bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the Visible‐Light Response of CeO2−x with a high Ce3+ Content and Its Photocatalytic Properties
Authors: Yuán Sàisài , Xu Bin , Zhang Qitao , Liu Sixiao , Xie Ju , Zhang Ming , Ohno Teruhisa 
Published: December 2017

AbstractPhotocatalysts that are responsive to visible light are necessary to utilize solar energy. We prepared reduced CeO2−x with absorption in the visible region by a simple solvothermal method. A new absorption band appearing at λ≈500 nm (surface plasmon resonance) could be ascribed to the high content of Ce3+. To elucidate the relationship between Ce3+ and activity, the decomposition of isopropyl alcohol (IPA) to generate acetone was performed under visible‐light irradiation. CeO2−x showed activity that was superior to that of pure CeO2. Ce3+ induced oxygen vacancies in the lattice of CeO2−x, and this resulted in an improvement in the activity. In addition, the introduction of Ce3+ resulted in an improvement in the absorption of CeO2−x in the visible‐light region. Also, the appearance of small tentacles (Confeito‐like) on the surface of CeO2−x not only provided more active sites but also prevented aggregation. Owing to its visible‐light responsiveness and unique morphology, the performance of this material was significantly improved relative to that of pure CeO2.
A Precisely Assembled Carbon Source to Synthesize Fluorescent Carbon Quantum Dots for Sensing Probes and Bioimaging Agents
Authors: Qiao Yiqiang , Luo Dan , Yu Min , Zhang Ting , Cao Xuanping , Zhou Yanheng , Liu Yan 
Published: December 2017

AbstractA broad range of carbon sources have been used to fabricate varieties of carbon quantum dots (CQDs). However, the majority of these studies concern the influence of primary structures and chemical compositions of precursors on the CQDs; it is still unclear whether or not the superstructures of carbon sources have effects on the physiochemical properties of the synthetic CQDs. In this work, the concept of molecular assembly is first introduced into the design of a new carbon source. Compared with the tropocollagen molecules, the hierarchically assembled collagen scaffolds, as a new carbon source, immobilize functional groups of the precursors through hydrogen bonds, electrostatic attraction, and hydrophobic forces. Moreover, the accumulation of functional groups in collagen self‐assembly further promotes the covalent bond formation in the obtained CQDs through a hydrothermal process. Both of these two chemical superiorities give rise to high quality CQDs with enhanced emission. The assembled collagen scaffold‐based CQDs with heteroatom doping exhibit superior stability, and could be further applied as effective fluorescent probes for Fe3+ detection and cellular cytosol imaging. These findings open a wealth of possibilities to explore more nanocarbons from precursors with assembled superstructures.
Potent Inhibitors against Newcastle Disease Virus Hemagglutinin‐Neuraminidase
Authors: Rota Paola , La Rocca Paolo , Piccoli Marco , Montefiori Marco , Cirillo Federica , Olsen Lars , Orioli Marica , Allevi Pietro , Anastasia Luigi 
Published: December 2017

AbstractNeuraminidase activity is essential for the infection and propagation of paramyxoviruses, including human parainfluenza viruses (hPIVs) and the Newcastle disease virus (NDV). Thus, many inhibitors have been developed based on the 2‐deoxy‐2,3‐didehydro‐d‐N‐acetylneuraminic acid inhibitor (DANA) backbone. Along this line, herein we report a series of neuraminidase inhibitors, having C4 (p‐toluenesulfonamido and azido substituents) and C5 (N‐perfluorinated chains) modifications to the DANA backbone, resulting in compounds with 5‐ to 15‐fold greater potency than the currently most active compound, the N‐trifluoroacetyl derivative of DANA (FANA), toward the NDV hemagglutinin‐neuraminidase (NDV‐HN). Remarkably, these inhibitors were found to be essentially inactive against the human sialidase NEU3, which is present on the outer layer of the cell membrane and is highly affected by the current NDV inhibitor FANA.
Body composition in long‐term survivors of acute lymphoblastic leukemia diagnosed in childhood and adolescence: A focus on sarcopenic obesity
Authors: Marriott Christopher J. C. , Beaumont Lesley F. , Farncombe Troy H. , Cranston Amy N. , Athale Uma H. , Yakemchuk Valerie N. , Webber Colin E. , Barr Ronald D. 
Published: December 2017

