bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectories of depressive and anxiety symptoms in older adults: a 6‐year prospective cohort study
Authors: Holmes Sophie E. , Esterlis Irina , Mazure Carolyn M. , Lim Yen Ying , Ames David , Rainey‐Smith Stephanie , Fowler Chris , Ellis Kathryn , Martins Ralph N. , Salvado Olivier , Doré Vincent , Villemagne Victor L. , Rowe Christopher C. , Laws Simon M. , Masters Colin L. , Pietrzak Robert H. , Maruff Paul ,   for the Australian Imaging, Biomarkers and Lifestyle Research Group
Published: July 2017

ObjectiveDepressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alzheimer's disease. We sought to identify the determinants of predominant trajectories of depressive and anxiety symptoms in cognitively normal older adults.MethodFour hundred twenty‐three older adults recruited from the general community underwent Aβ positron emission tomography imaging, apolipoprotein and brain‐derived neurotrophic factor genotyping, and cognitive testing at baseline and had follow‐up assessments. All participants were cognitively normal and free of clinical depression at baseline. Latent growth mixture modeling was used to identify predominant trajectories of subthreshold depressive and anxiety symptoms over 6 years. Binary logistic regression analysis was used to identify baseline predictors of symptomatic depressive and anxiety trajectories.ResultsLatent growth mixture modeling revealed two predominant trajectories of depressive and anxiety symptoms: a chronically elevated trajectory and a low, stable symptom trajectory, with almost one in five participants falling into the elevated trajectory groups. Male sex (relative risk ratio (RRR) = 3.23), lower attentional function (RRR = 1.90), and carriage of the brain‐derived neurotrophic factor Val66Met allele in women (RRR = 2.70) were associated with increased risk for chronically elevated depressive symptom trajectory. Carriage of the apolipoprotein epsilon 4 allele (RRR = 1.92) and lower executive function in women (RRR = 1.74) were associated with chronically elevated anxiety symptom trajectory.ConclusionOur results indicate distinct and sex‐specific risk factors linked to depressive and anxiety trajectories, which may help inform risk stratification and management of these symptoms in older adults at risk for Alzheimer's disease. Copyright © 2017 John Wiley & Sons, Ltd.
Dynamic coupling between fMRI local connectivity and interictal EEG in focal epilepsy: A wavelet analysis approach
Authors: Omidvarnia Amir , Pedersen Mangor , Vaughan David N. , Walz Jennifer M. , Abbott David F. , Zalesky Andrew , Jackson Graeme D. 
Published: July 2017

AbstractSimultaneous scalp EEG‐fMRI recording is a noninvasive neuroimaging technique for combining electrophysiological and hemodynamic aspects of brain function. Despite the time‐varying nature of both measurements, their relationship is usually considered as time‐invariant. The aim of this study was to detect direct associations between scalp‐recorded EEG and regional changes of hemodynamic brain connectivity in focal epilepsy through a time‐frequency paradigm. To do so, we developed a voxel‐wise framework that analyses wavelet coherence between dynamic regional phase synchrony (DRePS, calculated from fMRI) and band amplitude fluctuation (BAF) of a target EEG electrode with dominant interictal epileptiform discharges (IEDs). As a proof of concept, we applied this framework to seven patients with focal epilepsy. The analysis produced patient‐specific spatial maps of DRePS‐BAF coupling, which highlight regions with a strong link between EEG power and local fMRI connectivity. Although we observed DRePS‐BAF coupling proximate to the suspected seizure onset zone in some patients, our results suggest that DRePS‐BAF is more likely to identify wider ‘epileptic networks’. We also compared DRePS‐BAF with standard EEG‐fMRI analysis based on general linear modelling (GLM). There was, in general, little overlap between the DRePS‐BAF maps and GLM maps. However, in some subjects the spatial clusters revealed by these two analyses appeared to be adjacent, particularly in medial posterior cortices. Our findings suggest that (1) there is a strong time‐varying relationship between local fMRI connectivity and interictal EEG power in focal epilepsy, and (2) that DRePS‐BAF reflect different aspects of epileptic network activity than standard EEG‐fMRI analysis. These two techniques, therefore, appear to be complementary. Hum Brain Mapp 38:5356–5374, 2017. © 2017 Wiley Periodicals, Inc.
Towards a unified analysis of brain maturation and aging across the entire lifespan: A MRI analysis
Authors: Coupé Pierrick , Catheline Gwenaelle , Lanuza Enrique , Manjón José Vicente ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: July 2017

