bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming low yields of plant‐made antibodies by a protein engineering approach
Authors: Zischewski Julia , Sack Markus , Fischer Rainer 
Published: December 2015

AbstractThe commercial development of plant‐based antibody production platforms is often limited by low and variable yields, but little is known about the factors that affect antibody accumulation during and after translation. Here, we present a strategy to identify yield‐limiting regions in the transcript and protein. We exchanged variable heavy chain (VH) domain sequences between two human antibodies at structurally conserved positions, thus creating ten chimeric VH domains containing sequences from M12 (∼1000 μg/g leaf fresh weight [FW]) and 4E10 (∼100 μg/g FW). After transient expression in Nicotiana benthamiana leaves, we measured mRNA and protein levels by quantitative real‐time PCR and surface plasmon resonance spectroscopy, respectively. Transcript levels were similar for all constructs, but antibody levels ranged from ∼250 μg/g to over 2000 μg/g FW. Analysis of the expression levels showed that: i) 4E10 yields were only marginally increased by suppression of post‐transcriptional gene silencing; ii) the CDR3 of 4E10 contains a protease site; and iii) a bipartite, yield‐limiting region exists in the CDR2/CDR3. Our findings highlight the strong impact of cotranslational and posttranslational events on antibody yields and show that protein engineering is a powerful tool that can be used to overcome the remaining limitations affecting antibody production in plants.
Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins
Authors: Arfi Zulfaquar Ahmad , Hellwig Stephan , Drossard Jürgen , Fischer Rainer , Buyel Johannes Felix 
Published: December 2015

AbstractThe production of biopharmaceutical proteins in plants requires efficient downstream processing steps that remove impurities such as host cell proteins (HCPs) and adventitious endotoxins produced by bacteria during transient expression. We therefore strived to develop effective routines for endotoxin removal from plant extracts and the subsequent use of the extracts to generate antibodies detecting a broad set of HCPs. At first, we depleted the superabundant protein ribulose‐1,5‐bisphosphate carboxylase/oxygenase (RuBisCO) for which PEG precipitation achieved the best results, preventing a dominant immune reaction against this protein. We found that a mixture of sera from rabbits immunized with pre‐depleted or post‐depleted extracts detected more HCPs than the individual sera used alone. We also developed a powerful endotoxin removal procedure using Polymyxin B for extracts from wild type plants or a combination of fiber‐flow filtration and EndoTrap Blue for tobacco plants infiltrated with Agrobacterium tumefaciens. The antibodies we generated will be useful for quality and performance assessment in future process development and the methods we present can easily be transferred to other expression systems rendering them useful in the field of plant molecular farming.
Five‐year analysis from phase 2 trial of “sandwich” chemoradiotherapy in newly diagnosed, stage IE to IIE, nasal type, extranodal natural killer/T‐cell lymphoma
Authors: Zhang Li , Jiang Ming , Xie Li , Zhang Hong , Jiang Yu , Yang Qun‐pei , Liu Wei‐ping , Zhang Wen‐yan , Zhuo Hong‐yu , Li Ping , Chen Nian‐yong , Zhao Sha , Wang Feng , Zou Li‐qun 
Published: December 2015

AbstractThe “sandwich” protocol, was first proposed by us and comprised of l‐asparaginase, vincristine, and prednisone chemotherapy with radiotherapy, results in 2‐year overall survival and progression‐free survival rates that surpass traditional therapies for patients with newly diagnosed, stage IE‐IIE, nasal type, extranodal natural killer/T‐cell lymphoma. The results had been published by cancer. These patients were followed up over a median period of 67 months, for which updates and the results of prognostic factors analyses are presented. The 5‐year overall survival and progress‐free survival rates were both 64%. The highest rates of death occurred during the first 6 months, and between the second and third year after enrollment. The initial therapeutic response (odds ratio = 5.83; P = 0.001) and B symptoms (odds ratio = 6.13; P = 0.043) were significant prognostic factors for overall survival. However, the international prognostic index was not significant for progress‐free survival and overall survival. There were no severe long‐term side effects. These results indicate that the “sandwich” protocol may benefit the long‐term survival of patients with newly diagnosed stage IE‐IIE, nasal type, extranodal natural killer/T‐cell lymphoma. However, additional studies with larger samples are required to confirm these results. This study is registered at www.Chictr.org (ChicTR‐TNC‐09000394).
Intermetallic Compounds as Selective Heterogeneous Catalysts: Insights from DFT
Authors: Krajčí Marian , Hafner Jürgen 
Published: December 2015

