bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population Survey Features and Response Rates: A Randomized Experiment
Authors: Guo Yimeng , Kopec Jacek A. , Cibere Jolanda , Li Linda C. , Goldsmith Charles H. 
Published: May 2016

Objectives. To study the effects of several survey features on response rates in a general population health survey. Methods. In 2012 and 2013, 8000 households in British Columbia, Canada, were randomly allocated to 1 of 7 survey variants, each containing a different combination of survey features. Features compared included administration modes (paper vs online), prepaid incentive ($2 coin vs none), lottery incentive (instant vs end-of-study), questionnaire length (10 minutes vs 30 minutes), and sampling frame (InfoCanada vs Canada Post). Results. The overall response rate across the 7 groups was 27.9% (range = 17.1–43.4). All survey features except the sampling frame were associated with statistically significant differences in response rates. The survey mode elicited the largest effect on the odds of response (odds ratio [OR] = 2.04; 95% confidence interval [CI] = 1.61, 2.59), whereas the sampling frame showed the least effect (OR = 1.14; 95% CI = 0.98, 1.34). The highest response was achieved by mailing a short paper survey with a prepaid incentive. Conclusions. In a mailed general population health survey in Canada, a 40% to 50% response rate can be expected. Questionnaire administration mode, survey length, and type of incentive affect response rates.
Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT
Authors: Shotwell Matthew S. , Nesbitt Ross , Madonia Phillip N. , Gould Edward R. , Connor Michael J. , Salem Charbel , Aduroja Olufemi A. , Amde Milen , Groszek Joseph J. , Wei Peilin , Taylor Maria E. , Tolwani Ashita J. , Fissell William H. 
Published: May 2016

Background and objectives
Infection is the most common cause of death in severe AKI, but many patients receiving continuous RRT do not reach target antibiotic concentrations in plasma. Extended infusion of β-lactams is associated with improved target attainment in critically ill patients; thus, we hypothesized that extended infusion piperacillin-tazobactam would improve piperacillin target attainment compared with short infusion in patients receiving continuous RRT.

Design, setting, participants, & measurements
We conducted an institutional review board–approved observational cohort study of piperacillin-tazobactam pharmacokinetics and pharmacodynamics in critically ill patients receiving continuous venovenous hemodialysis and hemodiafiltration at three tertiary care hospitals between 2007 and 2015. Antibiotic concentrations in blood and/or dialysate samples were measured by liquid chromatography, and one– and two–compartment pharmacokinetic models were fitted to the data using nonlinear mixed effects regression. Target attainment for piperacillin was defined as achieving four times the minimum inhibitory concentration of 16 μg/ml for >50% of the dosing cycle. The probabilities of target attainment for a range of doses, frequencies, and infusion durations were estimated using a Monte Carlo simulation method. Target attainment was also examined as a function of patient weight and continuous RRT effluent rate.

Results
Sixty-eight participants had data for analysis. Regardless of infusion duration, 6 g/d piperacillin was associated with ≤45% target attainment, whereas 12 g/d was associated with ≥95% target attainment. For 8 and 9 g/d, target attainment ranged between 68% and 85%. The probability of target attainment was lower at higher effluent rates and patient weights. For all doses, frequencies, patient weights, and continuous RRT effluent rates, extended infusion was associated with higher probability of target attainment compared with short infusion.

Conclusions
Extended infusions of piperacillin-tazobactam are associated with greater probability of target attainment in patients receiving continuous RRT.
Le rôle du rire dans les organisations
Authors: Bourguinat Élisabeth , Lorgnier Aurélien 
Published: May 2016

On rit beaucoup dans les organisations, en particulier quand ça ne va pas bien. C’est que le rire remplit des fonctions variées : jeux de pouvoir et d’influence, rééquilibrage de transactions inégales entre les acteurs, compensation des dysfonctionnements...
Data Lakes and Data Visualization: An Innovative Approach to Addressing the Many Challenges of Health Workforce Planning
Authors: Krause Denise D. 
Published: May 2016

