bluuebunny/crossref_metadata_2025_split huggingface dataset:
Media influence on public trust during crises: A comparative analysis of different media types and trust dimensions
Authors: Zhang Qing , Zhang Xiaojun 
Published: September 2024

AbstractThis study aims to reveal how media influence public trust during crises and whether these mechanisms vary by media type, trust dimensions, government levels, and regions. Using the COVID‐19 pandemic as a case study, we surveyed 31 provincial‐level regions in China from April 22 to 28, 2020, analysed the data with Stata 16.0, and drew the following conclusions. First, the mechanisms by which social media and traditional media influence public trust differ significantly. Social media can only directly impact outgroup trust or reduce both government trust and outgroup trust by lowering citizens' perceptions of government performance (CPGP). In contrast, traditional media directly enhance public trust across all dimensions and can also indirectly increase trust by boosting CPGP. Second, traditional media affect trust in both local and central governments, while social media have no significant effect. Third, citizens' perceptions of central and local government performance play distinct roles in this process. Finally, the impact of media on public trust varies between urban and rural areas and across different regions.
Improving the rheological properties of ultra‐processed powdered goat milk beverage using texture additives
Authors: Andrade Mychelle de Lira , Alcântara Maristela Alves , Santana Amanda Marília da Silva , Diniz Natasha Carolina Melo , Ferreira Rodholfo da Silva Barbosa , Pereira Emmanuel Moreira , da Silva Fabio Anderson Pereira 
Published: September 2024

AbstractThis study aimed to investigate the static and dynamic rheological properties of an ultra‐processed powdered goat milk beverage containing carboxymethyl cellulose (CMC), guar gum (GG), and xanthan gum (XG), using a mixture design. Fourteen samples were evaluated, in addition to the original beverage. The flow curves classified the fluids as non‐Newtonian and characterized all the reconstituted beverages with pseudoplastic behavior, precisely due to the addition of hydrocolloids that increased the viscosity, and the fresh beverage sample showed the behavior of a dilatant fluid. The stress sweep verified the changes in the storage module (G′) and the loss module (G″), the G′ ranged from 1.97 to 20.36 (Pa) and the G″ ranged from 5.94 to 11.30 (Pa), demonstrating that there was the formation of beverages with elastic and viscous behaviors. The results showed a synergistic effect between the texture improvers, and the formulations with GG identified a greater effect on the tension. The frequency sweep tests showed that the behavior of the samples was that of a weak gel; however, when subjected to a certain frequency, the values of G′ exceeded the value of G″, becoming a sample with more elastic characteristics and consequently, presenting the behavior of a stronger gel. Finally, according to the data presented, it is assumed that formulations containing GG and xanthan gum may produce desirable consumer properties for the reconstituted goat milk drink. Samples with a higher concentration of GG exhibited improved rheological performance, characterized by greater consistency, increased resistance to tension, and higher viscosity at low frequencies.Practical ApplicationThe powdered goat milk drink is an innovative product that meets the demands of the food industry and consumers by offering a nutritious and sustainable beverage alternative.
A review on rebaudioside M: The next generation steviol glycoside and noncaloric sweetener
Authors: Okonkwo Clinton E. , Adeyanju Adeyemi A. , Onyeaka Helen , Nwonuma Charles Obiora , Olaniran Abiola F. , Alejolowo Omokolade Oluwaseyi , Inyinbor Adejumoke A. , Oluyori Abimbola Peter , Zhou Cunshan 
Published: September 2024

AbstractSo far, the use of artificial low‐calorie sweeteners, like sucralose, saccharin, and so on, to replace the conventional‐based sugars has not succeeded due to the long‐term adverse health effects, for example, hypertension, and not well‐known safety stand. In this review, we discussed the next generation SvGl (rebaudioside M [Reb M]), their biosynthetic pathway in plant, high‐yield production via microbial fermentation and enzyme engineering, physicochemical properties, taste modification, kinetic metabolism, application in food and beverages, safety and toxicological evaluation, regulation and dosage recommendation, and health benefits. In stevia, the biosynthesis of stevia glycosides, especially Reb M, is derived from the bifurcation of the pathway leading to gibberellin, followed by subsequent enzymatic modification of rubusoside. Reb M is more economically produced via microbial fermentation of modified yeast Yarrowia lipolytica and enzymatic bioconversion of rebaudioside A (Reb A) or Reb E. Reb M can serve as a suitable alternative to the conventional‐based sugars.
Tissue‐specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging
Authors: Kurosawa Tamaki , Ikemoto‐Uezumi Madoka , Yoshimoto Yuki , Minato Keitaro , Kaji Noriyuki , Chaen Takashi , Hase Eiji , Minamikawa Takeo , Yasui Takeshi , Horiguchi Kazuhide , Iino Satoshi , Hori Masatoshi , Uezumi Akiyoshi 
Published: September 2024

