bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysing how cultural factors influence the efficiency of tourist destinations in Chile
Authors: Figueroa Víctor , Herrero Luis César , Báez Andrea , Gómez Mafalda 
Published: August 2017

AbstractThe present work is framed within the line of research addressing efficiency evaluation of tourist destinations, where regions are taken as territorial units able to determine their tourist appeal, and tourist flow is taken as the variable to be optimized. A virtual production function is therefore devise considering tourist flows as output and accommodation capacity and other tourist and cultural resources as the main inputs. We examine Chile as case study, a country with a growing number or tourists and increased investment in tourist and cultural infrastructures. We follow a two‐stage model, estimating regional performance using data envelopment analysis and analysing the impact of external variables on efficiency applying bootstrap techniques and truncated regression models. Empirical results show that cultural endowments and activities together with natural resources determine Chilean regional efficiency in optimizing tourist flow, particularly in attracting international tourism. Thus, policy recommendations to improve regional management of tourist and cultural attractions are derived. This study contributes to increase applications in tourist destinations efficiency in Latin America, where works are still scarce.
Effects of rangeland management on survival of female greater prairie‐chickens
Authors: Winder Virginia L. , McNew Lance B. , Pitman James C. , Sandercock Brett K. 
Published: August 2017

ABSTRACTIdentifying relationships between habitat selection and population processes is important for habitat management and wildlife conservation. For prairie‐obligate species, space use and demography in extant grasslands are influenced by habitat conditions caused by rangeland management practices associated with livestock production. Greater prairie‐chickens (Tympanuchus cupido) are an indicator species for native tallgrass prairie ecosystems, but populations have declined in the Flint Hills ecoregion of eastern Kansas, USA because of intensification of rangeland management practices, including annual prescribed fire and high stocking densities. Patch‐burn grazing is a rotational system that provides heterogeneous habitats and can improve productivity of grassland birds, but the effects of grazing systems on habitat use or survival of greater prairie‐chickens are unknown. We used 3 types of survival analyses to investigate impacts of rangeland management on female greater prairie‐chickens in the central Flint Hills during 2011–2013: Kaplan–Meier models and Cox proportional hazards to examine factors affecting annual survival rates, hazard functions to assess seasonal patterns of mortality, and Andersen–Gill models to explore the links between habitat selection and cause‐specific mortality risk. Females captured at properties managed with patch‐burn grazing had annual survival rates (0.61 ± 0.07 SE) that were 35% higher than females on properties managed with annual burning and intensive early cattle stocking (0.45 ± 0.06). Moreover, females that selected habitats associated with intensive management had increased mortality risk and were particularly vulnerable to avian predators, whereas females that selected habitats created by patch‐burn grazing experienced lower overall mortality risk but were more vulnerable to mammalian predators. Overall mortality risk was significantly reduced under patch‐burn grazing management, and widespread implementation of annual spring burning and intensive early stocking is likely depressing survival of greater prairie‐chickens in the Flint Hills ecoregion. Our results join a growing body of evidence that patch‐burn grazing can provide higher quality grassland habitats for native wildlife species than current rangeland management associated with intensive cattle production. © 2017 The Wildlife Society
Novel Core–Shell PS‐co‐PBA@SiO2 Nanoparticles Coated on PP Separator as “Thermal Shutdown Switch” for High Safety Lithium‐Ion Batteries
Authors: Liao Haiyang , Zhang Haiyan , Qin Gai , Hong Haoqun , Li Zhenghui , Lin Yingxi , Li Liuqing 
Published: August 2017

AbstractThermal runaway is a hazardous behavior of lithium‐ion batteries under extreme conditions and is mainly cause for restraint of its commercial applications in development of high‐power and high‐rate lithium‐ion batteries. In this paper, a new dual‐functions coating layer fabricated from polystyrene‐poly(butyl acrylate) copolymer encapsulated silica nanoparticles as “thermal shutdown switch” with a reasonable shutdown temperature of ≈80 °C is designed and coated on polypropylene separator. The shell polymer owing to its self‐adhesion upon glass transition temperature (Tg) can retard off the Li+ conduction between the electrodes, thus prevents cell from thermal runaway, the core nanoparticles protect the separator from significantly thermal shrinkage when the cell temperature keeps going up. Moreover, the coated separator has no negative affection on the normal electrochemical performance of the batteries, thereby implying that this coating layer provides a simple and effective approach to control the safety of commercial lithium‐ion batteries by internal self‐protecting.
Symptom clusters in adults with inflammatory bowel disease
Authors: Conley Samantha , Proctor Deborah D. , Jeon Sangchoon , Sandler Robert S. , Redeker Nancy S. 
Published: August 2017

