bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potential for chemotherapy-free strategies in mantle cell lymphoma
Authors: Martin Peter , Ruan Jia , Leonard John P. 
Published: September 2017

Abstract
Mantle cell lymphoma (MCL) may be 1 of the few cancers for which multiple chemotherapy and nonchemotherapy regimens are considered as standard. Despite the significant activity of chemotherapy in the first-line setting and beyond, its limitations are reflected in the relatively poor ultimate outcomes of patients with MCL treated in the real world. Patients with highly proliferative MCL and those with TP53 mutations tend to respond poorly despite intensive cytotoxic therapies. Patients with comorbidities and those who are geographically isolated may not have access to the regimens that may appear most promising in clinical trials. Thoughtfully directed, nonchemotherapy agents might overcome some of the factors associated with a poor prognosis, such at TP53 mutation, and might resolve some of the challenges related to the toxicity and deliverability of standard chemotherapy regimens. Several clinical trials have already demonstrated that combinations of nonchemotherapy plus chemotherapy drugs can impact outcomes, whereas data with nonchemotherapy agents alone or in combination have suggested that some patients might be well suited to treatment without chemotherapy at all. However, challenges including chronic or unexpected toxicities, the rational vs practical development of combinations, and the financial acceptability of new strategies abound. The nonchemotherapy era is here: how it unfolds will depend on how we meet these challenges.
Bronchial hyperresponsiveness and obesity in middle age: insights from an Australian cohort
Authors: Burgess John A. , Matheson Melanie C. , Diao Fei , Johns David P. , Erbas Bircan , Lowe Adrian J. , Gurrin Lyle C. , Lodge Caroline J. , Thomas Paul S. , Morrison Stephen , Thompson Bruce R. , Feather Iain , Perret Jennifer L. , Abramson Michael J. , Giles Graham G. , Hopper John L. , Dharmage Shyamali C. , Walters Eugene H. 
Published: September 2017

The association between obesity and bronchial hyperresponsiveness (BHR) is incompletely characterised. Using the 2006 follow-up of the Tasmanian Longitudinal Health Study, we measured the association between obesity and BHR and whether it was mediated by small airway closure or modified by asthma and sex of the patient.A methacholine challenge measured BHR. Multivariable logistic regression measured associations between body mass index (BMI) and BHR, adjusting for sex, asthma, smoking, corticosteroid use, family history and lung function. Mediation by airway closure was also measured.Each increase in BMI of 1 kg·m−2was associated with a 5% increase in the odds of BHR (OR 1.05, 95% CI 1.01–1.09) and 43% of this association was mediated by airway closure. In a multivariable model, BMI (OR 1.06, 95% CI 1.00–1.16) was associated with BHR independent of female sex (OR 3.26, 95% CI 1.95–5.45), atopy (OR 2.30, 95% CI 1.34–3.94), current asthma (OR 5.74, 95% CI 2.79–11.82), remitted asthma (OR 2.35, 95% CI 1.27–4.35), low socioeconomic status (OR 2.11, 95% CI 1.03–4.31) and forced expiratory volume in 1 s/forced vital capacity (OR 0.86, 95% CI 0.82–0.91). Asthma modified the association with an increasing probability of BHR as BMI increased, only in those with no or remitted asthma.An important fraction of the BMI/BHR association was mediatedviaairway closure. Conflicting findings in previous studies could be explained by failure to consider this intermediate step.
Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Retrospective Analysis
Authors: Matutino Adriana , Mak Milena P. , Takahashi Tiago K. , Bitton Rafael C. , Nakazato Denyei , Fraile Natalia M.P. , Guimarães Roger G.R. , Gabrielli Flávia C.G. , Vasconcelos Karina G.M.C. , Carvalho Heloísa de A. , de Castro Gilberto 
Published: September 2017

