bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptability of linking individual credit, financial, and public records data to healthcare records for suicide risk machine learning models
Authors: Penfold Robert B , Yoo Hong Il , Richards Julie E , Crossnohere Norah L , Johnson Eric , Pabiniak Chester J , Renz Anne D , Campoamor Nicola B , Simon Gregory E , Bridges John F P 
Published: October 2024

Abstract

Objectives
Individual-level information about negative life events (NLE) such as bankruptcy, foreclosure, divorce, and criminal arrest might improve the accuracy of machine learning models for suicide risk prediction. Individual-level NLE data is routinely collected by vendors such as Equifax. However, little is known about the acceptability of linking this NLE data to healthcare data. Our objective was to assess preferences for linking external NLE data to healthcare records for suicide prevention.

Materials and Methods
We conducted a discrete choice experiment (DCE) among Kaiser Permanente Washington (KPWA) members. Patient partners assisted in the design and pretesting of the DCE survey. The DCE included 12 choice tasks involving 4 data linking program attributes and 3 levels within each attribute. We estimated latent class conditional logit models to derive preference weights.

Results
There were 743 participants. Willingness to link data varied by type of information to be linked, demographic characteristics, and experience with NLE. Overall, 65.1% of people were willing to link data and 34.9% were more private. Trust in KPWA to safeguard data was the strongest predictor of willingness to link data.

Discussion
Most respondents supported linking NLE data for suicide prevention. Contrary to expectations, People of Color and people who reported experience with NLEs were more likely to be willing to link their data.

Conclusions
A majority of participants were willing to have their credit and public records data linked to healthcare records provided that conditions are in place to protect privacy and autonomy.
Digital platforms and the reconfiguration of global production networks
Authors: Verfürth Philip , Helwing-Hentschel Veronique 
Published: October 2024

Abstract
Digital business-to-business (B2B) platforms have become essential components of today's economy. However, the impact of digital B2B platforms on global production networks has not yet been sufficiently conceptualized and empirically examined. This article proposes an analytical framework to theorize platform-based reconfigurations of global production networks. By using the case of digital logistics platforms, the article illustrates that service-centred platforms, in particular, have a major impact on global production networks, as they are able to position themselves as lead firms and to utilize data to shape the organizational and spatial composition of global production networks.
The Vicious Circle of Securitization Processes in the Former Indian State of Jammu and Kashmir
Authors: Constantin Sergiu , Carlà Andrea 
Published: October 2024

Abstract
This article analyzes processes of securitization in India’s former State of Jammu and Kashmir (SJK), a disputed borderland characterized by a three-dimensional conflict: the international conflict over Jammu and Kashmir, the inter-governmental conflict between the autonomous SJK and the Indian government, and the inter-communal conflict within the SJK. Applying the concept of securitization beyond its traditional Eurocentric perspective, we explore the securitization of transborder kinship in a case study outside the Global North. We examine the perceived threats vis-à-vis the SJK and the Kashmiri Muslim in light of ontological insecurities rooted in the main Indian national narratives and show how dysfunctional diversity governance in a complex geopolitical context intersects with processes of securitization, affecting inter-communal, inter-governmental, and inter-state relations. The article shows that ontological insecurities, combined with fear of separatism and short-sighted political strategies, led Indian political elites to erode the autonomy of the SJK, and undermine its democratic political processes. This, in turn, led to an increasing dissatisfaction among various communities and, in time, to civil unrest, strong religious polarization, communal and state violence, human rights abuses, insurgency, and the rise of separatist Islamic militant groups. This vicious circle turned New Delhi’s fears into a self-fulfilling prophecy. We highlight the continuum of securitization processes and argue that the former SJK could escape the vicious circle of securitization only through a combination of self-governance, good governance, and international governance.
DST regulates cisplatin resistance in colorectal cancer via PI3K/Akt pathway
Authors: Yu Jianwei , Deng Xueqiong , Lin Xueqin , Xie Li , Guo Sisi , Lin Xiaoliang , Lin Dong 
Published: October 2024

Abstract

Objectives
Dystonin (DST), a potential tumor suppressor gene, plays a crucial role in regulating cancer cell proliferation and resistance to chemotherapy. However, DST’s specific role in colorectal cancer (CRC) has not been thoroughly investigated, and this study aims to elucidate its molecular role in modulating cisplatin (DDP) resistance in CRC.

