bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embracing Technological Advancement: Assessing the Impact of Innovation on Sectorial Employment in Tanzania
Authors: Mbwambo Seth Kenedi , Mathew Rehema Reuben , Vedasto Valence Chinaboine 
Published: September 2024

Technological innovation is one of the most rapidly advancing and dynamic sector today. It drives growth across all sectors of the economy. However, this rapid growth presents both opportunities and challenges. Taking innovation into account, this study aims to assess the impact of technological innovation on three sectors which are agriculture, industrial, and service sectors. The study employed the autoregressive distributed lag model (ARDL), with data from 2000 to 2022 obtained from the World Bank (WB) and the World Intellectual Property Organization (WIPO). Three ARDL models were used to estimate employment in the agriculture sector, employment in the industrial sector and employment in the service sector with inflation (CPI) and interest rate (INT) as the control variables. The ADF (Augmented Dickey-Fuller) test, PP(Philip-Perron) test, Serial Correlation LM test, BG Heteroscedasticity, and Jarque Bera Normality test were utilized to ensure robust estimates of the models. The findings revealed that innovation has a significant positive influence on employment in the agriculture sector and service sector whereas the industrial sector is negatively influenced by innovation. Nevertheless, inflation has a significant positive effect on employment in the agriculture and service sectors but negatively affects employment in the industrial sector, where a lag in interest rate influence negatively employment in the agricultural sector. Relying on these findings, the study recommends an increase in expenditure on research and development, formulation of policies that will mainstream innovation in all sectors of the economy, and investing more in education and skills development
SOSIALISASI BRANDING PEMPEK KOYEK 7 ULU SEBAGAI BAGIAN DARI BUDAYA KULINER KHAS KOTA PALEMBANG
Authors: Pratiwi Diany Putri , Febrianza Muhammad , Ardiansyah Ardiansyah , Sintia Sintia , Karina Lita 
Published: September 2024

Pempek yang merupakan kuliner khas kota Palembang yang berasal dari olahan daging ikan lalu dicampurkan dengan sagu. Daging ikan yang digunakanpun beragam, seperti ikan tenggiri, ikan gabus, serta ikan kakap. Hal ini telah menciptakan berbagai macam jenis pempek yang ada di kota Palembang, seperti pempek lenjer, pempek kapal selam, pempek keriting, pempek lenggang, pempek pistel, pempek belah, pempek kulit, dan lain sebagainya. Metode yang digunakan penulis dalam tulisan ini adalah metode deskriptif. Menurut Ruslan (2008:12), metode deskriptif bertujuan untuk menggambarkan tentang karakteristik (ciri-ciri ) individu, situasi, atau kelompok tertentu. Metode ini relatif sederhana dan tidak memerlukan landasan teoritis rumit atau pengajuan hipotesis tertentu. Pada penulisan ini, penulis ingin menekankan pada pentingnya branding dan packaging dalam suatu usaha diiringi dengan penggunaan sosial media. Dari hal tesebut diharapkan dapat memudahkan penyebarluasan informasi mengenai Pempek Koyek dan produk-produk kuliner yang dijajahkan. Oleh karena itu, pada tulisan ini, penulis berharap sosialisasi tersebut dapat berguna dan diterapkan dikemudian hari, tidak hanya oleh Pempek Koyek, namun juga warga sekita Kelurahan 7 Ulu
STRATEGI DIGITAL MARKETING KAIN SONGKET PALEMBANG DALAM PENGEMBANGAN UMKM KAMPUNG KEMAS, SEBERANG ULU1 PALEMBANG
Authors: Pahalmas Juniior Zamrud , Pratiwi Diany Putri , Havivi Siti Lady , Widia Putri , Rhamansyah Rendy 
Published: September 2024

