bluuebunny/crossref_metadata_2025_split huggingface dataset:
NINJ1 is activated by calcium-driven plasma membrane lipid scrambling during lytic cell death
Authors: Borges Jazlyn P. , Wang Yongqian , David Liron , Volchuk Allen , Martins Brunna , Cai Ruiqi , Wu Hao , Freeman Spencer A. , Goldenberg Neil M. , Salter Michael W. , Steinberg Benjamin E. 
Published: October 2024

AbstractNINJ1 is the terminal executioner of cellular rupture in multiple lytic cell death pathways through its clustering in the plasma membrane. Its activation trigger, however, remains unknown. We found that NINJ1-mediated plasma membrane rupture depends on calcium influx into the cell, which suffices to induce NINJ1-mediated rupture. Using genetic and pharmacologic approaches in macrophages, we show calcium drives membrane rupture through phospholipid scrambling by the calcium-activated scramblase TMEM16F. We next tested whether this calcium-activated NINJ1 mechanism is the elusive pathway by which extracellular ATP stimulates cellular rupture. We show that ATP-stimulation of P2X7R induces NINJ1-mediated cell lysis via calcium influx and TMEM16F lipid scrambling, independently of inflammasomes, pannexins and gasdermin D. Our work reveals the mechanism of NINJ1 activation and solves the long-standing mystery of ATP-induced cytolysis.SummaryElevated cytosolic calcium drives NINJ1-mediated cellular rupture during lytic cell death through plasma membrane lipid scrambling.
XPRS: A Tool for Interpretable and Explainable Polygenic Risk Score
Authors: Kim Na Yeon , Lee Seunggeun 
Published: October 2024

AbstractThe polygenic risk score (PRS) is an important method for assessing genetic susceptibility to diseases; however, its clinical utility is limited by a lack of interpretability tools. To address this problem, we introduce eXplainable PRS (XPRS), an interpretation and visualization tool that decomposes PRSs into genes/regions and single nucleotide polymorphism (SNP) contribution scores via Shapley additive explanations (SHAPs), which provide insights into specific genes and SNPs that significantly contribute to the PRS of an individual. This software features a multilevel visualization approach, including Manhattan plots, LocusZoom-like plots and tables at the population and individual levels, to highlight important genes and SNPs. By implementing with a user-friendly web interface, XPRS allows for straightforward data input and interpretation. By bridging the gap between complex genetic data and actionable clinical insights, XPRS can improve communication between clinicians and patients.
Cold Molecular Ions via Autoionization below the Dissociation Limit
Authors: Schaller Sascha , Seifert Johannes , Valtolina Giacomo , Fielicke André , Sartakov Boris G. , Meijer Gerard 
Published: October 2024

Several diatomic transition metal oxides, rare-earth metal oxides, and fluorides have the unusual property that their bond dissociation energy is larger than their ionization energy. In these molecules, bound levels above the ionization energy can be populated via strong, resonant transitions from the ground state. The only relevant decay channel of these levels is autoionization; predissociation is energetically not possible and radiative decay is many orders of magnitude slower. Starting from translationally cold neutral molecules, translationally cold molecular ions can thus be produced with very high efficiency. By populating bound levels just above the ionization energy, internally cold molecular ions, exclusively occupying the lowest rotational level, are produced. This is experimentally shown here for the dysprosium monoxide molecule DyO, for which the lowest bond dissociation energy is determined to be 0.0831(6) eV above the ionization energy.

Published by the American Physical Society
2024
“Filling the void”: the diversified grassroots disaster narratives of the 2023 riverine flood in Z City, China
Authors: Xu Peiyang , Zhan Chengyu , Xu Mingjing 
Published: October 2024

PurposeDisaster narratives constitute a crucial and unique element in disaster understanding, recovery and communication. Along with facing various severe disasters, China’s dominant official disaster narratives have played an indispensable role in promoting post-disaster social solidarity. However, the consequences of “weak” official disaster narratives remain unknown.Design/methodology/approachIn 2023, during a riverine flood in northern China’s Z City, diversified grassroots disaster narratives emerged, “filling the void” when the official narratives were comparatively “weak”. This paper uses this riverine flood in Z City as an uncommon case to analyze the official-grassroots disaster narrative interaction. During fieldwork, first-hand and second-hand data from in-depth interviews, on-site visits and public information were collected.FindingsBased on fieldwork, this paper first introduced the “weak” official disaster narratives in Z City. Second, this paper organized and classified these grassroots disaster narratives into three interconnected stages: the flood’s causes, government and social responses, and recovery. In “filling the void,” “sacrifice” and “betrayed” sensemaking are detected and functions of these diversified grassroots disaster narratives become clear.Originality/valueOfficial and grassroots disaster narratives are not simply competing, but complementary. As a unique soft lens to interpret disasters, this paper further discussed grassroots disaster narratives’ underlying connotations and potential impacts on social resilience building. Also, this paper provides insights into the disaster narrative dynamics, especially in China’s political and cultural context.
Holistic maintenance management for higher learning institution buildings in Tanzania
Authors: Gwimile Teobard Alphonce 
Published: October 2024

