bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supraventricular bradycardia following heart transplantation necessitating pacemaker implantation – An analysis of possible underlying causes
Authors: Schmid Christof , Wahlers Thorsten , Jurmann Michael , Cremer Jochen , Fieguth Hans‐Gerd , Schäfers Hans‐Joachim , Haverich Axel 
Published: September 2024

Underlying causes for the development of supraventricular bradycardias following heart transplantation are still controversial. A retrospective study investigating preoperative antiarrhythmic drug treatment of the recipient, donor age, ischemic time and surgical complications as possible underlying causes was therefore conducted. From January 1987 through December 1990, 224 orthotopic heart transplantations were performed. After exclusion of redo‐procedures and early deaths, 171 patients (148 male, 23 female; 9 to 62 years, mean 44± 12 yr) were included. While 34 patients showed a supraventricular bradycardia during the early postoperative period (≤14 days), (incidence of 19.9%/Group I), 137 patients demonstrated normal signs rhythm (Group II). All patients in Group I underwent VVI‐pacemaker implantation after a median time interval of 18 d after the initial operation. By Chi‐square‐test analysis, a significant higher cumulative amount of pretransplant antiarrhythmic drug treatment was found in Group I (p< 0.005). However, subsequent multivariant analysis only identified amiodarone to be of significant influence on postoperative pacemaker requirement (ANOVA/Fisher PLSD, 95% confidence level). In contrast, no significant correlation was found with regard to donor age (Group I vs. Group II: 28.1 ± 18.4 yr vs. 26.8± 17.5 yr), ischemic lime (151 ±45 min vs. 149±35 min) and surgical technique. After a follow‐up period of 6 and 12 months, 16 (9.4%) and 15 patients (8.8%) of Group I, respectively, presented ongoing pacemaker demand, whereas 18 and 19 patients, respectively, regained sufficient supraventricular rhythm. In 2 patients surgical reintervention for lead dislocation after endomyocardial biopsy was necessary. It is concluded that about 20% of patients will develop a supraventricular bradycardia after orthotopic heart transplantation that will require a pacemaker. The underlying causes may involve various mechanisms; however, based on our results, only the cumulative amount of preoperative antiarrhythmic drug treatment or amiodarone alone were found to be of significance. Sinoatrial function recovers spontaneously in 50% of the patients within 6 months postoperatively.
An economic analysis of pancreas transplantation: Costs, insurance coverage, and reimbursement
Authors: Evans Roger W. , Manninen Diane L. , Dong Frederick B. 
Published: September 2024

Since 1988 the demand for the pancreas transplantation has continued to increase. This has been accompanied by a growth in the number of centers offering the procedure, and an increase in the number of transplants performed. The National Cooperative Transplantation Study was undertaken to document the costs of all transplants, including pancreas transplantation. Data on transplantation procedure charges, from date of transplant to discharge, were obtained from 66.7% of all pancreas transplantation programs active in 1988. These programs accounted for 72% of all transplants performed that year. Valid sample survey data (no more than 25 transplants per center) were obtained for 133 randomly selected patients. This constituted 54% of all procedures done in the United States in 1988. Detailed data were also collected on sources of payment and amount reimbursed. Due to outlier data, we report statistical medians, rather than means, as our measure of central tendency. The median charge for a pancreas transplant with or without a kidney was $66 917, with a hospital length of stay of 21 days, compared with a kidney transplant alone at $39 625 and a hospital length of stay of 14 days. Total pancreas transplant charges fell between $45 260 and $105 375 for 50% of the cases studied. Half of the patients had a hospital length of stay between 16 and 33 days. Due to the small number of cases available for analysis, it was not meaningful to cross‐classify the data according to various prognostic variables. Fifty percent of the transplants studied were paid for by private insurers, and reimbursement exceeded 80% of billed charges for 50.6% of the cases analyzed. Insurance reimbursement for pancreas transplantation is not uniform, but is favorable for those covered. While the number of procedures performed annually has increased since 1980, with the largest increases occurring since 1988, sustained growth may well be a function of insurance coverage. Many transplant centers are unable to bear the expense of pancreas transplants insurers fail to cover. As a result, access will be a problem for some patients.
Hyperacute rejection from antibody against class II HLA antigens
Authors: Ghasemian S Reza , Light Jimmy A , Sasaki Truman A , Barhyte Diana Y 
Published: September 2024

