bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age‐related new bone formation following the use of cancellous bone‐block allografts for reconstruction of atrophic alveolar ridges
Authors: Nissan Joseph , Kolerman Roni , Chaushu Liat , Vered Marilena , Naishlos Sarit , Chaushu Gavriel 
Published: December 2017

AbstractBackgroundAn age‐related decrease in the number of osteogenic progenitor cells may compromise bone augmentation.PurposeHistomorphometrical assessment of age‐related new bone formation, following atrophic alveolar ridge reconstruction, using cancellous bone‐block allografts.Material and methodsNinety‐three consecutive patients (58 females and 35 males) were referred for implant‐supported restoration of 122 severe atrophic alveolar ridges. Alveolar ridge deficiency locations were classified as anterior maxilla (n = 58), posterior maxilla (n= 32), and posterior mandible (n = 32). A bony deficiency of at least 3 mm horizontally and up to 3 mm vertically according to computerized tomography (CT) in the posterior mandible and anterior maxilla, served as inclusion criteria. In the posterior maxilla, a residual alveolar ridge up to 4 mm vertically according to CT served as inclusion criteria. Augmentation was performed by the use of cancellous bone‐block allografts. Bone biopsies (9‐month posterior maxilla, 4 months anterior maxilla and posterior mandible) of young (≤40 years) versus older (>40 years) patients were histomorphometrically evaluated.ResultsIn the posterior maxilla, no statistically significant histomorphometric differences were noted. While at the anterior maxilla and posterior mandible, statistically significant more newly formed bone was found in young versus older individuals, respectively (38.6% vs 19.8%, P = 0.04 and 69% vs 31%, P = .05).ConclusionNew bone formation following residual alveolar ridge bone grafting is age‐related. Longer bone consolidation and healing time may be recommended for older individuals.
Stereotype Threat Effects on Learning From a Cognitively Demanding Mathematics Lesson
Authors: Lyons Emily McLaughlin , Simms Nina , Begolli Kreshnik N. , Richland Lindsey E. 
Published: December 2017

AbstractStereotype threat—a situational context in which individuals are concerned about confirming a negative stereotype—is often shown to impact test performance, with one hypothesized mechanism being that cognitive resources are temporarily co‐opted by intrusive thoughts and worries, leading individuals to underperform despite high content knowledge and ability (see Schmader & Beilock, ). We test here whether stereotype threat may also impact initial student learning and knowledge formation when experienced prior to instruction. Predominantly African American fifth‐grade students provided either their race or the date before a videotaped, conceptually demanding mathematics lesson. Students who gave their race retained less learning over time, enjoyed the lesson less, reported a diminished desire to learn more, and were less likely to choose to engage in an optional math activity. The detrimental impact was greatest among students with high baseline cognitive resources. While stereotype threat has been well documented to harm test performance, the finding that effects extend to initial learning suggests that stereotype threat's contribution to achievement gaps may be greatly underestimated.
Evolution of lung and kidney allograft function in patients receiving kidney after lung transplantation
Authors: Weber Nina T. , Bonani Marco , Benden Christian , Schleich Andreas , Fehr Thomas , Mueller Thomas F. , Schuurmans Macé M. 
Published: December 2017

AbstractCalcineurin inhibitor (CNI) toxicity leads to end‐stage renal disease in almost half of long‐term survivors after lung transplantation, some of them receiving kidney transplants. Little is known about the outcomes of kidney and lung allograft function following kidney after lung transplantation (KALTPL) in the modern era. We retrospectively analyzed a group of 13 consecutive patients who received a KALTPL with respect to their renal and pulmonary function and immunological evolution over 2 years. We documented a stable evolution of forced expiratory volume in 1 second (FEV1) after KALTPL in most patients as well as an excellent kidney graft during the 2‐year follow‐up period. In our small cohort, living donations showed a significantly higher estimated glomerular filtration rate compared to deceased donation (75.7 compared to 41.6 mL/min). Patients who received a preemptive KALTPL were more likely to improve their lung function after KALTPL. Four patients developed de novo donor‐specific antibodies (DSA) against the kidney graft. There were no DSA against shared antigens from the lung allograft. De novo DSA did not lead to graft loss in any patient. All 13 patients survived the first 24 months after KALTPL.
Cholinesterase levels predict exercise capacity in cardiac recipients early after transplantation
Authors: Kitagaki Kazufumi , Nakanishi Michio , Ono Rei , Yamamoto Kazuya , Suzuki Yuji , Fukui Noriyuki , Yanagi Hidetoshi , Konishi Harumi , Yanase Masanobu , Fukushima Norihide 
Published: December 2017

