bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of laryngopharyngeal reflux on subjective and objective voice assessments: A prospective study
Authors: Lechien Jérôme R. , Huet Kathy , Khalife Mohamad , Fourneau Anne-Françoise , Delvaux Véronique , Piccaluga Myriam , Harmegnies Bernard , Saussez Sven 
Published: November 2016

Background Laryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the subjective and objective voice modifications in Laryngopharyngeal reflux (LPR), especially the usefulness of acoustic parameters as treatment outcomes, and to better understand the pathophysiological mechanisms underlying the development of voice disorder. Methods Forty-one patients with a reflux finding score (RFS) > 7 and a reflux symptom index (RSI) > 13 were enrolled and treated with pantoprazole 20 mg twice daily for three months. RSI, RFS, Voice Handicap Index (VHI), and Grade, Roughness, Breathiness, Asthenia, Strain and Instability (GRBASI) were assessed at baseline and after three months post-therapy. Acoustic parameters were measured by selecting the most stable interval of the vowel /a/. A study of correlations between acoustic measurements and laryngoscopic signs was conducted in patients with roughness. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS). Results Significant improvement in RSI, RFS, VHI, jitter, percent jitter, relative average perturbation (RAP), shimmer, percent shimmer, and amplitude perturbation quotient (APQ) was found at 3 months of treatment ( p < .05). A correlation analysis revealed significant correlations between the grade of dysphonia, breathiness, asthenia, instability and jitter, percent jitter, RAP, shimmer, percent shimmer and APQ. In dividing our cohort into two groups of patients according to the presence of roughness, shimmer, percent shimmer and APQ significantly improved in patients with roughness, but no positive correlation was found between acoustic parameters and laryngoscopic signs. Conclusion Acoustic parameters can help to better understand voice disorders in LPR and can be used as treatment outcomes in patients with roughness.
Novel Epigenetic Biomarkers Mediating Bisphenol A Exposure and Metabolic Phenotypes in Female Mice
Authors: Anderson Olivia S. , Kim Jung H. , Peterson Karen E. , Sanchez Brisa N. , Sant Karilyn E. , Sartor Maureen A. , Weinhouse Caren , Dolinoy Dana C. 
Published: November 2016

Abstract
There is compelling evidence that epigenetic modifications link developmental environmental insults to adult disease susceptibility. Animal studies have associated perinatal bisphenol A (BPA) exposure to altered DNA methylation, but these studies are often limited to candidate gene and global non–loci-specific approaches. By using an epigenome-wide discovery platform, we elucidated epigenetic alterations in liver tissue from adult mice offspring (10 months) following perinatal BPA exposure at human physiologically relevant doses (50-ng, 50-μg, and 50-mg BPA/kg diet). Biological pathway analysis identified an enrichment of significant differentially methylated regions in metabolic pathways among females. Furthermore, through the use of top enriched biological pathways, 4 candidate genes were chosen to assess DNA methylation as a mediating factor linking the association of perinatal BPA exposure to metabolic phenotypes previously observed in female offspring. DNA methylation status at Janus kinase-2 (Jak-2), retinoid X receptor (Rxr), regulatory factor x-associated protein (Rfxap), and transmembrane protein 238 (Tmem238) was used within a mediational regression analysis. DNA methylation in all four of the candidate genes was identified as a mediator in the mechanistic pathway of developmental BPA exposure and female-specific energy expenditure, body weight, and body fat phenotypes. Data generated from this study are crucial for deciphering the mechanistic role of epigenetics in the pathogenesis of chronic disease and the development of epigenetic-based prevention and therapeutic strategies for complex human disease.
An Analysis and Visualization Methodology for Identifying and Testing Market Structure
Authors: France Stephen L. , Ghose Sanjoy 
Published: November 2016

