bluuebunny/crossref_metadata_2025_split huggingface dataset:
It Must Be My Favourite Brand: Using Retroactive Brand Replacements in Doctored Photographs to Influence Brand Preferences
Authors: Hellenthal Maria V. , Howe Mark L. , Knott Lauren M. 
Published: September 2016

SummaryWe examined whether memories for personally chosen brands could be altered by retroactive exposure to less‐liked competitor brands embedded in manipulated photographs. In addition, we investigated whether memory errors would lead to preference change for falsely remembered brands. Fifty participants were asked to compile their personal ‘brand lifestyle basket’, which was then captured in a photo showing the basket and participant. After 1 week, participants were exposed to the photograph in which some of the originally chosen brands were replaced by different brands of the same category. Results of a memory test revealed a robust misinformation effect. The analysis of premanipulation and postmanipulation preference ratings indicated a positive shift in attitude and behaviour towards falsely accepted misinformation brands. Our findings contribute to what we know about the behavioural consequences of false memories and extend the generalizability of false memory effects to what might be considered a futuristic advertising measure. Copyright © 2016 John Wiley & Sons, Ltd.
Copper(I)‐Catalyzed Asymmetric 1,3‐Dipolar [3+4] Cycloaddition of Nitrones with Azoalkenes
Authors: Wei Liang , Yao Lu , Wang Zuo‐Fei , Li Hua , Tao Hai‐Yan , Wang Chun‐Jiang 
Published: September 2016

AbstractThe first copper(I)‐catalyzed asymmetric 1,3‐dipolar [3+4] cycloaddition of nitrones with azoalkenes has been developed, affording a variety of biologically important 1,2,4,5‐oxatriazepane derivatives in good yields with exclusive regioselectivities and excellent enantioselectivities.magnified image
Recent Advances of Oxidative Radical Cross‐Coupling Reactions: Direct α‐C(sp3)–H Bond Functionalization of Ethers and Alcohols
Authors: Guo Sheng‐rong , Kumar Pailla Santhosh , Yang Minghua 
Published: September 2016

AbstractOxygen‐containing heterocycles are an important class of compounds with diverse biological activities. In recent years, direct α‐C–H functionalization of inexpensive and abundant readily available ethers and alcohols by oxidative radical cross‐coupling with different nucleophilic partners (C–H, N–H, O–H and S–S), leading to the construction of C–C and C–X (X=C, N, O, S) bonds, has emerged as one of the vital strategies among oxidative cross‐coupling reactions. Owing to the features of being atom‐economic, environmentally benign, having a simple operation and biologically properties, a series of ether α‐C(sp3)–H bond activation reactions have been developed by metal or metal‐free systems via the radical oxidative coupling pathway, since the radical oxidative coupling reactions have wide range of applications. This review aims to highlight the recent advances in direct α‐C(sp3)–H bond functionalization of ethers and alcohols via radical oxidative process.magnified image
A Convenient Ruthenium‐Catalysed α‐Methylation of Carbonyl Compounds using Methanol
Authors: Dang Tuan Thanh , Seayad Abdul Majeed 
Published: September 2016

AbstractAn efficient ruthenium catalyst is reported, for the first time, to catalyse the α‐methylation of ketones and esters using methanol as a green methylating agent. The in situ generated catalyst from the complexes [RuCp*Cl2]2 or [RuCp*Cl2]n with dpePhos provided up to quantitative yields in the presence of only 20 mol% of lithium tert‐butoxide (LiO‐t‐Bu) as a base. Regioselective mono‐ or multi‐methylation could be effectively controlled by temperature. This catalyst system was also effective for the one‐pot sequential α‐alkylation–α‐methylation of methyl ketones and conjugate reduction–α‐methylation of α,β‐unsaturated ketones to synthesise α‐branched ketones. An application of the α‐methylation of esters using the ruthenium catalyst was demonstrated for an alternative catalytic synthesis of Ketoprofen.magnified image
Vanadium‐Catalyzed Oxidative Debenzylation of O‐Benzyl Ethers at ppm Level
Authors: Urgoitia Garazi , SanMartin Raul , Herrero María Teresa , Domínguez Esther 
Published: September 2016

