bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salmonella enteritidis primary bacteremia in previously healthy patient from Taiwan: case report
Authors: Mileva Sevda , Gospodinova Margarita , Todorov Ilian 
Published: August 2016

Background: Diseases caused by invasive nontyphoidal Salmonella strains present with various extraintestinal manifestations, including bacteremia. Factors affecting the incidence include Salmonella serotype, geographic location, and host factors. Case: We present an unusual case of Salmonella enteritidis primary bacteremia in a patient without any risk factors and originating from a region with the lowest burden of invasive nontyphoidal Salmonella infections. We observed an incomplete clinical response to the treatment with a third-generation cephalosporin, despite the in vitro susceptibility of the strain. Discussion: The diagnosis of Salmonella bacteremia was far from expected in our previously healthy patient from Taiwan, without any preceding diarrhea and the lack of marked response to therapy with ceftriaxone. Making the diagnosis was a challenge, requiring wide range of laboratory, imaging, and consultative work to rule out alternative diagnoses and complications. Conclusion: Invasive Salmonella infections are uncommon in our clinical practice at the present. Air transportation, intensive migration processes, and changes in climate are able to change the burden of infectious diseases dramatically in the near future. That fact along with the raising antibacterial resistance among invasive nontyphoidal Salmonella strains make imperative the profound understanding of the epidemiology and pathophysiology of those infections.
Fine-grained parallelization of fitness functions in bioinformatics optimization problems: gene selection for cancer classification and biclustering of gene expression data
Authors: Gomez-Pulido Juan A. , Cerrada-Barrios Jose L. , Trinidad-Amado Sebastian , Lanza-Gutierrez Jose M. , Fernandez-Diaz Ramon A. , Crawford Broderick , Soto Ricardo 
Published: September 2016

Abstract
Background
Metaheuristics are widely used to solve large combinatorial optimization problems in bioinformatics because of the huge set of possible solutions. Two representative problems are gene selection for cancer classification and biclustering of gene expression data. In most cases, these metaheuristics, as well as other non-linear techniques, apply a fitness function to each possible solution with a size-limited population, and that step involves higher latencies than other parts of the algorithms, which is the reason why the execution time of the applications will mainly depend on the execution time of the fitness function. In addition, it is usual to find floating-point arithmetic formulations for the fitness functions. This way, a careful parallelization of these functions using the reconfigurable hardware technology will accelerate the computation, specially if they are applied in parallel to several solutions of the population.

Results
A fine-grained parallelization of two floating-point fitness functions of different complexities and features involved in biclustering of gene expression data and gene selection for cancer classification allowed for obtaining higher speedups and power-reduced computation with regard to usual microprocessors.

Conclusions
The results show better performances using reconfigurable hardware technology instead of usual microprocessors, in computing time and power consumption terms, not only because of the parallelization of the arithmetic operations, but also thanks to the concurrent fitness evaluation for several individuals of the population in the metaheuristic. This is a good basis for building accelerated and low-energy solutions for intensive computing scenarios.
Communicating Value in Health Care Using Radar Charts: A Case Study of Prostate Cancer
Authors: Thaker Nikhil G. , Ali Tariq N. , Porter Michael E. , Feeley Thomas W. , Kaplan Robert S. , Frank Steven J. 
Published: August 2016

Purpose: The transformation from volume to value will require communication of outcomes and costs of therapies; however, outcomes are usually nonstandardized, and cost of therapy differs among stakeholders. We developed a standardized value framework by using radar charts to visualize and communicate a wide range of patient outcomes and cost for three forms of prostate cancer treatment. Materials and Methods: We retrospectively reviewed data from men with low-risk prostate cancer who were treated with low-dose rate brachytherapy (LDR-BT), proton beam therapy, or robotic-assisted prostatectomy. Patient-reported outcomes comprised the Expanded Prostate Cancer Index Composite-50 domains for sexual function, urinary incontinence and/or bother, bowel bother, and vitality 12 months after treatment. Costs were measured by time-driven activity-based costing for the first 12 months of the care cycle. Outcome and cost data were plotted on a single radar chart for each treatment modality. Results: Outcome and cost data from patients who were treated with robotic-assisted prostatectomy (n = 381), proton beam therapy (n = 165), and LDR-BT (n = 238) were incorporated into the radar chart. LDR-BT seemed to deliver the highest overall value of the three treatment modalities; however, incorporation of patient preferences regarding outcomes may allow other modalities to be considered high-value treatment options. Conclusion: Standardization and visualization of outcome and cost metrics may allow more comprehensive and collaborative discussions about the value of health care services. Communicating the value framework by using radar charts may be an effective method to present total value and the value of all outcomes and costs in a manner that is accessible to all stakeholders. Variations in plotting of costs and outcomes will require future focus group initiatives.
Atg9A trafficking through the recycling endosomes is required for autophagosome formation
Authors: Imai Kenta , Hao Feike , Fujita Naonobu , Tsuji Yasuhiro , Oe Yukako , Araki Yasuhiro , Hamasaki Maho , Noda Takeshi , Yoshimori Tamotsu 
Published: September 2016

