bluuebunny/crossref_metadata_2025_split huggingface dataset:
ROS1 Gene Fusion in Advanced Lung Cancer in Women: A Systematic Analysis, Review of the Literature, and Diagnostic Algorithm
Authors: Marchetti Antonio , Barberis Massimo , Di Lorito Alessia , Pace Maria Vittoria , Di Lisio Chiara , Felicioni Lara , Guerini-Rocco Elena , Vingiani Andrea , D’Antuono Tommaso , Liberatore Marcella , Filice Giampaolo , De Luca Graziano , De Marinis Filippo , Passaro Antonio , Guetti Luigi , Irtelli Luciana , Crinò Lucio , Mucilli Felice , Buttitta Fiamma 
Published: July 2017

Purpose Crizotinib, a mesenchymal-epithelial transition/anaplastic lymphoma kinase/c-ros oncogene 1 (ROS1) inhibitor, has recently been approved by the US Food and Drug Administration for the treatment of patients with advanced ROS1-positive non–small-cell lung cancer (NSCLC). Therefore, interest in ROS1 testing is growing. ROS1 gene fusions affect approximately 0.5% to 2% of unselected NSCLCs. Limited data are available on the prevalence and distribution of ROS1 fusions in patients with advanced-stage NSCLC. Material and Methods A series of 727 lung adenocarcinomas from patients with stage IV disease, negative for epidermal growth factor receptor and anaplastic lymphoma kinase alterations, were tested for ROS1 fusions by fluorescent in situ hybridization analysis, with confirmation by immunohistochemistry. Results were correlated with clinicopathologic parameters and compared with data from the literature. Results ROS1 fusions were detected in 29 patients (4%), including 27 of 266 females (10.2%) and two of 461 males (0.4%; P = 1.2E-10). The mean age of patients with ROS1-positive disease was lower than that of patients with ROS1-negative disease (49.21 v 62.96 years, respectively; P = 1.1E-10). Eleven of 583 smokers (1.9%) and 18 of 144 nonsmokers (12.5%) showed ROS1 rearrangement ( P = 4.05E-7). By logistic regression analysis, ROS1 fusions were independently associated with female sex, younger age at diagnosis, and absence of smoking history, (odds ratios, 12.4, 7.9, and 3.6, respectively). These data, integrated with those reported in the literature, indicate that the prevalence of ROS1 fusions in females and in nonsmokers was higher in patients with advanced disease than in patients with operable disease (11.2% v 3.1%, P < .001; 11.6% v 2.8%, P < .001, respectively). The mean age at diagnosis was significantly lower in patients with advanced disease (49.8 years) than in patients with operable disease (55.6 years; P < .001). Conclusion Our data indicate that ROS1 fusions in patients with advanced-stage lung adenocarcinoma are more frequent in females, particularly if young and nonsmokers. A diagnostic algorithm for an accurate screening of ROS1 alterations was elaborated.
Molecular Testing in Patients With Castration-Resistant Prostate Cancer and Its Impact on Clinical Decision Making
Authors: Tao Derrick L. , Bailey Shawna , Beer Tomasz M. , Foss Erik , Beckett Brooke , Fung Alice , Foster Bryan R. , Guimaraes Alexander , Cetnar Jeremy P. , Graff Julie N. , Eilers Kristine M. , Small Eric J. , Corless Christopher L. , Thomas George V. , Alumkal Joshi J. 
Published: July 2017

Purpose Metastatic castration-resistant prostate cancer (CRPC) is the lethal form of the disease. Many groups have performed mutational or immunohistochemistry (IHC) testing in metastatic CRPC to identify treatment targets. However, the frequency with which mutational or IHC data have an impact on clinical decision making and the outcomes of molecularly guided therapy in CRPC are largely unknown. We report our institution’s experience with mutational and IHC testing in patients with metastatic CRPC and its impact on clinical decision making and patient outcomes. Methods Between 2012 and 2015, 59 patients with CRPC underwent metastatic tissue biopsies and were genotyped with a 37–cancer gene panel in a Clinical Laboratory Improvement Amendments–certified laboratory. PTEN expression by IHC testing was also measured in 35 of these samples. A retrospective chart review was performed to determine whether the genomic information was acted upon and the outcome of patients whose treatment was guided by molecular testing. Results Forty-six of 59 patients with CRPC (78.0%) had biopsies with adequate tumor for mutational testing. Thirty-one of 46 subjects (67.4%) had mutations identified by sequencing. Of the 35 patients with CRPC whose biopsies were evaluated for PTEN expression by IHC testing, 13 had PTEN loss. Two patients had treatment on the basis of molecular testing, and one of these subjects had greater tumor control with molecularly guided therapy than his immediate prior therapy. Conclusion Targeted sequencing and IHC can identify clinically informative molecular abnormalities in CRPC. Despite this, a small minority of patients in our series underwent therapies guided by mutational or IHC testing. Actionability of abnormalities identified in metastatic CRPC may be improved with access to clinical trials, insurance approval for unapproved uses of existing anticancer drugs, and larger gene sequencing panels that include more frequently mutated genes.
Presidential Address: Memory and Mobility: Grandma’s Mahnomen, White Earth
Authors: O’Brien Jean M. 
Published: July 2017

