bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical models for GaN-based heterostructure-free normally off fin-shaped field-effect transistor
Authors: Hu Guangxi , Qiang Haisheng , Hu Shuyan , Liu Ran , Zheng Lirong , Zhou Xing 
Published: January 2017

Abstract
Analytical models for threshold voltage and subthreshold swing of GaN-based fin-shaped field-effect transistors (FinFETs) are obtained. Analytical expressions for the drain-induced barrier lowering effect and threshold voltage roll-off effect are presented. The explicit expressions for threshold voltage and subthreshold swing make the model suitable for being embedded in circuit simulations and design tools.
Lærernes arbeidstid i Kunst og håndverk – grunnlaget for gammeldags leseplikt i grunnskolen
Authors: Lie Catrine , Nielsen Liv Merete 
Published: January 2017

En lærer i faget Kunst og håndverk på ungdomstrinnet har mindre tid til for- og etterarbeid enn lærere i andre fag. I denne artikkelen søker vi etter opphavet til denne differensieringen av lærernes arbeidstid og finner det i Lesepliktutvalgets utredning fra 1977. Der er det imidlertid ingen gode begrunnelser for hvorfor fagene får ulik leseplikt. Ti år senere legger Utvalget til å vurdere undervisningspersonalets fremtidige arbeidssituasjon (UFA-utvalget) beskrivelsene i de enkelte fagplanene til grunn for vurdering av lærernes leseplikt. Selv ikke etter innføringen av L97, der faget Kunst og håndverk fikk tydeligere innhold og lærerne større arbeidsbyrde, ble forskjellene i lærernes tid til for- og etterarbeid endret. Lærere har påpekt skjevheten, men leseplikten har forblitt uendret. Skoleledere har imidlertid gitt uttrykk for at leseplikten er rettferdig. I denne artikkelen drøfter vi hva som kan ligge til grunn for opprettholdelsen av denne gammeldagse leseplikten.
Effects of an 8-week yoga program on sustained attention and discrimination function in children with attention deficit hyperactivity disorder
Authors: Chou Chien-Chih , Huang Chung-Ju 
Published: January 2017

This study investigated whether a yoga exercise intervention influenced the sustained attention and discrimination function in children with ADHD. Forty-nine participants (mean age = 10.50 years) were assigned to either a yoga exercise or a control group. Participants were given the Visual Pursuit Test and Determination Test prior to and after an eight-week exercise intervention (twice per week, 40 min per session) or a control intervention. Significant improvements in accuracy rate and reaction time of the two tests were observed over time in the exercise group compared with the control group. These findings suggest that alternative therapies such as yoga exercises can be complementary to behavioral interventions for children with attention and inhibition problems. Schools and parents of children with ADHD should consider alternatives for maximizing the opportunities that children with ADHD can engage in structured yoga exercises.
MAVEN observations of the solar cycle 24 space weather conditions at Mars
Authors: Lee C. O. , Hara T. , Halekas J. S. , Thiemann E. , Chamberlin P. , Eparvier F. , Lillis R. J. , Larson D. E. , Dunn P. A. , Espley J. R. , Gruesbeck J. , Curry S. M. , Luhmann J. G. , Jakosky B. M. 
Published: January 2017

AbstractThe Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft has been continuously observing the variability of solar soft X‐rays and EUV irradiance, monitoring the upstream solar wind and interplanetary magnetic field conditions and measuring the fluxes of solar energetic ions and electrons since its arrival to Mars. In this paper, we provide a comprehensive overview of the space weather events observed during the first ∼1.9 years of the science mission, which includes the description of the solar and heliospheric sources of the space weather activity. To illustrate the variety of upstream conditions observed, we characterize a subset of the event periods by describing the Sun‐to‐Mars details using observations from the MAVEN solar Extreme Ultraviolet Monitor, solar energetic particle (SEP) instrument, Solar Wind Ion Analyzer, and Magnetometer together with solar observations using near‐Earth assets and numerical solar wind simulation results from the Wang‐Sheeley‐Arge‐Enlil model for some global context of the event periods. The subset of events includes an extensive period of intense SEP electron particle fluxes triggered by a series of solar flares and coronal mass ejection (CME) activity in December 2014, the impact by a succession of interplanetary CMEs and their associated SEPs in March 2015, and the passage of a strong corotating interaction region (CIR) and arrival of the CIR shock‐accelerated energetic particles in June 2015. However, in the context of the weaker heliospheric conditions observed throughout solar cycle 24, these events were moderate in comparison to the stronger storms observed previously at Mars.
Synthesis of 1‐Difluoroalkylated Isoquinolines via Palladium‐Catalyzed Radical Cascade Difluoroalkylation–Cyclization of Vinyl Isocyanides with Bromodifluoroacetic Derivatives
Authors: Liu Yingle , Zhang Ke , Jiang Weidong , Yang Yi , Jiang Yan , Liu Xiaoqiang , Xie Ying , Wu Jincai , Cai Junjie , Xu Xiu‐Hua 
Published: January 2017

