bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Perioperative Management of Anomalous Aortic Origin of a Coronary Artery Between an Adult and Pediatric Cardiac Center
Authors: Herrmann Jeremy L. , Goldberg Leah A. , Khan Abigail M. , Partington Sara L. , Brothers Julie A. , Mascio Christopher E. , Spray Thomas L. , Kim Yuli Y. , Fuller Stephanie 
Published: November 2016

Background: Anomalous aortic origin of a coronary artery (AAOCA) presents in varying age-groups. Assuming management algorithms differ between pediatric and adult institutions, we compared the perioperative management of patients with AAOCA at two such centers. Methods: A retrospective review was conducted at a pediatric and an adult institution of patients 14 years or older who underwent surgical repair of AAOCA between January 2000 and May 2014. Results: Twenty patients from the pediatric center (median age: 16.5 years, range: 14-18 years) and nine patients from the adult center (median age: 40 years, range: 37-52 years) were included. An anomalous aortic origin of a right coronary artery was the most frequent pathology at each institution. Chest pain was the most common presenting symptom at both institutions. Preoperative echocardiography was performed in 95% patients at the pediatric center and in 100% of patients at the adult center. Cardiac catheterization was utilized more frequently at the adult center, and cardiac magnetic resonance imaging more commonly employed at the pediatric center. Isolated coronary unroofing was performed in 19 of 20 cases at the pediatric center and in only 2 (22%) cases at the adult institution, both by congenitally trained cardiac surgeons. More concomitant cardiac procedures were performed at the adult center with associated longer operative times and hospital stays. Conclusion: Management strategies for AAOCA vary depending on both patient-specific factors and expertise of the managing team. Further studies are needed to optimally standardize diagnostic and treatment pathways regardless of location venue.
Do Clinical Results and Return-to-Sport Rates After Ulnar Collateral Ligament Reconstruction Differ Based on Graft Choice and Surgical Technique?
Authors: Erickson Brandon J. , Cvetanovich Gregory L. , Frank Rachel M. , Bach Bernard R. , Cohen Mark S. , Bush-Joseph Charles A. , Cole Brian J. , Romeo Anthony A. 
Published: November 2016

Background: Ulnar collateral ligament reconstruction (UCLR) has become a common procedure performed in overhead-throwing athletes of many athletic levels. Purpose/Hypothesis: The purpose of this study was to determine whether clinical outcomes and return-to-sport (RTS) rates differ among patients undergoing UCLR based on graft choice, surgical technique, athletic competition level, handedness, and treatment of the ulnar nerve. We hypothesized that no differences would exist in clinical outcomes or RTS rates between technique, graft choice, or other variables. Study Design: Cohort study; Level of evidence, 3. Methods: All patients who underwent UCLR from January 1, 2004 through December 31, 2014 at a single institution were identified. Charts were reviewed to determine patient age, sex, date of surgery, sport played, handedness, athletic level, surgical technique, graft type, and complications. Patients were contacted via telephone to obtain the RTS rate, Conway-Jobe score, Timmerman-Andrews score, and Kerlan-Jobe Orthopaedic Clinic (KJOC) Shoulder and Elbow score. Results: Eighty-five patients (mean age at surgery, 19.3 ± 4.7 years; 92% male; 78% right hand–dominant) underwent UCLR between 2004 and 2014 and were available for follow-up. Overall, 87% were baseball pitchers, 49.4% were college athletes, and 41.2% were high school athletes. No significant difference existed between the docking and double-docking techniques, graft choice, handedness, sex, activity level, and treatment of the ulnar nerve with regard to clinical outcomes, RTS, or subsequent surgeries (all P > .05). More complications were seen in the docking technique compared with the double-docking technique ( P = .036). Hamstring autograft was used more commonly with the docking technique ( P = .023) while allograft was used more commonly with the double-docking technique ( P = .0006). Conclusion: Both the docking and double-docking techniques produce excellent clinical outcomes in patients undergoing UCLR. No difference in outcome scores was seen between surgical technique or graft type. The double-docking technique had fewer complications than the docking technique.
DASP3: identification of protein sequences belonging to functionally relevant groups
Authors: Leuthaeuser Janelle B. , Morris John H. , Harper Angela F. , Ferrin Thomas E. , Babbitt Patricia C. , Fetrow Jacquelyn S. 
Published: November 2016

Abstract
Background
Development of automatable processes for clustering proteins into functionally relevant groups is a critical hurdle as an increasing number of sequences are deposited into databases. Experimental function determination is exceptionally time-consuming and can’t keep pace with the identification of protein sequences. A tool, DASP (Deacon Active Site Profiler), was previously developed to identify protein sequences with active site similarity to a query set. Development of two iterative, automatable methods for clustering proteins into functionally relevant groups exposed algorithmic limitations to DASP.

