bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link?
Authors: Pani Fabiana , Massidda Matteo , Pusceddu Valeria , Puzzoni Marco , Massa Elena , Madeddu Clelia , Scartozzi Mario , Mariotti Stefano 
Published: May 2017

Objective
Thyroid dysfunction has been reported during Regorafenib (Reg) administration, but no detailed study is presently available.

Design
Prospective, observational cohort study. Patients with documented metastatic colorectal cancer and progression of disease during or within 3 months after the last standard therapy, with no evidence and history of previous thyroid disease were enrolled.

Methods
Twenty-five consecutive patients were evaluated before and 8–50 weeks after initiating Reg therapy by monthly clinical, ultrasound and laboratory (thyrotropin (TSH), free thyroxine (fT4), antithyroglobulin (TgAb) and antithyroid peroxidase (TPOAb)) evaluation.

Results
Thirteen/25 patients (52%) became hypothyroid (TSH: 12.5 ± 4.01 IU/L, range: 4.6–22.0) within 5 months of therapy. TPOAb became detectable (99–155 IU/mL) in 2/25 (8%) patients. Thyroid volume progressively decreased (from 8.6 ± 2.2 mL to 4.9 ± 2.4 mL after 5 months of Reg therapy, P < 0.0001). The progression-free survival (PFS) was longer in patients developing hypothyroidism (43 weeks) than in those remaining euthyroid (17 weeks, P < 0.01). Fatigue (the most common general serious Reg adverse event) was associated with hypothyroidism severity and reversed after levothyroxine therapy (L-T4).

Conclusions
Reg rapidly causes hypothyroidism in about 50% of patients and in a minority of them also triggers thyroid autoimmunity. Reg-induced hypothyroidism was strictly related to fatigue, easily reversed by L-T4 administration and associated to longer survival. These results suggest that prompt recognition of hypothyroidism in patients with severe fatigue may prevent unnecessary Reg dose reduction or withdrawal.
La ética en la investigación de posgrado
Authors: Piña-Osorio Juan Manuel , Aguayo-Rousell Hilda Berenice 
Published: May 2017

This article presents the results of an exploratory-descriptive research with empirical referents. The objective was to document, systematize and evaluate some features of 15 postgraduate theses in education, with the intention to make visible some recurring dishonest practices of students and teachers. The postgraduate programs from which the theses were obtained are located in the metropolitan area of Mexico City. The selection of documents was carried out between July and November 2015. Two Likert scales were used to assess two dimensions separately: 1) content, in which originality, congruence, dominance and relevance of authors, findings and relevant conclusions were considered; and 2) presentation, which examined style, logical structure, spelling and punctuation, citations, references and sources of information. Each indicator was assigned a numerical value and this one was given an evaluative characteristic: 5: excellent, 3: regular and 1: deficient. Subsequently, percentages were obtained. The results indicated that only a third of the theses could be classified as excellent for the quality of the content and the impeccable presentation; a similar percentage were works that fulfilled the necessary but didn’t count with the rigor and originality of the first ones. The remaining papers had serious deficiencies, both in content and in the formal presentation of the document, without achieving the minimum quality demanded by a postgraduate thesis. The analysis of these investigations made it possible to visualize some of the dishonest practices of people graduating from various educational programs and the lack of commitment to their research. The results about the quality of the research in various doctoral programs indicate that there is little responsibility in students, personal tutor and the reviewer. The results allow the authorities of each program to observe the problem and seek practical solutions to solve it.
Aprendizaje autorregulado en el nivel universitario: Un estudio situado con estudiantes de psicopedagogía de diferentes ciclos académicos
Authors: Ventura Ana Clara , Cattoni María Soledad , Borgobello Ana 
Published: May 2017

