bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing the resource requirements of hierarchical scheduling systems
Authors: Kim Jin Hyun , Legay Axel , Traonouez Louis-Marie , Boudjadar Abdeldjalil , Nyman Ulrik , Larsen Kim G. , Lee Insup , Choi Jin-Young 
Published: August 2016

Compositional reasoning on hierarchical scheduling systems is a well-founded formal method that can construct schedulable and optimal system configurations in a compositional way. However, a compositional framework formulates the resource requirement of a component, called an interface, by assuming that a resource is always supplied by the parent components in the most pessimistic way. For this reason, the component interface demands more resources than the amount of resources that are really sufficient to satisfy sub-components. We provide two new supply bound functions which provides tighter bounds on the resource requirements of individual components. The tighter bounds are calculated by using more information about the scheduling system.
We evaluate our new tighter bounds by using a model-based schedulability framework for hierarchical scheduling systems realized as Uppaal models. The timed models are checked using model checking tools Uppaal and Uppaal SMC, and we compare our results with the state of the art tool CARTS.
Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma
Authors: Ciesla Maciej , Marona Paulina , Kozakowska Magdalena , Jez Mateusz , Seczynska Marta , Loboda Agnieszka , Bukowska-Strakova Karolina , Szade Agata , Walawender Magdalena , Kusior Magdalena , Stepniewski Jacek , Szade Krzysztof , Krist Bart , Yagensky Oleksandr , Urbanik Aleksandra , Kazanowska Bernarda , Dulak Jozef , Jozkowicz Alicja 
Published: August 2016

AbstractRhabdomyosarcoma (RMS) is an aggressive soft tissue cancer characterized by disturbed myogenic differentiation. Here we report a role for the oxidative stress response factor HO-1 in progression of RMS. We found that HO-1 was elevated and its effector target miR-206 decreased in RMS cell lines and clinical primary tumors of the more aggressive alveolar phenotype (aRMS). In embryonal RMS (eRMS), HO-1 expression was induced by Pax3/7-FoxO1, an aRMS hallmark oncogene, followed by a drop in miR-206 levels. Inhibition of HO-1 by tin protoporphyrin (SnPP) or siRNA downregulated Pax3/7-FoxO1 target genes and induced a myogenic program in RMS. These effects were not mediated by altered myoD expression; instead, cells with elevated HO-1 produced less reactive oxygen species, resulting in nuclear localization of HDAC4 and miR-206 repression. HO-1 inhibition by SnPP reduced growth and vascularization of RMS tumors in vivo accompanied by induction of miR-206. Effects of SnPP on miR-206 expression and RMS tumor growth were mimicked by pharmacologic inhibition of HDAC. Thus, HO-1 inhibition activates an miR-206–dependent myogenic program in RMS, offering a novel therapeutic strategy for treatment of this malignancy. Cancer Res; 76(19); 5707–18. ©2016 AACR.
Amplification of TLK2 Induces Genomic Instability via Impairing the G2–M Checkpoint
Authors: Kim Jin-Ah , Anurag Meenakshi , Veeraraghavan Jamunarani , Schiff Rachel , Li Kaiyi , Wang Xiao-Song 
Published: August 2016

Abstract
Managing aggressive breast cancers with enhanced chromosomal instability (CIN) is a significant challenge in clinics. Previously, we described that a cell cycle–associated kinase called Tousled-like kinase 2 (TLK2) is frequently deregulated by genomic amplifications in aggressive estrogen receptor–positive (ER+) breast cancers. In this study, it was discovered that TLK2 amplification and overexpression mechanistically impair Chk1/2-induced DNA damage checkpoint signaling, leading to a G2–M checkpoint defect, delayed DNA repair process, and increased CIN. In addition, TLK2 overexpression modestly sensitizes breast cancer cells to DNA-damaging agents, such as irradiation or doxorubicin. To our knowledge, this is the first report linking TLK2 function to CIN, in contrast to the function of its paralog TLK1 as a guardian of genome stability. This finding yields new insight into the deregulated DNA damage pathway and increased genomic instability in aggressive ER+ breast cancers.
Implications: Targeting TLK2 presents an attractive therapeutic strategy for the TLK2-amplified breast cancers that possess enhanced genomic instability and aggressiveness. Mol Cancer Res; 14(10); 920–7. ©2016 AACR.
Role of monocytes and endothelial cells in heparin-induced thrombocytopenia
Authors: Madeeva Daria , Cines Douglas B. , Poncz Mortimer , Rauova Lubica 
Published: August 2016

