bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Antifouling and Bactericidal Coatings for Platelet Storage Bags Using Dopamine Chemistry
Authors: Hadjesfandiari Narges , Weinhart Marie , Kizhakkedathu Jayachandran N. , Haag Rainer , Brooks Donald E. 
Published: September 2017

AbstractPlatelets have a limited shelf life, due to the risk of bacterial contamination and platelet quality loss. Most platelet storage bags are made of a mixture of polyvinyl chloride with a plasticizer, denoted as pPVC. To improve biocompatibility of pPVC with platelets and to inhibit bacterial biofilm formation, an antifouling polymer coating is developed using mussel‐inspired chemistry. A copolymer of N,N‐dimethylacrylamide and N‐(3‐aminopropyl)methacrylamide hydrochloride is synthesized and coupled with catechol groups, named DA51‐cat. Under mild aqueous conditions, pPVC is first equilibrated with an anchoring polydopamine layer, followed by a DA51‐cat layer. Measurements show this coating decreases fibrinogen adsorption to 5% of the control surfaces. One‐step coating with DA51‐cat does not coat pPVC efficiently although it is sufficient for coating silicon wafers and gold substrates. The dual layer coating on platelet bags resists bacterial biofilm formation and considerably decreases platelet adhesion. A cationic antimicrobial peptide, E6, is conjugated to DA51‐cat then coated on silicon wafers and introduces bactericidal activity to these surfaces. Time‐of‐flight second ion‐mass spectroscopy is successfully applied to characterize these surfaces. pPVC is widely used in medical devices; this method provides an approach to controlling biofouling and bacterial growth on it without elaborate surface modification procedures.
Solid‐State Explosive Reaction for Nanoporous Bulk Thermoelectric Materials
Authors: Zhao Kunpeng , Duan Haozhi , Raghavendra Nunna , Qiu Pengfei , Zeng Yi , Zhang Wenqing , Yang Jihui , Shi Xun , Chen Lidong 
Published: September 2017

AbstractHigh‐performance thermoelectric materials require ultralow lattice thermal conductivity typically through either shortening the phonon mean free path or reducing the specific heat. Beyond these two approaches, a new unique, simple, yet ultrafast solid‐state explosive reaction is proposed to fabricate nanoporous bulk thermoelectric materials with well‐controlled pore sizes and distributions to suppress thermal conductivity. By investigating a wide variety of functional materials, general criteria for solid‐state explosive reactions are built upon both thermodynamics and kinetics, and then successfully used to tailor material's microstructures and porosity. A drastic decrease in lattice thermal conductivity down below the minimum value of the fully densified materials and enhancement in thermoelectric figure of merit are achieved in porous bulk materials. This work demonstrates that controlling materials' porosity is a very effective strategy and is easy to be combined with other approaches for optimizing thermoelectric performance.
Fluorescent Humidity Sensors Based on Photonic Resonators
Authors: Szendrei Katalin , Jiménez‐Solano Alberto , Lozano Gabriel , Lotsch Bettina V. , Míguez Hernán 
Published: September 2017

AbstractAmong the different approaches to humidity sensing available, those based on fluorescent signals are gathering a great deal of attention due to their fast response and versatility of detection and design. So far, all proposals have focused on the use of luminescent probes whose emission is either triggered or inhibited by the presence of water that reacts or alters their chemical environment, hence inducing the signal change. Here, a novel concept in fluorescent humidity sensing based on combining stimuli‐responsive photonic resonators with molecular fluorescent probes is introduced. The resonator is assembled from humidity‐swellable antimony phosphate nanosheets embedding a planar light‐emitting probe, whose emission is dramatically modified by the changes that ambient humidity causes in its photonic environment. Guided by “in silico” optical design of the resonator architecture and subsequent experimental realization, two embodiments of fluorescent photonic humidity sensors featuring turn‐on and turn‐off detection schemes are presented. The interplay between the luminescent properties of an emitter and its photonic environment implies a fundamental advantage as the emitters are not chemically altered during the detection process. At the same time, it paves the way toward a new generation of photonic humidity sensors which can conveniently be interfaced with common fluorescence detection schemes.
Zirconia‐Supported Cu(I)‐Stabilized Copper Oxide Mesoporous Catalyst for the Synthesis of Quinazolinones Under Ambient Conditions
Authors: Parashuram L. , Sreenivasa Swamy , Akshatha S. , Kumar V. Udaya , Kumar Sandeep 
Published: September 2017

