bluuebunny/crossref_metadata_2025_split huggingface dataset:
“TEMPO, PARA QUE TE QUERO?”: O CONCEITO DE TEMPO NAS PESQUISAS EM EDUCAÇÃO
Authors: Andrade Ana Camila de , Moraes João Carlos Pereira de , Pereira Ana Lúcia 
Published: October 2024

Este artigo visa analisar os usos e debates do conceito de tempo nas pesquisas em Educação. Como procedimento metodológico foi realizada uma revisão sistemática da literatura nas bases de dados da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior e na Biblioteca Digital de Teses e Dissertações. Dentro das bases, foram filtrados os trabalhos a partir dos descritores: “conceito de tempo” AND “educação”. Tal levantamento foi realizado em novembro de 2020, considerando o período 1998-2020. Com base em material elaborado, emergiram dezenove (19) dissertações de Mestrado e cinco (5) teses de Doutorado com a temática tempo que foram organizadas e analisadas a partir da metodologia de Análise de Conteúdo. Como resultado, elencamos quatro categorias: (1) Tempo e o trabalho pedagógico na Infância; (2) Tempo e Aspectos teóricos, históricos e filosóficos; (3) Tempo e o trabalho pedagógico com Jovens e Adultos; e (4) Tempo e Formação de Professores: pesquisa e produção do conceito. Nossos resultados apontam ainda que existem possibilidades de ampliação e a produção de novas incursões sobre a temática tempo como espaço de trabalho nas pesquisas em educação, pois ainda existem lacunas e potencialidades do conceito que podem ser explorados em estudos futuros.
Half of the Diversity Undescribed: Integrative Taxonomy Reveals 32 New Species and a High Cryptic Diversity in the Scopariinae and Crambinae of the Philippines (Lepidoptera: Crambidae)
Authors: Léger Théo 
Published: October 2024

The Crambinae and Scopariinae (Lepidoptera: Crambidae) of the Philippines are revised here using DNA barcoding and morphology. In the Scopariinae, 20 species are reported from the Philippines, of which 14 are described as new: Scoparia abo sp. n., S. aenea sp. n., S. bicornuta sp. n., S. fulvida sp. n., S. ifugaoensis sp. n., S. luzonensis sp. n., S. masiita sp. n., S. negrosensis sp. n., S. tenuispina sp. n., Eudonia penicula sp. n., Micraglossa kianganensis sp. n., and Micraglossa polisensis sp. n. In the Crambinae, 42 species are found in the Philippines, with half of them described here as new: Calamotropha anacantha sp. n., Calamotropha philippinensis sp. n., Catoptria philippinensis sp. n., Culladia pseudoscoparia sp. n., Gargela aculea sp. n., Gargela acutibrachium sp. n., Gargela bidentella sp. n. , Glaucocharis altissima sp. n., Glaucocharis hamulus sp. n., Glaucocharis kayumanggi sp. n., Glaucocharis kabundukanis sp. n., Glaucocharis negrosensis sp. n., Glaucocharis uncusellus sp. n., Glaucocharis sungay sp. n., Metaeuchromius makintabus sp. n., Metaeuchromius rizali sp. n., Microchilo bundoki sp. n., Microchilo cebuano sp. n., Microchilo imminutela sp. n., and Microchilo spinosus sp. n. Scoparia philippinensis (Hampson, 1917) and Metaeuchromius micralis (Hampson, 1919) comb. nov. as well as female genitalia of Calamotropha obliterans (Walker, 1863) are redescribed, and first descriptions of male genitalia of Glaucocharis clytia (Błeszyński, 1966) and Calamotropha unicolorellus (Zeller, 1863) are provided. Euchromius brunnealis (Hampson, 1919) syn.nov. is synonymized with Metaeuchromius micralis comb. nov. Culladia tonkinella (Walker, 1865), Eudonia barbipennis (Hampson, 1897), Gargela minuta Song, Chen & Wu, 2009, Gargela polyacantha Li, 2019, Gargela xanthocasis (Meyrick, 1897), Glaucocharis lathonia (Błeszyński, 1966) and Glaucocharis clytia (Bleszynski, 1966) are reported here for the first time from the Philippines. DNA barcodes of 359 specimens indicate a perfect match with the Molecular Operational Taxonomy Unit (“MOTU”) in 45 of the 66 morphospecies (68%), while nineteen of the morphospecies included one or more MOTUs, and three MOTUs were shared among more than one morphospecies. Forty MOTUs represented by females only suggest further unrecognized species in these groups. An apparent endemism rate of 95% is observed in mountain-dwelling Scopariinae, while the Crambinae show a lower endemism rate of roughly 50% presumably due to the occurrence of many lowland species. Further expeditions to undersampled islands and mountains will surely reveal additional species.
ESCRITA CRIATIVA NA ESCOLA:
Authors: Lopes dos Reis Taiane , dos Santos Bastos Ana Gabriela , Oliveira Lígia Vanessa Penha 
Published: October 2024

