bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of PADUA Score as Predictor of Warm Ischemia Time (WIT) during Laparoscopic Partial Nephrectomy (LPN)
Authors: Ricciardulli Stefano , Ding Qiang , Zhang Xu , Li Hongzhao , Wang Baojun , Yang Guoqiang , Wang Xiyou , Zhang Peng , Ma Xin , Breda Alberto 
Published: November 2016

Objective To evaluate the efficacy of Preoperative Aspects and Dimension Used for an Anatomical (PADUA) classification in the prediction of Warm Ischemia Time (WIT) during Laparoscopic Partial Nephrectomy (LPN). Methods Single centre retrospective study on 402 patients who underwent LPN between January 2011 and October 2013. WIT was correlated with each characteristics of the PADUA classification. Univariate and multivariate analysis were used to evaluated the independent predictive risk factors of WIT >20 minutes. Results The median WIT was 19.8 minutes (IQR 15-25). The PADUA risk groups (High vs Low: OR: 2.804; 95% CI 1.155-6.806; p-value <0.001; Intermediate vs Low: OR 0.971; 95% CI 0.185-5.092 p-value <0.001) and PADUA score as continuous variable (OR: 1.512; 95% CI 1.043-2.194; p-value <0.001) were the best independent risk factors of WIT >20 minutes. Another important factor related with WIT >20 minutes was a CKD stage 3 (p-value: 0.047; OR: 0.528; 95% CI:0.282-0.990). Conclusions This study reveal that tumor’ anatomical aspects may influence the WIT. The use of the nephrometry scoring systems should to be use by the surgeon in the planning of nephron sparing surgery (NSS) and should be considered for its inclusion in international guidelines.
Factors influencing the attitude of equestrians towards sport horse welfare
Authors: Ikinger C , Spiller A , Kayser M 
Published: November 2016

AbstractUntil now, only a limited amount of research has been carried out on addressing attitudes towards sport horse welfare (AHW). In order to contribute to filling this gap, the goals of this study were two-fold: the investigation of the influence of different demographic factors and factors related to equestrianism on the AHW and the demonstration of the applicability of Partial Least Squares Equation Modelling (PLS) in this field of research. An online survey was conducted among 2,947 equestrians. A research model was established based on eleven factors, which were investigated for their potential influence on the AHW and their relationships to each other. This model was analysed by means of PLS which, to the best of our knowledge, has not been used before to investigate human attitudes towards horses (Equus caballus). The results show that the factors with the highest impacts on the AHW were the affection for animals, the attitude towards classically organised equestrianism and the utility orientation. Gender, income, agricultural background, tradition, brand orientation and the importance of breed and pedigree were also found to exert a significant influence on the AHW. In contrast, age and involvement in horse-riding as a hobby were found to have no effect on the AHW. Furthermore, several significant relationships could be identified among the different factors. In conclusion, the present study provides an insight into the factors influencing the complex AHW and demonstrates the applicability of the PLS for research in this field.
Attitudes of beef producers to disbudding and perception of pain in cattle
Authors: Wikman I , Hokkanen A-H , Pastell M , Kauppinen T , Valros A , Hänninen L 
Published: November 2016

AbstractPain is an indicator of welfare status in livestock, and attitudes play a key role in the assessment and treatment of pain in animals. Veterinarians’ and dairy producers’ perceptions of cattle pain are affected by gender, age and work experience. The aim of this paper was to study beef producers’ attitudes regarding disbudding as well as the painfulness of certain cattle diseases. A questionnaire was sent out to 1,000 Finnish beef producers and the response rate was 44%, representing 19% of all Finnish beef producers. Producers graded their attitudes on a five-point Likert scale and perception about pain on an eleven-point numerical scale. Factor analysis was used and four factors were established. These factors described producers’ assessment of disbudding-related pain, their sensitivity to pain in cattle, their willingness to self-medicate disbudded calves and their perceived importance of horns. Factor scores were tested for differences between genders and the use of disbudding on farms with Mann WhitneyU-tests. Kruskal-Wallis tests were used to assess differences among producers’ age, work experience and herd size. Female beef producers assessed animal pain higher than male beef producers. Older and more experienced beef producers showed more positive attitudes towards cattle with horns than younger or less-experienced ones. Older beef producers were more sensitive to cattle pain than younger producers and beef producers with a smaller herd size took disbudding pain more seriously and were more sensitive to cattle pain than the producers with larger herds. Producers who did not use disbudding valued horns more than producers using disbudding.
Land dominates the regional response to CO2 direct radiative forcing
Authors: Shaw Tiffany A. , Voigt Aiko 
Published: November 2016

