bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Technological Performance of Soft Wheat Flours for Fresh-Pasta Production as Affected by Industrial Refining Degree
Authors: Iacovino S. , Garzon R. , Rosell C. M. , Marconi E. , Albors A. , Martín-Esparza M. E. 
Published: October 2024

Abstract
Nowadays, whole grain and less refined flours deriving from higher extraction rate milling processes have received much attention due to the presence of the external parts of the grain constituting the bran, with well-known health benefits. The use of these flours can represent a rational option for the valorization of native bran with minimal by-product generation while improving the nutritional and functional profile of the end products. This work aims to evaluate the techno-functional characteristics of commercial soft wheat flours with different refining degrees (proximate composition, functional, rheological, and starch-related properties) and their relation to the produced fresh-pasta quality (cooking behavior, mechanical and optical properties, and sensory assessment). Specifically, water holding capacity, fat absorption capacity, and swelling ability of flours gradually decreased with the refining degree (up to 25%, 16%, and 36%, respectively). Regarding the starch properties, the overall gelatinization process resulted to be negatively influenced by higher extraction rates, leading to a lower consistency of the whole grain starch gels (~17% in the maximum force during heating and ~12.39% peak viscosity). Cooked pasta was darker and redder when increasing the extraction rate. In addition, whole grain-based pasta had 42% higher cooking loss, and it was 86% harder and 101% firmer, leading to the production of a less elastic fresh-pasta with lower swelling ability. However, a good quality end product with naturally high nutritional value can be produced with flours with low refining degree. Results are useful to assess the best productive destination of flours basing on their technological properties.
Exploring circulation dynamics in Han Dynasty China: insights from isotopic analysis of lead glazed pottery
Authors: Wang Chen , De Ceuster Sarah , Eremin Katherine , Laursen Sarah , Degryse Patrick 
Published: October 2024

AbstractThis study investigates lead provenance and circulation patterns in Han Dynasty (202BC-220AD) China through the analysis of lead glazed pottery. Four objects were studied using a combination of typological study, elemental chemistry and lead isotope ratio analysis. The results for each object were compared with databases of ‘lead mining districts’ (lead deposits) and ‘lead usage districts’ (lead-containing artifacts unearthed in different spatial and temporal ranges) to assess the lead sources used for each sample and offers a spatial-temporal range of the use of these lead resources. Three distinct groups of lead and their possible circulating spatial-temporal scales are identified across six samples in this study. A possible change in lead supply networks between the Western Han Dynasty (202BC-9AD) and the Eastern Han Dynasty (25AD-220AD) is proposed. This study also highlights the probable changes in the movement of lead resources from the Western Han Dynasty to the Tang Dynasty (618AD-690AD), suggesting improvements in long-distance transport capabilities, and the development of economic divisions and exchange connections in ancient Chinese society. Our findings contribute to a deeper understanding of the economic and political dynamics during the Han Dynasty and emphasize the significance of lead isotope analysis of glazed pottery in exploring resource movement.
Integrative analysis of bulk and single-cell transcriptomic data reveals novel insights into lipid metabolism and prognostic factors in hepatocellular carcinoma
Authors: Qi Feiyu , Zha Guiming , Zhang Yanfang , Liu Sihua , Yang Yuhang , Sun Wanliang , Wang Dongdong , Liu Zhong , Lu Zheng , Zhang Dengyong 
Published: October 2024

