bluuebunny/crossref_metadata_2025_split huggingface dataset:
TALE-directed local modulation of H3K9 methylation shapes exon recognition
Authors: Bieberstein Nicole I. , Kozáková Eva , Huranová Martina , Thakur Prasoon K. , Krchňáková Zuzana , Krausová Michaela , Oesterreich Fernando Carrillo , Staněk David 
Published: July 2016

AbstractIn search for the function of local chromatin environment on pre-mRNA processing we established a new tool, which allows for the modification of chromatin using a targeted approach. Using Transcription Activator-Like Effector domains fused to histone modifying enzymes (TALE-HME), we show locally restricted alteration of histone methylation modulates the splicing of target exons. We provide evidence that a local increase in H3K9 di- and trimethylation promotes inclusion of the target alternative exon, while demethylation by JMJD2D leads to exon skipping. We further demonstrate that H3K9me3 is localized on internal exons genome-wide suggesting a general role in splicing. Consistently, targeting of the H3K9 demethylase to a weak constitutive exon reduced co-transcriptional splicing. Together our data show H3K9 methylation within the gene body is a factor influencing recognition of both constitutive and alternative exons.
Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity
Authors: Cunningham Peter S. , Ahern Siobhán A. , Smith Laura C. , da Silva Santos Carla S. , Wager Travis T. , Bechtold David A. 
Published: July 2016

AbstractGrowing evidence indicates that disruption of our internal timing system contributes to the incidence and severity of metabolic diseases, including obesity and type 2 diabetes. This is perhaps not surprising since components of the circadian clockwork are tightly coupled to metabolic processes across the body. In the current study, we assessed the impact of obesity on the circadian system in mice at a behavioural and molecular level and determined whether pharmacological targeting of casein kinase 1δ and ε (CK1δ/ε), key regulators of the circadian clock, can confer metabolic benefit. We demonstrate that although behavioural rhythmicity was maintained in diet-induced obesity (DIO), gene expression profiling revealed tissue-specific alteration to the phase and amplitude of the molecular clockwork. Clock function was most significantly attenuated in visceral white adipose tissue (WAT) of DIO mice and was coincident with elevated tissue inflammation and dysregulation of clock-coupled metabolic regulators PPARα/γ. Further, we show that daily administration of a CK1δ/ε inhibitor (PF-5006739) improved glucose tolerance in both DIO and genetic (ob/ob) models of obesity. These data further implicate circadian clock disruption in obesity and associated metabolic disturbance and suggest that targeting of the clock represents a therapeutic avenue for the treatment of metabolic disorders.
General existence of locally distinguishable maximally entangled states only with two-way classical communication
Authors: Tian Guojing , Wu Xia , Cao Ya , Gao Fei , Wen Qiaoyan 
Published: July 2016

AbstractIt is known that there exist two locally operational settings, local operations with one-way and two-way classical communication. And recently, some sets of maximally entangled states have been built in specific dimensional quantum systems, which can be locally distinguished only with two-way classical communication. In this paper, we show the existence of such sets is general, through constructing such sets in all the remaining quantum systems. Specifically, such sets including p or n maximally entangled states will be built in the quantum system of (np − 1) ⊗ (np − 1) with n ≥ 3 and p being a prime number, which completes the picture that such sets do exist in every possible dimensional quantum system.
All-optical modulation in Mid-Wavelength Infrared using porous Si membranes
Authors: Park Sung Jin , Zakar Ammar , Zerova Vera L. , Chekulaev Dimitri , Canham Leigh T. , Kaplan Andre 
Published: July 2016

AbstractWe demonstrate for the first time the possibility of all-optical modulation of self-standing porous Silicon (pSi) membrane in the Mid-Wavelength Infrared (MWIR) range using femtosecond pump-probe techniques. To study optical modulation, we used pulses of an 800 nm, 60 femtosecond for pump and a MWIR tunable probe in the spectral range between 3.5 and 4.4 μm. We show that pSi possesses a natural transparency window centred around 4 μm. Yet, about 55% of modulation contrast can be achieved by means of optical excitation at the pump power of 60 mW (4.8 mJ/cm2). Our analysis shows that the main mechanism of the modulation is interaction of the MWIR signal with the free charge carrier excited by the pump. The time-resolved measurements showed a sub-picosecond rise time and a recovery time of about 66 ps, which suggests a modulation speed performance of ~15 GHz. This optical modulation of pSi membrane in MWIR can be applied to a variety of applications such as thermal imaging and free space communications.
Emergence of nontrivial magnetic excitations in a spin-liquid state of kagomé volborthite
Authors: Watanabe Daiki , Sugii Kaori , Shimozawa Masaaki , Suzuki Yoshitaka , Yajima Takeshi , Ishikawa Hajime , Hiroi Zenji , Shibauchi Takasada , Matsuda Yuji , Yamashita Minoru 
Published: July 2016