ABSTRACTSymptoms (pain, fatigue, sleep disturbance, depression, and anxiety) in inflammatory bowel disease (IBD) are associated with reduced quality of life. Understanding how IBD symptoms cluster and the clinical and demographic factors associated with symptom clusters will enable focused development of symptom management interventions. The study purposes were to (i) identify symptom cluster membership among adults with IBD and (ii) examine associations between demographic (age, gender, race/ethnicity, and education) and clinical factors (smoking status, time since diagnosis, medication type, IBD type, disease activity), and membership in specific symptom cluster groups. We conducted a retrospective study of data from the Crohn's and Colitis Foundation of America's (CCFA) Partners Cohort and used Patient Reported Outcome Measurement Information System (PROMIS) measures to measure pain interference, fatigue, sleep disturbance, anxiety, and depression. The sample included 5,296 participants with IBD (mean age 44, 72% female). In latent class analysis (LCA), four groups of participants were identified based on symptoms: “low symptom burden” (26% of sample), “high symptom burden” (38%), “physical symptoms” (22%), and “psychological symptoms” (14%). In multinomial regression, female gender, smoking, corticosteroids, Crohn's disease, and active disease state were associated with membership in the high symptom burden group. Additional research is needed to test interventions that may be effective at reducing symptom burden for individuals with IBD.
Association Between Peripheral Adipokines and Inflammation Markers: A Systematic Review and Meta‐Analysis
Authors: Graßmann Sophie , Wirsching Jan , Eichelmann Fabian , Aleksandrova Krasimira 
Published: August 2017

ObjectiveObesity‐induced inflammation potentially promotes a variety of chronic conditions. This study aimed to summarize cross‐sectional associations between adipose tissue‐derived hormones (leptin and adiponectin) and inflammatory biomarkers (C‐reactive protein [CRP], interleukin [IL]‐6, and tumor necrosis factor [TNF]‐α) by means of meta‐analysis.MethodsA systematic search of the databases EMBASE and MEDLINE (PubMed) up to January 2017 was conducted. Data were independently extracted and evaluated by two reviewers. Pooled effect sizes and 95% confidence intervals were calculated using random‐effects models.ResultsAfter the initial search, 5,907 publications were retrieved; of these, an overall 60 studies with 45,210 participants were deemed eligible for inclusion in the meta‐analysis. Positive correlations with inflammatory biomarkers were observed for leptin (pooled Rho = 0.35, 0.20, and 0.20 for CRP, IL‐6, and TNF‐α, respectively), whereas the respective correlations with adiponectin were negative (pooled Rho = −0.18, −0.14, and −0.12 for CRP, IL‐6, and TNF‐α, respectively). Stratification by age showed that the observed correlations tended to be weaker with the increasing age of participants. No apparent differences were observed by sex and adiposity status.ConclusionsThis is the first quantitative synthesis of human studies on the association between circulating adipokines and inflammation biomarkers. Potential influence of age on these associations requires further evaluation.
Simultaneous actuator and sensor fault estimation for discrete‐time Lipschitz nonlinear systems in finite‐frequency domain
Authors: Gu Ying , Yang Guang‐Hong 
Published: August 2017

SummaryThis paper addresses the problem of actuator and sensor fault reconstruction simultaneously with finite‐frequency specifications for discrete‐time Lipschitz nonlinear systems. First, an augmented system description is given by extending the sensor fault as an auxiliary state vector. Then, a multiobjective unknown input proportional‐integral observer is designed, and the nonlinear error dynamics are transformed into a linear parameter‐varying system based on the use of a reformulated Lipschitz property. Sufficient conditions for the design of a fault estimator with 2 finite‐frequency
performances are derived in terms of linear matrix inequalities where a slack variable is introduced to reduce the conservativeness of the design. The proposed method can provide less restrictive linear matrix inequality conditions and get a better fault estimation performance than the existing one in the full frequency domain. Simulation results are given to show the effectiveness of the proposed techniques.
Whole genome sequencing identifies etiology of recurrent male intrauterine fetal death
Authors: Shehab Omar , Tester David J. , Ackerman Nicholas C. , Cowchock F. Susan , Ackerman Michael J. 
Published: August 2017

