bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of caregivers and behavioral and psychological symptoms on nursing home placement of persons with Alzheimer’s disease: A matched case–control study
Authors: Porter Candace N , Miller Margaret C , Lane Marcia , Cornman Carol , Sarsour Khaled , Kahle-Wrobleski Kristin 
Published: August 2016

Objectives: Behavioral and psychological symptoms of dementia in individuals with Alzheimer’s disease and caregiver characteristics may influence the decision to provide care at home or in a nursing home, though few studies examine this association near the actual time of nursing home placement. Using a matched case–control design, this study investigates the association between (1) total Neuropsychiatric Inventory score, (2) the Neuropsychiatric Inventory-4 (an agitation/aggression subscale), and (3) individual domains of the Neuropsychiatric Inventory and nursing home placement. Methods: Data from the South Carolina Alzheimer’s disease Registry provides an opportunity to expand the literature by looking at cases at the time of nursing home care eligibility/placement and allowing for propensity-score-matched controls. Cases (n = 352) entered a nursing home within 6 months of study initiation; controls (n = 289) remained in the community. Registry data were combined with caregiver survey data, including the Neuropsychiatric Inventory. Conditional logistic regression was applied. Results: A 10% increase in the Neuropsychiatric Inventory score implied a 30% increase in odds of nursing home admission (odds ratio: 1.30; 95% confidence interval: 1.14–1.50), having married or male caregivers predicted nursing home placement. Cases versus controls were significantly more likely to have behavioral and psychological symptoms of dementia related to agitation/aggression 1 month prior to nursing home admission. Conclusion: Interventions targeting behavioral and psychological symptoms of dementia without available effective interventions in individuals with Alzheimer’s disease and caregiver support services are necessary to prevent or delay nursing home admission.
Effect of Calcium Phosphate–Hybridized Tendon Graft in Anatomic Single-Bundle ACL Reconstruction in Goats
Authors: Mutsuzaki Hirotaka , Fujie Hiromichi , Nakajima Hiromi , Fukagawa Makoto , Nomura Shunsuke , Sakane Masataka 
Published: August 2016

Background: We previously developed a novel technique using an alternate soaking process that improves tendon-bone healing by hybridizing the tendon graft with calcium phosphate (CaP). However, the effects of the CaP-hybridized tendon graft on anatomic single-bundle anterior cruciate ligament (ACL) reconstruction remain unclear. Purpose: To determine the effects of CaP-hybridized tendon grafts compared with untreated tendon grafts 6 months after anatomic single-bundle ACL reconstruction using a goat model. Study Design: Controlled laboratory study. Methods: Animals were divided into a CaP group (n = 5 goats) and a control group (n = 5 goats), and we analyzed (1) knee kinematics and in situ forces under applied anterior tibial loads of 50 N and internal tibial torque of 2.0 N·m in the grafts at full extension and at 60° and 90° of knee flexion, (2) the mean percentage of bone tunnel enlargement using computed tomography (CT), and (3) the histology of the tendon-bone interface. Results: The in situ forces under applied anterior tibial loads of 50 N at 60° and 90° of knee flexion in the CaP group were greater than those in the control group ( P < .05). The red safranin-O–stained area, indicating glycosaminoglycans in the cartilage layers at the joint aperture sites of the anterior femoral and posterior tibial bone tunnel, was greater in the CaP group than that in the control group ( P < .05). The lengths of the nonbonding gap area between the anterior femoral and posterior tibial bone tunnels in the control group were greater than those in the CaP group ( P < .05). No significant difference could be detected in the mean percentage of bone tunnel enlargement between the 2 groups. Conclusion: The CaP-hybridized tendon graft enhanced tendon-bone healing at the joint aperture site in both anterior femoral and posterior tibial tunnels 6 months after anatomic single-bundle ACL reconstruction in goats. The in situ forces under applied anterior tibial loads at greater flexion angles in the CaP group increased compared with controls. Clinical Relevance: Anatomic single-bundle ACL reconstruction using CaP-hybridized tendon grafts may lead to better postoperative knee function.
Accuracy of Different Methods for Assessing Erosive Tooth Wear
Authors: Bliggenstorfer S.E. , Lussi A. 
Published: August 2016

