bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact evaluation of “Have Fun — Be Healthy” program: A community based health promotion intervention to prevent childhood obesity
Authors: Pathirana Thanya , Stoneman Rebecca , Lamont Amanda , Harris Neil , Lee Patricia 
Published: December 2017

AbstractIssue addressedChildhood obesity is rising in prevalence in Australia. This study aimed to evaluate the impact of the “Have Fun—Be Healthy” (HFBH) intervention, delivered in the Playgroup setting, to generate short term changes in dietary, physical activity and sedentary behaviours of children under 5 years and self‐efficacy of parents and primary carers.MethodsThis intervention consisted of eight structured cooking and physical play sessions delivered over a period of 8 weeks by trained facilitators. Pre‐ and post‐intervention data collection was performed using survey questionnaires administered to parents and carers of children under 5 years from low socioeconomic backgrounds recruited through convenience sampling.ResultsA total of 640 pre‐intervention surveys and 312 post‐intervention surveys were returned. The matched response rate was 45.5%. There was an improvement in mean intake of healthy foods and mean physical activity with a decrease in mean intake of unhealthy food and mean screen time in children (P > .05). Following the intervention, parental/carer self‐efficacy in promoting healthy eating and limiting screen time of children improved significantly (P < .05). Children's physical activity levels and consumption of healthy foods were positively correlated with parental/carer self‐efficacy (P < .01) while screen time and consumption of unhealthy foods were negatively correlated (P < .01).ConclusionsHFBH intervention was successful in improving the dietary, physical activity and screen time in children and parental self‐efficacy.So what?Being amongst the first of its’ kind in Australia, the findings of this study can have implications for developing and implementing similar future health promotion interventions in comparable settings.
Hello Sunday Morning: Strategies used to support temporary alcohol abstinence through participation in an online health promotion program
Authors: Pennay Amy , MacLean Sarah , Rankin Georgia , O'Rourke Sean 
Published: December 2017

AbstractIssue addressedHello Sunday Morning (HSM) is an online program that encourages people to commit to a period of non‐drinking and blog about their experiences. Among a sample of Victorian HSM users, we aimed to explore the barriers faced and the strategies adopted to maximise potential for achieving temporary abstinence.MethodsA content analysis of blog data from 154 HSM users (a total of 2844 blog posts) was undertaken by three researchers. Participants were predominantly women aged 30‐50 years.ResultsThe most common barriers to achieving temporary alcohol abstinence reported by participants were stress and tiredness, pervasiveness of drinking in social life, negative effects from not drinking and negative reactions from others. The strategies most commonly implemented included drawing on HSM and other non‐drinking networks, self‐talk, engaging in non‐alcohol‐related activities and substituting alcohol with other drinks.ConclusionsAlthough significant individual and systemic barriers to abstaining from alcohol were identified by HSM users, multiple strategies were identified and effectively utilised to overcome these barriers.So what?We suggest that the virtual support from an online community with a shared interest in reducing their alcohol use appears to be a useful health promotion strategy for temporarily reducing consumption, particularly for women.
Recent Progress in Gas Phase Cucurbit[n]uril Chemistry
Authors: Shen Jiewen , Dearden David V. 
Published: December 2017

AbstractCucurbit[n]urils (CB[n]s) are of great significance due to their unique molecular recognition properties and their potential applications in areas such as drug delivery or analytical assays. Gas phase studies, without interference from solvents or counterions, provide fundamental insights into the mechanism of CB[n] complex formation and binding. In this paper, we review the progress in gas phase CB[n] chemistry, mainly based on mass spectrometry, since 2011, including important discoveries in structural studies, mechanistic studies, and gas phase studies related to analytical or clinical applications of CB[n]s. We expect the use of gas phase methods to continue to expand and diversify.
MALDI imaging detects endogenous digoxin in glioblastoma cells infected by Zika virus—Would it be the oncolytic key?
Authors: Lima Estela de O. , Guerreiro Tatiane M. , Melo Carlos Fernando O.R. , de Oliveira Diogo N. , Machado Daisy , Lancelloti Marcelo , Catharino Rodrigo R. 
Published: December 2017

