bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraspecific crop diversity for enhanced crop pollination success. A review
Authors: Chabert Stan , Eeraerts Maxime , DeVetter Lisa W. , Borghi Monica , Mallinger Rachel E. 
Published: October 2024

AbstractInterspecific crop diversity (e.g., intercropping) has been documented to promote sustainability in agroecological systems with benefits for pollination services and insect pollinators. These benefits may also be extended to intraspecific crop diversity (e.g., cultivation of multiple genotypes or cultivars in a production space), but no review to date has examined the benefits of intraspecific crop diversity for pollination and pollinator communities. While mixing cultivars is necessary and a widespread practice for pollination of self-incompatible or male-sterile crops, it is not as widespread for other crop species. However, many other crops have shown reduced yield quantity or quality with self-fertilization due to partial self-sterility, early acting inbreeding depression, and xenia. These crops could thus experience increased production in diverse cultivar mixtures. Cultivar mixtures could also benefit pollinator communities through providing complementary and temporally consistent floral resources, with cascading effects on pollination services. However, successfully implementing cultivar mixtures requires an understanding of how cultivar identity and arrangement affect successful cross-pollination. In this review, we describe the potential benefits of increased intraspecific crop diversity for optimal pollination and pollinator populations across insect-pollinated crops. Additionally, we explore how research advances in cultivar characteristics and insect pollinator behavior and movement, as well as crop pollen flow, can inform cultivar mixtures and spatial arrangements. We find evidence that mixing cultivars, even in self-compatible crops, improves pollination outcomes and yields. Additionally, given insect pollinator behavior and pollen flow, such mixing must occur at relatively small spatial scales. Furthermore, cultivar diversity could ensure successful pollination and resource production for pollinators under extreme weather events. We also discuss costs and benefits of diverse cultivar mixtures from a grower’s perspective and offer suggestions for future research including translating findings within the context of farming systems so that recommendations are practical and achievable.
Management of cytotoxic chemotherapy in patients undergoing dialysis: a still unresolved issue of onconephrology
Authors: Pirovano Marta , Ganini Carlo , Gallieni Maurizio , Porta Camillo , Cosmai Laura 
Published: October 2024

Abstract
The incidence of tumors increases significantly in individuals with chronic kidney disease (CKD), particularly among those undergoing dialysis. This dialysis-associated condition not only impacts therapy but also influences the prognosis of oncological patients, contributing to heightened mortality rates related to both cancer and non-cancer causes. Importantly, it stands as a primary factor leading to suboptimal utilization of therapies. Dosage adjustment for many types of chemotherapy is a necessity in patients with kidney impairment. However, due to a lack of comprehensive knowledge about the pharmacokinetic and pharmacodynamic properties of these drugs in dialysis, adjustments are often made empirically, and in many cases, chemotherapy is avoided altogether. In this review, we highlight the current challenges and gaps in knowledge, and emphasize the imperative need for dedicated research to establish evidence-based guidelines for chemotherapy management in this vulnerable patient population.

Graphical abstract
Odontogenic myxoma of the maxilla: a case report
Authors: Saha Ashmita , Tummidi Santosh , Ghosh Debangshu , Bhattacharya Souvik 
Published: October 2024

Abstract
Background
Odontogenic myxomas are rare tumours of the mesenchymal portion of developing tooth and account for 3–6% of all odontogenic tumours. Microscopically, odontogenic myxomas have a characteristic histologic appearance, which distinguishes it from other odontogenic tumours. However, it can mimic normal dental follicles of a developing tooth, from which it can be differentiated histologically by the nature of connective tissue and also by clinical and radiological appearances.

Case presentation
We present a case of a 30-year-old female with a large mass involving the left maxillary sinus. Histopathology showed features of odontogenic myxoma.

Discussion
Early diagnosis of such lesions is critical for avoiding extensive surgical procedures and the subsequent impact on the patient’s quality of life.

