bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world treatment patterns, biomarker testing, and clinical outcomes of metastatic non-small cell lung cancer patients in the immunotherapy era
Authors: Apter Lior , Sharman Moser Sarah , Arunachalam Ashwini , Gazit Sivan , Hoshen Moshe , Chodick Gabriel , Siegelmann-Danieli Nava 
Published: October 2024

BackgroundTreatment for first-line (1L) metastatic non-small cell cancer (mNSCLC) changed with the introduction of immunotherapy. We describe treatment utilization and clinical outcomes in a real-world mNSCLC cohort in a 2.7-million-member state-mandated health provider.MethodsNewly diagnosed mNSCLC patients initiating systemic anti-cancer treatment (January 2017–December 2020) were identified from the National Cancer Registry. Real-world time on treatment (rwToT) was defined as the length of time between the first and last administration date of treatment. Real-world overall survival (rwOS) was estimated using Kaplan–Meier analysis. Outcomes were assessed at a minimum of 6 months’ follow-up (cutoff: 30 June 2021).ResultsAmong 843 patients, 85% had adenocarcinoma (NSQ) and 15% had squamous cell carcinoma (SQ) histology: of these, 43% and 26% were women, median age was 67 and 69 years, and 55% and 48% had 0–1 ECOG performance status, respectively (missing: 27% and 30%, respectively). Median follow-up for the entire cohort was 27.1 months (95% CI: 24.7–29.6). NSQ patients with no known EGFR/ALK/ROS1 aberrations received PD-1 inhibitor monotherapy (PDM) (N = 147) or combination (PDC) (N = 194) or platinum-based chemotherapy (PBC, N = 133). Median rwToT was 4.5 (95% CI: 3.5–7.6), 5.2 (95% CI: 4.6–7.6), and 2.3 (95% CI: 2.1–3.0) months, respectively; for the subgroup of patients with ECOG PS 0–1, rwToT was 9.4 (95% CI: 5.0–20.8), 7.1 (95% CI: 5.0–10.1), and 2.9 (95% CI: 2.2–4.1) months, respectively. Median rwOS from 1L was 12.5 (95% CI: 9.9–17.9), 14.8 (95% CI: 10.5–19.4), and 9.1 (95% CI: 7.1–11.5) months; for the subgroup of patients with ECOG PS 0–1, median rwOS was 25.1 [95% CI: 14.9–not reached (NR)], 17.6 (95% CI: 14.3–NR), and 11.3 (95% CI: 9.2–21.3) months, respectively. For ECOG PS 0–1 and PD-L1 ≥50% patients, median rwOS was 25.1 months (95% CI: 13.9–NR) and NR for PDM and PDC, respectively. For ECOG PS 0–1 and PD-L1 &lt;50% patients, median rwOS was 14.3 (95% CI: 10.1–NR) and 11.2 (95% CI: 9.1–21.3) months for PDC and PBC, respectively.ConclusionOur real-world data support the benefit of single-agent PD-1 inhibitor monotherapy for patients with PD-L1 high expression or PD-1 inhibitor combination for all patients diagnosed with mNSCLC with no known EGFR/ALK/ROS1 aberrations, initiating 1L treatment.
Impacts of completely endophytic renal masses on perioperative, oncologic, and functional outcomes in robot-assisted partial nephrectomy: a systematic review and meta-analysis
Authors: Gu Han-xiao , Lv Jia , Liu Yi , Wang Hai-long 
Published: October 2024

