bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plataforma para el registro de nefrolitotomía percutánea interinstitucional
Authors: Solano Mendoza Catalina , Ortiz Alfredo , Serrano Adolfo , Rueda Raúl , Tarazona Nick 
Published: July 2017

Introducción Las opciones para el tratamiento de cálculos renales son: la litotripcia extracorpórea, la ureterorrenoscopia flexible y la nefrolitotomía percutánea (NLP). Se ha visto que a pesar del advenimiento de nuevas tecnologías y técnicas quirúrgicas, la NLP sigue presentando una importante tasa de complicaciones, por lo que es necesario la estandarización de la técnica y la escogencia adecuada de los pacientes.
Metodología Se realizó una búsqueda de la literatura en Pubmed sin límite de fecha en la que se tuviera en cuenta palabras claves como: registro de NLP, sistemas de puntuación en NLP, características preoperatorias tenidas en cuenta en NLP. Posteriormente se socializaron dichas variables con expertos en el tema, creando una plataforma que permitiera el registro de los pacientes a quienes se les realizó NLP en el país.
Resultados Se desarrolló una plataforma web para el registro a través de dispositivos móviles, tabletas, celulares, etc. de todos los pacientes a quienes se les realizó NLP en instituciones como: FOSCAL, Fundación Santa Fé de Bogotá y Clínica Chicamocha. Una vez ingresado los datos, estos se enviaron automáticamente a una base de datos consignados en una hoja tipo Excel. Por último se creó una red de especialistas para la participación virtual por medio de la misma.
Conclusiones El registro nacional de NLP es un estudio en tiempo real y de fácil acceso que permite obtener datos relevantes de los pacientes a quienes se les realiza NLP en varias instituciones del país. Adicionalmente proporcionará bases para la creación de estudios multicéntricos y publicaciones de literatura colombiana.
Description and validation of a new automated surveillance system for Clostridium difficile in Denmark
Authors: CHAINE M. , GUBBELS S. , VOLDSTEDLUND M. , KRISTENSEN B. , NIELSEN J. , ANDERSEN L. P. , ELLERMANN-ERIKSEN S. , ENGBERG J. , HOLM A. , OLESEN B. , SCHØNHEYDER H.C. , ØSTERGAARD C. , ETHELBERG S. , MØLBAK K. 
Published: July 2017

SUMMARYThe surveillance of Clostridium difficile (CD) in Denmark consists of laboratory based data from Departments of Clinical Microbiology (DCMs) sent to the National Registry of Enteric Pathogens (NREP). We validated a new surveillance system for CD based on the Danish Microbiology Database (MiBa). MiBa automatically collects microbiological test results from all Danish DCMs. We built an algorithm to identify positive test results for CD recorded in MiBa. A CD case was defined as a person with a positive culture for CD or PCR detection of toxin A and/or B and/or binary toxin. We compared CD cases identified through the MiBa-based surveillance with those reported to NREP and locally in five DCMs representing different Danish regions. During 2010–2014, NREP reported 13 896 CD cases, and the MiBa-based surveillance 21 252 CD cases. There was a 99·9% concordance between the local datasets and the MiBa-based surveillance. Surveillance based on MiBa was superior to the current surveillance system, and the findings show that the number of CD cases in Denmark hitherto has been under-reported. There were only minor differences between local data and the MiBa-based surveillance, showing the completeness and validity of CD data in MiBa. This nationwide electronic system can greatly strengthen surveillance and research in various applications.
Estimating the Location of World Wheat Price Discovery
Authors: Janzen Joseph P. , Adjemian Michael K. 
Published: July 2017

AbstractThe United States may be losing its leadership role in the world wheat market. Rising trading volume in foreign futures markets and shifting shares of world trade are suggested as evidence of this shift, but neither necessitates that futures markets in the United States are any less important for wheat price discovery. This paper applies high frequency pricing data and market microstructure methods, including the Yan and Zivot (2010) information leadership share, to estimate the proportion of price discovery occurring in wheat futures markets associated with Chicago, Kansas City, Minneapolis, and Paris. We find United States futures markets remain dominant, although the share of price discovery for the Paris market increased noticeably in 2010, coinciding with major supply shocks in Russia and Ukraine. Prior to August 2010, 91% of information about the common fundamental value of wheat was first revealed in United States futures markets in an average month. After August 2010, this share dropped to 75%.
Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality
Authors: Rastall David P W , Alyaquob Fadel S , O’Connell Patrick , Pepelyayeva Yuliya , Peters Douglas , Godbehere-Roosa Sarah , Pereira-Hicks Cristiane , Aldhamen Yasser A , Amalfitano Andrea 
Published: July 2017