Conclusion
Complete surgical excision is the treatment choice, which can be difficult owing to the tumour’s invasive borders. Hence, the patients should benefit from regular follow-ups.
Of other reefs: designing habitats in blasted seascapes
Authors: Weber Rasa 
Published: October 2024

Abstract
Migrating reefs, unprecedented species assemblages, neophytes, toxicities, pollutants, aquatic ruins – The future of coral reefs in the Anthropocene is likely to look different from anything we have experienced so far. While the classic conservation debate on coral reef restoration still treats these ecosystems as “sick patients,” a radically different view of convivial conservation is beginning to challenge exclusive human control over these endangered habitats. Putting aside notions of natural “purity” and adopting a much more humble and highly interconnected perspective on marine habitats, we can begin to see reefs as transformative, sympoïetic and blasted seascapes for a convivial future. The discipline of biodesign has been primarily focussed on researching ecological relationships with regard to new materials and products. The emerging interest in shaping the multi-layered ecological relationships of habitats for other-than-human lives, however, is steering design practice towards terraforming or, in the case of marine environments, “aquaforming.” This paper argues for taking convivial conservation practices in marine environments as a starting point for the development of a new design methodology that focuses on the design of living systems in open environments: a proposed methodology called Sympoïetic Design.
Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future
Authors: Adam Stacey J. , Buchman Timothy G. , Currier Judith S. , Draghia-Akli Ruxandra , Fessel Josh P. , Higgs Elizabeth S. , Hughes Eric A. , LaVange Lisa , Menetski Joseph P. , Read Sarah W. , Rosenberg Yves , Tressler Randall ,   ACTIV Therapeutics-Clinical Working Group
Published: October 2024

Abstract
The Accelerating COVID-19 Therapeutic Interventions and Vaccines Therapeutic-Clinical Working Group members gathered critical recommendations in follow-up to lessons learned manuscripts released earlier in the COVID-19 pandemic. Lessons around agent prioritization, preclinical therapeutics testing, master protocol design and implementation, drug manufacturing and supply, data sharing, and public–private partnership value are shared to inform responses to future pandemics.
Lessons learned from the conduct of inpatient clinical trials in a pandemic
Authors: O’Halloran Jane A. , Beitler Jeremy R. , Chung Lucy K. , Jain Mamta K. , Khan Akram , Merck Lisa H. , Mourad Ahmad , Oh Minn A. , Sharma Shweta , Yokum Tammy , Nayak Seema U. 
Published: October 2024

Abstract

Background:
The COVID-19 pandemic amplified known challenges associated with the conduct of inpatient clinical trials, while also introducing new ones that needed to be addressed.

Methods:
Stakeholders based in the United States who participated in the conduct of inpatient therapeutic trials for the treatment of COVID-19 as part of the Accelerating COVID-19 Therapeutic Interventions and Vaccines program identified challenges experienced in the conduct of these trials through a series of meeting to discuss and identify common themes. In addition, innovations developed to address these challenges and other potential solutions that may be utilized in future pandemics were highlighted.

Results:
Six thematic challenges including infection control considerations, the interplay between provision of clinical care and research, competing clinical trials, arduous consenting procedures, onerous procedural requirements, and participant recruitment including achieving representation of diverse populations were identified and are discussed here.

Conclusions:
Consideration of the lessons learned and recommendation outlined here may allow for more efficient conduct of inpatient clinical trials in future pandemics.
Practical application of good participatory practices for trials of emerging pathogens: Developing materials for use in ACTIV-3, -3b, and ACTIV-associated COVID-19 trials
Authors: Guerra-de-Blas Paola del Carmen , Marines-Price Rubria , Milman Olga , Deal Danae , Marchand Jonathan , Linton Jessica , Meger Sue , Rule John , Holland Thomas L. , Kitonsa Jonathan , Delph Yvette ,   for the INSIGHT OTAC, ACTIV-3 TICO, ACTIV-3 substudy VATICO, and ACTIV-3b TESICO Study Groups
Published: October 2024

