bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘This Is My Truth, Now Tell Me Yours’: Emphasizing dialogue within Participatory Music
Authors: Camlin David A. 
Published: December 2015

Abstract
As a group, musicians have traditionally been resistant to conceptualizing their educational practice in participatory settings. Rather than continuing to strive for an elusive consensus, this article suggests we would do better to see our work in a different way, using the concept of dialogue to enable all of the diverse perspectives on music educational practice to have validity, as well as giving us insights into the kinds of teaching and learning exchanges that go on in Participatory Music. In particular, the concept of dialogue invites us to re-appraise some of the traditional dichotomies associated with music and music education – e.g. access/excellence, process/product, ethical/technical – so that they too can be seen as positions that ‘widen dialogic space’.
The impacts of a community orchestra in a rural setting: An insight into Borderland Community Orchestra
Authors: Darby Shannon 
Published: December 2015

Abstract
This article investigates the cultural impacts of a community orchestra in a rural setting through the examination of ‘Borderland Community Orchestra’, a crossborder ensemble operating in northern Ontario, Canada and northern Minnesota, United States. In May 2013, two surveys were conducted to understand how members of the orchestra and other community residents perceived the ensemble’s role in the rural arts culture of the area. The themes that emerged include the enrichment of local arts, importance of word-of-mouth communication and sense of community. Throughout the article, survey findings are reinforced by modern literature to demonstrate the necessity of community ensembles in the development of rural arts and the challenges of achieving sustainability. Survey responses are collected into three recommendations, which will assist Borderland Community Orchestra and other ensembles to more effectively connect with their communities: (1) Better marketing and increased awareness; (2) Perform more concerts; (3) Youth outreach and involvement. The conclusions illustrate the power of community musicmaking and deepen the understanding of community orchestras operating in rural areas around the world.
‘Montreal might eat its young, but Montreal won’t break us down’: The co-production of place, space and independent music in Mile End, 1995–2015
Authors: Bedford William 
Published: December 2015

Abstract
This article seeks to link the processes of gentrification in Montreal’s Mile End neighbourhood with its musical history over the past twenty years. A selective chronology of independent music from the neighbourhood is described, beginning with the early years of instrumental rock group Godspeed You Black Emperor! and concluding with the recent output of electronic music label Arbutus Records, via the commercial breakthrough of Arcade Fire’s Funeral album in 2004. Through a discussion of the ideas of Henri Lefebvre, Sharon Zukin and David Ley’s interpretation of the theories of Pierre Bourdieu, it is argued that the music produced in the neighbourhood can be seen as unified with its physical spaces in a number of ways under contemporary capitalism; in their parallel trajectories of progression and renewal and in the way they both construct and are constructed by notions of ‘place’. While it is argued that the dynamism of the music scene in Mile End has been intimately connected to broader processes of urban economic restructuring, the article also highlights the challenges an increasingly gentrified Mile End faces in maintaining its status as a fertile centre of cultural production.
Dissociating Value Representation and Inhibition of Inappropriate Affective Response during Reversal Learning in the Ventromedial Prefrontal Cortex
Authors: Zhang (张之昊) Zhihao , Mendelsohn Avi , Manson Kirk F. , Schiller Daniela , Levy Ifat 
Published: December 2015

AbstractDecision-making studies have implicated the ventromedial prefrontal cortex (vmPFC) in tracking the value of rewards and punishments. At the same time, fear-learning studies have pointed to a role of the same area in updating previously learned cue–outcome associations. To disentangle these accounts, we used a reward reversal-learning paradigm in a functional magnetic resonance imaging study in 18 human participants. Participants first learned that one of two colored squares (color A) was associated with monetary reward, whereas the other (color B) was not, and then had to learn that these contingencies reversed. Consistent with value representation, activity of a dorsal region of vmPFC was positively correlated with reward magnitude. Conversely, a more ventral region of vmPFC responded more to color A than to color B after contingency reversal, compatible with a role of inhibiting the previously learned response that was no longer appropriate. Moreover, the response strength was correlated with subjects’ behavioral learning strength. Our findings provide direct evidence for the spatial dissociation of value representation and affective response inhibition in the vmPFC.
Stage-Specific Plasticity in Ovary Size Is Regulated by Insulin/Insulin-Like Growth Factor and Ecdysone Signaling in Drosophila
Authors: Mendes Cláudia C , Mirth Christen K 
Published: December 2015