BackgroundThe objective of this study was to perform a comprehensive pooled analysis aimed at comparing the efficacy and safety of robot-assisted partial nephrectomy (RAPN) between completely endophytic tumors (CERT) and non-completely endophytic tumors (non-CERT).MethodsThis study adhered rigorously to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to conduct a systematic review and meta-analysis. We performed a systematic search in the PubMed, Embase, Web of Science, and Cochrane Library databases, focusing on studies published in English up to May 2024. Our analysis primarily evaluated key outcomes, specifically perioperative, functional, and oncological outcomes.ResultsA total of 2126 patients across six studies were included in the analysis. Compared to non-CERT, CERT was associated with significantly higher rates of major complications (Odds Ratio [OR]: 2.47; 95% CI: 1.14 to 5.34; p = 0.02), longer warm ischemia times (Weighted Mean Difference [WMD]: 3.27 min; 95% CI: 0.61 to 5.39; p = 0.02), a greater decline in estimated glomerular filtration rate (eGFR) (WMD: 2.93 ml/min/1.73 m2; 95% CI: 0.75 to 5.11; p = 0.008), and relatively lower trifecta achievement rates (OR: 0.63; 95% CI: 0.41 to 0.96; p = 0.03). However, no statistically significant differences were observed between the two groups in terms of operative time, length of stay, blood loss, transfusion rates, intraoperative complications, overall complications, positive surgical margins, and local recurrence.ConclusionsAlthough CERT was associated with greater declines in eGFR and lower rates of trifecta achievement, it yielded perioperative, functional, and oncologic outcomes comparable to those of non-CERT in RAPN. Our findings suggest that RAPN for completely endophytic renal masses can achieve acceptable outcomes when performed in centers with substantial expertise in robotic surgery.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=555067, identifier CRD42024555067.
Recovery rate and predictors among children aged 6–59 months with severe acute malnutrition in Addis Ababa, Ethiopia: a retrospective follow-up study
Authors: Getahun Genanew Kassie , Andabo Wondimu Ayele , Shewamare Abraham , Birhanu Molla Yigzaw 
Published: October 2024

IntroductionSevere acute malnutrition (SAM) is a critical public health concern in Ethiopia, contributing to high morbidity and mortality rates among children. Despite the improvement in hospital coverage and the development of standardized WHO treatment guidelines, recent reviews indicated a wide range in recovery rates (34%–88%) due to several context-specific factors. Understanding the factors influencing the recovery time can help inform targeted interventions and improve the overall management of SAM cases. Therefore, this study aimed to assess the time to recovery and predictors of children aged 6–59 months with severe acute malnutrition in Addis Ababa, Ethiopia, in 2023.MethodsAn institutional-based retrospective follow-up study was conducted among children aged 6–59 months who were admitted to Tirunesh Beijing Hospital (TBH), Addis Ababa, Ethiopia, from July 2019 to June 2023. The Kaplan–Meir estimate and survival curve were used to compare the time to recovery using a log-rank test among different characteristics. A Cox proportional hazard regression analysis model was used to identify significant predictors of time to recovery. Finally, a p-value of &lt;0.05 was used to declare a significant association.ResultsThe median survival time to recovery was 17 (95% CI: 16.39–17.60) days, and the incidence rate of recovery from SAM was 37.8 per 1,000 child days. Moreover, exclusive breastfeeding [adjusted hazard ratio (aHR): 1.97, 95% CI: 1.45–2.68], amoxicillin provision (aHR = 1.62, 95% CI: 1.11–2.35), and deworming (aHR = 2.14, 95% CI: 1.48–3.09) were protective factors. However, complications at admission (aHR = 0.41, 95% CI: 0.23–0.73) and diarrhea during admission (aHR = 0.64, 95% CI: 0.45–0.91) were identified as risk factors of recovery from SAM.ConclusionThe time to recovery among the current study participants was low compared with the sphere standard. Besides, exclusive breastfeeding, complications at admission, diarrhea, amoxicillin provision, and deworming were independent predictors. Therefore, appropriate provision of routine medication and early management of medical comorbidity as per the national SAM management protocol can reduce the mortality of children with severe acute malnutrition significantly.
Alisol A inhibits and stabilizes atherosclerotic plaques by protecting vascular endothelial cells
Authors: Ma Yang , Song Dingzhong , Yuan Jie , Hao Wusi , Xi Jianqiang , Yuan Chunping , Cheng Zhihong 
Published: October 2024

