bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comment: African Arts and Social Control
Authors: Bascom William 
Published: February 2017

I am delighted with the manner in which these three papers have dealt with the social and political relevance of sculpture, folklore, and music. This is no startlingly new discovery. It has been recognized before by those interested in the arts, but it has been largely ignored by those who specialize in social and political studies. The contributors to this panel are to be congratulated for their documentation of this function of the arts, and our chairman deserves special recognition for this attempt to bring it to the attention of those who so often overlook it.
The panelists have stressed the lessons to be learned by the social scientists, but I wonder if there is not one for the humanists as well. The fact that artists are often rebels against the status quo is a truism in our society, but the significance of the arts as a medium of social and political action, and of change, is often ignored although similar examples can be found in Africa today as well as in the history of other societies.
Where does this leave our conventional definitions of art as aesthetic expression, as creativity, as “art for art's sake,” as concern with form for its own sake, or as elaboration beyond the point of utility? All these, I fear, underevaluate the socio-political utility of art which these papers have demonstrated in their different fields.
Federalism in Switzerland
Authors: Bogdanor Vernon 
Published: February 2017

‘FEDERALISM’, CLAIMED THE SWISS PHILOSOPHER, DENIS DE Rougemont, ‘rests upon thelove of complexity, by contrast with the brutal simplicity which characterises the totalitarian spirit’. It would be hard to deny that complexity is the most striking feature of federal government in Switzerland. To comprehend it fully, one would have to analyse the history, politics and atmosphere of each of the twenty-six cantons, for each is a political system in itself; and there is no such animal as a ‘typical’ canton. Political scientists have studied one or two cantons in some depth, and there are also impressionistic accounts of cantonal life, but there is no really satisfactory comparative analysis of the cantons as a whole. Further, many Swiss cantons are ‘closed' societies, difficult for the foreigner to penetrate and not easily accessible to the academic inquirer. The political scientist needs to acquire the skills of the anthropologist in addition to those of the analyst of political institutions if he is to make headway. It is difficult, therefore, to give anything more than a very general impression of the principles lying behind federal government in Switzerland, an impression which is bound to be, to some degree at least, misleading. For of no country more than Switzerland is it more correct to say that the truth lies in the minute particulars and not in generalities.The complexity of Swiss federalism is a consequence of the fact that the Swiss have embraced more completely than any other democracy that essential principle, the leitmotiv, of federalism — the sharing of power. Switzerland is indeed an extreme example of federalism, just as it is an extreme example of the application of the principles of democracy and of neutrality in foreign affairs.
Tongue–lip adhesion and tongue repositioning for obstructive sleep apnoea in Pierre Robin sequence: A systematic review and meta-analysis
Authors: Camacho M , Noller M W , Zaghi S , Reckley L K , Fernandez-Salvador C , Ho E , Dunn B , Chan D K 
Published: February 2017

AbstractObjective:To search for studies on tongue–lip adhesion and tongue repositioning used as isolated treatments for obstructive sleep apnoea in children with Pierre Robin sequence.Methods:A systematic literature search of PubMed/Medline and three additional databases, from inception through to 8 July 2016, was performed by two authors.Results:Seven studies with 90 patients (59 tongue–lip adhesion and 31 tongue repositioning patients) met the inclusion criteria. Tongue–lip adhesion reduced the mean (± standard deviation) apnoea/hypopnoea index from 30.8 ± 22.3 to 15.4 ± 18.9 events per hour (50 per cent reduction). The apnoea/hypopnoea index mean difference for tongue–lip adhesion was −15.28 events per hour (95 per cent confidence interval = −30.70 to 0.15;p= 0.05). Tongue–lip adhesion improved the lowest oxygen saturation from 75.8 ± 6.8 to 84.4 ± 7.3 per cent. Tongue repositioning reduced the apnoea/hypopnoea index from 46.5 to 17.4 events per hour (62.6 per cent reduction). Tongue repositioning improved the mean oxygen saturation from 90.8 ± 1.2 to 95.0 ± 0.5 per cent.Conclusion:Tongue–lip adhesion and tongue repositioning can improve apnoea/hypopnoea index and oxygenation parameters in children with Pierre Robin sequence and obstructive sleep apnoea.
Otolaryngology outreach to Komfo Anokye Teaching Hospital: a medical and educational partnership
Authors: Waller B , Larsen-Reindorf R , Duah M , Opoku-Buabeng J , Edwards B M , Brown D , Moyer J , Prince M , Basura G J 
Published: February 2017