Abstract
The emergence of the COVID-19 pandemic required an immediate global clinical research response. The ACTIV (Accelerating COVID-19 Therapeutic Interventions and Vaccines)-3 trials and the ACTIV-associated Outpatient Treatment with Anti-Coronavirus Immunoglobulin trial used Good Participatory Practices (GPP) to develop materials for study implementation from a global network perspective. GPP guidelines offer a framework for engaging stakeholders throughout the research process. This paper provides an overview of the materials developed and their applicability in various settings, reports results from a survey of study site personnel on the materials’ usefulness, summarizes important lessons learned, and serves as a reference for networks eager to apply GPP. Survey results showed that flipbooks and overview videos were highly ranked. Stakeholder input was valuable in developing easily understandable participant-facing materials with culturally appropriate images. Materials should be available to submit with the initial protocol submissions to ethics committees, and in formats that accommodate a wide range of institutional resources, policies, and infection-control practices. This article emphasizes the importance of GPP, including stakeholder consultation, in developing materials that support clinical research and address language, cultural, and sociopolitical barriers during a pandemic. The findings will be used to optimize efforts and resource allocation for new and ongoing studies.
ACTIV trials: cross-trial lessons learned for master protocol implementation
Authors: Keshtkar-Jahromi Maryam , Adam Stacey J. , Brar Indira , Chung Lucy K. , Currier Judith S. , Daar Eric S. , Davey Victoria J. , Denning Eileen T. , Gelijns Annetine C. , Higgs Elizabeth S. , Jagannathan Prasanna , Javan Arzhang Cyrus , Jensen Tomas O. , Jilg Nikolaus , Kalomenidis Ioannis , Kim Peter , Nayak Seema U. , Newell Matthew , Taiwo Babafemi O. , Yokum Tammy , Delph Yvette 
Published: October 2024

Abstract
The United States Government (USG) public-private partnership “Accelerating COVID-19 Treatment Interventions and Vaccines” (ACTIV) was launched to identify safe, effective therapeutics to treat patients with Coronavirus Disease 2019 (COVID-19) and prevent hospitalization, progression of disease, and death. Eleven original master protocols were developed by ACTIV, and thirty-seven therapeutic agents entered evaluation for treatment benefit. Challenges encountered during trial implementation led to innovations enabling initiation and enrollment of over 26,000 participants in the trials. While only two ACTIV trials continue to enroll, the recommendations here reflect information from all the trials as of May 2023. We review clinical trial implementation challenges and corresponding lessons learned to inform future therapeutic clinical trials implemented in response to a public health emergency and the conduct of complex clinical trials during “peacetime,” as well.
Case C-80/23: A Quest for Clarity. The Law Enforcement Directive 2016/680, a Bulgarian Court and Case C-205/21
Authors: Nikiforov Liubomir 
Published: October 2024

AbstractThis contribution examines the legal intricacies surrounding law enforcement data collection practices in Bulgaria within the framework of the Law Enforcement Directive 2016/680 (LED) and relevant Court of Justice of the European Union (CJEU) rulings, particularly cases C-205/21 and C-80/23. The analysis underscores challenges in interpreting the concept of “strict necessity” and ensuring compliance with its provisions, in particular, Art. 10. Key findings reveal ambiguities in the LED’s application, particularly concerning judicial review and the scope of data collection. The subsequent Case C-80/23 further seeks clarification on the strict necessity standard and the scope of judicial review in the collection of biometric and genetic data. The outcome of both cases has broader implications for EU member states, highlighting the need for legislative alignment and underscoring the complexities and challenges in balancing effective law enforcement with the protection of fundamental rights.
Impact of coffee-derived chlorogenic acid on cognition: a systematic review and meta-analysis
Authors: Johal Karen , Jones Dan J. W. , Bell Lynne , Lovegrove Julie A. , Lamport Daniel Joseph 
Published: October 2024