Being able to properly regulate one’s own learning positively impacts student’s academic performance. Hence the relevance of understanding what they are, how they articulate, and how they change learning strategies and motivation patterns across academic training. Our aims are: (a) to describe cognitive / metacognitive learning strategies and motivation patterns used by students (mean and standard deviation); (b) to analyze the correlations between both groups of variables (Pearson’s index correlation); (c) to compare above results according to the basic level (1st year) and the higher level (5th year) of academic training (Student’s t test). The quantitative ex post facto study was based on the Argentine version of the MSLQ (Motivated Strategies Learning Questionnaire), also called MSLQe; it was applied to 114 students of Psychopedagogy. The results showed the following: (a) a varied repertoire of learning strategies and motivation patterns; (b) a greater use of metacognitive strategies for self-regulation, as well as of strategies for time and study environment management, was associated with higher levels of motivational patterns of goal orientation, task assessment, control beliefs, and self-efficacy of students; (c) statistical differences according to the academic cycle: in favor of the students who were beginners in cognitive strategies of review, metacognitive self-regulation, and organization; while the scores were higher for the advanced students in relation to critical thinking. Likewise, regarding the motivation patterns, the advanced students showed more tendencies towards intrinsic orientation goals, whereas the beginners did it in extrinsic motivation goals, beliefs of control and of self-efficacy, and anxiety. It is possible to conclude that the academic formation made possible a hierarchical integration of both superficial and deep strategies, as well as internal and external motivation patterns of the students. Thus, this article contributes to an analysis of cognitive dimensions (cold and warm), as contextually situated (initial and final levels of academic formation), of the learning strategies and motivation patterns of university students.
Komplex nyaki és agyi érpatológia endovascularis kezelése
Authors: Oláh Csaba , Czabajszki Máté , Lázár István 
Published: May 2017

Abstract: Authors present complex multistage endovascular treatment of female patient with an intradural infiltrative, inoperable tumor of the glomus jugulare, a stenosis of the internal carotid artery and an aneurysm of middle cerebri artery. In the literature our case report is the first announcement in which three pathology coexist ipsilateral in one patient and the patient has been treated step by step by endovascular procedures. Beside the endovascular treatment steps they display glomus jugulare tumor’s symptoms, staging, treatment options and also the current treatment guidelines of internal carotid artery stenosis and intracranial aneurysms. Orv Hetil. 2017; 158(18): 706–710.
Protecting Ecosystems by way of Biological Control: Cursory Reflections on the Main Regulatory Instruments for Biological Control Agents, Present and Future
Authors: Albert Reece , Moolman Jurie 
Published: May 2017

Although there are numerous threats to ecosystems and the resultant ecosystem services, alien and invasive plants (AIP) have been identified as being one of the major causes of ecosystem destruction. In addressing the threat of alien and invasive plants through the use of various mechanisms, the regulatory framework imposed by legislation is key in ensuring that that controlling AIPs does in fact not do more harm than good. One such control mechanism, which has the potential to do wonders or wreak havoc if not adroitly implemented, is that of using biological control agents. This contribution provides a brief overview on the three main regulatory instruments used to control biological control agents in South Africa, namely the Conservation of Agricultural Resources Act 43 of 1983, the Agricultural Pests Act 36 of 1983 and the National Environmental Management: Biodiversity Act 10 of 2004. It also considers possible future developments on the regulation of biological control agents.
Learning Analytics focused on student behavior. Case study: dropout in distance learning institutions
Authors: Aguilar Jose , Riofrío Guido , Encalada Eduardo 
Published: May 2017

Abstract:
Normally, Learning Analytics (LA) can be focused on the analysis of the learning process or the student behavior. In this paper is analyzed the use of LA in the context of distance learning universities, particularly focuses on the students’ behavior. We propose to use a new concept, called "Autonomic Cycle of Learning Analysis Tasks", which defines a set of tasks of LA, whose common objective is to achieve an improvement in the process under study. In this paper, we develop the "Autonomic Cycle of LA Tasks" to analyze the dropout in distance learning institutions. We use a business intelligence methodology in order to develop the "Autonomic Cycle of LA Tasks" for the analysis of the dropout in distance learning. The Autonomic Cycle identifies factors that influence the decision of a student to abandon their studies, predicts the potentially susceptible students to abandon their university studies, and define a motivational pattern for these students.
Spanish Abstract:
Normalmente, La Análitica del Aprendizaje puede enfocarse en el análisis del proceso de aprendizaje, o en el análisis del comportamiento del estudiante. En este artículo se analiza el uso de LA en el contexto de las universidades a distancia, centrándonos particularmente en el comportamiento de los estudiantes. Para ello, proponemos utilizar un nuevo concepto, llamado "Ciclo Autonómico de Tareas de Análitica del Aprendizaje", que define un conjunto de tareas de LA, cuyo objetivo común es lograr una mejora en el proceso bajo estudio. En este artículo se desarrolla el "Ciclo Autonómico de Tareas LA" para analizar la deserción estudiantil en las instituciones de educación a distancia. Para ello, utilizamos una metodología de inteligencia de negocios con el fin de desarrollar dicho ciclo para el análisis de la deserción en el aprendizaje a distancia. El Ciclo Autonómico identifica factores que influyen en la decisión del estudiante de abandonar sus estudios universitarios, predice los estudiantes potencialmente susceptibles a desertar, y define un patrón de motivación para estos estudiantes.
Stratégies d’adaptation des éleveurs bovins laitiers en zone montagneuse d’Algérie
Authors: Mouhous A. , Alary V. , Huguenin J. 
Published: May 2017

