bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Parameterized Internal Wave Drag on the Semidiurnal Energy Balance in a Global Ocean Circulation Model
Authors: Buijsman Maarten C. , Ansong Joseph K. , Arbic Brian K. , Richman James G. , Shriver Jay F. , Timko Patrick G. , Wallcraft Alan J. , Whalen Caitlin B. , Zhao ZhongXiang 
Published: February 2016

AbstractThe effects of a parameterized linear internal wave drag on the semidiurnal barotropic and baroclinic energetics of a realistically forced, three-dimensional global ocean model are analyzed. Although the main purpose of the parameterization is to improve the surface tides, it also influences the internal tides. The relatively coarse resolution of the model of ~8 km only permits the generation and propagation of the first three vertical modes. Hence, this wave drag parameterization represents the energy conversion to and the subsequent breaking of the unresolved high modes. The total tidal energy input and the spatial distribution of the barotropic energy loss agree with the Ocean Topography Experiment (TOPEX)/Poseidon (TPXO) tidal inversion model. The wave drag overestimates the high-mode conversion at ocean ridges as measured against regional high-resolution models. The wave drag also damps the low-mode internal tides as they propagate away from their generation sites. Hence, it can be considered a scattering parameterization, causing more than 50% of the deep-water dissipation of the internal tides. In the near field, most of the baroclinic dissipation is attributed to viscous and numerical dissipation. The far-field decay of the simulated internal tides is in agreement with satellite altimetry and falls within the broad range of Argo-inferred dissipation rates. In the simulation, about 12% of the semidiurnal internal tide energy generated in deep water reaches the continental margins.
Independent Benthic Microbial Fuel Cells Powering Sensors and Acoustic Communications with the MARS Underwater Observatory
Authors: Schrader Paul S. , Reimers Clare E. , Girguis Peter , Delaney Jennifer , Doolan Cody , Wolf Michael , Green Dale 
Published: February 2016

AbstractMost oceanographic instruments on the seafloor have no connections with the surface and therefore have to run on batteries and store data until recovery. To demonstrate a developing technology, sensors and acoustic modems were powered with energy harvested from the seafloor, and data were relayed acoustically in near–real time to the Monterey Accelerated Research System (MARS) observatory in Monterey Bay, California, and to surface research vessels. MARS is a cabled observatory in deep water (~890 m) at the edge of Monterey Canyon. An acoustic modem was attached to the MARS node and configured to send out commands to, and relay data received from, remote modems. Two benthic microbial fuel cells (BMFCs) positioned approximately 0.5 km away from MARS supplied power to the remote modems and sensors. At their peak performance, these BMFCs produced continuous power densities of ~35 mW m−2 (footprint area). The modems utilized in this study contained an integrated power management platform (PMP) designed to manage and store the electrical energy generated by each BMFC and to record BMFC performance parameters and sensor data on an hourly basis. Temperature and either oxygen or conductivity sensors were chosen because of their common use and environmental relevance. Acoustically transmitted data records show that the BMFCs renewed energy stores and that the oceanographic sensors measured dissolved oxygen, temperature, and conductivity reliably throughout the operational life of each BMFC system (~6 months). These systems remained in place for more than 12 months.
Major Depression in Canada: What Has Changed over the Past 10 Years?
Authors: Patten Scott B. , Williams Jeanne V. A. , Lavorato Dina H. , Wang Jian Li , McDonald Keltie , Bulloch Andrew G. M. 
Published: February 2016

