bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstructive challenges following blast injuries to the facial soft tissue and skeleton
Authors: McMillan Kevin , Martin Tim 
Published: April 2016

Abstract
The complex trauma seen in the battlefield provides valuable lessons for the civilian oral and maxillofacial surgeon. The nature of the current body armour places the facial skeleton at significant risk from blast injuries and these pose a challenge for the reconstructive surgeon. We present a case of a soldier who sustained multiple injuries from an improvised explosive device and presented in a physiologically compromised state. From a maxillofacial point of view there was a comminuted fracture of the mandible with a soft tissue defect of 6 cm × 5 cm in the chin area. He was treated initially with arch bars and an external fixator and the wound was packed. Over time the wound contracted and healed with no further intervention. This case demonstrates how systemic compromise may affect the initial treatment plan but an excellent outcome can still be achieved.
Efficacy of Diffusion Tensor Imaging Indices in Assessing Postoperative Neural Recovery in Cervical Spondylotic Myelopathy
Authors: Rajasekaran S. , Kanna Rishi M. , Chittode Vishnuprasath S. , Maheswaran Anupama , Aiyer Siddharth N. , Shetty Ajoy P. 
Published: April 2016

Study Design.
Prospective observational cohort study.

Objective.
The aim of this study was to analyze the efficacy of diffusion tensor imaging (DTI) anisotropy indices in predicting the postoperative recovery in cervical spondylotic myelopathy (CSM) patients and to describe postoperative changes in the DTI indices based on neurological recovery after surgery.

Summary of Background Data.
Surgical results of CSM are unpredictable and cannot be estimated based on preoperative MRI. DTI indices were found to have good sensitivity to detect changes in CSM, but their efficacy in predicting postoperative recovery and postoperative changes in DTI indices has not been studied before.

Methods.
Thirty-five patients who underwent surgical decompression for cervical spondylotic myelopathy underwent DTI evaluation preoperatively and postoperatively at 12 months. DTI indices—fractional anisotropy, apparent diffusion coefficient (ADC), relative anisotropy, volume ratio, and eigen vectors (E1, E2, and E3)—were obtained and clinical evaluations were made preoperatively and 12 months postoperatively.

Results.
Twenty-six patients were available for final follow-up at 12 months. Twenty patients showed improvement by at least 1 Nurick grade, five maintained the preoperative Nurick grade status and one patient was noted to have deterioration by 1 grade. The preoperative DTI values could not predict neurological recovery patterns postoperatively. Although conventional MRI showed adequate decompression in all patients irrespective of the clinical outcome, DTI indices showed variable results. There were significant improvements in postoperative DTI indices for ADC (P = 0.002), E1 (P < 0.001), and E2 (P = 0.012) values in patients who showed neurological recovery at 12 months. Postoperative DTI indices for coefficients ADC, E1, and E2 in neurologically static/worsened individuals remained unchanged or insignificant (P = 0.05)

Conclusion.
The DTI indices were sensitive enough to indicate postoperative neurological recovery observed following surgery. Preoperative DTI evaluation could not predict postoperative recovery for patients with cervical spondylotic myelopathy.

Level of Evidence: 4
Family Burden After Out-of-Hospital Cardiac Arrest in Children
Authors: Meert Kathleen L. , Slomine Beth S. , Christensen James R. , Telford Russell , Holubkov Richard , Dean J. Michael , Moler Frank W. 
Published: April 2016

Objectives:
To describe family burden among caregivers of children who survived out-of-hospital cardiac arrest and who were at high risk for neurologic disability and examine relationships between family burden, child functioning, and other factors during the first year post arrest.

Design:
Secondary analysis of data from the Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital trial.

Setting:
Thirty-six PICUs in the United States and Canada.

Patients:
Seventy-seven children recruited to the Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital trial who had normal prearrest neurologic functioning and were alive 1 year post arrest.

Interventions:
Family burden was assessed using the Infant Toddler Quality of Life Questionnaire for children less than 5 years old and the Child Health Questionnaire for children 5 years old or older at baseline (reflecting prearrest status), 3 months, and 12 months post arrest. Child functioning was assessed using the Vineland Adaptive Behavior Scale II, the Pediatric Overall Performance Category, and Pediatric Cerebral Performance Category scales and caregiver perception of global functioning.

