bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethnic Studies as a Site for Political Education: Critical Service Learning and the California Domestic Worker Bill of Rights
Authors: Mitchell Tania D. , Coll Kathleen M. 
Published: January 2017

ABSTRACTService learning in political science is driven by a commitment to expanding what is meant by civic education. Following this tradition, this article presents an example of a course informed by critical service learning centered in a grassroots social movement. Partnered with the California Domestic Workers Coalition and the National Domestic Workers Alliance, this course involved students in direct political engagement to explore cultural citizenship, the legislative process, and the possibilities and limitations of grassroots movements for social change. Challenging traditional notions of what counts as service and who counts as an expert, the example of this course speaks to the promise of service learning pedagogy as a strategy to connect students in meaningful ways to critical social issues and as a tool for political education.
Troubled Waters: Tracing Globalization and Waste in the Delaware River
Authors: Borowiak Craig , Funari Vicky , Ross Jesikah Maria , White Helen K. 
Published: January 2017

ABSTRACTIn spring 2014, an interdisciplinary media project titled “Troubled Waters: Tracing Waste in the Delaware River” was organized at Haverford College. This project brought together more than 50 students from four courses comprising introductory political science, chemistry, and documentary film students, as well as a community media artist and community partners. The aim was to explore the causes, impacts, and meanings of different types of waste that are polluting the Delaware River. Chemistry students collected samples to determine the presence of chemicals from various waste products, political science students traced the waste to globalized production processes, and documentary students explored diverse ways of representing the theme of waste on screen. This article describes the project and how it might serve as a pedagogical model for multicourse interdisciplinary collaboration and community engagement.
Developing Immersive Simulations: The Potential of Theater in Teaching and Learning in Political Studies
Authors: Dacombe Rod , Morrow Elizabeth A. 
Published: January 2017

ABSTRACTInnovative teachers of political science have frequently moved beyond the confines of conventional teaching formats to better engage students with the demands of the discipline. In particular, the use of simulations has been proposed as an alternative to passive, lecture-based techniques, and a growing literature examines their value and efficacy. This article contributes to the literature by describing the development of a simulation that draws on the principles of immersive theater in an attempt to maximize participation while encouraging students to think critically about political concepts and ideas.
Teach a Student to Fish? International Relations Scholars in the Classroom
Authors: Rathbun Nina Srinivasan , Rathbun Brian C. 
Published: January 2017

ABSTRACT
American higher-education institutions are under increasing pressure to prepare their students with practical skills for the workplace, and the social sciences—including political science—are not immune. Political figures have suggested—sometimes seconded by academics themselves—that research distracts academics from imparting practical skills to undergraduate students. Using a survey of international relations (IR) scholars, this article shows that this is not the case. Those who spend more time on research actually devote more time to policy-relevant research in their courses than more abstract and theoretical work, and they incorporate more contemporary issues. Research seems to encourage academics to teach their students to fish.
Optimizing outcomes in ADHD treatment: from clinical targets to novel delivery systems
Authors: Mattingly Gregory W. , Anderson Richard H. 
Published: January 2017

Our knowledge and understanding of the underlying neurobiology and symptomatic expression of ADHD has advanced dramatically over the past decade. Associated with these advances has been a similar explosion of new treatment options to individualize treatment for our patients.This article will:∙review strategies to measure ADHD symptoms and functional difficulties while seeking to achieve full symptomatic remission throughout the day∙summarize recent findings regarding the management and prioritization of ADHD and comorbid conditions and∙discuss the various pharmacologic treatment options with a focus on recently developed molecules and novel delivery systems
Palliative care during the final week of life of older people in nursing homes: A register-based study
Authors: Smedbäck Jonas , Öhlén Joakim , Årestedt Kristofer , Alvariza Anette , Fürst Carl-Johan , Håkanson Cecilia 
Published: January 2017

