bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevance, Risks, and Benefits of Early‐Phases Clinical Trials Participations for Patients With Hematological Malignancies From 2008 to 2023
Authors: Guerra Matteo , Alouani Emily , Hueso Thomas , Ouali Kaissa , Danu Alina , Hollebecque Antoine , Bahleda Rastislav , Willekens Christophe , Gazzah Anas , Baldini Capucine , Postel‐Vinay Sophie , Micol Jean‐Baptiste , Massard Christophe , De Botton Stéphane , Ribrag Vincent , Michot Jean‐Marie 
Published: September 2024

ABSTRACTBackgroundEarly‐phases clinical trials (Phases 1 and 2) have evolved from a traditional assessment of toxicity to an adaptive approach based on patients' medical needs and access to effective new therapies. The global risks, benefits, and relevance of early‐phases clinical trials participation for patients with hematological malignancies remain poorly evaluated.Patients and MethodsAll early‐phases clinical trials participations for patients with hematological malignancies, from 2008 to 2023, in a tertiary academic center in Europe, were reviewed. Patient's demographics, tumor type categories, therapeutic responses, mortality, overall survival (OS), and investigational product (IP) were assessed.ResultsOver the period 2008–2023, 736 patients participating in 92 different early‐phases clinical trials, were analyzed. The most common tumor categories were diffuse large B‐cell lymphoma (n = 253; 34.4%), acute myeloid leukemia/myelodysplastic syndrome (n = 164; 22.3%) and multiple myeloma (n = 100; 13.6%). The median OS was 14.8 (95% CI: 12.4–17.9) months and response rate 31.9%, including complete responses in 13.5% of patients. By tumor categories, the highest and lowest median duration of OS were observed for patients with Hodgkin lymphoma (99.8; [95% CI: 47.0‐not reached] months) and peripheral T‐cell lymphoma (8.9 [95% CI: 5.3–12.0] months), respectively. The on‐protocol and treatment‐related mortality rates were 5.43% and 0.54%, respectively. Overall response rate was 29.1% including 13.5% of complete response. Overall, 202 (27.5%) patients received an IP later approved by the health authorities, and those patients had better OS (18.2 months vs. 12.1 months HR: 1.160 [95% CI; 0.6977–1.391], p = 0.0283).ConclusionIn conclusion, patients with hematologic malignancies who have participated in early‐phases clinical trials over the past 15 years have achieved variable therapeutic response rates, acceptable risk/benefit ratio and potentially significant therapeutic advantages. This study provides framework material for hematologists to further discuss clinical trial participation with their patients.
Exploring the role of help‐seeking behavior, family financial socialization, and capability on financial well‐being
Authors: Zhang Yu , Qi Jia , Chatterjee Swarn 
Published: September 2024

AbstractObjectiveThis study develops a conceptual framework for examining the associations between family financial socialization and financial capability on individuals' financial well‐being and explores the mediating role of financial help‐seeking when determining financial well‐being.BackgroundIndividuals' family financial socialization and financial capability are associated with their financial well‐being. This study extends the literature by examining whether seeking financial help can indirectly mediate the association between these factors and individuals' financial well‐being.MethodThis study used the 2016 National Financial Well‐Being Survey data set, consisting of 6,394 adults, and employed structural equation modeling with full information maximum likelihood and bootstrap estimation for empirical analyses.ResultsFinancial knowledge and perceived financial capability were positive contributors to financial well‐being. Family financial socialization showed positive direct and mixed indirect effects on help‐seeking behaviors. When mediated by help‐seeking behaviors, family financial socialization had significantly positive total and indirect associations and a negative direct association with financial well‐being.ConclusionThis study found that financial help‐seeking behavior was a significant factor in the indirect association between family financial socialization, financial knowledge, and well‐being.ImplicationsProviding access to professional advice and encouraging family finance discussions can enhance people's financial well‐being.
Mainstreaming sustainability through sustainability offices: Modes and mechanisms in Swiss cantonal administrations
Authors: Bornemann Basil , Christen Marius 
Published: September 2024

