bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the rates and characteristics of gamma hydroxybutyrate (GHB)‐related death in Australia, 2001–2023
Authors: Darke Shane , Duflou Johan , Chrzanowska Agata , Farrell Michael , Lappin Julia , Peacock Amy 
Published: September 2024

AbstractIntroductionIn recent years gamma hydroxybutyrate (GHB) use appears to have increased. This study aimed to determine: (i) population rates of GHB‐related death in Australia, 2001–2021; and (ii) whether there have been changes in the characteristics of GHB‐related death in Australia over the period 2001–2023.MethodsRetrospective study of all Australian cases in which GHB was a mechanism contributory to death retrieved from the National Coronial Information System (n = 217). Joinpoint regression models were used to analyse trends in overall rates.ResultsDeath rates were stable between 2001 and 2015 (‘stable period’) (annual percent change [APC] = 3.7) but showed marked acceleration between 2016 and 2021 (‘accelerated period’) (APC = 44.4). Circumstances of death were: unintentional toxicity (81.6%), intentional toxicity (5.1%), self‐harm (6.0%), traumatic injury (7.4%). Compared to the stable period, later cases were slightly older (34.2 vs. 30.7 years, p < 0.05), less likely to be employed (odds ratio [OR] 0.4), but more likely to have substance use problems (OR 3.9), a history of injecting drug use (OR 3.5), mental health problems (OR 3.6), and to have present in their blood at toxicological screening opioids (OR 3.2) and hypnosedatives (OR 3.7). The median blood GHB concentration was 170 mg/L, (range 0–3210), which did not change significantly. There were no differences in major organ pathology, but the proportion with aspiration pneumonia declined (OR 0.4).Discussion and ConclusionsGHB‐related death rates increased from 2016, accompanied by changes in case characteristics. In recent years GHB use appears to have extended to a population more likely to have substance use problems and use other respiratory depressants.
Twenty‐four‐month effortful control predicts emerging autism characteristics
Authors: Perry Roisin C. , Johnson Mark H. , Charman Tony , Pascoe Greg , Tolmie Andrew , Thomas Michael S. C. , Dumontheil Iroise , Jones Emily J. H. ,   The BASIS Team
Published: September 2024

AbstractLongitudinal research can assess how diverging development of multiple cognitive skills during infancy, as well as familial background, are related to the emergence of neurodevelopmental conditions. Sensorimotor and effortful control difficulties are seen in infants later diagnosed with autism; this study explored the relationships between these skills and autism characteristics in 340 infants (240 with elevated familial autism likelihood) assessed at 4–7, 8–10, 12–15, 24, and 36 months. We tested: (1) the relationship between parent‐reported effortful control (Rothbart's temperament questionnaires) and sensorimotor skills (Mullen Scales of Early Learning), using random intercept cross‐lagged panel modelling; (2) whether household income and maternal education predicted stable individual differences in cognition; (3) sensorimotor and effortful control skills as individual and interactive predictors of parent‐reported autism characteristics (Social Responsiveness Scale) at 3 years, using multiple regression; and (4) moderation of interactions by familial likelihood. Sensorimotor skills were longitudinally associated with effortful control at the subsequent measurement point from 12–15 months. Socioeconomic status indicators did not predict stable between‐infant differences in sensorimotor or effortful control skills. Effortful control skills were longitudinally related to 3‐year autism characteristics from the first year of life, with evidence for an interaction with sensorimotor skills at 24 months. Effects of effortful control increased with age and were particularly important for infants with family histories of autism. Results are discussed in relation to different theoretical frameworks: Developmental Cascades and Anterior Modifiers in the Emergence of Neurodevelopmental Disorders. We suggest a role for 24‐month effortful control in explaining the emergent autism phenotype.Research Highlights
Sensorimotor skills longitudinally predicted effortful control from 12–15 months onward but effortful control did not longitudinally predict sensorimotor skills during infancy.
Measures of effortful control skills taken before the age of 1 predicted continuous variation in autism characteristics at 36 months, with associations increasing in strength with age.
Effortful control (measured at 12–15 and 24 months) was a stronger predictor of 36‐month autism characteristics in infants with elevated familial likelihood for autism.
The relationship between 24‐month sensorimotor skills and 36‐month autism characteristics was stronger in infants with weaker effortful control skills.
Cost‐effectiveness of the tandem t: Slim X2 with control‐IQ technology automated insulin delivery system in children and adolescents with type 1 diabetes in Sweden
Authors: Adolfsson Peter , Heringhaus Alina , Sjunnesson Karin , Mehkri Laila , Bolin Kristian 
Published: September 2024

