bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Coordination Compounds of Indium. Part 46. Indium(I) Derivatives of 3,5‐Di‐tert.‐butyl‐1,2‐o‐benzoquinone.
Authors: ANNAN T. A. , MCCONVILLE D. H. , MCGARVEY B. R. , OZAROWSKI A. , TUCK D. G. 
Published: May 2016

AbstractIn metal (II) reacts with the o‐benzoquinone (I) to give a solution of the corresponding semiquinone‐In(I) complex (III) which can be stabilized in the solid state as the neutral phenanthroline complex (V) or as the salt (VI).
ChemInform Abstract: Lead(II) Compounds with π‐Bonded Pentamethylcyclopentadienyl Ligands ‐ Syntheses, Structures, and Bonding Properties.
Authors: JUTZI P. , DICKBREDER R. , NOETH H. + 
Published: May 2016

AbstractThe reaction of (III) with PbCl2 leads to (I) or (IV) depending on the ratio of reactants.
ChemInform Abstract: 2,3‐Dihydrothiophene (2,3‐DHT) Complexes of Tungsten. Structure of W(CO)3(dppe)(2,3‐DHT).
Authors: GLAVEE G. N. , DANIELS L. M. , ANGELICI R. J. 
Published: May 2016

AbstractThe 2,3‐dihydrothiophene‐W complexes (III) and (V) are obtained according to the scheme and characterized by 1H NMR, IR, and mass spectral data as well as by X‐ray structure analysis of the title complex (IIIa) (space group P21/n, Z=4).
ChemInform Abstract: Electronic and CD Spectra of Catecholate and Semiquinonate Adducts of Zinc(II) and Nickel(II) Tetraaza Macrocyclic Complexes.
Authors: BENELLI C. , DEI A. , GATTESCHI D. , PARDI L. 
Published: May 2016

AbstractThe electrochemical properties, and the electronic and CD spectra of dioxolene adducts (I) and (II) containing the racemic and the (‐)‐SS isomer of the macrocyclic ligand are reported.
ChemInform Abstract: Diterpenoid Total Synthesis. Part 27. Synthesis and Structure Revision of Bifurcarenone, a Unique Monocyclic Diterpene in Combination with a Hydroquinone C7 Unit as an Inhibitor of Mitotic Cell Division.
Authors: MORI K. , UNO T. 
Published: May 2016

AbstractThe first total synthesis of racemic bifurcarenone, a C27 hydroquinone isolated from the brown seaweed Bifurcaria galapagensis, is reported and its structure is shown to be (I).
ChemInform Abstract: Boron Anellation in Organic Synthesis. Part 3. Stereoselectivity and the Formal Synthesis of (.+‐.)‐Helenalin.
Authors: WELCH M. C. , BRYSON T. A. 
Published: May 2016

AbstractThe divinylcyclopentane (I) is transformed into the fused cycloheptanones (III) by different methods: reaction with thexylborane and sodium cyanide (II) favours the formation of the isomer (IIIb), whereas treatment of (I) with bromoborane followed by cyclocondensation with dichloromethyl methyl ether (IV) gives predominantly the diastereomer (IIIa) which is a precursor of helenalin (V).
ChemInform Abstract: Molecular Modeling of γ‐Lactam Analogues of β‐Lactam Antibacterial Agents: Synthesis and Biological Evaluation of Selected Penem and Carbapenem Analogues.
Authors: ALLEN N. E. , BOYD D. B. , CAMPBELL J. B. , DEETER J. B. , ELZEY T. K. , FOSTER B. J. , HATFIELD L. D. , HOBBS J. N. JUN. , HORNBACK W. J. , HUNDEN D. C. , JONES N. D. , KINNICK M. D. , MORIN J. M. JUN. , MUNROE J. E. , SWARTZENDRUBER J. K. , VOGT D. G. 
Published: May 2016

