bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social comparison, competition and teacher–student relationships in junior high school classrooms predicts bullying and victimization☆
Authors: Di Stasio Maria Rosaria , Savage Robert , Burgos Giovani 
Published: November 2016

ABSTRACTThis cross‐sectional research examines how social comparison, competition and teacher–student relationships as classroom characteristics are associated with bullying and victimization among junior high school students in grades 7 and 8 in Canada. The study tests a conceptual model of youth outcomes that highlights the importance of modeling the effects of teaching practices as proximal structural conditions at the classroom level (N = 38) that affect bullying outcomes at the individual level (N = 687). Results of Hierarchal linear modeling (HLM) revealed significant classroom‐level effects in that increased social comparison, competition and teacher–student relationships were related to bullying and victimization. An interaction for teacher–student relationships and gender also emerged. These findings may guide future intervention programs for junior high schools that focus on enhancing cooperation and pro‐social behavior in classrooms. The findings could also inform programs that focus on building strong relationships between students and teachers to help prevent bullying and victimization, particularly among boys.
Modified meta-heuristics using random mutation for truss topology optimization with static and dynamic constraints
Authors: Savsani Vimal J. , Tejani Ghanshyam G. , Patel Vivek K. , Savsani Poonam 
Published: November 2016

AbstractIn this paper, simultaneous size and topology optimization of planar and space trusses subjected to static and dynamic constraints are investigated. All the benchmark trusses consider discrete cross-sectional areas to consider the practical aspect of manufacturing. Moreover, Trusses are considered with multiple loading conditions and subjected to constraints for natural frequencies, element stresses, nodal displacements, Euler buckling criteria, and kinematic stability conditions. Truss topology optimization (TTO) can be accomplished by the removal of superfluous elements and nodes from the highly hyper static truss also known as the ground structure and results in the saving of the mass of the truss. In this method, the difficulties arise due to the singular solution and unnecessary analysis; therefore, FEA model is reformed to resolve these difficulties.The static and dynamic responses to the TTO problems are challenging due to its search space, which is implicit, non-convex, non-linear, and often leading to divergence. Modified meta-heuristics are effective optimization methods to handle such problems in actual fact. In this paper, modified versions of Teaching–Learning-Based Optimization (TLBO), Heat Transfer Search (HTS), Water Wave Optimization (WWO), and Passing Vehicle Search (PVS) are proposed by integrating the random mutation-based search technique with them. This paper compares the performance of four modified and four basic meta-heuristics to solve discrete TTO problems.Highlights Modifications in four different recently developed meta-heuristics. Use of random mutation based strategy. Implementation on challenging/benchmark truss topology optimization problems. Modifications effective over basic algorithms.
Effect of Botulinum Toxin on Disabling Neuropathic Pain: A Case Presentation Suggesting a New Therapeutic Strategy
Authors: Buonocore Michelangelo , Demartini Laura , Mandrini Silvia , Dall'Angelo Anna , Dalla Toffola Elena 
Published: November 2016

AbstractThis case presentation describes a 47‐year‐old woman who developed complex regional pain syndrome type II with severe neuropathic pain following iatrogenic transection of the tibial nerve at the ankle. The pain and disability progressively worsened over time, markedly impaired ambulation, and were not relieved despite various analgesic treatments. After injection of botulinum toxin (abobotulinumtoxinA, BoNT‐A) in the leg muscles the tendons of which pass through the tarsal tunnel (together with the tibial nerve), her pain decreased and her walking capacity improved. This case suggests a new therapeutic role for botulin toxin in treating peripheral neuropathic pain caused by movement‐evoked ectopic potentials.Level of EvidenceV
Turbulence modifications induced by the bed mobility in intense sediment-laden flows
Authors: Revil-Baudard T. , Chauchat J. , Hurther D. , Eiff O. 
Published: November 2016

