bluuebunny/crossref_metadata_2025_split huggingface dataset:
New material of Ophisaurus, Anguis and Pseudopus (Squamata, Anguidae, Anguinae) from the Miocene of the Czech Republic and Germany and systematic revision and palaeobiogeography of the Cenozoic Anguinae
Authors: KLEMBARA JOZEF , RUMMEL MICHAEL 
Published: September 2016

AbstractFour species of Ophisaurus, O. fejfari, O. spinari, O. robustus and O. holeci, are recognized on the basis of parietals from the Early Miocene of the Czech Republic and Germany. The fifth species, O. acuminatus, is described from the Late Miocene of Germany, but its parietal is not preserved. This paper describes new O. fejfari, O. spinari, O. robustus and O. holeci specimens from the Early and Middle Miocene of the Czech Republic and Germany. The O. fejfari and O. holeci parietals from Germany are the first records of these species outside the Czech Republic. This paper provides a significant contribution to the understanding of both interspecific and intraspecific Ophisaurus variability in the Cenozoic of Europe. A well-preserved parietal of Anguis rarus sp. nov. is described from the Early Miocene of Germany. This is the first record of the parietal of Anguis in the Cenozoic. A new parietal from the Middle Miocene of Germany is described as Pseudopus sp. It differs from the contemporaneous P. laurillardi only in the absence of the large and distinctly laterally projecting anterolateral processes of the parietal. In the Miocene, Ophisaurus and Pseudopus exhibit a higher diversity than that of the preceding geological periods of the Cenozoic. Besides, Ophisaurus emigrates from Europe to (1) Asia and via the Bering Strait to North America, and (2) North Africa during the Oligocene and Miocene. By contrast, Anguis and Pseudopus are limited to Eurasia. The palaeobiogeography of members of Anguinae is discussed.
REAPPROPRIATION, RESISTANCE, AND BRITISH AUTOCRACY IN SRI LANKA, 1820–1850
Authors: WILSON JAMES 
Published: September 2016

AbstractSri Lanka's kingdom of Kandy fell to the British in 1815 and a rebellion in its name was defeated two years later. Across the next three decades, islanders took up religious ceremonies, legal concepts, and regal traditions formerly linked to Kandy's king and his court. These reappropriations were responses to efforts by the state to control Sri Lanka: expressions of kingship reassembled in particular ways to resist specific British incursions. Critically, islanders situated these activities in historical, colonial, and global contexts, manipulating transoceanic and imperial networks. Although they invariably failed, episodes of reappropriation bemused colonists with their complexities and globalisms and gradually subverted British autocracy, the form of imperial governance in Sri Lanka. Autocracy then gave way to more regularized modes of rule. Bringing together three separate examples, this article disputes an important argument about Sri Lanka's insurgent national character and reveals islanders’ elaborate responses to the incursions of imperialism. More broadly, it suggests that such episodes should be viewed as creative instances of resistance that deployed networks, practices, and ideas and became enmeshed with the development of the state through their influence over colonial governance. This locates aspects of imperial change within the Indian Ocean world.
THE FREEDOM OF THE PRESS IN JAMES MILL'S POLITICAL THOUGHT
Authors: GRINT KRIS 
Published: September 2016

ABSTRACTThis article examines the Scottish philosopher and historian James Mill's views on the freedom of the press, predominantly as they are expounded in his unpublished commonplace books, and argues that not only were these ideas very radical, they were critical to Mill's wider political thought and, by extension, to that of the early Philosophic Radicals. By virtue of the use of manuscript material, this article also presents evidence for various intellectual influences upon Mill, and argues that whilst Jeremy Bentham is of central importance to Mill's ideas, he takes inspiration from a wide range of other authors, both modern and ancient, in part as a way of normalizing his views in the context of the reactionary and conservative political climate that he was writing about them in: early nineteenth-century Britain.
A Dynamic Theory of Nuclear Proliferation and Preventive War
Authors: Bas Muhammet A. , Coe Andrew J. 
Published: September 2016

