bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydration Status and Thermoregulatory Responses in Drivers During Competitive Racing
Authors: Carlson Lara A. , Lawrence Michael A. , Kenefick Robert W. 
Published: October 2017

Abstract
Carlson, LA, Lawrence, MA, and Kenefick, RW. Hydration status and thermoregulatory responses in drivers during competitive racing. J Strength Cond Res 32(7): 2061–2065, 2018—Stock car drivers are exposed to high ambient temperatures, further complicated by the fact that they are encapsulated in protective clothing; however, the hydration status of these drivers has not been determined. This study quantified the degree of fluid losses during a competitive event in hot conditions. Nine male stock car drivers (29.6 ± 9.4 years, 177.8 ± 3.0 cm, 81.5 ± 18.5 kg) were studied during a Pro Series Division NASCAR race. Sweat rate (SR) and dehydration was determined through nude body weights (BWs). Prerace BW was 81.5 ± 18.5 kg and decreased to 81.1 ± 18.5 kg after race (p = 0.001). Body weight loss after race was 0.77 ± 0.3% and mean SR was 0.63 ± 0.4 L·h−1. Intestinal core temperature increased from 38.0 ± 0.4 to 38.5 ± 0.4° C after race (p = 0.001). Skin temperature increased from 35.8 ± 0.8 to 36.9 ± 0.8° C after race (p = 0.001), whereas the core-to-skin temperature gradient narrowed from 2.2 ± 0.9 to 1.6 ± 0.9° C, before race to after race (p = 0.001). Heart rates after race were 89 ± 0.0% of the drivers' age-predicted maximum heart rate (HR). Fluid losses during competitive racing can be significant. Without a fluid replacement strategy, fluid losses may exceed 3% of BW and could negatively impact driving performance in longer races.
Revisiting the Single-Visit Protocol for Determining the Electromyographic Fatigue Threshold
Authors: Khan Fatin L. , Lawal Jordan M. , Kapture Drew O. , Swingle Joseph D. , Malek Moh H. 
Published: October 2017

Abstract
Khan, FL, Lawal, JM, Kapture, DO, Swingle, JD, and Malek, MH. Revisiting the single-visit protocol for determining the electromyographic fatigue threshold. J Strength Cond Res 31(12): 3503–3507, 2017—The electromyographic fatigue threshold (EMGFT) has been shown to demarcate between nonfatiguing and fatiguing exercise workloads. One potential limitation of incorporating the single EMGFT test in a clinical setting is the 2-minute stage increment inherit to the protocol. In most rehabilitation clinics, time with the client is limited, and any testing procedure needs to consider this factor. The purpose of this study, therefore, was to determine whether or not the estimation of the EMGFT is influenced by reducing the incremental stage to 1-minute intervals. We hypothesized that the 1-minute incremental protocol would provide similar estimates of the EMGFT as the traditional 2-minute incremental protocol. Nine college-aged men performed the single-leg knee-extensor ergometry at 1-minute (3 W) and 2-minute (6 W) stages in random order separated by 7 days. The exercise indices and the EMGFT were determined from the 2 protocols and analyzed using a paired samples t test. The EMG amplitude was assessed from the rectus femoris muscle. The results indicated significant differences between protocols for maximal power output (1 minute: 31.7 ± 2.2 W vs. 2 minutes: 38.0 ± 3.3 W, p = 0.016) and heart rate at end exercise (1 minute: 137 ± 5 b·min–1 vs. 2 minutes: 148 ± 5 b·min–1, p = 0.024). There were, however, no significant mean differences for the EMGFT (1 minute: 19.8 ± 1.8 vs. 2 minutes: 20.3 ± 1.9 W, p = 0.63) and rating of perceived exertion (RPE) for the exercised leg (1 minute: 9 ± 0 vs. 2 minutes: 9 ± 1, p = 0.68). These results indicate that reducing the exercise protocol by 50% did not change the estimated EMGFT. The practical application of this finding resides in the potential use in sports or rehabilitative settings in which there is limited time with the client and no objective measures to determine neuromuscular fatigue for aerobic exercise.
Effects of Low-Load, Higher-Repetition vs. High-Load, Lower-Repetition Resistance Training Not Performed to Failure on Muscle Strength, Mass, and Echo Intensity in Healthy Young Men: A Time-Course Study
Authors: Ikezoe Tome , Kobayashi Takuya , Nakamura Masatoshi , Ichihashi Noriaki 
Published: October 2017

