bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized Trial on the Safety and Efficacy of Endovascular Treatment of Unruptured Intracranial Aneurysms is Feasible
Authors: Raymond J. , Chagnon M. , Collet J-P , Guilbert F. , Weill A. , Roy D. 
Published: January 2017

The safety and efficacy of endovascular treatment of unruptured intracranial aneurysms remain undetermined. A randomized trial may be the best way to demonstrate the potential benefits of endovascular management. We propose a randomized, prospective, controlled trial comparing the incidence of subarachnoid haemorrage of patients treated by endovascular coiling as compared to conservative management. We would also study a composite outcome combining SAH and the morbidity of treatment. All patients with one or more unruptured aneurysm >> 3 mm eligible for endovascular treatment would be proposed to participate. The study would be conducted in 40–50 centres. The entire study would enrol 1800 patients, recruited over three years and followed for five years, but would be preceded by a feasibility study on 200 patients. A randomized trial comparing endovascular and conservative treatment could have an important impact on the clinical management of intracranial aneurysms
Spontaneous Petrous Carotid Artery Occlusive Dissection Treated by Local Fibrinolysis and Stent Deployment
Authors: Villa G. , Cellerini M. , Mangiafico S. , Ammannati F. , Giordano G. P. 
Published: January 2017

This paper reports a case of local thrombolytic therapy followed by stenting of the petrous carotid in a young woman with recurrent transient ischemic attacks from spontaneous dissection. A total of four overlapping balloon-expandable stents were delivered in two different sessions one month apart. The procedure resulted in a potentially efficacious treatment for the prevention or reduction of cerebral damages from ischemia. At follow-up three months later the patient was symptom free and DSA revealed a delayed proximal small pseudoaneurysm and a carotid-cavernous fistula. At one year follow-up the patient was still symptom-free with unmodified findings at cerebral angiography.
Embolization of Cerebral Aneurysms with Spherically Shaped Detachable Microcoils (MicruSphere Microcoil System)
Authors: Lee D.H. , Arat A. , Morsi H. , Jou L-D. , Mawad M.E. 
Published: January 2017

We present our initial experience of concentric-filling technique using MicruSphere 3D coils (Micrus Endovascular, San Jose, CA) in the treatment of intracranial aneurysms. 149 intracranial saccular aneurysms in 142 consecutive patients (mean age 56.6 ± 12.7, ruptured in 54 (36.2%)) were treated with the concentric-filling technique. The mean aneurysm volume was 169.0 ± 363.0 mm3. Neck remodeling technique was used in 120 (80.5%). Procedure-related problems were recorded. Initial embolization results were evaluated, and the coil packing density was calculated. Clinical and angiographic follow-ups were performed after six months. Any changes in embolization status were classified as ‘improved’, ‘unchanged’, or ‘worse’. The overall packing density was 40.1% (range 10.5–90.9%). The permanent morbidity and mortality rates were 4.0% and 1.3%, respectively. The initial Raymond and Roy classification results were class 1 in 37 aneurysms (24.8%), class 2 in 50 (33.6%), and class 3 in 62 (41.6%). On the mean follow-up examination of 8.2 months in 103 patients (72.5%), there were one transient ischemic attack, one minor stroke, and one instance of rebleeding. Angiographic follow-up in 101 aneurysms (67.8%) showed the change in embolization status as ‘improved’ in 42 aneurysms (41.6%), ‘unchanged’ in 42 (41.6%), and ‘worse’ in 17 (recanalisation rate, 16.8%). The concentric-filling technique using Micrusphere 3D coils was effective in achieving high packing density which in turn resulted in stable embolization in the majority of the aneurysms. Longer follow-up is warranted to determine the durability of these results.
Two Cases of a Dural Arteriovenous Fistula Mimicking a Brain Tumor
Authors: Ishihara H. , Ishihara S. , Okawara M. , Suzuki M. , Kanazawa R. , Kohyama S. , Yamane F. , Uchino A. 
Published: January 2017

