bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of maleic anhydride functionalized graphene oxide in improving the interfacial properties of carbon fibre/bismaleimide composites
Authors: Li Wei , Li Qiang , Wang Xiaoqiang , Lu Shaowei , Wang Baichen 
Published: November 2017

AbstractThis work aims to assess the effect of maleic anhydride functionalized graphene oxide (MAH‐f‐GO) on the interfacial properties of carbon fibre/bismaleimide (BMI) composites by experimental and finite element (FE) methods. Transverse fibre bundle (TFB) specimens with different contents of MAH‐f‐GO nanoparticles were manufactured to investigate the interfacial strength of the carbon fibre/BMI composites. The fracture surface of the TFB specimens was examined by scanning electron microscopy to observe the morphologies of the fibre − matrix interface. The coefficient of thermal expansion, cure shrinkage and elastic modulus were measured and included in the FE simulation. An FE analysis model was established to simulate the thermal residual stress distribution around the carbon fibre and to estimate the interfacial bonding strength of the TFB specimens. The combination of experimental and FE analysis results indicated that the addition of MAH‐f‐GO nanoparticles noticeably reduced the concentration of residual stress at the fibre − matrix interface and enhanced the interfacial properties of the carbon fibre/BMI composites.© 2017 Society of Chemical Industry
Blue Native/SDS‐PAGE and iTRAQ‐Based Chloroplasts Proteomics Analysis of Nicotiana tabacum Leaves Infected with M Strain of Cucumber Mosaic Virus Reveals Several Proteins Involved in Chlorosis Symptoms
Authors: Lei Rong , Du Zhixin , Kong Jun , Li Guifen , He Yan , Qiu Yanhong , Yan Jin , Zhu Shuifang 
Published: November 2017

AbstractVirus infection in plants involves necrosis, chlorosis, and mosaic. The M strain of cucumber mosaic virus (M‐CMV) has six distinct symptoms: vein clearing, mosaic, chlorosis, partial green recovery, complete green recovery, and secondary mosaic. Chlorosis indicates the loss of chlorophyll which is highly abundant in plant leaves and plays essential roles in photosynthesis. Blue native/SDS‐PAGE combined with mass spectrum was performed to detect the location of virus, and proteomic analysis of chloroplast isolated from virus‐infected plants was performed to quantify the changes of individual proteins in order to gain a global view of the total chloroplast protein dynamics during the virus infection. Among the 438 proteins quantified, 33 showed a more than twofold change in abundance, of which 22 are involved in the light‐dependent reactions and five in the Calvin cycle. The dynamic change of these proteins indicates that light‐dependent reactions are down‐accumulated, and the Calvin cycle was up‐accumulated during virus infection. In addition to the proteins involved in photosynthesis, tubulin was up‐accumulated in virus‐infected plant, which might contribute to the autophagic process during plant infection. In conclusion, this extensive proteomic investigation on intact chloroplasts of virus‐infected tobacco leaves provided some important novel information on chlorosis mechanisms induced by virus infection.
Inhibition of larval growth and adult fecundity in Asian long‐horned beetle (Anoplophora glabripennis) exposed to azadirachtins under quarantine laboratory conditions
Authors: Thompson Dean G , Tonon Amanda , Beltran Eduardo , Hernandez Felix 
Published: November 2017