Abstract
Ikezoe, T, Kobayashi, T, Nakamura, M, and Ichihashi, N. Effects of low-load, higher-repetition vs. high-load, lower-repetition resistance training not performed to failure on muscle strength, mass, and echo intensity in healthy young men: A time-course study. J Strength Cond Res 34(12): 3439–3445, 2020—The aim of this study was to compare the effects of low-load, higher-repetition training (LLHR) with those of high-load, lower-repetition training (HLLR) on muscle strength, mass, and echo intensity in healthy young men. Fifteen healthy men (age, 23.1 ± 2.6 years) were randomly assigned to 1 of the 2 groups: LLHR or HLLR group. Resistance training on knee extensor muscles was performed 3 days per week for 8 weeks. One repetition maximum (1RM) strength, maximum isometric strength, muscle thickness, and muscle echo intensity on ultrasonography of the rectus femoris muscle were assessed every 2 weeks. Analysis of variance showed no significant group × time interaction, and only a significant main effect of time was observed for all variables. The 8-week resistance training increased 1RM, maximum isometric muscle strength, and muscle thickness by 36.2–40.9%, 24.0–25.5%, and 11.3–20.4%, respectively, whereas it decreased echo intensity by 8.05–16.3%. Significant improvements in muscle strength, thickness, and echo intensity were observed at weeks 2, 4, and 8, respectively. The lack of difference in time-course changes between LLHR and HLLR programs suggests that low-load training can exert similar effects on muscle mass and characteristics as high-load training by increasing the number of repetitions, even when not performed to failure.
Effects of Strain Rates on the Undrained Shear Strength of Kaolin
Authors: Nanda S. , Sivakumar V. , Hoyer P. , Bradshaw A. , Gavin K. G. , Gerkus H. , Jalilvand S. , Gilbert R. B. , Doherty P. , Fanning J. 
Published: October 2017

Abstract
In recent times, interest in dynamically installed foundation systems for deep-sea construction has increased; however, these foundation systems are still under development and need quantification of various soil parameters with different perspectives. For the design of dynamically installed foundations, it is essential to assess the strain-rate effect on very soft soils. The T-bar has been widely used to characterize soft offshore sediments, such as silt and clay, and there is extensive existing literature on the interpretation of test results. Strain-rate dependence has not previously been fully examined for T-bar tests in very soft clay at very high rates of penetration. This paper examines this aspect using a physical model test. A 65-cm-thick kaolin clay bed was formed using vacuum consolidation. A T-bar was driven into the clay bed at rates that varied from 0.1 cm/s to 60 cm/s. The tests revealed that the resistance factor increased by 9 % for every 10-fold increase in the penetration rate for the material tested in this research.
Implementation of a Pretensioned, Fully Bonded Bolting System and Its Failure Mechanism Based on Acoustic Emission: A Laboratorial and Field Study
Authors: Feng Xiaowei , Zhang Nong , He Fengzhen , Yang Sen , Zheng Xigui 
Published: October 2017

Abstract
Currently, bolt-support technology is commonly applied throughout the world during mining activities, civil engineering, and hydraulic projects. The theory of a pretensioned and fully bonded bolting system has long been proposed for use as tunnel supports; however, this technology is difficult to implement in coal mining, particularly for roadways that require immediate support. In this study, a modified cement with water-to-cement ratio of 0.25 was used to work in tandem with a traditional resin cartridge to create a pretensioned, fully bonded bolting system. The fast-setting epoxy resin is positioned at the bottom of the borehole for pretension, and the cement is positioned along the rest of the borehole for full-length bonding along the bolt. Based on a series of pullout tests on the proposed bolting system with different pretension forces, this study shows that a pretensioned, fully bonded bolting system is more durable and stable than the end-encapsulated resin bolting system that is currently utilized in most of China’s coal mines. Additionally, an acoustic emission detection test was simultaneously conducted to further describe the inner fracture mechanisms of the bolting system under different pretension forces ranging from 50 to 140 kN, with an increment of 30 kN. The results of this test indicate that a higher pretension force can decrease the damage events in the bolting system. Additionally, the failure form of a pretensioned, fully bonded bolting system is more likely to be dominated by the fracture of the bolt rod in most circumstances. Finally, this combined bolting technology is successfully implemented in a coal mine, and the monitored results confirm that the proposed bolting measure is effective and reliable.
The Use of Carbonation Depth Techniques on Stabilized Peat
Authors: Duggan Alan R. , Goggins Jamie , Clifford Eoghan , McCabe Bryan A. 
Published: October 2017

