bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis
Authors: Starke Robert M. , Thompson John W. , Ali Muhammad S. , Pascale Crissey L. , Martinez Lege Alejandra , Ding Dale , Chalouhi Nohra , Hasan David M. , Jabbour Pascal , Owens Gary K. , Toborek Michal , Hare Joshua M. , Dumont Aaron S. 
Published: January 2018

Objective—
Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on vascular smooth muscle cell (VSMC) phenotypic modulation and pathogenesis of CAs is unknown. The goal of this study was to investigate whether CSE activates a NOX (NADPH oxidase)-dependent pathway leading to VSMC phenotypic modulation and CA formation and rupture.

Approach and Results—

In cultured cerebral VSMCs, CSE increased expression of NOX1 and reactive oxygen species which preceded upregulation of proinflammatory/matrix remodeling genes (MCP-1, MMPs [matrix metalloproteinase], TNF-α, IL-1β, NF-κB, KLF4 [Kruppel-like factor 4]) and downregulation of contractile genes (SM-α-actin [smooth muscle α actin], SM-22α [smooth muscle 22α], SM-MHC [smooth muscle myosin heavy chain]) and myocardin. Inhibition of reactive oxygen species production and knockdown of NOX1 with siRNA or antisense decreased CSE-induced upregulation of NOX1 and inflammatory genes and downregulation of VSMC contractile genes and myocardin. p47phox
−/−
NOX knockout mice, or pretreatment with the NOX inhibitor, apocynin, significantly decreased CA formation and rupture compared with controls. NOX1 protein and mRNA expression were similar in p47phox
−/−
mice and those pretreated with apocynin but were elevated in unruptured and ruptured CAs. CSE increased CA formation and rupture, which was diminished with apocynin pretreatment. Similarly, NOX1 protein and mRNA and reactive oxygen species were elevated by CSE, and in unruptured and ruptured CAs.

Conclusions—
CSE initiates oxidative stress-induced phenotypic modulation of VSMCs and CA formation and rupture. These molecular changes implicate oxidative stress in the pathogenesis of CAs and may provide a potential target for future therapeutic strategies.
Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration
Authors: Natarajan Niranjana , Abbas Yamen , Bryant Donald M. , Gonzalez-Rosa Juan Manuel , Sharpe Michka , Uygur Aysu , Cocco-Delgado Lucas H. , Ho Nhi Ngoc , Gerard Norma P. , Gerard Craig J. , MacRae Calum A. , Burns Caroline E. , Burns C. Geoffrey , Whited Jessica L. , Lee Richard T. 
Published: January 2018

Background:
Defining conserved molecular pathways in animal models of successful cardiac regeneration could yield insight into why adult mammals have inadequate cardiac regeneration after injury. Insight into the transcriptomic landscape of early cardiac regeneration from model organisms will shed light on evolutionarily conserved pathways in successful cardiac regeneration.

Methods:
Here we describe a cross-species transcriptomic screen in 3 model organisms for cardiac regeneration: axolotl, neonatal mice, and zebrafish. Apical resection to remove ≈10% to 20% of ventricular mass was carried out in these model organisms. RNA-sequencing analysis was performed on the hearts harvested at 3 time points: 12, 24, and 48 hours after resection. Sham surgery was used as internal control.

Results:
Genes associated with inflammatory processes were found to be upregulated in a conserved manner. Complement receptors (activated by complement components, part of the innate immune system) were found to be highly upregulated in all 3 species. This approach revealed induction of gene expression for complement 5a receptor 1 in the regenerating hearts of zebrafish, axolotls, and mice. Inhibition of complement 5a receptor 1 significantly attenuated the cardiomyocyte proliferative response to heart injury in all 3 species. Furthermore, after left ventricular apical resection, the cardiomyocyte proliferative response was diminished in mice with genetic deletion of complement 5a receptor 1.

