bluuebunny/crossref_metadata_2025_split huggingface dataset:
The formation and deformation of the Neogene Pannonian Basin: a structural overview
Authors: Csontos László , Dunkl István , Koroknai Balázs , Tari Gábor , Soós Balázs , Magyari Árpád , Nyíri Dániel , Soták Ján , Wórum Géza , Tóth Tamás , Kovács Gábor 
Published: September 2024

The Pannonian Basin is a continental back-arc basin. Palaeomagnetics defined three terranes: Alcapa (Alps–Carapathians–Pannonian), Tisza–Dacia and Dinarides, rotated counterclockwise, clockwise and counterclockwise, respectively, in the Early and Middle Miocene. The timings and the extent of rotations suggest the terranes experienced differential internal rotations.

Metamorphic core complexes occur along the margins and an internal part of the Pannonian Basin. Metamorphic core complexes display extension parallel then perpendicular to the margins. Low-temperature thermochronology defined that synrift exhumation occurred
c.
18–16 Ma, coeval with map-view rotations.

Microtectonic measurements evidenced superimposed fault patterns. When combined with palaeomagnetics, these patterns simplify to north–south compression throughout Late Paleogene–Middle Miocene. Complications result from rotating blocks deforming under this external stress field.
Interpretation of seismic reflection data suggest that synrift phase was characterized by two perpendicular extensions. When rotations are considered, these resolve in east–west stretching. Strike-slip faulting during the Late Miocene accommodated differential movement of terranes pulled eastwards by slab roll-back along the Carpathians.
Several inversions affect Late Miocene–Recent sediments. These are most intense and earliest in the SW Pannonian Basin, but also propagate into the internal parts. Rotational indentation of Adria into the Southern Alps–Western Dinarides is the main cause for inversion. Neotectonics reflect this inversion, that is enhanced by eastwards escaping Eastern Alps.
The Differentiation Potential of Apical Papilla Cells in Relation to Tenascin‐C and Syndecan‐1 Expression and Their Potential Role in Regeneration
Authors: Kodonas K. , Fardi A. , Papadimitriou S. , Gogos C. 
Published: September 2024

Introduction: This study investigated the distribution pattern of tenascin‐C and syndecan‐1 in the dental mesenchyme during root development of immature swine teeth in order to define the differentiation dynamics of both pulp tissue progenitors and apical papilla cells, as well as to assess the adequacy criticize of the apical papilla to induce dentin–pulp regeneration.Methods: Three 7‐month‐old miniature swine were used in this study. A total of 12 teeth, including two immature permanent incisors and two premolar teeth of each case, were extracted and processed for histological and immunohistochemical analysis. Different populations of mesenchymal cells located at the root apex were morphologically evaluated in hematoxylin–eosin serial sections. Additionally, the distribution patterns of tenascin‐C and syndecan‐1 were assessed immunohistochemically.Results: Syndecan‐1 was strongly expressed in the dental pulp, particularly along the odontoblasts of the root and the newly deposited predentin layer. Tenascin‐C was intensely expressed in the dental pulp. The apical papilla and dental follicle showed no expression of either molecule.Conclusions: Cell differentiation potential in the developing swine apex is progressively restricted to the newly formed dental pulp, whereas phenotypic expression of apical papilla cells remains undetermined unless the new microenvironment triggers cell differentiation towards the odontoblastic lineage.
Targeting BTN2A1 Enhances Vγ9Vδ2 T-Cell Effector Functions and Triggers Tumor Cell Pyroptosis
Authors: Le Floch Anne-Charlotte , Imbert Caroline , Boucherit Nicolas , Gorvel Laurent , Fattori Stéphane , Orlanducci Florence , Le Roy Aude , Archetti Lorenzo , Crescence Lydie , Panicot-Dubois Laurence , Dubois Christophe , Vey Norbert , Briantais Antoine , Anastasio Amandine , Cano Carla , Guittard Geoffrey , Frechin Mathieu , Olive Daniel 
Published: September 2024

