bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sildenafil as Bridge Therapy for Inhaled Nitric Oxide in Preterm Neonates
Authors: Khawaja Harris , Sanders Timothy A. , Schreiber Michael , Bondi Deborah , Shah Pooja , Brennan Gillian 
Published: October 2024

OBJECTIVE
Inhaled nitric oxide (iNO) is a mainstay of treatment for infants with persistent pulmonary ­hypertension. However, abrupt discontinuation of inhaled nitric oxide can result in rebound pulmonary ­hypertension. The objective of this analysis is to describe the use of sildenafil to facilitate the weaning from iNO in preterm neonates.

METHODS
This retrospective chart review identified all infants who were receiving iNO and subsequently received sildenafil between 2017 and 2021. Neonates were included if they met the following criteria: gestational age at birth less than 34 weeks, receiving iNO, and started on sildenafil with the indication to facilitate weaning or discontinuation of iNO. Patients were excluded if they had major congenital anomalies, including congenital heart disease or congenital diaphragmatic hernia.

RESULTS
We identified 7 neonates with a gestational age range of 22 5/7 weeks to 31 0/7 weeks and birth weight range of 545 to 910 g with previously failed attempts at iNO weaning. The most common starting dose for sildenafil was 0.125 mg/kg intravenously every 8 hours or 0.25 mg/kg enterally every 8 hours. Four infants were able to discontinue iNO within 48 hours of sildenafil initiation, 1 patient discontinued iNO within 5 days, and 1 patient within 10 days of sildenafil initiation. One patient experienced weaning failure from iNO despite initiation of sildenafil. No adverse events, such as hypotension or deaths, were reported in any of the 7 infants.

CONCLUSIONS
Sildenafil facilitated weaning off iNO in most preterm neonates evaluated without adverse side effects.
Assessing the Risk of Tuberculosis Relapse Development during the Period of Stabilization of the COVID-19 Epidemic
Authors: Vershinina M. V. , Shevchenko A. I. , Ludanny R. I. , Vorobieva T. I. , Baronova O. D. 
Published: October 2024

The objective: to evaluate risk factors for tuberculosis relapse development during stabilization of the COVID-19 situation.Subjects and Methods. 165 patients over 18 years of age were enrolled in the observational comparative study, those patients were followed up due to respiratory tuberculosis relapses in 2021-2023. Risk factors for early and late relapses that occurred during the pandemic (2021-2022) and post-pandemic (2023) periods were analyzed. They included age, gender, accommodation, social status, imprisonment, smoking, alcohol and substances abuse, comorbidities, clinical forms of tuberculosis, presence of cavities, bacterial excretion, and drug resistance of Mycobacterium tuberculosis.Results. The data obtained confirmed the assumption that the COVID-19 pandemic had led to changes in social and medical-biological risk factors for tuberculosis relapse.
Features of Intracellular Matrix State during Development and Formation of COPD Clinical Phenotypes
Authors: Tayutina T. V. , Shlyk S. V. , Kudlay D. A. , Smerdin S. V. , Shovkun L. A. , Kizhevatova E. A. , Nikolenko N. Yu. , Kampos E. D. 
Published: October 2024

The objective: to evaluate state of extracellular matrix markers and their tissue inhibitors during development and formation of clinical phenotypes of COPD, in patients facing the high risk of developing exacerbations.Subjects and Methods. 96 COPD patients (73% men and 27% women) were examined. Patients were randomized into the following groups: Group 1 included 40 COPD patients with bronchitis phenotype; Group 2 included 38 patients with emphysema phenotype; and Control Group consisted of 18 practically healthy subjects. All patients underwent a comprehensive clinical and laboratory examination. Levels of matrix metalloproteinases (total MMP-9 and MMP-2) and their tissue inhibitors TIMMP1 and TIMMP2 were determined by ELISA.Results. The development of COPD, regardless of the clinical phenotype of the disease, is accompanied by pronounced expression of extracellular matrix markers MMP-9 and MMP-2. Regardless of the COPD clinical phenotype, elevated activity of metalloproteinases is accompanied by inhibition of production of TIMMP2 and dysfunction of the MMP-9/TIMMP1 antiprotease system. In COPD patients with MMP-2 level of 214 ng/ml, the formation of bronchitis phenotype can be predicted, while with MMP-2 level of 214 ng/ml or more, the formation of emphysema phenotype can be predicted.
Efektivitas Penggunaan Media Sosial dalam Penyebaran Informasi Publik guna Mencegah Penyebaran Berita Hoax oleh DISKOMINFOS Kota Denpasar
Authors: Devi Komang Triananda Kurnia , Wirantari I Dewa Ayu Putri , Wijaya Komang Adi Sastra 
Published: October 2024