AbstractAlthough there are many reports on the synthesis of quinazolinones, the use of high boiling solvents and high temperature restricts their scale‐up to the industrial level. The current research reveals a simple protocol for the catalytic synthesis of quinazolines in the presence of a cost‐effective and reusable mesoporous ZrO2‐supported Cu2O (Cu2ZrO3) catalyst. The catalyst was prepared by simple co‐precipitation and characterized using techniques like XRD, TGA, BET, SEM and TEM. The catalyst was reused for five cycles without significant loss in the activity and the catalyst was truly heterogeneous. The present synthesis utilizes environmentally benign H2O2 as an oxidant. The present protocol showed good tolerance for various substituted aldehydes and good yields for quinazolinone derivatives. The method followed a simple workup procedure and no column chromatography was needed.
Ferroelasticity in an Organic Crystal: A Macroscopic and Molecular Level Study
Authors: Mir Sajjad Husain , Takasaki Yuichi , Engel Emile Richard , Takamizawa Satoshi 
Published: September 2017

AbstractFerroelasticity has been relatively well‐studied in mechanically robust inorganic atomic solids but poorly investigated in organic crystals, which are typically inherently fragile. The absence of precise methods for the mechanical analysis of small crystals has, no doubt, impeded research on organic ferroelasticity. The first example of ferroelasticity in an organic molecular crystal of 5‐chloro‐2‐nitroaniline is presented, with thorough characterization by macro‐ and microscopic methods. The observed cyclic stress–strain curve satisfies the requirements of ferroelasticity. Single‐crystal X‐ray structure analysis provides insight into lattice correspondence at the twining interface, which enables substantial crystal bending by a large molecular orientational shift. This deformation represents the highest maximum strain (115.9 %) among reported twinning materials, and the associated dissipated energy density of 216 kJ m−3is relatively large, which suggests that this material is potentially useful as a mechanical damping agent.
Enantioselective Total Synthesis of 3β‐Hydroxy‐7β‐kemp‐8(9)‐en‐6‐one, a Diterpene Isolated from Higher Termites
Authors: Wang Yuzhou , Jäger Anne , Gruner Margit , Lübken Tilo , Metz Peter 
Published: September 2017

AbstractThe first total synthesis of the title diterpene was accomplished starting from the Wieland–Miescher ketone. A diastereoselective sulfa‐Michael addition enabled the generation of the delicate β,γ‐unsaturated ketone moiety, while the tetracyclic kempane skeleton was readily constructed through domino metathesis.
Poly(lactic acid)/areca fiber laminate composites processed via film stacking technique
Authors: Kousaalya Adhimoolam Bakthavachalam , Biddappa Bopaiah Ittira , Krumm Kelly , Pradeep Sai Aditya , Pilla Srikanth 
Published: September 2017

ABSTRACTBio‐based laminate composites, consisting of alternatively stacked poly(lactic acid) (PLA) sheet and randomly oriented areca fiber mat, were processed via film stacking technique (FST). FST was chosen as it is a commercially viable, low energy‐intensive process for fabricating fiber‐reinforced composite, thereby advocating environmental sustainability. Laminate composites exhibited mechanical strength of 6.5 MPa at 16 wt % fiber loading. Crystallinity of as‐received PLA sheets was found to be 26% due to the presence of ∼30 wt % inorganic filler, and showed further enhancement to 50% upon the addition of 22 wt % areca fiber. Dynamic mechanical analysis showed higher glass transition temperature (83 °C) for PLA sheets, mainly due to the presence of higher filler content. This work demonstrates the use of bio‐based laminate composite processed at the lowest possible temperatures as viable alternatives to thermoplastic polyolefins in automobiles. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45795.
Physicochemical properties and antimicrobial activity of biocompatible carboxymethylcellulose‐silver nanoparticle hybrids for wound dressing and epidermal repair
Authors: Capanema Nádia S. V. , Mansur Alexandra A. P. , Carvalho Sandhra M. , Mansur Lorena L. , Ramos Carolina P. , Lage Andrey P. , Mansur Herman S. 
Published: September 2017

