bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Pelvic Morphology Between Women with and Without Provoked Vestibulodynia
Authors: McLean Linda , Thibault-Gagnon Stephanie , Brooks Kaylee , Goldfinger Corrie , Pukall Caroline , Chamberlain Susan 
Published: May 2016

ABSTRACT

Objective
Pelvic morphology has been suggested to reflect increased tone and reduced strength of the pelvic floor muscles (PFMs) in women with provoked vestibulodynia (PVD) compared to healthy controls. We aimed to determine whether there are differences in pelvic morphology in the resting state, on maximum voluntary contraction (MVC), or on maximum effort Valsalva maneuver (MVM) between women with and without PVD.

Methods
While imaged using ultrasound, 38 women with PVD and 39 controls relaxed their PFMs, performed 3 MVCs and performed 3 MVMs. Levator plate length (LPL), levator plate angle (LPA), and anorectal angle (ARA) were determined at rest, at MVC and at MVM. The displacement of the bladder neck (BN) on MVC and on MVM was also determined. Two-way ANCOVAs were used to evaluate the main effects of group and task, the interaction between group and task, and the effect of resting morphology on LPL, LPA, and ARA. A 2-way repeated-measures ANOVA was used to determine whether the groups differed in terms of BN displacement during the tasks.

Results
Women with PVD had smaller LPLs and LPAs than controls across all tasks. The significant group differences in LPL and LPA at MVC and MVM were no longer significant once the resting values were included as covariates in the models. Bladder neck displacement differed between the groups at MVM but not at MVC.

Conclusion
Women with PVD display shorter LPL sand smaller LPAs than controls but their behavior does not differ when MVC and MVMs are performed. Our results do not support the hypothesis that women with PVD demonstrate abnormalities in PFM contractility on MVC or compliance on MVM.
Studying the snow leopard: reconceptualizing conservation across the China–India border
Authors: LEWIS MICHAEL , SONGSTER E. ELENA 
Published: May 2016

AbstractThe snow leopard is a highly charismatic megafauna that elicits admiration, concern and donations from individuals and NGOs in the West. In its home territories, however, it is a threat to local communities' livestock and a potential source of income for its pelt and parts. Conservation and study are further challenged by its range; snow leopards traverse the borders separating China, India and ten other countries with long histories of tension with each other as well as internal political and economic struggles. This transnational animal provides an ideal case study for the consideration of transnational conservation science in the recent past.
The Proposed European Public Prosecutor’s Office – from a Trojan Horse to a White Elephant?
Authors: CSÚRI András 
Published: May 2016

AbstractThe concept of a European prosecution service operating within a single legal area as proposed by the 1997 Corpus Juris study aimed to tackle impediments to the prosecution of budgetary fraud cases in the transnational context. Subsequent compromises shifted the focus of negotiations from creating a European prosecution service with uniform powers to the integration thereof into the divergent national legal systems. This paper analyses relevant documents up to the draft endorsed by the 2015 Luxembourg Presidency and concludes that the scene is set for autonomous and binding Union decisions to prosecute budgetary fraud at national level. Nonetheless, the low-level of Europeanisation coupled with an increasingly complex model and no real scheme to tackle the fragmentation of national criminal laws fail to enable effective and consistent prosecutions of EU budgetary fraud.
The pathogenesis of bornaviral diseases in mammals
Authors: Tizard Ian , Ball Judith , Stoica George , Payne Susan 
Published: May 2016