Conclusions:
These data reveal that activation of complement 5a receptor 1 mediates an evolutionarily conserved response that promotes cardiomyocyte proliferation after cardiac injury and identify complement pathway activation as a common pathway of successful heart regeneration.
Imaging the Spatiotemporal Dynamics of Cognitive Processes at High Temporal Resolution
Authors: Tal I. , Abeles M. 
Published: January 2018

This letter presents a noninvasive imaging technique that captures the exact timing and locations of cortical activity sequences that are specific to a cognitive process. These precise spatiotemporal sequences can be detected in the human brain as specific time-position pattern associated with a cognitive task. They are consistent with direct measurements of population activity recorded in nonhuman primates, thus suggesting that specific time-position patterns associated with a cognitive task can be identified. This imaging technique is based on estimating the amplitude of cortical current dipoles from MEG recordings. Although the spatial resolution of these estimations is poor (approximately 2 cm), the temporal resolution is high (milliseconds). We show that within these cortical current dipoles, time points of cortical activation can be identified as brief amplitude undulations and that sequences of these transients repeat with millisecond accuracy, hence making it possible to treat the timing of these transients as point processes. We illustrate the feasibility of finding spatiotemporal templates specific to the cognitive processes associated with following the rhythm of drumbeats that involve the activation at multiple cortical and cerebellar loci. These templates evolve at an accuracy of a few milliseconds. This approach can thus pave the way for new perspectives on the relationships between brain dynamics and cognition.
Accounting for Gravitational Attraction and Loading Effects from Land Ice on Absolute Sea Level
Authors: Ponte Rui M. , Quinn Katherine J. , Piecuch Christopher G. 
Published: January 2018

AbstractGravitational attraction and loading (GAL) effects associated with ongoing long-term changes in land ice are expected to cause spatially varying trends in absolute sea level ζ, as measured by satellite altimeters. The largest spatial gradients in ζ trends, predicted from solving the sea level equation using GRACE retrievals of mass distribution over land for the period 2005–15, occur near Greenland and West Antarctica, consistent with a strong local land ice loss. Misinterpreting the estimated static GAL trends in ζ as dynamic pressure gradients can lead to substantial errors in large-scale geostrophic transports across the Southern Ocean and the subpolar North Atlantic over the analyzed decade. South of Greenland, where altimeter sea level and hydrography (Argo) data coverage is good, the residual ζ minus steric height trends are similar in magnitude and sign to the gravitationally based predictions. In addition, estimated GAL-related trends are as large—if not larger than—other factors, such as deep steric height, dynamic bottom pressure, and glacial isostatic rebound. Thus, accounting for static GAL effects on ζ records, which are commonly neglected in oceanographic studies, seems important for a quantitative interpretation of the observed ζ trends.
Evaluating the Impact of Improvement in the Horizontal Diffusion Parameterization on Hurricane Prediction in the Operational Hurricane Weather Research and Forecast (HWRF) Model
Authors: Zhang Jun A. , Marks Frank D. , Sippel Jason A. , Rogers Robert F. , Zhang Xuejin , Gopalakrishnan Sundararaman G. , Zhang Zhan , Tallapragada Vijay 
Published: January 2018

Abstract
Improving physical parameterizations in forecast models is essential for hurricane prediction. This study documents the upgrade of horizontal diffusion parameterization in the Hurricane Weather Research and Forecasting (HWRF) Model and evaluates the impact of this upgrade on hurricane forecasts. The horizontal mixing length Lh was modified based on aircraft observations and extensive idealized and real-case numerical experiments. Following an earlier work by the first two authors, who focused on understanding how the horizontal diffusion parameterization worked in HWRF and its dynamical influence on hurricane intensification using idealized simulations, a series of sensitivity experiments was conducted to simulate Hurricane Earl (2010) in which only Lh was varied. Results from the Earl forecasts confirmed the findings from previous theoretical and idealized numerical studies, in that both the simulated maximum intensity and intensity change rate are dependent on Lh. Comparisons between the modeled and observed structure of Hurricane Earl, such as storm size, boundary layer heights, warm-core height and temperature anomaly, and eyewall slope, suggested that the Lh used in the HWRF Model should be decreased. Lowering Lh in HWRF has a positive impact on hurricane prediction based on over 200 retrospective forecasts of 10 Atlantic storms. Biases in both storm intensity and storm size are significantly reduced with the modified Lh.
As in Real Estate, Location Is What Matters: A Case Report of Transplant Ureteral Obstruction Due to an Inguinal Hernia
Authors: Bugeja Ann , Clark Edward G. , Sood Manish M. , Ali Sohrab N. 
Published: January 2018

