bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Tranexamic Acid in Total Knee Arthroplasty – Prospective Randomized Trial
Authors: Guerreiro Joao Paulo Fernandes , Badaro Bruno Scatolon , Balbino Jose Rodolfo Martines , Danieli Marcus Vinicius , Queiroz Alexandre Oliveira , Cataneo Daniele Cristina 
Published: September 2017

Background:The use of tranexamic acid (TXA) in total knee arthroplasty (TKA) has shown good results. Bleeding may cause local complications consequently greater pain and reduced function postoperatively. No study has related the use of TXA to these facts.Objective:The aim was to evaluate the effects of TXA haemoglobin, Western Ontario and McMaster Universities Index (WOMAC), pain intensity and flexion gain after TKA.Methods:43 patients were randomized and then underwent TKA. TXA was applied to 22 of these patients before closure of the joint capsule. Haemoglobin measurements (mg/dL) were taken preoperatively and 24 and 48 hours after surgery. The WOMAC questionnaire and pain visual analogue scale (VAS) were applied, and flexion gain was measured up to the second postoperative month. Statistical analysis compared the results to determine whether there were differences between the groups for each of the evaluated times.Results:There were differences in favour of the drug 48 hours postoperatively for the haemoglobin variable (p = 0.01), in pain evaluation, 24 and 48 hours, postoperatively (p < 0.01) and in flexion gain, 24 hours after surgery (p = 0.03). There were no significant differences between the groups in the haemoglobin evaluation 24 hours postoperatively, in pain assessment 7 days, 21 days and 2 months, postoperatively, in flexion gain 48 hours, 7 days, 21 days and 2 months, postoperatively and in WOMAC after 2 months.Conclusion:In addition to reducing bleeding, topical TXA improved pain and increased flexion gain in the first hours after TKA.Trial Registration:RBR-9b4qgq
Relation of Plasma Obestatin Levels with BMI and HOMA-IR in Syrian Obese Patients with Type 2 Diabetes
Authors: Alhalbouni Hiba , Kabalan Youns , Alquobaili Faizeh 
Published: September 2017

Background:Obestatin is a novel hormone derived from preproghrelin, which was reported to inhibit appetite and gastric motility.Study Aim:This study aimed to investigate plasma obestatin levels in obese patients with T2D patients, which had not been studied clearly in last researches.Methods:23 normal weight subjects, 35 obese subjects and 31 obese patients with T2D participated in the study, the body mass index was calculated. Fasting glucose and insulin levels were measured and the homeostasis model assessment of insulin resistance (HOMA-IR) was determined. Plasma obestatin levels were measured with enzyme-linked immune sorbent assay (ELISA). The relationship between plasma obestatin levels and biochemical parameters was also analyzed.Results:Fasting obestatin was significantly lower in obese patients with T2D, comparing to control subjects (mean=6.35 vs12.38ng/ml) and to the non-patients obese group (mean=6.35 vs 7.76 ng/ml). Obestatin levels correlated significantly and negatively with BMI (R=-0. 451; P=0. 01), basal insulin levels (R=-0.737, P<0.0001) and HOMA-IR (R=-0. 764, P<0.0001) in diabetic patients.Conclusion:Our results suggest that obestatin may contribute to body weight regulation, and insulin sensitivity could be affected by obestatin levels.
Comparative effectiveness of the biosimilar CT-P13
Authors: Yoo Dae Hyun 
Published: September 2017

The first biosimilar infliximab, CT-P13 (infliximab-dyyb) has been used for the treatment of inflammatory diseases for 4 years. CT-P13 has highly similar efficacy and safety profiles with a lower price than the originator infliximab and has been approved in 81 countries. Despite approval for clinical use, some knowledge gaps still limit the widespread and pertinent use of biosimilar CT-P13. One of the most important factors for proper utilization of CT-P13 for the treatment of immune-mediated inflammatory diseases is confidence in CT-P13, which could be enhanced by scientific evidence supporting the biosimilarity of CT-P13. Overall, five randomized controlled studies have been performed. For the other extrapolated indications, many observational induction and switching studies also support the utility of CT-P13 in the treatment of inflammatory diseases. Here, we review profiles of CT-P13 including physicochemical properties, clinical efficacy and safety data in all indications and current status.
Um modelo teórico de Matemática para o Ensino do Conceito de Função a partir de realizações em livros didáticos <br> A theoretical model of Mathematics for Teaching of the concept of function from realizations in textbooks
Authors: Santos Graça Luzia Dominguez , Barbosa Jonei Cerqueira 
Published: September 2017

