bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response to: Reflections on ‘Have we lost sleep?’
Authors: Boyce Niall Patrick 
Published: September 2024

AbstractI would like to thank Professor Ekirch for his reflections on ‘Have we lost sleep?’, which contain several points that I have already responded to within the paper following his peer review of my original submission to Medical History in 2023 (Professor Ekirch having voluntarily identified himself as a reviewer in a normally double-blind process). I acknowledge that the focus of my paper was on Ekirch’s original work from 2001; if I did not engage as he would have wished with his subsequent publications, this was simply because I do not perceive the same substantial developments in his thinking and research on the subject that he does. Indeed, the present critique by Ekirch amounts essentially to more of the same: a long list of references and quotes but little detailed discussion of any individual source. As my paper demonstrates, seemingly unambiguous evidence from a brief quotation can become less clear-cut when placed in context. I am sorry if I deploy the word ‘might’ more than Ekirch would like. This reflects, I hope, a healthy degree of uncertainty and intellectual humility in my approach to the complex issue of pre-industrial sleep. To extend Ekirch’s metaphor, if the jigsaw puzzle that both he and I are trying to assemble can take the form of a cat or a dog, it is possible that its true form is neither animal. The extent to which people woke in the night in pre-industrial Europe, the duration of such awakening, and the predominant cultural attitude towards this—concern, acceptance, or indifference—are topics about which it would seem wise to avoid sweeping statements and generalisations, given the relatively long period covered and the social, cultural, and individual diversity that must be taken into consideration. I can only repeat that I think amassing more brief references, and selectively citing relatively small physiological studies and anthropological evidence from global settings, is unlikely to provide much clarity, let alone definitive answers. I welcome Professor Ekirch’s contribution to this discussion as an indication that the question of segmented sleep in early modern Europe is by no means settled but is a matter of ongoing debate.
Setting the tone: the diffusion of moral and moral-emotional appeals across political and public discourse
Authors: Widmann Tobias , Simonsen Kristina Bakkær 
Published: September 2024

Abstract
Whether a topic is seen in a moral or moral-emotional light has significant political implications. Yet, we lack knowledge about the process of moralization: Who defines the way topics are communicated about? Where prior research has investigated the relative power of different actors to place a topic on the agenda or shape opinions, we study who sets the moral and moral-emotional tone of debate. To do so, we zoom in on immigration discourse in Germany and analyze fine-grained social media data from politicians, political parties, newspapers, and members of the public over a period of more than four years. After employing a transformer model to identify moral and moral-emotional appeals, we use structural vector autoregression models to demonstrate the important role of radical-right challengers in shaping public discourse in a negative moral-emotional direction. The results inform theories of moralization and political entrepreneurship.
Guaranteed real-time cooperative collision avoidance for n-DOF manipulators
Authors: Rodríguez-Seda Erick J. , Kutzer Michael D. M. 
Published: September 2024

AbstractThis paper presents a decentralized, cooperative, real-time avoidance control strategy for robotic manipulators. The proposed avoidance control law builds on the concepts of artificial potential field functions and provides tighter bounds on the minimum safe distance when compared to traditional potential-based controllers. Moreover, the proposed avoidance control law is given in analytical, continuous closed form, avoiding the use of optimization techniques and discrete algorithms, and is rigorously proven to guarantee collision avoidance at all times. Examples of planar and 3D manipulators with cylindrical links under the proposed avoidance control are given and compared with the traditional approach of modeling links and obstacles with multiple spheres. The results show that the proposed avoidance control law can achieve, in general, faster convergence, smaller tracking errors, and lower control torques than the traditional approach. Furthermore, we provide extensions of the avoidance control to robotic manipulators with bounded control torques.
The Love Of God And The Liturgy
Authors: Evans Illtud 
Published: September 2024

