bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Basic Needs in Games Model of Video Game Play and Mental Health
Authors: Ballou Nick , Deterding Sebastian 
Published: October 2024

Abstract
Existing theories of how game use relates to mental health have important limitations: few account for both quantity and quality of use, differentiate components of mental health (hedonic wellbeing, eudaimonic wellbeing and illbeing), provide an explanation for both positive and negative outcomes or readily explain the well-evidenced absence of playtime effects on mental health. Many also lack the specificity to be readily falsifiable. In response, we present the Basic Needs in Games (BANG) model. Grounded in self-determination theory, BANG proposes that mental health outcomes of game use are in large part mediated by the motivational quality of play and the extent to which play quantity and quality lead to need satisfaction or frustration. We show how BANG addresses the limitations of current theories and aligns with emerging evidence on the etiologies of disordered play. Thus, BANG advances HCI theory on the impact of games and other interactive technologies on mental health.
Seismic trace interpolation based on the principle of reciprocity using a conditional generative adversarial network (cGAN)
Authors: Collazos Jaime A , Rincon Katerine D J , Pinheiro Daniel N , Gebre Mesay Geletu , da Costa Carlos A N , Corso Gilberto , Barros Tiago , de Araújo Joao Medeiros , Wang Yanghua 
Published: October 2024

Abstract
Seismic trace interpolation is a common step in data processing used to fill in missing traces and regularize acquisition grids. In the ocean bottom node (OBN) acquisition, it is common practice to design seismic surveys with many sources and fewer receivers. However, it results in a loss of lateral resolution in the shot-gather domain, although it increases the lateral resolution in the receiver-gather domain. In this paper, we propose to utilize the information from the receiver-gather domain to enhance the lateral resolution in the shot-gather domain, based on the principle of reciprocity. Explicitly, we use receiver gathers to train a conditional generative adversarial network (cGAN), called Pix2Pix, and obtain a generative interpolator, which can be used in the shot-gather domain. We present an iterative workflow to perform seismic data interpolation in the shot-gather domain and illustrate the workflow using a synthetic 2D data model consisting of densely populated sources and sparse receivers. We also present a field OBN data example from a Brazilian pre-salt area. The workflow can be used to increase lateral resolution or even complete the geometry of a monitor acquisition to match the baseline. In contrast to conventional methods, this iterative GAN interpolation does not lead to artefacts in the case of larger filling gaps.
Effect of pharmacist interventions in chronic kidney disease: a meta-analysis
Authors: Ardavani Ashkon , Curtis Ffion , Hopwood Ellen , Highton Patrick , Katapa Priscilla , Khunti Kamlesh , Wilkinson Thomas J 
Published: October 2024

ABSTRACT

Background
Pharmacists are uniquely placed with their therapeutic knowledge to manage people with chronic kidney disease (CKD). Data are limited regarding the impact of pharmacist interventions on economic, clinical and humanistic outcomes (ECHO).

Methods
A systematic review and meta-analysis of randomized controlled trials (RCTs) of interventions with pharmacist input was conducted, which included adults with a diagnosis of CKD, including those with and without kidney replacement therapy. Data were extracted on ECHO: economic (e.g. healthcare-associated costs), clinical (e.g. mortality) and humanistic (e.g. patient satisfaction) outcomes. Where appropriate, a random-effects model meta-analysis generated a pooled estimate of effect. A direction of effect plot was used to summarize the overall effects for clinical outcome domains.

Results
Thirty-two RCTs reported a total of 10 economic, 211 clinical and 18 humanistic outcomes. Pharmacist interventions resulted in statistically significant improvements in systolic blood pressure and hemoglobin levels, but not in diastolic blood pressure, estimated glomerular filtration rate, creatinine and low-density lipoprotein cholesterol levels. Mixed findings were reported for clinical and economic outcomes, whilst pharmacist interventions resulted in an improvement in humanistic outcomes such as patient satisfaction and patient knowledge.

Conclusion
Findings showed pharmacist interventions had mixed results for various outcomes. Future studies should be more robustly designed and take into consideration the role of the pharmacist in prescribing and deprescribing, the findings of which will help inform research and clinical practice.

