bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAPPING AND PROTECTING THE INTELLECTUAL PROPERTY RIGHT IN THE FIELD OF THE TRADITIONAL BATIK DESIGN OF TIRTOMOYO AS THE CULTURAL HERITAGE AND ITS DEVELOPMENT BASED ON THE LOCAL GENIUS IN THE CREATIVE INDRUSTRIAL ERA
Authors: - Sarwono 
Published: April 2017

<p align="center"><strong><em>Abstract</em></strong></p><p><em> In order to provide the protection to the “traditional batik art knowledge” in Tirtomoyo, Wonogiri, the local government policy rests on the </em><em>potensial of art, commerce, services, education, tourism and sports</em><em>.Here, it can be drawn the real purpose, that is to develop, to conserve, and to protect the traditional knowledge as the heritage and cultural expression, especially the traditional knowledge. I</em><em>n th</em><em>is</em><em> case</em><em>, the Intellectual Property Right protection and its all varieties should be applied on the traditional intellectual art. However, it has not yet manifested the regional regulation on the Intellectual Property Right, especially the protection to the traditional knowledge. There has not been confirmation about what institutions will be responsible or what kind of agencies will be involved in providing the protection to the traditional knowledge, like the batik art, dance art, and others, so that they don’t seem loose accountability in handling it. The policy on the Intellectual Property Right, especially the one related to the traditional knowledge, is still partial or supplement. The Industry and Trade Department of Wonogiri regency, which handles the micro and medium industry field and is not related directly to the batik handicraft industry, has planned to make a program of batik handicraft industry as the regional superior. </em></p><strong><em>Key words: Intellectual Property Right, Traditional knowledge, Batik Art.</em></strong>
AN EVALUATION OF LEGAL POLICY RELATED TO THE IMPLEMENTATION OF THE SIMULTANEOUS LOCAL ELECTION (FIRST PERIOD OF THE SIMULTANEOUS LOCAL ELECTION)
Authors: Riwanto Agus 
Published: April 2017

<p align="center"><strong><em>Abstract</em></strong></p><p><em>Indonesia legal policy of</em><em> the simultaneous local election to appoint a district head had been </em><em>amended by Law Number 8 of 2015 concerning the local election (governors, regents and mayors) from the regular models to the simultaneous models. Simultaneous local election will be implemented in periods, namely a first period in 2015, a second period in 2017, a third and fourth period will be approximately held from 2018 to the 2021, and a national simultaneous local</em><em> elections will be held in</em><em> 2027. The simultaneous local election is aimed to make the efficiency and effectiveness of the budget, time and labor organizer; to eliminate boredom voters; to increase public control. Law Number 8 of 2015 had been reviewed judicially thirdty first times. The Constitutional Court also issued a surpprised decision which change a political constellation of Indonesia. The political aspect of simultaneous local election in 2015 need to be fixed through the revision of Law Number 8 of 2015 in order to create the system of the simultaneous elections fairly and democratically for the implementation of the next period: the required transfer of election financing from the budget to the state budget; the need to create a model for the preliminary election; restrictions on candidacy requirements; a dispute settlement of the simultaneous local election to the supreme court; a time restrictions on the election administration disputes lawsuit in the Administrative Court; and we need to build a model of election law enforcement system integration.</em></p><p><strong><em>Key Word</em></strong><em>: legal policy evaluation, simultaneous local election</em></p>
Congratulatory Message
Authors: Altintas Yusuf ,   Professor Dr., Manufacturing Automation Laboratory, Department of Mechanical Engineering, The University of British Columbia
Published: April 2017

International Journal of Automation Technology (IJAT) was initiated by Prof. Takeuchi to fill the gap between manufacturing and its application in the presently automated factories ten years ago. The journal has received strong record of submissions which have passed through rigorous review process by highly established academics in the field. As a result, IJAT has become one of the key journals to disseminate research results from traditional manufacturing processes to most advanced nano-micro manufacturing, smart actuators, robots, micro-manipulators, control methods, and a number of key automation applications.
The Editors-in-Chief Prof. Takeuchi, associate editors, and editorial officer Mr. Wakai for the outstanding efforts which brought the journal to a world class level in past ten years. We appreciate all authors who contributed to the journal with their articles which made the journal successful.
Yusuf Altintas
October 31, 2016
DAKWAH RETORIS DALAM KARYA SASTRA NOVEL “HABIBIE & AINUN” KARYA BJ. HABIBIE
Authors: Rahmah Mariyatul Norhidayati 
Published: April 2017

