bluuebunny/crossref_metadata_2025_split huggingface dataset:
West Kendall Baptist Hospital: meeting the demand of community-based healthcare in the new (and stormy) regulatory environment
Authors: Weismann Miriam , Hernandez Lichtl Javier , Pierce Heather , Harris Denise , Boue Lourdes , Campbell Cathy 
Published: October 2017

Synopsis
The first three years of operation of the West Kendall Baptist Hospital (WKBH) in Miami, Florida provided a “poster child” for efficient and cost effective healthcare delivery to the West Kendall community that it served. The hospital leadership and management team exemplified a quality-oriented staff that moved as a cohesive and dedicated organization. WKBH exceeded every budget prediction and showed a profit in year 3, well before expected. Then came the winds of regulatory change. With the passage of the Affordable Care Act (ACA) and the attendant imposition of new reimbursement metrics, the picture at WKBH changed almost overnight. By the first quarter of 2016, WKBH started to lose money in excess of budget predictions despite its increased patient admissions, careful financial planning, expense reductions, quality service, and excellence in patient care delivery. A serious financial crisis was looming with little relief in sight. The hospital management team began to search for solutions.

Research methodology
The research methodology includes collecting quantitative data: original financial statements and financial data from WKBH, as well as qualitative data: interviews of hospital administrators and historical information.

Relevant courses and levels
Graduate capstone course in a finance course; masters in health administration; and/or the MBA program.

Theoretical bases
While it is clear that the ACA was designed with all good intentions, it has created substantial and perhaps, unanticipated financial burdens for caregivers. These issues are not only faced by WKBH. Most hospitals could relate to one or more of the four questions examined as part of this learning process. Graduate MBA students worked with the hospital to identify, define, focus, and resolve difficult quantitative and qualitative issues faced by the hospital as a result of major changes in the regulatory environment with the passage of the ACA. This case focuses upon the current reimbursement environment that has only recently emerged as a result of the implementation of the ACA.
Comparing two approaches to team building: a performance measurement evaluation
Authors: Ciasullo Maria Vincenza , Cosimato Silvia , Gaeta Matteo , Palumbo Rocco 
Published: October 2017

Purpose
This paper reports a study that compares two different team-building approaches. The first one is the traditional top-down management approach. The second one is a hybrid bottom-up approach based on the consensus model. The aim of this paper is to determine which of the two approaches is the most effective across a number of performance measurements.

Design/methodology/approach
A case study is presented using data collected and analysed from a small family-owned vehicle maintenance firm. A mixed methods approach to data collection is utilized, including participant observation, focus groups, survey questionnaires and organizational performance reports. A convenience sample of eight routine maintenance jobs was selected for team performance comparison purposes. The measures used for comparing the two team approaches were lead time, customer satisfaction ratings and employees’ satisfaction ratings.

Findings
The teams assembled using the consensus approach performed better than those selected using the traditional top-down approach across all three performance measures, i.e. the jobs were completed faster and both customers and employees were more satisfied.

Research limitations/implications
This is an exploratory case study limited to one small family-owned business and, as such, findings may not be generalizable.

Practical implications
As an alternative to manager selected work teams, managers should involve and empower employees to select their own teams. This has the potential to offer benefits for both customers and employees of faster delivery times and increase satisfaction, as well as increase productivity for the firm.

Originality/value
This is the first field study to compare the performance of a hybrid, bottom-up approach to team building with the performance of a more traditional management, top-down approach to team building. It paves the way for a wider study to be conducted in the future to test the findings’ generalizability.
Towards enhancing innovation capability of teams: a conceptual perspective
Authors: Tikas Gaurav Dilip , K.B. Akhilesh 
Published: October 2017

