bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of health portal enrolment with email reminders at an academic rheumatology clinic
Authors: Mendel Arielle , Chow Shirley 
Published: March 2017

Missed appointments reduce the quality, safety and efficiency of healthcare delivery. ‘No-Shows’ (NS) have been identified as a problem within the rheumatology clinic at Sunnybrook Health Sciences Center in Toronto, Ontario.NS were studied through a prospective chart review and telephone interviews. Over 6 months, 110 NS took place (rate 2.5-6.8%). From interviews, 85% of NS were attributed to forgetting, being unaware of the appointment, having the wrong date, or another miscommunication. Fifty-seven percent of patients were interested in an appointment reminder, including electronic reminders (46%).Patients were encouraged to enroll in the hospital's electronic patient portal, MyChart, and email reminders were implemented at one clinic for portal users. A detailed follow-up card was also given to patients. Process measures included portal enrolment, email reminder receipt, and call volumes. Outcome measures were NS and patient and staff satisfaction.During the intervention, 120/274 (44%) surveyed patients had MyChart accounts. Of these, 73 (61%) received the e-mail reminder and 72 (99%) found the e-mail helpful. Twenty-two patients knew about their appointment from the e-mail reminder alone. Improvement in attendance was seen after 3.5 months, but it was not sustained thereafter.Prior to this intervention there was no appointment reminder system at this clinic, and the email reminder demonstrated high patient satisfaction. Low portal enrolment, technical difficulties, and the inability of the intervention to reach new patients were possible reasons why the intervention was unsuccessful at reducing NS.
CCR5+ CD8 T-cell levels and monocyte activation precede the onset of acute coronary syndrome in HIV-infected patients on antiretroviral therapy
Authors: Tarancon-Diez Laura , De Pablo-Bernal Rebeca S. , Alvarez-Ríos Ana I. , Rosado-Sánchez Isaac , Dominguez-Molina Beatriz , Genebat Miguel , Pacheco Yolanda M. , Jiménez José Luis , Ángeles Muñoz-Fernández M. , Ruiz-Mateos Ezequiel , Leal Manuel 
Published: March 2017

SummaryAcute coronary syndrome (ACS) is nowadays one of the leading causes of morbid-mortality in HIV-infected population, but innate and adaptive immune mechanisms preceding this event are unknown. In this work we comprehensively and longitudinally observed, by multi-parametric flow cytometry and following a case-control design, increased CCR5+CD8+ T-cells levels and monocytes expressing activation and adhesion markers in HIV-infected patients who are going to suffer ACS. In addition, we found direct associations between activated CD8+ T-cells and myeloid cells that were only statistically significant in the group of patients with ACS and in the follow up time point just before the ACS. Our data highlight the important role of CCR5 in the onset of ACS and suggest this receptor as a marker of cardiovascular risk and potential therapeutic target to prevent the development of such non-AIDS-related event in HIV-infected patients.Note: This work was presented at the CROI 2016 conference (Boston, USA in February 2016).
The role of RNA uptake in platelet heterogeneity
Authors: Beaulieu Lea , Tanriverdi Kahraman , Freedman Jane , Clancy Lauren 
Published: March 2017

SummaryThe role of platelets in regulating vascular homeostasis has expanded beyond mediation of haemostasis and thrombosis. The discovery of platelet RNA and the presence of subpopulations of platelets containing varying amounts of RNA suggest a role for platelet transcripts in vascular function. As the RNA in anucleated platelets is biologically functional and may transfer to other vascular cells, we hypothesised that platelet RNA diminishes over the lifespan of the platelet with diminishing platelet size due to horizontal cellular transfer. The purpose of this study is to determine if platelet RNA variance is the result of horizontal cellular transfer between platelets and other vascular cells. Utilising platelet sorting and RNA sequencing, we found that smaller platelets contained a more diverse set of transcripts than larger platelets. Further investigation using fluorescence imaging, gene expression analyses and in vitro and in vivo modelling revealed that platelets take up RNA from other vascular cells in a complex manner, revealing a dynamic role for platelets in modulating vascular homeostasis through bidirectional RNA transfer. The resultant RNA profile heterogeneity suggests unique functional roles for platelets dependent on size and complexity. This study expands our basic understanding of platelet function and heterogeneity and is the first to evaluate endogenous vascular RNA uptake and its relation to platelet processes. Our findings describe a novel endogenous phenomenon that can help elucidate the platelet’s role in these non-thrombotic and haemostatic fields, as well as present potential for diagnostic and therapeutic development.Supplementary Material to this article is available online at www.thrombosis-online.com.
Meroscolex marcussi, sp. n., Oligochaeta, Glossoscolecidae da Amazônia
Authors: Righi Gilberto , Ayres Ione 
Published: March 2017