Abstract
Vγ9Vδ2 T cells are potent but elusive cytotoxic effectors. Butyrophilin subfamily 2 member A1 (BTN2A1) is a surface protein that has recently been shown to bind the Vγ9 chain of the γδ T-cell receptor, but its precise role in modulating Vγ9Vδ2 T-cell functions remains unknown. Here, we show that 107G3B5, a monoclonal BTN2A1 agonist antibody, was able to significantly enhance Vγ9Vδ2 T-cell functions against hematologic or solid cell lines and against primary cells from patients with adult acute lymphoblastic leukemia. New computer vision strategies applied to holotomographic microscopy videos showed that 107G3B5 enhanced the interaction between Vγ9Vδ2 T cells and target cells in a quantitative and qualitative manner. In addition, we found that Vγ9Vδ2 T cells activated by 107G3B5 induced caspase 3/7 activation in tumor cells, thereby triggering tumor cell death by pyroptosis. Together, these data demonstrate that targeting BTN2A1 with 107G3B5 enhances the Vγ9Vδ2 T-cell antitumor response by triggering pyroptosis-induced immunogenic cell death. These new pyroptosis-based therapies have great potential to stimulate the immune system to fight cancer, especially “cold” tumors.
See related Spotlight by Kabelit, p. 1662
Oncogenic Mutant p53 Sensitizes Non–Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress–Dependent Induction of Mitochondrial Apoptosis
Authors: Chougoni Kranthi Kumar , Neely Victoria , Ding Boxiao , Oduah Eziafa , Lam Vianna T. , Hu Bin , Koblinski Jennifer E. , Windle Bradford E. , Palit Deb Swati , Deb Sumitra , Nieva Jorge J. , Radhakrishnan Senthil K. , Harada Hisashi , Grossman Steven R. 
Published: September 2024

Abstract
Non–small cell lung cancer (NSCLC) cells with oncogenic mutant p53 (Onc-p53) alleles exhibit significantly higher levels of proteasome activity, indicating that Onc-p53 induces proteotoxic stress which may be leveraged as a therapeutic vulnerability. Proteasome inhibitors (PI) are most active in cells under proteotoxic stress, so we investigated whether PIs exhibit preferential cytotoxicity in Onc-p53 NSCLC cells. Indeed, bortezomib (BTZ) and other PIs exhibited IC50 values 6- to 15-fold lower in Onc-p53 cells versus wild-type (WT) p53 cells. BTZ cytotoxic effects in Onc-p53 cells were abrogated by antioxidants such as N-acetyl-L-cysteine, indicating that oxidative stress is the critical driver of BTZ-dependent cytotoxic effects in Onc-p53 cells. Importantly, we observed oxidative stress–dependent transcriptional induction of the proapoptotic BH3-only protein NOXA, leading to cleavage of caspase-3, consistent with an apoptotic mechanism of cell death in Onc-p53 but not in WT p53 cells treated with BTZ. BTZ-generated oxidative stress was linked to nuclear translocation of NRF2 and transcriptional activation of ATF3, which in turn was required for NOXA induction. Validating the translational potential of BTZ in Onc-p53 NSCLC cells, BTZ and the BH3-mimetic navitoclax were synergistically cytotoxic in Onc-p53 but not in WTp53 cells in vitro, and BTZ effectively limited the growth of Onc-p53 NSCLC xenografts when combined with navitoclax and carboplatin (a standard-of-care chemotherapeutic in NSCLC) in vivo. Our data therefore support further investigation of the therapeutic utility of PIs combined with BH3-mimetics and chemotherapy in Onc-p53 human NSCLC as a novel therapeutic strategy.

Significance:
NSCLC is the leading cause of cancer death due, in part, to a lack of active therapies in advanced disease. We demonstrate that combination therapy with a proteasome inhibitor, BH3-mimetic, and chemotherapy is an active precision therapy in NSCLC cells and tumors expressing Onc-p53 alleles.
Legal Systems and Loss & Damage at the Ocean-Climate Nexus: a Tribute to Meinhard Doelle
Authors: Seck Sara L 
Published: September 2024

Abstract
In 2021, the Research Handbook on Climate Change Law and Loss & Damage was published. Co-edited by myself and my late colleague Meinhard Doelle, the Handbook seeks to clarify the need for legal systems, both within and beyond the climate regime, to evolve so as to fairly and equitably address climate loss and damage claims. The Handbook considers the challenges of legal remedy for climate loss & damage from the perspectives of public international law and domestic, transnational, and private international law. While loss & damage at the ocean-climate nexus is implicit in many chapters, this contribution will reflect explicitly on how the lessons from the Handbook could apply at the ocean-climate nexus, with reference to the London Convention and Stockholm Declaration at fifty, developments at COP 28, and the Advisory Opinion on Climate Change before the International Tribunal for the Law of the Sea.
A Stocktake of Ocean Governance Fifty Years after Stockholm: New Challenges for International Law
Authors: Oral Nilüfer 
Published: September 2024

