bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human dermal allograft augmentation in primary and revision arthroscopic rotator cuff repair: a retrospective controlled study including patient outcomes and ultrasound evaluation of tendon healing
Authors: Merolla Giovanni , Bonfatti Rocco , Marra Francesco , Pellegrini Andrea , Cataldo Giacomo , Saporito Marco , Paladini Paolo , Porcellini Giuseppe 
Published: October 2024

Abstract

Purpose: Rotator cuff (RC) tears are common in older adults, often leading to muscle atrophy. Standard arthroscopic repair has high re-tear rates, prompting the use of biological patches for augmentation. This study assessed differences in range of motion, strength, and tendon healing using ultrasound in primary and revision RC repairs using acellular dermal allograft augmentation.
Methods: Forty-eight patients undergoing arthroscopic RC repair with dermal allograft augmentation were assessed, with 42 completing a median follow-up of 32.4 months. Twenty patients had primary repairs and 22 had revision procedures. A control group of 26 patients, matched for age, sex, BMI, and RC injury type, underwent RC repair without patch augmentation. Active range of motion, Constant-Murley socre (CS), Simple Shoulder Test (SST), Subjective Shoulder value (SSV) and isometric strength were measured. Tendon healing was assessed via dynamic US.
Results: Both primary and revision groups showed significant improvements in clinical scores and shoulder mobility. However, the primary group had significantly higher postoperative CS, SST and SSV scores. Strength tests indicated lower values in the revision group compared to primary and control groups. Ultrasound outcomes showed reduced tendon thickness in 23 patients, with similar repair integrity across groups. Five cases of RC re-tears were noted, with higher but not significantly different re-tear rates in the revision group
Conclusion: Dermal allograft augmentation in RC repair leads to significant clinical improvement in both primary and revision cases, but strength recovery is less pronounced in revision repairs. Long-term follow-up is necessary to validate these findings and assess the durability of tendon healing.
Level of evidence: Level III, Retrospective cohort design, Treatment study
Retrospective comparison of left ventricular systolic dysfunction assessed by left ventricular global longitudinal strain in hemodialysis patients with preserved left ventricular ejection fraction and patients with hypertensive left ventricular hypertrophy
Authors: Ohno Michiya , Segawa Tomonori , Noda Tetsuo , Yasuda Yoshinari , Yamamoto Junichiro 
Published: October 2024

Abstract

Background
Multiple factors, including hypertension, affect left ventricular remodeling in hemodialysis (HD) patients. Therefore, this retrospective study used left ventricular global longitudinal strain (GLS), an excellent method for detecting mild left ventricular systolic dysfunction, to compare left ventricular systolic function in HD patients with preserved left ventricular ejection fraction (LVEF) and patients with hypertensive left ventricular hypertrophy (HLVH).
Methods
Participants were aged 60 years or older and had an LVEF of 60% or higher. We compared 20 HD patients (HD group) with 20 HLVH patients matched for age and sex (HLVH group) and 20 healthy control individuals (C group). GLS decline was defined as a GLS value greater than the GLS reference value, which was the mean value of + 2×standard deviation in the C group.
Results
LVEF was not significantly different between the 3 groups, but GLS was significantly worse in the HD group (-15.8%±1.4%) than in the C group (-19.3%±1.1%, p < 0.01) and HLVH group (-17.0%±1.4%, p < 0.05). Relative wall thickness (RWT) and left ventricular mass index (LVMI) were significantly higher in the HLVH and HD groups than in the C group (p < 0.01), and hemoglobin (Hb) levels were significantly lower in the HD group than in the C and HLVH groups (p < 0.01). The frequency of GLS decline (i.e., GLS>-17.0%) was significantly higher in the HD group than in the HLVH group (p < 0.01). Multiple regression analysis of the 3 groups showed that increased RWT and LVMI and decreased Hb were significantly associated with GLS decline (p < 0.01).
Conclusions
HD patients with preserved LVEF have a significantly greater decline in GLS than HLVH patients. Increased RWT and LVMI with renal anemia may contribute to GLS decline in HD patients with LVEF.
The practice and exploration of integrating medical science popularization skills into the clinical training of pediatric resident doctors in China
Authors: Zhang Jiahui , Fan Sainan , Xie Lingling , Fang Xiaohui , Chen Jiayi , Zhang Jinping 
Published: October 2024

