bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Trial of Hepatic Artery Embolization for Hepatocellular Carcinoma Using Doxorubicin-Eluting Microspheres Compared With Embolization With Microspheres Alone
Authors: Brown Karen T. , Do Richard K. , Gonen Mithat , Covey Anne M. , Getrajdman George I. , Sofocleous Constantinos T. , Jarnagin William R. , D’Angelica Michael I. , Allen Peter J. , Erinjeri Joseph P. , Brody Lynn A. , O’Neill Gerald P. , Johnson Kristian N. , Garcia Alessandra R. , Beattie Christopher , Zhao Binsheng , Solomon Stephen B. , Schwartz Lawrence H. , DeMatteo Ronald , Abou-Alfa Ghassan K. 
Published: February 2016

Purpose Transarterial chemoembolization is accepted therapy for hepatocellular carcinoma (HCC). No randomized trial has demonstrated superiority of chemoembolization compared with embolization, and the role of chemotherapy remains unclear. This randomized trial compares the outcome of embolization using microspheres alone with chemoembolization using doxorubicin-eluting microspheres. Materials and Methods At a single tertiary referral center, patients with HCC were randomly assigned to embolization with microspheres alone (Bead Block [BB]) or loaded with doxorubicin 150 mg (LC Bead [LCB]). Random assignment was stratified by number of embolizations to complete treatment, and assignments were generated by permuted blocks in the institutional database. The primary end point was response according to RECIST 1.0 (Response Evaluation Criteria in Solid Tumors) using multiphase computed tomography 2 to 3 weeks post-treatment and then at quarterly intervals, with the reviewer blinded to treatment allocation. Secondary objectives included safety and tolerability, time to progression, progression-free survival, and overall survival. This trial is currently closed to accrual. Results Between December 2007 and April 2012, 101 patients were randomly assigned: 51 to BB and 50 to LCB. Demographics were comparable: median age, 67 years; 77% male; and 22% Barcelona Clinic Liver Cancer stage A and 78% stage B or C. Adverse events occurred with similar frequency in both groups: BB, 19 of 51 patients (38%); LCB, 20 of 50 patients (40%; P = .48), with no difference in RECIST response: BB, 5.9% versus LCB, 6.0% (difference, −0.1%; 95% CI, −9% to 9%). Median PFS was 6.2 versus 2.8 months (hazard ratio, 1.36; 95% CI, 0.91 to 2.05; P = .11), and overall survival, 19.6 versus 20.8 months (hazard ratio, 1.11; 95% CI, 0.71 to 1.76; P = .64) for BB and LCB, respectively. Conclusion There was no apparent difference between the treatment arms. These results challenge the use of doxorubicin-eluting beads for chemoembolization of HCC.
Patient Prognostic Score and Associations With Survival Improvement Offered by Radiotherapy After Breast-Conserving Surgery for Ductal Carcinoma In Situ: A Population-Based Longitudinal Cohort Study
Authors: Sagara Yasuaki , Freedman Rachel A. , Vaz-Luis Ines , Mallory Melissa Anne , Wong Stephanie M. , Aydogan Fatih , DeSantis Stephen , Barry William T. , Golshan Mehra 
Published: February 2016

Purpose Radiotherapy (RT) after breast-conserving surgery (BCS) is a standard treatment option for the management of ductal carcinoma in situ (DCIS). We sought to determine the survival benefit of RT after BCS on the basis of risk factors for local recurrence. Patients and Methods A retrospective longitudinal cohort study was performed to identify patients with DCIS diagnosed between 1988 and 2007 and treated with BCS by using SEER data. Patients were divided into the following two groups: BCS+RT (RT group) and BCS alone (non-RT group). We used a patient prognostic scoring model to stratify patients on the basis of risk of local recurrence. We performed a Cox proportional hazards model with propensity score weighting to evaluate breast cancer mortality between the two groups. Results We identified 32,144 eligible patients with DCIS, 20,329 (63%) in the RT group and 11,815 (37%) in the non-RT group. Overall, 304 breast cancer–specific deaths occurred over a median follow-up of 96 months, with a cumulative incidence of breast cancer mortality at 10 years in the weighted cohorts of 1.8% (RT group) and 2.1% (non-RT group; hazard ratio, 0.73; 95% CI, 0.62 to 0.88). Significant improvements in survival in the RT group compared with the non-RT group were only observed in patients with higher nuclear grade, younger age, and larger tumor size. The magnitude of the survival difference with RT was significantly correlated with prognostic score (P < .001). Conclusion In this population-based study, the patient prognostic score for DCIS is associated with the magnitude of improvement in survival offered by RT after BCS, suggesting that decisions for RT could be tailored on the basis of patient factors, tumor biology, and the prognostic score.
Cervical Length and Androgens in Pregnant Women With Polycystic Ovary Syndrome: Has Metformin Any Effect?
Authors: Shetelig Løvvik Tone , Stridsklev Solhild , Carlsen Sven M. , Salvesen Øyvind , Vanky Eszter 
Published: February 2016

