bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultimate Toughness of Polypropylene Reactor Copolymer Blends under Impact Conditions, the Role of Morphology
Authors: Deblieck Rudy A. C. , Remerie Klaas 
Published: June 2017

SummaryThe role of rubber particle size, − distribution, and the constitutive behaviour of the isotactic Polypropylene matrix has been studied by combining the Lazerri‐Dompas energy criterion for cavitation and the Van der Sanden, Meier, Tervoort ligament model, adapted for impact conditions. It is concluded that optimising the morphology offers great potential to achieve ultimate properties with far less rubber and hence achieve a superior Stiffness‐Toughness‐Processing balance.
Combination of citrus polymethoxyflavones, green tea polyphenols, and Lychee extracts suppresses obesity and hepatic steatosis in high‐fat diet induced obese mice
Authors: Pan Min‐Hsiung , Yang Guliang , Li Shiming , Li Ming‐Yi , Tsai Mei‐Ling , Wu Jia‐Ching , Badmaev Vladimir , Ho Chi‐Tang , Lai Ching‐Shu 
Published: June 2017

ScopeSlimTrym® is a formulated product composed of citrus polymethoxyflavones (PMFs), green tea extract, and lychee extract. We investigated the effect of dietary SlimTrym® on diet‐induced obesity and associated non‐alcoholic fatty liver disease (NAFLD) in mice.Methods and resultsMale C57BL/6 mice were fed a normal diet (ND), high fat diet (HFD) or HFD containing 0.1% or 0.5% SlimTrym® for 16 weeks. Dietary SlimTrym® significantly reduced weight gain and relative perigonadal, retroperitoneal, mesenteric fat weight as well as the size of adipocyte in HFD‐fed mice. SlimTrym® supplementation also effectively diminished hepatic steatosis and the serum levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), triacylglycerol (TG), and total cholesterol (TCHO). Down‐regulation of peroxisome proliferator‐activated receptor (PPAR)γ, sterol regulatory element‐binding protein (SREBP)‐1, and the activation of AMP‐activated protein kinase (AMPK) signaling by SlimTrym® in both adipose tissue and liver may be responsible for the observed anti‐obesity effects.ConclusionSlimTrym® supplementation potentially diminished diet‐induced obesity and hepatic steatosis via regulating AMPK signaling and molecules involved in lipid metabolism.
Supplement 2 for the 2004 update of theAAPMTask Group No. 43 Report: Joint recommendations by theAAPMandGEC‐ESTRO
Authors: Rivard Mark J. , Ballester Facundo , Butler Wayne M. , DeWerd Larry A. , Ibbott Geoffrey S. , Meigooni Ali S. , Melhus Christopher S. , Mitch Michael G. , Nath Ravinder , Papagiannis Panagiotis 
Published: June 2017