Abstract
The phenolphthalein indicator method, the pH of slurries method, X-ray powder diffraction analysis (XRD), and Fourier transform infrared spectroscopy (FTIR) are all commonly associated with evaluating the carbonation front depth in concrete. Recent research (using a closed chamber method) has indicated that stabilized peat is a net sink of carbon dioxide (CO2) (at least in the short term), as the binder takes in CO2 both from the atmosphere and any CO2 released by oxidized peat. Therefore, the application of carbonation depth techniques to stabilized peat are of interest and are explored in this paper for the first time as a precursor to developing a greater understanding of the carbonation process in this material. The carbonation fronts obtained by XRD, loss on ignition, and FTIR all arose at similar depths, as these methods all identify the depth at which the calcium carbonate concentration is elevated with respect to the baseline (i.e., the maximum advancement of the carbonation front). In contrast, the phenolphthalein method underestimated the carbonation front considerably. The pH of the stabilized peat slurries method gave the depth at which leaching of calcium hydroxide and calcium ions occurred, rather than a carbonation depth, and exceeds the depths determined from the other techniques. Advantages and disadvantages of all techniques are discussed.
Simulated Road Profiles According to ISO 8608 in Vibration Analysis
Authors: Múčka P. 
Published: October 2017

Abstract
Nowadays, synthetic longitudinal road profiles based on an ISO 8608 road classification are used for simulation purposes to solve various tasks in vibration analysis of mechanical and civil structures and road-vehicle-driver interaction system. Standard ISO 8608 specifies road classification of longitudinal road profiles based on vertical displacement power spectral density (PSD). PSD represented on logarithmic scales is characterized by two parameters of a straight line, an unevenness index and waviness. The aim of this study was to compare spectrum parameters of real roads with ISO 8608 road classes used in scientific papers. Road classes that were used in a sample of 27 current scientific papers were analyzed. Results often indicated marked differences among road classes used for simulation purposes in comparison to the spectrum properties of real roads. For simulation purposes, road Class A may be recommended as representative of typical good or average quality road (motorway, expressway, and first class road). Classes B and C may be appropriate to simulate low-quality paved surfaces (2nd and 3rd class roads or local highways).
The Prediction of Impact of a Looming Stimulus onto the Body Is Subserved by Multisensory Integration Mechanisms
Authors: Cléry Justine , Guipponi Olivier , Odouard Soline , Pinède Serge , Wardak Claire , Ben Hamed Suliann 
Published: October 2017

In the jungle, survival is highly correlated with the ability to detect and distinguish between an approaching predator and a putative prey. From an ecological perspective, a predator rapidly approaching its prey is a stronger cue for flight than a slowly moving predator. In the present study, we use functional magnetic resonance imaging in the nonhuman primate, to investigate the neural bases of the prediction of an impact to the body by a looming stimulus, i.e., the neural bases of the interaction between a dynamic visual stimulus approaching the body and its expected consequences onto an independent sensory modality, namely, touch. We identify a core cortical network of occipital, parietal, premotor, and prefrontal areas maximally activated by tactile stimulations presented at the predicted time and location of impact of the looming stimulus on the faces compared with the activations observed for spatially or temporally incongruent tactile and dynamic visual cues. These activations reflect both an active integration of visual and tactile information and of spatial and temporal prediction information. The identified cortical network coincides with a well described multisensory visuotactile convergence and integration network suggested to play a key role in the definition of peripersonal space. These observations are discussed in the context of multisensory integration and spatial, temporal prediction and Bayesian causal inference.SIGNIFICANCE STATEMENTLooming stimuli have a particular ecological relevance as they are expected to come into contact with the body, evoking touch or pain sensations and possibly triggering an approach or escape behavior depending on their identity. Here, we identify the nonhuman primate functional network that is maximally activated by tactile stimulations presented at the predicted time and location of impact of the looming stimulus. Our findings suggest that the integration of spatial and temporal predictive cues possibly rely on the same neural mechanisms that are involved in multisensory integration.
The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons
Authors: Larhammar Martin , Huntwork-Rodriguez Sarah , Rudhard York , Sengupta-Ghosh Arundhati , Lewcock Joseph W. 
Published: October 2017

