bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volumetric analysis of chin and mandibular retromolar region as donor sites for cortico‐cancellous bone blocks
Authors: Zeltner Marco , Flückiger Laura B. , Hämmerle Christoph H. F. , Hüsler Jürg , Benic Goran I. 
Published: January 2016

AbstractAimTo test whether the mandibular retromolar region renders different results from the chin region with respect to the amount of bone available for the harvesting of block grafts.Material and methodsSixty cone beam computed tomography (CBCT) scans of mandibles of adult patients without pathologic findings in the chin and retromolar region were included. According to the number of mandibular teeth, 20 CBCT data sets were allocated to each of the following groups: group M1: dentition 36–46; group M2: dentition 37–47; and group M3: dentition 38–48. For the potential donor sites in the chin and the retromolar regions, the volume (VChin, VRetro), the length (LChin, LRetro), the height (HChin, HRetro) and the width (HChin, HRetro) were assessed using a computer software. Moreover, the chin was examined for the presence and the localization of the mandibular incisive canal. To compare the donor sites in the chin and in the retromolar regions, the quotients VRetro/VChin, LRetro/LChin, HRetro/HChin and WRetro/WChin were calculated and tested using the Wilcoxon signed‐rank test or the sign test.ResultsThe mean bone volume VChin measured 3.5 ± 1.3 cm3 (SD), whereas the overall VRetro amounted to 1.8 ± 1.1 cm3 (SD). VRetro amounted to 2.6 ± 1.4 cm3 (SD) in the group M1, 1.8 ± 0.5 cm3 in the group M2 and 1.0 ± 0.4 cm3 in the group M3. For the group M1, VRetro/VChin measured 82 ± 39% (P = 0.036). VRetro/VChin reached 57 ± 20% in the group M2 and 32 ± 12% in the group M3 (P < 0.001). The mandibular incisive canal was detected in 97% of the CBCT scans. The distance between the mandibular incisive canal and the apices of the central incisors measured 10.5 ± 3.5 mm.ConclusionThe amount of bone available for the harvesting of cortico‐cancellous blocks in the chin region was superior in comparison with the mandibular retromolar region. In the absence of the second and the third molars, the amount of bone harvestable in the retromolar region reached approximately 80% of the bone volume available in the chin region. In the majority of the cases, the mandibular incisive canal was detected within the donor site in the chin region.
H‐classic: a new method to identify classic articles in Implant Dentistry, Periodontics, and Oral Surgery
Authors: De la Flor‐Martínez Maria , Galindo‐Moreno Pablo , Sánchez‐Fernández Elena , Piattelli Adriano , Cobo Manuel Jesus , Herrera‐Viedma Enrique 
Published: January 2016

AbstractIntroductionThe study of classic papers permits analysis of the past, present, and future of a specific area of knowledge. This type of analysis is becoming more frequent and more sophisticated. Our objective was to use the H‐classics method, based on the h‐index, to analyze classic papers in Implant Dentistry, Periodontics, and Oral Surgery (ID, P, and OS).Material and methodsFirst, an electronic search of documents related to ID, P, and OS was conducted in journals indexed in Journal Citation Reports (JCR) 2014 within the category ‘Dentistry, Oral Surgery & Medicine’. Second, Web of Knowledge databases were searched using Mesh terms related to ID, P, and OS. Finally, the H‐classics method was applied to select the classic articles in these disciplines, collecting data on associated research areas, document type, country, institutions, and authors.ResultsOf 267,611 documents related to ID, P, and OS retrieved from JCR journals (2014), 248 were selected as H‐classics. They were published in 35 journals between 1953 and 2009, most frequently in the Journal of Clinical Periodontology (18.95%), the Journal of Periodontology (18.54%), International Journal of Oral and Maxillofacial Implants (9.27%), and Clinical Oral Implant Research (6.04%). These classic articles derived from the USA in 49.59% of cases and from Europe in 47.58%, while the most frequent host institution was the University of Gothenburg (17.74%) and the most frequent authors were J. Lindhe (10.48%) and S. Socransky (8.06%).ConclusionThe H‐classics approach offers an objective method to identify core knowledge in clinical disciplines such as ID, P, and OS.
Bacterial influence on consolidation of bone grafts in maxillary sinus elevation
Authors: Carreño Carreño Javier , González‐Jaranay Maximino , Gómez‐Moreno Gerardo , Aguilar‐Salvatierra Antonio , Menéndez López‐Mateos María Luisa , Menéndez‐Núñez Mario 
Published: January 2016