This study aims to evaluate the effectiveness of using social media as a means of public information disclosure services in preventing the spread of hoax news by DISKOMINFOS Denpasar City. The focus of the research is social media managed by the Denpasar City Communication, Information and Statistics Office which consists of 3 indicators, namely goal achievement, integration, and adaptation. This type of research uses descriptive methods with a qualitative approach. Data collection techniques were conducted through interviews, observation and documentation. The results showed that in the indicator of achieving goals, it has been running quite well because it is in accordance with the legal basis and applicable SOPs, good achievement time and community targets as recipients of information. The Integration indicator is not yet said to be optimal because there are still problems such as two-way interaction that has not been maximized, lack of digital literacy and public interest in the information provided. Finally, the Adaptation Indicator can also be said to be quite good in terms of facilities and infrastructure and preparation from employees, but this still has to be improved. The recommendations given aim to optimize the use of social media in disseminating public information such as increasing social interaction and improving the quality of information submitted by the government.
ABSTRAK
Penelitian ini bertujuan untuk mengevaluasi efektivitas penggunaan media sosial sebagai sarana pelayanan keterbukaan informasi publik dalam mencegah penyebaran berita hoax oleh DISKOMINFOS Kota Denpasar. Fokus penelitian adalah media sosial yang dikelola oleh Dinas Komunikasi, Informatika, dan Statistik Kota Denpasar yang terdiri dari 3 indikator yakni pencapaian tujuan, integrasi, dan adaptasi. Jenis penelitian menggunakan metode deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data dilakukan melalui wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa dalam indikator pencapaian tujuan, sudah berjalan cukup baik karena sesuai dengan landasan hukum serta SOP yang berlaku, waktu pencapaian yang baik serta sasaran masyarakat sebagi penerima informasi. Indikator Integrasi belum dikatakan optimal karena masih ada permasalahan seperti interaksi dua arah yang belum maksimal, kurangnya literasi digital dan minat masyarakat terhadap infomasi yang diberikan. Terakhir Indikator Adaptasi juga dapat dikatakan cukup baik dari segi sarana dan prasana serta persiapan dari pegawai, namun hal ini masih harus ditingkatkan. Rekomendasi yang diberikan bertujuan untuk mengoptimalisasi pemanfaatan media sosial dalam penyebaran informasi publik seperti peningkatan interaksi sosial dan peningkatan kualitas informasi yang disampaikan oleh pemerintah.
Kata Kunci: Efektivitas, Media Sosial, Keterbukaan Informasi Publik, Berita Hoax
Peningkatan Kualitas Bacaan Alquran Melalui Metode Talaqqi pada Murid TPQ Desa Landbaw
Authors: Randy Rahma Putra  , Umi Fauziah  , Ulil Albab  , Annisa ‘Ainurrahmatin Najiyah  , Nanda Alhusna  
Published: October 2024

Landbaw Village is situated in Tanggamus Regency's Gisting District. This village created a Quranic Education Park to instill moral principles and Quranic education in children from a young age. A crucial venue for children's character development and formation is the Quranic Education Park (TPQ). From an early age, children are provided with the chance to study and explore the sacred book of the Quran, adhere to Islamic principles, and develop admirable qualities through this establishment. They are given a brief introduction to the Quran, helped to comprehend its lessons, and urged to live their lives in accordance with Islamic principles. The Landbaw village now offers the option to learn using the talaqqi method. With this method, there is direct communication between the between the teacher and the children.
Sertifikasi Halal Produk UMK dalam Meningkatkan Kepercayaan Konsumen
Authors: Winarto Winarto , Hendri Budi Santoso  
Published: October 2024