AbstractMesenchymal stromal cells (MSCs), also known as fibro‐adipogenic progenitors, play a critical role in muscle maintenance and sarcopenia development. Although analogous MSCs are present in various tissues, recent single‐cell RNA‐seq studies have revealed the inter‐tissue heterogeneity of MSCs. However, the functional significance of MSC heterogeneity and its role in aging remain unclear. Here, we investigated the properties of MSCs and their age‐related changes in seven mouse tissues through histological, cell culture, and genetic examinations. The tissue of origin had a greater impact on the MSC transcriptome than aging. By first analyzing age‐related changes, we found that Kera is exclusively expressed in muscle MSCs and significantly down‐regulated by aging. Kera knockout mice recapitulated some sarcopenic phenotypes including reduced muscle mass and specific force, revealing the functional importance of Kera in the maintenance of muscle youth. These results suggest that MSCs have tissue‐specific supportive functions and that deterioration in these functions may trigger tissue aging.
Impact of extracorporeal blood pump gap sizes on the performance and hemocompatibility under off‐design operation
Authors: Fischer Lars , Jansen Sebastian V. , Steinseifer Ulrich , Yen Ifan , Hsu Po‐Lin , Neidlin Michael 
Published: September 2024

AbstractBackgroundHemocompatibility remains the dominant challenge in rotary blood pumps, and more information on the relationship between individual pump design features, hemodynamics, and blood trauma in various operation conditions is necessary. The study evaluated the variation of gap sizes in extracorporeal blood pumps concerning their influence on blood compatibility, particularly during off‐design conditions.MethodsWe developed a parametric generic blood pump framework for in‐silico and in‐vitro design feature analysis. Thirty‐six designs with varying axial and radial gap sizes between 0.5 mm and 3 mm were generated. CFD was applied to calculate and compare device hemodynamics and evaluate the performance and hemocompatibility during off‐design and target operation conditions. The following quantities were analyzed: pressure difference, hemolysis potential, residence times, hydraulic efficiency, and recirculation ratio.ResultsThe in‐vitro prototype showed excellent agreement with in‐silico predictions regarding hydraulic performance (R2 = 0.996 with a RMSE = 2.07). Our results show a modest impact of gap size variations ±10% on key metrics. Domain‐resolved analyses revealed a significant contribution of the gap regions to the device's overall hemolytic performance, with an increasing contribution for off‐design flow rates. Overall elevated hemolysis levels were identified if at least one gap size was held minimal.ConclusionsWe introduced and showed the feasibility of a parametric rotary blood pump framework to systematically investigate design feature impact. Results suggest, larger and uniformly sized gaps being overall beneficial regarding hemocompatibility.
Knowledge gaps and opportunities for conservation with orchid collectors in Vietnam
Authors: Davis Elizabeth Oneita , Graves Adam , Block Heinfried , Powell Christy , Cao Trung Tien 
Published: September 2024

