bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alluvial and fluvial fans on Saturn's moon Titan reveal processes, materials and regional geology
Authors: Radebaugh Jani , Ventra Dario , Lorenz Ralph D. , Farr Tom , Kirk Randy , Hayes Alex , Malaska Michael J. , Birch Sam , Liu Zac Yung-Chun , Lunine Jonathan , Barnes Jason , Le Gall Alice , Lopes Rosaly , Stofan Ellen , Wall Steve , Paillou Philippe 
Published: February 2016

Abstract

Fans, landforms that record the storage and transport of sediment from uplands to depositional basins, are found on Saturn's moon Titan, a body of significantly different process rates and material compositions from Earth. Images obtained by the Cassini spacecraft's synthetic aperture radar reveal morphologies, roughness, textural patterns and other properties consistent with fan analogues on Earth also viewed by synthetic aperture radar. The observed fan characteristics on Titan reveal some regions of high relative relief and others with gentle slopes over hundreds of kilometres, exposing topographic variations and influences on fan formation. There is evidence for a range of particle sizes across proximal to distal fan regions, from
c.
2 cm or more to fine-grained, which can provide details on sedimentary processes. Some features are best described as alluvial fans, which implies their proximity to high-relief source areas, while others are more likely to be fluvial fans, drawing from larger catchment areas and frequently characterized by more prolonged runoff events. The presence of fans corroborates the vast liquid storage capacity of the atmosphere and the resultant episodic behaviour. Fans join the growing list of landforms on Titan derived from atmospheric and fluvial processes similar to those on Earth, strengthening comparisons between these two planetary bodies.
A Phase I Clinical, Pharmacokinetic, and Pharmacodynamic Study of Weekly or Every Three Week Ixabepilone and Daily Sunitinib in Patients with Advanced Solid Tumors
Authors: Montero Alberto J. , Kwon Deukwoo , Flores Aurea , Kovacs Krisztina , Trent Jonathan C. , Benedetto Pasquale , Rocha-Lima Caio , Merchan Jaime R. 
Published: February 2016

Abstract
Purpose: To evaluate the safety, MTD, pharmacokinetics/pharmacodynamics, and early clinical activity of ixabepilone given either weekly or every 3 weeks in combination with daily sunitinib in patients with advanced solid tumors.
Experimental Design: Eligible patients received either weekly (schedule A) or every 3 weeks (schedule B) ixabepilone at escalating doses (schedule A: 7.5, 15, or 20 mg/m2; schedule B: 20, 30, or 40 mg/m2), and oral sunitinib (37.5 mg daily), starting on day 8 of cycle 1. Dose-limiting toxicities (DLT) were assessed during cycle 1.
Results: The ixabepilone and sunitinib combination was fairly well tolerated. DLTs were observed in 3 subjects (1 in schedule 3A and 2 in schedule 3B). The most common grade 3–4 hematologic and nonhematologic adverse events were leukopenia and fatigue, respectively. Four patients (3 in schedule A) achieved a partial response, while 13 patients had stable disease. Nine of 17 heavily pretreated colorectal cancer patients had clinical benefit. Coadministration of sunitinib with ixabepilone on a weekly (but not every 3 week) schedule was associated with a significant increase in the half-life and a significant decrease in the clearance of ixabepilone. Correlative studies demonstrated a significant association between higher baseline plasma angiogenic activity (PAA) and clinical benefit in schedule A patients. Weekly, but not every 3 weeks, ixabepilone led to a significant decrease in PAA postbaseline.
Conclusions: Coadministration of ixabepilone with sunitinib has acceptable toxicity and encouraging clinical activity in heavily pretreated patients, particularly in patients with metastatic colorectal cancer. Clin Cancer Res; 22(13); 3209–17. ©2016 AACR.
miRNA Deregulation in Cancer Cells and the Tumor Microenvironment
Authors: Rupaimoole Rajesha , Calin George A. , Lopez-Berestein Gabriel , Sood Anil K. 
Published: February 2016