Abstract
Animals from flies to humans adjust their development in response to environmental conditions through a series of developmental checkpoints, which alter the sensitivity of organs to environmental perturbation. Despite their importance, we know little about the molecular mechanisms through which this change in sensitivity occurs. Here we identify two phases of sensitivity to larval nutrition that contribute to plasticity in ovariole number, an important determinant of fecundity, in Drosophila melanogaster. These two phases of sensitivity are separated by the developmental checkpoint called “critical weight”; poor nutrition has greater effects on ovariole number in larvae before critical weight than after. We find that this switch in sensitivity results from distinct developmental processes. In precritical weight larvae, poor nutrition delays the onset of terminal filament cell differentiation, the starting point for ovariole development, and strongly suppresses the rate of terminal filament addition and the rate of increase in ovary volume. Conversely, in postcritical weight larvae, poor nutrition affects only the rate of increase in ovary volume. Our results further indicate that two hormonal pathways, the insulin/insulin-like growth factor and the ecdysone-signaling pathways, modulate the timing and rates of all three developmental processes. The change in sensitivity in the ovary results from changes in the relative contribution of each pathway to the rates of terminal filament addition and increase in ovary volume before and after critical weight. Our work deepens our understanding of how hormones act to modify the sensitivity of organs to environmental conditions, thereby affecting their plasticity.
The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans
Authors: Grants Jennifer M , Ying Lisa T L , Yoda Akinori , You Charlotte C , Okano Hideyuki , Sawa Hitoshi , Taubert Stefan 
Published: December 2015

Abstract
Cell signaling pathways that control proliferation and determine cell fates are tightly regulated to prevent developmental anomalies and cancer. Transcription factors and coregulators are important effectors of signaling pathway output, as they regulate downstream gene programs. In Caenorhabditis elegans, several subunits of the Mediator transcriptional coregulator complex promote or inhibit vulva development, but pertinent mechanisms are poorly defined. Here, we show that Mediator’s dissociable cyclin dependent kinase 8 (CDK8) module (CKM), consisting of cdk-8, cic-1/Cyclin C, mdt-12/dpy-22, and mdt-13/let-19, is required to inhibit ectopic vulval cell fates downstream of the epidermal growth factor receptor (EGFR)-Ras-extracellular signal-regulated kinase (ERK) pathway. cdk-8 inhibits ectopic vulva formation by acting downstream of mpk-1/ERK, cell autonomously in vulval cells, and in a kinase-dependent manner. We also provide evidence that the CKM acts as a corepressor for the Ets-family transcription factor LIN-1, as cdk-8 promotes transcriptional repression by LIN-1. In addition, we find that CKM mutation alters Mediator subunit requirements in vulva development: the mdt-23/sur-2 subunit, which is required for vulva development in wild-type worms, is dispensable for ectopic vulva formation in CKM mutants, which instead display hallmarks of unrestrained Mediator tail module activity. We propose a model whereby the CKM controls EGFR-Ras-ERK transcriptional output by corepressing LIN-1 and by fine tuning Mediator specificity, thus balancing transcriptional repression vs. activation in a critical developmental signaling pathway. Collectively, these data offer an explanation for CKM repression of EGFR signaling output and ectopic vulva formation and provide the first evidence of Mediator CKM-tail module subunit crosstalk in animals.
Meta-analysis of Complex Diseases at Gene Level with Generalized Functional Linear Models
Authors: Fan Ruzong , Wang Yifan , Chiu Chi-yang , Chen Wei , Ren Haobo , Li Yun , Boehnke Michael , Amos Christopher I , Moore Jason H , Xiong Momiao 
Published: December 2015

Abstract
We developed generalized functional linear models (GFLMs) to perform a meta-analysis of multiple case-control studies to evaluate the relationship of genetic data to dichotomous traits adjusting for covariates. Unlike the previously developed meta-analysis for sequence kernel association tests (MetaSKATs), which are based on mixed-effect models to make the contributions of major gene loci random, GFLMs are fixed models; i.e., genetic effects of multiple genetic variants are fixed. Based on GFLMs, we developed chi-squared-distributed Rao’s efficient score test and likelihood-ratio test (LRT) statistics to test for an association between a complex dichotomous trait and multiple genetic variants. We then performed extensive simulations to evaluate the empirical type I error rates and power performance of the proposed tests. The Rao’s efficient score test statistics of GFLMs are very conservative and have higher power than MetaSKATs when some causal variants are rare and some are common. When the causal variants are all rare [i.e., minor allele frequencies (MAF) &lt; 0.03], the Rao’s efficient score test statistics have similar or slightly lower power than MetaSKATs. The LRT statistics generate accurate type I error rates for homogeneous genetic-effect models and may inflate type I error rates for heterogeneous genetic-effect models owing to the large numbers of degrees of freedom and have similar or slightly higher power than the Rao’s efficient score test statistics. GFLMs were applied to analyze genetic data of 22 gene regions of type 2 diabetes data from a meta-analysis of eight European studies and detected significant association for 18 genes (P &lt; 3.10 × 10−6), tentative association for 2 genes (HHEX and HMGA2; P ≈ 10−5), and no association for 2 genes, while MetaSKATs detected none. In addition, the traditional additive-effect model detects association at gene HHEX. GFLMs and related tests can analyze rare or common variants or a combination of the two and can be useful in whole-genome and whole-exome association studies.
Reconciling Differences in Pool-GWAS Between Populations: A Case Study of Female Abdominal Pigmentation in Drosophila melanogaster
Authors: Endler Lukas , Betancourt Andrea J , Nolte Viola , Schlötterer Christian 
Published: December 2015

