bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of sedation with midazolam–ketamine versus propofol–fentanyl during endoscopy in children: a randomized trial
Authors: Akbulut Ulas E. , Saylan Sedat , Sengu Bilal , Akcali Gulgun E. , Erturk Engin , Cakir Murat 
Published: September 2016

Purpose
We aimed to compare the efficacy and safety of midazolam plus ketamine versus fentanyl plus propofol combination administered to children undergoing upper gastrointestinal endoscopy (UGE) and to determine the most appropriate sedation protocol.

Materials and methods
This prospective, randomized, single-blind study included patients between the ages of 4 and 17 years who underwent UGE for diagnostic purposes. Patients were divided randomly into groups A (midazolam–ketamine combination, n=119) and B (fentanyl plus propofol combination, n=119). The effectiveness of the sedation and complications during the procedure and recovery period were recorded.

Results
The processes started without an additional dose of the drug for 118 patients (99.1%) in group A and for 101 patients (84.8%) in group B (P=0.001). The average dose of ketamine administered to the patients in group A was 1.03±0.15 mg/kg and the average dose of propofol administered to the patients in group B was 1.46±0.55 mg/kg. None of the patients stopped the endoscopic procedure in group A, but one patient (0.8%) had to discontinue the endoscopic procedure in group B. 27 patients in group A (22.7%) and 41 patients (34.5%) in group B developed complications during the procedure (P=0.044). The rate of complications during the recovery of group A (110 patients, 92.4%) was significantly higher than that in group B (48 patients, 40.3%) (P=0.001).

Conclusion
In children, UGE procedures can be quite comfortable when using the midazolam–ketamine combination. However, adverse effects related to ketamine were observed during recovery.
Multiplex Competition, Collaboration, and Funding Networks Among Health and Social Organizations
Authors: Fujimoto Kayo , Wang Peng , Kuhns Lisa M. , Ross Michael W. , Williams Mark L. , Garofalo Robert , Klovdahl Alden S. , Laumann Edward O. , Schneider John A. 
Published: September 2016

Background:
Young men who have sex with men (YMSM) have the highest rates of human immunodeficiency virus (HIV) infection in the United States. Decades into the HIV epidemic, the relationships that YMSM-serving health and social organizations have with one another has not been studied in depth.

Objectives:
The aim of this study was to examine the competition, collaboration, and funding source structures of multiplex organization networks and the mechanisms that promote fruitful relationships among these organizations.

Research Design:
The study data collection method was a survey of health and social organizations from 2013–2014 in 2 cities, Chicago, IL and Houston, TX.

Subjects:
Study participants were representatives from 138 health and social organizations.

Measures:
Responses to survey questions were used to reconstruct competition, collaboration, and combined competition-collaboration networks.

Results:
While taking into consideration the collaborative relationships among organizations, we provide statistical evidence that organizations of similar type, similar social media use patterns, comparable patterns of funding, and similar network contexts tended to compete with one another. This competition was less likely to be accompanied by any sort of collaboration if the organizations shared common funding sources.

Conclusions:
Competition that excludes potential collaboration may be detrimental to mobilizing the collective efforts that serve local YMSM communities. System-level interventions may provide promising approaches to scaling-up HIV prevention and treatment efforts so as to encourage organizations to form partnerships with otherwise competing providers.
New oral agents for treating dyslipidemia
Authors: Gryn Steven E. , Hegele Robert A. 
Published: September 2016

Purpose of review
We provide an overview of orally administered lipid-lowering therapies under development.

Recent findings
Recent data support statins for intermediate risk primary prevention, and ezetimibe for high-risk secondary prevention. Novel agents in development include bempedoic acid and gemcabene, and work continues on one remaining cholesteryl ester transfer protein inhibitor, anacetrapib, to determine whether this class can reduce cardiovascular risk. Selective peroxisome proliferator-activated receptor modulators such as K-877 are under study to determine whether they have an advantage over older fibrates. Diacylglycerol transferase inhibitors such as pradigastat appear to have potent triglyceride-lowering effects, even for patients with familial chylomicronemia syndrome. Finally, novel ω-3 preparations are available with significant triglyceride lowering, although their role in therapy remains unclear.

