bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recovery of Stereo Aerial Coverage from 1934 and 1938 into the Digital Era
Authors: Redweik Paula , Garzón Victor , Pereira Teresa sá 
Published: February 2016

AbstractIn the search for historic aerial photographs in the context of a coastal evolution project, the authors accessed a rare collection owned by the Lisbon Port Authority (APL). It had been flown in 1934 and 1938 by the first photogrammetric company in Portugal, Sociedade Portuguesa de Levantamentos Aéreos Limitada (SPLAL). The APL–SPLAL image collection represents a milestone for geomatics in Portugal and is testimony to the high standards of cartographic production at a time when aerial photogrammetry was still evolving as the most efficient method for topographic map production. The recovery of this image collection, together with its derivates, into a digital format was the aim of the present project. Two of the ongoing studies based on these original historic images are also outlined.
Guillain–Barré syndrome associated with resistant cytomegalovirus infection after face transplantation
Authors: Alhefzi M. , Aycart M.A. , Bueno E.M. , Kueckelhaus M. , Fischer S. , Snook R.J. , Sharfuddin A.A. , Hadad I. , Malla P. , Amato A.A. , Pomahac B. , Marty F.M. 
Published: February 2016

AbstractA 39‐year‐old male, who received a facial allograft (cytomegalovirus [CMV] donor‐seropositive, recipient‐seronegative), developed multidrug‐resistant CMV infection despite valganciclovir prophylaxis (900 mg/day) 6 months post transplantation. Lower extremity weakness with upper and lower extremity paresthesias developed progressively 11 months post transplantation, coinciding with immune control of CMV. An axonal form of Guillain–Barré syndrome was diagnosed, based on electrophysiological evidence of a generalized, non‐length‐dependent, sensorimotor axonal polyneuropathy. Treatment with intravenous immunoglobulin led to complete recovery without recurrence after 6 months.
An Update on the Streptococcus bovis Group: Classification, Identification, and Disease Associations
Authors: Dekker John P. , Lau Anna F. 
Published: February 2016

ABSTRACT

The
Streptococcus bovis
group has undergone significant taxonomic changes over the past 2 decades with the advent of new identification methods with higher discriminatory power. Although the current classification system is not yet embraced by all researchers in the field and debate remains over the performance of molecular techniques for identification to the species level within the group, important disease associations for several members of the group have been clarified. Here, we provide a brief overview of the history of the
S. bovis
group, an outline of the currently accepted classification scheme, a review of associated clinical syndromes, and a summary of the performance and diagnostic accuracy of currently available identification methods.
Staphylococcus chromogenes, a Coagulase-Negative Staphylococcus Species That Can Clot Plasma
Authors: dos Santos Danielle Cabral , Lange Carla Christine , Avellar-Costa Pedro , dos Santos Katia Regina Netto , Brito Maria Aparecida Vasconcelos Paiva , Giambiagi-deMarval Marcia 
Published: February 2016

ABSTRACT

Staphylococcus chromogenes
is one of the main coagulase-negative staphylococci isolated from mastitis of dairy cows. We describe
S. chromogenes
isolates that can clot plasma. Since the main pathogen causing mastitis is coagulase-positive
Staphylococcus aureus
, the coagulase-positive phenotype of
S. chromogenes
described here can easily lead to misidentification.
Neuraminidase Activity and Resistance of 2009 Pandemic H1N1 Influenza Virus to Antiviral Activity in Bronchoalveolar Fluid
Authors: Ruangrung Kanyarat , Suptawiwat Ornpreya , Maneechotesuwan Kittipong , Boonarkart Chompunuch , Chakritbudsabong Warunya , Assawabhumi Jirawatna , Bhattarakosol Parvapan , Uiprasertkul Mongkol , Puthavathana Pilaipan , Wiriyarat Witthawat , Jongkaewwattana Anan , Auewarakul Prasert 
Published: February 2016

