bluuebunny/crossref_metadata_2025_split huggingface dataset:
“The Buoy”: Utilization of a low-threshold ambulatory setting for traumatized children and adolescents in Austria
Authors: Huemer J. , Völkl-Kernstock S. , Yee A. , Bruckner T. , Skala Katrin 
Published: March 2016

Summary

Background
This investigation intended to assess the use of an outpatient clinic providing low-threshold, short-term trauma therapy for children and adolescents across the first 6 years of its existence.

Methods
A retrospective analysis of the records of all patients undergoing treatment in this institution between 2001 and 2007 (n = 2510) has been performed. We evaluated demographic data, reason for contacting the unit, the referring person or institution, the person or institution in charge of the care and custody of the child, the number of contacts with the clinic, presence of physical or psychiatric illness of a parent, and medications prescribed.

Results
Ages of patients ranged from 1 to 17. Gender distribution was even. Having experienced the death of a relative, experienced violence, or having witnessed traumatic death were the main reasons for presentation. The utilization rates of immigrants rose throughout the observation period. Children from foster care were seen less frequently than expected. Medication was hardly prescribed.

Conclusions
Ample utilization of this institution clearly demonstrates the need for short-term acute outpatient trauma therapy for children and adolescents. Efforts to provide easily accessible institutions for youth who experience traumatic events should be stepped up.
Intra‐axonal protein synthesis in development and beyond
Authors: Batista Andreia Filipa Rodrigues , Hengst Ulrich 
Published: March 2016

AbstractProteins can be locally produced in the periphery of a cell, allowing a rapid and spatially precise response to the changes in its environment. This process is especially relevant in highly polarized and morphologically complex cells such as neurons. The study of local translation in axons has evolved from being primarily focused on developing axons, to the notion that also mature axons can produce proteins. Axonal translation has been implied in several physiological and pathological conditions, and in all cases it shares common molecular actors and pathways as well as regulatory mechanisms. Here, we review the main findings in these fields, and attempt to highlight shared principles.
Functional Magnetic Stimulation of Inspiratory and Expiratory Muscles in Subjects With Tetraplegia
Authors: Zhang Xiaoming , Plow Ela , Ranganthan Vinoth , Huang Honglian , Schmitt Melissa , Nemunaitis Gregory , Kelly Clay , Frost Frederick , Lin Vernon 
Published: March 2016

AbstractBackgroundRespiratory complications are major causes of morbidity and mortality in persons with a spinal cord injury, partly because of respiratory muscle paralysis. Earlier investigation has demonstrated that functional magnetic stimulation (FMS) can be used as a noninvasive technology for activating expiratory muscles, thus producing useful expiratory functions (simulated cough) in subjects with spinal cord injury.ObjectiveTo evaluate the effectiveness of FMS for conditioning inspiratory and expiratory muscles in persons with tetraplegia.DesignA prospective before and after trial.SettingFMS Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH.ParticipantsSix persons with tetraplegia.MethodEach subject participated in a 6‐week FMS protocol for conditioning the inspiratory and expiratory muscles. A magnetic stimulator was used with the center of a magnetic coil placed at the C7‐T1 and T9‐T10 spinous processes, respectively. Pulmonary function tests were performed before, during, and after the protocol.Main Outcome MeasurementsRespiratory variables included maximal inspiratory pressure (MIP), inspiratory reserve volume (IRV), peak inspiratory flow (PIF), maximal expiratory pressure (MEP), expiratory reserve volume (ERV), and peak expiratory flow (PEF).ResultsAfter 6 weeks of conditioning, the main outcome measurements (mean ± standard error) were as follows: MIP, 89.6 ± 7.3 cm H2O; IRV, 1.90 ± 0.34 L; PIF, 302.4 ± 36.3 L/min; MEP, 67.4 ± 11.1 cm H2O; ERV, 0.40 ± 0.06 L; and PEF, 372.4 ± 31.9 L/min. These values corresponded to 117%, 107%, 136%, 109%, 130%, and 124% of pre‐FMS conditioning values, respectively. Significant improvements were observed in MIP (P = .022), PIF (P = .0001), and PEF (P = .0006), respectively. When FMS was discontinued for 4 weeks, these values showed decreases from their values at the end of the conditioning protocol, which suggests that continual FMS may be necessary to maintain improved respiratory functions.ConclusionFMS conditioning of the inspiratory and expiratory muscles improved voluntary inspiratory and expiratory functions. FMS may be a noninvasive technology for respiratory muscle training in persons with tetraplegia.
WADGE HIERARCHY OF DIFFERENCES OF CO-ANALYTIC SETS
Authors: FOURNIER KEVIN 
Published: March 2016

