bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Ru3+-functionalized-NMOF nanozyme as an inhibitor and disaggregator of β-amyloid aggregates
Authors: Luo Wan-Chun , Bao Li-Na , Zhang Yu , Zhang Zi-Tong , Li Xi , Pan Meng-Meng , Zhang Jin-Tao , Huang Kun , Xu Yu , Xu Li 
Published: October 2024

A novel nanozyme based on Ru3+-chelated nanoscale metal organic frameworks (Ru3+-NMOFs) displayed peroxidase-like activity, and employed in inhibiting and disaggregating β-amyloid aggregates both in vitro and in vivo.
Treatment and Outcome Metrics for Speech-Language Pathology Treatment of Upper Airway Disorders: A Systematic Review
Authors: Sandage Mary J. , Morton-Jones Mariah E. , Hall-Landers Rebecca J. , Tucker Jordan G. 
Published: October 2024

Objective:
Clinical treatment strategies and progress metrics for patients with inducible laryngeal obstruction (ILO) and exercise-induced laryngeal obstruction (EILO) have not been systematically applied across clinics. The goals of this review were to identify the intervention strategies used to treat upper airway disorders and determine the clinical metrics by which improvement or resolution of ILO/EILO is determined in clinical studies of speech-language pathology intervention.

Method:
A systematic review was conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Systematic Reviews Checklist. English language, full-text publications were identified through MEDLINE (Ovid), APA PsycINFO, and Web of Science for publications that described clinical outcomes following behavioral treatment for ILO provided by a speech-language pathologist (SLP).

Results:
A total of 238 sources were retrieved, of which 75 were duplicates. Titles and abstracts of 163 were screened, with 22 sources included for full-text review. Citation review yielded nine additional resources. Thirty-one sources were included for data extraction. Most sources described use of respiratory/laryngeal retraining. There was a lack of consistency for clinical and standardized metrics used to evaluate improvement or resolution of upper airway symptoms.

Conclusions:
Behavioral and standardized outcome metrics for evaluating therapy outcomes from SLP behavioral intervention of ILO/EILO are not consistently applied. Clinical metrics standards for clinicians are needed to provide a means to evaluate graded improvement in treatment and changes in health care utilization as well as for training less-experienced clinicians.

Supplemental Material:

https://doi.org/10.23641/asha.27172683
Stochastic optimal power flow framework with incorporation of wind turbines and solar PVs using improved liver cancer algorithm
Authors: Khan Noor Habib , Wang Yong , Habib Salman , Jamal Raheela , Gulzar Muhammad Majid , Muyeen S. M. , Ebeed Mohamed 
Published: October 2024

AbstractThe present study introduces a nature inspired improved liver cancer algorithm (ILCA) for solving the non‐convex engineering optimization issues. The traditional LCA (t‐LCA) inspires from the conduct of liver tumours and integrates biological ethics during the optimization procedure. However, t‐LCA facing stagnation issues and may trap into local optima. To avoid such issues and provide the optimal solution, there are some modifications are implemented into the internal structure of t‐LCA based on Weibull flight operator, mutation‐based approach, quasi‐opposite‐based learning and gorilla troops exploitation‐based mechanisms to enhance the overall strength of the algorithm to obtain the global solution. For validation of ILCA, the non‐parametric and the statistical analysis are performed using benchmark standard functions. Moreover, ILCA is applied to resolve the stochastic renewable‐based (wind turbines + PVs) optimal power flow problem using a modified RER‐based IEEE 57‐bus. The objective of this work is to obtain the minimum predicted power losses and enhance the predicted voltage stability. By incorporation of renewable resources into the modified IEEE57‐bus network can help the system to reduce the power losses from 5.6622 to 3.8142 MW, while the voltage stability is enhanced from 0.1700 to 0.1164 p.u.
Towards the development of offshore wind farms in the Mediterranean Sea: A techno‐economic analysis including green hydrogen production during curtailments
Authors: Travaglini Riccardo , Superchi Francesco , Lanni Francesco , Manzini Giovanni , Serri Laura , Bianchini Alessandro 
Published: October 2024

