bluuebunny/crossref_metadata_2025_split huggingface dataset:
SnO2@N‐Doped Carbon Hollow Nanoclusters for Advanced Lithium‐Ion Battery Anodes
Authors: Li Lu , Zhang Lingyu , Chai Fang , Wang Tingting , Li Zilu , Xie Haiming , Wang Chungang , Su Zhongmin 
Published: January 2016

AbstractA facile method to synthesize novel monodispersed SnO2@N‐doped carbon hollow nanoclusters as a high‐performance anode material for lithium‐ion batteries was explored. The uniqueness of this structure results from the large amount of ultrafine small SnO2 nanoparticles, the hollow interior space, and the continuous N‐doped carbon shells, which successfully buffer problems associated with huge volume changes and guarantee electrical connectivity. All of these features make the nanocomposite well fitted for lithium storage. As a result, the electrochemical performance of monodispersed SnO2@N‐doped carbon hollow nanoclusters as an anode in lithium‐ion batteries is significantly improved, as it shows high initial discharge and charge capacities of 1572 and 1003 mA h g–1, respectively. Importantly, nearly 100 % discharge/charge efficiency is maintained during 100 consecutive cycles with a specific capacity above 910 mA h g–1.
Enhanced Photocatalytic Hydrogen Production by Adsorption of an [FeFe]‐Hydrogenase Subunit Mimic on Self‐Assembled Membranes
Authors: Troppmann Stefan , Brandes Eva , Motschmann Hubert , Li Fei , Wang Mei , Sun Licheng , König Burkhard 
Published: January 2016

AbstractSelf‐assembled vesicles with membrane‐embedded or adsorbed ruthenium polypyridine complexes were further functionalized by the adsorption of an [FeFe]‐hydrogenase subunit mimic to the membrane interface enhancing the photocatalytic hydrogen production in water under acidic conditions. The resulting two‐dimensional membrane assembly places the photosensitizer and hydrogen‐evolving diiron complex in close proximity resulting in a six‐ to twelvefold increase in the turnover number as compared to the same system in the absence of lipid membranes. The interface assembly then enables the combining of hydrophilic and hydrophobic catalytic entities for light‐driven proton reduction in acidic water and provides a flexible method for membrane functionalization.
Enantioselective Reduction of Ethyl 3‐Oxo‐5‐phenylpentanoate with Whole‐Cell Biocatalysts
Authors: Zadlo Anna , Schrittwieser Joerg H. , Koszelewski Dominik , Kroutil Wolfgang , Ostaszewski Ryszard 
Published: January 2016

AbstractThe biocatalytic stereoselective synthesis of a sterically demanding sec‐alcohol (ethyl 3‐hydroxy‐5‐phenylpentanoate) was investigated by starting from the corresponding prochiral ketone. Screening of a collection of microorganisms led to the identification of stereocomplementary catalysts suitable for accessing both enantiomers of the target compound. Cofactors, recycling systems and 2‐propanol amounts were optimized for selected biocatalysts, leading to excellent enantiomeric excesses for the obtained hydroxy ester with up to 99 % ee. The utility of the identified strains was showcased by using preparative‐scale reactions.
Influence of Lithium on the Sintering Behavior and Electrical Properties of Ce0.8Gd0.2O1.9 for Intermediate‐Temperature Solid Oxide Fuel Cells
Authors: Accardo Grazia , Ferone Claudio , Cioffi Raffaele 
Published: January 2016

AbstractThe main purpose of this work is to verify the influence of the addition of lithium on the densification and electrical conductivity of a gadolinium‐doped ceria electrolyte. The lithium dopant was added directly during the sol–gel synthesis without a grinding step or the use of a dispersant solution. Electrolytes were prepared from powders and sintered at 1250 and 1500 °C. The characterization techniques used were XRD, FTIR spectroscopy, SEM, BET analysis, and electrochemical impedance spectroscopy for ionic conductivity. The densification achieved was >97 and >99 % of the theoretical density at sintering temperatures of 1250 and 1500 °C, respectively, by adding 2 mol % of lithium. The densification of gadolinium‐doped ceria is caused by lithium deposition in the grain boundaries, which reduces structural imperfections. The ionic conductivity of lithium‐doped pellets sintered at 1250 °C is the same as that of pure ones sintered at 1500 °C with a maximum value of 5.2×10−2 S cm−1 at 800 °C. Lithium addition is an effective strategy to reduce the sintering temperature and retain high conductivity values.
Organ-specific accumulation, transportation, and elimination of methylmercury and inorganic mercury in a low Hg accumulating fish
Authors: Peng Xiaoyan , Liu Fengjie , Wang Wen-Xiong 
Published: January 2016

