bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine hearing for predictive maintenance of BLDC motors
Authors: Prieto Rommel Stiward , Bravo Montenegro Diego Alberto , Rengifo Carlos 
Published: September 2024

PurposeThe purpose of this paper is to approach predictive maintenance (PdM) of brushless direct current (BLDC) motors using audio signal processing and extracting statistical and spectral features to train classical machine learning (ML) models.Design/methodology/approachThe proposed methodology relies on classification predictive model that shows the motors prone to failure. To verify this, the model was implemented and tested with audio data. The trained models are then deployed to an Industrial Internet of Things (IIoT) application built using Django.FindingsThe implementation of the methodology allows for achieving performance as high as 92% accuracy, proving that spectral features should be considered when training ML models for PdM.Originality/valueThe proposed model is an effective decision-making tool that provides an ideal solution for preventive maintenance scheduling problems for BLDC motors.
Thermophoretic particle deposition and double-diffusive mixed convection flow in non-Newtonian hybrid nanofluids past a vertical deformable sheet
Authors: Alharbi Latifah Falah , Khan Umair , Zaib Aurang , Shah S.H.A.M. , Ishak Anuar , Muhammad Taseer 
Published: September 2024

PurposeThermophoresis deposition of particles is a crucial stage in the spread of microparticles over temperature gradients and is significant for aerosol and electrical technologies. To track changes in mass deposition, the effect of particle thermophoresis is therefore seen in a mixed convective flow of Williamson hybrid nanofluids upon a stretching/shrinking sheet.Design/methodology/approachThe PDEs are transformed into ordinary differential equations (ODEs) using the similarity technique and then the bvp4c solver is employed for the altered transformed equations. The main factors influencing the heat, mass and flow profiles are displayed graphically.FindingsThe findings imply that the larger effects of the thermophoretic parameter cause the mass transfer rate to drop for both solutions. In addition, the suggested hybrid nanoparticles significantly increase the heat transfer rate in both outcomes. Hybrid nanoparticles work well for producing the most energy possible. They are essential in causing the flow to accelerate at a high pace.Practical implicationsThe consistent results of this analysis have the potential to boost the competence of thermal energy systems.Originality/valueIt has not yet been attempted to incorporate hybrid nanofluids and thermophoretic particle deposition impact across a vertical stretching/shrinking sheet subject to double-diffusive mixed convection flow in a Williamson model. The numerical method has been validated by comparing the generated numerical results with the published work.
Additive manufacturing of titanium–diamond parts: insights into the laser metal deposition process, powder rheology, mechanical properties and osteoblast cell viability
Authors: Mani Nour , Tran Nhiem , Jones Alan , Mirabedini Azadeh , Houshyar Shadi , Fox Kate 
Published: September 2024

Purpose
The purpose of this study is therefore to detail an additive manufacturing process for printing TiD parts for implant applications. Titanium–diamond (TiD) is a new composite that provides biocompatible three-dimensional multimaterial structures. Thus, the authors report a powder-deposition and print optimization strategy to overcome the dual-functionality gap by printing bulk TiD parts. However, despite favorable customization outcomes, relatively few additive manufacturing (AM) feedstock powders offer the biocompatibility required for medical implant and device technologies.

Design/methodology/approach
AM offers a platform to fabricate customized patient-specific parts. Developing feedstock that can be 3D printed into specific 3D structures while providing a favorable interface with the human tissue remains a challenge. Using laser metal deposition, feedstock powder comprising diamond and titanium was co-printed into TiD parts for mechanical testing to determine optimal manufacturing parameters.

Findings
TiD parts were fabricated comprising 30% and 50% diamond. The composite powder had a Hausner ratio of 1.13 and 1.21 for 30% and 50% TiD, respectively. The flow analysis (Carney flow) for TiD 30% and 50% was 7.53 and 5.15 g/s. The authors report that the printing-specific conditions significantly affect the integrity of the printed part and thus provide the optimal manufacturing parameters for structural integrity as determined by micro-computed tomography, nanoindentation and biocompatibility of TiD parts. The hardness, ultimate tensile strength and yield strength for TiD are 4–6 GPa (depending on build position), 426 MPa and 375 MPa, respectively. Furthermore, the authors show that increasing diamond composition to 30% results in higher osteoblast viability and lower bacteria count than titanium.

