bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theory about the Embryo Cryo‐Treatment
Authors: Vladimirov Iavor K. , Tacheva Desislava , Diez Antonio 
Published: April 2017

AbstractBackgroundTo create hypothesis, which can give a logical explanation related to the benefits of freezing/thawing embryos. Cryopreservation is not only a technology used for storing embryos, but also a method of embryo treatment that can potentially improve the success rate in infertile couples.MethodsFrom the analysis of multiple results in assisted reproductive technology, which have no satisfactory explanation to date, we found evidence to support a ‘therapeutic’ effect of the freezing/thawing of embryos on the process of recovery of the embryo and its subsequent implantation.ResultsFreezing/thawing is a way to activate the endogenous survival and repair responses in preimplantation embryos. Several molecular mechanisms can explain the higher success rate of ET using thawed embryos compared to fresh ET in women of advanced reproductive age, the higher miscarriage rate in cases of thawed blastocyst ET compared to thawed ET at early cleavage embryo, and the higher perinatal parameters of born children after thawed ET. Embryo thawing induces a stress. Controlled stress is not necessarily detrimental, because it generates a phenomenon that is counteracted by several known biological responses aimed to repair mitochondrial damage of membrane and protein misfolding. The term for favorable biological responses to low exposures to stress is called hormesis.ConclusionsThis thesis will summarize the role of cryopreservation in the activation of a hormetic response, preserving the mitochondrial function, improving survival, and having an impact on the process of implantation, miscarriage, and the development of pregnancy.
Planetary Boundaries and Sustainability Indicators. A Survey of Corporate Reporting Boundaries
Authors: Antonini Carla , Larrinaga Carlos 
Published: April 2017

AbstractThe aim of this research is twofold: (a) to inquire into the methodological foundations of boundary setting for improved sustainability reporting and (b) to explore current corporate practice in this area, with a particular emphasis on environmental indicators. The paper contends that the boundaries of significant sustainability indicators should encompass all entities over which there is sustainability control, together with indirect impacts arising from activities across the supply chain, and not merely direct impacts caused by entities within boundaries based on financial control. The paper explores, through an empirical study of the sustainability reports disclosed by some of the top FT500 companies, how corporations are setting environmental boundaries in practice. Results show a lack of ambition in the practice of setting organizational and operational boundaries. Most reporting entities define organizational boundaries restricted to financial control, and most of the indirect environmental impacts sought remain undisclosed. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
National Museum of Qatar
Authors: Winterstetter Thomas , Toth Agatha , Sobek Werner , Baur Marco , Graser Konrad 
Published: April 2017

AbstractHerrn Univ.‐Prof. em. Dr.‐Ing. Herbert Schmidt zur Vollendung seines 80. Lebensjahres gewidmetIm Zuge des Ausbaus von Doha, der Hauptstadt von Katar, zu einem weltweiten Finanz‐, Kultur‐ und Tourismuszentrum entstand auf der Grundlage eines Entwurfs von Atelier Jean Nouvel (AJN) der Neubau des Nationalmuseums (National Museum of Qatar, NMoQ). Das unverwechselbare dreidimensionale Design und die Größe des Projekts stellten höchste Anforderungen an Planung und Installation des Haupttragwerks und der Gebäudehülle.
Hypoxia-Mediated Epigenetic Regulation of Stemness in Brain Tumor Cells
Authors: Prasad Pankaj , Mittal Shivani Arora , Chongtham Jonita , Mohanty Sujata , Srivastava Tapasya 
Published: April 2017

