bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoeconomic analysis of rituximab and belimumab therapy in patients with systemic lupus erythematosus
Authors: Gerasimova D. A. , Gontarenko V. A. , Gerasimova E. V. , Zakharova O. V. , Lobuteva L. А. , Popkova T. V. , Lila A. M. 
Published: October 2024

The progressive course of systemic lupus erythematosus (SLE) with high activity and severe internal organs involvement requires the prescription of expensive biologic disease-modifying antirheumatic drugs (bDMARDs), rituximab (RTM) and belimumab (BLM), whose comparative clinical and economic efficacy has not been adequately studied.Objective: to evaluate the clinical and economic efficacy of RTM and BLM therapy in patients with SLE.Material and methods. The study included 50 SLE patients who were divided into two groups and received RTM (group 1, n=25) or BLM (group 2, n=25) therapy for 12 months. The clinical and economic analysis was performed with the cost-effectiveness method using the cost-per-responder (CPR) model. A clinically significant improvement in SLEDAI-2K (Systemic Lupus Erythematosus Disease Activity Index modified 2K; Δ ≥4) was considered a response to therapy. Direct and indirect costs were considered in the analysis.Results and discussion. Against a background of therapy, there was a decrease in SLE activity with a decrease in median SLEDAI-2K in group 1 from 12 [10.5; 18] to 8 [4; 10] and in group 2 from 10 [8; 14.5] to 4 [2; 4] (p< 0.001 in both cases). A clinically significant improvement was observed in 56% of patients in group 1 and 72% of patients in group 2. The peculiarities of the BLM dosing regimen caused higher (1.7 times) total costs than in the case of RTM. According to the CPR value, RTM showed a greater benefit (1.3 times) than BLM (954 thousand rubles versus 1.25 million rubles). The incremental cost-effectiveness ratio (ICER) was 1.4 million rubles, which does not exceed the threshold of willingness to pay for a domestic patient.Conclusion. When comparing BLM and RTM therapy for SLE patients in real-life clinical practice, greater clinical and economic efficiency was demonstrated for RTM. BLM therapy was found to be “cost-effective”.
Ultrasonography of the salivary glands in Sjögren's disease: own data analysis
Authors: Khvan Yu. I. , Torgashina A. V. , Volkov A. V. , Glukhov S. I. 
Published: October 2024

Objective: to investigate feasibility of using ultrasonography (US) to evaluate structural changes of salivary glands (SG) in patients with Sjögren's disease (SD).Material and methods. The study included 159 patients who were examined in V.A. Nasonova Research Institute of Rheumatology from 2016 to 2022 who met V.A. Nasonova Research Institute of Rheumatology 2001, and/or ACR 2012, and/or ACR/EULAR 2016 criteria for SD, and who had not previously received immunosuppressive therapy. All patients underwent a comprehensive classical examination (ophthalmological, dental, immunological) to diagnose SD. Disease activity was determined using ESSDAI index. US of the parotid gland (PG) and submandibular SGs was performed using a GE LOGIQ 9 device, and the images obtained were scored according to the OMERACT SGUS scoring system (SGUS SS).Results and discussion. All SGUS SS scores statistically significantly correlated (p<0.05) with mouth sicca symptoms, enlargement of PG, ESSDAI activity index, presence of lymphohistiocytic infiltrate and focus score in labial SG biopsy, and parenchymatous parotitis according to sialography. No significant correlation was found with the results of sialometry. There was a significant correlation between the changes detected by US and sialography (r=0.422; p=0.001). Considering the data obtained, the consistency of the results of the different examination methods was analyzed. Bland-Altman diagrams were created to reflect the dependence of the differences between the results of US and sialography. At various stages of the comparison, not all data points were within the standardized range. In addition, 5% of the parameters were not within the interval of two standard deviations. The Bland-Altman analysis revealed a systematic discrepancy indicating a low degree of agreement between the two methods for determining structural changes in SG. According to the ROC analysis, sensitivity of ultrasound was 94% and specificity 51%. The area under the curve (AUC) was 0.787 (95% confidence interval 0.700–0.875).Conclusion. SG US and sialography are not interchangeable, but complement each other in the assessment of SG structure. SG US is a safer and non-invasive method of SG examination that does not require contrast agent administration and is likely to play an important role in the dynamic monitoring of patients during the therapy. However, sialography is a more accurate method of diagnostics and assessment of the extent of SG lesions.
Clinical features of vascular cognitive impairment
Authors: Martynova O. O. , Vakhnina N. V. , Zakharov V. V. 
Published: October 2024

