bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing oxygen permeation via multiple types of oxygen transport paths in hepta‐bore perovskite hollow fibers
Authors: Zhu Jiawei , Wang Tianlei , Song Zhe , Liu Zhengkun , Zhang Guangru , Jin Wanqin 
Published: June 2017

SignificanceThe multiple types of efficient oxygen transport paths were demonstrated in high‐mechanical‐strength hepta‐bore Ba0.5Sr0.5Co0.8Fe0.2O3‐δ hollow fiber membranes. These types of paths play a prominent role in enhancing oxygen permeation fluxes (17.6 mL min−1 cm−2 at 1223 K) which greatly transcend the performance of state‐of‐the‐art Ba0.5Sr0.5Co0.8Fe0.2O3‐δ hollow fiber membranes, showing a good commercialization prospect. © 2017 American Institute of Chemical Engineers AIChE J, 63: 4273–4277, 2017
The in vitro mucolytic effect of xylitol and dornase alfa on chronic rhinosinusitis mucus
Authors: Hardcastle Tim , Jain Ravi , Radcliff Fiona , Waldvogel‐Thurlow Sharon , Zoing Melissa , Biswas Kristi , Douglas Richard 
Published: June 2017

BackgroundThe overproduction and stagnation of purulent mucus impair mucociliary clearance and exacerbate the symptoms of chronic rhinosinusitis (CRS). There is a clinical need for effective topical mucolytic agents to facilitate removal of mucus and improve postoperative outcomes.MethodsThe effects of xylitol (5%) and dornase alfa (1 mg/mL) on mucus and mucus crusts were investigated. Viscoelasticity and viscosity of wet mucus derived from 30 CRS patients was measured with a plate rheometer. Postoperative dried mucus crust dissolution was measured by examining peripheral transparency, central transparency, and border definition of treated crust samples from 17 CRS patients.ResultsXylitol and dornase alfa reduced wet mucus viscoelasticity at a frequency of 0.1 Hz significantly more than the saline control. Treatments also produced significantly lower viscosities than saline at a shear rate of 10 and 100 seconds−1. Xylitol and dornase alfa significantly decreased mucus crust border definition relative to saline.ConclusionXylitol and dornase alfa may be efficacious mucolytics, encouraging the breakdown of postoperative mucus crusts and the reduction of viscoelasticity and viscosity of wet mucus. In vivo study is required to evaluate the potential of these agents in treating recalcitrant CRS.
Associations of endocrine stress‐related gene polymorphisms with risk of autism spectrum disorders: Evidence from an integrated meta‐analysis
Authors: Yang Ping‐yuan , Menga Ya‐jing , Li Tao , Huang Yi 
Published: June 2017

Autism spectrum disorders (ASD) are related to serotonin transporter (5‐HTT) and catechol‐O‐methyl transferase (COMT) as two most monoaminergic polymorphic variations. However, multiple studies assessing rs4680 and 5‐HTTLPR variants in ASD have reported inconsistent results. Therefore, we conducted an integrated meta‐analysis to combine case‐control and transmission/disequilibrium test (TDT) studies to determine whether COMT and 5‐HTT are associated with ASD. We searched multiple electronic databases (PubMed, EmBase and Web of Science) to identify studies assessing the rs4680 and 5‐HTTLPR variants in ASD from Jan 1997 to Dec 2016. Then allelic data from case–control and TDT studies were analyzed by the Catmap package in the R software. A total of 5 studies were eligible for the meta‐analysis of rs4680, including 3 case–control, 1 TDT and 1 TDT & case–control studies. Meanwhile, 22 studies of 5‐HTTLPR were available, including 16 TDT, 4 case–control and 2 TDT & case–control studies. The current meta‐analysis included 814 ASD cases, 741 controls and 311 families related to rs4680; 749 ASD cases, 1,118 controls and 1,861 families relevant to 5‐HTTLPR were also evaluated. For rs4680, the pooled OR was 1.18 (95% CI = 0.87–1.59, P = 0.29, Pheterogeneity < 0.00001). There was no significant association of rs4680 with risk of ASD between the two subgroups. For 5‐HTTLPR, the pooled OR was 1.05 (95% CI = 0.92–1.20, P = 0.4652, Pheterogeneity < 0.00001). Meanwhile, we found no significant risk in individual case–control or TDT studies. The above findings indicated that neither COMT rs4680 nor 5‐HTT 5‐HTTLPR polymorphism significantly affects ASD risk. Autism Res 2017, 10: 1722–1736. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryOur results showed no evidence of significant association of either COMT rs4680 or 5‐HTT 5‐HTTLPR variants with ASD, showing that these two genes may not be major susceptible genetic factors in ASD occurrence, and may have a reciprocal action with each other in combination with environmental factors. These findings further provide evidence that a single gene variant may not dictate autism occurrence, but possibly contributes to a specific phenotype or subtype of ASD.
Neoadjuvant chemotherapy with MRI monitoring for breast cancer
Authors: Dave R V , Millican-Slater R , Dodwell D , Horgan K , Sharma N 
Published: June 2017

