bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Evidence-Based Interventions to Improve Cancer Screening in the National Breast and Cervical Cancer Early Detection Program
Authors: DeGroff Amy , Carter Aundrea , Kenney Kristy , Myles Zachary , Melillo Stephanie , Royalty Janet , Rice Ketra , Gressard Lindsay , Miller Jacqueline W. 
Published: December 2015

Context:
The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) provides cancer screening to low-income, un-, and underinsured women through more than 11 000 primary care clinics. The program is well-positioned to work with health systems to implement evidence-based interventions (EBIs) to increase screening among all women.

Objective:
To collect baseline data on EBI use, evaluation of EBIs, and related training needs among NBCCEDP grantees.

Design:
The Centers for Disease Control and Prevention conducted a Web-based survey in late 2013 among NBCCEDP grantees for the period July 2012 to June 2013. This was the first systematic assessment of EBIs among NBCCEDP grantees.

Setting:
The Centers for Disease Control and Prevention's NBCCEDP.

Participants:
Primarily program directors/coordinators for all 67 NBCCEDP grantees.

Main Outcome Measures:
Data captured were used to assess implementation of 5 EBIs, their evaluation, and related training needs. Frequencies and proportions were determined. Cluster analysis identified grantees with similar patterns of EBI use for NBCCEDP clients and providers.

Results:
On average, 4.1 of 5 EBIs were implemented per grantee for NBCCEDP clients and providers. Four clusters were identified including “high overall EBI users,” “high provider EBI users,” “high EBI users with no provider assessment and feedback,” and “high client EBI users.” Only 1.8 EBIs were implemented, on average, with non-NBCCEDP clients and providers. Fewer than half (n = 32, 47.8%) of grantees conducted process or outcome evaluation of 1 or more EBIs. Overall, 47.6% of grantees reported high or medium training needs for client-oriented EBIs and 54.3% for provider-oriented EBIs.

Conclusions:
The NBCCEDP grantees are implementing EBIs extensively with clients and providers. Increased EBI use among non-NBCCEDP clients/providers is needed to extend the NBCCEDP's reach and impact. Grantee training and technical assistance is necessary across EBIs. In addition, grantees' use of process and outcome evaluation of EBI implementation must be increased to inform effective program implementation.
Evidence of adoption, monozygotic twinning, and low inbreeding rates in a large genetic pedigree of polar bears
Authors: Malenfant René M. , Coltman David W. , Richardson Evan S. , Lunn Nicholas J. , Stirling Ian , Adamowicz Elizabeth , Davis Corey S. 
Published: December 2015

AbstractMultigenerational pedigrees have been developed for free-ranging populations of many species, are frequently used to describe mating systems, and are used in studies of quantitative genetics. Here, we document the development of a 4449-individual pedigree for the Western Hudson Bay subpopulation of polar bears(Ursus maritimus), created from relationships inferred from field and genetic data collected over six generations of bears sampled between 1966 and 2011. Microsatellite genotypes for 22–25 loci were obtained for 2945 individuals, and parentage analysis was performed using the program FRANz, including additional offspring–dam associations known only from capture data. Parentage assignments for a subset of 859 individuals were confirmed using an independent high-density set of single nucleotide polymorphisms. To account for unsampled males in our population, we performed half-sib–full-sib analysis to reconstruct males using the program COLONY, resulting in a final pedigree containing 2957 assigned maternities and 1861 assigned paternities with only one observed case of inbreeding between close relatives. During genotyping, we identified two independently captured two-year-old males with identical genotypes at all 25 loci, showing—for the first time—a case of monozygotic twinning among polar bears. In addition, we documented six new cases of cub adoption, which we attribute to cub misidentification or misdirected maternal care by a female bereaved of her young. Importantly, none of these adoptions could be attributed to reduced female vigilance caused by immobilization to facilitate scientific handling, as has previously been suggested.
Mating-induced Male Death and Pheromone Toxin-regulated Androstasis
Authors: Shi Cheng , Runnels Alexi M. , Murphy Coleen T. 
Published: December 2015

