bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absolute values of lung function explain the sex difference in breathlessness in the general population
Authors: Ekström Magnus , Schiöler Linus , Grønseth Rune , Johannessen Ane , Svanes Cecilie , Leynaert Benedicte , Jarvis Deborah , Gislason Thorarinn , Demoly Pascal , Probst-Hensch Nicole , Pin Isabelle , Corsico Angelo G. , Forsberg Bertil , Heinrich Joachim , Nowak Dennis , Raherison-Semjen Chantal , Dharmage Shyamali C. , Trucco Giulia , Urrutia Isabel , Martinez-Moratalla Rovira Jesús , Sánchez-Ramos José Luis , Janson Christer , Torén Kjell 
Published: May 2017

Activity-related breathlessness is twice as common among females as males in the general population and is associated with adverse health outcomes. We tested whether this sex difference is explained by the lower absolute forced expiratory volume in 1 s (FEV1) or forced vital capacity (FVC) in females.This was a cross-sectional analysis of 3250 subjects (51% female) aged 38−67 years across 13 countries in the population-based third European Community Respiratory Health Survey. Activity-related breathlessness was measured using the modified Medical Research Council (mMRC) scale. Associations with mMRC were analysed using ordered logistic regression clustering on centre, adjusting for post-bronchodilator spirometry, body mass index, pack-years smoking, cardiopulmonary diseases, depression and level of exercise.Activity-related breathlessness (mMRC ≥1) was twice as common in females (27%) as in males (14%) (odds ratio (OR) 2.21, 95% CI 1.79−2.72). The sex difference was not reduced when controlling for FEV1% predicted (OR 2.33), but disappeared when controlling for absolute FEV1(OR 0.89, 95% CI 0.69−1.14). Absolute FEV1explained 98−100% of the sex difference adjusting for confounders. The effect was similar within males and females, when using FVC instead of FEV1and in healthy never-smokers.The markedly more severe activity-related breathlessness among females in the general population is explained by their smaller spirometric lung volumes.
Health-related quality of life and risk factors associated with spirometric restriction
Authors: Guerra Stefano , Carsin Anne-Elie , Keidel Dirk , Sunyer Jordi , Leynaert Bénédicte , Janson Christer , Jarvis Debbie , Stolz Daiana , Rothe Thomas , Pons Marco , Turk Alexander , Anto Josep M. , Probst-Hensch Nicole 
Published: May 2017

The restrictive spirometric pattern is associated with a substantial morbidity and mortality burden. We sought to determine to what extent spirometric restriction is associated with impaired quality of life.We used data from two large population-based European cohorts: 6698 European Community Respiratory Health Survey (ECRHS) and 6069 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) adult participants. The restrictive pattern was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ≥lower limit of normal (LLN) and FVC <LLN; an obstructive pattern was defined as FEV1/FVC <LLN independent of FVC. The Physical Component Summary and Mental Component Summary of quality of life were computed using the Short Form-36 questionnaire.In both cohorts, the restrictive pattern was associated with heavy smoking, being underweight or obese and the coexistence of respiratory symptoms. In univariate analyses, compared with the normal group, both the restrictive and obstructive pattern had significant Physical Component Summary deficits (−2.77 and −2.08, respectively, in ECRHS; −3.25 and −2.14, respectively, in SAPALDIA; all p-values <0.001). However, in models adjusted for sex, age, education, body mass index, smoking, comorbidities and respiratory symptoms, only the restrictive pattern remained significantly associated with Physical Component Summary deficits (p=0.004 in ECRHS; p=0.001 in SAPALDIA).The restrictive spirometric pattern is associated with deficits in the physical component of quality of life that are partly independent of the presence of respiratory symptoms.
Evaluasi Rehabilitasi Hutan dan Lahan ( RHL ) di Daerah Aliran Sungai ( DAS ) Juwana pada Kawasan Gunung Muria Kabupaten Pati
Authors: Surtiani Yohan , Budiati Lilin 
Published: May 2017

