bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Role of Differentially Expressed Genes and Sex-Specific Genes in Lung Adenocarcinoma: A Transcriptomic Analysis
Authors: Lai Harriet 
Published: September 2024

Lung cancer is a life-threatening disease that affects hundreds of thousands of patients every year. While conventional medicine offers effective treatments for lung cancer, the use of targeted therapy can offer patients a more favorable treatment by being as effective and by minimizing the side effects the patient experiences. The purpose of this research is to identify any differentially expressed or sex-specific genes in lung adenocarcinoma (LUAD) that can act as potential targets for treatment. Using transcriptomic profiles of LUAD tissues from The Cancer Genome Atlas, these profiles are analyzed using the TCGABiolinks library on R. The differentially expressed genes are then used to generate gene ontology, create protein association networks, and identify survival plots of genes using Metascape, STRING, and the Human Protein Atlas respectively. Similar procedures were used for the sex-specific analysis. The gene ontology analysis showed that the TFAP2 family of transcription factors and the PID HNF3B pathway likely promote tumorigenesis in LUAD. Moreover, AGER and SFTPC, genes involved in lung development, were underexpressed in all LUAD samples. Patients with a higher expression of these genes had a higher survival rate than others and can act as potential prognostic markers. In sex-specific genes, it was found that members of the MAGE-A family, a testis antigen family, were highly up-regulated in both males and females. The dysregulation of these genes in females might have a specific role in LUAD progression. These findings can be investigated further to develop better therapies to treat the disease.
Self-Regulatory Strategies as a Means of Counteracting Burnout in Professional Athletes
Authors: Gakh Roman , Kramchenkova Vira , Kuznetsov Oleksiy , Prytula Olesia , Furman Anatolii 
Published: September 2024

Introduction: The social transformations of our time point to the importance of training athletes with due regard for the important achievements of modern training methods. Objectives: The purpose of the proposed article is to study self-regulatory strategies as a means of counteracting burnout in professional athletes. Methods: The realization of the proposed goal involves the use of certain scientific methods, in particular, the content analysis of professional scientific literature, which takes into account both current trends in understanding and notes on the use of individual elements. Results: The results show that self-regulation is important for counteracting burnout symptoms. The processes of self-regulation in the work of athletes are associated with ensuring psychological and physiological comfort during training and performances. Physical self-regulation is the most saturated with self-regulatory practices. It combines control and regulation of muscle tone, control and regulation of movement pace, etc. Social strategies for avoiding burnout are related to support from family, friends and acquaintances. Conclusions: The conclusions note that creating a positive team environment is also a way to counteract burnout.
The Effects of Calcium Gluconate Administration on Potassium Levels of Post Packed Red Cell (PRC) Transfusion Patients with More Than Three-Day-Stored Blood at RSUP Haji Adam Malik, Medan
Authors: Daulay Pardi Mulia , Winata Ade , Irina Rr. Sinta 
Published: September 2024

Background: Blood transfusion is an important and routine medical treatment, especially in cases requiring surgeries such as trauma. One of the biochemical changes that occurs in PRC due to erythrocyte storage is an increase in potassium levels. Hyperkalemia is the most common complication of stored blood transfusion. Cardiac arrest has been widely reported in transfusion-associated hyperkalemia. Methods : This study used a pre-experimental study with a pretest-posttest group design to determine the effects of Ca gluconate administration on blood potassium levels in patients receiving packed red cell (PRC) transfusions with blood stored for > 3 days at RSUP Haji Adam Malik Medan. Results : The distribution of sample characteristics in this study showed a mean age of 46 ± 13.63. There were 7 (22.6%) male and 24 (77.4%) female patients, with a mean BMI of 23.28 ± 6.44. Based on the hemodynamic profile, the mean systolic BP was 105.87 ± 20.59, diastolic BP 70.41 ± 11.94, RR 23.06 ± 2.39 and MAP 83.31 ± 14.48. The mean value of potassium levels before an administration of Ca gluconate was 5.84 ± 0.89, while the mean value after the administration was 5.43 ± 0.90. There were no statistically significant changes in the potassium levels after the administration of Ca gluconate in any samples. Conclusions : There are effects of Ca gluconate administration on the potassium levels of post Packed red cell (PRC) transfusion patients with blood stored for > 3 days at RSUP Haji Adam Malik Medan.
Pesticide Reduction through Organic Farming for Promoting Public Health Management and Food Security
Authors: Anand Utkarsh , Rai Nitin Ranjan 
Published: September 2024

