bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-reports of sexual attraction change in a sample of male psychotherapy consumers in a private practice setting
Authors: Phelan James Edward 
Published: March 2017

The purpose of this study was to see if clients in a private practice therapy setting reported any changes in how they rated their sexual attraction, their stated goal. The therapy was conducted weekly, lasting at least one year. The sample was comprised of 30 men whose desired goal was toward a shift from same-sex attraction to opposite-sex attraction. A convenience sample from the author’s private practice, over a 5-year span, was used. Clients were invited to complete surveys at intake, between 12-18 months into therapy, and one year afterwards. Following the format of the Klein Sexual Orientation Grid, clients were asked about sexual attraction on a measurable continuum. A repeated-measures analysis of variance (ANOVA) was used to test the differences between the pre, mid, and post responses. In this sample, at 1 year post-discharge, 10% reported their sexual attraction as “for the other sex somewhat” vs. 0 % at baseline; 17% reported their sexual attraction as “for the other sex mostly” vs. 0 % at baseline; and 23% reported their sexual attraction was “for the other sex only” vs. 0 % at baseline. These outcomes proved statistically significant changes from baseline compared to follow up. Despite the study’s limitations, significant sexual attraction shifts from same-sex to opposite-sex were self-reported in a highly motivated clinical sample of men.
Rate and Temporal Coding Convey Multisensory Information in Primary Sensory Cortices
Authors: Bieler Malte , Sieben Kay , Cichon Nicole , Schildt Sandra , Röder Brigitte , Hanganu-Opatz Ileana L. 
Published: March 2017

AbstractOptimal behavior and survival result from integration of information across sensory systems. Modulation of network activity at the level of primary sensory cortices has been identified as a mechanism of cross-modal integration, yet its cellular substrate is still poorly understood. Here, we uncover the mechanisms by which individual neurons in primary somatosensory (S1) and visual (V1) cortices encode visual-tactile stimuli. For this, simultaneous extracellular recordings were performed from all layers of the S1 barrel field and V1 in Brown Norway ratsin vivoand units were clustered and assigned to pyramidal neurons (PYRs) and interneurons (INs). We show that visual-tactile stimulation modulates the firing rate of a relatively low fraction of neurons throughout all cortical layers. Generally, it augments the firing of INs and decreases the activity of PYRs. Moreover, bimodal stimulation shapes the timing of neuronal firing by strengthening the phase-coupling between neuronal discharge and theta–beta band network oscillations as well as by modulating spiking onset. Sparse direct axonal projections between neurons in S1 and V1 seem to time the spike trains between the two cortical areas and, thus, may act as a substrate of cross-modal modulation. These results indicate that few cortical neurons mediate multisensory effects in primary sensory areas by directly encoding cross-modal information by their rate and timing of firing.
A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors
Authors: Shiwarski Daniel J. , Tipton Alycia , Giraldo Melissa D. , Schmidt Brigitte F. , Gold Michael S. , Pradhan Amynah A. , Puthenveedu Manojkumar A. 
Published: March 2017

The δ opioid receptor (δR) is a promising alternate target for pain management because δR agonists show decreased abuse potential compared with current opioid analgesics that target the μ opioid receptor. A critical limitation in developing δR as an analgesic target, however, is that δR agonists show relatively low efficacyin vivo, requiring the use of high doses that often cause adverse effects, such as convulsions. Here we tested whether intracellular retention of δR in sensory neurons contributes to this low δR agonist efficacyin vivoby limiting surface δR expression. Using direct visualization of δR trafficking and localization, we define a phosphatase and tensin homolog (PTEN)-regulated checkpoint that retains δR in the Golgi and decreases surface delivery in rat and mice sensory neurons. PTEN inhibition releases δR from this checkpoint and stimulates delivery of exogenous and endogenous δR to the neuronal surface bothin vitroandin vivo. PTEN inhibitionin vivoincreases the percentage of TG neurons expressing δR on the surface and allows efficient δR-mediated antihyperalgesia in mice. Together, we define a critical role for PTEN in regulating the surface delivery and bioavailability of the δR, explain the low efficacy of δR agonistsin vivo, and provide evidence that active δR relocation is a viable strategy to increase δR antinociception.SIGNIFICANCE STATEMENTOpioid analgesics, such as morphine, which target the μ opioid receptor (μR), have been the mainstay of pain management, but their use is highly limited by adverse effects and their variable efficacy in chronic pain. Identifying alternate analgesic targets is therefore of great significance. Although the δ opioid receptor (δR) is an attractive option, a critical limiting factor in developing δR as a target has been the low efficacy of δR agonists. Why δR agonists show low efficacy is still under debate. This study provides mechanistic and functional data that intracellular localization of δR in neurons is a key factor that contributes to low agonist efficacy, and presents a proof of mechanism that relocating δR improves efficacy.
Metabolic constraints on the evolution of antibiotic resistance
Authors: Zampieri Mattia , Enke Tim , Chubukov Victor , Ricci Vito , Piddock Laura , Sauer Uwe 
Published: March 2017

