bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bisphenol A in Reproduction: Epigenetic Effects
Authors: Chianese Rosanna , Troisi Jacopo , Richards Sean , Scafuro Marika , Fasano Silvia , Guida Maurizio , Pierantoni Riccardo , Meccariello Rosaria 
Published: October 2017

Background:
Bisphenol A (BPA) is an endocrine disrupting chemical widely
used in the manufacture of polycarbonate plastic and epoxy resin to produce a multitude
of consumer products, food and drink containers, and medical devices. BPA is similar to
estradiol in structure and thus interferes in steroid signalling with different outcomes on
reproductive health depending on doses, life stage, mode, and timing of exposure. In this
respect, it has an emerging and controversial role as a &quot;reproductive toxicant&quot; capable of
inducing short and long-term effects including the modulation of gene expression through
epigenetic modification (i.e. methylation of CpG islands, histone modifications and production
of non-coding RNA) with direct and trans-generational effects on exposed organisms
and their offspring, respectively.

Objective:
This review provides an overview about BPA effects on reproductive health
and aims to summarize the epigenetic effects of BPA in male and female reproduction.

Results:
BPA exerts epigenetic effects in both male and female reproduction. In males,
BPA affects spermatogenesis and sperm quality and possible trans-generational effects on
the reproductive ability of the offspring. In females, BPA affects ovary, embryo development,
and gamete quality for successful in vivo and in vitro fertilization (IVF).

Conclusion:
The exact mechanisms of BPA-mediated effects in reproduction are not fully
understood; however, the environmental exposure to BPA - especially in fetal and neonatal
period - deserves attention to preserve the reproductive ability in both sexes and to reduce
the epigenetic risk for the offspring.
Anesthetic Agents and Neuronal Autophagy. What We Know and What We Don't.
Authors: Xu Lili , Shen Jianjun , McQuillan Patrick M. , Hu Zhiyong 
Published: October 2017

Background:
Ethanol is known to have both γ-Aminobutyric acid agonist and Nmethyl-
D-aspartate antagonist characteristics similar to commonly used volatile anesthetic
agents. Recent evidence demonstrates that autophagy can reduce the development of ethanol
induced neurotoxicity. Recent studies have found that general anesthesia can cause longterm
impairment of both mitochondrial morphogenesis and synaptic transmission in the developing
rat brain, both of which are accompanied by enhanced autophagy activity. Autophagy
may play an important role in general anesthetic mediated neurotoxicity.

Methods:
This review outlines the role of autophagy in the development of anesthetic related
neurotoxicity and includes an explanation of the role of autophagy in neuronal cell
survival and death, the relationship between anesthetic agents and neuronal autophagy, possible
molecular and cellular mechanisms underlying general anesthetic agent induced activation
of neuronal autophagy in the developing brain, and potential therapeutic approaches
aimed at modulating autophagic pathways.

Results:
In a time- and concentration-dependent pattern, general anesthetic agents can disrupt
intracellular calcium homeostasis which enhances both autophagy and apoptosis activation.
The degree of neural cell injury may be ultimately determined by the interplay between
autophagy and apoptosis. It appears likely that the increase in calcium flux associated with
some anesthetic agents disrupts lysosomal function. This results in an over-activation of endosomal-
lysosomal trafficking causing mitochondrial damage, reactive oxygen species upregulation,
and lipid peroxidation.

Conclusion:
Autophagy may play a role in the development of anesthetic related neurotoxicity.
Understanding this may lead to strategies or therapies aimed at preventing or ameliorating
general anesthetic agent mediated neurotoxicity.
Path analysis terhadap faktor-faktor yang mempengaruhi prestasi siswa
Authors: Caraka Rezzy Eko , Sugiarto S. 
Published: October 2017