Este projeto desenvolvido na Unidade Escolar Municipal José Belmiro de Paiva junto aos alunos do 3º e 4º ano do Ensino Fundamental , buscou incentivar a escrita criativa e a leitura de textos literários enquanto atos prazerosos ainda na educação básica. Visto que, o ensino de produção textual nas escolas, têm se mostrado muitas vezes ineficazes, o que vem contribuindo para a desmotivação dos alunos em relação a prática dessas atividades. Os encontros ocorreram semanalmente, onde foram realizadas à elaboração e aplicação das oficinas, as quais constaram, oficinas de discussão, interpretação de obras e oficinas de criação. As atividades desenvolvidas partiram das leituras de Norton (2001), Damas (2006), entre outros teóricos que refletem sobre a relevância da leitura e da escrita criativa nos anos iniciais da educação. Observou-se que as oficinas realizadas proporcionaram aos alunos motivação e uma melhor desenvoltura nas produções textuais, fato demonstrado em seus textos, que foram produzidos de forma coerente e muito criativa.
A Systematic Comparison of Students Attitudes Toward Practical Work in Chemistry Department Faculty of Education, Zawia -University of Zawia
Authors: Baroud Najah 
Published: October 2024

This comparative study aims to compare the attitude toward lab work. It includes two student groups in Chemistry Department, Faculty of Education - Zawia, University of Zawia- Libya. The study includes first four semesters (FFS) students, and last four semesters (LFS) students. Their attitudes were assessed via a Google Forms online questionnaires, where sent to each group separately. The number of responses sent to the researcher was 61 for FFS and 52 for LFS. The study was carried out in the fall and spring semesters of the academic year 2023-2024. A qualitative research approach was adopted. There was a substantial difference in the percentage of questionnaire responses between the FFS group and the LFS group. This outcome supports the positive attitude toward working in chemical laboratories and highlights the benefits, which include helping students develop as professionals and gain confidence. These changes take place over the lab courses, reaching their highest point during the graduation semester when a qualified teacher produced, who after that imparts information to their students
A Novel NIPBL Variant Causes Cornelia de Lange Syndrome with horseshoe kidney and renal insufficiency: case report and literature review
Authors: Yuan Han , Fei Zhao , Chunhua Zhu 
Published: October 2024

Abstract

Background: Renal involvement is rare reported in Cornelia de Lange Syndrome (CdLS). Herein, we present one male boy who is diagnosed as CdLS that have renal involvement with findings related to the novel NIPBL variant.
Case presentation: ﻿One male boy was referred to our department because of short stature. He had synophrys with arched and thick eyebrows, long eyelashes, long philtrum. He also had short digits of the thumbs and fifth digits. ﻿Renal sonography showed ﻿horseshoe kidney. The latest serum creatine was elevated to 64.8umol/L, and eGFR (estimated Glomerular Filtration Rate) was decreased to 76.62 ml/[min·(1.73 m2)] (height=136cm). Then whole-exome sequencing showed a de novo frameshift variant of NIPBL gene (NM_133433.4: exon 47，c.8325_8326delAA，p.K2775Nfs*7) in our patient. He was diagnosed as Cornelia de Lange Syndrome.
Conclusions: We described a novel frameshift NIPBL variant that causes non-classical CdLS with horseshoe kidney and renal insufficiency. Malformation of the kidney and urinary tract may also have major clinical implications for the diagnosis and genotype–phenotype correlation of NIPBL need further investigation. ﻿
Smart Buildings: Pioneering Solutions for Climate Change Mitigation
Authors: Ale Taiwo 
Published: October 2024