AbstractFrom computational chemistry studies it is suggested that γ‐lactam analogues of penems and carbapenems possessing a 7β‐acylamino side‐chain present the pharmacophoric groups in close spatial similarity to the groups in biologically active cephalosporin and penicillin antibiotics.
ChemInform Abstract: Ferroelectric Liquid Crystals. Part 9. Laterally Substituted Phenyl Benzoates Incorporating a trans‐1,4‐Disubstituted Cyclohexane Ring.
Authors: KELLY S. M. 
Published: May 2016

AbstractMore than 65 benzoates of type (I)‐(III) are synthesized including some 4‐((S)‐(1‐methylheptyl))oxy benzoates of types (I) and (III).
ChemInform Abstract: Charge Transfer Process at Illuminated Semiconductor/Electrolyte Junctions Modified by Electrodeposition of Microscopic Metal Grain.
Authors: ALLONGUE P. , SOUTEYRAND E. , ALLEMAND L. 
Published: May 2016

AbstractElectrocrystallization is employed to deposit transparent layers of microscopic Pt grains on n‐GaAs electrodes.
ChemInform Abstract: Molecular Beam Epitaxy Growth of Ge on (100) Si.
Authors: BARIBEAU J.‐M. , HOUGHTON D. C. , JACKMAN T. E. , MCCAFFREY J. P. 
Published: May 2016

AbstractThe initial stage of epitaxial growth of Ge on Si (100) is studied as a function of substrate temp. in order to determine the most suitable growth conditions.
ChemInform Abstract: Synthesis of Novel Carbo‐ and Heteropolycycles. Part 13. Thermal Cycloaddition Reactions of 4,5‐Epoxy‐4‐azahomoadamantanes with Acetylenic 1,3‐Dienophiles. Novel Formation of 4‐Azahomoadamantano(4,5‐a)pyrrole Derivatives.
Authors: EGUCHI S. , ASAI K. , SASAKI T. 
Published: May 2016

AbstractThe 4,5‐epoxy‐4‐azahomoadamantane (I) reacts with dimethyl acetylenedicarboxylate (II) to give predominantly the cycloadduct (III).
ChemInform Abstract: Novel Bis‐α‐diketones from Fluoranthene.
Authors: CHAIKOSKII V. K. , ELISEEV V. N. 
Published: May 2016

AbstractOxidation of the phenylethinylfluoranthene (I) gives the phenylglyoxal (II) which is dimerized in the presence of PdCl2, producing the bifluoranthene (III).
ChemInform Abstract: Synthesis of Derivatives of 3‐Hydroxymethyl‐3‐phenylazetidine and Attempted Conversions to 3‐Phenyl‐1‐azabicyclo(1.1.1)pentane or 3‐Phenyl‐1‐azabicyclo(2.1.1)hexane.
Authors: ANDERSON A. G. JUN. , JEWELL R. A. 
Published: May 2016

AbstractThe preparation of a series of new title compounds is reported.
ChemInform Abstract: A (3 + 2)Cycloaddition Strategy to the Phyllanthocin Ring System.
Authors: TROST B. M. , MOELLER K. D. 
Published: May 2016

AbstractIntramolecular, Pd‐catalyzed cyclization of the aldehydes (I), (III), and (VI) yields the fused methylidene‐O‐heterocycles (II), (IV) and (V) or (VII).
ChemInform Abstract: Benz‐Fused Lactones. Part 1. Synthesis of 3‐Methyl‐1(3H)‐isobenzofuranones (Phthalides).
Authors: BOULET C. A. , POULTON G. A. 
Published: May 2016

AbstractThe benzoic acids (I) are converted via the corresponding benzamides into the 2‐aryl‐4,4‐dimethyl‐2‐oxazolines (III).
ChemInform Abstract: Benzimidazole‐Condensed Ring Systems. Part 2. New Synthesis of Substituted 1‐Oxo‐1H,5H‐pyrido(1,2‐a)benzimidazole‐4‐carbonitriles and Related Derivatives.
Authors: RIDA S. M. , SOLIMAN F. S. G. , BADAWEY EL‐S. A. M. , KAPPE T. 
Published: May 2016