AbstractIn Atmospheric General Circulation Models (AGCMs) direct radiative forcing (increased CO2 with fixed sea surface temperature) is an imperfect concept because land temperatures are not fixed. Here the response to direct radiative forcing is decomposed into increased CO2 over ocean and land using an AGCM with spatially dependent CO2. The land versus ocean response is mostly linear. Consistent with previous work, ocean direct radiative forcing decreases ocean‐averaged outgoing longwave radiation, precipitation, and tropical circulation intensity; however, it cannot explain the regional response to direct radiative forcing. Increased CO2 over land dominates the regional response via energy input over land, e.g., over deserts where there is no cloud and water vapor masking and a Rossby wave teleconnection. This mechanism operates across a range of climate perturbations, including decreased CO2. Previous AGCM decompositions involving direct radiative forcing and indirect sea surface temperature warming must be reinterpreted to include the importance of increased CO2 over land.
Application of an Integrated Good Lives Approach to Sexual Offending Treatment
Authors: Willis Gwenda M. , Prescott David S. , Yates Pamela M. 
Published: November 2016

Abstract
The Good Lives Model (GLM) is a strengths‐based theory of offender rehabilitation that has been integrated with the Risk–Need–Responsivity principles and the Self‐Regulation Model – Revised. This chapter describes treatment implications of an integrated good lives approach to sexual offending treatment, with a focus on how the GLM augments traditional risk‐focused approaches. Assessment and intervention planning represent the foundations of effective treatment and are described in some detail, followed by an overview of core treatment components. The GLM offers clinicians an inherently motivating and engaging framework for working with individuals who have sexually offended to reduce their risk of future offending, and to assist them to live better, more fulfilling, lives.
Nickel‐Catalyzed Esterification of Aliphatic Amides
Authors: Hie Liana , Baker Emma L. , Anthony Sarah M. , Desrosiers Jean‐Nicolas , Senanayake Chris , Garg Neil K. 
Published: November 2016

AbstractRecent studies have demonstrated that amides can be used in nickel‐catalyzed reactions that lead to cleavage of the amide C−N bond, with formation of a C−C or C−heteroatom bond. However, the general scope of these methodologies has been restricted to amides where the carbonyl is directly attached to an arene or heteroarene. We now report the nickel‐catalyzed esterification of amides derived from aliphatic carboxylic acids. The transformation requires only a slight excess of the alcohol nucleophile and is tolerant of heterocycles, substrates with epimerizable stereocenters, and sterically congested coupling partners. Moreover, a series of amide competition experiments establish selectivity principles that will aid future synthetic design. These studies overcome a critical limitation of current Ni‐catalyzed amide couplings and are expected to further stimulate the use of amides as synthetic building blocks in C−N bond cleavage processes.
Photoredox Activation of SF6 for Fluorination
Authors: McTeague T. Andrew , Jamison Timothy F. 
Published: November 2016

AbstractWe report the first practical use of SF6 as a fluorinating reagent in organic synthesis. Photoredox catalysis enables the in situ conversion of SF6, an inert gas, into an active fluorinating species by using visible light. Under these conditions, deoxyfluorination of allylic alcohols is effected with high chemoselectivity and is tolerant of a wide range of functional groups. Application of the methodology in a continuous‐flow setup achieves comparable yields to those obtained with a batch setup, while providing drastically increased material throughput of valuable allylic fluoride products.
Consumer knowledge, preference, and perceived quality of dried tomato products in Ghana
Authors: Owureku‐Asare Mavis , Ambrose R. P. Kingsly , Oduro Ibok , Tortoe Charles , Saalia Firibu K. 
Published: November 2016

AbstractPostharvest losses (PHL) are incurred in the tomato value chain in Ghana and solar drying of tomato is a promising technology for reducing the loss. However, there are concerns on the usage, functionality and sensory appeal of the dried products to consumers, compounded with the lack of information and research on dried tomato processing in Ghana. A survey was carried out by administering semistructured questionnaires to 395 randomly selected and willing respondents in the Accra Metropolis. Information was obtained on the socioeconomic profile, consumption pattern, knowledge, and acceptance of tomato processing technologies and assessment of quality attributes important to consumers. Most consumers (74%) preferred tomato powder that is conveniently packaged to retain the characteristic intense taste and the flavor using Friedman's rank mean procedure. The study indicated that consumers were more concerned about good manufacturing practices during the production of solar‐dried tomato (48.8%) rather than the quality attributes (8.6%). These findings indicate the need for safe solar drying procedures in order to increase consumer acceptability of solar‐dried tomato products in Ghana.
Outcomes of patients with hepatocellular carcinoma are determined in multidisciplinary team meetings
Authors: Charriere Bérénice , Muscari Fabrice , Maulat Charlotte , Bournet Barbara , Bonnet Delphine , Bureau Christophe , Otal Philippe , Peron Jean‐Marie , Suc Bertrand 
Published: November 2016

