bluuebunny/crossref_metadata_2025_split huggingface dataset:
Total hip arthroplasty with subtrochanteric femoral shortening osteotomy using a monoblock cylindrical cementless stem for severe developmental hip dysplasia (Crowe type III, IV)
Authors: Kanda Akio , Obayashi Osamu , Mogami Atsuhiko , Morohashi Itaru , Ishijima Muneaki 
Published: September 2024

Background: Treatment of patients with Crowe type III and IV dislocated hips is challenging because of the hip deformity in these patients. In addition to the usual total hip replacement, shortening and reduction of the femur are often required. We herein report on our surgical technique using a monoblock cylindrical cementless stem and a direct lateral approach. Methods: This study included patients with a diagnosis of severe developmental dysplasia of the hip (Crowe types III and IV) who underwent primary total hip arthroplasty at our hospital from August 2019 to January 2022. Eleven hips of seven patients were treated. All patients underwent horizontal osteotomy using a monoblock cylindrical cementless stem and a direct lateral approach. Complications such as dislocation, infection, and implant dropout were evaluated. In addition, the clinical assessment included the hip range of motion at the last observation and hip function based on the Japanese Orthopaedic Association (JOA) hip score and the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ). Results: The average operation time was 224 min (range, 194–296 min), and the average bleeding amount was 396.1 g (range, 20–1010 g). The main complications were acetabular implant dislocation, postoperative dislocation, intraoperative arterial injury, intraoperative proximal femoral fracture, subsidence of femoral implant. and postoperative pulmonary infarction, which occurred in one patient each. Conclusion: Total hip arthroplasty for Crowe type III and IV hips is associated with various surgical technical difficulties because of its anatomical characteristics. While patients with severe osteoporosis are contraindicated, the use of a cylindrical monoblock cementless stem and the direct lateral approach makes it possible to simplify the procedure for shortening the femur and increase the indications for surgery. Level of evidence: Therapeutic Level Ⅳ.
Optically multiplexed neutron time-of-flight technique for inertial confinement fusion
Authors: Tafoya L. , Wilde C. , Cata B. , Freeman M. , Geppert-Kleinrath V. , Ivancic S. , Katz J. , McBride R. , Sorce A. , Stanley B. , Danly C. 
Published: September 2024

Neutron time-of-flight (nTOF) detectors are crucial in diagnosing the performance of inertial confinement fusion (ICF) experiments, which implode targets of deuterium–tritium fuel to achieve thermonuclear conditions. These detectors utilize the fusion neutron energy spectrum to extract key measurements, including the hotspot ion temperature and fuel areal density. Previous work [Danly et al., Rev. Sci. Instrum. 94, 043502 (2023)] has demonstrated adding 1D spatial resolution to an nTOF-like detector using a neutron aperture and streak camera to measure the ion temperature profile of an ICF implosion. By contrast, the study presented herein explores modifying the 1D detector to use a fast photomultiplier tube (PMT) to validate the design of a 2D spatially resolved instrument based on reconstruction from 1D profiles. The modification would collect time-of-flight traces from separate scintillators in an imaging array with one PMT using optical fibers of varying lengths to time-multiplex the signals. This technique has been demonstrated in ride-along experiments on the OMEGA laser with 20 fiber-coupled scintillator channels connected to a Photek PMT210. Results provide constraints on the fiber lengths and PMT gating requirements to promote pulse fidelity throughout all channels. Calibration of the detector to fixed nTOFs can provide a preliminary estimate of the instrument response function (IRF), although measurement of the IRF is currently under way. These results suggest that nTOF signals can potentially be time-multiplexed with fibers so long as the design is strategic to mitigate signal-to-noise reduction, modal dispersion, and charge build-up in the PMT, which has implications beyond ion temperature imaging.
Multi-wavelength optoelectronic synapse based on MoS2/WS2 van der waals heterostructures
Authors: Qiao Yadong , Wang Fadi , Guo Wei , Wang Yuhang , Wang Fengping 
Published: September 2024

