bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring of novel reverse thermally induced phase separation process based on preparation and characterization of polysulfate ultrafiltration membranes with bicontinuous structure
Authors: Wang Wei , Sun Linghao , Wang Jiaqi , Zeng Fanfu , Xu Baiyu 
Published: September 2024

AbstractContaminated water sources from various industries pose severe environmental challenges due to their complex compositions, high toxicity, and fluctuating qualities. This study introduces a groundbreaking strategy for fabricating advanced polysulfate (PSE) ultrafiltration membranes using a novel reverse thermally induced phase separation (RTIPS) process. By manipulating the cloud point through the DMAc/DEG solvent/nonsolvent system, our work innovatively controls membrane microstructure, overcoming limitations of conventional nonsolvent‐induced phase separation (NIPS). Our findings reveal that RTIPS, when employed above the cloud point, yields PSE membranes with a unique bicontinuous sponge‐like structure, significantly improving upon conventional NIPS products. Specifically, the optimized RTIPS membranes exhibit enhanced pure water flux (916.23 vs. 336.23 LMH), larger pore sizes (0.083 vs. 0.054 μm), increased tensile strength (1.32 vs. 0.84 MPa), and improved fouling resistance (FRR 65.5% vs. 55.2%). This research pioneers a facile yet potent method for tailoring membrane properties, achieving a balance between permeability, mechanical stability, and filtration efficacy. The demonstrated success of RTIPS in enhancing PSE membrane performance not only contributes to the development of high‐performance water treatment technologies but also charts a new course in membrane science, offering a promising avenue for sustainable wastewater management solutions.
Assessment of Octocoral‐Dominated Benthic Assemblages Along a Mesophotic Gradient, With a Focus on the Impact of Lost Fishing Gears
Authors: Jacobsen Nils Lucas , Roveta Camilla , Pulido Mantas Torcuato , Coppari Martina , Di Camillo Cristina Gioia , Calcinai Barbara , Cerrano Carlo 
Published: September 2024

ABSTRACTCoralligenous, a typical Mediterranean mesophotic habitat, is a highly diverse assemblage, severely threatened by several stressors, including fishing litter. To characterise the coralligenous of the upper mesophotic of the Portofino Promontory (Ligurian Sea, Italy), video transects at 35 and 50 m depth were performed at four sites. Benthic assemblages and lost fishing gears were recorded, and the two depths compared. A higher coverage of taxa with complex 3D structures was found at 50 m, mainly due to the gorgonian Paramuricea clavata. However, the overall low density of this species (0.4–6.6 colonies/m2), together with the impact caused by 120 fishing lines found along the transects, highlights the need for tailored conservation measures. With climate change moving further down the water column and fishing impacts being a major cause of degradation, the design of marine protected areas needs to be extended to include mesophotic depths, contributing to the 30 × 30 targets agreed upon at the COP15.
BODIPY‐Helicene Based Heavy‐Atom‐Free Photocatalyst for Oxidative Coupling of Amines and Photooxidation of Sulfides
Authors: Koli Mrunesh , Gamre Sunita , Ghosh Rajib , Wadawale A. P. , Ghosh Ayan , Ghanty Tapan K. , Mula Soumyaditya 
Published: September 2024

AbstractTo develop heavy‐atom‐free triplet photosensitizers (PSs) based photocatalysts, we designed and synthesized two BODIPY‐helicene dyes by fusing the BODIPY core and modified [5]helicene structures. These BODIPY‐helicenes structures are twisted and their twisting angles are increased by the developed synthetic method. The BODIPY‐helicenes have broad absorption bands over UV‐visible region with high triplet conversions and long triplet lifetimes as compared to planar BODIPY dye, PM567. Consequently, these dyes are also highly efficient in generating 1O2 by transferring their triplet energy to 3O2. All these are confirmed by dye‐sensitised photooxidation reaction, nanosecond transient absorption spectroscopy study, phosphorescence measurement and DFT calculations. Finally, photocatalytic activity of the highest 1O2 generating BODIPY‐helicene (4 b) was checked. 4 b is highly efficient in photocatalytic oxidative coupling of differently substituted amines through aerobatic oxidation using 1O2 generated by its photosensitization. It is also highly efficient photocatalyst for aerobatic oxidation of sulfides to sulfoxides. Importantly, the photocatalyst could be quantitatively recovered and reused for several cycles. All these results confirmed the potential use of the BODIPY‐helicenes as PSs for photocatalytic organic reactions and the design strategy will be useful for the future development of heavy‐atom‐free photocatalyst.
Faba bean nutrition: Macronutrients, antinutrients, and the effect of processing
Authors: Shi Dai , Stone Andrea K. , Marinangeli Christopher P. F. , Carlin Janelle , Nickerson Michael T. 
Published: September 2024