AbstractA general method was developed for the synthesis of 1‐difluoroalkyl isoquinolines via the palladium‐catalyzed radical cascade difluoroalkylation–cyclization of vinyl isocyanides with bromodifluoroacetic derivatives. The difluoroalkylated cyclization products were readily converted to various other valuable gem‐difluoro‐containing compounds.
Robust Stability and Stabilization Of TCP‐Networked Control Systems with Multiple Delay System Modeling
Authors: Azadegan Masoumeh , Beheshti Mohammad T. H. 
Published: January 2017

AbstractThis paper presents a new model for networked control systems (NCSs) under transmission control protocol (TCP) as a multiple‐delay system by considering both sensor to controller and controller to actuator delays. An analytical TCP model has been considered for the network part, and an active queue management (AQM) controller is designed to regulate the desired queue length, which ensures holding the network induced delay and its variation within their lower bounds. The model is assumed to possess structured uncertainties due to the stochastic nature of the network. Robust stability and stabilization conditions are derived in terms of linear matrix inequalities (LMIs) by applying the Lyapunov‐Krasovskii stability criterion. Illustrative examples are presented and it has been shown that the proposed method will obtain less conservative results compared to the existing approaches in the literature.
Dorsal pallidal neurons directly link the nidopallium and midbrain in the zebra finch (Taeniopygia guttata)
Authors: Wild J. Martin 
Published: January 2017

AbstractThe dorsal pallidum in birds is considered similar, if not homologous, to the globus pallidus (GP) of mammals. The dorsal pallidum projects to both thalamic and midbrain targets similar to the direct and indirect pathways arising from the internal and external segments of the GP. In the present study, retrograde and anterograde tracing studies revealed a previously undescribed projection of the avian dorsal pallidum. This arises from a specific dorsomedial component, which terminates in the intercollicular nucleus and partly surrounds the avian equivalent of the central nucleus of the inferior colliculus. The respiratory‐vocal dorsomedial nucleus of the intercollicular complex, however, does not receive these projections.The somata of the pallidal neurons retrogradely labeled from injections in the intercollicular nucleus were large and generally multipolar and had extensive, sparsely branching central processes (presumptive dendrites) that together extended up to 2 mm dorsally into the intermediate and caudomedial nidopallium. The size and morphology of these neurons were similar to those of large pallidal neurons labeled by calretinin immunoreactivity, which could be co‐localized to the same cells. Thus, rather than being directly involved in the control of movement, the large dorsomedial neurons of the caudal dorsal pallidum may be involved in sensory processing, in that they provide an unusual direct link between sensory (auditory/somatosensory) regions of the nidopallium and sensory regions of the intercollicular nucleus of the midbrain. J. Comp. Neurol. 525:1731–1742, 2017. © 2016 Wiley Periodicals, Inc.
Radical and Diradical Formation in Naphthalene Diimides through Simple Chemical Oxidation
Authors: Lee Sangsu , Miao Fang , Phan Hoa , Herng Tun Seng , Ding Jun , Wu Jishan , Kim Dongho 
Published: January 2017

AbstractWe successfully synthesized, for the first time, a naphthalene diimide (NDI) radical and diradical by simple chemical oxidation using lead(IV) dioxide. The formation of the (di)radical is confirmed by UV/Vis/NIR absorption, 1H NMR, and electron paramagnetic resonance (EPR) measurements. In particular, temperature‐dependent EPR, SQUID (superconducting quantum interference device) measurements, and quantum calculations demonstrated that the generated NDI diradical has a singlet diradical character of y=0.69 in the ground state. Subsequent characterization of this (di)radical revealed its stabilities, large two‐photon absorption cross‐section, and short excited‐state lifetime.
Effect of alkylglycerol‐rich oil and rosemary extract on oxidative stability and antioxidant properties of a cooked meat product
Authors: Martin Diana , Salas‐Perez Lilia , Villalva Marisol , Vázquez Luis , Garcia‐Risco Monica R. , Jaime Laura , Reglero Guillermo 
Published: January 2017

