bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early prediction of clinical benefit of treating ovarian cancer using quantitative CT image feature analysis
Authors: Qiu Yuchen , Tan Maxine , McMeekin Scott , Thai Theresa , Ding Kai , Moore Kathleen , Liu Hong , Zheng Bin 
Published: December 2015

Background In current clinical trials of treating ovarian cancer patients, how to accurately predict patients’ response to the chemotherapy at an early stage remains an important and unsolved challenge. Purpose To investigate feasibility of applying a new quantitative image analysis method for predicting early response of ovarian cancer patients to chemotherapy in clinical trials. Material and Methods A dataset of 30 patients was retrospectively selected in this study, among which 12 were responders with 6-month progression-free survival (PFS) and 18 were non-responders. A computer-aided detection scheme was developed to segment tumors depicted on two sets of CT images acquired pre-treatment and 4–6 weeks post treatment. The scheme computed changes of three image features related to the tumor volume, density, and density variance. We analyzed performance of using each image feature and applying a decision tree to predict patients’ 6-month PFS. The prediction accuracy of using quantitative image features was also compared with the clinical record based on the Response Evaluation Criteria in Solid Tumors (RECIST) guideline. Results The areas under receiver operating characteristic curve (AUC) were 0.773 ± 0.086, 0.680 ± 0.109, and 0.668 ± 0.101, when using each of three features, respectively. AUC value increased to 0.831 ± 0.078 when combining these features together. The decision-tree classifier achieved a higher predicting accuracy (76.7%) than using RECIST guideline (60.0%). Conclusion This study demonstrated the potential of using a quantitative image feature analysis method to improve accuracy of predicting early response of ovarian cancer patients to the chemotherapy in clinical trials.
Process evaluation of a mobile health intervention for people with diabetes in low income countries – the implementation of the TEXT4DSM study
Authors: Van Olmen Josefien , Van Pelt Maurits , Malombo Billy , Ku Grace M , Kanda Dominique , Heang Hen , Darras Christian , Kegels Guy , Schellevis François 
Published: December 2015

Introduction Evidence about mobile health (mHealth) approaches to manage diabetes shows modest effects on outcomes, but little is known about implementation variability. This is a process evaluation of an mHealth intervention to improve diabetes self-management through Short Message Service (SMS) provision in three diabetes care programmes in the Democratic Republic of Congo (DRC), Cambodia and the Philippines. Methods The intervention involved Diabetes Self-Management Support via text messages. The content and process of the intervention is based upon the core principles of diabetes self-management and behaviour theory. In each country, messages were sent by project managers to 240 participants in each country, who were randomly assigned to the intervention group. Contracts were negotiated with national phone providers and open access software was used to send the messages. Participants received a mobile phone and SIM card. We analysed data about the implementation process over a one year period. Results The mean monthly number of messages delivered to recipients’ phones was 67.7% of the planned number in DRC, 92.3% in Cambodia and 83.9% in the Philippines. A telephone check revealed problems with one-third of the phones, including breakage, loss and cancelled subscriptions. The number of people reached at least once was 177 (70.0%) in DRC; 147 (60.7%) in Cambodia; five in the Philippines (2.0%). Those reached each time was 144 in DRC (56.9%), 28 (9.9%) in Cambodia, none in the Philippines. People used their phone more frequently than before the intervention. Discussion Implementation of the intervention meets constraints at every step in the process. Barriers relate to the technology, the context and the participants.
The effects of PCB126 on intra-hepatic mechanisms associated with non alcoholic fatty liver disease
Authors: Boucher Marie-Pier , Lefebvre Caroline , Chapados Natalie Ann 
Published: December 2015

Abstract
Background
Non alcoholic fatty liver disease (NAFLD) results from alteration in lipid synthesis and elimination mechanisms such as very-low density lipoprotein (VLDL) production and de novo lipogenesis. Persistent organic pollutants (POPs) are chemicals that were mostly used historically as pesticides, solvents, flame retardant, and other applications. Among POPs, polychlorinated biphenyls (PCB) have been recognized to be of environmental and potential toxicologic concerns. Specifically, PCB126 could act as endocrine disruptors and has recently been associated with hepatic fat accumulation. The purpose of the study was to investigate the effects of PCB126 on the molecular development of NAFLD using hepatocyte and rat models.