We introduce a method for identifying, analyzing, and visualizing submarkets in product categories. We give an overview of the market structure and competitive submarket literature and then describe a classic model for testing competitive submarkets along with associated extensions. In the era of big data and with the increasing availability of large-scale consumer purchase data, there is a need for techniques that can interpret these data and use them to help make managerial decisions. We introduce a statistical likelihood based technique for both identifying and testing market structure. We run a series of experiments on generated data and show that our method is better at identifying market structure from brand substitution data than a range of methods described in the marketing literature. We introduce tools for holdout validation, complexity control, and testing managerial hypotheses. We describe a method for visualization of submarket solutions, and we give several traditional consumer product examples and in addition give an example to show how market structure can be analyzed from online review data. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mksc.2015.0958 .
ETHICS IN CLINICAL RESEARCH: IS ETHICS INVOLVED INTO THE PHARMACY STUDIES IN EUROPE?
Authors: Žufková Viera , Klimas Ján , Kyselovič Ján , Vivoda Michal , Šuráb Marián 
Published: November 2016

One of the key questions in medicine nowadays is the ethics and its maximum involvement into medical profession. The absence of ethics is very notable in public and professional relations. In spite of the fact that the pharmacy profession was separated from the medical profession in the 13th century by the emperor Frederic II, the ethics is involved into pharmacy study in minimum amount. In the article there is presented the ethics inclusion into pharmacy study in 31 Universities of the European Union (EU). The method of our research was the analysis of 31 WebPages of Faculties of Pharmacy in the EU. The ethics is taught in the 45% study programmes. It is mostly a part of syllabus of master programme (Czech Republic, Estonia and Portugal) or bachelor programme (Slovakia). We have not managed to find a full study plan in 13% of study plans. As the ethics remains the crucial part of the pharmacy profession, there is a great importance of its involvement into the pharmacy study. The Code of Conduct for Pharmacy students with its seven principles shall be a part of ethical preparation of future pharmacists in Europe.
A numerical study on slip flow in packed hyper-porous media inside micro-channels using differential transformation method
Authors: Saffari Puyan , Fatahian Esmaeel , Saffari Peyman , Fatahian Hossein 
Published: November 2016

Velocity slip boundary condition in parallel-plate micro-channels filled with hyper-porous media is studied using differential transformation method (DTM) in order to find an analytical approximate solution. The results focus on slip flow regime (i.e., for Knudsen numbers in the range 10−3 < Kn < 10−1). The Darcy-Brinkman-Forchheimer model is applied to study the effect of nonlinear drag term further boundary-friction effects on hydrodynamic of gas flow in micro-channels. The results show that DTM results are in good agreement with numerical ones. Also, it is observed that decreasing the value of Darcy number flattens the velocity profile while this trend is opposite for decreasing the Forchheimer number. Also, increasing the value of causes to increase the velocity slip at the wall.
Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses ofmRNAfrom adipose tissue and whole body magnetic resonance imaging
Authors: Lee Sindre , Norheim Frode , Langleite Torgrim M. , Noreng Hans J. , Storås Trygve H. , Afman Lydia A. , Frost Gary , Bell Jimmy D. , Thomas E. Louise , Kolnes Kristoffer J. , Tangen Daniel S. , Stadheim Hans K. , Gilfillan Gregor D. , Gulseth Hanne L. , Birkeland Kåre I. , Jensen Jørgen , Drevon Christian A. , Holen Torgeir ,   the NutriTech Consortium
Published: November 2016