Vascular cognitive impairment (VCI) can occur in cerebrovascular disease of varying degree of severity, which requires further investigation.Objective: to identify specific features of attention deficit and executive function (EF) impairment in VCI and to determine the relationship between cognitive, neurological and radiological signs of the disease.Material and methods. The study involved 80 patients (51 with VCI – the main group and 29 healthy volunteers – the control group). All participants underwent clinical and neuropsychological examination and MRI of the brain. VCI was diagnosed according to 2014 VASCOG criteria. The neuropsychological examination included an assessment of the general cognitive function (MoCA test, MMSE); general EF (FAB, EXIT-25); episodic memory (12-word memory test and Benton Visual Retention Test); semantic memory (categorical association method); initiation and productivity of cognitive activity (literal associations); attention [TMT-A, Symbol-Digit Modalities Test (SDMT)]; cognitive flexibility (TMT-B); cognitive control (Stroop test).Results. As a result of the study, three subgroups of patients with VCI were identified: 1) predominantly attention deficit (AD); 2) AD and significant decrease in cognitive flexibility (CFD); 3) AD in combination with a significant cognitive control deficiency (CCD). The TMT-A and SDMT tests were significantly worse in all subgroups of VCI compared to the control group, with the worst SDMT score in subgroup 2. Subgroup 2 also had the longest time to complete the TMT-B test. Subgroup 3 was characterized by the worst Stroop test results, and uncontrolled arterial hypertension was more common in this group. Gait disturbances were significantly more frequent in subgroup 2, and increased reflexes of oral automatism and grasp reflex were observed in subgroup 3. White matter hyperintensity (WMH) was more pronounced in subgroup 2, and lacunar infarcts (LI) were more frequent in subgroup 3. Prevalence of LI and severity of WMH were lowest in subgroup 1.Conclusion. The main features of VCI are attention deficit and EF impairment, characteristics of EF disorders depend on the severity and type of vascular lesions of the brain. Progression of WMH is associated with more pronounced CFD and an increase in the number of LI is associated with CCD. There is a correlation between CFD and gait disturbances and between CCD and lack of primitive reflexes inhibition.
Asthenia and vascular cognitive impairment in young patients after stroke
Authors: Shchepankevich L. A. , Rerikh K. V. , Ponomareva M. S. , Zatynko A. V. , Taneeva E. V. 
Published: October 2024

Post-stroke cognitive impairment (PSCI) is found in most patients over 50 years of age. At a young age, PSCI has a negative impact on daily activities, quality of life and return to work, regardless of physical recovery. Often PSCI are combined with asthenia, but there is very little information on the prevalence of post-stroke asthenia (PSA). Currently, the treatment of PSCI and PSA in young patients with citicoline is still controversial.Objective: to evaluate the prevalence of PSCI and PSA in young patients and the efficacy and safety of the domestic drug Noocil (citicoline) in the treatment of PSCI and PSA in stroke patients of young age.Material and methods. The work was conducted in two stages: the first stage was a longitudinal study of cognitive status using neurocognitive scales and assessment of signs of asthenia in patients aged 18 to 45 years; the second stage was an open prospective observational study of 47 patients aged 18 to 45 years with confirmed ischemic stroke (IS) who were randomly assigned to groups with Noocil administration (main group; n=26) or without treatment (control group; n=21). Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) and asthenia by manifestations of general fatigue (Multidimensional Fatigue Inventory, MFI-20).Results. High frequency of PSCI (51%) and the severity of asthenia according to MFI-20 scale were found in the hospital sample of young patients with IS. A direct correlation was found between the severity of PSA and the degree of cognitive decline. The positive effect of Noozil on cognitive functions, emotional state and severity of asthenia in the study group was noted. At the end of treatment, the mean MoCA score was 27.4±1.4 in the main group and 25.9±1.1 in the control group (p<0.01), and the mean MFI-20 score was 37.4±7.4 in the main group and 43.7±5.1 in the control group (p<0.01).Conclusion. The high incidence of PSCI and PSA and the positive effect of Noocil on the non-motor consequences of stroke in young patients and the high safety profile of the drug were shown.
Ischemic stroke due to dissection of the posterior cerebral artery in a patient with polycystic kidney disease
Authors: Maksimova M. Yu. , Airapetova A. S. 
Published: October 2024

