bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Composite Assemblies of Microparticles and Nanofibers for Tailored Wettability and Controlled Drug Delivery
Authors: Lavielle Nicolas , Hébraud Anne , Thöny‐Meyer Linda , Rossi René M. , Schlatter Guy 
Published: February 2017

The control of the drug release kinetics is of prime importance for the design of bioactive nanofibrous membrane. Whereas simple drug‐loaded electrospun poly(lactic acid) (PLA) nanofibrous membranes have a hydrophobic behavior with a water contact angle above 130°, the introduction of poly(ethylene glycol) (PEG) microparticles in the PLA mesh renders the resulting PLA–PEG composites hydrophilic with a water contact angle below 25° enabling water to penetrate efficiently into the mesh. Tuning the wettability impacts the drug release profile and is exploited to design multilayer membranes for temporal and spatial controlled drug delivery: amphiphilic bilayer nanofibrous membranes having one hydrophobic side of dye‐loaded PLA nanofibers and one hydrophilic layer of dye‐loaded PLA–PEG composite allow a preferential release from the hydrophilic side for more than 100 h. Sandwich‐like nanofibrous membranes with dye‐loaded PLA nanoparticles confined between two PLA nanofibrous layers are also envisaged for tailored temporal drug delivery. The delivery of the drug is thus controlled by the thickness and wettability of the external layers of the sandwich.
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Iron accumulation and dysregulation in the putamen in fragile X‐associated tremor/ataxia syndrome
Authors: Ariza Jeanelle , Rogers Hailee , Hartvigsen Anna , Snell Melissa , Dill Michael , Judd Derek , Hagerman Paul , Martínez‐Cerdeño Verónica 
Published: February 2017

AbstractBackground: Fragile X‐associated tremor/ataxia syndrome is an adult‐onset disorder associated with premutation alleles of the FMR1 gene. This disorder is characterized by progressive action tremor, gait ataxia, and cognitive decline. Fragile X‐associated tremor/ataxia syndrome pathology includes dystrophic white matter and intranuclear inclusions in neurons and astrocytes. We previously demonstrated that the transport of iron into the brain is altered in fragile X‐associated tremor/ataxia syndrome; therefore, we also expect an alteration of iron metabolism in brain areas related to motor control. Iron is essential for cell metabolism, but uncomplexed iron leads to oxidative stress and contributes to the development of neurodegenerative diseases. We investigated a potential iron modification in the putamen ‐ a structure that participates in motor learning and performance ‐ in fragile X‐associated tremor/ataxia syndrome.Methods: We used samples of putamen obtained from 9 fragile X‐associated tremor/ataxia syndrome and 9 control cases to study iron localization using Perl's method, and iron‐binding proteins using immunostaining.Results: We found increased iron deposition in neuronal and glial cells in the putamen in fragile X‐associated tremor/ataxia syndrome. We also found a generalized decrease in the amount of the iron‐binding proteins transferrin and ceruloplasmin, and decreased number of neurons and glial cells that contained ceruloplasmin. However, we found increased levels of iron, transferrin, and ceruloplasmin in microglial cells, indicating an attempt by the immune system to remove the excess iron.Conclusions: Overall, found a deficit in proteins that eliminate extra iron from the cells with a concomitant increase in the deposit of cellular iron in the putamen in Fragile X‐associated tremor/ataxia syndrome. © 2017 International Parkinson and Movement Disorder Society
Emergency department and inpatient coding for self‐harm and suicide attempts: Validation using clinician assessment data
Authors: Randall Jason R. , Roos Leslie L. , Lix Lisa M. , Katz Laurence Y. , Bolton James M. 
Published: February 2017

