bluuebunny/crossref_metadata_2025_split huggingface dataset:
P156 HYPERTENSIVES USERS OF A HEALTH WEB PORTAL
Authors: Bédard, J. Rousseau , Cloutier Lyne , Michaud A. 
Published: September 2024

Background and objective:
In Canada, approximately 1 in 4 adults live with high blood pressure. These people, concerned about their health, often turn to health information Web portals. To meet this need for information, Quebec Society of Vascular Sciences (QSVS) du Québec has created a web portal (www.yourvascularhealth.ca). However, limited data is available to describe the characteristics and motivations of hypertensive users of these websites.

Method
In this multicenter study, participants had to be ≥18 years old, hypertensive and able to use digital tools. They were approached by collaborating physicians (n=30) during routine consultations. An anonymous, validated electronic questionnaire assessed socio-demographic variables, digital competence, and motivations for using a health website. Adapted Technology Acceptance Model III was used as a framework.

Results:
Forty-three participants were recruited mean age of 70.3 ± 10.5 years, 67% male, 33% had achieved a university level of education. For health behaviors, less than 30% attained the 150 weekly minutes of exercise promoted in Canada while a less than half (44%) say that they eat according to DASH guidelines. The vast majority don’t smoke (67%) and drink less than once a month (86%). Preliminary analysis show that most participants (84%) use search engine. When questioned (on a Likert scale 1 to 7) about the portal, they perceived it was useful (6.0 ± 1.1), easy to use (5.4 ± 1.2) and expressed the intention of using the portal again (5.7 ± 1.5). When motivation was assessed; autonomous motivation was highest (5.83 ± 0.99) followed by amotivation (3.83 ± 1.35) and controlled motivation (3.13 ± 1.39).

Conclusion:
Patients with hypertension are consulting websites to obtain more information and this even later in life. It is our responsibility to provide websites that are designed for this population and scientifically based. This study will contribute to a better characterization of health website users and may guide the development and dissemination of health websites.
P164 SOLUBLE GUANYLATE CYCLASE STIMULATORS: AN EMERGING OPTION IN THE TREATMENT OF PRESSURE AND VOLUME OVERLOAD INDUCED CHRONIC HEART FAILURE
Authors: Bačová Barbara Szeiffová , Sýkora Matúš , Martišková Adriana , Gawrys Olga , Tribulová Narcisa , Červenka Luděk 
Published: September 2024

Pressure and volume overload-induced chronic heart failure (HF) is associated with characteristic cardiac remodeling and ventricular myocardial proteomic alterations, that can lead to the formation of a substrate for arrhythmias. Antiarrhythmic drug therapy is still suboptimal and current therapies are not efficacious enough. The purpose of the current study was therefore to examine the efficiency of nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) stimulator.
We used as an experimental model male hypertensive Ren-2 transgenic rats (TGR) (n = 16), normotensive Hannover Sprague–Dawley rats (HSD, n = 17), and a volume-overload HF rat model induced by creating the aortocaval fistula (ACF) in rats of both strains (n = 27). Rats were after the induction of ACF treated by sGC stimulator BAY41-8543 (3 mg/kg/day for 30 weeks) alone or combined with angiotensin-converting enzyme inhibitor (ACEi) Trandolapril (0.25 mg/kg/day for 30 weeks). The age of the animals at the end of the experiment was 40 weeks. Left ventricle tissue and plasma samples were used for further analyses. Blood pressure (BP) was measured by telemetry.
Combined treatment with sGC stimulator and ACEi was the most potent in lowering BP. Moreover, supplementation by sGC stimulator alone significantly decreased mortality and increased levels of the antioxidant enzyme superoxide dismutase 1, matrix metalloproteinase 2, total and phosphorylated connexin 43 as well as protein kinase C epsilon, implicated in remodeling of extracellular matrix and intercellular communication, in the left ventricle of TGR rats. Application of the sGC stimulator also slightly normalized elevated collagen deposition and hydroxyproline content in the left ventricular tissue of TGR rats. Unfortunately, we did not observe any effect of the sGC stimulator in the TGR ACF group.
These results support the hypothesis that sGC stimulators might represent a class of drugs suitable for the prevention and treatment of related disorders in HF.
This work was supported by APVV-21-0410, VEGA 2/0006/23, and EXCELES LX22NPO5104. Supported by APVV-21-0410, VEGA 2/0006/23, and EXCELES LX22NPO5104.
P172 WHAT ARE CONSUMERS’ KNOWLEDGE, ATTITUDES, AND BEHAVIORS RELATED TO REDUCED-SODIUM SALT? A SYSTEMATIC REVIEW
Authors: Ghammachi Nadine , Kissock Katrina , Hoek Annet , Bullen James , Webster Jacqui , Neal Bruce , Trieu Kathy 
Published: September 2024