O presente estudo baseia-se em 18 animais coletados por um de nós (I. Ayres) em duas localidades do estado do Amazonas como segue:1 Estrada Manaus-Caracarai (BR-174), km 38, solo arenoso, 10 exemplares(5 clitelados), IX-XI/1974 (P I .N .P .A . 8-10).2. Estrada Manaus-Itacoatiara, km 80, Rio Preto de Eva, 8 exemplares(1 clitelado), XI/1974 ( P . I .N P.A. 11-12).Os animais foram fixados em formalina 10% e os cortes corados pela Hematoxilina de Ehrlich-Eosina. Os exemplares encontram-se depositados no Instituto Nacional de Pesquisas da Amazônia, Laboratório de Pedobiologia (P . I .N . P .A .).
Anatomy of the Nauplii of Oithona ovalis Herbst (Copepoda, Cyclopoida)
Authors: Fanta Edith Susana 
Published: March 2017

Foram estudados 6 estágios naupliares do ciclopóide Oithona ovalis Herbst 1955obtidos na n atureza ou criados em laboratório.Os náuplios vivos e as preparações histológicas foram observadas e descritas,a anatomia interna, o funcionamento de alguns órgãos e as mudanças que ocorreram durante o desenvolvimento naupliar. Atenção especial foi dispensada à musculatura e ao aparelho digestivo.
Caracterização macroscópica das gônadas do Curimbatá, Prochilodus scrofa (Steindachner, 1881), durante o ciclo reprodutivo
Authors: Alexandrino Agar Costa , Phan Mikico Tokumaru , Pinheiro Elza Ferreira Goldman 
Published: March 2017

Objetivando identificar as alterações cíclicas macroscópicas e microscópicas das gônadas, foram utilizados exemplares adultos (80 machos e 80 fêmeas) capturados no Rio Moji-Guaçu, Piraçununga-SP, no período de novembro de 1979 a fevereiro de 1981. As gônadas foram caracterizadas macroscópicamente quanto à vascularização superficial, coloração e volume e nas fêmeas a presença de óvulos visíveis. A seguir foram retiradas e amostradas em seu terço mêdio, o qual foi fixado em Bouin seguindo posteriormente técnicas histológicas de rotina. Os resultados obtidos para machos foram: repouso: gônada filiforme, rósea, com delicados vasos sanguíneos; microscopicamente os testículos mostram predominância de espermatogônias; maturação: a gônada aumenta de volume, coloraçao branco-leitosa, aumenta a vascularização superficial; microscopicamente predominam espermatócitos e espermátides; maduro: a gônada ocupa quase toda a cavidade abdominal, coloração branco-rosado; microscopicamente predominam os espermatozóides; esgotado: a gônada mostra-se flácida, coloração róseo-intensa; microscopicamente observa-se desorganização da estrutura do órgão, os septos são bastante espessos, grande quantidade de espermatogônias na periferia e no lúmen são vistos ainda espermatozóides residuais. Para fêmeas, em repouso: os ovários são achatados, coloração róseo alaranjada, vascularização delicada; microscopicamente predominam os ovocitos II; maturação: neste estádio já se observam ovócitos a olho desarmado, coloração laranja-acinzentada, ao microscópio óptico predominam ovocitos III; maduro: a gônada ocupa quase toda a cavidade abdominal, coloração cinza-esverdeada; histologicamente predominam os ovocitos IV; esgotado: órgão flácido, coloração róseo avermelhada; microscopicamente predominam folículos atrésicos e vazios.
Life history observations on a few interstitial Opisthobranch gastropods from the Gulf of Marseilles, Bouches du Rhône, France
Authors: Poizat Claude 
Published: March 2017