AbstractNatural bornavirus infections and their resulting diseases are largely restricted to horses and sheep in Central Europe. The disease also occurs naturally in cats, and can be induced experimentally in laboratory rodents and numerous other mammals. Borna disease virus-1 (BoDV-1), the cause of most cases of mammalian Borna disease, is a negative-stranded RNA virus that replicates within the nucleus of target cells. It causes severe, often lethal, encephalitis in susceptible species. Recent events, especially the discovery of numerous new species of bornaviruses in birds and a report of an acute, lethal bornaviral encephalitis in humans, apparently acquired from squirrels, have revived interest in this remarkable family of viruses. The clinical manifestations of the bornaviral diseases are highly variable. Thus, in addition to acute lethal encephalitis, they can cause persistent neurologic disease associated with diverse behavioral changes. They also cause a severe retinitis resulting in blindness. In this review, we discuss both the pathological lesions observed in mammalian bornaviral disease and the complex pathogenesis of the neurologic disease. Thus infected neurons may be destroyed by T-cell-mediated cytotoxicity. They may die as a result of excessive inflammatory cytokine release from microglia. They may also die as a result of a ‘glutaminergic storm’ due to a failure of infected astrocytes to regulate brain glutamate levels.
Diabetic dyslipidaemia
Authors: Soran Handrean , Schofield Jonathan D. , Adam Safwaan , Durrington Paul N. 
Published: May 2016

Purpose of review
The purpose is to discuss recent developments in the understanding of lipoprotein metabolism in diabetes, the cardiovascular risk associated with both type 1 and type 2 diabetes, recently published guidelines on the management of this risk, concerns over the use of statin treatment in diabetes, and other therapeutic options.

Recent findings
Diabetic dyslipidaemia can be gross with massive hypertriglyceridemia, or subtle with a lipid profile which would be regarded as normal in a nondiabetic patient, but which hides underlying increases in atherogenic subfractions of LDL (e.g., small dense LDL, glycated LDL) and remnant lipoproteins. Statins can decrease these without the clinician being aware from routine biochemistry. In type 2 diabetes, HDL cholesterol levels are often reduced, whereas in type 1, insulin can raise HDL, but its antiatherogenic properties are compromised. Dyslipidaemia and hypertension predate the onset of glycaemia of diabetic proportions (metabolic syndrome). Obese people can thus die of diabetes before they develop it. Obesity should be prevented and treated. Statins decrease the risk of cardiovascular disease in diabetes or metabolic syndrome regardless of whether glycaemia worsens.

Summary
One unassailable truth is that statin therapy is beneficial and should rarely, if ever, be withheld.
Diagnosis and management of hair loss in children
Authors: Castelo-Soccio Leslie 
Published: May 2016

Purpose of review
Hair loss is common in infants and children and the ability to distinguish why a child is losing hair enables providers to distinguish hair loss that is related to infection, autoimmune conditions, nutrition, medications, trauma/traction, or underlying genetic disorders such as ectodermal dysplasias. Making these distinctions leads to best management and guidance for patients and their families.

Recent findings
Careful physical examination of the hair, scalp, skin, and nails coupled with dermoscopy or trichoscopy, or both, can yield more accurate and faster diagnosis. Biopsy is rarely needed in children for hair loss conditions.

Summary
Hair loss, particularly on the scalp, can affect all ages and can impact patients socially and emotionally. The majority of hair loss in children is nonscarring. Diagnosis begins with a good history, including personal and family history, medication use, a thorough physical examination, and use of dermoscopy or trichoscopy, or both. With these, providers can begin to divide hair loss into congenital vs. acquired, and then further subdivide into focal vs. diffuse and scarring vs. nonscarring. Secondary change, including scale and erythema, can further help with diagnosis.
Laparoscopic Adjustable Gastric Banding (LAGB) Plus Anterior Fundoplication Versus LAGB Alone: A Prospective Comparative Study
Authors: Pilone Vincenzo , Vitiello Antonio , Monda Angela , Giglio Francesco , Forestieri Pietro 
Published: May 2016

Background:
Laparoscopic adjustable gastric banding (LAGB) is a well-established and effective bariatric procedure, whose outcomes can be compromised by the slippage and the following removal of the band; the association between LAGB and gastric plication has recently been proved as a successful treatment for morbid obesity. The aim of this prospective randomized study was to compare weight loss and slippage rate between LAGB and LAGB plus anterior fundoplication.

Methods:
From January 2012 to May 2012, a total of 40 patients were allocated to undergo either LAGB (group A, n=20) or LAGB plus anterior fundoplication (group B, n=20). Data on the operative time, complications, hospital stay, total weight loss percentage (%TWL), percentage of excess weight loss (%EWL), and improvement of comorbidities were collected at 6, 12, and 36 months of follow-up.