Purpose Extensive-stage small-cell lung cancer (esSCLC) is an incurable disease and represents a therapeutic challenge because of its poor prognosis. Studies in prophylactic cranial irradiation (PCI) in esSCLC have shown a decreased incidence of symptomatic brain metastases in patients who respond to systemic chemotherapy. However, its effect on overall survival is debatable. We evaluated the benefit of PCI in patients with esSCLC in terms of overall survival, progression-free survival, incidence of brain metastases, recurrence rate, and exposure to postrecurrence therapies. Materials and Methods We retrospectively reviewed electronic charts from patients diagnosed with esSCLC from 2008 to 2014 at our institution. All patients had negative baseline brain imaging before chemotherapy and PCI and received at least 4 cycles of platinum-based chemotherapy in the first-line setting without progressive disease on follow-up. PCI was performed at the discretion of the treating physician. Analyses were based on descriptive statistics. Survival curves were calculated by Kaplan-Meier method. Results Among 46 eligible patients, 16 (35%) received PCI and 30 (65%) did not. Compared with no PCI, PCI led to improved progression-free survival (median, 10.32 v 7.66 months; hazard ratio, 0.4521; 95% CI, 0.2481 to 0.8237; P < .001) and overall survival (median, 20.94 v 11.05 months; hazard ratio, 0.2655; 95% CI, 0.1420 to 0.4964; P < .001) as well as lower incidence of brain metastases (19% v 53%; P = .0273) and higher exposure to second-line chemotherapy (87% v 57%; P = .0479). Conclusion Careful patient selection for PCI can improve not only brain metastases control and higher second-line chemotherapy exposure but also patient survival.
Dexmedetomidine Maintains Its Direct Cardioprotective Effect Against Ischemia/Reperfusion Injury in Hypertensive Hypertrophied Myocardium
Authors: Yoshikawa Yusuke , Hirata Naoyuki , Kawaguchi Ryoichi , Tokinaga Yasuyuki , Yamakage Michiaki 
Published: September 2017

BACKGROUND:
Dexmedetomidine (DEX) has a direct cardioprotective effect against ischemia/reperfusion injury through endothelial nitric oxide synthase (eNOS) phosphorylation via α2-adrenoreceptor (α2-AR). By using spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rat models, the cardioprotective effect of DEX in hypertrophied myocardium and the differential characteristics of cardiac α2-AR and the I1 imidazoline receptor (I1R) were examined.

METHODS:
Langendorff-perfused rat hearts underwent 40 minutes of global ischemia followed by 120 minutes of reperfusion in the presence or absence of DEX before ischemia. Infarct size was measured, and eNOS phosphorylation was assessed by Western blotting. The presence and expression of the receptors were assessed by immunohistochemistry, real-time reverse transcriptase polymerase chain reaction, and Western blotting.

RESULTS:
In WKY, DEX significantly decreased infarct size and increased phosphorylated-eNOS/eNOS. These effects were counteracted by yohimbine (α2-AR antagonist) and efaroxan (α2-AR and I1R antagonist). In SHR, DEX significantly decreased infarct size, and the effect was counteracted by efaroxan but not yohimbine. DEX did not alter phosphorylated-eNOS/eNOS in SHR. α2-AR and I1R were observed in WKY and SHR hearts. Although alpha2A-AR and alpha2B-AR messenger RNA and protein levels were upregulated in SHR, I1R expression was comparable between the 2 species.

CONCLUSIONS:
In the hypertrophied heart, DEX maintains its direct cardioprotective effect against ischemia/reperfusion injury via I1R in an eNOS-nondependent manner despite upregulation of α2-AR.
A new species of Ianthorntonia García Aldrete, from Bolivia, and description of the female Ianthorntonia marshalli García Aldrete (Psocodea: Psocomorpha: Epipsocetae: Epipsocidae)
Authors: García Aldrete Alfonso Neri 
Published: September 2017

Abstract. A species of Ianthorntonia García Aldrete from the Department of La Paz, Bolivia, is here described and illustrated. It is based on a male, and differs from the other five species in the genus on hypandrium and phallosome characters. Also, the female Ianthorntonia marshalli García Aldrete, 2004, collected at the type locality of the species, is described and illustrated. It is the first female known in the genus; as expected, it is similar to the females of Goja Navás and Gojaoides García Aldrete.Uma nova espécie de Ianthorntonia García Aldrete, para a Bolívia, e descrição da fêmea de Ianthorntonia marshalli García Aldrete (Psocodea: Psocomorpha: Epipsocetae: Epipsocidae)Resumo. Uma espécie de Ianthorntonia García Aldrete, proveniente do departamento de La Paz, Bolívia, é aqui descrita e ilustrada. Esta espécie é baseada em um macho e difere das outras cinco espécies deste gênero pelas características do hipândrio e do falossomo. Além disso, a fêmea de Ianthorntonia marshalli García Aldrete, 2004, coletada na localidade tipo desta espécie, é descrita e ilustrada. Esta é a primeira fêmea conhecida para este gênero; como previsto, ela é similar as fêmeas de Goja Navás e Gojaoides García Aldrete.
Appropriate Reconciliation of Cardiovascular Medications After Elective Surgery and Postdischarge Acute Hospital and Ambulatory Visits
Authors: Lee Jonathan S. , Gonzales Ralph , Vittinghoff Eric , Corbett Kitty K. , Fleischmann Kirsten E. , Sehgal Neil , Auerbach Andrew D. 
Published: September 2017

