bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies for and Outcome of Repeat Revascularization Surgery for Moyamoya Disease: An American Institutional Series
Authors: Teo Mario , Johnson Jeremiah , Steinberg Gary K 
Published: May 2017

Abstract

BACKGROUND
Revascularization for moyamoya disease (MMD) effectively prevents future ischemic events. However, small subsets of patients with persistent or new symptoms due to inadequate collateralization require repeat revascularizations.

OBJECTIVE
To investigate the clinical and radiological outcome of repeat revascularization in MMD patients with previous indirect or direct bypasses.

METHODS
Single institution, retrospective analysis of a prospective MMD database.

RESULTS
From 1991 to 2014, this institution performed 1244 revascularization bypasses (1107 direct, 137 indirect) in 765 patients, of whom 57 were repeat revascularizations (38 indirect, 19 direct bypass). When initially performed at the institution, the repeat revascularization rate was 4% for indirect and 1% for direct bypasses (P = .03). Cohorts with previous indirect vs direct bypass were slightly younger (mean age 23 vs 30 yr), with fewer females (61% vs 84%, P = .08), and a similar mean duration between initial bypass and repeat revascularization (49 vs 47 mo). Both groups had similar repeat revascularization due to transient ischemic attacks (66% vs 63%). One acute graft occlusion in the previous direct bypass group was revised within 1 wk postoperatively. Over 50% of the repeat revascularizations in both groups were direct bypasses; the major difference being that the repeat bypass in the direct group was to augment another vascular territory. At nearly 5 yr mean follow-up, over 80% of patients in both groups are well, free from stroke/transient ischemic attack symptoms, with excellent radiological results.

CONCLUSION
Repeat revascularization can safely and effectively prevent future ischemic events. Indirect bypass has a higher rate of repeat revascularization than direct bypass.
Can Hepatitis C Virus Antigen Testing Replace Ribonucleic Acid Polymearse Chain Reaction Analysis for Detecting Hepatitis C Virus? A Systematic Review
Authors: Khan Harun , Hill Andrew , Main Janice , Brown Ashley , Cooke Graham 
Published: May 2017

Abstract
The complexity and cost of current diagnostics for hepatitis C virus (HCV) may act as a prevention to the scale-up of treatment in the developing world. Currently, ribonucleic acid (RNA)-polymerase chain reaction tests are the gold standard. However, there is potential for the use of simpler and cheaper antigen tests to confirm HCV infection in different clinical settings. We evaluated the sensitivity and specificity of antigen assays. This was compared with the reference-standard RNA assays. A subanalysis also assessed Architect core antigen test, which is the only commercially available antigen test on the market. In 24 datasets, evaluating HCV-antigen assays in 8136 samples, the percentage of HCV-antigen positive, HCV-RNA negative was 0.57%. The percentage HCV-antigen negative, HCV-RNA positive was 3.52%. There is strong evidence that antigen detection performs as well as RNA-based assays for HCV management. The use of antigen tests could improve access to HCV care in underresourced healthcare settings.
Vascularized Fibula-Based Physis Transfer: A Follow-Up Study of Longitudinal Bone Growth and Complications
Authors: Shammas Ronnie L. , Avashia Yash J. , Farjat Alfredo E. , Catanzano Anthony A. , Levin L. Scott , Eward William C. , Brigman Brian E. , Erdmann Detlev 
Published: May 2017

Background:
The vascularized free fibula epiphyseal transfer provides an option for the preservation of limb lengthening after resection of the proximal humerus in pediatric sarcoma patients. The purpose of this study was to provide a long-term follow-up of longitudinal growth patterns and outcomes after free fibula epiphyseal transfer in upper extremity reconstruction.

Methods:
A retrospective review of 4 patients who underwent free fibula epiphyseal transfer after oncologic resection of the proximal humerus for osteosarcoma was performed. Oncologic details that could affect outcomes were included in the review: primary tumor pathology, location of malignancy, and presence of recurrence. Details on the reconstruction included longitudinal growth of the flap from the time of implantation to the most recently available radiograph and postoperative complications. The length of the fibula over time was measured from the humeral head to the olecranon process.