ABSTRACTObjective:Our aim was to explore the presence of symptoms, symptom relief, and other key aspects of palliative care during the final week of life among older people residing in nursing homes.Method:Our study employed data from the Swedish Palliative Care Register on all registered individuals aged 60 and older who had died in nursing homes during the years 2011 and 2012. Variables pertaining to monitoring and treatment of symptoms, end-of-life discussions, circumstances around the death, and the individual characteristics of deceased individuals were explored using descriptive statistics.Results:The most common underlying causes of death among the 49,172 deceased nursing home residents were circulatory diseases (42.2%) and dementia (22.7%). The most prevalent symptom was pain (58.7%), followed by rattles (42.4%), anxiety (33.0%), confusion (21.8%), shortness of breath (14.0%), and nausea (11.1%). Pain was the symptom with the highest degree of total relief (46.3%), whereas shortness of breath and confusion were totally relieved in 6.1 and 4.3% of all individuals, respectively. The use of valid instruments for symptom assessment was reported for pain in 12.3% and for other symptoms in 7.8% of subjects. The most prevalent individual prescriptions for injection PRN (pro re nata, according to circumstances) were for pain treatment (79.5%) and rattles (72.8%). End-of-life discussions were performed with 27.3% of all the deceased individuals and with 53.9% of their relatives. Of all individuals, 82.1% had someone present at death, and 15.8% died alone. Of all the nursing home resident deaths recorded, 45.3% died in their preferred place.Significance of results:There were large variations in degree of relief from different symptoms during the final week of life. Pain was the most prevalent symptom, and it was also the symptom with the highest proportion of total/partial relief. Other symptoms were less prevalent but also less well-relieved. Our results indicate a need for improvement of palliative care in nursing home settings, focusing on management of distressing symptoms and promotion of end-of-life discussions.
Assessment of genetic diversity of Mithun (Bos frontalis) population in Bhutan using microsatellite DNA markers
Authors: Tenzin Sangay , Dorji Jigme , Dorji Tashi , Kawamoto Yoshi 
Published: January 2017

SummaryGenetic diversity of Mithun population in Bhutan was studied using 14 microsatellite markers. Two sets of two-step polymerase chain reactions were performed with multiplex and individual markers for genotyping 105 hair samples collected from Arong in Samdrupjongkhar (AS, 36) and Wangdigang in Zhemgang (WZ, 69). Fifty-three alleles were detected with average of 3.89 alleles and polymorphism information content of 0.44 ± 0.03 per locus. A low level of genetic variability within population was present with observed heterozygosity at 0.50 ± 0.06 and expected heterozygosity at 0.48 ± 0.06. Analysis of molecular variance attributed 58 percent of total variation to within the individuals. MeanFISandFITwere −0.056 and 0.005 respectively, indicated low level of population differentiation and limited out-breeding. The normal L-shaped distribution of allelic frequencies without any mode-shift revealed the absence of recent genetic bottleneck in Mithun populations. Therefore to manage inbreeding in the small Mithun population of Bhutan, periodic assessment of inbreeding levels and exchange of animals between farms is recommended to reduce frequency of introduction of animals from India.
Assessment of the genetic variability using pedigree analysis of the Sahiwal breed in Kenya
Authors: Mwangi S. , Muasya T.K. , Ilatsia E.D. , Kahi A.K. 
Published: January 2017

Summary
Pedigree analysis using genealogical information of 18 315 animals born between 1949 and 2008 was done to quantify genetic variability of the Sahiwal population in Kenya. Generation intervals for sire pathways were longer than dam pathways and increased over year periods, from about 4–16 years. The later was due to use of old bulls for breeding in the last 2 year groups and cessation of progeny testing in the year 2000. Average inbreeding level in last year period studied was 1.2 percent. Genetic variability of the population as assessed based on gene origin statistics decreased over the years. The ratio of effective number of founders to founders of 0.06 showed unequal contribution of founders to the reference population. However, since the founding population, ancestors contributed equally as shown by the ratio of f
e/f
a of 0.94, which could also be due to lack of effective selection in this population. The ratio of f
g/f
a of 0.63 indicated genetic loss of genetic variability occurred through genetic drift in the Kenyan Sahiwal population. The small number of ancestors (16) that accounted for 50 percent of the total variation in the reference population suggested overuse of a small number of some animals as parents over generations. The smaller ratio of f
g/f
e compared with f
a/f
e also confirms loss of genetic variability in the population by genetic drift than bottlenecks. Therefore the breeding strategy for the Sahiwal population in Kenya should incorporate tools that balance rate of genetic gain and the future rate of inbreeding.
Reproductive parameters of some native bovine breeds: Sanmartinero and Casanareño
Authors: Moncaleano-Vega J. , Parra Molina R. , Peña Joya M.A. , Parra Arango J.L. , Góngora A. 
Published: January 2017

