bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Coagulation-Related Indicators with Postoperative Venous Thromboembolism Occurrence in Patients with Pituitary Tumors
Authors: Xiang Yi , Wu Ya , Liu Huan , Chen Zheng , Pan JinYu 
Published: October 2024

Abstract

Background: The aim of this study was to evaluate the impact of coagulation-related indicators on the incidence of VTE in patients undergoing pituitary tumor resection.
Methods: This study collected clinical data from 300 patients who underwent pituitary adenoma resection from January 2021 to August 2023 in the Department of Neurosurgery, the Second Clinical College of the Army Medical University, China. Logistic regression modeling was used to identify risk factors for VTE. Restricted cubic spline curves were used to characterize the dose-response relationship between coagulation-related indicators and the risk of venous thromboembolism. The area under the curve (AUC) was calculated using the receiver operating characteristic (ROC) curve to evaluate the predictive power of coagulation-related indicators.
Results: Multivariate analysis showed that D-dimer, platelet count and hemoglobin (Hb) were significant predictors of VTE with OR (95%CI) of 1.967 (1.441-2.808), 1.020 (1.013-1.029), and 0.952 (0.914-0.994), respectively. The AUCs for D-dimer, Platelet Count, and Hb were 0.708, 0.731, and 0.712, respectively. The AUC for combining the three coagulation indices was the largest, 0.838.
Conclusions: The combined use of D-dimer, Hb, and platelet count can identify high-risk patients early, enabling timely implementation of antithrombotic strategies.
BRAF V600E Gene Testing Combined with Serum TSH, TGAb, and TPOAb Testing for the Diagnosis of Malignancy in TI-RADS 4 Nodules
Authors: Ying Yajun , zheng lin , Lin Yan 
Published: October 2024

Abstract

Background
To evaluate the diagnostic value of BRAF V600E gene testing combined with serum thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) testing for malignancy in Thyroid Imaging Reporting and Data System (TI-RADS) 4 nodules.
Methods
This was a retrospective study of patients who were diagnosed with TI-RADS 4 nodules via ultrasound examination during an outpatient or inpatient visit, who underwent BRAF V600E gene testing, and who had histopathological results from June 2020 to June 2022 at Taizhou Cancer Hospital. We compared the baseline characteristics, namely, age, sex, presence of lymph node metastasis, tumour size, cytological results, and BRAF V600E gene testing results, of the two patient groups according to their postoperative pathological results. Using postoperative pathology as the gold standard, the sensitivity and specificity of serum TSH, TGAb, and TPOAb and BRAF V600E gene testing alone for diagnosing malignant TI-RADS 4 nodules and the area under the curve (AUC) were calculated. The four indicators were then combined to diagnose TI-RADS 4 nodule malignancy, and the sensitivity, specificity, and AUC were calculated.
Results
Among 112 patients with TI-RADS 4 nodules, 89 had malignant nodules, and 23 had benign nodules. The proportions of patients with TI-RADS 4 nodules aged ≥ 50 years and aged < 50 years were 89.9% (71/79) and 54.5% (18/33), respectively (P = 0.000). The proportion of malignant TI-RADS 4 nodules > 1 cm was significantly greater (86.8% [33/38]) than that of nodules ≤ 1 cm (75.7% [56/74], P = 0.003). None of the benign modules were positive for the BRAF V600E gene mutation, but 73.0% of malignant nodules had this mutation (P = 0.000). Among patients with and without the BRAF V600E gene mutation, 30.8% and 12.8%, respectively, had cervical lymph node metastasis (P = 0.026). The sensitivity and specificity of BRAF V600E gene testing for diagnosing malignancy in TI-RADS 4 nodules were 100% and 48.94%, respectively. However, when the BRAF V600E gene was combined with the serum TSH, TGAb, and TPOAb levels, the specificity and AUC of the combined indicators were 100% and 0.891, respectively.
Conclusion
The combination of BRAF V600E gene testing and serum TSH, TPOAb, and TGAb testing has good clinical value for diagnosing malignancy in TI-RADS 4 nodules.
Exploring BIRC Family Genes as Prognostic Biomarkers and Therapeutic Targets in Prostate Cancer
Authors: Yu Xiao-xiang , Liu Yi , Mo Zeng-mi , Luo Rong-jiang , Chen Wen-kai 
Published: October 2024

