bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric spinal cord astrocytomas: a retrospective study of 348 patients from the SEER database
Authors: Luksik Andrew S. , Garzon-Muvdi Tomas , Yang Wuyang , Huang Judy , Jallo George I. 
Published: March 2017

OBJECTIVEIntramedullary spinal cord tumors comprise 1%–10% of all childhood central nervous system neoplasms, with astrocytomas representing the most common subtype. Due to their rarity and poor prognosis, large population-based studies are needed to assess the epidemiology and survival risk factors associated with these tumors in the hope of improving outcome. The authors undertook this retrospective study to explore factors that may influence survival in pediatric patients with spinal cord astrocytomas.METHODSUtilizing the Surveillance, Epidemiology, and End Results (SEER) database, a prospective cancer registry, the authors retrospectively assessed survival in histologically confirmed, primary spinal cord astrocytomas in patients 21 years of age and younger. Survival was described with Kaplan-Meyer curves, and a multivariate regression analysis was used to assess the association of several variables with survival while controlling for confounding variables.RESULTSThis analysis of 348 cases showed that age (hazard ratio [HR] 1.05, 95% CI 1.01–1.09, p = 0.017), nonwhite race (HR 1.74, 95% CI 1.11–2.74, p = 0.014), high-grade tumor status (HR 14.67, 95% CI 6.69–32.14, p < 0.001), distant or invasive extension of the tumor (HR 2.37, 95% CI 1.02–5.49, p = 0.046), and radiation therapy (HR 3.74, 95% CI 2.18–6.41, p < 0.001) were associated with decreased survival. Partial resection (HR 0.37, 95% CI 0.16–0.83, p = 0.017) and gross-total resection (HR 0.39, 95% CI 0.16–0.95, p = 0.039) were associated with improved survival.CONCLUSIONSYounger age appears to be protective, while high-grade tumors have a much worse prognosis. Early diagnosis and access to surgery appears necessary for improving outcomes, while radiation therapy has an unclear role. There is still much to learn about this disease in the hope of curing children with the misfortune of having one of these rare tumors.
User embracement in practices care in psychosocial care centers the perspective of local managers
Authors: Cardoso da Silva Soares Andreza Kelly , Ximenes Guimarães José Maria , Feitosa de Araújo Aretha , Carneiro Cleide , Pereira Morais Ana Patrícia , Carneiro Aguiar Claudine , Saboia Paz Leonardo , Da Costa Marcélid Berto , Sousa Maria do Socorro , De Araújo Gomes Maria Elidiana , Fonseca Fernando Luiz Affonso , Miessa Ruiz Erasmo , Bezerra de Oliveira Maryldes Lucena 
Published: March 2017

Introduction: Psychosocial care centres (CAPS), strategic IN articulation of psychosocial care network and health system gateway, propose to the reorganization of health practices, by adopting a new ethic of care, based on respect to the singularity of the subjects and in the reception to the health needs of the users. Reception is a device for transforming practices and humanizing health care.
Objective: To analyse the operation of the host users of CAPS from the perspective of local coordinators in Fortaleza, Ceará, Brazil.
Method: Qualitative research with case study design, performed with CAPS coordinators of the city of Fortaleza, Ceará, Brazil. Data were collected through semi-structured interviews and observation, being submitted to the analysis of thematic content.
Results: The host constituted innovative device in mental health practices, as triggered the construction of new ways of dealing with the subject in psychological distress, by incorporating technologies such as qualified listening, building autonomy, with attention focused on the user. Provided a reorientation of work and service processes, requesting the articulation for network care. In addition, it was configured as a strategy for humanization in the CAPS. Was presented, however, operational difficulties related to the environment and to the effectiveness of the network of attention.
Final considerations: The host device configured for reorienting health practices, enhancing the consolidation of psychosocial care model, with humanization and increased solvability. However, challenges remain to be overcome, related to the environment and to the effectiveness of the network of care.
Nursing Care Systematization: A Study At A Teaching Hospital
Authors: Macêdo Louise Passos Vigolvino , Bezerra Alyne Fernandes , De Almeida Aran Rolim Mendes , Dantas Thayana Rose de Araújo , Veras Rafaella Felix Serafim , Falcão Renata Maia de Medeiros , Rodrigues Mayara Muniz Peixoto , Oliveira Jacira Dos Santos , Freire Maria Eliane Moreira , Vasconcelos Josilene De Melo Buriti 
Published: March 2017

