bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010–2013
Authors: Janow Ginger , Schanberg Laura E. , Setoguchi Soko , Hasselblad Victor , Mellins Elizabeth D. , Schneider Rayfel , Kimura Yukiko ,   CARRA Legacy Registry Investigators
Published: June 2016

Objective.We aimed to identify the (1) demographic/clinical characteristics, (2) medication usage trends, (3) variables associated with worse disease activity, and (4) characteristics of patients with persistent chronic arthritis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry’s systemic juvenile idiopathic arthritis (sJIA) cohort.Methods.Demographics, disease activity measures, and medications at enrollment of patients with sJIA in the CARRA Registry were analyzed using descriptive statistics. Multivariate analyses were conducted to identify associations with increased disease activity. Medication usage frequencies were calculated by year.Results.There were 528 patients with sJIA enrolled in the registry (2010–2013). There were 435 patients who had a complete dataset; of these, 372 met the International League of Associations for Rheumatology criteria and were included in the analysis. At enrollment, median disease duration and joint count were 3.7 years and 0, respectively; 16.4% had a rash and 6.7% had a fever. Twenty-six percent were taking interleukin 1 (IL-1) inhibitors and 29% glucocorticoids. Disease-modifying antirheumatic drugs and tumor necrosis factor inhibitors use decreased, while IL-6 inhibitor use increased between 2010 and 2013. African American patients had worse joint counts (p = 0.003), functional status (p = 0.01), and physician’s global assessment (p = 0.008). Of the 255 subjects with > 2 years of disease duration, 56% had no arthritis or systemic symptoms, while 32% had persistent arthritis only.Conclusion.Most patients in the largest sJIA cohort reported to date had low disease activity. Practice patterns for choice of biologic agents appeared to change over the study period. Nearly one-third had persistent arthritis without systemic symptoms > 2 years after onset. African Americans were associated with worse disease activity. Strategies are needed to improve outcomes in subgroups with poor prognosis.
Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study
Authors: Hattori Yosuke , Kojima Toshihisa , Kaneko Atsushi , Kida Daihei , Hirano Yuji , Fujibayashi Takayoshi , Terabe Kenya , Yabe Yuichiro , Miyake Hiroyuki , Kato Takefumi , Takagi Hideki , Hayashi Masatoshi , Ito Takayasu , Kanayama Yasuhide , Oguchi Takeshi , Takahashi Nobunori , Ishikawa Hisato , Funahashi Koji , Ishiguro Naoki 
Published: June 2016

Objective.To evaluate the rates of retention and discontinuation of adalimumab (ADA) due to efficacy and safety in Japanese patients with rheumatoid arthritis (RA).Methods.All patients with RA (n = 476) who were treated with ADA in the Tsurumai Biologics Communication Registry were enrolled.Results.The retention rate of ADA was 46% at 5 years. When focusing on insufficient efficacy, previous biologics use and high baseline disease activity were significant risk factors for up to 1 year. Methotrexate (MTX) use was a significantly low risk factor after 1 year of treatment.Conclusion.Concomitant MTX contributes to the longterm efficacy of ADA therapy.
Efficacy of Subcutaneous Secukinumab in Patients with Active Psoriatic Arthritis Stratified by Prior Tumor Necrosis Factor Inhibitor Use: Results from the Randomized Placebo-controlled FUTURE 2 Study
Authors: Kavanaugh Arthur , McInnes Iain B. , Mease Philip J. , Hall Stephen , Chinoy Hector , Kivitz Alan J. , Wang Zailong , Mpofu Shephard 
Published: June 2016

