bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicenter Phase II Study of Lenalidomide in Relapsed or Recurrent Adult T-Cell Leukemia/Lymphoma: ATLL-002
Authors: Ishida Takashi , Fujiwara Hiroshi , Nosaka Kisato , Taira Naoya , Abe Yasunobu , Imaizumi Yoshitaka , Moriuchi Yukiyoshi , Jo Tatsuro , Ishizawa Kenichi , Tobinai Kensei , Tsukasaki Kunihiro , Ito Shigeki , Yoshimitsu Makoto , Otsuka Maki , Ogura Michinori , Midorikawa Shuichi , Ruiz Wanda , Ohtsu Tomoko 
Published: September 2016

PurposeFew treatment options exist for adult T-cell leukemia/lymphoma (ATL), and the prognosis for this disease is poor. A phase I study of lenalidomide demonstrated preliminary antitumor activity in patients with relapsed ATL. The current phase II study evaluated the efficacy and safety of lenalidomide monotherapy in patients with relapsed or recurrent ATL.Patients and MethodsPatients 20 years of age or older with acute, lymphoma, or unfavorable chronic subtype ATL, who had received one or more prior anti-ATL systemic chemotherapy and achieved stable disease or better on their last anti-ATL therapy with subsequent relapse or recurrence, were eligible. Patients received oral lenalidomide 25 mg/d continuously until disease progression or unacceptable toxicity. The primary end point was overall response rate; secondary end points included safety, tumor control rate (stable disease or better), time to response, duration of response, time to progression, progression-free survival, and overall survival.ResultsObjective responses were noted in 11 of 26 patients (overall response rate, 42%; 95% CI, 23% to 63%), including four complete responses and one unconfirmed complete response. The tumor control rate was 73%. The median time to response and duration of response were 1.9 months and not estimable, respectively, and the median time to progression was 3.8 months. The median progression-free survival and overall survival were 3.8 and 20.3 months, respectively. The most frequent grade ≥ 3 adverse events were neutropenia (65%), leukopenia (38%), lymphopenia (38%), and thrombocytopenia (23%), which were all manageable and reversible.ConclusionLenalidomide demonstrated clinically meaningful antitumor activity and an acceptable toxicity profile in patients with relapsed or recurrent aggressive ATL, hinting at its potential to become a treatment option. Further investigations of lenalidomide in ATL and other mature T-cell neoplasms are warranted.
Cost Effectiveness of the Oncotype DX DCIS Score for Guiding Treatment of Patients With Ductal Carcinoma In Situ
Authors: Raldow Ann C. , Sher David , Chen Aileen B. , Recht Abram , Punglia Rinaa S. 
Published: September 2016

Purpose The Oncotype DX DCIS Score short form (DCIS Score) estimates the risk of an ipsilateral breast event (IBE) in patients with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery without adjuvant radiation therapy (RT). We determined the cost effectiveness of strategies using this test. Materials and Methods We developed a Markov model simulating 10-year outcomes for 60-year-old women eligible for the Eastern Cooperative Oncology Group E5194 study (cohort 1: low/intermediate-grade DCIS, ≤ 2.5 cm; cohort 2: high-grade DCIS, ≤ 1 cm) with each of five strategies: (1) no testing, no RT; (2) no testing, RT only for cohort 2; (3) no RT for low-grade DCIS, test for intermediate- and high-grade DCIS, RT for intermediate- or high-risk scores; (4) test all, RT for intermediate- or high-risk scores; and (5) no testing, RT for all. We used utilities and costs extracted from the literature and Medicare claims to determine incremental cost-effectiveness ratios and examined the number of women needed to irradiate per IBE prevented. Results No strategy using the DCIS Score was cost effective. The most cost-effective strategy (RT for none or RT for all) was sensitive to small differences between the utilities of receiving or not receiving RT and remaining without recurrence. The numbers needed to irradiate per IBE prevented were 10.5, 9.1, 7.5, and 13.1 for strategies 2 to 5, respectively, relative to strategy 1. Conclusion Strategies using the DCIS Score lowered the proportion of women undergoing RT per IBE prevented. However, no strategy incorporating the DCIS Score was cost effective. The cost effectiveness of RT was exquisitely utility sensitive, highlighting the importance of engaging patient preferences in this decision. Physicians should discuss trade-offs associated with omitting or adding adjuvant RT with each patient to maximize quality-of-life outcomes.
Age- and Gender-Specific Risk of Thyroid Cancer in Patients With Familial Adenomatous Polyposis
Authors: Uchino Shinya , Ishikawa Hideki , Miyauchi Akira , Hirokawa Mitsuyoshi , Noguchi Shiro , Ushiama Mineko , Yoshida Teruhiko , Michikura Masahito , Sugano Kokichi , Sakai Toshiyuki 
Published: September 2016

Context:
The cribriform-morula variant of papillary thyroid carcinoma (CMV-PTC) is a rare variant of PTC and is associated with familial adenomatous polyposis (FAP). However, the incidence and the nature of CMV-PTC among FAP patients have not been well characterized.

