bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Palladium‐Catalyzed Oxidative Cross‐Coupling of α‐Cyanoketene Dithioacetals with Olefins.
Authors: Yang Xiaoge , Liu Zhuqing , Sun Chenglin , Chen Jiping , Yu Zhengkun 
Published: January 2016

Abstractα‐Cyanoketene dithioacetals and a related ketone (IX) readily undergo Pd‐catalyzed oxidative direct olefination with different olefins through C—H activation.
ChemInform Abstract: Asymmetric Michael Addition Reaction of α‐Aryl‐Substituted Lactams Catalyzed by Chiral Quaternary Ammonium Salts Derived from Cinchona Alkaloids: A New Short Synthesis of (+)‐Mesembrine.
Authors: Nunokawa Shiori , Minamisawa Masamitsu , Nakano Keiji , Ichikawa Yoshiyasu , Kotsuki Hiyoshizo 
Published: January 2016

AbstractThe utility of this method is demonstrated in the synthesis of (+)‐mesembrine (VI).
ChemInform Abstract: Synthesis of E‐Alkyl Alkenes from Terminal Alkynes via Ni‐Catalyzed Cross‐Coupling of Alkyl Halides with B‐Alkenyl‐9‐borabicyclo[3.3.1]nonanes.
Authors: Di Franco Thomas , Epenoy Alexandre , Hu Xile 
Published: January 2016

AbstractThe Ni‐catalyzed cross‐coupling of primary and secondary alkyl halides with B‐alkenyl‐9‐borabicyclo[3.3.1]nonanes (II) leads to desired (E)‐alkenes (III) and (V).
ChemInform Abstract: Activation of α‐Diazocarbonyls by Organic Catalysts: Diazo Group Acting as a Strong N‐Terminal Electrophile.
Authors: Li Lei , Chen Jia‐Jia , Li Yi‐Jin , Bu Xiu‐Bin , Liu Qun , Zhao Yu‐Long 
Published: January 2016

AbstractFor the first time, α‐diazocarbonyls are used as highly active N‐terminal electrophiles in the presence of DBU as catalyst.
ChemInform Abstract: Aldehyde‐Promoted One‐Pot Regiospecific Synthesis of Acrylamides Using an in situ Generated Molybdenum Tetracarbonyl Amine [Mo(CO)4(amine)2] Complex.
Authors: Nagarsenkar Atulya , Prajapti Santosh Kumar , Guggilapu Sravanthi Devi , Nagendra Babu Bathini 
Published: January 2016

AbstractThe molybdenum‐amine system acts as both a complexing agent and a CO donor.
ChemInform Abstract: tert‐Butyl Hypochlorite Mediated Oxidative Chlorination of S‐Alkylisothiourea Salts: Synthesis of Sulfonyl Chlorides.
Authors: Qiu Kui , Wang Rennan 
Published: January 2016

AbstractVarious S‐alkylisothiourea salts, in situ obtained from the corresponding alkyl halides or sulfates and thiourea, are converted to alkenesulfonyl chlorides under neutral and environmentally benign reaction conditions.
ChemInform Abstract: Formation of Benzocyclobutenes from Substituted Oxocycloocta‐2,8‐diene‐1,2‐dicarboxylates.
Authors: Bezensek Jure , Groselj Uros , Pockaj Marta , Svete Jurij , Stanovnik Branko 
Published: January 2016

AbstractCyclooctadienes (I) and (III) undergo electrocyclization followed by elimination of dimethylamine.
ChemInform Abstract: Alternate Method for the Synthesis of Six‐Membered Carbocycles with Five Stereocenters: 1,2,3,4,6‐Pentasubstituted‐4‐hydroxy‐cyclohexanes.
Authors: Gezegen Hayreddin , Ceylan Mustafa 
Published: January 2016

AbstractA simple method for the chemoselective synthesis of multisubstituted cyclohexane derivatives from ketones and aldehydes is presented.
ChemInform Abstract: A Practical and General ipso Iodination of Arylboronic Acids Using N‐Iodomorpholinium Iodide (NIMI) as a Novel Iodinating Agent: Mild and Regioselective Synthesis of Aryliodides.
Authors: Tale R. H. , Toradmal G. K. , Gopula V. B. 
Published: January 2016

