bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post–spinal cord injury astrocyte-mediated functional recovery in rats after intraspinal injection of the recombinant adenoviral vectors Ad5-VEGF and Ad5-ANG
Authors: Povysheva Tatyana , Shmarov Maksim , Logunov Denis , Naroditsky Boris , Shulman Ilya , Ogurcov Sergey , Kolesnikov Pavel , Islamov Rustem , Chelyshev Yuri 
Published: April 2017

OBJECTIVEThe most actively explored therapeutic strategy for overcoming spinal cord injury (SCI) is the delivery of genes encoding molecules that stimulate regeneration. In a mouse model of amyotrophic lateral sclerosis and in preliminary clinical trials in patients with amyotrophic lateral sclerosis, the combined administration of recombinant adenoviral vectors (Ad5-VEGF+Ad5-ANG) encoding the neurotrophic/angiogenic factors vascular endothelial growth factor (VEGF) and angiogenin (ANG) was found to slow the development of neurological deficits. These results suggest that there may be positive effects of this combination of genes in posttraumatic spinal cord regeneration. The objective of the present study was to determine the effects of Ad5-VEGF+Ad5-ANG combination therapy on motor function recovery and reactivity of astrocytes in a rat model of SCI.METHODSSpinal cord injury was induced in adult Wistar rats by the weight-drop method. Rats (n = 51) were divided into 2 groups: the experimental group (Ad5-VEGF+Ad5-ANG) and the control group (Ad5-GFP [green fluorescent protein]). Recovery of motor function was assessed using the Basso, Beattie, and Bresnahan scale. The duration and intensity of infectivity and gene expression from the injected vectors were assessed by immunofluorescent detection of GFP. Reactivity of glial cells was assessed by changes in the number of immunopositive cells expressing glial fibrillary acidic protein (GFAP), S100β, aquaporin 4 (AQP4), oligodendrocyte transcription factor 2, and chondroitin sulfate proteoglycan 4. The level of S100β mRNA expression in the spinal cord was estimated by real-time polymerase chain reaction.RESULTSPartial recovery of motor function was observed 30 days after surgery in both groups. However, Basso, Beattie, and Bresnahan scores were 35.9% higher in the Ad5-VEGF+Ad5-ANG group compared with the control group. Specific GFP signal was observed at distances of up to 5 mm in the rostral and caudal directions from the points of injection. A 1.5 to 2.0–fold increase in the number of GFAP+, S100β+, and AQP4+ cells was observed in the white and gray matter at a distance of up to 5 mm from the center of the lesion site in the caudal and rostral directions. At 30 days after injury, a 2-fold increase in S100β transcripts was observed in the Ad5-VEGF+Ad5-ANG group compared with the control group.CONCLUSIONSIntraspinal injection of recombinant adenoviral vectors encoding VEGF and ANG stimulates functional recovery after traumatic SCI. The increased number of S100β+ astrocytes induced by this approach may be a beneficial factor for maintaining the survival and function of neurons. Therefore, gene therapy with Ad5-VEGF+Ad5-ANG vectors is an effective therapeutic method for SCI treatment.
Survival after Metastasectomy for Metastatic Urothelial Carcinoma: A Systematic Review and Meta-Analysis
Authors: Patel Vaibhav , Collazo Lorduy Ana , Stern Aaron , Fahmy Omar , Pinotti Rachel , Galsky Matthew D. , Gakis Georgios 
Published: April 2017

