bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental versus non‐parental–directed donation: an 11‐year experience of infectious disease testing at a pediatric tertiary care blood donor center
Authors: Jacquot Cyril , Seo Andrew , Miller Peter M. , Lezama Niara , Criss Valli R. , Colvin Camilla , Luban Naomi L.C. , Wong Edward C.C. 
Published: September 2017

BACKGROUNDDirected donation is associated with a higher prevalence of donations that are positive for infectious disease markers; however, little is known about the positive rates among parental‐directed, non‐parental–directed, and allogeneic donations.STUDY DESIGN AND METHODSWe reviewed blood‐collection records from January 1997 through December 2008, including infectious disease results, among parental, non‐parental, and community donations. Infectious disease rates were compared by Mann‐Whitney U test.RESULTSIn total, 1532 parental, 4910 non‐parental, and 17,423 community donations were examined. Among parental donors, the median rate of positive infectious disease testing was 8.66% (interquartile range (IQR), 4.49%) for first‐time donors and 1.26% (IQR, 5.86%) for repeat donors; among non‐parental donors, the rate was 1.09% (IQR, 0.98%) for first‐time donors and 0% (IQR, 0.83%) for repeat donors; and, among community donors, the rate was 2.95% (IQR, 1.50%) for first‐time donors and 0.45% (IQR, 0.82%) for repeat donors. The mean rate of positive infectious disease testing for first‐time parental donors was significantly higher (7.63%), whereas all repeat donors had similar rates. However, the rate of positive infectious disease testing among first‐time non‐parental donors was significantly lower than that in the other groups, especially for the period from 2001 through 2008.CONCLUSIONFirst‐time non‐parental and community donors had significantly higher infectious disease risk than the respective repeat donors. First‐time parental donors had the highest rates of positive infectious disease testing. We suggest that first‐time parental blood donation should be discouraged. Repeat community donors or first‐time non‐parental donors provide a safer alternative. These findings can foster better patient education, donor selection, and possibly a reduced risk of infectious disease.
Second‐look arthroscopic findings after CORA‐based leveling osteotomy
Authors: Vasquez Barbara , Hulse Don , Beale Brian , Kerwin Sharon , Andrews Chad , Saunders Brian W. 
Published: September 2017

AbstractObjectiveTo describe the arthroscopic appearance of intra‐articular structures mid‐term (9 months) and long‐term (>12 months) after CORA‐based leveling osteotomy (CBLO).Study designCase series.AnimalsDogs (n = 41) with second‐look arthroscopy of the stifle after CBLO for treatment of a cranial cruciate ligament (CCL) deficiency. Both stifles were re‐evaluated (stifles n = 42) in 1 dog.MethodsMedical records of dogs that had second‐look arthroscopy after CBLO were reviewed. Arthroscopic images of the femoral condyles were independently reviewed. The surgical report documented the integrity of menisci and articular cartilage of the tibial plateaus.ResultsThe population included 7 stifles with stable partial CCL tears, 35 stifles with complete CCL tears (n = 28), or incompetent partial CCL tears (n = 7). Median time to second look arthroscopy was 16 months (9‐24 months) for stable partial tears. The CCL remained intact in 6 stifles. The Outerbridge score of the articular cartilage of the femoral condyles was as 0 (6) or 1 (1). The articular cartilage of the tibial plateaus appeared normal in all stifles. Median time to second look arthroscopy of stifles with complete tears was 12 months (range, 9‐34 months). The caudal cruciate ligament was normal or mildly fibrillated. The appearance of the articular cartilage of the femoral condyles was scored as 0 or near normal (grade 1‐2) in all dogs. The articular cartilage of the tibial plateaus appeared normal, except in 1 dog with grade 4 lesion.ConclusionCBLO results in minimal to no change in articular cartilage in at a median time of 14 months after surgery. Postoperative clinical lameness is often attributed to late onset meniscal pathology.
La música de Rainer Viertlböck en la versión restaurada del film Das Kabinett des Doktor Caligari de Robert Wiene (1919)
Authors: Amorós Pons Anna María , Gómez Otero Nuria 
Published: September 2017