Background and objective:
Despite compelling evidence of the efficacy of reduced-sodium salt in lowering blood pressure and cardiovascular disease risk, it is currently an underutilized intervention. To inform the approaches needed to scale-up use of reduced-sodium salt, it is important to understand how it is perceived by consumers. This study systematically assessed consumers’ knowledge, attitudes, and behaviors relating to reduced-sodium salt.

Methods:
PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL) plus, Cochrane Central Register for Controlled Trials (CENTRAL) and Google Scholar (all years to 8 February 2024) were systematically searched to identify studies reporting quantitative or qualitative outcome measures of knowledge, attitudes, or behaviors related to reduced-sodium salt. Reduced-sodium salt was salt where all or a proportion of sodium chloride is replaced with a non-sodium component. The population of interest included consumers, healthcare professionals and chefs.

Results:
Twenty-eight studies from 11 countries were included. 17 were evaluations following a reduced-sodium salt intervention and 11 were descriptive studies of knowledge, attitudes, and behaviors in the general population. Intervention studies in China identified high overall acceptability, with medium-to-long-term continued use, ranging from 65 to 83% of participants despite about half reporting adverse taste differences. Rates of reduced-sodium salt use were lower among the general population groups studied (ranging from 10-16%) where interventions such as education and cost subsidization were not used. Descriptive studies without a reduced-sodium salt intervention found lower knowledge and awareness among consumers compared to healthcare professionals.

Conclusions:
Differences in taste were detectable by many but did not appear to affect overall acceptability of reduced-sodium salts. Increased awareness and knowledge about reduced-sodium salt, particularly among the general population, will be key to scaling the use of reduced-sodium salts.
P188 HYPERTENSION IN COVID-19 VACCINATED POPULATION: SUDAN MMM 2022
Authors: Ahmed Amjad M. , Beheiry Hind , Ahmed Omer 
Published: September 2024

Introduction:
Little is available in the literature about high blood pressure readings after COVID-19 vaccination. Although all launched vaccines used different mechanisms of action other than the primary disease, hypertension development after receiving COVID-19 vaccination is still questionable. In this study, we will assess the predictability of utilizing the COVID-19 vaccine in the development of hypertension.

Methods:
Utilizing Sudan MMM 2022 data, participants’ BP was measured. Hypertension is defined as blood pressure ≥140/90 mmHg. Continuous data was presented in mean and standard deviation, and categorical data was presented in frequencies and percentages. Logistic regression models (unadjusted and adjusted) were used to predict high blood pressure readings.
Result: A total of 13,938 (42.6% were male, and the mean age was 34.9±14.6 years) patients were included in the study. The prevalence of associated medical conditions, diabetes, heart attack, heart failure, arrhythmia, and stroke were 6.2%, 1.2%, 1.5%, 0.8%, 5.0%, and 1.1%, respectively. The mean SBP was 117.8±17.3, and the mean DBP was 78.1±11.0. Of the population, 4,314 (31.0%) patients have received COVID-19 vaccination. The vaccinated patients were older (37.4±14.6 vs. 33.8±14.5, p<0.001), more frequently males (48.8% vs. 39.9%, p <0.001), and diabetic (8.3% vs. 5.3%, p<0.001). The incidence of SBP≥140 mmHg, DBP≥90 mmHg, and BP≥140/90 was 9.76%, 12.66%, and 5.73% respectively. The mean SBP is higher within vaccinated patients (119.1±17.3 vs. 117.2±17.3 p<0.001) as well as mean DBP (78.9±11.0 vs. 77.7±11.3 p<0.001). Using unadjusted logistic regression, vaccination use significantly predicted both SBP≥140 (OR 1.24, 95%CI 1.11-1.39, p<0.001) and DBP≥90 (OR 1.12, 95%CI 1.01-1.25, p=0.032). However, this significant finding didn’t hold after adjustment for known confounders.

