bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Genome Sequence of the High-Natamycin-Producing Strain
Streptomyces gilvosporeus
F607
Authors: Zong Gongli , Zhong Chuanqing , Fu Jiafang , Zhao Zhilong , Cao Guangxiang 
Published: January 2018

ABSTRACT

Streptomyces gilvosporeus
strain F607 is a producer of high levels of natamycin used in the fermentation industry. In this study, the complete genome sequence of strain F607 was determined. This genome sequence provides a basis for understanding natamycin biosynthesis and regulation in a high-natamycin-producing strain and will aid in the development of useful strategies for improving industrial strains.
Complete Genome Sequences of 14
Salmonella enterica
Serovar Enteritidis Strains Recovered from Human Clinical Cases between 1949 and 1995 in the United States
Authors: Tadesse Daniel A. , Hoffmann Maria , Sarria Saul , Lam Claudia , Brown Eric , Allard Marc , McDermott Patrick F. 
Published: January 2018

ABSTRACT

Salmonella enterica
serovar Enteritidis is one of the most commonly isolated foodborne pathogens and is transmitted primarily to humans through consumption of contaminated poultry and poultry products. We are reporting completely closed genome and plasmid sequences of historical
S
. Enteritidis isolates recovered from humans between 1949 and 1995 in the United States.
Using a composite morbidity score and cultural survey to explore characteristics of high proficiency neonatal intensive care units
Authors: Kaempf Joseph W , Wang Lian , Dunn Michael 
Published: January 2018

BackgroundContinuous quality improvement (CQI) collaboration has not eliminated the morbidity variability seen among neonatal intensive care units (NICUs). Factors other than inconstant application of potentially better practices (PBPs) might explain divergent proficiency.ObjectiveMeasure a composite morbidity score and determine whether cultural, environmental and cognitive factors distinguish high proficiency from lower proficiency NICUs.Design/methodsRetrospective analysis using a risk-adjusted composite morbidity score (Benefit Metric) and cultural survey focusing on very low birth weight (VLBW) infants from 39 NICUs, years 2000–2014. The Benefit Metric and yearly variance from the group mean was rank-ordered by NICU. A comprehensive survey was completed by each NICU exploring whether morbidity variance correlated with CQI methodology, cultural, environmental and/or cognitive characteristics.Results58 272 VLBW infants were included, mean (SD) age 28.2 (3.0) weeks, birth weight 1031 (301) g. The 39 NICU groups’ Benefit Metric improved 40%, from 80 in 2000 to 112 in 2014 (P<0.001). 14 NICUs had composite morbidity scores significantly better than the group, 16 did not differ and 9 scored below the group mean. The 14 highest performing NICUs were characterised by more effective team work, superior morale, greater problem-solving expectations of providers, enhanced learning opportunities, knowledge of CQI fundamentals and more generous staffing.ConclusionCultural, environmental and cognitive characteristics vary among NICUs perhaps more than traditional CQI methodology and PBPs, possibly explaining the inconstancy of VLBW infant morbidity reduction efforts. High proficiency NICUs foster spirited team work and camaraderie, sustained learning opportunities and support of favourable staffing that allows problem solving and widespread involvement in CQI activities.
Coastal wetland loss, consequences, and challenges for restoration
Authors: Li Xiuzhen , Bellerby Richard , Craft Christopher , Widney Sarah E. 
Published: January 2018

Abstract
Coastal wetlands mainly include ecosystems of mangroves, coral reefs, salt marsh, and sea grass beds. As the buffer zone between land and sea, they are frequently threatened from both sides. The world coastal wetland lost more than 50% of its area in the 20th century, largely before their great value, such as wave attenuation, erosion control, biodiversity support, and carbon sequestration, was fully recognized. World wetland loss and degradation was accelerated in the last three decades, caused by both anthropogenic and natural factors, such as land reclamation, aquaculture, urbanization, harbor and navigation channel construction, decreased sediment input from the catchments, sea level rise, and erosion. Aquaculture is one of the key destinations of coastal wetland transformation. Profound consequences have been caused by coastal wetland loss, such as habitat loss for wild species, CO2 and N2O emission from land reclamation and aquaculture, and flooding. Great efforts have been made to restore coastal wetlands, but challenges remain due to lack of knowledge about interactions between vegetation and morphological dynamics. Compromise among the different functionalities remains a challenge during restoration of coastal wetlands, especially when faced with highly profitable coastal land use. To solve the problem, multi-disciplinary efforts are needed from physio-chemical–biological monitoring to modelling, designing, and restoring practices with site-specific knowledge.
Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors
Authors: Strauss Julius , Heery Christopher R. , Schlom Jeffrey , Madan Ravi A. , Cao Liang , Kang Zhigang , Lamping Elizabeth , Marté Jennifer L. , Donahue Renee N. , Grenga Italia , Cordes Lisa , Christensen Olaf , Mahnke Lisa , Helwig Christoph , Gulley James L. 
Published: January 2018

