bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Different Staining Methods in the Diagnosis of Pigment‐Rich Melanoma
Authors: Chengmin Zhou , Jiayu Li , Jun Hou , Yang Liu , Zhou Yehan 
Published: September 2024

ABSTRACTObjectiveTo compare the application of different treatments in the diagnosis of melanoma with severe pigment interference, to solve the problem of pigment interference with immunohistochemical interpretation.MethodsThe pigment‐rich melanomas were first depigmented with potassium permanganate using a concentration gradient (0.1%, 0.5%, 1%) and a time gradient (1, 5, 10, 15, 30 min, 6 h), and the optimal concentration and time were found. Then, 12 cases of pigment‐rich melanoma tissues were collected, and the tissues were stained with diaminobenzidine (DAB), alkaline phosphatase‐fast red (AP red), multiplex immunofluorescence (MIF), and 3‐amino‐9‐ethylcarbazole (AEC), and ferrous sulfate, comparing different methods, positive expression of HMB45, MelanA, S100, SOX10, ki67.ResultsFirst, the concentration of 0.5% potassium permanganate after 15 min treatment of the pigment significantly faded, and the intensity of antibody positivity was better than other concentrations and time. Second, after depigmentation treatment, the antibody positivity rate was 41.7%–66.7% for DAB, 66.7%–91.7% for AP red, 83.3%–100% for multiplex immunofluorescence, 25%–33.3% for AEC, and 33.3% for ferrous sulfate.ConclusionAP red staining and mIF are more suitable for the diagnosis of melanoma with severe pigment interference, and AP red staining is more economical and practical.
Moving beyond vulnerability and focusing on resilience: An intersectional posttraumatic growth model for LGBTQ+ people of color
Authors: Obenauf Caterina , Szymanski Dawn M. , Owens Gina P. 
Published: September 2024

AbstractIn the context of the legacy of deficit‐focused research and application of theoretical models in research on minoritized groups that are underrepresented in the literature, we explored the strengths‐based literature among lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people of color to develop a more inclusive and relevant understanding of how posttraumatic growth (PTG) occurs in this population. Our intersectional PTG model is tailored to the experiences of LGBTQ+ people of color that builds upon previous models of PTG, intersectionality theory, and empirical findings of trauma and PTG among LGBTQ+ people of color. Our intersectional PTG model incorporates the unique intrapersonal, interpersonal, institutional, and cultural factors that are unique to this population and contribute to PTG. We challenge the limited scope of Criterion A traumatic events and emphasize empirical findings that support that LGBTQ+ people of color often experience posttraumatic stress after oppression and discrimination. Our model also recognizes the impact of intersecting risk factors, such as gendered racism, that may occur on various levels. Our model acknowledges that LGBTQ+ people of color have often demonstrated PTG in the face of adversity. Intrapersonal factors such as cognitive flexibility, interpersonal factors such as social support, and institutional and cultural factors such as identity‐related activism are identified as key contributors to resilience. We discuss practice implications, highlighting that clinicians should recognize limitations of traditional trauma frameworks and adopt culturally sensitive approaches when working with LGBTQ+ people of color. Overall, our model provides a foundation for strengths‐based interventions and research, emphasizing resiliency and potential for PTG in this population.
Microplastics induced ileum damage: Morphological and immunohistochemical study
Authors: Saleh Shaimaa M. M. , Abdel‐Zaher Souzan , Mohamed Mahmoud S. , Sayed Alaa El‐Din H. 
Published: September 2024