AbstractObjectivesThe aim of this study was to identify microorganisms present on the maxillary sinus floor at the moment of sinus elevation surgery and, using tomography, to investigate the repercussions these might have for regenerated bone 9 months after the procedure.Materials and methods174 patients (90 women and 84 men) with a mean age of 55.92 years underwent 227 sinus elevations (120 left sinus, 107 right sinus). As the membrane was lifted, a sample of the maxillary sinus floor was collected with a cotton swab, and placed on a blood agar and chocolate agar culture to incubate for 48 h at 37°C; the samples then underwent microbiological analysis. Orthopantomographs and computerized tomographs were made immediately after the sinus grafting and after 9 months to measure the amount of remaining and regenerated bone in vertical and transversal direction.Results18.1% of 227 cultures were bacteria‐positive. 45% of the germs were of the Streptococcus genus, most of which belonged to the S. viridans group (61.1%). Patients presenting negative cultures had 5% more regenerated bone than patients with bacteria‐positive cultures, which represents an additional 2.28 mmof vertical bone (with a confidence interval between 0.83 mm and 3.73 mm).ConclusionsPatients with bacteria‐positive cultures obtained previously to the sinus grafting procedure have greater risk of bone height loss after 9 months, which indicates that bacterial contamination may influence bone graft regeneration.
Sequential healing of onlay bone grafts using combining biomaterials with cross‐linked collagen in dogs
Authors: Cha Jae Kook , Joo Myung‐Jae , Yoon Sora , Lee Jung‐Seok , Choi Seong‐Ho , Jung Ui‐Won 
Published: January 2016

AbstractObjectivesThe aim of this study was to observe the sequential healing of onlay grafts in terms of the volumetric and histologic changes using different bone substances and absorbable membranes according to the presence of collagen cross‐linking.Material and methodsFour groups involving onlay grafting with different materials were randomly assigned to both sides of the maxillae of 15 beagle dogs: (i) control group without any treatment; (ii) group NN, bovine hydroxyapatite incorporated into a non‐cross‐linked collagen matrix (BHC) + non‐cross‐linked collagen membrane (NCCM); (iii) group NC, BHC + cross‐linked collagen membrane (CCM); and (iv) group CC, porcine hydroxyapatite incorporated into a cross‐linked collagen matrix + CCM. Radiographic and histological analyses were performed after three different healing periods: 4, 8 and 12 weeks.ResultsAt week 4, the bone substances were well localized under the barrier membrane in groups NC and CC, while the bone substances became spread out and flattened in group NN. Similarly, the augmented height was significantly greater in groups NC and CC (2.55 and 2.51 mm, respectively; median) than in group NN (1.96 mm, P < 0.001, both). The percentages of newly formed bone were significantly higher at week 12 than at weeks 4 and 8 in all of the groups. The NCCM showed an earlier angiogenesis pattern than the CCM; however, earlier degradation was observed at week 12.ConclusionCombining biomaterials with cross‐linked collagen might contribute to maintaining its initial morphology with excellent biocompatibility in early healing period of lateral onlay grafts.
The fate of buccal bone around dental implants. A 12‐month postloading follow‐up study
Authors: Merheb Joe , Vercruyssen Marjolein , Coucke Wim , Beckers Ludovic , Teughels Wim , Quirynen Marc 
Published: January 2016