Kegiatan ini bertujuan untuk mengembangkan strategi digital marketing dan mengoptimalkan aplikasi di beragam digital platform dengan tujuan membangun bisnis kreatif sebagai upaya meningkatkan sumber manusia yang kreatif dan memiliki keunggulan bersaing di Palembang, bahkan Sumatera Selatan atau bisa sampai pada tingkat nasional. Kegiatan ini menggunakan pendekatan kualitatif dengan tujuannya untuk mengidentifikasi keterkaitan antara pemanfaatan teknologi informasi dan komuniksi dalam membangun ekonomi kreatif dengan pendekatan digital marketing demi meningkatkan pendapatan Unit Mikro, Kecil dan Menengah (UMKM) sebagai moda ekonomi warga Kampung Kemas, Kelurahan 2 Ulu, di Kecamatan Seberang Ulu 1, Kota Palembang. Kaitan antara peran digital marketing dan meningkatnya pendapatan UMKM di Kampung Kemas ini diteliti berdasarkan Teori Kewirausahaan Digital (Digital Entrepreneurship Theory). Dari analisis yang dilakukan, dapat diperoleh hasil kegiatan di lapangan bahwa Kampung Kemas yang memiliki beragam unit usaha ini terlihat ada peluang bisnis yang bagus dalam meningkatkan pendapatan rumah tangga dan mengurangi pengangguran melalui UMKM yang dijalani, hanya saja masih belum cukup edukasi dan motivasi serta inovasi di masyarakat sehingga tidak sampai pada titik maksimalnya dalam menjalankan secara teknis pemanfaatan dari digital markeitng, yaitu komunikasi pemasaran secara online dan keunggulan-keunggulan media sosial lainnya.
DoeDat: Enhanced Roundtripping of Crowdsourced Specimen Annotations
Authors: Dillen Mathias , Trekels Maarten 
Published: September 2024

The DoeDat platform was launched by Meise Botanic Garden in 2018 to capture label data from imaged herbarium specimens by inviting volunteer contributors (Groom et al. 2018). It has since facilitated data capture from specimens of other natural history collections (Helminger et al. 2020, Mitrache et al. 2023), as well as digitised content from various other disciplines, such as historical photographs, posters and postcards. Volunteers may simply transcribe handwritten and/or typed text, but often also interpret the sparse and scattered information on the image, including trying to georeference its original location. As of April 2024, almost 650.000 tasks have been completed, of which more than 470.000 were herbarium specimens from Meise.
DoeDat supports domain standards, including Darwin Core, and follows most of the currently drafted MIDS (Minimum Information about a Digital Specimen) guidelines as to what data is captured for natural history specimens. However, images have to be pre-loaded into the server storage for each project and captured data gets exported as one or more CSV files per project. These data files then still need to be processed before they can be ingested into the local management system (Engledow et al. 2023). Often the data are also subjected to additional quality control before they get openly published. This can result in the pipeline from image to openly published annotations being quite time and labour-consuming.
As the biodiversity infrastructure landscape moves more towards FAIR (Findable, Accessible, Interoperable, Reusable) open data, DoeDat will adapt accordingly. This includes digital objects that are easy to annotate. Furthermore, image servers following IIIF (International Image Interoperability Framework) greatly standardise the access and portability of media content, drastically changing the way images are being dealt with. We envision upgrading the DoeDat platform to load images and any required metadata as IIIF manifests, greatly streamlining the process of adding new content and tracking provenance. The transcriptions should be accessible for external systems, loading the updated image manifests and publishing them as annotations such as nanopublications.
Effect of Land Use/Land Cover Maps on CN Method: Case Study over Kahramanmaras
Authors: Oz Arif , Dis Muhammet Omer 
Published: September 2024

The impact of Land Use/Land Cover (LULC) data obtained from various spatial resolution satellites on the distribution of the Curve Number (CN) across Kahramanmaras using the Soil Conservation Service (SCS)-CN technique was investigated in this research. This study aimed to examine the effect of LULC on runoff due to increasing urbanization in the last century and the conversion of forest areas to agricultural lands. CORINE data with a spatial resolution of 100 m, and Sentinel-2A data with spatial resolutions of 10, 20, and 60 m were utilized in the analysis. The results reveal that only the average CNs of the products are in close proximity, while there are significant discrepancies in the CN variation over the maps as the spatial resolution increases. The Sentinel-2A satellite findings revealed higher CN values compared to the CORINE dataset over the study area where three geographical regions, namely the Mediterranean, Eastern Anatolia, and Southeastern Anatolia. Additionally, the results show that an increase in urbanization triggers surface runoff potential and reduces it in agricultural and forest areas in the city. Thus, the updated and higher spatial resolution of LULC promises accurate flood forecasting and/or more scientific potential drought estimation as well as other hydrological applications.
Viral load non-suppression among adolescents and youth living with HIV in South Africa
Authors: Molopa Lesiba O. , Ginyana Thembelihle P. , Vondo Noloyiso , Magobo Rindidzani , Maseko Goitseone , Zungu Nompumelelo , Zuma Khangelani , Simbayi Leickness , Mabaso Musawenkosi , Moyo Sizulu 
Published: September 2024