AbstractThere is no consensus in literature about lifespan brain maturation and senescence, mainly because previous lifespan studies have been performed on restricted age periods and/or with a limited number of scans, making results instable and their comparison very difficult. Moreover, the use of nonharmonized tools and different volumetric measurements lead to a great discrepancy in reported results. Thanks to the new paradigm of BigData sharing in neuroimaging and the last advances in image processing enabling to process baby as well as elderly scans with the same tool, new insights on brain maturation and aging can be obtained. This study presents brain volume trajectory over the entire lifespan using the largest age range to date (from few months of life to elderly) and one of the largest number of subjects (N = 2,944). First, we found that white matter trajectory based on absolute and normalized volumes follows an inverted U‐shape with a maturation peak around middle life. Second, we found that from 1 to 8–10 y there is an absolute gray matter (GM) increase related to body growth followed by a GM decrease. However, when normalized volumes were considered, GM continuously decreases all along the life. Finally, we found that this observation holds for almost all the considered subcortical structures except for amygdala which is rather stable and hippocampus which exhibits an inverted U‐shape with a longer maturation period. By revealing the entire brain trajectory picture, a consensus can be drawn since most of the previously discussed discrepancies can be explained. Hum Brain Mapp 38:5501–5518, 2017. © 2017 Wiley Periodicals, Inc.
Clinical outcomes for patients presenting with N3 head and neck squamous cell carcinoma: Analysis of the National Cancer Database
Authors: Ko Huaising C. , Chen Shuai , Wieland Aaron M. , Yu Menggang , Baschnagel Andrew M. , Hartig Gregory K. , Harari Paul M. , Witek Matthew E. 
Published: July 2017

AbstractBackgroundThere is a paucity of data regarding head and neck squamous cell carcinomas (HNSCCs) and N3 nodal disease.MethodsRetrospective analysis of patients with N3 HNSCC identified in the National Cancer Database (NCDB) was performed.ResultsWe identified 4867 patients with N3 HNSCC treated with primary surgery or chemoradiotherapy (CRT). Propensity‐adjusted median survival was 54.2 and 44.8 months for surgery and CRT, respectively (P = .06). Oropharyngeal primary subsite demonstrated a survival advantage with surgery versus CRT with propensity‐adjusted median survivals of 86.0 and 61.9 months, respectively (P < .05).ConclusionManagement of N3 HNSCC relies largely on CRT. Patients with N3 nodal disease with nonoropharyngeal primary tumors exhibit 5‐year overall survival approaching 30% independent of initial treatment modality. Patients with oropharyngeal primaries exhibit improved outcomes with surgery largely influenced by the human papillomavirus (HPV)‐negative subset. These data represent the most comprehensive analysis of N3 HNSCC outcomes and serves as a foundation for future research and clinical management.
In vivo Raman spectroscopy–assisted early identification of potential second primary/recurrences in oral cancers: An exploratory study
Authors: Malik Akshat , Sahu Aditi , Singh S. P. , Deshmukh Atul , Chaturvedi Pankaj , Nair Deepa , Nair Sudhir , Murali Krishna C. 
Published: July 2017