AbstractAdministrative data have been used to determine the occurrence of suicide attempts and deliberate self‐harm, but research about the accuracy of these sources is limited. This study used a clinical sample (n = 5719) containing psychiatry consultations from the emergency departments and inpatient units of the two major tertiary hospitals in Winnipeg, Canada to validate the accuracy of inpatient hospital diagnosis codes at identifying presentations for self‐harm and suicide attempts. The Columbia Classification Algorithm of Suicide Assessment (C‐CASA) was used as the gold standard. International Classification of Diseases version 10 Canadian Enhancement codes for intentional self‐harm, undetermined intent self‐harm, and accidental poisoning were assessed. Measures of validity included Kappa (κ), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Sensitivity of hospitalized attempts was low using intentional intent codes (36.9%, 95% confidence interval [CI]: 32.4–41.4%) but improved using unknown intent and accidental poisoning codes (44.8%, 95% CI: 40.2–49.4%). Agreement for suicide attempts did not increase with the addition of unknown intent and accidental poisoning codes (κ = 0.465–0.481), but were better for any self‐harm (κ = 0.395–0.478). Hospital diagnosis codes undercount attempts and self‐harm admissions. Including more data sources might improve the detection of events.
Pediatric nonrhabdomyosarcoma soft tissue sarcomas arising at visceral sites
Authors: Ferrari Andrea , Magni Chiara , Bergamaschi Luca , Cecchetto Giovanni , Alaggio Rita , Milano Giuseppe Maria , Bertolini Patrizia , Basso Eleonora , Manzitti Carla , Di Martino Martina , Giurici Nauga , Melchionda Fraia , Cecinati Valerio , Chiaravalli Stefano , Affinita Maria Carmen , Scagnellato Angela , Casanova Michela , Bisogno Gianni 
Published: February 2017

AbstractBackgroundPediatric nonrhabdomyosarcoma soft tissue sarcomas (NRSTS) may rarely occur in visceral tissues, and little is known about their clinical history. The present study retrospectively analyzed a group of patients prospectively registered in Italian pediatric protocols conducted between 1979 and 2004.MethodsInclusion criteria for the study were as follows: a pathological diagnosis of “adult‐type NRSTS,” arising at visceral sites (lung‐pleurae, liver, kidney, and mesentery‐bowel); age under 18 years; no previous treatment except for primary surgery; available clinical data; and written consent.ResultsThirty cases with visceral NRSTS were collected and analyzed. Sites of origin were as follows: mesentery‐bowel in 12 cases, lung‐pleurae in 11, liver in 5, and kidney in 2. According to the Intergroup Rhabdomyosarcoma Study (IRS) surgical grouping system, patients were classified as follows: nine IRS group I, three group II, 12 group III, and six group IV. Patients were treated with a multimodal approach including surgery, radiotherapy, and/or chemotherapy, according to their characteristics. For the series as a whole, the 5‐year event‐free and overall survival rates were 33.3% and 40.0%, respectively. The IRS group (reflecting the feasibility of initial complete resection) emerged as the main prognostic factor. Survival rates also correlated with tumor size and local invasiveness, histological subtype, and tumor sites (the worst outcome was seen for tumors arising in the lung and pleurae).ConclusionsThis study confirmed that visceral NRSTS are aggressive tumors carrying a worse prognosis than pediatric NRSTS arising in soft tissues of the extremities. Local treatment remains the main challenge for these tumors.
Scientific Importance of Water‐Processable PEDOT–PSS and Preparation, Challenge and New Application in Sensors of Its Film Electrode: A Review
Authors: Wen Yangping , Xu Jingkun 
Published: February 2017

ABSTRACTIn this review, PEDOT–PSS is mainly a commercially available PEDOT–PSS, which is a water‐dispersible form of the intrinsically conducting PEDOT doped with the water‐soluble PSS, including its derivatives, copolymers, analogs (PEDOT:PSSs), even their composites via the chemical or physical modification toward the structure of PEDOT and/or PSS. First, we will focus on discussing the scientific importance of PEDOT–PSS in conjunction with its extraordinary properties and broad multidisciplinary applications in organic/polymeric electronics and optoelectronics from the viewpoint of the historical development and the promising application of representative ECPs. Subsequently, versatile film‐forming techniques for the preparation of PEDOT–PSS film electrode were described in details, including common coating approaches and printing techniques, and many emerging preparative methods were mentioned. Then challenges (e.g., conductivity, stability in Water, adhesion to substrate electrode) of PEDOT–PSS film electrode for devices under the high humidity/watery circumstances, especially electrochemical devices are discussed. Fourth, we take PEDOT–PSS film electrode for a relatively new application in sensors as an example, mainly summarized advances in the development of various sensors based on PEDOT–PSSs and their composites in combination with its preparative methods and extraordinary properties. Finally, we give the outlook of PEDOT–PSS for possible applications with the emphasis on PEDOT–PSS film electrode for electrochemical devices, including sensors. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 55, 1121–1150
Glycidyl Azide‐Butadiene Block Copolymers: Synthesis from the Homopolymers and a Chain Extender
Authors: Filippi Sara , Mori Leonardo , Cappello Miriam , Polacco Giovanni 
Published: February 2017