Objective: Investigate the understanding of nurses who work at a teaching hospital, in relation to NCS and the nursing process; ascertain facilities/difficulties related to the applicability of the nursing process in that service; and verify the opinions of those professionals for the improvement and/or effectiveness of the nursing process at the hospitalization units of the hospital.
Method: Exploratory, descriptive study, with a qualitative approach. The sample consisted of 42 nurses who answered a questionnaire. The empirical material was analyzed and categorized based on the content analysis technique and discussed in the light of the literature.
Results: From the participants' discourses, two categories of analysis emerged: 1) understanding of NCS as a tool to organize the Nursing work process and improve the quality of care; and 2) applicability of the nursing process at the various hospitalization units of the institution.
Conclusion: The implementation and applicability of that method depend on not only the knowledge and motivation of the nursing professionals, but also on a strategic planning involving management and staff, from the recognition of their importance in order to obtain adherence and effective operationalization in practice.
Descriptors: Nursing; Nursing Process; Professional Practice.
Angiographic diagnosis of Meckel's diverticulum in an adult patient with negative scintigraphy
Authors: Kovacs Mark , Botstein Jonathan , Braverman Stuart 
Published: March 2017

A Meckel's diverticulum was diagnosed by mesenteric angiography in a 34 year-old patient who presented with hematochezia and dropping hemoglobin. The case demonstrates the challenges often encountered in workup of occult gastrointestinal (GI) bleeding, and shows that angiographic diagnosis of Meckel's diverticulum is possible, even in the absence of angiographic evidence of active extravasation. Our patient had a previous non-diagnostic workup including upper and lower endoscopy, videocapsulography, and Technetium-99m pertechnetate (Tc-99m) scintigraphy. Visceral angiogram demonstrated the presence of a persistent vitelline artery, diagnostic of Meckel's diverticulum. While no active extravasation was seen at the time of the angiogram, operative specimen demonstrated a Meckel's diverticulum with ectopic gastric mucosa and intraluminal hemorrhage.
Des cinémathèques au patrimoine cinématographique. Tendances du questionnement historiographique français
Authors: Louis Stéphanie-Emmanuelle 
Published: March 2017

Les cinémathèques s’étant peu à peu imposées comme des musées du cinéma, la problématique patrimoniale s’est développée concomitamment à l’écriture de leur histoire. Quels en furent les enjeux de développement, les facteurs de mutation, et quelles perspectives se dessinent-elles à l’heure actuelle ? Au-delà d’une tendance ancienne à écrire l’histoire depuis l’intérieur des organismes concernés, la transformation du questionnement s’est produite à la faveur de facteurs conjugués : la quête de légitimité d’acteurs du patrimoine réfléchissant à leurs pratiques ; l’appropriation du sujet par une génération d’auteurs plus distante des faits évoqués ; la nécessité de rationaliser la politique de ce secteur cinématographique parallèlement à un tournant culturel de l’historiographie du cinéma.
Actua 1, « film perdu » retrouvé de la filmographie de Philippe Garrel et de l’histoire du cinéma de Mai 68
Authors: Vergé Émilie 
Published: March 2017

Cet article présente le film collectif Actua 1, « actualités révolutionnaires » de Mai 68, réputé perdu et retrouvé en 2014 aux Archives Françaises du Film où il attendait dûment étiqueté. Un film en noir et blanc et 35mm tourné pendant les émeutes de 1968 à Paris que Garrel avait reconstitué in absentia dans les Amants réguliers en 2004 en une sorte d’auto-remake. En effet, bien que le collectif comportât Philippe Garrel, Jean-Luc Godard, Serge Bard et Patrick Deval, Actua 1 se révèle se rattacher avant tout à l’esthétique de Garrel et participer à la pensée situationniste critique du « cinéma-spectacle ».
Somatosensory Discrimination Intervention Improves Body Position Sense and Motor Performance in Children With Hemiplegic Cerebral Palsy
Authors: McLean Belinda , Taylor Susan , Blair Eve , Valentine Jane , Carey Leeanne , Elliott Catherine 
Published: March 2017

