bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ontology construction of traditional Chinese medicine diagnosis and treatment for myopia
Authors: Huo Ruili , Zhang Lei , Liu Sihong , Zhang Yu , Jia Siqi , Liu Bing , Chang Anne , Cui Yidi , Tong Lin 
Published: October 2024

Objective:
To keep up with the progress of treatment for myopia in traditional Chinese medicine (TCM) through literature research, so as to determine data source of TCM diagnosis and treatment for myopia, from which entities are extracted for integration of relevant knowledge, and further formal expression and visualization of knowledge.

Methods:
Literature research and comparative analysis were used to determine the data source, and the 7-step method of constructing ontology was referred to for extraction of TCM diagnosis and treatment entities, which then was terminalized for development of classes and class hierarchy, and class properties, as well as creation of instances before consistency test of the ontology.

Results:
The ontology of TCM diagnosis and treatment for myopia includes 26 classes and 124 instances, 9 object properties, and 1 data property.

Conclusion:
The combination of ontology technology and TCM diagnosis and treatment knowledge of myopia contributes to the construction of a knowledge base of TCM diagnosis and treatment ontology for myopia, which realizes formal expression and visualization of relevant TCM knowledge, lays a foundation for the construction of TCM top-level ontology and ophthalmology ontology, and facilitates knowledge reusing and sharing.
The concept of nociplastic pain—where to from here?
Authors: Kosek Eva 
Published: October 2024

Abstract
Nociplastic pain, a third mechanistic pain descriptor in addition to nociceptive and neuropathic pain, was adopted in 2017 by the International Association for the Study of Pain (IASP). It is defined as “pain that arises from altered nociception” not fully explained by nociceptive or neuropathic pain mechanisms. Peripheral and/or central sensitization, manifesting as allodynia and hyperalgesia, is typically present, although not specific for nociplastic pain. Criteria for possible nociplastic pain manifesting in the musculoskeletal system define a minimum of 4 conditions: (1) pain duration of more than 3 months; (2) regional, multifocal or widespread rather than discrete distribution of pain; (3) pain cannot entirely be explained by nociceptive or neuropathic mechanisms; and (4) clinical signs of pain hypersensitivity present in the region of pain. Educational endeavors and field testing of criteria are needed. Pharmacological treatment guidelines, based on the three pain types, need to be developed. Currently pharmacological treatments of nociplastic pain resemble those of neuropathic; however, opioids should be avoided. A major challenge is to unravel pathophysiological mechanisms driving altered nociception in patients suffering from nociplastic pain. Examples from fibromyalgia would include pathophysiology of the peripheral as well as central nervous system, such as autoreactive antibodies acting at the level of the dorsal root ganglia and aberrant cerebral pain processing, including altered brain network architecture. Understanding pathophysiological mechanisms and their interactions is a prerequisite for the development of diagnostic tests allowing for individualized treatments and development of new strategies for prevention and treatment.
Chronic pain in European adult populations: a systematic review of prevalence and associated clinical features
Authors: Rometsch Caroline , Martin Alexandra , Junne Florian , Cosci Fiammetta 
Published: October 2024

Abstract
Chronic pain (CP) is a multifaceted and severely disabling persistent condition that affects individuals worldwide. A synthesis of epidemiological data is still lacking. The present systematic review aims at presenting point, period, and lifetime prevalence estimates of CP in the European adult population, as well as relevant features associated with it. Following PRISMA guidelines, a systematic search in PubMed, Web of Science, Embase, and Cochrane library was run from inception to May 2024, resulting in 39,832 hits. Among those, 132 full-text articles were assessed, and 23 studies comprising 862,013 participants with CP were included. The Joanna Biggs Institutes' Critical Appraisal Checklist for Studies Reporting Prevalence Data (JBI) was used for quality assessment. Findings showed a point prevalence ranging from 12% to 48%, a 6-month prevalence of 17.5% to 49.8%, a 12-month prevalence ranging from 8.1% to 44.6%, and a lifetime prevalence ranging from 12.7% to 33.7% independently from sex. Sociodemographic factors (eg, female sex, higher age, no partnership, lower education, unemployment) and clinical features (eg, medical diseases, mental disorders and burdens, healthcare utilization, functional impairment) were identified as being associated with CP. The variability in prevalence estimates can be reduced by applying consistent diagnostic criteria (eg, ICD-11) and by using standardized assessment tools (eg, scales, clinical interview). The high prevalence and the characteristics of the associated features support the need for adequate, multicomponent care paths to manage CP based on a comprehensive biopsychosocial model.
Prior Concussion History and Clinical Recovery Following Sport-Related Concussion in College Athletes
Authors: Gaudet Charles E. , Iverson Grant L. , Zafonte Ross , Berkner Paul D. , Cook Nathan E. 
Published: October 2024

