bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endothelial progenitor cells as markers of severity in hypertrophic cardiomyopathy
Authors: Kalyva Athanasia , Marketou Maria E. , Parthenakis Fragiskos I. , Pontikoglou Charalampos , Kontaraki Joanna E. , Maragkoudakis Spyros , Petousis Stylianos , Chlouverakis Gregory , Papadaki Helen A. , Vardas Panos E. 
Published: December 2015

AbstractAimsEndothelial progenitor cells (EPCs) are bone marrow‐derived cells that are mobilized into the circulation to migrate and differentiate into mature endothelial cells contributing to post‐natal physiological and pathological neovascularization. In this study, we evaluated circulating EPCs in patients with hypertrophic cardiomyopathy (HCM) and examined a potential association with clinical parameters of the disease.Methods and resultsWe included 40 HCM patients and 23 healthy individuals. Using flow cytometry we measured EPCs in peripheral blood as two subpopulations of CD45–/CD34+/VEGFR2+ and CD45–/CD34+/CD133+ cells. Circulating CD45–/CD34+/VEGFR2+ cells were significantly increased in HCM patients in comparison with the controls (0.000238 ± 0.0003136 vs. 0.000057 ± 0.0001316, respectively, P = 0.002). However, there was no significant difference in the number of circulating CD45–/CD34+/CD133+ cells (0.003079 ± 0.0033288 vs. 0.002065 ± 0.0022173, respectively, P = 0.153). The CD45–/CD34+/VEGFR2+ subpopulation revealed a moderate correlation with LV mass index (r = 0.35, P = 0.026), while both EPC subpopulation levels showed strong positive correlations with th E/e' ratio (r = 0.423, P = 0.007 for CD45–/CD34+/VEGFR2+ and r = 0.572, P < 0.001 for CD45–/CD34+/CD133+).ConclusionHCM patients showed an increased mobilization of EPCs compared with healthy individuals that correlated with diastolic dysfunction. Our findings may open up new dimensions in the pathophysiology, prognostication, and treatment of HCM.
Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction
Authors: Damman Kevin , Kjekshus John , Wikstrand John , Cleland John G.F. , Komajda Michel , Wedel Hans , Waagstein Finn , McMurray John J.V. 
Published: December 2015

AimWe aimed to study the relationships of loop diuretic dose with renal function and clinical outcomes in patients with chronic heart failure (HF).Methods and resultsLoop diuretic dose at baseline was recorded in patients included in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). The relationship to change in estimated glomerular filtration rate (eGFR) over time and to the first occurrence of the composite outcome of cardiovascular (CV) death or hospitalization owing to HF was examined in propensity score matched cohorts. Of the 5011 patients, 2550, 745, and 449 were receiving >80 mg (high), 41–80 mg (medium) and ≤40 mg (low) of loop diuretics in furosemide equivalent daily dosages, respectively, which were used to assemble 229, 385, and 1045 pairs of propensity‐matched high, medium, and low dose cohorts. Compared with matched no loop diuretic groups, eGFR declined 0.3 ± 0.2, 0.3 ± 0.3 and 1.2 ± 0.5 mL/min/1.73 m2/year in the low‐, medium‐, and high‐dose groups, respectively. Compared with matched no loop diuretic groups, hazard ratios (HR) (95% confidence intervals) for outcome associated with low‐, medium‐ and high‐dose groups were 1.71 (1.41–2.06), 1.99 (1.50–2.64), and 2.94 (1.95–4.41), respectively. Higher loop diuretic dose was particularly associated with increased risk for hospitalization owing to HF: HR 4.80 (2.75–8.37), P < 0.001.ConclusionsThe use of loop diuretics was associated with a slightly greater rate of decline in eGFR, which did not vary significantly by diuretic dose.Loop diuretic dose was associated with higher risks of (CV) mortality and predominantly hospitalization owing to HF, which appeared to be higher among those receiving higher daily doses.
Preparation of Imidazol‐2‐ylidene Carbene Palladacycles with Bi‐ and Tridentate Schiff Bases – Analyses of the Spectroscopic, Molecular Structure, and DFT Calculation Data
Authors: Naya Leticia , Vázquez‐García Digna , Fernández Alberto , López‐Torres Margarita , Ojea Vicente , Marcos Ismael , Vila José M. , Fernández Jesús J. 
Published: December 2015