ABSTRACTSkin loss can be caused by accident, burn, trauma, chronic wounds, and diseases, which is severely aggravated by multidrug‐resistant bacterial infections. Soft hybrids based on biopolymers combined with silver nanoparticles (AgNPs) have potential applications as wound dressing supports and skin tissue repair. Thus, our study focused on the design, green synthesis, and comprehensive characterization of carboxymethyl cellulose (CMC–AgNP) nanocomposites for producing hydrogel membranes, with tunable physicochemical properties, cytocompatibility, and biocidal activity for potential application as wound dressing and skin repair. These nanocomposites were prepared using CMC with two degrees of carboxymethylation, distinct concentrations of citric acid (CA) crosslinker, and AgNPs by in situ chemical reduction, forming hybrid membranes by the solvent casting method. The results demonstrated that superabsorbent hydrogels were produced with swelling and degradation behaviors dependent on the concentration of CA crosslinker, degree of carboxymethylation of CMC, and content of AgNP in the matrices. Moreover, the Fourier transform infrared spectroscopy analysis evidenced that the CMC functional groups (e.g., COOH and OH) were directly involved in the chemical reactions for the formation of AgNPs and hydrogel crosslinking pathway. These nanocomposites were cytocompatible using in vitro 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyltetrazolium bromide cell viability assay with of human embryonic kidney cells. Conclusively, the CMC–AgNP nanohybrids demonstrated to be simultaneously non‐toxic combined with highly effective antibacterial activity against gram‐positive multi‐resistant wound/skin pathogens (Staphylococcus aureus) and moderate effect towards gram‐negative strains (Escherichia coli and Pseudomonas aeruginosa). © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45812.
Chronic cluster‐like headache in a patient with a macroprolactinoma presenting with falsely low prolactin levels: bromocriptine versus cabergoline?
Authors: Pineyro Maria M. , Sosa Gabriela , Finozzi Maria R. , Stecker Natalia , Pisabarro Raul , Belzarena Maria C. 
Published: September 2017

Key Clinical MessageCluster‐like headache may be associated with pituitary tumors, mostly prolactinomas. Pituitary imaging and prolactin measurement should be assessed in patients presenting with cluster‐like headaches with atypical features or unsatisfactory response to treatment. Furthermore, large pituitary adenomas with moderate increase in prolactin levels should prompt prolactin dilutions to avoid “hook effect”.
Regularization and selection in Gaussian mixture of autoregressive models
Authors: Khalili Abbas , Chen Jiahua , Stephens David A. 
Published: September 2017

AbstractGaussian mixtures of autoregressive models can be adopted to explain heterogeneous behaviour in mean, volatility, and multi‐modality of the conditional or marginal distributions of time series. One important task is to infer the number of autoregressive regimes and the autoregressive orders. Information‐theoretic criteria such asaicorbicare commonly used for such inference, and typically evaluate each regime/autoregressive combination separately in order to choose an optimal model. However the number of combinations can be so large that such an approach is computationally infeasible. In this article we first develop a computationally efficient regularization method for simultaneous autoregressive‐order and parameter estimation when the number of autoregressive regimes is pre‐determined. We then propose a regularized Bayesian information criterion (rbic) to select the number of regimes. We study asymptotic properties of the proposed methods, and investigate their finite sample performance via simulations. We show that asymptotically therbicdoes not underestimate the number of autoregressive regimes, and provide a discussion on the current challenges in investigating whether and under what conditions therbicprovides a consistent estimator of the number of regimes. We finally analyze U.S. gross domestic product growth and unemployment rate data to demonstrate the proposed methods.The Canadian Journal of Statistics45: 356–374; 2017 © 2017 Statistical Society of Canada
A nonparametric hypothesis test for heteroscedasticity in multiple regression
Authors: Zambom Adriano Z. , Kim Seonjin 
Published: September 2017

AbstractThis article presents a new method to test for heteroscedasticity in a general multiple nonparametric regression model. The test statistic is based on a high‐dimensional one‐way ANOVA constructed with the absolute value of the residuals, and its asymptotic distribution is derived under the null hypothesis of homoscedasticity and local alternative. The properties of the proposed test statistic are preserved when a correctly specified parametric mean function is used to obtain the residuals. Unlike most methods in the literature no parametric form is required for the multivariate variance function. Extensive simulations suggest that the proposed test detects heteroscedasticity in all models considered while classical methods fail in some cases. Two real data applications are examined.The Canadian Journal of Statistics45: 425–441; 2017 © 2017 Statistical Society of Canada
Mitochondria‐Targeting Polyamine–Protoporphyrin Conjugates for Photodynamic Therapy
Authors: Taba Fargol , Onoda Akira , Hasegawa Urara , Enoki Toshiaki , Ooyama Yousuke , Ohshita Joji , Hayashi Takashi 
Published: September 2017