Since the publication of the 2004 update to the American Association of Physicists in Medicine (AAPM) Task Group No. 43 Report (TG‐43U1) and its 2007 supplement (TG‐43U1S1), several new low‐energy photon‐emitting brachytherapy sources have become available. Many of these sources have satisfied theAAPMprerequisites for routine clinical purposes and are posted on the Brachytherapy Source Registry managed jointly by theAAPMand the Imaging and Radiation Oncology Core Houston Quality Assurance Center (IROCHouston). Given increasingly closer interactions among physicists in North America and Europe, theAAPMand the Groupe Européen de Curiethérapie‐European Society for Radiotherapy & Oncology (GEC‐ESTRO) have prepared another supplement containing recommended brachytherapy dosimetry parameters for eleven low‐energy photon‐emitting brachytherapy sources. The current report presents consensus datasets approved by theAAPMandGEC‐ESTRO. The following sources are included:125I sources (BEBIGmodel I25.S17,BEBIGmodel I25.S17plus,BEBIGmodel I25.S18, Elekta model 130.002, Oncura model 9011, and Theragenics model AgX100);103Pd sources (CivaTech Oncology modelCS10,IBt model 1031L,IBt model 1032P, and IsoAid modelIAPd‐103A); and131Cs (IsoRay Medical modelCS‐1 Rev2). Observations are included on the behavior of these dosimetry parameters as a function of radionuclide.Recommendations are presented on the selection of dosimetry parameters, such as from societal reports issuing consensus datasets (e.g.,TG‐43U1,AAPMReport #229), the jointAAPM/IROCHouston Registry, theGEC‐ESTROwebsite, the Carleton University website, and those included in software releases from vendors of treatment planning systems. Aspects such as timeliness, maintenance, and rigor of these resources are discussed.Links to reference data are provided for radionuclides (radiation spectra and half‐lives) and dose scoring materials (compositions and mass densities). The recent literature is examined on photon energy response corrections for thermoluminescent dosimetry of low‐energy photon‐emitting brachytherapy sources. Depending upon the dosimetry parameters currently used by individual physicists, use of these recommended consensus datasets may result in changes to patient dose calculations. These changes must be carefully evaluated and reviewed with the radiation oncologist prior to their implementation.
The effect of concomitant fields in fast spin echo acquisition on asymmetric MRI gradient systems
Authors: Tao Shengzhen , Weavers Paul T. , Trzasko Joshua D. , Huston John , Shu Yunhong , Gray Erin M. , Foo Thomas K.F. , Bernstein Matt A. 
Published: June 2017

PurposeTo investigate the effect of the asymmetric gradient concomitant fields (CF) with zeroth and first‐order spatial dependence on fast/turbo spin‐echo acquisitions, and to demonstrate the effectiveness of their real‐time compensation.MethodsAfter briefly reviewing the CF produced by asymmetric gradients, the effects of the additional zeroth and first‐order CFs on these systems are investigated using extended‐phase graph simulations. Phantom and in vivo experiments are performed to corroborate the simulation. Experiments are performed before and after the real‐time compensations using frequency tracking and gradient pre‐emphasis to demonstrate their effectiveness in correcting the additional CFs. The interaction between the CFs and prescan‐based correction to compensate for eddy currents is also investigated.ResultsIt is demonstrated that, unlike the second‐order CFs on conventional gradients, the additional zeroth/first‐order CFs on asymmetric gradients cause substantial signal loss and dark banding in fast spin‐echo acquisitions within a typical brain‐scan field of view. They can confound the prescan correction for eddy currents and degrade image quality. Performing real‐time compensation successfully eliminates the artifacts.ConclusionsWe demonstrate that the zeroth/first‐order CFs specific to asymmetric gradients can cause substantial artifacts, including signal loss and dark bands for brain imaging. These effects can be corrected using real‐time compensation. Magn Reson Med 79:1354–1364, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Ultra‐short echo time images quantify high liver iron
Authors: Doyle Eamon K. , Toy Kristin , Valdez Bertin , Chia Jonathan M. , Coates Thomas , Wood John C. 
Published: June 2017

Purpose1.5T gradient echo‐based
estimates are standard‐of‐care for assessing liver iron concentration (LIC). Despite growing popularity of 3T, echo time (TE) limitations prevent 3T liver iron quantitation in the upper half of the clinical range (LIC
20 mg/g). In this work, a 3D radial pulse sequence was assessed to double the dynamic range of 3T LIC estimates.Theory and MethodsThe minimum TE limits the dynamic range of pulse sequences to estimate
. 23 chronically‐transfused human volunteers were imaged with 1.5T Cartesian gradient echo (1.5T‐GRE), 3T Cartesian gradient echo (3T‐GRE), and 3T ultrashort TE radial (3T‐UTE) pulse sequences; minimum TEs were 0.96, 0.76, and 0.19 ms, respectively.
was estimated with an exponential signal model, normalized to 1.5T equivalents, and converted to LIC. Bland–Altman analysis compared 3T‐based estimates to 1.5T‐GRE.ResultsLIC by 3T‐GRE was unbiased versus 1.5T‐GRE for LIC
25 mg/g (sd = 9.6%); 3T‐GRE failed to quantify LIC > 25 mg/g. At high iron loads, 3T‐UTE was unbiased (sd = 14.5%) compared to 1.5T‐GRE. Further, 3T‐UTE estimated LIC up to 50 mg/g, exceeding 1.5T‐GRE limits.Conclusion3T‐UTE imaging can reliably estimate high liver iron burdens. In conjunction with 3T‐GRE, 3T‐UTE allows clinical LIC estimation across a wide range of liver iron loads. Magn Reson Med 79:1579–1585, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Eltrombopag use in a patient with Wiskott–Aldrich syndrome
Authors: Gabelli Maria , Marzollo Antonio , Notarangelo Lucia Dora , Basso Giuseppe , Putti Maria Caterina 
Published: June 2017

