bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology
Authors: Gesenhues Jonas , Hein Marc , Ketelhut Maike , Habigt Moriz , Rüschen Daniel , Mechelinck Mare , Albin Thivaharan , Leonhardt Steffen , Schmitz-Rode Thomas , Rossaint Rolf , Autschbach Rüdiger , Abel Dirk 
Published: January 2017

AbstractComputational models of biophysical systems generally constitute an essential component in the realization of smart biomedical technological applications. Typically, the development process of such models is characterized by a great extent of collaboration between different interdisciplinary parties. Furthermore, due to the fact that many underlying mechanisms and the necessary degree of abstraction of biophysical system models are unknown beforehand, the steps of the development process of the application are iteratively repeated when the model is refined. This paper presents some methods and tools to facilitate the development process. First, the principle of object-oriented (OO) modeling is presented and the advantages over classical signal-oriented modeling are emphasized. Second, our self-developed simulation tool ModeliChart is presented. ModeliChart was designed specifically for clinical users and allows independently performing
Physiological closed-loop control of mechanical ventilation and extracorporeal membrane oxygenation
Authors: Brendle Christian , Mülders Thorsten , Kühn Jan , Janisch Thorsten , Kopp Rüdger , Rossaint Rolf , Stollenwerk Andre , Kowalewski Stefan , Misgeld Berno , Leonhardt Steffen , Walter Marian 
Published: January 2017

AbstractA new concept is presented for cooperative automation of mechanical ventilation and extracorporeal membrane oxygenation (ECMO) therapy for treatment of acute respiratory distress syndrome (ARDS). While mechanical ventilation is continuously optimized to promote lung protection, extracorporeal gas transfer rates are simultaneously adjusted to control oxygen supply and carbon dioxide removal using a robust patient-in-the-loop control system. In addition, the cooperative therapy management uses higher-level algorithms to adjust both therapeutic approaches. The controller synthesis is derived based on the introduced objectives, the experimental setup and the uncertain models. Finally, the autonomous ARDS therapy system capabilities are demonstrated and discussed based on
Influence of surface roughness of dental zirconia implants on their mechanical stability, cell behavior and osseointegration
Authors: Strickstrock Monika , Rothe Holger , Grohmann Steffi , Hildebrand Gerhard , Zylla Isabella M. , Liefeith Klaus 
Published: January 2017

AbstractIt is generally accepted that a micrometer scale roughness supports the osseointegration of titanium implants. While abrasive technologies can easily be employed to create a micro-topography on titanium surfaces, the preparation of rough ceramic surfaces is more challenging. Typically, abrasive treatments of yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) surfaces result in rather smooth topographies (R
Application of photocatalytic paint for destruction of benzo[a]pyrene. Impact of air humidity
Authors: Homa Piotr , Tryba Beata 
Published: January 2017

AbstractLatex (LX) paint was tested for photocatalytic decomposition of benzo[a]pyrene (BaP) under different conditions of relative humidity (RH), temperature and irradiation. Porcelain trays coated with LX paint were loaded with BaP solution, which was dissolved in acetonitrile. Trays were placed inside the photoreactor and irradiated with UV or a fluorescent lamp. Different conditions of RH and temperature inside the photoreactor were used. BaP preliminarily adsorbed on LX paint surface was decomposed faster at higher temperature and lower RH. For example, at 42 °C and RH 20 % BaP decomposition rate reached 64 %. At same temperature and with RH of 80 % this rate decreased to only 42 %. It was also demonstrated that at high RH (80 %) and under UV irradiation water contact angle on the paint surface was decreasing at a lower rate than under RH of 20 %. It was also proven that BaP could be sufficiently decomposed under irradiation by fluorescent lamp (59 % in comparison to 64 % under same environmental conditions with use of UV light). However, its decomposition rate was approximately 5 times slower than under UV light
Investigation of antinociceptive activity of methanolic extract of Persicaria orientalis leaves in rodents
Authors: Ansari Prawej , Uddin Md. Josim , Akther Shafia , Azam Shofiul , Mahmud Md Kayes , Azad Sohel Bin , Ullah Ahsan , Hannan J.M.A. 
Published: January 2017

Abstract

Background:
This study aims to evaluate the scientific basis of traditional application of Persicaria orientalis for reducing pain and inflammation.

