bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcomes in patients with chronic limb-threatening ischemia and infected ulcers following endovascular therapy are pathogen dependent: A single-center experience from 2012 to 2021
Authors: Salm Jonas , Ikker Franziska , Böhme Tanja , Noory Elias , Beschorner Ulrich , Kramer Tobias Siegfried , Rieg Siegbert , Westermann Dirk , Zeller Thomas 
Published: September 2024

Background: Patients with chronic limb-threatening ischemia (CLTI) and infected leg ulcers are at risk of amputation and postinterventional sepsis. Methods: This retrospective, single-center study included patients with CLTI and infected leg ulcers who underwent endovascular treatment (EVT) between 2012 and 2021. Results: The study included 712 patients, 286 (40.2%) of whom underwent amputation (minor, n = 212; major, n = 74). Gram-negative bacteria (GNB) were significantly more prevalent in amputees (36.4% vs 30.9%, p < 0.05). Patients with gram-positive bacteria (GPB) had a 4-year freedom from any amputation rate of 72% (95% CI 64–81%) compared to 52% (95% CI 42–66%) in patients with GNB identification ( p < 0.05). Cox proportional regression analysis showed that GNB, male sex, mean Wound, Ischemia, and foot Infection (WIfI) score, diabetes mellitus, and end-stage renal disease were independently and positively associated with amputation ( p < 0.05). The mean WIfI score and end-stage renal disease were independently and positively associated with death from any cause ( p < 0.05). Staphylococcus aureus or GNB, end-stage renal disease, and diabetes mellitus were independent risk factors for sepsis after EVT ( p < 0.05). Inpatient-administered antibiotic regimes had significantly higher microbiological activity in cases of GPB identification compared to GNB identification (28% vs 9%, p < 0.05). Conclusion: Although the isolation of both GNB and S. aureus is a risk factor for sepsis following EVT, the isolation of GNB is independently associated with higher rates of amputation, demonstrating the importance of identifying pathogens to recognize patients at high risk.
Meta-analysis of postoperative urinary incontinence incidence and risk factors in HoLEP
Authors: Yang Mei , Huang Yasheng , Gao Feng , He Liping , Yu Xueyao , Yu Qiqi 
Published: September 2024

Objective: To systematically identify and quantify the incidence and risk factors of postoperative urinary incontinence (UI) in holmium laser enucleation of the prostate (HoLEP), aiming to provide a basis for intervention strategies. Methods: Relevant studies on postoperative UI in HoLEP were searched in databases including PubMed, Web of Science, EMBase, CNKI, Wanfang Data Knowledge Service Platform, VIP and CBMdisc, with the search period up to April 2024. Titles, abstracts and full texts were screened using the Endnote application. Studies meeting the inclusion and exclusion criteria underwent quality assessment and data extraction. The incidence of postoperative UI and/or adjusted or unadjusted odds ratios (OR), relative risks or ratios were recorded, and analysis was conducted using Stata 15.0 software. Results: A total of 17 studies encompassing 7939 patients were included. The pooled incidence of UI after HoLEP was 1.12, 95% CI (1.11–1.13); the 3-month postoperative incidence was 1.06, 95% CI (1.05–1.06); the 6-month postoperative incidence was 1.04, 95% CI (1.03–1.05); the 12-month postoperative incidence was 1.05, 95% CI (1.03–1.06); and the incidence of permanent UI after HoLEP was 1.01, 95% CI (1.00–1.01). The occurrence of UI after HoLEP exhibited a time-dependent variation. The risk factors for UI after HoLEP included the following: age (OR = 1.03, 95% CI: 1.01–1.06); body mass index (BMI; OR = 1.10, 95% CI: 1.01–1.20); prostate volume (OR = 1.77, 95% CI: 1.39–2.27); prostate-specific antigen (PSA) (OR = 0.98, 95% CI: 0.87–0.92); International Prostate Symptom Score (IPSS) (OR = 0.94, 95% CI: 0.83–1.07). Conclusion: The results of this study indicate a decreasing trend in the incidence of postoperative UI after HoLEP over time, with a time-dependent change. Age, BMI, prostate volume, PSA and IPSS are risk factors for postoperative UI after HoLEP. Age and prostate volume have a significant impact on UI. Therefore, preoperative assessment and intervention for these factors are crucial in reducing the occurrence of postoperative UI in HoLEP.
Appraisal of ChatGPT's responses to common patient questions regarding Tommy John surgery
Authors: Shaari Ariana L. , Fano Adam N. , Anakwenze Oke , Klifto Christopher 
Published: September 2024