God is Love: that is his name, that is his life, and God known must be
God loved, God worshipped. ‘O taste and see how good the Lord is.’ The mind
awakens to goodness and the will moves to possess it. God first loved us:
that is what his goodness means. And our answer is to love him in return.
For love is to be expressed. it is not a notion to be cherished, a choice in
reserve; rather is it a life and all of a life, imperative and
lasting.
Man is made for God: made to worship him, therefore, to give him the
praise and acknowledgment his goodness demands. That is what religion is
for: giving God what is his due, not adequately indeed, as though man on his
own might ever match the infinite love of Love himself.
The Love Of God In Our Lives
Authors: Farrell Ambrose 
Published: September 2024

Supernatural charity, ‘is the love which refers all things to God above
all things, even man himself. Caritas or Agape is
essentially a grace. From the New Testament we learn that God's ‘design was
and is to animate man with his own love that man, in and through God's love
or grace, should have a kind of equality of friendship, such that he could
know God as God knows himself, and love God as God loves himself in the
Blessed Trinity'.1
St Paul's preaching of love was to the Jews a stumbling block and to the
Gentiles mere folly. This is a love which abandons all thought of self, and
becomes lost in its object. Its very opposite is that type of self-interest
which makes people use others for their own ends, or to gloat over their
misfortunes.
Logos
Authors: Elwes Columba Gary 
Published: September 2024

It is not unreasonable to try to discover why St John chose the Greek
word ‘logos’ in describing the second person of the blessed Trinity to
Greek-speaking converts. The only way to discover why is to see just what
meaning it had in current speech to induce him to consider it suitable for
his purpose; and to see secondly what modification or modifications he had
to introduce into its meaning so that it really would fulfil its function as
a key word in Trinitarian doctrine. We may find that its chief virtue was
that it was, of all the terms to hand, least likely to be
misunderstood.
The word ‘logos’ was used by Plato, the Stoics, Philo and Plutarch. It
was current coinage in Greek thought, one of those words whose meaning was
fluid enough, somewhat as democracy or liberty are in our politically-minded
age. But at the back of all these interpretations or uses and shades of
meaning of ‘logos', there still remained one which may be summed up in
another: reason.
Methylome-wide association study of multidimensional resilience
Authors: Vazquez Alexandra Y. , Burt S. Alexandra , Mitchell Colter , Klump Kelly L. , Hyde Luke W. , Clark Shaunna L. 
Published: September 2024

Abstract
Although resilient youth provide an important model of successful adaptation to adversity, we know relatively little about the origins of their positive outcomes, particularly the role of biological mechanisms. The current study employed a series of methylome-wide association studies to identify methylomic biomarkers of resilience in a unique sample of 276 twins within 141 families residing in disadvantaged neighborhoods. Results revealed methylome-wide significant differentially methylated probes (DMPs) for social and academic resilience and suggestive DMPs for psychological resilience and resilience across domains. Pathway analyses informed our understanding of the biological underpinnings of significant differentially methylated probes. Monozygotic twin difference analyses were then employed to narrow in on DMPs that were specifically environmental in origin. Our findings suggest that alterations in the DNA methylome may be implicated in youth resilience to neighborhood adversity and that some of the suggestive DMPs may be environmentally engendered. Importantly, our ability to replicate our findings in a well-powered sample was hindered by the scarcity of twin samples with youth exposed to moderate to substantial levels of adversity. Thus, although preliminary, the present study is the first to identify DNA methylation biomarkers of academic and social resilience.
How Satisfaction Lead to Volunteer Role Identity? Revisiting Identity Salience applied to Volunteer Research
Authors: Benito-Ballesteros Álvaro , Chacón Fernando , Osa-Subtil Iria 
Published: September 2024