Objective:
The aim of this study was to determine the incidence and characteristics of thyroid cancer screened by neck ultrasonography for FAP patients.

Design, Patients, and Intervention:
A total of 129 FAP patients were included in this study. Neck ultrasonography was performed using a 12.0-MHz transducer probe. Germline APC gene mutation was examined for by the protein truncation test or DNA sequencing methods.

Results:
Twenty-one patients (16.3%) had solid nodules, and 24 patients (18.6%) had benign cystic nodules. In total, PTC was found in 11 patients (16% of the women and 0% of the men), 8 of which were CMV-PTC and the rest were classical PTC. In 17 female patients with thyroid nodules, CMV-PTC occurred in 8 of 9 patients who were 35 years age or younger but in none of the 8 patients who were older than 35 (P = .0004 by Fisher’s exact test). The APC germline mutations in 8 patients with CMV-PTC were present at the 5′ side of the profuse type of FAP region (codons 1249–1330).

Conclusions:
The prevalence of CMV-PTC in FAP patients was higher than previously reported and this type of tumor was found preferentially in younger (under age 35) female patients with FAP in this cohort.
Exploring Inpatient Hospitalizations and Morbidity in Patients With Adrenal Insufficiency
Authors: Stewart Paul M. , Biller Beverly M. K. , Marelli Claudio , Gunnarsson Candace , Ryan Michael P. , Johannsson Gudmundur 
Published: September 2016

Context:Patients with adrenal insufficiency (AI) (primary AI [PAI], secondary AI due to a pituitary disorder [PIT] and congenital adrenal hyperplasia [CAH]) have reduced life expectancy; however, the underlying explanation remains unknown.Objective:To evaluate characteristics, comorbidities, and hospitalizations in AI patients.Design:Retrospective observational.Setting and Population:Using a United States-based national payer database comprising of more than 108 million members, strict inclusion criteria including diagnostic codes and steroid prescription records were used to identify 10 383 adults with AI; 1014 with PAI, 8818 with PIT, and 551 with CAH. Patients were matched 1:1 to controls, based on age (±5 y), gender, insurance, and region and followed for more than 12 months.Intervention:None.Main Outcome Measures:Demographic variables, comorbidities (diabetes mellitus [DM] types 1 and 2, depression, anxiety, hyperlipidemia, hypertension) and hospitalization incidence.Results:Compared with controls, patients with AI had higher odds of DM, hypertension, hyperlipidaemia, depression, and anxiety, ranging from an odds ratio (OR) of 1.51 for hyperlipidaemia in PAI to 3.85 for DM in CAH. Odds of having DM (OR, 3.85; 95% confidence interval, 2.52–5.90) or anxiety (OR, 2.99; 95% confidence interval, 2.02–4.42) compared with controls were highest in CAH, whereas depression was highest in PAI and PIT (OR, 2.40 and 2.55). ORs of hyperlipidaemia and hypertension (OR, 1.98 and 2.24) were highest in the PIT cohort. Inpatient admissions were more frequent in PAI (4.64:1; P &lt; .0001) and PIT (4.00:1; P &lt; .0001) than controls; infection was the most common cause for admission.Conclusion:Patients with AI carry a significant metabolic and psychiatric burden, with higher risk of comorbidities and hospital admissions than matched controls.
Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication
Authors: Mijderwijk Herjan , Klimek Markus , van Beek Stefan , van Schaik Ron H. N. , Duivenvoorden Hugo J. , Stolker Robert Jan 
Published: September 2016

BACKGROUND:
Lorazepam is used as premedication for its anxiolytic properties. The UGT2B15 genotype is of importance for the metabolism of lorazepam. The clinical effect of genetic polymorphisms in UGT2B15 genotype on the treatment of anxiety levels in same-day surgery patients receiving lorazepam, however, is unknown.