Results:
All patients were alive at the start of this study. The average longitudinal growth rate of the free fibula epiphyseal transfer was 0.54 ± 0.18 cm/y, and patients demonstrated satisfactory and consistent longitudinal bone growth and hypertrophy over time. All 4 patients suffered from a complication of postoperative fibula graft fracture, and 1 of 4 patients experienced unremitting peroneal nerve damage. All patients demonstrated normal wrist and hand motion with a normal arc of elbow flexion and extension.

Conclusion:
This study demonstrates that the vascularized fibula epiphyseal transfer offers the ability to preserve longitudinal limb growth and hypertrophy throughout adolescence.
A Clinical Feasibility Trial for Identification of Exceptional Responders in Whom Breast Cancer Surgery Can Be Eliminated Following Neoadjuvant Systemic Therapy
Authors: Kuerer Henry M. , Rauch Gaiane M. , Krishnamurthy Savitri , Adrada Beatriz E. , Caudle Abigail S. , DeSnyder Sarah M. , Black Dalliah M. , Santiago Lumarie , Hobbs Brian P. , Lucci Anthony , Gilcrease Michael , Hwang Rosa F. , Candelaria Rosalind P. , Chavez-MacGregor Mariana , Smith Benjamin D. , Arribas Elsa , Moseley Tanya , Teshome Mediget , Miggins Makesha V. , Valero Vicente , Hunt Kelly K. , Yang Wei T. 
Published: May 2017

Objective:
To determine the accuracy of fine-needle aspiration (FNA) and vacuum-assisted core biopsy (VACB) in assessing the presence of residual cancer in the breast after neoadjuvant systemic therapy (NST).

Summary Background Data:
Pathologic complete response (pCR) rates after NST have improved dramatically, suggesting that surgery might be avoided in some patients. Safe avoidance of surgery would require accurate confirmation of no residual invasive/in situ carcinoma.

Methods:
Forty patients with T1-3N0-3 triple-negative or HER2-positive cancer receiving NST were enrolled in this single-center prospective trial. Patients underwent ultrasound-guided or mammography-guided FNA and VACB of the initial breast tumor region before surgery. Findings were compared with findings on pathologic evaluation of surgical specimens to determine the performance of biopsy in predicting residual breast disease after NST.

Results:
Median initial clinical tumor size was 3.3 cm (range, 1.2–7.0 cm); 16 patients (40%) had biopsy-proven nodal metastases. After NST, median clinical tumor size was 1.1 cm (range, 0–4.2 cm). Nineteen patients (47.5%) had a breast pCR and were concordant with pathologic nodal status in 97.5%. Combined FNA/VACB demonstrated an accuracy of 98% (95% CI, 87%–100%), false-negative rate of 5% (95% CI, 0%–24%), and negative predictive value of 95% (95% CI, 75%–100%) in predicting residual breast cancer. VACB alone was more accurate than FNA alone (P = 0.011).

Conclusions:
After NST, image-guided FNA/VACB can accurately identify patients with a breast pCR. Based on these results, a prospective clinical trial has commenced in which breast surgery is omitted in patients with a breast pCR after NST according to image-guided biopsy.
Super-resolution microscopy reveals that disruption of ciliary transition zone architecture is a cause of Joubert syndrome
Authors: Shi Xiaoyu , Garcia Galo , Van De Weghe Julie C. , McGorty Ryan , Pazour Gregory J. , Doherty Dan , Huang Bo , Reiter Jeremy F. 
Published: May 2017