Abstract

The potential oncogenic role of Baculoviral inhibitor of apoptosis (IAP) Repeat-Containing (BIRC) genes in prostate cancer (PCa) has yet to be fully investigated. Two genes associated with disease recurrence, BIRC5 and BIRC7, were identified through survival analysis, and prostate cancer patients were categorized into two subtypes, C1 and C2, based on these genes. We performed survival analyses to assess the relationship between subtypes and the prognosis of PCa. Single-cell dataset analysis was used to identify specific cell types with enriched expression of BIRC family genes. Our findings demonstrate that BIRC5 and BIRC7 exhibit higher expression in PCa tissues compared to non-cancerous tissues. High expression of BIRC5 and BIRC7 independently correlates with an adverse prognosis in PCa. The analysis of mechanisms reveals that the differentially expressed genes impact signaling pathways associated with cancer and immunity. BIRC5/BIRC7 correlate with several immune cells infiltrating levels including T cells and macrophages. Furthermore, our research indicates that elevated expression of BIRC5 diminishes the efficacy of immunotherapy in PCa. These findings highlight the potential of BIRC5/BIRC7 or C1 subtype as prognostic biomarkers, offering new insights into viable targets for the development of therapeutic biomarkers and immunotherapeutic drugs for PCa.
Esophageal cancer due to dietary risk factors Deaths Trends Globally, Regionally, and Nationally, 1990-2021: An Age-Period-Cohort Analysis
Authors: Zhuang Yunying , Jiang Yang , Xu Baozhu , Chen Haiying , Huang Yongde , Sun Ruirui , Li Wenhui 
Published: October 2024

Abstract

Background
Esophageal cancer due to dietary risks (ECD) remains a global health challenge, with burden varying by dietary habits, tobacco and alcohol use. This study examines global, regional, and national ECD death trends from 1990 to 2021 using an age-period-cohort (APC) model to explore influences of aging, temporal changes, and generational shifts.
Methods
Data from the Global Burden of Disease Study 2021, encompassing 204 countries and territories, were analyzed. APC modeling was applied to assess crude and age-standardized death rates, alongside percentage changes from 1990 to 2021. Key metrics included net drift coefficients and relative death risks across age groups, periods, and cohorts.
Results
Global ECD cases decreased from 74,453.71 in 1990 to 56,939.09 in 2021, with an age-standardized death rate of 0.66 (95% CI: -0.14, 1.38) per 100,000 population. High SDI regions showed the highest overall ECD death rate (1.25, 95% CI: -0.27, 2.54 per 100,000), while low SDI regions exhibited the highest age-standardized death rate (1.48, 95% CI: -0.3, 2.88 per 100,000). India, China, USA, and Brazil reported the highest national ECD cases, with significant variations across age groups and regions.
Conclusion
A global decline in age-standardized ECD death rates is observed, especially in high-middle and middle SDI regions. Nonetheless, low SDI regions continue to experience higher rates, underscoring the need for enhanced public health interventions, including better healthcare access, early detection, and dietary modifications to reduce ECD deaths and address socioeconomic disparities.
An investigation of English academic writing strategies employed by Indonesian graduate students in a non-native English speaking environment
Authors: Subandowo Dedy , Sárdi Csilla , Thresia Fenny 
Published: October 2024

Abstract

This study investigates Indonesian graduate students' writing strategies for academic essay assignments at Hungarian universities. The aim is to understand the specific phases and strategies used during the writing process: pre-writing, writing, and post-writing. Employing a qualitative approach, data were collected mainly through semi-structured interviews. Eleven Indonesian students from six universities in the Faculty of Social Sciences and Economics were involved in the study. The interviews were transcribed using the Web Speech API. Coding and theme classification were performed using ATLAS ti. The results indicate that the students utilize a total of sixteen stages and employ 89 strategies when completing their academic essays. During the pre-writing stage, the participants engage with five specific themes: planning, assigned essay topics, the provision of data sources, literature studies, and content structuring. During the writing stage, a total of eight phases were utilized. These included preparatory stages, research and information management, fulfilling the required length of the text, enhancing language to avoid repetition, improving content and language, revising content and language, ensuring academic integrity, and maintaining motivation throughout the writing process. In the post-writing stage, three phases were implemented, which involved receiving feedback and making revisions, conducting a final review, and completing post-submission tasks.
Enhancing Anesthesia Training: Integrating Visual Ultrasound and Case-Based Learning
Authors: Du Yan , Cen Jiangshan , Zheng Chenpeng , Hu Xiaoling 
Published: October 2024