AbstractAn advantageous methodology for the oxidative debenzylation of ethers has been developed. Very low amounts of a catalyst system based on vanadyl acetylacetonate and a triazole type pincer ligand allow the selective oxidative cleavage of a number of O‐benzyl ethers in the presence of oxygen as the sole oxidant. The methodology tolerates a number of functional groups such as halo‐, alkoxy‐, or trifluoromethylarenes, alkyne, alkene, ether, and acetal units. Large‐scale deprotections can be also carried out by the optimized procedure, which is amenable to enantioenriched reactants as well.magnified image
Organo‐ and Iron(0) Catalysis for an Enantioselective Michael Addition–Hemiketalization–Fragmentation Sequence to Protected ω‐Hydroxy‐nitroketones
Authors: Quintard Adrien , Rodriguez Jean 
Published: September 2016

AbstractBy combining an organocatalyzed Michael addition of 1,3‐diketones to hydroxy‐nitroolefins with a subsequent, innovative iron(0)‐catalyzed fragmentation, key enantioenriched ketones possessing additional nitro and protected alcohol functions could efficiently be prepared under excellent enantiocontrol (typically 95% ee). The reaction was made possible by the discovery that photochemical activation of iron pentacarbonyl [Fe(CO)5], a cheap widely available complex, efficiently catalyzed a Claisen‐type fragmentation under mild conditions, avoiding decomposition of the intermediates and products.magnified image
A multianalytical approach to evaluate the association of 55 SNPs in 28 genes with obesity risk in North Indian adults
Authors: Srivastava Apurva , Mittal Balraj , Prakash Jai , Srivastava Pranjal , Srivastava Nimisha , Srivastava Neena 
Published: September 2016

AbstractObjectivesThe aim of the study was to investigate the association of 55 SNPs in 28 genes with obesity risk in a North Indian population using a multianalytical approach.MethodsOverall, 480 subjects from the North Indian population were studied using strict inclusion/exclusion criteria. SNP Genotyping was carried out by Sequenom Mass ARRAY platform (Sequenom, San Diego, CA) and validated Taqman® allelic discrimination (Applied Biosystems®). Statistical analyses were performed using SPSS software version 19.0, SNPStats, GMDR software (version 6) and GENEMANIA.ResultsLogistic regression analysis of 55 SNPs revealed significant associations (P < .05) of 49 SNPs with BMI linked obesity risk whereas the remaining 6 SNPs revealed no association (P > .05). The pathway‐wise G‐score revealed the significant role (P = .0001) of food intake‐energy expenditure pathway genes. In CART analysis, the combined genotypes of FTO rs9939609 and TCF7L2 rs7903146 revealed the highest risk for BMI linked obesity. The analysis of the FTO‐IRX3 locus revealed high LD and high order gene‐gene interactions for BMI linked obesity. The interaction network of all of the associated genes in the present study generated by GENEMANIA revealed direct and indirect connections. In addition, the analysis with centralized obesity revealed that none of the SNPs except for FTO rs17818902 were significantly associated (P < .05).ConclusionsIn this multi‐analytical approach, FTO rs9939609 and IRX3 rs3751723, along with TCF7L2 rs7903146 and TMEM18 rs6548238, emerged as the major SNPs contributing to BMI linked obesity risk in the North Indian population.
The turbinal flap: an additional option for anterior skull base reconstruction. Cadaveric feasibility study and case report
Authors: Schreiber Alberto , Mattavelli Davide , Ferrari Marco , Rampinelli Vittorio , Lancini Davide , Belotti Francesco , Rodella Luigi Fabrizio , Nicolai Piero 
Published: September 2016

BackgroundOver the past decade, the treatment of complex intradural and extradural pathologies via expanded endonasal approaches has been made possible by progresses and refinements in skull base reconstruction techniques. The aim of this anatomic study is to describe a novel endonasal flap, the turbinal flap (TF), based on the middle and superior turbinate mucosa and pedicled on the ethmoidal arteries system.MethodsThree fresh‐frozen (6 sides) cadaver heads previously injected with colored silicone were dissected. A step‐by‐step description of the surgical technique is provided. Vascularization of the TF and its range of possibilities to cover anterior skull base defects were studied. Flap dimensions and area were measured. A case report where the TF was successfully used is also described.ResultsThe TF was adequate to repair defects along the entire ethmoid roof. Its pedicle along the skull base was 3.0 cm in length and sagittally oriented. Mean measures of the TF were 3.4 cm (anterior height), 5.5 cm (posterior height), and 4.8 cm (inferior length). Its mean area was 8.6 cm2. The flap was supplied by rich network of vessels. A demonstrative case of anterior skull base repair after the endoscopic resection of meningocephalocele of the ethmoid roof is reported.ConclusionThe main indication for the TF is the repair of anterior skull base defects involving the ethmoid roof. Its advantages include the double pedicle, rich vascularization, autonomy from the maxillary artery system, and preservation of the olfactory mucosa.
Sterisch anspruchsvolle 2,6‐disubstituierte Aniline durch direkte C‐N‐Bindungsknüpfung an Iod(III)‐Zentren
Authors: Lucchetti Nicola , Scalone Michelangelo , Fantasia Serena , Muñiz Kilian 
Published: September 2016

