bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of erlotinib as first-line maintenance therapy in patients with locally advanced or metastatic nonsmall cell lung cancer who have not experienced disease progression or unacceptable toxicity during chemotherapy
Authors: Rajappa Senthil , Doval Dinesh Chandra , Biswas Jaydip , Patil Shekar , Somani Naresh , Srinivasan Sankar , Bondarde Shailesh , Palwe Nitin S. , Swarup Binay 
Published: March 2017

Abstract
Bacground: First-line maintenance with erlotinib in nonsmall cell lung cancer (NSCLC) patients without progression after four cycles of chemotherapy was well tolerated and significantly prolonged progression-free survival (PFS) compared with placebo. Aim and Design: This open-label, single arm, Phase IV, interventional study was designed to evaluate erlotinib as first-line maintenance after chemotherapy in Indian NSCLC patients. Primary efficacy objective was to evaluate PFS rate (PFSR) at week 52 and secondary objectives were determination of PFS, overall survival (OS), overall response rate (ORR), disease control rate, and safety. Subjects and Methods: Patients were treated with erlotinib until disease progression/death/unacceptable toxicity or end of study. Patients with disease progression underwent scheduled clinical assessments every 12 weeks thereafter. Kaplan–Meier estimates were used to evaluate PFSR, PFS, and OS. The ORR was summarized using number and percentage along with two-sided 95% Clopper–Pearson confidence interval. The incidence of adverse events (AEs) and serious AEs (SAEs) was tabulated according to severity, outcome, and relationship to erlotinib. Results: Of the 51 enrolled patients, 47 patients completed the study (2: Continuing treatment, 41: Disease progression, and 4: Death) and four patients discontinued treatment (3: Lost to follow-up; 1: Withdrew consent). PFSR was 22.5% at 12 months, median PFS 99 days (14.14 weeks), and median OS was 671 days (22 months). The probability of OS was 74.5% at 14 months. The ORR was 25.5%, and disease control rate was 55.3%. AEs were reported in 62.7% and SAE in 7.8% of patients. Common AEs were diarrhea and rash. Conclusions: Erlotinib was well tolerated by Indian patients in first-line maintenance setting and resulted in median PFS of 14 weeks and median OS of 22 months better than previously reported and with no new safety concerns in this population.
On Dirichlet Spaces With a Class of Superharmonic Weights
Authors: Bao Guanlong , Göğüş Nihat Gokhan , Pouliasis Stamatis 
Published: March 2017

AbstractIn this paper, we investigate Dirichlet spaces with superharmonic weights induced by positive Borel measures μ on the open unit disk. We establish the Alexander-Taylor-Ullman inequality for spaces and we characterize the cases where equality occurs. We define a class of weighted Hardy spaces via the balayage of the measure μ. We show that is equal to if and only if μ is a Carleson measure for . As an application, we obtain the reproducing kernel of when μ is an infinite sum of point-mass measures. We consider the boundary behavior and innerouter factorization of functions in . We also characterize the boundedness and compactness of composition operators on .
Opinar de política en la prensa escrita española. Análisis del período Elecciones Generales en España, 2015
Authors: Blasco-Duatis Marc , Fernández García Nuria , Cunha Isabel 
Published: March 2017

El presente artículo es parte de los resultados obtenidos por el autor en su investigación de doctorado titulada ‘Opinar de política, mediatizar democracias. El storytelling de la opinión política en los medios de comunicación españoles y los nuevos escenarios transmediáticos para la acción social’. Metodología. Se trata de un abordaje original en lo que concierne a la temática de las Elecciones Generales españolas de 2015 que, en base al análisis cuantitativo y con metodologías de análisis de contenido de los artículos de opinión, permite evaluar la construcción de la opinión pública en la prensa escrita por parte de las cinco cabeceras de información generalista con mayor tirada estatal. Resultados y conclusiones. Con éste análisis se consigue mapear la representación del pensamiento sobre política expresada por los opinantes. El análisis de esta opinión publicada sobre política ha permitido alcanzar una estampa sobre aquellos actores que han participado como opinantes, los temas que se han tratado, la forma y contexto como se han presentado y, en suma, el escenario propuesto por la opinión en prensa escrita en el debate público sobre el contexto político electoral.
Ludwig’s Angina: Emergency Treatment
Authors: Kamala, KA , S Sankethguddad , SG Sujith 
Published: March 2017

ABSTRACT
Ludwig’s angina is a form of severe diffuse cellulitis that presents an acute onset and spreads rapidly, bilaterally affecting the submandibular, sublingual, and submental spaces resulting in a state of emergency. Early diagnosis and immediate treatment planning could be a life-saving procedure. Here, we report a case of Ludwig’s angina successfully treated by surgical decompression under antibiotic coverage.