Trial registration
The review was prospectively registered on PROSPERO (CRD42022304902).
Subjective Perceptions of Difference in Multi-level States: Regional Values, Embeddedness, and Bias in Canadian Provinces
Authors: Henderson Ailsa , Bilodeau Antoine , Turgeon Luc , White Stephen E 
Published: October 2024

Abstract
Subnational variations in political culture and policy attitudes are a hallmark feature of multilevel systems of government, yet we know comparatively little about how and why citizens of these systems subjectively perceive regional differences in political values. Using data from a specially commissioned survey under the auspices of the Provincial Diversity Project, this article analyses subjective perceptions of difference across provinces in Canada. It shows that individuals believe their regions have distinct political values, but also that they systematically overestimate that difference. In their estimations of regional distinctiveness, individuals are informed by the value profiles of the regions in which they live, but also by their own policy preferences. The findings clarify the salience of internal boundaries within multilevel or federal states, and enable us to understand how myths of distinctiveness flourish, but also provide an important extension on debates about misperceptions in politics.
It’s not (only) personal, it’s business: personal bankruptcy exemptions and business credit
Authors: Cole Rebel A , Damm Jason , Hackney John , Suleymanov Masim 
Published: October 2024

Abstract
In the USA, state-level exemptions determine the amount of property that individuals can protect from creditor liquidation during the debt settlement process. We exploit within-metropolitan statistical area variation in personal bankruptcy exemptions created by state borders and a stacked regression approach to identify the spillover effects of these laws on business credit extended to small firms. Subsequent to exemption increases, we find a reduction of 1–2 percent in originations of business credit. The effect is strongest for the smallest firms, which are more financially constrained. We provide household-level evidence that both business debt and personal debt decline for borrowers whose home equity becomes covered by the exemption, suggesting an overall decrease in credit availability for small businesses. As a result, increases in exemptions lead to fewer small establishments and lower employment, especially in industries dependent on external finance, suggesting that negative real economic effects occur via a credit market channel.
Comparing Refugee Resettlement Services: A New Global Dataset and Typology
Authors: Benson Grace E K 
Published: October 2024

Abstract
The number of countries participating in resettlement has increased substantially in recent years: since 2010, one-third of resettlement countries officially began offering permanent homes to refugees. The services provided to refugees upon resettlement are surprisingly distinct, even among countries with similar political and economic contexts. Despite the importance of these services, existing scholarship offers surprisingly little comparison of resettlement policies globally. To address this gap, this multi-method project analyses refugee resettlement services in 26 countries that are responsible for 99.9 per cent of all resettled refugees, from 1951 to present. The study introduces an original Global Resettlement Services dataset with 42 indicators that provide a current, reliable, and easily accessible overview of resettlement services in each country. Cluster analysis of these data helped to construct a typology that captures four distinct “types” of refugee resettlement: Limited Provision, Cultural Transition, Core Services, and Flexible Support. The typology provides a framework to help policy-makers, academics, and practitioners increase collaboration, design innovative programmes, and improve existing resettlement services. This study offers a comprehensive analysis of the different approaches to resettling refugees worldwide, with significant implications for advancing theory and improving global refugee resettlement policies.
Is sexual function impaired in patients with primary headaches? A systematic review of observational studies
Authors: Ataş Kübra , Kaya Mutlu Ebru 
Published: October 2024

Abstract

Introduction
Primary headaches, particularly migraine and tension-type headaches, as chronic and painful conditions, have a significant impact on individuals’ health and overall quality of life, including aspects such as sexual health parameters.

Objectives
The aim of this study was to review observational studies and to summarize the presence of sexual dysfunction in patients with primary headache and to discern whether it is more common in patients with primary headache than in healthy control subjects.

Methods
Observational studies published between January 1, 2000, and May 21, 2023 were searched in Medline (PubMed), Web of Science, Scopus, and EBSCO. This review included 23 observational studies that evaluated sexual dysfunction with or without comparison with healthy control subjects.