AbstractOverweight and obesity lead to changes in adipose tissue such as inflammation and reduced insulin sensitivity. The aim of this study was to assess how altered energy balance by reduced food intake or enhanced physical activity affect these processes. We studied sedentary subjects with overweight/obesity in two intervention studies, each lasting 12 weeks affecting energy balance either by energy restriction (~20% reduced intake of energy from food) in one group, or by enhanced energy expenditure due to physical exercise (combined endurance‐ and strength‐training) in the other group. We monitoredmRNAexpression by microarray andmRNAsequencing from adipose tissue biopsies. We also measured several plasma parameters as well as fat distribution with magnetic resonance imaging and spectroscopy. Comparison of microarray andmRNAsequencing showed strong correlations, which were also confirmed usingRT‐PCR. In the energy restricted subjects (body weight reduced by 5% during a 12 weeks intervention), there were clear signs of enhanced lipolysis as monitored bymRNAin adipose tissue as well as plasma concentration of free‐fatty acids. This increase was strongly related to increased expression of markers for M1‐like macrophages in adipose tissue. In the exercising subjects (glucose infusion rate increased by 29% during a 12‐week intervention), there was a marked reduction in the expression of markers of M2‐like macrophages and T cells, suggesting that physical exercise was especially important for reducing inflammation in adipose tissue with insignificant reduction in total body weight. Our data indicate that energy restriction and physical exercise affect energy‐related pathways as well as inflammatory processes in different ways, probably related to macrophages in adipose tissue.
Morphological Variation and Speciation of Acavidae Family: A Case Study from Fossil and Living Species of Batadombalena Cave Pre-historic Site in Sri Lanka
Authors: Sumanarathna Aravinda Ravibhanu , Madurapperuma Buddhika , Kuruppuarachchi Janaka , Katupotha Jinadasa , Abeywardhana S.M.K. , Jayasinghe Pathmakumara 
Published: November 2016

Abstract
A sufficient knowledge on prehistoric culture and habitat of earliest Homo sapiens (Balangoda man) is available in Batadomba-lena cave, a noticeable rock shelter in lowland rainforest of southwestern Sri Lanka goes upto Pleistocene and Holocene eras. Late Pleistocene inhabitants of Batadombalena cave’s foraged for a broad spectrum of plant and mainly arboreal animal resources such as, monkeys, squirrels and rainforest snails etc. Archaeo-faunal evidence would help to describe the prehistoric man eating behavior as well as availability of nature pre-historic flora, fauna and environmental status. The family Acavidae is very sensitive to climatic variations, hence used as a bio-indicator to describe the variations of paleo-climatic nature. This study examined the morphological features of 20 samples of Acavidae family (living/fossil samples of Acavus superbus, and sub fossil samples of Oligospira waltoni) collected from soils by digger method in 2005 and compared with 20 samples from the same area at presently available. The shell characters of snails such as, height, width, diameter of mouth, thickness of lip, and angular of axis were measured and subjected to multivariate analysis to understand how climatic variability and nature of paleo-diet contribute survival of Acavidae species. Results showed that Acavus superbus living species had large shell characteristics than the sub fossils. Results of similar study in the same climatic status in 2000 showed that the shell measurements of Acavus superbus are relatively larger than both living and sub fossils in Batadobalena cave. Ordination diagram derived from species shell characteristics showed that Acavus superbus living species grouped as scattered /diffuse clusters, while sub fossil species grouped as a single cluster at the center of the ordination diagram. It is imply a trend of speciation /diversification of Acavus species from Pleistocene era to date. Multivariate analyses prove that, a strong positive correlation of species characteristics, such as height (r = 0.62), thickness of lip (r = 0.544) and angular of axis (r = 0.744), and a strong negative relationship (r = 0.832) for shell width for the species were observed. Our results are useful to compare with other fossil snails to see whether the climate change influence for changing body size. In conclusion, palaeo-environment, and present environment variation has been occurred in minimum way without much changes to observed Acavidae species compositions present and past.
Economic Impact of Accommodation Structures on the Local Territorial System
Authors: Barbu Constantin Ionuţ , Stănilă Andreea 
Published: November 2016