Abstract
Specific variants of endoplasmic reticulum-associated aminopeptidase 1 (ERAP1) identified by genome-wide association study modify the risk for developing ankylosing spondylitis. We previously confirmed that disease-associated ERAP1 variants have altered enzymatic abilities that can impact upon the production of pro-inflammatory cytokines from cells expressing the same ERAP1 variants. To determine if these ERAP1 variants also impacted immune responses in vivo, we generated two strains of transgenic mice expressing human ERAP1 genes containing non-synonymous single-nucleotide polymorphisms associated with an increased (ERAP1-High) or decreased (ERAP1-Low) risk for developing autoimmune disease. After vaccination with foreign antigens, ERAP1-High mice generated unique populations of antigen-specific T-cell clones. The expression of ERAP1-High also reduced MHC-I expression on the surface of multiple cell types, demonstrating a global impact on the MHC-I peptidome. ERAP1 variants also affected the innate immune system, because NK cells from murine ERAP1 (mERAP1) knockout mice and ERAP1-High/mERAP1−/− mice had decreased surface expression of the activating receptor NKG2D on their NK and T cells, and NK cells derived from mERAP1−/− mice or ERAP1-Low mice demonstrated more active NK cell killing than NK cells derived from wild-type or ERAP1-High mice. Finally, these studies were conducted in female mice, as all male ERAP1-High mice died in utero or shortly after birth, making ERAP1-High one of the only dominant lethal autosomal genes known in mammals. Together, these results present the first direct evidence that human disease-associated ERAP1 variants can greatly alter survival, as well as antigen presentation, T-cell repertoire and NK cell responses in vivo.
Fracture after radiation therapy for femoral metastasis: incidence, timing and clinical features
Authors: Shimoyama Tetsuo , Katagiri Hirohisa , Harada Hideyuki , Murata Hideki , Wasa Junji , Hosaka Seiichi , Suzuki Takayoshi , Takahashi Mitsuru , Asakura Hirofumi , Nishimura Tetsuo , Yamada Harumoto 
Published: July 2017

ABSTRACTWe analyzed 428 femoral metastases initially treated with radiotherapy between 2002 and 2011 to clarify the clinical details of post-irradiation fractures of femoral metastasis. Patients included 161 men and 167 women, with a mean age of 62 years. Fracture incidence, fracture site, fracture risk based on X-ray images before radiotherapy, and interval from completion of radiotherapy to fracture occurrence were assessed. In addition, 24 pathological specimens obtained during 27 surgeries for these fractures were examined. Fractures occurred in 7.7% of 428 femoral metastases (total 33: 28 actual fractures and five virtual fractures with progressive pain and bone destruction). The fracture rate was 7.8% in the proximal femur and 1.5% in the shaft (P = 0.001). Fractures occurred a median of 4.4 months after radiotherapy, with 39.4% occurring within 3 months and 63.6% within 6 months. Among femurs with high fracture risk according to Harrington’s criteria or Mirels’ score, the fracture rate was 13.9% and 11.8%, respectively. Viable tumor cells were detected in all five patients with painful virtual fracture, in 85.7% of femurs with actual fractures that occurred within 3 months, and in only 25.0% of actual fractures occurring after 3 months. Post-irradiation fractures of femoral metastasis most frequently occurred within 3 months after radiotherapy, and were more common in the peritrochanteric area than in the shaft. Radiological evidence of impending fracture did not correlate with a high fracture rate. Actual fractures occurring after more than 3 months were likely caused by post-irradiation fragility of the femur, without viable tumor cells.
Suction Energy for Double-Stranded DNA Inside Single-Walled Carbon Nanotubes
Authors: Alshehri Mansoor H , Hill James M 
Published: July 2017