AbstractRecently, microcephaly cases have increased in Americas and have been matter of concern due to Zika virus (ZIKV) recent outbreak. Previous studies have shown that ZIKV‐infected progenitor neuronal cells present morphological abnormalities and increased rates of cell death, which may be indicators of microcephaly causes. As recent studies indicate ZIKV' tropism for brain cells, how would a glioblastoma (GBM) lineage behave under ZIKV infection, considering GBM the most common and malignant brain tumor in adults, presenting extreme chemoresistance and high morbidity and mortality rates? The current trend of using genetically engineered oncolytic pathogens as a safe way to eliminate tumors is under development, with trials already in course. Therefore, the present study evaluated the possible oncolytic effects and metabolomic alterations of ZIKV infection at human malignant M059J GBM cells. Microscopic evaluation was performed by using optical microscopy, which showed cytopathic effects induced by ZIKV at GBM cells. For the metabolomics study, both control and infected cell cultures were submitted to matrix laser desorption/ionization mass spectrometry imaging analysis. Mass spectrometry data were submitted to partial least squares discriminant analysis statistical analysis, and distinct biomarkers were elected for each infected groups. This study brings light to unexpectedly induced metabolic changes, as endogenous digoxin as important biomarker for ZIKV‐GBM group, associated with cytopathic effects induced by viral infection. These result evidences that genetically engineered ZIKV might be a potential new strategy for neural cancer management through the induction of endogenous digoxin synthesis in GBM cells.
An optimized method for correcting fluorescence quenching using optical backscattering on autonomous platforms
Authors: Thomalla Sandy J. , Moutier William , Ryan‐Keogh Thomas J. , Gregor Luke , Schütt Julia 
Published: December 2017

AbstractAutonomous platforms will begin to address the space‐time gaps required to improve estimates of phytoplankton distribution, which will aid in the quantification of baseline conditions necessary to detect long‐term trends that can be attributed to factors such as climate change. However, there is a need for high quality controlled and verified datasets. In vivo fluorescence provides a proxy for chlorophyll pigment concentration, but it is sensitive to physiological downregulation under incident irradiance (fluorescence quenching). Quenching can undermine the validity of these datasets by underestimating daytime fluorescence derived chlorophyll across regional and temporal scales. Existing methods from the literature have corrected for quenching, however, these methods require certain assumptions to be made that do not hold true across all regions and seasons. The method presented here overcomes some of these assumptions to produce corrected surface fluorescence during the day that closely matched profiles from the previous (or following) night, decreasing the difference to less than 10%. This method corrects daytime quenched fluorescence using a mean nighttime profile of the fluorescence to backscattering ratio multiplied by daytime profiles of backscattering from the surface to the depth of quenching (determined as the depth at which the day fluorescence profile diverges from the mean night profile). This method was applied to a 7‐month glider time series in the sub‐Antarctic Southern Ocean together with four other methods from the literature for comparison. In addition, the method was applied to a glider time series from the North Atlantic to demonstrate its applicability to other ocean regions.
‐subgroups in the space Cremona group
Authors: Prokhorov Yuri , Shramov Constantin 
Published: December 2017

AbstractWe prove that if X is a rationally connected threefold and G is a p‐subgroup in the group of birational selfmaps of X, then G is an abelian group generated by at most 3 elements provided that . We also prove a similar result for under an assumption that G acts on a (Gorenstein) G‐Fano threefold, and show that the same holds for under an assumption that G acts on a G‐Mori fiber space.
Hyperpolarized 13C,15N2‐urea T2 relaxation changes in acute kidney injury
Authors: Mariager Christian Østergaard , Nielsen Per Mose , Qi Haiyun , Ringgaard Steffen , Laustsen Christoffer 
Published: December 2017

