bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transient Prepubertal Mifepristone Treatment Normalizes Deficits in Contextual Memory and Neuronal Activity of Adult Male Rats Exposed to Maternal Deprivation
Authors: Loi Manila , Sarabdjitsingh Ratna Angela , Tsouli Andromachi , Trinh Stephanie , Arp Marit , Krugers Harmen J. , Karst Henk , van den Bos Ruud , Joëls Marian 
Published: October 2017

AbstractEarly life adversity is a well-known risk factor for behavioral dysfunction later in life, including the formation of contextual memory; it is also (transiently) accompanied by hyperactivity of the stress system. We tested whether mifepristone (MIF) treatment, which among other things blocks glucocorticoid receptors (GRs), during the prepubertal period [postnatal days (PND)26-PND28] normalizes memory deficits in adult male rats exposed to 24-h maternal deprivation (MD) at PND3. MD reduced body weight gain and increased basal corticosterone (CORT) levels during the PND26, but not in adulthood. In adulthood, contextual memory formation of MD compared to noMD (i.e., control) male rats was significantly impaired. This impairment was fully prevented by MIF treatment at PND26-PND28, whereas MIF by itself did not affect behavior. A second behavioral test, a rodent version of the Iowa Gambling Task (rIGT), revealed that flexible spatial learning rather than reward-based aspects of performance was impaired by MD; the deficit was prevented by MIF. Neuronal activity as tested by c-Fos staining in the latter task revealed changes in the right hippocampal-dorsomedial striatal pathway, but not in prefrontal areas involved in reward learning. Follow-up electrophysiological recordings measuring spontaneous glutamate transmission showed reduced frequency of miniature postsynaptic excitatory currents in adult CA1 dorsal hippocampal and enhanced frequency in dorsomedial striatal neurons from MD versus noMD rats, which was not seen in MIF-treated rats. We conclude that transient prepubertal MIF treatment normalizes hippocampus-striatal-dependent contextual memory/spatial learning deficits in male rats exposed to early life adversity, possibly by normalizing glutamatergic transmission.
Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality
Authors: Metzger Michael W. , Walser Sandra M. , Dedic Nina , Aprile-Garcia Fernando , Jakubcakova Vladimira , Adamczyk Marek , Webb Katharine J. , Uhr Manfred , Refojo Damian , Schmidt Mathias V. , Friess Elisabeth , Steiger Axel , Kimura Mayumi , Chen Alon , Holsboer Florian , Arzt Eduardo , Wurst Wolfgang , Deussing Jan M. 
Published: October 2017

A single nucleotide polymorphism substitution from glutamine (Gln, Q) to arginine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated with mood disorders. The P2X7R-Gln460Arg variant per se is not compromised in its function. However, heterologous expression of P2X7R-Gln460Arg together with wild-type P2X7R has recently been demonstrated to impair receptor function. Here we show that this also applies to humanized mice coexpressing both human P2X7R variants. Primary hippocampal cells derived from heterozygous mice showed an attenuated calcium uptake upon agonist stimulation. While humanized mice were unaffected in their behavioral repertoire under basal housing conditions, mice that harbor both P2X7R variants showed alterations in their sleep quality resembling signs of a prodromal disease stage. Also healthy heterozygous human subjects showed mild changes in sleep parameters. These results indicate that heterozygosity for the wild-type P2X7R and its mood disorder-associated variant P2X7R-Gln460Arg represents a genetic risk factor, which is potentially able to convey susceptibility to mood disorders.SIGNIFICANCE STATEMENTDepression and bipolar disorder are the most common mood disorders. The P2X7 receptor (P2X7R) regulates many cellular functions. Its polymorphic variant Gln460Arg has repeatedly been associated with mood disorders. Genetically engineered mice, with human P2X7R, revealed that heterozygous mice (i.e., they coexpress the disease-associated Gln460Arg variant together with its normal version) have impaired receptor function and showed sleep disturbances. Human participants with the heterozygote genotype also had subtle alterations in their sleep profile. Our findings suggest that altered P2X7R function in heterozygote individuals disturbs sleep and might increase the risk for developing mood disorders.
Integrated Flow Processing — Challenges in Continuous Multistep Synthesis
Authors: Pieber Bartholomäus , Gilmore Kerry , Seeberger Peter H. 
Published: October 2017

