bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model
Authors: Cheng N-T. , Guo A. , Cui Y-P. 
Published: June 2016

Objectives Recent studies have shown that systemic injection of rapamycin can prevent the development of osteoarthritis (OA)-like changes in human chondrocytes and reduce the severity of experimental OA. However, the systemic injection of rapamycin leads to many side effects. The purpose of this study was to determine the effects of intra-articular injection of Torin 1, which as a specific inhibitor of mTOR which can cause induction of autophagy, is similar to rapamycin, on articular cartilage degeneration in a rabbit osteoarthritis model and to investigate the mechanism of Torin 1’s effects on experimental OA. Methods Collagenase (type II) was injected twice into both knees of three-month-old rabbits to induce OA, combined with two intra–articular injections of Torin 1 (400 nM). Degeneration of articular cartilage was evaluated by histology using the Mankin scoring system at eight weeks after injection. Chondrocyte degeneration and autophagosomes were observed by transmission electron microscopy. Matrix metallopeptidase-13 (MMP-13) and vascular endothelial growth factor (VEGF) expression were analysed by quantitative RT-PCR (qPCR).Beclin-1 and light chain 3 (LC3) expression were examined by Western blotting. Results Intra-articular injection of Torin 1 significantly reduced degeneration of the articular cartilage after induction of OA. Autophagosomes andBeclin-1 and LC3 expression were increased in the chondrocytes from Torin 1-treated rabbits. Torin 1 treatment also reduced MMP-13 and VEGF expression at eight weeks after collagenase injection. Conclusion Our results demonstrate that intra-articular injection of Torin 1 reduces degeneration of articular cartilage in collagenase-induced OA, at least partially by autophagy activation, suggesting a novel therapeutic approach for preventing cartilage degeneration and treating OA. Cite this article: N-T. Cheng, A. Guo, Y-P. Cui. Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model. Bone Joint Res 2016;5:218–224. DOI: 10.1302/2046-3758.56.BJR-2015-0001.
Hongi, hangi, haka, moko: Language and the representation of Maori culture in contemporary mainstream travel guidebooks
Authors: De Marco Alessandra 
Published: June 2016

Abstract
Tourist texts, such as brochures or guidebooks, are among the first sources of encounter between tourists and destination people. Indeed, such texts provide tourists with a ‘cognitive framework’ (Bhattacharya 1997: 372) for interpreting a destination and its cultures, and language in travel writing is paramount for negotiating between different cultures and meanings. Guidebooks should thus be read critically in order to assess the cultural images they construct to promote a specific destination, and the language they use to create them. This article offers a linguistic and discursive analysis of how mainstream travel guidebooks of Aotearoa New Zealand in English (i.e., Lonely Planet, Rough Guide, National Geographic Traveler and the DK Eyewitness Travel Guide) represent Maori culture. Specifically, the sections on the culture of tangata whenua (the people of the land/Maori people) in these guidebooks will be studied to determine which aspects of Maori culture are used to depict the Maori people of Aotearoa New Zealand and how the language of tourism shapes such descriptions. The title of this article refers to the four words in te reo Maori (Maori language) that are most commonly associated with Maori culture in tourist texts. The aim of the article is to determine whether these descriptions offer an exoticized version of Maori culture, or whether they effectively engage with its actuality and complexity. Following a transdisciplinary approach that bridges sociolinguistics and tourism studies, the article seeks to present a case study that demonstrates how fruitfully linguistic analysis can be used in the discussion of the production and dissemination of the tourist image of Maori people in Aotearoa New Zealand from an Indigenous tourism studies perspective.
Lady Emma Hamilton’s Attitudes Renewed: Art gallery performance project
Authors: Wallis Jillian 
Published: June 2016