Results
As a result, the mean Female Sexual Function Index score, a score of &lt;26.55 indicating sexual dysfunction, ranged from 19.25 ± 8.18 to 27.5 ± 7.5 in patients with primary headache. The prevalence of sexual dysfunction and erectile dysfunction was found to be between 10.7% and 93.75% in female patients and between 54.83% and 80% in male patients. Both migraineurs and tension-type headache sufferers had statistically significantly lower sexual function scores in females and lower erectile function scores in males compared with healthy control subjects.

Conclusion
Sexual function is significantly affected in patients with primary headache, which is a chronic painful disorder. Therefore, it is very important to ask these patients about their sexual health and, if necessary, to seek support from a sexual health professional. Additionally, future studies may prioritize tension-type headaches and male patients due to the limited amount of research available on these subjects.
Embolism propagation does not rely on pressure only: time-based shifts in xylem vulnerability curves of angiosperms determine the accuracy of the flow-centrifuge method
Authors: Silva Luciano M , Pfaff Jonas , Pereira Luciano , Miranda Marcela T , Jansen Steven 
Published: October 2024

Abstract
Centrifuges provide a fast approach to quantify the embolism resistance of xylem in vulnerability curves (VCs). Since embolism formation is assumingly driven by pressure only, spintime is not standardized for flowcentrifuge experiments. Here, we explore to what extent embolism resistance could be spin-time dependent and hypothesize that changes in hydraulic conductivity (Kh) would shift VCs towards higher water potential (Ψ) values over time. We quantified time-based shifts in flow-centrifuge VCs and their parameter estimations for six angiosperm species by measuring Kh over 15 min of spinning at a particular speed before a higher speed was applied to the same sample. We compared various VCs per sample based on cumulative spintime and modelled the relationship between Kh, Ψ and spin-time. Time-based changes of Kh showed considerable increases and decreases at low and high centrifuge speeds, respectively, which generally shifted VCs towards more positive Ψ values. Values corresponding to 50% loss of hydraulic conductivity (P50) became less negative by up to 0.72 MPa in Acer pseudoplatanus L., and on average by 8.5% for all six species compared with VCs that did not consider spin-time. By employing an asymptotic exponential model, we estimated time-stable Kh, which improved the statistical significance of VCs in five of the six species studied. This model also revealed the instability of VCs at short spin times with embolism formation in flowcentrifuges following a saturating exponential growth curve. Although pressure remains the major determinant of embolism formation, spin-time should be considered in flow-centrifuge VCs because not considering the time-dependent stability of Kh overestimates embolism resistance. This spin-time artefact is species-specific and likely based on relatively slow gas diffusion that is associated with embolism propagation. The accuracy of VCs is improved by determining time-stable Kh values for each centrifuge speed without considerably extending the experimental time to construct VCs.
Protamine Dosing for Heparin Reversal after Cardiopulmonary Bypass: A Double-blinded Prospective Randomized Control Trial Comparing Two Strategies
Authors: Jain Pankaj , Silva-De Las Salas Alejandra , Bedi Kabir , Lamelas Joseph , Epstein Richard H. , Fabbro Michael 
Published: October 2024

Background:
Drug shortages are a frequent challenge in current clinical practice. Certain drugs (e.g., protamine) lack alternatives, and inadequate supplies can limit access to services. Conventional protamine dosing uses heparin ratio-based calculations for heparin reversal after cardiopulmonary bypass and may result in excess protamine utilization and potential harm due to its intrinsic anticoagulation. This study hypothesized that a fixed 250-mg protamine dose would be comparable, as measured by the activated clotting time, to a 1:1 (1 mg for every 100 U) protamine-to-heparin ratio-based strategy for heparin reversal and that protamine would be conserved.

Methods:
In a single-center, double-blinded trial, consenting elective adult cardiac surgical patients without preexisting coagulopathy or ongoing anticoagulation and a calculated initial heparin dose greater than or equal to 27,500 U were randomized to receive, after cardiopulmonary bypass, protamine as a fixed dose (250 mg) or a ratio-based dose (1 mg:100 U heparin). The primary outcome was the activated clotting time after initial protamine administration, assessed by Student’s t test. Secondary outcomes included total protamine, the need for additional protamine, and the cumulative 24-h chest tube output.