AbstractBackground:Medical and educational partnerships between high- and low-resourced countries provide opportunities to have a long-term meaningful impact on medical training and healthcare delivery.Methods:An otolaryngology partnership between Komfo Anokye Teaching Hospital in Kumasi, Ghana, and the University of Michigan Department of Otolaryngology/Head and Neck Surgery has been undertaken to enhance healthcare delivery at both institutions.Results:A temporal bone dissection laboratory, with the equipment to perform dedicated otological surgery, and academic platforms for clinical and medical education and residency training have been established.Conclusion:This article describes the details of this partnership in otological surgery and hearing health, with an emphasis on creating in-country surgical simulation, training on newly acquired medical equipment and planning regarding the formulation of objectified metrics to gauge progress going forward.
Depressive symptoms and inflammation are independent risk factors of fatigue in breast cancer survivors
Authors: Xiao C. , Miller A. H. , Felger J. , Mister D. , Liu T. , Torres M. A. 
Published: February 2017

BackgroundPsychosocial and inflammatory factors have been associated with fatigue in breast cancer survivors. Nevertheless, the relative contribution and/or interaction of these factors with cancer-related fatigue have not been well documented.MethodThis cross-sectional study enrolled 111 stage 0–III breast cancer patients treated with breast surgery followed by whole breast radiotherapy. Fatigue was measured by the total score of the Multidimensional Fatigue Inventory-20. Potential risk factors included inflammatory markers (plasma cytokines and their receptors and C-reactive protein; CRP), depressive symptoms (as assessed by the Inventory of Depressive Symptomatology–Self Reported), sleep (as assessed by the Pittsburgh Sleep Quality Index) and perceived stress (as assessed by the Perceived Stress Scale) as well as age, race, marital status, smoking history, menopause status, endocrine treatment, chemotherapy and cancer stage. Linear regression modeling was employed to examine risk factors of fatigue. Only risk factors with a significance level <0.10 were included in the initial regression model. A post-hoc mediation model using PROCESS SPSS was conducted to examine the association among depressive symptoms, sleep problems, stress, inflammation and fatigue.ResultsAt 1 year post-radiotherapy, depressive symptoms (p<0.0001) and inflammatory markers (CRP: p = 0.015; interleukin-1 receptor antagonist: p = 0.014; soluble tumor necrosis factor receptor-2: p = 0.009 in separate models) were independent risk factors of fatigue. Mediation analysis showed that depressive symptoms also mediated the associations of fatigue with sleep and stress.ConclusionsDepressive symptoms and inflammation were independent risk factors for cancer-related fatigue at 1 year post-radiotherapy, and thus represent independent treatment targets for this debilitating symptom.
Yearning for the Spiritual Ideal: The Influence of India on Western Dance 1626–2003
Authors: Warren Vincent 
Published: February 2017

Europeans have imagined India as a land of fabulous riches and exotic legends since the time of ancient Greece. In Greek mythology Dionysus, the god of passion and wine, was said to have come from India, and Alexander the Great's proudest achievement was arriving at the banks of the Indus. When, after 1498, explorers from Portugal, Holland, England, Denmark, and France began to establish trade links with the subcontinent, it seemed the legends were true; rare spices, silks, gold, and precious stones were transported to Europe and added fuel to already inflamed imaginations. The very name of the city of Golconda became a synonym for unimaginable wealth. There was confusion between all things exotic or “oriental.” Turks, Africans, Persians, American “Indians,” and Caribbeans were all from the same imaginary region, “the Indies,” which existed more in the poetic fantasies of Europeans than on a geographical map.As early as 1626 at the court of Louis XIII, king of France, the mysterious figure of Asia appeared in the Grand Bal de la Douairière de Billebahaut, a ballet danced by the king and his noble companions. In 1635 The Temple of Love, a court masque (as le ballet du cour was known in England), was presented at Whitehall Palace in London. In this spectacle, Persian youths voyaged to India to encounter Indamora, Queen of Narasinga, danced by Queen Henrietta Maria herself in a costume designed by Inigo Jones. Back in France, a Sanjac Indien represented the continent of Asia in another court ballet, Les Entretiens de la Fontaine de Vaucluse (1649).
A Case-Control Study of Maternal Gestational Weight Gain and Newborn Birthweight and Birthlength in Twin Pregnancies Complicated by Preeclampsia
Authors: Luke B. , Keith L. , Lopez-Zeno J.A. , Witter F.R. , Saquil E. 
Published: February 2017

