bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venous Thromboembolism: A Comparison of Chronic Spinal Cord Injury and General Surgery Patients in a Metropolitan Veterans Affairs Hospital
Authors: Moore Ryan M. , Rimler Jonathan , Smith Brian R. , Wirth Garrett A. , Paydar Keyianoosh Z. 
Published: October 2016

Background:
Venous thromboembolic events result in significant morbidity, mortality, and costly therapeutic interventions. As medical resource allocation strategies are becoming more pervasive, appropriate risk stratification and prophylactic regimens are essential. Previous studies have shown a decreased incidence of perioperative venous thromboembolism in the chronic spinal cord injury population. The question remains of whether chronic spinal cord injury is protective against venous thromboembolism.

Methods:
A retrospective review of all cases involving chronic spinal cord injury patients who underwent plastic and reconstructive surgery operations (n = 424) and general surgery patients (n = 777) with a primary outcome of deep venous thrombosis or pulmonary embolism within 90 days of surgery was performed.

Results:
The incidence of postoperative deep venous thrombosis in the control and spinal cord injury groups was 1.7 percent and 0.2 percent, respectively (p = 0.027). However, such significance was not observed with regard to postoperative pulmonary embolism incidence (p = 0.070). Collectively, the incidence of postoperative venous thromboembolism—specifically, deep venous thrombosis or pulmonary embolism—was significantly greater in the general surgery population (p = 0.014). A nearly 10-fold increased risk of venous thromboembolism was seen among the control group (1.9 percent versus 0.2 percent) despite administration of optimal prophylaxis.

Conclusions:
This study demonstrates a profoundly low incidence of venous thromboembolism among chronic spinal cord injury patients compared with general surgery patients. Future efforts to elucidate how chronic spinal cord injury confers a protective mechanism may potentially influence the evolution of venous thromboembolism prevention guidelines, and spark the development of alternative prophylactic agents or customized application of prevention efforts.
Alternating dynamics of segregation and integration in human brain functional networks during working-memory task
Authors: Zippo Antonio G. , Della Rosa Pasquale A. , Castiglioni Isabella , Biella Gabriele E. M. 
Published: October 2016

AbstractBrain functional networks show high variability in short time windows but mechanisms governing these transient dynamics still remain unknown. In this work we studied the temporal evolution of functional brain networks involved in a working memory task while recording high-density electroencephalography in human normal subjects. We found that functional brain networks showed an initial phase characterized by an increase of the functional segregation index followed by a second phase where the functional segregation fell down and the functional integration prevailed. Notably, wrong trials were associated with different sequences of the segregation-integration profile and measures of network centrality and modularity were able to catch crucial aspects of the oscillatory network dynamics. Additionally, computational investigations further supported the experimental results. The brain functional organization may respond to the information processing demand of a working memory task following a 2-step atomic scheme wherein segregation and integration alternately dominate the functional configurations.
Methods for detecting co-mutated pathways in cancer samples to inform treatment selection
Authors: Jiang Tingting , Shaham Uri , Parisi Fabio , Halaban Ruth , Safonov Anton , Kluger Harriet , Weissman Sherman , Chang Joseph , Kluger Yuval 
Published: October 2016

AbstractTumor genomes evolve through a selection of mutations. These mutations may complement each other to promote tumorigenesis. To better understand the functional interactions of different processes in cancer, we studied mutation data of a set of tumors and identified significantly co-mutated pathways. Fisher’s exact test is a standard approach that can be used to assess the significance of the joint dysregulation of pathways pairs across a patient population. We developed a robust test to identify co-occurrence using DNA mutations, which overcomes deficiencies of the Fisher’s exact test by taking into account the large variability in overall mutation load and sequencing depth. Applying our method to a study of six common cancer types, we identify enrichment of co-mutated signal transduction pathways such as IP3 synthesis and PI3K and pairs of co-mutated pathways involving other processes such as immunity and development. We observed enrichment of clonal co-mutation of the proteasome and apoptosis pathways in colorectal cancer, which suggests potential mechanisms for immune evasion.
Neuronal responses support a role for orbitofrontal cortex in cognitive set reconfiguration
Authors: Sleezer Brianna J. , Loconte Giuliana , Castagno Meghan D. , Hayden Benjamin Y. 
Published: October 2016

