bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: General Cycloaddition Between a Trimethylsilyl‐Capped Alkyne and an Azide Catalyzed by an N‐Heterocyclic Carbene‐Copper Complex and Pyridine‐Biscarboxamide.
Authors: Xu Haochen , Sun Zhihua 
Published: September 2016

AbstractThe title reaction is applied to a variety of Tms‐capped substrates (I), with electron‐rich alkynes generally giving higher yields and nitroaromatic alkynes giving lower yields.
ChemInform Abstract: Synthesis of 2‐Indolyltetrahydroquinolines by Zinc(II)‐Catalyzed Intramolecular Hydroarylation‐Redox Cross‐Dehydrogenative Coupling of N‐Propargylanilines with Indoles.
Authors: Li Guangzhe , Nakamura Hiroyuki 
Published: September 2016

AbstractThis intramolecular hydroarylation‐redox cross‐dehydrogenative coupling of propargylic anilines with indoles proceeds in the presence of zinc(II) catalysts to give 2‐indolyltetrahydroquinolines in good to high yields.
ChemInform Abstract: Palladium/L‐Proline‐Catalyzed Enantioselective α‐Arylative Desymmetrization of Cyclohexanones.
Authors: Liu Ren‐Rong , Li Bao‐Le , Lu Jun , Shen Chong , Gao Jian‐Rong , Jia Yi‐Xia 
Published: September 2016

AbstractFollowing a scalable procedure, a series of morphan derivatives is produced in very high yields and with very high enantioselectivities.
ChemInform Abstract: A Short and Efficient Approach to Pyrrolo[2,1‐a]isoquinoline and Pyrrolo[2,1‐a]benzazepine Derivatives.
Authors: Jebali Khaoula , Planchat Aurelien , Amri Hassen , Mathe‐Allainmat Monique , Lebreton Jacques 
Published: September 2016

AbstractThe title products are prepared following an efficient two‐step reaction sequence including an intramolecular Friedel‐Crafts cyclization of β‐benzoyl/acetyl‐substituted pyrrol‐2(5H)‐ones tethered via nitrogen to an electron‐rich arene.
ChemInform Abstract: Synthesis of 2‐Aryl‐2,3‐dihydro‐1,8‐naphthyridin‐4(1H)‐ones by Deprotective Cyclization of N‐{3‐[(2E)‐3‐Arylprop‐2‐enoyl]pyridin‐2‐yl}‐2,2‐dimethylpropanamides in Water.
Authors: Kobayashi Kazuhiro , Kosuna Risa , Imaoka Ayumi 
Published: September 2016

AbstractTitle compounds are synthesized in a three‐step reaction sequence.
ChemInform Abstract: Silver‐Catalyzed Direct C(sp2)—H Phosphorylation of Indoles Leading to Phosphoindoles.
Authors: Sun Wang‐Bin , Xue Jian‐Fei , Zhang Guo‐Yu , Zeng Run‐Sheng , An Li‐Tao , Zhang Pei‐Zhi , Zou Jian‐Ping 
Published: September 2016

AbstractPhosphonoindoles are regioselectively obtained in moderate to good yields by a radical process.
ChemInform Abstract: 1,3,2‐Diazaphospholidine (N‐Heterocyclic Phosphine)‐Mediated Carbon—Phosphorus Bond‐Forming, One‐Pot Tandem Reaction: A Route to α‐Amino Phosphonates.
Authors: Mulla Karimulla , Kang Jun Yong 
Published: September 2016

AbstractFor the construction of an N—C—P bond unit, a 1,3,2‐diazaphospholidine (N‐heterocyclic phosphine)—thiourea‐mediated phospha‐Mannich/intramolecular nucleophilic substitution reaction is developed.
ChemInform Abstract: A New Heterocycle: Furo[3,2‐c]isoselenazole.
Authors: Bardasov Ivan N. , Mikhailov Denis L. , Alekseeva Anastasiya U. , Ershov Oleg V. , Tafeenko Viktor A. 
Published: September 2016

