bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early mortality and complications in hospitalized adult Californians with acute myeloid leukaemia
Authors: Ho Gwendolyn , Jonas Brian A. , Li Qian , Brunson Ann , Wun Ted , Keegan Theresa H. M. 
Published: April 2017

SummaryFew studies have evaluated the impact of complications, sociodemographic and clinical factors on early mortality (death ≤60 days from diagnosis) in acute myeloid leukaemia (AML) patients. Using data from the California Cancer Registry linked to hospital discharge records from 1999 to 2012, we identified patients aged ≥15 years with AML who received inpatient treatment (N = 6359). Multivariate logistic regression analyses were used to assess the association of complications with early mortality, adjusting for sociodemographic factors, comorbidities and hospital type. Early mortality decreased over time (25·3%, 1999–2000; 16·8%, 2011–2012) across all age groups, but was higher in older patients (6·9%, 15–39, 11·4%, 40–54, 18·6% 55–65, and 35·8%, >65 years). Major bleeding [Odds ratio (OR) 1·5, 95% confidence interval (CI) 1·3–1·9], liver failure (OR 1·9, 95% CI 1·1–3·1), renal failure (OR 2·4, 95% CI 2·0–2·9), respiratory failure (OR 7·6, 95% CI 6·2–9·3) and cardiac arrest (OR 15·8, 95% CI 8·7–28·6) were associated with early mortality. Higher early mortality was also associated with single marital status, low neighbourhood socioeconomic status, lack of health insurance and comorbidities. Treatment at National Cancer Institute‐designated cancer centres was associated with lower early mortality (OR 0·5, 95% CI 0·4–0·6). In conclusion, organ dysfunction, hospital type and sociodemographic factors impact early mortality. Further studies should investigate how differences in healthcare delivery affect early mortality.
Cortactin, a Lyn substrate, is a checkpoint molecule at the intersection of BCR and CXCR4 signalling pathway in chronic lymphocytic leukaemia cells
Authors: Martini Veronica , Gattazzo Cristina , Frezzato Federica , Trimarco Valentina , Pizzi Marco , Chiodin Giorgia , Severin Filippo , Scomazzon Edoardo , Guzzardo Vincenza , Saraggi Deborah , Raggi Flavia , Martinello Leonardo , Facco Monica , Visentin Andrea , Piazza Francesco , Brunati Anna Maria , Semenzato Gianpietro , Trentin Livio 
Published: April 2017

SummaryCortactin (CTTN) is a substrate of the Src kinase Lyn that is known to play an actin cytoskeletal regulatory role involved in cell migration and cancer progression following its phosphorylation at Y421. We recently demonstrated that Cortactin is overexpressed in patients with chronic lymphocytic leukaemia (CLL). This work was aimed at defining the functional role of Cortactin in these patients. We found that Cortactin is variably expressed in CLL patients both in the peripheral blood and lymph nodes and that its expression correlates with the release of matrix metalloproteinase 9 (MMP‐9) and the motility of neoplastic cells. Cortactin knockdown, by siRNA, induced a reduction in MMP‐9 release as well as a decrease of migration capability of leukaemic B cells in vitro, also after chemotactic stimulus. Furthermore, Cortactin phosphorylation was lowered by the Src kinase‐inhibitor PP2 with a consequent decrease of MMP‐9 release in culture medium. An impaired migration, as compared to control experiments without Cortactin knockdown, was observed following CXCL12 triggering. Reduced Cortactin expression and phosphorylation were also detected both in vivo and in vitro after treatment with Ibrutinib, a Btk inhibitor. Our results highlight the role of Cortactin in CLL as a check‐point molecule between the BCR and CXCR4 signalling pathways.
Detailed immunophenotyping of B‐cell precursors in regenerating bone marrow of acute lymphoblastic leukaemia patients: implications for minimal residual disease detection
Authors: Theunissen Prisca M. J. , Sedek Lukasz , De Haas Valerie , Szczepanski Tomasz , Van Der Sluijs Alita , Mejstrikova Ester , Nováková Michaela , Kalina Tomas , Lecrevisse Quentin , Orfao Alberto , Lankester Arjan C. , van Dongen Jacques J. M. , Van Der Velden Vincent H. J. ,   the EuroFlow Consortium
Published: April 2017