BACKGROUNDThe late effects of treatment for acute lymphoblastic leukemia (ALL) include disordered body composition, especially obesity. Less attention has been focused on the loss of skeletal muscle mass (SMM) and the combined morbidity of sarcopenic obesity.METHODSA cross‐sectional study of body composition was undertaken via dual‐energy x‐ray absorptiometry in 75 long‐term survivors of ALL (more than 10 years after the diagnosis). Measures were obtained of the fat mass (FM), fat‐free mass (equivalent to the lean body mass [LBM]), and whole‐body bone mineral content. Health‐related quality of life (HRQL) was measured with the Health Utilities Index.RESULTSThe sum of the FM, LBM, and whole‐body bone mineral content matched the total body weight measured directly (r = 0.998). The appendicular lean mass (ALM) was derived from the LBM in all 4 limbs and accounted for approximately 75% of the SMM. According to the fat mass index (FMI; ie, FM/height2), 12% of females and 18% of males were frankly obese by World Health Organization criteria. The median FMI z score was + 0.40, whereas the median z score for the appendicular lean mass index (ALMI; ie, ALM/height2) was –0.40. Sarcopenic obesity, defined as a positive FMI z score with a negative ALMI z score, was present in 32 subjects (43%). There were statistically significant and clinically important differences in overall HRQL between subjects with and without sarcopenic obesity.CONCLUSIONSSarcopenic obesity is prevalent in long‐term survivors of ALL, and this places them in double jeopardy from excess body fat and inadequate SMM (eg, a combination of metabolic and frailty syndromes). It is associated with an adverse impact on overall HRQL. Cancer 2018;124:1225‐31. © 2017 American Cancer Society.
A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and gray mouse lemur (Microcebus murinus)
Authors: Pellegrino Giuliana , Trubert Claire , Terrien Jérémy , Pifferi Fabien , Leroy Danièle , Loyens Anne , Migaud Martine , Baroncini Marc , Maurage Claude‐Alain , Fontaine Christian , Prévot Vincent , Sharif Ariane 
Published: December 2017

AbstractThe adult brain contains niches of neural stem cells that continuously add new neurons to selected circuits throughout life. Two niches have been extensively studied in various mammalian species including humans, the subventricular zone of the lateral ventricles and the subgranular zone of the hippocampal dentate gyrus. Recently, studies conducted mainly in rodents have identified a third neurogenic niche in the adult hypothalamus. In order to evaluate whether a neural stem cell niche also exists in the adult hypothalamus in humans, we performed multiple immunofluorescence labeling to assess the expression of a panel of neural stem/progenitor cell (NPC) markers (Sox2, nestin, vimentin, GLAST, GFAP) in the human hypothalamus and compared them with the mouse, rat and a non‐human primate species, the gray mouse lemur (Microcebus murinus). Our results show that the adult human hypothalamus contains four distinct populations of cells that express the five NPC markers: (a) a ribbon of small stellate cells that lines the third ventricular wall behind a hypocellular gap, similar to that found along the lateral ventricles, (b) ependymal cells, (c) tanycytes, which line the floor of the third ventricle in the tuberal region, and (d) a population of small stellate cells in the suprachiasmatic nucleus. In the mouse, rat and mouse lemur hypothalamus, co‐expression of NPC markers is primarily restricted to tanycytes, and these species lack a ventricular ribbon. Our work thus identifies four cell populations with the antigenic profile of NPCs in the adult human hypothalamus, of which three appear specific to humans.
Modified pyramid dual tree direction filter‐based image denoising via curvature scale and nonlocal mean multigrade remnant filter
Authors: Teng Lin , Li Hang , Yin Shoulin 
Published: December 2017

SummaryTo alleviate the disadvantage of traditional image denoising method in big images data, we propose a modified pyramid dual tree direction filter with nonlocal mean multigrade remnant filter for image denoising in this paper. The proposed denoising method is partitioned into 4 processes. Firstly, curvature scale model is used for building pyramid dual tree direction filter coefficients of noised image. Additionally, the coefficients are calculated by robust Bayes least square method. Then, we use pyramid dual tree direction filter inverse transformation to reconstruct an initial denoised image. At last, nonlocal mean multigrade remnant filter is adopted to filter the initial denoised image and we obtain the final denoised image. The proposed method completely used the multiscale and multidirectional selectivity with approximately translation invariance of pyramid dual tree direction filter. Finally, we assess the image denoising performance of the proposed approach over several test images and compare our results with the state‐of‐the‐art denoising algorithms. Our experiments show that the proposed image denoising method achieves better results than other methods. Furthermore, our new method not only effectively removes the noise but also better keeps the edge and detail information of texture and structure.
Organic Structure‐Directing Agents in SAPO Synthesis: The Case of 2‐Ethyl‐1,3,4‐trimethylimidazolium
Authors: Vinaches Paloma , Pergher Sibele B. C. 
Published: December 2017