Abstract
Activation of pluripotency regulatory circuit is an important event in solid tumor progression and the hypoxic microenvironment is known to enhance the stemness feature of some cells. The distinct population of cancer stem cells (CSCs)/tumor initiating cells exist in a niche and augment invasion, metastasis, and drug resistance. Previously, studies have reported global hypomethylation and site-specific aberrant methylation in gliomas along with other epigenetic modifications as important contributors to genomic instability during glioma progression. Here, we have demonstrated the role of hypoxia-mediated epigenetic modifications in regulating expression of core pluripotency factors, OCT4 and NANOG, in glioma cells. We observe hypoxia-mediated induction of demethylases, ten-eleven-translocation (TET) 1 and 3, but not TET2 in our cell-line model. Immunoprecipitation studies reveal active demethylation and direct binding of TET1 and 3 at the Oct4 and Nanog regulatory regions. Tet1 and 3 silencing assays further confirmed induction of the pluripotency pathway involving Oct4, Nanog, and Stat3, by these paralogues, although with varying degrees. Knockdown of Tet1 and Tet3 inhibited the formation of neurospheres in hypoxic conditions. We observed independent roles of TET1 and TET3 in differentially regulating pluripotency and differentiation associated genes in hypoxia. Overall, this study demonstrates an active demethylation in hypoxia by TET1 and 3 as a mechanism of Oct4 and Nanog overexpression thus contributing to the formation of CSCs in gliomas.
Industrial use of HiPIMS and the hiP‐V hiPlus technology
Authors: Eichenhofer Gerhard , Fernandez Ivan , Wennberg Ambiörn 
Published: April 2017

AbstractIt has been demonstrated by several groups that HiPIMS is a state of the art tool for applying demanding coatings with superior film properties. The real industrial breakthrough for the HiPIMS‐technology, has not yet happened. On the other hand, the up till now available HiPIMS‐PS were mainly been up‐scaled “prototypes”, far away from industrial work horses. With the hiP‐V HiPIMS power system, a direct derivative of a robust power supply technology already in commercial use for public transportation systems, another milestone is set to make the HiPIMS technology go mainstream.HiPIMS is not a revolution that will make all other technologies obsolete, yet it is a very powerful complement. With a reliable, multi‐functional power supply and with a rapid arc‐handling, it could possibly be a start of a new era in thin film production. Just consider the possibility of etching and implantation to increase cleanliness and adhesion of the samples.Until now, most of the R&D work done in HiPIMS, has been dedicated to hard coatings and tool coatings. Here, HiPIMS is surely useful but not the expected technological breakthrough. For the future, the implementation of the new positive reverse pulse, the hiP‐V hiPlus HiPIMS technology, is opening a whole new field of possible applications for i.e. nonconductive substrates where no bias can be applied. Glass and plastics can be processed with remarkable results in hardness, enhanced film properties and additionally, it is achieved at lower substrate temperatures.It has been a slow start for HiPIMS, but the future looks bright.
“Numb‐Leg” in a CrossFit Athlete: A Case Presentation
Authors: Esser Stephan , Thurston Mckennan , Nalluri Krishna , Muzaurieta Aurelio 
Published: April 2017

AbstractParticipation in CrossFit athletics and Olympic‐style lifting by the general populace has rapidly increased in the last 10 years. Such athletic engagement poses unique, inadequately defined risks to the participant. We describe the case of a 36‐year‐old man who presented to an outpatient sports medicine clinic with 6 weeks of numbness and tingling in the lateral right proximal thigh. After thorough examination and electromyographic testing, he was found to have a lateral femoral cutaneous neuropathy caused by performing supine gluteal bridges with a weighted barbell resting across his anterior thighs. His case exemplifies the unique exercise demands and injury risks of CrossFit‐style exercise. Sports medicine providers should be familiar with both trends in sports/fitness participation and the associated unique risks that such sports pose, so as to adequately counsel patients on safety of participation and to correctly identify the cause of injury when evaluating patients in the clinical setting.Level of EvidenceV
Integrating Musculoskeletal Education and Patient Care at Medical Student−Run Free Clinics
Authors: McQuillan Thomas , Wilcox‐Fogel Nate , Kraus Emily , Ladd Amy , Fredericson Michael 
Published: April 2017