AbstractIntroduction and aimBuccal bone thickness is considered to be an important factor during implant surgery. Its resorption might have an effect on the soft tissue stability and eventually on implant survival. This study aimed to investigate the resorption of the buccal bone over the first 12 months after implant loading.Materials and methodsTwenty‐four subjects (47 implants) were included. The buccal bone thickness was measured during implant surgery at several distances from the implant shoulder using a specifically designed device which allows buccal bone thickness measurements without the elevation of a muco‐periostal flap. These measurements were repeated after 12 months of loading. Sixteen implants were placed flapless and 31 with the elevation of a flap. Of the latter, 19 were placed following a one‐stage protocol and 12 following a two‐stage protocol.ResultsThe mean reduction in buccal bone thickness, when all groups pooled, was 0.26, 0.36, 0.35 and 0.27 mm at the shoulder and 2, 4 and 6 mm apically. Implants with initial bone thickness <1mm (thin buccal plate) did not lose significantly more bone than those with an initial thickness ≥1mm (thick bone plate) except in the ‘open‐flap, one‐stage’ group (P = 0.009). A flapless procedure leads to less bone resorption compared to an open‐flap procedure (P = 0.03). However, the number of surgeries (one stage vs. two stages) did not influence the rate of bone resorption (P = 0.23).ConclusionWithin the limitations of this study, one might question the necessity of having a thick bone plate at the vestibular site of the implant.
Patient‐reported outcomes of implant placement performed concomitantly with transcrestal sinus floor elevation or entirely in native bone
Authors: Franceschetti Giovanni , Rizzi Alessandro , Minenna Luigi , Pramstraller Mattia , Trombelli Leonardo , Farina Roberto 
Published: January 2016

AbstractAimBased on the hypothesis that maxillary sinus floor elevation with a transcrestal approach (tSFE) does not increase the morbidity of implant surgery, the study evaluated the patient‐reported outcomes as well as the type and incidence of complications when implants are placed either concomitantly with tSFE (performed according to Trombelli et al. 2008, 2010a,b) or entirely in native bone.MethodsData from the record charts of patients undergone implant placement for single‐tooth rehabilitation in the posterior maxilla were retrospectively obtained from four clinical centers. Cases for tSFE group were included if they showed an extent of sinus lift ≥4 mm concomitantly to implant placement. Cases for N group were included when implant placement was performed entirely in native bone. Patient‐reported outcomes had been assessed using 100‐mm visual analog scales (postoperative pain, VASpain) and visual rating scales (level of discomfort, VRSdiscomfort; willingness to undergo the same surgery, VRSwillingness). The dose of analgesics had been self‐recorded.ResultsA convenience sample of 14 patients and 17 patients (contributing with one implant site each) treated with tSFE and N, respectively, was obtained for this study. Membrane perforation occurred in 1 tSFE case, without compromising the completion of the procedure. VASpain remained low (<12) in both groups. A tendency of VASpain to decrease with time was observed in both groups. The area under the curve for VASpain (AUCpain), indicating the level of pain experience through the first week following surgery, was 18.0 (IR: 8.5–85.0) and 11.5 (IR: 4.5–18.5) in tSFE and N groups, respectively, with no significant inter‐group differences (P = 0.084). The dose of analgesics was similarly low between groups. No significant inter‐group difference in VRSdiscomfort and VRSwillingness was observed.ConclusionsImplant placement performed either concomitantly with tSFE (according to Trombelli et al. 2008, 2010a,b) or entirely in native bone is associated with limited incidence of complications, low postoperative pain and medication and are both well tolerated.
Faecal lactoferrin is a useful biomarker for mucosal healing in patients with ulcerative colitis during granulocyte and monocyte adsorptive apheresis therapy
Authors: Sagawa T. , Kakizaki S. , Tomizawa T. , Nakayama T. , Tanaka H. , Tojima H. , Sato K. , Kusano M. , Okamura S. , Yamada M. 
Published: January 2016

AbstractAimThe study investigated the value of faecal lactoferrin as a follow‐up biomarker for mucosal healing of ulcerative colitis during granulocyte and monocyte adsorptive apheresis (GMA) therapy.MethodPatients with ulcerative colitis exhibiting a moderate or severe disease activity with a partial Mayo Score (pMS) of over 4 were enrolled in this study. The patients received 10 courses of GMA therapy. The pMS value and faecal lactoferrin level were monitored and compared with the findings of endoscopy until 12 months after the last dose of GMA therapy.ResultsTwenty patients (male:female 11:9) were enrolled in this study. Twelve had total colitis, while six had left‐sided involvement and two had distal proctitis. Thirteen (65.0%) responded to GMA therapy. The faecal lactoferrin levels were significantly decreased in patients who responded to GMA therapy (P < 0.05), whereas the levels did not change in non‐responders. Moreover, the faecal lactoferrin levels correlated with the endoscopic findings (r = 0.792, P < 0.01) and pMS scores (r = 0.529, P < 0.01). The correlation coefficients between the faecal lactoferrin levels and mucosal findings were higher than those observed between the pMS score and mucosal findings.ConclusionThe faecal lactoferrin level is a useful biomarker of the mucosal findings in ulcerative colitis. Although endoscopy is the gold standard, the faecal lactoferrin level can be used as a biomarker during GMA therapy in patients with ulcerative colitis.
High mortality rates after nonelective colon cancer resection: results of a national audit
Authors: Bakker I. S. , Snijders H. S. , Grossmann I. , Karsten T. M. , Havenga K. , Wiggers T. 
Published: January 2016

