bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast cancer with extensive bone metastasis mimicking myeloma
Authors: Hsu Ya‐Ting , Chang Kung‐Chao 
Published: January 2017

Key Clinical MessagePunched‐out lesions in skull film usually elicit consideration of myeloma. However, some other diseases cause similar clinical presentations. We describe an uncommon presentation of breast cancer, which mimics multiple myeloma. Therefore, in a broad spectrum of clinical settings, physicians should always consider differential diagnosis and await for definitive pathological diagnosis.
Rapid In Situ Immobilization of Enzymes in Metal–Organic Framework Supports under Mild Conditions
Authors: Gascón Victoria , Carucci Cristina , Jiménez Mayra B. , Blanco Rosa M. , Sánchez‐Sánchez Manuel , Magner Edmond 
Published: January 2017

AbstractThe use of a metal–organic framework (MOF) as a support for the in situ immobilization of enzymes was explored. The MOF support, a Basolite F300‐like material, was prepared from FeCl3 and the tridentate linker trimesic acid. Immobilization of alcohol dehydrogenase, lipase, and glucose oxidase was performed in situ under mild conditions (aqueous solution, neutral pH, and at room temperature) in a rapid and facile manner with retention of activity for at least 1 week. The catalytic activities of lipase and glucose oxidase were similar to the activities of the free enzymes; with alcohol dehydrogenase, there was a substantial decrease in activity on immobilization that may arise from diffusion limitations. The approach demonstrates that a MOF material, prepared from cheap and commercially available materials, can be successively utilized to prepare stable and catalytically active biocatalysts in a rapid and facile manner.
Investigation of Binding Behavior between Drug Molecule 5‐Fluoracil and M4L4‐Type Tetrahedral Cages: Selectivity, Capture, and Release
Authors: Xu Wei‐Qin , Fan Yan‐Zhong , Wang Hai‐Ping , Teng Jun , Li Yu‐Hao , Chen Cheng‐Xia , Fenske Dieter , Jiang Ji‐Jun , Su Cheng‐Yong 
Published: January 2017

AbstractTwo analogous M4L4‐type tetrahedral cages (smaller: MOC‐19; larger: MOC‐22) were synthesized and investigated for their interactions with the anticancer drug 5‐fluoracil (5‐FU) by NMR spectroscopy, high‐resolution electrospray‐ionization mass spectrometry (HR‐ESI‐MS), and molecular simulation. The cage's size and window are of importance for the host–guest binding, and consequently the smaller MOC‐19 with a more suitable size of cavity window was found to have much stronger hydrogen‐bond interactions with 5‐FU. The porous nanoparticles of MOC‐19 exhibited outstanding behavior for the controlled release of 5‐FU in a simulated human body with liquid phosphate‐buffered saline solution.
Innovative toxikologische Untersuchungsmethoden für Eisenoxidnanopartikel in der Nanomedizin
Authors: Janko Christina , Pöttler Marina , Matuszak Jasmin , Unterweger Harald , Hornung Annkathrin , Friedrich Ralf P. , Alexiou Christoph 
Published: January 2017

AbstractSuperparamagnetische Eisenoxidnanopartikel (SPIONs) bieten vielfältige Anwendungsmöglichkeiten in der Medizin. Toxikologische Untersuchungen, die auf der physikochemischen Charakterisierung der Nanopartikel aufbauen, sind eine wesentliche Voraussetzung für die zukünftige Translation in die klinische Anwendung. Da Nanopartikel mit zahlreichen klassischen toxikologischen Nachweismethoden interferieren, sind Alternativmethoden notwendig. Multiparameterfärbungen für Durchflusszytometrie und Fluoreszenzmikroskopie, markierungsfreie Echtzeitanalysen, 3D‐Zellkultur und Flussmodelle werden diskutiert.
Synthesis and metal ion uptake studies of chelating polyurethane resin containing donor atoms: Experimental optimization and temperature studies
Authors: Kirupha Selvaraj Dinesh , Narayanasamy Ramasamy , Sornalatha Manickam , Sivanesan Subramanian , Ravikumar Lingam 
Published: January 2017

