bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Catalytic Arylsulfonyl Radical Triggered 1,7‐Enyne Bicyclizations.
Authors: Zhu Yi‐Long , Jiang Bo , Hao Wen‐Juan , Qiu Jiang‐Kai , Sun Jun , Wang De‐Cai , Wei Ping , Wang Ai‐Fang , Li Guigen , Tu Shu‐Jiang 
Published: April 2016

AbstractA novel metal‐free bicyclization reaction of 1,7‐enynes (I) anchored by α,β‐conjugates with arylsulfonyl radicals generated in situ from sulfonyl hydrazides is established.
ChemInform Abstract: Intramolecular Conjugate Additions with Heterocyclic Olefins.
Authors: Boblak Kenneth N. , Gasonoo Makafui , Zhang Yiliang , Klumpp Douglas A. 
Published: April 2016

AbstractOlefinic substrates bearing different N‐heterocyclic ring systems are subjected to a triflic acid mediated title reaction to produce the addition products shown.
ChemInform Abstract: Synthesis of 3‐Thia‐1‐dethiacephems via Regioselective Iodocyclization Reaction.
Authors: Garud Dinesh R. , Rode Navnath D. , Bathe Sagar R. , Ranpise Vinod S. , Joshi Ramesh A. , Joshi Rohini R. , Koketsu Mamoru 
Published: April 2016

AbstractA variety of bicyclic β‐lactams are obtained by regioselective iodocyclization of substituted propargylazetidine‐carbothioamides.
ChemInform Abstract: Cobalt Catalyzed C—H and N—H Bond Annulation of Sulfonamide with Terminal and Internal Alkynes.
Authors: Kalsi Deepti , Sundararaju Basker 
Published: April 2016

AbstractAn efficient procedure is elaborated for the Co‐catalyzed oxidative annulation of sulfonamides with alkynes leading to benzothiazine derivatives with high regioselectivity and excellent functional group tolerance.
ChemInform Abstract: A Protocol for the exo‐Mono and exo,exo‐Bis Functionalization of the Diazocine Ring of Troeger′s Base.
Authors: Dawaigher Sami , Maansson Kristoffer , Ascic Erhad , Artacho Josep , Maartensson Roger , Loganathan Nagarajan , Wendt Ola F. , Harmata Michael , Snieckus Victor , Waernmark Kenneth 
Published: April 2016

AbstractThe direct addition method presented renders possible the access to the desired product types (III) and (IV).
ChemInform Abstract: β‐Ketophosphonates Formation via Deesterification or Deamidation of Cinnamyl/Alkynyl Carboxylates or Amides with H‐Phosphonates.
Authors: Zhou Yao , Zhou Mingxin , Chen Ming , Su Jihu , Du Jiangfeng , Song Qiuling 
Published: April 2016

AbstractThe convenient copper/iron‐catalyzed aerobic oxyphosphorylation method allows the conversion of a wide range of esters and amides into β‐ketophosphonates.
ChemInform Abstract: Microwave‐Assisted Synthesis of Dialkylphosphinic Acids and a Structure—Reactivity Study in Rare Earth Metal Extraction.
Authors: Du Ruo‐Bing , An Huaying , Zhang Suhui , Yu Donghai , Xiao Ji‐Chang 
Published: April 2016

AbstractDialkylphosphinic acids are prepared by microwave assisted reaction of α‐olefins with sodium hypophosphite.
ChemInform Abstract: Hypercoordinate Compounds of the Group 14 Elements Containing ϰn‐C,N‐, C,O‐, C,S‐ and C,P‐Ligands
Authors: Khan Aman , Foucher Daniel 
Published: April 2016

AbstractReview: syntheses as well as investigations of their unique structures and electronic roperties; 115 refs.
ChemInform Abstract: Advances in the Domain of 4‐Amino‐3‐mercapto‐1,2,4‐triazine‐5‐ones
Authors: Hamama Wafaa S. , El‐Bana Ghada G. , Shaaban Saad , Habib O. M. O. , Zoorob Hanafi H. 
Published: April 2016