Results:
There were 62 and 63 patients in the fixed- and ratio-based dose groups, respectively. The mean postprotamine activated clotting time was not different between groups (−2.0 s; 95% CI, −7.2 to 3.3 s; P = 0.47). Less total protamine per case was administered in the fixed-dose group (−2.1 50-mg vials; 95% CI, −2.4 to −1.8; P < 0.0001). There was no difference in the cumulative 24-h chest tube output (difference, −77 ml; 95% CI, 220 to 65 ml; P = 0.28).

Conclusions:
A 1:1 heparin ratio-based protamine dosing strategy compared to a fixed 250-mg dose resulted in the administration of a larger total dose of protamine but no difference in either the initial activated clotting time or the amount postoperative chest-tube bleeding.
Effective use of actifuse shape in spinal fusion: A retrospective chart review
Authors: Schlifka Brett Alan , Milam Robert Alden , Saliba Denise , Parreno Rhea , Morone Pinto Flavia 
Published: October 2024

Introduction:
This study aimed to assess the safety and clinical performance of Actifuse Shape for spine surgery.

Method:
A retrospective real-world data study was conducted in two research sites in the U.S. Patient medical records had to show evidence of implantation with Actifuse Shape in 1-2 levels or 2 or more levels cervical (C2 or lower), in either posterolateral thoraco-lumbar or lumbar spine fusion procedures, among other eligibility criteria. All fusion assessments were completed using the Glassman 5 grade fusion scale.

Results:
Fifty-five (55) medical records were included in the full analysis set, and of these, 42 were eligible, achieving 97.6% bone fusion with a 95% CI (87.4%, 99.9%). Fusion success rates (Grade 4 or 5): 6 mo 72.7% (n=8/11), 12 mo 97.6% (n=41/42) and 24 mo 100% (n=49/49). No device-related adverse events were reported for Actifuse Shape. A “worst-case” imputation post hoc analysis was performed to take into account five patients who did not show evidence of fusion at 6 mo and were lost to follow up and were assumed to continue showing no evidence of fusion throughout the remaining study period. Forty-one out of 47 (87.2%) patients (95% CI: 74.3, 95.2) achieved successful fusion at 12 mo (±60 days) and 49/55 (89.1%) patients (95% CI: 77.8, 95.9) achieved successful fusion at 24 mo (+60 days).

Conclusions:
Actifuse Shape is safe and is associated with high rate of bony fusion when implanted as the primary bone graft substitute in spinal fusion surgeries.
Chidamide triggers pyroptosis in T-cell lymphoblastic lymphoma/leukemia via the FOXO1/GSDME axis
Authors: Li Xinlei , Liu Bangdong , Huang Dezhi , Ma Naya , Xia Jing , Zhao Xianlan , Duan Yishuo , Li Fu , Lin Shijia , Tang Shuhan , Li Qiong , Rao Jun , Zhang Xi 
Published: October 2024

Abstract

Background:
T-cell lymphoblastic lymphoma/leukemia (T-LBL/ALL) is an aggressive form of hematological malignancy associated with poor prognosis in adult patients. Histone deacetylases (HDACs) are aberrantly expressed in T-LBL/ALL and are considered potential therapeutic targets. Here, we investigated the antitumor effect of a novel HDAC inhibitor, chidamide, on T-LBL/ALL.

Methods:
HDAC1, HDAC2 and HDAC3 levels in T-LBL/ALL cell lines and patient samples were compared with those in normal controls. Flow cytometry, transmission electron microscopy and lactate dehydrogenase release assays were conducted in Jurkat and MOLT-4 cells to assess apoptosis and pyroptosis. A specific forkhead box O1 (FOXO1) inhibitor was used to rescue pyroptosis and upregulated gasdermin E (GSDME) expression caused by chidamide treatment. The role of the FOXO1 transcription factor was evaluated by dual-luciferase reporter and chromatin immunoprecipitation assays. The efficacy of chidamide in vivo was evaluated in a xenograft mouse.

