bluuebunny/crossref_metadata_2025_split huggingface dataset:
Líderes e Empreendedoras do Pacífico Colombiano: Cultura, Identidade e Associativismo
Authors: Ettinger Valéria Marques Tavares de Menezes 
Published: August 2017

<p class="MsoNormal" style="margin: 4.8pt 0cm; text-align: justify;">Este trabalho é o resultado de uma observação participante realizada na cidade de Guapi na Colômbia, como componente obrigatório da Residência Social1. Inicialmente, o artigo constrói sua premissa teórica a partir da discussão sobre cultura e identidade, fazendo um link com a realidade dos povos do Pacífico colombiano por meio de suas histórias e modo de vida. No segundo momento, o artigo aborda a importância das mulheres afrodescendentes na formação da cultura e das tradições locais, promovendo um encontro com essa realidade a partir da história de vida de uma mulher líder, de uma mulher empreendedora e do processo organizacional de três coletivos de mulheres. Buscou-se, como caminho de construção, a revisão da literatura existente, para contribuir com o embasamento teórico a respeito dos temas cultura, identidade e história das comunidades afrodescendentes na Colômbia. Na obtenção dos dados, foi utilizado o método história de vida por meio de entrevistas com relato de experiência, transcrito em forma de narrativa, mesclado com o olhar do pesquisador. </p>
O Projeto Conexão Local: Uma Avaliação com Base na Política Nacional de Extensão Universitária
Authors: Loebel Eduardo , Gandolfi Peterson Elizandro , Medeiros Cintia Rodrigues Oliveira , Valadão Jr. Valdir Machado 
Published: August 2017

<p style="margin: 0cm 0cm 0pt;">O objetivo deste artigo é avaliar uma experiência do Projeto Conexão Local promovida por uma escola privada de ensino superior em Administração e propor uma reflexão teórica. Os critérios para a avaliação, elaborados a partir dos princípios básicos da Política Nacional de Extensão Universitária, permitem examinar a experiência por meio de duas questões de pesquisa: a experiência pode ser considerada uma genuína ação de extensão universitária conforme os critérios? Quais são os seus principais pontos de melhoria? A pesquisa emprega uma abordagem metodológica qualitativa. Os resultados apontam para quatro lacunas na experiência, discutidas em nível organizacional e institucional. Em decorrência, a experiência objeto de avaliação é considerada uma ação de extensão universitária que atende parcialmente aos critérios. Discute-se que as lacunas não poderão ser superadas sem que haja um debate mais amplo sobre as questões pertinentes aos pressupostos, execução e avaliação da ação de extensão universitária na escola privada de Administração. </p>
Análise da (Re)Configuração Estrutural de uma Organização Conveniada ao Programa Cultura Viva: Estudo de caso a partir da percepção dos gestores
Authors: Almeida Suzanny Carla Santos , Costa Carlos Everaldo Silva da , Araújo Rafaela Albuquerque Valença de , Feitosa Diego Ribeiro 
Published: August 2017

<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%;">Uma das formas de perceber o agrupamento humano em sociedade é a partir das organizações. Sejam públicas, privadas ou da sociedade civil, as mesmas interagem com o ambiente em que atuam e constroem visões de mundo. Neste estudo qualitativo, o objetivo foi perceber de que modo a implementação do Programa Cultura Viva impactou a estrutura de um Ponto de Cultura em Arapiraca, agreste de Alagoas. Para alcançar este objetivo, foi feito um estudo de caso, apoiado pela pesquisa bibliográfica e de campo com observações diretas, além da aplicação de entrevistas semiestruturadas com sujeitos representativos da organização. A associação escolhida é denominada “Cultura para o Desenvolvimento” e foi escolhida intencionalmente e de forma não probabilística. Como considerações sobre o trabalho, observou-se que o convênio com o Governo Federal exige adaptações mútuas e imposição da estrutura governamental no que diz respeito ao uso de mecanismos burocráticos com os quais a organização não era habituada a lidar, o que fez com que o convênio não alcançasse êxito. </p>
Differentiation of Folate‐Receptor‐Positive and ‐Negative Cells Using a Substrate‐Mimicking Fluorescent Probe
Authors: Pal Kaushik , Heinsch Angela , Berkessel Albrecht , Koner Apurba L. 
Published: August 2017