AbstractPreviously undescribed isoselenazoles (II) are obtained by a simple domino process in one synthetic operation from malononitriles (I) with potassium selenocyanate.
ChemInform Abstract: Withanolides Derived from Physalis peruviana (Poha) with Potential Antiinflammatory Activity.
Authors: Chang Leng Chee , et al.  
Published: September 2016

AbstractThree new withanolides, physaperuvin G (I), I (II) and J (III), are isolated together with seven known compounds from the aerial parts of Physalis peruviana.
ChemInform Abstract: Hafnium(IV) Triflate as a Highly Efficient Catalyst for Ferrier Rearrangement of O‐ and S‐Nucleophiles with Glycals.
Authors: Liu Yonghui , Song Tianbang , Meng Weijia , Xu Yun , Wang Peng George , Zhao Wei 
Published: September 2016

Abstract2,3‐Unsaturated O‐ and S‐glycosides are obtained by stereoselective glycosylation of glucal (I).
ChemInform Abstract: Liquid‐Phase Synthesis of Ba2V2O7 Phosphor Powders and Films Using Immiscible Biphasic Organic—Aqueous Systems.
Authors: Takahashi Mami , Hagiwara Manabu , Fujihara Shinobu 
Published: September 2016

AbstractBoth powders and films of the title phosphor are synthesized using a biphasic organic—aqueous system consisting of an aqueous solution of Ba(OAc)2 and a solution of VO(OEt)3 in xylene (80 °C, 24 h).
Entwicklung eines optisch zugänglichen Reaktors zur Thermographiemessung in einer Katalysatorschüttung
Authors: Schüler Christian , Hinrichsen Olaf 
Published: September 2016

AbstractUm die intrinsische Kinetik bei heterogen‐katalysierten stark exothermen Gasphasenreaktionen messen zu können, sollten sowohl Stoff‐ als auch Wärmetransportlimitierungen vermieden werden. Auch eine Ungleichverteilung der Temperatur im Katalysatorbett, wie sie durch Hotspots verursacht wird, wirkt sich verfälschend auf diese Ergebnisse aus. Eine vielversprechende Technik zur kontaktlosen Temperaturmessung ist die Thermographie. Im Rahmen dieser Arbeit wurde diese Technik verwendet, um die Temperaturentwicklung und ‐verteilung während der stark exothermen CO2‐Methanisierung in Abhängigkeit der Bett‐ und Feedgasverdünnung sowie der Katalysatorbelastung zu untersuchen.
Prostate cancer screening: Do guidelines matter?
Authors: Kearns James T. , Gore John L. 
Published: September 2016

The prostate‐specific antigen practices reported by Hutchinson et al in this issue of Cancer may reflect an isolated persistence of prostate‐specific antigen ordering behaviors in a local health system due to other broader reports. However, it also raises an important issue: what is the appropriate level of screening and referral? Could continued but more thoughtful prostate‐specific antigen screening and urology referral lead to better health outcomes among men with prostate cancer?See also pages 3785‐93.
Persistence of minimal residual disease assessed by multiparameter flow cytometry is highly prognostic in younger patients with acute myeloid leukemia
Authors: Ravandi Farhad , Jorgensen Jeffrey , Borthakur Gautam , Jabbour Elias , Kadia Tapan , Pierce Sherry , Brandt Mark , Wang Sa , Konoplev Sergej , Wang Xuemei , Huang Xuelin , Daver Naval , DiNardo Courtney , Andreeff Michael , Konopleva Marina , Estrov Zeev , Garcia‐Manero Guillermo , Cortes Jorge , Kantarjian Hagop 
Published: September 2016