Abstract

Background
Neoadjuvant chemotherapy (NACT) is increasingly being offered to patients with breast cancer. No survival benefit has been demonstrated for NACT, but it may serve to reduce tumour size and improve prognosis through the attainment of a pathological complete response (pCR). The role and mode of MRI monitoring during NACT remain unclear.

Methods
Patients managed with NACT at a UK centre over 7 years were studied using a prospectively maintained database, which also included details of MRI. Clinicopathological and radiological predictors of NACT response were analysed in a univariable setting and survival analysis was undertaken using the Kaplan–Meier method.

Results
A total of 278 patients underwent surgery following NACT, of whom 200 (71·9 per cent) had residual invasive disease and 78 (28·1 per cent) achieved a pCR. Attaining a pCR improved survival significantly compared with that of patients with residual invasive disease (mean 77·1 versus 66·0 months; P = 0·004) and resulted in significantly fewer recurrences (6·0 versus 24·3 per cent; P = 0·001). The pCR rate varied significantly among molecular subgroups of breast cancer (P &lt; 0·001): luminal A, 6 per cent; luminal B/human epidermal growth factor 2 receptor (Her2)-negative, 21 per cent; luminal B/Her2-positive, 35 per cent, Her2-positive/non-luminal, 72 per cent; and triple-negative breast cancer (TNBC), 32 per cent. High-grade disease (G3) correlated with an increased rate of pCR. A radiological response seen on the mid-treatment MRI was predictive of pCR (sensitivity 77·6 per cent, but specificity only 53·3 per cent), as was complete radiological response at final MRI (specificity 97·6 per cent, but sensitivity only 32·2 per cent).

Conclusion
NACT allows identification of patient subgroups within TNBC and Her2-positive cohorts with a good prognosis. MRI can be used to identify patients who are responding to treatment.
Effect of the Leaf Essential Oil from Cinnamosma madagascariensis Danguy on Pentylenetetrazol‐induced Seizure in Rats
Authors: Rakotosaona Rianasoambolanoro , Randrianarivo Emmanuel , Rasoanaivo Philippe , Nicoletti Marcello , Benelli Giovanni , Maggi Filippo 
Published: June 2017

In the Malagasy traditional practices, the smoke from burning leaves of Cinnamosma madagascariensis Danguy is inhaled to treat brain disorders such as dementia, epilepsy, and headache. In the present work, we have evaluated the in vivo anticonvulsant effects of the essential oil from leaves of C. madagascariensis (CMEO). CMEO was isolated by steam distillation. The anticonvulsant activity of CMEO (0.4 and 0.8 ml/kg bw) administered subcutaneously was evaluated on pentylenetetrazol (PTZ)‐induced seizures in Wistar rats; diazepam was used as positive control. Linalool, limonene, and myrcene were the major CMEO constituents. At the dose of 0.8 ml/kg, CMEO completely arrested the PTZ‐induced convulsions with moderate sedative effects. The traditional anticonvulsant use of C. madagascariensis was confirmed allowing us to candidate molecules from CMEO as potential drugs to treat convulsions associated with strong agitation.
Proton in a Confined Space: Structural Studies of H+⊂Crypt‐111 Iodide and Some Halogen‐Bonded Derivatives
Authors: Kumar Vijith , Pilati Tullio , Quici Silvio , Chierotti Michele R. , Nervi Carlo , Gobetto Roberto , Resnati Giuseppe 
Published: June 2017