Foi estudada a vida reprodutiva das 5 espécies dominantes de opistobrânquios mediterrâneos intersticiais do Golfo de Marselha, Bouches-du-Rhône, França. Duas espécies hermafroditas Philine catena e Embletonia pulchra, provaram ser anuais, sendo a duração de vida da última ligeiramente maior que um ano no aquário. Essas duas espécies mostram, em biótopos de alta e média exposições, um único período de recrutamento no verão ou/e no outono, implicando em acasalmento no outono precedente, ovipostura no outono-inverno, eclosão das larvas e estabelecimento dos estádios meiobênticos jovens na areia, durante a estação quente, na primavera-verão. 0 Acochlidacea hermafrodito, Hedylopsis spiculifera, o qual pode sobreviver mais de um ano no aquário, é provavelmente também uma espécie anual, que passa por uma geração por ano. Contudo, uma fase flutuante de 4/5 meses, é registrada entre populações de biótopos de alta e média exposições: nos de média exposição há um recrutamento discreto na primavera enquanto que nos de alta exposição há um recrutamento mais importante no outono. Em biótopos de exposição intermediária há um prolongado período de recrutamento, do fim da primavera ao fim do outono e adultos podem ser observados no inverno e no verão. Os dois Acochlidiacea de sexos separados, Pontohedyle milaschewitschii e Unela glandulifera, mostraram ser espécies sub-anuais, cuja duração de vida é suposta ser não maior do que 6 a 7 meses; de fato, sua manutenção no aquário não ultrapassou algumas semanas. Essas duas espécies podem passar por 2 gerações por ano, desde que elas estejam no seu ambiente ótimo e se 2 estações de aquecimento (ou uma prolongada) forem registradas durante um ano, geralmente primavera e outono no Mediterrâneo. Uma primeira estação de ovipostura é presumida no inverno, eclosão e estabelecimento dos estádios jovens na areia, durante a primavera; esses jovens correspondem, onde e quando sobrevivem, à primeira geração descendente dos estádios adultos, alguns com espermatóforos, do outono precedente, morrendo no inverno após a ovipostura. Uma segunda estação de ovipostura, no verão ou/e outono, eclosão e estabelecimento no outono, corresponde à segunda geração; a última, bem sucedida na maioria dos cascalhos e areias, descende dos estádios adultos da primavera precedente, mortos no outono após a ovipostura. Uma certa fase flutuante é registrada entre populações de biótopos de exposição alta e média e em exposição intermediária parece haver reprodução quase o ano todo, exceto no inverno ou primavera. Os espermatóforos observados em P. milaschewitschii (até 3 por indivíduo) e U. glandulifera (1 ou 2 por indivíduo) são relevantes nos períodos de acasalmento na primavera e no outono.
Pacing as a Treatment for Reflex-Mediated (Vasovagal, Situational, or Carotid Sinus Hypersensitivity) Syncope: A Systematic Review for the 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society
Authors: Varosy Paul D. , Chen Lin Y. , Miller Amy L. , Noseworthy Peter A. , Slotwiner David J. , Thiruganasambandamoorthy Venkatesh 
Published: March 2017

Objectives:
To determine, using systematic review of the biomedical literature, whether pacing reduces risk of recurrent syncope and relevant clinical outcomes among adult patients with reflex-mediated syncope.

Methods:
MEDLINE (through PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials (through October 7, 2015) were searched for randomized trials and observational studies examining pacing and syncope, and the bibliographies of known systematic reviews were also examined. Studies were rejected for poor-quality study methods and for the lack of the population, intervention, comparator, or outcome(s) of interest.