BackgroundArtificial intelligence (AI) has progressed at a fast pace. ChatGPT, a rapidly expanding AI platform, has several growing applications in medicine and patient care. However, its ability to provide high-quality answers to patient questions about orthopedic procedures such as Tommy John surgery is unknown. Our objective is to evaluate the quality of information provided by ChatGPT 3.5 and 4.0 in response to patient questions regarding Tommy John surgery.MethodsTwenty-five patient questions regarding Tommy John surgery were posed to ChatGPT 3.5 and 4.0. Readability was assessed via Flesch Kincaid Reading Ease, Flesh Kinkaid Grade Level, Gunning Fog Score, Simple Measure of Gobbledygook, Coleman Liau, and Automated Readability Index. The quality of each response was graded using a 5-point Likert scale.ResultsChatGPT generated information at an educational level that greatly exceeds the recommended level. ChatGPT 4.0 produced slightly better responses to common questions regarding Tommy John surgery with fewer inaccuracies than ChatGPT 3.5.ConclusionAlthough ChatGPT can provide accurate information regarding Tommy John surgery, its responses may not be easily comprehended by the average patient. As AI platforms become more accessible to the public, patients must be aware of their limitations.
Evaluating Disaster Management Preparedness among Healthcare Professionals During Pandemics: Palestinian Context
Authors: Aqtam Ibrahim , Shouli Mustafa , Al-qoroum Saqer , Shouli Khaila , Ayed Ahmad 
Published: September 2024

Introduction Emergencies are increasingly prevalent, necessitating specialized management to address significant social disruption. Effective management of health emergencies requires resilience from governments and health institutions, as these emergencies are becoming more common and have wide-ranging consequences on health, society, and the economy. Due to the interconnected nature of our global society, events in one location can have international or even global impacts, as demonstrated by the COVID-19 pandemic. Objective This study aims to assess disaster management preparedness among nurses and physicians during pandemics. Methods This study used an online survey conducted in late 2022 to collect primary data through a purposive sampling method, involving both government and private hospitals in Palestine. The participants included 512 nurses and 241 physicians from various hospital units. Results The findings indicate varying levels of knowledge among participants, with a significant portion (67%) reporting no prior experience with real disaster situations. Additionally, 63% lacked prior disaster response experience. Regarding training courses, 17.8% of nurses and physicians prioritized emergency preparedness, trauma mass casualty response, and triage disaster management systems. Despite some understanding of disaster management, the study emphasizes the importance of hospital managers implementing national standards, engaging healthcare professionals in continuous education, and addressing gaps in perceived competence. Conclusion While participants demonstrated some knowledge of disaster management, the study suggests the importance of hospital managers adopting national standards, engaging healthcare professionals in continuous learning activities, and addressing perceived competence gaps.
Dentists’ Mental Health: Challenges, Supports, and Promising Practices
Authors: Maragha T. , Atanackovic J. , Adams T. , Brondani M. , Bourgeault I. 
Published: September 2024

