bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESG and firm performance: The effects of foreigners on board and export orientation
Authors: Wu Chen‐Hui , Nguyen Thi‐Kim‐Tuyen 
Published: October 2024

AbstractThis study investigates whether environmental, social, and governance (ESG) disclosures enhance industry‐adjusted firm performance and whether the presence of foreigners on board and export orientation affect this relationship. The Taiwan dataset from 2013 to 2020 indicates that ESG practices positively affect accounting‐ and market‐based performance (i.e., adjusted Tobin's Q and adjusted MTB ratio). However, ESG has no significant relationship with purely market‐based performance (i.e., adjusted Jensen Alpha and adjusted FF3). The results illustrate a significant joint effect of ESG with foreigners on board and export experience on accounting and market‐based performance. The findings provide deeper insight into the complex relationship between sustainability practices, ownership structures, and international businesses. Our findings remain consistent when using alternative estimation methods to account for endogeneity and selection bias.
Research and innovation of the “ship navigation radar” course based on the four‐in‐one approach in engineering education accreditation
Authors: Jingjing Lian , Xiao Yang , Delong Wang 
Published: October 2024

AbstractTo achieve the strategic goal of marine and transportation power, it is imperative to cultivate highly skilled navigation professionals with a strong theoretical foundation and practical expertize. Seizing the opportunity by the “Double Thousand Plan” first‐class undergraduate courses initiated by the Ministry of Education, a four‐in‐one experimental teaching model is developed for ship navigation radar courses that integrate virtual reality technology under the context of engineering certification. The model encompasses land laboratory real training, maritime radar simulator training platform, comprehensive real‐ship training at sea, and virtual laboratory teaching and training. Through this innovative approach, students can acquire essential knowledge of ship navigation radar required for practical activities in navigation practice while honing their operational skills in positioning, navigation, and collision avoidance using radars. Furthermore, an analysis of course attainment and future development trends is conducted to provide insights into enhancing maritime education and fostering internationally competitive shipping talents.
Sources of meaning and hope and associated well‐being among psychotherapy clients: A practice‐based mixed method study
Authors: Captari Laura E. , Guterres Karley , Oleson Dottie , Devor Nancy , Sandage Steven J. 
Published: October 2024

AbstractBackgroundDespite the recognition of meaning and hope as salient for many individuals in mental health treatment, little empirical attention has been given to patient perspectives. Research has primarily looked at the presence—or absence—of meaning and hope, and associations with symptom distress and suicidality.AimsThese constructs are multi‐faceted and influenced by social, cultural and spiritual/religious contexts. Understanding where clients draw meaning and hope from can provide valuable information to inform case formulation, treatment planning and intervention.Materials and MethodsThis mixed method practice‐based study (N = 233) in an outpatient community clinic (a) elucidated key areas that fuel clients' sense of meaning and hope and (b) explored associations with well‐being.ResultsQualitatively, we identified six domains through thematic analysis: interpersonal, action‐based, transcendent, intrapersonal, environmental/contextual and lacking/searching. A sub‐set of clients also emerged who were lacking in and/or searching for meaning or hope. Quantitatively, one‐way ANOVA results indicated that source diversity was associated with greater well‐being.DiscussionFindings illustrate that patients draw from culturally and spiritually embedded sources to construct meaning and hope in their lives, with distinctions between areas most salient for meaning, hope and both. Furthermore, having fewer sources of meaning and/or hope may represent a well‐being liability.ConclusionTherapists should pro‐actively explore and consider ways to bolster patients' sources of meaning and hope, considering evidence of implications for well‐being outcomes.
Structure‐Activity Relationship of 7‐Chloro‐4‐(Phenylselanyl) Quinoline: Novel Antinociceptive and Anti‐Inflammatory Effects in Mice
Authors: da Rocha Vanessa M. E. , da Motta Ketlyn P. , Martins Carolina C. , Lemos Briana B. , Larroza Allya , Morais Roberto B. , Steinhorst Rodrigo K. , Roehrs Juliano A. , Alves Diego , Luchese Cristiane , Wilhelm Ethel A. 
Published: October 2024