AbstractBringing floating offshore wind turbines (FOWTs) to a real industrial maturity and reducing the levelized cost of floating wind energy are key to significantly increasing the penetration of renewables in the energy mix of Mediterranean countries, especially if in combination with suitable energy storage systems, such as those involving green hydrogen production. The present study analyses techno‐economic aspects of some of the technologies related to FOWTs and hydrogen production by means of offshore‐generated energy, aiming to evaluate the potential of a floating wind farm integrated with a power‐to‐gas energy storage system in a specific installation site near the Sardinian shores. In comparison to the pioneering studies to date, a more detailed computational model is used, able to account for several critical factors like a better description of metocean conditions, constraints on grid capacity, and a state‐of‐the‐art model to define the farm layout. Concerning hydrogen production, a comparison between the statistical approach, which is commonly used in the field, and a fully time‐dependent method is performed. Proposed results obtained with the statistic and the time‐dependent approach show values ranging between 3.79 and 5.47€/kg, respectively. These outcomes are thought to provide an interesting comparison between different fidelity approaches and realistic reference values for the levelized cost of hydrogen by floating wind in the Mediterranean Sea.
The Monte Carlo Thermal-Physics Coupling Method Based on Functional Expansion Tallies
Authors: An Nan , Gou Yuanhao , Luo Hao , Liu Zhaoyuan , Wang Kan 
Published: October 2024

In the Monte Carlo thermal-physical calculations for nuclear reactors, the precise and effective transfer of data between different meshes is a difficult issue of thermal and physical coupling. Converting two separate meshes and transferring the data is an exceptionally difficult and complex task within the conventional nuclear thermal-physics coupling approach. The newly developed Functional Expansion Tallies (FET) method can obtain the continuous distribution of parameters in the solution space.
By applying FET method to nuclear thermal-physics coupling, the no-mesh continuous fission energy distribution can be obtained, which is suitable for more complex meshes. Additionally, the computational memory can be minimized by substituting the data from numerous mesh power distribution data points with the coefficients of the function.
Ergebnisse einer Befragung orthopädischer
Rehabilitationseinrichtungen zur Umsetzung der Medizinisch-beruflich
orientierten Rehabilitation: Leistungsdiagnostik und
Arbeitsplatztraining
Authors: Bühne David , Hetzel Christian , Elling Mathis , Alles Torsten 
Published: October 2024

Zusammenfassung
Ziel der Studie Wenngleich sich die MBOR insbesondere im Bereich der
Muskel-Skelett-Erkrankungen längst als Bestandteil des rehabilitativen
Versorgungssystems etabliert hat, deuteten auf Routinedaten basierende Studien
auf eine ausgeprägte Heterogenität hin, was die Umsetzung des
MBOR-Anforderungsprofils betrifft. Im Rahmen der vorliegenden Untersuchung wurde
die Realisation des Arbeitsplatztrainings sowie auch der vorgeschalteten
Leistungsdiagnostik nun erstmalig auf Grundlage einer bundesweiten Befragung von
Akteurinnen und Akteuren der MBOR in den Blick genommen.
Methodik 2023 erfolgte eine als Vollerhebung angelegte schriftliche
Befragung von Rehabilitationseinrichtungen mit Zulassung für orthopädische MBOR.
Zum Einsatz kam ein in Anlehnung an das MBOR-Anforderungsprofil entwickeltes
Instrument. 86 der 317 angeschriebenen Einrichtungen beantworteten den
Fragebogen und erfüllten zugleich die Einschlusskriterien (Durchführung von
MBOR-Heilverfahren).
Ergebnisse 67% der Fachabteilungen schilderten, zu Reha-Beginn bei
mindestens 50% der Personen Verfahren der Functional Capacity Evaluation (FCE)
einzusetzen und 70% die regelhafte Durchführung spezifischer Profilvergleiche.
Ferner berichteten 57%, das Arbeitsplatztraining auf Grundlage eines
Profilvergleiches zu gestalten. Das Arbeitsplatztraining selbst wird bei etwa
jeder zweiten Fachabteilung bei mindestens 50% der Personen im Umfang von
mindestens 360 Minuten erbracht. Die Durchführung der FCE-Testungen wie auch des
Arbeitsplatztrainings erfolgt dabei vorrangig durch Ergotherapeutinnen und
Ergotherapeuten.
Schlussfolgerung Leistungsdiagnostik und Arbeitsplatztraining werden
vielfach, jedoch längst noch nicht flächendeckend in Einklang mit dem
MBOR-Anforderungsprofil realisiert. Ein vielversprechender Ansatzpunkt zur
einrichtungsinternen Weiterentwicklung und Optimierung der MBOR liegt in der
Förderung der Interdisziplinarität.
Efficacy of EUS-guided keyhole biopsies in diagnosing subepithelial lesions of the upper gastrointestinal tract
Authors: Verhoeve Sen , Verloop Cynthia , Bruno Marco , Terpstra Valeska , Van Driel Lydi , Perk Lars , Hol Lieke 
Published: October 2024