Results
The accuracy and efficiency of DASP was significantly improved through six algorithmic enhancements implemented in two stages: DASP2 and DASP3. Validation demonstrated DASP3 provides greater score separation between true positives and false positives than earlier versions. In addition, DASP3 shows similar performance to previous versions in clustering protein structures into isofunctional groups (validated against manual curation), but DASP3 gathers and clusters protein sequences into isofunctional groups more efficiently than DASP and DASP2.

Conclusions
DASP algorithmic enhancements resulted in improved efficiency and accuracy of identifying proteins that contain active site features similar to those of the query set. These enhancements provide incremental improvement in structure database searches and initial sequence database searches; however, the enhancements show significant improvement in iterative sequence searches, suggesting DASP3 is an appropriate tool for the iterative processes required for clustering proteins into isofunctional groups.
RETRACTED ARTICLE: Regulatory effects of glycyrrhizae radix extract on DSS-induced ulcerative colitis
Authors: Jeon Yong-Deok , Bang Keuk-Soo , Shin Min-Kyoung , Lee Jong-Hyun , Chang Young-Nam , Jin Jong-Sik 
Published: November 2016

Abstract
Background
Glycyrrhizae Radix (GR) is a Korean traditional herb medicine that is widely-used in clinical health care. The clinical functions of GR include relief of toxicity, anti-cancer, regulating blood cholesterol and anti-inflammation. This study investigated the role of GR on ulcerative colitis in a dextran sulfate sodium (DSS)-induced mouse model of colitis.

Method
Western blot analysis and enzyme-linked immunosorbent assay (ELISA) analyses were done on male BALB/c mice administered 5 % DSS during the experimental period. Ethanol extracts of GR were orally administered at same time daily to control mice. The severity of colitis was measured by body weight change and colon length.

Result
DSS-treated mice displayed weight loss and shortened colon length compared with control mice. Mice were administered GR showed less weight loss and longer colon length than the DSS-treated group. Inflammatory cytokines were decreased by GR treatment. Treatment also reduced DSS-induced microscopic damage to colon tissue. GR regulated the phosphorylation of transcription factors such as NF-κB p65 and IκB α.

Conclusions
GR has beneficial effects in a colitis model. GR might be a useful herb medicine in the treatment of ulcerative colitis.
Linked Forests: Semantic similarity of geographical concepts “forest”
Authors: Čerba Otakar , Jedlička Karel 
Published: November 2016

AbstractLinked Data represents the new trend in geoinformatics and geomatics. It produces a structure of objects (in a form of concepts or terms) interconnected by object relations expressing a type of semantic relationships of various concepts. The research published in this article studies, if objects connected by above mentioned relations are more similar than objects representing the same phenomenon, but standing alone. The phenomenon “forest” and relevant geographical concepts were chosen as the domain of the research. The concepts similarity (Tanimoto coefficient as a specification of Tversky index) was computed on the basis of explicit information provided by thesauri containing particular concepts. Overall in the seven thesauri (AGROVOC, EuroVoc, GEMET, LusTRE/EARTh, NAL, OECD and STW) there was tested if the “forest” concept interconnected by the relation skos:exactMatch are more similar than other, not interlinked concepts. The results of the research are important for the sharing and combining of geographical data, information and knowledge. The proposed methodology can be reused to a comparison of other geographical concepts.
An S-type upper bound for the largest singular value of nonnegative rectangular tensors
Authors: Zhao Jianxing , Sang Caili 
Published: November 2016