AbstractReview: [synthesis and reactions of 4‐amino‐3mercapto‐1,2,4‐triazine‐5‐ones reported from 1983 to mid.
ChemInform Abstract: Singlet Oxygen and Natural Substrates: Functional Polyunsaturated Models for the Photooxidative Degradation of Carotenoids
Authors: Griesbeck Axel G. , Kleczka Margarethe , de Kiff Alan , Vollmer Moritz , Eske Angelika , Sillner Sarah 
Published: April 2016

AbstractReview: 65 refs.
Synthesis and Evaluation of Glycoconjugates Comprising N‐Acyl‐Modified Thomsen–Friedenreich Antigens as Anticancer Vaccines
Authors: Sun Shuang , Zheng Xiu‐Jing , Huo Chang‐Xin , Song Chengcheng , Li Qin , Ye Xin‐Shan 
Published: April 2016

AbstractThomsen–Friedenreich (TF) antigen is an important tumor‐associated carbohydrate antigen. Its low immunogenicity, however, limits its application in the development of anticancer vaccines. To solve this problem, several N‐acyl‐modified TF derivatives were synthesized and conjugated with carrier protein CRM197 (a mutated diphtheria toxoid cross‐reactive material). The immunological results in BALB/c mice demonstrated that these modified TF antigen conjugates could stimulate the production of higher titers of IgG antibodies that cross‐reacted with native TF antigen. These glycoconjugates showed strong lymphocyte proliferative response, suggesting that they can induce cellular immunity. Furthermore, the elicited antisera reacted strongly with TF‐positive tumor cells (4T1). In particular, the N‐monofluoroacetyl‐modified TF conjugate 4‐CRM197 showed the strongest complement‐dependent cytotoxicity effect against 4T1 cells, implying the potential of this glycoconjugate as an anticancer vaccine.
How Veterans Health Administration Suicide Prevention Coordinators Assess Suicide Risk
Authors: Pease James L. , Forster Jeri E. , Davidson Collin L. , Holliman Brooke Dorsey , Genco Emma , Brenner Lisa A. 
Published: April 2016

This cross‐sectional study was designed to examine the suicide risk assessment practices of Suicide Prevention Coordinators (SPCs) within the Veterans Health Administration. Specifically, this study sought to (1) identify factors SPCs consider most important in assessing risk and patient priority; (2) measure the level of consistency and agreement between SPCs in assessing suicide risk and prioritizing cases; and (3) measure individual SPC consistency between cases. SPCs (n = 63) responded to online survey questions about imminent and prolonged risk for suicide in response to 30 fictional vignettes. Combinations of 12 acute and chronic suicide risk factors were systematically distributed throughout the 30 vignettes using the Fedorov () procedure. The SPCs were also asked to identify the level of priority for further assessment both disregarding and assuming current caseloads. Data were analysed using clinical judgement analysis. Suicidal plan, β = 1.64; 95% CI (1.45, 1.82), and preparatory behaviour, β = 1.40; 95% CI (1.23, 1.57), were considered the most important acute or imminent risk factors by the SPCs. There was less variability across clinicians in the assessment of risk when alcohol use (p = 0.02) and hopelessness (p = 0.03) were present. When considering acute or imminent risk factors, there was considerable variability between clinicians on a vignette‐by‐vignette basis, median SD = 0.86 (range = 0.47, 1.13), and within individual clinicians across vignettes, median R2 = 0.80 (0.49, 0.95). These findings provide insight into how this group of providers think about acute and chronic risk factors contributing to imminent suicide risk in Veterans. Copyright © 2016 John Wiley & Sons, Ltd.Key Practitioner Message

Identifies factors that practitioners consider most important in suicide risk assessment
Discusses how to distinguish between chronic and acute risk for suicide
Identifies factors that lead to more consistent clinical judgments
In Situ Radiographic Investigation of (De)Lithiation Mechanisms in a Tin‐Electrode Lithium‐Ion Battery
Authors: Sun Fu , Markötter Henning , Zhou Dong , Alrwashdeh Saad Sabe Sulaiman , Hilger Andre , Kardjilov Nikolay , Manke Ingo , Banhart John 
Published: April 2016