AbstractThe key step in the synthesis of the target compounds is the cyclocondensation reaction of 2‐(cyanomethyl)benzimidazole (I) with the β‐keto esters (II) or (X) or the related enamine (IV), yielding the pyridobenzimidazoles (III) or (XI).
ChemInform Abstract: Synthesis and Properties of Unusually Stable, Heterocyclic Nitrilium Ylides.
Authors: PFLEIDERER W. 
Published: May 2016

AbstractHeating of 1,3‐dimethyllumazine (Ia) in the solid state results in ring contraction, yielding 9‐cyano‐1,3‐dimethylxanthine (II).
ChemInform Abstract: High‐Pressure Approach to the Synthesis of N,N′‐Dimethyl Diazacoronands.
Authors: JURCZAK J. , OSTASZEWSKI R. , SALANSKI P. 
Published: May 2016

AbstractAlkylation of the tertiary diamines (I) and (VI) with the diiodides (II) and (V) under pressure yields the cyclic ammonium salts (III) and (VII) which are demethylated upon treatment with triphenylphosphine to produce the N,N'‐dimethyl diazacoronands (IV) and (VIII).
ChemInform Abstract: Phosphorus‐Nitrogen Compounds. Part 58. The Reactions of Hexachlorocyclotriphosphatriene with Ethane‐, 1,3‐Propane‐, and 1,4‐Butanediols. Spiro, Ansa, Bridged, and Dangling Derivatives and Their 31P and 1H Nuclear Magnetic Resonance Spectra.
Authors: ALKUBAISI A. H. , PARKES H. G. , SHAW R. A. 
Published: May 2016

AbstractEthanediol (II) and 1,3‐propanediol (V) undergo cyclocondensation reaction with the hexachloride (I) to give the spiroheterocycles (III), (VI), and (X) as the main products.
ChemInform Abstract: Structural and Complexation Properties of 2,11‐Diselena(3.3)(2,6)pyridinophane.
Authors: MURALIDHARAN S. , HOJJATIE M. , FIRESTONE M. , FREISER H. 
Published: May 2016

AbstractThe title compound (IV) is synthesized from 2,6‐bis(bromomethyl)pyridine (I) and potassium selenocyanate (II) using the high dilution method.
ChemInform Abstract: Synthesis and Reactivity of Some Organozinc Compounds in Solvents Unusual in Organometallic Chemistry.
Authors: GRONDIN J. , SEBBAN M. , VOTTERO P. , BLANCOU H. , COMMEYRAS A. 
Published: May 2016

AbstractThe alkyl bromides (I) react with freshly prepared active zinc (II)/ copper couple in diethyl carbonate to form the alkylzinc bromides (III) which are treated with acetyl chloride (IV), yielding the methyl ketones (V).
ChemInform Abstract: Phenolic Congeners of Colchicine: Preparation and Characterization of Phenolic and Catecholic Analogues of Colchicine, Colchiceine, and Thiocolchicine.
Authors: MUZAFFAR A. , CHRZANOWSKA M. , BROSSI A. 
Published: May 2016

AbstractAcid‐catalyzed demethylation of 2‐demethylcolchicine (I) yields 1,2‐didemethylcolchicine (II) and 2,3‐didemethylcolchicine (III) which undergo further cleavage reaction on treatment with hydrochloric acid, producing the colchiceines (IV) and (V).
ChemInform Abstract: Methoxysubstituted 1,2‐Aminothiols. Antioxidants of Lubricating Oils.
Authors: ALLACHVERDIEV M. A. , GUSEINOVA A. T. , FARZALIEV V. M. , SULTANOV YU. M. , IBRAGIMOV N. YU. 
Published: May 2016

AbstractThe title compounds (III) are prepared for the first time.
Probing the Methyl Torsional Barriers of the E and Z Isomers of Butadienyl Acetate by Microwave Spectroscopy
Authors: Jabri Atef , Van Vinh , Nguyen Ha Vinh Lam , Stahl Wolfgang , Kleiner Isabelle 
Published: May 2016