Abstract

The increase in the demand for buildings to cater to the rising population and urbanization has contributed to extreme climate change due to the continuous emission of greenhouse gases during the construction and operational stages of the building. Therefore, this study seeks to investigate the potential of smart buildings as a tool for combating climate change and mitigating its adverse impacts on the environment. A mixed-methods approach of case studies, interview guides, and questionnaires were used for this study. Seven smart buildings, including both commercial and residential structures from different countries, were selected using a predefined checklist for detailed examination. Semi-structured interviews and questionnaires were conducted and administered to the building industry and energy management professionals to understand how smart buildings help mitigate climate change. The study found that smart buildings contribute to climate change mitigation not only through reduced energy consumption but also by addressing waste reduction, water conservation, and biodiversity. The findings also indicate that engaging occupants in energy-saving practices and educating them about energy usage is essential for achieving sustainability. However, the complexity, security concerns, and high costs of smart building technologies hinder their acceptance and construction. Despite these challenges, smart buildings are vital for climate mitigation. Further research is needed to explore factors influencing user acceptance of smart technologies, including psychological, social, and cultural aspects.
Retroperitoneal leiomyoma: case report of a rare case of multiple retroperitoneal leiomyomas
Authors: Rabattu Agathe , Magdelyns Manon , Danon Alix , Buxant Frédéric 
Published: October 2024

Abstract

Background: Uterine leiomyomas represent the most prevalent benign solid pelvic tumors observed in women. Their primary location is within the uterus; however, they can occasionally occur in uncommon sites, although their presence in the retroperitoneum is extremely rare. Due to their rarity in the retroperitoneum, where most tumors are malignant, establishing a preoperative diagnosis is often challenging. Clinical presentation tends to be nonspecific. Radiological examinations can reveal the presence of a retroperitoneal tumor, but the imaging findings lack specificity. Therefore, the definitive diagnosis typically requires histopathological examination.
Case presentation : We report here a case of multiple retroperitoneal leiomyomas diagnosed after a laparoscopic exploration in a 30-year-old poorly symptomatic patient, who had a previous history of an open myomectomy in 2012. We review the difficulties encountered for diagnosis and different treatment options.
Conclusion
Retroperitoneal leiomyoma should be considered as a differential diagnosis of retroperitoneal masses in women with previous history of leiomyoma removal or hysterectomy.
Comparative Efficacy of 3% Diquafosol Sodium Eye Drops in Dry Eye Patients Across Age Groups: a Propensity Score-Matched Longitudinal Study
Authors: Dong Yi , Li Zecheng , Chen Luxia 
Published: October 2024

Abstract

This study aimed to evaluate the efficacy of 3% diquafosol sodium eye drops in treating dry eye disease (DED) across different age groups using a propensity score-matched longitudinal design. Participants were divided into younger (< 40 years) and older (≥ 40 years) groups. Propensity score matching (PSM) was performed at 1:1 ratio, ensuring comparable baseline characteristics. All participants received 3% diquafosol sodium eye drops, administered six times daily for 3 months. Clinical metrics, including Dry Eye Questionnaire Score (DEQS), Fluorescein Break-Up Time (FBUT), Tear Meniscus Height (TMH), Schirmer I, Lipid Layer Thickness, Logarithm of the Minimum Angle of Resolution, Intraocular Pressure, and Meibomian Gland Loss Area, were assessed at baseline (V1), 1 month (V2), and 3 months (V3). Of the 100 DED participants, 97 completed the study. Baseline characteristics did not significantly differ between groups post-PSM. Metrics between groups at V2 and V3 did not differ significantly. Longitudinal mixed-effects models demonstrated significant improvements in DEQS, FBUT, and TMH over time in both groups. Diquafosol sodium eye drops (3%) effectively improved DED symptoms across groups, suggesting that age does not significantly affect diquafosol’s efficacy, thereby supporting its use in a broad demographic of patients with DED.
Poor diagnostic performance of the melanin-binding tracer [18F]MEL050 in human melanoma indicates biological heterogeneity
Authors: Ware Robert Edward , Kee Damien , Roselt Peter , Greguric Ivan , Katsifis Andrew , Bourdier Thomas , Noonan Wayne , Murray William , Mitchell Catherine , Downes Marnie , Shackelton Mark , McArthur Grant A , Hicks Rodney John 
Published: October 2024

