bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent HOXB13 mutations in the Dutch population do not associate with increased breast cancer risk
Authors: Liu Jingjing , Prager–van der Smissen Wendy J. C. , Schmidt Marjanka K. , Collée J. Margriet , Cornelissen Sten , Lamping Roy , Nieuwlaat Anja , Foekens John A. , Hooning Maartje J. , Verhoef Senno , van den Ouweland Ans M. W. , Hogervorst Frans B. L. , Martens John W. M. , Hollestelle Antoinette 
Published: July 2016

AbstractThe HOXB13 p.G84E mutation has been firmly established as a prostate cancer susceptibility allele. Although HOXB13 also plays a role in breast tumor progression, the association of HOXB13 p.G84E with breast cancer risk is less evident. Therefore, we comprehensively interrogated the entire HOXB13 coding sequence for mutations in 1,250 non-BRCA1/2 familial breast cancer cases and 800 controls. We identified two predicted deleterious missense mutations, p.G84E and p.R217C, that were recurrent among breast cancer cases and further evaluated their association with breast cancer risk in a larger study. Taken together, 4,520 familial non-BRCA1/2 breast cancer cases and 3,127 controls were genotyped including the cases and controls of the whole gene screen. The concordance rate for the genotyping assays compared with Sanger sequencing was 100%. The prostate cancer risk allele p.G84E was identified in 18 (0.56%) of 3,187 cases and 16 (0.70%) of 2,300 controls (OR = 0.81, 95% CI = 0.41–1.59, P = 0.54). Additionally, p.R217C was identified in 10 (0.31%) of 3,208 cases and 2 (0.087%) of 2,288 controls (OR = 3.57, 95% CI = 0.76–33.57, P = 0.14). These results imply that none of the recurrent HOXB13 mutations in the Dutch population are associated with breast cancer risk, although it may be worthwhile to evaluate p.R217C in a larger study.
Identification and functional analysis of endogenous nitric oxide in a filamentous fungus
Authors: Pengkit Anchalee , Jeon Seong Sil , Son Soo Ji , Shin Jae Ho , Baik Ku Yeon , Choi Eun Ha , Park Gyungsoon 
Published: July 2016

AbstractIn spite of its prevalence in animals and plants, endogenous nitric oxide (NO) has been rarely reported in fungi. We present here our observations on production of intracellular NO and its possible roles during development of Neurospora crassa, a model filamentous fungus. Intracellular NO was detected in hypha 8–16 hours after incubation in Vogel’s minimal liquid media and conidiophores during conidiation using a fluorescent indicator (DAF-FM diacetate). Treatment with cPTIO, an NO scavenger, significantly reduced fluorescence levels and hindered hyphal growth in liquid media and conidiation, whereas exogenous NO enhanced hyphal extension on VM agar media and conidia formation. NO scavenging also dramatically diminished transcription of con-10 and con-13, genes preferentially expressed during conidiation. Our results suggest that intracellular NO is generated in young hypha growing in submerged culture and during conidia development and regulate mycelial development and conidia formation.
Das praktische Vorgehen beim postoperativen und posttraumatischen Lymphödem
Authors: Hirsch T. , Wahl U. 
Published: July 2016

ZusammenfassungSchwellungen der Extremitäten sind nach traumatischen Läsionen häufig zu beobachten und stellen eine differenzialdiagnostische Herausforderung dar. Als Ursache sind neben Seromen bzw. Hämatomen und Thrombosen nicht selten auch lymphostatische Ödeme zu identifizieren, welche unbehandelt einen chronischen Verlauf nehmen. Sie sind charakterisiert durch einen hohen Eiweißanteil und führen langfristig durch fibrotischen Gewebeumbau zu erheblichen Behinderungen und Komplikationen wie rezidivierende Erysipele. Die Diagnosestellung erfolgt i. d. R. klinisch, was die Kenntnis der Symptomatik voraussetzt. Die wichtigste Behandlungsoption stellt die Komplexe Physikalische Entstauung dar. Hierbei kommen manuelle Lymphdrainage und lymphologische Mehrkomponentenverbände in mindestens täglicher Frequenz zur Anwendung. Nur in Einzelfällen sind auch chirurgische Interventionen möglich. Aufgrund ihres chronischen Verlaufs mit möglicher Invalidisierung sind posttraumatische Lymphödeme nicht selten Gegenstand der Begutachtung im Rahmen von Verfahren der gesetzlichen und privaten Unfallversicherung. Die vorliegende Arbeit erläutert die Entstehungsmechanismen posttraumatischer Lymphödeme und bietet eine Übersicht zu differenzialdiagnostischen Methoden und den aktuellen therapeutischen Empfehlungen. Zudem gehen die Autoren auf versicherungsrelevante Aspekte ein.
Conservation law for self-paced movements
Authors: Huh Dongsung , Sejnowski Terrence J. 
Published: July 2016