Objective:
The aim of this study was to assess whether a history of prior concussions, and especially multiple prior concussions, is associated with clinical recovery following a subsequent sport-related concussion among collegiate student athletes.

Design:
A naturalistic observational cohort study.

Setting:
Eleven National Collegiate Athletics Association Division III colleges.

Participants:
Collegiate athletes sustaining concussions from September 2014 through March 2020.

Independent Variables:
Participants were divided into 3 groups, athletes with: (1) no prior concussion history, (2) one prior concussion, and (3) 2 or more prior concussions.

Main Outcome Measures:
Survival analyses were used to compare time to return to school and sports among athletes with a history of 0, 1, or ≥2 prior concussions.

Results:
Among the 1132 college athletes, there were no statistically significant group differences between those with 0, 1, or ≥2 prior concussions in total time to return to school or sports. There was a statistically significant difference in the proportion of athletes with ≥2 prior concussions that had not fully returned to school, without accommodations, at 28 days (6.0%) compared to athletes with no prior concussions (2.2%; odds ratio = 2.80, 95% confidence interval 1.29-6.04).

Conclusions:
In summary, concussion history was not associated with time to return to sports following a subsequent sport-related concussion in these college athletes. On average, athletes with prior concussions did not take longer to return to school, although a slightly greater proportion of college athletes with ≥2 prior concussions had not fully returned to school, without accommodations, by 28 days following injury.
TCM-Centric Innovations in WHO's International Standard Terminologies: A Qualitative Exploration
Authors: Lai Han , Moore Aaron Lee , Yan Xiaodan , Li Wei-hong 
Published: October 2024

Abstract:
Traditional Chinese medicine (TCM) is increasingly recognized worldwide as a valuable complementary and alternative medicine. To facilitate global research and collaboration in this field, the World Health Organization (WHO) introduced the International Standard Terminologies on Traditional Chinese Medicine on March 3, 2022. This international terminology translation standard, IST 2022, goes beyond conventional translation by embracing three innovative features: 1) It reflects TCM's foundational philosophy of unity and opposition, emphasizing the interconnectedness among TCM terms during translation. This approach transcends individual term translations to explore the interrelationships among them. 2) It meticulously preserves the integrity of TCM theory. It achieves this by retaining transliterations for unique TCM terms that possess distinct features, thus upholding the essence of TCM. 3) It employs innovative Xiang (Image) cognition, a concept rooted in traditional Chinese thought by helping readers grasp visual and mental imagery associated with each term. This study presents a qualitative analysis based on interviews with 11 TCM translation experts, examining their perspectives on these features and their translational preferences across IST 2007 and 2022 versions. The findings contribute to the standardization and global harmonization of TCM terminology, advocating for clarity, precision, and the advancement of TCM in the international healthcare arena.
Application and clinical effects in lung bullae resection of CT 3-dimensional reconstruction
Authors: Song Shaohui , Yang Jianqiu , Liu Keyuan , Ye Xiangqing 
Published: October 2024

Background:
To investigate the value and clinical effect of computed tomography (CT) 3-dimensional reconstruction technology in lung bullae resection.

Methods:
Ninety-eight patients who underwent thoracoscopic surgical resection of lung bullae in our hospital from February 2019 to February 2023 were selected and divided into 2 groups according to the principle of voluntary participation in the clinical trial, of which 43 cases underwent preoperative spiral CT for thin-layer enhancement or planar CT scanning of lung bullae (control group), and 43 cases were imaged with MimicsMedical 21 software for 3-dimensional reconstruction to develop a surgical plan (observation group). To compare the surgery-related indexes, postoperative complications, pain, and analgesic use between the 2 groups, we measured serum creatine phosphokinase and myoglobin levels.