Abstract

Low mercury (Hg) concentrations down to several nanograms Hg per gram of wet tissue are documented in certain fish species such as herbivorous fish, and the underlying mechanisms remain speculative. In the present study, bioaccumulation and depuration patterns of inorganic Hg(II) and methylmercury (MeHg) in a herbivorous rabbitfish Siganus canaliculatus were investigated at organ and subcellular levels following waterborne or dietary exposures. The results showed that the efflux rate constants of Hg(II) and MeHg were 0.104 d−1 and 0.024 d−1, respectively, and are probably the highest rate constants recorded in fish thus far. The dietary MeHg assimilation efficiency (68%) was much lower than those in other fish species (∼90%). The predominant distribution of MeHg in fish muscle was attributable to negligible elimination of MeHg from muscle (&lt; 0) and efficient elimination of MeHg from gills (0.12 d−1), liver (0.17 d−1), and intestine (0.20 d−1), as well as efficient transportation of MeHg from other organs into muscle. In contrast, Hg(II) was much more slowly distributed into muscle but was efficiently eliminated by the intestine (0.13 d−1). Subcellular distribution indicated that some specific membrane proteins in muscle were the primary binding pools for MeHg, and both metallothionein-like proteins and Hg-rich granules were the important components in eliminating both MeHg and Hg(II). Overall, the present study's results suggest that the low tissue Hg concentration in the rabbitfish was partly explained by its unique biokinetics. Environ Toxicol Chem 2016;35:2074–2083. © 2016 SETAC
Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson's disease with clinical and neuroimaging measures
Authors: Ye Zheng , Rae Charlotte L. , Nombela Cristina , Ham Timothy , Rittman Timothy , Jones Peter Simon , Rodríguez Patricia Vázquez , Coyle‐Gilchrist Ian , Regenthal Ralf , Altena Ellemarije , Housden Charlotte R. , Maxwell Helen , Sahakian Barbara J. , Barker Roger A. , Robbins Trevor W. , Rowe James B. 
Published: January 2016

AbstractRecent studies indicate that selective noradrenergic (atomoxetine) and serotonergic (citalopram) reuptake inhibitors may improve response inhibition in selected patients with Parkinson's disease, restoring behavioral performance and brain activity. We reassessed the behavioral efficacy of these drugs in a larger cohort and developed predictive models to identify patient responders. We used a double‐blind randomized three‐way crossover design to investigate stopping efficiency in 34 patients with idiopathic Parkinson's disease after 40 mg atomoxetine, 30 mg citalopram, or placebo. Diffusion‐weighted and functional imaging measured microstructural properties and regional brain activations, respectively. We confirmed that Parkinson's disease impairs response inhibition. Overall, drug effects on response inhibition varied substantially across patients at both behavioral and brain activity levels. We therefore built binary classifiers with leave‐one‐out cross‐validation (LOOCV) to predict patients’ responses in terms of improved stopping efficiency. We identified two optimal models: (1) a “clinical” model that predicted the response of an individual patient with 77–79% accuracy for atomoxetine and citalopram, using clinically available information including age, cognitive status, and levodopa equivalent dose, and a simple diffusion‐weighted imaging scan; and (2) a “mechanistic” model that explained the behavioral response with 85% accuracy for each drug, using drug‐induced changes of brain activations in the striatum and presupplementary motor area from functional imaging. These data support growing evidence for the role of noradrenaline and serotonin in inhibitory control. Although noradrenergic and serotonergic drugs have highly variable effects in patients with Parkinson's disease, the individual patient's response to each drug can be predicted using a pattern of clinical and neuroimaging features. Hum Brain Mapp 37:1026–1037, 2016. © 2016 Wiley Periodicals, Inc.
Response‐Scale Heterogeneity in the EQ‐5D
Authors: Knott Rachel J. , Black Nicole , Hollingsworth Bruce , Lorgelly Paula K. 
Published: January 2016

