bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cannulated Intravaginal Injection Technique® (CIVIT); A novel vaginal injection technique
Authors: Leylek Ozgur , Peker Berna Haliloglu , Demircivi Ergul , Peker Hakan 
Published: October 2024

Abstract

Objective
Non surgical procedures such as; fillers, PRP and derivates, energy based devices, adipose derivated mesenchimal stem cell treatments are begun to use in women genital area for functional and aesthetic goals as well. After the genital injectable HA was produced, patients were able to benefit from the applications more effectively and it was begun to use in the vagina more common. In our study, we aimed to demonstrate a new intravaginal injection technique, Cannulated Intravaginal Injection Technique® (CIVIT) that we can perform vaginal injection more homogenously and less traumatic and more effectively to the entire vaginal mucosa.
Materials and methods
Retrospectively the data of 43 patients who underwent intravaginal injection of HA manufactured for genital use in private Female Health Clinic were analysed. 21 of 43 were injected by random needling and 23 were injected with CIVIT® and they were all have genitourinary syndrome symptoms (GUS), vaginal health index below 15 and compared for female sexual function index and visual analog scala for GUS before and after the procedures.
Results
It was observed that all postinjection values except for FSFI arousal (p = 0.539), were statistically significantly higher in the CIVIT group (P = 0.001). Postinjection dryness, dyspareunia and discomfort values decreased significantly in the CIVIT® group compared to the Random Needling group.
Conclusion
Our new technique, CIVIT, and random injection, which is a frequently used technique, are two effective techniques for vaginal rejuvenation. However, CIVIT is significantly more effective than the random technique in improving genitourinary symptoms, vaginal health index and sexual function.
Nomogram Predicts In-Hospital Mortality in Patients with Emergency Gastrointestinal Bleeding: A Multicenter Retrospective Study
Authors: Li Ying , Wu Mengmeng , Ouyang Lanxin , Jiang Wei , Liu Di 
Published: October 2024

Abstract

Background
Gastrointestinal bleeding (GIB) is a frequent issue encountered in emergency departments, associated with significant rates of incidence and mortality. This study aims to create and validate a reliable nomogram to predict the risk of in-hospital mortality in patients experiencing emergency GIB. Additionally, it seeks to identify the risk factors that influence mortality and to equip the emergency clinical team with a precise predictive tool.
Methods
This study utilized a retrospective cohort design to analyze data from patients with GIB who presented to the emergency departments and were subsequently admitted at three branches of Wuhan Central Hospital: Nanjing Road, Houhu, and Yangchunhu, from January to December 2023. Patient information was collected through the hospital's information system. The LASSO regression method was employed to identify key variables for prediction, and a nomogram was constructed using multivariate logistic regression. The model's ability to discriminate between outcomes was assessed by calculating the area under the curve (AUC). Furthermore, calibration analysis and decision curve analysis (DCA) were performed to evaluate the model's performance.
Results
A total of 847 patients were included, with 75 (8.85%) dying during hospitalization. In-hospital mortality was more common among elderly patients (median age 73 years vs. 65.5 years for survivors, P < 0.001). Deceased patients had lower systolic and diastolic blood pressures, higher heart rates, and higher shock indices upon emergency admission (P < 0.001). They were more likely to arrive by ambulance (P < 0.001) and classified as ESI Level 1 (P < 0.001). Additionally, they had a higher incidence of malignant tumors (P < 0.001), underwent fewer surgeries (P = 0.003), and received fewer hemostasis procedures (P < 0.001). Their total hospitalization costs were also higher (P < 0.001). Logistic regression analysis identified Ambulance ED, Shock Index > 1, ICU admission, malignancy, and hemostatic procedures as independent risk factors for GIB. ROC curve analysis showed an AUC of 0.862 (95% CI: 0.786–0.939) for the training cohort and 0.846 (95% CI: 0.787–0.904) for the validation cohort.
Conclusion
The developed nomogram model effectively predicts in-hospital mortality risk among emergency GIB patients, demonstrating good classification performance and clinical potential. It is recommended that this model be integrated into clinical information systems to support decision-making and optimize patient management.
Evaluation and optimization strategy for heat exposure space based on behavioral characteristics of crowd activity: A case study of the central Beijing
Authors: Yang Xin , Chen Yue , Wang Zhihao , Ma Xin 
Published: October 2024