ABSTRACT
Autophagy is an intracellular degradation pathway conserved in eukaryotes. Among core autophagy-related (Atg) proteins, mammalian Atg9A is the sole multi-spanning transmembrane protein, and both of its N- and C-terminal domains are exposed to the cytoplasm. It is known that Atg9A travels through the trans-Golgi network (TGN) and the endosomal system under nutrient-rich conditions, and transiently localizes to the autophagosome upon autophagy induction. However, the significance of Atg9A trafficking for autophagosome formation remains elusive. Here, we identified sorting motifs in the N-terminal cytosolic stretch of Atg9A that interact with the adaptor protein AP-2. Atg9A with mutations in the sorting motifs could not execute autophagy and was abnormally accumulated at the recycling endosomes. The combination of defects in autophagy and Atg9A accumulation in the recycling endosomes was also found upon the knockdown of TRAPPC8, a specific subunit of the TRAPPIII complex. These results show directly that the trafficking of Atg9A through the recycling endosomes is an essential step for autophagosome formation.
A rare case of septic thrombosis in the inferior vena cava with embolism
Authors: Burkert B. , Majewski H. , Mühlberger D. , Mumme A. , Hummel T. , Regeniter Ph. 
Published: September 2016

SummaryThis paper presents the case of a 61-year-old female patient who complained about exhaustion and fever during curative therapy, a few weeks after hysterectomie and adnexectomy. Antibiotic therapy could only improve these symptoms though only in the short term. Additionally, a venous port, which had been implanted for the purpose of cytoreduction chemotherapy, was suspected of a catheter infection and was removed. However, this did not lead to a substantial improvement of the patient’s general state of health, but ultimately triggered a sepsis, making necessary treatment in intensive care unit. At this stage, the detailed search for the focus of the infection led to the discovery of an infected thrombosis of the inferior vena cava with bilateral septic pulmonal embolisms and with an abscess. Thus, the source of sepsis had to be removed by surgery, a transfemoral thrombectomy was performed and an inguinal arteriovenous fistula was created. The further course of the disease was without complications; the patient could be released into ambulant treatment 24 days after the surgery. The elective sealing of the arteriovenous fistula was carried out 11 months later. In the follow- up, there were no hints for infection; the deep venous system in particular did not indicate any new thrombosis or of residual thrombi, with the tumor follow-up-care showing a complete remission.
An Econometric Study of the Hardwood Sawtimber Stumpage Market in Louisiana
Authors: Parajuli Rajan , Zhang Daowei 
Published: August 2016

Abstract
Although the hardwood timber market is an important segment of the forest industry in the United States, little attention has been paid to modeling hardwood stumpage and lumber markets. Based on the annual data series from 1955 to 2014, we estimate simultaneous demand and supply models of the hardwood sawtimber stumpage market in Louisiana. A permanent structural break in 1993 is detected in the hardwood sawtimber stumpage market, and the modified cointegration test and structural vector error correction approach are used to estimate the demand for and supply of hardwood sawtimber stumpage. The results show that own-price elasticity values in both the demand and the supply equations are inelastic in the long run. Hardwood and softwood sawtimber are found to be substitutes. Moreover, the softwood timber market always leads in the feedback adjustment process and can help predict the hardwood timber price in Louisiana.
COGNIÇÃO E AFETIVIDADE NAS TRAJETÓRIAS EMPREENDEDORAS DAS MULHERES DA CIDADE DO NATAL – RN
Authors: Cortez Ana Eliza Galvão , Ferreira Thaís Barbosa , Ferreira Cristiane de Melo , Araújo Afrânio Galdino 
Published: September 2016