Era saat ini UMK dituntut menghasilkan produk layak jual didukung dengan produk tersertifikasi halal yang diselenggarakan oleh badan penjamin produk halal. Ini merpakan jaminan kehalalan produk tertentu yang dipasarkan pada konsumen. Produk UMK dituntut memiliki kualitas produk yang terjamin, higienis sesuai dengan standar kehalalan produk dari Majelis Ulama Indonesia. Faktanya Progam SEHATI yang dicanangkan oleh Kementerian Agama RI masih mengalami kesulitan dalam implementasi pendampingan sertifikasi halal kepada pelaku UMK di Indonesia, salah satunya seperti permasalahan yang terjadi di Kabupaten Blitar. Tujuan penelitian, meneliti tingkat kesadaran masyarakat tentang pentingnya kegiatan sertifikasi halal pada produk UMK kerangka meningkatkan nilai produk dan kepercayaan konsumen melalui Program Sehati di Kabupaten Blitar. Metode kualitatif pedekatan fenomenologi digunakan dalam penelitian ini. Teknik pengumpulan data dengan wawancara, observasi, dokumentasi, dan studi pustaka. Hasil penelitian, sosialisasi secara masif dan pendampingan halal malalui program sehati, yakni mengedukasi dan mensosialisasikan pelaku usaha UMK tentang sertifikasi halal, selanjutnya diikuti dukungan kerjasama antara pemerintah daerah dengan pemerintah desa, keikutsertaan perguruan tinggi dalam memberikan pendampingan kepada pelaku UMK. Kemudahan akses mengurus sertifikasi halal oleh pemerintahan daerah dan dinas terkait, adanya sosialisasi program sehati dari pemeritahan desa kepada pelaku usaha, para pendamping halal harus berkolaborasi dengan pusat pelatihan bisnis, meminimalisir adanya praktek pungutan liar dalam pendampingan program sehati, memperbanyak delegasi pendamping halal di desa. Program sertifikasi halal gratis wajib sosialisasi secara masif kepada palaku UMK dengan harapan memberikan berbagai manfaat dalam kemajuan usaha di masa depan.
PERAN GURU PENDIDIKAN AGAMA ISLAM DAN BUDI PEKERTI DALAM MENGATASI KESULITAN BELAJAR SISWA PADA MATERI PENYELESAIAN JENAZAH KELAS XI MIA DI SMA ISLAM AL-AZHAR NW KAYANGAN
Authors: Nasir Muhammad , Hudatullah  
Published: October 2024

Siswa sebagai objek pembelajaran memiliki kompleksivitas yang membutuhkan seperangkat pengetahuan yang mumpuni guna mengerahkan segenap kemampuan dan potensi yang ada dalam diri siswa. Langkah ini dilakukan untuk meminimalisir setiap hambatan yang akan dialami oleh siswa dalam proses pembelajaran khususnya pembelajaran Pendidikan Agama Islam yang berkaitan dengan prosesi penyelenggaraan jenazah. Adapun pendekatan penelitian yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan pengumpulan data menggunakan metode wawancara, observasi dan dokumentasi. Sedangkan analisis datanya menggunakan teknik model Miles dan Huberman. Teknik keabsahan datanya menggunakan Perpanjang Keikutsertaan, Ketekunan/ Keajegan Pengamatan dan Triangulasi (Triangulasi sumber, Triangulasi teknik dan Triangulasi waktu). Adapun hasil penelitian ini adalah: 1) Peran guru dalam mengatasi kesulitan belajar PAI dan Budi Pekerti di SMA Islam Al-Azhar NW Kayangan adalah sebagai motivator yang bisa memotivasi dikala peserta didiknya itu mengalami kesulitan dalam belajar. Selain menjadi motivator guru juga berperan sebagai pembimbing yang bisa membimbingnya ketika peserta didik berbuat salah dan melanggar aturan agama. Di sini peran guru juga sebagai evaluator yaitu menilai peserta didiknya sampai dimana peserta didik itu memahami pelajaran yang telah guru sampaikan. Guru juga berperan sebagai model karena itu guru harus mempunyai sikap yang baik dan bisa dicontoh oleh peserta didiknya dan bernuansa islami dan 2) Kesulitan belajar dalam bidang studi PAI dan Budi Pekerti yang dialami oleh peserta didik di sekolah merupakan penghambat kegiatan belajar, terdapat dua faktor penyebab kesulitan pendidikan agama Islam yaitu faktor dari dalam diri peserta didik (intern) dan faktor dari luar diri peserta didik (ekstern). intern yaitu faktor yang muncul dari dalam peserta didik meliputi peserta didik kurang mampu memahami keterangan yang diberikan dari guru agama, kurangnya motivasi diri untuk belajar serta peserta didik tidak dapat menerapkan materi agama yang diterima di sekolah dalam kehidupan sehari-hari. Faktor penghambat dari faktor ekstern yaitu kurangnya kerjasama antara guru dan orang tua peserta didik serta kemajuan ilmu pengetahuan dan teknologi.
PKM Strategi Digital Marketing Dalam Pemasaran Produk Daun Kelor Pada Home Industry Glamori Meto
Authors: Antonius Andrias Reis Tanesi  
Published: October 2024