The detection of exposed dentine caused by erosive tooth wear is difficult. To the authors’ knowledge, there are no studies available on the impact of magnification and/or dye on the detection of erosive lesions. Therefore, the aim of this study was to investigate if the accuracy of assessing exposed dentine by the naked eye could be improved by using a microscope, dyeing, or a combination of both. The collected data were compared with the assessment of histological sections, which was considered the gold standard. A total of 70 teeth (24 teeth with slight erosion and 46 teeth with dentine involvement) showing different grades of erosive tooth wear were assessed 4 times by 17 examiners (9 aged <40 y, 8 aged ≥40 y). The first assessment was performed without magnification and without dye, the second assessment with magnification and without dye, the third assessment without magnification and with dye, and the fourth assessment with magnification and with dye. The examiners decided if dentine was exposed in the area of interest (positive test result) or not (negative test result). Subsequently, the teeth were histologically evaluated. Enamel was still present in 6 teeth and dentine was exposed in 64 teeth. Microscope magnification without dye performed the best, with 86% of all assessments being correct. The use of microscope magnification had a significant impact for dentists older than 40 y ( P = 0.02). The authors conclude that the assessment of exposed dentine was best when a microscope was used alone and that an additional dyeing of the samples did not improve performance. Knowledge Transfer Statement: Clinicians can use the results of this study when they assess erosive tooth wear. It will help clinicians to detect erosive tooth wear correctly, particularly the involvement of dentine. Using a microscope in the diagnostic process has a direct impact on the right assessment and consequently on prevention and/or minimally invasive treatment.
Status matters: The moderating role of perceived newcomer status in leader and coworker influences on challenging organizational citizenship behaviour
Authors: Wesche Jenny Sarah , Teichmann Eleni 
Published: August 2016

Organizations often fail to encourage employees, especially newcomers, to come forward with their suggestions and implement changes to improve the status quo, that is, to engage in challenging organizational citizenship behaviour (C-OCB). In order to be able to stimulate these behaviours from the outset and throughout a career a better understanding of contextual antecedents of C-OCB is needed. This study investigates how leaders and coworkers might facilitate C-OCB of employees ( N = 266) with varying perceived newcomer status. Results revealed positive main effects of coworker variables (team-member exchange and coworkers’ C-OCB) but not of empowering leadership on C-OCB. Perceived newcomer status had a negative main effect on C-OCB and moderated the effects of both coworker variables: the positive effect of team-member exchange on C-OCB was stronger for those with higher compared to those with lower perceived newcomer status. Conversely, the positive effect of coworkers’ C-OCB on participants’ C-OCB was stronger for those with lower compared to those with higher perceived newcomer status. These findings provide evidence for the important role of coworkers in addition to leaders for understanding C-OCB.
Stepwise iterative maximum likelihood clustering approach
Authors: Sharma Alok , Shigemizu Daichi , Boroevich Keith A. , López Yosvany , Kamatani Yoichiro , Kubo Michiaki , Tsunoda Tatsuhiko 
Published: August 2016

AbstractBackgroundBiological/genetic data is a complex mix of various forms or topologies which makes it quite difficult to analyze. An abundance of such data in this modern era requires the development of sophisticated statistical methods to analyze it in a reasonable amount of time. In many biological/genetic analyses, such as genome-wide association study (GWAS) analysis or multi-omics data analysis, it is required to cluster the plethora of data into sub-categories to understand the subtypes of populations, cancers or any other diseases. Traditionally, thek-means clustering algorithm is a dominant clustering method. This is due to its simplicity and reasonable level of accuracy. Many other clustering methods, including support vector clustering, have been developed in the past, but do not perform well with the biological data, either due to computational reasons or failure to identify clusters.ResultsThe proposed SIML clustering algorithm has been tested on microarray datasets and SNP datasets. It has been compared with a number of clustering algorithms. On MLL datasets, SIML achieved highest clustering accuracy and rand score on 4/9 cases; similarly on SRBCT dataset, it got for 3/5 cases; on ALL subtype it got highest clustering accuracy for 5/7 cases and highest rand score for 4/7 cases. In addition, SIML overall clustering accuracy on a 3 cluster problem using SNP data were 97.3, 94.7 and 100 %, respectively, for each of the clusters.ConclusionsIn this paper, considering the nature of biological data, we proposed a maximum likelihood clustering approach using a stepwise iterative procedure. The advantage of this proposed method is that it not only uses the distance information, but also incorporate variance information for clustering. This method is able to cluster when data appeared in overlapping and complex forms. The experimental results illustrate its performance and usefulness over other clustering methods. A Matlab package of this method (SIML) is provided at the web-linkhttp://www.riken.jp/en/research/labs/ims/med_sci_math/.
Prediction of redox-sensitive cysteines using sequential distance and other sequence-based features
Authors: Sun Ming-an , Zhang Qing , Wang Yejun , Ge Wei , Guo Dianjing 
Published: August 2016

