bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfusion MRI-based differentiation between early tumor progression and pseudoprogression in glioblastoma and its use in clinical practice
Authors: van Dorth Daniëlle , Croese Robert J I , Jiang Feng Yan , Schmitz-Abecassis Bárbara , Taphoorn Martin J B , Smits Marion , Dirven Linda , van Osch Matthias J P , de Bresser Jeroen , Koekkoek Johan A F 
Published: October 2024

Abstract

Background
Early treatment effects in patients with glioblastoma are frequently discussed during multidisciplinary team meetings (MDTM), after which a decision regarding (dis)continuation of tumor-targeted treatment is made. This study examined whether a separate and systematic evaluation of perfusion MRI (pMRI) could impact such treatment decisions in the early stage.

Methods
This retrospective observational study evaluated the diagnostic accuracy for detecting early tumor progression of 4 different approaches including conventional MRI, pMRI with Arterial Spin Labeling (ASL), and/or Dynamic Susceptibility Contrast (DSC) MRI, and compared those to the MDTM evaluation in clinical practice.

Results
Sixty-five glioblastoma patients with clinical and radiological data until 9 months after irradiation were included. For all approaches, the sensitivity for detecting early true disease progression was poor to moderate (32%–62%). Area under the curve values were comparable (range 0.63–0.74), but highest for the MDTM evaluation (0.74). In the cases of inconclusive MDTM (26%), systematic pMRI evaluation showed a higher sensitivity compared to conventional MRI (respectively, 36% vs 0%), while the specificity was 100% for all MRI approaches. Multivariable regression analysis showed that a lower KPS score (OR = 0.84 [95% CI: 0.77–0.91]) and pMRI indicative of tumor progression (OR = 0.09 [95% CI: 0.02–0.52]) were independently associated with concluding tumor progression at the MDTM.

Conclusion
MDTM assessment in daily clinical practice has a higher diagnostic accuracy in distinguishing early tumor progression from pseudoprogression compared to a separate, systematic evaluation of pMRI. Systematic evaluation of pMRI might be helpful if the clinical MDTM assessment is uncertain.
Variation in Relative Risk Perceptions and Tobacco Use by Race and Socioeconomic Status Among Older Adults Who Smoke: Evidence From the Population Assessment of Tobacco and Health Study
Authors: Snell L Morgan , Barnes Andrew J , Eissenberg Thomas 
Published: October 2024

Abstract

Introduction
Older adults who smoke face significant risk of tobacco-related diseases and hold misperceptions about health risks posed by nicotine product use. This study examined whether socioeconomic status (SES) and race are associated with variation in cigarette/e-cigarette relative risk perceptions, whether relative risk perceptions are associated with tobacco use behaviors, and whether SES and race moderate associations between perceptions and use behaviors.

Methods
Five waves of Population Assessment of Tobacco and Health (PATH) Study yielded data from 1879 adults aged 55 years and older who smoked within the past 30 days during Wave 1. Adjusted longitudinal logistic models estimated associations between higher versus lower SES (“low SES”: less than high school diploma/GED and annual household income &lt;$25 000) and race (White vs. Black/African American [AA]) and e-cigarette/cigarette relative risk perceptions, behavioral intentions, and e-cigarette use.

Results
Lower-SES adults were more likely to report that e-cigarettes were very/extremely harmful to health (adjusted OR [AOR]: 1.74, p &lt; .01) and less likely to report that e-cigarettes were less harmful than cigarettes (AOR: 0.65, p &lt; .01). Black/AA adults were less likely to report that e-cigarettes were less harmful than cigarettes. Participants rating e-cigarettes as equally/more harmful than cigarettes exhibited lower odds of intending to quit smoking or switch to e-cigarettes. Finally, Black/AA adults who also perceived e-cigarettes equally/more harmful than cigarettes exhibited greater odds of trying to reduce rather than quit smoking (AOR: 1.58, p = .02).

