bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drought response transcriptomes are altered in poplar with reduced tonoplast sucrose transporter expression
Authors: Xue Liang-Jiao , Frost Christopher J. , Tsai Chung-Jui , Harding Scott A. 
Published: September 2016

AbstractTransgenicPopulus tremulaxalba(717-1B4) plants with reduced expression of a tonoplast sucrose efflux transporter,PtaSUT4, exhibit reduced shoot growth compared to wild type (WT) under sustained mild drought. The present study was undertaken to determine whetherSUT4-RNAi directly or indirectly altered poplar predisposition and/or response to changes in soil water availability. While sucrose and hexose levels were constitutively elevated in shoot organs, expression responses to drought were most altered in the root tips ofSUT4-RNAi plants. Prior to any drought treatment, constitutively elevated transcript levels of abscisic acid biosynthetic genes and bark/vegetative storage proteins suggested altered metabolism in root tips of RNAi plants. Stronger drought-stimulation of stress-inducible genes encoding late-embryogenesis-abundant proteins in transgenic roots was consistent with increased vulnerability to soil drying. Transcript evidence suggested an RNAi effect on intercellular water trafficking by aquaporins in stem xylem during soil drying and recovery. Co-expression network analysis predicted altered integration of abscisic acid sensing/signaling with ethylene and jasmonate sensing/signaling in RNAi compared to WT roots. The overall conclusion is that steepened shoot-root sugar gradient in RNAi plants increased sensitivity of root tips to decreasing soil water availability.
Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure
Authors: Wei Qun , Liu Haiyan , Liu Miao , Yang Chunyan , Yang Jie , Liu Zhonghui , Yang Ping 
Published: September 2016

AbstractPrior studies have shown that overexpression of ACT A can lead to ventricular remodeling in rat models of heart failure. Furthermore, recently work studying demonstrated that stimulation of activin An expression in rat aortic smooth muscle (RASM) cells by angiotensin II (Ang II). Ramipril is a recently developed angiotensin converting enzyme (ACE) inhibitor. To investigate the effects of Ramipril on expression of ACT A-FS, we established the rat model of heart failure after myocardial infarction (MI), and divided into either a sham operation (SO), MI, or MI-Ramipril group. We found that Ramipril significantly attenuates collagen-I and III deposition (col-I and III). Notably, we determined that expression of ACT A and II activin receptor (ActRII) were significantly down-regulated in the non-infarcted area of the left ventricle in the Ramipril group, whereas the mRNA and protein levels of FS were markedly up-regulated. Our data suggested that Ramipril benefited left ventricular remodeling by reducing fibrosis and collagen accumulation in the left ventricle of rats after myocardial infarction. This observation was also associated with down-regulation of ACT A expression. This study elucidated a new protective mechanism of Ramipril and suggests a novel strategy for treatment of post-infarct remodeling and subsequent heart failure.
Nox2 contributes to the arterial endothelial specification of mouse induced pluripotent stem cells by upregulating Notch signaling
Authors: Kang Xueling , Wei Xiangxiang , Wang Xinhong , Jiang Li , Niu Cong , Zhang Jianyi , Chen Sifeng , Meng Dan 
Published: September 2016

AbstractReactive oxygen species (ROS) have a crucial role in stem-cell differentiation; however, the mechanisms by which ROS regulate the differentiation of stem cells into endothelial cells (ECs) are unknown. Here, we determine the role of ROS produced by NADPH oxidase 2 (Nox2) in the endothelial-lineage specification of mouse induced-pluripotent stem cells (miPSCs). When wild-type (WT) and Nox2-knockout (Nox2−/−) miPSCs were differentiated into ECs (miPSC-ECs), the expression of endothelial markers, arterial endothelial markers, pro-angiogenic cytokines and Notch pathway components was suppressed in the Nox2−/− cells but increased in both WT and Nox2−/− miPSCs when Nox2 expression was upregulated. Higher levels of Nox2 expression increased Notch signaling and arterial EC differentiation and this increase was abolished by the inhibition of ROS generation or by the silencing of Notch1 expression. Nox2 deficiency was associated with declines in the survival and angiogenic potency of miPSC-ECs and capillary and arterial density were lower in the ischemic limbs of mice after treatment with Nox2−/− miPSC-ECs than WT miPSC-EC treatment. Taken together, these observations indicate that Nox2-mediated ROS production promotes arterial EC specification in differentiating miPSCs by activating the Notch signaling pathway and contributes to the angiogenic potency of transplanted miPSC-derived ECs.
Komplikationen in der Kniechirurgie des Rheumatikers
Authors: Biehl C. , Thormann U. , Heiß C. 
Published: September 2016