Abstract

With the increase of urbanization and global warming in recent years, extreme heat wave events have occurred frequently, and heat waves have caused significant impact on human health and even social development, and heat exposure has become an important environmental cause of human morbidity and mortality. From a human perspective, this paper studies the spatial and temporal characteristics of street heat exposure space and the spatial and temporal differences of crowd activities in central urban areas of Beijing with the help of ArcGIS platform spatial analysis. Combining the spatial distribution of urban street heat exposure with crowd activities, the risk assessment of street heat exposure space during high temperature period is carried out to determine the distribution of high-risk grades. This paper identifies street functions by combining POI data, and divides crowd activities into "necessary activities" and "spontaneous activities" according to street types. Combined with the conclusion on the spatial distribution of dangerous heat, this paper aims to target the spatial environment characteristics of high-risk heat exposure from a humanistic perspective. This paper proposes optimization strategies for the mitigation and reconstruction of dangerous heat space of different population behavior types from three aspects: environmental construction, behavioral activities and physical and mental needs.
The characteristics of surgical site infection with class I incision in Neurosurgery
Authors: Li Yifei , Gao Ling , Fan Shanhong 
Published: October 2024

Abstract

Objective: Surgical site infections (SSIs) were recognized to be the most common complication of neurological surgery, with substantial life quality threats to patients and additional cost burdens to healthcare facilities. This study sought to expound the infection characteristics of class I incision and provide clinical indication for the prevention and treatment of SSIs.
Methods: A 2-year retrospective analysis was conducted according to patients who performed neurological surgery with class I incision in a tertiary comprehensive hospital in Shaanxi Province, China. Case mix index (CMI)-adjusted and national nosocomial infection surveillance (NNIS) risk index-adjusted SSI rate were utilized for analytical standardization. The SSIs were specifically analyzed according to various departments, surgeons, and surgical classifications.
Findings: 6046 surgical cases were finally included in our study. The majority of the American Society of Aneshesiologists (ASA) score and NNIS risk index of surgeries were allocated in level 2 and score 1. Our study found 121 SSI cases, with the crude infection rate of 2.00%. 95.04% were organ/space infection. The most of the infection were found in the surgeries with score 1 (68.60%) of the NNIS risk index. The main surgical classification was resection of space occupying lesions (61.96%). The highest crude and NNIS risk index adjusted infection were individually found in hybrid operation (11.67%) and endoscopy-assisted resection of space occupying lesions (13.33%). 21 of 54 surgeons were found to have SSIs. We found the main pathogenic bacteria was Staphylococcus epidermidis ( 22.81%), and the commonly prophylactic used antibiotics was Cefazolin (51.95%) .
Conclusion: Our study found the main infection was among surgeries with score 1 of NNIS risk index and the surgical classification of endoscopy-assisted resection of space occupying lesions. We indicated specific attention should be paid to the surgeon and surgical classification with highest infection rate to control and prevent SSIs.
Association between Red blood cell distribution width and encephalitis based on the Pediatric Intensive Care Unit database: A Cross-sectional Study
Authors: He weichao , Yang Qilin , zhang Xujie , wang qian , Liu xiaojuan , tong shanshan 
Published: October 2024

Abstract

Background We aimed to explore the association between RDW and encephalitis in Chinese children on Pediatric Intensive Care Unit (PICU) database.
Methods In a cross-sectional study, we analyzed a China-based PIC database spanning from 2010 to 2018. Children admitted to the PIC with encephalitis were included as participants to investigate the correlation between RDW and encephalitis. Additionally, multifactorial logistic regression, restricted cubic spline analysis models and stratified analyses were utilized to evaluate this relationship.
Results A total of 10185 participants were enrolled, among whom the encephalitis prevalence was 1.7% (173/10185). Multivariate regression models revealed that encephalitis in Chinese children was significantly decreased by 18% with 1% increase in RDW after adjusting for all covariates. (Adjusted OR =0.82, 95% CI: 0.73~0.92). When the RDW was analyzed using quartiles, The adjusted OR (95% CI) of encephalitis for participants in the highest RDW Q4 (≥15.9%) were 0.44 (0.23~0.85), respectively. Compared with individuals with lower RDW Q1 (≤13%) (P for trend = 0.011). The association between RDW and childhood encephalitis was stable in the different subgroups ( P for interaction＞0.05). Interaction analysis revealed no interactive role in the association between RDW and encephalitis of the childhood.
Conclusions Our study indicated that RDW was negatively associated with encephalitis in Chinese children. Furthermulticenter prospective studies are needed to validate our findings.
Comparative Effectiveness of Focused Shockwave Therapy and Radial Wave Therapy for Erectile Dysfunction: A Two Centre Prospective Cohort Study
Authors: Bayar Goksel , Ofluoglu Yilmaz , Yildirim Caglar , Basmaci Ismail , Yavuz Abdulmecit 
Published: October 2024

