bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple Organic Salts Having a Naphthalenediimide (NDI) Core Display Multifunctional Properties: Gelation, Anticancer and Semiconducting Properties
Authors: Parveen Rumana , Maity Nabasmita , Dastidar Parthasarathi 
Published: November 2017

AbstractFollowing a supramolecular synthon rationale, a dicarboxylic acid derivative having a naphthalenediimide (NDI) core, namely, bis‐N‐carboxymethyl naphthalenediimide (NDI‐G), was reacted with n‐alkyl amines with varying alkyl chain lengths to generate a new series of primary ammonium dicarboxylate (PAD) salts. The majority of the salts (≈85 %) were found to gel various polar solvents. The gels were characterized by dynamic rheology and high‐resolution electron microscopy. Single‐crystal and powder X‐ray diffraction analyses were used to study the supramolecular synthon present in one of the gelator salts (i.e., S8). Charge‐transfer (CT)‐induced gelation with donor molecules such as anthracene methanol (Ant) and pyrene (Py) was also possible with S8. The CT complex (S8.Ant) displayed anticancer activity as probed by cell migration assay on the highly aggresive breast cancer cell line MDA‐MB‐231. The DMSO gel of S8.Ant also displayed semiconducting behavior. To the best of our knowledge, simple organic salts with an NDI core that display such mulitifunctional properties are hitherto unknown.
Resveratrol, pterostilbene, and dementia
Authors: Lange Klaus W. , Li Shiming 
Published: November 2017

AbstractResveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro antioxidant, anti‐inflammatory, and antiamyloid effects. Resveratrol and its derivative pterostilbene are able to cross the blood‐brain barrier and to influence brain activity. The present short review summarizes the available evidence regarding the effects of these polyphenols on pathology and cognition in animal models and human subjects with dementia. Numerous investigations in cellular and mammalian models have associated resveratrol and pterostilbene with protection against dementia syndromes such as Alzheimer's disease (AD) and vascular dementia. The neuroprotective activity of resveratrol and pterostilbene demonstrated in in vitro and in vivo studies suggests a promising role for these compounds in the prevention and treatment of dementia. In comparison to resveratrol, pterostilbene appears to be more effective in combatting brain changes associated with aging. This may be attributed to the more lipophilic nature of pterostilbene with its two methoxyl groups compared with the two hydroxyl groups of resveratrol. The findings of available intervention trials of resveratrol in individuals with mild cognitive impairment or AD do not provide evidence of neuroprotective or therapeutic effects. Future clinical trials should be conducted with long‐term exposure to preparations of resveratrol and pterostilbene with high bioavailability. © 2017 BioFactors, 44(1):83–90, 2018
Probing the activity of a recombinant Zn2+‐transporting P‐type ATPase
Authors: Ravishankar H. , Barth A. , Andersson M. 
Published: November 2017

AbstractP‐type ATPase proteins maintain cellular homeostasis and uphold critical concentration gradients by ATP‐driven ion transport across biological membranes. Characterization of single‐cycle dynamics by time‐resolved X‐ray scattering techniques in solution could resolve structural intermediates not amendable to for example crystallization or cryo‐electron microscopy sample preparation. To pave way for such time‐resolved experiments, we used biochemical activity measurements, Attenuated Total Reflectance (ATR) and time‐dependent Fourier‐Transform Infra‐Red (FTIR) spectroscopy to identify optimal conditions for activating a Zn2+‐transporting Type‐I ATPase from Shigella sonnei (ssZntA) at high protein concentration using caged ATP. The highest total activity was observed at a protein concentration of 25 mg/mL, at 310 K, pH 7, and required the presence of 20% (v/v) glycerol as stabilizing agent. Neither the presence of caged ATP nor increasing lipid‐to‐protein ratio affected the hydrolysis activity significantly. This work also paves way for characterization of recombinant metal‐transporting (Type‐I) ATPase mutants with medical relevance.
Patient satisfaction with information on oral anticancer agent use
Authors: Boons Christel C. L. M. , Timmers Lonneke , van Schoor Natasja M. , Swart Eleonora L. , Hendrikse N. Harry , Janssen Jeroen J. W. M. , Hugtenburg Jacqueline G. 
Published: November 2017