Measurements and Main Results:
Fifty-six children (72.7%) were boys, 48 (62.3%) were whites, and 50 (64.9%) were less than 5 years old prior to out-of-hospital cardiac arrest. Family burden at baseline was not significantly different from reference values. Family burden was increased at 3 and 12 months post arrest compared with reference values (p < 0.001). Worse Pediatric Overall Performance Category and Pediatric Cerebral Performance Category, lower adaptive behavior, lower global functioning, and higher family burden all measured 3 months post arrest were associated with higher family burden 12 months post arrest (p < 0.05). Sociodemographics and prearrest child functioning were not associated with family burden 12 months post arrest.

Conclusions:
Families of children who survive out-of-hospital cardiac arrest and have high risk for neurologic disability often experience substantial burden during the first year post arrest. The extent of child dysfunction 3 months post arrest is associated with family burden at 12 months.
A Novel Surgical Approach to Chronic Temporal Headaches
Authors: Peled Ziv M. 
Published: April 2016

Summary:
The targets for the surgical treatment of temporal headaches are the zygomaticotemporal branch of the trigeminal nerve and the auriculotemporal nerve. The former is often accessed by means of an endoscopic brow approach or potentially by laterally extending a transpalpebral incision. An established surgical approach, the Gillies incision, was modified to access the zygomaticotemporal nerve, as it was felt to combine the advantages of the traditional techniques. Nineteen patients underwent zygomaticotemporal nerve decompression and neuroplasty or neurectomy and muscle implantation using this surgical approach. A 3.5-cm incision was made behind the anterior, temporal hairline and the zygomaticotemporal branch of the trigeminal nerve was approached directly, remaining superficial to the deep temporal fascia. Each patient was assessed preoperatively and postoperatively with regard to the frequency, duration, and severity of their symptoms to calculate a Migraine Headache Index score. All evaluations were performed at least 1 year postoperatively. The mean preoperative Migraine Headache Index score was 131.7 and the mean postoperative score was 52 (p < 0.0001). There were no surgical complications. There appeared to be no differences between those patients that had decompression and neuroplasty versus those that underwent neurectomy and implantation, as both groups experienced significant reductions in Migraine Headache Index scores following the procedure. The anterior temporal approach to the zygomaticotemporal nerve is both safe and effective. The advantages of this approach include a hidden scar, the ability to directly manipulate the nerve for transection or preservation, and access to the auriculotemporal nerve through the same incision.
A Quantitative Analysis of OnabotulinumtoxinA, AbobotulinumtoxinA, and IncobotulinumtoxinA: A Randomized, Double-Blind, Prospective Clinical Trial of Comparative Dynamic Strain Reduction
Authors: Wilson Anthony J. , Chang Brian , Taglienti Anthony J. , Chin Bianca C. , Chang Catherine S. , Folsom Nancy , Percec Ivona 
Published: April 2016

Background:
U.S. Food and Drug Administration–approved formulations of botulinum toxin include onabotulinumtoxinA (Botox; Allergan, Inc., Irvine, Calif.), abobotulinumtoxinA (Dysport; Galderma Pharma S.A., Lausanne, Switzerland), and incobotulinumtoxinA (Xeomin; Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany). This study uses digital image correlation to compare dynamic strain reduction between available neurotoxins.

Methods:
Seventy-three treatment-naive female patients aged were randomized to injection with onabotulinumtoxinA (20 units), abobotulinumtoxinA (60 units), or incobotulinumtoxinA (20 units) in the glabella. Imaging was conducted at 4, 14, and 90 days after injection. Change in average dynamic strain of the glabella was compared using ANOVA.

