options and trajectories for intervention and new policy. The emerging area of digital‐era governance is examined, where complex scenarios for future policies are based on present evidence (such as trends) and informed speculation to formulate policies and options in dynamically changing societal contexts.
Regional distribution patterns can predict the local habitat specialization of arachnids in heterogeneous landscapes of the Atlantic Forest
Authors: Porto Tiago Jordão , Pinto‐da‐Rocha Ricardo , da Rocha Pedro Luís Bernardo 
Published: December 2017

AbstractAimThis study formally evaluates the ability of three models to use geographical data on species distribution to predict the habitat use patterns of species in heterogeneous landscapes.LocationSpecies and habitats in the Brazilian Atlantic Rain Forest were investigated.MethodsBased on empirical data on harvestmen and scorpions, we estimated the strength of species association with preferred habitat and classified them as habitat generalists or habitat specialists. We compared these empirical results with predictions made using data on species range size (model 1), species occurrence in biomes (model 2) and species occurrence in habitats within the biomes (model 3).ResultsWe used 1,278 records of eight harvestman and two scorpion species that had specific determination and enough sampling numbers to allow safe identification of habitat specialization. We observed the following: (1) the extension of species occurrence did not influence the strength of species–habitat association (estimated by IndVal), which led us to reject model 1; (2) species habitat specialization derived from occurrences in biomes was 60% coincident with the classification derived from empirical data. This value is not different enough from the value expected by chance for these data, which also led us to reject model 2; and (3) species classification derived from secondary data about the habitats used had a significant coincidence of 80% with the empirical classification, which led us to accept model 3.Main conclusionsFor correct classification of species habitat specialization using secondary distributional data, we recommend that future studies consider using the most accurate information available on the habitats used by species. Especially for megadiverse and understudied groups, information about habitats used is not easy to obtain, so it is important for researchers and institutions to register and disseminate this information, which could support many other studies.
The role of sclerostin/dickkopf‐1 and receptor activator of nuclear factor kB ligand/osteoprotegerin signalling pathways in the development of osteoporosis in patients with haemophilia A and B: A cross‐sectional study
Authors: Anagnostis P. , Vakalopoulou S. , Christoulas D. , Paschou S. A. , Papatheodorou A. , Garipidou V. , Kokkoris P. , Terpos E. 
Published: December 2017

AimHaemophilia A and B are associated with reduced bone mineral density (BMD). The aim of this study was to assess circulating sclerostin and dickkopf‐1 (Dkk‐1), (inhibitors of osteoblastic differentiation), as well as the receptor activator of nuclear factor kB ligand (RANKL)/osteoprotegerin (OPG) system (the major regulator of osteoclastogenesis), in patients with haemophilia (PWH), their possible correlations with clinical risk factors and the effect of ibandronate on these markers.MethodsEighty‐nine malePWH(mean age 45.9 ± 15.3 years) and 30 age‐matched healthy male controls participated.BMDwas assessed byDXA. Sclerostin, Dkk‐1,RANKLandOPGwere measured in serum of patients, controls, as well as in ten patients receiving oral ibandronate (150 mg/mo), at baseline and after 12 months.ResultsPatients with haemophilia had lower circulating sclerostin (median ± IQR: 47.4 ± 26.93 vs 250 ± 250 pmol/L,P < .001), Dkk‐1 (21.24 ± 17.18 vs 26.16 ± 15.32pg/mL,P = .04) and higher levels ofRANKL(0.23 ± 0.03 vs 0.04 ± 0.03 pmol/L,P = .001),RANKL/OPGratio (0.063 ± 0.25 vs 0.005 ± 0.11,P = .001) compared with controls. Patients with lowBMDhad higherOPGconcentrations compared to those with normalBMD. Sclerostin andRANKL/OPGcorrelated positively withBMD. Patients with severe haemophilia had lower sclerostin concentrations compared with those with mild or moderate disease. The degree of arthropathy negatively correlated with sclerostin and Dkk‐1 levels.PWHwho received ibandronate showed a decrease in serum Dkk‐1 without any significant effect on sclerostin andRANKL/OPG.ConclusionsPatients with haemophilia present increased osteoclastic activity coupled with compensatory increased osteoblastic activity. Ibandronate did not affectRANKL/OPGratio, but it decreased Dkk‐1.
A multiobjective approach for maximizing the reach or GRP of different brands in TV advertising
Authors: Evangelista Vivian M. , Regis Rommel G. 
Published: December 2017

AbstractThis paper focuses on a multiobjective optimization problem in TV advertising from an advertising agency's perspective, which involves deciding on which commercial breaks to air the ads of various brands to jointly maximize reach or gross rating point (GRP) for the different brands subject to budget constraints, brand competition constraints, and other scheduling constraints. We present a multiobjective integer programming formulation of this problem and develop and implement algorithms for generating provably Pareto‐optimal solutions. We also develop reduction and visualization procedures to aid a decision maker in choosing suitable subsets of the Pareto‐optimal solutions obtained. Numerical experiments on five TV advertising problems involving 20–40 objective functions and thousands of decision variables and constraints demonstrate the effectiveness of the proposed formulation and solution methods in generating Pareto‐optimal objective vectors that reflect brand priorities and that are well distributed along the Pareto front.
Great ape nutrition: low‐sugar and high‐fibre diets can lead to increased natural behaviours, decreased regurgitation and reingestion, and reversal of prediabetes
Authors: Cabana F. , Jasmi R. , Maguire R. 
Published: December 2017