Penelitian ini bertujuan mengembangkan model evaluasi program RHL pada DAS Juwana Kawasan Gunung Muria khususnya Desa Klakahkasihan, Plukaran, Bageng, Sitiluhur Kecamatan Gembong Kabupaten Pati serta mengetahui posisi lembaga Dinas Kehutanan dan Perkebunan Kabupaten Pati sebagai lembaga pemerintah yang bertanggungjawab dalam program RHL. Penelitian ini menunjukkan persen capaian program RHL pada DAS Juwana Kawasan Gunung Muria Kabupaten Pati sebesar 65,8 %. Capaian tersebut terdiri dari ( 1 ) Prasyarat Pelaksanaan Program RHL Berkelanjutan ( 10% ) , ( 2 ) Pengelolaan berbasis ekologi dan perlindungan Sumber Daya ( 29% ) , ( 3 ) Sistem Produksi hutan lestari ( 4% ) , ( 4 ) Peningkatan Partisipasi dan Sosial Ekonomi masyarakat ( 34% ) , ( 5 ) Implementasi Kebijakan RHL ( 23% ) . Posisi lembaga Dinas Kehutanan dan Perkebunan Kabupaten Pati berada pada posisi grow and build ( pertumbuhan dan membangun ) . Disarankan kedepan Dinas Kehutanan dan Perkebunan Kabupaten Pati melakukan perbaikan strategi pelaksanaan RHL yaitu ( 1 ) Penguatan kelembagaan, ( 2 ) Pengembangan jejaring kerja dan integrasi program & kebijakan lintas sektor dan lintas organisasi untuk pengembangan pelayanan publik.Kata kunci : evaluasi, RHL, co-management, DAS terpadu , stakeholders, kelembagaan
Influence of smooth muscle contractility by inhibition of crac channels activity
Authors: Kocmálová M. , Kazimierová I. 
Published: May 2017

Abstract
The present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human term-pregnant and non-pregnant myometrium. The expression of Orai1 protein, as a functional subunit of CRAC channel, was significantly higher than in non-pregnant myometrium. Lower Orai1 protein expression did not influence the amplitude of contractile response of term-pregnant myometrium, but higher Orai1 expression observed in non-pregnant myometrium was related to the different influence of CRAC blocker on contraction frequency.
The Halosphaeriaceae revisited
Authors: Jones E.B. Gareth , Ju Wen-Ting , Lu Cheng-Lun , Guo Sheng-Yu , Pang Ka-Lai 
Published: May 2017

AbstractThe Halosphaeriaceae is a monophyletic group that shares a common ancestor with Microascaceae and, along with the families Graphiaceae, Ceratocystidiaceae, Chadefaudiellaceae and Gondwanamycetacea, is referred to the order Microascales. It constitutes the largest family in Microascales with 63 genera (166 species) and differs from other families in that most species are aquatic (predominantly marine) and characterised by perithecial ascomata, centrum tissue comprising catenophyses, clavate to fusiform asci that generally deliquesce early, hyaline, unicellular to many times septate ascospores usually with appendages. Although approximately 75% of halosphaeriaceous species have been sequenced, their phylogenetic grouping based on morphological features is not supported. This indicates that certain characters have evolved and been lost several times. New sequences have been generated in this study; a phylogenetic analysis based on the 18S and 28S rDNA was run to determine phylogenetic relationships between genera, and pairwise distance of the partial 28S rDNA was calculated.
Hermite Pseudospectral Method for the Time Fractional Diffusion Equation with Variable Coefficients
Authors: Liu Zeting , Lü Shujuan 
Published: May 2017

Abstract:We consider the initial value problem of the time fractional diffusion equation on the whole line and the fractional derivative is described in Caputo sense. A fully discrete Hermite pseudospectral approximation scheme is structured basing Hermite-Gauss points in space and finite difference in time. Unconditionally stability and convergence are proved. Numerical experiments are presented and the results conform to our theoretical analysis.
PoesiAHA! 1 Ao enfermeiro-criativo
Authors: Silva Onã 
Published: May 2017

Poesia dedicada ao Dr. Elioenai Dornelles Alves em reconhecimento ao seu trabalho inovador no campo da enfermagem. Profissional que se destaca pelo trabalho de semear e promover ações criativas no cuidado de enfermagem.
Association of Preventive Maintenance Therapy Compliance and Peri‐Implant Diseases: A Cross‐Sectional Study
Authors: Monje Alberto , Wang Hom‐Lay , Nart José 
Published: May 2017