Dural arteriovenous fistula (d-AVF) is relatively rare. Some cases of atypical locations are often difficult to distinguish from other vascular disorders or tumors because those d-AVFs show various onsets, such as subcortical bleeding and venous infarctions. We encountered two cases of d-AVF with severe brain edema that took adequate time to distinguish from brain tumors. A 68-year-old man visited his local physician complaining of dizziness. He was diagnosed with a cerebral infarction due to the presence of an abnormal cerebellar signal on magnetic resonance imaging (MRI) and was treated by drip infusion. However, he did not recover and was admitted to our hospital with suspicion of a brain tumor. A 75-year-old woman with an onset of progressive dementia and gait disturbance showed severe edema of the right-front temporal lobe on MRI. Both these cases were examined by single photon emission computed tomography or positron emission tomography and were scheduled for craniotomy and biopsy based on the diagnosis of brain tumor. We performed pre-operative angiography and found d-AVFs. We embolized the d-AVFs with liquid material and both patients recovered well. Brain edema from d-AVF or a tumor can be distinguished by carefully reading the MRI with findings such as the distribution of the edemas, differences on diffusion-weighted images, and contrast-enhanced images. Therefore, it is important to provide initial accurate diagnoses to prevent patient mistrust and irreversible disease conditions.
Subcutaneous Hematoma Associated with Manual Cervical Massage during Carotid Artery Stenting
Authors: Tsurumi A. , Tsurumi Y. , Negoro M. , Yokoyama K. , Oheda M. , Susaki N. , Tsugane S. , Takahashi T. , Miyachi S. 
Published: January 2017

We describe a patient with subcutaneous hematoma associated with manual cervical massage during carotid artery stenting. A 73-year-old man with left cervical carotid artery stenosis presented with left amaurosis fugax. We performed carotid artery stenting using distal embolic protection with balloon occlusion. Dual antiplatelet therapy was maintained in the periprocedural period and an anticoagulant agent was administered during the procedure. Because the aspiration catheter became entrapped by the stent, it did not reach the distal side of the stenotic lesion, and manual compression of the cervical region was therefore performed. Immediately afterwards, a subcutaneous hemorrhage occurred in the cervical region. There was no postoperative dyspnea due to enlargement of the hematoma, which was absorbed spontaneously. Cervical subcutaneous hematoma can occur in the cervical region due to cervical massage in patients who are receiving adjuvant antiplatelet therapy and anticoagulation therapy.
Spontaneous Isolated Dural Arteriovenous Fistula of the Cavernous Sinus: Endovascular Approach via the Foramen Ovale
Authors: de Andrade G. Cabral , Alves H.P. , Parente R. , Salvarani C.P. , Clímaco V.M. , Pereira E.R. 
Published: January 2017

The endovascular treatment of spontaneous dural cavernous sinus fistula (DAVF) can be accomplished by arterial approach, just with symptoms relief, or by numerous venous approaches through the inferior petrosal sinus, ophthalmic vein, anterior or posterior intercavernous sinus and facial vein. Our case suggests the approach to the cavernous sinus via the foramen ovale and emissary veins puncture as an alternative when there is no possibility of venous approach conventionally described. A 76-year-old woman presented with right conjunctival hyperemia, exophthalmos, intraocular pressure increasing and visual deficits in a period of six months. Angiographic diagnosis of spontaneous DAVF isolated from the cavernous sinus, Barrow Type C, with exclusive venous drainage through the superior ophthalmic vein. Endovascular treatment was performed under general anesthesia. Attempts to approach the cavernous sinus through the inferior petrosal sinus ipsilateral and contralateral intercavernous, facial vein and pterygoid plexus, as well as by dissection and direct puncture of the superior ophthalmic vein were not possible. An approach to the cavernous sinus was performed by puncturing the foramen ovale, catheterization of the emissary vein of the foramen ovale with occlusion of the fistula with microcoils. There was a symptomatic regression with gradual normalization of intraocular pressure, exophthalmos and conjunctival hyperemia in three months. The approach to the cavernous sinus through the foramen ovale and catheterization of the emissary cranial skull base vein is an exception and should be considered in cases of spontaneous and isolated DAVF not accessible by a conventional approach.
Safety and Feasibility of a Novel Vascular Closure Device in Neurointerventional Procedures
Authors: Taha Ammar , Walsh Ellen K , Wright Kathryn A , Ahmed Iftikhar , Supakul Nucharin , Awwad Eric E , Tejada Juan G. 
Published: January 2017