Abstract
Many studies have considered satisfaction as a necessary precursor for developing volunteer role identity (VRI). However, the mechanism involved in that relationship and whether diverse types of satisfaction from volunteering literature are part of this relationship remain unclear. We propose that satisfaction may promote the development of VRI by augmenting the identity saliency of the volunteer role. To address identity salience, we adopt a dual-concept approach, measuring the identity importance and identity invocation of the volunteer role. To investigate the hypothesis, we performed multiple general lineal mediation models employing identity importance and identity invocation as simultaneous mediators of the satisfaction-VRI relationship. A sample of 227 volunteers from different organizations completed an online questionnaire remotely. The results indicate that task satisfaction and motivational satisfaction, but not organizational satisfaction, significantly predict volunteer role identity—both directly and indirectly through the mediating roles of identity importance and identity invocation. Future work may continue investigating the paths through which satisfaction and other factors may promote volunteer role identity.
One‐Step Local Acceleration Process of Ultra‐Relativistic Electrons in the Center of the Outer Radiation Belt: Observations
Authors: Guo Deyu , Wang Dedong , Shprits Yuri , Xiang Zheng , Ni Binbin , Saikin Anthony , Drozdov Alexander Y. , Szabo‐Roberts Matyas , Wang Jianhang , Liu Yangxizi , Dong Junhu 
Published: September 2024

AbstractUltra‐relativistic (>3 MeV) electrons are considered as a novel, separate population in the Earth's radiation belts since their loss and acceleration features are distinct from relativistic (∼MeV) electrons. The dominant acceleration mechanism of ultra‐relativistic electrons remains a subject of ongoing debate. Some studies suggest that the acceleration mechanism of ultra‐relativistic electrons is energy‐dependent: local acceleration dominants the enhancement of ∼3–5 MeV electrons while two‐step acceleration process leading by radial diffusion effects for ∼7 MeV electrons. However, a recent study (https://doi.org/10.1126/sciadv.abc0380) theoretically demonstrated that local acceleration could accelerate electrons up to >7 MeV directly under the extreme plasma depletion. In this study, we report four enhancement events of ultra‐relativistic electrons that occurred in September and October 2017. Analysis of phase space density (PSD) radial profiles and contours demonstrate that local acceleration plays the dominant role in the enhancements of ∼7 MeV electrons in mid‐September and mid‐October, supported by persistently growing peaks in electron PSD. While enhancements of ultra‐relativistic electrons in other two events still show energy‐dependent phenomenon, our results provide the observation evidence that one‐step local acceleration process can lead to the enhancement of ∼7 MeV electrons in some events. We suggest that the acceleration process of ultra‐relativistic electrons may be subject to the efficiency of local acceleration.
The Sierra Madre Oriental Orocline: Paleomagnetism of the Nazas Province in NE Mexico
Authors: Guerra Roel Rafael , Pastor Galán Daniel , Chávez‐Cabello Gabriel , Ramírez‐Peña César Francisco , Aranda Gómez José Jorge , Patiño Méndez Gerardo , Giovanny Nova R. , Rodríguez‐Parra Alejandro , Molina Garza Roberto Stanley 
Published: September 2024

AbstractCurved mountain belts are spectacular natural features that contain crucial 3D information about the tectonic evolution of orogenic systems in the absence of other kinematic markers. The Mesozoic units exposed in the Mexican Fold and Thrust Belt in northeastern Mexico show a striking curvature, whose kinematic history has not been studied. The existing tectonic models of the region simply assumed the shape of the tectonic units as an inherent feature to the orogen. We investigated the kinematic history of this curvature through paleomagnetism and rock magnetism analyses, coupled with an exhaustive review of available published literature. The studied data sets indicate a protracted history of (re)magnetizations that occurred during the Late Jurassic‐Paleocene times at least during the Late Jurassic, Cretaceous and early Eocene. More significantly, they show significant counterclockwise rotations in the northern flank of the curvature and moderate clockwise vertical axis rotations along its southern flank. This data set suggests that the Sierra Madre Oriental was a linear belt that experienced oroclinal bending or buckling during the Cretaceous to early Eocene period (120–50 Ma).
Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials
Authors: Khouja Mouhamad , Jiang Linmiao , Pal Karol , Stewart Peter James , Regmi Binaya , Schwarz Martin , Klapper Wolfram , Alig Stefan K. , Darzentas Nikos , Kluin-Nelemans Hanneke C. , Hermine Olivier , Dreyling Martin , Gonzalez de Castro David , Hoster Eva , Pott Christiane ,   On behalf of the European Mantle Cell Lymphoma Network
Published: September 2024

