bluuebunny/crossref_metadata_2025_split huggingface dataset:
Das jhwh-Heiligtum am Garizim: ein archäologischer Befund und seine literar- und theologiegeschichtliche Einordnung
Authors: Hensel Benedikt 
Published: November 2017

AbstractNo later than the midst of the 5th century the recently discovered sanctuary on Mt.Gerizim was the cultic center of the SamarianYhwh-worshippers, later known as the Samaritans. The sanctuary was in every way comparable to its counterpart in Jerusalem. The author investigates the question why there is so little mentioning of the sanctuary in the Bible at all; only the location “Mount Gerizim” is mentioned a few times in the Tora. Albeit its obvious absence in the texts, there seem to be several, enciphered mentions of the Samaria sanctuary in the later part of the (Judean) canon (Ketubim and Nebi’im). Altogether they criticize the cult on Mt.Gerizim in this very indirect way. The author explores the texts 2 Kön 17,24-41 and 2 Chr 13 as examples for this enciphering and outlines the character of these polemics and the ideological-theological interest of the Judean authors.
The Strange Use of דגל in Song of Songs 5:10
Authors: Andruska J.L. 
Published: November 2017

Abstract
The use of the word דגל in the Song of Songs 5:10 has caused considerable confusion among commentators. Most occurrences of the word in the Song are thought to be related to an army or host carrying banners, except in 5:10, where this usage is said to make little sense. Scholars therefore interpret the woman’s use of דגל in 5:10 differently from when the man uses it to describe her awe-striking an unnerving appearance in 6:4 and 6:10. This has given some the impression that the lovers view each other differently. This article attempts to show that the description of דגל in 6:4 and 6:10 actually illuminates its meaning in 5:10, so that when the woman uses it to describe the physical appearance of the man, it communicates similar feelings of awe and fear, that is, an awe-striking and unnerving appearance.
Centrality in the Book of Ruth
Authors: Dekker John T. , Dekker Anthony H. 
Published: November 2017

Abstract
The mathematics of social network analysis may be employed to determine the central character in a narrative. In this article, a number of centrality measures are utilised in order to illuminate the issue of the central character in the Book of Ruth. The mathematical analysis surprisingly points to Boaz as being the most central character of the book, but highlights the fact that “centrality” is an elusive concept.
The Notion of God Reflected in the Lion Imagery of the Book of Hosea
Authors: Zimran Yisca 
Published: November 2017

Abstract
This article is concerned with Hosea’s political counsel in 5:12-15, and explores the content and unique meaning of the lion imagery presented in this unit. The prophet’s words and their theological root are clarified through a discussion of the meaning of the lion imagery in the book of Hosea, as well as through comparison with similar imagery found in the book of Isaiah and extra-biblical sources. This analysis illuminates the unique theological perspective that Hosea wishes to impart to the people: Through the image of a lion, Hosea conveys that God exercises full, absolute control over Israel. He emphasizes, however, that God’s power is not extended over other nations. Hosea’s worldview, as will demonstrate in the article, challenges biblical notions of the God of Israel’s universality, as well as certain extra-biblical notions of the power of other deities and authorities.
Assessment of postsurgical outcomes between different implants in patients with empty nose syndrome: A meta-analysis
Authors: Ma Zu-xia , Quan-Zeng  , Jie-Liu  , Hu Guo-hua 
Published: November 2017

Objectives The aim of this study was to evaluate the impact of surgery and different implant materials on subjective outcomes in patients with empty nose syndrome (ENS). Methods Postsurgical outcomes were assessed in a meta-analysis of patients with ENS who underwent treatment with different implants. Results We identified 122 relevant studies, and 6 were included in the meta-analysis (4 prospective trials and 2 randomized controlled trials). A significant difference was found between the preoperative and postoperative Sino-Nasal Outcome Test (SNOT) scores for different implants. With respect to implant materials, significant differences were observed between autografts/allografts (AG) and foreign material grafts (FGs). A subgroup analysis of different countries showed that more patients from China underwent surgical implant therapy than patients from other countries. Conclusions This meta-analysis suggests that surgery can improve the symptoms and SNOT scores of patients with ENS, AGs are more effective than FGs in patients with ENS, and that more patients from China undergo surgical implant therapy than patients from other countries.
Autologous Chondrocyte Implantation in Osteoarthritic Surroundings: TNFα and Its Inhibition by Adalimumab in a Knee-Specific Bioreactor
Authors: Ossendorff Robert , Grad Sibylle , Stoddart Martin J. , Alini Mauro , Schmal Hagen , Südkamp Norbert , Salzmann Gian M. 
Published: November 2017