Conclusion:
The COVID-19 vaccine reduced the mortality rate significantly. Although mean SBP and DBP were high within the vaccinated group, receiving the vaccine failed to predict the SBP≥140 and DBP≥90 in the adjusted model.
P192 PREVALENCE OF HYPERTENSION AND ITS ASSOCIATED FACTORS AMONG PUBLIC VEHICLE DRIVERS IN POKHARA, NEPAL
Authors: Chapagain Nawaraj , Gahatraj Nand Ram , Neupane Dinesh 
Published: September 2024

Introduction:
Hypertension, defined as >=140/90 mm Hg or currently taking antihypertensive medicine, is a major public health concern globally, affecting individuals of all ages, backgrounds, and lifestyles. Occupational risk factors associated with hypertension are poorly studied in the context of Nepal, drivers could be at a higher risk of hypertension because of multiple shift work, stress, inactivity, and poor diet.

Methodology
This cross-sectional study recruited 358 public vehicle drivers from Pokhara Metropolitan City of Nepal. The WHO STEPS questionnaire was used to assess the prevalence of hypertension. Data were entered into REDCap software and analyzed by using SPSS. The chi-square test and binary logistic regression were applied to identify hypertension-related factors.

Results:
The mean age of the participants was 37.3 ±8.5 years, and all of them were male. The prevalence of hypertension was found to be 41.9%. Using the chi-square test, hypertension was found to be associated with age, lower education, being married, tobacco consumption, age of smoking initiation, alcohol consumption, binge alcohol intake, lower physical activity, obesity, duration of driving, and service. However, when using binary logistic regression, the association was found only with age (OR=0.353; 95% CI: 0.183 to 0.680) and obesity (OR=0.429; 95% CI: 0.234 to 0.783).

Conclusion:
This study concludes that nearly two-fifths of drivers had hypertension, which is higher than the prevalence in the general population. The research highlights the need to focus on risk factors associated with hypertension among public vehicle drivers in Pokhara, Nepal.
P197 PULSE WAVE ANALYSIS IN POST COVID PATIENTS WITH AND WITHOUT DE NOVO ARTERIAL HYPERTENSION. HOSPITAL UNIVERSITARIO DE LOS ANDES (HULA) VENEZUELA. 2021-2023
Authors: Medina Cabrita Jose Daniel , Aranguren Vielma Vanessa Coromoto , Serrano Marco Aurelio , Rivera Jesus Lopez , Quiñonez Magaly , Zambrano Carlos 
Published: September 2024

Background and Objective:
COVID 19 infection is characterized by an acute respiratory process that can range from mild to severe and has been related to short- and long-term complications. Post COVID 19 syndrome has been described among these long-term complications, where alterations in pulse wave velocity define vascular alteration, increasing risk of systemic arterial hypertension. The objective is analyze pulse wave velocity and arterial stiffness in post-COVID 19 patients with and without de novo arterial hypertension at the HULA, Venezuela between 2021-2023.

Methods:
Observational case-control study on pulse wave velocity in post-COVID-19 patients with and without de novo arterial hypertension in the HULA post-COVID-19 consultation, 2021-2023.

