bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling beta diversity of aquatic macroinvertebrates in High Andean wetlands
Authors: Nieto Carolina , Dos Santos Daniel A. , Izquierdo Andrea E. , Rodríguez José S. , Grau Héctor R. 
Published: July 2017

<p>Central Andean Highlands represent a singular environment characterized by various extreme conditions. Among them, peatbogs are exceptional marshy habitats scattered throughout this arid and harsh area. In an effort to understand the patterns of beta diversity, we sampled the benthic macroinvertebrates of thirteen peatbogs and related the biological distance with ecological distance using the GDM (Generalized Dissimilarity Modelling) approach. Variables analyzed were altitude, geographical distance, physical and chemical parameters of the water. A coefficient based on the ordering properties of count data, from the perspective of both sites and taxa, was used to measure the compositional similarity between samples. The most frequent taxa were: <em>Hyallela</em>, Simuliidae, <em>Andesiops</em>, <em>Austrelmis</em>, Podonominae, <em>Protallagma</em>, <em>Trichocorixa</em>, Orthocladiinae and Glossiphonidae. The highest altitudinal record ever for leeches is reported here. Altitude and conductivity contributed greatly to the single ecological predictor of beta diversity. Sampling points can be classified first by altitude (cutoff sets at 4,200 m), which can be considered a surrogate of a regional factor (distinction between Puna and High Andean ecoregions) and then by conductivity (cutoff sets at 135 µS cm<sup>-1</sup>), which can be considered a proxy of a local factor (distinction between hyperfresh and more mineralized habitats). These results suggest a system of ecological filters acting on them. </p>
Sentinel node biopsy in vulvar cancer: A critical appraisal
Authors: Hacker Neville , Barlow Ellen 
Published: July 2017

AbstractSince the incorporation of inguinal-femoral lymphadenectomy into the management of patients with vulvar cancer in the mid-20th century, there have been attempts to modify or eliminate the groin dissection to decrease the risk of lower limb lymphedema. Early attempts were significantly flawed and resulted in much unnecessary loss of life because recurrence in an undissected groin is usually fatal. The best compromise yet to decrease the risk of lymphedema is sentinel node biopsy, but accumulated evidence now suggests that the false-negative rate for this procedure, if used for lesions up to 4 cm in diameter, is between 5% and 10%. Most women, properly informed of risks and benefits, are not prepared to take a 1% risk of dying from recurrent vulvar cancer to avoid lymphedema. This is the risk involved, assuming a false-negative rate of 5% and an incidence of positive nodes of 20%. For this reason, sentinel node biopsy should not be considered to be standard practice for patients with early vulvar cancer.
Role of squamous cell carcinoma antigen in monitoring of treatment response of cervical and vaginal malignancies
Authors: Sachan Rekha , Patel Munna Lal , Singh Meenakshi , Sachan Pushpalata , Shyam Radhey 
Published: July 2017

Introduction: As per GLOBOCAN 2012 report Worldwide fourth most common cancer in the female is cervical cancer and approximately 528,000 new cases was found in 2012 in large majority of global burden was found in less developed country. India, the second most populous country in the world, accounts for 27% of the total cervical cancer deaths. The aim of this study was to assess the efficacy of squamous cells carcinoma antigen (SCC-Ag) in monitoring of response to treatment in cervical and vaginal cancer patients.
Materials and Methods: This prospective case–control study was carried out over a period of 1 year in the Department of Obstetrics and Gynecology in collaboration with the Department of Internal Medicine and Pathology. Histopathologically confirmed study group included 8 cases of Stage I, 15 cases of Stage II, 15 cases of Stage III, 8 cases of Stage IV cervical malignancy, and 5 cases of vaginal carcinoma. About 15 healthy cervical cytology-negative women were taken as controls.
Results: Out of 51 cancer cases SCC-Ag level were determined in only Stage I, II, III, and IV cases, assess the response to treatment. The mean SCC-Ag level in all four stage groups decreased significantly after post treatment as compared to pre treatment (P < 0.001) and the decrease in post treatment SCC-Ag level increased linearly with stage severity. Similarly, comparing the total or overall (Stage I + Stage II + Stage III) mean change (pre-post) in SCC-Ag level, t-test further revealed significant (P < 0.001) and decrease of 66.2% at posttreatment as compared to pretreatment.
Conclusion: SCC-Ag might be a useful marker in monitoring the response to treatment.
Weekly versus biweekly high-dose rate brachytherapy schedules in carcinoma cervix following concomitant chemoradiation with paclitaxel and carboplatin
Authors: Gogia Pooja , Dhull Anil , Kaushal Vivek 
Published: July 2017

