bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term exposure to environmental concentration of dinotefuran disrupts ecdysis and sex ratio by dysregulating related gene expressions in Chironomus kiinensis
Authors: Wei Fenghua , Wu Shuangxin , Li Long 
Published: September 2024

IntroductionCurrently, although there have been a few reports on the endocrine-disrupting effects of neonicotinoids, the effect on Chironomidae during long-term exposure remains unknown.MethodsEcdysis and sex ratio, along with ecdysone-relevant gene expressions of representative neonicotinoid dinotefuran on Chironomus kiinensis were investigated at different environmental concentrations by long-term exposure.ResultsA low dose of dinotefuran delayed pupation and emergence via inhibiting ecdysis. Sex ratios of adults shifted toward male-dominated populations with the concentration of dinotefuran increasing. The corresponding transcriptions of ecdysis genes ecr, usp, E74, and hsp70 were significantly downregulated in the midge. For estrogen effects, the vtg gene expression was upregulated, but there was no significant change for the err gene.DiscussionThese results would improve our understanding of the endocrine-disrupting mechanisms of neonicotinoid insecticides to Chironomidae and provide data support for assessing their potential environmental risks.
Distinct bacterial signature in the raw coal with different heating value
Authors: Zou Haijiang , Tian Miaomiao , Xu Jianmin , Li Guowei , Chen Hui , Yang Junjun , Ling Pengtao , Shen Zhenxing , Guo Siyu 
Published: September 2024

IntroductionCoal represents a significant natural resource in our world, and its quality and commercial value is primarily determined by its heating capacity. Numerous scientists worldwide have attempted to explore the impact of various environmental factors on coal rank, yet their conclusions are often inconsistent.MethodsIn this study, the Illumina MiSeq sequencing approach was used to analyze the bacterial community from a low-rank coal mine as well as a high-rank mine. Moreover, we investigated the relationship between the physical and chemical properties of the coal and the bacterial composition.ResultsOverall, we found that the high-rank coal exhibited higher heating value but higher total sulfur and lead levels. Considering the community of bacteria, the abundances of Phascolarctobacterium and Anaerostipes were highly elevated in the high-rank coal group. Most interestingly, the Anaerostipes abundance was correlated with coal quality positively. Additionally, the co-occurrence network of the bacterial community in the high-rank coal group showed much higher complexity. The bacterial functional potential predictions indicated elevated levels of phosphoenolpyruvate carboxykinase ATP, succinate dehydrogenase fumarate reductase flavoprotein subunit, and methylenetetrahydrofolate dehydrogenase NADP methenyltetrahydrofolate cyclohydrolase pathways.ConclusionThis study revealed that high-rank coal had more complicated co-occurrence network and elevated Anaerostipes abundance, which may suggest a potential biological pathway that can be explored to enhance coal quality.
LncSTPred: a predictive model of lncRNA subcellular localization and decipherment of the biological determinants influencing localization
Authors: Hu Si-Le , Chen Ying-Li , Zhang Lu-Qiang , Bai Hui , Yang Jia-Hong , Li Qian-Zhong 
Published: September 2024

IntroductionLong non-coding RNAs (lncRNAs) play crucial roles in genetic markers, genome rearrangement, chromatin modifications, and other biological processes. Increasing evidence suggests that lncRNA functions are closely related to their subcellular localization. However, the distribution of lncRNAs in different subcellular localizations is imbalanced. The number of lncRNAs located in the nucleus is more than ten times that in the exosome.MethodsIn this study, we propose a new oversampling method to construct a predictive dataset and develop a predictive model called LncSTPred. This model improves the Adaboost algorithm for subcellular localization prediction using 3-mer, 3-RF sequence, and minimum free energy structure features.Results and DiscussionBy using our improved Adaboost algorithm, better prediction accuracy for lncRNA subcellular localization was obtained. In addition, we evaluated feature importance by using the F-score and analyzed the influence of highly relevant features on lncRNAs. Our study shows that the ANA features may be a key factor for predicting lncRNA subcellular localization, which correlates with the composition of stems and loops in the secondary structure of lncRNAs.
Parkinson’s disease motor intervention patterns: a network meta-analysis based on patient motor function
Authors: Zhao Hongfei , Zhang Li , Yang Jingling , Guo Wanru , Sun Chunyang , Shi Runbo , Wang Zhen 
Published: September 2024

