bluuebunny/crossref_metadata_2025_split huggingface dataset:
The technostress trifecta ‐ techno eustress, techno distress and design: Theoretical directions and an agenda for research
Authors: Tarafdar Monideepa , Cooper Cary L. , Stich Jean‐François 
Published: November 2017

AbstractTechnostress—defined as stress that individuals experience due to their use of Information Systems—represents an emerging phenomenon of scholarly investigation. It examines how and why the use of IS causes individuals to experience various demands that they find stressful. This paper develops a framework for guiding future research in technostress experienced by individuals in organizations. We first review and critically analyse the state of current research on technostress reported in journals from the IS discipline and the non‐IS disciplines that study stress in organizations (eg, organizational behaviour and psychological stress). We then develop our framework in the form of the “technostress trifecta”—techno‐eustress, techno‐distress, and Information Systems design principles for technostress. The paper challenges 3 key ideas imbued in the existing technostress literature. First, it develops the argument that, in contrast to negative outcomes, technostress can lead topositive outcomes such as greater effectiveness and innovationat work. Second, it suggests that instead of limiting the role of IS to that of being a stress creator in the technostress phenomenon, it should beexpanded to that of enhancing the positive and mitigating the negative effects of technostressthrough appropriate design. Third, it lays the groundwork for guiding future research in technostress through aninterdisciplinary framing that enriches both the IS and the psychological stress literaturesthrough a potential discourse of disciplinary exchange.
Molecular testing of adult Pacific salmon and trout (Oncorhynchus spp.) for several RNA viruses demonstrates widespread distribution of piscine orthoreovirus in Alaska and Washington
Authors: Purcell M K , Powers R L , Evered J , Kerwin J , Meyers T R , Stewart B , Winton J R 
Published: November 2017

AbstractThis research was initiated in conjunction with a systematic, multiagency surveillance effort in the United States (U.S.) in response to reported findings of infectious salmon anaemia virus (ISAV) RNA in British Columbia, Canada. In the systematic surveillance study reported in a companion paper, tissues from various salmonids taken from Washington and Alaska were surveyed for ISAV RNA using the U.S.‐approved diagnostic method, and samples were released for use in this present study only after testing negative. Here, we tested a subset of these samples for ISAV RNA with three additional published molecular assays, as well as for RNA from salmonid alphavirus (SAV), piscine myocarditis virus (PMCV) and piscine orthoreovirus (PRV). All samples (n = 2,252; 121 stock cohorts) tested negative for RNA from ISAV, PMCV, and SAV. In contrast, there were 25 stock cohorts from Washington and Alaska that had one or more individuals test positive for PRV RNA; prevalence within stocks varied and ranged from 2% to 73%. The overall prevalence of PRV RNA‐positive individuals across the study was 3.4% (77 of 2,252 fish tested). Findings of PRV RNA were most common in coho (Oncorhynchus kisutch Walbaum) and Chinook (O. tshawytscha Walbaum) salmon.
Cognitive Outcomes After Transcatheter Aortic Valve Implantation: A Metaanalysis
Authors: Khan Maisha M. , Herrmann Nathan , Gallagher Damien , Gandell Dov , Fremes Stephen E. , Wijeysundera Harindra C. , Radhakrishnan Sam , Sun Yue Ran , Lanctôt Krista L. 
Published: November 2017

ObjectivesTo quantitatively summarize changes in cognitive performance in individuals with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).DesignMetaanalysis.ParticipantsIndividuals undergoing TAVI (N = 1,065 (48.5% male) from 18 studies, average age ≥80).MeasurementsThe MEDLINE, EMBASE, and Cochrane Central databases were searched for original peer‐reviewed reports assessing cognitive performance using standardized cognitive tests before and after TAVI. Data were extracted for cognitive scores before TAVI; perioperatively (within 7 days after TAVI); 1, 3, and 6 months after TAVI, and 12 to 34 months after TAVI (over the long term). Standardized mean differences (SMDs) were generated using random‐effects models for changes in cognition at each time point. Metaregression analyses were conducted to assess the association between population and procedural characteristics and cognitive outcomes. Risk of bias was assessed.ResultsThere were no significant changes from baseline in perioperative cognitive performance (SMD = 0.05, 95% confidence interval (CI) = −0.08–0.18; z = 0.75, P = .46), although overall cognitive performance had improved significantly 1 month after TAVI (SMD = −0.33, 95% CI = −0.50 to −0.16; z = 3.83, P < .001). There were no differences in cognitive performance 3 and 6 months after TAVI or over the long term. Cognitive outcomes were not associated with any covariates in regression analyses.ConclusionCognitive performance is preserved after TAVI, suggesting TAVI is not detrimental to cognition.
The ability to self‐monitor cognitive performance during 60 h total sleep deprivation and following 2 nights recovery sleep
Authors: Boardman Johanna M. , Bei Bei , Mellor Alix , Anderson Clare , Sletten Tracey L. , Drummond Sean P. A. 
Published: November 2017