AbstractRecent studies highlighted genetic aberrations associated with prognosis in Mantle Cell lymphoma (MCL), yet comprehensive testing is not implemented in clinical routine. We conducted a comprehensive genomic characterization of 180 patients from the European MCL network trials by targeted sequencing of peripheral blood DNA using the EuroClonality(EC)-NDC assay. The IGH::CCND1 fusion was identified in 94% of patients, clonal IGH-V-(D)-J rearrangements in all, and 79% had ≥1 somatic gene mutation. The top mutated genes were ATM, TP53, KMT2D, SAMHD1, BIRC3 and NFKBIE. Copy number variations (CNVs) were detected in 83% of patients with RB1, ATM, CDKN2A/B and TP53 being the most frequently deleted and KLF2, CXCR4, CCND1, MAP2K1 and MYC the top amplified genes. CNVs and mutations were more frequently observed in older patients with adverse impact on prognosis. TP53mut, NOTCH1mut, FAT1mutTRAF2del, CDKN2A/Bdel and MAP2K1amp were linked to inferior failure-free (FFS) and overall survival (OS), while TRAF2mut, EGR2del and BCL2amp related to inferior OS only. Genetic complexity (≥3 CNVs) observed in 51% of analysed patients was significantly associated with impaired FFS and OS. We demonstrate that targeted sequencing from peripheral blood and bone marrow reliably detects diagnostically and prognostically important genetic factors in MCL patients, facilitating genetic characterization in clinical routine.
Sintilimab combined with anlotinib and chemotherapy as second-line or later therapy in extensive-stage small cell lung cancer: a phase II clinical trial
Authors: Han Xiao , Guo Jun , Li Lingyu , Huang Yong , Meng Xue , Wang Linlin , Zhu Hui , Meng Xiangjiao , Shao Qian , Li Xing , Zhang Yan , Wang Jin , Chen Yanhua , Zhang Yingjie , Chen Yiru , Zhu Changbin , Wang Zhehai 
Published: September 2024

AbstractTreatment options for patients with relapsed extensive-stage small cell lung cancer (ES-SCLC) remain scarce. This study aims to evaluate the efficacy and safety of combining anlotinib and sintilimab plus chemotherapy as a second line or later therapy for ES-SCLC patients. This is a phase II clinical trial (ChiCTR2100049390) conducting at Shandong Cancer Hospital. Patients with ES-SCLC and received at least one prior systemic treatment were enrolled. The trial design involved a combination therapy (sintilimab, anlotinib, and nab-paclitaxel) administered over six 21-day cycles, followed by maintenance sintilimab therapy. The primary endpoint was objective response rate (ORR). Circulating tumor DNA sequencing was employed for exploratory analysis. From July 2021 to April 2023, 25 eligible patients were enrolled. The confirmed ORR was 60% (95% CI: 38.7–78.9%) and the DCR was 76% (95% CI: 54.9–90.6%). The mPFS was 6.0 months (95% CI: 5.4–9.7), and the 6-month PFS rate was 49.2%. The mOS was 13.4 months (95% CI: 11.8-NR), with a 12-month survival rate of 62.2%. Treatment-related adverse events (TRAEs) of any grade occurred in 80% of patients, with the most common being fatigue (40%) and nausea (32%). TRAEs of Grade 3 or higher were reported in 12% of patients. ctDNA analysis indicated that low on-treatment blood tumor mutation burden was associated with longer PFS and OS and a potential role of KMT2D mutation in treatment resistance. This combination therapy shows promising efficacy and a manageable safety profile as a second-line or later treatment for ES-SCLC, with genomic insights providing potential biomarkers for treatment response.
Neurotransmitter recognition by human vesicular monoamine transporter 2
Authors: Im Dohyun , Jormakka Mika , Juge Narinobu , Kishikawa Jun-ichi , Kato Takayuki , Sugita Yukihiko , Noda Takeshi , Uemura Tomoko , Shiimura Yuki , Miyaji Takaaki , Asada Hidetsugu , Iwata So 
Published: September 2024

