bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating public perception on use of ChatGPT in initial consultations prior to healthcare provider consultations
Authors: Hussain Salman , Alherz Mohammad , Albazee Ebraheem , Almhanedi Hamad , Hayat Jafar , Lari Mohammad , Lari Ali 
Published: October 2024

Background:
This study investigates public perception of using AI-powered ChatGPT for initial consultations before seeing healthcare providers. It aims to understand AI’s capabilities and how to implement such tools in healthcare settings.

Methods:
A survey containing nineteen questions was distributed to 391 participants aiming to explore public perceptions on the use of ChatGPT prior to initial healthcare consultations via questions pertaining to several domains regarding use of ChatGPT in healthcare. Collected data was summarized and presented through visual depictions. Continuous variables with normal distributions were expressed as median and interquartile range, while categorical variables are represented as numbers and percentages. Statistical significance was assessed using the Mann–Whitney U test for continuous variables and the chi-square test (χ²) for categorical variables.

Results:
The median satisfaction score was 3.00 (IQR: 2.00, 3.00), providing insights into user satisfaction. 42.7% believed AI-powered chatbots adequately addresses healthcare concerns. Comfort levels in sharing health information and confidence (accuracy, reliability) had median scores of 3.00 (IQR: 2.00, 4.00) and 3.00 (IQR: 2.00, 3.00), respectively, on a scale of 1 to 5. 31.2% were willing to try AI in their next consultation, 40.4% were unsure, and 28.4% declined. Notably, 64.5% preferred interacting with a human healthcare provider, and 46.0% expressed that their comfort with AI use depended on the specific healthcare concern.

Conclusion:
The current findings shed light on the importance of understanding the capabilities of ChatGPT. Further research needs to be carried out to better understand how ChatGPT can be implemented in the current era.
Stem Cells Treatment for Subarachnoid Hemorrhage
Authors: Wang Wei , Wang Ying , Gao Liansheng 
Published: October 2024

Background:
Subarachnoid hemorrhage (SAH) refers to bleeding in the subarachnoid space, which is a serious neurologic emergency. However, the treatment effects of SAH are limited. In recent years, stem cell (SC) therapy has gradually become a very promising therapeutic method and advanced scientific research area for SAH.

Review Summary:
The SCs used for SAH treatment are mainly bone marrow mesenchymal stem cells (BMSCs), umbilical cord mesenchymal stem cells (hUC-MSCs), dental pulp stem cells (DPSCs), neural stem cells (NSCs)/neural progenitor cell (NPC), and endothelial progenitor cell (EPC). The mechanisms mainly included differentiation and migration of SCs for tissue repair; alleviating neuronal apoptosis; anti-inflammatory effects; and blood–brain barrier (BBB) protection. The dosage of SCs was generally 106 orders of magnitude. The administration methods included intravenous injection, nasal, occipital foramen magnum, and intraventricular administration. The administration time is generally 1 hour after SAH modeling, but it may be as late as 24 hours or 6 days. Existing studies have confirmed the neuroprotective effect of SCs in the treatment of SAH.

Conclusions:
SC has great potential application value in SAH treatment, a few case reports have provided support for this. However, the relevant research is still insufficient and there is still a lack of clinical research on the SC treatment for SAH to further evaluate the effectiveness and safety before it can go from experiment to clinical application.
Atomistic Insights into gp82 Binding: A Microsecond, Million-Atom Exploration of Trypanosoma cruzi Host-Cell Invasion
Authors: Rosa Raissa S. L. , Leal da Silva Manuela , Bernardi Rafael C. 
Published: October 2024

AbstractChagas disease, caused by the protozoanTrypanosoma cruzi, affects millions globally, leading to severe cardiac and gastrointestinal complications in its chronic phase. The invasion of host cells byT. cruziis mediated by the interaction between the parasite’s glycoprotein gp82 and the human receptor lysosome-associated membrane protein 2 (LAMP2). While experimental studies have identified a few residues involved in this interaction, a comprehensive molecular-level understanding has been lacking. In this study, we present a 1.44-million-atom computational model of the gp82 complex, including over 3,300 lipids, glycosylation sites, and full molecular representations of gp82 and LAMP2, making it the most complete model of a parasite-host interaction to date. Using microsecond-long molecular dynamics simulations and dynamic network analysis, we identified critical residue interactions, including novel regions of contact that were previously uncharacterized. Our findings also highlight the significance of the transmembrane domain of LAMP2 in stabilizing the complex. These insights extend beyond traditional hydrogen bond interactions, revealing a complex network of cooperative motions that facilitateT. cruziinvasion. This study not only confirms key experimental observations but also uncovers new molecular targets for therapeutic intervention, offering a potential pathway to disruptT. cruziinfection and combat Chagas disease.
Trafficking of the Telomerase RNA using a Novel Genetic Approach
Authors: Day Jessica K. , Palmero Brett J. , Allred Amanda L. , Li Junya , Hooda Fatima B. , Witte Graeme , Dejneka Alexandra M. , Sandler Anna M. , Kirk Karen E. 
Published: October 2024