AbstractDiagnosis and therapy exploiting overexpressed receptors on the cell surface is one important strategy in medicine. Determination of the over expression level of a particular receptor is prerequisite for it to be of clinical use. Differentiation between FR‐positive (FR=folate receptor) and ‐negative cells via fluorescence microscopy using a substrate mimetic fluorophore is presented in this work. The strategy adopted here is not the classical FA‐conjugated (FA=folic acid) fluorescent probe but a small and environment‐sensitive pterin‐based (pterin is part of folate, i.e., vitamin B9) fluorescent probe. Electronically diverse pterin‐based fluorescent probes have been designed and synthesized to understand the effect of the binding environment on the receptor–substrate interactions. By utilizing steady‐state UV/Vis and fluorescence along with time‐resolved fluorescence spectroscopy, the effects on the electronic and acid‐base properties of the substrate were investigated. Evidently, one synthesized probe showed FA‐mimicking behavior with strong binding interaction with FR.
Modulation of Starch Digestibility in Breakfast Cereals Consumed by Subjects with Metabolic Risk: Impact on Markers of Oxidative Stress and Inflammation during Fasting and the Postprandial Period
Authors: Lambert‐Porcheron Stéphanie , Normand Sylvie , Blond Emilie , Sothier Monique , Roth Hubert , Meynier Alexandra , Vinoy Sophie , Laville Martine , Nazare Julie‐Anne 
Published: August 2017

AbstractScope: Decreasing postprandial glycaemic excursions may have a beneficial effect on inflammatory and oxidative stress profiles. In this study, we investigated the impact of carbohydrate digestibility modulation per se, as a means of reducing the glycaemic response, on metabolic and inflammatory responses in subjects with metabolic risk factors.Methods and results: Twenty healthy subjects with metabolic risk consumed a cereal product either high in Slowly Digestible Starch (HSDS) or low in SDS (LSDS) at breakfast daily for 3 weeks, in a cross‐over design. Following each 3‐week session, postprandial glycaemia, insulinaemia, the lipid profile, inflammation and oxidative stress markers were assessed and compared to those induced by ingestion of a glucose solution (as a reference). The 2‐h glycaemic and insulinaemic responses were significantly lower following the HSDS breakfast compared with the LSDS breakfast or glucose. No significant differences between the products were observed in terms of the lipid profile, C‐reactive protein, IL‐6 and tumour necrosis factor alpha. We observed a slight increase in fasting lipid peroxidation markers, including an increase in plasma malondialdehyde (MDA) and a decrease in whole blood glutathione (GSH), without significant alteration of urinary F2‐isoprostanes or plasma glutathione peroxidase (GPx) activity.Conclusion: Consumption of HSDS products for 3 weeks significantly altered both postprandial glycaemia and insulinaemia, but was not sufficient to modify the inflammatory profile. Consumption of both cereal products was associated with a slightly higher fasting oxidative stress profile.
Two‐stage designs versus European scaled average designs in bioequivalence studies for highly variable drugs: Which to choose?
Authors: Molins Eduard , Cobo Erik , Ocaña Jordi 
Published: August 2017

The usual approach to determine bioequivalence for highly variable drugs is scaled average bioequivalence, which is based on expanding the limits as a function of the within‐subject variability in the reference formulation. This requires separately estimating this variability and thus using replicated or semireplicated crossover designs. On the other hand, regulations also allow using common 2 × 2 crossover designs based on two‐stage adaptive approaches with sample size reestimation at an interim analysis. The choice between scaled or two‐stage designs is crucial and must be fully described in the protocol. Using Monte Carlo simulations, we show that both methodologies achieve comparable statistical power, though the scaled method usually requires less sample size, but at the expense of each subject being exposed more times to the treatments. With an adequate initial sample size (not too low, eg, 24 subjects), two‐stage methods are a flexible and efficient option to consider: They have enough power (eg, 80%) at the first stage for non‐highly variable drugs, and, if otherwise, they provide the opportunity to step up to a second stage that includes additional subjects.
The persistence and performance of phosphate-solubilizing Gluconacetobacter liquefaciens qzr14 in a cucumber soil
Authors: Wang Jingjing , Wang Huan , Yin Tingting , Xu Song , Zhao Wei , Wang Jin , Huang Zhiyong 
Published: August 2017