AbstractExperimental observations and modeling data are reported on the solid‐state structural features of crypt‐ 111⋅HI (1) and the three‐component co‐crystals that 1 forms with α,ω‐diiodoperfluoroalkanes 2 a–d. X‐ray analyses indicate that, in all five systems and at low temperature, the caged proton is covalently bonded to a single nitrogen atom and is involved in a network of intramolecular hydrogen bonds. In contrast, room‐temperature, solid‐state 15N NMR spectroscopy suggests magnetic equivalency of the two N atoms of crypt‐111 in both 1 and co‐crystals of 1 with diiodoperfluoroalkanes. Computational modelling confirms that the acidic hydrogen inside the cavity preferentially sits along the internitrogen axis and is covalently bonded to one nitrogen. The computed energy barriers suggest that the hopping of the encapsulated proton between the two N atoms of the cage can occur in the halogen‐bonded co‐crystals of 1⋅2, but it is hardly possible in the pure H+⊂crypt‐111 iodide 1. These different pictures of the proton position and dynamics obtained by using different techniques and conditions confirm the unique characteristics of the confined space within the cavity of crypr‐111 and the distinctive features of processes occurring therein.
From Well‐Defined Alkylzinc Phosphinates to Quantum‐Sized ZnO Nanocrystals
Authors: Wolska‐Pietkiewicz Małgorzata , Grala Agnieszka , Justyniak Iwona , Hryciuk Dymitr , Jędrzejewska Maria , Grzonka Justyna , Kurzydłowski Krzysztof J. , Lewiński Janusz 
Published: June 2017

AbstractDespite various applications of alkylzinc carboxylates in chemistry and materials science, the corresponding organozinc derivatives of organophosphorus compounds still represent an insufficiently explored area. To fill this gap, we report on the synthesis of alkylzinc phosphinates and their use as efficient precursors of phosphinate‐coated ZnO nanocrystals in the quantum size regime. Examples of a series of alkylzinc phosphinates with the general formula [RZn(O2PR′2)] (R=tBu or Et) have been prepared through equimolar reactions between ZnR2 and a selected phosphinic acid, namely dimethylphosphinic acid (dmpha‐H), methylphenylphosphinic acid (mppha‐H), diphenylphosphinic acid (dppha‐H), or bis(4‐methoxyphenyl)phosphinic acid (dmppha‐H). The reactivities of alkylzinc phosphinate complexes toward H2O and O2 have also been investigated, which resulted in the isolation of two oxo‐zinc phosphinate clusters, that is, [Zn4(μ4‐O)(dppha)6] and [Zn4(μ4‐O)(dmppha)6], as well as the unique alkoxy(oxo)zinc cluster [Zn4(μ4‐O)(μ2‐OtBu)(dppha)5]. Analysis of the crystal structures has revealed that organozinc complexes incorporating phosphinate ligands exhibit a unique capacity for shape‐driven self‐assembly to produce extended networks, including noncovalent quasi‐porous materials. Finally, monodispersed and quantum‐sized ZnO NCs coated with phosphinate ligands have been prepared using a non‐external‐surfactant‐assisted wet‐chemical organometallic approach based on well‐defined [RZn(O2PR′2)]‐type compounds. The resulting brightly luminescent ZnO NCs exhibit average core sizes and hydrodynamic diameters in the ranges 2–4.5 nm and 5–8 nm, respectively. The size of the inorganic core is slightly affected by the character of the incorporated phosphinate ligand, being smallest for ZnO NCs coated by asymmetrically substituted mppha ligands. Regardless of whether or not various phosphinate coating ligands could be controllably applied on the ZnO NC surface, no significant differences were found in the luminescence profiles of the analyzed nanosystems.
Excess Electron Transfer through DNA Duplexes Comprising a Metal‐Mediated Base Pair
Authors: Hensel Susanne , Eckey Kevin , Scharf Philipp , Megger Nicole , Karst Uwe , Müller Jens 
Published: June 2017

AbstractExcess electron transfer through one set of DNA duplexes comprising either one or two metal‐mediated thymine–HgII–thymine base pairs was studied. Towards this end, the metal‐mediated base pair(s) were introduced between an artificial nucleoside bearing a N,N,N′,N′‐tetramethyl‐1,5‐diaminonaphthalene derivative (dN, acting as a photoinducible electron donor) and 5‐bromo‐2′‐deoxyuridine (dB, acting as an electron acceptor). Upon one‐electron reduction, dB loses a bromide ion. The amount of unreacted dB remaining after irradiation—determined by LC/ICP‐MS—was used to evaluate the charge‐transfer efficiency across the metal‐mediated base pair(s). Reference measurements with canonical adenine:thymine base pairs prove the applicability of this approach for the detection of charge transfer in DNA. The data indicate that, for the set of DNA duplexes under investigation, excess electron transfer across a thymine–HgII–thymine base pair proceeds with low efficiency, comparable to the transfer across a thymine:thymine mispair. Two contiguous thymine–HgII–thymine base pairs effectively shut down excess electron transfer.
Selectivity of C−H versus C−F Bond Oxygenation by Homo‐ and Heterometallic Fe4, Fe3Mn, and Mn4 Clusters
Authors: de Ruiter Graham , Carsch Kurtis M. , Takase Michael K. , Agapie Theodor 
Published: June 2017