SummaryWe aimed to investigate whether self‐monitoring of performance is altered during 60 h of total sleep deprivation, following 2 nights of recovery sleep, and by task difficulty and/or subjective sleepiness. Forty adults (22 females, aged 19–39 years) underwent a 5‐day protocol, with a well‐rested day, 66 h total sleep deprivation (last test session at 60 h), and 2 nights of 8 h recovery sleep. An arithmetic task (MATH) with three difficulty levels assessed working memory. The Psychomotor Vigilance Task assessed sustained attention. Arithmetic accuracy and Psychomotor Vigilance Task median reaction time measured objective performance. Subjective performance was measured with self‐reported accuracy and speed. Objective–subjective differences assessed self‐monitoring ability. The performance on both tasks declined during total sleep deprivation and improved following recovery. During total sleep deprivation, participants accurately self‐monitored performance on the Psychomotor Vigilance Task; however, they overestimated cognitive deficits on MATH, self‐reporting performance as worse than actually observed. Following recovery, participants overestimated the extent of performance improvement on the Psychomotor Vigilance Task. Task difficulty influenced self‐monitoring ability, with greater overestimation of performance deficits during total sleep deprivation as difficulty increased. Subjective sleepiness predicted subjective performance ratings at several time points, only for the Psychomotor Vigilance Task. The ability to self‐monitor performance was impaired during total sleep deprivation for working memory and after recovery sleep for the Psychomotor Vigilance Task, but was otherwise accurate. The development of self‐monitoring strategies, assessing both subjective perceptions of performance and subjective sleepiness, within operational contexts may help reduce the consequences of sleep‐related impairments.
Mapping the Role of Women in Indian Agriculture
Authors: MAJUMDER JOYDEEP , SHAH PRIYANKA 
Published: November 2017

AbstractWomen provide crucial support in Indian agriculture and household livelihood; however, they remain confined as workers. Designed farm tools available are mainly used by male farmers, and rural women are left to use traditional tools and procedures resulting in low efficiency, drudgery, occupational health risks, and low income. Their contributions fall under indirect material income and go unacknowledged even in decision making. Illiteracy, lack of knowledge among rural women, improper training, and less opportunity for skill development worsen their subdued existence. Formal education, availability of economically viable agricultural machinery for women, training, extension services, social engineering, and gender budgeting is need of the hour. Gender budgeting would assess the quantity and adequacy of allocation of resources for women and establish the extent to which gender commitments are translated into budgetary commitments. Active participation of rural women would boost their socioeconomic recognition, confidence in economic competence, and promulgate sustainable societal growth.
Functional differences in transport properties of natural HKT1;1 variants influence shoot Na+ exclusion in grapevine rootstocks
Authors: Henderson Sam W. , Dunlevy Jake D. , Wu Yue , Blackmore Deidre H. , Walker Rob R. , Edwards Everard J. , Gilliham Matthew , Walker Amanda R. 
Published: November 2017

Summary

Under salinity, Vitis spp. rootstocks can mediate salt (NaCl) exclusion from grafted V. vinifera scions enabling higher grapevine yields and production of superior wines with lower salt content. Until now, the genetic and mechanistic elements controlling sodium (Na+) exclusion in grapevine were unknown.