Methods
DST expression was analyzed in CRC tumors, DDP-resistant CRC tissues, paracancer tissues, and normal tissues. Lentiviral overexpression and shRNA knockdown were conducted in advanced CRC and DDP-resistant cell lines to assess cell viability, apoptosis, invasion, migration, proliferation, and angiogenesis. Xenograft mouse models studied DST’s impact on CRC tumor growth and DDP resistance in vivo.

Results
DST expression was significantly reduced in CRC tumor and DDP-resistant CRC tissues compared to paracancer and normal tissues (P &lt; .001). Upregulating DST inhibited CRC and DDP-resistant cell viability, proliferation, invasion, and migration while promoting apoptosis. DST overexpression also reduced angiogenesis and attenuated DDP-induced cytotoxicity in CRC cells. Mechanistically, DST upregulation suppressed DDP resistance in CRC cells via the PI3K/Akt signaling pathway. DST upregulation reduced CRC tumor growth and mitigated DDP resistance, in vivo.

Conclusion
DST plays a crucial role in limiting CRC progression and overcoming DDP resistance, suggesting potential for targeted CRC therapies.
On the nature of the eccentric eclipsing binary star SY Phe with a pulsating γ Dor component
Authors: Erdem Ahmet , Sürgit Derya , Engelbrecht Chris A , Zasche Petr , Bakış Volkan , Marang Fred 
Published: October 2024

ABSTRACT
Spectroscopic observations of the eccentric binary system SY Phe were made at the South African Astronomical Observatory in 2019, 2020, and 2021, and its mid-resolution spectra were obtained. The radial velocities of the component stars were measured using the cross-correlation method and Fourier disentangling of the spectra. The spectral type (hence the effective temperature) of the primary star was determined from a model-atmosphere analysis. The radial velocity and Transiting Exoplanet Survey Satellite (TESS) light curves of the system were analysed, and its absolute parameters were derived. A strong (5.2 mmag) periodic signal with a frequency typical of $\gamma$ Dor stars (1.169 cycles per day) dominates the Fourier spectrum of the light curve between the eclipses. Apsidal motion parameters of SY Phe were calculated by studying eclipse timing variations. The Geneva evolution models indicate an evolutionary age of 2 Gyr and solar metallicity for the primary component; however, although the position of the secondary component in the H–R diagram matches the isochrone of 2 Gyr, it appears to have a larger radius and higher effective temperature than expected for its determined mass. Here, the secondary component has too large a radius, which is in accordance with the radius discrepancy problem that has been encountered in other studies, especially in late-type dwarfs, and has not been solved for half a century.
MeerKAT observations of pair-plasma induced birefringence in the double pulsar eclipses
Authors: Lower M E , Kramer M , Johnston S , Breton R P , Wex N , Bailes M , Buchner S , Camilo F , Oswald L S , Reardon D J , Shannon R M , Serylak M , Krishnan V Venkatraman 
Published: October 2024

ABSTRACT
PSR J0737−3039A/B is unique among double neutron star systems. Its near-perfect edge-on orbit causes the fast spinning pulsar A to be eclipsed by the magnetic field of the slow spinning pulsar B. Using high-sensitivity MeerKAT radio observations combined with updated constraints on the system geometry, we studied the impact of these eclipses on the incident polarization properties of pulsar A. Averaging light curves together after correcting for the rotation of pulsar B revealed enormous amounts of circular polarization and rapid changes in the linear polarization position angle, which occur at phases where emission from pulsar A is partially transmitted through the magnetosphere of pulsar B. These behaviours confirm that the eclipse mechanism is the result of synchrotron absorption in a relativistic pair-plasma confined to the closed-field region of pulsar B’s truncated dipolar magnetic field. We demonstrate that changes in circular polarization handedness throughout the eclipses are directly tied to the average line of sight magnetic field direction of pulsar B, from which we unambiguously determine the complete magnetic and viewing geometry of the pulsar.
Interleukin-22 improves ovulation in polycystic ovary syndrome via STAT3 signaling
Authors: Liao Baoying , Chen Weixuan , Qi Xinyu , Yun Chuyu , Pang Yanli 
Published: October 2024

