bluuebunny/crossref_metadata_2025_split huggingface dataset:
What role for libraries in learning analytics?
Authors: Jantti Margie , Heath Jennifer 
Published: August 2016

Purpose
– The purpose of this paper is to provide an overview of the development of an institution wide approach to learning analytics at the University of Wollongong (UOW) and the inclusion of library data drawn from the Library Cube.

Design/methodology/approach
– The Student Support and Education Analytics team at UOW is tasked with creating policy, frameworks and infrastructure for the systematic capture, mapping and analysis of data from the across the university. The initial data set includes: log file data from Moodle sites, Library Cube, student administration data, tutorials and student support service usage data. Using the learning analytics data warehouse UOW is developing new models for analysis and visualisation with a focus on the provision of near real-time data to academic staff and students to optimise learning opportunities.

Findings
– The distinct advantage of the learning analytics model is that the selected data sets are updated weekly, enabling near real-time monitoring and intervention where required. Inclusion of library data with the other often disparate data sets from across the university has enabled development of a comprehensive platform for learning analytics. Future work will include the development of predictive models using the rapidly growing learning analytics data warehouse.

Practical implications
– Data warehousing infrastructure, the systematic capture and exporting of relevant library data sets are requisite for the consideration of library data in learning analytics.

Originality/value
– What was not anticipated five years ago when the Value Cube was first realised, was the development of learning analytic services at UOW. The Cube afforded University of Wollongong Library considerable advantage: the framework for data harvesting and analysis was established, ready for inclusion within learning analytics data sets and subsequent reporting to faculty.
Feasibility of borehole ambient noise interferometry for permanent reservoir monitoring
Authors: Behm M. 
Published: August 2016

ABSTRACTThe analysis of seismic ambient noise acquired during temporary or permanent microseismic monitoring campaigns (e.g., improved/enhanced oil recovery monitoring, surveillance of induced seismicity) is potentially well suited for time‐lapse studies based on seismic interferometry. No additional data acquisition required, ambient noise processing can be automatized to a high degree, and seismic interferometry is very sensitive to small medium changes. Thus there is an opportunity for detection and monitoring of velocity variations in a reservoir at negligible additional cost and effort.Data and results are presented from an ambient noise interferometry study applied to two wells in a producing oil field in Romania. Borehole microseismic monitoring on three component geophones was performed for four weeks, concurrent with a water‐flooding phase for improved oil recovery from a reservoir in ca. 1 km depth. Both low‐frequency (2 Hz–50 Hz) P‐ and S‐waves propagating through the vertical borehole arrays were reconstructed from ambient noise by the virtual source method. The obtained interferograms clearly indicate an origin of the ambient seismic energy from above the arrays, thus suggesting surface activities as sources. It is shown that ambient noise from time periods as short as 30 seconds is sufficient to obtain robust interferograms. Sonic log data confirm that the vertical and horizontal components comprise first arrivals of P‐wave and S‐waves, respectively. The consistency and high quality of the interferograms throughout the entire observation period further indicate that the high‐frequency part (up to 100 Hz) represents the scattered wave field. The temporal variation of apparent velocities based on first‐arrival times partly correlates with the water injection rate and occurrence of microseismic events. It is concluded that borehole ambient noise interferometry in production settings is a potentially useful method for permanent reservoir monitoring due to its high sensitivity and robustness.
Effects of JTV‐519 on stretch‐induced manifestations of mechanoelectric feedback
Authors: del Canto Irene , Such‐Miquel Luis , Brines Laia , Soler Carlos , Zarzoso Manuel , Calvo Conrado , Parra Germán , Tormos Álvaro , Alberola Antonio , Millet José , Such Luis , Chorro Francisco J. 
Published: August 2016