AbstractDespite our continuous improvement in understanding antibiotic resistance, the interplay between natural selection of resistance mutations and the environment remains unclear. To investigate the role of bacterial metabolism in constraining the evolution of antibiotic resistance, we evolved Escherichia coli growing on glycolytic or gluconeogenic carbon sources to the selective pressure of three different antibiotics. Profiling more than 500 intracellular and extracellular putative metabolites in 190 evolved populations revealed that carbon and energy metabolism strongly constrained the evolutionary trajectories, both in terms of speed and mode of resistance acquisition. To interpret and explore the space of metabolome changes, we developed a novel constraint‐based modeling approach using the concept of shadow prices. This analysis, together with genome resequencing of resistant populations, identified condition‐dependent compensatory mechanisms of antibiotic resistance, such as the shift from respiratory to fermentative metabolism of glucose upon overexpression of efflux pumps. Moreover, metabolome‐based predictions revealed emerging weaknesses in resistant strains, such as the hypersensitivity to fosfomycin of ampicillin‐resistant strains. Overall, resolving metabolic adaptation throughout antibiotic‐driven evolutionary trajectories opens new perspectives in the fight against emerging antibiotic resistance.
Motives for online gaming questionnaire: Its psychometric properties and correlation with Internet gaming disorder symptoms among Chinese people
Authors: Wu Anise M. S. , Lai Mark H. C. , Yu Shu , Lau Joseph T. F. , Lei Man-wai 
Published: March 2017

Background and aims
Internet gaming disorder (IGD) imposes a potential public health threat worldwide. Gaming motives are potentially salient factors of IGD, but research on Chinese gaming motives is scarce. This study empirically evaluated the psychometric properties of the Chinese version of the Motives for Online Gaming Questionnaire (C-MOGQ), the first inventory that measures seven different gaming motives applicable to all type of online games. We also investigated the associations between various gaming motives and IGD symptoms among Chinese gamers.

Methods
Three hundred and eighty-three Chinese adult online gamers (Mean age = 23.7 years) voluntarily completed our online, anonymous survey in December 2015.

Results
The confirmatory factor analysis results supported a bi-factor model with a general factor subsuming all C-MOGQ items (General Motivation) and seven uncorrelated domain-specific factors (Escape, Coping, Fantasy, Skill Development, Recreation, Competition, and Social). High internal consistencies of the overall scale and subscales were observed. The criterion-related validity of this Chinese version was also supported by the positive correlations of C-MOGQ scale scores with psychological need satisfaction and time spent gaming. Furthermore, we found that high General Motivation (coupled with high Escape motive and low Skill Development motive) was associated with more IGD symptoms reported by our Chinese participants.

Discussion and conclusions
Our findings demonstrated the utility of C-MOGQ in measuring gaming motives of Chinese online gamers, and we recommend the consideration of both its total score and subscale scores in future studies.
Politeness in Using Banjarese and American English Personal Subject Pronouns by English Department Students of Lambung Mangkurat University
Authors: Arapah Elvina , Mu’in Fatchul 
Published: March 2017

This research is aimed at describing the use of personal pronouns of Banjarese and American English.The research uses the Convergent Parallel Design. Data are collected by using two kinds of questionnaires. The first is for 37 students belonging to Banjar Kuala Dialect (BKD), and the second is for 24 students belonging to Banjar Hulu Dialect (BHD). Research result shows that Banjarese and American English’ pronouns are based on singular and plural distinction although Banjarese does not have a gender distinction as in the American English. The personal pronouns are the first, second and third persons. English personal pronouns depend mostly on the grammatical role while Banjarese personal pronouns can indicate the social status or the relation of the speaker and other persons in the discourse. Personal pronouns can reveal the social status, and they can the politeness or impoliteness of the speakers.
ESTRATÉGIAS DE ENSINO E APRENDIZAGEM DE VOCABULÁRIO EM SEGUNDA LÍNGUA E O EMPREGO DAS EXPRESSÕES IDIOMÁTICAS
Authors: Hogetop Monica 
Published: March 2017