AbstractBackgroundHigher rates of local recurrences and second primaries, ascribable to field cancerization, are known problem in oral cancers. The present study explored utility of identification of potential recurrences by Raman spectroscopy, which has been shown to identify oral precancers, cancers, and field cancerization in humans and micro‐sized mechanical irritation‐induced tumors in animals.MethodsRaman spectra were acquired from tumor and contralateral normal mucosa in 99 patients with oral cancer who were then followed up for appearance of clinically apparent cancerous lesions. Misclassifications observed in subsequent multivariate statistical analysis between contralateral normal and tumor spectra were correlated with appearance of new malignant lesions.ResultsThe patients with mismatched spectra had 1.5 times higher chances of developing local recurrence. The sensitivity of Raman spectroscopy in predicting the recurrences was 80% and the specificity was 29.7%.ConclusionFindings provide proof‐of‐concept for Raman spectroscopy‐based identification of sites that have higher propensity to progress to carcinomas before becoming clinically apparent. Prospective validation of Raman spectroscopy by including additional oral cavity subsites and use of multifiber bundles may improve rate of identification of recurrence‐prone subjects.
Increased myocardial native T1 relaxation time in patients with nonischemic dilated cardiomyopathy with complex ventricular arrhythmia
Authors: Nakamori Shiro , Bui An H. , Jang Jihye , El‐Rewaidy Hossam A. , Kato Shingo , Ngo Long H. , Josephson Mark E. , Manning Warren J. , Nezafat Reza 
Published: July 2017

PurposeTo study the relationship between diffuse myocardial fibrosis and complex ventricular arrhythmias (ComVA) in patients with nonischemic dilated cardiomyopathy (NICM). We hypothesized that NICM patients with ComVA would have a higher native myocardial T1 time, suggesting more extensive myocardial diffuse fibrosis.Materials and MethodsWe prospectively enrolled NICM patients with a history of ComVA (n = 50) and age‐matched NICM patients without ComVA (n = 57). Imaging was performed at 1.5T with a protocol that included cine magnetic resonance imaging (MRI) for left ventricular (LV) function, late gadolinium enhancement (LGE) for focal scar, and native T1 mapping for diffuse fibrosis assessment.ResultsGlobal native T1 time was significantly higher in patients with NICM with ComVA when compared to patients with NICM without ComVA (1131 ± 42 vs. 1107 ± 45 msec, P = 0.006), and this finding remained after excluding segments with scar on LGE (1124 ± 36 vs. 1102 ± 44 msec, P = 0.006). Native T1 was similar in NICM patients with and without the presence of LGE (1121 ± 39 vs. 1117 ± 48 msec, P = 0.68) and mildly correlated with LV end‐diastolic volume index (r = 0.27, P = 0.005), LV end‐systolic volume index (r = 0.24, P = 0.01), and LV ejection fraction (r = –0.28, P = 0.003). Native T1 value for each 10‐msec increment was an independent predictor of ComVA (odds ratio 1.14, 95% confidence interval 1.03–1.25; P = 0.008) beyond LV function and LGE.ConclusionNICM patients with ComVA have higher native T1 compared to NICM without any documented ComVA. Native myocardial T1 is independently associated with ComVA, after adjusting for LV function and LGE.Level of Evidence: 2Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:779–786.In memoriam: The authors are grateful for Dr. Josephson's inspiring guidance and contributions to this study.
Rural and remote SMEs’ innovative behavior: Is it in the genes or location? An examination of entrepreneurial traits and characteristics
Authors: Blanchard Kevin 
Published: July 2017

AbstractRemote rural businesses have a higher developed form of innovative ability that gives them an innate sense of survival over rural businesses. Innovation and its use within a remote rural environment, is more highly developed with these geographically located businesses. Entrepreneurial characteristics/traits establish a value in relation to the level of innovative capability/ability. Remote rural SMEs have a better understanding of strategic awareness in relation to their customers.
Which board members when you innovate? Board selection as a strategic change for innovation
Authors: Allemand Isabelle , Brullebaut Bénédicte , Galia Fabrice , Zenou Emmanuel 
Published: July 2017

AbstractFirms with high innovation intensity hire directors with specific skills, and different forms of innovation require different profiles of directors. Board members may bring human and social capital that support the innovative strategies of firms. In a sample of 735 French companies, firms with high innovation intensity hire directors with specific skills, while the profiles of directors required on boards are different according to the forms of innovation implemented. Board human capital is important for innovative firms and gives them benchmarks concerning board appointment criteria.
Optimal timing for a technology shift in mature markets of mobile communication
Authors: Adamauskas Saulius , Krušinskas Rytis 
Published: July 2017