Using a cross between two Vitis interspecific hybrid rootstocks, we mapped a dominant quantitative trait locus (QTL) associated with leaf Na+ exclusion (NaE) under salinity stress. The NaE locus encodes six high‐affinity potassium transporters (HKT). Transcript profiling and functional characterization in heterologous systems identified VisHKT1;1 as the best candidate gene for controlling leaf Na+ exclusion.

We characterized four proteins encoded by unique VisHKT1;1 alleles from the parents, and revealed that the dominant HKT variants exhibit greater Na+ conductance with less rectification than the recessive variants. Mutagenesis of VisHKT1;1 and TaHKT1.5‐D from bread wheat, demonstrated that charged amino acid residues in the eighth predicted transmembrane domain of HKT proteins reduces inward Na+ conductance, and causes inward rectification of Na+ transport.

The origin of the recessive VisHKT1;1 alleles was traced to V. champinii and V. rupestris. We propose that the genetic and functional data presented here will assist with breeding Na+‐tolerant grapevine rootstocks.
Bleomycin‐induced flagellate erythema after venous malformation sclerosis—Case report and brief review
Authors: Pinto Cristina , Lorca‐Garcia Concepción , Berenguer Beatriz , De Tomás Palacios Maria Elena 
Published: November 2017

AbstractBleomycin‐induced flagellate erythema is a rare but typical skin toxicity of bleomycin. We report the case of a boy with a left foot venous malformation who developed this skin rash after two sessions of bleomycin intralesional injection. We discuss the mechanism and characteristics of this reaction to bleomycin, which is usually benign and self‐limited. We conclude that, although rare, flagellate pigmentation can occur when bleomycin is used as a sclerosant in children.
Severe Stevens‐Johnson syndrome/toxic epidermal necrolysis overlap syndrome—beyond skin involvement
Authors: Milheiro Silva Tiago , Farela Neves João , Casimiro Ana , Varandas Luís , Gouveia Catarina 
Published: November 2017

AbstractStevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but serious dermatologic diseases with many potential multisystem complications. We describe the case of an 8‐year‐old girl who developed severe SJS/TEN overlap syndrome (25% of her body surface area was affected) complicated by pancreatitis and bronchiolitis obliterans. These rare complications emphasize the need for careful, intensive monitoring of possible complications and an interdisciplinary team approach to provide optimal treatment and follow‐up.
Breathing space: the inspired ecosystem of Paradise Lost
Authors: Taylor Whitney B. 
Published: November 2017

AbstractThis essay argues that John Milton's Paradise Lost devises its poetic inspiration out of the combined theological and environmental concepts of a broader inspired creation as a space that breathes. Milton activates his vision of inspiration beyond the epic's proems to realize a more general shared breathing among humans, the divine, other creatures, and their environment. Many scholarly considerations of Milton's invocations have focused on poetic authority in the epic or anxieties that Milton's muse will usurp his voice. Reading an inspired ecosystem in Paradise Lost significantly recasts these questions in light of a much more pressing and immediate need for inspiration: the possibility that an inspired epic can offer the poet and his readers access to divine creation in the salvific form of poetry.
Xyloglucan in the primary cell wall: assessment by FESEM, selective enzyme digestions and nanogold affinity tags
Authors: Zheng Yunzhen , Wang Xuan , Chen Yuning , Wagner Edward , Cosgrove Daniel J. 
Published: November 2017

SummaryXyloglucan has been hypothesized to bind extensively to cellulose microfibril surfaces and to tether microfibrils into a load‐bearing network, thereby playing a central role in wall mechanics and growth, but this view is challenged by newer results. Here we combined high‐resolution imaging by field emission scanning electron microscopy (FESEM) with nanogold affinity tags and selective endoglucanase treatments to assess the spatial location and conformation of xyloglucan in onion cell walls. FESEM imaging of xyloglucanase‐digested cell walls revealed an altered microfibril organization but did not yield clear evidence of xyloglucan conformations. Backscattered electron detection provided excellent detection of nanogold affinity tags in the context of wall fibrillar organization. Labelling with xyloglucan‐specific CBM76 conjugated with nanogold showed that xyloglucans were associated with fibril surfaces in both extended and coiled conformations, but tethered configurations were not observed. Labelling with nanogold‐conjugated CBM3, which binds the hydrophobic surface of crystalline cellulose, was infrequent until the wall was predigested with xyloglucanase, whereupon microfibril labelling was extensive. When tamarind xyloglucan was allowed to bind to xyloglucan‐depleted onion walls, CBM76 labelling gave positive evidence for xyloglucans in both extended and coiled conformations, yet xyloglucan chains were not directly visible by FESEM. These results indicate that an appreciable, but still small, surface of cellulose microfibrils in the onion wall is tightly bound with extended xyloglucan chains and that some of the xyloglucan has a coiled conformation.
Living with Crohn’s disease: an exploratory cross-sectional qualitative study into decision-making and expectations in relation to autologous haematopoietic stem cell treatment (the DECIDES study)
Authors: Cooper Joanne , Blake Iszara , Lindsay James O , Hawkey Christopher J 
Published: November 2017