AbstractPurposeAlthough cardiac rehabilitation is recommended for patients early after heart transplantation (HTx), adequate exercise effect cannot always be obtained, partly because in patients with chronic heart failure, exercise capacity is reduced due to malnutrition while waiting for HTx. This study aimed to investigate the relationships between exercise capacity and clinical variables, including nutritional indicators, early after HTx.Patients and MethodsForty‐three HTx recipients were studied. The mean age at HTx was 38 ± 14 years, and 86% were male. We assessed the relationships between peak oxygen uptake (VO2) and clinical variables, including plasma B‐type natriuretic peptide (BNP), isometric knee extensor muscle strength (KEMS), and nutritional indicators within 1 week of their respective discharges.ResultsPeak VO2 correlated positively with isometric KEMS (r = .63, P < .0001) and negatively with BNP level (r = −.37, P = .015). Of the nutritional indicators, only cholinesterase levels had a significant relationship with peak VO2 (r = .34, P = .028), whereas the Geriatric Nutritional Risk Index and the Controlling Nutritional Status scores did not. In multiple linear regression analysis, cholinesterase levels and isometric KEMS were independent predictors of peak VO2.ConclusionCholinesterase levels predicted exercise capacity early after HTx.
A modified normal strain ratio fatigue life model based on the hybrid approach of critical plane and crystallographic slip theory
Authors: Mu L.J. , Dong X.Z. , Gao Q. , Tan C.Q. 
Published: December 2017

AbstractBased on the method combining the critical plane with crystallographic slip theory, an anisotropic low cycle fatigue life model is proposed to reflect the effects of orientation dependence and damage factors on fatigue life. According to this method, the crystallographic slip plane is adopted as the critical plane by searching for 30 potential slip systems. In addition, considering the effects of normal strain and strain ratio on fatigue failure, the normal strain ratio is introduced into model and regression model is obtained by fitting method. The proposed model is verified by estimating the low cycle fatigue lives of single crystal nickel–based superalloys PWA1480, CMSX‐2 and DD3 for different loading conditions. The results show that the proposed model is applicable for more complicated loading situations and give a higher prediction accuracy compared to Sun's model.
Dispersal barriers and climate determine the geographic distribution of the helicopter damselfly Mecistogaster modesta
Authors: Amundrud Sarah L. , Videla Martin , Srivastava Diane S. 
Published: December 2017

Abstract

Species’ ranges are typically constrained by the interplay of physical barriers to dispersal, environmental requirements such as suitable climatic conditions and biotic constraints such as from predation or competition. However, teasing apart the relative importance of these constraints in determining species distributions still represents a major challenge for ecologists.

The Neotropical damselfly Mecistogaster modesta (Coenagrionidae: Odonata) inhabits wet and moist forests in mainland Central America and north‐western South America. This habitat specialist spends its larval development exclusively in tank bromeliads, where it acts as a keystone predator within the aquatic food web. Although tank‐forming bromeliads occur from the southern United States throughout most of South America, M. modesta is absent from the Caribbean islands and South America south‐east of the Andes mountain chain.

We employed species distribution models to explore the relative importance of physical barriers (Andes mountain range and oceanic barriers), climate (mean annual temperature and annual precipitation) and biotic interactions (competition from other bromeliad‐dwelling odonates) in limiting the geographic distribution of M. modesta.

We found that dispersal barriers strongly limit the geographic distribution of M. modesta. In addition, its range is restricted by low temperatures and low precipitation. Competition from other bromeliad‐dwelling odonates was not important in limiting the damselfly's range. Because of the physical barriers to dispersal, M. modesta does not occupy its full potential geographic range. Specifically, our model predicted suitable habitat on the Caribbean islands and throughout most of South America, where the species is currently absent.