Abstract

Background: Ultrasound-guided nerve blocks, which provide precise diagnosis and treatment, are critical for anesthesiologists to master. In particular, for beginners under anesthesia, proficiency in ultrasound is challenging.
Objective: This study aimed to compare the teaching effects of visual ultrasound combined with case-based learning and the traditional lecture method in anesthesia training for undergraduate interns.
Methods: Thirty anesthesia undergraduate interns from the Ultrasound Department at Chongqing Emergency Medical Center, trained from January 2022 to March 2024, were selected as participants. They were randomly divided into two groups: the experimental group (n=15), which received visual ultrasound instruction combined with case-based learning, and the control group (n=15), which received traditional teaching methods. The effects of the teaching methods were evaluated through a combination of theoretical exams, ultrasonic map recognition, and a multidimensional questionnaire. An independent sample t test was used for statistical analysis in this study.
Results: The experimental group demonstrated superior performance in theory assessment and ultrasonic map recognition results after training [(75.77±4.51) vs. (89.23±3.76) and (74.70±2.71) vs. (90.33±1.95)], indicating particular strengths (P<0.05). Additionally, course evaluation surveys indicated that teaching satisfaction was markedly higher in the experimental group than in the control group (P<0.05).
Conclusion: Integrating visual ultrasound with case-based learning significantly enhances both the teaching efficiency and practical clinical skills of students in anesthesia training.
Asthma is risk factor for complication after lung resection in older patients with non-small cell lung cancer associated with chronic obstructive pulmonary disease: a retrospective study
Authors: Iijima Yoshihito , Mizoguchi Takaki , Ishikawa Masahito , Iwai Shun , Motono Nozomu , Uramoto Hidetaka 
Published: October 2024

Abstract

Background
The risk factors for postoperative complications in patients with chronic obstructive pulmonary disease (COPD) remain unclear. In this study, we aimed to identify the risk factors for postoperative pulmonary complications in older patients with lung cancer associated with COPD.
Methods
We retrospectively analyzed the data from 153 older patients who underwent pulmonary surgery for non-small-cell lung cancer associated with COPD between 2009 and 2018. Patients were categorized into two groups based on the presence or absence of Clavien–Dindo classification grade ≥ 2 pulmonary complications. We examined their clinicopathological characteristics and outcomes. Differences between the groups were assessed using univariate and multivariate analyses to identify risk factors.
Results
Pulmonary complications occurred in 42 (27.5%) patients. The group with postoperative complications had significantly longer durations of chest tube use and hospital stay than the group without complications. No perioperative or hospital deaths occurred within 1 or 3 months. Univariate analysis identified coexisting asthma, anemia (hemoglobin < 12.2 g/dL), thoracotomy approach, prolonged operation time (> 220 min), pathological stage III, and fibrin glue use as risk factors for postoperative pulmonary complications. Multivariate analysis confirmed coexisting asthma and fibrin glue use as significant risk factors.
Conclusions
Asthma is a risk factor for postoperative pulmonary complications, particularly pneumonia, atelectasis, and sputum discharge disorder, and intraoperative fibrin glue use significantly reduced postoperative pulmonary complications, in our patient population. Surgical indications and postoperative care should be carefully considered in patients with asthma.
Transarterial embolization of anterior cranial fossa dural arteriovenous fistulas as a first-line approach: a retrospective single-center study
Authors: Zhang Guanghao , Pang Miao , Duan Guoli , Li Zhe , Chen Rundong , Shang Chenghao , Zhang Yuhang , Huang Qinghai , Xu Yi , Li Qiang , Liu Jianmin 
Published: October 2024

