bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I clinical trial of NH130 and the prediction of its pharmacokinetics using physiologically based pharmacokinetic modeling
Authors: Zhang Kun , Zhao Shanshan , Du Jialin , Zhang Lan 
Published: September 2024

BackgroundParkinson’s disease psychosis (PDP) is a common and distressing complication of Parkinson’s disease (PD), characterized by hallucinations and delusions. This research aimed to assess the pharmacokinetics and safety of NH130, a selective serotonin 5-HT2A inverse agonist, as a potential PDP treatment in healthy individuals.MethodsWe conducted clinical pharmacokinetic studies and safety evaluations for NH130, employing a physiologically based pharmacokinetic (PBPK) model to predict its behavior in human body.ResultsIn a single-dose escalation study, healthy volunteers received NH130 at varying doses (2 mg, 6 mg, 12 mg, 24 mg, 40 mg, 60 mg, and 90 mg) or a placebo. The drug demonstrated favorable pharmacokinetics, with no serious adverse events (AEs) reported. Clinical plasma concentrations correlated well with PBPK model predictions, validating the model’s utility for guiding future clinical development.ConclusionNH130 showed promising pharmacokinetic characteristics and safety profile, supporting its progression to multi-dose trials and suggesting its potential as a therapeutic agent for PDP.Clinical Trial Registrationhttp://www.chinadrugtrials.org.cn/index.html, Identifier CTR20230409.
Double burden of malnutrition among women and children in Zimbabwe: a pooled logistic regression and Oaxaca-Blinder decomposition analysis
Authors: Lukwa Akim Tafadzwa , Chiwire Plaxcedes , Akinsolu Folahanmi Tomiwa , Okova Denis , Hongoro Charles 
Published: September 2024

BackgroundThe double burden of malnutrition (DBM) is a public health issue characterised by the coexistence of undernutrition and overnutrition within the same population, household, or individual. Undernutrition, manifesting as stunting, wasting, or being underweight, results from insufficient nutrient intake while overnutrition, manifesting as overweight or obesity, results from excessive caloric intake, poor diet quality, and sedentary lifestyles. This dual burden poses significant challenges for health systems due to lost productivity and increased healthcare expenditure.MethodsThis study utilised data from the Demographic and Health Surveys (DHS) conducted in Zimbabwe for 2010–2011 and 2015, which provided information on women’s and children’s health and nutritional status, household characteristics, and socio-economic status. Pooled logistic regression was used to analyse the association between various sociodemographic factors and DBM among women and children. The Oaxaca-Blinder decomposition method explored differences in DBM between 2010–2011 and 2015.ResultsThe average age of mothers was approximately 31 years, and children’s ages averaged around 32 months. From 2010 to 2015, there was a notable socio-economic improvement, with a decrease in the percentage of mothers in the poorest quartile from 20 to 16% and an increase in the richest quartile from 22 to 23%. The study found a slight decrease in overall household DBM among women from 34% in 2010 to 32% in 2015, while DBM among children increased from 12 to 14%. Pooled logistic regression analysis indicated that children in rural areas had statistically significantly higher odds of experiencing DBM than their urban counterparts. The Oaxaca-Blinder decomposition showed that changes in residence status significantly impacted the increase in DBM among children. At the same time, the coefficient effect accounted for most of the unexplained differences in DBM among women.ConclusionThe growing DBM among women and children in Zimbabwe is significantly influenced by changes in residence status. The findings highlight the need for targeted public health interventions to address urban–rural disparities and emphasise the importance of considering socio-economic, environmental, and behavioural factors. Context-specific public health strategies, aligned with WHO’s Double Duty Actions, are essential to improve the nutritional health of Zimbabwe’s population.
DEVELOPMENT OF VIDEO ANIMATION-BASED LEARNING MEDIA TO IMPROVE ELEMENTARY SCHOOL STUDENTS' LISTENING SKILLS
Authors: Fitra Itun Desiana , Widiastuti Sripit , Fauzi Adin 
Published: September 2024

