bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract B25: Triple-negative breast tumors exhibit distinctive patterns of expression and subcellular localization of Insulin-like Growth Factor Binding Protein 6
Authors: Ford DeJuana , Hire Rupali , Howerth Elizabeth , Bennett Briana , Lea Krissean , Hood Jillian , Davis Melissa 
Published: May 2016

Abstract
African-American women of all ages have higher breast cancer mortality rates than Caucasian women, despite lower breast cancer incidence among African-American women over 40. While differences in socioeconomic status and access to healthcare may play a role in this disparity, the disproportionately high occurrence of aggressive, triple-negative breast tumors in African-American women suggests a biological link between ancestry and breast cancer prognosis. Interestingly, both African ancestry and breast tumor aggressiveness are associated with distinct transcript and protein expression levels of Insulin-like growth factor-II (IGF-II) and its binding partner, Insulin-like growth factor binding protein 6 (IGFBP6), and we have previously observed higher levels of IGFBP6 transcript and protein expression in African-American and Yoruba (African) HapMap cell lines when compared to Amish cell lines. To gain a better understanding of potential mechanisms underlying these associations, we have investigated the expression and subcellular localization of these proteins and their transcripts using qPCR and immunofluorescence (IF). Our qPCR data indicate lower IGFBP6 transcript expression in breast cancer cells relative to normal cells, with lower transcript levels in the ER positive breast cancer cells than in triple negative cells. Conversely, our IF data revealed higher levels of IGFBP6 protein in ER positive breast cancer cells than in triple negative breast cancer cells, suggesting that breast tumor subtypes may be associated with unique patterns of transcript and protein regulation in these genes. We also observed a distinctive pattern of IGFBP6 subcellular localization in the triple-negative cells in which aggregates of this protein are localized at the edge of the nucleus, and co-localized with IGF-II. We hypothesize that IGF-II will be more dispersed throughout the nucleus following si-RNA knockdown of IGFBP6. Taken together, these data suggest the possibility of a subtype-specific IGF-II/IGFBP6 complex in triple negative breast cancer. Further studies will assess how this complex may promote tumor aggression in triple-negative breast tumors by inhibiting IGFBP6's IGF-independent, pro-apoptotic qualities within the nucleus and/or prolonging the half-life of IGF-II, thus promoting cancer cell growth.
Citation Format: DeJuana Ford, Rupali Hire, Elizabeth Howerth, Briana Bennett, Krissean Lea, Jillian Hood, Melissa Davis. Triple-negative breast tumors exhibit distinctive patterns of expression and subcellular localization of Insulin-like Growth Factor Binding Protein 6. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr B25.
Abstract B38: Behavioral and clinical correlates of hepatocellular carcinoma among residents of South Central Texas: A case-control study
Authors: Ramirez Amelie G. , Muñoz Edgar , Long-Parma Dorothy , Holden Alan E.C. , Treviño Allen M. , Phillips Timothy D. , Pollock Bradley 
Published: May 2016

