bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrocalcitonin Is a Novel Pitfall in the Routine of Serum Calcitonin Immunoassay
Authors: Alves Thalita G. , Kasamatsu Teresa S. , Yang Ji H. , Meneghetti Maria Cecília Z. , Mendes Aline , Kunii Ilda S. , Lindsey Susan C. , Camacho Cléber P. , Dias da Silva Magnus R. , Maciel Rui M. B. , Vieira José Gilberto H. , Martins João Roberto M. 
Published: December 2015

Context:
Calcitonin (CT) is a sensitive marker of medullary thyroid carcinoma (MTC) and is used for primary diagnosis and follow-up after thyroidectomy. However, persistently elevated CT is observed even after complete surgical removal without evidence of a recurrent or persistent tumor.

Objective:
To investigate the presence of assay interference in the serum CT of MTC patients who are apparently without a structural disease.

Patients and Methods:
We studied three index MTC cases for CT assay interference and 14 patients with metastatic MTC. The CT level was measured using an immunofluorometric assay. Screening for assay interference was performed by determination of CT levels before and after serum treatment with polyethylene glycol. Additionally, samples were analyzed by chromatography on ultra-performance liquid chromatography and protein A-Sepharose.

Results:
Patients with biochemical and structural disease showed CT mean recovery of 84.1% after polyethylene glycol treatment, whereas patients suspected of interference showed recovery from 2–7%. The elution profile on UPLC showed that the immunometric CT from these three patients behaved like a high molecular mass aggregate (&gt;300 kDa). Additionally, when these samples were applied to the protein A-Sepharose, CT immunoreactivity was retained on the column and was only released after lowering the pH.

Conclusions:
For the first time, our results show the presence of a novel pitfall in the CT immunoassay: “macrocalcitonin.” Its etiology, frequency, and meaning remain to be defined, but its recognition is of interest and can help clinicians avoid unnecessary diagnostic investigations and treatment during the follow-up of MTC.
Shocked and guilty, but highly motivated: Younger patients' experience post MI
Authors: McAnirn Gemma , Lusk Lisa , Donnelly Patrick , McKenna Niall , Hamill Conal , Fitzsimons Donna 
Published: December 2015

Background: Prevalence of myocardial infarction (MI) is increasing in younger patients. These patients have distinct needs post MI and are also the poorest attenders at cardiac rehabilitation (CR). Little is known about how younger patients come to terms with their diagnosis, evaluate their personal risk and motivate themselves for lifestyle change. Aim: The aim of the study is to explore the issues encountered by younger patients, who have families, as they attempt lifestyle changes post MI. Methods: A Heideggerian phenomenological methodology employing semi-structured interviews was used with participants (n=7), 6–8 weeks following discharge from hospital. All participants were diagnosed with an MI for the first time, were <50 years of age and had dependent children. Framework analysis was used to identify themes within the interviews. Results: Five major themes were identified: guilt, grief, disbelief, motivation for change, and family support and involvement in lifestyle change. Post MI, family responsibilities were a strong motivator for survival and lifestyle change. The participants were keen to live healthier lives, improve their risk profile and encourage others to do the same. Conclusion: This study confirms the importance of considering the patient's age and family responsibilities within the setting of preventative cardiology. A more patient-centred and tailored approach to CR is needed with younger patients to improve uptake owing to their lifestyle and family commitments. There is need for further research in the acceptability of the current provision of CR.
Jordanian client perspectives of substance abuse: Implications for occupational therapists
Authors: Abu Tariah Hashem S , Hamed Razan T , Al-Omari Hassan D 
Published: December 2015

Background/Aims: Substance abuse is a global health problem with harmful consequences for the individual, family and society. This study explored the personal factors contributing to substance abuse from the perspective of Jordanian clients and its implications for occupational therapy. Methods: An exploratory qualitative study was conducted using a questionnaire with nine open-ended questions to explore participants' experience of their illness and recovery. Inductive content analysis was used to analyse data. Results: Participants were 146 Jordanian substance abuse clients (142 male) with a mean age of 28 years. Five main themes emerged: fears; personal traits; helpers; speaking out; the best solution. Conclusions: Occupational therapists might design client-centred interventions for substance abuse where they consider the perspectives of clients with regard to the personal traits that contribute to their recovery. Occupational therapy services that take an interdisciplinary team approach are recommended for clients diagnosed with substance abuse.
Multi-response Optimization in Wire Electrical Discharge Machining (WEDM) of Al6061/SiCp Composite Using Hybrid Approach
Authors: Anand Babu K. , Venkataramaiah P. 
Published: December 2015