SummaryFlow cytometric detection of minimal residual disease (MRD) in children with B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) requires immunophenotypic discrimination between residual leukaemic cells and B‐cell precursors (BCPs) which regenerate during therapy intervals. In this study, EuroFlow‐based 8‐colour flow cytometry and innovative analysis tools were used to first characterize the immunophenotypic maturation of normal BCPs in bone marrow (BM) from healthy children, resulting in a continuous multiparametric pathway including transition stages. This pathway was subsequently used as a reference to characterize the immunophenotypic maturation of regenerating BCPs in BM from children treated for BCP‐ALL. We identified pre‐B‐I cells that expressed low or dim CD34 levels, in contrast to the classical CD34high pre‐B‐I cell immunophenotype. These CD34−dim pre‐B‐I cells were relatively abundant in regenerating BM (11–85% within pre‐B‐I subset), while hardly present in healthy control BM (9–13% within pre‐B‐I subset; P = 0·0037). Furthermore, we showed that some of the BCP‐ALL diagnosis immunophenotypes (23%) overlapped with CD34−dim pre‐B‐I cells. Our results indicate that newly identified CD34−dim pre‐B‐I cells can be mistaken for residual BCP‐ALL cells, potentially resulting in false‐positive MRD outcomes. Therefore, regenerating BM, in which CD34−dim pre‐B‐I cells are relatively abundant, should be used as reference frame in flow cytometric MRD measurements.
Young people's beliefs about the risk of bowel cancer and its link with physical activity
Authors: Newby Katie V. , Cook Chloe , Meisel Susanne F. , Webb Thomas L. , Fisher Bernadette , Fisher Abi 
Published: April 2017

ObjectivesThe primary objective was to explore young people's risk appraisals of bowel cancer, including whether they had a coherent understanding of the protective effects of physical activity (PA). A secondary objective was to examine whether the illness risk representations (IRRs) framework could be used to understand beliefs underlying bowel cancer risk appraisals.DesignQualitative.MethodsFramework analysis of semi‐structured interviews with 19 people aged 14–17 years.ResultsParticipants judged their risk of getting bowel cancer as low. This was based on a lack of family history of cancer and their current lifestyle behaviours, which were viewed as having a protective effect, or because they planned on making change to their lifestyle in the future when disease risk became more relevant. Participants were not aware of, and struggled to understand, the link between PA and bowel cancer. They also lacked knowledge of the effects of, or treatments for, bowel cancer. Beliefs underlying judgements about the risk of bowel cancer fitted the IRR framework reasonably well.ConclusionsThe present research suggests that interventions designed to increase PA with a view to reducing the risk of bowel cancer should aim to make the future risk of bowel cancer feel more tangible, help young people to understand the full range of consequences, explain how and why preventative behaviours such as PA are effective in reducing risk, and emphasize that the typical late presentation of symptoms, and therefore investigation by health care services, reduces treatability.
Statement of contribution

What is already known on this subject?

Physical activity (PA) performed throughout the lifespan can have a protective effect on bowel cancer, but levels of PA are low among young people.

Changing beliefs about the risk of getting bowel cancer may be a useful strategy in motivating PA.

What does this study add?

Increased understanding of how young people think about bowel cancer and the relationship between PA and cancer.

Identification of strategies for increasing young adults’ appraisals of the likelihood and severity of bowel cancer.

Evidence to support the validity of illness risk representations framework.
Fluvial architecture in actively deforming salt basins: Chinle Formation, Paradox Basin, Utah
Authors: Hartley Adrian , Evenstar Laura 
Published: April 2017