Background and aimsDysfunction of endothelial cells represents a crucial aspect in the pathogenesis of atherosclerosis. The aim of this study was to explore the protective effects of alisol A on vascular endothelial cells and its possible mechanisms.MethodsAn atherosclerosis model was established by feeding ApoE-/- mice with high-fat chow. Alisol A (150 mg/kg/d) or atorvastatin (15 mg/kg/d) was administered, and the levels of blood lipids were evaluated. The effect of the drugs on atherosclerotic plaques was observed by staining the aorta with Sudan IV. In vitro experiments were conducted using human aortic endothelial cells (HAECs) to assess the effects of alisol A on cell proliferation, migration, tubulation, secretion, and cellular integrity by CCK-8 assay, wound healing assay, angiogenesis assay, NO secretion, and release of LDH. Transcriptomics and molecular docking were used to explore the mechanism of plaque inhibition and stabilization by alisol A.ResultsAlisol A significantly reduced the aortic plaque area in ApoE−/− mice fed with high-fat chow. In vitro, alisol A had a protective effect on HAECs, which was reflected in the inhibition of vascular endothelial cell proliferation, promotion of NO secretion by vascular endothelial cells, inhibition of vascular endothelial cell migration and angiogenesis, and the maintenance of cell membrane integrity. Therefore, alisol A inhibited and stabilized atherosclerotic plaques and slowed down the process of atherosclerosis. Transcriptomics studies showed 4,086 differentially expressed genes (DEGs) in vascular endothelial cells after alisol A treatment. Enrichment analysis indicated that many genes involved in TNF signaling pathway were differentially expressed, and inflammatory genes were suppressed. The molecular docking results verified the hypothesis that alisol A has a low binding energy after docking with TNF target, and TNF could be a potential target of alisol A.ConclusionAlisol A produced protection on vascular endothelial cells, achieving inhibition and stabilization of atherosclerotic plaques.
The impact of job stress on job satisfaction and turnover intentions among bank employees during the COVID-19 pandemic
Authors: Lin Mei-Hui , Yen Ya-Hui , Chuang Tsai-Fu , Yang Ping-Sen , Chuang Ming-Da 
Published: October 2024

ObjectiveThe main objective of this study is to explore the relationships among job stress, job satisfaction, and turnover intentions among bank employees during the COVID-19 pandemic, with a focus on variations across different demographic characteristics.MethodsA cross-sectional design was employed, and data were collected from 501 bank employees using the Job Stress Questionnaire (JSQ), the Simplified Minnesota Satisfaction Questionnaire (MSQ), and the Intention to Leave Scale (ILS). Descriptive statistics, t-tests, ANOVA, Pearson correlation, and multiple regression analyses were used to test the research hypotheses.ResultsThe findings show that job stress is significantly negatively correlated with job satisfaction and positively correlated with turnover intention. Interpersonal relationship stress emerged as the strongest predictor of turnover intention, while job autonomy stress significantly influenced job satisfaction. Demographic factors, including age, income, and education level, moderated these relationships, with younger, higher-income, and more educated employees reporting lower stress and higher satisfaction. Employees with dependents reported higher stress levels, lower job satisfaction, and greater turnover intentions compared to those without dependents.ConclusionThis study underscores the importance of managing workplace stress and enhancing job satisfaction to reduce turnover intention, particularly during the COVID-19 pandemic. Interventions focused on improving interpersonal relationships and providing targeted support for older and lower-income employees are recommended to mitigate stress and improve retention rates.
Prevalence of psychiatric disorders among the adult population in a rural community of Jammu, India: a cross-sectional study
Authors: Bailam Sandeepa , Sudershan Amrit , Sheetal  , Younis Mohd , Arora Manu , Kumar Hardeep , Kumar Parvinder , Kumar Dinesh 
Published: October 2024

BackgroundMental health is crucial for overall well-being, but rural areas often face difficulties in accessing mental health services and understanding psychiatric disorders.AimThis study aimed to address these issues by assessing the prevalence of psychiatric disorders among adults in rural Jammu and examining how socio-cultural and demographic factors are related to these disorders.MethodsA sample of 1,016 adults from rural Jammu was surveyed using the Mini International Neuropsychiatric Interview (MINI). Data were collected through house-to-house visits conducted by trained investigators. Descriptive and inferential statistics, including frequency distribution and odds ratio, were employed to analyze the data respectively.ResultsOverall, 20.67% of the participants had a psychiatric disorder. Alcohol dependence was the most common condition, affecting 12.30% of the individuals, followed by generalized anxiety disorder at 3.14%. The study found significant associations between psychiatric disorders and several factors. Specifically, older people were more likely to have psychiatric disorders, with an odds ratio of 3.7 [2.07-6.59]. Married individuals also had a higher likelihood of experiencing psychiatric disorders (OR: 2.3 [1.55-3.54]). Those with less schooling were at an increased risk, with an odds ratio of 7.77 [2.31-26.09], and people from lower socioeconomic backgrounds were more likely to have these disorders as well (OR: 5.1 [2.4-10.5]).Discussion and conclusionThe findings underscore the complex association between socio-demographic factors and mental health outcomes in rural areas of Jammu region. Addressing these disparities requires targeted interventions and policies that account for the unique socio-cultural contexts of rural populations. By understanding the specific challenges faced by these communities, policymakers and healthcare providers can develop more effective strategies to enhance mental health services and promote well-being.
Mental health disorder in chronic liver disease: a questionnaire survey
Authors: Long Jiang , Pei Xiong , Jiang Wei , Wang Xiaoling , Wu Dongbo , Tang Xiangdong , Zhou Taoyou 
Published: October 2024