AbstractMicroplastics (MPs) are small pieces of plastic that are widely distributed in the environment and accumulate within living organisms, so they are the most common types of pollutants at the present time. One of the most widespread types of MP in the environment is polyethylene (PE) MPs. There have been many published studies on the effect of PE MPs combined with other pollutants or chemicals such as benzoanthracene, emamectin benzoate, heavy metals and 4‐nonylphenol, on some marine, amphibian, and mouse models. However, research has rarely been conducted on how single‐use PE MPs affect the ileum of mammals. The current study is focused on the impact of PE MP exposure with different concentration (6, 60, 600 μg/mL PE/MPs) for 15 days, followed by 15 days of recovery on small intestine(ileum) of C57BL/6 murine model with precision and detail at the cell level by using different technique (histology, histochemistry, immunohistochemistry, and transmission electron microscope). Results demonstrated that the intestinal tissue exhibited nuclear pyknosis, villus deformation, shortness of villi, degeneration of lamina propria, hyperplasia of goblet cells, increase of goblet cells secretion, Alcian blue and Periodic acid–Schiff stain positivity of intact goblet cells, highly significance of P53 immunoreaction expression specially in high concentrations (600 μg/day of PE/MPs) and Ki‐67 immunoreaction expression.Research Highlights
Different doses of microplastics (MPs) induced sever morphological alternations and clinical observations.
MPs were deposits in cells and were observed in ultrastructure study.
Recovery period able to ameliorate to the most extent the alternations caused by MPs administration.
Platelet‐rich plasma intra‐articular knee injections from open preparation techniques do not pose a higher risk of joint infection: A systematic review of 91 randomized controlled trials and 5914 injections
Authors: Alazzeh Mohammad Sami , Naseh Hamza Adnan Mohammad , Vasiliadis Angelo , Laupheimer Markus , Kalifis Georgios , Al‐Dolaymi Ayyoub , Macchiarola Luca , Marín Fermín Theodorakys 
Published: September 2024

AbstractPurposeTo compare the infection rate of intraarticular platelet‐rich plasma (PRP) knee injections between open and closed techniques in randomized controlled trials (RCTs) published in the last decade.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, PubMed, Scopus and Virtual Health Library were accessed in October 2022 using the terms ‘platelet‐rich plasma’, ‘PRP’, ‘knee’ and ‘tibiofemoral’ alone and in combination with Boolean operators AND/OR. RCTs published during the last 10 years evaluating PRP intra‐articular knee injections were considered eligible. Studies were excluded if the kit/preparation technique was not described. Data were presented using individual studies' absolute values, totals, and pooled percentages. Publication bias was assessed using the ROBIS tool.ResultsNinety‐one studies met the predetermined eligibility criteria. Forty‐one implemented a closed technique, while 50 were open. All studies implementing a closed technique disclosed their commercial kits. Only 16 studies (17.58%) failed to report joint infections. Among the studies reporting joint infections as outcomes, 30 implemented a closed technique with 1195 patients, 1921 intra‐articular knee injections and 95.44% of patient follow‐up. On the other hand, 45 of them implemented an open technique with 2290 patients, 3993 intra‐articular knee injections and 97.07% of patient follow‐up. No patient had a joint infection among the included studies. Thirty‐three studies prepared their PRP in controlled environments (36.26%). Most studies did not report where the preparation occurred (48.35%). Only twelve studies disclosed using laminar flow during preparation (13.19%). The infection rate for both techniques was 0 per 1000 knee injections.ConclusionOpen PRP preparation techniques do not pose a higher risk of joint infection and can lower manufacturing costs when appropriate facilities are available. However, PRP preparation setting and laminar flow implementation data are deficient, and minimal requirements for good manufacturing practices demand further studies while adhering to local and regional regulations.Level of EvidenceLevel I, systematic review of RCTs.
Short rainbow cycles for families of matchings and triangles
Authors: Guo He 
Published: September 2024

AbstractA generalization of the famous Caccetta–Häggkvist conjecture, suggested by Aharoni, is that any family of sets of edges in , each of size , has a rainbow cycle of length at most . In works by the author with Aharoni and by the author with Aharoni, Berger, Chudnovsky, and Zerbib, it was shown that asymptotically this can be improved to if all sets are matchings of size 2, or all are triangles. We show that the same is true in the mixed case, that is, if each is either a matching of size 2 or a triangle. We also study the case that each is a matching of size 2 or a single edge, or each is a triangle or a single edge, and in each of these cases we determine the threshold proportion between the types, beyond which the rainbow girth goes from linear to logarithmic.
“It's a fight – the whole personality of the patient to win.” The development of concepts of psychosis in the Jewish Hospital in Warsaw, 1898–1943
Authors: Kornaj Jan 
Published: September 2024