Methods:
An in vitro method was performed to investigate the presence of the anti-inflammatory activity of methanolic crude extract of P. orientalis. In addition, an in vivo study was conducted in which the hot-plate and tail immersion methods were applied to explore the acute effect of P. orientalis on analgesia. The potency to inhibit chronic inflammation in mice was justified by the carrageenan-induced paw edema and formalin-induced edema methods. For all in vivo testing in animal models (albino mice and rats), plant extract was given via the oral route at doses of 250 mg/kg and 500 mg/kg.

Results:
The methanolic extract of P. orientalis produced a significant (p<0.001) inhibition of analgesia with a prolongation of pain response time by 61.80% at 500 mg/kg. The extract also exhibited a potential anti-inflammatory (56.99%) effect, which was also statistically significant (p<0.001). The present study suggests that the methanolic extract of P. orientalis has potential anti-inflammatory as well as analgesic activity and this extract is effective in the treatment of both acute and chronic pain.

Conclusions:
Our current study revealed pharmacological properties of the methanolic extract of P. orientalis and also gave a solid scientific platform against its traditional use. The protecting ability of P. orientalis against inflammatory stimuli may be due to phenolic or flavonoid compounds which we have found through phytochemical analysis.
Fabricating waveguide Bragg gratings (WBGs) in bulk materials using ultrashort laser pulses
Authors: Ams Martin , Dekker Peter , Gross Simon , Withford Michael J. 
Published: January 2017

Abstract
Optical waveguide Bragg gratings (WBGs) can be created in transparent materials using femtosecond laser pulses. The technique is conducted without the need for lithography, ion-beam fabrication methods, or clean room facilities. This paper reviews the field of ultrafast laser-inscribed WBGs since its inception, with a particular focus on fabrication techniques, WBG characteristics, WBG types, and WBG applications.
Recent progress in asymmetric synthesis of aminophosphonic acids mediated by chiral sulfinyl auxiliary
Authors: Mikołajczyk Marian , Łyżwa Piotr 
Published: January 2017

Abstract
This account outlines the recent results on our strategy of the diastereoselective asymmetric synthesis of aminophosphonic acids (APs) using enantiomeric sulfinimines as chirality inducing reagents. Three important topics are discussed: (a) application of a double asymmetric induction in the synthesis of enantiomerically pure APs; (b) development of a general approach to the synthesis of γ-aminophosphonic acids (γ-APs) and (c) the use enantiomeric N-(p-tolylsulfinyl)cinnamaldimines in the synthesis of diverse α- and β-aminophosphonic acids (AP3, AP4) including the first synthesis of (R)-phosphoemeriamine.
Effect of the Pore Size Distribution on the Displacement Efficiency of Multiphase Flow in Porous Media
Authors: Yang Yongfei , Liu Pengfei , Zhang Wenjie , Liu Zhihui , Sun Hai , Zhang Lei , Zhao Jianlin , Song Wenhui , Liu Lei , An Senyou , Yao Jun 
Published: January 2017

AbstractDue to the complexity of porous media, it is difficult to use traditional experimental methods to study the quantitative impact of the pore size distribution on multiphase flow. In this paper, the impact of two pore distribution function types for three-phase flow was quantitatively investigated based on a three-dimensional pore-scale network model. The results show that in the process of wetting phase displacing the non-wetting phase without wetting films or spreading layers, the displacement efficiency was enhanced with the increase of the two function distribution’s parameters, which are the power law exponent in the power law distribution and the average pore radius or standard deviation in the truncated normal distribution, and vice versa. Additionally, the formation of wetting film is better for the process of displacement.
Quasi-planar elemental clusters in pair interactions approximation
Authors: Chkhartishvili Levan 
Published: January 2017

Abstract
The pair-interactions approximation, when applied to describe elemental clusters, only takes into account bonding between neighboring atoms. According to this approach, isomers of wrapped forms of 2D clusters – nanotubular and fullerene-like structures – and truly 3D clusters, are generally expected to be more stable than their quasi-planar counterparts. This is because quasi-planar clusters contain more peripheral atoms with dangling bonds and, correspondingly, fewer atoms with saturated bonds. However, the differences in coordination numbers between central and peripheral atoms lead to the polarization of bonds. The related corrections to the molar binding energy can make small, quasi-planar clusters more stable than their 2D wrapped allotropes and 3D isomers. The present work provides a general theoretical frame for studying the relative stability of small elemental clusters within the pair interactions approximation.
Guarding the gate politically and politely: How accreditation teams do facework while gatekeeping
Authors: Ho Victor 
Published: January 2017