AbstractDetermining the response of fluvial systems to syn‐sedimentary halokinesis is important for reconstructing the palaeogeography of salt basins, determining the history of salt movement and predicting development and architecture of sandstone bodies for subsurface fluid extraction. To assess both the influence of salt movement on fluvial system development and the use of lithostratigraphic correlation schemes in salt basins we have analysed the Triassic Chinle Formation in the Paradox Basin, Utah. Results indicate that sandstone body development proximal to salt bodies should be considered at two scales: intra‐ (local) and inter‐ (regional) mini‐basin scale. At the intra‐mini basin or local scale, conformable packages of up to 12 m deep meandering fluvial channel deposits and associated overbank deposits are developed, which may thin, pinch‐out or become truncated towards salt highs. When traced down the axis of a mini‐basin, individual stories extend for a few hundred metres, and form part of amalgamated channel‐belt packages up to 60 m thick that can be traced for at least 25 km parallel to palaeoflow. Where salt movement outpaces sediment accumulation, progressive low angle unconformities are developed along the flanks of salt highs. Significantly, in mini‐basins with high sand supply, sandstone bodies are present across salt highs where they show increased amalgamation, decrease in thickness due to truncation and no change in internal sandstone body character. At inter mini‐basin or regional scale, spatial and temporal variations in accommodation space generated by differential salt movement strongly influence facies distributions and facies correlation lengths. Broad lithostratigraphic packages (5–50 m thick) can be correlated within mini‐basins, but correlation of these units between adjacent mini‐basins is problematic. Knowledge of fluvial system development at a regional scale is critical as, fluvial sediment distribution is focussed by topography generated by growing salt bodies, such that adjacent mini‐basins can have significant differences in sandstone body thickness, distribution and lateral extent. The observations from the Chinle Formation indicate that lithostratigraphic‐based correlation schemes can only be applied within mini‐basins and cannot be used to correlate between adjacent mini‐basins or across a salt mini‐basin province. The key to predicting sandstone body development is an understanding of the timing of salt movement and reconstructing fluvial drainage system development.
Prolonged breastfeeding for 24 months or more and mental health at 6 years of age: evidence from the 2004 Pelotas Birth Cohort Study, Brazil
Authors: Delgado Carlos Alberto , Munhoz Tiago N. , Santos Iná S. , Barros Fernando C. , Matijasevich Alicia 
Published: April 2017

BackgroundThere is scarce and conflicting evidence on medium‐ to long‐term effects of prolonged breastfeeding on child behavior.MethodA population‐based birth cohort study started in 2004 in the city of Pelotas, Southern Brazil. Children were followed up at 3, 12, 24, and 48 months and 6 years of age. Breastfeeding duration was determined based on information collected around the time of weaning. Psychiatric disorders were assessed using the Development and Well‐Being Assessment (DAWBA). Children who were never breastfed were excluded from the analysis. Crude and adjusted analyses were performed using Poisson regression with robust variance.ResultsData on breastfeeding and mental health at the age of 6 years were available for 3377 children. Prevalence of breastfeeding for 24–35 months and ≥36 months was 16.1% (95% CI: 14.8–17.3) and 8.1% (95% CI: 7.2–9.1), respectively. Prevalence of psychiatric disorders among those who were breastfed for <24 months, 24–35 months and ≥36 months was 12.4% (95% CI: 11.1–13.7), 13.1% (95% CI: 10.4–16.2) and 12.3% (95% CI: 8.7–16.8), respectively. No association was found between breastfeeding for 24 months or more and psychiatric disorders among children aged 6 years both in the crude and adjusted analyses.ConclusionsIn this cohort there was no association between breastfeeding for 24 months or more and an increased prevalence of psychiatric disorders at the age of 6 years. Studies analyzing the medium‐ and long‐term effects of prolonged breastfeeding for 2 years or more are scarce and further research is needed regarding this practice.
Stakeholders' views of the introduction of assistive technology in the classroom: How family‐centred is Australian practice for students with cerebral palsy?
Authors: Karlsson P. , Johnston C. , Barker K. 
Published: April 2017