Significance
Most of our day-to-day movements are carried out spontaneously at a comfortable pace. A leading theory for how movements are generated cannot model such self-paced movements because it requires external factors to determine the pace, such as reward or a deadline to complete a movement. We show that the dual form of this existing theory implies a conserved quantity, called “drive,” that accounts for the regular features in self-paced movements without assuming any external factors. Drive complements the current theory based on external tasks by formalizing the influence of internal motivation on biological motor control.
Représentations localement analytiques de 𝐺𝐿₂(𝐐_{𝐩}) et (𝜑,Γ)-modules
Authors: Colmez Pierre 
Published: July 2016

We extend thepp-adic local Langlands correspondence forGL2(Qp)\textbf {GL}_2(\mathbf {Q}_p)to a correspondenceΔ↦Π(Δ)\Delta \mapsto \Pi (\Delta )between(φ,Γ)(\varphi ,\Gamma )-modules of rank 22over the Robba ring and certain locally analytic representations ofGL2(Qp)\textbf {GL}_2(\mathbf {Q}_p). IfΔ\Deltais isocline, one uses the existing correspondence; in the remaining cases one builds aGL2(Qp)\textbf {GL}_2(\mathbf {Q}_p)-module from parabolically induced locally analytic representations and their duals. This construction extends toGL2(F)\textbf {GL}_2(F)ifFFis a finite extension ofQp\mathbf {Q}_p, which suggests that the same should be true for the correspondenceΔ↦Π(Δ)\Delta \mapsto \Pi (\Delta ).

Résumé.Nous étendons la correspondance de Langlands localepp-adique pourGL2(Qp)\textbf {GL}_2(\mathbf {Q}_p)en une correspondanceΔ↦Π(Δ)\Delta \mapsto \Pi (\Delta )entre les(φ,Γ)(\varphi ,\Gamma )-modules de rang 2 sur l’anneau de Robba et certaines représentations localement analytiques deGL2(Qp)\textbf {GL}_2(\mathbf {Q}_p). SiΔ\Deltaest isocline, on se ramène à la correspondance déjà établie ; dans le cas contraire, on construit unGL2(Qp)\textbf {GL}_2(\mathbf {Q}_p)-module formé d’induites paraboliques localement analytiques et de leurs duales. Cette construction s’étend àGL2(F)\textbf {GL}_2(F), siFFest une extension finie deQp\mathbf {Q}_p, ce qui suggère qu’il en est de même de la correspondanceΔ↦Π(Δ)\Delta \mapsto \Pi (\Delta ).
Specific effect of a dopamine partial agonist on counterfactual learning: evidence from Gilles de la Tourette syndrome
Authors: Salvador Alexandre , Worbe Yulia , Delorme Cécile , Coricelli Giorgio , Gaillard Raphaël , Robbins Trevor W. , Hartmann Andreas , Palminteri Stefano 
Published: July 2016

AbstractThe dopamine partial agonist aripiprazole is increasingly used to treat pathologies for which other antipsychotics are indicated because it displays fewer side effects, such as sedation and depression-like symptoms, than other dopamine receptor antagonists. Previously, we showed that aripiprazole may protect motivational function by preserving reinforcement-related signals used to sustain reward-maximization behaviour in a simple action-outcome learning task. However, the effect of aripiprazole on more cognitive facets of human reinforcement learning, such as learning from the hypothetical outcomes of alternative courses of action (i.e., counterfactual learning), is unknown.To test the influence of aripiprazole on counterfactual learning, we administered a reinforcement-learning task that involves both direct learning from obtained outcomes and indirect learning from forgone outcomes to two groups of Gilles de la Tourette (GTS) patients, one consisting of patients who were completely unmedicated and the other consisting of patients who were receiving aripiprazole monotherapy, and to healthy subjects. We replicated a previous finding showing that aripiprazole does not affect direct learning from obtained outcomes in GTS. We also found that whereas learning performance improved in the presence of counterfactual feedback in both healthy controls and unmedicated GTS patients, this was not the case in aripiprazole-medicated GTS patients.Our results suggest that whereas aripiprazole preserves direct learning of action-outcome associations, it may impair more complex inferential processes, such as counterfactual learning, from forgone outcomes.
The significance of definitional dimensions of luxury food
Authors: Hartmann Laura Helena , Nitzko Sina , Spiller Achim 
Published: July 2016

