bluuebunny/crossref_metadata_2025_split huggingface dataset:
Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits
Authors: Zhan Xiang , Zhao Ni , Plantinga Anna , Thornton Timothy A , Conneely Karen N , Epstein Michael P , Wu Michael C 
Published: June 2017

AbstractGenetic association studies often collect a wide range of complex traits, including high-dimensional and structured omics measurements. The complex...Many genetic association studies collect a wide range of complex traits. As these traits may be correlated and share a common genetic mechanism, joint analysis can be statistically more powerful and biologically more meaningful. However, most existing tests for multiple traits cannot be used for high-dimensional and possibly structured traits, such as network-structured transcriptomic pathway expressions. To overcome potential limitations, in this article we propose the dual kernel-based association test (DKAT) for testing the association between multiple traits and multiple genetic variants, both common and rare. In DKAT, two individual kernels are used to describe the phenotypic and genotypic similarity, respectively, between pairwise subjects. Using kernels allows for capturing structure while accommodating dimensionality. Then, the association between traits and genetic variants is summarized by a coefficient which measures the association between two kernel matrices. Finally, DKAT evaluates the hypothesis of nonassociation with an analytical P-value calculation without any computationally expensive resampling procedures. By collapsing information in both traits and genetic variants using kernels, the proposed DKAT is shown to have a correct type-I error rate and higher power than other existing methods in both simulation studies and application to a study of genetic regulation of pathway gene expressions.
Analysis of treatment results of endophthalmitis patients accordingto the data from the City Ophthalmology Center for 2014-2015
Authors: Astakhov Sergey Yu. , Shchukin Andrey D. 
Published: June 2017

Aim. To estimate development terms, visual functions upon hospital admission and discharge, and medical and surgical treatment results of different types of endophthalmitis.
Materials and methods. Data of 40 patients who received treatment for postoperative, endogenous, and posttraumatic endophthalmitis were studied. The mean age of patients was 61 years.
Results and discussion. Patients with postoperative endophthalmitis have higher baseline visual acuity, and emergency vitrectomy is a method of choice. Patients with endogenous severe endophthalmitis need enucleation more often. Intravitreal antibiotic injection does not always cause an improvement in endophthalmitis, but could be used as an adjunct to systemic therapy or as a measure in anticipation of vitrectomy.
Antibiotic susceptibility pattern of bacteria isolated from patients of respiratory tract infection in a tertiary care hospital of Central India
Authors: Dhakre Shilpi , Reddy Pooja , Kulmi Mohit , Goyal Chhaya 
Published: June 2017

Background: Respiratory tract infections are one of the commonest types of infections affecting the Indian population and are a significant cause of morbidity and mortality. To deal with multidrug resistance one should be armed with region specific data about the susceptibility patterns of antimicrobials. This study was planned to identify the common pathogens responsible for the respiratory tract infection and their antibiotic susceptibility patterns.Methods: Smears were prepared from the specimens and gram stains of all clinical samples were done. The organisms were grown on various media and identified according to the standard procedures. The susceptibility patterns of the bacterial pathogens were determined following the panel of antimicrobial agents. Descriptive statistics were used for data analysis.Results: Out of 513 samples 471 samples were further processed. Klebsiella (30.42%) was found to be commonest pathogen followed by Pseudomonas (28.36%). Ampicillin and piperacillin /tazobactam combination were found to be highly efficient against Pseudomonas (83% and 58.8% respectively), E. coli (68% and 50.7% respectively), and Klebsiella (43% and 30.3% respectively). Conclusions: In our study, we found penicillins as the most efficacious antimicrobials to treat respiratory pathogens. The study reveals that the antibiotic susceptibility pattern varies across regions. The prescription of a right antibiotic, for a right patient will help to minimize the menace of emergence of antimicrobial resistance.
A demographic study on type of accidents, injuries and associated factors, patients attending emergency trauma care at tertiary care teaching hospital
Authors: Prasad Raja Vikram , Nandanwar C. Y. , Isaac Ebenezer B. S. 
Published: June 2017