Abstract2,6‐Disubstitutierte Aniline werden bequem durch eine direkte Reaktion zwischen Amiden und Diaryliodonium‐Salzen synthetisiert. Wie anhand von 24 unterschiedlichen Beispielen gezeigt wird, weist die Reaktion eine ungewöhnlich große Substratbreite bezüglich der sterisch anspruchsvollen Aren‐ und der Stickstoffgruppierung auf, benötigt keinen weiteren Promotor und verläuft über eine direkte reduktive Eliminierung am Iod(III)‐Zentrum. Die Effizienz dieses Kupplungsprotokolls wird zudem anhand der kurzen Synthese eines Chemerin‐Bindungsinhibitors demonstriert.
Independent Control of Elastomer Properties through Stereocontrolled Synthesis
Authors: Bell Craig A. , Yu Jiayi , Barker Ian A. , Truong Vinh X. , Cao Zhen , Dobrinyin Andrey V. , Becker Matthew L. , Dove Andrew P. 
Published: September 2016

AbstractIn most synthetic elastomers, changing the physical properties by monomer choice also results in a change to the crystallinity of the material, which manifests through alteration of its mechanical performance. Using organocatalyzed stereospecific additions of thiols to activated alkynes, high‐molar‐mass elastomers were isolated via step‐growth polymerization. The resulting controllable double‐bond stereochemistry defines the crystallinity and the concomitant mechanical properties as well as enabling the synthesis of materials that retain their excellent mechanical properties through changing monomer composition. Using this approach to elastomer synthesis, further end group modification and toughening through vulcanization strategies are also possible. The organocatalytic control of stereochemistry opens the realm to a new and easily scalable class of elastomers that will have unique chemical handles for functionalization and post synthetic processing.
Self‐Organized Stationary Patterns in Networks of Bistable Chemical Reactions
Authors: Kouvaris Nikos E. , Sebek Michael , Mikhailov Alexander S. , Kiss István Z. 
Published: September 2016

AbstractExperiments with networks of discrete reactive bistable electrochemical elements organized in regular and nonregular tree networks are presented to confirm an alternative to the Turing mechanism for the formation of self‐organized stationary patterns. The results show that the pattern formation can be described by the identification of domains that can be activated individually or in combinations. The method also enabled the localization of chemical reactions to network substructures and the identification of critical sites whose activation results in complete activation of the system. Although the experiments were performed with a specific nickel electrodissolution system, they reproduced all the salient dynamic behavior of a general network model with a single nonlinearity parameter. Thus, the considered pattern‐formation mechanism is very robust, and similar behavior can be expected in other natural or engineered networked systems that exhibit, at least locally, a treelike structure.
Oxidation State Dependent Coordination Modes: Accessing an Amidate‐Supported Nickel(I) δ‐bis(C−H) Agostic Complex
Authors: Beattie D. Dawson , Bowes Eric G. , Drover Marcus W. , Love Jennifer A. , Schafer Laurel L. 
Published: September 2016

AbstractAmidate‐supported two‐ and three‐coordinate NiI complexes were synthesized by reduction of the corresponding NiII precursors. A dramatic change in binding mode is observed upon reduction from NiII to NiI. The NiI derivatives include an unprecedented NiI bis(C−H) agostic complex and a two‐coordinate NiI complex.
Oxidative Cleavage of C=S and P=S Bonds at an AlI Center: Preparation of Terminally Bound Aluminum Sulfides
Authors: Chu Terry , Vyboishchikov Sergei F. , Gabidullin Bulat , Nikonov Georgii I. 
Published: September 2016

AbstractThe treatment of cyclic thioureas with the aluminum(I) compound NacNacAl (1; NacNac=[ArNC(Me)CHC(Me)NAr]−, Ar=2,6‐Pri2C6H3) resulted in oxidative cleavage of the C=S bond and the formation of 3 and 5, the first monomeric aluminum complexes with an Al=S double bond stabilized by N‐heterocyclic carbenes. Compound 1 also reacted with triphenylphosphine sulfide in a similar manner, which resulted in cleavage of the P=S bond and production of the adduct [NacNacAl=S(S=PPh3)] (8). The Al=S double bond in 3 can react with phenyl isothiocyanate to furnish the cycloaddition product 9 and zwitterion 10 as a result of coupling between the liberated carbene and PhN=C=S. All novel complexes were characterized by multinuclear NMR spectroscopy, and the structures of 5, 9, and 10 were confirmed by X‐ray diffraction analysis. The nature of the Al=S bond in 5 was also probed by DFT calculations.
Self‐Assembly of Amphiphilic Drug–Dye Conjugates into Nanoparticles for Imaging and Chemotherapy
Authors: Sun Tingting , Lin Wenhai , Zhang Wei , Xie Zhigang 
Published: September 2016

