bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC)
Authors: Roman Mary J. , Pugh Norma L. , Hendershot Tabitha P. , Devereux Richard B. , Dietz Hal , Holmes Kathryn , Eagle Kim A. , LeMaire Scott A. , Milewicz Dianna M. , Morris Shaine A. , Pyeritz Reed E. , Ravekes William J. , Shohet Ralph V. , Silberbach Michael , Dietz Harry C. , Habashi Jennifer , Prakash Siddharth K. , Maslen Cheryl L. , Song Howard K. , Bavaria Joseph E. , Milewski Karianna , Weinsaft Jonathan W. , McDonnell Nazli , Asch Federico M. , Tolunay H. Eser , Desvigne‐Nickens Patrice , Tseng Hung , Kroner Barbara L. 
Published: August 2016

Background

The risk of aortic complications associated with pregnancy in women with Marfan syndrome (
MFS
) is not fully understood.

Methods and Results

MFS
women participating in the large National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (Gen
TAC
) were evaluated. Among 184 women with
MFS
in whom pregnancy information was available, 94 (51%) had a total of 227 pregnancies. Among the women with pregnancies, 10 (10.6%) experienced a pregnancy‐related aortic complication (4 type A and 3 type B dissections, 1 coronary artery dissection, and 2 with significant [≥3 mm] aortic growth). Five of 7 aortic dissections, including all 3 type B, and the coronary dissection (75% of all dissections) occurred in the postpartum period. Only 5 of 8 women with pregnancy‐associated dissection were aware of their
MFS
diagnosis. The rate of aortic dissection was higher during the pregnancy and postpartum period (5.4 per 100 person‐years vs 0.6 per 100 person‐years of nonpregnancy; rate ratio, 8.4 [95% CI=3.9, 18.4];
P
<0.0001).

Conclusions

Pregnancy in
MFS
is associated with an increased risk of aortic dissection, both types A and B, particularly in the immediate postpartum period. Lack of knowledge of underlying
MFS
diagnosis before aortic dissection is a major contributing factor. These findings underscore the need for early diagnosis, prepregnancy risk counseling, and multidisciplinary peripartum management.
Evaluating Medium-Range Tropical Cyclone Forecasts in Uniform- and Variable-Resolution Global Models
Authors: Davis Christopher A. , Ahijevych David A. , Wang Wei , Skamarock William C. 
Published: August 2016

AbstractAn evaluation of medium-range forecasts of tropical cyclones (TCs) is performed, covering the eastern North Pacific basin during the period 1 August–3 November 2014. Real-time forecasts from the Model for Prediction Across Scales (MPAS) and operational forecasts from the National Centers for Environmental Prediction (NCEP) Global Forecast System (GFS) are evaluated. A new TC-verification method is introduced that treats TC tracks as objects. The method identifies matching pairs of forecast and observed tracks, missed and false alarm tracks, and derives statistics using a multicategory contingency table methodology. The formalism includes track, intensity, and genesis.Two configurations of MPAS, a uniform 15-km mesh and a variable-resolution mesh transitioning from 60 km globally to 15 km over the eastern Pacific, are compared with each other and with the operational GFS. The two configurations of MPAS reveal highly similar forecast skill and biases through at least day 7. This result supports the effectiveness of TC prediction using variable resolution.Both MPAS and the GFS suffer from biases in predictions of genesis at longer time ranges; MPAS produces too many storms whereas the GFS produces too few. MPAS better discriminates hurricanes than does the GFS, but the false alarms in MPAS lower overall forecast skill in the medium range relative to GFS. The biases in MPAS forecasts are traced to errors in the parameterization of shallow convection south of the equator and the resulting erroneous invigoration of the ITCZ over the eastern North Pacific.
Small Change
Authors: Love Heather 
Published: August 2016

Abstract
In recent debates about reading methods, in the field of microsociology, and in the history of the novel, small-scale observations of everyday life tend to be understood as conservative, reinforcing the status quo. Through a reading of Claudia Rankine’s Citizen: An American Lyric (2014) in relation to documentary lyric and the online genre of microaggressions, this essay argues for the political utility of description at the micro scale.
Making the connection – shared molecular machinery and evolutionary links underlie the formation and plasticity of occluding junctions and synapses
Authors: Harden Nicholas , Wang Simon Ji Hau , Krieger Charles 
Published: August 2016

