bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Frequency Monitoring and Nitrate Sourcing Reveals Baseflow and Stormflow Controls on Total Dissolved Nitrogen and Carbon Export Along a Rural‐Urban Gradient
Authors: Delesantro Joseph M. , Duncan Jonathan M. , Riveros‐Iregui Diego , Whitmore Keridwen M. , Band Lawrence E. 
Published: October 2024

AbstractEfforts to reduce nitrogen and carbon loading from developed watersheds typically target specific flows or sources, but across gradients in development intensity there is no consensus on the contribution of different flows to total loading or sources of nitrogen export. This information is vital to optimize management strategies leveraging source reductions, stormwater controls, and restorations. We investigate how solute loading and sources vary across flows and land‐use using high frequency monitoring and stable nitrate isotope analysis from five catchments with different sanitary infrastructure, along a gradient in development intensity. High frequency monitoring allowed estimation of annual loading and attribution to storm versus baseflows. Nitrate loads were 16 kg/km2/yr. from the forested catchment and ranged from 68 to 119 kg/km2/yr., across developed catchments, highest for the septic served site. Across developed catchments, baseflow contributions ranged from 40% of N loading to 75% from the septic served catchment, and the contribution from high stormflows increased with development intensity. Stormflows mobilized and mixed many surface and subsurface nitrate sources while baseflow nitrate was dominated by fewer sources which varied by catchment (soil, wastewater, or fertilizer). To help inform future sampling designs, we demonstrate that grab sampling and targeted storm sampling would likely fail to accurately predict annual loadings within the study period. The dominant baseflow loads and subsurface stormflows are not treated by surface water management practices primarily targeted to surface stormflows. Using a balance of green and gray infrastructure and stream/riparian restoration may target specific flow paths and improve management.
Seismo‐Acoustic Characterization of the 2018 Sierra Negra Caldera Resurgence and Fissure Eruption in the Galápagos Islands
Authors: Ortiz Hugo D. , Matoza Robin S. , Bernard Benjamin , De Negri Rodrigo , Ruiz Mario C. 
Published: October 2024

AbstractThe 2018 eruption of Sierra Negra volcano, Galápagos, Ecuador has provided new insights into the mechanisms of caldera resurgence, subsidence, and fissuring at basaltic shield volcanoes. Here, we integrate local (∼0.4 km) seismo‐acoustic records and regional (∼85 km) infrasound array data to present new observations of the 2018 Sierra Negra eruption with improved time and spatial resolutions. These observations include: air‐to‐ground coupling ∼2 hr before the time of the eruption onset, migration of the infrasound tremor from 22:54 June 26 to 12:31 June 27 UT (all times in UT), and persistent infrasound detections during the weeks between 5 July and 18 August from an area that does not coincide with the previously documented eruptive fissures. We interpret air‐to‐ground coupling as infrasound tremor generated in the nearby fissures before the main eruptive phase started, although ambiguity remains in interpreting a single seismic‐infrasonic sensor pair. The progressive location change of the infrasound tremor agrees with the migration of the eruption down the north flank of Sierra Negra at a rate of ∼0.15 ± 0.04 m/s. The weeks‐long persistent detections coincide with a region that has thermal anomalies, co‐eruptive deformation, lava fields, and geological features that could be interpreted as multiple lava tube skylights. Our observations and interpretations provide constraints on the mechanisms underlying fissure formation and magma emplacement at Sierra Negra.
Subsurface Marine Heatwaves in the South China Sea
Authors: Yao Yulong , Wang Chunzai 
Published: October 2024