Background: This study aims to investigate association between peri‐implant maintenance therapy (PIMT) and the frequency of peri‐implant diseases and to further identify factors that contribute to failure of PIMT compliance.Methods: A cross‐sectional study on patients who were healthy and partially edentulous was conducted. They were grouped in the following categories according to PIMT compliance: 1) regular compliers (RC) (≥2 PIMT/year); 2) erratic compliers (EC) (<2 PIMT/year); and 3) non‐compliers (NC) (no PIMT). Radiographic and clinical analyses were carried out including probing depth (PD), plaque index (PI), bleeding on probing (BOP), mucosal redness (MR), suppuration (SUP), keratinized mucosa dimension, and marginal bone loss. A multiple logistic regression model was estimated at implant and patient level to obtain adjusted odds ratios (ORs) and to control possible confounding effects among variables.Results: Overall, 206 implants in 115 patients fulfilled inclusion criteria. At patient level, it was shown that association between compliance and peri‐implant condition was statistically significant (P = 0.04). Compliance was associated with 86% fewer conditions of peri‐implantitis. The probability of PIMT compliance was substantially associated with frequency of peri‐implantitis (OR = 0.13, P = 0.01). Patients with a history of periodontal disease multiplied their probability of being EC (versus NC) 4.23 times with respect to not having a history of periodontal disease (P = 0.02). Moreover, light smokers significantly resulted to be NC compared with RC (P = 0.04) and EC (P = 0.02). Nevertheless, mucositis was not found to be statistically associated with level of compliance. In addition, PD, PI, BOP, MR, and SUP varied significantly according to PIMT compliance and peri‐implant condition.Conclusions: Peri‐implant maintenance compliance ≥2 PIMT/year seems to be crucial to prevent peri‐implantitis in healthy patients. Furthermore, history of periodontal disease and disease severity, as well as its extent and a smoking habit, appear to be factors that influence the compliance risk profile (NCT02789306).
Metformin Inhibits Porphyromonasgingivalis Lipopolysaccharide‐Influenced Inflammatory Response in Human Gingival Fibroblasts via Regulating Activating Transcription Factor‐3 Expression
Authors: Kang Wenyan , Wang Ting , Hu Zhekai , Liu Feng , Sun Yundong , Ge Shaohua 
Published: May 2017

Background: Chronic periodontitis, one of the most prevalent oral diseases, is associated with Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) infection and has profound effects on type 2 diabetes mellitus (t2DM). Metformin, a well‐known antidiabetic agent, has been reported to exert anti‐inflammatory effects on various cells. This study aims to investigate the role of metformin on LPS‐influenced inflammatory response in human gingival fibroblasts (HGFs).Methods: Dose‐dependent additive effects of metformin on LPS‐influenced HGFs were detected. Cell‐counting assay was used to determine effects of metformin and LPS on viability of HGFs. Enzyme‐linked immunosorbent assay and quantitative real‐time polymerase chain reaction (qRT‐PCR) were applied to detect levels of interleukin (IL)‐1β, IL‐6, and tumor necrosis factor (TNF)‐α in differently treated cells. Activating transcription factor‐3 (ATF3) small interfering (si)RNA transfection was used to determine the mechanism of metformin action, and the transfection efficiency was observed by fluorescence microscope. Effects of ATF3 knockdown were determined by qRT‐PCR and Western blot.Results: Results showed that 5 μg/mL Pg LPS and 0.1, 0.5, and 1 mM metformin exhibited no toxicity to HGFs, and metformin inhibited LPS‐influenced IL‐1β, IL‐6, and TNF‐α production in a dose‐dependent manner. Metformin and LPS could synergistically facilitate ATF3 expression, and ATF3 knockdown abolished inhibitory effects of metformin on LPS‐influenced inflammatory cytokine production in HGFs.Conclusion: The present study confirms that metformin suppresses LPS‐enhanced IL‐6, IL‐1β, and TNF‐α production in HGFs via increasing ATF3 expression.
Albuminuria, Proteinuria, and Renal Disease Progression in Children with CKD
Authors: Fuhrman Dana Y. , Schneider Michael F. , Dell Katherine M. , Blydt-Hansen Tom D. , Mak Robert , Saland Jeffrey M. , Furth Susan L. , Warady Bradley A. , Moxey-Mims Marva M. , Schwartz George J. 
Published: May 2017

Background and objectives
The role of albuminuria as an indicator of progression has not been investigated in children with CKD in the absence of diabetes.

Design, setting, participants, & measurements
Children were enrolled from 49 centers of the CKD in Children study between January of 2005 and March of 2014. Cross-sectional multivariable linear regression (n=647) was used to examine the relationship between urine protein-to-creatinine (UP/C [milligrams per milligram]) and albumin-to-creatinine (ACR [milligrams per gram]) with eGFR (milliliters per minute per 1.73 m2). Parametric time-to-event analysis (n=751) was used to assess the association of UP/C, ACR, and urine nonalbumin-to-creatinine (Unon-alb/cr [milligrams per gram]) on the time to the composite endpoint of initiation of RRT or 50% decline in eGFR.