Abstract
The utilization of two-dimensional van der waals heterostructures in optoelectronic synapses allows for the integration of information processing and memory, thereby providing novel operating platforms for simulating the perceptual visual systems and developing the neuromorphic computing systems due to its contactless, highly efficient and parallel computing. Herein, we have constructed a straightforward MoS2/WS2 heterostructure optoelectronic synapse and examined its capacity to imitate synaptic behaviors under optical stimulus. The MoS2/WS2 device demonstrated several synaptic functions, such as the excitatory postsynaptic current, short-term plasticity, long-term plasticity, pairs-pulse facilitation and ‘learning-experience’ behavior. Moreover, the MoS2/WS2 synaptic device can achieve a wide range of photo response wavelengths, spanning from UV to visible light, as well as the conversion from short-term plasticity to long-term plasticity. Furthermore, light-induced charge transfer due to adsorption and desorption of oxygen molecules in MoS2/WS2 heterostructure can be used to explain its working mechanism. Additionally, the synaptic plasticity of MoS2/WS2 device can be controlled by adjusting the duration, power and number of the optical pulses, which renders the MoS2/WS2-based optoelectronic synaptic device extremely favorable for implementation in the perceptual visual system.
Rich magnon topology in triangular lattice magnets
Authors: Yu Haodong , Hu Lin , Zheng Fawei , Yao Yugui 
Published: September 2024

Abstract
The two-dimensional magnet has been an emerging and rapidly growing field. The nontrivial topological phenomenon in these materials is an attracting subject. Yet, the realization of such magnets exhibiting topological magnons remains a challenge. Here, employing the linear spin-wave theory and the first-principles calculations, we propose that variety of topological phases exist in the triangular ferromagnet. These include magnon Chern insulators and high-order topological insulators. Interestingly, these topological states can coexist within a certain parameter space, leading to a hybrid topological state. We propose that these topological phases can be realized via atomic substitutions in

MnSe

2

or

MnTe

2

single-layers. The following detailed analysis suggests that non-uniform Dzyaloshinsky-Moriya interactions are crucial in achieving topological magnons. Our work unveil a unique approach to obtaining non-trivial topological magnons in two-dimensional materials.
Effect of textile pre-stretch and printed geometry on the curvature of PLA-Lycra 4D textiles
Authors: Pandini Stefano , Pasini Chiara , Battini Davide , Avanzini Andrea , Fiorentino Antonio , Bodini Ileana , Pasinetti Simone 
Published: September 2024

Abstract
4D textiles are a specific class of 4D printed materials obtained by printing flat patterns on elastically pre-tensioned textiles and being able to switch from planar systems to complex 3D objects after the textile pre-stretch is released. The mechanical balance between textile recovering strain and printed structure stiffness determines the final shape. This study is carried out by coupling pre-stretched Lycra to PLA and explores ways to control 4D textile shape transformations by varying pre-stretch (10% ÷ 60%), printed structure geometry (bar-shaped and star-shaped elements; star-shaped patterns), printed element thickness (0.3 ÷ 3 mm) and mutual distance (2 ÷ 15 mm). By adjusting these parameters, a wide set of out-of-plane curvatures are obtained, ranging from flat, to dome-like and highly curved, wrapped or coiled shapes. Digital optical methods, including digital image analysis, 3D scanning, and digital image correlation, are used to evaluate the complexity of the final shape and strain state evolution during shape transformation. The geometry variation is measured in terms of height increase (maximum 45 mm for a star-shaped system, 30 mm for a multiple star pattern) and of area decrease (maximum 80% for a star-shaped system, 60% for a multiple star pattern). While most shape transformations occur immediately after printing (‘direct 4D printing’), further shape evolutions may be triggered by heating above the PLA glass transition, allowing for the creation of dynamic structures whose shape changes upon external stimuli. The adhesion between the 3D printed element and the stretched textile is also examined, with a focus on determining the role of interfacial strength and the conditions that could enhance it. This study provides an overview of the primary design variables and valuable maps of their impacts on shape transformations in this broad scenario of influencing parameters.
Vector rogue waves in spin-1 Bose–Einstein condensates with spin–orbit coupling
Authors: He Jun-Tao , Li Hui-Jun , Lin Ji , Malomed Boris A 
Published: September 2024