Abstract
Latinos in South Texas (STX) are disproportionately diagnosed with Hepatocellular Carcinoma (HCC) compared to non-Hispanic whites (NHW) and Latinos in the U.S. The aims of this study were to characterize behavioral and clinical risk factors contributing to HCC incidence in our STX population.
Methods: Controls and cases (104:51) were recruited from Bexar and 5 surrounding counties. Blood and urine samples were obtained from each subject and tested for liver function, Hepatitis B and C exposure, and blood/urine aflatoxin levels. Demographic and lifestyle data were obtained via questionnaire. Chi-squared and t-test analysis was utilized to determine bivariate case-control differences.
Results: In bivariate analyses, HCC cases were older (57.3 vs. 49.7, p&lt;0.001), and more likely to be male (OR = 8.44, p&lt;0.001) or Latino (OR=2.17, p=0.045). HCC cases were also more likely to use alcohol (p&lt;0.001) or smoke (p&lt;0.001). They also were less likely to use aspirin (p=0.003) or statins (p=0.049) and less likely to engage in physical activity (p=0.038). Finally, HCC cases were more likely to have abnormal aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (p&lt; 0.001 for both), and higher levels of serum aflatoxin B1 (AFB1) (p=0.014).
Conclusions: Findings confirm bivariate relationship between HCC incidence and risk factors in the general population.
Citation Format: Amelie G. Ramirez, Edgar Muñoz, Dorothy Long-Parma, Alan E.C. Holden, Allen M. Treviño, Timothy D. Phillips, Bradley Pollock. Behavioral and clinical correlates of hepatocellular carcinoma among residents of South Central Texas: A case-control study. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr B38.
Abstract B70: Characteristics, risk perception, and predictors of oral cancer knowledge among drag racers and their fans
Authors: Osazuwa-Peters Nosayaba , Hussaini Adnan S. , Sujijatarat Nanthiya , Ganesh Rajan , Snider Matthew , Devin Thompson , Varvares Mark A. 
Published: May 2016

Abstract
Objective: Interventions for oral head and neck cancer prevention and early detection can be more effective if the higher risk individuals are targeted. The aim of this study was to characterize smoking and alcohol use, and describe predictors of oral cancer knowledge and risk perception among a predominantly African-American population.
Methods: A cross-sectional study was conducted between September 13-14, 2013 among drag racers and fans in East St. Louis. Items were combined to form knowledge and risk perception scales, and outcome of interest was oral cancer knowledge level. Independent t-tests and one-way ANOVA assessed bivariate associations between variables. Logistic regression analysis measured predictors of oral cancer knowledge.
Results: Three hundred and four participants completed questionnaire; 72.9% African Americans. Smoking rate was 26.7%; mean knowledge score 4.60 ± 2.52; and only 6.6% scored ≥ 9 out of 17 knowledge questions. Crude measures showed an association (p &lt; .05) between oral cancer knowledge and sociodemographic variables (age, race, sex, educational status, marital status). In final adjusted regression model, only race and educational status remained predictors of oral cancer knowledge. Compared to other races, African Americans were three times more likely to have low oral cancer knowledge (95% CI = 1.47 – 6.49) and those with a high school diploma or less were five times more likely to have low oral cancer knowledge compared to college graduates (95% CI = 1.78 – 13.89).
Conclusion and Relevance: There is a high smoking rate among drag racers and fans, but oral cancer knowledge is very low, especially among African Americans and those with limited education. Understanding predictors of oral cancer knowledge is important in future design of educational interventions specifically targeted towards this high-risk group.
Citation Format: Nosayaba Osazuwa-Peters, Adnan S. Hussaini, Nanthiya Sujijatarat, Rajan Ganesh, Matthew Snider, Thompson Devin, Mark A. Varvares. Characteristics, risk perception, and predictors of oral cancer knowledge among drag racers and their fans. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr B70.
Abstract B92: The effectiveness of a prostate cancer handout for African American men
Authors: McCauley DeCoria , Young Mary Ellen , Hardt Nancy 
Published: May 2016

Abstract
The purpose of this study is to explore consumer reaction to a revised handout previously created for African American men (UF IRB02 Protocol #2013-U-0757) in order to prepare for widespread publishing and distribution. The population of interest in this particular study is African American men as they are the most at risk for prostate cancer. African American men between the ages of 20 and 70 will be given patient education materials on prostate cancer prepared for men with lower literacy levels. After being given time to review the materials, they will participate in an interview to determine how well they understood the information in the patient education materials. Their feedback will guarantee the development of appropriate material to provide to the African American male community; and inform the general population on how members of a special/minority population feel about the primary cancer found in men, prostate cancer.
Citation Format: DeCoria McCauley, Mary Ellen Young, Nancy Hardt. The effectiveness of a prostate cancer handout for African American men. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr B92.
Abstract C13: What strategies may be effective to address erectile dysfunction following treatment of prostate cancer in men of color?
Authors: Jeames Sanford , Imholte Shelley 
Published: May 2016