AbstractHow mating affects male lifespan is poorly understood. Using single worm lifespan assays, we discovered that males live significantly shorter after mating in both androdioecious (male and hermaphroditic) and gonochoristic (male and female)Caenorhabditis. Germline-dependent shrinking, glycogen loss, and ectopic expression of vitellogenins contribute to male post-mating lifespan reduction, which is conserved between the sexes. In addition to mating-induced lifespan decrease, worms are subject to killing by male pheromone-dependent toxicity.C. elegansmales are the most sensitive, whereasC. remaneiare immune, suggesting that males in androdioecious and gonochoristic species utilize male pheromone differently as a toxin or a chemical messenger. Our study reveals two mechanisms involved in male lifespan regulation: germline-dependent shrinking and death is the result of an unavoidable cost of reproduction and is evolutionarily conserved, whereas male pheromone-mediated killing provides a novel mechanism to cull the male population and ensure a return to the self-reproduction mode in androdioecious species. Our work highlights the importance of understanding the shared vs. sex- and species-specific mechanisms that regulate lifespan.
Simple penalties on maximum likelihood estimates of genetic parameters to reduce sampling variation
Authors: Meyer Karin 
Published: December 2015

ABSTRACTMultivariate estimates of genetic parameters are subject to substantial sampling variation, especially for smaller data sets and more than a few traits. A simple modification of standard, maximum likelihood procedures for multivariate analyses to estimate genetic covariances is described, which can improve estimates by substantially reducing their sampling variances. This is achieved maximizing the likelihood subject to a penalty. Borrowing from Bayesian principles, we propose a mild, default penalty – derived assuming a Beta distribution of scale-free functions of the covariance components to be estimated – rather than laboriously attempting to determine the stringency of penalization from the data. An extensive simulation study is presented demonstrating that such penalties can yield very worthwhile reductions in loss, i.e. the difference from population values, for a wide range of scenarios and without distorting estimates of phenotypic covariances. Moreover, mild default penalties tend not to increase loss in difficult cases and, on average, achieve reductions in loss of similar magnitude than computationally demanding schemes to optimize the degree of penalization. Pertinent details required for the adaptation of standard algorithms to locate the maximum of the likelihood function are outlined.
Unsupervised data-driven stratification of mentalizing heterogeneity in autism
Authors: Lombardo Michael V. , Lai Meng-Chuan , Auyeung Bonnie , Holt Rosemary J. , Allison Carrie , Smith Paula , Chakrabarti Bhismadev , Ruigrok Amber N. V. , Suckling John , Bullmore Edward T. ,   MRC AIMS Consortium, Ecker Christine , Craig Michael C. , Murphy Declan G. M. , Happé Francesca , Baron-Cohen Simon 
Published: December 2015

AbstractIndividuals affected by autism spectrum conditions (ASC) are considerably heterogeneous. Novel approaches are needed to parse this heterogeneity to enhance precision in clinical and translational research. Applying a clustering approach taken from genomics and systems biology on two large independent cognitive datasets of adults with and without ASC (n=715; n=251), we find replicable evidence for 5 discrete ASC subgroups that are highly differentiated in item-level performance on an explicit mentalizing task tapping ability to read complex emotion and mental states from the eye region of the face (Reading the Mind in the Eyes Test; RMET). Three subgroups comprising 42-65% of ASC adults show evidence for large impairments (Cohen’s d = −1.03 to −11.21), while other subgroups are effectively unimpaired. These findings delineate robust natural subdivisions within the ASC population that may allow for more individualized inferences and accelerate research towards precision medicine goals.
Pipecolic Acid Orchestrates Plant Systemic Acquired Resistance and Defense Priming via Salicylic Acid-Dependent and -Independent Pathways
Authors: Bernsdorff Friederike , Döring Anne-Christin , Gruner Katrin , Schuck Stefan , Bräutigam Andrea , Zeier Jürgen 
Published: December 2015

