bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Gd12Co5.3Bi and Gd12Co5Bi, Crystalline Doppelgaenger with Low Thermal Conductivities.
Authors: Oliynyk Anton O. , Sparks Taylor D. , Gaultois Michael W. , Ghadbeigi Leila , Mar Arthur 
Published: August 2016

AbstractSingle crystals of Gd12Co5.3Bi are grown from elemental mixtures in the ratio 12:5:1 using small amounts of I2 in a small temperature gradient (evacuated silica tubes, 800→≈798 °C, 2 d).
ChemInform Abstract: Strongly Exchange Coupled Core|Shell Nanoparticles with High Magnetic Anisotropy: A Strategy Toward Rare‐Earth‐Free Permanent Magnets.
Authors: Lottini E. , Lopez‐Ortega A. , Bertoni G. , Turner S. , Meledina M. , Van Tendeloo G. , de Julian Fernandez C. , Sangregorio C. 
Published: August 2016

AbstractAntiferromagnetic(AFM)/ferrimagnetic(FiM) Co0.3Fe0.7O/Co0.6Fe2.4 O4 core‐shell nanoparticles (NPs) with a particle size of 6—18 nm are prepared by a one‐pot thermal decomposition process according to the literature involving mixed Fe and Co oleate complexes.
ChemInform Abstract: High Nuclearity Antimonato‐Polyoxovanadate Cluster {V15Sb6O42} as a Synthon for the Solvothermal in situ Generation of α‐ and β‐{V14Sb8O42} Isomers.
Authors: Wendt Michael , Naether Christian , Bensch Wolfgang 
Published: August 2016

AbstractThe high‐nuclearity cluster compound (I) is shown to be an excellent new synthon for the preparation of (II) containing the β‐V14Sb8O42 isomer and the new compound (V) containing the α‐V14Sb8O42 isomer.
ChemInform Abstract: Iridium‐Catalyzed Diastereoselective and Enantioselective Allylic Substitutions with Acyclic α‐Alkoxy Ketones.
Authors: Jiang Xingyu , Chen Wenyong , Hartwig John F. 
Published: August 2016

AbstractAllylic substitution reactions with acyclic α‐alkoxy ketones are catalyzed by a metallacyclic iridium complex to form products with contiguous stereogenic centers derived from the nucleophile and electrophile.
ChemInform Abstract: Electrophilic Activation of α,β‐Unsaturated Amides: Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated γ‐Butyrolactones.
Authors: Zhang Ming , Kumagai Naoya , Shibasaki Masakatsu 
Published: August 2016

Abstractα,β‐Unsaturated 7‐azaindoline amides act as reactive electrophiles in diastereo‐ and enantioselective vinylogous conjugate additions of γ‐butyrolactones in the presence of a cooperative catalyst comprising a soft Lewis acid and a Broensted base.
ChemInform Abstract: Synthesis of Functionalized 2‐Trifluoromethylquinolines and Their Heteroaromatic Analogues.
Authors: Khutoryanskiy Viktor V. , Biitseva Angelina V. , Mykhailiuk Pavel K. 
Published: August 2016

Abstractby cyclization of electron‐rich anilines with heterocyclic CF3‐containing amines
ChemInform Abstract: Primary Polyfluoroalkanethioamides as Mild Thioacylating Reagents for Alkyl Amines and α‐Amino Acid Esters.
Authors: Pikun Nadiia V. , Mykhaylychenko Sergiy S. , Kulik Irine B. , Shermolovich Yuriy G. 
Published: August 2016

AbstractNew polyfluoroalkanethioyl derivatives are prepared by transamidation of primary amides of polyfluoroalkanethiocarboxylic acids with alkyl amines under mild reaction conditions.
ChemInform Abstract: A General Method for Aminoquinoline‐Directed, Copper‐Catalyzed sp2 C—H Bond Amination.
Authors: Roane James , Daugulis Olafs 
Published: August 2016

AbstractPrimary, secondary, and aromatic amines, heterocycles as well as electron‐deficient aromatic and heteroaromatic are employed as amine coupling partners using Cu(OAc)2 or CuCO3·Cu(OH)2 as catalysts and oxygen from the air as the terminal oxidant.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Coupling of (Hetero)aryl Chlorides with Aryllithium Compounds.
Authors: Tao Jian‐Long , Wang Zhong‐Xia 
Published: August 2016

