bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS TEPUNG TEH DAN TEPUNG AMPAS TEH SEBAGAI FILLER PHENOL-FORMALDEHYDE RESIN TERHADAP KUALITAS PLYWOOD
Authors: Afrillia Ellysa Rahma , Sulha Balgis , Santosa Sandra , Prayitno Prayitno , Sulistio Any 
Published: September 2024

Hasil polimerisasi kondensasi antara phenol dengan formaldehyde disebut phenol-formaldehyde resin yang diaplikasikan untuk merekatkan lapisan veneer pada kayu lapis kelas eksterior. Bahan pengisi atau filler ditambahkan pada phenol-formaldehyde resin untuk meningkatkan keteguhan rekatnya. Bahan ini biasanya mengandung selulosa. Ditinjau dari kandungan selulosa yang cukup besar pada teh 34% dan ampas teh 43,87%, maka digunakan kedua bahan tersebut sebagai alternatif bahan pengisi (filler). Tujuan penelitian adalah untuk mengidentifikasi pengaruh kadar filler tepung teh dan tepung ampas teh terhadap viskositas phenol-formaldehyde resin serta pengaruhnya terhadap kualitas plywood. Penelitian dilakukan menggunakan metode pengempaan dingin selama 30 menit dan pengempaan panas dengan suhu 125°C selama 330 detik. Variabel tetap yang digunakan yaitu jenis veneer berupa kayu meranti, phenol-formaldehyde resin sebagai perekat, dan waktu pengadukan selama 5 menit. Sedangkan, variabel bebas yang digunakan adalah tepung ampas teh dan tepung teh sebagai filler dengan kadar 12,5% dan 6%. Efektivitas penambahan filler dinilai dari hasil analisis bonding strength dan delaminasi. Hasil penelitian menunjukkan bahwa kadar filler yang ditambahkan dapat meningkatkan viskositas campuran. Hasil bonding strength dan delaminasi menunjukkan bahwa tepung ampas teh dan tepung teh telah memenuhi JAS dengan nilai rata-rata tepung ampas teh yang lebih besar baik pada range viskositas 20-30 Poise (kadar filler 12,5%) dan 6-10 Poise (kadar filler 6%). Sehingga, tepung teh dan tepung ampas teh dapat dijadikan sebagi filler phenol-formalehyde resin.
Design and development of an IoT-based trolley for weighing the patient in lying condition
Authors: Meenatchi Sundaram S. , Naik Jayendra R. , Natarajan Manikandan , Acharya K Aneesha 
Published: September 2024

IntroductionAn immobile patient cannot be weighed on a stand-on weighing machine, i.e., a bathroom scale. They have to get weighed while lying, which is not easy. The main objective of this research is to design a medical apparatus that measures the patient's weight in a lying condition. To achieve this the apparatus is designed as a stretcher to carry the patient in and around the hospital.MethodsThe stretcher has four load cells to measure the patient's weight; it can bear a weight of 500 kg and has a self-weight of 20 kg. A Microcontroller unit (MCU) is embedded into the apparatus to weigh the patient lying on it. The stretcher comprises the top frame, middle frame, and base frame. The top frame can be detached and mounted back to the middle frame; this will help the medical personnel shift the patients from a medical bed. The middle frame is a plate structure where the four load cells are mounted at the corners of the lower plate. The upper plate functions as a pressure plate on the load cell. The base plate has four heavy-duty wheels that can bear the load. The middle frame and base frame, together, form a single structure, giving mobility to the structure. A control panel is employed with reset, tare, and on-off buttons to control the embedded platform. The LCD panel on the side of the apparatus shows the weight when the patient is placed on top of the apparatus.Results and discussionA prototype trolley equipped with a wireless data logging system was tested on 10 healthy participants. The device accurately measured weight within ±50 g across a scale range of 2–140 kg, with data captured every 30 s over a 5-min testing period. Wireless communication was successfully demonstrated over a 100-m range. The important add-on feature of this work is the apparatus is connected to the internet, transforming it into an IoT-based medical device.
Subtle yet encouraging developments: exploring intergroup relations between Arab and Jewish college students over seven years
Authors: Sindiani Mahmood , Hellerstein Devora , Sky Bosmat , Ben Zaken Sigal , Arnon Michal 
Published: September 2024