AbstractThe lithiation and delithiation mechanisms of multiple‐Sn particles in a customized flat radiography cell were investigated by in situ synchrotron radiography. For the first time, four (de)lithiation phenomena in a Sn‐electrode battery system are highlighted: 1) the (de)lithiation behavior varies between different Sn particles, 2) the time required to lithiate individual Sn particles is markedly different from the time needed to discharge the complete battery, 3) electrochemical deactivation of originally electrochemically active particles is reported, and 4) a change of electrochemical behavior of individual particles during cycling is found and explained by dynamic changes of (de)lithiation pathways amongst particles within the electrode. These unexpected findings fundamentaly expand the understanding of the underlying (de)lithiation mechanisms inside commercial lithium‐ion batteries (LIBs) and would open new design principles for high‐performance next‐generation LIBs.
A New Molecularly Imprinted Polymer (MIP)‐based Electrochemical Sensor for Monitoring Cardiac Troponin I (cTnI) in the Serum
Authors: Zuo Juanjuan , Zhao Xiaoyu , Ju Xiaocui , Qiu Shue , Hu Wenshuai , Fan Ting , Zhang Juankun 
Published: April 2016

AbstractA novel molecularly imprinted polymer (MIP) sensor for rapid determination of cardiac troponin (cTnI) was established. Since it can bind to the template molecule cTnI specifically, it can be used to detect concentration of cTnI in serum without much sample pretreatment. What's more, the electrochemical signals depend on the concentration of template molecules. The synthetic sensor possesses advantages including simplicity, high specificity, low cost of preparation, good chemical and mechanical properties, sensitive and label‐free determination. The synthetic sensor shows good dynamic linearity at concentration range from 0.05 to 5.00 nM. The limit of detection (LOD) was found to be 0.027 nM. The detection time of whole process was within 5 minutes.
Evaluation of Netrin‐1 Levels and Albuminuria in Patients With Diabetes
Authors: Ay Emre , Marakoğlu Kamile , Kizmaz Muhammet , Ünlü Ali 
Published: April 2016

BackgroundNetrin‐1 is a diagnostic biomarker that has been identified recently for chronic renal failure (CRF) in animal experiments. Netrin‐1 levels in urine have been shown to have increased significantly at the acute kidney damage. Human studies on the relation between the CRF and plasma netrin‐1 levels have not been found in the literature. This study aimed to investigate whether plasma netrin‐1 levels increased in the early stages of the CRF in diabetic patients.MethodsPlasma samples from healthy volunteers and diabetic patients with and without microalbuminuria were collected after receiving consent. Netrin‐1 in plasma was quantified by enzyme‐linked immunosorbent assay and the data were analyzed to determine whether plasma netrin‐1 correlates significantly with disease progression.ResultPlasma netrin‐1 level in microalbuminuric diabetic patients was significantly higher than in normoalbuminuric diabetic patients and the control group. However, no significant difference between normoalbuminuric patients and control group was determined. Plasma netrin‐1 level was significantly associated with albuminuria and estimated glomerular filtration rate, independently of age and sex.ConclusionThis study supports that plasma netrin‐1 level increases significantly when glomerular damage occurs in diabetic nephropathy.
Higher Pentraxin‐3 Levels are Associated With Inflammation in Familial Mediterranean Fever
Authors: Bulut Mesudiye , Ceri Mevlut , Unverdi Selman , Altay Mustafa , Senes Mehmet , Ecemis Zafer Aydın , Duranay Murat 
Published: April 2016