Abstract
What happens when a contemporary, live art performance is designed and staged for a Renaissance building that is an international tourist attraction in its own right, and displays an outstanding fine art collection in its rooms and corridors? In 2014 I helped to create a theatre performance at The Queen’s House art gallery in Greenwich and in so doing attempted something fairly radical for a museum setting. Lady Emma Hamilton’s Attitudes Renewed was a collaboration between Akleriah, a visually experimental performance collective, myself as a theatre director and film-maker Jason Wen. The iconic Emma Hamilton was arguably the first female performance artist and the piece was commissioned to tie in with a display of eighteenth-century engravings and paintings in which she features. The flamboyant costume design and choreographic nature of Akleriah’s work instigates immediate audience attention in non-theatre spaces but the art gallery setting for this performance made additional demands. This article considers the negotiation of that space as a venue, navigates the production process from conception to realization, and asks if and how the expectations of the gallery Programmer, and the 350 viewers who saw the piece, were met. The research and rehearsal period is critiqued to track the re-imagining of actual historical characters with an inventive contemporary lens, using intersection between live and filmed images, and fragments of text. The semilit location of the performance, its relationship to the pictures on the walls and the recurring frequency of the fifteen minutes duration are key issues. An outcome of the event notices how the close proximity and presence of the semi-transitory audience needed a particular theatrical complicity, a trust within the space. The film projection enhanced the fluidity of the piece, with its shifts in reality and perspective. Feedback included ‘ghostlike ... beautiful ... intriguing’, bringing alive characters and space.
The sonorous void: Acoustic stages and sound play in Eugene Ionesco’s Rhinoceros
Authors: Dima Vlad 
Published: June 2016

Abstract
Among the many conflicts pervading Eugene Ionesco’s influential play Rhinoceros (1961) one stands out as a dominant means to spring the story forward. It is not a subtle dramatic device, and yet it has not gotten much attention from critics and theorists. In this particular play, more so than elsewhere in Ionesco’s oeuvre and in the theatre of the absurd in general, there is an insistence on creating a conflict between what one sees, hears and imagines. Several oscillations and leaps that occur between exterior and interior spaces highlight this narrative conflict. The sounds and noises specified by the didascalia help the reader navigate the story while occasionally and playfully taking the reader completely out of the diegetic space. New, imaginary acoustic spaces and stages emerge and fill the void around the actual stage, as at the centre of it all the main character, Bérenger, functions as a kind of aural shape-shifter, capable of moving between different levels of interiority and exteriority through sound. The purpose of this article then is to explore the role of sound and sound directions in Rhinoceros and to establish that a new type of space – an imaginary acoustic space – is created. The article also indexes the elements of play and playfulness that help generate a variety of diegetical and extradiegetical spaces, from among which the aural component emerges as a crucial means to support the narrative.
Uma aplicação prática de gestão do conhecimento e simulação na resolução de problemas complexos empresariais
Authors: Zambon Antonio Carlos , Baioco Gisele Busichia , Chiste Cristiano , Vasques Dildre Georgiana 
Published: June 2016

Este trabalho apresenta um estudo de caso em uma pequena empresa do setor de máquinas e equipamentos industriais. Essa empresa mostrava problemas relacionados com a incapacidade de entregar as encomendas feitas por seus clientes dentro do prazo acordado, além de diferenças nos métodos de gestão utilizados pelos seus gestores. A fim de analisar e resolver esses problemas, situados na fronteira entre problemas estruturados e não estruturados, inicialmente modelamos o conhecimento dos gestores por meio de diagramas conceituais estendidos apoiados por um processo cognitivo. Posteriormente, simulamos o modelo obtido, usando Dinâmica de Sistemas. O modelo obtido promoveu a aprendizagem em grupo e apoiou estratégias de atendimento por meio de simulação. A modelagem e a simulação desencadearam mudanças no comportamento gerencial e melhoria do clima organizacional. As mudanças comportamentais também resolveram o problema das entregas.
Fatores críticos para o sucesso do seis sigma: um levantamento do impacto do tempo de empresa e do treinamento na indústria alimentícia
Authors: Drohomeretski Everton , Gouvea da Costa Sergio E. , Pinheiro de Lima Edson , Da Silva Wesley Vieira 
Published: June 2016