AbstractA catalytic amount of CuI is found to promote the rate enhancement of the iodination reaction and a drastic increase in the yield depending on the nature of the boronic acid is observed.
ChemInform Abstract: Catalytic Formation of α‐Aryl Ketones by C—H Functionalization with Cyclic Alkenyl Carbonates and One‐Pot Synthesis of Isocoumarins.
Authors: Hara Yusuke , Onodera Shunsuke , Kochi Takuya , Kakiuchi Fumitoshi 
Published: January 2016

AbstractThe Rh‐catalyzed α‐acylalkylation of arenes containing a heteroaryl or amide directing group proceeds in moderate to high yields.
ChemInform Abstract: Amino Acid Salt Catalyzed Asymmetric Synthesis of 1,2‐Diols with a Quaternary Carbon Center.
Authors: Wu Quanquan , Liu Shulei , Wang Fangyuan , Li Qingqing , Cheng Kangli , Li Juan , Jiang Jun 
Published: January 2016

AbstractThe efficient reaction between hydroxyacetone and aryl substituted α‐keto esters provides the products in high yields and with high dia‐ and enantioselectivity.
ChemInform Abstract: An Iron‐Catalyzed Direct Approach to Amides from Benzyl Azides via C—C Bond Cleavage.
Authors: Ou Yang , Qin Chong , Song Song , Jiao Ning 
Published: January 2016

AbstractAlkyl substituted benzyl azides as well as symmetrically substituted arylbenzylazides deliver arylamides in moderate to high yields.
ChemInform Abstract: Palladium‐Catalyzed Enantioselective 1,1‐Fluoroarylation of Aminoalkenes.
Authors: He Ying , Yang Zhenyu , Thornbury Richard T. , Toste F. Dean 
Published: January 2016

AbstractBenzylic fluorides are obtained by a three‐component coupling of unactivated amino‐alkenes, arylboronic acids, and Selectflour through an oxidative Heck mechanism.
ChemInform Abstract: Mild and Soft Catalyzed Trifluoromethylthiolation of Boronic Acids: The Crucial Role of Water.
Authors: Glenadel Quentin , Alazet Sebastien , Tlili Anis , Billard Thierry 
Published: January 2016

AbstractThe reaction tolerates aryl, hetaryl, and alkenyl substituents endowed with a diverse range of functional groups.
ChemInform Abstract: A Metal‐Free Approach to Carboxylic Acids by Oxidation of Alkyl, Aryl, or Heteroaryl Alkyl Ketones or Arylalkynes.
Authors: Aravinda Kumar K. A. , Venkateswarlu Vunnam , Vishwakarma Ram A. , Sawant Sanghapal D. 
Published: January 2016

AbstractA mild and efficient method for the oxidation of various ketones and alkynes to carboxylic acids using Oxone and trifluoroacetic acid is presented.
ChemInform Abstract: Beyond Directed ortho Metalation: Ruthenium‐Catalyzed Amide‐Directed CAr—OMe Activation/Cross‐Coupling Reaction of Naphthamides with Aryl Boronates.
Authors: Zhao Yigang , Snieckus Victor 
Published: January 2016

AbstractThe first catalytic tertiary amide‐directed C—OMe activation/C—C cross‐coupling reaction in the ortho‐methoxy naphthamide series for the synthesis of biaryl and heterobiaryl molecules is reported.
ChemInform Abstract: Syntheses of 2‐Substituted 1‐Amino‐4‐bromoanthraquinones (Bromaminic Acid Analogues) — Precursors for Dyes and Drugs.
Authors: Malik Enas M , Baqi Younis , Mueller Christa E 
Published: January 2016

AbstractThe bromination of 2‐substituted 1‐aminoanthraquinones (I) is the key step of the title synthesis.
ChemInform Abstract: Organocatalytic Enantioselective Cascade Aza‐Michael/Michael Addition Sequence for Asymmetric Synthesis of Chiral Spiro[pyrrolidine‐3,3′‐oxindole]s.
Authors: Zhao Bo‐Liang , Du Da‐Ming 
Published: January 2016

AbstractA wide range of the title spirocompounds are obtained with excellent diastereoselectivity and enantioselectivity using a chiral bifunctional tertiary amine‐squaramide catalyst.
ChemInform Abstract: Exploring the Chemistry of Furans: Synthesis of Functionalized Bis(furan‐2‐yl)methanes and 1,6‐Dihydropyridazines.
Authors: Lopes Susana M. M. , Henriques Marta S. C. , Paixao Jose A. , Pinho e Melo Teresa M. V. D. 
Published: January 2016