SummaryJTV‐519 is a 1,4‐benzothiazepine derivative with multichannel effects that inhibits Ca2+ release from the sarcoplasmic reticulum and stabilizes the closed state of the ryanodine receptor, preventing myocardial damage and the induction of arrhythmias during Ca2+ overload. Mechanical stretch increases cellular Na+ inflow, activates the reverse mode of the Na+/Ca2+ exchanger, and modifies Ca2+ handling and myocardial electrophysiology, favoring arrhythmogenesis. This study aims to determine whether JTV‐519 modifies the stretch‐induced manifestations of mechanoelectric feedback. The ventricular fibrillation (VF) modifications induced by acute stretch were studied in Langendorff‐perfused rabbit hearts using epicardial multiple electrodes under control conditions (n=9) or during JTV‐519 perfusion: 0.1 μmol/L (n=9) and 1 μmol/L (n=9). Spectral and mapping techniques were used to establish the baseline, stretch and post‐stretch VF characteristics. JTV‐519 slowed baseline VF and decreased activation complexity. These effects were dose‐dependent (baseline VF dominant frequency: control=13.9±2.2 Hz; JTV 0.1 μmol/L=11.1±1.1 Hz, P<.01; JTV 1 μmol/L=6.6±1.1 Hz, P<.0001). The stretch‐induced acceleration of VF (control=38.8%) was significantly reduced by JTV‐519 0.1 μmol/L (19.8%) and abolished by JTV 1 μmol/L (−1.5%). During stretch, the VF activation complexity index was reduced in both JTV‐519 series (control=1.60±0.15; JTV 0.1 μmol/L=1.13±0.3, P<.0001; JTV 1 μmol/L=0.57±0.21, P<.0001), and was independently related to VF dominant frequency (R=.82; P<.0001). The fifth percentile of the VF activation intervals, conduction velocity and wavelength entered the multiple linear regression model using dominant frequency as the dependent variable (R=−.84; P<.0001). In conclusion, JTV‐519 slowed and simplified the baseline VF activation patterns and abolished the stretch‐induced manifestations of mechanoelectric feedback.
What distinguishes cyanobacteria able to revive after desiccation from those that cannot: the genome aspect
Authors: Murik Omer , Oren Nadav , Shotland Yoram , Raanan Hagai , Treves Haim , Kedem Isaac , Keren Nir , Hagemann Martin , Pade Nadin , Kaplan Aaron 
Published: August 2016

SummaryFilamentous cyanobacteria are the main founders and primary producers in biological desert soil crusts (BSCs) and are likely equipped to cope with one of the harshest environmental conditions on earth including daily hydration/dehydration cycles, high irradiance and extreme temperatures. Here, we resolved and report on the genome sequence of Leptolyngbya ohadii, an important constituent of the BSC. Comparative genomics identified a set of genes present in desiccation‐tolerant but not in dehydration‐sensitive cyanobacteria. RT qPCR analyses showed that the transcript abundance of many of them is upregulated during desiccation in L. ohadii. In addition, we identified genes where the orthologs detected in desiccation‐tolerant cyanobacteria differs substantially from that found in desiccation‐sensitive cells. We present two examples, treS and fbpA (encoding trehalose synthase and fructose 1,6‐bisphosphate aldolase respectively) where, in addition to the orthologs present in the desiccation‐sensitive strains, the resistant cyanobacteria also possess genes with different predicted structures. We show that in both cases the two orthologs are transcribed during controlled dehydration of L. ohadii and discuss the genetic basis for the acclimation of cyanobacteria to the desiccation conditions in desert BSC.
Impact of Massachusetts Health Reform on Inpatient Care Use: Was the Safety‐Net Experience Different Than in the Non‐Safety‐Net?
Authors: Hanchate Amresh D. , McCormick Danny , Lasser Karen E. , Feng Chen , Manze Meredith G. , Kressin Nancy R. 
Published: August 2016

ObjectiveMost inpatient care for the uninsured and other vulnerable subpopulations occurs in safety‐net hospitals. As insurance expansion increases the choice of hospitals for the previously uninsured, we examined if Massachusetts health reform was associated with shifts in the volume of inpatient care from safety‐net to non‐safety‐net hospitals overall, or among other vulnerable sociodemographic (racial/ethnic minority, low socioeconomic status, high uninsured rate area) and clinical subpopulations (emergent status, diagnosis).Data Sources/Study SettingDischarge records for adults discharged from all nonfederal acute care hospitals in Massachusetts, New Jersey, New York, and Pennsylvania 2004–2010.Study DesignUsing a difference‐in‐differences design, we compared pre‐/post‐reform changes in safety‐net and non‐safety‐net hospital discharge outcomes in Massachusetts among adults 18–64 with corresponding changes in comparisons states with no reform, overall, and by subpopulations.Principal FindingsReform was not associated with changes in inpatient care use at safety‐net and non‐safety‐net hospitals across all discharges or in most subpopulations examined.ConclusionsDemand for inpatient care at safety‐net hospitals may not decrease following insurance expansion. Whether this is due to other access barriers or patient preference needs to be explored.
Extensive Necrotic Purpura in Levamisole‐Adulterated Cocaine Abuse – A Case Report
Authors: Le Garff Erwan , Tournel Gilles , Becquart Coralie , Cottencin Olivier , Dupin Nicolas , Delaporte Emmanuel , Hedouin Valéry 
Published: August 2016