AbstractAdequate information on oral anticancer agent (OACA) use is an essential element of optimal cancer care. The present study aimed to get insight into the experiences of patients with information on OACA treatment and their characteristics regarding information dissatisfaction. Patients of four Dutch university hospitals using OACA participated in this observational study and completed the Satisfaction with Information about Medicines Scale (SIMS), EORTC Quality of Life Questionnaire‐C30, Brief Illness Perception Questionnaire, and Beliefs about Medicines Questionnaire‐Specific. Logistic regression analyses were used to determine factors associated with dissatisfaction with information. Patients (n = 208) using capecitabine (35%), lenalidomide (15%), imatinib (14%), temozolomide (12%), sunitinib (11%), thalidomide (5%), dasatinib (4%), erlotinib (2%), and nilotinib (2%) participated. Information on the following SIMS‐items was inadequate: how OACA elicit their effect, how long it takes before treatment works, how to conclude that treatment is effective, the risk of side effects and its management, interference with sex life, drowsiness, interference with other medication and alcohol and what to do in case of a missed dose. Younger age, hematological malignancy, dyspnoea, positive perception of consequences of the cancer, low perception of treatment control, and indifferent attitude towards OACA were associated with dissatisfaction with information. In conclusion, a considerable number of patients would have appreciated receiving more information on specific issues relating to the consequences of OACA treatment such as the effects and side effects of OACA and the interference of treatment with various aspects of their daily life. Oncologists, hematologists, lung‐oncologists and pharmacists may reconsider the provision of information on OACA treatment.
Prognostic value of PD‐L1 expression in combination with CD8+TILs density in patients with surgically resected non‐small cell lung cancer
Authors: Yang Hui , Shi Jinpeng , Lin Dongmei , Li Xuefei , Zhao Chao , Wang Qi , Zhang Limin , Jiang Tao , Zhao Sha , Liu Xiaozhen , Jia Yijun , Zhang Yajun , Cai Weijing , Zhou Caicun 
Published: November 2017

AbstractTo investigate the prognostic value of PD‐L1 expression combined with CD8+ TILs density in patients with resected NSCLC and correlations with clinicopathological features. We retrospectively enrolled 178 patients with resected NSCLC from 2011 to 2015. All surgical primary and 58 matched metastatic lymph node specimens were tested for PD‐L1, CD8+ TILs, and oncogenic alterations. PD‐L1+ was detected in 71 (39.9%) and CD8high TILs in 74 (41.6%) cases. Smoking, SqCC, and EGFR− were associated with both PD‐L1+ and CD8high TILs. Patients with CD8high TILs had longer OS (P = 0.012). PD‐L1− was significantly associated with longer OS in patients with oncogenic alterations (P = 0.047). By multivariate analysis, CD8high TILs (HR = 0.411; 95% CI, 0.177–0.954; P = 0.038), rather than PD‐L1, was the independent predictive factor for OS. The longest and shortest OS were achieved in patients with PD‐L1+/CD8high and PD‐L1+/CD8low, respectively (P = 0.025). Inconsistent PD‐L1 expression levels were observed in 23 of 58 (39.7%) patients with primary and matched metastatic lymph node specimens. Of them, CD8high TILs was significantly associated with longer OS in patients with metastatic lymph nodes and/or consistent PD‐L1 expression (P = 0.017 and 0.049, respectively). The combination of PD‐L1 and CD8+ TILs density, instead of PD‐L1 alone, suggested impressive prognostic values in NSCLC patients. Less than half of patients with resected NSCLC experienced inconsistent PD‐L1 expression between primary and metastatic lesions. The level of PD‐L1 expression in advanced NSCLC needs to be evaluated more comprehensively.
Cancer‐testis gene PIWIL1 promotes cell proliferation, migration, and invasion in lung adenocarcinoma
Authors: Xie Kaipeng , Zhang Kai , Kong Jing , Wang Cheng , Gu Yayun , Liang Cheng , Jiang Tingting , Qin Na , Liu Jibin , Guo Xuejiang , Huo Ran , Liu Mingxi , Ma Hongxia , Dai Juncheng , Hu Zhibin 
Published: November 2017