METHODS:
Three hundred ninety-eight same-day surgery patients of mixed sex (from a previous double-blinded randomized controlled trial who were assigned to either lorazepam [n = 198] or placebo [n = 200]) were assessed for the UGT2B15*2 variant allele. Anxiety was measured preoperatively and postoperatively by the State part of the State-Trait Anxiety Inventory. The difference between these 2 measurements served as outcome of the study. Analysis of variance was used to assess the State part of the State-Trait Anxiety Inventory difference for interactions among the following factors: UGT2B15 genotype status, treatment condition (lorazepam or placebo), patient sex, and preoperative anxiety score.

RESULTS:
The anxiety difference was complex in that the interaction of lorazepam and UGT2B15 genotype status also was dependent on the joint effect of patient sex and preoperative anxiety score (F = 7.15, P = .008). Further exploration showed clinical relevant results in patients with high preoperative anxiety scores. Striking was that females with high preoperative anxiety scores and genetically reduced lorazepam glucuronidation (UGT2B15*2 homozygotes) showed more postoperative anxiety reduction than males with the same genotype.

CONCLUSIONS:

UGT2B15 genotype contributes to postoperative anxiety reduction after lorazepam premedication. Future research that focuses on patients with high preoperative anxiety scores could help to gain a deeper understanding in the clinical relevance of the interaction between lorazepam and UGT2B15 genotype on postoperative anxiety levels.
Schema modes in cluster B personality disorders
Authors: Dadashzadeh Hossein , Hekmati Issa , Gholizade Hossein , Abdi Reza 
Published: September 2016

Aim of the studyThe present study aimed to investigate the role of schema modes in the cluster B personality disorders.Subject or material and methodsParticipants comprised of 220 individuals – 38 men and 137 women – selected from psychiatric and psychological clinics in Tabriz, Iran. Among the participants, 153 individuals were diagnosed with cluster B personality (44 with the borderline disorder, 16 with antisocial disorder, 56 with histrionic disorder and 37 with narcissistic personality disorder). Furthermore, 67 participants appeared to be without any personality disorders (PDs). The diagnosis of personality disorders was done by using the Structured Clinical Interview for DSM-IV Axis II disorders (SCID-II). All participants (with or without PDs) were asked to answer the Millon Clinical Multi-axial Inventory-3 (MCMI-III) and the Schema Modes Inventory (SMI).ResultsVulnerable, angry and impulsive child modes are predictors of the borderline personality disorder, and the schema modes of the angry child, self-soother and healthy adult are predictors of antisocial personality disorder. Also, the impulsive and happy child, the attack-bully and healthy adult schema modes predict histrionic personality disorder. Finally, the angry, happy child, self-soother and self-aggrandizer schema modes could predict narcissistic personality disorder (NPD).DiscussionSpecial schema modes have roles in explaining cluster B personality disorders, and yet these disorders may overlap each other with regard to some dimensions, especially in terms of cognitions and beliefs among cluster B personality disorders. It can be interpreted as the lack of specificity in categorical classification systems like DSM.Conclusionsthe conclusion is made about the current and alternative models of personality disorders
Clinical Next Generation Sequencing Outperforms Standard Microbiological Culture for Characterizing Polymicrobial Samples
Authors: Cummings Lisa A , Kurosawa Kyoko , Hoogestraat Daniel R , SenGupta Dhruba J , Candra Febrian , Doyle Michael , Thielges Stephanie , Land Tyler A , Rosenthal Christopher A , Hoffman Noah G , Salipante Stephen J , Cookson Brad T 
Published: September 2016

Abstract

BACKGROUND
Humans suffer from infections caused by single species or more complex polymicrobial communities. Identification of infectious bacteria commonly employs microbiological culture, which depends upon the in vitro propagation and isolation of viable organisms. In contrast, detection of bacterial DNA using next generation sequencing (NGS) allows culture-independent microbial profiling, potentially providing important new insights into the microbiota in clinical specimens.

METHODS
NGS 16S rRNA gene sequencing (NGS16S) was compared with culture using (a) synthetic polymicrobial samples for which the identity and abundance of organisms present were precisely defined and (b) primary clinical specimens.

RESULTS
Complex mixtures of at least 20 organisms were well resolved by NGS16S with excellent reproducibility. In mixed bacterial suspensions (107 total genomes), we observed linear detection of a target organism over a 4-log concentration range (500–3 × 106 genomes). NGS16S analysis more accurately recapitulated the known composition of synthetic samples than standard microbiological culture using nonselective media, which distorted the relative abundance of organisms and frequently failed to identify low-abundance pathogens. However, extended quantitative culture using selective media for each of the component species recovered the expected organisms at the proper abundance, validating NGS16S results. In an analysis of sputa from cystic fibrosis patients, NGS16S identified more clinically relevant pathogens than standard culture.