BackgroundCirculating levels of Pentraxin‐3 (PTX3) have been shown to increase in several inflammatory conditions. However, there is no information about the levels of PTX3 in patients with familial Mediterranean fever (FMF). This study was designed to evaluate the serum PTX3 levels in patients with FMF during attack and free‐attack periods.MethodsTwenty FMF patients in attack and free‐attack period, and 20 age‐, sex‐, and body mass index‐matched healthy controls were included in the study. Blood samples were obtained within the first 24 h of the attack period and between attacks, and levels of white blood cell, erythrocyte sedimentation rate, Fibrinogen, high sensitive CRP, and PTX3 were determined.ResultsPTX3 levels during the attack period were not significantly different from those in free‐attack patients (4.9 ± 4.6 ng/ml vs. 2.8 ± 1.4 ng/ml, P > 0.05). However, both attack and free‐attack patients had significantly higher PTX3 levels than healthy controls (4.9 ± 4.6 ng/ml vs. 1.8 ± 0.8 ng/ml, P < 0.001; 2.8 ± 1.4 ng/ml vs. 1.8 ± 0.8 ng/ml, P < 0.025, respectively).ConclusionsPTX3 levels were not markedly affected from FMF attacks, but high level of PTX3 in free‐attack period of FMF patients shows ongoing subclinical inflammation. However, further studies are needed to determine its usefulness as a marker in clinical practice.
Single Lysis‐Salting Out Method of Genomic DNA Extraction From Dried Blood Spots
Authors: Shaik Muntaj , Shivanna Devaraju Kuramkote , Kamate Mahesh , AB Vedamurthy , TP Kruthika‐Vinod 
Published: April 2016

BackgroundDried blood spots (DBS) are an important form of bio‐sampling and valuable approach for storing blood samples for genetic studies. This has necessitated in developing an effective protocol to isolate genomic DNA (gDNA) from DBS samples.In this study, we have elucidated a dependable and non‐hazardous “single lysis‐salting out” (SLSO) protocol of gDNA extraction from DBS and compared against the available commercial kits.MethodsFor the purpose of this study, blood spots were collected on S&S 903 filter cards from 10 healthy volunteers and 30 patients with glutaric aciduria type I (GA‐I). The gDNA was extracted from theseDBS samples by SLSO, QIAamp® gDNA Micro kit and innuPREP forensic kit methods. The quantity and quality of gDNA obtained from these methods were determined by measuring the absorbance using a Nanodrop spectrophotometer.ResultsThe SLSO method showed four‐fold and eight‐fold increased yield of gDNA in healthy volunteers and patient samples, respectively, compared to commercial kits (p<0.0001). The protocol was also found to be cost efficient, reducing the per sample cost to almost half. The suitability of this method for genetic studies was confirmed by performing R402W genotyping by RFLP in GA‐I patients. The genotyping results showed the presence of R402W mutation in 20% (6/30) of patients.ConclusionThe SLSO method was found to be inexpensive, non‐hazardous and a suitable technique for isolating gDNA from DBS samples for genetic studies.
Adipose stromal cells improve healing of vocal fold scar: Morphological and functional evidences
Authors: de Bonnecaze Guillaume , Chaput Benoit , Woisard Virginie , Uro‐Coste Emmanuelle , Swider Pascal , Vergez Sebastien , Serrano Elie , Casteilla Louis , Planat‐Benard Valerie 
Published: April 2016

Objectives/HypothesisAdipose derived stromal cells (ASCs) are abundant and easy to prepare. Such cells may be useful for treating severe vocal disturbance caused by acute vocal fold scars.Study DesignProspective animal experiments with controls.MethodsTwenty New‐Zealand white rabbits were used in the present study. We evaluated vocal fold healing, with or without injection of autologous ASCs, after acute scarring. A defined lesion was created and the ASCs were immediately injected. Vocal fold regeneration was evaluated histomorphometrically and via viscoelastic analysis using an electrodynamic shaker.ResultsSix weeks after ASC injection, vocal folds exhibited significantly less inflammation than control folds (P < 0.005). In addition, hypertrophy of the lamina propria and fibrosis were significantly reduced upon ASC injection (P < 0.02). The decrease in viscoelastic parameters was less important in the ASC injected group compared to the noninjected group (P = 0.08).ConclusionInjection of autologous ASCs improved vocal fold healing in our preclinical model. Further studies are needed, but this method may be useful in humans.Level of EvidenceNA. Laryngoscope, 126:E278–E285, 2016
Antibiotic prescription for acute rhinosinusitis: Emergency departments versus primary care providers
Authors: Bergmark Regan W. , Sedaghat Ahmad R. 
Published: April 2016