SummaryHeparin-induced thrombocytopenia (HIT) is an autoimmune disorder characterised by thrombocytopenia and thrombosis. The mechanisms leading to platelet destruction are complex and the thrombotic complications of HIT appear to be due to multiple different intravascular targets. The dual binding of HIT antibodies to platelet surface PF4/GAG complexes and to FcγRIIA likely leads to both platelet clearance and to their direct activation. Monocytes and endothelial cells bind PF4 with higher avidity than platelets and are more resistant to competitive removal of surface-bound PF4 in the presence of heparin. Binding of HIT antibodies to PF4/glycosaminoglycan complexes on the surface on these cells leads to their activation and increased procoagulant activity. Binding of higher levels of PF4 released from activated platelets to the endothelium may lead to changes of the anticoagulant properties of the glycocalyx and target the endothelial cells for HIT antibodies. Pathogenic antibodies bound to endothelial cells further promote prothrombotic conditions by a mechanism that is independent of FcγR activation, yet not completely understood. A more detailed understanding of the role of monocytes and endothelium may identify new targets for intervention to mitigate the risk of thrombosis with less impact on systemic haemostasis than current approaches to treatment for this serious disorder.
Connexins in endothelial barrier function – novel therapeutic targets countering vascular hyperpermeability
Authors: Soon Allyson Shook , Chua Jia , Becker David 
Published: August 2016

SummaryProlonged vascular hyperpermeability is a common feature of many diseases. Vascular hyperpermeability is typically associated with changes in the expression patterns of adherens and tight junction proteins. Here, we focus on the less-appreciated contribution of gap junction proteins (connexins) to basal vascular permeability and endothelial dysfunction. First, we assess the association of connexins with endothelial barrier integrity by introducing tools used in connexin biology and relating the findings to customary readouts in vascular biology. Second, we explore potential mechanistic ties between connexins and junction regulation. Third, we review the role of connexins in microvascular organisation and development, focusing on interactions of the endothelium with mural cells and tissue-specific perivascular cells. Last, we see how connexins contribute to the interactions between the endothelium and components of the immune system, by using neutrophils as an example. Mounting evidence of crosstalk between connexins and other junction proteins suggests that we rethink the way in which different junction components contribute to endothelial barrier function. Given the multiple points of connexin-mediated communication arising from the endothelium, there is great potential for synergism between connexin-targeted inhibitors and existing immune-targeted therapeutics. As more drugs targeting connexins progress through clinical trials, it is hoped that some might prove effective at countering vascular hyperpermeability.
Diabetes Mellitus and Outcomes of Cardiac Resynchronization With Implantable Cardioverter-Defibrillator Therapy in Older Patients With Heart Failure
Authors: Echouffo-Tcheugui Justin B. , Masoudi Frederick A. , Bao Haikun , Spatz Erica S. , Fonarow Gregg C. 
Published: August 2016

Background—
Large-scale data on outcomes with cardiac resynchronization therapy with defibrillator in patients with diabetes mellitus are limited. We compared outcomes after cardiac resynchronization therapy with defibrillator implantation among patients with heart failure who have diabetes mellitus versus those without diabetes mellitus.

Methods and Results—

Survival curves and covariate adjusted hazard ratio (HR) or odds ratio were used to assess the risks for death, readmission, and device-related complications by diabetes mellitus status among 18 428 patients at least 65 years old receiving cardiac resynchronization therapy with defibrillator from the National Cardiovascular Data Registry, implantable cardioverter-defibrillator registry between 2006 and 2009, with up to 3 years of follow-up. Accounting for differences between groups, compared with those without diabetes mellitus (n=11 345), patients with diabetes mellitus (n=7083) had a higher risk of death both at 1 year (HR, 1.16 [95% confidence interval (CI), 1.05–1.29];
P
=0.0037) and 3 years (HR, 1.21 [1.14–1.29];
P
<0.001) after device implantation and higher risks of all-cause readmission (sub-HR, 1.16 [1.11–1.21] at 1 year;
P
<0.0001; sub-HR, 1.15 [1.11–1.19] at 3 years;
P
<0.0001) and heart failure–related readmission (sub-HR, 1.18 [1.09–1.28] at 1 year;
P
<0.0001; and sub-HR, 1.22 [1.15–1.30] at 3 years;
P
<0.0001). Device-related complications within 90 days did not differ between those with and without diabetes mellitus (odds ratio: 0.90 [0.77–1.06];
P
=0.37). Interactions of age, sex, ischemic cardiomyopathy, renal failure, or QRS duration were not significant.