AbstractAimColon cancer resection in a nonelective setting is associated with high rates of morbidity and mortality. The aim of this retrospective study is to identify risk factors for overall mortality after colon cancer resection with a special focus on nonelective resection.MethodData were obtained from the Dutch Surgical Colorectal Audit. Patients undergoing colon cancer resection in the Netherlands between January 2009 and December 2013 were included. Patient, treatment and tumour factors were analysed in relation to the urgency of surgery. The primary outcome was 30‐day postoperative mortality.ResultsThe study included 30 907 patients. A nonelective colon cancer resection was performed in 5934 (19.2%) patients. There was a 4.4% overall mortality rate, with significantly more deaths after nonelective surgery (8.5% vs 3.4%, P < 0.001). Older patients, male patients and patients with high comorbidity, advanced tumours, perforated tumours, a tumour in the right or transverse colon and postoperative anastomotic leakage were at risk of postoperative death. In nonelective resections, a right‐sided tumour and postoperative anastomotic leakage were associated with high mortality.ConclusionNonelective colon cancer resection is associated with high mortality. In particular, right‐sided resections and patients with tumour perforation are at particularly high risk. The optimization of patients prior to surgery and expeditious operation after diagnosis might prevent the need for a nonelective resection.
Transanal total mesorectal excision for rectal cancer: early outcomes in 50 consecutive patients
Authors: Burke J. P. , Martin‐Perez B. , Khan A. , Nassif G. , de Beche‐Adams T. , Larach S. W. , Albert M. R. , Atallah S. 
Published: January 2016

AbstractAimMinimally invasive approaches to proctectomy for rectal cancer have not been widely adopted due to inherent technical challenges. A modification of traditional transabdominal mobilization, termed transanal total mesorectal excision (TaTME), has the potential to improve access to the distal rectum. The aim of the current study is to assess outcomes following TaTME for rectal cancer.MethodThis is a retrospective analysis of a prospectively maintained database of consecutive patients who underwent TaTME for rectal cancer at a single institution. The study period was from 1 March 2012 to 31 July 2015.ResultsDuring the study period 50 patients underwent TaTME. The median tumour distance from the anal verge was 4.4 (3.0–5.5) cm. The rate of conversion from a planned minimally invasive approach was 2.2%. The median operative time was 267.0 (227.0–331.0) min. The median lymph node yield was 18.0 (12.0–23.8), the macroscopic quality assessment of the resected specimen was incomplete in 2% and the circumferential resection margin positivity rate was 4%. Intra‐operative morbidity occurred in 6% and the 30 day morbidity rate was 36%. The median length of stay was 4.5 (4.0–8.0) days. The median follow‐up was 15.1 (7.0–23.2) months; two patients have developed a local recurrence and eight patients have developed distant recurrence.ConclusionThese data suggest that TaTME for rectal cancer is feasible with an acceptable pathological outcome and morbidity profile. Further data on functional and long‐term survival outcomes are required.
Biodiversity Risks of Adopting Resilience as a Policy Goal
Authors: Newton Adrian C. 
Published: January 2016