Abstract
Purpose: M7824 (MSB0011359C) is an innovative first-in-class bifunctional fusion protein composed of a mAb against programmed death ligand 1 (PD-L1) fused to a TGFβ “trap.”
Experimental Design: In the 3+3 dose-escalation component of this phase I study (NCT02517398), eligible patients with advanced solid tumors received M7824 at 1, 3, 10, or 20 mg/kg once every 2 weeks until confirmed progression, unacceptable toxicity, or trial withdrawal; in addition, a cohort received an initial 0.3 mg/kg dose to evaluate pharmacokinetics/pharmacodynamics, followed by 10 mg/kg dosing. The primary objective is to determine the safety and maximum tolerated dose (MTD); secondary objectives include pharmacokinetics, immunogenicity, and best overall response.
Results: Nineteen heavily pretreated patients with ECOG 0–1 have received M7824. Grade ≥3 treatment-related adverse events occurred in four patients (skin infection secondary to localized bullous pemphigoid, asymptomatic lipase increase, colitis with associated anemia, and gastroparesis with hypokalemia). The MTD was not reached. M7824 saturated peripheral PD-L1 and sequestered any released plasma TGFβ1, -β2, and -β3 throughout the dosing period at &gt;1 mg/kg. There were signs of efficacy across all dose levels, including one ongoing confirmed complete response (cervical cancer), two durable confirmed partial responses (PR; pancreatic cancer; anal cancer), one near-PR (cervical cancer), and two cases of prolonged stable disease in patients with growing disease at study entry (pancreatic cancer; carcinoid).
Conclusions: M7824 has a manageable safety profile in patients with heavily pretreated advanced solid tumors. Early signs of efficacy are encouraging, and multiple expansion cohorts are ongoing in a range of tumors. Clin Cancer Res; 24(6); 1287–95. ©2018 AACR.
When Church and Cinema Combine: Blurring Boundaries through Media-savvy Evangelicalism
Authors: Justice Deborah 
Published: January 2018

The use of social media presents new religious groups with opportunities to assert themselves in contrast to established religious institutions. Intersections of church and cinema form a central part of this phenomenon. On one hand, many churches embrace digital media, from Hollywood clips in sermons to sermons delivered entirely via video feed. Similarly and overlapping with this use of media, churches in cinemas have emerged around the world as a new form of Sunday morning worship.
This paper investigates intersections of church and cinema through case studies of two representative congregations. CityChurch, in Würzburg, Germany, is a free evangelical faith community that meets in a downtown Cineplex for Sunday worship. LCBC (Lives Changed by Christ) is one of the largest multi-sited megachurches on the American East Coast. While LCBC’s main campus offers live preaching, sermons are digitally streamed to the rest. Both CityChurch and LCBC exemplify growing numbers of faith communities that rely on popular musical and social media to 1) redefine local and global religious relationships and 2) claim identity as both culturally alternative and spiritually authentic.
By engaging with international flows of worship music, films, and viral internet sensations, new media-centered faith communities like CityChurch and LCBC reconfigure established sacred soundscapes. CityChurch’s use of music and media strategically differentiates the congregation from neighboring traditional forms of German Christianity while strengthening connections to the imagined global evangelical community. LCBC creates what cultural geographer Justin Wilford dubs a “postsuburban sacrality” that carves out meaning from the banality of strip-mall-studded suburban existence. Analyzing the dynamics of music and media in these new worship spaces assumes growing importance as transnational music and media choices play an increasingly a central role in locally differentiating emergent worship communities from historically hegemonic religious neighbors.
Ezetimibe
Authors: Cada Dennis J. , Levien Terri , Baker Danial E. 
Published: January 2018

Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late Phase III trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. The monographs are published in printed form and on diskettes that allow customization. Subscribers to the The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. If you would like information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800–322–4349. The March 2003 monograph topics are adalimumab, eletriptan, cyclosporine ophthalmic emulsion, montelukast for allergic rhinitis, and icodextrin peritoneal dialysis solution. The DUE is on adalimumab.
Aprepitant
Authors: Cada Dennis J. , Levien Terri , Baker Danial E. 
Published: January 2018

Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late Phase III trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. The monographs are published in printed form and on diskettes that allow customization. Subscribers to the The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. If you would like information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800–322–4349. The June 2003 monograph topics are aprepitant, gemifloxacin, desirudin for injection, gatifloxacin ophthalmic solution, and pegvisomant. The DUE is on aprepitant.
FDA Requirements for Manufacturer Labeling of Oral Iron Products Need Upgrading Intrathecal Injection of Ionic Contrast Media may be Fatal
Authors: Cohen Michael R. 
Published: January 2018

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them in your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the USP Medication Errors Reporting Program, which is presented in cooperation with the Institute for Safe Medication Practices. If you have encountered medication errors and would like to report them, you may call USP toll-free, 24 hours a day, at 800-233-7767 (800-23-ERROR). Any reports published by ISMP will be anonymous. Comments are also invited; the writers’ names will be published if desired. ISMP may be contacted at the address shown below.
Montelukast-Induced Urticaria; Acute Ischemic Colitis Caused by Anaphylactic Reaction; Pulmonary Edema Associated with a COX-2 Inhibitor; Hepatotoxicity with Citalopram; CNS Disturbances with Alendronate; Long QT Syndrome and QT Prolongation with Famotidine; Two Recommended Reviews
Authors: Shuster Joel 
Published: January 2018

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), to discuss methods of prevention, and to promote reporting of ADRs to the FDA's MEDWATCH program (800-FDA-1088). If you have reported an interesting preventable ADR to MEDWATCH, please consider sharing the account with our readers. In 2004, ISMP is celebrating the 10th anniversary of its incorporation as a nonprofit organization. The Institute represents more than 20 years of experience in helping health care practitioners keep patients safe, and continues to lead efforts to improve the medication use process.
Zonisamide: Binge Eating Disorder
Authors: Generali Joyce , Cada Dennis J. 
Published: January 2018

Off-Label Drug Uses This Hospital Pharmacy feature is extracted from Off-Label DrugFacts, a quarterly publication available from Facts and Comparisons. Off-Label DrugFacts is a practitioner-oriented resource for information about specific FDA-unapproved drug uses. This new guide to the literature will enable the health care professional/clinician to quickly identify published studies on off-label uses and to determine if a specific use is rational in a patient care scenario. The most relevant data are provided in tabular form so that the reader can easily identify the scope of information available. A summary of the data—including background, study design, patient population, dosage information, therapy duration, results, safety, and therapeutic considerations—precedes each table of published studies. References direct the reader to the full literature for more comprehensive information prior to patient care decisions. Direct questions or comments on “Off-Label Drug Uses” to hospitalpharmacy@drugfacts.com .
A conflicted drug policy – the normalisation of the drug problem in Finland
Authors: Hakkarainen Pekka , Tigerstedt Christoffer 
Published: January 2018

Drug use and its attendant problems in Finland are still far removed from the top levels in Europe. Nonetheless, a considerably more conflicted drug political situation than the earlier prevailing consensus around a restrictive policy has quickly emerged. In less than a decade, drugs have become a recognised social fact and problem that must be addressed, though probably never entirely eradicated. The article tests the thesis of the normalisation of drug use that is often brought up in the international debate. The British debate can be summarized in two main points: the significant increase of supply and demand (‘normal’ as “widespread”) as well as the increased social and cultural acceptance of drug use (‘normal’ as “accepted”). The article shows that there can be no talk of normalisation in Finland in terms of these two issues. However, in many ways drug problems have become a commonplace in the country and have thus forced the authorities, political decision-makers and other actors to re-evaluate thoroughly the drug issue. In this sense there are grounds for the normalisation of drugs (‘normal’ as “a social fact”). The article reviews the reports, official documents and new statutes drawn up on drugs during the past decade. In addition, drug political reforms that have caused controversy are also covered. It is thus concluded that drug policy has retreated from a unified policy based on a penal conception towards a more varied and conflicted policy model.
Oncology Pharmacist Opportunities: Closing the Gap in Quality Care
Authors: Vulaj Vera , Hough Shannon , Bedard Louise , Farris Karen , Mackler Emily 
Published: January 2018