<p>There should be at least four rethorical principles in conducting da’wah. The first principle is an emotional appeal, which means a kind of touching da’wah communication that involves emotions, expectation and affection of the mad’u. Secondly, the da’i (preacher) should use persuasive and gently ways as well as clear and understandable languages. Thirdly, he should understand the condition of community so his da’wah could become soothing. The last principle is enabling to give strong arguments. The novel might become a medium to deliver the messages of da’wah. The novel of Habibie &amp; Ainun does not only a philological and romance novel, but also a kind of cultural, political and da’wah novel. Its feature is not only in using rhetorical language, but indeed it was also written based on personal stories including his life experiences and love story of a religious man that tremendously inspires the readers. In this novel, the rhetorical da'wah is expressed in various ways following the context of life journey as well as the writer’s mood and passion namely kinds of persuasive and touching da’wah, contextual da’wah, and argumentative rethorical da’wah.</p><p align="center"><strong>***</strong></p><p>Prinsip Retorika dalam berdakwah paling tidak mengandung empat hal: emotional appeals (imbauan emosional) yakni sebuah tindak komunikasi dakwah yang menyentuh hati sasaran dakwah, melibatkan emosi, harapan dan kasih sayang;menggunakan bahasapersuasive, lemah lembut, jelas, dan mudah dipahami; memahami kondisi masyarakat sehingga mengarah pada dakwah yang menyejukkan hati; dan disertai dengan argumentasi yang kuat. Novel dapat digunakan sebagai media untuk menyampaikan pesan-pesan dakwah.Novel Habibie &amp; Ainun, bukan hanya novel sastra dan novel cinta, tetapi juga novel budaya, politik dan novel dakwah.Dan keistimewaan Novel Habibie &amp; Ainun ini disamping bahasanya yang retoris, adalah lebih dari sekedar sebuah cerita, novel ini ditulis oleh pengarangnya berdasarkan kisah pribadi, apa yang terjadi dalam hidupnya, sebuah kisah cinta insan beriman yang memberi insprirasi yang luar biasa bagi pembaca. Dakwah retoris dalamnovel ini terpancar dalam berbagai bentuk mengiringi situasi perjalanan hidup, kejiwaan dan emosi sang penulis, ada dakwah retoris menyentuh hati, persuasive, memperhatikan kondisi sasaran dakwah hingga retorika argumentatif.</p>
Productivity and Cost Analysis of Forest Harvesting Operation in Matang Mangrove Forest, Perak, Malaysia
Authors: Tindit Albert Empawi , Gandaseca Seca , Nyangon Laurna , Pazi Ahmad Mustapha Mohamad 
Published: April 2017

Matang Mangrove Forest is under systematic management since 1902 and still considered as the best managed mangrove forest in the world. This research was conducted to measure the time and productivity of forest harvesting operation and also to analyze the cost and revenue of mangrove forest harvesting operation at Matang mangrove forest. This project had been carried out in cooperation with Seri Sepetang Enterprise, one of the harvesting licenses in Kuala Sepetang, Perak. Data collections were taken in every station starting from standing tree until to the Kiln-Drying jetty. The data then calculated by using the formulas of productivity and cost analysis. As the result, the productivity for felling, bucking and debarking, the manual skidding using wheel-barrow and the water transportation are 1.84 tan/hour, 3.82 tan/hour and 4.64 tan/hour respectively. The cost for each operation of 9 tan log volume for felling, bucking and debarking, the manual skidding using wheel-barrow and the water transportation are RM 56.88, RM 10.80 and RM 36.72 respectively. As the revenue, the company paid RM 260 per 9 tan of log for the in-forest operation (felling, manual skidding and loading to the ship) and pay RM 80 per 9 tan for the water transportation, and they gained the net profit of RM 192.32 and RM 43.28 respectively. The average of forest harvesting operation is twice operation in a day (equal with 2 x 9-ton volume of log production a day), so they will gain a double profit. In conclusion, the forest harvesting operation is sustainably managed for supplying the raw material of charcoal industries in Matang mangrove forest. Since, they work manually and spend much energy in this forest harvesting operation, so for further study it recommends to conduct the ergonomics evaluation during forest harvesting operation at Matang Mangrove Forest.
Effect of Doxycycline on Epithelial-Mesenchymal Transition via the p38/Smad Pathway in Respiratory Epithelial Cells
Authors: Shin Jae-Min , Kang Ju-Hyung , Lee Seoung-Ae , Park Il-Ho , Lee Heung-Man 
Published: April 2017