Abstract
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease, which leads to serious impairment of reproductive health in women of child-bearing age. Anovulation or oligo-ovulation is a common clinical manifestation of PCOS patients. A disturbance of the ovarian immune microenvironment contributes to the disorders of follicle development and ovulation; however, the underlying mechanism remains unclear. Here we demonstrated the protective effect of immune factor interleukin-22 (IL-22) on PCOS follicle development and ovulation. Follicular IL-22 levels were significantly lower in PCOS patients than in the control group and were positively correlated with oocyte fertilization rate and high-quality embryo rate. Additionally, IL-22 evidently improved follicle development in vitro and promoted ovulation-related gene expression, which was disrupted by the depletion of interleukin-22 receptor 1 (IL-22R1) or inhibition of STAT3 in granulosa cells. This indicates that IL-22 acts through IL-22R1 and the STAT3 signaling pathway to promote follicle development and ovulation in PCOS. In summary, this study has elucidated the vital role of the ovarian immune microenvironment in follicle development and ovulation. Application of IL-22 may provide new insights into the treatment of PCOS patients.
Do Personalized Nutrition Interventions Improve Dietary Intake and Risk Factors in Adults With Elevated Cardiovascular Disease Risk Factors? A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Cross Victoria , Stanford Jordan , Gómez-Martín María , Collins Clare E , Robertson Seaton , Clarke Erin D 
Published: October 2024

Abstract

Context
Dietary modifications can improve cardiovascular disease (CVD) risk factors. Personalized nutrition (PN) refers to individualized nutrition care based on genetic, phenotypic, medical, behavioral, and/or lifestyle characteristics. PN may be beneficial in improving CVD risk factors, including diet. However, this has not been reviewed previously.

Objective
The aim was to evaluate the effectiveness of PN interventions on CVD risk factors and diet in adults at elevated CVD risk.

Data Sources
Six databases were searched for randomized controlled trials published between 2000 and 2023 that tested the impact of PN interventions on CVD risk factors in people at elevated risk.

Data Extraction
Risk of bias was assessed using the Academy of Nutrition and Dietetics Quality Criteria checklist. Data synthesis of eligible articles included participant characteristics, intervention details, and change in primary CVD risk factor outcomes, including blood pressure (BP), plasma lipids, and CVD risk score, and secondary risk factors, including anthropometric outcomes and diet quality. Random-effects meta-analyses were conducted to explore weighted mean differences (WMDs) in change or final mean values for studies with comparable data (studies with dietary counseling interventions) for outcomes including BP, blood lipids, and anthropometric measurements.

Data Analysis
Of 7676 identified articles, 16 articles representing 15 studies met the inclusion criteria. Studies included between 40 and 563 participants and reported outcomes for CVD risk factors, including hyperlipidemia (n = 5), elevated BP (n = 3), overweight/obesity (n = 1), and multiple risk factors (n = 6). Risk of bias was low. Results suggested potential benefit of PN on systolic BP (WMD: −1.91; 95% CI: −3.51, −0.31 mmHg) and diastolic BP (WMD: −1.49; 95% CI: −2.39, −0.58 mmHg) and dietary intake in individuals at high CVD risk. Results were inconsistent for plasma lipid and anthropometric outcomes.

Conclusion
Results were promising for PN interventions that used dietary counseling on CVD risk factors in at-risk individuals. However, further evidence for other personalization methods is required, including improving methodological quality and longer study duration in future PN interventions.