En el artículo se resumen los resultados más destacables de un estudio integrado en una investigación más general sobre la música como elemento narrativo en el Cine de la República de Weimar. Esta aportación se ha acotado al estudio musical de la película considerada obra maestra del expresionismo cinematográfico alemán, Das Kabinett des Doktor Caligari de Robert Wiene (1919). El texto se adentra en el complejo estudio de la composición musical realizada en este caso por Rainer Viertlböck en 1993, para la versión íntegra restaurada y basada en la reconstrucción del coloreado del film. Metodológicamente se opta por un estudio de caso histórico-descriptivo, analítico-cualitativo y hermenéutico. A través de un minucioso análisis músico-fílmico de las escenas se pone de manifiesto los elementos estructurales presentes, los recursos estilísticos y estéticos utilizados, las corrientes y tendencias que emanan, así como los instrumentos empleados en la composición musical para dicho film.
Pedagogía popular a partir de prácticas artísticas marginales realizadas con objetos de lo cotidiano
Authors: García Camargo Dimo Leonardo 
Published: September 2017

Este texto examina algunas prácticas artísticas marginales, que pueden entenderse como generadoras de un enriquecimiento disidente y de un bienestar social divergente frente a las lógicas economicistas que imperan en el mundo contemporáneo.En este artículo vamos a estudiar algunas características del arte marginal (outsider art) realizado con objetos de lo cotidiano, con el fin de elaborar algunas orientaciones metodológicas, a partir de dichas características, para una pedagogía popular que permita un trabajo de exploración artística y de emancipación social.
Draft Genome Sequence of a Pseudomonas aeruginosa NA04 Bacterium Isolated from an Entomopathogenic Nematode
Authors: Salgado-Morales Rosalba , Rivera-Gómez Nancy , Lozano-Aguirre Beltrán Luis Fernando , Hernández-Mendoza Armando , Dantán-González Edgar 
Published: September 2017

ABSTRACT

We report the draft genome sequence of Gram-negative bacterium
Pseudomonas aeruginosa
NA04, isolated from the entomopathogenic nematode
Heterorhabditis indica
MOR03. The draft genome consists of 54 contigs, a length of 6.37 Mb, and a G+C content 66.49%.
Draft Genome Sequences of Listeria monocytogenes Strains from Listeriosis Outbreaks Linked to Soft Cheese in Washington State
Authors: Li Zhen , Marsland Paula A. , Meek Roxanne T. , Eckmann Kaye , Allard Marc W. , Pérez-Osorio Ailyn C. 
Published: September 2017

ABSTRACT

Listeria monocytogenes
has caused listeriosis outbreaks linked to soft cheese. Here, we report the draft genome sequences of seven
L. monocytogenes
isolates from two possibly related outbreaks caused by soft cheese products in Washington State.
The effect of paid maternity leave on early childhood growth in low-income and middle-income countries
Authors: Jahagirdar Deepa , Harper Sam , Heymann Jody , Swaminathan Hema , Mukherji Arnab , Nandi Arijit 
Published: September 2017

BackgroundDespite recent improvements, low height-for-age, a key indicator of inadequate child nutrition, is an ongoing public health issue in low-income and middle-income countries. Paid maternity leave has the potential to improve child nutrition, but few studies have estimated its impact.MethodsWe used data from 583 227 children younger than 5 years in 37 countries surveyed as part of the Demographic and Health Surveys (2000–2014) to compare the change in children’s height-for-age z score in five countries that increased their legislated duration of paid maternity leave (Uganda, Zambia, Zimbabwe, Bangladesh and Lesotho) relative to 32 other countries that did not. A quasiexperimental difference-in-difference design involving a linear regression of height-for-age z score on the number of weeks of legislated paid maternity leave was used. We included fixed effects for country and birth year to control for, respectively, fixed country characteristics and shared trends in height-for-age, and adjusted for time-varying covariates such as gross domestic product per capita and the female labour force participation rate.ResultsThe mean height-for-age z scores in the pretreatment period were -1.91 (SD=1.44) and –1.47 (SD=1.57) in countries that did and did not change their policies, respectively. The scores increased in treated and control countries over time. A 1-month increase in legislated paid maternity leave was associated with a decrease of 0.08(95% CI −0.20 to 0.04) in child height-for-age z score. Sensitivity analyses did not support a robust association between paid maternity leave policies and height-for-age z score.ConclusionWe found little evidence that recent changes in legislated paid maternity leave have been sufficient to affect child height-for-age z scores. The relatively short durations of leave, the potential for low coverage and the strong increasing trend in children’s growth may explain our findings. Future studies considering longer durations or combined interventions may reveal further insight to support policy.
Hearing threshold shifts among military pilots of the Israeli Air Force
Authors: Kampel-Furman Liyona , Joachims Z , Bar-Cohen H , Grossman A , Frenkel-Nir Y , Shapira Y , Alon E , Carmon E , Gordon B 
Published: September 2017

