bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Phase III Study of Balugrastim Versus Pegfilgrastim in Breast Cancer Patients Receiving Chemotherapy With Doxorubicin and Docetaxel
Authors: Gladkov Oleg , Moiseyenko Vladimir , Bondarenko Igor N. , Shparyk Yaroslav , Barash Steve , Adar Liat , Avisar Noa 
Published: December 2015

Abstract

Objectives.
This study aimed to evaluate the efficacy and safety of once-per-cycle balugrastim versus pegfilgrastim for neutrophil support in breast cancer patients receiving myelosuppressive chemotherapy.

Methods.
Breast cancer patients (n = 256) were randomized to 40 or 50 mg of subcutaneous balugrastim or 6 mg of pegfilgrastim ≈24 hours after chemotherapy (60 mg/m2 doxorubicin and 75 mg/m2 docetaxel, every 21 days for up to 4 cycles). The primary efficacy parameter was the duration of severe neutropenia (DSN) in cycle 1. Secondary parameters included DSN (cycles 2–4), absolute neutrophil count (ANC) nadir, febrile neutropenia rates, and time to ANC recovery (cycles 1–4). Safety, pharmacokinetics, and immunogenicity were assessed.

Results.
Mean cycle 1 DSN was 1.0 day with 40 mg of balugrastim, 1.3 with 50 mg of balugrastim, and 1.2 with pegfilgrastim (upper limit of 95% confidence intervals for between-group DSN differences was &lt;1.0 day for both balugrastim doses versus pegfilgrastim). Between-group efficacy parameters were comparable except for time to ANC recovery in cycle 1 (40 mg of balugrastim, 2.0 days; 50 mg of balugrastim, 2.1; pegfilgrastim, 2.6). Median terminal elimination half-life was ≈37 hours for 40 mg of balugrastim, ≈36 for 50 mg of balugrastim, and ≈45 for pegfilgrastim. Antibody response to balugrastim was low and transient, with no neutralizing effect.

Conclusion.
Once-per-cycle balugrastim is not inferior to pegfilgrastim in reducing cycle 1 DSN in breast cancer patients receiving chemotherapy; both drugs have comparable safety profiles.
Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis
Authors: Cordel Nadège , Tressières Benoît , D'Incan Michel , Machet Laurent , Grange Florent , Estève Éric , Dalac Sophie , Ingen-Housz-Oro Saskia , Bagot Martine , Beylot-Barry Marie , Joly Pascal ,   French Study Group on Cutaneous Lymphoma
Published: December 2015

Abstract

Background.
Lymphomatoid papulosis (LyP) is classified as an indolent cutaneous lymphoma, but outcome dramatically worsens if LyP is associated with lymphoma. The frequency of this association remains unclear in the literature. Here, we assess the frequency and risk factors of association between LyP and another lymphoma in an 11-year retrospective study conducted in 8 dermatology departments belonging to the French Study Group on Cutaneous Lymphoma (FSGCL).

Patients and Methods.
Patients with LyP were identified and data extracted from the FSGCL registry between 1991 and 2006. Patients were followed up to January 2014. Age, sex, number of skin lesions, histologic subtype, and genotype were recorded at baseline. Risk factors were determined using univariate and multivariate analysis. Cumulative probability of association was calculated using the Kaplan-Meier method.

Results.
We observed 52 cases of lymphomas (cutaneous, n = 38; systemic, n = 14) in 44 of 106 patients (41%). Lymphoma diagnosis was concomitant with or prior to LyP diagnosis in 31 cases and occurred during the course of LyP in 21 cases (cutaneous, n = 14; systemic, n = 7; median delay: 5 years; interquartile range: 1.5–7 years). In multivariate analysis, main prognostic factors for association between LyP and another lymphoma were older age (odds ratio [OR]: 1.05 per year; 95% confidence interval [CI]: 1.01–1.08; p = .011) and presence of a T-cell clone in LyP lesions (OR: 7.55; 95% CI: 2.18–26.18; p = .001).