Abstract
The degree of concordance between populations in the genetic architecture of a given trait is an important issue in medical and evolutionary genetics. Here, we address this problem, using a replicated pooled genome-wide association study approach (Pool-GWAS) to compare the genetic basis of variation in abdominal pigmentation in female European and South African Drosophila melanogaster. We find that, in both the European and the South African flies, variants near the tan and bric-à-brac 1 (bab1) genes are most strongly associated with pigmentation. However, the relative contribution of these loci differs: in the European populations, tan outranks bab1, while the converse is true for the South African flies. Using simulations, we show that this result can be explained parsimoniously, without invoking different causal variants between the populations, by a combination of frequency differences between the two populations and dominance for the causal alleles at the bab1 locus. Our results demonstrate the power of cost-effective, replicated Pool-GWAS to shed light on differences in the genetic architecture of a given trait between populations.
RAD Capture (Rapture): Flexible and Efficient Sequence-Based Genotyping
Authors: Ali Omar A , O’Rourke Sean M , Amish Stephen J , Meek Mariah H , Luikart Gordon , Jeffres Carson , Miller Michael R 
Published: December 2015

AbstractMassively parallel sequencing has revolutionized many areas of biology, but sequencing large amounts of DNA in many individuals is cost-prohibitive and unnecessary for many studies. Genomic complexity reduction techniques such as sequence capture and restriction enzyme-based methods enable the analysis of many more individuals per unit cost. Despite their utility, current complexity reduction methods have limitations, especially when large numbers of individuals are analyzed. Here we develop a much improved restriction site-associated DNA (RAD) sequencing protocol and a new method called Rapture (RAD capture). The new RAD protocol improves versatility by separating RAD tag isolation and sequencing library preparation into two distinct steps. This protocol also recovers more unique (nonclonal) RAD fragments, which improves both standard RAD and Rapture analysis. Rapture then uses an in-solution capture of chosen RAD tags to target sequencing reads to desired loci. Rapture combines the benefits of both RAD and sequence capture, i.e., very inexpensive and rapid library preparation for many individuals as well as high specificity in the number and location of genomic loci analyzed. Our results demonstrate that Rapture is a rapid and flexible technology capable of analyzing a very large number of individuals with minimal sequencing and library preparation cost. The methods presented here should improve the efficiency of genetic analysis for many aspects of agricultural, environmental, and biomedical science.
Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity inChlamydomonas
Authors: Onishi Masayuki , Pringle John R , Cross Frederick R 
Published: December 2015

AbstractActin is one of the most conserved eukaryotic proteins. It is thought to have multiple essential cellular roles and to function primarily or exclusively as filaments (“F-actin”). Chlamydomonas has been an enigma, because a null mutation (ida5-1) in its single gene for conventional actin does not affect growth. A highly divergent actin gene, NAP1, is upregulated in ida5-1 cells, but it has been unclear whether NAP1 can form filaments or provide actin function. Here, we used the actin-depolymerizing drug latrunculin B (LatB), the F-actin-specific probe Lifeact-Venus, and genetic and molecular methods to resolve these issues. LatB-treated wild-type cells continue to proliferate; they initially lose Lifeact-stained structures but recover them concomitant with upregulation of NAP1. Thirty-nine LatB-sensitive mutants fell into four genes (NAP1 and LAT1–LAT3) in which we identified the causative mutations using a novel combinatorial pool-sequencing strategy. LAT1–LAT3 are required for NAP1 upregulation upon LatB treatment, and ectopic expression of NAP1 largely rescues the LatB sensitivity of the lat1–lat3 mutants, suggesting that the LAT gene products comprise a regulatory hierarchy with NAP1 expression as the major functional output. Selection of LatB-resistant revertants of a nap1 mutant yielded dominant IDA5 mutations that presumably render F-IDA5 resistant to LatB, and nap1 and lat mutations are synthetically lethal with ida5-1 in the absence of LatB. We conclude that both IDA5 and the divergent NAP1 can form filaments and redundantly provide essential F-actin functions and that a novel surveillance system, probably responding to a loss of F-actin, triggers NAP1 expression and perhaps other compensatory responses.
Vizualiojo meninio ugdymo kaitos tendencijos
Authors: Paulionytė Jûratë 
Published: December 2015