AbstractGlycidyl azide polymer (GAP) is an “energetic” alternative to hydroxyl‐terminated polybutadiene (HTPB), but has poorer mechanical properties. Since HTPB‐GAP mechanical blends are markedly biphasic, the use of block copolymers may be the solution to join the advantages of both. The copolymers were synthesized from the homopolymers by using two chain extenders: hexamethylene diisocyanate (HDI) and adipoyl chloride (AdCl). Both reagents gave homogeneous and stable polymeric mixtures, but with HDI there are risks of gelation during reaction. Therefore, the product obtained with AdCl is the best candidate to be used as binder or as compatibilizer in GAP‐HTPB mechanical blends.
Integrated Approaches to Water Resource and Solid Waste Management for Sustainable Development
Authors: Ikhlayel Mahdi , Nguyen Lan Huong 
Published: February 2017

AbstractWe aim in this paper to address the sustainability challenge of how an integrated approach can lead to figuring out solutions to complex issues for modern societies. We reviewed papers related to integrated water resource management (IWRM) and integrated solid waste management (ISWM) to advocate some innovative concepts and methodologies of sustainability science. An investigation of the concepts of IWRM and ISWM over various sustainability science research clusters and dimensions is presented. Water resource management projects at different scales and across various geographical boundaries are reviewed to understand the IWRM approach. The ISWM approach is discussed with regard to research topics and methodologies from selected case studies in developed and developing countries. We sought to look at various definitions, the integrated elements, and the similarities and differences between the two approaches. We also present our definitions for each approach. Our findings show how integrated thinking can help in achieving sustainable development. Finally, we present our recommendations for possible implications to the integrated approach in order to accelerate the process of sustainable development. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Synthesis, Structural and Biological Studies of Some Half‐Sandwich d6‐Metal Complexes with Pyrimidine‐Based Ligands
Authors: Aradhyula Basava Punna Rao , Kalidasan Mahesh , Gangele Krishnakant , Deb Debojit K. , Shepherd Samanta L. , Phillips Roger M. , Poluri Krishna Mohan , Kollipara Mohan Rao 
Published: February 2017

AbstractThe reaction of metal precursors {[Cp*MCl2]2 (M=Rh, Ir)} with 2‐aminopyrimidine (L1) gave binuclear complexes as [(Cp*MCl2)2(μ‐L1)], where L1 acted as a bridging ligand. While 2‐mercaptopyrimidine (L2) with [Cp*MCl2]2 {M=Rh(III), Ir(III)} formed mononuclear di substituted complexes as [Cp*M(L2)2], where L2 acted as a chelating as well as a monodentate ligand. The reaction of [CpRu(PPh3)2Cl] with 2‐mercaptopyrimidine (L2) led to the formation of mononuclear complex as general formula [CpRu(PPh3)(L2)] in presence of a base. 2‐Mercaptopyrimidine ligand resulted complexes with strained four‐membered metallacycle while 2‐aminopyrimidine yielded bridged complexes. HOMO‐LUMO energy gaps and UV‐Visible bands were additionally rationalised by the DFT studies. The binding ability of the complexes to the CT‐DNA was confirmed using UV‐Visible and fluorescence spectroscopy. In vitro antibacterial activity of the complexes was evaluated against human pathogenic bacteria. Cytotoxicity of the complexes was examined by the MTT assay over three cancerous and one non‐cancer cell lines viz., BE, HT‐29, MIA−Pa‐Ca2 and ARPE‐19.
1,4‐Disubstituted 1,2,3‐Triazole‐ and 1,5‐Disubstituted 1,2,3‐Triazole–based Bis‐Sulfonamides in Selective Fluorescence Sensing of ATP
Authors: Dey Santu , Sarkar Tanmay , Majumdar Anupam , Pathak Tanmaya , Ghosh Kumaresh 
Published: February 2017