AbstractPiwi‐like RNA‐mediated gene silencing 1 (PIWIL1) has been identified as a novel extremely highly expressed cancer‐testis (CT) gene in lung adenocarcinoma. However, the exact function and mechanism of PIWIL1 in lung adenocarcinoma remains unclear. Herein, we sought to investigate the role of PIWIL1 in the occurrence and development of lung adenocarcinoma. We examined the expression pattern of PIWIL1 in The Cancer Genome Atlas (TCGA) lung adenocarcinoma samples, and validated it by Real‐Time PCR (RT‐PCR) in additional 21 paired lung adenocarcinoma tissues and 16 normal tissues. Subsequently, we explored the biological function of PIWIL1 in A549 and H1299 cell lines by gain and loss‐of‐function analyses. Using TCGA lung adenocarcinoma data, we further performed coexpression and Gene Ontology (GO) analyses, and analyzed the association of DNA methylation levels in PIWIL1 promoter region with its expression. Finally, we evaluated its expression in different mutation status of significantly mutated genes (SMGs) in TCGA lung adenocarcinoma data. We observed that PIWIL1 was expressed in testis and lung adenocarcinoma but not in other normal tissues, and its high expression was associated with shortened survival of lung cancer patients. Overexpression of PIWIL1 could facilitate the proliferation, invasion and migration of lung adenocarcinoma cells and vice versa. GO analysis revealed that PIWIL1 upregulated genes were enriched in embryonic development, cell proliferation and regulation of transcription. Moreover, promoter DNA hypomethylation of PIWIL1 could contribute to its aberrant expression in tumors. Interestingly, PIWIL1 expression was significantly higher in patients without hepatocyte growth factor (HGF) or serine/threonine kinase 11 (STK11) mutation (P = 0.006 and 0.005, respectively). PIWIL1 is an epidriver gene in lung adenocarcinoma, indicating a potential target for further therapy.
A unique case of bilateral hydronephrosis caused by a fecalith
Authors: Kulkarni Archana , Kimoto Maryann , Morales Rafael , Kaura Amit 
Published: November 2017

Key Clinical MessageThis is a unique case that signifies the importance to look beyond the genitourinary system for causes of hydronephrosis. In addition, we outline the manner in which a fecalith should be addressed.
Successful elimination of premature ventricular contractions by ablation of origin and preferential pathway
Authors: Yazaki Kyoichiro , Enta Kenji , Watarai Masahiro , Kahata Mitsuru , Kumagai Asako , Inoue Koji , Koganei Hiroshi , Otsuka Masato , Ishii Yasuhiro 
Published: November 2017

Key Clinical MessageHowever, the common strategy for eliminating premature ventricular contractions (PVCs) is to explore the exit site and ablate, which may be difficult in some cases. The origin and the preferential pathway, an insulated pathway connected to the exit, may also become targets for eliminating PVCs.
Copper Oxide−Cobalt Nanostructures/Reduced Graphene Oxide/Biomass‐Derived Macroporous Carbon for Glucose Sensing
Authors: Wang Li , Xu Lijuan , Zhang Yayun , Yang Han , Miao Longfei , Peng Canwei , Song Yonghai 
Published: November 2017

AbstractA novel three‐dimensional kenaf‐stem‐derived macroporous carbon (3D‐KSC)/reduced graphene oxides (rGO) integrated electrode was constructed as a supporting matrix to deposit CuO−Co bimetallic nanostructures (CuO‐CoNSs) for electrochemical sensing of glucose. The rGO and CuO‐CoNSs were firmly grown on the channels of 3D‐KSC step‐by‐step to construct the CuO‐CoNSs/rGO/3D‐KSC integrated electrode. The obtained CuO‐CoNSs/rGO/3D‐KSC integrated electrode was carefully characterized with several techniques, such as SEM, Raman spectroscopy, FTIR, XRD, XPS, and electrochemistry. The results showed that lots of rGO covered the macropores of 3D‐KSC, which avoided the aggregation of rGO effectively and improved the utilization efficiency of 3D‐KSC. A large number of dendritic CuO‐CoNSs were subsequently grown in the macropores of the rGO/3D‐KSC integrated electrode. Owing to the hierarchical configuration, the CuO‐CoNSs/rGO/3D‐KSC integrated electrode showed superior performances for non‐enzymatic electrochemical glucose sensing with a suitable linear range (0.01–3.95 mM) and high sensitivity of 802.86 μA mM−1 cm−2. The result demonstrated that the electrode was suitable for detecting glucose in bodily fluids. The rGO/3D‐KSC might also be applied to load other NSs or enzymes for electrochemical sensing.
Organocatalyzed Decarboxylative Trichloromethylation of Morita–Baylis–Hillman Adducts in Batch and Continuous Flow
Authors: Enevoldsen Martin V. , Overgaard Jacob , Pedersen Maja S. , Lindhardt Anders T. 
Published: November 2017