RESUMO De acordo com Nation (2011), Schmitt (2000) e Richards (1976), a maior parte da pesquisa existente sobre ensino do vocabulário até o momento tem tido como foco a compreensão e a produção escritas. O presente estudo justifica-se por somar-se a outros trabalhos que enfocam as expressões idiomáticas, no escopo do ensino e da aprendizagem de línguas estrangeiras. Diante da necessidade de contribuir para estudos nessa área, o objetivo deste artigo é analisar a relação existente entre as estratégias de ensino e de aprendizagem de vocabulário e o emprego de expressões idiomáticas. Além disso, pretende-se analisar como o vocabulário está sendo enfocado em sala de aula e o consequente emprego das expressões idiomáticas nos livros didáticos de língua estrangeira.
REDES EM CONTEXTOS DE APRENDIZAGEM: POSSIBILIDADE DE CONHECIMENTO-REGULAÇÃO E/OU EMANCIPAÇÃO
Authors: Linhares Maria Conceição da Silva 
Published: March 2017

Este artigo discute as redes como contextos de aprendizagem
que refletem na construção tanto do conhecimento-
regulação como do conhecimento-emancipação.
Dependendo da concepção, da recepção e da
utilização, tanto pode servir para subordinar o conhecimento
a uma perspectiva hegemônica, racionalista e
linear como pode valorizar a diversidade dos saberes
e linguagens em direção a solidariedade e a humanização.
A análise se pauta na metodologia de estudo
bibliográfico fundamentado em autores, como Adorno
(1995) para discutir a semiformação, Boaventura de
Sousa Santos (2000, 2004), conhecimento-regulação
e conhecimento-emancipação e Castells (2000, 2004,
2009), as redes como fluxo de comunicação, dentre
outros. Os resultados apontam que se os contextos de
aprendizagem com redes forem identificados e refletidos
contribuem para uma vivência significativa com
estas e com a informação por elas articulada, ao atribuir
sentido ao que se lê, quando se identifica o quê, o
como e o para quê da informação; funciona como guia
para elucidar o conhecimento-regulação e suscitar o
conhecimento-emancipação.
DISPOSITIVOS DIGITAIS E APRENDIZAGEM UBÍQUA: UM EXPERIMENTO COM A INVERSÃO DE SALA DE AULA
Authors: Oliveira Kaio Eduardo de Jesus , Alves André Luiz , Porto Cristiane de Magalhães 
Published: March 2017

Este trabalho tem como objetivo geral discutir a relação
entre tecnologias digitais, novas formas de ensinar
e aprender por meio da metodologia de sala de
aula invertida. Na elaboração deste texto, nos pautamos
em dois tipos de pesquisa distintos: a pesquisa
bibliográfica, para articular conceitos e ideias pertinentes
à temática, utilizando autores como Lucia Santaella
(2010, 2013); André Lemos (2007, 2009, 2013);
e a pesquisa etnográfica com o objetivo de analisar
por intermédio da observação participante a construção
do processo educativo mediado por tecnologias
digitais em uma turma da disciplina Produção Textual
II, do curso de Comunicação Social da Universidade
Tiradentes – UNIT, Sergipe. Por meio desta pesquisa
pode-se constatar que os dispositivos digitais articulados
a Internet possibilitam novas formas de ensinar
aprender e permitem a articulação de novas metodologias
de ensino. Além disso, transformam o processo
comunicacional e social dos indivíduos, possibilitando
também o acesso ilimitado à informação em qualquer
lugar e a qualquer hora, criando espaços e aprendizagens
ubíquas por processos híbridos.
Variabilidade temporal do volume e caracterização física e química dos sedimentos do açude São José III no Cariri Paraibano
Authors: Monteiro Danilo Rodrigues , Silva Tainara Tâmara Santiago , Farias Maria Sallydelândia Sobral , Oliveira Hallyson , Souza Felipe Guedes de 
Published: March 2017

