bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethanolic Extract of Hedyotis corymbosa and Its Combination with 5-FU Inhibit Cyclin D Expression on WiDr Colorectal Cancer Cell
Authors: Meiftasari Argandita , W.P. Januar Caesar , Novarina Annisa , W. Julika Yovi , Jenie Riris Istighfari 
Published: January 2018

Hedyotis corymbosa has been used for long time as an important component in several folklore medicine formula to clinically treat various types of cancer, including colorectal cancer (CRC). Previously, Hedyotis corymbosa ethanolic extract (HEE) which contain ursolic acid reported to inhibit CRC growth via induction of cancer cell apop­tosis and blocked the cell cycle, preventing G1 to S progression where cyclin D highly espressed in this phase. 5-fluorouracil (5FU), the first line chemotherapy of colorectal cancer have had resistence and possessed several side effects such as neutropenia, immunosuppression, diarrhea, and also constipation. Therefore, the aim of this research is to conduct the antiproliferative effect and molecular analysis of HEE and its combination with 5FU. Molecular docking study was also done to approach the specific protein target of the compound. Antiproliferative effect was conducted by MTT assay, while cyclin D expression was examined by immunofluorescence. The proliferative effect showed that both HEE and 5-FU had cytotoxic effect with IC50 value of 65 µg/mL and 90 µM respectively, meanwhile the combination of HEE and 5FU have synergism effect with CI = 0.48 on dose HEE = 22 µg/mL and 5FU= 6.25 µM. Immunofluorescence assay showed HEE and its combination with 5FU suppressed the expression of cyclin D. From molecular docking simulation, ursolic acid performed stable interaction with cyclin D. Our findings suggest that HEE may be an effective treat­ment for co-chemotherapic for 5-FU through inhibition of cyclin D expression.Keywords : Hedyotis corymbosa, 5-fluorouracil, colorectal cancer, WiDr, cyclin D
Anti-Aging Activity Of Cucurbita moschata Ethanolic Extract Towards NIH3T3 Fibroblast Cells Induced By Doxorubicin
Authors: Muntafiah Laeli , Shabrina Bani Adlina , Sulistyowati Dwi , Asshagab Murah Riski Novi , Jenie Riris Istighfari 
Published: January 2018

Degenerative disease caused by decreasing organ function in old people has become the biggest death cause in the world. This aging process marked by senescence activity. An anti-aging agent from the medicinal plant has high potency to be developed, such as pumpkin seed (Cucurbita moschata) which contain tocopherol as antioxidant. The aim of this study is to investigate the anti-aging effect of pumpkin seed extract (PSE) on NIH 3T3 fibroblast normal cell induced by doxorubicin. This anti-aging effect was observed using MTT assay continued by SA- βgal (Senescence-Associated Beta-Galactosidase) activity detection test. The stability of molecular interaction between tocopherol and doxorubicin to CYP 3A4 as the oxidase enzyme was conducted using molecular docking. Based on in vitro test, PSE is not cytotoxic to NIH 3T3. PSE at the dose of 100,200,400, and 800 μg/mL decreased % cell senescence by 2,77; 4,5; 6; and 18 times respectively. Meanwhile, in silico test indicated that tocopherol (-107,409) has a higher interaction to CYP 3A4 compared to doxorubicin (-70,52). Both compounds have a similar binding site in Leu 364; Phe 435; Pro 434; Cys 442; Ile 369; Thr 309; dan Ala 305. The overall result of this study showed that PSE has anti-aging effect by decreasing SA- βgal activity. This anti-aging activity possibly due to the interaction between tocopherol to CYP 3A4 based on molecular docking.Keywords: anti-aging, Cucurbita moschata, tocopherol, SA-βgal, molecular docking
Heartwood of Secang (CAESALPINIA SAPPAN L.) Ethanolic Extract Show Selective Cytotoxic Activities on T47D and Widr Cells But Not on Hela Cells
Authors: Rivanti Erlina , Shabrina Bani Adlina , Nurzijah Ika , Ayu Cyndwika , Hermawan Adam 
Published: January 2018