Background: Autologous chondrocyte implantation (ACI) fails in up to 20% of cases. Advanced intra-articular degeneration paired with an inflammatory environment may be closely related to implantation failure. Certain cytokines have been identified to play a major role during early osteoarthritis. Purpose: To investigate the effects of tumor necrosis factor α (TNFα) and its potential inhibition by adalimumab on cartilage regeneration in an in vitro model of ACI. Study Design: Controlled laboratory study. Methods: Bovine articular chondrocytes were cultivated and transferred at passage 3 to fibrin-polyurethane scaffolds. Constructs were loaded by compression (10%-20% scaffold height) and shear (±25°) in a fully characterized multiaxial load (L) bioreactor to simulate clinical ACI or were subjected to free swelling (FS) conditions for a duration of 2 weeks. TNFα (20 ng/mL), adalimumab (10 µg/mL), or both were added to the medium. To assess the outcome, DNA, GAG (glycosaminoglycan), and total collagen were quantified, and gene expression of anabolic (collagen 2, aggrecan, cartilage oligomeric protein, proteoglycan 4), catabolic (matrix metalloproteinases [MMP] 3 and 13), dedifferentiation (collagen 1), and hypertrophy (collagen 10) markers and proinflammatory cytokines (TNFα, IL-1β) was analyzed. Histological evaluation was performed with safranin O/fast green, toluidine blue, and immunohistochemistry of collagen 1 and 2. Apoptosis was analyzed by immunolabeling of anti-active caspase 3. For statistical evaluation, nonparametric tests were chosen with a significance level of P < .05. Results: A general downregulation of anabolic and upregulation of catabolic markers was detected in the TNFα groups. Collagen 2 was suppressed by TNFα (FS, P = .029; L, P = .006), while MMP 3 was significantly upregulated (FS, P = .035; L, P = .001). Dynamic loading induced a chondrogenic response, which could not fully antagonize the effect of the cytokine. Adalimumab antagonized all effects of TNFα. The histological and immunohistochemical assessments demonstrated less matrix formation in the cytokine-only groups. TNFα induced apoptosis, and this effect was increased by loading. Conclusion: TNFα does negatively affect chondrogenesis under simulated ACI conditions. Both dynamic load and, more potentially, adalimumab showed the capability of antagonizing the negative effects. Clinical Relevance: Catabolic cytokine suppression (ie, TNFα inhibition) combined with compression and shear load may best meet the conditions for chondrogenesis in an osteoarthritic environment.
Two discursive frameworks concerning ideology in Australian industrial relations
Authors: Fry Simon , Mees Bernard 
Published: November 2017

AbstractThere are two discursive frameworks concerning ideology in Australian industrial relations. In many disciplines concerned with aspects of industrial relations, including political science, law and history, it is the traditional political ideologies of the industrial era which take centre stage: liberalism (classical, social and neoliberalism), socialism (Marxism, social democracy and labourism) and conservatism. By contrast, ideological issues in the discipline of employment relations are chiefly addressed in terms of Fox’s three analytical perspectives: unitarism, pluralism and radicalism. The disjunction between these parallel discourses goes largely unnoted in the literature of the relevant disciplines, which all tend to proceed using their own preferred approach without making reference to the other. This article critically explores the relationship between these two discourses and investigates the broader implications that the existence of the two different discursive traditions has for the analysis of industrial relations phenomena in Australia.
Improving End-of-Life Care Knowledge Among Senior Baccalaureate Nursing Students
Authors: Glover Toni L. , Garvan Cynthia , Nealis Rose M. , Citty Sandra W. , Derrico David J. 
Published: November 2017

Objective: It is imperative that nurses are proficient and comfortable providing care to patients at the end of life. Recent studies show that nurses’ knowledge of end-of-life care is less than optimal. Effective, evidence-based methods to infuse palliative and end-of-life care education into the undergraduate nursing curriculum are needed. Methods: A descriptive pre- and postassessment evaluating senior nursing students’ acquisition of knowledge on end-of-life care after attending the End-of-Life Nursing Education Consortium (ELNEC) core course was conducted. The course evaluation included qualitative statements. Results: Before the ELNEC course, one-third of the students had cared for a dying patient during clinical rotations, yet 85% reported they had not received adequate training in end-of-life care. Posttest questions related to palliative care, symptom management, communication, and grief indicated that students acquired significant knowledge after participating in the ELNEC course ( P < .05). Conclusion: The ELNEC core course is an effective way to improve nursing students’ knowledge of palliative and end-of-life care.
Intensive Exposure and Response Prevention for Adolescent Body Dysmorphic Disorder With Comorbid Obsessive–Compulsive Disorder and Major Depressive Disorder
Authors: Le Thien-An P. , Merricks Katie , Nadeau Joshua M. , Ramos Amaya , Storch Eric A. 
Published: November 2017

