bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indication Criteria for Total Knee Arthroplasty in Patients with Osteoarthritis – A Multi-perspective Consensus Study
Authors: Schmitt Jochen , Lange Toni , Günther Klaus-Peter , Kopkow Christian , Rataj Elisabeth , Apfelbacher Christian , Aringer Martin , Böhle Eckhardt , Bork Hartmut , Dreinhöfer Karsten , Friederich Niklaus , Frosch Karl-Heinz , Gravius Sascha , Gromnica-Ihle Erika , Heller Karl-Dieter , Kirschner Stephan , Kladny Bernd , Kohlhof Hendrik , Kremer Michael , Leuchten Nicolai , Lippmann Maike , Malzahn Jürgen , Meyer Heiko , Sabatowski Rainer , Scharf Hanns-Peter , Stoeve Johannes , Wagner Richard , Lützner Jörg 
Published: October 2017

Abstract
Background and Objectives Knee osteoarthritis (OA) is a significant public health burden. Rates of total knee arthroplasty (TKA) in OA vary substantially between geographical regions, most likely due to the lack of standardised indication criteria. We set out to define indication criteria for the German healthcare system for TKA in patients with knee OA, on the basis of best evidence and transparent multi-stakeholder consensus.
Methods We undertook a complex mixed methods study, including an iterative process of systematic appraisal of existing evidence, Delphi consensus methods and stakeholder conferences. We established a consensus panel representing key German national societies of healthcare providers (orthopaedic surgeons, rheumatologists, pain physicians, psychologists, physiotherapists), payers, and patient representatives. A priori defined consensus criteria were at least 70% agreement and less than 20% disagreement among the consensus panel. Agreement was sought for (1) core indication criteria defined as criteria that must be met to consider TKA in a normal patient with knee OA, (2) additional (not obligatory) indication criteria, (3) absolute contraindication criteria that generally prohibit TKA, and (4) risk factors that do not prohibit TKA, but usually do not lead to a recommendation for TKA.
Results The following 5 core indication criteria were agreed within the panel: 1. intermittent (several times per week) or constant knee pain for at least 3 – 6 months; 2. radiological confirmation of structural knee damage (osteoarthritis, osteonecrosis); 3. inadequate response to conservative treatment, including pharmacological and non-pharmacological treatment for at least 3 – 6 months; 4. adverse impact of knee disease on patientʼs quality of life for at least 3 – 6 months; 5. patient-reported suffering/impairment due to knee disease. Additional indication criteria, contraindication criteria, and risk factors for adverse outcome were also agreed by a large majority within the multi-perspective stakeholder panel.
Conclusion The defined indication criteria constitute a prerequisite for appropriate provision of TKA in patients with knee OA in Germany. In eligible patients, shared-decision making should eventually determine if TKA is performed or not. The next important steps are the implementation of the defined indication criteria, and the prospective investigation of predictors of success or failure of TKA in the context of routine care provision in Germany.
Mammakarzinom – komplementäre Praxis
Authors: Wey Stephan 
Published: October 2017

ZusammenfassungKomplementäre onkologische Therapieverfahren ergänzen und bereichern die konventionellen Therapien der evidenzbasierten Schulmedizin (OP,
Strahlen-, Chemo- und Antihormontherapie u. a.). Dazu gehören Methoden, die in jedem Stadium einer Krebserkrankung sinnvoll in ein
koordiniertes Gesamtkonzept durch die behandelnden Chirurgen, Onkologen, Strahlentherapeuten und einem komplementären Arzt eingebettet sein
sollten sowie vom Patienten selbst angewendet werden können und die von einer erweiterten Diagnostik über allgemeine Basismaßnahmen über
Bewegung und Ernährung bis hin zur Anwendung von orthomolekularen Substanzen, Phytotherapie und sekundärer Pflanzenstoffe sowie weiterer
komplementärer Verfahren reichen.
Curcuma longa in der Onkologie
Authors: Kneer Vera Maria 
Published: October 2017