Summary
Statins will remain the backbone of lipid-lowering therapy, although several novel oral agents are promising. The common theme across drugs in development is the demonstration of good lipid-lowering effect, although lacking cardiovascular outcomes data, which will likely be necessary before any of them, can be recommended or approved for widespread use.
Important considerations in adolescent health maintenance: long-acting reversible contraception, human papillomavirus vaccination, and heavy menstrual bleeding
Authors: Brodie Nicola , Silberholz Elizabeth A. , Spector Nancy D. , Pattishall Amy E. 
Published: September 2016

Purpose of review
The present article addresses recent research related to three key facets of adolescent preventive care and health maintenance: long-acting reversible contraception, human papillomavirus vaccination, and heavy menstrual bleeding.

Recent findings
Recent studies suggest that long-acting reversible contraception use results in significantly lower rates of unintended pregnancies, and is well tolerated by nulliparous adolescent females. Additionally, a strong recommendation from a pediatric primary care provider is extremely effective in ensuring human papillomavirus vaccination prior to sexual debut. Finally, heavy menstrual bleeding is often under-recognized in adolescents, and evaluation and treatment of these patients are variable.

Summary
Based on the recent literature findings, the pediatric primary care provider should be encouraged to, first, recommend long-acting reversible contraception for prevention of unintended pregnancy in adolescent patients; second, strongly endorse vaccination to protect against human papillomavirus in all patients prior to sexual debut; and, third, screen adolescent females for signs and symptoms of heavy menstrual bleeding.
Can Anal Sphincter Defects Be Identified by Palpation?
Authors: Shek Ka Lai , Atan Ixora Kamisan , Dietz Hans Peter 
Published: September 2016

Objectives
The aim of this study was to correlate clinical findings of anal sphincter defects and function with a sonographic diagnosis of significant sphincter defects.

Methods
This is an observational cross-sectional study on women seen 6 to 10 weeks after primary repair of obstetric anal sphincter injuries (OASIs). All patients underwent a standardized interview including the St Mark incontinence score, a digital rectal examination, and 3-/4-dimensional transperineal ultrasound imaging.

Results
Two hundred forty-five patients were seen after primary repair of OASIs. Mean age was 29 (17–43) years. They were assessed at a median of 58 (15–278) days postpartum. One hundred fifty-seven (64%) delivered normal vaginally, 72 (29%) delivered by vacuum, and 16 (7%) delivered by forceps. A comparison of external anal sphincter (EAS) and internal anal sphincter ultrasound volume data and palpation was possible in 220 and 212 cases, respectively. Sphincter defects at rest and on contraction were both detected clinically in 17 patients. Significant abnormalities of the EAS were diagnosed on tomographic ultrasound imaging in 99 cases (45%), and significant abnormalities of the internal anal sphincter were diagnosed in 113 cases (53%). Agreement between digital and sonographic findings of sphincter defect was poor (k = 0.03–0.08). Women with significant EAS defects on ultrasound were found to have a lower resistance to digital insertion (P = 0.018) and maximum anal squeeze (P = 0.009) on a 6-point scale. The difference was however small.

Conclusions
Digital rectal examination does not seem to be sufficiently sensitive to diagnose residual sphincter defects after primary repair of OASIs. Imaging is required for the evaluation of sphincter anatomy after repair.
The confused oncologic patient: a rational clinical approach
Authors: Nolan Craig , DeAngelis Lisa M. 
Published: September 2016

Purpose of review
The purpose of this review is to provide a practical clinical approach to confusion in the patient with cancer. Confusion in the cancer population has a broader differential diagnosis than in the general medical population. The clinician must consider the usual differential diagnoses as well as causes unique to the cancer patient including direct complications from the cancer and indirect complications related to cancer treatment.

