bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of allergenic potential for rice seed protein components utilizing a rice proteome database and an allergen database in combination with IgE-binding of recombinant proteins
Authors: Hirano Kana , Hino Shingo , Oshima Kenzi , Nadano Daita , Urisu Atsuo , Takaiwa Fumio , Matsuda Tsukasa 
Published: January 2016

AbstractAmong 131 rice endosperm proteins previously identified by MS-based proteomics, most of the proteins showed low or almost no sequence similarity to known allergens in databases, whereas nine proteins did it significantly. The sequence of two proteins showed high overall identity with Hsp70-like hazel tree pollen allergen (Cor a 10) and barley α-amylase (Hor v 16), respectively, whereas the others showed low identity (28–58%) with lemon germin-like protein (Cit l 1), corn zein (Zea m 50 K), wheat chitinase-like xylanase inhibitor (Tri a XI), and kinase-like pollen allergen of Russian thistle (Sal k 1). Immuno-dot blot analysis showed that recombinant proteins for these rice seed homologs were positive in the IgE-binding, but not necessarily similarity dependent, from some allergic patients. These results suggest that utilization of proteome and sequence databases in combination with IgE-binding analysis was effective to screen and evaluate allergenic potential of rice seed protein components.
Butterflies visit more frequently, but bees are better pollinators: the importance of mouthpart dimensions in effective pollen removal and deposition
Authors: Barrios Beyte , Pena Sean R. , Salas Andrea , Koptur Suzanne 
Published: January 2016

AbstractPollination studies often use visitation frequency of potential pollinators as an indicator of their importance, but this is only one component and may not reflect actual pollen transfer rates. In this study, we determine the most effective pollinator group of Angadenia berteroi , a tropical perennial subshrub with large yellow flowers that set few fruits. We determined visitation frequency and pollen transfer effectiveness of the four most common groups of visitors (long- and short-tongued bees, and skipper and non-skipper butterflies). Using potted plants, we exposed flowers to single visits from different types of pollinators to measure fruit set. We demonstrate that A. berteroi is most effectively pollinated by long-tongued bees, though many other species visit the flowers; the most frequent visitor group is not the most important pollinator, because they neither carry nor deposit much pollen, as the width of their proboscis is small compared with long-tongued bees. In this system, the width of the proboscis of the pollinators correlates with pollen transfer efficiency. Our results demonstrate the importance of pollen removal, pollen deposition, and fruit set, in determining the most effective pollinators, rather than visitor frequency. The distinctive morphology of these flowers, with a large bell and a narrow, short tube, suggests that other flowers of this shape may similarly benefit more from visitors with mouthparts shorter than previously considered optimal.
Climate change and non-stationary population processes in fisheries management
Authors: Szuwalski Cody S. , Hollowed Anne B. 
Published: January 2016

AbstractThe potential influence of climate change on the future distribution and abundance of fish (and therefore commercial fisheries and food security) is increasingly recognized in the fishery management community. A changing climate will likely have differing effects on different species; some will flourish, some will flounder. Management targets for fishing mortality and spawning biomass are often calculated by assuming stationary population processes, but under climate change, this assumption may be violated. Non-stationary population processes can introduce bias into estimates of biomass from stock assessments and calculations of target fishing mortalities and biomasses. However, few accepted frameworks exist for incorporating the changing influence of the environment on exploited populations into management strategies. Identifying changes in population processes due to environmental influences is important in order to enable climate-enhanced management strategy evaluations to elucidate the potential benefits and costs of changing management targets. Cost/benefit analyses will also be useful when coincidentally caught species respond differently to environmental change.
Interactive tools for inpatient medication tracking: a multi-phase study with cardiothoracic surgery patients
Authors: Wilcox Lauren , Woollen Janet , Prey Jennifer , Restaino Susan , Bakken Suzanne , Feiner Steven , Sackeim Alexander , Vawdrey David K 
Published: January 2016