Results
The median follow-up time was 3.4 years and 202 individuals experienced the event. Participants with a UP/C≥0.2 mg/mg and ACR≥30 mg/g had a mean eGFR that was 16 ml/min per 1.73 m2 lower than those with a UP/C<0.2 mg/mg and ACR<30 mg/g. Individuals with ACR<30 mg/g, but a UP/C≥0.2 mg/mg, had a mean eGFR that was 9.3 ml/min per 1.73 m2 lower than those with a UP/C<0.2 mg/mg and ACR<30 mg/g. When categories of ACR and Unon-alb/cr were created on the basis of clinically meaningful cutoff values of UP/C with the same sample sizes for comparison, the relative times (RTs) to the composite end-point were almost identical when comparing the middle (RT=0.31 for UP/C [0.2–2.0 mg/mg], RT=0.38 for ACR [56–1333 mg/g], RT=0.31 for Unon-alb/cr [118–715 mg/g]) and the highest (RT=0.08 for UP/C [>2.0 mg/mg], RT=0.09 for ACR [>1333 mg/g], RT=0.07 for Unon-alb/cr [>715 mg/g]) levels to the lowest levels. A similar trend was seen when categories were created on the basis of clinically meaningful cutoff values of ACR (<30, 30–300, >300 mg/g).

Conclusions
In children with CKD without diabetes, the utility of an initial UP/C, ACR, and Unon-alb/cr for characterizing progression is similar.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_05_30_Schwartz.mp3
Lógica FUZZY e técnica sam para modelagem previsional do ouro no setor oeste da província mineral do tapajós usando dados aerogeofísicos e de sensoriamento remoto
Authors: Carrino Thais Andressa , Silva Adalene Moreira , Botelho Nilson Francisquini , Silva Alexandre Augusto Cardoso da 
Published: May 2017

A Província Mineral do Tapajós (PMT) compreende a maior província aurífera do Brasil e localiza-se na parte centro-sul do Cráton Amazônico. A PMT é caracterizada por unidades litoestratigráficas paleoproterozoicas que hospedam mineralizações auríferas de mesma idade. Com base neste potencial mineral, este artigo objetivou o processamento e a modelagem espacial de dados aerogeofísicos regionais (levantamento Bloco I – Província Aurífera do Tapajós) e de sensoriamento remoto (SAR-R99B e TM/Landsat 5) disponíveis para a geração de mapas de favorabilidade aurífera do setor oeste da PMT. Para tal, imagens da razão K/eTh e do parâmetro F foram produzidas no intuito de se realçar o enriquecimento de K. Imagem de buffers de lineamentos, interpretados através de imagens magnetométricas, SAR-R99B e do sensor TM, foi gerada para a interpretação de componentes estruturais relevantes. Empregando-se estes produtos, além do mapa geológico regional disponibilizado no projeto PROMIN-Tapajós, foi utilizada a técnica lógica fuzzy e o classificador Spectral Angle Mapper objetivando a produção de mapas previsionais de ouro. Ocorrências de ouro atualmente conhecidas foram usadas para a validação dos resultados e uma discussão sobre o desempenho da geração de mapas previsionais regionais em terrenos com baixo conhecimento geológico foi realizada.
MODAL INVERSION BY USING PARAMETERIZATION WITH CHEBYSHEV POLYNOMIALS
Authors: Marin Fernando De Oliveira , Rodríguez Orlando Camargo , Guimarães Luiz Gallisa , Ribeiro Carlos Eduardo Parente 
Published: May 2017

ABSTRACT. This paper discusses the estimation of sound speed perturbations in a shallow water waveguide, from measurements of modal travel times. The formulation of the Inverse Problem is reduced to a least squares solution, being highlighted that the choice of discretization of the set of model parameters is of fundamental importance. In the...Keywords: shallow water, tomography, orthogonal functions. RESUMO. Este trabalho aborda a estimativa de perturbações de velocidade do som em um ambiente de águas rasas, a partir de medições de tempo de percurso modal. A formulação do Problema Inverso é reduzida a uma solução por mínimos quadrados, sendo destacado que a escolha da discretização do conjunto de parâmetros do modelo é de fundamental...Palavras-chave: águas rasas, tomografia, funções ortogonais.
El bestiario del empiorador. Notas sobre la caricatura republicana durante la Intervención y el Segundo Imperio
Authors: Torre Hernández Alejandro de la 
Published: May 2017

Este artículo explora algunas de las más significativas expresiones de la caricatura republicana durante la época de la Intervención francesa y el Segundo Imperio. Pone particular atención a las representaciones de monstruos y criaturas zoomorfas que habitaban el imaginario de la sátira política de mediados del siglo XIX, analizando los usos de la imagen como elementos cruciales de la propaganda, la lucha política y la confrontación de proyectos de nación. Así, el artículo propone un recorrido iconográfico por una singular galería de deformidades que fungían como retratos bufos de la escena política y de la sociedad, a la vez que exponían un enjuiciamiento moral de la convulsa situación nacional.
In-service EFL Teacher Development for Technology Integration in Communicative Language Teaching
Authors: Kwangsawad Thooptong 
Published: May 2017