Abstract

Context:
Women with polycystic ovary syndrome (PCOS) have increased risk of preterm delivery. Shortening of the cervix is a sign of preterm delivery.

Objective:
This study aimed to investigate potential effect of metformin on cervical length and whether androgen levels correlate with cervical length in PCOS pregnancies.

Design and Setting:
This was a sub-study of a randomized, placebo-controlled, multicenter study (The PregMet study) performed at 11 secondary or tertiary centers from 2005 to 2009.

Participants:
Two-hundred sixty-one pregnancies of 245 women with PCOS, age 18–42 years participated.

Interventions:
Participants were randomly assigned to metformin or placebo from first trimester to delivery.

Outcome Measurements:
We compared cervical length and androgen levels in metformin and placebo groups at gestational weeks 19 and 32. We also explored whether cervical length correlated with androgen levels.

Results:
We found no difference in cervical length between the metformin and the placebo groups at gestational week 19 and 32. Dehydroepiandrosterone (DHEAS) tended to be higher in the metformin group. There were no correlations between androgens and cervical length at week 19. At gestational week 32, androstenedione (P = .02) and DHEAS (P = .03) showed a trend toward negative correlation to cervical length. High androstenedione level correlated with shortening of cervical length from week 19 to 32 when adjusted for confounders (P = .003). T (P = .03), DHEAS (P = .02), and free testosterone index (P = .03) showed a similar trend.

Conclusion:
Metformin in pregnancy did not affect cervical length in women with PCOS. High maternal androgen levels correlated with cervical shortening from the second to the third trimester of pregnancy, as a sign of cervical ripening.
LYR study: Influence of a web-based application on the systematic chronological and effectiveness of network-guided patient management processes in lymphological care
Authors: Berger J. , Rahms V. , Uhlemann H. , Waldvogel-Röcker K. , Hahn S. 
Published: February 2016

SummaryThe systematic acquisition of data for proving the benefit of standard treatment, demonstrating the efficiency of treatment provided by interprofessional patient management processes and providing valid epidemiological data is inadequate or even nonexistent in the treatment of lymphological disorders. The LYR study firstly uses a webbased documentation tool to examine whether treatment quality is ensured under the conditions provided by an outpatient lymph network that has been guaranteed by a systematic and guideline-compliant treatment analogy. The study evaluated the introduction and handling of a web-based documentation platform for joint case management. LYR also stands synonymously for Lymph Register, and represents a feasibility study with regard to establishing a national lymph register. A phase 1 multicentre interventional study of complex physical decongestion therapy on 61 subjects with different lymphological disorders investigated the immediate and late effects of a prespecified treatment analogy and web-based data acquisition with interdisciplinary data access in six regional lymph networks. Findings on the changes to quality of life and on the effect of the frequency of manual lymphatic drainage and the height of lymphological compression bandages on the results of decongestion were documented and data on prescribing periods and the behaviour of cost bearers were acquired. The study results show that a web-based, structured documentation system can usefully support treatment regimens and simplify mutual access to the patient management process. The epidemiological data acquired during the evaluation of the findings sheet are completely new in Germany and are seen as a feasibility study for a national lymph register that is being prepared. LYR also shows that standard treatment (CPD) has positive effects on circumferences, quality of life, and mobility. It was also shown that a high frequency of manual lymph drainage shortened the decongestion treatment period.
Clostridium difficile-associated diarrhoea in primary joint arthroplasty in Aneurin Bevan University Health Board South
Authors: Blocker O , Abdulkadir U , Roberts P 
Published: February 2016