AbstractLevamisole, which is used as an adulterated compound of cocaine, is currently being seen year after year in cocaine intoxication. For a few cases in the last decade, necrotic purpura and neutropenia after levamisole/cocaine intoxication have been described in the medical community. Herein, we present an original case of levamisole intoxication of a 40‐year‐old woman who smoked heroin and cocaine few during a month. She rapidly presented an extensive necrotic purpura of the nose, cheeks and extremities (lower and upper), and immunologic reactions (positive anti‐MPO and anti‐HNE). Levamisole was detected on hairs with ultra‐high performance liquid chromatography and tandem mass spectrometry. The case reports also a probable cocaine supplier deceit, which bring pure drug for hospital investigation after the intoxication of his client. The intoxicated woman had survived with several skin and chronic pain complications. That case recalls the knowledge about levamisole with a short review of the forensic literature.
Neural Correlates and Connectivity Underlying Stress‐Related Impulse Control Difficulties in Alcoholism
Authors: Seo Dongju , Lacadie Cheryl M. , Sinha Rajita 
Published: August 2016

BackgroundStress triggers impulsive and addictive behaviors, and alcoholism has been frequently associated with increased stress sensitivity and impulse control problems. However, neural correlates underlying the link between alcoholism and impulsivity in the context of stress in patients with alcohol use disorders (AUD) have not been well studied.MethodsThis study investigated neural correlates and connectivity patterns associated with impulse control difficulties in abstinentAUDpatients. Using functional magnetic resonance imaging, brain responses of 37AUDinpatients, and 37 demographically matched healthy controls were examined during brief individualized imagery trials of stress, alcohol cue, and neutral‐relaxing conditions. Stress‐related impulsivity was measured using a subscale score of impulse control problems from Difficulties in Emotion Regulation Scale.ResultsImpulse control difficulties inAUDpatients were significantly associated with hypo‐active response to stress in the ventromedial prefrontal cortex (VmPFC), right caudate, and left lateral PFC (LPFC) compared to the neutral condition (p < 0.01, whole‐brain corrected). These regions were used as seed regions to further examine the connectivity patterns with other brain regions. With the VmPFC seed,AUDpatients showed reduced connectivity with the anterior cingulate cortex compared to controls, which are core regions of emotion regulation, suggestingAUDpatients' decreased ability to modulate emotional response under distressed state. With the right caudate seed, patients showed increased connectivity with the right motor cortex, suggesting increased tendency toward habitually driven behaviors. With the leftLPFCseed, decreased connectivity with the dorsomedialPFC(DmPFC), but increased connectivity with sensory and motor cortices were found inAUDpatients compared to controls (p < 0.05, whole‐brain corrected). Reduced connectivity between the leftLPFCand DmPFCwas further associated with increased stress‐induced anxiety inAUDpatients (p < 0.05, with adjusted Bonferroni correction).ConclusionsHypo‐active response to stress and altered connectivity in key emotion regulatory regions may account for greater stress‐related impulse control problems in alcoholism.
Comparative performance of oral midazolam clearance and plasma 4β‐hydroxycholesterol to explain interindividual variability in tacrolimus clearance
Authors: Vanhove Thomas , de Jonge Hylke , de Loor Henriëtte , Annaert Pieter , Diczfalusy Ulf , Kuypers Dirk R. J. 
Published: August 2016