AbstractPublic administrations must change toward sustainability to play a meaningful role in sustainable policy‐making. However, little is known about how and why sustainability‐oriented change unfolds in public administrations. This article aims to advance conceptual and empirical knowledge by examining sustainability mainstreaming through sustainability offices (SO) as a specific type of sustainability‐oriented administrative change. Based on a framework that distinguishes modes and mechanisms of mainstreaming, the article provides qualitative insights into how SO in five Swiss cantons shape the work of their respective administrations toward sustainability. The case comparison suggests that sustainability mainstreaming is most transformative when committed SO address a combination of institutional, ideational, and agency‐related factors through their activities. These findings highlight the critical role of SO in sustainability‐oriented administrative change and lay the groundwork for developing targeted strategies to enhance their effectiveness in mainstreaming sustainability.
What Australia must do to create a climate‐responsive health system
Authors: Smith Carolynn L. , Rojas Christina , Zurynski Yvonne , Partington Andrew , Braithwaite Jeffrey 
Published: September 2024

AbstractCOP‐28, the United Nations' Climate Change Conference, hosted by the United Arab Emirates, ended on 12 December 2023. At the convention, Australia released its National Health and Climate Strategy, committing to low‐carbon, climate‐responsive care. The Strategy will need new policies, projects and investments and a fit‐for‐purpose health workforce. This is a tall order considering healthcare's challenges. Everyone has a role, including clinicians, healthcare agencies, policymakers, politicians, patients and the providers and manufacturers in the supply chain. Clinicians' groups, policymakers and federal and state departments of health have an opportunity to lead climate change reform by considering climate change impacts across clinical practice and health policy.
Selection of Wheat (Triticum aestivum L.) Genotypes Using Yield Components, Water Use Efficiency and Major Metabolites Under Drought Stress
Authors: Mutanda Maltase , Figlan Sandiswa , Chaplot Vincent , Madala Ntakadzeni Edwin , Shimelis Hussein 
Published: September 2024

ABSTRACTIntegrating grain yield, component traits and metabolite profiles aids in selecting drought‐adapted and climate‐smart crop varieties preferred by end users. Understanding the trends and magnitude of grain‐based metabolites is vital for selecting wheat genotypes with higher grain yield, drought tolerance, water use efficiency and product profiles. The aim of this study was to determine the response of newly developed wheat genotypes for grain yield and component traits and metabolites under drought stress to guide selection. One hundred wheat genotypes were preliminarily evaluated for agro‐morphological traits and water use efficiency under drought‐stressed and non‐stressed conditions during the 2022 and 2023 growing seasons using a 5 × 20 alpha lattice design with two replications. Ten high‐yielding genotypes were selected based on grain yield and were validated for agronomic traits and water use efficiency (WUE), and grain samples were assayed to profile their key metabolites under drought‐stressed conditions. Significant differences existed (p < 0.05) among the tested wheat genotypes for yield and yield components, WUE, drought tolerance and major metabolites to discern trait associations. The grain yield of the 10 genotypes ranged from 590.00 g m−2 (genotype LM70 × BW140) to 800.00 g m−2 (BW141 × LM71) under drought‐stressed treatment, whilst under non‐stressed it ranged from 760.06 g m −2 (LM70 × BW140) to 908.33 g m−2 (LM71 × BW162). Grain yield‐based water use efficiency of the assessed genotypes was higher under non‐stressed (0.18 g mm−1) than drought‐stressed (0.17 g mm−1) conditions. The highest drought tolerance index (211.67) and stress susceptibility index (0.77) were recorded for BW162 × LM71, whilst the lowest tolerance index (23.33) and stress susceptibility index (0.09) were recorded in BW141 × LM71. Grain metabolites, including the apigenin‐8‐C‐glucoside (log2Fold = 3.00) and malate (log2Fold = 3.60) were present in higher proportions in the high‐yielding genotypes (BW141 × LM71 and LM71 × BW162) under drought‐stressed conditions, whilst fructose (log2Fold = −0.50) and cellulose (log2Fold = −3.90) showed marked decline in the two genotypes. Based on phenotypic and metabolite profile analyses, genotypes BW141 × LM71 and LM71 × BW162 were selected for being drought‐tolerant, water‐use efficient and recommended for production or breeding. The findings revealed associations between yield components, water use efficiency and grain metabolites to guide the selection of best‐performing and drought‐tolerant wheat varieties.
Multikernel similarity‐based clustering of amorphous systems and machine‐learned interatomic potentials by active learning
Authors: Shuaib Firas , Ori Guido , Thomas Philippe , Masson Olivier , Bouzid Assil 
Published: September 2024

