bluuebunny/crossref_metadata_2025_split huggingface dataset:
INITIAL AND RECOVERY HEAT PRODUCTION IN SMOOTH MUSCLE BASED UPON EXPERIMENTS ON A URINARY BLADDER-NERVE PREPARATION FROM TERRAPIN
Authors: Snyder C. D. , Light F. W. 
Published: December 2017

[ To be inserted by the binder in Volume 86, no. 2, of This Journal, and between pages 398 and 399.] 1. On page 399 add to the name of the co-author, "F. W. Light. Jr.," an asterisk, and at the bottom of the page add this footnote: "* Aided by a grant from The Henry Strong Denison Medical Foundation." 2. On page 414 in the first line of the legend change "iv" to "vi." 3. On page 417 in the seventh line from the bottom change the figure, "22.2" to "37.3."
THE INFLUENCE OF FREQUENCY OF CONTRACTION OF THE ISOLATED MAMMALIAN HEART UPON THE CONSUMPTION OF OXYGEN
Authors: Cohn A. E. , Steele J. Murray 
Published: December 2017

On page 654 (3 lines from bottom) for (cf. 3. Table 111, p. 259) read (cf. Table III, p. 259). On page 655 (first line) for (Table 4, p. 259) (3) read (Table IV, p. 259) ( 5).
On comparing regression lines with unequal slopes
Authors: Zerbe Gary O. , Archer Philip G. , Banchero Natalio , Lechner Andrew J. 
Published: December 2017

Page R178: Gary O. Zerbe, Philip G. Archer, Natalio Banchero, and Andrew J. Lechner. “On comparing regression lines with unequal slopes.” Page R179: first column, the paragraph after Equation 7 should read Case II. If A < 0 and D > 0, then the tests will be significant for X's satisfying (See PDF)
Cerebral metabolic responses and vasopressin and oxytocin secretions during progressive water deprivation in rats
Authors: Kadekaro M. , Summy-Long J. Y. , Freeman S. , Harris J. S. , Terrell M. L. , Eisenberg H. M. 
Published: December 2017

Pages R310–R317: M. Kadekaro, J. Y. Summy-Long, S. Freeman, J. S. Harris, M. L. Terrell, and H. M. Eisenberg. “Cerebral metabolic responses and vasopressin and oxytocin secretions during progressive water deprivation in rats.” Page R314: In several places in Table 6 the word “nerve” was incorrectly substituted for the word “nucleus.” The correct table appears below. (See PDF)
Gastric branch vagotomy blocks nutrient and cholecystokinin-induced suppression of gastric emptying
Authors: Schwartz G. J. , Berkow G. , McHugh P. R. , Moran T. H. 
Published: December 2017

Pages R630–R637: G. J. Schwartz, G. Berkow, P. R. McHugh, and T. H. Moran. “Gastric branch vagotomy blocks nutrient and cholecystokinin-induced suppression of gastric emptying.” Page R361: An incorrect formula was used to calculate the volume remaining. The correct formula appears below. V = (Cs/Ci){[5/(1 – Co/Cs)] – 5} where Cs, is the concentration of dye in the stomach before saline rinse. The other factors remain as described in the article. This error resulted in a small underestimation of the magnitude of the reported phenomena in a few cases and does not alter the main findings, conclusions, or interpretations of this study.
Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity
Authors: Engelke K. A. , Doerr D. F. , Convertino V. A. 
Published: December 2017

Pages R837–R847: K. A. Engelke, D. F. Doerr, and V. A. Convertino. “Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity.” On p. 837, the author line of the article and abstract and the affiliation line should read as follows: KEITH A. ENGELKE, DONALD F. DOERR,CRAIG G. CRANDALL, AND VICTOR A. CONVERTINO Department of Physiology, University of Florida, Gainesville, Florida 32610; National Aeronautics and Space Administration-Kennedy Space Center, Cape Canaveral, Florida 32899;Department of Physiology, University of North Texas Health Science Center, Ft. Worth, Texas 76107; and Physiology Research Branch, Clinical Science Division, Brooks Air Force Base, Texas 78235
Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity
Authors: Engelke K. A. , Doerr D. F. , Convertino V. A. 
Published: December 2017