AbstractThe 7‐chloro‐4‐(phenylselanyl) quinoline (4‐PSQ) shows promise for its antinociceptive and anti‐inflammatory properties. Here, we explored the structure‐activity relationship of 4‐PSQ and its analogues: 7‐chloro‐4‐[(4‐fluorophenyl) selanyl]quinoline (a), 7‐chloro‐4‐{[3‐trifluoromethyl)phenyl] selanyl} quinoline (b), 4‐((3,5‐Bis(trifluoromethyl)phenyl) selanyl‐7‐chloroquinoline (c), 7‐chloro‐4‐[(2,4,6‐trimethyl)selanyl]quinolinic acid (d) and 7‐chloroquinoline‐4‐selenium acid (e) in models of acute inflammation and chemical, thermal and mechanical nociception in mice, alongside in silico analysis. Compounds a (−F), b (−CF3), c (−Bis‐CF3), d (−CH3), e (−OOH), and 4‐PSQ exhibited antinociceptive effects in chemical and thermal nociception models, except d (−CH3) and e (−OOH) in the hot plate test. None induced locomotor changes. In silico, only c (−Bis‐CF3) showed low gastrointestinal absorption, and c (−Bis‐CF3) and e (−OOH) lacked blood‐brain barrier penetration, suggesting e (−OOH) lacked central antinociceptive effect. These compounds had higher COX‐2 affinity than COX‐1. Our findings suggest substituent insertion alters 4‐PSQ's efficacy as an antinociceptive and anti‐inflammatory agent.
Hydralazine and Hydrazine Derivatives: Properties, Applications, and Repositioning Potential
Authors: Romão Ivana Carneiro , Siqueira Sônia Maria Costa , Silva Abreu Flávia Oliveira Monteiro da , Santos Hélcio Silva dos 
Published: October 2024

AbstractThe investigation of new drugs is slow and costly. Drug repositioning, like with Hydralazine (HDZ), an old antihypertensive, can accelerate the process. HDZ and its hydrazonic derivatives exhibit diverse biological activities, promising for new drugs. This review explores HDZ's repositioning potential and its derivatives’ applications in various biological activities. It identified 70 relevant articles through database searches. HDZ shows potential in neurology, oncology, nephrology, and gynecology, with clinical trials up to Phase III. Hydralazine‐valproate, marketed in Mexico, proves effective in combination with chemotherapy. Hydrazonic derivatives offer broad applications in medicine. Studying their structure‐activity relationship can enhance efficacy. This review summarizes their properties and pharmacological activities succinctly.
MARCHF1 promotes breast cancer through accelerating REST ubiquitylation and following TFAM transcription
Authors: Li Jutao , Gao Zhenming 
Published: October 2024

AbstractBreast cancer has become the leading cause of death in women. Membrane associated ring‐CH‐type finger 1 (MARCHF1) is associated with the development of various types of cancer, but the exact role of MARCHF1 in breast cancer remains unclear. In our study, the higher MARCHF1 expression was observed in tumor samples of patients with breast cancer and then the role of MARCHF1 in breast cancer was further evaluated. Overexpression of MARCHF1 contributed to proliferation of cancer cells and inhibition of oxidative stress. Knockdown of MARCHF1 reduced breast cancer cell proliferation, increased mitochondrial dysfunction induced by oxidative stress, eventually aggravating cell death. In vivo, MARCHF1 promoted the tumor growth and oppositely, MARCHF1 silencing suppressed the tumor development. Moreover, MARCHF1 interacted with repressor Element‐1 silencing transcription factor (REST) and facilitated its ubiquitylation and degradation. Subsequently, REST negatively regulated the transcription of mitochondrial transcription factor A (TFAM). The subcutaneous tumor formation assay in nude mice also supported these conclusions. In details, knockdown of MARCHF1 upregulated the protein expression of REST and downregulated the mRNA level of TFAM. On the contrary, MARCHF1 overexpression exhibited opposite effects. Thus, MARCHF1 is conducive to the progression of breast cancer via promoting the ubiquitylation and degradation of RSET and then the transcription of TFAM. Downregulating MARCHF1 could provide a novel direction for treating breast cancer.
Lithium Demand and Cyclability Trade‐Off in Conductive Nanostructure Scaffolds in Terms of Different Tortuosity Parameters
Authors: Ali Hoseini Seyed , Mohajerzadeh Shams , Sanaee Zeinab 
Published: October 2024