AbstractThe new‐generation 5G mobile technology will likely have a business cycle of approximately 24–25 years. Investment timing in the adoption of new technologies is becoming crucial for science and technology‐based companies to remain competitive. Further investment timing depends on the companies’ current financial state. Mobile technology‐based companies have their own resource lifecycle in which technological changes are inevitable and depend on the uncertainty of the market.
Entrepreneurial growth aspirations in challenging environment: The role of institutional quality, human and social capital
Authors: Lajqi Saranda , Krasniqi Besnik A. 
Published: July 2017

AbstractThe role of formal and informal institutions is crucial in forming growth aspirations. Firms use their resources and personal network, trusting to overcome or compensate for inadequate informal institutions. Transition countries can unlock their growth potential by targeting entrepreneurs with high growth aspiration through policy measures (increasing their level of human capital through a higher quality of educational system, aligning formal and informal institutions, promoting well‐functioning and impartial courts). Entrepreneurs use the informal institutions to complement deficient or inadequate formal institutions. Firm size as an indicator of better access to resources moderates positively the effects of informal institution barriers by having a positive influence on growth aspiration. Training, networking, and trust have a positive effect on growth aspiration and entrepreneurs use these practices in response to institutional deficiencies (inadequate educational systems, inefficient courts and other formal institutions). Policy initiatives should consider small firms as being affected by formal institutions.
Linking strategic orientation with performance: Implication for Indian banks
Authors: Bapat Dhananjay 
Published: July 2017

AbstractWhile cost orientation is found to be the major antecedent to perceived performance, innovation orientation moderates the relationship between both the competitive orientation and performance, and the customer orientation and performance. This article explores the relationship between strategy and performance in the context of the Indian banking sector. Cost orientation is identified as the major determinant for perceived performance. Innovation orientation moderates the relationship between both the competitive orientation and performance, and the customer orientation and performance. Banks need to reorient the marketing strategy to derive long‐term performance benefits, since too much focus on cost orientation may prevent existing banks adapting to the market.
In‐gel and OFFGEL‐based proteomic approach for authentication of meat species from minced meat and meat products
Authors: Naveena Basappa M , Jagadeesh Deepak S , Kamuni Veeranna , Muthukumar Muthupalani , Kulkarni Vinayak V , Kiran Mohan , Rapole Srikanth 
Published: July 2017

AbstractBACKGROUNDFraudulent mislabelling of processed meat products on a global scale that cannot be detected using conventional techniques necessitates sensitive, robust and accurate methods of meat authentication to ensure food safety and public health. In the present study, we developed an in‐gel (two‐dimensional gel electrophoresis, 2DE) and OFFGEL‐based proteomic method for authenticating raw and cooked water buffalo (Bubalus bubalis), sheep (Ovis aries) and goat (Caprus hircus) meat and their mixes.RESULTSThe matrix‐assisted liquid desorption/ionization time‐of‐flight mass spectrometric analysis of proteins separated using 2DE or OFFGEL electrophoresis delineated species‐specific peptide biomarkers derived from myosin light chain 1 and 2 (MLC1 and MLC2) of buffalo–sheep–goat meat mix in definite proportions at 98:1:1, 99:0.5:0.5 and 99.8:0.1:0.1 that were found stable to resist thermal processing. In‐gel and OFFGEL‐based proteomic approaches are efficient in authenticating meat mixes spiked at minimum 1.0% and 0.1% levels, respectively, in triple meat mix for both raw and cooked samples.CONCLUSIONSThe study demonstrated that authentication of meat from a complex mix of three closely related species requires identification of more than one species‐specific peptide due to close similarity between their amino acid sequences. © 2017 Society of Chemical Industry
Organic carbon patterns and budgets in the Long Island Sound estuary
Authors: Vlahos Penny , Whitney Michael M. 
Published: July 2017