ResumoNesse estudo, construímos um modelo teórico de Matemática para o Ensino do Conceito de Função a partir de uma perspectiva discursiva. Utilizamos como fonte de dados para construção do modelo duas coleções de livros didáticos. O modelo está estruturado em categorias de realizações (panoramas) do conceito de função, que foram sistematizados empregando como parâmetro a convergência das regras de reconhecimento e realização. Os panoramas que compõem o modelo são: tabular, diagrama, algébrico, gráfico, generalização de padrões e formal. O modelo construído explicita as formas de reconhecer, selecionar e produzir textos legítimos dentro de cada panorama, designando suas potencialidades e limitações comunicativas, podendo, desse modo, servir como quadro analítico para pesquisas sobre o ensino e a aprendizagem de função.AbstractIn this study, we build a theoretical model of mathematics for teaching of the concept of function from a discursive perspective. Two collections of textbooks were used as data source. The theoretical model is structured around the realizations of the concept of function identified in such textbooks categorized in which we call landscapes. By identifying recognition and realization rules, we were able to structure the landscapes. The following were found: tabular, diagram, algebraic, graphical, generalization of patterns and formal. The model explains how to recognize, select and produce legitimate texts within each landscape, as well as describing their communicative affordances and limitations. The result is expected to be used as framework for researches about teaching and learning function.
A contextualização no ensino de matemática: concepções e práticas <br> Contextualizationin the teaching of mathematics: conceptions and practices
Authors: Reis Ana Queli , Nehring Cátia Maria 
Published: September 2017

Resumo Este artigo objetiva apresentar um panorama sobre a contextualização através de uma meta análise de pesquisas que tratam deste conceito. Consideramos pesquisas que abordam a contextualização a partir de sua proposição pelas políticas públicas, através de documentos, livros didáticos e avaliações, bem como as concepções e práticas desenvolvidas por professores e pesquisadores da educação matemática. As análises evidenciam um distanciamento entre o que é compreendido epistemologicamente e a prática em sala de aula. A fragilidade de entendimentos sobre o que é contextualização tem limitado o ensino à resolução de problemas e aplicação, simplificando conceitos no processo de ensino e aprendizagem por não enfatizarem o processo de abstração decorrente da contextualização. Abstract This paper aims to present an overview of the contextualization through a meta-analysis of researches, which deal with this concept. We consider researches that address the contextualization from its proposition by public policies through documents, textbooks and assessments, as well as the conceptions and practices developed by teachers and researchers of mathematics education. The analyses have shown a gap between what is epistemologically understood and practice in the classroom. The weakness in understanding what is contextualization has limited teaching to problem solving and application, simplifying concepts in the process of teaching and learning due to not emphasizing the abstraction process arising from the contextualization.
“Vygotsky’s Inner Speech” Ajuda na solução de problemas matemáticos em TICs? <br> "Vygotsky's Inner Speech" Does it help in the solution of mathematical problems with the use of ICTs?
Authors: Guilherme Alexandre , Brenner Cristian Bobsin 
Published: September 2017

ResumoApós extensa e inconclusiva pesquisa bibliográfica por replicações de um estudo de Berk (1994) que relatou positivamente a relação entre o uso do Inner Speech, tão argumentado por Vygotsky, e o sucesso na resolução de problemas em crianças viu-se a oportunidade de elaborar um novo estudo, desta vez utilizando uma amostragem diferente de participantes composta em sua totalidade por alunos do curso de Matemática da PUCRS. Assim, fazendo uso de uma TIC, propomos investigar se há correlação entre o uso do Inner Speech e o sucesso na resolução de problemas matemáticos mesmo após a infância. A análise estatística usando SPSS resultou no valor-p 0,0357 e assim a hipótese nula (“Vygotsky’s Inner Speech não ajuda na solução de problemas matemáticos em TICs?) pode ser rejeitada.AbstractAfter extensive and inconclusive bibliographical research by replications of a study by Berk (1994) that reported positively the relationship between the use of the Inner Speech, so argued by Vygotsky, and children’s success in solving problems, we realized that there was an opportunity to elaborate a new study. However, this time using a different sample of participants that is composed in its entirety by students of the Faculty of Mathematics at PUCRS. Thus, making use of an ICT, we proposed to investigate if there is a correlation between the use of Inner Speech and the success in solving mathematical problems even after childhood. Statistical analysis using SPSS resulted in a p-value 0.0357 and therefore the null hypothesis ("Vygotsky's Inner Speech does not help solve mathematical problems in ICTs?") can be rejected.
UPAYA PENCEGAHAN HIV/AIDS PADA KALANGAN REMAJA DI KOTA BANDUNG
Authors: Santoso Meilanny Budiarti , Apsari Nurliana Cipta , Nabila Annisa 
Published: September 2017

