bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does superior caval vein pressure impact head growth in Fontan circulation?
Authors: Trachsel Tina , Balmer Christian , Wåhlander Håkan , Weber Roland , Dave Hitendu , Poretti Andrea , Kretschmar Oliver , Cavigelli-Brunner Anna 
Published: January 2016

AbstractBackgroundPatients with bidirectional cavopulmonary anastomosis have unphysiologically high superior caval vein pressure as it equals pulmonary artery pressure. Elevated superior caval vein pressure may cause communicating hydrocephalus and macrocephaly. This study analysed whether there exists an association between head circumference and superior caval vein pressure in patients with single ventricle physiology.MethodsWe carried out a retrospective analysis of infants undergoing Fontan completion at our institution from 2007 to 2013. Superior caval vein pressures were measured during routine catheterisation before bidirectional cavopulmonary anastomosis and Fontan completion as well as head circumference, adjusted to longitudinal age-dependent percentiles.ResultsWe included 74 infants in our study. Median ages at bidirectional cavopulmonary anastomosis and Fontan were 4.8 (1.6–12) and 27.9 (7–40.6) months, respectively. Head circumference showed significant growth from bidirectional cavopulmonary anastomosis until Fontan completion (7th (0–100th) versus 20th (0–100th) percentile). There was no correlation between superior caval vein pressure and head circumference before Fontan (R2=0.001). Children with lower differences in superior caval vein pressures between pre-bidirectional cavopulmonary anastomosis and pre-Fontan catheterisations showed increased growth of head circumference (R2=0.19).ConclusionsPatients with moderately elevated superior caval vein pressure associated with single ventricle physiology did not have a tendency to develop macrocephaly. There is no correlation between superior caval vein pressure before Fontan and head circumference, but between bidirectional cavopulmonary anastomosis and Fontan head circumference increases significantly. This may be explained by catch-up growth of head circumference in patients with more favourable haemodynamics and concomitant venous pressures in the lower range. Further studies with focus on high superior caval vein pressures are needed to exclude or prove a correlation.
Crop diversity and plant–plant interactions in urban allotment gardens
Authors: Woods Matthew E. , Ata Rehman , Teitel Zachary , Arachchige Nishara M. , Yang Yi , Raychaba Brian E. , Kuhns James , Campbell Lesley G. 
Published: January 2016

AbstractAllotment food gardens represent important sources of food security for urban residents. Since urban gardeners rarely receive formal agricultural education and have extremely limited space, they may be relying on readily available gardening advice (e.g., seed packet instructions), inventing cultural strategies that consider inter-specific competitive dynamics, or making poor planting decisions. Knowledge of garden crop diversity and planting arrangements can aid in designing strategies for productive urban gardens and food systems. We surveyed 96 individual plots in 10 allotment gardens in the Toronto region, assessed crop diversity within gardens and recorded planting practices used by urban gardeners by measuring the proximity of individual plants relative to similar or different crop species. We also compared planting densities used by urban gardeners with those recommended by major seed distributers. Collectively, Toronto urban agriculture contributes substantially to urban plant diversity (108 crops), but each plot tends to be relatively depauperate. Carrots and lettuce were three to five times more likely to be planted in clusters than intermingled with other crops (P< 0.05); whereas gardeners did not appear to use consistent planting arrangements for tomatoes or zucchini. Gardeners tended to plant tomatoes and zucchini 56–62.5% more densely than recommended by seed distributers (P< 0.001), whereas they planted 147 times fewer carrots in a given area than recommended (P< 0.05). Furthermore, neither crop planting density nor crop diversity changed with plot size. The planting arrangements we have documented suggest gardeners using allotment plots attempt plant densely in extremely limited space, and are employing cultural strategies that intensify competitive dynamics within gardens. Future research should assess the absolute and relative effect of altered cultural practices on yield, such that any modifications can be prioritized by their impact on yield.
Chronic and remitting trajectories of depressive symptoms in the elderly. Characterisation and risk factors
Authors: Carrière I. , Farré A. , Proust-Lima C. , Ryan J. , Ancelin M.L. , Ritchie K. 
Published: January 2016