AbstractBackground and ObjectivesFaba beans are emerging as highly nutritious ingredients that have the potential to contribute to the global demand for healthy and sustainable plant‐based proteins. The current review aims to provide a summarized overview of faba bean macronutrients, protein quality, and antinutritional factors (ANFs), as well as their reduction strategies through a variety of processing means.FindingsRelative to other pulses, faba beans are higher in protein content and similar in protein quality. However, without proper preparation and/or processing, the presence of minor amounts of ANFs can hinder their nutritional value. These nonnutritive, but biologically active, compounds can be diminished through mechanical, thermal, and nonthermal treatments.ConclusionsNonconventional processing techniques to retain or improve protein quality remain an area of future research for improving faba bean nutrition and expanding its utilization.Significance and NoveltyThis review will advance the science and utilization of faba bean ingredients while providing future research opportunities.
A rare case of primary signet‐ring adenocarcinoma of anorectal region in a young patient: Diagnostic challenges and therapeutic outcomes
Authors: Shaikh Bisma , Gul Areeba , Singh Ajeet , Irfan Hamza , Ali Tooba , Karamat Riyan , Akilimali Aymar 
Published: September 2024

Key Clinical MessagePrimary signet‐ring cell carcinoma of the anal canal and rectum is an extremely rare and aggressive malignancy. The present case underscores the importance of considering primary signet‐ring cell carcinoma in differential diagnoses for young patients with chronic anorectal symptoms. It highlights the need for a multidisciplinary treatment approach (including surgery, chemotherapy, and radiotherapy) and comprehensive follow‐up for managing this challenging condition and improving long‐term patient outcomes.AbstractPrimary signet‐ring cell carcinoma of the anal canal and rectum is an exceedingly rare subtype of colorectal adenocarcinoma, often originating as an extension of rectal adenocarcinoma. This malignancy constitutes a small fraction of colorectal cancers and is scarcely reported in medical literature. We present the case of an 18‐year‐old male with a three‐year history of progressively worsening hematochezia, anorectal pain, and defecation‐associated prolapse. Initial conservative treatments failed, leading to further investigations that revealed a palpable, nodular anorectal mass. Imaging studies (including CT and MRI), and biopsy confirmed poorly differentiated adenocarcinoma with signet‐ring cell morphology. The tumor exhibited extensive lymphovascular invasion and involved perirectal lymph nodes, and was staged as pT3, N2a. Immunohistochemical staining was positive for CK 7, CK 20, and SATB2, supporting the primary anorectal origin. The treatment regimen included initial diversion colostomies for symptom relief, followed by neoadjuvant chemotherapy with a modified 5‐fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) regimen and concurrent chemoradiation with Xeloda. The patient subsequently underwent an abdominoperineal resection (APR), which confirmed the diagnosis and achieved curative resection. Postoperative complications included transient ileus and wound infection, which were managed with supportive care. This case underscores the diagnostic and therapeutic challenges posed by primary signet‐ring cell carcinoma of the anorectal region, highlighting the need for a high index of suspicion and comprehensive diagnostic workup in atypical presentations. The multimodal treatment approach, incorporating surgery, chemotherapy, and radiotherapy, was crucial in managing this locally advanced tumor. The rarity and aggressiveness of this carcinoma necessitate a tailored treatment strategy to improve patient outcomes. Long‐term follow‐up, including regular imaging and surveillance, is vital for monitoring disease recurrence and evaluating treatment effectiveness.
Cyclodextrin Dimers Functionalized with Biotin as Nanocapsules for Active Doxorubicin Delivery Against MCF‐7 Breast Cell Line
Authors: Bognanni Noemi , Scuderi Chiara , Giglio Valentina , Spiteri Fabio , La Piana Luana , Condorelli Daniele , Barresi Vincenza , Vecchio Graziella 
Published: September 2024