Background: There are a variety of challenges to health workforce planning, but access to data is critical for effective evidence-based decision-making. Many agencies and organizations throughout Mississippi have been collecting quality health data for many years. Those data have historically resided in data silos and have not been readily shared. A strategy was developed to build and coordinate infrastructure, capacity, tools, and resources to facilitate health workforce and population health planning throughout the state.Objective: Realizing data as the foundation upon which to build, the primary objective was to develop the capacity to collect, store, maintain, visualize, and analyze data from a variety of disparate sources -- with the ultimate goal of improving access to health care.Specific aims were to:1) build a centralized data repository and scalable informatics platform,2) develop a data management solution for this platform and then,3) derive value from this platform by facilitating data visualization and analysis.Methods: We designed and constructed a managed data lake for health data from disparate sources throughout the state of Mississippi. A data management application was developed to log and track all data sources, maps and geographies, and data marts. With this informatics platform as a foundation, we use a variety of tools to visualize and analyze data.Results: Samples of data visualizations that aim to inform health planners and policymakers are presented. Many agencies and organizations throughout the state benefit from this platform.Conclusion: The overarching goal is that by providing timely, reliable information to stakeholders, Mississippians in general will experience improved access to quality care.
Visualizing the quality of partially accruing data for use in decision making
Authors: Eaton Julia , Painter Ian , Olson Donald , Lober William 
Published: May 2016

Secondary use of clinical health data for near real-time public health surveillance presents challenges surrounding its utility due to data quality issues. Data used for real-time surveillance must be timely, accurate and complete if it is to be useful; if incomplete data are used for surveillance, understanding the structure of the incompleteness is necessary. Such data are commonly aggregated due to privacy concerns. The Distribute project was a near real-time influenza-like-illness (ILI) surveillance system that relied on aggregated secondary clinical health data. The goal of this work is to disseminate the data quality tools developed to gain insight into the data quality problems associated with these data. These tools apply in general to any system where aggregate data are accrued over time and were created through the end-user-as-developer paradigm. Each tool was developed during the exploratory analysis to gain insight into structural aspects of data quality. Our key finding is that data quality of partially accruing data must be studied in the context of accrual lag—the difference between the time an event occurs and the time data for that event are received, i.e. the time at which data become available to the surveillance system. Our visualization methods therefore revolve around visualizing dimensions of data quality affected by accrual lag, in particular the tradeoff between timeliness and completion, and the effects of accrual lag on accuracy. Accounting for accrual lag in partially accruing data is necessary to avoid misleading or biased conclusions about trends in indicator values and data quality.
Agent-based computational model of the prevalence of gonococcal infections after the implementation of HIV pre-exposure prophylaxis guidelines
Authors: Escobar Erik , Durgham Ryan , Dammann Olaf , Stopka Thomas 
Published: May 2016

Recently, the first comprehensive guidelines were published for pre-exposure prophylaxis (PrEP) for the prevention of HIV infection in populations with substantial risk of infection. Guidelines include a daily regimen of emtricitabine/tenofovir disoproxil fumarate (TDF/FTC) as well as condom usage during sexual activity. The relationship between the TDF/FTC intake regimen and condom usage is not yet fully understood. If men who have sex with men (MSM,) engage in high-risk sexual activities without using condoms when prescribed TDF/FTC they might be at an increased risk for other sexually transmitted diseases (STD). Our study focuses on the possible occurrence of behavioral changes among MSM in the United States over time with regard to condom usage. In particular, we were interested in creating a model of how increased uptake of TDF/FTC might cause a decline in condom usage, causing significant increases in non-HIV STD incidence, using gonococcal infection incidence as a biological endpoint. We used the agent-based modeling software NetLogo, building upon an existing model of HIV infection. We found no significant evidence for increased gonorrhea prevalence due to increased PrEP usage at any level of sample-wide usage, with a range of 0-90% PrEP usage. However, we did find significant evidence for decreased prevalence of HIV, with a maximal effect being reached when 5% to 10% of the MSM population used PrEP. Our findings appear to indicate that attitudes of aversion, within the medical community, toward the promotion of PrEP due to the potential risk of increased STD transmission are unfounded.
De Marokkanenpaniek: de sociale constructie van ‘Marokkanen’ als folk devils
Authors: Bouabid Abdessamad 
Published: May 2016

