bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling Potent Anti-Asthmatic Effect of Curcumin in Combination with Salmeterol in Swiss Albino Mice
Authors: Samanta Sairashmi , Y Jyothi , Bihani Manisha , Gurung Sushil , Chettri Rohit , Mahato Ankit Kumar , Chhetri Royan , K R Roopesh , D R Nishanth 
Published: October 2024

Background: Asthma is a long-term inflammatory respiratory condition marked by alterations in the airways and an increase in inflammatory cell infiltration. It has been observed that Curcumin possesses immune-modulating, anti-inflammatory, and relaxing properties for smooth muscle in the airways. Salmeterol is believed to ease the smooth muscles of the airways.
Objective: Swiss Albino mice were used in the research to examine the combination anti-asthmatic effects of Curcumin and Salmeterol in asthma produced by ova albumin and milk induced eosinophilia and leucocytosis.
Methods: The mice received pre-treatment with Curcumin (10 mg/kg, 20 mg/kg intraperitoneally) as well as Salmeterol (5 mg/kg) after being stimulated with an Ovalbumin (OVA) challenge and milk. After the induction period, various hematological, biochemical, molecular (ELISA), and histological analyses were performed.
Results: The findings demonstrated that the combined treatment decreased the animal’s overall leukocyte and eosinophil numbers in a manner that was dose-dependent. Additionally, the therapy reduced albumin and overall protein amount in serum, BALF and lung tissues, facilitated changes in haematological parameters, and reduced the rise of Th2 cytokines (IL-4, TNF-α, IL-13) levels that is induced by OVA in lungs and BALF, total IgE level in serum. The combined action of Curcumin and Salmeterol reduced OVA-induced inflammatory influx and ultrastructural abnormalities, according to histopathological evaluation.
Conclusion: The findings of this investigation demonstrate that curcumin and salmeterol together possess anti-asthmatic effects through suppressing Th2 triggered immune response and possessing an anti-inflammatory effect and anti-allergic effect. Thus combination of treatments might be a novel technique for managing asthma.
Pengembangan Media Kartu Bergambar Berbasis Nilai Moral dalam Mengoptimalkan Kreativitas Menulis Pantun
Authors: Rahmadini Irene , Sumardi Aida 
Published: October 2024

Peserta didik kelas VII mengalami kesulitan dalam membuat pantun dikarenakan peserta didik memiliki kendala untuk menentukan ide awal pembuatan pantun tersebut. Pantun dapat dijadikan sebuah medium peserta didik mempelajari dan meningkatkan nilai moral dalam kehidupan sehari-hari yang kini peserta didik kurang menerapkan nilai moral dengan baik. Selain itu, media pembelajaran untuk pembelajaran pantun guna membantu peserta didik menemukan ide membuat pantun masih minim. Hal tersebut menjadi sebuah tantangan bagi pengajar bahasa Indonesia kelas VII dalam membantu peserta didik menemukan ide membuat pantun yang dapat memiliki keterkaitan dengan nilai moral secara bersamaan. Oleh sebab itu, penelitian ini memiliki tujuan mengembangkan media pembelajaran dalam bentuk kartu bergambar yang dapat membantu pengajar memadukan ide awal membuat pantun dan nilai moral. Model pengembangan yang digunakan dalam penelitian ini ialah Research and Development dengan menggunakan teori ADDIE. Teknik pengumpulan data dalam penelitian ini berupa wawancara dengan pengajar bahasa Indonesia kelas VII dan pengisian angket yang dilakukan oleh peserta didik kelas VII. Hasil penelitian pengembangan produk dalam penelitian ini memiliki rata-rata respon dari 95 peserta didik sebesar 86% dengan memperoleh kriteria sangat layak. Dengan presentase tersebut, media pembelajaran yang telah dikembangkan dapat dimanfaatkan dan digunakan dalam pembelajaran menulis pantun berbasis nilai moral di kelas VII.
Temporal adverbs in linguistic constructions as an object of linguistic research
Authors: Назаров А.Л. 
Published: October 2024