Abstract

Background
Focused shockwave therapy (fSWT) has now taken its place in the algorithm for the treatment of vascular erectile dysfunction (ED) in current guidelines. Radial wave therapy (rWT) has started to be applied with the same indication in recent years and positive results have been reported.
Objective
To compare the long-term effectiveness of focused shockwave therapy fSWT and radial wave therapy rWT in ED.
Methods
A two-center study enrolled 200 patients aged 40 to 70 years with ED complaints. Patients were non-randomly allocated to either fSWT or rWT groups based on the clinic they visited. Pre- and post-treatment International Index of Erectile Function (IIEF) scores were compared, minimal clinically important differences (MCIDs) were calculated and Sexual Encounter Profile-2 (SEP-2) was recorded.
Results
After 3 months, the mean IIEF score for patients in the fSWT group was significantly higher compared to the baseline (13 ± 2.9 vs. 20.4 ± 4.7, p < 0.001), and the same trend was observed at 1 year (13 ± 2.9 vs. 18.1 ± 4.9, p < 0.001). Similarly, in the rWT group, the mean IIEF score was significantly higher at 3 months (13.1 ± 3 vs. 22.8 ± 4.6, p < 0.001) and 1 year (13.1 ± 3 vs. 19.4 ± 4.9, p < 0.001) compared to the baseline. However, there was no significant difference in the mean IIEF score changes between the two groups at both 3 months and 1 year. The proportion of patients giving a positive response to the SEP-2 question was 81% at 3 months and 63.2% at 1 year in the fSWT group, and 88.9% at 3 months and 71.6% at 1 year in the rWT group, with no significant difference between the groups.
Conclusions
Both fSWT and rWT are effective treatments for vascular-related ED, showing comparable efficacy in improving IIEF scores. The potential for periodic applications and longer-term effects warrants further investigation through extended follow-up studies.
The Gut Microbiota Genus Blautia is Associated with Skeletal Muscle Mass Reduction in Community-Dwelling Older Japanese Adults: The Wakayama Study
Authors: Sakaguchi Masato , Miyai Nobuyuki , Zhang Yan , Sakamoto Yukiko , Terada Kazufumi , Utsumi Miyoko , Takeshita Tatsuya , Arita Mikio 
Published: October 2024

Abstract

Purpose: This cross-sectional study examined the gut microbiota species associated with skeletal muscle mass reduction in a community-based sample of older Japanese adults.
Methods: The study included 744 participants aged 65–89 years (mean age, 73 years) with no history of treatment for colorectal, chronic kidney, or liver diseases. Bioelectrical impedance analysis was performed to estimate the appendicular skeletal muscle mass (ASM) of each participant. The gut microbiota composition was assessed using next-generation sequencing targeting the V3-V4 regions of the prokaryotic 16S rRNA genes. A self-administered questionnaire was used to evaluate daily living habits, including food intake associated with maintaining the gut microbiota.
Results: Among the participants, those with reduced muscle mass (defined as an ASM index of less than 4.4 kg/m² for men and 3.7 kg/m² for women) had significantly higher levels of the genus Blautia when compared with those with normal muscle mass (P=0.009). Logistic regression analysis revealed that the association between the genus Blautia and skeletal muscle mass remained significant even after adjusting for multiple confounding factors (P=0.012). Additionally, an increase in the genus Blautia was positively associated with excessive alcohol consumption (≥ 20 g/day, β=0.125, P=0.002) and negatively associated with regular yogurt intake (≥ 1 time/week, β=-0.101, P=0.010), independent of other lifestyle and dietary factors.
Conclusion: Elevated levels of the genus Blautia were associated with reduced skeletal muscle mass in older Japanese adults, suggesting that improving the gut microbiota may be a potential approach to preserving muscle mass among this population.
Pterygomandibular raphe invasion as a prognostic factor in squamous cell carcinoma of the buccal mucosa
Authors: Yoshida Ryoji , Lin Riu , Yamana Keisuke , Obayashi Takeshi , Takeshita Hisashi , Kawahara Kenta , Hirayama Masatoshi , Takahashi Nozomu , Hirosue Akiyuki , Nakayama Hideki 
Published: October 2024