PurposeThere have been claims of inadequate maintenance practice in Tanzania’s higher learning institutions (HLIs), primarily due to the traditional conventional approach where maintenance is only addressed during the usage stage. This study aimed to investigate whether universities and colleges are adopting a holistic approach to maintenance, where it is considered from the inception stage.Design/methodology/approachStructured questionnaires and semi-structured interviews were employed to gather quantitative and qualitative data, respectively. Through purposive sampling, 11 estate managers were selected, with eight of them responding to questionnaires. A comprehensive literature review was also conducted. Quantitative data were analyzed using the Statistical Package for Social Sciences (IBM SPSSTM) Version 20.0, while qualitative data were examined using Nvivo 12 Plus and in-depth analysis.FindingsThe study revealed that, maintenance in HLIs is only marginally considered in a holistic manner. In cases where it is “considered,” this is often by default rather than by design. This has led to maintenance challenges, such as the accelerated deterioration of components, the incompatibility of new maintenance materials with the old ones and difficulties in adapting spaces to meet emerging user requirements. The most frequently occurring words in the word cloud, “considered” and “maintenance”, underscore the necessity of adopting a holistic approach to maintenance management.Research limitations/implicationsThe study was confined to HLIs in the Dar es Salaam region.Practical implicationsThe findings from this study offer valuable insights for maintenance experts implementing holistic approaches in Tanzanian universities and colleges. Top management should focus on proper planning (including maintenance plans and budgets) and decision-making regarding maintenance management. Additionally, the Government of Tanzania may consider implementing policies requiring designing teams to adopt a holistic approach to maintenance before approving building permits.Originality/valueTo the best of the authors’ knowledge, this is the first study to examine whether universities and colleges consider maintenance from a holistic perspective.
Understanding complex casual leisure information needs: an analysis of search requests for books, games, movies and music
Authors: Bogers Toine , Gäde Maria , Koolen Marijn , Petras Vivien , Skov Mette 
Published: October 2024

PurposeIn this paper, we introduce the CRISPS (CRoss-domaIn relevance aSPects Scheme) coding scheme for complex information needs in the four leisure domains of books, games, movies and music. It categorizes the relevance aspects people consider when searching for these resources. The coding scheme and findings help search engines to better support complex information needs, both by prioritizing which aspects are easier to classify automatically and by determining which information sources should be considered.Design/methodology/approachA cross-domain classification scheme for relevance aspects and information needs in casual leisure domains (CRISPS) is developed and applied. The paper provides the documentation of the scheme development and annotation process as well as a detailed, large-scale analysis of 2000 requests (500 per domain) and relevance aspects for four domains as expressed in complex search requests in everyday life information seeking posted to online forums.FindingsWe identify and discuss relevance aspect frequencies, information need types and the described search process of the requests. Furthermore, the coding scheme development and the annotation process are documented and reflected on.Originality/valueThis is the first categorization and analysis of complex information needs in these four leisure domains combined. The coding scheme and findings can be used to develop new types of search interfaces that incorporate the kinds of relevance aspects identified in the scheme, allowing to express complex needs in the form of structured queries.
Do board characteristics affect financial sustainability? The COVID-19 pandemic experience
Authors: Sajwani Burair , Al-Shboul Mohammad , Maghyereh Aktham 
Published: October 2024

Purpose
This study aims to analyze the board characteristics–financial sustainability relationship in the largest US nonfinancial listed firms and the impact of the COVID-19 pandemic on this relationship.

Design/methodology/approach
Board characteristics such as attendance, cultural diversity, size, experience and gender diversity were assessed in relation to financial sustainability through various regression models, using 2007–2023 panel data of nonfinancial S&P 500 firms.