Abstract
Background
Reactive oxygen species can modify the structure and function of proteins and may also act as important signaling molecules in various cellular processes. Cysteine thiol groups of proteins are particularly susceptible to oxidation. Meanwhile, their reversible oxidation is of critical roles for redox regulation and signaling. Recently, several computational tools have been developed for predicting redox-sensitive cysteines; however, those methods either only focus on catalytic redox-sensitive cysteines in thiol oxidoreductases, or heavily depend on protein structural data, thus cannot be widely used.

Results
In this study, we analyzed various sequence-based features potentially related to cysteine redox-sensitivity, and identified three types of features for efficient computational prediction of redox-sensitive cysteines. These features are: sequential distance to the nearby cysteines, PSSM profile and predicted secondary structure of flanking residues. After further feature selection using SVM-RFE, we developed Redox-Sensitive Cysteine Predictor (RSCP), a SVM based classifier for redox-sensitive cysteine prediction using primary sequence only. Using 10-fold cross-validation on RSC758 dataset, the accuracy, sensitivity, specificity, MCC and AUC were estimated as 0.679, 0.602, 0.756, 0.362 and 0.727, respectively. When evaluated using 10-fold cross-validation with BALOSCTdb dataset which has structure information, the model achieved performance comparable to current structure-based method. Further validation using an independent dataset indicates it is robust and of relatively better accuracy for predicting redox-sensitive cysteines from non-enzyme proteins.

Conclusions
In this study, we developed a sequence-based classifier for predicting redox-sensitive cysteines. The major advantage of this method is that it does not rely on protein structure data, which ensures more extensive application compared to other current implementations. Accurate prediction of redox-sensitive cysteines not only enhances our understanding about the redox sensitivity of cysteine, it may also complement the proteomics approach and facilitate further experimental investigation of important redox-sensitive cysteines.
Establishing a tree shrew model of systemic lupus erythematosus and cell transplantation treatment
Authors: Ruan Guang-Ping , Yao Xiang , Liu Ju-Fen , He Jie , Li Zi-An , Yang Jian-Yong , Pang Rong-Qing , Pan Xing-Hua 
Published: August 2016

AbstractBackgroundThe establishment of a tree shrew model for systemic lupus erythematosus (SLE) provides a new method to evaluate the pathogenesis of autoimmune diseases.MethodsEighty tree shrews were randomly divided into four groups receiving either an intraperitoneal injection of pristane, lipopolysaccharide (LPS), or pristane and LPS, or no injection. Three weeks after injection, the SLE model tree shrews were divided into the model group and the treatment group. Tree shrews in the treatment group and the normal control group were infused with umbilical cord mesenchymal stem cells (UC-MSCs). The cells were labeled with DiR. Two weeks after transplantation, three groups of tree shrews were analyzed for urine protein, serum antinuclear antibodies and antiphospholipid, and inflammatory cytokine antibody microarray detection. The heart, liver, spleen, lung, and kidney were collected from the three groups and subjected to hematoxylin and eosin (HE) staining and detection of renal immune complex deposition.ResultsHE staining indicated pathology in the model group. Red fluorescence revealed immune complex deposition in the kidneys from the model group.ConclusionsThe combined intraperitoneal injection of pristane and LPS is the best way to induce SLE pathological changes. The pathological changes improved after UC-MSC treatment.
RETRACTED ARTICLE: An augmented Riesz decomposition method for sharp estimates of certain boundary value problem
Authors: Wang Jiaofeng , Huang Bin , Yamini Nanjundan 
Published: August 2016