AbstractCyclodextrin dimers have been investigated as potential nanocapsules of biomolecules. The presence of two cavities can improve the stability of inclusion complexes, working as a hydrophilic sandwich of poorly water‐soluble species. Here, we designed new β‐ and γ‐cyclodextrin dimers functionalized with biotin as a targeting unit and tested the new bioconjugates as doxorubicin delivery systems in cancer cells. Biotin can recognize the Sodium‐dependent Multivitamin Transporter (SMVT) receptor, encoded by the Solute Carrier Family 5 Member 6 (SLC5A6) gene and improve the uptake of drugs. We evaluated the expression of the SLC5A6 transcript in human cell lines to select the best cell model (MCF‐7) for the in vitro studies.Furthermore, in the cell lines, we investigated the transcript levels of genes correlated to biotin cell availability, Holocarboxylase Synthetase (or HCS encoded by HLCS gene) and Biotinidase (encoded by BTD gene) enzymes. Moreover, the expression of ATP Binding Cassette Subfamily G Member 2 transporter (encoded by ABCG2 gene), which may play a role in doxorubicin resistance, has been investigated. The antiproliferative activity of the doxorubicin complexes with the dimers has been determined to study the effect of the biotin moiety on the cytotoxicity in MCF‐7 cancer cells.
Unveiling the functional roles of patient‐derived tumour organoids in assessing the tumour microenvironment and immunotherapy
Authors: Chen Di , Xu Lixia , Xuan Mengjuan , Chu Qingfei , Xue Chen 
Published: September 2024

AbstractRecent studies have established the pivotal roles of patient‐derived tumour organoids (PDTOs), innovative three‐dimensional (3D) culture systems, in various biological and medical applications. PDTOs, as promising tools, have been established and extensively used for drug screening, prediction of immune response and assessment of immunotherapeutic effectiveness in various cancer types, including glioma, ovarian cancer and so on. The overarching goal is to facilitate the translation of new therapeutic modalities to guide personalised immunotherapy. Notably, there has been a recent surge of interest in the co‐culture of PDTOs with immune cells to investigate the dynamic interactions between tumour cells and immune microenvironment. A comprehensive and in‐depth investigation is necessary to enhance our understanding of PDTOs as promising testing platforms for cancer immunotherapy. This review mainly focuses on the latest updates on the applications and challenges of PDTO‐based methods in anti‐cancer immune responses. We strive to provide a comprehensive understanding of the potential and prospects of PDTO‐based technologies as next‐generation strategies for advancing immunotherapy approaches.
Enhanced channel estimation with atomic norm minimization and reconfigurable intelligent surfaces in mmWave MIMO systems
Authors: Ganapathy Sundar , Muthusamy Karthikeyan 
Published: September 2024

SummaryThe performance of millimeter‐wave (mmWave) multiple‐input multiple‐output (MIMO) systems has been significantly enhanced by the incorporation of dynamic reconfigurable intelligent surfaces (RIS). This paper proposes a novel dynamic channel estimation technique that combines dynamic atomic norm minimization with dynamic RIS to optimize RIS‐aided mmWave MIMO systems. Leveraging the dynamic nature of both atomic norm minimization and RIS, the proposed approach efficiently adapts to changing environmental conditions, providing robust and accurate channel estimation. By dynamically optimizing the RIS configuration, the system achieves improved spectral and energy efficiency, enabling high‐speed and reliable communication in challenging mmWave environments. Theoretical analysis and simulation results demonstrate the effectiveness of the proposed dynamic channel estimation technique, highlighting its potential for enhancing the performance of future wireless communication systems.
Landscape structure and site characteristics influence whether the northern house martin Delichon urbicum occupies artificial nests
Authors: Allera Gianna , Heim Ramona Julia , Förster Aline , Heim Wieland 
Published: September 2024