AbstractA multi‐year observational time series was evaluated across the 150 km central axis of the U.S. east coast's Long Island Sound (LIS) estuary, in three distinct regions. Fluxes were calculated at the boundaries of the regions using observations coupled to a hydrodynamic model and applied to a mass balance to assess organic carbon (OC) export from LIS. For all years, during stratified summer periods, LIS was a net exporter of OC to the continental shelf. LIS annual net carbon export however, varied with river flow. The heterotrophic or autotrophic nature of LIS also shifted inter‐annually. During the mass balance analysis period (2009–2012), LIS ranged between net OC import from the continental shelf and heterotrophy in the lowest river flow year (2012) and net export of OC and autotrophy in the highest flow year (2011). Analysis suggests that LIS switches from net OC import to export when the annual river inputs exceed 19 km3 yr−1. Applying these thresholds to the annual river flow record suggests that net import occurred in 15% of the last 20 years and that LIS usually is a net exporter of OC (85%). Annually averaged LIS carbon export values based on river flow conditions over the last 20 yr are estimated at 56 ± 64 × 106 kg yr−1. Analysis also suggests that LIS shifts from net heterotrophic to net autotrophic when annual river flow exceeds 26 km3 yr−1 (35% of the last 20 yr). Net heterotrophic conditions are most common, representing 65% of the last 20 yr.
Advancing Graduate Limnology Education Through Active Learning and Community Partnerships: A Pilot Program at the Large Lakes Observatory
Authors: Schreiner Kathryn M. , Katsev Sergei , Steinman Byron , Sterner Robert W. , Williams Julia , Zak Kevin 
Published: July 2017

AbstractAt the Large Lakes Observatory at the University of Minnesota Duluth (UMD), we are addressing issues with an outdated limnology graduate curriclum by designing a flipped‐classroom, interdisciplinary limnology course sequence that incorporates partnerships with industry, meaningful field and analytical work, and integrated skills learning for our graduate students. This new curriculum is co‐taught by four instructors with different research backgrounds and is meant to teach students with a wide range of undergraduate preparation without significant time spent on in‐class review, or leaving anyone behind. The courses, which include lecture and practice classes each semester in the graduate students' first year, are built around a course website, www.studywater.org, which will go public in fall of 2018. Funded by the National Science Foundation Division of Graduate Education, this pilot program will provide a new interdisciplinary curriculum applicable to graduate limnology programs and a public website with limnology modules designed to be searchable and open to the public. Here, we describe in detail our new course sequence, including curriculum, industry partnerships, and field work with the students; provide information on the challenges we faced in developing and teaching this course; and our advice for overcoming those challenges.
Enhanced Photoelectric and Photothermal Responses on Silicon Platform by Plasmonic Absorber and Omni‐Schottky Junction
Authors: Wen Long , Chen Yifu , Liu Wanwan , Su Qiang , Grant James , Qi Zhiyang , Wang Qilong , Chen Qin 
Published: July 2017

AbstractRecent progresses in plasmon‐induced hot electrons open up the possibility to achieve photon harvesting beyond the fundamental limit imposed by band‐to‐band transitions in semiconductors. To obtain high efficiency, both the optical absorption and electron emission/collection are crucial factors that need to be addressed in the design of hot electron devices. Here, we demonstrate a photoresponse as high as 3.3mA/W at 1500nm on a silicon platform by plasmonic absorber (PA) and omni‐Schottky junction integrated photodetector, reverse biased at 5V and illuminated with 10mW. The PA fabricated on silicon consists of a monolayer of random Au nanoparticles (NPs), a wide‐band gap semiconductor (TiO2) and an optically thick Au electrode, resulting in broadband near‐infrared (NIR) absorption and efficient hot‐electron transfer via an all‐around Schottky emission path. Meanwhile, time and spectral‐resolved photoresponse measurements reveal that embedded NPs with superior absorption resembling plasmonic local heating sources can transfer their energy to electricity via the photothermal mechanism, which until now has not been adequately assessed or rigorously differentiated from the photoelectric process in plasmon‐mediated photon harvesting nano‐systems.