AbstractNovel polyurethane (PU) bearing metal binding sites was synthesized by poly‐condensation. Synthesized polyurethane was characterized by using Fourier transformation IR spectrometry (FTIR), nuclear magnetic resonance (1H‐NMR), and thermo‐gravimetric analysis (TGA) techniques. The structural morphology of polyurethane was analyzed with scanning electron microscopy (SEM) and the polymer was used as an adsorbent for metal extraction using batch adsorption studies in aqueous media. Upon observation, it was found that maximum adsorption was obtained at pH = 6 with the adsorbent dose of 20 mg/L at 60 min of contact time for 100 mg/L of Pb(II) and Cu(II) as initial metal ion concentration. In comparison with 2‐parameter and 3‐parameter non‐linear isotherm modelling, Redlich‐Peterson adsorption model (3‐P) fits well supporting Langmuir (2‐P) compared with other sorption isotherms. From the Langmuir isotherm, maximum monolayer adsorption capacity of 496 mg/g and 481.8 mg/g for Pb(II) and Cu(II) ions were obtained, respectively. From the pseudo‐second order equation, the R2 values of Pb(II) and Cu(II) were found to be 0.9984 and 0.9958. Based on tan, the exothermic nature of adsorption is evidenced. PU was found to be stable after 5 cycles with 0.1 N H2SO4, suggesting that the synthesized polyurethane resin was chemically stable and could act as a potential adsorbent for heavy metal extractions in the aqueous media.
Cytology assessment can predict survival for patients with metastatic pancreatic neuroendocrine neoplasms
Authors: Sigel Carlie S. , Guo Huimin , Sigel Keith M. , Zhang Ming , Rekhtman Natasha , Lin Oscar , Klimstra David S. , Jungbluth Achim A. , Tang Laura K. 
Published: January 2017

BACKGROUNDHistological features and Ki‐67 index have known usefulness in predicting prognosis and guiding therapy among patients with metastatic pancreatic neuroendocrine neoplasms. Fine‐needle aspiration may offer advantages for Ki‐67 assessment because the technique obtains highly cellular, well‐preserved specimens with the potential for broader tumor sampling. In the current study, the authors evaluated concordance for grade and differentiation between concurrent core needle biopsy and cytology preparations. Cytological features and grade then were correlated with survival.METHODSDifferentiation, grade by Ki‐67 index, and correlation of these features with survival were compared between concurrent core needle biopsy and cytology specimens from 44 patients with metastatic pancreatic neuroendocrine neoplasms.RESULTSDifferentiation by cytology smear resulted in 38 cases of well (86%) and 6 cases of poor (14%) differentiation. Agreement for differentiation between smear and cell block, smear and core needle biopsy, and cell block and core needle biopsy was 88%, 94%, and 83%, respectively, and agreement for grade was 68%, 54%, and 22%, respectively. Cytology differentiation and cytology grade were found to be strong predictors of outcome with respective hazard ratios of 8.3 (95% confidence interval [95% CI], 3.1‐22.1; P<.001) and 1.9 (95% CI, 1.2‐2.9) for each ascending grade. The median disease‐specific survival cytology projections were 121 months (95% CI, 57‐185 months [estimated]) for grade 1, 45 months (95% CI, 29‐87 months) for grade 2, and 19 months (95% CI, 1‐44 months) for grade 3, with median survivals of 45 months and 3 months, respectively, for patients with well‐differentiated and poorly differentiated neuroendocrine tumors (P<.001).CONCLUSIONSGrading of pancreatic neuroendocrine neoplasms on cytology may not correlate exactly with concurrent core needle biopsy, but cytology differentiation and grade are predictive of survival based on stage‐adjusted analysis. Cancer Cytopathol 2017;125:188–196. © 2016 American Cancer Society.
Identification of a conserved cis‐regulatory element controlling mid‐diencephalic expression of mouse Six3
Authors: Lee Bumwhee , Yoon Jiyeon , Tri Lam Duc , Yoon Jaeseung , Baek Kwanghee , Jeong Yongsu 
Published: January 2017

SummaryThe sine oculis homeobox protein Six3 plays pivotal roles in the development of the brain and craniofacial structures. In humans, SIX3 haploinsufficiency results in holoprosencephaly, a defect in anterior midline formation. Although much is known about the evolutionarily conserved functions of Six3, the regulatory mechanism responsible for the expression pattern of Six3 remains relatively unexplored. To understand how the transcription of Six3 is controlled during embryogenesis, we screened ∼300 kb of genomic DNA encompassing the Six3 locus for cis‐acting regulatory elements capable of directing reporter gene expression to sites of Six3 transcription in transgenic mouse embryos. We identified a novel enhancer element, whose activity recapitulates endogenous Six3 expression in the ventral midbrain, pretectum, and thalamus. Cross‐species comparisons revealed that this Six3 brain enhancer is functionally conserved in other vertebrates. We also showed that normal Six3 transcription in the ventral midbrain and pretectum is dependent on Ascl1, a basic helix‐loop‐helix proneural factor. Moreover, loss of Ascl1 resulted in downregulation of the Six3 brain enhancer activity, emphasizing its unique role in regulating Six3 expression in the developing brain.
Optimal design and performance evaluation of systems with Tuned Mass Damper Inerter (TMDI)
Authors: Pietrosanti D. , De Angelis M. , Basili M. 
Published: January 2017