Abstract
Background and study aims Tissue acquisition is required for diagnosis of subepithelial lesions (SELs). However, obtaining adequate tissue remains challenging. This study investigated an EUS-guided technique using a forceps to create a channel and take multiple biopsies from the center of the lesion, therefore called endoscopic ultrasound-guided keyhole biopsy (EUS-KB).
Patients and methods A retrospective cohort study was conducted in 56 patients with SELs in the upper gastrointestinal tract who were scheduled to undergo EUS-KB. The primary aim was to assess diagnostic yield, defined as the percentage of procedures where EUS-KB resulted in a definitive histopathological diagnosis. Furthermore, factors influencing diagnostic yield were investigated. Additional outcomes included technical success and adverse events.
Results Technical success was achieved in 55 of 60 biopsies (91.7%). EUS-KB provided a diagnosis in 44 of 55 biopsies (80.0%), histology mostly showing gastrointestinal stromal tumor or leiomyoma. The diagnostic yield was not significantly influenced by the size or location of the SEL. Adverse events occurred in one patient (1.7%).
Conclusions EUS-KB is a feasible and safe technique for obtaining a classifying diagnosis for SELs in the upper gastrointestinal tract. It could offer an alternative diagnostic modality, especially in lesions smaller than 20 mm.
Tyrosine Kinase Inhibitor Induced Proteinuria – A
Review
Authors: Gayathri J S. , Krishna S. Swathi , Rakesh M. P. 
Published: October 2024

AbstractTyrosine Kinase inhibitor (TKI) is a class of drugs that interfere with protein
kinasesʼ signal transduction pathways through an array of inhibitory mechanisms.
Tyrosine kinases (TK) have an inevitable role in downstream signal transduction
and the proliferation of tumour cells. Hence, tyrosine kinase inhibitors (TKIs)
are frequently employed as anti-neoplastic agents in the treatment of colon,
breast, kidney, and lung cancers. They can be used as single or combination
therapy with other targeted therapies. It is understood that TKIs pose a risk of
developing proteinuria in some patients as it can primarily result in
dysfunction of the split diaphragm, constriction or blockage of capillary lumens
mediated by the basement membrane, acute interstitial nephritis, or acute
tubular necrosis. This paper reviews the mechanism of action of TKIs, the
pathophysiological mechanism of TKI-induced proteinuria, and its management
Fig. 1
Radiographic Diagnosis of Osteoporotic Vertebral Fracture in Older Women and Men Based on Statistical Probability
Authors: Wáng Yì Xiáng J. 
Published: October 2024

AbstractA radiographic gold standard to distinguish osteoporotic vertebral fractures (VFs) from nonosteoporotic VFs does not exist. Radiographic fracture-shaped vertebral deformity (FSVD) is common among young populations with normal bone strength. FSVD in an older population is called osteoporotic-like vertebral fracture (OLVF) when the FSVD is likely associated with compromised bone strength. For more severe grade deformities or when a vertebra is collapsed, experienced readers can make an osteoporotic VF diagnosis with a high degree of certainty. In milder cases, radiographic osteoporotic VF is often diagnosed based on a high probability rather than an absolute diagnosis. For older women, three nonadjacent minimal grade OLVFs (< 20% height loss), one minimal grade OLVF and one mild OLVF (≥ 20∼25% height loss), or one OLVF with ≥ 25% height loss meets the diagnosis of osteoporosis. For older men, a single OLVF with ≥ 33 to 40% height loss is insufficient to suggest the patient has osteoporosis.
Inflammatory Pseudotumor of the Ulnar Nerve Mimicking a Malignant Peripheral Nerve Sheath Tumor: A Radiologic Puzzle
Authors: Abelkis Eimantas , van Langevelde Kirsten , Doeleman Thom , Groen Justus , Navas Cañete Ana 
Published: October 2024