ABSTRACTWe are often faced with the need to abandon no-longer beneficial rules and adopt new ones. This process, known as cognitive set reconfiguration, is a hallmark of executive control. Although cognitive functions like reconfiguration are most often associated with dorsal prefrontal structures, recent evidence suggests that the orbitofrontal cortex (OFC) may play an important role as well. We recorded activity of OFC neurons while rhesus macaques performed a version of the Wisconsin Card Sorting Task that involved a trial-and-error stage. OFC neurons demonstrated two types of switch-related activity, an early (switch-away) signal and a late (switch-to) signal, when the new task set was established. We also found a pattern ofmatch modulation: a significant change in activity for the stimulus that matched the current rule (and would therefore be selected). These results extend our understanding of the executive functions of the OFC. They also allow us to directly compare OFC with complementary datasets we previously collected in ventral (VS) and dorsal (DS) striatum. Although both effects are observed in all three areas, the timing of responses aligns OFC more closely with DS than with VS.
A Computational Model of Perceptual and Mnemonic Deficits in Medial Temporal Lobe Amnesia
Authors: Sadil Patrick S. , Cowell Rosemary A. 
Published: October 2016

AbstractDamage to the Medial Temporal Lobe (MTL) has long been known to impair declarative memory and recent evidence suggests that it also impairs visual perception. A theory termed the representational-hierarchical account explains such impairments by assuming that MTL stores conjunctive representations of items and events, and that individuals with MTL damage must rely upon representations of simple visual features in posterior visual cortex, which are inadequate to support memory and perception under certain circumstances. One recent study of visual discrimination behavior revealed a surprising anti-perceptual learning effect in MTL-damaged individuals: with exposure to a set of visual stimuli, discrimination performance worsened rather than improved (Barense et al., 2012). We extend the representational-hierarchical account to explain this paradox by assuming that difficult visual discriminations are performed by comparing the relative ‘representational tunedness’ – or familiarity – of the to-be-discriminated items. Exposure to a set of highly similar stimuli entails repeated presentation of simple visual features, eventually rendering all feature representations maximally, and thus equally, familiar ― hence, they are inutile for solving the task. Discrimination performance in patients with MTL lesions is therefore impaired by stimulus exposure. Because the unique conjunctions represented in MTL do not occur repeatedly, healthy individuals are shielded from this perceptual interference. We simulate this mechanism with a neural network previously used to explain recognition memory, thereby providing a model that accounts for both mnemonic and perceptual deficits caused by MTL damage with a unified architecture and mechanism.
Robust mixture modeling reveals category-free selectivity in reward region neuronal ensembles
Authors: Blanchard Tommy C. , Piantadosi Steven T. , Hayden Benjamin Y. 
Published: October 2016

ABSTRACTClassification of neurons into clusters based on their response properties is an important tool for gaining insight into neural computations. However, it remains unclear to what extent neurons fall naturally into discrete functional categories. We developed a Bayesian method that models the tuning properties of neural populations as a mixture of multiple types of task-relevant response patterns. We applied this method to data from several cortical and striatal regions in economic choice tasks. In all cases, neurons fell into only two clusters: one mixed-selectivity cluster containing all task-sensitive cells and another of no selectivity (i.e. pure noise) cells. The single cluster of task-sensitive cells argues against robust categorical tuning in these areas. The no selectivity cells were unanticipated; their identification allows for improved measurement of ensemble effects. Our findings provide a valuable tool for analysis of neural data and place strong constraints on neurocomputational models of choice and control.
Inference of multiple-wave population admixture by modeling decay of linkage disequilibrium with polynomial functions
Authors: Zhou Ying , Yuan Kai , Yu Yaoliang , Ni Xumin , Xie Pengtao , Xing Eric P , Xu Shuhua 
Published: October 2016

AbstractTo infer the histories of population admixture, one important challenge with methods based on the admixture linkage disequilibrium (ALD) is to get rid of the effect of source LD (SLD) which is directly inherited from source populations. In previous methods, only the decay curve of weighted LD between pairs of sites whose genetic distance were larger than a certain starting distance was fitted by single or multiple exponential functions, for the inference of recent single- or multiple-wave of admixture. However, the effect of SLD has not been well defined and no tool has been developed to estimate the effect of SLD on weighted LD decay. In this study, we defined the SLD in the formularized weighted LD statistic under the two-way admixture model, and proposed polynomial spectrum (p-spectrum) to study the weighted SLD and weighted LD. We also found reference populations could be used to reduce the SLD in weighted LD statistic. We further developed a method, iMAAPs, to inferMultiple-waveAdmixture by fittingALD usingPolynomialspectrum. We evaluated the performance of iMAAPs under various admixture models in simulated data and applied iMAAPs into analysis of genome-wide single nucleotide polymorphism data from the Human Genome Diversity Project (HGDP) and the HapMap Project. We showed that iMAAPs is a considerable improvement over other current methods and further facilitates the inference of the histories of complex population admixtures.
High-risk human papillomavirus in oral cavity squamous cell carcinoma
Authors: Palve Vinayak , Bagwan Jamir , Krishnan Neeraja M , Pareek Manisha , Chandola Udita , Suresh Amritha , Siddappa Gangotri , James Bonney L , Kekatpure Vikram , Kuriakose Moni Abraham , Panda Binay 
Published: October 2016