Abstract
miRNAs are a key component of the noncoding RNA family. The underlying mechanisms involved in the interplay between the tumor microenvironment and cancer cells involve highly dynamic factors such as hypoxia and cell types such as cancer-associated fibroblasts and macrophages. Although miRNA levels are known to be altered in cancer cells, recent evidence suggests a critical role for the tumor microenvironment in regulating miRNA biogenesis, methylation, and transcriptional changes. Here, we discuss the complex protumorigenic symbiotic role between tumor cells, the tumor microenvironment, and miRNA deregulation.
Significance: miRNAs play a central role in cell signaling and homeostasis. In this article, we provide insights into the regulatory mechanisms involved in the deregulation of miRNAs in cancer cells and the tumor microenvironment and discuss therapeutic intervention strategies to overcome this deregulation. Cancer Discov; 6(3); 235–46. ©2016 AACR.
NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines
Authors: Jaime-Ramirez Alena C. , McMichael Elizabeth L. , Kondadasula SriVidya , Skinner Cassandra C. , Mundy-Bosse Bethany L. , Luedke Eric , Jones Natalie B. , Mani Aruna , Roda Julie , Karpa Volodymyr , Li Hong , Li Jilong , Elavazhagan Saranya , La Perle Krista M. , Schmitt Alessandra C. , Lu Yanhui , Zhang Xiaoli , Pan Xueliang , Mao Hsaioyin , Davis Melanie , Jarjoura David , Butchar Jonathan P. , Poi Ming , Phelps Mitch , Tridandapani Susheela , Byrd John C. , Caligiuri Michael A. , Lee Robert J. , Carson William E. 
Published: February 2016

Abstract
Optimally effective antitumor therapies would not only activate immune effector cells but also engage them at the tumor. Folate conjugated to immunoglobulin (F-IgG) could direct innate immune cells with Fc receptors to folate receptor–expressing cancer cells. F-IgG bound to human KB and HeLa cells, as well as murine L1210JF, a folate receptor (FR)–overexpressing cancer cell line, as determined by flow cytometry. Recognition of F-IgG by natural killer (NK) cell Fc receptors led to phosphorylation of the ERK transcription factor and increased NK cell expression of CD69. Lysis of KB tumor cells by NK cells increased by about 5-fold after treatment with F-IgG, an effect synergistically enhanced by treatment with IL2, IL12, IL15, or IL21 (P &lt; 0.001). F-IgG also enhanced the lysis of chronic lymphocytic leukemia cells by autologous NK cells. NK cells significantly increased production of IFNγ, MIP-1α, and RANTES in response to F-IgG–coated KB target cells in the presence of the NK cell–activating cytokine IL12, and these coculture supernatants induced significant T-cell chemotaxis (P &lt; 0.001). F-IgG-coated targets also stimulated FcR-mediated monocyte effector functions. Studies in a murine leukemia model confirmed the intratumoral localization and antitumor activity of F-IgG, as well as enhancement of its effects by IL12 (P = 0.05). The antitumor effect of this combination was dependent on NK cells and led to decreased tumor cell proliferation in vivo. Thus, F-IgG can induce an immune response against FR-positive tumor cells that is mediated by NK cells and can be augmented by cytokine therapy. Cancer Immunol Res; 4(4); 323–36. ©2016 AACR.
Survival in primary antiphospholipid syndrome
Authors: Merashli Mira , Ster Irina , D’Andrea Giovanna , Iannaccone Luigi , Marottoli Vincenzo , Margaglione Maurizio , Brancaccio Vincenzo , Ames Paul 
Published: February 2016