The objective of this research is to develop animation-based video media suitable for delivering reading materials of three text types (simple procedures, explanations, and objective descriptions) to fifth-grade elementary school students. This research utilizes a Research and Development design, commonly known as developmental research. Due to the ongoing Covid-19 pandemic, readability testing is conducted with 5 fifth- grade students from UPT SD Negeri Talun 05 and 5 elementary school teachers. Data collection techniques include surveys and documentation. Both quantitative and qualitative descriptive analyses are employed for data analysis in this research. The expert assessment of the content yields a 91% rating, categorized as highly feasible. The media expert evaluation results in a 90% rating, indicating the media is highly feasible. The language expert assessment produces an 88% matching category percentage. Students exhibit excellent performance in readability experiments, scoring 90% in the very good category, and they demonstrate a strong preference for animation-based video content. Teachers score remarkably high at 94% in readability testing. Consequently, teachers can consider animation-based media as a reference for Indonesian language learning that covers materials with three text types studied by fifth-grade elementary school classes: simple procedural text, explanation, and objective description.
TERAPIA DE REPOSIÇÃO HORMONAL: BENEFÍCIOS E RISCOS DURANTE A MENOPAUSA
Authors: Melo Ana Beatriz Oliveira de , Nascimento Maria Eduarda Bezerra do , Gitai Alice Maria Plácido Caldas , Silva Andreza Balbino da , Fontenele Laís de Souza , Aguiar Priscila Silva , Esteves Ryan Farias , Oliveira Jullia Martins de , Campanete Acsa Lia , Façanha Eliomara Brito , Siqueira Helainy de Souza , Cavalcanti Ana Luiza Batista 
Published: September 2024

Introdução: A Terapia de Reposição Hormonal (TRH) é um tratamento frequentemente utilizado para aliviar os sintomas da menopausa, como ondas de calor, suores noturnos e alterações de humor. Consiste na administração de hormônios femininos, estrogênio e, frequentemente, progesterona, para compensar a diminuição natural desses hormônios durante a menopausa. Embora a TRH possa oferecer benefícios significativos, como a melhoria da qualidade de vida e a prevenção da perda óssea, também está associada a riscos, incluindo o aumento da probabilidade de doenças cardiovasculares e cânceres hormonodependentes. A decisão de iniciar a TRH deve ser cuidadosamente considerada, levando em conta os benefícios individuais e os potenciais efeitos adversos. Objetivo: Avaliar os benefícios e riscos da terapia de reposição hormonal (TRH) durante a menopausa, analisando sua eficácia no alívio dos sintomas. Metodologia: A pesquisa foi realizada através do acesso online nas bases de dados National Library of Medicine (MEDLINE), Scientific Electronic Library Online (SCIELO), literatura latino-americana e do Caribe em Ciências da Saúde (LILACS) no mês de agosto de 2024. Resultados e Discussão: A Terapia de Reposição Hormonal (TRH) demonstrou ser eficaz na redução dos sintomas da menopausa, como ondas de calor e distúrbios do sono, além de ajudar na manutenção da saúde óssea. No entanto, os riscos associados, como o aumento de doenças cardiovasculares e certos tipos de câncer, foram significativos, particularmente com o uso prolongado. A discussão aponta que a TRH deve ser individualizada, considerando o histórico médico e os fatores de risco pessoais, e recomenda uma avaliação contínua dos benefícios e riscos para otimizar o tratamento e minimizar os efeitos adversos. Considerações Finais: A Terapia de Reposição Hormonal (TRH) é eficaz no alívio dos sintomas da menopausa e na prevenção da perda óssea, mas também apresenta riscos significativos, como doenças cardiovasculares e cânceres hormonodependentes. A decisão de iniciar a TRH deve ser baseada em uma avaliação cuidadosa dos benefícios e riscos individuais, e o tratamento deve ser ajustado conforme necessário para garantir a melhor qualidade de vida com o menor risco possível.
Introduction to the Application of Kaizen Principles in the World of Work, For the Students of SMK.N 43 Jakarta
Authors: Lis Lesmini  , Vica Nurhayani  , Tri Mulyani Setyowati  , Dian Anom Baskoro  , Krisman Damanik  
Published: September 2024

