bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal morbidity after implementation of a postpartum hemorrhage protocol including use of misoprostol
Authors: Savirón‐Cornudella Ricardo , Esteban Luis M. , Laborda‐Gotor Ramiro , Rodríguez‐Solanilla Belén , De Mucio Bremen , Sanz Gerardo , Castán‐Mateo Sergio 
Published: October 2017

AbstractObjectiveTo compare maternal morbidity before and after implementation of a postpartum hemorrhage (PPH) protocol that included misoprostol.MethodsA retrospective analysis was performed using data from 34 631 deliveries recorded at a Spanish hospital between January 1, 2007, and December 31, 2014. The PPH protocol was implemented in 2009 and included use of misoprostol and the Bakri balloon.ResultsThe pre‐implementation and post‐implementation groups comprised 9394 and 25 237 women, respectively. Women in the pre‐implementation group tended to have lower hemoglobin levels than did those in the post‐implementation group: 811 (8.6%) versus 1349 (5.3%) for levels less than 90 g/L, and 272 (2.9%) versus 497 (2.0%) for levels less than 80 g/L (both P<0.001). Implementation of the PPH protocol was also associated with a decrease in the frequency of postpartum hysterectomies owing to uterine atony (0.11 cases per 1000 deliveries vs 0.53 cases per 1000 deliveries for the pre‐implementation group; P=0.063). Pregnancy length, maternal age, neonatal weight at delivery, multiple pregnancy, previous cesarean delivery, parity, operative vaginal delivery, induced labor, cesarean delivery, and not using the PPH protocol were found to predict postpartum anemia in the multivariate analysis (all P<0.001).ConclusionImplementation of the PPH protocol decreased rates of postpartum anemia and postpartum hysterectomy owing to uterine atony.
Aspartate‐β‐semialdeyhyde dehydrogenase as a potential therapeutic target of Mycobacterium tuberculosis H37Rv: Evidence from in silico elementary mode analysis of biological network model
Authors: Khan Saif , Somvanshi Pallavi , Bhardwaj Tulika , Mandal Raju K. , Dar Sajad A. , Wahid Mohd , Jawed Arshad , Lohani Mohtashim , Khan Mahvish , Areeshi Mohammed Y. , Haque Shafiul 
Published: October 2017

AbstractThe emergence of multi‐drug resistant strains and co‐occurrence of tuberculosis with HIV creates a major burden to the human health globally. Failure of primary antibacterial therapy necessitates the identification of new mycobacterial drugs. In this study, a comprehensive analysis involving bottom‐up systems biology approach was applied wherein we have identified potential therapeutic targets of Mycobacterium tuberculosis infections. Our study prioritized M. tuberculosis therapeutic targets (aspartate‐β‐semialdeyhde dehydrogenase [ASD], dihydrodipicolinate reductase and diaminopimelate decarboxylase) based on flux and elementary mode analysis using direct mathematical modeling of the relevant metabolic pathways. Molecular docking and simulation studies of the priority target (ie, ASD) revealed the therapeutic potential of the selected natural products (Huperzine A, Rosmarinic acid, and Curcumin) based ASD inhibitors. The study highlights the crucial role of systems biology in conjunction with molecular interaction (docking) for probing novel leads against an increasingly resistant pathogen, M. tuberculousis.
Simultaneous sequestration of nitrate and phosphate from wastewater using a tailor‐made bacterial consortium in biofilm bioreactor
Authors: Saha Amrita , Bhushan Shashi , Mukherjee Pallavi , Chanda Chaitali , Bhaumik Moumita , Ghosh Madhurima , Sharmin Jaweria , Datta Poulami , Banerjee Srimoyee , Barat Parthasarathi , Thakur Ashoke Ranjan , Gantayet Lalit Mohan , Mukherjee Indranil , Ray Chaudhuri Shaon 
Published: October 2017

