bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing Successful Pregnancies in Patients with Chronic Intestinal Failure on Home Parenteral Nutrition: Experience from a UK National Intestinal Failure Unit
Authors: Bond Ashley , Vasant Dipesh H. , Gashau Wadiamu , Abraham Arun , Teubner Antje , Farrer Kristine , Leahy Gavin , Lal Simon 
Published: November 2017

Background & Aim: There are minimal reports of pregnancy in the chronic intestinal failure (CIF)/ home parenteral nutrition (HPN) population, with some concern relating to the risk associated with such pregnancies. The aim of this retrospective observational study was to evaluate pregnancy experience and outcomes in patients with CIF requiring HPN in a national UK CIF referral centre.Method: All known pregnancies in patients treated with HPN for CIF between 1982 and 2016 were identified retrospectively from a prospectively maintained database. Maternal and foetal outcomes were collated, along with PN requirements before and during pregnancy.Results: There were 5 pregnancies in 5 mothers in our cohort consisting of over 700 patients, males and females. The median age at conception was 28 years (range 24-33 years). The median duration on HPN prior to pregnancy was 26 months (range 4-85 months). One patient had Crohn’s disease, another had pan-enteric dysmotility and the other three patients had ischaemic complications leading to short bowel syndrome (SBS). All mothers were intensively monitored in an obstetric clinic and a dedicated CIF multi-disciplinary clinic throughout pregnancy. There were 2/5 preterm deliveries. One of the preterm deliveries was associated with spontaneous labour and the other had a planned induction as a result of maternal clinical need. Neonatal complications were seen in both prenates. There were no recorded maternal catheter related line infections during the 5 pregnancies.Conclusion: Successful pregnancy whilst receiving HPN is feasible but requires close, intensive monitoring and dedicated optimisation of PN in order to minimise maternal and foetal complications. All women of child-bearing age on HPN should be counselled about pregnancy.Abbreviations: ALP: alkaline phosphatase; ALT: alanine transaminase; CIF: chronic intestinal failure; HPN: home parenteral nutrition; IBD: inflammatory bowel disease; IF: intestinal failure; IFALD: Intestinal Failure associated liver disease; LFT: liver function test; PN: parenteral nutrition; RDA: Recommended daily allowance; SBS: short bowel syndrome; TPN: total parenteral nutrition.
Radium-223 Safety, Efficacy, and Concurrent Use with Abiraterone or Enzalutamide: First U.S. Experience from an Expanded Access Program
Authors: Sartor Oliver , Vogelzang Nicholas J. , Sweeney Christopher , Fernandez Daniel C. , Almeida Fabio , Iagaru Andrei , Brown Alan , Smith Matthew R. , Agrawal Manish , Dicker Adam P. , Garcia Jorge A. , Lutzky Jose , Wong Yu-Ning , Petrenciuc Oana , Gratt Jeremy , Shore Neal D. , Morris Michael J. ,   for the U.S. Expanded Access Program Investigators
Published: November 2017

Abstract

Background
In the phase III ALSYMPCA trial, metastatic castration-resistant prostate cancer (mCRPC) patients had few prior life-prolonging therapies. Following ALSYMPCA, which demonstrated radium-223 survival benefit, and before radium-223 U.S. commercial availability, an expanded access program (EAP) providing early-access radium-223 allowed life-prolonging therapies in current use.

Subjects, Materials, and Methods
This phase II, open-label, single-arm, multicenter U.S. EAP (NCT01516762) enrolled patients with symptomatic mCRPC, ≥2 bone metastases, and no lung, liver, or brain metastases. Patients received radium-223 55 kBq/kg intravenously every 4 weeks × 6. Primary outcomes were acute and long-term safety. Additional analyses were done by number of radium-223 injections, and prior or concomitant abiraterone or enzalutamide use.

Results
Of 252 patients, 184 received radium-223: 165/184 (90%) had Eastern Cooperative Oncology Group (ECOG) performance status 0–1; 183 (99%) had prior systemic anticancer therapy. Treatment-related adverse events occurred in 93/184 (51%) patients during treatment and 11 (6%) during follow-up. Median overall survival was 17 months, with 134/184 (73%) patients censored because of short follow-up due to radium-223 approval. In post hoc analyses, patients with ≥3 prior anticancer medications, baseline ECOG performance status ≥2, and lower baseline hemoglobin were less likely to receive 5–6 radium-223 injections and unlikely to benefit from radium-223. Radium-223 was well tolerated regardless of concurrent or prior abiraterone or enzalutamide.