The purpose of this activity is to provide an introduction to the application of Kaizen principles in the world of work for the students of SMK.N 43 Jakarta. This activity is part of an effort to introduce the concept of continuous improvement to students because the Kaizen principle has great relevance in the context of the ever-changing modern world of work as well as in the daily lives of students. The activity was carried out directly at SMK.N 43, on Wednesday 7 February 2024 through the provision of basic Kaizen knowledge, case examples, video screenings, games and interactive discussions. The activity was attended by 40 people, consisting of 35 students, 4 ITL Trisakti Team Lecturers, and 1 student. From the results of the interview, it is known that the partner's problem is the desire to increase students' knowledge of the principles that apply in the world of work. Based on the results of the analysis of the pre-test and post-test, each of which consists of 10 indicators, it is found that there is an increase in participant understanding between 22% to 101%, with an average increase in understanding of 63.1% for each indicator.
The Distribution of Planet Radius in Kepler Multiplanet Systems Depends on Gap Complexity
Authors: Rice David R. , Steffen Jason H. , Vazan Allona 
Published: September 2024

Abstract
The distribution of small planet radius (<4 R
⊕) is an indicator of the underlying processes governing planet formation and evolution. We investigate the correlation between the radius distribution of exoplanets in Kepler multiplanet systems and the system-level complexity in orbital period spacing. Utilizing a sample of 234 planetary systems with three or more candidate planets orbiting FGK main-sequence stars, we measure the gap complexity (C) to characterize the regularity of planetary spacing and compare it with other measures of period spacing and spacing uniformity. We find that systems with higher gap complexity exhibit a distinct radius distribution compared to systems with lower gap complexity. Specifically, we find that the radius valley, which separates super-Earths and sub-Neptunes, is more pronounced in systems with lower gap complexity (C < 0.165). Planets in high-complexity systems (C > 0.35) exhibit a lower frequency of sub-Earths (2.5 times less) and sub-Neptunes (1.3 times less) and a higher frequency of super-Earths (1.4 times more) than planets in low-complexity systems. This may suggest that planetary systems with more irregular spacings are more likely to undergo dynamic interactions that influence planet scattering, composition, and atmospheric retention. The gap complexity metric proves to be a valuable tool in linking the orbital configurations of planets to their physical characteristics.
Groups with finitely many Busemann points
Authors: Ron-George Liran , Yadin Ariel 
Published: September 2024

We show that an infinite finitely generated group

G

is virtually

\mathbb{Z}

if and only if every Cayley graph of

G

contains only finitely many Busemann points in its horofunction boundary. This complements a previous result of the second named author and M. Tointon.
Networking capability and sustainable competitive advantage of small and medium food manufacturing enterprises in Kenya
Authors: Kimaru Elizabeth , Ngugi Patrick Karanja , Mugambi Allan 
Published: September 2024

In every country's economic development objective, manufacturing firms owned by small and medium-sized enterprises (SMEs) play a critical role. They provide a variety of economic contributions; income generation, the creation of new job opportunities, the introduction of innovation, and the promotion of competition are all examples of these. Despite their substantial contribution, SMEs in the food manufacturing sector in developing economies confront a variety of problems and constraints that prevent or limit their ability to maintain a sustained competitive advantage. Networking competency has been identified as one of the missing link to the sustainability of SMEs. The aim of this study was to determine the effect of network capabilities on the sustainability of SMEs in Kenya's food manufacturing enterprises. A cross-sectional approach and a descriptive survey design were utilised in this study. Quantitative primary data was obtained from 106 owners of 123 SMEs in the food and beverage sub-sector in Kenya registered by the Kenya Association of Manufacturers, yielding an 86 percent response rate. The research revealed that networking capabilities account for 6.9 percent of SMEs' sustainable competitive advantage, with each unit increase in networking capabilities improving the SCA of Kenyan SMEs by 0.306.
Effect of nasal irrigation with budesonide and normal saline on patients with chronic rhino-sinusitis surgery
Authors: Xu Chenjie , Shi Yi , Hu Weiqi , Zhu Yingchao 
Published: September 2024

