bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Intra- and Extra-Articular Technique in Revision Anterior Cruciate Ligament Reconstruction
Authors: Zanovello Jessica , Rosso Federica , Bistolfi Alessandro , Rossi Roberto , Castoldi Filippo 
Published: August 2017

Purpose The aim of the study was to evaluate the “over the top” (OTT) nonanatomical technique for revision of anterior cruciate ligament (ACL) reconstruction.
Methods Twenty-four patients with a mean age of 31.9 ± 11.2 years underwent revision of ACL reconstruction using OTT technique. International Knee Documentation Committee (IKDC) score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Lysholm score, Tegner score, Subjective Patient Outcome for Return to Sport (SPORTS) score, Anterior Cruciate Ligament-Return to Sport After Injury (ACL-RSI) scale, and KT-1000 evaluation were recorded at a mean follow-up of 30.7 ± 18.9 months.
Results Postoperatively, the IKDC objective total score significantly improved (p = 0.0046). The KOOS, Lysholm, and Tegner scores also improved, but the results were not statistically significant (62.4 vs. 72.6, 6.5 vs. 75.8, and 4.1 vs. 6.0, respectively). The subjective IKDC evaluation score improved from an average of 51.1 points to 63.7 points at the last follow-up (p = 0.0027). The RTP prevalence was 81.8%, with 44.4% of the patients returning to the same preinjury level. According to the SPORTS score, 16.6% of patients played sport without limitations in activity and performance. The average ACL-RSI score was 52.1 ± 27.0. No major complications were reported. A total of 21.5% of patients underwent surgical removal of staples. The failure prevalence was 14.3% and the cumulative survivorship, calculated using the Kaplan–Meier method, was equal to 70% at 60 months of follow-up.
Conclusion The OTT technique in the revision ACL reconstruction provided improvement in objective and subjective scores, good RTP prevalence, and acceptable rate of complication and failure. One of the advantages was the possibility to avoid the femoral tunnel.
Level of Evidence Level IV, therapeutic case series.
“Drink before breakfast and vomit”
Authors: Niedenthal Tobias , Mayer Johannes 
Published: August 2017

ZusammenfassungDie Wiederentdeckung Amerikas brachte uns Europäern einige heute sehr bekannte Arzneipflanzen, darunter die Kapuzinerkresse (Tropaeolum majus L., Arzneipflanze des Jahres 2013), die Passionsblume (Passiflora incarnata L., Arzneipflanze des Jahres 2011), die Sägepalme (Serenoa repens [W.Bartram] Small), den Purpur-Sonnenhut (Echinacea purpurea [L.] Moench) und auch die Virginische Zaubernuss (Hamamelis virginiana L.). Da die Zaubernuss sich bereits früh bei den europäischen Siedlern größerer Beliebtheit erfreute, lässt sich hier sehr gut die Übernahme der traditionellen Verwendung bei den Ureinwohnern sowie die sich entwickelnde kommerzielle Vermarktung und wissenschaftliche Erforschung im 19. Jahrhundert nachzeichnen. Ebenso sind der Sprung nach Europa ab den 1870er-Jahren und nachfolgende Entwicklungen gut zu verfolgen.
Der N. trigeminus in der osteopathischen Praxis
Authors: Schendel Linda 
Published: August 2017

ZusammenfassungDer N. trigeminus ist der 5. und dickste der Hirnnerven. Durch seine zahlreichen sensiblen sowie motorischen Fasern wird ihm eine große
Bedeutung in der osteopathischen Praxis zuteil. Im Verlauf seiner 3 Äste können zahlreiche Dysfunktionen entstehen, für deren Behandlung die
kraniosakrale Osteopathie einige Techniken bereithält. Folgender Artikel soll einen Überblick über Anatomie, Dysfunktionen und mögliche
Behandlungsoptionen geben.
Philosophie und ihre Bedeutung für die Osteopathie?
Authors: Ingenfeld Martin 
Published: August 2017

ZusammenfassungDie Osteopathie steht seit ihrer Entstehung in einem engen Zusammenhang zu einer an der Philosophie orientierten kritischen Selbstreflexion
wie auch zum medizinischen und wissenschaftlichen Erkenntnisstand ihrer Zeit. Die andauernde Vertrauenskrise des Gesundheitswesens, aber
auch der dramatische Erkenntnisfortschritt in der naturwissenschaftlich fundierten Medizin sollten Anlass sein, diese Auseinandersetzungen
selbstbewusst fortzuführen – ohne die eigenen Wurzeln zu verleugnen, aber auch ohne unüberlegte Abgrenzungen.
Typologies of knowledge: a reexamination from the perspective of cognitive materialism
Authors: Zukerfeld Mariano 
Published: August 2017