AbstractThe Fourier transform microwave spectra of the E and Z isomers of butadienyl acetate were measured in the frequency range from 2 to 26.5 GHz under molecular‐jet conditions. The most stable conformer of each isomer, in which all heavy atoms are located in a symmetry plane, was identified after analyzing the spectrum by comparison with the results from quantum‐chemical calculations. The barriers to internal rotation of the acetyl methyl group were found to be 149.1822(20) and 150.2128(48) cm−1 for the E and Z isomers, respectively, which are similar to that of vinyl acetate. A comparison between two theoretical approaches treating internal rotation, the rho axis method and combined axis method, was also performed. The influence of the alkyl R chain on the methyl torsional barriers in CH3‐COOR acetates was explored.
Functional mitral regurgitation at discharge and outcomes in patients hospitalized for acute decompensated heart failure with a preserved or reduced ejection fraction
Authors: Kajimoto Katsuya , Sato Naoki , Takano Teruo ,   on behalf of the investigators of the Acute Decompensated Heart Failure Syndromes (ATTEND) registry
Published: May 2016

AbstractAimsThe relationship between functional mitral regurgitation (FMR), left ventricular ejection fraction (EF), and outcomes is unclear in acute decompensated heart failure (HF) patients. The aim of this study was to evaluate the relationship between FMR and post‐discharge outcomes in HF patients with a preserved or reduced EF.Methods and resultsOf the 4842 patients enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, 3357 patients were evaluated to assess the association among FMR (none, mild, or moderate/severe) at discharge, a preserved or reduced EF, and the primary endpoint (all‐cause mortality and readmission for HF). The median follow‐up period after discharge was 530 (387–800) days. According to multivariate analysis, patients with either mild FMR or moderate/severe FMR from the preserved EF group had a significantly higher risk of reaching the endpoint than patients without FMR [hazard ratio (HR) 1.40; 95% confidence interval (CI) 1.14–1.72; P = 0.001 and HR 1.40; 95% CI 1.09–1.81; P = 0.009, respectively]. In the reduced EF group, patients with moderate or severe FMR had a significantly higher risk relative to patients without FMR (HR 1.41; 95% CI 1.07–1.86; P = 0.015), but there was no significant association of mild FMR with the risk of reaching the endpoint (HR 1.09; 95% CI 0.84–1.42; P = 0.510).ConclusionOur findings demonstrate that even mild FMR is associated with an increased risk of adverse outcomes in HF patients with a preserved EF, while moderate or severe FMR (but not mild FMR) is associated with adverse outcomes in HF patients with a reduced EF.
Development of an Electrochemical Immunoassay for the Detection of Polybrominated Diphenyl Ethers (PBDEs)
Authors: Bettazzi Francesca , Martellini Tania , Shelver Weilin L. , Cincinelli Alessandra , Lanciotti Eudes , Palchetti Ilaria 
Published: May 2016

AbstractPolybrominated diphenyl ethers (PBDEs) are persistent environmental substances that were commonly used as fire retardants in a wide number of commercial products. Their low reactivity, high hydrophobicity and bioaccumulative properties cause their ubiquity in the air, water, food and lead to extensive exposure of world population to these compounds. The severe health problems caused by PBDEs lead them to be banned from the market. In March 2014 the European Commission issued a recommendation in which member states are requested to monitor brominated flame retardants in food, in order to evaluate human and wildlife exposure. Here, we described the development of an electrochemical magnetic particle enzyme‐linked immunoassay to analyze PBDEs in food samples. The immunological reaction is based on a competitive scheme, using an alkaline phosphatase labeled congener as tracer. The anti‐PBDE antibody modified magnetic particles are captured on the surface of carbon disposable array of sensors. The reaction extent is finally electrochemically measured by differential pulse voltammetry, upon the addition of substrate. Under the optimized conditions, a limit of detection of 0.18 ng/mL with a limit of quantification of 0.30 ng/mL and a quantification range of 0.30–6.9 ng/mL, (RSD%=12) is obtained. Results of food samples obtained from the newly developed electrochemical immunoassay are also reported.
Stimulating effect of both 4’‐O‐methylnorbelladine feeding and temporary immersion conditions on galanthamine and lycorine production by Leucojum aestivum L. bulblets
Authors: Saliba Sahar , Ptak Agata , Boisbrun Michel , Spina Rosella , Dupire François , Laurain‐Mattar Dominique 
Published: May 2016