Findings
The examined board characteristics are positively associated with financial sustainability. The COVID-19 pandemic accentuated this association, which emphasizes the importance of effective board oversight during crises.

Practical implications
The findings provide guidance to shareholders, managers and regulators seeking to enhance corporate governance and financial sustainability. The adoption of effective supervisory and monitoring mechanisms can improve financial sustainability and reporting practices.

Social implications
Enhanced financial sustainability practices can lead to a more stable and secure financial future for companies, thus benefiting employees, shareholders and communities. This study offers insights for promoting the overall social and economic well-being of the US market.

Originality/value
This study enhances knowledge on how board characteristics influence financial sustainability, particularly during crises such as the COVID-19 pandemic. It provides insights into safeguarding stakeholder interests and improving financial sustainability in the US market.
Change in organizational fields: the role of peripheral actors within the Colombian coffee industry (1960–2020)
Authors: Yepes-Lugo Cristian Armando , Ojeda-Pérez Robert , Vera-Acevedo Luz Dinora 
Published: October 2024

Purpose
This paper aims to evaluate the evolution of the organizational field in the Colombian coffee industry between 1960 and 2020 and explain how peripheral actors influenced institutional change.

Design/methodology/approach
The methods analyze historical processes from a hermeneutical and interpretative perspective. The authors used data collection techniques through interviews, archive data, publications and media reports, embracing an interdisciplinary and qualitative documentary approach. This approach helps the authors unravel the temporal dimensions of the historical discourse related to coffee and the involvement of various actors within organizational structures.

Findings
The authors found that, unlike the literature regarding the change in organizational fields, recently, within the coffee sector in Colombia, the institutional work of peripheral actors (small producers, local associative groups and coffee women, among others) is changing the field as follows: (1) women are changing traditional behaviors moving from hierarchical family structures and lack of gender awareness, to empowered, horizontal and sustained relationships, (2) indigenous people include rituals and other traditional practices in coffee production and (3) ex-guerrilla members are helping to strengthen the peace process implementation in Colombia through coffee production.

Research limitations/implications
The authors did not conduct statistical or computational analysis to simulate the emergence of new organizational forms. Instead, the authors attempted to elucidate narratives and discourses that reflect the tensions between central and peripheral actors from a historical perspective.

Practical implications
This study seeks to help leaders and managers overcome processes or organizational change in which peripheral actors are crucial. From that perspective, allocating resources and capabilities can become more effective.

Originality/value
This paper offers a new perspective of change within organizational fields from the roles of peripheral actors, which are fundamental in change processes within organizational fields, especially in the global south, where tensions between elites and vulnerable people are familiar.
On the consequences of AI bias: when moral values supersede algorithm bias
Authors: Asante Kwadwo , Sarpong David , Boakye Derrick 
Published: October 2024

PurposeThis study responded to calls to investigate the behavioural and social antecedents that produce a highly positive response to AI bias in a constrained region, which is characterised by a high share of people with minimal buying power, growing but untapped market opportunities and a high number of related businesses operating in an unregulated market.Design/methodology/approachDrawing on empirical data from 225 human resource managers from Ghana, data were sourced from senior human resource managers across industries such as banking, insurance, media, telecommunication, oil and gas and manufacturing. Data were analysed using a fussy set qualitative comparative analysis (fsQCA).FindingsThe results indicated that managers who regarded their response to AI bias as a personal moral duty felt a strong sense of guilt towards the unintended consequences of AI logic and reasoning. Therefore, managers who perceived the processes that guide AI algorithms' reasoning as discriminating showed a high propensity to address this prejudicial outcome.Practical implicationsAs awareness of consequences has to go hand in hand with an ascription of responsibility; organisational heads have to build the capacity of their HR managers to recognise the importance of taking personal responsibility for artificial intelligence algorithm bias because, by failing to nurture the appropriate attitude to reinforce personal norm among managers, no immediate action will be taken.Originality/valueBy integrating the social identity theory, norm activation theory and justice theory, the study improves our understanding of how a collective organisational identity, perception of justice and personal values reinforce a positive reactive response towards AI bias outcomes.
Business groups and firm-specific characteristics: influences on entrepreneurial orientation
Authors: Tiwari Santosh Kumar , Shaik Rihana , Vidyarthi Harishankar , Chitre Chetan , Kommu Ravishankar Venkata 
Published: October 2024