A metodologia Seis Sigma apresenta um crescente interesse por parte de empresas dos diversos setores. Isso se dá, principalmente, em virtude dos seus resultados atrelados à redução de custos, aumento da confiabilidade e do padrão de qualidade. Porém, para que os resultados do Seis Sigma sejam alcançados e sustentados, faz-se necessária a gestão de alguns fatores críticos de sucesso (FCS) do Seis Sigma. O presente artigo tem por objetivo investigar os FCS para implantação da metodologia Seis Sigma e identificar quanto o tempo de empresa e o nível de formação Seis Sigma influenciam nos FCS. Para atingir o objetivo proposto foi realizada uma pesquisa de campo com 80 respondentes, com formação em Seis Sigma, de uma indústria alimentícia de grande porte localizada no Sul do Brasil. Os dados foram analisados por meio de estatística descritiva, teste de correlação, análise multivariada por meio da análise fatorial e análise de regressão múltipla. Com base na amostra pesquisada, os resultados evidenciaram que os FCS estudados apresentam uma contribuição significativa para o sucesso do programa Seis Sigma. Além disso, pode-se verificar que o tempo de empresa dos funcionários apresenta correlação positiva para o constructo treinamento, e o nível de formação em Seis Sigma apresenta correlação negativa com os constructos Treinamento, Comunicação e Revisão e Operação.
“Cash Is Better than Tenure”: (De)Constructing the “Posthistorical University” in James Hynes’s Gothic Academic Satire The Lecturer’s Tale
Authors: Andreescu Raluca 
Published: June 2016

Abstract
This article analyzes the manner in which James Hynes’s novel The Lecturer’s Tale (2001) can be read as a satire of what Bill Readings identified in his influential The University in Ruins (1996) as the “posthistorical university.” I argue that, in the contemporary context in which higher education establishments are becoming more like corporations and the idea of culture is replaced by the “discourse of excellence,” Hynes’s novel offers an insightful discussion of universities’ negotiation of the Scylla of the pursuit of profit and the Charybdis of self-absorbed literary theorizing and its association with political correctness, the exploitation of junior and non-tenured faculty, and the quest for academic stardom. At the same time, I discuss the way in which the Gothic elements that permeate the novel fittingly double and deepen the critique of contemporary educational establishments and professors.
In Pursuit of Happiness: Escape, Change, and Return in Contemporary Academic Novels, Or Why I Read Campus Novels, But Possibly Shouldn’t
Authors: Łysik Marta 
Published: June 2016

Abstract
In this personal essay, the author compares her academic experiences to those of characters in the campus novels she enjoys reading. The novels she discusses here share a thematic concern with happiness and all seem to indicate that professional fulfillment and academic status are not sufficient in order to achieve that state.
Hölder regularity at the boundary of two-dimensional sliding almost minimal sets
Authors: Fang Yangqin 
Published: June 2016

Abstract
In [15], Jean Taylor proved a regularity theorem
away from the boundary for Almgren almost minimal sets of dimension 2 in

ℝ
3

{\mathbb{R}^{3}}

. It is quite important for understanding the soap films and
the solutions of Plateau’s problem away from boundary. In this paper, we
will give a regularity result on the boundary for two-dimensional sliding
almost minimal sets in

ℝ
3

{\mathbb{R}^{3}}

.
A real health problem of our days: Colorectal Cancer
Authors: Gheorghita Raluca-Andreea , Ulmeanu Victoria , Tuta Liliana , Nedelcu Cristina , Nitu T.S. , Scrinic Olesea , Oanta M. , Ilie Mihaela , Muflic L. 
Published: June 2016

Abstract
Colorectal cancer is one of the major mortality causes in the world, with an increased frequency in western countries, which are better developed economically. Romanian statistics show that the frequency of this type of cancer is increasing rapidly. In the year 2000, all over the world there were approximately 1 million new cases of colorectal cancer, and over 500 thousands deaths, thus affecting 1 from 20 inhabitants from the developed countries and being the second main cancer death cause, at both sexes in Europe. In Romania, incidence and mortality have doubled in the last 20 years, reaching a 17.74/100000 inhabitants incidence in the year 2000. Both for men and women, this disease is on the 3rd place in Romania, after bronhopulmonary cancer and gastric (for men) and breast and uterus cancer, respectively.
This paper has as purpose obtaining data about the frequency of colorectal cancer in recent years, and the repartition of this data on years, sex, age, environment, complications and other particularities. To reach this purpose we have done a retrospective study on patients that were admitted during 2010-2014 in the surgical clinic, medical clinic and oncology section from the Constanta Emergency County hospital, with colorectal neoplasm as a diagnosis.
Tumoral retroperitoneal masses and their impact to renal function
Authors: Azis Olgun , Fasie Dragos , Tuta Liliana Ana , Daba Lavinia , Voinea Felix 
Published: June 2016