BACKGROUNDPredicting outcomes for patients with acute myeloid leukemia (AML) on the basis of pretreatment predictors has been the cornerstone of management. Posttreatment prognostic factors are increasingly being evaluated.METHODSAmong 280 younger patients who were treated with intermediate‐dose cytarabine (total ≥ 5 g/m2) and idarubicin‐based induction chemotherapy and achieved remission, 186 were assessed for minimal residual disease (MRD) with an 8‐color multiparameter flow cytometry panel performed on bone marrow specimens with a sensitivity of 0.1% or higher.RESULTSOne hundred sixty‐six patients had samples available 1 to 2 months after induction at the time of complete remission (CR), and 79% became negative for MRD, with an MRD‐negative status associated with an improvement in relapse‐free survival (RFS;P = .0002) and overall survival (OS;P = .0002). One hundred sixteen were evaluated for their MRD status during consolidation, and 86% were negative, with an MRD‐negative status associated with a significant improvement in RFS (P < .0001) and OS (P < .0001). Sixty‐nine patients were evaluated for their MRD status after completion of all therapy, and 84% were negative, with an MRD‐negative status associated with an improvement in RFS (P < .0001) and OS (P < .0001). In a multivariate analysis including age, cytogenetics, response (CR vs CR with incomplete platelet recovery/incomplete blood count recovery), and MRD, achieving an MRD‐negative status was the most important independent predictor of RFS and OS at response (P = .008 andP = .0008, respectively), during consolidation (P < .0001 for both), and at the completion of therapy (P < .0001 andP = .002, respectively).CONCLUSIONSAchieving an MRD‐negative status according to multiparameter flow cytometry is associated with a highly significant improvement in the outcomes of younger patients with AML receiving cytosine arabinoside plus idarubicin‐based induction and consolidation regimens.Cancer2017;123:426–435.©2016 American Cancer Society.
Platelet Aggregation Inhibitory Effects and Pharmacokinetics of Prasugrel Used in Combination With Aspirin in Healthy Japanese Subjects
Authors: Umemura Kazuo , Ikeda Yasuhiko , Matsushima Nobuko , Kondo Kazunao 
Published: September 2016

AbstractWe evaluated the pharmacokinetics and pharmacodynamics of prasugrel used in combination with aspirin in healthy Japanese subjects. All subjects received aspirin 100 mg/day. Subsequently, in the single‐administration study, 23 subjects also received prasugrel 20 or 30 mg, and in the multiple‐administration study, 20 subjects received a loading dose of prasugrel 20 or 30 mg on day 1, followed by a maintenance dose of prasugrel 5 or 7.5 mg/day, respectively, on days 2–5. In both studies, the plasma concentration of the active metabolite of prasugrel, R‐138727, reached a maximum 0.5 hours after administration and rapidly decreased within 4 hours. In the single‐administration study, the inhibitory effect on adenosine diphosphate–induced platelet aggregation was significantly higher in the prasugrel 20‐ and 30‐mg groups than in the placebo group at all times (1–144 hours) after administration. In the multiple‐administration study, a similar antiplatelet effect was found after both the loading dose and the maintenance dose and was maintained for 3–6 days after the last administration. There were study drug‐related adverse events; however, all were mild, and none was clinically significant.
Beneficial Role of Reduced Graphene Oxide for Electron Extraction in Highly Efficient Perovskite Solar Cells
Authors: Cho Kyung Taek , Grancini Giulia , Lee Yonghui , Konios Dimitrios , Paek Sanghyun , Kymakis Emmanuel , Nazeeruddin Mohammad Khaja 
Published: September 2016

AbstractIn this work we systematically investigated the role of reduced graphene oxide (rGO) in hybrid perovskite solar cells (PSCs). By mixing rGO within the mesoporous TiO2 (m‐TiO2) matrix, highly efficient solar cells with power conversion efficiency values up to 19.54 % were realized. In addition, the boosted beneficial role of rGO with and without Li‐treated m‐TiO2 is highlighted, improving transport and injection of photoexcited electrons. This combined system may pave the way for further development and optimization of electron transport and collection in high efficiency PSCs.
Comparing tree‐ring and permanent plot estimates of aboveground net primary production in three eastern U.S. forests
Authors: Dye Alex , Barker Plotkin Audrey , Bishop Daniel , Pederson Neil , Poulter Benjamin , Hessl Amy 
Published: September 2016

