bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological and genetic characterization ofPterygodermatites(Paucipectines)zygodontomis(Nematoda: Rictulariidae) fromNecromys lasiurus(Rodentia: Sigmodontinae) from Uberlândia, Brazil
Authors: Costa N.A. , Simões R.O. , Vilela R.V. , Souza J.G.R. , Cardoso S.T. , Leiner N.O. , Gentile R. , Maldonado A. 
Published: October 2017

AbstractPterygodermatites (Paucipectines) zygodontomis, a nematode parasite of the small intestine of the rodentNecromys lasiurus, from Uberlândia, Minas Gerais state, Brazil, was analysed by light and scanning electron microscopy. Additionally, phylogenies were inferred from the mitochondrially encoded cytochromecoxidase I gene (MT-CO1). Details of the helminth surface, such as the oral aperture, cephalic papillae, papillae in the posterior region of the body and longitudinal cuticular elements represented by spine-like projections and fans are presented, adding new taxonomic details. Molecular phylogenetic analysis, based on the MT-CO1, demonstrated thatP. (P.)zygodontomisandPterygodermatites (Paucipectines) jaegerskioldiform a unique evolutionary unit in accordance with the subgenusPaucipectinesand corroborated their occurrence in cricetid and didelphid hosts.
Subjective Cognitive Decline Modifies the Relationship Between Cerebral Blood Flow and Memory Function in Cognitively Normal Older Adults
Authors: Hays Chelsea C. , Zlatar Zvinka Z. , Campbell Laura , Meloy M.J. , Wierenga Christina E. 
Published: October 2017

AbstractObjectives: Subjective cognitive decline (SCD), or self-reported cognitive decline despite normal neuropsychological test performance, is a risk factor for objective cognitive decline and Alzheimer’s disease (AD). While brain mechanisms contributing to SCD are not well defined, studies show associations with vascular risk factors and altered cerebral blood flow (CBF), raising the hypothesis that those with SCD might be experiencing vascular dysregulation, or a disruption in the normal relationship between CBF and cognition. We examined whether the association between CBF and verbal memory performance differs between those with SCD (SCD+) and those without SCD (SCD-). Methods: Linear mixed-effects models were used to investigate whether the voxel-wise relationship between arterial spin labeling (ASL) MRI-measured CBF and verbal memory performance was modified by SCD among a group of 70 cognitively normal older adults (35 SCD+, 35 SCD-; mean age=72) matched on age, gender, and symptoms of depression. Results: Results indicated that the SCD- group exhibited positive associations between verbal memory and CBF within the posterior cingulate cortex, middle temporal gyrus, and inferior frontal gyrus, whereas the SCD+ group displayed negative associations between verbal memory and CBF within the posterior cingulate cortex, middle temporal gyrus, hippocampus, fusiform gyrus, and inferior frontal gyrus. Conclusions: Findings suggest that, while higher CBF is supportive of memory function in those without SCD, higher CBF may no longer support memory function in those presenting with SCD, perhaps reflecting neurovascular dysregulation. (JINS, 2018, 24, 213–223)
Associations Between Asthma and Sensitization to Pet or Pollen Allergens in Young Swedish Twins – The STOPPA Study
Authors: Lindemalm Cecilia , Nordlund Björn , Örtqvist Anne K. , Lundholm Cecilia , van Hage Marianne , Gong Tong , Almqvist Catarina 
Published: October 2017