How to cite this article
Kamala KA, Sankethguddad S, Sujith SG. Ludwig’s Angina: Emergency Treatment. J Health Sci Res 2017;8(1):46-48.
O sistema de conjunção em textos acadêmicos: os mecanismos de sequenciamento e de explicação
Authors: Vian Jr. Orlando , Mendes Wellington Vieira 
Published: March 2017

Dentre os seis sistemas discursivos propostos por Martin e Rose (2007 [2003]), o sistema de conjunção possibilita analisar as relações entre os processos de um texto com base em quatro tipos gerais de conjunções: adição, comparação, tempo e consequência. A partir de um recorte do corpusdos textos que compõem o SAL – Systemics Across Languages,nosso objetivo neste texto é observar como se caracterizam as relações conjuntivas em textos acadêmicos, com foco nas ocorrências léxico-gramaticais de sequenciamento e de explicação, como forma de explorar o texto acadêmico em quatro realizações distintas: um artigo de graduação, um trabalho de conclusão de curso de graduação, uma dissertação de mestrado e uma tese de doutorado. O objetivo primordial é explorar como os mecanismos estão organizados nos quatro níveis acadêmicos e o que revelam sobre a produção textual, fornecendo subsídios para outros estudos sobre textos e gêneros acadêmicos que, por sua vez, podem embasar propostas de letramento acadêmico, principalmente no que diz respeito à formação do pesquisador e sua produção textual e o ensino da produção escrita.
(Re)Configurações identitárias do professor coordenador de inglês sob a luz da avaliatividade
Authors: Magalhães Célia Elisa Alves de , Nóbrega Adriana Nogueira Accioly 
Published: March 2017

Desenvolvido na área da Linguística Aplicada das Profissões (SARANGI, 2012), este trabalho investiga a construção identitária do professor coordenador de inglês, com base em elementos avaliativos. A arquitetura teórica fundamenta-se no conceito de identidade pelo viés de teorias socioconstrucionistas (BUCHOLTZ; HALL, 2003, 2005) em interface com os pressupostos do Sistema de Avaliatividade (MARTIN; WHITE, 2005; VIAN JR., 2009, 2012). Os dados da pesquisa foram gerados por meio de entrevista de pesquisa qualitativa e os resultados sugerem que a (re)configuração identitária do professor coordenador, neste contexto, perpassa pelo uso de recursos semânticos avaliativos de afeto, julgamento e apreciação.
Contribuições da linguística sistêmico-funcional (lsf) para o entendimento do texto literário em contexto de formação de tradutores
Authors: Rodrigues-Júnior Adail Sebastião 
Published: March 2017

Este capítulo parte da definição de texto como artefato (cultural) para discutir formas de abordagem do texto literário em contexto de tradução. Depreende-se dessa discussão que as relações entre o texto original e sua retextualização para uma línguaalvo, no par linguístico inglês-português, não são diretas, mas, ao contrário, saturadas de ideologias. As perguntas que orientaram a escrita deste capítulo foram: O que deve ser levado em conta no texto literário no momento de sua tradução? Como traduzi-lo de modo a apreender todas as relações que a trama faz com a realidade (ficcional) de seus personagens, em contextos sociais às vezes tão adversos, quando comparados com o contexto da cultura receptora? As discussões conduzem para o reconhecimento da problemática instaurada no ato de traduzir, sobretudo quando se utiliza o arcabouço teóricometodológico da Avaliatividade (Appraisal) para o entendimento dessa problemática.
FTIR-SPECTROSCOPIC INVESTIGATION OF SODIUM TUNGSTATE AND SODIUM MOLYBDATE SOLUTIONS IN WIDE RANGE OF рH
Authors: Matveichuk Yulya V. 
Published: March 2017

