bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: REACTIONS OF ACETYLENIC ESTERS WITH CYCLIC KETONES AND SUBSTITUTED ACETOPHENONES
Authors: SHANDALA M. Y. , AL‐KHASHAB A.‐E. Y. , AL‐JOBOUR N. H. , AL‐ARAB M. M. 
Published: April 2016

AbstractDie Kondensation der substituierten Phenylpropiolsäureester (II) mit den Cyclischen Ketonen (III) führt zu dem 4‐Pyron (I) bzw. den 2‐Pyronen (IV).
ChemInform Abstract: SYNTHESIS OF NEWER XANTHOTOXIN DERIVATIVES WITH POTENTIAL ANTIBACTERIAL EFFECTS
Authors: ATTIA A. , ISLAM A. M. , EL‐MAGHRABY A. M. , AMMAR Y. 
Published: April 2016

AbstractDurch Rückflußkochen von Xanthotoxin‐4‐sulfonylchlorid mit Aminen wurden die Sulfonamide (II) dargestellt.
ChemInform Abstract: SYNTHESIS OF SOME 3‐METHYLBUT‐2‐ENYLATED 1,3,5‐TRIHYDROXYXANTHONES
Authors: GUJRAL V. , GUPTA S. R. 
Published: April 2016

AbstractDas Trihydroxyxanthenon (I) reagiert mit einem Methylbutenol in Gegenwart einer katalytischen Menge von BF3‐Et2 O zu einer Mischung aus (IIa ‐ c) neben unumgesetztem (I).
ChemInform Abstract: SYNTHESIS OF 7,8‐DIHYDROQUINOLINONES
Authors: MAQUESTIAU A. , VAN HAVERBEKE Y. , VANDEN EYNDE J.‐J. , DE PAUW N. 
Published: April 2016

AbstractDie Kondensation des Aminocyclohexenons (I) mit asymm. substituierten 1,3‐Diketonen (II) verläuft regiospezifisch zu den 7,8‐Dihydrochinolonen (III).
ChemInform Abstract: MODIFIED TETRAHELICENE SYSTEMS. III. DOUBLY ORTHO‐BRIDGED TRIPHENYLAMINE DERIVATIVES
Authors: HELLWINKEL D. , SCHMIDT W. 
Published: April 2016

AbstractFür detaillierte Untersuchungen des strukturabhängigen Racemisierungs‐ ′ verhaltens (Thermodynamik (Ermittlung der Racemisierungsbarrieren); eingehende Diskussion) bzw. im Zusammenhang damit werden die Verbindungen (Ib)‐(Im), (IV), (VI), (VIII), (IX), (Xb) und (XIV) dargestellt: Nitrierung von (Ia) (bekannt) unter verschiedenen Bedingungen liefert (Ib)‐(If); Reduktion von (Ib) bzw. (If) gibt (Ig) [→(Ih)] bzw. (Ii) [→(Ij)]; (II) und (Im) sind aus (Ia) erhältlich; (Ik) wird aus dem Diester (II) über die Stufe (III) dargestellt; (IVa) ist analog zugänglich; (IVb) wird aus der Verbindung (V) gewonnen und wird in die Verbindungen (VI) übergefuhrt; die Heterocyclen (IVe) werden aus (VIIa) dargestellt; (VIIb) liefert das Derivat (VIII) (Isomerengemisch).
ChemInform Abstract: REACTION OF AMIDOXIMES WITH DIPHENYLCYCLOPROPENONE. SYNTHESIS OF 2‐ARYL‐5,6‐DIPHENYLPYRIMIDIN‐4‐ONES
Authors: TAKAHASHI M. , WATANABE S. 
Published: April 2016

AbstractDie Arylamidoxime (I) reagieren mit Diphenylcyclopropenon (II) in siedendem Toluol zu den Pyrimidinonen (III), von denen der Phenylvertreter auch aus dem Oxazinon (IV) und wäßrigem Ammoniak entsteht.
ChemInform Abstract: SIMPLE SYNTHESIS OF NOVEL 1,3,9‐TRIAZAANTHRACENES
Authors: CAPUANO L. , BRONDER M. , DJOKAR K. , MUELLER I. + 
Published: April 2016

