bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial work environment in Swedish primary healthcare: a cross-sectional survey of physicians’ job satisfaction, turnover intention, social support, leadership climate and change fatigue
Authors: Fernemark Hanna , Karlsson Nadine , Skagerström Janna , Seing Ida , Karlsson Elin , Brulin Emma , Nilsen Per 
Published: October 2024

Abstract
Background
Primary healthcare, the first line of care in many countries, treats patients with diverse health problems. High workload, time pressure, poor job control and negative interpersonal experiences with supervisors have been documented in primary healthcare. The work environment in primary healthcare is also affected by several types of changes.

Aim
We aimed to explore the levels of job satisfaction, turnover intention, social support, leadership climate and change fatigue according to physicians in Swedish primary healthcare. We also aimed to identify and characterize physicians exhibiting both high turnover intention and low job satisfaction, i.e., “discontent with current job”.

Methods
A cross-sectional survey based on a random sample of physicians working in Swedish primary healthcare.

Results
Approximately one-quarter of the respondents were discontented with their current job. Discontent was negatively associated with poor general health and change fatigue among the respondents; social support from colleagues and a favorable leadership climate showed positive associations in terms of reducing the levels of discontent with current job.

Conclusions
The findings of this study highlight the association between low levels of job satisfaction and high levels of turnover intention (i.e., discontent with current job) among physicians in primary healthcare. Moreover, these variables exhibited a strong association with physicians’ general health; poor health significantly increased the likelihood of discontent with current job. Our findings also show that experiencing change fatigue is associated with discontent with current job among physicians in primary healthcare. This knowledge can help identify and improve shortcomings within the psychosocial work environment in Swedish primary healthcare.
Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke
Authors: Long Erin , Rider Christopher F. , Carlsten Christopher 
Published: October 2024

AbstractOne of the most pressing issues in global health is air pollution. Emissions from traffic-related air pollution and biomass burning are two of the most common sources of air pollution. Diesel exhaust (DE) and wood smoke (WS) have been used as models of these pollutant sources in controlled human exposure (CHE) experiments. The aim of this review was to compare the health effects of DE and WS using results obtained from CHE studies. A total of 119 CHE-DE publications and 25 CHE-WS publications were identified for review. CHE studies of DE generally involved shorter exposure durations and lower particulate matter concentrations, and demonstrated more potent dysfunctional outcomes than CHE studies of WS. In the airways, DE induces neutrophilic inflammation and increases airway hyperresponsiveness, but the effects of WS are unclear. There is strong evidence that DE provokes systemic oxidative stress and inflammation, but less evidence exists for WS. Exposure to DE was more prothrombotic than WS. DE generally increased cardiovascular dysfunction, but limited evidence is available for WS. Substantial heterogeneity in experimental methodology limited the comparison between studies. In many areas, outcomes of WS exposures tended to trend in similar directions to those of DE, suggesting that the effects of DE exposure may be useful for inferring possible responses to WS. However, several gaps in the literature were identified, predominantly pertaining to elucidating the effects of WS exposure. Future studies should strongly consider performing head-to-head comparisons between DE and WS using a CHE design to determine the differential effects of these exposures.
Review of clinical trials and guidelines for children and youth with mucopolysaccharidosis: outcome selection and measurement
Authors: Howie Alison H. , Tingley Kylie , Inbar-Feigenberg Michal , Mitchell John J. , Angel Kim , Gentle Jenifer , Smith Maureen , Offringa Martin , Butcher Nancy J. , Campeau Philippe M. , Chakraborty Pranesh , Chan Alicia , Fergusson Dean , Mamak Eva , McClelland Peyton , Mercimek-Andrews Saadet , Mhanni Aizeddin , Moazin Zeinab , Rockman-Greenberg Cheryl , Rupar C. Anthony , Skidmore Becky , Stockler Sylvia , Thavorn Kednapa , Wyatt Alexandra , Potter Beth K. ,   INFORM RARE Network
Published: October 2024

Abstract
Background
To inform the development of a core outcome set (COS) for children and youth with mucopolysaccharidoses (MPS), we aimed to identify all outcomes and associated outcome measurement instruments that are reported in recent clinical trials and recommended as measurements in clinical management guidelines.