Abstract
Coffee drinking has been associated with benefits for various health outcomes, with many attributed to the most prevalent family of polyphenols within coffee, chlorogenic acids (CGA). Whilst reviews of the association between coffee and cognition exist, evidence exploring effects of coffee-specific CGA on cognition has yet to be systematically synthesised. The purpose was to systematically review the current literature investigating the relationship between CGA from coffee and cognitive performance. A further objective was to undertake a meta-analysis of relevant randomised controlled trials (RCT). Observational and intervention studies were included if they considered coffee-based CGA consumption in human participants and applied a standardised measure of cognition. Furthermore, intervention studies were required to define the CGA content and include a control group/placebo. Studies were excluded if they examined CGA alone as an extract or supplement. A search of Scopus, PubMed, Web of Science, ScienceDirect and PsycINFO resulted in including twenty-three papers, six of which were interventions. The evidence from the broader systematic review suggests that CGA from coffee may need to be consumed chronically over a sustained period to produce cognitive benefits. However, the meta-analysis of RCT showed no benefits of coffee CGA intake on cognitive function (d = 0.00, 95% CI −0.05, 0.05). Overall, this review included a limited number of studies, the sample sizes were small, and a wide range of cognitive measures have been utilised. This indicates that further, good-quality interventions and RCT are required to systematically explore the conditions under which coffee CGA may provide benefits for cognitive outcomes.
LASSOing the Governor’s Mansion: A Machine-Learning Approach to Forecasting Gubernatorial Elections
Authors: Love Gregory J. , Carlin Ryan E. , Singer Matthew M. 
Published: October 2024

ABSTRACT
Despite governors’ crucial roles in shaping important policies, including abortion, education, and infrastructure, forecasters have paid little attention to gubernatorial elections. We posit that institutional idiosyncrasies and lack of public opinion data have exacerbated the classic problem facing all election forecasts: there are too many predictors and too few cases, leading to overfitting. To address these problems, we combine new governor and state-level presidential approval data with a machine-learning approach, LASSO, for variable selection. LASSO examines numerous variables but retains only those that substantively improve model performance. Results demonstrate the efficacy of gubernatorial and presidential approval ratings measured two quarters preelection in predicting both incumbent-party vote share and election winners in out-of-sample predictions. For 2022, our approach outperformed the Cook Political Report’s Partisan Voting Index and compared well with 538’s Election Day prediction. For 2024, our LASSO-Popularity model predictions indicate that it will likely be a difficult year for Democrats in gubernatorial contests.
Source Geometry and Rupture Characteristics of the 20 February 2023 Mw 6.4 Hatay (Türkiye) Earthquake at Southwest Edge of the East Anatolian Fault
Authors: Yolsal‐Çevikbilen Seda , Taymaz Tuncay , Irmak Tahir Serkan , Erman Ceyhun , Kahraman Metin , Özkan Berkan , Eken Tuna , Öcalan Taylan , Doğan Ali Hasan , Altuntaş Cemali 
Published: October 2024

AbstractFollowing the catastrophic 6 February 2023 Mw 7.8 and Mw 7.6 Kahramanmaraş earthquakes in the East Anatolian Fault Zone (EAFZ; southeast Türkiye), numerous aftershocks occurred along the major branches of this left‐lateral shear zone. The spatio‐temporal distribution of the earthquakes implied the stress‐triggering effects of co‐seismic ruptures on closely connected fault segments over large distances. On the 20 February 2023 two earthquakes with Mw 6.4 and Mw 5.2 struck Hatay (Türkiye) located near the Samandağ‐Antakya segment of the EAFZ. To understand the rupture evolution of these earthquakes, we first re‐located the aftershock sequence that occurred over a 3‐month period in the Hatay‐Syria region. A normal faulting mechanism with a significant amount of left‐lateral strike‐slip component at a shallow focal depth of 12 km was estimated for the 2023 Mw 6.4 earthquake from the inversion of seismological data. Our slip models describe a relatively simple and unilateral rupture propagation along about 36 km‐long active segments of the EAFZ. The co‐seismic horizontal displacements inferred from the Global Navigation Satellite System data are compatible with the oblique slip kinematics. Furthermore, we suggest that this earthquake did not produce notable tsunami waves on the adjacent coasts since the rupture plane did not extend to the seafloor of the Eastern Mediterranean with substantial amount of vertical displacement. We reckon that a future large earthquake (Mw ≥ 7.0) in the Hatay‐Syria region where increased stress was transferred to the fault segments of the EAFZ and the Dead Sea Fault Zone (DSFZ) after the 2023 earthquakes will be a probable source of tsunami at the coastal plains of the Eastern Mediterranean Sea region.
Designing a Fully‐Tunable and Versatile TKE‐l Turbulence Parameterization for the Simulation of Stable Boundary Layers
Authors: Vignon É. , Arjdal K. , Cheruy F. , Coulon‐Decorzens M. , Dehondt C. , Dubos T. , Fromang S. , Hourdin F. , Lange L. , Raillard L. , Rivière G. , Roehrig R. , Sima A. , Spiga A. , Tiengou P. 
Published: October 2024