Taking into account the bioactive and healthy properties of alkylglycerols (AKG) and the antioxidant rosemary extract (RE), the production of a cooked meat product with partial replacement of animal fat by AKG‐rich oil and inclusion of RE was performed. Six batches were manufactured: Control, control + RE (0.045%RE); low‐AKG (0.75%AKG‐oil), low‐AKG + RE (0.75%AKG‐oil + 0.045%RE); high‐AKG (4.3%AKG‐oil) and high‐AKG + RE (4.3%AKG‐oil + 0.045%RE). Fatty acid and lipid profile, changes on lipid oxidation (TBARS), antioxidant ability (TEAC), and carnosic acid were determined during refrigerated storage (0, 30, 60 days). A relevant replacement of animal fat by AKG‐rich oil was obtained (around 20% for the high‐AKG samples), together with healthier indexes of the fatty acid profile. A slight trend to worse lipid oxidation due to addition of AKG‐rich oil was measured, but being only significantly higher for the high‐AKG treatment in absence of RE. A significant better stability was measured due to inclusion of RE for all the treatments. Therefore, the oxidation of both low‐AKG + RE and high‐AKG + RE treatments were significantly comparable to the control batch. After storage, TBARS values increased for all the batches. Samples containing RE showed better TEAC values after the storage. In agreement, the amount of carnosic acid kept constant during the self‐life of the products.Practical applications: Cooked meat products combining the bioactive ingredients AKG‐rich oil and RE might be produced, without compromising the oxidative stability and with potential healthier and functional interest due to AKG enrichment, healthier fatty acid indexes, and antioxidant activity. Furthermore, the amount of one of the main bioactive compounds of RE, carnosic acid, would be preserved during the storage of the meat products, regardless of the addition of labile oils such as AKG‐rich oil.Taking into account the bioactive and healthy properties of alkylglycerols (AKG) and the antioxidant rosemary extract (RE), the production of a cooked meat product with partial replacement of animal fat by AKG‐rich oil and inclusion of RE was performed. Meat products combining both bioactive ingredients might be produced, without compromising the oxidative stability and with potential healthier and functional interest.
Substrate selectivity and optimization of immobilized SMG1‐F278N lipase in synthesis of propylene glycol monooleate
Authors: Li Xingxing , Liu Pengzhan , Khan Faez Iqbal , Li Daoming , Yang Bo , Wang Yonghua 
Published: January 2017

In the present study, the immobilized SMG1‐F278N lipase was employed for the esterification of 1,3‐propylene glycol with oleic acid. This was the first report of using mono‐ and diacylglycerol lipase for the production of propylene glycol monoesters (PGME). It was found that immobilized SMG1‐F278N preferred 1,3‐propylene glycol than 1,2‐propylene glycol. Molecular docking of 1,2‐propylene glycol and 1,3‐propylene glycol into SMG1‐F278N suggested that the 1,3‐propylene glycol preferentially binds to the active pocket of SMG1‐F278N as compared to 1,2‐propylene glycol. The maximum 1,3‐propylene glycol monooleate content of 70.67% was obtained under the reaction conditions of 1,3‐propylene glycol/oleic acid ratio of 5:1 (mol/mol), enzyme loading of 7.5% (w/w, with respect to total substrates), and water addition of 7% (w/w, with respect to total substrates) at 30°C. The present work offers insights into the selectivity of immobilized SMG1‐F278N towards 1,2‐propylene glycol and 1,3‐propylene glycol, and suggests the extended applications of immobilized SMG1‐F278N for industrial purpose.Practical applications: To our knowledge, the production of PGME using mono‐ and diacylglycerol lipases was reported for the first time. This study could contribute to develop potential applications of immobilized SMG1‐F278N in industries.1,2‐Propylene glycol/1,3‐propylene glycol docked into the catalytic pocket of SMG1‐F278N, esterification of 1,2‐propylene glycol/1,3‐propylene glycol with oleic acid catalyzed by immobilized SMG1‐278N and optimization of production of 1,3‐propylene glycol monooleate.
Synthesis, characterization, antimicrobial activity, and QSAR studies of some new 6‐substituted phenyl 3‐(4‐chlorophenyl)‐3a,4,8,8a‐tetrahydro‐[1,3,2]dioxaborepino [5,6‐d]isoxazoles
Authors: Pir Meryem , Agirbas Hikmet , Budak Fatma , Sahin Onur 
Published: January 2017