AbstractHepatocellular carcinoma (HCC) is associated with high mortality rate. This study investigated the status of lipid metabolism-related genes in HCC. Bulk transcriptomic and single-cell sequencing data for HCC were retrieved from public databases. The single-cell sequencing data was subjected to dimensionality reduction, which facilitated the annotation of distinct cell subpopulations and marker gene expression analysis within each subpopulation. Genes associated with lipid metabolism in liver cells were identified, and a machine-learning model was developed using the bulk transcriptomic data randomly partitioned into training and validation sets. The efficacy of the model was validated using these two sets. A multifactorial Cox analysis on the model genes combined with clinical features, led to the identification of age, HMGCS2, HNRNPU, and RAN as independent prognostic factors, which were included in the nomogram model construction and validation. A weighted gene co-expression analysis of all genes of the bulk transcriptome samples revealed the correlation between gene modules and risk score. Genes with cor > 0.4 in the highest-expressing module were selected for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analysis. Immune-related analysis was conducted based on seven algorithms for immune cell infiltration prediction. For the genes in the nomogram model, the expression in clinical pathological factors was also analyzed. The drug sensitivity analysis offered a reference for the selection of targeting drugs. This investigation provides novel insights and a theoretical basis for the prognosis, treatment, and pharmaceutical advancements for patients diagnosed with HCC.
Enhancing bevacizumab efficacy in a colorectal tumor mice model using dextran-coated albumin nanoparticles
Authors: Pangua Cristina , Espuelas Socorro , Simón Jon Ander , Álvarez Samuel , Martínez-Ohárriz Cristina , Collantes María , Peñuelas Iván , Calvo Alfonso , Irache Juan M. 
Published: October 2024

AbstractBevacizumab is a monoclonal antibody (mAb) that prevents the growth of new blood vessels and is currently employed in the treatment of colorectal cancer (CRC). However, like other mAb, bevacizumab shows a limited penetration in the tumors, hampering their effectiveness and inducing adverse reactions. The aim of this work was to design and evaluate albumin-based nanoparticles, coated with dextran, as carriers for bevacizumab in order to promote its accumulation in the tumor and, thus, improve its antiangiogenic activity. These nanoparticles (B-NP-DEX50) displayed a mean size of about 250 nm and a payload of about 110 µg/mg. In a CRC mice model, these nanoparticles significantly reduced tumor growth and increased tumor doubling time, tumor necrosis and apoptosis more effectively than free bevacizumab. At the end of study, bevacizumab plasma levels were higher in the free drug group, while tumor levels were higher in the B-NP-DEX50 group (2.5-time higher). In line with this, the biodistribution study revealed that nanoparticles accumulated in the tumor core, potentially improving therapeutic efficacy while reducing systemic exposure. In summary, B-NP-DEX can be an adequate alternative to improve the therapeutic efficiency of biologically active molecules, offering a more specific biodistribution to the site of action.
Graphical abstract
Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study
Authors: Lorincz Balazs , Vrablik Michal , Murali Ramanathan , Havrdova Eva Kubala , Horakova Dana , Krasensky Jan , Vaneckova Manuela , Uher Tomas 
Published: October 2024

Abstract
Objectives
This study aimed to investigate relationships between cholesterol profile, brain volumetric MRI, and clinical measures in a large observational cohort of multiple sclerosis (MS) patients.

Materials and methods
We included 1.505 patients with 4.966 time points including complete lipid, clinical, and imaging data. The time among lipid, brain MRI and clinical measures was under 90 days. Cross-sectional statistical analysis at baseline was performed using an adjusted linear regression and analysis of longitudinal lipid and MRI measures data was performed using adjusted linear mixed models.

Results
We found associations between higher high-density lipoprotein cholesterol (HDL-C) and lower brain parenchymal fraction (BPF) at cross-sectional analysis at baseline (B = −0.43, CI 95%: −0.73, −0.12, p = 0.005), as well as in longitudinal analysis over follow-up (B = −0.32 ± 0.072, χ2 = 36.6; p = < 0.001). Higher HDL-C was also associated with higher T2-lesion volume in longitudinal analysis (B = 0.11 ± 0.023; χ2 = 23.04; p = < 0.001). We observed a weak negative association between low-density lipoprotein cholesterol (LDL-C) levels and BPF at baseline (B = −0.26, CI 95%: −0.4, −0.11, p = < 0.001) as well as in longitudinal analysis (B = −0.06 ± 0.03, χ2 = 4.46; p = 0.03). T2-LV did not show an association with LDL-C. We did not find any association between lipid measures and disability. The effect of lipid levels on MRI measures and disability was minimal (Cohen f2 < 0.02).

