bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving web user satisfaction by ensuring usability criteria compliance
Authors: Suarez-Torrente Maria del Carmen , Conde-Clemente Patricia , Martínez Ana Belén , Juan Aquilino A. 
Published: March 2016

Purpose
– The purpose of this paper is to improve and facilitate the work of developers and usability evaluators by providing an adaptable and effective support. A well-defined set of criteria and a range of evaluation values for each criterion as well as a complete websites classification, will guide evaluators. A usability percentage and a list of prioritized criteria, adapted to the type of website by a new usability metric, will help developers to improve the website. This improvement will increase the degree of web user satisfaction.

Design/methodology/approach
– Having established and validated a new usability evaluation framework, several usability tools have been analyzed. None of them totally fulfills the requirements of the evaluation framework. As a result of being unable to customize any of them, a new one has been developed. A study of 42 enterprise websites in an economically depressed region of Europe was performed using the new tool. This study involved 42 evaluators and 118 web users. Users have evaluated the websites before and after the redesign. A end-user computing satisfaction model-based questionary was used to collect data about end-user satisfaction. The results validate the proposal.

Findings
– The study confirms that the proposed tool provides valuable information during the process of web development, evaluation and redesign. In adittion, it reveals that improving websites usability by ensuring criteria compliance has a positive effect on web users satisfaction.

Originality/value
– Unlike previous purposes, the proposed tool allows to evaluate any type of website with a well-defined set of evaluation criteria and specific criteria values. As outcomes, the tool provides the website usability degree and a list of criteria ordered by priority repair. These results are adapted to the specific type of website. This makes easier and more effective the redesign of the evaluated website.
Occurrence, heat and antibiotic resistance profile of Bacillus cereus isolated from raw cow and processed milk in Mezam Division, Cameroon
Authors: Tatsinkou Fossi Bertrand , Tatah Kihla Akoachere Jane‐Francis , Nchanji Gordon Takop , Wanji Samuel 
Published: March 2016

Bacillus cereus is the aetiologic agent of two distinct forms of food poisoning: the diarrhoeal and emetic syndromes. Little data exist on the prevalence of B. cereus in raw milk and milk products sold in Cameroonian towns. This study was aimed at investigating the occurrence, heat and antibiotic resistance of B. cereus isolated from raw milk and selected milk products in Mezam division, Cameroon. Bacillus cereus was isolated by inoculating samples onto mannitol‐egg yolk‐polymyxin B agar. Isolates were characterised morphologically and biochemically. The occurrence of B. cereus in raw milk (8.22%) was less than that in milk powder (13.33%). Bacillus cereus was not isolated from fermented milk. There was no significant difference (P < 0.05) between the B. cereus load in raw milk (2.6 × 103 cfu/mL) and milk powder (3.0 × 102 cfu/mL). All the isolates showed haemolysin activity and were sensitive to tetracycline, gentamicin, chloramphenicol and nalidixic acid, but resistant to penicillin, ampicillin and trimethoprim/sulphamethoxazole. The detection of drug‐resistant, haemolysin‐positive isolates should serve as a warning for an impending health hazard following consumption of untreated milk. Heat resistance of isolates was assessed by determining the decimal reduction time; D‐value (time to inactivate 90% of the B. cereus spores); and the heat sensitivity, z (temperature increase leads to a tenfold reduction in the D‐value). The values for D100 ranged from 0.5 to 3.5 min, and z‐values ranged from 10.0 to 32.6 °C. These results could be used in the dairy industry to evaluate the importance of heat treatment on B. cereus inactivation and calculation of process efficiency.
Effects of single and dual species herbivory on the behavioral responses of three thrips species to cotton seedlings
Authors: Silva Rehan , Walter Gimme H. , Wilson Lewis J. , Furlong Michael J. 
Published: March 2016

