bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin Concentrations and Antioxidative Capacity of Human Breast Milk According to Gestational Age and the Time of Day
Authors: Katzer David , Pauli Lisa , Mueller Andreas , Reutter Heiko , Reinsberg Jochen , Fimmers Rolf , Bartmann Peter , Bagci Soyhan 
Published: April 2016

Background: While changes in the composition of breast milk throughout the lactation period are well known, little is known about the antioxidative capacity of breast milk and its regulation as a function of time of day. Objective: The aim of this study was to evaluate the antioxidative capacity in breast milk and its regulation by time of day. Methods: Melatonin, superoxide dismutase (SOD), glutathione peroxidase 3 (Gpx3) concentrations, and the total antioxidative capacity (TAOC) were analyzed in 105 breast milk samples and 12 maternal serum samples from 21 healthy nursing mothers. Results: Comparison between daytime breast milk (collected from 1000-2200 h) and nighttime breast milk (collected from 2200-1000 h) revealed significantly higher concentrations of melatonin and Gpx3 in nighttime milk (melatonin: 1.5 pg/mL [1.0-2.1] day vs 7.3 pg/mL [3.8-13.6] night, median [quartiles], with an estimated mean night-to-day ratio of 5.2 [3.9, 7.1], P < .001; Gpx3: 1436 ng/mL [765-2060] day vs 1800 ng/mL [1242-2297] night, night-to-day difference 192.1 [0.6, 383.7], P = .049). Subgroup analysis showed that melatonin had a circadian rhythm in both preterm and term milk, with a significantly higher nighttime concentration ( P < .001), while antioxidant enzymes had a circadian rhythm only in preterm milk, with a significantly higher nighttime concentration for Gpx3 and a significant higher daytime concentration for SOD and TAOC ( P = .041 and P = .049, respectively). We found no significant correlation between the concentration of melatonin and the concentration of SOD, Gpx3, or TAOC. Moreover, there were no significant correlations observed between gestational age and the concentration of melatonin and antioxidant enzymes. Conclusion: Because of its higher melatonin and Gpx3 content, future research is needed to determine if preterm nighttime milk ought to be the first choice in the feeding of high-risk preterm infants.
‘I Wouldn’t Have What It Takes’
Authors: Sveningsson Malin 
Published: April 2016

Research on young people and citizenship has often depicted those who do not participate in manifest political contexts as ‘passive’. However, the space between ‘active’ and ‘passive’ is complex and hosts a number of different positions. Using a qualitative mixed methods approach, this article provides insights into how a group of young people, who can be described as ‘standby citizens’ (Amnå & Ekman, 2014), perceive political participation, and ultimately, why they, despite a strong interest in politics, are reluctant to describe themselves as ‘politically engaged’. Eight themes were identified and grouped into three categories focusing on different aspects: What forms engagement should take in order to count as such, what characteristics engaged persons were perceived to have and what political engagement was perceived to be about. All three contributed towards making the position ‘politically engaged’ difficult to claim, but also somewhat undesirable, for the participants.
Fructose-rich diet induces gender-specific changes in expression of the renin–angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta
Authors: Bundalo Maja M , Zivkovic Maja D , Romic Snjezana Dj , Tepavcevic Snezana N , Koricanac Goran B , Djuric Tamara M , Stankovic Aleksandra D 
Published: April 2016

Introduction: The cardiovascular renin–angiotensin system (RAS) could be affected by gender and dietary regime. We hypothesized that male rats will be more susceptible to activation of RAS in the heart and aorta, as a response to a fructose-rich diet (FRD). Materials and methods: Both male and female Wistar rats were given a 10% (w/v) fructose solution for 9 weeks. We measured the biochemical parameters, blood pressure (BP) and heart rate. We used Western blot and real-time polymerase chain reaction (PCR) to quantify protein and gene expression. Results: In the male rats, the FRD elevated BP and expression of cardiac angiotensin-converting enzyme (ACE), while the expression of angiotensin-converting enzyme 2 (ACE2) and angiotensin II Type 2 receptor (AT2R) were significantly decreased. In female rats, there were no changes in cardiac RAS expression due to FRD. Furthermore, the ACE/AT1R axis was overexpressed in the FRD male rats’ aortae, while only AT1R was upregulated in the FRD female rats’ aortae. ACE2 expression remained unchanged in the aortae of both genders receiving the FRD. Conclusions: The FRD induced gender-specific changes in the expression of the RAS in the heart and aortae of male rats. Further investigations are required in order to get a comprehensive understanding of the underlying mechanisms of gender-specific fructose-induced cardiovascular pathologies.
Aldosterone is associated with left ventricular hypertrophy in hemodialysis patients
Authors: Feniman De Stefano Greicy Mara Mengue , Zanati-Basan Silméia Garcia , De Stefano Laercio Martins , Silva Viviana Rugolo Oliveira e , Xavier Patrícia Santi , Barretti Pasqual , da Silva Franco Roberto Jorge , Caramori Jacqueline Costa Teixeira , Martin Luis Cuadrado 
Published: April 2016