There is a growing global interest in sustainable food consumption to ensure food security. One significant factor driving this demand is the belief that consuming organic food affects Public Health (PH). This research examines the historical context of sustainable agriculture. This article specifically examines the impact of sustainable agriculture on health-related substances, pesticide residues, and contaminants in crops. It also explores the connections between organic food and health indicators. In Organic Farming (OF), the use of pesticides is often restricted or non-existent, which is different from Traditional Farming (TF) methods that heavily depend on pesticides to preserve crops. The notable disparities in pesticide usage between the two agricultural systems profoundly affect the comparative nutritional exposure, hazards, and ecological impacts associated with pesticides. Pesticide Usage Monitoring (PUM) information has been used to compare pesticide usage across organically certified and adjacent traditional farms for tomato crops. This work suggested methods for PR by promoting the widespread use of organic agricultural techniques. Additionally, emphasis on many alternatives available within organic food supply chains to further minimize the usage of pesticides, contact, and adverse effects on workers has been proposed to provide food security.
Secured Public Health data Management Framework using the Internet of Things in a Smart City Environment
Authors: Sinha Anupa , Fatma Eram 
Published: September 2024

The Internet of Things (IoT) is being embraced and impacts various aspects of lives. Integrating IoT technology in the healthcare sector paves the way for continuous remote monitoring of individuals' health status. The healthcare (HC) sector has traditionally produced substantial data. Due to the implementation of the IoT, this quantity has significantly increased. Ensuring proper HC storage is imperative to derive meaningful insights from the data. This study presents a public health (PH) framework that utilizes cloudlets and IoT technology. The primary objective of this PH architecture is to facilitate the retrieval of real-time data by using cloudlets. The research provides and executes an HC data management system to store vast HC data and handle consumer queries to retrieve HC information. The efficacy of the proposed model has been evaluated in terms of data transmission time, energy usage, query response time, and data packet loss. The proposed model outperforms existing PH systems by comparing the assessment findings of the proposed approach with the performance of typical PH systems.
Study on Improvement Plan of Emergency Medical Services Through Information Use on QR Code
Authors: Lee Jei-Young , Kim Jee Hee 
Published: September 2024

The purpose of the study was to diagnose the subjectivity of university students of emergency medical technology (paramedicine) and identify the effects and factors related to each type of QR code. A total of 23 students of paramedicine (emergency medical technology) department filled out the questionnaire after an informed consent. Q survey included 25 statements. Data were analyzed using QUANL program for PC. There were three types in QR code.
Type 1(N= 11) : Effective recognition of information type
Type 2(N=8) : Information related emergency recognition type
Type 3(N=4) : Emergency-patient information application type
Each type had its own differences and characteristics. The analyzed contents showed that there was an overall interconnection among the respondents on how to improve emergency services by use of QR code information.
Sound velocities of olivine at high pressures and temperatures and the composition of Earth's upper mantle
Authors: Zhang Jin S. , Bass Jay D. 
Published: September 2016

AbstractWe present the elastic properties of San Carlos olivine up to P = 12.8(8) GPa and T = 1300(200) K using Brillouin spectroscopy with CO2 laser heating. A comparison of our results with the global seismic model AK135 yields average olivine content near 410 km depth of about 37% and 43% in a dry and wet (1.9 wt % H2O) upper mantle, respectively. These olivine contents are far less than in the pyrolite model. However, comparisons of our results with regional seismic models lead to very different conclusions. High olivine contents of up to 87% are implied by seismic models of the western U.S. and eastern Pacific regions. In contrast, we infer less than 35% olivine under the central Pacific. Strong variations of olivine content and upper mantle lithologies near the 410 km discontinuity are suggested by regional seismic models.
Advances in remote sensing of the daytime ionosphere with EUV airglow
Authors: Stephan Andrew W. 
Published: September 2016