Results:
All procedures were completed laparoscopically, and no significant difference of mean operative time was found between the 2 groups. The mean hospital stay was longer in group B than in group A (2.3±0.8 vs. 1.4±0.7 d, P<0.005). Greater weight loss was found in group B rather than in group A at 6, 12, and 36 months. Obesity related comorbidities improved in both groups. Number of band regulations and slippage rate were lower in group B.

Conclusions:
Our experience shows that 36 months after surgery LAGB plus anterior fundoplication increases weight loss and reduces the slippage rate.
Cognitive interventions in Alzheimer's and Parkinson's diseases: emerging mechanisms and role of imaging
Authors: Vemuri Prashanthi , Fields Julie , Peter Jessica , Klöppel Stefan 
Published: May 2016

Purpose of reviewThere has been recent debate about the lack of compelling scientific evidence on the efficacy of cognitive interventions. The goal of this study is to review the current state of cognitive interventions in Alzheimer's disease and Parkinson's disease, present emerging mechanisms, and discuss the role of imaging in designing effective intervention strategies.Recent findingsCognitive interventions appear to be promising in Alzheimer's disease and Parkinson's disease. Although feasibility has been shown in mild cognitive impairment, early Alzheimer's disease, and mild to moderate Parkinson's disease, studies to investigate long-term efficacy and mechanisms underlying these interventions are still needed.SummaryThere is a need to conduct scientifically rigorous studies to validate the efficacy of cognitive intervention trials. Future studies will greatly benefit from including longitudinal imaging in their study design. Imaging can be used to demonstrate the efficacy and mechanisms by measuring brain changes over the intervention period. Imaging can also be used to determine biological and disease-related factors that may influence the treatment response, that is, the effect modifiers. Consideration of effect modifiers will allow us to measure the treatment response in biomarkers and cognition with greater sensitivity and also aid in designing trials that will lead to better patient outcomes.
Identifying and managing risks involved in the transition to the EU nZEB decree
Authors: Kantola Mikko , Saari Arto 
Published: May 2016

Purpose
The purpose of this paper is to identify the risks and challenges related to the change in building construction projects to the European Union (EU) zero-energy building (nZEB) decree in the year 2020. Another goal was to create solutions to those risks and challenges.

Design/methodology/approach
A workshop method was chosen to gather up-to-date information from the construction cluster in Finland.

Findings
In the workshop, the main concern was the level of knowledge and know-how with all the parties working with construction projects. As an answer to this challenge, serious and substantial education in the organisations and competence requirements for designers and piloting as much as possible in the next few years was offered. Commissioning consultant was also seen as vital for nZEB project. Tight schedules and unfit project delivery systems were also seen as a risk for nZEB projects. However, modern project delivery systems were seen to be problematic in practice even if they were functional in theory.

Originality/value
The results of the workshop are valuable for all parties working with building construction projects in Finland and the whole EU area.
User engagement in social media – an explorative study of Swedish fashion brands
Authors: Geissinger Andrea , Laurell Christofer 
Published: May 2016

Purpose– The purpose of this paper is to add to the literature by exploring how curvilinear manifestations of user engagement can be explained in the setting of fashion-oriented social media.Design/methodology/approach– This study analyses how ten Swedish fashion brands have been integrated in expressions of user engagement in social media. In total, a material of 11,173 user-generated contents from different types of social media applications over a period of 12 weeks was collected and analysed.Findings– The results of this paper show that user engagement fluctuates considerably over time in social media. It also shows that the degree of engagement varies between different forms of social media applications.Originality/value– This study contributes to the literature on fashion marketing and user engagement by adding empirical support for the suggestion that expressions of engagement found in social media are curvilinear in their nature. It also concludes that highly involved and engaged users, instead of being brand activists, tend to be variety seekers in the studied setting that when taken together represents an emerging managerial challenge for the fashion industry and particularly fashion firms.
Inspiration sources for Australian fast fashion design: tapping into consumer desire
Authors: Payne Alice 
Published: May 2016

Purpose
– The purpose of this paper is to identify both the inspiration sources used by fast fashion designers and ways the designers sort information from the sources during the product development process.