AbstractWe investigated the relationships of the two immune-regulatory plant metabolites, salicylic acid (SA) and pipecolic acid (Pip), in the establishment of plant systemic acquired resistance (SAR), SAR-associated defense priming, and basal immunity. Using SA-deficient sid2, Pip-deficient ald1, and sid2 ald1 plants deficient in both SA and Pip, we show that SA and Pip act both independently from each other and synergistically in Arabidopsis thaliana basal immunity to Pseudomonas syringae. Transcriptome analyses reveal that SAR establishment in Arabidopsis is characterized by a strong transcriptional response systemically induced in the foliage that prepares plants for future pathogen attack by preactivating multiple stages of defense signaling and that SA accumulation upon SAR activation leads to the downregulation of photosynthesis and attenuated jasmonate responses systemically within the plant. Whereas systemic Pip elevations are indispensable for SAR and necessary for virtually the whole transcriptional SAR response, a moderate but significant SA-independent component of SAR activation and SAR gene expression is revealed. During SAR, Pip orchestrates SA-dependent and SA-independent priming of pathogen responses in a FLAVIN-DEPENDENT-MONOOXYGENASE1 (FMO1)-dependent manner. We conclude that a Pip/FMO1 signaling module acts as an indispensable switch for the activation of SAR and associated defense priming events and that SA amplifies Pip-triggered responses to different degrees in the distal tissue of SAR-activated plants.
Alliance portfolio formation and configuration by small and medium ICT firms
Authors: Golonka Monika , Latusek Dominika 
Published: December 2015

Purpose– The purpose of this paper is to explore the forming and configuring of interfirm cooperation in small and medium enterprises (SMEs) characterized by different rates of growth.Design/methodology/approach– The study applies a qualitative approach. A multi-site case study was conducted in 26 Polish ICT firms.Findings– The research indicates that SMEs manage alliances ad hoc and are characterized by a constantly emerging portfolio of partners. The results also indicate that “stable-growth” and “hyper-growth” firms adopt different approaches to managing alliances and they are characterized by different attitude of top managers towards uncertainty.Practical implications– The results suggest that the managers’ attitude affects the formation and management of alliance portfolio in SMEs. The authors further highlight the importance of managerial agency within the firms and indicate that managers can actively shape the alliance portfolio of their firms.Originality/value– The paper theoretically contributes to alliance portfolio literature through the adoption of both managerial and structural perspectives. More precisely, this study provides the factors related to managers that might affect a firm’s alliance portfolio configuration. All of these factors relate to managers’ approach to uncertainty. Furthermore, this study extends the previous research through focusing on SMEs.
Path optimization of CNC PCB drilling using hybrid Taguchi genetic algorithm
Authors: Al-Janan Dony Hidayat , Liu Tung-Kuan 
Published: December 2015

Purpose
– In this study, the hybrid Taguchi genetic algorithm (HTGA) was used to optimize the computer numerical control-printed circuit boards drilling path. The optimization was performed by searching for the shortest route for the drilling path. The number of feasible solutions is exponentially related to the number of hole positions. The paper aims to discuss these issues.

Design/methodology/approach
– Therefore, a traveling cutting tool problem (TCP), which is similar to the traveling salesman problem, was used to evaluate the drilling path; this evaluation is considered an NP-hard problem. In this paper, an improved genetic algorithm embedded in the Taguchi method and a neighbor search method are proposed for improving the solution quality. The classical TCP problems proposed by Lim et al. (2014) were used for validating the performance of the proposed algorithm.

Findings
– Results showed that the proposed algorithm outperforms a previous study in robustness and convergence speed.

Originality/value
– The HTGA has not been used for optimizing the drilling path. This study shows that the HTGA can be applied to complex problems.
A TOPSIS extension framework for re-conceptualizing sustainability measurement
Authors: Afful-Dadzie Anthony , Afful-Dadzie Eric , Turkson Charles 
Published: December 2015

Purpose
– The purpose of this paper is to propose a sustainability measurement and scoring system for assessing the efforts of organizations at meeting sustainability targets. Using technique for order preference by similarity to ideal solution (TOPSIS) as the basic framework, the proposed method incorporates all three sustainability dimensions – economic, environmental and social – to establish a threshold below which an organization is considered to have failed a sustainability test. In Addition, an introduction of a time-independent threshold enables a clearer comparison of performance of organizations over time. The proposed method includes plots for visualizing the sustainability performance of organizations under review.

Design/methodology/approach
– The proposed method first assigns target values to a hypothetical organization. TOPSIS is then used to generate composite scores in which the score of the hypothetical organization is set as the threshold below which organizations are deemed to have failed a sustainability test. Using the square of the closeness coefficient of TOPSIS, the final composite score is decomposed into three components to reflect the contribution of the three dimensions of sustainability to serve as a guide to determining which dimension to focus on for improvement. A relative comparison score is then proposed to track the performance of organizations over time.