AbstractWe begin the fine analysis of nonBorel pointclasses. Working in ZFC + DET$\left( {_1^1 } \right)$, we describe the Wadge hierarchy of the class of increasing differences of co-analytic subsets of the Baire space by extending results obtained by Louveau ([5]) for the Borel sets.
INITIAL SEGMENTS OF THE ENUMERATION DEGREES
Authors: GANCHEV HRISTO , SORBI ANDREA 
Published: March 2016

AbstractUsing properties of${\cal K}$-pairs of sets, we show that every nonzero enumeration degreeabounds a nontrivial initial segment of enumeration degrees whose nonzero elements have all the same jump asa. Some consequences of this fact are derived, that hold in the local structure of the enumeration degrees, including: There is an initial segment of enumeration degrees, whose nonzero elements are all high; there is a nonsplitting high enumeration degree; every noncappable enumeration degree is high; every nonzero low enumeration degree can be capped by degrees of any possible local jump (i.e., any jump that can be realized by enumeration degrees of the local structure); every enumeration degree that bounds a nonzero element of strictly smaller jump, is bounding; every low enumeration degree below a non low enumeration degreeacan be capped belowa.
SMOOTHNESS OF BOUNDED INVARIANT EQUIVALENCE RELATIONS
Authors: KRUPIŃSKI KRZYSZTOF , RZEPECKI TOMASZ 
Published: March 2016

AbstractWe generalise the main theorems from the paper “The Borel cardinality of Lascar strong types” by I. Kaplan, B. Miller and P. Simon to a wider class of bounded invariant equivalence relations. We apply them to describe relationships between fundamental properties of bounded invariant equivalence relations (such as smoothness or type-definability) which also requires finding a series of counterexamples. Finally, we apply the generalisation mentioned above to prove a conjecture from a paper by the first author and J. Gismatullin, showing that the key technical assumption of the main theorem (concerning connected components in definable group extensions) from that paper is not only sufficient but also necessary to obtain the conclusion.
Deficit in rewarding mechanisms and prefrontal left/right cortical effect in vulnerability for internet addiction
Authors: Balconi Michela , Finocchiaro Roberta 
Published: March 2016

ObjectiveThe present research explored the cortical correlates of rewarding mechanisms and cortical ‘unbalance’ effect in internet addiction (IA) vulnerability.MethodsInternet Addiction Inventory (IAT) and personality trait (Behavioural Inhibition System, BIS; Behavioural Activation System, BAS) were applied to 28 subjects. Electroencephalographic (EEG, alpha frequency band) and response times (RTs) were registered during a Go-NoGo task execution in response to different online stimuli: gambling videos, videogames or neutral stimuli. Higher-IAT (more than 50 score, with moderate or severe internet addiction) and lower-IAT (<50 score, with no internet addiction).ResultsAlpha band and RTs were affected by IAT, with significant bias (reduced RTs) for high-IAT in response to gambling videos and videogames; and by BAS, BAS-Reward subscale (BAS-R), since not only higher-IAT, but also BAS and BAS-R values determined an increasing of left prefrontal cortex (PFC) activity (alpha reduction) in response to videogames and gambling stimuli for both Go and NoGo conditions, in addition to decreased RTs for these stimuli categories.ConclusionThe increased PFC responsiveness and the lateralisation (left PFC hemisphere) effect in NoGo condition was explained on the basis of a ‘rewarding bias’ towards more rewarding cues and a deficit in inhibitory control in higher-IAT and higher-BAS subjects. In contrast lower-IAT and lower-BAS predicted a decreased PFC response and increased RTs for NoGo (inhibitory mechanism). These results may support the significance of personality (BAS) and IAT measures for explaining future internet addiction behaviour based on this observed ‘vulnerability’.
New Radiocarbon Dates and Bayesian Models for Nelson Bay Cave and Byneskranskop 1: Implications for the South African Later Stone Age Sequence
Authors: Loftus Emma , Sealy Judith , Lee-Thorp Julia 
Published: March 2016

