bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic bevacizumab for recurrent respiratory papillomatosis: A national survey
Authors: Best Simon R. , Mohr Michael , Zur Karen B. 
Published: June 2017

Objectives/HypothesisAggressive laryngeal, tracheal, and pulmonary papilloma is an extremely challenging clinical problem without proven treatment options. A recent German report documented promising results with systemic bevacizumab. The objective of this study is to report the initial experience of this novel treatment in the United States for recurrent respiratory papillomatosis (RRP).Study DesignCases series.MethodsElectronic survey of the RRP Task Force of the American Society of Pediatric Otolaryngology, American Broncho‐Esophagological Association, and physicians known to the authors to have used systemic bevacizumab for RRP.ResultsEleven completed surveys were obtained. In three cases, systemic bevacizumab was considered clinically but not administered. Eight patients were treated with systemic bevacizumab, all for aggressive papillomatosis uncontrolled by surgical and adjuvant therapy, including seven of eight with pulmonary disease. Treatment dosing ranged from 5 to 10 mg/kg every 2 to 4 weeks, with all patients responding (7/8 partial response, 1/8 complete response). In four patients who had postbevacizumab chest imaging, three demonstrated improvement of disease and one stabilization. Treatment interval could be lengthened in seven patients and clinical response maintained. One patient with long‐standing pulmonary disease (>10 years) was diagnosed with malignant transformation while on treatment, and bevacizumab was discontinued in lieu of other chemotherapeutic agents. All other patients continue on systemic bevacizumab with minimal complications (hemoptysis n = 1, proteinuria n = 1).ConclusionsSystemic bevacizumab appears to have significant promise in the most treatment‐resistant and aggressive forms of papillomatosis with a low complication profile. These results suggest bevacizumab should be studied in a formal clinical trial for RRP.Level of Evidence4. Laryngoscope, 127:2225–2229, 2017
Evaluation of high‐fidelity simulation as a training tool in transoral robotic surgery
Authors: Bur Andrés M. , Gomez Ernest D. , Newman Jason G. , Weinstein Gregory S. , O'Malley Bert W. , Rassekh Christopher H. , Kuchenbecker Katherine J. 
Published: June 2017

Objectives/HypothesisTo develop and evaluate a high‐fidelity training simulator for transoral robotic posterior hemiglossectomy.Study DesignProspective observational study.MethodsWe constructed a transoral robotic surgery (TORS) simulator using porcine tongue in a modified airway mannequin. Twenty‐nine surgeons performed transoral robotic posterior hemiglossectomy on the simulator. The 20 resident subjects completed six trials each, and the five fellows and four attending surgeons completed two trials each. In addition to instrument vibrations, surgical video was recorded for each trial and was blindly rated using the Global Evaluative Assessment of Robotic Skill (GEARS), a validated instrument for assessing robotic surgical skill.ResultsAttending surgeons were faster (P = .004) and demonstrated greater technical skill than fellows or residents (P < .001). Resident completion time generally decreased over the study, becoming significantly faster by the fifth trial (P = .02). A similar trend was seen in resident GEARS scores, which generally increased and were significantly improved by the fourth trial (P = .008). Instrument vibrations were not significantly different between subject groups. Finally, subjects highly rated the realism and training value of the TORS simulator (mean 4.4 and 4.7 out of 5, respectively).ConclusionsThe reported findings support using the described simulator as a training tool for TORS. Residents significantly improved in speed and technical skill over the course of six trials but did not achieve the performance levels of attending surgeons. These results demonstrate that high‐fidelity simulation is a valuable tool for training novice surgeons in transoral robotic surgery.Level of EvidenceNA. Laryngoscope, 127:2790–2795, 2017
Chitosan/polyvinyl alcohol/amino functionalized multiwalled carbon nanotube pervaporation membranes: Synthesis, characterization, and performance
Authors: Langari Sepideh , Saljoughi Ehsan , Mousavi Seyed Mahmoud 
Published: June 2017