BACKGROUNDFew studies have assessed the quality and impact of postoperative cardiovascular medication reconciliation.OBJECTIVETo describe appropriate discharge reconciliation of cardiovascular medications and assess associations with postdischarge healthcare utilization in surgical patients.DESIGNRetrospective cohort study from January 2007 to December 2011.SETTINGAn academic medical center.PATIENTSSeven hundred and fifty‐two adults undergoing elective noncardiac surgery and taking antiplatelet agents, beta‐blockers, renin‐angiotensin system inhibitors, or statin lipid‐lowering agents before surgery.MEASUREMENTSPrimary predictor: appropriate discharge reconciliation of preoperative cardiovascular medications (continuation without documented contraindications). Primary outcomes: acute hospital visits (emergency department visits or hospitalizations) and unplanned ambulatory visits (primary care or surgical) at 30 days after surgery.RESULTSPreoperative medications were appropriately reconciled in 436 (58.0%) patients. For individual medications, appropriate discharge reconciliation occurred for 156 of the 327 patients on antiplatelet agents (47.7%), 507 of the 624 patients on beta‐blockers (81.3%), 259 of the 361 patients on renin‐angiotensin system inhibitors (71.8%), and 302 of the 406 patients on statins (74.4%). In multivariable analyses, appropriate reconciliation of all preoperative medications was not associated with acute hospital (adjusted odds ratio [AOR], 0.94; 95% confidence interval [CI], 0.63‐1.41) or unplanned ambulatory visits (AOR, 1.48; 95% CI, 0.94‐2.35). Appropriate reconciliation of statin therapy was associated with lower odds of acute hospital visits (AOR, 0.47; 95% CI, 0.26‐0.85). There were no other statistically significant associations between appropriate reconciliation of individual medications and either outcome.CONCLUSIONSAlthough large gaps in appropriate discharge reconciliation of chronic cardiovascular medications were common in patients undergoing elective surgery, these gaps were not consistently associated with postdischarge acute hospital or ambulatory visits.
Release of the tourniquet immediately after the implantation of the components reduces the incidence of deep vein thrombosis after primary total knee arthroplasty
Authors: Zan P. , Mol M. O. , Yao J. J. , Fan L. , Yang D. , Liu K. , Li G. 
Published: September 2017

ObjectivesThe length of the tourniquet time during total knee arthroplasty (TKA) is related to the incidence of post-operative deep vein thrombosis (DVT). Our aim in this study was to investigate the effect of the early release of the tourniquet on the incidence of DVT in patients undergoing TKA.MethodsA total of 200 patients who underwent TKA between November 2015 and November 2016 were prospectively enrolled. The tourniquet was inflated before surgery and released immediately after the introduction of the components (early release group). This group was compared with a retrospective cohort of 200 primary TKAs, in which the tourniquet was released after the dressings had been applied (late release group). The presence of a DVT was detected using bilateral lower limb ultrasonography. Peri-operative clinical and follow-up data were collected for analysis.ResultsThe incidence of DVT in the early release group (9 of 196, 4.6%) was significantly lower compared with the late release group (24 of 200, 12%; odds ratio (OR) 0.35, 95% confidence interval (CI) 0.16 to 0.78, p = 0.008). The incidence of proximal DVT in the early release group (1 of 196 (0.5%)) was significantly lower than in the late release group (8 of 196, 4%; OR 0.12, 95% CI 0.02 to 0.99, p = 0.020). Although the mean intra-operative blood loss was higher in the early release group, the mean post-operative drainage, total blood loss, transfusion requirements and complications were not significantly different in the two groups.ConclusionIn patients who undergo TKA, releasing the tourniquet early is associated with a decreased incidence of DVT, without increasing the rate of complications. Cite this article: Bone Joint Res 2017;6:535–541.
Are the Intentions to Entrepreneurship of Men and Women Shaped Differently? The Impact of Entrepreneurial Role-Model Exposure and Entrepreneurship Education
Authors: Entrialgo M. , Iglesias V. 
Published: September 2017