AbstractWe present a hybrid similarity kernel that exemplifies the integration of short‐ and long‐range descriptors via the use of an average kernel approach. This technique allows for a direct measure of the similarity between amorphous configurations, and when combined with an active learning (AL) spectral clustering approach, it leads to a classification of the amorphous configurations into uncorrelated clusters. Subsequently, a minimum size database is built by considering a small fraction of configurations belonging to each cluster and a machine learning interatomic potential (MLIP), within the Gaussian approximation scheme, is fitted by relying on a Bayesian optimization of the potential hyperparameters. This step is embedded within an AL loop that allows to sequentially increase the size of the learning database whenever the MLIP fails to meet a predefined energy convergence threshold. As such, MLIP are fitted in an almost fully automatized fashion. This approach is tested on two diverse amorphous systems that were previously generated using first‐principles molecular dynamics. Accurate potentials with less than 2 meV/atom root mean square energy error compared to the reference data are obtained. This accuracy is achieved with only 175 configurations sampling the studied systems at various temperatures. The robustness of these potentials is then confirmed by producing models with several thousands of atoms featuring a good agreement with reference ab initio and experimental data.
Emergency clinicians' use of adult and paediatric sepsis pathways: An implementation redesign using the behaviour change wheel
Authors: Munroe Belinda , Hudoba Michelle , Fullick Mary , Couttie Tracey , Makoni Hughes , Butina Ellie , Ghosh Niladri , Kloger Ryan , Balzer Sharyn , Middleton Rebekkah 
Published: September 2024

AbstractAimsTo identify facilitators and barriers and tailor implementation strategies to optimize emergency clinician's use of adult and paediatric sepsis pathways.DesignA qualitative descriptive study using focus group methodology.MethodsTwenty‐two emergency nurses and ten emergency medical officers from four Australian EDs participated in eight virtual focus groups. Participants were asked about their experiences using the New South Wales Clinical Excellence Commission adult and paediatric sepsis pathways using a semi‐structured interview template. Facilitators and barriers to use of the sepsis pathways were categorized using the Theoretical Domains Framework. Tailored interventions were selected to address facilitators and barriers, and a re‐implementation plan was devised guided by the Behaviour Change Wheel.ResultsThirty‐two facilitators and 58 barriers were identified corresponding to 11 Theoretical Domains Framework domains. Tailored strategies were selected to optimize emergency clinicians' use of the sepsis pathways including refinement of existing education and training programmes, modifications to the electronic medical record system, introduction of an audit and feedback system, staffing strategies and additional resources.ConclusionThe implementation of sepsis pathways in the Emergency Department setting is complex, impacted by a multitude of factors requiring tailored strategies to address facilitators and barriers and optimize uptake.Implications for Patient CareThis study presents a theory‐informed systematic approach to successfully implement and embed adult and paediatric sepsis pathways into clinical practice in the Emergency Department.ImpactOptimizing uptake of sepsis pathways has the potential to improve sepsis recognition and management, subsequently improving the outcome of patients with sepsis.Reporting MethodThe Consolidated Criteria for REporting Qualitative research guided the preparation of this report.Patient or Public ContributionNil.
How the Approaches of Managing Conflict With Patients Affect Nurse Emotional Exhaustion and Life Satisfaction: A Time‐Lagged Three‐Wave Survey
Authors: Luo Weijia , Wang Jessie Lin , Chen Tingting , Zhu Yue , Wang Jie , Zhou Liping , Zhuang Yiyu 
Published: September 2024