Abstract
Context: In the management of cervical cancer, though a number of chemotherapeutic drugs have been used for concomitant chemoradiation, paclitaxel and carboplatin have shown improved overall response rates with acceptable side effects. The use of intracavitary irradiation significantly improves survival and reduces local failures. However, the ideal time-dose-fraction schedule remains controversial with high-dose rate (HDR) brachytherapy.
Aims: The aim of this study was to determine the efficacy and safety of paclitaxel and carboplatin for concomitant chemoradiation therapy and to compare the local control, toxicity, and tolerability of the two HDR brachytherapy schedules in patients of carcinoma cervix.
Subjects and Methods: The patients were divided randomly into two groups of thirty patients each. Both the groups were treated with a combination of external beam radiotherapy with 50 Gy/5 weeks/25 fractions to whole pelvis along with concomitant chemotherapy. The concomitant chemotherapy schedule was injection paclitaxel (135 mg/m2) and injection carboplatin (area under the curve - 4.5 mg min/ml) at 4-week interval followed by HDR brachytherapy. Following which, patients received HDR-intracranial brachytherapy on the basis of random allocation, Group I: 6 Gy × 3 fractions (weekly) and Group II: 5 Gy × 4 fractions (biweekly).
Results and Conclusion: The survival difference between the two groups (weekly and biweekly) was not statistically significant. However, Grade 2–3 rectal reactions in Group I were significantly higher than Group II (P = 0.038). The twice-weekly schedule of brachytherapy was a significant factor influencing the late complication rate but not the local pelvic control rate or overall survival rate.
A New Proof of the Hansen—Mullen Irreducibility Conjecture
Authors: Tuxanidy Aleksandr , Wang Qiang 
Published: July 2017

AbstractWe give a new proof of the Hansen–Mullen irreducibility conjecture. The proof relies on an application of a (seemingly new) sufficient condition for the existence of elements of degree n in the support of functions on finite fields. This connection to irreducible polynomials is made via the least period of the discrete Fourier transform (DFT) of functions with values in finite fields. We exploit this relation and prove, in an elementary fashion, that a relevant function related to the DFT of characteristic elementary symmetric functions (that produce the coefficients of characteristic polynomials) satisfies a simple requirement on the least period. This bears a sharp contrast to previous techniques employed in the literature to tackle the existence of irreducible polynomials with prescribed coefficients.
Assessing glacier melt contribution to streamflow at Universidad Glacier, central Andes of Chile
Authors: Bravo Claudio , Loriaux Thomas , Rivera Andrés , Brock Ben W. 
Published: July 2017