Abstract
An S-type upper bound for the largest singular value of a nonnegative rectangular tensor is given by breaking N = {1, 2, … n} into disjoint subsets S and its complement. It is shown that the new upper bound is smaller than that provided by Yang and Yang (2011). Numerical examples are given to verify the theoretical results.
Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors
Authors: Rosenberg Nadia , Gerber Urs , Ster Jeanne 
Published: November 2016

It is well established that selective activation of group I metabotropic glutamate (mGlu) receptors induces LTD of synaptic transmission at Schaffer collateral–CA1 synapses. In contrast, application of 1S,3R-ACPD, a mixed agonist at group I and group II mGlu receptors, induces LTP. Using whole-cell recordings from CA1 pyramidal cells and field recordings in the hippocampal CA1 region, we investigated the specific contribution of group II mGlu receptors to synaptic plasticity at Schaffer collateral–CA1 synapses in acute slices of adult mice. Pharmacological activation of group II mGlu receptors (mGlu2 and mGlu3 receptors) with the specific agonist LY354740 in conjunction with electrical stimulation induced postsynaptic LTP. This form of plasticity requires coactivation of NMDA receptors (NMDARs). Group II mGlu receptor activation led to PKC-dependent phosphorylation of the GluN1 subunit. We found that both synaptic and extrasynaptic NMDARs, which are differentially modulated by mGlu2 and mGlu3 receptors, contribute to LTP induction. Furthermore, LTP initiated by activation of group II mGlu receptors was not occluded by LTP induced with high-frequency trains of stimuli. However, the phosphorylation of NMDARs mediated by group II mGlu receptor activation led to a priming effect that enhanced subsequent high-frequency stimulation-induced LTP. These findings reveal a novel metaplastic mechanism through which group II mGlu receptors modulate synaptic function at the Schaffer collateral input to CA1 pyramidal cells, thereby lowering the threshold to induce plasticity.SIGNIFICANCE STATEMENTThe group II metabotropic glutamate (mGlu II) receptors exert a well characterized action on presynaptic neuron terminals to modulate neurotransmitter release. Here, we show that these receptors also have postsynaptic effects in promoting the induction of synaptic plasticity. Using an electrophysiological approach including field and whole-cell patch recording in hippocampi from wild-type and transgenic mice, we show that activation of group II mGlu receptors enhances NMDA receptor (NMDAR)-mediated currents through PKC-dependent phosphorylation. This priming of NMDARs lowers the threshold for the induction of LTP of synaptic transmission. These findings may also provide new insights into the mechanisms through which drugs targeting mGlu II receptors alleviate hypoglutamatergic conditions such as those occurring in certain brain disorders such as schizophrenia.
STATUS KESEHATAN IKAN SIDAT (Anguilla sp.) PADA PERAIRAN UMUM DAN WADAH PEMELIHARAAN SEMENTARA
Authors: Setyawan Agung Cahyo , Sukenda Sukenda , Nuryati Sri 
Published: November 2016

Status kesehatan ikan sidat (Anguilla sp.) telah dianalisis untuk menunjukkan terjadinya penurunan stok karena infeksi patogen dan penangkapan benih berlebihan untuk budidaya. Di Indonesia, ketiadaan standar penangkapan, pemeliharaan dan budidaya menyebabkan terjadinya penurunan kualitas dan kuantitas produksi ikan sidat. Penelitian ini dilakukan untuk mengevaluasi status kesehatan ikan sidat di perairan Indonesia dengan sampel dari Kabupaten Banyumas dan Cilacap, Jawa Tengah. Sampling dilakukan pada awal musim penghujan, yaitu bulan September hingga November 2012. Sebanyak 113 ekor ikan sidat ditangkap dan dianalisis dalam penelitian ini, dengan perincian 57 ekor diamati langsung setelah ditangkap dan 56 ekor diamati setelah dipelihara selama 10 hari oleh pengepul. Pengamatan dilakukan dengan metode observasi langsung menggunakan mikroskop untuk parasit, kit API 20NE (Biomeureux®) untuk bakteri dan pewarnaan standar haematoxylin-eosin untuk histopatologi. Terdapat empat jenis parasit (Nematoda: Camallanidae dan Anguillicoloides; Platyhelminthes: Monogenea dan Digenea) dan lima bakteri (Aeromonas hydrophylla, Pseudomonas luteola, Vibrio fluvialis, Aeromonas sobria, dan Aeromonas caviae) dari sampel ikan sidat dalam penelitian ini. Tidak terdapat perbedaan dalam komposisi patogen, namun terjadi perubahan dalam kondisi histopatologi sehingga pemeliharaan sementara oleh pengepul sebelum ikan sidat dibudidayakan memiliki potensi menurunkan kualitas benih untuk budidaya.
HERBAL MANGROVE SEBAGAI SUMBER ANTI BAKTERI Vibrio harveyi PENYEBAB PENYAKIT PADA UDANG WINDU Penaeus monodon
Authors: Muliani Muliani , Nurhidayah Nurhidayah , Kurniawan Koko 
Published: November 2016