ABSTRACTPurposeThe prevalence of human papillomavirus (HPV) in oral cavity squamous cell carcinoma (OSCC) varies significantly based on assay sensitivity and patient geography. Accurate detection is essential to understand the role of HPV in disease prognosis and management of patients with OSCC.MethodsWe generated and integrated data from multiple analytes (HPV DNA, HPV RNA, and p16), assays (immunohistochemistry, PCR, qPCR and digital PCR) and molecular changes (somatic mutations and DNA methylation) from 153 OSCC patients to correlate p16 expression, HPV DNA, and HPV RNA with HPV incidence and patient survival.ResultsHigh prevalence (33-58%) of HPV16/18 DNA did not correlate with the presence of transcriptionally active viral genomes (15%) in tumors. Eighteen percent of the tumors were p16 positive. and only 6% were both HPV DNA and RNA positive. Most tumors with relatively high-copy HPV DNA, and/or HPV RNA, but not with HPV DNA alone (irrespective of copy number), were wild-type forTP53andCASP8genes. In our study, p16 protein, HPV DNA and HPV RNA, either alone or in combinations, did not correlate with patient survival. Nine HPV-associated genes stratified the virus +ve from the –ve tumor group with high confidence (p<0.008) when HPV DNA copy number and/or HPV RNA were considered to define HPV positivity and not HPV DNA alone irrespective of their copy number (p< 0.2).ConclusionsIn OSCC, the presence of both HPV RNA and p16 are rare. HPV DNA alone is not an accurate measure of HPV positivity and therefore not informative. Moreover, HPV DNA, RNA or p16 don’t correlate with outcome.
Cooperation not competition: bihemispheric tDCS and fMRI show role for ipsilateral hemisphere in motor learning
Authors: Waters Sheena , Wiestler Tobias , Diedrichsen Jörn 
Published: October 2016

AbstractWhat is the role of ipsilateral motor and pre-motor areas in motor learning? One view supposes that ipsilateral activity suppresses contralateral motor cortex, and thus needs to be inhibited to improve motor learning. Alternatively, the ipsilateral motor cortex may play an active role in the control and learning of unilateral hand movements. We approached this question by applying double-blind bihemispheric transcranial direct current stimulation (tDCS) over both contralateral and ipsilateral motor cortex in a between-group design during four days of unimanual explicit sequence training. Independently of whether the anode was placed over contralateral or ipsilateral motor cortex, bihemispheric stimulation yielded substantial performance gains relative to unihemispheric or sham stimulation. This performance advantage appeared to be supported by plastic changes in both hemispheres: First, we found that behavioral advantages generalized strongly to the untrained hand, suggesting that tDCS strengthened effector-independent representations. Secondly, functional imaging during speed-matched execution of trained sequences conducted 48 h after training revealed sustained, polarity-independent increases in activity in both motor cortices relative to the sham group. These results suggest a cooperative rather than competitive interaction of the two motor cortices during skill learning and suggest that bihemispheric brain stimulation during unimanual skill learning may be beneficial, because it harnesses plasticity in the ipsilateral hemisphere.Significance statementMany neurorehabilitation approaches are based on the idea that is beneficial to boost excitability in the contralateral hemisphere while attenuating that of the ipsilateral cortex to reduce interhemispheric inhibition. We observed that bihemispheric tDCS with the excitatory anode either over contralateral or ipsilateral motor cortex facilitated motor learning nearly twice as strongly as unihemispheric tDCS. These increases in motor learning were accompanied by increases in fMRI activation in both motor cortices that outlasted the stimulation period, as well as increased generalization to the untrained hand. Collectively, our findings suggest a cooperative—rather than competitive—role of the hemispheres and imply that it is most beneficial to harness plasticity in both hemispheres in neurorehabilitation of motor deficits.
Distinct oscillatory frequencies underlie excitability of human occipital and parietal cortex
Authors: Samaha Jason , Gosseries Olivia , Postle Bradley R. 
Published: October 2016