Background.In elderly general population sub-syndromal clinically significant levels of depressive symptoms are highly prevalent and associated with high co-morbidity and increased mortality risk. However changes in depressive symptoms over time and etiologic factors have been difficult to characterise notably due to methodological shortcomings. Our objective was to differentiate trajectories of depressive symptoms over 10 years in community-dwelling elderly men and women using statistical modelling methods which take into account intra-subject correlation and individual differences as well as to examine current and life-time risk factors associated with different trajectories.Methods.Participants aged 65 and over were administered standardised questionnaires and underwent clinical examinations at baseline and after 2, 4, 7 and 10 years. Trajectories over time of the Center for Epidemiologic Studies Depression scores were modelled in 517 men and 736 women separately with latent class mixed models which include both a linear mixed model to describe latent classes of trajectories and a multinomial logistic model to characterise the latent trajectories according to baseline covariates (socio-demographic, lifestyle, clinical, genetic characteristics and stressful life events).Results.In both genders two different profiles of symptom changes were observed over the 10-year follow-up. For 9.1% of men and 25% of women a high depressive symptom trajectory was found with a trend toward worsening in men. The majority of the remaining men and women showed decreasing symptomatology over time, falling from clinically significant to very low levels of depressive symptoms. In large multivariate class membership models, mobility limitations [odds ratio (OR) = 4.5, 95% confidence interval (CI) 1.6–12.9 and OR = 4.9, 95% CI 2.3–10.7, in men and women respectively], ischemic pathologies (OR = 2.9, 95% CI 1.0–8.3 and OR = 3.1, 95% CI 1.0–9.9), and recent stressful events (OR = 4.5, 95% CI 1.1–18.5, OR = 3.2, 95% CI 1.6–6.2) were associated with a poor symptom course in both gender as well as diabetes in men (OR = 3.5, 95% CI 1.1–10.9) and childhood traumatic experiences in women (OR = 3.1, 95% CI 1.6–5.8).Conclusions.This prospective study was able to differentiate patterns of chronic and remitting depressive symptoms in elderly people with distinct symptom courses and risk factors for men and women. These findings may inform prevention programmes designed to reduce the chronic course of depressive symptomatology.
miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth
Authors: Fulciniti M , Amodio N , Bandi R L , Cagnetta A , Samur M K , Acharya C , Prabhala R , D'Aquila P , Bellizzi D , Passarino G , Adamia S , Neri A , Hunter Z R , Treon S P , Anderson K C , Tassone P , Munshi N C 
Published: January 2016

AbstractDeregulated microRNA (miR)/transcription factor (TF)-based networks represent a hallmark of cancer. We report here a novel c-Myc/miR-23b/Sp1 feed-forward loop with a critical role in multiple myeloma (MM) and Waldenstrom’s macroglobulinemia (WM) cell growth and survival. We have found miR-23b to be downregulated in MM and WM cells especially in the presence of components of the tumor bone marrow milieu. Promoter methylation is one mechanism of miR-23b suppression in myeloma. In gain-of-function studies using miR-23b mimics-transfected or in miR-23b-stably expressing MM and WM cell lines, we observed a significant decrease in cell proliferation and survival, along with induction of caspase-3/7 activity over time, thus supporting a tumor suppressor role for miR-23b. At the molecular level, miR-23b targeted Sp1 3′UTR and significantly reduced Sp1-driven nuclear factor-κB activity. Finally, c-Myc, an important oncogenic transcription factor known to stimulate MM cell proliferation, transcriptionally repressed miR-23b. Thus MYC-dependent miR-23b repression in myeloma cells may promote activation of oncogenic Sp1-mediated signaling, representing the first feed-forward loop with critical growth and survival role in myeloma.
Infectious complications in children with acute myeloid leukemia: decreased mortality in multicenter trial AML-BFM 2004
Authors: Bochennek K , Hassler A , Perner C , Gilfert J , Schöning S , Klingebiel T , Reinhardt D , Creutzig U , Lehrnbecher T 
Published: January 2016