AbstractHetero‐Diels‐Alder reactions of hydrazones or oximes with furylmethanes give annulated pyridazines and oxazines, respectively, which are easily transformed into the title compounds.
ChemInform Abstract: An Efficient Synthetic Approach Towards Fully Functionalized Tetronic Acids: The Use of 1,3‐Dioxolane‐2,4‐diones as Novel Protected‐Activated Synthons of α‐Hydroxy Acids.
Authors: Prousis Kyriakos C. , Markopoulos John , Mckee Vickie , Igglessi‐Markopoulou Olga 
Published: January 2016

AbstractUtilization of optically active α‐hydroxy acids allows for the enantiocontrolled preparation of tetronic acids.
ChemInform Abstract: Selective Halogenation of C—H Bonds on Porphyrin Rings Using NaX/H2O2.
Authors: Tian Mi , Chen Shi , Sheng Wenbing , Huang Hui , Guo Cancheng 
Published: January 2016

AbstractThe selective oxidative halogenation of C—H bonds on porphyrins by halides/H2O2 is achieved.
ChemInform Abstract: Enantioselective Palladium‐Catalyzed C—H Functionalization of Indoles Using an Axially Chiral 2,2′‐Bipyridine Ligand.
Authors: Gao Xiang , Wu Bo , Huang Wen‐Xue , Chen Mu‐Wang , Zhou Yong‐Gui 
Published: January 2016

AbstractThese transformations represent the first successful application of bipyridine ligands with axial chirality in palladium‐catalyzed carbene migratory insertion reactions.
ChemInform Abstract: Palladium‐Catalyzed Cycloaminocarbonylation of 2‐Aminomethyl‐ and 2‐Alkylcarbamoylaryl Tosylates with CO.
Authors: Liu Bin , Wang Yan , Liao Benren , Zhang Chunlei , Zhou Xigeng 
Published: January 2016

AbstractThe title reaction allows the synthesis of a wide variety of substituted isoindolinones and isoindoline‐1,3‐diones in moderate to high yields.
ChemInform Abstract: Copper‐Catalyzed Diastereoselective Aerobic Intramolecular Dehydrogenative Coupling of Hydrazones via sp3 C—H Functionalization.
Authors: Wu Xuesong , Wang Mian , Zhang Guangwu , Zhao Yan , Wang Jianyi , Ge Haibo 
Published: January 2016

AbstractThe title reaction gives substituted pyrazolines as the products and it is the first example of Cu‐catalyzed intramolecular diastereoselective coupling reaction via an iminium ion intermediate.
ChemInform Abstract: An Aryne‐Based Route to Substituted Benzoisothiazoles.
Authors: Chen Yiding , Willis Michael C. 
Published: January 2016

AbstractThe reaction of 3,4‐disubstituted thiadiazoles with arynes, generated in situ from corresponding 2‐(trimethylsilyl)aryl triflates (II), leads to desired 3‐substituted benzoisothiazoles in moderate to high yields.
ChemInform Abstract: Synthesis of 6‐Aryl‐4H‐imidazo[1,2‐b][1,2,4]triazoles and 6‐Aryl‐thiazolo[3,2‐b][1,2,4]triazoles.
Authors: Krishnaraj T. , Muthusubramanian S. 
Published: January 2016

AbstractSome of the bicyclic products exhibit antibacterial activity.
ChemInform Abstract: A Mild and Efficient Route to 3‐Vinylchromones in Aqueous Micellar Media.
Authors: Kumar Vikash , Chatterjee Amrita , Banerjee Mainak 
Published: January 2016

AbstractBy a simple and mild procedure pharmacologically interesting 3‐formylchromanes are synthesized in micellar solution by Knoevenagel condensation with various active methylene compounds.
ChemInform Abstract: Transition Metal‐Free Oxidative Radical Decarboxylation/Cyclization for the Construction of 6‐Alkyl/Aryl Phenanthridines.
Authors: Lu Shichao , Gong Yaling , Zhou Demin 
Published: January 2016