In the online era, marketing opportunities using digital technology are very profitable, apart from sellers not having to have a shop, sellers also don't have to go anywhere to sell. The objectives of this activity are (1) Organizing guidance and training for marginalized communities to produce commercial products based on appropriate technology and local resources as well as opportunities to gain access to funding for Micro, Small and Medium Enterprises, (2) Increasing the number of applications of science and technology for the community. This activity was carried out in the first three stages of program socialization and forum group discussion (FGD). The service team planned all the needs that would be used in implementing the service. The service team carried out FGD (Forum Group Discussion) and a cooperation MoU. Second Stage Creating Social Media Accounts Workshop and mentoring on IT knowledge. The third stage of evaluation is carried out to correct any deficiencies found during the service. The main goal is to increase understanding of various social media platforms, effective advertising strategies and ad performance measurement. The method is to use the PKM method with questionnaires and outreach. The results show an increase in home industry players' understanding of the benefits of social media in digital marketing. They are starting to realize the potential of the online market without high advertising costs. This socialization has the potential to increase the application of digital marketing in the home industry. It is recommended that home industry players continue to develop digital marketing capabilities and collaborate to share experiences in managing advertising on social media.
CONSIDERAÇÕES SOBRE O CONSERVADORISMO DE BURKE À LUZ DA SUA OBRA REFLECTIONS ON THE REVOLUTION IN FRANCE
Authors: Lima Leonardo Noro De 
Published: October 2024

The paper investigates the thought of Edmund Burke, trying to understand and giving special attention to the conservative philosophy by which the author underlies within his political philosophy. The research here described focuses especially on the analysis and approach present in the author's edifying work, Reflections on the Revolution in France, and how these approaches have contributed to spread and generate modern conservatism, relying on its approaches as values, such as tradition, defense of order, hierarchy, communitarianism and opposition to rationalism, for the idea of the people assuming power as a fundamental part of a conservative policy, thus against monarchical absolutism, which went against Burke's thought in the sense that power should be dissolved among all, and decision-making exercised taking into account multi-generational events, thus valuing traditions, so that these important ingredients construct Burke's arguments, which remains present in modern conservative thinking.
DIAGNÓSTICO CLÍNICO MOLECULAR DAS SÍNDROMES FEBRIS NA AMAZÔNIA OCIDENTAL: REVISÃO SISTEMÁTICA
Authors: Melo Jose Johnata Paiva de , Soares Carolina Pontes , Lobato Cirley Maria Oliveira 
Published: October 2024

Introdução:As síndromes febris dengue, chikungunya e zika são consideradas arboviroses que podem ser transmitidas pelo mesmo vetor em regiões tropicais e subtropicais do mundo. Objetivo: Este trabalho de pesquisa tem como objetivo pesquisar e descrever sobre as arboviroses, incluindo as classificações e características que implicarão nas sintomatologia desta patologia que possui uma alta incidência no Brasil. Resultados: O Dengue vírus (DENV) e Zika vírus (ZIKV) pertencem ao mesmo gênero Flavivirus, possuem em sua estrutura genômica um RNA envelopado, em sentido positivo e de fita simples. Adicionalmente, o Chikungunya vírus (CHIKV) é um RNA vírus envelopado, em senso positivo e de cadeia simples, pertencente ao gênero Alphavirus. No Brasil o DENV circula desde a década de 80, com surtos anuais facilitado pela circulação de quatro sorotipos (DENV1- 4) com infecções, geralmente, sintomáticas podendo evoluir para manifestações hemorrágicas ou neurológicas fatais. O CHIKV foi inserido em 2014 causando epidemias e surtos, de uma doença debilitante podendo cursar em intensa artralgia, enquanto que o ZIKV ficou bastante conhecido depois do surto brasileiro em 2015, estando associado às consequências mais graves da infecção pelo vírus, com a Síndrome de Guillain-Barré e vários casos registrados de microcefalia em neonatos no surto. No estado do Acre há circulação simultânea dos três vírus, com predominância dos sorotipos DENV1-2, e foram registrados alguns casos de coinfecção. Conclusão: As arboviroses constituem um grave problema de saúde pública nas regiões subtropicais e tropicais por oferecem condições ecológicas favoráveis e apresentarem expressividade em morbidade e/ou mortalidade, sendo necessário estudos que fortaleçam e contribuam para melhoria da qualidade das informações e conscientização da população sobre as arboviroses e suas sintomatologias.
A IMPORTÂNCIA DOS PROJETOS DE EXTENSÃO UNIVERSITÁRIA NO ENSINO TEÓRICO E PRÁTICO NOS CURSOS DA MEDICINA: USO DA FERRAMENTA CONSCIENTIZAÇÃO DA PRÁTICA DE UMA ROTINA SAUDÁVEL PARA PREVENÇÃO DE DOENÇAS.
Authors: Lopes Romário Mascena Amorim , Silva Filho Markinokoff Lima e , Alves Débora Larissa Rufino , Vasconcelos Kleber Vinicius Rodrigues de , Melo Klary Gheorgia Silveira Medeiros , Absalão André Cordeiro de Sousa , Lima Márcio José de Carvalho , Carvalho Louise Santana de , Teixeira Neto João Bosco Antunes , Nascimento Loreanne Gomes , Pereira Suzy Mary Ferreira 
Published: October 2024