Abstract
The tourists servicing structure or unit in a particular territory has an impact on it as a result of the links which it (accommodation) establishes with certain environments, in which it evolves and which are connected to one other, leading in the end to the organization of space and hence the impact of tourism on the territory where accommodation options were implemented. In the whole local economy, tourism acts as a stimulating element of the local economic system, assuming a specific request for goods and services, which also causes an increase in their production sphere. Also, the touristic demand determines a correlated supply, which is materialized in the development of touristic structures and indirectly participating in the stimulating of production branches: construction and development of new means of transport, leisure facilities for winter sports, water sports, etc. Tourism development thus leads to a significant increase of production. Tourism drives and stimulates production in other areas. Tourism is a way of diversifying the economic structure of a country, region, territory. Tourism is capable of ensuring the prosperity of disadvantaged areas, being a cure for unindustrialized regions. This can be achieved through the development of less resource-rich areas with high economic value, which have a great heritage of natural and anthropogenic tourist resources. As a result, tourism is considered a lever to mitigate inter-regional imbalances. Furthermore, tourism, because it is a major consumer of force, plays an important role in the economy. It creates new jobs, thus participating in attracting extra labor from other sectors, helping to alleviate unemployment. It is important to note the fact that a job exclusively in tourism can generate 3 other indirect or induced related jobs. This can be explained by the fact that tourism is a major consumer of goods and services positively influencing labor use in its branches (agriculture, food processing, construction, transport, etc.).
On Mystical Metamorphosis in Christianity and Islam: Dante’s Divine Comedy and Rumi’s Masnavi in Comparative Perspective
Authors: Seblini Nour 
Published: November 2016

Abstract
Journey emerges in multiple faces in literature. But when this substantial subset of quests adopts the mystical aspect, it creates a mystery that triggers the discovery sense in human beings. The present article develops a comparative analysis on the complex nature of mystical metamorphosis as expressed in two of the most influential writings of the East and West: Rumi’s Masnavi and Dante’s Divine Comedy. The first part discusses the concept of mysticism and poetry, and reveals the nature of their connection. The second part of this work investigates the historical setting of Dante’s and Rumi’s lives in relation to the social environment of the time. The last part emphasizes the idea of mystical metamorphosis as expressed in the Divine Comedy and Masnavi through two fundamental vehicles: love and faith. This work demonstrates how, in a world rife with wars and misery, mysticism provides a vital key to building a strong bridge between Islam and Christianity, and on a larger scale, to metamorphosizing the “clash of civilizations” into a “confluence of civilizations”.
Are Orthotrichum and Dorcadion (Orthotrichaceae, Bryophyta) heterotypic generic names?
Authors: Plášek Vítězslav , Sawicki Jakub , Ochyra Ryszard 
Published: November 2016

AbstractThe generic name Dorcadion Adans. ex Lindb. is a superfluous and illegitimate name for Orthotrichum Hedw. The new generic name Dorcadionella Plášek, Sawicki & Ochyra is proposed for a segregate of Orthotrichum which comprises species with superficial stomata that are always monoicous and only occasionally produce gemmae on leaves. Dorcadionella affinis (Schrad. ex Brid.) Plášek, Sawicki & Ochyra is selected as a type of this new generic name. The genus Dorcadionella consists of 63 species and one variety that have a worldwide distribution. Traditionally, they were all placed in Orthotrichum and the relevant transfers to the new genus are effected in the present account.
The insect-derived antimicrobial peptide metchnikowin targets Fusarium graminearum β(1,3)glucanosyltransferase Gel1, which is required for the maintenance of cell wall integrity
Authors: Bolouri Moghaddam Mohammad-Reza , Vilcinskas Andreas , Rahnamaeian Mohammad 
Published: November 2016