Conclusion.
Older age and presence of a T-cell clone in LyP lesions are risk factors for associated lymphomas in patients with LyP. These findings should help to identify patients who require close management in clinical practice.
The Effect of Introducing the Spinal Instability Neoplastic Score in Routine Clinical Practice for Patients With Spinal Metastases
Authors: Versteeg Anne L. , Velden Joanne M. , Verkooijen Helena M. , Vulpen Marco , Oner F. Cumhur , Fisher Charles G. , Verlaan Jorrit-Jan 
Published: December 2015

Abstract

Background.
Stable spinal metastases are effectively treated with radiotherapy, whereas unstable spinal metastases often need surgical fixation followed by radiotherapy for local control. The Spinal Instability Neoplastic Score (SINS) was developed as a tool to assess spinal neoplastic related instability with the goal of helping to guide referrals among oncology specialists. We compare the average degree of spinal instability between patients with spinal metastases referred for surgery or for radiotherapy and evaluate whether this difference changed after introduction of the SINS in clinical practice.

Methods.
All patients with spinal metastases treated with palliative surgery or radiotherapy in the period 2009–2013 were identified in two spine centers. For all patients, the SINS was scored on pretreatment imaging. The SINS before and after introduction of the SINS in 2011 were compared within the surgical and radiotherapy group. Furthermore, the overall SINS was compared between the two groups.

Results.
The overall SINS was significantly higher in the surgical group, with a mean SINS of 10.7 (median 11) versus 7.2 (median 8) for the radiotherapy group. The mean SINS decreased significantly for both groups after introduction of the SINS in clinical practice from 11.2 to 10.3 in the surgical group and from 8.4 to 7.2 in the radiotherapy group.

Conclusion.
The SINS differed significantly between patients treated with surgery or radiotherapy. The introduction of SINS led to a decrease in SINS score for both groups, suggesting that using SINS in metastatic spinal disease increases awareness for instability and may subsequently result in earlier referrals for surgical intervention.
THE PRESENCE OF BIOCHEMISTRY EXPERIMENTS IN TEXTBOOKS
Authors: Rocha C. E.S. , Büttenbender M. D. , Roehrs R. 
Published: December 2015

INTRODUCTION: Being present in high school in chemistry and biology disciplines, biochemistry is to explain the chemical and biological reactions in cells. His concepts are seen as abstract and difficult to understand and can be contextualized through experimentation. Experimentation is used in the classroom to allow students to view the applicability of the contents through observation, creating hypotheses, discussion and conclusions. OBJECTIVES: The aim of this study was to evaluate the presence of experimentation in biochemistry content in high school books. MATERIALS AND METHODS: In this way, it was analyzed the presence of experimental activities in the textbooks approved by the National Textbook Plan 2015 "Biology 1", authored by César da Silva Junior, Sezar Sasson and Nelson Caldini Junior, and in the book " Chemistry - Volume 3 "by Martha Reis. RESULTS: At the end of the unit where the biochemical concepts are covered in the book "Biology 1" is presented an interdisciplinary project called "Enzymes - chemical tools of life" that proposes four experiments on catalase, pH and contact surface enzyme-substrate. They are easy activities to be implemented with affordable materials. Already at the Chemistry book, when addressing the biochemistry there is only one proposal for experimental activity called "Glycolic Extract of milk proteins". In this case, we need materials like food processor and enameled pots, which can hinder your performance in virtual classes, however, the experiment is easy to perform. Both books contain questions after the experimental proposals enhancing the questioning of the activities and understanding the contents addressed. CONCLUSIONS: The present experimental activities in the textbooks are mostly easy to apply and is not required sophisticated equipment of Sciences laboratories. It also allows the contextualization of theory and practice enhancing the process of teaching and learning with the proposals made.
A proposal of collaborative education for biochemistry and cell biology teaching
Authors: Souza-Júnior A. A. , Silva A. P. , Silva T. A. , Andrade G. P.V. 
Published: December 2015

INTRODUCTION: Currently students grow up in a world of digital tools that allow you to connect instantly with the world. At the same time, teachers face several challenges to increase student interest and learning efficiency. One such challenge is the pedagogical commitment of the density of biochemistry and cell biology contents, producing a conflict scenario, between meeting content and maintain the class quality. OBJECTIVES: From this perspective, this study aimed to evaluate the learning biochemistry and cell biology contents in high school classes of IFRN, using collaborative and digital tools in the Moodle. MATERIAL AND METHODS: The contents were offered using various tools such as video lectures, forums, questionnaires, portfolios, glossaries and electronic books. Then these tools were evaluated using an electronic form. In addition to the tools, we evaluated the platform interaction, the performance of activities and the content gamification. RESULTS: The quantitative results revealed directly proportional relationship of the interaction of Moodle with the performance of activities. The content gamification was also assessed positively, with 61% of students considered good, very good or excellent. The best evaluated tools were video lectures, with 31% preference, and questionnaires, with 24%; followed by electronic book, with 10%, and portfolio, with 5.5%. The other tools totaled 30% of the preference. Qualitative results revealed an educational gain of content, because the student lived the experience of teaching and learning collaboratively. In addition, these tools decreased conflicts between content and schedule. CONCLUSION: Thus, the use of information and communication technology (ICT) in a collaborative learning provides relevant results, bringing the reality of the world connected to the classroom. In addition, it assists in defining the content and creative development of a strategy for the construction of the concepts applied to biochemistry and cell biology teaching.
A DIGITAL TOOL FOR CASEIN ISOLECTRIC POINT DETERMINATION
Authors: Trindade V. M.T. , Santos I. B. , Zanatta G. , Arantes P. R. , Salbego C. G. 
Published: December 2015