AbstractThe aim of this paper is to reexamine some typologies of knowledge as a means of framing the presentation of our own typology, which arises from a particular theoretical framework – cognitive materialism. In a somewhat arbitrary route through the economics of innovation, organizational and management studies, the typologies of Lundvall, Machlup, Mokyr, Spender, Blackler and Chartrand are reviewed and criticized. Then, picking up on some elements which arise from the previous analysis, the proposal of a cognitive materialist typology is introduced, based on distinguishing types of knowledge on the basis of the material medium or bearer in which they exist. A division into four types is suggested: knowledge with a biological, subjective, inter-subjective and objective bearer, each with its own respective sub-types.
Growth of Solutions to NLS on Irrational Tori
Authors: Deng Yu , Germain Pierre 
Published: August 2017

Abstract
We prove polynomial bounds on the $H^s$ growth for the nonlinear Schrödinger equation set on a torus, in dimension 3, with super-cubic and sub-quintic nonlinearity. Due to improved Strichartz estimates, these bounds are better for irrational tori than they are for rational tori.
Case-based review: pediatric medulloblastoma
Authors: Kline Cassie N , Packer Roger J , Hwang Eugene I , Raleigh David R , Braunstein Steve , Raffel Corey , Bandopadhayay Pratiti , Solomon David A , Aboian Mariam , Cha Soonmee , Mueller Sabine 
Published: August 2017

AbstractMedulloblastoma is the most common malignant brain tumor affecting children. These tumors are high grade with propensity to metastasize within the central nervous system and, less frequently, outside the neuraxis. Recent advancements in molecular subgrouping of medulloblastoma refine diagnosis and improve counseling in regards to overall prognosis. Both are predicated on the molecular drivers of each subgroup—WNT-activated, SHH-activated, group 3, and group 4. The traditional therapeutic mainstay for medulloblastoma includes a multimodal approach with surgery, radiation, and multiagent chemotherapy. As we discover more about the molecular basis of medulloblastoma, efforts to adjust treatment approaches based on molecular risk stratification are under active investigation. Certainly, the known neurological, developmental, endocrine, and psychosocial injury related to medulloblastoma and its associated therapies motivate ongoing research towards improving treatment for this life-threatening tumor while at the same time minimizing long-term side effects.
Diagnosing and managing scleroderma-related pulmonary arterial hypertension
Authors: Athanasiou Katherine Alexis , Sahni Sonu , Rana Amrinder , Talwar Arunabh 
Published: August 2017

ABSTRACT
Scleroderma is an uncommon autoimmune disease of unknown cause that may affect any organ system in the body. Patients with scleroderma are prone to developing pulmonary complications, including pulmonary arterial hypertension (PAH), that are the leading cause of death in this population. This article describes scleroderma-related PAH and its diagnosis and management.
The roles of dermal white adipose tissue loss in scleroderma skin fibrosis
Authors: Marangoni Roberta G. , Lu Theresa T. 
Published: August 2017

Purpose of review
Dermal white adipose tissue (DWAT) is distinct from subcutaneous white adipose tissue and is lost in scleroderma skin fibrosis. The roles of DWAT loss in scleroderma skin fibrosis have not been well understood, and here we discuss recent findings that begin to provide insight into the multiple mechanisms involved.

Recent findings
The DWAT loss in part reflects the direct contribution of DWAT cells to the fibrotic tissue, with the reprogramming of adipocytes to myofibroblasts. The DWAT contains reparative adipose-derived stromal cells and expresses antifibrotic cytokines such as adiponectin, and the loss of these skin-protective mechanisms with DWAT loss further contributes to skin fibrosis and injury.

Summary
Potentially, halting or reversing the transdifferentiation of adipocytes to myofibroblasts along with improving survival of reparative adipose-derived stromal cells (ADSCs) and expression of antifibrotic cytokines may be effective therapeutic avenues.
Intimate Partner Violence Victimization and Associated Implications for Health and Functioning Among Male and Female Post-9/11 Veterans
Authors: Iverson Katherine M. , Vogt Dawne , Maskin Rachel M. , Smith Brian N. 
Published: August 2017

Background:
There is increased emphasis on identifying patients who experience intimate partner violence (IPV) in Department of Veterans Affairs and other health care settings. A better understanding of IPV’s implications for health and functioning is needed among post-911 Veterans, and especially male Veterans, to inform IPV screening and response.