AbstractA novel cascade decarboxylation/cyclization reaction of 2‐isocyanobiphenyls with aliphatic and aromatic carboxylic acids under transition metal‐free conditions is reported.
ChemInform Abstract: One‐Pot, Three‐Component Synthesis of 1,8‐Naphthyridine Derivatives from Heterocyclic Ketene Aminals, Malononitrile Dimer, and Aryl Aldehydes.
Authors: Sun Feilong , Zhu Fengjuan , Shao Xusheng , Li Zhong 
Published: January 2016

AbstractEthyl 2‐imidazolidinylideneacetate and 2‐imidazolidinylideneacetonitrile do not react possibly due to the weaker electron‐withdrawing capability compared to NO2.
ChemInform Abstract: Efficient Synthesis of Nb‐Thioacyltryptamine Derivatives by a Three‐Component Willgerodt—Kindler Reaction, and Their Transformation to 1‐Substituted‐3,4‐dihydro‐β‐carbolines.
Authors: Milen Matyas , Slegel Peter , Keglevich Peter , Keglevich Gyoergy , Simig Gyula , Volk Balazs 
Published: January 2016

AbstractThe synthesis of tryptamine derivatives (III) is advantageous with regards to wide substrate scope, good yields, and short reaction times.
ChemInform Abstract: Application of Design of Experiments (DoE) Optimization to the One‐Pot Synthesis of 4,6‐Dihydropteridinones.
Authors: Stone Steven , Wang Tiansheng , Liang Jianglin , Cochran John , Green Jeremy , Gu Wenxin 
Published: January 2016

AbstractA one‐pot procedure to synthesize title compounds such as (III), (V), (VII), and (IX) from pyrimidines (I) and amino acid derivatives is studied and the reaction parameters are optimized.
ChemInform Abstract: Selective Friedel—Crafts Acylation Reactions of 2‐Arylphenoxyacetic Acids: A Simple and Efficient Methodology to Synthesize Dibenzoxepine and Arylcoumaranone Derivatives.
Authors: Wang Jialin , Liu Jiaqi , Lan Hao , Chu Wenyi , Sun Zhizhong 
Published: January 2016

AbstractThe synthesis of the substrates via Suzuki—Miyaura coupling of substituted 2‐(2‐bromophenoxy)acetates with various aryl boronic acids is described.
ChemInform Abstract: DABCO‐Mediated [4 + 4]‐Domino Annulation: Access to Functionalized Eight‐Membered Cyclic Ethers.
Authors: Liang Ling , Li Erqing , Dong Xuelin , Huang You 
Published: January 2016

AbstractDABCO‐mediated reaction of ynones such as (I) with α‐cyano‐α,β‐unsaturated ketones affords eight‐membered cyclic ethers (III) (21 examples) in good yields under mild conditions.
ChemInform Abstract: anti‐HIV Terpenoids from Daphne aurantiaca Diels. Stems.
Authors: Huang Sheng‐Zhuo , Zhang Xuan , Ma Qing‐Yun , Zheng Yong‐Tang , Dai Hao‐Fu , Wang Qi , Zhou Jun , Zhao You‐Xing 
Published: January 2016

AbstractA series of terpenoids including new (six guaiane type auranticanols A‐F and seven carotene type auranticanols G‐M), and known (14 examples) sesquiterpenoids, and known tigliane diterpenoids are isolated from the stems of Daphne aurantiaca Diels.
ChemInform Abstract: α‐C‐Glycosides via syn Opening of 1,2‐Anhydro Sugars with Organozinc Compounds in Toluene/n‐Dibutyl Ether.
Authors: Wagschal Simon , Guilbaud Johan , Rabet Pauline , Farina Vittorio , Lemaire Sebastien 
Published: January 2016

AbstractThe diastereoselective addition of organozinc species to 1,2‐anhydro sugars in toluene/n‐dibutyl ether solvent is reported.
ChemInform Abstract: Organo‐Zinc Promoted Diastereoselective C‐Arylation of 1,2‐Anhydrosugars from Arylboronic Acids.
Authors: Tatina Madhu Babu , Kusunuru Anil Kumar , Mukherjee Debaraj 
Published: January 2016

AbstractThe title reaction features broad substrate scope, milder reaction conditions, complete α‐selectivity, and no need of using ligand and base.
ChemInform Abstract: Bromotyrosine‐Derived Alkaloids from the Caribbean Sponge Aplysina lacunosa.
Authors: Goethel Qun , Sirirak Thanchanok , Koeck Matthias 
Published: January 2016