время представляет интерес в аспекте когнитивных процессов, нашедших отражение в семантике в том числе адъективных единиц языках, участвующих в концептуализации мира. Данная работа посвящена анализу степени изученности наречий, выражающих временные характеристики в контексте русского языкознания. Исследование рассматривает историю вопроса. В работе изучаются методики и подходы к описанию временных индикаторов, прослеживаются ключевые этапы и направления развития концепции времени в лингвистике, выявляется особенность классификации и восприятия времени, а также анализируются способы репрезентации времени в языке. Авторами рассматриваются и описываются фундаментальные свойства времени, которые отражаются в значениях наречий. Объектом исследования являются наречия времени. Отмечается, что они занимают центральное место в изучаемом лексико-семантическом поле, так как выступают как конкретными временными индикаторами, так и используются для сопоставления действий и событий на временной оси относительно друг друга или других точек отсчета. Актуальность работы заключается в систематизации результатов исследований, касающихся наречий времени, а также в описании функций наречия времени «мгновенно» с целью семантико-прагматического описания выбранного слова в его современном виде, раскрывающие свойства исключительности наречия.
time is of interest in the aspect of cognitive processes, reflected in semantics, including adjective units of languages involved in the conceptualization of the world. This work is devoted to the analysis of the degree of study of adverbs expressing temporal characteristics in the context of Russian linguistics. The study examines the background of the issue. The paper examines methods and approaches to the description of time indicators, traces the key stages and directions of the development of the concept of time in linguistics, identifies the peculiarity of the classification and perception of time, and analyzes the ways of representing time in language. The authors consider and describe the fundamental properties of time, which are reflected in the meanings of adverbs. The object of the study is the adverbs of time. It is noted that they occupy a central place in the studied lexico-semantic field, as they act as specific time indicators, and are used to compare actions and events on the time axis relative to each other or other reference points. The relevance of the work lies in the systematization of the results of research concerning the adverbs of time, as well as in the description of the functions of the adverb of time «instantly» in order to semantically and pragmatically describe the selected word in its modern form, revealing the properties of the exclusivity of the adverb.
Overview of semantic field analysis methods
Authors: Уразаев М.Д. 
Published: October 2024

семантическое поле в лексико-типологических исследованиях представляет собой языковую структуру, объединяющую единицы на основе общих семантических признаков. Оно характеризуется системными парадигматическими отношениями, относительной автономностью и наличием ядра и периферии. Отношения в поле могут быть тождественными, включающими, пересекающимися или дизъюнктивными. Семантическое поле анализируется как система согласовательных классов, учитывая как парадигматические, так и синтагматические связи. Верификация данных и проверка на соответствие языковому сознанию носителей языка важны для адекватного анализа лексических единицы семантического поля. Методы исследования семантического поля могут быть классифицированы как методы выделения поля, исследования его парадигматики и синтагмики.
the semantic field in lexico-typological research is a linguistic structure that unites lexical units based on common semantic features. It is characterized by systemic paradigmatic relationships, relative autonomy, and the presence of a core and periphery. Relationships within a field can be identical, inclusive, intersecting, or disjunctive. The semantic field is analyzed as a system of concordant classes, taking into account both paradigmatic and syntagmatic connections. Data verification and checking for compliance with the linguistic consciousness of native speakers are important for an adequate analysis of the lexical units within the semantic field. Methods for studying the semantic field can be classified into methods for isolating the field and studying its paradigmatics and syntagmatics.
Pollen Cross-Reactivity: A Primer for Allergy Specialists
Authors: Sowers Tricia 
Published: October 2024