For citation:Matveichuk Yu.V. FTIR-spectroscopic investigation of sodium tungstate and sodium molybdate solutions in wide range of рH. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 1. P. 56-63. A FTIR spectroscopic study of aqueous solutions of sodium tungstate and molybdate (solution concentration was 0.1 mol/l) over a wide pH range (factor (level) of acidity Z, Z = C (H+)/C (WO42-) or Z = C (H+)/C(MoO42-)) was carried out. In solutions of sodium tungstate complex frequency band at 885-865 cm-1 correspoding to the stretching vibrations ν(W-O-W) was fixed. The frequency bands of 1720-1700 cm-1, 990, 985 and 1025 cm-1 corresponding to bending vibrations δ(W-OH) were fixed that indicates a significant change in composition of the solution as a result of hydrolytic and polycondensation processes. The sodium molybdate solution has not bands corresponding to the stretching vibrations v(Mo-O-Mo). Only the characteristic bands of the deformation vibrations δ(Mo-OH) were recorded. The low intensity complex band in the area of 885-865 cm-1 corresponding to the stretching vibrations ν(W-O-W) even for freshly prepared 0.1 mol/l sodium tungstate solution was appeared as well as the band at 1720-1700 cm-1 attributed to deformation vibrations δ(W-OH) that indicates a fast change in the solution composition. For solutions of sodium molybdate bands of stretching vibrations v(Mo-O-Mo) are fixed at a pH less than 6 after standing for several days. With Hydra/Medusa program diagrams of distribution of molybdate and tungsten particle depending on the pH were calculated. In relatively dilute solutions, the diagrams received with Hydra/Medusa program showed the only protonated (monomeric) form of molybdate ions, where as in the sodium tungstate solution until pH of 9 W6O216- and HW6O215- particles exist that agrees with the results of IR spectroscopy. The results of IR spectroscopy and modeling with Hydra/Medusa program will be used to support the pH operating range for molybdate and tungstate-selective electrodes, since they are an important feature of any analytical ion-selective electrodes. For tungstate-selective electrode it is necessary to maintain the pH less than 9, for molybdate-selective electrode - less than 8 (with dilute ammonia). Considering the changes in the composition of sodium molybdate and tungstate solutions, for the design of molybdate and tungstate-selective electrodes the freshly prepared solutions have to be only used, rather than stored for more than two days.
PLANT GROWTH REGULATORS BASED ON CYCLIC KETALS AND THEIR DERIVATIVES
Authors: Raskil’dina Gul’nara Z. , Borisova Yulianna G. , Mikhaiylova Natalia N. , Zlotskiy Semyon S. , Mryasova Louise M. , Kuznetsov Vyacheslav M. 
Published: March 2017

For citation:Raskil’dinaG.Z., BorisovaY.G., MikhailovaN.N., MryasovaL.M., KuznetsovV.M., ZlotskiyS.S. Plant growth regulators based on cyclic ketals and their derivatives. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 1. P. 95-101.Low toxicity of polyfunctional 1,3-dioxocyclicalkanes to soil bacteria allows to consider the compounds of this class as perspective herbicides. In this regard, we studied the herbicidal activity of a series of substituted cyclic ketals, their derivatives and alkenylmalonates. On the basis of commercially available triols the corresponding cyclic ketals were obtained with a yield more than 90%. O-alkylation of alcohol according to the methods led to the corresponding ethers and esters. The glycerol monoethers were obtained quantitatively by acid hydrolysis of ketals. Growth-regulatory activity of the synthesized compounds was determined in vitro on wheat and pea seedlings according to a known procedure (aromatic solvent - nefras A 150/330, surfactant - oxyethylated izononilfenol neonol AF-9-12). Evaluation of herbicidal activity of preparations was carried out in the laboratory. During 3 days length (L, mm) and weight (m, g) seedlings in comparison with the control option was measured. Without herbicide on seedlings the monocotyledonous and dicotyledonous plants are placed in Petri dishes containing water emulsion of active substances with a concentration of 5 mg / l and 10 mg / l for peas and 50 mg / l and 100 mg / l for wheat. As a reference well-known herbicide, Oktapon Extra, was used. The diol with allyloxy-diol group showed the best results towards wheat. This compound successfully inhibits the increase in the length and weight of escape and gives close results to the standard. For peas, ketals and derivatives thereof are effective only in terms of inhibition of the shoot masses. Heterocyclic alcohol and glycols are superior to the standard, and a ketal at a concentration of 10 mg / l practically corresponds to it. Alkenylmalonates were more effective in inhibiting the escape weight wheat than peas. In particular, at a concentration of 100mg / l effectiveness of methallyl derivatives of trans-1,3-dichloropropene coincides to the standard. Physical and chemical characteristics of the compounds were proved by NMR and mass spectra. Screening results showed that activity of diol with allyloxy group is close to the ideal attitude to wheat. Ketals and their derivatives show the herbicidal activity only at inhibition of the mass escape of peas. Results of alkenylmalonates were better at inhibition of the mass escape of wheat than peas. The obtained results prove prospectivity of producing of herbicidal drugs based on the alkenylmalonates substituted diols and acetals, as a new generation of herbicides.
Trans Fatty Acids Suppress TNF‐α‐Induced Inflammatory Gene Expression in Endothelial (HUVEC) and Hepatocellular Carcinoma (HepG2) Cells
Authors: Da Silva Marine S. , Julien Pierre , Bilodeau Jean‐François , Barbier Olivier , Rudkowska Iwona 
Published: March 2017