Objectives/HypothesisWe have previously identified patient characteristics associated with emergency department (ED) rather than primary‐care provider (PCP) presentation for uncomplicated acute rhinosinusitis (ARS). Here we investigate potential disparities in prescription of antibiotics for patients presenting to a PCP versus ED for uncomplicated ARS.Study DesignCross‐sectional study of the 2005 to 2010 National Ambulatory Medical Care Surveys and National Hospital Ambulatory Medical Care Surveys.MethodsA total of 37,975,715 patient presentations for uncomplicated ARS to PCPs and EDs. The primary outcome measure was prescription of an oral antibiotic, which was tested for association with clinical setting (PCP vs. ED) and clinical, demographic, and socioeconomic patient characteristics.ResultsAmong adult ARS presentations, 57.0% received an antibiotic prescription from a PCP versus 59.1% in the ED. Pediatric patients also were commonly prescribed antibiotics by PCPs (52.9%) and EDs (51.4%). Compared to PCPs, EDs were not associated with antibiotic prescription for adults (odds ratio [OR] = 1.09, 95% confidence interval [CI]: 0.79–1.50, P = 0.613) or children (OR = 0.94, 95% CI: 0.51–1.72, P = 0.840). Among PCP visits, antibiotic prescription was more likely in the Northeast United States (OR = 2.90, 95% CI: .31–6.38, P = 0.009). No other demographic, clinical, or socioeconomic patient characteristics, including insurance status, were associated with antibiotic prescription by PCPs or EDs.ConclusionMore than half of ARS patients presenting to PCPs and EDs are prescribed antibiotics. There was no differential antibiotic prescription for ED versus PCP presentation. ARS patients in the Northeast were more likely to receive antibiotics from PCPs, whereas no such variation was seen for EDs. Interventions targeting PCPs, especially in the Northeast, may reduce excessive antibiotic utilization.Level of Evidence4. Laryngoscope, 126:2439–2444, 2016
Effect of low frequency on speech performance with bimodal hearing in bilateral severe hearing loss
Authors: Choi Seong Jun , Lee Jong Bin , Bahng Junghwa , Lee Won Ki , Park Chan Hum , Kim Hyung‐Jong , Lee Jun Ho 
Published: April 2016

Objectives/HypothesisUnilateral cochlear implantation has emerged as a widely accepted procedure to treat severe to profound hearing loss, but many studies have reported benefits in terms of speech comprehension when listeners with residual low‐frequency hearing in the nonimplanted ear use a hearing aid.Study DesignRetrospective study.MethodsIn this study, we analyzed the speech performance and satisfaction of bimodal hearing according to the residual low‐frequency hearing level in the nonimplanted ear. Based on low‐frequency pure‐tone audiometry (average of 250 Hz and 500 Hz) in the nonimplanted ear, we classified individuals into three groups as follows: group A (under 70 dB), group B (71–90 dB), and group C (over 91 dB). Listeners were tested using the Word Recognition Score, the Korea‐Central Institute for Deaf sentence recognition test, and the Korean version of the Hearing Handicap Inventory for the Elderly questionnaire.ResultsWe observed a bimodal benefit when the residual low‐frequency threshold was less than 70 dB HL and a greater satisfaction with bimodal hearing compared to cochlear implant alone, when the residual low‐frequency threshold was less than 70 dB HL.ConclusionsThis study supports the benefits of bimodal hearing in listeners with bilateral severe to profound sensorineural hearing loss as standard clinical practice, when the residual low‐frequency hearing threshold is under 70 dB in the nonimplanted ear.Level of Evidence4 Laryngoscope, 126:2817–2822, 2016
Temperature‐dependent phase‐segregation behavior and antifouling performance of UV‐curable methacrylated PDMS/PEG coatings
Authors: Gu Yunjiao , Zhou Shuxue , Luo Huali , Wu Limin , Gao Wei , Yang Jinlong 
Published: April 2016