Bulb cultures of Leucojum aestivum and L. aestivum ‘Gravety Giant’ were subcultured in medium containing the precursor 4’‐O‐methylnorbelladine (MN) at various concentrations [0 (control), 0.15 and 0.3 g/L]. The cultures were conducted in bioreactor RITA® and lasted for 15, 30, 40 and 50 days. The growth rate and the alkaloid accumulation in bulblets were studied. For this latter purpose, a purification method was developed. It comprised a highly selective solid phase extraction using on the one hand, UPTI‐CLEAN SI and SCX cartridges for plant extracts and on the other hand, 2H cartridges for culture media. Pure alkaloidal fractions were, thus, analyzed by LC‐ESI‐MS allowing the quantitative evaluation of galanthamine and lycorine from culture extracts. Precursor feeding along with temporary immersion conditions was found to significantly improve the accumulation of both galanthamine and lycorine. The maximal concentrations of galanthamine (0.81 mg/g DW) and lycorine (0.54 mg/g DW) in L. aestivum bulblets were reached, respectively, after 40 days of culture with 0.15 g/L of precursor and after 30 days of culture with 0.3 g/L of precursor. In L. aestivum ‘Gravety Giant’ bulb cultures, 0.3 g/L of precursor was the best condition for both galanthamine (0.6 mg/g DW after 50 days) and lycorine (1.13 mg/g DW after 30 days).
Stratigraphic correlations and occurrence patterns of two sets of Lower Cretaceous black shales in coastal southeastern China and geological implications: insights from zircon U–Pb ages
Authors: Hu Guang , Hu Wenxuan , Cao Jian , Yao Suping 
Published: May 2016

AbstractLower Cretaceous black shales in coastal southeastern China are of significance to the geological study of the Pacific tectonic domains. However, the stratigraphic correlations and occurrence patterns of the shales have not been well constrained so far. To address these limitations, 131 new zircon U–Pb dates were obtained from the tuff layers, which were interlayered with the shales from four outcrops. In combination with previously reported geochronological data, the stratigraphic correlations and occurrence patterns of the black shales were discussed. Results show that the black shales in the Shuidishan Formation (~145 Ma) in the Dayawan section, northern Guangdong, are older than those in the lower part of the Bantou Formation (~132 Ma) in the northward Yong'an section, southern Fujian, whereas they are roughly isochronous to the base of the Bantou Formation (~144 Ma). In contrast, the black shales in the upper part of the Bantou Formation (~117 Ma) from the Yong'an section in northwestern Fujian and the black shales in the Shixi Formation (~117 Ma) from the Yiyang section in northeastern Jiangxi can be isochronously correlated with the black shales in the Bantou Formation (~117 Ma) from the Chong'an section in northwestern Fujian, and they are slightly older than those in the Guantou Formation (~113 Ma) from the Shangzhang and Xiahuyuan sections in western Zhejiang. Black shales in Units I and II of the Shipu Group (~113–109 Ma) in northeastern Zhejiang can be isochronously correlated with those in the Guantou Formation (~113–106 Ma) in western Zhejiang. These new stratigraphic correlations indicate that the Lower Cretaceous black shales in coastal southeastern China can be divided into two regional‐scale sets. The first set was deposited during the early Early Cretaceous (Berriasian–Hauterivian) and is diachronous (i.e. 144 ± 2 Ma in the Dayawan section and 132 ± 2 Ma in the Yong'an section). The second set of black shales was deposited during the later Early Cretaceous and was roughly isochronous (~117 Ma). These results imply that the processes of the Pacific plate subduction in coastal southeastern China during the Early Cretaceous varied in two distinct stages that are identified by two volcanic–black shale cycles (i.e. ~145–120 and ~120–100 Ma). The distribution of the first set of black shales may extend to offshore basins in the South China Sea, whereas the second set may extend to the Taiwan Strait. Both sets are likely to be potential petroleum prospects. Copyright © 2016 John Wiley & Sons, Ltd.
A novel blood incubation system for the in‐vitro assessment of interactions between platelets and biomaterial surfaces under dynamic flow conditions: The Hemocoater
Authors: Boudot Cécile , Boccoz Ana , Düregger Katharina , Kuhnla Ariane 
Published: May 2016