AbstractThis study investigates the development of concepts of psychosis in the Jewish Hospital in Warsaw, within the context of social and historical processes to which the hospital was the subject and a broader scope of European concepts of psychosis. In the years 1898–1909, the first chief physician of the psychiatric ward, Adam Wizel, focused mainly on hysteria. The interest in psychoses was initiated by Maurycy Bornsztajn, who started to promote psychoanalytic ideas. The second decade of the functioning of the Jewish Hospital's psychiatric ward was marked by issues concerning the classification of psychoses. In the third decade, after Poland regained independence, psychosis became the main focus of the hospital's staff. Newly appointed psychiatrists, Gustaw Bychowski and Władysław Matecki, contributed substantially to the psychoanalytic understanding of psychosis. Bornsztajn continued to develop his psychoanalytically based concept of psychosis. Wizel changed his attitude toward psychoanalysis and acknowledged the importance of Freud's discoveries. Władysław Sterling contributed to the biological understanding of schizophrenia. In the last period, 1931–1943, the Jewish Hospital in Warsaw struggled with the consequences of the economic crisis in Poland, Wizel's death, and Bychowski's departure, which resulted in the reduced number of publications in the field of psychosis. Nevertheless, Bornsztajn managed to further develop his concept of somatopsychic schizophrenia and Matecki introduced the category of pseudo‐neurotic schizophrenia. The psychoanalytic approach developed by Wizel, Bornsztajn, Bychowski, and Matecki was supplemented with other influences, especially phenomenology. Wizel, Bychowski, and Matecki were advocates of the psychoanalytic psychotherapy of psychotic patients.
PIPAC Pharmacologic and Clinical Data
Authors: Cortés‐Guiral Delia , Kranenburg Onno , Sgarbura Olivia , Van Der Speeten Kurt , Taibi Albdelkader , Hübner Martin , Yacoov Almog Ben 
Published: September 2024

ABSTRACTPressurized intraperitoneal aerosol chemotherapy (PIPAC) emerged as an innovative intraperitoneal chemotherapy delivery system to overcome the issue of limited efficacy of systemic therapies to induce response in peritoneal malignancies. Promising results for patients with mesothelioma peritonei and peritoneal metastasis from gastric, ovarian, colorectal, pancreatic, and hepatobiliary tumors origin are changing the landscape for patients otherwise just facing palliative treatment. Ongoing trials will shed more light on the actual benefits of PIPAC.
Guideline From the Brazilian Society of Surgical Oncology and Brazilian College of Surgeons in Preventing and Managing Acute Hypoparathyroidism After Thyroid Surgery
Authors: Santa Ritta Barreira Carlos Eduardo , Kowalski Luiz Paulo , Dias Fernando Luiz , Farias Terence Pires D. E. , Santos Izabella Costa , Vartanian José Guilherme , Beltrão André Maurício Ferrari , Feitosa Heládio , Neto Ruy Gomes , Oliveira Alexandre Ferreira , Ribeiro Reitan , Vanderlei Felipe Augusto Brasileiro , Duarte Felipe Henning Gaia , Filho Pedro Eder Portari , Pinheiro Rodrigo Nascimento 
Published: September 2024

ABSTRACTThe risk of hypoparathyroidism and hypocalcemia is a critical concern in thyroid surgery. Preserving parathyroid gland vascularization during surgery is essential for effective prevention. Preoperative and postoperative management, including calcium and Vitamin D supplementation, is paramount. Measurement of parathyroid hormone levels after surgery is the best predictor of hypoparathyroidism. This guideline offers recommendations for the prevention, diagnosis, and treatment of acute hypoparathyroidism and hypocalcemia after thyroid surgery.
Novel Quantitative Liver Steatosis Assessment Method With Ultrasound Harmonic Imaging
Authors: Gong Ping , Zhang Jingke , Huang Chengwu , Lok U‐Wai , Tang Shanshan , Liu Hui , DeRuiter Ryan , Petersen Kendra , Knoll Kate , Robinson Kathryn , Watt Kymberly , Callstrom Matthew , Chen Shigao 
Published: September 2024