Summary
Deoxyribonucleic acid (DNA) and carbon nanotubes (CNTs) constitute hybrid materials with the potential to provide new components with many applications in various technology areas, such as molecular electronics, field devices and medical applications. Using classical applied mathematical modelling, we investigate the suction force experienced by a double-stranded DNA (dsDNA) molecule which is assumed to be located on the axis near an open end of a semi-infinite single-walled CNT. We employ both the 6-12 Lennard-Jones potential and the continuum approximation, which assumes that a discrete atomic structure can be replaced by a surface with constant average atomic density. While most research in the area is dominated by molecular dynamics simulations, here we use elementary mechanical principles and classical applied mathematical modelling techniques to formulate explicit analytical criteria and ideal model behaviour. We observe that the suction behaviour depends on the radius of the CNT, and we predict that it is less likely for a dsDNA molecule to be accepted into the CNT when the value of the tube radius is ${<}12.9$ Å. The dsDNA molecule will be accepted into the CNT for radii lager than 13 Å, and we show that the optimal single-walled CNT necessary to fully enclose the DNA molecule has a radius of 13.56 Å, which approximately corresponds to the chiral vector numbers (20, 20). This means that the ideal single-walled CNT to be used to encapsulate a dsDNA is (20, 20) which has the required radius of 13.56 Å.
Turning 1 Year of Age in a Low Socioeconomic Environment: A Portrait of Disadvantage
Authors: Hurt Hallam , Betancourt Laura M. 
Published: July 2017

ABSTRACT:
In the United States today, 16 million children are growing up poor. Few studies report multiple environmental factors associated with poverty during the first year of life and effects on infant development.

Objectives:
To evaluate maternal, home, and neighborhood environment of low and higher socioeconomic status (SES) infants from birth to 1 year and to evaluate the impact of SES and environment on infant developmental outcome at 1 year.

Methods:
Low (n = 30) and higher SES (n = 30) African-American mothers and their healthy term gestation female infants were prospectively compared for environmental characteristics and infant developmental outcome. Wechsler Adult Intelligence Scale-IV (WAIS-IV); Beck Depression Inventory; Perceived Stress Scale; Parenting Stress Index-Fourth Edition (PSI-4); Social Support Scale; Home Observation Measurement of the Environment (HOME); Household Food Insecurity (HFI); Concentrated Neighborhood Disadvantage (CND). Bayley Scales of Infant Development Third Edition (BSID-III); Preschool Language Scale (PLS-5).

Results:
Environmental risk was greater for low compared with higher SES: lower WAIS-IV (p < .001); higher PSI-4 total (p = .003); lower HOME total and 3 subscales (p < .002); higher HFI (p = .012); and higher CND (p = .027). Low SES infant outcomes differed from higher SES: lower BSID-III Cognitive Composite (p = .005), PLS-5 Total Language (p ≤ .017), and Auditory Comprehension (p ≤ .008). In regressions, after controlling for SES, effects of environmental factors were not found.

Conclusion:
By age 1, low SES infants had been exposed to greater environmental disadvantage and already exhibited poorer developmental functioning than higher SES infants. These findings suggest that support for families and children from impoverished circumstances cannot begin too early.
ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY VERSUS PHOTODYNAMIC THERAPY IN THE TREATMENT OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO CENTRAL SEROUS CHORIORETINOPATHY
Authors: Peiretti Enrico , Caminiti Giulia , Serra Rita , Querques Lea , Pertile Riccardo , Querques Giuseppe 
Published: July 2017

Purpose:
To evaluate the efficacy of photodynamic therapy (PDT) compared with intravitreal vascular endothelial growth factor (VEGF) inhibitors alone or combined with PDT in the treatment of choroidal neovascularization (CNV) secondary to chronic central serous chorioretinopathy (CSCR).

Methods:
Retrospective study of a consecutive series of 34 white patients (34 eyes) with angiographic evidence of choroidal neovascularization secondary to chronic central serous chorioretinopathy, divided into two groups followed for at least 12 months: 16 were treated with full fluence PDT (PDT group) and 18 with vascular endothelial growth factor inhibitors (intravitreal [IVT] group).

Results:
In the PDT group, mean best-corrected visual acuity (BCVA) was 20/40 (0.30 ± 0.69 logMAR) at baseline and did not change after 12 months (20/40; 0.30 ± 0.49 logMAR [P = 0.49]). In the IVT group mean, best-corrected visual acuity was 20/40 (0.30 ± 0.69 logMAR) at baseline and also did not change at the 12-month follow-up (20/32; 0.20 ± 0.49 logMAR [P = 0.20]). There was no statistically significant difference between the two groups in terms of best-corrected visual acuity. A statistical significance difference was found in central macular thickness between the two groups with a better reduction of the thickening in the PDT group (P = 0.05); moreover, indocyanine green angiography analysis revealed that 50% of the polypoidal lesions were closed after PDT and 25% of the polypoidal lesions disappeared after anti–vascular endothelial growth factor therapy at 12-month follow-up.