Methods
Hepatocytes were exposed to PCB 126 for 72 h and lipid accumulation in cells was quantified by Oil-Red-O. Rats were injected with a single dose of PCB126 or vehicle. Seven days later, liver triglycerides (TAG) content was measured along with protein quantification of hepatic microsomal triglyceride transfer protein (MTP), sterol regulatory element-binding protein 1c (SREBP1c) and diacylglycerol O-acyltransferase 2 (DGAT-2).

Results
Exposure to PCB126 resulted in significant increases of lipid accumulation in hepatocytes (38 %, P <0.05) and hepatic TAG concentrations (64 %, P <0.001) in rats compared to respective control groups. Rats with fatty livers depicted lower MTP (40 %, P <0.02), higher SREBP1c (27 %, P < 0.05) and DGAT-2 (120 %, P < 0.02) protein content levels compared to Placebo group in rats.

Conclusions
It seems that exposure to PCB126 has an important emerging role in the pathophysiology of NAFLD by 1) altering elimination mechanisms such as VLDL synthesis and secretion, through MTP; and 2) increasing hepatic TAG synthesis mechanisms through DGAT 2 and SREBP1c.
Climate for Culture: assessing the impact of climate change on the future indoor climate in historic buildings using simulations
Authors: Leissner Johanna , Kilian Ralf , Kotova Lola , Jacob Daniela , Mikolajewicz Uwe , Broström Tor , Ashley-Smith Jonathan , Schellen Henk L. , Martens Marco , van Schijndel Jos , Antretter Florian , Winkler Matthias , Bertolin Chiara , Camuffo Dario , Simeunovic Goran , Vyhlídal Tomáš 
Published: December 2015

Abstract

Background
The present study reports results from the large-scale integrated EU project “Climate for Culture”. The full name, or title, of the project is Climate for Culture: damage risk assessment, economic impact and mitigation strategies for sustainable preservation of cultural heritage in times of climate change. This paper focusses on implementing high resolution regional climate models together with new building simulation tools in order to predict future outdoor and indoor climate conditions. The potential impact of gradual climate change on historic buildings and on the vast collections they contain has been assessed. Two moderate IPCC emission scenarios A1B and RCP 4.5 were used to predict indoor climates in historic buildings from the recent past until the year 2100. Risks to the building and to the interiors with valuable artifacts were assessed using damage functions. A set of generic building types based on data from existing buildings were used to transfer outdoor climate conditions to indoor conditions using high resolution climate projections for Europe and the Mediterranean.

Results
The high resolution climate change simulations have been performed with the regional climate model REMO over the whole of Europe including the Mediterranean region. Whole building simulation tools and a simplified building model were developed for historic buildings; they were forced with high resolution climate simulations. This has allowed maps of future climate-induced risks for historic buildings and their interiors to be produced. With this procedure future energy demands for building control can also be calculated.

Conclusion
With the newly developed method described here not only can outdoor risks for cultural heritage assets resulting from climate change be assessed, but also risks for indoor collections. This can be done for individual buildings as well as on a larger scale in the form of European risk maps. By using different standardized and exemplary artificial buildings in modelling climate change impact, a comparison between different regions in Europe has become possible for the first time. The methodology will serve heritage owners and managers as a decision tool, helping them to plan more effectively mitigation and adaption measures at various levels.
Retrospective Analysis of the Predictive Factors of Renal Function Loss after Uninephrectomy in Patients with Chronic Kidney Disease G3 to G5
Authors: Dupuis Dominique , Ouellet Georges , Roy Louise 
Published: December 2015