AbstractIn this paper, by using an augmented Riesz decomposition method, we obtain sharp estimates of harmonic functions with certain boundary integral condition, which provide explicit lower bounds of functions harmonic in a cone. The results given here can be used as tools in the study of integral equations.
Mathematical modeling and optimization of complex structures: a review
Authors: Riaz Samia , Chaudhry Qasim Ali , Siddiqui Sidra 
Published: August 2016

Book details
Pekka Neittaanmäki, Sergey Repin and Tero Tuovinen (Eds.).

Mathematical Modeling and Optimization of Complex Structures; Series: Computational Methods in Applied Sciences.

Springer International Publishing AG, Switzerland; 2016.
E-book, XXI, 328 pages, ISBN: 9783319235646, Hard-cover ISBN: 9783319235639, Library of Congress Control Number: 2015947948, DOI 10.1007/978-3-319-23564-6.
In situ and in-transit analysis of cosmological simulations
Authors: Friesen Brian , Almgren Ann , Lukić Zarija , Weber Gunther , Morozov Dmitriy , Beckner Vincent , Day Marcus 
Published: August 2016

AbstractModern cosmological simulations have reached the trillion-element scale, rendering data storage and subsequent analysis formidable tasks. To address this circumstance, we present a new MPI-parallel approach for analysis of simulation data while the simulation runs, as an alternative to the traditional workflow consisting of periodically saving large data sets to disk for subsequent ‘offline’ analysis. We demonstrate this approach in the compressible gasdynamics/N-body code Nyx, a hybrid $\mbox{MPI}+\mbox{OpenMP}$
MPI
+
OpenMP
code based on the BoxLib framework, used for large-scale cosmological simulations. We have enabled on-the-fly workflows in two different ways: one is a straightforward approach consisting of all MPI processes periodically halting the main simulation and analyzing each component of data that they own (‘in situ’). The other consists of partitioning processes into disjoint MPI groups, with one performing the simulation and periodically sending data to the other ‘sidecar’ group, which post-processes it while the simulation continues (‘in-transit’). The two groups execute their tasks asynchronously, stopping only to synchronize when a new set of simulation data needs to be analyzed. For both the in situ and in-transit approaches, we experiment with two different analysis suites with distinct performance behavior: one which finds dark matter halos in the simulation using merge trees to calculate the mass contained within iso-density contours, and another which calculates probability distribution functions and power spectra of various fields in the simulation. Both are common analysis tasks for cosmology, and both result in summary statistics significantly smaller than the original data set. We study the behavior of each type of analysis in each workflow in order to determine the optimal configuration for the different data analysis algorithms.
Complete genome sequence of thermophilic Bacillus smithii type strain DSM 4216T
Authors: Bosma Elleke F. , Koehorst Jasper J. , van Hijum Sacha A. F. T. , Renckens Bernadet , Vriesendorp Bastienne , van de Weijer Antonius H. P. , Schaap Peter J. , de Vos Willem M. , van der Oost John , van Kranenburg Richard 
Published: August 2016

AbstractBacillus smithii is a facultatively anaerobic, thermophilic bacterium able to use a variety of sugars that can be derived from lignocellulosic feedstocks. Being genetically accessible, it is a potential new host for biotechnological production of green chemicals from renewable resources. We determined the complete genomic sequence of the B. smithii type strain DSM 4216T, which consists of a 3,368,778 bp chromosome (GenBank accession number CP012024.1) and a 12,514 bp plasmid (GenBank accession number CP012025.1), together encoding 3880 genes. Genome annotation via RAST was complemented by a protein domain analysis. Some unique features of B. smithii central metabolism in comparison to related organisms included the lack of a standard acetate production pathway with no apparent pyruvate formate lyase, phosphotransacetylase, and acetate kinase genes, while acetate was the second fermentation product.
Reviews
Authors: Johnston Brittany , Chang Fiona 
Published: August 2016