Abstract. Glacier melt is an important source of water for high Andean rivers in central Chile, especially in dry years, when it can be an important contributor to flows during late summer and autumn. However, few studies have quantified glacier melt contribution to streamflow in this region. To address this shortcoming, we present an analysis of meteorological conditions and ablation for Universidad Glacier, one of the largest valley glaciers in the central Andes of Chile at the head of the Tinguiririca River, for the 2009–2010 ablation season. We used meteorological measurements from two automatic weather stations installed on the glacier to drive a distributed temperature-index and runoff routing model. The temperature-index model was calibrated at the lower weather station site and showed good agreement with melt estimates from an ablation stake and sonic ranger, and with a physically based energy balance model. Total modelled glacier melt is compared with river flow measurements at three sites located between 0.5 and 50 km downstream. Universidad Glacier shows extremely high melt rates over the ablation season which may exceed 10 m water equivalent in the lower ablation area, representing between 10 and 13 % of the mean monthly streamflow at the outlet of the Tinguiririca River Basin between December 2009 and March 2010. This contribution rises to a monthly maximum of almost 20 % in March 2010, demonstrating the importance of glacier runoff to streamflow, particularly in dry years such as 2009–2010. The temperature-index approach benefits from the availability of on-glacier meteorological data, enabling the calculation of the local hourly variable lapse rate, and is suited to high melt regimes, but would not be easily applicable to glaciers further north in Chile where sublimation is more significant.
Unusual clinical picture in an overweight patient with Legionella pneumophila: A case report
Authors: Grigorakos Leonidas , Lazarescu Daria , Georgiadou Anthi , Bikou Maria , Gkouni Magda , Lafazanos Yorgos , Roumbeas Charalambos , Markou Nikolaos 
Published: July 2017

This case report describes a case of a patient with Legionnaires’ disease (LD) manifested three days upon his return from a medical conference, which took place in a hotel close to the seaside. Our patient presented to the hospital febrile, weak, confused and with mild difficulty in breathing. After being subjected to several tests, he was diagnosed with LD. Even though his initial urinary antigen test (UAT) was negative, subsequent immunofluorescent assays (IFA) were positive for Legionella pneumophila (LP). The patient was immediately initiated specific antibiotics therapy and supportive measures. After 11 days he was released from the hospital with considerable melioration of his clinical condition and with specific instructions to continue therapy at home.
A percepção dos professores do Curso de Administração de uma Universidade Federal do Nordeste sobre o processo seletivo para docentes
Authors: Almeida Neto Francisco Sergio de , Siqueira Elisabete Stradiotto , Binotto Erlaine 
Published: July 2017

This paper has aimed to analyze the perception of the administration course professors of a federal university at northeast that take part of selection processes have about the selection process which involved as applicants. The study consisted of exploratory research with qualitative complemented by quantitative data. This university is part of the REUNI program was chosen as analysis considering the expansion process that have been occurring on the last years. Took part in this survey 88% of the professors from administration course of the university. The data show that although in the university, teaching, research and extension compose the tripod that supports the academic making, this can not be perceived in the conceiving of the professors surveyed as an important value in the selection process. It is concluded that the board of assessment is the main target of criticism of the candidates. It needs more transparency, from the choice of the board to their evaluation criteria.This paper has aimed to analyze the perception of the administration course professors of a federal university at northeast that take part of selection processes have about the selection process which involved as applicants. The study consisted of exploratory research with qualitative complemented by quantitative data. This university is part of the REUNI program was chosen as analysis considering the expansion process that have been occurring on the last years. Took part in this survey 88% of the professors from administration course of the university. The data show that although in the university, teaching, research and extension compose the tripod that supports the academic making, this can not be perceived in the conceiving of the professors surveyed as an important value in the selection process. It is concluded that the board of assessment is the main target of criticism of the candidates. It needs more transparency, from the choice of the board to their evaluation criteria.
BACILLUS THURINGIENSIS VAR. ISRAELENSIS COMO ALTERNATIVA PARA O CONTROLE POPULACIONAL DE AEDES AEGYPTI (LINNAEUS, 1762) (DIPTERA: CULICIDAE)
Authors: Lutinski Junir Antonio , Kuczmainski Adriana Gracietti , De Quadros Suiane Oliveira , Busato Maria Assunta , Mohr Weirich Cleidenara Maria , Malgueiro Anderson , Mello Garcia Flávio Roberto 
Published: July 2017