Background: An association between childhood asthma and IgE sensitization has been established, but our understanding of the genetic and environmental contribution to it is incomplete. Our aim was to estimate the associations and dose-response relationship between asthma and sensitization to airborne allergens in Swedish 9- to 14-year-old twins. Additionally, we aimed to explore the importance of familial confounding from shared genes and environment using co-twin controls.Methods: In the STOPPA cohort, 752 same-sex twin children were screened with Phadiatop® (Thermo Fisher Scientific; Pharmacia, Uppsala, Sweden); if positive further analysis of IgE antibodies to airborne allergens of pets (cat, horse, dog), pollens (birch, timothy, mugwort), mites, and mold were performed. The associations between asthma and airborne allergens were assessed with generalized estimating equations. The co-twin control analysis was performed by conditional logistic regression.Results: Children with positive Phadiatop® had more than doubled odds of asthma (OR 2.53, 95% CI [1.74, 3.70]). Sensitization to pet allergens was associated with increased odds of asthma; for example, cat OR 4.15 (95% CI [2.67, 6.45]), with similar estimates for pollens; for example, birch OR 3.22 (95% CI [2.12, 4.91]). Associations persisted with sensitization as a categorical variable and for trend, indicating a dose-response relationship. Results remained in the co-twin analyses; for example, cat OR 4.75 (95% CI [1.62, 14.0]) and birch OR 5.00 (95% CI [1.45, 17.3]).Conclusion: The association between childhood asthma and sensitization to airborne allergens remains in co-twin analyses, indicating they are not due to confounding from shared environmental or genetic factors.
Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
Authors: Llorente Cristina , Jepsen Peter , Inamine Tatsuo , Wang Lirui , Bluemel Sena , Wang Hui J. , Loomba Rohit , Bajaj Jasmohan S. , Schubert Mitchell L. , Sikaroodi Masoumeh , Gillevet Patrick M. , Xu Jun , Kisseleva Tatiana , Ho Samuel B. , DePew Jessica , Du Xin , Sørensen Henrik T. , Vilstrup Hendrik , Nelson Karen E. , Brenner David A. , Fouts Derrick E. , Schnabl Bernd 
Published: October 2017

AbstractChronic liver disease is rising in western countries and liver cirrhosis is the 12th leading cause of death worldwide. Simultaneously, use of gastric acid suppressive medications is increasing. Here, we show that proton pump inhibitors promote progression of alcoholic liver disease, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis in mice by increasing numbers of intestinal Enterococcus spp. Translocating enterococci lead to hepatic inflammation and hepatocyte death. Expansion of intestinal Enterococcus faecalis is sufficient to exacerbate ethanol-induced liver disease in mice. Proton pump inhibitor use increases the risk of developing alcoholic liver disease among alcohol-dependent patients. Reduction of gastric acid secretion therefore appears to promote overgrowth of intestinal Enterococcus, which promotes liver disease, based on data from mouse models and humans. Recent increases in the use of gastric acid-suppressive medications might contribute to the increasing incidence of chronic liver disease.
Control of chrysanthemum flowering through integration with an aging pathway
Authors: Wei Qian , Ma Chao , Xu Yanjie , Wang Tianle , Chen Yiyu , Lü Jing , Zhang Lili , Jiang Cai-Zhong , Hong Bo , Gao Junping 
Published: October 2017

AbstractAge, as a threshold of floral competence acquisition, prevents precocious flowering when there is insufficient biomass, and ensures flowering independent of environmental conditions; however, the underlying regulatory mechanisms are largely unknown. In this study, silencing the expression of a nuclear factor gene, CmNF-YB8, from the short day plant chrysanthemum (Chrysanthemum morifolium), results in precocious transition from juvenile to adult, as well as early flowering, regardless of day length conditions. The expression of SQUAMOSA PROMOTER BINDING-LIKE (SPL) family members, SPL3, SPL5, and SPL9, is upregulated in CmNF-YB8-RNAi plants, while expression of the microRNA, cmo-MIR156, is downregulated. In addition, CmNF-YB8 is shown to bind to the promoter of the cmo-MIR156 gene. Ectopic expression of cmo-miR156, using a virus-based microRNA expression system, restores the early flowering phenotype caused by CmNF-YB8 silencing. These results show that CmNF-YB8 influences flowering time through directly regulating the expression of cmo-MIR156 in the aging pathway.
Plume-subduction interaction forms large auriferous provinces
Authors: Tassara Santiago , González-Jiménez José M. , Reich Martin , Schilling Manuel E. , Morata Diego , Begg Graham , Saunders Edward , Griffin William L. , O’Reilly Suzanne Y. , Grégoire Michel , Barra Fernando , Corgne Alexandre 
Published: October 2017

AbstractGold enrichment at the crustal or mantle source has been proposed as a key ingredient in the production of giant gold deposits and districts. However, the lithospheric-scale processes controlling gold endowment in a given metallogenic province remain unclear. Here we provide the first direct evidence of native gold in the mantle beneath the Deseado Massif in Patagonia that links an enriched mantle source to the occurrence of a large auriferous province in the overlying crust. A precursor stage of mantle refertilisation by plume-derived melts generated a gold-rich mantle source during the Early Jurassic. The interplay of this enriched mantle domain and subduction-related fluids released during the Middle-Late Jurassic resulted in optimal conditions to produce the ore-forming magmas that generated the gold deposits. Our study highlights that refertilisation of the subcontinental lithospheric mantle is a key factor in forming large metallogenic provinces in the Earth’s crust, thus providing an alternative view to current crust-related enrichment models.
Microfluidics with fluid walls
Authors: Walsh Edmond J. , Feuerborn Alexander , Wheeler James H. R. , Tan Ann Na , Durham William M. , Foster Kevin R. , Cook Peter R. 
Published: October 2017