Objective.To determine the effect of prior tumor necrosis factor inhibitor (TNFi) therapy on secukinumab efficacy in psoriatic arthritis (PsA).Methods.Patients were randomized to secukinumab 300 mg, 150 mg, 75 mg, or placebo.Results.American College of Rheumatology 20 responses at Week 24 with secukinumab 300 mg, 150 mg, 75 mg, and placebo were 58.2%, 63.5%, 36.9%, and 15.9% in TNFi-naive (n = 258), and 45.5%, 29.7%, 14.7%, and 14.3% in TNFi-exposed patients (n = 139), respectively. Week 52 responses with secukinumab 300 mg, 150 mg, and 75 mg were 68.7%, 79.4%, and 58.5% in TNFi-naive, and 54.5%, 37.8%, and 35.3% in TNFi-exposed patients, respectively.Conclusion.Secukinumab was efficacious in TNFi-naive and TNFi-exposed patients with PsA, with greatest improvements in TNFi-naive patients.
Quand le paysage prend corps : l’imaginaire kinesthésique dans la réception d’ Une barque sur l’océan de Maurice Ravel
Authors: Spampinato Francesco 
Published: June 2016

Dans l’histoire de la réception d’ Une barque sur l’océan de Maurice Ravel, des lectures apparemment très différentes coexistent. L’on a tantôt décrit cette pièce comme l’on regarderait à distance un spectacle visuel, alors que d’autres ont évoqué un conflit physique et une implication émotionnelle intense. Cet article tente alors d’étudier ces contradictions apparentes en présentant d’abord les résultats du projet Métakinésis2, qui consistait à mettre en place des expériences d’écoute et à recueillir les témoignages verbaux des auditeurs. En nous appuyant sur un modèle sémiotique, nous avons retrouvé dans l’écriture musicale de Ravel les éléments susceptibles d’inviter un sujet à adopter tel ou tel imaginaire d’écoute. Il a été ainsi possible de reconnaitre les correspondances entre les évocations spontanées des auditeurs et celles que critiques et musicologues ont suggérées tout au long de l’histoire de la réception de cette pièce.
La modernisation du porte-à-porte au Parti socialiste. Réinvention d’un répertoire de campagne et inerties militantes
Authors: Lefebvre Rémi 
Published: June 2016

Le PS a engagé lors de l’élection présidentielle de 2012 une campagne de porte-à-porte d’une ampleur et d’une forme inédites. Ce dispositif est le produit de la mobilisation de trois jeunes militants ayant participé à la campagne de B. Obama en 2008 et contribué à leur diffusion en France. Ces réformateurs imposent une méthode de porte-à-porte en rupture avec les usages pragmatiques, intuitifs et bricolés de cette technique traditionnelle. Ils sont porteurs d’une conception rationalisée du porte-à-porte qui doit être selon eux « managée », systématisée, ciblée, standardisée et quantifiée. L’article analyse cette entreprise de rationalisation et de managérialisation du porte-à-porte en s’attachant aux raisons de son « succès » mais aussi aux limites qu’elle rencontre.
Treatment of Macular Telangiectasia Type 2 With Carotenoid Supplements Containing Meso-Zeaxanthin: A Pilot Study
Authors: Tan Anna C.S. , Balaratnasingam Chandrakumar , Yannuzzi Lawrence A. 
Published: June 2016

BACKGROUND AND OBJECTIVE:
To assess the outcomes of patients with macular telangiectasia type 2 (MacTel 2) in response to lutein (L), meso-zeaxanthin (M), and zeaxanthin (Z) supplements (LMZ3).

PATIENTS AND METHODS:
Thirteen patients diagnosed with MacTel 2 were started on lutein 10 mg, meso-zeaxanthin 10 mg, and zeaxanthin 2 mg and were followed-up for a mean period of 15.7 months ± 4.85 months.

RESULTS:

Visual acuity improved in three patients (13%), and there was a reduction in the percentage of patients who had worsening vision (25% to 4%;
P
< .05). Optical coherence tomography changes showed a reduction in the number of cavitations and the largest diameter of the cavitation after the LMZ3 supplements were started. The largest diameter of photoreceptor disruption showed mild improvement in the first 6 months after LMZ3 supplements were started.

CONCLUSION:
LMZ3 supplements may stabilize vision and improve the cavitations in patients with MacTel 2. Larger randomized, controlled studies are required to verify these pilot results.