ABSTRACTHuman bronchoalveolar fluid is known to have anti-influenza activity. It is believed to be a frontline innate defense against the virus. Several antiviral factors, including surfactant protein D, are believed to contribute to the activity. The 2009 pandemic H1N1 influenza virus was previously shown to be less sensitive to surfactant protein D. Nevertheless, whether different influenza virus strains have different sensitivities to the overall anti-influenza activity of human bronchoalveolar fluid was not known. We compared the sensitivities of 2009 pandemic H1N1, seasonal H1N1, and seasonal H3N2 influenza virus strains to inhibition by human bronchoalveolar lavage (BAL) fluid. The pandemic and seasonal H1N1 strains showed lower sensitivity to human BAL fluid than the H3N2 strains. The BAL fluid anti-influenza activity could be enhanced by oseltamivir, indicating that the viral neuraminidase (NA) activity could provide resistance to the antiviral defense. In accordance with this finding, the BAL fluid anti-influenza activity was found to be sensitive to sialidase. The oseltamivir resistance mutation H275Y rendered the pandemic H1N1 virus but not the seasonal H1N1 virus more sensitive to BAL fluid. Since only the seasonal H1N1 but not the pandemic H1N1 had compensatory mutations that allowed oseltamivir-resistant strains to maintain NA enzymatic activity and transmission fitness, the resistance to BAL fluid of the drug-resistant seasonal H1N1 virus might play a role in viral fitness.IMPORTANCEHuman airway secretion contains anti-influenza activity. Different influenza strains may vary in their susceptibilities to this antiviral activity. Here we show that the 2009 pandemic and seasonal H1N1 influenza viruses were less sensitive to human bronchoalveolar lavage (BAL) fluid than H3N2 seasonal influenza virus. The resistance to the pulmonary innate antiviral activity of the pandemic virus was determined by its neuraminidase (NA) gene, and it was shown that the NA inhibitor resistance mutation H275Y abolished this resistance of the pandemic H1N1 but not the seasonal H1N1 virus, which had compensatory mutations that maintained the fitness of drug-resistant strains. Therefore, the innate respiratory tract defense may be a barrier against NA inhibitor-resistant mutants, and evasion of this defense may play a role in the emergence and spread of drug-resistant strains.
A Dimerization-Dependent Mechanism Drives the Endoribonuclease Function of Porcine Reproductive and Respiratory Syndrome Virus nsp11
Authors: Shi Yuejun , Li Youwen , Lei Yingying , Ye Gang , Shen Zhou , Sun Limeng , Luo Rui , Wang Dang , Fu Zhen F. , Xiao Shaobo , Peng Guiqing 
Published: February 2016

ABSTRACT
Porcine reproductive and respiratory syndrome virus (PRRSV) RNA endoribonuclease nsp11 belongs to the XendoU superfamily and plays a crucial role in arterivirus replication. Here, we report the first crystal structure of the arterivirus nsp11 protein from PRRSV, which exhibits a unique structure and assembles into an asymmetric dimer whose structure is completely different from the hexameric structure of coronavirus nsp15. However, the structures of the PRRSV nsp11 and coronavirus nsp15 catalytic domains were perfectly superimposed, especially in the “active site loop” (His129 to His144) and “supporting loop” (Val162 to Thr179) regions. Importantly, our biochemical data demonstrated that PRRSV nsp11 exists mainly as a dimer in solution. Mutations of the major dimerization site determinants (Ser74 and Phe76) in the dimerization interface destabilized the dimer in solution and severely diminished endoribonuclease activity, indicating that the dimer is the biologically functional unit. In the dimeric structure, the active site loop and supporting loop are packed against one another and stabilized by monomer-monomer interactions. These findings may help elucidate the mechanism underlying arterivirus replication and may represent great potential for the development of antiviral drugs.

IMPORTANCE
Porcine reproductive and respiratory syndrome virus (PRRSV) is a member of the family
Arteriviridae
, order
Nidovirales
. PRRSV is a major agent of respiratory diseases in pigs, causing tremendous economic losses to the swine industry worldwide. The PRRSV nsp11 endoribonuclease plays a vital role in arterivirus replication, but its precise roles and mechanisms of action are poorly understood. Here, we report the first dimeric structure of the arterivirus nsp11 from PRRSV at 2.75-Å resolution. Structural and biochemical experiments demonstrated that nsp11 exists mainly as a dimer in solution and that nsp11 may be fully active as a dimer. Mutagenesis and structural analysis revealed NendoU active site residues, which are conserved throughout the order
Nidovirales
(families
Arteriviridae
and
Coronaviridae
) and the major determinants of dimerization (Ser74 and Phe76) in
Arteriviridae
. Importantly, these findings may provide a new structural basis for antiviral drug development.
Can We Conclude an Arctic Treaty? – Historical Windows of Opportunity
Authors: Koivurova Timo 
Published: February 2016