AbstractAimsThe present analysis estimated the cost‐effectiveness of treatment with the Tandem t: slim X2 insulin pump with Control IQ technology (CIQ) in children with type 1 diabetes in Sweden.MethodsA four‐state Markov model and probabilistic sensitivity analyses (PSA) were used to assess the cost‐effectiveness of CIQ use compared with treatment with multiple daily insulin injections (MDI) or continuous subcutaneous insulin infusion (CSII) in conjunction with CGM. Data sources included clinical input data from a recent retrospective, observational study, cost data from local diabetes supply companies and government agencies, and published literature. Outcomes measures were quality adjusted life years (QALYs) at 10, 20 and 30‐year time horizons based on cost per QALY and incremental cost‐effectiveness ratio (ICER).ResultsA total of 84 type 1 diabetes children were included (CIQ, n = 37; MDI, n = 19; CSII, n = 28). For all time horizons, the use of CIQ was a dominant strategy (e.g. more effective and less costly) compared with MDI or CSII use: 10‐year ICER, SEK ‐88,010.37 and SEK ‐91,723.92; 20‐year ICER, SEK −72,095.33 and SEK −87,707.79; and 30‐year ICER, SEK −65,573.01 and SEK ‐85,495.68, respectively. PSA confirmed that CIQ use was less costly compared with MDI and CSII.ConclusionsInitiation of CIQ use in children with type 1 diabetes is cost‐saving, besides previously shown improved glycaemic control, and increased quality of life. Further investigations are needed to more fully elucidate the cost‐effectiveness of these technologies in different countries with existing differences in payment models.
Japanese version of the Equity Sensitivity Inventory Adapted for Married Couples
Authors: Kanazawa Yuki , Shibayama Taiga 
Published: September 2024

AbstractObjectiveThis study aimed to modify the Japanese version of the Justice Sensitivity Inventory for married couples raising children to help them become more aware of their partner's sensitivity to fairness.BackgroundIn Japan, couples with children tend to have prejudice about the division of roles, perceiving each other based on the fairness of child care, housework, and work.MethodOur participants comprised married couples who lived together with a child aged between 1 month and 3 years. A Web company commissioned a survey, with 1,200 and 500 participants included in the first and second rounds of testing, respectively, conducted 1 week apart. We examined the correlation between each subscale of the Japanese version of the Equity Sensitivity Inventory Adapted for Married Couples (J‐ESIA), the Japanese version of the Quality Marriage Index (J‐QMI), the Japanese version of the Interpersonal Reactivity Index (J‐IRI), and the short form of the Japanese Big‐Five Scale (S‐JBFS). Exploratory and confirmatory factor analyses were conducted.ResultsThree factors were identified: ES‐Perpetrator, ES‐Victim, and ES‐Beneficiary. Cronbach's α for each subscale ranged from .95 to .96.ConclusionA couple‐specific correlation was confirmed for comorbid validity.ImplicationsCouples can recognize each other's sensitivity to fairness and bring about behavioral change in their relationship.
A sedimentary DNA perspective about the influence of environmental and food‐web changes on the microbial eukaryotic community of Lake Biwa
Authors: Capo Eric , Picard Maïlys , Nakane Kai , Kuwae Michinobu , Bertilsson Stefan , Kagami Maiko , Liu Xin , Sakai Yoichiro , Tsugeki Narumi 
Published: September 2024

Abstract

The impacts of environmental change on Lake Biwa have been explored for decades, with water monitoring and palaeolimnological studies revealing how environmental forcing, including climate warming, eutrophication, water level manipulation and human manipulation of fish populations, has influenced the food web of Lake Biwa. However, these studies have rarely accounted for microbial food‐web components. This knowledge gap is mostly due to the lack of time series spanning more than a couple of decades, coupled with the high taxonomical expertise required to identify organisms belonging to very diverse groups.