An experimental dataset of high-resolution velocity and concentration measurements is obtained under intense sediment transport regimes to provide new insights into the modification of turbulence induced by the presence of a mobile sediment bed. The physical interpretation of the zero-plane level in the law of the wall is linked to the bed-level variability induced by large-scale turbulent flow structures. The comparison between intrinsic and superficial Reynolds shear stresses shows that the observed strong bed-level variability results in an increased covariance between wall-normal ($w^{\prime }$) and streamwise ($u^{\prime }$) velocity fluctuations. This appears as an additional Reynolds shear stress in the near-wall region. It is also observed that the mobile sediment bed induces an increase of turbulence kinetic energy (TKE) across the boundary layer. However, the increased contribution of interaction events ($u^{\prime }w^{\prime }>0$, i.e. quadrants I and III in the ($u^{\prime },w^{\prime }$) plane) induces a decrease of the turbulent momentum diffusion and an increase of the turbulent concentration diffusion in the suspension region. This result provides an explanation for the modification of the von Kármán parameter and the turbulent Schmidt number observed in the literature for intense sediment transport.
Inulin oligofructose attenuates metabolic syndrome in high-carbohydrate, high-fat diet-fed rats
Authors: Kumar Senthil A. , Ward Leigh C. , Brown Lindsay 
Published: November 2016

AbstractPrebiotics alter bacterial content in the colon, and therefore could be useful for obesity management. We investigated the changes following addition of inulin oligofructose (IO) in the food of rats fed either a corn starch (C) diet or a high-carbohydrate, high-fat (H) diet as a model of diet-induced metabolic syndrome. IO did not affect food intake, but reduced body weight gain by 5·3 and 12·3 % in corn starch+inulin oligofructose (CIO) and high-carbohydrate, high-fat with inulin oligofructose (HIO) rats, respectively. IO reduced plasma concentrations of free fatty acids by 26·2 % and TAG by 75·8 % in HIO rats. IO increased faecal output by 93·2 %, faecal lipid excretion by 37·9 % and weight of caecum by 23·4 % and colon by 41·5 % in HIO rats. IO improved ileal morphology by reducing inflammation and improving the density of crypt cells in HIO rats. IO attenuated H diet-induced increases in abdominal fat pads (C 275 (sem19), CIO 264 (sem40), H 688 (sem55), HIO 419 (sem32) mg/mm tibial length), fasting blood glucose concentrations (C 4·5 (sem0·1), CIO 4·2 (sem0·1), H 5·2 (sem0·1), HIO 4·3 (sem0·1) mmol/l), systolic blood pressure (C 124 (sem2), CIO 118 (sem2), H 152 (sem2), HIO 123 (sem3) mmHg), left ventricular diastolic stiffness (C 22·9 (sem0·6), CIO 22·9 (sem0·5), H 27·8 (sem0·5), HIO 22·6 (sem1·2)) and plasma alanine transaminase (C 29·6 (sem2·8), CIO 32·1 (sem3·0), H 43·9 (sem2·6), HIO 33·6 (sem2·0) U/l). IO attenuated H-induced increases in inflammatory cell infiltration in the heart and liver, lipid droplets in the liver and plasma lipids as well as impaired glucose and insulin tolerance. These results suggest that increasing soluble fibre intake with IO improves signs of the metabolic syndrome by decreasing gastrointestinal carbohydrate and lipid uptake.
Association between predominantly plant-based diets and iron status in Chinese adults: a cross-sectional analysis
Authors: He Jingjing , Shen Xin , Fang Aiping , Song Jie , Li He , Guo Meihan , Li Keji 
Published: November 2016

AbstractCurrent evidence of the relationship between diets and Fe status is mostly derived from studies in developed countries with Western diets, which may not be translatable to Chinese with a predominantly plant-based diet. We extracted data that were nationally sampled from the 2009 wave of China Health and Nutrition Survey; dietary information was collected using 24-h recalls combined with a food inventory for 3 consecutive days. Blood samples were collected to quantify Fe status, and log-ferritin, transferrin receptor and Hb were used as Fe status indicators. In total, 2905 (1360 males and 1545 females) adults aged 18–50 years were included for multiple linear regression and stratified analyses. The rates of Fe deficiency and Fe-deficiency anaemia were 1·6 and 0·7 % for males and 28·4 and 10·7 % for females, respectively. As red meat and haem Fe consumption differed about fifteen to twenty times throughout the five groups, divided by quintiles of animal protein intake per 4·2 MJ/d, only Fe status as indicated by log-ferritin (P=0·019) and transferrin receptor (P=0·024) concentrations in males was shown to be higher as intakes of animal foods increased. Log-ferritin was positively associated with intakes of red meat (B=0·3 %, P=0·01) and haem Fe (B=12·3 %, P=0·010) in males and with intake of non-haem Fe in females (B=2·2 %, P=0·024). We conclude that diet has a very limited association with Fe status in Chinese adults consuming a traditional Chinese diet, and a predominantly plant-based diet may not be necessarily responsible for poor Fe status.
Risks to REDD+: potential pitfalls for policy design and implementation
Authors: LOFT LASSE , PHAM THUY THU , WONG GRACE YEE , BROCKHAUS MARIA , LE DUNG NGOC , TJAJADI JANUARTI SINARRA , LUTTRELL CECILIA 
Published: November 2016