Background: Kidney allograft dysfunction is common and often reversible but can lead to allograft loss if not promptly evaluated. Transplant ureteral obstruction in an inguinal hernia is a rare cause of allograft dysfunction, but early recognition may prevent allograft loss. Case Presentation: We present a case of a man with acute kidney allograft dysfunction who received a deceased donor kidney transplant 6 years earlier for end-stage kidney disease secondary to polycystic kidney disease. Abdominal ultrasounds revealed hydronephrosis without full visualization of the transplant ureter. Abdominal computed tomography revealed moderate hydronephrosis of the transplant kidney due to obstructed herniation of the transplant ureter in a right inguinal hernia. A stent was inserted into the transplant ureter to prevent further allograft dysfunction and facilitate hernia repair. Conclusions: Transplant ureteral obstruction is a rare cause of acute kidney allograft dysfunction, and its detection can be challenging. The recognition of transplant ureteral obstruction is vital to timely management for preventing allograft loss.
Intersection of Stress and Gender in Association With Transitions in Past Year DSM-5 Substance Use Disorder Diagnoses in the United States
Authors: Verplaetse Terril L. , Moore Kelly E. , Pittman Brian P. , Roberts Walter , Oberleitner Lindsay M. , Smith Philip H. , Cosgrove Kelly P. , McKee Sherry A. 
Published: January 2018

Background Stress contributes to the development and maintenance of substance use disorders, with some research suggesting that the impact of stress on substance use disorders is greater in women. However, this has yet to be evaluated in a national dataset, across major substances of abuse. Methods Using data from the newly available U.S. National Epidemiologic Survey on Alcohol and Related Conditions (NESARC; Wave 3; n = 36,309), we evaluated relationships among past year stressful life events (0 or 1 vs. 2+ events, range 0–16) and gender, and their association with transitions (new vs. absent cases; ongoing vs. remitted cases) in Diagnostic and Statistical Manual of Mental Disorders Fifth Edition alcohol use disorder, tobacco use disorder, cannabis use disorder, and nonmedical prescription opioid use disorder diagnoses. Results Having two or more stressful life events in the past year increased the odds of having a new alcohol use disorder, tobacco use disorder, cannabis use disorder, and opioid use disorder (OR = 3.14, 2.15, 5.52, and 3.06, respectively) or ongoing alcohol use disorder, tobacco use disorder, and cannabis use disorder (OR = 2.39, 2.62, and 2.95, respectively) compared to zero or one stressful life event. A stress by gender interaction for new vs. absent alcohol use disorder demonstrated that having two or more stressful life events was associated with increased odds of new alcohol use disorder in men (OR = 2.51) and even greater odds of new alcohol use disorder in women (OR = 3.94). Conclusions Results highlight that stress is a robust factor in both men and women with new or ongoing substance use disorders, and that effective treatments for substance use should consider the role of stress in addiction etiology and maintenance. There was little evidence for gender differences in the role of stress on transitions in substance use disorders, except for the onset of alcohol use disorders. Given that rates of alcohol use disorders are increasing in women, the impact of stress needs to be considered.
Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML
Authors: Swords Ronan T. , Coutre Steven , Maris Michael B. , Zeidner Joshua F. , Foran James M. , Cruz Jose , Erba Harry P. , Berdeja Jesus G. , Tam Wayne , Vardhanabhuti Saran , Pawlikowska-Dobler Iwona , Faessel Hélène M. , Dash Ajeeta B. , Sedarati Farhad , Dezube Bruce J. , Faller Douglas V. , Savona Michael R. 
Published: January 2018

Key Points
RP2D of PEV 20 mg/m2 in PEV/AZA combo did not alter toxicity profile of AZA; dose-limiting toxicities were transiently elevated AST/ALT. In treatment-naive older AML patients, the intent-to-treat ORR was 50%.
Does education raise productivity and wages equally? The moderating role of age and gender
Authors: Kampelmann Stephan , Rycx François , Saks Yves , Tojerow Ilan 
Published: January 2018

Abstract
We estimate the impact of education on productivity, wage costs and productivity-wage gaps (i.e. profits) using Belgian linked panel data. Findings highlight that educational credentials have a stronger impact on productivity than on wage costs. Firms’ profitability is found to rise when lower educated workers are substituted by higher educated ones. This effect is found to be more pronounced among younger workers and women. Findings thus suggest that the productivity to wage cost ratio of low-educated workers is detrimental to their employability, especially when young or female. They also support the existence of a glass ceiling on women’s career development.
A Visit to the Home of Lithium
Authors: King J. R. 
Published: January 2018