AbstractInflammatory pseudotumor (IPT) of a peripheral nerve is a rare non-neoplastic tumefactive inflammatory condition, often mimicking malignancy. The etiology of this condition is still unknown. Clinically and radiologically, the lesion can mimic a malignant tumor. This case report represents, as far as we know, the first publication describing the ultrasonography findings and the results of advanced dynamic contrast-enhanced magnetic resonance imaging (MRI) and diffusion-weighted MRI of IPT in a peripheral nerve. Suspicion of this entity on imaging can speed up the definitive diagnosis and potentially avoid overly radical treatment.
Bone Marrow and Metabolic Bone Disease
Authors: Aparisi Gómez Maria Pilar , Bazzocchi Alberto 
Published: October 2024

AbstractThe bone marrow represents one of the largest organs in the body, with a relevant metabolic role that continues to be investigated. Numerous studies have focused on marrow adipose tissue (MAT). Evidence indicates that the bone marrow adipocytes do not only work as storage tissue but also consist of endocrine and paracrine cells, with the potential to contribute to local and systemic metabolism. MAT plays a role in bone health through its interaction with the other components of bone. Many metabolic disorders (osteoporosis, obesity, diabetes) have a complex and still not well-established or understood relationship with bone health. This article surveys the literature on the relationship of bone marrow and metabolic disorders, and how it is being studied using imaging techniques, with a special focus on bone health.
Update on Quantitative Computed Tomography
Authors: Cheng Xiaoguang , Wang Ling , Blake Glen M. , Guglielmi Giuseppe 
Published: October 2024

AbstractQuantitative computed tomography (QCT) has important technical advantages for the measurement of bone mineral density, and the technique is well suited for both the diagnosis of osteoporosis and the monitoring of treatment. Its use deserves a wider application than at present. The use of QCT in both research and in the clinic has recently garnered increasing attention. In this review, we update the advances and application of QCT in the study of osteoporosis.
Opportunistic Screening of Bone Fragility Using Computed Tomography
Authors: Acevedo Julian B. Herrera , Lenchik Leon , Weaver Ashley A. , Boutin Robert D. , Wuertzer Scott 
Published: October 2024

AbstractOpportunistic screening uses existing imaging studies for additional diagnostic insights without imposing further burden on patients. We explore the potential of opportunistic computed tomography (CT) screening for osteoporosis, a condition affecting 500 million people globally and leading to significant health care costs and fragility fractures. Although dual-energy X-ray absorptiometry (DXA) remains the gold standard for diagnosing osteoporosis, > 50% of fractures occur in individuals not screened previously with DXA. With recent advancements in technology, CT has emerged as the most promising tool for opportunistic screening due to its wide use and the ability to provide quantitative measurements of bone attenuation, a surrogate of bone mineral density. This article discusses the technical considerations, calibration methods, and potential benefits of CT for osteoporosis screening. It also explores the role of automation, supervised and unsupervised, in streamlining the diagnostic process, improving accuracy, and potentially developing new biomarkers of bone health. The potential addition of radiomics and genomics is also highlighted, showcasing the synergy between genetic and imaging data for a more comprehensive understanding of osteoporosis pathophysiology and with it possible novel osteoporosis therapies. The future of opportunistic CT screening holds significant promise, with automation and advanced image processing ultimately enhancing patient care, reducing rates of osteoporotic fractures, and improving patient outcomes.
Role of Advanced Magnetic Resonance Imaging in Differentiating among Glioma Subtypes and Predicting Tumor-Proliferative Behavior
Authors: Ganesan Gunalan , Rangasami Rajeswaran , Chandrasekharan Anupama , Marreddy Sahithi , Ramachandran Rajoo 
Published: October 2024