AbstractWe develop a formal model of bargaining between two states where one can invest in a program to develop nuclear weapons and the other imperfectly observes its efforts and progress over time. In the absence of a nonproliferation deal, the observing state watches the former's program, waiting until proliferation seems imminent to attack. Chance elements—when the program will make progress and when the other state will discover this—determine outcomes. Surprise proliferation, crises over the suspected progress of a nuclear program, and possibly “mistaken” preventive wars arise endogenously from these chance elements. Consistent with the model's predictions and contrary to previous studies, the empirical evidence shows that the progress of a nuclear program and intelligence estimates of it explain the character and outcomes of most interactions between a proliferant and a potential preventive attacker. Counterintuitively, policies intended to reduce proliferation by delaying nuclear programs or improving monitoring capabilities may instead encourage it.
Prospective associations between televiewing at toddlerhood and later self-reported social impairment at middle school in a Canadian longitudinal cohort born in 1997/1998
Authors: Pagani L. S. , Lévesque-Seck F. , Fitzpatrick C. 
Published: September 2016

BackgroundUsing a large Canadian population-based sample, this study aimed to verify whether televiewing in toddlerhood is prospectively associated with self-reported social impairment in middle school.MethodParticipants are from a prospective–longitudinal birth cohort of 991 girls and 1006 boys from the Quebec Longitudinal Study of Child Development. Child self-reported ratings of relational difficulties at age 13 years were linearly regressed on parent-reported televiewing at age 2 years while adjusting for potential confounders.ResultsEvery additional 1 h of early childhood television exposure corresponded to an 11%s.d.unit increase in self-reported peer victimization [unstandardizedβ= 0.03, 95% confidence interval (CI) 0.02–0.04], a 10%s.d.unit increase in self-reported social isolation (unstandardizedβ= 0.04, 95% CI 0.03–0.05), a 9%s.d.unit increase in self-reported proactive aggression (unstandardizedβ= 0.02, 95% CI 0.01–0.03) and a 6%s.d.unit increase in self-reported antisocial behavior (unstandardizedβ= 0.01, 95% CI 0.01–0.01) at age 13 years. These results are above and beyond pre-existing individual and family factors.ConclusionsTeleviewing in toddlerhood was prospectively associated with experiencing victimization and social withdrawal from fellow students and engaging in antisocial behavior and proactive aggression toward fellow students at age 13 years. Adolescents who experience relational difficulties are at risk of long-term health problems (like depression and cardiometabolic disease) and socio-economic problems (like underachievement and unemployment). These relationships, observed more than a decade later, and independent of key potential confounders, suggest a need for better parental awareness of how young children invest their limited waking hours.
DEGREE PROFILE OF HIERARCHICAL LATTICE NETWORKS
Authors: Feng Yarong , Mahmoud Hosam , Rüschendorf Ludger 
Published: September 2016

We study the degree profile of random hierarchical lattice networks. At every step, each edge is either serialized (with probability p) or parallelized (with probability 1−p). We establish an asymptotic Gaussian law for the number of nodes of outdegree 1, and show how to extend the derivations to encompass asymptotic limit laws for higher outdegrees. The asymptotic joint distribution of the number of nodes of outdegrees 1 and 2 is shown to be bivariate normal. No phase transition with p is detected in these asymptotic laws.For the limit laws, we use ideas from the contraction method. The recursive equations which we get involve coefficients and toll terms depending on the recursion variable and thus are not in the standard form of the contraction method. Yet, an adaptation of the contraction method goes through, showing that the method has promise for a wider range of random structures and algorithms.
Homotopical patch theory
Authors: ANGIULI CARLO , MOREHOUSE EDWARD , LICATA DANIEL R. , HARPER ROBERT 
Published: September 2016

