bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel approach to ductal spasm during percutaneous device occlusion of patent ductus arteriosus
Authors: De Decker Rik , Comitis George , Thomas Jenny , van der Merwe Elmarie , Lawrenson John 
Published: December 2015

AbstractDuctal spasm is a rare yet important complication of device occlusions of patent ductus arteriosus. Spasm may result in failure of the procedure, under-sizing of the device, or embolisation of the implanted device as the spasm resolves after the procedure. We describe a novel protocol that rapidly and completely reversed the spasm in eight prematurely born infants who experienced ductal spasm during cardiac catheterisations for patent ductus arteriosus occlusion.In total, eight infants born between 25 and 34 weeks of gestation presented for transcatheter patent ductus arteriosus occlusion between 13 and 87 months of age. All eight patients experienced ductal spasm either immediately before, during, or soon after induction of anaesthesia or only after entering the ductus arteriosus with a catheter. After detection of the spasm, the anaesthetist, in each case, changed the mode of anaesthesia from inhaled sevoflurane to total intravenous anaesthesia with propofol, reduced the inhaled oxygen fraction to 21%, and initiated a continuous intravenous infusion of prostaglandin E1.The first two steps (total intravenous anaesthesia and FiO2 0.21) resulted in only partial relaxation of the spasm. Complete relaxation was attained after intravenous prostaglandin E1 infusions of only 10–15 minutes’ duration. While maintaining this protocol, six ducti were successfully occluded and two were considered to be unsuitable for device occlusion and were referred for surgery.Ductal spasm during transcatheter occlusion may be reliably resolved and the procedure safely completed by a simple anaesthetic protocol, including the continuous infusion of intravenous prostaglandin E1.
Testing the Identification/Production Hypothesis of Implicit Memory in Schizophrenia: The Role of Response Competition
Authors: Marques Valéria R.S. , Spataro Pietro , Cestari Vincenzo , Sciarretta Antonio , Rossi-Arnaud Clelia 
Published: December 2015

AbstractObjectives:Previous evidence indicates that patients with schizophrenia exhibit reduced repetition priming in production tasks (in which each response cue engenders a competition between alternative responses), but not in identification tasks (in which each response cue allows a unique response). However, cross-task comparisons may lead to inappropriate conclusions, because implicit tests vary on several dimensions in addition to the critical dimension of response competition. The present study sought to isolate the role of response competition, by varying the number of solutions in the context of the same implicit tasks.Methods:Two experiments investigated the performance of patients with schizophrenia and healthy controls in the high-competition and low-competition versions of word-stem completion (Exp.1) and verb generation (Exp.2).Results:Response competition affected both the proportions of stems completed (higher to few-solution than to many-solution stems) and the reaction times of verb generation (slower to nouns having no dominant verb associates than to nouns having one dominant verb associate). Patients with schizophrenia showed significant (non-zero) priming in both experiments: crucially, the magnitude of this facilitation was equivalent to that observed in healthy controls and was not reduced in the high-competition versions of the two tasks.Conclusions:These findings suggest that implicit memory is spared in schizophrenia, irrespective of the degree of response competition during the retrieval phase; in addition, they add to the ongoing debate regarding the validity of the identification/production hypothesis of repetition priming. (JINS, 2015,21, 314–321)
FROM STENIUS’ CONSISTENCY PROOF TO SCHÜTTE’S CUT ELIMINATION FOR ω-ARITHMETIC
Authors: SIDERS ANNIKA 
Published: December 2015