ABSTRACTAim(s)To explore whether nurses' use of different approaches to manage patient mistreatment can exert distinctive effects on their emotional exhaustion and life satisfaction, and to examine whether supervisor support can mitigate the negative effects of emotional exhaustion on nurses' life satisfaction.DesignA time‐lagged three‐wave survey study with a 2‐week time interval was conducted in 2022.MethodsA total of 257 nurses from a Joint Commission International (JCI) accredited general hospital located in eastern China in 2022 completed three‐wave surveys. Descriptive analyses, confirmatory factor analyses and mediation and moderated mediation analyses were performed.Data SourcesData were collected by using three‐wave self‐reported questionnaires from 257 nurses from a Joint Commission International (JCI) accredited general hospital located in eastern China in 2022.ResultsNurses who managed patient mistreatment more cooperatively experienced lower levels of emotional exhaustion, whereas those who managed patient mistreatment more competitively experienced higher levels of emotional exhaustion. Emotional exhaustion was negatively related to life satisfaction. Moreover, emotional exhaustion mediated the positive and negative relationships between cooperative and competitive conflict management approaches and overall life satisfaction. Additionally, supervisor support mitigated the negative impact of emotional exhaustion on life satisfaction and the indirect effects of conflict management approaches on life satisfaction.ConclusionTo effectively manage the negative impact of patient mistreatment on nurses, both nurses themselves and their supervisors play an important role. Nurses who adopt a cooperative conflict management approach experience lower levels of emotional exhaustion and higher levels of life satisfaction. Supervisor support can alleviate the negative effect of emotional exhaustion on life satisfaction.Implications for the Profession and/or Patient CareThe findings provide a better understanding for nurses on how to mitigate the detrimental effects of patient mistreatment on nurses and highlight the role of both nurses themselves and their supervisors in protecting nurses' well‐being.Patient or Public ContributionNo patient or public contributed to the design or conduct of the study, analysis or interpretation of the data, or in the preparation of the manuscript.
Effects of Dignity Therapy on Dignity, Anxiety, Depression and Quality of Life for People With Burns: A Randomised Controlled Trial
Authors: Deng YunYun , Yao YiMing , Wang Chang , Li Ting , Wang Yuan , Kang ChanJuan , Tan HuiYi 
Published: September 2024

ABSTRACTAimsTo evaluate the effect of dignity therapy on dignity, anxiety, depression and overall quality of life for people with burns.DesignA single‐blind, double‐arm, parallel randomised controlled study.MethodsThe Patient Dignity Scale, Hospital Anxiety and Depression Scale, and Burn‐Specific Health Scale‐Short were employed to assess the dignity, anxiety, depression and overall quality of life for people with burns. These outcome indicators were measured and analysed at baseline, 2‐, 4‐ and 8‐week follow‐up. The generalised estimating equations were used to analyse the effect of the intervention during each time point.ResultsA total of 99 participants were recruited (50 in the intervention group and 49 in the control group), with a high retention rate of 97 participants (94.95%) completing the 8‐week follow‐up. All outcome measurement tools met the feasibility criteria related to completeness and responsiveness over time. Dignity was the primary outcome measure, with anxiety, depression and quality of life serving as secondary outcome measures. At the 8‐week post‐intervention, participants in the intervention group demonstrated a statistically significant decrease in dignity and anxiety and depression, and a statistically significant increase in burn‐specific health.ConclusionsDignity therapy can effectively reduce the loss of dignity, anxiety and depression, and improve the quality of life for people with burns. This study has a positive impact on burn dignity nursing practice and provides healthcare professionals with a novel approach to help people with burns return to normal social life with dignity.Implications for the ProfessionIt is important to develop patient‐centred care for burns with dignity. Focusing on developing a rational understanding of non‐discriminatory dignity care practices among clinical providers and to develop dignity‐oriented clinical care practices on the wards.ImpactThis study validated the feasibility of implementing dignity therapy for people with burns. Dignity therapy is effective in reducing the degree of dignity impairment, reducing anxiety and depressive symptoms, and enhancing the quality of life for people with burns. Our findings can help healthcare professionals to provide personalised dignity care throughout the patient's journey to facilitate a dignified reintegration into society and life for people with burns.Reporting MethodThis randomised controlled trial used the CONSORT guidelines.Patient or Public ContributionNo patients or members of the public participated in the study design, data analysis or interpretation.Clinical TrialsThis study has been registered in the Chinese Clinical Trial Registry registration number: ChiCTR2200065145, 29 October 2022.
Role of the mechanotransductor PIEZO1 in megakaryocyte differentiation
Authors: Demagny Julien , Poirault‐Chassac Sonia , Ilsaint Damtz Nehemie , Marchelli Aurore , Gomila Cathy , Ouled‐Haddou Hakim , Collet Louison , Le Guyader Maïlys , Gaussem Pascale , Garçon Loïc , Bachelot‐Loza Christilla 
Published: September 2024