This retrospective study evaluated the safety and feasibility of a new arterial femoral access closure device in neurointerventional procedures. The study includes all consecutive adult patients who underwent femoral arteriotomy closure with the MynxGrip™ closure device after Neurointerventional procedures performed between June and December 2012. All patients had a follow-up color Doppler ultrasound (US) within 48 hours after the procedure, which was independently interpreted by two experienced radiologists to evaluate for access site complications. Device success/failure, sheath size, ambulation time, and periprocedural complications were recorded. Fifty-five closure devices were deployed in 53 patients. There were 23 (43%) males and 30 (57%) females; age ranged from 22 to 84 years (mean: 52.1 years). Thirty of the 55 procedures (55%) were therapeutic and 25 were diagnostic interventions (45%). Sheath sizes used were 5F in 35 procedures (64%) and 6F in 20 procedures (36%). The right femoral artery was accessed in 51 procedures (93%) and the left in four procedures (7%). There was only one (1.8%) minor periprocedural complication (small hematoma). Hemostasis was successful in 51 of the 55 procedures (93%) with subsequent early ambulation. No device-induced complications associated with serious clinical sequelae were reported. In our small series, the MynxGrip™ femoral access closure device provided a safe and feasible way of closing the femoral artery puncture site after neurointerventional procedures with low minor complication rates and no major complications. Further large prospective randomized trials are necessary to evaluate the efficacy of the device.
Radiation Dose and Image Quality in Neuroangiography: Effects of Increased Tube Voltage, Added X-Ray Filtration and Antiscatter Grid Removal
Authors: Söderman M. , Hansson B. , Axelsson B. 
Published: January 2017

During endovascular treatment the patient may be subject to fluoroscopy for long periods as well as multiple x-ray exposures. The radiation dose to the patient can be considerable, and cause local deterministic effects such as alopecia or even skin burn. The potential carcinogenic effects should also be noted, being especially important in the paediatric population. We measured radiation doses to patients and personnel during neuroendovascular procedures and diagnostic neuroangiography. We also tried to reduce the radiation dose to the patient utilising increased tube voltage, additional primary X-ray filtration and by removing the antiscatter grid in front of the image intensifier, employing air gap technique. We investigated radiation doses to patient and personnel during neuroangiographic procedures and optimized the examination technique with regard to radiation dose with maintained image quality. Radiation exposure to patients and personnel was measured with thermoluminescent dosimeters and permanently mounted KermaDose-Area-Product meters in front of the X-ray tubes during 13 cerebral angiographies and six neuroendovascular procedures. We performed experiments with radiation dose measurements and evaluation of image quality with 80 and 90 kV tube voltage during image acquisition and 75 and 85 kV during fluoroscopy, as well as with different primary X-ray filtration. Images from patient studies acquired with the original grid in front of the image intensifier were compared with images from patient studies acquired with the grid removed and air gap technique (30 cm). Images from patient studies acquired with the original examination technique were compared to images from patient studies acquired with increased x-ray tube voltage, increased x-ray filtering and with the antiscatter grid removed using an airgap as scatter reduction method. Radiation exposure to personnel was very low using standard protective devices. Measurable doses were recorded only on the hands and forehead of the neuroradiologist. Maximum entrance skin dose was about 1 Gy on the side of the patientspatient's forehead during an endovascular procedure. Increasing the tube voltage from 75 to 85 – 85 and 90 kV, exchanging the original 0.5 mm aluminium primary filtration for 0.2 mm copper and removing the antiscatter grid allowed us to reduce entrance skin dose to the patient by 70% with unchanged or slightly improved image quality.
Pre-Operative Angiography and Embolisation of Petroclival Meningiomas
Authors: Masters L.T. , Nelson P.K. 
Published: January 2017