AbstractDuring the last decade, it has been demonstrated that the use of intermetallic compounds composed of simple and transition metals as catalysts leads to improved activity and selectivity for a number of industrially important processes. Herein, we discuss the insight gained from density functional theory (DFT) calculations for the example of the semihydrogenation of acetylene to ethylene catalyzed by compounds of Pd with Ga or Al and of Co or Fe with Al. Investigations of the potentially active surfaces demonstrate that the chemical composition of nonstoichiometric surfaces depends strongly on the preparation conditions. Ga‐ or Al‐terminated surfaces are catalytically inactive because they cannot dissociate hydrogen, but Pd‐terminated surfaces are also unfavorable because the activation energy for the rate‐controlling step is higher than the desorption energy of acetylene. Active sites promoting a selective semihydrogenation are triangular groups consisting of two simple‐metal (Al, Ga) atoms and one transition‐metal (Pd, Co) atom. Acetylene is strongly bound to simple‐metal atoms in a di‐σ configuration, whereas ethylene is weakly π bonded on top of a transition‐metal atom. The change from strong to weak bonding is of great importance for the selectivity of the process. The novel point elucidated by the DFT calculations is the strong reactivity of the non‐transition‐metal atoms arising from the strong metallocovalent bonding in the compounds, which also contributes to their stability.
Ruthenium Dispersion: A Key Parameter for the Stability of Supported Ruthenium Catalysts during Catalytic Supercritical Water Gasification
Authors: Peng Gaël , Ludwig Christian , Vogel Frédéric 
Published: December 2015

AbstractThe catalytic supercritical water gasification of isopropanol (450 °C, 30 MPa) over Ru catalysts supported on carbon and metal oxides was performed in a fixed‐bed plug flow reactor. The Ru loading was between 1.2 and 2 %. The catalyst stability over a period of 50 h was in the order: Ru/C>Ru/ZrO2>Ru/Al2O3≈Ru/TiO2. Considerable coke deposits were found on Ru/Al2O3 and Ru/TiO2, which suggests that coke formation was responsible for the loss of activity, whereas the coke content was much lower on Ru/C and Ru/ZrO2, which confirms their better coking resistance. Clearly, Ru/C was the most stable catalyst as a loss of only 3 % of its initial activity was measured. The high Ru dispersion of Ru/C and Ru/ZrO2 was beneficial for the improvement of the catalyst stability because of the higher gasification rate versus the coke formation rate.
Polarized Neutron Diffraction as a Tool for Mapping Molecular Magnetic Anisotropy: Local Susceptibility Tensors in CoII Complexes
Authors: Ridier Karl , Gillon Béatrice , Gukasov Arsen , Chaboussant Grégory , Cousson Alain , Luneau Dominique , Borta Ana , Jacquot Jean‐François , Checa Ruben , Chiba Yukako , Sakiyama Hiroshi , Mikuriya Masahiro 
Published: December 2015

AbstractPolarized neutron diffraction (PND) experiments were carried out at low temperature to characterize with high precision the local magnetic anisotropy in two paramagnetic high‐spin cobalt(II) complexes, namely [CoII(dmf)6](BPh4)2 (1) and [CoII2(sym‐hmp)2](BPh4)2 (2), in which dmf=N,N‐dimethylformamide; sym‐hmp=2,6‐bis[(2‐hydroxyethyl)methylaminomethyl]‐4‐methylphenolate, and BPh4−=tetraphenylborate. This allowed a unique and direct determination of the local magnetic susceptibility tensor on each individual CoII site. In compound 1, this approach reveals the correlation between the single‐ion easy magnetization direction and a trigonal elongation axis of the CoII coordination octahedron. In exchange‐coupled dimer 2, the determination of the individual CoII magnetic susceptibility tensors provides a clear outlook of how the local magnetic properties on both CoII sites deviate from the single‐ion behavior because of antiferromagnetic exchange coupling.
Protein Adsorption Switch Constructed by a Pillar[5]arene‐Based Host–Guest Interaction
Authors: Xiao Xuan , Nie Guanrong , Zhang Xiaoyan , Tian Demei , Li Haibing 
Published: December 2015