AbstractThe book Das Interpretationsproblem der Formalisierten Zahlentheorie und ihre Formale Widerspruchsfreiheit by Erik Stenius published in 1952 contains a consistency proof for infinite ω-arithmetic based on a semantical interpretation. Despite the proof’s reference to semantics the truth definition is in fact equivalent to a syntactical derivability or reduction condition. Based on this reduction condition Stenius proves that the complexity of formulas in a derivation can be limited by the complexity of the conclusion. This independent result can also be proved by cut elimination for ω-arithmetic which was done by Schütte in 1951.In this paper we interpret the syntactic reduction in Stenius’ work as a method for cut elimination based on invertibility of the logical rules. Through this interpretation the constructivity of Stenius’ proof becomes apparent. This improvement was explicitly requested from Stenius by Paul Bernays in private correspondence (In a letter from Bernays begun on the 19th of September 1952 (Stenius & Bernays, 1951–75)). Bernays, who took a deep interest in Stenius’ manuscript, applied the described method in a proof Herbrand’s theorem. In this paper we prove Herbrand’s theorem, as an application of Stenius’ work, based on lecture notes of Bernays (Bernays, 1961). The main result completely resolves Bernays’ suggestions for improvement by eliminating references to Stenius’ semantics and by showing the constructive nature of the proof. A comparison with Schütte’s cut elimination proof shows how Stenius’ simplification of the reduction of universal cut formulas, which in Schütte’s proof requires duplication and repositioning of the cuts, shifts the problematic case of reduction to implications.
Talc-dominated seafloor deposits reveal a new class of hydrothermal system
Authors: Hodgkinson Matthew R. S. , Webber Alexander P. , Roberts Stephen , Mills Rachel A. , Connelly Douglas P. , Murton Bramley J. 
Published: December 2015

AbstractThe Von Damm Vent Field (VDVF) is located on the flanks of the Mid-Cayman Spreading Centre, 13 km west of the axial rift, within a gabbro and peridotite basement. Unlike any other active vent field, hydrothermal precipitates at the VDVF comprise 85–90% by volume of the magnesium silicate mineral, talc. Hydrothermal fluids vent from a 3-m high, 1-m diameter chimney and other orifices at up to 215 °C with low metal concentrations, intermediate pH (5.8) and high concentrations (667 mmol kg−1) of chloride relative to seawater. Here we show that the VDVF vent fluid is generated by interaction of seawater with a mafic and ultramafic basement which precipitates talc on mixing with seawater. The heat flux at the VDVF is measured at 487±101 MW, comparable to the most powerful magma-driven hydrothermal systems known, and may represent a significant mode of off-axis oceanic crustal cooling not previously recognized or accounted for in global models.
Efficient chemo-enzymatic gluten detoxification: reducing toxic epitopes for celiac patients improving functional properties
Authors: Ribeiro Miguel , Nunes Fernando M. , Guedes Sofia , Domingues Pedro , Silva Amélia M. , Carrillo Jose Maria , Rodriguez-Quijano Marta , Branlard Gérard , Igrejas Gilberto 
Published: December 2015

AbstractProtein engineering of gluten, the exogenous effector in celiac disease, seeking its detoxification by selective chemical modification of toxic epitopes is a very attractive strategy and promising technology when compared to pharmacological treatment or genetic engineering of wheat. Here we present a simple and efficient chemo-enzymatic methodology that decreases celiac disease toxic epitopes of gluten proteins improving its technological value through microbial transglutaminase-mediated transamidation of glutamine with n-butylamine under reducing conditions. First, we found that using low concentrations of amine-nucleophile under non-reducing conditions, the decrease in toxic epitopes is mainly due to transglutaminase-mediated cross-linking. Second, using high amine nucleophile concentrations protein cross-linking is substantially reduced. Third, reducing conditions increase 7-fold the transamidation reaction further decreasing toxic epitopes amount. Fourth, using n-butylamine improves gluten hydrophobicity that strengthens the gluten network. These results open the possibility of tailoring gluten for producing hypoallergenic flours while still taking advantage of the unique viscoelastic properties of gluten.
Simultaneously precise frequency transfer and time synchronization using feed-forward compensation technique via 120 km fiber link
Authors: Chen Xing , Lu Jinlong , Cui Yifan , Zhang Jian , Lu Xing , Tian Xusheng , Ci Cheng , Liu Bo , Wu Hong , Tang Tingsong , Shi Kebin , Zhang Zhigang 
Published: December 2015