Introduction: Casein is a milk protein that has the same number of positive and negative charges in a pH around 4.7. This characteristic is called the isoelectric point (pI). The pI varies from protein to protein and it depends on the charges of the lateral chain of the constituent aminoacids. At this pH value the protein has its minimum solubility since the net charge is zero and the repulsion between molecules is decreased. Furthermore, the electrostatic interaction occurs between the protein molecules. Thus, they form clumps which tend to precipitate. On the other hand, when they are placed in a solution whose pH is above or below of its pI, the protein molecules have respectively a negative or positive net charge, with strong repulsion between themselves and great interaction with the solvent (water). Objective: This learning object presents a simulation of a laboratory practice for the determination of casein isoelectric point. Materials and Methods: Cartoons were planned in order to show the methodology procedures and biochemical fundamentals. Animations were developed with the aid of the Adobe ® Flash 8 software associated with logic programming. Results: The simulation consists of six steps that reproduce the activities performed in the laboratory. Among them, the user can observe different degrees of turbidity and / or precipitation of casein in solutions with different pH values, he can measure these values with paper indicator strips and then determine the pI of this protein. Conclusions: This learning object was tested by students of Biochemistry I, Pharmacy course since 2012/2. The navigation features, design, interaction, interactivity were considered excellent by 80% of students indicating that this object can be used as an interesting tool to assist the teaching and learning of basic biochemistry. Available at:www.ufrgs.br/gcoeb/PontoIsoleletricoDaCaseina/PontoIsoleletricoDaCaseina.swf
NEW MATERIALS FOR PEDAGOGICAL TEACHING-LEARNING IN BIOCHEMISTRY: MONITORING PARTICIPATION
Authors: Campos R. S. , Fernandes I. L. , Andrade G. P.V. , Matta L. D.M. , Filgueira L. G.A. 
Published: December 2015

This summary consists of an experience report about actions taken by biochemical monitors with pharmacy students. The reason of our work was the intention to both improve the process of teaching and also learning and invalidate the labels owned by biochemistry of hard and high-level-failure subject. The three actors: teachers, students and monitor could act on an integrated basis for the construction of an articulated pedagogical process between theory/practice and learning signification. Our main objective was to initiate the monitors in teaching practice effected through educational projects aimed at improving the teaching and learning of undergraduate courses and encouraging teacher training, involving teachers and students the guiding condition and monitors, respectively. The methodology was applied in three stages: 1) preparation of teaching materials; 2nd) application in class and 3rd) students rating of the methodology applied by monitors. The teaching materials presented discussed several biochemistry's topics and students had the opportunity to scaffold their own knowledge actively. Almost 90% considered the tool applied as highly related to classes and 82% considered this way of learning more significant than dialogical lectures. The performance of the monitors, focused on students and their learning, was considered great by students who were more motivated, resulting in the excellent evaluation of the work (100% of acceptance). The failure rate of the subject reduced in the four groups wherein the pedagogical materials were applied. It can demonstrate that both the mastery of scientific content and the pedagogical process involved during the teaching and learning moments are important.
AVALIAÇÃO DO DISCO INTERVERTEBRAL DE RATOS WISTAR APÓS USO DE EXPERIMENTAL SUIT THERAPY
Authors: Mattjie Thiago Fernando , Rosa Camila Thieime , Borges Márcia Cristina Dias , Brancalhão Rose Meire Costa , Ribeiro Lucinéia De Fátima Chasko , Bertolini Gladson Ricardo Flor 
Published: December 2015

