bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Did Latino Family Caregivers Expect and Learn From Education Intervention “Caregivers Like Me”?
Authors: Cruz-Oliver Dulce M. , Parikh Manas , Wallace Cara L. , Malmstrom Theodore K. , Sanchez-Reilly Sandra 
Published: November 2017

Objective: US Latinos historically have underutilized end-of-life (EOL) resources. This study reports the views of family caregivers before and after education intervention Caregivers Like Me geared to improve knowledge and attitudes regarding EOL resources among Latino caregivers. Methods: This is a qualitative substudy within a multicentered cross-sectional study design. Educational intervention was offered to family caregivers of Latino elders from 3 different communities, using an audiovisual presentation, including a case-based video telenovela and pre–posttest questionnaires with open-ended questions. This study pertains to the qualitative results for the open-ended questions before and after education intervention. Results: Participants (N = 145) were mostly females (79%) with a mean age of 56 ± 15 years and reported (92%) active learning from intervention. The pretest open-ended question on expected learning identified 2 themes, care for the sick and self-care. It included 5 subthemes and the most common one was how to help the sick. The posttest question on actual learning identified the same 2 themes and 4 subthemes that were similar but different from the pretest. Accepting help and knowledge of services available were the most common. Conclusion: The education intervention Caregivers Like Me was able to improve attitudes toward EOL care because participants who wanted to help their loved ones realized that they need to accept professional help and were made aware of the services available.
Patient Outcomes After Palliative Care Consultation Among Patients Undergoing Therapeutic Hypothermia
Authors: Pinto Priya , Brown Tartania , Khilkin Michael , Chuang Elizabeth 
Published: November 2017

Objectives: To compare the clinical outcomes of patients who did and did not receive palliative care consultation among those who experienced out-of-hospital cardiac arrest and underwent therapeutic hypothermia. Methods: We identified patients at a single academic medical center who had undergone therapeutic hypothermia after out-of-hospital cardiac arrest between 2009 and 2013. We performed a retrospective chart review for demographic data, hospital and critical care length of stay, and clinical outcomes of care. Results: We reviewed the charts of 62 patients, of which 35 (56%) received a palliative care consultation and 27 (44%) did not. Palliative care consultation occurred an average of 8.3 days after admission. Patients receiving palliative care consultation were more likely to have a do-not-resuscitate (DNR) order placed (odds ratio: 2.3, P < .001). The mean length of stay in the hospital was similar for patients seen by palliative care or not (16.7 vs 17.1 days, P = .90). Intensive care length of stay was also similar (11.3 vs 12.6 days, P = .55). Conclusions: Palliative care consultation was underutilized and utilized late in this cohort. Palliative consultation was associated with DNR orders but did not affect measures of utilization such as hospital and intensive care length of stay.
Monomethyl fumarate treatment impairs maturation of human myeloid dendritic cells and their ability to activate T cells
Authors: Mazzola Maria Antonietta , Raheja Radhika , Regev Keren , Beynon Vanessa , von Glehn Felipe , Paul Anu , Pierre Isabelle , Kivisakk Pia , Weiner Howard L , Gandhi Roopali 
Published: November 2017

Background: Dimethyl fumarate (DMF) and its active metabolite monomethyl fumarate (MMF) effectively lead to reduction in disease relapses and active magnetic resonance imaging (MRI) lesions. DMF and MMF are known to be effective in modulating T- and B-cell responses; however, their effect on the phenotype and function of human myeloid dendritic cells (mDCs) is not fully understood. Objective: To investigate the role of MMF on human mDCs maturation and function. Methods: mDCs from healthy controls were isolated and cultured in vitro with MMF. The effect of MMF on mDC gene expression was determined by polymerase chain reaction (PCR) array after in vitro MMF treatment. The ability of mDCs to activate T cells was assessed by in vitro co-culture system. mDCs from DMF-treated multiple sclerosis (MS) patients were analyzed by flow cytometry and PCR. Results: MMF treatment induced a less mature phenotype of mDCs with reduced expression of major histocompatibility complex class II (MHC-II), co-stimulatory molecules CD86, CD40, CD83, and expression of nuclear factor κB (NF-κB) subunits RELA and RELB. mDCs from DMF-treated MS patients also showed the same immature phenotype. T cells co-cultured with MMF-treated mDCs showed reduced proliferation with decreased production of interferon gamma (IFN-γ), interleukin-17 (IL-17), and granulocyte-macrophage colony-stimulating factor (GM-CSF) compared to untreated cells. Conclusion: We report that MMF can modulate immune response by affecting human mDC function.
Comparison of CTA and DSA in the diagnosis of superior mesenteric artery dissecting aneurysm
Authors: Jia Zhongzhi , Huang Youhua , Shi Hongjian , Tang Liming , Shi Haifeng , Qian Liulan , Jiang Guomin 
Published: November 2017