Design/methodology/approach
– This is a qualitative study, drawing on semi-structured interviews conducted with the members of the in-house design teams of three Australian fast fashion companies.

Findings
– Australian fast fashion designers rely on a combination of trend data, sales data, product analysis, and travel for design development ideas. The designers then use the consensus and embodiment methods to interpret and synthesise information from those inspiration sources.

Research limitations/implications
– The empirical data used in the analysis were limited by interviewing fashion designers within only three Australian companies.

Originality/value
– This research augments knowledge of fast fashion product development, in particular designers’ methods and approaches to product design within a volatile and competitive market.
Credit risk signals in CDS market vs agency ratings
Authors: Jacobs Jr Michael , Karagozoglu Ahmet K. , Layish Dina Naples 
Published: May 2016

Purpose
This research aims to model the relationship between the credit risk signals in the credit default swap (CDS) market and agency credit ratings, and determines the factors that help explain the variation in such signals.

Design/methodology/approach
A comprehensive analysis of the differences in the relative credit risk assessments of CDS-based risk signals and agency ratings is provided. It is shown that the divergence between credit risk signals in the CDS market and agency ratings is explained by factors which the rating agencies may consider differently than credit market participants.

Findings
The results suggest that agency credit ratings of relative riskiness of a reference entity do not always correspond with assessments by CDS spreads, as the price of risk is a function of additional macro and micro factors that can be explained using statistical analysis.

Originality/value
This research is unique in modeling the relationship between the credit risk assessments of the CDS market and the agency ratings, which to the best of the authors' knowledge has not been analyzed before in terms of their agreement and the level of discrepancy between them. This model can be used by investors in debt instruments that are not explicitly CDSs or which have illiquid CDS contracts, to replicate market-based, point-in-time credit risk signals. Based on both market-based and firm-specific factors in this model, the results can be used to augment through-the-cycle credit risk assessments, analyze issues surrounding the pricing of CDSs and examine the policies of credit rating agencies.
Two distinct Ras genes from Puccinia striiformis exhibit differential roles in rust pathogenicity and cell death
Authors: Cheng Yulin , Wang Wumei , Yao Juanni , Huang Lili , Voegele Ralf T. , Wang Xiaojie , Kang Zhensheng 
Published: May 2016

SummaryRas genes have been shown to regulate a variety of cellular processes in higher eukaryotes. However, much less is known about their function(s) in fungi, especially plant pathogenic fungi. Here, we report the identification and functional analysis of Ras genes from Puccinia striiformis f. sp. tritici (Pst), an important fungal pathogen in wheat production worldwide. Pst contains two Ras genes, PsRas1 and PsRas2, which share 48.6% similarity at the protein level and fall into two different phylogenetic clades. Both PsRas1 and PsRas2 have conserved protein sequences among different Pst isolates, but exhibit different transcript profiles during Pst infection. Silencing of PsRas1 or PsRas2 indicates that PsRas2 but not PsRas1 contributes significantly to rust pathogenicity. However, overexpression of PsRas1, but not PsRas2, promotes cell death in yeast and plants. Further studies show that all conserved domains of Ras GTPases in PsRas1 are needed to induce this cell death. In plants, PsRas1‐triggered cell death shows similar characteristics as plant hypersensitive response. Our findings suggest that PsRas1 and PsRas2 take over different functions in rust pathogenicity and cell death, thus facilitating the understanding of cell death, pathogenic mechanisms of plant pathogenic fungi and the search for novel pathogen control strategies.
Parent–child interaction: Does parental language matter?
Authors: Menashe Atara , Atzaba‐Poria Naama 
Published: May 2016