There are over 400,000 land-based plant species that comprise our biodiverse habitat. Only a small subset of those plant species satisfies Thommen’s postulates, classifying them as allergens. The number of allergenic species, however, remains so vast that it is prohibitive to both test and treat for all relevant species within a geographical region. Allergy specialists have a valuable tool that can be used to help simplify the management of allergic patients: cross-reactivity.
Cross-reactivity is the ability for an allergen to induce an IgE-mediated response, regardless of previous exposure. Allergens are a complex milieu of proteins, some of which have allergic potential while others do not. A number of proteins are conserved across allergen species. When exposure to these conserved proteins occurs, the immune system recognizes them in a similar manner. For homologous or cross-reactive allergenic proteins, this conserved molecular recognition initiates the allergic cascade. Allergen characterization is critical to the understanding of cross-reactivity. Characterization, in this context, refers to the protein make-up of a particular allergen. The process of allergen characterization began in 1962 with the discovery of antigen E, the first identified allergenic protein. Antigen E, commonly known as Amb a 1, is an allergenic protein in ragweed, and is the primary sensitizing protein for ragweed allergy sufferers. These primary sensitizers are referred to as major allergens and can be defined as such when >50% of the allergic patient population is sensitized to them. An entire branch of research arose from this discovery, which has allowed for major advances to be made in the understanding of cross‑reactive relationships among allergen species. Cross‑reactivity is not limited to homologous major allergen expression. Rather, minor allergens and panallergens, though less clinically relevant, play a similar role in cross‑reactive relationships. This primer will explore the science behind cross‑reactivity, as well as provide a general overview of the cross‑reactive relationships that have been defined for plant allergens found across North America.
Redes vivas de saúde frente às maternidades sequestradas
Authors: Simões de Souza Isadora , Gonçalves Vicentin Maria Cristina 
Published: October 2024

Neste texto discutimos a produção de redes de saúde como estratégia de enfrentamento ao intolerável da retirada de bebês, mais especificamente daquelas mulheres em situação de rua e/ou usuárias de drogas, que passam a ter seus direitos cerceados, como o de ver ou serem informadas do paradeiro institucional de seus filhos. Visando compreender tal operação, que chamamos de sequestro, traçamos, por meio de entrevistas, os itinerários de mulheres usuárias de drogas que lutam para reaver ou reconstruir a história de seus filhos, bem como as ações de profissionais que construíram estratégias de enfrentamento destas violações. Tomando como fio condutor duas histórias que se entrecruzam, na cidade de Belo Horizonte, a de uma mãe e a de uma médica pediatra, evidenciamos: o desmentido como modo de operar o sequestro e a configuração de “redes vivas” como caminho do cuidado em resposta à “rede fria” da violência de estado.
Different Nitrogen Levels with Nano and Prilled Urea Spray on Productivity and Profitability of Maize (Zea mays L.) in alfisols of Jharkhand
Authors: SATYAM RAWAT  , RAJIV KUMAR SINGH  , PK UPADHYAY  , PREETI SINGH  , KAPILA SHEKHAWAT  , SEEMA SANGWAN  , SUKANTA DASH  , BIJAN KUMAR MONDAL  , RAJAN SHUKLA  
Published: October 2024