Abstract
We analytically and numerically study three-component rogue waves (RWs) in spin-1 Bose–Einstein condensates with Raman-induced spin–orbit coupling (SOC). Using the multiscale perturbative method, we obtain approximate analytical solutions for RWs with positive and negative effective masses, determined by the effective dispersion of the system. The solutions include RWs with smooth and striped shapes, as well as higher-order RWs. The analytical solutions demonstrate that the RWs in the three components of the system exhibit different velocities and their maximum peaks appear at the same spatiotemporal position, which is caused by SOC and interactions. The accuracy of the approximate analytical solutions is corroborated by comparison with direct numerical simulations of the underlying system. Additionally, we systematically explore existence domains for the RWs determined by the baseband modulational instability (BMI). Numerical simulations corroborate that, under the action of BMI, plane waves with random initial perturbations excite RWs, as predicted by the approximate analytical solutions.
Quantum state classification via complex-valued neural networks
Authors: Dong Yu-Chao , Li Xi-Kun , Yang Ming , Lu Yan , Liao Yan-Lin , Ullah Arif , Lin Zhi 
Published: September 2024

Abstract
To efficiently complete quantum information processing tasks, quantum neural networks (QNNs) should be introduced rather than the common classical neural networks, but the QNNs in the current noisy intermediate-scale quantum era cannot perform better than classical neural networks because of scale and the efficiency limits. So if the quantum properties can be introduced into classical neural networks, more efficient classical neural networks may be constructed for tasks in the field of quantum information. Complex numbers play an indispensable role in the standard quantum theory, and constitute an important feature in quantum theory. So if complex numbers are introduced in classical neural networks, they may outperform the common classical neural networks in dealing with the tasks in the quantum information field. In this paper, we verify this conjecture by studying quantum state classification via complex-valued neural networks (CVNNs). The numerical results show that the performance of CVNNs is much better than the real-valued neural network in classifying the entangled states. Our results not only provide a new way to improve the performance of artificial neural networks in quantum state classifiers, but also might shed light on the study of CVNNs in the field of other quantum information processing tasks before the appearance of the universal quantum computer.
3-D parallel anisotropic inversion of controlled-source electromagnetic data using nested tetrahedral grids
Authors: Ren Zhengyong , Liu Zhengguang , Tang Jingtian 
Published: September 2024

SUMMARY
Geophysicists today face the challenge of quickly and reliably interpreting extensive controlled-source electromagnetic (CSEM) data sets to map subsurface conductivity structures within realistic geological environments. An ideal 3-D CSEM inversion algorithm using tetrahedral grids should be capable of distinguishing different resolution requirements between forward modelling and inversion grids, have an optimal parallel strategy that fully exploits the inherent independence of CSEM data sets while also possessing the capability to handle large-scale geo-electrical models, and incorporate conductivity anisotropy which should be a common characteristic in realistic subsurface environments. However, existing tools in the geo-electromagnetic community often fall short of these three demands. Addressing this gap, our study introduces a scalable and parallel anisotropic inversion technique for CSEM data, capitalizing on the potential of unstructured tetrahedral grids. We first apply the tetrahedral longest-edge bisection method to create a refined dense, heterogeneous forward modelling grid from a coarse inversion grid. This refinement, focused on areas around transmitters and receivers, is seamlessly integrated within the coarser inversion grid’s topology, enabling precise conductivity mapping and preserving electromagnetic response accuracy during model updates. We further innovate with a source-mesh double-level parallel strategy, utilizing the message passing interface technique for parallel handling of independent CSEM data sets and large-scale geo-electrical models. Externally, we dedicate a processor for inversion model updates employing the Limited-memory Broyden–Fletcher–Goldfarb–Shanno optimization algorithm and divide other processors into groups, each associated with specific transmitting sources and frequencies. Internally, in each group, we employ a domain-decomposition-based scalable and robust iterative solvers using the Auxiliary-Space Maxwell pre-conditioner to parallel quickly calculate the electromagnetic responses from its assigned source-frequency set. Additionally, recognizing the potential for electrical conductivity anisotropy in field data, we incorporate the case of vertical transverse isotropy. We validate the effectiveness of our method through examples, including an isotropic land model with undulating topography, an anisotropic marine model and a real-field data case. Results from both synthetic and field data inversions underscore our method’s significant advancements in efficiency and practicality, particularly in addressing large-scale 3-D CSEM data sets inversion challenges in realistic geological environments.
Resource shortage in public health facilities and private pharmacy practices in Odisha, India
Authors: Bose Bijetri , Cheng Terence C , Kalita Anuska , Haakenstaad Annie , Yip Winnie 
Published: September 2024