Results:
The sample consisted of 90 patients: 30 cases and 60 controls, there was no statistically significant difference in variables such as sex, body mass index (BMI) and abdominal circumference between both cohorts, with a predominance of the age group between 35 to 49 years with 33.3%, and less frequency at the extremes of life, where the group of 18-34 years and over 65 corresponded to 20%, there was a statistically significant association between syndrome post COVID 19 and arterial stiffness, the risk of de novo arterial hypertension was found to be 4.9 times and 7.9 times higher in the small and large vessel arterial stiffness group compared to the group without arterial stiffness, respectively.

Conclusions:
It is impressive that the age group between 35 and 49 years has a higher risk of developing arterial hypertension associated with COVID 19, the alteration of pulse wave analysis in the patients in the consultation post COVID 19 was associated with a higher risk of developing de novo arterial hypertension compared to those who did not present alterations.
P200 INCIDENCE OF LENVATINIB INDUCED ARTERIAL HYPERTENSION IN THYROID CARCINOMA: A RETROSPECTIVE ANALYSIS OF A SERIES OF CASES
Authors: Rivera Martínez Wilfredo Antonio , Castaño María Johana Ramírez , Salazar Solarte Aura María , Oliveros Pierce Sebastián , Echeverri Rendón Ángela Patricia , Villegas Jaime Gallo , Ocampo Dagnóvar Aristizábal , Restrepo Johnayro Gutiérrez , González Alejandro Román 
Published: September 2024

Background and Objective:
Advanced thyroid cancer leads to worse overall survival and a higher risk of locoregional recurrence. Tyrosine kinase inhibitors have emerged as a management alternative in these conditions. However, serious adverse effects such as high blood pressure are common in clinical trials and real-life studies. The objective of this study was to evaluate the incidence of arterial hypertension in patients undergoing treatment for advanced thyroid cancer with the tyrosine kinase inhibitors lenvatinib

Methods
This is a retrospective cohort study of patients with advanced thyroid cancer being managed with Lenvatinib, a tyrosine kinase inhibitor. The incidence of arterial hypertension after the start of treatment was evaluated.

Results
Among the subjects included in the study (n=26), the mean age was 64.6 ±11.8; 57.7% were women and hypertension occurred in 88.5% (23/26), being CTCAE grade ≥ 3 in 43.5% (10/23). In 12 of 23 it occurred due to exacerbation of pre-existing hypertension and in 10 of 23 it corresponded to de novo hypertension induced by the drug. A patient presented grade 4 hypertension due to posterior reversible encephalopathy syndrome. 6 patients died during follow-up, all developed hypertension during treatment with Lenvatinib.

Conclusions:
High blood pressure is a common and early adverse effect in the management of advanced thyroid cancer with Lenvatinib. Management strategies to improve drug tolerability may improve disease outcomes, treatment adherence and patient-related outcomes.
P202 KNOW YOUR NUMBERS AND GET THEM RIGHT: HOW MANY AND WHAT KIND OF PATIENTS KNOW THEIR BP TARGETS AND LEVELS IN BOGOTÁ?
Authors: Cruz Cuevas José D. , Villar Juan Carlos , Moreno Angélica M. 
Published: September 2024

Background and objective:
Patient's knowledge of their disease and goals is a key component for achieving blood pressure (BP) control in patients with hypertension. Several guidelines and public health campaigns promote patient self-monitoring of BP levels and knowing their goals. The aim of this study was to estimate the proportion of patients meeting both knowledge of their BP targets and able to report their BP levels, as well as exploring their characteristics compared with unaware patients.

Methods
we performed a cross-sectional study with adults previously diagnosed hypertension from 6 out-patient clinics from different institutions in Bogotá, Colombia. Consenting participants answered a phone call survey regarding their disease, follow-up, treatment and knowledge. Participants were classified in three groups: those knowing both BP targets (systolic <140mmHg and diastolic <80mmHg) and their BP levels, those knowing either one of them, or those not knowing neither. We report sociodemographic and clinical characteristics using descriptive statistics and tested hypothesis of inter-group difference with Chi-square or ANOVA as appropriate.