Purpose Doxycycline has antibacterial and anti-inflammatory effects, and it also suppresses collagen biosynthesis. This study aimed to confirm the effects and mechanism of doxycycline on transforming growth factor (TGF) beta 1 induced epithelial-mesenchymal transition and cell migration in A549 and primary nasal epithelial cells. Methods A 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay and phalloidin-fluorescein isothiocyanate staining were used to evaluate cytotoxicity and cellular morphologic changes. Western blot and immunofluorescence staining were used to determine the expression levels of E-cadherin, vimentin, alpha-smooth muscle actin, fibronectin, phosphorylated Smad2/3, and mitogen-activated protein kinases. Scratch and transwell migration assays were used to assess cellular migration ability. Results Doxycycline (0-10 μg/mL) had no significant cytotoxic effects in A549 and primary nasal epithelial cells. Increased expression of mesenchymal markers, including vimentin, alpha-smooth muscle actin, and fibronectin in TGF beta 1 induced A549 cells were downregulated by doxycycline treatment. In contrast, E-cadherin expression was upregulated in TGF beta 1 induced A549 cells. An in vitro cell migration assay showed that doxycycline also inhibited the ability of TGF beta 1 induced migration. Doxycycline treatment suppressed the activation of Smad2/3 and p38, whereas its inhibitory effects were similar to each element-specific inhibitor in A549 and primary nasal epithelial cells. Conclusion Doxycycline inhibited TGF beta 1 induced epithelial-to-mesenchymal transition and migration by targeting Smad2/3 and p38 signal pathways in respiratory epithelial cells.
Excavating Meningoencephaloceles: A Newly Recognized Entity
Authors: Loftus Patricia A. , Wise Sarah K. , Daraei Pedram , Baugnon Kristen , DelGaudio John M. 
Published: April 2017

Background Spontaneous cerebrospinal fluid (CSF) leaks are largely attributed to idiopathic intracranial hypertension and typically present as skull base defects with or without prolapse of intracranial contents. However, in our practice, we have encountered a distinct type of spontaneous CSF leak that presents in a different manner. Objective To discuss a newly-classified, difficult to treat, subset of spontaneous CSF leaks that present as excavation of the bone of the skull base in a tunnel- or canal-like fashion by a meningocele or meningoencephalocele instead of as a localized area of bony dehiscence. Methods A retrospective review was performed at a tertiary care rhinology practice to identify a subset of CSF leak patients with an excavating/canal-like skull base defect visualized radiographically on computed tomography (CT) scan or magnetic resonance imaging and/or endoscopically in the operating room. Results The cohort of patients consisted of 7 females and 1 male with an average age of 53.6 years and a self-reported race of 4:3:1 African-American: Caucasian-Indian. All patients presented with CSF rhinorrhea. The most common leak site was the cribriform and upper septum. Six of the 8 patients had multiple defects and/or progression of their skull base defects, and 5 patients required multiple and/or repeat repairs in the operating room. Seven of the 8 patients underwent a cisternogram because the excavating nature of the leaks made it difficult to identify the specific leak site on high-resolution CT scan alone. Conclusion In spontaneous CSF leaks that are difficult to identify or recur soon after a proper repair, an excavating pattern should be considered. Failure to recognize this type of leak and all of its tributaries, to fully unroof the excavated bone to completely resect the meningocele, and to visualize and close the site of origin will likely result in failure and recurrence of CSF leak.
Normal Saline Solution Nasal-Pharyngeal Irrigation Improves Chronic Cough Associated with Allergic Rhinitis
Authors: Lin Lin , Chen Zhongchun , Cao Yitan , Sun Guangbin 
Published: April 2017