Background: The rapid increase in glomerular filtration rate in a normal contralateral kidney after uninephrectomy is well known in living kidney donors but much less well described in chronic kidney disease (CKD). The purpose of this study is to determine the magnitude of this initial compensatory capacity in (CKD) groups 3 to 5 (G3 to G5) patients undergoing uninephrectomy and the clinical factors predicting it. This is a retrospective study of all cases (142) of uninephrectomy in patients with estimated glomerular filtration rate (eGFR; with MDRD equation) <60 ml/min/1.73 m2, between 2003 and 2010, in two University of Montreal-affiliated teaching hospitals. Methods: Baseline eGFR, patients' comorbidities, and surgical characteristics and complications were noted. The change of eGFR after nephrectomy was evaluated; moreover, the expected post-op eGFR, i.e. without compensation by the contralateral kidney following surgery, was estimated in a sub-group of patients who had a preoperative renal scintigraphy and compared to the actual eGFR at hospital discharge. Results: The mean change of eGFR from baseline to hospital discharge was −5 ± 12 ml/min/1.73 m2 (–11 %; 95 % CI −16 to −6 %; P < 0.001). In univariate and multivariate analyses, baseline eGFR did not influence significantly these results. However, in the multivariate model, radical nephrectomy vs. partial nephrectomy and preoperative hypertension predicted a worse renal outcome. In the sub-group of patients with preoperative renal scintigraphy, the actual eGFR at hospital discharge was also higher than expected from the renal split function (13 ml/min/1.73 m2; 95 % CI 10 to 16; P < 0.001). Conclusions: After uninephrectomy, the contralateral kidney in patients with CKD G3 to G5 still has a clinically significant initial compensatory capacity. The compensation is statistically smaller if the patient had hypertension or a radical uninephrectomy. This initial compensation is rapid and most probably haemodynamic (hyperfiltration). However, most of the included patients had a CKD G3, limiting the strength of the conclusion for the G4 toG5 patients; the length of observation covers the early postoperative period, i.e. less than 2 weeks, in more than half of the cohort.
High-quality permanent draft genome sequence of Ensifer medicae strain WSM244, a microsymbiont isolated from Medicago polymorpha growing in alkaline soil
Authors: Ardley Julie , Tian Rui , O’Hara Graham , Seshadri Rekha , Reddy T. B. K. , Pati Amrita , Woyke Tanja , Markowitz Victor , Ivanova Natalia , Kyrpides Nikos , Howieson John , Reeve Wayne 
Published: December 2015

AbstractEnsifer medicae WSM244 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago species. WSM244 was isolated in 1979 from a nodule recovered from the roots of the annual Medicago polymorpha L. growing in alkaline soil (pH 8.0) in Tel Afer, Iraq. WSM244 is the only acid-sensitive E. medicae strain that has been sequenced to date. It is effective at fixing nitrogen with M. polymorpha L., as well as with more alkaline-adapted Medicago spp. such as M. littoralis Loisel., M. scutellata (L.) Mill., M. tornata (L.) Mill. and M. truncatula Gaertn. This strain is also effective with the perennial M. sativa L. Here we describe the features of E. medicae WSM244, together with genome sequence information and its annotation. The 6,650,282 bp high-quality permanent draft genome is arranged into 91 scaffolds of 91 contigs containing 6,427 protein-coding genes and 68 RNA-only encoding genes, and is one of the rhizobial genomes sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project proposal.
Smoking cessation support: Indian nursing students' practices, attitudes and perceived barriers
Authors: Poreddi Vijayalakshmi , Gandhi Sailaxmi , Chandra Rama , Wilson Andrew , Math Suresh Bada 
Published: December 2015

Background: Tobacco use is a significant global health issue. Studies that examined nursing students' attitudes towards smoking cessation support were limited from India. Aim: To assess undergraduate nursing students' practices, beliefs, attitudes and perceived barriers towards smoking cessation support. Methods: A cross-sectional descriptive design was adopted among undergraduate nursing students (n=178) using self-reported questionnaires. Results: Findings revealed that a majority (68.5%) of the students inquire about their clients' smoking habits and 78.1% of them advise patients who are smokers about the health effects of smoking. Although student nurses hold positive attitudes in the enthusiasm domain (28.8±7.29), the majority of them lack self-efficacy towards smoking cessation support (14.2±4.70). ‘Patient's lack of motivation’ (89.3%), ‘lack of training/knowledge’ (88.2%) and ‘lack of communication skills’ (77.5%) were the major barriers encountered by the participants during tobacco counselling. Conclusion: The findings suggest that there is an urgent need to include a tobacco-control curriculum at undergraduate level to improve their competency in giving smoking cessation support.
Photoluminescence Emission and Structure Study in ZnO:Ag nanorods
Authors: Lozada Erick Velázquez , Camacho-González G M , Quino-Cerdan J M 
Published: December 2015