AbstractObjectiveTo identify the underlying genetic cause for recurrent intrauterine fetal death (IUFD) of males.MethodsWhole genome sequencing was performed on DNA from five healthy obligatory carrier females and an unaffected male offspring of a multigenerational pedigree with recurrent second‐trimester IUFD of males (n = 19). When documented, all deaths occurred at ≤20 weeks of gestation. Hydrops fetalis was diagnosed at death in the most recent case.ResultsFollowing variant filtering based on a recessive X‐linked inheritance pattern, a rare FOXP3 frameshift mutation (p.D303fs*87) that results in a premature truncation of the protein was discovered. Sanger sequencing confirmed the mutation in the affected fetus. The FOXP3 gene encodes for a transcriptional regulator critical to the function of regulatory T cells. FOXP3 mutations are associated with immune dysregulation, polyendocrinopathy, enteropathy, and X‐linked (IPEX) syndrome which exclusively affects males and may present with a potentially life‐threatening complex autoimmune disorder in early childhood.ConclusionsHere, we demonstrate the utility of whole genome sequencing‐based pedigree analysis to identify the genetic cause for recurrent IUFD when chromosome studies, including microarray analysis, are normal. Further studies are needed to determine the prevalence of FOXP3‐mediated IUFD in males. © 2017 John Wiley & Sons, Ltd.
Structures and thermochemistry of methyl ethyl sulfide and its hydroperoxides: HOOCH2SCH2CH3, CH3SCH(OOH)CH3, CH3SCH2CH2OOH, and radicals
Authors: Song Guanghui , Bozzelli Joseph W. 
Published: August 2017

AbstractHydroperoxides and the corresponding peroxy radicals are important intermediates during the partial oxidation of methyl ethyl sulfide (CH3SCH2CH3) in both atmospheric chemistry and in combustion. Structural parameters, internal rotor potentials, bond dissociation energies, and thermochemical properties (ΔHfo, So and Cp(T)) of 3 corresponding hydroperoxides CH2(OOH)SCH2CH3, CH3SCH(OOH)CH3, CH3SCH2CH2OOH of methyl ethyl sulfides, and the radicals formed via loss of a hydrogen atom are important to understanding the oxidation reactions of MES. The lowest energy molecular structures were identified using the density functional B3LYP/6‐311G(2d,d,p) level of theory. Standard enthalpies of formation (ΔHfo298) for the radicals and their parent molecules were calculated using the density functional B3LYP/6‐31G(d,p), B3LYP/6‐31 + G(2d,p), and the composite CBS‐QB3 ab initio methods. Isodesmic reactions were used to determine ∆Hfo values. Internal rotation potential energy diagrams and rotation barriers were investigated using the B3LYP/6‐31G(d,p) level theory. Contributions for So298 and Cp(T) were calculated using the rigid rotor harmonic oscillator approximation based on the structures and vibrational frequencies obtained by the density functional calculations, with contributions from torsion frequencies replaced by internal rotor contributions. The recommended values for enthalpies of formation of the most stable conformers of CH3SCH2CH2, CH2(OOH)SCH2CH3, CH3SCH(OOH)CH3, and CH3SCH2CH2OOH are −14.0, −33.0, −37.2, and −32.7 kcal/mol, respectively. Group additivity values were developed for estimating properties of structurally similar and larger sulfur‐containing peroxides. Groups for use in group additivity estimation of sulfur peroxide thermochemical properties were developed.
Mechanosynthesis of a Copper complex for redox initiating systems with a unique near infrared light activation
Authors: Garra P. , Dumur F. , Morlet‐Savary F. , Dietlin C. , Gigmes D. , Fouassier J. P. , Lalevée J. 
Published: August 2017