Pages R837–R847: K. A. Engelke, D. F. Doerr, and V. A. Convertino. “Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity.” On p. 837, the author line of the article and abstract and the affiliation line should read as follows: KEITH A. ENGELKE, DONALD F. DOERR, CRAIG G. CRANDALL, AND VICTOR A. CONVERTINO Department of Physiology, University of Florida, Gainesville, Florida 32610; National Aeronautics and Space Administration-Kennedy Space Center, Cape Canaveral, Florida 32899; Department of Physiology, University of North Texas Health Science Center, Ft. Worth, Texas 76107; and Physiology Research Branch, Clinical Science Division, Brooks Air Force Base, Texas 78235
Motility studies of isolated antral pouches before and after vagus denervation
Authors: Wohlrabe Donald E. , Kelly William D. 
Published: December 2017

The motility responses of vagus innervated and denervated antral pouches to electrical stimulation of the vagus nerves and to insulin hypoglycemia were determined. Electrical stimulation appears to be a reliable method of demonstrating the presence or absence of vagus nerve supply to the antrum both in acute studies and in preparations of several months' duration. The motility response of the antral pouch to insulin hypoglycemia was found to be a less reliable method of determining the presence or absence of vagal innervation largely because spontaneous hypermotility may occur and there is more room for difference of opinion in interpretation of the results obtained. The administration of glucose after an appropriate time interval, however, added significantly to the reliability of the test. By the methods employed the antral branches of the vagus nerves were found to be the only sources of vagus innervation of the antrum. No evidence was obtained to suggest effective parasympathetic innervation of the antrum via a pyloric nerve, via the greater curvature mesenteric attachment or via an intramural gastric pathway. Submitted on July 7, 1958
Esophageal and pleural pressures in man, upright and supine
Authors: Mead Jere , Gaensler E. A. 
Published: December 2017

To assess the reliability of esophageal sampling of pleural pressure, both pressures were recorded simultaneously in seven subjects in the upright posture and, in five of these, in the supine posture. Esophageal pressure was obtained with air-containing latex balloons and pleural pressure was recorded from catheters introduced into the intrapleural space. Pneumothorax volumes were estimated to be between 5 and 350 ml. The closest correspondence between the pressures was observed in the upright posture. Expressing the difference in the amplitude of the respiratory excursions as the percentage of deviation of esophageal from pleural pressures, in the upright posture individual values ranged from +20 to -18, while the average value for the group did not differ significantly from 0. On the other hand, in the supine position individual variation was greater (range +60 to -25) and, on the average, esophageal pressure amplitudes were larger (average +27 during quiet breathing) than pleural pressure amplitudes. Submitted on August 22, 1958
Combined ventilatory and breath-holding evaluation of sensitivity to respiratory gases
Authors: Stroud Robert C. 
Published: December 2017

Direct measurements of the ventilatory response to variations in CO2 tension independent of changes in O2 tension are easily obtained by breathing mixtures of carbon dioxide in 100% oxygen. Direct determination of the respiratory response to O2, however, is not possible due to alternations in CO2 tension resulting from changes in ventilation. Therefore, an attempt has been made to determine this response empirically by a combined analysis of breath-holding and ventilatory data. Comparison of experimentally determined responses to various combinations of O2 and CO2 tensions agree quite well with those predicted by this approach and indicate that oxygen plays a small but definite role in the regulation of eupnic breathing at sea level. Submitted on October 22, 1958
Extreme warmth and sensorimotor coordination
Authors: Pepler R. D. 
Published: December 2017

Six subjects were exposed for 30 minutes on three occasions at 48-hour intervals to a very warm, humid climate with a wet bulb temperature of 105℉ (41℃). During the second and third exposures the subjects worked continuously to keep a pointer aligned with a target mark, as it moved erratically from side to side. Accuracy of alignment was normal at first, but deteriorated rapidly and progressively. Movement of the pointer was greater than usual right from the start and changed little thereafter. Rectal temperature rose steadily during the exposures. Failures to correct progressively greater misalignments of the pointer were thought to indicate a growing inattentiveness to the task and a general deterioration in the organization of performance. Submitted on September 2, 1958
Effects of oral glycine during cold exposure in man
Authors: Beavers William R. , Covino Benjamin G. 
Published: December 2017