AbstractTo evaluate the influence of rate of gestational weight gain on newborn birthweight and birthlength in twin gestations complicated by preeclampsia, 74 cases of preeclampsia in twin pregnancy were matched to 148 non-preeclamptic twin controls for maternal race, height, pregravid weight, age and length of gestation. Total weight gain was significantly higher for all cases versus controls and for mild cases versus controls. However, the rate of early weight gain was lower for severe cases and severe cases with thrombocytopenia compared to their controls. Mean birthweight and birthlength did not differ between cases and controls, although the proportion with birthlength below the 10th percentile was significantly higher among cases than controls. In addition, the proportion of birthweights and birthlengths < 10th percentile was significantly higher among cases than controls. These findings suggest that inadequate early weight gain in twin gestations complicated by preeclampsia results in retarded birthlength and birthweight. The implication of these findings are discussed.
Size for Gestational Age and Neonatal Sleep Variables: Behavioral Indices of Risk in Fullterm Twins
Authors: Riese M.L. 
Published: February 2017

AbstractNeonatal sleep behaviors and behavioral state cycling were observed for 20 pairs of same-sex, fullterm twins in which one twin of the pair was appropriate-for-gestational-age (AGA) and the other twin was small-for-gestational-age (SGA). Time-sampling recordings were made in active sleep of number and vigor of limb movements, body and head movements, and mouth movements. No group differences were observed for time spent in first active sleep, first quiet sleep, or length of first sleep cycle. Examination of specific behaviors indicated a significantly higher incidence of vigorous limb movements and right hand-to-mouth movements, with a trend for more small limb movements and left hand-to-face movements, for AGA twins when compared with SGA twins. SGA twins had significantly more spontaneous smiles and a trend for more spontaneous startles than AGA twins. A stepwise discriminant analysis indicated that a composite of the variables smile, large limb movement, startle, and left hand-to-face significantly discriminated between the two groups, with 90% correct classification of the AGA twins and 75% correct classification of the SGA twins. The results demonstrated the utility of evaluating specific sleep behaviors, rather than state cycling only, to describe differences in neonatal sleep characteristics between AGA and SGA twins.
Cerebrotendinous Xanthomatosis Presenting with Severe Externalized Disorder:Improvement After One Year of Treatment with Chenodeoxycholic Acid
Authors: Bonnot Olivier , Fraidakis Matthew J. , Lucanto Raffaella , Chauvin Dominique , Kelley Nathalie , Plaza Monique , Dubourg Odile , Lyon-Caen Olivier , Sedel Frédéric , Cohen David 
Published: February 2017

ABSTRACTCerebrotendinous xanthomatosis (CTX) is a rare inborn disorder of sterol storage with autosomal recessive inheritance and a variable clinical presentation. We describe two siblings with an early psychiatric presentation of CTX-associated attention-deficit/hyperactivity disorder and oppositional defiant disorder, also associated with a mild intellectual disability and major behavioral impairments. In both cases, treatment with chenodeoxycholic acid improved externalized symptoms and a partial recovery of cognitive impairments was observed. This suggests that CTX is potentially reversible, demonstrating the need for early diagnosis and treatment of this disorder before irreversible neurological lesions can occur.
Duration of Untreated Psychosis and Duration of Untreated Illness: New Vistas
Authors: Dell'Osso Bernardo , Altamura A. Carlo 
Published: February 2017