IntroductionThis study investigates the dynamics of intranational intergroup contact between Arab and Jewish students in a higher education institution in Israel. Guided by the contact hypothesis, the research examines the gap between students’ willingness for intergroup closeness and their reported actual intergroup interactions.MethodsUsing a cross-sectional survey design, quantitative data were collected from a total of 733 Arab and Jewish students at two timepoints: in 2016 (n = 419) and in 2023 (n = 314). All students were studying to become physical education teachers.ResultsThe findings revealed both persistent challenges and encouraging trends in intergroup relationships. Despite reported willingness for meaningful connections, the students’ reported actual intergroup interactions remained limited. A significant increase in willingness for academic and friendship relationships was observed from 2016 to 2023, suggesting the potential for constructive change. Arab students consistently reported higher willingness for closeness and more frequent interactions than their Jewish counterparts.DiscussionThese findings underscore the importance of structured interventions in higher education settings to foster meaningful intergroup relations, amidst broader societal challenges.
Changes in serum uteroglobin level in type 2 diabetes mellitus patients
Authors: Lim Joung Youl , Ju Sang-Hyeon , Kim Ji Min , Yi Hyon-Seung , Lee Ju Hee , Kim Hyun Jin , Ku Bon Jeong , Joung Kyong Hye 
Published: September 2024

BackgroundUteroglobin is a multifunctional protein with anti-inflammatory properties. Studies have revealed the importance of inflammation in type 2 diabetes mellitus (T2D) pathogenesis. Here, we investigated the relationship between uteroglobin and T2D.MethodsWe performed diagnostic tests for diabetes in subjects who had not been diagnosed with or treated for T2D. We established three groups, containing those with normal glucose tolerance (NGT), prediabetes and T2D, consisting of 80 people each, and compared their uteroglobin levels. In addition, 28 patients newly diagnosed with T2D were treated with metformin for 12 weeks, and 63 patients newly diagnosed with dyslipidaemia during the treatment for T2D were treated with statin for 12 weeks.ResultsThis study showed that uteroglobin levels were significantly lower in prediabetes and T2D groups than in the NGT group. Uteroglobin levels were not significantly correlated with other metabolic parameters, except BMI, HOMA-β and eGFR. In the group treated with metformin or statin, uteroglobin levels increased after treatment compared to before treatment.ConclusionsUteroglobin is a sensitive factor that was decreased even in prediabetes and increased upon treatment with drugs with anti-inflammatory effects. Uteroglobin is a potential early biomarker that reflects a chronic inflammatory condition in T2D.
Rethinking the prognosis model of differentiated thyroid carcinoma
Authors: He Liang , Xiang Jingzhe , Zhang Hao 
Published: September 2024

BackgroundThe prediction efficiency of long-term cancer-specific survival (CSS) in guiding the treatment of differentiated thyroid carcinoma (DTC) patients is still unsatisfactory. We need to refine the system so that it more accurately correlates with survival.MethodsThis is a retrospective study using the Surveillance, Epidemiology, and End Results (SEER) database, and included patients who underwent surgical treatment and were diagnosed with DTC from 2004 to 2020. Patients were divided into a training cohort (2004–2015) and validation cohort (2016–2020). Decision tree methodology was used to build the model in the training cohort. The newly identified groups were verified in the validation cohort.ResultsDTC patient totals of 52,917 and 48,896 were included in the training and validation cohorts, respectively. Decision tree classification of DTC patients consisted of five categorical variables, which in order of importance were as follows: M categories, age, extrathyroidal extension, tumor size, and N categories. Then, we identified five TNM groups with similar within-group CSS. More patients were classified as stage I, and the number of stage IV patients decreased significantly. The new system had a higher proportion of variance explained (PVE) (5.04%) and lower Akaike information criterion (AIC) (18,331.906) than the 8th TNM staging system (a PVE of 4.11% and AIC of 18,692.282). In the validation cohort, the new system also showed better discrimination for survival.ConclusionThe new system for DTC appeared to be more accurate in distinguishing stages according to the risk of mortality and provided more accurate risk stratifications and potential treatment selections.
Prevention and alleviation of allergic rhinitis by oral administration of Lacticaseibacillus paracasei GOLDGUT-Lpc969
Authors: Zhou Xiaoli , Song Xizi , Shu Ting , Zhang Silu , Zhang Zhizhu , Hu Canying , Pan Jie , Dai Xiaoshuang , Hao Huaijie , Xiao Guoxun , Wang Pengfei , Liu Kai 
Published: September 2024