AbstractAn amphiphilic drug–dye conjugate (PTX‐Pt‐BDP) was designed and synthesized with a platinum compound as the hydrophilic head. The precursor of PTX‐Pt‐BDP was obtained under mild conditions by means of a three‐component Passerini reaction. PTX‐Pt‐BDP could self‐assemble into nanoparticles (PTX‐Pt‐BDP NPs) in aqueous solution via a nanoprecipitation method. The obtained nanoparticles exhibited favorable structural stability in both water and physiological environment. PTX‐Pt‐BDP NPs could be endocytosed by cancer cells as revealed by confocal laser scanning microscopy and exert potent cytotoxicity. This work highlights the potential of nanomedicines from amphiphilic drug–dye conjugates for cancer cell imaging and chemotherapy.
Techno‐economic assessment of biorefinery technologies for aviation biofuels supply chains in Brazil
Authors: Alves Catarina M. , Valk Misha , de Jong Sierk , Bonomi Antonio , van der Wielen Luuk A.M. , Mussatto Solange I. 
Published: September 2016

AbstractProduction of aviation biofuels has been strongly encouraged by the volatility of oil prices and environmental concerns. Brazilian society, companies, and government are taking a step forward in the production of renewable jet fuel from biomass feedstocks largely available in the territory. This study evaluated the use of different feedstocks (sugar crops, oil crops, and lignocellulosic biomass) for co‐production of biojet fuel and higher value‐added products in a biorefinery platform. The co‐production of biofuels and biochemicals in a biorefinery context was demonstrated to be economically feasible. The main cost drivers of such a platform are feedstock biomass cost, selling price of the biochemicals, investment costs, and key process‐inherent parameters such as conversion yields, obtained fermentable sugars, or oil content in the feedstock. Sugarcane was the most promising feedstock for a biorefinery in the region of Minas Gerais, while soybean was the most promising feedstock for a biorefinery in the region of Rio Grande do Sul, despite its higher uncertainty. Succinic acid was the most promising chemical intermediate for biopolymers industry due to its relatively high market value, unique market opportunity as a substitute of conventional petrochemicals, and forecast for future growth. Ethanol‐to‐jet (ETJ) and hydro‐processed esters and fatty acids (HEFA) were the most attractive biojet fuel production routes in the present study. Scenarios for co‐production of biofuels and biochemicals in Brazil present large uncertainties and high financial risk, mainly due to the use of second‐generation feedstocks, and the introduction of new technologies and products. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd
Integration of growth factor gene delivery with collagen‐triggered wound repair cascades using collagen‐mimetic peptides
Authors: Urello Morgan A. , Kiick Kristi L. , Sullivan Millicent O. 
Published: September 2016

AbstractGrowth factors (GFs) play vital roles in wound repair. Many GF therapies have reached clinical trials, but success has been hindered by safety concerns and a lack of efficacy. Previously, we presented an approach to produce protein factors in wound beds through localized gene delivery mediated by biomimetic peptides. Modification of polyethylenimine (PEI) DNA polyplexes with collagen‐mimetic peptides (CMPs) enabled tailoring of polyplex release/retention and improved gene transfer activity in a cell‐responsive manner. In this work, CMP‐mediated delivery from collagen was shown to improve expression of platelet‐derived growth factor–BB (PDGF‐BB) and promote a diverse range of cellular processes associated with wound healing, including proliferation, extracellular matrix production, and chemotaxis. Collagens were pre‐exposed to physiologically‐simulating conditions (complete media, 37°C) for days to weeks prior to cell seeding to simulate the environment within typical wound dressings. In cell proliferation studies, significant increases in cell counts were demonstrated in collagen gels containing CMP‐modified polyplex versus unmodified polyplex, and these effects became most pronounced following prolonged preincubation periods of greater than a week. Collagen containing CMP‐modified polyplexes also induced a twofold increase in gel contraction as well as enhanced directionality and migratory activity in response to cell‐secreted PDGF‐BB gradients. While these PDGF‐BB‐triggered behaviors were observed in collagens containing unmodified polyplexes, the responses withstood much longer preincubation periods in CMP‐modified polyplex samples (10 days vs. <5 days). Furthermore, enhanced closure rates in an in vitro wound model suggested that CMP‐based PDGF‐BB delivery may have utility in actual wound repair and other regenerative medicine applications.
Folate receptor‐targeted aminoglycoside‐derived polymers for transgene expression in cancer cells
Authors: Godeshala Sudhakar , Nitiyanandan Rajeshwar , Thompson Brian , Goklany Sheba , Nielsen David R. , Rege Kaushal 
Published: September 2016