AbstractMarine heatwaves (MHWs), extreme warm ocean temperature events, greatly impact marine ecosystems. While most MHW studies in the South China Sea (SCS) focus on the sea surface, subsurface characteristics remain less explored. This study uses high‐resolution (1/12°) ocean reanalysis data sets to assess MHW properties with depth in the SCS from 1993 to 2022. We find that MHW intensities are typically stronger at subsurface levels (30–150 m) than at the surface, with significant spatial variations. The vertical structures of MHW maximum and cumulative intensities peak between 70 and 100 m with 2.7°C and 63°C days, respectively; MHW annual days and duration increase gradually from 10 to 2,000 m with duration peaks at 2,000 m (∼60 days), four times longer than that at the surface. The SCS experienced two major periods of extensive El Niño‐related subsurface MHWs from 1997 to 2002 and 2008 to 2014, with MHWs reaching depths of 150 m and covering 70% of the upper 40 m. Strong El Niño events strengthen the western Pacific subtropical high, reducing summer monsoon winds, weakening coastal upwelling east of Vietnam, and increasing water temperatures. Regions of elevated eddy kinetic energy in the SCS suggest that significant mesoscale eddy activities are situated east of Vietnam. In addition, notable eddy heat transport was observed in the above region and west of the Luzon Strait in the upper 1,000 m. This may help to explain the high maximum and cumulative intensities of MHWs exceeding 100 m in the northern SCS.
Machine Learning‐Driven Spatiotemporal Analysis of Ozone Exposure and Health Risks in China
Authors: Ma Chendong , Song Jun , Ran Maohao , Wan Zhenglin , Guo Yike , Gao Meng 
Published: October 2024

AbstractAccurate and fine‐scaled prediction of ozone concentrations across space and time, as well as the assessment of associated human risks, is crucial for protecting public health and promoting environmental conservation. This paper introduces NetGBM, an innovative machine‐learning model designed to comprehensively model ozone levels across China's diverse topography and analyze the spatiotemporal distribution of ozone and exposure. Our model focuses on daily, weekly, and monthly predictions, achieving commendable coefficients of 0.83, 0.77, and 0.79, respectively. By constructing a gridded map of ozone and incorporating both land use and meteorological features into each grid, we achieved ozone prediction at a high spatiotemporal resolution, outperforming previous research in terms of performance and scale, particularly in regions with limited monitoring stations. The results can be further improved when applied to regional research using meteorological and ozone data from regional stations. Additionally, our research revealed that temperature is the most significant factor affecting ozone concentrations across China. In health risk assessment, we retrieved a high‐resolution spatial distribution of ozone‐attributed mortality for 5‐COD and daily ozone inhalation distributions during our study period. We concluded that ozone‐attributed mortality is predominantly caused by stroke and IHD, accounting for more than 70% of the total deaths in 2021, with the highest mortality rates in developed urban areas such as the NCP and the YRD. Our experiment demonstrated the potential of NetGBM in robustly modeling ozone across China with high spatiotemporal resolution and its applicability in measuring associated health risks.
Scenario‐Based Volcano Slope Stability Hazard Analysis: Case Study of Augustine Volcano, Alaska
Authors: Kanakiya Shreya 
Published: October 2024

AbstractVolcanoes worldwide have undergone cyclic destruction of their edifices, generating catastrophic volcanic debris avalanches. Augustine Volcano in Alaska, USA, has a history of debris avalanches, causing cyclic destruction of the edifice and cascading hazards. These collapses, together with eruption‐related changes in the edifice structure, change the slope stability hazard of the volcano over time. This study aims to develop a current view of the slope stability hazard at Augustine Volcano by (a) characterizing collapse‐prone source areas on the edifice under various scenarios typical of dynamic volcanic environments and (b) identifying the controlling factors that underlie the slope stability hazard. Scenario‐based slope stability assessment was conducted using a quasi‐3D limit equilibrium method to test for the effect of various factors that drive or resist failure, including topography, shallow edifice structure, strength of edifice‐forming materials, pore fluid pressure distribution, and local and regional seismicity. Results show that in all scenarios assessed, the slopes of Augustine Volcano are stable with a factor of safety (FOS) greater than 1. The FOS, however, decreases with decreasing strength of edifice‐forming materials, pore fluid pressurization, and earthquake loading. The location of the relatively less stable slope, changes to the southwestern flank when accounting for subsurface heterogeneities derived from geophysical observations. Subsurface heterogeneity is thus a key underlying factor, along with steep topography, in controlling where collapse‐prone source areas occur, and it should be accounted for in volcanic slope stability hazard assessments.
Droughts Amplify Soil Moisture Losses in Burned Forests of Southeastern Amazonia
Authors: Silveiro Antônio C. , Silvério Divino V. , Macedo Marcia N. , Coe Michael T. , Maracahipes Leandro , Uribe Maria , Maracahipes‐Santos Leonardo , Oliveira Paulo Tarso S. , Rattis Ludmila , Brando Paulo M. 
Published: October 2024