Abstract

Purpose
Malignant melanoma is a highly lethal malignancy typically characterized by the expression of melanin, which is an attractive diagnostic and therapeutic target in these cancers because it is expressed in few other tissues. Following preclinical evaluation of the melanin-targeting PET tracer, [18F]-6-fluoro- N-[2-(diethylamino)ethyl] pyridine-3-carboxamide (MEL050), we sought to evaluate this agent in patients with melanoma.
Method
A phase I clinical trial was performed in ten patients with metastatic melanoma. Safety, dosimetry and diagnostic performance of intravenously administered MEL050 were evaluated. Based on results from this trial, we further assessed the prevalence and prognostic significance of loss of melanin expression in two historical patient cohorts for which there was matching histological and clinical outcome data.
Results
Across the trial cohort, no adverse safety signals resulted from MEL050 administration. The whole-body effective dose was 0.0163 mSV/MBq for an adult male and 0.0206 mSV/MBq for an adult female. The human biodistribution was favorable with low uptake in organs at high risk of metastatic spread, including the brain. Of metastatic sites identified as melanoma on FDG PET/CT, only 31/65 (48%) were positive on MEL050 PET. Four FDG + MEL050 + metastases were resected from three patients and found to be melanotic by histological examination, whereas five FDG + MEL050- metastases from two patients were amelanotic. In historical cohorts, amelanosis was more common in metastatic than primary disease (45% versus 20%) and the presence of melanin within sentinel lymph node metastases was associated with worse disease-free (HR 2.3 95% CI 1.3–4.3, p = 0.002) and disease-specific survivals (HR 3.6, 95% CI 1.4–9.7,p = 0.009) in stage III disease, compared with amelanotic sentinel lymph node metastases.
Conclusion
Our results warrant caution in the use of melanin-targeted agents for diagnosis and therapy of melanoma but further assessment of their utility as prognostic or predictive imaging biomarkers is required.
Cumulative abdominal obesity exposure and risk of endometrial cancer in young women: a population-based cohort study
Authors: LEE MINKYUNG , Heo Jung , Ahn Jiyeon , Han Kyung Do , Lee Yeon Jee , Song Yong Sang , Sohn Seo-Young , Lee Jae-Hyuk 
Published: October 2024

Abstract

BACKGROUND
Abdominal obesity is currently being investigated as an indicator of adiposity and cancer risk, and its prevalence is increasing in young women. This study aimed to examine whether cumulative abdominal obesity exposure in young women was associated with the development of endometrial cancer.
METHODS
We used data from the South Korean National Health Insurance Service for women aged 20–39 years who had completed four consecutive annual health examinations between 2009 and 2015 and had no history of cancer at baseline. Participants were categorized into five groups based on the number of abdominal obesity exposures (waist circumference ≥ 85 cm). Exposure numbers ranged from 0 to 4, indicating the frequency of abdominal obesity across the four health examinations over 4 years. The primary outcome was newly diagnosed endometrial cancer during a follow-up period of 7.12 years.
RESULTS
Among the 445,791 young women (mean [SD] age 30.82 [4.55] years), 302 (mean [SD], 32.79 [4.53] years) developed endometrial cancer. The cumulative incidence of endometrial cancer differed significantly according to the number of abdominal obesity exposures (log-rank test, P < .001). The incidence of endometrial cancer has progressively increased with abdominal obesity exposure. The multivariable-adjusted HRs for incident endometrial cancer were 1.480 (95% CI, 0.970–2.258), 2.361 (95% CI, 1.391–4.008), 4.114 (95% CI, 2.546–6.647), and 6.215 (95% CI, 4.250–9.088) for participants with exposure numbers of 1–4, respectively, compared with those with an exposure number of 0.
CONCLUSION
In this population-based nationwide cohort study of young women, we observed a progressive increase in the risk of endometrial cancer with cumulative abdominal obesity exposure.
Comparison of utilizing a hypertonic saline solution and mannitol to improve brain relaxation during craniotomy in patients with brain tumours: A prospective randomized controlled trial
Authors: Thongrong Cattleya , Tangphikunatam Worapoom , Kasemsiri Pornthep , Duangthongphon Pichayen , Kitkhuandee Amnat , Plailahan Narin , Kittiponghansa Apinya , Sripadung Darunee , Somjit Monsicha , Sabangban Lumyai , Jimarsa Thirada 
Published: October 2024

Abstract

Hyperosmolar therapy, specifically the use of mannitol, has been employed to improve brain relaxation, but mannitol use may affect hypovolemia and electrolyte imbalance. Given these risks, hypertonic saline was introduced as an alternative option; however, data on its efficacy and safety is unavailable. Researchers conducted a prospective, double-blind, randomized controlled trial. Sixty-six patients with supratentorial or posterior fossa brain tumours undergoing a craniotomy to remove the tumour were randomized into two groups. Group M received 20% mannitol at a dose of 3 ml/kg, and Group H received 3% hypertonic saline at the same dose. These solutions were administered before dural opening. The masked neurosurgeon immediately assessed the four-point brain relaxation score by direct visuality and tactile assessment after the dural opening. Both groups did not have significantly different brain relaxation scores (p value = 0.543). There was no significant difference in haemodynamic change, fluid replacement or serum osmolarity between the groups; however, urine output was greater in the mannitol group (p value = 0.003). Additionally, the postoperative neurological outcomes and one-month mortality rates were similar between the two groups. These findings suggest a 3% hypertonic saline can be considered an alternative to mannitol for improving brain relaxation during craniotomy, as it is equally effective with less urine output.
Abdominal Epilepsy：a case report and review of the literature
Authors: Zhang Ying , An Ying , Qi Jialong , Song Zhengji 
Published: October 2024

