bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelestarian Kawasan Konservasi Pengelolaan Hutan Lindung Dan Penguatan Usaha Desa
Authors: Sa'diyah Ana Arifatus , Widowati Widowati , Khoiriyah Nikmatul 
Published: September 2024

Program pemberdayaan petani hutan untuk konservasi dan restorasi ekosistem yang telah dilakukan oleh Pemdes Jetak Kecamatan Montong kabupaten Tuban pada tahun 2022 dipandang cukup efektif untuk memanfaatkan lahan di bawah tegakan hutan, namun kesinambungan program dalam bentuk pelestarian masih terus diperlukan. Pelestarian kawasan konservasi pengelolaan hutan masih perlu digalakkan agar terjadi keseimbangan ekosistem. Di lain pihak tumbuhnya kelompok usaha baru sebagai sumber penghasilan rumah tangga di luar sektor pertanian (batik, makanan dari produk pertanian, dan pewarna alami batik). Namun masih mengalami beberapa kendala yang berkaitan dengan produksi daun tanaman, manajemen produksi pewarna batik, legal formal ijin usaha, brand produk dan pemasaran digital. Untuk itu perlu penguatan usaha desa sebagai program yang dapat mengatasi kendala tersebut. Di bawah tegakan pohon masih banyak lahan yang pengelolaannya kurang maksimal sehingga berpotensi dikelola untuk tanaman indigofera tinctoria sebagai bahan baku pewarna alami kain batik dengan inovasi teknologi pemupukan yang menerapkan biochar. Program bertujuan untuk mengoptimalkan pemanfaatan lahan dengan budidaya tanaman di bawah tegakan hutan serta penguatan usaha desa. Optimalisasi pemanfaatan lahan dilakukan dengan scalling up agroforestri kopi. Penguatan usaha desa dilakukan dengan pelatihan dan pendampingan legal formal perijinan, branding produk, dan pemasaran digital. Hasil dari program ada penambahan agroforestry kopi dari 3.000 pohon menjadi 4.500 pohon, ada formal legal ijin usaha desa, dan tersedia toko online untuk produk desa. Agar ekosistem hutan lindung terjaga maka program konservasi perlu terus diupayakan. Disamping itu sebagai program keberlanjutan usaha desa, maka Pemdes perlu mendorong pelaku usaha agar memanfaatkan toko online yang tersedia.
Pemberdayaan Petani Dalam Upaya Kemandirian Pupuk Organik Dan Dekomposer Demi Menunjang Keberhasilan Dalam Usaha Tani Desa Kolong, Kecamatan Ngasem, Kabupaten Bojonegoro
Authors: Mangar Irma , Romadhon Nafatio Dwiki , Al Mahdi Sholahudin Ahmed , Aprilia Nanda Dwi , Agustina Ria 
Published: September 2024

Perubahan iklim yang semakin ekstrem dan fluktuasi harga komoditas pertanian juga memperburuk situasi, membuat petani semakin rentan terhadap risiko kehilangan hasil panen. Kurangnya pendidikan dan pelatihan juga menjadi penghalang bagi petani untuk meningkatkan keterampilan dan pengetahuan mereka tentang praktik pertanian yang lebih efisien dan berkelanjutan. Melihat ini sebagai permasalahan yang harus di selesaikan. Oleh karena itu program ini dilaksanakan dengan upaya dapat membantu petani di Desa kolong untuk mengatasi permasalahan yang ada termasuk untuk solusi kemiskinan. Metode ataupun tahapan dan frekuensi kegiatan pada program pengabdian seperti persiapan, survey, kordinasi, pelaksanaan, dan evaluasi. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah membantu petani untuk menghemat biaya pengeluaran pupuk dalam menjalankan usaha tani, kemudian dapat membantu petani untuk lebih bijak lagi dalam menggunakan pupuk, petani di Desa Kolong mampu mandiri dalam membuat pupuk organik.
Жіноче питання та адвокатська діяльність у контексті модернізаційних процесів в Україні у другій половині ХІХ – на початку ХХ ст.
Authors: Котляр Юрій 
Published: September 2024