AbstractWiskott–Aldrich syndrome (WAS) is an inherited X‐linked disorder characterized by microthrombocytopenia, immunodeficiency, and eczema. Hematopoietic stem cell transplantation (HSCT) is the treatment of choice. Eltrombopag, a thrombopoietin receptor agonist, may be useful to prevent bleeding while awaiting HSCT. We present a case of a male with WAS, profound thrombocytopenia, and bleeding diathesis successfully managed with eltrombopag before HSCT. Eltrombopag was given for 32 weeks obtaining a stable platelet count without any platelet transfusion. The patient did not experience any bleeding symptom. Eltrombopag may be a suitable therapeutic option for patients with WAS and severe thrombocytopenia as “bridge” to definitive cure.
Towards the synthesis of poly(azafulleroid)s: main chain fullerene oligomers for organic photovoltaic devices
Authors: Bregadiolli Bruna A , Ramanitra Hasina H , Ferreira Rodrigo Marques , Corcoles Laura , Gomes Milton S , Kang Lauren , Combe Craig MS , Silva Hugo Santos , Lavarda Francisco C , Bégué Didier , Dagron‐Lartigau Christine , Rocco Maria Luiza M , Luscombe Christine K , Olivati Clarissa A , Graeff Carlos FO , Hiorns Roger C 
Published: June 2017

AbstractFor the first time, imino chemistry is explored for the synthesis of main chain fullerene oligomers and low‐molecular‐weight polymers. Oligo(aziridinofullerene)s and low‐molecular‐weight poly(aziridinofullerene)s (PAFs) are prepared by 1,3‐dipolar cycloadditions of bis(azidoalkyl) comonomers to C60. The effect of the steric bulk of the comonomer is studied and it is found that PAF solubilities and molecular weights are increased with longer comonomer side‐chains. Initial and promising photovoltaic characterizations show commensurate improvements in properties. Interestingly, the PAFs exhibit lowest unoccupied molecular orbitals close to those of phenyl‐C61‐butyric acid methyl ester. Routine characterizations are correlated with DFT/B3LYP/6‐31G(d) to understand structural and electronic behaviours. It is expected that higher molecular weights may be obtained through comonomer variations and that this novel methodology will open a route to interesting materials for optoelectronics. © 2017 Society of Chemical Industry
Exploring the latent structure of the Luria model for the KABC‐II at school age: Further insights from confirmatory factor analysis
Authors: McGill Ryan J. 
Published: June 2017

AbstractThe present study examined the factor structure of the Luria interpretive model for the Kaufman Assessment Battery for Children‐Second Edition (KABC‐II) with normative sample participants aged 7–18 (N = 2,025) using confirmatory factor analysis with maximum‐likelihood estimation. For the eight subtest Luria configuration, an alternative higher‐order model with Pattern Reasoning being permitted to cross‐load on the Planning and Simultaneous Processing factors provided the best fit to the normative sample data. Variance apportionment suggests that additional consideration, beyond the omnibus Mental Processing Index, of the contribution of the first‐order factor‐based scores (i.e., SQ, SM, P, and L), and in some cases the individual subtests themselves, may be warranted. Implications for clinical interpretation and the anticipated normative update of the measurement instrument are discussed.
The relationship among achievement goals, standardized test scores, and elementary students’ focus in school
Authors: Jones Martin H. , Mueller Christian E. 
Published: June 2017