Conclusions
Many older adults who smoke perceive e-cigarettes as equally or more harmful than cigarettes, particularly low-SES and Black/AA older adults. Differences in relative risk perceptions among high-priority populations could negatively influence cessation attempts and switching behaviors.

Implications
This study found that Black/AA and low-SES older adults who smoke cigarettes were more likely to perceive e-cigarettes as harmful or more harmful than cigarettes. The absence of accurate, evidence-based information regarding the relative health risks associated with the long-term use of various tobacco products may impede policy efforts to reduce disparities in smoking-related disease through increased cessation and/or harm reduction.
Chemotherapy-induced cognitive impairment and its long-term development in patients with breast cancer: results from the observational CICARO study
Authors: Kerkmann Anna , Schinke Christian , Dordevic Adam , Kern Johannes , Bangemann Nikola , Finck Josefine , Blohmer Jens-Uwe , Ruprecht Klemens , Göpfert Jens C , Otto Carolin , Materne Bianca , Endres Matthias , Boehmerle Wolfgang , Huehnchen Petra 
Published: October 2024

Abstract

Background
Chemotherapy-induced cognitive impairment (CICI) is a well-recognized side effect of breast cancer treatment. However, prospective long-term evaluations of CICI using standardized neuropsychological tests are scarce.

Patients and Methods
This prospective longitudinal cohort study investigated cognitive dysfunction and its impact on quality of life and everyday functioning in patients with breast cancer receiving first-line chemotherapy compared to patients with breast cancer without chemotherapy. Assessment occurred prior to chemotherapy, postchemotherapy (median 6 months), and 2-3 years later. We used standardized neuropsychological tests, questionnaires, and scales to assess patients’ quality of life and functioning. Additionally, serum analysis for neurodegenerative markers and autoantibodies was conducted.

Results
We included n = 53 patients. Overall cognitive function declined statistically significantly (P = .046) postchemotherapy compared to control patients, mostly driven by a reduced figural memory (P = .011). Patients who received chemotherapy showed a greater reduction in quality of life (increased fatigue symptoms, P = .023; reduced Karnofsky index, P &lt; .001); however, without a statistically significant effect on cognitive decline. The neurodegenerative markers Neurofilament light chain (NfL) and phosphorylated Neurofilament heavy chain (pNfH) increased statistically significantly (P &lt; .001) postchemotherapy and pNfH correlated with overall cognitive function. After 2-3 years, both cognitive performance and quality of life were comparable between chemotherapy-treated and control patients.

Conclusion
Our findings suggest that chemotherapy statistically significantly contributes to overall cognitive dysfunction in patients with breast cancer, which disappears after 2-3 years, indicating a recovery in both objectively measurable cognitive function and subjective quality of life. Future research should examine larger sample sizes and explore screening indicators, particularly pNfH.
An mRNA methylase and demethylase regulate sorghum salt tolerance by mediating N6-methyladenosine modification
Authors: Zheng Hongxiang , Dang Yingying , Gao Yinping , Li Simin , Wu FengHui , Zhang Fangning , Wang Xuemei , Du Xihua , Wang Lei , Song Jie , Sui Na 
Published: October 2024

Abstract
N 6-methyladenosine (m6A) modification is a crucial and widespread molecular mechanism governing plant development and stress tolerance. The specific impact of m6A regulation on plants with inherently high salt tolerance remains unclear. Existing research primarily focuses on the overexpression or knockout of individual writer or eraser components to alter m6A levels. However, a comprehensive study simultaneously altering overall m6A modification levels within the same experiment is lacking. Such an investigation is essential to determine whether opposing changes in m6A modification levels exert entirely different effects on plant salt tolerance. In this study, we identified the major writer member mRNA adenosine methylase A (SbMTA) in sorghum (Sorghum bicolor) as critical for sorghum survival. The sbmta mutant exhibits a phenotype characterized by reduced overall m6A, developmental arrest, and, ultimately, lethality. Overexpression of SbMTA increased m6A levels and salt tolerance, while overexpression of the m6A eraser alkylated DNA repair protein AlkB homolog 10B (SbALKBH10B) in sorghum showed the opposite phenotype. Comparative analyses between sorghum with different m6A levels reveal that SbMTA- and SbALKBH10B-mediated m6A alterations significantly impact the stability and expression levels of genes related to the abscisic acid signaling pathway and growth under salt stress. In summary, this study unveils the intricate relationship between m6A modifications and salt tolerance in sorghum, providing valuable insights into how m6A modification levels on specific transcripts influence responses to salt stress.
OsPUB75–OsHDA716 mediates deactivation and degradation of OsbZIP46 to negatively regulate drought tolerance in rice
Authors: Sun Ying , Gu Xinyue , Qu Chengfeng , Jin Ning , Qin Tian , Jin Liang , Huang Junli 
Published: October 2024