Systematic Review Registration
OpenScience Framework (https://doi.org/10.17605/OSF.IO/SHVWP).
Validation of Cefiderocol Package Insert Dosing Recommendation for Patients Receiving Continuous Renal Replacement Therapy: A Prospective Multicenter Pharmacokinetic Study
Authors: Fouad Aliaa , Kobic Emir , Nicolasora Nelson P , Bastin Melissa L Thompson , Adams Paul M , Shen Yuwei , Fratoni Andrew J , Ye Xiaoyi , Kuti Joseph L , Nicolau David P , Asempa Tomefa E 
Published: October 2024

Abstract

Background
Cefiderocol is the first antibiotic with effluent flow rate–based dosing recommendations outlined in the product label for patients receiving continuous renal replacement therapy (CRRT). We aimed to investigate the population pharmacokinetics of cefiderocol among patients receiving CRRT and validate these dosing recommendations.

Methods
A multicenter, prospective cefiderocol pharmacokinetic study among intensive care unit patients receiving CRRT was conducted (2022–2023). Blood sampling was performed at steady-state and cefiderocol concentrations were assayed by validated liquid chromatography–tandem mass spectrometry. Population pharmacokinetic analyses were conducted in Pmetrics using R software. The free time above the minimum inhibitory concentration (f T &gt; MIC) and total daily area under the concentration time curve (AUCdaily) were calculated.

Results
Fourteen patients with effluent flow rates ranging from 2.1 to 5.1 L/h were enrolled. Cefiderocol concentrations best fitted a 2-compartment model. Mean ± standard deviation (SD) parameter estimates for clearance, central compartment volume, and intercompartment transfer constants (k12 and k21) were 3.5 ± 1.5 L/hour, 10.7 ± 8.4 L, 3.9 ± 1.8 hours−1, and 2.2 ± 2.2 hours−1, respectively. With simulations based on product label dosing recommendations, all patients achieved 100% fT &gt; MIC up to MIC 8 mg/L with an AUCdaily (mean ± SD) of 1444 ± 423 mg × hour/L. Cefiderocol was well tolerated among the 14 patients.

Conclusions
The current package insert dosing recommendations resulted in pharmacodynamically optimized cefiderocol exposures. Cefiderocol concentrations exceeded relevant MIC breakpoints in all patients at each effluent flow rate, and AUCdaily was within the range observed in patients in the phase 3 clinical trials, suggestive of a safe and therapeutic drug profile.
A world of evidence: the global spread and silent politics of evidence cultures
Authors: Straßheim Holger 
Published: October 2024

Abstract
How can we explain the worldwide spread of evidence-based policymaking despite continuous criticism? What are the underlying mechanisms of its persistence on a global scale? This article aims at answering these questions by focusing on the cultural constellations in which evidence is imbued with political as well as epistemic authority. Evidence cultures are discursive and institutional forces (re-)producing both the scientific validation of knowledge and its relevance in policymaking. They need to be understood as self-propagating constellations of interlinking science and policy through practices, discourses and institutionally sedimented regulations. Evidence is the product of chains of practices in which the initial knowledge struggles are gradually made publicly invisible and often inaccessible. The article reconstructs the immunization of evidence cultures from criticism and their silent politics by looking at quantifications, benchmarking and randomized controlled trials as typical cases. To overcome the circularities and closures so characteristic of the evidence culture of evidence-based policymaking, politico-epistemic diversity should be actively promoted.
Thermophysical Properties and Mass Spectra of Meson Systems via the Nikiforov–Uvarov Method
Authors: Horchani Ridha , Al Kharusi Omama , Ikot Akpan N , Ahmed Faizuddin 
Published: October 2024

Abstract
In this study, we analyze the mass spectra of meson systems within an N-dimensional space using the Killingbeck potential combined with an inversely quadratic potential. We employ the Nikiforov–Uvarov method along with the Pekeris approximation scheme to account for the centrifugal barrier. This approach enables us to compute numerical energy eigenvalues, normalized eigenfunctions, and mass spectra for both heavy and heavy–light meson systems. We explore various scenarios of the potential and find that the resulting energy eigenvalues are consistent with those obtained through previous analytical methods and experimental data. Additionally, we compute the thermodynamic properties of quarkonium particles, including mean energy, specific heat, free energy, and entropy. Furthermore, we investigate the effects of temperature and the dimensional number on meson masses and thermodynamic properties, providing valuable insights into the behavior of meson systems under different conditions.
Determinants of Longitudinal Changes in Exercise Capacity in Patients With Independent Functioning on Hemodialysis
Authors: Usui Naoto , Nakata Junichiro , Uehata Akimi , Kojima Sho , Hisadome Hideki , Inatsu Akihito , Tsubaki Atsuhiro , Saitoh Masakazu , Ando Shuji , Kitayama Tatsuro , Maikusa Kenta , Nishiyama Yuki , Suzuki Yusuke 
Published: October 2024

