bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimates of genetic parameters for chemical traits of meat quality in Japanese black cattle
Authors: Sakuma Hironori , Saito Kaoru , Kohira Kimiko , Ohhashi Fumie , Shoji Noriaki , Uemoto Yoshinobu 
Published: May 2016

AbstractGenetic parameters for 54 carcass and chemical traits, such as general composition (moisture, crude fat and crude protein), fatty acid composition and water‐soluble compounds (free amino acids, peptides, nucleotides and sugars) of 587 commercial Japanese Black cattle were assessed. Heritability estimates for carcass traits and general composition ranged between 0.19–0.28, whereas those for fatty acid composition ranged between 0.11–0.85. Most heritability estimates for water‐soluble compounds were lower than 0.30; these traits were affected by aging period. Moderate heritability was observed for glutamine, alanine, taurine, anserine, inosine 5′‐monophosphate (IMP), inosine and myo‐inositol. In particular, heritability estimates were the highest (0.66) for taurine. Traits with moderate heritability were unaffected by aging period, with the exception of IMP, which was affected by aging period but exhibited moderate heritability (0.47). Although phenotypic correlations of water‐soluble compounds with carcass weight (CW), beef marbling standard (BMS) and monounsaturated fatty acid were generally low, genetic correlations between these traits were low to high. At the genetic level, most of the water‐soluble compounds were positively correlated with monounsaturated fatty acid but negatively correlated with CW and BMS. Thus, our results indicate that genetic variance and correlations could exist and be captured for some of the water‐soluble compounds.
Identification of an IGSF1‐specific deletion in a five‐generation pedigree with X‐linked Central Hypothyroidism without macroorchidism
Authors: Hughes James N. , Aubert Matthew , Heatlie Jessica , Gardner Alison , Gecz Jozef , Morgan Thomas , Belsky Joseph , Thomas Paul Q. 
Published: May 2016

SummaryObjectivesIGSF1 deficiency syndrome (IDS) is a recently described X‐linked congenital central hypothyroidism disorder characterized by loss‐of‐function mutations in the immunoglobulin superfamily member 1 (IGSF1) gene. The phenotypic spectrum and intrafamilial variability associated with IDS remain unclear due to a paucity of large, well‐characterized pedigrees. Here, we present phenotypic analysis and molecular characterization of a five‐generation pedigree with IGSF1 deficiency containing 10 affected males.Patients and methodsPituitary function was assessed in all available family members (n = 8 affected males and n = 5 carrier females). Molecular characterization of the family was performed by Sanger sequencing of PCR products amplified from the IGSF1 locus and by array comparative genomic hybridization.ResultsA 42‐kb IGSF1 deletion spanning the entire coding sequence was identified in all affected males. TSH deficiency, although subclinical in one case, was identified in all affected males (n = 8). PRL and GH deficiency were also present in 5 of 6 and 4 of 8 affected males, respectively. In contrast to previous reports, macroorchidism was not detected in any of the four affected males who were examined for this feature. Only 1 of 5 carrier females had pituitary dysfunction (TSH and GH deficiency).ConclusionIndividuals with identical IGSF1 deletions can exhibit variable pituitary hormone deficiencies, of which overt TSH deficiency is the most consistent feature. We also show that macroorchidism is not obligatory in males with IDS. Mutations of IGSF1 should therefore be considered in males with isolated hypopituitarism that includes TSH deficiency.
Presacral and intrathoracic extramedullary hematopoiesis in a patient with β thalassemia minor
Authors: Lalueza Antonio , Silva Carlos Patricio , Alcalá‐Galiano Andrea , Arrieta Estibaliz , Cánovas José Miguel , Calero Maria Rosa , Álvarez Carlos 
Published: May 2016