Abstract

Background
Abdominal epilepsy (AE) is a rare and often underrecognized form of epilepsy, characterized by paroxysmal abdominal pain accompanied by central nervous system (CNS) disturbances. The diverse clinical manifestations of AE frequently pose diagnostic challenges, leading to delays in definitive diagnosis.
Case Presentation:
We present two cases: a 28-year-old male (symptoms began at 18 years old) and a 55-year-old female (symptoms began at 8 years old), both with a decade-long history of intermittent abdominal pain and syncope. Despite multiple consultations and extensive evaluations, a definitive diagnosis was not reached until electroencephalography (EEG) identified characteristic epileptiform abnormalities.
Conclusion
These cases highlight the importance of considering AE as a potential diagnosis in patients, particularly children, with unexplained abdominal pain and altered consciousness, especially after ruling out more common causes. Additionally, we summarize the potential molecular mechanisms contributing to AE development, underscoring the need for heightened clinical awareness and further research.
Machine Learning-Based Prediction of Intellectual Disability in Children with Autism Spectrum Disorder: Using Behavioral Observation Techniques
Authors: Liu Xiaolin , Han Ting , Jiang Zhongquan , Hu Lifei , Li Wenhao , Song Chao 
Published: October 2024

Abstract

To construct and evaluate a LightGBM prediction model for intellectual disabilities in children with Autism Spectrum Disorder (ASD), a total of 384 ASD children who completed the Wechsler Intelligence Test were included in the analysis. The LightGBM model was trained using behavioral observation data and underwent hyperparameter tuning and feature selection. Among the ASD children, 32.9% had comorbid intellectual disabilities. The model achieved an AUC of 0.747, with overall quality of relationships, unusual sensory interests, and gestures/postures being the top predictive features. The results demonstrate the potential clinical application of the LightGBM model in predicting comorbid intellectual disabilities in children with ASD.
Identifying biomarkers distinguishing sepsis after trauma from trauma-induced SIRS based on metabolomics data: A retrospective study
Authors: Gou Yi , Liu Jing-jing , Zhang Jun-fei , Yang Wan-peng , Yang Jian-Zhong , Feng Ke 
Published: October 2024

Abstract

Background
Sepsis after trauma and trauma-induced SIRS may present with similar symptoms, so it is a great challenge to distinguish sepsis after trauma from trauma-induced SIRS. Besides, trauma-induced SIRS uncovers the occurrence of sepsis after trauma. Thus, there is a need for biomarkers to distinguish them. We hypothesized that sepsis after trauma leads to different changes in blood metabolism than trauma-induced SIRS and searched for metabolite biomarkers in blood to distinguish between the two conditions.
Methods
This study retrospectively analyzed the existing blood metabonomics data from the patients with severe trauma (100 cases), patients with sepsis after trauma (50 cases), and the non-trauma controls (50 cases). We screened out 40 patients with trauma-induced SIRS from the 100 severe trauma patients and then used a pairwise comparison between patients with sepsis after trauma and trauma-induced SIRS to screen the differential metabolites as biomarkers distinguishing sepsis after trauma from trauma-induced SIRS.
Results
In total, 413 metabolites could differentiate sepsis after trauma patients from the trauma-induced SIRS. Using partial least‑squares discriminant analysis, we showed that sepsis after trauma patients was metabolically distinct from the trauma-induced SIRS. The main distinguishing metabolites were LPC O-22:1, uric acid, 23-Norcholic acid, PC O-38:1, and PC O-42:3 (AUC: 0.875 to 0.910).
Conclusions
Our study has identified the potential of employing metabolic biomarkers for differentiation of sepsis after trauma from trauma-induced SIRS. In particular, LPC O-22:1, uric acid, 23-Norcholic acid, PC O-38:1, and PC O-42:3 demonstrated potential as important biomarkers for distinguishing sepsis after trauma from trauma-induced SIRS. These biomarkers provide a basis for further research on identifying biomarkers distinguishing sepsis after trauma from trauma-induced SIRS based on targeted metabolomics.