La production laitière peut constituer une part importante des revenus dans les exploitations de montagne en Kabylie. Nos travaux ont porté sur la caractérisation des élevages bovins dans cette zone, leur mode de conduite et les stratégies adoptées. Suite à un travail antérieur sur 97 élevages, nous avons procédé à un suivi de 17 exploitations de mars 2012 à février 2013. L’étude a permis d’identifier trois types d’exploitations : a) les petites exploitations (< 8 unités de gros bétail [UGB] en moyenne) produisant principalement de la viande (type « viande ») ; b) les exploitations moyennes (12 UGB) à dominance laitière (type « lait ») ; et c) les grandes exploitations (> 46 UGB) avec une production mixte de lait et de viande (type « mixte »). L’alimentation des vaches a été basée sur du concentré toute l’année, en moyenne 8 kg/vache/ jour pour les deux premiers types d’exploitations et jusqu’à 11 kg/vache/jour pour le troisième. La vente annuelle de lait par vache a été de 3 000 kg environ pour le type viande, et de 4 000 kg pour les types lait et mixte. Les revenus des exploitations spécialisées (viande ou lait) ont été similaires (moins de 400 000 dinars algériens [DZD] par an, soit 3 896 €), alors que le type mixte a généré des revenus supérieur à 3 millions de DZD/an (soit 33 139 €). L’étude a montré que les stratégies adoptées dépendaient beaucoup de la capacité des éleveurs à obtenir des dotations. Elle permet de mieux appréhender les dynamiques actuelles des systèmes d’élevage en zone montagneuse, selon leurs atouts et leurs faiblesses.
Intervenções Psicológicas na Perturbação Borderline da Personalidade: Uma Revisão das Terapias de Base Cognitivo-Comportamental
Authors: Marques Sofia , Barrocas Daniel , Rijo Daniel 
Published: May 2017

Introdução: A perturbação borderline da personalidade é a perturbação da personalidade mais comum, ocorrendo em 1,6 a 6% da população geral. É caraterizada por instabilidade nos afetos e impulsividade, havendo um elevado número de comportamentos autolesivos e consumo de recursos de saúde. A psicoterapia é recomendada por várias diretrizes internacionais, como sendo a abordagem terapêutica primária desta patologia. Neste trabalho efetuou-se uma revisão dos efeitos e da eficácia das intervenções psicoterapêuticas de base cognitivo-comportamental no tratamento da perturbação borderline da personalidade.Material e Métodos: Revisão bibliográfica, através da Medline e PubMed, utilizando como palavras-chave: ‘borderline personality disorder’, ‘cognitive-behavioral therapy’, ‘efficacy’.Resultados: Foram incluídos 16 ensaios clínicos aleatorizados que avaliaram a eficácia de diversas intervenções psicoterapêuticas de base cognitivo-comportamental, nomeadamente da terapia comportamental-dialética, terapia cognitivo-comportamental, terapia focada nos esquemas e terapia cognitiva por manual. Todas as intervenções psicoterapêuticas analisadas demonstraram benefícios clínicos, quer ao nível da redução da psicopatologia geral e específica da perturbação borderline da personalidade, quer ao nível comportamental, com redução da frequência e gravidade dos comportamentos autolesivos, e com melhoria do funcionamento social, interpessoal e global. Foi observada uma taxa de remissão diagnóstica elevada com terapia comportamental-dialética (57%) e terapia focada nos esquemas (94%).Discussão: Apesar de existirem diferenças entre as intervenções psicoterapêuticas analisadas, todas apresentaram benefícios clínicos no tratamento da perturbação borderline da personalidade. A terapia comportamental-dialética e a terapia focada nos esquemas foram as intervenções que apresentaram uma maior robustez científica na documentação da sua eficácia, porém ambas são terapias integrativas de base cognitivo-comportamental que se afastam do modelo cognitivo-comportamental tradicional.Conclusão: Os resultados dos vários ensaios clínicos comprovam a eficácia das terapias de base cognitivo-comportamental no tratamento da perturbação borderline da personalidade. Contudo, a evidência científica é ainda parca e carece de estudos de elevado rigor metodológico que corroborem estes resultados.
ALTERNATIF PENYELESAIAN SENGKETA WILAYAH LAUT INDONESIA-MALAYSIA
Authors: Satriyo Kusumo Ayub Torry , Leksono Handojo 
Published: May 2017