Introduction The choice of perioperative antibiotics to reduce the prevalence of infection after joint arthroplasty should be considered carefully to minimise the risk of nosocomial infections. Dramatic increases in the incidence and severity of healthcare-associated Clostridium difficile infection with Clostridium difficile-associated diarrhoea (CDAD) have occurred since 2000. Methods A retrospective audit of patients who underwent total hip and total knee replacement between 1 January 2005 and 31 December 2007 was undertaken in Aneurin Bevan University Health Board South (ABHBS). Stool samples from patients who had diarrhoea <12 months of surgery were recorded. Positive samples for CDAD <1 month of surgery were identified. After the change in practice in June 2010, a re-audit linked joint-replacement patients between 1 July 2010 and 26 June 2013 with infection control-records for CDAD-positive cases. Results In the first audit cycle, 1900 joint procedures were carried out in 1845 patients. There were 4 cases of CDAD <1 month of surgery (0.22%). In the re-audit period, 2591 joint procedures were undertaken in 2400 patients: no cases of CDAD <1 month of surgery were recorded. Fisher’s exact test gave a two-tailed p=0.036. Conclusions The significant reduction in CDAD cases after the change in perioperative antibiotic regimen for primary joint arthroplasty mirrored a 66% reduction in overall CDAD cases in the ABUHBS between 2008 and 2012. This reduction was accompanied by financial savings in antibiotics and nursing hours.
Capability of Catfish (Clarias gariepinus) to Accumulate Hg2+ From Water
Authors: Suseno Heny 
Published: February 2016

Mercury is hazardous contaminant that can be accumulated by aquatic organisms such as fishes, mussels etc. Catfish is one of source of animal protein but it also can accumulate Hg2+ from water that used in aquaculture. Due to less information about capability of catfish to accumulate Hg2+, therefore we studied bioaccumulation of Hg2+ that used biokinetic approach (aqueous uptake-rate, and elimination-rate). Nuclear application technique was applied in this study by using radiotracer of 203Hg. A simple kinetic model was then constructed to predict the bioaccumulation capability of by catfish. The result of experiments were shown that the uptake rate of difference Hg2+ concentration were 79.90 to 101.22 ml.g-1.d-1. Strong correlation between uptake rates with increasing Hg2+concentration. In addition, the elimination rates were range 0.080 – 0.081 day-1. The biology half time (t1/2b) of Hg2+ in whole body catfish were 8.50 – 8.63 days. However, no clear correlation between elimination rate with increasing concentration of Hg2+. The calculation of Bio Concentration Factor (BCF) shown catfish have capability to accumulated Hg maximum 1242.69 time than its concentration in water
Effects of Indole-3-Acetic Acid on Germination in Lead Polluted Petri Dish of Citrullus lanatus (Thunberg) Matsumura and Nakai, Cucurbitaceae
Authors: Ogwu Matthew Chidozie , Osas Aiwansoba Raymond , Edwin Osawaru Moses 
Published: February 2016

Watermelon, Citrullus lanatus (Thunberg) Matsumura and Nakai is a tropical fruit vegetable. Indole-3-acetic acid (IAA) is a popular phytohormone while lead (Pb) is a common environmental pollutant in urban and sub-urban centers. C. lanatus were obtained from Benin City with a view to study the effects of IAA on their germination in Pb polluted environment. Germination percentage without IAA and Pb treatment in petri dish was significant after ten days. Hastened germination was observed when IAA and lead were used. About 100 % germination was recorded after seven days. This suggests that water melon seeds can initiate growth even in lead polluted environment. Optimum level of 5 ppm IAA with the different levels of lead treatments may be recommended. Most important was that higher concentrations of Pb in the control (without IAA) did not inhibit seedling shoot nor root growth. Longest seedling shoot length (cm) was 10.33 ± 1.24 and 12.13 ± 2.06 on the seventh and eighth day respectively with the combined treatment levels of 1 ppm IAA and 15 ppm Pb. On the ninth day, 15.27 ± 0.96 was obtained from 1 ppm IAA and 20 ppm Pb. Longest seedling root length (cm) values were recorded from the combined treatment levels of 0 ppm IAA and 10 ppm Pb for the seventh (9.10 ± 0.47) and ninth (10.37 ± 1.81) day respectively and 0 ppm and 15 ppm Pb on the eighth (9.37 ± 0.84) day. Significant means were also obtained with the treatment level of 0 and 20 ppm IAA. This present study suggest the germination of C. lanatus under Pb polluted environment may be rescued with optimum IAA.
Work ethics: On fair labour practices in a socially engaged art world
Authors: Enigbokan Adeola 
Published: January 2016