AbstractTelomeres are specialized nucleoprotein structures situated at eukaryotic chromosome ends, vital for preserving genetic information during cell replication. Telomerase, a holoenzyme composed of telomerase reverse transcriptase and an RNA template component (TER), is responsible for elongating telomeric DNA. The intracellular trafficking of the telomerase RNA varies, either staying in the nucleus or exiting to the cytoplasm, depending on the organism. For example, inSaccharomyces cerevisiae, the RNA template is exported to the cytoplasm, whereas in mammalian cells and protozoa, it remains within the nucleus.Aspergillus nidulans, a filamentous fungus, offers an outstanding model for investigating telomeres and telomerase due to its characterized telomerase components, exceptionally short and tightly regulated telomeres, and innovative heterokaryon rescue technique. To determine the pathway of telomerase RNA trafficking inA. nidulans, we leveraged its unique capabilities to exist in both uni- and multi-nucleate states within a heterokaryon. This involved creating a TER knockoutA. nidulansstrain (TERΔ) and examining the resulting colonies for signs of heterokaryon formation. Heterokaryons would imply the export of TER from one nucleus and its import into aTERΔnucleus. Interestingly, theTERΔstrain consistently failed to produce heterokaryons, instead giving rise to diploid colonies. This surprising finding strongly implies that telomerase assembly predominantly takes place within the nucleus ofA. nidulans, distinguishing it from the biogenesis and trafficking pattern observed in yeast.
Partially characterized topology guides reliable anchor-free scRNA-integration
Authors: He Chuan , Filippidis Paraskevas , Kleinstein Steven , Guan Leying 
Published: October 2024

AbstractSingle-cell RNA sequencing (scRNA-seq) is an important technique for obtaining biological insights at cellular resolution, with scRNA-seq batch integration a key step before downstream statistical analysis. Despite the plethora of methods proposed, achieving reliable batch correction while preserving the heterogeneity of biological signals that define cell type continues to pose a challenge, with existing methods’ performance varying significantly across different scenarios and datasets. To address this, we propose scCRAFT, an autoencoder model designed to segregate cell-type-related biological signals from batch effects for reliable multi-batch scRNA-seq integration. scCRAFT comprises three key loss components: a reconstruction loss that targets observation reconstruction, a multi-domain adaptation loss aimed at eliminating batch effects, and an innovative dual-resolution triplet loss for preserving topology within each batch, which is introduced as an effective mechanism to counteract the over-correction effect of domain adaptation loss amid heterogeneous cell distributions across batches. We show that scCRAFT effectively manages unbalanced batches, rare cell types, and batch-specific cell phenotypes in simulations, and surpasses state-of-the-art methods in a diverse set of real datasets.
Mitochondrial-targeted plastoquinone therapy ameliorates early onset muscle weakness that precedes ovarian cancer cachexia in mice
Authors: Delfinis Luca J. , Khajehzadehshoushtar Shahrzad , Flewwelling Luke D. , Andrews Nathaniel J. , Garibotti Madison C. , Gandhi Shivam , Brahmbhatt Aditya N. , Morris Brooke A. , Garlisi Bianca , Lauks Sylvia , Aitken Caroline , Tsitkanou Stavroula , Simpson Jeremy A. , Greene Nicholas P. , Cheng Arthur J. , Petrik Jim , Perry Christopher G.R. 
Published: October 2024

AbstractCancer cachexia, and the related loss of muscle and strength, worsens quality of life and lowers overall survival. Recently, a novel ‘pre-atrophy’ muscle weakness was identified during early-stage cancer. While mitochondrial stress responses are associated with early-stage pre-atrophy weakness, a causal relationship has not been established. Using a robust mouse model of metastatic epithelial ovarian cancer (EOC)-induced cachexia, we found the well-established mitochondrial-targeted plastoquinone SkQ1 partially prevents pre-atrophy weakness in the diaphragm. Furthermore, SkQ1 improved force production during atrophy without preventing atrophy itself in the tibialis anterior and diaphragm. EOC reduced flexor digitorum brevis (FDB) force production and myoplasmic free calcium ([Ca2+]i) during contraction in single muscle fibers, both of which were prevented by SkQ1. Remarkably, changes in mitochondrial reactive oxygen species and pyruvate metabolism were heterogeneous across time and between muscle types which highlights a considerable complexity in the relationships between mitochondria and muscle remodeling throughout EOC. These discoveries identify that muscle weakness can occur independent of atrophy throughout EOC in a manner that is linked to improved calcium handling. The findings also demonstrate that mitochondrial-targeted therapies exert a robust effect in preserving muscle force during the early pre-atrophy period and in late-stage EOC once cachexia has become severe.
Unveiling the missing innovation – an actor–network theory analysis of regulatory efforts towards universal design
Authors: Grangaard Sidse , Lygum Victoria Linn 
Published: October 2024