AbstractThe treatment of appropriate benzylideneimine palladacycles with potentially polydentate imidazol‐2‐ylidene silver carbene complexes produced new palladium organometallics with the N‐heterocyclic carbene (NHC) coordinated to the palladium center. The NHCs bearing two carbene moieties show a bridging coordination mode across the two metal atoms and may also display a simultaneous bridging/chelating behavior. DFT calculations were performed for the compounds for which the typical fluxional behavior of hemilabile carbenes was observed upon close inspection of the 1H NMR spectra. The crystal and molecular structure of 13 was determined by X‐ray crystallography and contrasted against the computational data for 14 to determine the most favorable disposition of the fluxional equilibrium of the latter.
Iridium(III) 2‐Phenylbenzimidazole Complexes: Synthesis, Structure, Optical Properties, and Applications in Dye‐Sensitized Solar Cells
Authors: Bezzubov Stanislav I. , Kiselev Yuri M. , Churakov Andrey V. , Kozyukhin Sergey A. , Sadovnikov Alexey A. , Grinberg Vitaly A. , Emets Viktor V. , Doljenko Vladimir D. 
Published: December 2015

AbstractA series of bis‐cyclometalated iridium(III) complexes, [Ir(LH)2(H2dcbpy)][PF6] (1), [Ir(LMe)2(H2dcbpy)][PF6] (2), and [Ir(LPh)2(H2dcbpy)][PF6] (3), where LH = 1‐H‐2‐phenylbenzimidazole, LMe = 1‐methyl‐2‐phenylbenzimidazole, LPh = 1,2‐diphenylbenzimidazole, and H2dcbpy = 2,2′‐bipyridine‐4,4′‐dicarboxylic acid, has been synthesized and fully characterized by elemental analysis, 1H and 31P NMR spectroscopy, mass spectrometry, and single‐crystal X‐ray analysis. The complexes show strong luminescence in the yellow–orange region in ethanol at room temperature (quantum yield is up to 22 %), and absorb light up to 550 nm with molar absorptivities of 1500–2000 M–1 cm–1. Complexes 1 and 2 possess very similar optical properties, whereas the introduction of the phenyl ring (complex 3) causes a hypsochromic shift (≈ 30 nm) of the luminescent maximum as well as resulting in an almost 50 % increase in the extinction coefficient at 490 nm compared with 1 and 2. A dye‐sensitized solar cell (DSSC) based on complex 3 exhibits a short‐circuit photocurrent of 2.8 mA cm–2, an open‐circuit photovoltage of 0.44 V, and a power conversion efficiency of 0.7 %.
Influence of Reinforcing Nonagglomerated Nanodiamond Particles on Metal Matrix Nanocomposite Structure Stability in the Course of Heat­ing
Authors: Popov Vladimir A. , Shelekhov Evgenij V. , Vershinina Ekaterina V. 
Published: December 2015

AbstractWe show that the use of mechanical alloying makes it possible to produce metal matrix composites with uniformly distributed nonagglomerated nanodiamond (ND) reinforcing particles. An aluminium matrix has been used for this study. X‐ray analysis shows that a composite structure containing uniformly distributed nanoparticles of 4–6 nm can significantly slow down the process of recrystallization during heating, which becomes evident only when the material is heated above 350 °C. Higher volume fractions of diamond nanoparticles lead to higher starting recrystallization temperatures.
Hierarchical Meso‐Mesoporous and Macro‐Mesoporous Silica Templated by Mixtures of Polyoxyethylene ­Fluoroalkyl Ether and Triblock Copolymer
Authors: May‐Masnou Anna , Stébé Marie José , Blin Jean Luc 
Published: December 2015

AbstractWe report here the synthesis of different kinds of hierarchical porous silica materials by using mixtures of an amphiphilic block copolymer (Pluronic P123) and a nonionic fluorinated surfactant. In particular, we have taken advantage of the difference in polarities between the two compounds to design dual‐mesoporous materials through the cooperative templating mechanism (CTM). We have undertaken a complete study of this system by varying the composition of the mixed micelles and the synthesis conditions. We have shown that both the dual‐mesoporosity and the mesopore ordering are favored when materials are prepared with fluorine‐rich and P123‐rich micelles. However, when the P123‐rich micelles predominate, the mesostructure is less organized and the dual‐porosity depends on the P123 content. In addition, concentrated emulsions were formed by incorporating perfluorodecalin (PFD) in the surfactant mixture, and hierarchical macro‐mesoporous materials were prepared by combining the CTM and the emulsion templating mechanism.
Chiral Copper(II) Bis(oxazoline) Complexes Directly Coordinated to Amine‐Functionalized Phenylene/Biphenylene Periodic Mesoporous Organosilicas as Heterogeneous ­Catalysts
Authors: Carneiro Liliana , Silva Ana Rosa , Lourenço Mirtha A. O. , Mayoral Alvaro , Diaz Isabel , Ferreira Paula 
Published: December 2015