We reviewed our experience of 15 patients with petroclival meningiomas who underwent pre-operative angiography, 11 of whom were embolised in the same session. We analysed our cases to evaluate the variations in vascular supply to these tumours, their potential for embolisation, and the techniques used for their devascularization; as well as associated MRI findings. The petroclival region is vascularised by the basal tentorial arcade. Petroclival meningiomas derive their blood supply from the ICA and ECA branches which form this network, and may also parasitize supply from the vertebrobasilar system. ICA (meningohypophyseal trunk) supply was present in all our patients, and 93% also had ECA contributions (basal tentorial branches of the middle and accessory meningeal arteries, the ascending pharyngeal artery, the artery of foramen rotundum and transmastoid branches of the occipital artery). 47% had pial supply from the vertebrobasilar system. The ECA supply was partly or completely embolised in each of the 11 patients, and the meningohypophyseal contribution in one; there were no complications. Pre-operative angiographic assessment of patients with petroclival meningiomas provides important information for determining the surgical approach, and when combined with embolisation may facilitate a more complete resection of these surgically challenging lesions.
Post-Embolisation Flow Disturbances at the Basilar Tip Triggering the Development of an Arterial Aneurysm
Authors: Rodesch G. , Van Bogaert P. , Szliwowski H. , Baleriaux D. , Brotchi J. 
Published: January 2017

We present the case of an 11-year-old boy with a large intracerebral and intraventricular haemorrhage due to rupture of a left temporal arteriovenous malformation. The child initially presented with severe headaches and meningism, right VIth nerve palsy, right hemianopsia, and expressive aphasia. After stabilization of his neurological status, the patient was embolised in two sessions with acrylic glue (Histoacryl*), obliterating nearly 90% of the nidus, the residual to be considered for gamma-knife radiosurgery. The first session of embolisation had been complicated, during retrieval of the micro-catheter, by an erratic embolus of glue in the basilar artery. The child was kept for 24 hours under heparin anticoagulation in order to avoid any thrombosis, followed by aspirin. His neurological examination remained stable without worsening of his clinical condition. Further angiographic controls demonstrated the patency of the basilar artery itself with remodelling changes at the basilar tip, with preservation of the perforators in this region. Secondary dilatation of the basilar tip with development of an arterial aneurysm was noted three years after the accident, pointing to the importance of flow turbulence and vascular wall weakness in the development of an arterial aneurysm. The clinical follow-up of this patient is 3.5 years; his neurological status is stable with hemianopsia, mild dysphasia and memory difficulties. Further follow-up will be needed in order to determine the therapeutic requirement for the arterial aneurysm.
The Role of Controlled Anticoagulation in Balloon Occluding Vertebral Arteries to Treat Giant Fusiform Aneurysms of the Basilar Artery
Authors: Ling F. , Zhang H. , Wang D. , Li M. , Miao Z. , Song Q. , Hao M. , Li X. 
Published: January 2017

We suggest and discuss the role of controlled anticoagulation therapy after the balloon occlusion of vertebral arteries to treat giant fusiform aneurysms in the basilar trunk. Two cases of giant fusiform aneurysms were treated with balloon occlusion of vertebral arteries. Both of these patients suffered severe brain stem ischaemia. Anticoagulants were used to adjust the PTT to 1.5–2.5 times the normal level to control the formation speed of thrombosis inside the aneurysms. Case 1 was obliged to suspend the anticoagulation therapy one week after occlusion because of digestive tract haemorrhage, and died of severe brain stem ischaemia. On autopsy, the sac of the aneurysm was totally occupied by the thrombus. Two perforating arteries feeding the brain stem arising from the wall of the aneurysm and infarction in the brain stem were found. Case 2 was anticoagulated strictly and progressively improved after three weeks. Anticoagulation was terminated after one month. Follow-up MRI showed the aneurysm had disappeared six months later. Giant fusiform aneurysms in the basilar artery trunk can be treated with the balloon occlusion of vertebral arteries which induces thrombosis in the sac of aneurysm. Controlled anticoagulation should be given to slow down the thrombotic obliteration in the perforators arising from the aneurysm wall to the brain stem and give the brain stem have enough time to establish the sufficient collateral circulation.
Multifocal Cerebral Fusiform Aneurysms in Children with Immune Deficiencies Report of Four Cases
Authors: Sedat J. , Alvarez H. , Rodesch G. , Lasjaunias P. 
Published: January 2017

We describe three children infected by the human immunodeficiency virus (HIV 1), and one child suffering from familial mucocutaneous candidiasis, who all had multiple, fusiform subarachnoid intracranial aneurysms. Because infectious causative agents were never detected at the level of the lesions, a classical “mycotic” origin of these aneurysms seemed unlikely. Despite the fact that these aneurysms have the same angiographic appearance, they have different etiologies (immune and infectious). These data open the discussion on the reciprocal role of an infectious or immune initial trigger acting on a vascular (endothelial) target. The specificities of the target in terms of location and response enhance specific topographic characteristics (phenotypes) of the cerebral vasculature.
Diagnosing central lesions of the triangular fibrocartilage as traumatic or degenerative: a review of clinical accuracy
Authors: Löw S. , Erne H. , Pillukat T. , Mühldorfer-Fodor M. , Unglaub F. , Spies C. K. 
Published: January 2017