AbstractHow the exposure to role models and entrepreneurship education shape perceptions and attitudes toward entrepreneurship differently in men and women is analyzed in the context of Ajzen’s theory of planned behavior. To this end, structural equation modeling is applied to data from a sample of 338 final-year undergraduates. The results show that external factors seem to be more critical in the case of women to generate entrepreneurial behavior. In particular, exposure to parental role models has a significantly more favorable influence on attitude toward entrepreneurship in women than men, and exposure to entrepreneurship education has a greater effect over their perceived entrepreneurial behavior control in women than in men.
Analysis of Dune Erosion on the Coast of South Baltic Sea Taking into Account Dune Landslide Processes
Authors: Szmytkiewicz Piotr , Zabuski Lesław 
Published: September 2017

Abstract
An analysis was carried out to determine the influence of landslide process at a few meters depth under the dune surface on the rebuilding of the dune. In the first step, calculations were done using the XBEACH model to determine seabed rebuilding as well as shore and dune undercutting for the assumed hydrologic and hydrodynamic conditions. Next, the obtained tachymetric profile of the dune and beach was fed into the FLAC2D program, and calculations of stress distribution, displacements and stability conditions were made. In this way, landslide movement was identified. The theoretical investigations clearly prove that waves attacking the dune not only cause surface erosion, but also trigger a landslide within the dune mass to a maximum depth of about 5 m. It results in a lowering of the dune crown by about 0:6 ÷ 0:7 m. Numerical models such as XBEACH, SBEACH or CSHORE do not take into account landslide occurrence, and thus underestimate dune erosion.
Moisture transport and sorption in beech and spruce barks
Authors: Rémond Romain , Barros Livia Cipriano Almeida , Almeida Giana 
Published: September 2017

Abstract
The bark-water relation and the moisture transport in bark are essential for the living tree but also for the industrial utilization of bark. Thus the bark-water relation of beech (Fagus sylvatica) and spruce (Picea abies) have been studied in the present work. The sorption isotherms were determined at 35°C for both wood and bark and the water diffusivity was measured under steady state conditions (cup method) and under unsteady state conditions, i.e. via sorption test. The sorption isotherms were calculated based on the Hailwood-Horrobin (HH) model. It was observed that beech wood and bark have a similar hygroscopic behavior, whereas spruce bark is more hygroscopic than spruce wood in all the relative humidity (RH) ranges. The radial diffusivity was in the range 1.2·10−11–2.2·10−11 m2 s−1 for spruce and beech bark, respectively, when the driving force of the diffusion is the gradient of bound water.
Functional interaction between N-methyl-D-aspartate receptor and ascorbic acid during neuropathic pain induced by chronic constriction injury of the sciatic nerve
Authors: Saffarpour Sepideh , Nasirinezhad Farinaz 
Published: September 2017

Abstract

Background:
Neuropathic pain is a chronic pain condition, which is resistant to therapy. Ascorbate was released because of the activation of glutaminergic neurons. Due to the important role of N-methyl-D-aspartate (NMDA) receptors in the pathophysiology of neuropathic pain, this study investigated the analgesic efficacy of ascorbic acid (AA) in neuropathic pain condition and the role of NMDA receptors in this effect.

Methods:
For this purpose, adult male rats were randomly allocated to experimental groups (n=8 in each group). Neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve. During the second week after CCI, animals received a single injection of 1, 3, 5, or 10 mg/kg of AA intraperitoneally and pain threshold was determined 15 and 60 min later. The antinociceptive effect of chronic administration was also evaluated by intraperitoneal injection (IP) of 3 mg/kg AA for 3 weeks. To determine the role of NMDA receptors, separate groups of animals 30 min after single injection of AA (1 mg/kg) animals received i.p. injection of ketamine (5 mg/kg), MK-801 (0.01 mg/kg), or glutamate (1000 nmol) and were tested 20 min afterwards. Data analyzed by ANOVA and Newman-Keuls tests and p<0.05 were considered as significant.

Results:
IP of 3, 5 and 10 mg/kg increased the pain threshold during the second week after CCI (p<0.05, F=3 in tactile allodynia and p<0.01, F=3.2 in thermal and mechanical hyperalgeisa). Chronic administration of AA also produced antinociceptive effect. Ascorbic acid (1 mg/kg, i.p.) inhibited MK-801 and ketamine-induced antinociception response significantly (p<0.001, F=2). It also prevented the analgesic effect of glutamate administration (p<0.001, F=2).