Abstract
OBJECTIVE. This study examined the use of the adult neuroscience-based Sense© intervention with children with hemiplegic cerebral palsy (HCP) to improve upper-limb somatosensory discrimination, motor function, and goal performance.
METHOD. Seventeen children with HCP (9 boys, 8 girls; mean age = 10.2 yr) participated in this pilot matched-pairs trial with random allocation and 6-mo follow-up (intervention, n = 7; control, n = 10). The intervention group received Sense training 3×/wk for 6 wk (18 hr). Outcome measures included Goal Attainment Scaling, Sense_assess© Kids, and the Assisting Hand Assessment.
RESULTS. The intervention group improved in goal performance, proprioception, and bimanual hand use and maintained improvement at 6-mo follow-up. The control group improved in occupational performance by 6-mo follow-up.
CONCLUSION. This study established the feasibility of using the Sense intervention in a pediatric setting and adds preliminary evidence to suggest that improving somatosensory function can improve motor function and goal performance among children with HCP.
Plasmapheresis, Intravenous Immunoglobulins, and Autologous Serum Eyedrops in the Acute Eye Complications of Toxic Epidermal Necrolysis
Authors: Pinna Antonio , Nuvoli Eleonora , Blasetti Francesco , Posadinu Maria Alma , Boscia Francesco 
Published: March 2017

Purpose Toxic epidermal necrolysis (TEN) is a rare, life-threatening, drug-induced, mucocutaneous disease, which can severely affect the ocular surface. The purpose of this study was to investigate the efficacy of plasmapheresis, human IV immunoglobulins (IVIg), and autologous serum (AS) eyedrops in the treatment of the severe acute ocular complications of TEN. Methods A retrospective chart review of all patients admitted to the Burn Unit, Azienda Ospedaliero-Universitaria-Sassari, Sassari, Italy, from 2009 to 2015, identified 9 patients (2 men, 7 women; mean age 63.8 ± 24.7 years) with TEN. Bilateral, acute ocular surface complications were observed in 7 (78%) patients; 3 showed catarrhal conjunctivitis, whereas 4 had severe pseudomembranous conjunctivitis and corneal ulcers. Results All patients with TEN were immediately treated with plasmapheresis and human IVIg, which produced a marked improvement in the patients’ general condition. In the 3 with catarrhal conjunctivitis, preservative-free artificial tears and topical antibiotics were beneficial. In the 4 with severe pseudomembranous conjunctivitis and corneal ulcers, treatment with AS eyedrops resulted in corneal and conjunctival epithelium healing over 3-6 weeks. After a minimum follow-up of at least 12 months, there were minimal/mild residual signs and symptoms of dry eye. Conclusions Plasmapheresis and IVIg may be life-saving and contribute to reduce ocular surface inflammation in TEN. Autologous serum eyedrops, prepared after plasmapheresis completion and IVIg infusion, may be helpful in the management of the severe acute ocular complications of TEN.
Co-Microencapsulation of BMSCs and Mouse Pancreatic (3 Cells for Improving the Efficacy of Type I Diabetes Therapy
Authors: Long Ruimin , Liu Yuangang , Wang Shibin , Ye Li , He Peng 
Published: March 2017

Introduction To overcome the shortcomings of pancreas transplantation and insulin injection treatment for type I diabetes, biocompatible materials were used to prepare alginate-chitosan-alginate microcapsules that co-encapsulated bone marrow mesenchymal stem cells and mouse pancreatic β cells to treat diabetic mice. Methods Blank alginate-chitosan-alginate (ACA) microcapsules and co-microencapsulated cells were prepared using a high-voltage electrostatic method and then characterized using an inverted microscope. Cell viability was evaluated using AO/EB staining. ELISA kit was used to detect insulin secretion. Peri-orbital blood samples were obtained from the mice for blood glucose determination every week for one month. Results After 28 days of in vitro culture, the secretion of insulin following co-microencapsulation was higher than that observed for microencapsulated beta-TC-6 cells alone. On the 28th day after transplantation, the blood glucose level was 6.86 mmol/L in the microencapsulated beta-TC-6 group. On the 14th day, the blood glucose level was 6.80 mmol/L in the co-microencapsulated BMSC/beta-TC-6 group, which was close to the normal blood glucose level of healthy mice. These results indicated that the efficacy in reducing blood glucose was better in the co-microencapsulated BMSC/beta-TC-6 group. Conclusions This primary study indicated that combining microencapsulation technology and co-culture of stem cells and somatic cells shows promise for the treatment of type I diabetes mellitus.
Optimizing the Fluidized Bed Bioreactor as an External Bioartificial Liver
Authors: Figaro Sarah , Pereira Ulysse , Rada Hiram , Semenzato Nicolas , Pouchoulin Dominique , Paullier Patrick , Dufresne Murielle , Legallais Cécile 
Published: March 2017