AbstractObjective Prior studies of computing applications that support patients’ medication knowledge and self-management offer valuable insights into effective application design, but do not address inpatient settings. This study is the first to explore the design and usefulness of patient-facing tools supporting inpatient medication management and tracking.Materials and Methods We designed myNYP Inpatient, a custom personal health record application, through an iterative, user-centered approach. Medication-tracking tools in myNYP Inpatient include interactive views of home and hospital medication data and features for commenting on these data. In a two-phase pilot study, patients used the tools during cardiothoracic postoperative care at Columbia University Medical Center. In Phase One, we provided 20 patients with the application for 24–48 h and conducted a closing interview after this period. In Phase Two, we conducted semi-structured interviews with 12 patients and 5 clinical pharmacists who evaluated refinements to the tools based on the feedback received during Phase One.Results Patients reported that the medication-tracking tools were useful. During Phase One, 14 of the 20 participants used the tools actively, to review medication lists and log comments and questions about their medications. Patients’ interview responses and audit logs revealed that they made frequent use of the hospital medications feature and found electronic reporting of questions and comments useful. We also uncovered important considerations for subsequent design of such tools. In Phase Two, the patients and pharmacists participating in the study confirmed the usability and usefulness of the refined tools.Conclusions Inpatient medication-tracking tools, when designed to meet patients’ needs, can play an important role in fostering patient participation in their own care and patient-provider communication during a hospital stay.
Search for gas bulk motions in eight nearby clusters of galaxies with Suzaku
Authors: Ota Naomi , Yoshida Hiroko 
Published: January 2016

Abstract
To search for bulk motions of the intracluster medium, we analyzed X-ray spectra taken with the Suzaku satellite, and measured the Doppler shift of the Fe-K line emission from eight nearby clusters of galaxies with various X-ray morphologies. In the cores of the Centaurus and Perseus clusters, the gas bulk velocity does not exceed the sound velocity, which confirms the results of previous researchs. For the Cen 45 subcluster, we found that the radial velocity relative to the Centaurus core, &lt;780 km s−1, is significantly smaller than that reported in the optical band at the 3.9 σ level, which suggests an offset between the gas and galaxy distributions along the line of sight due to the subcluster merger. In A 2199, A 2142, A 3667, and A 133, no significant bulk motion was detected, indicating an upper limit on the radial velocity of 3000–4000 km s−1. A sign of large bulk velocity in excess of the instrumental calibration uncertainty was found near the center of the cool-core cluster A 2029 and in a subcluster of the merging cluster A 2255, suggesting that the nonthermal pressure support is not negligible in estimating the total gravitational mass of not only merging clusters, but also relaxed clusters, as predicted by numerical simulations. To improve the significance of the detection, however, a further examination by follow-up observations is required. The present study provides a pilot survey prior to future high-resolution spectroscopy with ASTRO-H, which is expected to play a critical role in revealing the dynamical evolutions of clusters.
Protein Kinase C γ Interneurons Mediate C-fiber–induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber–induced Nociceptive Behavior
Authors: Peirs Cedric , Bourgois Nathalie , Artola Alain , Dallel Radhouane 
Published: January 2016

AbstractAbstract
Static mechanical allodynia was associated with the activation of interneurons in laminae I-II and II-III. Among them were many protein kinase C (PKC) γ–expressing cells of inner lamina II (IIi). γ-Aminobutyric acid receptor type A (GABAA) antagonism or reactive oxidative species (ROS) generation are sufficient to induce static mechanical allodynia. GABAA agonism, PKCγ inhibition, and ROS scavengers prevented static mechanical allodynia. The data are consistent with the premise that sensitization of PKCγ interneurons in lamina IIi is required for static mechanical allodynia and that this sensitization is driven by ROS and GABAAergic disinhibition.
Supplemental Digital Content is available in the text.