AbstractMicrofluidics has great potential, but the complexity of fabricating and operating devices has limited its use. Here we describe a method — Freestyle Fluidics — that overcomes many key limitations. In this method, liquids are confined by fluid (not solid) walls. Aqueous circuits with any 2D shape are printed in seconds on plastic or glass Petri dishes; then, interfacial forces pin liquids to substrates, and overlaying an immiscible liquid prevents evaporation. Confining fluid walls are pliant and resilient; they self-heal when liquids are pipetted through them. We drive flow through a wide range of circuits passively by manipulating surface tension and hydrostatic pressure, and actively using external pumps. Finally, we validate the technology with two challenging applications — triggering an inflammatory response in human cells and chemotaxis in bacterial biofilms. This approach provides a powerful and versatile alternative to traditional microfluidics.
Gravitational-wave localization alone can probe origin of stellar-mass black hole mergers
Authors: Bartos I. , Haiman Z. , Marka Z. , Metzger B. D. , Stone N. C. , Marka S. 
Published: October 2017

AbstractThe recent discovery of gravitational waves from stellar-mass binary black hole mergers by the Laser Interferometer Gravitational-wave Observatory opened the door to alternative probes of stellar and galactic evolution, cosmology and fundamental physics. Probing the origin of binary black hole mergers will be difficult due to the expected lack of electromagnetic emission and limited localization accuracy. Associations with rare host galaxy types—such as active galactic nuclei—can nevertheless be identified statistically through spatial correlation. Here we establish the feasibility of statistically proving the connection between binary black hole mergers and active galactic nuclei as hosts, even if only a sub-population of mergers originate from active galactic nuclei. Our results are the demonstration that the limited localization of gravitational waves, previously written off as not useful to distinguish progenitor channels, can in fact contribute key information, broadening the range of astrophysical questions probed by binary black hole observations.
Cenozoic global cooling and increased seawater Mg/Ca via reduced reverse weathering
Authors: Dunlea Ann G. , Murray Richard W. , Santiago Ramos Danielle P. , Higgins John A. 
Published: October 2017

AbstractAuthigenic clay minerals formed on or in the seafloor occur in every type of marine sediment. They are recognized to be a major sink of many elements in the ocean but are difficult to study directly due to dilution by detrital clay minerals. The extremely low dust fluxes and marine sedimentation rates in the South Pacific Gyre (SPG) provide a unique opportunity to examine relatively undiluted authigenic clay. Here, using Mg isotopes and element concentrations combined with multivariate statistical modeling, we fingerprint and quantify the abundance of authigenic clay within SPG sediment. Key reactants include volcanic ash (source of reactive aluminium) and reactive biogenic silica on or shallowly buried within the seafloor. Our results, together with previous studies, suggest that global reorganizations of biogenic silica burial over the Cenozoic reduced marine authigenic clay formation, contributing to the rise in seawater Mg/Ca and decline in atmospheric CO2 over the past 50 million years.
Pan-Antarctic analysis aggregating spatial estimates of Adélie penguin abundance reveals robust dynamics despite stochastic noise
Authors: Che-Castaldo Christian , Jenouvrier Stephanie , Youngflesh Casey , Shoemaker Kevin T. , Humphries Grant , McDowall Philip , Landrum Laura , Holland Marika M. , Li Yun , Ji Rubao , Lynch Heather J. 
Published: October 2017

AbstractColonially-breeding seabirds have long served as indicator species for the health of the oceans on which they depend. Abundance and breeding data are repeatedly collected at fixed study sites in the hopes that changes in abundance and productivity may be useful for adaptive management of marine resources, but their suitability for this purpose is often unknown. To address this, we fit a Bayesian population dynamics model that includes process and observation error to all known Adélie penguin abundance data (1982–2015) in the Antarctic, covering >95% of their population globally. We find that process error exceeds observation error in this system, and that continent-wide “year effects” strongly influence population growth rates. Our findings have important implications for the use of Adélie penguins in Southern Ocean feedback management, and suggest that aggregating abundance across space provides the fastest reliable signal of true population change for species whose dynamics are driven by stochastic processes.
Erratum: Laparoscopic versus opengastric surgery for the treatment of pathological T1N0M0 gastric cancer in elderly patients: a matched study
Authors: Pan Haiyan , Li Tao , Huang Zhigang , Yu Haibing , Kong Danli , Ding Yuanlin , Pan Congcong , Jiang Yugang 
Published: October 2017