У статті зроблено спробу показати етапи боротьби жінок за право займатися адвокатською діяльністю в умовах модернізаційних процесів в Україні. Модернізація розглядається як сукупність процесів індустріалізації, секуляризації, бюрократизації, урбанізації, зростання просторової та соціальної мобільності, тобто процесів, які ведуть до формування «відкритого» суспільства. Серед модернізаційних реформ сучасні дослідники виділяють судову реформу 1864 р., яка суттєво вплинула на процес дотримання та захисту прав людини.
Жіноче питання було актуальним в українському суспільстві у другій половині XIX ст. під час модернізації і стало одним із ключових факторів соціального прогресу. Особливе місце у даному контексті займало питання боротьби жінок за право займатися адвокатською діяльністю. Воно так і не було вирішене в межах Російської імперії ні на першому, ні на другому етапах.
Особливості дослідження участі Союзу Визволення України в організації «Константинопольської акції» 1914 року
Authors: Гудзь Віктор , Гасанов Гара огли 
Published: September 2024

Автори статті поставили мету заповнити прогалину у дослідженні наукової літератури про участь Союзу Визволення України у спільному із країнами Четверного союзу проекті висадки десанту на Чорноморському узбережжі Російської імперії та організації там українського повстання. Встановлено, що найбільший внесок у вивчення особливостей участі СВУ в «Константинопольській акції» зробили Б. Сергійчук, І. Патер, М. Несук, а також Х. Киримли (Туреччина), Р. Роздольський (США). Компаративний аналіз досліджень місії СВУ у Стамбулі у 1914 р. дозволив виявити, поряд із здобутками авторів, їх деякі прогалини та недоліки. Так, історики, як правило, аналізують діяльність Союзу з підготовки десанту на Північний Кавказ у 1914 р., тоді як відомі факти про продовження М. Меленевським пошуків варіантів такої експедиції у 1915 р.
Виявлено також некритичне повторення деякими дослідниками неперевірених фактів, як наприклад, про тисячний український десант з числа військовополонених, про причини відмови Австро-Угорщини у співробітництві з СВУ тощо. З’ясовано, що загалом наукові здобутки авторів студій участі СВУ у «Константинопольській акції» є вагомими та сприяють формуванню історичної пам’яті українського народу, поглибленню знань про історію СВУ та українсько-турецькі відносини.
Research progress of piezoelectric materials in protecting oral health and treating oral diseases: a mini-review
Authors: Yang Tingyu , Sa Rina , Wang Furong , Chen Chen , Zheng Lanbing 
Published: September 2024

Piezoelectric materials, as a class of materials capable of generating electrical charges under mechanical vibration, have special piezoelectric effects and have been widely applied in various disease treatment fields. People generate vibrations in the oral cavity during daily activities such as brushing teeth, using electric toothbrushes, chewing, and speaking. These natural vibrations (or external ultrasound) provide ideal conditions for activating piezoelectric materials, leading to their high potential applications in protecting oral health and treating oral diseases. Based on this, this review reports on the research progress and trends of piezoelectric materials in the protection of oral health and the treatment of oral diseases in the past 5 years, and discusses its treatment mechanism, challenges and shortcomings, aiming to provide theoretical basis and new ideas for the future application of piezoelectric materials in the field of oral cavity. Finally, a brief outlook is provided, suggesting that the potential of piezoelectric materials may enable them to quickly move towards real clinical applications.
Therapeutic potential of ADSCs in diabetic wounds: a proteomics-based approach
Authors: Gu Yuan , Mu Zelan , Chen Yuanzheng , Wu Can , Shi Jie , Bai Nan 
Published: September 2024