Results
From 5051 patients invited, 1675 answered the survey (mean age of 66.3, 74% female, and mean time after diagnosis 11.3 years). From this population, 24% (95%CI 21.9-26.1%) knew both BP targets and their own levels while 38.5% (95%CI 36.1-40.8%) knew neither. Patients who knew BP levels and target were younger, more frequently male, resided in a higher socioeconomical area, had a higher educational level, and used more antihypertensive medications (table 1). Among 707 patients who reported the BP levels, awareness of target and levels did not translate into differences in systolic or diastolic pressure.

Conclusions
most patients with hypertension are unaware of BP targets or know their BP levels. Those knowing BP targets and levels were in better sociodemographic conditions than those who did not. However, being aware does not necessarily implies lower BP levels. Awareness campaigns in the future should prioritize patients with more social disadvantages.
P215 EFFECT OF OXYGEN LOADING MODEL ON RETINOPATHY OF PREMATURITY IN INTRAUTERINE GROWTH RETARDED MICE
Authors: Mogi Masaki , Watanabe Ryusuke , Liu Shuang , Eguchi Mariko 
Published: September 2024

Background and Objective:
Fetal growth retardation (IUGR) not only induces various complications in newborns, but is also known to be associated with the future development of lifestyle-related diseases and conditions. Therefore, the neonatal treatment often struggles between life-sustaining and oxygen administration. We have previously reported that IUGR mice born from mothers raised on a low-protein diet show enhanced vascular remodeling. The mechanism is influenced by an increased inflammatory response associated with a decreased angiogenic response due to hypoxic loading in a femoral artery cuff implantation model. Based on this, we hypothesized that in IUGR mice, the reduced angiogenic response in retinopathy of prematurity may work to suppress the onset of the disease. To test this hypothesis, we examined the effects of oxygen loading on the retinal neovasculature using the mouse oxygen-induced retinopathy of prematurity (OIR) model.

Methods
The OIR model was created in newborns born from mothers raised on a normal protein diet (20%) and in IUGR newborns born from mothers raised on a low protein diet (8%). Specifically, the newborns were exposed to 75% hyperoxia for 5 days starting at 7 days of age, and retinal neovascularization was histologically evaluated 5 days later at 17 days of age for comprehensive transcriptome analysis.

Results:
Compared to normal birth weight OIR mice, retinal neovascularization was significantly suppressed in OIR mice with FGR. Retinal RNA sequencing revealed decreased expression of angiogenic factors that trigger pathological retinal neovascularization, such as the mitogen-activated protein kinase pathway (MAPK) pathway and corresponding upstream signaling pathways.

Conclusions
Our findings suggest that IUGR neonates have a weaker response to retinal oxygen stress and consequently are likely to have reduced retinopathy of prematurity. These results indicate that the risk of developing retinopathy of prematurity is attenuated in IUGR neonates compared to mature neonates with normal birth weight.
P220 APOL 1 RISK GENOTYPE IS ASSOCIATED WITH ALBUMINURIA IN SUB-SAHARAN AFRICAN WITHOUT HYPERTENSION: A CASE STUDY OF TRYPANOSOMA BRUCEI GAMBIENSE ENDEMIC AREA
Authors: Mupepe Dominique , Bayauli Pascal , Buila Nathan , Situakibanza Hippolyte , Ekulu Pépé , Wameso Marie-Noelle , Van Den Heuvel Lambertus P. , Levtchenko Elena , Mumba Dieudonné , M’buyamba-Kabangu Jean René 
Published: September 2024

Background and Objective.
An association between APOL1 risk genotypes and hypertension has been reported in African Americans with chronic kidney diseases (CKD). However, such data from African populations living in a Human African Trypanosomiasis (HAT) area remain limited. This study assessed the association between APOL1 high-risk genotypes (HRG) and hypertension among sub-Saharan African in T.b. gambiense endemic area.