Background: Cisplatin-based combination chemotherapy is standard treatment for metastatic urothelial carcinoma; however, the vast majority of patients experience disease progression. As systemic therapy alone is rarely curative for the treatment of metastatic urothelial cancer, not only are new therapies needed but also refinement of general treatment principles. Herein, we conducted a systematic review and meta-analysis to explore the role of metastasectomy in metastatic urothelial carcinoma. Methods: We conducted a systematic review of the literature regarding local treatment for metastatic urothelial carcinoma. An online electronic search of the PubMed/MEDLINE and EMBASE databases was performed to identify peer-reviewed articles. All procedures were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Information was then extracted including number of patients, gender, the site of the primary urothelial tumor, site of metastasis, chemotherapy before or after metastasectomy, overall survival (OS), and disease specific survival (DSS) after metastasectomy. A meta-analysis was performed with those studies with sufficient survival data to obtain pooled overall survival. The article quality was assessed using the Cochrane Handbook “risk of bias” tool. Results: Seventeen out of 3963 articles were eligible for review between 1990–2015, including a total of 412 patients. The mean time to recurrence after metastasectomy was 14.25 months. The overall survival from time of metastasectomy ranged from 2 to 60 months. Pooled analyses of studies reported survival data revealed an improved overall survival for patients treated with metastasectomy compared with non-surgical treatment of metastatic lesions (HR 0.63; 95% CI, 0.49–0.81). All, except for three studies, were retrospective and non-randomized, leading to a high risk of bias associated with patient selection, patient attrition, and reporting. Such high potential of selection bias may lead to higher OS than expected. Additionally, treatment and outcome details reported across studies was highly variable. Conclusions: Limited conclusions can be drawn from the available literature exploring the role of metastasectomy in the management of metastatic urothelial cancer due to lack of uniform reporting elements and multiple sources of bias particularly related to a lack of prospective randomized trials. As a subset of patients treated with metastasectomy achieve durable disease control, this approach may be considered for select patients.
Automatically finding execution scenarios to deploy security-sensitive workflows
Authors: dos Santos Daniel Ricardo , Ranise Silvio , Compagna Luca , Ponta Serena Elisa 
Published: April 2017

We introduce a new class of analysis problems, called Scenario Finding Problems (SFPs), for security-sensitive business processes that – besides execution constraints on tasks – define access control policies (constraining which users can execute which tasks) and authorization constraints (such as Separation of Duty). The solutions to SFPs are concrete execution scenarios that assist customers in the reuse and deployment of security-sensitive workflows. We study the relationship of SFPs to well-known properties of security-sensitive processes such as Workflow Satisfiability and Resiliency together with their complexity. Finally, we present a symbolic approach to solving SFPs and describe our experience with a prototype implementation on real-world business process models taken from an on-line library.
Data Requirements for the Correct Identification of Medication Errors and Adverse Drug Events in Patients Presenting at an Emergency Department
Authors: Plank-Kiegele Bettina , Bürkle Thomas , Müller Fabian , Patapovas Andrius , Sonst Anja , Pfistermeister Barbara , Dormann Harald , Maas Renke 
Published: April 2017

Summary
Background: Adverse drug events (ADE) involving or not involving medication errors (ME) are common, but frequently remain undetected as such. Presently, the majority of available clinical decision support systems (CDSS) relies mostly on coded medication data for the generation of drug alerts. It was the aim of our study to identify the key types of data required for the adequate detection and classification of adverse drug events (ADE) and medication errors (ME) in patients presenting at an emergency department (ED).
Methods: As part of a prospective study, ADE and ME were identified in 1510 patients presenting at the ED of an university teaching hospital by an interdisciplinary panel of specialists in emergency medicine, clinical pharmacology and pharmacy. For each ADE and ME the required different clinical data sources (i.e. information items such as acute clinical symptoms, underlying diseases, laboratory values or ECG) for the detection and correct classification were evaluated.
Results: Of all 739 ADE identified 387 (52.4%), 298 (40.3%), 54 (7.3%), respectively, required one, two, or three, more information items to be detected and correctly classified. Only 68 (10.2%) of the ME were simple drug-drug interactions that could be identified based on medication data alone while 381 (57.5%), 181 (27.3%) and 33 (5.0%) of the ME required one, two or three additional information items, respectively, for detection and clinical classification.
Conclusions: Only 10% of all ME observed in emergency patients could be identified on the basis of medication data alone. Focusing electronic decisions support on more easily available drug data alone may lead to an under-detection of clinically relevant ADE and ME.
Distance to the Low-velocity Cloud in the Direction of the High-velocity Compact Cloud CO–0.40–0.22
Authors: Iwata Yuhei , Kato Haruka , Sakai Daisuke , Oka Tomoharu 
Published: April 2017

Abstract
CO–0.40–0.22 is a peculiar molecular cloud that is compact and has an extraordinary broad velocity width. It is found in the central molecular zone (CMZ) of our Galaxy. In this direction, there is another cloud with an H2O maser spot at a lower velocity. A collision with this low-velocity cloud could be responsible for the broad velocity width of CO–0.40–0.22. We performed phase-referencing very long baseline interferometry (VLBI) astrometry with VERA and detected the annual parallax of the H2O maser spot in the low-velocity cloud to be 0.33 ± 0.14 mas, which corresponds to a distance of

from the Sun. This implies that the low-velocity cloud is located in the Galactic disk on the near side of the CMZ.
Factors Supporting an Information Technology Management : Teachers in Primary Schools in Thailand
Authors: Raso Daoprakai , Tungkunanan Pariyaporn , Anukulwech Abhichat 
Published: April 2017