BackgroundParkinson’s disease is characterized by symptoms such as bradykinesia and rigidity, which worsen as the disease progresses, significantly impacting patients’ independence and quality of life. This study utilizes a network meta-analysis approach to quantify information gathered from randomized controlled trials (RCTs) regarding motor interventions that effectively improve the motor function of Parkinson’s disease patients, aiming to provide evidence for selecting appropriate exercise intervention strategies for patients.MethodsA systematic search strategy for randomized controlled trials (RCTs) restricted to English was constructed based on multiple biomedical databases. Databases searched included PubMed, Embase, Cochrane, Web of Science, CINAHL, CBM, China National Knowledge Infrastructure (CNKI), Wan fang, VIP, etc., with searches conducted from inception to July 9, 2023. Two authors screened all studies, extracted data, and used frequency domain analysis methods. Network meta-analysis was performed using STATA software version 18.0 to compare and rank exercises that could effectively improve the motor function of Parkinson’s disease patients (measured by indicators such as MDS-UPDRS-III, TUG, BBS, Mini-BES Test, 6MWT scores). Additionally, a series of analyses and evaluations were conducted, such as assessing the methodological quality of included studies using the Cochrane risk of bias tool.ResultsThe network meta-analysis included a total of 111 studies involving 5,358 participants, 133 intervention experiments, and 31 intervention measures. Although most exercise interventions showed effectiveness, cumulative ranking curves under the surface (SUCRA) values showed that archery exercise significantly improved patients’ MDS-UPDRS-III scores (SUCRA = 95.6%), significantly superior to routine care [standardized mean difference (SMD = 16.92, 95%CI = −28.97, −4.87)]. High-intensity and agility exercise (High strength and agility) referred to as high-intensity exercise or agility training or a combination of both, collectively termed as high-intensity agility training, significantly improved patients’ completion time for the time-up-and-go test (SUCRA = 99.7%), (SMD = −7.88, 95%CI = −9.47, −6.28). Dance and Tai Chi exercises significantly improved patients’ balance abilities: Mini-Balance Evaluation Systems Test (SUCRA = 77.9%), (SMD = 5.25, 95%CI = −0.42, 10.92) for dance intervention and Berg Balance Scale (SUCRA = 94.7%), (SMD = 11.22, 95%CI = 3.26, 19.18) for Tai Chi intervention. Dance also significantly improved patients’ walking ability in the 6-min walk test (SUCRA = 80.5%), (SMD = 71.31, 95%CI = 13.77, 128.84).ConclusionCompared to other exercises, archery, dance, Tai Chi, and high-intensity agility exercises demonstrate superior efficacy in improving the motor function of Parkinson’s disease patients.
Improvement in diagnostic-therapeutic care pathways for women with migraine: an Italian Delphi panel
Authors: Cevoli Sabina , Barbanti Piero , Finocchi Cinzia , Benedan Laura , Mariani Paolo , Orthmann Nicoletta , Bauleo Salvatore , Brusa Paola , Cianci Dorella , Marozio Luca , Masseroni Sara , Sangermani Roberto , Frediani Fabio , Allais Gianni 
Published: September 2024

BackgroundMigraine is a highly underestimated and burdensome disease. Real-world studies evidence that migraine is more frequent and severe in women than men. However, to this day, no diagnostic-therapeutic pathways exist to satisfy the specific needs of female patients.MethodsIn this study, migraine experts, specialists in women’s health, patient, and decision makers, analyzed the diagnostic and therapeutic options for women with migraine across various ages and health conditions within the Italian healthcare system. A Delphi approach was used to formulate statements and achieve a consensus.ResultsGaps in clinical practice were identified, and strategies to accommodate women’s needs were proposed. The experts agreed that a socio-behavioral intervention should be planned before any pharmacological treatment in pediatric/adolescent female patients and that the assessment of migraine with aura is considered crucial for adult women requiring contraceptive therapy. Acupuncture emerged as an effective treatment for pregnant and breastfeeding women, and hormone-replacement therapy selection in menopausal patients requires careful consideration to mitigate safety risks. The experts highlighted the absence of literature and guidelines for the management of migraine in women undergoing assisted reproductive procedures or oncological treatment. In light of these observations, the experts advocated the establishment of multidisciplinary collaborations between neurologists/headache specialists and other healthcare professionals, including general practitioners, pediatricians, gynecologists, and oncologists. Comprehensive migraine education for all healthcare professionals potentially involved in managing the disease, including pharmacists, was emphasized. Efforts to increase migraine awareness among women should be prioritized.ConclusionThe insights gained from this Italian consensus study should serve to develop an improved, female-specific pathway to diagnose and treat migraine.
The impact of accent stigma on self-efficacy and acculturation strategy among international students in the United States
Authors: Yan Xiaodi 
Published: September 2024