BackgroundMilitary aviators are potentially at risk for developing noise-induced hearing loss. Whether ambient aircraft noise exposure causes hearing deficit beyond the changes attributed to natural ageing is debated. The aim of this research was to assess changes in hearing thresholds of Israeli Air Force (IAF) pilots over 20 years of military service and identify potential risk factors for hearing loss.MethodsA retrospective cohort analysis was conducted of pure-tone air conduction audiograms of pilots, from their recruitment at 18 years of age until the last documented medical check-up. Mean hearing thresholds were analysed in relation to age, total flight hours and aircraft platform. Comparisons were made to the hearing thresholds of air traffic controllers (ATCs) who were not exposed to the noise generated by aircraft while on duty.ResultsOne hundred and sixty-three pilots were included, with flying platforms ranging from fighter jets (n=54), combat helicopters (n=27), transport helicopters (n=52) and transport aircraft (n=30). These were compared with the results from 17 ATCs. A marked notch in the frequency range of 4–6 kHz was demonstrated in the mean audiograms of all platforms pilots, progressing with ageing. Hearing threshold shifts in relation to measurements at recruitment were first noted at the age of 30 years, particularly at 4 kHz (mean shift of 2.97 dB, p=0.001). There was no statistical association between flying variables and hearing thresholds adjusted for age by logistic regression analysis.ConclusionsThe audiometric profile of IAF pilots has a pattern compatible with noise exposure, as reflected by characteristic noise notch. However, no flight variable was associated with deterioration of hearing thresholds, and no significant difference from non-flying controls (ATCs) was seen.
Breath-to-breath variability of exhaled CO2 as a marker of lung dysmaturity in infancy
Authors: Fouzas Sotirios , Theodorakopoulos Ilias , Delgado-Eckert Edgar , Latzin Philipp , Frey Urs 
Published: September 2017

The concept of diffusional screening implies that breath-to-breath variations in CO2 clearance, when related to the variability of breathing, may contain information on the quality and utilization of the available alveolar surface. We explored the validity of the above hypothesis in a cohort of young infants of comparable postmenstrual age but born at different stages of lung maturity, namely, in term-born infants ( n = 128), preterm-born infants without chronic lung disease of infancy (CLDI; n = 53), and preterm infants with moderate/severe CLDI ( n = 87). Exhaled CO2 volume (VE,CO2) and concentration (FE,CO2) were determined by volumetric capnography, whereas their variance was assessed by linear and nonlinear variability metrics. The relationship between relative breath-to-breath change of VE,CO2 (ΔVE,CO2) and the corresponding change of tidal volume (ΔVT) was also analyzed. Nonlinear FE,CO2 variability was lower in CLDI compared with term and non-CLDI preterm group ( P < 0.001 for both comparisons). In CLDI infants, most of the VE,CO2 variability was attributed to the variability of VT ( r2 = 0.749), whereas in term and healthy preterm infants this relationship was weaker ( r2 = 0.507 and 0.630, respectively). The ΔVE,CO2 − ΔVT slope was less steep in the CLDI group (1.06 ± 0.07) compared with non-CLDI preterm (1.16 ± 0.07; P < 0.001) and term infants (1.20 ± 0.10; P < 0.001), suggesting that the more dysmature the infant lung, the less efficiently it eliminates CO2 under tidal breathing conditions. We conclude that the temporal variation of CO2 clearance may be related to the degree of lung dysmaturity in early infancy. NEW & NOTEWORTHY Young infants exhibit appreciable breath-to-breath CO2 variability that can be quantified by nonlinear variability metrics and may reflect the degree of lung dysmaturity. In infants with moderate/severe chronic lung disease of infancy (CLDI), the variability of the exhaled CO2 is mainly driven by the variability of breathing, whereas in term-born and healthy preterm infants this relationship is less strong. The slope of the relative CO2-to-volume change is less steep in CLDI infants, suggesting that dysmature lungs are less efficient in eliminating CO2 under tidal breathing conditions.
Modeling Major Adverse Outcomes of Pediatric and Adult Patients With Congenital Heart Disease Undergoing Cardiac Catheterization
Authors: Jayaram Natalie , Spertus John A. , Kennedy Kevin F. , Vincent Robert , Martin Gerard R. , Curtis Jeptha P. , Nykanen David , Moore Phillip M. , Bergersen Lisa 
Published: September 2017