Objectives: Patients with chronic kidney disease present a higher degree of left ventricular hypertrophy than expected for hypertension levels. In chronic kidney disease the plot between the quotient extracellular water/total body water and aldosterone is shifted up and to the right. There are few studies that verified the role of aldosterone in cardiac remodeling in this set of patients. The aim of this study was to evaluate the relationship between serum aldosterone and left ventricular mass index in patients with chronic kidney disease on hemodialysis. Methods: The patients were submitted to clinical and laboratory evaluation, bioelectrical impedance, echocardiography and ambulatory blood pressure monitoring. The 27 patients included were divided into two groups according to aldosterone level and compared with each other. Results: The group of patients with higher aldosterone levels had higher left ventricular mass index. These groups were heterogeneous with regard to ambulatory systolic blood pressure, body mass index, and aldosterone levels and homogeneous with regard to the quotient extracellular water/total body water, renin–angiotensin–aldosterone system blockers, beta blocker use and other clinical characteristics. The association between aldosterone levels and left ventricular mass index was adjusted to confounding variables by a multiple linear regression analysis in which aldosterone was independently associated with left ventricular mass index. Conclusion: The data presented are consistent with a pathogenic role of aldosterone in left ventricular hypertrophy in patients with chronic kidney dialysis in dialysis patients. Trial registration: ClinicalTrials.gov identifier: NCT01128101.
Shoulder injuries in adolescent rugby players
Authors: Hodhody Ghazal , Mackenzie Tanya A , Funk Lennard 
Published: April 2016

Background Rugby is a high-intensity contact sport, frequently causing shoulder injuries. Between the ages of 12 years to 18 years, academy and county level players are being selected for professional contracts, making this is a critical stage of their career. The present study aimed to describe the patterns of injury in adolescent rugby players with shoulder injuries. Methods Academy and county level rugby players in the target age group, over a 7-year period, were included in the present study. Data collected included the mechanism of injury, position and level of play, radiology and surgical findings, and recurrence rate at a minimum of 2 years post-surgery. Results One hundred and sixty-nine cases adhered to the inclusion criteria, with most cases involving two or more pathologies in the shoulder (54%). Forwards sustained more shoulder injuries than backs, incurring more labral injuries. By contrast, backs had a higher incidence of bony pathology. The mechanism of injury frequently correlated with player positions. There was a 21% injury recurrence rate, with forwards (7%) and higher level academy players (11%) most likely to suffer a recurrence. Conclusions Shoulder injury patterns in this important group of adolescent contact athletes are complex, with recurrence rates being higher than those in older rugby players.
Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies
Authors: McKerrell Thomas , Moreno Thaidy , Ponstingl Hannes , Bolli Niccolo , Dias João M. L. , Tischler German , Colonna Vincenza , Manasse Bridget , Bench Anthony , Bloxham David , Herman Bram , Fletcher Danielle , Park Naomi , Quail Michael A. , Manes Nicla , Hodkinson Clare , Baxter Joanna , Sierra Jorge , Foukaneli Theodora , Warren Alan J. , Chi Jianxiang , Costeas Paul , Rad Roland , Huntly Brian , Grove Carolyn , Ning Zemin , Tyler-Smith Chris , Varela Ignacio , Scott Mike , Nomdedeu Josep , Mustonen Ville , Vassiliou George S. 
Published: April 2016