AbstractHomotopy type theory is an extension of Martin-Löf type theory, based on a correspondence with homotopy theory and higher category theory. In homotopy type theory, the propositional equality type is proof-relevant, and corresponds to paths in a space. This allows for a new class of datatypes, called higher inductive types, which are specified by constructors not only for points but also for paths. In this paper, we consider a programming application of higher inductive types. Version control systems such as Darcs are based on the notion of patches—syntactic representations of edits to a repository. We show how patch theory can be developed in homotopy type theory. Our formulation separates formal theories of patches from their interpretation as edits to repositories. A patch theory is presented as a higher inductive type. Models of a patch theory are given by maps out of that type, which, being functors, automatically preserve the structure of patches. Several standard tools of homotopy theory come into play, demonstrating the use of these methods in a practical programming context.
A qualitative study of consumer perceptions and use of traffic light food labelling in Ecuador
Authors: Freire Wilma B , Waters William F , Rivas-Mariño Gabriela , Nguyen Tien , Rivas Patricio 
Published: September 2016

AbstractObjectiveTo analyse patterns of knowledge, comprehension, attitudes and practices regarding the traffic light label placed on processed food packages to inform Ecuadorian consumers about levels of added fat, sugar and salt.DesignTwenty-one focus group discussions organized by age group, sex and place of residence. Interviews with representatives of companies that manufacture or market processed foods. Analysis of regulations and structured observations of processed food labels.SettingCities and towns in Ecuador’s coastal, highland and eastern lowland regions.SubjectsOne hundred and seventy-eight participants in twenty-one focus group discussions and nine key informants.ResultsFocus group participants knew about the traffic light label and understood the information it conveys, but not all changed their attitudes and practices related to the purchase and consumption of processed foods. Children, adolescents and adult males reported using the information infrequently; adolescents interested in health and adult women used the label the most to select products. Representatives of companies that manufacture or market processed foods generally opposed the policy, stating that the information is misleading. Nevertheless, some companies have reduced levels of added fat, sugar or salt in their products.ConclusionsThe traffic light label is an effective tool for conveying complex information. Its potential contribution to reduce consumption of products with high levels of fat, sugar and salt could be enhanced by promoting healthy diets among consumers who have not changed purchasing and consumption behaviour, by placing the label on front panels and by monitoring the production and marketing of processed foods.
Focused X-Ray Histological Analyses to Reveal Asbestos Fibers and Bodies in Lungs and Pleura of Asbestos-Exposed Subjects
Authors: Pascolo Lorella , Gianoncelli Alessandra , Rizzardi Clara , de Jonge Martin , Howard Daryl , Paterson David , Cammisuli Francesca , Salomé Murielle , De Paoli Paolo , Melato Mauro , Canzonieri Vincenzo 
Published: September 2016

AbstractAsbestos bodies are the histological hallmarks of asbestos exposure. Both conventional and advanced techniques are used to evaluate abundance and composition in histological samples. We previously reported the possibility of using synchrotron X-ray fluorescence microscopy (XFM) for analyzing the chemical composition of asbestos bodies directly in lung tissue samples. Here we applied a high-performance synchrotron X-ray fluorescence (XRF) set-up that could allow new protocols for fast monitoring of the occurrence of asbestos bodies in large histological sections, improving investigation of the related chemical changes. A combination of synchrotron X-ray transmission and fluorescence microscopy techniques at different energies at three distinct synchrotrons was used to characterize asbestos in paraffinated lung tissues. The fast chemical imaging of the XFM beamline (Australian Synchrotron) demonstrates that asbestos bodies can be rapidly and efficiently identified as co-localization of high calcium and iron, the most abundant elements of these formations inside tissues (Fe up to 10% w/w; Ca up to 1%). By following iron presence, we were also able to hint at small asbestos fibers in pleural spaces. XRF at lower energy and at higher spatial resolution was afterwards performed to better define small fibers. These analyses may predispose for future protocols to be set with laboratory instruments.
Adolescent Antisocial Behavior Explained by Combining Stress-Related	Parameters
Authors: Platje Evelien , Jansen Lucres M. C. , Vermeiren Robert R. J. M. , Doreleijers Theo A. H. , van Lier Pol A. C. , Koot Hans M. , Meeus Wim H. J. , Branje Suzan J. T. , Popma Arne 
Published: September 2016