Abstract3‐(4‐Chlorophenyl)‐3a,4,8,8a‐tetrahydro‐[1,3,2]dioxaborepino[5,6‐d] isoxazoles were synthesized from the reaction of (3‐(4‐chlorophenyl)‐4,5‐dihydroisoxazole‐4,5‐diyl)dimethanol with substituted phenylboronic acids. Crystal structure of 1‐(4‐(3‐(4‐chlorophenyl)‐3a,4,8,8a‐tetrahydro‐[1,3,2]dioxaborepino[5,6‐d]isoxazol‐6‐yl)phenyl) ethanone was studied and the values of selected bond distances (Å), bond angles (°), and dihedral angles (°) were found in agreement with the calculated (DFT, B3LYP/6‐311++G(d,p)) values. Antimicrobial activity of these new compounds was also studied against a panel of microorganisms including Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Streptococcus mutans, and Candida albicans. Most of the dioxaborepines exhibited fair activities against these microorganisms. The pMIC values of the compounds were first correlated with Hammett polar substituent constant (σ) together with lipophilic constant (π) and statistically significant 2D correlations were obtained. In addition, the pMIC values of the compounds were correlated with some theoretical descriptors and fair 2D‐QSAR models with clogP, SAA, and μ as independent variables were obtained.
Feedback predictive control strategies for investment in the financial market with serially correlated returns subject to constraints and trading costs
Authors: Dombrovskii Vladimir , Obedko Tatiana 
Published: January 2017

SummaryIn this paper, we consider the optimal portfolio selection problem subject to hard constraints on trading amounts, trading costs, and different rates for borrowing and lending when the risky asset returns are serially correlated. We consider both explicit and implicit trading costs. No assumptions about the correlation structure between different time points or about the distribution of asset returns are needed. The problem is stated as a dynamic tracking problem of a reference portfolio with a desired return. We leverage the methodology of model predictive control (also known as receding horizon control) to design feedback portfolio optimization strategies and to provide a numerically tractable algorithm for practical applications. All expressions are presented in terms of first‐ and second‐order conditional moments. Our approach is tested on sets of real data from the Russian Stock Exchange Moscow Interbank Currency Exchange and New York Stock Exchange.
The intrinsically disordered linker of E. coliSSB is critical for the release from single‐stranded DNA
Authors: Tan Hui Yin , Wilczek Luke A. , Pottinger Sasheen , Manosas Maria , Yu Cong , Nguyenduc Trong , Bianco Piero R. 
Published: January 2017

AbstractThe Escherichia coli single stranded DNA binding protein (SSB) is crucial for DNA replication, recombination and repair. Within each process, it has two seemingly disparate roles: it stabilizes single‐stranded DNA (ssDNA) intermediates generated during DNA processing and, forms complexes with a group of proteins known as the SSB‐interactome. Key to both roles is the C‐terminal, one‐third of the protein, in particular the intrinsically disordered linker (IDL). Previously, they have shown using a series of linker deletion mutants that the IDL links both ssDNA and target protein binding by mediating interactions with the oligosaccharide/oligonucleotide binding fold in the target. In this study, they examine the role of the linker region in SSB function in a variety of DNA metabolic processes in vitro. Using the same linker mutants, the results show that in addition to association reactions (either DNA or protein), the IDL is critical for the release of SSB from DNA. This release can be under conditions of ssDNA competition or active displacement by a DNA helicase or recombinase. Consistent with their previous work these results indicate that SSB linker mutants are defective for SSB–SSB interactions, and when the IDL is removed a terminal SSB–DNA complex results. Formation of this complex inhibits downstream processing of DNA by helicases such as RecG or PriA as well as recombination, mediated by RecA. A model, based on the evidence herein, is presented to explain how the IDL acts in SSB function.
Association between Zika virus and fetopathy: a prospective cohort study in French Guiana
Authors: Pomar L. , Malinger G. , Benoist G. , Carles G. , Ville Y. , Rousset D. , Hcini N. , Pomar C. , Jolivet A. , Lambert V. 
Published: January 2017