Background: Road traffic accidents (RTA) is considered to be among top five cause of concern in with morbidity and mortality with socioeconomic repercussions among developing countries. RTA’s are manmade disaster which involves human suffering and socioeconomic costs in terms of premature deaths, injuries, etc. The objective of study was to know the prevalence of various types of accidents, injuries and associated factors.Methods: This study is prospective observational study, was conducted at Tertiary Care Teaching Hospital, SRMC, A.P. Enrollment of patients were registered in emergency trauma care, included all types of accidents and injuries. Patients were interviewed with the pre-tested proforma. After written informed consent, victims were interviewed and attendants were interviewed where patients were unable to answer which is part of Inclusion criteria in the study. Injuries recorded were graded according to Trauma Index. Other required information was collected from medicolegal records from hospital medical records department.Results: Total of 153 cases recorded at emergency Trauma care unit, of which males are 135 (88.235%) and females 18 (11.764%). The highest percentage was falling between 20-29 years followed by 30-39, 40-49 years.3,4 According to trauma index injuries, Minor were 108 (70.588%) and Major were 45 (20.411%). Of all injuries RTA’s were 111 (72.549%), recorded as the major portion.2 The injuries were more due to Bikes 51 (45.945%), followed by pedestrians 30 (27.027%) as victims, which took place in the evening and late nights were 93 (60.784%), followed by early mornings were 42 (27.450%).Conclusions:Conclusions of study showed that males were involved more than females in RTA’s falling between 20-49 years. Most of the injuries recorded were minor followed by major injuries from Road Traffic Accidents, which occurred during evenings and late nights. Type of vehicles involved in RTA’s was two wheelers followed by pedestrians and people who travelled in share Autos.
Comparative study of functional outcome of dynamic compression plating with intramedullary interlocking nailing in close fracture shaft of humerus in adults
Authors: Rabari Yash B. , Prasad D. V. , Somanni Ashish M. , Kumar Pushpak 
Published: June 2017

<p class="abstract"><strong>Background:</strong> Humeral shaft includes 1% of all fractures. The advantage of operative management is early mobilization and patients comfort. Most of the studies compare two main modalities of management, 1. dynamic compression plate 2. intramedulary interlocking nail, with respect to fracture union as major criteria. Very few studies have compared functional outcome with respect to shoulder and elbow joint. The purpose of this study is to compare the outcomes of each method of fixation. (Dynamic compression plating and interlocking nailing) for the fracture shaft of humerus and to analyse statistically significant difference in the results of these two methods.</p><p class="abstract"><strong>Methods:</strong> There were 58 patients of fracture shaft humerus were enrolled during 2 May 2015 to 2 January 2017 in the study. They were randomly divided into two groups, DCP group and IMILN group, each having 29 patients and compare the functional outcome of both groups with each other.<strong></strong></p><p class="abstract"><strong>Results:</strong> There were total 53 patients among them 26 (49.05%) treated with DCP and 27 (55.95%) treated with intramedullary interlocking nail (IMILN).The mean age of patient treated with DCP was 40.12 years (SD±8.51, Min-Max: 25-60) and treated with IMILN was 41.96 years (SD±11.04, Min-Max: 22-61). Road traffic accident was major mode of injury to shaft of humerus.</p><strong>Conclusions:</strong>Dynamic compression plating is preferable technique than interlocking nailing for fracture shaft of humerus in adults.<p> </p>
Comparing functional outcome in lateral end clavicle fracture after conservative and plating
Authors: Kale Sachin Y. , Chaudhari Prasad , Singh Shikhar D. , Dhar Sanjay B. , Samant Prakash D. , Tayade Abhijit 
Published: June 2017