Penelitian ini bertujuan untuk mendapatkan herbal tanaman mangrove sebagai sumber antibakteri V. harveyi penyebab penyakit pada udang windu Penaeus monodon. Penelitian dilakukan di Balai Penelitian dan Pengembangan Budidaya Air Payau (BPPBAP), Maros. Mangrove diambil dari lima lokasi yaitu: Kabupaten Maros, Pangkep, Luwu Timur, Takalar, dan Bone. Mangrove yang dikumpulkan diidentifikasi sebelum dikering-anginkan selama dua minggu. Setelah kering dibuat tepung dan diekstrak menggunakan pelarutorganik (metanol). Ekstrak metanol dari herbal mangrove diuji bioassay secara kualitatif dan kuantitatif untuk mengetahui aktivitas anti V. harveyi menggunakan metode mikrowell plate. Setelah itu, dilakukan uji tantang secara in vitro dengan V. harveyi pada konsentrasi yang berbeda dan selanjutnya dilakukan penentuan konsentrasi ambang bawah dan ambang atas yang mematikan terhadap larva udang windu. Hasil penelitian menunjukkan bahwa dari 88 sampel herbal mangrove yang dikumpulkan 58 (65,91%) sampel positif mengandung antibakteri V. harveyi, yang terdiri atas: 11 (18,96%) dari Maros, 16 (27,59%) dari Pangkep, 11 (18,96%) dari Luwu Timur, 4 (6,90%) dari Takalar, dan 16 (27,59%) dari Bone. Minimum Inhibition Concentration(MIC) terbaik ditunjukkan oleh lima jenis tanaman mangrove yaitu; Sonneratia lanceolata dengan nilai MIC 0,1 mg/L dan Sonneratia alba, Sonneratia caseolaris, Bruguiera gymnorrhiza, serta Rhizophora mucronata dengan nilai MIC masing-masing 1 mg/L. Hasil uji tantang secara in vitro dengan V. harveyi menunjukkan bahwa S. alba dan S. caseolaris terbaik menghambat pertumbuhan V. harveyi. Konsentrasi 10.000 mg/L dari ekstrak metanol S. lanceolata, S. alba, S. caseolaris, serta B. gymnorrhiza sudah toksik bagi benur udang windu, dengan mortalitas mencapai 100% setelah 96 jam.
PERBAIKAN KUALITAS PAKAN DAN KINERJA PERTUMBUHAN IKAN NILA DENGAN PENAMBAHAN ENZIM PROTEASE BAKTERI PADA PAKAN FORMULASI
Authors: Kurniasih Titin , Utomo Nur Bambang Priyo , Azwar Zafril Imran , Mulyasari Mulyasari , Melati Irma 
Published: November 2016