DocentėSocialinių mokslų (edukologijos) daktarėVilniaus pedagoginio universitetoUgdymo pagrindų katedraStudentų g. 39, LT-08106 VilniusTel. (8 5) 275 08 25El. paštas: jupa@vpu.lt Straipsnio tikslas – išanalizuoti šiuolaikinio vizualiojo meninio ugdymo aprėptis. To siekiant, buvo nagrinėti kai kurie naujų technologijų įtakos aspektai vizualiajam menui ir kūrybiniam procesui. Išanalizuota šiandieninė gebėjimų ugdymo vizualiųjų menų srityje meninės išraiškos specifika ir išryškinti meno pažinimo ir suvokimo ugdymo pokyčių bruožai. Atskleistos vyraujančios vizualiojo meninio ugdymo kaitos raštingumas, vizualioji kultūra.
Mokytojų vertybinės nuostatos ir jų sklaida pedagoginėje veikloje
Authors: Martišauskienė Elvyda 
Published: December 2015

Profesorė socialinių mokslų (edukologijos) habilituota daktarėVilniaus pedagoginio universitetoEdukologijos katedraStudentų g. 39, LT-08106 VilniusTel. (8-5) 279 00 42 Straipsnyje nagrinėjamas pedagogų požiūris į terminalines (siekiamas gyvenime) ir instrumentines (išugdomas, su asmens vidinėmis savybėmis susijusias) vertybes, atskleidžiami jų aukščiausi ir žemiausi reitingai. Ieškoma mokytojų vertybinių nuostatų sąsajų ir jų požiūrio į dvasinių vertybių įkūnijimą pedagoginėje veikloje ir gyvenime. Aptariami veiksniai, darantys poveikį vertybių internalizacijai.
Darbo santykių konfliktų atsiradimo priežastys ikimokyklinėse bendruomenėse
Authors: Mirzojanc Liudoslava Teresa , Survutaitė Dalia 
Published: December 2015

Vilniaus lopšelio-darželio „Kurpaitė“ direktorėTel. (8 5) 233 36 86El. paštas: sunmirage2005@yahoo.comDocentë socialinių mokslų (edukologijos) daktarėVilniaus pedagoginio universitetoEdukologijos katedraTel. 8 686 63 339El. paštas: dalisurv@vpu.lt Straipsnyje aptariami aktualūs darbo santykių klausimai švietimo sistemoje, analizuojama darbo santykių konfliktų ikimokyklinėse įstaigose įvairovė, atskleidþiamos darbo konfliktų kilimo priežastys. Darbo santykių konfliktai ikimokyklinėse įstaigose nagrinėjami vertinant vadovų, pedagogų, aptarnaujančio personalo darbuotojø nuomones.
Patyčių bendrojo lavinimo mokykloje samprata: priežasčių, formų ir pasekmių diskursas
Authors: Targamadzė Vilija , Valeckienė Džiuginta 
Published: December 2015

Vilija Targamadzė
Profesorė socialinių mokslų (edukologijos) habilituota daktarėVilniaus universiteto Filosofijos fakultetoEdukologijos katedraUniversiteto g. 9/1, LT-01513 VilniusTel. (8 5) 266 76 25El. paštas: vilija.targamadze@ku.lt

Džiuginta Valeckienė
Edukologijos doktorantė Klaipėdos universiteto Socialinės pedagogikos katedra H. Manto g. 84, LT-92264 Klaipėda Tel. + 370 686 68 575 El. paštas: dziugintalt@yahoo.com
Šiame straipsnyje analizuojama patyčių reiškinio įvardijimo problematika, patyčių mokykloje priežastys, formos, paplitimo mastai ir pasekmės, kurias jaučia tiek patyčių auka, tiek patyčių iniciatorius, tiek ir visa mokyklos bendruomenė. Patyčios yra dominuojanti agresyvaus elgesio išraiška mokykloje, kuriai būdingos tam tikros formos, sąlygota tam tikrų priežasčių. Jeigu nebus kreipiama dėmesio į tai, kad yra būdų nors kaip pažaboti patyčias, ateityje šis elgesys pasireikš daug sudėtingesnėmis agresyvaus elgesio formomis. Be to, paþymėtina, jog patyčios gali turėti ilgalaikių ir trumpalaikių pasekmių ne tik patyčių aukai, bet ir pačiam patyčių iniciatoriui.
Fundamentinės ugdymo problemos Antano Maceinos pedagogikoje
Authors: Martišauskienė Elvyda 
Published: December 2015