Abstract
In low- and-middle-income countries (LMICs), private pharmacies play a crucial role in the supply of medicines and the provision of healthcare. However, they also engage in poor practices including the improper sale of medicines and caregiving beyond their legal scope. Addressing the deficiencies of private pharmacies can increase their potential contribution towards enhancing universal health coverage. Therefore, it is important to identify the determinants of their performance. The existing literature has mostly focused on pharmacy-level factors and their regulatory environment, ignoring the market in which they operate, particularly their relationship to existing public sector provision. In this study, we fill the gap in the literature by examining the relationship between the practices of private pharmacies and resource shortages in nearby public health facilities in Odisha, India. This is possible due to three novel primary datasets with detailed information on private pharmacies and different levels of public healthcare facilities, including their geospatial coordinates. We find that when public healthcare facilities experience shortages of healthcare workers and essential medicines, private pharmacies step in to fill the gaps created by adjusting the type and amount of care provision and medicine dispensing services. Moreover, the relationship depends on their location, with public facilities and private pharmacies in rural areas performing substitutive caregiving roles, while they are complementary in urban areas. This study demonstrates how policies aimed at addressing resource shortages in public health facilities can generate dynamic responses from private pharmacies, highlighting the need for thorough scrutiny of the interaction between public healthcare facilities and private pharmacies in LMICs.
Multicentre evaluation of in vitro activity of contezolid against drug-resistant Staphylococcus and Enterococcus
Authors: Yang Wenhang , Li Xue , Chen Jiawei , Zhang Ge , Li Jin , Zhang Jingjia , Wang Tong , Kang Wei , Gao Haotian , Zhang Zhijie , Liu Yong , Xiao Yuling , Xie Yi , Zhao Jianhong , Mao Liyan , Sun Ziyong , Li Gang , Jia Wei , Song Guibo , Shan Bin , Yu Yanhua , Sun Guizhen , Xu Yingchun , Liu Yali 
Published: September 2024

Abstract

Background
To investigate susceptibility to contezolid, a novel oxazolidinone, multicentre surveillance was conducted involving 2449 strains of Staphylococcus and Enterococcus collected from 65 hospitals across China.

Methods
The MICs of contezolid, linezolid and other clinically significant antibiotics were determined by the broth microdilution method. Consistency with the broth microdilution method for contezolid was assessed using agar dilution method, as well as disc diffusion and ETEST for linezolid, respectively. WGS was conducted on all 20 linezolid-resistant and 30 randomly non-resistant strains to analyse linezolid resistance genes (optrA, poxtA, cfr) and 23S rRNA mutation sites.

Results
All strains exhibited WT susceptibility to contezolid, while resistance proportions to daptomycin, vancomycin, teicoplanin, tigecycline and eravacycline ranged from 0% to 5.2% in Staphylococcus, and from 0% to 7.8% in Enterococcus. Linezolid resistance was higher in Enterococcus faecalis (4.4%) compared with Enterococcus faecium (0.2%). Contezolid showed a lower MIC50 (0.5 mg/L) than linezolid (2 mg/L) for methicillin-resistant Staphylococcus. Against Enterococcus, contezolid demonstrated a cumulative MIC percentage of 70% for VRE and 39.1% for E. faecalis (at MIC = 1 mg/L), whereas linezolid showed 0% and 1.1%, respectively. Among the 20 linezolid-resistant Enterococcus strains, all carried the optrA gene without 23S rRNA mutations. For contezolid, MICs were 4 mg/L for 19 strains and 2 mg/L for 1 strain. The ETEST, agar dilution and disc diffusion methods showed essential and categorical agreements of &gt;90% for linezolid, with no major errors or very major errors.