Background: Despite the increased initiation and uptake of antiretroviral therapy (ART) in South Africa, some people living with HIV (PLHIV) who are on ART still have non-suppressed viral load (VL).Objectives: This study aimed to determine the prevalence of VL non-suppression among adolescents and youth (aged 12 years – 24 years) living with HIV and on ART in South Africa, as well as the factors associated with it.Method: Data from the 2017 South African national HIV prevalence, incidence, behaviour, and communication survey were analysed. The survey used a multistage-stratified cluster sampling design. A backward stepwise multivariable generalised linear model was used to identify factors associated with VL non-suppression.Results: The study included 340 participants aged 12 years – 24 years, with a median age of 21 (interquartile range [IQR]: 18–23). The proportion of adolescents and youth living with HIV and on ART with non-suppressed VL was 19.2% (95% confidence interval [CI]: 14.4–25.3). Approximately 60% of the participants were not on ART. The odds of VL non-suppression were significantly higher among youth aged 15 years – 19 years (adjusted odds ratio [AOR] = 1.63 [95% CI: 1.24–2.13], p = 0.001) and aged 20 years – 24 years (AOR = 1.22 [95% CI: 1.06–1.41], p = 0.005) compared to adolescents aged 12 years – 14 years. The odds were significantly lower among individuals of other races (AOR = 0.80 [95% CI: 0.69–0.92], p = 0.003) compared to black African people.Conclusion: Findings suggest a need for ART education and counselling as part of treatment support. In addition, the promotion of HIV awareness as part of strengthening the HIV treatment and prevention cascade.Contribution: The article showed the prevalence of VL non-suppression and associated factors among adolescents and youth.
Computed tomography-based radiomic model for the prediction of neoadjuvant immunochemotherapy response in patients with advanced gastric cancer
Authors: Zhang Jun , Wang Qi , Guo Tian-Hui , Gao Wen , Yu Yi-Miao , Wang Rui-Feng , Yu Hua-Long , Chen Jing-Jing , Sun Ling-Ling , Zhang Bi-Yuan , Wang Hai-Ji 
Published: September 2024

BACKGROUND
Neoadjuvant immunochemotherapy (nICT) has emerged as a popular treatment approach for advanced gastric cancer (AGC) in clinical practice worldwide. However, the response of AGC patients to nICT displays significant heterogeneity, and no existing radiomic model utilizes baseline computed tomography to predict treatment outcomes.
AIM
To establish a radiomic model to predict the response of AGC patients to nICT.
METHODS
Patients with AGC who received nICT (n = 60) were randomly assigned to a training cohort (n = 42) or a test cohort (n = 18). Various machine learning models were developed using selected radiomic features and clinical risk factors to predict the response of AGC patients to nICT. An individual radiomic nomogram was established based on the chosen radiomic signature and clinical signature. The performance of all the models was assessed through receiver operating characteristic curve analysis, decision curve analysis (DCA) and the Hosmer-Lemeshow goodness-of-fit test.
RESULTS
The radiomic nomogram could accurately predict the response of AGC patients to nICT. In the test cohort, the area under curve was 0.893, with a 95% confidence interval of 0.803-0.991. DCA indicated that the clinical application of the radiomic nomogram yielded greater net benefit than alternative models.
CONCLUSION
A nomogram combining a radiomic signature and a clinical signature was designed to predict the efficacy of nICT in patients with AGC. This tool can assist clinicians in treatment-related decision-making.
Small particle drug-eluting beads-transarterial chemoembolization combined with targeted therapy in the clinical treatment of unresectable liver cancer
Authors: Qi Jing-Song , Zhao Peng , Zhao Xiao-Bo , Zhao Yong-Li , Guo Ying-Chang 
Published: September 2024