ABSTRACT
The pleated septate junction (pSJ), an ancient structure for cell–cell contact in invertebrate epithelia, has protein components that are found in three more-recent junctional structures, the neuronal synapse, the paranodal region of the myelinated axon and the vertebrate epithelial tight junction. These more-recent structures appear to have evolved through alterations of the ancestral septate junction. During its formation in the developing animal, the pSJ exhibits plasticity, although the final structure is extremely robust. Similar to the immature pSJ, the synapse and tight junctions both exhibit plasticity, and we consider evidence that this plasticity comes at least in part from the interaction of members of the immunoglobulin cell adhesion molecule superfamily with highly regulated membrane-associated guanylate kinases. This plasticity regulation probably arose in order to modulate the ancestral pSJ and is maintained in the derived structures; we suggest that it would be beneficial when studying plasticity of one of these structures to consider the literature on the others. Finally, looking beyond the junctions, we highlight parallels between epithelial and synaptic membranes, which both show a polarized distribution of many of the same proteins – evidence that determinants of apicobasal polarity in epithelia also participate in patterning of the synapse.
Transcriptional regulation of mammalian autophagy at a glance
Authors: Füllgrabe Jens , Ghislat Ghita , Cho Dong-Hyung , Rubinsztein David C. 
Published: August 2016

ABSTRACT
Macroautophagy, hereafter referred to as autophagy, is a catabolic process that results in the lysosomal degradation of cytoplasmic contents ranging from abnormal proteins to damaged cell organelles. It is activated under diverse conditions, including nutrient deprivation and hypoxia. During autophagy, members of the core autophagy-related (ATG) family of proteins mediate membrane rearrangements, which lead to the engulfment and degradation of cytoplasmic cargo. Recently, the nuclear regulation of autophagy, especially by transcription factors and histone modifiers, has gained increased attention. These factors are not only involved in rapid responses to autophagic stimuli, but also regulate the long-term outcome of autophagy. Now there are more than 20 transcription factors that have been shown to be linked to the autophagic process. However, their interplay and timing appear enigmatic as several have been individually shown to act as major regulators of autophagy. This Cell Science at a Glance article and the accompanying poster highlights the main cellular regulators of transcription involved in mammalian autophagy and their target genes.
DPPH Radical-Scavenging Activity and Kinetics of Antioxidant Agent Hesperidin in Pure Aqueous Micellar Solutions
Authors: Jabbari Morteza , Jabbari Azam 
Published: August 2016

Abstract
The antioxidant ability of bioactive agent hesperidin was assessed in terms of radical-scavenging activity (RSA) against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical in aqueous colloidal media containing micelle using UV–vis spectrophotometry. The DPPH assay was carried out at 25.0 ± 0.1 °C and cationic surfactant CTAB and anionic surfactant SDS at various concentrations above the critical micelle concentration (CMC). The rates of the antioxidant reaction (Rs) of hesperidin were also measured in the micelle systems. The activity and rate of the DPPH radical scavenging by hesperidin were found to depend on concentration and nature of the surfactants used, so that both RSA and Rs values increase with increasing concentration of micelles CTAB and SDS. Finally, the micelle effects on the antioxidant efficiency were explained based on possible interaction modes between hesperidin and the micellar surfaces.
Aplikasi Panduan Ibadah Haji Berbasis Android
Authors: Syahril Deddy Sucipta , Isnanto R. Rizal , Kridalukmana Rinta 
Published: August 2016