Purpose
– An observable shift in food consumption motives for some German consumer segments has created new market potentials for high-priced food items. The purpose of this paper is to empirically show whether and to what extent financial, functional, individual and social dimensions as well as sustainability and authenticity contribute to consumers’ perception of the luxury value of food.

Design/methodology/approach
– The effects of seven exploratory value dimensions on a perceived luxury value for foods were measured using a partial least squares structural equation analysis of a database generated by a survey done on 936 German consumers in summer 2014.

Findings
– Luxury food was found to serve as a suitable setting to investigate both old and new motives for luxury consumption. The analyses revealed that all factors contribute significantly to luxury value, with functional and individual luxury facets having the strongest effects. Practical and methodological implications can be derived from the results.

Research limitations/implications
– Limitations are due to the applied methodology.

Practical implications
– The definitional dimensions of a luxury food value correspond to those for a general luxury good. The significance of two new luxury values, sustainability and authenticity, was confirmed for luxury food. The functional and individual luxury values were found to be the most significant. This supports the previously postulated change in motives for luxury consumption and also mirrors the new emphasis on quality and self-identity in the German food sector. These findings can be utilised in practical food marketing.

Originality/value
– Although there are major similarities between food and luxury good consumption patterns, how luxury can be defined in the context of food had not been previously investigated empirically. This paper is the first to study the factors that contribute to the luxury value of food.
Enhanced pretreatment, characterization and utilization of Prosopis juliflora stem for bioethanol production
Authors: Sivarathnakumar S. , Baskar G. , Praveen Kumar R. , Bharathiraja B. 
Published: July 2016

Purpose
–Prosopis juliflora is a raw material for long-term sustainable production of bioethanol. The purpose of this paper is to identify the best combination of pre-treatment strategy implemented on the lignocellulosic biomass Prosopis juliflora for bioethanol production.

Design/methodology/approach
– Pre-treatment of lignocellulosic material was carried out using acid, alkali and sonication in order to characterize the biomass for bioethanol production. Prosopis juliflora stem was subjected to steam at reduce temperature (121°C) for one hour residence time initially. Further acid and alkali treatment was carried out individually followed by combinations of acid and sonication, alkali and sonication. Sodium hydroxide, potassium hydroxide, hydrochloric acid, sulphuric acid and nitric acid were used with 3 per cent (w/v) and 3 per cent (v/v) concentration under temperature range of 60-90°C for 60 min incubation time. Sonication under 60°C for 5 min and 40 KHz frequency was carried out. Pre-treated sample were further characterised using field emission scanning electron microscope and Fourier transform infrared spectroscopy to understand the changes in surface morphology and functional characteristics.

Findings
– In sono assisted acid treatment-based method, nitric acid yields better cellulose content at 70°C and removes lignin that even at increased temperatures no burning was observed.

Originality/value
– The paper adds to the scarce research available on the combination of auto hydrolysis coupled with sono assisted acid/alkali hydrolysis which is yet to be practiced.
A perceptual study of users’ expectations of urban green infrastructure in Kalamaria, municipality of Greece
Authors: Karanikola Paraskevi , Panagopoulos Thomas , Tampakis Stilianos , Karipidou-Kanari Aikaterini 
Published: July 2016