ABSTRACTThe first use of a new mechanosynthesized copper complex (Cu(acac)(2dppba)) as a initiator for the redox and redox photoactivated polymerization of methacrylates under air is proposed. This paper (i) describes the mechanosynthesis of this complex, (ii) outlines the relative efficiency of the complex for redox polymerization (mechanosynthesized product vs. solvent synthesized product), (iii) follows the polymerization enhancement under a 405 nm light, and (iv) demonstrates the high performance of this complex in near infrared photoactivated redox polymerization where a completely colorless polymer is obtained (unprecedented under NIR irradiations, 785 nm, here). The light activated polymerization exhibit higher conversions, better time controls (activation control) and higher surface conversions than redox polymerization. The mechanosynthesis is well characterized by two solvent‐free methods (visual color change and Electron Spin Resonance) and two solvent‐based methods (high resolution‐electrospray ionization‐mass spectrometry (HR‐ESI‐MS) and UV–vis spectrometry). The involved mechanisms are discussed. Mechanosynthesis of copper complexes opens new perspectives for copper (photo)redox polymerization catalysts as the environmental impact and economical costs of the complex synthesis are significantly reduced. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 3646–3655
Extramedullary plasmacytoma in the airway of an HIV‐positive child
Authors: Goussard Pierre , Kappos Alexia , Janson Jacques 
Published: August 2017

AbstractWe describe a case of an extramedullary plasmacytoma (EMP) in an HIV‐positive child. An 11‐ year‐old, HIV‐infected female patient, on antiretroviral therapy since 2010, was referred with difficult to control asthma and bronchiectasis. The lesion was identified on CT chest following persisting reduced air entry and unilateral wheezing on the right. Rigid bronchoscopy identified a large pedunculated fleshy mass in the right main bronchus. Biopsy revealed it to be a plasmacytoma. Right main bronchus sleeve resection was done with complete removal of the tumor. Histology confirmed it to be a solitary plasmacytoma localized to the right main bronchus.
Greenhouse and field‐based studies on the distribution of dimethoate in cotton and its effect on Tetranychus urticae by drip irrigation
Authors: He Jiangtao , Zhou Lijuan , Yao Qiang , Liu Bo , Xu Hanhong , Huang Jiguang 
Published: August 2017

AbstractBACKGROUNDThe two‐spotted spider mite, Tetranychus urticae Koch is an important pest of cotton. We investigated the efficacy of dimethoate in controlling T. urticae by drip irrigation. Greenhouse and field experiments were carried out to determine the efficacy of dimethoate to T. urticae and the absorption and distribution of dimethoate in cotton.RESULTSGreenhouse results showed that cotton leaves received higher amounts of dimethoate compared with cotton roots and stems, with higher amounts in young leaves compared with old leaves and cotyledon having the lowest amounts among leaves. Field results showed the efficacy of dimethoate to T. urticae by drip irrigation varied by volume of dripping water, soil pH and dimethoate dosage. Dimethoate applied at 3.00 kg ha–1 with 200 m3 ha–1 water at weak acidic soil pH (5.70–6.70) through drip irrigation can obtain satisfactory control efficacy (81.49%, 7 days) to T. urticae, without negatively impacting on its natural enemy Neoseiulus cucumeris. The residue of dimethoate in all cotton seed samples were not detectable.CONCLUSIONSThese results demonstrate the effectiveness of applying dimethoate by drip irrigation for control of T. urticae on cotton. This knowledge could aid in the applicability of dimethoate by drip irrigation for field management of T. urticae populations. © 2017 Society of Chemical Industry
Limited fitness costs of herbicide‐resistance traits in Amaranthus tuberculatus facilitate resistance evolution
Authors: Wu Chenxi , Davis Adam S , Tranel Patrick J 
Published: August 2017

