bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic and molecular correlates of cortical thickness alterations in adults with obsessive–compulsive disorder: a transcription–neuroimaging association analysis
Authors: Zhang Da , Teng Changjun , Xu Yinhao , Tian Lei , Cao Ping , Wang Xiao , Li Zonghong , Guan Chengbin , Hu Xiao 
Published: October 2024

AbstractBackgroundAlthough numerous neuroimaging studies have depicted neural alterations in individuals with obsessive–compulsive disorder (OCD), a psychiatric disorder characterized by intrusive cognitions and repetitive behaviors, the molecular mechanisms connecting brain structural changes and gene expression remain poorly understood.MethodsThis study combined the Allen Human Brain Atlas dataset with neuroimaging data from the Meta-Analysis (ENIGMA) consortium and independent cohorts. Later, partial least squares regression and enrichment analysis were performed to probe the correlation between transcription and cortical thickness variation among adults with OCD.ResultsThe cortical map of case-control differences in cortical thickness was spatially correlated with cortical expression of a weighted combination of genes enriched for neurobiologically relevant ontology terms preferentially expressed across different cell types and cortical layers. These genes were specifically expressed in brain tissue, spanning all cortical developmental stages. Protein–protein interaction analysis revealed that these genes coded a network of proteins encompassing various highly interactive hubs.ConclusionsThe study findings bridge the gap between neural structure and transcriptome data in OCD, fostering an integrative understanding of the potential biological mechanisms.
Digital assessment of nonverbal behaviors forecasts first onset of depression
Authors: Ozturk Sekine , Feltman Scott , Klein Daniel N. , Kotov Roman , Mohanty Aprajita 
Published: October 2024

AbstractBackgroundAdolescence is marked by a sharp increase in the incidence of depression, especially in females. Identification of risk for depressive disorders (DD) in this key developmental stage can help prevention efforts, mitigating the clinical and public burden of DD. While frequently used in diagnosis, nonverbal behaviors are relatively understudied as risk markers for DD. Digital technology, such as facial recognition, may provide objective, fast, efficient, and cost-effective means of measuring nonverbal behavior.MethodHere, we analyzed video-recorded clinical interviews of 359 never-depressed adolescents females via commercially available facial emotion recognition software.ResultsWe found that average head and facial movements forecast future first onset of depression (AUC = 0.70) beyond the effects of other established self-report and physiological markers of DD risk.ConclusionsOverall, these findings suggest that digital assessment of nonverbal behaviors may provide a promising risk marker for DD, which could aid in early identification and intervention efforts.
Callimachus, Conon and Ptolemy: an Alexandrian epigram between geography and astronomy
Authors: Pontani Filippomaria 
Published: October 2024

AbstractA neglected, anonymous and undated epigram on the world map of Ptolemy’s Geography, here critically edited for the first time on the basis of all existing manuscripts, proves a rare case of reception of Callimachus’ Lock of Berenice, with an emphasis on the bonds between geography and astronomy, and with so-called ‘geographical astrology’. It may stem from Late Antique Alexandria.
An intelligent fixed-time super-twisting sliding mode control of the uncertain hybrid mechanism
Authors: Li Xue , Gao Guoqin 
Published: October 2024

AbstractIn order to improve the global convergence performance of the super-twisting sliding mode control (STSMC) for the uncertain hybrid mechanism, especially in the high-speed scenario, and enhance the robustness of hybrid mechanism system to the uncertainties with a wide range of changes, an intelligent fixed-time super-twisting sliding mode control (IFTSTSMC) is proposed. Firstly, a fixed-time super-twisting sliding mode control (FTSTSMC) algorithm is designed by adding the exponential power terms with the fixed-time performance parameters in sliding variables and the transcendental function of the super-twisting algorithm in order to enhance the global convergence performance of the STSMC. Secondly, the existence condition of FTSTSMC for the uncertain hybrid mechanism is analyzed. The IFTSTSMC is designed by introducing RBF neural network to break through the limited range of uncertainties in FTSTSMC and enhance the robustness of hybrid mechanism system to the uncertainties with a wide range of changes. Then, the Lyapunov stability of the proposed method and the global fixed-time convergence of the system are proved theoretically. Finally, the effectiveness and superiority of the proposed control method are verified by the simulation and the automobile electro-coating conveying prototype experiment comparing with two classical finite-time sliding mode control methods.
Late Talkers can generalise trained labels by object shape similarities, but not unfamiliar labels
Authors: Zuniga-Montanez Cecilia , Krott Andrea 
Published: October 2024