Recent findings
In the recent age of precision medicine, the oncologist now utilizes the genomic profile of both the patient and the tumor to provide advanced biologic therapies including targeted anticancer drugs, antiangiogenic agents, and immunotherapy. Such advances carry with them an emerging pattern of neurotoxicity which, although less well described in the literature, is now an important consideration to the clinical approach to confusion in cancer patients.

Summary
Confusion is the most common neurologic complication in cancer and is associated with significant morbidity, mortality, and prolonged hospital stays resulting in increased healthcare costs. Early recognition and treatment of delirium is essential to improve clinical outcomes.
Control without controllers: Towards a distributed neuroscience of executive control
Authors: Eisenreich Benjamin R. , Akaishi Rei , Hayden Benjamin Y. 
Published: September 2016

AbstractExecutive control refers to the regulation of cognition and behavior by mental processes and is a hallmark of higher cognition. Most approaches to understanding its mechanisms begin with the assumption that our brains have anatomically segregated and functionally specialized control modules. The modular approach is intuitive: control is conceptually distinct from basic mental processing, so an organization that reifies that distinction makes sense. An alternative approach sees executive control as self-organizing principles of a distributed organization. In distributed systems, control and controlled processes are co-localized within large numbers of dispersed computational agents. Control then is often an emergent consequence of simple rules governing the interaction between agents. Because these systems are unfamiliar and unintuitive, here we review several well-understood examples of distributed control systems, group living insects and social animals, and emphasize their parallels with neural systems. We then re-examine the cognitive neuroscience literature on executive control for evidence that its neural control systems may be distributed.
SMCH – the innovative pediatric care hospital from India
Authors: Mohanty Ragini N. , Shah Richa 
Published: September 2016

Subject area
The subject area is entrepreneurship.

Study level/applicability
Graduate and executive education level in leadership, entrepreneurship and strategic management are used to discuss leadership, entrepreneurship and strategy in health services.

Case overview
This case talks about the passionate journey of a pediatrician practicing in the Mumbai city of India, who as an individual private practitioner is contributing to the fulfilment of the global health agenda and the fourth Millennium Development Goal (MDG) – “reduce child mortality”. His vision is to make quality and affordable expert pediatric care accessible to all the individuals, right from pre-birth to adulthood. Surya Mother and Child Care Hospital (SMCH) is being strengthened as a nation-wide network of mother and child hospital offering patient/consumer-centric integrated collaborative quality care, and it needs to be seen how this model can be made sustainable as it enlarges in scale for the future.

Expected learning outcomes
The case is structured to achieve the following learning outcomes: to understand about effectuation as a logic for entrepreneurial success through the lens of Dr Avasthi and his venture SMCH; To understand and apply Porter’s Principles of value transformation that essentially focus on outcome-driven cost-efficient work practices in a collaborative integrative fashion, where transformation must come from within (some practices suggested can be applied to the Indian Healthcare Services Delivery systems); to critically analyze the overall strategic position of SMCH as an organization and its competitive environment; to discuss the factors influencing health-care delivery capacity build up, given the MDGs 2015, Every Newborn Action Plan and Indian Newborn Action Plan framework, as applicable to India; and to discuss and analyze mechanisms for future sustainable service delivery options for SMCH. Although each of these principles is important, possibly, the instructor could emphasize and encourage more discussions on potential models of shared partnerships that can help quality health-care services reach the unreached and the incorporation of technology in achieving this. The learning process can also facilitate discussions about leadership qualities in the creation of health-care entrepreneurs, for the “Change That They Would Want To See”.

