bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short- and Longer-Term Association Between Body Mass Index and Health Status in Cardiac Rehabilitation Patients
Authors: Pieters Kimberley , Spronk Angela , Sunamura Madoka , Dulfer Karolijn , ter Hoeve Nienke , Utens Elisabeth M. W. J. , van Domburg Ron T. 
Published: September 2017

Purpose:
The association between body mass index (BMI) and subjective health status before and after cardiac rehabilitation (CR) and 1 year later was compared in patients undergoing primary percutaneous coronary intervention (pPCI) who did (CR group) and did not receive CR (no-CR group). The aim was to investigate the association between BMI and subjective health status based on the Short Form-12 questionnaire.

Methods:
Between 2009 and 2011, 242 patients with pPCI with an acute myocardial infarction completed a CR program and were compared with 115 patients in the no-CR group. All patients completed the Short Form-12 questionnaire at baseline, at 12 weeks, and at 1-year followup. The CR program consisted of a 2 sessions per week for 1.5 hours each for 12 weeks. Patients were categorized into 3 groups based on BMI: normal weight, overweight, and obese.

Results:
Compared with patients in the no-CR group, CR group patients in the overweight group significantly improved their subjective health status after CR and these improvements were sustained at 1-year followup. CR patients in the normal weight and obese groups did not significantly improve subjective health status. The overweight patients had the highest improvement in subjective health status (OR = 3.4 post-CR and 5.1 at 1 year of followup).

Conclusions:
After CR, overweight patients showed the best improvement in subjective health status. CR did not significantly improve subjective health status in normal-weight and obese patients.
Treatment of Metastatic Eyelid Carcinoma
Authors: Bonavolontà Paola , Dell’Aversana Orabona Giovanni , Abbate Vincenzo , Iaconetta Giorgio , Bonavolontà Giulio , Califano Luigi 
Published: September 2017

Purpose:
The aim of this study was to report management and outcomes in patients affected by eyelids carcinomas involving regional lymph nodes.

Methods:
We have retrospectively analyzed the data of patients affected by eyelids carcinoma with nodal involvement. The clinical records of 10 patients with malignant eyelid carcinoma and regional nodal metastasis treated between September 2011 and March 2015 have been analyzed.

Results:
The study included 5 women and 5 men (median age 54,5 years; range 37–80 years). The most common tumor was the squamous cell carcinoma (4 cases) followed by sebaceous carcinoma (2 cases): 1 case of epidermoid carcinoma, 1 case of malignant melanoma, 1 case of Merkel carcinoma, and 1 case of basal cell carcinoma. All patients were treated by surgical resection; in 2 cases, orbital exenteration was required. The treatment of regional nodal metastasis consisted of parotidectomy and radical neck dissection followed by radiation therapy. None of the patients developed local recurrence. Three patients died: one, affected by Merkel cell carcinoma, died after 2 months because of metastatic dissemination to the lung; another one, affected by epidermoid carcinoma involving the orbit, died because of liver metastasis; the third one, affected by malignant melanoma, died because of other causes. The follow-up time ranged from 9 to 36 months (median 19.3 months).

Conclusions:
Patients affected by advanced malignant eyelid carcinoma need to be strictly controlled because metastasis can develop at least 5 years after surgical treatment. Therapy may include a combination of local surgery, neck dissection, and radiation.
Automated Evaluation of Choroidal Thickness and Minimum Rim Width Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy
Authors: Pérez-Sarriegui Ane , Muñoz-Negrete Francisco J. , Noval Susana , De Juan Victoria , Rebolleda Gema 
Published: September 2017

Background:
The aim of this study was to evaluate and compare peripapillary choroidal thickness (pCT) and macular choroidal thickness (CT), Bruch membrane opening-minimum rim width (BMO-MRW), retinal nerve fiber layer (RNFL) thickness, and optic disc area among nonarteritic anterior ischemic optic neuropathy (NAION) eyes, the contralateral unaffected eyes, and healthy control eyes.

Methods:
Twenty-six patients diagnosed with NAION (29 affected and 21 unaffected eyes) and 29 healthy matched control individuals (29 eyes) were analyzed by swept-source optical coherence tomography. All participants underwent scanning by Spectralis optical coherence tomography to analyze BMO-MRW, RNFL thickness, and optic disc area.