Methods
To identify English-language clinical trials and guidelines pertaining to MPS published between 2011 and mid-2021, we applied a comprehensive peer-reviewed search strategy to relevant databases and registers on May 16, 2021. Two reviewers independently screened retrieved citations and then full-text articles to determine eligibility for inclusion. From articles meeting inclusion criteria, we extracted details of the study design, population, intervention, and comparator, along with verbatim outcomes and associated outcome measurement instruments. Outcomes were organized into domains within five a priori core areas: life impact, pathophysiological manifestations, growth and development, resource use, and death. We conducted descriptive analyses at the study level, grouping articles arising from the same study.

Results
From 2593 unique citations, 73 articles from 61 unique studies were included in the review, pertaining to all MPS subtypes except for exceptionally rare subtypes. Eighty-four unique outcomes were reported across the studies, 33 (39%) of which were reported by three or fewer studies. Most outcomes (55; 65%) were in the pathophysiological manifestations core area, followed by life impact (17; 20%) and growth and development (10; 12%); one outcome each pertained to resource use and death. The most frequently reported outcomes were general adverse events (45; 74%), immune-related adverse events (39; 64%), and urinary glycosaminoglycans (38; 62%). Substantial variability existed in the reporting of outcome measurement instruments. Some differences in outcome reporting were observed by MPS subtype and publication year.

Discussion
Outcomes reported in clinical trials and guidelines for MPS in children and youth vary considerably and largely focus on pathophysiological manifestations. A COS is needed to standardize the selection and measurement of meaningful outcomes across future studies. We will present the outcomes identified in this review to knowledge users as part of a consensus process to select the most critical outcomes for inclusion in the COS.
Trial Registration The protocol for this study was registered in PROSPERO (CRD42021267531) and in the COMET Database.
G4 & the balanced metric family – a novel approach to solving binary classification problems in medical device validation & verification studies
Authors: Marra Andrew 
Published: October 2024

Abstract
Background
In medical device validation and verification studies, the area under the receiver operating characteristic curve (AUROC) is often used as a primary endpoint despite multiple reports showing its limitations. Hence, researchers are encouraged to consider alternative metrics as primary endpoints. A new metric called G4 is presented, which is the geometric mean of sensitivity, specificity, the positive predictive value, and the negative predictive value. G4 is part of a balanced metric family which includes the Unified Performance Measure (also known as P4) and the Matthews’ Correlation Coefficient (MCC). The purpose of this manuscript is to unveil the benefits of using G4 together with the balanced metric family when analyzing the overall performance of binary classifiers.

Results
Simulated datasets encompassing different prevalence rates of the minority class were analyzed under a multi-reader-multi-case study design. In addition, data from an independently published study that tested the performance of a unique ultrasound artificial intelligence algorithm in the context of breast cancer detection was also considered. Within each dataset, AUROC was reported alongside the balanced metric family for comparison. When the dataset prevalence and bias of the minority class approached 50%, all three balanced metrics provided equivalent interpretations of an AI’s performance. As the prevalence rate increased / decreased and the data became more imbalanced, AUROC tended to overvalue / undervalue the true classifier performance, while the balanced metric family was resistant to such imbalance. Under certain circumstances where data imbalance was strong (minority-class prevalence < 10%), MCC was preferred for standalone assessments while P4 provided a stronger effect size when evaluating between-groups analyses. G4 acted as a middle ground for maximizing both standalone assessments and between-groups analyses.