This is an application for hajj guidance based on Android.The application is made using software Eclipse IDE and Android SDK with Java as a programming language. Stage of development software used is SDLC (Software Development Life Cycle) by using the method waterfall, as modeling software used is UML (Unified Modelling Language). Steps in this research are software requirement analysis, design, coding, and system testing. Functional testing using a method of black box.The result of this research is an application of hajj guidance based on Android can be use to guide in hajj. The application can run well on a device with a minimum of Android operating system version 4.2 (Jelly Bean) with the storage space available at least 25 MB. Function menus and buttons is operated appropriately according to their functions. This application for hajj guidance can be used as a medium to help moslems in hajj.
Management of infections in the immunocompromised child: General principles
Authors: Allen Upton D. 
Published: August 2016

Infections represent an ongoing challenge for immunocompromised patients. Children are particularly vulnerable because of several age-related issues that relate in part to immune prematurity. This review addresses the challenges in managing infections among immunocompromised children and highlights several general principles that guide management. Statement of novelty: This work provides important guidance to clinicians who are involved in the management of pediatric patients with an ever-expanding spectrum of immunocompromising disorders.
Effect of Adding Crushed Glass to Asphalt Mix
Authors: Issa Y. 
Published: August 2016

Abstract The need to modify conventional pavement rises due to high maintenance cost of the highway systems. With the continuously increased consumption, a large amount of waste glass materials is generated annually in the world. This paper aims to study the performance of pavement asphalt in which a fractional aggregate is replaced with crushed glass. In this paper, some important properties of asphalt mix, including stability, flow, specific gravity and air voids are investigated. The original sample is prepared without adding glass for different percentages of bitumen. Other samples are prepared by adding crushed glass to the mix with 5%, 10%, and 15% by aggregate weight. The results show that the properties of glass-asphalt mixture are improved in comparison with normal asphalt pavement. It is concluded that the use of waste glass in asphalt pavement is desirable.
The Assessment of the Slip Influence on the Deflection of the Steel Plate-Concrete Composite Beams
Authors: Kisała D. , Furtak K. 
Published: August 2016

Abstract
The aim of this paper is to present an assessment of the slip influence on the deflection of the steel plate-concrete composite beams, which are a new type of a design concept. The proposed method is based on the procedure included in the PN-EN 1992-1-1, which has been modified with taking into consideration interface slip. The theoretical analysis was verified by experimental studies.
Influence of Compliance Criteria on the Value of Reliability Index
Authors: Skrzypczak I. , Buda-Ożóg L. 
Published: August 2016

Abstract Statistical conformity criteria for the compressive strength of concrete are a matter of debate. The criteria can have prejudicial effects on construction quality and reliability. Hence, the usefulness of statistical criteria for the small sample size n=3 is questioned. These defects can cause a reduction in the quality of produced concrete and, consequently, too much risk for the recipient (investor). For this reason, the influence of conformity control on the value of the reliability index of concrete and reinforced concrete has been determined. The authors limited their consideration to the recommended standards PN-EN 206-1, PN-EN 1992 and ISO 2394 method of reliability index, which belongs to the analytical methods FORM (First Order Reliability Method). It assumes that the random variables are defined by two parameters of the normal distribution or an equivalent normal: the mean and the standard deviation. The impact of conformity control for n=3 for concrete structures, designed according to the Eurocode 1992, for which the compressive strength of concrete is the capacity dominant parameter (sensitivity factor of dominating resistance parameter according to the FORM is 0.8), has been determined by evaluation of the reliability index.
Evaluation of Data Obtained from Expert Opinions in Multi-Criteria Analyses of Construction Investment Variants
Authors: Szafranko E. 
Published: August 2016

Abstract Planning a construction project, the investor frequently faces the choice of the option of the planned investment. Assessment of options is difficult due to the complex nature of construction projects. Various methods of multi-criteria evaluation are successfully applied in the assessment and analysis of options. For those methods to work, a handful of information must be prepared beforehand. Among others, it is necessary to establish the assessment criteria and determine their weight for specific cases. This stage is implemented in cooperation with experts. The results of evaluations, obtained on the basis of the experts’ opinions, must be processed and prepared. The paper will discuss one possible option for assessing the experts’ opinion.
Computation of Thin-Walled Cross-Section Resistance to Local Buckling with the Use of the Critical Plate Method
Authors: Szychowski A. 
Published: August 2016