Objectives: The mental health of dentists, like all health professionals, is a growing concern. The objectives of this study were to identify the mental health challenges experienced by Canadian dentists and to describe the support needs and promising practices to better support them. Methods: This study used a mixed-methods case study design to gather data from semistructured qualitative interviews and a survey for triangulation. Results: Thirty-six dentists and 17 stakeholders participated in the interviews, and 397 dentists participated in the survey. The interview and survey data revealed that dentists have experienced several challenges personally, professionally, and socially. Around 44% of participating dentists experienced a wide range of mental health issues, including depression, anxiety, and posttraumatic stress disorder. Sex/gender shaped the mental health experiences of female dentists, who reported more stress related to caring responsibilities. They had a higher percentage of mental health issues (50%) than men (37%). Caretaking emerged as the main challenge in the social and personal domain, particularly for female dentists in both survey and interview findings. The dentists’ role in practice was one of the most frequently reported professional challenges. While practice owners reported challenges with staff and practice management, associate dentists experienced difficulties with the lack of autonomy and conflicts with office managers and owners. Other challenges reported by participating dentists included patient care responsibilities, loneliness, and isolation. To address these challenges and their impact, dentists and stakeholders identified several support needs and promising practices, including increasing awareness about mental health issues, expanding existing mental health resources, incorporating mental health content in dental education, and encouraging engagement in organized dentistry, particularly for women. Conclusions: The impact of mental health challenges on dentists’ career trajectory and productivity is an ongoing concern in Canada. Gender-specific strategies to support the mental health of dentists should be developed. Knowledge Translation Statement: This study identified the mental health challenges of dentists in Canada to inform the development of interventions and strategies to promote the health and well-being of dentists and dental students. It also highlighted the need for clinicians, students, and individuals in leadership positions in institutions and professional organizations to recognize and consider the working conditions of dentists in various positions to avoid negative consequences on their mental health, reduce the attrition from the professional, and improve patient care outcomes.
PMC Bank Debacle: A Failed Corporate Governance Case
Authors: Shakeel Mohd Raagib , Siddiqui Taufeeque Ahmad , Siddiqui Saif 
Published: September 2024

For sustained business growth, it is imperative to be proactive rather than reactive to issues of public interest. Had the new banking regulation amendments been introduced earlier, could they have prevented the Punjab and Maharashtra Cooperative (PMC) Bank debacle? The bank being put under the limits of the Reserve Bank of India (RBI) for six months was the dreaded headline on 23 September 2019. This was later revealed to be one of the country’s worst financial scams. PMC Bank, a top 10 cooperative bank, was interdicted by the RBI for under-reporting the loan sum sanctioned to HDIL (Housing Development and Infrastructure Limited) and misreporting non-performing assets (NPA) in their annual report. As an immediate consequence, all core activities of the bank came to a halt. Customers who had put their life savings in the bank never imagined that it would result in the deaths of up to eleven people and the devastation of hundreds of homes. It raises an important question about the governance standards upheld by a financial institution such as PMC Bank. Are the recent amendments to the Banking Regulation Act (2020) adequate to strengthen the regulations and corporate governance practices? Furthermore, will these amendments instil trust in a new depositor already perplexed by such news?
Patient-Perceived Challenges to Type 2 Diabetes Self-Management in Sub-Saharan Africa: A Qualitative Exploratory Study
Authors: Desse Tigestu Alemu , Namara Kevin Mc. , Manias Elizabeth 
Published: September 2024

