bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Copper‐Mediated Aromatic 1,1‐Difluoroethylation with (1,1‐Difluoroethyl)trimethylsilane (TMSCF2CH3).
Authors: Li Xinjin , Zhao Jingwei , Wang Yunze , Rong Jian , Hu Mingyou , Chen Dingben , Xiao Pan , Ni Chuanfa , Wang Limin , Hu Jinbo 
Published: October 2016

AbstractThe practical title reaction tolerates various functional groups, including complex steroids.
ChemInform Abstract: Eosin Y (EY) Photoredox‐Catalyzed Sulfonylation of Alkenes: Scope and Mechanism.
Authors: Meyer Andreas Uwe , Strakova Karolina , Slanina Tomas , Koenig Burkhard 
Published: October 2016

AbstractAlkyl‐ and aryl vinyl sulfones are obtained by eosin Y (EY)‐mediated visible‐light photooxidation of sulfinate salts and reaction of the resulting S‐centered radicals with alkenes.
ChemInform Abstract: Intramolecular Oxidative Palladium‐Catalyzed Diamination Reactions of Alkenyl Sulfamates: An Efficient Synthesis of [1,2,5]Thiadiazolo‐fused Piperazinones.
Authors: Chiacchio Ugo , Broggini Gianluigi , Romeo Roberto , Gazzola Silvia , Chiacchio Maria A. , Giofre Salvatore V. , Gabriele Bartolo , Mancuso Raffaella , Floresta Giuseppe , Zagni Chiara 
Published: October 2016

AbstractAn intramolecular diamination of N‐allylic glycine‐derived sulfamates leads to thiadiazolo‐fused piperazinones in good yields.
ChemInform Abstract: Visible‐Light‐Induced Photocatalytic Azotrifluoromethylation of Alkenes with Aryldiazonium Salts and Sodium Triflinate.
Authors: Yu Xing‐Long , Chen Jia‐Rong , Chen Dong‐Zhen , Xiao Wen‐Jing 
Published: October 2016

AbstractThe reaction tolerates variously functionalized aryl diazonium salts as well as terminal, 1,1‐ and cyclic or acyclic 1,2‐disubstituted alkenes.
ChemInform Abstract: One‐Pot Synthesis of α‐Amino Acids Through Carboxylation of Ammonium Ylides with CO2 Followed by Alkyl Migration.
Authors: Mita Tsuyoshi , Sugawara Masumi , Sato Yoshihiro 
Published: October 2016

AbstractThe method comprises four efficient consecutive transformations, namely ammonium salt formation, carboxylation, esterification and alkyl migration in a simple one‐pot manner.
ChemInform Abstract: Silver‐Mediated anti‐Markovnikov and Markovnikov‐Selective Hydrotrifluoromethylthiolation of Terminal Alkynes.
Authors: Wu Wei , Dai Wenpeng , Ji Xinfei , Cao Song 
Published: October 2016

AbstractThe direct oxidative hydrotrifluoromethylthiolation of terminal alkynes yields vinyl trifluoromethyl thioethers as anti‐Markovnikov and Markovnikov adducts in moderate to good yields depending on the reaction conditions.
ChemInform Abstract: Dearomatizing Spirocyclization Reactions of Alkynyl Cyanamides.
Authors: Singh Ravi P. , Spears Jada A. , Dalipe Alfonso , Yousufuddin Muhammed , Lovely Carl J. 
Published: October 2016

AbstractPropargylic cyanamide (I) is found to be a competent substrate in the electrophile‐initiated dearomatizing spirocyclization with halogens, sulfur and selenium reagents.
ChemInform Abstract: Friedel—Crafts Alkylation of Arenes with 2‐Halogeno‐2‐CF3‐styrenes under Superacidic Conditions. Access to Trifluoromethylated Ethanes and Ethenes.
Authors: Sandzhieva Maria A. , Kazakova Anna N. , Boyarskaya Irina A. , Ivanov Alexandr Yu. , Nenajdenko Valentine G. , Vasilyev Aleksander V. 
Published: October 2016