Purpose– The purpose of this paper is to investigate residents’ perceptions, preferences and satisfaction concerning the urban green infrastructure of Kalamaria, Greece, to evaluate the importance of urban parks for residents’ well-being and to suggest management improvements.Design/methodology/approach– Following a random sampling method, 385 residents were interviewed. Green infrastructure number and size, design suitability, safety, variety and care of plants, noise pollution, facilities for people with disabilities and duration and frequency of visits to green areas were among the considered parameters. Factor and hierarchical log-linear analyses were conducted.Findings– The existing green spaces were insufficient in number, size and design, and their distribution was unsatisfactory. The facilities and equipment in the green spaces were evaluated as rather mediocre, and most respondents were unsatisfied with the overall planning and management of the green infrastructure in the municipality of Kalamaria. The results indicate that resident’s well-being relates to their satisfaction with urban green infrastructure. Frequent and longer visits of green spaces significantly improved the perceived well-being. The residents expressed an intention to pay 20-40 percent more than the average price for a house with a view of a green area.Originality/value– Public perception surveys enable green infrastructure managers to identify preferred management alternatives and to use this information in an urban planning framework. Local authorities can use the results of the present survey to manage the city’s green infrastructure, enhance the city’s resilience and anticipate climate change challenges and the future needs of residents.
The research productivity of new Brazilian PhDs in management
Authors: Falaster Christian , Ferreira Manuel Portugal , Serra Fernando Ribeiro 
Published: July 2016

Purpose
Doctoral programs are primarily intended to train new professors and researchers to take positions requiring research competency. This paper aims to observe the scientific production of 734 Brazilian new PhDs in management and the possible link between the scientific output of the graduates and doctoral program rank.

Design/methodology/approach
Methodologically, the authors built a database collecting the journal publications of the first six years after doctoral degree of all PhDs in management graduated by Brazilian doctoral programs during the period of 1998-2008. The authors use cluster and descriptive analysis to explore PhD publication.

Findings
Results show a great disparity of productivity, where 10 per cent of all new PhDs account for most of the Brazilian research productivity, while most of the PhDs have a very low performance – and that the CAPES (the Brazilian institutional system) qualification of doctoral programs is not a good predictor of the performance of the future graduates. Results are discussed to understand this productivity gap among researchers in a context of a developing country where support institutions are working to improve quantity and quality of publication.

Practical implications
The results are useful for recruiters that need to decide between hiring new PhDs with low productivity graduated from high-ranked programs or new PhDs with high productivity from programs with more modest ranking. At least in part, the authors’ results question the real impact that the doctoral program’s prestige has on the performance of its graduates.

Social implications
There are implications for the future candidates to a management PhD program, for the Directors of these programs and for the institutional agencies that regulate and promote science and that establish the prevailing rules and norms that researchers and institutions follow.

Originality/value
The results are adamant in pointing out that there is a small group of highly productive new PhDs – that the authors called “stars”. Generally speaking, they may find these “star” new PhDs in several doctoral programs. They have also found that some of the new PhDs have a relatively higher level of international papers published, but not necessarily a larger volume of publications. Meanwhile, most PhDs present a very low level of performance. This has important contributions to the way they perceive the doctoral education in management, especially in Ibero-America, revealing insights about the quality of PhDs and PhD courses.
Mammalian engineers drive soil microbial communities and ecosystem functions across a disturbance gradient
Authors: Eldridge David J. , Delgado‐Baquerizo Manuel , Woodhouse Jason N. , Neilan Brett A. 
Published: July 2016

Summary

The effects of mammalian ecosystem engineers on soil microbial communities and ecosystem functions in terrestrial ecosystems are poorly known. Disturbance from livestock has been widely reported to reduce soil function, but disturbance by animals that forage in the soil may partially offset these negative effects of livestock, directly and/or indirectly by shifting the composition and diversity of soil microbial communities. Understanding the role of disturbance from livestock and ecosystem engineers in driving soil microbes and functions is essential for formulating sustainable ecosystem management and conservation policies.

We compared soil bacterial community composition and enzyme concentrations within four microsites: foraging pits of two vertebrates, the indigenous short‐beaked echidna (Tachyglossus aculeatus) and the exotic European rabbit (Oryctolagus cuniculus), and surface and subsurface soils along a gradient in grazing‐induced disturbance in an arid woodland.

Microbial community composition varied little across the disturbance gradient, but there were substantial differences among the four microsites. Echidna pits supported a lower relative abundance of Acidobacteria and Cyanobacteria, but a higher relative abundance of Proteobacteria than rabbit pits and surface microsites. Moreover, these microsite differences varied with disturbance. Rabbit pits had a similar profile to the subsoil or the surface soils under moderate and high, but not low disturbance.