AbstractBACKGROUNDMunicipal wastewater usually contains nitrate and phosphate as major contaminants, and if discharged untreated affects the health of the environment and human population. Currently available treatment technologies to treat municipal wastewater lose the essential growth nutrients ‘P’ and ‘N’ during treatment. This paper presents a strategy of simultaneous sequestration of nitrate and phosphate in biomass, by using a tailor‐made consortium in a biofilm reactor.RESULTSThe consortium comprising of three novel Bacillus strains in a fixed bed biofilm bioreactor maintained at ambient temperature showed reduction up to 94% of nitrate, 68% of phosphate, 93% of chemical oxygen demand, 97% of biochemical oxygen demand, 73% in total organic carbon while maintaining an effluent pH of 6.8 ± 0.02. Response surface methodology revealed maximum reduction at a flow rate of 1.97 L h‐1 with 306.04 mg L‐1 and 19.62 mg L‐1 of initial nitrate and phosphate concentrations respectively. The system was scaled up from 4.5 L to 220 L with the same retention time of 2 h and operated with consistent performance for over 212 days.CONCLUSIONThe treated wastewater met the criterion for reuse as non‐potable water for applications like irrigation and aquaculture, hence making it the fastest microbial process for simultaneous nitrate and phosphate removal from wastewater. © 2017 Society of Chemical Industry
The anterior process of the malleus in extant Lagomorpha (Mammalia)
Authors: Maier Wolfgang , Tröscher Adrian , Ruf Irina 
Published: October 2017

AbstractThe anterior anchoring of the malleus of 30 extant species of Lagomorpha (rabbits, hares, pikas) has been studied on the basis of histological serial sections and µCT‐scans. It is shown that former studies of Oryctolagus, Lepus, and Ochotona are incomplete, because the rostral part of the processus anterior of the malleus is always lacking due to damage of this extremely delicate structure. Our study shows that in perinatal stages of Leporidae the praearticulare develops a prominent processus internus that fits into a groove at the ventral side of the tegmen tympani; this “tongue and groove”‐arrangement may act as a hinge. In adult stages, the rostral end of the praearticulare fuses synostotically with the medial process of the ectotympanic. Torsional strain produced by rotation around the axis of the middle ear ossicles at sound transmission must, therefore, be experienced by the extremely thin but highly elastic bony pedicle of the processus internus praearticularis. The free ending processus anterior of a late fetal Ochotona shows a short processus internus praearticularis, which does not articulate with the tegmen tympani. During postnatal development the middle ear of Ochotona becomes considerably remodelled: not only does excessive pneumatization of the tegmen tympani and tympanic cavity wall occur, but the short processus anterior is fused synostotically to a bone trabecula of the tegmen tympani meshwork. The thin and elastic bone bridges are not equivalent in Leporidae and Ochotonidae, that is, they must have evolved convergently. Fleischer's classification with Oryctolagus possessing a “freely mobile type” of middle ear ossicles cannot be supported by our observations. The same holds true for Ochotona, which does not represent a “freely mobile type” either. Thus, we suggest for the lagomorph middle ear ossicles a new category: the “bone elasticity type.”
Study on the interaction between cannabinol and DNA using acridine orange as a fluorescence probe
Authors: Tian Zhengshan , Wang Zechun , Han Xinxin , Wang Ning , Wang Ruiyong 
Published: October 2017

AbstractThe interaction between cannabinol (CBN) and herring‐sperm deoxyribonucleic acid was investigated by using acridine orange as a fluorescence probe in this work. UV‐Vis spectroscopy, fluorescence spectroscopy, and DNA melting techniques were used. The fluorescence of DNA acridine orange was quenched by CBN. The results indicated that CBN can bind to DNA. The binding constant for the CBN and herring‐sperm deoxyribonucleic acid was obtained at 3 temperatures, respectively. Results of molecular docking corroborated the experimental results obtained from spectroscopic investigations. The influence of ionic strength on the fluorescence properties was also investigated. The thermodynamic results indicated that hydrophobic interaction played a major role in the binding between CBN and DNA.
The influence of community factors on the engagement of residents in place promotion: Empirical evidence from an Italian heritage site
Authors: Vollero Agostino , Conte Francesca , Bottoni Gianmaria , Siano Alfonso 
Published: October 2017

AbstractThe engagement of community residents in place promotion is increasingly recognized as desirable for ensuring effective and reliable communication with tourists. The study investigated the effects of community factors on residents' engagement in the promotion of an Italian heritage site. Community commitment, environmental attitudes, and perceptions of the effectiveness of existing place marketing communications were found to be decisive in influencing residents' engagement in the promotion of the Amalfi Coast. The paper helps to shed light on collaboration in place promotion, thus enriching the debate on the ambassadorship role of residents and suggesting useful insights for policy makers/destination management organizations.
The safety and efficacy of powered intracapsular tonsillectomy in children: A meta‐analysis
Authors: Lee Ho Seok , Yoon Ho Young , Jin Ho Joon , Hwang Se Hwan 
Published: October 2017