AbstractA correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
Complement Protein C3 Suppresses Axon Growth and Promotes Neuron Loss
Authors: Peterson Sheri L. , Nguyen Hal X. , Mendez Oscar A. , Anderson Aileen J. 
Published: October 2017

AbstractThe inflammatory response to spinal cord injury (SCI) involves localization and activation of innate and adaptive immune cells and proteins, including the complement cascade. Complement C3 is important for the classical, alternative, and lectin pathways of complement activation, and its cleavage products C3a and C3b mediate several functions in the context of inflammation, but little is known about the potential functions of C3 on regeneration and survival of injured neurons after SCI. We report that 6 weeks after dorsal hemisection with peripheral conditioning lesion, C3−/−mice demonstrated a 2-fold increase in sensory axon regeneration in the spinal cord in comparison to wildtype C3+/+mice.In vitro, addition of C3 tripled both myelin-mediated neurite outgrowth inhibition and neuron loss versus myelin alone, and ELISA experiments revealed that myelin serine proteases cleave C3 to generate active fragments. Addition of purified C3 cleavage products to cultured neurons suggested that C3b is responsible for the growth inhibitory and neurotoxic or anti-adhesion activities of C3. These data indicate that C3 reduces neurite outgrowth and neuronal viabilityin vitroand restricts axon regenerationin vivo, and demonstrate a novel, non-traditional role for this inflammatory protein in the central nervous system.
Magnetic Nanoparticle-Reduced Graphene Oxide Nanocomposite as a Novel Bioelectrode for Mediatorless-Membraneless Glucose Enzymatic Biofuel Cells
Authors: Pakapongpan Saithip , Tuantranont Adisorn , Poo-arporn Rungtiva P. 
Published: October 2017

AbstractIn this work, an enzymatic biofuel cell (EBC) based on a membraneless and mediatorless glucose enzymatic fuel cell system was constructed for operation in physiological conditions (pH 7.0 and temperature 37 °C). The new platform EBC made of nanocomposite, including magnetic nanoparticles (Fe3O4 NPs) and reduced graphene oxide (RGO), was used for the immobilization of glucose oxidase (GOD) as bioanode and bilirubin oxidase (BOD) as biocathode. The EBC bioelectrodes were fabricated without binder or adhesive agents for immobilized enzyme and the first EBC using superparamagnetic properties with Fe3O4 NPs has been reported. The performance of the EBC was evaluated with promising results. In EBC tests, the maximum power density of the EBC was 73.7 μW cm−2 and an open circuit voltage (OCV) as +0.63 V with 5 mM of glucose concentration for the physiological condition of humans. The Fe3O4-RGO nanocomposite offers remarkable enhancement in large surface areas, is a favorable environment for enzyme immobilization, and facilitates electron transfer between enzymes and electrode surfaces. Fe3O4 and RGO have been implied as new promising composite nanomaterials for immobilizing enzymes and efficient platforms due to their superparamagnetism properties. Thus, glucose EBCs could potentially be used as self-powered biosensors or electric power sources for biomedical device applications.
Reconstruction of non-error magnetic hologram data by magnetic assist recording
Authors: Shirakashi Zen , Goto Taichi , Takagi Hiroyuki , Nakamura Yuichi , Lim Pang Boey , Uchida Hironaga , Inoue Mitsuteru 
Published: October 2017

AbstractHologram memory is expected to be the next-generation of optical data storage technology. Bismuth-substituted yttrium iron garnet is typically used for rewritable magnetic hologram media. The diffraction efficiency of magnetic holography depends on the Faraday rotation angle, but the experimental diffraction efficiency is not as high as that expected from calculations. This difference could be caused by incomplete magnetization reversal at the recorded region. In this study, we investigated the effects of magnetic assist (MA) recording through numerical simulation and experiment to improve the diffraction efficiency and the resulting reconstructed images. The improvement of diffraction efficiency was more effective in garnet films thinner than the width of a fringe, and a suitable value of the assist magnetic field was identified for the improvement. In addition, MA recording improved the intensity of reconstructed images and broadened the non-error recording conditions to the low energy region. This technique shows promise in improving the reconstructed quality of magnetic hologram data.
Response of human periodontal ligament stem cells to IFN-γ and TLR-agonists
Authors: Andrukhov Oleh , Hong Johanna Sang-A , Andrukhova Olena , Blufstein Alice , Moritz Andreas , Rausch-Fan Xiaohui 
Published: October 2017