Conclusions—
In older patients with heart failure receiving cardiac resynchronization therapy with defibrillator, diabetes mellitus was independently associated with greater risks of death and rehospitalization, but similar risks of procedural complications.
The Impact of Horizontal Resolution on North American Monsoon Gulf of California Moisture Surges in a Suite of Coupled Global Climate Models
Authors: Pascale Salvatore , Bordoni Simona , Kapnick Sarah B. , Vecchi Gabriel A. , Jia Liwei , Delworth Thomas L. , Underwood Seth , Anderson Whit 
Published: August 2016

Abstract
The impact of atmosphere and ocean horizontal resolution on the climatology of North American monsoon Gulf of California (GoC) moisture surges is examined in a suite of global circulation models (CM2.1, FLOR, CM2.5, CM2.6, and HiFLOR) developed at the Geophysical Fluid Dynamics Laboratory (GFDL). These models feature essentially the same physical parameterizations but differ in horizontal resolution in either the atmosphere (≃200, 50, and 25 km) or the ocean (≃1°, 0.25°, and 0.1°). Increasing horizontal atmospheric resolution from 200 to 50 km results in a drastic improvement in the model’s capability of accurately simulating surge events. The climatological near-surface flow and moisture and precipitation anomalies associated with GoC surges are overall satisfactorily simulated in all higher-resolution models. The number of surge events agrees well with reanalyses, but models tend to underestimate July–August surge-related precipitation and overestimate September surge-related rainfall in the southwestern United States. Large-scale controls supporting the development of GoC surges, such as tropical easterly waves (TEWs), tropical cyclones (TCs), and trans-Pacific Rossby wave trains (RWTs), are also well captured, although models tend to underestimate the TEW and TC magnitude and number. Near-surface GoC surge features and their large-scale forcings (TEWs, TCs, and RWTs) do not appear to be substantially affected by a finer representation of the GoC at higher ocean resolution. However, the substantial reduction of the eastern Pacific warm sea surface temperature bias through flux adjustment in the Forecast-Oriented Low Ocean Resolution (FLOR) model leads to an overall improvement of tropical–extratropical controls on GoC moisture surges and the seasonal cycle of precipitation in the southwestern United States.
A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia
Authors: Lichtenstein Daniel A. , Crispin Andrew W. , Sendamarai Anoop K. , Campagna Dean R. , Schmitz-Abe Klaus , Sousa Cristovao M. , Kafina Martin D. , Schmidt Paul J. , Niemeyer Charlotte M. , Porter John , May Alison , Patnaik Mrinal M. , Heeney Matthew M. , Kimmelman Alec , Bottomley Sylvia S. , Paw Barry H. , Markianos Kyriacos , Fleming Mark D. 
Published: August 2016

Key Points
A recurring mutation in NDUFB11 causes congenital sideroblastic anemia. The NDUFB11 p.93del mutation impairs erythroid proliferation, but not differentiation.
The multifunctional roles of vegetated strips around and within agricultural fields. A systematic map protocol
Authors: Haddaway Neal Robert , Brown Colin , Eggers Sönke , Josefsson Jonas , Kronvang Brian , Randall Nicola , Uusi-Kämppä Jaana 
Published: August 2016

Abstract
Background
Agriculture and agricultural intensification can have significant negative impacts on the environment, including nutrient and pesticide leaching, spreading of pathogens, soil erosion and reduction of ecosystem services provided by terrestrial and aquatic biodiversity. The establishment and management of vegetated strips adjacent to farmed fields (including various field margins, buffer strips and hedgerows) are key mitigation measures for these negative environmental impacts and environmental managers and other stakeholders must often make decisions about how best to design and implement vegetated strips for a variety of different outcomes. However, it may be difficult to obtain relevant, accurate and summarised information on the effects of implementation and management of vegetated strips, even though a vast body of evidence exists on multipurpose vegetated strip interventions within and around fields. To improve the situation, we describe a method for assembling a database of relevant research relating to vegetated strips undertaken in boreo-temperate farming systems (arable, pasture, horticulture, orchards and viticulture), according to the primary question: What evidence exists regarding the effects of field margins on nutrients, pollutants, socioeconomics, biodiversity, and soil retention?