Abstract

This retrospective study assessed the prognostic significance of pterygomandibular raphe (PMR) invasion in resectable squamous cell carcinoma of the buccal mucosa (SCCBM). We included 82 patients with SCCBM who underwent radical resection at Kumamoto University Hospital between 2000 and 2017. Patients were categorized into three groups based on PMR invasion patterns: noncontact, contact, and invasion. The relationship between PMR invasion and clinicopathological characteristics was analyzed using Fisher’s exact test. The Kaplan–Meier method, log-rank test, and Cox regression model were employed for survival analysis. Results indicated that contact or invasion into the PMR was significantly associated with advanced clinical T and N stages, clinical stage, endophytic growth pattern, high-grade invasion pattern, poor tumor differentiation, extranodal extension, and distant metastasis. Patients with PMR invasion experienced a significantly higher proportion of recurrences in the buccal, subcutaneous, mandibular, and masticatory spaces. Univariate analysis indicated that PMR invasion by contact or invasion type SCCBM was a predictor for worse local control rate, disease-free survival, and overall survival, while multivariate analysis revealed that it was an independent worse prognostic factor for overall survival. Thus, PMR invasion is a key prognostic factor in resectable SCCBM.
Integrating Radiomics Features and CT Semantic Characteristics for Predicting Visceral Pleural Invasion in clinical stage Ia peripheral Lung Adenocarcinoma
Authors: Zhao Yunqing , Ye Zhaoxiang , yan Qingna , sun Haoran , Zhao Fengnian 
Published: October 2024

Abstract

Objectives
The aim of this study was to non-invasively predict the visceral pleural invasion (VPI) of peripheral lung adenocarcinoma (LA) highly associated with pleura of clinical stage Ia based on preoperative chest computed tomography (CT) scanning.
Methods
A total of 537 patients diagnosed with clinical stage Ia LA underwent resection and were stratified into training and external validation cohorts at a ratio of 7:3. Radiomics features were extracted using PyRadiomics software following tumor lesion segmentation and were subsequently filtered through spearman correlation analysis, minimum redundancy maximum relevance, and least absolute shrinkage and selection operator regression analysis. Univariate and multivariable logistic regression analyses were conducted to identify independent predictors. A predictive model was established with visual nomogram and external validation, and evaluated in terms of area under the receiver operating characteristic curve (AUC).
Results
The independent predictors of VPI were identified: pleural attachment (p < 0.001), pleural contact angle (p = 0.018) and Rad-score (p < 0.001). The combined model showed good calibration with an AUC of 0.822 (95% confidence intervals (CI): 0.785, 0.869), compared with 0.719 (95% CI: 0.677, 0.760; DeLong’s test p < 0.001) when radiomics was used alone. For validation group, the accuracy of combined prediction model was reasonable with an AUC of 0.785 (95% CI: 0.742, 0.821).
Conclusion
Our predictive model, which integrated radiomics features of primary tumors and peritumoral CT semantic characteristics, offers a non-invasive method for evaluating VPI in patients with clinical stage Ia LA. Additionally, it provides prognostic information and supports surgeons in making more personalized treatment decisions.
Associations Between Maternal Abortion History and Neonatal Outcome among Very Preterm Infants：a multicenter cohort study
Authors: Yang Min , Yang Jie , Wang Dianna , Dai Jiale , Fan Xiaobo , Cao Yun , Zhou Wenhao , Lee Shoo K , Wang Jimei , Hu Liyuan 
Published: October 2024