AbstractBACKGROUNDThe Asian long‐horned beetle [ALB; Anoplophora glabripennis (Motschulsky)] is an invasive, wood‐boring insect posing significant economic and ecological threats to the deciduous forests of North America. An efficacious and environmentally acceptable chemical control technique is a requirement of a comprehensive, integrated response strategy.RESULTSResults of this study demonstrate statistically significant, concentration‐dependent effects of azadirachtins, a family of natural compounds derived from the neem tree, on both ALB larval and adult life stages. Growth inhibitory effects on ALB larvae were greatest on early life stages. Significant effects on adults included inhibition of female feeding, oviposition effort and fecundity for adults exposed to azadirachtins via maturation feeding on systemically loaded twigs.CONCLUSIONThese quarantine laboratory experiments verify multi‐mechanistic, deleterious effects on both larval and adult life stages of ALB, an exotic, invasive insect pest of critical importance in North America. Field efficacy studies are required to further understand dose acquisition by larval and adult ALB life stages following systemic injections to host trees under semi‐operational use scenarios. Such studies could also be used to test postulates regarding optimal deployment strategies to meet objectives such as slowing the spread of this pest and protection of high‐value deciduous forest resources. © 2017 Her Majesty the Queen in Right of Canada Pest Management Science © 2017 Society of Chemical Industry
First insights into insecticidal activity against Aedes aegypti and partial biochemical characterization of a novel low molecular mass chymotrypsin‐trypsin inhibitor purified from Lonchocarpus sericeus seeds
Authors: Almeida Filho Luiz CP , Tabosa Pedro MS , Hissa Denise C , Vasconcelos Ilka M , Carvalho Ana FU 
Published: November 2017

AbstractBACKGROUNDArboviroses such as dengue, Zika and chikungunya represent a serious public health issue as a consequence of the absence of approved vaccines or specific antiviral drugs against the arboviruses that cause them. One way to prevent these diseases is by combating the vector mosquito, Aedes aegypti (Diptera), which has serine proteases in the midgut. Protease inhibitors are molecules that can block enzyme activity, impairing digestion and nutrition, which can lead to death. Thus, we purified and characterized a novel chymotrypsin‐trypsin inhibitor (LsCTI) from Lonchocarpus sericeus seeds and investigated its effect upon Ae. aegypti egg hatching, larval development and digestive proteases.RESULTSLsCTI showed a single protein band in sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS‐PAGE), and the molecular mass determined by matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry (MALDI‐TOF‐MS) was 8870.45 Da. Kinetics analyses revealed a noncompetitive type of inhibition and low inhibition constant (Ki) for chymotrypsin (8.24 x 10‐8 m). The thermal resistance was remarkable, even at 100 °C for 180 min. The inhibitor concentration required for 50‐percent enzyme inhibition (IC50) of LsCTI was 4.7 x 10‐7 m for Ae. aegypti midgut larval enzymes. LsCTI did not affect egg hatchability at 0.3 mg mL‐1, but caused a high larval mortality rate (77%) and delayed development (37%).CONCLUSIONSLsCTI is a novel protease inhibitor with remarkable biochemical characteristics and is a potential tool to control Ae. aegypti development. © 2017 Society of Chemical Industry
Efficacy and safety of Tripterygium wilfordii Hook F for CKD in Mainland China: A systematic review and meta‐analysis
Authors: Wang Duo , Zhao Xiao‐Han , Cui Yi , Zhang Tian‐Tian , Wang Fang , Hu Yong‐Hong 
Published: November 2017

Tripterygium wilfordii Hook F (TwHF) is a promising Chinese traditional medicine used to significantly reduce proteinuria and improve renal function. However, its efficacy and safety in treatment of chronic kidney disease need to be further explored in order to promote its application in clinics. This review compared the efficacy and safety of TwHF with the placebo, conventional Western medicine and other immunosuppressive medicine in a range of kidney disorders. One hundred three randomized controlled trials were included. TwHF therapy decreased 24‐hr proteinuria by 0.59 g/day (95% confidence interval [CI; −0.68, −0.50]), serum creatinine level by 1.93 μmol/L (95% CI [−3.69, −0.17]), and blood urea nitrogen level by 0.24 mmol/L (95% CI [−0.41, −0.07]); increased the total effective rate by 27% (95% CI [1.24, 1.30]); and decreased the incidence of adverse reactions by 19% (95% CI [0.68, 0.96]) overall. Meta regression results showed that the duration of therapy and mean age of participants were the major sources of high heterogeneity. Sensitivity analysis demonstrated that our statistic results were relatively stable and credible. The present findings suggested that TwHF possibly has nephroprotective effects by decreasing proteinuria, serum creatinine level, and blood urea nitrogen level and no more adverse reactions compared with control group in most kidney disorders. However, these findings still need to be further confirmed by high‐quality trials.
An input‐output linearization–based control strategy for wind energy conversion system to enhance stability
Authors: Liao Kai , Wang Yao , He Zhengyou 
Published: November 2017