Este estudo tem como objetivo geral compreender a influência dos aspectos cognitivos e afetivos nas trajetórias de mulheres empreendedoras na cidade do Natal – Rio Grande do Norte. Norteia-se pelo framework proposto por Nassif, Ghobril e Silva (2010), que considera a dinamicidade do processo empreendedor ao contemplar fatores como características pessoais, sociológicas e ambientais e as diferentes fases pelas quais passa uma organização. Julgou-se oportuno a realização de um estudo qualitativo e para viabilizar a consecução dos objetivos, utilizou-se o método da história oral temática. A pesquisa foi desenvolvida com dez mulheres empreendedoras da cidade do Natal - RN, que estão à frente de empreendimentos de três anos e meio a 30 anos de existência. A coleta dos dados foi realizada por meio de entrevista semiestruturada, que foi transcrita e analisada utilizando a análise de conteúdo. Os resultados apontam que os aspectos afetivos têm significativa e constante relevância nas ações das empreendedoras em todas as fases de seus empreendimentos e que os aspectos cognitivos se tornam mais influentes à medida que os empreendimentos crescem e se desenvolvem no decorrer da trajetória empreendedora.
Geschichte und Verantwortung
Authors: Langer Robert 
Published: September 2016

Zusammenfassung
Die Stadtbibliothek Bautzen untersucht als erste öffentliche Bibliothek ihre Bestände im Sachgebiet Altbestand/Regionalkunde (ehemalige wissenschaftliche Abteilung) systematisch auf Bücher, die während der Zeit des Nationalsozialismus unrechtmäßig in ihren Besitz gelangten. Dabei erwächst ihr aus der eigenen Institutionsgeschichte eine Verantwortung, die mit dem Fortschreiten des NS-Raubgutprojektes und den ersten Restitutionen deutlich zu Tage tritt.
The standard sign conjecture on algebraic cycles: The case of Shimura varieties
Authors: Morel Sophie , Suh Junecue 
Published: September 2016

Abstract
We show how to deduce the standard sign conjecture (a weakening of the Künneth standard conjecture) for Shimura varieties from some statements
about discrete automorphic representations (Arthur’s conjectures plus a bit more).
We also indicate what is known (to us) about these statements.
Anti-adenovirus activity, antioxidant potential, and phenolic content of black tea (Camellia sinensis Kuntze) extract
Authors: Karimi Ali , Moradi Mohammad-Taghi , Alidadi Somayeh , Hashemi Leila 
Published: August 2016

Abstract

Background
Adenovirus (ADV) causes a number of diseases in human, and to date, no specific antiviral therapy is approved against this virus. Thus, searching for effective anti-ADV agents seems to be an urgent requirement. Many studies have shown that components derived from medicinal plants have antiviral activity. Therefore, the present study was aimed to evaluate in vitro anti-ADV activity and also antioxidant potential and total phenolic compounds of black tea (Camellia sinensis) crude extract.

Methods
In this study, the hydroalchoholic extract of black tea was prepared and its anti-ADV activity was evaluated on HEp2 cell line using MTT [3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide] assay. The 50 % inhibitory concentration (IC50) and 50 % cytotoxicity concentration (CC50) of the extract were determined using regression analysis. Its inhibitory effect on adsorption and/or post-adsorption stages of the virus replication cycle was evaluated. To determine antioxidant activity, total phenol content, and flavonoids content of the extract, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, Folin–Ciocalteu method, and aluminum chloride colorimetric method were used, respectively.

Results
The CC50 and the IC50 of the extract were 165.95±12.7 and 6.62±1.4 µg/mL, respectively, with the selectivity index (SI) of 25.06. This extract inhibited ADV replication in post-adsorption stage. The IC50 of DPPH radical was 8±1.41 μg/mL, compared with butylated hydroxytoluene, with IC50 of 25.41±1.89 μg/mL. The total phenol and flavonoid contents of the extract were 341.8±4.41 mg gallic acid equivalent per gram and 21.1±2.11 mg/g, respectively.