Abstract
Late talkers (LTs) exhibit delayed vocabulary development, which might stem from a lack of a typical word learning strategy to generalise object labels by shape, called the ‘shape bias’. We investigated whether LTs can acquire a shape bias and whether this accelerates vocabulary learning. Fourteen LTs were randomly allocated to either a shape training group (Mage = 2.76 years, 6 males), which was taught that objects similar in shape have the same name, or a control group (Mage = 2.61 years, 4 males), which was taught real words without any focus on object shape. After seven training sessions, children in the shape training group generalised trained labels by shape (d = 1.28), but not unfamiliar labels. Children in the control group extended all labels randomly. Training did not affect expressive vocabulary.
Aging and Mental Health: Collaborating on Research Priorities with Older Adults, Caregivers and Health and Social Care Providers across Canada
Authors: Giosa Justine L. , Kalles Elizabeth , Yogaratnam Karthika , Kim Tammy , McNeil Heather , Holyoke Paul 
Published: October 2024

Abstract
Age-related changes can affect mental health, but aging-focused mental health research is limited. The objective was to identify the top 10 unanswered research questions on aging and mental health according to what matters most to aging Canadians. A steering group of experts-by-experience (e.g., older adults, caregivers, health and social care providers) guided three phases of a modified James Lind Alliance priority-setting partnership: (1) a broad national survey (n = 305) and a rapid literature scan; (2) a follow-up national survey (n = 703); and (3) four online workshops (n = 52) with a nominal group technique. Forty-two unique questions on aging and mental health resulted, of which 18 were determined to be answered by existing evidence. Of the 25 partially and unanswered questions, 10 were ranked as top priority. Findings can be used to prioritize future research, knowledge mobilization, and funding decisions, and to promote and support collaboration between longstanding siloed research and care fields.
Six of one, half a dozen of the other? Examining measurement properties of different potentially traumatic event polyvictimization operationalizations using a multiverse analysis framework
Authors: McGuire Austen , Smith Daniel W. , Kilpatrick Dean 
Published: October 2024

Abstract
Numerous differences exist between and within research projects related to assessment and operationalization of potentially traumatic events (PTEs) for youth, especially when measuring polyvictimization. However, few studies have systematically examined how polyvictimization measurement differences influence PTE’s relation to functioning. This study sought to address these knowledge gaps by conducting a secondary data multiverse replication (SDMR) to systematically (re)evaluate PTE polyvictimization measurement approaches. Participants included 3297 adolescents (Mage = 14.63; 50.59% female; 65.15% white) from the National Survey of Adolescents-Replication study who completed a structured interview on PTE exposure and emotional and behavioral health (i.e., posttraumatic stress and major depressive disorder, drug and alcohol use, and delinquency). Results indicated that PTE operationalizations using a count variable tended to demonstrate better model performance and prediction of youth at-risk of emotional and behavioral health challenges, compared to models using a binary (yes/no) PTE operationalization. Differences in model performance and prediction were less distinct between models examining multiple forms of a single type of PTE (e.g., maltreatment, community violence), compared to models examining multiple PTE types. These findings emphasize the importance of using multidimensional approaches to PTE operationalization and the need for more multiverse analyses to improve PTE evidence-based assessment.
Fears of positive and negative evaluation and their within-person associations with emotion regulation in adolescence: A longitudinal analysis
Authors: Tsarpalis-Fragkoulidis Achilleas , Tran Ulrich S. , Zemp Martina 
Published: October 2024