The present study investigate the selectivity of heartwood of secang ethanolic extract (SEE) on T47D breast cancer cells, WiDr colon cancer cells, and HeLa cervical cancer cells, compared to Vero normal epithelial cells. The cytotoxic effect was evaluated by using MTT assay with 24-hour treatment to get IC50values. Selectivity was evaluated by using selectivity index (SI). SEE had a potent cytotoxic activity on T47D and WiDr cancer cells (IC50 <100 µg/ml). IC50 value of HeLa cancer cells was observed on moderate cytotoxic (100 <IC50 <1000 µg/ml). SEE demonstrated more selective to T47D and WiDr than Vero cells (SI > 3), while in HeLa cells is not selective (SI < 3). This result indicating its potential of Caesalpinia sappan as a chemopreventive agent in cancer therapy.Keywords: Cancer, selectivity, Secang, T47D, WiDr, HeLa, Vero
Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol
Authors: Yuliani Ni Nyoman , Sambara Jefrin , Hilaria Maria , Harlinda Harlinda 
Published: January 2018

Indonesia has biodiversity potential to be developed as medicinal plants, such as basil leaves (Ocimum sanctum L.). Basil was reported to have a very high antioxidant activity in vitro. The aim of this study was to determine the effect of basil leaves (Ocimum sanctum L.) infusion to liver based Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) value in each dose. 18 rats were divided into 6 groups., control group, negative control group treated with CMC Na 0.5%, positive control group treated with Curcuma 3.6 mg / 200gBB, groups of 4-6 consecutive given a 80 mg dose infusion basil / 200 gBB, 160 mg / 200 gBB, 320 mg / 200 gBB for 8 consecutive days, on the day of the 4th and 8th all treatment groups induced by toxic doses of paracetamol (500 mg / 200 gBB) except the normal control group 1, The research data in the form of enzyme activity of AST and ALT were analyzed using parametric and nonparametric ANOVA, and Friedman test with the level of trust then followed by SNK test and Bnj test. The statistical test result with a 95% of level of trust that shown basil infuse with a dose of 80mg / 200gBB, 160mg / 200gBB, 320mg / 200gBB have hepatoprotective effects in rats induced by paracetamol 500mg / 200gBB. Based on the result of changes in average levels of AST on the fourth day and the eighth day of the three treatment infusion, infusion at a dose of 160 mg / 200gBB most effectively reduce average levels of AST and a group that has the average AST closest to the control group is positive, but infusion at a dose of 320mg / 200gBB the group that has the closest average ALT positive control group.Keywords : hepatoprotective, Ocimum sanctum L, Paracetamol
State of the literature on the economic impacts of climate change in the United States
Authors: Neumann James E. , Strzepek Kenneth 
Published: January 2018

Abstract:This paper discusses the current literature on impacts and adaptation costs at the sectoral level. The focus is primarily the US, but includes examples on international applications that highlight key differences or other relevant demonstrations of method and data use. The paper provides an overall framework that addresses the components of economic impacts, including definitions of impacts, adaptation costs, and residual damages. The paper then focuses on understanding the current breadth and depth of the literature that exists to characterize what we know about economic sectors studied in the recent literature (agriculture, coastal resources, water resources, infrastructure, health, crime, energy, labor productivity, and ecosystems), how the methodologies differ, what the gaps and challenges are, and offers a sense of the impacts at the US national level. A new generation of impact studies, including the U.S. EPA’s ongoing Climate Impacts and Risk Analysis (CIRA) project; the new Intergovernmental Panel on Climate Change (IPCC) AR5 Working Group II report; the U.S. National Climate Assessment; and the Risky Business Project led by the Next Generation Foundation, provide the motivation for this review. These efforts, taken together, have advanced the state of US economic impact assessment work along two critical frontiers, both of which support benefit-cost analyses of climate change: assessment of the risk and economic consequences of extreme climatic events; and assessment of ecosystem effects. Yet, the latest work also highlights gaps in the lack of comprehensive sectoral coverage; more complete incorporation of adaptation opportunities in impact assessment; and critical cross- and multi-sectoral effects that remain poorly understood.
Embedding (some) benefit-cost concepts into decision support processes with deep uncertainty
Authors: Lempert Robert J. 
Published: January 2018

Abstract:Benefit-cost analysis (BCA) aims to help people make better decisions. But BCA does not always serve this role as well as intended. In particular, BCA’s aim of aggregating all attributes of concern to decision makers into a single, best-estimate metric can conflict with the differing world views and values that may be an inherent characteristic of many climate-related decisions. This paper argues that new approaches exist that can help reduce the tension between the benefits of providing useful, scientifically based information to decision makers and the costs of aggregating uncertainty and differing values into single best estimates. Enabled by new information technology, these approaches can summarize decision-relevant information in new ways. Viewed in this light, many limitations of BCA lie not in the approach itself, but with the way it is used. In particular, this paper will argue that the problem lies in a process that begins by first assigning agreed-upon values to all the relevant inputs and then using BCA to rank the desirability of alternative decision options. In contrast, BCA can be used as part of a process that begins by acknowledging a wide range of ethical and epistemological views, examines which combinations of views are most important in affecting the ranking among proposed decision options, and uses this information to identify and seek consensus on actions that are robust over a wide range of such views.
Load-Power Relationship During a Countermovement Jump: A Joint Level Analysis
Authors: Williams Kym J. , Chapman Dale W. , Phillips Elissa J. , Ball Nick B. 
Published: January 2018

