bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic obstructive pulmonary disease and the risk of stroke: a systematic review protocol
Authors: Morgan Ann D , Sharma Chetna , Rothnie Kieran J , Quint Jennifer K 
Published: November 2016

IntroductionThere is good evidence to suggest that chronic obstructive pulmonary disease (COPD) increases the risk of ischaemic heart disease, in particular myocardial infarction (MI). The relationship between stroke and COPD, however, is not as well established, and studies conducted to date have generated conflicting results.Methods and analysisMEDLINE and Embase will be searched for relevant articles using a prespecified search strategy. We will target observational studies conducted in the general population that employ either a longitudinal cohort or case–control study design to estimate ORs, HRs or incident rate ratios for the association between COPD and a subsequent first stroke. Both stages of screening, title and abstract followed by full-text screening, will be conducted independently by two reviewers. The Population, Exposure, Comparator, Outcomes, Study characteristics (PECOS) framework will be used to systematise the process of extracting data from those studies meeting our selection criteria. Study quality will be assessed using an adapted version of the Newcastle-Ottawa risk of bias tool. The data extraction and the risk of bias assessment will also be conducted in duplicate. A meta-analysis will be considered if there is sufficient homogeneity across selected studies or groups of studies. If a meta-analysis is not justified, a narrative synthesis will be conducted. Selected Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria will be used to assess the quality of the cumulative evidence.DisseminationCurrently ranking second and fourth in the list of global causes of mortality, respectively, stroke and COPD are important non-communicable diseases. With this review, we hope to clarify some of the current uncertainty that surrounds the COPD–stroke relationship and in turn improve understanding of the nature of the role of COPD in comorbid stroke.Prospero registration numberCRD42016035932.
Study protocol: a phase III randomised, double-blind, parallel arm, stratified, block randomised, placebo-controlled trial investigating the clinical effect and cost-effectiveness of sertraline for the palliative relief of breathlessness in people with chronic breathlessness
Authors: Watts Gareth J , Clark Katherine , Agar Meera , Davidson Patricia M , McDonald Christine , Lam Lawrence T , Sajkov Dimitar , McCaffrey Nicola , Doogue Matthew , Abernethy Amy P , Currow David C 
Published: November 2016

IntroductionBreathlessness remains a highly prevalent and distressing symptom for many patients with progressive life-limiting illnesses. Evidence-based interventions for chronic breathlessness are limited, and there is an ongoing need for high-quality research into developing management strategies for optimal palliation of this complex symptom. Previous studies have suggested that selective serotonin reuptake inhibitors such as sertraline may have a role in reducing breathlessness. This paper presents the protocol for a large, adequately powered randomised study evaluating the use of sertraline for chronic breathlessness in people with progressive life-limiting illnesses.Methods and analysisA total of 240 participants with modified Medical Research Council Dyspnoea Scale breathlessness of level 2 or higher will be randomised to receive either sertraline or placebo for 28 days in this multisite, double-blind study. The dose will be titrated up every 3 days to a maximum of 100 mg daily. The primary outcome will be to compare the efficacy of sertraline with placebo in relieving the intensity of worst breathlessness as assessed by a 0–100 mm Visual Analogue Scale. A number of other outcome measures and descriptors of breathlessness as well as caregiver assessments will also be recorded to ensure adequate analysis of participant breathlessness and to allow an economic analysis to be performed. Participants will also be given the option of continuing blinded treatment until either study data collection is complete or net benefit ceases. Appropriate statistical analysis of primary and secondary outcomes will be used to describe the wealth of data obtained.Ethics and disseminationEthics approval was obtained at all participating sites. Results of the study will be submitted for publication in peer-reviewed journals and the key findings presented at national and international conferences.Trial registration numberACTRN12610000464066.
Quality of interdisciplinary postsimulation debriefing: 360° evaluation
Authors: Hull Louise , Russ Stephanie , Ahmed Maria , Sevdalis Nick , Birnbach David J 
Published: November 2016