Six male human subjects were given 30 gm oral glycine. Oxygen consumption, skin and rectal temperatures, and forefinger blood flows were measured during an interval in a warm room and then during 75 minutes cold exposure (0°F). The same subjects receiving 30 gm glucose served as controls. Glycine increased heat production at rest in a warm room and also during cold exposure. The subjects when receiving glycine had a slightly higher rectal temperature and higher skin temperatures in areas other than fingers during the cold exposure period. Submitted on August 1, 1958
Effect of restraint on altitude tolerance in the rat
Authors: Bartlett R. G. , Altland P. D. 
Published: December 2017

Young adult male and female Sprague-Dawley rats were exposed to a simulated altitude of 33,500 ft. both with and without restraint. The exposure was begun immediately upon the restraint of the experimental animals. The restrained animals died significantly sooner than did the nonrestrained controls. The possible relation of colonic temperature, oxygen consumption and emotional stress to the decreased altitude tolerance is discussed. It is suggested that the data serve as a warning for caution in the use of restraint for convenience in altitude tolerance experiments. Submitted on August 6, 1958
EEG amplitude and reaction time during sleep
Authors: Coleman Paul D. , Gray Florence E. , Watanabe Kyozo 
Published: December 2017

Amplitude of the electroencephalogram was evaluated as a measure of sleep. EEG amplitude during sleep was found to be a) significantly and positively correlated with reaction time, b) inversely related to the duration of periods during which no gross body movement occurred and c) only slightly negatively related to heart rate. Submitted on August 11, 1958
Distribution of fluoride in the normal dog femur
Authors: Gardner Dwight E. , Smith Frank A. , Hodge Harold C. , Brudevold Finn , Eldredge Donald McG. 
Published: December 2017

Longitudinal sections and concentric layers of normal dog femurs were analyzed for their fluoride contents. Longitudinally, fluoride is deposited in greatest concentrations in the epiphyseal regions, i.e. the regions of vascularity and active growth. Concentrations in these regions are approximately twofold greater than at the mid-point of the diaphysis. In cross section, fluoride is also deposited in greater concentrations in the areas of more rapid growth and better blood supply, i.e. on the periosteal and endosteal surfaces of the shaft. The pattern of deposition is similar in adult and young bone, though fluoride concentrations are appreciably greater in the adult bone. The pattern of distribution conforms with the accepted principles of deposition of other boneseeking elements. Submitted on November 17, 1958
Solubility of inert gases in human lung tissue
Authors: Cander Leon 
Published: December 2017

Solubilities of the relatively insoluble inert gases, sulfur hexafluoride (SF6) and helium (He), the moderately soluble inert gases, nitrous oxide (N2O) and acetylene (C2H2), and the very soluble inert gas, diethyl ether, were determined in blood-free homogenates of human lung tissue at 37℃ by techniques employing the manometric and volumetric van Slyke apparatuses. The values, reported as Bunsen solubility coefficients at 37℃, were 0.0068, 0.0092, 0.407, 0.768 and 13.4 for SF6, He, N2O, C2H2 and diethyl ether, respectively. Submitted on December 4, 1958
Factor X phenomenon
Authors: Spaet Theodore H. , Kropatkin Mona 
Published: December 2017

Storage of human serum at refrigerator temperature yields a reagent which poorly supports thromboplastin generation. Although the degree of this defect showed no correlation with the serum prothrombin content, a high serum prothrombin was found to preserve activity. The clotting defect in stored serum was shown to be different from that in Stuart factor-deficient serum, as determined by mixing studies in both prothrombin and thromboplastin generation procedures. It is concluded that the factor X phenomenon is unique, although these studies do not establish factor X as a chemical entity. Submitted on November 28, 1958
Physical fitness of oarsmen and rugby players before and after training
Authors: Sloan A. W. , Keen E. N. 
Published: December 2017

Resting pulse rates and fitness indexes by the Harvard step test were ascertained in 100 healthy male University students. The subjects included members of the University rowing and rugby clubs, who were about to undergo systematic training, and a third group of students not engaged in any such activity. The observations were repeated on 58 of the students after a period of 2–4 months. The mean resting pulse rates of the three groups were not originally significantly different but after training the pulse rate was significantly lower in the athletic groups than in the controls. At the beginning of the training period the oarsmen and rugby players already had higher fitness indexes than the controls and thereafter they showed significant improvement with training. A significant negative correlation between resting pulse rate and fitness index was found only in the athletic groups. Submitted on October 16, 1958
Pulmonary surface tension
Authors: Brown Elwyn S. , Johnson Rudolph P. , Clements John A. 
Published: December 2017