Abstract

In China, with the development of society and the growing public demand for health knowledge, the importance of medical science popularization has become increasingly prominent.An excellent clinician in the new era is not only to treat diseases, but also requires that in addition to the work of disease treatment itself, more people can vividly understand the causes of diseases, clinical manifestations, treatment, and how to prevent diseases through their own science popularization. Therefore,standardized medical science popularization training is particularly important in the training process of medical resident.This study explored the value of integrating medical science popularization skills into the clinical training of pediatric resident trainees, based on the professional characteristics of pediatrics in comprehensive hospitals and the actual situation of pediatric resident trainees' rotational learning in pediatrics.Through questionnaire survey, targeted improvement and design were carried out to analyze the cognition and self-benefit of pediatric resident students' knowledge of popular science, the importance attached to popular science of pediatric residents, how pediatricians in the residential training base should do, as well as the challenges and problems, strategies and suggestions faced by integrating medical science popularization skills into clinical training of pediatric resident students.From these four aspects, this paper summarized how to better integrate medical science skills into clinical training, so as to cultivate residents' awareness and ability of medical science popularization.Pediatric resident trainees not only improve their own medical skills, but also lay a solid foundation for better science popularization work in the future when they go to work in pediatrics.This study provides useful reference and inspiration for further improving the model of combining medical science popularization with clinical training.
Identification of nuclear pore proteins at plasmodesmata
Authors: Frommer Wolf , Schladt Moritz , Miras Manuel , Ejike Jona , Pottier Mathieu , Xi Lin , Restrepo-Escobar Andrea , Nakamura Masayoshi , Puetz Niklas , Haensch Sebastian , chen.gao@hhu.de Chen , Engelhorn Julia , Dickmanns Marcel , Davis Gwendolyn , Dalal Ahan , Gombos Sven , Lange Ronja , Simon Rüdiger , Schulze Waltraud 
Published: October 2024

Abstract

Plasmodesmata (PD) exchange small molecules, RNAs and proteins between plant cells with an exclusion limit for passive, non-specific transport. PD also facilitate the transport of specific cargo that may require chaperones or carriers for transport. The mechanisms underlying PD transport are not understood. PD and nuclear pore complexes (NPC), are nanometer size micropores with similar transport properties. The permeability barrier in NPCs is a phase separation domain formed by FG-nucleoporins (FG-NUP). Here we used bioinformatics, proteomics and fluorescence imaging to identify proteins with similarities to phase separating FG-NUPs at PD. We identified 20 NUPs in PD fractions, and validated dual localization to NPC and PD for 7 NUPs. Structured illumination microscopy detected the transmembrane anchor NUP CPR5 at both orifices of PD. cpr5 mutants showed reduced intercellular transport of SHR from stele to endodermis. The identification of FG-NUPs at PD is consistent with the recruitment of NUPs in the green lineage to form a PD pore gating complex consistent with liquid phase separation domains as diffusion barriers at PD.
MS-275 enhances osseointegration in osteoporotic rats by inhibition of oxidative stress through activating the miR-200a/keap1/Nrf2 axis
Authors: Yan Junjie , Gu Qinsong , Li Jianqiao , Zhou Zhi , Jiang Wenkai , Guan Wengang , Chen Bin , Chen Yuhu , Yang Min 
Published: October 2024