Objectives:
To identify past 6-month IPV experienced among partnered post-9/11 Veterans and examine sex-based associations between IPV and health.

Research Design:
A national sample of Veterans completed a survey that included measures of IPV victimization and health. Types of IPV and relationships with health and functioning were examined separately for male and female Veterans.

Subjects:
In total, 407 post-9/11 Veterans (52% women) in intimate relationships.

Measures:
IPV victimization was assessed with the Conflict Tactics Scales-Revised. Health and functioning indicators included posttraumatic stress disorder (PCL-5) and depression (Beck Depression Inventory-Primary Care) symptoms, physical health–related quality of life (Short-Form 12-item Health Survey), and occupational functioning (Inventory of Psychosocial Functioning).

Results:
Nearly two thirds of both men and women reported past 6-month IPV, with greatest endorsement of psychological aggression (65% of men, 59% of women). A total of 8% of men and 7% of women reported physical IPV and 4% of men and 7% of women reported sexual IPV. Psychological aggression was strongly linked with mental health for both sexes and greater occupational impairment for men. Physical and sexual IPV were associated with more severe mental health symptoms for women while physical IPV was negatively associated with physical health–related quality of life for men.

Conclusions:
Recent IPV victimization, especially psychological aggression, is a key health issue for partnered male and female post-9/11 Veterans. Practice and research implications are discussed.
Delirium in the Critically Ill Child
Authors: Norman Sharon , Taha Asma A. , Turner Helen N. 
Published: August 2017

Purpose/Objective:
The purposes of this article are to describe the scientific literature on assessment, prevention, and management of delirium in critically ill children and to articulate the implications for clinical nurse specialists, in translating the evidence into practice.

Description:
A literature search was conducted in 4 databases—OvidMEDLINE, Cumulative Index to Nursing and Allied Health Literature, PsychINFO, and Web of Science—using the terms “delirium,” “child,” and “critically ill” for the period of 2006 to 2016.

Outcome:
The scientific literature included articles on diagnosis, prevalence, risk factors, adverse outcomes, screening tools, prevention, and management. The prevalence of delirium in critically ill children is up to 30%. Risk factors include age, developmental delay, severity of illness, and mechanical ventilation. Adverse outcomes include increased mortality, hospital length of stay, and cost for the critically ill child with delirium. Valid and reliable delirium screening tools are available for critically ill children. Prevention and management strategies include interventions to address environmental triggers, sleep disruption, integrated family care, and mobilization.

Conclusion:
Delirium is a common occurrence for the critically ill child. The clinical nurse specialist is accountable for leading the implementation of practice changes that are based on evidence to improve patient outcomes. Screening and early intervention for delirium are key to mitigating adverse outcomes for critically ill children.
Reported Cases of Neurosyphilis Among Early Syphilis Cases—United States, 2009 to 2015
Authors: de Voux Alex , Kidd Sarah , Torrone Elizabeth A. 
Published: August 2017

Abstract
The surveillance of neurosyphilis, an uncommon but severe consequence of syphilis, is complex; surveillance classification of neurosyphilis requires a lumbar puncture and cerebrospinal fluid analysis. We examined the prevalence of reported neurosyphilis among primary, secondary, and early latent syphilis cases reported in the United States from 2009 to 2015. Overall, the prevalence of reported neurosyphilis from 2009 to 2015 was low (0.84%); however, this is likely an underestimate of the true burden in the United States.
Revisiting the Abdominal Donor Site: Introducing a Novel Nomenclature for Autologous Breast Reconstruction
Authors: Weissler Jason M. , Albino Frank P. , Carney Martin J. , Wu Liza C. 
Published: August 2017