Abstract

Background
Anterior cranial fossa (ACF) dural arteriovenous fistulas (DAVFs) present unique treatment challenges due to their complex angioarchitecture and high risk of hemorrhage. Recent advancements in endovascular techniques have highlighted the potential of transarterial embolization in managing these fistulas.
Objective
The purpose of this study is to evaluate the clinical and angiographic outcomes of transarterial embolization (TAE) as a first-line treatment for ACF DAVFs over a twenty-year period.
Methods
From March 2001 to September 2021, a total of 54 patients harboring ACF DAVFs underwent TAE as a first-line approach at our institution. The clinical presentation, angiographic features, procedure-related complications, clinical outcomes, and angiographic results were analyzed retrospectively.
Results
Among 54 ACF DAVF treated, there were 48 males and 6 females, with a mean age of 52.5 (52.5 ± 13.0) years. Intracranial hemorrhage (51.9%, 28/54) was the most common symptom. A total of 57 embolization attempts were performed. 83.3% achieved complete angiographic occlusion immediately post-TAE. The average hospital stay post-treatment was 10.4 days. Complications occurred in 3.7% of patients. 97.6% (41/42) experienced symptom improvement or stabilization during clinical follow-up. DSA follow-up showed that 85.0% (34/40) maintained complete fistula occlusion. Angiographic recurrence occurred in one (2.9%, 1/34,) patient without any symptoms.
Conclusions
TAE for ACF DAVFs demonstrates a high rate of complete occlusion with an acceptable safety profile. Further comparative studies with other treatment approaches are recommended to validate these findings.
Advancement in scanning magnetic microscopy utilizing high-sensitivity room-temperature TMR sensors for geological applications
Authors: Oda Hirokuni , Kumagai Seiji , Fujiwara Kosuke , Matsuzaki Hitoshi , Wagatsuma Hiroshi , Oogane Mikihiko , Kubota Hitoshi , Fukuyo Naoto , Tanimoto Akihiro 
Published: October 2024

Abstract

Scanning magnetic microscopes enable high-sensitivity mapping of magnetic fields in thin geological sections, facilitating submillimeter-to-submicrometer scale studies of paleomagnetism and rock magnetism. Magnetic fields of geological samples have been mapped using various sensors, including Hall-effect devices, magneto-impedance devices, superconducting quantum interference devices (SQUIDs), quantum diamond devices, and tunnel magnetoresistance (TMR) devices. This study proposes magnetic microscopy using high-sensitivity room-temperature TMR sensors developed for magnetocardiography. The goal was to create high-performance magnetic microscopes that do not require laborious techniques, such as cryogenic technology. An XYZ stage developed for a scanning SQUID microscope (SSM) was used to demonstrate and evaluate magnetic microscopy with TMR sensors. The original TMR sensors developed for biomagnetic sensing composed of serially connected TMR elements with a total length of 3 mm were shortened to 1 mm (Sensor #1) and 0.4 mm length (Sensor #2). Background measurements at 50 Hz show magnetic field sensitivities better than 200 nT/√Hz and 600 nT/√Hz at 1 Hz for Sensor #1 and Sensor #2, respectively. By averaging 10 points of the original 50 Hz sampling, magnetic field sensitivities are better than 30 nT/√Hz and 90 nT/√Hz at 1 Hz for Sensor #1 and Sensor #2, respectively. To demonstrate TMR sensors as magnetic microscopes, a vertically magnetized Hawaii basalt thin section was measured and compared with a SQUID-acquired magnetic field map. Magnetic scanning images obtained with TMR sensors on a 0.1 mm grid were compared with those of scanning SQUID microscope (SSM) after adjusting the lift-off by upward continuation and integrated along the length of the sensors. The results demonstrated that magnetic images for 1 mm-long (0.4 mm-long) sensors aligned along the y-axis and x-axis are consistent with those after upward continuation to 0.3 mm (0.25 mm) and 0.4 mm (0.25 mm) and convolution by 1×10 (1×4) and 10×1 (4×1) matrix, respectively. Overall, the high-sensitivity TMR sensors exhibited promising performance. Further improvements can be made by optimizing the sensors, preamplifiers, and measurement systems for magnetic microscopy to achieve an optimum target resolution.
Whether thoracic surgeon fatigue affects surgical quality?
Authors: Li Jun , Ge Yong , Liu Jingsong , Ma Tianyue , Xie Zexin , Zhou Xiaotong , Zhang Hao 
Published: October 2024