Background Our team previously designed and validated a new bioartificial liver (BAL) called Suppliver based on a Prismaflex™ device, including fluidized bed bioreactors hosting alginate-encapsulated hepatocytes. To ensure correct fluidization within the bioreactor, the beads need to become heavier with the addition of inert glass microspheres. Methods In this study, we assessed the impact of this additional component on the bead production process, bed fluidization, mass transfer and the mechanical properties of the beads, as well as cell viability and basic metabolic function. Results A concentration of 20 mg (1% v/v) of microspheres for 15–20 million cells per milliliter of alginate solution appears to be the best configuration. The filling ratio for the beads in the bioreactors can reach 60%. Four 250-mL bioreactors represent approximately 15% of the hepatocytes in a liver, which is a reasonable target for extracorporeal liver supply. Conclusions Increasing bead density clearly maintained the performances of the fluidized bed with plasma of different compositions, without any risk of release out of the bioreactor. A 1% (v/v)-concentration of microspheres in alginate solution did not result in any alteration of the mechanical or biological behavior. This concentration can thus be applied to the production of large-scale encapsulated biomass for further use of the Suppliver setup in human scale preclinical studies.
Transformation of the peripheral intravenous catheter placement experience in pediatrics
Authors: Kelly Steven , Russell Jean , Devgon Pitamber , Rosen Paul 
Published: March 2017

Background “Needle pokes” are the most frequent cause of pain encountered by pediatric patients in the hospital setting. Poor control of pain during needle pokes leads to short- and long-term adverse outcomes for both patients and hospitals. J-Tips are a needle-free injection system that use pressurized gas to inject lidocaine in a fine stream of fluid that penetrates the skin. This study undertook an evaluation of their effectiveness at decreasing the pain of the needle poke that takes place with IV insertion. Methods Participation was limited to patients between the ages of 3 and 16 who received an IV during a 3-week period at an academic pediatric hospital. Furthermore, patients requiring more than one attempt to place the IV were not included. Participants were recruited within 24 hours after having received their IV. The 10-point, Wong-Baker Faces Pain Rating Scale was the tool used to collect pain scores. Patients were recruited to the study by convenience sampling. Results Pain scores were collected from 85 patients. There were 41 patients who received needle-free injected lidocaine prior to IV insertion. There were 44 patients who received an IV without previous lidocaine injection. Mean pain scores for the two groups were 2.45 for the patients who received the needle-free injected lidocaine and 5.8 for the patients who did not (p value <0.001). Conclusions Results were consistent with the hypothesis that needle-free injection of lidocaine is an effective therapy for the management of pain in children between the ages of 3-16 years who receive an IV.
Gadolinium Contrast Agents - Are they Really Safe?
Authors: Malikova Hana , Holesta Michal 
Published: March 2017

Gadolinium-based contrast agents (GBCA) are used worldwide for enhanced MRI examinations, including heart and vessels. Gadolinium is a highly toxic heavy metal. If used in GBCA it must be tightly bound to ligands. The configuration of ligands influences the stability of the GBCA and two types of chelates have been used. Macrocyclic chelates offer better protection and binding of gadolinium ion than linear chelates with a flexible open chain - gadolinium could be more easily released from the latter ones. GBCAs are excreted from the body mostly by the kidneys, which is of importance in chronic kidney disease. Two states are related to gadolinium: nephrogenic systemic fibrosis (NSF) and gadolinium body storage. NSF is a severe and debilitating disease, directly connected to gadolinium toxicity, proven after the use of linear chelates. Due to strict recommendations of radiology societies, NSF was practically eradicated. Gadolinium deposition was observed especially in bones and in some brain areas: in dentate nucleus and in globus pallidus, even years after the GBCA administration. The form of the storage (chelated or free), as well as their clinical impact, are not clear, but first observations of “gadolinium deposition disease” have been reported.
The Significance of Lymphovascular Invasion of the Spermatic Cord in the Absence of Cord Soft Tissue Invasion
Authors: McCleskey Brandi C. , Epstein Jonathan I. , Albany Constantine , Hashemi-Sadraei Neda , Idrees Muhammad T. , Jorns Julie M. , Lu David Y. , Matoso Andres , Rais-Bahrami Soroush , Schwartz Lauren E. , Ulbright Thomas M. , Gordetsky Jennifer 
Published: March 2017

Context.—
Testicular germ cell tumors with lymphovascular invasion (LVI) are staged pT2, and those with spermatic cord involvement are staged pT3.

Objective.—
To study the clinical significance of LVI within the spermatic cord without direct involvement of the cord soft tissues.

Design.—
A retrospective, multi-institutional review was performed on testicular GCTs with spermatic cord LVI in the absence of cord soft tissue invasion.