PurposeThis conceptual paper aims to explain the unidirectional cross-level impact of five “organizational-level” factors on “team-level” innovation capability through two “team-level” mediating factors. This multivariate model consists of five organizational-level factors (higher-level) factors – leadership, culture, structure, networks and knowledge – and team-level (lower-level) factors – “innovation capability”, “team-level focus” and “team-level intensity” towards innovation. Understanding the top-down influence of higher-level factors on lower-level ones gives this study a cross-level and unidirectional nature.Design/methodology/approachA keyword-based approach was used to select “relevant” articles from major journals to collect evidences and develop a conceptual model. All factors in the conceptual model were chosen from the organizational- and the team-level literature. Theoretical background for each of the chosen “factors” has been presented under relevant headings.FindingsFirst is the conceptualization of team-level mediators – intensity and focus – towards innovation. Second is the conceptualization of innovation capability as a team-level factor, characterized by two sub-dimensions: customer orientation and manifestation.Research limitations/implicationsThis conceptual paper does not contain any empirical data analysis. The authors have not considered individual-level factors like individual excellence, personalities, etc., which may impact team-level innovation. They are specifically looking at the top-down “unidirectional” cross-level impact of “higher-level” (organizational-level) factors on “lower-level” (team-level) factor, not the other way around.Practical implicationsInnovation-driven organizations can use this model to build long-term “innovation capabilities” by developing the right kind of “intensity” and “focus” of their R&D teams towards innovation. R&D teams can be encouraged to work closely with their “target” customers and manifest their innovation capabilities (to them) to ensure market success.Social implicationsTop management can design organizational-level policies to improve their leadership, culture, structure, networks and knowledge to encourage better innovation. Future researchers who wish to study the “cross-level” influence of organizational-level factors on team-level innovation capability may find this paper useful.Originality/valueThis study’s original contributions include: first, the conceptualization of a multivariate “cross-level” model to understand team-level innovation capability. Second is proposing the mediating role of “team-level” factors like focus and intensity while building innovation capability. Third is conceptualizing innovation capability as a team-level construct, with sub-dimensions: customer orientation and manifestation.
Productivity dynamics and the cleansing effect of two recessions: Evidence from the manufacturing sector in Korea
Authors: Lee Hun Jun , Lee Jeong‐Dong , Baek Chulwoo 
Published: October 2017

AbstractIn general, recessions provoke the exit of a greater number of firms from the market. Less productive firms are more likely to exit and release their former resources to the remaining, more productive firms. The present study investigates two recessions in Korea: the Asian financial crisis and the global financial crisis. The main objective of the present study is to analyse the process of creative destruction in a recession, specifically the cleansing effect. We measured total factor productivity using micro‐level manufacturing plant data from 1993 to 2013. We decomposed the source of the changes in total factor productivity to measure the cleansing effect in two large recessions. During the first recession in the 1990s, there was no evidence to support a cleansing effect hypothesis. In contrast, during the second recession in the 2000s, there was evidence of a cleansing effect. In addition, we found differences in market selection criteria in the two recessions; by the second crisis, the market selection criteria had changed to enable a more conducive environment for the creative destruction process.
Effect of whey protein‐iron based edible coating on the quality of Paneer and process optimisation
Authors: Jotarkar Parameshwar S , Panjagari Narender R , Singh Ashish K , Arora Sumit 
Published: October 2017

Whey protein concentrate (WPC)‐based edible coating containing one of the four different iron salts was used to enhance the nutritional quality of Paneer in the study. Ferric ammonium citrate containing WPC coating solutions decreased the L* but increased a* and b*. Principal component analysis identified three significant principal components that accounted for 88.85% of the variation in the sensory and instrumental colour data. Response surface methodology predicted that maximum iron content in Paneer (93.5 ppm) could be achieved with 100 mL of dipping volume, 1.5 cm of cube size and 10‐min dipping time as processing parameters.
Symbols of priority? How the media selectively report on parties’ election campaigns
Authors: GREENE ZACHARY , LÜHISTE MAARJA 
Published: October 2017

AbstractLeaders and members of parliament serve as a political party's public face. Their image casts a shadow in which observers interpret policy statements. It is hypothesized in this article that media cover and voters understand policy messages through the lens of prominent party members’ characteristics. Easy‐to‐observe descriptive traits, such as gender or ethnicity, cue parties’ policy priorities. Media are more likely to emphasise party messages on issues historically related to these groups when they are visible in the party's public image. Hypotheses from this theory are tested using data on prominent party members’ descriptive characteristics, policy statements and media coverage of statements from the European Election Studies. Data from the 1999, 2004 and 2009 European elections evidence support for the theory. Parties with more female representatives signal stronger emphasis on gendered issues in media reports. The results hold implications for understanding the ways in which parties deliver and voters receive campaign messages. This research offers an explanation for voters’ limited knowledge of parties’ policy positions; media reinforce existing gender stereotypes and voters’ predispositions by selectively reporting policy statements.
The Relationship Between Gambling Severity and Risk of Criminal Recidivism
Authors: April Laura M. , Weinstock Jeremiah 
Published: October 2017