ObjectivesWe performed a systemic review and meta‐analysis regarding the postoperative pain, perioperative, and postoperative morbidity of powered intracapsular tonsillectomy and adenoidectomy (PITA) using a microdebrider as a method of tonsillectomy.Data SourcesFive databases (PubMed, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials) in their entirety through March 2017.Review MethodsWe included studies in which there was a comparison between groups of patients who underwent PITA (PITA group) and those who had extracapsular tonsillectomy (control group). Articles assessing effects of PITA in the pediatric patient were systemically and independently reviewed by two researchers. The outcomes of interest were intraoperative morbidity (operative time and bleeding), postoperative morbidity (postoperative pain, recovery time, tonsil regrowth, and postoperative bleeding rate), and improvement of sleep breath disorder (apnea‐hypopnea index [AHI] and symptomatic scores).ResultsPITA did not significantly increase operative time or intraoperative blood loss. With PITA, there was significantly decreased postoperative pain, amount of analgesia, time to resumption of normal diet and activity, and incidence of postoperative admissions (due to dehydration or postoperative bleeding control) compared to those of the control group. In contrast, the incidence of postoperative tonsil regrowth was statistically higher in the PITA group than in the control group. The PITA improved AHI and obstructive sleep apnea 18‐item questionnaire scores significantly, which were similar with the control group.ConclusionsWith regard to intraoperative morbidity and postoperative morbidity, PITA is a safe procedure. However, there are high levels of heterogeneity with regard to several measured parameters. Therefore, further large, well‐designed trials are required to substantiate our findings. Laryngoscope, 128:732–744, 2018
Recent progress of retroauricular robotic thyroidectomy with the new surgical robotic system
Authors: Byeon Hyung Kwon , Holsinger F. Christopher , Duvvuri Umamaheswar , Kim Da Hee , Park Jae Hong , Chang Estelle , Kim Se‐Heon , Koh Yoon Woo 
Published: October 2017

ObjectivePreviously, we have reported the feasibility of retroauricular (RA) robotic thyroidectomy. Despite its promising surgical outcomes, there were certain intrinsic mechanical limitations inherent to the da Vinci Si System (Intuitive Surgical, Sunnyvale, California, U.S.A.). Since the advent of an upgraded model, the Xi System (Intuitive Surgical), we have actively incorporated the new model into performing RA thyroidectomy. Here, we intend to verify the feasibility of RA robotic thyroidectomy using the new da Vinci Xi System (Intuitive Surgical) with comparison of the former Si‐applied surgery (Intuitive Surgical).Study DesignComparative analysis.MethodsThere were total 165 consecutive patients who received RA robotic thyroidectomy from January 2013 to February 2016. The patients were divided into two groups: Si group (n = 125) and Xi group (n = 40). Perioperative and treatment outcomes were compared and analyzed.ResultsCompared with the previous system, new da Vinci Xi system (Intuitive Surgical) enabled insertion of an extra third robotic instrumental arm. Unlike the previous robotic surgical technique, the robotic dissection could be initiated immediately after the establishment of working space and the resulting total operation time could be significantly decreased. There was no difference in the surgical completeness, as confirmed by postoperative thyroglobulin levels. Additionally, flexed EndoWrist (Intuitive Surgical) instruments equipped with the Erbe (Erbe USA Inc., Marietta, Georgia, U.S.A.) system could be mounted, which further facilitated the operation. There were no significant differences in postoperative complications between the two groups.ConclusionThe RA robotic thyroidectomy with the new Xi System (Intuitive Surgical) can greatly facilitate the robotic surgery with comparable or improved surgical outcomes. Its application is expected to open up a new era of robotic neck surgery.Level of Evidence4. Laryngoscope, 128:1730–1737, 2018
Synthesis of Multifunctionalized Graft‐Type Polyolefin‐Based Elastomers with a High Utility Temperature
Authors: Ying Wu Bin , Lee Min Woo , Yang Hee Sang , Moon Da Som , Ko Na Yeong , Lee Bumjae , Zhu Jin , Zhang Ruoyu , Lee Kyung Jin 
Published: October 2017