ZusammenfassungCurcuma longa wird seit Jahrtausenden in der ayurvedischen und chinesischen Medizin bei zahlreichen Erkrankungen eingesetzt. Im Mittelpunkt
der Forschung steht überwiegend Curcumin, ein wesentlicher Bestandteil des Extrakts. In-vitro- und In-vivo-Studien haben vielfältige
Wirkmechanismen u. a. antioxidative und antiinflammatorische Wirkungen aufgezeigt. Bei zahlreichen Erkrankungen, v. a. mit entzündlicher
Genese sowie bei Tumorerkrankungen, hat sich der Einsatz von Curcumin als effektiv erwiesen. Curcumin beeinflusst alle Signalwege von der
Karzinogenese bis zur Metastasierung. Formulierungen mit verbesserter Bioverfügbarkeit sowie neue Applikationsformen versuchen
pharmakologische Schwächen des Pflanzenstoffes auszugleichen. Aktuell werden in Patientenstudien z. B. Kombinationen mit Chemotherapien und
Strahlentherapien erprobt. Daneben sind aber auch Kombinationen von Curcuma mit anderen Pflanzenstoffen zur Optimierung therapeutischer
Effekte in der integrativen Onkologie von großem Interesse.
Behandlungsfehlervorwürfe gegen Pädiater – eine Analyse von Gutachten des Medizinischen Dienstes der Krankenversicherung der Jahre 2000 bis 2014
Authors: Steinhauer Heiko , Holzschuh Joachim , Böhler Thomas 
Published: October 2017

Zusammenfassung
Hintergrund In Deutschland gibt es bislang nur wenige Informationen zu spezifisch gegen Pädiater gerichtete Vorwürfe medizinischer Behandlungsfehler (BHF). Der Medizinische Dienst der Krankenversicherung (MDK) begutachtet im Auftrag der gesetzlichen Krankenkassen regelmäßig BHF-Vorwürfe bei pädiatrischer Behandlung.
Methoden Analyse von 374 Gutachten, die zwischen dem 01.09.2000 und 31.08.2014 durch einen pädiatrischen Gutachter des MDK Baden-Württemberg erstellt wurden.
Ergebnisse 193 BHF-Vorwürfe gegen Pädiater wurden getrennt nach Versorgungssektoren ausgewertet (ambulant 35%, Normalstation 28%, Intensivstation 37%). Bei ambulanter Behandlung wurden häufiger Diagnosefehler vorgeworfen; die häufigsten begründenden Diagnosen waren Hüftdysplasie (n=6), Meningitis (n=5) und Pneumonie (n=4). Bei stationärer Behandlung wurden häufiger Therapiefehler vorgeworfen; häufigste begründende Diagnosen waren: Paravasate (n=7) sowie periventrikuläre Leukomalazie (n=7), Sepsis (n=6) und Hirnblutung (n=4) bei Neugeborenen auf Intensivstationen. 43% der ambulanten, 22% der normalstationären und 38% der intensivstationären BHF-Vorwürfe wurden gutachterlich bestätigt.
Diskussion und Schlussfolgerung Die Häufigkeiten von BHF-Vorwürfen scheinen in erster Linie von der Häufigkeit der Inanspruchnahme kinder- und jugendmedizinischer Leistungen abzuhängen. International bekannte diagnosespezifische Fallkonstellationen geben auch in Deutschland gehäuft Anlass zu einem BHF-Vorwurf. Die Analyse der Fälle nach Versorgungssektoren lässt nachvollziehbare Rückschlüsse für ein Risikomanagement zu.
Palliative Behandlung von Patienten mit fortgeschrittenem Pankreaskarzinom
Authors: Schad Friedemann 
Published: October 2017

ZusammenfassungIntegrative onkologische Therapiekonzepte sind eine Kombination aus konventionellen und komplementären Therapien. Die vorliegende
multizentrische Registerstudie untersuchte die Umsetzung von integrativen onkologischen Therapiekonzepten und der Assoziation mit dem
Überleben von Patienten im fortgeschrittenen Stadium IV bei Bauchspeicheldrüsenkrebs unter Gabe von Mistelextrakten – mit positiven
Effekten: Patienten mit kombinierter Chemo- und Misteltherapie zeigten einen statistisch signifikant besseren Überlebensvorteil als
Patienten mit alleiniger Chemotherapie; Patienten, die nur eine Misteltherapie erhielten, zeigten statistisch signifikant längere
Überlebensraten als jene, die weder Chemotherapie noch Misteltherapie erhielten.
Syllable type development in toddlers acquiring Dutch
Authors: van den Berg Renate , Van Severen Lieve , Molemans Inge , Gillis Steven 
Published: October 2017

