bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations of store-operated calcium entry and cyclopiazonic acid-induced endothelium-derived relaxations in aging rat thoracic aorta
Authors: Erac Y , Selli C , Tosun M 
Published: August 2017

The purpose of our study was to investigate whether endothelium-derived relaxations induced by store depletion are altered in aging rat thoracic aorta. Vascular responses were measured in aortic segments isolated from young (2–4 month) and old (20–24 month) male Sprague-Dawley rats. In phenylephrine-contracted intact tissues, receptor-mediated and receptor-independent endothelium-derived relaxations were induced by acetylcholine (ACh) and sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) blocker cyclopiazonic acid (CPA), respectively. In addition, CPA-induced changes in intracellular calcium levels were monitored in fura-2-loaded endothelium-denuded tissues. Real-time quantitative reverse transcription polymerase chain reaction and western blot analysis were performed to determine the transient receptor potential canonical (TRPC) 4 mRNA and protein levels. Endothelial TRPC4 mRNA levels were apparently decreased in aging rats. Immunoblot analysis showed that TRPC4 protein levels significantly decreased in intact aorta from 20- to 24-month-old rats compared to that from 2- to 4-month-old rats. ACh- and CPA-induced endothelium-dependent relaxations decreased in old rat aorta without any change in direct vasodilation induced by sodium nitroprusside. Store-operated Ca2+ entry (SOCE) induced by CPA was significantly decreased, whereas sarcoplasmic reticulum Ca2+ release was unaffected in endothelium-denuded aging rat aorta. In conclusion, TRPC4 downregulation could be associated with decreased endothelium-dependent vasorelaxations. As endothelial nitric oxide synthase is activated by SOCE-induced caveolar internalization, tracking the expression levels of SERCA, ion channels, and/or associated proteins involved in SOCE would lead to the development of novel therapeutics for age-related vasospastic disorders with dysfunctional endothelium.
Effect of pectin feeding on obesity development and duodenal alkaline phosphatase activity in Sprague-Dawley rats fed with high-fat/high-energy diet
Authors: Šefčíková Z , Raček L 
Published: August 2017

PurposeThe objective of this study was to evaluate whether pectin feeding would affect the small intestinal function and whether these changes would lead to obesity prevention in rats fed with high-fat diet. Three groups of weaned male rats (ad lib. fed; rats fed with diet containing 15% w/w of citrus pectin; restrictedly pair-fed rats) were fed with either a standard diet (9.5% fat) or a high-fat diet (30% fat) for 10 days.ResultsOur results revealed that pectin feeding led to significant decreases in body weight, energy intake and fat pad weight in rats fed with the standard as well as high-fat diet. Moreover, compared to the restrictedly pair-fed rats, in both groups of rats fed with the diet containing pectin, significant decrease in duodenal alkaline phosphatase (AP) activity was observed in histochemically stained cryostat sections. In contrast, despite their lower energy intake, restrictedly pair-fed rats showed similar fat pad deposition accompanied by unchanged values of AP activity in comparison to the controls.ConclusionsOur findings indicate that daily pectin consumption could be beneficial in suppressing body weight gain and reducing probability of obesity risk in rats fed with a high-fat diet.
Assessment of exhaled carbon monoxide in exacerbations of chronic obstructive pulmonary disease
Authors: Antus B , Drozdovszky O , Barta I 
Published: August 2017

IntroductionExhaled carbon monoxide (eCO) has been widely implicated as a pulmonary biomarker in respiratory diseases. The aim of this study was to investigate whether the treatment of patients with severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) could be aided by monitoring the changes in eCO.MethodsThe levels of eCO along with routine clinical parameters were analyzed in 29 current smoker and 33 ex-smoker COPD patients, first at the time of hospital admission, and again at discharge following the standard treatment. Patients with AECOPD were also stratified according to sputum bacteria.ResultsAt exacerbation, the levels of eCO were increased in current smokers compared to ex-smokers (6.0 [2.0–9.5] versus 1.0 [1.0–2.0] ppm, p < 0.001). Similarly, eCO levels were higher in smokers after treatment (7.0 [2.0–12.5] versus 1.0 [1.0–2.0] ppm, p < 0.001). Treatment of AECOPD did not affect eCO concentrations. The levels of eCO were not statistically different between bacterial and non-bacterial AECOPD either. Investigating a subgroup of current smoker patients (n = 15), there was a significant correlation between the levels of eCO and blood carboxyhemoglobin concentrations both at exacerbation and discharge. No associations were found between eCO and lung function or blood gas parameters.ConclusionOur results suggest that monitoring eCO during the treatment of AECOPD is of limited clinical value.
A study to assess frequency of peripheral arterial disease in patients presenting with acute coronary syndrome
Authors: Mukherjee Somnath , Kumar Prashant , Sinha D. P. 
Published: August 2017