Background/ObjectivesSevere Crohn’s disease impacts negatively on individual quality of life, with treatment options limited once conventional therapies have been exhausted. The aim of this study was to explore factors influencing decision-making and expectations of people considering or participating in the Autologous Haematopoietic Stem Cell Treatment trial.MethodsAn international, cross-sectional qualitative study, involving semistructured face to face interviews across five sites (four UK and one Spain). 38 participants were interviewed (13 men, 25 women; age range 23–67 years; mean age 37 years). The mean age at diagnosis was 20 years. Interviews were audio recorded and transcribed verbatim and transcripts were analysed using a framework approach.ResultsFour themes emerged from the analysis: (1) ‘making your mind up’—a determination to receive stem cell treatment despite potential risks; (2) communicating and understanding risks and benefits; (3) non-participation—your choice or mine? (4) recovery and reframing of personal expectations.ConclusionsDecision-making and expectations of people with severe Crohn’s disease in relation to autologous haematopoietic stem cell treatment is a complex process influenced by participants’ histories of battling with their condition, a frequent willingness to consider novel treatment options despite potential risks and, in some cases, a raised level of expectation about the benefits of trial participation. Discussions with patients who are considering novel treatments should take into account potential ‘therapeutic misestimation’, thereby enhancing shared decision-making, informed consent and the communication with those deemed non-eligible.ASTIC trial EudraCT Number2005-003337-40: results.
A new risk locus inCHCHD5for hypertension and obesity in a Chinese child population: a cohort study
Authors: Wu Lijun , Gao Liwang , Zhao Xiaoyuan , Zhang Meixian , Wu Jianxin , Mi Jie 
Published: November 2017

ObjectiveCoiled-coil-helix-coiled-coil-helix domain containing 5 (CHCHD5), a mitochondrial protein, is involved in the oxidative folding process in the mitochondrial intermembrane space. A previous study identified a hypertension-related single nucleotide polymorphism (SNP), rs3748024, inCHCHD5in adults, but there are no reports regarding the association betweenCHCHD5and obesity, which is a known risk factor for hypertension. The aim of the present study is to investigate the associations of the SNP rs3748024 with hypertension and obesity.DesignCohort study.SettingInstitute of Pediatrics in China.ParticipantsWe genotyped the SNP rs3748024 in the Beijing Child and Adolescent Metabolic Syndrome study. A total of 3503 children participated in the study.Primary and secondary outcome measuresGenotyping of rs3748024 was conducted using the TaqMan Allelic Discrimination Assay. Lipids and glucose were analysed by an automatic biochemical analyser using a kit assay. The levels of adipocytokines (leptin, adiponectin and resistin) were measured by ELISA techniques.ResultsThere was a statistically significant association between rs3748024 and systolic blood pressure (SBP) (β=−0.853, 95% CI −1.482 to −0.024, p=0.044) under an additive model adjusted for age, gender and body mass index (BMI) after correction for multiple testing. The SNP was also significantly associated with BMI (β=−0.286, 95% CI −0.551 to −0.021, p=0.043), obesity (OR=0.828, 95% CI 0.723 to 0.949, p=0.018) and triglycerides (β=−0.039, 95% CI −0.070 to −0.007, p=0.044) after correction for multiple testing.ConclusionsWe demonstrate for the first time that the SNP rs3748024 inCHCHD5is associated with SBP, BMI, obesity and triglycerides in Chinese children. Our study identifies a new risk locus for hypertension and obesity in a child population. The function of CHCHD5 remains to be further studied to help elucidate the pathogenic role of CHCHD5 in hypertension and obesity.
Cross-sectional comparative study of risky sexual behaviours among HIV-infected persons initiated and waiting to start antiretroviral therapy in rural Rakai, Uganda
Authors: Nakiganda Lydia Jacenta , Nakigozi Gertrude , Kagaayi Joseph , Nalugoda Fred , Serwadda David , Sewankambo Nelson , Gray Ronald , Ndyanabo Anthony , Muwanika Richard , Asamoah Benedict Oppong 
Published: November 2017