Abstract
Williams, KJ, Chapman, DW, Phillips, EJ, and Ball, N. Load-power relationship during a countermovement jump: A joint level analysis. J Strength Cond Res 32(4): 955–961, 2018—This study aimed to investigate whether hip, knee, and ankle peak power is influenced by the relative load lifted, altering the joint and system load-power relationship during a countermovement jump (CMJ). Twenty-three male national representative athletes (age: 20.3 ± 3.1 years, squat 1 repetition maximum [1RM]: 133.8 ± 24.8 kg) completed 3 CMJs at relative barbell loads of 0, 10, 20, 30, and 40% of an athlete's estimated back squat 1RM. Ground reaction force and joint kinematics were captured using a 16 camera motion capture array integrated with 2 in-ground triaxial force plates. Hip (

JOURNAL/jscr/04.03/00124278-201804000-00009/inline-formula1/v/2023-08-19T002751Z/r/image-tiff

= 20%, range 0 > 40%), knee (

JOURNAL/jscr/04.03/00124278-201804000-00009/inline-formula2/v/2023-08-19T002751Z/r/image-tiff

= 0%, 0 > 20%), and ankle (

JOURNAL/jscr/04.03/00124278-201804000-00009/inline-formula3/v/2023-08-19T002751Z/r/image-tiff

= 40%, 0 > 40%) peak power was maximized at different percentages of absolute strength, with an athlete-dependent variation in load-power profiles observed across all lower-body joints. A decrease in system (body + barbell mass) peak power was significantly (p ≤ 0.05, r = 0.45) correlated with a reduction in knee peak power. Timing of instantaneous system and hip peak power occurred significantly closer to toe-off as load increased. The findings highlight that the generation and translation of lower-body joint power is influenced by external load and athlete-dependent traits. This subsequently alters the load-power profile at a system level, explaining the broad spectrums of loads reported to optimize system power during a CMJ. When training, we recommend that a combination of barbell loads based on assorted percentages of the estimated 1RM be prescribed to optimize joint and system power during a CMJ.
Sox2 Is Essential for Oligodendroglial Proliferation and Differentiation during Postnatal Brain Myelination and CNS Remyelination
Authors: Zhang Sheng , Zhu Xiaoqing , Gui Xuehong , Croteau Christopher , Song Lanying , Xu Jie , Wang Aijun , Bannerman Peter , Guo Fuzheng 
Published: January 2018

In the CNS, myelination and remyelination depend on the successful progression and maturation of oligodendroglial lineage cells, including proliferation and differentiation of oligodendroglial progenitor cells (OPCs). Previous studies have reported that Sox2 transiently regulates oligodendrocyte (OL) differentiation in the embryonic and perinatal spinal cord and appears dispensable for myelination in the postnatal spinal cord. However, the role of Sox2 in OL development in the brain has yet to be defined. We now report that Sox2 is an essential positive regulator of developmental myelination in the postnatal murine brain of both sexes. Stage-specific paradigms of genetic disruption demonstrated that Sox2 regulated brain myelination by coordinating upstream OPC population supply and downstream OL differentiation. Transcriptomic analyses further supported a crucial role of Sox2 in brain developmental myelination. Consistently, oligodendroglial Sox2-deficient mice developed severe tremors and ataxia, typical phenotypes indicative of hypomyelination, and displayed severe impairment of motor function and prominent deficits of brain OL differentiation and myelination persisting into the later CNS developmental stages. We also found that Sox2 was required for efficient OPC proliferation and expansion and OL regeneration during remyelination in the adult brain and spinal cord. Together, our genetic evidence reveals an essential role of Sox2 in brain myelination and CNS remyelination, and suggests that manipulation of Sox2 and/or Sox2-mediated downstream pathways may be therapeutic in promoting CNS myelin repair.SIGNIFICANCE STATEMENTPromoting myelin formation and repair has translational significance in treating myelin-related neurological disorders, such as periventricular leukomalacia and multiple sclerosis in which brain developmental myelin formation and myelin repair are severely affected, respectively. In this report, analyses of a series of genetic conditional knock-out systems targeting different oligodendrocyte stages reveal a previously unappreciated role of Sox2 in coordinating upstream proliferation and downstream differentiation of oligodendroglial lineage cells in the mouse brain during developmental myelination and CNS remyelination. Our study points to the potential of manipulating Sox2 and its downstream pathways to promote oligodendrocyte regeneration and CNS myelin repair.
Il contratto turistico sportivo
Authors: Cimmino Maria 
Published: January 2018