Abstract

Osteoporosis is a common bone disease worldwide, and oxidative stress has been shown to play an important role in this process. Therefore, reducing the excessive oxidative stress of osteoblasts is a potential strategy for the treatment of osteoporosis. Although, MS-275 has been reported to inhibit oxidative stress, whether it can protect osteoblasts against oxidative stress damage remains to be clarified. This study investigated whether MS-275 can inhibit oxidative stress and promote osteogenesis by activating the miRNA-200a/Keap1/Nrf2 signaling pathway. In vitro, MC3T3-E1 cells were induced by carbonyl cyanide 3 chlorophenylhydrazone, and the oxidative stress model was established. In vitro, MS-275 treatment of oxidation-induced MC3T3-E1 cells resulted in up-regulation of osteoblast protein, increased expression of miRNA-200a, increased binding of miRNA-200a to Keap1 mRNA, decreased expression of Keap1 protein, and dissociation of Nrf2 from Keap1. The expressions of total Nrf2, nuclear Nrf2 and HO-1 were increased, mitochondrial function was enhanced, and oxidative damage was reduced. However, these effects were reversed after interference with miRNA-200a. In vivo, using a rat model of ovariectomized osteoporosis, MS-275 effectively enhanced the microstructural features of distal femoral trabecular bone, increased the mineralization capacity of osteoblasts, and promoted bone formation. Finally, our findings suggest that MS-275 can reverse oxidative stress-induced cell damage, promote bone healing, and improve osteoporosis by activating the miRNA-200a/Keap1/Nrf2 pathway.
Bayesian Dynamic Borrowing in Group-Sequential Design for Medical Device Studies
Authors: Chiaruttini Maria Vittoria , Lorenzoni Giulia , Gregori Dario 
Published: October 2024

Abstract

Background
Medical device technology evolves rapidly, with shorter lifecycles compared to pharmaceuticals. This acceleration necessitates swift safety and efficacy assessments to keep pace with technological advancements. In this context, leveraging clinical data from previous device versions is crucial to reducing enrollment periods and accelerating development, particularly because medical devices often share similar mechanisms. Bayesian Dynamic Borrowing has emerged as an approach that adjusts the weight of historical information based on the congruence between past and new data, enabling unbiased data augmentation.
Methods
This study explores the efficiency of a new study design algorithm that combines Bayesian Dynamic Borrowing with Group-Sequential Design theory. A phase 4 clinical trial on a new medical device for the patent foramen ovale closure has been used as motivating example, and 4 past studies on the control device have been used for the prior elicitation. Simulations were conducted under both the assumption of exchangeability (congruent scenarios) and non-exchangeability (incongruent scenarios) between historical and current control data to evaluate the design's operating characteristics.
Results
The proposed algorithm, when tested under the congruent scenarios, demonstrated its ability to reduce the expected new enrolled patients (2,790 vs. 4,848 under H0, and 3,846 vs. 4,848 under H1) while maintaining both Type I error and Power at their nominal values. Additionally, the asymmetric early stopping boundaries allow a high percentage of trials to be stopped under the null hypothesis (71% at the first interim). The simulations under incongruence scenarios demonstrate how the proposed algorithm discounts the prior information and reduces the expected borrowed sample size dropping from 395 to 13 and from 575 to 68 in scenarios with the higher degrees of incongruence, under Null and Alternative hypotheses, respectively.
Conclusions
In summary, this paper underscores the potential advantages of incorporating Bayesian Dynamic Borrowing with Group-Sequential Design within clinical trial design for medical device studies. The proposed method effectively discounts historical data, maintains control over Type I error and Power, and ensures ethical considerations through early stopping boundaries. In addition, this approach offers considerable flexibility through parameter customization, facilitating more effective collaboration between statistical and clinical specialists.
Acute Kidney Injury After Double-J Stent Placement in a Diabetic Patient with Multiple Comorbidities: A Case Report
Authors: Aljaghoub Ansam , Alassali Anhar , Quraish Areeb 
Published: October 2024