AbstractThrough alteration of the polarity of DC plasma during the growth of carbon nanotubes in a PECVD reactor, significantly different morphologies of such species have been achieved. By using this approach, for the first time, both Half‐aligned and Entangled structures were synthesized, along with Full‐aligned carbon nanotubes, introducing three binder‐free electrodes with various levels of tortuosity. The crucial parameter and influential effect of tortuosity in these three‐dimensional nanostructure scaffolds for application in lithium‐ion batteries were investigated. Previous research findings suggested that increasing the tortuosity of the conductive scaffolds leads to preferential accumulation of lithium at the top surface and causes the loss of capacity in subsequent charge‐discharge cycles. Our finding reveals that there exists a trade‐off between lithium‐demand, capacity, and preferential accumulation of lithium at the top surface. Among the presented scaffolds, the Half‐aligned MWCNTs was able to maintain a high capacity of 876.9 mAh/g over more than 300 cycles, and demonstrate capacity improvement during this period and excellent rate capability, even at a rate of 5 C. This capacity is almost three times that can be achieved with graphite, showcasing promising and outstanding results for carbon nanotubes.
Generation of Murine Cancer Cell Lines
Authors: Zhang Cheryl , Lin Anthony , Chen Xiang , Du Yi‐Chieh Nancy 
Published: October 2024

AbstractCancer cell lines are important tools to investigate the biology of cancer and test hypotheses to improve cancer treatments. A major challenge in establishing epithelial cancer cell lines is the removal of cancer‐associated fibroblasts (CAFs). CAFs are abundant within the tumor microenvironment. CAFs generally proliferate faster than epithelial cancer cells in culture. CAFs can be mistakenly identified as cancer cells, especially when cancer cells display spindle‐shaped morphology. Among all cancer types, pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic stroma. Here, we describe protocols for establishing epithelial cancer cell lines from mouse models of PDAC and verifying that they are not CAFs. The approach is cost‐effective and can be used for other types of cancer. If needed, CAF cell lines can also be established and preserved using this protocol. © 2024 Wiley Periodicals LLC.Basic Protocol 1: Isolation of cells from tumorsBasic Protocol 2: Isolation and cryopreservation of cancer cell clonesBasic Protocol 3: Assessment of the identity of cancer cell lines and CAFs by western blotting
Defense strategies against sweet potato chlorotic stunt and pakakuy virus coinfection unraveled
Authors: Kiemo Francis Wanjohi , Salamon Pál , Tóth Zoltán , Szabó Zoltán 
Published: October 2024

AbstractThis study into the response of two Ipomoea batatas (L.) Lam cultivars, Melinda and Tio Joe, to coinfection with sweet potato chlorotic stunt virus (SPCSV) and sweet potato pakakuy virus (SPPV), employed a comprehensive approach encompassing symptomatology, real‐time quantitative polymerase chain reaction, metagenomics, and transcriptomics. SPCSV is a quarantine virus with synergistic effects, which decimate yields. SPPV is the most prevalent DNA virus in sweet potato germplasm, with a tendency to persist in meristems, posing a significant risk for germplasm transfer between territories. Graft inoculation experiments revealed that while Tio Joe remained asymptomatic for 12 weeks and suppressed virus replication, Melinda displayed symptoms early on and exhibited high virus titers. Metagenomic analyses corroborated these observations and confirmed that SPCSV and SPPV were responsible. Transcriptomic analysis unveiled disparities in gene expression between Melinda and Tio Joe. Differential gene expression was heightened and altered in Melinda as the viruses disrupted its gene expression. Its defense strategies, such as inducing abscisic acid signaling, were insufficient to overcome disruptive viral effects like oxidative stress, rendering it susceptible. In contrast, Tio Joe had relatively stable differential gene expression, indicating resistance to SPPV–SPCSV coinfection. Overexpressed genes such as sirtuin, rapid alkalization factor, and nuclear pore anchor triggered quantitative resistance, supported with enriched organelles such as mitochondrion and pathways such as proteasome and cutin, suberine, and wax biosynthesis. Tio Joe maintained its genome integrity and inhibited viral replication by tightly controlling gene expression and preventing reactive oxygen species accumulation.
Cascaded AC–DC Voltage Control to Provide Reactive Power Support for the PV‐Driven Grid‐Tied Synchronverter
Authors: S Pandey Amarjeet , Kallamadi Manjunath , Shah Krupa 
Published: October 2024