Background:
Risk standardization for adverse events after congenital cardiac catheterization is needed to equitably compare patient outcomes among different hospitals as a foundation for quality improvement. The goal of this project was to develop a risk-standardization methodology to adjust for patient characteristics when comparing major adverse outcomes in the NCDR’s (National Cardiovascular Data Registry) IMPACT Registry (Improving Pediatric and Adult Congenital Treatment).

Methods:
Between January 2011 and March 2014, 39 725 consecutive patients within IMPACT undergoing cardiac catheterization were identified. Given the heterogeneity of interventional procedures for congenital heart disease, new procedure-type risk categories were derived with empirical data and expert opinion, as were markers of hemodynamic vulnerability. A multivariable hierarchical logistic regression model to identify patient and procedural characteristics predictive of a major adverse event or death after cardiac catheterization was derived in 70% of the cohort and validated in the remaining 30%.

Results:

The rate of major adverse event or death was 7.1% and 7.2% in the derivation and validation cohorts, respectively. Six procedure-type risk categories and 6 independent indicators of hemodynamic vulnerability were identified. The final risk adjustment model included procedure-type risk category, number of hemodynamic vulnerability indicators, renal insufficiency, single-ventricle physiology, and coagulation disorder. The model had good discrimination, with a C-statistic of 0.76 and 0.75 in the derivation and validation cohorts, respectively. Model calibration in the validation cohort was excellent, with a slope of 0.97 (standard error, 0.04;
P
value [for difference from 1] =0.53) and an intercept of 0.007 (standard error, 0.12;
P
value [for difference from 0] =0.95).

Conclusions:
The creation of a validated risk-standardization model for adverse outcomes after congenital cardiac catheterization can support reporting of risk-adjusted outcomes in the IMPACT Registry as a foundation for quality improvement.
High Levels of (Un)Switched Memory B Cells Are Associated With Better Outcome in Patients With Advanced Atherosclerotic Disease
Authors: Meeuwsen John A. L. , van Duijvenvoorde Amerik , Gohar Aisha , Kozma Maria O. , van de Weg Sander M. , Gijsberts Crystel M. , Haitjema Saskia , Björkbacka Harry , Fredrikson Gunilla N. , de Borst Gert J. , den Ruijter Hester M. , Pasterkamp Gerard , Binder Christoph J. , Hoefer Imo E. , de Jager Saskia C. A. 
Published: September 2017

Background
Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B‐cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating B‐cell subtypes with the occurrence of secondary cardiovascular events in advanced atherosclerotic disease.

Methods and Results

This cohort study consists of 168 patients who were included in the Athero‐Express biobank between 2009 and 2011. Before surgery, peripheral blood mononuclear cells were isolated and stored in liquid nitrogen. After gentle thawing of the peripheral blood mononuclear cells, different B‐cell subtypes including naïve, (un)switched memory, and
CD
27
+
CD
43
+
B1‐like B cells, were analyzed by flow cytometry. Univariable and multivariable Cox proportional hazard models were used to analyze associations between B‐cell subtypes, circulating antibodies and secondary cardiovascular manifestations during the 3‐year follow‐up period. Mean age was 70.1±9.6 years, males represented 62.8% of the population, and 54 patients had secondary manifestations during follow‐up. High numbers of unswitched memory cells were protective against secondary outcome (hazard ratio, 0.30 [95%
CI
, 0.13–0.69];
P
<0.01). Similar results were obtained for the switched memory cells that also showed to be protective against secondary outcome (hazard ratio, 0.33 [95%
CI
, 0.14–0.77];
P
=0.01).