AbstractExtramedullary hematopoiesis (EMH) is a rare disease characterized by the presence of hematopoietic elements outside the bone marrow as a compensatory phenomenon in several hematological diseases, including thalassemia. We report a 64‐year‐old man with epigastric pain of 3‐months' duration radiated to the back. Imaging workup showed multiple paravertebral, retrosternal and presacral masses. Cytology findings obtained by CT‐guided FNAC were compatible with the diagnosis of EMH. Peripheral blood smear confirmed the presence of β‐thalassemia.
Nodular tracheobronchitis in a patient with lymphoma: an unusual presentation of viridans streptococcal respiratory tract infection
Authors: Lee Min A , Shin Kyung Min , Lim Jae‐Kwang , Cho Seung Hyun , Kim Hye Jung , Kim Gab Chul , Lee So Mi , Yoo Seung Soo 
Published: May 2016

AbstractBacterial tracheobronchitis without lung parenchymal involvement is extremely rare in adults, except in patients who are intubated or mechanically ventilated. We present a case of nodular tracheobronchitis caused by viridans streptococci in a non‐ventilated lymphoma patient. To our knowledge, this is the first report of viridans streptococcal infection that has caused nodular tracheobronchitis.
Risk factors for acute liver allograft rejection and their influences on treatment outcomes of rescue therapy in living donor liver transplantation
Authors: Shindoh Junichi , Akamatsu Nobuhisa , Tanaka Tomohiro , Kaneko Junichi , Tamura Sumihito , Sakamoto Yoshihiro , Hasegawa Kiyoshi , Sugawara Yasuhiko , Makuuchi Masatoshi , Kokudo Norihiro 
Published: May 2016

AbstractBackgroundSeveral clinical factors are reportedly correlated with acute cellular rejection (ACR) after liver transplantation. However, the factors that determine the response to rescue therapies remain unclear.MethodsA prospective database of 413 consecutive adult patients who underwent living donor liver transplantation (LDLT) was reviewed.ResultsNinety‐nine (24%) patients developed ACR after LDLT. A multivariate analysis revealed that a positive T‐lymphocytotoxic test (odds ratio [OR], 3.85; P=.017), HLA‐DR mismatch (OR, 2.99; P=.013), autoimmune disease (OR, 2.61; P=.001), and a younger recipient age (OR, 0.60 for +10 years; P<.001) were independent risk factors for ACR. Among these, autoimmune disease was significantly correlated with refractoriness to the standard rescue therapy (53% vs 30%, P=.02) and relapse of cellular rejection (34% vs 16%, P=.04). After rescue therapy, 98 of the 99 (99%) patients eventually recovered from ACR and graft loss was observed in only one patient. None of the risk factors for ACR impaired both graft survival and overall survival after LDLT.ConclusionsAutoimmune liver disease is associated with refractoriness to rescue therapy for ACR and the relapse of rejection. However, ACR does not affect the long‐term outcomes of LDLT if it is well controlled.
Co‐occurrence statistics as a language‐dependent cue for speech segmentation
Authors: Saksida Amanda , Langus Alan , Nespor Marina 
Published: May 2016

AbstractTo what extent can language acquisition be explained in terms of different associative learning mechanisms? It has been hypothesized that distributional regularities in spoken languages are strong enough to elicit statistical learning about dependencies among speech units. Distributional regularities could be a useful cue for word learning even without rich language‐specific knowledge. However, it is not clear how strong and reliable the distributional cues are that humans might use to segment speech. We investigate cross‐linguistic viability of different statistical learning strategies by analyzing child‐directed speech corpora from nine languages and by modeling possible statistics‐based speech segmentations. We show that languages vary as to which statistical segmentation strategies are most successful. The variability of the results can be partially explained by systematic differences between languages, such as rhythmical differences. The results confirm previous findings that different statistical learning strategies are successful in different languages and suggest that infants may have to primarily rely on non‐statistical cues when they begin their process of speech segmentation.
The organization of exploratory behaviors in infant locomotor planning
Authors: Kretch Kari S. , Adolph Karen E. 
Published: May 2016