Pendidikan merupakan aspek fundamental yang perlu diperhatikan Tujuan utama dari pendidikan adalah peningkatan kualitas sumber daya manusia (SDM) baik secara personal maupun komunal. Pencerminan dari kualitas SDM yang unggul salah satunya diindikasikan dengan pencapaian prestasi seorang individu pada saat menempuh pendidikan mulai dari tingkat dasar hingga tingkat tinggi. Prestasi belajar siswa dipengaruhi oleh faktor yang berasal dari dalam diri dan fakor yang berasal dari luar diri siswa. Faktor yang terdapat dalam diri siswa adalah intelegensi, motivasi, minat, bakat, kondisi fisik, sikap dan kebiasaan siswa. Sedangkan yang termasuk faktor yang berasal dari luar diri siswa adalah keadaan sosial ekonomi, lingkungan, sarana dan prasarana, guru dan cara mengajarnya. Pada penelitian ini digunakan analisis jalur yang merupakan bentuk modifikasi dari analisis regresi dimana variabel bebas yang diteliti tidak hanya mempengaruhi variabel terikat secara langsung, tetapi juga dapat mempengaruhi variabel tersebut secara tidak langsung. Variabel-variabel bebas tersebut memiliki pengaruh langsung dan pengaruh tak langsung terhadap variabel terikat. Berdasarkan hasil pembahasan, diperoleh kesimpulan bahwa untuk meningkatkan nilai rata-rata UN variable uang saku dan lama akses internet menjadi hal yang perlu diperhatikan oleh guru dan juga pihak lainnya yang terlibat pada pendidikan selain itu diketahui dari pengaruh tidak langsung.Kata kunci: prestasi, siswa, analisis jalur, pendidikan PATH ANALYSIS ON FACTORS INFLUENCING STUDENTS ACHIEVEMENTAbstractOn the one hand, education is a fundamental aspect to pay attention. The main purpose of education is the improvement of the quality of human resources (HR) both personal and communal. The reflection of the superior quality of human resources is indicated by the achievement of individual achievement at the time of education starting from the basic level to high level. Student achievement is influenced by factors that come from within self and that comes from outside. The factors contained within students is the intelligence, motivation, interests, talents, physical conditions, attitudes and habits. Likewise, the factors that come from outside the student is the socio-economic conditions, environment, facilities and infrastructure, teachers and how to teach. Apart from that, In this study, we used path analysis which is a modified form of regression analysis where the independent variables studied not only affect the dependent variable directly but also can affect the variable indirectly. These independent variables have a direct and indirect effect on the dependent variable. Based on the results of the discussion, it can be concluded that to increase the average of the national exam (UN) the variable of allowance and time of internet access become primary factors that need to be considered by teachers and also other parties involved in education other than it is known from indirect influence.Keywords: Achievement, Student, Path Analysis, Education
Pengaruh motivasi dan disiplin kerja terhadap kinerja guru SD di Kabupaten Cilacap
Authors: Astuti Apriliya Dwi 
Published: October 2017

Motivasi adalah hal yang menyebabkan, menyalurkan, dan mendukung perilaku manusia, supaya mau bekerja giat dan antusias mencapai hasil yang optimal. Penelitian ini bertujuan untuk menganalisis pengaruh motivasi dan disiplin kerja secara bersama-sama dan parsial terhadap kinerja guru SD di Kabupaten Cilacap. Penelitian ini termasuk penelitian ex post facto dengan pendekatan kuantitatif, penarikan sampel menggunakan Proportional Cluster Random Sampling dan Analisis data dengan Analisis regresi berganda. Berdasarkan hasil penelitian dan pembahasan dapat disimpulkan bahwa terdapat pengaruh positif motivasi secara parsial terhadap kinerja guru, disiplin kerja secara parsial tidak berpengaruh terhadap kinerja guru, dan terdapat pengaruh yang signifikan secara simultan motivasi dan disiplin kerja terhadap kinerja guru SD di Kabupaten Cilacap. Upaya meningkatkan motivasi dan displin kerja perlu dilakukan secara bersama-sama dalam meningkatkan kinerja guruKata kunci: motivasi, disisplin kerja, kinerja guru EFFECT OF MOTIVATION AND DISCIPLINE WORK ON THE PERFORMANCE OF PRIMARY SCHOOL TEACHERS IN CILACAP DISTRICTAbstractMotivation is the thing that causes, distributes, and supports human behavior, in order to work hard and enthusiastically achieve optimal results. This study aims to analyze the influence of motivation and work discipline together and partially to the performance of elementary school teachers in Cilacap regency. This research includes ex post facto research with quantitative approach, sampling using Proportional Cluster Random Sampling and Data Analysis with multiple regression analysis. Based on the results of research and discussion can be concluded that there is a positive influence of partial motivation on teacher performance, work discipline partially does not affect the performance of teachers, and there is a significant influence simultaneously motivation and work discipline on the performance of elementary school teachers in Cilacap regency. Efforts to improve motivation and work discipline need to be done jointly in improving teacher performance.Keywords: motivation, discipline work, teacher performance
Manajemen perubahan sekolah menengah kejuruan di Kabupaten Sleman
Authors: Susanto Agus , Wibowo Udik Budi 
Published: October 2017