ZusammenfassungIm Langzeitverlauf der Rheumatoiden Arthritis (RA) ist das Kniegelenk nahezu immer in das Krankheitsgeschehen mit einbezogen. Gleichzeitig sind entzündlich destruierte Kniegelenke der häufigste Grund für schwere Beeinträchtigungen der ADL (Verschlechterung der sozialen Teilhabe!!) unserer Patienten. Erschwerend kommt hinzu, dass es gegenüber Komplikationen nach therapeutischen Maßnahmen besonders anfällig ist. Diese Übersicht zeigt mögliche Komplikationen im Zusammenhang mit Interventionen auf und bietet Lösungsansätze. Jede Abteilung, die sich um diese Patienten bemüht, benötigt ein stadienadaptiertes Konzept und perioperatives Management um mögliche Risiken so gering wie möglich zu halten.
Intralingual intertemporal translation as a relevant category in translation studies
Authors: Karas Hilla 
Published: September 2016

AbstractThis article argues for intralingual intertemporal translations as a separate category within the field of translation studies. Not only do these translations seem to have common characteristics and behaviors, but it is precisely their particularities that make them a key to understanding more ‘typical’ translations. Two main sets of examples will serve as demonstration: translations from Old French into Middle and Modern French, and a Modern Hebrew translation of the Old Testament, originally written in Biblical Hebrew, as well as the public discussion following its publication.
Evaluating the implementation performance of a supplier development program
Authors: Routroy Srikanta , Pradhan Sudeep Kumar , Sunil Kumar C.V. 
Published: September 2016

Purpose
The purpose of this paper is to quantify, evaluate and compare the implementation performance of a supplier development (SD) program using graph theoretic approach (GTA).

Design/methodology/approach
Broadly 13 critical success factors (CSFs) were identified and they were classified into four significant categories (SCs). Featuring these SCs and CSFs under each SC, GTA was proposed for evaluating the implementation performance of SD programs. The analysis was further extended to evaluate the performance of a SD program along the timeline to capture the other influences (if any), eventually compare the results with different performance situations and accordingly set the future targets.

Findings
In order to demonstrate the utility of the proposed approach it was applied to an Indian manufacturing company. The results obtained shown that there has been a significant growth achieved in the implementation performance of a SD program over a period of three years (i.e. 12 quarters) along the chosen SCs and CSFs under each SC. It was also found that still there was a performance gap and scope for improvement in the SD program of the case company.

Practical implications
The proposed approach is aimed at providing a procedure for evaluating the implementation performance of a SD program. This study is an attempt to assist a manufacturer to assess its SD program and accordingly define its course of actions.

Originality/value
Although many issues related to SD have been widely recognized and studied, there are no specific studies available in the literature to assess the implementation performance of SD programs along the timeline. The proposed model has the ability to capture the performance and interdependencies of SCs, CSFs under each SC and also to quantify the implementation performance of a SD program along the timeline.
Social stratification, materialism, post-materialism and consumption values
Authors: Wang Ying 
Published: September 2016

Purpose
The increased income and modernity have greatly impacted Chinese consumers’ attitudes and purchasing behavior, making them more sophisticated than ever before. The purpose of this paper is to examine the interrelationship among social stratification, materialism, post-materialism, and consumption values contributing uniquely to understanding Chinese consumers in the context of drastic economic and social changes.

Design/methodology/approach
Survey method was used to test the proposed model and answer the research questions. The data were collected in Shanghai, the largest city on the eastern coast of China. A multi-stage random sampling strategy was employed to acquire a representative sample of the population in the city. A total of 2,910 completed questionnaires were used for data analysis.

Findings
The results show that objective social status has a negative effect on post-materialism, whereas subjective social status has a positive effect. Social status does not seem to have a significant effect on materialism. Post-materialism also has a strong positive effect on the consumption orientations of emotional value and social value.

Practical implications
China was chosen as the research context in this study. As a booming emerging market, China provides an intriguing platform to examine social stratification and materialism. At the macro level, China is developing a new social structure due to the drastic social and economic changes. At the individual consumer level, as China moves further into a market-oriented economy, traditional Chinese values have changed rapidly. Western consumption values and phenomena such as overspending and conspicuous consumption have begun to take hold in China, especially among young people. It is critical for business managers to understand the shift of consumption values among Chinese in order to successfully capture this market.