Objective To compare computed tomography arteriography (CTA) and digital subtraction arteriography (DSA) in the diagnosis of superior mesenteric artery dissecting aneurysm (SMADA). Methods All SMADA patients who underwent CTA and DSA at one of two medical centers between May, 2007 and April, 2017 were identified. The accuracy of CTA and DSA for the depiction of morphologic characteristics of SMADA was analyzed. Results Fourteen patients (12 men; mean age, 55.1 ± 6.4 years) were included in this study. The mean diameter of the dissecting aneurysm was 3.78 ± 1.53 mm on CTA and 3.81 ± 1.54 mm on DSA ( p = 0.96). The luminal stenosis was 0.52 ± 0.27 on CTA and 0.35 ± 0.23 on DSA ( p = 0.09). The thrombosed false lumen was visualized on CTA in 79% (11/14) of patients but in no patients on DSA ( p < 0.001). The entry points of the dissection were visualized on CTA in 64.3% (9/14) of patients and on DSA in 100% (14/14) of patients ( p = 0.041); CTA and DSA did not visualize re-entry points in any patients. The intimal flap was visualized on CTA in 71.4% (10/14) of patients and on DSA in 78.6% (11/14) of patients ( p > 0.05). Branch vessel involvement was visualized in 7.1% (1/14) of patients on CTA but in no patients on DSA ( p > 0.05). Conclusions CTA can be used in place of DSA for the diagnosis of SMADA. Although CTA may exaggerate the degree of luminal stenosis and is weak in depicting the entry points of SMADA, this modality more accurately depicts the thrombosed false lumen and branch vessel involvement.
НЕЙРОСЕТЕВАЯ ДИАГНОСТИКА И ПРОГНОЗИРОВАНИЕ ВОЗРАСТА ВОЗНИКНОВЕНИЯ ПАНКРЕАТИТА НА ОСНОВЕ АНАЛИЗА ФАКТОРОВ РИСКА
Authors: Lazarenko Viktor Anatolevich , Antonov Andrey Evgenevich , Prasolov Aleksandr Vladimirovich 
Published: November 2017

Цель. В социально-гигиеническом исследовании разработать искусственную нейронную сеть, предназначенную для диагностики панкреатита и прогнозирования времени его наступления на основе анализа сведений о факторах риска, а также провести апробацию программы в клинической практике.Материалы и методы. Исследование проведено по материалам 488 больных (из них 167 с панкреатитом), проходивших стационарное лечение в городе Курске по поводу заболеваний гепатопанкреатодуоденальной зоны. Обработка информации о факторах риска здоровью (возрастно-половой принадлежности, вредных привычках, стрессах, профессиональном и семейном анамнезе, ранее проводимом лечении) производилась с применением программного комплекса собственной разработки – «Системы интеллектуального анализа и диагностики заболеваний» (свидетельство № 2017613090).Результаты. Предложен новый подход к диагностике и прогнозированию панкреатита на основе нейросетевого анализа данных о факторах риска. Показатели чувствительности и специфичности такого метода, находились на уровне (76,74%, m = 4,16) и (90%, m = 2,96), соответственно. Ошибка прогноза возраста вероятной госпитализации не превышала 2,87 и 3,02 года (p = 0,95 и p = 0,99, соответственно). При этом система демонстрировала дополнительные преимущества: неинвазивность, низкие требования к оборудованию и профессиональной подготовке медработника, возможность оценивать результат с момента возникновения заболевания.Заключение. Эффективность предложенного подхода подтверждена на этапе клинической апробации уровнями чувствительности и специфичности, соответствующими аналогичным показателям традиционных диагностических методов – ультразвукового исследования, компьютерной томографии и определения уровней α-амилазы и липазы.
Pricing with Prescheduled Sales
Authors: Sinitsyn Maxim 
Published: November 2017