AbstractTwo polyamine derivatives of protoporphyrin IX (PPIX) were tested as photodynamic therapy (PDT) agents in HT29 colorectal cancer and HEP3B liver cancer cell lines. These compounds exhibit excellent singlet oxygen quantum yields and show strong in vitro PDT efficacy after 660 nm laser irradiation, whereas exogenous PPIX itself exhibits much weaker PDT effects. Confocal microscopy imaging studies reveal that a protoporphyrin derivative with eight amine moieties has excellent water solubility, and localizes mainly in the mitochondria of both HT29 and HEP3B cells, whereas the cellular distribution of a protoporphyrin derivative with four amine moieties is not as specific. This work demonstrates that polyamine moieties on macrocycles can enhance PDT efficacy by targeting mitochondria.
Electrochemical Detection of Para‐nitrophenol using Copper Metal Nanoparticles Modified Gold Electrode
Authors: Barman Koushik , Changmai Bishwajit , Jasimuddin Sk 
Published: September 2017

Abstractpara‐Nitrophenol (p‐NP) is a high priority environmental pollutant. For the sake of safety, sensitive detection of its presence in water resources and food is highly important. The present article describes the use of copper metal nanoparticles for selective and sensitive electrochemical detection of p‐NP in pure and real sample. For this the gold electrode was fabricated by polyvenylpyrrolidone stabilized copper metal nanoparticles (ca. 4 nm d.) via self‐assembled 4,4′‐bipyridine monolayer and characterized by microscopic and electrochemical techniques. The newly developed sensor permits for sensitive detection of p‐NP in a linear concentration range of 1–500 μM with lowest detection limit of 0.34 nM and high sensitivities 247.1 μA cm−2 μM−1. The sensor electrode exhibited high stability, reproducibility, good selectivity in the presence of potential interfering agents and had an excellent capability for the selective determination of p‐NP in river water without preliminary treatments.
New hydroxyapatite nanophases with enhanced osteogenic and anti‐bacterial activity
Authors: Ballardini A. , Montesi M. , Panseri S. , Vandini A. , Balboni P. G. , Tampieri A. , Sprio S. 
Published: September 2017

AbstractThis work describes the synthesis and characterization of new apatite phases co‐doped with gallium, magnesium and carbonate, exhibiting osteogenic and antibacterial ability. The apatites are synthesized at low temperature to retain nanocrystallinity and controlled doping with the various bioactive foreign ions, as assessed by physico–chemical and crystallographic analyses, reporting the achievement of single phases with reduced crystal ordering. The analysis of single and multi‐doped apatites reports to different mechanisms acting in the incorporation of gallium and magnesium ions in the apatite structure. The release of bioactive ions is correlated to the behavior of human mesenchymal stem cells and of different bacterial strands, selected among the most frequently affecting surgical procedures. Enhanced osteogenic and antibacterial ability is assessed in multi‐doped apatites, thus suggesting potential future applications as new smart biomaterials integrating a significant boosting of bone regeneration with adequate protection against bacteria. © 2017 Wiley Periodicals Inc. J Biomed Mater Res Part A: 106A: 521–530, 2018.
Article Alerts: Items from 2012
Authors: Hafdahl Adam R. 
Published: September 2017

This seventh installment of “Article Alerts” includes a print component with 200 methodological articles about research synthesis published in 2012. More than 800 dissertations and theses have been added to the archive component since the preceding installment. Also since that installment, the parent compilation from which the print and archive components are built has more than doubled and now contains nearly 26 000 items.
Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic‐Ischemic Encephalopathy
Authors: Peeples Eric S. , Ezeokeke Chikodinaka K. , Juul Sandra E. , Mourad Pierre D. 
Published: September 2017