Abstract
Compiling syllable type inventories from children’s spontaneous speech is all but straightforward: so far studies vary considerably in their methodologies and consequently the selection of the speech samples differs. This paper shows that different methodologies for selecting a speech sample lead to substantial differences in syllable inventories. Two main sources for this variation are explored: differences in size and content of the speech samples. Both factors influence the results significantly and this questions the comparability of previous study results. An empirical procedure to investigate syllable type development is proposed to overcome such methodological problems, and this procedure is implemented to provide an initial empirically sound assessment of the acquisition of syllable types in Dutch speaking toddlers.
Using cognitive general imagery to improve soccer strategies
Authors: Munroe‐Chandler Krista J. , Hall Craig R. , Fishburne Graham J. , Shannon Vanessa 
Published: October 2017

AbstractAthletes use imagery for both cognitive and motivational functions (Paivio 1985) The cognitive function involves the rehearsal of skills (cognitive specific) and strategies of play (cognitive general). To date most of the imagery research has been concerned with skill rehearsal (cognitive specific), and there have been no controlled studies investigating the effects of cognitive general imagery on the learning and performance of game plans or strategies of play. The purpose of this study was to determine the effectiveness of a cognitive general imagery intervention on three distinct soccer strategies in a young elite female soccer team. Participants were 13 competitive female soccer players with a mean age of 12.54 years. Imagery scores were determined via the Sport Imagery Questionnaire (SIQ; Hall, Mack, Paivio, & Hausenblas, 1998) prior to, during, and after the intervention. A staggered multiple baseline design across behaviors was used to evaluate the effect of imagery on three distinct soccer strategies (defending a direct free kick, taking a direct free kick, and defending a corner kick) which were introduced at weeks 2, 4 and 6. Results indicated that cognitive general and cognitive specific imagery use as well as motivational general‐arousal imagery use significantly increased from baseline to post intervention. Based on the present study's findings, the execution of soccer strategies was not significantly enhanced with the implementation of a cognitive general intervention. Additional research should be conducted in order to reach clearer conclusions that will have implications for young athletes and their learning strategies.
DISC: DISulfide linkage Characterization from tandem mass spectra
Authors: Liu Yi , Sun Weiping , Shan Baozhen , Zhang Kaizhong 
Published: October 2017

Abstract

Motivation
Enzymatic digestion under appropriate reducing conditions followed by mass spectrometry analysis has emerged as the primary method for disulfide bond analysis. The large amount of mass spectral data collected in the mass spectrometry experiment requires effective computational approaches to automate the interpretation process. Although different approaches have been developed for such purpose, they always choose to ignore the frequently observed internal ion fragments and they lack a reasonable quality control strategy and calibrated scoring scheme for the statistical validation and ranking of the reported results.

Results
In this research, we present a new computational approach, DISC (DISulfide bond Characterization), for matching an input MS/MS spectrum against the putative disulfide linkage structures hypothetically constructed from the protein database. More specifically, we consider different ion types including a variety of internal ions that frequently observed in mass spectra resulted from disulfide linked peptides, and introduce an effective two-layer scoring scheme to evaluate the significance of the matching between spectrum and structure, based on which we have also developed a useful target-decoy strategy for providing quality control and reporting false discovery rate in the final results. Systematic experiments conducted on both low-complexity and high-complexity datasets demonstrated the efficiency of our proposed method for the identification of disulfide bonds from MS/MS spectra, and showed its potential in characterizing disulfide bonds at the proteome scale instead of just a single protein.