AbstractThe interfacial properties of solid substrates are of importance for protein adsorption. Herein, we report a reversible protein adsorption switch based on the host–guest interaction of the butoxy pillar[5]arene and adipic acid. By the detector of the contact angle (CA), atomic force microscopy (AFM), and luminoscope on the silicon substrate, the intelligent protein switch exhibits excellent adsorptivity for BSA and switch performance by pH regulation.
ChemInform Abstract: Cubic Structure of the Mixed Halide Perovskite CH3NH3PbI3‐xClx via Thermal Annealing.
Authors: Luo Deying , Yu Leiming , Wang Hai , Zou Taoyu , Luo Li , Liu Zhu , Lu Zhenghong 
Published: December 2015

AbstractCubic MeNH3PbI3‐xClx films of 530 nm thickness and a large crystalline structure are obtained by vacuum deposition using MeNH3I and PbCl2 in the molar ratio of 3:1 as precursors in alumina crucibles, followed by thermal treatment at 70‐120 °C for 1 h.
ChemInform Abstract: Quaternary Rare‐Earth Arsenides REAg1‐xZnyAs2 (RE: La—Nd, Sm, Gd—Dy) with Tetragonal SrZnBi2‐ and HfCuSi2‐Type Structures.
Authors: Ramachandran Krishna K. , Genet Clement , Mar Arthur 
Published: December 2015

AbstractThe title compounds are prepared from stoichiometric mixtures of the elements (silica tubes, 800 °C, 20 d) and characterized by powder and single crystal XRD, magnetic measurements, and TB‐LMTO‐ASA band structure calculations.
ChemInform Abstract: Unravelling the Proton Conduction Mechanism from Room Temperature to 553 K in a 3D Inorganic Coordination Framework.
Authors: Wang Yaxing , Tao Zetian , Yin Xuemiao , Shu Jie , Chen Lanhua , Sheng Daopeng , Chai Zhifang , Albrecht‐Schmitt Thomas E. , Wang Shuao 
Published: December 2015

AbstractHNd(IO3)4 is prepared by hydrothermal reaction of Nd2O3, H5IO6, and H2O (autoclave, 160 °C, 3 d).
ChemInform Abstract: Synthesis of Novel Book‐Like K0.23V2O5 Crystals and Their Electrochemical Behavior in Lithium Batteries.
Authors: Xu Maowen , Han Jin , Li Guannan , Niu Yubin , Liu Sangui , Hou Junke , Wang Minqiang , Song Jie , Li Chang Ming 
Published: December 2015

AbstractK0.23V2O5 crystals are obtained by hydrothermal reaction of an aqueous solution of NH4VO3 and KSCN (autoclave, 210 °C, 1 d) followed by staged calcination of the precipitate in air (400, 450, and 500 °C, 4 h per stage).
ChemInform Abstract: Zintl‐Phase Sr3LiAs2H: Crystal Structure and Chemical Bonding Analysis by the Electron Localizability Approach.
Authors: Feng Xian‐Juan , Prots Yurii , Bobnar Matej , Schmidt Marcus Peter , Schnelle Walter , Zhao Jing‐Tai , Grin Yuri 
Published: December 2015

AbstractSr3LiAs2H is prepared by melting and sintering of the elements and LiH in the molar ratio of Sr:LiH:Li:As = 3:1:1:2 (Ta crucible, 1.
ChemInform Abstract: Thiazyl Trifluoride (NSF3) Adducts and Imidodifluorosulfate (F2OSN‐) Derivatives of Hg(OTeF5)2.
Authors: DeBackere John R. , Mercier Helene P. A. , Schrobilgen Gary J. 
Published: December 2015

AbstractReactions of Hg(OTeF5)2 with excess amounts of NSF3 in SO2ClF or Freon‐114 (FEP reaction vessel, 0 °C, 2 d) result in the formation of NSF3 adducts of the compositions [Hg(OTeF5)2·NSF3]∞ (I), [Hg(OTeF5)2·2NSF3]2 (II), and Hg3(OTeF5)6·4NSF3 (III).
ChemInform Abstract: A Composite of Complex and Chemical Hydrides Yields the First Al‐Based Amidoborane with Improved Hydrogen Storage Properties.
Authors: Dovgaliuk Iurii , Jepsen Lars H. , Safin Damir A. , Lodziana Zbigniew , Dyadkin Vadim , Jensen Torben R. , Devillers Michel , Filinchuk Yaroslav 
Published: December 2015