Abstract
Objective Gliomas are a devastating and heterogeneous group of primary brain tumors. Previously, the source of glioma was undetermined. Recent literature indicates that neural stem cells, or progenitors, are proposed to be the source of glioma. The prognosis of different types of gliomas differs due to their various biological tissue types. Besides the histological grade, the two useful immunohistochemistry markers that show the tumor's biological behavior are isocitrate dehydrogenase (IDH) labeling and the Ki-67 labeling index. We sought to determine the magnetic resonance imaging (MRI) characteristics associated with IDH mutational status and ascertain whether MRI combined with IDH mutational status, can better predict the clinical outcomes of gliomas.
Materials and Methods This period study was conducted in the Department of Radiology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India for 5 years (May 2016–May 2021). The study cohort included 30 patients diagnosed with gliomas who underwent preoperative MRI followed by surgical resection and histopathological examination. Preoperative MRI images were done to assess qualitative tumor characteristics such as location, margin of tumor, extent, cortical involvement, cystic component, mineralization or hemorrhage, and contrast enhancement.
Discussion Differences in MRI features between IDH-mutant (MT) and IDH-wild-type (WT) groups were analyzed using the chi-square test for categorical variables and the Mann–Whitney U test for continuous variables. Statistical analysis was conducted using SPSS software.
Results Among the 30 patients evaluated, 18 had IDH-WT and 12 had IDH-MT type gliomas. Male predominance (73.33%) was noted in our study. Brainstem location, indistinct borders (83.33%), less cortical involvement (72.22%), less cystic changes (88.89%), more area of necrotic component (44.44%), significantly increased choline/creatine (Cho/Cr) ratio, and choline/N-acetyl aspartate (Cho/NAA) ratio favors IDH-WT tumors. Positive T2-fluid-attenuated inversion recovery mismatch sign is more frequently seen in IDH-MT (7/12; 58.33%) tumors than in IDH-WT (4/18; 22.22%) tumors. Whereas well-defined contours (66.67%), more cortical involvement (83.33%), more cystic changes (58.33%), and less area of necrotic component favor IDH-MT type tumors.
Conclusion MRI is a very promising and valuable tool for differentiating among glioma subtypes and predicting tumor-proliferative behavior in glioma cases. The combination of MRI characteristics with IDH mutation status enhances the predictive accuracy for clinical outcomes in glioma patients. This approach could potentially guide treatment planning and improve prognostic assessments.
Hereditary Transthyretin Amyloidosis Polyneuropathy
Authors: Qarni Taha , Moshe-Lilie Orly , Kaku Michelle C. , Karam Chafic 
Published: October 2024

AbstractIn the last decade, we have witnessed dramatic improvements in the diagnosis, workup, management, and monitoring of patients with hereditary transthyretin amyloidosis (ATTRv). Updated imaging techniques (e.g., 99mTc-PYP scan) are increasingly being used in place of tissue biopsies for confirmation of disease. Novel treatments now include antisense oligonucleotide and RNA interference drugs, whereas new applications such as CRISPR and amyloid antibodies are being studied for potential use in the future. These treatments have dramatically improved quality of life and increased survival in patients with ATTRv. Despite these breakthroughs, many challenges remain. Some of these challenges include early recognition and diagnosis of ATTRv, monitoring and initiation of treatment in asymptomatic or paucisymptomatic carriers, adequate treatment in people with mixed phenotype (i.e., cardiac and neurological), and the emergence of new phenotypes in people living longer with the disease (i.e., central nervous system and ocular complications). Research in those areas of deficit is ongoing, and in the future, we may have preventive therapies, better biomarkers, more efficient therapies for organs that we cannot currently target, and enhanced diagnostic techniques with the help of novel imaging techniques and artificial intelligence. In this review, we will summarize the current knowledge about polyneuropathy related to ATTRv and its management, discuss methods to improve early diagnosis and monitoring, and discuss emerging trends.
Less Common Mononeuropathies
Authors: Treidler Simona 
Published: October 2024

AbstractUncommon mononeuropathies are challenging to diagnose as they can mimic joint pathology, radiculopathies, or plexopathies. They are less easily diagnosed due to unfamiliarity with their clinical presentation, knowledge of anatomy, and less commonly used diagnostic studies. A careful history, physical examination, and electrodiagnostic evaluation can help identify these neuropathies in a timely manner to administer the best treatment for resolution of symptoms. Recent advances in ultrasound and magnetic resonance techniques are used to confirm clinical suspicion of peripheral neuropathy by clearly depicting the anatomy and pathology as well as describing findings that mimic mononeuropathy. It is important for neurology, orthopedic, rheumatology, emergency, and primary care physicians to be familiar with less common mononeuropathies.