AbstractTrans fatty acids (TFA) intake has been linked to cardiovascular diseases and liver diseases; yet the effect of TFA on inflammation remains controversial. Accordingly, the objective of this paper was to determine the in vitro effects of TFA on inflammatory gene expression. Human umbilical vein endothelial cells (HUVEC) and human hepatocellular carcinoma (HepG2) cells were treated for 24 h with either trans‐vaccenic acid (tVA), trans‐palmitoleic acid (tPA) or elaidic acid (EA) at concentrations of 5–150 µM, or with a mixture of tVA and tPA (150/50 µM). All TFA were highly incorporated into cell membranes, as determined by gas chromatography, representing 15–20% of total fatty acids in HUVEC and 3–8% in HepG2 cells. Incorporation of EA, a common industrial TFA, increased the ratio of the stearoyl‐CoA desaturase (SCD‐1), a key enzyme involved in fatty acid metabolism. Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF‐α‐induced gene expression of TNF, VCAM‐1 and SOD2 in HUVEC, as well as TNF and IL‐8 in HepG2 cells. EA also decreased inflammatory gene expression in HUVEC, but not in HepG2 cells. The inhibition of peroxisome proliferator‐activated receptor (PPAR)‐γ did not influence the effects of TFA on gene expression. Overall, physiological and supraphysiological concentrations of TFA, especially tVA and tPA, prevented inflammatory gene expression in vitro. This effect is independent of PPAR‐γ activation and may be due to an alteration of fatty acid metabolism in cell membranes caused by the high incorporation of TFA.
Nutrient biomarker patterns and long‐term risk of dementia in older adults
Authors: Amadieu Camille , Lefèvre‐Arbogast Sophie , Delcourt Cécile , Dartigues Jean‐François , Helmer Catherine , Féart Catherine , Samieri Cécilia 
Published: March 2017

AbstractIntroductionSeveral nutrients may predict dementia risk. We characterized nutrient biomarker patterns, which integrate the complexity of nutrient exposure and biodisponibility associated with long‐term risk of dementia in a large cohort of older persons, the Three‐City study.MethodsWe included 666 nondemented participants with plasma measurements of 22 fat‐soluble nutrients at baseline, who were followed up for 12 years for dementia.ResultsA “deleterious” pattern combining lower blood status in vitamin D, carotenoids, and polyunsaturated fats and higher saturated fats was strongly associated with a higher risk of dementia. Compared with individuals in the first quintile of the pattern score, participants in the highest quintile of score had an approximately fourfold increased risk of dementia (hazard ratio = 4.53 [95% confidence interval 1.99, 10.32], P for trend <.001) in multivariate models.DiscussionA blood pattern reflecting lower status in several nutrients among nondemented individuals appeared strongly associated with the long‐term risk of dementia in this cohort.
Une théorie de Morse pour les systèmes hamiltoniens convexes
Authors: Ekeland Ivar 
Published: March 2017

This paper deals with convex Hamiltonian systems. It is shown that, on any prescribed energy level, either the closed trajectories are infinitely many, or they fulfil a resonance condition. It follows that, generically, there are infinitely many closed trajectories on a prescribed energy level. A dual form of the least action principle, Morse theory, an iteration formula for the index, and Thom’s transversality theorem, are used to obtain these results.

Résumé
On s’intéresse à des systèmes hamiltoniens convexes. On démontre que, sur une surface d’énergie donnée, ou bien les trajectoires fermées sont en nombre infini, ou bien elles vérifient une relation de résonance. On en déduit que génériquement, les trajectoires fermées sont en nombre infini. La démonstration repose sur une forme duale du principe de moindre action, sur la théorie de Morse, sur une formule d’itération pour l’index, et sur le théorème de transversalité de Thom.
A rapid convergence method for a singular perturbation problem
Authors: Rabinowitz Paul H. 
Published: March 2017

The existence of spatially periodic solutions for a singular perturbation of elliptic type is established. A rapid convergence method is used to obtain the result.