Key Points
We develop and validate Karyogene, a comprehensive one-stop diagnostic platform for the genomic analysis of myeloid malignancies. Karyogene simultaneously detects substitutions, insertions/deletions, translocations, copy number and zygosity changes in a single assay.
Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome–positive ALL
Authors: Rousselot Philippe , Coudé Marie Magdelaine , Gokbuget Nicola , Gambacorti Passerini Carlo , Hayette Sandrine , Cayuela Jean-Michel , Huguet Françoise , Leguay Thibaut , Chevallier Patrice , Salanoubat Celia , Bonmati Caroline , Alexis Magda , Hunault Mathilde , Glaisner Sylvie , Agape Philippe , Berthou Christian , Jourdan Eric , Fernandes José , Sutton Laurent , Banos Anne , Reman Oumedaly , Lioure Bruno , Thomas Xavier , Ifrah Norbert , Lafage-Pochitaloff Marina , Bornand Anne , Morisset Laure , Robin Valérie , Pfeifer Heike , Delannoy Andre , Ribera Josep , Bassan Renato , Delord Marc , Hoelzer Dieter , Dombret Herve , Ottmann Oliver G. 
Published: April 2016

Key Points
Dasatinib, combined with low-intensity chemotherapy, gave 36% 5-year overall survival in Ph+ ALL patients older than age 55 years. Prospective monitoring of mutations may be useful to personalize therapy in Ph+ ALL patients not eligible for intensive therapies.
An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response
Authors: Brown Max , Strudwick Natalie , Suwara Monika , Sutcliffe Louise K. , Mihai Adina D. , Ali Ahmed A. , Watson Jamie N. , Schröder Martin 
Published: April 2016

ABSTRACT
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). In mammalian cells, UPR signals generated by several ER-membrane-resident proteins, including the bifunctional protein kinase endoribonuclease IRE1α, control cell survival and the decision to execute apoptosis. Processing of XBP1 mRNA by the RNase domain of IRE1α promotes survival of ER stress, whereas activation of the mitogen-activated protein kinase JNK family by IRE1α late in the ER stress response promotes apoptosis. Here, we show that activation of JNK in the ER stress response precedes activation of XBP1. This activation of JNK is dependent on IRE1α and TRAF2 and coincides with JNK-dependent induction of expression of several antiapoptotic genes, including cIap1 (also known as Birc2), cIap2 (also known as Birc3), Xiap and Birc6. ER-stressed Jnk1−/− Jnk2−/− (Mapk8−/− Mapk9−/−) mouse embryonic fibroblasts (MEFs) display more pronounced mitochondrial permeability transition and increased caspase 3/7 activity compared to wild-type MEFs. Caspase 3/7 activity is also elevated in ER-stressed cIap1−/− cIap2−/− and Xiap−/− MEFs. These observations suggest that JNK-dependent transcriptional induction of several inhibitors of apoptosis contributes to inhibiting apoptosis early in the ER stress response.
Understanding Bank-Run Contagion
Authors: Brown Martin , Trautmann Stefan T. , Vlahu Razvan 
Published: April 2016

We study experimental coordination games to examine through which transmission channels and under which information conditions a panic-based depositor run at one bank may trigger a panic-based depositor run at another bank. We find that withdrawals at one bank trigger withdrawals at another bank by increasing players’ beliefs that other depositors in their own bank will withdraw, making them more likely to withdraw as well. Observed withdrawals only affect depositors’ beliefs, and are thus contagious when they form an informative signal about bank fundamentals. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2416 . This paper was accepted by Amit Seru, finance.
The effect of rational emotive parent education program on parents’ irrational beliefs and parenting stress<p>Akılcı duygusal aile eğitim programının anne babaların akılcı olmayan inançlarına ve anne babalık streslerine etkisi
Authors: Çekiç Ali , Akbaş Turan , Hamamcı Zeynep 
Published: April 2016