Originality/value
In this study, the authors provide a clear strategy to manufacture TiD parts with high integrity, performance and biocompatibility, expanding the material feedstock library and paving the way to customized diamond implants. Diamond is showing strong potential as a biomedical material; however, upscale is limited by conventional techniques. By optimizing AM as the avenue to make complex shapes, the authors open up the possibility of patient-specific diamond implant solutions.
Acute aconitine poisoning resulting from the ingestion of medicinal liquor
Authors: Huang Ruoyu , Pang Qiuyu , Zheng Lexin , Duan Rui , Wang Ying , Wang Zhiyong , Wang Tao 
Published: September 2024

AbstractDiester diterpenoid alkaloids (DDAs) are the main active ingredients of herbaceous perennial plants Aconitum. DDAs possess cardiotoxic and neurotoxic properties. Although most deaths caused by DDA poisoning are accidental, a few instances of suicide and homicide have been reported. Presented is a case of an acute aconitine (AC) poisoning following the ingestion of approximately 50 mL of homemade medicinal liquor. We described the clinical manifestations after poisoning and detailed postmortem changes, and detected the concentrations of AC and hypaconitine (HA) by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The decedent experienced a burning sensation in the gastrointestinal tract after poisoning, followed by flushing and paralysis of the face and limbs, and severe cardiac arrhythmia. An autopsy revealed cyanosis of the lips and nail beds; conjunctival hemorrhage in both eyes; pulmonary edema; tissue hemorrhage and congestion in multiple organs; and inflammatory cell infiltration in the stomach, duodenum, pancreas, and cardiac muscle. The concentrations of AC and HA were as follows: cardiac blood, 38.4 ng/mL and 7.1 ng/mL; pericardial fluid, 7.3 ng/mL and 41 ng/mL; urine, 28.1 ng/mL and 574 ng/mL; bile, 38.5 ng/mL and 108 ng/mL; gastric contents, 0.06 mg and 0.56 mg; liver tissue, 10.7 ng/g and 109.6 ng/g; and medicinal liquor, 0.568 mg/mL and 0.664 mg/mL, respectively. The clinical manifestations, anatomy findings, and quantitative data on the concentrations of AC and HA in body fluids and tissues will aid forensic investigations of deaths caused by acute AC poisoning.
The relationship between changes in peritoneal permeability with CA‐125 and HIF‐1α
Authors: Koyuncu Sumeyra , Sipahioğlu Hilal , Karakukcu Cigdem , Zararsız Gökmen , İçaçan Gamze , Biçer Nazmiye Serap , Kocyigit Ismail 
Published: September 2024

AbstractBackgroundPeritoneal fibrosis (PF) is a major, persistent complication of prolonged peritoneal dialysis that eventually leads to peritoneal ultrafiltration failure and termination of peritoneal dialysis. Prolonged exposure to high glucose concentrations, degradation products, uremic toxins, and episodes of peritonitis can cause some changes in the peritoneal membrane, resulting in intraperitoneal inflammation and PF, leading to failure of ultrafiltration and dialysis. CA‐125 can be used as a biomarker of peritoneal mesothelial cell count in the peritoneal dialysate and for monitoring cell count in PD patients. Hypoxia‐inducible factor 1‐alpha (HIF‐1α) has been reported to cause PF, but has not been reported to be associated with changes in peritoneal structure. We hypothesized that peritoneal adequacy can be followed using HIF‐1α and CA‐125 values. In the present study, therefore, we investigated the relationship between HIF‐1α and CA‐125 levels and parietal membrane permeability changes in PD patients.MethodsForty‐five patients were included in the study. Peritoneal permeability was constant in 20 of these, while peritoneal permeability increased in 11 and decreased in 14. The HIF‐1α value from the blood samples of the patients and the CA‐125 measurement from the peritoneal fluids were measured. The relationship between peritoneal variability and CA‐125 and HIF levels after follow‐up was investigated.ResultsWe compared serum HIF‐1α and peritoneal fluid CA‐125 levels in the three groups receiving peritoneal dialysis treatment. HIF‐1α levels increased with peritoneal permeability changes, while CA‐125 levels decreased. In patients with high to low permeability changes, HIF‐1α levels were higher compared to those with stable or low to high changes, which was statistically significant. Conversely, CA‐125 levels significantly decreased in patients whose peritoneal permeability changed from high to low, compared to the other two groups.ConclusionChanges in peritoneal structure can be followed with biomarkers. It has been shown that CA‐125 and HIF‐1α levels can guide the changes in the peritoneal membrane. This can be useful in the monitoring of peritoneal dialysis.
Blockade of dopamine D3 receptors improves hippocampal synaptic function and rescues age‐related cognitive phenotype
Authors: Tropea Maria Rosaria , Melone Marcello , Li Puma Domenica Donatella , Vacanti Valeria , Aceto Giuseppe , Bandiera Bruno , Trovato Roberta Carmela , Torrisi Sebastiano Alfio , Leggio Gian Marco , Palmeri Agostino , D'Ascenzo Marcello , Conti Fiorenzo , Grassi Claudio , Puzzo Daniela 
Published: September 2024