IntroductionDebriefing is widely perceived to be the most important component of simulation-based training. This study aimed to explore the value of 360° evaluation of debriefing by examining expert debriefing evaluators, debriefers and learners’ perceptions of the quality of interdisciplinary debriefings.MethodThis was a cross-sectional observational study. 41 teams, consisting of 278 learners, underwent simulation-based team training. Immediately following the postsimulation debriefing session, debriefers and learners rated the quality of debriefing using the validated Objective Structured Assessment of Debriefing (OSAD) framework. All debriefing sessions were video-recorded and subsequently rated by evaluators trained to proficiency in assessing debriefing quality.ResultsExpert debriefing evaluators and debriefers’ perceptions of debriefing quality differed significantly; debriefers perceived the quality of debriefing they provided more favourably than expert debriefing evaluators (40.98% of OSAD ratings provided by debriefers were ≥+1 point greater than expert debriefing evaluators’ ratings). Further, learner perceptions of the quality of debriefing differed from both expert evaluators and debriefers’ perceptions: weak agreement between learner and expert evaluators’ perceptions was found on 2 of 8 OSAD elements (learner engagement and reflection); similarly weak agreement between learner and debriefer perceptions was found on just 1 OSAD element (application).ConclusionsDebriefers and learners’ perceptions of debriefing quality differ significantly. Both groups tend to perceive the quality of debriefing far more favourably than external evaluators. An overconfident debriefer may fail to identify elements of debriefing that require improvement. Feedback provided by learners to debriefers may be of limited value in facilitating improvements. We recommend periodic external evaluation of debriefing quality.
The impact of faults and fluid flow on seismic images of a relay ramp over production time
Authors: Botter Charlotte , Cardozo Nestor , Lecomte Isabelle , Rotevatn Atle , Paton Gaynor 
Published: November 2016

Relay ramps can act as conduits for fluid flow in producing hydrocarbon reservoirs, but the two bounding faults are often at the limit of seismic resolution. To study the impact of relay ramps and their fluid composition on seismic data, we present an integrated workflow combining flow simulation in a geomodel of an outcrop relay ramp, forward seismic modelling and seismic-attribute-based volume extraction. In the chosen outcrop of the Arches National Park (Utah, USA), the petrophysical properties are conditioned by deformation bands present in the sandstone, and are used to run a simple water injector–oil producer fluid-flow simulation. Pre-stack depth-migration seismic images are obtained at
t
= 0,
t
1
= 10 and
t
2
= 20 years of the flow simulation. The seismic image porosity changes at
t
= 0 when the model is oil-saturated, whereas the water–oil contacts have stronger amplitude contrasts at later stages. With an adapted attribute-based workflow, we are able to extract geobodies corresponding to the faults and the relay ramp from the three seismic cubes. By varying workflow parameters, we also show reservoir and acquisition conditions that can affect the resolution of the relay ramp on the seismic image either positively or negatively.
A hydrodynamic model and associated spill-point map for the Huntington Field, UK Central North Sea
Authors: Green Sam , O'Connor Stephen , Swarbrick Richard , Waters Kester 
Published: November 2016

Abstract
The Huntington Field is located in Block UK 22/14b in the UK Central North Sea. The reservoir is the Tertiary Forties Formation (a deep-sea fan interval), which has been produced since 2013. Pre-production well data indicate that hydrocarbons (oil) are present outside structural closure as recorded by direct pressure data and wireline-derived fluid contacts, and indicated by seismic attribute data. These observations in other parts of the world (e.g. Mad Dog Field, Miocene Gulf of Mexico) have been attributed to the presence of a hydrodynamic reservoir. This paper aims to reconcile these observations from seismic data, logs and pressure data with competing models to explain the hydrocarbon distribution.
Combining the interpretations above with the additional observations that (a) there are no sedimentological barriers or identifiable faulting between wells, (b) the surrounding fields (Everest and Forties) have been actively producing for decades, but that calculated flow rates in the Huntington Field agree with published data for other virgin hydrodynamic systems, and (c) measured regional and local overpressure gradients indicate fluid flow to the NW where hydrocarbons are present outside the structure indicates that a hydrodynamic model is the most probable solution to explain the fluids and their present distribution.
Spatial scale and distribution of neurovascular signals underlying decoding of orientation and eye of origin from fMRI data
Authors: Larsson Jonas , Harrison Charlotte , Jackson Jade , Oh Seung-Mock , Zeringyte Vaida 
Published: November 2016