<p align="center"><strong>A</strong><strong>b</strong><strong>s</strong><strong>t</strong><strong>rac</strong><strong>t</strong></p><p><em>T</em><em>his study discusses alternative resolutions on maritime boundary dispute between Indonesia and Malay- sia. It was based on a legal research, which used statutes and case approach. The research materials were collected by literature study and analyzed by applying the interpretation analysis technique.T</em><em>he result shows that the alternative resolutions of Indonesia-Malaysia border dispute can be carried out through several mechanisms. First, by referring to the UNCLOS 1982, through Bilateral Mutual Agreement on drawing an equidistant line using the equity principle and considering relevant circumstances. Second, by means of ASEAN; and third, by means of International Court of Justice mechanism regarding the equitable principle and relevant circumstances.</em></p><p><strong><em>Keywords: </em></strong><em>the outermost islands, border management, maritime dispute settlement, archipelagic state</em></p><p> </p><p align="center"><strong>A</strong><strong>B</strong><strong>S</strong><strong>T</strong><strong>R</strong><strong>A</strong><strong>K</strong></p><p>Penelitian ini membahas alternatif penyelesaian sengketa batas maritim antara Indonesia dan Malaysia. Kajian ini berdasarkan penelitian hukum dengan menggunakan pendekatan undang-undang dan pendekatan kasus. Pengumpulan bahan hukum melalui studi kepustakaan dan dianalisis dengan teknik analisis interpretasi hukum. Hasil pembahasan menunjukkan alternatif penyelesaian sengketa batas wilayah Indonesia-Malaysia dapat dilakukan dengan beberapa cara. <em>Pertama</em>, mengacu pada UNCLOS 1982 melalui <em>Bilateral Mutual </em><em>Agree- ment </em>dalam menarik garis sementara yang menggunakan prinsip sama jarak dan mempertimbangkan faktor yang relevan, <em>kedua, </em>melalui mekanisme ASEAN, dan k<em>etiga</em>, melalui mekanisme Mahkamah Internasional dengan mengedepankan <em>equitable principle </em>dan <em>relevant circumstances.</em></p><p><strong>Kata kunci : </strong>Pulau-pulau terluar, pengelolaan batas wilayah, penyelesaian sengketa maritim, negara kepulauan</p>
Actitudes frente a la autoexploración de mama en dos facultades de ciencias de la salud de Ica, Perú: un estudio piloto
Authors: Torres-Roman J. Smith , Arce-Huamani Miguel Ángel , Ruiz Eloy F , Mejía Christian R 
Published: May 2017