AbstractDopamine D3 receptors (D3Rs) modulate neuronal activity in several brain regions including the hippocampus. Although previous studies reported that blocking D3Rs exerts pro‐cognitive effects, their involvement in hippocampal synaptic function and memory in the healthy and aged brain has not been thoroughly investigated. We demonstrated that in adult wild type (WT) mice, D3R pharmacological blockade or genetic deletion as in D3 knock out (KO) mice, converted the weak form of long‐term potentiation (LTP1) into the stronger long‐lasting LTP (LTP2) via the cAMP/PKA pathway, and allowed the formation of long‐term memory. D3R effects were mainly mediated by post‐synaptic mechanisms as their blockade enhanced basal synaptic transmission (BST), AMPAR‐mediated currents, mEPSC amplitude, and the expression of the post‐synaptic proteins PSD‐95, phospho(p)GluA1 and p‐CREB. Consistently, electron microscopy revealed a prevalent expression of D3Rs in post‐synaptic dendrites. Interestingly, with age, D3Rs decreased in axon terminals while maintaining their levels in post‐synaptic dendrites. Indeed, in aged WT mice, blocking D3Rs reversed the impairment of LTP, BST, memory, post‐synaptic protein expression, and PSD length. Notably, aged D3‐KO mice did not exhibit synaptic and memory deficits. In conclusion, we demonstrated the fundamental role of D3Rs in hippocampal synaptic function and memory, and their potential as a therapeutic target to counteract the age‐related hippocampal cognitive decline.
Review article: Faecal biomarkers for assessing small intestinal damage in coeliac disease and environmental enteropathy
Authors: Kivelä Laura , Lindfors Katri , Lundin Knut E. A. , Størdal Ketil 
Published: September 2024

SummaryBackgroundIn coeliac disease and environmental enteropathy, dietary gluten and enteric infections cause reversible inflammation and morphological changes to the small intestinal mucosa that can be detected in biopsy samples obtained by endoscopy. However, there is a clear need for non‐invasive biomarkers. Constant shedding of mucosal material into the bowel lumen and faeces, together with easy availability of stool, makes it an interesting sample matrix.AimsTo conduct a systematic literature search and summarize the existing evidence for host mucosa‐derived faecal biomarkers in evaluating small intestinal damage.MethodsWe searched for studies on PubMed (MEDLINE) until 1 March 2024.ResultsWe identified 494 studies and included 35 original case–control and cohort studies. These assessed host mucosal transcripts and 14 other markers aiming specifically to reflect inflammation and cell‐mediated, innate and gluten‐induced immune responses. In coeliac disease, faecal calprotectin and anti‐gliadin, tissue transglutaminase, endomysium and deamidated gliadin peptide antibodies were the most studied but with inconsistent results. Single studies reported positive findings about microRNA transcripts, β‐defensin‐2, lipocalin‐2, zonulin‐related proteins and angiotensin‐converting enzyme. In environmental enteropathy, a non‐significant association was reported between calprotectin and urine lactulose/mannitol ratio; there were conflicting results for neopterin, myeloperoxidase and host transcripts. Single studies reported a positive association for lactoferrin, and a negative association for regenerating islet‐derived protein 1. Studies comparing faecal markers against small intestinal biopsy findings were not identified in environmental enteropathy.ConclusionsFurther studies are needed to determine reliable faecal markers as a proxy for small intestinal mucosal damage.
Letter: Optimising public health policies to combat alcohol‐associated liver disease in youth—Authors' reply
Authors: Danpanichkul Pojsakorn , Tothanarungroj Primrose , Diaz Luis Antonio , Arab Juan Pablo , Liangpunsakul Suthat , Wijarnpreecha Karn 
Published: September 2024