AbstractTargeted delivery of anticancer therapeutics can potentially overcome the limitations associated with current chemotherapeutic regimens. Folate receptors are overexpressed in several cancers, including ovarian, triple‐negative breast and bladder cancers, making them attractive for targeted delivery of nucleic acid therapeutics to these tumors. This work describes the synthesis, characterization and evaluation of folic acid‐conjugated, aminoglycoside‐derived polymers for targeted delivery of transgenes to breast and bladder cancer cell lines. Transgene expression was significantly higher with FA‐conjugated aminoglycoside‐derived polymers than with Lipofectamine, and these polymers demonstrated minimal cytotoxicty. Competitive inhibition using free folic acid significantly reduced transgene expression efficacy of folate‐targeted polymers, suggesting a role for folate receptor‐mediated uptake. High efficacy FA‐targeted polymers were employed to deliver a plasmid expressing the TRAIL protein, which induced death in cancer cells. These results indicate that FA‐conjugated aminoglycoside‐derived polymers are promising for targeted delivery of nucleic acids to cancer cells that overexpress folate receptors.
Comparative Case–Control analysis of a dedicated self‐expanding Biolimus A9‐eluting Bifurcation stent versus provisional or mandatory side branch intervention strategies in the treatment of coronary bifurcation lesions
Authors: Ohlow Marc‐Alexander , Farah Ahmed , Richter Stefan , El‐Garhy Mohamad , von Korn Hubertus , Lauer Bernward 
Published: September 2016

BackgroundIn a number of coronary bifurcation lesions, both the main vessel and the side branch (SB) need stent coverage.ObjectivesTo analyze the procedural performance and the impact on radiation times (RT) and contrast medium consumption (CMC) of the Axxess™ stent system (Biosensors, Switzerland) treating de novo bifurcation lesions (DBL).MethodsOne hundred and ten consecutive prospectively enrolled cases (Axxess Group) and 110 age, sex, and lesion location matched controls undergoing mandatory (Group A, n = 56) or provisional (Group B, n = 54) SB intervention were analyzed.ResultsAlthough more pre‐dilatation was performed in the Axxess Group (92.7% vs. 46.4% [Group A] vs. 24.1% [Group B]), and more stents were used (2.4 vs. 1.2 vs. 1.05), RT and CMC were significantly lower in the Axxess Group [7.9 min/129 ml vs. 14.2 min/209 ml vs. 7.8 min/152 ml; P < 0.001]. Final Thrombolysis In Myocardial Infarction three flow in both branches was significantly more frequent in the Axxess Group (98.2% vs. 94.6% vs. 88.9%; P = 0.02), and post‐interventional troponin T elevations were the lowest in the Axxess Group. Eighty one percent of the Axxess‐stents could be implanted without technical difficulties. Difficult implantations procedures were mainly related to coronary anatomy. There was no safety concerns (cardiac death, stent‐thrombosis) compared to controls. Cumulative 6‐months MACE rates were 11% versus 23% versus 25%. TLR rates at 6‐months were 5%, 18%, and 15%, respectively.ConclusionsAxxess bifurcation stent system procedures were associated with significantly less RT and CMC compared to conventional DBL therapy strategies. Difficult coronary anatomy may hinder successful implantation and a learning curve has to be considered. © 2016 Wiley Periodicals, Inc.
Copper(II)‐Catalyzed Direct Azidation of N‐Acylated 8‐Aminoquinolines by Remote C−H Activation
Authors: Dou Yandong , Xie Zhenda , Sun Zongguo , Fang Hongli , Shen Chao , Zhang Pengfei , Zhu Qing 
Published: September 2016

AbstractA simple and efficient copper(II)‐catalyzed C5 azidation of N‐acylated 8‐aminoquinolines by remote C−H activation was developed. On the basis of this reaction, a series of new C5‐azidated 8‐amidequinolines were synthesized in moderate to good yields.