AbstractThis study investigated the olfactory responses of 3 thrips species [Frankliniella schultzei Trybom, F. occidentalis Pergrande and Thrips tabaci Lindeman (Thysanoptera: Thripidae)] to cotton seedlings [Gossypium hirsutum L. (Malvales: Malvaceae)] simultaneously damaged by different combinations of herbivores. Cotton seedlings were damaged by foliar feeding Tetranychus urticae Koch (Trombidiforms: Tetranychidae), Helicoverpa armigera Hübner (Lepidoptera: Noctuidae), Aphis gossypii Glover (Hemiptera: Aphididae) or root feeding Tenebrio molitor L. (Coleoptera: Tenebrionidae). Thrips responses to plants simultaneously damaged by 2 species of herbivore were additive and equivalent to the sum of the responses of thrips to plants damaged by single herbivore species feeding alone. For example, F. occidentalis was attracted to T. urticae damaged plants but more attracted to undamaged plants than to plants damaged by H. armigera. Plants simultaneously damaged by low densities of T. urticae and H. armigera repelled F. occidentalis but as T. urticae density increased relative to H. armigera density, F. occidentalis attraction to coinfested plants increased proportionally. Thrips tabaci did not discriminate between undamaged plants and plants damaged by H. armigera but were attracted to plants damaged by T. urticae alone or simultaneously damaged by T. urticae and H. armigera. Olfactometer assays showed that simultaneous feeding by 2 herbivores on a plant can affect predator–prey interactions. Attraction of F. occidentalis to plants damaged by its T. urticae prey was reduced when the plant was simultaneously damaged by H. armigera, T. molitor, or A. gossypii and F. schultzei was more attracted to plants simultaneously damaged by T. urticae and H. armigera than to plants damaged by T. urticae alone. We conclude that plant responses to feeding by 1 species of herbivore are affected by responses to feeding by other herbivores. These plant‐mediated interactions between herbivore complexes affect the behavioral responses of thrips which vary between species and are highly context dependent.
Efficacy of Neutral Electrolyzed Water, Quaternary Ammonium and Lactic Acid‐Based Solutions in Controlling Microbial Contamination of Food Cutting Boards Using a Manual Spraying Technique
Authors: Al‐Qadiri Hamzah M. , Ovissipour Mahmoudreza , Al‐Alami Nivin , Govindan Byju N. , Shiroodi Setareh Ghorban , Rasco Barbara 
Published: March 2016

AbstractBactericidal activity of neutral electrolyzed water (NEW), quaternary ammonium (QUAT), and lactic acid‐based solutions was investigated using a manual spraying technique against Salmonella Typhimurium, Escherichia coli O157:H7, Campylobacter jejuni, Listeria monocytogenes and Staphylococcus aureus that were inoculated onto the surface of scarred polypropylene and wooden food cutting boards. Antimicrobial activity was also examined when using cutting boards in preparation of raw chopped beef, chicken tenders or salmon fillets. Viable counts of survivors were determined as log10 CFU/100 cm2 within 0 (untreated control), 1, 3, and 5 min of treatment at ambient temperature. Within the first minute of treatment, NEW and QUAT solutions caused more than 3 log10 bacterial reductions on polypropylene surfaces whereas less than 3 log10 reductions were achieved on wooden surfaces. After 5 min of treatment, more than 5 log10 reductions were achieved for all bacterial strains inoculated onto polypropylene surfaces. Using NEW and QUAT solutions within 5 min reduced Gram‐negative bacteria by 4.58 to 4.85 log10 compared to more than 5 log10 reductions in Gram‐positive bacteria inoculated onto wooden surfaces. Lactic acid treatment was significantly less effective (P < 0.05) compared to NEW and QUAT treatments. A decline in antimicrobial effectiveness was observed (0.5 to <2 log10 reductions were achieved within the first minute) when both cutting board types were used to prepare raw chopped beef, chicken tenders or salmon fillets.
The relation between ischemia modified albumin levels and carotid intima media thickness in patients with rheumatoid arthritis
Authors: Uslu Ali U. , Kucuk Adem , Balta Sevket , Ozturk Cengiz , Arslan Sevket , Tekin Levent , Kucuksen Sami , Toker Aysun , Kayrak Mehmet 
Published: March 2016