LINKED CONTENTThis article is linked to Danpanichkul et al papers. To view these articles, visit https://doi.org/10.1111/apt.18101 and https://doi.org/10.1111/apt.18239
Elucidation of the Microwave‐Assisted Synthesis and Characterization of Heteronuclear Complexes of Bisbenzimidazole Derivatives and Their Biological Activities by In Vitro and In Silico Assays
Authors: Kaplan Esra , Koc Ziya Erdem , Uysal Ahmet , Uba Abdullahi Ibrahim , Zengin Gokhan 
Published: September 2024

ABSTRACTA novel and efficient protocol for the microwave‐assisted synthesis of diversely substituted 2,2′‐bisbenzimidazol‐5,6′‐dicarboxylic acid (BIMCA) from the reaction of 3,4‐diaminobenzoic acid with oxalic acid has been developed, which proceeds through sequential nucleophilic addition and electrophilic substitution in accordance with the Philips method. The synthetic utility of this strategy was demonstrated by the concise, one‐pot synthesis of (BIMCA) and metal complexes. (BIMCA) with a [{Fe(salen)}2O] Schiff base ligand complex and new benzimidazole coordination compounds with double oxygen [(BIMCA){Fe(salen)}2] ligand complexes were obtained. The resulting [(BIMCA){Fe(salen)}2] ligand complex was then synthesized from Co(CH3COO)2.4H2O, Ni(CH3COO)2.4H2O and Cu(CH3COO)2.H2O heteronuclear complexes. The condensations proceed with good yield to give products that, in certain instances, are not readily attainable by conventional condensation techniques. The structures of the compounds were identified by Fourier‐transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR), elemental analysis and magnetic susceptibility. The mutagenic potential of the synthesized chemicals was evaluated by the Ames test towards mutant Salmonella typhimurium strains TA98 and TA100. It was recorded that these chemicals had no mutagenic action. Also, antimicrobial activities were screened by broth microdilution test. It was seen that the minimum inhibitory concentration (MIC) against Klebsiella pneumoniae, Staphylococcus aureus and Staphylococcus epidermidis was 0.195 mg/mL, followed by a MIC value of 0.390 mg/mL against Escherichia coli and Salmonella typhimurium. [(BIMCA){Fe(salen)}2Co(II)] demonstrated significant antimicrobial activity against Proteus mirabilis and Staphylococcus aureus, with an MIC of 0.195 mg/mL, followed by an MIC of 0.390 mg/mL against Pseudomonas aeruginosa, K. pneumonia and Salmonella typhimurium. The antioxidant properties were examined using various chemical assays, and [(BIMCA){Fe(salen)}2O] and (BIMCA) exhibited greater 2,2'‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging ability, when compared with other compounds. Enzyme inhibitory effects were tested against acetylcholinesterase (AChE), amylase, butyrylcholinesterase (BChE) and tyrosinase. [(BIMCA){Fe(salen)}2Cu(II)] displayed the best AChE (IC50 0.51 mg/mL), BChE (IC50 0.51 mg/mL) and tyrosinase (IC50 1.52 mg/mL) inhibitory effects. Furthermore, molecular docking calculations were performed to gain insights into the interaction between [(BIMCA){Fe(salen)}2] and AChE, and between [(BIMCA){Fe(salen)}2Cu(II)] and amylase. Both compounds showed the potential inhibition of the protein targets.
Let's put the clues together and find the aetiology in this patient with dilated right heart!
Authors: Inan Duygu , Hadi Omer Abdel , Yildiz Ufuk , Bas Serap , Kılıcgedik Alev 
Published: September 2024

AbstractA 39‐year‐old woman with intermittent palpitations, psoriasis, and a family history of sudden death presented with dilated right heart chambers and an enlarged coronary sinus. Despite a normal bubble study, further evaluation with transesophageal echocardiography revealed an abnormal pulmonary venous return: the left pulmonary veins drained into the coronary sinus. Cardiac computed tomography confirmed this finding, suggesting a partial abnormal pulmonary venous return as the underlying issue. Cardiac catheterization indicated increased pulmonary artery flow with normal pulmonary vascular resistance. The patient was referred for surgery. In this pathway involving the differential diagnosis of right heart dilatation, despite a confusing history and conflicting findings, echocardiographic clues led to the diagnosis.
Patient‐reported daily functioning after SARS‐CoV‐2 vaccinations in autoimmune neuromuscular diseases
Authors: van Dam Koos P. J. , Wieske Luuk , Stalman Eileen W. , Kummer Laura Y. L. , van der Kooi Anneke J. , Raaphorst Joost , van de Beek Diederik , Verschuuren Jan J. G. M. , Ruiter Annabel M. , Brusse Esther , van Doorn Pieter A. , Baars Adája E. , van der Pol W. Ludo , Goedee H. Stephan , ten Brinke Anja , van Ham S. Marieke , Rispens Theo , Kuijpers Taco W. , Eftimov Filip ,   the T2B! Immunity Against SARS‐CoV‐2 Study Group
Published: September 2024