Abstract
In Jean M. O’Brien’s 2013 American Society for Ethnohistory Presidential Address, “Memory and Mobility: Grandma’s Mahnomen, White Earth,” she uses reminiscences of her grandmother, Edna Wright Tonneson, to explore the coming of her family to the White Earth Ojibwe Reservation in northwestern Minnesota in the late nineteenth century. Like many others from White Earth, her family’s story of reservation life involved ongoing patterns of mobility that predated and postdated their life on White Earth. While allotment policy drew them to the reservation, subsequent dispossession spurred further mobility but did not displace their identity as White Earth Ojibwes.
Chelsea, Pimlico and Belgravia District Nursing Association 1930–1939: A case study
Authors: Bliss Julie 
Published: July 2017

The case study explores how the expansion of the health services during the interwar period impacted upon the status of district nursing and examines how being a voluntary service shaped district nursing associations. A range of primary sources were used; the Association Annual Reports, the Medical Officer for Health Annual Reports for the Borough of Chelsea, the Ministry of Health records, the archives of the Queen's Nursing Institute (QNI) and the Borough of Chelsea Council Minutes. The Medical Officer for Health Reports and the Council minutes identify efforts to improve environmental factors that impacted upon health. These primary sources briefly note the contribution of the Association suggesting that it was integral to the health care provision but considered a constant. The impact of changes to the 1932 Sunday Entertainments Act provide an interesting juxtaposition between the acknowledged value of district nursing and the constant struggle to fundraise in order to provide home nursing. Throughout the 1930s the Association experienced staff shortages and challenges regarding recruitment. The complexities of payment for municipal health services following the 1929 Local Government Act contributed to the staffing challenges. The move to a block grant in 1938 provided increased stability with regards to income. The case study identifies a contradiction regarding the esteem and value placed upon district nursing associations providing home nursing and the constant challenge of resources. District nursing services face similar challenges and this is the 130th anniversary of the Queen's Nursing Institute.
Fathers and breastfeeding: Attitudes, involvement and support
Authors: Al Namir Hibah Maki A , Brady Anne-Marie , Gallagher Louise 
Published: July 2017

Background Fathers are recognised as a major source of social support for breastfeeding mothers. Mothers repeatedly identify their infant's father as an important part of the decision to breastfeed, yet limited research has focused on fathers and breastfeeding. Aims To review existing literature on the attitudes of fathers towards breastfeeding and their involvement in supporting mothers. Methods Studies were initially grouped according to research design, then each appraised against quality standards for respective designs. The selected studies were then re-grouped under themes and a narrative synthesising approach to findings was undertaken to develop the discussion. Data sources included a library and electronic search, conducted between January 2014 and June 2015, of the literature published between 1992 and 2015. Findings Fathers' positive attitude, involvement and support greatly influenced breastfeeding decision and commitment among mothers and was associated with increased breastfeeding rates and duration. The exclusion of fathers from breastfeeding support and preparation may result in decreased quality of life and self-efficacy among fathers. There is, however, a lack of clear evidence regarding what exactly constitutes the nature of fathers' support. Conclusions Taken collectively, the review findings demonstrate that focusing on fathers as a major part of the breastfeeding family and engaging them in the preparation and support process would certainly impact positively on breastfeeding rates.
Students' experience of the use of an online learning channel in teaching and learning: A sports therapy perspective
Authors: Wilson Lynsey , Greig Matt 
Published: July 2017