Purpose: To investigate the therapeutic effect of budesonide nasal irrigation and saline irrigation in patients undergoing surgery for chronic rhinosinusitis (CRS).
Methods: One hundred patients scheduled for functional endoscopic sinus surgery (FESS) in Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, China were enrolled. The patients were divided into study and control groups comprising 50 cases each. The study group received postoperative budesonide irrigation while control group received normal saline irrigation after surgery. Post-operative symptoms, signs, and adverse reactions of the patients were compared.
Results: Five weeks post-operation, the visual analogue scale (VAS) scores of nasal congestion, nasal discharge, nasal itching, sneezing, nasal pain, and the score of nasal endoscopy one week and 4- weeks after operation were significantly lower compared to control (p < 0.05). There was no significant difference in nasal bleeding when the packing was removed between the two groups (p > 0.05) after surgery. Within the first week after surgery, there was no significant difference in occurrence of nasal malodor (p > 0.05).
Conclusion: Application of budesonide nasal irrigation alleviates post-operative symptoms, reduces inflammation and improves treatment outcomes. Further studies will be required to comprehensively investigate the dose effect of budesonide.
Krakowski ośrodek badań nad historią kultury na przełomie XIX i XX wieku
Authors: Stinia Maria 
Published: September 2024

Kształtowanie historii kultury jako samodzielnej dyscypliny naukowej w Krakowie odbywało się na przełomie XIX i XX wieku. Naukowcy ośrodka krakowskiego pozostawali w ścisłym związku z dorobkiem myśli europejskiej, lecz ze względu na specyficzną sytuację społeczeństwa polskiego pozbawionego własnej państwowości musieli określić własne cele. W środowiskach historyków i historyków literatury skupiono się na dokumentowaniu dorobku cywilizacyjnego w zakresie najistotniejszych wówczas kwestii, za jakie uznano potwierdzenie ścisłego związku kultury polskiej z kulturą europejską, przypomnienie najważniejszych osiągnięć w zakresie literatury oraz dziejów instytucji oświatowych, a zwłaszcza uniwersytetów. Koncentrowano się więc na dorobku okresu odrodzenia oraz oświecenia. Pojawiły się również oryginalne koncepcje dziejów cywilizacji autorstwa Feliksa Konecznego. W efekcie badań i interdyscyplinarnej współpracy Akademii Umiejętności oraz Uniwersytetu Jagiellońskiego udało się powołać na tej uczelni pierwszą na ziemiach polskich katedrę historii kultury.
“May our great Church grow and prosper — the Church United with the People and the People United with the Church!” Celebration of the 900th Anniversary of the Baptism of Rus in 1888 in the Russian Empire (Based on Materials from the Church Periodical Press)
Authors: Карпук Д.А. 
Published: September 2024

Празднование 900‑летия Крещения Руси в 1888 г. стало одним из самых массовых церковно-государственных празднеств за всю историю Российской империи. Главные торжества проходили в Киеве с участием митрополита Киевского и Галицкого Платона (Городецкого), обер-прокурора Св. Синода К. П. Победоносцева и других видных церковных и светских деятелей. Торжественные мероприятия 14 и 15 июля прошли в С.‑ Петербурге и Москве, а также во всех крупных городах. Праздничные богослужения, согласно указу Св. Синода, были совершены во всех соборах и храмах Русской Православной Церкви. Подготовка и сами торжества довольно подробно описывались на страницах церковной периодической печати. Краткому обзору ключевых публикаций посвящена данная статья.
The celebration of the 900th anniversary of the Baptism of Rus in 1888 became one of the most massive church-state celebrations in the entire history of the Russian Empire. The main festivities took place in Kiev with the participation of Metropolitan Platon (Gorodetsky) of Kiev and Galicia, Ober-Procurator of the Holy Synod K. P. Pobedonostsev, and other prominent church and secular figures. Solemn events on July 14 and 15 also occurred in St. Petersburg and Moscow, as well as in all major cities. According to the decree of the Holy Synod, festive services were held in all cathedrals and churches of the Russian Orthodox Church. The preparation and the celebrations themselves were described in detail on the pages of the church periodical press. This article provides a brief overview of key publications dedicated to this topic.
“I am given a special task in my future ministry — it’s missionary activity, which attracted me from the days of my youth …”: Bishop Neophyte’s (Slednikov) missionary activity among the Old Believers of the Vologda province
Authors: Зяблицкий О.Н. 
Published: September 2024