Originality/value
A cursory review of past literature reveals that researchers have examined materialism primarily along two avenues: one puts materialism within a macro framework involving political interest or civic engagement (e.g. Davis et al., 1999; Inglehart, 1990); the other one takes a micro perspective exploring the impact of materialism on consumer attitudes and behavior (e.g. Park and Rabolt, 2009; Xiao and Kim, 2009). However, little research has been conducted linking the two approaches. The present study intends to examine the interrelationship among social stratification, materialism, post-materialism, and consumption values. Hopefully, it will shed some light on the connection between macro environment and micro consumer behavior. Furthermore, the current research provides evidences for the emerging transformation to a post-materialistic marketplace.
Culture and corporate governance convergence
Authors: Ntongho Rachael Ajomboh 
Published: September 2016

PurposeThis paper aims to analyse the link between culture and corporate governance. In particular, it demonstrates the impact of culture in inhibiting convergence of corporate governance. Overall, the paper provides an appraisal of corporate governance laws in stakeholder-oriented states that have endured market pressure for convergence.Design/methodology/approachThe paper utilises historical trend in analyzing changes in corporate governance regulation in six countries covering three continents with stakeholder-oriented corporate governance model to determine the effect of culture in the convergence or divergence of corporate governance.FindingsThe view that corporate governance is converging towards the shareholder model largely ignores cultural differences in states. An appraisal of corporate governance rules and principles that have endured Anglo-American influence reveals a strong propensity for cultural norms to dictate areas where changes occur. This paper demonstrates nominal changes in corporate governance regulation and ideologies, as states still turn to design corporate governance rules around their cultural philosophy. The paper also reveals weak political authority for convergencevis-à-vismarket forces.Practical implicationsLaws are strongly embedded in the corporate philosophies of states. Thus, the market and managers need to incorporate national culture into corporate practices for effective implementation.Originality/valueFew studies have examined the effect of culture on the convergence of corporate governance regulation, especially across different countries. This study does not only analyze corporate governance in developed countries but also examines emerging nations in Africa where research on convergence is very scarce.
Electricity generation as a determinant of unemployment in Pakistan
Authors: Rashid Adnan , Ul Haq Anwaar 
Published: September 2016

Purpose
The area about unemployment and its participation in the economic progress has been widely debated in literature. A significant number of studies on this impediment of economic boom have been found to consider the concept through Okun’s law. This study aims to apply some different approach and re-define the model about determinants of unemployment via inclusion of electricity generation in it. The purpose here for such consideration is the redefinition of determinants to clearly examine the role of each participant in solution of the problem.

Design/methodology/approach
This study for accomplishment of subject matter considers macroeconomic determinants of unemployment and includes electricity generation process in model. Such model is then empirically tested via structural vector autoregression (VAR) and impulse response function.

Findings
The empirical analysis of the study by stating the presence of long-run association comprehend the findings of most of the previously held studies on the subject matter. In addition to such co-integration, the presence of long-run restriction validates the main research question by explaining the negative relationship of GDP and electricity generation with unemployment of the country. Additionally, the responses of impulse function further validate the hypothesis by stating the more response of both electricity generation and GDP than any other variable in elucidating the problem of unemployment.

Research limitations/implications
The main limitation of this study is its restrictive use of electricity generation as a source of power generation. One can use other sources of power generation in addition to electricity generation in the study. Furthermore, this study only applies the concept of macroeconomic variables for getting the solution of problem. Besides macroeconomic factors, a number of microeconomic factors are also present that in addition to above mentioned macroeconomic variables help the policy makers to elucidate the problem.

Originality/value
The originality of this paper lies in its concept about involvement of electricity generation in determinants of unemployment. To date, no such study has been found in existing body of literature that has investigated the problem from this perspective, and, hence, this study represents contribution of authors to the area of literature.
A novel study on OFDI and home country exports: implications for the ASEAN region
Authors: Ahmad Fayyaz , Draz Muhammad Umar , Yang Su-Chang 
Published: September 2016

Purpose
This study aims to examine the effects of outward foreign direct investment (OFDI) on the home country exports for selected ASEAN countries during 1981-2013.

Design/methodology/approach
The authors have used OLS regression based on the unit root analysis, correlation technique and a series of specification tests applied to annual time series data.

Findings
The results reveal that the complementary effects of OFDI on exports of the home country outweigh the substitution effects for four ASEAN countries. Furthermore, trade openness, currency fluctuations and inward foreign direct investment (FDI) are also important factors for progressive home country exports.

Originality/value
This study provides a thorough analysis of the links between OFDI and exports of the home country on a macro level. With a data set of more than three decades from the ASEAN region, this study is the first attempt of its kind to analyze the relationship of these two variables on the aggregate level.
Utilization of a microstructure sensitive fatigue model for additively manufactured Ti-6Al-4V
Authors: Torries Brian , Sterling Amanda J. , Shamsaei Nima , Thompson Scott M. , Daniewicz Steve R. 
Published: September 2016