Objective: Major depressive episodes (MDE) make an important contribution to disease burden in Canada. The epidemiology of MDE in the national population has been examined in 2 mental health surveys, one conducted in 2002 and the other in 2012. Our objective was to compare selected variables from the 2 surveys to determine whether changes have occurred in the prevalence, treatment, and impact of MDE. Method: The World Health Organization World Mental Health Composite International Diagnostic Interview was used in both surveys and the MDE module (which was not modified) was scored using the same algorithm. Some variables assessing impact and management of MDE were also identical in the 2 surveys. The analysis was based on frequency estimates and associated 95% confidence intervals. Results: The annual prevalence of MDE was 4.7% (95% CI 4.3% to 5.1%) in 2012, nearly identical to 4.8% (95% CI 4.5% to 5.1%) in 2002. Receipt of potentially adequate treatment (defined as taking an antidepressant or 6 or more visits to a health professional for mental health reasons) increased from 41.3% in 2002 to 52.2% in 2012, mostly due to an increase in respondents reporting 6 or more visits. Use of second generation antipsychotics also increased. There was no evidence of diminishing prevalence or impact (as assessed by symptoms of distress). Conclusions: There appears to have been an increase in receipt of treatment for people with MDE and a changing pattern of management. However, it was not possible to confirm that the impact of MDE is diminishing as a result.
Forty-Five Years of Civil Litigation Against Canadian Psychiatrists: An Empirical Pilot Study
Authors: Mela Mansfield , Luther Glen , Gutheil Thomas G. 
Published: February 2016

Objectives: To extract the themes pertaining to prudent psychiatric practice from written court judgments in Canada. Methods: We searched the medical and legal literature for cases involving civil litigation against Canadian psychiatrist and reviewed all available written judgments. We completed a thematic analysis of the civil actions against psychiatrists as conveyed by those written court judgments. We classified the cases according to the disposal status and the essential lessons from the decisions on standard of care and practice by Canadian psychiatrists. Results: Forty such cases were identified as involving psychiatrists over a 45-year period. A subgroup included those dealing with limitation periods and disclosure applications. Thirty of the 40 cases (75%) were decided in favour of the defendant psychiatrists, including 2 dismissed for running over the limitation period. The cases that actually went to trial suggest that documentation and obtaining second opinions are protective against claims of negligence. Inpatient cases resulting in successful litigation against psychiatrists involved fatal outcomes, but not all fatal outcomes led to successful litigation. Conclusions: The key lessons from these cases are the importance and relevance of regular best clinical practices, such as documentation, obtaining second opinions, following guidelines, and balancing competencies in the expert and manager or advocate roles. Incorporating these practices should allay concerns about litigation against psychiatrists.
Career Interests of Canadian Psychiatry Residents: What Makes Residents Choose a Research Career?
Authors: Laliberté Vincent , Rapoport Mark J. , Andrew Melissa , Davidson Marla , Rej Soham 
Published: February 2016

Objectives: Training future clinician-researchers remains a challenge faced by Canadian psychiatry departments. Our objectives were to determine the prevalence of residents interested in pursuing research and other career options as part of their practice, and to identify the factors associated with interest in research. Method: Data from a national online survey of 207 Canadian psychiatry residents from a total of 853 (24.3% response rate) were examined. The main outcome was interest in research as part of residents’ future psychiatrist practice. Bivariate and multivariate analyses were performed to identify demographic and vocational variables associated with research interest. Results: Interest in research decreases by 76% between the first and fifth year of psychiatry residency (OR 0.76 per year, 95% CI 0.60 to 0.97). Training in a department with a residency research track did not correlate with increased research interest (χ2 = 0.007, df = 1, P = 0.93). Conclusions: Exposing and engaging psychiatry residents in research as early as possible in residency training appears key to promoting future research interest. Psychiatry residency programs and research tracks could consider emphasizing research training initiatives and protected research time early in residency.
Infrastructure for Water Resource Management in Southern Africa
Authors: Tumbare Michael James 
Published: February 2016

Water resources infrastructure ranges from educational and research infrastructure, storage works (surface and underground), hydrological and meteorological stations, irrigation systems, to water infrastructure for eco-tourism. This water resources infrastructure serves the mining, agricultural, urban and rural water needs, the environment, amongst a host of other needs and demands. Water resources infrastructure is a critical component in the provision of sustainable water resource management and services, for example, for mitigating impacts of climate change and variability, mitigating the variability of the water resource distribution in space and time, climate proofing, energy and food security and for data collection for information and improving the knowledge base. The purpose of this article is to document the status of water infrastructure development in the Southern African Development Community (SADC) region and showcase the efforts and strides that the SADC region has made and taken in achieving a conducive enabling environment for water infrastructure development to facilitate better water resource management. The article also highlights the challenges faced and the lessons learnt to date pursuant to the provision of water resource infrastructure in the SADC Region. The opinions and conclusions drawn in the article are those of the author.
Assaults from corrosive substances and medico legal considerations in a large regional burn centre in the United Kingdom: calls for increased vigilance and enforced legislation
Authors: Tan Alethea , Bharj Amrit Kaur , Nizamoglu Metin , Barnes David , Dziewulski Peter 
Published: February 2016