SUMMARYInternational negotiations for reducing emissions from deforestation and forest degradation and the enhancement of forest carbon stocks (REDD+) under the UN Framework Convention on Climate Change (UNFCCC) were finally concluded in 2015. However, due to the complex design and implementation processes of REDD+ policies and measures, including benefit sharing at national and subnational levels, several challenges exist for sustainably reducing emissions while simultaneously managing the provision of social and environmental side-objectives. We review the realities of REDD+ implementation in 13 REDD+ candidate countries and the risks related to REDD+ policies and benefit sharing based upon a synthesis of the findings presented in ‘country profiles’ that were developed between 2009 and 2013 as part of the Center for International Forestry Research's (CIFOR) Global Comparative Study on REDD+. We find that REDD+ policies in all countries studied are at high risk of ineffectiveness, inequity and inefficiency. By classifying these risks and understanding not only their impacts on different stakeholder groups, but also the consequences for achieving specific objectives, countries can identify solutions in order to address these shortcomings in their implementation of REDD+.
Non-tuberculous mycobacteria: epidemiological pattern in a reference laboratory and risk factors associated with pulmonary disease
Authors: MENCARINI J. , CRESCI C. , SIMONETTI M. T. , TRUPPA C. , CAMICIOTTOLI G. , FRILLI M. L. , ROGASI P. G. , VELOCI S. , PISTOLESI M. , ROSSOLINI G. M. , BARTOLONI A. , BARTALESI F. 
Published: November 2016

SUMMARYThe diseases caused by non-tuberculous mycobacteria (NTM), in both AIDS and non-AIDS populations, are increasingly recognized worldwide. Although the American Thoracic Society published the guidelines for diagnosis of NTM pulmonary disease (NTM-PD), the diagnosis is still difficult. In the first part of the study, we collected data on NTM isolates in the Mycobacteriology Laboratory of Careggi Hospital (Florence, Italy) and analysed the epidemiological data of NTM isolates. Then, to analyse the risk factors associated to NTM-PD, we studied the presence of ATS/IDSA criteria for NTM-PD in patients who had at least one positive respiratory sample for NTM and were admitted to the Infectious Disease Unit and the Section of Respiratory Medicine. We selected 88 patients with available full clinical data and, according to ATS/IDSA criteria, classified 15 patients (17%) as NTM-PD cases and 73 as colonized patients (83%). When comparing colonized and NTM-PD patients we did not find significant differences of age, gender and comorbidity. We observed that Mycobacterium avium and M. intracellulare were statistically associated with NTM-PD (P = 0·001) whereas M. xenopi was statistically associated with colonization. Although the number of studied patients is limited, our study did not identify risk factors for NTM-PD that could help clinicians to discriminate between colonization and disease. We underline the need of close monitoring of NTM-infected patients until the diagnosis is reasonably excluded. Further larger prospective studies and new biological markers are needed to identify new useful tools for the diagnosis of NTM-PD.
Zur Validität der deutschen Fassung der ADOS-2 unter Berücksichtigung von Geschlechtseffekten
Authors: Kamp-Becker Inge , Langmann Anika , Stehr Thomas , Custodis Katharina , Poustka Luise , Becker Katja 
Published: November 2016