Abstract
The way organic multistep synthesis is performed is changing due to the adoption of flow chemical techniques, which has enabled the development of improved methods to make complex molecules. The modular nature of the technique provides not only access to target molecules via linear flow approaches but also for the targeting of structural cores with single systems. This perspective article summarizes the state of the art of continuous multistep synthesis and discusses the main challenges and opportunities in this area.
«МОБІКАН » - Б ІЛКОВО - ВІТАМІННО - МІНЕРАЛЬНА ДОБАВКА ДЛЯ ДОМАШНІХ ТВАРИН
Authors: Макаринська А. В. 
Published: October 2017

В матеріалах статті наведені проблеми прояву дисплазії у домашніх тварин (собак) та шляхи її усунення за допомогою введення в раціон білково-вітамінно-мінеральних добавок. Представлені наукові та практичні результати розробки ТУ У 10.9-2574413678-001:2017 Білково-вітамінно-мінеральна добавка для собак “Мобікан”. На основі норм годівлі, хімічних властивостей кормової сировини, біологічних та зоотехнічних досліджень науковообґрунтовані склад та рецептура білково-вітамінно-мінеральної добавки (БВМД) для собак. БВМД для собак “Мобікан” виготовляють згідно затверджених рецептур шляхом дозування та змішування попередньо очищеної і підготовленої білкової сировини тваринного і рослинного походження, мінеральної сировини, пробіотику, преміксу і фітобіотиків (сухих екстрактів рослин). Надано опис та принципову блок-схему виробництва БВМД для собак. Технологічна схема виробництва БВМД для собак включає наступні операції: розтарювання та очистка всіх видів сировини; її подрібнення та гранулометрична підготовка; дозування підготовлених макро- і мікрокомпонентів;дозування і змішування попередньої суміші мікрокомпонентів;основне змішування всіх компонентів або макрокомпонентів з попередньою сумішшю мікрокомпонентів;пакування білково-вітамінно-мінеральної добавки. Наведені технологічні режими процесу змішування у V-подібному змішувачі марки VM-35L: для мікрокомпонентів протягом 120…160 с при частоті обертання робочого органу змішувача n = 1,25…1,4 c-1 ; основне змішування протягом 240…300 с при частоті обертання робочого органу змішувача n = 1,25…1,4 c-1. Представлені дані оцінки якості БВМД для собак за органолептичними, фізико-хімічними, мікробіологічними показниками та показниками безпеки у відповідності з методами контролювання. Гарантійний термін зберігання БВМД для собак «Мобікан» – не більше 2-х місяців з дня виготовлення. Добова норма складає 5 г з розрахунку на 10 кг живої ваги. Виробництво БВМД дозволить розширити асортимент білково-вітамінно-мінеральних добавок для домашніх тварин вітчизняного виробництва та суттєво знизить витрати, оскільки зможе повністю замінити та навіть перевершити кращі закордонні аналоги, допоможе значно зекономити кошти кінологів, бо є значно дешевою.
Presidencia imperial y desequilibrio de poderes en Colombia
Authors: Rodríguez Ortega Julio Armando 
Published: October 2017

Este articulo identifica y caracteriza, el desequilibrio de poderes en Colombia, que ha dado lugar,
a una presidencia imperial, deslegitimadora, del Estado de Derecho, y del mismo sistema jurídico, pues se han desvirtuado de tal forma las garantías constitucionales; que los grandes acontecimientos sociales y políticos están provocando un alto grado de obsolescencia de las instituciones jurídicas y políticas, particularmente de la Democracia en la que más se evidencia la quiebra del esquema originario propuesto para la separación de las ramas del poder público y la nula aplicabilidad la primacía del interés general sobre los intereses particulares. Se requiere por lo tanto la reconstrucción del Estado y de la democracia, para involucrar seriamente la participación de los ciudadanos, más allá de la simple actividad electoral o electorera a fin de que sean los electores y no los elegidos, quienes detenten el poder. Con tal finalidad el Estado debe reconocer la existencia y el protagonismo de las comunidades, abriendo espacios de participación y autorregulación, para que pueda tomar parte efectivamente en las políticas y en las decisiones que los afectan, contribuyendo así a fijar su destino de acuerdo, con las sanas reglas del principio de la subsidiariedad.
La rebelión y el narcotráfico como delitos conexos en el ordenamiento penal colombiano
Authors: Castro Calvache John Jairo 
Published: October 2017