Background
Tissue injury enhances pain sensitivity both at the site of tissue damage and in surrounding uninjured skin (secondary hyperalgesia). Secondary hyperalgesia encompasses several pain symptoms including pain to innocuous punctate stimuli or static mechanical allodynia. How injury-induced barrage from C-fiber nociceptors produces secondary static mechanical allodynia has not been elucidated.

Methods
Combining behavioral, immunohistochemical, and Western blot analysis, the authors investigated the cell and molecular mechanisms underlying the secondary static mechanical allodynia in the rat medullary dorsal horn (MDH) using the capsaicin model (n = 4 to 5 per group).

Results
Intradermal injection of capsaicin (25 μg) into the vibrissa pad produces a spontaneous pain and a secondary static mechanical allodynia. This allodynia is associated with the activation of a neuronal network encompassing lamina I–outer lamina III, including interneurons expressing the γ isoform of protein kinase C (PKCγ) within inner lamina II (IIi) of MDH. PKCγ is concomitantly phosphorylated (+351.4 ± 79.2%, mean ± SD; P = 0.0003). Mechanical allodynia and innocuous punctate stimulus–evoked laminae I to III neuronal activation can be replicated after intracisternally applied γ-aminobutyric acid receptor type A (GABAA) antagonist (bicuculline: 0.05 μg) or reactive oxygen species (ROS) donor (tert-butyl hydroperoxide: 50 to 250 ng). Conversely, intracisternal PKCγ antagonist, GABAA receptor agonist, or ROS scavenger prevent capsaicin-induced static mechanical allodynia and neuronal activation.

Conclusions
Sensitization of lamina IIi PKCγ interneurons is required for the manifestation of secondary static mechanical allodynia but not for spontaneous pain. Such sensitization is driven by ROS and GABAAergic disinhibition. ROS released during intense C-fiber nociceptor activation might produce a GABAAergic disinhibition of PKCγ interneurons. Innocuous punctate inputs carried by Aδ low-threshold mechanoreceptors onto PKCγ interneurons can then gain access to the pain transmission circuitry of superficial MDH, producing pain.
SOLITARY CIRCUMSCRIBED “PEARL WHITE” RETINAL MASS (SO-CALLED RETINAL ASTROCYTIC PROLIFERATION) RESIDES IN DEEP RETINA OR BENEATH RETINA: FINDINGS ON MULTIMODAL IMAGING IN 4 CASES
Authors: Shields Carol L. , Roe Richard , Yannuzzi Lawrence A. , Shields Jerry A. 
Published: January 2016

Purpose:
To report novel observations of previously described solitary circumscribed retinal astrocytic proliferation using spectral domain optical coherence tomography that suggests this tumor does not arise in the nerve fiber layer as initially believed, but arises within deep retinal or retinal pigment epithelial structures.

Methods:
Retrospective review of four cases.

Results:
Patient age ranged from 46 to 75 years. The tumor was pearl white or yellow-white (n = 4, 100%), located in the macula (n = 1, 25%) or macula to equator (n = 3, 75%) regions, and with mean tumor base of 1.2 mm and thickness of 0.8 mm. There were no feeding vessels, intrinsic vessels, subretinal fluid, or vitreoretinal traction. Mild surrounding retinal pigment epithelial hyperplasia and atrophy rimmed each tumor (n = 4, 100%). Fluorescein angiography depicted the mass with early hypofluorescence (n = 3/3, 100%) and late hypofluorescence (n = 2/3, 67%). Spectral domain optical coherence tomography demonstrated the mass with an abruptly elevated “snowball” configuration (n = 4, 100%), with smooth or slightly irregular surface (n = 4, 100%), and originating from deep retina or retinal pigment epithelial (n = 4, 100%), with overlying compression and draping of retinal tissue (n = 4, 100%).