Zusammenfassung. Fragestellung: Die deutschsprachige Version der Diagnostischen Beobachtungsskala für Autistische Störungen – 2 (ADOS-2) ist eine Revision der standardisierten Verhaltensbeobachtung für Personen mit dem Verdacht auf Vorliegen einer Autismus-Spektrum-Störung (ASS). Die Studie untersucht die diagnostische Güte der originalen und revidierten Algorithmen für die Module 1 bis 3. Methodik: An einer großen Inanspruchnahmepopulation (N = 1080, Alter 1.7–20.5 Jahre) wurde die Unterscheidungsfähigkeit der ADOS-2 zu relevanten Differenzialdiagnosen untersucht. Außerdem wurden Vergleiche bezüglich der diagnostischen Güte für beide Geschlechter getrennt vorgenommen. Ergebnisse: Der revidierte Algorithmus weist eine verbesserte Sensitivität (84.9 %) bei jedoch leicht reduzierter Spezifität (85.7 %) auf. Verbesserungen der ADOS-2 betreffen vor allem Fälle von frühkindlichem Autismus und die korrekte Klassifizierung von Mädchen. Der Einschluss von repetitiven, stereotypen Verhaltensweisen in den Algorithmus erhöht die korrekte Klassifikation in den Modulen 2 und 3. Für jüngere Kinder im Modul 1 ist dies jedoch nicht der Fall. Es zeigt sich darüber hinaus eine geringere Differenzierungsfähigkeit zu internalisierenden Störungen und Störungen des Sozialverhaltens. Schlussfolgerungen: Eine gute diagnostische Güte der ADOS-2 wurde vor allem für Kinder mit durchschnittlichen kognitiven Fähigkeiten gefunden. Die Ergebnisse sprechen für eine gute Anwendbarkeit der ADOS-2 für klinische Populationen. Voraussetzung ist jedoch eine sorgfältige und breite Diagnostik durch erfahrene Untersucher. Schlüsselwörter: ADOS, Diagnostik von Autismus-Spektrum-Störungen, Sensitivität, Spezifität
Influence of phylogenetic conservatism and trait convergence on the interactions between fungal root endophytes and plants
Authors: Kia Sevda Haghi , Glynou Kyriaki , Nau Thomas , Thines Marco , Piepenbring Meike , Maciá-Vicente Jose G 
Published: November 2016

Abstract
Plants associate through their roots with fungal assemblages that impact their abundance and productivity. Non-mycorrhizal endophytes constitute an important component of such fungal diversity, but their implication in ecosystem processes is little known. Using a selection of 128 root-endophytic strains, we defined functional groups based on their traits and plant interactions with potential to predict community assembly and symbiotic association processes. In vitro tests of the strains’ interactions with Arabidopsis thaliana, Microthlaspi erraticum and Hordeum vulgare showed a net negative effect of fungal colonization on plant growth. The effects partly depended on the phylogenetic affiliation of strains, but also varied considerably depending on the plant-strain combination. The variation was partly explained by fungal traits shared by different lineages, like growth rates or melanization. The origin of strains also affected their symbioses, with endophytes isolated from Microthlaspi spp. populations being more detrimental to M. erraticum than strains from other sources. Our findings suggest that plant–endophyte associations are subject to local processes of selection, in which particular combinations of symbionts are favored across landscapes. We also show that different common endophytic taxa have differential sets of traits found to affect interactions, hinting to a functional complementarity that can explain their frequent co-existence in natural communities.
Powerful decomposition of complex traits in a diploid model
Authors: Hallin Johan , Märtens Kaspar , Young Alexander I. , Zackrisson Martin , Salinas Francisco , Parts Leopold , Warringer Jonas , Liti Gianni 
Published: November 2016

AbstractExplaining trait differences between individuals is a core and challenging aim of life sciences. Here, we introduce a powerful framework for complete decomposition of trait variation into its underlying genetic causes in diploid model organisms. We sequence and systematically pair the recombinant gametes of two intercrossed natural genomes into an array of diploid hybrids with fully assembled and phased genomes, termed Phased Outbred Lines (POLs). We demonstrate the capacity of this approach by partitioning fitness traits of 6,642 Saccharomyces cerevisiae POLs across many environments, achieving near complete trait heritability and precisely estimating additive (73%), dominance (10%), second (7%) and third (1.7%) order epistasis components. We map quantitative trait loci (QTLs) and find nonadditive QTLs to outnumber (3:1) additive loci, dominant contributions to heterosis to outnumber overdominant, and extensive pleiotropy. The POL framework offers the most complete decomposition of diploid traits to date and can be adapted to most model organisms.
Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease
Authors: Lim Youngbin , Bak So Young , Sung Keewon , Jeong Euihwan , Lee Seung Hwan , Kim Jin-Soo , Bae Sangsu , Kim Seong Keun 
Published: November 2016