AbstractThree new alkaloids, deoxyfistularin‐3 (I), aplysinin A (II), and aplysinin B (III), together with other 15 known compounds are isolated from title sponge.
ChemInform Abstract: Antiinflammatory Alkaloid Glycoside and Quinoline Alkaloid Derivates from the Stems of Clausena lansium.
Authors: Liu Jie , Li Chuang‐Jun , Ni Lin , Yang Jing‐Zhi , Li Li , Zang Cai‐xia , Bao Xiu‐Qi , Zhang Dan , Zhang Dong‐Ming 
Published: January 2016

AbstractSix new alkaloid glycosides, clausenasides A‐F, and two novel quinoline alkaloids, clausenasides G‐H, are isolated along with ten known compounds from the stems of C.
ChemInform Abstract: Solar Thermochemical Energy Storage Through Carbonation Cycles of SrCO3/SrO Supported on SrZrO3.
Authors: Rhodes Nathan R. , Barde Amey , Randhir Kelvin , Li Like , Hahn David W. , Mei Renwei , Klausner James F. , AuYeung Nick 
Published: January 2016

AbstractEquimolar amounts of SrO and 8 mol% Y2O3‐stabilized ZrO2 (YSZ) as a support material are fired in air (1500 °C, 8 h) to produce Y‐stabilized SrZrO3 for use as sintering inhibitor for a thermochemical storage system based on SrO/SrCO3 carbonation cycles.
ChemInform Abstract: Recent Advances in Transition‐Metal‐Catalyzed Silylations of Arenes with Hydrosilanes: C—X Bond Cleavage or C—H Bond Activation Synchronized with Si—H Bond Activation
Authors: Xu Zheng , Huang Wei‐Sheng , Zhang Jin , Xu Li‐Wen 
Published: January 2016

AbstractReview: [70 refs.
Cysteine Radical/Metal Ion Adducts: A Gas‐Phase Structural Elucidation and Reactivity Study
Authors: Lesslie Michael , Lau Justin Kai‐Chi , Lawler John T. , Siu K. W. Michael , Steinmetz Vincent , Maître Philippe , Hopkinson Alan C. , Ryzhov Victor 
Published: January 2016

AbstractThe formation and investigation of sulfur‐based cysteine radicals cationized by a group 1A metal ion or Ag+in the gas phase are reported. Gas‐phase ion–molecule reactions (IMR) and infrared multiple‐photon dissociation (IRMPD) spectroscopy revealed that the Li+, Na+, and K+adducts of the cysteine radical remain S‐based radicals as initially formed. Theoretical calculations for the three alkali metal ions found that the lowest‐energy isomers are Cα‐based radicals, but they are not observed experimentally owing to the barriers associated with the hydrogen‐atom transfer. A mechanism for the S‐to‐Cαradical rearrangement in the metal ion complexes was proposed, and the relative energies of the associated energy barriers were found to be Li+>Na+>K+at all levels of theory. Relative to the B3LYP functional, other levels of calculation gave significantly higher barriers (by 35–40 kJ mol−1at MP2 and 44–47 kJ mol−1at the CCSD level) using the same basis set. Unlike the alkali metal adducts, the cysteine radical/Ag+complex rearranged from the S‐based radical to an unreactive species as indicated by IMRs and IRMPD spectroscopy. This is consistent with the Ag+/cysteine radical complex having a lower S‐to‐Cαradical conversion barrier, as predicted by the MP2 and CCSD levels of theory.
Developmental nicotine exposure disrupts dendritic arborization patterns of hypoglossal motoneurons in the neonatal rat
Authors: Powell Gregory L. , Gaddy Joshua , Xu Fei , Fregosi Ralph F. , Levine Richard B. 
Published: January 2016