BackgroundThe mental health of patients with chronic liver disease (CLD) warrants greater attention and understanding, especially concerning its risk factors.MethodPatients from our hospital’s hepatology clinic were consecutively enrolled and completed a questionnaire assessing anxiety, depression, and sleep quality using the GAD-7, PHQ-9, and PSQI scales, respectively. Reliability and validity were evaluated with Cronbach’s α and Kaiser-Meyer-Olkin (KMO). Continuous and categorical variables were analyzed using the Mann-Whitney U and Chi-square tests. Univariate and multivariate logistic regression were used to identify risk factors, while restricted cubic spline (RCS) were used to explored non-linear associations. Subgroup analyses were stratified by sex, age, and education.ResultA total of 1030 questionnaires were collected, and after quality control, 1003 were included. 56.2% (564/1003), 53.2% (534/1003), and 67.4% (676/1003) individuals had anxiety, depression, and sleep disorders. Differences in age, gender, and education level were observed (P&lt;0.05). Subgroup analysis showed similar demographic trends. Univariate and multivariate regression analysis found age negatively correlated with anxiety (OR=0.98, 95%CI=0.97-0.99, P=0.02) and depression (OR=0.98, 95%CI=0.96-0.99, P&lt;0.001), but positively correlated with sleep disorders (OR=1.03, 95%CI= 1.01-1.05, P&lt; 0.001); males are less prone to anxiety (OR=0.68, 95%CI=0.52-0.88, P=0.004) and sleep disorders (OR=0.72, 95%CI: 0.55-0.94, P=0.02); university degree is more susceptible to depression (OR=1.36, 95%CI=1.04-1.77, P=0.02) and anxiety (OR=1.45, 95%CI=1.11-1.89, P=0.007). RCS analysis suggested a linear relationship between the age and affective disorders among different population.ConclusionYoung individuals, female, and those with higher education are more vulnerable to mental health, warranting increased attention.
A significant and persistent rise in the global burden of adolescent NAFLD and NASH estimated by BMI
Authors: Lin Xiao-Yun , Li Jing-Mao , Huang Ling-Yi , Lin Li-Yan , Hong Mei-Zhu , Weng Shangeng , Pan Jin-Shui 
Published: October 2024

BackgroundCurrently, there is a lack of global or even country/regional level data on adolescent non-alcoholic fatty liver disease (NAFLD) prevalence. However, an evidenced dose-dependent relationship exists between body mass index (BMI) and the risk of NAFLD. We aim to estimate the global and regional prevalence of adolescent NAFLD and related non-alcoholic steatohepatitis (NASH) based on BMI.MethodsSigmoidal fitting curves were generated between BMI and the risk of NAFLD/NASH using the data extracted from the NHANES database. With global and regional BMI data from the NCD-RisC database, adolescent NAFLD/NASH prevalence was estimated at the international, regional, and country levels from 1975 to 2016. The prevalence of adolescent NAFLD/NASH from 2017 to 2030 was also forecasted.ResultsThe mean NAFLD prevalence was 15.31, and 12.68%, while the mean NASH prevalence was 2.50, and 2.47%, in boys, and girls aged 12–18, respectively. For both boys and girls, NAFLD/NASH prevalence increased with increasing BMI, and age. The global prevalence of adolescent NAFLD/NASH has gradually increased in the period from 1975 to 2016 and will maintain a similar trend between 2017 and 2030. High-income Western Countries had higher adolescent NAFLD/NASH whereas South Asia and Sub-Saharan Africa exhibited relatively lower adolescent NAFLD/NASH prevalence. The estimated annual percentage change (EAPC) of NAFLD prevalence in boys ranged from 0.72% (age 18) to 1.16% (age 12) while that in girls ranged from 0.69% (age 18) to 0.92% (age 12). EAPC of NASH prevalence in boys ranged from 1.65% (age 18) to 1.77% (age 12), and in girls from 1.48% (age 18) to 1.68% (age 12).ConclusionThe adolescent NAFLD/NASH prevalence increases year by year, and its burden varies significantly among different countries and regions. BMI is a precise predictor of NAFLD/NASH prevalence.
A social norms campaign based positive intervention aimed at promoting protective behaviours
Authors: Cuadrado Esther , Arenas Alicia , Tabernero Carmen , Maldonado Miguel A. 
Published: October 2024