AbstractIndividuals involved with the criminal justice system have the highest prevalence of gambling disorder. Yet, this is an understudied area, especially in relation to postrelease functioning and recidivism risk. Participants (N = 100) were recruited from a local nonprofit organization and a federal probation office. Participants completed both self‐report and interviewer‐administered questionnaires assessing past‐year and lifetime gambling behaviors and problems, legal history, health, and risk of recidivism. Past‐year (8%) and lifetime (18%) rates of gambling disorder among the current sample are significantly greater than those of the general population and similar to rates found in incarcerated populations. Furthermore, 13% of individuals reported a direct relationship between their gambling and crime, and analyses revealed that increased gambling severity was a significant predictor of increased recidivism risk. Results suggest the need for screening and intervention efforts and call for policy reform among incarcerated and ex‐offender populations.
FGF23 Level and Intima‐Media Thickness Are Elevated From Early Stages of Chronic Kidney Disease
Authors: Figurek Andreja , Spasovski Goce , Popovic‐Pejicic Snjezana 
Published: October 2017

AbstractConsidering high cardiovascular (CV) risk in chronic kidney disease (CKD), the aim of this cross‐sectional study was to assess the association between carotid intima‐media thickness (IMT) and fibroblast growth factor (FGF) 23 as important players in CV pathophysiology. Eighty‐seven patients with mean estimated glomerular filtration rate 40.1 mL/min per 1.73 m2 were involved. FGF23 and IMT were elevated from early stages of CKD. Mean IMT value was 1.10 ± 0.20 mm, being significantly elevated starting from early CKD, showing no correlation with FGF23 (r = −0.01, P = −0.91). Unlike the FGF23 level that followed worsening of kidney function, IMT was increasing only in the initial CKD stages, with no further increase from CKD stage 3 on. Although we found no direct association between current use of vitamin D and statin therapy, this may be associated with the sustained reference values of lipid and vitamin D status under treatment that further preclude worsening of IMT in patients with advanced CKD.
Communicating Value in Simulation: Cost–Benefit Analysis and Return on Investment
Authors: Asche Carl V. , Kim Minchul , Brown Alisha , Golden Antoinette , Laack Torrey A. , Rosario Javier , Strother Christopher , Totten Vicken Y. , Okuda Yasuharu 
Published: October 2017

AbstractValue‐based health care requires a balancing of medical outcomes with economic value. Administrators need to understand both the clinical and the economic effects of potentially expensive simulation programs to rationalize the costs. Given the often‐disparate priorities of clinical educators relative to health care administrators, justifying the value of simulation requires the use of economic analyses few physicians have been trained to conduct. Clinical educators need to be able to present thorough economic analyses demonstrating returns on investment and cost‐effectiveness to effectively communicate with administrators.At the 2017 Academic Emergency Medicine Consensus Conference “Catalyzing System Change through Health Care Simulation: Systems, Competency, and Outcomes,” our breakout session critically evaluated the cost‐benefit and return on investment of simulation. In this paper we provide an overview of some of the economic tools that a clinician may use to present the value of simulation training to financial officers and other administrators in the economic terms they understand. We also define three themes as a call to action for research related to cost–benefit analysis in simulation as well as four specific research questions that will help guide educators and hospital leadership to make decisions on the value of simulation for their system or program.
Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine
Authors: Bernstein David L. , Badve Preeti S. , Barson Jessica R. , Bass Caroline E. , España Rodrigo A. 
Published: October 2017