AbstractThe hydroarylation reaction proceeds via benzyl cations formed under protonation in a superacid as proved by NMR spectroscopy and theoretical DFT calculations.
ChemInform Abstract: Synthesis of Indole‐Substituted Indanones via Palladium(II)‐Catalyzed Tandem Reaction of ortho‐Electron‐Deficient Alkynyl‐Substituted Aryl Aldehydes with Indoles.
Authors: Zhang Jianbo , Han Xiuling , Lu Xiyan 
Published: October 2016

AbstractThis efficient and economical cyclization reaction of ortho‐alkynyl aromatic aldehydes with indoles provides indolylindanones.
ChemInform Abstract: Discogens Possessing Aryl Side Groups Synthesized by Suzuki Coupling of Triphenylene Triflates and Their Self‐Organization Behavior.
Authors: Zhao Ke‐Qing , Gao Yue , Yu Wen‐Hao , Hu Ping , Wang Bi‐Qin , Heinrich Benoit , Donnio Bertrand 
Published: October 2016

AbstractPd‐catalyzed Suzuki cross‐coupling reactions between arylboronic acids and bromoarenes is applied in the synthesis of liquid‐crystalline materials.
ChemInform Abstract: 1‐Methylimidazolium Trifluoroacetate Efficiently Catalyzed Three Component Synthesis of Diazaspiro[5.5]undecane‐1,5,9‐trione Derivatives under Solvent‐Free Conditions
Authors: Xu Zhaohui , Zhang Houfu , Lin Chunhua , Liu Deyong 
Published: October 2016

Abstractby reaction of various aromatic aldehydes with urea and dioxanedione
ChemInform Abstract: Acid‐Catalyzed Ring‐Opening Cyclization of Spirocyclopropanes for the Construction of a 2‐Arylbenzofuran Skeleton: Total Synthesis of Cuspidan B.
Authors: Nambu Hisanori , Ono Naoki , Yakura Takayuki 
Published: October 2016

AbstractThe utility of this method is demonstrated in the first total synthesis of cuspidan B (V).
ChemInform Abstract: Transition‐Metal‐Free TBAI‐Facilitated Addition—Cyclization of N‐Methyl‐N‐arylacrylamides with Arylaldehydes or Benzenesulfonohydrazides: Access to Carbonyl‐ and Sulfone‐Containing N‐Methyloxindoles.
Authors: Ji Peng‐Yi , Zhang Ming‐Zhong , Xu Jing‐Wen , Liu Yu‐Feng , Guo Can‐Cheng 
Published: October 2016

AbstractIn comparison to previously developed methods, the presented protocol offers a safe and environmentally friendly approach to carbonyl and sulfone‐containing oxindoles in moderate to high yields.
ChemInform Abstract: Aerobic Radical‐Cascade Alkylation/Cyclization of α,β‐Unsaturated Amides: An Efficient Approach to Quaternary Oxindoles.
Authors: Biswas Promita , Paul Subhasis , Guin Joyram 
Published: October 2016

AbstractAn unprecedented method for the aerobic radical alkylarylation of electron‐deficient amides through dual C—H functionalization under metal‐ and peroxide‐free conditions is presented.
ChemInform Abstract: Regioselective Synthesis of Pyrazole and Pyridazine Esters from Chalcones and α‐Diazo‐β‐ketoesters.
Authors: Nair Deepa , Pavashe Prashant , Katiyar Savita , Namboothiri Irishi N.N. 
Published: October 2016

AbstractBase mediated deacylation of title compounds (II) generates diazoester anion, a reactive 1,3‐dipol, which undergoes [3 + 2] annulation with chalcones (I) to afford pyrazole ketoesters (III).
ChemInform Abstract: Synthesis of Oxazolidinones from Epoxides and Isocyanates Catalyzed by Aluminium Heteroscorpionate Complexes.
Authors: Castro‐Osma Jose A. , Earlam Amy , Lara‐Sanchez Agustin , Otero Antonio , North Michael 
Published: October 2016