Conclusions
Our results contradict the previously described exclusively positive effect of HDL-C on brain atrophy in patients with MS. Higher LDL-C was weakly associated with higher brain atrophy but not with higher lesion burden.
Association of biological aging with prostate cancer: insights from the National Health and Nutrition Examination Survey
Authors: Yin Weiqi , Song Baiyang , Yu Chengling , Jiang Junhui , Yan Zejun , Xie Chengxin 
Published: October 2024

AbstractThe link between biological aging and prostate cancer (PCa) risk, particularly as indicated by elevated prostate-specific antigen (PSA) levels, remains uncertain. This study utilized data from the National Health and Nutrition Examination Survey (2001–2010) to explore this association. Biological age was assessed using Klemera-Doubal method age (KDMAge) and phenotypic age (PhenoAge). PCa was identified through self-reported diagnoses, and highly probable PCa was determined by PSA levels. We analyzed the prevalence of PCa and PSA-defined highly probable PCa across quartiles of biological age measures using weighted chi-square and linear trend tests. Associations were evaluated using weighted multiple logistic regression models. Among 7,209 and 6,682 males analyzed, the overall weighted prevalence of PCa was 2.86%, increasing to 9.60% in those aged 65 and above. A significant rise in PCa prevalence was observed with higher quartiles of KDMAge or PhenoAge (P for trend < 0.001), particularly in those under 65. In this younger group, higher PhenoAge acceleration quartiles were linked to increased PCa prevalence and higher risk of PCa (OR = 1.50, P = 0.015) as well as highly probable PCa in those without a diagnosis (OR = 1.28, P = 0.031). These findings suggest that accelerated biological aging is associated with an increased risk of PCa and may indicate early risk as signaled by PSA levels, even in those without a PCa diagnosis.
Estrogen enhances the proliferation, migration, and invasion of papillary thyroid carcinoma via the ERα/KRT19 signaling axis
Authors: Song Z. M. , Wang Y. D. , Chai F. , Zhang J. , Lv S. , Wang J. X. , Xi Y. 
Published: October 2024

Abstract
Background
Estrogen is thought to be the reason for the higher prevalence of papillary thyroid carcinoma (PTC) in fertile women; however, more study is required to completely comprehend how estrogen affects PTC development at the cellular level. Therefore, we combined Oxford Nanopore Technologies (ONT) sequencing to explore molecular markers of PTC and to investigate the molecular mechanisms by which estrogen promotes PTC development.

Methods
The expression levels of ESR1 (ERα) and KRT19 in normal thyroid tissues and cancer tissues as well as in different cancer stages, races, genders, age groups, histological subtypes and nodular metastasis status of the TCGA database were analyzed online by Ualcan; the relationship between ESR1, KRT19 and the survival of THCA patients was analyzed. A PTC xenograft tumor model was established. An ERα specific inhibitor (MPP) was administered and an EDU cell proliferation assay was used to verify the effect of estrogen on PTC proliferation. KRT19 was knocked down in KTC-1 cells, and the proliferation, migration, and invasion abilities of PTC cells were determined using CCK-8, immunofluorescence labeling, Western blot for EMT-related proteins, scratch assay, and Transwell assay. The role of ERα in relation to KRT19 was investigated by Western blot and immunofluorescence. The effects of ERα/KRT19 signaling axis on the proliferation, migration and invasion ability of PTC cells were evaluated using EDU cell proliferation assay and Transwell. Using ONT sequencing, 15 pairs of PTC tissue and paracancer tissue samples were collected. A PPI network was constructed to validate the differential expression of KRT19 in combination with biosignature analysis, and the protein interaction between KRT19 and ESR1 was verified using STRING.

Results
Ualcan showed that the expression of ESR1 and KRT19 was higher in THCA tissues than in normal thyroid tissues. E2 activation of ERα promoted the growth of PTC cells and tissues. si-KRT19 inhibited the proliferation, migration and invasion of PTC cells. KRT19 together with ERα formed the ERα/KRT19 signaling axis. E2 activation of the ERα/KRT19 signaling axis promoted the proliferation, migration, and invasion of PTC cells. ONT sequencing and STRING website verified that KRT19 is significantly differentially expressed in PTC and that ESR1 and KRT19 have protein interactions and are related to the estrogen signaling pathway.