AbstractUnsustainable harvesting of orchid species is a critical, global threat to orchid diversity and abundance, fueled by domestic and global demand. However, drivers of demand continue to be under‐explored, despite opportunities for proactive engagement and/or behavior change strategies with and/or directed at orchid collectors. In this study, we surveyed self‐identified Vietnamese orchid collectors, some of whom were also known to engage in wild harvesting of endangered species, to understand sociological dimensions including motivations, knowledge, attitudes, behaviors, and conservation ethos. We found that knowledge about domestic and international regulations was low, and that orchid collectors were likely to believe that Vietnam has plenty of orchids left in the wild. Orchid collectors were highly willing to share their expertise and collections with international NGOs, and receive advice on propagation of orchid species. Through Bayesian logistic regression, we found no statistically significant influence of demographic attributes on the behavior of harvesting from the wild; however, having access to propagation equipment and supplies increased the likelihood of wild harvest. Accurate knowledge (awareness) is a key first step in the behavior change process. We suggest the implementation of awareness‐raising campaigns targeted at Vietnamese orchid collectors, which communicate domestic and international restrictions about orchid harvest and trade, as well as the known status of orchid species in the wild. Additionally, we suggest that an opportunity exists to recruit Vietnamese orchid collectors into a formal network for knowledge‐sharing and the co‐creation of sustainable guidelines around keeping and propagating orchids.Abstract in Vietnamese is available with online material.
Haemorrhagic cerebrovascular accident or stroke in a 16‐year‐old Cob mare
Authors: Potier Julie F. N. , Prutton Jamie S. W. 
Published: September 2024

SummaryThis paper describes the clinical and histopathological features of a 16‐year‐old Cob mare who sustained a haemorrhagic cerebrovascular accident or stroke. The mare presented with an acute onset of neurological signs, with a neuroanatomical localisation to the midbrain and thalamus regions. The mare was reported to have suffered from ataxia on all four limbs which started 7 days prior to referral and was also showing several signs of left‐sided cranial nerve deficits. On initial examination, the mare presented with quadrilateral ataxia, left‐sided facial paralysis, weak tongue tone and a left‐sided nose tilt as well as a hemineglect syndrome characterised by an inability to eat food presented on the right side of her mouth. Complete blood count and biochemistry analyses did not reveal any abnormalities, and a standing head CT revealed the presence of a hyperdense lesion localised in the left ventral cortex and thalamus region, which could be consistent with a vascular lesion, cholesterol granuloma or a mass. The mare was monitored, and as her condition slightly improved, was discharged from the hospital. Four weeks later, the clinical signs recurred and as the ataxia presented a danger for the mare and anyone handling her, the decision was made to euthanise the mare. A post‐mortem CT scan of the head revealed an enlargement of the previous lesion, and the histopathological examination confirmed the presence of a haemorrhage within the brain, associated with neoplastic emboli. Haemorrhagic stroke has not previously been well described in horses therefore presents a challenge in diagnosis. Treatment in small animals is mainly conservative.
Personal and Workplace Characteristics as Predictors of Intent‐To‐Stay Among Registered Nurses: An Exploratory Quantitative Multicentre Study
Authors: Chua Ming Marcus , Ang Wei How Darryl , Siew An Ling , Chen Hui‐Chen 
Published: September 2024

ABSTRACTAimThis study aims to describe and examine the factors associated with registered nurses' intent‐to‐stay and subsequently identify predictors of nurses' intent‐to‐stay.DesignA quantitative, cross‐sectional correlational design was used.MethodsA convenience sample of 270 registered nurses completed the questionnaire and was included in this study. Descriptive statistics were used to present the sociodemographic characteristics and scores of outcome measures. Pearson's correlation coefficient and multiple linear regression with backward selection were conducted to examine how nurses' characteristics and workplace factors influence nurses' intent‐to‐stay.ResultsThe mean age of the participants was 29.2 years. The mean scores for the outcomes were intent‐to‐stay (mean = 2.96), resilience (mean = 3.34), occupational self‐efficacy (mean = 4.34), sleep quality (mean = 9.73) and workplace environment scores (mean = 3.15). The correlation analysis showed that resilience, occupational self‐efficacy, self‐realisation and workload were positively correlated to intent‐to‐stay while sleep quality was negatively correlated to intent‐to‐stay. Multiple linear regression analysis found occupational self‐efficacy, sleep quality, workload, nervousness, nurses' designation and specialisation status to be significant factors associated with intent‐to‐stay.ConclusionIntent‐to‐stay is a complex and multidimensional construct influenced by a variety of personal and workplace factors. Hospital administrators should endeavour to develop measures to improve occupational self‐efficacy, workload, nervousness and push for specialisation training to bolster nurses' intent‐to‐stay.ImpactAgainst an everchanging healthcare landscape following the COVID‐19 pandemic, the findings of this study contribute to a deeper understanding of the factors of registered nurses' intent‐to‐stay. The findings of this study alluded to the importance of professional development and workload as factors that can influence registered nurses' intent‐to‐stay. Hospital administrators can prioritise workforce retention policies by introducing strategies such as opportunities for upskilling, flexible working hours and streamlining work processes to promote nurses' intent‐to‐stay.Patient or Public ContributionNo patient or public contribution.
Identification of Major Locus Conferring Resistance to Urdbean Leaf Crinkle Disease in Black Gram [Vigna mungo (L.) Hepper]
Authors: Palanivelu Sathya , Narayana Manivannan , Palaniappan Viswanathan 
Published: September 2024

