bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential clearance rate of proteins encoded on a self-amplifying mRNA vaccine in muscle and lymph nodes
Authors: Kanechi Reo , Shishido Tatsuya , Tachikawa Mana , Nishimura Tomohiro , Sawada Akihito , Okade Hayato , Ishikawa Daisuke , Yamaguchi Hitoshi , Araki Marito 
Published: October 2024

AbstractARCT-154, a recently approved self-amplifying mRNA (saRNA) vaccine, has been shown in clinical trials to induce higher levels of neutralizing antibodies and sustain them for a longer time than the conventional mRNA vaccine BNT162b2. However, the scientific evidence explaining this superiority remain elusive. Hence, we explored the temporal changes in spike protein and replicase components following a single dose of ARCT-154 vaccination in mice. The encoded spike protein reached its highest level approximately 3 days after vaccination and quickly disappeared from the rectus femoris muscle, the injection site. Although the spike protein levels also peaked at an early time point in the lymph nodes, it remained detectable 28 days after the vaccination and then disappeared by 44 days after the vaccination. Expression of nsP1, nsP2 and nsP4 was observed in the injected muscle and/or the lymph nodes for up to 15 days post-vaccination. These data suggest that prolonged expression of spike proteins in lymph nodes may, if not entirely, be responsible for the induction of higher and prolonged levels of neutralizing antibodies by the saRNA vaccine.
Cigarette smoke impairs the endocytotic process inSaccharomyces cerevisiae
Authors: Shukla Aditya , Sarkar Srimonti , Sil Alok Kumar 
Published: October 2024

AbstractThe accumulation of misfolded proteins inside the cells has been considered to be an important contributor to the development of cigarette smoke-mediated diseases. Since endocytosis plays a crucial role in protein trafficking and clearance, impaired endocytosis may contribute to cigarette smoke-mediated protein accumulation. Therefore, the current study investigated the effects of cigarette smoke extract (CSE) on the endocytosis process in yeastSaccharomyces cerevisiae. The current study showed that treatment of cells with CSE caused reduced uptake of FM4-64 stain, indicating impaired endocytosis. Further analysis revealed that CSE treatment resulted in a defect in the recruitment of proteins involved in endocytosis. Also, aberrant actin morphology was found upon CSE treatment, which might interfere with vesicle budding from the membrane. Moreover, the current study showed that the PI4,5P2 level in the plasma membrane in CSE treated cells is reduced due to the failed translocation of MSS4 kinase to the membrane. This reduced PI4,5P2 results in aberrant actin morphology. Thus, the current study demonstrates that CSE treatment causes endocytosis defects and provides insight into this defective endocytosis.
Diversity and characteristics of the oral microbiome influenced by race and ethnicity
Authors: Wang Qingguo , Wang Bing-Yan , Williams She’Neka , Xie Hua 
Published: October 2024

AbstractPeriodontitis disproportionately affects racial/ethnic populations. Besides social determinants contributing to disparities in periodontal health, variations of oral microbial communities may also be a key factor influencing oral immune responses. To characterize the oral microbiome from different racial/ethnic populations, we collected 161 dental plaque samples from African Americans (AAs), Caucasian Americans (CAs), and Hispanic Americans (HAs) with clinical gingival health or biofilm-induced gingivitis on an intact periodontium. Using metagenomic sequencing, we found significant difference in diversity and abundance of microbial taxa in the dental plaque samples from AA, CA, and HA groups and unique microbial species that can only be detected in a particular racial/ethnic group. Moreover, we revealed racial/ethnic associated variations in functional potential of the oral microbiome, showing that diversity and abundance of antibiotic resistant genes were greater in the oral microbiome of the AAs than those in CAs or HAs, and that the AAs exhibited higher levels of genes involving in modification of glycoconjugates, oligo- and polysaccharides. These findings indicate more complex and higher virulence potential oral microbiome in AA and HA populations, which likely contributes to higher prevalence of periodontitis in AAs and HAs.ImportanceRecognizing the variations in the oral microbiome among racial/ethnic populations offers insight into the microbial determinants contributing to oral health disparities. In the study presented here, we found a higher level of bleeding on probing (BOP), an indicator of tissue inflammatory response, in the AA group, which is correspondence with a more complex oral microbiome detected in this group. Our observations suggest that the variations of the oral microbiome associated with racial/ethnic backgrounds may directly relate to their virulence potential including their abilities to induce host immune responses and to resist antibiotic treatment. Therefore, these finding can be a stepping stone for developing precision medicine and personalized periodontal prevention/treatment and for reducing oral health disparities.
Capabilities to create new value for business sustainability: a retailer case study from Malaysia
Authors: Chan Cassandra Yi Rong , Zailani Suhaiza 
Published: October 2024