AbstractNa[Al(NH2BH3)4] is obtained by ball milling of a NaAlH4‐4AB (AB: NH3BH3) composite under the release of 4.5 wt.% of H2.
ChemInform Abstract: Ba2AsGaSe5: A New Quaternary Selenide with the Novel [AsGaSe5]4‐ Cluster and Interesting Photocatalytic Properties.
Authors: Li Chao , Li Xiaoshuang , Huang Hongwei , Yao Jiyong , Wu Yicheng 
Published: December 2015

AbstractCrystals of Ba2AsGaSe5 are prepared by a solid state reaction of a 4:1:1 molar mixture of BaSe, As2Se3, and Ga2Se3 (evacuated silica tubes, 900 °C, 2 d; cooling to 350 °C at a rate of 3 °C/h).
ChemInform Abstract: Synthesis, Crystal Structures and Properties of Lead Phosphite Compounds.
Authors: Song Jun‐Ling , Hu Chun‐Li , Xu Xiang , Kong Fang , Mao Jiang‐Gao 
Published: December 2015

AbstractThe new compound (III) crystallizes in the orthorhombic space group Cmc21 with Z = 8 (powder XRD).
ChemInform Abstract: Crystallographic, Electronic, and Magnetic Properties of Rock Salt Superstructure Sulfide Lu2CrS4 with Jahn—Teller Distortion.
Authors: Tezuka Keitaro , Wakeshima Makoto , Nozawa Masataka , Oshikane Keita , Ohoyama Kenji , Shan Yue Jin , Imoto Hideo , Hinatsu Yukio 
Published: December 2015

AbstractLu2CrS4 is prepared by solid state reaction of stoichiometric proportions of CrS and Lu2S3 (C‐coated evacuated silica tube, 1300 °C, 24 h).
ChemInform Abstract: New Heterocyclic Product Space for the Castagnoli—Cushman Three‐Component Reaction.
Authors: Dar'in Dmitry , Bakulina Olga , Chizhova Maria , Krasavin Mikhail 
Published: December 2015

AbstractThe use of heteroatom containing analogues of glutaric anhydride in the Castagnoli—Cushman type reaction with imines gives predominately the corresponding trans substituted heterocyclic products.
ChemInform Abstract: Fe(III)‐Catalyzed Trityl Benzyl Ether Formation and Disproportionation Cascade Reactions to Yield Benzaldehydes.
Authors: Cheng Maosheng , et al.  
Published: December 2015

AbstractDepending only on temperature, FeCl3‐catalyzed microwave‐assisted reaction of benzyl alcohols with tritanol gives either the trityl benzyl ethers (III) or benzaldehydes (IV) in high yields.
ChemInform Abstract: CaII‐Catalyzed Alkenylation of Alcohols with Vinylboronic Acids.
Authors: Leboeuf David , Presset Marc , Michelet Bastien , Bour Christophe , Bezzenine‐Lafollee Sophie , Gandon Vincent 
Published: December 2015

AbstractAlkenylation of alcohols with vinylboronic acids is readily achieved in generally moderate to good yields using Ca(NTf2)2 as an air stable catalyst.
ChemInform Abstract: Efficient Synthesis of Nicotinic Acid Based Pseudopeptides Bearing an Amidoxime Function.
Authors: Ovdiichuk Olga V. , Hordiyenko Olga V. , Medviediev Volodymyr V. , Shishkin Oleg V. , Arrault Axelle 
Published: December 2015

Abstract2‐Cyanonicotinic acid reacts with amino acid esters to form pseudoeptides (IV) and (VII) or cyclized products (III).
ChemInform Abstract: Direct Synthesis of Chiral Allenoates from the Asymmetric C—H Insertion of α‐Diazoesters into Terminal Alkynes.
Authors: Tang Yu , Chen Quangang , Liu Xiaohua , Wang Gang , Lin Lili , Feng Xiaoming 
Published: December 2015

AbstractThe title reaction becomes possible in the presence of Cu(I) agents and chiral cationic guanidinium salts.
ChemInform Abstract: Palladium‐Catalyzed Regioselective Hydroalkylation of 2‐Fluoroallyl Acetates: Synthesis of Vinylmalonic Acid Ester Derivatives.
Authors: Kuki Shihori , Futamura Takashi , Suzuki Ryo , Yamamoto Mitsuaki , Minakawa Maki , Kawatsura Motoi 
Published: December 2015

AbstractProducts are preferentially formed as the Z‐isomers whereby the E/Z ratio is strongly dependent on the substitution of the substrates.
ChemInform Abstract: Dinitrogen Extrusion from Enoldiazo Compounds under Thermal Conditions: Synthesis of Donor—Acceptor Cyclopropenes.
Authors: Deng Yongming , Jing Changcheng , Doyle Michael P. 
Published: December 2015