AbstractCopper(II) complexes with commercial chiral bis(oxazoline)s were for the first time directly coordinated onto amine‐modified mesoporous phenylene and biphenylene silicas. All final materials maintained the 2D ordered mesoporous structure. The copper metal coordinates directly to the amine groups within the walls of the materials. The materials were tested as asymmetric heterogeneous catalysts in the kinetic resolution of hydrobenzoin. They were active, selective, and enantioselective in this reaction. The material containing the (S)‐(–)‐2,2′‐isopropylidene‐bis(4‐phenyl‐2‐oxazoline) (Me2PhBox) ligand, the best ligand in the homogeneous phase, presented the highest enantioselectivity of all the materials in the first cycle (73 %). The 2,2′‐methylenebis[(4S)‐4‐phenyl‐2‐oxazoline] (PhBox) ligand rendered the catalyst more stable, independent of the anion or organic moiety in the periodic mesoporous organosilica material; this catalyst was reused over five cycles without any significant loss of catalytic activity or enantioselectivity. This type of ligand plays an important role in the stability of the corresponding copper(II) complex upon immobilization and in the robustness of the heterogeneous catalyst upon reuse.
Nickel‐Catalyzed Reductive Addition of Aryl/Benzyl Halides and Pseudohalides to Carbodiimides for the Synthesis of Amides
Authors: Panahi Farhad , Jamedi Fereshteh , Iranpoor Nasser 
Published: December 2015

AbstractA Nickel‐catalyzed reductive process is described for the direct amidation of benzyl and aryl halides using carbodiimides as the amidating agent. Moreover, aryl and benzyl C–O electrophiles such as triflate, acetate, tosylate, trityl ether, and pivalate were converted into amides using this method. The in‐situ‐generated Ni0 acts as a catalyst for the reaction at room temperature for benzylic substrates, and 70 °C for aryl electrophiles. This new nickel‐catalyzed reductive coupling protocol provides a general and operationally simple method for the synthesis of diverse amides using carbodiimides. Amides bearing bulky substituents can be synthesized by this strategy in high yield, which demonstrates its effectiveness in amide synthesis.
Fluorescent Probes from Stable Aromatic Nitrile Oxides
Authors: Minuti Luigi Ferdinando , Memeo Misal Giuseppe , Crespi Stefano , Quadrelli Paolo 
Published: December 2015

AbstractStable aromatic nitrile oxides underwent a 1,3‐dipolar cycloaddition reaction with 1‐iodo‐4‐(prop‐2‐yn‐1‐yloxy)benzene to afford the expected isoxazoles in very good yields as single regioisomers. The formation of the 5‐substituted isoxazoles is in agreement with frontier orbital theory. The reductive cleavage of the N–O bond followed by complexation with BF3·Et2O afforded the corresponding boron complexes, which were further derivatized with a triple bond for click chemistry applications. The photochemical behavior and the fluorescence properties of the derivatives were investigated and discussed, taking theoretical calculations into consideration.
Two‐year Follow‐up of a Pragmatic Randomised Controlled Trial Examining the Effect of Adding a Carer's Skill Training Intervention in Inpatients with Anorexia Nervosa
Authors: Magill Nicholas , Rhind Charlotte , Hibbs Rebecca , Goddard Elizabeth , Macdonald Pamela , Arcelus Jon , Morgan John , Beecham Jennifer , Schmidt Ulrike , Landau Sabine , Treasure Janet 
Published: December 2015

AbstractBackgroundActive family engagement improves outcomes from adolescent inpatient care, but the impact on adult anorexia nervosa is uncertain.AimThe aim of this study was to describe the 2‐year outcome following a pragmatic randomised controlled trial in which a skill training intervention (Experienced Caregivers Helping Others) for carers was added to inpatient care.MethodPatient, caregiver and service outcomes were measured for 2 years following discharge from the index inpatient admission.ResultsThere were small‐sized/moderate‐sized effects and consistent improvements in all outcomes from both patients and carers in the Experienced Caregivers Helping Others group over 2 years. The marked change in body mass index and carers' time caregiving following inpatient care was sustained. Approximately 20% of cases had further periods of inpatient care.ConclusionIn this predominately adult anorexia nervosa sample, enabling carers to provide active support and management skills may improve the benefits in all symptom domains that gradually follow from a period of inpatient care. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
Quality attributes of sweet potato flour as influenced by variety, pretreatment and drying method
Authors: Olatunde Ganiyat O. , Henshaw Folake O. , Idowu Michael A. , Tomlins Keith 
Published: December 2015