AbstractThis paper proposes a novel control strategy for doubly fed induction generator (DFIG)‐based wind energy conversion system to investigate the potential of enhancing the stability of wind energy transmission system, a synchronous generator weakly integrated to a power system with a DFIG‐based wind farm. The proposed approach uses state feedback to exactly linearize the nonlinear wind energy transmission system from control actions (active power and reactive power control order of DFIG) to selected outputs (power angle and voltage behind transient resistance of synchronous generator) at first. Then, on account of the linearized subsystem, the stability enhancement controller is designed based on linear quadratic regulator algorithm to contribute adequate damping characteristics to oscillations of the synchronous generator system under various operation points. The proposed control strategy successfully deals with the nonlinear behaviors exist from the inputs to outputs and improve the robustness with respect to the variation of system operation points. Furthermore, not only the rotor angle stability but also the voltage stability is enhanced by using the proposed control strategy. The simulation results carried on the studied system verify the effectiveness of the proposed control strategy of wind energy conversion system for system stability enhancement and the robustness against various system operation points.
The Survival of the Secret Treaty: Publicity, Secrecy, and Legality in the International Order
Authors: Donaldson Megan 
Published: November 2017

AbstractThis article offers the first detailed history of the norm of treaty publication as it has evolved over the last century. Drawing on both public debates and archives of foreign ministries, it traces how, and why, secret treaties have persisted, even in liberal democracies. It challenges assumptions of ever-greater transparency over time, and complicates the associations made—by interwar reformers and international lawyers today—between the norm of treaty publication and ideals of legality in the international order.
Entrainment across a sheared density interface in a cavity flow
Authors: Williamson N. , Kirkpatrick M. P. , Armfield S. W. 
Published: November 2017

The entrainment of fluid across a sheared density interface has been examined experimentally in a purging cavity flow. In this flow, a long straight cavity with sloped entry and exit boundaries is located in the base of a straight open channel. Dense cavity fluid is entrained from the cavity into the turbulent overflow. The cavity geometry has been designed to ensure there is no separation of the overflow in the cavity region, with the goal of avoiding cavity-specific entrainment mechanisms as have been encountered in most previous experiments using similar arrangements. Results are obtained over a bulk Richardson number range $Ri_{b}=g\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}D/\unicode[STIX]{x1D70C}_{0}U_{b}^{2}=1$ to 19, where $D$ and $U_{b}$ are the depth of the mixed layer and bulk velocity in the cavity, respectively. The experiments cover the Reynolds number range $Re=U_{b}D/\unicode[STIX]{x1D708}=7100$ to 15 100 and interface length to mixed layer depth ratios of 2.4 to 16. Particle image velocimetry and laser induced fluorescence measurements indicate the flow regime over this entire range is one dominated by the Holmboe wave instability. The non-dimensional entrainment rate, $E=u_{e}/U_{b}$, is shown to scale with the bulk Richardson number. We find that the entrainment scaling $E=CRi_{b}^{-1.38}$ applies over the entire experimental range, with no apparent dependence on interface length. The exponent in the scaling is similar to previous non-cavity-based sheared interface flows, however, the constant $C$ is up to an order of magnitude smaller. Close agreement is, however, obtained by instead correlating entrainment with the local gradient Richardson number centred on the interface, rather than bulk quantities. We obtain $E=0.0021Ri_{g}^{-0.63}$ for data over $10<Ri_{g}<50$, where $Ri_{g}=\langle g\unicode[STIX]{x2202}\unicode[STIX]{x1D70C}/\unicode[STIX]{x1D70C}_{0}\unicode[STIX]{x2202}z\rangle /\langle (\unicode[STIX]{x2202}U/\unicode[STIX]{x2202}z)^{2}\rangle$. The density interface is much thinner and therefore more stable in the present flow configuration compared with other published results for the same bulk Richardson number. We suggest that our configuration ensures a sharp mixing layer profile at the upstream end of the cavity even at relatively low bulk Richardson numbers of $Ri_{b}=1$ and that the reduced mixing in the Holmboe wave regime allows the interface to retain its sharp character over the cavity length, resulting in weak sensitivity to cavity length.
Effect of aggregation form on bioavailability of zeaxanthin in humans: a randomised cross-over study
Authors: Hempel Judith , Fischer Anja , Fischer Monique , Högel Josef , Bosy-Westphal Anja , Carle Reinhold , Schweiggert Ralf M. 
Published: November 2017