Background:As abdominally based free flaps for breast reconstruction continue to evolve, significant effort has been invested in minimizing donor-site morbidity. The impact on the donor site remains a prevailing principle for breast reconstruction, and thus must be adequately reflected when classifying what is left behind following flap harvest. Although successful in describing the type of flap harvested, the existing nomenclature falls short of incorporating certain critical variables, such as degree of muscular preservation, fascial involvement, mesh implantation, and segmental nerve anatomy.Methods:In an effort to expand on Nahabedian’s 2002 classification system, this descriptive study revisits and critically reviews the existing donor-site classification system following abdominally based breast reconstruction.Results:The authors propose a nomenclature system that emphasizes variability in flap harvest technique, degree of muscular violation, fascial resection, mesh implantation, and degree of nerve transection.Conclusion:With this revised classification system, reconstructive surgeons can begin reporting more clinically relevant and accurate information with regard to donor-site morbidity.
Optimization and Standardization of the Immunodeficient Mouse Model for Assessing Fat Grafting Outcomes
Authors: Kokai Lauren E. , Jones Taraneh L. , Silowash Russell , Theisen Brian , DiBernardo Gabriella , Lu Andrew , Yi Bowen , Marra Kacey G. , Rubin J. Peter 
Published: August 2017

Background:
Animal models are often used to assess interventions that might improve fat grafting outcomes; however, there is great variability in the models. The authors sought to determine the predictive value of the immunocompromised mouse model for fat grafting so that experiments could be standardized and optimized.

Methods:
Human lipoaspirate injections at different volumes and time points were assessed in a nude mouse model and compared with control injections of nonviable fat. Volume retention and explant histologic score were compared. In a separate study, interanimal reproducibility was determined by implanting a highly consistent hydrogel and measuring variability in volume retention.

Results:
Injection volume significantly affects adipose resorption kinetics at 6 and 12 weeks. Masson trichrome staining revealed that macrophages were unable to infiltrate large (1 ml) grafts, and oil cysts were not absorbed by 18 weeks, which interfered with interpretation of volume retention data. Nonviable tissue was resorbed when grafts were 0.3 ml, and quantification of graft histologic viability correlated well with graft retention at all study time points. Interanimal variability was measured to be 8.44 percent of the mean retention volume for small graft volumes.

Conclusions:
Human fat graft retention in the immunodeficient mouse correlates with graft viability in small, 0.3-ml-volume grafts. However, centralized oil cysts in nonviable 1.0-ml grafts were not resorbed by 18 weeks and thus volume measurements were confounded and not significantly different from viable samples. In addition, tissue injury scores increased in initially healthy fat grafts at 18 weeks, possibly because of a delayed immune reaction.
Transient Amaurosis and Diplopia After Inferior Alveolar Nerve Block
Authors: Odabaşi Onur , Şahin Onur , Polat Mehmet Emrah 
Published: August 2017

AbstractA 40-year-old female patient was admitted to the authors’ oral and maxillofacial clinic for removal of her lower left second molar under local anesthesia. The patient's medical history revealed that she had cardiac arhythmia and hypertension. Inferior alveolar nerve block was achieved using 2 mL of sefacaine (%3 mepivacaine HCL, without epinephrine). The patient complained of loss of vision in her left eye. All procedures were stopped immediately. Within 2 minutes the patient reported diplopia. All of the symptoms disappeared about 5 minutes after initial observation. Follow-up after 1 day revealed no complications. The procedure was then performed uneventfully.
Monsters in the uterus: A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-typeC.elegans
Authors: Wang Hongyuan , Zhao Yuan , Ezcurra Marina , Gilliat Ann F. , Hellberg Josephine , Benedetto Alexandre , Athigapanich Trin , Girstmair Johannes , Telford Max , Zhang Zhizhou , Gems David 
Published: August 2017

AbstractMany diseases whose frequency increases with advancing age are caused by aging (senescence), but the mechanisms of senescence remain poorly understood. According to G.C. Williams and M.V. Blagosklonny, a major etiological determinant of senescence is late-life, wild-type gene action and non-adaptive execution of biological programs (or quasi-programs). These generate a wide range of senescent pathologies causing illness and death. Here we investigate the etiology of a prominent senescent pathology in the nematodeC. elegans, uterine tumors, in the light of the Williams Blagosklonny theory. Uterine tumors develop from unfertilized, immature oocytes which execute incomplete embryogenetic programs. This includes extensive endomitosis, leading to formation of chromatin masses and cellular hypertrophy. The starting point of pathogenesis is exhaustion of sperm stocks. The timing of this transition between program and quasi-program can be altered by blocking sperm production (causing earlier tumors) or supplying additional sperm by mating (delaying tumor onset). Other pathophysiological determinants are yolk consumption by tumors, and bacterial proliferation within tumors. Uterine tumors resemble mammalian ovarian teratomas (tera, Greek: monster) in that both develop from oocytes that fail to mature after meiosis I, and both are the result of quasi-programs. Moreover, older but not younger uterine tumors show expression of markers of later embryogenesis, i.e. are teratoma-like. These results show how uterine tumors inC. elegansform as the result of run-on of embryogenetic quasi-programs. They also suggest fundamental etiological equivalence between teratoma and some forms of senescent pathology, insofar as both are caused by quasi-programs.
COGEM: A Toolbox for Computational Genomics in Matlab
Authors: Perkins Theodore J. 
Published: August 2017