These findings have important conservation implications, particularly as the aridification of rainforests and subsequent localised extinctions due to climate change continue. On the other hand, the species may respond to warming temperatures by tracking climate to higher elevations, with subsequent effects on naïve high‐elevation bromeliad food webs. An upwards migration could also increase the probability of M. modesta overcoming the dispersal barrier presented by the Andes, enabling the damselfly to invade large areas of suitable habitat in South America.
TESTING FOR SPECULATIVE BUBBLES USING SPOT AND FORWARD PRICES
Authors: Pavlidis Efthymios G. , Paya Ivan , Peel David A. 
Published: December 2017

AbstractThe probabilistic structure of periodically collapsing bubbles creates a gap between future spot and forward (futures) asset prices in small samples. By exploiting this fact, we use a recently developed recursive unit root test and rolling Fama regressions for detecting bubbles. Both methods do not rely on a particular model of asset price determination, are robust to explosive fundamentals, and allow date stamping. An application to U.S. dollar exchange rates provides evidence of bubbles during the interwar German hyperinflation, but not during the recent floating‐rate period. A further application to S&P 500 supports the existence of bubbles in the U.S. equity market.
TESTING STRICT STATIONARITY WITH APPLICATIONS TO MACROECONOMIC TIME SERIES
Authors: Hong Yongmiao , Wang Xia , Wang Shouyang 
Published: December 2017

AbstractWe propose a model‐free test for strict stationarity. The idea is to estimate a nonparametric time‐varying characteristic function and compare it with the empirical characteristic function based on the whole sample. We also propose several derivative tests to check time‐invariant moments, weak stationarity, and pth order stationarity. Monte Carlo studies demonstrate excellent power of our tests. We apply our tests to various macroeconomic time series and find overwhelming evidence against strict and weak stationarity for both level and first‐differenced series. This suggests that the conventional time series econometric modeling strategies may have room to be improved by accommodating these time‐varying features.
Outcomes of indwelling metallic stents for malignant extrinsic ureteral obstruction
Authors: Asakawa Jumpei , Iguchi Taro , Tamada Satoshi , Ninomiya Noriko , Kato Minoru , Yamasaki Takeshi , Nakatani Tatsuya 
Published: December 2017

ObjectivesTo report the treatment outcomes of patients with extrinsic ureteral obstruction treated with metallic stents and to identify the factors predicting stent failure.MethodsA total of 52 patients with extrinsic ureteral obstruction as a result of malignancy (66 ureters) were treated with metallic stents (Resonance®) and included in the study. The median observation period was 118 days.ResultsThe median survival time of these patients was 210 days, and the stent patency rate was 86.0% at 6 months and 60.0% at 1 year. Eight (15.4%) patients underwent nephrostomy as a result of stent failure. The occlusion rate of bilateral ureteral obstructed cases was significantly higher than that of unilateral cases. There was no correlation between the preoperative serum creatinine level, causes of ureteral occlusions (compression by tumor, lymph node metastasis, peritoneal dissemination), obstructed site (upper, middle, lower ureter) and stent failure.ConclusionsMetallic stents are excellent in maintaining patency compared with the conventional stents. Therefore, they can be used as first‐line treatment of malignant ureteral obstructions.
Evaluating effectiveness in adolescent mental health inpatient units: A systematic review
Authors: Hayes Claire , Simmons Magenta , Simons Christine , Hopwood Malcolm 
Published: December 2017