AbstractIn recent days, the silicon carbide particulate reinforced aluminium metal matrix composites are most promising material in various engineering applications due to their strength to weight ratio, wear resistance and thermal resistance over the non-reinforced alloys. However, these materials are very difficult to cut by conventional machining methods due to the presence of silicon carbide particles. To overcome this limitation, the wire electrical discharge machining (WEDM) is employed to machine these composites. The aim of this study is to optimize the process parameters in wire electrical discharge machining (WEDM) of Al6061/SiCp composite using AHP-TOPSIS method. Al 6061/2% SiCp/3 µm particulate metal matrix composite is fabricated by using stir casting method and the uniformity of particle distribution was analyzed by SEM. Taguchi L18 orthogonal array is designed by considering various process parameters viz. Wire Type (WT), Pulse ON Time (T ON), Pulse OFF Time (T OFF), Wire Feed rate (WF) and Sensitivity (S) for conducting WEDM experiments. The obtained experimental results were analyzed and the results revealed that Sensitivity (S) is the prevailing factor on the response characteristics of WEDM followed by pulse ON time (T ON), wire feed rate (WF), Wire Type (WT) and pulse OFF time (T OFF).
Habitat altitude and home range of the endangered long-tailed goral (Naemorhedus caudatus): seasonal and monthly home range and altitude change
Authors: Cho Cheaun , Kim Kyucheol , Kwon Guhui 
Published: December 2015

AbstractWith data from GPS collars, we analyzed the behavioral characteristics of the endangered long-tailed goral (n=10) in three locations (Seoraksan and Woraksan National Park, and the Uljin area), from March 2007 to May 2014. We found significant differences in the seasonal home range size of females, but not in males. Additionally, females significantly differed in their habitat altitudes depending on the season, with higher altitude habitats used in the summer and lower altitude habitats used in the winter. Males also exhibited this pattern, but it was not significant. Thus, males’ seasonal home range was largest in summer and the smallest in spring, but females’ home range was largest in spring and autumn and smallest in summer and winter. In monthly home range, male’s home range was largest in October to November during their mating season, the size of female’s home range dramatically decreased in May, June, July due to giving birth. In habitat characteristics, seasonal and monthly use of altitude was highest in summer and lowest in winter for both of males and females. So, we found that there were differences in seasonal and monthly habitat use for both of males and females. Our findings will contribute to a better understanding of long-tailed goral restoration ecology.
Ultrafast photoinduced carrier dynamics at ZnO nanohybrid interfaces for light-harvesting applications
Authors: Sardar Samim , Pal Samir Kumar 
Published: December 2015

AbstractThe use of nanoscale materials for efficient solar light harvesting has attracted immense attention in the recent time in order to address the energy and environmental issues. Among them, semiconductor materials such as ZnO have been widely used in the field of photocatalysis and dye-sensitized solar cells (DSSC). However, due to limited visible-light activity and low photo-conversion efficiency, ZnO needs to be modified to design heterostructures with efficient charge separation. Several strategies have been made to modify the wide-bandgap semiconductors including narrow-bandgap semiconductor coupling, noble metal deposition, conducting polymer sensitization and organic dye sensitization. However, the activity of such heterogeneous systems critically depends on the charge dynamics across the involved nanostructured interface. The present review is an effort to unravel the ultrafast dynamical processes across the interface of heterostructures to enhance the solar light-harvesting efficiency. Here, we have discussed few of our selected results covering the different modification strategies of the ZnO nanostructures. The special emphasis has been given to the correlation between the ultrafast processes at the interface and their implications in the light-harvesting applications. The detailed spectroscopic investigations revealing electronic pathways for light harvesting will be helpful in designing future solar devices.
Comparative biological evaluation between 99mTc tricarbonyl and 99mTc-Sn(II) levosalbutamol as
a β
2-adrenoceptor agonist
Authors: Sanad Mahmoud H. , Borai Emad H. 
Published: December 2015