Abstract
Histone deacetylases (HDACs) play crucial roles in plant stress responses via modification of histone as well as nonhistone proteins; however, how HDAC-mediated deacetylation of nonhistone substrates affects protein functions remains elusive. Here, we report that the reduced potassium dependency3/histone deacetylase1–type histone deacetylase OsHDA716 and plant U-box E3 ubiquitin ligase OsPUB75 form a complex to regulate rice drought response via deactivation and degradation of basic leucine zipper (bZIP) transcription factor OsbZIP46 in rice (Oryza sativa). OsHDA716 decreases abscisic acid (ABA)-induced drought tolerance, and mechanistic investigations showed that OsHDA716 interacts with and deacetylates OsbZIP46, a key regulator in ABA signaling and drought response, thus inhibiting its transcriptional activity. Furthermore, OsHDA716 recruits OsPUB75 to facilitate ubiquitination and degradation of deacetylated OsbZIP46. Therefore, the OsPUB75–OsHDA716 complex exerts double restrictions on the transcriptional activity and protein stability of OsbZIP46, leading to repression of downstream drought-responsive gene expression and consequently resulting in reduced drought tolerance. Conversely, OsbZIP46 acts as an upstream repressor to repress OsHDA716 expression, and therefore OsHDA716 and OsbZIP46 form an antagonistic pair to reciprocally inhibit each other. Genetic evidence showed that OsHDA716 works with OsbZIP46 in a common pathway to antagonistically regulate rice drought response, revealing that plants can fine-tune stress responses by the complex interplay between chromatin regulators and transcription factors. Our findings unveil an acetylation-dependent regulatory mechanism governing protein functions and shed light on the precise coordination of activity and stability of key transcription factors through a combination of different posttranslational modifications.
Explanations of and interventions against affective polarization cannot afford to ignore the power of ingroup norm perception
Authors: You Zi Ting , Lee Spike W S 
Published: October 2024

Abstract
Affective polarization, or animosity toward opposing political groups, is a fundamentally intergroup phenomenon. Yet, prevailing explanations of it and interventions against it have overlooked the power of ingroup norm perception. To illustrate this power, we begin with evidence from 3 studies which reveal that partisans' perception of their ingroup's norm of negative attitudes toward the outgroup is exaggerated and uniquely predicts their own polarization-related attitudes. Specifically, our original data show that in predicting affective polarization (i.e. how one feels about one's partisan outgroup), the variance explained by ingroup norm perception is 8.4 times the variance explained by outgroup meta-perception. Our reanalysis of existing data shows that in predicting support for partisan violence (i.e. how strongly one endorses and is willing to engage in partisan violence), ingroup norm perception explains 52% of the variance, whereas outgroup meta-perception explains 0%. Our pilot experiment shows that correcting ingroup norm perception can reduce affective polarization. We elucidate the theoretical underpinnings of the unique psychological power of ingroup norm perception and related ingroup processes. Building on these empirical and theoretical analyses, we propose approaches to designing and evaluating interventions that leverage ingroup norm perception to curb affective polarization. We specify critical boundary conditions that deserve prioritized attention in future intervention research. In sum, scientists and practitioners cannot afford to ignore the power of ingroup norm perception in explaining and curbing affective polarization.
Moral wiggle room and group favoritism among political partisans
Authors: Robbett Andrea , Walsh Henry , Matthews Peter Hans 
Published: October 2024