AbstractThis paper discusses two types of response‐scale heterogeneity, which may impact upon the EQ‐5D. Response‐scale heterogeneity in reporting occurs when individuals systematically differ in their use of response scales when responding to self‐assessments. This type of heterogeneity is widely observed in relation to other self‐assessed measures but is often overlooked with regard to the EQ‐5D. Analogous to this, preference elicitation involving the EQ‐5D could be subject to a similar type of heterogeneity, where variations across respondents may occur in the interpretations of the levels (response categories) being valued. This response‐scale heterogeneity in preference elicitation may differ from variations in preferences for health states, which have been observed in the literature. This paper explores what these forms of response‐scale heterogeneity may mean for the EQ‐5D and the potential implications for researchers who rely on the instrument as a measure of health and quality of life. We identify situations where they are likely to be problematic and present potential avenues for overcoming these issues. Copyright © 2016 John Wiley & Sons, Ltd.
Error distribution modelling of satellite soil moisture measurements for hydrological applications
Authors: Zhuo Lu , Dai Qiang , Islam Tanvir , Han Dawei 
Published: January 2016

AbstractSatellite‐based soil moisture data accuracies are of important concerns by hydrologists because they could significantly influence hydrological modelling uncertainty. Without proper quantification of their uncertainties, it is difficult to optimize the hydrological modelling system and make robust decisions. Currently, the satellite soil moisture data uncertainty has been limited to summary statistics with the validations mainly from the in situ measurements. This study attempts to build the first error distribution model with additional higher‐order uncertainty modelling for satellite soil moisture observations. The methodology is demonstrated by a case study using the Soil Moisture and Ocean Salinity satellite soil moisture observations. The validation is based on soil moisture estimates from hydrological modelling, which is more relevant to the intended data use than the in situ measurements. Four probability distributions have been explored to find suitable error distribution curves using the statistical tests and bootstrapping resampling technique. General extreme value is identified as the most suitable one among all the curves. The error distribution model is still in its infant stage, which ignores spatial and temporal correlations, and nonstationarity. Further improvements should be carried out by the hydrological community by expanding the methodology to a wide range of satellite soil moisture data using different hydrological models. Copyright © 2016 John Wiley & Sons, Ltd.
Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27‐hydroxycholesterol
Authors: Vini Ravindran , Juberiya Azeez M , Sreeja Sreeharshan 
Published: January 2016

AbstractThe direct relationship between obesity and breast cancer has been elucidated recently with the identification of a cholesterol derivative 27‐hydroxycholesterol (27HC), an endogenous SERM that can act through estrogen receptor (ER)‐mediated mechanisms. Our recent research shed light on the possible SERM‐like property of methanol extract of pericarp of pomegranate (PME) by using human breast (MCF‐7, MDA‐MB‐231), endometrial (HEC‐1A), cervical (SiHa, HeLa), ovarian (SKOV3) cancer cell lines, normal breast fibroblasts (MCF‐10A) and also by in vivo models (ovariectomized Swiss albino mice). Our findings demonstrated that PME binds to ER and downregulates the Estrogen response elements (ERE)‐mediated transcription in breast cancer cells without being agonistic in the uterine endometrium and has cardioprotective effects comparable to that of 17‐β‐estradiol. This preliminary work indicates the ability of PME to antagonize the activity of 27HC. We hypothesize that PME can compete with 27HC for ERα and reduce 27HC‐induced proliferation of MCF‐7 cells. Relevant estrogen‐regulated genes such as pS2, PR and ERα were checked to evaluate the ability of PME to abrogate 27HC‐induced genes. This study is significant, being the first report describing that bioactive components of the methanolic extract of pericarp of PME, a proven SERM could plausibly compete for 27HC. © 2016 IUBMB Life, 68(2):116–121, 2016
Breast cancer molecular subtype classifier that incorporates MRI features
Authors: Sutton Elizabeth J. , Dashevsky Brittany Z. , Oh Jung Hun , Veeraraghavan Harini , Apte Aditya P. , Thakur Sunitha B. , Morris Elizabeth A. , Deasy Joseph O. 
Published: January 2016