RESUMO: A educação nos cursos da área da saúde pode ser compreendida como um conjunto de saberes teóricos passados em sala de aula e práticas em laboratório, sendo ainda possível acumular experiências ainda como acadêmico, para além das horas de estágio regular, por meio de projetos voltados para atender a comunidade, prevenção de doenças e promoção da saúde. (SILVA, et al. 2007; BRITO, 2021). Essas práticas educativas nesta área devem ser direcionadas para o desenvolvimento de capacidades individuais e coletivas visando do acadêmico, bem como para população à melhoria da qualidade de vida e saúde e melhora no autogerenciamento, principalmente quando relacionamos as doenças crônico-degenerativas. (BARROS, CARNEIRO, 2011).OBJETIVOS: Descrever o que é projeto de extensão universitária e os benefícios para o ensino superior, acadêmico e comunidade. METODOLOGIA: Trata-se de uma revisão de literatura em bases indexadas scielo, pubmed, lilacs, utilizando os descritores Formação em saúde; Ensino, Pesquisa e Extensão; Interdisciplinaridade; Humanização do cuidado, Medicina, no período de 2004 a 2024. RESULTADOS E DISCUSSÃO: Os artigos selecionados corroboram com a cerne dessa revisão que a trabalhos em grupos para realizar educação em saúde e favorecer a inter-relação profissional-usuário-família, e resultados positivos em auxiliar os mesmos a enfrentar de forma mais adequada às doenças crônicas e possibilitando o empoderamento de seu autocuidado. (SANTOS. 2011; NOVAES, 2021). CONCLUSÃO:É inquestionável que a Extensão Universitária dispõe de um potencial transformador das estruturas acadêmicas e sociais, uma vez que, as instituições garantem que os discentes obtenham uma formação mais integral, com o devido alinhamento do tripé: Ensino, Pesquisa e Extensão.
Coletânea de Poemas e narrativas autobiográficas
Authors: Sousa Marcia , Caetano Nina , Da Iola Luiza , Sabino Nívea , Gravano Joyce , Mariano Bárbara , Shinzato Batia Jello 
Published: October 2024

Coletânea de Poemas e narrativas autobiográficas. Org: Nina Caetano e Márcia Sousa Autoras convidadas: Luiza da Iola, Nívea Sabino, Joyce Gravano, Bárbara Mariano e Batia Jello (Iyalorixa Sandide). Diagramação: Deyla Dayanne Rabelo Silva.
Optimization of ultrasonic-assisted debittering of Ganoderma lucidum using response surface methodology, characterization, and evaluation of antioxidant activity
Authors: Chen Shuting , Song Shiying , Tan Yumei , He Shengling , Ren Xiyi , Li Zhu , Liu Yongxiang 
Published: October 2024

Background
Ganoderma lucidum (G. lucidum) has gained increasing attention as a potential health care product and food source. However, the bitter taste of G. lucidum has limited its development and utilization for the food industry.

Methonds
The response surface methodology was employed to optimize the inclusion conditions for the debittering of G. lucidum. The effects of 2-hydroxypropyl-β-cyclodextrin concentration (12–14 g/mL), ultrasound temperature (20–40 °C and host—guest ratio (1:1–2:1) on response variables were studied. The physical characteristics of inclusion complexes prepared through spray drying and freeze drying were analyzed. The antioxidant activity of the different treated samples was subsequently investigated.

Results
Study results showed that, in comparison to the control group, the inclusion solution displayed a significantly enhanced taste profile under optimal processing conditions, exhibiting an 80.74% reduction in bitterness value. Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (NMR) studies indicated the successful formation of inclusion compounds. The moisture content and bulk density of spray-dried powder were found to be significantly superior to those of freeze-dried powder (p < 0.05). In comparison to the diluted solution, the inclusion liquid demonstrated a 20.27%, 30.01% and 36.55% increase in ferric ion reducing antioxidant power (FRAP), hydroxyl radical scavenging and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging respectively. Further, the DPPH clearance of microencapsulated powder was not significantly different from that of tocopherol at a concentration of 25 mg/mL.

Conclusions
In summary, the study provides theoretical basis and methodological guidance to eliminate the bitterness of G. lucidum, and therefore provide potential options to the use of G. lucidum as a food source.