bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultraviolet cross‐linked ultra‐high molecular weight polyethylene fiber laminate: Preparation and mechanism analysis for its excellent mechanical properties
Authors: Dong Tianhong , Zhang Huiyuan , Zheng Cancan , Wang Xinpeng , Guo Jungu , Yan Cheng , Yan Tiantian , Wang Yimin , He Yong 
Published: October 2024

AbstractThe development of high‐performance ultra‐high molecular weight polyethylene (UHMWPE) fiber laminate is of great significance in the field of bulletproof materials. However, due to the poor heat resistance of UHMWPE fibers, it is challenging to achieve exceptional mechanical properties in laminates prepared via hot‐pressing. In this study, we employ a self‐made ultraviolet (UV) cross‐linked fully drawn yarn of UHMWPE (UVFDY), which exhibits excellent heat resistance, to prepare a UVFDY/unsaturated polyester resin (UPR) laminate through hot‐pressing. The laminate possesses outstanding mechanical properties, which includes high Barcol hardness (~40 HBa), high tensile strength (~800 MPa), and high storage modulus (~13.7 GPa at 25°C), surpassing those of most conventional UHMWPE fiber laminates. Its remarkable mechanical properties are primarily attributed to the highly cross‐linked networks of cured UPR and the stable structures (gel content ~89%, crystallinity ~81.5%, orientation ~93%, and smoother fiber surface) of UVFDY during hot‐pressing. This work not only provides valuable insights into the preparation of high‐performance UHMWPE fiber laminates but also promotes applications for the self‐made UV cross‐linked UHMWPE fiber.Highlights
Novel laminate possesses high Barcol hardness.
The tensile strength and storage modulus of novel laminate are excellent.
UV irradiated fiber with high structural stability during hot‐pressing.
Prenatal Ultrasonographic Features Associated With ARSL and X‐Linked Chondrodysplasia Punctata 1 (CDPX1): Literature Review and Case Series
Authors: Broeren Eleanor , Stover Samantha , Bennett Katya , Giordano Jessica , Galloway Stephanie , Lauzon Julie , Rust Laura , Suerink Manon , van Haeringen Arie ,   Australian Genomic Autopsy Study Team, Reimers Rebecca 
Published: October 2024

ABSTRACTBackgroundChondrodysplasia punctata 1 (CDPX1) is an X‐linked recessive disorder of cartilage and bone development characterized by stippling on the cartilage and bone, flattened nasal bridge, and brachydactyly, or short fingers. CDPX1 has been associated with variants in the ARSL gene and is known to manifest prenatally, however, there has been no systematic literature review on this evidence.AimsHere, we reviewed the current literature on prenatal manifestations of CDPX1, and additionally introduce previously unpublished cases.Materials & MethodsA systematic review of the literature was performed. Additionally, a GeneMatcher submission was created and a call for cases was presented at the Fetal Sequencing Consortium meetings to find previously unpublished cases.ResultsFor the 22 fetuses reported here, we found that 55% had nasal hypoplasia, 41% had bony stippling or calcifications, 32% had polyhydramnios, 5% had oligohydramnios, 23% had shortened long bones, 23% had spinal canal stenosis, 18% had ventriculomegaly, 9% had brachydactyly/brachytelephalangy, 9% had clubbed feet, 9% had premature rupture of membranes, and 9% had intraventricular hemorrhage detected through sonography or radiography. We also found 17 unique variants in ARSL for these 22 fetuses.DiscussionA previously unpublished association of ARSL variants with intrauterine fetal death or stillbirth has been noted in this study. It is also possible that intracranial hemorrhage is an underrecognized feature associated with CDPX1 variation. However, there have been challenges in applying ACMG criteria to ARSL, a gene without an associated Variant Curation Expert Panel.ConclusionThis literature review and case series highlights which features of CDPX1 manifest prenatally, as well as introduces new phenotypes that have not been previously identified.
Validation Assessment of Privacy‐Preserving Synthetic Electronic Health Record Data: Comparison of Original Versus Synthetic Data on Real‐World COVID‐19 Vaccine Effectiveness
Authors: Wang Echo , Mott Katrina , Zhang Hongtao , Gazit Sivan , Chodick Gabriel , Burcu Mehmet 
Published: October 2024