SummaryThe paper concerns the optimal design and performance evaluation of a Tuned Mass Damper Inerter (TMDI) to reduce dynamic vibrations. The system exploits properties of the inerter, a two‐terminal mechanical device able to produce a force proportional to the relative acceleration between terminals, with the ability of generating an apparent mass even two orders of magnitude greater than its own physical mass. A primary single‐degree‐of‐freedom structure is equipped with a classical linear Tuned Mass Damper (TMD), the secondary structure, whose mass is connected to the ground via an inerter. The optimal design of the TMDI is conducted by assuming a white noise process as base input and utilizing three different design methodologies: displacement minimization, acceleration minimization and maximization of the ratio between the energy dissipated in the secondary system and the total input energy. Optimal results obtained with the different methodologies are carried out and compared. Two limit cases are also considered when the inerter is not contemplated: conventional and non‐conventional TMDs, characterized by a low and a large mass ratio, respectively. The TMDI performance is evaluated and compared with conventional and non‐conventional TMDs; moreover, its robustness is assessed with a sensitivity analysis varying the design parameters. Attention is focused not exclusively on the primary structure response but also on the secondary one. Finally, the effectiveness of the optimally designed TMDI is evaluated having considered earthquake base excitation. Results demonstrate the effectiveness of TMDI systems for dynamic response reduction with superior performances and robustness than classical TMDs. Copyright © 2017 John Wiley & Sons, Ltd.
Factors predicting incidence of post‐operative delirium in older people following hip fracture surgery: a systematic review and meta‐analysis
Authors: Smith T. O. , Cooper A. , Peryer G. , Griffiths R. , Fox C. , Cross J. 
Published: January 2017

ObjectiveDelirium is one of the most common complications following hip fracture surgery in older people. This study identified pre‐ and peri‐operative factors associated with the development of post‐operative delirium following hip fracture surgery.MethodsPublished and unpublished literature were searched to identify all evidence reporting variables on patient characteristics, on‐admission, intra‐operative and post‐operative management assessing incident delirium in older people following hip fracture surgery. Pooled odds ratio (OR) and mean difference of those who experienced delirium compared to those who did not were calculated for each variable. Evidence was assessed using the Downs and Black appraisal tool and interpreted using the GRADE approach.ResultsA total of 6704 people (2090 people with post‐operative delirium) from 32 studies were analysed. There was moderate evidence of nearly a two‐times greater probability of post‐operative delirium for those aged 80 years and over (OR: 1.77; 95% CI: 1.09, 2.87), whether patients lived in a care institution pre‐admission (OR: 2.65; 95% CI: 1.79, 3.92), and a six‐times greater probability of developing post‐operative delirium with a pre‐admission diagnosis of dementia (OR: 6.07, 95% CI: 4.84, 7.62). There was no association with intra‐operative variables and probability of delirium.ConclusionClinicians treating people with a hip fracture should be vigilant towards post‐operative delirium if their patients are older, have pre‐existing cognitive impairment and poorer overall general health. This is also the case for those who experience post‐operative complications such as pneumonia or a urinary tract infection. Copyright © 2017 John Wiley & Sons, Ltd.
Alcohol Oxidations Using Reduced Polyoxovanadates
Authors: Campbell McKenzie L. , Sulejmanovic Dino , Schiller Jacqueline B. , Turner Emily M. , Hwu Shiou‐Jyh , Whitehead Daniel C. 
Published: January 2017