BackgroundDiabetes mellitus (DM), a chronic metabolic disease characterized by elevated blood sugar, leads to delayed or non-healing wounds, increasing amputation risks, and placing a significant burden on patients and society. While extensive research has been conducted on adipose-derived stem cells (ADSCs) for promoting wound healing, there is a scarcity of studies focusing on diabetic wounds, particularly those employing proteomics and bioinformatics approaches.ObjectiveThis study aimed to investigate the mechanisms by which ADSCs promote diabetic wound healing using proteomics and bioinformatics techniques.MethodsHealthy rat fat tissue was used to isolate ADSCs. A T2DM rat model with back wounds was established. The experimental group received ADSC injections around the wound, while the control group received PBS injections. Wound healing rates were documented and photographed on days 0, 3, 7, 10, and 14. On day 7, wound tissues were excised for HE and Masson’s staining. Additionally, on day 7, tissues were analyzed for protein quantification using 4D-DIA, with subsequent GO and KEGG analyses for differentially expressed proteins (DEPs) and protein-protein interaction (PPI) network analysis using STRING database (String v11.5). Finally, Western blot experiments were performed on day 7 wounds to verify target proteins.Results and ConclusionsIn all measured days postoperatively, the wound healing rate was significantly higher in the ADSC group than in the PBS group (day 7: p &lt; 0.001, day 10: p = 0.001, day 14: p &lt; 0.01), except on day 3 (p &gt; 0.05). Proteomic analysis identified 474 differentially expressed proteins, with 224 key proteins after PPI analysis (78 upregulated and 146 downregulated in the ADSC group). The main cellular locations of these proteins were “cellular anatomical entity” and “protein-containing complex”, while the biological processes were “cellular processes” and “biological regulation”. The primary molecular functions were “binding” and “catalytic activity”, with GO enrichment focused on “Wnt-protein binding”, “neural development”, and “collagen-containing extracellular matrix”. Further analysis of PPI network nodes using LASSO regression identified Thy1 and Wls proteins, significantly upregulated in the ADSC group, as potentially crucial targets for ADSC application in diabetic wound treatment.
A causal association between esophageal cancer and the oral microbiome: a Mendelian randomization study based on an Asian population
Authors: Hu Keke , Huang Ting , Zhang Yiming , Ye Zhifeng , Guo Junhua , Zhou Heran 
Published: September 2024

BackgroundPrevious studies have suggested a crosstalk between the oral microbiome and esophageal cancer (EC), but the exact relationship is unclear. This study aimed to investigate the causal relationship between changes in the oral microbiome and EC by Mendelian randomization (MR).Materials and methodsIn the study, bidirectional MR analyses were conducted using genome-wide association study data from the oral microbiomes from the 4D-SZ cohort and EC data from the BioBank Japan cohort. Multiple sensitivity tests, including Cochrane’s Q statistic, MR-Egger intercept, and MR-PRESSO, were used to assess and validate the relative stability of the resulting data at various levels.ResultsAmong the 3,117 samples studied, 73 oral microbiomes were found to be statistically causally associated with EC, 38 of which were considered protective factors. According to species analyses, positive results were concentrated in three phyla: Firmicutes (29 species), Patescibacteria (18 species), and Actinobacteria (9 species). It was also determined that Parvimonas micra, Aggregatibacter, and Clostridia had a negative causal relationship, implying that EC caused a decrease in the counts. Following p-value correction, periodonticum_C, unclassified_mgs_3234, and unclassified_mgs_45 were identified as having a strong evidence-grade causal relationship with EC. There was no strong evidence in the results of the inverse MR analyses of EC to the oral microbiome. The sensitivity analysis confirmed the robustness of the findings.ConclusionThis study discovered a bidirectional causal relationship between the oral microbiome and EC, which may provide new insights into the future use of the microbiome for early screening and probiotic therapy.
Mechanism of emodin in treating hepatitis B virus-associated hepatocellular carcinoma: network pharmacology and cell experiments
Authors: Wang Yupeng , Li Shuangxing , Ren Tianqi , Zhang Yikun , Li Bo , Geng Xingchao 
Published: September 2024

IntroductionHepatocellular carcinoma (HCC) is a pressing global issue, with Hepatitis B virus (HBV) infection remaining the primary. Emodin, an anthraquinone compound extracted from the natural plant’s. This study investigates the molecular targets and possible mechanisms of emodin in treating HBV-related HCC based on network pharmacology and molecular docking and validates the screened molecular targets through in vitro experiments.MethodsPotential targets related to emodin were obtained through PubChem, CTD, PharmMapper, SuperPred, and TargetNet databases. Potential disease targets for HBV and HCC were identified using the DisGeNET, GeneCards, OMIM, and TTD databases. A Venn diagram was used to determine overlapping genes between the drug and the diseases. Enrichment analysis of these genes was performed using GO and KEGG via bioinformatics websites. The overlapping genes were imported into STRING to construct a protein-protein interaction network. Cytoscape 3.9.1 software was used for visualizing and analyzing the core targets. Molecular docking analysis of the drug and core targets was performed using Schrodinger. The regulatory effects of emodin on these core targets were validate through in vitro experiments.ResultsA total of 43 overlapping genes were identified. GO analysis recognized 926 entries, and KEGG analysis identified 135 entries. The main pathways involved in the KEGG analysis included cancer, human cytomegalovirus infection and prostate cancer. The binding energies of emodin with HSP90AA1, PTGS2, GSTP1, SOD2, MAPK3, and PCNA were all less than -5 kcal/mol. Compared to normal liver tissue, the mRNA levels of XRCC1, MAPK3, and PCNA were significantly elevated in liver cancer tissue. The expression levels of XRCC1, HIF1A, MAPK3, and PCNA genes were closely related to HCC progression. High expressions of HSP90AA1, TGFB1, HIF1A, MAPK3, and PCNA were all closely associated with poor prognosis in HCC. In vitro experiments demonstrated that emodin significantly downregulated the expression of HSP90AA1, MAPK3, XRCC1, PCNA, and SOD2, while significantly upregulating the expression of PTGS2 and GSTP1.ConclusionThis study, based on network pharmacology and molecular docking validation, suggests that emodin may exert therapeutic effects on HBV-related HCC by downregulating the expression of XRCC1, MAPK3, PCNA, HSP90AA1, and SOD2, and upregulating the expression of PTGS2 and GSTP1.
Early detection of chemotherapy-induced cardiotoxicity in breast cancer patients: a comprehensive analysis using speckle tracking echocardiography
Authors: Guo Xuejia , Zhang Ning , Wang Na , Zhang Yanyan , Liu Ya , Pei Miaomiao , Liu Gaiqin , Jia Xinle 
Published: September 2024