Conclusion:
This previously described small yellow-white retinal tumor appears to arise in the outer retinal layers and not from the inner retinal layers as formerly believed. This tumor may not be astrocytic as initially believed since it arises deep within the retina, but it could represent a deep glial or pigment epithelial fibrous mass. The pathogenesis and pathology of this rare lesion remain unknown.
Severe Thrombocytopenia in the Third Trimester of Pregnancy Subsequent to Seasonal Non-H1N1 Influenza A Virus Infection
Authors: Curtis Samantha , Carlan Stephen , Busowski John , Busowski Mary , Musa Faisal 
Published: January 2016

Background
Viral infections can induce hematological disorders including immune thrombocytopenic purpura (ITP). Influenza-induced ITP is infrequent and has never been reported in a third-trimester pregnant woman.

Case
A previously healthy pregnant woman in the third trimester presented with non-H1N1 Influenza A and a platelet count of 0. She was diagnosed with ITP and treated with intravenous immunoglobulin and oseltamivir. Her platelet count returned to normal by day 8, and she delivered vaginally a normal infant who had no evidence of thrombocytopenia or Influenza.

Conclusions
Influenza A can induce secondary ITP in pregnancy, and the standard treatment for both ITP and Influenza A is effective.
Compound Motor Action Potential: Electrophysiological Marker for Muscle Training
Authors: Molin Carl Johan , Punga Anna R. 
Published: January 2016

Purpose:
The compound motor action potential (CMAP) represents the summated action potentials of all stimulated motor endplates and potentially reflects muscle hypertrophy and increased muscle contractions. Since electrophysiological biomarkers for high-resistance strength training are lacking, the authors evaluated whether the CMAP of distal and proximal muscles differs between healthy men and women who perform and do not perform high-resistance muscle training.

Methods:
Motor neurography was performed with stimulation of the median nerve (recording of abductor pollicis brevis muscle), peroneal nerve (recording of extensor digitorum brevis muscle), femoral nerve (recording of rectus femoris muscle) and musculocutaneous nerve (recording of biceps brachii muscle), and isometric muscle strength, measured with a hand-held dynamometer, were performed on 83 healthy subjects (52 women).

Results:
Trained women had 25% higher CMAP amplitude in the rectus femoris muscle than untrained women (P < 0.001), whereas CMAP amplitude in the trained male cohort was 25% higher in the biceps (P = 0.005) compared with untrained men. In the trained group, CMAP amplitude in the biceps correlated with isometric muscle strength (R = 0.30; P = 0.046).

Conclusions:
The authors' propose the CMAP as an objective neurophysiological parameter for proximal muscle status and training effects in future interventional studies of patients with neuromuscular disorders.
Urinary infection due to Balantioides coli: a rare accidental zoonotic disease in an addicted and diabetic young female in Iran
Authors: Soleimanpour Saman , Babaei Ali , Roudi Abdolghayyoum Movahhedi , Raeisalsadati Seyedeh Sara 
Published: January 2016

Background:
Balantiosis, a rare zoonotic infection resulting in dysentery, is caused by the large ciliated protozoan parasite Balantioides coli. Humans acquire this organism via the faecal–oral route. Very rarely, extraintestinal infections can occur in the urinary tract system. There are very few case reports of urinary balantiosis in humans.

Case presentation:
Here, an interesting case of urinary balantiosis in a 35-year-old addicted woman with multiple health problems including spontaneous abortion and diabetes is reported. Her midstream urine sample, collected while all sterile precautions were being taken, demonstrated B. coli along with Trichomonas vaginalis and bacteria. B. coli was identified by its characteristic morphology and rapid rotary motility in the urinary tract, which is an abnormal site for invasion by this parasite.

Conclusion:
To the best of our knowledge, this is only the eighth case described in literature in which B. coli was detected in urine sediment; it is reported for its rarity and for future reference.
Exploring trainers’ engaging instructional practices: a collective case study
Authors: Arghode Vishal , Wang Jia 
Published: January 2016

Purpose
– This study aims to explore the phenomenon of training engagement from the trainers’ perspective. Specifically, two questions guided this inquiry. First, how do trainers define engagement in the training context? and What strategies do trainers use to engage trainees?