ABSTRACTThe duration of untreated illness (DUI), defined as the interval between the onset of a psychiatric disorder and the administration of the first pharmacological treatment, has been increasingly investigated in the last decade as a predictor of outcome across different psychiatric conditions including schizophrenia and psychotic disorders (duration of untreated psychosis), and mood and anxiety disorders. Converging evidence indicates that a prolonged DUI may be viewed as a negative prognostic factor in schizophrenia and increasing data point toward a similar conclusion in mood and anxiety disorders. Through a Medline search, the present article highlights the role of the DUI in this group of psychiatric disorders, focusing on social and psychopathological determinants of the DUI, as well as the clinical consequences related to a longer DUI in terms of outcome. Hypotheses on neurobiological mechanisms underpinning outcome differences in relation to a prolonged DUI are provided and methodological limitations related to the assessment of the DUI in published studies and clinical practice discussed. Finally, given that DUI is supposed to be a potentially modifiable prognostic factor, intervention programs aimed to reduce this variable are briefly considered and discussed.
Quality of Life in Parkinson's Disease Patients Following Adjunctive Tolcapone Therapy: Results of an Open-Label, Multicenter, Community-Based Trial
Authors: Sethi Kapil , Factor Stewart , Watts Ray 
Published: February 2017

ABSTRACTObjective: To examine changes in quality of life (QOL) and global clinical status after 30 days of adjunctive treatment with tolcapone, a reversible inhibitor of catechol-O-methyltransferase, in patients with fluctuating Parkinson's disease.Methods: This 30-day, multicenter, open-label, community-based study enrolled fluctuating Parkinson's disease patients to receive tolcapone 100 mg TID as an adjunct to levodopa/carbidopa. The primary end point was QOL change assessed using the Parkinson's Disease Questionnaire (PDQ)-8. Clinical change was assessed using the investigator-rated Clinical Global Impression of Improvement Scale (CGI-I).Results: Fifty-six physicians enrolled 202 patients; 138 (68%) were ≥65 years of age and 116 (57%) had Parkinson's disease for ≥5 years. The mean PDQ-8 total score improved from 42.1 to 34.8 after 30 days of tolcapone (P<.0001). Sixty-nine percent of patients improved on the CGI-I. Physicians planned to continue tolcapone beyond the 30 days in 72%, most commonly because of positive changes in motor function and overall general improvement. No patient discontinued because of liver adverse events.Conclusions: Adjunctive tolcapone treatment was associated with statistically significant improvement in QOL in fluctuating Parkinson's disease patients. A majority of patients experienced clinical benefits and continued treatment beyond the end of this study. No liver-related adverse events were reported.
Correction of Venlafaxine- and Duloxetine-Induced Transaminase Elevations with Desvenlafaxine in a Patient with Gilbert's Syndrome
Authors: Feinberg S. Shalom 
Published: February 2017

ABSTRACTRecent reviews have questioned whether the serotonin-norepinephrine reuptake inhibitor (SNRI) desvenlafaxine succinate offers any practical clinical advantages over existing SNRIs. The following case is one instance where it appears that this SNRI offers unique safety and benefit. Presented is a case report of a patient with Gilbert's syndrome, longstanding social phobia, and more recent depressive disorder not otherwise specified, who was found to have elevated liver transaminases when prescribed both duloxetine and venlafaxine. The patient subsequently responded to desvenlafaxine but without liver abnormalities. In this patient with Gilbert's Syndrome, desvenlafaxine's lack of metabolism through the cytochrome P450 (CYP) 2D6 pathway may explain the avoidance of these abnormalities and thus suggests a possible therapeutic role for this SNRI in similarly susceptible patients.
One-Year Open-Label Safety and Efficacy Study of Paliperidone Extended-Release Tablets in Patients With Schizophrenia
Authors: Kramer Michelle , Simpson George , Maciulis Valentinas , Kushner Stuart , Liu Yanning , Lim Pilar , Hough David , Palumbo Joseph , Eerdekens Mariëlle 
Published: February 2017

ABSTRACTIntroduction: This 52-week open-label extension (OLE) to a double-blind placebo-controlled recurrence prevention study examined the long-term safety and efficacy of flexibly-dosed paliperidone extended-release (ER) tablets in patients with schizophrenia.Methods: Patients entering the OLE either entered from the double-blind phase (placebo or paliperidone ER treatment) or entered directly from the run-in or stabilization phase (paliperidone ER) of the earlier study. During the OLE, patients were treated with flexibly-dosed paliperidone ER (3–15 mg/day; 9 mg starting dose). Safety and tolerability assessments included incidence of adverse events and extrapyramidal symptoms. Efficacy was also assessed.Results: The study population (n=235) was predominantly men (66%), 18–58 years of age. Twelve patients (5%) experienced an adverse event requiring treatment discontinuation. One or more serious treatment-emergent adverse events were reported in 13 patients (6%). There was one death. The mean Positive and Negative Syndrome Scale total score decreased from open-label baseline to endpoint for all groups, regardless of previous double-blind treatment (placebo or paliperidone ER).Conclusion: This year-long OLE provides information on the long-term safety and tolerability of paliperidone ER in patients with schizophrenia. The resulting safety and tolerability profile was similar to that seen in earlier short-term studies.
Rivastigmine and Concomitant Memantine in Alzheimer's Disease: Safety and Tolerability
Authors: Safirstein Beth , Meng Xiangyi , Olin Jason T. 
Published: February 2017