Results:
Of 3188 citations reviewed, 10 studies met the inclusion criteria for systematic review, including a total of 676 patients. These included 9 randomized trials and 1 observational study. Of the 10 studies, 4 addressed patients with carotid sinus hypersensitivity, and the remaining 6 addressed vasovagal syncope. Among the 6 open-label (unblinded) studies, we found that pacing was associated with a 70% reduction in recurrent syncope (relative risk [RR]: 0.30; 95% confidence interval [CI]: 0.15–0.60). When the 2 analyzable studies with double-blinded methodology were considered separately, there was no clear benefit (RR: 0.73; 95% CI: 0.25–2.1), but confidence intervals were wide. The strongest evidence was from the randomized, double-blinded ISSUE-3 (Third International Study on Syncope of Uncertain Etiology) trial, which demonstrated a benefit of pacing among patients with recurrent syncope and asystole documented by implantable loop recorder.

Conclusions:
There are limited data with substantive evidence of outcome ascertainment bias, and only 2 studies with a double-blinded study design have been conducted. The evidence does not support the use of pacing for reflex-mediated syncope beyond patients with recurrent vasovagal syncope and asystole documented by implantable loop recorder.
Precipitation Budget of the Madden–Julian Oscillation
Authors: Adames Ángel F. 
Published: March 2017

Abstract
Column moisture and moist static energy (MSE) budgets have become common tools in the study of the processes responsible for the maintenance and evolution of the MJO. While many studies have shown that precipitation is spatially correlated with column moisture, these budgets do not directly describe the MJO-related precipitation anomalies. Other spatially varying fields may also play a role in determining the horizontal distribution of anomalous precipitation. In this study, an empirical precipitation anomaly field is derived that depends on three variables in addition to column moisture. These are the low-frequency distribution of precipitation, the low-frequency column saturation water vapor, and the sensitivity of precipitation to changes in column relative humidity. The addition of these fields improves upon moisture/MSE budgets by confining these anomalies to the climatologically rainy areas of the tropics, where MJO activity is strongest. The derived field adequately describes the MJO-related precipitation anomalies, comparing favorably with TRMM precipitation data.
Furthermore, a “precipitation budget” is presented that emphasizes moist processes over the regions where precipitation is most sensitive to free-tropospheric moisture. It is found that moistening from vertical moisture advection in association with regions of shallow ascent plays a central role in the propagation of the MJO. The overall contribution from this process is comparable to the contribution from horizontal moisture advection to propagation. Consistent with previous studies, it is found that vertical advection arising from longwave radiative heating maintains the intraseasonal precipitation anomalies against drying by horizontal moisture advection.
Feasibility testing of the Occupational Adaptation Practice Guide
Authors: Boone Anna E , George-Paschal Lorrie A 
Published: March 2017

Introduction The theory of occupational adaptation was articulated with an emphasis on client-centered and occupation-based practice. The Occupational Adaptation Practice Guide is an instrument designed to facilitate therapists’ application of this theory in evaluation and treatment planning to influence clients’ internal occupational adaptation and participation in daily life. Method The purpose of this study was to trial the instrument and to assess percentage of agreement and perceived feasibility of the Occupational Adaptation Practice Guide in an inpatient rehabilitation setting. Eight therapists completed the Occupational Adaptation Practice Guide according to a videoed case study for evaluation of percentage of agreement. Each therapist then administered the guide to separate clients and subsequently completed an open-ended questionnaire to assess acceptability and practicality feasibility. Results Percentage of agreement was 100% for motor control, perception and environmental ratings, with the cognition and psychosocial ratings each at 75%. Themes gathered from qualitative data revealed perceptions of the instrument as comprehensive and efficient. Conclusion The instrument was reported to be an efficient, thorough tool that facilitated the use of the theory of occupational adaptation.
Evidence-based interventions involving occupational therapists are needed in re-ablement for older community-living people: A systematic review
Authors: Pettersson Cecilia , Iwarsson Susanne 
Published: March 2017