In the present study, novel biodegradable nanocomposite membranes were prepared by adding the amino functionalized multiwalled carbon nanotube (NH2‐MWCNT) to the chitosan/polyvinyl alcohol blend polymers, and the obtained membranes were used for dehydration of isopropyl alcohol through pervaporation process. For this purpose, the membranes were prepared with chitosan/polyvinyl alcohol ratio of 4:1 on the basis of “solution casting” method and then crosslinked using glutaraldehyde, after addition of different amounts of NH2‐MWCNT. The prepared membranes were characterized using scanning electron microscopy, contact angle, mechanical strength, degree of swelling (DS), and biodegradability. Also, the ability of the prepared membranes in dehydration of isopropyl alcohol was determined using pervaporation experiments. Results indicated that contact angle, mechanical resistance, separation factor (α), and pervaporation separation index were increased with the addition of NH2‐MWCNT up to 10 wt% (relative to the total amount of polymer) and then decreased in the higher presence of nanotubes (15 wt%). Furthermore, the DS and permeate flux were first decreased and then increased for the same mentioned amounts of additive. In this study, optimized membrane was obtained by the addition of 10 wt% NH2‐MWCNT. This membrane showed the maximum α (99.5), pervaporation separation index parameter (78.29 kg m−2 h−1), biodegradability, and mechanical stability as well as minimum DS.
Room temperature processable heat‐resistant epoxy‐oxazolidone‐based syntactic foams
Authors: Robert Temina Mary , Nair Soorya , Mathew Dona , Reghunadhan Nair C.P. 
Published: June 2017

Syntactic foams based on oxazolidone‐modified epoxy resin using glass microballoons as reinforcing filler with varying densities were processed. The influence of various grades of microballoons and their concentration on the mechanical, thermal, thermomechanical, and flammability characteristics were investigated. The effect of temperature on the compressive strength with density was monitored in detail. By incorporating the microballoons, Tg of the syntactic foam increased from 90 °C to 115 °C. Thermal conductivity was found to decrease from (0.064 to 0.056 W/(m·K)) in conjunction with decreasing resin to filler ratio. In the case of composites filled with K25 alone, the creation of large voids due to less effective packing between the microballoons led to lower thermal conductivity. The specific heat of the different composites was in the range of 0.32 to 0.44 cal/g/°C, and the coefficient of thermal expansion was in the range of 13.2 to 17.4 × 10−6/°C with limiting oxygen index of 28% to 33%.
Enhanced β‐phase in PVDF polymer nanocomposite and its application for nanogenerator
Authors: Singh Huidrom Hemojit , Singh Simrjit , Khare Neeraj 
Published: June 2017

Harvesting energy from the ambient mechanical energy by using flexible piezoelectric nanogenerator is a revolutionary step toward achieving reliable and green energy source. Polyvinylidene fluoride (PVDF), a flexible polymer, can be a potential candidate for the nanogenerator if its piezoelectric property can be enhanced. In the present work, we have shown that the polar crystalline β‐phase of PVDF, which is responsible for the piezoelectric property, can be enhanced from 48.2% to 76.1% just by adding ZnO nanorods into the PVDF matrix without any mechanical or electrical treatment. A systematic investigation of PVDF‐ZnO nanocomposite films by using X‐ray diffractometer, Fourier transform infrared spectroscopy, and polarization‐electric field loop measurements supports the enhancement of β‐phase in the flexible nanocomposite polymer films. The piezoelectric constant (d33) of the PVDF‐ZnO (15 wt%) film is found to be maximum of approximately −1.17 pC/N. Nanogenerators have been fabricated by using these nanocomposite films, and the piezoresponse of PVDF is found to enhance after ZnO loading. A maximum open‐circuit voltage ~1.81 V and short‐circuit current of 0.57 μA are obtained for 15 wt% ZnO‐loaded PVDF nanocomposite film. The maximum instantaneous output power density is obtained as 0.21 μW/cm2 with the load resistance of 7 MΩ, which makes it feasible for the use of energy harvesting that can be integrated to use for driving small‐scale electronic devices. This enhanced piezoresponse of the PVDF‐ZnO nanocomposite film‐based nanogenerators attributed to the enhancement of electroactive β‐phase and enhanced d33 value in PVDF with the addition of ZnO nanorods.
Prenatal incision of ureterocele causing bladder outlet obstruction: a multicenter case series
Authors: Chalouhi Gihad E. , Morency Anne‐Maude , De Vlieger Roland , Martinez José Maria , Blanc Thomas , Hodges Ryan , Gueneuc Alexandra , Ryan Greg , Deprest Jan , Gratacos Eduard , Ville Yves 
Published: June 2017