Artikel ini bertujuan untuk mendeskripsikan pengelolaan perubahan oleh pimpinan sekolah (kepala sekolah, wakil kepala sekolah, tim) dalam perubahan peningkatan mutu. Penelitian yang dilakukan menggunakan pendekatan kualitatif dengan desain etnografi tipe mikro. Analisis data menggunakan model Spradley meliputi: analisis domain, analisis taksonomi, dan analisis komponensial. Hasil analisis menunjukkan bahwa pengelolaan perubahan pada proses perencanaan, pengorganisasian, penggerakan, pengontrolan, dan pengevaluasian menjadi tugas utama/ tanggung jawab wakil kepala sekolah bidang kurikulum beserta tim. Strategi yang digunakan adalah empiris rasional dan power sharing dengan kebijakan yang dilakukan berupa pengembangan profesionalisme guru. Nilai-nilai yang dinyakini sebagai kesuksesan dalam keberhasilan perubahan adalah kedisiplinan guru dan siswa, motivasi guru dan siswa, komitmen guru dan siswa, dan budaya akademik yang terjaga.Kata kunci: manajemen perubahan, manajemen strategik, mutu pendidikan THE CHANGE MANAGEMENT OF VOCATIONAL HIGH SCHOOL IN SLEMANAbstractThis article aims to descripe the management of change by principals, vice-principals, dan team in managing change in schools. The method used is a qualitative research design ethnography with micro ethnography type. Analysis of data using Spradley’s Model include domain analysis, analysis of taxonomic, and componential analysis. Results: the tasks of planning, organizing, actuating, controlling, and evaluating is the main task/responsibility of the vice principal and a team of curriculum areas. The strategy used is empirical and rational policy of power sharing that follow up with the professional development of teachers. The success values in the success of the change is the discipline of teacher and student, teacher and student motivation, commitment of teachers and students, academic culture is maintained.Keywords: change management, strategic management, the quality of education
Treatment changes of hypo- and hyperdivergent Class II Herbst patients
Authors: Rogers Kim , Campbell Phillip M. , Tadlock Larry , Schneiderman Emet , Buschang Peter H. 
Published: October 2017

ABSTRACT

Objectives:
To determine the relative effects of Herbst appliance therapy in hypo- and hyperdivergent patients.

Materials and Methods:
The treated group included 45 growing Class II, division 1, patients treated with stainless steel crown Herbst appliances, followed by fixed edgewise appliances. The untreated control group consisted of 45 Class II, division 1, subjects, matched to the treated sample based on Angle classification, age, sex, and pretreatment mandibular plane angle (MPA). Subjects were categorized as hypo- or hyperdivergent based on their MPAs. Pre- and posttreatment cephalograms were traced and superimposed on cranial base and mandibular structures.

Results:
The primary effect of the Herbst in terms of maxillomandibular correction was in the maxilla. It significantly restricted maxillary growth, producing a “headgear effect.” Mandibular treatment changes depended on divergence. Hyperdivergent patients experienced a deleterious backward true mandibular rotation with Herbst treatment. Hypodivergent patients, as well as untreated hypo- and hyperdivergent controls, underwent forward true mandibular rotation. However, hypodivergent chins did not advance any more than expected for untreated hypodivergent Class II patients.

Conclusions:
Hypo- and hyperdivergent patients benefit from the Herbst's headgear effect. While the mandibular growth of hypodivergent patients overcomes the negative rotational effects, hyperdivergent patients undergo a deleterious backward mandibular rotation and increases in facial height.
Deficiência física: revisão e considerações
Authors: Mendes Marcelo Simões , Canesqui Ana Maria 
Published: October 2017

A temática da deficiência física tem fomentado diferentes tipos de discussão, muitas delas oriundas da área das Ciências Biológicas ou Biomédicas, outras que privilegiam os aspectos subjetivos e socioculturais que constituem a experiência do sujeito com deficiência física. A partir de uma revisão realizada no SciELO e da inserção do termo “deficiência física”, o presente trabalho se propôs a analisar esses estudos mediante a criação de categorias temáticas e a fomentar considerações e apontamentos em cada uma dessas categorias: essas considerações partem de um olhar formado pela lente das Ciências Sociais e Humanas em Saúde. A diversidade de estudos carrega consigo a diversidade de formação dos autores e das revistas científicas em que foram publicados. As categorias analisadas envolveram desde temas que compreendem alguns tipos de avaliação até estudos em que o foco se deu na intervenção e nos processos relacionais. Como considerações finais, apontou-se o quanto a experiência do sujeito ou o sujeito que constrói sua experiência precisa estar na pauta dos estudos que envolvem o tema da deficiência física. Esse tipo de olhar pode interferir no campo das políticas públicas, nos cuidados em saúde, na intervenção e, principalmente, no olhar lançado sobre e para o sujeito com algum tipo de deficiência física. Palavras-chave: Cultura. Pessoas com deficiência. Saúde da pessoa com deficiência. da Saúde.
Síndrome de Gorlin Goltz e suas implicações odontológicas
Authors: MARTINS Juliana Nascimento 
Published: October 2017