Conclusion
Radium-223 was well tolerated, with no new safety concerns; safety was maintained with abiraterone or enzalutamide. Patients with more advanced disease were less likely to benefit from radium-223. Clinicians should consider baseline characteristics and therapy sequence for greatest clinical value.

Implications for Practice
In this phase II U.S. expanded access program, radium-223 was well tolerated, with a median overall survival of 17 months in metastatic castration-resistant prostate cancer patients. In post hoc analyses, radium-223 was safe regardless of concurrent abiraterone or enzalutamide, and median overall survival appeared longer when radium-223 was used earlier in patients with less prior treatment. Patients with more advanced disease were less likely to benefit from radium-223. Clinicians should consider baseline clinical characteristics and therapy sequence to provide the greatest clinical value to patients.
influence of collaboration in research priorities: The SADC Case
Authors: Pouris Anastassios 
Published: November 2017

This study was aimed at providing evidence of the effects of collaboration among unequal partners on their research priorities. Co-authorship patterns were investigated among South African authors publishing with authors of other countries in the region, with and without other non-African co-authors. It was identified that the non-African collaborators have a high impact on the quantity of co-authored publications and on the research disciplines in which co-authored research is undertaken. The findings raise a number of policy questions.

Significance:

The findings make profound that African countries should prioritise and engage their limited resources in areas of national priorities.
Screening for gestational diabetes: evaluation of prevalence in age-stratified subgroups at Central hospital Warri Nigeria
Authors: M. I. Orru , E. U. Nwose , E. U. Nwose , P. T. Bwititi , E. U. Nwose , E. O. Igumbor , P. T. Bwititi , P. T. Bwititi , E. O. Igumbor , E. O. Igumbor 
Published: November 2017

Background: The prevalence of gestational diabetes depends on the method of diagnosis as well as ethnic background. Maternal age has also been identified as a factor, but has not been given much attention. The notion of gestational prediabetes has also speculated, but is equally yet to be a focus in discussion. Aim: This work aimed at evaluating the screening for gestational diabetes in Central Hospital, Warri; to determine prevalence of gestational diabetes in the general population and in stratified age groups. The other objective was to investigate the effectiveness and use of the methods of diagnosis. Materials and Methods: This was a retrospective review of laboratory data of de-identified antenatal patients. Hospital records of gestational diabetes from 2013 to 2015 were obtained from the Central Hospital, Warri. Data collected included age of the de-identified patients, blood glucose results and whether the test was fasting or random. Other information was the month/year of test. A total of 3 589 results were analyzed. Results: Averaged prevalence of 5.85% is identified. Fasting blood sugar (FBS) measurement was used more and it also identified more positives (9%) compared to random blood sugar (<2%). On a dichotomous age group, prevalence of gestational diabetes appeared low in women below 25 years compared to those ≥26 years old. In a more stratification of age groups, potential antepartum prediabetes in pregnancy was lower in women above 40 years old relative to the younger age subpopulations (p < 0.000001). No significant variation was observed in level of usage of either method between months/years. Conclusion: There is an ongoing good practice of using affordable screening test, which is FBS. The significant finding was that there may be up to 9% prevalence of GDM and that this number may erroneously be lower if random blood glucose measurement is used. Another worthy observation was that the prevalence in stratified age groups was non-directional, especially as prediabetes appears higher in the younger age subpopulation.
Effect of hypothermia for perinatal asphyxia on childhood outcomes
Authors: Jose Santhosh , K. Mohamad Ismael 
Published: November 2017