AbstractThe effect of pretreatment methods (soaking in water, potassium metabisulphite solution, and blanching) and drying methods (sun and oven) on some quality attributes of flour from ten varieties of sweet potato roots were investigated. The quality attributes determined were chemical composition and functional properties. Data obtained were subjected to descriptive statistics, multivariate analysis of variance, and Pearson's correlation. The range of values for properties of sweet potato flour were: moisture (8.06–12.86 ± 1.13%), starch (55.76–83.65 ± 6.82%), amylose (10.06–21.26 ± 3.92%), total sugar (22.39–125.46 ± 24.68 μg/mg), water absorption capacity (140–280 ± 26), water solubility (6.89–26.18 ± 3.80), swelling power (1.66–5.00 ± 0.50), peak viscosity (24.50–260.92 ± 52.61 RVU), trough (7.08–145.83 ± 34.48 RVU), breakdown viscosity (11.00–125.33 RVU), final viscosity (10.21–225.50 ± 60.55 RVU), setback viscosity (3.04–92.21 RVU), peak time (6.07–9.06 min) and pasting temperature (69.8–81.3°C). Variety had a significant (P < 0.001) effect on all the attributes of sweet potato flour. Pretreatment did not significantly (P > 0.05) affect moisture, fat and lightness (L*). Drying method did not significantly (P > 0.05) affect fiber and L*. The interactive effect of variety, pretreatment and drying method had a significant (P < 0.001) effect on all the attributes except fat and fiber. Total sugar correlated significantly (P < 0.01) with water solubility (r = 0.88) of the flour samples. Variety was a dominant factor influencing attributes of sweet potato flour and so should be targeted at specific end uses.
Risk‐Free Rates and Variance Futures Prices
Authors: Rompolis Leonidas S. 
Published: December 2015

AbstractThis paper investigates the relation between risk‐free rates and ex‐ante market volatility. It derives a theoretical model implying a negative linear relation between risk‐free rates and variance futures prices. The latter are employed as a direct market‐based ex‐ante estimate of risk‐neutral volatility. Empirical analysis, conducted using LIBOR and variance futures prices written on the S&P 500 index, indicates that the predictions of the model are supported by the data. The paper also provides evidence that, first, this negative relation varies smoothly over time following business cycles, and, second, the variance risk premium is a significant component of this documented relation. © 2015 Wiley Periodicals, Inc. Jrl Fut Mark 36:943–967, 2016
Geochemical features of the black shales from the Wuyu Basin, southern Tibet: implications for palaeoenvironment and palaeoclimate
Authors: Wang Zhongwei , Fu Xiugen , Feng Xinglei , Song Chunyan , Wang Dong , Chen Wenbin , Zeng Shengqiang 
Published: December 2015

AbstractThe Mangxiang Formation black shales are the most important hydrocarbon source rocks in the Wuyu Basin. Trace and rare earth element (REEs) of the black shales from the Wuyu Basin were studied in order to understand their depositional environments and palaeoclimate. Thirty one black shale samples from the Wuyu Basin were analysed by inductively coupled plasma–mass spectrometry and X‐ray fluorescence. The black shales are characterized by moderate SiO2 (52.55–58.73%) contents and medium K2O/Na2O (2.21–4.83) ratio values but relatively high MgO + Fe2O3 (5.8–6.91%) and Al2O3 (15.1–17.5%) contents. The Chemical Weathering Index of Alternation (CIA) ranges from 57 to 70, together with medium Th/U (2.66–4.97) ratio values, reflecting a weak to moderate degree of chemical weathering of the source area. The palaeoredox condition of black shale was slightly oxic (or dysoxic) during black shale deposition as evidenced by slightly Ce anomalies (0.92–0.99) and Mn enrichment (EF = 1.6). The moderate palaeosalinity values (9.32‰–17.75‰), together with medium B/Ga (3.90–5.57) ratio values, indicate a brackish water environment. The palaeoclimate index ∑(Fe + Mn + Cr + Ni + V + Co)/∑(Ca + Mg + Sr + Ba + K + Na) ranges from 0.28 to 0.50 and low Sr/Ba (0.15–1.22) ratio values, indicating a semiarid to semimoist climatic condition during the sedimentation of the black shale. The high ω(La)N/ω(Yb)N ratio values (1.02–1.09) indicate a fast sedimentary rate during black shale deposition. In this study, a preservation model of the Mangxiang Formation black shale was established. The model indicates that excellent preservation may be the major controlling factor for the accumulation of organic matter. Copyright © 2015 John Wiley & Sons, Ltd.
Disrupted subject‐specific gray matter network properties and cognitive dysfunction in type 1 diabetes patients with and without proliferative retinopathy
Authors: van Duinkerken Eelco , Ijzerman Richard G. , Klein Martin , Moll Annette C. , Snoek Frank J. , Scheltens Philip , Pouwels Petra J.W. , Barkhof Frederik , Diamant Michaela , Tijms Betty M. 
Published: December 2015

