bluuebunny/crossref_metadata_2025_split huggingface dataset:
Per Rectal Bleeding in Children: Experiences in the Department of Paediatric Surgery in BSMMU
Authors: Alam Shoheli , Islam K.M. Didarul , Mahammad Noor , Nooruzzaman Md. 
Published: January 2018

Per rectal bleeding is a frequently encountered clinical complaint in routine medical/surgical practice in paediatric patients. It has different aetiology in both extremes of age. This study was carried out in an attempt to find out causes, presentation and the proper management that can be offered to the affected infants and children.This retrospective study was carried out from January 2012 to December 2014 in the department of Paediatric Surgery of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. All patients presenting with the complaint of per rectal bleeding were included. But patients who needed emergency surgical intervention were excluded from this study. The data were reviewed for gender, age, causes of rectal bleeding and type, number, site, recurrence rate and the modality of treatment employed in children having colorectal polyp. Technetium-labeled red blood cells scans was used for the diagnosis of Meckel's Diverticulum. Complete blood picture and routine stool examination were done for all cases.Most polyp cases were diagnosed with digital rectal examination (DRE). Colonoscopy was performed for some cases in the Paediatric Gastroenterology Department of BSMMU. Also all the rectal polyps and colonic mucosal biopsies taken during colonoscopy submitted to histopathological examination. Per rectal bleeding was the chief complaint in 326 (1.5%) patients Out of 21,533 patients presenting to the outpatient department of Paediatric Surgery of BSMMU, Dhaka, Bangladesh over a period of three years. In this study, it was reviewed 326 patients, among them 208 (63.89%) were boys and 118 (36.19%) were girls. The male female ratio was 1.8:1. The ages ranged from 14 months to 14 years (mean age: 5.8years) at diagnosis. The most common aetiology was juvenile polyps which were found in 209 (64.11%) of the cases. It was to be found that anal fissure in 33 (10.12%) patients, rectal prolapse in 27 (8.2%) patients, non-specific colitis in 15 (4.60%) patients, Meckel's Diverticulitis in 3 (0.9%) patients, juvenile polyposis coli in 5 (1.5%) patients and familial adenomatous polyposis coli (FAP) in 4 (1.2%) patients. However, the cause of per rectal bleeding remained unknown suspecting chronic constipation in 30 (9.20%) patients. No statistically significant differences were observed between males and females as well as different age groups regarding the means of the underlying causes of per rectal bleeding in children(p > 0.05). The prevalence of anal fissure in less than 2 years old patients and juvenile polyps in the 2-6 years old patients were significantly higher than the other causes (p < 0.001). Other causes of per rectal bleeding prevailed in children were more than 2 years old. Colorectal polyps are common causes of per rectal bleeding in children. Proper physical examination including DRE along with the colonoscopy promotes both rapid and accurate diagnosis and the opportunity for immediate therapeutic measures.
Optical and Radio Observations of the T Tauri Binary KH 15D (V582 Mon): Stellar Properties, Disk Mass Limit, and Discovery of a CO Outflow
Authors: Aronow Rachel A. , Herbst William , Hughes A. Meredith , Wilner David J. , Winn Joshua N. 
Published: January 2018

Abstract
We present VRIJHK photometry of the KH 15D T Tauri binary system for the 2015/2016 and 2016/2017 observing seasons. For the first time in the modern (CCD) era, we are seeing Star B fully emerge from behind the trailing edge of the precessing circumbinary ring during each apastron passage. We are, therefore, able to measure its luminosity and color. Decades of photometry on the system now allow us to infer the effective temperature, radius, mass, and age of each binary component. We find our values to be in good agreement with previous studies, including archival photographic photometry from the era when both stars were fully visible, and they set the stage for a full model of the system that can be constructed once radial velocity measurements are available. We also present the first high-sensitivity radio observations of the system, taken with the Atacama Large Millimeter/submillimeter Array and the Submillimeter Array. The respective 2.0 and 0.88 mm observations provide an upper limit on the circumbinary (gas and dust) disk mass of 1.7 M
Jup and reveal an extended CO outflow, which overlaps with the position, systemic velocity, and orientation of the KH 15D system and is certainly associated with it. The low velocity, tight collimation, and extended nature of the emission suggest that the outflow is inclined nearly orthogonal to the line of sight, implying it is also orthogonal to the circumbinary ring. The position angle of the radio outflow also agrees precisely with the direction of polarization of the optical emission during the faint phase. A small offset between the optical image of the binary and the central line of the CO outflow remains a puzzle and possible clue to the jet launching mechanism.
Young Cluster Berkeley 59: Properties, Evolution, and Star Formation
Authors: Panwar Neelam , Pandey A. K. , Samal Manash R. , Battinelli Paolo , Ogura K. , Ojha D. K. , Chen W. P. , Singh H. P. 
Published: January 2018