AbstractArtificial nest sites can support populations of endangered species when they are correctly installed. Here we analysed the characteristics and conditions that determined whether the northern house martin Delichon urbicum occupied more than 300 artificial nests around the city of Münster, Germany. We found that artificial nest occupation rates were influenced by various environmental and temporal factors. Positive influences included a longer time since installation and, to a lesser extent, the number of artificial nests at the same site. Negative impacts were observed from higher proportions of sealed surface cover in the surrounding area and, to a lesser extent, southward exposure. The distance to the nearest water body and the number of occupied natural nests showed no significant effect. We compared our results with descriptive evidence from the grey literature and published reports, and we give recommendations for installing artificial house martin nests for conservation practitioners. Future studies should also investigate the potential negative effects of ‘dirt boards’ below the nests and of gaps between the roof and the artificial nests.
Phylogenetic relatedness of plant species co‐occurring with an invasive alien plant species varies with elevation
Authors: Afshana  , Pinto‐Ledezma Jesús N. , Reshi Zafar A. 
Published: September 2024

AbstractDarwin's naturalization conundrum posits that the alien species either succeed in the introduced region because they are phylogenetically related to the native species and thus tend to have niches similar to those of native species, or they are phylogenetically dissimilar to native species and thus occupy unfilled niches. This conundrum has received a lot of attention, but the findings regarding these two hypotheses have been contradictory. To reconcile the two seemingly contradictory hypotheses, we assessed the phylogenetic relationship of a highly widespread and invasive species, Anthemis cotula L. (focal species), separately with the native species and all its co‐occurring species (including native and non‐native species) along an elevation gradient. Our results show that the abundance of A. cotula declined continuously with an increase in elevation and with an increase in the number of both all co‐occurring and native species only. The phylogenetic distance between the focal species and the native species based on weighted mean pairwise distance (MPDaw) declined with elevation as well as native species richness. Our study also revealed that soil nutrients strongly influence the abundance of A. cotula; however, their effect on the phylogenetic distance between the focal and other species is negligible. These findings suggest a strong role of microecological factors and spatial heterogeneity in the abundance distributions of invasive species and community assembly. Thus, it could be concluded that the phylogenetic relationship of A. cotula with co‐occurring all or only native species varies with elevation and species richness, adding another layer of complexity to the resolution of Darwin's naturalization conundrum.
Wild bird mass mortalities in eastern Canada associated with the Highly Pathogenic Avian Influenza A(H5N1) virus, 2022
Authors: Avery‐Gomm Stephanie , Barychka Tatsiana , English Matthew , Ronconi Robert A. , Wilhelm Sabina I. , Rail Jean‐François , Cormier Tabatha , Beaumont Matthieu , Bowser Campbell , Burt Tori V. , Collins Sydney M. , Duffy Steven , Giacinti Jolene A. , Gilliland Scott , Giroux Jean‐François , Gjerdrum Carina , Guillemette Magella , Hargan Kathryn E. , Jones Megan , Kennedy Andrew , Kusalik Liam , Lair Stéphane , Lang Andrew , Lavoie Raphael A. , Lepage Christine , McPhail Gretchen , Montevecchi William A. , Parsons Glen J. , Provencher Jennifer F. , Rahman Ishraq , Robertson Gregory J. , Seyer Yannick , Soos Catherine , Ward Christopher R. E. , Wells Regina , Wight Jordan 
Published: September 2024

AbstractIn 2022, a severe outbreak of disease caused by clade 2.3.4.4b Highly Pathogenic Avian Influenza (HPAI) H5N1 virus resulted in unprecedented mortality among wild birds in eastern Canada. Tens of thousands of birds were reported sick or dead, prompting a comprehensive assessment of mortality spanning the breeding season between April 1 and September 30, 2022. Mortality reports were collated from federal, Indigenous, provincial, and municipal agencies, the Canadian Wildlife Health Cooperative, and other nongovernmental organizations, universities, and citizen science platforms. A scenario analysis was conducted to refine mortality estimates, accounting for potential double counts from multiple sources under a range of spatial and temporal overlaps. Correcting for double counting, HPAI is estimated to have caused 40,391 wild bird mortalities in eastern Canada during the spring and summer of 2022; however, this figure underestimates total mortality as it excludes unreported deaths on land and at sea. Seabirds and sea ducks, long‐lived species that are slow to recover from perturbations, accounted for 98.7% of estimated mortalities. Our study provides estimates of bird mortality, with Northern Gannets (Morus bassanus; 25,669), Common Murres (Uria aalge; 8133), and American Common Eiders (Somateria mollissima dresseri; 1894) exhibiting the highest mortality figures. We then compare these mortality estimates with recent population estimates and trends and make an initial assessment of whether biologically meaningful population‐level impacts are possible. Specifically, we focus on the Northern Gannet, a species that has suffered significant global mortality, and two harvested species, Common Murre and American Common Eider, to inform management decisions. Our analysis suggests population‐level impacts in eastern Canada are possible for Northern Gannets and American Common Eiders, but are unlikely for Common Murres. This study demonstrates a comprehensive approach to assessing mortality and underscores the urgent need for further research to understand the broader ecological ramifications of the HPAI outbreak on wild bird populations.
Changes in inflammatory edema and fat fraction of thigh muscles following a half‐marathon in recreational marathon runners
Authors: Shu Dingbo , Wang Jianping , Meng Fanjing , Dai Siyu , Zhao Zhenhua 
Published: September 2024