AbstractMagnetic stimulation (TMS) of human occipital and posterior parietal cortex can give rise to visual sensations called phosphenes, but neural correlates of phosphene perception preceding and succeeding stimulation of both areas are unknown. Using near-threshold TMS with concurrent electroencephalography (EEG) recordings, we uncover oscillatory brain dynamics that covary, on single trials, with the perception of phosphenes following occipital and parietal TMS. Prestimulus power and phase predominantly in the alpha-band (8-13 Hz) predicted occipital TMS phosphenes, whereas higher frequency beta-band (13-20 Hz) power (but not phase) predicted parietal TMS phosphenes. TMSevokedresponses related to phosphene perception were similar across stimulation sites and were characterized by an early (200 ms) posterior negativity and a later (>300 ms) parietal positivity in the time domain and an increase in low-frequency (~5-7 Hz) power followed by a broadband decrease in alpha/beta power in the time-frequency domain. These correlates of phosphene perception closely resemble known electrophysiological correlates of conscious perception using near-threshold visual stimuli and speak to the possible early onset of visual consciousness. The differential pattern of prestimulus predictors of phosphene perception suggest that distinct frequencies reflect cortical excitability within different cortical regions, and that the alpha-band rhythm, long thought of as a general index of cortical inhibition, may not reflect excitability of posterior parietal cortex.Significance statementAlpha-band oscillations are thought to reflect cortical excitability and are therefor suggested to play an important role in gating information transmission across cortex. We directly probe cortical excitability in human occipital and parietal cortex and observed that whereas alpha-band dynamics indeed reflect excitability of occipital areas, beta-band activity was most predictive of parietal cortex excitability. Differences in the state of cortical excitability predicted perceptual outcomes, which were manifest in both early and late patterns of evoked activity, shedding light on the neural correlates of consciousness. Our findings prompt revision of the notion that alpha activity reflects inhibition across all of cortex and suggests instead that excitability in different regions is reflected in distinct frequency bands.
Being a guest – perspectives of an extended hospitality approach
Authors: Pechlaner Harald , Nordhorn Christian , Poppe Xenia 
Published: October 2016

Purpose
This paper aims to deduce and present an extended hospitality approach. In developed countries, hospitality is increasingly linked to tourism; in times of migration and increased refugee flows, the accompanying social, economic and political determining factors play a more prominent role, necessitating a new view of hospitality. This study aims to extend the domain of tourism in hospitality by including aspects related to asylum seekers and to combine it with topics regarding welcome culture, service quality and relational quality. The paper explores the question concerning whether, and in which ways, the various sectors may learn from each other.

Design/methodology/approach
To expand this new research area and to take the exploratory nature of the research aim into consideration, a qualitative approach was chosen. Fourteen qualitative interviews with experts from the tourism and industry sectors and organizations linked with asylum seekers were conducted; the interviewees were chosen by purposeful sampling, according to knowledge and diversity criteria. GABEK was used as a qualitative research strategy, which involves theories of a phenomenological and linguistic nature. This method allows for a more holistic approach to the complex nature of the topic through the collection of perceptions resulting from open qualitative interviews and a keyword-based analysis.

Findings
The paper presents a model for an extended hospitality approach, as hospitality should not be limited to its connection with tourism matters. Refugees as well as tourists rely on the friendliness and the welcoming nature (hereafter: “welcome culture”) of a host country. The tourism industry can stand to improve its unconditional hospitality toward refugees — the comprehension and understanding of different cultures and values is an important aspect of welcoming new arrivals in the local surroundings, be they tourists, migrants or refugees.

Research limitations/implications
As stated above, a qualitative research approach was chosen with the intent to open the research field toward an extended hospitality approach. Therefore, future research must focus on testing the results for application in a more general context. The study was also limited insofar as the conduction of research took place in Bavaria alone.

Practical implications
As stated above, a qualitative research approach was chosen with the intent to open the research field toward an extended hospitality approach. Therefore, future research must focus on testing the results for application in a more general context. The study was also limited insofar as the conduction of research took place in Bavaria alone.

Originality/value
This paper combines different access points to hospitality in a new form.
Connecting curriculum, capabilities and careers
Authors: Thomas Ian , Depasquale James 
Published: October 2016

PurposeThe reported research aims to examine the extent to which sustainability capabilities have been delivered by a specific example of Education for Sustainability (EfS) and Education for Sustainable Development (ESD), and how important the capabilities have been in the workplace.Design/methodology/approachStudents who participated in an undergraduate internationally based research project were electronically surveyed. Questions sought responses related to demographics, the relevance of five “sustainability competencies” to the participant’s employment, the degree to which the five competencies had been developed within the students’ project and capabilities participants felt were important to their careers.FindingsClearly supported was the relevance of all five sustainability competencies, especially that of “interpersonal competence”.Practical implicationsA problem-based learning (PBL) design guided the students’ project and the findings indicate that these designs can be effective in delivering the five capabilities discussed. Interpersonal capability appears to be strongly developed, probably because PBL typically involves teamwork, often across disciplines. Nonetheless, those running these PBL-based subjects could note that careful design may be needed to ensure the development of systems thinking, anticipatory and normative capabilities. Also, the five competencies provide a reasonably good guide for what is important in the workplace and for designing learning experiences.Originality/valueClarification of competencies valued in the workplace provides guidance for the design of higher education curricular so that graduates become effective sustainability professionals.