AbstractHow do infants plan and guide locomotion under challenging conditions? This experiment investigated the real‐time process of visual and haptic exploration in 14‐month‐old infants as they decided whether and how to walk over challenging terrain – a series of bridges varying in width. Infants’ direction of gaze was recorded with a head‐mounted eye tracker and their haptic exploration and locomotor actions were captured on video. Infants’ exploration was an organized, efficient sequence of visual, haptic, and locomotor behaviors. They used visual exploration from a distance as an initial assessment on nearly every bridge. Visual information subsequently prompted gait modifications while approaching narrow bridges and haptic exploration at the edge of the bridge. Results confirm predictions about the sequential, ramping‐up process of exploration and the distinct roles of vision and touch. Exploration, however, was not a guarantee of adaptive decisions. With walking experience, exploratory behaviors became increasingly efficient and infants were better able to interpret the resulting perceptual information in terms of whether it was safe to walk.
Optimizing dialysate potassium
Authors: Lee Jennifer , Mendelssohn David C. 
Published: May 2016

AbstractPotassium shifts in thrice weekly HD patients are likely a reversible cause of arrhythmia and sudden cardiac death. In general, a dialysate potassium <2.0 mmol/L should be avoided, and many patients with dialysate potassium of 2 mmol/L could safely be adjusted upwards. The ideal predialysis serum potassium should be around 5.0 mmol/L. Trends in serum potassium and not single values, should inform chronic changes of dialysate potassium prescription. Atypical values should be dealt with as a one off, but should not lead to chronic bath changes. Referral to a renal dietician for counseling to limit dietary potassium intake is vital to prevent recurrence of these atypical episodes. Finally, facilities should develop and implement a formal and reliable way to alert the physician about possible potassium bath mismatching. This facility level approach works best if a policy is developed and endorsed by all involved stakeholders.
Incentives versus insurance in the design of tax‐financed unemployment insurance
Authors: Andersen Torben M. 
Published: May 2016

AbstractThe distortions of job‐search incentives caused by unemployment benefits and their financing are well known. However, a benefit‐tax scheme also provides insurance having direct utility effects as well as indirect effects on risk taking. The latter mitigates or may even dominate standard incentive effects to produce a non‐monotone relation between efficiency (incentives) and equity (insurance). An increase in benefits (and thus tax rate) may up to some point increase average income and reduce inequality. However, optimal utilitarian policies always position the economy at a point where marginal policy changes involve a trade‐off, otherwise policies would not be optimal.
Arms build‐up and arms race in optimal economic growth
Authors: Larrosa Juan M. C. 
Published: May 2016

AbstractI analyze a model of strategic interdependence between two economies linked by investments in defensive capital for deterrence purposes. I adapt a two‐agent dynamic setting where weapon production affects consumption. Individually both economies determine their balanced growth path by taking this interdependence into account in different grades of awareness. I associate two types of equilibria with internal or external determinants for defense production analogous to scenarios of arms build‐up or arms race. I find that a defense sector is compatible with economic growth but a tight arms race can harm growth.
Challenging passivity in venous leg ulcer care – the ABC model of management
Authors: Harding Keith 
Published: May 2016

AbstractThe under‐utilisation of compression for venous leg ulcer (VLU) management translates into lost opportunities to heal wounds, improve patients' quality of life and maximise health care system efficiency. Although compression therapy is considered gold standard according to clinical guidelines, lack of clinician knowledge, unclear referral pathways, local unavailability of compression and patient unwillingness to receive compression, amongst other reasons, mean many candidates for compression do not receive appropriate treatment. This article presents a solution in the form of the ‘ABC model of VLU management, a simplified approach that challenges passivity in the current approach to VLU treatment and supports wider adoption of appropriate compression therapy systems.
Contact allergy to rubber accelerators remains prevalent: retrospective results from a tertiary clinic suggesting an association with facial dermatitis
Authors: Schwensen J.F. , Menné T. , Johansen J.D. , Thyssen J.P. 
Published: May 2016