AbstractPeriodontal ligament stem cells similarly to the mesenchymal stem cells of other tissues possess immunomodulatory properties, which are regulated by different cytokines, particularly by interferon-γ (IFN-γ). In contrast, less information is provided about the effect of toll-like receptors ligand on immunomodulatory properties of these cells. In the present study we investigated the response of human periodontal ligament stem cells (hPDLSCs) in response to simultaneous stimulation with IFN-γ and toll-like receptor (TLR) agonists. The resulting expression of indoleamine-2,3-dioxygenase-1 (IDO-1), interleukin (IL)-6, IL-8 and monocyte chemotactic protein 1 (MCP-1) was investigated. The expression of IDO-1 was upregulated by IFN-γ in both gene and protein levels. TLR2 agonists Pam3CSK4 induced gene expression of IDO-1, but had no effect on protein expression. IFN-γ induced IDO-1 protein expression was further enhanced by Pam3CSK4. TLR-4 agonist E. coli LPS has no significant effect on neither basal nor IFN-γ induced IDO-1 protein expression. The production of IL-6, IL-8, and MCP-1 was induced by TLR agonists. Neither basal nor TLR agonists induced production of these proteins was affected by IFN-γ. Our data shows potential interaction between IFN-γ and TLR2 responses in hPDLSCs, which might be involved in regulation of immune response in inflammatory diseases, and particularly periodontitis.
Store-operated Ca2+ Entry Facilitates the Lipopolysaccharide-induced Cyclooxygenase-2 Expression in Gastric Cancer Cells
Authors: Wong Jhen-Hong , Ho Kuo-Hao , Nam Sean , Hsu Wen-Li , Lin Chia-Hsien , Chang Che-Mai , Wang Jaw-Yuan , Chang Wei-Chiao 
Published: October 2017

AbstractHelicobacter pylori has been identified as one of the major causes of chronic gastritis, gastric and duodenal ulcers, and gastric cancer. Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria, and H. pylori LPS might play an exclusively important role in activating inflammatory pathways in monocytes and macrophages. To study the role of LPS in the underlying mechanism of inflammatory responses, we established an in vitro model using the human AGS gastric cancer cell line. We found that LPS mediates inflammation through setting off a cascade of events: activation of the store-operated calcium (SOC) channel, initiation of downstream NF-κB signaling, and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). Phosphorylated ERK1/2 promotes the nuclear translocation of NF-κB, and eventually elevates the expression level of COX-2, a major inflammatory gene.
A minimal resting time of 25 min is needed before measuring stabilized blood pressure in subjects addressed for vascular investigations
Authors: Mahe Guillaume , Comets Emmanuelle , Nouni Aziz , Paillard François , Dourmap Caroline , Le Faucheur Alexis , Jaquinandi Vincent 
Published: October 2017

AbstractBlood pressure (BP) measurement is a central element in clinical practice. According to international recommendations 3 to 5 minutes of resting is needed before blood pressure measurement. Surprisingly, no study has modelled the time course of BP decrease and the minimum resting-time before BP measurement. A cross-sectional bicentric observational study was performed including outpatients addressed for vascular examination. Using two automatic BP monitors we recorded the blood pressure every minute during 11 consecutive minutes. The data was analyzed by non-linear mixed effect regression. Systolic (SBP) and diastolic BPs were studied and we tested the effect of covariates on its evolution through log-likelihood ratio tests. We included 199 patients (66+/−13years old). SBP was found to decrease exponentially. Simulations based on the final model show that only half the population reaches a stabilized SBP (defined as SBP + 5 mmHg) after 5 min of resting-time while it takes 25 min to ensure 90% of the population has a stabilized SBP. In conclusion, our results and simulations suggest that 5 minutes are not enough to achieve a stabilized SBP in most patients and at least 25 minutes are required. This questions whether the diagnosis of hypertension can be reliably made during routine visits in general practitioners’ offices.