AbstractForests account for a large portion of sequestered carbon, much of which is stored as wood in trees. The rate of carbon accumulation in aboveground plant material, or aboveground net primary productivity (aNPP), quantifies annual to decadal variations in forest carbon sequestration. Permanent plots are often used to estimate aNPP but are usually not annually resolved and take many years to develop a long data set. Tree rings are a unique and infrequently used source for measuring aNPP, and benefit from fine spatial (individual trees) and temporal (annual) resolution. Because of this precision, tree rings are complementary to permanent plots and the suite of tools used to study forest productivity. Here we evaluate whether annual estimates of aNPP developed from tree rings approximate estimates derived from colocated permanent plots. We studied a lowland evergreen (Howland, Maine), mixed deciduous (Harvard Forest, Massachusetts), and mixed mesophytic (Fernow, West Virginia) forest in the eastern United States. Permanent plots at the sites cover an area of 2–3 ha, and we use these areas as benchmarks indicative of the forest stand. We simulate random draws of permanent plot subsets to describe the distribution of aNPP estimates given a sampling area size equivalent to the tree‐ring plots. Though mean tree‐ring aNPP underestimates permanent plot aNPP slightly at Howland and Fernow and overestimates at Harvard Forest when compared with the entire permanent plot, it is within the 95% confidence interval of the random draws of equal‐sized sampling area at all sites. To investigate whether tree‐ring aNPP can be upscaled to the stand, we conducted a second random draw of permanent plot subsets simulating a twofold increase in sampling area. aNPP estimates from this distribution were not significantly different from results of the initial sampling area, though variance decreased as sampling area approaches stand area. Despite several concerns to consider when using tree rings to reconstruct aNPP (e.g., upscaling, allometric, and sampling uncertainties), the benefits are apparent, and we call for the continued application of tree rings in carbon cycle studies across a broader range of species diversity, productivity, and disturbance histories to fully develop this potential.
Ploidy level in the genus Leucanthemum correlates with resistance to a specialist herbivore
Authors: Stutz Sonja , Hinz Hariet L. , Konowalik Kamil , Müller‐Schärer Heinz , Oberprieler Christoph , Schaffner Urs 
Published: September 2016

AbstractPolyploidy is considered to be a major source of genetic diversity in plants. Genome duplication has been shown repeatedly to be associated with changes in biotic interactions, but little is known about whether species traits such as herbivore resistance consistently change with increasing ploidy level among closely related plant species. We tested whether larval survival and performance of the specialist root‐mining moth Dichrorampha aeratana are influenced by the ploidy level of plant species in the genus Leucanthemum by experimentally infesting 16 different taxa with ploidy levels ranging from diploid to dodecaploid. We found that survival of D. aeratana larvae consistently decreased with increasing ploidy level, irrespective of whether phylogenetic distance among taxa was taken into account or not. The mass of larvae and the proportion of adults emerging from last‐instar larvae, however, did not consistently change with increasing ploidy level. Root biomass and dry matter content of the Leucanthemum taxa were neither correlated with ploidy level nor correlated with survival or mass of D. aeratana larvae. In summary, our results provide evidence that in the genus Leucanthemum, resistance to the specialist root herbivore D. aeratana consistently increases with increasing plant ploidy level, but it remains unclear which characteristics associated with polyploidy account for the higher herbivore resistance.
Direct intralesional ethanol sclerotherapy of extensive venous malformations with oropharyngeal involvement after a temporary tracheotomy in the head and neck: Initial results
Authors: Wang Deming , Su Lixin , Han Yifeng , Wang Zhenfeng , Zheng Lianzhou , Li Jichen , Fan Xindong 
Published: September 2016