AbstractIntroductionChemicals used for the manufacturing of rubber are known causes of allergic contact dermatitis on the hands. Recent European studies have suggested a decrease in thiuram contact allergy. Moreover, while an association with hand dermatitis is well established, we have recently observed several clinical cases with allergic facial dermatitis to rubber.ObjectivesTo evaluate temporal trends of contact allergy to rubber accelerators from the European baseline series in a tertiary patch test clinic in Denmark, and examine associations with anatomical locations of dermatitis.MethodsPatch test and clinical data collected in a Danish tertiary dermatology clinic in Gentofte, Herlev, Copenhagen between 1 January 2005 and 31 December 2014 were analysed. The following rubber accelerators or mixtures in petrolatum from the European baseline patch test series were included: thiuram mix 1.0%, mercaptobenzothiazole 2.0% and mercapto mix 1.0%.ResultsThe overall prevalence of contact allergy to rubber accelerators was 3.1% with no significant change during the study period (Ptrend = 0.667). Contact allergy to thiuram mix was the most prevalent and was significantly associated with occupational contact dermatitis, hand dermatitis, age >40 years and facial dermatitis in adjusted binary logistic regression analysis. Current clinical relevance of contact allergy to thiuram mix was 59.3%. Patients with contact allergy to mercapto mix and mercaptobenzothiazole had a concomitant reaction to thiuram mix in 35.2% (19/54) and 35.4% (17/48) of the cases respectively.ConclusionContact allergy to rubber accelerators remains prevalent. Clinicians should be aware of the hitherto unexplored clinical association with facial dermatitis.
N‐Acetylcysteine in the treatment of trichotillomania: remarkable results in two patients
Authors: Özcan D. , Seçkin D. 
Published: May 2016

AbstractBackgroundThe management of trichotillomania is challenging. The limited efficacy and side‐effects of pharmacological medications and difficulty in long‐term maintenance of behavioural therapies necessitates alternative treatment options. A dysregulated glutamatergic system has been implicated in the pathophysiology of trichotillomania. A limited number of reports indicate that N‐acetylcysteine (NAC), a glutamate modulator, may be a promising treatment for this disorder.ObjectivesWe report two patients with trichotillomania for whom treatment with NAC was successful.MethodsThe first patient was a 30‐year‐old female, and the second patient was a 14‐year‐old girl, both who were diagnosed with trichotillomania and prescribed NAC (1200 mg/d, p.o.).ResultsHair pulling behaviour subsided within 2 months and 2 weeks of initiating NAC in the first and second patient, respectively. Complete hair regrowth was observed after 4 and 6 months of NAC treatment in the first and second patient, respectively. No side‐effects related to NAC were noted.ConclusionNAC could be a well‐tolerated and effective treatment option for trichotillomania.
Clinical Nurse Leader Integrated Care Delivery to Improve Care Quality: Factors Influencing Perceived Success
Authors: Bender Miriam , Williams Marjory , Su Wei , Hites Lisle 
Published: May 2016

AbstractPurposeClinical nurse leaderTM (CNL)‐integrated care delivery is a new model for organizing master's‐level nursing clinical leadership at the microsystem level. While there is growing evidence of improved patient care quality and safety outcomes associated with CNL practice, organizational and implementation characteristics that influence CNL success are not well characterized. The purpose of this study was to identify organization and implementation factors associated with perceived success of CNL integration into microsystem care delivery models.MethodsA survey was developed and administered to a nationwide sample of certified CNLs and managers, leaders, educators, clinicians, and change agents involved in planning or integrating CNLs into a health system's nursing care delivery model. Items addressed organizational and implementation characteristics and perceived level of CNL initiative success. Generalized linear modeling was used to analyze data.ResultsThe final sample included 585 respondents. The final model accounted for 35% of variance in perceived CNL initiative success, and included five variables: phase of CNL initiative, CNL practice consistency, CNL instructor or preceptor involvement, CNL reporting structure, and CNL setting ownership status.ConclusionsCNL initiative success is associated with modifiable organizational and implementation factors.Clinical RelevanceStudy findings can be used to inform the development of successful implementation strategies for CNL practice integration into care delivery models to improve care quality outcomes.
A Comparative Study of the Accuracy of Dies Made from Digital Intraoral Scanning vs. Elastic Impressions: An In Vitro Study
Authors: Serag Mahmoud , Nassar Talal al , Avondoglio Dane , Weiner Saul 
Published: May 2016