The clinical significance of anti‐B‐cell antibodies in kidney and pancreas transplantation remains unresolved. Here, we report an isolated hyperacute rejection of the kidney, but not the pancreas, during a simultaneous kidney‐pancreas (SKP) transplant. The hyperacute rejection was due to IgG antibodies directed against class II antigens expressed on B‐cells.Antibodies directed against class II antigens are generally not thought to produce hyperacute rejection, since class II antigens allegedly are minimally expressed on vascular endothelium in the kidney. The pancreas was spared and continues to function normally, suggesting that class II antigens were not strongly expressed in this pancreas. The differential susceptibility to B‐cell antibodies of the two transplanted organs is noteworthy and should call attention to the danger from IgG antibodies to class II antigens in kidney transplantation.
Cerebral mucormycosis after liver transplantation: a case report
Authors: Webb Marc , Dowdy Lorraine , Bundschu Claudia , Nery Jose , Schiff Eugene , Tzakis Andreas G 
Published: September 2024

A fatal case of cerebral mucormycosis occurring shortly after liver transplantation is described. The patient was a 32‐yr‐old male with advanced end‐stage liver disease manifested by tense ascites, spontaneous bacterial peritonitis, deepening jaundice and anuria requiring hemodialysis. The 3rd day after successful liver transplantation the patient developed acute respiratory failure, then focal motor signs. Computed tomography showed fluid in the left maxillary sinus, partial opacification of the ethmoid and sphenoid sinuses, and diffuse low density lesions in both cerebral hemispheres. Despite treatment for cerebritis and cerebral edema, the patient's pupils became fixed and dilated, and brain death was declared. Autopsy revealed mucor sinusitis and cerebritis.Mucormycosis is an opportunistic fungal infection occurring in patients with diabetic ketoacidosis, malignancy, or immunodeficiency, and in those receiving wide‐spectrum antibiotics, corticosteroids, or cytotoxic therapy. Mucor most frequently involves the face, rhinocerebral disease predominating. These infections are difficult to treat, but are curable with aggressive and frequent surgical debridement, discontinuation or reduction of immunosuppressive therapy and amphotericin. The diagnosis of mucormycosis is very difficult to make in cases such as the present one, in which the typical presentation and classical signs are not present. A high index of suspicion based on identified risk factors may assist in more rapid diagnosis of this life‐threatening mycosis.
Lying to Make Friends
Authors: Richards Charlie 
Published: September 2024

ABSTRACTIt is intuitively wrongful to deceive people into forming a false belief. It is especially intuitively wrongful to deceive people into forming the false belief that you are their friend. Despite these intuitions, this article argues that in a surprising number of cases, deceiving people into believing you are their friend is not only permitted, but required. The article uses this result to make some important revisions and suggestions for the emergent social rights literature: (i) it shows that social rights are feasible in a wider range of cases than previously thought, and (ii) it casts doubt on whether grounding such rights on the impersonal value of genuine intimate relationships is their most fruitful grounding.
LncRNA–miRNA interactions prediction based on meta‐path similarity and Gaussian kernel similarity
Authors: Xie Jingxuan , Xu Peng , Lin Ye , Zheng Manyu , Jia Jixuan , Tan Xinru , Sun Jianqiang , Zhao Qi 
Published: September 2024

AbstractLong non‐coding RNAs (lncRNAs) and microRNAs (miRNAs) are two typical types of non‐coding RNAs that interact and play important regulatory roles in many animal organisms. Exploring the unknown interactions between lncRNAs and miRNAs contributes to a better understanding of their functional involvement. Currently, studying the interactions between lncRNAs and miRNAs heavily relies on laborious biological experiments. Therefore, it is necessary to design a computational method for predicting lncRNA–miRNA interactions. In this work, we propose a method called MPGK‐LMI, which utilizes a graph attention network (GAT) to predict lncRNA–miRNA interactions in animals. First, we construct a meta‐path similarity matrix based on known lncRNA–miRNA interaction information. Then, we use GAT to aggregate the constructed meta‐path similarity matrix and the computed Gaussian kernel similarity matrix to update the feature matrix with neighbourhood information. Finally, a scoring module is used for prediction. By comparing with three state‐of‐the‐art algorithms, MPGK‐LMI achieves the best results in terms of performance, with AUC value of 0.9077, AUPR of 0.9327, ACC of 0.9080, F1‐score of 0.9143 and precision of 0.8739. These results validate the effectiveness and reliability of MPGK‐LMI. Additionally, we conduct detailed case studies to demonstrate the effectiveness and feasibility of our approach in practical applications. Through these empirical results, we gain deeper insights into the functional roles and mechanisms of lncRNA–miRNA interactions, providing significant breakthroughs and advancements in this field of research. In summary, our method not only outperforms others in terms of performance but also establishes its practicality and reliability in biological research through real‐case analysis, offering strong support and guidance for future studies and applications.
Bayesian material flow analysis for systems with multiple levels of disaggregation and high dimensional data
Authors: Wang Junyang , Ray Kolyan , Brito‐Parada Pablo , Plancherel Yves , Bide Tom , Mankelow Joseph , Morley John , Stegemann Julia A. , Myers Rupert 
Published: September 2024