AbstractWittig‐Reaktion des Bromacetats (I) mit den Isocyanaten (IV) liefert die noch nicht beschriebenen Triazaanthracene (VIII) und oder (XII).
ChemInform Abstract: NUCLEOPHILIC SUBSTITUTIONS WITH BIS(CHLORONITROSO)COMPOUNDS. III. REACTIONS WITH SALTS AND ESTERS OF DITHIOCARBAZIC ACID AND N‐PHENYLDITHIOCARBAZIC ACID
Authors: BEGER J. , THIELEMANN C. , THONG P. D. 
Published: April 2016

AbstractDie Titelverbindungen (I) reagieren mit den Salzen der Dithiocarbazinsäuren (II) zu deren Estern (III), wobei in einigen Fällen die Umsetzung ohne Erhitzen vorgenommen werden muß.
ChemInform Abstract: VICINAL DEHYDROBROMINATION OF (α‐BROMOVINYL)CHLOROSILANES WITH QUINOLINE. A NEW ROUTE TO ETHYNYLCHLOROSILANES
Authors: MATSUMOTO H. , KATO T. , MATSUBARA I. , HOSHINO Y. , NAGAI Y. 
Published: April 2016

AbstractMit Chinolin lassen sich die Bromvinylchlorsilane (I) zu den Ethinylderivaten (II) dehydrobromieren.
ChemInform Abstract: REACTIONS OF (DICHLOROPHOSPHINYL)METHANESULFONYL CHLORIDE
Authors: FILD M. , RIECK H.‐P. 
Published: April 2016

AbstractDie Substitution von C1 durch F in dem nach bekannter Methode synthetisierten Phosphinylmethansulfonylchlorid (I) wird mit AsF3 erreicht und liefert abhängig von der Reaktionstemp. und ‐dauer das Fluoiid (IIa) oder (IIb).
ChemInform Abstract: NUCLEOPHILIC PHOSPHORYLATION OF CHLORO DERIVATIVES OF 5‐NITROPYRIMIDINES
Authors: ONYS'KO P. P. , GOLOLOBOV YU. G. , CHERKASOV V. M. , BOLDYREV I. V. 
Published: April 2016

AbstractTrialkylphosphite (II) reagieren mit den 4‐substituierten 5‐Nitro‐6‐chlorpyrimidinen (Ia) und (Ib) zu den entsprechenden 5‐Nitro‐6‐dialkylphosphoryl‐pyrimidinen (IIIa) und (IIIb).
ChemInform Abstract: SYNTHESIS AND REACTIONS OF BINUCLEAR MOLYBDENOCENE AND TUNGSTENOCENE DERIVATIVES
Authors: BERRY M. , COOPER N. J. , GREEN M. L. H. , SIMPSON S. J. 
Published: April 2016

AbstractDas Tetramere (I) reagiert mit N2O zu einer Mischung der Verbindungen (II) und (III), die als ein cis‐ und ein trans‐Isomeres angesehen werden, ohne daß eine Zuordnung erfolgt.
ChemInform Abstract: SYNTHETIC STUDIES TOWARD COMPLEX DITERPENOIDS. STEREOCONTROLLED TOTAL SYNTHESIS OF SOME GIBBANE SYNTHONS AND DEGRADATION PRODUCTS OF GIBBERELLINS
Authors: GHATAK U. R. , CHAKRABORTI P. C. 
Published: April 2016

AbstractDas Indanon (I) reagiert mit Vinylgrignardreagens zum Addukt (II), das nach Dehydratisierung zum Dien (III) mit den Acrylestern (IV) zu den isomeren Fluorencarbonsäurederivaten (V)‐(VIII) führt.
ChemInform Abstract: SYNTHESIS OF OCIMENOL AND RELATED COMPOUNDS FROM 5‐CHLORO‐2‐PENTANONE
Authors: KISE H. , SATO T. , YASUOKA T. , SENO M. , ASAHARA T. 
Published: April 2016

Abstract5‐Chlor‐2‐pentanon (I) und Vinylmagnesiumbromid (II) geben das Addukt (III), aus dem die isomeren Diene (IV) und (V) zugänglich sind.
ChemInform Abstract: STUDIES ON STEROIDS. PART CLI. STEREOSELECTIVE HYDROGEN ELIMINATION AT C‐2 IN N THE TRANSFORMATION OF 5β‐PREGNANE‐3,11,20‐TRIONE BY SEPTOMYXA AFFINIS
Authors: IKEGAWA S. , HINO Y. , NAMBARA T. 
Published: April 2016