Availability and implementation
Software is available for downloading at http://www.csd.uwo.ca/yliu766/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Astrocyte-Specific Deletion of Sox2 Promotes Functional Recovery After Traumatic Brain Injury
Authors: Chen Chunhai , Zhong Xiaoling , Smith Derek K , Tai Wenjiao , Yang Jianjing , Zou Yuhua , Wang Lei-Lei , Sun Jiahong , Qin Song , Zhang Chun-Li 
Published: October 2017

AbstractInjury to the adult brain induces activation of local astrocytes, which serves as a compensatory response that modulates tissue damage and recovery. However, the mechanism governing astrocyte activation during brain injury remains largely unknown. Here we provide in vivo evidence that SOX2, a transcription factor critical for stem cells and brain development, is also required for injury-induced activation of adult cortical astrocytes. Genome-wide chromatin immunoprecipitation-seq analysis of mouse cortical tissues reveals that SOX2 binds to regulatory regions of genes associated with signaling pathways that control glial cell activation, such as Nr2e1, Mmd2, Wnt7a, and Akt2. Astrocyte-specific deletion of Sox2 in adult mice greatly diminishes glial response to controlled cortical impact injury and, most unexpectedly, dampens injury-induced cortical loss and benefits behavioral recovery of mice after injury. Together, these results uncover an essential role of SOX2 in somatic cells under pathological conditions and indicate that SOX2-dependent astrocyte activation could be targeted for functional recovery after traumatic brain injury.
Assessing the capacity of social determinants of health data to augment predictive models identifying patients in need of wraparound social services
Authors: Kasthurirathne Suranga N , Vest Joshua R , Menachemi Nir , Halverson Paul K , Grannis Shaun J 
Published: October 2017

Abstract

Introduction
A growing variety of diverse data sources is emerging to better inform health care delivery and health outcomes. We sought to evaluate the capacity for clinical, socioeconomic, and public health data sources to predict the need for various social service referrals among patients at a safety-net hospital.

Materials and Methods
We integrated patient clinical data and community-level data representing patients’ social determinants of health (SDH) obtained from multiple sources to build random forest decision models to predict the need for any, mental health, dietitian, social work, or other SDH service referrals. To assess the impact of SDH on improving performance, we built separate decision models using clinical and SDH determinants and clinical data only.

Results
Decision models predicting the need for any, mental health, and dietitian referrals yielded sensitivity, specificity, and accuracy measures ranging between 60% and 75%. Specificity and accuracy scores for social work and other SDH services ranged between 67% and 77%, while sensitivity scores were between 50% and 63%. Area under the receiver operating characteristic curve values for the decision models ranged between 70% and 78%. Models for predicting the need for any services reported positive predictive values between 65% and 73%. Positive predictive values for predicting individual outcomes were below 40%.

Discussion
The need for various social service referrals can be predicted with considerable accuracy using a wide range of readily available clinical and community data that measure socioeconomic and public health conditions. While the use of SDH did not result in significant performance improvements, our approach represents a novel and important application of risk predictive modeling.
Systematic Government Access to Private-Sector Data in Germany
Authors: Schwartz Paul M. 
Published: October 2017

Abstract
This chapter covers German law as it applies to government access to private-sector data. German law has long been strongly committed to informational privacy. Its protections are found at the constitutional and statutory levels. At the same time, legislation over the last two decades has expanded the ability of the government, including police and intelligence agencies, to process, store, and share personal information. The resulting databanks create elements of systematic access to personal data in Germany. At the same time, German unease with systematic data access is shown by the ongoing controversies with data retention and the abandoned ELENA process. Complex questions have also been raised by private sector attempts to create a Germany-only “cloud” as well as the significant and ongoing collaboration between German and US intelligence agencies.
Systematic Government Access to Private-Sector Data in Israel
Authors: Tene Omer 
Published: October 2017

Abstract
Israel is a democracy committed to the protection of human rights while at the same time trying to contain uniquely difficult national security concerns. One area where this tension is manifest is government access to communications data. On the one hand, subscriber privacy is a constitutional right protected by legislation and Supreme Court jurisprudence; on the other hand, communications data are a powerful tool in the hands of national security and law enforcement agencies. This chapter examines Israel’s attempt to balance these competing interests by empowering national security agencies while at the same time creating mechanisms of accountability. In particular, Israel utilizes the special independent status of the attorney general as a check on government power.
Systematic Government Access to Private-Sector Data in Canada
Authors: Bailey Jane , Shayan Sara 
Published: October 2017