AbstractWe reviewed data from a cohort of fetuses with ureterocele diagnosed and operated prenatally in four fetal therapy centers. Inclusion criteria were (1) ureterocele confirmed on detailed fetal ultrasound examination, (2) absence of additional fetal malformations, and (3) fetal intervention to decompress the ureterocele with local institutional review boards' approval. Data on sonographic follow‐up, obstetrical, neonatal outcome, and postnatal evaluation were collected. Ten cases of prenatally treated ureterocele are described. Six cases benefited from a fetoscopy for laser incision and decompression, two cases had an ultrasound guided puncture before resorting to a fetoscopy with laser incision, one case had a balloon catheterization under ultrasound guidance, and one case had an ultrasound‐guided opening of the ureterocele with a laser fiber passed through a 20‐gauge needle. Mean gestational age at diagnosis was 21.6 GW. Two cases underwent termination of pregnancy. The remaining eight cases recovered normal amniotic fluid volume and delivered a liveborn child at a mean gestational age of 38.6 GW with normal creatinine levels during the first week of life. Prenatal incision provided complete treatment of severely obstructive ureteroceles in 80% of the cases and allowed improvement of urinary electrolytes, renal size and echogenicity, bladder filling in all survivors, and recollection of normal amniotic fluid volume, in case of oligoanhydramnios. © 2017 John Wiley & Sons, Ltd.
CodeMapper: semiautomatic coding of case definitions. A contribution from the ADVANCE project
Authors: Becker Benedikt F.H. , Avillach Paul , Romio Silvana , van Mulligen Erik M. , Weibel Daniel , Sturkenboom Miriam C.J.M. , Kors Jan A. ,   for the ADVANCE consortium
Published: June 2017

AbstractBackgroundAssessment of drug and vaccine effects by combining information from different healthcare databases in the European Union requires extensive efforts in the harmonization of codes as different vocabularies are being used across countries. In this paper, we present a web application called CodeMapper, which assists in the mapping of case definitions to codes from different vocabularies, while keeping a transparent record of the complete mapping process.MethodsCodeMapper builds upon coding vocabularies contained in the Metathesaurus of the Unified Medical Language System. The mapping approach consists of three phases. First, medical concepts are automatically identified in a free‐text case definition. Second, the user revises the set of medical concepts by adding or removing concepts, or expanding them to related concepts that are more general or more specific. Finally, the selected concepts are projected to codes from the targeted coding vocabularies. We evaluated the application by comparing codes that were automatically generated from case definitions by applying CodeMapper's concept identification and successive concept expansion, with reference codes that were manually created in a previous epidemiological study.ResultsAutomated concept identification alone had a sensitivity of 0.246 and positive predictive value (PPV) of 0.420 for reproducing the reference codes. Three successive steps of concept expansion increased sensitivity to 0.953 and PPV to 0.616.ConclusionsAutomatic concept identification in the case definition alone was insufficient to reproduce the reference codes, but CodeMapper's operations for concept expansion provide an effective, efficient, and transparent way for reproducing the reference codes.
Confirmatory factor analyses comparing parental involvement frameworks with secondary students
Authors: Duppong Hurley Kristin , Lambert Matthew C. , January Stacy‐Ann A. , Huscroft D'Angelo Jacqueline 
Published: June 2017