AbstractBei der Dehydrierung der Pregnant?one (I) mit Septomyxa af?nis entstehen hauptsächlich die beiden Steroide (II) und (III).
ChemInform Abstract: THE SYNTHESES OF HUMAN BIG GASTRIN I AND ITS 32‐LEUCINE ANALOG. 3. PREPARATION OF THE FULLY PROTECTED (TETRATRIACONTAPEPTIDE AMIDE) SEQUENCES
Authors: WENDLBERGER G. , MORODER L. , HALLETT A. , WUENSCH E. + 
Published: April 2016

Abstract1. Mit Hilfe der in den vorangehenden Mitt. beschriebenen synthetisierten Fragmente (I), (II), (IV), (VI), (VII) und (X) wird wie im Formelschema angegeben (außerdem werden 2 weitere alternative Reaktionswege mit ähnlichen Gesamtausb· beschrieben) die Gesamtsequenz (XI) von Human‐Big‐Gastrin I synthetisiert.
ChemInform Abstract: NUCLEOSIDES. 112. SYNTHESIS OF SOME NEW PYRAZOLO(1,5‐A)‐1,3,5‐TRIAZINES AND THEIR C‐NUCLEOSIDES
Authors: TAM S. Y. K. , KLEIN R. S. , WEMPEN I. , FOX J. J. 
Published: April 2016

AbstractAus den Pyrazolotriazinen (I) entsteht das Thiono‐Derivat (II), das zu (III) methyliert und dann mit Hydroxylamin zu (IV) ausgetauscht werden kann.
Slotted plate device to measure the yield stress of biofluids
Authors: De Kee Daniel , Rice David , Leissinger Cindy , Meng Bin 
Published: April 2016

AbstractThe slotted plate device by Zhu et al.1,2 was redesigned to allow for the measurement of very low yield stress values that occur with complex biofluids. The newly built apparatus improves the force measurement with a balance of fine resolution and smooths the vertical motion via a lab jack. The slotted plate geometry was optimized to further reduce wall slip as well as pressure drag via computational fluid dynamics (CFD). To improve on the yield stress measurement accuracy, the new design has a large slot area ratio and a large number of slots, as well as sharp front and rear edges. Test results for a few structured fluids, including blood, are compared with yield stress values determined via a TA Instruments AR‐2000 rheometer.
Bayesian inference for high‐dimensional linear regression under mnet priors
Authors: Tan Aixin , Huang Jian 
Published: April 2016

AbstractFor regression problems that involve many potential predictors, the Bayesian variable selection (BVS) method is a powerful tool. This method associates each model with its posterior probability and achieves excellent prediction performance through Bayesian model averaging. The main challenges of using such models include specifying a suitable prior and computing posterior quantities for inference. We contribute to the literature of BVS modelling in the following aspects. We first propose a new family of priors, called the mnet prior, which is indexed by a few hyperparameters that allow great flexibility in the prior density. The hyperparameters can also be treated as random, so that their values need not be tuned manually, but will instead adapt to the data. Simulation studies are used to demonstrate good prediction and variable selection performances of these models. Secondly, the analytical expression of the posterior distribution is unavailable for the BVS model under the mnet prior in general, as is the case for most BVS models. We develop an adaptive Markov chain Monte Carlo algorithm that facilitates the computation in high‐dimensional regression problems. We finally showcase various ways to do inference with BVS models, highlighting a new way to visualize the importance of each predictor along with estimation of the coefficients and their uncertainties. These are demonstrated through the analysis of a breast cancer gene expression dataset.The Canadian Journal of Statistics44: 180–197; 2016 © 2016 Statistical Society of Canada
Cytologic features of angiosarcoma: A review of 26 cases diagnosed on FNA
Authors: Geller Rachel L. , Hookim Kim , Sullivan Harold C. , Stuart Lauren N. , Edgar Mark A. , Reid Michelle D. 
Published: April 2016