PurposeThe purpose of this paper is to study and analyse challenges in a regulatory innovation process in the field of accessibility and universal design (UD) practice. The study takes its starting point in a Danish regulatory initiative concerning innovation in building regulations. The aim of the initiative was to facilitate a new approach, which acknowledges human diversity to a greater degree than is the case with the traditional accessibility approach that relies on prescriptive requirements.Design/methodology/approachThe actor–network theory perspective of translation is employed to analyse the process and the complexity of the network of elements involved in the efforts to develop a new approach. The analysis is grounded in a qualitative survey, including semi-structured interviews, with respondents from architectural firms and respondents from local building authorities (municipalities) of their experiences with the building regulations and their way of working with accessibility or UD. The analysis concerned the following questions: 1) Which actors were intended to be enrolled in the network of an initiative about UD innovation? and 2) What factors contributed to the failure of the efforts of the building sector to develop innovative UD solutions?FindingsThe findings show that none of the actors involved succeeded with an innovation solution. Lack of knowledge about UD, accessibility, and the low status of the subject together with tight economy and the anticipation of expensive solutions, prevented the architectural firms and building surveyors from embracing innovative solutions. Based on the findings, the discussions reflect on the implications for the future adoption of UD in future policymaking.Originality/valueLooking into the complexity of an innovative initiative, this paper contributes to the field of regulation concerning universal design.
Shadows and lights: disabled workers’ use of digital technologies in the workplace
Authors: Hachana Rim 
Published: October 2024

PurposeIn this research, we apply a sociological lens to reconstruct the perspectives of disabled workers in their use of digital technologies within the organizational setting. Our study has two objectives. First, we aim to investigate how disabled workers use digital technologies to enact socially valued roles, thereby helping to counteract internalized societal norms through enhancing workplace inclusion. Second, we seek to explain under which conditions disabled workers can better approach the digital imperatives in the workplace.Design/methodology/approachThis research has a qualitative research design, employing the thematic-content analysis method. We conducted one-to-one interviews with 33 disabled workers in various positions who used a variety of digital technologies in their work.FindingsOur findings outline how the digital environment in the workplace creates a distinct set of rules and expectations that disabled workers must navigate. These rules reflect the structures and practices inherent in digital technologies (logic of practice), which either empower or constrain disabled workers based on their habitus and the ability to leverage various forms of capital. This study discusses how some disabled workers who have greater access to cultural capital (such as digital skills) are better positioned to navigate the digital environment, whereas those with limited access to such capital face additional challenges. It explained how symbolic violence arises in the experiences of some disabled workers by revealing how the implicit rules of the digital workplace reinforce power dynamics that marginalize them, thereby perpetuating social domination.Originality/valueIn examining the ambivalent role of digital technologies for disabled workers, this research navigates the complex interplay between empowerment and barriers within the digital workplace. Drawing on Bourdieu’s theory of practice, this study explains how the enactment of digital technologies can enhance the sociability and inclusion of disabled workers. Thanks to his concepts of habitus, forms of capital, field, illusion and symbolic violence, we highlight the disruptions that can emerge in reconciling disability with digital requirements. Moreover, the study makes pivotal contributions to the discourse on diversity, inclusion and equality. It underscores the empowerment aspect, wherein digital technologies serve as critical enablers for communication, productivity and independence for disabled workers and critically evaluates the persistent barriers to digital inclusivity.
Education and women in high-skill occupations in India
Authors: Ankita  , Singh Indervir 
Published: October 2024

Purpose
This paper aims to examine women’s likelihood of being employed in a high-skill occupation compared to men in India. It also analyses the impact of education on women’s likelihood of entering a high-skill occupation.

Design/methodology/approach
This study uses data from Periodic Labour Force Survey 2018–19. National Classification of Occupations 2004 is used to classify the occupations in three categories, i.e. high-skill, medium-skill and low-skill. The paper uses ordered probit with Heckman’s sample selection method to estimate the impact of gender identity and education on women’s likelihood of entering high-skill occupations.

Findings
The results show that female workers are more likely to be employed in high-skill occupations than male workers. Formal years of schooling and technical education further improve women’s probability of working in high-skill occupations compared to men. However, an increase in monthly per capita expenditure of the households improves men’s chances of being employed in high-skill occupations in comparison to women. It suggests that gender norms are still relevant.