Señor editor: El cáncer de mama es la neoplasia más frecuente entre las mujeres, con un estimado de 1.67 millones de nuevos casos diagnosticados en 2012 (25% de todos loscánceres). Entre 1990 y 2013, las tasas de incidencia estandarizada por edad por cada 100 000 mujeres han incrementado en 17% a nivel mundial, siendo más afectados los países en desarrollo, donde cerca de la mitad de los casos corresponden a una enfermedad avanzada debido al diagnóstico tardío y al pobre acceso al tratamiento. En Perú, el cáncer de mama ocupa la segunda causa de muerte por cáncer en mujeres, detrás del cervicouterino, y su supervivencia se estima en alrededor de 60 a 70% a los cinco años del diagnóstico...
Bee diversity (Hymenoptera, Apoidea) in Araucaria forest in southern Brazil
Authors: Dubet da Silva Mouga Denise Monique , Nogueira-Neto Paulo , Warkentin Manuel , Feretti Vanessa , Dec Enderlei 
Published: May 2017

The apifauna of an araucaria forest in southern Brazil was studied during 2001 – 2003, using entomological nets on flowering plants. A total of 2,749 individuals were sampled from five subfamilies and 93 species of bees. A total of 82 species with up to 10 individuals were sampled and 29 species had no distribution for Santa Catarina. Non-corbiculate Apidae and Halictidae species predominated as well as individuals of corbiculate Apidae and Halictidae. There was a decrease in species richness in cold seasons, being then sampled only Augochloropsis sp. 01, Augochloropsis sp. 10, Exomalopsis tomentosa, Neocorynura aenigma, Paroxystoglossa brachycera, Trigona spinipes and Apis mellifera. A bivoltine pattern was noticed, with a peak in May and in September-November, for richness and abundance. Ecological indexes over the months were different with and without A. mellifera. The bee accumulation curve remained in elevation until the end of sampling. The richness estimators indicated values of 142 and 175 species. The bee species were sampled on 125 species of plants of 40 famillies and the most visited were Asteraceae, Fabaceae/Solanaceae, Euphorbiaceae/Lamiaceae, Malvaceae/Rosaceae and Commelinaceae/Cucurbitaceae/ Liliaceae/Verbenaceae. A total of 48 species of plants characteristics of araucaria forests were sampled.
Viva a chuva: um estudo dos mecanismos publicitários de persuasão
Authors: Melim Mauricio José , Calado Alana Da Silva , Calado Aline Mara 
Published: May 2017

Persuasão é um tema central na publicidade, no meio profissional e no meio acadêmico. O presente artigo analisa um anúncio do Shopping Mueller de Joinville, situado nessa que é a maior cidade de Santa Catarina. A análise busca identificar e descrever os mecanismos de convencimento inscritos no anúncio. Isso é feito a partir de um quadro teórico que conjuga conceitos de psicologia social e de semiótica. Em um primeiro momento, busca-se identificar os componentes psicossociais da estratégia persuasiva do anúncio. Para em seguida descrever semioticamente esses componentes, isto é, descrever como foram materializados no anúncio, através de quais signos (figurativos, linguísticos ou plásticos). O Shopping Mueller é uma referência para Joinville e também para a região norte do estado. Revelar suas estratégias persuasivas é uma maneira de indicar e explicar as razões de seu sucesso.
Salivary leptin levels in normal weight and overweight individuals and their correlation with orthodontic tooth movement
Authors: Jayachandran Tamizhmani , Srinivasan Bhadrinath , Padmanabhan Sridevi 
Published: May 2017

ABSTRACTObjectives:To assess and compare the concentration of leptin in saliva between normal weight and overweight individuals and to evaluate the rate of orthodontic tooth movement.Materials and Methods:Thirty female subjects were divided into two groups: I (normal weight) and II (overweight group) based on their body mass index. All subjects underwent fixed appliance therapy requiring upper first premolar extraction and distal movement of the canine. Distal force was applied to the maxillary right canine using active lacebacks. Salivary samples were collected just before force application (T0), 1 hour (T1), and 1 month (T2) after force application. The rate of tooth movement was evaluated over 3 months and was measured on study models.Results:At all three time intervals, mean leptin concentration was greater in overweight individuals than normal weight individuals. In both groups at T1, the mean leptin concentration was found to increase significantly compared with the baseline value (T0), but at T2, the leptin concentration declined to values lesser than the baseline values (T0).Conclusions:Overweight individuals had greater salivary leptin concentration. There was a positive correlation between salivary leptin concentration and rate of tooth movement in both normal and overweight individuals. The rate of tooth movement is decreased in overweight individuals as compared with normal weight individuals.