Conclusions
Use of AUROC as the primary endpoint in binary classification problems provides misleading results as the dataset becomes more imbalanced. This is explicitly noticed when incorporating AUROC in medical device validation and verification studies. G4, P4, and MCC do not share this limitation and paint a more complete picture of a medical device’s performance in a clinical setting. Therefore, researchers are encouraged to explore the balanced metric family when evaluating binary classification problems.
Using data fusion with multiple imputation to correct for misclassification in self-reported exposure: a case-control study of cannabis use and homicide victimization
Authors: Lee Seonghun , Li Guohua , Chihuri Stanford , Yu Yuanzhi , Chen Qixuan 
Published: October 2024

Abstract
Background
Cannabis use has been causally linked to violent behaviors in experimental and case studies, but its association with homicide victimization has not been rigorously assessed through epidemiologic research.

Methods
We performed a case-control analysis using two national data systems. Cases were homicide victims from the National Violent Death Reporting System (NVDRS), and controls were participants from the National Survey on Drug Use and Health (NSDUH). While the NVDRS contained toxicological testing data on cannabis use, the NSDUH only collected self-reported data, and thus the potential misclassification in the self-reported data needed to be corrected. We took a data fusion approach by concatenating the NSDUH with a third data system, the National Roadside Survey of Alcohol and Drug Use by Drivers (NRS), which collected toxicological testing and self-reported data on cannabis use for drivers. The data fusion approach provided multiple imputations (MIs) of toxicological testing results on cannabis use for the participants in the NSDUH, which were then used in the case-control analysis. Bootstrap was used to obtain valid statistical inference.

Results
The analyses revealed that cannabis use was associated with 3.55-fold (95% CI: 2.75–4.35) increased odds of homicide victimization. Alcohol use, being Black, male, aged 21–34 years, and having less than a high school education were also significantly associated with increased odds of homicide victimization.

Conclusions
Cannabis use is a major risk factor for homicide victimization. The data fusion with MI method is useful in integrative data analysis for harmonizing measures between different data sources.
Current trends in the characterization and monitoring of vascular response to cancer therapy
Authors: Shrestha Binita , Stern Noah B , Zhou Annie , Dunn Andrew , Porter Tyrone 
Published: October 2024

AbstractTumor vascular physiology is an important determinant of disease progression as well as the therapeutic outcome of cancer treatment. Angiogenesis or the lack of it provides crucial information about the tumor’s blood supply and therefore can be used as an index for cancer growth and progression. While standalone anti-angiogenic therapy demonstrated limited therapeutic benefits, its combination with chemotherapeutic agents improved the overall survival of cancer patients. This could be attributed to the effect of vascular normalization, a dynamic process that temporarily reverts abnormal vasculature to the normal phenotype maximizing the delivery and intratumor distribution of chemotherapeutic agents. Longitudinal monitoring of vascular changes following antiangiogenic therapy can indicate an optimal window for drug administration and estimate the potential outcome of treatment. This review primarily focuses on the status of various imaging modalities used for the longitudinal characterization of vascular changes before and after anti-angiogenic therapies and their clinical prospects.
Migration agencies’ visual performance within the Border spectacle. The case of EU and Canadian institutions
Authors: Massari Alice 
Published: October 2024

AbstractAs images of international mobility circulate quickly and widely through digital and social media, they form a fundamental part of the discursive formations around border policies and material migration practices. Through a multi-modal visual analysis of the Twitter images accompanying the post of the four major migration institutions in the EU and Canada, this article explores in a comparative perspective how their visual narratives interact with the broader migration narrative across the two contexts. The study findings show that EUAA, FRONTEX, CBSA, and IRCC participate in the border spectacle as leading actors, and their visual communication while allows them to reinforce some of their respective migration governance key messages and display their multiple organizational identities at the same time enables the concealment of some of the critical themes of the EU and Canada migration governance.
Tirzepatide Improves Early Dumping Syndrome and Glucose Nadir in Postbariatric Hypoglycemia After Sleeve Gastrectomy
Authors: Stortz Ethan , Lawler Helen 
Published: October 2024