PurposeThe purpose of this study is to investigate the impact of business group (BG) affiliation on affiliated firms' entrepreneurial orientation (EO). The authors further investigate the possible contingent factors affecting this relationship – the age of BGs and the affiliated firm’s external linkages (ratio of external to in-house interlocks) on the relationship in an emerging market context.Design/methodology/approachThe study employs a dynamic panel data framework using the system-generalized method of moments (Sys-GMM) on a sample of 670 NSE-listed Indian firms during the 2006–2019 period. EO is measured through content analysis of the letters to shareholders (LTS) issued by the companies between the period 2006 and 2019.FindingsBG affiliates have more EO than standalone firms, as affiliates can access group-wide resources and capabilities apart from firm-specific resources. Affiliates of older BG have less EO since they are more entrenched in the institutional settings of their BG. Affiliates with more external linkages of board members will have a higher level of EO, as such linkages would subside inertial tendencies by exposing them to novel sets of information, resources and strategic practices. Further, the negative effect of BG age on EO is countered by external linkages. Overall, the study shows that the effect of group affiliation is not uniform and is contingent on the factors we have theorized and tested.Originality/valueThe paper proposes the resource-based view and the institutional void theory as likely candidates for explaining the contribution of BGs towards the EO of its affiliates, especially in the context of emerging markets. The contingent role of BG age highlighted in the paper forewarns managers about the importance of establishing internal mechanisms to preserve the EO in affiliates. Our findings about the positive role played by external linkages of the board members provide one such mechanism that can be leveraged to enhance affiliated firm’s EO.
Preparation and properties of glass fiber/PBAT shape memory composites
Authors: Zhang Yi xuan , Xu Shi , Gao Hongyu , Dong Yubing 
Published: October 2024

Purpose
The purpose of this study is to improve the mechanical properties of PBAT. Polybutylene adipate terephthalate (PBAT) has excellent biodegradability, which has been widely used in various fields, such as biomedical supplies, plastic packaging materials, industrial composting and daily sanitary consumables. However, the application of PBAT is limited by its high production costs and poor mechanical property. In this study, the glass fiber (GF)/PBAT composites were prepared, and the effect of GF and the modifiers on the structure, mechanical properties and shape memory properties of the composites were investigated.

Design/methodology/approach
In this work, GF, 3-aminopropyltriethoxysilane (KH550) and chain extender ADR 4370 were selected as reinforcement, GF and chain extender, respectively. The GF/PBAT, KH550-modified GF/PBAT and ADR-modified GF/PBAT composites were prepared by melt blending, extrusion granulation and hot pressing.

Findings
The study showed that the fracture strength and elongation at break of PBAT decreased with the increasing of GF, and the decline is controlled after addition of KH550 and ADR 3470. When the GF content was low (such as 5 wt% and 10 wt%), KH550 significantly improved the mechanical properties of the composites. When the GF content was high (such as 20 wt% and 25 wt%), the mechanical properties of the composites were obviously improved by addition of ADR 3470. In addition, the shape memory fixity ratios (Rf) and shape memory recovery ratios (Rr) of the composites increased and decreased with increase of GF content, the prestrain and tensile temperature, respectively. Furthermore, the Rf of the KH550 modified GF/PBAT composites were the lowest, the Rr were the highest than that of the ADR modified GF/PBAT composites and the untreated GF/PBAT composites.

Research limitations/implications
GF/PBAT composites exhibited good mechanical properties and low production costs. The research can help promote the widespread use of PBAT and alleviate the situation of serious plastic pollution.

Originality/value
A novel biodegradable GF/PBAT composite was developed by chain extender ADR 4370, incorporating environmentally friendly GF with excellent mechanical properties into PBAT.
Playing the System: Electoral Bias in the 2024 UK General Election
Authors: Pattie Charles , Cutts David 
Published: October 2024

AbstractThe UK's 2024 general election was the least proportional of modern times. Labour's substantial parliamentary majority rested on the smallest ever winning party vote share. The Conservatives, meanwhile, suffered one of their worst ever results. While political and economic events during the 2019–2024 Parliament were key to the outcome, the operation of the first past the post electoral system was also important. In 2024, it was strongly biased in Labour's favour and against the Conservatives, contributing substantially to the scale of their defeat and of Labour's victory, allowing Labour to parlay modest support into a large majority. This pro‐Labour bias was to a large extent a result of the much greater efficiency of Labour's geography of support. We place the relative Conservative‐Labour bias at the 2024 contest into a longer historical perspective, demonstrating that it marked the abrupt end of a ten‐year period in which electoral bias had favoured the Conservatives.