AbstractInvited for the cover of this issue is the group of SibeleàB.àC. Pergher from Federal University of Rio Grande do Norte, Natal, Brazil. The cover image shows that the SAPO materials were not obtained by a magic trick but by use of the organic molecule 2‐ethyl‐1,3,4‐trimethylimidazolium, directing to two different structures, the LTA and CHA zeotypes.
A Novel Blue to Transparent Polymer for Electrochromic Supercapacitor Electrodes
Authors: Yuksel R. , Ekber A. , Turan J. , Alpugan E. , Hacioglu S. O. , Toppare L. , Cirpan A. , Gunbas G. , Unalan H. E. 
Published: December 2017

AbstractElectrochromic supercapacitors may alert the user on the remaining capacity of the devices. The color change indicating the remaining capacity can be simply and rapidly recognized by the human eye or by optical instruments. A rapid indication of charged state may extend device service life and prevent overcharging, which would otherwise result in electrode aging and decomposition. In this study, a blue to the transmissive electrochromic polymer, poly(4,7‐bis(2,3‐dihydrothieno[3, 4‐B][1, 4]dioxin‐5‐YI)‐2‐(2‐octyldodecyl)‐2H‐benzo[D][1, 2,3]triazole) (P1C), was used in nanocomposite form with transparent silver nanowire (Ag NW) network current collectors for the fabrication of electrochromic supercapacitor electrodes. Highly conductive and transparent Ag NW networks have an important role in the realization of electrochromic supercapacitors using P1C. Fabricated Ag NW/P1C nanocomposite electrodes had a specific capacitance of 65.0 F g−1 at a current density of 0.1 A g−1. Nanocomposite electrode showed excellent stability (capacity retention of>98 %) after 11000 cycles associated with a resistance decrease associated with charge transfer.
Application of RNA Aptamers as Recognition Layers for the Electrochemical Analysis of C‐Reactive Protein
Authors: Jarczewska Marta , Ziółkowski Robert , Górski Łukasz , Malinowska Elżbieta 
Published: December 2017

AbstractC‐reactive protein (CRP) is one of the crucial biomarkers of inflammation, as well as cardiovascular and cancer diseases. Hence, the development of a sensitive and selective technique for CRP detection is of special importance. One of the possibilities is the application of biosensors containing receptor elements formed of RNA aptamers, as they exhibit high affinity towards C‐reactive protein. Herein, the capability of utilization of thiolated RNA aptamers as sensing layers was verified. The occurrence of aptamer ‐ C‐reactive protein interaction was confirmed by quartz crystal microbalance experiments. The voltammetric measurements performed in the presence of methylene blue redox indicator showed a linear current decrease within 1–100 pmol L−1 range of protein concentration. The interaction between surface‐tethered aptamer and CRP was distinguished with dissociation constant of 25.9 pmol L−1. The developed assay demonstrated a pronounced selectivity to CRP over interfering proteins as well as capability of CRP analysis in serum sample.
Electrical Characteristics of a Hybrid Photovoltaic/Thermoelectric Generator System
Authors: Pang Wei , Yu Hongwen , Zhang Yongzhe , Yan Hui 
Published: December 2017

AbstractThe electrical performance evolution of a system combining photovoltaic (PV) and thermoelectric generator (TE) is evaluated using thermal resistance calculations. The hybrid system combines a commercial monocrystalline silicon PV and a commercial bismuth telluride TE that is integrated with heat sinks. Here, photovoltaic modules could be cooled using thermoelectric components, leading to an increase in its output power. Additionally, extra thermal electricity is generated from the temperature difference between the backside of photovoltaic modules and heat sinks. Compared with the PV, the photovoltaic conversion efficiency of the PV/TE integrated system is increased by 3.9 % and the total system efficiency is up to 5.9 %.
A multicatchment analysis of headwater and downstream temperature effects from contemporary forest harvesting
Authors: Bladon Kevin D. , Segura Catalina , Cook Nicholas A. , Bywater‐Reyes Sharon , Reiter Maryanne 
Published: December 2017