The c-Jun-N-terminal kinase (JNK) signaling pathway regulates nervous system development, axon regeneration, and neuronal degeneration after acute injury or in chronic neurodegenerative disease. Dual leucine zipper kinase (DLK) is required for stress-induced JNK signaling in neurons, yet the factors that initiate DLK/JNK pathway activity remain poorly defined. In the present study, we identify the Ste20 kinases MAP4K4, misshapen-like kinase 1 (MINK1 or MAP4K6) and TNIK Traf2- and Nck-interacting kinase (TNIK or MAP4K7), as upstream regulators of DLK/JNK signaling in neurons. Using a trophic factor withdrawal-based model of neurodegeneration in both male and female embryonic mouse dorsal root ganglion neurons, we show that MAP4K4, MINK1, and TNIK act redundantly to regulate DLK activation and downstream JNK-dependent phosphorylation of c-Jun in response to stress. Targeting MAP4K4, MINK1, and TNIK, but not any of these kinases individually, is sufficient to protect neurons potently from degeneration. Pharmacological inhibition of MAP4Ks blocks stabilization and phosphorylation of DLK within axons and subsequent retrograde translocation of the JNK signaling complex to the nucleus. These results position MAP4Ks as important regulators of the DLK/JNK signaling pathway.SIGNIFICANCE STATEMENTNeuronal degeneration occurs in disparate circumstances: during development to refine neuronal connections, after injury to clear damaged neurons, or pathologically during disease. The dual leucine zipper kinase (DLK)/c-Jun-N-terminal kinase (JNK) pathway represents a conserved regulator of neuronal injury signaling that drives both neurodegeneration and axon regeneration, yet little is known about the factors that initiate DLK activity. Here, we uncover a novel role for a subfamily of MAP4 kinases consisting of MAP4K4, Traf2- and Nck-interacting kinase (TNIK or MAP4K7), and misshapen-like kinase 1 (MINK1 or MAP4K6) in regulating DLK/JNK signaling in neurons. Inhibition of these MAP4Ks blocks stress-induced retrograde JNK signaling and protects from neurodegeneration, suggesting that these kinases may represent attractive therapeutic targets.
About a Key
Authors: Swinkin Jeffrey 
Published: October 2017

In the sonata practice of the mid-eighteenth century, composers frequently asserted the minor dominant prior to the major dominant in the second part of the exposition. Beethoven dramatized this technique in two senses: first, he used it after it had largely fallen out of fashion, thus affording it considerable dramatic impact (e.g., Piano Sonatas Ops. 2, no. 2, and no. 3); second, he graduated from using the “wrong” mode to the more radical technique of using the “wrong” key. For instance, for the secondary key of the Piano Sonatas Ops. 31, no. 1, and 53 (“Waldstein”), he substitutes the major mediant for the dominant. These and similar cases result in the deferred arrival of the tonic in the secondary theme of the recapitulation. Consequently, when the tonic belatedly arrives, the listener is more cognizant of it. In this way Beethoven brings the resolution of large-scale tonal dissonance to the fore. I suggest that such a tactic is metamusical—that Beethoven was in a sense writing music about music, about the relationship between a particular piece and the tonal and formal conventions it relies on and also problematizes.
After presenting a number of such metamusical instances, this article traces the stages by which Beethoven “progressed” from the mid-eighteenth-century approach to sonata expositions to his more radical one; it then offers a typology of key-problematizing techniques. It concludes by briefly considering the extent to which these procedures can be squared with Schenkerian theory and its ideal of structural hearing.
Impact of intercurrent illness on calcium homeostasis in children with hypoparathyroidism: a case series
Authors: Chinoy A , Skae M , Babiker A , Kendall D , Mughal M Z , Padidela R 
Published: October 2017

Background
Hypoparathyroidism is characterised by hypocalcaemia, and standard management is with an active vitamin D analogue and adequate oral calcium intake (dietary and/or supplements). Little is described in the literature about the impact of intercurrent illnesses on calcium homeostasis in children with hypoparathyroidism.

Methods
We describe three children with hypoparathyroidism in whom intercurrent illnesses led to hypocalcaemia and escalation of treatment with alfacalcidol (1-hydroxycholecalciferol) and calcium supplements.

Results
Three infants managed with standard treatment for hypoparathyroidism (two with homozygous mutations in GCMB2 gene and one with Sanjad-Sakati syndrome) developed symptomatic hypocalcaemia (two infants developed seizures) following respiratory or gastrointestinal illnesses. Substantial increases in alfacalcidol doses (up to three times their pre-illness doses) and calcium supplementation were required to achieve acceptable serum calcium concentrations. However, following resolution of illness, these children developed an increase in serum calcium and hypercalciuria, necessitating rapid reduction to pre-illness dosages of alfacalcidol and oral calcium supplementation.