Abstract
Men of color in the United States continue to experience significant gaps in health conditions and mental health treatment options for cancer, diabetes and heart disease as compared with other ethnic groups. This is not a new issue, but rather a continuing problem that has plagued both the health and mental healthcare industry for decades. While all racial ethnicities are worthy of attention; African American men presenting with erectile dysfunction (ED) after treatment of prostate cancer in a mental health setting are the focus of this work. Reports of ED among African American men are far more common in medical settings and in these settings men in general and African American men in particular are rarely assessed for mental or emotional distress related to ED. In order for change to be possible to address mental health disparities in African American men, providers (urologists, oncologists, psychotherapists, psychologists, social workers, and counselors) must begin to acknowledge their own race in communication with this population to develop a therapeutic alliance. Clinicians skilled in cultural variations may not be skilled in discussions of sexuality and clinicians skilled in sexual concerns may not be skilled in discussions of culture and the impact of ethnicity on overall well-being. If strategies are not employed and tested the mental health disparities in African American men are sure to increase. In the present day, race relations are in grave danger of regressing into a history that has been challenged to change for centuries. The under-served are truly being under-served in this way due to the disproportionate numbers of clinicians, and perhaps more importantly; the lack of clinicians in training that are not taught to take ownership or create a relationship that invites differences rather than avoid it. The reason for this particular position and condition has been chosen is because of the relevance to current relations and history; along with the dire need to address sexuality in minority populations. Moreover, stereotypes of African American men as sexually “aggressive” and “weak” if they show emotions outside of aggression further stifle the exploration of etiologies of ED in this population. If strategies are not employed and rigorously tested mental and sexual health in AA will be rendered impotent.
Citation Format: Sanford Jeames, Shelley Imholte. What strategies may be effective to address erectile dysfunction following treatment of prostate cancer in men of color? [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr C13.
Abstract C30: Disparities in colorectal cancer survival among Puerto Rican Hispanics
Authors: Gonzalez-Pons Maria , Torres Mariela , Soto-Salgado Marievelisse , Marcano-Bonilla Lorena , Cruz-Correa Marcia 
Published: May 2016

Abstract
Background: Ethnic/racial disparities in colorectal cancer (CRC) survival have been well documented. In Puerto Rico (PR), CRC is the leading cause of cancer death in men and women. This study reports the 5-year relative survival of Puerto Rican Hispanic (PRH) CRC patients compared to other US racial/ethnic groups and estimates the mortality hazard ratio by sex, age, and tumor stage at diagnosis.
Methods: CRC incidence data from subjects &gt;50 years was obtained from the Puerto Rico Central Cancer Registry from January 1, 2001 to December 31, 2003. CRC incidence and mortality data for US Hispanics (USH), non-Hispanic White (NHW) and non-Hispanic black (NHB) during the same period were obtained from the Surveillance, Epidemiology and End Results (SEER) database. One-, three- and five-year relative survival rates were calculated using the life tables from the population of PR and SEER. In addition, a Cox proportional hazards model was employed to assess mortality hazard ratio by sex, age and tumor stage at diagnosis.
Results: A total of 76,444 subjects with incident CRC were analyzed (NHW n=59,686; NHB n=7,700; USH n=5,699; PRH n=3,359). Overall and stage-specific five-year survival rates differed by race/ethnicity. NHW had the highest overall survival rates. When comparing 5-year relative survival according to stage at diagnosis, PRH with regional CRC had the lowest five-year survival rates (59.3%; 95% CI: 53.5-65.0) when compared to NHW (69.4%; 95% CI: 67.9-70.9), NHB (61.2%; 95% CI: 56.9-65.8), and USH (65.1%; 95% CI: 59.9-70.1). Furthermore, PRH were the only racial/ethnic group in which a more marked survival advantage is was observed among females (66.0%; 95% CI: 60.6-71.2) compared to males (60.3%; 95% CI: 54.6-65.9). After adjusting by sex, age and stage at diagnosis, NHB (RR=1.27; CI 95%: 1.22-1.32) and PRH (RR=1.28; CI 95%: 1.09-1.28) had nearly the same relative risk of death from CRC, compared to NHW.
Conclusions: Our findings establish baseline survival data for CRC in PRH. The observed survival disparities among PRH warrant further investigation evaluating the interplay of molecular, behavioral and/or environmental risk factors affecting this minority population.
Citation Format: Maria Gonzalez-Pons, Mariela Torres, Marievelisse Soto-Salgado, Lorena Marcano-Bonilla, Marcia Cruz-Correa. Disparities in colorectal cancer survival among Puerto Rican Hispanics. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr C30.
Abstract C45: A patient navigation model to increase rates of lung-directed therapy with curative intent (LDTCI) in African Americans with early stage non-small cell lung cancer (NSCLC)
Authors: Esnaola Nestor F. , Bryant Debbie C. , Cartmell Kathleen B. , Calhoun Elizabeth , Sterba Katherine , Burshell Dana R. , Hill Elizabeth G. , Wahlquist Amy E. , Knight Kendrea D. , Ford Marvella E. 
Published: May 2016