CONCLUSIONS
Biases in standard, nonselective microbiological culture lead to a distorted characterization of polymicrobial mixtures. NGS16S demonstrates enhanced reproducibility, quantification, and classification accuracy compared with standard culture, providing a more comprehensive, accurate, and culture-free analysis of clinical specimens.
Effects of Fabrication Technique on Tensile Properties of Fiber Reinforced Polymer
Authors: Pham T. M. , Hadi M. N. S. , Youssef J. 
Published: September 2016

Abstract
This study investigated the effects of fabrication technique on the tensile properties of fiber reinforced polymer (FRP) flat coupon tests. A total of 20 FRP flat coupons were prepared by two different techniques, which were tested in tension until failure. The first technique of preparing the FRP coupons was based on the recommendation of ASTM D7565/D7565M-10, named the “Cutting Technique,” while the second technique, named the “Folding Technique,” was proposed by this study. Experimental results from this study indicated that preparing FRP coupons using the Cutting Technique resulted in a reduction in the tensile properties as compared to coupons prepared by the proposed Folding Technique. Most notably, the tensile force per unit width obtained by the FRP flat coupons prepared using the Folding Technique was up to 8 % higher than that obtained by coupons prepared using the Cutting Technique. In addition, the effect of the % bending on the tensile properties was also studied. It was found that the % bending about the thickness plane was greater than that of the % bending about the width plane. Furthermore, the tensile properties of the FRP coupons were not sensitive to its % bending.
Assessing Gaseous Hydrogen Assisted Fatigue Crack Growth Susceptibility of Pipeline Steel Weld Fusion Zones and Heat Affected Zones
Authors: Ronevich J. A. , Somerday B. P. 
Published: September 2016

Abstract
The objective of this work was twofold: (1) measure reliable fatigue crack growth relationships for X65 steel and its girth weld in high-pressure hydrogen gas to enable structural integrity assessments of hydrogen pipelines, and (2) evaluate the hydrogen accelerated fatigue crack growth susceptibility of the weld fusion zone and heat-affected zone relative to the base metal. Fatigue crack growth relationships (da/dN versus ΔK) were measured for girth welded X65 pipeline steel in high pressure hydrogen gas (21 MPa) and in air. Hydrogen assisted fatigue crack growth was observed for the base metal (BM), fusion zone (FZ), and heat-affected zone (HAZ), and was manifested through crack growth rates reaching nearly an order of magnitude acceleration over rates in air. At higher ΔK values, crack growth rates of BM, FZ, and HAZ were coincident; however, at lower ΔK, the fatigue crack growth relationships exhibited some divergence with the fusion zone having the highest crack growth rates. These relative fatigue crack growth rates in the BM, FZ, and HAZ were provisional, however, since both crack closure and residual stress contributed to the crack-tip driving force in specimens extracted from the HAZ. Despite the relatively high applied R-ratio (R = 0.5), crack closure was detected in the heat affected zone tests, in contrast to the absence of crack closure in the base metal tests. Crack closure corrections were performed using the adjusted compliance ratio method and the effect of residual stress on Kmax was determined by the crack-compliance method. Crack-tip driving forces that account for closure and residual stress effects were quantified as a weighted function of ΔK and Kmax (i.e., Knorm), and the resulting da/dN versus Knorm relationships showed that the HAZ exhibited higher hydrogen accelerated fatigue crack growth rates than the BM at lower Knorm values.
La investigación como estrategia pedagógica una apuesta por construir pedagogías críticas en el siglo xxi
Authors: Mejía Jimenéz, Marcos Raúl , Manjarrés María Elena 
Published: September 2016

El texto busca fundar la idea de que llevar la investigación a la esfera educativa y pedagógica va a generar una reelaboración del campo de éstas, así como de los mecanismos prácticos y de acción que las han constituido. En primer lugar se realiza un rápido recorrido para reconocer la manera como se han constituido la educación y la pedagogía en la modernidad capitalista occidental; en él se observan los paradigmas, corrientes, concepciones, enfoques y líneas metodológicas y modelos, como aspectos que vertebran estas búsquedas; luego se muestra la manera como se conformó el pensamiento pedagógico en torno a la investigación, el cual da origen a diversas entradas metodológicas para ser resuelto en el cotidiano de las prácticas de los educadores; por último, se fundamenta una de esas líneas metodológicas, la de la Investigación como Estrategia Pedagógica (IEP), surgida en las construcciones de las pedagogías críticas desarrolladas en las realidades latinoamericanas y en diálogo con los enfoques surgidos y dinamizados en diferentes latitudes mundiales
Editorial
Authors: Gordo Contreras Aurora 
Published: September 2016