Background and ObjectivesTo analyze overall survival (OS) rates for the three curative treatments of hepatocellular carcinoma (HCC) on an intention‐to‐treat (ITT) basis.MethodsCohort study based on data from a multidisciplinary team meeting (MDT) dedicated to HCC. From 2006 to 2013, we included every patient with newly diagnosed HCC, for whom curative treatment (liver transplantation (LT), radiofrequency ablation (RFA), surgical resection (SR)) was decided upon.ResultsWe included 387 consecutive patients. LT was decided in 136 cases, RFA in 131 cases, SR in 120 cases. Sixty‐six percent of patients received the planned treatment. Five‐year OS on an ITT basis were: 35% for the LT‐group, 32% for the RFA‐group, 34% for the SR‐group (P = 0.77). In multivariate analyses, the main negative prognostic factors were not following the MDT decision (HR: 0.39, CI95% [0.27–0.54], P < 0.001), elevated alpha‐fetoprotein level (HR: 0.63, CI95% [0.45–0.87], P = 0.005), being outside the Milan criteria (HR: 0.45, CI95% [0.31–0.65], P < 0.001). When curative treatment was performed, per‐protocol 5‐year OS were 64% for LT, 34% for RFA, 40% for SR.ConclusionOn an ITT basis, OS was similar whatever the type of curative treatment chosen in MDT. Negative prognostic factors were not following the MDT decision, elevated alpha‐fetoprotein, being outside the Milan criteria. J. Surg. Oncol. 2017;115:330–336. © 2016 Wiley Periodicals, Inc.
Kinetic Effects on Self‐Assembly and Function of Protein–Polymer Bioconjugates in Thin Films Prepared by Flow Coating
Authors: Chang Dongsook , Huang Aaron , Olsen Bradley D. 
Published: November 2016

The self‐assembly of nanostructured globular protein arrays in thin films is demonstrated using protein–polymer block copolymers based on a model protein mCherry and the polymer poly(oligoethylene glycol acrylate) (POEGA). Conjugates are flow coated into thin films on a poly(ethylene oxide) grafted Si surface, forming self‐assembled cylindrical nanostructures with POEGA domains selectively segregating to the air–film interface. Long‐range order and preferential arrangement of parallel cylinders templated by selective surfaces are demonstrated by controlling relative humidity. Long‐range order increases with coating speed when the film thicknesses are kept constant, due to reduced nucleation per unit area of drying film. Fluorescence emission spectra of mCherry in films prepared at <25% relative humidity shows a small shift suggesting that proteins are more perturbed at low humidity than high humidity or the solution state.
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Endoplasmic reticulum stress contributes to ferritin molecules‐mediated macrophage migration via P‐selectin glycoprotein ligand‐1
Authors: Wang Chi‐Mei , Chen Yue‐Hwa , Lee Yu‐Chieh , Chang Jung‐Su 
Published: November 2016

ScopeObesity is associated with elevated serum ferritin and increased macrophage activation and infiltration; however, the causal mechanisms underlying this relationship remain undefined.Methods and resultsSerum ferritin and soluble P‐selectin glycoprotein ligand (sPSGL)‐1 level were higher in obese adolescents and patients with moderate nonalcoholic fatty liver disease (NAFLD) compared with controls (all p < 0.05). Multivariate linear regression revealed that serum ferritin was independently associated with sPSGL‐1 (B = 0.249, 95% confidence interval: 0.011–0.487, p = 0.041) after adjustment for covariates. The messenger (m) RNA expression of GRP78/Bip, ferritin, and PSGL‐1 in leukocytes was greater in patients with nonalcoholic fatty liver disease than in controls. An animal study showed that a tunicamycin injection (an endoplasmic reticulum stress inducer) triggered serum sPSGL‐1 and ferritin elevation (all p < 0.01). An in vitro study revealed that serum ferritin and apoferritin induced tumor necrosis factor‐α and sPSGL‐1 secretion (all p < 0.01). A wound healing assay showed that PSGL‐1 blocking inhibited apoferritin‐mediated macrophage migration. GRP78/Bip knockdown by the endotoxin EGF‐SubA completely inhibited apoferritin‐mediated macrophage migration and PSGL‐1 expression at the protein and mRNA levels (all p < 0.05).ConclusionER stress associated mechanisms are required for apoferritin‐/ferritin‐mediated macrophage migration via the PSGL‐1‐dependent pathway.
Individual pharmacokinetic variation leads to underdosing of ciprofloxacin in some cystic fibrosis patients
Authors: Schultz A.N.Ø. , Høiby N. , Nielsen X.C. , Pressler T. , Dalhoff K. , Duno M. , Buchard A. , Johansen H.K. , Wang H. , Dalbøge C.S. 
Published: November 2016