Negli ultimi tempi si è assistito alla diffusione di una particolare forma di interrelazione tra sport e turismo rappresentata dal cosiddetto “Turismo Sportivo”, espressione con la quale si vuole designare l’associazione dell’esperienza sportiva al viaggio, solitamente motivato dall’interesse allo svago, al divertimento all’occupazione del tempo libero e al miglioramento del benessere psicofisico. Sul piano della tutela diritti della personalità, esiste un minimo comune denominatore, una trade union fra sport e turismo, costituito dal godimentod el tempo libero. Se si guarda alla regolamentazione dei rapporti contrattuali che hanno la loro giustificazione causale nello spostamento e nel viaggio, si scorge un’ulteriore rilevanza del tempo libero che si esprime nel particolare collegamento tra sport e turismo. Alla luce della giurisprudenza italiana formatasi in tema di causa in concreto del contratto, detto legame, sebbene non esplicitato in un tipo contrattuale a se stante, porta l’interprete a riflettere sulla figura che potremmo definire del contratto turistico- sportivo.Obiettivo del presente lavoro, in tal senso, è verificare, dal punto di vista della tipologia dei servizi offerti, quanto la presenza tra le varie prestazioni acquistate dal viaggiatore di un servizio turistico possa incidere sull’attuazione del rapporto contrattualee sui conensis strumenti di tutela dellos protivo della vacanza, anche in relazione alla professionalità dei terzi prestatori di servizi.
Az albumin prognosztikai jelentősége az onkológiában
Authors: Deme Dániel , Telekes András 
Published: January 2018

Abstract: Diminished serum albumin level can be observed in inflammatory processes. Serum albumin level also reduces – irrespective of the presence of malnutrition – in locally advanced or metastatic malignancies. Low serum albumin level may have an influence also on the results of anticancer therapy (e.g., drug pharmacokinetics, adverse drug reactions). Extensive data of the literature and empirical experience prove the better prognosis of patients involved in nutritional therapy. Based on the most relevent data of the literature, the authors summarize the studies which have revealed the close correlation between the baseline serum albumin level and the prognosis of malignant diseases. Orv Hetil. 2018; 159(3): 96–106.
A kiégésszindróma vizsgálata a Szegedi Tudományegyetem, Sürgősségi Betegellátó Önálló Osztály dolgozóinak körében
Authors: Hompoth Emőke Adrienn , Töreki Annamária , Pető Zoltán 
Published: January 2018

Abstract: Introduction: Burnout has been described as a growing problem amongst healthcare workers. Emergency department staffs experience the burden of stress day by day, yet only a few studies have examined their burnout. Aim: In this study we wanted to investigate the burnout and its relations to other variables amongst the employees of the Department of Emergency Medicine in Szeged. Method: Cross-sectional design utilizing a self-administered questionnaire was used to collect data from the staff of the Department. Burnout was measured using the Maslach Burnout Inventory. Results: Burnout is considerably prevalent among the workers of the Emergency Department, especially nurses and physicians. The study found negative relation between burnout and age, number of children, number of years in the healthcare system, number of physical symptoms, social support and psychological immune system. Being single was a risk factor. Conclusions: The risks and protective factors found to be associated with burnout in this study might help to set up institutional prevention and intervention strategies. Orv Hetil. 2018; 159(3): 113–118.
Az interatrialis blokk és klinikai jelentősége. Egy EKG-entitás reneszánsza
Authors: Tomcsányi János 
Published: January 2018

Abstract: Interatrial block involves conduction delay between the right and left atria during sinus rhythm. The review describes the classification, pathomechanism and clinical significance of this under-recognised ECG sign, nominated Bayés syndrome. The presented ECGs help to recognise the differentypes of interatrial blocks. Orv Hetil. 2018; 159(3): 91–95.
Az autoimmun encephalitisek laboratóriumi vizsgálati lehetőségei
Authors: Böröcz Katalin , Hayden Zsófia , Mészáros Viktória , Csizmadia Zsuzsanna , Farkas Kornélia , Kellermayer Zoltán , Balogh Péter , Nagy Ferenc , Berki Tímea 
Published: January 2018