The aim of the study is to investigate the effects of Rational Emotive Parent Education Program (REPEP) on parents’ irrational beliefs and parenting stress. In the study, a semi-experimental research design with a pre-test, post-test and follow-up measures on experimental and control group was used. While the first factor shows the independent procedures (like experimental and control groups), other factors show the repetitive measures in various conditions (like pre-test, post-test and follow-up measures) in relation to the dependent variable. It was studied at a state school in spring of 2013-2014 educational years. The experimental group consists of a total of 26 parents, including 4 fathers and 22 mothers. These groups include volunteer parents who scored a half standard deviation above in Parents’ Stress Scale (PSS) and Parents’ Irrational Beliefs Scale (PIBS). While the experimental group (n=13) received a 7-week Rational Emotive Parent Education Program, the control group (n=13) had no such education. The study results show that upon the experimental practice and follow-up processes, there is a decrease not only in parenting stress, but also in irrational beliefs of the experimental group. The results are also in accordance with the related literature. ÖzetBu araştırmanın amacı, Akılcı Duygusal Aile Eğitim Programının (ADAEP), anne babaların akılcı olmayan inançları ve anne babalık stresleri üzerindeki etkisini incelemektir. Araştırmada ön-test, son-test ve izleme ölçümlü, deney ve kontrol gruplu yarı deneysel bir desen kullanılmıştır. Bu desende birinci faktör bağımsız işlem gruplarını (deney ve kontrol) gösterirken, diğer faktör bağımlı değişkene ilişkin farklı koşullardaki tekrarlı ölçümleri (ön-test, son-test ve izleme ölçümü) göstermektedir. Çalışma 2013-2014 bahar yarıyılında bir devlet ilkokulunda gerçekleştirilmiştir. Deney grubu 4 baba, 22 anne olmak üzere 26 ebeveynden oluşmaktadır. Deney grupları Anne Baba Stres Ölçeği (ABSÖ) ile Anne Babaların Akılcı Olmayan İnançları Ölçeğinden (ABAOİÖ) ortalamanın yarım standart sapma üzerinde puan alan ve çalışmaya katılmaya gönüllü anne babalardan oluşturulmuştur. Deney grubuna (n=13) araştırmacı tarafından geliştirilen 7 haftalık ADAEP uygulanırken kontrol grubuna (n=13) herhangi bir çalışma yapılmamıştır. Araştırma sonuçları, deneysel işlem süreci ve üç aylık izleme dönemi sonunda deney grubunda yer alan anne babaların stres düzeylerinin düştüğünü, akılcı olmayan inançlarının azaldığını göstermektedir. Araştırma sonuçları ilgili literatürü destekler niteliktedir.
Postpartum hemorrhage in the setting of a mechanical heart valve
Authors: Perdigao Joana Lopes , McQueen Dana , Nunes Kenneth , DiGiovanni Laura 
Published: April 2016

Abstract

Background:
Therapeutic anticoagulation is required for all patients with prosthetic mitral valves. Anticoagulation with warfarin is recommended; however, warfarin is teratogenic in early pregnancy and therefore alternate anticoagulation regimens are suggested for pregnant patients.

Case:
A 28-year-old gravida 2, para 1 woman at 36 weeks’ gestation with a prosthetic mitral valve and a history of a corrected anomalous origin of the left coronary artery arising from the left pulmonary artery presented in labor. She underwent a spontaneous vaginal delivery complicated by a postpartum hemorrhage necessitating a hysterectomy.

Conclusion:
Management of mechanical valves in pregnancy is controversial. The provider must weigh the risks of life threatening valve thrombosis and malfunction against the risk of significant hemorrhage. This case report reviews peripartum anticoagulation protocols and management of massive hemorrhage in patients with prosthetic mechanical valves.
Fabrication and characterization of air-impedance electrospun polydioxanone templates
Authors: Selders Gretchen S. , Fetz Allison E. , Speer Shannon L. , Bowlin Gary L. 
Published: April 2016

AbstractElectrospinning, a fabrication technique used to create non-woven, porous templates from natural and synthetic polymers, is commonly used in tissue engineering because it is highly tailorable. However, traditional electrospinning creates restrictive pore sizes that limit the required cell migration. Therefore, tissue engineering groups have sought to enhance and regulate porosity of tissue engineering templates. Air-impedance electrospinning generates templates with tailorable, patterned areas of low and high density fiber deposition. Here we demonstrate an improved air-impedance electrospinning system, consisting of a newly designed funnel equipped to hold changeable porous deposition plates and administer air flow in a confined and focused manner, with parameters that maintain template integrity. In this preliminary study, we quantify the increase in porosity of polydioxanone templates with use of traditional fiber and pore analysis as well as with mercury porosimetry. Additionally, we validate the system’s significance in fabricating enhanced porosity templates that maintain their mechanical properties (i.e. elastic modulus, tensile strength, and suture retention strength) despite the deliberate increase in porosity. This is of exceptional value to the template’s integrity and efficacy as these parameters can be further optimized to induce the desired template porosity, strength, and texture for a given application.
EDD1 predicts prognosis and regulates gastric cancer growth in vitro and in vivo via miR-22
Authors: Yang Min , Jiang Nan , Cao Qi-wei , Sun Qing 
Published: April 2016