AbstractSoil moisture is a crucial variable mediating soil‐vegetation‐atmosphere water exchange. As climate and land use change, the increased frequency and intensity of extreme weather events and disturbances will likely alter feedbacks between ecosystem functions and soil moisture. In this study, we evaluated how extreme drought (2015/2016) and postfire vegetation regrowth affected the seasonality of soil water content (0–8 m depth) in a transitional forest in southeastern Amazonia. The experiment included three treatment plots: an unburned Control, an area burned every three years (B3yr), and an area burned annually (B1yr) between 2004 and 2010. We hypothesized that (a) soil moisture at B1yr and B3yr would be higher than the Control in the first years postfire due to lower transpiration rates, but differences between burned plots would decrease as postfire vegetation regrew; (b) during drought years, the soil water deficit in the dry season would be significantly greater in all plots as plants responded to greater evaporative demand; and (c) postfire recovery in the burned plots would cause an increase in evapotranspiration over time, especially in the topsoil. Contrary to the first expectation, the burned plots had lower volumetric water content than the Control plot. However, we found that droughts significantly reduced soil moisture in all plots compared to non‐drought years (15.6%), and this effect was amplified in the burned plots (19%). Our results indicate that, while compounding disturbances such as wildfires and extreme droughts alter forest dynamics, deep soil moisture is an essential water source for vegetation recovery.
Loss of body weight is dose-dependently associated with reductions in symptoms of hip osteoarthritis
Authors: Salis Zubeyir , Gallagher Ryan , Lawler Luke , Sainsbury Amanda 
Published: October 2024

Abstract
Background/objectives
While weight loss is recommended for managing hip osteoarthritis (OA), most evidence comes from knee OA studies, limiting its applicability to hip OA. This study addresses this gap by examining the effects of weight loss on hip OA symptoms.

Design and setting
A retrospective audit of routinely collected healthcare data from participants enrolled in the Osteoarthritis Healthy Weight for Life (OAHWFL) program, designed for individuals with knee or hip OA.

Participants
In total, 1714 adults with hip OA were selected from the OAHWFL program; 1408 completed the initial 18-week weight loss phase, while 306 did not complete it. After 18 weeks, participants transitioned to an indefinite weight maintenance phase.

Exposure
Percentage change in body weight from baseline at 18 weeks.

Outcomes
Changes in the five subscales of the Hip Disability and Osteoarthritis Outcome Score (HOOS) (Pain, Activity Limitations in Daily Living, Stiffness and Range of Motion, Sports and Recreation Function, and Hip-related Quality of Life) from baseline to 18 weeks.

Statistics
Linear regression, adjusted for sex and baseline values of age, weight, and respective HOOS scores, assessed the relationship between percentage weight change (analyzed as both a continuous variable and in categories: ≤2.5%, >2.5–5.0%, >5.0–7.5%, >7.5–10%, and >10% of baseline weight) and changes in all five HOOS subscales.

Results
At baseline, participants had a mean age of 65.14 years, 70% were female, and 78% were individuals with obesity (Body Mass Index ≥30 kg/m2). A statistically significant dose-response relationship was observed between weight loss and improvements in all HOOS subscales, with the greatest improvement in the Hip-related Quality of Life subscale (14.42 points, 31.14%) for >10% weight loss.

Conclusion
Our findings suggest that weight loss is associated with reduced symptoms of hip OA, supporting weight loss as an effective treatment strategy for hip OA.
Role of Planetary Health Diet in the association between genetic susceptibility to obesity and anthropometric measures in adults
Authors: Suikki Tiina , Maukonen Mirkka , Marjonen-Lindblad Heidi , Kaartinen Niina Erika , Härkänen Tommi , Jousilahti Pekka , Pajari Anne-Maria , Männistö Satu 
Published: October 2024

Abstract

Background/Objective
The roles of overall diet quality in linking genetic background with anthropometric measures are unclear, particularly regarding the recently developed Planetary Health Diet (PHD). This study aims to determine if the PHD mediates or moderates the relationship between genetic susceptibility to obesity and anthropometric measures.