Abstract
The 1972 United Nations Conference on the Human Environment (Stockholm Conference) was a milestone as the first global meeting of governments to address threats to the environment, including the ocean and seas. Over the fifty years since the adoption of the Stockholm Declaration, new pressing threats to the marine environment have emerged, such as loss of marine biodiversity, including in the high seas, marine plastic pollution, climate change, and illegal, unregulated, and unreported fishing. This article will review the developments that have taken place at the International Maritime Organization and other bodies of the United Nations to address these new threats to the marine environment, reflecting how international law continues to play a vital role in promotion of ocean governance.
Legitimate Scientific Research: Objective Scientific Assessment of Marine Geoengineering Activities under the London Convention and London Protocol
Authors: Lyons Youna LBL , Santillo David , Catonini Federica 
Published: September 2024

Abstract
Overall interest in marine geoengineering (MGE) techniques and in their potential to mitigate the effects of climate change, as well as the multiple interests driving urgency for deployment, have intensified. This article considers the scientific, measured, transparent, and robust approach taken by the joint-meetings of the Governing Bodies of the 1972 London Convention and the 1996 London Protocol and the regulatory framework they are developing in response, with a particular focus on the regulation and guidelines for legitimate scientific research for MGE activities. It unpacks key attributes of the research assessment framework, particularly its acknowledging and accounting for scientific gaps and uncertainties, as well as its informed application of the precautionary approach. This is especially relevant in the context of rapidly growing interest in MGE as a means of climate mitigation.
Poetic ‘Hypertext’, Evocative ‘Figure-in-Landscape’, and the Reading of Illustrated Plays in the Late Ming
Authors: Wu Yinghui 
Published: September 2024

Abstract
Scholars of late Ming print culture have noted a ‘scenic’ shift in book illustrations of the late Wanli period. But how did the ‘scenic’ style vary across different genres of books, and what impact did such variations have on reading? This article examines a series of drama illustrations attributed to the Hangzhou publisher Rongyu tang (RYT), and explores the RYT’s subtle reconfigurations of the relationships between figures, landscapes, and poetic captions to produce new experiences of reading plays. I argue that the RYT developed its own repertoire of ‘figures-in-landscape’ that, while intersecting with visual motifs in a wide range of paintings and prints, distinguish themselves through the fine-tuning of the relative size of figure to landscape and the integrating of poetic ‘hypertexts’. Through close examination of three figure types – traveler, fisherman, and female performer – in landscape, I show that the images gave rise to a poetically recollective, visually evocative, and culturally contextualized mode of reading that appealed to varying levels of knowledge and interests. They afforded readers the flexibility to immerse themselves in the atmosphere or emotions of select scenes, to reflect on the overarching themes of the plays, or to take an imaginative flight out of drama to appreciate the images’ broader poetic and visual associations.
Contradictions of Culture and Oppression
Authors: Burke S. Maureen 
Published: September 2024

Abstract
Few early eighteenth-century Caribbean paintings survive. Among them is an important pair of previously unpublished Jamaican portraits of Chief Justice Thomas Fearon Jr., of Clarendon, and of his wife, Mary Peters Fearon, with their oldest son, Thomas Peters Fearon, from the 1730s. Colonial reflections of London art and society, although distorted by distance, occupied unique spaces where fantasies and realities collided. This article examines the historical context, provenance, and interpretation of the large, three-quarter-length paintings by an unidentified artist as well as the little that is known about the Jamaican art world at the time. Two unpublished drawings by Pierre du Simitière of Black West Indian women—one enslaved, one free—provide a counterpoint, as do other colonial depictions. The Fearon portraits form a rare pictorial record of a family at the apex of a transatlantic human pyramid of visible privilege and unseen pain, a century before that world ended.
Management of a Piriform Sinus Fistula With Chronic Neck Infection in an Adult
Authors: McMillan Alexandra , Chen Stephanie , Hua Xiaoyang 
Published: September 2024