AbstractAccreditation is a quality assurance mechanism which evaluates either the capability of an institution to offer an academic program or the quality of an academic program before its launch. Accredited institutions and programs are allowed to enroll students, both fee-paying and non-fee-paying. The outcome of an accreditation exercise will therefore have significant implications for an institution’s reputation and finance. Institutions are normally informed of the outcome through an accreditation report, a genre whose discourse is intrinsically interesting and important, and thus deserves fuller research attention, for two reasons: (1) the genre contains evaluations and comments which can be negative and face-threatening, and (2) the accreditation team, as we can safely assume, will do facework subsequent to the performance of face threats through the negative evaluations and comments. The present study seeks to gain a better understanding of the lexicogrammar of this genre in general, and the lexicogrammar used to textualize facework in particular by analyzing the discourse of 30 accreditation reports in an Australian context. This paper argues that the evaluative language used in this genre can serve to perform facework for both the institution being accredited and the accreditation team itself, and have important implications for both the workplace and classroom.
Comparison of high sensitive and conventional troponin assays in diagnosis of acute myocardial infarction
Authors: Işıksaçan Nilgün , Bıyık İsmail , Ertürk Mehmet , Koşer Murat , Karakurt Hüseyin , Özalp Begüm , Baycan Ömer Faruk , Yıldırım Mehmet Rıfat , Yazan Serkan , Aktürk İbrahim Faruk 
Published: January 2017

Abstract

Introduction
We aimed to compare the positive predictive values (PPV) and negative predictive values (NPV) of four cardiac troponin assays in the diagnosis of AMI in Turkish population.

Methods
This study is an observational comparative study, which is performed between 2012 and 2013 (527 patients). Troponin levels were measured with chemiluminescence Cobas troponin T assay, immunofluorescence Triage troponin I assay and immunochromatographic Toyo troponin I assay.

Results
Sensitivity and specificity of immunofluorometric assay (Radiometer) are 56.82% and 71.34%; immunochromatographic assay (Toyo) are 29.4% and 88.62%, immunofluorescence assay (Triage) are 47.13% and 76.12%, chemiluminescence assay (Roche) are 60.49 and 67.42%, respectively. PPV, NPV and positive likelihood ratios (LR+) of immunofluorometric assay (Radiometer) are 45.5%, 79.7% and 1.98, immunochromatographic assay (Toyo) are 51.5%, 75.4% and 2.58, immunofluorescence assay (Triage) are 46.5%, 76.6% and 1.97, chemiluminescence assay (Roche) are 45.8%, 78.9% and 1.86, respectively. In four assays, troponin levels were statistically significant higher in AMI positive group in comparison to negative group (p<0.001 for all).

Conclusion
There was no statistically significant difference between these troponin methods in comparisons of PPV and NPV in the diagnosis of AMI, but low sensitivity of Triage and Toyo assays should be considered.
Rogue Waves and Hybrid Solutions of the Boussinesq Equation
Authors: Rao Ji-Guang , Liu Yao-Bin , Qian Chao , He Jing-Song 
Published: January 2017

Abstract
The rational and semirational solutions in the Boussinesq equation are obtained by the Hirota bilinear method and long wave limit. It is shown that the rational solutions contain dark and bright rogue waves, and their typical dynamics are analysed and illustrated. The semirational solutions possess a range of hybrid solutions, and the hybrid of rogue wave and solitons are demonstrated in detail by the three-dimensional figures. Under certain parameter conditions, a new kind of semirational solutions consisted of rogue waves, breathers and solitons is discovered, which describes the dynamics of the rogue waves interacting with the breathers and solitons at the same time.
Thermal Conductance of a Surface Phonon-Polariton Crystal Made up of Polar Nanorods
Authors: Ordonez-Miranda Jose , Joulain Karl , Ezzahri Younes 
Published: January 2017