AbstractBackgroundThe purpose of this study was to evaluate the safety and efficacy of direct intralesional ethanol sclerotherapy for venous malformations (VMs) with oropharyngeal involvement after a temporary tracheotomy.MethodsA retrospective assessment was carried out to evaluate the efficacy of direct intralesional ethanol sclerotherapy on 21 consecutive patients presenting with extensive VMs involving the oropharynx in the head and neck and who had undergone tracheotomy.ResultsOf the 21 patients, 4 were treated once and 17 were treated from 2 to 5 times. The duration of follow‐up was, on average, 9.1 months. Of the 21 patients, 7 (33.3%) had complete palliation, whereas the rest (66.7%) achieved partial palliation. Minor complications occurred in 12 of the 21 patients.ConclusionDirect intralesional ethanol sclerotherapy after a temporary tracheotomy is a safe and effective treatment for extensive VMs involving oropharyngeal areas of the head and neck. © 2016 Wiley Periodicals, Inc. Head Neck 39: 288–296, 2017
Proposed homology of the dorsomedial subdivision and V‐shaped layer of the avian hippocampus to Ammon's horn and dentate gyrus, respectively
Authors: Atoji Yasuro , Sarkar Sonjoy , Wild J. Martin 
Published: September 2016

ABSTRACTThe avian hippocampal formation differs considerably from that of mammals both in terms of position and cytoarchitecture. On the basis of fiber connections in pigeons, however, we previously proposed that the dorsomedial subdivision (DM) and the V‐shaped layer of the hippocampal formation correspond to Ammon's horn and the dentate gyrus of mammals, respectively. In the present study, we provide evidence in support of this hypothesis by double staining hippocampal neurons using tract‐tracing and gene expression. After cholera toxin subunit B (CTB) was injected into the lateral septal nucleus (SL), and vesicular glutamate transporter 2 (vGluT2) mRNA, a gene marker for glutamatergic neurons, was visualized in the same retrogradely labeled neurons with in situ hybridization, most CTB+/vGluT2+ neurons were concentrated in DM, but were rare in the V‐shaped layer. The distribution pattern of CTB+/vGluT2+ neurons in the hippocampal formation did not change when CTB injection sites were shifted in a rostrocaudal direction in SL. SL expresses a variety of mRNAs for ionotropic glutamate receptor subunits (GluA1, GluA2, GluK2, GluK4, and GluN1). The findings indicate that DM neurons provide descending glutamatergic axons to SL. Additionally, the present study showed that Prox1 mRNA, a gene marker for the dentate gyrus in mammals, was intensely expressed in the V‐shaped layer in the pigeon hippocampus. Together these results strengthen our original hypothesis that DM and the V‐shaped layer in the pigeon hippocampus are homologous to Ammon's Horn and the dentate gyrus, respectively. © 2016 Wiley Periodicals, Inc.
Relation between ultrasonic properties, rheology and baking quality for bread doughs of widely differing formulation
Authors: Peressini Donatella , Braunstein Dobrila , Page John H , Strybulevych Anatoliy , Lagazio Corrado , Scanlon Martin G 
Published: September 2016

AbstractBACKGROUNDThe objective was to evaluate whether an ultrasonic reflectance technique has predictive capacity for breadmaking performance of doughs made under a wide range of formulation conditions. Two flours of contrasting dough strength augmented with different levels of ingredients (inulin, oil, emulsifier or salt) were used to produce different bread doughs with a wide range of properties. Breadmaking performance was evaluated by conventional large‐strain rheological tests on the dough and by assessment of loaf quality. The ultrasound tests were performed with a broadband reflectance technique in the frequency range of 0.3–6 MHz.RESULTSPrincipal component analysis showed that ultrasonic attenuation and phase velocity at frequencies between 0.3 and 3 MHz are good predictors for rheological and bread scoring characteristics.CONCLUSIONSUltrasonic parameters had predictive capacity for breadmaking performance for a wide range of dough formulations. Lower frequency attenuation coefficients correlated well with conventional quality indices of both the dough and the bread. © 2016 Society of Chemical Industry
Phenylboronic Acid‐Cross‐Linked Nanoparticles with Improved Stability as Dual Acid‐Responsive Drug Carriers
Authors: Wang Chunran , Wang Jinze , Chen Xiaofei , Zheng Xu , Xie Zhigang , Chen Li , Chen Xuesi 
Published: September 2016