Methods.
This cross-sectional study enrolled 94 HAT-infected and 144 non–infected participants in Masimanimba, the Democratic Republic of the Congo, from April 2019 to April 2021. APOL1 HRG was defined as the presence of two risk variants (G1/G1, G2/G2, or G1/G2), and a low-risk genotype (LRG) with the presence of 0 or 1 single variant. The elevated albuminuria was defined as urinary albumin/creatinine ratio ≥ 30 mg/g. Student's and Pearson's Chi2 tests or Fisher's exact test were used to compare means and proportions. Statistical significance was set at p < 0.05, based on 2-tailed test.

Results.
APOL1 sequence analysis revealed that 3 of 21 (14.3%) hypertensive participants carried HRG (G1G1) and 7 of 103 (6.8%) non-hypertensive carried HRG (G1G1, G2G2, and G1G2) (p=0.371). Ten of 21 (47.6%) hypertensive individuals with elevated albuminuria had a higher incidence of CKD (100% vs. 0%; p < 0.001) and HRG (30% vs. 0%; p = 0.09) than 11 (52.3%) without albuminuria who carried LRG. Of 103 non-hypertensive subjects, 43 (41.7%) with elevated albuminuria had a higher frequency of HRG (16.3% vs. 0%; p = 0.002) and CKD (100% vs. 1.7%; p<0.001) compared with 60 of 103 (58.3%) without albuminuria who carried LRG.

Conclusion.
APOL1 HRG was associated with albuminuria and CKD, regardless of the hypertension status in T.b. gambiense HAT endemic area.
P222 PREDICTOR FACTORS OF UNCONTROLLED MASKED HYPERTENSION IN PATIENTS WITH HYPERTENSION WITH CHRONIC KIDNEY DISEASE
Authors: Santos Roberto , Silva Gabriel Fernandes , Drager Luciano F. , Pio-Abreu Andrea 
Published: September 2024

Background and Objective:
Masked uncontrolled hypertension (MUCH) is commonly observed in patients with hypertension who are normotensive in the clinic. MUCH is associated with increased risk for target- organ damage and adverse cardiovascular and renal outcomes in high-risk patients, such as those with chronic kidney disease (CKD). The objective of this study was to evaluate predictors of MUCH in patients with hypertension and CKD.

Methods:
This was cross-sectional study that performed 24-hour ambulatory blood pressure (BP) monitoring (ABPM) in 220 patients with hypertension and CKD (glomerular filtration rate <60 mL/min/1.73 m2) and controlled BP in the office (<140/90 mmHg). We categorized participants into two groups: 1) controlled BP group (24-hour ABPM <130/80 mmHg), and 2) MUCH group (24-hour ABPM ≥130/80 mmHg). Epidemiological, clinical, anthropometric variables and laboratory data were collected and compared between the two groups. We used logistic-regression models to identify the predictors of MUCH.

Results:
Approximately half of patients (n=109, 49.6%) had MUCH. Higher office BP values were observed in patients classified as controlled BP, both systolic (127 vs 125 mmHg, p=0.06) and diastolic BP (75 vs 72 mmHg, p=0.01). When analyzing anthropometric variables, a higher body mass index (BMI) was noted in the controlled BP group (26 vs 28 kg/m2, p<0.01). Regarding laboratory data, higher levels of urine albumin-creatinine ratio (uACR) were observed in the MUCH group (275 vs 69 mg/g, p<0.01). In a logistic regression model, were significant: diastolic BP in the office between 75 and 89 mmHg (OR: 1.93, 95%CI 1.03-3.64; p=0.04), BMI <25Kg/m2 (OR: 2.21, 95%CI 1.08-4.52; p=0.03) and uACR greater than 300 mg/g (OR: 3.26, 95%CI 1, 71-6.19; p<0.01).

Conclusion:
In patients with CKD and BP controlled at the office, diastolic BP in the office between 75 and 89 mmHg, BMI <25 kg/m2 and uACR >300 mg/g were predictive factors for MUCH.