Dengue, chikungunya and zika are among the major problems to public health problem in the world. In the absence of vaccine, the only known alternative to prevention is to control the mosquito. Among the methods of control, using biological strains of Bacillus thuringiensis israelensis (Bti) has stood out for its efficiency and security in the application. This study aimed to evaluate the efficiency of Bti to control the population of the Aedes aegypti mosquito in junkyards and recycling centers of Chapecó, Santa Catarina. Seven applications of Bti were conducted once every 21 days, three junkyards and three recycling centers, from August to December 2014. Was used wettable powder, soluble in water and applied at a concentration of 800 grams per hectare according to the manufacturer's technical specifications. The monthly number of larvae and of eggs and larvae of A. aegypti were recorded and compared with the results obtained in junkyards and recycling control. It was observed a reduction of 89.6% in the number of eggs and mosquito larvae in establishments that received treatment with Bti, compared to the establishments control. The infestation occurred two months earlier in establishments that did not receive treatment. The Bti was efficient in the mosquito A. aegypti population control in junkyards and recycling centers in tested conditions. It is presented as an alternative for the prevention of dengue, chikungunya and zika virus.
History representations and interpretations in contemporary Lithuanian theatre
Authors: Steiblytė Kristina 
Published: July 2017

The text deals with (re)interpretations of history in professional contemporary Lithuanian theatre.According to historians, nowadays there are few dominating narratives about Lithuanian history: the history of the Grand Duchy of Lithuania with the grand dukes in the forefront, the only Lithuanian king Mindaugas, and the history of the 20th century wars, occupation ant battles for independence. Based on that, the text provides an attempt to figure out how these narratives are represented and reinterpreted in contemporary Lithuanian theatre with the 20th century stories dominating the repertory of historic performances. Those are both confirming the predominant narratives and reinterpreting them and establishing new relation with personalities and events dominant in memory politics. The text also deals with the narrative of the victim that dominates historic Lithuanian self-perception. Two performances help as examples understanding how this narrative can be strengthened or criticised. The last part of the text presents the place that Polish, Russian and Jewish minorities get in contemporary Lithuanian theatre to represent their versions of history and asks whether contemporary Lithuanian theatre is contributing to the creation of a more involving social environment.
Treatment-emergent hypomania possibly associated with over-the-counter supplements
Authors: Olsufka William , Abraham Mary-Ann 
Published: July 2017

Abstract
The use of complementary and alternative medicine (CAM) is gaining popularity in the Western world. Among the general public, CAM is often perceived to be associated with less stigma, fewer adverse effects, and may be more affordable. A number of patients utilize CAM for the treatment of depression; however, as there is limited scientific evidence, the safety profile of these supplements are largely unknown. In this case, a 42-year-old man developed hypomania approximately 1 week after S-adenosylmethionine (SAMe) and 5-hydroxytryptophan (5-HTP) therapy was initiated for depression. The combination of SAMe and 5-HTP can potentially induce hypomanic episodes.
Sphingosine‐1‐phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR‐101 expression
Authors: Tsai Chun‐Hao , Yang Dong‐Ying , Lin Chih‐Yang , Chen Tsung‐Ming , Tang Chih‐Hsin , Huang Yuan‐Li 
Published: July 2017

Chondrosarcoma is the second most common primary malignancy form of bone cancer, exhibiting resistance to chemotherapy and radiation therapy as well as developing high metastasis ability in late‐stage tumors. Thus, understanding the metastatic processes of chondrosarcoma is considered a strategy for the treatment of this disease. Sphingosine 1‐phosphate (S1P), a bioactive sphingolipid, is produced intracellularly by sphingosine kinase (SphK) and is regarded as a second signaling molecule that regulates inflammation, proliferation, angiogenesis, and metastasis. However, the effect of S1P on chondrosarcoma remains uncertain. As demonstrated by the transwell, immunoblotting, and real‐time PCR analyses, we found that S1P inhibited cell migration and MMP‐2 expression through the upregulation of the tissue inhibitor of metalloproteinase‐3 (TIMP‐3) expression in human chondrosarcoma cells. Additionally, we also showed that microRNA (miRNA)‐101, which targets the 3′ untranslated region (3′UTR) of TIMP‐3, decreased significantly following S1P treatment. After transfection with miR‐101 mimics, the S1P‐regulated cell migration and TIMP‐3 expression were both reversed. Furthermore, we also showed that the S1P‐inhibited cell migration is mediated through the c‐Src/MEK/ERK signaling axis. Meanwhile, the in vivo study indicated that overexpression of SphK1 decreases chondrosarcoma metastasis to the lungs. Our results illustrate the clinical significance between SphK1, TIMP‐3, and miR‐101 in human chondrosarcoma patients. Taken together, our results suggest that S1P and miR‐101 may prove to be potential therapeutic targets for future chondrosarcoma treatment.
Prognostic and functional role of subtype‐specific tumor–stroma interaction in breast cancer
Authors: Merlino Giuseppe , Miodini Patrizia , Callari Maurizio , D'Aiuto Francesca , Cappelletti Vera , Daidone Maria Grazia 
Published: July 2017