PurposeTo use features extracted from magnetic resonance (MR) images and a machine‐learning method to assist in differentiating breast cancer molecular subtypes.Materials and MethodsThis retrospective Health Insurance Portability and Accountability Act (HIPAA)‐compliant study received Institutional Review Board (IRB) approval. We identified 178 breast cancer patients between 2006–2011 with: 1) ERPR + (n = 95, 53.4%), ERPR–/HER2 + (n = 35, 19.6%), or triple negative (TN, n = 48, 27.0%) invasive ductal carcinoma (IDC), and 2) preoperative breast MRI at 1.5T or 3.0T. Shape, texture, and histogram‐based features were extracted from each tumor contoured on pre‐ and three postcontrast MR images using in‐house software. Clinical and pathologic features were also collected. Machine‐learning‐based (support vector machines) models were used to identify significant imaging features and to build models that predict IDC subtype. Leave‐one‐out cross‐validation (LOOCV) was used to avoid model overfitting. Statistical significance was determined using the Kruskal–Wallis test.ResultsEach support vector machine fit in the LOOCV process generated a model with varying features. Eleven out of the top 20 ranked features were significantly different between IDC subtypes with P < 0.05. When the top nine pathologic and imaging features were incorporated, the predictive model distinguished IDC subtypes with an overall accuracy on LOOCV of 83.4%. The combined pathologic and imaging model's accuracy for each subtype was 89.2% (ERPR+), 63.6% (ERPR–/HER2+), and 82.5% (TN). When only the top nine imaging features were incorporated, the predictive model distinguished IDC subtypes with an overall accuracy on LOOCV of 71.2%. The combined pathologic and imaging model's accuracy for each subtype was 69.9% (ERPR+), 62.9% (ERPR–/HER2+), and 81.0% (TN).ConclusionWe developed a machine‐learning‐based predictive model using features extracted from MRI that can distinguish IDC subtypes with significant predictive power. J. Magn. Reson. Imaging 2016;44:122–129.
Influence of rotator cuff tears on glenohumeral stability during abduction tasks
Authors: Hölscher Thomas , Weber Tim , Lazarev Igor , Englert Carsten , Dendorfer Sebastian 
Published: January 2016

ABSTRACTOne of the main goals in reconstructing rotator cuff tears is the restoration of glenohumeral joint stability, which is subsequently of utmost importance in order to prevent degenerative damage such as superior labral anterior posterior (SLAP) lesion, arthrosis, and malfunction. The goal of the current study was to facilitate musculoskeletal models in order to estimate glenohumeral instability introduced by muscle weakness due to cuff lesions. Inverse dynamics simulations were used to compute joint reaction forces for several static abduction tasks with different muscle weakness. Results were compared with the existing literature in order to ensure the model validity. Further arm positions taken from activities of daily living, requiring the rotator cuff muscles were modeled and their contribution to joint kinetics computed. Weakness of the superior rotator cuff muscles (supraspinatus; infraspinatus) leads to a deviation of the joint reaction force to the cranial dorsal rim of the glenoid. Massive rotator cuff defects showed higher potential for glenohumeral instability in contrast to single muscle ruptures. The teres minor muscle seems to substitute lost joint torque during several simulated muscle tears to maintain joint stability. Joint instability increases with cuff tear size. Weakness of the upper part of the rotator cuff leads to a joint reaction force closer to the upper glenoid rim. This indicates the comorbidity of cuff tears with SLAP lesions. The teres minor is crucial for maintaining joint stability in case of massive cuff defects and should be uprated in clinical decision‐making. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1628–1635, 2016.
Effect of solar radiation on the functional components of mulberry (Morus alba L.) leaves
Authors: Sugiyama Mari , Katsube Takuya , Koyama Akio , Itamura Hiroyuki 
Published: January 2016

AbstractBACKGROUNDThe functional components of mulberry leaves have attracted the attention of the health food industry, and increasing their concentrations is an industry goal. This study investigated the effects of solar radiation, which may influence the production of flavonol and 1‐deoxynojirimycin (DNJ) functional components in mulberry leaves, by comparing a greenhouse (poor solar radiation) and outdoor (rich solar radiation) setting.RESULTSThe level of flavonol in leaves cultivated in the greenhouse was markedly decreased when compared with those cultivated outdoors. In contrast, the DNJ content in greenhouse‐cultivated plants was increased only slightly when compared with those cultivated outdoors. Interestingly, the flavonol content was markedly increased in the upper leaves of mulberry trees that were transferred from a greenhouse to the outdoors compared with those cultivated only in the outdoors.CONCLUSIONSolar radiation conditions influence the synthesis of flavonol and DNJ, the functional components of mulberry leaves. Under high solar radiation, the flavonol level becomes very high but the DNJ level becomes slightly lower, suggesting that the impact of solar radiation is great on flavonol but small on DNJ synthesis. © 2016 Society of Chemical Industry
Predictive factors of dysphagia after lateral and superior oropharyngeal reconstruction with free flap transfer
Authors: Fujiki Masahide , Sakuraba Minoru , Miyamoto Shimpei , Hayashi Ryuichi 
Published: January 2016