Abstract

Objective
Patients with chronic kidney disease reportedly have decreased muscle oxygen utilization, which most substantially decreases exercise capacity, followed by cardiac reserve. However, determinants of longitudinal changes in exercise capacity in patients on hemodialysis (HD) and the effects of long-term exercise interventions (EI) are unknown. This study was conducted to clarify these concerns.

Methods
This was a prospective cohort study. Patients on HD that were not hospitalized were followed from baseline up to 2 years, and cardiopulmonary exercise testing results, including peak oxygen uptake, peak work rate, heart rate reserve, and ventilatory equivalent for carbon dioxide slope, as well as implementation of EI were assessed. Based on the 2-year change in peak oxygen uptake, they were divided into improvement or declined groups.

Results
Forty-five patients who were not hospitalized completed the follow-up were analyzed. In the improvement group, the variation was determined by an increase in peak work rate, which is a peripheral factor (partial regression coefficient 0.08 [95% CI = 0.01 to 0.16]), while in the decline group, the variation was determined by a decrease in the ventilatory equivalent for carbon dioxide slope, which is a cardiac factor (partial regression coefficient = −0.12; 95% CI = −0.21 to −0.03). Moreover, exercise intervention was associated with the change in peak oxygen uptake (partial regression coefficient = 3.09; 95% CI = 1.45 to 4.72).

Conclusion
Exercise intolerance even in patients on HD that were not hospitalized and stable progressed over time with deterioration of cardiac reserve, whereas EI were associated with improved exercise capacity through enhanced peripheral function.

Impact
The results support the early measurement of cardiopulmonary or skeletal muscle reserve through cardiopulmonary exercise testing and the implementation of long-term EI based on the measurement results to address the potential deterioration in exercise capacity associated with reduced cardiac reserve, even in patients on HD that are asymptomatic and stable.
Deucravacitinib, a selective, TYK2 inhibitor, in psoriatic arthritis: achievement of minimal disease activity components in a phase 2 trial
Authors: Kavanaugh Arthur , Coates Laura C , Mease Philip J , Nowak Miroslawa , Hippeli Lauren , Lehman Thomas , Banerjee Subhashis , Merola Joseph F 
Published: October 2024

Abstract

Objectives
Deucravacitinib is a novel, oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor belonging to a distinct class of enzyme inhibitors. In a phase 2 trial in psoriatic arthritis (NCT03881059), deucravacitinib was significantly more efficacious than placebo across multiple endpoints, including achieving minimal disease activity (MDA). This post hoc analysis further evaluated the achievement of individual components of the MDA criteria with deucravacitinib treatment and the time course of responses in the phase 2 trial.

Methods
Patients (N = 203) were randomized 1:1:1 to once daily treatment with placebo, deucravacitinib 6 mg or deucravacitinib 12 mg. The proportions of patients achieving MDA and each of the seven individual MDA components through week 16 were assessed.

Results
At baseline, although some patients met criteria for individual MDA components, none of the patients met the composite MDA criterion, and all components were balanced overall across treatment arms. Treatment with deucravacitinib was associated with a numerically greater mean reduction from baseline in all MDA components vs placebo over 16 weeks of treatment. At week 16, a greater percentage of patients treated with either dose of deucravacitinib vs placebo achieved the threshold criteria for meeting MDA in each of the components.

Conclusions
More patients treated with deucravacitinib met each of the MDA components vs placebo, along with a higher rate of MDA response, after 16 weeks of treatment.