AbstractMaterial flow analysis (MFA) is used to quantify and understand the life cycles of materials from production to end of use, which enables environmental, social, and economic impacts and interventions. MFA is challenging as available data are often limited and uncertain, leading to an under‐determined system with an infinite number of possible stocks and flows values. Bayesian statistics is an effective way to address these challenges by principally incorporating domain knowledge, quantifying uncertainty in the data, and providing probabilities associated with model solutions. This paper presents a novel MFA methodology under the Bayesian framework. By relaxing the mass balance constraints, we improve the computational scalability and reliability of the posterior samples compared to existing Bayesian MFA methods. We propose a mass‐based, child and parent process framework to model systems with disaggregated processes and flows. We show posterior predictive checks can be used to identify inconsistencies in the data and aid noise and hyperparameter selection. The proposed approach is demonstrated in case studies, including a global aluminum cycle with significant disaggregation, under weakly informative priors and significant data gaps to investigate the feasibility of Bayesian MFA. We illustrate that just a weakly informative prior can greatly improve the performance of Bayesian methods, for both estimation accuracy and uncertainty quantification.
‘We Can Win this Fight Together’: Memory and Cross‐Occupational Coordination
Authors: Noh Sung‐Chul , Lyle Matthew C. B. , Do Boram 
Published: September 2024

AbstractWhile scholars have studied coordination across occupational lines, they have yet to theorize how the memories held by those involved in such coordination might influence it. In this paper, we frame occupational groups as mnemonic communities – collectives for whom a shared understanding of the past constitutes their character – to explore the role of memory in cross‐occupational coordination (COC). Through qualitative analysis of a South Korean broadcasting company in which COC emerged for the purpose of collective action, we develop a theory of cross‐occupational mnemonic (dis)unity. Our findings suggest that, initially, cross‐occupational relational memories (i.e., memories occupations held of themselves, other occupations and their relationships) constrained COC as they maintained occupational divides. However, one occupation's efforts to downplay these memories, coupled with an event experienced and remembered across occupational lines, resulted in COC by producing a cross‐occupational mnemonic community. These findings extend research at the intersection of occupations and memory by theorizing the mutability of occupational groups, perhaps the most prominent intra‐organizational mnemonic communities.
Prevalence of Painful Temporomandibular Disorder Symptoms Among Professional and Student Musicians: An Online Survey
Authors: Z'Graggen Suzanne , Ettlin Dominik A. , Alessandri Elena , Z'Graggen Werner J. , Schimmel Martin 
Published: September 2024