Penelitian ini bertujuan menguji pengaruh pemberian enzim protease bakteri pada pakan formulasi terhadap kecernaan nutrien, efisiensi pakan, dan pertumbuhan ikan nila. Penelitian menggunakan rancangan acak lengkap (RAL) dengan lima perlakuan dan tiga ulangan, yaitu pakan formulasi kontrol tanpa penambahan enzim (FK 28), pakan formulasi yang ditambah enzim protease yang diproduksi oleh bakteri Bacillus cereus (FBc), pakan formulasi yang diberi enzim protease yang diproduksi oleh bakteri Staphylococcus epidermidis (FSe), pakan komersial berkadar protein 28% (KK 28), dan pakan komersial berkadar protein 31% (KK 31). Penelitian menggunakan ikan nila berukuran awal 4,07±0,25 g, dilakukan pada 15 buah akuarium berukuran 60 cm x 50 cm x 50 cm yang dilengkapi sistem resirkulasi selama enam puluh hari pengamatan. Hasil penelitian menunjukkan bahwa pemberian enzim protease bakteri Bacillus cereus secara signifikan mampu meningkatkan efisiensi pakan dan pertumbuhan ikan nila dibandingkan dengan pakan kontrol. Kecernaan protein dan total pakan meningkat secara signifikan dengan adanya penambahan enzim protease bakteri Staphylococcus epidermidis dan Bacillus cereus. Penambahan enzim bakteri Staphylococcus epidermidis dan Bacillus cereus juga secara nyata meningkatkan retensi protein dan palatabilitas pakan formulasi. Sintasan tidak berbeda nyata di antara kelima perlakuan. Diperoleh kesimpulan bahwa enzim protease kedua bakteri tersebut efektif untuk meningkatkan kualitas pakan dan kinerja pertumbuhan ikan nila.
ESTIMASI HERITABILITAS DAN RESPONS SELEKSI IKAN NILA MERAH (Oreochromis spp.) PADA TAMBAK BERSALINITAS
Authors: Robisalmi Adam , Dewi Raden Roro Sri Pudji Sinarni 
Published: November 2016

Salah satu jenis ikan nila yang memiliki potensi nilai ekonomis yang tinggi dan dapat dibudidayakan di air tawar maupun di air payau adalah ikan nila merah. Dalam rangka pengembangannya diperlukan upaya untuk meningkatkan kualitas genetik di antaranya dengan cara seleksi. Kegiatan ini bertujuan untuk mengetahui estimasi nilai heritabilitas dan respons seleksi populasi jantan dan betina F-0 ikan nila merah hasil seleksi. Pemijahan dilakukan secara full-sib dengan perbandingan jantan dan betina 1:1 dan menghasilkan 10 famili dari 50 famili yang dibentuk. Pembesaran benih dilakukan di tambak bersalinitas 30 ppt menggunakan waring berukuran 3 m x 5 m x 1,5 m dengan padat tebar 10 ekor/m2. Seleksi calon induk pada populasi jantan dan betina ikan nila merah dilakukan setelah mencapai bobot 200-300 g. Cut off seleksi ditentukan pada bobot berkisar 225-354 g (jantan) dan 201-258 g (betina). Parameter yang diamati meliputi koefisien keragaman panjang dan bobot, diferensial seleksi, estimasi nilai heritabilitas, dan respons seleksi. Hasil penelitian menunjukkan koefisien keragaman karakter panjang pada populasi jantan berkisar dari 7,89%-11,18% dan bobot 21,22%-34,12% dengan diferensial seleksi 45,87-115,18 g; sedangkan populasi betina sebesar 6,08%-13,22% dan 16,39%-31,55%; serta 46,12-71,67 g. Hasil analisis estimasi nilai heritabilitas dalam arti luas) pada karakter bobot ikan nila merah jantan 0,47±0,19 dan betina 0,19±0,11. Adapun prediksi respons seleksi yang akan diperoleh adalah 33,06 g (jantan) dan 11,65 g (betina).
LAJU PENGOSONGAN ISI PERUT PADA IKAN KERAPU CANSIR (Epinephelus fuscoguttatus x Epinephelus corallicola) SEBAGAI INFORMASI AWAL DALAM PENENTUAN MANAJEMEN PEMBERIAN PAKAN
Authors: Kusumawati Daniar , Ismi Suko 
Published: November 2016