The surface tension of the lung decreases markedly on compression resulting from deflation, as calculated from P-V data, and follows a force-area path very similar to that of several mucus surfaces. With changes in surface area of less than 50%, lung extract and mucus bubble surfaces are mechanically reversible. For decrease in area greater than 50%, surface tension approaches a lower limiting tension of 10–15 d/cm. On re-expansion of the surface, an upper limiting tension of 40–50 d/cm is approached. Hysteresis of considerable magnitude occurs and indicates a major alteration of the surface materials compressed beyond 50%. Estimates of lung surface area based on these considerations accord with histologic estimates. Submitted on December 4, 1958
Evaluation of use of left coronary artery inflow and O2 content of coronary sinus blood as a measure of left ventricular metabolism
Authors: Rayford C. R. , Khouri E. M. , Lewis F. B. , Gregg D. E. 
Published: December 2017

Experiments reported here show that the coronary sinus blood is derived almost entirely from the left coronary artery inflow and is not significantly contaminated with blood from other myocardial territories. The special cannula used for cannulating the coronary sinus permits drainage of all veins which empty into the coronary sinus. In consequence, the percentage of left coronary artery inflow recovered in the coronary sinus is high (usually 80–90%) and reasonably constant during changes in coronary perfusion pressure, aortic constriction, administration of epinephrine or norepinephrine, hemorrhage and reinfusion, induced ventricular fibrillation, and pulmonary artery constriction. The use of the arteriovenous oxygen difference between the arterial and coronary sinus blood in combination with left coronary artery inflow as a precise measure of left ventricular metabolism is validated under these experimental conditions. Submitted on January 29, 1959
Role of ferritin in nutritional edema
Authors: Srikantia S. G. , Gopalan C. 
Published: December 2017

The sequence of changes that occur in induced protein malnutrition has been studied in nine monkeys, three of which received an aureomycin supplement of 25 mg/kg per day from the first day of the experimental period. Serial estimations of serum protein and albumin levels, response to water load, thiocyanate space and the presence of active ferritin in circulation were determined in all nine monkeys. All the monkeys developed edema between the 13th and 16th week of the experiment, except two of the three aureomycin-supplemented animals. While no correlation was observed between serum albumin levels or impairment of response to water load on the one hand and edema on the other, there was a striking relationship between the appearance of active ferritin in circulation and the subsequent formation of edema. The increase in thiocyanate space was invariably preceded by the presence of ferritin in the blood. During nutritional rehabilitation, ferritin disappeared from circulation before the thiocyanate space returned to normal levels. It is significant that aureomycin, which prevented the appearance of ferritin in the blood, also prevented the development of edema. The results of the investigation strongly suggest a causal relationship between ferritin and nutritional edema. Submitted on August 13, 1958
O2 diffusion in lung of the anesthetized cat
Authors: Duke Helen N. , Stedeford R. D. 
Published: December 2017

In cats under chloralose anesthesia, the mean diffusing capacity for O2 (Do2) was 0.91 (S.D. ± 0.29). The mean Do2/m2 body surface was 3.26 (S.D. ± 1.30). Under the experimental conditions described, the Do2 was linearly related to the O2 consumption/body weight or surface area of the animal. The Do2 was reduced by bronchial occlusion in approximate proportion to the blocked area. Cooling the animal also reduced the Do2. Epinephrine and 5-hydroxytryptamine given by constant intravenous infusion had slight effects on the Do2. Dissociation curves for cats' blood are reported. Submitted on December 5, 1958
Circulating plasma volume changes in anesthetized dogs during positive pressure breathing
Authors: Sobel S. , Marotta S. F. , Marbarger J. P. 
Published: December 2017