Esse trabalho teve como objetivo analisar os características físico-químicas do sedimento do Açude de São José III, situado no município de São José dos Cordeiros no estado da Paraíba, bem como a pluviometria da região e o volume do manancial nos últimos 5 anos. Realizou-se a coleta do sedimento no Açude São José III, em três pontos distintos (A-Fundo do manancial; B-Margem do açude – depósito de resíduos; C-Margem do açude-área agricultável) a uma profundidade de 0-30 cm com auxílio de trado manual, pás plásticas e tubos de PVC (50 mm de diâmetro) e acondicionadas em sacos plásticos. Após a coleta, as amostras passaram por secagem ao ar, destorroadas e enviadas ao Laboratório de Irrigação e Salinidade (LIS-UFCG), para realização das análises física e químicas. Afirma-se com os dados pluviométricos o ano que apresentou a maior média foi o de 2009 (103,89 mm) e o de menor foi o de 2012 (16,59 mm). A análise granulométrica dos sedimentos revelou que o sedimento da amostra A (Fundo do Manancial) possui 50,06% de argila. As amostras de sedimento B (Margem do Manancial – Depósito de resíduos) e C (Margem do Manancial - Área agricultável) apresentaram uma fração de areia superior (B-80,74%; C-62,64%), na caracterização química percebeu-se que a razão C/N obtida nas amostras do açude São José III possuem origem de ambientes terrestres e aquáticos.Temporal variability of the volume and physical and chemical characterization of sediment weir São José III in Cariri ParaibanoAbstract: This study has how to objective to analyze the physical and chemical characteristics of the sediment of São José III, located in São José dos Cordeiros - PB, as well as the rainfall of the region and the volume of the weir the last 5 years. Held the collection of the sediment weir São José III, at three different points (A-Fund of the weir, B-border of the weir - waste disposal; C-Border of the weir - arable area) to a depth of 0-30 cm with the support of manual auger, plastic blades and PVC tubes (50 mm diameter) and packed in plastic bags. After collect, the samples passed air drying, broken into pieces and sent to the Laboratory of Irrigation and Salinity (LIS-UFCG), to peform the physical and chemical analyzes. Says with the rainfall data for the year with the highest average was 2009 (103.89 mm) and the lowest was observed in 2012 (16.59 mm). The particle size analysis of the sediment revealed that the sediment sample A (Fund of the weir) has 50.06% argil. Sediment samples B (Border of the weir – waste disposal) and C (Border of the weir - arable area) showed a higher sand fraction (B-80, 74%, C-62, 64%), realized that the chemical characterization to C/N ratio in the samples of the weir São José III have origin of terrestrial and aquatic environments.
ФУНКЦИОНОВАНЄ КОНСТРУКЦИЇ/ФОРМИ ВØ У ПРИПОВЕДКИ ДАВНИ ПАЙТАШКИ ГАВРИЇЛА КОСТЕЛЬНИКА
Authors: Фейса Михайло 
Published: March 2017

У роботи анализовани часово-видски одношеня у приповедки Давни аֲйֳ аֵ ки др Гавриїла Костельника, хторого ше трима за основопокладателя руского язика. Гоч увага автора фокусована на часове и видове функционованє конструкциї В-ø, автор, медзитим, увагу пошвецує и шицким дїєсловним формом у хторих дїєслова заступени з форму В-ø, т. є. и гевтим случайом кед форма и конструкция В-ø идентични и гевтим случайом кед форма В-ø лєм состойна часц других конструкцийох. На тот способ практично цала дїєсловна система руского язика спатрена прейґ найфреквентнєйшей и, функционално патраци, найрозконареншей форми у нєй. Першираз редефинована методолоґия до хторей ше пришло з контрастивну анализу применєна и на конкретни линґвистични материял руского язика. Обезпечени и статистични податки у вязи зоз фреквенцию атотивних (87,98 %) и тотивних дїєсловох (12,02 %).
Relação entre caso morfológico e caso abstrato na língua Ka'apor
Authors: Cabana Nasle Maria 
Published: March 2017