Results:
At day 4, there was a 42.1 percent strain reduction in the onabotulinumtoxinA group, a 39.4 percent strain reduction in the abobotulinumtoxinA group, and a 19.8 percent strain reduction in the incobotulinumtoxinA group (onabotulinumtoxinA versus abobotulinumtoxinA, p = 0.77; onabotulinumtoxinA versus incobotulinumtoxinA, p = 0.02; and abobotulinumtoxinA versus incobotulinumtoxinA, p = 0.04). At day 14, there was a 66.1 percent strain reduction in the onabotulinumtoxinA group, a 51.4 percent strain reduction in the abobotulinumtoxinA group, and a 42.8 percent strain reduction in the incobotulinumtoxinA group (onabotulinumtoxinA versus abobotulinumtoxinA, p = 0.14; onabotulinumtoxinA versus incobotulinumtoxinA, p = 0.02; and abobotulinumtoxinA versus incobotulinumtoxinA, p = 0.36). At day 90, there was a 43.5 percent strain reduction in the onabotulinumtoxinA group, a 38.4 percent strain reduction in the abobotulinumtoxinA group, and a 25.3 percent strain reduction in the incobotulinumtoxinA group (onabotulinumtoxinA versus abobotulinumtoxinA, p = 0.66; onabotulinumtoxinA versus incobotulinumtoxinA, p = 0.12; and abobotulinumtoxinA versus incobotulinumtoxinA, p = 0.24).

Conclusions:
Using digital image correlation, the tested neuromodulators do not have equivalent strain reduction in the glabella at the doses used. These results confirm assertions of noninterchangeability.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, II.
Interventions to Decrease Postoperative Edema and Ecchymosis after Rhinoplasty: A Systematic Review of the Literature
Authors: Ong Adrian A. , Farhood Zachary , Kyle Andrew R. , Patel Krishna G. 
Published: April 2016

Background:
Today, minimally invasive procedures are becoming more popular because of the fast recovery. Rhinoplasty is a common facial plastic surgery procedure that can be associated with significant postoperative morbidities, especially periorbital edema and ecchymosis. The aim of this review is to summarize the results of published literature that studied interventions that decrease postoperative edema and ecchymosis after rhinoplasty, and provide evidence-based strategies for surgeons to incorporate into practice.

Methods:
A systematic review of the PubMed, Scopus, and EMBASE databases was performed to investigate interventions studied to decrease postoperative edema and ecchymosis after rhinoplasty. After inclusion and exclusion criteria were applied, articles were grouped into one of the following categories: corticosteroids, other medications and herbal supplements, interventions to decrease intraoperative bleeding, other postoperative interventions, and surgical techniques.

Results:
A total of 50 articles were included for review. Fourteen articles studied corticosteroids exclusively, whereas another 10 articles reviewed other medications and herbal supplements. Nine articles evaluated methods to decrease intraoperative bleeding during rhinoplasty, and four articles studied postoperative interventions to decrease edema and ecchymosis. Thirteen articles studied various surgical techniques to decrease postoperative morbidities.

Conclusions:
There was a consensus within the literature that steroids, intraoperative hypotension, intraoperative cooling, and head elevation postoperatively decrease postoperative edema and ecchymosis, whereas nasal packing and periosteal elevation before osteotomy increased these postoperative morbidities. Studies of herbal supplements may be incorporated into practice with minimal risk to the patient. More studies must be performed before recommending an external or internal approach to lateral osteotomy.
Paradoxical signaling regulates structural plasticity in dendritic spines
Authors: Rangamani Padmini , Levy Michael G. , Khan Shahid M. , Oster George 
Published: April 2016

AbstractTransient spine enlargement (3-5 min timescale) is an important event associated with the structural plasticity of dendritic spines. Many of the molecular mechanisms associated with transient spine en­largement have been identified experimentally. Here, we use a systems biology approach to construct a mathematical model of biochemical signaling and actin-mediated transient spine expansion in response to calcium-influx due to NMDA receptor activation. We have identified that a key feature of this signaling network is the paradoxical signaling loop. Paradoxical components act bifunctionally in signaling net­works and their role is to control both the activation and inhibition of a desired response function (protein activity or spine volume). Using ordinary differential equation (ODE)-based modeling, we show that the dynamics of different regulators of transient spine expansion including CaMKII, RhoA, and Cdc42 and the spine volume can be described using paradoxical signaling loops. Our model is able to capture the experimentally observed dynamics of transient spine volume. Furthermore, we show that actin remod­eling events provide a robustness to spine volume dynamics. We also generate experimentally testable predictions about the role of different components and parameters of the network on spine dynamics.
Predicting Drug Synergy and Antagonism from Genetic Interaction Neighborhoods
Authors: Young Jonathan H. , Marcotte Edward M. 
Published: April 2016