SummaryThe vascular mortality of antiphospholipid syndrome (APS) ranges from 1.4 % to 5.5 %, but its predictors are poorly known. It was the study objective to evaluate the impact of baseline lupus anticoagulant assays, IgG anticardiolipin (aCL), plasma fibrinogen (FNG) and von Willebrand factor (VWF), platelets (PLT) and of genetic polymorphisms of methylenetetrahydrofolate reductase C677T, of prothrombin G20210A and of paraoxonase-1 Q192R on survival in primary APS (PAPS). Cohort study on 77 thrombotic PAPS and 33 asymptomatic carriers of aPL (PCaPL) seen from 1989 to 2015 and persistently positive for aPL as per annual review. At baseline all participants were tested twice for the ratios of kaolin clotting time (KCTr), activated partial thromboplastin time (aPTTr), dilute Russell viper venom time (DRVVTr), IgG aCL, FNG, VWF and once for PLT. All thrombotic PAPS were on warfarin with regular INR monitoring. During follow-up 11 PAPS deceased (D-PAPS) of recurrent thrombosis mostly arterial, despite adequate anticoagulation yielding an overall vascular mortality of 10 %. D-PAPS had the strongest baseline aPTTr and DRVVTr and the highest mean baseline IgG aCL, FNG, VWF and PLT. Cox proportional hazards model identified baseline DRVVTr and FNG as main predictors of mortality with adjusted hazard ratios of 5.75 (95 % confidence interval [CI]: 1.5, 22.4) and of 1.03 (95 %CI: 1.01, 1.04), respectively. In conclusion, plasma DRVVTr and FNG are strongly associated with the risk of vascular death in PAPS; while FNG lowering agents exist further research should be directed at therapeutic strategies able to dampen aPL production.
A new species of Cinnamomum (Lauraceae) from Nilgiris, southern Western Ghats, India
Authors: Geethakumary M P , Pandurangan Alagramam Govindasamy , Deepu S 
Published: February 2016

A new species of Cinnamomum (Lauraceae), C. nilagiricum is described and illustrated on the basis of distinct morphological characters known from Nilgiris, southern Western Ghats, India. It is allied to C. dubium but differs in the nature of trunk; shape, size and smell of leaves; 4-locellate anthers of whorl III stamens etc. A detailed description, distribution, phenology, illustration, colour plates and relevant notes are provided.
Climbing With a Head-Mounted Display
Authors: Woodham Alexander , Billinghurst Mark , Helton William S. 
Published: February 2016

Objective: We explored the dual-task costs of climbers performing a visual communication task using a head-mounted display (HMD) while simultaneously climbing along a vertical surface. Background: Climbing is affected by secondary auditory cognitive tasks, and climbing impairs later recall of secondary task information; the effects of visually presented tasks are less clear. Given that HMDs are projected to be adopted into emergency response work, questions are raised about the effects of HMD use during climbing or other physical tasks. Method: Climbers performed five conditions—a climbing-only condition, two dual-task climbing conditions (words presented on the HMD with and without auditory warnings while climbing), and two seated control conditions (words presented on the HMD with and without auditory warnings)—in a repeated-measures design. Motion data were also collected to examine participant motion around word presentation. Results: We found a decrease in both climbing performance and word recall under dual-task conditions, paralleling results found in previous research using auditory tasks. Participants slowed around word presentations on the HMD. Additional comparisons to previous research indicate that physical tasks may be more detrimental to word recall than are seated tasks and that visual stimuli might hinder climbing performance more than do audible stimuli. Conclusion: Complex physical activity, like climbing, is disruptive to memory rehearsal and later recall, and cognitive tasks disrupt physical performance. Application: Avoiding cognitive HMD tasks requiring later recall during complex physical activity is advisable. However, these systems may be developed to provide intelligent assistance, or memory augmentation, in these settings.
The Role of Policy Makers in the Formulation and Implementation of Public Policy for Brazilian Agriculture
Authors: Pereira Leite Sergio 
Published: February 2016

A processual approach to public policy analysis rather than the more common instrumental one can help us to understand the experience of policy makers involved in government programs related to rural Brazil and to evaluate the extent to which the implementation of rural policy is influenced by the networks and institutional environments in which administrators are engaged. A broader analytical framework for agrarian and agricultural policies, particularly those implemented during the two terms of the Lula administration (2003–2010), can be arrived at by examining the strategic political games in which public administrators were involved, the different forums in which these games were institutionalized (the spaces in which rural policies are created and implemented), and the institutional environments that structured and regulated the creation of these policies. Este trabalho aborda a experiência e a participação de gestores de políticas públicas envolvidos em programas governamentais relacionados ao meio rural brasileiro, visando compreender em que medida o ambiente institucional e as redes nas quais os mesmos estão inseridos condicionam o processo de implementação das ações observadas setorialmente, reforçando o emprego das análises de políticas públicas centradas na sua dimensão processual e não necessariamente instrumental, como é mais comum na literatura especializada. Focalizando os jogos políticos nos quais o corpo administrativo e técnico esteve envolvido (marcados por conflitos, barganhas e/ou negociações e envolvendo diversas administrações, grupos de interesses e outros stakeholders), os diferentes fóruns onde estes jogos foram institucionalizados (constituindo-se em loci privilegiados da produção e condução das políticas agrárias), e o ambiente institucional que estrutura e regula a produção destas políticas buscou-se desenhar um quadro mais amplo da análise de políticas agrárias e agrícolas, particularmente aquelas implementadas durante os dois mandatos do governo Lula (2003–2010).
Reversibility of Supraspinatus Muscle Atrophy in Tendon-Bone Healing After Arthroscopic Rotator Cuff Repair
Authors: Park Yong Bok , Ryu Ho Young , Hong Jin Ho , Ko Young Hoo , Yoo Jae Chul 
Published: February 2016