Conclusion:
PDT and IVT inhibitors alone or combined show similar clinical effects in chronic central serous chorioretinopathy eyes with choroidal neovascularization.
Pancreatic Duct in Autoimmune Pancreatitis
Authors: Kim Jin Hee , Byun Jae Ho , Kim Myung-Hwan , Lee Sung Koo , Kim Song Cheol , Kim Hyoung Jung , Lee Seung Soo , Kim So Yeon , Lee Moon-Gyu 
Published: July 2017

Objective
The aim of this study was to intraindividually compare magnetic resonance pancreatography (MRP) image quality at 1.5 T and 3.0 T when demonstrating main pancreatic duct (MPD) abnormalities in patients with autoimmune pancreatitis (AIP).

Methods
Thirty prospectively enrolled patients with AIP underwent MRP at both 1.5 T and 3.0 T followed by endoscopic retrograde pancreatography before treatment. Two readers independently analyzed the MRP images and graded the visualization of MPD strictures and full-length MPD, using endoscopic retrograde pancreatography as the reference standard, as well as overall image artifacts on a 4-point scale. The contrast between the MPD and periductal area was calculated using a region-of-interest measurement.

Results
Visualization scores of MPD strictures and full-length MPD, and summed scores of each qualitative analysis, were significantly greater at 3.0-T MRP than at 1.5-T MRP for both readers (P ≤ 0.02). There were less image artifacts at 3.0 T compared with 1.5 T (P ≤ 0.052). The contrast between the MPD and periductal area was significantly greater at 3.0-T MRP than at 1.5-T MRP (P < 0.001).

Conclusions
The MRP at 3.0 T was superior to 1.5-T MRP for demonstrating MPD abnormalities in AIP, with better image contrast and fewer image artifacts. Consequently, 3.0-T MRP may be useful for the diagnosis and management of patients with AIP.
Describing Peripancreatic Collections According to the Revised Atlanta Classification of Acute Pancreatitis
Authors: Bouwense Stefan A. , van Brunschot Sandra , van Santvoort Hjalmar C. , Besselink Marc G. , Bollen Thomas L. , Bakker Olaf J. , Banks Peter A. , Boermeester Marja A. , Cappendijk Vincent C. , Carter Ross , Charnley Richard , van Eijck Casper H. , Freeny Patrick C. , Hermans John J. , Hough David M. , Johnson Colin D. , Laméris Johan S. , Lerch Markus M. , Mayerle Julia , Mortele Koenraad J. , Sarr Michael G. , Stedman Brian , Vege Santhi Swaroop , Werner Jens , Dijkgraaf Marcel G. , Gooszen Hein G. , Horvath Karen D. 
Published: July 2017

Objectives
Severe acute pancreatitis is associated with peripancreatic morphologic changes as seen on imaging. Uniform communication regarding these morphologic findings is crucial for accurate diagnosis and treatment. For the original 1992 Atlanta classification, interobserver agreement is poor. We hypothesized that for the revised Atlanta classification, interobserver agreement will be better.

Methods
An international, interobserver agreement study was performed among expert and nonexpert radiologists (n = 14), surgeons (n = 15), and gastroenterologists (n = 8). Representative computed tomographies of all stages of acute pancreatitis were selected from 55 patients and were assessed according to the revised Atlanta classification. The interobserver agreement was calculated among all reviewers and subgroups, that is, expert and nonexpert reviewers; interobserver agreement was defined as poor (≤0.20), fair (0.21–0.40), moderate (0.41–0.60), good (0.61–0.80), or very good (0.81–1.00).

Results
Interobserver agreement among all reviewers was good (0.75 [standard deviation, 0.21]) for describing the type of acute pancreatitis and good (0.62 [standard deviation, 0.19]) for the type of peripancreatic collection. Expert radiologists showed the best and nonexpert clinicians the lowest interobserver agreement.