BACKGROUND
Liver cancer is a highly malignant tumor with significant clinical impact. Chemotherapy alone often yields suboptimal outcomes in both the short and long term, characterized by high rates of local recurrence and distant metastasis, leading to a poor long-term prognosis.
AIM
To evaluate the clinical efficacy of small particle drug-eluting beads-transarterial chemoembolization (DEB-TACE) combined with targeted therapy for the treatment of unresectable liver cancer.
METHODS
We analyzed clinical data from 74 patients with unresectable liver cancer admitted between January 2019 and December 2020. Based on the different treatment regimens administered, patients were divided into the control (36 patients receiving sorafenib alone) and joint (38 patients receiving small particle DEB-TACE combined with sorafenib) groups. We compared liver function indicators [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), albumin (ALB)] and serum tumor markers [alpha fetoprotein (AFP)] before and after treatment in both groups. Short-term efficacy measures [complete response (CR), partial response, progression disease, stable disease, objective response rate (ORR), and disease control rate (DCR)] were assessed post-treatment. Long-term follow-up evaluated median overall survival (OS), progression-free survival (PFS), and adverse reaction rates between the two groups.
RESULTS
One month post-treatment, the joint group demonstrated significantly higher rates of CR, ORR, and DCR compared to the control group (P < 0.05). Three days after treatment, the joint group showed elevated levels of ALT, AST, and TBIL but reduced levels of ALB and AFP compared to the control group (P < 0.05). The median OS was 18 months for the control group and 25 months for the joint group, while the median PFS was 15 months for the control group and 22 months for the joint group, with significant differences observed (log-rank: χ 2 = 7.824, 6.861, respectively; P = 0.005, 0.009, respectively). The incidence of adverse reactions was not significantly different between the groups (P > 0.05).
CONCLUSION
The combination of small particle DEB-TACE and sorafenib significantly improves both short- and long-term outcomes in the treatment of unresectable liver cancer while preserving liver function.
Intratumoural microorganism can affect the progression of hepatocellular carcinoma
Authors: Liu Bao-Qun , Bai Yi , Chen Da-Peng , Zhang Ya-Min , Wang Tian-Ze , Chen Jing-Rui , Liu Xiang-Yu , Zheng Bin , Cui Zi-Lin 
Published: September 2024

BACKGROUND
Several recent studies have confirmed that intratumoural microorganisms can affect the occurrence and development of hepatocellular carcinoma (HCC); however, their role in tumor progression remains unclear. Hence, there is a need for further research on the role of intratumoural microorganisms in HCC.
AIM
To investigate the changes in intratumoural microorganisms in HCC and the effect of Propionibacterium on HCC progression.
METHODS
HCC and normal liver tissue specimens were subjected to fluorescence in situ hybridization (FISH). After performing 16S rRNA sequencing on HCC and peritumoral tissues to analyze the differences between the two groups. Propionibacterium was cocultured with HCC cells in vitro . Changes in cell proliferation and migration capacity were evaluated. The expression of NF-κB pathway related proteins in tumor cells was compared. The orthotopic liver implantation model and the subcutaneous xenograft model were constructed. liver tissues and subcutaneous tumors were collected 2 weeks later.
RESULTS
FISH demonstrated the presence of microorganisms in HCC and normal liver tissues. 16S rRNA sequencing revealed an abundance of Lysobacter , Lachnospiraceae , Pseudomonas , and Lactobacillus in HCC tissues. The distribution and abundance of Propionibacterium showed differences between HCC and peritumoral tissues (P < 0.05). In vitro studies demonstrated that Propionibacterium and its metabolite propionic acid (PA) inhibited the proliferation and migration of HCC cells (P < 0.05). The expression of the proteins in NF-κB signaling pathway also decreased in HCC cells (P < 0.05).
CONCLUSION
Microorganisms in HCC and normal liver tissues displayed significant disparities. The PA-producing bacterium Propionibacterium in HCC exerts an effect on the NF-κB pathway, thereby affecting the biological behavior of HCC.
Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma
Authors: Wang Xiao-Wei , Tang Yu-Xing , Li Fu-Xi , Wang Jia-Le , Yao Gao-Peng , Zeng Da-Tong , Tang Yu-Lu , Chi Bang-Teng , Su Qin-Yan , Huang Lin-Qing , Qin Di-Yuan , Chen Gang , Feng Zhen-Bo , He Rong-Quan 
Published: September 2024