Background and ObjectivesLateral and superior oropharyngeal reconstruction is technically challenging and can be complicated by postoperative dysphagia. The aim of this retrospective study was to identify the predictive factors of dysphagia after lateral and superior oropharyngeal reconstruction with free flap transfer and to establish better management for cases with these predictive factors.MethodsWe performed a retrospective chart review of 109 patients who had undergone lateral and superior oropharyngeal reconstruction with free flap transfer for oropharyngeal cancer. Preoperative, operative, and postoperative variables were examined, and possible predicative factors for dysphagia were subjected to univariate analysis and multivariate logistic regression analysis.ResultsDysphagia occurred in 16 patients (14.7%). Multivariate logistic regression analysis identified extensive tongue base resection, postoperative radiotherapy, and history of radiotherapy to the head and neck region as independent factors contributing to dysphagia after lateral and superior oropharyngeal reconstruction. Of these factors, extensive tongue base resection was the most important.ConclusionsEarly intervention to minimize the risk of dysphagia should be performed for patients identified with these predictive factors. J. Surg. Oncol. 2016;113:240–243. © 2016 Wiley Periodicals, Inc.
Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model
Authors: Orosco Ryan K. , Savariar Elamprakash N. , Weissbrod Philip A. , Diaz‐Perez Julio A. , Bouvet Michael , Tsien Roger Y. , Nguyen Quyen T. 
Published: January 2016

Background and ObjectivesMolecularly targeted fluorescent molecules may help detect tumors that are unseen by traditional white‐light surgical techniques. We sought to evaluate a fluorescent ratiometric activatable cell penetrating peptide (RACPP) for tumor detection in a transgenic model of PTC.MethodsThirteen BRAFV600E mice with PTC were studied—seven injected intravenously with RACPP, four controls with saline. Total thyroidectomy was performed with microscopic white‐light visualization. Fluorescent imaging of post‐thyroidectomy fields was performed, and tissue with increased signal was removed and evaluated for PTC. Final samples were analyzed by a pathologist blinded to conditions. Vocal cord function was evaluated postoperatively with video laryngoscopy.ResultsThe average in situ ratiometric (Cy5/Cy7) thyroid tumor‐to‐background contrast ratio was 2.27 +/− 0.91. Fluorescence‐guided clean‐up following thyroidectomy identified additional tumor in 2 of 7 RACPP animals (smallest dimension 1.2 mm), and decreased the number of animals with residual tumor from 4 to 3. All retained tumor foci on final pathology were smaller than 0.76 mm. Intact vocal abduction was present in all of the RACPP animals.ConclusionsRACPPs successfully targeted PTC in a transgenic thyroidectomy model, and allowed for residual tumor detection that reduced positive margins beyond what was possible with white‐light surgery alone. J. Surg. Oncol. 2016;113:138–143. © 2016 Wiley Periodicals, Inc.
Cytoreductive surgery and HIPEC offers similar outcomes in patients with rectal peritoneal metastases compared to colon cancer patients: a matched case control study
Authors: Simkens Geert A. , van Oudheusden Thijs R. , Braam Hidde J. , Wiezer Marinus J. , Nienhuijs Simon W. , Rutten Harm J. , van Ramshorst Bert , de Hingh Ignace H. 
Published: January 2016

Background & ObjectivesThe effect of cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with rectal peritoneal metastases (PM) is unclear. This case‐control study aims to assess the results of cytoreduction and HIPEC in patients with rectal PM compared to colon PM patients.MethodsColorectal PM patients treated with complete macroscopic cytoreduction and HIPEC were included. Two colon cancer patients were case‐matched for each rectal cancer patient, based on prognostic factors (T stage, N stage, histology type, and extent of PM). Short‐ and long‐term outcomes were compared between both groups.ResultsFrom 317 patients treated with complete macroscopic cytoreduction and HIPEC, 29 patients (9.1%) had rectal PM. Fifty‐eight colon cases were selected as control patients. Baseline characteristics were similar between groups. Major morbidity was 27.6% and 34.5% in the rectal and colon group, respectively (P = 0.516). Median disease‐free survival was 13.5 months in the rectal group and 13.6 months in the colon group (P = 0.621). Two‐ and five‐year overall survival rates were 54%/32% in rectal cancer patients, and 61%/24% in colon cancer patients (P = 0.987).ConclusionsCytoreduction and HIPEC in selected patients with rectal PM is feasible and provides similar outcomes as in colon cancer patients. Rectal PM should not be regarded a contra‐indication for cytoreduction and HIPEC in selected patients. J. Surg. Oncol. 2016;113:548–553. © 2016 Wiley Periodicals, Inc.