ABSTRACTThe objective of this submission is to provide flexible reactive power regulation of a photovoltaic (PV)‐driven grid‐connected inverter. Here, inverter is realized as a synchronverter by employing frequency regulation using well‐established swing equation. However, reactive power regulation is accomplished by employing combined AC–DC voltage control in addition to traditional synchronverter control for ensuring smooth tracking of reactive power. Thus, the PV‐driven voltage source converter (VSC) will be injecting available active power as per the prevailing irradiation, temperature, and operator defined reactive power by employing proposed control. The performance of suggested control is evaluated and compared against existing control by considering realistic operational scenarios through a case study.
A Direct Conversion Frontend With Bandwidth Extension and Linearity Enhancement for 5G Receivers
Authors: Rahmani Adibeh , Mojarad Mortaza 
Published: October 2024

ABSTRACTIn this paper, a new frontend for 5G receivers is proposed. In the presented work, a new bandwidth enhancement technique for low‐noise transconductance amplifiers and for wireless frontends has been proposed. The proposed frontend achieves low noise figure (NF) by using a noise cancelation scheme in the newly proposed LNTA. The linearity of the frontend is also improved by increasing the DC gain and the bandwidth of the opamp used in the transimpedance amplifier and by exploiting a linearity improvement method for the LNTA. The frontend has been implemented in a standard 0.18 μm CMOS process. The post‐layout simulation results prove the gain of 38 dB with less than 3 dB deviation in the pass‐band over a 6.5 GHz bandwidth. The results also show that NF is less than 8 dB, the worst‐case IIP3 is −2 dBm, the maximum S11 is equal to −9.5 dB while the frontend consumes 9.95 mW DC power from a single 1.8‐V supply, and the occupied area is 0.813 mm2.
Testing the fidelity of zircon as a provenance indicator in fluvial‐fan successions: An example from the Palaeogene Colton Formation, Central Utah, USA
Authors: Carraro Davide , Gaynor Sean P. , Ventra Dario , Ulyanov Alexey , Moscariello Andrea 
Published: October 2024

AbstractThe stratigraphic, spatial and temporal variability of detrital zircon age populations in continental sedimentary successions is a critical tool in understanding palaeodrainage networks and how these systems distributed detritus within sedimentary basins. However, multiple factors, such as variations in sediment‐transport processes, the scale of the depositional environment and the architecture of the sedimentary succession are often overlooked in detrital zircon studies. This article presents detrital zircon U–Pb geochronology from the fluvial‐dominated Colton Formation in the western Uinta Basin (Utah, USA) to assess the system's provenance and evolution. Significant differences in zircon age populations between the Colton Formation and the overlying Green River Formation suggest a reorganisation of the source‐to‐sink system during the transition between the two lithostratigraphic units. Notably, detrital zircon age spectra are not homogeneous across the Colton Formation, therefore physical morphometric parameters were used to verify the possible influence of selective bias during sediment transport. These data reveal that a relatively finer‐grained population of Precambrian, and to a less extent Mesozoic, zircon grains were affected by hydraulic sorting during transport, resulting in a greater relative abundance of older zircon grains in the distal reaches of the distributive fluvial system, whose basinward decrease in competence would have increased the relative proportion of finer zircon fractions in sandstones. Furthermore, there are different trends in the distributions of zircon age populations relative to their stratigraphic position, highlighting the complex architecture of the fluvial palaeo‐fan. The spatial and stratigraphic variability of provenance signals in fluvial‐fan successions must be carefully evaluated to improve the reliability of source‐to‐sink models and palaeodrainage reconstructions, as autogenically controlled noise can be generated during the dispersal of detrital zircon in fluvial sedimentary systems.
Taking Steps Toward a Consensus on Night Eating Syndrome Diagnostic Criteria
Authors: Weissman Ruth Striegel , Martin‐Wagar Caitlin A. , Attaway Sarah , Penwell Taylor , Hogan Ava , Pruscino Isabella 
Published: October 2024