In this paper, I introduce a framework of price promotions by firms that preschedule their sale dates. I set up a dynamic model of demand accumulation in which high- and low-valuation consumers enter the market every period. The high-valuation consumers buy immediately and leave the market; the low-valuation consumers accumulate while waiting for the sale price. The firms schedule the dates of their promotions in advance. I find that often they use mixed strategies, choosing the future promotion period according to a probability distribution function. If the firms can cancel their prescheduled sales, typically they can wait longer until holding sales by shifting the probability distribution towards later periods. Scheduling promotions in advance increases the firms’ profits in comparison to the case when the promotion decision is made in the period when the promotion is offered. Data and the online appendix are available at https://doi.org/10.1287/mksc.2017.1052 .
Texto e imagen ¿antinomias? El libro-álbum como punto de encuentro.
Authors: Sánchez Lorena 
Published: November 2017

Una experiencia socializadora que permite replantear nuestras prácticas docentes, en torno a lecturas multimodales como la que propone un objeto cutural tan magnífico como lo es el libro-álbum. Voces de especialistas, de alumnos, de docentes, florecen página a página para ampliar la mirada en torno a la relación del libro-álbum como objeto artístico, puesto en circulación dentro del aula.
Pengaruh Post Weld Heat Treatment (Pwht) dengan Pemanas Induksi Terhadap Sifat Mekanik dan Struktur Mikro Sambungan Las Shield Metal Arc Welding (Smaw) pada Pipa API 5l X52
Authors: Haryadi Gunawan Dwi , Ismail Rifky , Haira Mahmuda 
Published: November 2017

Saluran perpipaan telah digunakan sebagai salah satu metode yang paling praktis dan berharga murah untuk transportasi minyak dan gas. Penyambungan pipa sendiri dilakukan dengan proses pengelasan. Pada pengelasan memunculkan efek pemanasan setempat dengan temperatur tinggi yang menyebabkan logam mengalami ekspansi termal maupun penyusutan saat pendinginan. Hal itu menyebabkan terjadinya tegangan sisa, perubahan struktur mikro, kekerasan dan ketangguhan yang berbeda-beda pada tiap-tiap daerah konstruksi. Salah satu cara untuk memperbaiki hal tersebut yaitu dengan cara melakukan post weld heat treatment (PWHT). Penelitian ini bertujuan untuk mengetahui pengaruh PWHT terhadap sifat mekanik dan struktur mikro pada pengelasan shield metal arc welding (SMAW). PWHT dilakukan dengan menggunakan alat pemanas induksi pada temperatur 400ºC, 500 ºC 600 ºC, 700 ºC dan 800 ºC dengan holding time selama 15 detik dan didinginkan di udara terbuka. Selanjutnya dilakukan pengujian impak, kekerasan dan struktur mikro untuk mengetahui pengaruh PWHT yang dilakukan. Dari hasil pengujian impak dan kekerarasan diketahui bahwa semakin tinggi temperature PWHT maka semakin tinggi juga nilai ketangguhan dan semakin menurun nilai kekerasannya. Dan dari pengamatan struktur mikro daerah weld metal PWHT mengakibatkan terjadinya peningkatan jumlah struktur acicular ferrite dan penurunan jumlah struktur widmanstatten ferrite.
Perancangan Poros Turbin 5 Mw untuk Pembangkit Listrik Tenaga Panas Bumi
Authors: Widodo Achmad , A. Kriscahya R. , Satrijo Djoeli 
Published: November 2017

Poros turbin merupakan komponen utama turbin uap pada pembangkit listrik tenaga panas bumi yang berperan untuk mentransmisikan daya atau torsi ke poros generator yang terhubung padanya. Poros turbin didesain untuk mampu menerima beban-beban poros saat poros beroperasi fluktuasi daya pada siklus tertentu. Material yang digunakan pada poros adalah stainless steel karena poros bekerja pada kondisi lingkungan korosif. Tujuan penelitian ini adalah untuk menghasilkan desain poros yang memenuhi persyaratan kelayakan desain berupa ASME Code: Design of Transmission Shaft, AS1170.1, ANSI B4.1-1978 dan aman dalam menerima beban statik maupun dinamik. Perangkat lunak yang digunakan untuk memodelkan dan analisis poros adalah Solidworks 2015 dan ANSYS 16. Konsep desain terdiri dari 6 model poros dengan variasi fillet dengan material Stainless Steel jenis AISI 410. Model poros 6 adalah desain poros yang dipilih karena tegangan Von Mises poros 124,49 MPa dengan faktor keamanan statik 2,48 dan tegangan geser maksimumnya senilai 66,01 MPa sudah memenuhi syarat kode ASME. Defleksi poros sebesar 1,3 mm memenuhi persyaratan AS1170.1 dengan ukuran interferensi radial yang digunakan sebesar 0,2 mm sesuai dengan ANSI B4.1-1978. Faktor keamanan lelah (fatigue) poros dari awal operasi sampai overhaul adalah 0,81. Meskipun demikian, diagram S-N menunjukkan bahwa umur poros berdasarkan siklus dari awal operasi sampai overhaul mencapai 2,9 x 105 siklus.
Effects of age and education on variable but native heritage grammars: Theoretical and empirical implications for the Null Subject Parameter
Authors: Schmitz Katrin , Scherger Anna-Lena 
Published: November 2017