AbstractThe type II CRISPR-associated protein Cas9 recognizes and cleaves target DNA with the help of two guide RNAs (gRNAs; tracrRNA and crRNA). However, the detailed mechanisms and kinetics of these gRNAs in the Cas9 nuclease activity are unclear. Here, we investigate the structural roles of gRNAs in the CRISPR-Cas9 system by single-molecule spectroscopy and reveal a new conformation of inactive Cas9 that is thermodynamically more preferable than active apo-Cas9. We find that tracrRNA prevents Cas9 from changing into the inactive form and leads to the Cas9:gRNA complex. For the Cas9:gRNA complex, we identify sub-conformations of the RNA–DNA heteroduplex during R-loop expansion. Our single-molecule study indicates that the kinetics of the sub-conformations is controlled by the complementarity between crRNA and target DNA. We conclude that both tracrRNA and crRNA regulate the conformations and kinetics of the Cas9 complex, which are crucial in the DNA cleavage activity of the CRISPR-Cas9 system.
Mesenchymal Stem Cells Combined with Hepatocyte Growth Factor Therapy for Attenuating Ischaemic Myocardial Fibrosis: Assessment using Multimodal Molecular Imaging
Authors: Chen Huizhu , Xia Rui , Li Zhenlin , Zhang Lizhi , Xia Chunchao , Ai Hua , Yang Zhigang , Guo Yingkun 
Published: November 2016

AbstractClinically, myocardial fibrosis is increasingly being recognized as a new therapeutic target for ischaemic heart diseases. The aim of this study was to investigate whether noninvasive multimodal molecular imaging could be used to dynamically assess whether the combination of bone marrow mesenchymal stem cells (BMSCs) and hepatocyte growth factor (HGF) therapy can synergistically attenuate myocardial fibrosis after myocardial infarction (MI). MI was induced in 28 rats by coronary ligation with subsequent injection of BMSCs/HGF, BMSCs, HGF, or saline into the border zone under echocardiography guidance. The therapeutic procedure and treatment effects were tracked and assessed using bioluminescence imaging (BLI) and cardiac magnetic resonance (MR) imaging. Four weeks after transplantation therapy, cardiac MR imaging demonstrated that BMSC/HGF-treated animals showed better ejection fractions (p < 0.001) and smaller scar sizes (p < 0.001) than those treated with BMSCs or HGF alone. Histopathological and immunohistochemical results showed less collagen deposition, increased microvessel densities and more regenerative cardiomyocytes in the BMSC/HGF-treated animals than in those receiving HGF or BMSCs alone (all p < 0.05). Multimodal molecular imaging allows a specific and timely strategy to be established for dynamically tracking treatment and noninvasively assessing the therapeutic effects. Under echocardiography guidance, intramyocardial injection of transfected HGF with BMSCs can enhance cell survival, improve cardiac function, stimulate angiogenesis and reduce myocardial fibrosis in a post-MI rat model.
Associations between adverse childhood experiences and clinical characteristics of eating disorders
Authors: Guillaume S. , Jaussent I. , Maimoun L. , Ryst A. , Seneque M. , Villain L. , Hamroun D. , Lefebvre P. , Renard E. , Courtet Ph. 
Published: November 2016

AbstractPatients with eating disorders (EDs) frequently report a history of childhood trauma (CT). We investigated whether certain subtypes of CT are associated with more severe features of EDs, independently of psychiatric comorbidity, and whether they act additively. One hundred and ninety-two patients with DSM-V-defined EDs were consecutively recruited. Five clinical characteristics were assessed: restraint, eating, shape and weight concerns on the EDE-Q, and daily functioning. CT was assessed by the childhood traumatism questionnaire. The clinical features were associated with at least one CT subtype (emotional, sexual or physical abuse, emotional neglect). Multivariate analyses adjusted for lifetime comorbid psychiatric disorders revealed that emotional abuse independently predicted higher eating, shape and weight concerns and lower daily functioning, whereas sexual and physical abuse independently predicted higher eating concern. A dose-effect relationship characterised the number of CT subtypes and the severity of the clinical features, suggesting a consistent and partly independent association between CT and more severe clinical and functional characteristics in EDs. Emotional abuse seems to have the most specific impact on ED symptoms. Last, not all CT subtypes have the same impact but they do act additively.