Abstract
This chapter focuses on Canadian law as it applies to government access to private-sector data. The Canadian Charter of Rights and Freedoms implicitly provides constitutional protection of privacy by prohibiting unreasonable search and seizure by the state (s. 8) and by limiting government intrusion on life, liberty and security of the person (s. 7). With some exceptions, the Charter requires law enforcement agencies to seek prior authorization before accessing personal information. However, Canada’s national security intelligence agencies are subject to more relaxed standards. The Privacy Act regulates federal government institutions’ relationship with personal information, whereas the private sector is regulated by the Personal Information and Protection of Electronic Documents Act. However, numerous exceptions in both statutes allow for (and in some cases encourage), information sharing between private-sector and state entities.
Systematic Government Access to Private-Sector Data in the United States I
Authors: Pell Stephanie K. 
Published: October 2017

Abstract
After the September 11 attacks, law enforcement's mission expanded to include, at times even prioritize, the general “prevention, deterrence and disruption” of terrorist attacks, which presumed a new emphasis upon threat detection and identification by analyzing patterns in larger, less specific bodies of information. Indeed, the unprecedented level of “third-party” possession of information inevitably makes the private sector the most reliable and comprehensive source of information available to law enforcement and intelligence agencies alike. This chapter explores the potential applications of systematic government access to data held by third-party private-sector intermediaries that would not be considered public information sources but, rather, data generated based on the role these intermediaries play in facilitating economic and business transactions (including personal business, such as buying groceries or staying at a hotel on vacation).
Systematic Government Access to Private-Sector Data in Australia
Authors: Svantesson Dan Jerker B. , Azzopardi Rebecca 
Published: October 2017

Abstract
The chapter provides a summary of Australian privacy law including the Privacy Act and the Australian Privacy Principles. After describing the national legal context and fundamental principles governing Australia’s federal system of government with power distributed among six states, two territories, and the federal government, it describes laws separately governing law enforcement and intelligence agencies, including the Australian Security Intelligence Organisation (ASIO). The authors suggest that, although the Australian government has a range of powers to obtain private-sector data, those powers appear primarily aimed at obtaining specific data for specific purposes. Little was found by way of direct unmediated access by the government to private-sector data or government access to private-sector data in bulk.
Systematic Government Access to Private-Sector Data in Japan
Authors: Tsuchiya Motohiro 
Published: October 2017

Abstract
The Japanese legal system has been based on the German legal system since the mid-nineteenth century, but the American legal system was grafted onto it following Japan’s defeat in World War II in 1945. The postwar Constitution contained an article regarding the secrecy of communications and protected privacy in terms of respect of individuals. Now, as the Personal Information Protection Law in the Executive Branch, which was enacted in 1988, and the Personal Information Protection Law, which was enacted in 2003, strictly regulate privacy, there have been fewer problematic cases regarding governmental access to private-sector data. Data gathering for law enforcement or intelligence activities has also been weaker following World War II. Private-sector corporations/organizations might share data with government agencies, but based on voluntary arrangements, not by any mandatory system. More focus is being cast not on governmental access to private-sector data, but on citizen’s access to data.
Systematic Government Access to Private-Sector Data in the Republic of Korea
Authors: Jong Sang Jo 
Published: October 2017

Abstract
This chapter examines the statutory grounds for governmental access to private-sector data in Korea. It focuses on issues such as the circumstances under which access is allowed without a warrant and how unjustified government access can take place in practice. Systematic government access to private-sector data can take place through warrants issued by a court. Notably, due to the unique truce situation, under which the Republic of Korea is technically still at war with North Korea, Korean authorities are sometimes allowed to obtain private-sector data without warrants, for national security purposes. This chapter examines the statutory grounds for governmental access to private-sector data in Korea, focusing specifically on issues such as the circumstances under which access is allowed without a warrant and how unjustified government access can take place in practice.
Preventing the Police State
Authors: Vincent Sarah St. 
Published: October 2017

Abstract
This chapter is intended as a basic reference guide for lawyers, legislators, and advocates approaching the issue of mass surveillance—or surveillance more generally—through the lens of international human rights law for the first time. It focuses on the International Covenant on Civil and Political Rights and the human rights treaties that apply in Europe and the Americas, with a particular emphasis on the rights to privacy, freedom of expression and opinion, and an effective remedy for violations. Although the exact parameters of the right to privacy are still being decided, it appears increasingly clear that state interferences with any kind of communications data will generally be subject to a standard of strict necessity applied on an individualized basis, and there is presently a trend toward finding that mass surveillance—including systematic state access to data held or transmitted by the private sector—violates the human rights treaties.