Background: To determine the frequency of peripheral arterial disease (PAD) in patients presenting with acute coronary syndrome (ACS) and association of PAD with different risk factors of coronary artery disease (CAD) and to look for in hospital outcome of ACS patients with or without PAD.Methods: This cross-sectional observation study was undertaken in the department of cardiology, IPGME&R Hospital, Kolkata from June 2015 to August 2016 to recruit 199 consecutive patients admitted with ACS and were evaluated with detailed clinical history, physical examination, ABI (Ankle Brachial Index) measurement, echocardiography and appropriate blood investigations.Results: Among 199 total ACS patients, STEMI was the predominant mode of presentation (71.86%) and majorities were male. PAD was seen in 26 patients and mean age was 56.68±8.84 years. Factors independently related with PAD in acute coronary syndromes are hypertension (OR- 1.49; 95% CI: 0.615-3.232), diabetes (OR- 2.55;95% CI : 0.9762-6.6665), smoking (OR-2.55; 95% CI: 1.055-6.19), past history of CVA (OR-11.15;95% CI: 1.77-70.32), LV systolic dysfunction (OR-1.388; 95% CI:0.607-3.1742). 2 and 13 patients died within 7 days of admission among 26 ACS-PAD group (7.69%) and 173 ACS-non-PAD group (7.5%) respectively and most of them had STEMI.Conclusions: Significant numbers of ACS patients are having PAD and older age, male sex, diabetes, hypertension, smoking and LV systolic dysfunction were found to be independent predictors for PAD in ACS patients. Early in hospital mortality was seem to be dependent on clinical presentation, not on presence or absence of PAD.
To study the carotid intima media thickness in patients of fatty liver disease
Authors: Chouhan Mahendra , Kansal Archana , Trikha Sushma , Gupta Mayank 
Published: August 2017

Background: Fatty liver is associated with several atherosclerotic risk factors such as hypertension, diabetes and dyslipidemia. It has also been related to insulin resistance. This association was found in NIDDM patients as well as in non-diabetic subjects. An increased intima-media thickness (IMT) has been shown to be a risk factor for myocardial infarction and stroke. The aim of the present study is to investigate associations between hepatic steatosis and the risk of atherosclerosis.Methods: The present study was carried out on 88 patients of fatty liver disease and 80 controls in the department of General Medicine. An approximate equal number of age and sex matched persons without fatty liver were selected randomly as controls. Both fatty liver disease patients (i.e NAFLD and AFLD) and control group were further divided into two categories, one with risk factor for atherosclerosis and other without risk factors. Risk factors for atherosclerosis were taken according to ATP III guidelines.Results: When comparison of mean CIMT was done in NAFLD, AFLD and controls in a particular age group, significant difference was found in mean CIMT (both sides) in age group 40-49 yrs (p value 0.03, 0.002 for right and left respectively). The difference was also significant in mean CIMT of right in age group 18-24 yrs (p value 0.015) and in >60 years (p value 0.03). Among, NAFLD patients, for left mean CIMT p value was 0.0001, for right mean CIMT p value was 0.0001. Among AFLD patients, for left mean CIMT p value was 0.006 and for right mean CIMT p value was 0.0022. Only statistically significant difference was found in mean CIMT (left) in grade II fatty liver (p value 0.04). NAFLD and controls without risk factors for atherosclerosis, mean CIMT (both side) in NAFLD was found to be significantly more than control (p value 0.04). AFLD patients and controls without risk factors for atherosclerosis, mean CIMT of both side in AFLD patients was found to be significantly more than controls (p value for left CIMT 0.02 and for right CIMT 0.00001).Conclusions: CIMT was found to increase with advancing age in all three group i.e. NAFLD, AFLD and control group. CIMT was more in patients of fatty liver disease (both NAFLD and AFLD) having risk factor for atherosclerosis as compared to those without risk factors. Both NAFLD and AFLD are associated with increased CIMT in comparison to control group. As such all NAFLD and AFLD patients should be investigated for carotid atherosclerosis, as its early detection and management may be helpful in limiting the inherent complications of atherosclerosis.
Ensinar pela pesquisa: Porque não?
Authors: Otobelli Elisete Salvador , Dallacua Graziele , Zanatta Neiva 
Published: August 2017