ABSTRACTBackgroundWithin the fields of medicine and music, increasing attention is given to evidence indicating music performance being an occupational risk factor for temporo‐mandibular disorders (TMD).ObjectivesAssessment of self‐reported painful TMD symptoms among student and professional musicians.MethodsUsing Survey Monkey software, the German version of the ‘TMD‐Pain‐Screener’ was distributed electronically to professional and student musicians in Europe. Supplementary questions addressed age, gender, daily playtime, instrument type and type of professional practice. Results are presented as median [interquartile range].ResultsThe TMD‐pain‐screener was completed by 492 participants. Among them, 96 (19.5%) reported painful TMD (Pain_pos) and 396 did not experience pain (80.5%, Pain_neg). Pain_pos participants were significantly younger (Pain_pos: 34 years [26; 46], Pain_neg: 44 years [30; 56], p = 0.0003), had less work experience (Pain_pos: 15.5 years [6; 25], Pain_neg: 20 years [10; 32], p = 0.009), had fewer performances/year (Pain_pos: 20/year [10; 45], Pain_neg: 30/year [12; 53.5], p = 0.03) and were predominantly female (OR = 3.22 [1.87, 5.74], p < 0.0001). Comparisons among music performance types revealed no statistical significance in the overall test (p = 0.13), although ‘keyboard’ (OR = 2.99 [0.58, 30.12]), ‘upper string’ (OR = 2.31 [0.43, 23.63]) and ‘singer’ (OR = 2.14 [0.44, 20.75]) stood out compared to the reference group ‘lower string’ (OR 1.00). Organ players formed the largest group and showed a comparatively low prevalence of Pain_pos (16%), compared to other keyboard instruments (Pain_pos 30.2%).ConclusionsPrevalence of TMD pain was highest among young inexperienced female musicians. Playing keyboard instruments (other than organ) or upper strings instruments were frequently associated with painful TMD screening. An improved understanding of causes, implementation of preventive measures, professional guidance and a biopsychosocial health care perspective may decrease this occupational risk while maintaining the health benefits of music.
Music cue during slow wave sleep improves visuospatial memory consolidation
Authors: Fabbri Marco , Occhionero Miranda , Tonetti Lorenzo , Costa Marco , Giudetti Federica , Rasch Bjoern , Natale Vincenzo 
Published: September 2024

SummaryThe active system consolidation theory assumes that sleep between encoding and retrieval promotes memory consolidation. In the present study, we cued new memories during slow‐wave (SWS) or rapid eye movements (REM) sleep stages by presenting an instrumental music stimuli that had been previously presented during a learning session. In a within‐subjects design, 18 participants slept for three nonconsecutive nights (cue during SWS, cue during REM, and no cue during control night) and were trained in a visuo‐spatial memory task. The administration of cue during SWS produced better memory accuracy in comparison with REM and the control condition.
Night life: Positional behaviors and activity patterns of the Neotropical kinkajou, Potos flavus (Carnivora, Procyonidae)
Authors: Mensah J. B. , Forget P.‐M. , Guilbert É. , Herrel A. , Ofori B. Y. , Naas A. G. 
Published: September 2024

AbstractStudying positional behaviors is important for understanding how animals interact with their immediate environment. This is particularly important in arboreal species since arboreal milieus are primarily characterized by three‐dimensional problems that arboreal species must overcome to efficiently access resources. Similarly, a fundamental aspect of an animal's ecology is its daily activity pattern. This information is important for understanding the basic ecology of animal species and their eco‐evolutionary dynamics. This study sought to understand the habitat use and nocturnal lifestyle of the highly arboreal kinkajou (Potos flavus) by documenting variation in positional behaviors and activity patterns using 2223 photographs obtained from 27 camera traps in French Guiana. Data were analyzed using descriptive statistics, Kernel density estimation (KDE), and Gantt charts. Our results indicate that kinkajous show a strictly nocturnal activity pattern beginning from 19:00 h to 05:57 h, with peak active periods between 01:00 h and 02:00 h. The most frequent activities were scanning (48.33%) and traveling (47.13%). Quadrupedal walking (95.43%) was the main locomotor behavior during traveling. However, when crossing gaps between two substrates, kinkajous would either bridge (42.22%), leap (33.33%), or drop (26.67%) across gaps. Inactive periods were characterized by grooming (77.32%) and resting (27.84%) while mostly assuming a sitting (90.67%) or a catlike body curl posture (92.59%), interchangeably. This study highlights the broad array of positional behaviors displayed by kinkajous, further providing information to understand its basic ecology and eco‐evolutionary dynamics.
The Arpu Kuilpu meteorite: In‐depth characterization of an H5 chondrite delivered from a Jupiter Family Comet orbit
Authors: Anderson Seamus L. , Benedix Gretchen K. , Godel Belinda , Alosius Romain M. L. , Krietsch Daniela , Busemann Henner , Maden Colin , Friedrich Jon M. , McMonigal Lara R. , Welten Kees C. , Caffee Marc W. , Macke Robert J. , Cadogan Seán , Ryan Dominic H. , Jourdan Fred , Mayers Celia , Laubenstein Matthias , Greenwood Richard C. , Roberts Malcom P. , Devillepoix Hadrien A. R. , Sansom Eleanor K. , Towner Martin C. , Cupák Martin , Bland Philip A. , Forman Lucy V. , Fairweather John H. , Rogers Ashley F. , Timms Nicholas E. 
Published: September 2024