The use of a sedimentary DNA approach allows for the reconstruction of past changes in the diversity, composition and structure of the microbial eukaryotic community of aquatic systems. The application of 18S metabarcoding has been proven successful to describe the response of unicellular eukaryotes (protists) and aquatic fungi in lake ecosystems, encompassing a large taxonomic and functional diversity such as phototrophs, heterotrophs and mixotrophs.

We applied 18S metabarcoding to 31 sediment core samples from Lake Biwa, spanning the past 100 years and explored the response of microbial eukaryotic communities to changes in multiple environmental stressors, including nutrient levels, lake water level, climate, as well as fish and zooplankton biomass for the period 1973–2010.

We found that the manipulation of the water level and changes in fish community composition were the primary factors impacting (indirectly) the structure of the lake microbial eukaryotic community with minor, but significant, effects of climate warming and phosphorus levels. Co‐occurrence network analysis highlighted the potential food web impacts on the microbial eukaryotic community, suggesting that organisms from this compartment were impacted by both bottom‐up and top‐down processes.
Otolith reliability is context‐dependent for estimating warming and CO2 acidification impacts on fish growth
Authors: Tang Bangli , Ding Liuyong , Ding Chengzhi , He Dekui , Su Haojie , Tao Juan 
Published: September 2024

AbstractOtoliths are frequently used as proxies to examine the impacts of climate change on fish growth in marine and freshwater ecosystems worldwide. However, the large sensitivity differences in otolith growth responses to typical changing environmental factors (i.e., temperature and CO2 concentration), coupled with unclear drivers and potential inconsistencies with fish body growth, fundamentally challenge the reliability of such otolith applications. Here, we performed a global meta‐analysis of experiments investigating the direct effects of warming (297 cases) and CO2 acidification (293 cases) on fish otolith growth and compared them with fish body growth responses. Hierarchical models were used to assess the overall effect and quantify the influence of nine explanatory factors (e.g., fish feeding habit, life history stage, habitat type, and experimental amplitude and duration). The overall effects of warming and acidification on otolith growth were positive and significant, and the effect size of warming (effect size = 0.4003, otolith size of the treatment group increased by 49.23% compared to that of the control group) was larger than that of acidification (0.0724, 7.51%). All factors examined contributed to the heterogeneity of effect sizes, with larger responses commonly observed in carnivorous fish, marine species, and young individuals. Warming amplitudes and durations and acidification amplitudes increased the effect sizes, while acidification durations decreased the effect sizes. Otolith growth responses were consistent with, but greater than, fish body growth responses under warming. In contrast, fish body growth responses were not significant under acidification (effect size = −0.0051, p = .6185) and thus cannot be estimated using otoliths. Therefore, our study highlights that the reliability of applying otoliths to examine climate change impacts is likely varied, as the sensitivity of otolith growth responses and the consistency between the growth responses of otoliths and fish bodies are context‐dependent.
‘But … Would I Be Able to Toast With Friends?’ When Service Users Ask for New Care Pathways
Authors: Rocelli Michele , Aquili Ludovica , Palmieri Arianna , Romaioli Diego , Ferrari Lea , Faccio Elena 
Published: September 2024