Abstract Thin-walled bars currently applied in metal construction engineering belong to a group of members, the cross-section res i stance of which is affected by the phenomena of local or distortional stability loss. This results from the fact that the cross-section of such a bar consists of slender-plate elements. The study presents the method of calculating the resistance of the cross-section susceptible to local buckling which is based on the loss of stability of the weakest plate (wall). The “Critical Plate” (CP) was identified by comparing critical stress in cross-section component plates under a given stress condition. Then, the CP showing the lowest critical stress was modelled, depending on boundary conditions, as an internal or cantilever element elastically restrained in the restraining plate (RP). Longitudinal stress distribution was accounted for by means of a constant, linear or non-linear (acc. the second degree parabola) function. For the critical buckling stress, as calculated above, the local critical resistance of the cross-section was determined, which sets a limit on the validity of the Vlasov theory. In order to determine the design ultimate resistance of the cross-section, the effective width theory was applied, while taking into consideration the assumptions specified in the study. The application of the Critical Plate Method (CPM) was presented in the examples. Analytical calculation results were compared with selected experimental findings. It was demonstrated that taking into consideration the CP elastic restraint and longitudinal stress variation results in a more accurate representation of thin-walled element behaviour in the engineering computational model.
The analysis of thermal and flow characteristics of the condensation of refrigerant zeotropic mixtures in minichannels
Authors: Bohdal Tadeusz , Widomska Katarzyna , Sikora Małgorzata 
Published: August 2016

Abstract
The paper presents the results of experimental heat transfer and pressure drop during condensation of the single component refrigerant R134a and zeotropic mixtures R404A, R407C, and R410A in tube minichannels of internal diameter from the range 0.31-3.30 mm. The local values and the average of heat transfer coefficient and pressure drop in the whole range of the change in mass quality were measured. On the basis of the obtained test results there was illustrated the influence of the change of mass vapor quality, the mass flux density, and the inner diameter of channel on the studied parameters. These results were compared with the calculation results based on the relations postulated by other authors. The discrepancy range was ± 50%. On the basis of given test results own correlation was developed to calculate the heat transfer coefficient and pressure drop of tested refrigerants which presents the obtained results in a range of discrepancy of ±25%.
Numerical analysis of the steam flow field in shell and tube heat exchanger
Authors: Bartoszewicz Jarosław , Bogusławski Leon 
Published: August 2016

Abstract
In the paper, the results of numerical simulations of the steam flow in a shell and tube heat exchanger are presented. The efficiency of different models of turbulence was tested. In numerical calculations the following turbulence models were used: k-ε, RNG k-ε, Wilcox k-ω, Chen-Kim k-ε, and Lam-Bremhorst k-ε. Numerical analysis of the steam flow was carried out assuming that the flow at the inlet section of the heat exchanger were divided into three parts. The angle of steam flow at inlet section was determined individually in order to obtain the best configuration of entry vanes and hence improve the heat exchanger construction. Results of numerical studies were verified experimentally for a real heat exchanger. The modification of the inlet flow direction according to theoretical considerations causes the increase of thermal power of a heat exchanger of about 14%.
Mid-regional pro-adrenomedullin (MR-proADM) and mid-regional pro-atrial natriuretic peptide (MR-proANP) in severe aortic valve stenosis: association with outcome after transcatheter aortic valve implantation (TAVI)
Authors: Baldenhofer Gerd , Laule Michael , Mockel Martin , Sanad Wasiem , Knebel Fabian , Dreger Henryk , Leonhardt Franziska , Sander Michael , Grubitzsch Herko , Baumann Gert , Stangl Karl , Stangl Verena 
Published: August 2016

Abstract

Background:
This study aimed to assess the association of mid-regional (MR) pro-adrenomedullin (MR-proADM) and MR-pro-A-type natriuretic peptide (MR-proANP) in comparison to N-terminal pro-natriuretic peptide (NT-proBNP) with outcome in patients with aortic stenosis (AS) treated with transcatheter aortic valve implantation (TAVI).