Abstract
Early dumping syndrome (DS) and postbariatric hypoglycemia (PBH) are challenging conditions with limited treatment options. A 46-year-old woman with prediabetes, obesity, and sleeve gastrectomy presented with digestive symptoms suggestive of DS and postprandial hypoglycemia consistent with PBH. She started tirzepatide 2.5 mg weekly, which decreased postprandial blood glucose peaks, increased postprandial blood glucose nadirs, and improved overall time in range on continuous glucose monitoring (CGM). Her postprandial bloating and diarrhea resolved. To our knowledge, there have been no reported cases of DS or PBH treated with dual-incretin agonists. While glucagon-like peptide-1 (GLP-1) agonists have not been widely attempted in DS and have shown mixed benefit for PBH, combination GLP-1 and gastric inhibitory peptide agonism may represent a novel treatment both for PBH and DS, providing greater improvement in glycemic variation as well as better DS control than GLP-1 agonism alone.
Acolhimento de estudantes refugiados no ensino superior por meio do acompanhamento terapêutico: uma aprendizagem das “co-moções”.
Authors: Ferreira Luz Suellen , Lages e Silva Rodrigo 
Published: October 2024

Apresentamos resultados de uma pesquisa que foi realizada a partir do acolhimento educacional de estudantes em situação de refúgio no ensino superior em uma Instituição Federal de Ensino durante o período pandêmico. Para tanto, foi realizada uma aproximação entre os temas de saúde mental e educação, tendo em vista que saúde e aprendizagem se tornaram indissociáveis nos processos de acolhimento. A metodologia se caracterizou como pesquisa-intervenção e teve como dispositivo o do Acompanhamento Terapêutico (AT), por meio do qual foi constituída uma prática clínica porosa, composta pela polifonia de vozes que emergiu no encontro com os estudantes. Centramos nosso debate no conceito de “co-moções” como pista ética por meio da qual se buscou transversalizar saúde mental e educação na direção de um bem-estar pensado como responsabilização pela vida comum. Na discussão de resultados destacamos a percepção contra-etnográfica do encontro com estudantes refugiados e a noção polifonia que emergiu dessa experiência.
Optimization of conditions for excitation of Xe laser plasma in an extreme ultraviolet radiation source for nanolithography in order to increase its efficiency
Authors: Butorin Pavel S. , Kalmykov Serguei G. 
Published: October 2024

Subject of study. The study focuses on laser plasma excited by a Xe gas-jet target. Aim of study. The aim of this study is to increase the output of extreme ultraviolet radiation from such a plasma to a level that meets the requirements of industrial production, specifically for use as a radiation source in a new branch of lithography with a wavelength near 11.2 nm. Method. The primary method used involves changing the diameter of the laser beam by moving a Xe gas-jet target along its axis. This adjustment leads to a change in the interaction area between the beam and the target, which in turn alters the size of the laser spark. The intensity of plasma radiation at wavelengths of 11.2 nm and 13.5 nm was measured using a surface-barrier Si photosensor and a Bragg mirror. Additionally, the energy of the laser radiation absorbed by the plasma was measured. Main results. The results show that, when the diameter of the laser beam illuminating the target increases from 46 µm to 344 µm, the energy emitted in the extreme ultraviolet range increases by approximately 5 times. In the identified irradiation mode, the efficiency of converting laser radiation into radiation with a wavelength of 11.2 nm was 3.9%. Recent measurements of the plasma lifetime have shown that it depends on the size of the plasma and, in several experiments, is significantly shorter than the laser pulse duration. This finding suggests that the plasma lifetime can be used as an optimization parameter when selecting the laser pulse duration. Practical significance. A record-high efficiency is obtained for the conversion of laser pulse energy into extreme ultraviolet radiation by a laser-plasma radiation source with a gas target. This achievement opens up the prospect of using such sources in the industrial production of microcircuits.
Photonics-assisted self-interference cancellation for in-band full-duplex integrated sensing and communication transceiver
Authors: Yu Xiao , Ye Jia , Yan Lianshan , Zhou Tao , Zhong Ningyuan , Zhu Yue , Zou Xihua , Pan Wei 
Published: October 2024