AbstractBackgroundCardiovascular diseases, among which atherosclerotic heart disease, are known to be one of the most important mortality and morbidity causes in patients with rheumatoid arthritis (RA). Ischemia modified albumin (IMA) is a potential marker that can be used to assess atherosclerosis‐related myocardial ischemia. Another frequently used marker for the assessment of atherosclerotic lesions is the carotid intima media thickness (CIMT).AimTo evaluate the role that IMA has on atherosclerosis development and its clinical usability in patients with RA, by assessing the values of IMA and CIMT.Methods and materialsOur prospective study was conducted between June 2012 and March 2013 at the Rheumatology Department of Necmettin Erbakan Meram Medical School, Turkey. Fifty‐two RA patients, diagnosed according to the 1987 criteria of the American College of Rheumatology, and an age‐ and sex‐matched control group of 46 healthy subjects were included in this study.ResultsNo significant difference was detected between the groups with respect to age, sex and body mass index. In the patient group the IMA and CIMT values were found to be 0.37 ± 0.12 absorbance units (ABSU) and 0.80 ± 0.22 mm, respectively, while in the control group they were 0.31 ± 0.11 ABSU and 0.51 ± 0.18 mm, respectively. The IMA and CIMT values were significantly higher in the patient group (P = 0.022 and P < 0.0001, respectively). A positive correlation was found between IMA, CIMT and Disease Activity Score of 28 joints (P = 0.016 and P = 0.002, respectively).ConclusionSince the values of IMA were higher in the patient group compared to controls and because of its correlation with CIMT, we suggest the use of IMA as an early marker of atherosclerosis in RA patients.
Oral oxybutynin for the treatment of hyperhidrosis: outcomes after one‐year follow‐up
Authors: Millán‐Cayetano José Francisco , del Boz Javier , Rivas‐Ruiz Francisco , Blázquez‐Sánchez Nuria , Hernández Ibáñez Carlos , de Troya‐Martín Magdalena 
Published: March 2016

AbstractBackground/ObjectivesAlthough many treatments are available to address hyperhidrosis, the results are not always satisfactory. The aim of the study was to assess the effectiveness, optimal dosage regimen and long‐term safety of oral oxybutynin in the treatment of hyperhidrosis.MethodsA retrospective review was performed on 110 patients who underwent treatment for hyperhidrosis between February 2007 and December 2013. Their response to treatment was evaluated using the hyperhidrosis disease severity scale at baseline, 3 and 12 months. Additionally, the safety and effectiveness of different up‐dosing and fixed‐dose regimens were compared.ResultsAfter 3 months of treatment, 87 of the 110 patients (79%) had responded (63%), which was considered excellent. After 12 months, 63 patients (62%) continued to respond, and the response was considered excellent in 50%. Nine patients were lost to follow up between month 3 and 12. In total, 77 and 70% of the patients who responded at 3 and 12 months, respectively, reported mild adverse events. No serious adverse events were observed. Treatment adherence was significantly higher among patients following the individualised up‐dosing regimen.ConclusionOral oxybutynin may be an effective and safe option for the long‐term treatment of hyperhidrosis. To improve treatment adherence, oxybutynin dosing regimens should be individualised on the basis of the patient's tolerance and response.
Admission, management and outcomes of acute pancreatitis in intensive care
Authors: Russell Peter S. , Mittal Anhubav , Brown Lisa , McArthur Colin , Phillips Anthony J. R. , Petrov Max , Windsor John A. 
Published: March 2016

BackgroundA review of the management of acute pancreatitis (AP) at a tertiary intensive care unit (ICU) in Auckland, New Zealand, was published in 2004. This paper aims to update this series and identify changes in admission criteria, management and outcomes.MethodsA retrospective review of patients admitted to the Department of Critical Care Medicine, Auckland City Hospital, with AP from 2003 to 2014 was undertaken and data compared with the previous study (1988–2001).ResultsEighty‐four patients (male 53, mean ± SD age = 56.9 ± 15 years) with 85 admissions to ICU from 2003 to 2014 were compared with 112 patients in the previous study. Maori were over‐represented. Median duration of symptoms prior to admission to ICU decreased from 7 to 3 days. The proportion of total AP patients admitted to ICU halved and the mean Acute Physiology and Chronic Health Evaluation II score on admission decreased from mean 19.9 ± 8.2 SD to 15.4 ± 7.3 (P < 0.001). Two thirds of patients had persistent organ failure. The use of enteral feeding doubled from 46/112 (41%) to 71/85 (84%) (P < 0.001). The use of primary percutaneous drainage increased from 14/112 (13%) to 24/85 (28%) (P = 0.007). Rate of necrosectomy was similar (36/112 (32%) versus 20/85 (24%), P = 0.205), although minimally invasive necrosectomy was introduced. Overall hospital mortality decreased by 29% (P = 0.198).ConclusionThere have been changes to the admission criteria and management in line with evolving guidelines and, overall, outcomes have improved.
S‐Nitrosothiols as Platforms for Topical Nitric Oxide Delivery
Authors: Ganzarolli de Oliveira Marcelo 
Published: March 2016

