bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simple and robust trajectory‐based stereotactic radiosurgery treatment
Authors: Wilson Byron , Otto Karl , Gete Ermias 
Published: January 2017

IntroductionWe present a Trajectory‐based Volumetric Modulated Arc Therapy (TVMAT) technique for Stereotactic Radiosurgery (SRS) that takes advantage of a modern linacs ability to modulate dose rate and move the couch dynamically. In addition, we investigate the quality of the developed TVMAT method and the dosimetric accuracy of the technique.MethodsThe main feature of the TVMAT technique is a standard beam trajectory formed by dynamic motion of the treatment couch and the linac gantry. The couch rotates slowly through 180 degrees while the gantry delivers radiation through continuous sweeps of the gantry. The number of partial arcs that constitute the trajectory can be varied between two and eight and as the number of partial arcs increases, the trajectory more finely samples 4π geometry. Along these trajectories, the multi‐leaf collimator (MLC) and dose rate are optimized through an inverse planning framework. The TVMAT method was tested on ten cranial SRS patients who were previously treated with the Dynamic Conformal Arc (DCA) technique. The plans were compared with the DCA and a four‐ arc VMAT technique with regards to dose to the OAR, dose falloff, V12Gy, and V4Gy. Validation measurements were performed using ion‐chamber and Gafchromic film. In addition, the trajectory‐log files were analyzed and compared with the treatment plan beam data.ResultsThe TVMAT treatment plans were successfully delivered with a treatment time between 3–8 min which mostly depended on total cumulated dose. Ion chamber measurements had an average measured error of 1.1 ± 0.6% and a maximum value of 2.2% of the delivered dose. The 2%, 2 mm gamma pass rates for the film measurements were 96% or greater. In a preliminary comparison of ten patients who underwent SRS treatments with the DCA technique, the TVMAT and VMAT techniques were able to produce plans with comparable dose falloff and OAR doses, while achieving better dose conformality, V4Gy and V12Gy when compared to the original DCA plans. The improvement of the TVMAT plans were as follows (mean % improvement ± standard err): Conformity (10 ± 2%), V4 (20 ± 20%), V12 (27 ± 10%), volume weighted mean dose to organs at risk (13 ± 13%), homogeneity index (2 ± 2%) and falloff (4 ± 2%).ConclusionWe have developed and validated a trajectory‐based dose delivery method which has dose distribution improvements while having a treatment time of 3–8 min. In addition, it has the potential for a simpler planning experience while maintaining an accurate delivery on the Varian Truebeam Linac.
Mapping the road from childhood adversity to personality disorder: The role of unresolved states of mind
Authors: Cirasola Antonella , Hillman Saul , Fonagy Peter , Chiesa Marco 
Published: January 2017

AbstractChildhood adversity has been found to be an important aetiological factor in the development of personality disorder (PD) in several studies. However, the role of disorganized attachment with unresolved mental states for traumatic experiences requires further investigation. This study explores the relationship between childhood adversities, unresolved states of mind, PD diagnosis and psychiatric distress. Two hundred forty‐five adult participants, 124 from a clinical PD group and 121 non‐psychiatric controls were assessed using the Structured Clinical Interview for DSM‐IV, the Cassel Baseline Questionnaire, the Symptom Checklist‐90‐R and the Adult Attachment Interview, in order to ascertain presence of PD, childhood adversity, level of psychiatric distress and unresolved states of mind. Within the overall unresolved (U‐overall) attachment category, a distinction was made between unresolved for abuse (U‐abuse) and unresolved for loss (U‐loss). The results indicated that childhood adversity was significantly associated with unresolved states of mind, as well as with overall PD diagnosis, paranoid PD, borderline PD, avoidant PD and psychiatric distress. Mediation analyses confirmed that U‐overall and U‐loss were significant mediators between childhood adversity and PD diagnoses, but surprisingly, U‐abuse was not a significant mediator. The strength, limitations and clinical implications of the findings are discussed. Copyright © 2017 John Wiley & Sons, Ltd.
Do Individual Employees' Learning Goal Orientation and Civic Virtue Matter? A Micro‐Foundations Perspective on Firm Absorptive Capacity
Authors: Yao Fiona K. , Chang Song 
Published: January 2017