Conclusions:
The results indicated that AA produced a dose-dependent antinociceptive effect that seems to mediate through its interaction with NMDA receptors.
Control model design to limit DC-link voltage during grid fault in a dfig variable speed wind turbine
Authors: Nwosu Cajethan M. , Ogbuka Cosmas U. , Oti Stephen E. 
Published: September 2017

Abstract
This paper presents a control model design capable of inhibiting the phenomenal rise in the DC-link voltage during grid- fault condition in a variable speed wind turbine. Against the use of power circuit protection strategies with inherent limitations in fault ride-through capability, a control circuit algorithm capable of limiting the DC-link voltage rise which in turn bears dynamics that has direct influence on the characteristics of the rotor voltage especially during grid faults is here proposed. The model results so obtained compare favorably with the simulation results as obtained in a MATLAB/SIMULINK environment. The generated model may therefore be used to predict near accurately the nature of DC-link voltage variations during fault given some factors which include speed and speed mode of operation, the value of damping resistor relative to half the product of inner loop current control bandwidth and the filter inductance.
The BNS-invariant for Artin groups of circuit rank 2
Authors: Almeida Kisnney 
Published: September 2017

Abstract
The BNS-invariant or

Σ
1

{\Sigma^{1}}

-invariant is the first of a series of geometric invariants of finitely generated groups defined in the eighties that are deeply related to finiteness properties of their subgroups, although they are very hard to compute. Meier, Meinert and VanWyk have obtained a partial description of

Σ
1

{\Sigma^{1}}

of Artin groups, but the complete description of the general case is still an open problem. Let the circuit rank of an Artin group be the free rank of the fundamental group of its underlying graph. Meier, in a previous work, obtained a complete description for Artin groups of circuit rank 0, i.e., whose underlying graphs are trees. In a previous work we have proved, in joint work with Kochloukova, the same description to be true for Artin groups of circuit rank 1. In this paper we prove the description to be true for every Artin group of circuit rank 2.
Simultaneous determination of the magnetic field and the electric potential in the Schrödinger equation by a finite number of boundary observations
Authors: Ben Aïcha Ibtissem , Mejri Youssef 
Published: September 2017

Abstract
We study the inverse problem of determining the magnetic field and the electric potential appearing in the magnetic Schrödinger equation from the knowledge of a finite number of lateral observations of the solution. We prove a Lipschitz stability estimate for both coefficients simultaneously by choosing the “initial” conditions suitably.
Pediatric differentiated thyroid carcinoma: trends in practice and outcomes over 40 years at a single tertiary care institution
Authors: Olmsted Courtney , Arunachalam Rajalakshmi , Gao Xiang , Pesce Liuska , Lal Geeta 
Published: September 2017

AbstractBackground:This study aims to analyze changes in characteristics, practice and outcomes of pediatric differentiated thyroid cancer (DTC) at our tertiary care institution.Methods:Patients <21 years of age diagnosed between 1973 and 2013 were identified. Clinicopathological data, treatment and outcomes were obtained by a retrospective review.Results:Thirteen males and 68 females were divided into Group A (n=35, diagnosed before July 1993) and Group B (n=46, diagnosed after July 1993). Group B was more likely to undergo neck ultrasound (US) (70% vs. 23%, p<0.0001) and fine-needle aspiration (FNA) biopsy (80% vs. 26%, p<0.0001). Patients in Group B more often underwent total thyroidectomy as a definitive surgical treatment (87% vs. 69%, p=0.04). There was no difference in radioactive iodine use. Recurrence-free survival was similar.Conclusions:Increased use of US and FNA has affected initial surgical management in the latter part of the study, possibly due to extension of adult DTC guidelines. The effects of the new pediatric DTC guidelines need further study.
Pseudohypoparathyroidism type 1B associated with assisted reproductive technology
Authors: Fernandez Monica , Zambrano Maria Jose , Riquelme Joel , Castiglioni Claudia , Kottler Marie-Laure , Jüppner Harald , Mericq Veronica 
Published: September 2017

AbstractEvidence suggests an increased incidence of imprinting disorders in children conceived by assisted reproductive technologies (ART). Maternal loss-of-methylation atEstablished factsNovel Insights