Abstract
The persistence and performance of plant growth-promoting microorganisms (PGPMs) in soil are considered critical features for effectiveness, yet they are poorly understood. Here, we investigated the colonization and activity of a new PGPM, phosphate-solubilizing Gluconacetobacter liquefaciens qzr14, in a pot culture experiment using cucumber as test crop for 20 days. The number of G. liquefaciens and bacterial diversity in the rhizosphere and bulk soil were monitored by real-time PCR and DGGE, respectively. Soil phosphorus and cucumber biomass were also examined. G. liquefaciens qzr14 effectively colonized the rhizosphere soil (bacterial density ranging from 2.70 × 108 to 1.18 × 109 copies per gram dry soil). G. liquefaciens qzr14 inoculation had significantly positive effects on bacterial diversity (BD) of the rhizosphere and bulk soil and the ratio of soluble phosphorus to total phosphorus (SP/TP). The number of G. liquefaciens in the rhizosphere soil was significantly related to SP/TP and the BD of the rhizosphere and bulk soil. BD in rhizosphere soil was significantly related to SP/TP and BD in bulk soil. Based on the results of correlation analysis, we inferred that the introduced G. liquefaciens qzr14 effectively colonized the rhizosphere of cucumber, and then expanded its bacterial community by solubilizing soil phosphorus. The expanded bacterial communities might promote cucumber growth by some new functions.
Evaluation of stress effects of copper oxide nanoparticles in Brassica napus L. seedlings
Authors: Nair Prakash M. Gopalakrishnan , Chung Ill Min 
Published: August 2017

Abstract
Rapid growth of nanotechnology has enabled the production and use of engineered nanoparticles (ENPs) in several industries as well as in agriculture areas. This has raised ecotoxicological concerns due to the release of ENPs to the environment. In the present study, we investigated the effects of interactions of copper oxide nanoparticles (CuO NPs) on physiological, biochemical, and molecular indices in seedlings of an important oil seed crop Brassica napus L. The seedlings were treated with 0, 20, 50, 100, 200, 400, and 500 mg/L of CuO NPs for 14 days in half-strength semi-solid Murashige and Skoog medium. The CuO NPs treatment significantly reduced shoot and root growth as well as plant biomass. Shortening and thickening of primary and lateral roots and inhibition of lateral root growth was observed at higher concentrations. An increase in reactive oxygen species generation, and malondialdehyde accumulation was observed. Histochemical staining of roots with propidium iodide and aniline blue indicated cell death and callose formation in roots. Transcriptional modulation of genes related to oxidative stress viz. CuZn superoxide dismutase, catalase, and ascorbate peroxidase was observed. Element content analysis showed an increase in Cu content and decrease in Fe, Mn, and Zn contents. Overall, exposure to CuO NPs caused oxidative injury, cell death, callose formation, and decreased the micro nutrient contents in B. napus seedlings.
The effect of diagnostic criteria on outcome measures in preclinical and prodromal Alzheimer's disease: Implications for trial design
Authors: Bertens Daniela , Tijms Betty M. , Vermunt Lisa , Prins Niels D. , Scheltens Philip , Visser Pieter Jelle ,   Alzheimer's Disease Neuroimaging Initiative
Published: August 2017

AbstractIntroductionWe investigated the influence of different inclusion criteria for preclinical and prodromal Alzheimer's disease (AD) on changes in biomarkers and cognitive markers and on trial sample size estimates.MethodsWe selected 522 cognitively normal subjects and 872 subjects with mild cognitive impairment from the Alzheimer's Disease Neuroimaging Initiative study. Compared inclusion criteria were (1) preclinical or prodromal AD (amyloid marker abnormal); (2) preclinical or prodromal AD stage‐1 (amyloid marker abnormal, injury marker normal); and (3) preclinical or prodromal AD stage‐2 (amyloid and injury markers abnormal). Outcome measures were amyloid, neuronal injury, and cognitive markers.ResultsIn both subjects with preclinical and prodromal AD stage‐2, inclusion criteria resulted in the largest observed decline in brain volumetric measures on magnetic resonance imaging and cognitive markers.DiscussionInclusion criteria influence the observed rate of worsening in outcome measures. This has implications for trial design.
Taylor’s swimming sheet in a yield-stress fluid
Authors: Hewitt D. R. , Balmforth N. J. 
Published: August 2017