Este trabalho descreve uma investigação realizada com professores de uma escola da rede pública estadual do Rio Grande do Sul que visou identificar se o método científico está ou não sendo utilizado como estratégia didática, qual a concepção dos professores sobre o valor do método científico e a importância do seu papel na construção do conhecimento. A desatenção e/ou a desmotivação de alguns alunos durante as aulas podem levar o professor a refletir sobre as alternativas para motivá-los e comprometê-los com seu aprendizado. Uma possibilidade é trabalhar a pesquisa científica como meio para que o aluno participe ativamente da sequência didática compartilhando dúvidas e descobertas. As Diretrizes Curriculares Nacionais orientam para que o processo ensino-aprendizagem seja ressignificado com a utilização da pesquisa como princípio pedagógico e o conhecimento científico faça parte do cotidiano escolar. A partir de trabalhos teóricos, ressalta-se a necessidade de o professor refletir sobre sua prática e avançar além da cópia e reprodução, adotando um ensino que privilegie a pesquisa, pressuposto para a emancipação intelectual do indivíduo. Assim, realizou-se uma avaliação diagnóstica com professores, onde os resultados apontam que a maioria dos professores não estudou o método científico na sua graduação, logo não o aplicam em sala de aula, apesar de considerá-lo importante para a aprendizagem. Diante destes resultados, os cursos de formação acadêmica, principalmente em licenciatura, precisam preparar satisfatoriamente o profissional para trabalhar com o método científico em sala de aula. Dessa forma o processo de ensino-aprendizagem não se limitará à cópia e reprodução, mas estará sustentado na formulação de perguntas e na procura por respostas. http://dx.doi.org/10.18226/23185279.v5iss1p26
Estudo do caso Klayman v. Zuckerberg and facebook: da liberdade de expressão ao discurso do ódio/Study of the case klayman v. zuckerberg and facebook: from freedom of speech to hate speech
Authors: Leal da Silva Rosane , Bolson Dalla Favera Rafaela 
Published: August 2017

Este artigo expõe e analisa o caso Klayman v. Zuckerberg and Facebook para, a partir dele, discutir temas atuais e controversos relacionados à colisão de direitos decorrentes das interações no site de rede social Facebook. Para tanto, foi utilizado o método de abordagem indutivo, tendo em vista que a pesquisa partiu da narrativa desse caso específico para depois tratar de assuntos gerais como a liberdade de expressão, notadamente a religiosa, verificando quando seu exercício excessivo pode configurar discurso do ódio. Já o método de procedimento empregado foi o monográfico, utilizado para selecionar e analisar o primeiro caso de discurso do ódio propagado no site de rede social Facebook, nos Estados Unidos, país que prioriza a liberdade de expressão em face aos demais direitos. Ainda que solução do caso seja adequada ao sistema jurídico estadunidense ela se mostra apartada da moderna teoria sobre os direitos humanos, que não atribui caráter absoluto a um direito quando em colisão com os demais. Ademais, o excesso no exercício da liberdade de expressão religiosa, ao derivar para a propagação do ódio e da violência não parece adequada aos valores do respeito e da dignidade da humana, essenciais para a convivência pacífica na sociedade em rede. AbstractThis paper exposes and analyzes the case Klayman v. Zuckerberg and Facebook for from it, discuss current and controversial issues related to the collision of rights arising from interactions on Facebook social networking site. Therefore, it was used the inductive approach method, given that the research came from the narrative of that particular case and then address general issues such as freedom of speech, notably religious, checking when excessive exercise can configure hate speech. The method of procedure employed was the monographic, used to select and analyze the first case of spread hate speech on Facebook social networking site, in the United States, which gives priority to freedom of speech in relation to other rights. Although if the solution is adequate to the American legal system, it shows apart from the modern theory of human rights, which does not give absolute character to the right when in collision with others. In addition, the excessive freedom of religious expression, to drift into the spread of hatred and violence does not seem adequate to the values of respect and dignity of the human, essential for peaceful coexistence in the network society. KeywordsHuman dignity; Hate speech; Klayman v. Zuckerberg and Facebook; Freedom of speech; Religion.
Conversão da ação individual em ação coletiva: análise do conteúdo do artigo 333 do CPC/2015, das razões do veto da presidente da república e do aproveitamento do instituto no atual sistema processual/ Conversion from individual in collective action: analysis of the content from the article 333 in CPC/2015, the reasons of the veto of the President of the Republic and the use of the institute on current procedural system
Authors: Cambi Eduardo , Fogaça Marcos Vargas 
Published: August 2017