AbstractResilience is increasingly being incorporated into environmental policy at national and global scales. Yet resilience is a contested concept, with a wide variety of definitions proposed in the scientific literature, and little consensus regarding how it should be measured. Consequently, adoption of resilience as a policy goal presents risks to biodiversity conservation, which are considered here in relation to three categories: (1) ambiguity, (2) measurement difficulty, and (3) misuse. While policy makers might welcome the ambiguity of resilience as a concept, as it provides flexibility and opportunities to build consensus, the lack of clear definitions hinders evaluation of policy effectiveness. Policy relating to resilience is unlikely to be evidence‐based, as monitoring will be difficult to implement. Vague definitions also provide scope for misuse. This is illustrated by the case of European forests, where resilience is being used as a justification to promote management interventions that will negatively affect biodiversity. To address these risks, there is a need for standard definitions and measures of resilience to be developed for use in policy. Furthermore, there is a need for guidelines, standards, and identification of best practice in relation to resilience policy, to ensure that its implementation does not contribute to biodiversity loss.
Telemetry‐derived heart rate variability responses to a physical stressor
Authors: Montaño Alexandra , Brown Freddy , Credeur Daniel P. , Williams Michelle A. , Stoner Lee 
Published: January 2016

SummaryAnalysis of heart rate variability (HRV) responses to an orthostatic challenge can be used to investigate autonomic control of heart rate, an index of cardiovascular function. HRV is typically assessed using the electrocardiogram (ECG), which can be impractical for use with large population‐based studies.PurposeTo assess the validity and reliability of telemetry‐derived HRV responses to an orthostatic challenge.MethodsTwenty healthy adults (26 + 5 years, 45% male) were tested on three separate mornings. Following 20‐min supine rest, R‐R intervals were recorded using a telemetric device during three conditions: BASE, TILT and RECOVERY. ECG was simultaneously used on 1 day for validity comparison. Measures of HRV included the following: standard deviation of normal‐to‐normal intervals (SDNN), the root‐mean‐square of successive differences (RMSSD) and the low‐frequency (LF) and high‐frequency (HF) spectral power.ResultsFor all parameters, there was excellent agreement between devices for BASE (r = 0·96–0·99), TILT (r = 0·89–1·00) and RECOVERY (r = 0·96–1·00). For the telemetric device, between‐day intraclass coefficient values for RMSDD, SDNN and HF were all above the 0·75 criterion for each condition, indicating excellent between‐day reliability. For each condition, the reliability coefficient, expressed as a percentage of the mean (RC%), was marginally lower (greater reliability) for RMSDD (RC% 11–13) and SDNN (RC% 10–12) compared to HF (RC% 12–17). However, SDNN did not significantly respond to the orthostatic challenge.ConclusionTelemetric HRV, particularly RMSDD and HF, can be used to provide a sensitive, valid and reliable assessment of autonomic control of heart rate.
The lactate and ventilatory thresholds in resistance training
Authors: Maté‐Muñoz José Luis , Domínguez Raúl , Lougedo Juan H. , Garnacho‐Castaño Manuel V. 
Published: January 2016

SummaryPurposeThis study was designed to identify the lactate threshold (LT) and first ventilatory threshold (VT1) in a graded resistance half‐squat test and determine whether both thresholds are produced at the same workload. A further goal was to compare the visual inspection and algorithm adjustment methods of detecting both thresholds during graded resistance exercise.MethodsTwenty‐four young men completed two test sessions 48 h apart; (i) the one‐repetition maximum (1RM) was determined, (ii) an incremental load test was performed to locateLTandVT1.VT1was calculated in three different ways based on pulmonary ventilation, the ventilatory equivalent of oxygen or the end‐tidal oxygen pressure (asVT1‐VE,VT1‐VE·orVT1‐PetO2,respectively).ResultsLTandVT1were located at the same intensity of exercise during the incremental load test. Using the algorithm method, theLTandVT1‐VEwere estimated at 24·8 ± 4·8% 1RM(50·6 ± 10·5 kg) and 23·7 ± 4·8% 1RM(48·4 ± 10·0 kg), respectively; the difference between the two values being non‐significant (P = 0·127). In addition, positive correlation was observed between the two thresholds(r = 0·761; P<0·001; intraclass correlation coefficient (ICC) (0·864). The visual inspection and algorithm adjustment methods provided similarLTandVT1values (r > 0·796;ICC > 0·885).ConclusionsTheLTandVT1were readily located during the incremental load half‐squat test at similar workloads using both the visual inspection and algorithm adjustment methods. Both thresholds served to define two physiological stages (I,II) corresponding to the zones described for endurance exercise. Thus, bothLTandVT1could be used to prescribe the same intensity of resistance half‐squat exercise.