El trabajo revisa desde el punto jurídico penal el tipo delictivo de la rebelión, sin considerar el
ámbito político del mismo, por “…ello el análisis se hará valiéndonos de las categorías propias del ius puniendi.” en el marco del actual debate sobre los delitos que pueden ser objeto de amnistías o indultos para los miembros de la guerrilla que podrían desmovilizarse, la rebelión no ofrece problema alguno para ser objeto de tales medidas, pues su naturaleza y tratamiento histórico lo ubican como delito político.
Nos limitaremos en este análisis a considerar en abstracto si alguien que cometiere delito de narcotráfico con fines políticos podría ser beneficiario de las prebendas propias de los delincuentes políticos.
A study of quality of life among patients undergoing mastectomy for malignant breast lesions
Authors: Shastri Apoorv , Agarwal Manoj , Patel Hardik , Sharma Avantika 
Published: October 2017

Background: To evaluate quality of life of females after mastectomy and factors affecting the same, in various domains of life, and to assess whether a policy of mastectomy is practical or pragmatic in the scenario of low socioeconomic status prevalent in our region.Methods: Two hundred and forty post-operative mastectomized patients were clinically examined and subjected to a questionnaire designed by WHOQOL-BREF along with an ethically cleared questionnaire prepared according to the local prevailing conditions and Quality of Life was evaluated.Results: 52% patients reported no change in body image, only 2% patients reported depression. The total score of the quality of life was good for 40% of the patients with score of 96-130, followed by 55% with moderate 61-95 and only 5% patients with poor with score of <60.Conclusions: In developing countries like India where, there are no proper facilities for advanced haematological and radiological investigations, there is a severe lack of compliance between doctor and patient and there are no facilities for adjuvant and neo-adjuvant treatment, surgeons are forced to choose mastectomy as the surgery of choice for malignant breast lesions.
Prospective randomized study of surgical treatment of pilonidal sinus; primary midline closure after elliptical excision versus rhomboid excision with limberg flap reconstruction versus open excision and healing by secondary intention
Authors: Kumar Rajneesh , Hastir Ankur , Walia Ramandeep S. , Goyal Subhash , Kaur Amandeep 
Published: October 2017

Background: Best surgical treatment of pilonidal sinus is always challenging for a surgeon in term of recurrence. Evaluation of surgical treatment of pilonidal sinus; primary midline closure after elliptical excision versus rhomboid excision with limberg flap reconstruction versus open excision and healing by secondary intention of sacrococcygeal pilonidal disease.Methods: In this prospective randomized study of 75 patients of sacrococcygeal pilonidal sinus were divided into 3 equal groups through randomly assigning the type of surgery. 25 patients of each group. Group I was operated by primary midline closure after elliptical excision, Group II rhomboid excision with limberg flap reconstruction and Group III open excision and healing by secondary intention.Results: Data was assessed between three groups in term of operative time, healing time and recurrence over a follow up period of 1 year. Mean operative time in group I (primary midline closure after elliptical excision) was 38.7±5.1 minutes, group II (Rhomboid excision with Limberg flap reconstruction) was 124.2±5.6 minutes, group III (Open excision and healing by secondary intention) was 20.6±5.6 minutes. Mean healing time for group I was 19.0±7.4 days, for group II was 17.0±8.0 days and for group III was 60±9.6 days. Recurrence occurred in 3 patients in group I and nil in group II and III.Conclusions: Rhomboid excision with limberg flap reconstruction is better choice than primary midline closure after elliptical excision and open excision in terms of healing time and reoccurrence in cases of sacrococcygeal pilonidal sinus.
Intraoperative safety of low pressure pneumoperitoneum cholecystectomy: a comparative study
Authors: Mahajan Salil , Shankar Manu , Garg Vinod K. , Gupta Vijender , Sorout Jaya 
Published: October 2017

Background: With the establishment of laparoscopic cholecystectomy as gold standard for management of cholelithiasis, the current stress is on increasing patient safety. Hence, this study was undertaken to compare the effect of low pressure pneumoperitoneum (LPP <10mm Hg) versus high pressure pneumoperitoneum (HPP >14mm Hg) in a prospective randomized manner on intraoperative safety, assessing the working space and safety by seeing contact of parietal peritoneum to underlying viscera during secondary port insertion.Methods: 120 patients undergoing laparoscopic cholecystectomy were randomized into the LPP (<10mm Hg) group (n=60) and the HPP (>14mm Hg) group (n=60) prospectively. Available working space assessed directly, safety by contact of parietal peritoneum to underlying viscera during secondary port insertion and operative difficulty assessed by visualization, dissection and grasping, total duration of surgery; intra-operative gas consumption, and bile spillage were assessed.Results: There was no significant difference in terms of available working space, operative duration, consumption of carbon dioxide, surgeon’s operative difficulty and intraoperative bile spillage. Out of 180 secondary ports inserted, there was evident contact of 20 (11.1%) secondary ports in high pressure groups and 14 (7.7%) secondary ports in low pressure group, which is suggestive of adequate exposure and working space available for surgery at both pressures.Conclusions: Low-pressure cholecystectomy did not compromise intraoperative safety and should be the standard of care in day care surgery.
Comparison of local versus spinal anesthesia in long standing open inguinal hernia repair
Authors: Goel Anubhav , Bansal Ankur , Singh Akash 
Published: October 2017