Abstract
Berkeley 59 is a nearby (∼1 kpc) young cluster associated with the Sh2-171 H ii region. We present deep optical observations of the central ∼2.5 × 2.5 pc2 area of the cluster, obtained with the 3.58 m Telescopio Nazionale Galileo. The V/(V–I) color–magnitude diagram manifests a clear pre-main-sequence (PMS) population down to ∼0.2 M
⊙. Using the near-infrared and optical colors of the low-mass PMS members, we derive a global extinction of A

V
= 4 mag and a mean age of ∼1.8 Myr, respectively, for the cluster. We constructed the initial mass function and found that its global slopes in the mass ranges of 0.2–28 M
⊙ and 0.2–1.5 M
⊙ are −1.33 and −1.23, respectively, in good agreement with the Salpeter value in the solar neighborhood. We looked for the radial variation of the mass function and found that the slope is flatter in the inner region than in the outer region, indicating mass segregation. The dynamical status of the cluster suggests that the mass segregation is likely primordial. The age distribution of the PMS sources reveals that the younger sources appear to concentrate close to the inner region compared to the outer region of the cluster, a phenomenon possibly linked to the time evolution of star-forming clouds. Within the observed area, we derive a total mass of ∼103
M
⊙ for the cluster. Comparing the properties of Berkeley 59 with other young clusters, we suggest it resembles more closely the Trapezium cluster.
Lifting Transit Signals from the Kepler Noise Floor. I. Discovery of a Warm Neptune
Authors: Kunimoto Michelle , Matthews Jaymie M. , Rowe Jason F. , Hoffman Kelsey 
Published: January 2018

Abstract
Light curves from the 4-year Kepler exoplanet hunting mission have been searched for transits by NASA’s Kepler team and others, but there are still important discoveries to be made. We have searched the light curves of 400 Kepler Objects of Interest (KOIs) to find transit signals down to signal-to-noise ratio (S/N) ∼ 6, which is under the limit of S/N ∼ 7.1 that has been commonly adopted as a strict threshold to distinguish between a transit candidate and false alarm. We detect four new and convincing planet candidates ranging in radius from near-Mercury-size to slightly larger than Neptune. We highlight the discovery of KOI-408.05 (period = 637 days; radius = 4.9 R
⊕; incident flux = 0.6 S
⊕), a planet candidate within its host star’s Habitable Zone. We dub this planet a “warm Neptune,” a likely volatile-rich world that deserves closer inspection. KOI-408.05 joins 21 other confirmed and candidate planets in the current Kepler sample with semimajor axes a > 1.4 au. These discoveries are significant as a demonstration that the S/N threshold for detection used by the Kepler project is open to debate.
A Comparison of the X-Ray Emission from Tidal Disruption Events with those of Active Galactic Nuclei
Authors: Auchettl Katie , Ramirez-Ruiz Enrico , Guillochon James 
Published: January 2018

Abstract
One of the main challenges of current tidal disruption events (TDEs) studies is that emission arising from active galactic nucleus (AGN) activity may potentially mimic the expected X-ray emission of a TDE. Here we compare the X-ray properties of TDEs and AGNs to determine a set of characteristics that would allow us to discriminate between flares arising from these two objects. We find that at peak, TDEs are brighter than AGNs found at similar redshifts. However, compared to pre-flare upper limits, highly variable AGNs can produce flares of a similar order of magnitude as those seen from X-ray TDEs. Nevertheless, TDEs decay significantly more monotonically, and their emission exhibits little variation in spectral hardness as a function of time. We also find that X-ray TDEs are less absorbed, and their emission is much softer than the emission detected from AGNs found at similar redshifts. We derive the X-ray luminosity function (LF) for X-ray TDEs using the events from Auchettl et al. Interestingly, our X-ray LF closely matches the theoretically derived LF by Milosavljević et al., which assumes a higher TDE rate currently estimated from observations. Using our results and the results of Stone & Metzger, we estimate a TDE rate of (0.7–4.7) × 10−4 year−1 per galaxy, higher than current observational estimates. We find that TDEs can contribute significantly to the LF of AGNs for z ≲ 0.4, while there is no evidence that TDEs influence the growth of 106–7
M
⊙ BHs. However, BHs < 106
M
⊙ can grow from TDEs arising from super-Eddington accretion without contributing significantly to the observed AGN LF at z = 0.
Three-dimensional Forward-fit Modeling of the Hard X-Ray and Microwave Emissions of the 2015 June 22 M6.5 Flare
Authors: Kuroda Natsuha , Gary Dale E. , Wang Haimin , Fleishman Gregory D. , Nita Gelu M. , Jing Ju 
Published: January 2018