O presente trabalho busca difundir o processo coletivo como instrumento para a melhoria da prestação jurisdicional. Também pretende a concretização das garantias constitucionais do direito processual brasileiro, corolários do devido processo legal coletivo, a partir de uma análise da conversão da ação individual em ação coletiva. Tal sugestão estava presente originalmente no artigo 333 do Código de Processo Civil de 2015 (NCPC), cuja inovação foi vetada pela Presidência da República. Para tanto, utiliza-se do método analítico de decomposição do instituto para analisar melhor cada especificidade. A conversão da demanda individual em demanda coletiva, prevista no texto vetado do NCPC, traria grandes conquistas a efetivação da justiça qualitativa, prestada de forma célere e efetiva. Assim, verifica-se a inconsistência do veto, uma vez que o instituto não estava mal disciplinado e permitia a convivência harmônica das técnicas de tutela coletiva de direitos com repercussão individual com as técnicas individuais de repercussão coletiva na sistemática processual civil brasileira. A partir da análise do incidente de coletivização, procura-se verificar em que medida tal instituto ainda pode ser aproveitado no atual sistema processual brasileiro.Palavras chave: Processo coletivo. Conversão da ação individual em ação coletiva. Veto ao Código de Processo Civil de 2015.AbstractThis study aims to spread the collective process as an instrument to the improvement of jurisdictional assistance and implementation of the constitutional principles of the Brazilian procedural law, corollaries of collective due process, on the basis of the analysis of conversion from individual in collective action, presents originally on article 333 of Civil Procedure Code of 2015, which was vetoed by the Presidency of the republic. Therefore, the analytical method of decomposition institute is used to better analyze each specificity. As the institute was regulated, the conversion from individual in collective action would bring great achievements to qualitative justice enforcement. Accordingly, there is inconsistency in Presidency’s veto, considering the institute wasn’t weak disciplined and there was the need for harmonious coexistence of rights collective protection techniques with individual techniques of collective repercussion on Brazilian civil procedure system.KeywordsCollective process. Conversion from individual in collective action. Veto on the Civil Procedure Code of 2015.
MENGURANGI GAP PERGURUAN TINGGI DENGAN DUNIA KERJA: UPAYA PENINGKATAN KUALITAS SUMBERDAYA MANUSIA
Authors: Fitri Agus Zaenul 
Published: August 2017

<p>The high capability for managing Higher Education (HE) is necessary which include adopting of modern management principles that focus on quality, continous improvement and customer satisfaction. Globalization era is competation era, so HE must based quality in any of its processed. The students of HE that still studying need a product of motivation and double communication that are; science, academic title, skill, experience, belief and good behaviour on the contex of balance. All of them need to work in workplace expected a better life in this world is systematic attempt to increase human resources quality. There are four points on education field, namely; average and opportunity of education, relevancy with development, quality and efficiency. Therefor HE needs to support a certain aim to increase their level lecturer qualification with next educational level or non-degree course in order to enhance a quality of human resources resulted automatically will support a quality of education at HE.</p><p><strong>Keywords</strong>: Gap, Pendidikan, Dunia Kerja, SDM</p>
KOMPENSASI SEBAGAI ALAT PENINGKATAN KINERJA DALAM BINGKAI AGENCY THEORY
Authors: Sulistiani Dwi 
Published: August 2017