ResumenEn bovinos, la reducción de la eficiencia reproductiva de los sistemas de producción de carne y doble propósito se atribuye a factores nutricionales, sanitarios, climáticos y en última instancia a características genéticas de los animales. Sin embargo, en condiciones de trópico cálido húmedo, variaciones genéticas entre razas podrían reducir la edad al primer parto, el intervalo entre partos y aumentar la vida útil de las vacas. Las razas Sanmartinero y Casanareño podrían mejorar los sistemas de producción bovina debido al aporte de variantes genéticas que emergieron en el proceso de adaptación a las duras condiciones de la Orinoquía Colombiana. Actualmente, los genes con función biológica conocida se usan como marcadores moleculares para estimar parámetros de diversidad genética pecuaria facilitando la identificación y ubicación dentro del genoma de regiones que codifican o regulan la expresión de rasgos de interés económico. En ganado criollo colombiano Romosinuano se han identificado genes candidatos del eje Hormona de crecimiento/Factor de crecimiento similar a la insulina que se asocian positivamente con edad al primer parto, intervalo entre partos, longevidad y protección del embrión al estrés calórico. No obstante en las razas criollas Sanmartinero y Casanareño reconocidas empíricamente por estas características, no han sido sometidas a dichos análisis de genes candidatos que permitan promover un valor agregado a los animales. El objetivo de esta revisión es documentar algunos parámetros reproductivos y genéticos de las razas criollas Sanmartinero y Casanareño que soportan la necesidad de desarrollar estudios moleculares y justificar su uso en los sistemas de producción de carne y doble propósito de la Orinoquía colombiana.
Impacts of climate variability on livestock population dynamics and breed distribution patterns in selected districts of Western Amhara, Ethiopia
Authors: Alemayehu Kefyalew , Getu Addis 
Published: January 2017

Summary
Climate change affects the livestock populations. As temperature increases, the rainfall distribution patterns shifts. These indirectly change the ecosystems like changes in crop yield, alter the distribution of animal diseases, geographically restriction of rare breed populations and increased competition for resources. Therefore, the objective of the study was to quantify impacts of climate variability on livestock population dynamics and breed distribution patterns. The study was conducted in Gondar Zuria, Farta and Bahir Dar Zuria districts. The sites were selected based on agro-ecology and livestock distribution potential. Data were collected through desk reviews of different documents and studies, focused group discussions, key informants interviews and different projection models. The results revealed that 70 percent of respondents believed that the trends of livestock breed distribution varied from year to year and from agro-ecology to agro-ecology. The number of cattle and equines are decreasing from year to year due to climate variability. Particularly, the crossbred cattle population decreased in 1998, 2002 and 2008 due to shortage of rainfall, increments of temperature and feed shortage. A correlation analysis was used to quantify impacts of temperature and rainfall on livestock population dynamics and breed distribution. The analyses revealed that sheep (r = −0.535, P &lt; 0.05) and cattle (r = −0. 512, P &lt; 0.05) were negatively affected by climate variability. Whereas goats were having positive relationship (r = 0.345, P &lt; 0.001). As the average maximum temperature steadily increases, the population dynamics of ruminant livestock fluctuated after the year 1996. About 92.2, 78 and 83.3 percent respondents in Farta, Gondar Zuria and Bahir Dar Zuria districts, respectively, stated that there is a fluctuation in amount of rainfall distribution during the main rainy seasons. About 84.5 percent of respondent of the three districts also believed that climate change made variation in rainfall distribution. About 52 percent of the respondents also suggested that if livestock is to be protected from climate change and related effects, changing the farming system with appropriate breed is important and can be achieved with the zero-grazing system. The farmers also recommended with stocking climate change adaptive and productive breeds. In conclusion, climate variability affected livestock population dynamics and breed distribution pattern negatively.
Egg production and certain behavioural characteristics and mortality pattern of indigenous chicken of India
Authors: Kumar P.G. , Churchil R.R. , Jalaludeen A. , Narayanankutty K. , Peethambaran P.A. , Praveena P.E. , Chacko B. , Ajithbabu B. 
Published: January 2017