AbstractOver the Nullarbor Plain in South Australia, the Desert Fireball Network detected a fireball on the night of June 1, 2019 (7:30 pm local time), and 6 weeks later recovered a single meteorite (42 g) named Arpu Kuilpu. This meteorite was then distributed to a consortium of collaborating institutions to be measured and analyzed by a number of methodologies including SEM‐EDS, EPMA, ICP‐MS, gamma‐ray spectrometry, ideal gas pycnometry, magnetic susceptibility measurement, μCT, optical microscopy, and accelerator and noble gas mass spectrometry techniques. These analyses revealed that Arpu Kuilpu is an unbrecciated H5 ordinary chondrite, with minimal weathering (W0‐1) and minimal shock (S2). The olivine and pyroxene mineral compositions (in mole%) are Fa: 19.2 ± 0.2 and Fs: 16.8 ± 0.2, further supporting the H5 type and class. The measured oxygen isotopes are also consistent with an H chondrite (δ17O‰ = 2.904 ± 0.177; δ18O‰ = 4.163 ± 0.336; Δ17O‰ = 0.740 ± 0.002). Ideal gas pycnometry measured bulk and grain densities of 3.66 ± 0.02 and 3.77 ± 0.02 g cm−3, respectively, yielding a porosity of 3.0% ± 0.7. The magnetic susceptibility of this meteorite is log χ = 5.16 ± 0.08. The most recent impact‐related heating event experienced by Arpu Kuilpu was measured by 40Ar/39Ar chronology to be 4467 ± 16 Ma, while the cosmic ray exposure age is estimated to be between 6 and 8 Ma. The noble gas isotopes, radionuclides, and fireball observations all indicate that Arpu Kuilpu's meteoroid was quite small (maximum radius of 10 cm, though more likely between 1 and 5 cm). Although this meteorite is a rather ordinary ordinary chondrite, its prior orbit resembled that of a Jupiter Family Comet (JFC) further lending support to the assertion that many cm‐ to m‐sized objects on JFC orbits are asteroidal rather than cometary in origin.
Effects of Beraprost on Intestinal Microcirculation and Barrier Function in a Mouse Model of Renal Failure
Authors: Hirano Akira , Kadoya Hiroyuki , Takasu Masanobu , Iwakura Tsukasa , Kajimoto Eriko , Tatsugawa Rie , Matsuura Takumi , Kurumatani Hajimu , Yamamoto Toshiya , Kidokoro Kengo , Kishi Seiji , Nagasu Hajime , Sasaki Tamaki , Kashihara Naoki 
Published: September 2024

ABSTRACTObjectiveEndothelial dysfunction plays an important role in the pathogenesis of chronic kidney disease. Prostacyclin (PGI2), an endothelial cell‐produced endogenous prostaglandin, plays a crucial role in maintaining endothelial function. However, its effects on intestinal microcirculation and barrier function are not fully understood. We hypothesized that PGI2 improves intestinal microcirculation and barrier function via endothelial protective effects.MethodsICR and ICGN (a spontaneous nephrotic model) mice were used in this study. Intestinal microcirculation was visualized in vivo to investigate PGI2 effects. Beraprost served as PGI2. PGI2 administration spanned 4 weeks, following which we assessed its influence on intestinal endothelial, intestinal barrier, and renal functions.ResultsWe visualized intestinal microcirculation and endothelial glycocalyx in the intestinal blood vessels. Beraprost administration induced a 1.2‐fold dilatation of the vascular diameter of the small intestine. Intestinal blood flow in ICGN mice was significantly reduced compared that in ICR mice but improved with beraprost administration. ICGN mice exhibited reduced serum albumin levels, decreased ambulation, an imbalance in intestinal reactive oxygen species (ROS)/nitric oxide (NO), and impaired tight junctions; all were ameliorated by beraprost administration.ConclusionsBeraprost improves intestinal microcirculation and barrier function by ameliorating ROS/NO imbalances, thereby reducing physical inactivity during renal failure.