ObjectivesMetabolic dysfunction‐associated steatotic liver disease (MASLD) is the most prevalent liver disorder in Western countries, with approximately 20%–30% of the MASLD patients progressing to severe stages. There is an urgent need for noninvasive, cost‐effective, widely accessible, and precise biomarkers to evaluate liver steatosis. This study aims to assess and compare the diagnostic performance of a novel reference frequency method‐based ultrasound attenuation coefficient estimation (ACE) in both fundamental (RFM‐ACE‐FI) and harmonic (RFM‐ACE‐HI) imaging for detecting and grading liver steatosis.MethodsAn Institutional Review Board‐approved prospective study was carried out between December 2018 and October 2022. A total number of 130 subjects were enrolled in the study. The correlation between RFM‐ACE‐HI values and magnetic resonance imaging proton density fat fraction (MRI‐PDFF), as well as between RFM‐ACE‐FI values and MRI‐PDFF were calculated. The diagnostic performance of RFM‐ACE‐FI and RFM‐ACE‐HI was evaluated using receiver operating characteristic (ROC) curve analysis, as compared to MRI‐PDFF. The reproducibility of RFM‐ACE‐HI was assessed by interobserver agreement between two sonographers.ResultsA strong correlation was observed between RFM‐ACE‐HI and MRI‐PDFF, with R = 0.88 (95% confidence interval [CI]: 0.83–0.92; P < .001), while the correlation between RFM‐ACE‐FI and MRI‐PDFF was R = 0.65 (95% CI: 0.50–0.76; P < .001). The area under the ROC (AUROC) curve for RFM‐ACE‐HI in staging liver steatosis grades of S ≥ 1 and S ≥ 2 was 0.97 (95% CI: 0.91–0.99; P < .001) and 0.98 (95% CI: 0.93–1.00; P < .001), respectively, and 0.76 (95% CI: 0.65–0.85) and 0.80 (95% CI: 0.70–0.88) for RFM‐ACE‐FI, respectively. Great reproducibility was achieved for RFM‐ACE‐HI, with an interobserver agreement of R = 0.97 (95% CI: 0.94–0.99; P < .001).ConclusionsThe novel RFM‐ACE‐HI method offered high liver steatosis diagnostic accuracy and reproducibility, which has important clinical implications for early disease intervention and treatment evaluation.
Single‐Shot Non‐Invasive Imaging Through Dynamic Scattering Media Beyond the Memory Effect via Virtual Reference‐Based Correlation Holography
Authors: Luo Yuzhen , Wang Zhiyuan , He Hanwen , Vinu R. V. , Luo Songjie , Pu Jixiong , Chen Ziyang 
Published: September 2024

AbstractNon‐invasive wide‐field imaging through dynamic random media is a sought‐after goal with important applications ranging from medical diagnosis to remote sensing. However, some existing methods, such as speckle correlation‐based techniques, are limited in field of view due to the memory effect; while some other methods, such as wavefront shaping and transmission matrix techniques, face considerable challenges when applied in dynamic scenarios because of the complexity involved in modulation and measurement. These limitations significantly impede the effectiveness and applicability of these approaches. Here, the concept of virtual reference light (VRL), which allows for the reconstruction of the original object with just a single‐shot detection of the speckle is proposed. Experimental results demonstrate that the imaging field achieves a 3.8‐fold memory effect range. In the experimental setup, the light source and detector are positioned on one side of the random medium, while the sample is placed on the opposite side, enabling non‐invasive detection. Imaging results with both static and dynamic scattering media are presented to verify the feasibility of the proposed method, offering an effective solution for real‐time target imaging and detection.
Moving from crisis response to a learning health system: Experiences from an Australian regional primary care network
Authors: Forrester Bianca , Fisher Georgia , Ellis Louise A. , Giddy Andrew , Smith Carolynn L. , Zurynski Yvonne , Sanci Lena , Graham Katherine , White Naomi , Braithwaite Jeffrey 
Published: September 2024