BACKGROUNDThis study describes the cytologic features of 26 angiosarcomas diagnosed on fine‐needle aspiration.METHODSTwenty‐six angiosarcomas from 20 patients were confirmed by cytomorphology and immunocytochemical (immunohistochemistry) positivity for at least 2 of 3 vascular markers. Specimens were examined for spindled/epithelioid/plasmacytoid single cells, 3‐dimensional clusters, multiple prominent/bar‐shaped nucleoli (5 times longer than their width), chromatin strands, abnormal mitoses, necrosis, and vasoformative features.RESULTSEight males and 12 females with a mean age of 52 years (range, 2‐94 years) underwent aspiration of tumors in the following: soft tissue or skin/subcutis (n = 10), bone (n = 4), nodes (n = 5), lung (n = 2), liver (n = 2), heart (n = 1), parotid gland (n = 1), and pleural fluid (n = 1). An angiosarcoma diagnosis was rendered for 24 of the 26 cases (92%); 1 was diagnosed as “atypical cells, cannot exclude angiosarcoma,” and another was diagnosed as a malignant vascular neoplasm. Abnormal mitoses were most frequent (85%), and they were followed by single malignant cells (81%: epithelioid [69%], spindled [62%], and plasmacytoid [19%]), 3‐dimensional clusters (54%), multiple prominent (62%) or bar‐shaped nucleoli (54%), and chromatin strands (31%). Vasoformative features, including hemophagocytosis (54%), cytoplasmic lumina/vacuoles (69%) containing red blood cells (54%)/neutrophils (31%), and endothelial wrapping (69%), were seen in 88%; 23% had all vasoformative features, 88% had at least 1, and 12% had none.CONCLUSIONSAngiosarcomas show a range of cytomorphologic features that make them potentially recognizable on cytology. Although vasoformative features are highly suggestive, they are not specific for angiosarcoma and may be seen in some nonvascular neoplasms. Immunohistochemistry and a high index of suspicion are required for an accurate diagnosis. Cancer Cytopathol 2016;124:659–68. © 2016 American Cancer Society.
Multimodality imaging‐guided left ventricular lead placement in cardiac resynchronization therapy: a randomized controlled trial
Authors: Sommer Anders , Kronborg Mads Brix , Nørgaard Bjarne Linde , Poulsen Steen Hvitfeldt , Bouchelouche Kirsten , Böttcher Morten , Jensen Henrik Kjærulf , Jensen Jesper Møller , Kristensen Jens , Gerdes Christian , Mortensen Peter Thomas , Nielsen Jens Cosedis 
Published: April 2016

AbstractAimLeft ventricular (LV) lead position at the latest mechanically activated non‐scarred myocardial LV region confers improved response to cardiac resynchronization therapy (CRT). We conducted a double‐blind, randomized controlled trial to evaluate the clinical benefit of multimodality imaging‐guided LV lead placement in CRT.Methods and resultsPatients were allocated (1:1) to imaging‐guided LV lead placement using cardiac computed tomography (CT) venography, 99mTechnetium myocardial perfusion imaging, and speckle‐tracking echocardiography radial strain to target the optimal coronary sinus (CS) branch closest to the non‐scarred myocardial segment with latest mechanical activation (imaging group, n = 89) or to routine LV lead implantation in a posterolateral region with late electrical activation (control group, n = 93). The primary endpoint was clinical non‐response to CRT [≥1 of the following after 6 months: (1) death, (2) heart failure hospitalization, or (3) no improvement in New York Heart Association class and <10% increase in 6‐min walk distance]. Secondary outcomes included LV remodelling and the combination of all‐cause mortality and hospitalization owing to heart failure during 1.8 ± 0.9 years. Analysis was intention‐to‐treat. In the imaging group, fewer patients reached the primary endpoint (26% vs. 42%, P = 0.02). More patients in the imaging group had the LV lead placed in the optimal CS branch (83% vs. 65%, P = 0.01). There were no between‐group differences in reverse LV remodelling or the combined endpoint of death or hospitalizations for heart failure.ConclusionsMultimodality imaging‐guided LV lead placement towards the CS branch closest to latest mechanically activated non‐scarred myocardial LV segment reduces the proportion of clinical non‐responders to CRT. Larger long‐term multicentre studies are needed.
Deep‐Red Phosphorescent Iridium(III) Complexes with Chromophoric N‐Heterocyclic Carbene Ligands: Design, Photophysical Properties, and DFT Calculations
Authors: Lanoë Pierre‐Henri , Chan Jonny , Gontard Geoffrey , Monti Filippo , Armaroli Nicola , Barbieri Andrea , Amouri Hani 
Published: April 2016