Conclusions
Using public databases, RNA sequencing, and bioinformatics, we discovered that E2 stimulates the ERα/KRT19 signaling axis to stimulate PTC proliferation, migration, and invasion.
Teaching the Basics Brilliantly or Reinforcing Yet Another Subject Hierarchy?
Authors: Wrathall Jade 
Published: October 2024

AbstractThe New Zealand Curriculum is comprised of eight compulsory learning areas: English, the arts, health and physical education, learning languages, mathematics and statistics, science, social sciences, and technology. Collectively, these learning areas are intended to provide children with a broad and balanced education. Despite this, the National-led government have introduced a new education policy titled Teaching the Basics Brilliantly. As this policy is focused exclusively on reading, writing, mathematics, and science, a hierarchy of subjects will likely be reinforced. This article examines the different aspects of the Teaching the Basics Brilliantly policy and discusses the implications of privileging three of the eight learning areas.
‘The Little Things’: The Temporality of Young People’s Strategies for Existential, Grounded, and Expansive Wellbeing in Rural Australia
Authors: Lee Meghan 
Published: October 2024

AbstractThis paper is based on research in rural southeast Australia with young people from recent migrant and refugee backgrounds. While existing research on the wellbeing of this group often emphasises successful settlement through education, employment, and belonging as pathways to future wellbeing, this paper asks what we can learn from young people’s own experiences and understandings of wellbeing. Guided by the words, images, and reflections of young people involved in this research, the paper explores everyday wellbeing as an existential, relational, and situated happening that takes both time and place. Young people in the study highlighted the importance of finding beauty, joy, and connection in ‘the little things’ of daily life to bring a sense of meaning into monotonous temporal rhythms and weekly routines structured by work and study. Drawing from Todres and Galvin’s ‘dwelling-mobility’ wellbeing framework, this paper conceptualises young people’s ability to be well as intricately intertwined with their ability to experience their lives over time as grounded and secure, while also having a sense of greater meaning and possibility. Ultimately, the paper illustrates how young people understand their ability to be well as temporally complex, informed by ongoing, non-linear interactions between past, present, and future experiences as they look forward and back over their lives, seeking to transform the passage of time from meaningless to meaningful.
Waste 4.0: transforming medical waste management through digitalization and automated segregation
Authors: Mohamed Nurul Hamizah , Khan Samir , Jagtap Sandeep 
Published: October 2024

AbstractMedical waste management is a crucial issue due to its potential health risks to humans and harm to the environment. The World Health Organization (WHO) advises separating medical waste into seven groups based on its type. However, despite the implementation of color-coded bin bags, cases of missegregation still occur frequently, leading to injuries and spreading diseases. Infectious waste such as sharps, human tissue, and body parts are often found mixed in waste bins, posing a severe threat to waste employees. To address this issue, this paper proposes exploring the potential of digitalization in waste segregation. The literature on current segregation methods and technology applications is analysed and compared, and a framework for utilizing barcode tagging and scanning to ensure waste is correctly categorized is presented. The barcodes and scanner will be connected through a monitoring system, which can notify waste generators and collectors of misplacing or mixed waste. This digitalization system is expected to serve as a monitoring agent for segregating waste before it is collected from any health facilities. Additionally, the exchanged data from waste generator bins can inform collectors and other waste stakeholders about the waste's condition, potentially opening up opportunities for recycling companies to purchase used plastics or metals from hospital wastes. By implementing digitalization in medical waste management, waste segregation can improve, reduce the spread of diseases and injuries, and promote the recycling of hospital waste materials.
Competing few-body correlations in ultracold Fermi polarons
Authors: Liu Ruijin , Cui Xiaoling 
Published: October 2024