ABSTRACTBackground: Investigate the safety and tolerability of rivastigmine capsules and transdermal patch in patients with moderate Alzheimer's disease receiving concomitant memantine.Methods: Safety data from two prospective, open-label, multicenter trials were analyzed. Study US32: patients received rivastigmine capsules (3–12 mg/day) plus memantine (20 mg/day). Study US38: patients switched from donepezil to rivastigmine patches (4.6 mg/24 hours) immediately or following 7 days' withdrawal; ∼50% received concomitant memantine (20 mg/day).Results: The rivastigmine patch demonstrated more favorable tolerability than rivastigmine capsules, being associated with fewer adverse events (AEs) (73% versus 83%), serious AEs (10% versus 23%) and gastrointestinal symptoms (4% versus 26% for nausea; 4% versus 11% for vomiting). Application site reactions occurred in 17% of patients.Conclusion: Concomitant memantine treatment with rivastigmine patch and capsule is generally well tolerated. The favorable tolerability and safety profile of rivastigmine transdermal patch is not further improved with concomitant memantine. Recommendations to minimize application site reactions are provided.
Pharmacologic Treatment of Epilepsy
Authors: Fountain Nathan B. , Cole Andrew J. 
Published: February 2017

A 64-year-old man had a first generalized seizure. He was seen in an emergency room where magnetic resonance imaging revealed a right parietal meningioma with a diameter of 2.5 cm. He was seen by the neurosurgery team and a craniotomy was performed. He was discharged from the hospital on phenytoin. Three weeks later he reported drowsiness and unsteadiness to his neurologist. In addition, he described episodes of transient sensory disturbance in his left arm, sometimes with twitching movements of the left hand and wrist. These episodes could last ≤3 minutes, and his hand and arm would be weak afterward for several hours. A phenytoin level was measured at 17. Lamotrigine was added to his regimen, and on 400 mg/day the lamotrigine level was 3.8. The dose was increased gradually to 400 mg BID and seizures stopped. Two hours after each dose, however, the patient would become dizzy, nauseated, and encephalopathic for a period of 60–90 minutes.The patient presented with a convulsive seizure due to a meningioma and developed simple partial sensorymotor seizures arising in the region of the meningioma after its resection. The seizures persisted with phenytoin at a moderately high serum level but responded to lamotrigine as a second agent at just above the maximum tolerated dose. This case illustrates a common course of events for otherwise healthy adults who have seizures due to structural brain disease and are placed on phenytoin and lamotrigine.
A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity
Authors: Lee Yen-Chun , Patil Sumersing , Golz Christopher , Strohmann Carsten , Ziegler Slava , Kumar Kamal , Waldmann Herbert 
Published: February 2017

AbstractThe selective transformation of different starting materials by different metal catalysts under individually optimized reaction conditions to structurally different intermediates and products is a powerful approach to generate diverse molecular scaffolds. In a more unified albeit synthetically challenging strategy, common starting materials would be exposed to a common metal catalysis, leading to a common intermediate and giving rise to different scaffolds by tuning the reactivity of the metal catalyst through different ligands. Herein we present a ligand-directed synthesis approach for the gold(I)-catalysed cycloisomerization of oxindole-derived 1,6-enynes that affords distinct molecular scaffolds following different catalytic reaction pathways. Varying electronic properties and the steric demand of the gold(I) ligands steers the fate of a common intermediary gold carbene to selectively form spirooxindoles, quinolones or df-oxindoles. Investigation of a synthesized compound collection in cell-based assays delivers structurally novel, selective modulators of the Hedgehog and Wnt signalling pathways, autophagy and of cellular proliferation.