Research summary: In this study, we build on the micro‐foundations perspective and investigate how individual characteristics contribute to the development of firm absorptive capacity. In particular, we assess how individual learning goal orientation affects firm potential and realized absorptive capacity. Furthermore, we study how individuals' civic virtue acts as a micro‐level social integration mechanism that moderates the effect from firm realized absorptive capacity to potential absorptive capacity. Using the multilevel structural equation modeling technique and data from 871 core‐knowledge employees nested in 139 high‐technology firms, we find support to our major hypotheses. Together, this study finds support for the micro‐foundations' perspective and generates novel insights on how individual‐level factors could be linked with firm‐level heterogeneity in absorptive capacity.Managerial summary: We study how employees' characteristics contribute to a firm's absorptive capacity, that is, the ability of a firm to identify, assimilate, and exploit knowledge from the environment. Because firms have increasingly tapped into external resources to foster innovation over the past two decades, absorptive capacity is crucial to firm learning and success. Using data from 871 core‐knowledge employees in 139 high‐technology firms, we find that individual employees' learning goal orientation, the tendency to seek improvements in employees' competence and to understand or master new things advances the development of a firm's potential and realized absorptive capacity. More important, individual employees' civic virtue, the discretionary involvement in company issues, serves as a social integration mechanism that reduces the gap between firm potential and realized absorptive capacity. Copyright © 2017 John Wiley & Sons, Ltd.
Ripple Effects of CEO Awards: Investigating the Acquisition Activities of Superstar CEOs' Competitors
Authors: Shi Wei , Zhang Yan , Hoskisson Robert E. 
Published: January 2017

Research summary: This study proposes that CEOs may undertake intensive acquisition activities to increase their social recognition and status after witnessing their competitors' winning CEO awards. Using a sample of U.S. S&P 1,500 firm CEOs, we find that CEOs engage in more intensive acquisition activities in the period after their competitors won CEO awards (i.e., postaward period), compared to the preaward period. Moreover, this effect is stronger when focal CEOs themselves had a high likelihood of winning CEO awards. Our findings also show that acquisitions by focal CEO firms in the postaward period realize lower announcement returns compared to acquisitions by the same CEOs in the preaward period.Managerial summary: Each year a few CEOs receive CEO awards from business media and CEOs who receive such awards become instant celebrities, that is, superstar CEOs. This study explores how superstar CEOs' competitors react to not winning CEO awards. We find that superstar CEOs' competitors undertake more intensive acquisition activities in the postaward period compared to the preaward period. This is particularly true for competitors who were close, yet did not win CEO awards. In addition, acquisitions by superstar CEOs' competitors are associated with lower announcement returns in the postaward compared to the preaward period. These findings collectively indicate that acquisitions may be used as a channel for superstar CEOs' competitors to elevate their own social status, but at a cost to shareholders. Copyright © 2017 John Wiley & Sons, Ltd.
Pulmonary Metastasis After Resection of Cholangiocarcinoma: Incidence, Resectability, and Survival
Authors: Yamada Mihoko , Ebata Tomoki , Yokoyama Yukihiro , Igami Tsuyoshi , Sugawara Gen , Mizuno Takashi , Yamaguchi Junpei , Nagino Masato 
Published: January 2017

AbstractBackgroundThere are few reports on pulmonary metastasis from cholangiocarcinoma; therefore, its incidence, resectability, and survival are unclear.MethodsPatients who underwent surgical resection for cholangiocarcinoma, including intrahepatic, perihilar, and distal cholangiocarcinoma were retrospectively reviewed, and this study focused on patients with pulmonary metastasis.ResultsBetween January 2003 and December 2014, 681 patients underwent surgical resection for cholangiocarcinoma. Of these, 407 patients experienced disease recurrence, including 46 (11.3%) who developed pulmonary metastasis. Of these 46 patients, 9 underwent resection for pulmonary metastasis; no resection was performed in the remaining 37 patients. R0 resection was achieved in all patients, and no complications related to pulmonary metastasectomy were observed. The median time to recurrence was significantly longer in the 9 patients who underwent surgery than in the 37 patients without surgery (2.5 vs 1.0 years, p < 0.010). Survival after surgery for primary cancer and survival after recurrence were significantly better in the former group than in the latter group (after primary cancer: 66.7 vs 0% at 5 years, p < 0.001; after recurrence: 40.0 vs 8.7% at 3 years, p = 0.003). Multivariate analysis identified the time to recurrence and resection for pulmonary metastasis as independent prognostic factors for survival after recurrence.ConclusionResection for pulmonary metastasis originating from cholangiocarcinoma can be safely performed and confers survival benefits for select patients, especially those with a longer time to recurrence after initial surgery.
Construction of a novel lipolytic fusion biocatalyst GDEst-lip for industrial application
Authors: Gudiukaite Renata , Sadauskas Mikas , Gegeckas Audrius , Malunavicius Vilius , Citavicius Donaldas 
Published: January 2017