IntroductionSocial norms campaigns are communication strategies designed to influence people’s behaviour by highlighting the social norms of their reference group. Such campaigns have been shown to be effective in promoting healthy behaviours in a variety of settings. This study explored the effectiveness of a social norms campaign applied to COVID-19 protective behaviours among university students during the pandemic.MethodsA total of 141 university students (83.1% female, 16.9% male) with a mean age of 21.55 years (SD = 4.33) initially took part in an experimental pre-test-post-test longitudinal panel study between January and July 2022, with participants randomly assigned to a control group (46 participants) or an experimental group (95 participants). Considering the experimental attrition, only 83 participants completed the last questionnaire (81.9% female, 18.1% male; mean age = 22.12 years, SD = 5.29), of whom 32 belonged to the control group and 51 to the experimental group.ResultsThe Student’s t-test show that participants in the experimental group, who were exposed to the campaign, reported higher levels of self-efficacy, protective behavioural intention, and protective behaviours than the control group.DiscussionIt is concluded that social norms campaigns applied to COVID-19 protective behaviours are effective in times of pandemic and might be extrapolated to other epidemic contexts.
The influence of physical exercise on adolescents’ externalizing problem behaviors: mediating effects of parent–child relationships, self-esteem, and self-control
Authors: Cui Long , Xing Yumei , Gu Jixing , Zhou Hao , Zhang Lin , Bu Yifeng 
Published: October 2024

BackgroundExternalizing problem behaviors can significantly and negatively impact adolescents’ learning, daily life, and future socialization. While physical exercise is believed to inhibit adolescents’ externalizing problem behaviors, the extent of its effect and the mediating mechanisms remain unclear.MethodsThis study is based on data from the 2018 China Family Panel Studies (CFPS). The CFPS project employed the Externalizing Problem Behaviors Scale (EPBS), the Rosenberg Self-Esteem Scale (RSES), and the Self-Control Scale (SCS) to measure adolescents’ externalizing problem behaviors, self-esteem, and self-control. Additionally, physical exercise was measured by collecting data on the time and frequency of adolescents’ physical exercise. Parent-child relationships were evaluated using a composite variable that included four dimensions: frequency of quarrels, frequency of heart-to-heart talks, parental awareness of their children’s whereabouts, and children’s trust in their parents. Based on data collection and variable construction, this study employed multiple linear regression, propensity score matching, and quantile regression to analyze the impact of physical exercise on adolescents’ externalizing problem behaviors and the heterogeneity of these effects. Additionally, the Bootstrap mediation effect test was employed to explore the mediating roles of parent-child relationships, self-esteem, and self-control in this process.ResultsThe analysis demonstrates that physical exercise significantly inhibits adolescents’ externalizing problem behaviors (β = −0.095, p &lt; 0.01), although the effect varies significantly among different populations. Compared to males (β = −0.077, p &lt; 0.1), rural residents (β = −0.065, p &gt; 0.1), individuals with poorer family economic status (β = −0.080, p &lt; 0.1), and those with more severe problem behaviors (τ = 0.75, β = −0.086, p &lt; 0.05), physical exercise yields a more pronounced inhibitory effect on females (β = −0.113, p &lt; 0.01), urban residents (β = −0.134, p &lt; 0.01), individuals with better family economic status (β = −0.115, p &lt; 0.01), and those with milder problem behaviors (τ = 0.25, β = −0.112, p &lt; 0.01). Furthermore, through enhancements in parent-child relationships (CI: -0.015; -0.002), self-esteem (CI: -0.019; -0.003), and self-control (CI: -0.055; -0.025), physical exercise indirectly mitigates adolescents’ externalizing problem behaviors.ConclusionPhysical exercise significantly reduces adolescents’ externalizing problem behaviors, with effects differing across various groups. Parent-child relationships, self-esteem, and self-control mediate this relationship, underscoring the positive influence of exercise on adolescent behavior.