AbstractPrecision time synchronization between two remote sites is desired in many applications such as global positioning satellite systems, long-baseline interferometry, coherent radar detection and fundamental physics constant measurements. The recently developed frequency dissemination technologies based on optical fiber link have improved the transfer instability to the level of 10−19/day at remote location. Therefore it is possible to keep clock oscillation at remote locations continuously corrected, or to reproduce a “virtual” clock on the remote location. However the initial alignment and the correction of 1 pps timing signal from time to time are still required, besides the highly stabilized clock frequency transfer between distant locations. Here we demonstrate a time synchronization based on an ultra-stable frequency transfer system via 120-km commercial fiber link by transferring an optical frequency comb. Both the phase noise compensation in frequency dissemination and temporal basis alignment in time synchronization were implemented by a feed-forward digital compensation (FFDC) technique. The fractional frequency instability was measured to be 6.18 × 10−20 at 2000 s. The timing deviation of time synchronization was measured to be 0.6 ps in 1500 s. This technique also can be applied in multi-node fiber network topology.
An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility
Authors: Bartok Adam , Fehér Krisztina , Bodor Andrea , Rákosi Kinga , Tóth Gábor K. , Kövér Katalin E. , Panyi Gyorgy , Varga Zoltan 
Published: December 2015

AbstractThe voltage-gated Kv1.3 K+ channel plays a key role in the activation of T lymphocytes. Kv1.3 blockers selectively suppress immune responses mediated by effector memory T cells, which indicates the great potential of selective Kv1.3 inhibitors in the therapy of certain autoimmune diseases. Anuroctoxin (AnTx), a 35-amino-acid scorpion toxin is a high affinity blocker of Kv1.3, but also blocks Kv1.2 with similar potency. We designed and produced three AnTx variants: ([F32T]-AnTx, [N17A]-AnTx, [N17A/F32T]-AnTx) using solid-phase synthesis with the goal of improving the selectivity of the toxin for Kv1.3 over Kv1.2 while keeping the high affinity for Kv1.3. We used the patch-clamp technique to determine the blocking potency of the synthetic toxins on hKv1.3, mKv1.1, hKv1.2 and hKCa3.1 channels. Of the three variants [N17A/F32T]-AnTx maintained the high affinity of the natural peptide for Kv1.3 but became more than 16000-fold selective over Kv1.2. NMR data and molecular dynamics simulations suggest that the more rigid structure with restricted conformational space of the double substituted toxin compared to the flexible wild-type one is an important determinant of toxin selectivity. Our results provide the foundation for the possibility of the production and future therapeutic application of additional, even more selective toxins targeting various ion channels.
A Smart Colorful Supercapacitor with One Dimensional Photonic Crystals
Authors: Liu Cihui , Liu Xing , Xuan Hongyun , Ren Jiaoyu , Ge Liqin 
Published: December 2015

AbstractTo meet the pressing demands for portable and flexible equipment in contemporary society, developing flexible, lightweight and sustainable supercapacitor systems with large power densities, long cycle life and ease of strongly required. However, estimating the state-of-charge of existing supercapacitors is difficult and thus their service life is limited. In this study, we fabricate a flexible color indicative supercapacitor device with mesoporous polyaniline (mPANI)/Poly(N-Isopropyl acrylamide-Graphene Oxide-Acrylic Acid) (P(NiPPAm-GO-AA)) one dimensional photonic crystals (1DPCs) as the electrode material through a low-cost, eco-friendly and scalable fabrication process. We found that the state-of-charge could be monitored by the structural color oscillation due to the change in the photonic band gap position of the 1DPCs. The flexible 1DPCs supercapacitor is thin at 3 mm and exhibits good specific capacitance of 22.6 F g−1 with retention of 91.1% after 3,000 cycles. This study shows the application of the 1DPCs supercapacitor as a visual ultrathin power source. The technology may find many applications in future wearable electronics.
Independently tunable dual-band perfect absorber based on graphene at mid-infrared frequencies
Authors: Zhang Yuping , Li Tongtong , Chen Qi , Zhang Huiyun , O’Hara John F. , Abele Ethan , Taylor Antoinette J. , Chen Hou-Tong , Azad Abul K. 
Published: December 2015

AbstractWe design a dual-band absorber formed by combining two cross-shaped metallic resonators of different sizes within a super-unit-cell arranged in mirror symmetry. Simulations indicate that absorption efficiencies greater than 99% can be achieved at two different frequencies under normal incidence. We employ a design scheme with graphene integration, which allows independent tuning of individual absorption frequencies by electrostatically changing the Fermi energy of the graphene layer. High absorbance is maintained over a wide incident angle range up to 50 degrees for both TE and TM polarizations. It thus enables a promising way to design electrically tunable absorbers, which may contribute toward the realization of frequency selective detectors for sensing applications.
Disparate metabolic response to fructose feeding between different mouse strains
Authors: Montgomery M. K. , Fiveash C. E. , Braude J. P. , Osborne B. , Brown S. H. J. , Mitchell T. W. , Turner N. 
Published: December 2015