IntroductionThis paper aimed to understand international students’ experience of accent stigma during interpersonal interactions, and how it affected their self-efficacy and acculturation strategy during intercultural adjustment.MethodsStudy 1 conducted in-depth interviews with 15 international students (60% female, 21.6 years old on average), asking for narratives on how they perceived accent stigma was enacted in everyday scenarios. Study 2 distributed a survey to 132 international students (53.5% female, 25.52 years old on average) with scales measuring perceived accent stigma, perceived discrimination, perceived hate, fear, self-efficacy, and integration into the host culture.ResultsBased on thematic analysis, Study 1 identified verbal disapproval, verbal avoidance, nonverbal disapproval, and nonverbal avoidance as four behavioral markers that signal the enactment of accent stigma during interpersonal interactions. Study 2 assessed a path model and found that accent stigma was associated with more perceived discrimination, perceived hate, and fear. Accent stigma also had negative impacts on self-efficacy, which in turn, resulted in poor integration into the host culture.ConclusionThis study examined the negative consequences of accent stigma on international students and highlighted the role of self-efficacy during international students’ intercultural adjustment. Findings had important theoretical and practical implications in terms of better supporting and serving international students during their stressful transitional period in a new culture
The effect of subjective understanding on patients’ trust in AI pharmacy intravenous admixture services
Authors: Gong Yongzhi , Tang Xiaofei , Peng Haoyu 
Published: September 2024

IntroductionMedical services are getting automated and intelligent. An emerging medical service is the AI pharmacy intravenous admixture service (PIVAS) that prepares infusions through robots. However, patients may distrust these robots. Therefore, this study aims to investigate the psychological mechanism of patients’ trust in AI PIVAS.MethodsWe conducted one field study and four experimental studies to test our hypotheses. Study 1 and 2 investigated patients’ trust of AI PIVAS. Study 3 and 4 examined the effect of subjective understanding on trust in AI PIVAS. Study 5 examined the moderating effect of informed consent.ResultsThe results indicated that patients’ reluctance to trust AI PIVAS (Studies 1–2) stems from their lack of subjective understanding (Study 3). Particularly, patients have an illusion of understanding humans and difficulty in understanding AI (Study 4). In addition, informed consent emerges as a moderating factor, which improves patients’ subjective understanding of AI PIVAS, thereby increasing their trust (Study 5).DiscussionThe study contributes to the literature on algorithm aversion and cognitive psychology by providing insights into the mechanisms and boundary conditions of trust in the context of AI PIVAS. Findings suggest that medical service providers should explain the criteria or process to improve patients’ subjective understanding of medical AI, thus increasing the trust in algorithm-based services.
People with higher systemizing traits have wider right hands
Authors: Chen Na , Hidaka Souta , Ishii Naomi , Wada Makoto 
Published: September 2024

IntroductionVarious genetic mutations have been implicated in autism spectrum disorder (ASD). Some candidate genes for ASD are known to be related to signal transduction and may be involved in hand development as well as neurodevelopment. Therefore, although subtle, anatomical variations in hand configurations may be observed in individuals with ASD. However, except for research on the finger ratio, which has been suggested to be related to prenatal sex hormone exposure, only few studies have been conducted. Given the spectrum characteristics of ASD, we explored whether hand configurations are associated with ASD-related traits in the general population.MethodsPhotographs of the dorsal surface of each hand were obtained, and the distances between the metacarpophalangeal joints and finger lengths were measured. The Autism Spectrum Quotient, Empathy Quotient, and Systemizing Quotient were used to evaluate ASD-related traits.ResultsWe found a significant positive correlation between the aspect ratio of the right hand and the Systemizing Quotient score: individuals with a larger width relative to the finger length showed more systemizing traits.DiscussionThese findings suggest that gene polymorphisms or prenatal sex hormone exposure may underlie the relationship between systemizing traits and hand configurations.
Clinical features and outcomes of retroperitoneal unicentric Castleman disease resected as sarcomas: insights from a high-volume sarcoma center
Authors: Gao Haicheng , Li Wenjie , Zou Boyuan , Liu Shibo , Miao Chengli 
Published: September 2024