AbstractFrom haematopoietic stem cells to megakaryocytes (Mks), cells undergo various mechanical forces that affect Mk differentiation, maturation and proplatelet formation. The mechanotransductor PIEZO1 appears to be a natural candidate for sensing these mechanical forces and regulating megakaryopoiesis and thrombopoiesis. Gain‐of‐function mutations of PIEZO1 cause hereditary xerocytosis, a haemolytic anaemia associated with thrombotic events. If some functions of PIEZO1 have been reported in platelets, few data exist on PIEZO1 role in megakaryopoiesis. To address this subject, we used an in vitro model of Mk differentiation from CD34+ cells and studied step‐by‐step the effects of PIEZO1 activation by the chemical activator YODA1 during Mk differentiation and maturation. We report that PIEZO1 activation by 4 μM YODA1 at early stages of culture induced cytosolic calcium ion influx and reduced cell maturation. Indeed, CD41+CD42+ numbers were reduced by around 1.5‐fold, with no effects on proliferation. At later stages of Mk differentiation, PIEZO1 activation promoted endomitosis and proplatelet formation that was reversed by PIEZO1 gene invalidation with a shRNA‐PIEZO1. Same observations on endomitosis were reproduced in HEL cells induced into Mks by PMA and treated with YODA1. We provide for the first time results suggesting a dual role of PIEZO1 mechanotransductor during megakaryopoiesis.
Beyond biomarkers: Exploring the diverse potential of a novel phosphoprotein in lung cancer management
Authors: Rostami Amirabbas , Ranjbar Ehsan , Amiri Somayeh , Ezzatifar Fatemeh 
Published: September 2024

AbstractIn addressing the challenges of lung cancer, attention has increasingly turned to molecular diagnostics and targeted therapies, with nucleolin (NCL) assuming a pivotal role, especially in non‐small cell lung cancer. The aberrant activity and cellular distribution of NCL act as crucial biomarkers for early detection and treatment monitoring, showing a strong correlation with disease progression and patient prognosis. Elevated NCL levels signal advanced disease and poorer outcomes, underscoring its significance in evaluating disease severity and therapeutic response. Strategies targeting the molecular interactions of NCL have spurred innovative approaches to inhibit tumour growth, overcome drug resistance and improve treatment efficacy. These advancements are paving the way for personalized therapies tailored to the unique molecular profiles of patients' tumours. Consequently, NCL stands at the forefront of lung cancer management, symbolizing the move towards more precise and individualized oncology care, and marking substantial progress in therapeutic development.
Temperature‐dependent alterations in the proteome of the emergent fish pathogen Edwardsiella piscicida
Authors: Jacobsen Kim L. , Griffin Matt , Phinney Brett S. , Salemi Michelle , Yazdi Zeinab , Balami Sujita , Older Caitlin E. , Soto Esteban 
Published: September 2024

AbstractEdwardsiella piscicida is an emerging bacterial pathogen and the aetiological agent of edwardsiellosis among cultured and wild fish species globally. The increased frequency of outbreaks of this Gram‐negative, facultative intracellular pathogen pose not only a threat to the aquaculture industry but also a possible foodborne/waterborne public health risk due to the ill‐defined zoonotic potential. Thus, understanding the role of temperature on the virulence of this emerging pathogen is essential for comprehending the pathogenesis of piscine edwardsiellosis in the context of current warming trends associated with climate change, as well as providing insight into its zoonotic potential. In this study, significant temperature‐dependent alterations in bacterial growth patterns were observed, with bacterial isolates grown at 17°C displaying higher peak growth sizes, extended lag times, and slower maximal growth rates than isolates grown at 27or 37°C. When E. piscicida isolates were grown at 37°C compared to 27 and 17°C, mass spectrometry analysis of the E. piscicida proteome revealed significant downregulation of crucial virulence proteins, such as Type VI secretion system proteins and flagellar proteins. Although in vivo models of infection are warranted, this in vitro data suggests possible temperature‐associated alterations in the virulence and pathogenic potential of E. piscicida in poikilotherms and homeotherms.