ABSTRACTBackgroundNight eating syndrome (NES) is included in the Diagnostic and Statistical Manual for Mental Disorders, 5th edition, as an example of “Other Specified Feeding or Eating Disorders” with minimal guidance about how to define and operationalize NES. The literature suggests that research practices vary widely, making it difficult to draw conclusions about the public health burden of, effective interventions for, or policy implications relevant to NES. This Forum article seeks to illustrate the lack of definitional agreement to underscore the need for a consensus about NES diagnostic criteria, and to propose steps toward closing knowledge gaps and achieving consensus.MethodWe searched PubMed and PsycINFO titles and abstracts, using “NES” as the search term, for research articles published in English between January 1, 2013 to August 12, 2024 with sample sizes of NES > 10 and ages 18 or older. Eligible articles were coded for NES definitions and assessment method used to diagnose participants with NES and for information about comorbidity of NES and any other eating disorder (ED).ResultsSeventy‐three articles met inclusion criteria. Most commonly, NES was diagnosed using a diagnostic criteria set (35/73) or a symptom score threshold (34/73); among the former, only eight studies employed DSM‐5 NES criteria. Thirteen studies, varying widely in methodology, examined comorbidity with other EDs, most commonly binge‐eating disorder where comorbidity was high.ConclusionHeterogeneity of definitions and assessment impede progress in the study of NES. We propose strategies for developing a consensus definition and addressing research gaps.
Andrographolide Encapsulation in Metal‐Organic Frameworks (MOFs) via Solvent‐Free Process at High Pressure
Authors: Pantoja‐Romero Wenndy , Aysa‐Martínez Yolanda , Lavín‐Flores Alexis , Medina‐Berrios Nataniel , Bayro Marvin J. , Morell Gerardo , Weiner Brad R. , Coronas Joaquín 
Published: October 2024

AbstractAndrographolide (ADG) encapsulation was carried out on MOFs MIL‐53(Al) and ZIF‐8 by high‐pressure (0.3 GPa) contact. This methodology is not only environment‐friendly but also energy/time‐saving and gives rise to ADG‐MOFs with physical features equivalent to those of materials obtained by common liquid phase encapsulation. The loaded MOFs were characterized through TEM, SEM, XRD, TGA, FT‐IR, BET, and NMR. The observed decrease in the intensity of ADG XRD peaks is due to the adsorption of ADG into the MOFs. TGA showed the decomposition step of ADG in the range of 200–300 °C in both loaded MOFs. FT‐IR also showed intense signals of the ADG in the synthesized materials. The dissolution profile of ADG in MIL‐53(Al) in PBS (pH=7.4) was carried out showing that the drug was released up to 96 % after 75 h. Solid‐state NMR confirmed the interactions between ADG molecules and ZIF‐8 groups and the formation of a hydrogen bond between the carboxylic group of ADG and the hydroxyl group of MIL‐53(Al). Coefficient partition studies determined that both MOFs did not improve the hydrophilicity of the ADG, due to the loading of the drug preferably occurring by interactions in the hydrophobic areas within the pores of the MOFs.
A Theoretical and Experimental Investigation of the Effects of Inverted Wings Modifications on the Stability and Aerodynamic Performance of a Sedan Car at Cornering
Authors: Abood Mustafa Sabeeh , Hussain IhsanYahya , Ali Anmar Hamid 
Published: October 2024

ABSTRACTThis research examines the impact of cornering on the aerodynamic forces and stability of a Nissan Versa (Almera) passenger sedan car by introducing novel modifications. These modifications included single inverted wings with end plates as a front spoiler, double‐element inverted wings with end plates as a rear spoiler, and incorporating the ground as a diffuser under the car trunk. The goal is to enhance the performance and stability of conventional passenger cars. To ensure the accuracy of the numerical data, the study utilized multiple methodologies to model the turbulence model, ultimately selecting the most suitable option. This involved comparing numerical data with wind tunnel experimental data using force balance and pressure distribution. Once validated, the computational fluid dynamics (CFD) was employed to analyze the vehicle's aerodynamic performance relative to the straight‐line condition under cornering conditions. The car simulation in a cornering condition was conducted at a representative Reynolds number based on the vehicle length of about 1.3 × 107. The study discovered that asymmetry was a recurring theme regarding surface pressure distribution, with greater prominence under cornering conditions. All modified models exhibited a more favorable lift‐to‐drag ratio than the baseline, indicating improved aerodynamic efficiency. The underbody double‐element diffuser proved most effective for enhancing fuel efficiency and stability. Mesh refinement with a polyhedral algorithm consisting of 11.27 million elements and a computational domain with a frontal area of 91.8 m2 and a curved length of 31 m (˜7 times car length) was crucial for achieving accurate and repeatable results. The study employed multiple turbulence models within the CFD framework. The realizable k‐ε model was chosen due to its balance between accuracy and computational cost for all Nissan Versa models. These findings are limited to the selected parameters and wind tunnel conditions, and further investigations might be needed for extreme driving scenarios.