Abstract
Gastric cancer is the most common digestive malignant tumor worldwild. EDD1 was reported to be frequently amplified in several tumors and played an important role in the tumorigenesis process. However, the biological role and potential mechanism of EDD1 in gastric cancer remains poorly understood. In this study, we are aim to investigate the effect of EDD1 on gastric cancer progression and to explore the underlying mechanism. The results showed the significant up-regulation of EDD1 in -gastric cancer cell tissues and lines. The expression level of EDD1 was also positively associated with advanced clinical stages and predicted poor overall patient survival and poor disease-free patient survival. Besides, EDD1 knockdown markedly inhibited cell viability, colony formation, and suppressed tumor growth. Opposite results were obtained in gastric cancer cells with EDD1 overexpression. EDD1 knockdown was also found to induce gastric cancer cells apoptosis. Further investigation indicated that the oncogenic role of EDD1 in regulating gastric cancer cells growth and apoptosis was related to its PABC domain and directly through targeting miR-22, which was significantly down-regulated in gastric cancer tissues. Totally, our study suggests that EDD1 plays an oncogenic role in gastric cancer and may be a potential therapeutic target for gastric cancer.
Opportunities for disabled people through ICTs: a perspective from Turkey
Authors: Alkan Meshur H. Filiz 
Published: April 2016

AbstractInformation and communication technologies (ICTs), which have developed rapidly in recent years, have brought notable changes to human life. Additionally, the use of ICTs also has importance from the point of view of disabled people. Because of physical deficiencies, disabled people make more effort to access knowledge and services relative to healthy people. Also, they face some important constraints in urban spaces. The planning of urban spaces according to the requirements of disabled people is a necessity of being in a contemporary society. Furthermore, offering some opportunities for disabled people through ICTs should be considered. While healthy people do not have any limitations, disabled people face some important constraints in using these technologies. With this in mind, designing ICTs without considering disabled people will cause discrimination against them by society. In addition, e-learning and teleworking concepts, which have arisen together with ICTs, are an important perspective related to education and employment policies for disabled people. In this paper, the importance of considering the needs and problems of disabled people in accessing ICTs is emphasized, and also this paper aims to evaluate opportunities offered by new technologies for disabled people in Turkey. The uses of areas of ICTs seen as a tool in order to raise the quality of life of disabled people are evaluated, and the problems and opportunities are revealed. People with intellectual disabilities are not addressed within this study. Instead, it focuses on individuals with physical disabilities such as visual, hearing, and orthopedic impairment. Opportunities offered by ICTs for disabled people are evaluated. Also, recommendations are developed about the accessibility of disabled people to employment, education, health, and social and urban services in Turkey. Another aim of this paper is to create awareness for disabled people about the use of ICTs. Firstly, a literature review was done, and in addition to the print and electronic resources, suggestions and opinions were taken from public institutions and organizations. Furthermore, the needs and constraints of disabled people are explored for the use of ICTs by conducting in-depth interviews.
Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
Authors: Adongo Donatus Wewura , Mante Priscilla Kolibea , Edem Kukuia Kennedy Kwami , Ameyaw Elvis Ofori , Woode Eric , Azi Iliya Hosea 
Published: April 2016

Abstract

Background:

Pseudospondias microcarpa is a plant used for managing various diseases including CNS disorders. Previous studies showed sedative and anticonvulsant effects, suggesting possible anxiolytic activity. This study therefore assessed the anxiolytic effects of P. microcarpa hydroethanolic leaf extract (PME) in mice.

Methods:
In the present study, anxiolytic-like effect of the extract in behavioural paradigms of anxiety – the elevated plus maze (EPM), light/dark box (LDB), social interaction test and stress-induced hyperthermia (SIH) – was evaluated.

Results:
Mice treated with PME (30–300 mg kg−1, p.o.) exhibited anxiolytic-like activity similar to diazepam in all the anxiety models used. The extract increased open arm activity (p<0.05) in the EPM as well as increasing the time spent in the lit area in relation to the time spent in the dark area of the LDB. Sociability and preference for social novelty significantly (p<0.05–0.001) increased in mice treated with PME. In the SIH paradigm in mice, both PME and the benzodiazepine receptor agonist, diazepam, significantly (p<0.05) reduced the stress-induced increase in rectal temperature. The extract did not impair motor coordination and balance in the beam walk test.

Conclusions:
Results of the present study indicate that PME possesses anxiolytic-like effects in mice.