Abstract
Fear of positive evaluation (FPE) has recently emerged as an important aspect of social anxiety, alongside fear of negative evaluation. These evaluation fears peak during adolescence, a developmental stage that is also often accompanied by difficulties in emotion regulation, thereby increasing young individuals’ vulnerability to mental disorders, such as social anxiety. We aimed to examine the longitudinal within-person associations between fears of evaluation, social anxiety, and three emotion regulation strategies (i.e., acceptance, suppression, rumination) in adolescents. Data were collected from a sample of 684 adolescents through an online survey three times over the course of 6 months and were analyzed using random intercept cross-lagged panel models. At the between-person level, FPE was linked to all three emotion regulation strategies, whereas fear of negative evaluation and social anxiety were associated with acceptance and rumination. At the within-person level, difficulties in accepting emotions predicted FPE, suppression predicted social anxiety, and social anxiety predicted rumination over time. These findings reveal complex interdependencies between emotion regulation, social anxiety, and evaluation fears, both reflecting individual differences and predicting changes within individuals, and further elucidate the developmental trajectory of social anxiety in adolescence.
Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing
Authors: Hardi Felicia A. , Peckins Melissa K. , Mitchell Colter , McLoyd Vonnie , Brooks-Gunn Jeanne , Hyde Luke W. , Monk Christopher S. 
Published: October 2024

Abstract
Associations between adversity and youth psychopathology likely vary based on the types and timing of experiences. Major theories suggest that the impact of childhood adversity may either be cumulative in type (the more types of adversity, the worse outcomes) or in timing (the longer exposure, the worse outcomes) or, alternatively, specific concerning the type (e.g., parenting, home, neighborhood) or the timing of adversity (e.g., specific developmental periods). In a longitudinal sample from the Future of Families and Wellbeing Study (N = 4,210), we evaluated these competing hypotheses using a data-driven structured life-course modeling approach using risk factors examined at child age 1 (infancy), 3 (toddlerhood), 5 (early childhood), and 9 (middle childhood). Results showed that exposures to more types of adversity for longer durations (i.e., cumulative in both type and timing) best predicted youth psychopathology. Adversities that occurred at age 9 were better predictors of youth psychopathology as compared to those experienced earlier, except for neglect, which was predictive of internalizing symptoms when experienced at age 3. Throughout childhood (across ages 1–9), aside from the accumulation of all adversities, parental stress and low collective efficacy were the strongest predictors of internalizing symptoms, whereas psychological aggression was predictive of externalizing symptoms.
The rise, expansion, and endurance of Kaanul: The view from northwestern Peten
Authors: Barrientos Q. Tomás , Canuto Marcello A. , Stuart David 
Published: October 2024

AbstractThe ancient Maya political landscape was permeated by regional systems of political asymmetry. These hegemonic networks fluctuated through time, but the steady presence of a few especially dominant polities shows that they were a persistent feature with very real sociopolitical effects. Based on research carried out at the sites of La Corona and Achiotal, and epigraphic studies in many other sites in the Maya Central Lowlands, we offer a general interpretation of the historical and sociopolitical development of one of these hegemonic polities: the Kaanul dynasty. Combining epigraphic and archaeological data, we discuss the Early Classic political landscape in the northern Peten region (“Chatahn” Winik, Suutz', and Sak Wahyis), as well as the development and maintenance of political relations with the Kaanul dynasty for over two centuries. These data allow us to suggest that the northwestern Peten was not only a strategic point for the initial expansion of the Kaanul dynasty in the sixth century a.d., but also an important lynchpin for the maintenance of its hegemonic control in the seventh and eighth centuries a.d. We suggest that epigraphic and archaeological data of the northern Peten from the Classic period help to illuminate how a unique regional hegemony over the Maya Lowlands was achieved and maintained.
The team for a new age: Naranjo and Holmul under Kaanu'l's sway
Authors: Tokovinine Alexandre , Estrada-Belli Francisco , Fialko Vilma 
Published: October 2024