AbstractBackgroundWith family‐centred care widely recognized as a cornerstone for effective assistive technology service provision, the current study was undertaken to investigate to what extent such approaches were used by schools when assistive technology assessments and implementation occurred in the classroom.MethodIn this cross‐sectional study, we compare survey results from parents (n = 76), school staff (n = 33) and allied health professionals (n = 65) with experience in the use of high‐tech assistive technology. Demographic characteristics and the stakeholders' perceived helpfulness and frequency attending assessment and set‐up sessions were captured. To evaluate how family‐centred the assistive technology services were perceived to be, the parents filled out the Measure of Processes of Care for Caregivers, and the professionals completed the Measure of Processes of Care for Service Providers. Descriptive statistics and one‐way analysis of variance were used to conduct the data analysis.ResultsFindings show that parents are more involved during the assessment stage than during the implementation and that classroom teachers are often not involved in the initial stage. Speech pathologists in particular are seen to be to a great extent helpful when implementing assistive technology in the classroom. This study found that family‐centred service is not yet fully achieved in schools despite being endorsed in early intervention and disability services for over 20 years. No statistically significant differences were found with respect to school staff and allied health professionals' roles, their years of experience working with students with cerebral palsy and the scales in the Measure of Processes of Care for Service Providers.ConclusionTo enhance the way technology is matched to the student and successfully implemented, classroom teachers need to be fully involved in the whole assistive technology process. The findings also point to the significance of parents' involvement, with the support of allied health professionals, in the process of selecting and implementing assistive technology in the classroom.
The Role of Family Characteristics for Students’ Academic Outcomes: A Person‐Centered Approach
Authors: Häfner Isabelle , Flunger Barbara , Dicke Anna‐Lena , Gaspard Hanna , Brisson Brigitte M. , Nagengast Benjamin , Trautwein Ulrich 
Published: April 2017

Using data from 1,571 ninth‐grade students (Mage = 14.62) from 82 academic track schools in Germany and their predominantly Caucasian middle‐class parents, configurations of different family characteristics reported by parents were investigated. Latent profile analyses considering academic involvement, family interest, parents’ self‐concept, child's need for support, and parents’ time and energy identified average, indifferent, motivated and engaged, motivated and disengaged, and involved families. Cross‐sectional and longitudinal associations with students’ motivational (self‐concept, effort, and interest) and achievement outcomes (achievement test and grades) in math were analyzed. Students from families classified as motivated and disengaged showed higher initial levels motivation and achievement. Over 5 months, these students also showed an increase in self‐concept and higher achievement than students from other family types.
Understanding the Transfer Deficit: Contextual Mismatch, Proactive Interference, and Working Memory Affect Toddlers’ Video‐Based Transfer
Authors: Choi Koeun , Kirkorian Heather L. , Pempek Tiffany A. 
Published: April 2017

Researchers tested the impact of contextual mismatch, proactive interference, and working memory (WM) on toddlers’ transfer across contexts. Forty‐two toddlers (27–34 months) completed four object‐retrieval trials, requiring memory updating on Trials 2–4. Participants watched hiding events on a tablet computer. Search performance was tested using another tablet (match) or a felt board (mismatch). WM was assessed. On earlier search trials, WM predicted transfer in both conditions, and toddlers in the match condition outperformed those in the mismatch condition; however, the benefit of contextual match and WM decreased over trials. Contextual match apparently increased proactive interference on later trials. Findings are interpreted within existing accounts of the transfer deficit, and a combined account is proposed.
From Autonomy to Divinity: The Cultural Socialization of Moral Reasoning in an Evangelical Christian Community
Authors: DiBianca Fasoli Allison 
Published: April 2017

This study examined moral reasoning in parent–child conversations within a U.S. evangelical Christian community. The goal was to identify social‐communicative processes that may promote the development of Divinity in children's moral reasoning. Sixteen parent–child dyads (6–9 years old) discussed hypothetical moral vignettes about failures to help peers in need. Analyses revealed that Divinity typically co‐occurred with Autonomy in these conversations and that such co‐occurrences typically happened through three distinct social‐communicative processes, labeled “align,” “scaffold,” and “counter.” Findings are used to explain the shifting priority of Autonomy and Divinity over the life course among members of evangelical Christian faiths that previous research has documented. More broadly, findings highlight socialization processes through which children can rationalize their developing moral outlooks in culturally distinct ways.
Whole exome sequencing identified a novel single base pair insertion mutation in the EYS gene in a six generation family with retinitis pigmentosa
Authors: Hashmi Jamil Amjad , Albarry Maan Abdullah , Almatrafi Ahmed M. , Albalawi Alia M. , Mahmood Amer , Basit Sulman 
Published: April 2017