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS:3 Entrepreneurship.
Entrepreneurial motives and their antecedents of men and women in North Africa and the Middle East
Authors: Bastian Bettina Lynda , Zali Mohammad Reza 
Published: September 2016

PurposeThis study aims to investigate how educational attainment and entrepreneurial competencies affect entrepreneurial motives of women (vs men) in the Middle East and North Africa (MENA). This study shows that education has a more positive effect on women’s entrepreneurial motives compared with men. On the other hand, there is a greater positive effect of competencies on men’s motives. Moreover, the moderating effects of culture are compared. The results of the multiple regression analysis show that, within the MENA region, the cultural value of self-expressionism engenders increased opportunity-motivated entrepreneurship by men. Yet, it has no significant effect on women’s entrepreneurial motives.Design/methodology/approachThis study analyses survey data using multiple regression analysis, relationship between independent variables, educational attainment and entrepreneurial competencies, as well as culture, and the dependent variable, entrepreneurial motivation. The present study focuses on data records concerning 13 MENA countries, notably, Algeria, Egypt, Iran, Jordan, Lebanon, Morocco, Pakistan, Saudi Arabia, Syria, Tunisia, Turkey, United Arab Emirates and Yemen. The sample includes early-stage and established female entrepreneurs, a total of 1,551 respondents, for all countries for the entire period.FindingsEntrepreneurs with higher levels of education and competencies are more likely to exploit market opportunities. However, effects from educational attainments and competencies are significantly stronger for men. Moreover, the increasing introduction of liberal or post-modern values in MENA societies has significant effects on men but no effect on women, suggesting that men tend to benefit much more than women in the Arab world with regards to their entrepreneurial behaviour.Originality/valueThe study is one of the few attempts to clarify the relationship between individual factors, here represented by education and competencies, and environmental factors, here represented by culture (post-modern values) and entrepreneurial motivation. Moreover, it addresses the MENA region, which is a politically and economically important and challenging environment, and which, to date, has received relatively little attention in entrepreneurship research.
Psychological and structural bias in civil jury awards
Authors: Girvan Erik , Marek Heather J. 
Published: September 2016

Purpose
The purpose of this paper is twofold. First, it proposes a basic organizing framework for when a plaintiff’s race, ethnicity, or sex may impact civil jury awards. The framework takes into account psychological and structural sources of bias and the ways in which they may interact when jurors have more or less discretion. Second, the paper employs a methodological innovation to overcome one of the primary barriers to empirical field research on bias in civil legal decisions: the absence of plaintiff demographic information.

Design/methodology/approach
The data set is comprised of jury verdicts in tort cases combined with information from the US Census Bureau regarding race and ethnicity. Statistical tests measure the relationships between race, ethnicity, sex, and awards for economic damages and pain and suffering.

Findings
Overall, the results were consistent with the psycho-structural framework. Where jurors had discretion (i.e. pain and suffering damages), they awarded less to black plaintiffs than to white plaintiffs, indicating potential psychological bias. Where jurors had little discretion (i.e. lost income) they awarded less to female plaintiffs and more to Asian plaintiffs than to male and white plaintiffs, respectively, a potential reflection of structural income disparities. Thus, the framework and method have promise for exploring relationships between structural and psychological bias and differential civil jury awards.

Originality/value
Because demographic information is not easily available, there is very little research on race and gender bias in civil cases. This study introduces and provides a conceptual test of a novel framework for when bias is most likely to impact damage awards in these cases and tests it using advances in social demography that can help researchers overcome this barrier.
Functional traits in red flour beetles: the dispersal phenotype is associated with leg length but not body size nor metabolic rate
Authors: Arnold Pieter A. , Cassey Phillip , White Craig R. 
Published: September 2016

Summary

Individuals vary in their ability to disperse. Much of this variation can be described by covarying phenotypic traits that are related to dispersal (constituting the ‘dispersal phenotype’ or ‘dispersal syndrome’), but the nature of the associations among these traits is not well understood. Unravelling the associations among traits that potentially constitute the dispersal phenotype provides a foundation for understanding evolutionary trade‐offs due to variation in dispersal.