Results:
The expression of HDAC1, HDAC2 and HDAC3 was significantly upregulated in T-LBL/ALL. Cell viability was obviously inhibited after chidamide treatment. Pyroptosis, characterized by cell swelling, pore formation on the plasma membrane and lactate dehydrogenase leakage, was identified as a new mechanism of chidamide treatment. Chidamide triggered pyroptosis through caspase 3 activation and GSDME transcriptional upregulation. Chromatin immunoprecipitation assays confirmed that chidamide led to the increased transcription of GSDME through a more relaxed chromatin structure at the promoter and the upregulation of FOXO1 expression. Moreover, we identified the therapeutic effect of chidamide in vivo.

Conclusions:
Our study suggested that chidamide exerts an antitumor effect on T-LBL/ALL and promotes a more inflammatory form of cell death via the FOXO1/GSDME axis, which provides a novel choice of targeted therapy for patients with T-LBL/ALL.
Which technique provides more benefits in return to sports and clinical outcomes after anterior cruciate ligament reconstruction: Double-bundle or single-bundle? A randomized controlled study
Authors: Wang Xinjie , Xu Zijie , Song Shitang , Mao Zimu , Huang Ximeng , Luo Michael , Zhou Xiao , Xu Bingbing , Ye Jing , Song Yifan , Yu Jiakuo 
Published: October 2024

Abstract

Background:
The achievement of an optimal return to sport (RTS) has remained a key goal after sports-related injuries, with the ongoing debate on the effectiveness of different surgical approaches for anterior cruciate ligament (ACL) rupture. This study aims to assess clinical outcomes and RTS across various surgical methods, such as anatomical single-bundle reconstruction (ASBR), central-axial single-bundle reconstruction (CASBR), and double-bundle reconstruction (DBR).

Methods:
A randomized clinical trial was conducted, comprising 191 patients who underwent ACL rupture. These patients were divided into three groups based on the ACL reconstruction techniques they received (ASBR, CASBR, DBR). Over the 2-year follow-up period, the study assessed RTS through four single-hop tests, isokinetic extension tests, and limb asymmetry indices. Postoperative graft status was determined using the signal-to-noise quotient (SNQ), while knee function was evaluated using the International Knee Documentation Committee 2000 (IKDC-2000) score, Lysholm score, Tegner score, and degree of knee laxity. A binary logistic regression model was developed to forecast the factors influencing ideal RTS.

Results:
DBR (67.63%) and CASBR (58.00%) exhibited higher RTS passing rates compared to ASBR (30.39%; χ
2 = 19.57, P <0.05). Quadriceps strength symmetry in the lower limbs was identified as the key determinant of RTS (χ
2 = 17.08, P <0.05). The RTS rate was influenced by SNQs of the graft’s tibial site (odds ratio: 0.544) and quadriceps strength of the reconstructed knee joint at 60°/s (odds ratio: 6.346). Notably, the DBR group showed enhanced knee stability, evidenced by superior results in the Lachman test (χ
2 = 13.49, P <0.01), objective IKDC-2000 (χ
2 = 27.02, P = 0.002), and anterior instability test (χ
2 = 9.46, P <0.01). Furthermore, DBR demonstrated superior clinical outcomes based on the Lysholm score (DBR: 89.57 ± 7.72, CASBR: 83.00 ± 12.71, ASBR: 83.21 ± 11.95; F = 10.452, P <0.01) and IKDC-2000 score (DBR: 90.95 ± 7.00, CASBR: 84.64 ± 12.68, ASBR: 83.63 ± 11.41; F = 11.78, P <0.01).

Conclusion:
For patients with ACL rupture, more ideal RTS rate and clinical outcomes were shown in the DBR group than in the ASBR and CASBR groups. Autograft status and quadriceps strength are postively related to RTS.

Trial Registration:

ClinicalTrials.gov (NCT05400460)