AbstractDiets enriched in fructose (FR) increase lipogenesis in the liver, leading to hepatic lipid accumulation and the development of insulin resistance. Previously, we have shown that in contrast to other mouse strains, BALB/c mice are resistant to high fat diet-induced metabolic deterioration, potentially due to a lack of ectopic lipid accumulation in the liver. In this study we have compared the metabolic response of BALB/c and C57BL/6 (BL6) mice to a fructose-enriched diet. Both strains of mice increased adiposity in response to FR-feeding, while only BL6 mice displayed elevated hepatic triglyceride (TAG) accumulation and glucose intolerance. The lack of hepatic TAG accumulation in BALB/c mice appeared to be linked to an altered balance between lipogenic and lipolytic pathways, while the protection from fructose-induced glucose intolerance in this strain was likely related to low levels of ER stress, a slight elevation in insulin levels and an altered profile of diacylglycerol species in the liver. Collectively these findings highlight the multifactorial nature of metabolic defects that develop in response to changes in the intake of specific nutrients and the divergent response of different mouse strains to dietary challenges.
Splitting of standing spin-wave modes in circular submicron ferromagnetic dot under axial symmetry violation
Authors: Bunyaev S. A. , Golub V. O. , Salyuk O. Yu. , Tartakovskaya E. V. , Santos N. M. , Timopheev A. A. , Sobolev N. A. , Serga A. A. , Chumak A. V. , Hillebrands B. , Kakazei G. N. 
Published: December 2015

AbstractThe spin wave dynamics in patterned magnetic nanostructures is under intensive study during the last two decades. On the one hand, this interest is generated by new physics that can be explored in such structures. On the other hand, with the development of nanolithography, patterned nanoelements and their arrays can be used in many practical applications (magnetic recording systems both as media and read-write heads, magnetic random access memory and spin-torque oscillators just to name a few). In the present work the evolution of spin wave spectra of an array of non-interacting Permalloy submicron circular dots for the case of magnetic field deviation from the normal to the array plane have been studied by ferromagnetic resonance technique. It is shown that such symmetry violation leads to a splitting of spin-wave modes and that the number of the split peaks depends on the mode number. A quantitative description of the observed spectra is given using a perturbation theory for small angles of field inclination from the symmetry direction. The obtained results give possibility to predict transformation of spin wave spectra depending on direction of the external magnetic field that can be important for spintronic and nanomagnetic applications.
Directly interrogating single quantum dot labelled UvrA2 molecules on DNA tightropes using an optically trapped nanoprobe
Authors: Simons Michelle , Pollard Mark R. , Hughes Craig D. , Ward Andrew D. , Van Houten Bennett , Towrie Mike , Botchway Stan W. , Parker Anthony W. , Kad Neil M. 
Published: December 2015

AbstractIn this study we describe a new methodology to physically probe individual complexes formed between proteins and DNA. By combining nanoscale, high speed physical force measurement with sensitive fluorescence imaging we investigate the complex formed between the prokaryotic DNA repair protein UvrA2 and DNA. This approach uses a triangular, optically-trapped “nanoprobe” with a nanometer scale tip protruding from one vertex. By scanning this tip along a single DNA strand suspended between surface-bound micron-scale beads, quantum-dot tagged UvrA2 molecules bound to these ‘”DNA tightropes” can be mechanically interrogated. Encounters with UvrA2 led to deflections of the whole nanoprobe structure, which were converted to resistive force. A force histogram from all 144 detected interactions generated a bimodal distribution centered on 2.6 and 8.1 pN, possibly reflecting the asymmetry of UvrA2’s binding to DNA. These observations successfully demonstrate the use of a highly controllable purpose-designed and built synthetic nanoprobe combined with fluorescence imaging to study protein-DNA interactions at the single molecule level.
Spoof surface plasmon based planar antennas for the realization of Terahertz hotspots
Authors: Zhang Yusheng , Han Zhanghua 
Published: December 2015