Background: Perinatal asphyxia, neonatal asphyxia or birth asphyxia is the medical condition resulting from deprivation of oxygen to a new born infant that lasts long enough during the birth process to cause physical harm, usually to the brain. This study was performed to evaluate study population who were 6 to 8 years of age to determine whether the application of moderate hypothermia after perinatal asphyxia is associated with long term benefits.Methods: This study was a randomised, controlled trials which consisted of infants who were admitted with moderate and severe encephalopathy within 6 hours after birth after an acute perinatal event, with acidosis or resuscitation. Infants were assigned to undergo whole body hypothermia at 33ºC for 72 hours or to undergo usual care randomly.Results: All maternal baseline characteristics and Neonatal characteristics are non significant in both groups. APGAR score ≤5 is significant at 10mins in comparison. cerebral palsy were 18% and 25%, respectively, the rates of blindness were 1% and 4% the rates of hearing impairment (requiring aids) were 5.4% and 12.8%. There were no significant between-group differences in the level of disability among all survivors or in motor function among the 45 nondisabled children. Among children who had moderate or severe disability at 18 months, the corresponding rates at 6 to 7 years of age were 88% in the hypothermia group and 95% in the control group. All the children who had moderate-to-severe cerebral palsy at 18 months continued to be affected at 6 to 7 years in both groups. There was no significant between-group difference with respect to IQ scores that were measured on a continuous scale and other scores, with the exception of 1 of the 11 scores compared (attention and executive function, P=0.03). There were also no significant differences between groups in mean scores on the index of health care status derived from parental assessments or in parental scores for children’s strengths and difficulties and ADHD The mean difference in the academic achievement score favored the hypothermia group but was not significant.Conclusions: Moderate hypothermia after perinatal asphyxia resulted in improved neurocognitive outcomes in middle childhood.
Pengaruh Zikir al-Ma’tsurat dan Terjemahannya Terhadap Penurunan Kecemasan Siswa Menghadapi Ujian Nasional
Authors: Jannah Nur 
Published: November 2017

The problems most often experienced by students when facing the National Exam is anxiety problems. Anxiety arises because students are burdened by thoughts and shadows of possibilities that occur when failing in the National Exam. Excessive anxiety will cause students not to focus on the National Exam. One way that can be done to provide peace of mind in the Islamic view is with dhikr. In contrast to most schools, SMPIT Ukhuwah Banjarmasin not only prepares students in the outer field such as additional subjects are tested, but the school also prepares the spiritual condition of students by giving the program of recitation of al-Ma’tsurat recitation that is read every afternoon. But the recitation of the dhikr is not with the translation. The reading of al-Ma’tsurat dhikr with its translation will invite the students to be more solemn and understand the content contained in the recitation of the dhikr. This study aims to determine the level of student anxiety and find out whether the dhikr al-Ma’tsurat and its translation have an effect on the decreasing anxiety of students facing the National Exam at SMPIT Ukhuwah Banjarmasin.This research is experimental research and data is presented with quantitative approach. Variable in this research there are 2 that dhikr al-Ma’tsurat and translation (X) and anxiety (Y). While the design of this study using the design pretest and posttest one group. Data collection tools in the form of anxiety scale The sampling technique used is purposive sampling, with the number of subjects as many as 7 students. Data analysis using t-test.The results of quantitative data indicate a decrease in anxiety between before the intervention (pretest) and after intervention (postest) is done, the scoring of the anxiety category from high to medium and low anxiety categories. And the decline of a large minimum value of 32.00 and the maximum value of 24.00, and the mean value of 24.7147. The result of the normality prerequisite test is p> 0,05 indicating that the data distribution at initial and final test is normal. The result of t-test is obtained t value = 11,068 and p = 0,000, p <0,01, meaning dhikr al-Ma’tsurat and its translation can influence decreasing anxiety of student facing National Exam at SMPIT Ukhuwah Banjarmasin.
Website usability evaluation with quickly applicable guidelines: An assessment of a government website
Authors: Tekmen Fatih , Tanriover Ozgun 
Published: November 2017

In this paper, an initial set of guidelines, rated as highly important by experts, is assessed in order to deduce a subset of quickly applicable ones. The widely accepted guidelines published by the U.S. Department of Health and Human Services is considered as an initial superset. Then an evaluation of a governmental website is done with the established subset and findings of the application process are discussed. In order to quickly improve the usability of websites in terms of design and aesthetics, quickly applicable guidelines may be helpful.
Keywords: Usability, usability guidelines, quickly applicable usability guidelines.
Enhancement of power flow using FACTS systems
Authors: Hocine Sekhane , Djamel Labed 
Published: November 2017