AbstractBackgroundStudent‐run free clinics (SRFCs) have emerged as an important educational component of United States (U.S.) medical schools. Despite the prevalence of musculoskeletal (MSK) problems presenting to SRFCs, students and clinics are often unprepared to diagnose and to treat common MSK complaints.ObjectiveWe sought to determine the scope of diagnosis and treatment at a medical student−run free clinic specializing in musculoskeletal care using physical medicine and rehabilitation (PM&R) residents. Secondary goals included reviewing student satisfaction and determining the appropriateness of the clinic in medical education.DesignRetrospective chart review, anonymous online survey.SettingPrimary care, free student clinic affiliated with tertiary academic medical center.ParticipantsA total of 20 medical student volunteers, 6 PM&R residents, and 91 community patients.MethodsWe established a musculoskeletal clinic as a specialty referral clinic for the 2 primary care SRFCs with institutional support from a partner medical school. We then reviewed clinical operations retrospectively using electronic medical records and student satisfaction based on an online survey.Main Outcome MeasurementsWe analyzed patient demographics and chief complaints, referrals provided, and medical services rendered. We also used a 5‐point Likert scale to assess student satisfaction.ResultsA monthly musculoskeletal referral clinic was established with the oversight of PM&R attendings and residents. The clinic received 91 referrals and managed 61 unique patients over a 2.5‐year study period. The most common presentations to the clinic involved knee pain (n = 17, 27.9%) and back pain (n = 16, 26.2%). Pro bono relationships with community and institutional partners enabled all patients to receive medical examinations, physical therapy visits, plain film radiographs, and insurance consultations free of charge. Student satisfaction with teaching and patient care was high, with 19 of 20 students reporting their experience as “good” or “excellent.”ConclusionsSRFCs represent an underused opportunity to enhance MSK education among medical students by treating a variety of common MSK complaints in an underserved population.Level of EvidenceNot applicable.
The Role of Magnetometry in Managing Arctic Archaeological Sites in the Face of Climate Change
Authors: Hodgetts Lisa M. , Eastaugh Edward J. H. 
Published: April 2017

ABSTRACTClimate change is impacting archaeological sites around the globe, and Arctic sites are among the most vulnerable because the region is experiencing particularly rapid change. In the face of this threat, archaeologists, heritage managers, and northern communities need to develop strategies for documenting and monitoring Arctic sites and prioritizing them for further investigation. Using three case studies from Banks Island in the western Canadian Arctic, we demonstrate how magnetometer survey could assist in this process, despite the region's poorly developed soils, widespread glacial tills, and periglacial geomorphology, which pose challenges for the technique. The case studies illustrate the utility of magnetometry in mapping both archaeological and permafrost features in the Arctic, allowing it to rapidly investigate site structure and assess the level of threat due to climate change.
The Disguises of the Mind: Recent Palestinian Memoirs
Authors: DeYoung Terri 
Published: April 2017

AbstractThis article examines developments in the memoir form in Palestinian literature over time, concentrating on the period since the Oslo Accords of 1993. It begins by briefly looking at new, general theoretical perspectives on the memoir form relevant to recognizing the importance of memoirs by Palestinians. A shift from viewing memoirs as purely the product of individuals to validating the notion ofcollectiverecollection occurs in the theoretical literature and can be documented in the Palestinian memoir. Similarly, attention to the idea of recollection asfluidand as aprocessenriches our understanding of what Palestinian memorists are trying to achieve. This section draws upon the work of such foundational figures as Maurice Halbwachs, Paul Ricoeur, Sidonie Smith, and Julia Watson. It also incorporates the insights of those who have focused more specifically on the Palestinian memoir form, such as Rashid Khalidi and Susan Slyomovics. These theoretical views are then tested through the examination of fourteen works using the memoir format, ranging from the time of the dissolution of the Palestinian Mandate (Sakkakini, Jabra, Boullata) to the beginning of the new millennium and the decade beyond (Darwish, Barghouti, Amiry and Karmi). The article shows that any literary history of the memoir form in modern times would be incomplete without recognizing and incorporating the Palestinian contribution to this increasingly popular literary genre.
Influence of Hegenshan–Heihe suture on evolution of late Mesozoic extensional structures in Wunite depression, Erlian Basin, Inner Mongolia, China
Authors: MIAO QUANYUN , QI JIAFU , WANG LISHUANG , ZHANG SHUAI , WEI XIULI 
Published: April 2017