ObjectivesTo compare risky sexual behaviours between HIV-positive persons initiated on antiretroviral therapy (ART) (ART-experienced) and persons waiting to start on ART (ART-naive) and assess predictors of risky sexual behaviours among HIV-infected patients in rural Rakai district, Uganda.Study designThis is a cross-sectional study that used data from the Rakai Community Cohort Study (RCCS) database between 2013 and 2014. A structured questionnaire was used for data collection. We used stepwise logistic regression as an index to estimate the adjusted ORs for the association between risky sexual behaviours and ART treatment status.Study settingThis study was conducted in Rakai district, located in south-western Uganda. The data for this study were extracted from the RCCS. RCCS is an open prospective cohort of approximately 15 000 consenting participants aged 15–49 years.ParticipantsHIV-positive participants aged 18–49 years who had sex at least once a month with any partner prior to the start of the study.Main outcome measuresInconsistent/no condom use in the last 12 months, alcohol use at last sexual encounter, and two or more sexual partners.ResultsART-naive participants were more likely to report inconsistent condom use (OR=1.74, 95% CI 1.11 to 2.73) and more likely to drink alcohol at last sexual encounter (OR=1.65, 95% CI 1.11 to 2.46), compared with ART-experienced patients. ART treatment status (p<0.001) was a significant predictor of risky sexual behaviours. Both marital status (p=0.016) and occupation level (p=0.009) were positively associated with inconsistent condom use, while sex (p<0.001) correlated with alcohol use at last sexual encounter.ConclusionART-naive participants were more likely to exhibit risky sexual behaviours than the ART-experienced participants. The intensity of risk reduction counselling should be increased for HIV-positive persons waiting to start ART but already in HIV care.
Cost-effectiveness of planned birth in a birth centre compared with alternative planned places of birth: results of the Dutch Birth Centre study
Authors: Hitzert Marit , Hermus Marieke, MAA , Boesveld Inge, IC , Franx Arie , van der Pal-de Bruin Karin, KM , Steegers Eric, EAP , van den Akker-van Marle EIske, ME 
Published: November 2017

ObjectivesTo estimate the cost-effectiveness of a planned birth in a birth centre compared with alternative planned places of birth for low-risk women. In addition, a distinction has been made between different types of locations and integration profiles of birth centres.DesignEconomic evaluation based on a prospective cohort study.Setting21 Dutch birth centres, 46 hospital locations where midwife-led birth was possible and 110 midwifery practices where home birth was possible.Participants3455 low-risk women under the care of a community midwife at the start of labour in the Netherlands within the study period 1 July 2013 to 31 December 2013.Main outcome measuresCosts and health outcomes of birth for different planned places of birth. Healthcare costs were measured from start of labour until 7 days after birth. The health outcomes were assessed by the Optimality Index-NL2015 (OI) and a composite adverse outcomes score.ResultsThe total adjusted mean costs for births planned in a birth centre, in a hospital and at home under the care of a community midwife were €3327, €3330 and €2998, respectively. There was no difference between the score on the OI for women who planned to give birth in a birth centre and that of women who planned to give birth in a hospital. Women who planned to give birth at home had better outcomes on the OI (higher score on the OI).ConclusionsWe found no differences in costs and health outcomes for low-risk women under the care of a community midwife with a planned birth in a birth centre and in a hospital. For nulliparous and multiparous low-risk women, planned birth at home was the most cost-effective option compared with planned birth in a birth centre.