AbstractPolaron, a typical quasi-particle that describes a single impurity dressed with surrounding environment, serves as an ideal platform for bridging few- and many-body physics. In particular, different few-body correlations can compete with each other and lead to many intriguing phenomena. In this work, we review the recent progresses made in understanding few-body correlation effects in attractive Fermi polarons of ultracold gases. By adopting a unified variational ansatz that incorporates different few-body correlations in a single framework, we will discuss their competing effects in Fermi polarons when the impurity and majority fermions have the same or different masses. For the equal-mass case, we review the nature of polaron-molecule transition that is driven by two-body correlations, and especially highlight the finite momentum character and huge degeneracy of molecule states. For the mass-imbalanced case, we focus on the smooth crossover between polaron and various dressed clusters that originate from high-order correlations. These competing few-body correlations reviewed in Fermi polarons suggest a variety of exotic new phases in the corresponding many-body system of Fermi-Fermi mixtures.
Making sense of the interaction between geopolitics and middle-technology trap: evidence from China’s catching-up CNC machine tool industry
Authors: Yuan Haoyan 
Published: October 2024

AbstractThis study proposes a framework to analyze the interaction between geopolitics and the Middle-Technology Trap, drawing on evidence from China's CNC machine-tool industry. Qualitative methods such as interviews have been utilized to identify geopolitical variables that have driven the development of the Chinese CNC machine tools industry. To explore the combined effects of the Middle-Technology Trap and the intense competition between China and the West, this article focuses on an industry that has been significantly influenced by the economic decoupling between China and the US, a phenomenon deeply rooted in recent great power competition. While several industries may illustrate the new status quo of the Middle-Technology Trap, the CNC machine-tool industry is particularly exemplary due to its close interrelation with geopolitics. Accordingly, this study presents a catch-up case that incorporates technology-oriented aspects and factors from strategic competition, underlining three scenarios that geopolitics could influence the result of addresing the Middle-Technology Trap, respectively technological decoupling, the relocation of supply chain, and industrial policy.
God and Purported Logical Arguments from Evil and Suffering
Authors: Sterba James P. 
Published: October 2024

AbstractLogical arguments from evil against the existence of God are the strongest form of arguments from evil. They maintain that the all-good, all-powerful God of traditional theism is logically incompatible with the evil in the world. Given that the most well-known logical argument from evil remains the argument put forward by John Mackie over fifty years ago, I begin by setting out Mackie’s argument in detail as well as Alvin Plantinga’s well-regarded critique of it. I then discuss Mackie’s not well-known confusing response to Plantinga’s critique along with attempts by Hugh LaFollette and Quentin Smith to support Mackie’s argument, which fail to take into account Mackie’s own concession to Plantinga’s critique. I then discuss my own attempt in 2019 to provide a Mackie-style logical argument from evil and the reception it has received. I end by suggesting that further discussion might best be pursued by taking up the related question of whether an objective ethics can by adequately supported without appealing to the existence of the God of traditional theism.
Sinicizing China’s World Muslim City: Spatial Politics, National Narratives, and Ethnoreligious Assimilation in the PRC
Authors: McCarthy Susan K. 
Published: October 2024

AbstractThe nation-state is as much a narrative and ideational project as it is a spatial-territorial one. In the People’s Republic of China, Xi Jinping’s calls to “revitalize” China’s traditional culture, “Sinicize” religions, and “rejuvenate” the Chinese nation reflect a broader effort to reframe the national narrative and strengthen Communist Party control. This article examines the implications of Xi’s revisionist nationalism for China’s fifty-five minority nationalities, in particular the Hui, one of ten Muslim minority groups. It does so by analyzing the rise and demise of World Muslim City (WMC), a development project in western China that mobilized Hui identity and traditions for economic and diplomatic purposes. WMC was facilitated by a multicultural national narrative and by a fragmented authoritarian political system that for many years fostered policy improvisation, and deviation, at the local level. Its suspension underscores the increasingly anti-Muslim, anti-religious tenor of PRC policy, as evidenced by the Sinicization campaign that was a proximate cause of WMC’s demise. Its demise also highlights ongoing efforts to reassert CCP control over government, business, and the Party’s own rank-and-file. The fate of WMC furthermore reveals the spatial dimensions of Sinicization, and of Chinese cultural governance past and present. To paraphrase theorist Henri Lefebvre, Sinicization entails “spatial practices” that impose Xi-ist “representations of space” on lived “representational spaces,” from mosques and businesses to theme parks and luxury resorts.