<p>Scanning electronic microscopy (SEM) andX ray diffraction (XRD) have been applied to the study of structural and optical properties of ZnOnanocrystals prepared by the ultrasonic spray pyrolysis (USP) at different temperatures. The variation of temperatures and times at the growth of ZnO films permits modifying the ZnO phase from the amorphous to crystalline, to change the size of ZnOnanocrystals (NCs), as well as to vary their photoluminescence spectra. </p>
Remodeling Creation: The July 1922 Issue of Kaebyŏk Magazine
Authors: de Fremery Wayne , Kim Sang Hun 
Published: December 2015

Abstract
Digital reproductions of cultural objects are routinely used as information and/or evidence in a wide variety of studies. Yet, many of the procedures and mechanisms that constitute digital objects are hidden from view. This article documents an experiment designed to reveal what is ordinarily concealed when digital reproductions of textual artifacts are enacted. We describe remodeling an encoded copy of the July 1922 issue of the important Korean colonial-era periodical Kaebyŏk (Creation) hosted on a website administrated by the National Institute of Korean History (NIKH). This was done by generating an alternate visual scheme for the Unicode values used as part of the computational procedures that present the July 1922 issue of Kaebyŏk on the NIKH website. We also document our attempts to account for the patterns that emerged when we remodeled the issue.
This creative engagement with the materials and computational elements of digital texts revealed itself to be a fecund form of literary, textual, and historical critique. Indeed, our experiment generated a number of domain-specific hypotheses about genre, translation, and compositional practice in colonial Korea while raising important questions about studies of culture that bracket either the material or discursive systems of cultural objects from view. A narrow focus on the material-discursive details of a single issue of one periodical brought expansive, largely unexplored fields of investigation into view.
Virtual Space and National Division: Crow’s Eye View: The Korean Peninsula at the Venice Architecture Biennale (2014)
Authors: Lee Sohl 
Published: December 2015

Abstract
How can a visual cultural object represent national division, especially its inherent complexity in spatiotemporal contestations brought by the regurgitating history of antagonistic separation? This article’s central object of analysis is a recent architecture exhibition that conjures what I call “a virtual space of Korean division”—an immersive space of embodiment where visitors can experience a shift in conceptual framework through exposure to the unforeseen relations outside their previously held notions about national division, which, for the Korean peninsula, began in 1945 and solidified in 1953. Titled Crow’s Eye View: The Korean Peninsula, the exhibition was housed in the Korean Pavilion for the occasion of the 2014 Venice Architecture Biennale. As an exhibition that presents Korean modern architecture and urban space, Crow’s Eye View prompts an intervention into the history of Korean division, operating on the spatial fields of embodiment, displacement, and mediation. The visual and spatial analyses of the exhibition include the display tactics, the origin story of the Korean Pavilion in Venice, and the colonial poet Yi Sang’s 1934 visual poem Ogamdo (Crow’s eye view), an eponymous poem from which the curators acquire the exhibition’s conceptual identity. Proposing an alternative to the existing representational frameworks of nationalism and Cold War bipolarity, this article argues that Crow’s Eye View and its virtuality reconfigure national division as a precarious state of being in common despite differences—a state of contingent coexistence and not a unified oneness nor an oppositional separation. In so doing, the exhibition thrusts the spatiotemporality of the Cold War, and the post–Cold War era, into virtual movement.
Shifting Coordinates of Nativist (Hyangt’o) Aesthetics: The Colonial Rural in South Korea’s Literary Film Adaptations
Authors: An Jinsoo 
Published: December 2015