<p class="abstract"><strong>Background:</strong> Fractures of the clavicle have been traditionally treated non- operatively but has been associated with various postoperative complications. In this study, we analyzed the outcomes of the operative management and compare its results with conservative treatment considering it as standard treatment option.</p><p class="abstract"><strong>Methods:</strong> The present study was carried out at the Department of Orthopedics, DY Patil Medical College and Hospital, Navi Mumbai. Open fractures, fractures associated with complication like head injury with associated other bone injuries were included in this study. We excluded patients less than 18 years of age, patients with middle third fracture of clavicle and patients with medial end clavicle fracture. The fractures were classified according to Robinson’s classification. Patients were followed up every week for 4 weeks then at 8 weeks, 12 weeks, 6 months and 1 year. The functional outcomes were assessed by Constant and Murley score.<strong></strong></p><p class="abstract"><strong>Results:</strong> We included 48 patients in the study, 34 of which were males, average age of the patients was 37.53±7.64 years. 23 injuries were on the left. There was statistically significant better union times with operative management (p=0.034). Various complications were observed like infection, implant failure, man union, non-union, deformity and skin infections, statistically seen more in patients who underwent conservative management. Overall, patients experienced excellent and good results with operative management in 6 and 12 patients respectively.</p><strong>Conclusions:</strong>Operative treatment gave statistically significant functional outcome and early healing compared to conservatively treated in displaced, communited lateral end clavicle fractures. <p> </p>
Viability and Osteogenic Differentiation of Human Periodontal Ligament Progenitor Cells Are Maintained After Incubation With Porphyromonas gingivalis Protein Extract
Authors: Albiero Mayra Laino , Stipp Rafael Nóbrega , Saito Miki Taketomi , Casati Márcio Zaffalon , Sallum Enilson Antonio , Nociti Francisco Humberto , Silvério Karina Gonzales 
Published: June 2017

Background: Porphyromonas gingivalis (Pg) is a major periodontal pathogen that contains immunostimulatory components. Periodontal ligament mesenchymal stem cells (PDLMSCs) are responsible for regeneration of the periodontium that is lost due to periodontitis. Pathologic factors within the microenvironment that impair resident PDLMSCs are not well understood. The present study investigates in vitro the effects of Pg protein extract (PgPE) on biologic properties of CD105‐enriched PDL progenitor cell populations (PDL‐CD105+).Methods: Five populations of PDL‐CD105+ cells were exposed to PgPE and assessed for cell viability, apoptosis, and proinflammatory gene expression (interleukin‐1β [IL‐1β], tumor necrosis factor‐alpha [TNF‐α], and IL‐6) by quantitative reverse transcription polymerase chain reaction, IL‐6 immunostaining, activation of IL‐6/signal transducer and activator of transcription (STAT) 3 signaling pathway, and osteogenic differentiation potential.Results: PgPE treatment (2 μg/mL) did not affect cell viability or survival but induced a significant increase in IL‐1β, TNF‐α, and IL‐6 messenger RNA (mRNA) expression and positive staining for IL‐6. A total of 29 genes from the IL‐6/STAT3 pathway were upregulated on PgPE stimulation. These genes are related to biologic processes involved in the control of cell survival (B‐cell lymphoma 2 [BCL2]), cell proliferation (hepatocytehepatocyte growth factor), cytokine‐mediated signaling pathway (suppressor of cytokine signaling 3, C–X–C ligand 8 [CXCL8]), and response to stress (CXCL8, mitogen‐activated protein kinase 3, BCL2‐associated X protein, and BCL2). Additionally, PgPE treatment caused an increase in alkaline phosphatase mRNA expression in PDL‐CD105+ cells after 7 days of osteogenic induction, although mineral nodule formation was comparable to the control group.Conclusions: These results suggest that the inflammatory profile induced by PgPE treatment in PDL‐CD105+ cells did not affect cell viability, apoptosis, or osteogenic differentiation, perhaps due to increased expression of genes involved in the control of cell proliferation and protection against cell death.
Iriarte, Ana y Luísa de Nazaré Ferreira (coords.), Idades e género na literatura e na arte da Grécia antiga, Coimbra, Imprensa da Universidade de Coimbra-Annablume, 2015, 215 págs.
Authors: González Delgado Ramíro 
Published: June 2017

La colección Humanitas Supplementum, de la conocida revista conimbricense,presenta bajo el número 34 un interesante y documentado estudio monográfico colectivo que analiza las ideas sociales que sobre edad y género se perciben en la Grecia antigua a través de diferentes fuentes literarias, iconográficas y epigráficas. Son en total siete contribuciones de investigadores de tres países: tres españolas, dos argentinas y dos portugueses (nacionalidad del único autor). En conjunto, estamos ante un análisis que, dejando a un lado al varón griego adulto, atiende al resto de edades y sexos (niños, doncellas, ancianos y prostitutos).
Eurídice y el naciente poder femenino en Macedonia
Authors: Sánchez Barragán E. Gabriel 
Published: June 2017