BACKGROUND
Hepatocellular carcinoma (HCC) is a major health challenge with high incidence and poor survival rates in China. Systemic therapies, particularly tyrosine kinase inhibitors (TKIs), are the first-line treatment for advanced HCC, but resistance is common. The Rho GTPase family member Rho GTPase activating protein 12 (ARHGAP12), which regulates cell adhesion and invasion, is a potential therapeutic target for overcoming TKI resistance in HCC. However, no studies on the expression of ARHGAP12 in HCC and its role in resistance to TKIs have been reported.
AIM
To unveil the expression of ARHGAP12 in HCC, its role in TKI resistance and its potential associated pathways.
METHODS
This study used single-cell RNA sequencing (scRNA-seq) to evaluate ARHGAP12 mRNA levels and explored its mechanisms through enrichment analysis. CellChat was used to investigate focal adhesion (FA) pathway regulation. We integrated bulk RNA data (RNA-seq and microarray), immunohistochemistry and proteomics to analyze ARHGAP12 mRNA and protein levels, correlating with clinical outcomes. We assessed ARHGAP12 expression in TKI-resistant HCC, integrated conventional HCC to explore its mechanism, identified intersecting FA pathway genes with scRNA-seq data and evaluated its response to TKI and immunotherapy.
RESULTS
ARHGAP12 mRNA was found to be highly expressed in malignant hepatocytes and to regulate FA. In malignant hepatocytes in high-score FA groups, MDK-[integrin alpha 6 (ITGA6) + integrin β-1 (ITGB1)] showed specificity in ligand-receptor interactions. ARHGAP12 mRNA and protein were upregulated in bulk RNA, immunohistochemistry and proteomics, and higher expression was associated with a worse prognosis. ARHGAP12 was also found to be a TKI resistance gene that regulated the FA pathway. ITGB1 was identified as a crossover gene in the FA pathway in both scRNA-seq and bulk RNA. High expression of ARHGAP12 was associated with adverse reactions to sorafenib, cabozantinib and regorafenib, but not to immunotherapy.
CONCLUSION
ARHGAP12 expression is elevated in HCC and TKI-resistant HCC, and its regulatory role in FA may underlie the TKI-resistant phenotype.
Management of Intramural Uterine Fibroid by Ayurveda - A case study
Authors: Geetika  , Jayashree Patil  , Umang Varshney  , Shubham Gupta  
Published: September 2024

Too many female gynaecological issues are a result of shifting food habits and lifestyles. One of the main concerns for women who are of reproductive age is uterine fibroids. The symptoms of uterine fibroids have a detrimental effect on women's well-being, their ability to engage in social and physical activities, and their productivity at work. A 25-year-old married female patient arrived at the outpatient clinic complaining of lower abdominal pain, heavy menstrual flow, burning during micturition, and white discharge coming from her vagina six months ago . An intrauterine fibroid measuring 24 x 10 mm size with an ET of 10.5 mm was seen during the ultrasound examination. The ovaries' B/L measurements were normal, and the wall of the gallbladder was slightly enlarged. Surgery was recommended for the same condition, but the patient refused to have it done and preferred non-hormonal treatment. The patient refused to take any allopathic medication. The patient sought Ayurvedic treatment at the OPD. She received treatment in accordance with the Ayurvedic regimen prescribed by Kanchanar Guggulu, Kuberaksha vati, Raktavardhak vati, Ashoka-arishta, Hingwashtak churna, Chandraprabha vati, Kumaryaasawa.After three months of treatment and a follow-up every 15 days, a repeat scan showed normal results and symptom alleviation.
Conversion of CII Opioid Medications to Buprenorphine in the Chronic Pain Population - Insights and Clinical Pearls
Authors: Zimmerman Amanda 
Published: September 2024

Background: There is a great deal of confusion associated with conversion from CII opioid to buprenorphine products. The data presented supports that patients can be converted from high dose opioid medication to buprenorphine products safely and effectively. This presentation will provide a road map to help guide practitioners who are interested in applying this to their clinical practice.
Purpose/hypothesis: The purpose of the research was not only to discover if conversion to a partial agonist CIII medication from full agonist CII medications would be achieveable without sacrificing analgesia, but also to provide guidance to providers who are interested in pursuing this option in clinical practice.
Procedures/data/observations: Patients who met inclusion criteria were stratified into subgroups on the basis of preconversion morphine milligram equivalents, whether they remained on opioids for breakthrough pain post-conversion, and pre- and post-conversion numerical rating scale pain scores. Outcomes of interest included the differences between pre- and post-conversion numerical rating scale pain scores and daily morphine milligram equivalents for each subgroup. Of 157 patients reviewed, 87.9% were successfully converted to buprenorphine buccal film. Overall, numerical rating scale pain scores were stable after conversion. Statistically significant reductions were demonstrated in the <90 daily morphine milligram equivalent subgroup. Post-conversion daily morphine milligram equivalents decreased by 85.4% from baseline. Change in daily morphine milligram equivalents is representative of patients who remained on breakthrough pain medication.
Conclusions/applications: Results demonstrate continued analgesia after conversion to buprenorphine buccal film despite reductions in daily morphine milligram equivalents. Most patients were able to convert directly from their long-acting opioid to buprenorphine buccal film and sta- bilized without the use of concomitant opioids for breakthrough pain. Aggressive titration strategies were associated with greater success. This data proves that conversion from full agonist CII medications is possible without sacrificing analgesia while reducing the risk of adverse events associated with full agonist CII medications.