Abstract
How does the availability of excuses for self-interested behavior impact group favoritism? We report the results of a preregistered experiment, conducted on the eve of the 2022 midterm elections, in which American political partisans made payoff distribution choices for themselves and a partner who was known to be a co-partisan or opposing partisan. Under full information, participants exhibit significant group favoritism. However, when the payoff consequences for one's partner are initially hidden, participants exploit this excuse to act selfishly regardless of who their partner is and ignorance rates are identical for in-group and out-group members. As a result, moral wiggle room has a significantly larger impact on selfish behavior for those interacting with co-partisans than opposing partisans, leading to a reduction in group favoritism.
Affective polarization is uniformly distributed across American States
Authors: Holliday Derek E , Lelkes Yphtach , Westwood Sean J 
Published: October 2024

Abstract
US partisans view each other with increasing negativity. While many attribute the growth of such affective polarization to nationally cross-cutting forces, such as ideological partisan sorting or access to partisan media, others emphasize the effects of contextual and institutional forces. For the first time, we introduce and explore data sufficiently granular to fully map the extent of partisan animosity across the US states. With a massive, nationally representative survey we find that, counter to expectations, variation in affective polarization across states is relatively small, and is instead largely a function of individual-level attitudinal (but not demographic) characteristics. While elections pit regions of the country against others, our results suggest affective polarization is a national, not regional, problem, requiring national interventions.
Understanding reaction to corporate activism: The moderating role of polarization
Authors: Braga Luiza , Grinstein Amir , Tardin Matheus , Perin Marcelo 
Published: October 2024

Abstract
In our polarized societies, more companies are taking a stand on divisive sociopolitical issues. However, given the mixed findings from previous studies, it remains unclear whether Corporate Activism (CA) is more likely to hurt or help a company's performance and reputation, or shape the public's attitudes toward the sociopolitical issue involved. To better understand the impact of CA in polarized societies, it is valuable to study moderating factors, especially those linked to polarization. A meta-analysis of 72 scholarly works is conducted to examine the impact of CA on various outcomes (e.g. ads and social media engagement, cognitive and attitudinal reactions, public's intentions and actions, emotional reactions, social and ethical engagement, workplace, and employee perceptions) and the role of moderators (a sociopolitical issue's political leaning and controversy level, political orientation of the target audience, key demographics). The analysis reveals a positive, albeit small, effect size (0.085 [95% CI (0.0542, 0.1158)]) with the most impact on two outcomes: cognitive and attitudinal reactions, and emotional reactions. It further reveals that companies adopting liberal-leaning CAs elicit more favorable responses than those adopting conservative CAs and that liberals respond positively to CA, while conservatives are more neutral. However, when there is alignment between the CA's political leaning and the audience's political orientation, conservatives have a stronger positive response than liberals. Also, younger audiences view CA more positively. Finally, per national culture, while power distance and individualism positively moderate the reaction to CA, uncertainty avoidance has a negative effect.
Critical thinking and misinformation vulnerability: Experimental evidence from Colombia
Authors: List John A , Ramirez Lina M , Seither Julia , Unda Jaime , Vallejo Beatriz H 
Published: October 2024

Abstract
Misinformation represents a vital threat to the societal fabric of modern economies. While skills interventions to detect misinformation such as de-bunking and prebunking, media literacy, and manipulation resilience have begun to receive increased attention, evidence on de-biasing interventions and their link with misinformation vulnerability is scarce. We explore the demand for misinformation through the lens of augmenting critical thinking in an online framed field experiment during the 2022 Presidential election in Colombia. Data from roughly 2.000 individuals suggest that providing individuals with information about their own biases (obtained through a personality test) has no impact on skepticism towards news. But (additionally) showing participants a de-biasing video seems to enhance critical thinking, causing subjects to more carefully consider the truthfulness of potential misinformation.
From the inside out: Were the cuticular Pseudonocardia bacteria of fungus-farming ants originally domesticated as gut symbionts?
Authors: Innocent Tabitha M , Sapountzis Panagiotis , Zhukova Mariya , Poulsen Michael , Schiøtt Morten , Nash David R , Boomsma Jacobus J 
Published: October 2024