AbstractThis paper summarizes recent progress in developing a method for characterizing the daytime ionosphere from limb profile measurements of the OII 83.4 nm emission. This extreme ultraviolet emission is created by solar photoionization of atomic oxygen in the lower thermosphere and is resonantly scattered by O+ in the ionosphere. The brightness and shape of the measured altitude profile thus depend on both the photoionization source in the lower thermosphere and the ionospheric densities that determine the resonant scattering contribution. This technique has greatly matured over the past decade due to measurements by the series of Naval Research Laboratory Special Sensor Ultraviolet Limb Imager (SSULI) instruments flown on Defense Meteorological Satellite Program (DMSP) missions and the Remote Atmospheric and Ionospheric Detection System (RAIDS) on the International Space Station. The volume of data from these missions has enabled a better approach to handling specific biases and uncertainties in both the measurement and retrieval process that affect the accuracy of the result. This paper identifies the key measurement and data quality factors that will enable the continued evolution of this technique into an advanced method for characterization of the daytime ionosphere.
The role of localized inductive electric fields in electron injections around dipolarizing flux bundles
Authors: Gabrielse Christine , Harris Camilla , Angelopoulos Vassilis , Artemyev Anton , Runov Andrei 
Published: September 2016

AbstractWe study energetic electron injections by using an analytical model that self‐consistently describes electric and magnetic field perturbations of a transient, localized dipolarizing flux bundle (DFB). This simple model reproduces most injection signatures at multiple locations simultaneously, reaffirming earlier findings that an earthward‐traveling DFB can both transport and accelerate electrons to suprathermal energies, and can thus be considered an important driver of short‐lived (~ < 10 min) injections. We find that energetic electron drift paths are greatly influenced by the sharp magnetic field gradients around a localized DFB. Because a DFB is so localized (only a few RE wide across the tail), there are strong duskward magnetic field gradients on the DFB's dawn flank and strong dawnward magnetic field gradients on its dusk flank. Electrons on the DFB's dawnside therefore ∇B drift farther earthward from the reconnection site, whereas electrons on its duskside can potentially evacuate the inner magnetosphere by ∇B drifting tailward. This results in flux decrease at the front's duskside. As a result, the source of electrons observed during injection depends sensitively on the spacecraft location relative to the DFB and on the DFB's properties. We similarly find that the process of electron energization depends on how the electrons interact with the DFB. The initial injection signature is from electrons that interact with the front and gain the majority of their energy from the increasing magnetic field (∂B/∂t), whereas populations that arrive later gain most of their energy from ∇B drifting across the flow channel and against the DFB's electric fields.
Pb2BO3Cl: A Tailor‐Made Polar Lead Borate Chloride with Very Strong Second Harmonic Generation
Authors: Zou Guohong , Lin Chensheng , Jo Hongil , Nam Gnu , You Tae‐Soo , Ok Kang Min 
Published: September 2016

AbstractA meticulously designed, polar, non‐centrosymmetric lead borate chloride, Pb2BO3Cl, was synthesized using KBe2BO3F2 (KBBF) as a model. Single‐crystal X‐ray diffraction revealed that the structure of Pb2BO3Cl consists of cationic [Pb2(BO3)]+ honeycomb layers and Cl− anions. Powder second harmonic generation (SHG) measurements on graded polycrystalline Pb2BO3Cl indicated that the title compound is phase‐matchable (type I) and exhibits a remarkably strong SHG response, which is approximately nine times stronger than that of potassium dihydrogen phosphate, and the largest efficiency observed in materials with structures similar to KBBF. Further characterization suggested that the compound melts congruently at high temperature and has a wide transparency window from the near‐UV to the mid‐IR region.
Microplastic in Aquatic Ecosystems
Authors: Ivleva Natalia P. , Wiesheu Alexandra C. , Niessner Reinhard 
Published: September 2016