Here, we tested five predictions pertaining to the relationships among physiological, morphological and movement traits that are associated with dispersal, using a species with a long history as a laboratory model for studying ecological phenomena, red flour beetles (Tribolium castaneum).

We identified a dominant axis of movement ability that describes variation in dispersal‐related movement traits. Individuals that scored positively on this axis moved at higher speed, travelled longer distances, had lower movement intermittency and dispersed quicker to a specified area.

Relative leg length, but not body size nor routine metabolic rate related positively with movement ability, indicating a likely mechanistic relationship between increased stride length and movement ability.

Our data suggest that the dispersal phenotype may be more strongly linked to morphological traits than physiological ones. We demonstrate that associations among many functional traits do not necessarily conform to a priori expectations, and predict that the substantial intraspecific variation in trait values may be important for selection. Movement is a complex behavioural trait, but it has a mechanistic basis in locomotor morphology that warrants further exploration.

A lay summary is available for this article.
Neotypification of Dothistroma septosporum and epitypification of D. pini, causal agents of Dothistroma needle blight of pine
Authors: Barnes I. , van der Nest A. , Mullett M. S. , Crous P. W. , Drenkhan R. , Musolin D. L. , Wingfield M. J. 
Published: September 2016

SummaryDothistroma needle blight (DNB) is one of the most devastating needle diseases on Pinus spp. worldwide. Ever since the description of the causal agent of the disease in Europe in 1911 as Cytosporina septospora, and independently in the USA in 1941 as Dothistroma pini, there has been considerable taxonomic discordance regarding the name of the pathogen used in literature. This was compounded both by the proposal of different varieties of the pathogen based on differences in spore size and the application of dual nomenclature where three names, Scirrhia pini, Eruptio pini and Mycosphaerella pini, were used to describe the sexual morph of the fungus. More recent studies using sequence‐based methods revealed that DNB can be caused by either one of two distinct species, that is D. septosporum and D. pini. These important species have not been adequately typified, and this perpetuates lack of stability for their names. In this study, these names are fixed to reference sequences linked to living cultures representing type specimens. To achieve this goal, we designate an epitype for D. pini and a neotype for D. septosporum. The known polymorphism in the ITS region, the barcoding gene for these fungi, is characterized and a complete taxonomic history is provided for the genus Dothistroma.
Biodiversity monitoring by community‐based restoration groups in New Zealand
Authors: Sullivan Jon J. , Molles Laura E. 
Published: September 2016

SummaryIn recent decades, community groups have transformed habitat restoration, pest control and species translocations in New Zealand. Large areas of wild New Zealand benefit hugely from ongoing management by community‐based restoration groups. Areas near cities and towns have especially good access to pools of keen volunteers. Community groups are involved in monitoring progress with their work, as well as monitoring biodiversity changes in general at their project sites. New tools powered by modern technologies are creating the opportunity for New Zealand's community volunteers to play a transformative role in biodiversity monitoring for either purpose. These tools are reducing the resources and expertise required for species detection and identification. Smartphones with cameras, GPS, audio recorders and data apps make it easier than ever to record species observations. Crowd‐sourced identification of species in photographs and sounds loaded onto NatureWatch NZ allow volunteers to make observations of a much wider range of taxa than just common birds and trees. Realising this potential requires community groups, scientists and their institutions to collaborate in building and maintaining simple, accessible monitoring systems that (i) require and promote standard monitoring methods, (ii) provide efficient data entry in standard formats, (iii) generate automated results of use to community groups and (iv) facilitate public sharing of data to contribute to regional, national and global biodiversity monitoring. Some New Zealand monitoring systems developed recently to assist community‐based restoration groups with monitoring mammalian predator control are good examples of this approach. Making this happen at a large scale across many community groups and taxa requires increased and coordinated long‐term institutional support for monitoring systems and training.