Objectives: A pyriform sinus fistula (PSF) is a rare congenital anomaly due to failed obliteration of the third or fourth pharyngeal pouch. Diagnosis and management of PSF remains controversial. We present a case of PSF and discuss its diagnosis and management. Methods: Case report and literature review. Results: A 26-year-old female with a chronic left lateral neck abscess was diagnosed with a left PSF. She underwent surgery through a combined approach to close the openings of the PSF, internally and externally. We first placed a blunted ET tube into the internal opening of the PSF. We then performed an external transcervical approach to close the PSF at the cricothyroid membrane. Briefly, after a neck debridement and washout of the chronic neck infection, we identified the recurrent laryngeal nerve (RLN) in Lore’s triangle. We performed left hemithyroidectomy to facilitate the dissection and protection of the RLN to its entrance into the larynx. A flexible laryngoscope was then inserted into the left piriform sinus through the ET tube to guide external dissection by transillumination. The scar tissue attached to the superior pole of the left thyroid lobe was then ligated and divided along the cricothyroid membrane. Lastly, we cauterized the internal opening of the PSF. The patient has remained recurrence-free for 1.5 years with normal vocal cord mobility. Histopathology revealed presence of a squamous-lined tract adjacent to the thyroid tissue. Conclusions: Surgical treatment for patients with PSF should be aimed at closing the internal and external openings of the PSF, debriding chronic neck infection, and protecting the laryngeal nerves, instead of removing the entire tract. A concurrent hemithyroidectomy facilitates the identification and protection of the RLN, as well as excision of the tract. Differentiation between third and fourth branchial cleft fistulae may not be clinically necessary, as it is unlikely to alter the therapeutic plan.
Sensory Reactivity Through the Lived Experiences of Parents of Children with Autism Spectrum Disorder: An Exploratory Phenomenological Qualitative Study
Authors: Rajalakshmi Selvaganapathy , Ranjan Rajeev , Varghese Nidhi Joseph , Bharti Ayushi , Sinha Muskan , Kumar Pankaj , Ahmad Shamshad 
Published: September 2024

Background: The current sensory assessment measures for autism spectrum disorder (ASD) have issues related to cultural and clinical applicability, which makes them difficult to apply in the Indian context consistently. The current study aimed to explore locally relevant themes for sensory reactivity in children with ASD. Methods: This exploratory phenomenological qualitative study was carried out on 15 parents of children with ASD visiting the child guidance clinic. An in-depth interview (IDI) guide was prepared on the conceptual framework based on Dunn, as well as, Miller’s models, which was then further refined based upon the inputs from the experts (psychiatrists, child psychologists, speech-language pathologists, and occupational therapists) working with children with ASD. IDIs were conducted with parents of children with ASD. The data was recorded in audio and video format. It was transcribed and translated from Hindi to English. Coding was done manually, and themes were extracted. Results: The findings identified four superordinate themes: sensory hyperreactivity, sensory hyporeactivity, sensory seeking, and socio-emotional response. Conclusion: The lived experience of parents aids in identifying and describing dimensions of sensory reactivity in children with ASD. It will help further in developing a valid and reliable instrument for the assessment of sensory reactivity in children with ASD.
Which dose of calcium dobesilate is more effective and safe in chronic venous insufficiency? Multicenter retrospective clinical trial
Authors: Arslanturk Oguz , Uymaz Barıs , Gumus Fatih 
Published: September 2024

Objectives This study aimed to evaluate the effectiveness and safety of different dosages of calcium dobesilate in the management of Chronic Venous Insufficiency (CVI) among patients in CEAP classes C3–C4. Methods A comprehensive multicenter retrospective analysis was conducted, including patients aged 18-70 with CEAP class C3–C4 CVI. Participants were divided into two groups: one receiving 500 mg of calcium dobesilate twice daily and the other 1000 mg twice daily. Patient progress was monitored using the Global Index Score, CIVIC-20 Score, and precise measurements of ankle and calf circumferences over a 12-month period. Results The higher dosage group (1000 mg twice daily) showed significant improvements in both symptom relief and edema reduction. Ankle circumference reduced notably at 6 months, while calf circumference and overall quality of life, measured by the Global Index Score, showed significant improvement by 12 months compared to the lower dosage group. Conclusions Higher doses of calcium dobesilate markedly enhance the management of CVI symptoms and reduce edema more effectively than lower doses, particularly in patients with advanced CVI. These findings support the use of higher dosages for optimal treatment, though further research is needed to fully evaluate long-term safety.
The effective dose of butorphanol tartrate in patients of different ages undergoing painless gastroscopy
Authors: Sun Yaorui , Liu Shujiao , Si Wenli , Zhang Quanyi , Yu Fei , Su Ming , Sun Chao 
Published: September 2024