AbstractThis study presents the development of a so‐called Turbulent Kinetic Energy (TKE)‐l, or TKE‐l, parameterization of the diffusion coefficients for the representation of turbulent diffusion in neutral and stable conditions in large‐scale atmospheric models. The parameterization has been carefully designed to be completely tunable in the sense that all adjustable parameters have been clearly identified and the number of parameters has been minimized as much as possible to help the calibration and to thoroughly assess the parametric sensitivity. We choose a mixing length formulation that depends on both static stability and wind shear to cover the different regimes of stable boundary layers. We follow a heuristic approach for expressing the stability functions and turbulent Prandlt number in order to guarantee the versatility of the scheme and its applicability for planetary atmospheres composed of an ideal and perfect gas such as that of Earth and Mars. Particular attention has been paid to the numerical stability and convergence of the TKE equation at large time steps, an essential prerequisite for capturing stable boundary layers in General Circulation Models (GCMs). Tests, parametric sensitivity assessments and preliminary tuning are performed on single‐column idealized simulations of the weakly stable boundary layer. The robustness and versatility of the scheme are assessed through its implementation in the Laboratoire de Météorologie Dynamique Zoom GCM and the Mars Planetary Climate Model and by running simulations of the Antarctic and Martian nocturnal boundary layers.
Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca
Authors: Hamchand Randy , Wang Kevin , Song Deguang , Palm Noah W. , Crawford Jason M. 
Published: October 2024

AbstractVirulent Klebsiella oxytoca strains are associated with gut and lung pathologies, yet our understanding of the molecular signals governing pathogenesis remains limited. Here, we characterized a family of K. oxytoca pyrazine and pyrazinone autoinducers and explored their roles in microbial and host signaling. We identified the human mucin capping sugar Neu5Ac as a selective elicitor of leupeptin, a protease inhibitor prevalent in clinical lung isolates of K. oxytoca, and leupeptin-derived pyrazinone biosynthesis. Additionally, we uncovered a separate pyrazine pathway, regulated by general carbohydrate metabolism, derived from a broadly conserved PLP-dependent enzyme. While both pyrazine and pyrazinone signaling induce iron acquisition responses, including enterobactin biosynthesis, pyrazinone signaling enhances yersiniabactin virulence factor production and selectively activates the proinflammatory human histamine receptor H4 (HRH4). Our findings suggest that the availability of specific carbohydrates delineates distinct autoinducer pathways in K. oxytoca that may have differential effects on bacterial virulence and host immune responses.
A genome-first study of sex chromosome aneuploidies provides evidence of Y chromosome dosage effects on autism risk
Authors: Berry Alexander S. F. , Finucane Brenda M. , Myers Scott M. , Walsh Lauren K. , Seibert John M. , Martin Christa Lese , Ledbetter David H. , Oetjens Matthew T. 
Published: October 2024

AbstractA female protective effect has long been postulated as the primary explanation for the four-fold increase of autism spectrum disorder (ASD) diagnoses in males versus females. However, genetic and epidemiological investigations of this hypothesis have so far failed to explain the large difference in ASD prevalence between the sexes. To address this knowledge gap, we examined sex chromosome aneuploidy in a large ASD case-control cohort to evaluate the relationship between X and Y chromosome dosage and ASD risk. From these data, we modeled three relationships between sex chromosome dosage and ASD risk: the extra Y effect, the extra X effect, and sex chromosome haploinsufficiency. We found that the extra Y effect increased ASD risk significantly more than the extra X effect. Among females, we observed a large association between 45, X and ASD, confirming sex chromosome haploinsufficiency as a strong ASD risk factor. These results provide a framework for understanding the relationship between X and Y chromosome dosage on ASD, which may inform future research investigating genomic contributors to the observed sex difference.