AbstractHuman vesicular monoamine transporter 2 (VMAT2), a member of the SLC18 family, plays a crucial role in regulating neurotransmitters in the brain by facilitating their uptake and storage within vesicles, preparing them for exocytotic release. Because of its central role in neurotransmitter signalling and neuroprotection, VMAT2 is a target for neurodegenerative diseases and movement disorders, with its inhibitor being used as therapeutics. Despite the importance of VMAT2 in pharmacophysiology, the molecular basis of VMAT2-mediated neurotransmitter transport and its inhibition remains unclear. Here we show the cryo-electron microscopy structure of VMAT2 in the substrate-free state, in complex with the neurotransmitter dopamine, and in complex with the inhibitor tetrabenazine. In addition to these structural determinations, monoamine uptake assays, mutational studies, and pKa value predictions were performed to characterize the dynamic changes in VMAT2 structure. These results provide a structural basis for understanding VMAT2-mediated vesicular transport of neurotransmitters and a platform for modulation of current inhibitor design.
Neuromorphic intermediate representation: A unified instruction set for interoperable brain-inspired computing
Authors: Pedersen Jens E. , Abreu Steven , Jobst Matthias , Lenz Gregor , Fra Vittorio , Bauer Felix Christian , Muir Dylan Richard , Zhou Peng , Vogginger Bernhard , Heckel Kade , Urgese Gianvito , Shankar Sadasivan , Stewart Terrence C. , Sheik Sadique , Eshraghian Jason K. 
Published: September 2024

AbstractSpiking neural networks and neuromorphic hardware platforms that simulate neuronal dynamics are getting wide attention and are being applied to many relevant problems using Machine Learning. Despite a well-established mathematical foundation for neural dynamics, there exists numerous software and hardware solutions and stacks whose variability makes it difficult to reproduce findings. Here, we establish a common reference frame for computations in digital neuromorphic systems, titled Neuromorphic Intermediate Representation (NIR). NIR defines a set of computational and composable model primitives as hybrid systems combining continuous-time dynamics and discrete events. By abstracting away assumptions around discretization and hardware constraints, NIR faithfully captures the computational model, while bridging differences between the evaluated implementation and the underlying mathematical formalism. NIR supports an unprecedented number of neuromorphic systems, which we demonstrate by reproducing three spiking neural network models of different complexity across 7 neuromorphic simulators and 4 digital hardware platforms. NIR decouples the development of neuromorphic hardware and software, enabling interoperability between platforms and improving accessibility to multiple neuromorphic technologies. We believe that NIR is a key next step in brain-inspired hardware-software co-evolution, enabling research towards the implementation of energy efficient computational principles of nervous systems. NIR is available atneuroir.org
Molecular architecture of the assembly of Bacillus spore coat protein GerQ revealed by cryo-EM
Authors: Cheng Yijia , Kreutzberger Mark A. B. , Han Jianting , Egelman Edward H. , Cao Qin 
Published: September 2024

AbstractProtein filaments are ubiquitous in nature and have diverse biological functions. Cryo-electron microscopy (cryo-EM) enables the determination of atomic structures, even from native samples, and is capable of identifying previously unknown filament species through high-resolution cryo-EM maps. In this study, we determine the structure of an unreported filament species from a cryo-EM dataset collected from Bacillus amyloiquefaciens biofilms. These filaments are composed of GerQ, a spore coat protein known to be involved in Bacillus spore germination. GerQ assembles into a structurally stable architecture consisting of rings containing nine subunits, which stacks to form filaments. Molecular dockings and model predictions suggest that this nine-subunit structure is suitable for binding CwlJ, a protein recruited by GerQ and essential for Ca2+-DPA induced spore germination. While the assembly state of GerQ within the spores and the direct interaction between GerQ and CwlJ have yet to be validated through further experiments, our findings provide valuable insights into the self-assembly of GerQ and enhance our understanding of its role in spore germination.