ABSTRACTUrdbean leaf crinkle disease (ULCD) is a major factor causing severe yield loss in black gram production. The identification of quantitative trait loci (QTL) linked to ULCD resistance is highly useful in breeding programmes. A mapping population was developed from a cross between the resistant parent CO 5 and the susceptible parent TU 68. ULCD screening was carried out through the artificial sap inoculation method. In the F2:3 population, the ULCD score was assessed 60 days after infection. Composite interval mapping was carried out with a 1000‐run permutation. Another mapping population, VBN(Bg) 4 × CO 5 in F2:3 generation was used to validate the identified QTL. A single locus, qULCD3.1 was identified in linkage group 3. It explains 17.98% of the variation in ULCD resistance. Markers VR086 and CEDG 305 flanked the QTL region. The marker CEDG 305 explains 20.5% of the phenotypic variation for ULCD resistance in the validation population VBN(Bg) 4 × CO 5. This is the first report to identify a QTL for ULCD disease resistance. The identified markers can be used to incorporate ULCD resistance in black gram through marker‐assisted selection.
Temporal progression of sleep electroencephalography features in isolated rapid eye movement sleep behaviour disorder
Authors: Angerbauer Raphael , Stefani Ambra , Zitser Jennifer , Ibrahim Abubaker , Anselmi Victoria , Süzgün Merve Aktan , Egger Kristin , Brandauer Elisabeth , Högl Birgit , Cesari Matteo 
Published: September 2024

SummaryPrevious studies indicated that patients with isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) exhibit alterations in spectral electroencephalographic (EEG), spindle, and slow‐wave features. As it is currently unknown how these EEG features evolve over time, this study aimed to evaluate their temporal progression in patients with iRBD in comparison to controls. We included 23 patients with iRBD and 23 controls. Two polysomnographies (baseline and follow‐up) were recorded with a mean (standard deviation) interval of 4.0 (2.5) years and were automatically analysed for sleep stages, spectral bandpower, spindles, and slow waves. We used linear models to evaluate differences at each time point, and linear mixed‐effects models to analyse differences in temporal progression between the groups. At baseline, patients with iRBD presented EEG slowing both in REM (expressed as significantly reduced α‐bandpower and increased δ‐bandpower in frontal channels) and in non‐REM (NREM) sleep (significantly increased slow‐to‐fast ratio in central channels). These differences vanished at follow‐up. In both REM and NREM sleep, γ‐bandpower was increased at follow‐up in patients with iRBD, resulting in significantly different temporal progression between groups (in occipital channels during REM sleep and frontal channels during NREM sleep). Relative power of sleep spindles was significantly higher at baseline in patients with iRBD in frontal channels, but we observed a significant reduction over time in central channels. Finally, slow waves were significantly shorter in patients with iRBD at both time‐points. Our results underscore the need of considering longitudinal data when analysing sleep EEG features in patients with iRBD. The observed temporal changes as markers of progression of neurodegeneration require further investigations.
Association between lung function and sleep disorder symptoms in a community‐based multi‐site case‐finding study
Authors: Mazzola Rosetta , Aaron Shawn D. , Vandemheen Katherine L. , Mulpuru Sunita , Bergeron Celine , Lemière Catherine , Côté Andréanne , Boulet Louis‐Philippe , Field Stephen K. , Penz Erika , McIvor R. Andrew , Gupta Samir , Mayers Irvin , Bhutani Mohit , Hernandez Paul , Lougheed M. Diane , Licskai Christopher J. , Azher Tanweer , Ezer Nicole , Ainslie Martha , Kendzerska Tetyana 
Published: September 2024