Abstract: Introduction: The role of autoimmune responses against central nervous system (CNS) antigens in encephalitis presenting with non-classified neurologic or psychiatric symptoms has been appreciated in the past decade. Paraneoplastic limbic encephalitis has a poor prognosis and is most commonly associated with lung, ovarium, and testicular neoplasms, leading to immune reactions against intracellular antigens (anti-Hu/ANNA1, anti-Ri/ANNA2, anti-CV2/CRMP5 and anti-Ma2/Ta). In contrast, the recently described autoimmune encephalitis subtypes present with a broad spectrum of symptoms, respond to autoimmune therapies well and usually associate with autoantibodies against neuronal cell surface receptors (NMDAR, GABABR, AMPAR) or synaptic proteins (LGI1, CASPR2). Aim: Our aim is to bring to awareness the increasing number of autoimmune encephalitis patients requiring neurologic, psychiatric and intensive care and to emphasize the significance of detecting various autoantibodies in diagnosing patients. Method: In the past 6 years, our laboratory received 836 autoimmune encephalitis diagnostic test requests from a total of 717 patients. Serum and cerebrospinal fluid (CSF) samples were analysed with indirect immunofluorescence using a BIOCHIP consisting of cell lines transfected with 6 different receptor proteins. Results: IgG autoantibodies against receptor proteins were present in 7.5% of patients. The frequency of positive samples was the following: NMDAR > LGI1 > GABABR > CASPR2. Conclusion: Detecting autoantibodies facilitates the diagnosis of autoimmune encephalitis in an early stage. Patients diagnosed early can be effectively treated with plasmapheresis and immunosuppressive drugs. The efficiency of therapies can be monitored by autoantibody detection. Therefore, the diagnostic immune laboratory plays an important role in proper diagnosis and in the prevention of rapidly progressing symptoms. Orv Hetil. 2018; 159(3): 107–112.
SAÚDE MENTAL NA ATENÇÃO BÁSICA: ANAIS DO CONGRESSO BRASILEIRO DE ENFERMAGEM
Authors: Dos Santos Renato Eiji Bellocchi , Nóbrega Maria Do Perpétuo Socorro de Sousa 
Published: January 2018

<p>Objetivo: caracterizar a produção científica de enfermeiros sobre a Saúde Mental na Atenção Básica publicada nos anais do Congresso Brasileiro de Enfermagem. Método: estudo qualitativo, exploratório e de revisão de literatura dos anais do Congresso Brasileiro de Enfermagem do período compreendido entre 2009 a 2014. Resultados: foram<br />analisados 70 resumos, a maioria proveniente da região Nordeste do país (54,3%). Os resumos foram agrupados em categorias: Experiências da assistência à saúde mental de indivíduos e famílias; Saúde Mental na perspectiva dos profissionais da Atenção Básica; e Organização e operacionalização da Saúde Mental na Atenção Básica. Conclusão: o avanço da Reforma Psiquiátrica e a expansão da Estratégia de Saúde da Família provavelmente influenciam a produção de trabalhos acerca da temática. A análise da produção científica investigada indica que há um movimento no sentido de fortalecer a articulação de dois campos em construção para atingir os pressupostos das políticas vigentes.</p><p><br />Descritores: Saúde mental. Atenção Primária à Saúde. Enfermagem.</p>
HOMICÍDIOS NA POPULAÇÃO MASCULINA DA REGIÃO METROPOLITANA DE SÃO PAULO – BRASIL
Authors: Santos Fransley Lima , Cordeiro Ricardo Carlos 
Published: January 2018

<p>Objetivo: descrever a tendência dos homicídios na população masculina residente na Região Metropolitana de São Paulo, Brasil, entre os anos de 1979 e 2013. Método: estudo ecológico, exploratório de tendência temporal com descrição da evolução temporal e distribuição espacial dos óbitos por homicídios. Analisou-se as mortes e os coeficientes de mortalidade da população masculina ocorrida na Região Metropolitana de São Paulo decorrentes de homicídios. Resultados: as mortes predominaram entre adolescentes e adultos jovens, com aumento a<br />partir dos 14 anos de idade. O coeficiente de mortalidade por homicídios masculinos foi maior do que a média nacional até 2005, invertendo-se a partir desse ano. Conclusão: os homicídios na Região Metropolitana de São Paulo tiveram um comportamento peculiar em relação ao Brasil e ao estado de São Paulo até o início de 2005, merecendo um estudo detalhado e minucioso dos eventos que cooperaram para a redução dos homicídios nesta região.</p><p><br />Descritores: Homicídio. Vítimas de homicídio. Violência. Mortalidade. Homens.</p>