AbstractNitric oxide (NO) is a small radical species involved in several fundamental physiological processes, including the control of vascular tone, the immune response and neuronal signalling. Endothelial dysfunction with the decreased NO bioavailability is the underlying cause of several diseases and has led to the development of a wide range of systemic NO donor compounds to lower the blood pressure and control hypertensive crises. However, several potential therapeutic actions of NO, not related to the cardiovascular system, demand exclusively local actions. Primary S‐nitrosothiols (RSNOs) are endogenously found NO carriers and donors and have emerged as platforms for the localized delivery of NO in topical applications. Formulations for this purpose have evolved from low molecular weight RSNOs incorporated in polymeric films, hydrogels and viscous vehicles, to polymeric RSNOs where the SNO moiety is covalently bound to the polymer backbone. The biological actions displayed by these formulations include the increase in dermal vasodilation, the acceleration of wound healing, the killing of infectious microorganisms and an analgesic action against inflammatory pain. This MiniReview focuses on the state of the art of experimental topical formulations for NO delivery based on S‐nitrosothiols and their potential therapeutic applications.
FXIIa inhibitor rHA‐Infestin‐4: Safe thromboprotection in experimental venous, arterial and foreign surface‐induced thrombosis
Authors: May Frauke , Krupka Jennifer , Fries Marion , Thielmann Ina , Pragst Ingo , Weimer Thomas , Panousis Con , Nieswandt Bernhard , Stoll Guido , Dickneite Gerhard , Schulte Stefan , Nolte Marc W. 
Published: March 2016

SummaryHaemostasis including blood coagulation is initiated upon vessel wall injury and indispensable to limit excessive blood loss. However, unregulated pathological coagulation may lead to vessel occlusion, causing thrombotic disorders, most notably myocardial infarction and stroke. Furthermore, blood exposure to foreign surfaces activates the intrinsic pathway of coagulation. Hence, various clinical scenarios, such as extracorporeal membrane oxygenation, require robust anticoagulation consequently leading to an increased bleeding risk. This study aimed to further assess the antithrombotic efficacy of the activated factor XII (FXIIa) inhibitor, rHA‐Infestin‐4, in several thrombosis models.In mice, rHA‐Infestin‐4 decreased occlusion rates in the mechanically‐induced arterial (Folt's) and the FeCl3‐induced venous thrombosis model. rHA‐Infestin‐4 also protected from FeCl3‐induced arterial thrombosis and from stasis‐prompted venous thrombosis in rabbits. Furthermore, rHA‐Infestin‐4 prevented occlusion in the arterio‐venous shunt model in mice and rabbits where thrombosis was induced via a foreign surface. In contrast to heparin, the haemostatic capacity in rabbits was unaffected by rHA‐Infestin‐4.Using rodent and non‐rodent species, our data demonstrate that the FXIIa inhibitor rHA‐Infestin‐4 decreased arterial, venous and foreign surface‐induced thrombosis without affecting physiological haemostasis. Hence, we provide further evidence that targeting FXIIa represents a potent yet safe antithrombotic treatment approach, especially in foreign surface‐triggered thrombosis.
Post‐transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation
Authors: Stokes Jessica , Hoffman Emely A. , Zeng Yi , Larmonier Nicolas , Katsanis Emmanuel 
Published: March 2016

SummaryAdvances in haploidentical bone marrow transplantation (h‐BMT) have drastically broadened the treatment options for patients requiring BMT. The possibility of significantly reducing the complications resulting from graft‐versus‐host disease (GvHD) with the administration of post‐transplant cyclophosphamide (PT‐CY) has substantially improved the efficacy and applicability of T cell‐replete h‐BMT. However, higher frequency of disease recurrence remains a major challenge in h‐BMT with PT‐CY. There is a critical need to identify novel strategies to prevent GvHD while sparing the graft‐versus‐leukaemia (GvL) effect in h‐BMT. To this end, we evaluated the impact of bendamustine (BEN), given post‐transplant, on GvHD and GvL using clinically relevant murine h‐BMT models. We provide results indicating that post‐transplant bendamustine (PT‐BEN) alleviates GvHD, significantly improving survival, while preserving engraftment and GvL effects. We further document that PT‐BEN can mitigate GvHD even in the absence of Treg. Our results also indicate that PT‐BEN is less myelosuppressive than PT‐CY, significantly increasing the number and proportion of CD11b+Gr‐1hi cells, while decreasing lymphoid cells. In vitro we observed that BEN enhances the suppressive function of myeloid‐derived suppressor cells (MDSCs) while impairing the proliferation of T‐ and B‐cells. These results advocate for the consideration of PT‐BEN as a new therapeutic platform for clinical implementation in h‐BMT.
Nonsteroidal anti‐inflammatory drugs enhance IgE‐mediated activation of human basophils in patients with food anaphylaxis dependent on and independent of nonsteroidal anti‐inflammatory drugs
Authors: Pascal M. , Muñoz‐Cano R. , Milà J. , Sanz M. L. , Diaz‐Perales A. , Sánchez‐López J. , García‐Moral A. , Juan M. , Valero A. , Yagüe J. , Picado C. , Bartra J. 
Published: March 2016