Abstract
The well-established notion of a “common population” of the accelerated electrons simultaneously producing the hard X-ray (HXR) and microwave (MW) emission during the flare impulsive phase has been challenged by some studies reporting the discrepancies between the HXR-inferred and MW-inferred electron energy spectra. The traditional methods of spectral inversion have some problems that can be mainly attributed to the unrealistic and oversimplified treatment of the flare emission. To properly address this problem, we use a nonlinear force-free field (NLFFF) model extrapolated from an observed photospheric magnetogram as input to the three-dimensional, multiwavelength modeling platform GX Simulator and create a unified electron population model that can simultaneously reproduce the observed HXR and MW observations. We model the end of the impulsive phase of the 2015 June 22 M6.5 flare and constrain the modeled electron spatial and energy parameters using observations made by the highest-resolving instruments currently available in two wavelengths, the Reuven Ramaty High Energy Solar Spectroscopic Imager for HXR and the Expanded Owens Valley Solar Array for MW. Our results suggest that the HXR-emitting electron population model fits the standard flare model with a broken power-law spectrum (

keV) that simultaneously produces the HXR footpoint emission and the MW high-frequency emission. The model also includes an “HXR-invisible” population of nonthermal electrons that are trapped in a large volume of magnetic field above the HXR-emitting loops, which is observable by its gyrosynchrotron radiation emitting mainly in the MW low-frequency range.
Cosmic Shear with Einstein Rings
Authors: Birrer Simon , Refregier Alexandre , Amara Adam 
Published: January 2018

Abstract
We explore a new technique to measure cosmic shear using Einstein rings. In Birrer et al., we showed that the detailed modeling of Einstein rings can be used to measure external shear to high precision. In this Letter, we explore how a collection of Einstein rings can be used as a statistical probe of cosmic shear. We present a forecast of the cosmic shear information available in Einstein rings for different strong lensing survey configurations. We find that, assuming that the number density of Einstein rings in the COSMOS survey is representative, future strong lensing surveys should have a cosmological precision comparable to the current ground-based weak lensing surveys. We discuss how this technique is complementary to the standard cosmic shear analyses since it is sensitive to different systematics and can be used for cross-calibration.
Large Magneto-ionic Variations toward the Galactic Center Magnetar, PSR J1745-2900
Authors: Desvignes G. , Eatough R. P. , Pen U. L. , Lee K. J. , Mao S. A. , Karuppusamy R. , Schnitzeler D. H. F. M. , Falcke H. , Kramer M. , Wucknitz O. , Spitler L. G. , Torne P. , Liu K. , Bower G. C. , Cognard I. , Lyne A. G. , Stappers B. W. 
Published: January 2018

Abstract
Polarized radio emission from PSR J1745−2900 has already been used to investigate the strength of the magnetic field in the Galactic center (GC), close to Sagittarius A*. Here we report how persistent radio emission from this magnetar, for over four years since its discovery, has revealed large changes in the observed Faraday rotation measure (RM), by up to 3500 rad m−2 (a 5% fractional change). From simultaneous analysis of the dispersion measure, we determine that these fluctuations are dominated by variations in either the projected magnetic field or the free electron content within the GC, along the changing line of sight to the rapidly moving magnetar. From a structure function analysis of RM variations, and a recent epoch of rapid change of RM, we determine a minimum scale of magneto-ionic fluctuations of size ∼2 au at the GC distance, inferring PSR J1745−2900 is just ∼0.1 pc behind an additional scattering screen.
La place des ‘risk managers’ dans l’organisation. Analyse sur la période d’émergence de la fonction ‘risk manager’ en France
Authors: Aubry Caroline 
Published: January 2018