IntroductionAllergic rhinitis (AR) is a widespread upper airway disorder characterized by inflammation of the nasal passages. It is immunologically mediated via the hypersensitivity type I mechanism, which is primarily elicited by the immunoglobulin E (IgE)-linking allergen-induced imbalance of the Th2/Th1 immune response. Owing to the limited efficacy of current medications, probiotics have received attention for their potential in preventing and ameliorating AR.MethodsIn this study, a Lacticaseibacillus paracasei strain, GOLDGUTLpc969 (Lpc969), isolated from the feces of healthy adults, was proven to be effective in preventing AR by LPA-induced RBL-2H3 in-vitro and OVA-induced AR mice in-vivo evaluation.ResultsThe strain significantly attenuated the release of histamine and degranulation in LPS-induced RBL-2H3 cells. In the OVA-induced AR mice, L. paracasei GOLDGUT-Lpc969 also exhibited a significant decrease in disease indicators such as the disease activity index (DAI score), serum IgE, and serum histamine. Treatment with L. paracasei GOLDGUT-Lpc969 led to significant suppression of the Th2-related cytokines IL-4, IL-5, IL-6, IL-13, and TNF-α in the serum of mice.DiscussionFurthermore, a comparison of the genomes of three previously reported AR-effective L. paracasei strains (including GOLDGUTLpc969) and one non-effective L. paracasei strain revealed that the gene K03671 may play a key role in alleviating AR symptoms. In conclusion, this study highlights the efficacy of L. paracasei GOLDGUT-Lpc969 in AR prevention by suppressing the Th2 immune response and proposes the potential involvement of the functional gene K03671 in ameliorating AR symptoms. Therefore, L. paracasei GOLDGUT-Lpc969 shows promise as a probiotic for preventing AR.
U-Net-based computed tomography quantification of viral pneumonia can predict fibrotic interstitial lung abnormalities at 3-month follow-up
Authors: Ying Zhoumeng , Zhu Zhenchen , Hu Ge , Pan Zhengsong , Tan Weixiong , Han Wei , Wu Zifeng , Zhou Zhen , Wang Jinhua , Song Wei , Song Lan , Jin Zhengyu 
Published: September 2024

BackgroundGiven the high prevalence of fibrotic interstitial lung abnormalities (ILAs) post-COVID-19, this study aims to evaluate the effectiveness of quantitative CT features in predicting fibrotic ILAs at 3-month follow-up.MethodsThis retrospective study utilized cohorts from distinct clinical settings: the training dataset comprised individuals presenting at the fever clinic and emergency department, while the validation dataset included patients hospitalized with COVID-19 pneumonia. They were classified into fibrotic group and nonfibrotic group based on whether the fibrotic ILAs were present at follow-up. A U-Net-based AI tool was used for quantification of both pneumonia lesions and pulmonary blood volumes. Receiver operating characteristic (ROC) curve analysis and multivariate analysis were used to assess their predictive abilities for fibrotic ILAs.ResultsAmong the training dataset, 122 patients (mean age of 68 years ±16 [standard deviation], 73 men), 55.74% showed fibrotic ILAs at 3-month follow-up. The multivariate analysis identified the pneumonia volume [PV, odd ratio (OR) 3.28, 95% confidence interval (CI): 1.20–9.31, p = 0.02], consolidation volume (CV, OR 3.77, 95% CI: 1.37–10.75, p = 0.01), ground-glass opacity volume (GV, OR 3.38, 95% CI: 1.26–9.38, p = 0.02), pneumonia mass (PM, OR 3.58, 95% CI: 1.28–10.46, p = 0.02), and the CT score (OR 12.06, 95% CI: 3.15–58.89, p &lt; 0.001) as independent predictors of fibrotic ILAs, and all quantitative parameters were as effective as CT score (all p &gt; 0.05). And the area under the curve (AUC) values were PV (0.79), GV (0.78), PM (0.79), CV (0.80), and the CT score (0.77). The validation dataset, comprising 45 patients (mean age 67.29 ± 14.29 years, 25 males) with 57.78% showing fibrotic ILAs at follow-up, confirmed the predictive validity of these parameters with AUC values for PV (0.86), CV (0.90), GV (0.83), PM (0.88), and the CT score (0.85). Additionally, the percentage of blood volume in vessels &lt;5mm2 relative to the total pulmonary blood volume (BV5%) was significantly lower in patients with fibrotic ILAs (p = 0.048) compared to those without.ConclusionU-Net based quantification of pneumonia lesion and BV5% on baseline CT scan has the potential to predict fibrotic ILAs at follow-up in COVID-19 patients.
Expression of stress responsive genes enables Limosilactobacillus reuteri to cross-protection against acid, bile salt, and freeze-drying
Authors: Liu Zhenzhen , Zhao Xiao , Bangash Hina Iqbal 
Published: September 2024