AbstractBACKGROUNDThe fitness cost of herbicide resistance (HR) in the absence of herbicide selection plays a key role in HR evolution. Quantifying the fitness cost of resistance, however, is challenging, and there exists a knowledge gap in this area. A synthetic (artificially generated) Amaranthus tuberculatus population segregating for five types of HR was subjected to competitive growth conditions in the absence of herbicide selection for six generations. Fitness costs were quantified by using a combination of phenotyping and genotyping to monitor HR frequency changes over generations.RESULTSIn the absence of herbicide selection, a significant fitness cost was observed for resistance to acetolactate synthase‐inhibiting herbicides, but not for resistances to atrazine (non‐target‐site resistance mechanism), protoporphyrinogen oxidase inhibitors, 4‐hydroxyphenylpryuvate dioxygenase inhibitors or glyphosate. Glyphosate resistance was conferred by multiple mechanisms in the synthetic population, and further analysis revealed that one mechanism, amplification of the 5‐enolypyruvylshikimate‐3‐phosphate synthase gene, did decrease in frequency.CONCLUSIONOur results indicate that herbicide‐resistance mitigation strategies (e.g. herbicide rotation) that rely on the existence of fitness costs in the absence of herbicide selection likely will be largely ineffective in many cases. © 2017 Society of Chemical Industry
Coherent anti‐Stokes Raman scattering (CARS) spectroscopy in Caenorhabditis elegans and Globodera pallida: evidence for an ivermectin‐activated decrease in lipid stores
Authors: Smus Justyna P , Ludlow Elizabeth , Dallière Nicolas , Luedtke Sarah , Monfort Tual , Lilley Catherine , Urwin Peter , Walker Robert J , O'Connor Vincent , Holden‐Dye Lindy , Mahajan Sumeet 
Published: August 2017

AbstractBACKGROUNDMacrocyclic lactones are arguably the most successful chemical class with efficacy against parasitic nematodes. Here we investigated the effect of the macrocyclic lactone ivermectin on lipid homeostasis in the plant parasitic nematode Globodera pallida and provide new insight into its mode of action.RESULTSA non‐invasive, non‐destructive, label‐free and chemically selective technique called Coherent anti‐Stokes Raman scattering (CARS) spectroscopy was used to study lipid stores in G. pallida. We optimised the protocol using the free‐living nematode Caenorhabditis elegans and then used CARS to quantify lipid stores in the pre‐parasitic, non‐feeding J2 stage of G. pallida. This revealed a concentration of lipid stores in the posterior region of J2 s within 24 h of hatching which decreased to undetectable levels over the course of 28 days. We tested the effect of ivermectin on J2 viability and lipid stores. Within 24 h, ivermectin paralysed J2 s. Counterintuitively, over the same time‐course ivermectin increased the rate of depletion of J2 lipid, suggesting that in ivermectin‐treated J2 s there is a disconnection between the energy requirements for motility and metabolic rate. This decrease in lipid stores would be predicted to negatively impact on J2 infective potential.CONCLUSIONThese data suggest that the benefit of macrocyclic lactones as seed treatments may be underpinned by a multilevel effect involving both neuromuscular inhibition and acceleration of lipid metabolism. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Pycnogenol Cytotoxicity in Pancreatic INS‐1E β cells Induced by Calcium Dysregulation
Authors: Viskupicova Jana , Zizkova Petronela , Rackova Lucia , Horakova Lubica 
Published: August 2017

Natural standardized flavonoid extract from the bark of Pinus pinaster, Pycnogenol (Pyc), was recently found to decrease intensively the activity of sarcoplasmic reticulum Ca2+‐ATPase of rabbit skeletal muscle (SERCA1). On the basis of this inhibitory effect in a cell‐free system and similarities of SERCA1 to its other isoforms, proapoptotic properties of Pyc may be expected in cellular systems. Pycnogenol (40–100 μg/mL) induced a concentration‐dependent decrease of the viability of pancreatic INS‐1E β cells associated with induction of apoptosis. In addition, intracellular Ca2+ level increase was found along with reduction of protein expression level of SERCA2b and impairment of insulin secretion by β cells. These facts indicate that Pyc may induce apoptosis by impairment of calcium homeostasis. Copyright © 2017 John Wiley & Sons, Ltd.
Run Rules median control charts for monitoring process mean in manufacturing
Authors: Tran Kim Phuc 
Published: August 2017

AbstractRecent studies show that Shewhart median (
) chart is simpler than the Shewhart
chart and it is robust against outliers, but it is often rather inefficient in detecting small or moderate process shifts. The statistical sensitivity of a Shewhart control chart can be improved by using supplementary Run Rules. In this paper, we propose the Phase II median Run Rules type control charts. A Markov chain methodology is used to evaluate the statistical performance of these charts. Moreover, the performance of proposed charts is investigated in the presence of a measurement errors and modelled by a linear covariate error model. An extensive numerical analysis with several tables and figures to show the statistical performance of the investigated charts is provided for both cases of measurement errors and no measurement errors. An example illustrates the use of these charts.