AbstractA series of tetranuclear [LM3(HFArPz)3OM′][OTf]2 (M, M′=Fe or Mn) clusters that displays 3‐(2‐fluorophenyl)pyrazolate (HFArPz) as bridging ligand is reported. With these complexes, manganese was demonstrated to facilitate C(sp2)−F bond oxygenation via a putative terminal metal‐oxo species. Moreover, the presence of both ortho C(sp2)−H and C(sp2)−F bonds in proximity of the apical metal center provided an opportunity to investigate the selectivity of intramolecular C(sp2)−X bond oxygenation (X=H or F) in these isostructural compounds. With iron as the apical metal center, (M′=Fe) C(sp2)−F bond oxygenation occur almost exclusively, whereas with manganese (M′=Mn), the opposite reactivity is preferred.
Germline genetic variants in men with prostate cancer and one or more additional cancers
Authors: Pilié Patrick G. , Johnson Anna M. , Hanson Kristen L. , Dayno Megan E. , Kapron Ashley L. , Stoffel Elena M. , Cooney Kathleen A. 
Published: June 2017

BACKGROUNDProstate cancer has a significant heritable component, and rare deleterious germline variants in certain genes can increase the risk of the disease. The aim of the current study was to describe the prevalence of pathogenic germline variants in cancer‐predisposing genes in men with prostate cancer and at least 1 additional primary cancer.METHODSUsing a multigene panel, the authors sequenced germline DNA from 102 men with prostate cancer and at least 1 additional primary cancer who also met ≥1 of the following criteria: 1) age ≤55 years at the time of diagnosis of the first malignancy; 2) rare tumor type or atypical presentation of a common tumor; and/or 3) ≥3 primary malignancies. Cancer family history and clinicopathologic data were independently reviewed by a clinical genetic counselor to determine whether the patient met established criteria for testing for a hereditary cancer syndrome.RESULTSSequencing identified approximately 3500 variants. Nine protein‐truncating deleterious mutations were found across 6 genes, including BRCA2, ataxia telangiectasia mutated (ATM), mutL homolog 1 (MLH1), BRCA1 interacting protein C‐terminal helicase 1 (BRIP1), partner and localizer of BRCA2 (PALB2), and fibroblast growth factor receptor 3 (FGFR3). Likely pathogenic missense variants were identified in checkpoint kinase 2 (CHEK2) and homeobox protein Hox‐B13 (HOXB13). In total, 11 of 102 patients (10.8%) were found to have pathogenic or likely pathogenic mutations in cancer‐predisposing genes. The majority of these men (64%) did not meet current clinical criteria for germline testing.CONCLUSIONSMen with prostate cancer and at least 1 additional primary cancer are enriched for harboring a germline deleterious mutation in a cancer‐predisposing gene that may impact cancer prognosis and treatment, but the majority do not meet current criteria for clinical genetic testing. Cancer 2017;123:3925‐32. © 2017 American Cancer Society.
GPU processing of theta‐joins
Authors: Bellas Christos , Gounaris Anastasios 
Published: June 2017

SummaryThe GPGPU paradigm has recently been employed to accelerate the processing of big amounts of data through the utilization of the massive parallelism offered by modern GPUs. To date, several techniques have been proposed for the implementation of simple select, aggregate, and equality join operations on GPUs. In this paper, we study the efficient implementation of theta‐join queries between two relations using the CUDA framework. Theta‐joins are notoriously slow and thus can benefit from massively parallel execution. However, their GPU‐based implementation significantly differs from hash‐ and sort‐based equality joins and needs to be carefully crafted. The implementation is driven by two main objectives. The first relates to the attainment of high efficiency in the parallelization through data reuse, which relates to the minimization of accesses to the slow global memory. The second is about the most efficient exploitation of the available memory given that, in general, it cannot hold the entire input and result. We propose a methodology for processing theta‐joins on a GPU, which exploits the heterogeneous nature of GPGPU, while addressing memory limitations. Furthermore, we provide a series of implementation optimizations, which yield performance improvements of an order of magnitude.
The impact of social capitals on service quality of Chinese educational institutions: A multilevel analysis
Authors: Li Zhichao , Gan Siyun , Jia Ru 
Published: June 2017