Статья посвящена одному из самых активных членов Вологодского братства во имя Всемилостивого Спаса — Николаю Николаевичу Следникову, впоследствии епископу Старобельскому Неофиту. По окончании Казанской духовной академии, подготавливавшей студентов к миссионерскому служению, Николай Следников в 1899 г. принял должность епархиального миссионера. На протяжении тринадцати лет, исполняя данное послушание, он не оставлял его даже после назначения на высокую должность настоятеля крупнейшего монастыря Вологодской епархии. Деятельность миссионера пришлась на время укрепления начал веротерпимости, в связи с чем анализируется миссионерское служение в епархии в контексте либерализации государственного законодательства о старообрядчестве. Особое внимание уделено роли епископа Вологодского Никона (Рождественского) в формировании личности миссионера и будущего иерарха.
This article is dedicated to one of the most active members of the Vologda Brotherhood in the name of the All-Merciful Savior — Nikolai Nikolaevich Slednikov, later Bishop Neophyte of Starobilsk. After graduating from the Kazan Theological Academy, which prepared students for missionary service, Nikolai Slednikov assumed the position of diocesan missionary in 1899. Fulfilling this assignment for thirteen years, he did not leave it even after being appointed to the high position of abbot at the largest monastery of the Vologda Diocese. The missionary’s activity came at a time of strengthening the principles of religious tolerance, in connection with which missionary service in the Diocese is analyzed in the context of state legislation’s liberalization on the issue of Old Believers. The article pays special attention to the role of Bishop Nikon (Rozhdestvensky) of Vologda in the formation of the missionary’s personality.
Campaign to confiscate church valuables and lawsuits against Orthodox clergy in 1922 as part of the final stage of the Russian Civil War
Authors: Петров И.В. 
Published: September 2024

1922 год для истории России ознаменовал окончание Гражданской войны и образование Советского Союза. Одним из последних, если не сказать последним, противников большевистской власти была некогда самая большая поместная Православная Церковь. Голод в Поволжье 1921–1922 гг. и его ужасающие последствия вылились в организованную советскими властями кампанию по изъятию церковных ценностей. Процесс изъятия вызвал далеко не однозначную реакцию среди верующих, часто становился причинами эксцессов и столкновений между представителями комиссий по изъятию и вооруженных красноармейцев, с одной стороны, и защитниками церкви — с другой. Наиболее жестокий оборот события приняли в Шуе, Москве и Петрограде. Итогом произошедших столкновений стали показательные судебные процессы, с помощью которых власти решили обнажить проблему и показать населению, кто не желает оказывать помощь голодающим. Однако, вместо ожидаемого эффекта они получили сопротивление и неприятие. Статья основана на архивном материале и периодической печати.
1922 for the history of Russia marked the end of the Civil War and the formation of the Soviet Union. One of the last, if not the last, opponents of the Bolshevik regime was once the largest Local Orthodox Church. Famine in the Volga region of 1921–1922 and its horrifying consequences resulted in a campaign organized by the Soviet authorities to seize church valuables. The process of seizure caused a far from unambiguous reaction among believers, often became the causes of excesses and clashes between representatives of the commissions for the seizure and armed Red Army soldiers on the one hand, and the defenders of the church on the other. The most cruel turn of events took place in Shuya, Moscow and Petrograd. The clashes resulted in show trials, with the help of which the authorities decided to expose the problem and show the population who does not want to help the hungry. However, instead of the expected effect, they received resistance and rejection. The article is based on archival material and periodicals.