AbstractGiven the lack of research on measurement models used to operationalize parental involvement with secondary students, the goal of this research is to examine the measurement properties of the three‐domain conceptualization of parental involvement including school‐based involvement, home‐based involvement, and academic socialization, compared to a more nuanced six domain conceptualization school‐based (1) school/parent communication, (2) attending school activities, home‐based (3) home activities, (4) homework help, academic socialization, (5) parent–child communication about education, and (6) parental aspirations for child's education. When comparing the fit among the models, the six‐factor model had best fit indices and indicated varied correlations among the subdomains. The six‐factor model allowed for more nuanced variations among the subdomains that may be helpful when assessing parental involvement with high school students.
Unambiguous regiochemical assignment of sulfoquinovosyl mono‐ and diacylglycerols in parsley and spinach leaves by liquid chromatography/electrospray ionization sequential mass spectrometry assisted by regioselective enzymatic hydrolysis
Authors: Granafei Sara , Losito Ilario , Palmisano Francesco , Cataldi Tommaso R.I. 
Published: June 2017

RationaleSulfoquinovosylmonoglycerides (SQMG) and sulfoquinovosyldiglycerides (SQDG) in the lipid extracts of parsley (Petroselinum crispum) and spinach (Spinacia oleracea) leaves were investigated. The aim of this work was to assess and establish the chemical characterization of fatty acyl chains in sulfolipids (SQMG and SQDG) and their regiochemistry.MethodsA key component of this approach is a combination of hydrolysis reactions catalyzed by Lecitase® Ultra, which is a sn1‐regioselective hydrolase enzyme, and reversed‐phase liquid chromatography with electrospray ionization and sequential mass spectrometry (RPLC/ESI‐MS) by collision‐induced dissociation (CID)‐MSn (n = 2, 3).ResultsThe occurrence of SQMG bearing 16:0 or 18:3 acyl chains was established for the first time. A regiochemistry‐dependent fragmentation pattern of SQMG was attained whereby the sulfoquinovosyl anion ([C6H11O8S]− at m/z 243.0) provides a diagnostic product ion. Regioselective enzymatic treatment also provided a posteriori confirmation of a widely accepted fragmentation rule for SQDG. The sulfoquinovosyl anion was found to play a role also in the fragmentation pattern of SQDG, whose regiochemical assignment could be ultimately confirmed by MS3 experiments.ConclusionsThe predominant sulfolipid in leaf extracts of raw parsley (Petroselinum crispum) and spinach (Spinacia oleracea) was identified as SQDG 18:3/16:0, along with SQMG 18:3/0:0 and SQMG 16:0/0:0. The present CID‐MS‐based method can be considered a successful approach to validate the regiochemical characterization of sulfolipids paving the way for their unambiguous characterization.
Output‐feedback model predictive control for stochastic systems with multiplicative and additive uncertainty
Authors: Li Jiwei , Li Dewei , Xi Yugeng , Xu Yuli , Gan Zhongxue 
Published: June 2017

SummaryThis paper studies the output‐feedback model predictive control (MPC) design problem for linear systems with multiplicative and additive random uncertainty. We first present an off‐line optimization algorithm to optimize feedback gains of the observer and the dual‐mode control policy. After that, by defining a cuboid tube whose center and boundary are both time‐varying variables, we develop a set sequence with increased freedom to contain stochastic system trajectories. A quadratic performance function with analytic upper and lower bounds is minimized such that it decreases exponentially to a finite range under the expectation. The resulting MPC algorithms are proved to guarantee practically stochastic input‐to‐state stability. A numerical example of the wind turbine model illustrates the properties of the MPC algorithms.
Stabilization of stochastic coupled systems with Markovian switching via feedback control based on discrete‐time state observations
Authors: Wu Yongbao , Yan Shihan , Fan Meng , Li Wenxue 
Published: June 2017

SummaryThis study investigates the stabilization issue of stochastic coupled systems with Markovian switching via feedback control. A state feedback controller based on the discrete‐time observations is applied for the stabilization purpose. By making use of the graph theory and the Lyapunov method, we establish both Lyapunov‐ and coefficient‐type sufficient criteria to guarantee the stabilization in the sense of
stability, and then, we further develop the mean‐square asymptotical stability. In particular, the upper bound of the duration between 2 consecutive state observations is well formulated. Applications to a concrete stabilization problem of stochastic coupled oscillators with Markovian switching and some numerical analyses are presented to illustrate and to demonstrate the easy verifiability, effectivity, and efficiency of our theoretical findings.
Synthesis of Novel Mannich Derivatives of Bakuchiol as Apoptotic Inducer through Caspase Activation and PARP‐1 Cleavage in A549 Cells
Authors: Gupta Nidhi , Sharma Sonia , Raina Arun , Bhushan Shashi , Malik Fayaz A. , Sangwan Payare L. 
Published: June 2017