This article examines moments of opportunity when non-governmental organisations (NGOS), inter-governmental organisations (IGOS), the European Union or nation-states have shown interest in discussing or commissioning studies on a comprehensive Arctic Treaty as a way to govern the region.These ‘windows of opportunity’ moments will be studied chronologically, starting from the end of the Cold War and progressing to the present day. It is also interesting to examine these proposals and their positioning against the current landscape of Arctic and global governance. The article will then examine how the region’s nation-states and other actors have actually opted to meet the challenges of this intensely transforming region, asking whether the states or other authoritative actors have been in favour of a comprehensive Arctic Treaty or if they have preferred to adopt some other solutions in respect to Arctic policy and law. Finally, it is of interest to examine the possible ways forward in governing a region that is undergoing dramatic transformation due to climate change and economic globalisation.
Relationship Between Individualized Training Impulse and Aerobic Fitness Measures in Hurling Players Across a Training Period
Authors: Malone Shane , Collins Kieran 
Published: February 2016

Abstract
Malone, S and Collins, K. Relationship between individualized training impulse and aerobic fitness measures in Hurling players across a training period. J Strength Cond Res 30(11): 3140–3145, 2016—The current study examined the association between individual internal training load (individualized training impulse, iTRIMP) and aerobic fitness variables in male hurling players. Twenty hurling players (age, 25.5 ± 3.2 years; height, 178.9 ± 3.2 cm; body mass, 78.5 ± 4.5 kg) performed treadmill testing for V̇o
2max, running economy (RE), and the speed at blood lactate concentrations of 2 mmol·L−1 (S2) and 4 mmol·L−1 (S4) on separate occasions before and after an 8-week training period. The Yo-Yo intermittent recovery (Yo-YoIR1, Yo-YoIR2) test performance were also assessed before and after the training period. Individualized training impulse was calculated using the blood lactate and heart rate profile of each individual player and was further assessed for each training session across the intervention period (n = 990). The results showed that iTRIMP had large to very large association with the percentage improvements in V̇o
2max (r = 0.77; p = 0.002; 95% confidence interval [CI], 0.38–0.93, very large), RE (r = 0.78; p = 0.002; 95% CI, 0.40–0.93; very large), S2 (r = 0.64; p = 0.004; 95% CI, from 0.25 to 0.85; large), S4 (r = 0.78; p = 0.003; 95% CI, 0.45–0.85; very large), Yo-YoIR1 (r = 0.69; p = 0.003; 95% CI, 0.45–0.92; large), and Yo-YoIR2 (r = 0.60; p = 0.005; 95% CI, 0.45–0.92; large) performance. The study shows that iTRIMP is a means of quantifying training load in team sports and can be used to prescribe training for the maintenance or improvement of aerobic fitness during the competitive season with strong relationships seen between weekly iTRIMP measures and improvements in aerobic fitness measures.
André Maurois et la tradition moraliste française
Authors: Laurent Thierry 
Published: February 2016

André Maurois (1885–1967) fut, jusqu’à sa mort, l’un des écrivains les plus lus et les plus respectés de sa génération, tant en France qu’à l’étranger (on l’appréciait d’ailleurs autant en Amérique qu’en Union soviétique !). Sa notoriété comme romancier, essayiste, historien, biographe, journaliste, conférencier et académicien l’amena à beaucoup voyager (surtout dans les pays anglo-saxons) et à se lier d’amitié avec de grands esprits (tels Paul Valéry ou Rudyard Kipling) ou quelques-uns des acteurs politiques majeurs de l’entre-deux-guerres (Aristide Briand, Winston Churchill, Edouard Herriot). Il n’empêche qu’aujourd’hui on a un peu oublié cet ancien auteur à succès et que son oeuvre ne séduit plus guère la jeunesse. Le milieu universitaire français l’ignore ou le traite avec condescendance et la plupart de ses écrits ne sont plus réédités. Comprenons que comme Anatole France, Roger Martin du Gard ou Georges Duhamel, il incarne à la fois l’humanisme bourgeois et l’attachement à la culture classique, valeurs plutôt dénigrées ou démodées depuis la seconde moitié du vingtième siècle ; ajoutons-y le conservatisme politique et son côté « psychologue mondain » » qui ont pu aussi lui faire du tort a posteriori ; le fait d’être un brillant polygraphe ou une « machine à livres » n’a jamais été rare, mais aujourd’hui, cela inspire peut-être davantage de méfiance ; et enfin, quelque plaisir que l’on ait à savourer sa prose élégante, il faut bien reconnaître que son style assez châtié semble un tantinet désuet.
Observations on Some Technical Terms in the *Vimuttimagga and their English Translations: An Examination of Ji? (?) and Visayappavatti
Authors: Kim Kyungrae 
Published: February 2016