In-band full-duplex (IBFD) operation is essential for both sensing-centric and communication-centric integrated sensing and communications (ISAC) systems. Both types require the monostatic transceiver to overcome the technical challenge of self-interference (SI). To address this challenge, a photonics-assisted self-interference cancellation (SIC) scheme for an IBFD ISAC transceiver is proposed and experimentally demonstrated. By utilizing wavelength division multiplexing, the SI is cancelled by a cancellation reference with matched amplitude and time delay, using two counter-biased Mach-Zehnder modulators. In proof-of-concept experiments, the proposed IBFD ISAC transceiver is tested using a 10 GHz quadrature amplitude modulation (QAM) constant envelope linear frequency modulation orthogonal frequency division multiplexing (CE-LFM-OFDM) ISAC signal with a carrier frequency and a bandwidth of 10 GHz and 2 GHz, respectively. Experimental results show that cancellation depths of 35.29 dB and 32.59 dB are achieved with bandwidths of 1 GHz and 2 GHz, respectively, in the communication receiver. The corresponding weak signal of interest is successfully recovered after effective SIC in the wireless link. The ranging and imaging functions are also experimentally verified. The experimental results show that the cancellation depth of the SI after de-chirping is 23.6 dB when the center frequency and bandwidth of the CE-LFM-OFDM RF signal are 10 GHz and 2 GHz, respectively. A dynamic range increase of 23.84 dB is achieved in imaging function. The corresponding radar ranging resolution of 10 cm is also achieved for radar function. The proposed scheme cancels the SI in both communication and radar receivers, demonstrating excellent performance in the IBFD ISAC transceiver system.
Daily high-frequency transcranial random noise stimulation (hf-tRNS) for sleep disturbances and cognitive dysfunction in patients with mild vascular cognitive impairments: A study protocol for a pilot randomized controlled trial
Authors: Gong Yuqi , Li Jing , Yuen Yuk Shan , Yang Natalie Shu , Li Zeyan , Tang Wai Kwong , Lu Hanna 
Published: October 2024

Background
Poor sleep quality is increasingly considered to be an underlying cause of cerebrovascular diseases. This is a slowly progressing condition that gradually leads to vascular cognitive impairment and stroke during ageing. At present, randomized clinical trials examining the non-pharmacological therapies in the management of this comorbidity are very limited. Transcranial current stimulation (tCS) is a non-invasive technology for promoting cognitive function and treating brain disorders. As advanced modalities of tCS, transcranial random noise stimulation (tRNS) and transcranial alternating current stimulation (tACS), could deliver frequency-specific waveforms of currents that can modulate brain activities in a more specific manner.

Methods and design
Chinese individuals between the ages of 60 and 90 years, who are right-handed and have mild vascular cognitive impairment (VCI) with sleep disturbances, will participate in a randomized study. They will undergo a 2-week intervention period where they will be randomly assigned to one of three groups: high-frequency (hf)-tRNS, 40 Hz tACS, or sham tCS. Each group will consist of 15 participants. Before the intervention, high-resolution magnetic resonance imaging (MRI) data will be used to create a computational head model for each participant. This will help identify the treatment target of left inferior parietal lobe (IPL). Throughout the study, comprehensive assessments will be conducted at multiple time points, including baseline, 2nd week, 6th week, and 12th week. These assessments will evaluate various factors such as sleep quality, domain-specific cognitive performance, and actigraphic records. In addition, the participants’ adherence to the program and any potential adverse effects will be closely monitored throughout the duration of the intervention.

Conclusions
The primary objective of this study is to examine the safety, feasibility, and effectiveness of hf-tRNS and 40 Hz tACS interventions targeting left IPL in individuals with mild vascular cognitive impairment (VCI) who experience sleep disturbances and cognitive dysfunction. Additionally, the study seeks to evaluate the program’s adherence, tolerability, and any potential adverse effects associated with frequency-specific transcranial current stimulation (tCS). The findings from this research will contribute to a deeper understanding of the intricate relationship between oscillation, sleep, and cognition. Furthermore, the results will provide valuable insights to guide future investigations in the field of sleep medicine and neurodegenerative diseases.

Trial registration
ClinicalTrials.gov Identifier: NCT06169254.