Profesorė socialinių mokslų (edukologijos) habilituota daktarėVilniaus pedagoginio universitetoEdukologijos katedraStudentų g. 39, LT-08106 VilniusTel. (8-5) 279 00 42El. paštas: edukologija@vpu.ltStraipsnyje nagrinėjamos A. Maceinos pedagoginės idėjos, apimančios žmogaus sampratą, grindžiamą struktūriniais komponentais (kūnu, psichika ir dvasia), atskleidžiama pedagoginės sąveikos esmė ir ypatumai, atskiriantys pedagoginį veiksmą nuo pedagoginio vyksmo, išryškinamas svarbiausių ugdymo funkcijų – lavinimo ir auklėjimo – pobūdis, suponuojantis skirtingus pedagogo vaidmenis, aptariami vaisingieji ugdymo momentai.
Antano Maceinos požiūris į naująsias pedagogikos sroves
Authors: Valatkienė Stasė 
Published: December 2015

Docentė socialinių mokslų (edukologijos) daktarėArchitektų g. 12–15Tel.: d. (85) 244 76 91, n. 244 76 81Straipsnyje atskleidžiamas Maceinos požiūris į reformistinį pedagoginį sąjūdį Vakaruose XX a. pradžioje. Pasitelkus lyginamąją analizę pateikiama Antano Maceinos naujųjų pedagogikos srovių klasifikacijos samprata, požiūris į pedagogikos istoriją. Pabrėžiama, kad autorius buvo gerai susipažinęs su užsienio mokyklos patirtimi, nuodugniai išstudijavęs moderniosios pedagogikos sroves, jų mokyklų (G. Keršenšteinerio, H. Gaudigo, G. Vynekeno ir kt.) praktiką. Pateikiamas išsamus A. Maceinos išskirtų srovių (transcendentinės, psichologinės ir vitalinės) apibūdinimas. Pažymima, kad jis ne tik smulkiai išnagrinėjo sroves kritinės analizės aspektu, bet ir išskyrė jų stiprybes ir silpnybes. Pabrėžiama, kad A. Maceina ypač aštriai pasisako prieš pedagoginį vitalizmą, nepritaria aklam užsienio patirties kopijavimui, vykdant švietimo reformą Lietuvoje.
Ugdymo kokybės vertinimas bendrojo lavinimo mokykloje: mokytojų ir mokinių požiūris
Authors: Gedminienė Daiva , Gumuliauskienė Aušrinė 
Published: December 2015

Mokytoja metodininkė, Juliaus Janonio gimnazijosdirektoriaus pavaduotoja ugdymuiTilžės g. 137, LT-76348 ŠiauliaiTel. (8 41) 52 33 75El. paštas: daiva@centras.lt lt Docentė socialinių mokslų (edukologijos) daktarėŠiaulių universiteto Edukologijos katedraP. Višinskio g. 25, LT-76351 ŠiauliaiTel. (8 41) 59 57 18El. paštas: pedagogika@cr.su.Straipsnyje nagrinėjamas mokytojų ir mokinių požiūris į ugdymo bendrojo lavinimo mokykloje kokybę, pagrindžiant jos aktualumą Europos Sąjungos ir Lietuvos švietimo raidos kontekste. Analizuojami empirinio tyrimo rezultatai, išryškinant mokytojų ir mokinių požiūrių į atskirus ugdymo proceso komponentus ir jo organizavimo aspektus bei juos sąlygojančius veiksnius panašumus ir skirtumus.
Istorinių ištakų paieška – kertinis Magdalenos Karčiauskienės pedagogikos principas
Authors: Valatkienė Stasė 
Published: December 2015

Docentė socialinių mokslų (edukologijos) daktarėErfurto g. 12–15, LT-04116 VilniusTel. (8 5) 2 44 76 91Šiame straipsnyje lyginamosios analizės metodu siekiama atskleisti profesorės Magdalenos Karčiauskienės požiūrį į pedagoginių reiškinių vertinimą istoriniu aspektu. Taip pat norima pristatyti mokslininkės istorinių ištakų paieškų sampratą ir pagrįsti istorinio perimamumo principo taikymo svarbą šiuolaikinei Lietuvos mokyklai ir pedagogikos mokslo teorijai.