Abstract1,4‐ and 1,5‐Disubstituted 1,2,3‐triazole scaffolds as surrogate of amide with large dipole moment have been utilized to access two isomeric naphthylthiourea‐based chemosensors 1 and 2 in appreciable overall yields. The easily synthesizable chemosensors 1 and 2 are designed to recognize anions and also to realize a comparative view on their sensing potentials. Different inorganic phosphates and a group of phosphorylated nucleosides such as ATP, ADP and AMP are selectively recognized by these chemosensors in semi aqueous system. The fluorometric study revealed that both the sensors sensed ATP selectively in CH3CN/H2O (4/1,v/v) by showing considerable increase in emission. 1,4‐Disubstituted triazole‐based sensor 1 has been established to be more effective than the 1,5‐disubstituted triazole‐based sensor 2 in selective sensing of ATP.
Introducing Supramolecular Interactions into Robust Bis(tetrabromocatecholate) Chelated Manganese(III) Systems and Biomimetic Catalytic Activity
Authors: Panja Anangamohan , Jana Narayan Ch. , Bauzá Antonio , Adak Sarmistha , Mwania Tom M. , Eichhorn David M. , Frontera Antonio 
Published: February 2017

AbstractThis report deals with the syntheses, structures, supramolecular interactions, and biomimetic catalytic activity of three new manganese(III) complexes (1–3) containing the tetrabromocatechol ligand. Three different amines were used, with the goal of introducing their protonated species into the crystal lattice as counter cations for the robust bis(tetrabromocatecholate) chelated manganese(III) anionic species. All these systems present interesting noncovalent interactions in their crystal packing, including hydrogen bonding, halogen bonding, π –stacking and anion–π interactions. The geometrical differences (octahedral vs square pyramidal) have been analyzed by means of DFT studies, revealing that the strong anion–π interaction of pyridine with the complex anion compensates for the absence of one apical methanol molecule in 3. All of the complexes exhibited leveling catalytic activity for aerobic oxidation of 3,5‐di‐tert‐butylcatechol. DFT calculations support the formation of a stable complex‐substrate intermediate through hydrogen bonding, thereby disclosing the origin of catecholase activity of these complex anions.
Uncovering sustainability concerns in software product lines
Authors: Chitchyan Ruzanna , Groher Iris , Noppen Joost 
Published: February 2017

AbstractSustainable living, ie, living within the bounds of the available environmental, social, and economic resources, is the focus of many present‐day social and scientific discussions. But what does sustainability mean within the context of software engineering? In this paper, we undertake a comprehensive analysis of 8 case studies to address this question within the context of a specific software engineering approach, software product line engineering (SPLE). We identify the sustainability‐related characteristics that arise in present‐day studies that apply SPLE. We conclude that technical and economic sustainability are in prime focus on the present SPLE practice, with social sustainability issues, where they relate to organisations, also addressed to a good degree. On the other hand, the issues related to the personal sustainability are less prominent, and environmental considerations are nearly completely amiss. We present feature models and cross‐relations that result from our analysis as a starting point for sustainability engineering through SPLE, suggesting that any new development should consider how these models would be instantiated and expanded for the intended sociotechnical system. The good representation of sustainability features in these models is also validated with 2 additional case studies.
Oxidative stress and genetic damage among workers exposed primarily to organophosphate and pyrethroid pesticides
Authors: Zepeda‐Arce Rigoberto , Rojas‐García Aurora Elizabeth , Benitez‐Trinidad Alma , Herrera‐Moreno José Francisco , Medina‐Díaz Irma Martha , Barrón‐Vivanco Briscia S. , Villegas Germán Pier , Hernández‐Ochoa Isabel , Sólis Heredia María de Jesús , Bernal‐Hernández Yael Y. 
Published: February 2017

AbstractThe indiscriminate use of pesticides in agriculture and public health campaigns has been associated with an increase of oxidative stress and DNA damage, resulting in health outcomes. Some defense mechanisms against free radical‐induced oxidative damage include the antioxidant enzyme systems. The aim of this study was to determine the levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and the relationship of antioxidant enzyme levels with DNA damage among sprayers (workers) occupationally exposed to pesticides. The determinations of MDA and antioxidant enzymes were performed spectrophotometrically. The genotoxic effects were evaluated using the comet assay. The results showed a marginally significant decrease in SOD and CAT activities in the high exposure group compared to the control group. For MDA, statistically significant differences were found among people working long term vs. those working temporarily (P = 0.02) as sprayers. In the moderate exposure group, a positive correlation was observed between MDA levels and GPx activity. In the high exposure group, a negative correlation was observed between GR and CAT activities, and between MDA levels and GPx activities. Furthermore, in the high exposure group, a positive correlation between DNA damage parameters and MDA levels was observed. The results suggest an important role of antioxidant enzymes for the protection of DNA damage caused by occupational exposure to pesticides.
Use Cases and Suitability Metrics for Unit Ontologies
Authors: Steinberg Markus D. , Schindler Sirko , Keil Jan Martin 
Published: February 2017