ABSTRACTDiverse human ciliopathies, including nephronophthisis (NPHP), Meckel syndrome (MKS) and Joubert syndrome (JBTS), can be caused by mutations affecting components of the transition zone, a ciliary domain near its base. The transition zone controls the protein composition of the ciliary membrane, but how it does so is unclear. To better understand the transition zone and its connection to ciliopathies, we defined the arrangement of key proteins in the transition zone using two-color stochastic optical reconstruction microscopy (STORM). This mapping revealed that NPHP and MKS complex components form nested rings comprised of nine-fold doublets. The NPHP complex component RPGRIP1L forms a smaller diameter transition zone ring within the MKS complex rings. JBTS-associated mutations inRPGRIP1Ldisrupt the architecture of the MKS and NPHP rings, revealing that vertebrate RPGRIP1L has a key role in organizing transition zone architecture. JBTS-associated mutations inTCTN2, encoding an MKS complex component, also displace proteins of the MKS and NPHP complexes from the transition zone, revealing that RPGRIP1L and TCTN2 have interdependent roles in organizing transition zone architecture. To understand how altered transition zone architecture affects developmental signaling, we examined the localization of the Hedgehog pathway component SMO in human fibroblasts derived from JBTS-affected individuals. We found that diverse ciliary proteins, including SMO, accumulate at the transition zone in wild type cells, suggesting that the transition zone is a way station for proteins entering and exiting the cilium. JBTS-associated mutations inRPGRIP1Ldisrupt SMO accumulation at the transition zone and the ciliary localization of SMO. We propose that the disruption of transition zone architecture in JBTS leads to a failure of SMO to accumulate at the transition zone, disrupting developmental signaling in JBTS.
Root interactions and plant growth in a tomato/potato onion intercropping system under different phosphorus levels
Authors: Yu Hongjie , Chen Shaocan , Zhou Xingang , Wu Fengzhi 
Published: May 2017

ABSTRACTIntercropping systems have been implemented in many parts of the world due to their beneficial effects on yield and biomass. In intercropping systems, changes in plant growth are usually related to variations in root distribution and phosphorus (P) levels, however, root distributions and root tendencies are difficult to study, as root systems grow beneath the soil surface. Therefore, we have a relatively poor understanding of the relationship between plant root interactions and plant growth in intercropping systems. In this study, a custom apparatus consisting of a transparent manual root box was used to observe intact root systems in situ. We investigated how root distribution and root tendency changed in a tomato/potato onion intercropping system under two P treatments, and how tomato plant growth was influenced. The results showed that the shoot and total biomass for the tomato plants were increased by intercropping with potato onion plants under both tested P levels, the root distribution of intercropped tomato plants was deeper than that of monocultured plants, and the tomato roots tended to grow away from the potato onion roots. Our research reveals that a deeper and more evasive root distribution is more conductive to the plant growth of the intercropped tomato.SUMMARY STATEMENTOur study can help more people clearly know the relationship between the root interactions and plant growth in mixed cultures.
Olfactory receptors are required for social behavior and neural plasticity in ants, as evidenced by CRISPR-mediated gene knockout
Authors: Yan Hua , Opachaloemphan Comzit , Mancini Giacomo , Yang Huan , Gallitto Matthew , Mlejnek Jakub , Haight Kevin , Ghaninia Majid , Huo Lucy , Leibholz Alexandra , Slone Jesse , Zhou Xiaofan , Traficante Maria , Penick Clint A. , Dolezal Kelly , Gokhale Kaustubh , Stevens Kelsey , Fetter-Pruneda Ingrid , Bonasio Roberto , Zwiebel Laurence J. , Berger Shelley , Liebig Jüergen , Reinberg Danny , Desplan Claude 
Published: May 2017

AbstractThe chemosensory system is key to establishing and maintaining social structure in eusocial insects. Ants exhibit cooperative colonial behaviors reflective of an advanced form of sociality with an extensive dependency on communication. Cuticular hydrocarbons (CHCs) serve as pheromones and cues that regulate multiple aspects of social interactions and behaviors in ants. The perception of CHCs entails odorant receptor neurons (ORNs) that express specific odorant receptors (ORs) encoded by a dramatically expandedOrgene family in ants. Until recently, studies of the biological functions of ORs in eusocial insects were stymied by the lack of genetic tools. In most eusocial insect species, only one or a few queens in a colony can transmit the genetic information to their progeny. In contrast, any worker in the antHarpegnathos saltatorcan be converted into a gamergate (pseudo-queen), and used as a foundress to engender an entire new colony and be crossed for genetic experiments. This feature facilitated CRISPR-Cas9 gene targeting to generate a germline mutation in theorcogene that encodes the obligate co-receptor whose mutation should significantly impact ant olfaction. Our results show that Orco exhibits a conserved role in the perception of general odorants but also a role in reproductive physiology and social behavior plasticity in ants. Surprisingly, and in contrast to other insect systems, the loss of OR functionality also dramatically reduces the development of the ant antennal lobe where ORNs project. Taken together, these findings open the possibility of studying the genetics of eusociality and provide inroads towards understanding the function of the expanded ORs family in eusocial insects in regulating caste determination, social communication and neuronal plasticity.
Connecting Brain Responsivity and Real-World Risk taking: Strengths and Limitations of Current Methodological Approaches
Authors: Sherman Lauren , Steinberg Laurence , Chein Jason 
Published: May 2017