Although parental language and behaviour have been widely investigated, few studies have examined their unique and interactive contribution to the parent–child relationship. The current study explores how parental behaviour (sensitivity and non‐intrusiveness) and the use of parental language (exploring and control languages) correlate with parent–child dyadic mutuality. Specifically, we investigated the following questions: (1) ‘Is parental language associated with parent–child dyadic mutuality above and beyond parental behaviour?’ (2) ‘Does parental language moderate the links between parental behaviour and the parent–child dyadic mutuality?’ (3) ‘Do these differences vary between mothers and fathers?’ The sample included 65 children (Mage = 1.97 years, SD = 0.86) and their parents. We observed parental behaviour, parent–child dyadic mutuality, and the type of parental language used during videotaped in‐home observations. The results indicated that parental language and behaviours are distinct components of the parent–child interaction. Parents who used higher levels of exploring language showed higher levels of parent–child dyadic mutuality, even when accounting for parental behaviour. Use of controlling language, however, was not found to be related to the parent–child dyadic mutuality. Different moderation models were found for mothers and fathers. These results highlight the need to distinguish parental language and behaviour when assessing their contribution to the parent–child relationship.
Antidepressant‐like Effects of ZBH2012001, a Novel Potent Serotonin and Norepinephrine Reuptake Inhibitor
Authors: Fan Qiong‐Yin , Xue Rui , Li Ying , Zhang Ting‐Ting , He Xin‐Hua , Fan Shi‐Yong , Li Yun‐Feng , Zhong Bo‐Hua , Zhang You‐Zhi , Li Jin 
Published: May 2016

SummaryAimsThe present study was conducted to evaluate the antidepressant‐like effects of ZBH2012001, a novel potential serotonin and norepinephrine reuptake inhibitor (SNRI).MethodsCompetitive binding assays, calcium flow, and cAMP detection methods were used to determine the affinity of ZBH2012001 for serotonin transporters (SERTs) and norepinephrine transporters (NETs), as well as its selectivity over dopamine transporters (DATs) and 16 other G‐protein‐coupled receptors (GPCRs) or iron channels. The antidepressant‐like effects of ZBH2012001 were determined using the tail suspension test, forced swim test, and learned helplessness paradigm. The pharmacokinetics and acute toxicity of ZBH2012001 were also assessed.ResultsZBH2012001 exhibited a moderate affinity to SERTs and NETs (Ki values were 35.3 ± 2.86 and 225 ± 26.0 nM, respectively); it had no effects on the DATs or the 16 other GPCRs or iron channels. Data from behavioral tests indicated that ZBH2012001 exhibited superior antidepressant‐like effects compared with duloxetine (one of the most used SNRIs) in the three depression models. The pharmacokinetic evaluation of ZBH2012001 indicated that the absolute bioavailability value was 60.5%, and the acute toxicity test indicated that LD50 of ZBH2012001 was 346 mg/kg.ConclusionThese findings suggest that ZBH2012001 is a novel SNRI with superior antidepressant‐like effects, lower acute toxicity and a better pharmacokinetic profile compared with duloxetine. Thus, ZBH2012001 may have potential therapeutic effects in depression disorders.
Development of synaptic networks in the mouse vagal pathway revealed by optical mapping with a voltage‐sensitive dye
Authors: Momose‐Sato Yoko , Sato Katsushige 
Published: May 2016

AbstractThe central issue in developmental neuroscience is when and how neural synaptic networks are established and become functional within the central nervous system (CNS). Investigations of the neural network organization have been hampered because conventional electrophysiological means have some technical limitations. In this study, the multiple‐site optical recording technique with a voltage‐sensitive dye was employed to survey the developmental organization of the vagal system in the mouse embryo. Stimulation of the vagus nerve in E11–E14 mouse embryos elicited optical responses in areas corresponding to the vagal sensory and motor nuclei. Postsynaptic responses in the first‐order sensory nucleus, the nucleus of the tractus solitarius (NTS), were identified from E11, suggesting that sensory information becomes transferred to the brain at this stage. In addition to the NTS, optical responses were identified in the rostral and contralateral brainstem regions, which corresponded to second/higher order nuclei of the vagus nerve including the parabrachial nucleus (PBN). Postsynaptic responses in the second/higher‐order nuclei were detected from E12, suggesting that polysynaptic networks were functional at this stage. We discuss the results of our optical mapping, comparing them with previous findings obtained in the chick and rat embryos, and suggest some fundamental principles in the functional organization of synaptic networks in the embryonic brain.