Informasi mengenai laju pengosongan isi perut suatu jenis ikan sangat diperlukan untuk meningkatkan keefektifan dan keefisienan pemanfaatan pakan. Dalam penelitian ini dilakukan uji untuk mengetahui lama pengosongan isi perut benih kerapu cansir yaitu hibrida dari kerapu macan (Epinephelus fuscoguttatus) x kerapu pasir (Epinephelus corallicola) terhadap jenis pakan pelet. Benih kerapu cansir sejumlah 50 ekor dengan kisaran panjang 8,00 ± 0,76 cm terlebih dahulu dipuasakan selama 48 jam dan kemudian ikan diberi makan secara adlibitum. Ikan selanjutnya dibedah sejumlah lima ekor pada jam ke-0, 6, 12, 15, 18, 21, 24, 30, 35, dan 42. Berdasarkan hasil pengamatan diketahui bahwa lama pengosongan isi perut berdasarkan persentase derajat kepenuhan isi perut per satuan waktu (ISC) pada ikan kerapu cansir ukuran 8,00 ± 0,76 cm terhadap jenis pakan pelet mencapai 28 jam dengan total laju kecepatan pengosongan lambung rata-rata terhadap penurunan persentase pakan sebesar 2,9%/jam. Berdasarkan lama pengosongan isi perutnya, ikan kerapu cansir cukup diberikan pakan pelet dengan frekuensi satu kali per hari.
La formación en ciudadanía en escenarios de educación inicial: una experiencia con madres comunitarias
Authors: Rodríguez Huesa Arly Adriana , Flórez Romero Rita , Gómez Muñoz Diana Paola 
Published: November 2016

El presente artículo analiza la formación ciudadana que brindan las Madres Comunitarias de la ciudad de Bogotá a niños y niñas de la Primera Infancia. Para ello se organizaron grupos focales con 27 Madres Comunitarias que hacen parte del programa Técnico en Atención Integral a la Primera Infancia (A.I.P.I) del Servicio Nacional del SENA. Se establecieron tres categorías para el análisis: Participación, Autonomía y Pensamiento Cuidante. Se realizó la visita al Hogar Comunitario Agrupado Domingo Savio de la localidad Santafé, y en este ejercicio emergieron tres nuevas categorías: Ciudadanía en las Madres Comunitarias, Juicio Moral y Resolución de conflictos, lo cual permitió ampliar el análisis. El estudio arroja entre sus resultados la importancia de concebir a los niños y niñas de la Primera Infancia como interlocutores válidos y comprenderlos como sujetos políticos. Además, se observó que las educadoras, desde su condición de género, aportan elementos para comprender la ciudadanía de los más pequeños, y que la formación que brinda el SENA ha tenido un impacto positivo en la resignificación de su ciudadanía, lo cual ha tenido una afectación en la orientación ciudadana que promueven.
Factores clínicos asociados a la hipertensión arterial severa posparto: un estudio de casos y controles en la Clínica San Luis, Bucaramanga, Colombia
Authors: Ospina G. Sandra Cecilia , Núñez M. Andrés Felipe 
Published: November 2016

<p>Este estudio observacional analítico de casos y controles de base hospitalaria, con información obtenida de historias clínicas, busca determinar los factores clínicos asociados a la hipertensión arterial severa posparto y la magnitud de dicha asociación en la población obstétrica que ingresó entre 2010 y 2012 a la Clínica Materno Infantil San Luis, Bucaramanga, Colombia. Los casos fueron mujeres con parto atendido en dicha institución en ese periodo y diagnosticadas con hipertensión arterial severa puerperal,incluidas quienes se diagnosticaron en el posparto antes de su egreso hospitalario o en un reingreso.</p><p>Los controles se seleccionaron aleatoriamente y corresponden a mujeres con parto atendido en la Clínica durante el mismo periodo y que no presentaron hipertensión arterial severa puerperal. Se excluyeron historias clínicas incompletas, mujeres con lupus eritematoso sistémico o que recibieron bromocriptina o derivados del ergot durante el parto o puerperio. Se analizaron variables demográficas y clínicas. Se calculó una muestra de 327 gestantes (163 por grupo), para una prevalencia de hiperuricemia anteparto del 2% como principal variable de exposición a evaluar; un nivel de significancia del 5%, un poder del 80%, una precisión de 1,5% y un efecto de diseño de 1,0. Se incluyeron 446 maternas, 222 casos y 224 controles. La hipertensión gestacional RM 3,19 (IC 95% 1,88-5,41) y la hiperuricemia anteparto RM 2,68 (IC 95% 1,29-5,55) fueron variables de riesgo para el desenlace. Se concluye que la hipertensión gestacional y la hiperuricemia anteparto son las principales variables de riesgo para hipertensión arterial severa puerperal.</p>