SummaryBackgroundNonsteroidal anti‐inflammatory drugs (NSAIDs) act as cofactors worsening the allergic reactions induced by food allergens.AimThe aim of this study was to evaluate the effect of both lysine acetylsalicylate (L‐ASA) (non‐selective cyclooxygenase (COX) inhibitor) and valdecoxib (selective COX‐2 inhibitor) in basophils activated by peach lipid transfer protein (Pru p 3) in patients with food‐dependent NSAID‐induced anaphylaxis (FDNIA).MethodsTwenty Pru p 3‐allergic patients with FDNIA group, eleven peach anaphylaxis not exacerbated by NSAIDs (no‐NSAID group) and 5 healthy volunteers were recruited. Basophil activation (BA) was measured as expression of CD63 (Flow2CAST™; Bühlmann®), after stimulation with Pru p 3, both alone and in combination with L‐ASA (1.13, 3.38 and 6.78 mm) or valdecoxib (0.87, 7.8 and 31.25 μm).ResultsBasophils from no‐NSAID group were significantly more reactive and sensitive to Pru p 3 than those from the FDNIA group. In both groups, an increase in BA was observed when basophils were exposed to Pru p 3 and L‐ASA. In the FDNIA group, valdecoxib partially terminates the BA induced by Pru p 3, whereas in the no‐NSAID group, a dual effect was observed depending on the concentration tested.ConclusionsThis study indicates that subjects with food‐induced anaphylaxis differ from FDNIA subjects in the higher reactivity and sensitivity of their basophils to allergen challenge. We have shown a direct effect of NSAIDs on basophils using a human model of FDNIA. Our results also suggest that selective COX2 inhibitors might be a safe alternative. BA test may be a useful tool in the study of the pathogenic mechanism of the cofactor phenomenon.
Seed release in a changing climate: initiation of movement increases spread of an invasive species under simulated climate warming
Authors: Teller Brittany J. , Zhang Rui , Shea Katriona 
Published: March 2016

AbstractAimReliable estimates of how species will move under future climatic conditions are lacking, and the ability of species to track suitable habitat under climate change is strongly predicated on dispersal. In wind‐dispersed plants, initiation of movement by maternal seed release characteristics can affect the ultimate shape of the dispersal kernel. If seed dispersal traits respond to altered local abiotic conditions induced by climate change during development, the effects could have major impacts on projections of future population spread.LocationCentral Pennsylvania, USA.MethodsTo quantify how seed release characteristics might be affected by climate change, we experimentally manipulated temperature in a field study of the wind‐dispersed, invasive plant Carduus nutans (Asteraceae). We quantified seed release in a series of trials conducted in a full‐size experimental wind tunnel, and we examined the effect of the probability of seed release on the projected population spread rate (c*).ResultsExperimental warming over the growing season significantly increased the probability of seed release in wind tunnel trials by 7%. When these data were incorporated into matrix integro‐differential equation models of population spread for this species, the measured increase in seed release, combined with previously reported increases in plant height, resulted in a projected increase in the population spread rate of C. nutans of 38% per year due to increased temperature.Main conclusionsIgnoring altered seed release dynamics significantly underestimates the increase in potential spread rate by 11%. This increase could allow this species to reach suitable habitat more quickly than expected from existing models of population spread, and could require management timing to shift in the future. More generally, our results suggest that models of future distributions of other wind‐dispersed species that do not include information about species' dispersal responses to climate may incur significant errors and could result in poorly applied management or inadequate spatial risk assessment.