PurposeThe lack of a direct link between business value and sustainability is a critical roadblock to truly embedding sustainability in business strategies. Before launching the sustainability journey, every organisation should answer the question: “What value would this strategy offer our organisation?” Conversely, when organisations are opportunistic toward quick profits, the negative consequences of one domain spill over to another. The desire to produce more may result in overproduction, overconsumption or environmental pollution.Design/methodology/approachTo give a complete analysis of sustainable capabilities, this study combines current theoretical understanding from past literature, followed by exploratory interviews and a thorough case study. The case study ventured into uncharted territories, unveiling an exciting new sphere of value catalysed by the mechanisms of sustainable co-creation. Additionally, it exposed thought-provoking motives driving supply chain actors’ unwavering commitment to ethical decision-making, even amidst towering challenges.FindingsOur empirical lens reveals the hidden mechanics of resource sharing and the genesis of newfound value, illuminating previously obscure corners of the sustainability field. Moreover, it sheds light on retailers striving to cultivate green retail supply chains. It delivers an actionable framework that bolsters business sustainability and fuels competitive edge, which is vital in the rapidly evolving landscapes of emerging economies.Originality/valueThis study offers insights into the sustainable value-creation mechanism in ALPHA, a Malaysian retailer, uncovering how supply chain actors’ business activities generate economic, social and environmental performance.
Intelligent identification of risks in construction contract clauses based on semantic reasoning
Authors: Zhou Hong , Zhou Li , Gao Binwei , Huang Wen , Huang Wenlu , Zuo Jian , Zhao Xianbo 
Published: October 2024

Purpose The number of construction dispute cases has surged in recent years. The effective exploration and management of risks associated with construction contracts helps to directly enhance the overall project performance. The existing approaches to identify the risks associated with construction project contracts have a heavy reliance on manual review techniques, which are inefficient and highly restricted by personnel experience. The existing intelligent approaches only work for the contract query and storage. Hence, it is necessary to improve the intelligence level for contract risk management. This study aims to propose a novel method for the intelligent identification of risks in construction contract clauses based on natural language processing.Design/methodology/approach This proposed method can formalize the linguistic logic and semantic information of contract clauses into multiple triples and transform the structural processing results of general clauses in a construction contract into rights and interests rules for risk review. In addition, the core semantic information of special clauses in a construction contract, rights and interests rules are used for semantic conflict detection. Finally, this study achieves the intelligent risk identification of construction contract clauses.Findings The method is verified by selecting several construction contracts that had been applied in engineering contracting as a corpus. The results showed a high level of accuracy and applicability of the proposed method.Originality/value This novel method can identify the risks in contract clauses with complex syntactic structures and realize rule extension according to the semantic relation network of the ontology. It can support efficient contract review and assist the decision-making process in contract risk management.
Navigating complex riskscapes: the Koudiet Eddraouch GIS substation project in Sub-Saharan Africa
Authors: Kumar Sunil , Shrivastava Ravindra 
Published: October 2024

Learning outcomes
Risk identification and qualitative assessment are the learning outcomes.

Case overview/synopsis
The Bharat Bijlee Construction Limited (BBCL) was one of the largest construction companies operating in the power sector in India. After successfully completing a few projects in the Middle East, BBCL decided to expand its presence into African region. The BBCL was awarded a $85m contract for three sub-station projects to modernise Algeria’s power grid system by the “Shariket Karhaba Koudiet Eddraouch Spa”, a state-owned company in charge of power generation, transmission and distribution in Algeria.
The project, which is the first of BBCL in Saharan region in Algeria’s, presents many unique situations that company had never encountered before, including sand dunes, severe weather, remote locations, supply chain & logistics, strict contractual deadlines and a high level of construction risk. The project manager for BBCL was sceptic about how well his company would perform under the present project circumstances. How could he better align himself with the client, the various on-site local contractors and the numerous suppliers spread around the world?
The case emphasises the identification of various project risks that the project manager might encounter in the project. What do the PESTLE and ASCE frameworks for risk identification each represent, and how are they helpful for the project team in understanding various risks? How should the project’s qualitative risk assessment be conducted? And how can a heat map be a better tool for comprehending the criticality of each risk in the project?

Complexity academic level
Undergraduate and post graduate courses in project management, civil engineering and architecture domain.

Supplementary material
Teaching notes are available for educators only.

Subject code
CSS 2: Built Environment.
Monetary discounts, metaphoric communication and mass prestige based branding: a comprehensive assessment
Authors: Das Manish , Jebarajakirthy Charles , M.S. Balaji , Saha Victor , Paul Mrinal Kanti , Sivapalan Achchuthan 
Published: October 2024

Purpose
This study aims to examine the role of price discounts and how to communite such discounts for masstige brands. While a price discount might encourage potential (first time) customers seeking higher status to buy a masstige brand, it might deter existing (repeat) customers from purchasing the brand due to a decline in perceived status. Such paradoxical effect of price discounts on masstige brand’s purchase requires a detail investigation into whether masstige brands should offer price discounts and if so, how to communicate such discounts. Current research investigates this phenomenon.