AbstractIn line with the goal of limiting health risk behaviors in adolescence, a growing literature investigates whether individual differences in functional brain responses can be related to vulnerability to engage in risky decision-making. We review this body of work, investigate when and in what way findings converge, and provide best practice recommendations. We identified 23 studies that examined individual differences in brain responsivity and adolescent risk taking. Findings varied widely in terms of the neural regions identified as relating to risky behavior. This heterogeneity is likely due to the abundance of approaches used to assess risk taking, and to the disparity of fMRI tasks. Indeed, brain-behavior correlations were typically found in regions showing a main effect of task. However, results from a test of publication bias suggested that region of interest approaches lacked evidential value. The findings suggest that neural factors differentiating riskier teens are not localized to a single region. Therefore, approaches that utilize data from the entire brain, particularly in predictive analyses, may yield more reliable and applicable results. We discuss several decision points that researchers should consider when designing a study, and emphasize the importance of precise research questions that move beyond a general desire to address adolescent risk taking.
A novel post hoc method for detecting index switching finds no evidence for increased switching on the Illumina HiSeq X
Authors: Owens Gregory L. , Todesco Marco , Drummond Emily B. M. , Yeaman Sam , Rieseberg Loren H. 
Published: May 2017

AbstractHigh throughput sequencing using the Illumina HiSeq platform is a pervasive and critical molecular ecology resource, and has provided the data underlying many recent advances. A recent study has suggested that ‘index switching’, where reads are misattributed to the wrong sample, may be higher in new versions of the HiSeq platform. This has the potential to invalidate both published and in-progress work across the field. Here, we test for evidence of index switching in an exemplar whole genome shotgun dataset sequenced on both the Illumina HiSeq 2500, which should not have the problem, and the Illumina HiSeq X, which may. We leverage unbalanced heterozygotes, which may be produced by index switching, and ask whether the under-sequenced allele is more likely to be found in other samples in the same lane than expected based on the allele frequency. Although we validate the sensitivity of this method using simulations, we find that neither the HiSeq 2500 nor the HiSeq X have evidence of index switching. This suggests that, thankfully, index switching may not be a ubiquitous problem in HiSeq X sequence data. Lastly, we provide scripts for applying our method so that index switching can be tested for in other datasets.
A critical evaluation of the “short stay project” – service users’ perspectives
Authors: Brown Helen , Howlett Fiona 
Published: May 2017

Purpose
The purpose of this paper is to critically evaluate an innovative collaboration between health, housing and social care by exploring the “short stay project” apartments from service users’ perspectives and considering the effectiveness of this service model as part of enabling provision locally.

Design/methodology/approach
The qualitative methodology for this evaluation was interpretative phenomenological analysis (Smith, 2011), critically exploring service users’ personal lived experience of the “short stay project”. Three service users (n=3) participated in semi-structured interviews.

Findings
This study has identified the “short stay project” can prevent admission into and facilitate discharge from care and health services by offering a temporary stay in self-contained, adapted accommodation. Service users found value in staying at the apartments for differing reasons. However, practitioners must address service users’ emotional and social needs as well as physical needs to reduce the risk of occupational deprivation.

Research limitations/implications
Sample size is not fully representative of the total population making transferability limited.

Practical implications
This research found there is demand for temporary housing provision for service users with health, housing and/or social care needs.

Social implications
Key drivers of demand for the service are social inequalities relating to homelessness, poverty and gender-based violence rather than the health-related issues that could have been expected. Further research into the development of effective integrated services which maximise service users’ wellbeing and occupational performance is recommended.