Abstract. Many stress-related parameters have been associated with antisocial behavior, including low cortisol awakening responses (CAR), as well as low cortisol and alpha-amylase reactivity to stress. These parameters reflect different, yet interrelated components of the stress system, yet it remains to be determined whether they exert joint or independent effects. Therefore, this study examined them in concert, as this may offer a better explanation of the psychophysiological mechanism’s underlying antisocial behavior. Antisocial behavior was assessed through self-report by 197 general population boys and girls (Mage = 17.31, SD = 0.44). The CAR was assessed, as well as cortisol and alpha-amylase reactivity to a public speaking task. Neither stress-related parameter was independently related to antisocial behavior. The best explanation was provided by a CAR × Cortisol reactivity interaction, indicating that in youth with a low CAR, antisocial behavior was positively associated with cortisol reactivity. In youth with a high CAR, no association between antisocial behavior and cortisol reactivity was found. Between cortisol and alpha-amylase reactivity a trend toward an interaction appeared, indicating a negative association between cortisol reactivity and antisocial behavior in those with low alpha-amylase reactivity, and a positive association in those with high alpha-amylase reactivity. These findings indicate that in order to understand the mechanisms underlying antisocial behavior, the stress system should be studied comprehensively rather than focus on single parameters. Particularly cortisol parameters appear to be jointly related to antisocial behavior, the additional value of alpha-amylase reactivity to cortisol reactivity may however be limited.
Vagally Mediated Heart Rate Variability Promotes the Perception of	Paradoxical Pain
Authors: Scheuren Raymonde , Sütterlin Stefan , Anton Fernand 
Published: September 2016

Abstract. Self-regulation mechanisms are governed by prefrontal inhibitory processes and play a crucial role in the modulation of pain. In the present study the thermal grill paradigm was used to investigate the association of vagally mediated resting heart rate variability, a psychophysiological marker of trait self-regulatory capacity, with paradoxical pain sensations induced by non-noxious stimulation. This thermal grill illusion is only perceived by part of the tested individuals. The mechanisms underlying the observed interindividual differences in paradoxical pain sensitivity are largely unknown. During the experimental task, a temperature combination of 15 °C and 41 °C was set at the glass tubes of the thermal grill. The 52 healthy participants placed their dominant hand on the grill for a duration of one min. The magnitude of sensory and affective pain sensations perceived during stimulation was assessed with numerical rating scales. Before stimulation, a short-term electrocardiogram was recorded to compute vagally mediated heart rate variability at rest. Logistic regression analyses revealed that participants with higher vagal tone were significantly more likely to perceive the thermal grill illusion than subjects displaying lower resting heart rate variability. Paradoxical pain sensations were primarily predicted by normalized respiratory sinus arrhythmia. Our results confirm that the magnitude of vagally mediated resting heart rate variability is associated with the individual disposition to illusive pain perceptions. Since the latter is considered to be a marker of trait self-regulation ability, the present findings may corroborate and complement previous evidence for an impact of psychological characteristics on paradoxical pain sensitivity.
Three-dimensional protonic conductivity in porous organic cage solids
Authors: Liu Ming , Chen Linjiang , Lewis Scott , Chong Samantha Y. , Little Marc A. , Hasell Tom , Aldous Iain M. , Brown Craig M. , Smith Martin W. , Morrison Carole A. , Hardwick Laurence J. , Cooper Andrew I. 
Published: September 2016

AbstractProton conduction is a fundamental process in biology and in devices such as proton exchange membrane fuel cells. To maximize proton conduction, three-dimensional conduction pathways are preferred over one-dimensional pathways, which prevent conduction in two dimensions. Many crystalline porous solids to date show one-dimensional proton conduction. Here we report porous molecular cages with proton conductivities (up to 10−3 S cm−1 at high relative humidity) that compete with extended metal-organic frameworks. The structure of the organic cage imposes a conduction pathway that is necessarily three-dimensional. The cage molecules also promote proton transfer by confining the water molecules while being sufficiently flexible to allow hydrogen bond reorganization. The proton conduction is explained at the molecular level through a combination of proton conductivity measurements, crystallography, molecular simulations and quasi-elastic neutron scattering. These results provide a starting point for high-temperature, anhydrous proton conductors through inclusion of guests other than water in the cage pores.
De novo sequencing, assembly and analysis of eight different transcriptomes from the Malayan pangolin
Authors: Mohamed Yusoff Aini , Tan Tze King , Hari Ranjeev , Koepfli Klaus-Peter , Wee Wei Yee , Antunes Agostinho , Sitam Frankie Thomas , Rovie-Ryan Jeffrine Japning , Karuppannan Kayal Vizi , Wong Guat Jah , Lipovich Leonard , Warren Wesley C. , O’Brien Stephen J. , Choo Siew Woh 
Published: September 2016