Results:
Mean pCT in the NAION eyes, unaffected fellow eyes, and the control group was 130.5 ± 72.1 μm, 149.6 ± 75.7 μm, and 103.7 ± 36.7 μm, respectively (analysis of variance [ANOVA], P = 0.04). Mean macular CT in the NAION eyes, unaffected fellow eyes, and the control group was 226.1 ± 79.8 μm, 244.6 ± 81.4 μm, and 189.9 ± 56.4 μm, respectively (ANOVA, P = 0.03). Mean and all sectorial RNFL and BMO-MRW thickness values were significantly thinner in the NAION eyes vs the unaffected fellow and control eyes (P ≤ 0.00). The unaffected fellow eyes in NAION patients showed a significantly thicker average and sectorial BMO-MRW values than control eyes (P ≤ 0.02) except for the nasal sector (P = 0.09). Mean optic disc area derived from BMO analysis was not significantly different among groups (ANOVA, P = 0.86).

Conclusions:
The fellow unaffected eyes in patients with NAION showed significantly thicker mean peripapillary and macular choroidal and BMO-MRW thicknesses than disease-free control eyes. No differences in the mean optic disc area were found. Both a thick peripapillary choroid and a thick neuroretinal rim might contribute to the development of NAION or possibly be a secondary phenomenon.
Practices of subjectivity: the informal economies and the subaltern rebellion
Authors: Saitta Pietro 
Published: September 2017

PurposeThe purpose of this paper is to explore the links between “informal economies” and the concept of “resistance.” The author argues that the petty illegalities of the dominated and subaltern classes should be seen in their connections to the illegalism of the élites and the state. Within this framework, the informal economy is seen as both the outcome of a set of material conditions aiming at the subordinated inclusion of entire classes of citizens, and the mark of the willingness by these same subalterns to evade the bonds imposed on them by the legislations and the social hierarchies.Design/methodology/approachA review of the ethnographical and socio-economical literature on the issue of informality, accompanied byex-postreflections on pertinent studies conducted in the past by the researcher.FindingsAgainst the dominant public rhetoric, the informal economy is here seen as a particular space of enactment by the dominated and subalterns aimed at self-producing paradoxical forms of inclusion within social contexts characterized by barriers to access integration within mainstream society. It is argued that in consideration of the power relations that structure the “field,” researchers themselves become part of the struggle counterpoising individuals and institutions, and should thus make a choice among the clashing parties.Originality/valueThe paper draws on a vast body of literature that appears to go in the same direction. However, it radicalizes the instances proposed by previous authors and studies, and draws conclusions concerning the nature of the object and the ethics of research, that are opposed to the prevalent approaches to the subject.
Letter: the potential risk of HBV reactivation in patients with resolved HBV infection during direct‐acting antiviral therapy
Authors: Huang R. , Wang J. , Hao Y. , Yan X. , Wu C. 
Published: September 2017

Linked ContentThis article is linked to Mücke et al papers. To view these articles visit https://doi.org/10.1111/apt.14259 and https://doi.org/10.1111/apt.14177.
Identification of sialyl oligosaccharides including an oligosaccharide nucleotide in colostrum of an addax (Addax nasomaculatus) (Subfamily Antelopinae)
Authors: Ganzorig Khuukhenbaatar , Asakawa Takuya , Sasaki Masashi , Saito Tadao , Suzuki Isao , Fukuda Kenji , Urashima Tadasu 
Published: September 2017

AbstractMammalian milk/colostrum usually contains milk oligosaccharides along with the predominant lactose. Although milk oligosaccharides of a variety of Bovidae species including cow, sheep and goat have been characterized, those of the addax, an Antelopinae species of the Bovidae, have not as yet been clarified. In this study, several sialyl oligosaccharides were purified from a sample of addax colostrum and characterized as follows: Neu5Ac(α2‐8)Neu5Ac(α2‐3)Gal(β1‐4)Glc, Neu5Gc(α2‐8)Neu5Gc(α2‐3)Gal(β1‐4)Glc, Neu5Ac(α2‐3)Gal(β1‐4)Glc, Neu5Ac(α2‐6)Gal(β1‐4)GlcNAc, Neu5Gc(α2‐3)Gal(β1‐4)Glc, Neu5Gc(α2‐6)Gal(β1‐4)Glc, Neu5Gc(α2‐6)Gal(β1‐4)GlcNAc. In addition, an oligosaccharide nucleotide Neu5Gc(α2‐6)Gal(β1‐4)GlcNAcα1‐UDP was characterized. Molecular species of a variety of sialyl oligosaccharides found in milk and colostrum of these Bovidae were compared.
Exploratory and descriptive study on nutritional characteristics and quality of eggs from Chilean partridge (Nothoprocta perdicaria)
Authors: Arias José Luis , Matthei Alberto , Valenzuela Carolina 
Published: September 2017