AbstractThe contamination of marine and freshwater ecosystems with plastic, and especially with microplastic (MP), is a global ecological problem of increasing scientific concern. This has stimulated a great deal of research on the occurrence of MP, interaction of MP with chemical pollutants, the uptake of MP by aquatic organisms, and the resulting (negative) impact of MP. Herein, we review the major issues of MP in aquatic environments, with the principal aims 1) to characterize the methods applied for MP analysis (including sampling, processing, identification and quantification), indicate the most reliable techniques, and discuss the required further improvements; 2) to estimate the abundance of MP in marine/freshwater ecosystems and clarify the problems that hamper the comparability of such results; and 3) to summarize the existing literature on the uptake of MP by living organisms. Finally, we identify knowledge gaps, suggest possible strategies to assess environmental risks arising from MP, and discuss prospects to minimize MP abundance in aquatic ecosystems.
Preparation, thermostability, and hydrophobic properties ofTiO2/poly(dodecafluoroheptyl methacrylate) nanocomposites
Authors: Xiao Zhenggang , Guo Ping , Sun Na 
Published: September 2016

ABSTRACTPoly(dodecafluoroheptyl methacrylate) (PDFMA)/titanium dioxide (TiO2) nanocomposites with high TiO2content were successfully prepared by emulsion polymerization process. Before polymerization, nano‐TiO2was pretreated by silane coupling agent. Surface groups and composition of the modified nano‐TiO2were characterized by Fourier transform infrared and X‐ray photoelectron spectra. The microstructure of nanocomposites was observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). In addition, the thermo‐stability and wetting behavior were also investigated in relation to the dosage of TiO2. The results showed that the thermostability is improved with the increment of TiO2content while hydrophilic properties exhibit nonlinear variation with the content of TiO2. The optimal percentage of TiO2content in the TiO2/PDFMA nanocomposites is 30% that could lead to the higher thermostability and hydrophobicity properties of composites. The maximum water contact angle (WCA) of nanocomposites can reach 120° ± 1°. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2017,134, 44377.
A new strategy to activate liquid crystal polymer samples for electroless copper deposition
Authors: Atli A. , Simon S. , Cadete Santos Aires F. J. , Cardenas L. , Ehret E. , Lourdin P. 
Published: September 2016

ABSTRACTIn order to activate the polymers for electroless copper deposition, an alternative way of sample preparation is demonstrated. The samples are prepared by incorporation of a small amount (<1 wt %) of palladium, nickel, or copper acetate into the molten Liquid Crystal Polymer (LCP) in a blender. Since the blending temperature is kept higher than the decomposition temperature of acetates, the acetates are thermally decomposed during blending, leading to the metallic Pd, Ni, or Cu which are used as activators for electroless deposition. After preparing the samples, electroless copper deposition is successfully realized. The influence of different acetates (Pd, Ni, or Cu acetates) on the deposition is investigated. The copper amount is higher and the deposition kinetics is faster on LCP samples with 0.15 wt % Pd and 0.4 wt % Ni than that with 0.4 wt % Cu. The deposited copper layers are uniform and oxide‐free. Moreover, the possibility to substitute expensive Pd activator by cheaper Ni or Cu is shown. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44397.
Cranial Ontogeny of the Early Triassic Basal Cynodont Galesaurus planiceps
Authors: Jasinoski Sandra C. , Abdala Fernando 
Published: September 2016