AbstractInfections are an important cause for morbidity and mortality in pediatric acute myeloid leukemia (AML). We therefore characterized infectious complications in children treated according to the trial AML-BFM 2004. Patients with Down syndrome were excluded from the analysis. Data were gathered from the medical records in the hospital where the patients were treated. A total of 405 patients (203 girls; median age 8.4 years) experienced 1326 infections. Fever without identifiable source occurred in 56.1% of the patients and clinically and microbiologically documented infections in 17.5% and 32.4% of the patients, respectively. In all, 240 Gram-positive (112 viridans group streptococci) and 90 Gram-negative isolates were recovered from the bloodstream. Invasive fungal infection was diagnosed in 3% of the patients. Three children each died of Gram-negative bacteremia and invasive aspergillosis, respectively. As compared with the results of AML-BFM 93 with lower dose intensity, infection-related morbidity was slightly higher in AML-BFM 2004 (3.3. versus 2.8 infections per patient), whereas infection-related mortality significantly decreased (1.5% versus 5.4%; P=0.003). Specific anti-infective recommendations included in the treatment protocol, regular training courses for pediatric hematologists and increasing experience may be the reason for reduced infection-related mortality in children with AML. Further studies are needed to decrease infection-related morbidity.
Prognostic interaction between ASXL1 and TET2 mutations in chronic myelomonocytic leukemia
Authors: Patnaik M M , Lasho T L , Vijayvargiya P , Finke C M , Hanson C A , Ketterling R P , Gangat N , Tefferi A 
Published: January 2016

AbstractMutations involving epigenetic regulators (TET2~60% and ASXL1~40%) and splicing components (SRSF2~50%) are frequent in chronic myelomonocytic leukemia (CMML). On a 27-gene targeted capture panel performed on 175 CMML patients (66% males, median age 70 years), common mutations included: TET2 46%, ASXL1 47%, SRSF2 45% and SETBP1 19%. A total of 172 (98%) patients had at least one mutation, 21 (12%) had 2, 24 (14%) had 3 and 30 (17%) had >3 mutations. In a univariate analysis, the presence of ASXL1 mutations (P=0.02) and the absence of TET2 mutations (P=0.03), adversely impacted survival; while the number of concurrent mutations had no impact (P=0.3). In a multivariable analysis that included hemoglobin, platelet count, absolute monocyte count and circulating immature myeloid cells (Mayo model), the presence of ASXL1 mutations (P=0.01) and absence of TET2 mutations (P=0.003) retained prognostic significance. Patients were stratified into four categories: ASXL1wt/TET2wt (n=56), ASXL1mut/TET2wt (n=31), ASXL1mut/TET2mut (n=50) and ASXL1wt/TET2mut (n=38). Survival data demonstrated a significant difference in favor of ASXL1wt/TET2mut (38 months; P=0.016), compared with those with ASXL1wt/TET2wt (19 months), ASXL1mut/TET2wt (21 months) and ASXL1mut/TET2mut (16 months) (P=0.3). We confirm the negative prognostic impact imparted by ASXL1 mutations and suggest a favorable impact from TET2 mutations in the absence of ASXL1 mutations.
Karyotype complexity and prognosis in acute myeloid leukemia
Authors: Stölzel F , Mohr B , Kramer M , Oelschlägel U , Bochtler T , Berdel W E , Kaufmann M , Baldus C D , Schäfer-Eckart K , Stuhlmann R , Einsele H , Krause S W , Serve H , Hänel M , Herbst R , Neubauer A , Sohlbach K , Mayer J , Middeke J M , Platzbecker U , Schaich M , Krämer A , Röllig C , Schetelig J , Bornhäuser M , Ehninger G 
Published: January 2016