Subjects/Methods
The study involved 2942 individuals from a Finnish population-based cohort (54% women, mean age 53 (SD ± 13) years). Habitual diet was assessed using a validated 130-item food frequency questionnaire, and the PHD Score (total score range 0–13 points) was adapted for Finnish food culture to evaluate diet quality. Genetic susceptibility to obesity was evaluated with a polygenic risk score (PRS) based on one million single nucleotide polymorphisms associated with body mass index (BMI). Baseline anthropometrics included weight, height, waist circumference (WC), and body fat percentage, with changes in these measures tracked over 7 years. A five-step multiple linear regression model and multivariable logistic regression with interaction terms were used to assess the mediating and moderating effects of the PHD. These analyses were also replicated in another Finnish cohort study (2 834 participants).

Results
PRS for BMI was positively associated with baseline BMI and changes in anthropometric measures, except waist circumference (p = 0.12). Significant associations were observed for baseline BMI and WC (p < 0.001), changes in BMI and WC (p = 0.01), and body fat percentage change (p = 0.05). However, the PHD (average score 3.8 points) did not mediate or moderate these relationships. These findings were consistent in the replication cohort.

Conclusion
Diet quality assessed with the PHD did not mediate or moderate the associations between genetic susceptibility to obesity and anthropometric measures. This lack of effect may be partly due to low adherence to the PHD and the older age of participants ( > 50 years) at baseline.
ERN GENTURIS guidelines on constitutional mismatch repair deficiency diagnosis, genetic counselling, surveillance, quality of life, and clinical management
Authors: Colas Chrystelle , Guerrini-Rousseau Léa , Suerink Manon , Gallon Richard , Kratz Christian P. , Ayuso Éloïse ,   ERN GENTURIS CMMRD Guideline Group, Andreiuolo Felipe , Azizi Amedeo A. , Beccaria Kevin , Burkhardt Birgit , Claret Beatrice , Dangouloff-ros Volodia , Drouet Youenn , Jongmans Marjolijn C. J. , van Kouwen Mariëtte , Ruiz-Ponte Clara , Svrcek Magali ,   Member of the European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS),   Member of the European consortium Care for CMMRD (C4CMMRD), Brugières Laurence , Wimmer Katharina 
Published: October 2024

AbstractConstitutional mismatch repair deficiency (CMMRD), first described 25 years ago, confers an extremely high and lifelong cancer risk, including haematologic, brain, and gastrointestinal tract malignancies, and is associated with several non-neoplastic features. Our understanding of this condition has improved and novel assays to assist CMMRD diagnosis have been developed. Surveillance protocols need adjustment taking into account recent observational prospective studies assessing their effectiveness. Response to immune checkpoint inhibitors and the effectiveness and toxicity of other treatments have been described. An update and merging of the different guidelines on diagnosis and clinical management of CMMRD into one comprehensive guideline was needed. Seventy-two expert members of the European Reference Network GENTURIS and/or the European care for CMMRD consortium and one patient representative developed recommendations for CMMRD diagnosis, genetic counselling, surveillance, quality of life, and clinical management based on a systematic literature search and comprehensive literature review and a modified Delphi process. Recommendations for the diagnosis of CMMRD provide testing criteria, propose strategies for CMMRD testing, and define CMMRD diagnostic criteria. Recommendations for surveillance cover each CMMRD-associated tumour type and contain information on starting age, frequency, and surveillance modality. Recommendations for clinical management cover cancer treatment, management of benign tumours or non-neoplastic features, and chemoprevention. Recommendations also address genetic counselling and quality of life. Based on existing guidelines and currently available data, we present 82 recommendations to improve and standardise the care of CMMRD patients in Europe. These recommendations are not meant to be prescriptive and may be adjusted based on individual decisions.
Heterozygous variants in the teashirt zinc finger homeobox 3 (TSHZ3) gene in human congenital anomalies of the kidney and urinary tract
Authors: Kesdiren Esra , Martens Helge , Brand Frank , Werfel Lina , Wedekind Lukas , Trowe Mark-Oliver , Schmitz Jessica , Hennies Imke , Geffers Robert , Gucev Zoran , Seeman Tomáš , Schmidt Sonja , Tasic Velibor , Fasano Laurent , Bräsen Jan H. , Kispert Andreas , Christians Anne , Haffner Dieter , Weber Ruthild G. 
Published: October 2024