AbstractA novel polyolefin‐based elastomer of polyolefin‐graft‐poly(t‐butylstyrene) is synthesized from styrene moieties via graft‐from anionic living polymerization. The afforded elastomer comprises a soft poly(ethylene‐t‐1‐hexene‐t‐divinylbenzene) segment and a hard poly(t‐butylstyrene) [P(t‐BS)] segment. The polymerization proceeds via complete lithiation of the pendent styrene groups (polyolefin elastomer) and subsequent graft anionic polymerization of 4‐tert‐butylstyrene (2000–10 000 g mol−1). The graft‐from living anionic polymerization controls the grafting size with excellent efficiency by increasing the monomer concentration. To introduce functional groups into the polymer chain‐end, vinyl isoprene units are introduced into the polyolefin‐graft‐poly(t‐butylstyrene) anion to form polyolefin‐graft‐[poly(t‐butylstyrene)‐block‐polyisoprene] via living block copolymerization. Subsequent graft chain‐end multicarboxyl functionalization via thiol‐ene “click” reactions introduces carboxyl groups into the [P(t‐BS)] graft chain‐end. The water contact angle of this multicarboxyl functionalized product exhibits a sharper decrement, which affects its hydrophilicity significantly. This process produces a novel, well‐defined functionalized graft‐type polyolefin‐based elastomer with a high utility temperature and excellent mechanical properties.
Falls in Parkinson's disease: A complex and evolving picture
Authors: Fasano Alfonso , Canning Colleen G. , Hausdorff Jeffrey M. , Lord Sue , Rochester Lynn 
Published: October 2017

ABSTRACTFalls are a major determinant of poor quality of life, immobilization, and reduced life expectancy in people affected by Parkinson's disease (PD) and in older adults more generally. Although many questions remain, recent research has advanced the understanding of this complex problem. The goal of this review is to condense new knowledge of falls in PD from prodromal to advanced disease, taking into account risk factors, assessment, and classification as well as treatment. The fundamental steps of clinical and research‐based approaches to falls are described, namely, the identification of fall risk factors, clinical and instrumental methods to evaluate and classify fall risk, and the latest evidence to reduce or delay falls in PD. We summarize recent developments, the direction in which the field should be heading, and what can be recommended at this stage. We also provide a practical algorithm for clinicians.© 2017 International Parkinson and Movement Disorder Society
The American Society of Pediatric Hematology/Oncology workforce assessment: Part 1—Current state of the workforce
Authors: Hord Jeffrey , Shah Mona , Badawy Sherif M. , Matthews Dana , Hilden Joanne , Wayne Alan S. , Salsberg Edward , Leavey Patrick S. ,   on behalf of the American Society of Pediatric Hematology/Oncology Workforce Advisory Taskforce
Published: October 2017

AbstractThe American Society of Pediatric Hematology/Oncology (ASPHO) recognized recent changes in medical practice and the potential impact on pediatric hematology–oncology (PHO) workforce. ASPHO surveyed society members and PHO Division Directors between 2010 and 2016 and studied PHO workforce data collected by the American Board of Pediatrics and the American Medical Association to characterize the current state of the PHO workforce. The analysis of this information has led to a comprehensive description of PHO physicians, professional activities, and workplace. It is important to continue to collect data to identify changes in composition and needs of the PHO workforce.
Robust control of a family of uncertain nonminimum‐phase systems via continuous‐time and sampled‐data output feedback
Authors: Lin Wei , Wei Wei 
Published: October 2017

SummaryThe problem of global robust stabilization is studied by both continuous‐time and sampled‐data output feedback for a family of nonminimum‐phase nonlinear systems with uncertainty. The uncertain nonlinear system considered in this paper has an interconnect structure consisting of a driving system and a possibly unstable zero dynamics with uncertainty, ie, the uncertain driven system. Under a linear growth condition on the uncertain zero dynamics and a Lipschitz condition on the driving system, we show that it is possible to globally robustly stabilize the family of uncertain nonminimum‐phase systems by a single continuous‐time or a sampled‐data output feedback controller. The sampled‐data output feedback controller is designed by using the emulated versions of a continuous‐time observer and a state feedback controller, ie, by holding the input/output signals constant over each sampling interval. The design of either continuous‐time or sampled‐data output compensator uses only the information of the nominal system of the uncertain controlled plant. In the case of sampled‐data control, global robust stability of the hybrid closed‐loop system with uncertainty is established by means of a feedback domination method together with the robustness of the nominal closed‐loop system if the sampling time is small enough.
Gold Nanoparticles from Vegetable Extracts Using Different Plants from the Market: A Study on Stability, Shape and Toxicity
Authors: Clemente Ilaria , Ristori Sandra , Pierucci Federica , Muniz‐Miranda Maurizio , Salvatici Maria Cristina , Giordano Cristiana , Meacci Elisabetta , Feis Alessandro , Gonnelli Cristina 
Published: October 2017