Results:
The amount of surgical bleeding, drainage volume, hospital stay, and postoperative visual analog scale score of the research group were lower than those of the control group (P < .05), and the duration of analgesic medication was shorter than that of the control group (P < .05), and the levels of serum creatine phosphokinase and myoglobin were lower than those of the control group at 1 and 3 days postoperatively, and the differences were statistically significant (P < .05).

Conclusion:
Preoperative CT 3-dimensional reconstruction technique can clearly show the anatomical structures around the lung bullae and has its application value for precise lung bullae.
Carbon dioxide narcosis following cesarean section in a patient with severe pulmonary hypertension: A case report
Authors: Lyu Song , Liao Min 
Published: October 2024

Rationale:
Managing anesthesia in patients with severe pulmonary conditions involves complex considerations, especially when dealing with high baseline CO2 levels. We present a case that demonstrates the challenges and complexities of anesthesia and postoperative analgesia in a patient with severe pulmonary hypertension and a history of lung disease exacerbated by the interactions of protein-bound drugs.

Patient Concerns:
A 37-year-old woman at 38 weeks of gestation presented with recurrent chest tightness, shortness of breath, and worsening symptoms over a week, which required emergency medical attention.

Diagnosis:
The patient was diagnosed with severe pulmonary hypertension, and echocardiography revealed a pulmonary artery pressure of 106 mm Hg upon admission. Postoperative complications included sudden unconsciousness after low dose (2 µg) sufentanil administration, indicative of carbon dioxide narcosis that could compound pharmacological interactions and her underlying condition.

Interventions:
The patient underwent a cesarean section under spinal anesthesia, which was complicated postoperatively by respiratory depression, requiring naloxone administration and intensive care.

Outcomes:
Despite initial postoperative challenges, the patient’s condition stabilized, allowing eventual discharge.

Lessons:
The clinical course highlighted the need for careful monitoring and prompt intervention in anesthesia in patients with severe pulmonary hypertension, particularly when administering multiple protein-bound drugs. Drug interactions can exacerbate the underlying condition, necessitating diligent oversight to prevent severe complications such as carbon dioxide narcosis.
Network toxicology and molecular docking to investigative the non-acetylcholinesterase mechanisms and targets of cardiotoxicity injury induced by organophosphorus pesticides
Authors: Guo Yongmei , Li Nan 
Published: October 2024

Background:
Organophosphorus pesticides (OPPs) are widely used in the world, however, OPP poisoning often occurs because of improper use and lack of protective measures. Cardiotoxicity injury induced by OPPs is insidious, and it does not receive attention until the end stage of OPP poisoning. Heart failure or arrhythmia gradually becomes the main lethal cause of OPP poisoning patients.

Methods:
In this study, network toxicology and molecular docking were employed to investigate the non-acetylcholinesterase targets and mechanisms of cardiotoxicity injury induced by OPPs.

Results:
One hundred twenty-three targets of dichlorvos, 205 targets of methidathion, and 337 targets of malathion were searched from SwissTargetPreict, STITCH and PharmMapper database. Additionally, 1379 targets related to cardiotoxicity injury were acquired from GeneCards and OMIM database. Ninety-six mutual targets between OPPs and cardiotoxicity injury were considered as the potential cardiotoxicity injury targets induced by OPPs. The protein–protein interaction (PPI) network was constructed using STING database, and 21 core targets were identified by Cytoscape software, such as AKT1, ESR1, HSP90AA1, MAPK1, MMP9, and MAPK8. Gene ontology and KEGG enrichment analysis revealed that cell migration, apoptotic process, protein phosphorylation and signal transduction were the major biological functions associated with OPPs-induced cardiotoxicity injury, and OPPs-induced cardiotoxicity injury might be regulated by MAPK, PI3K-Akt, VEGF signaling pathway. Docking results manifested that the best binding target for dichlorvos, methidathion and malathion were MAPK9 (−7.1 kcal/mol), MAPK1 (−8.1 kcal/mol) and HSP90AA1 (−8.6 kcal/mol) with the lowest affinity, respectively.