AbstractThe reaction has a broad substrate scope, thus tolerating functionalized aryl and alkyl substituted epoxides and arylisocyanates, but no alkyl isocyanates.
ChemInform Abstract: Sustainable Synthesis of 2‐Arylbenzoxazoles over a Cobalt‐Based Nanocomposite Catalyst.
Authors: He Jian , Lin Fu , Yang Xufang , Wang Di , Tan Xiaohua , Zhang Shujun 
Published: October 2016

AbstractThe new cobalt‐based heterogeneous catalyst is prepared by adsorbing in situ produced nitrogen‐ligated cobalt(II) acetate complexes on commercially available SiO2 and subsequent pyrolysis at 800 °C for 2 h under N2 atmosphere.
ChemInform Abstract: Design, Synthesis and Characterization of New 1,2,3‐Triazolyl Pyrazole Derivatives as Potential Antimicrobial Agents via a Vilsmeier—Haack Reaction Approach.
Authors: Bhat Manjunatha , Nagaraja G. K. , Kayarmar Reshma , Peethamber S. K. , Shafeeulla R. Mohammed 
Published: October 2016

AbstractSome of the title pyrazole derivatives are found to be potent and broad spectrum antibacterial agents.
ChemInform Abstract: The Study of [4 + 2] Cycloaddition Reactions of Some Unactivated Aldehydes with a Simple Diene: Role of Various Iron(III) Porphyrins as Catalysts.
Authors: Singh Manoj Kumar , Kumar Manoj , Bandyopadhyay Debkumar 
Published: October 2016

AbstractThe [4+2] cycloaddition reaction of aromatic aldehydes with 2,3‐dimethyl‐1,3‐butadiene catalyzed by various iron(III) porphyrins is studied.
ChemInform Abstract: Efficient Access to Alkynylated Quinalizinones via the Gold(I)‐Catalyzed Aminoalkynylation of Alkynes.
Authors: Shinde Popat S. , Shaikh Aslam C. , Patil Nitin T. 
Published: October 2016

AbstractFurther derivatization of the products via Sonogashira‐coupling or azide‐alkyne cycloaddition of the alkyne moiety is demonstrated.
ChemInform Abstract: Nano‐CuCr2O4: An Efficient Catalyst for a One‐Pot Synthesis of Tetrahydrodipyrazolopyridine.
Authors: Shahbazi‐Alavi Hossein , Safaei‐Ghomi Javad , Eshteghal Fahime , Zahedi Safura , Nazemzadeh Seyed Hadi , Alemi‐Tameh Fatemeh , Tavazo Maryam , Basharnavaz Hadi , Lashkari Mohammad Rasool 
Published: October 2016

AbstractThe title compounds are prepared by multicomponent cyclocondensation of ethyl acetoacetate, benzaldehydes, ammonium acetate, and hydrazine hydrate in short times and with good to high yields.
ChemInform Abstract: Samarium‐Mediated Intramolecular Cross‐Couplings of an α,β‐Unsaturated N‐Acylpyrrole.
Authors: Law Katherine R. , McErlean Christopher S. P. 
Published: October 2016

AbstractTitle compound (I) is shown to be a suitable substrate for SmI2‐mediated reductive cyclization to give a trans,syn,trans‐fused tetrahydropyran (II).
ChemInform Abstract: Catalytic Asymmetric [3 + 3] Annulation of Cyclopropanes with Mercaptoacetaldehyde.
Authors: Fu Xuan , Lin Lili , Xia Yong , Zhou Pengfei , Liu Xiaohua , Feng Xiaoming 
Published: October 2016

AbstractThe highly diastereoselective and enantioselective title reaction of aryl substituted cyclopropyl ketones with mercaptoacetaldehyde is described.
ChemInform Abstract: Zn‐Catalyzed Hydrohydrazination of Propargylamides with BocNHNH2: A Novel Entry into the 1,2,4‐Triazine Core.
Authors: Lukin Alexey , Vedekhina Tatiana , Tovpeko Dmitry , Zhurilo Nikolay , Krasavin Mikhail 
Published: October 2016

AbstractThe convenient one‐pot protocol allows the synthesis of triazines via a sequential hydroazination/cyclodehydration/oxidation process.
ChemInform Abstract: Gold(I)‐Catalyzed Azepine Synthesis from Propargyl Acetals and Aryl Azides.
Authors: Evjen Sigvart , Fiksdahl Anne 
Published: October 2016