SummaryBackground: Ciprofloxacin (CIP) is frequently used when treating cystic fibrose (CF) patients with intermittent Pseudomonas aeruginosa (P. aeruginosa) lung colonization. However, approximately 20% of the patients progress to chronic infection despite early intervention. The aim of this study, was to investigate the pharmacokinetics of CIP, to evaluate if CYP3A4‐related metabolism is involved and to find the optimal dose needed to eradicate intermittently colonizing bacteria in the lungs of CF patients. Methods An open‐label, prospective pharmacokinetic study was performed. Twenty‐two adult CF‐patients were each given 500 mg CIP orally. One blood sample was taken at t = 0, and the following 12 hr, nine blood samples were collected. The optimal dose and interval was then calculated by Monte Carlo simulation. CYP3A4‐activity was mesured using the Erythromycin Breath Test (ERMBT). Results A 14‐fold variation in AUC for the 500 mg CIP (median 473.5 µg/ml × min), and a 30‐fold variation in Cmax for CIP (median 2 µg/ml) was found. For CYP3A4‐activity the variation was 8‐fold. No correlation was found between the CYP3A4‐activity and CIP‐concentrations. The probability of eradicating intermittent P. aeruginosa colonization in the lungs of CF patients was found to be 57% (3 doses/day), when 500 mg CIP was given. It was calculated to be 89% (2 doses/day) and 94% (3 doses/day), respectivly if 750 mg CIP had been given. Conclusion A large pharmacokinetic difference of CIP in CF patiens was found, not explained by CYP3A4 variation. CIP should be given at 750 mg two or three times daily to adult CF patients with intermittently colonization. Pediatr Pulmonol. 2017;52:319–323. © 2016 Wiley Periodicals, Inc.
Diiron Complexes [Fe2(CO)5(μ‐pdt/Mebdt)(L)] Containing a Chelating Diphosphine Ligand L=(Oxydi‐2,1‐phenylene)bis(diphenylphosphine): Bioinspired [FeFe] Hydrogenase Model Complexes
Authors: Pandey Indresh Kumar , Natarajan Mookan , Hemlata  , Hussain Firasat , Kaur‐Ghumaan Sandeep 
Published: November 2016

AbstractDiiron carbonyl complexes [Fe2(CO)5(μ‐pdt)(κ1‐L)] 1 and [Fe2(CO)5(μ‐Mebdt)(κ1‐L)] 3 were obtained in moderate yields from the parent complexes [Fe2(CO)6(μ‐pdt)] and [Fe2(CO)6(μ‐Mebdt)] and the chelating diphosphine ligand, L=(Oxydi‐2, 1‐phenylene)bis(diphenylphosphine). In addition, complexes [Fe2(CO)5(μ‐pdt)(κ1‐LO)] 2 and [Fe2(CO)5(μ‐Mebdt)(κ1‐LO)] 4 containing oxidized phosphine (P=O) were obtained as side products of the reaction. In all the four complexes only one phosphorus site of the diphosphine ligand was found to coordinate to the metal center. X‐ray crystal structures have been reported for complexes 1, 3 and 4. Complexes 1, 3 and 4 were investigated for electrocatalytic proton reduction in the presence of acetic and trifluoroacetic acid. Complexes 3 and 4 showed higher acid‐induced currents than 1 when investigated with both the acids. The over potentials for the three complexes were however, on the higher side. Moreover, complex [Fe2(CO)5(μ‐Mebdt)(κ1‐LO)] 4 with oxidized phosphine was catalytically more efficienct than [Fe2(CO)5(μ‐Mebdt)(κ1‐L)] 3 without oxidized phosphine.
Mesh Removal and Selective Neurectomy for Persistent Groin Pain Following Lichtenstein Repair
Authors: Zwaans Willem A. R. , Perquin Christel W. , Loos Maarten J. A. , Roumen Rudi M. H. , Scheltinga Marc R. M. 
Published: November 2016