La historia de la reina Eurídice de Macedonia da inicio a lo que, con los años, se convertirá en una constelación de soberanas helenísticas que disputarán el trono a sus maridos e hijos y que concluye con la famosa Cleopatra VII. El presente artículo comienza por señalar algunos puntos de importancia para la comprensión del poder femenino antiguo: por principio revisa los procesos ideológicos que conllevaron a la construcción social del patriarcado, para luego analizar brevemente el papel de las mujeres en Macedonia y de las reinas en particular con las personas de las primeras princesas y su posible vínculo con la religión y, merced a ésta, con el poder. Se procede al estudio de la personalidad de Eurídice, madre de Filipo II, desde las teorías con respecto a su origen ilirio, su matrimonio con Amintas y la necesidad que de aquél pudo tener el rey, para concluir con su papel en la conjura de Ptolomeo de Aloro y su rostro como madre y soberana que inaugura el interés de las mujeres por el poder en Macedonia.
Effect of Work Attitude and Total Productive Maintenance on the Overall Equipment Effectiveness and Production Continuity
Authors: Haming Puadi , Nurnajamuddin Mahfud , Hafied Hamzah , Serang Serlin 
Published: June 2017

<div><p><em>This study aims to examine and analyze the impact of work attitude, Total Productive Maintenance (TPM) on the Overall Equipment Effectiveness (OEE) and production continuity and the other effect of Work Attitude and Total Productive Maintenance (TPM) on production continuity: The mediating role of Overall Equipment Effectiveness (OEE). The research was conducted at PT. Semen Tonasa i.e. units II to V unit which is the largest cement producer in eastern Indonesia. Withdrawal of respondents did with the criteria that only respondents yang having their respective sectors and who have work experience of at least one year were used as samples. Results of analysis Partial Least Square (PLS) Version 2.0.M3 used in analyzing the contribution of exogenous variables on endogenous variables directly, Sobel Test was used for pushing analyze the contribution of the indirect effect (mediation) whereas importance- performance analysis (IPA) to analogous interpret the relationship loading factor value and the average value. The results of this study provide evidence of work attitude has a positive and significant effect on the overall equipment effectiveness (OEE), total productive maintenance (TPM) has a positive and significant effect on overall equipment effectiveness (OEE), work attitude, total productive maintenance (TPM) and overall equipment effectiveness (OEE) positive and significant impact on production continuity.</em></p></div>
Heineken's Acquisition of Asia Pacific Breweries: Accounting for Business Combinations and Changes in Ownership Interests
Authors: Tan Pearl , Lim Chu-Yeong 
Published: June 2017

ABSTRACT
On July 20, 2012, Heineken, a Dutch brewery offered S$5.125 billion (Singapore dollars; approximately US$4.1 billion) to buy Asia Pacific Breweries Ltd (APB; formerly, Malayan Breweries Limited) from its Singapore-based joint venture partner, Fraser and Neave, Limited. (F&N). At that point, Heineken and F&N had joint control over APB through the joint venture vehicle Asia Pacific Investments Pte Ltd (APIPL). Brewery business under the joint arrangement had moved on quite predictably from the time APB was formed in 1931. However, the calm changed to high drama when Thai Beverage, owned by one of Thailand's tycoons, made a bid for F&N and APB. Heineken was quick to respond by aggressively buying shares of APB, leading to a large control premium being paid in the final offer price. The bidding war was largely motivated by the Dutch and Thai beer giants, each wanting to own the iconic Tiger beer brand that was owned by APB and thus take control of APB's strong market share in the fast-growing market of Asia. The Heineken bid for APB presents an interesting case study regarding the motivations for acquisitions, the nature of control, and accounting for acquisitions. The case also presents rich issues in accounting for changes in ownership interests with and without gain of control.
The Role of K+ And Ca2+ Ion Channels in Α-Terpinyle Acetate-Induced Vasodilation in Rat’s Aortic Rings
Authors: Kheder Dlzar A. , Al-Habib Omar A. M. , Adam Lina N. 
Published: June 2017