Methods
We will search 13 bibliographic databases, one search engine and 37 websites for stakeholder organisations using a predefined and tested search string that focuses on a comprehensive list of vegetated strip synonyms. Non-English language searches in Danish, Finnish, German, Spanish, and Swedish will also be undertaken using a web-based search engine. We will screen search results at title, abstract and full text levels, recording the number of studies deemed non-relevant (with reasons at full text). A systematic map database that displays the meta-data (i.e. descriptive summary information about settings and methods) of relevant studies will be produced following full text assessment. The systematic map database will be displayed as a web-based geographical information system (GIS). The nature and extent of the evidence base will be discussed.
Persistent nuclear actin filaments inhibit transcription by RNA polymerase II
Authors: Serebryannyy Leonid A. , Parilla Megan , Annibale Paolo , Cruz Christina M. , Laster Kyle , Gratton Enrico , Kudryashov Dmitri , Kosak Steven T. , Gottardi Cara J. , de Lanerolle Primal 
Published: August 2016

ABSTRACT
Actin is abundant in the nucleus and it is clear that nuclear actin has important functions. However, mystery surrounds the absence of classical actin filaments in the nucleus. To address this question, we investigated how polymerizing nuclear actin into persistent nuclear actin filaments affected transcription by RNA polymerase II. Nuclear filaments impaired nuclear actin dynamics by polymerizing and sequestering nuclear actin. Polymerizing actin into stable nuclear filaments disrupted the interaction of actin with RNA polymerase II and correlated with impaired RNA polymerase II localization, dynamics, gene recruitment, and reduced global transcription and cell proliferation. Polymerizing and crosslinking nuclear actin in vitro similarly disrupted the actin–RNA-polymerase-II interaction and inhibited transcription. These data rationalize the general absence of stable actin filaments in mammalian somatic nuclei. They also suggest a dynamic pool of nuclear actin is required for the proper localization and activity of RNA polymerase II.
Social Sphere and Its Capacity Building at the Present Stage
Authors: Чубриков  , Chubrikov N. 
Published: August 2016

The author considers the social sphere (education, health, culture, etc.) as a
complex system formation, the activity of which is related to the satisfaction of
spiritual and material needs of people to high-quality reproduction of the human
potential and human resources. The article shows the close interrelation and
interdependence of social infrastructure and material production. Institutional
development in the dynamics of this important area of social life is characterized.
Young Women's Contraceptive Decision Making: Do Preferences for Contraceptive Attributes Align with Method Choice?
Authors: Marshall Cassondra , Guendelman Sylvia , Mauldon Jane , Nuru‐Jeter Amani 
Published: August 2016

ABSTRACTCONTEXTUnderstanding how women's preferences for certain attributes of contraceptive methods relate to their method choice can inform the content of contraceptive counseling.METHODSData from 715 women aged 18–29 who had ever used contraceptives were drawn from the 2009 National Survey of Reproductive and Contraceptive Knowledge. Chi‐square tests and multivariable logistic regression analyses were used to examine how women's preferences for specific contraceptive attributes were related to their social and demographic characteristics and their current contraceptive choice.RESULTSThe majority of women considered it extremely important for a method to be very effective at preventing pregnancy (79%) and to be effective at preventing HIV and STDs (67%); fewer than one‐quarter felt similarly about a method's being hormone‐free (22%). Women who felt it was quite or extremely important for a method to be very effective at preventing pregnancy were not more likely to use the most effective methods than were women who considered this attribute not at all or only slightly important. Women who considered it quite or extremely important for a method to be hormone‐free were less likely than others to use hormonal methods (odds ratio, 0.4), and women who considered STD protection quite or extremely important had elevated odds of relying on condoms alone, rather than on an effective contraceptive method alone (3.6).CONCLUSIONSMost women desire a very effective method for pregnancy prevention, but it is unclear how this translates to their contraceptive use. The associations between women's preferred contraceptive attributes and method choice warrant further attention.
Descrição alimentar e estágio de maturação de Crassostrea brasiliana comercializadas no mercado municipal de Paranaguá, Paraná, Brasil
Authors: Christo Susete Wambier , Ivachuk Celene Silva , Veroneze Franccielli , Ferreira Jr Augusto Luiz , Absher Theresinha Monteiro 
Published: August 2016