Conclusion
Intercurrent illness may precipitate symptomatic hypocalcaemia in children with hypoparathyroidism, necessitating increase in dosages of alfacalcidol and calcium supplements. Close monitoring is required on resolution of the intercurrent illness, with timely reduction of dosages of active analogues of vitamin D and calcium supplements to prevent hypercalcaemia, hypercalciuria and nephrocalcinosis.
Targeting either GH or IGF-I during somatostatin analogue treatment in patients with acromegaly: a randomized multicentre study
Authors: Dal Jakob , Klose Marianne , Heck Ansgar , Andersen Marianne , Kistorp Caroline , Nielsen Eigil H , Bollerslev Jens , Feldt-Rasmussen Ulla , Jørgensen Jens O L 
Published: October 2017

Context
Discordant GH and IGF-I values are frequent in acromegaly. The clinical significance and its dependence on treatment modality and of glucose-suppressed GH (GHnadir) measurements remain uncertain.

Objective
To evaluate the effects of targeting either IGF-I or GH during somatostatin analogue (SA) treatment.

Patients and Methods
84 patients with controlled acromegaly after surgery (n = 23) or SA (n = 61) underwent a GH profile including an OGTT, at baseline and after 12 months. SA patients were randomized to monitoring according to either IGF-I (n = 33) or GHnadir (n = 28). SA dose escalation was allowed at baseline and 6 months.

Main outcome measures
GHnadir and IGF-I at baseline and 12 months, and disease-specific Quality of Life (QoL).

Results
IGF-I and fasting GH levels were comparable between the surgery and the SA group, whereas GHnadir (µg/L) was lower in the surgery group (GHnadir 0.7 ± 0.1 vs 0.3 ± 0.1, P < 0.01). SA dose increase was performed in 20 patients in the GH group and in 8 patients in the IGF-I group (P = 0.02), which increased the number of concordantly controlled patients (P = 0.01). QoL was only mildly affected at baseline in all groups and did not changed consistently during the study.

Conclusion
(1) Discordant values in terms of high GH levels are prevalent in SA patients and more so if applying glucose-suppressed GHnadir; (2) targeting discordant levels of either GH or IGF-I translates into SA dose increase and improved biochemical control; (3) even though QoL was not improved in this study, we suggest biochemical assessment of disease activity to include glucose-suppressed GHnadir also in SA patients.
Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity
Authors: Hagopian William , Lee Hye-Seung , Liu Edwin , Rewers Marian , She Jin-Xiong , Ziegler Anette-G. , Lernmark Åke , Toppari Jorma , Rich Stephen S. , Krischer Jeffrey P. , Erlich Henry , Akolkar Beena , Agardh Daniel ,   the TEDDY Study Group
Published: October 2017

BACKGROUND AND OBJECTIVES:Few birth cohorts have prospectively followed development of type 1 diabetes (T1D) and celiac disease (CD) autoimmunities to determine timing, extent of co-occurrence, and associated genetic and demographic factors.METHODS:In this prospective birth cohort study, 8676 children at high genetic risk of both diseases were enrolled and 5891 analyzed in median follow-up of 66 months. Along with demographic factors and HLA-DR-DQ, genotypes for HLA-DPB1 and 5 non-HLA loci conferring risk of both T1D and CD were analyzed.RESULTS:Development of persistent islet autoantibodies (IAs) and tissue transglutaminase autoantibodies (tTGAs), as well as each clinical disease, was evaluated quarterly from 3 to 48 months of age and semiannually thereafter. IAs alone appeared in 367, tTGAs alone in 808, and both in 90 children. Co-occurrence significantly exceeded the expected rate. IAs usually, but not always, appeared earlier than tTGAs. IAs preceding tTGAs was associated with increasing risk of tTGAs (hazard ratio [HR]: 1.48; 95% confidence interval [CI]: 1.15–1.91). After adjusting for country, sex, family history, and all other genetic loci, significantly greater co-occurrence was observed in children with a T1D family history (HR: 2.80), HLA-DR3/4 (HR: 1.94) and single-nucleotide polymorphism rs3184504 at SH2B3 (HR: 1.53). However, observed co-occurrence was not fully accounted for by all analyzed factors.CONCLUSIONS:In early childhood, T1D autoimmunity usually precedes CD autoimmunity. Preceding IAs significantly increases the risk of subsequent tTGAs. Co-occurrence is greater than explained by demographic factors and extensive genetic risk loci, indicating that shared environmental or pathophysiological mechanisms may contribute to the increased risk.