AbstractUnits of measurement are an essential part of dataset descriptions as they are required for a valid interpretation of the data. One obvious choice for representing units are ontologies, but as every application supports different use cases a multitude of ontologies has been created. Each of these is suited best for just a subset of the possible use cases. The problem of choosing an ontology for a new project hence consists of two major aspects: What use cases need to be covered and which ontology caters best to them?We describe possible use cases and analyze their requirements. The results are then used to assess the modeling of the domain in different ontologies with respect to their suitability for those use cases. This analysis shows the differences in the support for different use cases. It can help developers to choose the best ontology for their specific needs and also highlights areas for further ontology improvement.
Selection of Two Identical Pictures from a Group of Similar Ones II: Changes in Ongoing EEG Activity
Authors: Petrek Josef 
Published: February 2017

Abstract
The paper presents finding of an experiment the aim of which was to judge the impact of an instant cognitive activity (identical pictures searching) on behavior of ongoing EEG activity. Two types of mental task were used: The first — passive watching of a blank white oval and the second — active searching for identical pictures in a group of similar nine line-drawings of living individuals or inanimate objects filling out the white oval.
Presented results showed that higher mental load pertinent to active searching for identical pictures in a group of similar pictures results in the prominent event-related desynchronization (ERD) — the mean Total Power value, a quantitative measure of ERD extent, in comparison with reference level (passive watching) was lower while solving the mental task.
The results also showed that the actual mental task performance affects the ERD only at some scalp-recording sites. The mean EEG Total Power significantly decreases at parietal and frontal scalp-recording sites whereas the significant decrease of the Frequency at Maximum Power involves occipital scalp electrodes, too.
Our results also demonstrated that some subject’s personality traits (moderation, openness and extraversion) affect the actual decrease/increase in size of Frequency at Maximum Power during active mental task solving.
Presented findings point at the high suitability of the ERD method to uncover differences in people’s brain activation patterns when engaged in performing cognitively demanding tasks.
Compulsive Hoarding in an Older Adult with Aggression, Delusions and Memory Loss: A Multimodality Neuroimaging Study
Authors: Chennamchetty Vijay N. , Poprawski Teresa J. , Crayton John W. , Hamilton Elizabeth A. , Konopka Lukasz M. 
Published: February 2017

Abstract
Multimodal assessment practices offer enriching contributions to linkages between clinical presentation and brain presen-tation. The following case study is an illustration of the effectiveness of structural and functional imaging in the diagnosis process. In this article a clinical vignette is given in which the client (Mr. B) presents with aggressive behavior, delu-sions, memory complaints and hoarding behaviors. The findings of the case of presented based on multimodal structural and functional imaging. Mr. B was evaluated using MRI (magnetic resonance imaging), EEG (electroencephalography), qEEG (quantitative EEG), LORETA (low resolution electromagnetic tomography), SPECT (single photon emission computed tomography), quantitative SPECT and neuropsychological testing.
Visual analysis of EEG recording revealed sharp waves with reversals primarily in the mid-central region (Cz). Quantita-tive analysis of background activity acquired in eyes closed and alert state revealed increased absolute and relative beta power maximally distributed to the mid-central region (Cz). This was consistent with the source analysis obtained from LORETA. Visual inspection of SPECT data indicated increased blood perfusion in the posterior cingulate cortex. The quantitative analysis of SPECT images, on the contrary revealed decreased perfusion in both anterior and posterior cingu-late cortex. Furthermore, increased perfusion in bilateral sensori-motor cortices (right more than left) and decreased per-fusion in the left posterior temporal lobe was observed. T-1 based MRI of the brain showed generalized cerebral atrophy. On neuropsychological testing Mr. B was able to complete only tests of lesser complexity. Base on published data Mr. B’s structural and functional imaging can be linked to his clinical presentation and a potential diagnosis of Frontal Tem-poral lobe Disorder (FTD). The use of multimodalities and objective analysis of data can lead to more accurate case con-ceptualizations and linkages between brain structure/functionality and clinical presentation.