AbstractPurposeTo compare the dimensional accuracy of dies generated from digital intraoral scans with dies generated from conventional polyvinyl siloxane (PVS) impression material.Materials and MethodsA machined metal die was impressed 10 times using PVS, and scanned 10 times using the iTero Cadent system and 10 times using the LAVA C.O.S. system. Dies generated from each system were imaged in a standardized holder using a microscope and measured with analytical software at three sites and compared with the dimensions of the master die.ResultsThe dimensional differences between the master die and both the PVS and iTero groups were approximately 60 μm in all three dimensions but the Lava C.O.S. die dimensions measured close to 100 μm at two of the three sites.ConclusionPVS/Die and iTero groups offered superior reproduction of the master die in terms of dimensional accuracy, but these differences are likely of little clinical significance.
Japanese History of the Psychology of Fine Arts and Aesthetics
Authors: Arakawa Ayumu 
Published: May 2016

AbstractIn this paper we discuss the history of Japanese psychology of fine arts and aesthetics across five distinct periods: (a) the first expansion of arts psychology research (1907–1932); (b) children's drawings and Gestalt psychology (approximately 1932–1947); (c) the second expansion of arts psychology research, the psychoanalysis of art and art as a target for Gestalt and social psychology (1948–1967); (d) art therapy and the psychology of aesthetics using the semantic differential method and factor analysis (approximately 1968–1996); and (e) the third expansion of arts psychology research, Kansei and neuroaesthetics (1996–). Japanese arts psychology has been altered by the reformation of the discipline, and by the implementation of new methods and theories from overseas. The research targets, such as traditional arts (calligraphy, rock gardens, etc.) and pop culture (“Kawaii,” “Hello Kitty,” etc.), have appeared as Japanese original contributions to the psychology of the arts.
Porphyromonas gingivalis‐induced production of reactive oxygen species, tumor necrosis factor‐α, interleukin‐6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1
Authors: Damgaard C. , Kantarci A. , Holmstrup P. , Hasturk H. , Nielsen C. H. , Van Dyke T. E. 
Published: May 2016

Background and ObjectivesPorphyromonas gingivalis is regarded as a significant contributor in the pathogenesis of periodontitis and certain systemic diseases, including atherosclerosis. P. gingivalis occasionally translocates from periodontal pockets into the circulation, where it adheres to red blood cells (RBCs). This may protect the bacterium from contact with circulating phagocytes without affecting its viability.Material and MethodsIn this in vitro study, we investigated whether human peripheral blood neutrophils from 10 subjects with localized aggressive periodontitis (LAgP) and 10 healthy controls release the proinflammatory cytokines interleukin (IL)‐6, tumor necrosis factor α (TNF‐α), the chemokine (C‐X‐C motif) ligand 8 (CXCL8; also known as IL‐8) and chemokine (C‐C motif) ligand 2 (CCL2; also known as monocyte chemotactic protein‐1) and intracellular reactive oxygen species (ROS) in response to challenge with P. gingivalis. In addition, the impact of RBC interaction with P. gingivalis was investigated. The actions of resolvin E1 (RvE1), a known regulator of P. gingivalis induced neutrophil responses, on the cytokine and ROS responses elicited by P. gingivalis in cultures of neutrophils were investigated.ResultsUpon stimulation with P. gingivalis, neutrophils from subjects with LAgP and healthy controls released similar quantities of IL‐6, TNF‐α, CXCL8, CCL2 and intracellular ROS. The presence of RBCs amplified the release of IL‐6, TNF‐α and CCL2 statistically significant in both groups, but reduced the generation of ROS in the group of healthy controls, and showed a similar tendency in the group of subjects with LAgP. RvE1 had no impact on the production of intracellular ROS, TNF‐α, IL‐6, CXCL8 and CCL2 by neutrophils from either group, but tended to reduce the generation of ROS in subjects with LAgP in the absence of RBCs.ConclusionsOur data support that binding to RBCs protects P. gingivalis from ROS and concomitantly enhances neutrophil release of proinflammatory cytokines providing a selective advantage for P. gingivalis growth.