PurposeTo investigate the correlation between renal ischemia and 13C‐urea T2 relaxation rate in an acute kidney injury (AKI) rat model.MethodsSix rats subjected to unilateral renal ischemia were investigated. Creatinine clearance, urine output, plasma creatinine as well as blood‐urea nitrogen (BUN) values were acquired before and after the procedure. 1H
mapping was acquired using blood oxygenation level dependent (BOLD) MRI and hyperpolarized 13C‐urea T2 mapping was acquired using a 2D golden‐angle radial approach. Kidney perfusion was estimated using noncontrast flow alternating inversion recovery arterial spin labeling.ResultsAll rats showed clinical signs of AKI with increased plasma creatinine and increased BUN. Whole kidney 13C‐urea T2 significantly decreased 26% (P = 0.001) 24 h after reperfusion. A significantly different (3.7 times steeper; P = 0.008) osmolality gradient was observed in the contralateral kidney (P = 0.008; R2 = 0.86) compared with the postischemic kidney (P = 0.0004, R2=0.97). Whole kidney
signal (P = 0.14) and
gradient (P = 0.26) was similar between the two kidneys. Oxygen availability dependency on 13C‐urea T2 was investigated by means of the correlation between the BOLD and T2 signals; a statistically significant difference (P = 0.03) was found in the contralateral kidney (P = 0.0001; R2 = 0.95), but not in the postischemic kidney (P = 0.31; R2 = 0.25).ConclusionWe demonstrate that hyperpolarized [13C,15N2]urea T2 relaxation correlates with renal oxygen tension (
) in the healthy contralateral kidney, but not in the postischemic kidney. The whole kidney T2 relaxation difference between the postischemic and contralateral kidney may originate from altered blood volume in the postischemic kidney. Magn Reson Med 80:696–702, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
An industrial design solution for integrating NMR magnetic field sensors into an MRI scanner
Authors: Kennedy Michael , Lee Yoojin , Nagy Zoltan 
Published: December 2017

PurposeNeuroimaging research relies on the skills of increasingly multidisciplinary individuals and often requires the installation and use of additional home‐built or third‐party equipment. The purpose of the present work was the safe, ergonomic, durable, and aesthetically pleasing installation of magnetic field monitoring equipment into a scanner, while keeping the setup compatible with standard operating procedures.MethodsAn extensive set of steps was required to design a 3D printed solution to install a magnetic field camera into the eight‐channel head coil of a 3T MRI scanner. First, the outer surface of the plastic coil housing was recreated into a 3D model, and the installation of the magnetic field sensors around this 3D model was performed in a virtual environment. The 3D printed solution was then assembled and tested for safety, reproducible performance, and image quality.ResultsThe 3D printed solution holds the probes in stable positions and guides the necessary cables in an organized fashion and away from the volunteer. Assembly is easy and the solution is ergonomic, durable, and safe. We did not find excessive heating in the 3D printed parts, nor in the electronics, that they help to incorporate. The material used interferes minimally with transmit
field.ConclusionThe design met all of the boundary conditions for a durable, safe, cost‐effective, attractive, and functional installation. This work will provide the basis for installing the magnetic field sensors into other available head coils, and for designing the experimental setup for projects with varying experimental requirements. Magn Reson Med 80:833–839, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Strategic spectrum occupancy for secondary users in cognitive radio networks with retrials
Authors: Wang Jinting , Wang Fang , Li Wei Wayne 
Published: December 2017

AbstractThis article investigates joining strategies and admission control policy for secondary users (SUs) with retrial behavior in a cognitive radio (CR) system where a single primary user (PU) coexists with multiple SUs. Under a certain reward‐cost structure, SUs opportunistically access the PU band when it is not occupied by the PU. If the band is available upon arrival, an SU decides with a probability either to use the band immediately or to balk the system. If the band is occupied, the SU must decide whether to enter the system as a retrial customer or to leave the system. Once the PU requests for service, the service of SU being served, if any, will be interrupted, and the interrupted SU leaves the band and retries for service after a random amount of time. In this article, we study the equilibrium behavior of non‐cooperative SUs who want to maximize their benefit in a selfish, distributed manner with delay‐sensitive utility function. The socially optimal strategies of SUs are also derived. To utilize the PU band more efficiently and rationally, an admission control policy is proposed to regulate SUs who enter the system in order to eliminate the gap between the individually and socially optimal strategies.
Musculoskeletal complications following total body irradiation in hematopoietic stem cell transplant patients
Authors: Jackson Taylor J. , Mostoufi‐Moab Sogol , Hill‐Kayser Christine , Balamuth Naomi J. , Arkader Alexandre 
Published: December 2017

AbstractTotal body irradiation (TBI) is commonly used in conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT) to treat benign and malignant disease. Though life‐saving, these therapies place patients at risk for important side effects, including musculoskeletal complications such as short stature, osteonecrosis, slipped capital femoral epiphysis, and the development of benign and malignant bone tumors. With an increasing number of HSCT survivors, there is a growing need for awareness of the musculoskeletal complications of HSCT and TBI.
High incidence of acute kidney injury during chemotherapy for childhood acute myeloid leukemia
Authors: Du Plessis Liezl , Rassekh Shahrad Rod , Mammen Cherry 
Published: December 2017