AbstractIntroductionThe COVID‐19 pandemic challenged primary care to rapidly innovate. In response, the Western Victorian Primary Health Network (WVPHN) developed a COVID‐19 online Community of Practice comprising general practitioners (GPs), practice nurses, pharmacists, aged care and disability workers, health administrators, public health experts, medical specialists, and consumers. This Experience Report describes our progress toward a durable organizational learning health system (LHS) model through the COVID‐19 pandemic crisis and beyond.MethodsIn March 2020, we commenced weekly Community of Practice sessions, adopting the Project ECHO (Extension of Community Health Outcomes) model for a virtual information‐sharing network that aims to bring clinicians together to develop collective knowledge. Our work was underpinned by the LHS framework proposed by Menear et al. and aligned with Kotter's eight‐step change model.ResultsThere were four key phases in the development of our LHS: build a Community of Practice; facilitate iterative change; develop supportive organizational infrastructure; and establish a sustainable, ongoing LHS. In total, the Community of Practice supported 83 unique COVID‐19 ECHO sessions involving 3192 h of clinician participation and over 10 000 h of organizational commitment. Six larger sessions were run between March 2020 and September 2022 with 3192 attendances. New models of care and care pathways were codeveloped in sessions and network leaders contributed to the development of guidelines and policy advice. These innovations enabled WVPHN to lead the Australian state of Victoria on rates of COVID vaccine uptake and GP antiviral prescribing.ConclusionThe COVID‐19 pandemic created a sense of urgency that helped stimulate a regional primary care‐based Community of Practice and LHS. A robust theoretical framework and established change management theory supported the purposeful implementation of our LHS. Reflection on challenges and successes may provide insights to support the implementation of LHS models in other primary care settings.
Why go gluten‐free? How the feeling of low power increases preferences for free‐from products
Authors: Zhang Lijun (Shirley) , Chan Elaine 
Published: September 2024

AbstractGoing gluten‐free and dairy‐free has become increasingly popular in the past 10 years, yet little research has examined the drivers of this dietary preference beyond medical reasons. This research investigates how the feeling of low power contributes to the growing popularity of free‐from products (e.g., gluten‐free, fragrance‐free). Five studies, using various statistical analyses (including regressions, analysis of variance, mediation, and moderation analysis) across both surveys and experiments, provide converging evidence that the feeling of low power increases preferences for free‐from products, driven by heightened perceived threat. Consistent with this account, low‐power individuals’ increased preference for free‐from products is attenuated (1) when their perceived threat is reduced through self‐affirmation, and (2) when advertising appeals highlight health benefits in a gain (vs. loss) frame. This research contributes to both the special diets and power literatures, offering practical implications for marketers of free‐from products by revealing a potential market segment and suggesting message framing strategies to better persuade consumers.
Substantiating the Short Burst Duration in Cortical Myoclonus
Authors: van der Veen Sterre , Maliepaard Amber , van der Stouwe Madelein , Dalenberg Jelle , Tuitert Inge , Elting Jan Willem J. , Tijssen Marina A.J. 
Published: September 2024

AbstractBackgroundMyoclonus is characterized by involuntary, shock‐like movements, of which cortical (CM) and non‐cortical myoclonus (NCM) are most common. Electrophysiology can help differentiate between these subtypes; however, the diagnostic value of several features is largely unknown.ObjectiveThis study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM.MethodsWe manually identified the burst duration of 8 patients with CM, confirmed by electromyography–electroencephalography registration or somatosensory‐evoked potentials, and 19 patients with NCM, suspected due to a myoclonus‐dystonia phenotype (MYC/DYT‐SGCE positive and negative).ResultsThe sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy.ConclusionThe burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM.
Prediction of Backward Erosion, Pipe Formation and Induced Failure Using a Multi‐Physics SPH Computational Framework
Authors: Ma Guodong , Bui Ha H. , Lian Yanjian , Nguyen Tien V. , Nguyen Giang D. 
Published: September 2024

ABSTRACTSeepage‐induced backward erosion is a complex and significant issue in geotechnical engineering that threatens the stability of infrastructure. Numerical prediction of the full development of backward erosion, pipe formation and induced failure remains challenging. For the first time, this study addresses this issue by modifying a recently developed five‐phase smoothed particle hydrodynamics (SPH) erosion framework. Full development of backward erosion was subsequently analysed in a rigid flume test and a field‐scale backward erosion‐induced levee failure test. The seepage and erosion analysis provided results consistent with experimental data, including pore water pressure evolution, pipe length and water flux at the exit, demonstrating the good performance of the proposed numerical approach. Key factors influencing backward erosion, such as anisotropic flow and critical hydraulic gradient, are also investigated through a parametric study conducted with the rigid flume test. The results provide a better understanding of the mechanism of backward erosion, pipe formation and the induced post‐failure process.