BackgroundCastleman disease (CD) is a rare lymphoproliferative disorder that can occur anywhere along the lymphatic pathway. Retroperitoneal unicentric Castleman disease (UCD) is an extremely rare manifestation. This study aims to explore the clinical features and surgical treatment of retroperitoneal UCD.MethodsWe retrospectively reviewed patients who underwent retroperitoneal tumor surgery and were diagnosed with CD based on postoperative pathology before December 31, 2022. Data from these patients were collected and analyzed.ResultsA total of 15 patients were included in the final analysis. All patients underwent radical resection under general anesthesia. Two out of 15 patients (13.3%) experienced serious complications but recovered well. There were no perioperative deaths. The median follow-up time was 78.5 months (range: 18–107.5 months), and no deaths or recurrences occurred during this period.ConclusionsSurgical treatment for retroperitoneal UCD is safe. Patients with retroperitoneal UCD can achieve long-time survival through complete resection.
Aryl Hydrocarbon Receptor Pathway Augments Peritoneal Fibrosis in a Murine CKD Model Exposed to Peritoneal Dialysate
Authors: Lotfollahzadeh Saran , Vazirani Aniket , Sellinger Isaac E. , Clovie Janelle , Hoekstra Isaac , Patel Arjun , Malloum Abbas Brahim , Yin Wenqing , Paul Herreet , Yadati Pranav , Siracus Jeffrey , Malikova Marina , Pernar Luise I. , Francis Jean , Stern Lauren , Chitalia Vipul C. 
Published: September 2024

Key Points

CKD and high glucose–containing peritoneal dialysate alter peritoneal membrane contributing to peritoneal dialysis failure, with a poorly understood mechanism.CKD milieu activates the aryl hydrocarbon receptor pathway in the subperitoneal vasculature, increasing the peritoneal fibrosis and collagen deposition in humans and mice.An aryl hydrocarbon receptor inhibitor mitigates CKD and peritoneal dialysis–mediated peritoneal fibrosis, collagen deposition, and vasculogenesis in a mouse model.

Background
CKD is a proinflammatory and profibrotic condition and can independently alter the peritoneal membrane structure. Peritoneal dialysis (PD) results in profound alterations in the peritoneal membrane. The mechanisms contributing to the alterations of the peritoneal membrane structure in CKD milieu, along with PD, are poorly understood.

Methods
Here, we show that human CKD induces peritoneal membrane thickening, fibrosis, and collagen deposition and activates the aryl hydrocarbon receptor (AHR) pathway in the subperitoneal vasculature. Leveraging a novel model of PD in CKD mice, we confirm these CKD-induced changes in the peritoneal membrane, which are exacerbated on exposure to the peritoneal dialysate. Peritoneal dialysate further augmented the AHR activity in endothelial cells of peritoneal microvasculature in CKD mice.

Results
Treatment of CKD mice with an AHR inhibitor in peritoneal dialysate for 2 weeks resulted in a seven-fold reduction in AHR expression in the endothelial cells of subperitoneal capillaries, a five-fold decrease in subperitoneal space, and a nine-fold decrease in fibrosis and collagen deposition compared with vehicle-treated CKD mice. AHR inhibition reduced inflammation, subperitoneal neovascular areas, and its downstream target, tissue factor. The AHR inhibitor treatment normalized the peritoneal dialysate-induced proinflammatory and profibrotic cytokines, such as IL-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein 1 levels, in CKD mice.

Conclusions
This study uncovers the activation of the AHR-cytokine axis in the endothelial cells of subperitoneal vessels in humans and mice with CKD, which is likely to prime the peritoneal membrane to peritoneal dialysate–mediated alterations. This study supports further exploration of AHR as a potential therapeutic target to preserve the structural and functional integrity of the peritoneal membrane in PD.
Major Customers and the Speed of Leverage Adjustments
Authors: Al-Thaqeb Saud A. 
Published: September 2024