The objectives of this research were (1) to study the authentic situation of the Information Technology Management of Teachers in Primary Schools in Thailand (2) to study the factors supporting the Information Technology Management of Teachers in Primary Schools in Thailand .
The sample group consisted of 165 teachers, teaching in primary schools under the office of the basic education commission (OBEC) in Thailand in 2016. By using multi-stage sampling technique. Data were collected by using questionnaire include 101 questions from 6 factors in which the questionnaires were approved content validity from experts at level of 0.95 and 0.97, respectively. The statistics were used to analyse the data as follows: mean (M), standard deviation (S.D),and Stepwise Multiple Regression Analysis. The study revealed that (1) the authentic situation of the Information Technology Management was found at “very often” level for the operation of the information technology management x ̅ = 4.09 and S.D.= 0.47 and (2) the factors that support the Information Technology Management consisting of the hardware factors and the people factor. The percentage was 28.80 and 32.70 consecutively, and shown the raw score and standard score was found from this formula Ý = 1.989 + .322(X1) + .178(X6) Ź = .363(X1) + .262(X6).
Cost-minimization Analysis of the Management of Acute Achilles Tendon Rupture
Authors: Truntzer Jeremy N. , Triana Brian , Harris Alex H. S. , Baker Laurence , Chou Loretta , Kamal Robin N. 
Published: April 2017

Background:Outcomes of nonsurgical management of acute Achilles tendon rupture have been demonstrated to be noninferior to those of surgical management. We performed a cost-minimization analysis of surgical and nonsurgical management of acute Achilles tendon rupture.Methods:We used a claims database to identify patients who underwent surgical (n = 1,979) and nonsurgical (n = 3,065) management of acute Achilles tendon rupture and compared overall costs of treatment (surgical procedure, follow-up care, physical therapy, and management of complications). Complication rates were also calculated. Patients were followed for 1 year after injury.Results:Average treatment costs in the year after initial diagnosis were higher for patients who underwent initial surgical treatment than for patients who underwent nonsurgical treatment ($4,292 for surgical treatment versus $2,432 for nonsurgical treatment;P< 0.001). However, surgical treatment required fewer office visits (4.52 versus 10.98;P< 0.001) and less spending on physical therapy ($595 versus $928;P< 0.001). Rates of rerupture requiring subsequent treatment (2.1% versus 2.4%;P= 0.34) and additional costs ($2,950 versus $2,515;P= 0.34) were not significantly different regardless whether initial treatment was surgical or nonsurgical. In both cohorts, management of complications contributed to approximately 5% of the total cost.Conclusion:From the payer’s perspective, the overall costs of nonsurgical management of acute Achilles tendon rupture were significantly lower than the overall costs of surgical management.Level of Evidence:III, Economic Decision Analysis
Reviewer Acknowledgements for Sustainable Agriculture Research, Vol. 6, No. 2
Authors: Lee Joan 
Published: April 2017

Sustainable Agriculture Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.Sustainable Agriculture Research is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please find the application form and details at http://www.ccsenet.org/reviewer and e-mail the completed application form to sar@ccsenet.org. Reviewers for Volume 6, Number 2Aftab Alam, Vice President Agriculture (R&D), Edenworks Inc. New York, United StatesAhmed Ghannam, University of Strasbourg, FranceAnchal Dass, Indian Agricultural Research Institute (IARI), IndiaBed Mani Dahal, Kathmandu University, NepalBernard Palmer Kfuban Yerima, University of Dschang, CameroonBeye Amadou Moustapha, Rice Research Center, Cote d'IvoireDariusz Kulus, University of Technology and Life Sciences, PolandGunnar Bengtsson, SwedenInder Pal Singh, Guru Angad Dev Veterinary and Animal Science University (GADVASU), IndiaJoanna Henryks, University of Canberra, AustraliaJose Antonio Alburquerque, Spanish National Research Council (CEBAS-CSIC), SpainJunjie Xu, University of Texas Southwestern Medical Center, United StatesKatarzyna Panasiewicz, Pozna? University of Life Sciences, Department of Agronomy, PolandManuel Teles Oliveira, University Tras os Montes Alto Douro (UTAD), PortugalMohammad Valipour, Payame Noor University, IranRam Niwas, District Institute of Rural Development, IndiaShengfei Zhou, University of Wisconsin-Madison, United StatesSilviu Beciu, University of Agronomic Sciences and Veterinary Medicine Bucharest, RomaniaStefano Marino, University of Molise, ItalyVishwambhar Prasad Sati, Government KRG Post Graduate College, India
Atmospheric, radiative, and hydrologic effects of future land use and land cover changes: A global and multimodel climate picture
Authors: Quesada Benjamin , Arneth Almut , de Noblet‐Ducoudré Nathalie 
Published: April 2017