Abstract
The gene encoding esterase (GDEst-95) from Geobacillus sp. 95 was cloned and sequenced. The resulting open reading frame of 1497 nucleotides encoded a protein with calculated molecular weight of 54.7 kDa, which was classified as a carboxylesterase with an identity of 93–97% to carboxylesterases from Geobacillus bacteria. This esterase can be grouped into family VII of bacterial lipolytic enzymes, was active at broad pH (7–12) and temperature (5–85 °C) range and displayed maximum activity toward short acyl chain p-nitrophenyl (p-NP) esters. Together with GD-95 lipase from Geobacillus sp. strain 95, GDEst-95 esterase was used for construction of fused chimeric biocatalyst GDEst-lip. GDEst-lip esterase/lipase possessed high lipolytic activity (600 U/mg), a broad pH range of 6–12, thermoactivity (5–85 °C), thermostability and resistance to various organic solvents or detergents. For these features GDEst-lip biocatalyst has high potential for applications in various industrial areas. In this work the effect of additional homodomains on monomeric GDEst-95 esterase and GD-95 lipase activity, thermostability, substrate specificity and catalytic properties was also investigated. Altogether, this article shows that domain fusing strategies can modulate the activity and physicochemical characteristics of target enzymes for industrial applications.
Prevalence and Characteristics of Patients with Suspected Inherited Renal Cell Cancer: Application of the ACMG/NSGC Genetic Referral Guidelines to Patient Cohorts
Authors: Truong Hong , Hegarty Sarah E. , Gomella Leonard G. , Kelly William K. , Trabulsi Edouard J. , Lallas Costas D. , Giri Veda N. 
Published: January 2017

AbstractPatients with suspected hereditary renal cell cancer (RCC) are under‐referred for genetic evaluation. Characterizing the prevalence and characteristics of suspected inherited RCC is a crucial step toward advancing personalized, genetically‐based cancer risk management for patients and their families. To evaluate the prevalence and characteristics of suspected inherited RCC syndromes based on consensus criteria, we performed a cross‐sectional analysis of patients with a diagnosis of RCC in SEER (2001–2011, n = 105,754) and in our institutional cancer registry (2004–2013, n = 998). Consensus criteria for referral of patients with RCC for genetic evaluation from the American College of Medical Genetics and Genomics and National Society of Genetic Counselors (ACMG/NSGC) were applied to the two cohorts. The associations between meeting referral criteria with demographic characteristics were assessed with chi‐square tests. Overall, 24.0 % of the SEER cohort and 33.7 % of our institutional cohort met ACMG/NSGC referral criteria for genetic counseling. While white patients more commonly met early onset clear cell RCC criteria, black patients met papillary RCC criteria at twice the rate of whites in both cohorts (p < 0.0001). As many as 1 in 5 individuals with RCC meet referral criteria for genetic evaluation based on newly emerging guidelines, with differences in pathology noted by race. Prospective genetic testing studies utilizing emerging referral guidelines should help to refine the genetic spectrum of inherited kidney cancer. This study supports efforts to increase awareness of referral of patients with RCC for genetic counseling particularly among urologic providers.
The association between childhood trauma, parental bonding and depressive symptoms and interpersonal functioning in depression and bipolar disorder
Authors: Marshall M. , Shannon C. , Meenagh C. , Mc Corry N. , Mulholland C. 
Published: January 2017