Abstract
This study describes the comparison between 99mTc-tricarbonyl and 99mTc-Sn (II) levosalbutamol
as a β
2-adrenoceptors radiopharmaceutical and evaluation of their different biological characteristics using experimental
animals. Levosalbutamol was labeled firstly with 99mTc in the presence of SnCl2 · 2H2O as a reducing
agent under the optimum conditions: pH 8, 50 μg SnCl2 · 2H–2O, room temperature, 40 μg
levosalbutamol and 30 min reaction time to give a maximum radiochemical yield of 98 ± 0.1%. The
obtained 99mTc-levosalbutamol was stable for a time up to 8 h. Secondly,
99mTc-tricarbonyl ([99mTc(CO)3(H2O)3]+) levosalbutamol was prepare under
30 min heating at 100 ℃. Labeling yield and stability were analyzed by high performance liquid
chromatography (labeling yield >99% and stability for 8 h). Biodistribution investigation showed that,
the maximum uptake ratio of the 99mTc-levosalbutamol (99mTc-Lev) between lung and heart was
2.34 ± 0.62 % of the injected activity/g tissue organ, at 30 min post-injection. But in case of
99mTc-tricarbonyl levosalbutamol (99mTc-tricarbonyl Lev) the maximum uptake ratio was
3.6 ± 0.11of the injected activity/g tissue organ, at 30 min post-injection. This indicates that
99mTc-tricarbonyl levosalbutamol was more selective for lung β
2-adrenoceptors than
99mTc-levosalbutamol. These results introduce 99mTc-tricarbonyl levosalbutamol as a novel
potential radiopharmaceutical for lung imaging.
High order approximations in space and time of a sixth order Cahn–Hilliard equation
Authors: Boyarkin Oleg , Hoppe Ronald H. W. , Linsenmann Christopher 
Published: December 2015

AbstractWe consider an initial-boundary value problem for a sixth order Cahn-Hilliard equation describing the formation of microemulsions. Based on a Ciarlet-Raviart type mixed formulation as a system consisting of a second order and a fourth order equation, the spatial discretization is done by a C
The Caenorhabditis elegans Ephrin EFN-4 Functions Non-cell Autonomously with Heparan Sulfate Proteoglycans to Promote Axon Outgrowth and Branching
Authors: Schwieterman Alicia A , Steves Alyse N , Yee Vivian , Donelson Cory J , Bentley Melissa R , Santorella Elise M , Mehlenbacher Taylor V , Pital Aaron , Howard Austin M , Wilson Melissa R , Ereddia Danielle E , Effrein Kelsie S , McMurry Jonathan L , Ackley Brian D , Chisholm Andrew D , Hudson Martin L 
Published: December 2015

Abstract
The Eph receptors and their cognate ephrin ligands play key roles in many aspects of nervous system development. These interactions typically occur within an individual tissue type, serving either to guide axons to their terminal targets or to define boundaries between the rhombomeres of the hindbrain. We have identified a novel role for the Caenorhabditis elegans ephrin EFN-4 in promoting primary neurite outgrowth in AIY interneurons and D-class motor neurons. Rescue experiments reveal that EFN-4 functions non-cell autonomously in the epidermis to promote primary neurite outgrowth. We also find that EFN-4 plays a role in promoting ectopic axon branching in a C. elegans model of X-linked Kallmann syndrome. In this context, EFN-4 functions non-cell autonomously in the body-wall muscle and in parallel with HS modification genes and HSPG core proteins. This is the first report of an epidermal ephrin providing a developmental cue to the nervous system.
Locations of Physical Activity as Assessed by GPS in Young Adolescents
Authors: Carlson Jordan A. , Schipperijn Jasper , Kerr Jacqueline , Saelens Brian E. , Natarajan Loki , Frank Lawrence D. , Glanz Karen , Conway Terry L. , Chapman Jim E. , Cain Kelli L. , Sallis James F. 
Published: December 2015

OBJECTIVES:
To compare adolescents’ physical activity at home, near home, at school, near school, and at other locations.

METHODS:
Adolescents (N = 549) were ages 12 to 16 years (49.9% girls, 31.3% nonwhite or Hispanic) from 447 census block groups in 2 US regions. Accelerometers and Global Positioning System devices assessed minutes of and proportion of time spent in moderate to vigorous physical activity (MVPA) in each of the 5 locations. Mixed-effects regression compared MVPA across locations and demographic factors.