ABSTRACTControllable phase segregation adjustment for immiscible polymer blends has always been tough, which hinders the development of amphiphilic antifouling coatings from more accessible blends. Herein, methacrylated poly(dimethylsiloxane) (PDMS‐MA) was synthesized and mixed with poly(ethylene glycol)methylether methacrylate (PEG‐MA). It was interestingly discovered that these PDMS‐MA/PEG‐MA blends displayed upper critical solution temperatures (UCST) due to thermo‐induced conformational change of PEG‐MA and the UCST changed with PDMS‐MA/PEG‐MA mass ratios. Micro‐/nano‐phase segregation, nanophase segregation, or homogenous morphology were therefore achieved. These PDMS‐MA/PEG‐MA blends with different mass ratios were UV‐cured under varying temperatures to fabricate coatings. Their surface morphology and wettability are readily adjusted by phase segregation. For the first time, highly hydrophilic surface was achieved for coatings with microphase segregation because of the exposure of PEG‐rich domains, which exhibited an enhanced protein resistance against bovine serum albumin (BSA). Anti‐bacterial performance (Shewanella loihica) was also observed for these PDMS/PEG coatings. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 1612–1623
Do Healthcare Professionals Comprehend Standardized Symbols Present on Medical Device Packaging?: An Important Factor in the Fight Over Label Space
Authors: Seo Do Chan , Ladoni Moslem , Brunk Eric , Becker Mark W. , Bix Laura 
Published: April 2016

Objective: Evaluate the ability of healthcare providers from the US to comprehend internationally standardized symbols placed on medical device packaging. Participants: Eighty‐six healthcare providers attending the Association of Surgical Technologists (AST) Instructors' Forum (Savannah, GA February 2014), the 46th Annual AST National Conference (Denver, CO May 2014), or members of the same organization that responded to a targeted email blast. Measures: We adapted the comprehension portion of ISO 9186‐1: 2007 to test 38 standardized symbols developed for the medical device industry. Participants were asked to provide an open‐ended response regarding the meaning of each symbol. Survey responses were categorized into five levels of comprehension: correct, wrong, opposite, don't know or no response. Symbols receiving response rates of ≥85% in the correct category were considered successful. Conversely, if responses categorized as opposite were ≥5%, symbols were considered ‘critically confusing.’ Main Results: Six of 38 symbols were classified as ‘successful’; five of the six had text (in English) imbedded within. Three out of the 38 were categorized as ‘critically confusing’; they were not only misunderstood, but, in fact, interpreted to mean the opposite of what was intended by ≥5% of participants surveyed. Conclusions: Given that the medical device industry in the US has requested permission from the US Food and Drug Administration (FDA) to use stand‐alone symbols to better harmonize with EU Directives, the exploration of healthcare providers' comprehension of the same is an important and timely topic. Our work suggests that symbols commonly incorporated into the labeling of medical devices may not be readily understood at present. As such, policy decisions should be carefully considered. Limitations: Although we provided participants with a general context of use (i.e. these symbols are used on medical devices), the specific part of the hospital, or type of procedure where the symbol would be found was not noted. Further research to evaluate symbol comprehension with specific context (e.g. IVD, general procedure, etc.) is recommended.Run order was presented consistently throughout the experiment in the same booklet. We tested whether or not this impacted results in two ways: (a) by correlating run order with mean performance to see if there was a trend through the data (toward improvement or decline) and (b) by assuming repeated measures from subjects to test if the subject response changes with time. Neither of these analyses suggested significant effects because of run order. Copyright © 2016 John Wiley & Sons, Ltd.