AbstractA convenient, metal‐free protocol for the quantitative transformation of various N‐alkyl and N‐benzyl substituted enoldiazoacetamides into donor‐acceptor cyclopropenes is examined.
ChemInform Abstract: Cationic Iridium/S‐Me‐BIPAM‐Catalyzed Direct Asymmetric Intermolecular Hydroarylation of Bicycloalkenes.
Authors: Shirai Tomohiko , Yamamoto Yasunori 
Published: December 2015

AbstractEspecially, the reactions between 2‐norbornene with N,N‐dialkylbenzamides are highly enantioselective (up to 99% e.e.) and proceed with high selectivity for the mono‐ortho‐arylation product.
ChemInform Abstract: Introduction of Hindered Electrophiles via C—H Functionalization in a Palladium‐Catalyzed Multicomponent Domino Reaction.
Authors: Qureshi Zafar , Schlundt Waldemar , Lautens Mark 
Published: December 2015

AbstractSterically congested 1,2,3‐trisubstituted aromatic compounds are obtained by incorporation of various hindered secondary alkyl iodides starting from a range of aryl iodides via intermolecular Catellani reaction.
ChemInform Abstract: Three‐Component Photoredox‐Mediated Chloro‐, Bromo‐, or Iodotrifluoromethylation of Alkenes.
Authors: Carboni Aude , Dagousset Guillaume , Magnier Emmanuel , Masson Geraldine 
Published: December 2015

AbstractA wide range of terminal and internal styrenes as well as various aliphatic alkenes are utilized for the direct vicinal halotrifluoromethylation using Umemoto′s reagent as the CF3‐ source.
ChemInform Abstract: Conjugate Addition of Diboron Catalyzed by O‐Monoacyltartaric Acids.
Authors: Sugiura Masaharu , Ishikawa Wakoto , Kuboyama Yukinobu , Nakajima Makoto 
Published: December 2015

AbstractA tartaric acid derivative catalyzes the conjugate addition of diboron (III) to α,β‐unsaturated ketones with moderate to good enantioselectivities.
ChemInform Abstract: A Divergent and Selective Synthesis of ortho‐ and para‐Quinones from Phenols.
Authors: Huang Zheng , Kwon Ohhyeon , Esguerra Kenneth Virgel N. , Lumb Jean‐Philip 
Published: December 2015

AbstractA copper(I)‐catalyzed aerobic oxidation of phenols to difunctionalized aryloxy‐ortho‐quinones is described.
ChemInform Abstract: Catalyst‐Free Amidation of Aldehyde with Amine under Mild Conditions.
Authors: Yang Hongyin , Hu Wenjian , Deng Shengjue , Wu Tiantian , Cen Haiman , Chen Yiping , Zhang Dela , Wang Bo 
Published: December 2015

AbstractThe title reaction proceeds in the presence of trichloroisocyanuric acid.
ChemInform Abstract: Highly Stereoselective Intermolecular Haloetherification and Haloesterification of Allyl Amides.
Authors: Soltanzadeh Bardia , Jaganathan Arvind , Staples Richard J. , Borhan Babak 
Published: December 2015

AbstractA broad spectrum of (E) or (Z) configurated allylamide substrates is subjected to the reaction with MeOH in the presence of DCH.
ChemInform Abstract: Remazol‐Catalyzed Hydroperoxyarylation of Styrenes.
Authors: Chen Ying‐Ho , Lee Ming , Lin Yi‐Zhen , Leow Dasheng 
Published: December 2015

AbstractA variety of hydroperoxides are obtained under mild reaction conditions by carbooxygenation of styrenes using RBBR as novel photosensitizer and air as molecular oxygen source.
ChemInform Abstract: Phosphine Oxide Catalyzed, Tetrachlorosilane‐Mediated Enantioselective Direct Aldol Reactions of Thioesters.
Authors: Rossi Sergio , Annunziata Rita , Cozzi Franco , Raimondi Laura Maria 
Published: December 2015

AbstractThe title reaction between aryl substituted thioesters and aryl or hetaryl esters provides the corresponding β‐hydroxy thioesters in moderate yield, with no to excellent diastereomeric and moderate to high enantioselectivity.
ChemInform Abstract: Tandem Blaise/Palladium‐Catalyzed Ullmann Coupling for the One‐Pot Synthesis of Enamino Ester‐Functionalized Biaryls from Nitriles.
Authors: Xuan Zi , Kim Ju Hyun , Lee Sang‐gi 
Published: December 2015