Abstract
Retroperitoneal tumors, either benign or malignant, usually cause problems both for an accurate diagnosis and for therapeutic approach, due to their reduce incidence, late presentation and anatomical location, in the neighborhood of vital structures from the retroperitoneal space. Materials and methods: Aim of study was to search correlations between, gender, age, and histo-pathological type of retroperitoneal tumors, as well as their impact upon renal function. Results: Sarcomas represented about 30% of retroperitoneal tumors. The most frequent benign retroperitoneal tumors included: neurogenic tumors, paragangliomas, renal angiomyolipomas and benign retroperitoneal lipomas. Renal function was altered in about 55% of the patients, and postsurgical mortality was 8.73%.
Using Modern Diagnostic Methods for Technological Discipline Assessment of Maize Silage
Authors: Gálik Roman , Boďo Štefan , Staroňová Lenka 
Published: June 2016

Abstract
The paper focuses on the analysis of compliance with the technological discipline in silage quality assessment based on sampling the silage wall using thermal imaging and penetrometer method for silage compaction. Experimental measurements were done in a selected company, which has built a silage trough with a capacity of 6,624 m3, in which the maize (hybrid KWS – KALIFF FAO 440) with a 36% solids content was ensiled. A thermal camera ThermoPro TM TP8S IR and cone penetrometer Eijkelkamp were used for measurements. The results obtained suggest that also undesirable heating was found in the sampling area, since the maximum temperature at some places in the depth of 0.5 m reached a temperature of 36.4 °C. According to regression and correlation analysis, we found direct linear relationship between penetration resistance and penetration depth in a 6 m and 1.5 m height (R = 0.938 respectively R = 0.970).
Variability of geostrophic airflow over Poland, 1951-2014
Authors: Marosz Michał 
Published: June 2016

Abstract
The paper presents the analysis of the anemological conditions variability over Poland with the usage of geostrophic wind vector as an objective (and homogenous) information concerning the airflow over the area of research. The geostrophic wind vector components are calculated using SLP and air temperature (at sigma 995 level) at selected gridpoints which were subsequently interpolated to a central point thus describing the average flow over the research area. The data originated from NCEP/NCAR Reanalysis and its temporal range was 1951-2014. The analysis covers statistical characteristics of the overall annual cycle as well as trend analysis of the airflow features over Poland: geostrophic wind vector module (V), and its zonal (u) and meridional (v) components. Aside from general statistical characteristics for averages and extremes (quantiles 10% and 90%) GEV distribution was fitted to maximum annual/monthly geostrophic wind speed values which allowed the estimation of return levels for selected return periods. For the period 1951-2014 average geostrophic wind velocity over Poland equals 7.4 ms−1 and the 99% quantile exceeds 21 ms−1. Maximum speed ever recorded equalled 37.6 ms−1. Geostrophic wind vector module (V) and its components (u, v) exhibit clear annual cycle with the highest V values in winter. Positive (westerly) u values dominate in the colder part of the year. In spring the dominance of eastern advection appears and in summer the prevalence of westerly flow is only minimal. There exists a distinctive variability of decadal directional structure and this is clearly visible in the substantial increase in the share of western sector frequencies in 1981-1990 and following decade. Monthly V averages do not exhibit (except October) statistically significant trends whereas in spring and summer months as well as for annual averages of u component trend is significant. There are virtually no significant changes in the v values. GEV analysis allowed the year to be divided into two parts. Warm one with relatively low return levels – for many months not exceeding 20 ms−1 even for 50y return period. On the other hand winter months return level values exceed 30 ms−1 even for relatively short return periods (20y) with upper estimates for 100y return period closing to 40 ms−1.
The impact of solar radiation on the temperature of the exposed rocks of the karst canyon (the Kraków-Częstochowa Upland, Poland)
Authors: Caputa Zbigniew Andrzej 
Published: June 2016