AbstractThe hypocretin receptor 1 (HCRTr1) is a critical participant in the regulation of motivated behavior. Previous observations demonstrate that acute pharmacological blockade of HCRTr1 disrupts dopamine (DA) signaling and the motivation for cocaine when delivered systemically or directly into the ventral tegmental area (VTA). To further examine the involvement of HCRTr1 in regulating reward and reinforcement processing, we employed an adeno‐associated virus to express a short hairpin RNA designed to knock down HCRTr1. We injected virus into the VTA and examined the effects of HCRTr1 knockdown on cocaine self‐administration and DA signaling in the nucleus accumbens (NAc) core. We determined that the viral approach was effective at reducing HCRTr1 expression without affecting the expression of hypocretin receptor 2 or DA‐related mRNAs. We next examined the effects of HCRTr1 knockdown on cocaine self‐administration, observing delayed acquisition under a fixed‐ratio schedule and reduced motivation for cocaine under a progressive ratio schedule. These effects did not appear to be associated with alterations in sleep/wake activity. Using fast‐scan cyclic voltammetry, we then examined whether HCRTr1 knockdown alters DA signaling dynamics in the NAc core. We observed reduced DA release and slower uptake rate as well as attenuated cocaine‐induced DA uptake inhibition in rats with knockdown of HCRTr1. These observations indicate that HCRTr1 within the VTA influence the motivation for cocaine, likely via alterations in DA signaling in the NAc.
Application of a Simplified Hand‐Sewn Trileaflet Valved Conduit in Right Ventricular Outflow Tract Reconstruction as an Alternative for Bovine Jugular Vein Graft: Single‐Center Experience
Authors: Zhang Hui‐Feng , Ye Ming , Yan Xian‐Gang , Chen Gang , Tao Qi‐Lin , Jia Bing 
Published: October 2017

AbstractThe Bovine jugular vein (BJV) graft for right ventricular outflow tract reconstruction (RVOT) is limited applied due to possible graft failure. In this study, we reported the clinical application of simplified hand‐sewn trileaflet valved conduit as an alternative for BJV graft. We retrospectively included 68 patients underwent 76 conduits implantation including 22 new simplified hand‐sewn trileaflet valved conduits (Group A) and 54 BJV grafts (Group B). For patients in Group A, a hand‐sewn trileaflet valved conduit with valves made of autologous pericardium or expanded polytetrafluoroethylene was applied. Baseline, perioperative, and outcomes were analyzed. No early mortality or perioperative complication occurred in Group A, while 2 patients died and 16 patients suffered from conduits failure due to conduits stenosis (n = 11), stenosis plus regurgitation (n = 3), and regurgitation alone (n = 2) in Group B. Freedom from BJV grafts failure within 1, 3, 5, and 7 years was 98.0%, 88.2%, 83.6% and 83.6% in Group A, and 98.0%, 85.8%, 76.8% and 62.1% in Group B. Endocarditis occurred in 9 patients in Group B, but not in Group A. Subsequent analysis showed that endocarditis is the only significant predictor of BJV grafts failure (odds ratio: 6.202, 95% confidence intervals 1.237∼31.108). The novel simplified hand‐sewn trileaflet valved conduits seems to be associated with lower incidences of perioperative complication, graft failure, and early‐phase mortality, as compared with conventional BJV grafts.
Effects of manipulating tetanic calcium on the curvature of the force‐velocity relationship in isolated rat soleus muscles
Authors: Kristensen A. M. , Nielsen O. B. , Overgaard K. 
Published: October 2017