Résumé
On démontre l’existence de solutions périodiques par rapport aux variables d’espace pour un problème de perturbation singulière de type elliptique. La démonstration repose sur une méthode de convergence rapide.
Characterizing Articulation in Apraxic Speech Using Real-Time Magnetic Resonance Imaging
Authors: Hagedorn Christina , Proctor Michael , Goldstein Louis , Wilson Stephen M. , Miller Bruce , Gorno-Tempini Maria Luisa , Narayanan Shrikanth S. 
Published: March 2017

PurposeReal-time magnetic resonance imaging (MRI) and accompanying analytical methods are shown to capture and quantify salient aspects of apraxic speech, substantiating and expanding upon evidence provided by clinical observation and acoustic and kinematic data. Analysis of apraxic speech errors within a dynamic systems framework is provided and the nature of pathomechanisms of apraxic speech discussed.MethodOne adult male speaker with apraxia of speech was imaged using real-time MRI while producing spontaneous speech, repeated naming tasks, and self-paced repetition of word pairs designed to elicit speech errors. Articulatory data were analyzed, and speech errors were detected using time series reflecting articulatory activity in regions of interest.ResultsReal-time MRI captured two types of apraxic gestural intrusion errors in a word pair repetition task. Gestural intrusion errors in nonrepetitive speech, multiple silent initiation gestures at the onset of speech, and covert (unphonated) articulation of entire monosyllabic words were also captured.ConclusionReal-time MRI and accompanying analytical methods capture and quantify many features of apraxic speech that have been previously observed using other modalities while offering high spatial resolution. This patient's apraxia of speech affected the ability to select only the appropriate vocal tract gestures for a target utterance, suppressing others, and to coordinate them in time.
Piezoelectric driven insect‐inspired robot with flapping wings capable of skating on the water
Authors: Zhou Sui , Zhang Weiping , Zou Yang , Ke Xijun , Cui Feng , Liu Wu 
Published: March 2017

A 165 mg coin‐size bionic water‐skating robot driven by piezoelectric (PZT) bending actuator is presented. The robot with light weight and elastic legs uses surface tension to keep itself on the water surface. The driving force produced by flapping wings enables it to glide easily due to tiny resistance coefficient of water surface. The robot consists of PZT bending actuator, four‐bar transmission structure, two flapping wings, four elastic legs and the body. The actuator bending at resonance frequency of 105 Hz achieves 346 μm displacement at the end of actuator at voltage of 280 V so that the flapping angle of the wings reaches 73° at that frequency. Tests show that, the maximum equivalent payload of robot is 830.6 mg, about five times of its own mass, before breaking the water surface, and the water drag when robot skates on the water surface is about 29 μN, 1.76% of its gravity. The maximum forward speed of the robot is measured as 151 mm/s.
Effect of Swallowing Rehabilitation Protocol on Swallowing Function in Patients with Esophageal Atresia and/or Tracheoesophageal Fistula
Authors: Serel Arslan Selen , Demir Numan , Yalcın Sule , Karaduman Ayşe , Karnak Ibrahim , Tanyel Feridun , Soyer Tutku 
Published: March 2017

Aim The aim of this study was to evaluate the results of Swallowing Rehabilitation Protocol (SRP) on swallowing function (SF) of esophageal atresia and tracheoesophageal fistula (EA-TEF) patients with pharyngeal swallowing disorder.
Materials and Methods In this study, 24 children with EA-TEF who had deglutitive and respiratory problems were grouped into either study (n = 12) or control group (n = 12) by basic randomization. Study group received the SRP including neuromuscular electrical stimulation, thermal tactile stimulation, and hyolaryngeal mobilization. The control group received nonnutritive stimulations. SF was evaluated with 3 mL liquid and pudding barium by videofluoroscopic swallowing study (VFSS) before and after 20 sessions of interventions.
Results No statistical differences were found between groups in terms of descriptive characteristics including age, sex, weight, height, type of atresia, repair type, repair time, and start time of oral intake (p > 0.05). There were no statistical differences between groups in term of swallowing parameters (p > 0.05), except reflux (p = 0.004) according to VFSS findings. After 20 sessions of interventions, the study group showed improvement in penetration–aspiration scale scores, oral phase dysfunction, delay in swallowing reflex, and residue in valleculae and pyriform sinuses after pudding swallow. The control group showed improvement only in oral phase dysfunction.
Conclusion SRP can be recommended to improve SF in patients with EA/TEF who have pharyngeal swallowing disorders.