Herein, a kind of dual acid‐sensitive nanoparticles based on monomethoxy poly(ethylene glycol)‐imine‐β‐cyclodextrin is constructed by a facile phenylboronic acid‐cross‐linked way. The data of dynamic light scattering and transmission electron microscope reveal the cross‐linked nanoparticles have improved stability. The cross‐linked nanoparticles could easily self‐assemble and load the anticancer drug at neutral pH condition. However, when the drug‐loaded nanoparticles are delivered to extracellular tumor sites (pH ≈6.8), the surface of the nanoparticles would be amino positively charged and easily internalized by tumor cell due to the cleavage of the acid‐labile benzoic–imine. Subsequently, with the acidity in subcellular compartments significantly increasing (such as the endosome pH ≈5.3), the loaded drug would fast release from the endocytosis carriers due to the hydrolysis of boronate ester. These features suggest that these dual acid‐sensitive cross‐linked nanoparticles not only possess excellent biocompatibility but also can efficiently load and deliver anticancer drug into tumor cells to enhance the inhibition of cellular proliferation, outlining a favorable platform as drug carriers.
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Progressive Brain Atrophy in Alternating Hemiplegia of Childhood
Authors: Sasaki Masayuki , Ishii Atsushi , Saito Yoshiaki , Hirose Shinichi 
Published: September 2016

AbstractBackgroundAlternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disorder that includes involuntary movements, paroxysmal symptoms, and various severities of nonparoxysmal symptoms.ObjectiveTo investigate the occurrence of structural brain abnormalities in patients with AHC during clinical courses.MethodsConventional brain magnetic resonance imaging findings and clinical courses were retrospectively investigated in 14 patients with AHC confirmed by ATP1A3 mutations.ResultsProgressive frontal dominant cerebral, diffuse cerebellar cortical, and severe hippocampal atrophy were observed in seven patients with irreversible severe motor and intellectual deterioration. All of these seven patients exhibited status epilepticus and required transient respiratory care. Isolated diffuse cerebellar cortical atrophy was observed in two adult patients with mild motor regression. Five patients without apparent deterioration displayed almost normal brain findings.ConclusionsThe areas of atrophy were consistent with the areas of increased expression of the Na+/K+‐ATPase α3 subunit encoded by ATP1A3. Some of paroxysmal and nonparoxysmal neurological symptoms are considered as related to the areas of brain atrophy.
A multiband microstrip patch antenna with defected ground structure for its applications
Authors: Kishore Nand , Prakash Arun , Tripathi V. S. 
Published: September 2016

ABSTRACTThis article describes a circularly polarized multiband microstrip patch antenna for ITS applications. The proposed antenna works for six band. The proposed antenna can be used for Dedicated Short Range Communication, Global Positioning System, WiMAX, etc. It has a modified T shaped patch and a defected ground for improved performance. The proposed antenna at 5.9 GHz frequency gives 17% of bandwidth, which makes it suitable for modern ITS applications. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2814–2818, 2016
Generalized design of continuous‐mode second harmonic tuned amplifiers
Authors: Sharma Tushar , Darraji Ramzi , Mousavi Pedram , Ghannouchi F.M. 
Published: September 2016

ABSTRACTThis article presents generalized design equations for achieving broadband second harmonic tuned power amplifiers (PAs) that are operated in class‐B, class‐AB, or class‐A bias conditions. The investigation is carried out by deriving the general intrinsic drain current and voltage waveforms for conduction angle, α, varying between 180 and 360°. New impedance solutions are then extracted using the generalized current and voltage equations. Shifted fundamental design space and expanded second harmonic impedance area are obtained when α is swept between 180 and 360°. A Gallium Nitride (GaN) fabricated PA is operated in class‐AB and delivers an output power greater than 40 dBm with minimum drain efficiency of 73% in the frequency band ranging from 500 to 950 MHz. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2787–2789, 2016