L’objectif de cet article est de comprendre, sur la période d’émergence de la fonction, la place des ‘risk managers’ dans l’organisation. Un cadre conceptuel construit à partir des travaux sur les services fonctionnels permet de l’analyser autour de deux dimensions : client, autorité. L’analyse réalisée à partir d’entretiens menés dans treize entreprises identifie l’individu ou le groupe d’individus pour lequel ils travaillent, détermine leur degré d’autorité dans le processus de décision et les facteurs de cette autorité, en propose une lecture autour de la légitimité.
IL-27p28 Production by XCR1+ Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8+ T Cell Responses
Authors: Kilgore Augustus M , Welsh Seth , Cheney Elizabeth E , Chitrakar Alisha , Blain Trevor J , Kedl Benjamin J , Hunter Chris A , Pennock Nathan D , Kedl Ross M 
Published: January 2018

Abstract
It is well accepted that the innate response is a necessary prerequisite to the formation of the adaptive response. This is true for T cell responses against infections or adjuvanted subunit vaccination. However, specific innate parameters with predictive value for the magnitude of an adjuvant-elicited T cell response have yet to be identified. We previously reported how T cell responses induced by subunit vaccination were dependent on the cytokine IL-27. These findings were unexpected, given that T cell responses to an infection typically increase in the absence of IL-27. Using a novel IL-27p28–eGFP reporter mouse, we now show that the degree to which an adjuvant induces IL-27p28 production from dendritic cells and monocytes directly predicts the magnitude of the T cell response elicited. To our knowledge, these data are the first to identify a concrete innate correlate of vaccine-elicited cellular immunity, and they have significant practical and mechanistic implications for subunit vaccine biology.
Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization
Authors: Zhang Wei , Kim Hajeong , Lv Jiyang , Zhao Na , Ma Xiaojing 
Published: January 2018

Abstract
Golgi phosphoprotein 2 (GOLPH2), a widely expressed Golgi type II transmembrane protein, has been implicated in several important physiological and pathological processes, including virus infections, cancer cell proliferation, and metastasis. However, its biological functions and mechanisms, particularly in the immune system, remain highly obscure. In this study, we report the biochemical identification of GOLPH2 from B cell lymphoma culture supernatant and show that the secreted protein could inhibit IL-12 production by dendritic cells (DCs) and IL-12–induced IFN-γ production by activated T cells. Further molecular analysis revealed that GOLPH2’s IL-12–inhibiting activity was mediated through a proximal IL12p35 promoter element involving a previously identified transcriptional repressor named GC-binding protein that is induced during phagocytosis of apoptotic cells by macrophages. We subsequently generated global golph2 knockout mice, which exhibited little developmental abnormality but were more susceptible to LPS-induced endotoxic shock than were wild-type mice with elevated serum IL-12 levels. Furthermore, we found that GOLPH2 played a regulatory role in macrophage polarization toward the M2 type. A comprehensive analysis of gene expression profiles of activated wild-type and GOLPH2-deficient DCs by RNA sequencing uncovered mechanistic insights into the way GOLPH2 potentially modulates DC function during inflammatory insults. Our functional study of GOLPH2 helps advance the scientific understanding of the biological and pathogenic roles of this novel and intriguing molecule with great potential as a diagnostic and prognostic marker as well as a therapeutic target in many acute and chronic inflammatory disorders.
Need for appropriate specimen for microbiology diagnosis of chronic osteomyelitis
Authors: Vemu Lakshmi , Sudhaharan Sukanya , Mamidi Neeraja , Chavali Padmasri 
Published: January 2018

Abstract
INTRODUCTION: Chronic osteomyelitis (COM) is a common infection, especially in developing countries. An adequate bone biopsy specimen processed with appropriate microbiology culture methods for isolation and identification of the causative organisms is considered as the gold standard for the diagnosis of osteomyelitis.
MATERIALS AND METHODS: The present study is a retrospective microbiology analysis of the specimen from 219 clinically diagnosed cases of COM between January 2013 and April 2016.
RESULTS: The overall culture positivity was 111/219 (50. 6%), colonization was seen in 22/219 (10.5%), while the rest 86/219 (39.3%) were culture-negative specimen; culture positivity was highest from tissue specimen (71/113, 62.8%). Among the swabs, 40/106 (37.7%) were culture positive. About 28/40 (70%) culture-positive swabs showed significant growth of Gram-positive organisms. Colonization with skin flora such as diphtheroids and Coagulase-negative Staphylococci was seen in 22/106 (20.7%) of the swabs. Sterile cultures (44/106, 41.6%) were high among the swab specimen. Gram-positives were most common (75/111, 67.56%). Staphylococcus aureus was the predominant organism isolated in 70/111 (63%) cases. Gram-negative bacilli showed a high level of antibiotic resistance.
CONCLUSION: As per our data, the culture yield from wound swabs was low or contaminated with normal skin flora, as compared to the biopsy or tissue specimen. Hence, an appropriate sampling of the infected bone using recommended protocols is highly essential for improving microbiological yield and the outcome of COM.
Role of fine needle aspiration cytology in diagnosis of brown tumor secondary to parathyroid adenoma
Authors: Ojha Sandeep S. , Valecha Jyoti , Sharma Abhishek , Nilkanthe Ramrao 
Published: January 2018