Background: Hernias are among the oldest known afflictions of human kind and elective inguinal hernia repair is commonly performed operation in general surgery. General or spinal anesthesia are still the most common types of anesthesia being used in India. Studies comparing the recovery profiles of local, general and regional anesthesia show that local anesthesia is ideal for day care surgery.Methods: This study had included 60 cases of male single sided reducible indirect long standing (more than 5 years) inguinal hernia. Patients were divided randomly into two groups of 30 each named Group A and Group B. Patients in group A were subjected to inguinal hernia mesh repair under local anesthesia and patients in group B were subjected to inguinal hernia mesh repair under spinal anesthesia. Tension free Lichtenstein hernioplasty was done in both groups.Results: Time taken in local anesthesia is higher than spinal anesthesia. Intraoperative pain is higher in local anesthesia than spinal anesthesia. There is no difference on post-operative pain. Post-operative complications are more in spinal anesthesia group.Conclusions: Patient selection is very important and patient with long history should be avoided under local anesthesia.
Excision and primary closure of pilonidal sinus: excellent results
Authors: Singh Arun , Kumar Sujit , Jyoti Vidur , Yadav Preeti , Pandey Akhilesh 
Published: October 2017

Background: Pilonidal sinus (PNS) is an acquired condition described as a chronic sinus containing hairs and found between the buttocks. Best surgical method is still being searched for treatment of PNS in terms of minimizing disease recurrence and patient discomfort.Methods: The prospective study of 40 patient undergoing excision and primary closure of pilonidal sinus from October 2013 to July 2016 at Max Super Speciality Hospital Gurgaon.Results: Mean operative time was 30 minutes. One patient developed hematoma due to blockage of drain on post-operative day 2 which was flushed with saline and drain made patent, one patient developed seroma and one had wound infection. Rest other patients had uneventful course post operatively. No recurrence was noted over 6 month follow up.Conclusions: We advocate this method of treating PNS which is simple, less time consuming, short hospital stay, rapid healing, shorter time off work, minimal recurrence with excellent results.
Fine needle aspiration cytology versus trucut biopsy in the diagnosis of breast cancer: a comparative study
Authors: A. Shashirekha C. , R. Rahul Singh , R. Ravikiran H. , N. Sreeramulu P. , Prasad Krishna 
Published: October 2017

Background: Most diseases of the breast present as a palpable mass. The majority of breast lesions are not malignant, and most benign lesions do not progress to cancer; however, the accuracy of diagnosis can be increased by a combination of preoperative tests like physical examination, mammography, fine-needle aspiration cytology (FNAC), and Trucut needle biopsy (TGNB) or core needle biopsy (CNB). FNAC has grown in popularity and became the first initial used procedure after history taking and clinical examination for diagnosis of solid and cystic breast lumps. This study was designated to investigate the accuracy of FNAC in comparison to TCNB for diagnosis of breast masses, Design: Retrospective Study.Methods: In this study, 62 patients having breast lumps were studied during the period from January 2014 to January 2017 in terms of FNAC and Trucut Biopsy and were compared with tissue diagnosis. Variables like age, marital status, duration, size, menstrual status and site were analyzed using statistical analysis.Results: Out of 62 patients with breast lump, 32 were diagnosed with Benign Breast lesions, and 30 with malignant lesions. Sensitivity of FNAC and TRUCUT biopsy were 84.34% and 97.1% respectively. TRUCUT was more accurate when compared to FNAC.Conclusions: Both FNAC and Core Needle Biopsy are complimentary to each other and are useful in diagnosis of breast lesions.
Surgical management of post corrosive acid ingestion symptomatic gastric outlet obstruction: single institute experience in 81 patients
Authors: Shetty Sushruth , Desai Premal R. , Bhavsar Mahendra S. , Vora Hasmukh B. , Khiria Laxman S. , Jillawar Nikhil , Yadav Ajay Kumar 
Published: October 2017