Abstract
The paper presents results of the research on the impact of solar radiation on the formation of the thermal conditions of the exposed rock surfaces of the Kraków-Częstochowa Upland. The research comprised the structure of the radiation balance of the active surface of the bottom of the canyon, the temperature of the surface and the layer at the depth of −5 cm in limestone rock on the southern wall of the canyon. The tests were performed in various types of weather. The strongest mesoclimate contrasts were observed in the radiation type of weather: differences in insolation and in the balance of radiation, thermal differences and variations within the heat flux in the rock. The longwave stream of radiation which was emitted by the heated rocks exerted an impact on the microclimate conditions and on the radiation balance at the bottom of the canyon during the night. A diverse relief of the terrain constituted a local factor differentiating the radiation balance and the distribution of the rock temperature. The quantitatively determined structure of the radiation balance and the thermal contrasts of the canyon, particularly of the rock surfaces, point to the importance of the relief in shaping the mesoclimate of even small karst areas. These characteristics determine the heat flux in the rock, weathering processes and others. The mesoclimate and microclimate of the rocks affect the biodiversity of the rock surfaces of the Kraków-Częstochowa Upland. In addition, they shape the ecotopy of the karst canyon, among others – the vegetation on the limestone rocks.
Contemporary changes of thermal conditions in Poland, 1951-2015
Authors: Owczarek Małgorzata , Filipiak Janusz 
Published: June 2016

Abstract
The main subject of the research whose outcomes are presented in this paper is the spatial and temporal variability of thermal conditions in Poland during the period from 1951 to 2015. The analysis revealed the occurrence of symptoms indicating a systematic and sustained warming. Significant growth is observed in mean and extreme temperatures and their extreme percentiles, as well as in annual number of hot days, warm waves and their duration. In turn, downward trends are noted in series of the annual number of frost days, as well as in the number of cold waves and their duration. The results obtained confirm the thermal pattern determined for the whole region, especially for the southern part of the Baltic Sea basin.
Ground thermal regime on the Kaffiøyra Plain (NW Spitsbergen) in the period from 1 September 2012 to 31 August 2014
Authors: Araźny Andrzej , Przybylak Rajmund , Kejna Marek 
Published: June 2016

Abstract
The article presents the results of ground temperature measurements taken at 1 cm to 100 cm below ground level on the Kaffiøyra Plain (NW Spitsbergen) from 1 September 2012 to 31 August 2014. Observations of thermal conditions were carried out at three sites located in characteristic polar ecotopes: on a beach, in tundra and on a moraine. The results of ground temperature measurements for the Kaffiøyra Plain were compared to the observations of weather conditions at the nearby meteorological station in Ny-Ålesund. The variability of ground temperature was analysed in annual, seasonal and diurnal courses. These reflected the prevailing meteorological conditions at the time. Substantial differences in ground thermal conditions were found between the ecotopes, which was due to the morphological diversity of the ground, its moisture content, vegetation and snow cover, as well as the depth of the permafrost.
Effect of North Atlantic Oscillation on the hydrological conditions of Lake Morskie Oko (Carphatian Mountains)
Authors: Wrzesiński Dariusz , Choiński Adam , Ptak Mariusz 
Published: June 2016

Abstract
The paper presents the effect of North Atlantic Oscillation of macroscale atmospheric circulation (NAO) on the hydrological conditions of Lake Morskie Oko located at an altitude of 1392.8 m a.s.l. in the highest range of the Carpathians. The paper applied detailed hydrometric information from the years 1971-2010 concerning water level fluctuations, water temperature, terms of the commencement and end of ice phenomena and ice cover, as well as meteorological data concerning air temperature and atmospheric precipitation, and monthly and seasonal NAO indices. The performed analysis suggests that the majority of analysed hydrological characteristics of Lake Morskie Oko was not prone to variability of NAO intensity in its various phases. The situation results from the local conditions, particularly responsible for the course of processes and phenomena in Lake Morskie Oko, simultaneously obscuring the effect of macroscale factors.