AbstractMotivationThe Matlab programming language is widely used for both teaching and research in engineering, computer science, and mathematics. Despite its many strengths, it has never been a dominant language in computational genomics or bioinformatics more generally.ResultsHere, we introduce COGEM, a long-term project to develop computational genomics functionality in Matlab. The initial release provides functions for manipulating genomic intervals, stranded or unstranded, with or without numerical data associated. It includes features for both text and binary file input and output, conversion between BAM, BED and BEDGRAPH formats, and numerous functions for manipulating intervals, including shifting, expanding, overlapping, intersecting, unioning, finding nearest intervals, piling up intervals, and performing unary and binary numerical and logical operations on sets of intervals. The toolbox is well-suited to the analysis of high-throughput sequencing data. We demonstrate its functionality by creating a ChIP-seq peak-calling algorithm by chaining together a series of commands, and find it capable of analyzing genome-scale data in reasonable time.AvailabilityThe current toolbox and reference manual is available as supplementary material, and updated versions will be maintained atwww.perkinslab.caonline.
Does genetic risk help to predict amyloid burden in a non-demented population? A Bayesian approach
Authors: Voyle Nicola , Jansen Willemijn , Keohane Aoife , Patel Hamel , Folarin Amos , Newhouse Stephen , Johnston Caroline , Lin Kuang , Visser Pieter Jelle , Hodges Angela , Dobson Richard JB , Kiddle Steven J ,   for the Alzheimer’s Disease Neuroimaging Initiative,   EDAR and DESCRIPA study groups
Published: August 2017

AbstractINTRODUCTIONIn this study we investigate the association between Aβ levels in cerebrospinal fluid (CSF) and genetic risk in a non-demented population. This paper presents the first analysis to use a Bayesian methodology in this area.METHODSData from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the EDAR* and DESCRIPA** studies was used in a Bayesian logistic regression analysis. We modeled CSF Aβ burden using age, diagnosis (healthy control or mild cognitive impairment), APOE and a polygenic risk score (PGRS) associated with Alzheimer’s Disease (AD). We compared models built using informative priors on age, diagnosis and APOE with non-informative priors on all variables.RESULTSThe use of informative priors did not improve model performance in the majority of cases. Models using only age, diagnosis and APOE genotype showed the best predictive ability.DISCUSSIONA previous study indicated that a PGRS of AD case/control status was associated with CSF Aβ burden in healthy controls. The current study suggests that this association does not lead to models that are more predictive of amyloid positivity than already known factors such as age and APOE.*‘Beta amyloid oligomers in the early diagnosis of AD and as marker for treatment response’**‘Development of screening guidelines and criteria for pre-dementia Alzheimers disease’
Spatially varying cis-regulatory divergence inDrosophilaembryos elucidates cis-regulatory logic
Authors: Combs Peter A. , Fraser Hunter B. 
Published: August 2017

AbstractSpatial patterning of gene expression is a key process in development—responsible for the incredible diversity of animal body plans—yet how it evolves is still poorly understood. Both cis- and trans-acting changes could accumulate and participate in complex interactions, so to isolate the cis-regulatory component of patterning evolution, we measured allele-specific spatial gene expression patterns inD. melanogaster×D. simulanshybrid embryos. RNA-seq of cryosectioned slices revealed 55 genes with strong spatially varying allele-specific expression, and several hundred more with weaker but significant spatial divergence. For example, we found thathunchback (hb), a major regulator of developmental patterning, had reduced expression specifically in the anterior tip ofD. simulansembryos. Mathematical modeling ofhbcis-regulation suggested that a mutation in a Bicoid binding site was responsible, which we verified using CRISPR-Cas9 genome editing. In sum, even comparing morphologically near-identical species we identified a substantial amount of spatial variation in gene expression, suggesting that development is robust to many such changes, but also that natural selection may have ample raw material for evolving new body plans via cis-regulatory divergence.