AbstractInvited for the cover of this issue are the groups of Hani Amouri at Université Pierre et Marie Curie, Paris, France, and Andrea Barbieri at the CNR, Bologna, Italy. The cover image shows an octahedral cyclometalated iridium complex containing an N‐heterocyclic carbene attached to a naphthalimide chromophore.
Reaction performance study on denitration in aqueous solution of the dual oxidant (H2O2/S2)
Authors: Wang Zhiping , Wang Zuwu 
Published: April 2016

The reaction performance study on NO removal by using the dual oxidant (H2O2/S2) solution was carried out in self‐designed bubbling reactor. The experimental results showed that NO removal efficiency was up to 92.9% at pH 11. The results of the thermodynamics calculation verified that NO removal by using strong alkaline dual oxidant (H2O2/S2) solution was feasible. The results of the kinetic study showed that the reaction between NO and dual oxidant (H2O2/S2) in strong alkaline condition was found to be 1.5‐order with respect to NO, and the average activation energy of this reaction was 26.32 kJ mol−1in the quick‐reaction zone. The ion chromatography (IC) analysis results in strong alkaline condition showed thatandwere the final ionic product in spent reaction solution. This dual oxidant (H2O2/S2) was a promising oxidant for the simultaneous wet removal of NO and SO2with high efficiency, no secondary pollution and low cost. © 2016 American Institute of Chemical Engineers Environ Prog, 35: 1361–1366, 2016
Nanomaterials in the aquatic environment: A European Union–United States perspective on the status of ecotoxicity testing, research priorities, and challenges ahead
Authors: Selck Henriette , Handy Richard D. , Fernandes Teresa F. , Klaine Stephen J. , Petersen Elijah J. 
Published: April 2016

Abstract

The European Union–United States Communities of Research were established in 2012 to provide a platform for scientists to develop a “shared repertoire of protocols and methods to overcome nanotechnology environmental health and safety (nanoEHS) research gaps and barriers” (www.us-eu.org/). Based on work within the Ecotoxicology Community of Research (2012–2015) the present Focus article provides an overview of the state of the art of nanomaterials (NMs) in the aquatic environment by addressing different research questions, with a focus on ecotoxicological test systems and the challenges faced when assessing NM hazards (e.g., uptake routes, bioaccumulation, toxicity, test protocols, and model organisms). The authors' recommendation is to place particular importance on studying the ecological effects of aged/weathered NMs, as-manufactured NMs, and NMs released from consumer products in addressing the following overarching research topics: 1) NM characterization and quantification in environmental and biological matrices; 2) NM transformation in the environment and consequences for bioavailability and toxicity; 3) alternative methods to assess exposure; 4) influence of exposure scenarios on bioavailability and toxicity; 5) development of more environmentally realistic bioassays; and 6) uptake, internal distribution, and depuration of NMs. Research addressing these key topics will reduce uncertainty in ecological risk assessment and support the sustainable development of nanotechnology. Environ Toxicol Chem 2016;35:1055–1067. © 2016 SETAC
Critical rainfall statistics for predicting watershed flood responses: rethinking the design storm concept
Authors: Knighton James O. , Walter M. Todd 
Published: April 2016

AbstractRecent advances have been made to modernize estimates of probable precipitation scenarios; however, researchers and engineers often continue to assume that rainfall events can be described by a small set of event statistics, typically average intensity and event duration. Given the easy availability of precipitation data and advances in desk‐top computational tools, we suggest that it is time to rethink the ‘design storm’ concept. Design storms should include more holistic characteristics of flood‐inducing rain events, which, in addition to describing specific hydrologic responses, may also be watershed or regionally specific.We present a sensitivity analysis of nine precipitation event statistics from observed precipitation events within a 60‐year record for Tompkins County, NY, USA. We perform a two‐sample Kolmogorov–Smirnov (KS) test to objectively identify precipitation event statistics of importance for two related hydrologic responses: (1) peak outflow from the Six Mile Creek watershed and (2) peak depth within the reservoir behind the Six Mile Creek Dam. We identify the total precipitation depth, peak hourly intensity, average intensity, event duration, interevent duration, and several statistics defining the temporal distribution of precipitation events to be important rainfall statistics to consider for predicting the watershed flood responses. We found that the two hydrologic responses had different sets of statistically significant parameters.We demonstrate through a stochastic precipitation generation analysis the effects of starting from a constrained parameter set (intensity and duration) when predicting hydrologic responses as opposed to utilizing an expanded suite of rainfall statistics. In particular, we note that the reduced precipitation parameter set may underestimate the probability of high stream flows and therefore underestimate flood hazard. Copyright © 2016 John Wiley & Sons, Ltd.
In situ supramolecular hydrogel based on hyaluronic acid and dextran derivatives as cell scaffold
Authors: Chen Jing‐Xiao , Cao Lu‐Juan , Shi Yu , Wang Ping , Chen Jing‐Hua 
Published: April 2016