Purpose The purpose of the study was to explore patient-reported challenges influencing type 2 diabetes self-management in a diabetes center in Ethiopia. Methods Exploratory qualitative interviews were conducted with purposively sampled patients with type 2 diabetes. Thematic data analysis was performed to identify challenges to diabetes self-management, and the themes were interpreted using Leininger’s sunrise model. Results Thirty patients with type 2 diabetes participated. Four themes were identified regarding challenges to type 2 diabetes self-management: (1) cultural values and beliefs, (2) kinship and social factors, (3) educational factors, and (4) economic conditions. Sociocultural factors and low income intersected to significantly impede effective diabetes self-management. Sociocultural contexts strongly influenced patient beliefs and interpretations related to diabetes self-care. Misconceptions and limited awareness of diabetes, reliance on herbal remedies, ritual fasting, and prioritization of family needs over individual needs also involved challenges for diabetes self-care. Poverty influenced access to diabetes care. Many patients faced difficulties in adhering to healthy diets for diabetes due to limited income and food costs, and some patients reduced medication doses, including insulin, to manage costs effectively. Conclusion The study highlighted the pressing need for comprehensive and culturally appropriate patient education and empowerment interventions involving various stakeholders to enhance knowledge, understanding, and self-efficacy in diabetes self-management. Urgent attention is needed to ensure patients have access to affordable and sustainable diabetes medications and healthy diets for diabetes through financial incentives. These findings can be considered in designing tailored strategies for improving self-management practice in diabetes care in Ethiopia.
An anti-eCIRP strategy for necrotizing enterocolitis
Authors: Nofi Colleen P. , Prince Jose M. , Brewer Mariana R. , Aziz Monowar , Wang Ping 
Published: September 2024

Abstract
Background
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease characterized by intestinal inflammation and injury, with high mortality risk. Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently discovered damage-associated molecular pattern that propagates inflammation and tissue injury; however, the role of eCIRP in NEC remains unknown. We hypothesize that eCIRP exacerbates NEC pathogenesis and the novel eCIRP-scavenging peptide, milk fat globule-epidermal growth factor-factor VIII (MFG-E8)-derived oligopeptide 3 (MOP3), attenuates NEC severity, serving as a new therapeutic strategy to treat NEC.

Methods
Stool samples from premature neonates were collected prospectively and eCIRP levels were measured. Wild-type (WT) and CIRP−/− mouse pups were subjected to NEC utilizing a combination of hypoxia and hypercaloric formula orogastric gavage with lipopolysaccharide supplementation. In parallel, WT pups were treated with MOP3 or vehicle. Endpoints including NEC severity, intestinal injury, barrier dysfunction, lung injury, and overall survival were determined.

Results
Stool samples from NEC neonates had elevated eCIRP levels compared to healthy age-matched controls (p < 0.05). CIRP−/− pups were significantly protected from NEC severity, intestinal injury, bowel inflammation, intestinal barrier dysfunction, lung injury, and systemic inflammation. NEC survival was 100% for CIRP−/− pups compared to 65% for WT (p < 0.05). MOP3 treatment recapitulated the benefits afforded by CIRP-knockdown, preventing NEC severity, improving inflammatory profiles, and attenuating organ injury. MOP3 treatment improved NEC survival to 80% compared to 50% for vehicle treatment (p < 0.05).

Conclusions
eCIRP exacerbates NEC evidenced by protection with CIRP-deficiency and administration of MOP3, a CIRP-directed therapeutic, in a murine model. Thus, eCIRP is a novel target with human relevance, and MOP3 is a promising treatment for lethal NEC.
Pumpkin seed oil: unveiling its potential in controlling inflammation and pathogenicity during experimental trichinellosis
Authors: Abdel-Hakeem Sara Salah , Alnasser Sulaiman Mohammed , Meshal Alotaibi , Abdel-Samiee Mahmoud Abdel-Zaher , Youssef Mohamed Salah Eldin , Elsadek Shimaa Hamdi Abd , Abd-Elrahman Salwa Mahmoud 
Published: September 2024

Abstract
Background
This study aimed to investigate the antiparasitic and anti-inflammatory potential of pumpkin seed oil in mice infected with Trichinella spiralis by demonstrating its impact on MMP-9 expression and pathogenesis during the intestinal and muscular phases.