AbstractAround 180 genes have been associated with congenital anomalies of the kidney and urinary tract (CAKUT) in mice, and represent promising novel candidate genes for human CAKUT. In whole-exome sequencing data of two siblings with genetically unresolved multicystic dysplastic kidneys (MCDK), prioritizing variants in murine CAKUT-associated genes yielded a rare variant in the teashirt zinc finger homeobox 3 (TSHZ3) gene. Therefore, the role of TSHZ3 in human CAKUT was assessed. Twelve CAKUT patients from 9/301 (3%) families carried five different rare heterozygous TSHZ3 missense variants predicted to be deleterious. CAKUT patients with versus without TSHZ3 variants were more likely to present with hydronephrosis, hydroureter, ureteropelvic junction obstruction, MCDK, and with genital anomalies, developmental delay, overlapping with the previously described phenotypes in Tshz3-mutant mice and patients with heterozygous 19q12-q13.11 deletions encompassing the TSHZ3 locus. Comparable with Tshz3-mutant mice, the smooth muscle layer was disorganized in the renal pelvis and thinner in the proximal ureter of the nephrectomy specimen of a TSHZ3 variant carrier compared to controls. TSHZ3 was expressed in the human fetal kidney, and strongly at embryonic day 11.5-14.5 in mesenchymal compartments of the murine ureter, kidney, and bladder. TSHZ3 variants in a 5′ region were more frequent in CAKUT patients than in gnomAD samples (p < 0.001). Mutant TSHZ3 harboring N-terminal variants showed significantly altered SOX9 and/or myocardin binding, possibly adversely affecting smooth muscle differentiation. Our results provide evidence that heterozygous TSHZ3 variants are associated with human CAKUT, particularly MCDK, hydronephrosis, and hydroureter, and, inconsistently, with specific extrarenal features, including genital anomalies.
Beliefs surrounding the use of inhaled asthma medication in The Gambia: a qualitative study of asthma patients and healthcare workers
Authors: Jayasooriya S. , Inoue M. , Allen H. , Bojang M. , Ceesay A. , Touray S. , Cooper R. , Mortimer K. , Balen J. 
Published: October 2024

AbstractAsthma-related mortality is high in low- and middle-income countries. Little is known about public perceptions of inhaled medicines. We conducted semi-structured interviews with asthma patients and healthcare workers at three secondary care facilities in The Gambia, between August and November 2022. Thematic analysis was used to interpret these data. A total of 20 patients and 15 healthcare workers were interviewed. Both groups noted limited access to inhalers was an issue resulting in continued use of oral medications. Some patients recognised the benefits of inhalers, yet beliefs that inhalers were dangerous were common. Reliance on oral short-acting beta agonists meant patients saw asthma as a recurrent acute condition resulting in an emphasis on hospital management with little awareness of inhaled preventative medicines. Increasing access to inhaled medicines has the potential to reduce costly avoidable admissions, but socio-cultural factors, in addition to medication supply, need addressing.
Thermal imaging and deep learning-based fit-checking for respiratory protection
Authors: Kim Hyunjin , Kim Tong Min , Choi Sae Won , Ko Taehoon 
Published: October 2024

AbstractThis study develops an artificial intelligence model to quickly and easily determine correct mask-wearing in real time using thermal videos that ascertained temperature changes caused by air trapped inside the mask. Five types of masks approved by the Korean Ministry of Food and Drug Safety were worn in four different ways across 50 participants, generating 5000 videos. The results showed that 3DCNN outperformed ConvLSTM in both binary and multi-classification for mask wearing methods, with the highest AUROC of 0.986 for multi-classification. Each mask type scored AUROC values > 0.9, with KF-AD being the best classified. This improved use of thermal imaging and deep learning for mask fit-checking could be useful in high-risk environments. It can be applied to various mask types, which enables easy generalizability and advantages in public and occupational health and healthcare system.