ABSTRACTThis work aims to contribute more information on tinamou eggs by performing an exploratory and descriptive study of some of their nutritional and quality characteristics. The chemical composition of tinamou egg showed a high protein content in white (85% dry basis) and high lipid concentration in yolk (52% db). The iron (Fe) content in white was higher than hen egg (0.47 mg/100 g) and this could be associated with the observed pinkish color of the white. As in the hen egg, the major fatty acids in tinamou yolk were: oleic (39%), linoleic (23%) and palmitic (20%). The cholesterol content of tinamou was 21.2 mg/g of yolk, and 100 g of whole egg provides 589 mg of cholesterol. As in the hen egg, tinamou egg white showed high levels of lysine, sulfur‐containing amino acids, threonine and valine with respect to the recommended allowance for an adult man. All essential amino acids with the exception of histidine cover the adult requirements. The shell inorganic composition of these eggs is calcium carbonate and the morphology was similar to other avian eggs. Tinamou egg is small and elongated, with a dark brown color. The eggshell is thinner and experiences more deformation but less breaking strength than hen eggshell.
Drug–drug interaction potential in men treated with enzalutamide: Mind the gap
Authors: Benoist Guillemette Emma , van Oort Inge M. , Smeenk Stella , Javad Adrian , Somford Diederik M. , Burger David M. , Mehra Niven , van Erp Nielka P. 
Published: September 2017

AimsMetastatic castration‐resistant prostate cancer (mCRPC) patients are generally older patients with several co‐morbidities and are therefore at increased risk of complications due to drug–drug interactions (DDIs). We assessed the prevalence of potential DDIs in a cohort of mCRPC patients treated with enzalutamide.MethodsWe conducted a retrospective review of pharmacy records to retrieve individual drug histories of mCRPC patients who started enzalutamide therapy in a tertiary care setting. Potential DDIs were analysed using two international drug interaction compendia: Lexicomp® and Micromedex®, and the Dutch drug database. Two potential pharmacodynamic DDIs were analysed.ResultsA total of 105 records were evaluated for potential DDIs with enzalutamide. Of 205 different co‐medications, 56 were flagged by at least one of the three compendia: Lexicomp, Micromedex and the Dutch drug database flagged for potential DDIs in 85%, 54% and 32%, respectively. Eighty‐five per cent of DDIs were classified as major. The median number of co‐medications per patient was 11 (range 1–26). The median (range) number of interactions per patient was 4 (0–10), 1 (0–5) and 0 (0–2) for Lexicomp, Micromedex and the Dutch drug database, respectively. In 23% and 45% of all patients, a potential DDI was found with PPIs and CNS depressants, respectively.ConclusionsA high prevalence of potential DDIs was found. The inclusion and grading of potential DDIs was highly variable between the three drug interaction compendia. Physicians, nurses and pharmacists should be aware of this potential problem, which might require intensive monitoring or alternative treatment strategies to prevent suboptimal treatment of the co‐morbidities in patients treated with enzalutamide.
Temporal resolutions in species distribution models of highly mobile marine animals: Recommendations for ecologists and managers
Authors: Mannocci Laura , Boustany Andre M. , Roberts Jason J. , Palacios Daniel M. , Dunn Daniel C. , Halpin Patrick N. , Viehman Shay , Moxley Jerry , Cleary Jesse , Bailey Helen , Bograd Steven J. , Becker Elizabeth A. , Gardner Beth , Hartog Jason R. , Hazen Elliott L. , Ferguson Megan C. , Forney Karin A. , Kinlan Brian P. , Oliver Matthew J. , Perretti Charles T. , Ridoux Vincent , Teo Steven L. H. , Winship Arliss J. 
Published: September 2017

AbstractWhile ecologists have long recognized the influence of spatial resolution on species distribution models (SDMs), they have given relatively little attention to the influence of temporal resolution. Considering temporal resolutions is critical in distribution modelling of highly mobile marine animals, as they interact with dynamic oceanographic processes that vary at time‐scales from seconds to decades. We guide ecologists in selecting temporal resolutions that best match ecological questions and ecosystems, and managers in applying these models. We group the temporal resolutions of environmental variables used in SDMs into three classes: instantaneous, contemporaneous and climatological. We posit that animal associations with fine‐scale and ephemeral features are best modelled with instantaneous covariates. Associations with large scale and persistent oceanographic features are best modelled with climatological covariates. Associations with mesoscale features are best modelled with instantaneous or contemporaneous covariates if ephemeral processes are present or interannual variability occurs, and climatological covariates if seasonal processes dominate and interannual variability is weak.
Model‐based mapping of assemblages for ecology and conservation management: A case study of demersal fish on the Kerguelen Plateau
Authors: Hill Nicole A. , Foster Scott D. , Duhamel Guy , Welsford Dirk , Koubbi Philippe , Johnson Craig R. 
Published: September 2017