Various circulatory functions were measured in anesthetized dogs subjected to 18.5 mm Hg positive pressure breathing. Immediately upon raising the intrapulmonary pressure there occurred a five- to sixfold increase in venous pressure as well as a decrease in mean arterial pressure. Accompanying these pressure changes was a progressive decrease in circulating plasma volume as measured by the T-1824 method. A 30% decrease in plasma volume was recorded after 160 minutes of increased intrapulmonary pressure. Hemoconcentration was also indicated by the increased hematocrits, although calculated fluid loss was only 13%. All circulatory changes returned to prepressure breathing levels upon release of pressure breathing. Other changes, such as oliguria, periods of apnea and an alkaline urine accompanied positive pressure breathing. The data suggest that the decrease in plasma volume is the result of venostasis caused by the rapid increase in venous pressure. Submitted on April 27, 1959
Respiratory and cerebral circulatory control during exercise at .21 and 2.0 atmospheres inspired pO2
Authors: Lambertsen Christian J. , Owen S. G. , Wendel Herbert , Stroud Morris W. , Lurie Abraham A. , Lochner Wilhelm , Clark Gordon F. 
Published: December 2017

Respiratory and cerebral hemodynamic responses to leg exercise during respiration of air at 1.0 atm. and O2 at 2.0 atm. were studied in relation to changes in arterial and internal jugular venous blood oxygen composition, pH, pCO2 and bicarbonate concentration. The hyperpnea of exercise at 1.0 atm. was accompanied by arterial and venous acidemia and hypocapnia. Oxygen administration during exercise at 2.0 atm. lowered ventilation, restored arterial pH and pCO2 toward resting levels and caused venous pCO2 to rise above the resting level; cerebral venous cH remained elevated in spite of reduction of blood fixed acid concentration. The ventilatory response to exercise showed positive correlations with work load, oxygen consumption, and with changes in arterial and internal jugular venous cH and fixed acid. The observed negative correlations of changes in respiratory minute volume with changes in arterial and internal jugular venous pCO2 and bicarbonate concentration suggest that these factors are functions, rather than primary determinants, of ventilation in exercise. Cerebral hemodynamics and oxygen consumption were not significantly altered by exercise at 1.0 atm. The data suggest either a slight elevation of cerebral blood flow or reduction in the rate of cerebral oxygen consumption during exercise breathing O2 at 2.0 atm., without gross elevation of cerebral venous pO2. Observed changes in cerebral vascular resistance during exercise at .21 and 2.0 atm. inspired pO2 appear related to concomitant alterations in arterial pCO2, with no detectable relationship either to brain oxygen requirement of cerebral venous acid-base composition. Submitted on November 25, 1958
Effect of environmental temperature on metabolic changes following physical injury
Authors: Haist R. E. , Hawkins Rosemary D. , Kovacs Georgine V. 
Published: December 2017

Rats in shock resulting from limb ischemia showed no significant differences in the rise in blood nonprotein nitrogen when kept at different environmental temperatures after the period of limb ischemia. Under these conditions the elevation in blood inorganic phosphorus was inversely related to the environmental temperature. In the shocked rats the tolerance for orally administered carbohydrate was less and the hepatic glycogen values were higher at 21°-32°C than at 10°C. However, at similar times the residue of reducing substances in the gut was greater at 10°C than at 21°-32°C. There was no significant difference in the tolerance for intravenously administered glucose at 10°, 20° and 30°C in the shocked rats, but control rats, with clamps left in position, showed a significantly better tolerance at 10°C than at 20° or 30°C. Under the conditions used, environmental temperature had little influence on blood N.P.N. changes in shock, but did influence the blood inorganic phosphorus levels and the tolerance for orally administered carbohydrate. Submitted on July 16, 1959
Correlation of pulmonary function and domestic microenvironment
Authors: Shephard Roy J. , Turner M. E. , Carey G. C. R. , Phair J. J. 
Published: December 2017

Pulmonary pressures, total and timed vital capacity, functional residual capacity and carbon monoxide uptake have been correlated with temperature, humidity, suspended particulate matter and gaseous acid in a 3-month prospective survey of 10 cardiorespiratory cripples. Results have been analyzed by a sequential multiple regression technique, and significant relationships demonstrated between pulmonary function measurements and time, humidity and suspended particulate matter. The immediate response to suspended particulate matter was consistent with bronchoconstriction, although the most significant features were a transient depression of pulmonary pressures and carbon monoxide uptake. The prolonged depression of carbon monoxide uptake, starting 4 days after an intense episode of pollution, did not show itself as a significant long-lag coefficient for the survey as a whole; the existence of a threshold dose of suspended particulate to produce structural damage is postulated. Submitted on February 20, 1959