Background/Aims: The inclusion of blended e-learning approaches to teaching has become more prevalent in higher education. The purpose of this paper was to examine sports therapy students' experiences of using an online learning channel designed to assist practical skills. Moreover, creating an understanding of students' adoption of the learning channel to determine its efficacy. Methods: The design was a qualitative exploratory study in which a questionnaire was designed to investigate students' experience of using the learning channel across all undergraduate BSc Sports Therapy modules. One-hundred and sixty-four (level four: n=67; level five: n=51; level six: n=46) students completed the questionnaire relating to their experience of an online video-based learning channel. Findings: BSc Sports Therapy students across all levels found the learning channel useful, with the most common responses related to revision and consolidation of practical skills. Exam preparation was associated to this suggesting students' beliefs were driven by resources which could facilitate grade improvement in practical exams. Conclusions: The sports therapy learning channel was received very positively, with both the visual and practical nature of online instructional videos deemed important.
PUBLIC AWARENESS ON HARMFUL ALGAL BLOOM (HAB) IN LAMPUNG BAY
Authors: Aditya Vishnu , Koswara Asep , Fitriya Nurul , Rachman Arief , Sidabutar Tumpak , Thoha Hikmah 
Published: July 2017

Harmful algal blooms (HABs) cause various problems, such as water quality degradation, fauna mass mortality and impairment of human health. Water quality monitoring in Lampung Bay has been conducted by Lampung Marine Aquaculture Office (BBL) of the Ministry of Marine Affairs and Fisheries since 1994. Occurrence of Pyrodinium bahamense var. compressum (Pbc), a causative organism of paralytic shellfish poisoning (PSP), has been recorded but threats caused by HABs have never been reported. A study aimed to know the level of public knowledge and awareness about HABs in Lampung Bay has been conducted. The components of group respondents consisted oflocal governments, academics and coastal communities. Awareness from each component was examined includinggeneral HAB knowledge, HAB impact to the community, HAB occurence and local knowledge of HAB. Data of HAB knowledge were collected through questionnaire and focus groupÂ discussion. The result showed that 40.5% of respondents had knowledge of HABs phenomena and 51.3% respondents only know signs or indicators of HAB occurrence, while only 1.4% respondents had knowledge of local HAB occurences. The direct impact of HABs to the community was not commonly known by the respondents. Only a few cases of poisoning after eating seafood were reported. It can be concluded that there was lack of public knowledge and awareness on HABs in LampungBay. Intensive public awareness programs about HABs should be conducted in order to reduce risk towards HABs in Lampung Bay.
Creating a low carbon tourism community by public cognition, intention and behaviour change analysisa case study of a heritage site (Tianshan Tianchi, China)
Authors: Wu Wenjie , Zhang Xiaolei , Yang Zhaoping , Wall Geoffrey , Wang Fang 
Published: July 2017

AbstractThis study attempts to explore the establishment of a low-carbon tourism community by public cognition, intention, and behaviour change analysis in a case study of a heritage site, China. Low carbon tourism advocates a way of travel with low energy consumption, low pollution and low CO
Spatial uncertainty of a geoid undulation model in Guayaquil, Ecuador
Authors: Chicaiza E.G. , Leiva C.A. , Arranz J.J. , Buenańo X.E. 
Published: July 2017

AbstractGeostatistics is a discipline that deals with the statistical analysis of regionalized variables. In this case study, geostatistics is used to estimate geoid undulation in the rural area of Guayaquil town in Ecuador. The geostatistical approach was chosen because the estimation error of prediction map is getting. Open source statistical software R and mainly geoR, gstat and RGeostats libraries were used. Exploratory data analysis (EDA), trend and structural analysis were carried out. An automatic model fitting by Iterative Least Squares and other fitting procedures were employed to fit the variogram. Finally, Kriging using gravity anomaly of Bouguer as external drift and Universal Kriging were used to get a detailed map of geoid undulation. The estimation uncertainty was reached in the interval [-0.5; +0.5] m for errors and a maximum estimation standard deviation of 2 mm in relation with the method of interpolation applied. The error distribution of the geoid undulation map obtained in this study provides a better result than Earth gravitational models publicly available for the study area according the comparison with independent validation points. The main goal of this paper is to confirm the feasibility to use geoid undulations from Global Navigation Satellite Systems and leveling field measurements and geostatistical techniques methods in order to use them in high-accuracy engineering projects.
Prediction of Primary Tumors in Cancers of Unknown Primary
Authors: Søndergaard Dan , Nielsen Svend , Pedersen Christian N.S. , Besenbacher Søren 
Published: July 2017