SummaryObstructive airway disease is associated with sleep disturbances. We aimed to assess the relationship between lung function and sleep disorder symptoms using cross‐sectionally collected data between March 2017 and August 2021 from the Undiagnosed Chronic Obstructive Pulmonary Disease and Asthma Population study, a prospective community‐based multi‐site case‐finding study. Undiagnosed Chronic Obstructive Pulmonary Disease and Asthma Population study participants with respiratory symptoms but without diagnosed lung disease who completed spirometry and the Global Sleep Assessment Questionnaire were included. We conducted multivariate linear regression models for forced expiratory volume in 1 s, forced vital capacity and forced expiratory volume in 1 s/forced vital capacity by Global Sleep Assessment Questionnaire responses adjusted for confounders. The same models were employed to examine respiratory symptoms, as reported on the St George's Respiratory Questionnaire and Chronic Obstructive Pulmonary Disease Assessment Test, by Global Sleep Assessment Questionnaire responses. Logistic regression models were used to assess the association of undiagnosed obstructive airway disease with sleep symptoms. Amongst 2093 adults included in the study, 48.3% were female and the median age was 63 years (interquartile range 53–72). Two‐hundred and five (9.79%) subjects met spirometry criteria for undiagnosed chronic obstructive pulmonary disease, and 191 (9.13%) for undiagnosed asthma. There were no significant associations between spirometry measures and sleep symptoms (p > 0.5), controlling for age, sex, body mass index, smoking and comorbidities. Those with undiagnosed asthma were more likely to report insomnia “at least sometimes” versus “never” (odds ratio 2.58, 95% confidence interval: 1.27–6.19, p = 0.02). Respiratory symptoms were associated with sleep symptoms, with significant (p < 0.05) increases in St George's Respiratory Questionnaire and Chronic Obstructive Pulmonary Disease Assessment Test scores in those reporting most sleep symptoms. Overall, we found an association between undiagnosed asthma and insomnia, and between respiratory and sleep disorder symptoms.
PDE9A Inhibition Improves Coronary Microvascular Rarefaction and Left Ventricular Diastolic Dysfunction in the ZSF1 Rat Model of HFpEF
Authors: Fopiano Katie Anne , Zhazykbayeva Saltanat , El‐Battrawy Ibrahim , Buncha Vadym , Pearson William M. , Hardell Davis J. , Lang Liwei , Hamdani Nazha , Bagi Zsolt 
Published: September 2024

ABSTRACTObjectiveHeart failure with preserved ejection fraction (HFpEF) commonly arises from comorbid diseases, such as hypertension, obesity, and diabetes mellitus. Selective inhibition of phosphodiesterase 9A (PDE9A) has emerged as a potential therapeutic approach for treating cardiometabolic diseases. Coronary microvascular disease (CMD) is one of the key mechanisms contributing to the development of left ventricular (LV) diastolic dysfunction in HFpEF. Our study aimed to investigate the mechanisms by which PDE9A inhibition could ameliorate CMD and improve LV diastolic function in HFpEF.Methods and ResultsThe obese diabetic Zucker fatty/spontaneously hypertensive heart failure F1 hybrid (ZSF1) rat model of HFpEF was employed in which it was found that a progressively developing coronary microvascular rarefaction is associated with LV diastolic dysfunction when compared to lean, nondiabetic hypertensive controls. Obese ZSF1 rats had an increased cardiac expression of PDE9A. Treatment of obese ZSF1 rats with the selective PDE9A inhibitor, PF04447943 (3 mg/kg/day, oral gavage for 2 weeks), improved coronary microvascular rarefaction and LV diastolic dysfunction, which was accompanied by reduced levels of oxidative and nitrosative stress markers, hydrogen peroxide, and 3‐nitrotyrosine. Liquid chromatography–mass spectrometry (LC–MS) proteomic analysis identified peroxiredoxins (PRDX) as downregulated antioxidants in the heart of obese ZSF1 rats, whereas Western immunoblots showed that the protein level of PRDX5 was significantly increased by the PF04447943 treatment.ConclusionsThus, in the ZSF1 rat model of human HFpEF, PDE9A inhibition improves coronary vascular rarefaction and LV diastolic dysfunction, demonstrating the usefulness of PDE9A inhibitors in ameliorating CMD and LV diastolic dysfunction through augmenting PRDX‐dependent antioxidant mechanisms.