AbstractThe southern African Later Stone Age sequence is widely considered to be well dated based on radiocarbon dates from dozens of archaeological sites, and apparently shows more or less synchronous cultural shifts across an extensive area. Yet, closer examination reveals the inadequacy of many of the decades-old and uncalibrated individual site chronologies that underpin this regional chronology, making robust comparisons of the chronology of technological change across this region impossible. Here, we present 26 new AMS14C dates and Bayesian modeled chronologies for two important archaeological cave sites in southernmost Africa, Nelson Bay Cave and Byneskranskop 1. The results provide more robust age estimates for these cultural and paleoenvironmental sequences and revise interpretations of these sites in several instances. This project demonstrates the necessity of redating key sites, and the value of currently underutilized methods, including calibration and Bayesian modeling, for southern African archaeology.
Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence
Authors: Dou Ruoxu , Ng Kimmie , Giovannucci Edward L. , Manson JoAnn E. , Qian Zhi Rong , Ogino Shuji 
Published: March 2016

AbstractIn many cells throughout the body, vitamin D is converted into its active form calcitriol and binds to the vitamin D receptor (VDR), which functions as a transcription factor to regulate various biological processes including cellular differentiation and immune response. Vitamin D-metabolising enzymes (including CYP24A1 and CYP27B1) and VDR play major roles in exerting and regulating the effects of vitamin D. Preclinical and epidemiological studies have provided evidence for anti-cancer effects of vitamin D (particularly against colorectal cancer), although clinical trials have yet to prove its benefit. In addition, molecular pathological epidemiology research can provide insights into the interaction of vitamin D with tumour molecular and immunity status. Other future research directions include genome-wide research on VDR transcriptional targets, gene–environment interaction analyses and clinical trials on vitamin D efficacy in colorectal cancer patients. In this study, we review the literature on vitamin D and colorectal cancer from both mechanistic and population studies and discuss the links and controversies within and between the two parts of evidence.
IMPLEMENTATION OF HEALTH TECHNOLOGY ASSESSMENT WORK IN A HOSPITAL IN KAZAKHSTAN
Authors: Kosherbayeva Lyazzat , Hailey David , Kurakbaev Kural , Tsoy Aleksey , Zhuzzhanov Ormanbek , Donbay Abilay , Kumar Ainur , Nadyrov Kamalzhan 
Published: March 2016

Objectives: The aim of this study was to implement health technology assessment (HA) in the First General City Hospital in Astana, Kazakhstan.Methods: We organized trainings to familiarize hospital staff with the purpose and details of HTA. An HTA committee was established, with representation from hospital physicians and managers, and criteria for prioritization of health technologies determined. Clinical departments of the hospital were asked to prepare applications for new technologies for their services.Results: The HTA committee reviewed five applications and selected a technology from one of these, on single incision laparoscopic surgery (SILS), for assessment. A short HTA report on SILS was prepared, covering its safety, clinical effectiveness, and cost effectiveness. The report was used to support a request to the Department of Health for additional funding to implement this technology within the hospital. This funding was approved and SILS was established in several hospital departments.Conclusions: This successful initial experience with HTA has paved the way for its routine use by the hospital for informing decisions on the procurement and use of new health technologies.
Undignified Arguments
Authors: HOLM SØREN 
Published: March 2016

Abstract:Something strange has happened to the concept of dignity in bioethics. After a long period in which U.S. pragmatist and U.K. consequentialist philosophers have argued that the concept is useless and vacuous, and in which they have been reasonably successful in expunging it from mainstream English-language academic bioethics, dignity has suddenly become popular again in debates about the legalization of physician-assisted dying (PAD). And, even stranger, it is deployed not by conservatives but by liberals. In the debates about PAD, liberal proponents of legalization seem to accept without question that there is such a state or process as “death with dignity,” which is juxtaposed to “undignified dying.” It also seems to be accepted that both of these states can be fairly easily identified and that they carry great moral weight. This article provides an analysis of the current resurgence of “undignified” arguments and argues on the basis of that analysis (1) that a proper understanding of the concept of dignity shows that the previous reductive arguments against dignity are partially incomplete and therefore partially misguided and (2) that, despite dignity having meaning, the idea of an undignified death cannot carry the moral weight it is given by proponents of the legalization of PAD.
Natural Good Theories and the Value of Human Dignity
Authors: MUDERS SEBASTIAN 
Published: March 2016