ABSTRACTMaternal smoking or use of other products containing nicotine during pregnancy can have significant adverse consequences for respiratory function in neonates. We have shown, in previous studies, that developmental nicotine exposure (DNE) in a model system compromises the normal function of respiratory circuits within the brainstem. The effects of DNE include alterations in the excitability and synaptic interactions of the hypoglossal motoneurons, which innervate muscles of the tongue. This study was undertaken to test the hypothesis that these functional consequences of DNE are accompanied by changes in the dendritic morphology of hypoglossal motoneurons. Hypoglossal motoneurons in brain stem slices were filled with neurobiotin during whole‐cell patch clamp recordings and subjected to histological processing to reveal dendrites. Morphometric analysis, including the Sholl method, revealed significant effects of DNE on dendritic branching patterns. In particular, whereas within the first five postnatal days there was significant growth of the higher‐order dendritic branches of motoneurons from control animals, the growth was compromised in motoneurons from neonates that were subjected to DNE. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1125–1137, 2016
A Tie2‐driven BAC‐TRAP transgenic line for in vivo endothelial gene profiling
Authors: Santhosh Devi , Huang Zhen 
Published: January 2016

SummaryRecent technological innovations including bacterial artificial chromosome‐based translating ribosome affinity purification (BAC‐TRAP) have greatly facilitated analysis of cell type‐specific gene expression in vivo, especially in the nervous system. To better study endothelial gene expression in vivo, we have generated a BAC‐TRAP transgenic mouse line where the L10a ribosomal subunit is tagged with EGFP and placed under the control of the endothelium‐specific Tie2 (Tek) promoter. We show that transgene expression in this line is widely, but specifically, detected in endothelial cells in several brain regions throughout pre‐ and postnatal development, as well as in other organs. We also show that this line results in highly significant enrichment of endothelium‐specific mRNAs from brain tissues at different stages. This BAC‐TRAP line therefore provides a useful genetic tool for in vivo endothelial gene profiling under various developmental, physiological, and pathological conditions. genesis 54:136–145, 2016. © 2016 Wiley Periodicals, Inc.
Identification of a G-Protein Subunit-α11 Gain-of-Function Mutation, Val340Met, in a Family With Autosomal Dominant Hypocalcemia Type 2 (ADH2)
Authors: Piret Sian E , Gorvin Caroline M , Pagnamenta Alistair T , Howles Sarah A , Cranston Treena , Rust Nigel , Nesbit M Andrew , Glaser Ben , Taylor Jenny C , Buchs Andreas E , Hannan Fadil M , Thakker Rajesh V 
Published: January 2016

ABSTRACT

Autosomal dominant hypocalcemia (ADH) is characterized by hypocalcemia, inappropriately low serum parathyroid hormone concentrations and hypercalciuria. ADH is genetically heterogeneous with ADH type 1 (ADH1), the predominant form, being caused by germline gain-of-function mutations of the G-protein coupled calcium-sensing receptor (CaSR), and ADH2 caused by germline gain-of-function mutations of G-protein subunit α-11 (Gα11). To date Gα11 mutations causing ADH2 have been reported in only five probands. We investigated a multigenerational nonconsanguineous family, from Iran, with ADH and keratoconus which are not known to be associated, for causative mutations by whole-exome sequencing in two individuals with hypoparathyroidism, of whom one also had keratoconus, followed by cosegregation analysis of variants. This identified a novel heterozygous germline Val340Met Gα11 mutation in both individuals, and this was also present in the other two relatives with hypocalcemia that were tested. Three-dimensional modeling revealed the Val340Met mutation to likely alter the conformation of the C-terminal α5 helix, which may affect G-protein coupled receptor binding and G-protein activation. In vitro functional expression of wild-type (Val340) and mutant (Met340) Gα11 proteins in HEK293 cells stably expressing the CaSR, demonstrated that the intracellular calcium responses following stimulation with extracellular calcium, of the mutant Met340 Gα11 led to a leftward shift of the concentration-response curve with a significantly (p &lt; 0.0001) reduced mean half-maximal concentration (EC50) value of 2.44 mM (95% CI, 2.31 to 2.77 mM) when compared to the wild-type EC50 of 3.14 mM (95% CI, 3.03 to 3.26 mM), consistent with a gain-of-function mutation. A novel His403Gln variant in transforming growth factor, beta-induced (TGFBI), that may be causing keratoconus was also identified, indicating likely digenic inheritance of keratoconus and ADH2 in this family. In conclusion, our identification of a novel germline gain-of-function Gα11 mutation, Val340Met, causing ADH2 demonstrates the importance of the Gα11 C-terminal region for G-protein function and CaSR signal transduction. © 2016 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research (ASBMR).