AbstractThe article presents the results of the last decade of archaeological and epigraphic research, which clarified the history of the polities of the ancient Maya sites of Holmul and Naranjo during the expansion of the Dzibanche royal dynasty in the eastern area of the Department of Peten, Guatemala, from the second half of the sixth century through the first half of the seventh century a.d. The discussion centers on the textual and material indicators of the geopolitical contacts of the royal families of Sak Chuwen of Naranjo and Chak Tok Wayaab of Holmul, including changes in polychrome pottery and hieroglyphic inscriptions, in particular, rhetoric of good governance and political loyalty. In the case of Holmul, the transformation affects the urban landscape of the site. New data clarify the relationship between Holmul and Naranjo during the initial period of their subordination to the kings of Dzibanche. The emerging picture of these secondary alliances and hierarchies within the Kaanu'l domain is essential for a better understanding of Classic Maya political systems at local and regional levels.
Impact of high-flow nasal oxygen therapy on postoperative atelectasis and reintubation rate after paediatric cardiac surgery
Authors: Öztürk Erkut , Ozyilmaz Isa , Yücel Ezgi Direnç , Recep Berra Zümrüt Tan , Tanidir İbrahim Cansaran , Hatemi Ali Can 
Published: October 2024

AbstractIntroduction:Airway problems emerging after congenital cardiac surgery operations may have an impact on mortality and morbidity. Recently, to improve alveolar gas exchange and reduce respiratory effort, high-flow nasal cannula (HFNC) has started to be used in paediatric cases. This study aimed to evaluate the potential effects of high-flow nasal oxygen therapy on postoperative atelectasis development and reintubation rate in paediatric cardiac surgery patients.Methods:This study was conducted retrospectively in term newborns and infants younger than six months of age who underwent congenital cardiac surgery operation from 1 November 2022 to 1 November 2023 and were followed in the paediatric cardiac ICU. Patients who were receiving mechanical ventilator support at least 12 hours postoperatively were evaluated for the development of postoperative atelectasis and reintubation in the first 3 days of extubation. The patients were grouped as HFNC and non-HFNC users. Demographic characteristics, surgery type, and ICU clinical follow-up data were obtained from medical records. The results were statistically evaluated.Results:A total of 40 patients who did not use HFNC in the early postoperative period and 40 patients with HFNC in the late period during the study period were included in the study. The median age was 1 month (IQR 15 days–2 months) with equal gender distribution. Among patients, 70% of them were in the neonatal age group. Reintubation rates in the first 72 hours in HFNC users and non-HFNC users were 2.5% and 12.5%, respectively (p < 0.05). The median postoperative atelectasis scores at 24, 48, and 72 hours of extubation were 2 versus 2.5 (p > 0.05), 1.5 versus 3.5 (p < 0.05), and 1 versus 3 (p < 0.05) in HFNC users and non-HFNC users, respectively.Conclusion:HFNC therapy may have a positive effect on preventing atelectasis and reducing the reintubation rate in the early postoperative period.
Myocardial infarction in a 17-year-old patient diagnosed with MPOD II syndrome
Authors: Clarac Cécilia , Karila-Cohen Julie , Bonnet Damien 
Published: October 2024

AbstractIntroduction:Microcephalic osteodysplastic primordial dwarfism (MOPD) syndrome type 2, caused by a mutation in the PCNT gene (21q22.3), is a rare autosomal recessive disorder. Patients present with bone dysplasia, insulin resistance, kidney diseases, and cardiac malformations, making them prone to vascular diseases. Cardiomyopathy, hypertension, and coronary diseases are documented. The prognosis is associated with cerebrovascular complications.Method:We report a case of a patient with MOPD type II who suffered a myocardial infarction in our institution. Informed consent for publishing was obtained.Result:A 17-year-old female with MPOD II syndrome (20 kg and 86 cm) was referred for chest pain. Thoracic pains had been occurring for over a month, increasing in intensity, with an episode prompting emergency consultation. Initial tests revealed elevated troponin and an inflammatory response. Electrocardiogram (ECG) showed ST-segment depression and elevation. Echocardiography revealed hypokinetic inferior walls with moderate concentric hypertrophy. A coronary CT scan showed subendocardial hypodensity. Diagnostic coronary angiography revealed tri-branch lesions and almost complete stenoses or occlusions on the circumflex artery (Image). No indication for interventional treatment due to diffuse atheromatous lesions. Exclusive medical treatment was initiated.Conclusion:MPOD II syndrome is associated with cardiac malformations and neurovascular complications, including myocardial infarction. Regular ECG monitoring is advisable. Active surveillance for coronary diseases is necessary from adolescence. Recognising this complication allows for prompt intervention. This case highlights the need for specific monitoring and prompt management of chest pain in patients with MPOD II syndrome. Primary prevention could mitigate the occurrence of coronary events in this high-risk population.
Team dynamics after implementation of guidelines for anaesthesia for children with CHD
Authors: Vogt Peggy , Libby Julie , Long Justin B. 
Published: October 2024