ABSTRACTPurposeTo assess the validity of privacy‐preserving synthetic data by comparing results from synthetic versus original EHR data analysis.MethodsA published retrospective cohort study on real‐world effectiveness of COVID‐19 vaccines by Maccabi Healthcare Services in Israel was replicated using synthetic data generated from the same source, and the results were compared between synthetic versus original datasets. The endpoints included COVID‐19 infection, symptomatic COVID‐19 infection and hospitalization due to infection and were also assessed in several demographic and clinical subgroups. In comparing synthetic versus original data estimates, several metrices were utilized: standardized mean differences (SMD), decision agreement, estimate agreement, confidence interval overlap, and Wald test. Synthetic data were generated five times to assess the stability of results.ResultsThe distribution of demographic and clinical characteristics demonstrated very small difference (< 0.01 SMD). In the comparison of vaccine effectiveness assessed in relative risk reduction between synthetic versus original data, there was a 100% decision agreement, 100% estimate agreement, and a high level of confidence interval overlap (88.7%–99.7%) in all five replicates across all subgroups. Similar findings were achieved in the assessment of vaccine effectiveness against symptomatic COVID‐19 Infection. In the comparison of hazard ratios for COVID 19‐related hospitalization and odds ratio for symptomatic COVID‐19 Infection, the Wald tests suggested no significant difference between respective effect estimates in all five replicates for all patient subgroups but there were disagreements in estimate and decision metrices in some subgroups and replicates.ConclusionsOverall, comparison of synthetic versus original real‐world data demonstrated good validity and reliability. Transparency on the process to generate high fidelity synthetic data and assurances of patient privacy are warranted.
Agreement of Medication Information Derived From EHR Data Compared to Medicare Insurance Claims: An Analysis of Biologic Disease‐Modifying Antirheumatic Drugs
Authors: Li Jing , Baker Rahaf , Stovall Rachael , Curtis Jeffrey R. , Xie Fenglong , Yazdany Jinoos , Schmajuk Gabriela 
Published: October 2024

ABSTRACTPurposeFew studies have reported the agreement between medication information derived from ambulatory EHR data compared to administrative claims for high‐cost specialty drugs. We used data from a national EHR‐enabled registry, the Rheumatology Informatics System for Effectiveness (RISE), with linked Medicare claims in a population of patients with rheumatoid arthritis (RA) to investigate variations in agreement for different biologic disease‐modifying agents (bDMARDs) between two data sources (RISE EHR data vs. Medicare claims), categorized by drug, route of administration, and patient insurance factors (dual eligibility).MethodsPatients ≥ 65 years old, with ≥ 2 visits in RISE with RA ICD codes ≥ 30 days apart, and continuous enrollment in Medicare Parts B and D in 2017–2018 were included. We classified patients as bDMARD users or nonusers in Medicare claims or EHR data in 2018, and we calculated sensitivity, specificity, positive predicted value (PPV), and negative predicted value (NPV) of EHR data for identifying bDMARD users, using Medicare as the reference standard. We also calculated these metrics after stratifying by clinic‐administered (Part B) versus. pharmacy‐dispensed (Part D) bDMARDs and by patient dual‐eligibility.ResultsA total of 26 097 patients were included in the study. Using Medicare claims as the reference standard, EHR data had a sensitivity of 75.0%–90.8% for identifying patients with the same medication and route. PPV for Part B bDMARDs was higher compared with Part D bDMARDs (range 94.3%–97.3% vs. 51.0%–69.6%). We observed higher PPVs for Part D bDMARDs among patients who were dual‐eligible (range 82.4%–95.1%).ConclusionThe risk of misclassification of drug exposure based on EHR data sources alone is small for Medicare Part B bDMARDs but could be as high as 50% for Part D bDMARDs, in particular for patients who are not dually eligible for Medicare and Medicaid.
Real‐World Assessment of Psychotropic and Antiepileptic Drug Use During Pregnancy in Belgium: Trends, Predictors, and Comparative Risk of Congenital Anomalies (2010–2016)
Authors: Larcin Lionel , Ngwasiri Calypse , Neven Anouk , Damase‐Michel Christine , Kirakoya‐Samadoulougou Fati 
Published: October 2024