Overall, echidna foraging pits had the greatest positive effect on function, assessed as mean enzyme concentrations, but rabbits had the least. The positive effects of echidna foraging on function were indirectly driven via microbial community composition. In particular, increasing activity was positively associated with increasing relative abundance of Proteobacteria, but decreasing Acidobacteria.

Our study suggests that soil disturbance by animals may offset, to some degree, the oft‐reported negative effects of grazing‐induced disturbance on soil function. Further, our results suggest that most of this effect will be derived from echidnas, with little positive effects due to rabbits. Activities that enhance the habitat for echidnas or reduce rabbit populations are likely to have a positive effect on soil function in these systems.
Effects of permafrost thaw on nitrogen availability and plant–soil interactions in a boreal Alaskan lowland
Authors: Finger Rebecca A. , Turetsky Merritt R. , Kielland Knut , Ruess Roger W. , Mack Michelle C. , Euskirchen Eugénie S. 
Published: July 2016

Summary

Increasing rates of permafrost thaw in boreal peatlands are converting conifer forests to waterlogged open wetlands. Permafrost thaw increases soil nitrogen (N) availability, but it is unclear whether such changes are due solely to changes in surface soil N mineralization or N mobilization from thawing permafrost soils at depth.

We examined plant species composition and N availability along triplicate permafrost thaw gradients in Alaskan peatlands. Each gradient comprised four community types including: (i) a permafrost peatland with intact permafrost, (ii) a drunken forest experiencing active thaw, (iii) a moat representing initial complete thaw and (iv) a collapse scar bog representing several decades of post‐thaw succession.

Concentrations of dissolved organic (DON) and inorganic N (DIN) in the upper 60 cm of soil increased along the permafrost thaw gradients. The drunken forest had the greatest mean concentrations of total dissolved N relative to the other community types, primarily due to greater concentrations of large molecular DON. The moat and collapse bog had significantly greater inorganic N concentrations than the permafrost or drunken forest, suggesting that changes in N availability are not a short‐term effect, but can be sustained for decades or centuries. Across all plant community types, DIN and DON concentrations increased with soil depth during maximum seasonal ice thaw (September), suggesting that deeper soil horizons are important reservoirs of N post‐thaw.

Vegetation responses to permafrost thaw included changes in plant community composition shifting from upland forest species to hydrophilic vegetation with deeper rooting profiles in the collapse scar bogs and changes in foliar N and δ15N values. N concentrations in plant foliage and litterfall increased with concentrations of DIN during collapse bog succession, suggesting that plants are utilizing additional mineralized N.

Synthesis. Our results suggest that the conversion of forest to wetlands associated with permafrost thaw in boreal lowlands increases N availability, at least in part by increasing turnover of deep soil organic matter. Plants appear to utilize these additional deeper N sources over timescales of years to centuries following permafrost thaw.
Chronic mercury exposure impairs the sympathovagal control of the rat heart
Authors: Simões MR , Azevedo BF , Fiorim J , Jr Freire DD , Covre EP , Vassallo DV , dos Santos L 
Published: July 2016

SummaryMercury is known to cause harmful neural effects affecting the cardiovascular system. Here, we evaluated the chronic effects of low‐dose mercury exposure on the autonomic control of the cardiovascular system. Wistar rats were treated for 30 days with HgCl2 (1st dose 4.6 μg/kg followed by 0.07 μg/kg per day, intramuscular) or saline. The femoral artery and vein were then cannulated for evaluation of autonomic control of the hemodynamic function, which was evaluated in awake rats. The following tests were performed: baroreflex sensitivity, Von Bezold‐Jarisch reflex, heart rate variability (HRV) and pharmacological blockade with methylatropine and atenolol to test the autonomic tone of the heart. Exposure to HgCl2 for 30 days slightly increased the mean arterial pressure and heart rate (HR). There was a significant reduction in the baroreflex gain of animals exposed to HgCl2. Moreover, haemodynamic responses to the activation of the Von Bezold‐Jarisch reflex were also reduced. The changes in the spectral analysis of HRV suggested a shift in the sympathovagal balance toward a sympathetic predominance after mercury exposure, which was confirmed by autonomic pharmacological blockade in the HgCl2 group. This group also exhibited reduced intrinsic HR after the double block suggesting that the pacemaker activity of the sinus node was also affected. These findings suggested that the autonomic modulation of the heart was significantly altered by chronic mercury exposure, thus reinforcing that even at low concentrations such exposure might be associated with increased cardiovascular risk.