Abstract

Background:
Acute kidney injury is considered a potential rare complication of Ureteral stent placement, but it can happen, especially in patients with multiple comorbidities.
Case Presentation:
We report a case of a 71-year-old male patient with a history of diabetes mellitus (DM), hypertension (HTN), and dyslipidemia, who was also suffering from ischemic heart disease treated by percutaneous coronary intervention (PCI) and stenting two months ago. The patient presented with obstructive pyelonephritis, experiencing stabbing flank pain and hematuria for 4 days. Initial investigations revealed obstructive uropathy due to a left ureteric stone, and laboratory results indicated a creatinine level of 3.1 mg/dL. Despite ongoing prasugrel (antiplatelet) medication, an urgent double-J (DJ) stent placement was attempted but failed due to severe obstruction. Hence, the plan was to discontinue prasugrel and start enoxaparin for 5 days, during which time he received intravenous antibiotics and fluids, showing progressive improvement in creatinine levels. Following the second DJ stent placement surgery, the patient experienced worsening bilateral flank pain, nausea, vomiting, and a significant increase in creatinine, peaking at 4.31 mg/dL. The patient had full management inclusive of volume and electrolyte assessment. A gradual improvement in kidney function was observed over the following weeks.
Conclusion:
This case highlights the interplay between stent placement, antiplatelet management, and AKI risk in a diabetic elderly patient, by which we hope to underscore the need for careful perioperative planning and monitoring.
Symptoms burden of long COVID on the individual with pre-existing depression: A longitudinal cohort study
Authors: He Xiaona , Gao Wei 
Published: October 2024

Abstract

Background
Mental health is receiving increasing attention in the field of long COVID. This study aims to compare the differences in long COVID symptoms between individuals with pre-existing depression and those without and assess the impact of pre-existing depression on the risk of long COVID and on the number of symptoms.
Methods
Data were from the Survey of Health, Ageing and Retirement in Europe (SHARE), participants aged 50 and older. Pre-existing depression was assessed by the EURO-D scale (October 2019-March 2020). Long COVID symptoms were reported by participants (June/August 2020 - June/August 2021). We compared the differences in long COVID symptoms among individuals with pre-existing depression and those without pre-existing depression with the Chi-squared test. P values from all tests were corrected using the Holm-Bonferroni correction. A multilevel (random intercept) hurdle negative binomial model was employed to assess the impact of pre-existing depression on the risk of long COVID and the number of symptoms and to explore effect modification by age, gender, and physical diseases.
Results
Of the 2063 participants who contracted COVID-19 (mean [SD] age, 68.0[8.5] years; 1259(61%) women. A higher number of individuals with pre-existing depression reported headache (32.2% vs 25.9%; P value = 0.027), body aches/joint pain (38.5% vs 29.4%; P value < 0.001), and confusion(10.6% vs 7.6%;P value < 0.01) than those without pre-existing depression. Pre-existing depression did not have a statistically significant impact on the risk of long COVID (adjusted OR = 1.00; 95% CI = 0.78–1.26). Among individuals reporting long COVID symptoms, Pre-existing depression was significantly related to the number of symptoms associated with long COVID (adjusted RR = 1.16; 95% CI = 1.07–1.25). The effect of pre-existing depression on the number of symptoms is moderated by the comorbid physical conditions.
Conclusions
This suggests a complex interplay between pre-existing depression and physical health, highlighting the importance of considering mental health factors in the management of long COVID patients.
Rice bran ameliorated DSS-induced colitis by suppressing inflammation and modulating gut microbiota
Authors: Lv Chenglong , Li Xin , Li Xiangfei , Pang Xinyi , Lu Yingjian 
Published: October 2024

Abstract

Globally, the incidence of colitis is on the rise. Rice bran (RB) is a promising natural dietary supplement. The research aimed to explore how RB impacts colitis in mice caused by dextran sulfate sodium. Notably, administering RB led to better weight control, better colon lengths, and a decreased disease activity index. Furthermore, it was discovered that RB boosts antioxidant abilities, elevates short-chain fatty acids concentrations, fortifies the intestinal mucosal barrier, lowers histopathology scores, and suppresses inflammation. The Ileibacterium vane's relative abundance was greater in colitis mice. Administering RB led to a reduction in the comparative abundance of Ileibacterium vans and exhibited an increased abundance of Akkermansia muciniphila. These findings provide a scientific basis for the development of RB as a natural dietary supplement to improve gut microbiota dysbiosis and enhance the comprehensive utilization value of RB.
Advanced COVID-19 Severity Prediction with Differential Weibull Polar Lights Optimizer and Case Study Insights
Authors: Shang Caibing , Huang Meifang , Yu Sudan 
Published: October 2024