Neste artigo apresento uma análise sobre a relação entre atribuição do Caso abstrato e marcas morfológicas de caso na língua Ka’apor. Mostro que esta língua apresenta alternância na marcação do sujeito e do objeto, mas que são fenômenos resultados de processos diferentes. Em relação ao sujeito, assumo que esta língua apresenta atribuição diferente do Caso abstrato. Alguns sujeitos recebem o Caso resultado de relações estruturais e outros o Caso inerente tendo em vista que estão evolvidos determinados papéis temáticos. Já os objetos recebem uniformemente o Caso abstrato via relações estruturais, mas apresentam marcas morfológicas diferentes conforme sejam ou não altos considerando a escala de animacidade e de definitude.
Rethinking the Typical Line-Item DWOP Exercise: Does it Present a Complete Picture?
Authors: Nwokoma Precious , Knobben Xander 
Published: March 2017

Abstract
The Drill Well on Paper (DWOP) exercise is an accepted tool for use in planning an offshore well, and in post-drilling analysis to demonstrate real and potential efficiency gains when comparing latest generation drilling and floater designs. However, given accelerated advances in drilling systems and operational practices, does the DWOP methodology of strictly analyzing fixed line-item data adequately capture non-apparent flat time and enhance overall operational efficiencies?
This paper explores areas where the traditional DWOP may not clearly reflect the efficiencies and HSE gains intrinsic of the latest generation drilling environment, and makes the case for transforming to more of a project management-like approach. For instance, efficiencies demonstrating reduced well delivery days would logically translate into a corresponding reduction in injuries/man-hour, but results of that accepted metric are not recorded in a post-well DWOP. Additionally, despite simultaneous rig operations, often denoted as off-line activities, the typical DWOP only looks at one operation, or line item, at a time. Thus, any efficiencies or bottlenecks in these parallel operations are often neither identified nor recorded in the DWOP.
The authors will present direct comparisons to illustrate how a typical DWOP exercise may not capture and detail the consequential reductions in lost time incident rates (LTIR), flat times and invisible lost time (ILT) achievable with advanced rigs and drilling systems. Standardized robotic pipe manipulators, floaters with increased storage capacity for casing and other consumables that reduce supply vessel requirements, and new rig designs and/or moon pool dimensions that widen the operable window and reduce weather-related downtime, are among the efficiency drivers the authors suggest should be reflected in a DWOP analysis. Additionally, improved operational practices, like pre-installation of casing centralizers, and automated pipe tally and monitoring systems contribute to improved efficiencies and economics, which further justify modifications to the standard DWOP thought process.
This paper aims to broaden the readers our understanding of how deepwater rigs can be assessed with respect to efficiency and HSE gains; thereby, leading to a rethinking of the current methodology used in rig comparison DWOPs.
Kick Tolerance and Frictional Pressure Losses, Added Safety or Added Risk?
Authors: Mosti I. , Morrell D. , Anfinsen B. T. , Vielma W. E. , Nergaard K. 
Published: March 2017

Abstract
Annulus frictional pressure losses can be significant in certain application and should be considered in the planning phase to correctly calculate a meaningful safety margin for kick tolerance. Kick tolerance is an integral part of the well construction workflow. The formation, casing and well control equipment should withstand the pressure when shutting in and circulating a given kick volume to surface. At its simplest, the kick tolerance will be calculated based on the pressure in the well when the kick front is at the casing shoe, giving the highest pressure load at the shoe.
Safety margins are factored in by adding a given additional pressure as a safety factor in the calculations. This is often a pre-defined value in the technical requirements within the company. In deep water applications, the choke line frictional pressure losses are normally evaluated and can also be included, but in operations onshore or in shallow waters these frictional pressure losses are often excluded. Annulus friction pressure losses are often neglected entirely because they are considered insignificant or considered to be an extra safety factor.
Conventional well control procedures normally start the kick circulation by ramping up the pumps to speed while keeping the choke pressure constant. This procedure implies that any frictional pressure losses in the annulus and choke lines will be added to the wellbore pressure (considered a "nice to have" safety margin). An additional safety margin may be applied before starting the actual circulation, by pumping a few strokes into the shut in well to give some additional overpressure. This additional pressure does not represent a problem if it is accounted for in the planning phase, but, if not considered it could impose a risk to the operation if the actual kick tolerance in the operation is less than the calculated. In deep wells, typically with high mud density, the frictional pressure losses in the annulus can be significant, also at the slow circulation rates during a kick circulation. The standard safety margin applied in planning may or may not match this reality.