Abstract

Background
It is unclear whether there is an association between maternal abortion history and neonatal outcomes of singleton very preterm infants (VPIs). We assess the association between maternal abortion history and neonatal outcome of VPIs in China.
Methods
All first parity singleton VPIs born at < 32 weeks gestational age (GA) who were admitted to neonatal intensive care units (NICU) participating in the Chinese Neonatal Network (CHNN) from 2019 to 2021 were included in the study. Multivariable logistic regression models were constructed to compare neonatal outcomes among infants with different maternal abortion histories after adjusting for confounders.
Results
A total of 7256 VPIs were included in this analysis. Overall, 3133 (43.2%) infants had positive maternal abortion history. The incidence of mortality or any major morbidity including respiratory distress syndrome (RDS), patent ductus arteriosus (PDA), intraventricular haemorrhage (IVH), IVH stage 3 or 4, moderate or severe bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), ROP stage 3, 4, or 5 tended to increase significantly with increasing number of maternal abortion histories from non-abortion group to ≥2 abortions group. Multivariable analysis showed that maternal abortion history was significantly associated with higher risks of mortality or any major morbidity (adjusted odds ratio [aOR] 1.15, 95% confidence interval [CI] 1.03–1.29), RDS (aOR 1.22, 95%CI 1.08–1.38), IVH (aOR 1.17, 95% CI 1.05–1.31), and IVH stage 3 or 4 (aOR 1.27, 95% CI 1.01–1.59). Risk increased with the number of abortions. VPIs of mothers with two or more abortions had the highest risk of mortality or any major morbidity (aOR 1.18, 95% CI 1.02–1.36), RDS (aOR 1.35, 95% CI 1.18–1.56), IVH (aOR 1.23, 95% CI 1.07–1.43) and moderate or severe BPD (aOR 1.17, 95% CI 1.01–1.36), compared to the non-abortion group.
Conclusions
In China, VPIs born to mothers with previous abortion history may have a greater risk of adverse outcomes. Based on the potential impact of maternal abortion history on newborns, it is necessary to provide additional information on related risks during antenatal counseling for these mothers.
Elevation of lipoprotein(a) and PCSK9 serum plasma concentration among patients with angiogram-proven premature coronary artery disease in an Asian Cohort
Authors: Zulkapli Rahayu , Nawawi Hapizah , Muid Suhaila Abd , Wang Seok Mui , Ra Ahmad Bakhtiar Md , Ibrahim Khairul Shafiq 
Published: October 2024

Abstract

Coronary artery disease (CAD) has been associated with elevated Lp(a) levels, yet the underlying mechanism by which Lp(a) mediates atherogenesis and inflammation is still incompletely understood. Proprotein convertase subtilisin/kexin type 9 (PCSK9) known to be during the inflammatory process, thus a potential relationship between Lp(a) and PCSK9 could be established. This study aimed to investigate the correlation and association between Lp (a) and PCSK9 in the angioproven-premature CAD (AP-pCAD) subjects with and without FH. Patients were recruited from Cardiology and Specialist Lipid Clinics were grouped into + pCAD + FH (n = 70), +pCAD -FH (n = 65), and -CAD-FH (G3; n = 69). FH was clinically diagnosed using Dutch Lipid Clinic Network Criteria. Lp(a) and PCSK9 levels were measured using an automated chemistry analyser and ELISA, respectively. Both were higher in + pCAD + FH [27.2 (13.2–72.2), 431.4 (178.0-1008.0)] and + pCAD -FH [34.7 (12.7-100.9), 471.4 (333.1–1188.0] compared to G3 [7.5 (7.0-14.7), 389.7 (147.1-566.2)]. In conclusion, Lp(a) and PCSK9 levels were significantly higher in pCAD compared to G3-normal control (NC) group, regardless the FH clinical diagnosis. A significant correlation was found in all pCAD and NC groups. We suggested that PCSK9 concentration is correlated with Lp(a) levels in pCAD and NC groups, indicating its potential of becoming a CAD predictor.
Exploring the Mechanism of Macleaya cordata (Willd) R. Br. Against Breast Cancer by Network Pharmacology and Molecular Docking
Authors: Zhang Lei , Huang Jing , Peng Yulong , Yin Su , Cao Yang , Nan Kai 
Published: October 2024

Abstract

Macleaya cordata (Willd) R. Br. (M. cordata) has widely reported antitumor activity, while the underlying mechanism of M. cordata anti-breast cancer (BC) still remains unclear. The compounds of M. cordata were collected from previous researches and screened by drug-likeness rules to identify bioactive compounds. The targets were obtained from MalaCards, Online Mendelian Inheritance in Man, and SwissTargetPrediction database, then overlapped to get intersections as potential anti-BC targets of M. cordata. After topological analysis of the protein-protein interaction network, the correlation analysis of gene expression and patient pathological stage and survival, respectively, was performed, and 4 pivotal targets were obtained. Four bioactive compounds of M. cordata (6-cyanodihydrogensanguinarine, Corysamine, Oxychelirubine, and Berberrubine) had strong binding efficiency with the 4 pivotal genes after molecular docking analysis. The current study demonstrated that M. cordata acts against BC through multiple targets and pathways that may guide further studies on M. cordata anti-BC effects.