Background Upper airway inflammation is one of the most commonly identified causes of chronic cough, although the underlying mechanism is not clear. This study compared normal saline solution nasal-pharyngeal irrigation (NSNPI) and fluticasone propionate nasal spray (FPNS) treatment for chronic cough associated with allergic rhinitis (AR). Methods Patients with suspected AR to house-dust mite were enrolled, and the symptom of cough was assessed by a cough symptom score and the Leicester Cough Questionnaire, and cough response to capsaicin was evaluated. AR was assessed by using the visual analog scale (VAS) and the Mini Juniper Rhinoconjunctivitis Quality of Life Questionnaire (MiniRQLQ). Mediators, including histamine, leukotriene C4, and prostaglandin D2, and the major basic protein from nasal lavage fluid (NLF) were examined. The patients were treated with NSNPI (the NSNPI group) or FPNS (the FPNS group) for 30 days, after which they were reassessed. Results Forty-five of 50 patients completed this study. The scores of the cough symptom and the Leicester Cough Questionnaire, and the capsaicin cough threshold all improved statistically after NSNPI but did not change after FPNS. There were statistically significant changes in the evaluations of the MiniRQLQ and the mediators, including histamine and leukotriene C4, in the NLF in the NSNPI group. However, significant changes were found in the assessments of VAS, MiniRQLQ, and all above mediators including histamine, leukotriene C4, and prostaglandin D2, and the major basic protein in the NLF of the FPNS group. Furthermore, the assessments of VAS and all the mediators were reduced more in the FPNS group compared with those in the NSNPI group. Conclusion The patients with suspected AR to house-dust mite reported a better relief of the cough symptom after 30 days of treatment with NSNPI compared with that after nasal corticosteroid.
Nitric Oxide Production is Stimulated by Bitter Taste Receptors Ubiquitously Expressed in the Sinonasal Cavity
Authors: Yan Carol H. , Hahn Samuel , McMahon Derek , Bonislawski David , Kennedy David W. , Adappa Nithin D. , Palmer James N. , Jiang Peihua , Lee Robert J. , Cohen Noam A. 
Published: April 2017

Background Bitter taste receptors (T2R) have recently been demonstrated to contribute to sinonasal innate immunity. One T2R, T2R38, regulates mucosal defense against gram-negative organisms through nitric oxide (NO) production, which enhances mucociliary clearance and directly kills bacteria. To determine whether additional T2Rs contribute to this innate defense, we evaluated two other sinonasal T2Rs (T2R4 and T2R16) for regulation of NO production and expression within the human sinonasal cavity. Methods Primary human sinonasal cultures were stimulated with ligands specific to T2R4 and T2R16, colchicine and D-salicin, respectively. Cellular NO production was measured by intracellular 4-amino-5-methylamino-2’, 7′-difluorofluorescein diacetate fluorescence. For T2R expression mapping, sinonasal tissue was obtained from patients who underwent sinus surgery of the middle turbinate, maxillary sinus, ethmoid sinus, or sphenoid sinus. The expression of T2R4, T2R16, and T2R38 was evaluated by using immunofluorescence with validated antibodies. Results Similar to T2R38, T2R4 and T2R16 trigger NO production in a dose-dependent manner by using the canonical taste signaling pathway in response to stimulation with their respective ligands. All three receptors were expressed in the cilia of human epithelial cells of all regions in the sinonasal cavity. Conclusion These three T2Rs signaled through the same NO-mediated antimicrobial pathway and were ubiquitously expressed in the sinonasal epithelium. Additional T2Rs besides T2R38 may play a role in sinonasal immune defense. Mapping of T2R expression demonstrated the potential widespread role of T2Rs in sinonasal defense, whereas the genetics of these T2Rs may contribute to our understanding of specific endotypes of chronic rhinosinusitis and develop into novel therapeutic targets.
Predictive performance of the American College of Surgeons universal risk calculator in neurosurgical patients
Authors: Vaziri Sasha , Wilson Jacob , Abbatematteo Joseph , Kubilis Paul , Chakraborty Saptarshi , Kshitij Khare , Hoh Daniel J. 
Published: April 2017