Background: Corrosive injury resulting in gastric outlet obstruction (GOO) is fairly uncommon in world literature. We aim to study the socio-demographic variables of corrosive acid ingestion patients presenting as symptomatic GOO, along with the surgical procedure performed in these patients, post-operative complications and long term follow up data.Methods: We included all patients with clinical features of gastric outlet obstruction following acid ingestion, who were operated in our department between January 2006 and April 2017. We collected patient’s demographic data, parameters during surgery, body weight and nutritional status pre- and post-operatively, which were all derived from case records and outpatient records. Follow up data of the patient were collected when possible.Results: During the study period, 81 patients were enrolled in the study; 42 males, average age 35.76±3.53 years, 82% had suicidal intent of ingestion and 18% accidental; average follow-up period was 80.5 months. After an average period of 6 months, 94% underwent loop gastrojejunostomy. Approximately, 22% suffered complications like surgical site infections, postoperative fever, pulmonary infections and postoperative vomiting. Average follow up of 6.7 years done in 68 patients who underwent only bypass without resection, none of the patients developed any malignancy of upper gastrointestinal tract.Conclusions: Staged treatment for GOO patients was seen to be associated with good clinical outcomes and few complications. Bypass of cicatrised stomach without resection gives acceptable results.
Shifting Paradigm of Modern Islam Fundamentalism as Islamized Space Autonomy in Indonesia
Authors: Ariwidodo Eko 
Published: October 2017

Idealism various groups of political Islam failed to change the political landscape of the Middle East and some other regions. Political Islam is not won power, while the old regimes are still in power. Western powers are increasingly plugging hegemony (political, economic, cultural) in the region. Political Islam is also not always successfully display the values contained in the ideals of fundamentalism in the form of the application of religious laws in politics. Islamic fundamentalists in some places only produce changes that are not significant in the fields of law, politics and economics. In this case, fundamentalism does emphasize the application of Sharia totally, but often do not care about the character of the political system. The variant of the traditional and modern fundamentalism fundamentalism can be seen also shift to the neo-fundamentalism. Orientation and strategy of neo-fundamentalism is the master of society through social action, far from being revolutionary, neo-fundamentalists are now entering into civil society and political classes. Although the character of the revolution is lost, the symbols of Islam seeped into the public and political discourse of Islam. Neo-fundamentalism seeks re-islamization society at grassroots level, and no longer through the country. Fundamentalists are directing the struggle in the birth of an Islamic society and Islamic space. This shift has seen as a symbol of Islamic fundamentalism in the political failure that resulted in a significant change in the weight of thought and movement.Copyright (c) 2017 by KARSA. All right reserved DOI: 10.19105/karsa.v25i1.1357
“CONSUMO DE ALIMENTOS RESTRINGIDOS” EN PACIENTES HIPERTENSOS MEXICANOS: UN ANÁLISIS DE TRAYECTORIA
Authors: Piña López Julio Alfonso 
Published: October 2017

Introducción: La adhesión estricta a las recomendaciones del personal de salud es requisito indispensable para coadyuvar en el control clínico de la hipertensión arterial[W1] .Objetivo: Identificar los predictores de la conducta “consumo de alimentos restringidos” en una muestra de pacientes hipertensos de Tamaulipas, México.Método: Participaron 183 pacientes diagnosticados con hipertensión arterial, quienes respondieron a un par de instrumentos y a diferentes preguntas sobre conductas de adhesión y cuidado de la salud. Para la interpretación de los datos se utilizó un análisis de trayectoria.Resultados: Una menor tolerancia a la frustración, un mayor apoyo social afectivo y un menor índice de masa corporal predijeron la conducta de evitar el “consumo de alimentos restringidos” (pBS = .294, χ2/gl = 1.417, GFI = .993, AGFI = .965, NFI = .934, IFI = .980 y SRMR = .040), explicando aproximadamente un 20% de la varianza en la conducta de estudio.Conclusión: El estudio de las conductas de adhesión y cuidado de la salud pasa necesariamente por identificar qué y cómo ciertas variables personales e interpersonales están influyendo en su práctica diaria, lo cual puede contribuir a mejorar los programas de intervención interdisciplinaria en los ámbitos clínico y comunitario para la atención de pacientes que viven con hipertensión arterial. [W1]Se añadió el término arterial y se hizo lo propio en todo el texto.