Design/methodology/approach
Four experimental studies were executed. Study 1 investigated the impact of monetary discount (absent vs. present) on the purchase intention of masstige brands for different customer types (potential vs. existing). Study 2 investigated the mediating role of perceived status. Study 3 examined the effectiveness of metaphoric communication of monetary discounts (absent vs present) on masstige brand’s purchase. Study 4 tested the moderating effect of customers’ need for cognition.

Findings
Overall, monetary discounts positively affect purchase intention of masstige brand; however, the effect is negative for existing customers and positive for potential customers owing to differences in perceived status these customer groups experience (positive for potential and negative for existing customers). Metaphoric communications of monetary discounts restrict the declining purchase intention and status perception of existing customers besides keeping the potential customers’ purchase intention intact.

Research limitations/implications
This research is confined to a particular country limiting the gneralisability of the study’s findings. Furthermore, this research is cross-sectional in nature.

Practical implications
The findings of this research provide valuable insights and actionable recommendations for masstige brands to effectively leverage price discounts, especially in the emerging markets.

Originality/value
To date, a question of whether or not masstige brands should offer price discounts and if so, how to communicate such discounts remain opaque. This is the pioneering study exploring this phenomenon.
Age-inclusive hospitality and tourism: navigating the metaverse travel with avatar
Authors: Hao Fei , Back Ki-Joon , Chon Kaye Kye Sung Kye-Sung 
Published: October 2024

Purpose
This study aims to investigate the impact of virtual tours on the engagement and travel intentions of older adults, emphasizing the role of emotional and informative content. It aims to enhance travel confidence and reduce stress among older travelers, fostering inclusive tourism through advanced avatar technology.

Design/methodology/approach
Using two between-subjects experiments, this research compares the effects of emotion-driven and knowledge-centric virtual tours on older adults. It explores the mediating role of travel confidence and stress reduction, along with the moderating influence of positive psychological cues on engagement and travel intentions.

Findings
The results highlight the potential of technology in promoting inclusive tourism. Emotionally engaging virtual tours significantly increase travel intentions among older adults by boosting confidence and alleviating stress, with positive psychological cues enhancing these effects.

Practical implications
This study offers valuable insights for tourism industry stakeholders by suggesting the development of avatar-based virtual tours tailored to the emotional and cognitive needs of older travelers. This approach could create more accessible and satisfying tourism experiences for older travelers.

Originality/value
This study extends the socioemotional selectivity theory to the realm of metaverse travel, providing a novel perspective on the emotional and cognitive engagement of older adults in the metaverse. This underscores the importance of inclusive technology in addressing the needs of older travelers.
Succession planning practices and succession success in family-owned businesses: the role of leadership style as internal branding mechanism
Authors: Coffie Isaac Sewornu , Müller Re-an , Marfo Mensah , Ocloo Elikem Chosniel , de Klerk Natasha 
Published: October 2024

PurposeAlthough leadership style plays a critical role in succession planning practices and succession success, empirical examination of its influence on the relationship between succession planning and success of succession in family-owned SMEs has received little attention in the literature. This study examines the interactive effect of the various types of leadership styles as internal branding mechanisms on the success of succession in family-owned SMEs.Design/methodology/approachWe analyzed the data from 124 managers/CEOs of family-owned SMEs that have at least transitioned beyond one incumbent leader using SPSS Version 29.FindingsThe result shows that succession planning practices are positively associated with succession success. It further shows that leaders who brand themselves as transformational and participatory leaders have a positive, significant interactive effect on the relationship between succession planning activities and succession success. The positive relationship between succession planning activities and succession success is dampened when managers rely too heavily on a transactional leadership style. Both autocratic and laissez-faire types of leadership have no significant interactive effect on the relationship.Originality/valueThe study is distinct from past studies. Until now, knowledge about the interactive effect of the various leadership styles as internal branding mechanisms on the relationship between succession planning practices like coaching, mentoring, job rotation and training and succession success in family-owned businesses remains limited. Theoretically, the study is pioneering in the sense that it is among the first studies that extends internal branding to succession planning in family-owned businesses. The study enlightened our understanding of how the various leadership styles and internal branding mechanism influence succession success in family-owned SMEs.
AI empowered academia: a fuzzy prioritization framework for academic challenges
Authors: Gupta Sanjay , Kaur Supreet , Gupta Meenu , Singh Tejinderpal 
Published: October 2024

Purpose
The rapid expansion of artificial intelligence (AI) is progressively reshaping the dynamics of human interaction, communication, lifestyle, education and professional endeavors. The purpose of the study is to comprehend and address the barriers which are impeding the implementation of Generative AI Technologies, such as ChatGPT in the educational landscape.