OBJECTIVEThe American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) universal Surgical Risk Calculator is an online decision-support tool that uses patient characteristics to estimate the risk of adverse postoperative events. Further validation of this risk calculator in the neurosurgical population is needed; therefore, the object of this study was to assess the predictive performance of the ACS NSQIP Surgical Risk Calculator in neurosurgical patients treated at a tertiary care center.METHODSA single-center retrospective review of 1006 neurosurgical patients treated in the period from September 2011 through December 2014 was performed. Individual patient characteristics were entered into the NSQIP calculator. Predicted complications were compared with actual occurrences identified through chart review and administrative quality coding data. Statistical models were used to assess the predictive performance of risk scores. Traditionally, an ideal risk prediction model demonstrates good calibration and strong discrimination when comparing predicted and observed events.RESULTSThe ACS NSQIP risk calculator demonstrated good calibration between predicted and observed risks of death (p = 0.102), surgical site infection (SSI; p = 0.099), and venous thromboembolism (VTE; p = 0.164) Alternatively, the risk calculator demonstrated a statistically significant lack of calibration between predicted and observed risk of pneumonia (p = 0.044), urinary tract infection (UTI; p < 0.001), return to the operating room (p < 0.001), and discharge to a rehabilitation or nursing facility (p < 0.001). The discriminative performance of the risk calculator was assessed using the c-statistic. Death (c-statistic 0.93), UTI (0.846), and pneumonia (0.862) demonstrated strong discriminative performance. Discharge to a rehabilitation facility or nursing home (c-statistic 0.794) and VTE (0.767) showed adequate discrimination. Return to the operating room (c-statistic 0.452) and SSI (0.556) demonstrated poor discriminative performance. The risk prediction model was both well calibrated and discriminative only for 30-day mortality.CONCLUSIONSThis study illustrates the importance of validating universal risk calculators in specialty-specific surgical populations. The ACS NSQIP Surgical Risk Calculator could be used as a decision-support tool for neurosurgical informed consent with respect to predicted mortality but was poorly predictive of other potential adverse events and clinical outcomes.
Marking 15 years of the Genetic and Rare Diseases Information Center
Authors: Lewis Janine , Snyder Michelle , Hyatt-Knorr Henrietta 
Published: April 2017

BACKGROUND: The Genetic and Rare Diseases Information Center (GARD), a program of the National Center for Advancing Translational Sciences, was established in 2002 to assist the public in finding reliable, timely, and easy-to-understand information about genetic and/or rare diseases in English or Spanish. OBJECTIVE: A review of longitudinal data on GARD inquiries from 2002 to 2016 and assessment of the results of two user satisfaction surveys were conducted to understand the demographics and needs of GARD customers over time. METHODS: Since 2002, GARD has collected anonymized data while responding to questions received via e-mail, website, telephone, fax, letter, or TTY. Between 2002 and 2016 GARD received a total of 60,106 inquiries. User satisfaction surveys were conducted in 2006 and 2014, in which users self-selected to participate. RESULTS: The annual number of inquiries has risen steadily since 2002. Inquiries are overwhelmingly from educated female patients, family, and friends seeking disease-specific information, treatment options, referrals, and research studies. Most users report satisfaction with the experience. CONCLUSIONS: Rare disease patients and their families face challenges in finding information about their symptoms or diagnosis, prognosis, treatment options, significance for family members, and research opportunities. Lack of available clinical expertise can leave patients, their family, and friends with little choice but to become knowledgeable on their own. GARD fills a critical need by providing the public with vetted, evidence-based information that empowers people to engage in their own health care and seek research studies of relevance.
Boosting Quality Registries with Clinical Decision Support Functionality
Authors: Wannheden Carolina , Hvitfeldt-Forsberg Helena , Eftimovska Elena , Westling Katarina , Ellenius Johan 
Published: April 2017

Summary
Background: The care of HIV-related tuberculosis (HIV/TB) is complex and challenging. Clinical decision support (CDS) systems can contribute to improve quality of care, but more knowledge is needed on factors determining user acceptance of CDS.
Objectives: To analyze physicians’ and nurses’ acceptance of a CDS prototype for evidence-based drug therapy recommendations for HIV/TB treatment.
Methods: Physicians and nurses were involved in designing a CDS prototype intended for future integration with the Swedish national HIV quality registry. Focus group evaluation was performed with ten nurses and four physicians, respectively. The Unified Theory of Acceptance and Use of Technology (UTAUT) was used to analyze acceptance.
Results: We identified several potential benefits with the CDS prototype as well as some concerns that could be addressed by redesign. There was also concern about dependence on physician attitudes, as well as technical, organizational, and legal issues.
Conclusions: Acceptance evaluation at a prototype stage provided rich data to improve the future design of a CDS prototype. Apart from design and development efforts, substantial organizational efforts are needed to enable the implementation and maintenance of a future CDS system.