Objective This study evaluated the 50% effective dose (ED50) and 95% effective dose (ED95) of butorphanol tartrate in patients undergoing painless gastroscopy. Methods Patients who underwent painless gastroscopy at Binzhou Medical University Hospital were divided into the youth, middle-aged, and older groups. The ED50 and ED95 required for successful sedation using butorphanol tartrate were measured using the Dixon up-and-down method in patients in the different age groups. Patients in each group were administered intravenous butorphanol 5 minutes before gastroscopy. Each patient was administered 2 mg/kg propofol. The ED50 and ED95 of butorphanol were calculated using probit analysis. Results In total, 95 patients were included. The ED50s of butorphanol in the youth, middle-aged, and older groups were 7.384, 6.657, and 6.364 μg/kg, respectively. The ED95s of butorphanol doses in these groups were 9.108, 8.419, and 7.348 μg/kg, respectively. Conclusions The ED50 and ED95 varied among the age groups, indicating that the effective dose decreases with age.
The effect of modified titanium dioxide, silica, and zinc oxide on the self-cleaning property of an acrylic resin-based paint
Authors: Shahgolzade Hoora , Ostad Movahed Saeed 
Published: September 2024

Traffic paints hold paramount importance in road markings and ensuring efficient traffic flow. Self-cleaning marking traffic paints are a type of paint which recently developed to keep traffic lines clean with high visibility. Several paints were formulated with acrylic resin and self-cleaning agents, titanium dioxide (TiO2), silicon dioxide (SiO2), and zinc oxide (ZnO) individually and or in combination. All agents were treated in a furnace at 800°C for 2 hours before incorporating into the paint formulation. The effect of untreated and treated agents on several crucial properties of the formulated paints was assessed and compared. It revealed that heat treatment was effective on the crystallinity and impurity content of the agents evidenced by traditional characteristic techniques. The SEM-EDX analysis confirmed the presence and distribution of self-cleaning agents in the paint matrix. Water contact angles ranged from 68° to 97° for paints with self-cleaning agents, indicating improved hydrophilicity. Oil contact angles ranged from 27° to 42° for most paints with self-cleaning agents, showing some improvement in hydrophobicity. The qualitative assessment confirmed superior self-cleaning performance for paints with self-cleaning agents compared to the reference paint, especially for treated agents. Overall, the type and amount of self-cleaning agents significantly affect the hydrophilicity, hydrophobicity, and self-cleaning performance of paints.
Problem-Solving and Coping Skills Training for Youth with Deliberate Self-Harm Behaviors: A Scoping Review
Authors: Kpeno Audifax , Sahoo Surjeet , Sahu Amiya Krushna , Sahu Pratap Kumar 
Published: September 2024

Background: There has been an urgent need for the youths to be furnished with the capacity to apply the use of strategies such as problem- solving and coping skills in other to ameliorate their deliberate self-harming behavior inclinations. It is important to recognize the underlying emotional and psychological underpinnings of these self-harming behaviors. Methods: Three data bases; Scopus, Google Scholar advanced search, and PubMed, were searched using keywords such as “problem-solving,” “coping,” “youth,” and “deliberate self-harm.” The articles were then screened to ensure that they all met the inclusion criteria and only those published in the English language were selected and deliberate self-harm.” Result: Deliberate self-harm behaviors pose a substantial risk to the mental health of the individuals involved. Integrating emotional regulation and coping skills has been shown to improve mental health outcomes in these youths significantly. Problem-solving and coping skills programs have emerged as effective interventions for addressing deliberate self-harm behaviors in youth. Those who are engrossed in deliberate self-harm often struggle with problem-solving abilities and resort to maladaptive social problem-solving, such as self-harming, as a coping mechanism. Incorporating problem-solving techniques within therapy approaches can be an effective strategy to address deliberate self-harm behaviors and promote healthier coping mechanisms. Conclusions: There is the need for structured interventions to meet the unique and diverse need of the youths engaged in this act. Interventions can target the core issues, such as emotional dysregulation, interpersonal difficulties, or trauma history.