AbstractBrown tumor (BT) is caused by altered metabolism of calcium resulting from hyperparathyroidism (primary or secondary). The most common cause of hyperparathyroidism is isolated parathyroid adenoma (PA), and the most common symptoms are hypercalcemia related. BT is considered as a late manifestation of PA and usually diagnosed after surgical treatment of the bony lesion. Fine-needle aspiration cytology (FNAC) is a cheap, easy, and less traumatic procedure and should be performed in all lesions wherever possible as unnecessary surgeries may be avoided. We here report a rare case of PA presenting primarily as BT and diagnosed on FNAC.
A search for entrustable professional activities for the 1st year pathology postgraduate trainees
Authors: Sharma Pooja , Tanveer Nadeem , Goyal Aditi 
Published: January 2018

Abstract
INTRODUCTION: During the past decade, there has been a paradigm shift in medical education from the problem-based learning to competency-based training. This has forced a rethink on the way we evaluate the residents and finally give them the right to handle patients independently. This study makes the first attempt towards designing competency-based training program for pathology residents by formulating the entrustable professional activities (EPAs) for the 1st year pathology residents.
MATERIALS AND METHODS: A questionnaire comprising 18 potential EPAs in histopathology and 12 potential EPAs in cytology were circulated among the residents of Pathology Department. The respondents were asked to grade the EPAs on a scale of 0–4 based on how important they considered that activity as EPA. The cumulative score of each EPA was divided by the number of respondents to arrive at the average score. The EPAs with an average score of 3 or more qualified to be shortlisted as consensus EPAs.
RESULTS: Five activities each of histopathology and cytopathology had an average score of 3 or above and were shortlisted as EPAs for the 1st year pathology postgraduates. Each of these was also mapped to their respective competencies.
CONCLUSION: There is an urgent need to restructure the postgraduate pathology curriculum in line with competency-based training. This study is the first step in this direction.
Evaluation of new indigenous “point‑of‑care” ABO and Rh grouping device
Authors: Tiwari Aseem Kumar , Setya Divya , Aggarwal Geet , Arora Dinesh , Dara Ravi C. , Ratan Ankita , Bhardwaj Gunjan , Acharya Devi Prasad 
Published: January 2018

Abstract
BACKGROUND: Erycard 2.0 is a “point-of-care” device that is primarily being used for patient blood grouping before transfusion.
MATERIALS AND METHODS: Erycard 2.0 was compared with conventional slide technology for accuracy and time taken for ABO and Rh forward grouping result with column agglutination technology (CAT) being the gold standard. Erycard 2.0 as a device was also evaluated for its stability under different storage conditions and stability of result till 48 h. In addition, grouping of hemolyzed samples was also tested with Erycard 2.0. Ease of use of Erycard 2.0 was evaluated with a survey among paramedical staff.
RESULTS: Erycard 2.0 demonstrated 100% concordance with CAT as compared with slide technique (98.9%). Mean time taken per test by Erycard 2.0 and slide technique was 5.13 min and 1.7 min, respectively. After pretesting storage under different temperature and humidity conditions, Erycard 2.0 did not show any deviation from the result. The result did not change even after 48 h of testing and storage under room temperature. 100% concordance was recorded between pre- and post-hemolyzed blood grouping. Ease of use survey revealed that Erycard 2.0 was more acceptable to paramedical staff for its simplicity, objectivity, and performance than conventional slide technique.
CONCLUSION: Erycard 2.0 can be used as “point-of-care” device for blood donor screening for ABO and Rh blood group and can possibly replace conventional slide technique.