In this paper, both standard IEEE test systems 57-bus and Algerian 59-bus are considered. To enhance the power flow of these two considerable networks in terms of voltage profile and reduce the real and reactive total transmission losses, the inclusion of flexible alternating current transmission systems (FACTS) devices is one of the best solutions. For this, a static synchronous compensator (STATCOM) is proposed. Our code is written in the MATLAB computing environment, based on finding the weakest buses in the network, and placing one or two STATCOMs in an appropriate place; in the next step, there would be recalculation of the power flow again. The results of power flow compared with the popular MATPOWER software environment show the exactitude of our code calculation, and the enhancement of voltage profile, especially in buses where STATCOM is placed. Furthermore, the reduction of real and reactive losses shows the effectiveness of the FACTS device proposed.
Keywords: FACTS, STATCOM, MATLAB, MATPOWER.
Posterior reversible encephalopathy syndrome (PRES), pre‐eclampsia and emergency caesarean section
Authors: Cuell James , Marriott Joanna , Greenwood Jaime 
Published: November 2017

SummaryPosterior reversible encephalopathy syndrome (PRES) is a neurotoxic state with numerous clinical signs that may evolve rapidly and persist for weeks [1]. Diagnosis is confirmed with characteristic vasogenic cerebral oedema on cranial MRI [2].Hypertension in pregnancy, notably pre‐eclampsia and eclampsia are a major contributor to maternal mortality and morbidity [3]. The condition of PRES is often, but not always, associated with hypertension, yet it is not commonly within the list of differential diagnoses for hypertensive patients in pregnancy [4].We describe the case of a 25‐year‐old female patient presenting at term, requiring an emergency caesarean section under spinal anaesthesia that was converted to a general anaesthetic following an acute, sudden onset headache. She had no maternal hypertension or pre‐eclampsia and no relevant past medical history. After a subsequent uneventful post‐partum period she was discharged home, but was readmitted to hospital a few days later following a seizure and was subsequently diagnosed with PRES.
The challenge of effective policy implementation in Nigerian urban water utilities
Authors: Imonikhe O. M. , Moodley K. 
Published: November 2017

AbstractThe effectiveness of policy implementation is rapidly becoming a widely researched area in the water sector. Previously, most studies focused mainly on developing technical innovations for delivering sustainable water services and little attention was given to subject areas such as governance, policy implementation, and legislation. Now, water professionals and policy makers are beginning to recognise that efficient services occur when social, political, economic, environmental and technical issues are taken into consideration; hence, subject areas like policy implementation have started receiving attention as well. Thus, many nations such as the UK, Australia, and the USA are constantly aiming to establish best institutional practices for their water sector, while countries such as Nigeria are yet to establish effective policy implementation processes. This research examines the challenge of effective policy implementation in Nigerian urban water utilities. The research showed that policies and legislation developed were of commendable standards, but the implementation process was predominantly hindered by five factors. Hence, these factors will need to be managed actively if the Nigerian urban sector wishes to achieve the intended results from water legislation and policies.
Fe3O4-CS-L: a magnetic core-shell nano adsorbent for highly efficient methyl orange adsorption
Authors: Guo Shuangzhen , Zhang Jian , Li Xianlong , Zhang Fan , Zhu Xixi 
Published: November 2017

Abstract
A novel core-shell bio-adsorbent was fabricated by using biological materials for removing methyl orange (MO) from aqueous solution. The structure characteristics results of scanning electron microscopy (SEM), Fourier transform infrared spectrometry (FT-IR), thermo-gravimetric analysis (TGA), vibrating sample magnetometer (VSM), and Brunauer–Emmett–Teller (BET) shows that Fe3O4-CS-L has been successfully prepared. The effects of contact time, pH, temperature and initial concentration were explored. The results suggested pH was a negligible factor in adsorption progress. Kinetic studies showed that the experiment data followed pseudo-second-order model. Boyd mode suggested that external mass transfer showed a rather weak rate control for MO adsorption onto Fe3O4-CS-L. Equilibrium studies showed that isotherm data were the best described by Langmuir model. The maximum adsorption capacity of MO estimated to be 338.98 mg/g at 298 K. Moreover, the adsorption capacity of Fe3O4-CS-L can keep about 74% in the fifth adsorption–regeneration cycle. Thus, the Fe3O4-CS-L could be a kind of promising material for removing MO from wastewater.
La geografía de las oportunidades. El caso de las sedes de las universidades autónomas en municipios con poca oferta de educación superior
Authors: Mejía-Pérez Gustavo , Worthman Shaye S. 
Published: November 2017