Abstract
Background: LDTCI (i.e., surgical resection or stereotactic body radiation therapy [SBRT] in patients who are not surgical candidates]) is the standard of care for patients with early stage NSCLC. Unfortunately, African Americans with early stage, NSCLC are significantly less likely than their European American counterparts to undergo resection.
Purpose: This presentation will describe the design of an NIH/NIMHD-funded, NCORP-sponsored, cluster-randomized trial testing the effectiveness of a barriers-focused, protocol-driven patient navigation intervention on increasing rates of LDTCI in African Americans with early stage, probable/proven NSCLC.
Design: The trial is currently being conducted at 13 study sites across the United States. The investigators developed an electronic, web-based version of the NIH/NCI Patient Navigation Barrier Checklist. Patient navigators at each intervention site use the electronic Checklist to identify patient barriers to care and guide their interactions with patients. The navigators then enter the data from these interactions into a secure, web-based electronic data management system.
Results/Conclusions: Most of the African American patients at the study sites are ineligible for study participation due to advanced stage at diagnosis. Of the 2,529 patients who have been pre-screened for study eligibility to date, only 43 (1.7%) were determined to be African American with likely/proven stage I-II NSCLC. Of this number, 34 (79.1%) were consented for the study, and 29 are currently enrolled. During this presentation, the investigators will present de-identified case examples of barriers experienced by patients and the strategies used by the navigators to overcome these barriers. Plans are underway to add study sites to increase the denominator of potentially eligible participants.
Citation Format: Nestor F. Esnaola, Debbie C. Bryant, Kathleen B. Cartmell, Elizabeth Calhoun, Katherine Sterba, Dana R. Burshell, Elizabeth G. Hill, Amy E. Wahlquist, Kendrea D. Knight, Marvella E. Ford. A patient navigation model to increase rates of lung-directed therapy with curative intent (LDTCI) in African Americans with early stage non-small cell lung cancer (NSCLC). [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr C45.
Abstract C57: Obesity induced leptin-tumor stroma crosstalk in breast cancer: A link to cancer health disparity
Authors: Lanier Viola D. , Milner Joy , Harbuzariu Adriana , Bowen Diane , Gonzalez-Perez Ruben Rene 
Published: May 2016