In the Chinese text of the *Vimuttimagga, namely the Ji?tu? dào lùn (????), the word ji? (?) is used as a technical abhidhamma term. It is used to refer to an initial cognitive activity through the five material sense organs. In the published English translation, the term is not understood clearly.
There are similarities and differences between the two terms, ji? (?)and visayappavatti. They are linked to similar doctrinal structures and technical terminology, especially the concept of bhava?ga, which is a distinctive doctrine of Sri Lankan Therav?da. On the other hand, visayappavatti implies an initial cognitive activity by any of the six sense organs, while the term ji? refers to an initial cognitive activity only through the five material sense organs.
A comparative study of the two terms proposes the following implications. Firstly, the text *Vimuttimagga is related to Sri Lankan P?li abhidhamma because the orientation of the two terms is more than similar. Secondly, the text represents an early phase of the extant P?li abhidhamma because the term ji? is less mature terminology than the term visayappavatti.
A Phase II Study of FOLFOXIRI Plus Panitumumab Followed by Evaluation for Resection in Patients With Metastatic KRAS Wild-Type Colorectal Cancer With Liver Metastases Only
Authors: Bendell Johanna C. , Zakari Ahmed , Peyton James D. , Boccia Ralph , Moskowitz Mark , Gian Victor , Lipman Andrew , Waterhouse David , LoCicero Richard , Earwood Chris , Lane Cassie M. , Meluch Anthony 
Published: February 2016

Abstract

Lessons Learned
This regimen is a viable option for patients with liver-only metastatic colorectal cancer. Enrollment criteria for future studies should include testing for the newly identified KRAS mutations.

Background.
Patients with liver-only metastatic colorectal cancer (mCRC) who are not candidates for potentially curative resection may become resectable with more aggressive chemotherapy regimens. In this nonrandomized trial, we evaluated folinic acid, 5-fluorouracil (5-FU), oxaliplatin, and irinotecan (FOLFOXIRI) plus the epidermal growth factor receptor inhibitor panitumumab as first-line treatment for KRAS wild-type mCRC with liver-only metastasis.

Methods.
Patients received FOLFOXIRI (5-FU, 3,200 mg/m2, 48-hour continuous intravenous (i.v.) infusion; leucovorin, 200 mg/m2 i.v.; irinotecan, 125 mg/m2; oxaliplatin, 85 mg/m2 i.v.) and panitumumab (6 mg/kg i.v.) on day 1 of 14-day cycles. Patients were restaged and evaluated for surgery every four cycles. Planned enrollment was originally 49 patients. The primary endpoint was objective response rate.

Results.
Fifteen patients (median age: 55 years; 87% male) received a median 6 cycles of treatment (range: 1–33 cycles); 10 patients (67%) were surgical candidates at baseline. Twelve patients were evaluable for clinical response; 9 (60%) achieved partial response. Ten patients underwent surgery; all had complete resections and pathologic partial response. Treatment-related grade 3 adverse events included diarrhea (33%) and rash (20%). Enrollment was halted because of emerging data on expanded KRAS/NRAS mutations beyond the region we initially examined, and the potential for negative interaction with oxaliplatin-based therapy. Eight patients underwent expanded KRAS/NRAS analysis outside exon 2; no additional mutations were found.

Conclusion.
KRAS/NRAS mutations outside the region tested in this study were recently shown to be associated with inferior survival on similar treatment regimens. Therefore, this trial was stopped early. This regimen remains a viable option for patients with liver-only mCRC in the KRAS/NRAS wild-type population. Enrollment criteria on future studies should include testing for the newly identified mutations.
Frequency and severity of mental disorders in patients with non-organic chest pain and factors contributing to it, 2013
Authors: Zamani Bijan , Sadeghi Movahhed Fariba , Hoseini Zohreh , Zamani Negin 
Published: February 2016