AbstractAlthough drug combinations have proven efficacious in a variety of diseases, the design of such regimens often involves extensive experimental screening due to the myriad choice of drugs and doses. To address these challenges, we utilize the budding yeast Saccharomyces cerevisiae as a model organism to evaluate whether drug synergy or antagonism is mediated through genetic interactions between their target genes. Specifically, we hypothesize that if the inhibition targets of one chemical compound are in close proximity to those of a second compound in a genetic interaction network, then the compound pair will exhibit synergy or antagonism. Graph metrics are employed to make precise the notion of proximity in a network. Knowledge of genetic interactions and small-molecule targets are compiled through literature sources and curated databases, with predictions validated according to experimentally determined gold standards. Finally, we test whether genetic interactions propagate through networks according to a “guilt-by-association” framework. Our results suggest that close proximity between the target genes of one drug and those of another drug does not strongly predict synergy or antagonism. In addition, we find that the extent to which the growth of a double gene mutant deviates from expectation is moderately anti-correlated with their distance in a genetic interaction network.
Stay tuned: active amplification tunes tree-cricket ears to track temperature-dependent song frequency
Authors: Mhatre Natasha , Pollack Gerald , Mason Andrew 
Published: April 2016

AbstractTree cricket males produce tonal songs, used for mate-attraction and male-male interactions. Active mechanics tunes hearing to conspecific song frequency. However, tree cricket song frequency increases with temperature, presenting a problem for tuned listeners. We show that the actively amplified frequency increases with temperature, thus shifting mechanical and neuronal auditory tuning to maintain a match with conspecific song frequency. Active auditory processes are known from several taxa, but their adaptive function has rarely been demonstrated. We show that tree crickets harness active processes to ensure that auditory tuning remains matched to conspecific song frequency, despite changing environmental conditions and signal characteristics. Adaptive tuning allows tree crickets to selectively detect potential mates or rivals over large distances and is likely to bestow a strong selective advantage by reducing mate-finding effort and facilitating intermale interactions.
MicroRNA858 Is a Potential Regulator of Phenylpropanoid Pathway and Plant Development
Authors: Sharma Deepika , Tiwari Manish , Pandey Ashutosh , Bhatia Chitra , Sharma Ashish , Trivedi Prabodh Kumar 
Published: April 2016

Abstract
MicroRNAs (miRNAs) are endogenous, noncoding small RNAs that function as critical regulators of gene expression. In plants, miRNAs have shown their potential as regulators of growth, development, signal transduction, and stress tolerance. Although the miRNA-mediated regulation of several processes is known, the involvement of miRNAs in regulating secondary plant product biosynthesis is poorly understood. In this study, we functionally characterized Arabidopsis (Arabidopsis thaliana) miR858a, which putatively targets R2R3-MYB transcription factors involved in flavonoid biosynthesis. Overexpression of miR858a in Arabidopsis led to the down-regulation of several MYB transcription factors regulating flavonoid biosynthesis. In contrast to the robust growth and early flowering of miR858OX plants, reduction of plant growth and delayed flowering were observed in Arabidopsis transgenic lines expressing an artificial miRNA target mimic (MIM858). Genome-wide expression analysis using transgenic lines suggested that miR858a targets a number of regulatory factors that modulate the expression of downstream genes involved in plant development and hormonal and stress responses. Furthermore, higher expression of MYBs in MIM858 lines leads to redirection of the metabolic flux towards the synthesis of flavonoids at the cost of lignin synthesis. Altogether, our study has established the potential role of light-regulated miR858a in flavonoid biosynthesis and plant growth and development.
Velocity‐saturation relation in partially saturated rocks: Modelling the effect of injection rate changes
Authors: Liu Jiawei , Müller Tobias M. , Qi Qiaomu , Lebedev Maxim , Sun Weitao 
Published: April 2016