ABSTRACTObjectiveTo establish the incidence of fetal central nervous system (CNS) anomalies (including microcephaly), signs of congenital infection and fetal loss in pregnant women infected with Zika virus (ZIKV) and non‐infected pregnant women in western French Guiana.MethodsThis prospective cohort study was conducted between 1 January and 15 July 2016. We evaluated and compared clinical and fetal ultrasound examinations of 301 pregnant women with biological confirmation of ZIKV infection and 399 pregnant women who were negative for ZIKV infection.ResultsOverall, the total number of fetuses with CNS involvement was higher in the infected than in the control group (9.0% vs 4.3%; relative risk, 2.11 (95% CI, 1.18–4.13)). Anomalies of the corpus callosum and presence of cerebral hyperechogenicities were significantly more common in the infected group. There was an increased risk of microcephaly in the infected compared with the control group (1.7% vs 0.3%; relative risk, 6.63 (95% CI, 0.78–57.83)), although this was not statistically significant. When the mother was infected during the first or second trimester, there was a greater risk of severe CNS involvement, more signs of infection and intrauterine fetal death than with infection in the third trimester. The rate of vertical transmission in the exposed group was 10.9%.ConclusionZIKV infection during pregnancy is associated with a significant risk of fetal CNS involvement and intrauterine fetal death, particularly when infection occurs during the first or second trimesters. Microcephaly was not present in every case of congenital ZIKV syndrome that we observed. Until more is known about this disease, it is paramount to evaluate suspected cases by detailed neurosonography on a monthly basis, paying particular attention to the corpus callosum and the presence of hyperechogenic foci. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Periconceptional maternal ‘high fish and olive oil, low meat’ dietary pattern is associated with increased embryonic growth: The Rotterdam Periconceptional Cohort (Predict) Study
Authors: Parisi F. , Rousian M. , Huijgen N. A. , Koning A. H. J. , Willemsen S. P. , de Vries J. H. M. , Cetin I. , Steegers E. A. P. , Steegers‐Theunissen R. P. M. 
Published: January 2017

ABSTRACTObjectiveTo investigate the association between periconceptional maternal dietary pattern and first‐trimester embryonic growth.MethodsThis was a prospective cohort study of 228 women with a singleton ongoing pregnancy, of which 135 were strictly dated spontaneous pregnancies and 93 were pregnancies achieved after in‐vitro fertilization or intracytoplasmatic sperm injection (IVF/ICSI). All women underwent serial transvaginal three‐dimensional ultrasound (3D‐US) examinations from 6 + 0 to 13 + 0 weeks' gestation. Crown–rump length (CRL) and embryonic volume (EV) measurements were performed using a virtual reality system. Information on periconceptional maternal dietary intake was collected via food frequency questionnaires. Principal component analysis was performed to identify dietary patterns. Associations between dietary patterns and CRL and EV trajectories were investigated using linear mixed models adjusted for potential confounders.ResultsA median of five (range, one to seven) 3D‐US scans per pregnancy were performed. Of 1162 datasets, quality was sufficient to perform CRL measurements in 991 (85.3%) and EV measurements in 899 (77.4%). A dietary pattern comprising high intake of fish and olive oil and a very low intake of meat was identified as beneficial for embryonic growth. In strictly dated spontaneous pregnancies, strong adherence to the ‘high fish and olive oil, low meat’ dietary pattern was associated with a 1.9 mm (95% CI, 0.1–3.63 mm) increase in CRL (+14.6%) at 7 weeks and a 3.4 mm (95% CI, 0.2–7.81 mm) increase (+6.9%) at 11 weeks, whereas EV increased by 0.06 cm3 (95% CI, 0.01–0.13 cm3) (+20.4%) at 7 weeks and 1.43 cm3 (95% CI, 0.99–1.87 cm3) (+14.4%) at 11 weeks. No significant association was observed in the total study population or in the IVF/ICSI subgroup.ConclusionPericonceptional maternal adherence to a high fish and olive oil, low meat dietary pattern is positively associated with embryonic growth in spontaneously conceived pregnancies. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Insights into nuclear dynamics using live‐cell imaging approaches
Authors: Bigley Rachel B. , Payumo Alexander Y. , Alexander Jeffrey M. , Huang Guo N. 
Published: January 2017

The nucleus contains the genetic blueprint of the cell and myriad interactions within this subcellular structure are required for gene regulation. In the current scientific era, characterization of these gene regulatory networks through biochemical techniques coupled with systems‐wide ‘omic’ approaches has become commonplace. However, these strategies are limited because they represent a mere snapshot of the cellular state. To obtain a holistic understanding of nuclear dynamics, relevant molecules must be studied in their native contexts in living systems. Live‐cell imaging approaches are capable of providing quantitative assessment of the dynamics of gene regulatory interactions within the nucleus. We survey recent insights into what live‐cell imaging approaches have provided the field of nuclear dynamics. In this review, we focus on interactions of DNA with other DNA loci, proteins, RNA, and the nuclear envelope. WIREs Syst Biol Med 2017, 9:e1372. doi: 10.1002/wsbm.1372This article is categorized under:

Models of Systems Properties and Processes > Cellular Models
Laboratory Methods and Technologies > Imaging