<p class="abstract"><strong><span lang="EN-US">Background:</span></strong><span lang="EN-US"> One of the most frequent causes of patients' visiting cardiovascular clinics is chest pain either with cardiac or non-cardiac reason. The cause of non-cardiac chest pain can be corporeal (such as esophageal, respiratory, or musculoskeletal) or mental. Mental factors that are mostly treated negligently can cause or worsen vascular diseases. This study was conducted with the purpose of determining the frequency and severity of mental disorders in patients with non-organic chest pain and its contributors. </span></p><p class="abstract"><strong><span lang="EN-US">Methods: </span></strong>This descriptive cross sectional study was carried out over195 patients with chest pain visiting Ardabil Imam Hospital. Data were collected by SCL-90-Rquestionaire and then analysed by statistical methods using SPSS.19.</p><p class="abstract"><strong><span lang="EN-US">Results:</span></strong><span lang="EN-US"> 41% of patients were men and 59% were women. The most frequent type of mental disorder in this study was somatization with 21.53% and the least frequent one was psychosis with 2%. Somatization intensity was mild in 64.34% of patients, moderate in 19% and severe in16.6%. The highest level of frequency for mental disorders was seen among women and those aged between 30 -40.</span></p><p class="abstract"><strong><span lang="EN-US">Conclusions: </span></strong>In this study, mild somatization and anxiety were respectively the most common mental disorders in patients with non-organic chest pain. It was recommended that patients with non-cardiac chest pain, women in particular, be clinically examined by psychiatrists.</p>
A User Survey Finds That a Hospital Library Literature Search Service Has a Direct Impact on Patient Care
Authors: Stovold Elizabeth Margaret 
Published: February 2016

A Review of:
Farrell, A., Mason, J. (2014). Evaluating the Impact of Literature Searching Services on Patient Care Through the Use of a Quick-Assessment Tool. Journal of the Canadian Health Libraries Association, 35(3),116-123. doi: 10.5596/c14-030

Abstract

Objective – To assess the impact of a library provided literature search service on patient care.

Design – Multiple choice questionnaire survey.

Setting – Hospital library.

Subjects – 54 library users who had requested a literature search and indicated the primary purpose of their request was patient care.

Methods – A multiple choice questionnaire survey was designed, building on previously published library impact surveys and best practice guidelines, with input from staff in the local research department. The survey was reviewed by library staff, researchers and prospective respondents and piloted. The survey was sent out with the answers to literature search requests and a small incentive was offered to those who completed the survey. The survey was followed up with reminders.

Main results – The response rate was 57.5% (n=54/94). The most common staff groups requesting literature searches were physicians (33.3%), nurses (22.2%), therapists (16.7%), pharmacists (11.1%) and residents (7.4%). The majority stated that their questions had been answered (77.8%), while 18.5% indicated their questions had been partially answered, for reasons such as the answer leading to more questions, or parts of the question had not been addressed. Two (3.7%) of the respondents’ questions were not answered, either because no answer existed, or because the question didn’t contain enough detail.

Of those who replied that their question had been answered, 64.3% judged the information to have had an immediate impact on patient treatment or management. Other uses of the information included refreshing memory, avoiding an adverse event, diagnosing a patient, or preventing a referral. The percentage of respondents judging there to be no immediate impact on patient care was 16.7%. The impact on diagnosis and treatment was further investigated in those who had said there had been an immediate impact, with 22.2% saying the information determined their choice of drug, 29.6% saying the information confirmed their choice of drug, while 18.5% stated the information changed their choice of drug. All respondents replied that they intended to use this information in the future, regardless of whether the information had an immediate impact, or if their question had been answered.

Conclusion – The authors concluded that the survey results show hospital libraries can have an impact on patient care through a literature searching service. They also found that the library was answering its literature service users’ questions.
Students with Non-Proficient Information Seeking Skills Greatly Over-Estimate Their Abilities
Authors: Haglund Lotta , Herron David 
Published: February 2016

A Review of:
Gross, Melissa, and Don Latham. "Attaining Information Literacy: An Investigation of the
Relationship between Skill Level, Self-Estimates of Skill, and Library Anxiety." Library & Information Science Research 29.3 (2007): 332-53.

Objective – The objective of this study is an investigation of the relationship between students’ self-assessment of their information literacy skills and their actual skill level, as well as an analysis of whether library anxiety is related to information skill attainment.

Design – Quantitative research design (Information Literacy Test (ILT), Library Anxiety Scale (LAS), pre and post surveys).

Setting – Florida State University, United States.

Subjects – Students, incoming freshmen.

Methods – Information literacy skills were measured using the Information Literacy Test (ILT), presenting subjects with 65 multiple choice items designed around four of the five ACRL information literacy standards, in which students were expected to: 1) determine the nature and extent of the information needed; 2) access needed information effectively and efficiently; 3) evaluate information and its sources critically and incorporates selected information into his/her knowledge base system; 4) understand many of the economic, legal and social issues surrounding the use of information and accesses and uses information ethically and legally. The ILT categorized participant scores as non-proficient (