ABSTRACTThe relationship between P‐wave velocity and fluid saturation in a porous medium is of importance for reservoir rock characterization. Forced imbibition experiments in the laboratory reveal rather complicated velocity–saturation relations, including rollover‐like patterns induced by injection rate changes. Poroelasticity theory‐based patchy saturation models using a constant fluid patch size are not able to describe these velocity–saturation relations. Therefore, we incorporate a saturation‐dependent patch size function into two models for patchy saturation. This recipe allows us to model observed velocity–saturation relations obtained for different and variable injection rates. The results reveal an increase in patch size with fluid saturation and show a reduction in the patch size for decreasing injection rate. This indicates that there can exist a distinct relation between patch size and injection rate. We assess the relative importance of capillarity on velocity–saturation relations and find that capillarity stiffening impairs the impact of patch size changes. Capillarity stiffening appears to be a plausible explanation when a decrease in the injection rate is expected to boost the importance of capillarity.
Wind exposure and light exposure, more than elevation‐related temperature, limit tree line seedling abundance on three continents
Authors: McIntire Eliot J. B. , Piper Frida I. , Fajardo Alex 
Published: April 2016

Summary

The transition from seedlings into trees at alpine tree lines is a temperature‐limited process that ultimately sets the tree line elevation at a global scale. As such, tree lines may be key bioassays of global warming effects on species distributions. For global warming to promote upward tree line migration, as predicted, seedlings must be available. We examined, for the first time at a global scale, elevational patterns and drivers of seedling availability at tree lines.

Working at 10 sites across five mountain regions (dry Andes, humid Andes, Patagonian Andes, Swiss Alps and US Rocky Mountains) with different tree line forms (abrupt and diffuse) and dominated by different tree species (broadleaves and conifers), we answered the following question: How is seedling abundance affected by elevation (as a coarse grain surrogate of temperature), light exposure (openness immediately above plots) or wind exposure (an index for openness in the horizontal direction), or combinations thereof and what is the relative importance of each factor?

We tested five biological hypotheses to determine the relative strength of these tree line drivers on variable‐size sampling plots of seedling abundance (S) (n = 1056). Specifically, we tested likely combinations of temperature limitation (T), light as a resource (light, L) and as a radiation stress (via high light at low temperature, R), wind exposure as a tree line stressor (W) and tree line form (a coarse scale test: abrupt vs. diffuse, D).

We found strong, moderate and weak negative effects of our estimates of wind exposure, radiation stress and elevation‐related temperature on seedling abundance, respectively. We also found a positive effect, at tree line, for site‐level tree line diffuseness. Two distinct facilitation mechanisms likely improved seedling abundance at tree line elevation: wind blockage by neighbourhood trees (the sheltering effect) and partial shading by overhead trees.

Synthesis. Seedling abundance at alpine tree lines is limited by multiple simultaneous factors with the temperature decrease with elevation playing a relatively minor role. We therefore note that if the temperature threshold limiting the conversion from seedlings to adult trees is relaxed because of global warming, upward tree line migration will depend on the availability of shelter sites for seedlings.
Party on wheels: mobile party spaces in the Norwegian high school graduation celebration
Authors: Fjær Eivind Grip , Pedersen Willy , Sandberg Sveinung 
Published: April 2016

AbstractResearch on partying and nightlife often emphasizes commercial control while overlooking participants’ creativity and agency. Due to their age, appearance and transgressive partying, participants in the Norwegian high school graduation celebration have limited access to bars and pubs in the ordinary night‐time economy. To create alternative party spaces under their own control they utilize the spatial opportunities offered by automobility. Groups of students get together many years in advance and buy old buses which they refurbish to become rolling nightclubs that enable them to ‘transcend space’ through partying while on the move. These mobile party spaces provide a material and symbolic centre of communion and a tight space for physical assembly that enhances the production of intense positive emotions. In a cat‐and‐mouse game with the police, the buses provide a sense of nomadic autonomy, and enable participants to drink heavily for days on end. The study examines how youth may creatively zone their own party spaces within the context of automobility and how these mobile spaces again shape the partying that goes on within them. While this party practice opens up for autonomy, creativity and social transgressions reminiscent of liminal phases or carnivals, at a deeper level participants clearly reproduce class‐based differences and exaggerate conventional practices and symbols.