AbstractBackground/objectivesChildhood acute myeloid leukemia (AML) is a rare and heterogeneous disease. Pediatric data on the epidemiology of acute kidney injury (AKI) in AML are limited. We report on the incidence of AKI in childhood AML and the risk factors associated with AKI episodes.MethodsA retrospective cohort of 53 patients (≤18 years), with de novo AML, receiving chemotherapy over a 10‐year period. All serum creatinine (SCr) levels during therapy‐related hospitalizations were assessed to stage AKI episodes as per Kidney Disease: Improving Global Outcomes criteria. Severe AKI was defined as AKI stages 2 or 3 and urine output criteria were not used. AKI risk factors were assessed independently in both cycle 1 alone and combining all chemotherapy cycles.ResultsAKI developed in 34 patients (64%) with multiple AKI episodes in 10 patients (46 total episodes). Twenty‐four severe AKI episodes occurred in 23 patients (43.4%) with a mean duration of 26.1 days (SD 7.3). In cycle 1, hyperleukocytosis was not predictive of AKI, but severe sepsis was an independent risk factor of severe AKI (odds ratio [OR]: 13.4; 95% CI 1.9–94.9). With cycles combined, all subjects with AKI had severe sepsis and older age (≥10 years) was associated with severe AKI (OR: 20.8; 95% CI 3.8–112.2).ConclusionThere was a high incidence of AKI in our AML cohort with a strong association with older age (≥10 years) and severe sepsis. Larger prospective studies are needed to confirm the high burden of AKI and risk factors in this susceptible population.
Crizotinib in ALK+ inflammatory myofibroblastic tumors—Current experience and future perspectives
Authors: Theilen Till‐Martin , Soerensen Jan , Bochennek Konrad , Becker Martina , Schwabe Dirk , Rolle Udo , Klingebiel Thomas , Lehrnbecher Thomas 
Published: December 2017

AbstractInflammatory myofibroblastic tumor (IMT) and its subtype epithelioid inflammatory myofibroblastic sarcoma (EIMS) are rare soft‐tissue tumors. As about 50% of IMT and 100% of EIMS contain activating rearrangements of the anaplastic lymphoma kinase (ALK) gene, targeted kinase inhibition of ALK by compounds such as crizotinib is a potential treatment option. We performed a literature review and analyzed a total of 30 patients with IMT/EIMS treated with crizotinib. A total of 12 patients achieved complete or partial remission. As preliminary data are promising, a prospective study evaluating crizotinib treatment in patients with unresectable/multifocal ALK+ IMT/EIMS is warranted.
Family history‐taking practices and genetic confidence in primary and tertiary care providers for childhood cancer survivors
Authors: Wakefield Claire E. , Quinn Veronica F. , Fardell Joanna E. , Signorelli Christina , Tucker Katherine M. , Patenaude Andrea F. , Malkin David , Walwyn Thomas , Alvaro Frank , Cohn Richard J. 
Published: December 2017

AbstractBackgroundThere is growing impetus for increased genetic screening in childhood cancer survivors. Family history‐taking is a critical first step in determining survivors’ suitability. However, the family history‐taking practices of providers of pediatric oncology survivorship care and the confidence of these providers to discuss cancer risks to relatives are unknown.ProcedureFifty‐four providers completed semistructured interviews in total, which included eight tertiary providers representing nine hospitals across two countries (63% male, 63% oncologists, 37% nurses) and 46 primary care providers (PCPs) nominated by a survivor (59% male, 35% regional practice). We used content analysis and descriptive statistics/regression to analyze the data.ResultsFew tertiary (38%) or primary (35%) providers regularly collected survivors’ family histories, often relying on survivors/parents to initiate discussions. Providers mostly took two‐generation pedigrees (63% tertiary and 81% primary). Primary providers focused on adult cancers. Lack of time, alternative priorities, and perceived lack of relevance were common barriers. Half of all tertiary providers felt moderately comfortable discussing genetic cancer risk to children of survivors (88% felt similarly discussing risks to other relatives). Most primary providers lacked confidence: 41% felt confident regarding risks to survivors’ children and 48% regarding risks to other relatives.ConclusionsWhile family history‐taking will not identify all survivors suitable for genetics assessment, recommendations for regular history‐taking are not being implemented in tertiary or primary care. Additional PCP‐targeted genetic education is warranted given that they are well placed to review family histories of pediatric cancer survivors.
ETV6–NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study
Authors: Vokuhl Christian , Nourkami‐Tutdibi Nasenien , Furtwängler Rhoikos , Gessler Manfred , Graf Norbert , Leuschner Ivo 
Published: December 2017