Significance
The Hall effect is due to the nature of the charge carriers in a conductor, which experience the Lorentz force in the presence of magnetic field. In antiferromagnetic insulators with geometrical frustrations, charge carries are absent, but the spin degrees of freedom form disordered liquid-like states with unusual excitations that can carry heat. Here, we report the observation of the thermal version of the Hall effect in a spin-liquid state of a quantum magnet with frustrated two-dimensional kagomé structure. Our finding implies the emergence of nontrivial excitations in a spin-liquid state that experience the fictitious Lorentz force, possibly related to the geometrical phase of the quantum-mechanical wave function in many-body systems.
Quality of Life and the Complex Needs of Recovery Home Residents
Authors: Mericle Amy A. , Miles Jennifer 
Published: July 2016

Background Having a stable and safe place to live is integral to recovery from addiction. Recovery residences represent an important component in the substance use continuum of care, but research on them has been limited to certain types of recovery residences and has yet to examine quality of life among those who live in them. Methods This study presents data on the characteristics of residents ( N = 104) living in a stratified random sample of recovery homes in Philadelphia ( N = 13) as well as data from a random subsample of residents ( N = 27) who participated in 3-month follow-up interviews. Results Residents in these homes reported deficits in a variety of aspects of their lives critical to helping them initiate and sustain their recovery; many (20%) reported living in a shelter or on the streets prior to moving in, 37% had less than a high school education, and only 26% reported currently working for pay. Although the majority of residents rated their quality of life as good or very good (74%), average physical health, social relationship, and environment domain scores measured by the World Health Organization Quality of Life (WHOQOL)-Bref were generally lower than scores found among community samples. At follow-up, all residents were housed and rates of substance use (7%), criminal justice involvement (0%), and employment (44%) in the past 30 days were encouraging. Quality of life domain scores were unchanged, with the exception of psychological health, which decreased. Conclusions These findings highlight the complex needs of residents living in Philadelphia recovery homes and the role that these homes play in maintaining residents in their early recovery. Studies with larger samples of residents followed up over longer periods of time are needed to assess the role that these homes may play in promoting long-term recovery and improving the well-being of the vulnerable population of individuals who live in them.
Application of polydimethylsiloxane-based optical system for measuring optical density of microbial culture
Authors: Takahashi Yurika 
Published: July 2016

Abstract
The performance of recently developed polydimethylsiloxane (PDMS)-based optical system was tested for measuring optical density of microbial culture. The data showed that PDMS-based spectrometer is superior to “one drop” spectrometers in the accuracy, and has an advantage over conventional spectrometers in measuring dense culture without dilution.
ABA flow modelling in Ricinus communis exposed to salt stress and variable nutrition
Authors: Peuke Andreas D 
Published: July 2016

Abstract
In a series of experiments with Ricinus communis, abscisic acid (ABA) concentrations in tissues and transport saps, its de novo biosynthesis, long-distance transport, and metabolism (degradation) were affected by nutritional conditions, nitrogen (N) source, and nutrient limitation, or salt stress. In the present study these data were statistically re-evaluated, and new correlations presented that underpin the importance of this universal phytohormone. The biggest differences in ABA concentration were observed in xylem sap. N source had the strongest effect; however, nutrient limitation (particularly phosphorus limitation) and salt also had significant effects. ABA was found in greater concentration in phloem sap compared with xylem sap; however, the effect of treatment on ABA concentration in phloem was lower. In the leaves, ABA concentration was most variable compared with the other tissues. This variation was only affected by the N source. In roots, ABA was significantly decreased by nutrient limitation. Of the compartments in which ABA was quantified, xylem sap ABA concentration was most significantly correlated with leaf stomatal conductance and leaf growth. Additionally, ABA concentration in xylem was significantly correlated to that in phloem, indicating a 6-fold concentration increase from xylem to phloem. The ABA flow model showed that biosynthesis of ABA in roots affected the xylem flow of ABA. Moreover, ABA concentration in xylem affected the degradation of the phytohormone in shoots and also its export from shoots via phloem. The role of phloem transport is discussed since it stimulates ABA metabolism in roots.
Maternal birth trauma: why should it matter to urogynaecologists?
Authors: Dietz Hans P. , Wilson Peter D. , Milsom Ian 
Published: July 2016