AbstractThe reaction proceeds by a sequential two‐step pathway via an activated Z‐2‐methoxy vinyl imine intermediate, with a final [4+3] cycloaddition.
ChemInform Abstract: Asymmetric Aza‐Morita—Baylis—Hillman Reactions of Chiral N‐Phosphonyl Imines with Acrylates via GAP Chemistry/Technology.
Authors: Yang Bing , Ji Xiaozhou , Xue Yunsheng , Zhang Haowei , Shen Minxing , Jiang Bo , Li Guigen 
Published: October 2016

AbstractThe atom‐economical reaction proceeds with excellent diastereo and enantioselectivity.
ChemInform Abstract: Asymmetric Syntheses of (+)‐Preussin B, the C(2)‐Epimer of (‐)‐Preussin B, and 3‐Deoxy‐(+)‐preussin B.
Authors: Buchman Marek , Csatayova Kristina , Davies Stephen G. , Fletcher Ai M. , Houlsby Ian T. T. , Roberts Paul M. , Rowe Sam M. , Thomson James E. 
Published: October 2016

AbstractEfficient de novo asymmetric syntheses of the title antifungal alkaloids are described.
ChemInform Abstract: Flexible Total Synthesis of (.+‐.)‐Aureothin, a Potent Antiproliferative Agent.
Authors: Henrot Matthias , Jean Alexandre , Peixoto Philippe A. , Maddaluno Jacques , De Paolis Michael 
Published: October 2016

AbstractThe synthesis of (.+‐.)‐aureothin (I) as well as imino (Ib,c) or keto group (Id) derivatives thereof is presented.
ChemInform Abstract: Iridium‐Catalyzed Diastereo‐, Enantio‐, and Regioselective Allylic Alkylation with Prochiral Enolates
Authors: Hethcox J. Caleb , Shockley Samantha E. , Stoltz Brian M. 
Published: October 2016

AbstractReview: 33 refs.
ChemInform Abstract: Ring‐Opening Reactions of Oxetanes: A Review of Methodology Development and Synthetic Applications
Authors: Ahmad Sajjad , Yousaf Muhammad , Mansha Asim , Rasool Nasir , Zahoor Ameer Fawad , Hafeez Freeha , Rizvi Sayyad Muhammad Ali 
Published: October 2016

AbstractReview: 53 refs.
Impact of chronic disease on emotional distress in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study
Authors: Vuotto Stefanie C. , Krull Kevin R. , Li Chenghong , Oeffinger Kevin C. , Green Daniel M. , Patel Sunita K. , Srivastava Deokumar , Stovall Marilyn , Ness Kirsten K. , Armstrong Gregory T. , Robison Leslie L. , Brinkman Tara M. 
Published: October 2016