Body dysmorphic disorder (BDD) primarily onsets during adolescence, and symptoms typically worsen when left untreated. Although use of cognitive-behavioral therapy (CBT) has established efficacy for adults with BDD, there is limited research and few case studies to suggest the same for adolescents and children. The present case describes the implementation of intensive (daily) treatment for Erin (pseudonym), a 17-year-old Caucasian female with primary BDD, as well as comorbid obsessive–compulsive disorder (OCD) and major depressive disorder (MDD), who was initially nonresponsive to outpatient supportive psychotherapy and pharmacotherapy. Treatment consisted of exposure and response prevention (ERP), concurrent with behavioral activation (BA). At discharge, Erin’s total score on the Children’s Yale–Brown Obsessive Compulsive Scale–Self-Report version (CY-BOCS-SR) decreased from 32 ( extreme severity) at pretreatment to 11 ( mild severity), as well as demonstrating improvement on other self-report measures. Despite significant reductions in ritual engagement, Erin’s symptoms never fully remitted. Based on telephone contact with her mother, Erin discontinued ERP upon returning home, where treatment gains were not maintained and symptoms returned to baseline severity. Thus, this case study demonstrates the effectiveness of intensive ERP for adolescent BDD, as well as demonstrating the lack of gain durability associated with withdrawing early from treatment. Furthermore, this case demonstrates that withdrawal from ERP prior to complete remission may lead to a resurgence of symptoms, thus making previous progress obsolete.
Isokinetic Extension Strength Is Associated With Single-Leg Vertical Jump Height
Authors: Fischer Felix , Blank Cornelia , Dünnwald Tobias , Gföller Peter , Herbst Elmar , Hoser Christian , Fink Christian 
Published: November 2017

Background: Isokinetic strength testing is an important tool in the evaluation of the physical capacities of athletes as well as for decision making regarding return to sports after anterior cruciate ligament (ACL) reconstruction in both athletes and the lay population. However, isokinetic testing is time consuming and requires special testing equipment. Hypothesis: A single-jump test, regardless of leg dominance, may provide information regarding knee extension strength through the use of correlation analysis of jump height and peak torque of isokinetic muscle strength. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 169 patients who underwent ACL reconstruction were included in this study. Isokinetic testing was performed on the injured and noninjured legs. Additionally, a single-leg countermovement jump was performed to assess jump height using a jump accelerometer sensor. Extension strength values were used to assess the association between isokinetic muscle strength and jump height. Results: The sample consisted of 60 female (mean age, 20.8 ± 8.3 years; mean weight, 61.7 ± 6.5 kg; mean height, 167.7 ± 5.3 cm) and 109 male (mean age, 23.2 ± 7.7 years; mean weight, 74.6 ± 10.2 kg; mean height, 179.9 ± 6.9 cm) patients. Bivariate correlation analysis showed an association ( r = 0.56, P < .001) between jump height and isokinetic extension strength on the noninvolved side as well as an association ( r = 0.52, P < .001) for the involved side. Regression analysis showed that in addition to jump height (beta = 0.49, P < .001), sex (beta = –0.17, P = .008) and body mass index (beta = 0.37, P < .001) affected isokinetic strength. The final model explained 51.1% of the variance in isokinetic muscle strength, with jump height having the strongest impact (beta = 0.49, P < .001) and explaining 31.5% of the variance. Conclusion: Initial analysis showed a strong association between isokinetic strength and jump height. The study population encompassed various backgrounds, skill levels, and activity profiles, which might have affected the outcome. Even after controlling for age and sex, isokinetic strength was still moderately associated with jump height. Therefore, the jump technique and type of sport should be considered in future research.
Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia
Authors: Serafin Valentina , Capuzzo Giorgia , Milani Gloria , Minuzzo Sonia Anna , Pinazza Marica , Bortolozzi Roberta , Bresolin Silvia , Porcù Elena , Frasson Chiara , Indraccolo Stefano , Basso Giuseppe , Accordi Benedetta 
Published: November 2017