Masalah HIV/AIDS menjadi masalah kontemporer yang berkaitan dengan perilaku berisiko manusia, karena masalah ini bukanlah masalah kesehatan semata. Orang dengan HIV/AIDS (ODHA) termasuk populasi yang rentan bermasalah secara sosial, ekonomi, budaya dan politik. Sejak tahun 2005, sosialisasi tentang bahaya HIV/AIDS yang merupakan salah satu wujud upaya pencegahan HIV/AIDS, sebetulnya sudah mulai masuk ke setiap SMA, namun, karena HIV/AIDS banyak menyerang usia produktif, termasuk pelajar, sehingga sosialisasi diharapkan tidak hanya dilakukan pada para pelajar SMA saja, melainkan juga dilakukan pada para pelajar di tingkat pendidikan yang lebih rendah lagi, yaitu SMP dengan harapan dapat mencegah lebih banyak remaja yang terlibat dalam perilaku seksual yang beresiko dan penyalahgunaan narkoba.Penelitian ini menggunakan pendekatan penelitian kuantitatif dengan jenis penelitian survei. Metode yang digunakan dalam penelitian ini adalah eksplanatory survey. Populasi dari penelitian ini adalah siswa-siswi SMPN 35 Bandung yang telah mendapat program HEBAT secara penuh 2 semester.Program HEBAT! menjadi pelopor program pencegahan HIV/AIDS yang diperuntukkan bagi remaja di tingkat Sekolah Menengah Pertama (SMP). Program HEBAT! berbentuk kurikulum (mata pelajaran) yang berlangsung selama 2 semester di kelas VIII SMP. Sejak pertengahan tahun 2010, program HEBAT hingga saat ini telah berlangsung di 33 SMP di Kota Bandung. Berdasarkan data yang diperoleh dalam penelitian ini, terdapat pengaruh antara pelaksanaan program HEBAT terhadap sikap remaja. Pendidikan yang diberikan pada remaja dalam program HEBAT adalah sebagai langkah untuk meningkatkan pengetahuan remaja terkait bahaya narkoba dan pentingnya menjaga kesehatan reproduksi sejak dini agar mereka terhindar dari perilaku berisiko HIV/AIDS
Understanding Adolescent Low Back Pain From a Multidimensional Perspective: Implications for Management
Authors: O'Sullivan Peter , Smith Anne , Beales Darren , Straker Leon 
Published: September 2017

Synopsis Low back pain (LBP) is the leading cause of disability worldwide. It often begins in adolescence, setting a course for later in life. We have tracked the course of LBP in the Raine Study cohort from the age of 14 years into early adulthood. Our work has found that LBP is already prevalent in individuals at 14 years of age and increases throughout adolescence and into early adulthood. It is often comorbid with other musculoskeletal pain. For some adolescents, LBP has little impact; for others, its impact includes care seeking, taking medication, taking time off from school and work, as well as modifying physical and functional activity. Of concern is the increasing prevalence of LBP with impact across adolescence, reaching adult rates by 22 years of age. The predictors of disabling LBP in adolescence are multidimensional. They include female sex, negative back pain beliefs, poor mental health status, somatic complaints, involvement in sports, and altered stress responses. Genetics also plays a role. Ironically, the factors that we have historically thought to be important predictors of LBP, such as “poor” spinal posture, scoliosis, carrying school bags, joint hypermobility, and poor back muscle endurance, are not strong predictors. This challenges our clinical beliefs and highlights that adolescent LBP needs a flexible and targeted multidimensional approach to assessment and management. In most cases, we recommend a cognitive functional approach that challenges negative LBP beliefs, educates adolescents regarding factors associated with their LBP, restores functional capacity where it is impaired, and encourages healthy lifestyle habits. J Orthop Sports Phys Ther 2017;47(10):741–751. Epub 12 Sep 2017. doi:10.2519/jospt.2017.7376
PERSPEKTIF LANSIA TERHADAP AKTIVITAS FISIK DAN KESEJAHTERAAN JASMANI DI DESA MARGOSARI KOTA SALATIGA JAWA TENGAH
Authors: Baga Hezron Dwi Setiantwo , Sujana Treesia , Triwibowo Antonius 
Published: September 2017