Polycystic kidney disease (PKD) is a genetic condition clinically manifested by the formation of multiple cysts in the kidneys, liver and pancreas, as well as cardiovascular pathology. One of the rare complications of PKD is the development of dissections of the aorta, coronary and cerebral arteries.This article presents a clinical case of ischemic stroke due to dissection of the posterior cerebral artery in a young patient with PKD who had a history of recurrent bleeding in the deep parts of both cerebral hemispheres.
Typical tactics of treatment of patients with chronic non-specific back pain and tension-type headaches
Authors: Golovacheva A. A. , Golovacheva V. A. 
Published: October 2024

Non-specific (musculoskeletal) back pain (NBP) and tension-type headache (THA) are among the most common conditions in neurological practice that significantly impair patients' ability to work. The typical practice of treating patients with NBP and THA has not been sufficiently investigated, which formed the basis for conducting this study.Objective: to evaluate the quality of diagnosis and treatment of chronic NBP and THA in real-life neurological practice.Material and methods. The study included 120 patients with chronic NBP and combined THA of different frequency (32 men and 88 women, mean age 38.4±9.6 years) who were treated in A.Ya. Kozhevnikov Clinic of Neurologic Diseases (CND) of Sechenov University with complaints of back pain and headache and who had previously been examined and treated by neurologists and therapists in other medical institutions on an outpatient and/or inpatient basis. All patients underwent a clinical interview to establish a diagnosis and analyze previous treatment, a neurological and neuro-orthopedic examination and a psychometric examination to assess anxiety and depression symptoms.Results. Prior to contacting CND, only 10% of patients had a diagnosis of chronic NBS, only 7% had a diagnosis of THA and the remaining patients had other misdiagnoses. All patients had previously undergone additional examinations, mainly neuroimaging of the spine and brain, ultrasound examination of the neck vessels, even if there were no "red flags" – signs of danger in back pain and headache. None of the patients had previously had their emotional state assessed, while 75% of patients had symptoms of depression of varying severity and all patients suffered from anxiety of varying severity. Neuro-orthopaedic examination was performed in only 10% of patients. All patients received nonsteroidal antiinflammatory drugs for back pain, and most patients received vascular and nootropic medication for headaches. Of the non-pharmacological methods, massage and passive physiotherapy were most frequently prescribed. Only 9% of patients were recommended kinesiotherapy, and only 5% of patients performed it.Conclusion. In real-life medical practice, chronic NBP and THA are inadequately diagnosed, excessive and unjustified additional examinations are prescribed, unsatisfactory level of treatment, and patients with chronic NBP and THA are rarely prescribed kinesiotherapy.
PERAN KANDUNGAN ZAT GIZI DAN SENYAWA BIOAKTIF PISANG TERHADAP TINGKAT NAFSU MAKAN : A LITERATURE REVIEW
Authors: Basaria Pakpahan Santi , Anjani Gemala , Pramono Adriyan 
Published: October 2024