None of the clinically relevant gene expression signatures available for breast cancer were specifically developed to capture the influence of the microenvironment on tumor cells. Here, we attempted to build subtype‐specific signatures derived from an in vitro model reproducing tumor cell modifications after interaction with activated or normal stromal cells. Gene expression signatures derived from HER2+, luminal, and basal breast cancer cell lines (treated by normal fibroblasts or cancer‐associated fibroblasts conditioned media) were evaluated in clinical tumors by in silico analysis on published gene expression profiles (GEPs). Patients were classified as microenvironment‐positive (μENV+ve), that is, with tumors showing molecular profiles suggesting activation by the stroma, or microenvironment‐negative (μENV−ve) based on correlation of their tumors' GEP with the respective subtype‐specific signature. Patients with estrogen receptor alpha (ER)+/HER2−/μENV+ve tumors were characterized by 2.5‐fold higher risk of developing distant metastases (HR = 2.546; 95% CI: 1.751–3.701, P = 9.84E‐07), while μENV status did not affect, or only suggested the risk of distant metastases, in women with HER2+ (HR = 1.541; 95% CI: 0.788–3.012, P = 0.206) or ER‐/HER2− tumors (HR = 1.894; 95% CI: 0.938–3.824; P = 0.0747), respectively. In ER+/HER2− tumors, the μENV status remained significantly associated with metastatic progression (HR = 2.098; CI: 1.214–3.624; P = 0.00791) in multivariable analysis including size, age, and Genomic Grade Index. Validity of our in vitro model was also supported by in vitro biological endpoints such as cell growth (MTT assay) and migration/invasion (Transwell assay). In vitro‐derived gene signatures tracing the bidirectional interaction with cancer activated fibroblasts are subtype‐specific and add independent prognostic information to classical prognostic variables in women with ER+/HER2− tumors.
Detection of earthquake swarms at subduction zones globally: Insights into tectonic controls on swarm activity
Authors: Nishikawa T. , Ide S. 
Published: July 2017

AbstractEarthquake swarms are characterized by an increase in seismicity rate that lacks a distinguished main shock and does not obey Omori's law. At subduction zones, they are thought to be related to slow‐slip events (SSEs) on the plate interface. Earthquake swarms in subduction zones can therefore be used as potential indicators of slow‐slip events. However, the global distribution of earthquake swarms at subduction zones remains unclear. Here we present a method for detecting such earthquake sequences using the space‐time epidemic‐type aftershock‐sequence model. We applied this method to seismicity (M ≥ 4.5) recorded in the Advanced National Seismic System catalog at subduction zones during the period of 1995–2009. We detected 453 swarms, which is about 6.7 times the number observed in a previous catalog. Foreshocks of some large earthquakes are also detected as earthquake swarms. In some subduction zones, such as at Ibaraki‐Oki, Japan, swarm‐like foreshocks and ordinary swarms repeatedly occur at the same location. Given that both foreshocks and swarms are related to SSEs on the plate interface, these regions may have experienced recurring SSEs. We then compare the swarm activity and tectonic properties of subduction zones, finding that swarm activity is positively correlated with curvature of the incoming plate before subduction. This result implies that swarm activity is controlled either by hydration of the incoming plate or by heterogeneity on the plate interface due to fracturing related to slab bending.