Originality/value
Studies have found occupational segregation in India with a large share of women being employed in low-wage work. This study examines the issue by focusing on the skill level of occupations. It found that women have a higher likelihood of entering high-skill occupations in India and education is playing an important role in it.
A swarm model with constraint coordination mechanism for unmanned aerial vehicle swarm formation maintenance in dense environments
Authors: Xiong Hui , Shi Xiuzhi , Liu JinZhen , Chen Yimei , Wang Jiaxing 
Published: October 2024

Purpose
The formation of unmanned aerial vehicle (UAV) swarm plays a critical role in numerous applications, such as unmanned agriculture, environmental monitoring and cooperative fencing. Meanwhile, the self-organized swarm model exhibits excellent performance in amorphous formation flight, and its collective motion pattern displays great potential in dense obstacle avoidance. The paper aims to realize the formation maintenance of UAVs while combining the advantage of the self-organized swarm model in avoiding dense obstacles. Thereby enhancing the flexibility, adaptability and safety of UAV swarms in dense and unpredictable scenarios.

Design/methodology/approach
In this paper, a self-organized formation (SOF) swarm model with a constrained coordination mechanism is proposed. A global information-based formation rule is designed to flexibly maintain the formation. A constraint coordination mechanism is designed to resolve the problem of constraint conflicts between formation rules and self-organized behavior rules. The model introduces a new obstacle avoidance rule to prevent deadlocks. Extensive experiments including simulations, real flights and comparative experiments are conducted to evaluate the performance of the model.

Findings
The simulation results show that SOF swarm enables the formation elastically to dense obstacles. Compared to the Vasarhelyi model, swarm performance metrics are improved. For example, the task completion time of SOF swarm is reduced by 16%, 28% and 39% across the three obstacle densities, and the order of SOF swarm is improved by 4%, 13% and 18%, respectively. The proposed model is also validated with a swarm of seven quadcopters that can successfully navigate and maintain formation in a real-world indoor environment with dense obstacles. Video at: https://youtu.be/V8hYgOHxWls.

Research limitations/implications
The proposed formation rule is based on global information construction, which presents challenges in terms of communication overhead in distributed systems.

Originality/value
An SOF swarm model is proposed, which achieves formation maintenance by incorporating formation rule and constraint coordination mechanism and improves obstacle avoidance performance by introducing a new obstacle avoidance rule. After real UAVs verification, the model is feasible for practical deployment and provides a new solution to the formation flight and formation maintenance problems encountered in dense environments.
Strategic configurations and strategic management accounting: a longitudinal case study in the credit mediation industry
Authors: Dello Sbarba Andrea 
Published: October 2024

Purpose
The purpose of this paper is to investigate the relationship between strategy, strategic management accounting (SMA) and performance. Specifically, it aims to explore how SMA alignment is achieved to support both the internal and external fit of organizational configurations and achieve superior performance.

Design/methodology/approach
This study has adopted a longitudinal case study approach, focusing on a leading company in the credit mediation industry, and uses the configurational theory and a network approach to understand how an alignment between organizational configurations and SMA leads to superior performance.

Findings
This study shows that the configurational fit involves interactions between environmental, strategic and structural elements and SMA. Moreover, it helps understanding the causal complexity of these interactions by showing how various organizational configurations, along with SMA, may lead to superior performance. Finally, from a longitudinal perspective, the study shows how SMA alignment continuously supports both the external and internal configuration fit.

Research limitations/implications
Case studies often lack generalizability due to their detailed, context-specific nature. In addition, the study assumes that aligning SMA practices with organizational configurations leads to higher performance, although outcomes may be affected by other unobserved factors.

Practical implications
This study also has practical implications for managers, as it provides a profound understanding of the role of SMA in supporting both the external and internal alignment of the organizational configuration. Managers should particularly leverage SMA to gather and analyze external environmental data, thereby enabling the organization to ensure the continuous consistency of its strategic priorities, as well as to support and reinforce both existing and emerging strategic imperatives. However, it is essential for managers to perceive SMA not as an isolated instrument, but as an integral component of the broader organizational system. Effective implementation necessitates the integration of SMA techniques with the strategic and structural elements of the organization, which complement their implementation, determining the actual contribution to external and internal fit.

Originality/value
To the best of the author’s knowledge, this study has been one of the first to adopt a qualitative approach to investigate the relationships between strategy, SMA and performance through the lens of the configurational theory. It elucidates the causal mechanisms underlying the relationships between configurations and SMA from a dynamic, change-oriented perspective, showing how SMA continuously contributes to configurational fit and performance.