Conclusion:
The core targets and non-AchE mechanisms were explored by network toxicology and molecular docking, providing a theoretical basis for the treatment of OPP-induced cardiotoxicity injury.
Skin metastasis of BRCA mutated prostate cancer: A case report and a brief review of literature
Authors: Jubran Salim , Basso Umberto , Milani Anna , Erbetta Elisa , Di Marco Andrea , Pittarello Chiara , Cavasin Nicolò , Lai Eleonora , Stragliotto Silvia , Pierantoni Francesco , Zampiva Ilaria , Bimbatti Davide , Maruzzo Marco 
Published: October 2024

Rationale:
Metastatic castration-resistant prostate cancer has a poor prognosis especially when harboring DNA damage repair gene mutations, nevertheless, in the case of pathogenic BRCA gene mutations, PARPi demonstrated a survival benefit and is a validated treatment. Nowadays, there is no data regarding unusual metastases after these drugs. Cutaneous metastases appear rarely in prostate cancer and were associated with a worse prognosis. Moreover, there are no consolidated data concerning skin tropism of prostate cancer cells, neither in the case of BRCA-associated cancers.

Patient concerns:
Here, we report the case of a patient with a long history of BRCA1-mutated metastatic castration-resistant prostate cancer who developed a skin lesion on the scalp while on his fifth line of systemic therapy with olaparib. After a complete radical surgical excision, the pathology report showed prostate cancer localization.

Diagnoses:
A diagnosis of skin metastasis from prostate cancer was reported.

Outcomes:
The patient then continued olaparib therapy; after 7 months from excision, he experienced further bone and biochemical progression but not cutaneous progression.

Lessons:
A literature review of all reported cases of cutaneous metastasis in prostate cancer was conducted to shed light on the incidence, clinical presentation, diagnosis, treatment, and prognosis of this entity. We also reviewed published cases of skin metastasis in BRCA-associated cancers with an effort to correlate skin involvement with PARPi treatment, BRCAness status, and prognosis.
Study on serum vitamin A level in patients with type 1 diabetes: A systematic review and meta-analysis
Authors: Yuanyuan Guan , Wang Dongjun , Hao Yang , Guan Yun , Bu Huaien , Wang Hongwu 
Published: October 2024

Background:
There is controversy about the relationship between type 1 diabetes and vitamin A (VA) levels in the body. Through meta-analysis, the results of related studies can be aggregated to more accurately estimate the relationship between type 1 diabetes mellitus (T1DM) patients and the level of VA in the body.

Methods:
Our purpose is to review the study to investigate VA levels in type T1DM patients and to provide recommendations for future studies. Until January 2024, we searched the National Library of Medicine (PubMed), Cochrane Library, Embase Databases, Web of Sciences, Scopus, China National Knowledge Infrastructure (CNKI), VIP databases (VIP) and WAN FANG databases. After a systematic search, 8 case-control studies were included in our meta-analysis. In the process of data inclusion and extraction, the 2 reviewers selected literature independently of each other. In this study, RevMan5.3 software was used for meta-analysis.

Results:
Eight case-control studies involving 689 participants were screened. The results after meta-analysis showed that there was a significant difference in serum VA between the patients with T1DM and the control group (standardized mean difference [SMD] = −0.82, 95% CI [−1.29, −0.36], P < .001, random effects model) with significant heterogeneity among these studies (P < .001, I
2 = 84%). Similarly, the difference in the high-performance liquid chromatography (HPLC) subgroup on serum VA (SMD = −0.99, 95% CI [−1.60, −0.38], P = .002) as well as the difference in the countries of Asia and Europe subgroup on serum VA (SMD = −0.60, 95% CI [−1.15, −0.05], P = .03; SMD = −1.06, 95% CI [−1.88, −0.24], P = .01) were suggested to be statistically significant. A significant result was also observed in the National Diabetes Data Group (NDDG) criteria subgroup (SMD = −0.48, 95% CI [−0.85, −0.12]).