AbstractA cancer of unknown primary (CUP) is a metastatic cancer for which standard diagnostic tests fail to identify the location of the primary tumor. CUPs account for 3–5% of cancer cases. Using molecular data to determine the location of the primary tumor in such cases can help doctors make the right treatment choice and thus improve the clinical outcome. In this paper, we present a new method for predicting the location of the primary tumor using gene expression data: locating cancers of unknown primary (LoCUP). The method models the data as a mixture of normal and tumor cells and thus allows correct classification even in impure samples, where the tumor biopsy is contaminated by a large fraction of normal cells. We find that our method provides a significant increase in classification accuracy (95.8% over 90.8%) on simulated low-purity metastatic samples and shows potential on a small dataset of real metastasis samples with known origin.
Deposing deponency: Latin non-denominal deponents are not grammatically idiosyncratic verbs
Authors: Pinzin Francesco 
Published: July 2017

AbstractLatin deponents are usually treated as morphological idiosyncrasies in which the Middle morphology is not related to an anticausative (change of state), reflexive or passive syntactic structure, in which it would be expected and grammatically justified (Embick, David. 2000. Features syntax and categories in the Latin perfect.
Causal neuro-immune relationships at patients with chronic pyelonephritis and cholecystitis. Correlations between parameters EEG, HRV and white blood cell count
Authors: Kul’chyns’kyi Andriy B , Kyjenko Valeriy M , Zukow Walery , Popovych Igor L 
Published: July 2017

AbstractWe aim to analyze in bounds KJ Tracey’s immunological homunculus conception the relationships between parameters of electroencephalogram (EEG) and heart rate variability (HRV), on the one hand, and the parameters of bhite blood cell count, on the other hand.MethodsIn basal conditions in 23 men, patients with chronic pyelonephritis and cholecystitis in remission, recorded EEG (“NeuroCom Standard”, KhAI Medica, Ukraine) and HRV (“Cardiolab+VSR”, KhAI Medica, Ukraine). In portion of blood counted up white blood cell count.ResultsRevealed that canonical correlation between constellation EEG and HRV parameters form with blood level of leukocytes 0.92 (p<10-5), with relative content in white blood cell count stubnuclear neutrophiles 0.93 (p<10-5), segmentonucleary neutrophiles 0.89 (p<10-3), eosinophiles 0.87 (p=0.003), lymphocytes 0.77 (p<10-3) and with monocytes 0.75 (p=0.003).ConclusionParameters of white blood cell count significantly modulated by electrical activity some structures of central and autonomic nervous systems.
Measuring efficiency of secondary healthcare providers in Slovenia
Authors: Blatnik Patricia , Bojnec Štefan , Tušak Matej 
Published: July 2017

AbstractThe chief aim of this study was to analyze secondary healthcare providers' efficiency, focusing on the efficiency analysis of Slovene general hospitals. We intended to present a complete picture of technical, allocative, and cost or economic efficiency of general hospitals.MethodsWe researched the aspects of efficiency with two econometric methods. First, we calculated the necessary quotients of efficiency with the stochastic frontier analyze (SFA), which are realized by econometric evaluation of stochastic frontier functions; then, with the data envelopment analyze (DEA), we calculated the necessary quotients that are based on the linear programming method.ResultsResults on measures of efficiency showed that the two chosen methods produced two different conclusions. The SFA method concluded Celje General Hospital is the most efficient general hospital, whereas the DEA method concluded Brežice General Hospital was the hospital to be declared as the most efficient hospital.ConclusionOur results are a useful tool that can aid managers, payers, and designers of healthcare policy to better understand how general hospitals operate. The participants can accordingly decide with less difficulty on any further business operations of general hospitals, having the best practices of general hospitals at their disposal.
Performance of a transfer beam with hybrid reinforcement of CFRP bars and steel bars under reversed cyclic loading
Authors: Chen Jin , Jiang Shiyong , Zeng Xiangrong , Zhou Ling , Sun Tao , Yao Kai , Zhang Lei 
Published: July 2017