ABSTRACTOntogenetic changes in the skull and mandible of thirty‐one specimens of Galesaurus planiceps, a basal non‐mammaliaform cynodont from the Early Triassic of South Africa, are documented. The qualitative survey indicated eight changes in the craniomandibular apparatus occurred during growth, dividing the sample into three ontogenetic stages: juvenile, subadult, and adult. Changes in the temporal region, zygomatic arch, occiput, and mandible occurred during the transition from the subadult to adult stage at a basal skull length of 90 mm. At least four morphological and allometric differences divided the adult specimens into two morphs, indicating the presence of sexual dimorphism in Galesaurus. Differences include extensive lateral flaring of the zygomatic arches in the “male” morph resulting in a more anterior orientation of the orbits, and a narrower snout in the “female”. This is the first record of sexual dimorphism in a basal cynodont, and the first time it is quantitatively documented in a non‐mammaliaform cynodont. An ontogenetic comparison between Galesaurus and the more derived basal cynodont Thrinaxodon revealed differences in the timing and extent of sagittal crest development. In Galesaurus, the posterior sagittal crest, located behind the parietal foramen, developed relatively later in ontogeny, and the anterior sagittal crest rarely formed suggesting the anterior fibres of the temporalis were less developed than in Thrinaxodon. In contrast, craniomandibular features related to the masseters became more developed during the ontogeny of Galesaurus. The development of the adductor musculature appears to be one of the main factors influencing skull growth in these basal non‐mammaliaform cynodonts. Anat Rec, 300:353–381, 2017. © 2016 Wiley Periodicals, Inc.
Immunohistochemical Localization of Somatostatin in the Brain of Chinese Alligator Alligator sinensis
Authors: Wang Huan , Zhang Ruidong , Zhang Shengzhou , Zhou Yongkang , Wu Xiaobing 
Published: September 2016

ABSTRACTIn this study, the regional distribution and histological localization of somatostatin (SS) immunoreactive (IR) perikarya and fibers was investigated for the first time in the brain of adult Chinese alligator by immunohistochemical method. The results showed SS‐IR perikarya and fibers were widely distributed in various parts of the brain except for olfactory bulbs. In the telencephalon, SS‐IR perikarya were predominantly located in the cellular layer and deep plexiform layer of dorsomedial and medial cortex, less in the dorsal and lateral cortex, while SS‐IR fibers were found in all layers of the cerebral cortex. SS‐IR perikarya and fibers were also detected in the dorsal ventricular ridge, hippocampus cortex, accessory olfactory bulb nuclearus, lenticular nucleus, and caudate nucleus. In the diencephalon, SS‐IR perikarya and fibers were mainly present in supraoptic nucleus, paraventricular nucleus of hypothalamus, recessus infundibular nucleus, median eminence, the pineal gland and pituitary gland, in which the IR‐fibers were abundant, appearing dot‐shaped and varicosity‐like. In the mesencephalon, they were present in tectum cortex, ependyma of cerebral aqueduct and the periaqueductal grey matter. Additionally, they were also detected in Purkinje's cellular layer of cerebellum, in the reticularis nucleus and raphe nucleus of medulla oblongata. The distribution pattern of SS‐IR perikarya and fibers in the brain of Chinese alligator is generally similar to that reported in other reptiles, but also has some specific features. The wide distribution indicated that SS might be a neurotransmitter or neuromodulator which acts on many kinds of target cells with a wide range of physiological functions. Anat Rec, 300:507–519, 2017. © 2016 Wiley Periodicals, Inc.
Anisotropic Magnetite Nanorods for Enhanced Magnetic Hyperthermia
Authors: Geng Sai , Yang Haitao , Ren Xiao , Liu Yihao , He Shuli , Zhou Jun , Su Na , Li Yongfeng , Xu Chunming , Zhang Xiangqun , Cheng Zhaohua 
Published: September 2016

AbstractThere is an increasing need for new strategies to improve the heating efficiency or the specific absorption rate (SAR) of magnetite (Fe3O4), which is the only FDA approved magnetic material. We propose a facile approach to obtain well‐dispersed highly crystalline Fe3O4 nanorods (NRs) by the reduction of β‐FeOOH in an organic solvent and demonstrate that the SAR of Fe3O4 NRs can be enhanced by tuning their aspect ratios. Fe3O4 NRs with an aspect ratio of 4.5 have a much higher SAR as compared with 15 nm Fe3O4 nanoparticles and Fe3O4 NRs counterparts with an aspect ratio of 10. The highest SAR is greatly increased up to 1072 W g−1 for an ac field of 33 kA m−1 and a concentration of 5 mg mL−1, which is mostly attributed to hysteresis losses. These findings pave a new pathway for the design and synthesis of novel anisotropic iron oxide nanostructures with an optimal heating efficiency for advanced hyperthermia.