Conclusion:
Serum VA levels seem to have decreased in T1DM patients. Further research is needed to strengthen this finding and clarify possible impact mechanisms.
What factors influencing surgical nurses’ competence in implementing person-centered care in the perioperative period?: A cross-sectional study
Authors: Shen Lu , Xu Dongju , Zhang Xiumei 
Published: October 2024

Strengthening the capability of clinical surgical nurses to provide person-centered care (PCC) requires a thorough analysis of several related factors. This study used a descriptive cross-sectional design to investigate the factors that influence surgical nurses’ perioperative competency in the performance of PCC in Anhui, China. A convenience sampling was implemented to administer a questionnaire survey to 437 nurses with more than 1 year of experience working in surgical wards. A web-based cross-sectional questionnaire evaluated the participant’s general sociological information, empathy, job burnout, and nursing competence. The questionnaire were designed and published through the online platform Questionnaire Stars, and the link was distributed through the Internet and WeChat media by the nursing department of their hospital. Data were collected from June to September 2023 and processed by descriptive, correlation, and stepwise multiple regression analyses. Participants with high levels of empathy (β
= 0.502, P < .001), low levels of job burnout (β
= −0.288, P < .001), humanistic nursing training (β
= 0.167, P < .001), and personnel agency (β
= 0.083, P < .001) showed better PCC competence. The regression model analysis showed that 4 influencing factors explained 59.2% of the variance (F = 158.930, P < .001, adjusted R
2 = 0.592). These findings suggest that steps should be taken to strengthen the key factors, such as improving empathy, minimizing job burnout, offering more humanities training, and enhancing personalities, to reinforce PCC competency.
Incidence of respiratory depression between ciprofol and propofol after anesthesia: A systematic review and meta-analysis
Authors: Zeng Jinfang , Cao Qian , Hong Aonan , Gu Zhen , Jian Jinjin , Liang Xiao 
Published: October 2024

Background:
Respiratory depression is a common complication during operative procedures, meanwhile, ciprofol can provide effective sedation for surgical operations. However, there is not enough evidence to prove the advantage of ciprofol in reducing respiratory depression. So, this meta-analysis aimed to assess the efficacy of ciprofol on the incidence of respiratory depression compared with propofol.

Methods:
Two individual researchers conducted searches for randomized controlled trials in PubMed, Embase, and Cochrane Central Register of Controlled Trials. The meta-analysis was performed using Review Manager software.

Results:
Seven trials with a total of 1408 patients were included in this meta-analysis. The results showed that ciprofol could reduce the incidence of respiratory depression compared with propofol (risk difference [RD] = −0.09, 95% confidence interval [CI]: −0.15 to −0.04). Ciprofol significantly reduced the incidence of respiratory depression when the method of administration was intravenous injection (RD = −0.06, 95% CI: −0.10 to −0.03), or continuous infusion (RD = −0.30, 95% CI: −0.45 to −0.15). Meanwhile, ciprofol significantly reduced the incidence of respiratory depression with the dosage not only greater than or equal to 0.4 mg/kg (RD = −0.11, 95% CI: −0.20 to −0.02), but also <0.4 mg/kg (RD = −0.08, 95% CI: −0.13 to −0.02). And ciprofol significantly reduced the incidence of hypoxemia (risk ratio [RR] = 0.47, 95% CI: 0.28 to 0.80), injection pain (RD = −0.32, 95% CI: −0.46 to −0.17), body movement (RR = 0.60, 95% CI: 0.43 to 0.84), dizziness (RR = 0.75, 95% CI: 0.62 to 0.90). Finally, ciprofol did not increase awakening time (standard mean difference [SMD] = 0.15, 95% CI: −0.02 to 0.31).

Conclusion:
From this meta-analysis, it is demonstrated that ciprofol might reduce the incidence of respiratory depression and injection pain. These benefits are important in surgery to ensure safe and rapid postoperative recovery. So, ciprofol may be a safe and appropriate drug with fewer adverse effects used in clinical anesthesia.