Results
In this study, 100 mice were divided into five groups: an infected group, a pumpkin seed oil-treated group (1.5 mg/kg BW, administered three times per week), an albendazole-treated group, a native control group, and a pumpkin oil control group. Gas chromatography–mass spectrometry analysis of the pumpkin seed oil revealed a broad spectrum of biologically active compounds. The pumpkin seed oil treatment led to a significant reduction in the parasite burden, with a 75% decrease in adult worms and a 66% decrease in encysted larvae. Additionally, the infected animals treated with pumpkin oil exhibited a marked reduction in intestinal inflammation, characterized by a progressive increase in goblet cells. The number of encysted larvae in the diaphragm and muscle tissues was also significantly decreased. Furthermore, pumpkin seed oil treatment significantly reduced MMP-9 levels in both intestinal and muscular tissues, highlighting its potential to attenuate inflammation.

Conclusion
These findings underscore the effectiveness of pumpkin seed oil as anti-inflammatory and antiparasitic agent.
Exploring stroke survivors’ and physiotherapists’ perspectives of the potential for markerless motion capture technology in community rehabilitation
Authors: Faux-Nightingale Alice , Philp Fraser , Leone Enza , Helliwell Brinton Boreman , Pandyan Anand 
Published: September 2024

Abstract
Introduction
Many stroke survivors do not receive optimal levels of personalised therapy to support their recovery. Use of technology for stroke rehabilitation has increased in recent years to help minimise gaps in service provision. Markerless motion capture technology is currently being used for musculoskeletal and occupational health screening and could offer a means to provide personalised guidance to stroke survivors struggling to access rehabilitation.

Aims
This study considered context, stakeholders, and key uncertainties surrounding the use of markerless motion capture technology in community stroke rehabilitation from the perspectives of stroke survivors and physiotherapists with a view to adapting an existing intervention in a new context.

Methods
Three focus groups were conducted with eight stroke survivors and five therapists. Data were analysed using reflexive thematic analysis.

Results
Five themes were identified: limited access to community care; personal motivation; pandemic changed rehabilitation practice; perceptions of technology; and role of markerless technology for providing feedback.

Conclusions
Participants identified problems associated with the access of community stroke rehabilitation, exacerbated by Covid-19 restrictions. Participants were positive about the potential for the use of markerless motion capture technology to support personalised, effective stroke rehabilitation in the future, providing it is developed to meet stroke survivor specific needs.
Freshwater snail-borne parasitic diseases in Africa
Authors: Gaye Papa Mouhamadou , Doucouré Souleymane , Sow Doudou , Sokhna Cheikh , Ranque Stéphane 
Published: September 2024

Abstract
Background
Freshwater snails are the first obligatory intermediate hosts in the trematode life cycle. Several parasitic diseases transmitted by these snails are endemic in Africa, and their distribution closely follows that of the intermediate hosts. These diseases represent a major public health problem and cause significant socio-economic losses in Africa, particularly schistosomiasis and fascioliasis. In this review, we will describe the main roles of freshwater snails in the life cycle of trematode parasites, and the geographical distribution of these diseases in Africa. We will also discuss the different techniques for detecting parasitic infections in snails, as well as the various methods of controlling snails and the larval stages of parasites.

Methods
We carried out a literature search for articles dealing with parasitic diseases transmitted by freshwater snail hosts in Africa. The search was conducted in databases such as PubMed, Web of Science and Google Scholar using various search terms combined by Boolean operators. Our search was limited to peer-reviewed articles less than 10 years old. Articles published to date in the fields of control of parasitic diseases transmitted by freshwater snails were included. Results were presented in narrative and in table format.

Results
The results of the database search identified 1007 records. We included 84 studies in this review. These studies generally focused on freshwater snails and the diseases they transmit. We described the geographical distribution of 43 freshwater species belonging to nine snail families, as well as the parasites that infect them. Several methods for diagnosing parasites in their snail hosts have been described, including microscopic and molecular methods, as well as antibody and protein barcode-based techniques. Molluscicides have been described as the main strategy for snail control.

Conclusion
This study highlights several elements of knowledge about diseases transmitted by freshwater snails and their distribution. A good understanding of snail infection detection techniques and existing control methods is an essential component in adapting control strategies for these diseases.

Graphical Abstract