Abstract:One of the widely recognized facts about human dignity is its vastly divergent applicability—from highly controversial issues in bioethics to broader topics in political philosophy. A group of theories that this article subsumes under the header “natural good theories” appears to be especially fitted for normatively multifaceted notions like dignity. However, the heavy normative weight the concept of dignity has to bear due to the central position it occupies within these theories creates its own difficulties. As is shown in a discussion of Martha Nussbaum’s capability conception of dignity, dignity appears to be unable to mirror the special normative relevance people want to assign to it in cases of great moral misconduct. The article provides a suggestion on how to solve this problem by means of paradigmatic cases that work as material constraints regarding the exact boundaries of dignity violations.
Artificial Intelligence
Authors: LAWRENCE DAVID R. , PALACIOS-GONZÁLEZ CÉSAR , HARRIS JOHN 
Published: March 2016

Abstract:It seems natural to think that the same prudential and ethical reasons for mutual respect and tolerance that one has vis-à-vis other human persons would hold toward newly encountered paradigmatic but nonhuman biological persons. One also tends to think that they would have similar reasons for treating we humans as creatures that count morally in our own right. This line of thought transcends biological boundaries—namely, with regard to artificially (super)intelligent persons—but is this a safe assumption? The issue concerns ultimate moral significance: the significance possessed by human persons, persons from other planets, and hypothetical nonorganic persons in the form of artificial intelligence (AI). This article investigates why our possible relations to AI persons could be more complicated than they first might appear, given that they might possess a radically different nature to us, to the point that civilized or peaceful coexistence in a determinate geographical space could be impossible to achieve.
Using a Scoring Rubric to Assess the Writing of Bioethics Students
Authors: STODDARD HUGH A. , LABRECQUE CORY A. , SCHONFELD TOBY 
Published: March 2016

Abstract:Educators in bioethics have struggled to find valid and reliable assessments that transcend the “reproduction of knowledge” to target more important skill sets. This manuscript reports on the process of developing and grading a minimal-competence comprehensive examination in a bioethics master’s degree program. We describe educational theory and practice for the creation and deployment of scoring rubrics for high-stakes performance assessments that reduce scoring inconsistencies. The rubric development process can also benefit the program by building consensus among stakeholders regarding program goals and student outcomes.We describe the Structure of the Observed Learning Outcome taxonomy as a mechanism for rubric design and provide an example of how we applied that taxonomy to define pass/fail cut scores. Details about domains of assessment and writing descriptors of performance are also presented. Despite the laborious work required to create a scoring rubric, we found the effort to be worthwhile for our program.
How Should Health Data Be Used?
Authors: KAPLAN BONNIE 
Published: March 2016

Abstract:Electronic health records, data sharing, big data, data mining, and secondary use are enabling exciting opportunities for improving health and healthcare while also exacerbating privacy concerns. Two court cases about selling prescription data, the Sorrell case in the U.S. and the Source case in the U.K., raise questions of what constitutes “privacy” and “public interest”; they present an opportunity for ethical analysis of data privacy, commodifying data for sale and ownership, combining public and private data, data for research, and transparency and consent. These interwoven issues involve discussion of big data benefits and harms and touch on common dualities of the individual versus the aggregate or the public interest, research (or, more broadly, innovation) versus privacy, individual versus institutional power, identification versus identity and authentication, and virtual versus real individuals and contextualized information. Transparency, flexibility, and accountability are needed for assessing appropriate, judicious, and ethical data uses and users, as some are more compatible with societal norms and values than others.
Reading a book in one or two languages? An eye movement study of cognate facilitation in L1 and L2 reading
Authors: COP USCHI , DIRIX NICOLAS , VAN ASSCHE EVA , DRIEGHE DENIS , DUYCK WOUTER 
Published: March 2016