AbstractIntroductionType 1 diabetes mellitus (T1DM) patients, especially with concomitant microvascular disease, such as proliferative retinopathy, have an increased risk of cognitive deficits. Local cortical gray matter volume reductions only partially explain these cognitive dysfunctions, possibly because volume reductions do not take into account the complex connectivity structure of the brain. This study aimed to identify gray matter network alterations in relation to cognition in T1DM. Methods: We investigated if subject‐specific structural gray matter network properties, constructed from T1‐weighted MRI scans, were different between T1DM patients with (n = 51) and without (n = 53) proliferative retinopathy versus controls (n = 49), and were associated to cognitive decrements and fractional anisotropy, as measured by voxel‐based TBSS. Global normalized and local (45 bilateral anatomical regions) clustering coefficient and path length were assessed. These network properties measure how the organization of connections in a network differs from that of randomly connected networks. Results: Global gray matter network topology was more randomly organized in both T1DM patient groups versus controls, with the largest effects seen in patients with proliferative retinopathy. Lower local path length values were widely distributed throughout the brain. Lower local clustering was observed in the middle frontal, postcentral, and occipital areas. Complex network topology explained up to 20% of the variance of cognitive decrements, beyond other predictors. Exploratory analyses showed that lower fractional anisotropy was associated with a more random gray matter network organization. Conclusion: T1DM and proliferative retinopathy affect cortical network organization that may consequently contribute to clinically relevant changes in cognitive functioning in these patients. Hum Brain Mapp 37:1194–1208, 2016. © 2015 Wiley Periodicals, Inc.
Bilateral inferior alveolar nerve reconstruction with a vascularized sural nerve graft included in a free fibular osteocutaneous flap after segmental mandibulectomy
Authors: Tanaka Kentaro , Okazaki Mutsumi , Homma Tsutomu , Yano Tomoyuki , Mori Hiroki 
Published: December 2015

ABSTRACTBackgroundSegmental mandibulectomy with bilateral inferior alveolar nerve (IAN) resection results in complete sensory loss in the lower lip and chin. The purpose of this study was for us to report on a bilateral IAN reconstruction with a vascularized nerve graft after chemoradiotherapy during cancer ablation.MethodsThe mandible was reconstructed with a fibular osteocutaneous flap that included the sural nerve. The proximal ends of the right and left IAN were sutured to the proximal and distal ends of the sural nerve in an end‐to‐end manner. The 2 distal ends of the mental nerves were sutured to the sural nerve in an end‐to‐side manner. Sensations were measured using the Semmes–Weinstein monofilaments test.ResultsSensory recovery was first noted after 5 months and the quantitative results of the Semmes–Weinstein test 45 months after surgery were 2.83 to 4.08.ConclusionOne‐stage nerve reconstruction may be indicated for bilateral IAN resection. A vascularized nerve graft is effective especially in a perioperative radiotherapy case. © 2015 Wiley Periodicals, Inc. Head Neck 38: E111–E114, 2016
Predictors of stage at presentation and outcomes of head and neck cancers in a university hospital setting
Authors: Osazuwa–Peters Nosayaba , Christopher Kara M. , Hussaini Adnan S. , Behera Anit , Walker Ronald J. , Varvares Mark A. 
Published: December 2015

ABSTRACTBackgroundTo increase early detection of head and neck cancers, it is important that disparities associated with access to care are addressed.MethodsA total of 351 patients aged 20 to 91 years (58.72 ± 11.70 years) diagnosed with head and neck cancers at a university hospital from 1997 to 2010 were analyzed. Logistic regression assessed the association between clinical stage at presentation and predictors. Cox proportional hazards model assessed the effect of stage at presentation on survival.ResultsBeing African American was associated with increased odds of late stage at presentation (adjusted odds ratio [OR] = 2.16; 95% confidence interval [CI] = 1.01–4.59), and those without health insurance were 10.97 times more likely to present at late stage (95% CI = 1.30–92.49). Unmarried patients were 1.6 times at an increased hazard of death (95% CI = 1.12–2.24).ConclusionDisparities, such as race and health insurance status, are important predictors of stage at presentation of patients with head and neck cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1826–E1832, 2016