AbstractA new series of bakuchiol 1 Mannich derivatives was synthesized by reaction with various substituted secondary amines. The analogs were evaluated for cytotoxicity against a panel of three different human cancer cell lines breast (MCF‐7), colon (HCT‐116) and lung (A549). Cytotoxicity screening results showed that many compounds displayed significant in vitro cytotoxic effects against different cancer cell lines. Compounds 9, 12, 14, 16, 17 and 21 showed promising cytotoxic effects compared to parent molecule 1 and among them compound 14 was found to be most potent analog with IC50 5 μM against all the cell lines examined. It was about 8‐fold more potent against MCF‐7 and A549 and 10‐fold more potent against HCT‐116 cell line in comparison to the parent molecule 1. Structure activity relationship (SAR) study of all synthesized derivatives was carried out. Further, compound 14 induced apoptosis in lung cancer cells (A549) through caspase activation followed by PARP‐1 cleavage.
Mitigation and adaptation in polycentric systems: sources of power in the pursuit of collective goals
Authors: Morrison Tiffany H. , Adger W. Neil , Brown Katrina , Lemos Maria Carmen , Huitema Dave , Hughes Terry P. 
Published: June 2017

Polycentric governance involves multiple actors at multiple scales beyond the state. The potential of polycentric governance for promoting both climate mitigation and adaptation is well established. Yet, dominant conceptualizations of polycentric governance pay scant attention to how power dynamics affect the structure and the outcomes of climate action. We review emerging evidence on power within polycentric and distributed governance across the climate, forestry, marine, coastal, urban, and water sectors, and relate them to established positions on power within research on federalism, decentralization, international relations, and networked governance. We develop a typology of design, pragmatic, and framing power that focuses on how and in whose interests power is mobilized to achieve outcomes. We propose that the conceptual model helps to explain power dynamics across different sectors and across both climate change mitigation and adaptation. Significant research challenges arising from the analysis include the measurement and monitoring of the outcomes of power asymmetries over time. WIREs Clim Change 2017, 8:e479. doi: 10.1002/wcc.479This article is categorized under:

Policy and Governance > Multilevel and Transnational Climate Change Governance
Microstructural and Phase Composition Differences Across the Interfaces in Al/Ti/Al Explosively Welded Clads
Authors: Fronczek Dagmara Malgorzata , Chulist Robert , Litynska-Dobrzynska Lidia , Lopez Gabriel Alejandro , Wierzbicka-Miernik Anna , Schell Norbert , Szulc Zygmunt , Wojewoda-Budka Joanna 
Published: June 2017

Abstract
The microstructure and phase composition of Al/Ti/Al interfaces with respect to their localization were investigated. An aluminum-flyer plate exhibited finer grains located close to the upper interface than those present within the aluminum-base plate. The same tendency, but with a higher number of twins, was observed for titanium. Good quality bonding with a wavy shape and four intermetallic phases, namely, TiAl3, TiAl, TiAl2, and Ti3Al, was only obtained at the interface closer to the explosive material. The other interface was planar with three intermetallic compounds, excluding the metastable TiAl2 phase. As a result of a 100-hour annealing at 903 K (630 °C), an Al/TiAl3/Ti/TiAl3/Al sandwich was manufactured, formed with single crystalline Al layers. A substantial difference between the intermetallic layer thicknesses was measured, with 235.3 and 167.4 µm obtained for the layers corresponding to the upper and lower interfaces, respectively. An examination by transmission electron microscopy of a thin foil taken from the interface area after a 1-hour annealing at 825 K (552 °C) showed a mixture of randomly located TiAl3 grains within the aluminum. Finally, the hardness results were correlated with the microstructural changes across the samples.