Conclusions
Contezolid demonstrated significant in vitro antibacterial activity against methicillin-resistant Staphylococcus, VRE and linezolid-resistant E. faecalis.
Salvage radiotherapy for locoregional recurrence of esophageal cancer after surgery
Authors: Torii Akira , Tomita Natsuo , Takaoka Taiki , Kondo Takuhito , Yamamoto Shintaro , Sugie Chikao , Nagai Aiko , Miyakawa Akifumi , Kuno Mayu , Uchiyama Kaoru , Otsuka Shinya , Ogawa Yasutaka , Takano Seiya , Kita Nozomi , Tanaka Tatsuya , Ogawa Ryo , Kubota Eiji , Takiguchi Shuji , Kataoka Hiromi , Hiwatashi Akio 
Published: September 2024

Abstract

Objective
There is no consensus on the optimal treatment for patients with locoregional recurrence of esophageal cancer after surgery. The objective of this study was to investigate the outcomes and prognostic factors associated with salvage radiotherapy in patients with locoregional recurrence of esophageal cancer after surgery.

Methods
We reviewed 80 patients with locoregional recurrence of esophageal cancer after surgery who were treated with radiotherapy. The median dose was 60 Gy, and 29 patients (36%) received elective nodal irradiation. Fifty-three patients (66%) received concurrent chemotherapy (mostly 5-fluorouracil and cisplatin) during radiotherapy. Overall survival, progression-free survival and in-field recurrence rate were assessed.

Results
The median follow-up period was 17 months. Two-year overall survival, progression-free survival and in-field recurrence rate were 50.3%, 23.5% and 41.3%, respectively. On multivariate analysis, a maximum diameter of locoregional recurrence lesions &lt;30 mm was associated with higher overall survival (P = 0.044). Disease-free interval between surgery and locoregional recurrence &gt;14 months was associated with higher PFS (P = 0.003). Late grade 3 toxicities occurred in three patients (3.8%). No grade 4 or higher toxicity was observed.

Conclusions
Salvage radiotherapy demonstrated efficacy in achieving in-field control with acceptable toxicity. However, the high rate of out-of-field metastases led to poor progression-free survival and overall survival, particularly in cases involving large lesions and a short disease-free interval. A prospective study is warranted to establish a treatment strategy, particularly considering the combined use of effective anti-cancer drugs.
CRISPR/Cas9-mediated multiplex gene editing of gamma and omega gliadins: paving the way for gliadin-free wheat
Authors: Sánchez-León Susana , Marín-Sanz Miriam , Guzmán-López María H , Gavilán-Camacho Marta , Simón Edurne , Barro Francisco 
Published: September 2024

Abstract
Wheat is a staple cereal in the human diet. Despite its significance, an increasing percentage of the population suffers adverse reactions to wheat, which are triggered by wheat gluten, particularly the gliadin fractions. In this study, we employed CRISPR/Cas [clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein] multiplexing to introduce targeted mutations into γ- and ω-gliadin genes of wheat, to produce lines deficient in one or both immunogenic gliadin fractions simultaneously. For this study, eight single guide RNAs (sgRNAs) were designed and combined into four plasmids to produce 59 modified wheat lines, of which 20 exhibited mutations in the target genes. Characterization of these lines through Sanger sequencing or next-generation sequencing revealed a complex pattern of InDels, including deletions spanning multiple sgRNAs. The mutations were transmitted to the offspring, and the analysis of homozygous derived lines by reverse-phase HPLC and monoclonal antibodies showed a 97.7% reduction in gluten content. Crossing these lines with other CRISPR/Cas lines deficient in the α-gliadins allowed multiple mutations to be combined. This work represents an important step forward in the use of CRISPR/Cas to develop gluten-free wheat.