AbstractIt is known that microtrauma exists in the thigh muscles after long‐distance running such as the half‐marathon. Moreover, training characteristics of long‐distance runners may influence the specificity of the distribution of muscle fiber types in the thigh and affect muscle responses to lipid metabolism. However, the specific changes in microtrauma and intramuscular lipid in thigh muscles after a half‐marathon are unknown. A cohort of 20 healthy recreational marathon runners was recruited to complete a half‐marathon. MRI T2 mapping and 6‐echo q‐Dixon sequences were employed at baseline (P1), 2–3 h after running (P2), and 1 day after running (P3). Inflammatory markers (the T2 values) and intramuscular fat fraction (the proton density fat fraction, PDFF) were measured in thigh muscles to detect microtrauma and intramuscular lipid changes, respectively. One‐way analysis of variance showed significant time effects for T2 values and PDFF. Post hoc analysis of the 14 datasets collected at three time points revealed significantly higher T2 values in all thigh muscles after running (all p < 0.05). Significant differences in T2 values persisted for all thigh muscles at P3 compared to P1 (all p < 0.05). The PDFF of the vastus lateralis and vastus medialis was significantly decreased at P2 compared to P1 (p < 0.05). No significant differences in PDFF were observed for the thigh muscles at P3 compared to P1. The manifestations of inflammation edema and intramuscular lipid investigated through MRI may offer valuable insights for recreational marathon runners regarding the lower limb movement characteristics during half‐marathon running.
High‐order multilayer attention fusion network for 3D object detection
Authors: Zhang Baowen , Zhao Yongyong , Su Chengzhi , Cao Guohua 
Published: September 2024

AbstractThree‐dimensional object detection based on the fusion of 2D image data and 3D point clouds has become a research hotspot in the field of 3D scene understanding. However, different sensor data have discrepancies in spatial position, scale, and alignment, which severely impact detection performance. Inappropriate fusion methods can lead to the loss and interference of valuable information. Therefore, we propose the High‐Order Multi‐Level Attention Fusion Network (HMAF‐Net), which takes camera images and voxelized point clouds as inputs for 3D object detection. To enhance the expressive power between different modality features, we introduce a high‐order feature fusion module that performs multi‐level convolution operations on the element‐wise summed features. By incorporating filtering and non‐linear activation, we extract deep semantic information from the fused multi‐modal features. To maximize the effectiveness of the fused salient feature information, we introduce an attention mechanism that dynamically evaluates the importance of pooled features at each level, enabling adaptive weighted fusion of significant and secondary features. To validate the effectiveness of HMAF‐Net, we conduct experiments on the KITTI dataset. In the “Car,” “Pedestrian,” and “Cyclist” categories, HMAF‐Net achieves mAP performances of 81.78%, 60.09%, and 63.91%, respectively, demonstrating more stable performance compared to other multi‐modal methods. Furthermore, we further evaluate the framework's effectiveness and generalization capability through the KITTI benchmark test, and compare its performance with other published detection methods on the 3D detection benchmark and BEV detection benchmark for the “Car” category, showing excellent results. The code and model will be made available on
https://github.com/baowenzhang/High‐order‐Multilayer‐Attention‐Fusion‐Network‐for‐3D‐Object‐Detection.