The Moroccans panic: The social construction of Moroccans as folk devils
Since the nineties, the ‘Moroccan community’ experiences a negative group-image based on a small group of male youths who ‘stand out’ in social problems such as nuisance, crime and Islamic radicalisation. This negative group image is largely constructed through negative societal reactions in the media on incidents in which Moroccan Dutch youngsters play a prominent role. This article examines such negative societal reactions in the media on three recent incidents: the 2007 Slotervaart riots, the 2008 Gouda ‘bus incident’ and the 2010 Culemborg riots. It concludes that the societal reactions to these incidents in the media, are exaggerated, symbolise ‘the Moroccans’ as folk devils and construct them as moral and cultural Others. Finally, it concludes that these negative societal reactions to ‘Moroccans’ in Dutch media can be seen as a disproportional and misplaced, but natural reaction of a dominant cultural majority to a threat to their cultural and moral hegemony, by ‘the Moroccans’ as a social deviant minority.
Adaptation of the Support Frame of the Cooling Skids System for Use in Maritime Transport
Authors: Flis Leszek 
Published: May 2016

Abstract
The article presents calculations of the strength of a support frame Skid Cooling units used on oil rigs. The complexity of the equipment does not allow for efficient FEM modeling of such structures. It indicates how to the simplify the model so that the calculations can accepted by the American Bureau of Shipping (ABS).
Utilization of Cell-Transfer Technique for Molecular Testing on Hematoxylin-Eosin–Stained Sections: A Viable Option for Small Biopsies That Lack Tumor Tissues in Paraffin Block
Authors: Wu Howard H. , Jovonovich Stephen M. , Randolph Melissa , Post Kristin M. , Sen Joyashree D. , Curless Kendra , Cheng Liang 
Published: May 2016

Context.—
In some instances the standard method of doing molecular testing from formalin-fixed, paraffin-embedded block is not possible because of limited tissue. Tumor cell–enriched cell-transfer technique has been proven useful for performing immunocytochemistry and molecular testing on cytologic smears.

Objective.—
To establish the cell-transfer technique as a viable option for isolating tumor cells from hematoxylin-eosin (H&E)–stained slides.

Design.—
Molecular testing was performed by using the cell-transfer technique on 97 archived H&E-stained slides from a variety of different tumors. Results were compared to the conventional method of molecular testing.

Results.—
Polymerase chain reaction–based molecular testing via the cell-transfer technique was successfully performed on 82 of 97 samples (85%). This included 39 of 47 cases for EGFR, 10 of 11 cases for BRAF, and 33 of 39 cases for KRAS mutations. Eighty-one of 82 cell-transfer technique samples (99%) showed agreement with previous standard method results, including 4 mutations and 35 wild-type alleles for EGFR, 4 mutations and 6 wild-type alleles for BRAF, and 11 mutations and 21 wild-type alleles for KRAS. There was only 1 discrepancy: a cell-transfer technique with a false-negative &gt;KRAS result (wild type versus G12C).

Conclusions.—
Molecular testing performed on H&E-stained sections via cell-transfer technique is useful when tissue from cell blocks and small surgical biopsy samples is exhausted and the only available material for testing is on H&E-stained slides.
Outcomes of Primary Unilateral Cheiloplasty in Same-Day Surgical Settings
Authors: Khan Mansoor , Ullah Hidayat , Aziz Asif , Tahir Muhammad 
Published: May 2016