Abstract
This article shifts the conversation around ethics in social practice art from a focus on individual artist’s engagements with particular communities towards a critical exploration of the discursive practices that are bringing ‘socially engaged art’ into being as a field. Drawing from social theories of work and labour, and traditions of institutional critique in art practice, along with providing an analysis of the author’s own artistic research projects in Moscow and New York, this article addresses the ethical implications of the means by which socially engaged art is produced as a profession, or a form of skilled labour. The article presents socially engaged art as defined by particular habitual interactions, often within the context of institutions, and proposes practical ways by which to address ethics in the production of socially engaged art.
Social practice or Trojan horse? The need for an ethical framework to guide art in the public sphere
Authors: Wilson Risë 
Published: January 2016

Abstract
The twenty-first century has seen a burgeoning swell of artists seeking to make a difference/to engage with their neighbours/or with someone else’s neighbours/to be activists/to be urban planners/to ‘make places’ and ‘build bridges’/to connect more directly with the people who would otherwise serve as anonymous audience to their work. But among those notable ambitions, what is painfully absent is an ethical framework to guide all involved. Artists who have been doing this kind of work for generations may bring with them a personal history of being radicalized and mentored in justice- and community-based work. But an adequate compass is missing for those who are endeavouring to make a positive change, equipped with skill sets derived from MFA programmes and their personal supplies of empathy. The absence of a shared set of professional ethics, or at least a standard set of questions for all involved to consider, stands in the way of good practice and ultimately the larger goal of creating a better world sought by these artists and their projects. Exploring issues of power and privilege, collective generosity, and the full range of support needed for artists and communities to work together equitably and effectively, this article introduces a range of instances where ethics are implicated but too often are missing.
‘Strange times to be a chicken’: The meaning of a metaphor
Authors: Chyutin Dan 
Published: February 2016

Abstract
This article addresses Cock Fight’s displacement of the Judaic metaphor of ‘sacrificial chicken’ onto the Palestinian, and its simultaneous reimagining of the Jew as a victimizing ‘cock’. Concurrently, it discusses the problematic implications of the film’s use of actual chickens as metaphors, which subverts its anti-exploitation political agenda.
Cock Fight: The limits of psychology
Authors: Krasner Michael 
Published: February 2016

Abstract
This well-made, engaging film depicts the Israeli Palestinian conflict as a struggle between individuals, emphasizing the attitudes – stubbornness, pride, racism, machismo – that prevent peace-making. While illuminating key aspects of the situation, this psychological approach avoids the essential political dimensions, the all-too-real conflicts of interest, both material and moral.
Of Palestinian roadblocks: Changing attitudes among Israeli Jews
Authors: Sasley Brent E. 
Published: February 2016

Abstract
Cock Fight explores what happens when Israelis lose the controlling power that comes with occupation of Palestinian territory. Its portrayal of the Israeli reaction to Palestinian power – naiveté, anger, helplessness, resignation – tracks general attitudes among Israeli Jews over time, anticipating in many ways the desire for complete separation from Palestinians.
Cock Fight – A 2015 reading
Authors: Hermann Tamar S. 
Published: February 2016