ObjectivesThis study explores rates of a history of childhood trauma in adult patients with bipolar disorder and depression and the impact of such trauma and parental bonding patterns on depressive mood and interpersonal functioning at the time of assessment.MethodsA cross-sectional design was used and a sample of 49 participants was recruited from a mental health outpatient service in Northern Ireland. Data were subject to correlations, one-way analysis of variance and hierarchal regression analyses. A cut-off point of r=±0.25 was used to select variables for inclusion in the hierarchal regression analyses.ResultsHigh rates of childhood trauma were present in both samples: 74% in bipolar disorder and 82% in depression. Childhood trauma and poor parental bonding (with mother) were significant predictors of higher rates of current inter-episode depressive mood and interpersonal difficulties.ConclusionsThis finding adds to the evidence that routine assessment of early childhood experience is likely to prove helpful in clinical care.
Asymptotic theory for torsional convection in rotating fluid spheres
Authors: Zhang Keke , Lam Kameng , Kong Dali 
Published: January 2017

This paper is concerned with the classical, well-studied problem of convective instabilities in rapidly rotating, self-gravitating, internally heated Boussinesq fluid spheres. Sanchez et al. (J. Fluid Mech., vol. 791, 2016, R1) recently found, unexpectedly via careful numerical simulation, that non-magnetic convection in the form of axially symmetric, equatorially antisymmetric torsional oscillation is physically preferred in a special range of small Prandtl number for rapidly rotating fluid spheres with the stress-free boundary condition. We derive an asymptotic solution describing convection-driven torsional oscillation – whose flow velocity and pressure are fully analytical and in closed form – that confirms the result of the numerical analysis and is in quantitative agreement with the numerical solution. We also demonstrate, through the derivation of a different asymptotic solution, that convection-driven torsional oscillation cannot occur in rapidly rotating fluid spheres with the no-slip boundary condition.
The effectiveness of high-involvement work practices in manufacturing firms: Does context matter?
Authors: Vazquez-Bustelo Daniel , Avella Lucía 
Published: January 2017

AbstractThis paper adopts an integrative and complementary approach to the universalistic and contingency frameworks for analyzing the effectiveness of high-involvement work practices (HIWPs) in Spanish manufacturers. It focuses on some practices that firms adopt at operational level (decentralization, teamwork, job enlargement, information and knowledge sharing and performance-based compensation) to enhance operational performance (cost, quality, flexibility and delivery) and financial performance (return on asset), dealing with the possible moderating effect of three contextual variables: firm age, firm size and trade union power. Using moderated hierarchical regressions and data from 265 Spanish manufacturers, our results show that three of the five HIWPs considered in our study have direct effects on business performance. We also find that three contextual variables have moderating effects on the relation between HIWPs and business performance. Our paper contributes to the debate over the respective merits of the universalistic and contingency frameworks; it offers a broader view about the type of contemporary human resources practices that are successful in the Spanish industrial sector, and in a European manufacturing context, and may guide managers when assigning their firms’ limited resources to the most relevant human resources practices in each particular setting, considering internal characteristics, such as firm age, firm size and trade union power.
Characterization of the complete mitochondrial genome of Setaria digitata (Nematoda: Setariidae) from China
Authors: Liu G.-H. , Li J.-Y. , Zhu X.-Q. 
Published: January 2017

AbstractSetaria digitata is a filarial parasite that causes fatal cerebrospinal nematodiasis in goats, horses and sheep, resulting in substantial economic losses to livestock farmers. In the present study, the complete mitochondrial (mt) genome of S. digitata from China was determined, characterized and compared with that of S. digitata from Sri Lanka. The identity of the mt genomes was 98.3% between S. digitata from China and Sri Lanka, and the complete mt genome sequence of S. digitata from China was slightly shorter (25 bp) than that from Sri Lanka. For the 12 protein genes, this comparison revealed sequence differences at both the nucleotide (1.4%) and amino acid (2.2%) levels. The present study determined the complete mt genome sequence of S. digitata from China, providing novel genetic markers for the study of the population genetics and molecular epidemiology of S. digitata in animals.
Roman Roadworks near Vindolanda and theCohors I Tungrorum
Authors: Birley Anthony R. 
Published: January 2017