IntroductionLimosilactobacillus reuteri effectively colonizing the gut, secretes antimicrobial compounds and strengthens immune system function. Considering these health benefits, increasing its stress assessments efficiency could improve its commercial viability.MethodsIn this work, the resistance of L. reuteri FP41 to acid, bile salts, and freeze-drying was examined.ResultsThe findings showed that strain FP41 demonstrated a strong resistance to acid/bile salt stresses. The transcriptome revealed a significant up-regulation of various stress response genes, including those related to membrane integrity, glutamine metabolism, OsmC family protein, ABC transporters, and chaperonin. Subsequent research demonstrated that overexpression of three stress response-specific proteins, including glutamate decarboxylase GatD, osmotically induced bacterial protein OsmC, and membrane protein component CsbD, significantly increased the survival rate of L. reuteri Z204 under acid/bile salts stress. Notably, overexpression of the OsmC, CsbD, and GatD proteins also enhanced the survival of L. reuteri after freeze-drying.DiscussionThe development of a unique cross-protection method is highlighted in this study, that might significantly increase cellular resistance to acid, bile salts, and cold stresses. This finding could significantly impact the way that L. reuteri is employed in industrial manufacturing processes.
Analysis of the correlation between Hashimoto’s thyroiditis and food intolerance
Authors: Yan Manli , Wu Hai , Zhang Kaiyuan , Gong Ping , Wang Yiting , Wei Hua 
Published: September 2024

ObjectiveThis study aims to explore the correlation between patients with Hashimoto’s thyroiditis and food intolerance.MethodsA total of 172 subjects who visited Guangdong Provincial Hospital of Traditional Chinese Medicine between January 2020 and March 2023 were selected and tested for 90 food-specific IgG antibodies. The study group composed 85 individuals diagnosed with Hashimoto’s thyroiditis, while the control group consisted of 87 healthy individuals. Data were analyzed to determine the correlation between Hashimoto’s thyroiditis and food intolerance.ResultsAmong the 85 patients with Hashimoto’s thyroiditis, 97.65% exhibited food intolerance, with an average of 15.76 ± 10.61 types of food intolerances. The most common intolerances were to eggs (75.29%), bok choy (71.76%), and milk (65.88%), each exceeding a 60% intolerance rate. In the control group of 87 healthy individuals, the intolerance rate was 95.40%, with an average of 9.57 ± 8.90 types of food intolerances. The most prevalent intolerances in the control group were to bok choy (54.02%) and eggs (52.87%), each exceeding a 50% intolerance rate.ConclusionThe findings suggest that patients with Hashimoto’s thyroiditis are more likely to develop food intolerance compared to the healthy population, which may indicate a correlation between Hashimoto’s thyroiditis and food intolerance. Different dietary patterns may affect the activity of the thyroid axis and may even be the cause of autoimmune thyroid disease. The technique of detecting food intolerance IgG antibodies has the potential to be an important reference for dietary interventions in patients with Hashimoto’s thyroiditis.
Evaluating the feasibility and predictive accuracy of biodynamic imaging to platinum-based chemotherapy response in esophageal adenocarcinoma
Authors: Ajrouch Ali , Krempley Ben , Karkash Ahmad , Dewitt John M. , Al-Haddad Mohammad , Lim Dawith , Nolte David , Turek John , Perkins Susan M. , Jalal Shadia I. 
Published: September 2024