Purpose: This study investigates how major customers influence the speed of adjustment (SOA) in a firm's capital structure, specifically examining the effects of governmental versus non-governmental major customers.Study design/methodology/approach: The study employs Blundell and Bond’s (1998) GMM model to estimate SOA. Robustness methods include fixed effects, two-stage least squares (2SLS), propensity score matching (PSM), and the augmented doubly censored Tobit (DPF estimator).Sample and data: The sample consists of 186,240 firm-year observations from Compustat North America annual files and Compustat historical segment files, spanning 1978 to 2013. Firms in the utility and financial sectors are excluded.Results: Findings indicate that major customers significantly influence SOA by reducing market uncertainty through certifications. Firms with major customers have a higher SOA, with governmental customers exhibiting an even higher SOA than non-governmental ones. Results are consistent across various models and settings.Originality/value: This study uniquely identifies major customers as critical determinants of SOA, highlighting the heterogeneities in firms' SOA. It stresses the importance of considering customer type in financial strategies, differentiating between governmental and non-governmental impacts. These findings offer valuable insights for scholars, policymakers, and practitioners.Research limitations/implications: Focusing on publicly listed U.S. firms limits generalization. Future research should extend the analysis to other regions and recent periods. The findings provide insights for supplier firms in strategizing financial decisions and managing relationships with major customers. We emphasize the significant role of major customers in financial strategies, advocating for more detailed disclosure policies in the U.S. and globally to enhance transparency and market efficiency.
КЫНДЫН ФЛОРАСЫНЫН СҮРТҮМҮНӨН ЖАНА ЖАТЫН МОЙУНЧАСЫНАН СУЮКТУКТАРЫНЫН ФИЗИКАЛЫК-ХИМИЯЛЫК КАСИЕТТЕРИНЕН ЖЫНЫС КЫНЫНЫН БАКТЕРИАЛДЫК СЕЗГЕНИЧИНИН ООРДУГУН БААЛОО ЖАНА ИШТЕП ЖАСАЛГАН ДАРЫЛАРДЫН АГА БОЛГОН ТААСИРИ
Authors: Уметалиева Д.Ю. , Сулайманова Н.Р. 
Published: September 2024

Бактериальный вагиноз (БВ) является наиболее распространенной причиной выделений из влагалища у женщин репродуктивного возраста. Распространенность БВ среди женщин репродуктивного возраста в общемировом масштабе составляет 23-29%. Нами проведено рандомизированное сравнительное клиническое исследование 45 женщин репродуктивного возраста больных бактериальным вагинозом. Для лечения женщин поделили на группы, где использовали: 1) электроактивированную воду (анолит) из скважины Чолпон-Атинского месторождения термальных минеральных вод; 2) влагалищные тампоны с разработанным флористически-солевым составом; 3) общепринятое лечение с антибиотиками. Исследование проводили на 2 и 14 день пребывания в санатории «Голубой Иссык-Куль». Микроскопическое исследование мазков влагалища подтверждают, что наибольшие положительные сдвиги отмечены при лечении бактериального вагиноза анолитом минеральной воды, а меньшие – антибиотиками, при лечении фитотампонами микроскопические показатели занимали среднее положение.
Бактериялык вагиноз (БВ) репродуктивдүү курактагы аялдардын кынынан патологиялык суюктук агышынын эң көп таралган себеби болуп саналат, репродуктивдүү курактагы аялдардын арасында БВдун глобалдык таралышы 23–29%. Биз бактериалдык вагинозу бар репродуктивдүү курактагы 45 аялга рандомизацияланган салыштырмалуу клиникалык изилдөө жүргүздүк. Дарылоо үчүн аялдар төмөнкүдөй топторго бөлүнгөн: 1) Чолпон-Ата термалдык минералдык суу кенинин скважинасынан алынган электрдик активдештирилген суу (анолит); 2) өнүккөн флористикалык-туздуу курамы бар кындын тампондору; 3) антибиотиктер менен кадимки дарылоо. Изилдөө аялдардын «Көгүлтүр Ысык-Көл» санаториясында 2 жана 14-күнүндө жатканында жүргүзүлгөн. Кындын флорасынын сүртүмүнүн изилдөөсү тастыктайт: эң чоң оң өзгөрүүлөр бактериялык вагинозду минералдык суу анолит менен дарылоодо белгиленген, азыраак таассир- антибиотиктер менен дарылангандарда, фитотампондор менен дарылоодо микроскопиялык көрсөткүчтөр орточо орунду ээлеген.
Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of reproductive age, with a global prevalence of BV among women of reproductive age of 23–29%. We conducted a randomized comparative clinical study of 45 women of reproductive age with bacterial vaginosis. For treatment, women were divided into groups where they used: 1) electrically activated water (anolyte) from the well of the Cholpon-Ata thermal mineral water deposit; 2) vaginal tampons with a developed floristic-salt composition; 3) conventional treatment with antibiotics. The study was carried out on the 2nd and 14th days of stay in the sanatorium. Microscopic examination of vaginal smears confirms that the greatest positive changes were noted when treating bacterial vaginosis with mineral water anolyte, and smaller ones with antibiotics; when treating with phytotampons, microscopic indicators occupied an average position.