AbstractWe integrate previous work on the Hegenshan–Heihe suture with our interpretation of geomagnetic anomaly and seismic reflection data to investigate the role of the Hegenshan–Heihe suture in the evolution of late Mesozoic extensional structures in the Wunite depression of the Erlian Basin. Sags in the Wunite depression present as NE50° trending in the western sector, N0°–NE30° trending in the central sector and NE45° trending in the eastern sector. Our results highlight the importance of the pre-existing Hegenshan–Heihe suture in the evolution of the late Mesozoic rift system and reveal the following details. (1) The NE50° extent sags in the western sector are controlled by the c. NE50°-trending suture. Moreover, the extensional deformation of the reactivated suture during Early Cretaceous time resulted in a further vertical and horizontal extension of major border faults. (2) The N0°–NE30° extent sags in the central sector are influenced by the c. NE75°-trending suture. The sinistral strike-slip component of the reactivated suture during Early Cretaceous time resulted in a strike rotation of major border faults from NEE-trending (following the suture) to NNE-trending. (3) Because of strike-slip deformation, which resulted from the deformation of the reactivated suture accrued in major border faults, light dip-slip deformation led to less vertical offset. (4) The NE45°-trending sags in the eastern sector are controlled by the c. NE45°-trending suture. Moreover, the extensional deformation of the reactivated suture during Early Cretaceous time facilitated a further vertical and horizontal prolongation of major border faults.
Discourse analysis of the 2013–2016 Arctic Circle Assembly programmes
Authors: Johannsdottir Lara , Cook David 
Published: April 2017

ABSTRACTThe Arctic Circle Assembly has established itself as a forum for stakeholders from all around the globe to discuss Arctic affairs. This includes discussion about the future of the Arctic, impacts of climate change on local inhabitants and indigenous peoples, the natural environment and wildlife, geopolitical issues, international treaties, research projects, business-related risks and opportunities, etc. At this international conference, the interests of stakeholders vary greatly. Some want to reap the economic and strategic benefits of melting glacial and sea ice, while others want to reduce the negative impacts of climate change. It is therefore important to analyse the conference discourse in order to understand the main emphases of stakeholders, and if some express their views more loudly than others. Through greater weight of voice in the Assembly and beyond, some stakeholders have more impact on the development of a region that is of economic, geopolitical and environmental importance, not only for the northern hemisphere but globally.
Who Wants Demanding Active Labour Market Policies? Public Attitudes towards Policies that put Pressure on the Unemployed
Authors: FOSSATI FLAVIA 
Published: April 2017

AbstractThe literature addressing attitudes about social policy and the welfare state has been telling us for decades that welfare interventions are supported by those individuals who benefit from a specific measure. The diffusion of ‘demanding’ active labour market policies (ALMPs), however, challenges this relationship. Using a novel dataset, I analyse which individual- and country-level factors explain public support for demanding ALMPs in five Western European countries. The results show that labour market risk and ideological orientation influence public attitudes towards these ALMPs. Thereby, unemployed individuals sympathising with the political right are more strongly opposed to demanding measures than employed individuals with the same political preferences. Moreover, aggregate support is found to be correlated with the country's ALMP legacy, varying from high levels in Germany and the UK to low levels in Denmark and France. The findings suggest that most ALMPs are in fact implemented despite the opposition of their beneficiaries.
Investigation of vitamin D status and its correlation with insulin resistance in a Chinese population
Authors: Han Bing , Wang Xiaojin , Wang Ningjian , Li Qin , Chen Yi , Zhu Chunfang , Chen Yingchao , Xia Fangzhen , Pu Xiaoqi , Cang Zhen , Zhu Chaoxia , Lu Meng , Meng Ying , Guo Hui , Chen Chi , Tu Weiping , Li Bin , Hu Ling , Wang Bingshun , Lu Yingli 
Published: April 2017