Summary
A survey to document the behaviour characteristics and mortality pattern of indigenous chicken of Kerala and a field egg recording study to record egg production characteristics of these birds were conducted. Flight distance and height was 13.29 and 3.97 m, respectively. The territory radius of cocks was 121.15 m. The chick survivability at 4 weeks of age was 64.98 percent. The day-old and 8th week body weights were 28.83 and 347.24 g, respectively. The 20th and 40th week body weight of males were 1,428.42 and 1,936.67 g and that of females were 1,114.04 and 1,445.63 g, respectively. The mortality up to 72 weeks was 69.38 percent and major cause of mortality during chick, grower and layer stage were mongoose (44.63 percent), wolf (24.29 percent) and diseases (52.18 percent) respectively. The fertility was 71.22 percent and hatchability on total and fertile egg set were 62.26 and 87.42 percent, respectively. There were 2.13 clutches in a laying cycle with inter-clutch intervals of 1.11 days. The average clutch size and number of eggs per cycle were 7.27 and 14.32, respectively. The egg number up to 72 weeks on hen-day and hen-housed basis was 116.81 and 85.84, respectively and the eggs were laid in 7.7 cycles. The age at first egg and average age at sexual maturity were 155 and 199.26 days, respectively. The egg weight at 28, 40 and 72 weeks of age was 37.80, 40.74 and 43.31 g, respectively, and egg mass per bird was 4,659.04 g. The broodiness and incubation pause were 26.03 and 121.75 days, respectively.
Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells
Authors: Narayanan Nithya , Wang Zhihao , Li Ling , Yang Yanzhong 
Published: January 2017

AbstractThe Tudor domain-containing proteins are characterized by their specific interactions with methylated protein motifs, including methyl-arginines and methyl-lysines. The Tudor domain-containing protein 3 (TDRD3) is one of the major methyl-arginine effector molecules that recognizes methylated arginine residues on histones and the C-terminal domain of RNA polymerase II, and activates transcription. However, majority of the cellular TDRD3 localizes to the cytoplasm and its functions there are still elusive. Here, we have identified ubiquitin-specific protease 9 X-linked (USP9X) as a TDRD3-interacting protein by GST (glutathione S-transferase) pull-down and co-immunoprecipitation. Detailed characterization suggests that the interaction between TDRD3 and USP9X is mediated through the Tudor domain of TDRD3 and the arginine methylation of USP9X. This interaction plays a critical role in TDRD3 protein stability, as knockdown of USP9X expression leads to increased TDRD3 ubiquitination. We also found that USP9X co-localizes with TDRD3 in cytoplasmic stress granules and this localization is diminished in Tdrd3-null mouse embryonic fibroblast cells, suggesting that TDRD3 is essential for USP9X stress granule localization. Furthermore, we found that one of the USP9X de-ubiquitination targets, myeloid cell leukemia protein 1, is regulated by TDRD3, indicating that TDRD3 potentially regulates USP9X de-ubiquitinase activity. Finally, we show that knockdown of TDRD3 expression sensitizes breast cancer cells to chemotherapeutic drug-induced apoptosis, likely due to its regulation of USP9X. This study provides a novel candidate strategy for targeting apoptosis pathways in cancer therapy.
The Pseudomonas putida T6SS is a plant warden against phytopathogens
Authors: Bernal Patricia , Allsopp Luke P , Filloux Alain , Llamas María A 
Published: January 2017