Late one October afternoon in 1984, I left the grey London drizzle behind and took off on a flight bound for Aarhus, major city on the east coast of Jutland, Denmark.Within twenty minutes the jet, appropriately called a Viking, had climbed above the turbulence of the clouds and was cruising through a serene dimension poised somewhere between the night sky, the sunset, and the purple rainclouds far below. Such a passage from turbulence into even stability is. I reflected, a familiar experience to the hundreds of thousands of people who have now benefited from tithium all over the world. But the introduction and acceptance of lithium therapy have been far from smooth, and would perhaps not have been possible at all were it not for the commitment and persistence of a few dedicated individuals.
The History of Mental Handicap in Bristol and Bath
Authors: Jancar J. 
Published: January 2018

The cities of Bristol and Bath have played an eminent role in the history of mental handicap.Unfortunately, documentation is rather scanty, particularly on the pre and post Reformation era but much more is known about the Holy Cross Hospital in Bath, perhaps the oldest mental handicap hospital in Great Britain. The Romans contributed to its foundations when they built Fossway Road on the outskirts of Bath which the pilgrims later used to visit Glastonbury.
Post-Treatment Mortality After Surgery and Stereotactic Body Radiotherapy for Early-Stage Non–Small-Cell Lung Cancer
Authors: Stokes William A. , Bronsert Michael R. , Meguid Robert A. , Blum Matthew G. , Jones Bernard L. , Koshy Matthew , Sher David J. , Louie Alexander V. , Palma David A. , Senan Suresh , Gaspar Laurie E. , Kavanagh Brian D. , Rusthoven Chad G. 
Published: January 2018

Purpose In early-stage non–small cell lung cancer (NSCLC), post-treatment mortality may influence the comparative effectiveness of surgery and stereotactic body radiotherapy (SBRT), with implications for shared decision making among high-risk surgical candidates. We analyzed early mortality after these interventions using the National Cancer Database. Patients and Methods We abstracted patients with cT1-T2a, N0, M0 NSCLC diagnosed between 2004 and 2013 undergoing either surgery or SBRT. Thirty-day and 90-day post-treatment mortality rates were calculated and compared using Cox regression and propensity score–matched analyses. Results We identified 76,623 patients who underwent surgery (78% lobectomy, 20% sublobar resection, 2% pneumonectomy) and 8,216 patients who received SBRT. In the unmatched cohort, mortality rates were moderately increased with surgery versus SBRT (30 days, 2.07% v 0.73% [absolute difference (Δ), 1.34%]; P < .001; 90 days, 3.59% v 2.93% [Δ, 0.66%]; P < .001). Among the 27,200 propensity score–matched patients, these differences increased (30 days, 2.41% v 0.79% [Δ, 1.62%]; P < .001; 90 days, 4.23% v 2.82% [Δ, 1.41%]; P < .001). Differences in mortality between surgery and SBRT increased with age, with interaction P < .001 at both 30 days and 90 days (71 to 75 years old: 30-day Δ, 1.87%; 90-day Δ, 2.02%; 76 to 80 years old: 30-day Δ, 2.80%; 90-day Δ, 2.59%; > 80 years old: 30-day Δ, 3.03%; 90-day Δ, 3.67%; all P ≤ .001). Compared with SBRT, surgical mortality rates were higher with increased extent of resection (30-day and 90-day multivariate hazard ratio for mortality: sublobar resection, 2.85 and 1.37; lobectomy, 3.65 and 1.60; pneumonectomy, 14.5 and 5.66; all P < 0.001). Conclusion Differences in 30- and 90-day post-treatment mortality between surgery and SBRT increased as a function of age, with the largest differences in favor of SBRT observed among patients older than 70 years. These representative mortality data may inform shared decision making among patients with early-stage NSCLC who are eligible for both interventions.
Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline
Authors: Kindler Hedy L. , Ismaila Nofisat , Armato Samuel G. , Bueno Raphael , Hesdorffer Mary , Jahan Thierry , Jones Clyde Michael , Miettinen Markku , Pass Harvey , Rimner Andreas , Rusch Valerie , Sterman Daniel , Thomas Anish , Hassan Raffit 
Published: January 2018