AbstractHemocompatibility evaluation of biomaterials necessitates the use of blood incubation systems which simulate physiological flow conditions. However, most of the current systems have various limitations, especially restricted material variability, poor access to the test surface or damage of blood cells due to the use of a pump. In this paper, we combined the advantages of existent setups and developed a new planar shaped incubation test bench to lift those restrictions and mimic the pulsatile in‐vivo situation. The adjustable flow conditions at the tested material surface were defined and corresponded to those in blood vessels. Platelet/material‐interaction, as major aspect of hemocompatibility, was investigated for four common polymeric materials (polyoxymethylene, polypropylene, polyethylene and silicone elastomer) with platelet deprivation and platelet adhesion tests. Highly significant differences in the adhesion of platelets onto the tested material surfaces were measured. The number of adhered platelets on the most hydrophobic sample (silicone elastomer) was four‐times higher than on the most hydrophilic sample (polyoxymethylene). These findings were confirmed with a scanning microscopic analysis and demonstrated the suitability of the testing device for the evaluation of platelet/material interactions. Moreover, hemolysis measurements demonstrated that the system did not provoke blood damage. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2430–2440, 2016.
On the vagal cardiac nerves, with special reference to the early evolution of the head–trunk interface
Authors: Higashiyama Hiroki , Hirasawa Tatsuya , Oisi Yasuhiro , Sugahara Fumiaki , Hyodo Susumu , Kanai Yoshiakira , Kuratani Shigeru 
Published: May 2016

ABSTRACTThe vagus nerve, or the tenth cranial nerve, innervates the heart in addition to other visceral organs, including the posterior visceral arches. In amniotes, the anterior and posterior cardiac branches arise from the branchial and intestinal portions of the vagus nerve to innervate the arterial and venous poles of the heart, respectively. The evolution of this innervation pattern has yet to be elucidated, due mainly to the lack of morphological data on the vagus in basal vertebrates. To investigate this topic, we observed the vagus nerves of the lamprey (Lethenteron japonicum), elephant shark (Callorhinchus milii), and mouse (Mus musculus), focusing on the embryonic patterns of the vagal branches in the venous pole. In the lamprey, no vagus branch was found in the venous pole throughout development, whereas the arterial pole was innervated by a branch from the branchial portion. In contrast, the vagus innervated the arterial and venous poles in the mouse and elephant shark. Based on the morphological patterns of these branches, the venous vagal branches of the mouse and elephant shark appear to belong to the intestinal part of the vagus, implying that the cardiac nerve pattern is conserved among crown gnathostomes. Furthermore, we found a topographical shift of the structures adjacent to the venous pole (i.e., the hypoglossal nerve and pronephros) between the extant gnathostomes and lamprey. Phylogenetically, the lamprey morphology is likely to be the ancestral condition for vertebrates, suggesting that the evolution of the venous branch occurred early in the gnathostome lineage, in parallel with the remodeling of the head–trunk interfacial domain during the acquisition of the neck. J. Morphol. 277:1146–1158, 2016. © 2016 Wiley Periodicals, Inc.