AbstractThe study examined whether an academic, social, or both an academic and social focus might relate with achievement goals and academic achievement. Participants were 412 urban elementary school students. Results suggest that students with an academic focus toward school have more mastery‐approach and less mastery‐avoid achievement goals. Academic achievement (standardized test scores) did not relate with boys’ or girls’ focus toward school. These findings suggest that academic motivation, but not achievement, correspond with self‐perceptions of school as being a place to learn or school as a place for social interactions.
Phenotypic Analysis of Organoids by Proteomics
Authors: Gonneaud Alexis , Asselin Claude , Boudreau François , Boisvert François‐Michel 
Published: June 2017

AbstractThe development of 3D cell cultures into self‐organizing organ‐like structures named organoids provides a model that better reflects in vivo organ physiology and their functional properties. Organoids have been established from several organs, such as the intestine, prostate, brain, liver, kidney and pancreas. With recent advances in high‐throughput and ‐omics profiling technologies, it is now possible to study the mechanisms of cellular organisation at the systems level. It is therefore not surprising that these methods are now used to characterize organoids at the transcriptomic, proteomic, chromatin state and transcription factor DNA‐binding levels. These approaches can therefore provide a wealth of information regarding both the mechanisms involved in different diseases, and those involved in cell responses to different conditions, in a more in vivo setting. The authors provide an overview of the potential applications of quantitative mass spectrometry with organoid culture, and how the use of large‐scale proteome measurements is emerging in different organoid systems.
Random multiacceptor poly(2,7‐carbazole) derivatives containing the pentacyclic lactam acceptor unit TPTI for bulk heterojunction solar cells
Authors: Ekiz Seyma , Thompson Barry C. 
Published: June 2017

ABSTRACTHere, a family of donor/acceptor (D/A) alternating copolymers and random two‐acceptor and three‐acceptor copolymers were synthesized via Suzuki polymerization based on heptadecan‐9‐yl substituted carbazole as a donor and 4,7‐Bis(5‐bromothiophene‐2‐yl)benzo[c][1,2,5]thiadiazole (DTBT), 2,5‐diethylhexyl‐3,6‐bis(5‐bromothiophene‐2‐yl)pyrrolo[3,4‐c]‐pyrrole‐1,4‐dione (DPP) and 2,8‐dibromo‐4,10‐bis(2‐ethylhexyl)thieno[2′,3′:5,6] pyrido[3,4‐g]thieno[3,2‐c]isoquinoline‐5,11(4H,10H)‐dione (TPTI) as acceptors. For the first time, a relatively new electron‐deficient TPTI unit was used as an acceptor in carbazole‐based conjugated polymers. Introduction of the electron‐deficient TPTI unit into the polymer backbone increased the open‐circuit voltage (Voc) of the resulting polymer solar cells up to 0.96 V. PCTPTI and PCDTBT‐TPTI exhibited external quantum efficiencies (EQE) up to 75%. All random two‐acceptor copolymers showed broadened absorption profiles compared to the D/A alternating analogues. In order to further improve the light absorption, a random three‐acceptor copolymer was synthesized for the first time, resulting in the broadest absorption in the range of 350–750 nm. Highest occupied molecular orbital (HOMO) energies and Voc values of the resulting polymers could be successfully tuned by introducing different monomer units into the polymer backbone in different ratios. These results indicate that TPTI is a promising acceptor unit for conjugated polymers and that the random copolymer approach is a successful tool for fine tuning of polymer properties. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2781–2786
Cationic Cytosine Morpholino‐Based Transporters: Synthesis and Regulation of Intracellular Localization
Authors: Nandi Bappaditya , Khatra Harleen , Khan Pragya Paramita , Bhadra Jhuma , Pattanayak Sankha , Sinha Surajit 
Published: June 2017