AbstractStream temperature is a key physical water‐quality parameter, controlling many biological, chemical, and physical processes in aquatic ecosystems. Maintenance of cool stream temperatures during summer is critical for high‐quality aquatic habitat. As such, transmission of warm water from small, nonfish‐bearing headwater streams after forest harvesting could cause warming in downstream fish‐bearing stream reaches with negative consequences. In this study, we evaluate (a) the effects of contemporary forest management practices on stream temperature in small, headwater streams, (b) the transmission of thermal signals from headwater reaches after harvesting to downstream fish‐bearing reaches, and (c) the relative role of lithology and forest management practices in influencing differential thermal responses in both the headwater and downstream reaches. We measured summer stream temperatures both preharvest and postharvest at 29 sites—12 upstream sites (4 reference, 8 harvested) and 17 downstream sites (5 reference, 12 harvested)—across 3 paired watershed studies in western Oregon. The 7‐day moving average of daily maximum stream temperature (T7DAYMAX) was greater during the postharvest period relative to the preharvest period at 7 of the 8 harvested upstream sites. Although theT7DAYMAXwas generally warmer in the downstream direction at most of the stream reaches during both the preharvest and postharvest period, there was no evidence for additional downstream warming related to the harvesting activity. Rather, theT7DAYMAXcooled rapidly as stream water flowed into forested reaches ~370–1,420 m downstream of harvested areas. Finally, the magnitude of effects of contemporary forest management practices on stream temperature increased with the proportion of catchment underlain by more resistant lithology at both the headwater and downstream sites, reducing the potential for the cooling influence of groundwater.
Mediating stream baseflow response to climate change: The role of basin storage
Authors: Buttle James M. 
Published: December 2017

AbstractInter‐basin differences in streamflow response to changes in regional hydroclimatology may reflect variations in storage characteristics that control the retention and release of water inputs. These aspects of storage could mediate a basin's sensitivity to climate change. The hypothesis that temporal trends in stream baseflow exhibit a more muted reaction to changes in precipitation and evapotranspiration for basins with greater storage was tested on the Oak Ridges Moraine (ORM) in Southern Ontario, Canada. Long‐term (>25 years) baseflow trends for 16 basins were compared to corresponding trends in precipitation amount and type and in potential evapotranspiration as well as shorter trends in groundwater levels for monitoring wells on the ORM. Inter‐basin differences in storage properties were characterized using physiographic, hydrogeologic, land use/land cover, and streamflow metrics. The latter included the slope of the basin's flow duration curve and basin dynamic storage. Most basins showed temporal increases in baseflow, consistent with limited evidence of increases and decreases in regional precipitation and snowfall: precipitation ratio, respectively, and recent increases in groundwater recharge along the crest of the ORM. Baseflow trend magnitude was uncorrelated to basin physiographic, hydrogeologic, land use/land cover, or flow duration curve characteristics. However, it was positively related to a basin's dynamic storage, particularly for basins with limited coverage of open water and wetlands. The dynamic storage approach assumes that a basin behaves as a first‐order dynamical system, and extensive open water and wetland areas in a basin may invalidate this assumption. Previous work suggested that smaller dynamic storage was linked to greater damping of temporal variations in water inputs and reduced interannual variability in streamflow regime. Storage and release of water inputs to a basin may assist in mediating baseflow response to temporal changes in regional hydroclimatology and may partly account for inter‐basin differences in that response. Such storage characteristics should be considered when forecasting the impacts of climate change on regional streamflow.
Retracted: LncRNA AWPPH inhibits SMAD4 via EZH2 to regulate bladder cancer progression
Authors: Zhu Feng , Zhang Xinjun , Yu Qinnan , Han Guangye , Diao Fengxia , Wu Chunlei , Zhang Yan 
Published: December 2017