<span><em>Agency theory looked at the relationship between the owner (the principal) and </em><span><em>management (agent). Compensation given to overcome problems in the theory of </em><span><em>agency, ie the difference between the interests of owners and agents. Compensation </em><span><em>system is designed organization aims to motivate employees to improve their </em><span><em>performance and retain competent employees. In order to work incentive</em><br /><span><em>compensation, corporate boards must choose a level measurement and precise </em><span><em>performance. Performance-based Reward twofold benefit: informing and </em><span><em>motivating.</em><br /><span><em>The purpose of this paper is to review how compensation as a performance </em><span><em>enhancement tool. The research method uses literature study and its conclusions </em><span><em>are: 1. The compensation was given to address the problems in the theory of </em><span><em>agency (the difference between the interests of owners and agents). 2. The </em><span><em>compensation system is designed organization aims to motivate employees to</em><br /><span><em>improve their performance and retain competent employees. 3. To work incentive </em><span><em>compensation, corporate boards must choose a level measurement and precise</em><br /><span><em>performance. The measurement system there are two traditional compensation (use </em><span><em>of accounting profit that measure the past) and the stock price (measuring the</em><br /><span><em>future).</em></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /><br class="Apple-interchange-newline" /></span>
URGENSI PELAYANAN PRIMA DALAM PENINGKATAN MUTU PEMBELAJARAN DI LEMBAGA PENDIDIKAN ISLAM
Authors: Yaqien Nurul 
Published: August 2017

<span class="fontstyle0">Every education institution especially Islamic education institution properly provides the best learning services in developing the effort of student quality. Services in education is an absolutely student needs, especially services in developing learning quality, moreover seeing the needs of competitive era. Student’s competence will compete with another competence both in own country and global world particularly in ASEAN region. To undertake the best services in every Islamic education institution, each circle academician of education needs to know the best service concepts. By knowing it that is expected all circle academicians could provide the optimal services for implementing qualified learning. The existence of qualified learning that expected to be able to make excellent generation in all aspects both in religion and general.<br /></span><span class="fontstyle2">Keyword: </span><span class="fontstyle0">Excellent Service, Quality Improvement, Learning</span>
PERGESERAN PARADIGMA SISTEM INFORMASI MANAJEMEN
Authors: Pramitha Devi 
Published: August 2017

<span class="fontstyle0">Management Information Systems (MIS) is a field that began to develop since the 1960s. Although there is no single consensus, it is generally defined as a driver's license system that provides information used to support the operation, management, and decisionmaking in organization. Prainformasional in the community, the people in it using a rigid paradigm assisted by intuition, the basis used by them to select the types of information needed is often not obvious because it is colored by the subjective nature of perception. But then in today's modern society, in addition to the paradigm shift that uses a creative<br />approach to merger, also using the scientific paradigm that enables the selection of information can be done quickly and accurately. In the world of education though, MIS become one of the important factors to improve services at the same time saving for education. With advances in the development of education in Indonesia, both from an<br />administrative or technological aspect, the process of education services in Indonesia should be done effectively and efficiently. Therefore, to develop the quality of education needed some support facilities, where one of the supporting facilities is the application of information technology in the field of Management Information Systems<br /></span><span class="fontstyle2">Keywords: </span><span class="fontstyle0">Management Information System, Paradigm Shift, Education</span>
Pengembangan Manajemen Berbasis Sekolah
Authors: Saefrudin Saefrudin 
Published: August 2017

<p><span class="fontstyle0">Education is an important part of the national development process that helps determine the economic growth of a country. Education is also an investment in human resource<br />development, where the improvement of skills and abilities is believed to be a factor supporting human efforts in navigating a life full of uncertainty. The variety of school environment conditions and the varied needs of students in the learning process coupled with Indonesia's highly complex geography, often can not be fully appreciated by the central bureaucracy. Therefore, in the process of improving the quality of education needs to find an alternative model of school management. This led to the birth of the concept of school-based quality improvement management. The purpose of this discussion is to describe the concept of management in accordance with<br />the needs of schools.</span></p><p><span class="fontstyle2">Key Word: </span><span class="fontstyle0">Development, School Based Management</span></p>