ABSTRACTIntroductionThe WHO European Mental Health Action Plan (2013–2030) emphasises the need to generate services that are more inclusive and attentive to the co‐construction of care practices. This exploratory research investigates the needs of young substance abusers shown during their stay in residential communities; in particular, it explores the idea that treatment may include a new phase focused on how to manage moderate or controlled alcohol intake during residential care. Interviews with young ex‐users open up critical reflections on complete abstinence programmes from all substances, including alcohol, as a prerequisite for discharge and also provide examples of how to co‐design a plan for mindful drinking.MethodsFourteen young adults, aged 19–32 years, non‐alcoholists, treated at rehab in Fermo, in central Italy, were interviewed during a programme between 6 and 18 months of period. They were asked about exploring needs in preparation for the conclusion of the rehabilitation pathway. From this exploration emerged the need to introduce controlled alcohol intake during the rehabilitation stay. This request became the focus of the semi‐structured interviews.ResultsThree main themes emerged, which are as follows: (1) difficulties in integrating the new identity with the past of consumption, (2) resistance to the idea of total abstinence in social relations and (3) uncertainties about post‐community behaviour regarding alcohol intake. At the same time, three unexpected needs were expressed: (1) test the personal knowledge and skills on how to manage the alcohol intake, (2) receive support during the residential path to build up self‐control competence given the post‐discharge period and (3) build a personalised therapeutic path together with the supervisor and the operators while still at the rehab, according to the realistic lifestyle and routine outside the rehab.ConclusionsThis research highlights the importance of personalising treatment based on each user's needs, going far beyond the standardised treatments for users previously considered unable of self‐control and self‐determination. For that purpose, the relationship between the users and the operators might be privileged, as it is able to cover the specific needs aimed for the new identity.Involving the ParticipantsThe research sparked a discussion within the community, involving and initiating an open dialogue between the operators and the users, allowing them to focus on certain innovative strategies offered by the service, putting the users' needs at the very centre of the attention. The results were compared and discussed actively with the participants involved.
Analyse des différences entre les régimes de protection des travailleurs domestiques de divers pays à l'aide du cadre du régime des politiques publiques
Authors: PAUL Anju Mary 
Published: September 2024

RésuméLa main‐d'œuvre domestique est l'une des catégories de travailleurs les plus précaires et les moins protégées au monde. La situation est cependant très variable selon les pays. S'appuyant sur le cadre du régime de politiques publiques, l'autrice montre que ces différences de degré de protection juridique entre pays s'expliquent par des variations en matière d'idées, d'institutions et de groupes d'intérêts. Elle postule que la protection des travailleurs domestiques ne peut être forte que si ces trois éléments sont présents et favorables à ces travailleurs. Elle montre ainsi pourquoi les régimes de protection en place en Afrique du Sud, au Pakistan, à Singapour et en Suède sont faibles ou incomplets.
Feasibility, acceptability, and perceived effectiveness of weighted blankets during paediatric dental care
Authors: Stein Duker Leah I. , McGuire Riley , Hernandez Jocelyn , Goodman Elizabeth , Polido José C. 
Published: September 2024

AbstractBackgroundWeighted blankets are one method to provide deep pressure touch sensations, which are associated with a calming effect on the nervous system. Weighted blankets have been reported to elicit a calming effect during stressful dental encounters and routine prophylactic visits in older adolescents and adults. Preliminary research suggests that weighted blankets are safe and feasible for children in both hospital and home settings; this, however, has not yet been examined in a paediatric dental environment.AimTo examine the feasibility, acceptability, and perceived effectiveness of a weighted blanket during paediatric dental care.DesignThis cross‐sectional study examined child, caregiver, and dentist‐reported responses to survey questions asking about their experience with the weighted blanket during care (n = 20 each per child and caregiver group, n = 9 dentists).ResultsThe use of a weighted blanket is feasible, acceptable, and appropriate as reported by caregivers and dentists (means ≥ 4.70 on the Feasibility of Intervention, Acceptability of Intervention, and Intervention Appropriateness Measures). Few problems were described, and all groups overwhelmingly responded with enthusiasm, noted the blanket's potential for future use, and perceived that a weighted blanket improved care (means ≥ 4.10).ConclusionsStudy findings support the feasibility and acceptability of using a weighted blanket during routine, noninvasive paediatric dental care.
Barriers and Facilitators to Sustainable Technology Implementation in Care for People With Disabilities—Real World Data From a Three‐Year Implementation Programme
Authors: van der Weegen Sanne , van der Poel Agnes , Kagenaar Eva , Bierhoff Ilse , Boon Brigitte 
Published: September 2024