ABSTRACTBioactive compounds can be found in various types of plants and fruit with various biological benefits, such as anti-inflammatory, antioxidant, anti-cancer, anti-obesity and anti-diabetic which have the potential to prevent various chronic diseases. Currently, several studies have proven the effect of consuming fruits on serum levels of satiety and appetite hormones, as well as degree of satiety based on visual analogie scale (VAS). However there is still limited study on the effect of bananas bioactive compound on satiety and appetite. There are several bioactive compounds in bananas, including polyphenol, flavonoids, phenol, phenolic and anthocyanin, of which act as antioxidants. Furthermore Bananas also contain of complex carbohydrates as a source of fiber in which mayhave an effect on satiety and appetite. The complex carbohydrate and antioxidants of bioactive compounds have been suggested to play roles on the regulatuion of appetite and satiety through the modulation of the gut hormones. The purpose of this narrative review is to overview the various bioactive compounds and the complex carbohydrate in bananas as well as providing a summary of the biological mechanisms related to the regulation of satiety hormones and appetite levels.Keywords : Banana; bioactive compounds; satiety hormones; appetite leves ABSTRAKSenyawa bioaktif dapat ditemukan pada berbagai jenis tanaman dan buah-buahan dengan berbagai manfaat biologis, seperti antiinflamasi, antioksidan, antikanker, antiobesitas dan antidiabetik yang berpotensi dalam pencegahan terhadap berbagai penyakit kronis. Saat ini, beberapa penelitian telah membuktikan adanya pengaruh konsumsi buah-buahan terhadap kadar serum hormon kenyang dan nafsu makan serta tingkat rasa kenyang berdasarkan pengukuran visual analogue scale (VAS), namun masih terbatas yang meneliti pada pisang. Beberapa senyawa bioaktif pada pisang diantaranya, polifenol, flavonoid, fenol, fenolik dan antosianin bersifat sebagai antioksidan. Pisang sebagian besar mengandung karbohidrat komples sebagai sumber serat dan berbagai senyawa bioaktif yang dapat memberikan pengaruh terhadap rasa kenyang dan tingkat nafsu makan. Karbohidrat kompleks dan senyawa bioaktif diduga berperan dalam pengaturan nafsu makan dan rasa kenyang melalui modulasi satiety hormones. Tujuan dari tinjauan naratif ini adalah untuk meninjau berbagai senyawa bioaktif dalam pisang serta memberikan ringkasan mekanisme biologis terkait pengaturan hormon kenyang dan tingkat nafsu makan. Kata Kunci : Pisang; senyawa bioaktif; hormon kenyang; tingkat nafsu makan
The Suspense of Envy
Authors: von Sass Hartmut 
Published: October 2024

Abstract
My basic question in this paper is pretty straightforward: which resources does the Christian tradition have to overcome envy? If one reads the story of Christ’s passion as an “envy drama” and Christ’s cross as the unjust result of his enemies’ sinful envy (see Mk 15:10), one might offer a more elaborate version of the initial question: what do the crucifixion and resurrection mean when reconsidered as overcoming – or, as I shall say: suspending – envy as cardinal sin? Section one lays out conceptual issues, while section two repudiates two attempts of defending a particular form of envy. Section three is dedicated to different soteriological and Christological models in asking how they can deal with sin (and envy). It reacts to the problems implied by these accounts, particularly the subjectivist one, by suggesting a praxeological answer to the question of this paper.
Analysis of agricultural emissions and economic growth in Europe in search of ecological balance
Authors: Georgieva Vanya 
Published: October 2024

Abstract
This study analyses the relationship between economic growth, measured by gross value added in agriculture, and greenhouse gas emissions from the sector in 30 European countries during the period 2012–2021. The aim is to assess whether the increase in agricultural production leads to a corresponding increase in harmful emissions. Regression analysis is applied to establish linear statistical dependencies between variables, cluster analysis to group countries, and analysis of trends in the dynamics of indicators. The results show significant differences between countries, with no universal relationship between economic growth and emissions. A “decoupling” between growth and emissions is observed in some countries, demonstrating the potential for “green growth.” Regional and structural differences, as well as the level of technological development, stand out as key factors determining the relationship between economic growth and emissions, highlighting the need for an individualised approach in formulating policies for the sustainable development of the agricultural sector.
Vertical larynx actions and intergestural timing stability in Hausa ejectives and implosives
Authors: Oh Miran , Byrd Dani , Goldstein Louis , Narayanan Shrikanth S. 
Published: October 2024