Abstract
The mutualistic interaction specificity between attine ants and antibiotic-producing Actinobacteria has been controversial because Pseudonocardia strains cannot always be isolated from worker cuticles across attine ant species, while other actinobacteria can apparently replace Pseudonocardia and also inhibit growth of Escovopsis mycopathogens. Here we report that across field samples of Panamanian species: (i) Cuticular Pseudonocardia were largely restricted to species in the crown of the attine phylogeny and their appearance likely coincided with the first attines colonizing Central/North America. (ii) The phylogenetically basal attines almost always had cuticular associations with other Actinobacteria than Pseudonocardia. (iii) The sub-cuticular glands nourishing cuticular bacteria appear to be homologous throughout the phylogeny, consistent with an ancient general attine-Actinobacteria association. (iv) The basal attine species investigated always had Pseudonocardia as gut symbionts while Pseudonocardia presence appeared mutually exclusive between cuticular and gut microbiomes. (v) Gut-associated Pseudonocardia were phylogenetically ancestral while cuticular symbionts formed a derived crown group within the Pseudonocardia phylogeny. We further show that laboratory colonies often secondarily acquire cuticular Actinobacteria that they do not associate with in the field, suggesting that many previous studies were uninformative for questions of co-adaptation in the wild. An exhaustive literature survey showed that published studies concur with our present results, provided that they analyzed field colonies and that Actinobacteria were specifically isolated from worker cuticles shortly after field collection. Our results offer several testable hypotheses for a better overall understanding of attine-Pseudonocardia interaction dynamics and putative coevolution throughout the Americas.
Positive beliefs about cross-partisan empathy can strengthen Americans’ support for democracy
Authors: Santos Luiza A , Voelkel Jan G , Willer Robb , Zaki Jamil 
Published: October 2024

Abstract
Undemocratic practices, such as voter suppression and election interference, threaten democracies worldwide. Across four studies (N = 4,350), we find that informational and motivational factors drive Americans’ support for such practices. Partisans drastically overestimate how much opponents support undemocratic practices, which decreases people's willingness to defend democracy themselves (S1–S2). One remedy for this dynamic is to inform people about the extent to which their rivals actually support democracy, but in polarized contexts, people are incurious about the true beliefs of outpartisans. To address this, we test a new method for improving democratic attitudes—changing beliefs about cross-party empathy. Empathizing across disagreements can improve connections and boost persuasion. When people learn about these valued consequences of empathic engagement, their curiosity about outpartisans increases (S3), and they choose to learn about opponents’ support for democracy, which reduces their own support for undemocratic practices and politicians (S4). Our findings suggest that fostering support for democracy requires not just informational strategies but also motivational ones. The power of our combined approach comes in that—instead of presenting people with information about outpartisans—it induces them to seek out that information themselves. Together, these results highlight how cross-party empathy beliefs can increase people's curiosity about those they disagree with and disrupt processes of political escalation.
Toward building deliberative digital media: From subversion to consensus
Authors: Pentland Alex , Tsai Lily 
Published: October 2024

Abstract
Evidence-based and human-centric design of digital media platforms could reduce many of the problems of misinformation, polarization, and misaligned incentives that plague both society and individual organizations. With these sorts of design changes, it may become possible to build deliberative digital media that are useful both for discussions of contentious issues and for achieving successful collective action. In this Perspective paper, we discuss several issues in which current-day social science indicates the origin of these problems and suggests methods for improvement. Finally, we analyze a popular deliberative democracy platform to illustrate how social science might enable design of next-generation digital media suitable for democratic deliberation, and in which generative artificial intelligence might be useful.