AbstractIn this study, hyaluronic acid‐β‐cyclodextrin conjugate (HA‐CD) and dextran‐2‐naphthylacetic acid conjugate (Dex‐NAA) were synthesized as two gelators. The degrees of substitution (DS) of these two gelators were determined to be 15.5 and 7.4%, respectively. Taking advantages of the strong and selective host–guest interaction between β‐CD and 2‐NAA, the mixture of two gelators could form supramolecular hydrogel in situ. Moreover, the pore size, gelation time, swelling ratio as well as modulus of the hydrogel could be adjusted by simply varying the contents of HA‐CD and Dex‐NAA. NIH/3T3 cells that entrapped in hydrogel grew well as compared with that cultured in plates, indicating a favorable cytocompatibility of the hydrogel. Collectively, the results demonstrated that the HA‐Dex hydrogel could potentially be applied in tissue engineering as cell scaffold. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2263–2270, 2016.
A microscopy method for scanning transmission electron microscopy imaging of the antibacterial activity of polymeric nanoparticles on a biofilm with an ionic liquid
Authors: Takahashi Chisato , Muto Shunsuke , Yamamoto Hiromitsu 
Published: April 2016

AbstractIn this study, we developed a scanning transmission electron microscopy (STEM) method for imaging the antibacterial activity of organic polymeric nanoparticles (NPs) toward biofilms formed by Staphylococcus epidermidis bacterial cells, for optimizing NPs to treat biofilm infections. The combination of sample preparation method using a hydrophilic ionic liquid (IL) and STEM observation using the cooling holder eliminates the need for specialized equipment and techniques for biological sample preparation. The annular dark‐field STEM results indicated that the two types of biodegradable poly‐(DL‐lactide‐co‐glycolide) (PLGA) NPs: PLGA modified with chitosan (CS), and clarithromycin (CAM)‐loaded + CS‐modified PLGA, prepared by emulsion solvent diffusion exhibited different antibacterial activities in nanoscale. To confirm damage to the sample during STEM observation, we observed the PLGA NPs and the biofilm treated with PLGA NPs by both the conventional method and the newly developed method. The optimized method allows microstructure of the biofilm treated with PLGA NPs to be maintained for 25 min at a current flow of 40 pA. The developed simple sample preparation method would be helpful to understand the interaction of drugs with target materials. In addition, this technique could contribute to the visualization of other deformable composite materials at the nanoscale level. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1432–1437, 2017.
Time course of surface characteristics of alkali‐ and heat‐treated titanium dental implants during vacuum storage
Authors: Kamo Michimasa , Kyomoto Masayuki , Miyaji Fumiaki 
Published: April 2016

AbstractCurrent efforts to shorten the healing times of life‐long dental implants and prevent their fouling by organic impurities have focused on using surface‐modification treatments and alternative packaging, respectively. In this study, we investigated the time course of the surface characteristics, including the wettability, a protein‐adsorption and apatite‐formation abilities, of alkali‐ and heat‐treated (AH‐treated) Ti samples during storage in vacuum over a period of 52 weeks. The AH treatment resulted in the formation of a nanometer‐scale needle‐like rougher surface of the Ti samples. Although the water contact angle of the AH‐treated Ti sample increased slightly, it remained as low as approximately 10° even after storage in vacuum for 52 weeks. There was no significant difference in the protein‐adsorption and apatite‐formation abilities of the AH‐treated Ti sample before and after storage. Further, the AH‐treated Ti sample exhibited greater protein‐adsorption and apatite‐formation abilities compared with the untreated one; regardless of the samples stored in vacuum or not. Apatite formed only on the AH‐treated Ti surface. Therefore, subjecting Ti dental implants to the AH treatment and storing them in vacuum should help prevent their surfaces from getting contaminated. Further, it is expected that AH‐treated Ti dental implants controllably aged during a shelf storage will exhibit high stability and bone‐bonding bioactivity. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1453–1460, 2017.