Abstract
Antimicrobial peptides (AMPs) are essential components of the insect innate immune system. Their diversity provides protection against a broad spectrum of microbes and they have several distinct modes of action. Insect-derived AMPs are currently being developed for both medical and agricultural applications, and their expression in transgenic crops confers resistance against numerous plant pathogens. The antifungal peptide metchnikowin (Mtk), which was originally discovered in the fruit fly Drosophila melanogaster, is of particular interest because it has potent activity against economically important phytopathogenic fungi of the phylum Ascomycota, such as Fusarium graminearum, but it does not harm beneficial fungi such as the mycorrhizal basidiomycete Piriformospora indica. To investigate the specificity of Mtk, we used the peptide to screen a F. graminearum yeast two-hybrid library. This revealed that Mtk interacts with the fungal enzyme β(1,3)-glucanosyltransferase Gel1 (FgBGT), which is one of the enzymes responsible for fungal cell wall synthesis. The interaction was independently confirmed in a second interaction screen using mammalian cells. FgBGT is required for the viability of filamentous fungi by maintaining cell wall integrity. Our study therefore paves the way for further applications of Mtk in formulation of bio fungicides or as a supplement in food preservation.
Prevalence and Characteristics of Surgical Site Infections Caused by Gram-negative Rod-shaped Bacteria from the Family Enterobacteriacae and Gram-positive Cocci from the Genus Staphylococcus in Patients who Underwent Surgical Procedures on Selected Surgical Wards
Authors: Tomaszewska-Kowalska Małgorzata , Kołomecki Krzysztof , Wieloch-Torzecka Maria 
Published: November 2016

AbstractSurgical site infections on surgical wards are the most common cause of postoperative complications. Prevalence of surgical site infections depends on the surgical specialization. Analysis of the causes of surgical site infections allows to conclude that microorganisms from the patient’s own microbiota – Gram-negative rod-shaped bacteria from the family Enterobacteriacae and from the patient’s skin microbiota – Gram-positive cocci – Staphylococcus are the most common agents inducing surgical site infections.was to assess prevalence and characteristics of surgical site infections caused by Gram-negative rod-shaped bacteria from the family Eneterobacteriacae and Gram-positive cocci from the genus Staphylococcus in patients who underwent surgical procedures at the Regional Specialist Hospital named after M. Copernika in Łódź on selected surgical wards.The study was performed based on retrospective analysis of medical documentation of the treated patients. The study included 195 patients of the Regional Specialist Hospital named after M. Copernik in Łódź who were treated between 2012 and 2014 on the wards of: Vascular, General and Oncological Surgery, Trauma and Orthopaedic Surgery, Neosurgery and Nervous System Tumors and the Ward of Endocrine Surgery – in the Clinic of Endocrine Surgery. The study included 84 women and 111 men. Mean age was 59 years (18 – 94 years old). \Surgical site infections caused by Gram-negative rod-shaped bacteria from the family Enterobacteriacae were reported in 84 out of 195 patients (43.08% of the study group) and by Gram-positive cocci from the genus Staphylococcus were reported in 52 patients (26.67% of the study group). Mixed microbiota was an etiological agent of surgical site infections in four patients (2.5% of the study group).Etiological agent of surgical site infections depends on the ward profile, surgical field cleanliness and a form of surgical site infection.
Pulmonary Artery Perforation as a Complication of Pleural Drainage – Case Report
Authors: Gołota Janusz Jacek , Kiliańczyk Michał , Szmyt Piotr 
Published: November 2016

AbstractThe case presented is a drainage of empyema of the left pleural cavity complicated with the penetration of the lung parenchyma and perforation of the left pulmonary artery with drain displacement to the right pulmonary artery. The cause of complications has been shown along with the possible ways of conduct. Drainage of the pleural cavity is a primary surgery in the chest. The presence of pleural air or fluid is an indication for its implementation. This procedure usually has no complications. Time pressure, anatomical anomalies, changes of the topography in the course of co-morbidities are the factors allowing for the creation of many complications.The aim of the work is to remind about the technical performance of this simple surgical procedure and to note that its complications may directly threaten the life of the patient. This is the first case reported in Polish literature.
Coaxial Linear Motor for Electromagnetic Launchers
Authors: Grigorescu S.D. , Craciunescu A. , Paturca S.V. , Codreanu L. , Andrei H. , Cepisca C. , Seritan G. , Ghita O.M. , Argatu F. 
Published: November 2016

Abstract
This paper deals with a new coaxial linear permanent magnet motor. For a designed physical model of this motor, the representative magnetic spectrums are determined: the spectrum of the excitation field provided by cylindrical permanent magnet, and the spectrum of total magnetic field given by superposition of permanent magnet field and of energizing coil field.