AbstractObjectiveAlthough many studies worldwide have focused on the relationship between vitamin D and insulin resistance, results remain controversial. Furthermore, concentrations of serum 25-hydroxyvitamin D (25(OH)D) in the Chinese population are unclear. We aimed to investigate vitamin D status and its correlation with insulin resistance among a Chinese adult population.DesignSerum 25(OH)D, fasting blood glucose, fasting insulin, glycated Hb (HbA1c) and other metabolic parameters were assessed. Neck circumference, waist circumference, hip circumference, weight and height were also measured. Lifestyle factors including smoking and drinking status were obtained. Diabetes mellitus was diagnosed by HbA1c according to the 2010 American Diabetes Association criteria.SettingEastern China.SubjectsOf 7200 residents included, 6597 individuals were ultimately analysed.ResultsWe enrolled 2813 males (mean age 52·7 (sd 13·5) years) and 3784 females (52·3 (sd 13·5) years); mean serum 25(OH)D concentration was 43·1 (sd 11·6) and 39·6 (sd 9·8) nmol/l, respectively. Additionally, 83·3 % of participants were 25(OH)D deficient. A significant difference in 25(OH)D was observed between males and females in winter and spring (P<0·001). Furthermore, 25(OH)D concentrations were inversely associated with the homeostasis model assessment of insulin resistance (HOMA-IR) in the overweight and pre-diabetic populations. After adjusting for several variables, 25(OH)D was significantly associated with HOMA-IR in winter. When 25(OH)D values were categorized into quartiles, HOMA-IR was significantly associated with decreasing 25(OH)D.ConclusionsThe majority of the Chinese population was vitamin D deficient and this deficiency was negatively associated with insulin resistance, particularly in the overweight and pre-diabetic populations. Moreover, these associations might be more evident in the winter.
Stability of a Bifunctional Cu-Based Core@Zeolite Shell Catalyst for Dimethyl Ether Synthesis Under Redox Conditions Studied by Environmental Transmission Electron Microscopy andIn SituX-Ray Ptychography
Authors: Baier Sina , Damsgaard Christian D. , Klumpp Michael , Reinhardt Juliane , Sheppard Thomas , Balogh Zoltan , Kasama Takeshi , Benzi Federico , Wagner Jakob B. , Schwieger Wilhelm , Schroer Christian G. , Grunwaldt Jan-Dierk 
Published: April 2017

AbstractWhen using bifunctional core@shell catalysts, the stability of both the shell and core–shell interface is crucial for catalytic applications. In the present study, we elucidate the stability of a CuO/ZnO/Al2O3@ZSM-5 core@shell material, used for one-stage synthesis of dimethyl ether from synthesis gas. The catalyst stability was studied in a hierarchical manner by complementary environmental transmission electron microscopy (ETEM), scanning electron microscopy (SEM) andin situhard X-ray ptychography with a specially designedin situcell. Both reductive activation and reoxidation were applied. The core–shell interface was found to be stable during reducing and oxidizing treatment at 250°C as observed by ETEM andin situX-ray ptychography, although strong changes occurred in the core on a 10 nm scale due to the reduction of copper oxide to metallic copper particles. At 350°C,in situX-ray ptychography indicated the occurrence of structural changes also on theµm scale, i.e. the core material and parts of the shell undergo restructuring. Nevertheless, the crucial core–shell interface required for full bifunctionality appeared to remain stable. This study demonstrates the potential of these correlativein situmicroscopy techniques for hierarchically designed catalysts.
Controlling the orbital angular momentum of high harmonic vortices
Authors: Kong Fanqi , Zhang Chunmei , Bouchard Frédéric , Li Zhengyan , Brown Graham G. , Ko Dong Hyuk , Hammond T. J. , Arissian Ladan , Boyd Robert W. , Karimi Ebrahim , Corkum P. B. 
Published: April 2017

AbstractOptical vortices, which carry orbital angular momentum (OAM), can be flexibly produced and measured with infrared and visible light. Their application is an important research topic for super-resolution imaging, optical communications and quantum optics. However, only a few methods can produce OAM beams in the extreme ultraviolet (XUV) or X-ray, and controlling the OAM on these beams remains challenging. Here we apply wave mixing to a tabletop high-harmonic source, as proposed in our previous work, and control the topological charge (OAM value) of XUV beams. Our technique enables us to produce first-order OAM beams with the smallest possible central intensity null at XUV wavelengths. This work opens a route for carrier-injected laser machining and lithography, which may reach nanometre or even angstrom resolution. Such a light source is also ideal for space communications, both in the classical and quantum regimes.