Design/methodology/approach
The study used the Fuzzy analytic hierarchy process (AHP) model to analyze the responses gathered from 149 academicians belonging to the northern states of India.

Findings
The study established that the three most important criteria that influence the adoption of generative AI in the education sector are Risk of Academic Integrity, Risk of biased outcomes and Erosion of Critical Thinking.

Research limitations/implications
The present study was confined to Fuzzy AHP to extract the critical criteria influencing the decision-making. Various other techniques such as PF-Delphi and PF-CoCoSo can be used further. The results provide significant inputs for future research to understand the effect of adoption of Generative AI in different contexts including both opportunities and the challenges faced by them.

Practical implications
The study will be beneficial to various stakeholders including students, educators, society and policymakers as the study will highlight the importance of AI tools, introduce the various challenges associated with and explain the use of these tools as productivity-enhancing tools.

Originality/value
To the best of the author’s knowledge, the present study is a novice as the use of AI in Academia is unexplored and the major criteria influencing the choices have yet been undiscovered.
When knowledge workers meet AI? The double-edged sword effects of AI adoption on innovative work behavior
Authors: Dong Xueyan , Tian Yuxin , He Mingming , Wang Tienan 
Published: October 2024

Purpose
The purpose of this study was to investigate the impact of artificial intelligence (AI) adoption on knowledge workers' innovative work behaviors (IWB), as well as the mediating role of stress appraisal and the moderating role of individual learning abilities.

Design/methodology/approach
This study analyzed the questionnaire results of 313 knowledge workers, and data analysis was conducted by using SPSS 25.0, SPSS 25.0 macro-PROCESS and AMOS 28.0.

Findings
This study found that AI adoption has a double-edged sword effect on knowledge workers' IWB. Specifically, AI adoption can promote IWB by enhancing knowledge workers' challenging stress appraisal, while inhibiting IWB by fostering their hindering stress appraisal. Moreover, individual learning ability significantly moderated the relationship between AI adoption and stress appraisal, which further influenced IWB.

Originality/value
This study integrates the conflicting findings of previous studies and proposes a comprehensive theoretical model based on the theory of cognitive appraisal of stress. This study enriches the research on AI in the field of knowledge management, especially extending the understanding of the relationship between AI adoption and knowledge workers’ IWB by unraveling the psychological mechanisms and behavior outcomes of users' technology usage. Additionally, we provide new insights and suggestions for organizations to seek the cooperation and support of employees in introducing new technologies or driving intelligent transformation.
For the sake of my job security: examining the effect of age-based stereotype threat on older workers’ knowledge hiding
Authors: Duan Yongjia , Liu Huihua , Wang Zhenyuan , Tse Herman H.M. 
Published: October 2024

Purpose
Organizations can greatly benefit from the transfer of knowledge from older employees to younger generations. However, older workers often hesitate to share their expertise with their younger colleagues. Grounded in conservation of resources theory and the stereotype threat framework, this study aims at examining the negative impact of age-based stereotype threat on organizational knowledge management.

Design/methodology/approach
The authors developed a moderated mediation model and collected data from 219 older workers with a time-lagged design to explore the effect of age-based stereotype threat on older workers’ knowledge hiding.

Findings
The results showed that age-based stereotype threat could lead to knowledge hiding behaviors among older workers due to increased job insecurity, and leader-member exchange can potentially mitigate these effects.

Originality/value
The findings underscore the detrimental effect of age-based stereotype threat on organizational knowledge management and suggest that organizations should foster an age-inclusive environment to facilitate effective intergenerational knowledge transfer.
Antecedents the adoption of tour itineraries from smart travel apps: an integration of experiential consumption theory and innovation resistance theory
Authors: Khan Salman , Mehmood Shafaqat 
Published: October 2024

Purpose
The purpose of this study investigate the antecedents the adoption of tour itineraries from smart travel apps. Travelers are progressively expanding their smart travel planning applications to organize their trip-related activities. With the help of these apps, users achieve their favorite tour itineraries and choose their preferred destinations.

Design/methodology/approach
This study aimed to examine the results of smart tour itineraries on travelers and elucidate the motivations for their continual use and why travel experts are increasingly using smart tour itineraries. Innovation resistance and experiential consumption theories were used in this study. SmartPLS 3.2.8 was used to consider 682 valid samples using structural equation modeling (SEM).

Findings
This analysis identified the following crucial factors: usage, value, risk and traditional barriers. Moreover, utilitarian and hedonic values significantly affected barriers. Finally, theoretical and practical suggestions are presented along with future research directions.

Originality/value
This study encompasses the tender of innovation resistance theory to travel itineraries by integrating experiential consumption theory in the context of smart tourism apps.