AbstractTwo protocols for the organocatalyzed decarboxylative trichloromethylation of Morita–Baylis–Hillman (MBH) substrates have been developed. Applying sodium trichloroacetate, as the trichloromethyl anion precursor, in combination with an organocatalyst and acetylated MBH‐alcohols, the desired trichloromethylated products were obtained in good yields at room temperature in batch. The method was next extrapolated into a two‐step continuous flow protocol, starting directly from the MBH alcohols, in combination with tributylamine acting both as base and catalyst. The flow process proved superior to the batch approach, reducing the reaction time from 16 hours to only 20 minutes, with increased yields for all investigated entries. Two examples were also taken to scale‐up in flow producing more than 10 grams of both trichloromethylated targets. Finally, substitution of the organocatalyst to (DHQ)2PHAL or (DHQD)2PHAL induced chiral transfer to the generated stereocenter in the reaction attaining selectivities with nearly 90 % ee.
In Situ Generated Ruthenium–Arene Catalyst for Photoactivated Ring‐Opening Metathesis Polymerization through Photolatent N‐Heterocyclic Carbene Ligand
Authors: Pinaud Julien , Trinh Thi Kim Hoang , Sauvanier David , Placet Emeline , Songsee Sriprapai , Lacroix‐Desmazes Patrick , Becht Jean‐Michel , Tarablsi Bassam , Lalevée Jacques , Pichavant Loïc , Héroguez Valérie , Chemtob Abraham 
Published: November 2017

Abstract1,3‐Bis(mesityl)imidazolium tetraphenylborate (IMesH+ BPh4−) can be synthesized in one step by anion metathesis between the corresponding imidazolium chloride and sodium tetraphenylborate. In the presence of 2‐isopropylthioxanthone (sensitizer), an IMes N‐heterocyclic carbene (NHC) ligand can be photogenerated under irradiation at 365 nm through coupled electron/proton transfer reactions. By combining this tandem NHC photogenerator system with metathesis inactive [RuCl2(p‐cymene)]2 precatalyst, the highly active RuCl2(p‐cymene)(IMes) complex can be formed in situ, enabling a complete ring‐opening metathesis polymerization (ROMP) of norbornene in the matter of minutes at room temperature. To the best of our knowledge, this is the first example of a photogenerated NHC. Its exploitation in photoROMP has resulted in a simplified process compared to current photocatalysts, because only stable commercial or easily synthesized reagents are required.
Validation of X‐ray Wavefunction Refinement
Authors: Woińska Magdalena , Jayatilaka Dylan , Dittrich Birger , Flaig Ralf , Luger Peter , Woźniak Krzysztof , Dominiak Paulina M. , Grabowsky Simon 
Published: November 2017

AbstractIn this work, the quality of the electron density in crystals reconstructed by the multipolar model (MM) and by X‐ray wavefunction refinement (XWR) is tested on a set of high‐resolution X‐ray diffraction data sets of four amino acids and six tripeptides. It results in the first thorough validation of XWR. Agreement statistics, figures of merit, residual‐ and deformation‐density maps, as well as atomic displacement parameters are used to measure the quality of the reconstruction relative to the measured structure factors. Topological analysis of the reconstructed density is carried out to obtain atomic and bond‐topological properties, which are subsequently compared to the values derived from benchmarking periodic DFT geometry optimizations. XWR is simultaneously in better agreement than the MM with both benchmarking theory and the measured diffraction pattern. In particular, the obvious problems with the description of polar bonds in the MM are significantly reduced by using XWR. Similarly, modeling of electron density in the vicinity of hydrogen atoms with XWR is visibly improved.
What psychologists need to know about psychotropic medications
Authors: Tomba Elena , Guidi Jenny , Fava Giovanni A. 
Published: November 2017

Despite the fact that today most of the patients with psychological disturbances assume some form of psychotropic drug treatment, clinical psychologists may have little familiarity with psychopharmacology and are substantially unaware of subtle and yet pervasive potential effects of medications in clinical presentations. In their training, psychologists are generally exposed, at best, to some general principles of drug action. Standard psychopharmacology textbooks tend to omit the subtle psychological changes that may occur during psychotropic drug treatment.Clinical pharmacopsychology consists of the application of clinical psychology to the full understanding of pharmacological effects. The domains of clinical pharmacopsychology encompass the clinical benefits of psychotropic drugs, the characteristics that predict responsiveness to treatment, the vulnerabilities induced by treatment (side effects, behavioural toxicity, iatrogenic comorbidity), and the interactions between drug treatment and psychological variables.The DSM‐5 refers to a patient population that no longer exists: subjects who display various manifestations of psychological distress who do not receive any form of drug treatment for it.Any type of psychotropic drug treatment, particularly after long‐term use, may increase the risk of experiencing additional psychopathological problems that do not necessarily subside with discontinuation of the drug. The changes may be persistent and not limited to a short phase, such as in the case of withdrawal reactions, and cannot be subsumed under the generic rubrics of adverse events or side effects.
The relationship between perceived organisational threat and compassion for others: Implications for the NHS
Authors: Henshall Lauren Elizabeth , Alexander Tim , Molyneux Philip , Gardiner Eric , McLellan Ashleigh 
Published: November 2017