Este estudo tem por objetivo realizar uma revisão de literatura sobre a Síndrome de Gorlin Goltz com foco em sua principal complicação odontológica, o Tumor Odontogênico Ceratocístico. A busca foi feita nas bases de dados Pubmed, Science Direct e Wiley Online Library. Buscou-se artigos clínicos e pesquisas publicados no período de 2010 a 2015 que estivessem relacionados à Síndrome de Gorlin Goltz e ao Tumor Odontogênico Ceratocístico ou que abordassem a inter-relação entre ambos. Além disso, também foram selecionados estudos os quais abrangessem a importância do cirurgião dentista no diagnóstico precoce da morbidade de base a partir de achados do referido tumor. Somente as pesquisas em língua estrangeira, preferencialmente em inglês, foram incluídas nesta revisão. Diante das alterações fisiopatológicas que a Síndrome de Gorlin Goltz causa, compreende-se a relevância do acompanhamento desses pacientes por uma equipe multiprofissional, especialmente pelo cirurgião dentista, uma vez que este é o responsável direto pelo diagnóstico e tratamento da principal morbidade associada à síndrome. Palavras-chave: Carcinoma. Síndrome do nevo basocelular. Tumores odontogênicos.
Lactato sanguíneo, antes e após o teste de caminhada de seis minutos, em portadores de doença pulmonar obstrutiva crônica com diferentes graus de obstrução das vias aéreas
Authors: PASCHOAL Mário Augusto , SEIXAS Náira Bueno , GIANFRANCESCO Livea , CAMARGO Luisa Torres de 
Published: October 2017

ObjetivoAvaliar se pacientes com doença pulmonar obstrutiva crônica com maior obstrução das vias aéreas apresentam maiores elevações no valor de lactato sanguíneo durante o teste de caminhada de seis minutos.MétodosEstudo transversal aplicado em 29 indivíduos, divididos em três grupos: controle (n=10), doença pulmonar obstrutiva crônica leve (n=9) e doença pulmonar obstrutiva crônicamoderada (n=10). O grau da doença foi quantificado por meio dos valores do volume expiratório forçado do primeiro segundo e índice de Tiffeneau, obtidos em espirometria recente. Todos foram submetidos à avaliação antropométrica e clínica, além de ter a lactacidemia medida antes e após três minutos do teste de caminhada de seis minutos. Foi aplicado o teste de Kruskal-Wallis para comparação dos dados obtidos antes e após o teste de caminhada de seis minutos, e correlação de Spearman para avaliar a influência de variáveis sobre o lactato sanguíneo. O nível de significância foi p<0,05. ResultadosApesar de os pacientes com doença pulmonar obstrutiva crônica moderada terem apresentado o menor desempenho no teste de caminhada de seis minutos, representado pela menor distância percorrida (403,3m) em relação aos demais grupos (doença pulmonar obstrutiva crônica leve com 424,8m e controle com 541,8m), mostraram maiores valores médios de lactato no sangue (2,57mmol/L), quando comparados aos pacientes com doença pulmonar obstrutiva crônicaleve(1,46mmol/L) e ao grupo controle (0,9mmol/L). ConclusãoA maior obstrução das vias aéreas e sua repercussão sistêmica, resultaram na significativa limitação metabólica por parte dos pacientes com doença pulmonar obstrutiva crônica moderada, expressa pelos maiores valores de lactato sanguíneo e menor distância percorrida no teste de caminhada de seis minutos.
PERAN MUSIK DAN ASPEK KEPRIBADIAN TERHADAP KUALITAS HIDUP: STUDI KASUS TERHADAP TIGA PASIEN PASCA-STROKE DI JAKARTA
Authors: Luvita Irene , Hidajat Lidia L. 
Published: October 2017