IntroductionChemotherapy-induced cardiotoxicity poses a significant challenge in the treatment of breast cancer, potentially compromising both the efficacy of cancer therapy and cardiac health of patients. This study aimed to enhance the early detection of cardiotoxic effects by integrating advanced imaging modalities and biomarker analysis, thereby facilitating timely interventions to mitigate cardiac risk.MethodsA prospective cohort design was employed, enrolling breast cancer patients scheduled for potentially cardiotoxic chemotherapy regimens. The study utilized a comprehensive diagnostic toolkit, including echocardiography with strain imaging, cardiac MRI, and serial measurements of cardiac biomarkers such as high-sensitivity troponins and natriuretic peptides.ResultsThe analysis revealed that subtle changes in myocardial strain parameters and early biomarker elevations were predictive of subsequent declines in left ventricular function, preceding conventional echocardiographic evidence of cardiotoxicity. Logistic regression analysis highlighted the additive predictive value of integrating biomarker data with advanced imaging findings to identify patients with the highest risk of significant cardiotoxicity.DiscussionThe study concluded that an integrated diagnostic approach, combining detailed imaging assessments with sensitive biomarker analysis, offers a superior strategy for the early detection of chemotherapy-induced cardiotoxicity in breast cancer patients. This proactive diagnostic strategy empowers clinicians to tailor cancer therapy more precisely, balancing oncologic efficacy with cardiovascular safety and underscores the importance of a multidisciplinary approach in the management of patients undergoing potentially cardiotoxic chemotherapy.
A systematic review of student learning outcomes in CLIL in LOTE
Authors: Pittas Evdokia , Tompkins Leah 
Published: September 2024

IntroductionThis paper aims to provide a first systematic research overview of student learning outcomes in programs teaching school subjects through languages other than English (LOTE) which are not the mother tongue of the students, according to school- or researcher-administered assessments and stakeholder perspectives, following the PRISMA statement. For brevity, we shall refer to these types of programs as CLIL in LOTE, though we have also included programs which use other labels, such as bilingual education or immersion, due to their similarities with those labeled “content and language integrated learning” (CLIL).MethodsThe selected studies, published between November 1994 and December 2023, were identified through the search of SCOPUS and EBSCO. In determining which studies to include in the review, we employed the following selection criteria: (1) articles focusing on children and youth (ages 5–17 years), (2) articles focusing on CLIL programs in LOTE, (3) articles focusing on student achievement, (4) articles focusing on studies that have collected primary data, and (5) studies that used school−/researcher-administered assessments (objective) or self/ hetero-reported measures (subjective). The screening of titles, abstracts and keywords left a final sample of n = 29 scientific papers, which were then read exhaustively and assessed for methodological quality.ResultsMost studies (26 of 29) addressed academic and/or linguistic outcomes, with some studies additionally addressing social/cultural outcomes, behavioral/affective outcomes, and/or (meta) cognitive outcomes. Of the learning outcomes reported, 25 (53%) were positive, five (11%) were negative, four (9%) were neutral, eight (17%) were mixed and four (9%) identified factors influencing outcomes.DiscussionTheoretically, the study contributes to establishing more general theories about the specific role of CLIL in LOTE in students’ learning. Empirically, the study outlines pathways for future research on CLIL in LOTE. In practice, the study presents challenges identified by stakeholders to suggest pathways forward in CLIL teaching/learning.Systematic review registrationOpen Science Framework (OSF): https://osf.io/mc9uj.
Dynamic estimates of survival of patients with poorly differentiated thyroid carcinoma: a population-based study
Authors: Liu Zhao , Xu Qianlan , Xia Heng , Wang Miaofeng 
Published: September 2024