Background Financial, clinical, and psychological considerations have made same-day surgery an attractive option for a variety of procedures. This article aimed to analyse the postoperative results of same-day primary unilateral cleft nasolabial repair.
Methods This study was performed from 2011 to 2014. Unilateral cleft lip patients fulfilling the inclusion criteria were preoperatively classified as mild, moderate, and severe. All patients underwent same-day surgery and were discharged after satisfying the appropriate clinical criteria, receiving thorough counselling, and the establishment of a means of communication by phone. Postoperative outcomes were assessed and stratified according to preoperative severity and the type of repair.
Results A total of 423 primary unilateral cleft lip patients were included. Fisher's anatomical subunit approximation technique was the most common procedure, followed by Noordhoff's technique. The postoperative outcome was good in 89.8% of cases, fair in 9.9% of cases, and poor in 0.2% of cases. The complication rate was 1.18% (n=5), and no instances of mortality were observed. The average hospital stay was 7.5 hours, leading to a cost reduction of 19% in comparison with patients who stayed overnight for observation.
Conclusions Mild unilateral cleft lip was the most common deformity for which Fisher's anatomical subunit approximation technique was performed in most of the cases, with satisfactory postoperative outcomes. Refinements in the cleft rhinoplasty techniques over the course of the study improved the results regarding cleft nasal symmetry. Single-day primary unilateral cleft cheiloplasty was found to be a cost-effective procedure that did not pose an additional risk of complications.
Orofacial Soft Tissue Reconstruction with Locoregional Flaps in a Health Resource-Depleted Environment: Experiences from Nigeria
Authors: Agbara Rowland , Obiadazie Athanasius Chukwudi , Fomete Benjamin , Omeje Kelvin Uchenna 
Published: May 2016

Background Reconstruction of orofacial soft tissue defects is often challenging due to functional and aesthetic demands. Despite advances in orofacial soft tissue defect reconstruction using free flaps, locoregional flaps still remain an important option, especially in health resource-depleted environments. This retrospective study highlights our experiences in oral and maxillofacial soft tissue reconstruction using locoregional flaps.
Methods A twenty-three years retrospective analysis of all patients managed in our department was undertaken. Information was sourced from patients' case notes and operating theater records. Data was analyzed using SPSS ver. 16 (SPSS Inc.) and Microsoft Excel 2007 (Microsoft).
Results A total of 77 patients underwent orofacial soft tissue defect reconstruction within the years reviewed. Males accounted for 55 (71.4%) cases and trauma was the main etiological factor in 45 (58.4%) of the patients treated. When sites of defect were considered, the lip, 27 (32.1%), was the most frequent site followed by the nose, 17 (20.2%). Forehead flap, 51 (59.3%), was the most commonly used flap. Complications noted were tumor recurrences at the recipient bed in 3 (3.9%) cases, tumor occurrence at the donor site in 1 (1.3%) case and postoperative infection in 11 (14.3%) cases.
Conclusions Locoregional flaps still have an important role in the rehabilitation of patients with orofacial soft tissue defects. They remain a vital tool in the armamentarium of the reconstructive surgeon, especially in health resource-depleted environments where advanced reconstructive techniques may not be feasible.
Electrostatic-field-enhanced photoexfoliation of bilayer benzene: A first-principles study
Authors: Uchida Kazuki , Silaeva Elena P. , Watanabe Kazuyuki 
Published: May 2016

Abstract
Photoexfoliation of bilayer benzene in an external electrostatic (dc) field is studied using time-dependent density functional theory combined with molecular dynamics. We find that the dc-field-induced force on the upper benzene in addition to the repulsive interaction between the positively charged benzene molecules induced by the laser field leads to fast athermal exfoliation. Thus, we conclude that the dc field enhances the photoexfoliation due to dc-field emission in addition to laser-assisted photoemission. The athermal exfoliation process is shown to depend crucially on the charge state of benzene molecules rather than on the excitation energy supplied by the laser.
The durability of building materials under a changing climate
Authors: Phillipson Mark C. , Emmanuel Rohinton , Baker Paul H 
Published: May 2016