Conclusions
Having SI value of 25.06 with inhibitory effect on ADV replication, particularly during the post-adsorption period, black tea extract could be considered as a potential anti-ADV agent. The antiviral activity of this extract could be attributed to its phenolic compounds.
A Systems-Of-Systems Conceptual Model and Live Virtual Constructive Simulation Framework for Improved Nuclear Disaster Emergency Preparedness, Response, and Mitigation
Authors: Davis Matthew , Proctor Michael , Shageer Buder 
Published: August 2016

Abstract
Nuclear disasters have severe and far-reaching consequences. Emergency managers and first responders from utility owners to local, state, and federal civil authorities and the Department of Defense (DoD) must be well prepared in order to rapidly mitigate the disaster and protect the public and environment from spreading damage. Given the high risks, modeling and simulation (M&S) plays a significant role in planning and training for the spectrum of derivate scenarios. Existing reactor models are largely legacy, stove-piped designs lacking interoperability between themselves and other M&S tools for emergency preparedness system evaluation and training. Unmanned systems present a growing area of technology promising significant improvement in response and mitigation. To bridge the gap between current and future models, we propose a conceptual model (CM) for integrating live, virtual, and constructive (LVC) models with nuclear disaster and mitigation models utilizing a system-of-systems (SoS) approach. The CM offers to synergistically enhance current reactor and dispersion simulations with intervening avatar and agent simulations. The SoS approach advances life cycle stages including concept exploration, system design, engineering, training, and mission rehearsal. Component subsystems of the CM are described along with an explanation of input/output requirements. A notional implementation is described. Finally, applications to analysis and training, an evaluation of the CM based on recently proposed criteria found in the literature, and suggestions for future research are discussed.
Application of Taguchi Method for Optimization of Parameters in Turning Operation
Authors: Singaravel B. , Selvaraj T. 
Published: August 2016

AbstractCutting tool vibration analysis is the effective way to understand the machining characteristics of any material. In the present work, the effect of process parameters on cutting tool vibration is estimated using Taguchi method in turning of EN25 steel. Taguchi method uses Signal-to-Noise ratio (S/N) and Analysis of Variance (ANOVA) to determine the optimum level of process parameters and significant parameters. The results showed that cutting speed of 215 m/min, feed rate of 0.07 mm/rev and depth of cut of 0.5 mm are the optimum combination of process parameters. Cutting speed and depth of cut are the influencing parameters on cutting tool vibration. The results are experimentally verified and the results based on turning process response can be effectively improved.
Experimental Investigation of Multiple Quality Characteristics of Laser Beam Machined Surface using Integrated Taguchi and Fuzzy Logic Method
Authors: Kumar Anish , Kumar Vinod , Sharma Gaurav 
Published: August 2016

AbstractIn laser cutting, the capability of laser cutting mainly depends on optical and thermal properties of work material. The surface quality and metallurgical properties of the product is most important from the point of laser cutting quality. The present research work explores the modeling and optimization of laser beam cutting process parameters by using hybrid approach of Taguchi based fuzzy logic. The multi-response optimization of process parameters has been done to improve geometrical accuracy by minimizing the kerf width and kerf deviation. The four input parameters power, gas pressure, feed rate, pulse frequency and three output parameters kerf width (KW), kerf deviation (KD) and material removal rate (MRR) have been taken for the experimentation work. The S/N ratios taken for the KW and KD is of the smaller-the-better type and MRR is of the higher the better type. The predicting fuzzy logic model is implemented on Fuzzy Logic Toolbox of MATLAB using Mamdani technique. The fuzzy logic theory has been applied to compute the fuzzy multi-response performance index (FMRPI). This performance index is further used for multi-objective optimization. The selected samples were analyzed using scanning electron microscope. The predicted optimum results have been validated by performing the confirmation tests. The confirmation tests showed the considerable reduction in kerf deviation and increase in material removal rate.
A combined approximation for the traveling tournament problem and the traveling umpire problem
Authors: Bender Marco , Westphal Stephan 
Published: August 2016

AbstractWe consider the traveling tournament problem (TTP) and the traveling umpire problem (TUP). In TTP, the task is to design a double round-robin schedule, where no two teams play against each other in two consecutive rounds, and the total travel distance is minimized. In TUP, the task is to find an assignment of umpires for a given tournament such that every umpire handles at least one game at every team’s home venue and an umpire neither visits a venue nor sees a team (home or away) too often. The task is to minimize the total distance traveled by the umpires. We present a combined approximation for this problem, when the number of umpires is odd. We therefore first design an approximation algorithm for TTP and then show how to define an umpire assignment for this tournament such that a constant-factor approximation for TUP is guaranteed.
Binuclear trivalent and tetravalent uranium halides and cyanides supported by cyclooctatetraene ligands
Authors: Wang Cong-Zhi , Wu Qun-Yan , Lan Jian-Hui , Chai Zhi-Fang , Gibson John K. , Shi Wei-Qun 
Published: August 2016