RESULTS:
Forty-two percent of adolescents’ overall MVPA occurred at school, 18.7% at home, 18.3% in other (nonhome, nonschool) locations, and 20.6% near home or school. Youth had 10 more minutes (30% more) of overall MVPA on school days than on nonschool days. However, the percentage of location time spent in MVPA was lowest at school (4.8% on school days) and highest near home and near school (9.5%–10.4%). Girls had 2.6 to 5.5 fewer minutes per day of MVPA than boys in all locations except near school.

CONCLUSIONS:
Although a majority of adolescents’ physical activity occurred at school, the low proportion of active time relative to the large amount of time spent at school suggests potential for increasing school-based activity. Increasing time spent in the neighborhood appears promising for increasing overall physical activity, because a high proportion of neighborhood time was active. Increasing youth physical activity to support metabolic health requires strategies for increasing use of physical activity–supportive locations (eg, neighborhoods) and environmental and program improvements in unsupportive locations (eg, schools, homes).
Tradisi Lokal sebagai ‘Urf Progresif
Authors: Harisudin MN 
Published: December 2015

For some, Western culture is not only a form of civilization par excellencebut also a culture that is immune from any critique. Still for some, Western culture is a high culture while other cultures are low cultures. Furthermore, post-colonial studies maintain that Western culture occupies the centre of human civilization while other cultures are at the periphery. The thrust of this latter view is that the Western culture may dominate and rule other cultures. Hence, the real nature of the Western culture is that of hegemony. Now, Western culture has been manifested in many habits and traditions such as pornography, homosexuality, and other form of cultural identity which are malevolent in their nature. In this regard, this paper is interested to show that ‘Urf (local custom) as a framework of analysis commonly used by the scholars of Islam can be appropriated to challenge the hegemonic view of the Western culture and to prove that in fact Western culture can occupy not the centre of human civilization but the periphery.
PENGARUH ESOP, LEVERAGE, AND UKURAN PERUSAHAAN TERHADAP KINERJA KEUANGAN PERUSAHAAN DI BURSA EFEK INDONESIA
Authors: Isbanah Yuyun 
Published: December 2015

ABSTRACTThe purpose of this study was to observe the influence of the ESOP, leverage, and firm size on the financial performance, either simultaneously or partially. Financial performance is measured by return on assets (ROA), return on investment (ROE), and net profit margin (NPM). The sample used in this study is a non-financial companies listed on the Indonesia Stock Exchange and announced the ESOP during the year 2010 to 2013. Methods that use multiple regression analysis. The findings of this study indicate that simultaneous from the ESOP, the size of leverage, and the company has a significant impact on financial performance measured by ROA and NPM. Partially ESOP has no effect on ROE. Leverage and firm size negatively affect ROA. ESOP, leverage, and firm size simultaneously has no effect on the financial performance as measured by ROE. ESOP and leverage partially no effect on ROE. Firm size negatively affect ROE. ESOP and firm size has no effect on NPM. Leverage negative effect on NPM. Based on these results we recommend investors need to consider other factors beyond the studied variables that can be used to describe the maximum performance appraisal. ABSTRAKSITujuan dari penelitian ini adalah untuk mengamati pengaruh ESOP, leverage, dan ukuran perusahaan terhadap kinerja keuangan perusahaan baik secara simultan maupun parsial. Kinerja perusahaan diukur dengan return on assets (ROA), return on investment (ROE), serta net profit margin (NPM). Sampel yang digunakan dalam penelitian ini adalah perusahaan-perusahaan non keuangan yang listing di Bursa Efek Indonesia serta mengumumkan ESOP pada periode 2010 s/d 2013. Metode analisis yang digunakan adalah analisis regresi berganda. Hasil penelitian ini menunjukkan bahwa secara simultan variabel ESOP, leverage, serta ukuran perusahaan berpengaruh terhadap kinerja perusahaan yang diukur dengan ROA dan NPM. Secara parsial ESOP tidak mempunyai pengaruh terhadap ROE. Sedangkan secara parsial leverage serta ukuran perusahaan berpengaruh secara negatif terhadap ROA. ESOP, leverage, serta ukuran perusahaan tidak berpengaruh terhadap kinerja perusahaan yang diukur dengan ROE. ESOP dan leverage secara parsial tidak berpengaruh terhadap ROE. Ukuran perusahaan berpengaruh secara negatif terhadap ROE. ESOP dan ukuran perusahaan tidak berpengaruh terhadapNPM. Leverage berpengaruh secara negatif terhadap NPM. Atas hasil penelitian ini direkomendasikanagar para investor mempertimbangkan faktor-faktor yang lain di luar variabel-variabel penelitian iniyang dapat digunakan untuk menjelaskan penilaian kinerja secara maksimal.
PENGARUH ASIMETRI INFORMASI TERHADAP MANAJEMEN LABA MELALUI MANIPULASI AKTIVITAS RIIL
Authors: Wicaksono Agung 
Published: December 2015