AbstractA nickel pincer complex catalyzes cross‐coupling reactions of aryl or heteroaryl chlorides with aryllithiums to give biaryls under mild reaction conditions.
ChemInform Abstract: Nickel‐Catalyzed Carboxylation of Benzylic C—N Bonds with CO2.
Authors: Moragas Toni , Gaydou Morgane , Martin Ruben 
Published: August 2016

AbstractAn user‐friendly Ni‐catalyzed reductive carboxylation of benzylic C—N bonds with CO2 is described.
ChemInform Abstract: Microwave Assisted Multi‐Component Synthesis of Novel Bis(1,4‐dihydropyridines) Based Arenes or Heteroarenes.
Authors: Elwahy Ahmed H. M. , Abdelhamid Ismail A. , Sanad Sherif M. H. , Kassab Refaie M. 
Published: August 2016

AbstractThe yields in the reaction of arene‐coupled dialdehydes with aminobutenenitrile are significantly higher by using microwave heating compared to conventional heating.
ChemInform Abstract: Catalytic Enantioselective Synthesis of Halocyclopropanes.
Authors: Pons Amandine , Ivashkin Pavel , Poisson Thomas , Charette Andre B. , Pannecoucke Xavier , Jubault Philippe 
Published: August 2016

AbstractCyclopropanation of 2‐haloalkenes with α‐cyano‐diazoacetates in the presence of a chiral Rh‐catalyst provides a general synthesis of highly functionalized cyclopropanes such as (III) and (V).
ChemInform Abstract: Pd/C‐Catalyzed Carbonylative Esterification of Aryl Halides with Alcohols by Using Oxiranes as CO Sources.
Authors: Min Byul‐Hana , Kim Dong‐Su , Park Hyo‐Soon , Jun Chul‐Ho 
Published: August 2016

AbstractA new Pd(0)‐catalyzed carbonylative esterification of aryl bromides is developed using styrene oxide as CO‐source.
ChemInform Abstract: A Highly Efficient Heterogeneous Copper‐Catalyzed Chan—Lam Coupling Reaction of Sulfonyl Azides with Arylboronic Acids Leading to N‐Arylsulfonamides.
Authors: You Chongren , Yao Fang , Yan Tao , Cai Mingzhong 
Published: August 2016

AbstractThe use of the novel silica supported catalyst (CUP) allows the synthesis of a wide range of N‐arylsulfonylamides at room temperature under air without the need for any base or additive.
ChemInform Abstract: Highly Stereoselective [3 + 2] Cycloadditions of Chiral Palladium‐Containing N1‐1,3‐Dipoles: A Divergent Approach to Enantioenriched Spirooxindoles.
Authors: Li Tian‐Ren , Cheng Bei‐Yi , Fan Si‐Qi , Wang Ya‐Ni , Lu Liang‐Qiu , Xiao Wen‐Jing 
Published: August 2016

AbstractA catalytic asymmetric cycloaddition of 1,3‐dipoles, generated in situ by ring‐opening of aziridines, with 3‐methylene‐2‐oxindoles is developed furnishing spirooxindoles in high yields and excellent stereoselectivities.
ChemInform Abstract: Unusual Formal [1 + 4] Annulation Through Tandem P(NMe2)3‐Mediated Cyclopropanation/Base‐Catalyzed Cyclopropane Rearrangement: Facile Syntheses of Cyclopentenimines and Cyclopentenones.
Authors: Zhou Rong , Zhang Kai , Han Ling , Chen Yusong , Li Ruifeng , He Zhengjie 
Published: August 2016

AbstractA formal [1+4] annulation of α‐dicarbonyl compounds with 1,1‐dicyano‐1,3‐dienes is realized, leading to facile syntheses of cyclopentenimines and cyclopentenones in a unique manner.
ChemInform Abstract: Silver‐Catalyzed 7‐exo‐dig Cyclization of Silylenolether‐ynesulfonamides.
Authors: Heinrich Clement F. , Fabre Indira , Miesch Laurence 
Published: August 2016

AbstractCyclization of silylenolether‐ynesulfonamides proceeds at ambient temperature under mild reaction conditions under silver catalysis.
ChemInform Abstract: Studies on the Enantioselective Kinugasa Reaction: Efficient Synthesis of β‐Lactams Catalyzed by N‐PINAP/CuX Complexes.
Authors: Wolosewicz Karol , Michalak Michal , Adamek Jakub , Furman Bartlomiej 
Published: August 2016