BackgroundThe real-time prognostic data of patients with poorly differentiated thyroid carcinoma (PDTC) after surviving for several years was unclear. This study aimed to employ a novel method to dynamically estimate survival for PDTC patients.MethodsA total of 913 patients diagnosed with PDTC between 2014 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database, was recruited in our study. Kaplan–Meier method was used to estimate the overall survival (OS). The conditional survival (CS) outcomes of PDTC were analyzed and CS rates were calculated using the formula CS(y/x) = OS(y+x)/OS(x), whereby CS(y/x) denotes the probability of a patient enduring an additional y years subsequent to surviving x years following the diagnosis of PDTC. The least absolute shrinkage and selection operator (LASSO) regression was employed to identify prognostic predicters and multivariate Cox regression was utilized to develop a CS-nomogram. Finally, the performance of this model was evaluated and validated.ResultsKaplan–Meier survival analysis unveiled patient outcomes demonstrating an OS rate of 83%, 75%, and 60% respectively at the end of 3, 5, and 10 years. The novel CS analysis highlighted a progressive enhancement in survival over time, with the 10-year cumulative survival rate progressively augmenting from its initiation of 60% to 66%, 69%, 73%, 77%, 81%, 83%, 88%, 93%, and finally 97% (after surviving for 1-9 years, respectively) each year. And then 11 (11/15) predictors including age at diagnosis, sex, histology type, SEER stage, T stage, N stage, M stage, tumor size, coexistence with other malignancy, radiotherapy and marital status, were selected by LASSO analysis under the condition of lambda.min. Multivariate Cox regression analysis further highlighted the significant impact of all these predictors on the OS of PDTC and we successfully established and validated a novel CS-nomogram for real-time and dynamic survival prediction.ConclusionsThis was the first study to analyze the CS pattern and demonstrate a gradual improvement in CS over time in long-term PDTC survivors. We then successfully developed and validated a novel CS-nomogram for individualized, dynamic, and real-time survival forecasting, empowering clinicians to adapt and refine the patient-tailored treatment strategy promptly with consideration of evolving risks.
Associations of total protein, albumin, and globulin with insulin resistance: an NHANES study
Authors: Zeng Rui-Xiang , Xu Jun-Peng , Zhang Yu-Zhuo , Tan Jia-Wei , Kong Yong-Jie , Zhang Min-Zhou , Guo Li-Heng 
Published: September 2024

ObjectiveInsulin resistance (IR) is a well-established major risk factor for type 2 diabetes mellitus, nonalcoholic fatty liver disease, and atherosclerotic cardiovascular disease. Previous studies have shown an association between increased serum albumin (ALB) levels and the risk of IR. However, there is a lack of studies simultaneously evaluating the association of total protein (TP), ALB, and globulin (GLB) with IR.MethodsA total of 14,828 individuals (average age 49 ± 18 years) with complete data from the National Health and Nutrition Examination Survey (NHANES) were enrolled and divided into two groups (non-IR group, n = 8,653 and IR group, n = 6,175). Spearman’s correlation analysis, multivariable logistic regression models, restricted cubic spline curves, and subgroup analysis were performed to explore those associations.ResultsAfter adjustment for potential confounders, multivariable logistic regression analysis revealed that scaled per 10g/L increment, the fully adjusted odds ratios (ORs) (95% confidence interval (CI)) for IR prevalence were 1.54 (95% CI 1.41-1.69, P &lt; 0.0001), 1.09 (95% CI 0.95-1.25), P = 0.1995), and 1.62 (95% CI 1.47-1.79, P &lt; 0.0001) for TP, ALB, and GLB respectively. Compared to those in the lowest quantiles, the prevalence of IR in subjects in the highest TP and GLB quantiles was 2.06 and 1.91 times, respectively. Furthermore, restrictive cubic curves confirmed that the relationship of TP, ALB, and GLB with IR prevalence was a linear relationship.ConclusionsThe present cross-sectional study, for the first time, provided supportive evidence of positive associations of TP and GLB with IR, but not ALB, and demonstrated that TP and GLB might be useful markers for IR prevalence.