Jumlah lansia di Indonesia terus meningkat terkhususnya Provinsi Jawa Tengah yang menempati urutan ketiga se-Indonesia dengan persentase 10,35% dari 18,55 juta jiwa lansia di Indonesia pada tahun 2012 dan diprediksi akan terus meningkat. Hal ini menimbulkan perhatian penting terhadap bidang kesehatan lansia untuk meningkatkan kualitas hidupnya. Salah satunya adalah aktivitas fisik lansia dimana aktivitas fisik sangat berkaitan erat dengan kesejahteraan jasmani lansia. Tujuan penelitian ini adalah mengetahui bagaimana perspektif lansia terhadap aktivitas fisik yang dilakukan oleh lansia dan kaitanya dengan kesejahteraan jasmaninya di Desa Margosari Kota Salatiga Jawa Tengah. Metode penelitian yang digunakan adalah kualitatif deskriptif. Penelitian ini akan dilakukan di Desa Margosari Kota Salatiga Jawa Tengah pada Januari hingga Maret 2017. Partisipan dalam penelitian ini berjumlah 5 orang yang di dapatkan dengan menggunakan teknik purposive sampling. Teknik pengumpulan data pada penelitian ini adalah in-depth interview. Penelitian ini menggunakan analisa data model Miles dan Humberman. Hasil penelitian ini adalah kegiatan aktivitas fisik yang dilakukan oleh lansia di Desa Margosari memiliki kaitan dengan kesejahteraan jasmani setiap individu dimana mereka masih mampu melakukan aktivitas secara mandiri tanpa alat bantu. Selain itu lansia pada umumnya memiliki motivasi yang baik untuk selalu ingin bergerak agar tetap sehat bugar dan bersemangat.
FAKTOR-FAKTOR YANG BERKORELASI DENGAN KADAR ANTIBODI ANTITETANUS PADA IBU HAMIL
Authors: Merry Yussie Ater , Suharti Netti 
Published: September 2017

Kadar antibodi antitetanus pada ibu hamil dipengaruhi berbagai faktor, yaitu: umur, interval vaksinasi Tetanus toksoid (TT)-1 – TT-2, TT-1, TT-2 – waktu pemeriksaan dan kadar Hb. Penelitian ini bertujuan untuk mengetahui faktor – faktor yang berkorelasi dengan kadar antibodi antitetanus pada ibu hamil. Disain penelitian cross sectional, observasional terhadap 67 ibu hamil di wilayah kerja puskesmas Lubuk Buaya, Nanggalo dan Ambacang Kuranji kota Padang, bulan Juni - Desember 2015, teknik consecutive sampling. Kadar antibodi diukur menggunakan metode Indirect ELISA di Laboratorium Biomedik Universitas Andalas. Uji normalitas data dengan Kolmogorov-Smirnov, Spearman untuk korelasi antara umur, interval: TT-1 – TT-2, TT-1, TT-2 – waktu pemeriksaan, kadar Hb dengan kadar antibodi dan uji Kruskal Walis untuk menilai perbedaan kadar antibodi berdasar interval TT-1 – waktu pemeriksaan serta uji regresi linier untuk menentukan faktor determinan yang berkorelasi dengan kadar antibodi.Hasil penelitian menunjukkan terdapat korelasi negatif yang sangat lemah, tidak signifikan antara umur dengan kadar antibodi (r=-0,076 p=0,540), terdapat korelasi positif lemah dan signifikan antara: interval TT-1 – TT-2 (r= 0,353, p = 0,003), korelasi positif kuat dan signifikan antara TT-1, TT-2 waktu pemeriksaan (r=0,696 p = 0,000 dan r= 0,729 p= 0,000) dengan kadar antibodi. Terdapat korelasi positif sangat lemah antara kadar Hb dengan kadar antibodi (r=0,200 p=0,104). Kesimpulan penelitian, faktor determinan yang berkorelasi dengan kadar antibodi antitetanus adalah: interval TT-1 – TT-2 dan TT-2 – waktu pemeriksaan
Comorbidity Analysis between Alzheimer’s Disease and Type 2 Diabetes Mellitus (T2DM) Based on Shared Pathways and the Role of T2DM Drugs
Authors: Karki Reagon , Kodamullil Alpha Tom , Hofmann-Apitius Martin 
Published: September 2017