AbstractNoteworthy, the Cu salt is shown to have big influence on the enantioselectivity of the Kinugasa reaction in the presence of N‐PINAP ligands.
ChemInform Abstract: Direct Oxidative Lactonization of Alkenoic Acids Mediated Solely by NaIO4: Beyond a Simple Oxidant.
Authors: Kang Yan‐Biao , Chen Xian‐Min , Yao Chuan‐Zhi , Ning Xiao‐Shan 
Published: August 2016

AbstractNaIO4 works not only as an oxidant.
ChemInform Abstract: Positional Selectivity in C—H Functionalizations of 2‐Benzylfurans with Bimetallic Catalysts.
Authors: Zhang Jiadi , Sha Sheng‐Chun , Bellomo Ana , Trongsiriwat Nisalak , Gao Feng , Tomson Neil C. , Walsh Patrick J. 
Published: August 2016

AbstractBimetallic catalysts, generated in situ from Pd(O—Ac)2, the ligand and a base, exert a high degree of control in site‐selective arylation reactions of both sp2 and sp3 C—H bonds in 2‐benzylfurans.
ChemInform Abstract: Desilylation‐Activated Propargylic Transformation: Enantioselective Copper‐Catalyzed [3 + 2] Cycloaddition of Propargylic Esters with β‐Naphthol or Phenol Derivatives.
Authors: Shao Long , Wang Ya‐Hui , Zhang De‐Yang , Xu Jie , Hu Xiang‐Ping 
Published: August 2016

AbstractA copper‐catalyzed asymmetric [3+2] cycloaddition of 3‐trimethylsilylpropargylic esters with either β‐naphthols or electron‐rich phenols is realized and proceeds by a desilylation‐activated process.
ChemInform Abstract: Three‐Component 2‐Aryl Substituted Benzothiophene Formation under Transition‐Metal Free Conditions.
Authors: Jiang Pengcheng , Che Xingzong , Liao Yunfeng , Huang Huawen , Deng Guo‐Jun 
Published: August 2016

AbstractIn this novel approach to 2‐arylbenzothiophenes, esters and 2‐halobenzaldehydes are applied as reactants together with elemental sulfur.
ChemInform Abstract: Rhodium‐Catalyzed Enantioselective Arylation of N‐Substituted α,β‐Unsaturated γ‐Lactams: Preparation of Chiral 4‐Aryl‐2‐pyrrolidones.
Authors: Fang Jo‐Hsuan , Chang Chiung‐An , Gopula Balraj , Kuo Ting‐Shen , Wu Ping‐Yu , Henschke Julian P. , Wu Hsyueh‐Liang 
Published: August 2016

AbstractA highly stereoselective conjugate addition of arylboronic acids and N‐substituted α,β‐unsaturated γ‐lactams provides the chiral title pyrrolidones.
ChemInform Abstract: Efficient Synthesis of Indole Derivatives via Tandem Cyclization Catalyzed by Magnetically Recoverable Palladium/Magnetite (Pd‐Fe3O4) Nanocrystals.
Authors: Kwon Jungmin , Chung Jooyoung , Byun Sangmoon , Kim B. Moon 
Published: August 2016

AbstractA Sonogashira coupling reaction of 2‐haloanilines and alkynes followed by tandem cyclization affords the title indoles.
ChemInform Abstract: Rh(III)‐Catalyzed Chemoselective C—H Functionalizations of Tertiary Aniline N‐Oxides with Alkynes.
Authors: Huang Xiaolei , Liang Wenbo , Shi Yang , You Jingsong 
Published: August 2016

AbstractIn the case of aniline oxides (XI) with strong electron‐withdrawing groups and cyclic aniline N‐oxides (XIII) diphenylacetylene adds regioselectively in the ortho‐position accompanied by an O‐atom transfer.
ChemInform Abstract: Cu/Fe Catalyzed Intermolecular Oxidative Amination of Benzylic C—H Bonds.
Authors: Liu Cong , Zhang Qi , Li Hongbo , Guo Shuangxi , Xiao Bin , Deng Wei , Liu Lei , He Wei 
Published: August 2016

AbstractAn oxidative cyclization of o‐alkyl substituted benzoic acids through a Ritter‐type reaction with acetonitrile is described to provide N‐acetyl substituted lactams in moderate to good yields.
ChemInform Abstract: Catalyst‐Free Three‐Component Tandem CDC Cyclization: Convenient Access to Isoindolinones from Aromatic Acid, Amides, and DMSO by a Pummerer‐Type Rearrangement.
Authors: Wang Peng‐Min , Pu Fan , Liu Ke‐Yan , Li Chao‐Jun , Liu Zhong‐Wen , Shi Xian‐Ying , Fan Juan , Yang Ming‐Yu , Wei Jun‐Fa 
Published: August 2016