Mendengarkan musik dapat menimbulkan perasaan positif seperti perasaan bahagia, memberikan motivasi, mengurangi rasa sakit, meningkatkan relaksasi, dan meningkatkan kualitas hidup pada pasien pasca-stroke dengan depresi, stres dan kecemasan. <strong> </strong>Aspek kepribadian juga memiliki peran ketika individu menghadapi kondisi stroke dan memengaruhi pemilihan musik yang didengarkan. <strong>Metode:</strong> <em>action research </em>dengan pendekatan kualitatif. Desain penelitian ini menggunakan studi kasus dan <em>one group pre-test pos-test</em>. Partisipan penelitian terdiri dari 3 orang dengan usia 40-75 tahun dan mengalami stroke pertama. Pengambilan data menggunakan wawancara, kuesioner DASS, SS-QOL, alat tes kepribadian TAT, dan <em>workbook </em>sebagai lembar kerja aktivitas intervensi. <strong>Hasil:</strong> ditemukan bahwa ketiga Partisipan mengalami penurunan kualitas hidup. Dua di antaranya mengalami depresi, stres, dan cemas karena kondisi stroke. Setelah dilakukan intervensi berupa mendengarkan musik setiap hari selama 2 minggu, didapatkan adanya peningkatan kualitas hidup pada beberapa dimensi. Musik yang mereka dengarkan sesuai dengan karakteristik kepribadian mereka. <strong>Kesimpulan:</strong> dampak stroke baik fisik, psikologis maupun sosial dapat menurunkan kualitas hidup seperti hubungan sosial, peran keluarga, emosi, perawatan diri, dan aspek lainnya. Mendengarkan musik setiap harinya sesuai dengan pilihan sendiri memberikan efek yang berbeda-beda bagi setiap orang dan ditemukan pula bahwa musik dapat meningkatkan kualitas hidup penderita pasca-stroke.
CONFORTO E FUNCIONALIDADE: MODIFICAÇÕES NA MODELAGEM E NOS AVIAMENTOS DE PEÇAS DE VESTUÁRIO INFANTIS MASCULINAS
Authors: Lima Bruna Lummertz , Costa Bárbara Farias 
Published: October 2017

Este estudo emergiu da pretensão de conceber peças de vestuário para meninos de 1 a 5 anos, as quais fossem práticas para vestir e contribuíssem para a sua independência. O trabalho foi desenvolvido no decorrer do processo de concepção e desenvolvimento de uma coleção de moda infantil, direcionada ao vestuário masculino no ano de 2014. Iniciou com o mapeamento de necessidades de conforto e funcionalidade no vestuário infantil masculino, a partir da observação de meninos em uma escola de educação infantil na cidade de Imbé/RS. Após a realização do experimento, ocorreu o processo de desenvolvimento, no qual as autoras buscaram alterar a configuração de peças de vestuário, por meio de mudanças na modelagem e optando por aviamentos funcionais. Por fim, comprovou-se que as mudanças sutis nas peças proporcionaram praticidade e conforto aos usuários, e que as alterações mencionadas eram de fácil incorporação a projetos de moda com objetivos semelhantes. Palavras-chave: Conforto. Funcionalidade. Modelagem. Vestuário infantil.
A EDUCAÇÃO NO MUNDO DO TRABALHO: UMA REFLEXÃO SOBRE AS POTENCIALIDADES E LIMITES DA PEDAGOGIA TRANSDISCIPLINAR EM UNIVERSIDADES CORPORATIVAS
Authors: Vianna Patrícia De Sousa 
Published: October 2017

Um fenômeno que vem crescendo nas principais economias do mundo, incluindo o Brasil, é a criação de Universidades Corporativas (UCs) pelas grandes organizações como forma de lidar com a assimetria entre as competências profissionais desejadas e as encontradas no mercado de trabalho. Contemporaneamente, a gestão do conhecimento, as organizações de aprendizagem e o capital intelectual permeiam as reflexões não só acadêmicas, mas da sociedade em geral, as quais repercutem no âmbito das corporações e de suas UCs. Essa temática desdobra-se em reflexões sobre quais abordagens pedagógicas são adequadas às demandas da vida contemporânea, e a visão transdisciplinar se apresenta como uma das respostas possíveis. Observa-se que a UC assume um papel cada vez mais estratégico, extrapolando a função formativa de competências funcionais e alcançando um escopo diversificado de gestão: do conhecimento, da identidade e da cultura organizacionais. Este ensaio aborda o papel desempenhado pela UC na estratégia organizacional, notadamente nas políticas de gestão de pessoas. Tais reflexões partem da atuação da autora como educadora de uma UC ao longo de dez anos, tendo como pano de fundo as teorias de Edgar Morin e Basarab Nicolescu.Palavras-chave: Transdisciplinaridade. Educação. Gestão de pessoas.