[Formula: see text] Burn injuries from corrosive substances have been recognised as a common method of assault in low and middle income countries (LMICs) motivated by various factors. Such injuries often leave survivors with severely debilitating physical and psychological injuries and scars. The number of reported cases of acid assaults within the United Kingdom (UK) appears to be on the rise. As one of the largest regional burn centres in the UK, we have reviewed our experience of chemical burns from assault. This study aims to: (1) review the demographics, incidence and patient outcomes; (2) evaluate the long-term psychosocial support provided; and (3) review current criminal litigation proceedings and preventative legislations in the UK specific to assault by corrosive substances. A 15-year retrospective review of 21 burn injuries from assault with corrosive substances presenting to a regional burn unit was conducted. Victims were mostly young men; male perpetrators were more common. The most common motive cited was assault. The most common anatomical region affected was the face and neck. The number of victims who pursue litigation is disproportionately lower than the number of total cases at presentation. In an effort to better understand the legal considerations surrounding such assaults, we also collaborated with lawyers experienced in this particular field. We hope that our work will help educate healthcare professionals regarding the legal assistance and existing laws available to protect these patients.
Ulinastatin administration is associated with a lower incidence of acute kidney injury after cardiac surgery: a propensity score matched study
Authors: Wan Xin , Xie Xiangcheng , Gendoo Yasser , Chen Xin , Ji Xiaobing , Cao Changchun 
Published: February 2016

Abstract
Background
Systemic inflammation is involved in the development of acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB). Ulinastatin, a urinary trypsin inhibitor (UTI), possesses a variety of anti-inflammatory effects. Therefore, we hypothesized that the administration of ulinastatin would reduce the occurrence of AKI in patients undergoing cardiac surgery with CPB.

Methods
A retrospective propensity score matched analysis was used to evaluate the effect of ulinastatin on the development of AKI in patients undergoing first documented cardiac surgery with CPB between January 2008 and December 2012 in our hospital. Multiple logistic regression models were also employed to identify the association between UTI administration and development of AKI.

Results
A total of 2072 patients who underwent cardiac surgery with CPB met the inclusion criteria. Before propensity score matching, variables such as age, baseline creatinine, CPB duration, red blood cells transfused, and hematocrit were statistically different between the ulinastatin (UTI) group and the control group. On the basis of propensity scores, 409 UTI patients were successfully matched to the 409 patients from among those 1663 patients without UTI administration. After propensity score matching, no statistically significant differences in the baseline characteristics were found between the UTI group and the control group. The propensity score matched cohort analysis revealed that AKI and the need for renal replacement therapy occurred more frequently in the control group than in the UTI group (40.83 % vs. 30.32 %, P = 0.002; 2.44 % vs. 0.49 %, P = 0.02, respectively). However, there were no significant differences in mortality, length of intensive care unit stay, and length of hospital stay between the UTI group and the control group. Using multivariate logistic regression analysis, we found ulinastatin played a protective role in the development of AKI after cardiac surgery (odds ratio 0.71, 95 % confidence interval 0.56–0.90, P = 0.005).