ABSTRACTThis study aims to examine the effect of information asymmetry on earnings management through real activities manipulation. Real activities manipulation was abserved through cash flow from operations. Companies included in LQ-45 Index from from 2009 to 2011 used as sample. Data was obtained from Indonesia Capital Market Directory of Investment Galery of Janabadra University. Results from multiple regression analysis shows that information asymmetry are positive significant for real activities manipulation through cash flow from operations. The results are consistent with Richardson (1998), Roychoduwury (2006), Rahmawati et.al (2006) Deng and Ong (2013), and Lasdi (2013).ABSTRAKSI Penelitian ini bertujuan untuk menguji pengaruh asimetri informasi terhadap manajemen laba melalui manipulasi aktivitas riel. Manipulasi aktivitas riel diamati melalui arus kas operasi. Sampel yang digunakan adalah perusahaan-perusahaan yang tergabung dalam Indeks LQ-45 dari tahun 2009 sampai dengan 2011. Data diperoleh dari Indonesia Capital Market Directory of Investement. Hasil dari analisis regresi berganda menunjukkan bahwa asimetri informasi berpengaruh secara positif signifikan terhadap manipulasi aktivitas riel melalui arus kas operasi. Hasil penelitian ini konsisten dengan temuan Richardson (1998), Roychoduwury (2006), Rahmawati et.al (2006) Deng and Ong (2013), dan Lasdi (2013).
A religião dos celulares: consumo de tecnologia como expressão de fé entre evangélicos e umbandistas
Authors: Silva Sandra Rubia da 
Published: December 2015

<p>Ao longo de onze meses de trabalho de campo em um bairro de camadas populares em Florianópolis, pude constatar importantes conexões entre o consumo de telefones celulares e a vivência da religiosidade entre evangélicos e umbandistas. Neste artigo, exploro as maneiras pelas quais os telefones celulares estão presentes no discurso e nas práticas religiosas desses dois grupos, percebendo o celular tanto como mediador positivo quanto negativo. A partir da análise do material etnográfico, argumento que a associação entre religião e uso de telefones celulares, além de aliviar a experiência da pobreza, traz renovadas possibilidades de expressão da identidade religiosa. Sugiro também que a dimensão política está presente, na medida em que suas funcionalidades – em especial o bluetooth e o SMS - auxiliam na disseminação do discurso religioso e na obtenção de novos adeptos.</p>
Crowdfunding Astronomy Research With Google Sky
Authors: Metcalfe Travis S. 
Published: December 2015

<p>For nearly four years, NASA's Kepler space telescope searched for planets like Earth around more than 150,000 stars similar to the Sun. In 2008 with in-kind support from several technology companies, our non-profit organization established the Pale Blue Dot Project, an adopt-a-star program that supports scientific research on the stars observed by the Kepler mission. To help other astronomy educators conduct successful fundraising efforts, I describe how this innovative crowdfunding program successfully engaged the public over the past seven years to help support an international team in an era of economic austerity. </p>
Identification of organic foulants of nanofiltration membranes used for drinking water production
Authors: Habarou H. , Croué J.P , Heim V. , Franiatte A. , Démocrate C. 
Published: December 2015

The goal of our work was, on the one hand, to characterize and identify the nature of the organic foulants responsible for flux declines of high pressure membranes and to the other hand, to evaluate the efficiency of chemical cleaning.
Thus, membrane autopsy was conducted on nanofiltration membranes isolated before and after cleaning from the Méry-sur-Oise filtration train. Elemental analysis, Pyrolysis GC/MS, FT-IR, 13C- NMR analyses were performed on both insoluble and soluble phases of the deposit extracted from NF modules. Results confirmed the microbial origin of the fouling material. Polysaccharides and aminosugars were found to be the major organic constituents of the fouling material. In addition, the inorganic content (calcium, phosphorous and aluminum as major constituents) was found to increase significantly from stage 1 to stage 3 of the filtration train. After chemical cleaning a significant reduction of the inorganic content was noticed, however the organic composition of the foulant remained almost unchanged.