The National Health Service (NHS) is known to be a challenging place to work, with financial and performance targets placing increasing pressure on the organisation. This study aimed to investigate whether these pressures and threats might be detrimental to the quality of care and the compassion that the NHS strives to deliver. Quantitative data were collected via self‐report questionnaires from healthcare professionals across 3 NHS trusts in England in order to measure Self‐compassion; Compassion for Others; Perceived Organisational Threat; and Perceived Organisational Compassion. Qualitative data were also collected to explore the threats considered most pertinent to healthcare professionals at present. The key findings suggest that an increase in Perceived Organisational Threat may reduce an individual's ability to give compassion to others; however, Self‐compassion and Perceived Organisational Compassion were better predictors of Compassion for Others. This highlights the need to consider compassion at a systemic level, providing interventions and training not only to cultivate self‐compassion in healthcare professionals, but also to encourage compassion across the NHS more generally. In promoting self‐compassion and increasing the level of compassion that employees feel they receive at work, healthcare professionals may be better able to maintain or improve their level of compassion for service users and colleagues.
CXCR2 is critical for bacterial control and development of joint damage and pain in Staphylococcus aureus‐induced septic arthritis in mouse
Authors: Boff Daiane , Oliveira Vivian L. S. , Queiroz Junior Celso M. , Silva Tarcília A. , Allegretti Marcelo , Verri Waldiceu A. , Proost Paul , Teixeira Mauro M. , Amaral Flavio A. 
Published: November 2017

AbstractStaphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrophils have an important function in controlling bacterial burden. This work aimed to study the role of CXCR2 in the control of infection, hypernociception and tissue damage in S. aureus‐induced septic arthritis in mice. The kinetics of neutrophil recruitment correlated with the bacterial load recovered from inflamed joint after intra‐articular injection of S. aureus. Treatment of mice from the start of infection with the non‐competitive antagonist of CXCR1/2, DF2156A, reduced neutrophil accumulation, cytokine production in the tissue, joint hypernociception and articular damage. However, early DF2156A treatment increased the bacterial load locally. CXCR2 was important for neutrophil activation and clearance of bacteria in vitro and in vivo. Start of treatment with DF2156A 3 days after infection prevented increase in bacterial load and reduced the hypernociception in the following days, but did not improve tissue damage. In conclusion, treatment with DF2156A seems be effective in controlling tissue inflammation and dysfunction but its effects are highly dependent on the timing of the treatment start.
Phytochemical profiling of anti‐inflammatory Lavandula extracts via RP–HPLC–DAD–QTOF–MS and –MS/MS: Assessment of their qualitative and quantitative differences
Authors: Contreras María del Mar , Algieri Francesca , Rodriguez‐Nogales Alba , Gálvez Julio , Segura‐Carretero Antonio 
Published: November 2017

AbstractAs for other aromatic plants, there are many analytical methods for the determination of volatile compounds in lavender essential oils. Alternatively, in this study RP–HPLC–DAD–QTOF–MS was used for the profiling of the phytochemical constituents of hydromethanolic extracts of L. stoechas and L. dentata, which were obtained by pressurized liquid extraction. The spectrometric data revealed complex profiles constituted of a wide range of polar and semi‐polar phytochemicals, mainly, phenolic compounds (68). Most phenolic compounds (55) have not been previously reported in Lavandula; such is the case of caffeic acid‐based oligomers. Moreover, the analytical method was validated for the determination of phenolic compounds. Our findings showed both qualitative and quantitative differences between the extracts. In this sense, while hydroxycinnamic acids made up the largest class in both extracts, flavones were the most abundant class, accounting for 10.44 g (L. dentata) and 4.85 g (L. stoechas) per 100 g of dry extract. In conclusion, this analytical method provided essential information about the phytochemical composition of the studied medicinal plants, revealing novel constituents that were probably hidden for others. In addition, these results may help to understand the anti‐inflammatory properties of these extracts.