ABSTRACTOn the Stanegate near Vindolanda two milestones are stillin situ. The complete eastern one lacks an inscription. Only the base of the western one survives, cut down and splitc. 1815; but eighteenth-century antiquaries read an inscription on it, now recognised as secondary, and a little of a primary text, probably naming Hadrian and perhaps a Tungrian unit. Writing-tablets and inscriptions showcohors I Tungrorumat Vindolanda in the late first and early second century, so it may have set up the milestone. Evidence from elsewhere names army units as road-builders on milestones. The distance between the Stanegate milestones is greater than the ‘standard’ length, hence perhaps the so-calledpes Drusianuswas used. The final section discusses the secondary inscription.
Seeing Marcellus inAeneid6
Authors: Freudenburg Kirk 
Published: January 2017

ABSTRACTThis paper will examine the claims of theexcudent alii(‘others will hammer out’) priamel ofAeneid6.847–53 within the immediate context of the parade's end, where Marcellus, parading thespolia opima,is used to exemplify the claims made about fine and speculative arts belonging to the Greeks, and war and the arts of empire to the Romans. It will be shown that certain, highly specific memories of the elder Marcellus are cued by the priamel that run directly counter to Anchises’ claims. The paper will look at how these claims are spoken in character, and driven by specific narrative motives, and it will relate the mismatch of exemplified to exemplifier to certain larger patterns within theAeneidof things being left unsaid only to stand out all the more by being left unsaid. The paper concludes with a speculative essay on the necessary reductions and revisions that go into the making, and reading, of culturally instrumentalized monuments.
Bottoms up! How top-down pitfalls ensnare speech perception researchers, too
Authors: Cutler Anne , Norris Dennis 
Published: January 2017

AbstractNot only can the pitfalls that Firestone & Scholl (F&S) identify be generalised across multiple studies within the field of visual perception, but also they have general application outside the field wherever perceptual and cognitive processing are compared. We call attention to the widespread susceptibility of research on the perception of speech to versions of the same pitfalls.
How cognition affects perception: Brain activity modelling to unravel top-down dynamics
Authors: Desseilles Martin , Phillips Christophe 
Published: January 2017

AbstractIn this commentary on Firestone & Scholl's (F&S's) article, we argue that researchers should use brain-activity modelling to investigate top-down mechanisms. Using functional brain imaging and a specific cognitive paradigm, modelling the BOLD signal provided new insight into the dynamic causalities involved in the influence of cognitions on perceptions.
Young children's knowledge about the links between writing and language
Authors: TREIMAN REBECCA , BOLAND KELLY 
Published: January 2017

ABSTRACTThe present study tested the hypothesis (Byrne, 1996) that young children who do not yet understand that the elements of alphabetic writing represent phonemes link writing to language at the level of morphemes. We asked US preschoolers to write words that varied in the number of morphemes and the number of syllables that they contained. We identified a group of 50 children who used letters that represented phonemes in the intended words no more often than expected by chance (mean age = 4 years, 9 months). These prephonological spellers did not produce longer spellings for two-morpheme words such as teacup than for one-morpheme words such as napkin, although the length of their spellings was affected by the number of letters that they used to spell the previously presented word and by the order of the word in the experiment. The results suggest that the length of prephonological spellers’ productions is not influenced by the linguistic length of a message in phonemes, syllables, or morphemes, and they do not support the idea that these children show a special sensitivity to morphemes.
Security expertise and international hierarchy: the case of ‘The Asia-Pacific Epistemic Community’
Authors: Jerdén Björn 
Published: January 2017

AbstractMany states partially relinquish sovereignty in return for physical protection from a more powerful state. Mainstream theory on international hierarchies holds that such decisions are based on rational assessments of the relative qualities of the political order being offered. Such assessments, however, are bound to be contingent, and as such a reflection of the power to shape understandings of reality. Through a study of the remarkably persistent US-led security hierarchy in East Asia, this article puts forward the concept of the ‘epistemic community’ as a general explanation of how such understandings are shaped and, hence, why states accept subordinate positions in international hierarchies. The article conceptualises a transnational and multidisciplinary network of experts on international security – ‘The Asia-Pacific Epistemic Community’ – and demonstrates how it operates to convince East Asian policymakers that the current US-led social order is the best choice for maintaining regional ‘stability’.