AbstractCationic guanidinium and phosphonium functionalized cytosine morpholino tetramer (G3) and trimer (P3) have been reported for the first time. They show efficient cellular uptake properties in full growth medium, quantified by fluorescence activated cell sorting (FACS) and visualized by fluorescence microscopy. An interesting feature of these transporters is their localization in the nucleolus or the rest of nucleus, determined by the nature of cationic moieties attached with cytosine base. Co‐staining with MitoTracker Deep Red depicts their ability to penetrate mitochondrial membrane. Fluorescence imaging displays their uniform distribution throughout zebrafish larvae with no significant toxicity. FACS analysis at 4°C indicated that transfection of G3 transporter is energy dependent whereas P3 is energy independent. When covalently conjugated, G3 is capable of transporting a 25‐mer phosphorodiamidate morpholino oligomer (PMO) into the cells. It exhibits antisense effect against Gli1 gene in hedgehog pathway, confirmed in preliminary β‐glactosidase assay performed in Ptch1–/– cells. Further antisense effect was confirmed when G3‐conjugated zebrafish Gli1‐PMO was injected into embryo to obtain Gli1‐dependent phenotypes. To the best of our knowledge, herein, we first report that molecular transporters with a minimum number of three cationic groups are capable of efficiently passing through plasma, nuclear and mitochondrial membranes and show distribution in zebrafish larvae.
An Insight into a Fascinating DMF‐Water Mixed Solvent System: Physicochemical and Electrochemical Studies
Authors: Pandit Sarwar Ahmad , Rather Mudasir Ahmad , Bhat Sajad Ahmad , Jan Roohi , Rather Ghulam Mohd , Bhat Mohsin Ahmad 
Published: June 2017

AbstractA systematic study of electrical conductivity, density and viscosity over solutions of tetraethylammonium bromide(TEAB) and 1‐butyl‐3‐methylimidazolium methylsulfate ([BMIM][MeSO4]) in variedly composed dimethyl formamide (DMF) plus water mixtures was carried to explore the potential advantages of such mixed solvent systems for electrochemical investigations. The estimated transport and bulk characteristics of TEAB and [BMIM][MeSO4] in the mixed solvent revealed strong composition dependent interactions are present in the DMF‐Water mixed solvent systems. Such results intrigued us to study the impact of solution properties of DMF‐water systems on electrochemical behavior of redox probe para‐nitrotoluene (PNT).The estimated transport, kinetic and thermodynamic parameters were correlated with the estimated values for viscosity, density and calculated values of dielectric constant for the mixed solvent. The kinetics of PNT was found to be controlled by outer sphere solvent reorganization in DMF‐water solvent system for both the supporting electrolytes viz. TEAB and [BMIM][MeSO4], upto composition range of 0.35 mole fraction of DMF in water.
Prediction of severe pre‐eclampsia/HELLP syndrome by combination of sFlt‐1, CT‐pro‐ET‐1 and blood pressure: exploratory study
Authors: Lind Malte A. , Uldbjerg N. , Wright D. , Tørring N. 
Published: June 2017