Weathering of materials leads to degradation of the fabric of buildings which if left unchecked will lead to an increase in the rate, and possibly severity, of degradation. Adjustments to maintenance regimes could accommodate marginal changes to degradation rate. However, for significant increases in degradation rate, adaptations may be required. Globally, any new deterioration mechanisms are unlikely. However, in the future previously insignificant problems may start to become significant at a local level, for which there is a lack of local knowledge or experience. Adaptation in the context of existing buildings is a means to further protect the existing fabric, to consolidate performance and control the rate of deterioration. This adaptation goes beyond the scope of enhanced maintenance. For historic buildings, there will be tension between the need to conserve the building and simultaneously adapt in the face of increased climate change driven weathering. Impact studies are needed to identify priorities for adaptation by identifying the scale and impact of degradation‐related defects for the future building stock. Such studies need to be integrated with authoritative information on projected future climate. Adaptation of building design is needed to ensure new buildings consider performance in both current and future climates. A whole‐life approach to building design is needed. To achieve this building standards, building codes need to be developed which consider future climate design. Traditional vernacular styles may offer an opportunity for learning design lessons and adapting design practices that could help facilitate appropriate climate protection. WIREs Clim Change 2016, 7:590–599. doi: 10.1002/wcc.398This article is categorized under:

Assessing Impacts of Climate Change > Evaluating Future Impacts of Climate Change
Testing a four-dimensional variational data assimilation method using an improved intermediate coupled model for ENSO analysis and prediction
Authors: Gao Chuan , Wu Xinrong , Zhang Rong-Hua 
Published: May 2016

Abstract
A four-dimensional variational (4D-Var) data assimilation method is implemented in an improved intermediate coupled model (ICM) of the tropical Pacific. A twin experiment is designed to evaluate the impact of the 4D-Var data assimilation algorithm on ENSO analysis and prediction based on the ICM. The model error is assumed to arise only from the parameter uncertainty. The “observation” of the SST anomaly, which is sampled from a “truth” model simulation that takes default parameter values and has Gaussian noise added, is directly assimilated into the assimilation model with its parameters set erroneously. Results show that 4D-Var effectively reduces the error of ENSO analysis and therefore improves the prediction skill of ENSO events compared with the non-assimilation case. These results provide a promising way for the ICM to achieve better real-time ENSO prediction.
Nano-electro-mechanical pump: Giant pumping of water in carbon nanotubes
Authors: Farimani Amir Barati , Heiranian Mohammad , Aluru Narayana R. 
Published: May 2016

AbstractA fully controllable nano-electro-mechanical device that can pump fluids at nanoscale is proposed. Using molecular dynamics simulations, we show that an applied electric field to an ion@C60 inside a water-filled carbon nanotube can pump water with excellent efficiency. The key physical mechanism governing the fluid pumping is the conversion of electrical energy into hydrodynamic flow with efficiencies as high as 64%. Our results show that water can be compressed up to 7% higher than its bulk value by applying electric fields. High flux of water (up to 13,000 molecules/ns) is obtained by the electro-mechanical, piston-cylinder-like moving mechanism of the ion@C60 in the CNT. This large flux results from the piston-like mechanism, compressibility of water (increase in density of water due to molecular ordering), orienting dipole along the electric field and efficient electrical to mechanical energy conversion. Our findings can pave the way towards efficient energy conversion, pumping of fluids at nanoscale, and drug delivery.
Real-time functional magnetic resonance imaging neurofeedback in motor neurorehabilitation
Authors: Linden David E.J. , Turner Duncan L. 
Published: May 2016

Purpose of review
Recent developments in functional magnetic resonance imaging (fMRI) have catalyzed a new field of translational neuroscience. Using fMRI to monitor the aspects of task-related changes in neural activation or brain connectivity, investigators can offer feedback of simple or complex neural signals/patterns back to the participant on a quasireal-time basis [real-time-fMRI-based neurofeedback (rt-fMRI-NF)]. Here, we introduce some background methodology of the new developments in this field and give a perspective on how they may be used in neurorehabilitation in the future.

Recent findings
The development of rt-fMRI-NF has been used to promote self-regulation of activity in several brain regions and networks. In addition, and unlike other noninvasive techniques, rt-fMRI-NF can access specific subcortical regions and in principle any region that can be monitored using fMRI including the cerebellum, brainstem and spinal cord. In Parkinson's disease and stroke, rt-fMRI-NF has been demonstrated to alter neural activity after the self-regulation training was completed and to modify specific behaviours.

Summary
Future exploitation of rt-fMRI-NF could be used to induce neuroplasticity in brain networks that are involved in certain neurological conditions. However, currently, the use of rt-fMRI-NF in randomized, controlled clinical trials is in its infancy.