BACKGROUNDThe current study was performed to examine associations between childhood cancer therapies, chronic health conditions, and symptoms of emotional distress in adult survivors of childhood cancer.METHODSParticipants included 5021 adult survivors of childhood cancer (mean age, 32.0 years [standard deviation, 7.6 years] with a time since diagnosis of 23.2 years [standard deviation, 4.5 years]) who completed measures assessing symptoms of anxiety, depression, and posttraumatic stress. Cardiac, pulmonary, and endocrine conditions were graded using the National Cancer Institute Common Terminology Criteria for Adverse Events (version 4.03; grades 1‐4). Structural equation modeling was used to examine hypothesized pathways between cancer treatment exposures, chronic health conditions, and symptoms of emotional distress. Multivariable models were used to estimate relative risks (RRs) for associations between chronic health conditions and distress.RESULTSSurvivors with cardiovascular, endocrine, or pulmonary conditions were found to have a significantly higher prevalence of emotional distress symptoms. In path analyses and multivariable models, significant effects were observed between endocrine (β = .12 [P = .002] and RR, 1.3 [95% confidence interval (95% CI), 1.1‐1.6]) and pulmonary (β = .13 [P<.001] and RR, 1.4 [95% CI, 1.1‐1.7]) conditions and depression, and between cardiac (β = .13 [P = .001] and RR, 1.5 [95% CI, 1.2‐1.8]) and pulmonary (β = .15 [P<.001] and RR, 1.6 [95% CI, 1.3‐2.0]) conditions and anxiety. All treatment‐related chronic health conditions were found to be associated with posttraumatic stress symptoms (cardiac: β = .09 [P = .004] and RR, 1.3 [95% CI, 1.2‐1.5]; endocrine: β = .12 [P<.001] and RR, 1.3 [95% CI, 1.2‐1.5]; and pulmonary: β = .13 [P<.001] and RR, 1.4 [95% CI, 1.2‐1.6]).CONCLUSIONSChronic health conditions resulting from childhood cancer therapies contribute to emotional distress in adult survivors. Targeted mental health screening efforts in this at‐risk population appear warranted. Therapeutic approaches should consider the complex interplay between chronic health conditions and symptoms of emotional distress. Cancer 2017;123:521–528. © 2016 American Cancer Society.
Enzymatic Bioelectrosynthetic Ammonia Production: Recent Electrochemistry of Nitrogenase, Nitrate Reductase, and Nitrite Reductase
Authors: Milton Ross D. , Minteer Shelley D. 
Published: October 2016

AbstractAs an essential component of amino acids and nucleic acids, nitrogen (N) is a key element of life. For atmospheric (dinitrogen, N2) and environmental (nitrate and nitrite, NO3− and NO2−) sources of N to be utilized in amino acid synthesis in various forms of life, it must first be reduced to ammonia (NH3). The Haber–Bosch process, in which N2 is reduced to NH3 at elevated temperature and pressure, represents a major NH3 production process that has had a great impact on the agricultural crop industry. This Minireview discusses the recent electrochemistry of three key enzymes of the global biogeochemical N cycle (nitrogenase, nitrate reductase, and nitrite reductase), in view of moving toward the creation of alternative NH3 production biotechnologies.
Feasibility and Acceptability of the ‘HABIT’ Group Programme for Comorbid Bipolar and Alcohol and Substance use Disorders
Authors: Biseul Isabelle , Icick Romain , Seguin Perrine , Bellivier Frank , Scott Jan 
Published: October 2016

ObjectivesWe investigated the feasibility and acceptability of an integrated group therapy (called HABIT) for comorbid bipolar disorder (BD) and alcohol and substance use disorders (ASUD) (BD‐ASUD), a disabling clinical presentation for which no specific treatment has been validated. The 14‐session HABIT programme employs psychoeducation‐oriented cognitive‐behaviour therapy (CBT) followed by mindfulness‐based relapse prevention (MBRP) therapy.MethodPotential group participants were recruited from adult clients with a DSM‐IV diagnosis of BD and an ASUD who were referred by their treating clinician. Observer‐rated changes in mood symptoms and ASUD, attendance rates and subjective feedback are reported.ResultsEight of 12 clients referred to the programme initially agreed to join the group, six attended the first group session and five clients completed the programme. Group mean scores for mood symptoms improved over time, with slightly greater reductions in depression during the first module. About 50% of individuals showed clinically significant improvement (≥30% reduction) in alcohol and substance use. Attendance rates showed some variability between individuals and across sessions, but the average attendance rate of the group was marginally higher for the first module (86%) as compared with the second module (77%). Most clients reported high levels of general satisfaction with a group specifically targeted at individuals with BD‐ASUD.ConclusionThis small pilot study suggests our intensive group therapy is acceptable and feasible. If findings are replicated, we may have identified a therapy that, for the first time, leads to improvement in both mood and substance use outcomes in clients with difficult‐to‐treat comorbid BD‐ASUD. Copyright © 2016 John Wiley & Sons, Ltd.Key Practitioner Message

Comorbidity between bipolar and alcohol and substance use disorders (BD‐ASUD) is frequent and highly disabling;
Therapeutic research on approaches that can simultaneously help BD and ASUD is lacking;
Previous research highlights the need for integrated treatment of both conditions but showed improvements limited to either element of the comorbid disorder;
This pilot study supports the feasibility and acceptability of an intensive, 14‐session group therapy programme that integrates CBT and mindfulness approaches.
Don't Forget Product Recovery in Catalysis Research—Check the Distillation Resistance
Authors: Lange Jean‐Paul 
Published: October 2016