AbstractThis study aimed to investigate the effect and underlying mechanism of lncRNA AWPPH in bladder cancer (BC). A total of 20 Ta‐T1 stage BC tissues, 20 T2‐T4 stage BC tissues, and 20 normal bladder tissues, as well as human bladder epithelial cell line SV‐HUC‐1, human BC cell lines RT4, and T24 were obtained to detect the levels of AWPPH, enhancer of zeste homolog 2 (EZH2) and SMAD4 using RT‐qPCR or Western blotting. RT4 cells were transfected with pc‐AWPPH, pc‐EZH2, or pc‐control and T24 cells were transfected with si‐AWPPH, si‐EZH2, si‐control, or pc‐AWPPH + pc‐SMAD4, respectively. Then, cell proliferation, apoptosis, autophagy, and migration, were detected using MTT assay, colony formation assay, Annexin V‐FITC/PI method, Western blotting, and Transwell analysis, respectively. The relationship of AWPPH and EZH2 or SMAD4 was evaluated by RNA immunoprecipitation (RIP) assay or Chromatin immunoprecipitation (ChIP) assay. Compared with normal bladder tissues or cells, the levels of AWPPH and EZH2 were overexpressed, while SMAD4 was down‐regulated in BC tissues or cells (all P < 0.01). Cell viability, colony number, and migration were significantly increased, while cell apoptosis ratio was reduced in cells with pc‐AWPPH compared with cells with pc‐control (all P < 0.05), meanwhile, these effects were reversed by the treatment of pc‐SMAD4. Then, RIP assay revealed that AWPPH could bind to EZH2 and ChIP assay showed SMAD4 was regulated by EZH2. LncRNA AWPPH can promote cell proliferation, autophagy, and migration, as well as inhibit cell apoptosis in BC by inhibiting SMAD4 via EZH2.
The structural and functional reliability of Circulins of Chassalia parvifolia for peptide therapeutic scaffolding
Authors: Balaraman Senthilkumar , Ramalingam Rajasekaran 
Published: December 2017

AbstractComputational methods have refined the mode of peptide drug designing to a new plateau recently. Circulin, a 30 residue natural plant polypeptide acts as a plant defensive peptide. Additional to its antimicrobial activity it also possesses an inhibitory cytopathic effect on the replication of human immunodeficiency virus (HIV). Stable Circulin can be a functionally able template for scaffolding peptide based drugs. Hence, structural stability of Chassalia parvifolia, Circulin A (1BH4), and Circulin B (2ERI) was computationally investigated. From this analysis, the stability favored toward Circulin B which was supported by various parameters such as intra‐molecular interactions (61), secondary structure, hydrophobicity (67.34%), root mean square deviation (2.64Å), root mean square fluctuation (0.08Å), radius of gyration (8.96Å), ovality (3.49), angular deviation (73.6%), surface area (both polar and non‐polar), hydrogen bond distribution (11.94), and disulphide bond distances. Further, the functional activity calculated in terms of membrane associated free energy (−4.10 kcal/mol) also favored Circulin B. Hence, Circulin B could be proposed as the best template for scaffolding antimicrobial as well as antiviral (HIV) peptide based drug design. The obtained computational data can aid experimental biologists to successfully produce stable therapeutic peptides from natural resources reducing erroneous wastage of monetary sources and time.
Halofuginone‐induced autophagy suppresses the migration and invasion of MCF‐7 cells via regulation of STMN1 and p53
Authors: Xia Xiaojing , Wang Lei , Zhang Xiaojian , Wang Shan , Lei Lianchen , Cheng Likun , Xu Yanzhao , Sun Yawei , Hang Bolin , Zhang Gaiping , Bai YueYu , Hu JianHe 
Published: December 2017

AbstractTraditional Chinese medicines have been recognized as especially promising anticancer agents in modern anticancer research. Halofuginone (HF), an analog of quinazolinone alkaloid extracted from Dichroa febrifuga, is widely used in traditional medicine. However, whether HF inhibits the growth of breast cancer cells and/or reduces the migration and invasion of MCF‐7 human breast cancer cells, as well as the underlying mechanisms in vitro, remains unclear. In this study, we report that an HF extract inhibits the growth of MCF‐7 cells and reduces their migration and invasion, an important feature of potential anticancer agents. In addition, HF significantly increases the activation of autophagy, which is closely associated with tumor metastasis. As STMN1 and p53 have been closely implicated in breast cancer progression, we analyzed their expression in the context of HF extract treatment. Western blot analysis showed that HF suppresses STMN1 and p53 expression and activity in an autophagy‐dependent manner. Collectively, these data indicate that activation of autophagy reduces expression of STMN1 and p53, and the migration and invasion of cancer cells contributes to the anti‐cancer effects of the HF. These findings may provide new insight into breast cancer prevention and therapy.