AbstractBackgroundCongenital mesoblastic nephroma (MN) is a rare pediatric renal tumor representing approximately 5% of all pediatric renal tumors. Three different types of MN are distinguished histologically: classical, cellular, and mixed. A frequent genetic alteration is the translocation t(12;15) resulting in a fusion of the ETV6 gene on 12p13 and the NTRK3 gene on 15p15 that occurs almost exclusively in cellular MN. The aim of this study was to determine translocation status of a large cohort of MN with respect to tumor subtype and outcome.ProcedureIn total, clinical data from 111 patients were available. Sixty‐seven tumors were classical MN (51%), 29 cellular MN (31%), and 15 were mixed MN (18%). From these 111 cases, 79 were analyzed by FISH and RT‐PCR.ResultsAll classical and mixed MN were translocation negative. Seventeen out of 29 (58%) cellular MN harbored the ETV6–NTRK3 translocation. Five‐year relapse‐free survival (RFS) and overall survival (OS) were 93.2% and 96.8% for the complete cohort. All seven relapses occurred in translocation negative tumors. Five‐year RFS was significantly inferior for cellular and mixed MN compared to classic MN (89%, 80%, and 98%), whereas 5‐year OS was similar (93%, 96%, and 98%). Within the group of cellular MN, patients having translocation‐positive tumors had a significantly superior RFS (5‐year RFS: 100% vs. 73%).ConclusionThe majority of cellular MNs harbor the ETV6–NTKR3 gene fusion, whereas all classic‐ and mixed‐type MNs were translocation negative. Within the cellular subgroup, patients having translocation‐positive tumors had a significantly superior RFS.
Cytoreductive surgery and hyperthermic intraperitoneal perfusion with chemotherapy in children with peritoneal tumor spread: A French nationwide study over 14 years
Authors: Scalabre Aurélien , Philippe‐Chomette Pascale , Passot Guillaume , Orbach Daniel , Elias Dominique , Corradini Nadège , Brugières Laurence , Msika Simon , Leclair Marc‐David , Joseph Solène , Brigand Cécile , Becmeur François , Soler Christine , Pezet Denis , Gagniere Johan , Glehen Olivier , Sarnacki Sabine 
Published: December 2017

AbstractBackgroundEfficacy and role of cytoreductive surgery (CRS) and hyperthermic peritoneal perfusion with chemotherapy (HIPEC) remain poorly documented in pediatric tumors.MethodsThis retrospective national study analyzed all pediatric patients with peritoneal tumor spread treated by CRS and HIPEC as part of a multimodal therapy in France from 2001 to 2015.ResultsTwenty‐two patients (nine males and 13 females) were selected. The median age at diagnosis was 14.8 years (4.2–17.6). Seven had peritoneal mesotheliomas; seven, desmoplastic small round cells tumors (DSRCT); and eight, other histologic types. A complete macroscopic resection (CC‐0, where CC is completeness of cytoreduction) was achieved in 16 (73%) cases. Incomplete resections were classified as CC‐1 in four (18%) cases and CC‐2 in two (9%) cases. Fourteen (64%) patients had complications within 30 days from HIPEC, requiring an urgent laparotomy in eight (36%) cases. Thirteen (59%) patients received adjuvant chemotherapy and four (18%) received total abdominal radiotherapy after surgery. Sixteen (72%) patients had relapse after a median time of 9.6 months (1.4–86.4) and nine (41%) eventually died after a median time of 5.3 months (0.1–36.1) from relapse. Six (27%) patients (four mesotheliomas, one pseudopapillary pancreatic tumor, and one DSRCT) were alive and in complete remission after a median follow‐up of 25.0 months (5.3–78.2).The mean overall survival (OS) and disease‐free survival (DFS) were 57.5 months (95% CI [38.59–76.32]) and 30.9 months (95% CI [14.96–46.77]). Patients with a peritoneal mesothelioma had a significantly better OS (p = 0.015) and DFS (p = 0.028) than other histologic type.ConclusionsIn this national series, outcomes of HIPEC are encouraging for the treatment of peritoneal mesothelioma in children.