AbstractAdolescent mental health research is a developing area. Inpatient units are the most widely used acute element of adolescent mental health services internationally. Little is known about inpatient units, particularly when it comes to measuring improvement for adolescents. Clinical outcome measurement in the broad context has gathered momentum in recent years, driven by the need to assess services. The measurement of outcomes for adolescents who access inpatient care is critical, as they are particularly vulnerable and are often considered the most difficult to treat. Following the PRISMA guidelines, the aim of this review was to assess whether adolescent inpatient units are effective and understand how outcomes are measured. CINAHL, MEDLINE with Full Text, ERIC, PsycINFO, and Cochrane databases were systematically searched. Studies were included if the inpatient units were generic and adolescents were between the mean age of 12‐25 years. Furthermore, studies published in English within the last ten years were included. Exclusions were outpatient and disorder‐specific inpatient settings. A total of 16 studies were identified. Each study demonstrated effectiveness on at least one outcome measure in terms of symptom stabilization. However, several outcome measures were used and therefore inpatient units lack consistency in how they measure improvement. Inpatient units are effective for the majority of young people as they result in symptom stabilization. Whilst symptom stabilization can be achieved, future research examining the mechanism of change is needed.
Solving the bi‐objective capacitated p‐median problem with multilevel capacities using compromise programming and VNS
Authors: Irawan Chandra Ade , Imran Arif , Luis Martino 
Published: December 2017

AbstractA bi‐objective optimisation using a compromise programming (CP) approach is proposed for the capacitated p‐median problem (CPMP) in the presence of the fixed cost of opening facility and several possible capacities that can be used by potential facilities. As the sum of distances between customers and their facilities and the total fixed cost for opening facilities are important aspects, the model is proposed to deal with those conflicting objectives. We develop a mathematical model using integer linear programming (ILP) to determine the optimal location of open facilities with their optimal capacity. Two approaches are designed to deal with the bi‐objective CPMP, namely CP with an exact method and with a variable neighbourhood search (VNS) based matheuristic. New sets of generated instances are used to evaluate the performance of the proposed approaches. The computational experiments show that the proposed approaches produce interesting results.
Analysis of arrhythmic events is useful to detect lead failure earlier in patients followed by remote monitoring
Authors: Nishii Nobuhiro , Miyoshi Akihito , Kubo Motoki , Miyamoto Masakazu , Morimoto Yoshimasa , Kawada Satoshi , Nakagawa Koji , Watanabe Atsuyuki , Nakamura Kazufumi , Morita Hiroshi , Ito Hiroshi 
Published: December 2017

AbstractBackgroundRemote monitoring (RM) has been advocated as the new standard of care for patients with cardiovascular implantable electronic devices (CIEDs). RM has allowed the early detection of adverse clinical events, such as arrhythmia, lead failure, and battery depletion. However, lead failure was often identified only by arrhythmic events, but not impedance abnormalities.ObjectiveTo compare the usefulness of arrhythmic events with conventional impedance abnormalities for identifying lead failure in CIED patients followed by RM.MethodsCIED patients in 12 hospitals have been followed by the RM center in Okayama University Hospital. All transmitted data have been analyzed and summarized.ResultsFrom April 2009 to March 2016, 1,873 patients have been followed by the RM center. During the mean follow‐up period of 775 days, 42 lead failure events (atrial lead 22, right ventricular pacemaker lead 5, implantable cardioverter defibrillator [ICD] lead 15) were detected. The proportion of lead failures detected only by arrhythmic events, which were not detected by conventional impedance abnormalities, was significantly higher than that detected by impedance abnormalities (arrhythmic event 76.2%, 95% CI: 60.5–87.9%; impedance abnormalities 23.8%, 95% CI: 12.1–39.5%). Twenty‐seven events (64.7%) were detected without any alert. Of 15 patients with ICD lead failure, none has experienced inappropriate therapy.ConclusionsRM can detect lead failure earlier, before clinical adverse events. However, CIEDs often diagnose lead failure as just arrhythmic events without any warning. Thus, to detect lead failure earlier, careful human analysis of arrhythmic events is useful.
Association of metabolic syndrome with carotid thickening and plaque in the general population: A meta‐analysis
Authors: Cuspidi Cesare , Sala Carla , Tadic Marijana , Gherbesi Elisa , Grassi Guido , Mancia Giuseppe 
Published: December 2017