AbstractLand use and land cover changes (LULCC) modulate land surface energy, heat, moisture, and momentum fluxes. Using simulations performed with and without LULCC for five earth system models, averaged over the 2071–2100 period, we quantify the biophysical effects in response to a future realistic LULCC scenario (Representative Concentration Pathway RCP8.5) on 15 climate variables (i.e., atmospheric, radiative, wind, hydrologic variables, and heat fluxes). We find that climate models are able to simulate some robust and strong climate perturbations in response to LULCC. In tropical regions with substantial LULCC, significantly higher skin temperatures, less precipitation and soil moisture, less evaporation and clouds, more incoming radiation and stronger winds, more anticyclonic conditions and subsidence, are simulated in response to future LULCC. In midlatitude and high latitude, LULCC result in autumn cooling and higher tropospheric pressures, while East Asia is drier, warmer, with higher sensible heat flux and lower evaporation. The tropical wind strengthening and weakening of the hydrological cycle are comparable in magnitude to their future regional changes induced by greenhouse gases under RCP8.5, which make LULCC an indispensable forcing to take into account in future climatic assessments. Finally, our study reveals significant indirect atmospheric processes triggered by LULCC, implying substantial changes in incoming radiation, which dominate climatic responses over the direct effects, particularly in boreal regions.
Multimodel precipitation responses to removal of U.S. sulfur dioxide emissions
Authors: Westervelt D. M. , Conley A. J. , Fiore A. M. , Lamarque J.‐F. , Shindell D. , Previdi M. , Faluvegi G. , Correa G. , Horowitz L. W. 
Published: April 2017

AbstractEmissions of aerosols and their precursors are declining due to policies enacted to protect human health, yet we currently lack a full understanding of the magnitude, spatiotemporal pattern, statistical significance, and physical mechanisms of precipitation responses to aerosol reductions. We quantify the global and regional precipitation responses to U.S. SO2 emission reductions using three fully coupled chemistry‐climate models: Community Earth System Model version 1, Geophysical Fluid Dynamics Laboratory Coupled Model 3, and Goddard Institute for Space Studies ModelE2. We contrast 200 year (or longer) simulations in which anthropogenic U.S. sulfur dioxide (SO2) emissions are set to zero with present‐day control simulations to assess the aerosol, cloud, and precipitation response to U.S. SO2 reductions. In all three models, reductions in aerosol optical depth up to 70% and cloud droplet number column concentration up to 60% occur over the eastern U.S. and extend over the Atlantic Ocean. Precipitation responses occur both locally and remotely, with the models consistently showing an increase in most regions considered. We find a northward shift of the tropical rain belt location of up to 0.35° latitude especially near the Sahel, where the rainy season length and intensity are significantly enhanced in two of the three models. This enhancement is the result of greater warming in the Northern versus Southern Hemispheres, which acts to shift the Intertropical Convergence Zone northward, delivering additional wet season rainfall to the Sahel. Two of our three models thus imply a previously unconsidered benefit of continued U.S. SO2 reductions for Sahel precipitation.
Die Biosynthese der β‐Lacton‐haltigen Proteasominhibitoren Belactosin und Cystargolid
Authors: Wolf Felix , Bauer Judith S. , Bendel Theresa M. , Kulik Andreas , Kalinowski Jörn , Gross Harald , Kaysser Leonard 
Published: April 2017