[
Ophthalmic Surg Lasers Imaging Retina
. 2016;47:528–535.]
An Inhibitor of the Alternative Pathway of Complement in Saliva of New World Anopheline Mosquitoes
Authors: Mendes-Sousa Antonio F. , Queiroz Daniel C. , Vale Vladimir F. , Ribeiro José M. C. , Valenzuela Jesus G. , Gontijo Nelder F. , Andersen John F. 
Published: June 2016

AbstractThe complement system present in circulating blood is an effective mechanism of host defense, responsible for the killing of pathogens and the production of potent anaphylatoxins. Inhibitors of the complement system have been described in the saliva of hematophagous arthropods that are involved in the protection of digestive tissues against complement system–mediated damage. In this study, we describe albicin, a novel inhibitor of the alternative pathway of complement from the salivary glands of the malaria vector, Anopheles albimanus. The inhibitor was purified from salivary gland homogenates by reverse-phase HPLC and identified by mass spectrometry as a small (13.4-kDa) protein related to the gSG7 protein of Anopheles gambiae and Anopheles stephensi. Recombinant albicin was produced in Escherichia coli and found to potently inhibit lysis of rabbit erythrocytes in assays of the alternative pathway while having no inhibitory effect on the classical or lectin pathways. Albicin also inhibited the deposition of complement components on agarose-coated plates, although it could not remove previously bound components. Antisera produced against recombinant albicin recognized both the native and recombinant inhibitors and also blocked their activities in in vitro assays. Using surface plasmon resonance and enzymatic assays, we found that albicin binds and stabilizes the C3-convertase complex (C3bBb) formed on a properdin surface and inhibits the convertase activity of a reconstituted C3bBb complex in solution. The data indicate that albicin specifically recognizes the activated form of the complex, allowing more efficient inhibition by an inhibitor whose quantity is limited.
The Psychology of Cosplay
Authors: Geczy Adam 
Published: June 2016

Abstract
“The Psychology of Cosplay” seeks to explore the psychological motivation and structure of cosplay as distinct from general masquerade as it emerged from the late sixteenth century. While it is no doubt a form of othering, the key difference is the situating of the subject. In conventional masquerade there is still a locatable difference between self and costume, and self and myth. With cosplay, by distinction, there is no discernible myth, only a multitude or surfeit of myths. This requires ordering and rules in order for the illusion of sense to reign. As opposed to conventional masquerade which is to mobilize a certain erotic disorder, cosplay involves a disavowal of the subject, a self-nihilation, in order to give birth to the new other. As such cosplay ritualizes the posthumanist subject.
Fashionable Dunedin and “Rooted Cosmopolitanism” in the Twenty-First Century: NOM*d and Company of Strangers
Authors: Radner Hilary 
Published: June 2016

Abstract
Typically, fashion has been associated with the large urban centers that are considered the hubs of contemporary culture, or “fashion’s world cities,” to borrow from the title of an oft-quoted edited volume; however, in the twenty-first century, fashion may play a role at a local or regional level, even in relatively isolated contexts such as that provided by Dunedin, located in New Zealand, at the bottom of the South Island. The work of Dunedin designers such as Margarita Robertson and Sara Munro, creative directors for their respective clothing lines, NOM*d and Company of Strangers, illustrates Walter Benjamin’s conceptualization of fashion as expressing utopian desires, in this case a form of “rooted cosmopolitanism,” to borrow from Kwame Anthony Appiah, while furthering an economic system dependent on commodity fetishism.
Robotic prostatectomy is associated with increased patient travel and treatment delay
Authors: Maurice Matthew J. , Zhu Hui , Kim Simon P. , Abouassaly Robert 
Published: June 2016