AbstractAimIn dynamically contracting muscles, increased curvature of the force‐velocity relationship contributes to the loss of power during fatigue. It has been proposed that fatigue‐induced reduction in [Ca++]i causes this increased curvature. However, earlier studies on single fibres have been conducted at low temperatures. Here, we investigated the hypothesis that curvature is increased by reductions in tetanic [Ca++]i in isolated skeletal muscle at near‐physiological temperatures.MethodsRat soleus muscles were stimulated at 60 Hz in standard Krebs‐Ringer buffer, and contraction force and velocity were measured. Tetanic [Ca++]i was in some experiments either lowered by addition of 10 μmol/L dantrolene or use of submaximal stimulation (30 Hz) or increased by addition of 2 mmol/L caffeine. Force‐velocity curves were constructed by fitting shortening velocity at different loading forces to the Hill equation. Curvature was determined as the ratio a/F0 with increased curvature reflecting decreased a/F0.ResultsCompared to control levels, lowering tetanic [Ca++]i with dantrolene or reduced stimulation frequency decreased the curvature slightly as judged from increase in a/F0 of 13 ± 1% (P = < .001) and 20 ± 2% (P = < .001) respectively. In contrast, increasing tetanic [Ca++]i with caffeine increased the curvature (a/F0 decreased by 17 ± 1%; P = < .001).ConclusionContrary to our hypothesis, interventions that reduced tetanic [Ca++]i caused a decrease in curvature, while increasing tetanic [Ca++]i increased the curvature. These results reject a simple causal relation between [Ca++]i and curvature of the force‐velocity relation during fatigue.
Dominant high expression of wild‐type HSP110 defines a poor prognostic subgroup of colorectal carcinomas with microsatellite instability: a whole‐section immunohistochemical analysis
Authors: Oh Hyeon Jeong , Kim Jung Ho , Lee Tae Hun , Park Hye Eun , Bae Jeong Mo , Lee Hye Seung , Kang Gyeong Hoon 
Published: October 2017

The aim of this study is to establish heat shock protein 110 (HSP110) as a prognostic biomarker of colorectal carcinomas (CRCs) with microsatellite instability‐high (MSI‐H) by considering the intratumoral heterogeneity of HSP110 expression. We performed whole‐section immunohistochemistry (IHC) for wild‐type HSP110 (HSP110wt) in 164 MSI‐H CRCs. The intensity of the HSP110wt expression in tumor cells was semiquantitatively scored (0/1/2/3), and the HSP110wt expression status of each tumor was classified as low or high using the following four scoring criteria: H‐score, dominant intensity score, lowest intensity score, and highest intensity score. Among the four criteria, only the dominant intensity score‐based dichotomous classification of HSP110wt expression was significantly associated with a difference in disease‐free survival (log‐rank p = 0.035) in 164 MSI‐H CRCs. The HSP110wt‐low MSI‐H CRCs were significantly correlated with larger deletions in the HSP110 T17 mononucleotide repeat (≥4 bp; p < 0.001). In conclusion, the dominant intensity score‐based assessment of HSP110wt IHC can be a simple and useful method for the prognostic stratification of MSI‐H CRCs. It is expected that HSP110wt IHC may be used to identify a subgroup of MSI‐H CRCs with poor prognosis and/or candidates for further treatment, such as immunotherapy using immune checkpoint inhibitors in MSI‐H CRCs.
Aging adult porcine fibroblasts can support nuclear transfer and transcription factor‐mediated reprogramming
Authors: Li Xia , Zhang Pengfei , Jiang Shaoshuai , Ding Biao , Zuo Xiaoyuan , Li Yunsheng , Cao Zubing , Zhang Yunhai 
Published: October 2017

AbstractSomatic cell nuclear transfer (SCNT) and induced pluripotent stem cells (iPSCs) technology are two classical reprogramming methods. Donor cell types can affect the reprogramming results in the above two methods. We here used porcine embryonic fibroblasts (PEFs) and adult porcine ear skin fibroblasts (APEFs) and adipose‐derived stem cells (ADSCs) as donor cells forSCNTand source cells foriPSCs to study theirin vitrodevelopmental capability and colony‐formation efficiency, respectively. ForSCNT, fusion and cleavage rate has no significant difference amongPEFs,ADSCs andAPEFs. The rate and total cell number of blastocysts in theAPEFgroup were significant lower than that inPEFs andADSCs. For transcription factor‐mediated reprogramming, the reprogramming efficiency ofADSCs were significantly higher thanPEFs andAPEFs and there is no significant difference betweenPEFs andAPEFs. Furthermore,PEFs,APEFs andADSCs can be used to generateiPSCs. Fianlly, somatic cloned pigs could still be successfully generated fromAPEFs, suggesting terminally differentiated aging adult somatic cells could be reprogrammed into a totipotent state. Considering the easy availability of animal tissue and the costs of establishing cell lines, aging porcine ear fibroblasts can support nuclear transfer‐mediated and transcription factor‐based reprogramming.