Abstract
Breast cancer cells can change tumor stromal cells by promoting growth, angiogenesis, invasion, and metastasis. Obesity is a risk factor of breast cancer, which is characterized by high levels of leptin. African American women show the highest incidence of obesity, most aggressive breast cancer, and highest mortality rate. Adipocytes and breast cancer cells synthesize leptin, which is a survival, pro-angiogenic, and proliferation factor for cancer cells; and also could affect tumor stromal cells [i.e, endothelial (EC) and fibroblasts]. Activated stromal cells could further contribute to the production of a tumor supportive extracellular matrix; thus, creating an ideal environment for the growth of cancer cells. We previously reported that leptin induces the expression of oncogenic and angiogenic factors (i.e, Notch and VEGF/VEGFR-2) in cancer cells and also a VEGFR-Notch axis in EC. However, the mechanisms by which leptin affects fibroblasts to promote cancer progression are not completely understood. We hypothesize that leptin induces Notch expression and activity that increase fibroblast proliferation and activation. Fibroblast cells (mouse embryonic NIH/3T3 stem and human cells) were challenged with leptin (0.6, 1.2, 6.2 nM) and inhibitors of Notch (DAPT). Notch proteins and mRNA, and leptin receptor (Ob-R) expression and fibroblast activation markers were determined after treatments. Our findings show that leptin induces Notch expression, proliferation and activation of embryonic fibroblast stem cells. This data further sustains the notion that high levels of leptin found in obese patients could contribute to tumor stroma activation and cancer development. Novel therapies targeting leptin signaling could be a new strategy for breast cancer prevention and treatment, which could be more relevant for obese African American breast cancer patients.
Citation Format: Viola D. Lanier, Joy Milner, Adriana Harbuzariu, Diane Bowen, Ruben Rene Gonzalez-Perez. Obesity induced leptin-tumor stroma crosstalk in breast cancer: A link to cancer health disparity. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr C57.
Abstract C81: Variations in receipt of curative-intent surgery for early-stage non-small cell lung cancer (NSCLC) across states in the United States
Authors: Sineshaw Helmneh M. , Wu Xiao-Cheng , Flanders W Dana , Osarogiagbon Raymond Uyiosa , Jemal Ahmedin 
Published: May 2016

Abstract
Background: Previous studies reported substantial racial and socioeconomic disparities in receipt of curative-intent surgery for early-stage non-small cell lung cancer (NSCLC) in the US. We examined variation in receipt of curative-intent surgery for early-stage non-small cell lung cancer (NSCLC) across states in the US. We also examined whether black/white disparity in receipt of curative-intent surgery varies by state.
Methods: Patients with stage I or II NSCLC diagnosed in 2007–2011 were identified from 38 population-based cancer registries compiled by the North American Association of Central Cancer Registries (NAACCR). We calculated percentage for receipt of curative-intent surgery in each state. Adjusted risk ratios (RRs) were generated using modified Poisson regression to control for sociodemographic (e.g., age, sex, race, insurance) and clinical (e.g., grade, stage, tumor size) factors. NH whites and patients in Massachusetts used as reference for comparisons.
Results: Receipt of curative-intent surgery for early-stage NSCLC varied substantially by state, ranging from 52.2% in Wyoming to about 75% in Massachusetts, New Jersey, and Utah. In a multivariable analysis, the likelihood of receiving curative-intent surgery for early-stage NSCLC patients was significantly lower in all states but seven states/registries and ranged from 7% lower in California (RR, 0.93; 95% CI, 0.89–0.97) to 25% lower in Wyoming (RR, 0.75; 95% CI, 0.59–0.95) compared with patients in Massachusetts. Receipt of curative-intent surgery was lower for NH black than NH white patients in all states though statistically significant in only two states (Florida, Texas) after accounting for differences in sociodemographic and clinical characteristics.
Conclusions: Receipt of curative-intent surgery for early-stage NSCLC substantially varies across states in the United States, with the rate of receipt for both NH white and NH black patients generally lower and racial disparity higher in southern states.
Citation Format: Helmneh M. Sineshaw, Xiao-Cheng Wu, W Dana Flanders, Raymond Uyiosa Osarogiagbon, Ahmedin Jemal. Variations in receipt of curative-intent surgery for early-stage non-small cell lung cancer (NSCLC) across states in the United States. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr C81.