Originality/value
Service models which integrate health, housing and social care can be innovative and maintain service users’ independence and wellbeing in the community. Commissioners across health, housing and social care could utilise the Better Care Fund to deliver integrated services to meet rising demands.
Predicting hospitality firm failure: mixed sample modelling
Authors: Li Hui , Xu Yu-Hui , Yu Lean 
Published: May 2017

Purpose
Available information for evaluating the possibility of hospitality firm failure in emerging countries is often deficient. Oversampling can compensate for this but can also yield mixed samples, which limit prediction models’ effectiveness. This research aims to provide a feasible approach to handle possible mixed information caused by oversampling.

Design/methodology/approach
This paper uses mixed sample modelling (MSM) when evaluating the possibility of firm failure on enlarged hospitality firms. The mixed sample is filtered out with a mixed sample index through control of the noisy parameter and outliner parameter and meta-models are used to build MSM models for hospitality firm failure prediction, with performances compared to traditional models.

Findings
The proposed models are helpful in predicting hospitality firm failure in the mixed information situation caused by oversampling, whereas MSM significantly improves the performance of traditional models. Meanwhile, only partial mixed hospitality samples matter in predicting firm failure in both rich- and poor-information situations.

Practical implications
This research is helpful for managers, investors, employees and customers to reduce their hospitality-related risk in the emerging Chinese market. The two-dimensional sample collection strategies, three-step prediction process and five MSM modelling principles are helpful for practice of hospitality firm failure prediction.

Originality/value
This research provides a means of processing mixed hospitality firm samples through the early definition and proposal of MSM, which addresses the ranking information within samples in deficient information environments and improves forecasting accuracy of traditional models. Moreover, it provides empirical evidence for the validation of sample selection and sample pairing strategy in evaluating the possibility of hospitality firm failure.
Examine destination loyalty of first-time and repeat visitors at all-inclusive resorts
Authors: Yolal Medet , Chi Christina Geng-Qing , Pesämaa Ossi 
Published: May 2017

Purpose
The purpose of this study is to examine the factors that are likely to influence the loyalty behavior of first-time and repeat visitors to all-inclusive resorts.

Design/methodology/approach
Data were collected from first-time and repeat Russian tourists to Antalya, Turkey, utilizing a self-administered survey questionnaire. A total of 339 usable responses were obtained. A structural equation modeling approach was used to test the proposed model on the first-time and repeat visitors’ samples.

Findings
This study suggests that the effects of cognitive evaluation of the resort (service quality) channel through affective evaluation of the visitor experience (visitor satisfaction) before bolstering visitor loyalty. This study also shows that differences exist between the two groups of visitors – first time visitors value cognitive attributes more and rely more on cognitive evaluation.

Practical implications
Destination marketers and managers need to promote all aspects and attributes of a destination among all-inclusive vacationers by creating innovative and comprehensive marketing campaign. Due to the differences between first-time and repeat visitors, it is critical to differentiate the two groups in designing targeted marketing campaign and providing targeted service/product.

Originality value
All-inclusive resorts have attained substantial global presence and popularity over the past 40 years. However, guest satisfaction/loyalty studies in this particular context have not often been approached with the kind of statistical breadth and rigor presented herein. This study adds new information for the understanding of and marketing to the all-inclusive resort guest.
Country-of-operation and brand images: evidence from the Chinese hotel industry
Authors: Lee Seonjeong (Ally) , Oh Haemoon , Hsu Cathy H.C. 
Published: May 2017

Purpose
Building upon previous research on country-of-origin. This study aims to investigate whether the effects of country-of-origin extend to the hotel industry, based on associative network and signaling theories.

Design/methodology/approach
Based on a self-administered survey with tourists in China, this paper investigates antecedents and outcomes of hotel brand image and the moderating role of a hotel’s brand origin.

Findings
Results reveal country, city and industry images positively influence hotel brand image. Hotel brand image then influences price perception, quality perception and overall satisfaction.

Practical implications
Country-of-operation image remains a relevant, powerful predictor of brand image; thus, hotels need to carefully manage country-of-operation image.

Originality/value
This paper incorporates and establishes the role of country-of-operation image on hotel brand image.