Abstract
We demonstrate that the energy transport of surface phonon-polaritons can be large enough to be observable in a crystal made up of a three-dimensional assembly of nanorods of silicon carbide. The ultralow phonon thermal conductivity of this nanostructure along with its high surface area-to-volume ratio allows the predominance of the polariton energy over that generated by phonons. The dispersion relation, propagation length, and thermal conductance of polaritons are numerically determined as functions of the radius and temperature of the nanorods. It is shown that the thermal conductance of a crystal with nanorods at 500 K and diameter (length) of 200 nm (20 μm) is 0.55 nW·K−1, which is comparable to the quantum of thermal conductance of polar nanowires.
Synthesis and Characterization of Zinc Oxide and Evaluation of its Catalytic Activities for Oxidative Degradation of Rhodamine B Dye in Aqueous Medium
Authors: Saeed Muhammad , Siddique Mohsin , Usman Muhammad , ul Haq Atta , Khan Samreen Gul , Raoof Hafiz Abdur 
Published: January 2017

Abstract
We herein report the synthesis of zinc oxide and evaluation of its catalytic performance for degradation of Rhodamine B dye in aqueous medium. Sodium hydroxide and zinc acetate dihydrate were used as precursor materials for synthesis of zinc oxide catalyst. X-ray difractometry, Fourier transform infer red spectroscopy, scanning electron microscopy, thermogravimetric and surface area analyses were used as characterization techniques. Catalytic performance of prepared zinc oxide was evaluated for degradation of Rhodamine B dye in aqueous medium. Catalytic degradation of dye was taking place according to Eley-Rideal mechanism which states that oxygen adsorbed at the surface of ZnO reacts with dye in fluid phase. During the reaction, reactive radicals are formed as a result of electron-hole pair formation between conduction and valence band of zinc oxide catalyst which degrade the dye into water and carbon dioxide.
Implementing Landmine Single-Leg Romanian Deadlift into an Athlete's Training Program
Authors: Weaver Ashley N. , Kerksick Chad M. 
Published: January 2017

ABSTRACT
THE LANDMINE SINGLE-LEG ROMANIAN DEADLIFT (LANDMINE SL RDL) IS CLASSIFIED AS A UNILATERAL LOWER-BODY MOVEMENT THAT CAN BE USED TO BUILD STABILITY, STRENGTH, AND POWER THROUGHOUT AN ATHLETE'S POSTERIOR CHAIN AND CORE. THERE ARE CURRENTLY LITTLE TO NO ARTICLES PUBLISHED THAT DISCUSS THE USE OF LANDMINE EXERCISES. CONSEQUENTLY, THE PURPOSE OF THIS ARTICLE IS THREE-FOLD TO: (A) PROVIDE A DETAILED DISCUSSION ON HOW TO EXECUTE THE LANDMINE SL RDL PROPERLY, (B) DISCUSS THE BENEFITS OF THIS MOVEMENT, AND (C) DISCUSS HOW COACHES AND STRENGTH AND CONDITIONING PROFESSIONALS CAN INTEGRATE IT INTO PRACTICE.
Dynamic Encoding of Acoustic Features in Neural Responses to Continuous Speech
Authors: Khalighinejad Bahar , Cruzatto da Silva Guilherme , Mesgarani Nima 
Published: January 2017

Humans are unique in their ability to communicate using spoken language. However, it remains unclear how the speech signal is transformed and represented in the brain at different stages of the auditory pathway. In this study, we characterized electroencephalography responses to continuous speech by obtaining the time-locked responses to phoneme instances (phoneme-related potential). We showed that responses to different phoneme categories are organized by phonetic features. We found that each instance of a phoneme in continuous speech produces multiple distinguishable neural responses occurring as early as 50 ms and as late as 400 ms after the phoneme onset. Comparing the patterns of phoneme similarity in the neural responses and the acoustic signals confirms a repetitive appearance of acoustic distinctions of phonemes in the neural data. Analysis of the phonetic and speaker information in neural activations revealed that different time intervals jointly encode the acoustic similarity of both phonetic and speaker categories. These findings provide evidence for a dynamic neural transformation of low-level speech features as they propagate along the auditory pathway, and form an empirical framework to study the representational changes in learning, attention, and speech disorders.SIGNIFICANCE STATEMENTWe characterized the properties of evoked neural responses to phoneme instances in continuous speech. We show that each instance of a phoneme in continuous speech produces several observable neural responses at different times occurring as early as 50 ms and as late as 400 ms after the phoneme onset. Each temporal event explicitly encodes the acoustic similarity of phonemes, and linguistic and nonlinguistic information are best represented at different time intervals. Finally, we show a joint encoding of phonetic and speaker information, where the neural representation of speakers is dependent on phoneme category. These findings provide compelling new evidence for dynamic processing of speech sounds in the auditory pathway.
An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+Channels inAplysiaNeurons
Authors: Zhang Yalan , Ni Weiming , Horwich Arthur L. , Kaczmarek Leonard K. 
Published: January 2017