Introduction: New technologies may limit access to treatment. We investigated radical prostatectomy (RP) access over time since robotic introduction and the impact of robotic use on RP access relative to other approaches in the modern era.Methods: Using the National Cancer Data Base, RPs performed during the eras of early (2004‒2005) and late (2010‒2011) robotic dissemination were identified. The primary endpoints, patient travel distance and treatment delay, were compared by era, and for 2010‒2011, by surgical approach. Analyses included multivariable and multinomial logistic regression.Results: 138 476 cases were identified, 32% from 2004‒2005 and 68% from 2010‒2011. In 2010‒2011, 74%, 21%, and 4.3% of RPs were robotic, open, and laparoscopic, respectively. Treatment in 2010‒2011 and robotic approach were independently associated with increased patient travel distance and longer treatment delay (p<0.001). Men treated robotically had 1.1‒1.2 times higher odds of traveling medium-to-long-range distances and 1.2‒1.3 higher odds of delays 90 days or greater compared to those treated open (p<0.001). Laparoscopic approach was associated with increased patient travel and treatment delay, but to a lesser extent than the robotic approach (p<0.001). In high-risk patients, treatment delays remained significantly longer for minimally invasive approaches (p<0.001). Other factors associated with the robotic approach included referral from an outside facility, treatment at an academic or high-volume hospital, higher income, and private insurance. Potential limitations include the retrospective observational design and lack of external validation of the primary outcomes.Conclusions: The robotic approach is associated with increased travel burden and treatment delay, potentially limiting access to surgical care.
Human Resource Management Outsourcing Decision for Small and Medium-sized Enterprises in China
Authors: Chu Jing 
Published: June 2016

<p>Human resource management (HRM) plays an important role in every enterprise. Nowadays, in China, more and more enterprises, not only large companies, but also small and medium-sized enterprises (SMEs) choose to outsource their HRM activities for economic and strategic benefits. According to the feature of HRM in SMEs, this paper builds a more systematic and practical human resource management outsourcing decision model for SMEs. In this decision model, HRM activities are classified into transaction, profession and strategy levels, and economic benefit, core competence enhancement and risks are taken into consideration. Applying multi-objective intelligent weighted grey target decision method based on combination weighting approach, the decision model can help the enterprise decide which HRM activities should be outsourced in priority sequence. The study proposes a scientific guidance for China’s SMEs to make the HRM outsourcing decision. </p>
Legal Constraints on the Indeterminate Control of ‘Dangerous’ Sex Offenders in the Community: The English Perspective
Authors: Padfield Nicola 
Published: June 2016

Legal Constraints on the Indeterminate Control of ‘Dangerous’ Sex Offenders in the Community: The English Perspective
This article explores the legal constraints imposed on the rising number of so-called ‘dangerous’ sex offenders in England and Wales, in particular once they have been released from prison into the community. The main methods of constraint are strict licence conditions, Multi-Agency Public Protection Arrangements and civil protective orders such as Sexual Harm Prevention Orders. ‘Control’ in the community is thus widespread, but is difficult to assess whether it is either effective or necessary without a great deal more research and analysis. Post-sentence ‘punishment’ has been largely ignored by both academic lawyers and criminologists. The article concludes that financial austerity might prove to be as important as the human rights agenda in curbing the disproportionate use of powers of control.
Crossover between fast and slow excitation of magnetization by spin torque
Authors: Taniguchi Tomohiro 
Published: June 2016

Abstract
A crossover between two mechanisms destabilizing the magnetization in equilibrium by the spin transfer effect is found in a ferromagnetic multilayer consisting of an in-plane magnetized free layer and a perpendicularly magnetized pinned layer, where an in-plane magnetic field is applied, and electric current flows from the pinned to the free layer. A fast transition from the in-plane to the out-of-plane state occurs in the low-field region, whereas a slow transition with small-amplitude oscillation becomes dominant in the high-field region. On the other hand, only the fast transition mechanism appears for the opposite current direction.
Utilizing mutual information for detecting rare and common variants associated with a categorical trait
Authors: Sun Leiming , Wang Chan , Hu Yue-Qing 
Published: June 2016