Purpose To provide evidence-based recommendations to practicing physicians and others on the management of malignant pleural mesothelioma. Methods ASCO convened an Expert Panel of medical oncology, thoracic surgery, radiation oncology, pulmonary, pathology, imaging, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 1990 through 2017. Outcomes of interest included survival, disease-free or recurrence-free survival, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. Results The literature search identified 222 relevant studies to inform the evidence base for this guideline. Recommendations Evidence-based recommendations were developed for diagnosis, staging, chemotherapy, surgical cytoreduction, radiation therapy, and multimodality therapy in patients with malignant pleural mesothelioma. Additional information is available at www.asco.org/thoracic-cancer-guidelines and www.asco.org/guidelineswiki .
Comparing the cost-per-QALYs gained and cost-per-DALYs averted literatures
Authors: Neumann Peter J. , Anderson Jordan E. , Panzer Ari D. , Pope Elle F. , D'Cruz Brittany N. , Kim David D. , Cohen Joshua T. 
Published: January 2018

Background: We examined the similarities and differences between studies using two common metrics used in cost-effectiveness analyses (CEAs): cost per quality-adjusted life years (QALYs) gained and cost per disability-adjusted life year (DALY) averted.Methods: We used the Tufts Medical Center CEA Registry, which contains English-language cost-per-QALY gained studies, and Global Cost-Effectiveness Analysis (GHCEA) Registry, which contains cost-per-DALY averted studies. We examined study characteristics including intervention type, sponsor, country, and primary disease, and also analysed the number of CEAs versus disease burden estimates for major diseases and conditions across three geographic regions.Results: We identified 6,438 cost-per-QALY and 543 cost-per-DALY studies published through 2016 and observed rapid growth in publication rates for both literatures. Cost-per-QALY studies were most likely to examine pharmaceuticals and interventions in high-income countries. Cost-per-DALY studies predominantly focused on infectious disease interventions and interventions in low and lower-middle income countries. We found discrepancies in the number of published CEAs for certain diseases and conditions in certain regions, suggesting “under-studied” areas (e.g., cardiovascular disease in Southeast Asia, East Asia, and Oceania and “overstudied” areas (e.g., HIV in Sub Saharan Africa) relative to disease burden in those regions.Conclusions: The number of cost-per QALY and cost-per-DALY analyses has grown rapidly with applications to diverse interventions and diseases. Discrepancies between the number of published studies and disease burden suggest funding opportunities for future cost-effectiveness research.
Motor performance in patients with knee osteoarthritis after 8-week home exercise program
Authors: Sokk Jelena , Rätsepsoo Monika , Kums Tatjana , Ereline Jaan , Haviko Tiit , Gapeyeva Helena , Pääsuke Mati 
Published: January 2018

On patients with knee osteoarthritis (OA) the muscle strength, gait and everyday activities performance capacity decreased, though patients care started many years before. Patients care includes supervised physio therapy sessions and home exercise performing. Research goal was to assess the improvement in patients with knee OA motor performance with home exercise program (HEP) 8-weeks before total knee arthroplasty (TKA). Hypothesis: 8-week HEP improve legs motor performance in patients with knee OA. Ten female patients with knee OA with the mean (±SE) age of 62.7±2.3 yrs; ten age- and gender-matched healthy controls with the mean (±SE) age of 62.6±1.1 yrs. Motor performance was assessed by isometric strength of the quadriceps femoris (QF) and hamstring (HM) muscles, gait, Five-Time-Sit-to-Stand (FTSTS) test and knee active range of motion (aROM) before and after 8-week HEP. Outcome was measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). After 8-week HEP, QF and HM isometric strength, knee aROM during flexion and the gait stride length for the involved leg increased (p<0.05) compared to pre-exercising level. The WOMAC score increased and FTSTS test time shortened (p<0.05) after 8-week HEP. Difference in measured parameters between the patients involved leg decreased as compared to uninvolved leg and controls. Study showed that after 8-week HEP improved involved leg thigh’s muscle strength, knee aROM, and stride length. Sit to stand test performance and patient’s self-assessed condition improved. In conclusion, HEP with at least 8 weeks should be recommended for patients with knee OA before TKA.