Methods:
One hundred consecutive TAVI patients were included in this prospective study. Association of preinterventional levels of MR-proADM, MR-proANP, NT-proBNP, C-reactive protein (CrP), and high-sensitive cardiac Troponin T (hsTN) with 30-day and 1-year outcome was analyzed.

Results:
There was no association with 30-day outcome, but all markers were associated with 1-year cardiovascular events and all-cause mortality. The combined biomarker analysis further improved risk prediction.

Conclusions:
In TAVI patients MR-proADM, MR-proANP, and NT-proBNP are promising predictors of adverse events within 1 year. Integration of these biomarkers into decision pathways may help to identify patients at higher risk.
Predictive performance of TPA testing for recurrent disease during follow-up after curative intent surgery for colorectal carcinoma
Authors: van der Sluis Frederik J. , Zhan Zhuozhao , Verberne Charlotte J. , Muller Kobold Anneke C. , Wiggers Theo , de Bock Geertruida H. 
Published: August 2016

Abstract

Background:
The aim of the present study was to investigate the predictive performance of serial tissue polypeptide antigen (TPA) testing after curative intent resection for detection of recurrence of colorectal malignancy.

Methods:
Serum samples were obtained in 572 patients from three different hospitals during follow-up after surgery. Test characteristics of serial TPA testing were assessed using a cut-off value of 75 U/L. The relation with American Joint Committee on Cancer stage and the potential additive value of tissue polypeptide antigen testing upon standard carcinoembryonic antigen (CEA) testing were investigated.

Results:
The area under the receiver operating characteristic curve of TPA for recurrent disease was 0.70, indicating marginal usefulness as a predictive test. Forty percent of cases that were detected by CEA testing would have been missed by TPA testing alone, whilst most cases missed by CEA were also not detected by TPA testing. In the subpopulation of patients with stage III disease predictive performance was good (area under the curve 0.92 within 30 days of diagnosing recurrent disease). In this group of patients, 86% of cases that were detected by CEA were also detected by TPA.

Conclusions:
Overall, TPA is a relatively poor predictor for recurrent disease during follow-up. When looking at the specific subpopulation of patients with stage III disease predictive performance of TPA was good. However, TPA testing was not found to be superior to CEA testing in this specific subpopulation.
Optimization and validation of moving average quality control procedures using bias detection curves and moving average validation charts
Authors: van Rossum Huub H. , Kemperman Hans 
Published: August 2016

Abstract

Background:
To date, no practical tools are available to obtain optimal settings for moving average (MA) as a continuous analytical quality control instrument. Also, there is no knowledge of the true bias detection properties of applied MA. We describe the use of bias detection curves for MA optimization and MA validation charts for validation of MA.

Methods:
MA optimization was performed on a data set of previously obtained consecutive assay results. Bias introduction and MA bias detection were simulated for multiple MA procedures (combination of truncation limits, calculation algorithms and control limits) and performed for various biases. Bias detection curves were generated by plotting the median number of test results needed for bias detection against the simulated introduced bias. In MA validation charts the minimum, median, and maximum numbers of assay results required for MA bias detection are shown for various bias. Their use was demonstrated for sodium, potassium, and albumin.

Results:
Bias detection curves allowed optimization of MA settings by graphical comparison of bias detection properties of multiple MA. The optimal MA was selected based on the bias detection characteristics obtained. MA validation charts were generated for selected optimal MA and provided insight into the range of results required for MA bias detection.

Conclusions:
Bias detection curves and MA validation charts are useful tools for optimization and validation of MA procedures.
Calabi flow on toric varieties with bounded Sobolev constant, I
Authors: Huang Hongnian 
Published: August 2016

Abstract
Let (X, P) be a toric variety. In this note, we show that the C0-norm of the Calabi flow φ(t) on X
is uniformly bounded in [0, T) if the Sobolev constant of φ(t) is uniformly bounded in [0, T). We also show
that if (X, P) is uniform K-stable, then the modified Calabi flow converges exponentially fast to an extremal
Kähler metric if the Ricci curvature and the Sobolev constant are uniformly bounded. At last, we discuss an
extension of our results to a quasi-proper Kähler manifold.