AbstractA catalyst free three‐component reaction of 3,4,5‐trimethoxybenzoic acid with sulfonamides or carboxylic amides and DMSO as methylene source proceeds through a Pummerer‐type rearrangement to provide a convenient access to N‐substituted isoindolinones.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Multicomponent Synthesis of Functionalized Benzimidazothiazoles
Authors: Veltri Lucia , Grasso Giuseppe , Rizzi Rosanna , Mancuso Raffaella , Gabriele Bartolo 
Published: August 2016

Abstractby domino oxidative aminocarbonylation/heterocyclization of propynylthiobenzimidazolium bromides with various amines and CO
ChemInform Abstract: Copper‐II Mediated Tandem Reaction Between Aromatic Ketones and 2‐Aminobenzenethiol for the Synthesis of 2‐Aroylbenzothiazoles.
Authors: Mali Jaishree K. , Mali Devidas A. , Telvekar Vikas N. 
Published: August 2016

AbstractA simple, mild, and efficient aerobic, Cu(II)‐mediated tandem protocol for the synthesis of 2‐aroylbenzothiazoles is developed.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition of Carbodiimides and Nitrilimines: Synthesis and Mechanistic Study of 5‐Amino‐1,2,4‐triazoles.
Authors: Yen Wan‐Ping , Kung Fung‐Chun , Wong Fung Fuh 
Published: August 2016

Abstract1,3‐Dipolar cycloaddition of nitrilimines, generated from hydrazonoyl chlorides with carbodiimides (II) provides a novel synthesis of 5‐amino‐1,2,4‐triazoles.
ChemInform Abstract: Direct Construction of Chiral Quaternary Dihydropyranones Through Highly Enantioselective Organocatalytic hetero‐Diels—Alder Reactions of Olefinic Azlactones.
Authors: Gao Tai‐Ping , Liu Dan , Lin Jun‐Bing , Hu Xiu‐Qin , Wang Zhu‐Yin , Xu Peng‐Fei 
Published: August 2016

AbstractFor the first time, an enantioselective hetero‐Diels—Alder reaction of an in situ generated diene with β,γ‐unsaturated α‐keto esters or α‐keto esters is reported.
ChemInform Abstract: Antibacterial Structure—Activity Relationship Studies of Several Tricyclic Sulfur‐Containing Flavonoids.
Authors: Bahrin Lucian G , Hopf Henning , Jones Peter G , Sarbu Laura G , Babii Cornelia , Mihai Alina C , Stefan Marius , Birsa Lucian M 
Published: August 2016

AbstractThe title compounds (IV) are prepared by cyclocondensation of 3‐dithiocarbamic flavones (III) and (VI).
ChemInform Abstract: An Efficient One‐Pot Regioselective Approach Towards the Synthesis of Thiopyrano[2,3‐d]thiazole‐2‐thiones Catalyzed by Basic Ionic Liquid under Microwave Irradiation.
Authors: Siddiqui I. R. , Srivastava Arjita , Shamim Shayna , Srivastava Anjali , Shireen Anjali , Waseem Malik A. 
Published: August 2016

AbstractA green method for preparation of the title thiopyran derivatives by cyclocondensation of (thioxo)thiazolidinone, benzaldehydes, and β‐oxodithioesters using ionic liquid as catalyst and solvent is developed.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Four‐Component Synthesis of Thiochromenones: The Advantages of a Reagent Capsule.
Authors: Shen Chaoren , Spannenberg Anke , Wu Xiao‐Feng 
Published: August 2016

AbstractThe use of paraffin wax‐encapsulated Na2S·9H2O provides a straightforward access to synthetically valuable thiochromenone derivatives by a palladium‐catalyzed carbonylative four‐component reaction.
ChemInform Abstract: Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates.
Authors: Zhang Enxuan , Tang Jiaze , Li Suhua , Wu Peng , Moses John E. , Sharpless K. Barry 
Published: August 2016

AbstractA selection of heteroaryl fluorosulfates is synthesized using commercial SO2F2 gas.
ChemInform Abstract: Cooperative Lewis Acid/Cp*CoIII Catalyzed C—H Bond Activation for the Synthesis of Isoquinolin‐3‐ones.
Authors: Kim Ju Hyun , Gressies Steffen , Glorius Frank 
Published: August 2016