El arte es la vida Con el ánimo de crear un espacio de referencia sobre la Investigación y la Educación en Artes y Humanidades, la línea de Investigación, Creación y Pedagogía de la Maestría en Educación, presenta una revisión actualizada de los discursos, imaginarios y prácticas de su campo de estudio dentro delcontexto colombiano y latinoamericano en el número seis de la Revista Praxis & Saber; y no puedo desaprovechar el momento para hablar de cómo inició el proceso investigativo en mí. Fue mi padre quien siempre desde niños nos ayudó a encontrar el sentido de la vida y de las cosas. Todo lo resolvía y lo contestaba con preguntas con el fin de que averiguáramos en muchos campos, incluyendo los del espíritu, los de los sentidos y los del corazón, donde confluían el sueño y la reflexión; siempre vi a mi padre como el maestro que ponía a dialogar el pensamiento con la imaginación.
Note on forgotten topological index of chemical structure in drugs
Authors: Ramane Harishchandra S. , Jummannaver Raju B. 
Published: September 2016

Abstract
The forgotten topological index of a graph G is defined as the sum of the cube of the degrees of its vertices. In the recent paper [6], [W. Gao et al. (2016), Forgotten topological index of chemical structure in drugs, Saudi Pharmaceutical Journal, 24, 258-264], the forgotten topological index of some chemical structures has been obtained. In this note, we correct their result regarding triangular benzenoid. Also, we have given the expression for the forgotten topological index of graphene structure which is more compact than the one was obtained in the paper above.
A legitimidade do Estado Regulador brasileiro: uma análise democrática
Authors: Duarte Júnior Ricardo César Ferreira 
Published: September 2016

O presente trabalho apresenta um estudo sobre a legitimidade da regulação econômica na Constituição Federal de 1988. Busca-se fazer uma análise das normas constitucionais com base na interpretação sistemática dessas e no fenômeno da mutação constitucional (específico de um direito dogmático e autônomo, como o atual) para alcançar a legitimidade das decisões proferidas pelas agências reguladoras. Tem-se que a legitimidade deste processo decisório consiste, em última análise, na própria legitimidade do sistema regulatório econômico. Nesse contexto, verificar-se-á que, não obstante a argumentação de “déficit democrático” nas agências, a legitimidade da regulação econômica é alcançada pela participação popular nos procedimentos normativos em sede desses entes regulatórios.
Globalización, pluralidad sistémica y Derecho Administrativo: Apuntes para un Derecho Administrativo Multidimensional
Authors: Reyna Justo J. 
Published: September 2016

Proponer, en tiempos de globalización y transversalidad del derecho, una línea de análisis para que las Administraciones de distinto orden jurídico puedan actuar, junto a particulares, de modo sincronizado y sinérgico. Actuar de modo rápido y eficaz conforme a un régimen jurídico impuesto por el caso y el derecho en red. El Derecho Administrativo Multidimensional es el objetivo de la propuesta. Lo entiendo como un régimen jurídico complejo, especial y derivado que regula la organización y actuación sincronizada de administraciones públicas de distintas dimensiones jurídicas y de particulares, conectados jurídicamente por portales dimensionales correspondientes a un caso determinado. Es un punto de encuentro de sistemas jurídicos. Sobre las premisas del neoconstitucionalismo se modula, entre otros aspectos, la relación clásica entre los actores jurídicos del derecho administrativo y la ley en sentido amplio.
A legitimidade da ANVISA para a regulação da publicidade de alimentos
Authors: Reis Sérgio L. B. F. 
Published: September 2016

Este artigo analisa a legitimidade da regulação da publicidade de alimentos pelo Estado, mais especificamente pela agência reguladora federal responsável por regular vigilância sanitária, a ANVISA. A importância deste assunto está intimamente relacionado ao direito à informação, um direito do consumidor e do cidadão, assim como uma questão de saúde pública uma vez que os hábitos alimentares da população se alteraram. Infelizmente, as alterações não foram para melhor como pode ser observado pelo crescente número de cidadãos com problemas de saúde e a tendência de aumento dos gastos com saúde pelo Estado. A regulação da publicidade de alimentos tem as características de uma política pública preventiva em um tema de grande relevância.