The monoterpene, α-terpinyle acetate (TA) is a constituent of essential oils present in aromatic plants. Since the role of ion channels and endothelial hyperpolarizing factors in TA induced relaxation in rat’s aorta is unknown, the current study aimed to study the mechanism underlying the vasodilatory effect of TA in isolated aortic rings. Terpinyle acetate induced a potent vasodilation in rat aortic rings with a percentage of relaxation of 63.79 %. The results of the role of K+ channel subtypes in vasorelaxation revealed that both Kv and KATP played a major role since GLIB produced a maximum percent of inhibition in the relaxation produced by TA to 8.91 %; this was followed by 4-AP in which the percent of inhibition reduced to 14.95. On the other hand, Kir played no role in the TA induced vasorelaxation since BaCl2 did not produce any inhibition in aortic relaxation. Furthermore, also L-type Ca2+ channel played no role in TA induced relaxation since the L-type Ca2+ channel inhibitor Nifedipine did not reduce the percent of relaxation. Endothelium also played a considerable role in the induced vasorelaxation since, in denuded aorta, the percent of relaxation was reduced to 36%. Preincubation of the aortic ring with methylene blue, a soluble cGMP inhibitor also significantly reduced the TA induced relaxation to 16.39%. In contrast, preincubation with cyclooxygenase inhibitor Indomethacin did not produce any inhibitory effect on AT induced vasorelaxation. It can be concluded from these novel results that AT induced vasorelaxation involve the activation of KV, KATP channels and at least partly dependent on endothelium via the activation NO-cGMP signal transduction pathway.
Phosphorus addition mitigates N2O and CH4 emissions in N-saturated subtropical forest, SW China
Authors: Yu Longfei , Wang Yihao , Zhang Xiaoshan , Dörsch Peter , Mulder Jan 
Published: June 2017

Abstract. Chronically elevated nitrogen (N) deposition has led to severe nutrient imbalance in forest soils. Particularly in tropical and subtropical forest ecosystems, increasing N loading has aggravated phosphorus (P) limitation of biomass production, and has resulted in elevated emissions of nitrous oxide (N2O) and reduced uptake of methane (CH4), both of which are important greenhouse gases. Yet, the interactions of N and P and their effects on greenhouse gas emissions remain elusive. Here, we report N2O and CH4 emissions together with soil N and P data for a period of 18 months following a single P addition (79 kg P ha−1, as NaH2PO4 powder) to an N-saturated, Masson pine-dominated forest soil at TieShanPing (TSP), Chongqing, south-western (SW) China. We observed a significant decline in both nitrate (NO3−) concentrations in soil water (5 and 20 cm depths) and in soil N2O emissions, following P application. We hypothesise that enhanced N uptake by plants in response to P addition, resulted in less available NO3− for denitrification. By contrast to most other forest ecosystems, TSP is a net source of CH4. P addition significantly decreased CH4 emissions and turned the soil from a net source into a net sink. Based on our observation and previous studies in South America and China, we believe that P addition relieves N inhibition of CH4 oxidation. Within the 1.5 years after P addition, no significant increase of forest growth was observed and P stimulation of forest N uptake by understorey vegetation remains to be confirmed. Our study indicates that P fertilisation of N-saturated, subtropical forest soils may mitigate N2O and CH4 emissions, in addition to alleviating nutrient imbalances and reducing losses of N through NO3− leaching.
Postmodernism—Posthumanism—Evolutionary Anthropology
Authors: Welsch Wolfgang 
Published: June 2017

ABSTRACT
The article explores the relationship between postmodernism, posthumanism, and evolutionary anthropology. In contrast to standard postmodernism, which provides just an updating of modernity, evolutionary anthropology (as here conceived) transcends the basic axiom of modernity, that of an unbreachable gap between man and world. It shows that humans are inherently worldly beings, deeply rooted in the process of evolution, and therefore participants in the process of life that share a great many traits with other living beings. Posthumanism, too, tries to establish a new framework for conceptualizing the human, one that equally leaves behind the modern assumption of human uniqueness and supremacy. Yet this is often done in a more declaratory than evidence-based manner. Turning to the scientific arguments of evolutionary anthropology might help posthumanism to become more solid. In an evolutionary perspective, two further main points of posthumanism—the fusion of human and artificial intelligence and human enhancement—appear quite natural. In cosmic and biotic evolution, matter and mind were never totally distinct, but coevolved, and enhancement was constitutive to human evolution from its beginning some million years ago. Evolutionary anthropology has a lot to offer to posthumanism.