Background.Genome-wide association studies have succeeded in detecting novel common variants which associate with complex diseases. As a result of the fast changes in next generation sequencing technology, a large number of sequencing data are generated, which offers great opportunities to identify rare variants that could explain a larger proportion of missing heritability. Many effective and powerful methods are proposed, although they are usually limited to continuous, dichotomous or ordinal traits. Notice that traits having nominal categorical features are commonly observed in complex diseases, especially in mental disorders, which motivates the incorporation of the characteristics of the categorical trait into association studies with rare and common variants.Methods.We construct two simple and intuitive nonparametric tests, MIT and aMIT, based on mutual information for detecting association between genetic variants in a gene or region and a categorical trait. MIT and aMIT can gauge the difference among the distributions of rare and common variants across a region given every categorical trait value. If there is little association between variants and a categorical trait, MIT or aMIT approximately equals zero. The larger the difference in distributions, the greater values MIT and aMIT have. Therefore, MIT and aMIT have the potential for detecting functional variants.Results.We checked the validity of proposed statistics and compared them to the existing ones through extensive simulation studies with varied combinations of the numbers of variants of rare causal, rare non-causal, common causal, and common non-causal, deleterious and protective, various minor allele frequencies and different levels of linkage disequilibrium. The results show our methods have higher statistical power than conventional ones, including the likelihood based score test, in most cases: (1) there are multiple genetic variants in a gene or region; (2) both protective and deleterious variants are present; (3) there exist rare and common variants; and (4) more than half of the variants are neutral. The proposed tests are applied to the data from Collaborative Studies on Genetics of Alcoholism, and a competent performance is exhibited therein.Discussion.As a complementary to the existing methods mainly focusing on quantitative traits, this study provides the nonparametric tests MIT and aMIT for detecting variants associated with categorical trait. Furthermore, we plan to investigate the association between rare variants and multiple categorical traits.
Role of ocean evaporation in California droughts and floods
Authors: Wei Jiangfeng , Jin Qinjian , Yang Zong‐Liang , Dirmeyer Paul A. 
Published: June 2016

AbstractSince winter 2011, a record‐breaking drought has occurred in California. Studies found that the drought is mainly caused by a persistent high‐pressure system off the U.S. West Coast, which is linked to Pacific sea surface temperature anomalies. The water cycles associated with the droughts and floods are still not clearly understood. Here we show that the atmospheric circulation off the West Coast not only controls the atmospheric convergence and formation of precipitation but also largely determines surface wind speed, which further affects the evaporation over the eastern North Pacific, the major evaporative moisture source for California precipitation. Because of this mechanism, the ocean evaporation over the eastern North Pacific has been reduced during the recent drought. However, the ocean evaporation anomalies have little direct influence on California precipitation, especially during dry years, mainly because of their weak amplitudes. The California droughts cannot be readily attributed to the reduced ocean evaporation. The association between increased Pacific evaporation and floods over California is somewhat stronger.
Receiver structure from teleseisms: Autocorrelation and cross correlation
Authors: Sun Weijia , Kennett B. L. N. 
Published: June 2016

AbstractWe present a way of characterizing the structure beneath a seismic station, by exploiting stacked correlograms of three‐component records from teleseismic events. This seismic daylight imaging approach exploits the extraction of reflection and conversion information from teleseismic coda via tensor autocorrelation. The approach is illustrated for a number of Australian stations in a variety of tectonic environments using hundreds of teleseismic events, to extract P and S reflectivity and converted Ps and Sp information. The results show a very good agreement with prior knowledge across Australia. Compared with the classical receiver function, the broader‐frequency band of 0.5–4.0 Hz provides additional information on finer‐scale structure.
On how spatial variations of channel width influence river profile curvature
Authors: Ferrer‐Boix Carles , Chartrand Shawn M. , Hassan Marwan A. , Martín‐Vide Juan P. , Parker Gary 
Published: June 2016

AbstractLongitudinal profiles of alluvial rivers usually exhibit upward‐concave curvatures at equilibrium. River profile concavity has been primarily attributed to sediment downstream fining and to streamwise increments of water discharge. Conversely, upward‐convex profiles have been typically associated with tectonic and geologic controls and with outlet base‐level drops. Equations to describe river profiles at equilibrium developed from mass conservation principles do not consider longitudinal changes in channel width. This study addresses how variations in channel width can also act to control the curvature of longitudinal profiles. We develop a new theoretical framework in which the role on river profiles of downstream variations of channel width, flow discharge, bed roughness, and surface texture are explicitly shown. Unlike classical approaches for river profile evolution, this novel framework identifies physical domains for rivers to develop upward‐concave/convex longitudinal profiles depending on channel width and flow discharge gradients flow intensity and surface texture.