Objetivos: visto que a sobrecarga ou pressão inadequada sobre as estruturas do disco intervertebral podem causar degeneração discal, este estudo teve como objetivo, avaliar um modelo experimental da suit therapy sobre os discos intervertebrais do segmento torácico da coluna, avaliando a altura na sua porção anterior, medial e posterior, como também da altura do núcleo pulposo. Métodos: 30 ratos Wistar, foram separados em 5 grupos (G1 – controle; G2 – simulação do uso da suit; G3 – 2 horas com a suit; G4 –2 horas com peso adaptado; G5 – 2 horas com a vestimenta e bandas de tração). Foi confeccionado um modelo experimental da vestimenta, tipo macacão terapêutico. O experimento teve duração de 4 semanas, com a colocação da vestimenta em 5 dias consecutivos, com pausa de 2 dias. Ao final o segmento torácico da coluna vertebral foi dissecado na região do cruzamento das bandas elásticas, entre T7 e T10. Os segmentos foram fixados em formol, clivados longitudinalmente, no plano mediano, tendo como base os processos espinhosos, seccionados em espessura de 7 μm, e corados em Hematoxilina Eosina (HE). As imagens foram obtidas por fotomicrografia e analisadas as alturas nas regiões anterior, média e posterior do disco, e ainda, a altura do núcleo pulposo. Resultados: não houve diferença significativa, na mensuração das alturas avaliadas. Conclusão: Conforme o protocolo, de compressão do disco, apresentado não houve alterações morfométricas do disco intervertebral torácico de ratos Wistar.
ANÁLISE DA QUALIDADE DE VIDA E DISTÚRBIOS OSTEOMUSCULARES DOS FUNCIONÁRIOS ADMINISTRATIVOS DE UM ÓRGÃO PÚBLICO
Authors: Souza Kleber Veríssimo Leão , Gomes Neto Mansueto 
Published: December 2015

Contextualização: Trabalhadores que exercem atividades administrativas constituem uma população que está diretamente exposta ao risco ergonômico, estando sujeitos ao aparecimento de distúrbios osteomusculares e comprometimento da sua qualidade de vida (QV). Objetivos: Analisar a QV e os distúrbios osteomusculares de funcionários administrativos de um órgão público e verificar se os possíveis distúrbios osteomusculares foram capazes de influenciar na QV dos mesmos. Métodos: Foram coletadas informações sociodemográficas e ocupacionais, além de dados dos Questionários SF-36 - Medical Outcomes Study 36 e Nórdico de Sintomas Osteomusculares (QNSO), que foram analisados com o uso do software SPSS® (Statistical Package for the Social Sciences) for Windows (versão 14.0). Resultados: A amostra foi composta de 100 indivíduos com média de idade de 38 ± 11,6 anos, predominando sexo feminino (76%), solteiros (55%) e com escolaridade média (47%). A Limitação por Aspectos Físicos apresentou a maior pontuação, Dor e Vitalidade as menores pontuações no SF-36. Todos relataram alterações osteomusculares em ao menos uma região, onde a maior parte indicou o punho/mão/dedo (62%) como o segmento corporal mais atingido pelos sintomas osteomusculares nos últimos 12 meses, seguido pelo ombro (59%), pela lombar (57%) e pelo pescoço (56%), respectivamente. Conclusão: Apesar da alta frequência de distúrbios osteomusculares, a QV não foi negativamente afetada, sugerindo que outros fatores são necessários para esse comprometimento.
ANÁLISE DA CIRCULAÇÃO URBANA NA AV. JOÃO PESSOA, CIDADE DE GUARATINGUETÁ E PROPOSTA DE INTERVENÇÃO
Authors: Silva Enos Arneiro Nogueira da , Moura André Luiz Cândido de 
Published: December 2015