AbstractCarotenoid bioavailability from plant and animal food is highly variable depending on numerous factors such as the physical deposition form of carotenoids. As the carotenoid zeaxanthin is believed to play an important role in eye and brain health, we sought to compare the human bioavailability of an H-aggregated with that of a J-aggregated deposition form of zeaxanthin encapsulated into identical formulation matrices. A randomised two-way cross-over study with sixteen participants was designed to compare the post-prandial bioavailability of an H-aggregated zeaxanthin and a J-aggregated zeaxanthin dipalmitate formulation, both delivering 10 mg of free zeaxanthin. Carotenoid levels in TAG-rich lipoprotein fractions were analysed over 9·5 h after test meal consumption. Bioavailability from the J-aggregated formulation (AUC=55·9 nmol h/l) was 23 % higher than from the H-aggregated one (AUC=45·5 nmol h/l), although being only marginally significant (P=0·064). Furthermore, the same formulations were subjected to an internationally recognisedin vitrodigestion protocol to reveal potential strengths and weaknesses of simulated digestions. In agreement with our human study, liberation of zeaxanthin from the J-aggregated formulation into the simulated duodenal fluids was superior to that from the H-aggregated form. However, micellization rate (bioaccessibility) of the J-aggregated zeaxanthin dipalmitate was lower than that of the H-aggregated zeaxanthin, being contradictory to ourin vivoresults. An insufficient ester cleavage during simulated digestion was suggested to be the root cause for these observations. In brief, combining ourin vitroandin vivoobservations, the effect of the different aggregation forms on human bioavailability was lower than expected.
Pathogens collections, biobanks and related-data in a One Health legal and ethical perspective
Authors: LAJAUNIE CLAIRE , HO CALVIN WAI-LOON 
Published: November 2017

SUMMARYResearch on emerging infectious diseases calls for a work on collections of pathogens (including hosts or vectors from which the pathogens were isolated), related to human and animal health, to wildlife or on the environmental material. In this respect, the adoption of a One Health perspective is determined by the need for a common approach to consider the collection, storage and use of pathogens coming from human or non-human sources, and particularly when the same pathogen is taken from different environments. In response to this development, our purpose is to delineate a flexible regulation framework concerning collections of pathogens from various origins or hosts and their associated data in order to facilitate scientific work and research partnerships. The legal and ethical cutting-edge research on Biomedical Big Data is particularly stimulating when it comes to address challenges related to collections or biobanks of pathogens such as prior informed consent and accessibility, Material Transfer Agreement or benefit sharing.
The physiological constellation of deprivation: Immunological strategies and health outcomes
Authors: Garcia Angela R. , Blackwell Aaron D. 
Published: November 2017

AbstractPhysiology and behavior are best thought of as two aspects of the same biological process, shaped simultaneously by natural selection. Like behavioral strategies, ecological conditions may affect physiological strategies, leading to changes in immunity and hormonal regulation. These alternate strategies help explain the health correlations of deprivation and provide additional pathways for feedback from early-life experiences.
Stuff goes wrong, so act now
Authors: Riis-Vestergaard Michala Iben , Haushofer Johannes 
Published: November 2017

AbstractPepper & Nettle make an ambitious and compelling attempt to isolate a common cause of what they call the behavioral constellation of deprivation. We agree with the authors that limited control can indeed help explain part of the difference in observed present-oriented behavior between the poor and the rich. However, we suggest that mortality risk is not the primary mechanism leading to this apparent impatience.
Art reception as an interoceptive embodied predictive experience
Authors: Azevedo Ruben T. , Tsakiris Manos 
Published: November 2017