AbstractBased on a Co(III)‐catalyzed C—H activation of imines such as (I), the reaction with diazo compounds offers a convenient method for the synthesis of isoquinolin‐3‐ones.
ChemInform Abstract: A Catalyst‐Free, One‐Pot Multicomponent Synthesis of Spiro‐Benzimidazoquinazolinones via a Knoevenagel—Michael‐Imine Pathway: A Microwave Assisted Approach.
Authors: Maloo Preeti , Roy Tapta Kanchan , Sawant Devesh M. , Pardasani Ram T. , Salunkhe Manikrao M. 
Published: August 2016

AbstractIn this novel three‐component approach, the title compounds are simply prepared by short microwave‐heating.
ChemInform Abstract: ortho‐Functionalized Aryltetrazines by Direct Palladium‐Catalyzed C—H Halogenation: Application to Fast Electrophilic Fluorination Reactions.
Authors: Testa Christelle , Gigot Elodie , Genc Semra , Decreau Richard , Roger Julien , Hierso Jean‐Cyrille 
Published: August 2016

AbstractReaction conditions are developed for ortho‐selective Pd‐catalyzed C—H functionalization of biphenyl‐1,2,4,5‐tetrazine.
ChemInform Abstract: Enantioselective Synthesis of Silacyclopentanes.
Authors: Igawa Kazunobu , Yoshihiro Daisuke , Abe Yusuke , Tomooka Katsuhiko 
Published: August 2016

AbstractFunctionalized silacyclopentanes are synthesized by enantioselective β‐elimination of silacyclopentene oxides and subsequent stereospecific transformations using a newly developed chiral lithium amide.
ChemInform Abstract: Rhodium‐Catalyzed Synthesis of Chiral Spiro‐9‐silabifluorenes by Dehydrogenative Silylation: Mechanistic Insights into the Construction of Tetraorganosilicon Stereocenters.
Authors: Murai Masahito , Takeuchi Yutaro , Yamauchi Kanae , Kuninobu Yoichiro , Takai Kazuhiko 
Published: August 2016

AbstractMechanistic insight into the construction of quaternary silicon chiral centers by rhodium‐catalyzed synthesis of spiro‐9‐silabifluorenes through dehydrogenative silylation is reported.
ChemInform Abstract: Nickel‐Catalyzed Phosphorylation of Phenol Derivatives via C—O/P—H Cross‐Coupling.
Authors: Yang Jia , Xiao Jing , Chen Tieqiao , Han Li‐Biao 
Published: August 2016

AbstractBoth H‐phosphonates and secondary phosphine oxides are suitable substrates for this Ni‐catalyzed phosphorylation of phenol derivatives.
ChemInform Abstract: Sporulaminals A and B: A Pair of Unusual Epimeric Spiroaminal Derivatives from a Marine‐Derived Fungus Paraconiothyrium sporulosum YK‐03.
Authors: Zhang Li‐Hua , Feng Bao‐Min , Chen Gang , Li Sheng‐Ge , Sun Yi , Wu Hong‐Hua , Bai Jiao , Hua Hui‐Ming , Wang Hai‐Feng , Pei Yue‐Hu 
Published: August 2016

AbstractC‐4 epimeric sporulaminals A (I) and B (II) are the first representatives of spiroaminals with a 6/4/5/5 tetracyclic ring system derived from bergamotane sesquiterpenoid.
ChemInform Abstract: Microwave‐Assisted Rapid Enzymatic Synthesis of Nucleic Acids.
Authors: Hari Das Rakha , Ahirwar Rajesh , Kumar Saroj , Nahar Pradip 
Published: August 2016

AbstractThe microwave‐induced enhancement of reactions catalyzed by Escherichia coli DNA polymerase I and avian myeloblastosis virus‐reverse transcriptase is reported.
ChemInform Abstract: Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates.
Authors: Cantley Alexandra M. , Woznica Arielle , Beemelmanns Christine , King Nicole , Clardy Jon 
Published: August 2016

AbstractAn atypical sulfonolipid (I) with rare syn‐diol configuration that inhibits the conversion from unicellular to a multicellular morphology in choanoflagellates is isolated.
ChemInform Abstract: A New Isoflavanol from the Fruits of Kotschya strigosa (Fabaceae).
Authors: Awouafack Maurice D. , Tchuenguem Roland T. , Ito Takuya , Dzoyem Jean P. , Tane Pierre , Morita Hiroyuki 
Published: August 2016