Introduction Re-ablement services are in a period of strong development, but the terms and definitions used remain unclear, and the scientific evidence is still weak. The aim of this systematic review was to obtain an overview of the scientific literature in this evolving research area, and investigate whether there is scientific evidence for positive effects of re-ablement services for older community-living people. Method The systematic literature search was conducted in the databases CINAHL, PubMed and Svemed+(Swemed) and covered the years 2000–2014. Owing to the heterogeneity in the included studies, a narrative synthesis was performed. Results Eight original publications were found eligible and included in the systematic review. When addressed, terms and definitions varied among the papers. Effects such as less use of home care, higher likelihood to live at home, improved activities of daily living (ADL) skills, quality of life and physical health, increased physical activity and lower costs compared to conventional home care were reported. Conclusion More high-quality research is needed to strengthen the evidence-base regarding re-ablement services. The specific roles of various professional and staff groups are often insufficiently described, as are the interventions as such, and there is a lack of attention to person-centered aspects such as the meaningfulness of the specific activities.
Jacques Le Goff's Presence in India: A Very Personal Tribute
Authors: Mukhia Harbans 
Published: March 2017

AbstractThis paper pays a scholarly and personal tribute to Jacques Le Goff from the perspective of Indian historians. The introduction of the “New History” into India is traced back to its origins, showing the importance it had for the evolution of India's scholarship in history and the personal bonds that were created in course of time between Indian and French historians, with a special focus on Jacques Le Goff.
CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis
Authors: Bogie Jeroen FJ , Boelen Ellen , Louagie Els , Delputte Peter , Elewaut Dirk , van Horssen Jack , Hendriks Jerome JA , Hellings Niels 
Published: March 2017

Background: Phagocytes, such as macrophages and microglia, are key effector cells in the pathophysiology of multiple sclerosis (MS). It is widely accepted that they instigate and promote neuroinflammatory and neurodegenerative events in MS. An increasing amount of studies indicate that Siglec-1, also known CD169, is a marker for activated phagocytes in inflammatory disorders. Objective: In this study, we set out to define how CD169+ phagocytes contribute to neuroinflammation in MS. Methods: CD169-diphtheria toxin receptor (DTR) mice, which express human DTR under control of the CD169 promoter, were used to define the impact of CD169+ cells on neuroinflammation. Flow cytometry and immunohistochemistry were utilized to determine the expression and distribution of CD169. Results: We show that CD169 is highly expressed by lesional and circulating phagocytes in MS and experimental autoimmune encephalomyelitis (EAE). Our data further indicate that CD169 represents a selective marker for early activated microglia in MS and EAE lesions. Depletion of CD169+ cells markedly reduced neuroinflammation and ameliorated disease symptoms in EAE-affected mice. Conclusion: Our findings indicate that CD169+ cells promote neuroinflammation. Furthermore, they suggest that CD169+ phagocytes play a key role in the pathophysiology of MS. Hence, targeting CD169+ phagocytes may hold therapeutic value for MS.
Fighting Social Exclusion under EU Horizon 2020. Enhancing the Legal Enforceability of the Social Inclusion Recommendations?
Authors: Schoukens Paul , Smets Joris Beke 
Published: March 2017

In this article, we take a closer look at EU policy to promote social inclusion in the framework of the Europe 2020 strategy. Concretely the legal consequences of the incorporation of social inclusion in the employment guidelines will be addressed. Since the employment guidelines are now connected in a structural way to the economic guidelines, we take a closer look at the monitoring procedures that accompany the implementation of these economic guidelines. Furthermore we test the potential legal consequences of the integrated approach by unravelling (the formulation of) the social inclusion-related Country Specific Recommendations. A first legal consequence relates to the question of the extent to which the harder sanctioning tools, which have been developed for controlling the EU's economic recommendations, can be similarly applied to the guidelines relating to social inclusion (such as the application of EU fines in cases when recommendations are not followed up by states). In our opinion there is a spill-over effect only in relation to social inclusion recommendations that have sufficient economic or budgetary relevance (‘social inclusion recommendations of the negative kind’, supporting economic or budgetary goals). In other words, social inclusion recommendations that support only social objectives do not enjoy the stronger legal effects of the integrated monitoring approach. From analysis of the concrete Country Specific Recommendations we demonstrate that the incorporation of social inclusion into the employment guidelines has two additional consequences. On the one hand, social inclusion recommendations are nowadays formulated mainly in terms of employment objectives. On the other hand, the link with social inclusion also has implications for recommendations in the field of employment and economy that should not be to the detriment of social inclusion. In this way the horizontal clause of art. 9 TFEU seems to extend to non-legislative measures, such as the guidelines developed in socio-economic monitoring processes.