This study examined the reliability of surgeons’ estimations as to whether central lesions of the triangular fibrocartilage complex were traumatic or degenerative. A total of 50 consecutive central triangular fibrocartilage complex lesions were independently rated by ten experienced wrist surgeons viewing high-quality arthroscopy videos. The videos were reassessed after intervals of 3 months; at the second assessment surgeons were given the patient’s history, radiographs and both, each in a randomized order. Finally, the surgeons assessed the histories and radiographs without the videos. Kappa statistics revealed fair interrater agreement when the histories were added to the videos. The other four modalities demonstrated moderate agreement, with lower Kappa values for the assessment without videos. Intra-rater reliability showed fair agreement for three surgeons, moderate agreement for two surgeons and substantial agreement for five surgeons. It appears that classification of central triangular fibrocartilage complex lesions depends on the information provided upon viewing the triangular fibrocartilage complex at arthroscopy. Level of evidence: II
Salvage therapy using self-expandable metal stents for recalcitrant anastomotic strictures after living-donor liver transplantation
Authors: Jang Sung Ill , Sung Se Yong , Park Hyunsung , Lee Kwang-Hun , Joo Seung-Moon , Lee Dong Ki 
Published: January 2017

Background: Recently, there has been an increase in clinical success rates using nonsurgical methods to resolve anastomotic biliary strictures (ABSs) that develop after liver transplantation (LT). However, some strictures are particularly refractory and cannot be completely resolved by an endoscopic or percutaneous procedure. Consequently, the aim of this study was to examine the feasibility and efficacy of using a newly designed fully covered self-expandable metal stent (FCSEMS) to resolve refractory ABS. Methods: A total of 35 patients with an ABS that developed after LT, but could not be resolved by an endoscopic or percutaneous procedure, were included in this study. FCSEMSs were positioned endoscopically and removed after 2–3 months. After stent removal, the patients were followed to assess complications, including re-stenosis. Results: The mean period from LT to stricture was 13.7 months, and the mean duration of the stricture was 31.8 months. The type and mean number of procedures previously attempted were endoscopic retrograde cholangiopancreatography (ERCP) (9.1 ± 5.1) in 19 patients and percutaneous transhepatic biliary drainage (9.2 ± 4.8) in 16 patients. All patients had successful FCSEMS insertions and removals; the mean stent indwelling time was 3.2 months. The mean follow-up period was 18.7 months (range: 6.4–37.8 months). Stricture recurrence was observed in 6 of 29 patients (recurrence rate: 20.7%). The anastomotic stricture resolved with the FCSEMS insertion in 29 of 35 patients (clinical success rate: 82.9%). Conclusions: The newly designed FCSEMS is a potentially feasible and effective treatment for anastomotic strictures that develop after LT but are not amenable to treatment by conventional procedures.
Obesogenic environments: current evidence of the built and food environments
Authors: Townshend Tim , Lake Amelia 
Published: January 2017

Aims: Obesity is one of the most significant global health and social problems, with rates rising dramatically over the past few decades. While the basic drivers of obesity are obvious (more energy consumed than expended), the causes are multifactorial and complex. A decade ago, it was suggested that exploring the ways in which the built environment influenced physical activity and dietary behaviours might provide fertile ground for investigation. This article overviews current evidence and, in particular, emergent themes that are of significance for the United Kingdom. Methods: This article is based on literature extracted from keyword searching of electronic databases. A timeframe of 2006–2016 was used. Results: In the past decade, the research base has grown significantly; while frustratingly some results are still inconclusive or contradictory, it might be argued enough evidence exists to act upon. Themes such as the importance of the journey to school for young people and the multiple environments in which people spend their time are examples of where real progress has been made in the evidence base. Conclusion: Progress towards real change in policy and practice may seem slow; however, the opportunities afforded for health and planning professionals to work together provide a step towards the whole systems approaches to tackle obesity that are desperately needed.