ABSTRACTPurposeTo analyze the prescription patterns and sociodemographic factors associated with the use of antipsychotic, antidepressant, and antiepileptic drugs during pregnancy in Belgium, and to investigate their potential association with congenital anomalies.MethodsUsing a nationwide linked database, we identified antidepressants, antipsychotics, and antiepileptics via the Anatomical Therapeutic and Chemical Classification (ATC) codes. For each medication group, we calculated the overall prevalence and prevalence for the three most used medications at the fifth ATC level. Sociodemographic factors influencing medication use during pregnancy were analyzed, and potential associations with congenital anomalies were investigated through logistic regression models based on generalized estimating equations.ResultsOverall, 828 016 live births pregnancies associated with 611 094 mothers were identified. We found that the use of antidepressants, antipsychotics, and antiepileptics was decreasing with the arrival of pregnancy. Mothers with a less favorable sociodemographic status were more likely to be exposed to these medications. Antiepileptics used in the first trimester were associated with an increased risk of congenital anomalies (aOR = 1.65, 95% CI 1.11–2.45) compared with unexposed women. The three most used antiepileptics were lamotrigine, valproate, and levetiracetam, among them, we found an association with congenital anomalies only for valproate (aOR = 3.92, 95% CI 2.30–6.67).ConclusionsPsychotropic and antiepileptic drug use decreased during pregnancy. Pregnant women with a less favorable sociodemographic status were more likely to be exposed to psychotropics and antiepileptics during pregnancy. The elevated risk of congenital anomalies associated with antiepileptics use, particularly valproate, underscores the need for targeted interventions and increased awareness to improve maternal and fetal health outcomes.
The Characteristics Analysis of Hyaluronic Acid Modified By Cold Atmospheric Plasma and Its Performance in Hydrogel Preparation
Authors: Xu Tian‐ao , Wang Xiao‐Long , Li Lian , Luo Jun‐Sha , Ding Yun‐Han , Zhao Tong , Liu Ya‐Di , Sun Ying , Zhang Yuan‐Tao 
Published: October 2024

ABSTRACTHyaluronic acid (HA) is extensively utilized in biomedical applications, and its functionality can be enhanced by introducing aldehyde groups (─CHO) through oxidation. In this study, cold atmospheric plasma (CAP) was used to treat aqueous HA solutions, resulting in the formation of plasma‐modified HA (PMHA) containing ─CHO groups. The free radicals generated from interactions between water molecules and CAP particles reacted with HA, leading to the oxidation of hydroxyl groups into ─CHO and the cleavage of glycosidic bonds, causing molecular depolymerization. The PMHA was then used to synthesize hydrogels in combination with carboxymethyl chitosan and ɛ‐polylysine. This study presents an effective approach for generating HA with aldehyde functionalities and offers insights into the interaction between CAP and polysaccharides.
TMT‐Based Quantitative Proteomic Profiling of Human Esophageal Cancer Cells Reveals the Potential Mechanism and Potential Therapeutic Targets Associated With Radioresistance
Authors: Gao Aidi , He Chao , Chen Hengrui , Liu Qianlin , Chen Yin , Sun Jianying , Wu Chuanfeng , Pan Ya , Rocha Sonia , Wang Mu , Zhou Jundong 
Published: October 2024

ABSTRACTPurposeThe recurrence of esophageal squamous cell carcinoma (ESCC) in radiation therapy treatment presents a complex challenge due to its resistance to radiation. However, the mechanism underlying the development of radioresistance in ESCC remains unclear. In this study, we aim to uncover the mechanisms underlying radioresistance in ESCC cells and identify potential targets for radiosensitization.MethodsWe established two radio‐resistant cell lines, TE‐1R and KYSE‐150R, from the parental ESCC cell lines TE‐1 and KYSE‐150 through fractionated irradiation. A TMT‐based quantitative proteomic profiling approach was applied to identify changes in protein expression patterns. Cell Counting Kit‐8, colony formation, γH2AX foci immunofluorescence and comet assays were utilized to validate our findings. The downstream effectors of the DNA repair pathway were confirmed using an HR/NHEJ reporter assay and Western blot analysis. Furthermore, we evaluated the expression of potential targets in ESCC tissues through immunohistochemistry combined with mass spectrometry.ResultsOver 2,000 proteins were quantitatively identified in the ESCC cell lysates. A comparison with radio‐sensitive cells revealed 61 up‐regulated and 14 down‐regulated proteins in the radio‐resistant cells. Additionally, radiation treatment induced 24 up‐regulated and 12 down‐regulated proteins in the radio‐sensitive ESCC cells. Among the differentially expressed proteins, S100 calcium binding protein A6 (S100A6), glutamine gamma‐glutamyltransferase 2 (TGM2), glycogen phosphorylase, brain form (PYGB), and Thymosin Beta 10 (TMSB10) were selected for further validation studies as they were found to be over‐expressed in the accumulated radio‐resistant ESCC cells and radio‐resistant cells. Importantly, high S100A6 expression showed a positive correlation with cancer recurrence in ESCC patients. Our results suggest that several key proteins, including S100A6, TGM2, and PYGB, play a role in the development of radioresistance in ESCC.ConclusionsOur results revealed that several proteins including Protein S100‐A6 (S100A6), Protein‐glutamine gamma‐glutamyltransferase 2 (TGM2), Glycogen phosphorylase, brain form (PYGB) were involved in radio‐resistance development. These proteins could potentially serve as biomarkers for ESCC radio‐resistance and as therapeutic targets to treat radio‐resistant ESCC cells.
Determining selectivity of isocycloseram and afidopyropen and their compatibility with conservation biological control in Arizona cotton
Authors: Bordini Isadora , Naranjo Steven E. , Fournier Alfred , Ellsworth Peter C. 
Published: October 2024