Results.—
Forty-four germ cell tumors had LVI in the spermatic cord without soft tissue invasion; 37 of 44 patients (84%) had nonseminomatous germ cell tumors (NSGCT), and 7 (16%) had pure seminomas. Patients with NSGCTs and spermatic cord LVI had worse clinical outcomes compared with patients with pure seminoma and spermatic cord LVI (P = .008). We then compared patients with NSGCTs and spermatic cord LVI (n = 37) to patients with NSGCTs and LVI limited to the testis (n = 32). A significantly greater percentage of patients with LVI in the spermatic cord presented with advanced clinical stage (76% versus 50%; P = .01). There was no statistically significant difference in disease recurrence/progression or death between patients with spermatic cord LVI and patients with LVI limited to the testis (P = .40; P = .50). There was no significant difference in the presence of embryonal dominant histology (P = .30) or rete testis invasion (P = .50) between the 2 groups. More hilar soft tissue invasion was seen in patients with LVI present in the spermatic cord (P = .004).

Conclusions.—
In patients with NSGCTs, LVI in the spermatic cord, without soft tissue invasion, is associated with worse clinical stage at presentation compared with patients with LVI confined to the testis.
Control Variates
Authors: Lemieux Christiane 
Published: March 2017

AbstractMonte Carlo simulation methods are widely used in several scientific disciplines. They are flexible and easy to apply, but their corresponding error is sometimes deemed too large. This error can be reduced by increasing the sample size, but a more effective approach is to apply cleverly designedvariance reduction techniques. Control variates is an example of such a technique. It aims at reducing the Monte Carlo estimator's variance using a correcting factor that depends on the distance between a control variate and its expectation. This article explains how to use this technique and why it works.
Fear of Movement and Associated Factors Among Adults With Symptomatic Knee Osteoarthritis
Authors: Gunn Alexander H. , Schwartz Todd A. , Arbeeva Liubov S. , Callahan Leigh F. , Golightly Yvonne , Goode Adam , Hill Carla H. , Huffman Kim , Iversen Maura D. , Pathak Ami , Taylor Shannon Stark , Allen Kelli D. 
Published: March 2017

ObjectiveTo examine the frequency of and factors associated with fear of movement (FOM) among patients with symptomatic knee osteoarthritis (KOA), using the new Brief Fear of Movement (BFOM) measure.MethodsParticipants (n = 350) enrolled in a clinical trial completed the BFOM scale prior to randomization. The relationships of BFOM with the following characteristics were examined: age, sex, race, education, pain and activities of daily living (ADL) subscales of the Knee Injury and Osteoarthritis Outcome Score (KOOS), knee symptom duration, depressive symptoms (8‐item Patient Health Questionnaire [PHQ‐8]), history of falls and knee injury, family history of knee problems, self‐efficacy for exercise (SEE), and unilateral balance test. A proportional odds logistic regression model examined multivariable associations of participant characteristics with a 3‐level BFOM variable (agreement with 0, 1–2, or ≥3 items).ResultsThe majority of participants (77%) agreed with at least 1 item on the BFOM scale, and 36% endorsed 3+ items, suggesting a high degree of FOM. In the multivariable model, the following remained significant after backward selection: age (odds ratio [OR] 0.79 per 10‐point increase, 95% confidence interval [95% CI] 0.66–0.95), KOOS ADL (OR 0.86 per 10‐point increase, 95% CI 0.76–0.97), PHQ‐8 (OR 1.15, 95% CI 1.08–1.22), and SEE (OR 0.87 per 10‐point increase, 95% CI 0.78–0.96).ConclusionFOM was common among patients with symptomatic KOA, and this could negatively impact physical activity. Psychological variables were significantly associated with FOM, suggesting behavioral and psychological interventions may decrease FOM and improve outcomes among individuals with symptomatic KOA.
Asymmetric [4+2] Annulation of C1 Ammonium Enolates with Copper‐Allenylidenes
Authors: Song Jin , Zhang Zi‐Jing , Gong Liu‐Zhu 
Published: March 2017

AbstractAn asymmetric catalytic decarboxylative [4+2] annulation of 4‐ethynyl dihydrobenzooxazinones and carboxylic acids has been established by cooperative copper and nucleophilic Lewis base catalysis. A C1 ammonium enolate and copper–allenylidene complex, each catalytically generated from different substrates, underwent a cascade asymmetric propargylation and lactamization process to yield optically active 3,4‐dihydroquinolin‐2‐one derivatives with excellent levels of stereoselectivity (up to 99 % ee, 95:5 d.r.).