Purpose of reviewThere is increasing awareness of the importance of intrapartum events for future pelvic floor morbidity in women. In this review, we summarize recent evidence and potential consequences for clinical practice.Recent findingsBoth epidemiological evidence and data from perinatal imaging studies have greatly improved our understanding of the link between childbirth and later morbidity. The main consequences of traumatic childbirth are pelvic organ prolapse (POP) and anal incontinence. In both instances the primary etiological pathways have been identified: levator trauma in the case of POP and anal sphincter tears in the case of anal incontinence. As most such trauma is occult, imaging is required for diagnosis.SummaryChildbirth-related major maternal trauma is much more common than generally assumed, and it is the primary etiological factor in POP and anal incontinence. Both sphincter and levator trauma can now be identified on imaging. This is crucial not only for clinical care and audit, but also for research. Postnatally diagnosed trauma can serve as intermediate outcome measure in intervention trials, opening up multiple opportunities for clinical research aimed at primary and secondary prevention.
A Proximally Based Sural Fasciocutaneous Flap for the Treatment of Recurrent Peroneal Neuropathy: A Case Report
Authors: Ohta Souichi , Ikeguchi Ryosuke , Noguchi Takashi , Kaizawa Yukitoshi , Oda Hiroki , Matsuda Shuichi 
Published: July 2016

Summary:
Surgical treatment for recurrent, common peroneal neuropathy has not been reported. Herein, we describe a successfully treated case using the proximally based sural fasciocutaneous flap after reneurolysis of the adhesive common peroneal nerve. A 33-year-old man received a neurolysis operation for entrapment neuropathy of the common peroneal nerve 2 years before first admission in our clinic. Although motor nerve conduction studies showed a marked improvement after the primary operation, the patient always required the use of a crutch because of severe pain radiating to the lower leg during standing or walking. We diagnosed adhesive neuropathy of the common peroneal nerve, and performed reneurolysis by wrapping of the released nerve with a proximally based sural fasciocutaneous flap to prevent readhesion. The radiating pain was significantly reduced at 1-month postoperation. At 1-year postoperation, the patient could walk a long distance without a crutch. Wrapping the released common peroneal nerve with a proximally based sural fasciocutaneous flap is a useful option for the treatment of recurrent, common peroneal neuropathy.
Recovery Trajectories of Executive Functioning After Pediatric TBI: A Latent Class Growth Modeling Analysis
Authors: Narad Megan E. , Treble-Barna Amery , Peugh James , Yeates Keith O. , Taylor H. Gerry , Stancin Terry , Wade Shari L. 
Published: July 2016

Objective:
To identify latent trajectories of executive functioning (EF) recovery overtime after childhood traumatic brain injury (TBI) and examine the predictive value of known risk factors within and across recovery trajectories using latent class growth modeling (LCGM).

Method:
A total of 206 children between the ages of 3 and 7 years with a moderate to severe TBI or orthopedic injury (OI) were included. LCGM was applied to identify longitudinal trajectories of postinjury EF as assessed by the Behavior Rating Inventory of Executive Functioning General Executive Composite (GEC). Separate models were estimated for the TBI and OI groups.

Results:
Two TBI trajectories—normal limits (70.8%) and clinically elevated (29.2%)—and 3 OI trajectories—normal limits (20.9%), subclinical (49.0%), and clinically elevated (30.17%)—were identified. Baseline GEC was the only predictor of class membership for all models. Both TBI trajectories demonstrated an increase in GEC over time, whereas only 1 of the 3 OI classes demonstrated this pattern. Family variables were associated with GEC across trajectories.

Conclusion:
The lack of association of injury characteristics with trajectory class membership highlights the heterogeneity in recovery after pediatric TBI. Associations of EF trajectories with family factors underscore the importance of involving the family in interventions for children with traumatic injuries.
Pilot Study to Determine the Effect of Lens and Eye Rinsing on Solution-Induced Corneal Staining (SICS)
Authors: Woods Jill , Jones Lyndon W. 
Published: July 2016

ABSTRACT

Purpose
The main purpose of this study was to determine whether two interventions (rinsing the lens before lens insertion and rinsing the ocular surface post-lens removal) had any impact on solution-induced corneal staining (SICS). In addition, the presence of hyper-reflective epithelial cells in the presence of SICS was investigated.

Methods
Twenty subjects wore new balafilcon A lenses, which had been soaked overnight in a multipurpose care product containing polyhexamethylene biguanide for 2 hours. The study was conducted across three phases. In phase 1 (investigator and subject masked, randomized eye), one lens was rinsed with nonpreserved saline before lens insertion. In phase 2 (investigator masked, randomized eye), one eye was rinsed with nonpreserved saline after lens removal, before staining assessment. Corneal staining was recorded as the percentage area of the cornea exhibiting superficial punctate staining. In both phases, ocular comfort and presence of specific symptoms were captured. In phase 3, there was no randomized treatment; confocal images of the epithelium were obtained after 2 hours of wear.