Abstract
Bacterial type VI secretion systems (T6SSs) are molecular weapons designed to deliver toxic effectors into prey cells. These nanomachines have an important role in inter-bacterial competition and provide advantages to T6SS active strains in polymicrobial environments. Here we analyze the genome of the biocontrol agent Pseudomonas putida KT2440 and identify three T6SS gene clusters (K1-, K2- and K3-T6SS). Besides, 10 T6SS effector–immunity pairs were found, including putative nucleases and pore-forming colicins. We show that the K1-T6SS is a potent antibacterial device, which secretes a toxic Rhs-type effector Tke2. Remarkably, P. putida eradicates a broad range of bacteria in a K1-T6SS-dependent manner, including resilient phytopathogens, which demonstrates that the T6SS is instrumental to empower P. putida to fight against competitors. Furthermore, we observed a drastically reduced necrosis on the leaves of Nicotiana benthamiana during co-infection with P. putida and Xanthomonas campestris. Such protection is dependent on the activity of the P. putida T6SS. Many routes have been explored to develop biocontrol agents capable of manipulating the microbial composition of the rhizosphere and phyllosphere. Here we unveil a novel mechanism for plant biocontrol, which needs to be considered for the selection of plant wardens whose mission is to prevent phytopathogen infections.
Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics
Authors: Lopez-Siles Mireia , Duncan Sylvia H , Garcia-Gil L Jesús , Martinez-Medina Margarita 
Published: January 2017

Abstract
There is an increasing interest in Faecalibacterium prausnitzii, one of the most abundant bacterial species found in the gut, given its potentially important role in promoting gut health. Although some studies have phenotypically characterized strains of this species, it remains a challenge to determine which factors have a key role in maintaining the abundance of this bacterium in the gut. Besides, phylogenetic analysis has shown that at least two different F. prausnitzii phylogroups can be found within this species and their distribution is different between healthy subjects and patients with gut disorders. It also remains unknown whether or not there are other phylogroups within this species, and also if other Faecalibacterium species exist. Finally, many studies have shown that F. prausnitzii abundance is reduced in different intestinal disorders. It has been proposed that F. prausnitzii monitoring may therefore serve as biomarker to assist in gut diseases diagnostics. In this mini-review, we aim to serve as an overview of F. prausnitzii phylogeny, ecophysiology and diversity. In addition, strategies to modulate the abundance of F. prausnitzii in the gut as well as its application as a biomarker for diagnostics and prognostics of gut diseases are discussed. This species may be a useful potential biomarker to assist in ulcerative colitis and Crohn’s disease discrimination.
Endemicity of the cosmopolitan mesophilic chemolithoautotroph Sulfurimonas at deep-sea hydrothermal vents
Authors: Mino Sayaka , Nakagawa Satoshi , Makita Hiroko , Toki Tomohiro , Miyazaki Junichi , Sievert Stefan M , Polz Martin F , Inagaki Fumio , Godfroy Anne , Kato Shingo , Watanabe Hiromi , Nunoura Takuro , Nakamura Koichi , Imachi Hiroyuki , Watsuji Tomo-o , Kojima Shigeaki , Takai Ken , Sawabe Tomoo 
Published: January 2017

Abstract
Rich animal and microbial communities have been found at deep-sea hydrothermal vents. Although the biogeography of vent macrofauna is well understood, the corresponding knowledge about vent microbial biogeography is lacking. Here, we apply the multilocus sequence analysis (MLSA) to assess the genetic variation of 109 Sulfurimonas strains with ⩾98% 16S rRNA gene sequence similarity, which were isolated from four different geographical regions (Okinawa Trough (OT), Mariana Volcanic Arc and Trough (MVAT), Central Indian Ridge (CIR) and Mid-Atlantic Ridge (MAR)). Sequence typing based on 11 protein-coding genes revealed high genetic variation, including some allele types that are widespread within regions, resulting in 102 nucleotide sequence types (STs). This genetic variation was predominantly due to mutation rather than recombination. Phylogenetic analysis of the 11 concatenated genes showed a clear geographical isolation corresponding to the hydrothermal regions they originated from, suggesting limited dispersal. Genetic differentiation among Sulfurimonas populations was primarily influenced by geographical distance rather than gas composition of vent fluid or habitat, although in situ environmental conditions of each microhabitat could not be examined. Nevertheless, Sulfurimonas may possess a higher dispersal capability compared with deep-sea hydrothermal vent thermophiles. This is the first report on MLSA of deep-sea hydrothermal vent Epsilonproteobacteria, which is indicative of allopatric speciation.