Una de las estrategias generadas por el gobierno, para aumentar la oferta y cobertura de educación superior (ES) en México, ha sido la desconcentración de las universidades autónomas (UA). Para conocer el panorama de los procesos de desconcentración de las UA se generó una base de datos con información de las páginas web de las universidades y el Anuario Estadístico 2014-2015, así como datos sociodemográficos de los municipios sede, disponibles en las bases del Consejo Nacional de Población, el Instituto Nacional de Estadística y Geografía y la Secretaría de Educación Pública. En los resultados se muestra un panorama nacional de la ampliación de la oferta de ES, a través de las sedes desconcentradas de las UA. Además, se analizan 36 casos en los que las sedes de las UA son la única opción para ingresar a la ES. El análisis de la información muestra que, en los municipios con poca oferta de ES, las sedes benefician a jóvenes de municipios mayormente agrícolas y con bajos niveles de escolaridad; sin embargo, los datos sugieren que estas sedes operan por debajo de su capacidad y que tienen dificultades para asegurar la permanencia de los alumnos y la conclusión exitosa de sus estudios.
Comparación de perfiles de ansiedad matemática entre estudiantes mexicanos y estudiantes alemanes
Authors: Eccius-Wellmann Cristina , Lara-Barragán Antonio G. , Martschink Bastian , Freitag Stefan 
Published: November 2017

Se determinan los perfiles de ansiedad matemática de estudiantes mexicanos y estudiantes alemanes por medio de la aplicación de un cuestionario desarrollado ex profeso. La ansiedad matemática se define en términos de tres descriptores: creencias, actitudes y emociones. Los autores definen un Índice de Ansiedad Matemática, al aplicarlo encuentran que los estudiantes alemanes presentan un valor mayor de dicho Índice, lo que significa que tienen una mayor nivel de ansiedad matemática. Las diferencias en los valores del Índice de Ansiedad Matemática se interpretan en términos de diferencias culturales. La interpretación parece ser consistente con las diferencias culturales y se ajusta a los resultados obtenidos.
El desarrollo del pensamiento crítico en estudiantes universitarios por medio del aprendizaje basado en problemas
Authors: Núñez-López Susana , Ávila-Palet José-Enrique , Olivares-Olivares Silvia-Lizett 
Published: November 2017

La educación basada en competencias busca el desarrollo de habilidades cognitivas que permiten al estudiante generar un pensamiento crítico que se traduce en la capacidad del estudiante para resolver problemas dentro y fuera del aula. El propósito de este estudio fue encontrar el beneficio del Aprendizaje Basado en Problemas en el desarrollo de las competencias genéricas del pensamiento crítico. Se utilizó un método mixto con un diseño embebido y de tipo transeccional en un grupo de 27 personas de primer cuatrimestre de la materia de Introducción a la Nutrición y a la Dietética de la licenciatura en Nutrición, en una universidad privada de Iguala, Guerrero. Los instrumentos utilizados fueron el cuestionario de competencias genéricas individuales, sección de pensamiento crítico adaptado (Olivares et al., 2013: 9) y la rejilla de observación para las habilidades del pensamiento crítico (Facione, 1990: 15). Los resultados indicaron que la técnica mencionada presentó un efecto positivo en las habilidades relacionadas al juicio de una situación específica, con datos objetivos y subjetivos.
Responsabilidad social universitaria a través de los reportes de sostenibilidad del Global Reporting Initiative: experiencia de una universidad pública
Authors: Huerta-Riveros Patricia , Gaete-Feres Héctor 
Published: November 2017

Este artículo, lleva a cabo una aproximación al concepto de responsabilidad social universitaria y realiza una breve descripción de las metodologías para elaborar reportes de sostenibilidad, en particular del Global Reporting Initiative (GRI). Posteriormente, a través del análisis de contexto del GRI y la experiencia de una institución de educación superior, aporta evidencia empírica al respecto. Como resultados, se descubre que de 7 650 instituciones sólo 90 corresponden a universidades y, aplicando un estudio de caso a la Universidad del Bío-Bío, en Chile, se detecta que la metodología GRI permite dar cuenta de las actividades de responsabilidad social alcanzando el nivel A. Así se puede afirmar que los reportes de sostenibilidad muestran las actividades desarrolladas por las instituciones a través de un marco de certificación, al igual que sus compromisos de responsabilidad social.