This study examined how noun reading by bilinguals is influenced by orthographic similarity with their translation equivalents in another language. Eye movements of Dutch–English bilinguals reading an entire novel in L1 and L2 were analyzed.In L2, we found a facilitatory effect of orthographic overlap. Additional facilitation for identical cognates was found for later eye movement measures. This shows that the complex, semantic context of a novel does not eliminate cross-lingual activation in natural reading.In L1 we detected non-identical cognate facilitation for first fixation durations of longer nouns. Identical cognate facilitation was found on total reading times for high frequent nouns. This study is the first to show cognate facilitation in L1 reading of narrative text. This shows that even when reading a novel in the mother tongue, lexical access is not restricted to the target language.
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank
Authors: Lane Jacqueline M. , Vlasac Irma , Anderson Simon G. , Kyle Simon D. , Dixon William G. , Bechtold David A. , Gill Shubhroz , Little Max A. , Luik Annemarie , Loudon Andrew , Emsley Richard , Scheer Frank A. J. L. , Lawlor Deborah A. , Redline Susan , Ray David W. , Rutter Martin K. , Saxena Richa 
Published: March 2016

AbstractOur sleep timing preference, or chronotype, is a manifestation of our internal biological clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical performance, and chronic disease. Here we perform a genome-wide association study of self-reported chronotype within the UK Biobank cohort (n=100,420). We identify 12 new genetic loci that implicate known components of the circadian clock machinery and point to previously unstudied genetic variants and candidate genes that might modulate core circadian rhythms or light-sensing pathways. Pathway analyses highlight central nervous and ocular systems and fear-response-related processes. Genetic correlation analysis suggests chronotype shares underlying genetic pathways with schizophrenia, educational attainment and possibly BMI. Further, Mendelian randomization suggests that evening chronotype relates to higher educational attainment. These results not only expand our knowledge of the circadian system in humans but also expose the influence of circadian characteristics over human health and life-history variables such as educational attainment.
Disorder-mediated crowd control in an active matter system
Authors: Pinçe Erçağ , Velu Sabareesh K. P. , Callegari Agnese , Elahi Parviz , Gigan Sylvain , Volpe Giovanni , Volpe Giorgio 
Published: March 2016

AbstractLiving active matter systems such as bacterial colonies, schools of fish and human crowds, display a wealth of emerging collective and dynamic behaviours as a result of far-from-equilibrium interactions. The dynamics of these systems are better understood and controlled considering their interaction with the environment, which for realistic systems is often highly heterogeneous and disordered. Here, we demonstrate that the presence of spatial disorder can alter the long-term dynamics in a colloidal active matter system, making it switch between gathering and dispersal of individuals. At equilibrium, colloidal particles always gather at the bottom of any attractive potential; however, under non-equilibrium driving forces in a bacterial bath, the colloids disperse if disorder is added to the potential. The depth of the local roughness in the environment regulates the transition between gathering and dispersal of individuals in the active matter system, thus inspiring novel routes for controlling emerging behaviours far from equilibrium.
Nitrogen cycling in an extreme hyperarid environment inferred from δ15N analyses of plants, soils and herbivore diet
Authors: Díaz Francisca P. , Frugone Matías , Gutiérrez Rodrigo A. , Latorre Claudio 
Published: March 2016

AbstractClimate controls on the nitrogen cycle are suggested by the negative correlation between precipitation and δ15N values across different ecosystems. For arid ecosystems this is unclear, as water limitation among other factors can confound this relationship. We measured herbivore feces, foliar and soil δ15N and δ13C values and chemically characterized soils (pH and elemental composition) along an elevational/climatic gradient in the Atacama Desert, northern Chile. Although very positive δ15N values span the entire gradient, soil δ15N values show a positive correlation with aridity as expected. In contrast, foliar δ15N values and herbivore feces show a hump-shaped relationship with elevation, suggesting that plants are using a different N source, possibly of biotic origin. Thus at the extreme limits of plant life, biotic interactions may be just as important as abiotic processes, such as climate in explaining ecosystem δ15N values.