Multivariate pattern analysis of functional magnetic resonance imaging (fMRI) data is widely used, yet the spatial scales and origin of neurovascular signals underlying such analyses remain unclear. We compared decoding performance for stimulus orientation and eye of origin from fMRI measurements in human visual cortex with predictions based on the columnar organization of each feature and estimated the spatial scales of patterns driving decoding. Both orientation and eye of origin could be decoded significantly above chance in early visual areas (V1–V3). Contrary to predictions based on a columnar origin of response biases, decoding performance for eye of origin in V2 and V3 was not significantly lower than that in V1, nor did decoding performance for orientation and eye of origin differ significantly. Instead, response biases for both features showed large-scale organization, evident as a radial bias for orientation, and a nasotemporal bias for eye preference. To determine whether these patterns could drive classification, we quantified the effect on classification performance of binning voxels according to visual field position. Consistent with large-scale biases driving classification, binning by polar angle yielded significantly better decoding performance for orientation than random binning in V1–V3. Similarly, binning by hemifield significantly improved decoding performance for eye of origin. Patterns of orientation and eye preference bias in V2 and V3 showed a substantial degree of spatial correlation with the corresponding patterns in V1, suggesting that response biases in these areas originate in V1. Together, these findings indicate that multivariate classification results need not reflect the underlying columnar organization of neuronal response selectivities in early visual areas. NEW & NOTEWORTHY Large-scale response biases can account for decoding of orientation and eye of origin in human early visual areas V1–V3. For eye of origin this pattern is a nasotemporal bias; for orientation it is a radial bias. Differences in decoding performance across areas and stimulus features are not well predicted by differences in columnar-scale organization of each feature. Large-scale biases in extrastriate areas are spatially correlated with those in V1, suggesting biases originate in primary visual cortex.
Differential effect of visual motion adaption upon visual cortical excitability
Authors: Lubeck Astrid J. A. , Van Ombergen Angelique , Ahmad Hena , Bos Jelte E. , Wuyts Floris L. , Bronstein Adolfo M. , Arshad Qadeer 
Published: November 2016

The objectives of this study were 1) to probe the effects of visual motion adaptation on early visual and V5/MT cortical excitability and 2) to investigate whether changes in cortical excitability following visual motion adaptation are related to the degree of visual dependency, i.e., an overreliance on visual cues compared with vestibular or proprioceptive cues. Participants were exposed to a roll motion visual stimulus before, during, and after visual motion adaptation. At these stages, 20 transcranial magnetic stimulation (TMS) pulses at phosphene threshold values were applied over early visual and V5/MT cortical areas from which the probability of eliciting a phosphene was calculated. Before and after adaptation, participants aligned the subjective visual vertical in front of the roll motion stimulus as a marker of visual dependency. During adaptation, early visual cortex excitability decreased whereas V5/MT excitability increased. After adaptation, both early visual and V5/MT excitability were increased. The roll motion-induced tilt of the subjective visual vertical (visual dependence) was not influenced by visual motion adaptation and did not correlate with phosphene threshold or visual cortex excitability. We conclude that early visual and V5/MT cortical excitability is differentially affected by visual motion adaptation. Furthermore, excitability in the early or late visual cortex is not associated with an increase in visual reliance during spatial orientation. Our findings complement earlier studies that have probed visual cortical excitability following motion adaptation and highlight the differential role of the early visual cortex and V5/MT in visual motion processing. NEW & NOTEWORTHY We examined the influence of visual motion adaptation on visual cortex excitability and found a differential effect in V1/V2 compared with V5/MT. Changes in visual excitability following motion adaptation were not related to the degree of an individual's visual dependency.
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
Authors: Gustafsson Robert , Jemth Ann-Sofie , Gustafsson Nina M.S. , Färnegårdh Katarina , Loseva Olga , Wiita Elisée , Bonagas Nadilly , Dahllund Leif , Llona-Minguez Sabin , Häggblad Maria , Henriksson Martin , Andersson Yasmin , Homan Evert , Helleday Thomas , Stenmark Pål 
Published: November 2016