AbstractBACKGROUNDSelective tools, including selective insecticides and transgenic cotton, have been crucial in reducing insecticide usage within the integrated pest management (IPM) plan for Arizona cotton. To guide growers effectively, cotton field trials evaluated the effects of the novel insecticides, isocycloseram and afidopyropen against our primary pests, Bemisia argentifolii and Lygus hesperus, and their impacts on nontarget arthropods, including key predators: Collops spp., Orius tristicolor, Geocoris spp., Misumenops celer, Drapetis nr. divergens and Chrysoperla carnea s.l. Assessments involved over 27 arthropod taxa through community analyses, individual predator abundance, and biological control function via predator to prey ratios and a sentinel prey method. Comparisons were made with an untreated check, a proven fully selective insecticide (flonicamid) and acephate‐treated positive controls.RESULTSOverall, relative to the untreated check, afidopyropen showed no significant differences, whereas isocycloseram exhibited some negative impacts, primarily reducing M. celer and Geocoris spp. nymphs, yet it was less detrimental compared with the positive control, acephate, and it did not affect four of the six key predators and most nontarget arthropods.CONCLUSIONAfidopyropen was classified as a fully selective insecticide and isocycloseram as a partially selective insecticide. Their fit for conservation biological control in Arizona cotton IPM and similar systems is discussed. © 2024 Society of Chemical Industry.
Tropospheric amplification of stratosphere–troposphere coupling
Authors: Baldwin Mark P. , Birner Thomas , Ayarzagüena Blanca 
Published: October 2024

AbstractDuring northern winter the stratospheric polar vortex is highly variable — even breaking down completely during sudden stratospheric warmings. The strength of the stratospheric polar vortex is observed to be coupled to surface weather, primarily through swings in the phase of the Northern Annular Mode — which is nearly uuivalent to polar‐cap sea‐level pressure. Pressure changes (as a function of height) are largest at the surface, which is difficult to reconcile with the remote effects of stratospheric variability. This conundrum requires some mechanism(s) to amplify the polar sea‐level pressure anomalies. A simple, intuitive explanation has remained elusive. We use Japanese 55‐year Reanalysis (JRA‐55) reanalyses to investigate the reason that stratospheric variability causes large polar sea‐level pressure changes. The main result of this paper is that vertical movement of the polar tropopause is essential in understanding how surface pressure changes are generated. The strength of the polar vortex is strongly coupled to the height of the polar tropopause, resulting in stretching/compression of the polar tropospheric air column. This causes pressure changes that are largest at the surface. For example, the lowering of the polar tropopause during a sudden stratospheric warming leads to a compression and spin down of the tropospheric column and is therefore associated with higher polar sea‐level pressure. This mechanism can be compared to the textbook example of conservation of potential vorticity as an air column moves over a mountain range — except in this case the column depth changes because the stratosphere is changing the height of the tropopause. The observed vertical profile of pressure changes matches closely what would be expected from the stretching/compression mechanism. The higher polar sea‐level pressure associated with a sudden stratospheric warming is due mainly to mass moving into the polar cap within the troposphere, rather than rearranged mass in the stratosphere.
An artificial neural network approach for out‐of‐control stream identification in multiple stream processes
Authors: Lepore Antonio , Palumbo Biagio , Sposito Gianluca 
Published: October 2024