Results
In phase 1 (lens-rinse), there was no significant difference in staining between the treated and untreated eyes (84 vs. 92%, respectively; p = 0.06). In phase 2 (eye-rinse), there was also no significant difference between the treated and untreated eye (86 vs. 86%, p = 0.92). Most subjects were asymptomatic. In phase 3, images of hyper-reflective cells were captured in 97% of the eyes imaged.

Conclusions
The two rinsing procedures did not affect the level of the SICS response. Hyper-reflective epithelial cells were found to be present in a significant number of eyes exhibiting SICS, and their presence warrants further investigation.
Enviropreneurial marketing in greening corporate activities
Authors: Song-Turner Helen , Polonsky Michael 
Published: July 2016

PurposeThe purpose of this study is to explore the enviropreneurial marketing approach used by firms in China and its impact on the success of green marketing actions, with the aim of drawing useful lessons from the literature and successful green firms.Design/methodology/approachThis study follows the inductive case study approach, and the qualitative data come from a study of four firms engaging in enviropreneurial marketing activities. Interview data were triangulated with qualitative data from other sources.FindingsThe evidence from this study indicates that enviropreneurial marketing plays a central role in developing innovative product or services, adopting an innovative and pragmatic green marketing mix that differentiates and creates changes within industry and markets.Research limitations/implicationsThe main limitation of this study is that data samples are from successful firms labelled as “green” by the Chinese authorities, based on winning “official” awards. These do not necessarily represent the opinions of a cross section of firms within China with respect to enviropreneurial marketing. Future studies should include a mixed population of firms.Practical implicationsPolicy makers and marketing practitioners need to consider drivers to ensure that Chinese firms integrate enviropreneurial marketing activities, which need to complement the delivery of functional value.Social implicationsGreen initiatives/changes within the firm seem to be partly driven by the environmental orientation of these firms’ founders, thus, developing an environmental orientation in managers may be important to drive enviropreneurial marketing activities.Originality/valueThis study contributes by confirming the current literature on green marketing and examining the positive impact of enviropreneurial marketing on firms’ performance in the context of marketing in emerging markets.
Construction of garment pattern shape information system using image analysis and shape recognition techniques
Authors: Lee Jaewoong , Sul InHwan 
Published: July 2016

Purpose
– As an extended work of the previous paper (Sul, 2010), this paper provides a guideline information for an anonymous garment pattern in sewing process. The purpose of this paper is to first, provide garment pattern database. By simply taking pictures of garment patterns, the shape database is constructed. Once the shape database is prepared, data retrieval can be done by image indexing, i.e., simply inserting garment pattern boundary shape again to the database. Using shock graph methodology, the pattern sets used for database preparation can be exactly retrieved. Second, to find the nearest shape of a given input pattern shape in the database. If the input garment pattern shape does not exist in the database, the shape matching algorithm provides the next similar pattern data. The user, who is assumed to be non-expert in garment sewing process, can easily predict the position and combination information of various patterns.

Design/methodology/approach
– Image processing is used to construct the garment pattern shape database. The boundary shapes are extracted from the photographs of garment patterns and their shape recognition information, especially shock graph, is also recorded for later pattern data retrieval.

Findings
– Using the image processing technique, garment patterns can be converted to electronic format easily. Also the prepared pattern database can be used for finding the nearest shape of an additional given input garment pattern. Patterns with irregular shapes were retrieved easily, while those with a simple shape, such as rectangle, showed a little erroneous result.

Originality/value
– Shape recognition has been adopted in various industrial areas, except for garment sewing process. Using the provided methodology, garment pattern shapes can be easily saved and retrieved only by taking pictures of them.
Design and practicability evaluation: a novel platform for fabric steam ironing
Authors: Liang Shuaitong , Ding Xue Mei , Wu Xiong Ying , Wu Fan , Asmamaw Tesfaye Mulu 
Published: July 2016

Purpose
– Smooth appearance of fabrics after ironing with steam, soleplate, ironing speed and their interactions cannot be studied using household ironing machines such as hang steamer and flatiron. The purpose of this paper is to present the design and verification of a simple, low-cost test platform based on the fabric materials hang-ironing factors includes temperature, humidity, ironing speed (time).

Design/methodology/approach
– This platform achieves adjustable and stable steam flow rate, enabling any ironing speed and any temperature of soleplate below 200°C. Moreover, the whole ironing process is automatically after experiment level set ahead for better observation to the ironing process.

Findings
– Regression results of the apparatus are stable, statistical significant which is verified by the statistics under design of experiment.

Originality/value
– It is useful in other aspects such as nozzle test and improvement, new products evaluation and smooth appearance level experiment and test for new ironing product and its research. It is also useful in other aspects such as nozzle test and improvement, new products evaluation and smooth appearance level experiment and test for new ironing product and its research.