A yield stress is added to Taylor’s (Proc. R. Soc. Lond. A, vol. 209, 1951, pp. 447–461) model of a two-dimensional flexible sheet swimming through a viscous fluid. Both transverse waves along the sheet, as in Taylor’s original model, and longitudinal waves are considered as means of locomotion. In each case, numerical solutions are provided over a range of the two key parameters of the problem: the wave amplitude relative to the wavelength and a Bingham number which describes the strength of the yield stress. The numerical solutions are supplemented with discussions of various limits of the problem in which analytical progress is possible. When the yield stress is large, the swimming speed for low wave amplitude is exactly double that for a Newtonian fluid, for either type of wave.
Evidence of paleoecological changes and Mousterian occupations at the Galería de las Estatuas site, Sierra de Atapuerca, northern Iberian plateau, Spain
Authors: Arsuaga Juan Luis , Gómez-Olivencia Asier , Sala Nohemi , Martínez-Pillado Virginia , Pablos Adrián , Bonmatí Alejandro , Pantoja-Pérez Ana , Lira-Garrido Jaime , Alcázar de Velasco Almudena , Ortega Ana Isabel , Cuenca-Bescós Gloria , García Nuria , Aranburu Arantza , Ruiz-Zapata Blanca , José Gil-García María , Rodríguez-Álvarez Xosé Pedro , Ollé Andreu , Mosquera Marina 
Published: August 2017

AbstractHere we present a new site in the Sierra de Atapuerca (Burgos, Spain): Galería de las Estatuas (GE), which provides new information about Mousterian occupations in the Iberian Plateau. The GE was an ancient entrance to the cave system, which is currently closed and sealed by a stalagmitic crust, below which a detritic sedimentary sequence of more than 2 m is found. This has been divided into five litostratigraphic units with a rich assemblage of faunal and lithic remains of clear Mousterian affinity. Radiocarbon dates provide minimum ages and suggest occupations older than 4514C ka BP. The palynological analysis detected a landscape change to increased tree coverage, which suggests that the sequence recorded a warming episode. The macromammal assemblage is composed of both ungulates (mainly red deer and equids) and carnivores. Taphonomic analysis reveals both anthropic, and to a lesser extent, carnivore activities. The GE was occupied by Neanderthals and also sporadically by carnivores. This new site broadens the information available regarding different human occupations at the Sierra de Atapuerca, which emphasizes the importance of this site-complex for understanding human evolution in Western Europe.
The partnership between the Brazilian School Feeding Program and family farming: a way for reducing ultra-processed foods in school meals
Authors: Teo Carla Rosane Paz Arruda 
Published: August 2017

AbstractObjectiveTo evaluate the profile of food acquisition in the National School Feeding Program according to the extent and purpose of food processing in three municipalities of southern Brazil during the implementation period of Law 11.947/2009.DesignDescriptive cross-sectional study. Data for 2008–2010 involved quantities, prices and types of suppliers for food items purchased. In total, 1529 purchases were analysed. The items were classified into the following groups: G1 (unprocessed/minimally processed), G2 (culinary ingredients), G3 (processed), G4 (ultra-processed). Quantities of purchased foods were converted into energy and average prices ($US/4184 kJ (1000 kcal)) were calculated. The proportion of each food group in total purchases was expressed as both a percentage of total energy and a percentage of total expenditure. Data analysis was carried out in Stata version 12.1.SettingThree municipalities in southern Brazil.ResultsRelative contribution to total energy purchased was high for G1 (49·8 %; G2, 23·8 %; G3, 4·5 %; G4, 21·8 %). Among acquisitions from family farming, G1 represented 51·3 % of the total energy purchased; G2, 9·9 %; G3, 19·7 %; G4, 19·0 %. Total cost was as follows: G1, 61·6 %; G2, 3·9 %; G3, 18·5 %; G4, 16·0 %. Prices for food products from family farms were consistently higher. Average price from family farms was 1·3; from conventional suppliers, 0·9.ConclusionsThe implementation of Law 11.947/2009 produced a positive effect on the regional profile of food purchases for the School Feeding Program. However, there is still considerable potential to promote health by strengthening relationships between family farming and school feeding.
ANTONIO VIVALDI AND THE SUBLIME SEASONS: SONORITY AND TEXTURE AS EXPRESSIVE DEVICES IN EARLY EIGHTEENTH-CENTURY ITALIAN MUSIC
Authors: LOCKEY NICHOLAS 
Published: August 2017