AbstractNovel spoof surface plasmon based terahertz (THz) antennas are realized using a few number of rectangular grooves perforated in ultrathin metal stripes and the properties of them, including both scattering cross sections and field enhancement, are numerically analyzed. The dependence of these properties on the incident angle and groove number is discussed and the results show that sharp resonances in scattering cross section spectra associated with strong local field enhancement can be achieved. These resonances are due to the formation of Fabry-Perot resonances of the spoof surface plasmon mode and it is found that the order of resonance exhibiting strongest field enhancements is found to coincide with the number of grooves at normal incidence, due to hybridization of the antenna resonance with the individual groove resonance. The terahertz hotspots within the grooves at resonances due to the local field enhancement may open up new possibilities for the investigation of terahertz-matter interactions and boost a variety of THz applications including novel sensing and THz detections. The planar stripe antennas with sharper resonances than dipolar-like resonances, together with their ease of fabrication may also promise new design methodology for metamaterials.
Vitamin D3 pretreatment regulates renal inflammatory responses during lipopolysaccharide-induced acute kidney injury
Authors: Xu Shen , Chen Yuan-Hua , Tan Zhu-Xia , Xie Dong-Dong , Zhang Cheng , Zhang Zhi-Hui , Wang Hua , Zhao Hui , Yu De-Xin , Xu De-Xiang 
Published: December 2015

AbstractVitamin D receptor (VDR) is highly expressed in human and mouse kidneys. Nevertheless, its functions remain obscure. This study investigated the effects of vitamin D3 (VitD3) pretreatment on renal inflammation during lipopolysaccharide (LPS)-induced acute kidney injury. Mice were intraperitoneally injected with LPS. In VitD3 + LPS group, mice were pretreated with VitD3 (25 μg/kg) at 48, 24 and 1 h before LPS injection. As expected, an obvious reduction of renal function and pathological damage was observed in LPS-treated mice. VitD3 pretreatment significantly alleviated LPS-induced reduction of renal function and pathological damage. Moreover, VitD3 pretreatment attenuated LPS-induced renal inflammatory cytokines, chemokines and adhesion molecules. In addition, pretreatment with 1,25(OH)2D3, the active form of VitD3, alleviated LPS-induced up-regulation of inflammatory cytokines and chemokines in human HK-2 cells, a renal tubular epithelial cell line, in a VDR-dependent manner. Further analysis showed that VitD3, which activated renal VDR, specifically repressed LPS-induced nuclear translocation of nuclear factor kappa B (NF-κB) p65 subunit in the renal tubules. LPS, which activated renal NF-κB, reciprocally suppressed renal VDR and its target gene. Moreover, VitD3 reinforced the physical interaction between renal VDR and NF-κB p65 subunit. These results provide a mechanistic explanation for VitD3-mediated anti-inflammatory activity during LPS-induced acute kidney injury.
Tractography-based Parcellation of the Human Middle Temporal Gyrus
Authors: Xu Jinping , Wang Jiaojian , Fan Lingzhong , Li Hai , Zhang Wen , Hu Qingmao , Jiang Tianzi 
Published: December 2015

AbstractThe middle temporal gyrus (MTG) participates in a variety of functions, suggesting the existence of distinct functional subregions. In order to further delineate the functions of this brain area, we parcellated the MTG based on its distinct anatomical connectivity profiles and identified four distinct subregions, including the anterior (aMTG), middle (mMTG), posterior (pMTG) and sulcus (sMTG). Both the anatomical connectivity patterns and the resting-state functional connectivity patterns revealed distinct connectivity profiles for each subregion. The aMTG was primarily involved in the default mode network, sound recognition and semantic retrieval. The mMTG was predominantly involved in the semantic memory and semantic control networks. The pMTG seems to be a part of the traditional sensory language area. The sMTG appears to be associated with decoding gaze direction and intelligible speech. Interestingly, the functional connectivity with Brodmann’s Area (BA) 40, BA 44 and BA 45 gradually increased from the anterior to the posterior MTG, a finding which indicated functional topographical organization as well as implying that language processing is functionally segregated in the MTG. These proposed subdivisions of the MTG and its functions contribute to understanding the complex functions of the MTG at the subregional level.