In response to the challenges of ASEAN Economic Community 2015, Ministry of Education announced the latest policies to reform teaching and learning English at the basic education level adapting communicative language teaching (CLT) flexibly and appropriately to the Thai context, and using information computer technology (ICT) media as a tool to enhance teaching skills and knowledge of teachers. This article deals with the implementation and evaluation a professional development program for technology integration in CLT for 32 in-service EFL teachers from primary and secondary school levels with the foci on 1) evaluation of the in-service EFL teachers’ knowledge and skills in CLT and technology integration in CLT and, 2) the in-service EFL teachers’ experiences with participating in the program. The results show that the post- test scores of the in-service teachers’ knowledge in CLT and technology integration in CLT were significantly higher than the pre-test scores. However, their skills in CLT and technology integration in CLT were at the low level. Almost all participants reported having positive experiences with the program.
Reflexões atuais sobre a empresa individual de responsabilidade limitada
Authors: Lana Henrique Avelino 
Published: May 2017

Pretende-se de forma acadêmica, construtiva, e sem esgotar o assunto, fazer apontamentos sobre a EIRELI – Empresa Individual de Responsabilidade Limitada. Trata-se de tema inerente ao dia a dia de quem exerce atividade empresária e está relacionado diretamente ao fomento da economia de nosso país. Objetiva-se demonstrar por meio da doutrina especializada, projeto de lei e atual previsão legal, que o regime jurídico da EIRELI é sim passível de críticas técnicas e construções acadêmicas positivas, sobretudo quanto à sua denominação, necessidade de capital social mínimo totalmente integralizado, natureza da atividade exercida, eventual titularidade por pessoa jurídica e provável possibilidade de desconsideração de sua personalidade jurídica. Metodologicamente, adotar-se-á, a forma qualitativa, mediante confronto de dispositivos legais, previsão inicial do projeto de lei e doutrina.
Effect of treatment modality on in-hospital outcome in patients with subarachnoid hemorrhage: a nationwide study in Japan (J-ASPECT Study)
Authors: Kurogi Ryota , Kada Akiko , Nishimura Kunihiro , Kamitani Satoru , Nishimura Ataru , Sayama Tetsuro , Nakagawara Jyoji , Toyoda Kazunori , Ogasawara Kuniaki , Ono Junichi , Shiokawa Yoshiaki , Aruga Toru , Miyachi Shigeru , Nagata Izumi , Matsuda Shinya , Yoshimura Shinichi , Okuchi Kazuo , Suzuki Akifumi , Nakamura Fumiaki , Onozuka Daisuke , Hagihara Akihito , Iihara Koji , _ _ 
Published: May 2017

OBJECTIVEAlthough heterogeneity in patient outcomes following subarachnoid hemorrhage (SAH) has been observed across different centers, the relative merits of clipping and coiling for SAH remain unknown. The authors sought to compare the patient outcomes between these therapeutic modalities using a large nationwide discharge database encompassing hospitals with different comprehensive stroke center (CSC) capabilities.METHODSThey analyzed data from 5214 patients with SAH (clipping 3624, coiling 1590) who had been urgently hospitalized at 393 institutions in Japan in the period from April 2012 to March 2013. In-hospital mortality, modified Rankin Scale (mRS) score, cerebral infarction, complications, hospital length of stay, and medical costs were compared between the clipping and coiling groups after adjustment for patient-level and hospital-level characteristics by using mixed-model analysis.RESULTSPatients who had undergone coiling had significantly higher in-hospital mortality (12.4% vs 8.7%, OR 1.3) and a shorter median hospital stay (32.0 vs 37.0 days, p < 0.001) than those who had undergone clipping. The respective proportions of patients discharged with mRS scores of 3–6 (46.4% and 42.9%) and median medical costs (thousands US$, 35.7 and 36.7) were not significantly different between the groups. These results remained robust after further adjustment for CSC capabilities as a hospital-related covariate.CONCLUSIONSDespite the increasing use of coiling, clipping remains the mainstay treatment for SAH. Regardless of CSC capabilities, clipping was associated with reduced in-hospital mortality, similar unfavorable functional outcomes and medical costs, and a longer hospital stay as compared with coiling in 2012 in Japan. Further study is required to determine the influence of unmeasured confounders.