Abstract

Background
This study aimed to investigate the potential association between the one-day cumulative surgical time of the surgeon and postoperative outcomes in patients undergoing thoracoscopic anatomical lung resections.
Methods
We define the daily cumulative surgical time for the first surgery on that day is zero, the daily cumulative surgical time for the second surgery is the single operation duration for the first surgery, the daily cumulative surgical time for the third surgery is the single operation duration for the first surgery plus the single operation duration for the second surgery, and so on. And if a certain value is less than the median of cumulative surgical time, the surgery is included in the 'shorter-duration surgery group'. Conversely, the surgery is included in the 'longer-duration surgery group'. In addition, we compared baseline data and used multifactorial logistic regression analysis to determine whether cumulative surgical time was a risk factor for single operation duration and complication rates.
Results
The multivariate logistic analysis showed that the single operation duration decreased with a decrease in the cumulative surgical time (odds ratio [OR], 0.644; 95% confidence interval [CI], 0.435–0.955; P = 0.029). Moreover, the incidence of complications reduced when the single operation duration was less than 109 min (OR, 0.153; 95% CI, 0.074–0.318; P < 0.001). However, the cumulative surgical time was not associated with an increased incidence of complications (P = 0.069).
Conclusions
This study found that a long one-day cumulative surgical time of the surgeon is associated with prolonged single operation duration, no significant effect was observed on the complications. Furthermore, an increase in the single operation duration can lead to an increase in the incidence of complications.
Stress hyperglycemia is associated with early neurologic deterioration in patients with acute ischemic stroke after intravenous thrombolysis without hemorrhagic transformation Running title: Stress hyperglycemia for END after intravenous thrombolysiss
Authors: Lei Junjie , Peng Yanfang , Li Wenbin , Chen Xiaofeng , Fan Qian , Liu Chenhao , Tang Chaogang , Luo Shijian , Mai Weihua , Zhang Lei 
Published: October 2024

Abstract

Background
This aimed to elucidate the impact of stress hyperglycemia on early neurological deterioration (END) in patients with acute non-cardiogenic cerebral infarction who did not experience hemorrhagic transformation following intravenous thrombolysis to identify risk factors associated with END.
Methods
This retrospective case-control study analyzed data from consecutive patients who received intravenous thrombolysis for acute ischemic stroke (AIS) without hemorrhagic transformation at the Stroke Center of The Fifth Affiliated Hospital of Sun Yat-sen University from January 2018 to February 2023. END was defined as an increase of more than 2 points on the National Institutes of Health Stroke Scale (NIHSS) within 7 days of admission.
Results
A total of 250 patients (56 males, 22.4%) were included, with a mean age of 63.34 ± 12.90 years. Of them, 41 were classified into the END group and 209 into the non-END group. Stress hyperglycemia ratio (SHR) demonstrated a significant correlation with END (r=-0.003, P = 0.003). HbA1c (OR = 0.68, 95% CI: 0.481–0.921) and SHR (OR = 0.00, 95% CI: 0.0-0.051) were independently associated with END. Receiver-operating characteristic (ROC) curve analysis indicated that SHR had a sensitivity of 79.9%, specificity of 88.8%, and an area under the curve (AUC) of 0.857 for predicting END.
Conclusions
SHR was significantly associated with END in patients with acute non-cardioembolic cerebral infarction who did not undergo hemorrhagic transformation after intravenous thrombolysis
Inpatient Opioid Utilization After Robot-assisted versus Laparoscopic Bariatric Surgery
Authors: Fair Lucas , Kruger Jessica , Waddimba Anthony , Baker Bailey , Ogola Gerald , Davis Daniel 
Published: October 2024

Abstract

Introduction: Robotic platforms are increasingly utilized in bariatric surgery to overcome technical limitations of traditional laparoscopy. However, the impact of robotics on postoperative pain control is not fully understood. The present study aimed to compare pain control outcomes following primary bariatric surgery performed via robot-assisted approaches versus conventional laparoscopy.
Methods: This was an IRB-approved retrospective investigation of all adults who underwent primary bariatric surgeries at a single institution from August 2016 to January 2019. Multivariable generalized linear and ordinal logistic regression models were fitted to test predictive associations of the (robotic vs laparoscopic) surgical technique with post-operative, in-hospital opioids consumption and pain intensity ratings, independent of co-varying risk factors.
Results: A total of 340 patients (201 undergoing robotic, 139 laparoscopic procedures) were included in the study. Baseline preoperative characteristics were similar between comparison groups, except mean BMI was significantly higher among robotic surgery recipients (47.7 vs 44.0 kg/m2; p<0.001). Postoperative in-hospital opioid consumption did not significantly differ among recipients of robotic versus laparoscopic bariatric surgery. No difference was detected between comparison cohorts in total inpatient opioid use (p=0.300), opioid use in PACU (p=0.977), nor average opioid use per inpatient day (p=0.178). Similarly, in multivariable ordinal logistic regression models of postoperative day 0 and postoperative day 1 pain ratings, perceived pain intensity was not significantly higher following robotic versus laparoscopic primary bariatric surgeries, after accounting for other risk factors.
Conclusion: Compared to conventional laparoscopy, robotic primary bariatric procedures did not independently increase post-operative, in-hospital opioid utilization nor pain intensity.