ABSTRACTBackgroundImplementation issues often impede the realisation of the potential benefits of technology in disability care organisations for people with disabilities. Therefore, we conducted a longitudinal study to gain insights into the barriers and facilitators to implementation.MethodsFrom 2019 to 2022, data were collected using questionnaires and interviews during 28 implementation projects in 26 disability care organisations.ResultsBarriers and facilitators were identified using 9 themes and 26 subthemes. The main themes identified were finances, disability care organisations, internal collaborations, external collaborations, technology, care staff, project teams, people with disabilities, and context. Most factors mentioned as barriers in one organisation were mentioned as facilitators in others. This suggests that barriers can be resolved to improve implementation.ConclusionA large number of barriers and facilitators spanning the organisation suggests that the implementation of technology should be considered an organisational reform. Acting upon them is crucial for the successful implementation of technology.
Genetic interactions and pleiotropy in metabolic diseases: Insights from a comprehensive GWAS analysis
Authors: Shen Jing , Pan Julong , Yu Gang , Cai Hui , Xu Hua , Yan Hanfei , Feng Yu 
Published: September 2024

AbstractThis study offers insights into the genetic and biological connections between nine common metabolic diseases using data from genome‐wide association studies. Our goal is to unravel the genetic interactions and biological pathways of these complex diseases, enhancing our understanding of their genetic architecture. We employed a range of advanced analytical techniques to explore the genetic correlations and shared genetic variants of these diseases. These methods include Linked Disequilibrium Score Regression, High‐Definition Likelihood (HDL), genetic analysis combining multiplicity and annotation (GPA), two‐sample Mendelian randomization analyses, analysis under the multiplicity‐complex null hypothesis (PLACO), and Functional mapping and annotation of genetic associations (FUMA). Additionally, Bayesian co‐localization analyses were used to examine associations of specific loci across traits. Our study discovered significant genomic correlations and shared loci, indicating complex genetic interactions among these metabolic diseases. We found several shared single nucleotide variants and risk loci, notably highlighting the role of the immune system and endocrine pathways in these diseases. Particularly, rs2476601 and its associated gene PTPN22 appear to play a crucial role in the connection between type 2 diabetes mellitus, hypothyroidism/mucous oedema and hypoglycaemia. These findings enhance our understanding of the genetic underpinnings of these diseases and open new potential avenues for targeted therapeutic and preventive strategies. The results underscore the importance of considering pleiotropic effects in deciphering the genetic architecture of complex diseases, especially metabolic ones.
Effect of Discontinuation of Supportive Periodontal Therapy on Periodontal Status—A Retrospective Study
Authors: Kocher Thomas , Lösler Karoline , Pink Christiane , Grabe Hans Jörgen , Holtfreter Birte 
Published: September 2024

ABSTRACTAimTo assess the impact of active (APT) and supportive periodontal therapy (SPT) on the change in probing depth (PD) and annual tooth loss in partially and fully compliant and drop‐out patients.Material and MethodsData of 280 periodontally treated partially and fully compliant (regular supportive visits, SPT duration 5.5 ± 4.5 years) and 55 drop‐out patients (SPT and drop‐out duration 8.3 ± 3.8 years, only drop‐out duration 5.3 ± 3.7 years) were recorded. PD data and the number of teeth present at the start of APT (T1) and at the start of SPT (T2) were taken from the patient files and evaluated at the time of the final examination (T3).ResultsAnnual tooth loss during SPT was significantly higher (p < 0.001) in drop‐out patients than in partially and fully compliant patients (0.31 ± 0.50 vs. 0.19 ± 0.55, respectively). In partially and fully compliant and drop‐out patients, the mean PD (all available site data) decreased significantly between T1 (3.61 ± 0.82 vs. 3.70 ± 0.73 mm) and T2 (2.68 ± 0.40 vs. 2.76 ± 0.42 mm), while the values increased again slightly up to T3 (2.74 ± 0.41 vs. 2.99 ± 0.75 mm).ConclusionsIn partially and fully compliant patients, SPT had a positive impact on PD stability and medium‐term tooth preservation. In contrary to expectations, drop‐out patients, PD did not return to baseline values, although PD stability was not achieved.