AbstractIn the Distancing-Embracing model, an explanation is proposed for the apparent paradox that is the enjoyment of negative emotional states in art reception. Here, we argue for the advantages of grounding the psychological dynamics described in the model in established and empirically testable frameworks of brain functioning by thinking of art reception as an embodied experience guided by predictive coding.
Explaining the enjoyment of negative emotions evoked by the arts: The need to consider empathy and other underlying mechanisms of emotion induction
Authors: Vuoskoski Jonna K. , Eerola Tuomas 
Published: November 2017

AbstractAny model aiming to explain the enjoyment of negative emotions in the context of the arts should consider how works of art are able to induce emotional responses in the first place. For instance, research on empathy and the arts suggests that the psychological processes that mediate the enjoyment of sadness and horror may be fundamentally different.
Kantian Dignity and Marxian Socialism
Authors: Gilabert Pablo 
Published: November 2017

AbstractThis article offers an account of human dignity based on a discussion of Kant’s moral and political philosophy and then shows its relevance for articulating and developing in a fresh way some normative dimensions of Marx’s critique of capitalism as involving exploitation, domination and alienation, and the view of socialism as involving a combination of freedom and solidarity. What is advanced here is not Kant’s own conception of dignity, but an account that partly builds on that conception and partly criticizes it. The same is the case with the account of socialism in relation to Marx’s work. As articulated, Kantian dignity and Marxian socialism turn out to be quite appealing and mutually supportive.
Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
Authors: Watson C. T. , Cohain A. T. , Griffin R. S. , Chun Y. , Grishin A. , Hacyznska H. , Hoffman G. E. , Beckmann N. D. , Shah H. , Dawson P. , Henning A. , Wood R. , Burks A. W. , Jones S. M. , Leung D. Y. M. , Sicherer S. , Sampson H. A. , Sharp A. J. , Schadt E. E. , Bunyavanich S. 
Published: November 2017

AbstractMechanisms driving acute food allergic reactions have not been fully characterized. We profile the dynamic transcriptome of acute peanut allergic reactions using serial peripheral blood samples obtained from 19 children before, during, and after randomized, double-blind, placebo-controlled oral challenges to peanut. We identify genes with changes in expression triggered by peanut, but not placebo, during acute peanut allergic reactions. Network analysis reveals that these genes comprise coexpression networks for acute-phase response and pro-inflammatory processes. Key driver analysis identifies six genes (LTB4R,PADI4,IL1R2,PPP1R3D,KLHL2, andECHDC3) predicted to causally modulate the state of coregulated networks in response to peanut. Leukocyte deconvolution analysis identifies changes in neutrophil, naive CD4+T cell, and macrophage populations during peanut challenge. Analyses in 21 additional peanut allergic subjects replicate major findings. These results highlight key genes, biological processes, and cell types that can be targeted for mechanistic study and therapeutic targeting of peanut allergy.
Genome-wide DNA methylation changes associated with olfactory learning and memory in Apis mellifera
Authors: Li You , Zhang Li-Zhen , Yi Yao , Hu Wan-Wan , Guo Ya-Hui , Zeng Zhi-Jiang , Huang Zachary-Y. , Wang Zi-Long 
Published: November 2017

AbstractThe honeybee is a model organism for studying learning and memory formation and its underlying molecular mechanisms. While DNA methylation is well studied in caste differentiation, its role in learning and memory is not clear in honeybees. Here, we analyzed genome-wide DNA methylation changes during olfactory learning and memory process in A. mellifera using whole genome bisulfite sequencing (WGBS) method. A total of 853 significantly differentially methylated regions (DMRs) and 963 differentially methylated genes (DMGs) were identified. We discovered that 440 DMRs of 648 genes were hypermethylated and 274 DMRs of 336 genes were hypomethylated in trained group compared to untrained group. Of these DMGs, many are critical genes involved in learning and memory, such as Creb, GABA
B
R and Ip3k, indicating extensive involvement of DNA methylation in honeybee olfactory learning and memory process. Furthermore, key enzymes for histone methylation, RNA editing and miRNA processing also showed methylation changes during this process, implying that DNA methylation can affect learning and memory of honeybees by regulating other epigenetic modification processes.