AbstractGuidelines were created at our single centrer institution for which anesthesiology team should care for pediatric cardiac patients for noncardiac surgery. The goal of the survey was to assess inter-team dynamics after the implementation of guidelines and revealed that practice behaviour can quickly change but a sustained change in team dynamics and workplace culture takes time.
Factors associated with caregiver strain among mothers and fathers of children with advanced cancer
Authors: Olsavsky Anna L. , Sutherland-Foggio Malcolm , Stanek Charis J. , Hill Kylie N. , Himelhoch Alexandra C. , Kenney Ansley E. , Humphrey Lisa , Olshefski Randal , Skeens Micah A. , Nahata Leena , Gerhardt Cynthia A. 
Published: October 2024

AbstractObjectivesTo characterize caregiver experiences in the context of advanced pediatric cancer by identifying individual (i.e., demographic factors, stress) and family context factors (i.e., family roles, social support) associated with caregiver strain.MethodsFamilies of children (ages 5–25) with advanced cancer (i.e., physician-estimated prognosis < 60%, relapsed/refractory disease) were recruited from a large children’s hospital. Mothers (n = 55; 87% White) and fathers (n = 30; 83% White) reported on their caregiver strain, cancer-specific stress, general stress, social support, division of 7 family roles (e.g., medical care of ill child, household chores), and their satisfaction with each role.ResultsParents reported moderate caregiver strain, cancer-specific stress, and general stress, and high social support and satisfaction with family roles. Fathers reported family roles were shared equally, whereas mothers reported either sharing roles or completing them independently. When accounting for income and partnership status, greater caregiver strain for mothers was associated with greater general stress, greater satisfaction with family roles, and lower social support. For fathers, greater caregiver strain was associated only with greater cancer-specific stress.Significance of resultsIn the context of advanced pediatric cancer, fathers may experience caregiver strain as cancer-specific stress increases, whereas mothers’ strain may depend on broader family and social factors. Psychosocial providers should address general and cancer-specific stress within families, and provide resources for enhancing mothers’ social support. Additional research is needed with larger, more diverse samples to inform future intervention approaches.
Landslide Hazard Is Projected to Increase Across High Mountain Asia
Authors: Stanley Thomas A. , Soobitsky Rachel B. , Amatya Pukar M. , Kirschbaum Dalia B. 
Published: October 2024

AbstractHigh Mountain Asia has long been known as a hotspot for landslide risk, and studies have suggested that landslide hazard is likely to increase in this region over the coming decades. Extreme precipitation may become more frequent, with a nonlinear response relative to increasing global temperatures. However, these changes are geographically varied. This article maps probable changes to landslide hazard, as shown by a landslide hazard indicator (LHI) derived from downscaled precipitation and temperature. In order to capture the nonlinear response of slopes to extreme precipitation, a simple machine‐learning model was trained on a database of landslides across High Mountain Asia to develop a regional LHI. This model was applied to statistically downscaled data from the 30 members of the Seamless System for Prediction and Earth System Research large ensembles to produce a range of possible outcomes under the Shared Socioeconomic Pathways 2‐4.5 and 5‐8.5. The LHI reveals that landslide hazard will increase in most parts of High Mountain Asia. Absolute increases will be highest in already hazardous areas such as the Central Himalaya, but relative change is greatest on the Tibetan Plateau. Even in regions where landslide hazard declines by year 2100, it will increase prior to the mid‐century mark. However, the seasonal cycle of landslide occurrence will not change greatly across High Mountain Asia. Although substantial uncertainty remains in these projections, the overall direction of change seems reliable. These findings highlight the importance of continued analysis to inform disaster risk reduction strategies for stakeholders across High Mountain Asia.