Conclusions
This study shows that ulinastatin was associated with a lower incidence of AKI after cardiac surgery, suggesting that the administration of ulinastatin may be favorable for those patients undergoing cardiac surgery with CPB.
Diagnosis and prognosis of neutrophil gelatinase-associated lipocalin for acute kidney injury with sepsis: a systematic review and meta-analysis
Authors: Zhang An , Cai Ying , Wang Peng-Fei , Qu Jian-Ning , Luo Zhen-Chun , Chen Xiao-Dong , Huang Bin , Liu Yi , Huang Wen-Qi , Wu Jing , Yin Yue-Hui 
Published: February 2016

Abstract
Background
Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as an early biomarker for prediction of acute kidney injury (AKI). However, the utility of NGAL to predict the occurrence of AKI in septic patients remains controversial. We performed a systematic review and meta-analysis to evaluate the evidence on diagnosis of sepsis AKI and the prediction of other clinical outcomes.

Method
The MEDLINE, EMBASE, Cochrane Library, Wanfang, and CNKI databases were systematically searched up to August 19, 2015. Quality assessment was applied by using the Quality Assessment for Studies of Diagnostic Accuracy (QUADAS-2) tool. The diagnostic performance of NGAL for the prediction of AKI in sepsis was evaluated using pooled estimates of sensitivity, specificity, likelihood ratio, and diagnostic odds ratio (DOR), as well as summary receiver operating characteristic curves (SROC).

Results
Fifteen studies with a total of 1,478 patients were included in the meta-analysis. For plasma NGAL, the pooled sensitivity and specificity with corresponding 95 % confidence intervals (CI) were 0.83 (95 % CI: 0.77 − 0.88) and 0.57 (95 % CI: 0.54 − 0.61), respectively. The pooled positive likelihood ratio (PLR) was 3.10 (95 % CI: 1.57 − 6.11) and the pooled negative likelihood ratio (NLR) was 0.24 (95 % CI: 0.13 − 0.43). The pooled DOR was 14.72 (95 % CI: 6.55 − 33.10) using a random effects model. The area under the curve (AUC) for SROC to summarize diagnostic accuracy was 0.86. For urine NGAL, the pooled sensitivity, specificity, PLR, NLR, DOR, and AUC values were 0.80 (95 % CI: 0.77 − 0.83), 0.80 (95 % CI: 0.77 − 0.83), 4.42 (95 % CI: 2.84 − 6.89), 0.21 (95 % CI: 0.13 − 0.35), 24.20 (95 % CI: 9.92 − 59.05) and 0.90, respectively. Significant heterogeneity was explored as a potential source. There was no notable publication bias observed across the eligible studies. NGAL for prediction of renal replacement therapy (RRT) and mortality associated with AKI in septic patients were also evaluated.

Conclusion
To a certain extent, NGAL is not only an effective predictive factor for AKI in the process of sepsis, but also shows potential predictive value for RRT and mortality. However, future trials are needed to clarify this controversial issue.
Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation
Authors: O’Keeffe Gerard W. , Gutierrez Humberto , Howard Laura , Laurie Christopher W. , Osorio Catarina , Gavaldà Núria , Wyatt Sean L. , Davies Alun M. 
Published: February 2016

Abstract

Background
Nerve growth factor (NGF) is the prototypical target-derived neurotrophic factor required for sympathetic neuron survival and for the growth and ramification of sympathetic axons within most but not all sympathetic targets. This implies the operation of additional target-derived factors for regulating terminal sympathetic axon growth and branching.

Results
Here report that growth differentiation factor 5 (GDF5), a widely expressed member of the transforming growth factor beta (TGFβ) superfamily required for limb development, promoted axon growth from mouse superior cervical ganglion (SCG) neurons independently of NGF and enhanced axon growth in combination with NGF. GDF5 had no effect on neuronal survival and influenced axon growth during a narrow window of postnatal development when sympathetic axons are ramifying extensively in their targets in vivo. SCG neurons expressed all receptors capable of participating in GDF5 signaling at this stage of development. Using compartment cultures, we demonstrated that GDF5 exerted its growth promoting effect by acting directly on axons and by initiating retrograde canonical Smad signalling to the nucleus. GDF5 is synthesized in sympathetic targets, and examination of several anatomically circumscribed tissues in Gdf5 null mice revealed regional deficits in sympathetic innervation. There was a marked, highly significant reduction in the sympathetic innervation density of the iris, a smaller though significant reduction in the trachea, but no reduction in the submandibular salivary gland. There was no reduction in the number of neurons in the SCG.