A full account of our recently communicated room temperature alcohol oxidation using reduced polyoxovanadates (r‐POVs) is presented. Extensive optimizations revealed optimal conditions employing 0.02 equiv. of r‐POV catalyst Cs5(V14As8O42Cl), 5 equiv. tert‐butyl hydrogen peroxide (tBuOOH) as the terminal co‐oxidant, in an acetone solvent for the quantitative oxidation of aryl‐substituted secondary alcohols to their ketone products. The substrate scope tolerates most aryl substituted secondary alcohols in good to quantitative yields while alkyl secondary and primary activated alcohols were sluggish in comparison under similar conditions. Catalyst recyclability was successful on a 1.0 mmol scale of starting alcohol 1‐phenylethanol. The oxidation was also successfully promoted by the VIV/VV mixed valent polyoxovanadate (POV) Cs11Na3Cl5(V15O36Cl). Finally, a third POV, Cs2.64(V5O9)(AsO4)2, was investigated for catalytic activity using our established reaction protocol, but proved ineffective as compared to the other two r‐POV catalysts. This study expands the field of POM‐mediated alcohol oxidations to include underexplored r‐POV catalysts. While our catalysts do not supplant the best catalysts known for the transformation, their study may inform the development of other novel oxidative transformations mediated by r‐POVs.
A pattern‐based approach to extract REA value models from business process models
Authors: Boubaker Anis , Leshob Abderrahmane , Mili Hafedh , Charif Yasmine 
Published: January 2017

SummaryBusiness models are economic models that describe the rationale of why organizations create and deliver value. These models focus on what organizations offer and why. Business process models capture business activities and the ways in which they are accomplished (i.e. their coordination). They explain who is involved in the activities, and how and when these activities should be performed. This paper discusses the alignment between business models and business process models. It proposes a novel systematic method for extracting a value chain (i.e. business model) expressed in the Resources, Events, Agents (REA) ontology from a business process model expressed in Business Process Model and Notation™. Our contribution is twofold: (1) from a theoretical standpoint we identified a set of structural and behavioural patterns that enable us to infer the corresponding REA value chain; (2) from a pragmatic perspective, our approach can be used to derive useful knowledge about the business process and serve as a starting point for business analysis.
Multifaceted effects of antimetabolite and anticancer drug, 2‐deoxyglucose on eukaryotic cancer models budding and fission yeast
Authors: Vishwanatha Akshay , D'Souza Cletus Joseph Michael 
Published: January 2017

AbstractGlycolytic inhibitors are of interest therapeutically as they are effective against cancers that display increased glycolytic rate and mitochondrial defects. 2‐Deoxyglucose (2‐DG) is one such glycolytic inhibitor and was identified to be a competitive inhibitor of glucose. Studies from past few decades have shown that the mechanism of action of 2‐DG is complex involving several metabolic and signaling pathways. Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are two important models for studying metabolism, cell cycle and cell signaling. These two unicellular eukaryotes are Crabtree positive yeasts exhibiting a metabolism similar to that of cancer cells. Effects of 2‐DG in yeast is of interest owing to these similarities and hence yeasts have emerged as ideal model organisms to study the mode of action and resistance to 2‐DG. In this review, we summarize the studies on biological effect and resistance to 2‐DG in budding and fission yeasts and give an insight into its possible mechanism of action as models for understanding cancer metabolism and drugs affecting cancer progression. © 2017 IUBMB Life, 69(3):137–147, 2017
Validity of simple clinical and biological parameters as screening tool for sickle cell anemia for referral to tertiary center in highly resource constraints
Authors: Kadima Bertin Tshimanga , Gini‐Ehungu Jean Lambert , Mbutiwi Fiston Ikwa Ndol , Bahati John Tunda , Aloni Michel Ntetani 
Published: January 2017

BackgroundIn the Democratic Republic of Congo, the incidence of sickle cell anemia (SCA) is estimated around 40 000 neonates per year. However, it is notoriously difficult to perform conventional electrophoresis in all hospitals and laboratories, especially at peripheral levels and rural area. A panel of multiple clinical and laboratory features that would enhance sickle cell disease were assessed for the detection of the disease in highly resource‐scarce settings.MethodsA prospective study was conducted in Kinshasa. Venous blood samples were drawn from each study participant in order to determine the hematologic parameters, the peripheral smears, and the hemoglobin electrophoresis. We used Cohen's κ statistic to examine the agreement of each variable and diagnosis of sickle cell disease.ResultsA total of 807 patients were screened for sickle cell disease. Among these 807 children, 36 (4.5%) were homozygous for Hb S disease. The presence of at least 8% erythroblasts (PPV: 91%, NPV: 99%, sensitivity: 83.3%, specificity: 99.6%, κ value: .86) and sickle cells (PPV:100%, NPV: 98%, sensitivity: 50%, specificity: 100%, κ value: .66) in the peripheral blood smear had an acceptable agreement for sickle cell disease.ConclusionThese two biological markers may guide the clinician in the decision‐making to initiate the management of the children as a sickle cell patient, pending confirmation of the disease by electrophoresis techniques.
Phosphorus removal by marine bacterium enhanced with iron in the presence of silicon
Authors: Wang Yanru , Sun Cuiping , Wang Zhende , Zhao Haixia , Zhang Yu‐Zhong , Zhou Weizhi 
Published: January 2017