Purpose: ASCO has worked to facilitate the improvement in quality oncology care via the development of the Quality Oncology Practice Initiative (QOPI). The extent to which the ASCO QOPI identifies areas in which pharmacists may enhance care is not known. These findings are important, as pharmacists are an integral part of the care team, providing direct clinical care in addition to medication use guidelines and practice-based policies. In addition, high-performing practices may receive reimbursement from the Centers for Medicare and Medicaid Services. Methods: Three pharmacists reviewed 200 QOPI measures for potential pharmacist involvement. We used the Hematology/Oncology Pharmacy Association Scope of Practice document and a validated summary of services provided by board-certified oncology pharmacists to identify which practice domains and pharmacy services would best fit the care provided by the selected QOPI measures. Results: A total of 177 QOPI measures were analyzed. Potential areas of pharmacist impact were identified in 67 (38%) of the included metrics. Measures largely related to optimizing drug therapy through the development and implementation of pharmacy guidelines. Patient counseling and symptom management are services that best described the majority of QOPI measures deemed actionable by a pharmacist. We also found that several QOPI measures pharmacists can intervene upon overlap with metrics currently assessed for reimbursement via the Centers for Medicare and Medicaid Services Merit-Based Incentive Payment System. Conclusion: Oncology pharmacists are uniquely positioned to improve the quality of care provided to patients with cancer within the team-based setting.
LIE ALGEBRA REPRESENTATIONS AND RIGGED HILBERT SPACES: THE SO(2) CASE
Authors: Celeghini Enrico , Gadella Manuel , Del Olmo Mariano A 
Published: January 2018

It is well known that related with the irreducible representations of the Lie group <em>SO</em>(2) we find a discrete basis as well a continuous one. In this paper we revisited this situation under the light of Rigged Hilbert spaces, which are the suitable framework to deal with both discrete and bases in the same context and in relation with physical applications.
ON THE SPECTRUM OF THE ONE-DIMENSIONAL SCHRÖDINGER HAMILTONIAN PERTURBED BY AN ATTRACTIVE GAUSSIAN POTENTIAL
Authors: Fassari Silvestro , Gadella Manuel , Nieto Luis Miguel , Rinaldi Fabio 
Published: January 2018

<p>We propose a new approach to the problem of finding the eigenvalues (energy levels) in the discrete spectrum of the one-dimensional Hamiltonian with an attractive Gaussian potential by using the well-known Birman-Schwinger technique. However, in place of the Birman-Schwinger integral operator we consider an isospectral operator in momentum space, taking advantage of the unique feature of this potential, that is to say its invariance under Fourier transform. <br />Given that such integral operators are trace class, it is possible to determine the energy levels in the discrete spectrum of the Hamiltonian as functions of <span>the coupling constant with great accuracy by solving a finite number of transcendental equations. We also address the important issue of the coupling constant thresholds of the Hamiltonian, that is to say the critical values of λ for which we have the emergence of an additional bound state out of the absolutely continuous spectrum. </span></p>
MASA PEMBAYARAN BEBAN NAFKAH IDDAH DAN MUT’AH DALAM PERKARA CERAI TALAK (Sebuah Implementasi Hukum Acara di Pengadilan Agama)
Authors: Annas Syaiful 
Published: January 2018

This paper will discuss the implementation of payment of iddah and mut'ah in the divorce (raj’i). Judges often faced a problem between text and context. Their decision imposes on men pays iddah and mut'ah life as a right for his ex-wife, but it was not implemented as the judge's decision, so that women tend to be disadvantaged ones, although the formal law can be prosecuted fiat execution, but it is not easy for a woman, sometimes the cost of iddah and mut'ah charge is not comparable with the cost of carrying out the execution, not to mention ex-husband who went (fuzzy) away unnoticed after divorce statement. Therefore the necessary of a legal breakthrough to provide legal certainty for the rights of womens through the judge's decision, with consideration argumentative primarily to determine a living payout time of iddah And mut'ah. In this paper will be described legal reasons in court as legal considerations which contains elements of juridical, sociological, philosophical in decision [Tulisan ini hendak mendiskusikan bagaimana pelaksanaan pembebanan pembayaran nafkah iddah dan mut’ah dalam perkara talak (raj'i). Seringkali hakim dihadapkan pada problematika antara teks dan konteks. Adanya putusan yang membebankan terhadap laki-laki membayar sejumlah nafkah iddah dan mut’ah sebagai hak bagi mantan istri, akan tetapi tidak dilaksanakan sebagaimana putusan hakim, sehingga perempuan cenderung dirugikan, meskipun secara yuridis-formil dapat dituntut fiat eksekusi, tetapi tidak mudah bagi pihak perempuan, karena kadang biaya pembebanan nafkah iddah dan mut’ah tidak sebanding dengan biaya melaksanakan eksekusi, belum lagi problem mantan suami yang pergi tanpa diketahui lagi keberadaannya setelah pengucapan ikrar talaknya. Oleh karena itu perlu terobosan hukum guna menjamin hak perempuan tersebut melalui putusan hakim dengan pertimbangan yang argumentatif terutama untuk menentukan masa pembayaran nafkah iddah dan mut’ah tersebut. Dalam tulisan ini akan diurai alasan hukum dalam putusan pengadilan sebagai bahan pertimbangan hukum yang memuat unsur yuridis, sosiologis, filosofis dalam putusan tersebut.]