AbstractPangolins are scale-covered mammals, containing eight endangered species. Maintaining pangolins in captivity is a significant challenge, in part because little is known about their genetics. Here we provide the first large-scale sequencing of the critically endangered Manis javanica transcriptomes from eight different organs using Illumina HiSeq technology, yielding ~75 Giga bases and 89,754 unigenes. We found some unigenes involved in the insect hormone biosynthesis pathway and also 747 lipids metabolism-related unigenes that may be insightful to understand the lipid metabolism system in pangolins. Comparative analysis between M. javanica and other mammals revealed many pangolin-specific genes significantly over-represented in stress-related processes, cell proliferation and external stimulus, probably reflecting the traits and adaptations of the analyzed pregnant female M. javanica. Our study provides an invaluable resource for future functional works that may be highly relevant for the conservation of pangolins.
Platelets confound the measurement of extracellular miRNA in archived plasma
Authors: Mitchell Adam J. , Gray Warren D. , Hayek Salim S. , Ko Yi-An , Thomas Sheena , Rooney Kim , Awad Mosaab , Roback John D. , Quyyumi Arshed , Searles Charles D. 
Published: September 2016

AbstractExtracellular miRNAs are detectable in biofluids and represent a novel class of disease biomarker. Although many studies have utilized archived plasma for miRNA biomarker discovery, the effects of processing and storage have not been rigorously studied. Previous reports have suggested plasma samples are commonly contaminated by platelets, significantly confounding the measurement of extracellular miRNA, which was thought to be easily addressed by additional post-thaw plasma processing. In a case-control study of archived plasma, we noted a significant correlation between miRNA levels and platelet counts despite post-thaw processing. We thus examined the effects of a single freeze/thaw cycle on microparticles (MPs) and miRNA levels, and show that a single freeze/thaw cycle of plasma dramatically increases the number of platelet-derived MPs, contaminates the extracellular miRNA pool, and profoundly affects the levels of miRNAs detected. The measurement of extracellular miRNAs in archived samples is critically dependent on the removal of residual platelets prior to freezing plasma samples. Many previous clinical studies of extracellular miRNA in archived plasma should be interpreted with caution and future studies should avoid the effects of platelet contamination.
Regulation of Mitoflash Biogenesis and Signaling by Mitochondrial Dynamics
Authors: Li Wenwen , Sun Tao , Liu Beibei , Wu Di , Qi Wenfeng , Wang Xianhua , Ma Qi , Cheng Heping 
Published: September 2016

AbstractMitochondria are highly dynamic organelles undergoing constant network reorganization and exhibiting stochastic signaling events in the form of mitochondrial flashes (mitoflashes). Here we investigate whether and how mitochondrial network dynamics regulate mitoflash biogenesis and signaling. We found that mitoflash frequency was largely invariant when network fragmentized or redistributed in the absence of mitofusin (Mfn) 1, Mfn2, or Kif5b. However, Opa1 deficiency decreased spontaneous mitoflash frequency due to superimposing changes in respiratory function, whereas mitoflash response to non-metabolic stimulation was unchanged despite network fragmentation. In Drp1- or Mff-deficient cells whose mitochondria hyperfused into a single whole-cell reticulum, the frequency of mitoflashes of regular amplitude and duration was again unaltered, although brief and low-amplitude “miniflashes” emerged because of improved detection ability. As the network reorganized, however, the signal mass of mitoflash signaling was dynamically regulated in accordance with the degree of network connectivity. These findings demonstrate a novel functional role of mitochondrial network dynamics and uncover a magnitude- rather than frequency-modulatory mechanism in the regulation of mitoflash signaling. In addition, our data support a stochastic trigger model for the ignition of mitoflashes.