Abstract

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a global health crisis, creating an urgent need for accurate predictive models to forecast disease severity and assist in clinical decision-making. This study presents an innovative machine learning approach, the bDWPLO-FKNN model, to predict the severity of COVID-19 pneumonia in patients. The model integrates the differential Weibull polar lights optimizer (DWPLO), an enhancement of the polar lights optimizer (PLO) with the differential evolution operator and the Weibull flight operator, to perform effective feature selection. The DWPLO's performance was rigorously tested against IEEE CEC 2017 benchmark functions, proving its robust optimization capabilities. The binary version of DWPLO (bDWPLO) was then combined with the fuzzy K-nearest neighbors (FKNN) algorithm to form the predictive model. Utilizing a dataset from the People's Hospital Affiliated with Ningbo University, the model was trained to identify patients at risk of developing severe pneumonia due to COVID-19. The bDWPLO-FKNN model demonstrated exceptional predictive accuracy, with an accuracy of 84.036%, and specificity of 88.564%. The analysis highlighted key predictors, including albumin, albumin to globulin ratio, lactate dehydrogenase, urea nitrogen, gamma-glutamyl transferase, and inorganic phosphorus, which were significantly associated with disease severity. The integration of DWPLO with FKNN not only enhances feature selection but also improves the model's predictive power, offering a valuable tool for clinicians to assess patient risk and allocate healthcare resources effectively during the COVID-19 pandemic.
Diagnosis and treatment of lateral to medial diagonal injury of the elbow in children: Concomitant lateral condyle and olecranon fractures
Authors: Lu Yunan , Xue Chentao , Canavese Federico , Xia Yongjie , Yan An , Pan Yuchen , Chen Shunyou 
Published: October 2024

Abstract

Purpose
Lateral condylar (LC) and olecranon (OC) fractures occurring concurrently on one side are rare phenomena with limited scientific literature. Our study aims to evaluate the radiologic, clinical and functional consequences of lateral to medial injury of the elbow (LAMEINE) in pediatric patients, simultaneously comparing with medial to lateral injury of the elbow (MELAINE).
Methods
Eighteen males and 10 females were diagnosed with LAMEINE. The average age at the time of injury was 3.8 ± 2.3 years (range, 1–9). Out of the 28 fractures, 19 (67.9%) occurred on the left side and nine (32.1%) on the right side. The OC fractures were classified according to the Weiss system, 2 being type I, 17 type II, and 9 type III fractures. Based on the specific case characteristics, the OC fractures were further subdivided into five types corresponding to 2 types of AO classification: 24 (85.7%) cases of AO 21u-M/2. 1 incomplete fractures [(3 type I (10.7%), 16 type II (57.1%), and 5 type III fractures (17.9%)], and 4 (14.3%) cases of AO 21u-M/3.1 complete simple fractures [(2 type IV (7.1%), and 2 type V fractures (7.1%)]. All patients underwent surgical intervention. Their clinical and functional outcomes were evaluated using the carrying angle (CA) and EPS. These results were then compared with those of our MELAINE patients.
Results
All patients were followed up for 42.9 ± 23.5 months (range, 15–88). Radiographs indicated that all fractures healed in 5.9 ± 1.4 weeks (range, 4–10). At the last follow-up, the CA and EPS of the injured side were 11.3° ± 2.8° and 97.7 ± 3.7, respectively. All patients had favorable outcomes: 27 patients (96.4%) had excellent EPS, and only 1 patient (3.6%) had good EPS. The LAMEINE group displayed lower age, displacement, incidence of elbow dislocation, and CA than the MELAINE group (P < 0.05).
Conclusions
Although relatively rare, LAMEINE should not be neglected. Surgical treatment aims to stabilize the elbow and avoid varus deformity. With appropriate diagnosis and treatment, good clinical and radiographic outcomes can be achieved for both patterns of "diagonal lesions" of the pediatric elbow.
Level of evidence: III