Design/methodology/approach
– The collective case study approach was adopted for this qualitative study. Seven cases were selected for in-depth analyses. Data were collected through individual, face-to-face interviews and analyzed using the constant comparative analysis method.

Findings
– Major findings suggest that engaging training practices take various forms. They include being trainee-centered, maximizing learning through entertaining and interesting instruction, accommodating different learning styles, eliciting trainee participation by creating an encouraging learning environment and connecting with trainees by building rapport early in a training session.

Research limitations/implications
– The small sample limits the generalizability of the findings. However, this study expands training literature by focusing on an under-explored research area, the role of engaging trainees in maximizing learning outcomes.

Practical implications
– For trainers, this study offered some specific strategies they can use to engage learners in the training context to achieve desired learning outcomes. In addition, the seven cases selected for this study may be used as a benchmark against which both experienced and novice trainers compared their own practices.

Originality/value
– This is one of very few qualitative studies with a focus on emotional aspects involved in training. The rich data from this study shed light on areas for future improvement, particularly regarding how to effectively engage trainees to maximize learning outcomes.
The flipped classroom, a review of the literature
Authors: Zuber William James 
Published: January 2016

Purpose
– The purpose of this paper is to explore a set of literature in order to clarify the flipped classroom methods (FCM) theoretical frameworks and to determine if the evidence shows improvements in learning for students in comparison with traditional teaching methods.

Design/methodology/approach
– The paper took a literature review approach and explored five articles selected with specific criteria of being published within 2013-2014 and that used comparisons with flipped and traditional classroom methods that employed analysis of student assessment outcomes.

Findings
– The paper shows inconsistent theoretical frameworks and inconclusive evidence of an improvement in assessment outcomes for students. It finds the research undertaken in the literature is limited in scope and suggests further research into the FCM is required to determine consistent theoretical frameworks and methods.

Research limitations/implications
– The findings of the paper may be limited by the selection of literature reviewed and generalisability therefore researchers are encouraged to explore further.

Practical implications
– The paper holds potential implications to question the consistency, validity and benefits of the flipped classroom.

Social implications
– Many anecdotal articles herald the flipped classroom as a method of improving learning outcomes for students, however, academic literature suggests the evidence is inconclusive and there are implications on using educational methods based on technology.

Originality/value
– The paper identifies the need for further research into the flipped classroom and supports the advancement of educational methodology.
The kaleidoscope called leadership
Authors: Bennett Robert J 
Published: January 2016

Purpose
– Leadership is a complex concept that is discussed often in many books, blogs and articles, which try to identify those necessary traits to make one a leader. But leadership is ambiguous in that the characteristics that makes one a leader in one situation may not work and may even be detrimental in a similar one. Defining it is difficult, knowing it when you see it is easy. The purpose of this paper is to intend to make you aware of its complexity and your ability to become a leader yourself.

Design/methodology/approach
– By briefly comparing two successful but dissimilar leaders, the scope and breadth of leadership is introduced. Rather than attempting to define leadership, the paper proceeds to talk about what leadership is not, and why. It ends with an affirmation of our ability to become a leader and a “nudge” to develop those leadership skills we already possess.

Findings
– The paper suggests leadership is autological, something which defines itself, and that it is seen as different by every individual. It also proposes that we all have leadership traits within us and that whether we are consciously aware of it or not, we act as leaders every day.

Practical implications
– The thoughts this paper evokes can help those who are in leadership positions, those striving to become better leaders, and those who are not aware of their leadership potential by broadening their perspectives of leadership and our ability to attain it.

Originality/value
– This paper presents leadership in a unique manner, identifying its complexities while providing assurances it can be attained.