Great apes in captivity have been affected by a variety of conditions, including obesity, heart, gastrointestinal and dental diseases, and diabetes, all of which are at least influenced by an inappropriate diet. ‘Regurgitation and reingestion’ is also related to diet in great apes. Diets tend to be high in water‐soluble carbohydrates (WSC) (e.g. sugars and starches) and low in fibre. This study aimed to reduce the WSC and increase fibre concentrations of great ape diets, most notably for Chimpanzees Pan troglodytes, Bornean orangutans Pongo pygmaeus, Sumatran orangutans Pongo abelii and hybrid orangutans, and Western lowland gorillas Gorilla gorilla gorilla, and evaluate the behavioural and physiological responses of these species to the dietary changes. Wildlife Reserves Singapore had 4.8 Chimpanzees, 10.5 Bornean orangutans, 5.3 Sumatran orangutans and 2.1 P. pygmaeus × P. abelii orangutan hybrids, and Longleat Safari and Adventure Park, UK, had 4.0 Western lowland gorillas. Behaviour was recorded via scan sampling throughout the diet‐change process with a gradual decline in WSC. Five orangutans and two Chimpanzees were conditioned for finger pricking to monitor their blood‐glucose concentrations. The new diets led to changes in WSC from 59·0–64·3% to 47·5–47·7% and in neutral detergent fibre from 11·5–14·4% to 15·7–22·9% on a dry‐matter basis. These dietary changes significantly increased ‘travelling’, ‘foraging’ and ‘social affiliative’ behaviours, and decreased ‘inactivity’ and ‘abnormal behaviour patterns’, such as ‘regurgitation and reingestion’. Fasting blood glucose also decreased and, eventually, all great apes sampled had average blood‐glucose levels. Orangutans had a stronger insulin response compared with Chimpanzees, which may reflect their feeding ecology.
Disentangling sex allocation in a viviparous reptile with temperature‐dependent sex determination: a multifactorial approach
Authors: Gruber J. , Cunningham G. D. , While G. M. , Wapstra E. 
Published: December 2017

AbstractFemales are predicted to alter sex allocation when ecological, physiological and behavioural variables have different consequences on the fitness of male and female offspring. Traditionally, tests of sex allocation have examined single causative factors, often ignoring possible interactions between multiple factors. Here, we used a multifactorial approach to examine sex allocation in the viviparous skink,Niveoscincus ocellatus. We integrated a 16‐year observational field study with a manipulative laboratory experiment to explore whether the effects of the maternal thermal environment interact with the resources available to females for reproduction to affect sex allocation decisions. We found strong effects of temperature on sex allocation in the field, with females born in warm conditions and males in cold conditions; however, this was not replicated in the laboratory. In contrast, we found no effect of female resource availability on sex allocation, either independently, or in interaction with temperature. These results corresponded with an overall lack of an effect of resource availability on any of the life history traits that we predicted would mediate the benefits of differential sex allocation in this system, suggesting that selection for sex allocation in response to resource availability may be relatively weak. Combined, these results suggest that temperature may be the predominant factor driving sex allocation in this system.
Nanoemulsion from essential oil of Pterodon emarginatus (Fabaceae) shows in vitro efficacy against monogeneans of Colossoma macropomum (Pisces: Serrasalmidae)
Authors: Valentim D S S , Duarte J L , Oliveira A E M F M , Cruz R A S , Carvalho J C T , Conceição E C , Fernandes C P , Tavares‐Dias M 
Published: December 2017

AbstractOutbreaks of diseases pose a major threat to sustainable aquaculture development worldwide. Application of herbal products to combat parasitic diseases provides an alternative approach for sustainable aquaculture. This study investigated the in vitro antiparasitic effects of an oil‐in‐water nanoemulsion prepared using the essential oil from Pterodon emarginatus, against monogeneans infesting Colossoma macropomum. Gill arches from C. macropomum (47.6 ± 14.5 g and 13.5 ± 1.4 cm) that were naturally parasitized by Anacanthorus spathulatus, Notozothecium janauachensis and Mymarothecium boegeri were immersed in different dispersions of the P. emarginatus nanoemulsions (0, 50, 100, 200, 400 and 600 mg/L). The major compounds presented in the essential oil of P. emarginatus were β‐elemene, β‐caryophyllene and α‐humulene. Characterization of these nanoemulsions showed that they have a small mean droplet size and low polydispersity index, which is concordant with stable systems. In this in vitro trial, the P. emarginatus nanoemulsion concentrations of 100, 200, 400 and 600 mg/L presented 100% helminthic efficacy against monogeneans of the gills of C. macropomum. The highest two concentrations used (400 and 600 mg/L) were seen to immobilize the parasites after only 15 min. Therefore, it would be worthwhile testing these concentrations in therapeutic baths against monogeneans of C. macropomum.