AbstractBelactosine und Cystargolide sind von Actinobakterien produzierte Naturstoffe mit proteasominhibitorischen Eigenschaften. Beide weisen ein Peptidrückgrat aus zwei Aminosäuren sowie einen einzigartigen β‐Lacton‐Baustein auf. Hier wird eine detaillierte Untersuchung der Biosynthese der beiden Naturstoffe beschrieben. Die Identifizierung und Analyse der entsprechenden Gencluster weist darauf hin, dass beide Stoffe über seltene Aminosäure‐Ligasen gebildet werden. Fütterungsversuche mit isotopenmarkierten Vorstufen und In‐vitro‐Biochemie zeigen einen bislang unbeschriebenen Mechanismus zur β‐Lacton‐Biosynthese, der sich aus der Leucin‐Bildung ableitet und die Beteiligung eines Isopropylmalat‐Synthase‐ähnlichen Enzyms vorsieht.
The Effect of Surface Site Ensembles on the Activity and Selectivity of Ethanol Electrooxidation by Octahedral PtNiRh Nanoparticles
Authors: Erini Nina , Beermann Vera , Gocyla Martin , Gliech Manuel , Heggen Marc , Dunin‐Borkowski Rafal E. , Strasser Peter 
Published: April 2017

AbstractDirect ethanol fuel cells are attractive power sources based on a biorenewable, high energy‐density fuel. Their efficiency is limited by the lack of active anode materials which catalyze the breaking of the C−C bond coupled to the 12‐electron oxidation to CO2. We report shape‐controlled PtNiRh octahedral ethanol oxidation electrocatalysts with excellent activity and previously unachieved low onset potentials as low as 0.1 V vs. RHE, while being highly selective to complete oxidation to CO2. Our comprehensive characterization and in situ electrochemical ATR studies suggest that the formation of a ternary surface site ensemble around the octahedral Pt3Ni1Rhx nanoparticles plays a crucial mechanistic role for this behavior.
The Structure of the Elusive Simplest Dipeptide Gly‐Gly
Authors: Cabezas Carlos , Varela Marcelino , Alonso José L. 
Published: April 2017

AbstractAmong the hundreds of peptide compounds for which conformations have been determined by using different spectroscopic techniques, the structure of the simplest dipeptide glycylglycine (Gly‐Gly) is conspicuously absent. Herein, for the first time, solid samples of Gly‐Gly have been vaporized by laser ablation and three different structures have been revealed in a supersonic expansion by Fourier transform microwave spectroscopy. The intramolecular hydrogen bonding interactions that stabilize the observed forms have been established based on the 14N nuclear quadrupole hyperfine structure. We have illustrated how conformer interconversion distorts the equilibrium conformational distribution, giving rise to missing conformers in the conformational landscape.
Partial Reduction and Selective Transfer of Hydrogen Chloride on Catalytic Gold Nanoparticles
Authors: Oliver‐Meseguer Judit , Doménech‐Carbó Antonio , Boronat Mercedes , Leyva‐Pérez Antonio , Corma Avelino 
Published: April 2017

AbstractHCl in solution accepts electron density from Au NPs and partially reduces at room temperature, as occurs with other simple diatomic molecules, such as O2 and H2. The activation can be run catalytically in the presence of alkynes to give exclusively E‐vinyl chlorides, after the regio‐ and stereoselective transfer of HCl. Based also on this method, vinyl chloride monomer (VCM) can be produced in a milder and greener way than current industrial processes.
Reversible Supracolloidal Self‐Assembly of Cobalt Nanoparticles to Hollow Capsids and Their Superstructures
Authors: Nonappa  , Haataja Johannes S. , Timonen Jaakko V. I. , Malola Sami , Engelhardt Peter , Houbenov Nikolay , Lahtinen Manu , Häkkinen Hannu , Ikkala Olli 
Published: April 2017

AbstractThe synthesis and spontaneous, reversible supracolloidal hydrogen bond‐driven self‐assembly of cobalt nanoparticles (CoNPs) into hollow shell‐like capsids and their directed assembly to higher order superstructures is presented. CoNPs and capsids form in one step upon mixing dicobalt octacarbonyl (Co2CO8) and p‐aminobenzoic acid (pABA) in 1,2‐dichlorobenzene using heating‐up synthesis without additional catalysts or stabilizers. This leads to pABA capped CoNPs (core ca. 5 nm) with a narrow size distribution. They spontaneously assemble into tunable spherical capsids (d≈50–200 nm) with a few‐layered shells, as driven by inter‐nanoparticle hydrogen bonds thus warranting supracolloidal self‐assembly. The capsids can be reversibly disassembled and reassembled by controlling the hydrogen bonds upon heating or solvent exchanges. The superparamagnetic nature of CoNPs allows magnetic‐field‐directed self‐assembly of capsids to capsid chains due to an interplay of induced dipoles and inter‐capsid hydrogen bonds. Finally, self‐assembly on air–water interface furnishes lightweight colloidal framework films.