Conclusions
These findings show that GDF5 is a novel target-derived factor that promotes sympathetic axon growth and branching and makes a distinctive regional contribution to the establishment of sympathetic innervation, but unlike NGF, plays no role in regulating sympathetic neuron survival.
Attenuation of teratoma formation by p27 overexpression in induced pluripotent stem cells
Authors: Matsu-ura Toru , Sasaki Hiroshi , Okada Motoi , Mikoshiba Katsuhiko , Ashraf Muhammad 
Published: February 2016

Abstract
Background
Pluripotent stem cells, such as embryonic stem cells or induced pluripotent stem cells, have a great potential for regenerative medicine. Induced pluripotent stem cells, in particular, are suitable for replacement of tissue by autologous transplantation. However, tumorigenicity is a major risk in clinical application of both embryonic stem cells and induced pluripotent stem cells. This study explores the possibility of manipulating the cell cycle for inhibition of tumorigenicity.

Methods
We genetically modified mouse induced pluripotent stem cells (miPSCs) to overexpress p27 tumor suppressor and examined their proliferation rate, gene expression, cardiac differentiation, tumorigenicity, and therapeutic potential in a mouse model of coronary artery ligation.

Results
Overexpression of p27 inhibited cell division of miPSCs, and that inhibition was dependent on the expression level of p27. p27 overexpressing miPSCs had pluripotency characteristics but lost stemness earlier than normal miPSCs during embryoid body and teratoma formation. These cellular characteristics led to none or smaller teratoma when the cells were injected into nude mice. Transplantation of both miPSCs and p27 overexpressing miPSCs into the infarcted mouse heart reduced the infarction size and improved left ventricular function.

Conclusions
The overexpression of p27 attenuated tumorigenicity by reducing proliferation and earlier loss of stemness of miPSCs. The overexpression of p27 did not affect pluripotency and differentiation characteristics of miPSC. Therefore, regulation of the proliferation rate of miPSCs offers great therapeutic potential for repair of the injured myocardium.
Near-surface geophysical investigation of the 2010 Haiti earthquake epicentral area: Léogâne, Haiti
Authors: Kocel Eray , Stewart Robert R. , Mann Paul , Chang Li 
Published: February 2016

The [Formula: see text] Léogâne fan delta in southwestern Haiti borders the epicentral region of the devastating magnitude 7.0 Haiti earthquake of 12 January 2010. The flat plain of the Léogâne area experienced some of the worst shaking, destruction of buildings, and loss of life caused by the Haiti earthquake. This intense shaking was attributed by previous workers to either activation of a blind (no surface expression) thrust fault some 4 km beneath the Léogâne fan delta or to strike-slip motion along a shallow, ground-breaking fault that ruptured the uppermost part of the fan delta. Our research team from the University of Houston and the Haiti Bureau of Mines and Energy collected shallow seismic and gravity data in the fan delta where previous studies of earthquake aftershocks, coastal uplift of coral reefs, and radar interferometry all indicated a maximum amount of coseismic uplift. Our objective was to acquire geophysical information on the subsurface stratigraphy, structure, and material properties of the fan. S-wave seismic studies revealed an average velocity of [Formula: see text] for the first 30 m. These velocity values suggest that the near-surface sediments at Léogâne are a seismically hazardous class D sediment type (National Earthquake Hazard Reduction Program). Interpretation of our various seismic data sets has indicated prolonged sedimentary environments of fluvial channeling and channel migration to a depth of approximately 350 m as expected in this fan delta setting. There was no clear evidence on our seismic reflection lines for substantial faulting in the seismically slow, shallow fan delta sediments. Integrated geophysical data analyses indicated south-dipping seismically slow layers on the southern end of the Léogâne fan with a less well defined northward dip with the broad, anticlinal axis aligned with the area of maximum coseismic uplift at the coast. The sudden, coseismic upheaval of the ground surface above the proposed blind thrust combined with extreme shaking of the seismically weak sediments contributed to the destructiveness of the earthquake on the Léogâne fan delta.