Conclusions
A high number of (un)switched memory B cells is associated with better outcome following carotid artery endarterectomy. These findings suggest a potential role for B‐cell subsets in prediction and prevention of secondary cardiovascular events in patients with atherosclerosis.
Predicting the cation exchange capacity of reservoir rocks from complex dielectric permittivity measurements
Authors: Garrouch Ali A. 
Published: September 2017

Dimensional analysis was performed to understand the physics of ionic dispersion in reservoir rocks and to identify the factors influencing the cation exchange capacity (CEC) of these rocks. Dimensional analysis revealed the existence of a general relation independent of the unit system between two dimensionless groups denoted as the cationic dispersion number [Formula: see text] and the conductivity number [Formula: see text]. The former group [Formula: see text] stands for the ratio of the CEC to the electrical double-layer dispersion. The latter group [Formula: see text] represents the ratio of the low-frequency ionic conductivity to the high-frequency electronic polarization. Complex dielectric permittivity measurements on 121 water-saturated sandstone and carbonate rock samples were used to validate the dimensionless groups. In retrospect, dimensional analysis was useful in identifying variables influencing the CEC of hydrocarbon rocks. In particular, these variables consist of rock porosity [Formula: see text], specific surface area, and five other parameters of the Cole-Cole function, which describes the frequency dependence of the complex permittivity of rock samples in the range 10–1300 MHz. The Cole-Cole function parameters are [Formula: see text], which is a characteristic relaxation time; [Formula: see text] is the so-called spread parameter; [Formula: see text] is the real DC conductivity of water-saturated rocks; and [Formula: see text] and [Formula: see text], which are the real numbers representing the static and the high-frequency dielectric permittivities of the water-saturated rock, respectively. A general regression neural network (GRNN) model was developed to predict the CEC of shaly sandstones and carbonate rocks as a function of the variables identified by the dimensional analysis as essential in predicting the CEC. The CEC prediction capability of the GRNN model has been tested with a blind data set, and it has been compared with the CEC prediction capability using a nonlinear regression model developed in this study and using a linear regression model available in the literature. The GRNN model outperformed both of these empirical models. With the GRNN model, it is possible to obtain reliable quantitative estimates of the CEC of shaly sandstone and carbonate rocks using nondestructive frequency-dependent dielectric permittivity measurements that are rapid, economic, and accurate. In return, accurate and fast estimates of the CEC are useful in many petroleum engineering applications. They can be used to identify clay types and can also be used to quantify the volume of hydrocarbon in shaly sands using well-log resistivity data. The results of this study represent a major advantage for formation evaluation, wellbore stability analysis, and designing stimulation jobs.
Infusion Room–Based Transition to Practice Model for Teaching Cancer Systemic Therapy Management
Authors: Duff Jennifer M. , Markham Merry-Jennifer , George Thomas J. , Close Julia L. 
Published: September 2017

Purpose: Oncology training requirements mandate that fellows demonstrate competence in delivery of cancer therapeutics, understand clinical indications for treatment, and manage toxicities by completion of training. An academic training environment may hinder fellows’ engagement in prescribing, monitoring, and adjusting cancer therapy; thus, trainees may complete their fellowship with limited experience in developing such critical skills. To provide hands-on experience in cancer systemic therapy management, we created a novel infusion room–based rotation in the final year of training; here we report the structure, logistics, and evaluation of this innovative program. Methods: In 2004, The University of Florida Hematology Oncology Fellowship Program created an outpatient infusion room rotation called Transition to Practice (TTP). We surveyed 20 graduates of the program to assess the ability of the rotation to teach skills necessary for systemic therapy management and identify which fellowship rotations had an impact on their readiness to practice independently. Results: Nineteen graduates completed the survey. TTP was rated highest for promoting independence in making decisions related to therapy and adjustment to the treatment plan. It was less valuable in teaching the financial aspects of cancer therapy encounters. The Veterans Affairs Medical Center continuity clinic and the TTP rotation were highly regarded for preparing graduates to practice oncology independently. Conclusion: We consider the TTP model an effective learning environment for oncology trainees to develop the essential skill set for managing cancer systemic therapy on the basis of this single-institution analysis of recent graduates. This model could be applied to training other oncology professionals, such as advanced practice providers, who are new to the field.