AbstractThe reaction of 2‐bromoarylnitriles (I) with Reformatsky reagent followed by Pd‐catalyzed Ullmann‐type homocoupling of Blaise reaction intermediates affords biaryls (III), which can be easily converted into dibenzo[c,e]azepine derivatives (IV) and (V).
ChemInform Abstract: Synthesis of Polysubstituted γ‐Butenolides via a Radical Pathway: Cyclization of α‐Bromo Aluminium Acetals and Comparison with the Cyclization of α‐Bromoesters at High Temperature.
Authors: Beneteau Romain , Despiau Carole F. , Rouaud Jean‐Christophe , Boussonniere Anne , Silvestre Virginie , Lebreton Jacques , Denes Fabrice 
Published: December 2015

AbstractA four‐step one‐pot procedure involving generation of α‐bromo aluminum acetals, their subsequent radical cyclization followed by oxidation of the resulting cyclic aluminum acetals and base promoted double bond migration is developed to convert α‐bromoesters derived from propargylic alcohols to butenolides.
ChemInform Abstract: Pd‐Catalyzed C(sp3)—H Carbonylation of Alkylamines: A Powerful Route to γ‐Lactams and γ‐Amino Acids.
Authors: Wang Pei‐Long , Li Yan , Wu Yun , Li Chao , Lan Quan , Wang Xi‐Sheng 
Published: December 2015

AbstractThe synthetic utility of the method is demonstrated by its application in the synthesis of racemic pregabalin (IVa).
ChemInform Abstract: One‐Pot Conversion of Carbohydrates into Pyrrole‐2‐carbaldehydes as Sustainable Platform Chemicals.
Authors: Adhikary Nirmal Das , Kwon Sunjeong , Chung Wook‐Jin , Koo Sangho 
Published: December 2015

AbstractCarbohydrates such as glucose (I) are converted into title compounds (III) by the reaction with primary amines (II) in the presence of oxalic acid.
ChemInform Abstract: Asymmetric Synthesis of Fluorinated Isoindolinones Through Palladium‐Catalyzed Carbonylative Amination of Enantioenriched Benzylic Carbamates.
Authors: Barrio Pablo , Ibanez Ignacio , Herrera Lidia , Roman Raquel , Catalan Silvia , Fustero Santos 
Published: December 2015

AbstractDuring the carbonylation process, a significant loss of optical purity is observed for substrates bearing electron withdrawing groups.
ChemInform Abstract: Rh‐Catalyzed Domino Addition—Enolate Arylation: Generation of 3‐Substituted Oxindoles via a Rh(lll) Intermediate.
Authors: Jang Young Jin , Yoon Hyung , Lautens Mark 
Published: December 2015

AbstractRhodium‐catalyzed cyclization reaction of o‐bromoaniline derived acrylamides (I) with various trifluoroborates affords oxindole derivatives in moderate to good yields.
ChemInform Abstract: Palladium‐Catalyzed Heck‐Type Domino Cyclization and Carboxylation to Synthesize Carboxylic Acids by Utilizing Chloroform as the Carbon Monoxide Source.
Authors: Liu Xianglei , Li Bin , Gu Zhenhua 
Published: December 2015

AbstractA wide range of indoline derivatives are synthesized using CHCl3 as convenient and safe alternation for the introduction of the carboxylic acid moiety instead of CO gas.
ChemInform Abstract: A Straight Access to Functionalized Carbazoles by Tandem Reaction Between Indole and Nitrobutadienes.
Authors: Bianchi Lara , Maccagno Massimo , Pani Marcella , Petrillo Giovanni , Scapolla Carlo , Tavani Cinzia 
Published: December 2015

AbstractThe reaction of nitrobutadienes (I) with indole leads to 1,3,4‐ and 1,2,4‐nitrocarbazoles (III) and (IV).
ChemInform Abstract: Eco‐Friendly Chemoselective N‐Functionalization of Isatins Mediated by Supported KF in 2‐MeTHF.
Authors: Mamuye Ashenafi Damtew , Monticelli Serena , Castoldi Laura , Holzer Wolfgang , Pace Vittorio 
Published: December 2015

AbstractThe title method is applicable to a wide range of alkyl halides and acyl donors as well as Michael acceptors.