Abstract
To sustain their proliferation, cancer cells become dependent on one-carbon metabolism to support purine and thymidylate synthesis. Indeed, one of the most highly upregulated enzymes during neoplastic transformation is MTHFD2, a mitochondrial methylenetetrahydrofolate dehydrogenase and cyclohydrolase involved in one-carbon metabolism. Because MTHFD2 is expressed normally only during embryonic development, it offers a disease-selective therapeutic target for eradicating cancer cells while sparing healthy cells. Here we report the synthesis and preclinical characterization of the first inhibitor of human MTHFD2. We also disclose the first crystal structure of MTHFD2 in complex with a substrate-based inhibitor and the enzyme cofactors NAD+ and inorganic phosphate. Our work provides a rationale for continued development of a structural framework for the generation of potent and selective MTHFD2 inhibitors for cancer treatment. Cancer Res; 77(4); 937–48. ©2017 AACR.
Association of Oxidized Low-Density Lipoprotein With Prognosis of Stroke and Stroke Subtypes
Authors: Wang Anxin , Yang Yuling , Su Zhaoping , Yue Wei , Hao Hongjun , Ren Lijie , Wang Yongjun , Cao Yibin , Wang Yilong 
Published: November 2016

Background and Purpose—
The association between oxidized low-density lipoprotein (oxLDL) and the long-term prognosis of stroke is unclear. The aim of this study is to investigate whether oxLDL levels contribute to the prognosis of stroke and stroke subtypes.

Methods—
All patients with ischemic stroke were recruited from the SOS-Stroke (Study of Oxidative Stress in Patients With Acute Ischemic Stroke) and classified into 5 different subtypes, according to the TOAST criteria (Trial of Org 10172 in Acute Stroke Treatment). We measured oxLDL levels and followed up with patients at 1 year after stroke onset. We analyzed the association between oxLDL and the clinical outcomes of death and poor functional outcome (modified Rankin Scale score of 3–6) of stroke and different stroke subtypes.

Results—

Among the 3688 patients included in this study, 293 (7.94%) were deceased at the 1-year follow-up and 1020 (27.66%) had a poor functional outcome. Patients in the highest oxLDL quartile had a higher risk of 1-year stroke mortality (hazard ratio, 1.61; 95% confidence interval, 1.10–2.33;
P
<0.001) and a poor functional outcome (odds ratio, 1.48; 95% confidence interval, 1.15–1.89;
P
<0.001) compared with the lowest oxLDL quartile. In the subgroup analyses, oxLDL was only significantly associated with death and poor functional outcome in the large-artery atherosclerosis subgroup (
P
<0.05) and small-artery occlusion subgroup (
P
<0.05).

Conclusions—
High levels of oxLDL were associated with the high risk of death and poor functional outcome within 1 year after stroke onset, especially in large-artery atherosclerosis and small-artery occlusion stroke subtypes.
Air Pollution Is Associated With Ischemic Stroke via Cardiogenic Embolism
Authors: Chung Jong-Won , Bang Oh Young , Ahn Kangmo , Park Sang-Soon , Park Tai Hwan , Kim Jae Guk , Ko Youngchai , Lee SooJoo , Lee Kyung Bok , Lee Jun , Kang Kyusik , Park Jong-Moo , Cho Yong-Jin , Hong Keun-Sik , Nah Hyun-Wook , Kim Dae-Hyun , Cha Jae-Kwan , Ryu Wi-Sun , Kim Dong-Eog , Kim Joon-Tae , Choi Jay Chol , Oh Mi-Sun , Yu Kyung-Ho , Lee Byung-Chul , Lee Ji Sung , Lee Juneyoung , Park Hong-Kyun , Kim Beom Joon , Han Moon-Ku , Bae Hee-Joon 
Published: November 2016

Background and Purpose—
The aim of the study was to assessed the impact of short-term exposure to air pollution on ischemic stroke subtype, while focusing on stroke caused via cardioembolism.

Methods—

From a nationwide, multicenter, prospective, stroke registry database, 13 535 patients with acute ischemic stroke hospitalized to 12 participating centers were enrolled in this study. Data on the hourly concentrations of particulate matter <10 μm, nitrogen dioxide (NO
2
), sulfur dioxide (SO
2
), ozone (O
3
), and carbon monoxide (CO) were collected from 181 nationwide air pollution surveillance stations. The average values of these air pollutants over the 7 days before stroke onset from nearest air quality monitoring station in each patient were used to determine association with stroke subtype. The primary outcome was stroke subtype, including large artery atherosclerosis, small-vessel occlusion, cardioembolism, and stroke of other or undetermined cause.