AbstractA complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our study demonstrated that (1) patients with a pure hyperdiploid karyotype have an adverse risk irrespective of the number of chromosomal gains, (2) patients with translocation t(9;11)(p21∼22;q23) have an intermediate risk independent of the number of additional aberrations, (3) patients with ⩾4 abnormalities have an adverse risk per se and (4) patients with three aberrations in the absence of abnormalities of strong influence (hyperdiploid karyotype, t(9;11)(p21∼22;q23), CBF-AML, unique adverse-risk aberrations) have borderline intermediate/adverse risk with a reduced overall survival compared with patients with a normal karyotype.
Annexin A1 localization and its relevance to cancer
Authors: Boudhraa Zied , Bouchon Bernadette , Viallard Claire , D'Incan Michel , Degoul Françoise 
Published: January 2016

Annexin A1 (ANXA1) is a Ca2+-regulated phospholipid-binding protein involved in various cell processes. ANXA1 was initially widely studied in inflammation resolution, but its overexpression was later reported in a large number of cancers. Further in-depth investigations have revealed that this protein could have many roles in cancer progression and act at different levels (from cancer initiation to metastasis). This is partly due to the location of ANXA1 in different cell compartments. ANXA1 can be nuclear, cytoplasmic and/or membrane associated. This last location allows ANXA1 to be proteolytically cleaved and/or to become accessible to its cognate partners, the formyl-peptide receptors. Indeed, in some cancers, ANXA1 is found at the cell surface, where it stimulates formyl-peptide receptors to trigger oncogenic pathways. In the present review, we look at the different locations of ANXA1 and their association with the deregulated pathways often observed in cancers. We have specifically detailed the non-classic pathways of ANXA1 externalization, the significance of its cleavage and the role of the ANXA1–formyl-peptide receptor complex in cancer progression.
Tourism destination competitiveness and innovation: the case of the Spanish Mediterranean coast.
Authors: García Sánchez A. , Siles López D. 
Published: January 2016

Abstract

This chapter focuses on competitiveness and innovation, with an application to the Spanish Mediterranean region. Building on a wide range of indicators, the chapter seeks to identify the main sources of tourism destination competitiveness. The most important factor for competitiveness identified is specialization, followed by services, tourists' assessment, culture, attractiveness and weather. The chapter also links the concepts of innovation and competitiveness, defining how the former variable can enhance the latter one.
Ecological modernization and environmental education: the case of Turkey.
Authors: Alİpour H. , Olya H. G. T. 
Published: January 2016

Abstract

This chapter investigates the role of environmental education for a sustainable tourism horizon, with an application to Turkey. The chapter explores how educational institutions help to conform to an environmental attachment in students, as a way of introducing and enlarging the presence of environmental convictions at the tourism industry level. The findings of the study revealed that students in general lacked environmental knowledge and awareness, which encompassed students of tourism as well. Such discouraging levels of knowledge about issues of climate change, energy production and pollution will hamper making pro-environmental choices as an essential embryonic environmental greening towards sustainable tourism development. In fact, mass tourism, with all the critique of its negative environmental impact, is going to stay; however, environmental education in the context of a knowledge-based platform and concurrent with TEM is an initiative to accommodate a more complex and ambiguous array of sustainability options within the tourism industry. This study should be considered a wake-up call for tourism educators at EMU that social equity, justice, ethics and environmentalism are values that demand their rightful place in the tourism curriculum. In the context of a knowledge-based platform and ecological modernization's call for institutional policy change, the present curriculum has remained short of an appreciation of the structural complexity and international nature of tourism as a socioeconomic, political and environmental phenomenon.
Finite element modelling of microstructural changes in dry and cryogenic machining AISI 52100 steel
Authors: Umbrello D. , Caruso S. , Imbrogno S. 
Published: January 2016