AbstractA multiple stream process (MSP) is a process at a point in time that generates several streams of output with quality variables and specifications that are identical in all streams. Statistical process control (SPC) schemes for MSPs are designed to issue an out‐of‐control (OC) signal when a possible change occurs from the in‐control (IC) state of the process. However, the SPM literature for MSPs lacks contributions regarding post‐hoc identification of the stream or group of streams responsible for an OC signal. In this article, we propose an artificial neural network (NN) specifically trained for this purpose and, through a Monte Carlo simulation, show its superiority in correctly identifying OC streams, since an OC signal has been correctly issued. The research is motivated by the need for a post hoc diagnosis of the heating, ventilation, and air conditioning (HVAC) systems installed on modern train coaches, generating multiple streams of quality variables of interest. A case study in this area based on the HVAC data (openly available online at https://github.com/unina‐sfere/NN4OCMSP) illustrates the practical applicability of the proposed approach, which is implemented in the Python package NN4OCMSP and published on the PyPI software repository.
Device‐Independent Dimension Leakage Null Test on Qubits at Low Operational Cost
Authors: Rybotycki Tomasz , Białecki Tomasz , Batle Josep , Bednorz Adam 
Published: October 2024

AbstractA null test of the two‐level space of a qubit is constructed, which is both device independent and needs a small number of different experiments. Its feasibility is demonstrated on IBM Quantum, with most qubits failing the test by more than ten standard deviations. The robustness of the test against common technical imperfections, like decoherence and phase shifts, and supposedly negligible leakage, indicates that the origin of deviations is beyond known effects.
Highly Efficient Catalysis of Pyridinium p‐Toluenesulfonate (PPTS): Two Facile One‐Pot Protocols for the Synthesis of 2,3‐Disubstituted Quinazolinone Scaffolds
Authors: Chiranjeevi Yakkanti , Rao Lakinani Vaikunta , Raghunadh Akula , Satyender Apuri 
Published: October 2024

AbstractTwo different one‐pot synthetic protocols have been developed for obtaining 2,3‐disubstituted quinazolin‐4(3H)‐ones using pyridinium p‐toluenesulfonate (PPTS) as catalyst. The two‐component reaction involves isatoic anhydride and N‐acetyl amine whereas the three‐component reaction use isatoic anhydride, aryl amine and β‐diketone in Toluene under classical heating at 80–100 °C to afford 2,3‐disubstituted quinazolin‐4(3H)‐ones in good yields. The two‐component reactions are compatible with various substituted aryl/alkyl amines.
Computational Evaluation of Bioactive Compounds in Vernonia Amygdalina as a Novel Therapeutics for Acute Myeloid Leukemia: Targeting the Hedgehog Pathway
Authors: Oluwatosin Maryam Adeyemo , Barakat Olamide Ishola , Salihaat Toyin Okunola , Gervacio‐Villarreal Edinson Alfonzo , Ropón‐Palacios Georcki , Busayo Olowosoke Christopher , Naeem Abdulsalam Zainab , Adebayo Abdulqohar , Bin Jardan Yousef A. , Metouekel Amira , Bourhia Mohammed , Mohammad Salamatullah Ahmad , Isiyaku Umar Haruna 
Published: October 2024

AbstractThe drug resistance challenges in acute myeloid leukemia have been linked the hedgehog (HH) signaling pathway activation by many studies. Furthermore, studies have shown that the components of the HH pathway, including 12‐pass transmembrane receptor Patched (PTCH), the 7‐pass transmembrane signal transduction protein Smoothened (SMO), and all three GLI transcription factors, are expressed in AML. Thus, pharmacological inhibition of SMO in the HH signaling in these cells has anti‐leukemic effects. However, the first SMO inhibitor specific to AML (Glasdegib) has been approved based on improved overall survival rates, but alternative approaches are still required. Thus we employed druglikeness screening, molecular docking, molecular dynamics simulation, non‐equilibrium free energy and in silico pharmacokinetics profiling on bioactive compounds from Vernonia amygdalina against SMO protein target. From 30 bioactive compounds in V. amygdalina, 13 had drug‐like potential, 5 had binding energy between −9.2 to −9.9 kcal/mol. Cryptolepine, neocryptolepine and isocryptolepine with the least BE showed good stability, dynamics over 300 ns of MD run and higher binding affinities via the Jarzynski's identity. Hence, these bioactive compounds may serve as potential drugs for the treatment of acute myeloid leukemia by targeting the SMO protein after wet lab experiments.