PurposeThe purpose of this study is to calibrate a microstructure-based fatigue model for its use in predicting fatigue life of additively manufactured (AM) Ti-6Al-4V. Fatigue models that are capable of better predicting the fatigue behavior of AM metals is required to further the adoption of such metals by various industries. The trustworthiness of AM metallic material is not well characterized, and fatigue models that consider unique microstructure and porosity inherent to AM parts are needed.Design/methodology/approachVarious Ti-6Al-4V samples were additively manufactured using Laser Engineered Net Shaping (LENS), a direct laser deposition method. The porosity within the LENS samples, as well as their subsequent heat treatment, was varied to determine the effects of microstructure and defects on fatigue life. The as-built and heat-treated LENS samples, together with wrought Ti-6Al-4V samples, underwent fatigue testing and microstructure and fractographic inspection. The collected microstructure/defect statistics were used for calibrating a microstructure-sensitive fatigue model.FindingsFatigue lives of the LENS Ti-6Al-4V samples were found to be consistently less than those of the wrought Ti-6Al-4V samples, and this is attributed to the presence of pores/defects within the LENS material. Results further indicate that LENS Ti-6Al-4V fatigue lives, as predicted by the used microstructure-sensitive fatigue model, are in close agreement with experimental results. The used model could predict upper and lower prediction bounds based on defect statistics. All the fatigue data were found to be within the bounds predicted by the microstructure-sensitive fatigue model.Research limitations/implicationsTo further test the utility of microstructure-sensitive fatigue models for predicting fatigue life of AM samples, future studies on additional material types, additive manufacturing processes and heat treatments should be conducted.Originality/valueThis study shows the utility of a microstructure-sensitive fatigue model for use in predicting the fatigue life of LENS Ti-6Al-4V with various levels of porosity and while in a heat-treated condition.
Development, printability and post-curing studies of formulations of materials resistant to microbial attachment for use in inkjet based 3D printing
Authors: Begines Belen , Hook Andrew L. , Alexander Morgan R. , Tuck Christopher J. , Wildman Ricky D. 
Published: September 2016

Purpose
This paper aims to print 3D structures from polymers that resist bacterial attachment by reactive jetting of acrylate monomers.

Design/methodology/approach
The first step towards printing was ink development. Inks were characterised to carry out an estimation of their potential printability using the Z parameter to predict stable jetting conditions. Printability conditions were optimised for each ink using a Dimatix DMP-2800, which enabled 3D structures to be fabricated.

Findings
UV photo-initiated polymers, which resist bacterial attachment, were found to be printable using piezo-based inkjet printers. The waveform required for each ink depends on the value of the Z parameter. Once the waveform and the printability parameters were optimised, 3D objects were fabricated.

Research limitations/implications
This methodology has been confirmed as an effective method to 3D print materials that have been demonstrated to be bacteria resistant. However, ink curing depends on modification of some parameters (such as photoinitiator concentration or UV exposure time) which would result in an improvement of the curing process post jetting.

Social implications
The combination of inkjet based 3D printing with new materials resistant to bacterial attachment means the possibility of building customised medical devices with a high level of complexity and bespoke features can be fully realised. The scope and variability of the devices produced will exceed what can be achieved using standard fabrication methodologies and can be applied to reduce the incidence of device associated infections and to address increased morbidity, mortality and health care costs associated with nosocomial infections.

Originality/value
In this paper, the novel use of materials that resist bacterial attachment has been described to build 3D structures using material jetting. Its value lies on the potential impact this methodology could produce in the biomedical device and research fields.
Rethinking microaggressions and anti-social behaviour against LGBTIQ+ youth
Authors: Roffee James A. , Waling Andrea 
Published: September 2016

Purpose
The purpose of this paper is to further the understanding of experiences of anti-social behaviour in LGBTIQ+ youth in university settings.

Design/methodology/approach
The discussion reflects on qualitative interviews with LGBTIQ+ young people studying at university (n=16) exploring their experiences of anti-social behaviour including harassment, bullying and victimisation in tertiary settings.

Findings
The findings demonstrate that attention should be paid to the complex nature of anti-social behaviour. In particular, LGBTIQ+ youth documented experiences of microaggressions perpetrated by other members of the LGBTIQ+ community. Using the taxonomy of anti-social behaviour against LGBTIQ+ people developed by Nadal et al. (2010, 2011), the authors build on literature that understands microaggressions against LGBTIQ+ people as a result of heterosexism, to address previously unexplored microaggressions perpetrated by other LGBTIQ+ people.

Research limitations/implications
Future research could seek a larger sample of participants from a range of universities, as campus climate may influence the experiences and microaggressions perpetrated.

Practical implications
Individuals within the LGBTIQ+ community also perpetrate microaggressions against LGBTIQ+ people, including individuals with the same sexual orientation and gender identity as the victim. Those seeking to respond to microaggressions need to attune their attention to this source of anti-social behaviour.

Originality/value
Previous research has focused on microaggressions and hate crimes perpetrated by non-LGBTIQ+ individuals. This research indicates the existence of microaggressions perpetrated by LGBTIQ+ community members against other LGBTIQ+ persons. The theoretical taxonomy of sexual orientation and transgender microaggressions is expanded to address LGBTIQ+ perpetrated anti-social behaviour.