Background: To date, there are few reports of the definite reversibility of rotator cuff muscle atrophy after repair. Purpose: To evaluate the reversibility of rotator cuff muscle atrophy after successful arthroscopic repair. Study Design: Case series; Level of evidence, 4. Methods: Included in this study were 47 patients (mean age, 61.2 ± 7.3 years; range, 49-73 years) who underwent arthroscopic rotator cuff repair as well as magnetic resonance imaging (MRI) preoperatively and at 6-month and last follow-up. Patients who had confirmed rotator cuff healing (grades 1-3 according to the Sugaya classification) on both series of postoperative MRI were enrolled in the study. The mean time from the onset of symptoms to surgery was 24.7 ± 25.6 months (range, 3-120 months). The minimum follow-up was 2 years, and the mean follow-up duration was 41.8 ± 14.4 months. Serial changes in the supraspinatus muscle area on the most matching MRI scans (sagittal-oblique view) were evaluated. The area was measured by 2 independent observers. Results: Both independent observers reported no significant difference in the area of the supraspinatus muscle between the preoperative time point and 6-month follow-up (observer 1: P = .135; observer 2: P = .189). However, there was a significant difference between the 6-month and last follow-up (mean, 41.8 months; observers 1 and 2: P < .001). The serial changes in the area preoperatively and at 6-month and last follow-up were 419.41 ± 122.97 mm2, 431.76 ± 104.27 mm2, and 466.73 ± 121.42 mm2, respectively (observer 1), and 421.01 ± 116.61 mm2, 432.56 ± 100.78 mm2, and 469.84 ± 113.80 mm2, respectively (observer 2). The intraclass correlation coefficient between the 2 observers was 0.988. At final follow-up, the area increase on the medial and lateral aspects of the sagittal-oblique view compared with preoperatively was 13.9% ( P < .001) and 11.3% ( P < .001), respectively. Fatty infiltration did not change from preoperatively to 6-month follow-up ( P > .999) or from 6-month to final follow-up ( P = .077). Conclusion: After successful arthroscopic rotator cuff repair, there was a slight (11.3%-13.9%) increase in muscle volume from preoperatively to final follow-up, as seen on serial MRI. Fatty infiltration according to the Goutallier grade was not reversed ( P = .077). Some reversibility of supraspinatus muscle atrophy may exist in tendon-bone healing after arthroscopic rotator cuff repair; further follow-up is needed to better elucidate this result.
The Involvement of the Anterolateral Ligament in Rotational Control of the Knee
Authors: Sonnery-Cottet Bertrand , Lutz Christian , Daggett Matt , Dalmay François , Freychet Benjamin , Niglis Lucas , Imbert Pierre 
Published: February 2016