A ground-breaking and enduring way to significantly reduce the use of conventional nitrogen fertilizer is to use nano-urea as a nitrogen supplement. The combination of nano and prilled urea was investigated in this study to address this issue and allowing for a 25% reduction in the recommended urea dosage. Research on rainfed maize during kharif season was conducted at ICAR-IARI Jharkhand. Twelve different combinations of conventional prilled urea, nano and prilled urea spray were investigated in the study. In the fields, the experiment used a randomized block design. Different treatments included applying prilled urea as a 2% solution in 150 liters of water per hectare and nano-urea at a rate of 1250 ml/acre applied twice through foliar application. Results showed that applying two additional applications of nano-urea along with 75% of the recommended dose of prilled-urea was the most successful fertilization strategy. This performed statistically equal with both the 100% recommended dose and the 100% recommended dose with two prilled urea spray applications in terms of yield, and cost-to-benefit ratio. The study's findings show that nano-urea can safely replace at least 25% of the dosage of prilled urea i.e. recommended, providing a more profitable and environmentally friendly method of cultivation.
Pengaruh Kegiatan Keagamaan Terhadap Karakter Religious Siswa di SMK Al Fattah Kalitidu Bojonegoro
Authors: Ibnu Habibi  
Published: October 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh Kegiatan Keagamaan Terhadap Karakter Religious Siswa di SMK Al Fattah Kalitidu Bojonegoro. Penelitian ini adalah penelitian kuantitatif .dengan menggunakan pendekatan metode diskriptif survey dengan populasi seluruh siswa SMK Al Fattah Kalitidu Bojonegoro yang berjumlah 118 siswa. adapun jenis sampling yang digunakan penelitian ini adalah sampling jenuh, dengan jumlah sampel 23 siswa. suber data dalam penelitian ini ada sumber data primer dan sekunder. Metode pengumpulan data pada penelitian ini menggunakan metode survey, observasi, metode dokumentasi, dan metode wawancara. Teknik analisis pada penelitian ini menggunakan rumus product moment. Hasil penelitian ini menujukkan bahwa Pengaruh Kegiatan Keagamaan Terhadap Karakter Religious Siswa di SMK Al Fattah Kalitidu Bojonegoro tergolong sangat baik karena terdapat 100 % siswa yang mendapat skor sanagat tinggi. Pembentukan karakter religious siswa di SMK Al Fattah Kalitidu Bojonegoro berada pada kategori cukup baik dengan hasil perhitungan mencapai 65,22%.. Berdasarkan dari uji product moment diperoleh kesimpulan bahwa ada pengaruh antara kegiatan keagamaan dengan pembentukan karakter religious siswa di SMK Al Fattah Kalitidu Bojonegoro. Hal ini dapat dibuktikan dengan nilai koefisiensi korelasi product moment yang didapat, yang mana r hitung 0,6414 lebih besar dari nilai r tabel 0,4130 dengan taraf signifikansi 5% dan berada dalam kategori sedang.
Using of virtual reality and artificial intelligence in education: literature review
Authors: Sadvakassova Aigul , Kydyrbekova Aliya , Chetin Oguz 
Published: October 2024

Many individuals believe that new technology has been a transformative force in the field of education. Various technologies have been integrated into educational process in order to identify its capacity of enhancing student-learning experience. According to the newest studies, some recently developed technologies such as artificial intelligence (AI) and virtual reality (VR) have the potential to significantly improve teaching and learning processes. The article considers the relevance of using virtual reality and artificial intelligence resources in education. With the help of systematic literature review, this article provides a cumulative meta-analysis of works of a number of scholars who examined the influence of application of VR and AI on student learning experience. The authors found that the advantages of integrating these technologies into educational process are based on the increase in students’ interests in the subject, the effectiveness in explaining complex topics, and the formation of a culture of openness to new technologies. The conclusions of the article contribute to the expansion of local academic understanding of this topic and are also useful for decision-makers in the field of secondary education and higher educational institutions which integrate educational technologies
Образовательные программы для персонификации непрерывного профессионального развития педагогов в условиях самоуправляемого обучения
Authors: Мурзалинова Алма , Ашимбетова Роза , Иманова Алия , Зейнелова Айгуль 
Published: October 2024