BackgroundEsophageal cancer management lacks reliable response predictors to chemotherapy. In this study we evaluated the feasibility and accuracy of Biodynamic Imaging (BDI), a technology that employs digital holography as a rapid predictor of chemotherapy sensitivity in locoregional esophageal adenocarcinoma.MethodsPre-treatment endoscopic pinch biopsies were collected from patients with esophageal adenocarcinoma during standard staging procedures. BDI analyzed the tumor samples and assessed in vitro chemotherapy sensitivity. BDI sensitivity predictions were compared to patients’ pathological responses, the gold standard for determining clinical response, in the surgically treated subset (n=18).ResultBDI was feasible with timely tissue acquisition, collection, and processing in all 30 enrolled patients and successful BDI analysis in 28/29 (96%) eligible. BDI accurately predicted chemotherapy response in 13/18 (72.2%) patients using a classifier for complete, marked, and partial/no-response. BDI technology had 100% negative predictive value for complete pathological response hence identifying patients unlikely to respond to treatment.ConclusionBDI technology can potentially predict patients’ response to platinum chemotherapy. Additionally, this technology represents a promising step towards optimizing treatment strategies for esophageal adenocarcinoma patients by pre-emptively identifying non-responders to conventional platinum-based chemotherapy.
Enhancing chronic low back pain management: an initial neuroimaging study of a mobile interoceptive attention training
Authors: Strigo Irina A. , Guerra Sergio Garcia , Torrisi Salvatore , Murphy Emily , Toor Tiffany , Goldman Veronica , Alter Benedict J. , Vu An Thanh , Hecht Rich , Lotz Jeff , Simmons Alan N. , Mehling Wolf E. 
Published: September 2024

IntroductionChronic low back pain (cLBP) poses significant challenges, often addressed through avoidance or distraction. Emerging evidence suggests that mind-body interventions, like our novel Mind Your Pain (MyP) smartphone mobile application, may offer relief. We conducted a single-arm, mixed-methods neuroimaging study to assess the degree to which treatment response to our 8-week intervention, as measured by the reduction in the Pain, Enjoyment of Life and General Activity Scale (PEG), was associated with enhanced pain-related insula activation over time.MethodsTwenty-nine individuals with cLBP completed patient-reported assessments, qualitative sensory testing (QST) measures, and neuroimaging pre- and post-MyP. Functional MRI data during experimental heat pain on the left forearm were collected and analyzed, comparing responders (≥50% reduction in PEG scores) and non-responders.ResultsMyP led to significant decreases in PEG scores overall. Furthermore, MyP responders exhibited increased pain-related activation in key brain regions, including the contralateral posterior insula, bilateral ventral anterior insula, ventral anterior cingulate, dorsolateral prefrontal cortex, and nucleus accumbens. Although baseline behavioral and sensory measures did not differ between the two responder groups, baseline neural differences related to the impact of the endogenous back pain were observed.DiscussionMyP appears to modify pain response and underlying neural circuitry, suggesting neural changes in interoception may serve as biomarkers for mind-body interventions in cLBP. This study highlights the potential of MyP as a novel approach for cLBP management, warranting further investigation.
Natural products for the treatment of allergic rhinitis: focus on cellular signaling pathways and pharmacological targets
Authors: Moradi Shabnam , Khazaei Hosna , Tarlan Mitra , Jasemi Seyed Vahid , Joshi Tanuj , Aneva Ina Yosifova , Farzaei Mohammad Hosein , Echeverría Javier 
Published: September 2024

BackgroundAllergic rhinitis is an inflammatory disease dependent on immunoglobulin E and causes inflammation of the nasal mucosa, leading to decreased quality of life for affected patients. Since common treatments, including corticosteroids and antihistamines, have temporary therapeutic effects and numerous side effects, investigating natural compounds effective in improving allergic rhinitis with low complications and high efficacy can be significant and necessary.PurposeThis study aims to present a comprehensive and critical evaluation of the effect of natural compounds in improving allergic rhinitis.MethodsStudies were identified through systematic searches of ScienceDirect, PubMed, Scopus, and Web of Sciences databases. Eligibility checks were conducted based on predefined selection criteria. Forty-six articles were included in this study.Results and discussionPhytochemicals, including flavonoids, alkaloids, terpenoids, and other compounds showed significant anti-inflammatory and antihistaminic effects. These compounds alleviate allergic rhinitis symptoms by inhibiting inflammatory mediators, oxidative stress, apoptosis, and key signaling pathways such as MAPK/NFκB and TLR4/MyD88/NF-κB.ConclusionPhytochemicals exhibit anti-inflammatory and antioxidant properties, making them.