AbstractAlthough the first organoactinide chloride Cp3UCl (Cp=η5-C5H5) was synthesized more than 50 years ago, binuclear uranium halides remain very rare in organoactinide chemistry. Herein, a series of binuclear trivalent and tetravalent uranium halides and cyanides with cyclooctatetraene ligands, (COT)2U2Xn(COT=η8-C8H8; X=F, Cl, CN;n=2, 4), have been systematically studied using scalar-relativistic density functional theory (DFT). The structures with bridging halide or cyanide ligands were predicted to be the most stable complexes of (COT)2U2Xn, and all the complexes show weak antiferromagnetic interactions between the uranium centers. However, for each species, there is no significant uranium-uranium bonding interaction. The bonding between the metal and the ligands shows some degree of covalent character, especially between the metal and terminal halide or cyanide ligands. The U-5f and 6d orbitals are predominantly involved in the metal-ligand bonding. All the (COT)2U2Xnspecies were predicted to be more stable compared to the mononuclear half-sandwich complexes at room temperature in the gas phase such that (COT)2U2X4might be accessible through the known (COT)2U complex. The tetravalent derivatives (COT)2U2X4are more energetically favorable than the trivalent (COT)2U2X2analogs, which may be attributed to the greater number of strong metal-ligand bonds in the former complexes.
Pipeline Power: A Case Study of Strategic Network Investments
Authors: Hubert Franz , Cobanli Onur 
Published: August 2016

AbstractWe analyze the impact of three controversial pipeline projects on the power structure in the Eurasian network for natural gas. Two pipelines, “Nord Stream” and “South Stream,” allow Russian gas to bypass transit countries, Ukraine and Belarus. The third project, “Nabucco,” aims at diversifying Europe’s gas imports by accessing producers in Middle East and Central Asia. If network power is measured with the Shapley Value we obtain a clear ranking of the projects which corresponds to the observed investment patterns. Nord Stream’s strategic value is huge, easily justifying the high investment cost for Germany and Russia. The additional leverage obtained through South Stream is much smaller and Nabucco is not viable. For the nucleolus in contrast, none of the pipelines has any strategic relevance at all, which contradicts the empirical evidence on investment.
Synthesis and characterization of two new chiral Kemp’s acid derivatives: structures fixed by a peculiar system of N–H···O, C–H···O and C–H···N hydrogen bonds
Authors: Pažout Richard , Maixner Jaroslav , Pecháček Jan , Vilhanová Beáta , Kačer Petr 
Published: August 2016

Abstract
New chiral imide-oxazoline derivatives of Kemp’s acid were synthesized with the aim to produce new ligands suitable for catalytic asymmetric reactions. Compound 1 is C18H28N2O3, systematic name (1R, 5S, 7R)-7-[(S)-4-tert-butyl-4,5-dihydrooxazole-2-yl]-1,5,7-trimethyl-3-azabicyclo-[3.3.1]-nonane-2,4-dione. Compound 2 is C21H26N2O3, systematic name (1R,5S,7R)-7-[(S)-4-benzyl-4,5-dihydrooxazole-2-yl]-1,5,7-trimethyl-3-azabicyclo-[3.3.1]-nonane-2,4-dione. Both compounds contain two molecules with very similar conformations in the asymmetric unit. The two structures were characterized by single crystal X-ray diffraction. DFT calculations of two possible distinct conformations were performed to elucidate the differences between the preferred conformation in vacuo and the one observed in the single crystal. Also, charges on the key atoms of the compounds were compared with a common ligand used for asymmetric transfer hydrogenation.
Crystalline chalcogenido metalates – synthetic approaches for materials synthesis and transformation
Authors: Thiele Günther , Santner Silke , Dehnen Stefanie 
Published: August 2016

Abstract
The formation and transformation of crystalline chalcogenido metalates in ionic liquids as solvents is discussed as a new synthetic approach for the generation of novel materials. A comparison to conventional solvothermal reactions, classical high-temperature syntheses and chemical solution based approaches in common is discussed.