Findings
– The proposed method with its ability to set a threshold is able to determine organizations that have passed a sustainability test from those that have failed. The tracking of organizational performance over time also serves to highlight progress being made by organizations to meet an agreed sustainability target. Results from the application of the proposed method for evaluating sustainability of banks under the three dimensions of sustainability highlight its practical applicability. The proposed method can also be applied to a wide range of comparison problems including make-or-by decisions and award selection.

Practical implications
– As most industries and organizations become conscious of the pressure to adopt sustainable practices, the proposed measuring system would help identify those that are meeting sustainability targets as well as to track their progress over time.

Originality/value
– Most sustainability measurement indicators rarely have thresholds to determine whether an organization has met or failed to meet a sustainability test other than ranking them from top to bottom. The proposed method provides a threshold as well as a procedure for tracking the sustainability performance of organizations over time.
Mimosa pudica L., a High‐Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals
Authors: Muhammad Gulzar , Hussain Muhammad Ajaz , Jantan Ibrahim , Bukhari Syed Nasir Abbas 
Published: December 2015

AbstractMimosa pudica Linn. (Family: Mimosaceae) is used as an ornamental plant due to its thigmonastic and nyctinastic movements. M. pudica is also used to avoid or cure several disorders like cancer, diabetes, hepatitis, obesity, and urinary infections. M. pudica is famous for its anticancer alkaloid, mimosine, along with several valuable secondary metabolites like tannins, steroids, flavonoids, triterpenes, and glycosylflavones. A wide array of pharmacological properties like antioxidant, antibacterial, antifungal, anti‐inflammatory, hepatoprotective, antinociceptive, anticonvulsant, antidepressant, antidiarrheal, hypolipidemic activities, diuretic, antiparasitic, antimalarial, and hypoglycemic have been attributed to different parts of M. pudica. Glucuronoxylan polysaccharide extruded from seeds of M. pudica is used for drug release formulations due to its high swelling index. This review covers a thorough examination of functional bioactives as well as pharmacological and phytomedicinal attributes of the plant with the purpose of exploring its pharmaceutical and nutraceutical potentials.
Change in the EU Dairy Sector Post Quota: More Milk, More Exports and a Changing Farmer Profile
Authors: Giles John 
Published: December 2015

SummaryRemoval of EU dairy quotas in April 2015 coincided with a downturn in world market demand along with continued increases in production in key producing areas, resulting in a slump in world market prices and testing times for world dairy farmers which may continue for some time. However, the prospects for many parts of the EU dairy sector remain fundamentally good. The majority of growth will come from the nine largest producers, excluding Spain and Italy. However, with low projected demand growth in Europe, processors will need to capture shares of emerging markets in Africa, the Middle East and Asia. In the next decade EU dairy processing capacity will shift to the better production regions. For high volume products such as liquid milk this will mean areas strategically sited close to consumer markets. Dairy support services such as veterinary, genetic and machinery suppliers will also focus on these high density milk production areas. Farmers outside these areas will find it harder to compete and remain viable. Increased competition between EU milk producers will increase demand for cost‐reducing technologies to enhance their competitiveness. EU dairy farmers will need to move progressively from being passive survivors to proactive entrepreneurial leaders.
Nucleophosmin mutation in de‐novo acute myeloid leukemia
Authors: Rastogi Pulkit , Naseem Shano , Varma Neelam , Varma Subhash 
Published: December 2015