Содержание статьи отвечает исследованию, цель которого - создание системы непрерывного профессионального развития педагогов в аспекте образования для сложного мира. В статье представлены результаты исследования - научно-методические основы разработки образовательных программ курса актуального профессионального развития. Цель образовательных программ – развитие компетенций непрерывного профессионального развития посредством освоения стратегий саморазвития для самоуправления профессионально-личностным ростом в направлении устойчивого улучшения образовательной практики и карьерно-образовательного роста. В основу разработки положена идея персонификации обучения, реализуемая посредством индивидуального выбора обучающимися педагогами и освоения ими - во взаимодействии с тренерами и фасилитаторами курса - стратегий саморазвития, что позволяет адаптировать образовательный процесс к устранению профессиональных дефицитов посредством организуемых процессов профессионального развития. Апробация разработанных образовательных программ комплекса «Совершенствование через развитие» (для педагогов, педагогов-модераторов, педагогов-экспертов, педагоов-исследователей и педагогов-мастеров) позволяет сформулировать следующие выводы. Обучение стратегиям саморазвития эффективно в силу субъектности: освоение выбранных стратегий отвечает продвижению аттестуемых педагогов в образовательно-карьерной траектории. Такое обучение формирует самоуправляемых педагогов, способных самостоятельно определять цели, содержание и темп своего обучения, создавать востребованные в практике образовательные продукты, погружаться в различные образовательные опыты, обеспечивающие целостное развитие на основе метапознания и метакогнитивных навыков. Непрерывность профессионального развития обеспечивается практико-ориентированным обучением в контексте профессионально-педагогических условий через опыт и действие и обмен ими, а также в интеграции ресурсов формального, неформального и информального образования для реализации моделей обучения «lifelong learning», «lifewide learning», «lifedeep learning».
Ключевые слова: непрерывное профессионально-педагогическое развитие, персонификация профессионального развития, курс актуального профессионального развития, образовательная программа, стратегии саморазвития, самоуправляемые педагоги, индивидуальный выбор, фасилитаторы.
Análisis de la resiliencia y el clima motivacional en deportistas de combate y artes marciales
Authors: Ortiz-Franco Manuel , Lindell-Postigo David , Cachón-Zagalaz Javier , Zurita-Ortega Félix , Valdivia-Moral Pedro , Melguizo-Ibáñez Eduardo 
Published: October 2024

The relationship between motivational climate and resilience is of special interest in combat sports and martial arts practitioners due to the uniqueness of these sports modalities. This cross-sectional study was conducted in a population of 303 combat and martial arts athletes. The objective of this research is to analyze the relationships between motivational climate and resilience, using structural equation analysis. The main instruments used were the motivational climate (PMCSQ-2) and resilience (CD-RISC) questionnaires. A positive effect is observed between task climate and resilience; on the contrary, a negative effect is shown between resilience and ego climate and between ego climate and task climate. In conclusion, it is observed that the orientation of sports practice towards the task climate brings a benefit in the development of resilience in combat and martial arts athletes.
La relación entre la resiliencia y el clima motivacional es de especial interés en deportistas practicantes de artes marciales y deportes de combate por la singularidad de estas modalidades deportivas. Este estudio transversal se realizó en una población de 303 deportistas de combate y artes marciales. El estudio pretende analizar las relaciones entre la resiliencia y el clima motivacional, utilizando el análisis de ecuaciones estructurales. Los principales instrumentos utilizados fueron los cuestionarios sobre el clima motivacional (PMCSQ-2) y resiliencia (CD-RISC). Se observa un efecto positivo entre el clima tarea y la resiliencia; por el contrario, se muestra un efecto negativo entre la resiliencia y el clima ego, al igual que, entre el clima ego y clima tarea. En conclusión, se orientar la práctica deportiva hacia un clima centrado en la tarea conlleva beneficios para el desarrollo de la resiliencia en deportistas practicantes de deportes de combate y artes marciales.
A relação entre o clima motivacional e a resiliência é de especial interesse para os praticantes de desportos de combate e artes marciais devido à singularidade destas modalidades desportivas. Este estudo transversal foi realizado numa população de 303 atletas de desportos de combate e artes marciais. O objectivo desta investigação é analisar as relações entre o clima motivacional e a resiliência, utilizando a análise de equações estruturais. Os principais instrumentos utilizados foram os questionários de clima motivacional (PMCSQ-2) e de resiliência (CD-RISC). Observou-se um efeito positivo entre o clima da tarefa e a resiliência, enquanto um efeito negativo foi observado entre a resiliência e o clima do ego e entre o clima do ego e o clima da tarefa. Em conclusão, observa-se que a orientação da prática desportiva para o clima de tarefa tem um efeito benéfico no desenvolvimento da resiliência em atletas de combate e de artes marciais.