AbstractBackgroundSome patients with persistent inguinodynia following a Lichtenstein hernia repair fail all non‐surgical treatments. Characteristics of mesh‐related pain are not well described whereas a meshectomy is controversial. Aims were to define mesh‐related pain symptoms, to investigate long‐term effects of a meshectomy and to provide recommendations on meshectomy.MethodsConsecutive patients undergoing open meshectomy with/without selective neurectomy for chronic inguinodynia following Lichtenstein repair were analysed including a follow‐up questionnaire. Outcome measures were complications, satisfaction (excellent, good, moderate, poor) and hernia recurrence rate. Recommendations for meshectomy are proposed based on a literature review.ResultsSeventy‐four patients (67 males, median age 56 years) underwent mesh removal (exclusively mesh, 26%; combined with tailored neurectomy, 74%) between June 2006 and March 2015 in a single centre. Complications were intraoperatively recognized small bowel injury (n = 1) and testicular atrophy (n = 2). A 64% excellent/good long‐term result was attained (median 18 months). Success rates of a meshectomy (63%) or combined with a neurectomy (64%) were similar. Five hernia recurrences occurred during follow‐up (7%). A patient with a pure mesh‐related groin pain characteristically reports a ‘foreign body feeling’. Pain intensifies during hip flexion (car driving) and is attenuated following hip extension or supine position. Palpation is painful along the inguinal ligament whereas neuropathic characteristics (hyperpathic skin, trigger points) are lacking.ConclusionsMesh removal either or not combined with tailored neurectomy is beneficial in two of three patients with characteristics of mesh‐related inguinodynia following Lichtenstein hernia repair who are refractory to alternative pain treatments.
Association between cardiometabolic index and erectile dysfunction: A new index for predicting cardiovascular disease
Authors: Dursun Murat , Besiroglu Huseyin , Otunctemur Alper , Ozbek Emin 
Published: November 2016

AbstractOver the past decade, it has been suggested that erectile dysfunction (ED) is an early indicator of cardiovascular disease. In a recent study, a new index, termed as cardiometabolic index (CMI), was defined and measured as the product of triglyceride (TG)/high‐density lipoprotein‐cholesterol (HDL‐C) ratio and waist‐to‐height ratio, which are good predictors of coronary artery disease and main components of metabolic syndrome (MetS). All components of the CMI are also included in MetS criteria. Thus, we decided to evaluate the correlation between CMI, including the criteria of MetS, and ED. A total of 95 men with ED (ED group) and 82 healthy men (control group) were included in the study. Sexual functions were evaluated using the International Index of Erectile Function‐5 items scale. CMI was measured as the product of waist‐to‐height ratio and TG/HDL‐C ratio. Mean CMI level was 2.33 ± 0.11 in the study group and 1.14 ± 0.076 in the control group. CMI levels were significantly higher in the ED group (p < 0.001). Because of the simplicity of measuring waist circumference, height measurement, and TG and HDL levels, CMI is an easily applicable index for evaluating cardiovascular dysfunction. ED is thought to be a precursor sign for vascular disease and a potential marker for atherosclerosis, endothelial dysfunction, and cardiovascular disease. In this context, CMI can be a useful index for the evaluation and calculation of ED risk, which was used for evaluation of cardiometabolic risk.
Association of placental Plasmodium falciparum parasitaemia with maternal and newborn outcomes in the periurban area of Bobo-Dioulasso, Burkina Faso
Authors: CISSE MAMOUDOU , DIALLO A. HAMA , SOMÉ D. ADOLPHE , PODA ARMEL , AWANDARE A. GORDON , GUIGUEMDÉ T. ROBERT 
Published: November 2016

SUMMARYThe prevalence of placental malaria and its impact on maternal and newborn outcomes have been poorly documented in periurban settings of Burkina Faso. Peripheral and placental blood from 320 mothers, and cord blood from their newborns were collected through a cross-sectional study and used to prepare thick and thin blood films. Maternal haemoglobin concentration and birthweight were also measured. The overall malaria parasitaemia prevalence in peripheral, placental and cord blood was of 17·2, 9·1 and 0·9%, respectively.Plasmodium falciparumwas the sole species found in all cases and the mean parasite density in placental blood was 4·5 ± 0·8 parasitesµL−1. Primigravida (aOR: 3·5; 95% CI (1·1–11·2)) and women who did not use a bed net (aOR: 2·6; 95% CI (1·1–6·3)), were at higher odds of placental malaria infection. Women with placental parasitaemia were at increased odds of maternal anaemia (aOR: 3·1; 95% CI (1·3–7·4)). There was no odds difference for LBW between mothers with placental parasitaemia and those without. Placental malaria parasitaemia resulted in a significant mean birthweight reduction of 200 g. Placental malaria infection is higher in primigravida. Use of insecticide-treated bed nets should be therefore emphasized for primigravida during the first antenatal care visit.