The paper presents the results of investigations of grain size and hardness variation induced by orthogonal machining of hardened AISI 52100 bearing steel in the white layer (WL). The experiments were performed under dry and cryogenic cooling conditions using honed cubic boron nitride tool inserts. The experimental results are compared with a newly developed finite element model to describe microstructural changes and dynamic recrystallisation. Furthermore, the numerical model will be able to suggest if the WL formation is mainly thermally induced through phase transformation or mainly mechanically induced through severe plastic deformation. An iterative procedure was utilised to experimentally calibrate and then validate the proposed model at varying cutting speeds and cutting cooling conditions (dry and cryogenic). This paper is part of a Themed Issue on Recent developments in bearing steels.
International key comparison CCQM-K94: 10 μmol/mol dimethyl sulfide in nitrogen
Authors: Lee S , Heo G S , Kim Y , Oh S , Han Q , Wu H , Konopelko L A , Kustikov Y A , Kolobova A V , Efremova O V , Pankratov V V , Pavlov M V , Culleton L P , Brown A S , Brookes C , Li J , Ziel P R , van der Veen A M H 
Published: January 2016

Dimethyl sulfide (DMS) is an important compound in monitoring climate change and is monitored by the World Meteorological Organization Global Atmospheric Watch Volatile Organic Compounds (WMO-GAW VOC) program at several monitoring sites. It is essential that measurement results are accurate and consistent among the assigned values for primary gas mixtures to meet the WMO requirement. The purpose of this comparison is to compare the measurement capability of DMS at approximately 10 μ­mol/mol and expectation to contribute the establishment of traceability to single measurement scale for DMS between NMIs.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Plasma flow, turbulence and magnetic islands in TJ-II
Authors: Estrada T. , Ascasíbar E. , Blanco E. , Cappa A. , Hidalgo C. , Ida K. , López-Fraguas A. , van Milligen B.Ph 
Published: January 2016

Abstract
The effect of magnetic islands on plasma flow and turbulence has been experimentally investigated in ohmically induced magnetic configuration scans at the stellarator TJ-II. This operational mode allows sweeping the radial position of a low order rational surface from the plasma core towards the edge in a controlled way, what reveals effects that are difficult to notice in scans performed on a shot to shot basis. The main diagnostic used in the present work is a two-channel Doppler reflectometer that allows the measurement of the perpendicular rotation velocity of the turbulence and density fluctuations with good spatial and temporal resolution. A characteristic signature of the n/m  =  3/2 magnetic island as it crosses the measurement position is clearly detected: the perpendicular flow reverses at the center of the magnetic island and a flow shear develops at the island boundaries. Fluctuations of the perpendicular flow and density have been also measured along the 3/2 magnetic island. An increase in the low frequency flow oscillations is measured at the magnetic island boundaries together with a reduction in the density fluctuation level; the later being more pronounced at the inner island boundary. These observations could explain the link between magnetic islands and transport barriers observed in a number of fusion devices.
ELM-resolved divertor erosion in the JET ITER-Like Wall
Authors: Den Harder N. , Brezinsek S. , Pütterich T. , Fedorczak N. , Matthews G.F. , Meigs A. , Stamp M.F. , van de Sanden M.C.M. , Van Rooij G.J. 
Published: January 2016

Abstract
Tungsten erosion in H-mode plasmas is quantified in the outer divertor of the JET ITER-Like Wall environment with optical emission spectroscopy on the 400.9 nm atomic neutral tungsten line. A novel cross-calibration procedure is developed to link slow, high spectral resolution spectroscopy and fast photomultiplier tube measurements in order to obtain ELM-resolved photon fluxes. Inter-ELM W erosion is exclusively impurity sputtering by beryllium because of the high sputter threshold for deuterons. Low beryllium concentrations resulted in low inter-ELM sputter yields of around 10−4 with respect to the total flux.
Intra-ELM W sources, which dominate the total W tungsten source, vary independently from the inter-ELM source. The amount of W erosion could only be partly explained by beryllium sputtering, indicating that during ELMs sputtering by fuel species is important. The total W outer divertor source is found to linearly increase with the power crossing the separatrix, whilst excessive divertor fueling can break this trend.
The influence of the W source rate on the tungsten content of the core plasma is investigated using soft x-ray emission to determine the tungsten content. At low source rates the content is determined by the source, but at higher source rates, other phenomena determine the total tungsten content. Indications of impurity flushing by ELMs is seen at ELM frequencies above approximately 40 Hz. The inner/outer divertor asymmetry of the W source during ELMs is investigated, and the outer divertor W source is larger by a factor of

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