Key PointsResistance to glucocorticoid treatment in pediatric T-ALL can be reversed by LCK inhibitors in vitro and in vivo. IL-4 overexpression contributes to LCK-induced glucocorticoid resistance.
Review of “DreamMakers: Innovating for the Greater Good” by Michele Hunt, DreamMakers (dreammakers.org)
Authors: Lee Sang 
Published: November 2017

Book detailsHunt, MicheleDreamMakers: Innovating for the Greater Good.Saltaire, UK: Greenleaf Publishing; 2017.200 pages, ISBN13-978-1-78353-568-2
Representation of Minorities and Women in Oncology Clinical Trials: Review of the Past 14 Years
Authors: Duma Narjust , Vera Aguilera Jesus , Paludo Jonas , Haddox Candace L. , Gonzalez Velez Miguel , Wang Yucai , Leventakos Konstantinos , Hubbard Joleen M. , Mansfield Aaron S. , Go Ronald S. , Adjei Alex A. 
Published: November 2017

Purpose: Many cancer clinical trials lack appropriate representation of specific patient populations, limiting their generalizability. Therefore, we determined the representation of ethnic minorities and women in cancer clinical trials. Methods: Enrollment data from all therapeutic trials reported as completed in ClinicalTrials.gov from 2003 to 2016 were analyzed. We calculated enrollment fractions (EFs) for each group, defined as the number of enrollees divided by the 2013 Surveillance, Epidemiology, and End Results (SEER) database cancer prevalence. Results: Of 1,012 clinical trials, 310 (31%) reported ethnicity with a total of 55,689 enrollees. Participation varied significantly across ethnic groups. Non-Hispanic whites were more likely to be enrolled in clinical trials (EF, 1.2%) than African Americans (EF, 0.7%; P < .001) and Hispanics (EF, 0.4%; P < .001). A decrease in African American (6% v 9.2%) and Hispanic (2.6% v 3.1%) enrollment was observed when compared with historical data from 1996 to 2002. Younger patients (age younger than 65 years) were more likely to be enrolled in clinical trials than the elderly (64% v 36%; P < .001). Low recruitment of female patients was observed in clinical trials for melanoma (35%), lung cancer (39%), and pancreatic cancer (40%). Conclusion: We observed a decrease in recruitment of minorities over the past 14 years compared with historical data. African Americans, Hispanics, and women were less likely to be enrolled in cancer clinical trials. Future trials should take extra measures to recruit participants that adequately represent the US cancer population.
Neuroprotective Effects of Fasudil, a Rho-Kinase Inhibitor, After Spinal Cord Ischemia and Reperfusion in Rats
Authors: Ohbuchi Masahiko , Kimura Tetsu , Nishikawa Toshiaki , Horiguchi Takashi , Fukuda Masayuki , Masaki Yoko 
Published: November 2017

BACKGROUND:
Excessive Rho/Rho-kinase pathway activation occurs subsequent to stroke. We examined the neuroprotective effects of pre- and posttreatment with fasudil (a Rho-kinase inhibitor) in a rat transient spinal cord ischemia-reperfusion model under normothermic conditions.

METHODS:
After approval by our animal research committee, male Sprague-Dawley rats were assigned to 1 of 6 groups: pre- and postcontrol (C); pre- and postfasudil (F); and pre- and postsham (S). Fasudil (10 mg/kg) or normal saline was administered intravenously over 30 minutes before ischemia in the pre-F or pre-C groups, and over 30 minutes after reperfusion in the post-F or post-C groups. Sham groups were not subjected to ischemia. Ischemia was induced by aortic occlusion using a balloon catheter combined with hypotension for 10 minutes. Neurologic deficit scores (NDS; 0–8 points) were assessed 1, 7, and 14 days after ischemia, and then histopathologic outcomes were assessed.

RESULTS:
NDS 7 and 14 days after ischemia in the pre-F group (median [range]; 3.5 [2–6] and 2.5 [0–6]) were lower than those in the pre-C group (5.5 [4–7] and 4.5 [4–6]; P = .046 and P = .049), whereas NDS in the post-F group and in the post-C group were not different. The numbers of intact neurons in the gray matter in the pre- and post-F groups (mean ± standard deviation [95% confidence interval]: 25 ± 7 [20–30] and 16 ± 5 [12–19]) were greater than those in the pre- and post-C groups (11 ± 5 [7–14] and 9 ± 3 [7–11]; P < .001 and P = .002). The number of intact neurons in the post-F group (16 ± 5 [12–19]) was lower than the number in the post-S group (26 ± 2 [24–29]; P < .001). The percentages of vacuolation in the white matter in the pre- and post-F groups (21.5 ± 8.4 [15.5–27.5] and 13.6 ± 7.4 [8.3–18.9]) were lower than those in the pre- and post-C groups (43.7 ± 10.4 [36.3–51.1] and 40.6 ± 12.3 [31.8–49.4]; P < .001 and P < .001).