AbstractObjectiveAcute myeloid leukemia (AML) with mutated nucleophosmin gene (NPM1) has distinctive clinical, hematological and molecular features, and is included as a provisional entity in 2008 World Health Organization classification. In this study, we analyzed the frequency and features of AML with mutated NPM1 in Indian patients.MethodsOne‐hundred consecutive patients of de‐novo AML were evaluated for NPM1 mutation and their features were compared with unmutated NPM1 patients.ResultsAML with mutated NPM1 was seen in 21% cases. There was female preponderance with median age of 51 years. Distinguishing Features in mutated group were less bleeding manifestations and bone pains; more lymphadenopathy; higher median total leukocyte and platelet count; less frequency of pancytopenia and more preserved megakaryocytes. Morphologically, cup‐shaped nuclei in peripheral blood blasts correlated with NPM1 mutation (p <0.01), but not bone marrow blasts. Among the French–American–British subtypes, NPM1 mutation was seen in M1, M4 and M2 subtypes but not in M0 and M3. Immunophenotypically, there was statistically significant negativity for CD34, strong association with monocytic markers (especially CD11c), CD123 was seen at higher frequency and higher mean fluorescence intensity (MFI) values for CD33 were observed in mutated cases.ConclusionsImportant findings in this study that have not been highlighted in detail in previous studies in NPM1‐mutated cases include less bleeding manifestations and bone pains, lower frequency of pancytopenia and more preserved magakaryocytes, higher CD123 expression and higher MFI values for CD33. Presence of blasts with cup‐shaped nuclei correlated with NPM1 mutation.
Frontline treatment of epithelial ovarian cancer
Authors: GOH Jeffrey , MOHAN G Raj , LADWA Rahul , ANANDA Sumitra , COHEN Paul A , BARON‐HAY Sally 
Published: December 2015

AbstractThis is a contemporaneous review of the frontline treatment of epithelial ovarian cancer (EOC), specifically on the importance of optimal surgical cytoreductive surgery, the pivotal role of platinum‐based adjuvant chemotherapy (which encompasses intraperitoneal and dose‐dense regimens) and the emergence of neo‐adjuvant chemotherapy. Additionally, the benefit of concurrent and maintenance bevacizumab in the suboptimally debullked stage III and stage IV EOC setting is also reviewed. The article also discusses the increasing importance of prognostic and predictive molecular biomarkers in the future management of EOC.
Comparison of Two Parathyroid Hormone Assays in Hemodialysis Patients
Authors: Donati Gabriele , Cianciolo Giuseppe , Capelli Irene , Baraldi Olga , Gambaretto Camilla , Demelas Valentina , Marchetti Antonio , La Manna Gaetano 
Published: December 2015

AbstractParathyroid hormone (PTH) determination is essential for the diagnosis of renal osteodystrophy, but differences between the laboratory assays can lead to different therapies. This study compared the new Tosoh ST AIA‐Pack Intact PTH assay (Tosoh Bioscience, San Francisco, CA, USA) with the Elecsys Intact PTH Roche assay (Roche Diagnostics GmbH, Mannheim, Germany), currently considered the gold standard. Nineteen chronic stable hemodialysis patients were enrolled to check PTH levels with the two assays. Median age was 71 years (range 26–84), M/F = 10/9. Blood samples were taken before the start of the same midweek dialysis session. Two blood vacuettes were collected and immediately transported to the central laboratory. The median PTH value was 268 (range 35–901 pg/dL) with the AIA‐Pack versus 184 (range 39–552 pg/dL) with Elecsys. The Wilcoxon test showed a significant difference between the two methods (P < 0.0001). AIA‐Pack showed a delta value of +38% in comparison with Elecsys and a median bias of 27.4%. For PTH values <150 pg/dL, nine patients were detected with AIA‐Pack (47.4%) versus nine patients detected with Elecsys (47.4%). For PTH values between 150 and 300 pg/dL, six patients were detected with AIA‐Pack (31.6%) versus four patients with Elecsys (21.0%). For PTH values >300 pg/dL four patients were detected with AIA‐Pack (21.0%) versus six patients with Elecsys (31.6%). The two assays showed no differences for each of the three PTH ranges considered. The two PTH assays tested are different and the attending physician should be aware of the differences when patients change their dialysis facility.
Language Use and Coalition Formation in Multiparty Negotiations
Authors: Sagi Eyal , Diermeier Daniel 
Published: December 2015

AbstractThe alignment of bargaining positions is crucial to a successful negotiation. Prior research has shown that similarity in language use is indicative of the conceptual alignment of interlocutors. We use latent semantic analysis to explore how the similarity of language use between negotiating parties develops over the course of a three‐party negotiation. Results show that parties that reach an agreement show a gradual increase in language similarity over the course of the negotiation. Furthermore, reaching the most financially efficient outcome is dependent on similarity in language use between the parties that have the most to gain from such an outcome.