ABSTRACTObjectivesTo evaluate the performance of a combination of angiogenic and vasoactive biomarkers to predict the development of severe pre‐eclampsia (PE)/HELLP syndrome in the third trimester.MethodsIncluded were 215 women referred in the third trimester to an obstetric outpatient clinic with suspected PE (mean gestational age, 35 + 4 weeks), and 94 with normal pregnancy attending a midwife clinic. Cases were categorized as having subclinical PE, essential hypertension, gestational hypertension, moderate PE, and severe PE/HELLP syndrome. Blood samples were analyzed by immunoassay and groups were compared with respect to potential clinical and biochemical biomarkers, with the primary outcome being development of severe PE/HELLP syndrome within 1 week and within 2 weeks of analysis. The most promising markers were also assessed in combination.ResultsIn the patients presenting with mild to moderate symptoms of PE, the individual markers which performed best for the prediction of progression to severe PE/HELLP syndrome within 1 week and within 2 weeks of biomarker evaluation were C‐terminal pro‐endothelin‐1 (CT‐pro‐ET‐1) (area under the receiver–operating characteristics curve (AUC), 0.82 and 0.78, respectively), soluble fms‐like tyrosine kinase‐1 (sFlt‐1) (AUC, 0.81 and 0.76), systolic blood pressure (AUC, 0.80 and 0.68) and midregional pro‐atrial natriuretic peptide (AUC, 0.79 and 0.77). The combination of biomarkers with the best performance was CT‐pro‐ET‐1, sFlt‐1 and systolic blood pressure, achieving an AUC of 0.94 for prediction of development of severe PE/HELLP syndrome within 1 week and an AUC of 0.83 for prediction of their development within 2 weeks of biomarker evaluation.ConclusionsThe performance of CT‐pro‐ET‐1 for prediction of the development of PE/HELLP syndrome in the third trimester was promising, especially in combination with sFlt‐1 and systolic blood pressure. This was an exploratory study and our findings should be confirmed in further studies. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Cover Image, Volume 6, Issue 4
Authors: Tao Hirotaka , Kawakami Yasuhiko , Hui Chi‐chung , Hopyan Sevan 
Published: June 2017

The cover image, by Hirotaka Tao et al., is based on the Advanced Review The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies, DOI: 10.1002/wdev.270.
image
Post-diagnosis serum insulin-like growth factors in relation to dietary and lifestyle changes in the Prostate testing for cancer and Treatment (ProtecT) trial
Authors: Er Vanessa , Biernacka Kalina , Simpkin Andrew J. , Martin Richard M. , Jeffreys Mona , Emmett Pauline , Gilbert Rebecca , Avery Kerry N. L. , Walsh Eleanor , Davis Michael , Donovan Jenny L. , Neal David E. , Hamdy Freddie C. , Holly Jeff M. P. , Lane J. Athene 
Published: June 2017

AbstractPurposeThe insulin-like growth factor (IGF) system is modifiable by diet and lifestyle, and has been linked to prostate cancer development and progression.MethodsWe conducted a prospective cohort study of 621 men diagnosed with localized prostate cancer to investigate the associations of dietary and lifestyle changes with post-diagnosis circulating levels of IGF-I and IGFBP-3. We used analysis of covariance to estimate the associations, controlling for baseline IGF-I or IGFBP-3, respectively.ResultsMean IGF-I levels were 6.5% (95% CI −12.8, −0.3%,p = 0.04) lower in men who decreased their protein intake after diagnosis compared to men who did not change. Men who changed their fruit and vegetable intake had lower IGF-I levels compared to non-changers [Decreased intake: −10.1%, 95% CI −18.4, −1.8%,p = 0.02; Increased intake: −12.0%, 95% CI −18.4, −1.8%,p = 0.002]. IGFBP-3 was 14.6% (95% CI −24.5, −4.8%,p = 0.004) lower in men who achieved a healthy body mass index after diagnosis. Men who became inactive had 9.5% higher average IGF-I levels (95% CI 0.1, 18.9%,p = 0.05).ConclusionsDecreased protein intake and body mass index, and increased physical activity and fruit and vegetable intake, following a prostate cancer diagnosis were associated with reduced post-diagnosis serum IGF-I and IGFBP-3. Counterintuitively, reduced fruit and vegetable intake was also associated with reduced IGF-I, but with weak statistical support, possibly implicating chance. If confirmed in other studies, our findings may inform potential lifestyle interventions in prostate cancer. ProtecT was registered at International Standard Randomised Controlled Trial Registry,http://isrctn.orgas ISRCTN20141297.