Mutations that alter levels of Slack (KCNT1) Na+-activated K+current produce devastating effects on neuronal development and neuronal function. We now find that Slack currents are rapidly suppressed by oligomers of mutant human Cu/Zn superoxide dismutase 1 (SOD1), which are associated with motor neuron toxicity in an inherited form of amyotrophic lateral sclerosis (ALS). We recorded from bag cell neurons ofAplysia californica, a model system to study neuronal excitability. We found that injection of fluorescent wild-type SOD1 (wt SOD1YFP) or monomeric mutant G85R SOD1YFP had no effect on net ionic currents measured under voltage clamp. In contrast, outward potassium currents were significantly reduced by microinjection of mutant G85R SOD1YFP that had been preincubated at 37°C or of cross-linked dimers of G85R SOD1YFP. Reduction of potassium current was also seen with multimeric G85R SOD1YFP of ∼300 kDa or >300 kDa that had been cross-linked. In current clamp recordings, microinjection of cross-linked 300 kDa increased excitability by depolarizing the resting membrane potential, and decreasing the latency of action potentials triggered by depolarization. The effect of cross-linked 300 kDa on potassium current was reduced by removing Na+from the bath solution, or by knocking down levels of Slack using siRNA. It was also prevented by pharmacological inhibition of ASK1 (apoptosis signal-regulating kinase 1) or of c-Jun N-terminal kinase, but not by an inhibitor of p38 mitogen-activated protein kinase. These results suggest that soluble mutant SOD1 oligomers rapidly trigger a kinase pathway that regulates the activity of Na+-activated K+channels in neurons.SIGNIFICANCE STATEMENTSlack Na+-activated K+channels (KCNT1, KNa1.1) regulate neuronal excitability but are also linked to cytoplasmic signaling pathways that control neuronal protein translation. Mutations that alter the amplitude of these currents have devastating effects on neuronal development and function. We find that injection of oligomers of mutant superoxide dismutase 1 (SOD1) into the cytoplasm of invertebrate neurons rapidly suppresses these Na+-activated K+currents and that this effect is mediated by a MAP kinase cascade, including ASK1 and c-Jun N-terminal kinase. Because amyotrophic lateral sclerosis is a fatal adult-onset neurodegenerative disease produced by mutations in SOD1 that cause the enzyme to form toxic oligomers, our findings suggest that suppression of Slack channels may be an early step in the progression of the disease.
In SilicoScrutiny of Genes Revealing Phylogenetic Congruence with Clinical Prevalence or Tropism Properties ofChlamydia trachomatisStrains
Authors: Ferreira Rita , Antelo Minia , Nunes Alexandra , Borges Vítor , Damião Vera , Borrego Maria José , Gomes João Paulo 
Published: January 2017

AbstractMicrobes possess a multiplicity of virulence factors that confer them the ability to specifically infect distinct biological niches. Contrary to what is known for other bacteria, for the obligate intracellular human pathogen Chlamydia trachomatis, the knowledge of the molecular basis underlying serovars’ tissue specificity is scarce. We examined all ~900 genes to evaluate the association between individual phylogenies and cell-appetence or ecological success of C. trachomatis strains. Only ~1% of the genes presented a tree topology showing the segregation of all three disease groups (ocular, urogenital, and lymphatic) into three well-supported clades. Approximately 28% of the genes, which include the majority of the genes encoding putative type III secretion system effectors and Inc proteins, present a phylogenetic tree where only lymphogranuloma venereum strains form a clade. Similarly, an exclusive phylogenetic segregation of the most prevalent genital serovars was observed for 61 proteins. Curiously, these serovars are phylogenetically cosegregated with the lymphogranuloma venereum serovars for ~20% of the genes. Some clade-specific pseudogenes were identified (novel findings include the conserved hypothetical protein CT037 and the predicted α-hemolysin CT473), suggesting their putative expendability for the infection of particular niches. Approximately 3.5% of the genes revealed a significant overrepresentation of nonsynonymous mutations, and the majority encode proteins that directly interact with the host. Overall, this in silico scrutiny of genes whose phylogeny is congruent with clinical prevalence or tissue specificity of C. trachomatis strains may constitute an important database of putative targets for future functional studies to evaluate their biological role in chlamydial infections.