RESUMO Este trabalho foi realizado com intuito de aprofundar os estudos sobre a cultura do automóvel nas cidades brasileiras. Teve como objeto de estudo a circulação urbana na Avenida João Pessoa, localizada no bairro do Pedregulho, na cidade de Guaratinguetá – SP. Mediante os resultados obtidos foi possível elaborar diretrizes para a melhoria da circulação urbana da Avenida João Pessoa. A pesquisa foi realizada mediante aplicação de questionários. Fez-se também visitas técnicas, ao longo de toda avenida, com intuito de analisar e coletar dados sobre os principais problemas nela existentes.PALAVRAS-CHAVE: Avenida João Pessoa. Circulação urbana. Automóvel. MOVEMENT ANALYSIS OF URBAN IN AV. JOHN PERSON, GUARATINGUETÁ CITY AND INTERVENTION PROPOSAL ABSTRACTThis work was performed in order to deepen the studies on the automobile culture in Brazilian cities. We had as study object the urban movement in João Pessoa Avenue, located in the neighborhood of Gravel in the city of Guaratinguetá - SP. From the results obtained it was possible to draw up guidelines for the improvement of urban traffic of João Pessoa Avenue. The survey was conducted through questionnaires. It was held also technical visits, along the entire boulevard with intuited to analyze collect data on the main problems on the avenue.KEYWORDS: Avenue João Pessoa. Urban traffic. Car. MOVIMIENTO DE ANÁLISIS URBANO EN AV. JOHN PERSON, GUARATINGUETÁ CIUDAD Y PROPUESTA DE INTERVENCIÓN RESUMENEste trabajo se realizó con el fin de profundizar los estudios sobre la cultura del automóvil en las ciudades brasileñas. Tuvo como objeto de estudio el movimiento urbano en Avenida João Pessoa, ubicada en el barrio de Pedregulho en la ciudad de Guaratinguetá - SP. De los resultados obtenidos se pudo elaborar directrices para la mejora del tráfico urbano de João Pessoa Avenue.La encuesta se realizó por medio de cuestionarios. También hubo visitas técnicas, a lo largo de toda la avenida, con el objetivo de analizar y recopilar datos sobre los principales problemas en la avenida.PALABRAS CLAVE: Avenida João Pessoa. El tráfico urbano. Coche.
PROGRAMA PARA GERAÇÃO DE PROJETOS ARQUITETÔNICOS DE UNIDADE DE TRATAMENTO DE ÁGUA
Authors: Oliveira Rafael Montanhini Soares de , Sala Dominique Martins , Sozim Muriel Buzo , Tomaz Daniel Ferreira 
Published: December 2015

RESUMOSerá abordado nesse trabalho o desenvolvimento de um sistema computacional de pré-dimensionamento das unidades de floculação, decantação e filtração de uma ETA que possa gerar imagens com as dimensões calculadas e que essas imagens possam ser transferidas automaticamente para o software AutoCAD. Desta forma as imagens podem futuramente ser utilizadas para cálculos de estrutura das unidades de tratamento dando auxílio ao projetista em uma etapa inicial de projeto e ao estudante que tenha interesse na área. Com a geração deste programa pretende-se através do computador habilitar o acadêmico a desenvolver projetos de sistemas de tratamento com maior segurança e confiança. O programa desenvolvido sistema computacional de pré-dimensionamento das unidades de floculação, decantação e filtração de uma ETA, está sendo elaborado e gerando resultados bastante promissores. PALAVRAS-CHAVE:Dimensionamento de ETA, Python, AutoCAD. PROGRAM FOR ARCHITECTURAL PROJECT GENERATION OF WATER TREATMENT UNIT ABSTRACTIt will be approached that the development work of a computer system to pre – flocculation of the sizing units, decantation and filtration of an ETA that may generate images with the calculated dimensions and these images can be automatically transferred to the AutoCAD software. Thus the images can further be used to structure calculations of treatment units giving aid to the designer at a nearly stage of project and the student who has an interest in the area. With the generation of this program is intended through the computer to enable the students to develop treatment systems projects with greater security and confidence. The program developed computational system preliminary design of flocculation units, settling and filtration of ETA, is being prepared and generating very promising results.KEYWORDS: WTS diimension, Python. AutoCad. PROGRAMA PARA LA GENERACIÓN DE PROYECTO ARQUITECTÓNICO DE LA UNIDAD DE TRATAMIENTO DE AGUA RESUMENSe acercó a que el trabajo de desarrollo de un sistema informático para pre - floculación de lãs unidades de tamaño, decantación y filtración de una ETA que pueden generar imágenes com las dimensiones calculadas y estas imágenes se pueden transferir automáticamente al software AutoCAD. Así, lãs imágenes se pueden usar además de estructurar cálculos de unidades de tratamiento que Dan ayuda al diseñadoren una etapa temprana Del proyecto y el estudiante que tiene um interes em la zona. Com La generación de este programa se pretende a través de La computadora para permitir a los estudiantes a desarrollar proyectos de sistemas de tratamiento com mayor seguridad y confianza. El programa desarrollado sistema de diseño preliminar de cálculo de las unidades de floculación, sedimentación y filtración de ETA, está siendo preparado y generando resultados muy prometedores .PALABRAS CLAVE: dimensiones ETA, Python, AutoCad.