SummaryMost of the existed researches of educational service quality are concentrated on the definition of service quality in education, measurement methods and the establishment of scales, or on student perception of service quality and its implication, while researches on the causes of educational service quality are quite scarce. In this study, the discussion on the causes of educational service quality was complemented from the perspective of social network, especially through analysis at the team level. A total of 478 copies of social network questionnaires were collected from 15 educational teams. Meanwhile, targeting at the educational institutions' customers, the service quality survey was conducted with 1,487 copies of valid samples in total. The results indicate that individual‐level social capital in the form of trust relations positively influences educational service quality. Among the group level factors, group centrality and number of cliques have a significant impact on group members' service quality, which also moderate the effect of trust on service quality.
Habitat age influences metacommunity assembly and species richness in successional pond ecosystems
Authors: Sferra Christopher O. , Hart Justin L. , Howeth Jennifer G. 
Published: June 2017

AbstractMetacommunity theory suggests that species diversity can depend upon the time since initiation of community assembly, or habitat age, as the relative influence of regional and local structuring processes changes over succession. There are, however, few studies that evaluate the role of habitat age in structuring species richness (diversity–age) over large, fine‐resolution age gradients of secondary succession in metacommunities. To test theoretical predictions of diversity–age relationships in metacommunities, zooplankton species richness and composition along a successional chronosequence in beaver (Castor canadensis) ponds were evaluated. The age of ponds was determined using dendrochronology and historical photography, and ranged from 23 to 69 yr of age. A unimodal relationship between zooplankton species richness and habitat age was observed among the successional ecosystems. This hump‐shaped relationship with community assembly time is congruent with theoretical predictions of species richness in metacommunities and can be explained by the increasing importance of local, relative to regional, structuring processes over successional trajectories. Observed patterns of diversity and composition responded to age‐mediated effects on the local pond environment; older ponds were deeper, had lower colored dissolved organic carbon, and were permanent. Additionally, there were weak but significant dispersal effects on community composition across the region. The lack of consistent community composition by successional stage reflected variation from differences in pond nutrient availability and species dispersal. The results indicate that regional and local age‐dependent structuring mechanisms operate at each successional stage on different local colonist pools and environments yielding communities that reflect succession in their richness response. Consequently, secondary succession should be considered an influential driver of species diversity across temporal and spatial scales in metacommunities.
Anxiety affects disability and quality of life in patients with painful diabetic neuropathy
Authors: Geelen C.C. , Smeets R.J.E.M. , Schmitz S. , van den Bergh J.P. , Goossens M.E.J.B. , Verbunt J.A. 
Published: June 2017

AbstractBackgroundPainful diabetic neuropathy (PDN) is known to negatively affect psychosocial functioning as expressed by enhanced levels of anxiety and depression. The aim of this study was to specify diabetes and pain‐related fears.MethodsThis questionnaire‐based cross‐sectional study included 154 patients with PDN (mean age 65.7 ± 6.6 years). Correlation analyses corrected for age, gender, pain intensity, pain duration and insulin treatment were performed to assess the associations of fear of hypoglycaemia (Hypoglycaemia Fear Survey, HFS), kinesiophobia (Tampa Scale of Kinesiophobia, TSK), fear of pain (Pain Anxiety Symptom Scale, PASS‐20), fear of falling (Falls Efficacy Scale‐I, FES‐I), fear of fatigue (Tampa Scale of Fatigue, TSF) and fear of negative evaluation (Brief Fear of Negative Evaluation Scale, BFNE), with quality of life (QoL) (Norfolk Quality of Life Questionnaire, Diabetic Neuropathy Version, QOL‐DN) and disability (Pain Disability Index, PDI), respectively.ResultsIn univariate analyses, all fears were independently associated with QOL‐DN and PDI (p < 0.001 for all variables). Linear regression models including all fears and confounders, showed that pain intensity, pain duration and FES‐I were significantly associated with QOL‐DN (R2 = 0.603). Pain intensity, male gender and FES‐I were significantly associated with PDI (R2 = 0.526).ConclusionsAfter controlling for confounders, levels of pain intensity, duration of pain and fear of falling were negatively associated with QoL in patients with PDN. Pain intensity, male gender and fear of falling were positively associated with disability. Specifying fears enables us to identify potential targets for behavioural interventions that aim to improve psychosocial well‐being in patients with PDN.SignificanceThis study shows that patients with PDN suffer from various fears, which should enable us to design a treatment strategy that directly targets these fears, hereby improving physical and psychosocial well‐being in these patients.