CONCLUSIONS:
Our results demonstrated that intravenous fasudil administered before ischemia improved both neurologic and histopathologic outcomes even 14 days after ischemia, while fasudil administered postinsult improved histopathologic outcomes only in normothermic rats. Fasudil may be a relevant pretreatment paradigm for planned procedures at risk for spinal cord ischemia.
Metabolic and molecular responses to calcium soap of fish oil fed to ewes during peripartal period
Authors: Sheibani S. , Mohammadi-Sangcheshmeh A. , Alamouti A. A. , Khadem A. A. , Norouzian M. A. 
Published: November 2017

It has been shown that n-3 long chain fatty acids (n-3 LCFA) are involved in energy/lipid metabolisms, reproductive parameters, and molecular regulations leading to maintained homeostasis. We hypothesized that supplementation of peripartal diets with fish oil (FO), as a source of n-3 LCFA, could improve energy balance and modulate metabolic pressure in a sheep model. Prepartum ewes (n = 24) were fed control (CON) or calcium soap of fish oil (FO) supplemented-diet from four weeks before until three weeks after parturation. Feed intake, body weight (BW) change, plasma metabolites, colostrums/milk composition, and fatty acids profile of milk along with the expression of core microRNAs in glucose and lipid metabolism were evaluated. Prepartal feed intake decreased in FO group (1674 ± 33.26 vs. 1812 ± 35.56) though post-partal intake was similar. Differences in BW were not also significant (55.47 ± 2.07 in CON vs. 53.69 ± 1.94 in FO). No differences were observed in plasma metabolites except for cholesterol that was lower in FO group (56.25 ± 0.71 vs. 53.09 ± 0.61). Milk fat percentage was reduced (8.82 ± 0.49 vs. 7.03 ± 0.45) while the percentage of milk total n-3 LCFA increased in FO group. In accordance, the relative transcript abundance of miR-101 (0.215 ± 0.08) and miR-103 (0.37 ± 0.15) decreased by FO supplementation. Results showed that FO supplementation during peripartal period decreased milk fat, feed intake, plasma cholesterol, milk n-6:n-3 ratio and the expression of miR-101. Although the trend indicated that FO could alter lipid metabolism during transition period, further studies are needed to fully address its effect on energy balance and homeorhetic processes.
HMGCR and ApoE mutations may cause different responses to lipid lowering statin therapy
Authors: Kirac D. , Bayam E. , Dagdelen M. , Gezmis H. , Sarikaya S. , Pala S. , Altunok E. C. , Genc E. 
Published: November 2017

Coronary artery disease (CAD) and its complications are the major causes of death in the world. Although statins have been used to lower lipid levels in CAD patients, this goal can not be attained in 1/3 of the patients. The objective of this study was to investigate whether common variations in HMG-CoA Reductase(HMGCR) and Apolipoprotein E (ApoE) genes involved in lipid and statin metabolism modify the effect of statins on serum lipid and lipoprotein concentrations in CAD patients.A hundred CAD patients were enrolled into the study. At the beginning of the study biochemical measurements were performed to determine the baseline levels performed. Patients were treated with 40 mg atorvastatin for 2 months and biochemical measurements were repeated. According to the post-treatment, LDL-c levels, patients were divided into 2 groups as non-responders and responders, respectively. The information regarding the risk factors such as smoking, alcohol consumption etc. were also obtained. DNA was isolated from peripheral blood. The presence of rs17244841 ve rs17238540 mutations in HMGCR and Îµ2, Îµ3 and Îµ4 variants of ApoE were determined by using RT-PCR. Results were evaluated statistically. HMGCR mutatations were mostly found in responders and Îµ4 variant of ApoE was mostly found in non-responders. It was also found that presence of HMGCR mutations causes a significant reduction in total cholesterol and LDL-c levels. Also presence of Îµ2 variant of ApoE causes a statistically significant increase in trigliseride levels. Our findings should be investigated with other researchers to clarify the mechanism.