AbstractBackground and purposeThere are concerns for safety regarding SARS‐CoV‐2 vaccines for patients with autoimmune neuromuscular disease. We compared daily functioning using disease‐specific patient‐reported outcome measures (PROMs) before and after SARS‐CoV‐2 vaccinations.MethodsIn this substudy of a prospective observational cohort study (Target‐to‐B!), patients with myasthenia gravis (MG), chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN), and idiopathic inflammatory myopathy (IIM) vaccinated against SARS‐CoV‐2 were included. Surveys of daily functioning (Myasthenia Gravis Activities of Daily Living, Inflammatory Rasch‐Built Overall Disability Scale, Multifocal Motor Neuropathy Rasch‐Built Overall Disability Scale, and Health Assessment Questionnaire–Disability Index) were sent before first vaccination and every 60 days thereafter for up to 12 months. Regression models were constructed to assess differences in PROM scores related to vaccination, compared to scores unrelated to vaccination. We also assessed the proportion of patients with deterioration of at least the minimal clinically important difference (MCID) between before first vaccination and 60 days thereafter.ResultsWe included 325 patients (median age = 59 years, interquartile range = 47–67, 156 [48%] female sex), of whom 137 (42%) had MG, 79 (24%) had CIDP, 43 (13%) had MMN, and 66 (20%) had IIM. PROM scores related to vaccination did not differ from scores unrelated to vaccination. In paired PROMs, MCID for deterioration was observed in three of 49 (6%) MG patients, of whom none reported a treatment change. In CIDP, MCID for deterioration was observed in eight of 29 patients (28%), of whom two of eight (25%) reported a treatment change.ConclusionsSARS‐CoV‐2 vaccination had no effect on daily functioning in patients with autoimmune neuromuscular diseases, confirming its safety in these patients.
Effectiveness and safety of monthly versus quarterly fremanezumab for migraine prevention: An Italian, multicenter, real‐life study
Authors: Zanandrea Laura , Messina Roberta , Cetta Ilaria , Genovese Federica , Guerrieri Simone , Vernieri Fabrizio , Altamura Claudia , Cevoli Sabina , Favoni Valentina , Colombo Bruno , Filippi Massimo 
Published: September 2024

AbstractBackground and PurposeFremanezumab, a monoclonal antibody targeting the calcitonin gene‐related peptide for migraine prevention, is available in monthly (225 mg) and quarterly (675 mg) doses. Previous studies showed efficacy and safety for both regimens, but a real‐life comparison is lacking. This study aimed to compare the effectiveness and safety of monthly and quarterly fremanezumab in a real‐life setting.MethodsThis Italian, prospective, multicenter study enrolled 95 migraine patients. During a 3‐month treatment period, patients received either monthly or quarterly fremanezumab (49 monthly, 46 quarterly). A 6‐month treatment period involved 79 patients (43 monthly, 36 quarterly). Monthly headache (MHD) and migraine days (MMD), number of days (AMD) and pills (AMP) of acute medication intake, and Headache Impact Test (HIT‐6), Migraine Disability Assessment (MIDAS) test, and Numeric Rating Scale (NRS) scores were recorded at baseline and after 3 and 6 months of treatment. Adverse events (AEs), responder rates, and medication overuse were also investigated.ResultsBoth monthly and quarterly treatments led to significant reductions in MMD, MHD, AMP, AMD, HIT‐6, MIDAS, and NRS scores after 3 and 6 months. The monthly regimen exhibited a slightly greater reduction in MMD and MHD after the first quarter, with no significant difference observed after 6 months. The most common AE was transient injection‐site reaction, without between‐group differences. Responder rates and resolution of medication overuse did not significantly differ between the groups.ConclusionsBoth monthly and quarterly regimens were effective and safe, with a tendency for an advantage of the monthly regimen only in the first quarter of treatment.