AbstractBACKGROUNDSeeking efficient phosphorus (P) removal methods is of great significance in both aspects of environmental protection and resource conservation. Silicon (Si) is always present in marine sediments and it contributes significantly to P removal by iron (Fe(III)) oxides. Marine microbes play the major role in marine biomineralization. The aim of this study was to investigate P removal performance by marine bacterium enhanced with Fe (III) in the presence of Si and the role Si played in the system.RESULTSThe optimal Fe/Si/P molar ratio for P removal was 1:1.5:1. P removal efficiency was 47.79%, 96.02%, and 97.87% in systems of pure bacterial cultures, bacteria with Fe (III), and bacteria with Fe (III) and Si, respectively, at P of 30 mg L−1. Flocs and micro‐precipitates were formed around cells in P removal systems containing Fe (III) or Si. Moreover, the amount and size of flocs in systems containing Si were larger than those without Si.CONCLUSIONP removal by marine bacterium enhanced with Fe (III) had good performance through precipitation and adsorption. Si was able to strengthen P removal ability and sludge settleability. This study can provide us with new insights into bacterial induced metal phosphate precipitate and into the marine P cycle. © 2017 Society of Chemical Industry
Improving and Quantifying the Process Window
Authors: Deile Jochen , Gäbler Frank 
Published: January 2017

Abstract Femtosecond lasers bring numerous process‐enabling advantages to precision microprocessing applications. However, taking a new, ultrafast laser‐based application from a first demonstration to full‐blown manufacturing at market‐enabling throughput rates is usually more difficult than for longer pulsewidth lasers. This is because processes utilizing nanosecond (and longer) pulsewidth lasers can rely on a massive knowledge base, built up by laser manufacturers, systems builders and end users, over decades of application. In contrast, femtosecond laser processing is very much in its infancy, with a limited body of proven applications (or even research and development) to draw on. In this article, we describe how a process window was defined, improved, and finalized in the specific case of precision cutting of thin glass panels for display applications.
Diode Laser Systems for Industrial Metal Processing
Authors: Neukum Jörg , Horn Wolfgang 
Published: January 2017

AbstractHigh power diode laser systems are widely spread in the industry. Whereas systems with several hundred watts are used for plastic welding and soldering, mainly in automotive, medical device and consumer applications, kW‐class diode lasers systems are used in metal processing applications to a large extent. Some direct beam applications use beam shaping to facilitate hardening of knife edges in industrial applications. The majority of applications take advantage fiber‐coupled solutions, of in robotic applications for example. Here, we describe the concept from chip level, via automated beam shaping, up to fully integrated, fiber‐coupled, kW‐class, turn‐key diode laser systems.
Laser + Camera = Innovation
Authors: Lehmann Wolfgang 
Published: January 2017

AbstractThe use of modern laser technology has become standard in industrial manufacturing thanks to its speed, accuracy and effectiveness. Lasers are used to engrave parts, electronic printed circuit boards or chip cards. They perforate packaging, structure semiconductor wafers, drill, cut and weld plastics or metals, and create highly complex structures via 3D printing — all contactless, with no application of force and wear‐free.
Cost‐Effective Polymethacrylate‐Based Electrospun Fluorescent Fibers toward Ammonia Sensing
Authors: Petropoulou Afroditi , Christodoulou Kyriakos , Polydorou Christiana , Krasia‐Christoforou Theodora , Riziotis Christos 
Published: January 2017

The fabrication of cost‐effective, polymer‐based electrospun fluorescent fibrous grids and their evaluation as candidates for sensing is reported, drawing useful results on their applicability and efficiency in gas sensing applications. A well‐defined, methacrylic homopolymer functionalized with anthracene moieties as fluorescent elements has been blended with a commercially available poly(methyl methacrylate) for the production of fluorescent electrospun polymer fibers. The formation of 3D grids can provide large interaction area with gas analytes and thus overcome quenching limitations induced by polymeric films, for more efficient sensing. These materials have been evaluated for ammonia sensing based on the fluorescence quenching of the anthracene fluorophores in the presence of ammonia vapors, exhibiting fast response at concentration up to 10 000 ppm. The covalent bonding of the anthracene fluorophore onto a hydrophobic polymethacrylate‐based backbone enables the future exploitation of the presented materials in sensing applications involving metal ions and biomolecules in aqueous media.
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