AbstractAimQuantifying biological assemblages and their environment is a fundamental, yet statistically challenging task in conservation ecology. Here, we use a recently developed approach called Regions of Common Profile (RCP) to quantify and map the distribution of demersal fish assemblages in an ecologically significant region of the Southern Ocean to (1) gain ecological and management insights and (2) evaluate the utility of the new method for ecoregionalization.LocationNorthern Kerguelen Plateau, Subantarctic Islands, Southern Ocean.MethodsThe RCP approach is a multispecies, model‐based approach that can overcome many limitations of traditional distance‐based approaches. It simultaneously groups sites with a similar composition of species and describes the patterns of variation in assemblages using environmental data, allowing the prediction of assemblages across the study region. We apply RCP to a unique dataset of demersal fish occurrences across the northern Kerguelen Plateau to model and map the distribution of assemblages and examine the representativeness of the Heard Island and McDonald Island marine reserve.ResultsWe demonstrate that the RCP approach allows a direct and quantitative interpretation of the composition of assemblages as well as their environment. Further, the model reasonably predicts the occurrence of individual species across the plateau as well as the species composition of sites. We distinguish and map seven assemblages defined by depth, surface temperature and chlorophyll a. Shallow‐water assemblages contain a high proportion of endemic species, while deep‐water assemblages contain more cosmopolitan species. With the exception of one deep‐water assemblage, assemblages were well represented within the current Heard and McDonald Islands marine reserve.Main conclusionsThe RCP is a valuable tool for classifying biological regions with a range of ecological and conservation management applications. Our results extend current ecological and biogeographic knowledge for the northern Kerguelen Plateau, and maps of the distribution of assemblages will be useful for ongoing spatial management.
Soil ecotoxicity of seven endocrine‐disrupting chemicals: a review
Authors: Kwak J. I. , Moon J. , Kim D. , An Y.‐J. 
Published: September 2017

Endocrine‐disrupting chemicals (EDCs) are widely used in manufacturing, and they enter the soil by direct and indirect pathways. Thus, there are concerns about their potential effects on soil ecosystems and some studies have monitored EDCs in the soil environment. However, there have been few studies on soil ecotoxicity of EDCs so far compared with aquatic ecotoxicity, and there is no comprehensive review of soil ecotoxicity of EDCs. Therefore, we collected, compiled and reviewed 77 studies on the soil ecotoxicity of seven prominent EDCs: bisphenol A, di(2‐ethylhexyl) phthalate (DEHP), nonylphenols, triclosan, polybrominated diphenyl ethers (PBDEs), perfluorooctanoic acid (PFOA) and perfluorooctane sulphonate (PFOS). This review brings together the data on soil ecotoxicity and research trends for these seven EDCs and identifies the need for further research to fill the gaps in our knowledge and data.Highlights

Endocrine‐disrupting chemicals (EDCs) pose potential threats to soil ecosystems.
Seventy‐seven studies on the soil ecotoxicity of seven EDCs were reviewed.
There are fewer studies on soil ecotoxicity than on aquatic ecotoxicity.
Further research including various environmentally relevant concentrations of EDCs is needed.
Ranibizumab in patients with neovascular age‐related macular degeneration: results from the real‐world LUMINOUS™ study
Authors: Souied E. , Clemens A. , Macfadden W. 
Published: September 2017

PurposeLUMINOUS(NCT01318941) was designed to evaluate the long‐term safety, effectiveness, and treatment patterns with ranibizumab 0.5 mg in clinical practice across all licensed indications. We report, the effectiveness and safety of ranibizumab treatment in patients with neovascular age‐related macular degeneration (nAMD) from the final analysis of LUMINOUS.MethodsLUMINOUS is a recently‐completed, 5‐year, global, observational study. Consenting adult patients were treated as per the local ranibizumab label. Reported are the 1‐year visual acuity (VA, primary treated eye), and injection pattern for the treatment‐naïve nAMD patients. The incidence of adverse events (AEs) and serious AEs (SAEs) for the total treatment‐naïve nAMD cohort is also presented.ResultsBaseline and 1‐year VA data were available for 2701 treatment‐naïve nAMD patients. At baseline, the mean (SD) age was 75.9 (9.7) years, 58.4% were female, and 78.4% were Caucasian. VA (letters) gains at 1‐year in treatment‐naïve patients receiving <3, 3–6, and >6 injections were 2.1 (n = 372), 3.6 (n = 1499), and 4.3 (n = 830), from baseline of 45.0, 52.5, and 54.9, respectively. In all treatment‐naïve nAMD patients, the mean (SD) gain in VA of 3.6 (16.2) at 1 year from 52.2 (20.8) at baseline was achieved with a mean (SD) of 5.3 (2.7) ranibizumab injections and 9.3 (3.3) monitoring visits. Across all treatment‐naïve nAMD patients (n = 6241), the incidence of ocular/non‐ocular AEs and SAEs were 8.2%/12.8% and 0.9%/7.4%, respectively.ConclusionsThis analysis from LUMINOUS confirms the effectiveness of ranibizumab in treatment‐naïve nAMD, and shows a relationship between VA improvement and the number of ranibizumab injections each patient received.
Changes of anterior chamber morphometry with age in children using hand‐held spectral domain optical coherence tomography
Authors: Edawaji B. , Proudlock F. , Gottlob I. 
Published: September 2017