AbstractWhen investigating a new catalytic reaction, scientists may wonder if the crude reaction product can be easily separated and purified. We present here a new concept—distillation resistance—to assess the potential of distillation as a purification technique and to guide catalyst formulation or operation at the very early stage of the research. Distillation resistance, which has been developed from the analysis of 15 industrial distillation trains, can be quickly calculated with knowledge of only the product composition and atmospheric boiling points of the components. It can be directly converted into a preliminary distillation cost that considers investment and energy cost. Its application and its potential guidance in catalysis research are illustrated through a few cases studies derived from biorefinery processes.
Cool habitats support darker and bigger butterflies in Australian tropical forests
Authors: Xing Shuang , Bonebrake Timothy C. , Tang Chin Cheung , Pickett Evan J. , Cheng Wenda , Greenspan Sasha E. , Williams Stephen E. , Scheffers Brett R. 
Published: October 2016

AbstractMorphology mediates the relationship between an organism's body temperature and its environment. Dark organisms, for example, tend to absorb heat more quickly than lighter individuals, which could influence their responses to temperature. Therefore, temperature‐related traits such as morphology may affect patterns of species abundance, richness, and community assembly across a broad range of spatial scales. In this study, we examined variation in color lightness and body size within butterfly communities across hot and cool habitats in the tropical woodland–rainforest ecosystems of northeast Queensland, Australia. Using thermal imaging, we documented the absorption of solar radiation relative to color lightness and wingspan and then built a phylogenetic tree based on available sequences to analyze the effects of habitat on these traits within a phylogenetic framework. In general, darker and larger individuals were more prevalent in cool, closed‐canopy rainforests than in immediately adjacent and hotter open woodlands. In addition, darker and larger butterflies preferred to be active in the shade and during crepuscular hours, while lighter and smaller butterflies were more active in the sun and midday hours—a pattern that held after correcting for phylogeny. Our ex situ experiment supported field observations that dark and large butterflies heated up faster than light and small butterflies under standardized environmental conditions. Our results show a thermal consequence of butterfly morphology across habitats and how environmental factors at a microhabitat scale may affect the distribution of species based on these traits. Furthermore, this study highlights how butterfly species might differentially respond to warming based on ecophysiological traits and how thermal refuges might emerge at microclimatic and habitat scales.
Classification of California streams using combined deductive and inductive approaches: Setting the foundation for analysis of hydrologic alteration
Authors: Pyne Matthew I. , Carlisle Daren M. , Konrad Cristopher P. , Stein Eric D. 
Published: October 2016

AbstractRegional classification of streams is an early step in the Ecological Limits of Hydrologic Alteration framework. Many stream classifications are based on an inductive approach using hydrologic data from minimally disturbed basins, but this approach may underrepresent streams from heavily disturbed basins or sparsely gaged arid regions. An alternative is a deductive approach, using watershed climate, land use, and geomorphology to classify streams, but this approach may miss important hydrological characteristics of streams. We classified all stream reaches in California using both approaches. First, we used Bayesian and hierarchical clustering to classify reaches according to watershed characteristics. Streams were clustered into seven classes according to elevation, sedimentary rock, and winter precipitation. Permutation‐based analysis of variance and random forest analyses were used to determine which hydrologic variables best separate streams into their respective classes. Stream typology (i.e., the class that a stream reach is assigned to) is shaped mainly by patterns of high and mean flow behavior within the stream's landscape context. Additionally, random forest was used to determine which hydrologic variables best separate minimally disturbed reference streams from non‐reference streams in each of the seven classes. In contrast to stream typology, deviation from reference conditions is more difficult to detect and is largely defined by changes in low‐flow variables, average daily flow, and duration of flow. Our combined deductive/inductive approach allows us to estimate flow under minimally disturbed conditions based on the deductive analysis and compare to measured flow based on the inductive analysis in order to estimate hydrologic change.