Abstract
The current project undertakes a kinematic examination of vertical larynx actions and intergestural timing stability within multi-gesture complex segments such as ejectives and implosives that may possess specific temporal goals critical to their articulatory realization. Using real-time MRI (rtMRI) speech production data from Hausa non-pulmonic and pulmonic consonants, this study illuminates speech timing between oral constriction and vertical larynx actions within segments and the role this intergestural timing plays in realizing phonological contrasts and processes in varying prosodic contexts. Results suggest that vertical larynx actions have greater magnitude in the production of ejectives compared to their pulmonic counterparts, but implosives and pulmonic consonants are differentiated not by vertical larynx magnitude but by the intergestural timing patterns between their oral and vertical larynx gestures. Moreover, intergestural timing stability/variability between oral and non-oral (vertical larynx) actions differ among ejectives, implosives, and pulmonic consonants, with ejectives having the most stable temporal lags, followed by implosives and pulmonic consonants, respectively. Lastly, the findings show how contrastive linguistic ‘molecules’ – here, segment-sized phonological complexes with multiple gestures – interact with phrasal context in speech in such a way that it variably shapes temporal organization between participating gestures as well as respecting stability in relative timing between such gestures comprising a segment.
Missed encounters: what may be relevant for an AI is not for a human being
Authors: Silvestri Filippo 
Published: October 2024

Abstract
The World Wide Web has been a fundamental part of our daily lives for years. Its algorithmic framework ensnares our online journeys in an “endless recurrence” of the “same” by creating multiple filter bubbles. Digital algorithms establish a precise “order of discourse,” leaving little to no room for deviation. Functioning as a colossal machinic apparatus, the web embodies the culmination of Artificial Intelligence (AI), transforming every piece of posted content into a database that profiles our online behavior and activities. This article explores whether approaches that describe everyday human communication, such as the theories of relevance developed by Alfred Schutz, or by Dan Sperber and Deirdre Wilson, can be applied to the realm of digital algorithmic grammars governing the web, and to the semiospheres that animate it. The conclusions raise some doubts: a gap exists between algorithmic language and its historical counterparts, characterized by a disparity between logical-mathematical grammar and other linguistic-historical-natural ones. While these two types of languages coexist within the digital landscape, their relevance differs; what may be “relevant” in an algebraic context may not necessarily translate to our live conversational exchanges, and vice versa. Although merged in the digital sphere, these languages operate distinctly, and proficiency in one does not guarantee adeptness in interpreting the other accurately.
Calcinosis around the joints of hands and arteries
Authors: S. Chandrashekara  
Published: October 2024

Calcinosis is an unusual tissue response seen in certain connective tissue diseases. It usually occurs in subcutaneous tissues, and the involvement of arteries and their walls is less common. The figure 1 shows the hand X- ray of a 38-year-old female patient with limited systemic sclerosis. The patient was diagnosed around 10 years ago.
The Relationship Between Islam and Local Wisdom in the Kampung Naga Tradition: Living Sunnah Research
Authors: Darmalaksana Wahyudin , Ratnasih Teti , Nur Saifudin 
Published: October 2024

This study aims to analyze the values of the hadith of the Prophet who lived in the Kampung Naga tradition. This study applies a qualitative approach with a descriptive-analytical method through a field study based on the interpretation of the living sunnah. The results and discussion of this study found that the living sunnah in the Kampung Naga tradition lies in the rituals of pregnant women, birth of children, circumcision, gusaran, marriage, inheritance, blessings, death prayers, Hajat Sasih after Eid prayer, and others. The study concludes that the living sunnah is relevant to be applied considering that the Kampung Naga tradition is a crystallization of Islam and Sundanese local wisdom as an ancestral heritage. Living sunnah is able to explore the values of hadith that live in the Kampung Naga tradition without syncretic stigmatization of rituals that are considered incompatible with Islamic law. This study recommends further research maximally by compiling the research themes of living sunnah in the Kampung Naga tradition.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//