AbstractIn this contribution, we investigate the impact of language-internal and language-external factors on the parametrized grammatical domain of (null) subjects in adult Italian heritage speakers (HS, n=16). Based on empirical evidence from correlation analyses comparing these speakers´ spontaneous speech to monolingual Italians (n=10), we determine the kind and extent of variation in monolingual and bilingual adult end-state grammars. We will show that there is indeed a significant variation in the null subject production of the HS related to the factorsageandeducationwhich is, however, constrained to contexts of 1stgrammatical person. This observation cannot be taken to represent incomplete acquisition but rather a discourse and possibly situation-related competent behaviour. We propose that end-state HS grammars are characterized by a full grammatical and pragmatic competence, combined with a larger variation of language-externally determined preferences than monolinguals show. This does not call the native end-state competence of HS into question but opens the door for potential changes in future bilingual generations. We further discuss the implications for language acquisition theory and language change in terms of stability.
Possibilities and limitations of individual-tree growth models – A review on model evaluations
Authors: Vospernik Sonja 
Published: November 2017

SummaryIndividual-tree growth models are the new standard for modeling growth and yield. Their main purpose is to simulate future forest management scenarios but they can also be used to predict wood quality, rockfall protection or habitat quality. Individual tree growth models may consist of different models but core models are diameter increment, height increment, crown ratio (often used as a predictor for increment) and mortality. The model differentiation is based on how these four models include tree age (size), competition and site. Four common growth simulators in Central Europe are BWIN, Moses, Prognaus and Silva. These four models are commonly deployed to simulate 30 years of growth, but a prospective application is the simulation of a whole rotation period (80–150 years). It is therefore crucial to understand the possibilities and limitations of these models by evaluating them. This review paper summarizes the statistical and emergent properties’ evaluation results for these models. Statistical evaluations focus on individual models of a simulator, whereas the evaluation of emergent properties evaluates the entire simulator, by testing if the models conform to known principles of stand growth. Further, the meaning of these evaluation results for the development and improvement of individual-tree growth models is discussed.
Comprehensive spectroscopic (FT-IR, FT-Raman, 1H and 13C NMR) identification and computational studies on 1-acetyl-1H-indole-2,3-dione
Authors: Almutairi Maha S. , Muthu S. , Prasana Johanan C. , Chandralekha B. , Al-Ghamdi Alwah R. , Attia Mohamed I. 
Published: November 2017

AbstractFourier transform infrared (FT-IR) and FT-Raman spectra of 1-acetyl-1H-indole-2,3-dione (N-acetylisatin) were recorded in the solid phase and analyzed. The molecular geometry, vibrational frequencies, infrared intensities, Raman activities and atomic charges were calculated using density functional theory (DFT/B3LYP) calculations with a standard 6-311++G(d,p) basis set. The fundamental vibrational modes of N-acetylisatin were analyzed and fully assigned with the aid of the recorded FT-IR and FT-Raman spectra. The simulated FT-IR and FT-Raman spectra showed good agreement with the experimental spectra. The stability of the molecule, arising from hyper-conjugative interactions and charge delocalization, was analyzed using natural bond orbital (NBO) analysis. The dipole moment (µ), polarization (α) and hyperpolarization (β) values of N-acetylisatin were also computed. The potential energy distribution (PED) was computed for the assignment of unambiguous vibrational fundamental modes. The HOMO and LUMO energy gap illustrated the chemical activity of N-acetylisatin. The energy and oscillator strength were calculated by DFT. Gauge–including atomic orbital NMR (1H and 13C) chemical shift calculations were performed and compared with the experimental values. Thermodynamic properties (heat capacity, entropy and enthalpy) of the compound at different temperatures were also calculated.
Weighted integral Hankel operators with continuous spectrum
Authors: Fedele Emilio , Pushnitski Alexander 
Published: November 2017