ABSTRACTAntonio Vivaldi's cycle of violin concertos dramatizing the four seasons marked a substantial shift in the way that the seasons were depicted in the arts. Moving away from religious and mythological allegory, they exemplify a growing interest in descriptive representation of nature's power and in humanity's complex physical and emotional relationship with elements beyond its control. Positing new connections to Arcadian reform ideals of verisimilitude, this article addresses important questions concerning Vivaldi's pairing of sonnets with concertos and the aesthetic factors behind his choice of narrative topics to depict in the music. The article also demonstrates how Vivaldi used diverse textures and sonorities to create powerful contrasts that heighten the emotional impact of the aural imagery while underlining recurring expressive and pictorial motifs throughout the cycle. These last aspects, in particular, provide a new understanding of the historical significance of Vivaldi'sFour Seasonsas a powerful demonstration of both the expressive potential of the concerto genre and the still underappreciated art of orchestration during the early eighteenth century.
Mergeable nervous systems for robots
Authors: Mathews Nithin , Christensen Anders Lyhne , O’Grady Rehan , Mondada Francesco , Dorigo Marco 
Published: August 2017

AbstractRobots have the potential to display a higher degree of lifetime morphological adaptation than natural organisms. By adopting a modular approach, robots with different capabilities, shapes, and sizes could, in theory, construct and reconfigure themselves as required. However, current modular robots have only been able to display a limited range of hardwired behaviors because they rely solely on distributed control. Here, we present robots whose bodies and control systems can merge to form entirely new robots that retain full sensorimotor control. Our control paradigm enables robots to exhibit properties that go beyond those of any existing machine or of any biological organism: the robots we present can merge to form larger bodies with a single centralized controller, split into separate bodies with independent controllers, and self-heal by removing or replacing malfunctioning body parts. This work takes us closer to robots that can autonomously change their size, form and function.
Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription
Authors: Godbole Amod , Lyga Sandra , Lohse Martin J. , Calebiro Davide 
Published: August 2017

AbstractA new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH receptors traffic retrogradely to the trans-Golgi network (TGN) and activate endogenous Gs-proteins in the retromer-coated compartment that brings them to the TGN. Receptor internalization is associated with a late cAMP/protein kinase A (PKA) response at the Golgi/TGN. Blocking receptor internalization, inhibiting PKA II/interfering with its Golgi/TGN localization, silencing retromer or disrupting Golgi/TGN organization all impair efficient TSH-dependent cAMP response element binding protein (CREB) phosphorylation. These results suggest that retrograde trafficking to the TGN induces local Gs-protein activation and cAMP/PKA signaling at a critical position near the nucleus, which appears required for efficient CREB phosphorylation and gene transcription. This provides a new mechanism to explain the functional consequences of GPCR signaling at intracellular sites and reveals a critical role for the TGN in GPCR signaling.
Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography
Authors: Thunemann Martin , Schörg Barbara F. , Feil Susanne , Lin Yun , Voelkl Jakob , Golla Matthias , Vachaviolos Angelos , Kohlhofer Ursula , Quintanilla-Martinez Leticia , Olbrich Marcus , Ehrlichmann Walter , Reischl Gerald , Griessinger Christoph M. , Langer Harald F. , Gawaz Meinrad , Lang Florian , Schäfers Michael , Kneilling Manfred , Pichler Bernd J. , Feil Robert 
Published: August 2017

AbstractMany pathophysiological processes are associated with proliferation, migration or death of distinct cell populations. Monitoring specific cell types and their progeny in a non-invasive, longitudinal and quantitative manner is still challenging. Here we show a novel cell-tracking system that combines Cre/lox-assisted cell fate mapping with a thymidine kinase (sr39tk) reporter gene for cell detection by positron emission tomography (PET). We generate Rosa26-mT/sr39tk PET reporter mice and induce sr39tk expression in platelets, T lymphocytes or cardiomyocytes. As proof of concept, we demonstrate that our mouse model permits longitudinal PET imaging and quantification of T-cell homing during inflammation and cardiomyocyte viability after myocardial infarction. Moreover, Rosa26-mT/sr39tk mice are useful for whole-body characterization of transgenic Cre mice and to detect previously unknown Cre activity. We anticipate that the Cre-switchable PET reporter mice will be broadly applicable for non-invasive long-term tracking of selected cell populations in vivo.