AimsWe compared the CYP3A4 metrics weight‐corrected midazolam apparent oral clearance (MDZ Cl/F/W) and plasma 4β‐hydroxycholesterol/cholesterol (4β‐OHC/C) as they relate to tacrolimus (TAC) Cl/F/W in renal transplant recipients.MethodsFor a cohort of 147 patients, 8 h area under the curve (AUC) values for TAC and oral MDZ were calculated besides measurement of 4β‐OHC/C. A subgroup of 70 patients additionally underwent intravenous erythromycin breath test (EBT) and were administered the intravenous MDZ probe. All patients were genotyped for common polymorphisms in CYP3A4, CYP3A5 and P450 oxidoreductase, among others.ResultsMDZ Cl/F/W, 4β‐OHC/C/W, EBT and TAC Cl/F/W were all moderately correlated (r = 0.262–0.505). Neither MDZ Cl/F/W nor 4β‐OHC/C/W explained variability in TAC Cl/F/W in CYP3A5 expressors (n = 29). For CYP3A5 non‐expressors (n = 118), factors explaining variability in TAC Cl/F/W in a MDZ‐based model were MDZ Cl/F/W (R2 = 0.201), haematocrit (R2 = 0.139), TAC formulation (R2 = 0.107) and age (R2 = 0.032; total R2 = 0.479). In the 4β‐OHC/C/W‐based model, predictors were 4β‐OHC/C/W (R2 = 0.196), haematocrit (R2 = 0.059) and age (R2 = 0.057; total R2 = 0.312). When genotype information was ignored, predictors of TAC Cl/F/W in the whole cohort were 4β‐OHC/C/W (R2 = 0.167), MDZ Cl/F/W (R2 = 0.045); Tac QD formulation (R2 = 0.036), and haematocrit (R2 = 0.032; total R2 = 0.315). 4β‐OHC/C/W, but not MDZ Cl/F/W, was higher in CYP3A5 expressors because it was higher in CYP3A4*1b carriers, which were almost all CYP3A5 expressors.ConclusionsA MDZ‐based model explained more variability in TAC clearance in CYP3A5 non‐expressors. However, 4β‐OHC/C/W was superior in a model in which no genotype information was available, likely because 4β‐OHC/C/W was influenced by the CYP3A4*1b polymorphism.
Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD‐6972 in healthy subjects and subjects with type 2 diabetes mellitus
Authors: Vajda Eric G. , Logan Douglas , Lasseter Kenneth , Armas Danielle , Plotkin Diane J. , Pipkin JD , Li Yong-Xi , Zhou Rong , Klein David , Wei Xiaoxiong , Dilzer Stacy , Zhi Lin , Marschke Keith B. 
Published: August 2016

AimTo evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of a novel, oral glucagon receptor antagonist, LGD‐6972, in healthy subjects and subjects with type 2 diabetes (T2DM).MethodsIn the single ascending dose study, LGD‐6972 (2‐480 mg) was administered to healthy subjects (n = 48) and T2DM subjects (n = 8). In the multiple ascending dose study, healthy subjects (n = 12) received a dose of 15 mg LGD‐6972 and T2DM subjects (n = 36) received doses of 5, 10 or 15 mg of LGD‐6972 daily for 14 days.Results
LGD‐6972 had linear plasma pharmacokinetics consistent with once‐daily dosing that was comparable in healthy and T2DM subjects. Dose‐dependent decreases in fasting plasma glucose were observed in all groups with a maximum of 3.15 mmol/L (56.8 mg/dL) on day 14 in T2DM subjects. LGD‐6972 also reduced plasma glucose in the postprandial state. Dose‐dependent increases in fasting plasma glucagon were observed, but glucagon levels decreased and insulin levels increased after an oral glucose load in T2DM subjects. LGD‐6972 was well tolerated at the doses tested without dose‐related or clinically meaningful changes in clinical laboratory parameters. No subject experienced hypoglycaemia.ConclusionInhibition of glucagon action by LGD‐6972 was associated with decreases in glucose in both healthy and T2DM subjects, the magnitude of which was sufficient to predict improvement in glycaemic control with longer treatment duration in T2DM patients. The safety and pharmacological profile of LGD‐6972 after 14 days of dosing supports continued clinical development.
Appropriate fabrication method for vacuum‐formed mouthguards
Authors: Mizuhashi Fumi , Koide Kaoru 
Published: August 2016