Abstract
Mindfulness and the Arts Therapies: Theory And Practice, Laury Rappaport (ed.) (2013) London and Philadelphia: Jessica Kingsley Publishers, 352 pp., ISBN: 9781849059091, p/bk, $29.95
Unfolding Reflection from the Flowing Tao of Expressive Arts – The 11th International Expressive Arts Therapy Association Conference, Hong Kong, People’s Republic Of China, 6–10 October 2015
The arts and health: Moving beyond traditional medicine
Authors: Fleischer Stefanie , Grehan Mary 
Published: August 2016

Abstract
This article gathers evidence on the beneficial effects of the arts on health, health care and well-being. This was done by means of a review of research conducted in Ireland, the UK, Canada and Australia, dating from 1999 to 2014. The research outcomes are summarized and presented in sections on general health, older people and health care staff. A short section on ‘social prescribing’ and its increased use in primary health care is included in the section on mental health. In all sectors it was found that there are beneficial effects, especially for relieving stress and improving socialization. This review also includes the problems encountered in the research methodologies, as well as recommendations from researchers for future arts and health projects.
An alternative model of reflective teacher supervision
Authors: Göker Süleyman Davut 
Published: August 2016

Focusing on the promotion of reflectivity during practice teaching amongst teachers, this study aims to explore the impact of a reflective teacher supervision model (RTSM) developed by Goker (2006a) on the development of instructional skills of teachers. Two groups of elementary and secondary school teachers from different fields (24 in total) registered for an MA course, American University, Cyprus were compared to their development of instructional skills. The research approach used for this study was both quantitive and qualitative, which included: (a) conducting a sample lesson based on the pinciples of reflective teaching, (b) expessing results both with statistical data obtained from the pre test and post test results of the Clarity Observation Instrument (Metcalf, 1989) and using interviews and surveys, and anecdotal data. Findings have significant implications for how reflective supervision can be a means to develop instructional skills. Recommendations for teacher education programs and the student teachers are also made.
Locke, Kant, and Synthetic A Priori Cognition
Authors: Chance Brian A. 
Published: August 2016

AbstractThis paper attempts to shed light on three related issues that bear directly on our understanding of Locke and Kant. The first is whether Kant believes Locke merely anticipates his distinction between analytic and synthetic judgments or also believes Locke anticipates his notion of synthetic a priori cognition. The second is what we as readers of Kant and Locke should think about Kant’s view whatever it turns out to be, and the third is the nature of Kant’s justification for the comparison he draws between his philosophy and Locke’s. I argue (1) that Kant believes Locke anticipates both the analytic-synthetic distinction and Kant’s notion of synthetic a priori cognition, (2) that the best justification for Kant’s claim draws on Locke’s distinction between trifling and instructive knowledge, (3) that the arguments against this claim developed by Carson, Allison, and Newman fail to undermine it, and (4) that Kant’s own justification for his claim is quite different from what many commentators have thought it was (or should have been)
Unities of the Self: From Kant to Locke
Authors: Thiel Udo 
Published: August 2016

AbstractThis paper re-evaluates the relation between Kant and some of the most important philosophers traditionally labelled ‘empiricists’ on the topic of the unity of the self. Although Kant was familiar with at least some of the writings of the philosophers dealt with here, this paper’s concern is not with the question of influence or development, but with systematic aspects of Kant’s relation to the empiricist tradition. It is argued that Kant’s relationship to empiricist thought on this issue is more complex than one might be tempted to think. There are several different notions of unity within the empiricist tradition. Moreover, the philosophers considered here, thinkers as diverse as Locke, Condillac, Hume, Feder, Priestley, Reid and Tetens, work with more than one notion of the unity of the self, as does Kant. Locke’s contribution at the beginning of early modern thought about unity turns out to be closer to Kant’s account than that of other empiricists in that Kant develops further the Lockean idea of consciousness as a unifying activity. In general terms Kant’s account can be seen as continuous with the debate about unity among empiricist thinkers, it does not constitute a simple break with that tradition.