We performed a meta‐analysis of population studies reporting data on carotid intima‐media thickness and plaque in patients with and without metabolic syndrome (MetS) to provide a new piece of information on the relationship of MetS with both phenotypes of vascular damage. The Ovid MEDLINE, PubMed, and Cochrane CENTRAL databases were searched without time restriction up to December 31, 2016. Overall, 19 696 patients (22.2% with MetS) were included in eight studies. Common carotid intima‐media thickness was greater in patients with MetS compared with those without it (788 ± 47 μm vs 727 ± 44 μm), with a standard means difference of 0.28 ± 0.06 (P = .00003). Increased intima‐media thickness in patients with MetS was paralleled by a higher prevalence of plaques. The present meta‐analysis shows that MetS is associated with both ultrasonographic phenotypes of carotid damage. This finding is consistent with the view of MetS as a cluster of hemodynamic and nonhemodynamic factors promoting vascular hypertrophy and plaque.
Microneedling for the treatment of hair loss?
Authors: Fertig R.M. , Gamret A.C. , Cervantes J. , Tosti A. 
Published: December 2017

AbstractMicroneedling is a minimally invasive dermatological procedure in which fine needles are rolled over the skin to puncture the stratum corneum. This therapy is used to induce collagen formation, neovascularization and growth factor production of treated areas. It has been used in a wide range of dermatologic conditions, including androgenetic alopecia (AGA) and alopecia areata, among others. While there are a limited number of studies examining this therapy in the use of hair loss, microneedling has been successfully paired with other hair growth promoting therapies, such as minoxidil, platelet‐rich plasma and topical steroids, and shown to stimulate hair follicle growth. It is thought that microneedling facilitates penetration of such first‐line medications, and this is one mechanism by which it promotes hair growth. To date, the area most studied and with the most success has been microneedling treatment of AGA. While the current evidence does not allow one to conclude superiority of microneedling over existing standard therapies for hair loss, microneedling shows some promise in improving hair growth, especially in combination with existing techniques. This review summarizes the current literature regarding microneedling in the treatment of alopecia and calls for further studies to define a standard treatment protocol.
How complex is your love? The case of romantic compromises and polyamory
Authors: Ben‐Ze’ev Aaron , Brunning Luke 
Published: December 2017

AbstractThis article highlights a somewhat neglected aspect of love (and of emotions in general): their complexity. We suggest distinguishing between three major related types of emotional complexity: emotional diversity, emotional ambivalence, and emotional behavior. The notion of emotional complexity has far‐reaching implications for understanding emotions and our wellbeing. This is illustrated by examining the notion of emotional complexity in two common yet complex phenomena in the romantic realm: romantic compromises and polyamory.
Delayed viral suppression during antiviral therapy is associated with increased hepatocellular carcinoma rates in HBeAg‐positive high viral load chronic hepatitis B
Authors: Nam J. Y. , Chang Y. , Cho H. , Kang S. H. , Cho Y. Y. , Cho E. J. , Lee J.‐H. , Yu S. J. , Yoon J.‐H. , Kim Y. J. 
Published: December 2017

SummaryThe treatment option in chronic hepatitis B (CHB) patients with persistent low‐level viremia despite entecavir or tenofovir monotherapy is unclear. This study investigated the development of hepatocellular carcinoma (HCC) or cirrhosis in hepatitis B e antigen (HBeAg)‐positive high viral load CHB patients, according to the time needed to achieve complete viral suppression. A total of 325 HBeAg‐positive CHB patients with high viral load who were recently started on antiviral therapy with entecavir or tenofovir were included. The enrolled patients were divided into 2 groups with 4 separate criteria based on the time needed to achieve complete viral suppression: within 1, 2, 3 or 4 years of therapy initiation. The outcomes were development of HCC and cirrhosis. The cumulative incidence of HCC was significantly higher in patients failing complete viral suppression within 1 year (hazard ratio (HR), 4.54; 95% confidence interval (CI), 1.03‐19.93; P = .045) or 2 years (HR, 3.38; 95% CI, 1.24‐9.23; P = .018), than patients who achieved complete viral suppression within 1 or 2 years, respectively. Cumulative incidence of cirrhosis was also significantly higher in patients failing suppression within 1 year (HR, 1.95; 95% CI, 1.04‐3.66; P = .037) or 2 years (HR, 2.44; 95% CI, 1.41‐4.22; P = .001). When the time for achieving viral suppression exceeded 2 years, the cumulative incidence of HCC or cirrhosis was not different regardless of viral suppression. Complete hepatitis B virus suppression within 2 years of antiviral therapy initiation is associated with risk reduction in HCC or cirrhosis development.