Results—

Particulate matter <10 μm and SO
2
concentrations were independently associated with an increased risk of cardioembolic stroke, as compared with large artery atherosclerosis and noncardioembolic stroke. In stratified analyses, the proportion of cases of cardioembolic stroke was positively correlated with the particulate matter <10 μm, NO
2
, and SO
2
quintiles. Moreover, seasonal and geographic factors were related to an increased proportion of cardioembolic stroke, which may be attributed to the high levels of air pollution.

Conclusions—
Our findings suggest that the short-term exposure to air pollutants is associated with cardioembolic stroke, and greater care should be taken for those susceptible to cerebral embolism during peak pollution periods. Public and environmental health policies to reduce air pollution could help slow down global increasing trends of cardioembolic stroke.
Understanding Overland Multisensor Satellite Precipitation Error in TMPA-RT Products
Authors: Gebregiorgis Abebe Sine , Kirstetter Pierre-Emmanuel , Hong Yang E. , Carr Nicholas J. , Gourley Jonathan J. , Petersen Walt , Zheng Yaoyao 
Published: November 2016

Abstract
The Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA) has provided the global community a widely used multisatellite (and multisensor type) estimate of quasi-global precipitation. One of the TMPA level-3 products, 3B42RT/TMPA-RT (where RT indicates real time), is a merged product of microwave (MW) and infrared (IR) precipitation estimates, which attempts to exploit the most desirable aspects of both types of sensors, namely, quality rainfall estimation and spatiotemporal resolution. This study extensively and systematically evaluates multisatellite precipitation errors by tracking the sensor-specific error sources and quantifying the biases originating from multiple sensors. High-resolution, ground-based radar precipitation estimates from the Multi-Radar Multi-Sensor (MRMS) system, developed by the National Severe Storms Laboratory (NSSL), are utilized as reference data. The analysis procedure involves segregating the grid precipitation estimate as a function of sensor source, decomposing the bias, and then quantifying the error contribution per grid. The results of this study reveal that while all three aspects of detection (i.e., hit, missed-rain, and false-rain biases) contribute to the total bias associated with IR precipitation estimates, overestimation bias (positive hit bias) and missed precipitation are the dominant error sources for MW precipitation estimates. Considering only MW sensors, the TRMM Microwave Imager (TMI) shows the largest missed-rain and overestimation biases (nearly double that of the other MW estimates) per grid box during the summer and winter seasons. The Special Sensor Microwave Imagers/Sounders (SSMIS on board F17 and F16) also show major error during winter and spring, respectively.
Prophylactic middle lobe fixation for postoperative pulmonary torsion
Authors: Higashiyama Masahiko , Tokunaga Toshiteru , Kusu Takashi , Ishida Hiroto , Okami Jiro , Kodama Ken 
Published: November 2016

Background To prevent postoperative middle lobe torsion after a right upper lobectomy, we introduced a novel technique of interlobar fixation using collagen fleece coated with fibrin. In this study, the prophylactic effects of this method on the incidence of postoperative pulmonary torsion were analyzed. Methods Between April 2001 and December 2015, 3786 pulmonary resection procedures (excluding total pneumonectomy) were performed in our institution, and prophylactic interlobar fixation was selectively applied when intraoperative examination indicated that the patient was at high risk of postoperative pulmonary lobe torsion. As a control group, 842 patients who underwent pulmonary resection procedures between January 1996 and April 2001 were reviewed. Results During the study period, 10 (0.3%) patients underwent prophylactic middle lobe fixation (to the lower lobe after a right upper lobectomy in 9, and to the upper lobe after a right lower lobectomy in one). Pulmonary lobar (middle lobe) torsion occurred in only one patient (after right upper lobectomy); thus the incidence of this complication was 0.1% among patients who underwent a right upper lobectomy and 0.03% among all pulmonary resection procedures. The rates during the study period were marginally significantly lower than those in the control period (1.3% and 0.24%, respectively; p = 0.071 and p = 0.087, respectively). Conclusion Prophylactic middle lobe fixation might be useful for preventing postoperative pulmonary middle lobe torsion.