Crasssotrea brasiliana (Lamark, 1819) is an epibiont filter feeder bivalve of fast growth and fast gonadal restructuring that feeds by filtration of microalgae, these characteristics are mainly related to the amount and quality of the phytoplankton filtered by the animal. In Paraná coast several sites of cultivation of the species can be found in Paranaguá Estuarine Complex (PEC) and Guaratuba Bay. Therefore, this work had as objectives to evaluate the size and the phytoplankton species ingested by adults of the oyster C. brasiliana and to describe its reproductive characteristics (index of meat revenue and stages of gonadal maturation). Oysters were acquired monthly in the Municipal Market of Paranaguá from cultivation in the PEC. The oysters were measured and length values (L), height (H) and gross weight (GW) obtained. Gonadal maturation stages were evaluated through the macroscopic examination of the gonads and revenue (R) through the wet weight of meat. The digestive gland was removed for the microscopic analysis of the stomach content (identification and measurement of the phytoplankton). The highest value of the R average (12,79%) was in July 2007, when a great portion of the population presented full gonads, however the predominance of individuals with full gonads (partially full and full) occurred in periods of warmer waters. The main microalgae genera found were: Diatoms - Gyrosigma Hassall, 1845; Cyclotella (Kützing) Brébisson, 1838; Coscinodiscus Ratray, 1890 and Pleurosigma W. Smith, 1852; Dinoflagellates - Noctiluca Suriray, 1836 and Ceratium Schrank, 1793 with size of phytoplankton ingested varying from 5 to 260 µm.
Relationship between serum cystatin-C and urinary neutrophil gelatinase-associated lipocalin in septic children
Authors: Mandei Jose , Iskandar Elisa , Umboh Adrian , Lestari Hesti 
Published: August 2016

Background Sepsis may lead to acute kidney injury (AKI)in patients treated in pediatric intensive care units (PICU).Currently, serum creatinine is used as a biomarker for thediagnosis of AKI. However, it is not a sensitive nor specifictest for AKI. The scarcity of biomarkers leads to delays in thediagnosis and treatment of AKI. Serum cystatin-C (sCys-C)and urinary neutrophil gelatinase-associated lipocalin (uNGAL)are potential biomarkers that look promising for early diagnosisof AKI.Objective To identify the relation of cystatin-C and NGAL inchildren with sepsis.Methods Serum cystatin-C and uNGAL were measured onseptic patients aged one month to 12 years. The diagnosesof sepsis were based on the 2002 International Pediatric SepsisConcensus. Patients were admitted to the Pediatric IntensiveDepartment of the Prof. Dr. R. D. Kandou Hospital, Manadofrom January to June 2013. The exclusion criteria werepatients with trauma, burns, severe dehydration, malnutrition,obesity, and history of renal diseases. Data analyses includeddescriptions for the characteristic data and Pearson’s coefficientcorrelation. A P value of 0.05 was considered to be statisticallysignificant. Data were analyzed with SPSS software for Windowsversion 21.Results Thirty-eight patients met the inclusion criteria, of whom23 were male and 15 were female. Their mean age was 22.6 (SD32.24) months, with overweight in 2 children, good nutrition in25 children, and under nutrition in 11 children. An increasedlevel of sCys-C was found in 22 children and an increased levelof uNGAL was found in 19 children. Serum cystatin-C wassignificantly correlated to uNGAL in septic patients (r=0.614;P<0.01).Conclusion There is a positively correlated relationship betweensCys C and uNGAL in septic children. Increased sCys C is associated with increased uNGAL in septic children.