AbstractRetinitis pigmentosa (RP) is a group of inherited progressive retinal dystrophies (RD) and is characterized by photoreceptor degeneration. RP is clinically and genetically heterogeneous disorder. More than 70 genes are known and, thus, identification of causative genes and mutations in known genes is challenging. This study was designed to identify the underlying genetic defect in a large extended Saudi family with multiple RP affected members. Fundus photography, Optical Coherence Tomography (OCT) and visual field perimetry were performed for affected individuals. Whole exome sequencing was used to detect the underlying genetic defect in a large family with 12 affected individuals showing autosomal recessive isolated RP. WES data analysis identified a novel insertion mutation in the EYS (eyes shut homolog) gene (c.910_911insT; p.Trp304LeufsTer8). Sanger sequencing validates the variant discovered through exome in all 12 affected individuals and showed that this mutation is segregating with RP phenotype in an autosomal recessive manner in 51 individuals of the family tested here. Our study expands the mutation spectrum of EYS gene in RP patients and extends the body of evidence that supports the importance of EYS gene in eye development.
Role of monocyte tissue factor on patients with non‐small cell lung cancer
Authors: Deng Chaosheng , Wu Shuang , Zhang Lina , Yang Minxia , Lin Qichang , Xie Qiang , Ding Haibo , Lian Ningfang , Gao Shaoyong , Huang Yunjian , Jin Yongxu 
Published: April 2017

AbstractBackgroundTo examine the expression of D‐dimer, fibrinogen (FIB), leukocyte, C‐reactive protein (CRP) and tissue factor (TF) released from monocyte in non‐small cell lung cancer (NSCLC) patients with or without venous thromboembolism (VTE) and analyse the correlation, to explore the possible mechanisms.MethodsSeventy‐two patients confirmed the diagnosis of lung cancer, among whom 10 with VTE were enrolled into the study from November 2012 to January 2014 in the First Affiliated Hospital of Fujian Medical University and 30 healthy subjects were also enrolled as the control group. Ficoll and Percoll density gradient centrifugation separated of peripheral blood monocyte. Monocyte TF mRNA expression was detected using reverse transcriptase‐polymerase chain reaction (RT‐PCR).ResultsThere were significant differences in different stages of the cancer (P < .05) and no significance among the histopathologic types (P > .05) for the expression of monocyte TF mRNA in NSCLC patients, its expression was significantly higher in cancer with lymph node metastasis than those without lymph node metastasis (P < .01). Meanwhile, in NSCLC patients with VTE, the expression of monocyte TF mRNA was significantly higher than that in patients without VTE (P < .01). Difference of the survival curves between the low monocyte TF mRNA expression and the high monocyte TF mRNA expression was significant (Log‐rank x2 = 4.923, P < .05).ConclusionsMonocyte TF may be a relevant source of TF‐mediated thrombogenicity in NSCLC patients and may be associated with prognosis in NSCLC.
Pulmonary hypertension associated with combined fibrosing mediastinitis and bronchial anthracofibrosis: A retrospective analysis in a single Chinese hospital
Authors: Xu Yan , Xu Wenbing , Liu Yongjian , Tian Xinlun , Xu Kaifeng , Shi Juhong , Wang Mengzhao , Cai Baiqiang , Peng Min 
Published: April 2017

AbstractIntroductionBoth fibrosing mediastinitis (FM) and bronchial anthracofibrosis (BAF) are unique diseases. The combined appearance of FM and BAF is extremely rare.ObjectivesThe aim of this study was to investigate the clinical features of patients with coexisting FM and BAF.MethodBetween January 2003 and December 2015, a total of eight patients were diagnosed at the Peking Union Medical College Hospital as having combined FM and BAF. The clinical presentations, radiographic features and bronchoscopic findings of the eight patients were reviewed.ResultsThe patients were five women and three men with a median age of 64 years (range 56‐86 years). Symptoms included dyspnea (eight patients), cough (seven patients), chest pain (two patients), hemoptysis (two patients) and so on. Chest CT of all eight patients showed mediastinal soft‐tissue lesions, with multiple narrowed or obliterated lobar or segmental bronchi and arteries. Bronchoscopy showed that all of the patients had multiple stenoses of lobar or segmental bronchi with anthracotic pigmentation on the mucosa. Echocardiography showed that all of the patients had elevated pulmonary arterial systolic pressure (median 81 mm Hg, range 51‐107 mm Hg). Each of the eight patients had a history of exposure to, or infection with, tuberculosis, although there was no evidence of active disease. All of the eight patients had long‐term exposure to indoor coal or biomass fuel smoke.ConclusionsFM can coexist with BAF, characterized by prominent pulmonary hypertension. The possible etiological factors are tuberculosis and coal or biomass fuel exposure.