ObjectivesTo compare ultrasound‐derived resistive indices (RIs) obtained at the level of the thalamus via fast Doppler ultrasound with traditional anterior cerebral artery measures in a model of neonatal hypoxic‐ischemic encephalopathy and to correlate each with clinical outcomes.MethodsNine nonhuman primate neonates underwent no umbilical cord occlusion (n = 3), umbilical cord occlusion without hypothermia (n = 3), or umbilical cord occlusion with hypothermia (n = 3). The RI was measured in the anterior cerebral artery and thalamus on days 0, 1, and 4 of life. Magnetic resonance imaging with spectroscopy was performed on day 4.ResultsMean thalamus and anterior cerebral artery RI values in the first 36 hours of life were statistically different in neonates who died (+0.13; P = .019) or developed cerebral palsy (−0.08; P = .003). Thalamic RI values showed stronger associations with serum and spectroscopic lactate values than those in the anterior cerebral artery. The umbilical cord occlusion‐with‐hypothermia group showed a significant increase in the RI in the thalamus but not the anterior cerebral artery.ConclusionsResistive index measurements in the thalamus may eventually supplement other bedside measures for predicting outcomes in the HIE population, but further studies need to differentiate the effect of hypothermia from illness severity on thalamic perfusion.
Effects of rotational grazing management on nesting greater sage‐grouse
Authors: Smith Joseph T. , Tack Jason D. , Berkeley Lorelle I. , Szczypinski Mark , Naugle David E. 
Published: September 2017

ABSTRACTGrazing by domestic livestock is a ubiquitous land use in the sagebrush (Artemisia spp.) biome of western North America. Widespread, long‐term population declines in greater sage‐grouse (Centrocercus urophasianus) have elicited concern about potential negative effects of livestock management practices on sage‐grouse populations. We evaluated how recently implemented rotational grazing systems affected sage‐grouse nesting habitat quality as part of a large‐scale, replicated, natural experiment in central Montana, USA. We used Bayesian methods to assess support for effects of rotational grazing management and rest from grazing on daily survival rates of nearly 500 sage‐grouse nests monitored over 6 years, and mixed effects models to test for effects of rotational grazing and rest on vegetation structure. Though nests on rotationally grazed ranches displayed a trend toward greater daily survival rates, the evidence for an effect was weak. There was no evidence that rest from grazing (≥12 months) increased daily survival rates. Furthermore, rotational grazing systems and rest had negligible effects on herbaceous vegetation height and cover relative to other grazing strategies used in the study area. Results do not support the hypothesis that rotational grazing systems or rest from grazing increase nest success in the northern Great Plains. Estimated nest success, however, was comparable to range‐wide averages, suggesting concealing cover for nests is unlikely to be limiting growth of this population regardless of grazing strategy. In light of these results and recent research questioning reported relationships between grass height and nest survival, maximization of hiding cover may be overemphasized in grazing management guidelines and policies. Rather, our findings suggest a variety of locally appropriate grazing strategies focused on fundamental range health principles may provide adequate habitat quality for nesting sage‐grouse. © 2017 The Wildlife Society.
A methodology for assessing deployment trauma and its consequences in OEF/OIF/OND veterans: The TRACTS longitudinal prospective cohort study
Authors: McGlinchey Regina E. , Milberg William P. , Fonda Jennifer R. , Fortier Catherine Brawn 
Published: September 2017

AbstractMany US veterans of Afghanistan and Iraq have multiple physical and psychiatric problems. A major focus of research has been on determining the effects of mild Traumatic Brain Injury (mTBI), but mTBI is rarely diagnosed in the absence of co‐occurring conditions such as blast exposure, post‐traumatic stress disorder (PTSD), depression, substance abuse, etc. These potentially interactive psychological and physical conditions produce complex patterns of cognitive, psychological, and physical symptoms that impede civilian reintegration and complicate efficient and effective treatment planning. The Translational Research Center for TBI and Stress Disorders (TRACTS) has developed a multidisciplinary approach to the assessment of deployment trauma and its consequences in veterans of these wars. The prospective TRACTS longitudinal cohort study conducts state‐of‐the‐art assessments in the domains of biomedical function, lifetime head trauma, psychological function encompassing deployment experience and lifetime exposure to traumatic events, neuropsychological function, and structural and functional neuroimaging. The TRACTS longitudinal cohort study is the first of its kind to comprehensively evaluate lifetime incidence of TBI and PTSD in these veterans, in addition to those incurred during military deployment. The protocol has begun to reveal information that will help improve understanding of the complex pathophysiology associated with co‐occurring mTBI and related stress disorders.