AbstractHybrid carbon fiber reinforced plastic (CFRP) and steel bar reinforcement concrete were applied in a transfer beam. Three specimens (ZHL-2, ZHL-3, and ZHL-4) corresponded to different forms of reinforcement, reinforcement ratio, and reinforced root number, respectively. The pseudo static test of the three specimens was carried out under the condition of vertical loading and horizontal reversed cyclic loading. The flexural property and failure mode of the transfer beams were demonstrated. Further, the ductility, energy dissipation capability, hysteretic characteristics, structural yield mechanism, and failure mechanism were also studied. The exploration of these factors was aimed to study the bearing capacity and seismic performance of the transfer beam with hybrid CFRP and steel bars. The test results show that if both the upper and lower longitudinal reinforcements were replaced by CFRP bars with a symmetrical reinforcement, the mechanical property and deformation performance would be superior. The performance would be better than the reinforcements with single upper and lower replacement by CFRP bars. Both the upper and lower longitudinal bars of the transfer beam should be replaced by CFRP bars with a symmetrical form of reinforcement. The ductility performance would be better for the transfer beam with the hybrid reinforcement of CFRP bars and steel bars. It showed a seismic performance. The transfer beam with the hybrid reinforcement of CFRP bars and steel bars could meet the design requirements for the ductile frame “strong column, weak beam and strong node.”
Surface modification of polyimide fibers by oxygen plasma treatment and interfacial adhesion behavior of a polyimide fiber/epoxy composite
Authors: Sun Xuyang , Bu Junfeng , Liu Weiwei , Niu Hongqing , Qi Shengli , Tian Guofeng , Wu Dezhen 
Published: July 2017

AbstractOxygen plasma was used to enhance the surface behavior of polyimide (PI) fibers and PI fiber-reinforced epoxy composites were prepared in our present work. The effects of plasma treating times on the surface properties of PI fiber and the interfacial adhesion of PI fiber/epoxy composites were investigated. Surface chemical composition, surface morphologies and surface free energy of the fibers were characterized by X-ray photoelectron spectroscopy, scanning electron microscopy and dynamic contact angle analysis, respectively. The results suggest that some oxygen functional groups were introduced onto PI fiber surfaces, and the surface roughness of fibers was enhanced. Resultantly, the surface free energy of fibers and the interfacial adhesion of composites were improved by the oxygen plasma treatment. The interlaminar shear strength of the composites increased to 70 MPa when the fibers were treated for 10 min, which proved good interfacial adhesion properties.
Design and Numerical Investigations on a Dual-Duct Variable Geometry RBCC Inlet
Authors: Liu Xiaowei , Shil Lei , Liu Peijin , Qin Fei , He Guoqiang 
Published: July 2017

Abstract
A widely applicable and variable geometry 2-D rocket based combined cycle (RBCC) inlet characterized by the dual-duct design is conceptually put forward. The inlet operates as dual-duct status in the low Mach range (0~4), and transits to single-flowpath status in the following high Mach range (4~7). It accomplishes operational status transition through an 8.0-degree ramp rotation and a 4.0-degree cowl rotation at Mach 4. Through numerical simulations on typical flight Mach numbers, the observed starting Mach number is 2.2, which provides a sufficient operational window for a smooth ejector-to-ramjet mode transition. The RBCC inlet achieves comprehensive high mass capture coefficients in the overall wide flight range, especially in the low speed regimes. Suitable Mach numbers satisfying various combustion requirements in different modes together with high total pressure recovery coefficients are also obtained since the physical throat areas, compression angles, and the corresponding contraction ratios can be adjusted by a large margin through very limited rotations. The variable geometry scheme is not only feasible for practical realizations, but is also simple to arrange the dynamic sealing issues in a low-temperature environment in the RBCC engine.
The Close-Grip Bench Press
Authors: Lockie Robert G. , Moreno Matthew R. 
Published: July 2017

ABSTRACT
THE CLOSE-GRIP BENCH PRESS HAS RECEIVED LIMITED ANALYSIS IN THE PROFESSIONAL LITERATURE. THEREFORE, THIS ARTICLE WILL REVIEW THE EXISTING LITERATURE THAT DOCUMENTS THE TECHNIQUE, MUSCLE ACTIVATION CHANGES THAT OCCUR WHEN PERFORMING THIS EXERCISE, AND THE RESULTING IMPLICATIONS. THIS RELATES TO POTENTIAL HYPERTROPHY AND STRENGTH ADAPTATIONS THAT MAY RESULT FOR MUSCLES INVOLVED IN ELBOW EXTENSION (E.G., TRICEPS BRACHII) AND ARM FLEXION (E.G., PECTORALIS MAJOR), AS WELL AS SPORT-SPECIFIC POWER ADAPTATIONS. THE BENEFITS OF USING A CLOSER GRIP DURING THE BENCH PRESS FOR CERTAIN INDIVIDUALS WILL BE ACKNOWLEDGED. LAST, THE EXECUTION OF THIS EXERCISE (STARTING POSITION, BAR DESCENT, AND BAR ASCENT) WILL BE DETAILED.