Conclusions
Interobserver agreement was good for the revised Atlanta classification, supporting the importance for widespread adaption of this revised classification for clinical and research communications.
Overexpression of Yes Associated Protein 1, an Independent Prognostic Marker in Patients With Pancreatic Ductal Adenocarcinoma, Correlated With Liver Metastasis and Poor Prognosis
Authors: Salcedo Allende Maria Teresa , Zeron-Medina Jorge , Hernandez Javier , Macarulla Teresa , Balsells Joaquim , Merino Xavier , Allende Helena , Tabernero Josep , Ramon y Cajal Agüeras Santiago 
Published: July 2017

Objectives
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer. Overexpression of Yes associated protein 1 (YAP1), a downstream target of Hippo pathway, implicated in regulation of cell growth and apoptosis, has been reported in several human tumor types. The objective of this study was to investigate YAP1 expression in patients with PDAC and its prognostic values.

Methods
We evaluated YAP1 expression in 64 PDAC and 15 chronic pancreatitis (CP) cases and its related pancreatic intraepithelial neoplasia (PanIN) lesions and in 5 control subjects. Yes associated protein 1 expression was determined by immunohistochemistry. Association of YAP1 with clinicopathologic features in PDAC, disease-free survival, and overall survival was analyzed.

Results
We found a higher positive rate of nuclear expression of YAP1 in PDAC than in CP (P = 0.000) and lower expression of YAP1 in PanIN lesions in CP in contrast with expression in PanIN lesions in PDAC. Nuclear overexpression of YAP1 in PDAC is associated with hepatic metastasis (P = 0.0280) and is a prognostic factor (P = 0.0320), as well as surgical margin involvement (P = 0.0013) and tumoral stage (P = 0.0109).

Conclusions
Overexpression of YAP1 may occur as a part of tumorigenesis of PDAC. Yes associated protein 1 is an independent prognostic marker for overall survival of PDAC and associated with liver metastasis, being a potential therapeutic target.
Cavitary Choroidal Metastasis from Clear Cell Renal Cell Carcinoma
Authors: Ayres Bernadete , McClendon Tanya , Demirci Hakan 
Published: July 2017

PURPOSE
To report the clinical, funduscopic, and echographic features of a choroidal metastatic tumor from a clear cell renal cell carcinoma presenting with intralesional cavitation.

CASE REPORT
An 81-year-old man with history of clear cell renal cell carcinoma presented with blurred vision. A clinical examination including standardized ultrasound was performed, which revealed a choroidal mass with cystic-like cavitation. The patient underwent brachytherapy with regression of the tumor.

CONCLUSIONS
We report the features of a cavitary choroidal metastasis from clear cell renal cell carcinoma. Occurrence of features usually associated with uveal melanoma in a patient with a metastatic choroidal tumor may lead to misdiagnosis.
Diagnosis of Vitality in Skin Wounds in the Ligature Marks Resulting From Suicide Hanging
Authors: Legaz Pérez Isabel , Falcón Maria , Gimenez M. , Diaz F. Martínez , Pérez-Cárceles M.D. , Osuna E. , Nuno-Vieira D. , Luna A. 
Published: July 2017

Abstract
Ascertaining the vital origin of skin wounds is one of the most challenging problems in forensic pathology. The forensic literature describes biomarkers and methods for differentiating vital and postmortem wounds, although no clear conclusions have been reached. The aim of this study was to characterize human vital wounds by analyzing the concentrations of metallic ions and the expression of P-selectin and cathepsin D in skin wounds in the ligature marks in a cohort of suicidal hangings for which vitality was previously demonstrated.
A total of 71 skin wounds were analyzed within a postmortem interval of 19 to 36 hours. The concentration of Fe, Zn, Mg, and Ca and the expression of P-selectin and cathepsin D were analyzed together and separately. The majority of autopsied suicidal hangings were men (86%) with complete hanging mode (60.7%) in which there was a high frequency of subcutaneous injuries (78.3%). High concentrations of Ca and Mg compared with Fe and Zn were found. Ca and Zn concentrations decreased, and Fe concentration increased with the seriousness of the injury. A high percentage of moderately negative expression of both proteins was correlated with subcutaneous injury and low or medium concentrations of Fe.
In conclusion, the joint study of metallic ions and proteins allows to characterize and to differentiate an injured vital wound of noninjured skin, especially when the damage in the tissue affects to the majority of the structures of the skin, but these results will need to be complemented with other biomarkers in time-controlled samples to further help in the differentiation of vital and postmortem wounds.