AbstractThe isolation of the new isoflavanol named kotstrigoisoflavanol (I) together with three known compounds, is achieved by phytochemical investigation of the fruits of Kotschya strigosa (Fabaceae).
ChemInform Abstract: Antiinflammatory Prenylated Flavonoids from Helminthostachys zeylanica.
Authors: Su Li‐Hua , Li Yan‐Ping , Li Hong‐Mei , Dai Wei‐Feng , Liu Dan , Cao Lang , Li Rong‐Tao 
Published: August 2016

AbstractTwo new prenylated flavonoids, neougonins A (I) and B (II), are isolated from the whole plant of Helminthostachys zeylanica along with nine known compounds.
ChemInform Abstract: Enantioselective Construction of Chiral 2,3‐cis‐Dimethyldihydrobenzofuran with an All‐Carbon Quaternary Center: An Efficient Approach to (+)/(‐)‐PI‐220 and (+)‐3‐epi‐Furaquinocin C.
Authors: Pu Liu‐Yang , Chen Ji‐Qiang , Li Mao‐Lin , Li Yao , Xie Jian‐Hua , Zhou Qi‐Lin 
Published: August 2016

AbstractTotal syntheses of the title compounds establishes the absolute configuration of naturally occurring PI‐220 as (2S,3R).
ChemInform Abstract: Water at Interfaces
Authors: Bjoerneholm Olle , Hansen Martin H. , Hodgson Andrew , Liu Li‐Min , Limmer David T. , Michaelides Angelos , Pedevilla Philipp , Rossmeisl Jan , Shen Huaze , Tocci Gabriele , et al.  
Published: August 2016

AbstractReview: 306 refs.
ChemInform Abstract: Paving the Way for Lignin Valorisation: Recent Advances in Bioengineering, Biorefining and Catalysis
Authors: Rinaldi Roberto , Jastrzebski Robin , Clough Matthew T. , Ralph John , Kennema Marco , Bruijnincx Pieter C. A. , Weckhuysen Bert M. 
Published: August 2016

AbstractReview: 427 refs.
Single‐Molecule Fluorescence Detection of a Synthetic Heparan Sulfate Disaccharide
Authors: Dalton Charlotte E. , Quinn Steven D. , Rafferty Aidan , Morten Michael J. , Gardiner John M. , Magennis Steven W. 
Published: August 2016

AbstractThe first single‐molecule fluorescence detection of a structurally‐defined synthetic carbohydrate is reported: a heparan sulfate (HS) disaccharide fragment labeled with Alexa488. Single molecules have been measured whilst freely diffusing in solution and controlled encapsulation in surface‐tethered lipid vesicles has allowed extended observations of carbohydrate molecules down to the single‐molecule level. The diverse and dynamic nature of HS–protein interactions means that new tools to investigate pure HS fragments at the molecular level would significantly enhance our understanding of HS. This work is a proof‐of‐principle demonstration of the feasibility of single‐molecule studies of synthetic carbohydrates which offers a new approach to the study of pure glycosaminoglycan (GAG) fragments.
Berberine Hydrochloride Protects C2C12 Myoblast Cells Against Oxidative Stress‐Induced Damage via Induction of Nrf‐2‐Mediated HO‐1 Expression
Authors: Choi Yung Hyun 
Published: August 2016

ABSTRACT

Preclinical Research

The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2O2)‐induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO‐1 pathway. BBH preconditioning attenuated H2O2‐induced growth inhibition and DNA damage as well as apoptosis in C2C12 cells via suppression of the accumulation of intracellular reactive oxygen species (ROS). Treatment with BBHride alone effectively upregulated the expression of nuclear factor‐erythroid 2‐related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1) and elevated HO‐1 activity. However, the protective effects of BBH against H2O2‐induced ROS generation and cell growth reduction were abolished by an HO‐1 inhibitor. Moreover, BBH‐mediated induction and activation of HO‐1 were reduced by genetic silencing of Nrf2 using small interfering RNA (siRNA). In addition, the effects of BBH against H2O2‐induced ROS accumulation and growth inhibition were abrogated in C2C12 cells transfected with Nrf2 siRNA. Therefore, the present study demonstrated that BBH could protect C2C12 cells against oxidative stress‐induced injury and this effect involved activation of the Nrf2/HO‐1 pathway. Drug Dev Res, 2016. © 2016 Wiley Periodicals, Inc.