AbstractThe use of nanoparticles for many advanced applications (drug‐delivery, biosensors, catalysts etc.) involves their large scale production. This engenders the need of synthetic methods and reactants which are sustainable as well as safe. Natural products allow to prepare nanoparticles via eco‐friendly processes, which is especially true for reducing/capping agents obtained from agricultural by‐products. Here, we prepared gold nanoparticles (AuNPs) in high yields by using extracts from the leaves of marketable plants and by following different synthetic routes (i. e. one‐ or two‐steps). The size and morphology of the obtained AuNPs were determined by Transmission Electron Microscopy (TEM), while surface coverage with different chemical species was investigated by surface‐enhanced Raman scattering (SERS). In vitro experiments on bone‐marrow mesenchymal stromal cells (MSCs) were used to study the effect on cell viability, as a first step toward toxicity assessment. This work allowed to select the nanoparticles with highest SERS activity at infrared excitation wavelength, in view of their possible use as shelf products.
Deep Axial Inclusion of Two Aromatic Molecules by Dimethyl‐β‐Cyclodextrin and β‐Cyclodextrin
Authors: Kobayashi Yayoi , Hoshi Tomonori , Yamamoto Satoshi , Kimura Mutsumi , Kobayashi Nagao 
Published: October 2017

AbstractElectronic absorption, induced circular dichroism, and 1H NMR spectroscopies, together with molecular orbital calculations, have indicated the attainment of a deep axial inclusion of two aromatic molecules by β‐cyclodextrin and dimethyl‐β‐cyclodextrin, by selecting quinhydrone (1:1 compound consisting of benzoquinone and hydroquinone) as a guest molecule.
Calcium Bismuthate Nanoparticulates with Orthorhombic and Rhombohedral Crystalline Lattices: Effects of Composition and Structure on Photoactivity
Authors: Shtarev Dmitry S. , Ryabchuk Vladimir K. , Makarevich Konstantin S. , Shtareva Anna V. , Blokh Artem I. , Astapov Ivan A. , Serpone Nick 
Published: October 2017

AbstractCalcium bismuthate nanoparticles with orthorhombic and rhombohedral crystal lattices were synthesized and characterized by various techniques. The syntheses caused the formation of oxygen and cationic vacancies in bismuth‐deficient samples. Heat treatment of samples with anionic vacancies led to thermal annealing of oxygen vacancies in ambient air; the annealing process was reversible. Oxygen vacancies in Bi‐deficient CaBi6O10 governed the optical absorption beyond the fundamental absorption edge at E(hν) < Ebg ≈ 2.5 eV. Bandgap energies of the bismuthates with orthorhombic and rhombohedral lattices were 2.51 eV prior to annealing and 2.47 eV after annealing at 350 °C. The trend in photoactivity toward the degradation of methylene blue dye under visible light showed that the photoactivity of the orthorhombic samples (1‐3) increased with a decrease in the [Ca]:[Bi] ratio (1.0:6.3 to 1.0:4.3); the sample with lowest ratio (1.0:4.3) displayed highest photoactivity. By contrast, the rhombohedral samples (4‐6) showed increased photoactivity with increase in the number of Bi atoms; sample with highest ratio (1.0:6.3) displayed highest photoactivity.
The effect of sodium bicarbonate and validation of beckman coulterAU680 analyzers for measuring total carbon dioxide (TCO2) concentrations in horse serum
Authors: Dirikolu Levent , Waller Pamela , Waguespack Mona Landry , Andrews Frank Michael , Keowen Michael Layne , Gaunt Stephen David 
Published: October 2017

AbstractThis study evaluated the usage of Beckman CoulterAU680 analyzers for measurement ofTCO2in horse serum, and the effect of sodium bicarbonate administrations on serumTCO2levels in resting horses. Treatment of horses with sodium bicarbonate did not result in any adverse events. MeanTCO2concentration was significantly higher from 1 to 8 h in the sodium bicarbonate‐treated horses compared to the untreated controls. Within an hour, administration of sodium bicarbonate increased theTCO2level from 31.5 ± −2.5 (SD) to 34.0 ± 2.65 (SD) mmol/L and at 2–8 h post‐administration, theTCO2level was above the 36 mmol/L cut‐off level. In all quality control analysis of Australian standard by Beckman CoulterAU680 analyzer, the instrument slightly over estimated theTCO2level but the values were in close agreement with meanTCO2level being 38.03 with ± 0.87 mmol/L (SD). Expanded uncertainty was calculated using different levels of confidence interval. Based on 99.5% confidence interval using 0.805% expanded uncertainty using mean measured concentration of 38.05 mmol/L, it was estimated that any race samplesTCO2level higher than 38.5 mmol/L will be indicative of sodium bicarbonate administration using Beckman CoulterAU680 analyzer in Louisiana.