Abstract Using the Kato-Rosenblum theorem, we describe the absolutely continuous spectrum of a class of weighted integral Hankel operators in L2(ℝ+). These self-adjoint operators generalise the explicitly diagonalisable operator with the integral kernel sαtα(s + t)-1-2α, where α > -1/2. Our analysis can be considered as an extension of J. Howland’s 1992 paper which dealt with the unweighted case, corresponding to α = 0.
Trismus and reduced quality of life in patients with oral squamous cell carcinoma, who received post-operative radiotherapy alone or combined with chemotherapy
Authors: Galitis Evangelos , Droukas Vyron , Tzakis Michail , Psarras Vassileios , Galiti Dimitra , Kyrodimos Eythymios , Trichas Miltiadis , Psyrri Amanda , Papadogeorgakis Nikolaos , Kouri Maria , Belli Evelina , Kouloulias Vasileios 
Published: November 2017

Abstract

Background
Patients, who receive radiotherapy (RT) for head and neck cancer, develop chronic functional abnormalities and survive with reduced quality of life.

Purpose
We aimed to study patients with oral cancer, who received post-operative radiotherapy or chemoradiotherapy.

Patients
Ten patients (mean age 63.8 years) were included.

Methods
Oral mucositis, pain and xerostomia, maximum mouth opening (MMO) and functional abnormalities before and after RT were recorded. The 35 mm MMO or less was accepted as trismus. Patients completed the EORTC QLQ C-30 and Head/Neck35 questionnaires.

Results
Mean RT dose was 64.3 Gray. Six patients received chemoradiotherapy. Severe mucositis, pain and xerostomia were recorded in 6 and 5 patients respectively. MMO was reduced in all patients. The mean MMO (34 mm) reached the level of trismus. The total number of symptoms increased from 3.1 to 6.3 in C-30 and from 3.1 to 8.8 per patient in the H/N35. Severe fatigue, pain, limitations at work, weakness, sad feelings, family problems, sleeping problems, anorexia, financial difficulties, tense/irritable, constipation, nausea, vomiting and depression were most often reported with C-30. Most patients reported low to moderate quality of life. Severe oral, jaw and neck pain, swallowing problems, taste alterations, sticky saliva, dry mouth, coarseness, dental problems, feeling sick and reduced interest in life/sex were the most common symptoms reported with N/H35.

Conclusions
The observed trismus, 2- to 3-fold increase of symptoms and poorer quality of life highlighted the need for support of oral cancer patients, who receive postoperative radiotherapy or chemoradiotherapy.
Targeting Bruton Tyrosine Kinase: A novel strategy in the treatment of B-cell lymphomas
Authors: Sklavenitis-Pistofidis R. , Koletsa T. , Lazaridou A. , Goulas A. 
Published: November 2017

AbstractIn normal B-cells, Bruton tyrosine kinase (Btk), a non-receptor tyrosine kinase involved in B-cell receptor (BCR) signalling, is essential for cell survival and maturation. Not surprisingly, Btk is also implicated in the pathogenesis of B-cell lymphomas, like Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma (CLL/SLL), Mantle Cell Lymphoma (MCL) and Waldenström’s Macroglobulinemia (WM), which are driven by aberrant BCR signalling. Thus, targeting Btk represents a promising therapeutic strategy in the treatment of B-cell lymphoma patients. Ibrutinib, a selective Btk inhibitor, has already been approved as second-line treatment of CLL/SLL, MCL and WM patients, while more clinical studies of ibrutinib and novel Btk inhibitors are currently under way. In light of results of the RESONATE-2 trial, the approval of ibrutinib as a first-line treatment of CLL/SLL may well be approaching. Herein, we review Btk’s role in normal and malignant BCR signalling, as well as ibrutinib’s performance in B-cell lymphoma treatment and prognosis.
The Role of Genetics in Sporadic GEP-NETs: A Comprehensive Review of the Literature
Authors: Fotopoulos George , Vathiotis Ioannis , Nikou George C. , Syrigos Konstantinos 
Published: November 2017

Abstract
Neuroendocrine tumors (NETs) are composed of a heterogeneous group of malignancies from neuroendocrine cell compartments, with roles in both the endocrine and the nervous system. The majority of NETs are gastroenteropancreatic (GEP) in origin, arising in the foregut, midgut, or hindgut. The genomic landscape of GEP-NETs has been scarcely studied in terms of genomic profiling.The following algorithm was followed using the keywords neuroendocrine, genomics, targeted therapy, personalized medicine, gastroenteropancreatic and NET. The search was performed in PubMed and ScienceDirect database. Our current knowledge of sporadic GEP-NETs genetics must be further advanced to elucidate the molecular basis and pathogenesis of the disease, improve the accuracy of diagnosis, and guide tailor-made therapies.