Abstract
This article examines South Korea’s cinematic adaptation of the colonial literature, more specifically the short fiction of nativist (鄕土, hyangt’o) aesthetics. It begins with a brief survey of literary art film (文藝映畵, munye yŏnghwa), which emerged as a film cycle of the 1960s, and raises questions about interpretive issues in reading postcolonial films. In short, I claim that the literary film adaptations of the 1960s show a new, colonial, rural “imaginary” particular to South Korea’s cultural production. On the surface, they appear to register a return to the colonial nativist sensibility. However, they mark a clear shift in focus toward the area of communal interaction and the social dynamics of information sharing. This article attempts to discern and articulate new thematic preoccupations and tendencies as well as their implications to a nationalist view toward the Colonial Period. In addition, it historicizes the cinematic version of nativist aesthetics by relating its development to the larger concern of the cinematic form and the history of colonial representation.
Emerging Roles of SPINK1 in Cancer
Authors: Räsänen Kati , Itkonen Outi , Koistinen Hannu , Stenman Ulf-Håkan 
Published: December 2015

AbstractBACKGROUNDTumor-associated trypsin inhibitor (TATI) was originally isolated from the urine of a patient with ovarian cancer. It was later shown to be produced by many other tumors and several normal tissues. It had earlier been isolated from the pancreas and was hence called pancreatic secretory trypsin inhibitor (PSTI). It belongs to a family of protease inhibitors presently called serine peptidase inhibitor Kazal type (SPINK). In the SPINK family TATI/PSTI is SPINK1, which is the name used in this review.CONTENTIn addition to being a protease inhibitor, SPINK1 also acts as an acute-phase reactant and a growth factor. Furthermore, it has been shown to modulate apoptosis. Overexpression of SPINK1 predicts an unfavorable outcome in several cancers and determination of SPINK1 in serum can be used to identify patients at increased risk of aggressive disease. Thus serum SPINK1 can be used as a prognostic tumor marker. Because SPINK1 acts as a growth factor and an inhibitor of apoptosis in some cancers, it has also been suggested that it can be a therapeutic target in cancer. However, because SPINK1 is the major physiological inhibitor of trypsin, inhibition of SPINK1 may increase the risk of pancreatitis.SUMMARYTaking into account the many functions of SPINK1, assessing the role of SPINK1 in cancer has several potentially important clinical applications ranging from a biomarker to a potential new target for cancer therapy.
LEIS BRASILEIRAS E ATUAÇÃO DOS TRIBUNAIS QUANTO À POSSIBILIDADE DE INDENIZAÇÃO CONTRA DANOS À PRIVACIDADE DO INDIVÍDUO
Authors: De Castro André Giovane , De Oliveira Fornasier Mateus 
Published: December 2015

<p>O presente artigo científico busca analisar a forma como o direito à privacidade, integrante dos direitos da personalidade, encontra-se inserido no ordenamento jurídico brasileiro. Com o advento da Constituição Federal de 1988, os sujeitos receberam atenção especial e, em virtude disso, surge a necessidade de refletir sobre o modo como o sistema judiciário está atendendo às demandas. A partir do método hipotético-dedutivo, com pesquisa doutrinária e jurisprudencial, compreende-se que uma era dominada pela informação merece reflexão acerca do limite de informar e a discussão entre o conflito de liberdade de expressão e privacidade, ambos direitos constitucionais, onde nota-se que os julgadores tendem a priorizar o respeito ao indivíduo. Objetiva-se, pois, constatar a atuação dos tribunais nas causas que versam sobre essa matéria, bem como analisar os textos legais que regulam o direito à privacidade.</p>
Characterizations of symmetric cones by means of the basic relative invariants of homogeneous cones
Authors: Nakashima Hideto 
Published: December 2015

AbstractIn this paper, we give necessary and sufficient conditions for a homogeneous cone Ω to be symmetric in two ways. One is by using the multiplier matrix of Ω, and the other is in terms of the basic relative invariants of Ω. In the latter approach, we need to show that the real parts of certain meromorphic rational functions obtained by the basic relative invariants are always positive on the tube domains over Ω. This is a generalization of a result of Ishi and Nomura [Math. Z. 259 (2008), 604–674].