Background: Various studies suggest a comorbid association between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) indicating that there could be shared underlying pathophysiological mechanisms. Objective: This study aims to systematically model relevant knowledge at the molecular level to find a mechanistic rationale explaining the existing comorbid association between AD and T2DM. Method: We have used a knowledge-based modeling approach to build two network models for AD and T2DM using Biological Expression Language (BEL), which is capable of capturing and representing causal and correlative relationships at both molecular and clinical levels from various knowledge resources. Results: Using comparative analysis, we have identified several putative “shared pathways”. We demonstrate, at a mechanistic level, how the insulin signaling pathway is related to other significant AD pathways such as the neurotrophin signaling pathway, PI3K/AKT signaling, MTOR signaling, and MAPK signaling and how these pathways do cross-talk with each other both in AD and T2DM. In addition, we present a mechanistic hypothesis that explains both favorable and adverse effects of the anti-diabetic drug metformin in AD. Conclusion: The two computable models introduced here provide a powerful framework to identify plausible mechanistic links shared between AD and T2DM and thereby identify targeted pathways for new therapeutics. Our approach can also be used to provide mechanistic answers to the question of why some T2DM treatments seem to increase the risk of AD.
App-Based Bradykinesia Tasks for Clinic and Home Assessment in Parkinson’s Disease: Reliability and Responsiveness
Authors: Heldman Dustin A. , Urrea-Mendoza Enrique , Lovera Lilia C. , Schmerler David A. , Garcia Xiomara , Mohammad Mohammad E. , McFarlane Maria Catalina U. , Giuffrida Joseph P. , Espay Alberto J. , Fernandez Hubert H. 
Published: September 2017

Background: Clinical rating of bradykinesia in Parkinson disease (PD) is challenging as it must combine several movement features into a single score. Additionally, in-clinic assessment cannot capture fluctuations throughout the day. Objective: To evaluate the reliability and responsiveness of a motion sensor-based tablet app for objective bradykinesia assessment in clinic and at home as compared to clinical ratings. Methods: Thirty-two PD patients treated with subthalamic deep brain stimulation (DBS) were outfitted with a motion sensor on the index finger of the more affected hand to perform two repetitions of finger-tapping, hand opening-closing, and arm pronation-supination tasks with DBS on and 10, 20, and 30 minutes after turning DBS off. Tasks were videotaped for blinded clinician rating using the Modified Bradykinesia Rating Scale (MBRS). Participants were then sent home with an app-based system to perform two repetitions of the same tasks six times per day spaced two hours apart, three days per week, for two weeks. Intraclass correlation (ICC) and minimal detectable change (MDC) were calculated. Results: As the effects of DBS wore off, motion sensors detected worsening of amplitude sooner than did clinician-rated MBRS for all three tasks. ICCs were significantly higher and MDCs were significantly lower for motion sensors in the clinic and at home than for clinician ratings ( p < 0.01). Conclusions: The tablet-based app demonstrated higher reliability and responsiveness in capturing bradykinesia-related tasks in the clinic and at home than did clinician ratings. This tool may enhance the assessment of novel therapies.
On the Prospects of Gamma-Ray Burst Detection in the TeV Band
Authors: Vurm Indrek , Beloborodov Andrei M. 
Published: September 2017

Abstract
A gamma-ray burst (GRB) jet running into an external medium is expected to generate luminous GeV–TeV emission lasting from minutes to several hours. The high-energy emission results from inverse Compton upscattering of prompt and afterglow photons by shock-heated thermal plasma. At its peak the high-energy radiation carries a significant fraction of the power dissipated at the forward shock. We discuss in detail the expected TeV luminosity, using a robust “minimal” emission model. Then, using the statistical properties of the GRB population (luminosity function, redshift distribution, afterglow energy), we simulate the expected detection rates of GRBs by current and upcoming atmospheric Cherenkov instruments. We find that GRBs exploding into a low-density interstellar medium must produce TeV emission that would have already been detected by the currently operating Cherenkov telescopes. The absence of detections is consistent with explosions into a dense wind of the GRB progenitor. If, as suggested by the recent analysis of Fermi LAT data, the typical environment of long GRBs is a Wolf–Rayet progenitor wind with the density parameter

g cm−1, then 10%–20% of the bursts that trigger the space-borne detectors should also be detectable by the upcoming Cherenkov Telescope Array (CTA) under favorable observing conditions. Since absorption by the extragalactic background light limits the detectability above 0.1 TeV for all but the most nearby bursts (

), the reduced energy threshold of CTA is the key improvement over current instruments, which should increase the number of detectable bursts by at least a factor of 3 compared with currently operating facilities.