PurposeTo identify the change of anterior chamber measurements with age in children using Hand‐Held Spectral Domain Optical Coherence Tomography (HH‐SDOCT).MethodsA cross‐sectional study involved 93 normal children (mean age = 5.19 ± 4.1 years, range: 2 days to 15 years). HH‐SDOCT (Leica Microsystems Ltd) was used to image anterior chamber angle. B‐scan showing both clear nasal and temporal angles were analysed using ImageJ. The iridocorneal angle landmarks: scleral spur (SS), Schwalbe`s line (SL) and angle recess (AR) were identified and used to calculate trabecular meshwork length (TML), scleral spur angle opening distance (SSAOD), Schwalbe`s line angle opening distance (SLAOD), trabecular iris surface area (TISA), TISA500, SS limbal distance (SSLD) and SL limbal distance (SLLD), nasal SS to temporal SS distance (SS‐SSD), nasal SL to temporal SL distance (SL‐SLD) and pupil diameter (PD). Linear mixed models were used to determine the correlation between ocular parameters and demographic data with log age.ResultsAll measured parameters were significantly influenced by age (all P values <0.05). The changes of parameters per age were measured in 591 angle images. In the first year, TML increased by 159.6 μm (30.5%), SSAOD 120.4 μm (112.4%), SLAOD 347.4 μm (95.7%), TISA 0.19 mm² (133.4%), TISA500 0.13 mm² (96.4%), SSLD 33.7 μm (4.2%), SLLD ‐ 30.3 μm (3.9%), SS‐SSD 2.4 mm (23.3%), SL‐SLD 2.0 mm (21.4%) and PD 2.4 mm (114.3%). No significant changes were detected with gender or between both eyes (P values > 0.05).ConclusionsHH‐SDOCT can be an effective technique in understanding the morphometric changes of anterior chamber in children from birth. Our findings highlight the need for normative age adjusted data to detect abnormalities in angle measures clinically.
Laboratory work‐up and specialized investigations
Authors: khairallah M. , Khochtali S. , Jelliti B. 
Published: September 2017

SummaryMaking the correct diagnosis of a specific uveitic entity is critical to appropriate management. The likely diagnosis can be derived from medical history, anatomic type and clinical characteristics of uveitis, and results of ocular imaging in selected cases. Laboratory testing then is performed to look for an infectious cause or an underlying systemic disease, that cannot be identified on a clinical basis. A comprehensive work‐up is costly and unnecessary. It may also give misleading positive results. Laboratory investigations should rather be tailored to epidemiological data and clinical findings. In cases of suspected intraocular infections, intraocular fluids may be evaluated for specific antibody production or polymerase chain testing. In case of negative history and absence of findings suggestive of a particular diagnosis, a minimal work‐up should be performed, including complete blood count, erythrocvyte sedimentation rate, Mantoux test, interferon‐gamma release assay, chest X‐ray, and serology of syphilis. A more extensive work‐up may be required in cases of severe uveitis, recurrences, resistance to treatment or worsening under therapy.
Therapeutic management of uveitis
Authors: Dick A. 
Published: September 2017

SummaryThis talk will overview the contemporary therapeutic approaches to treatment of noninfectious non‐infective ocular inflammatory disease. Treatment of non‐infectious uveitis has over past 15 years expanded from the use of traditional therapies including corticosteroids and immunosuppressants to the deployment of targetting the immuneresponse with biologic therapies with monoclonal antibodies and immunoadhesins. Such use will be exemplified with case reports during the talk. Evidence of efficacy of immunosuppressants in the treatment of uveitis, the role of predicting steroid responsiveness, the use of monotherapy with immunosuppression and finally the pathways and evidence of success of biologic therapy will be provided.