AbstractAimThe aim was to examine the influence of the heating temperature on the fabrication of vacuum‐formed mouthguards.Materials and methodsMouthguard sheets of 3.8 mm ethylene vinyl acetate were vacuum‐formed on working models at three heating temperatures: 80, 100, and 120°C. The thickness of the mouthguard was measured at the labial surface of the central incisor, and the buccal and occlusal surfaces of the first molar. Differences in the thickness of the mouthguards were analyzed by two‐way analysis of variance. The fit of the mouthguard was examined at the central incisor and the first molar by measuring the distance between the mouthguard and the cervical margin of the working model. Differences in the distance between the mouthguard and the cervical margin according to the heating temperatures were analyzed by one‐way analysis of variance.ResultsMouthguard thickness varied among the measured regions of the central incisors and first molars (P < 0.01). The greatest thickness was found at the labial surface of the central incisor and the buccal surface of the first molar in mouthguards fabricated with heating temperature of 120°C (P < 0.05). The best fit was obtained in mouthguards fabricated with heating temperature of 120°C (P < 0.05).ConclusionsHeating the mouthguard sheet until the temperature reached 120°C was the best fabrication method to maintain the thickness and to obtain proper fit. It is important to control the heating temperature when fabricating vacuum‐formed mouthguards.
Influence of canopy gaps on saproxylic beetles in primeval beech forests: a case study from the Uholka‐Shyrokyi Luh forest, Ukraine
Authors: Lachat Thibault , Chumak Maxim , Chumak Vasyl , Jakoby Oliver , Müller Jörg , Tanadini Matteo , Wermelinger Beat 
Published: August 2016

Abstract

The distribution of canopy gaps has been studied intensively in primeval forest, but their role as keystone structure for biodiversity under natural conditions is still poorly understood.

We investigated the effect of habitat properties on saproxylic beetles in the centre, at the edge of gaps and in closed stands in one of the last and largest primeval beech forest of Europe (Uholka‐Shyrokyi Luh forest, Ukraine).

The abundance of saproxylic beetles was significantly higher in canopy gaps compared to the closed forest. The number of species did not differ significantly between gap centres and closed forest, but was higher in gap centres than at gap edges. Species composition in gap centres was clearly distinct from that in closed forests.

The effects of biotic resources, such as the amount of dead wood or the density of big trees (DBH>70 cm), on diversity measures were weak, which might be caused by the abundance of these resources under natural conditions.

Since our study site is embedded in a landscape dominated by primeval forest, the effects of habitat properties on saproxylic beetle fauna might differ from that in managed forests of Central Europe. Nevertheless, species assemblages in primeval beech forests play an important role as a reference for conservation efforts in managed beech forests of Europe.
Challenges faced by international nurses when migrating: an integrative literature review
Authors: Pung L.‐X. , Goh Y.‐S. 
Published: August 2016

AimResults from this literature review were used to identify the challenges faced by international nurses in their host countries following migration.BackgroundThe increasing strain of nursing shortages in the healthcare system has led to the recruitment of international nurses among many countries. However, following migration, international nurses are faced with challenges that may result in poor integration with their host countries.MethodsUsing Cooper's five stages for integrative research reviews, a literature search was conducted across seven databases using a PRISMA search strategy. Additional manual searches were also conducted on the end‐references of the retrieved articles. The authors then independently reviewed the selected articles using the Joanna Briggs Institute appraisal form to extract and generate the themes for the review.FindingsTwenty‐four articles were selected for the review. The themes generated included: (i) difficulty orientating; (ii) a longing for what is missing; (iii) professional development and devaluing; (iv) communication barriers; (v) discrimination and marginalization; (vi) personal and professional differences; and (vii) a meaningful support system.Implications for policy and practiceBy identifying the challenges faced by international nurses, interventions that ensure equal treatment (e.g. multifaceted transition programmes and culturally sensitive ‘buddy’ systems) can be implemented to help international nurses adapt to their new environments. Adequate communication can be achieved by encouraging international nurses to speak English and learn the colloquial language and non‐verbal behaviours used by native nurses.ConclusionWith good integration international nurses may be able to reach their full career potential as professional nurses in their host countries. The adaptation process is a dynamic process that requires effort from both international and native nurses. Thus, any strategies that are developed and implemented must be multifaceted.