Abstract
The article analyzes the 1999 short film Cock Fight from a 2015 perspective. It argues that in the late 1990s its ending seemed pessimistic. However, in retrospect, with the total collapse of trust between Israelis and Palestinians, the way out of the encounter at the checkpoint looks almost desirable.
Spaces of transition and framed passages in a sphere of conflict
Authors: Westgeest Helen 
Published: February 2016

Abstract
Framed passages in Draft, such as doorways, mirrors and windows, function as barriers. They stress the unstable equilibrium between spaces and the deep senses of loneliness of the protagonists, thus underscoring both physical and emotional dimensions. In the past, painters also applied these strategies to infuse their art with layered meanings.
Trāṯaka: A case of study on seamless interaction with BCI
Authors: Chierico Alessio 
Published: February 2016

Abstract
Trāṯaka is an interactive installation based on a brain-computer interface (BCI). Wearing this device, the user is invited to concentrate his attention on a flame placed in front of him, in order to extinguish the fire. This work is here presented as a case study about seamless interaction. According to the feedback provided by the users, Trāṯaka stimulates two main kinds of reactions: on the one side, scepticism, and, on the other, enthusiasm. In the first case, there is a clear mistrust on the functioning of this technology. In the second case, there is a blind trust in the system that is perceived as magic. However, here, both these reactions are considered wrong. They share a basic and comprehensible misunderstanding of the system, because its interface aims to be invisible during the interaction. Interfaces that tend towards invisibility do not provide enough information about the system, alimenting misunderstandings and folk theories. In opposition, it is here discussed that design methodologies related to the ideas of Enactivism, Embodied Interaction and Material Engagement propose interaction strategies that involve the whole body-mind knowledge.
The onion pie as souvenir: The in between of writing as a space of meeting the other
Authors: Dürig Regina 
Published: February 2016

Abstract
This article explores the longing, the heterotopian structure of distance and proximity in literary writing. It proposes the two short stories The Red Notebook by Paul Auster and St. Martin by Lydia Davis as a starting point for the reflections on what is there and not there at the same time. The differences between the two narratives are discussed from a writer’s perspective, the distance and proximity is measured with literary means.
Fields of networked mind: Ritual consciousness and the factor of communitas in networked rites of compassion
Authors: Moore Lila 
Published: February 2016

Abstract
Ritual consciousness is an altered state of consciousness that transpires beyond the boundaries of the known and gives rise to a duration referred to as time out of time. This extraordinary duration encompasses three interrelated factors: digital as opposed to analogue conduct of time, tempo and communitas. Under specific formal conditions, these factors may emerge in the context of networked rituals and outside their traditional and earthbound religious or spiritual settings. In this article, the three factors are analysed in relation to the author’s networked rites on the Waterwheel platform. The rites are designed to explore ritual consciousness and produce prototype morphic fields of compassion, which are aimed at counteracting the prevalent narrative of violence. There is an emphasis on communitas, a liminal and nonhierarchical communal state of oneness that could generate compassion. Based on researches in anthropology, biogenetic structuralism, cognitive neuroscience and morphic resonance, communitas is metaphorically envisioned as the communion of non-local brains within a networked mind and morphic field. The article postulates that the virtual and organic hybridity of the rites involve the participants’ body, brain and fields of the mind in the explorations of ritual consciousness.
Undivided light
Authors: Riskin Seth 
Published: February 2016

Abstract
Light as a subject of thought has proved impossible to deal with holistically. Light is intrinsic to the farthest reaches of physics, psychology, philosophy, art, etc. The conceptual structures to deal with light have been quite complex, often resulting in contradictions and paradoxes, e.g., light is conceived in terms of space and time, themselves functions of light. Knowing light appears to leave a remainder. Light cannot be wholly captured by thought; the experience of light does not reduce to knowledge of light. Perhaps more than any other phenomenon, light poses problems of distinguishing between the physical object and the object in mind. The record of thought about light shows that distinguishing between subjective and objective aspects of light has been notoriously difficult and a recurrent effort, apparently necessary towards understanding light. The author argues that light demands the reconciliation of concept and experience, objective and subjective aspects; dividing these limits understanding of light. In developing a research method that combines both the semantics and architectonics of light, the author draws from his original Light Dance art form towards a holistic understanding of light that reflects mindmatter continuity.