Background: Rotational control of the knee is crucial for knee stability. The anterolateral ligament (ALL) has been identified as a potentially important structure involved in rotational control of the knee. Purpose/Hypothesis: The purpose of this study was to determine, utilizing a navigation system, the involvement of the anterior cruciate ligament (ACL), the iliotibial band (ITB), and the ALL in tibial internal rotational control of the knee. The hypothesis was that the ALL would be involved in rotational control of the knee at varying degrees of knee flexion. Study Design: Controlled laboratory study. Methods: Twelve fresh-frozen cadaveric knees were tested in internal rotation at 20° and 90° of flexion and then subsequently tested using a simulated pivot-shift test consisting of coupled axial rotation at 30° of flexion. Serial sectioning of the ACL, ALL, and ITB was performed. On the contralateral knee, sectioning was performed in the reverse order. Measurements were collected using a surgical navigation system before and after each sectioning. Results: After ACL sectioning, an incision of the ALL induced a significant increase in internal rotation (+19.2% [ P = .0002] at 20°; +21.8% [ P = .0029] at 90°) and in coupled axial rotation (+43.0%; P = .0035) compared with the intact knee as well as a significant increase in internal rotation at 90° (+13.4%; P = .009) and in coupled axial rotation (+30.8%; P = .0124) compared with the ACL-deficient knee. After ITB sectioning, an additional ALL section caused a significant increase in internal rotation (+39.0% [ P = .002] at 20°; +63.0% [ P = .0147] at 90°) and in coupled axial rotation (+59.7%; P = .0003) compared with the intact knee as well as a significant increase in internal rotation at 90° (+14.8%; P = .0067) in comparison to the ITB-deficient knee. Conclusion: The ALL is involved in rotational control of the knee at varying degrees of knee flexion and during a simulated pivot shift. Concomitant to an ACL or ITB transection, sectioning the ALL further increased rotational laxity. Clinical Relevance: This laboratory study demonstrated that the ALL provides rotational control of the knee in combination with the ACL and/or ITB.
Research Gaps in the Use of Dairy Ingredients in Food Aid Products
Authors: DiRienzo Douglas 
Published: February 2016

Background: Nutritional interventions to help prevent stunting, particularly in the first 1000 days from conception to 2 years of a child’s life, are a major focus of numerous food aid organizations worldwide. Dairy ingredients can play an important role in enhancing the nutritional value and effectiveness of food products used in food aid. Objective: This article addresses gaps in research on malnutrition from both a broad perspective and specific to dairy ingredients. Methodology: Narrative review. Results and Conclusions: From a broad perspective, there is a need for gaining a consensus by the research community and funders of research on best practices for protocol development, outcomes measured, and reporting of study outcomes. Identification of biomarkers and rapid screening methods and consistent application of their use would expedite future research. A better understanding of nutritional requirements for malnourished populations, including the effects of energy deficits and disease on those requirements, is needed. More specific to dairy ingredients, a key research question is: Does dairy protein or the package of nutrients provided by dairy ingredients have a unique impact on growth, and if so, how? Also, data on the optimal levels of dairy ingredients based on the effective cost of treatment are needed, particularly in the treatment and prevention of moderate acute malnutrition and during pregnancy.
Healthcare resource use and costs associated with renal impairment in US patients with bone metastases from solid tumors
Authors: Qian Yi , Arellano Jorge , Bhowmik Debajyoti , Thomson Erin , Smith David M , Hechmati Guy , Song Xue 
Published: February 2016

Introduction During cancer progression, more than half of patients develop renal insufficiency, including chronic kidney disease. The primary and secondary objectives of this study were to estimate healthcare resource use and costs, respectively, associated with renal impairment in patients with bone metastases from solid tumors in the United States. Methods and materials This was a retrospective, observational cohort study conducted using administrative claims data for individuals with solid tumors and bone metastases. Control patients were matched to renal impairment patients using propensity scores (ratio up to 3:1) based on demographics, clinical characteristics, and baseline costs. Average per-patient per-year healthcare resource utilization and costs (total costs and cost components; 2013 dollars) were reported. Results In total, 2616 renal impairment patients were matched to 7211 control patients. Renal impairment patients had greater healthcare resource use compared with controls, including a greater mean number of hospital admissions (4.4 versus 2.1), longer average stay per hospital admission (7.4 versus 6.5 days), as well as greater mean number of physician office visits (22.9 versus 18.8), emergency department visits (3.1 versus 2.0), and hospital-based outpatient visits (18.8 versus 16.0) compared with control patients. Total costs were > $50,000 higher among renal impairment patients ($142,267 versus $88,839; P < 0.001), with hospital costs accounting for $72,557 for renal impairment patients, and $27,858 for control patients ( P < 0.001). Conclusion The healthcare resource use and costs associated with renal impairment in patients with bone metastases from solid tumors is high; efforts to reduce renal impairment in this population, including the potential avoidance of nephrotoxic agents, are warranted.