bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the LIVESTRONG at the YMCA exercise program on physical activity, fitness, quality of life, and fatigue in cancer survivors
Authors: Irwin Melinda L. , Cartmel Brenda , Harrigan Maura , Li Fangyong , Sanft Tara , Shockro Laura , O'Connor Keelin , Campbell Nancy , Tolaney Sara M. , Mayer Erica L. , Yung Rachel , Freedman Rachel A. , Partridge Ann H. , Ligibel Jennifer A. 
Published: November 2016

BACKGROUNDPhysical activity (PA) has been linked to a lower risk of developing and dying of cancer, yet many cancer survivors do not exercise. In the current study, the authors evaluated the impact of the LIVESTRONG at the YMCA exercise program, available at Young Men's Christian Associations (YMCAs) across the United States, on PA, fitness, quality of life, fatigue, body composition, serum biomarkers, and program safety in cancer survivors.METHODSCancer survivors were recruited through the Yale Cancer Center and the Dana‐Farber Cancer Institute and randomized to a 12‐week, twice‐weekly LIVESTRONG at the YMCA exercise program at YMCAs in Connecticut or Massachusetts or to a control group. Questionnaires, dual‐energy x‐ray absorptiometry scans, 6‐minute walk tests (6MWTs), and a fasting blood draw were completed at baseline and at 12 weeks. Intervention effects were evaluated using mixed model repeated measures analysis, with changes at 12 weeks in PA and 6MWT as the primary endpoints.RESULTSA total of 186 participants were randomized (95 to the exercise group and 91 to the control group). The majority of patients were diagnosed with AJCC stage I to II cancer and 53% had breast cancer. Participants randomized to the LIVESTRONG at the YMCA program experienced increases in PA (71% exercising at ≥ 150 minutes/week vs 26% of controls; P<.05) and improvements in the 6MWT (group difference: 28.9 meters [95% confidence interval, 0.3‐49.0; P = .004]) and quality of life (group difference: 2.6 [95% confidence interval, 0.1‐5.0; P = .04]). No adverse events were reported.CONCLUSIONSThe LIVESTRONG at the YMCA exercise program has the potential to impact thousands of survivors across the YMCA network and could lead to improvements in disease and psychosocial outcomes in the growing population of cancer survivors. Cancer 2017;123:1249–1258. © 2016 American Cancer Society.
Light wavelengths of LEDs to improve the color discrimination in Ishihara test and Farnsworth Panel D‐15 test for deutans
Authors: Tamura Shigeharu , Okamoto Yosuke , Nakagawa Seiji , Sakamoto Takashi , Ando Masanori , Shigeri Yasushi 
Published: November 2016

AbstractThis study was performed to determine significant light wavelengths to improve color discrimination ability of subjects with deutan. We conducted both the Ishihara test and the Farnsworth Panel D‐15 test for subjects with deutan and normal color vision. Seven different LED lights from 450 to 660 nm and an additional D65 white lamp were utilized to change the lighting conditions, including the wavelength and intensity. The results of the Ishihara test and D‐15 test showed that color identification of deutans was markedly improved with the longer wavelength LEDs regardless of the intensity of the additional D65 lamp. Notably, the error rates of deutans in the Ishihara test were <25% for LED wavelengths of 630 and 660 nm. In the case of subjects with normal color vision, the D65 lamp abolished the errors in the Ishihara test, regardless of the LED wavelength. Addition of the D65 lamp also decreased the number of crossings in the D‐15 test. These results suggested that illumination by LED light with longer wavelengths, such as 630 and 660 nm, may provide deutans with greater red‐green discrimination ability in both the Ishihara test and the Farnsworth Panel D‐15 test. © 2016 Wiley Periodicals, Inc. Col Res Appl, 42, 424–430, 2017
Background luminance and subtense affects color appearance
Authors: Sun Pei‐Li , Li Hung‐Chung , Ronnier Luo M. 
Published: November 2016

AbstractTwo psychophysical experiments were conducted to investigate the color appearance under non‐uniform surround conditions with variation of stimulus luminance, surround luminance, background luminance, background orientation, and background size. The results show that the background size and surround luminance influence the appearance intensively, but that the orientation of background pattern has little effect. A method to determine optimal parameters for the CIECAM02 color appearance model in lighting applications is proposed. An UGR‐based model also is optimized for brightness estimation. The luminance of adapting field can be estimated by Gaussian‐like functions. © 2016 Wiley Periodicals, Inc. Col Res Appl, 42, 440–449, 2017
Breaking Sad: Unleashing the Breakthrough Potential of Ketamine's Rapid Antidepressant Effects
Authors: Feifel David 
Published: November 2016

ABSTRACT

Preclinical Research

The surprising results of a small clinical trial on the effects of low dose ketamine, a 65‐year old anesthetic drug that is also used off‐label for chronic pain and recreationally as a club drug, in eight depressed subjects unleashed the most significant advance in antidepressant drug development in decades. That study and subsequent ones have demonstrated that low dose, infused ketamine is able to induce a remission of depression in patients who have failed conventional medications, within 24 h. The apparent increased efficacy and rapid onset of effect of ketamine distinguish it from all other current antidepressant treatments. However, a single infusion of subanesthetic doses of ketamine produces benefits that typically last <3 weeks. The infusions are associated with a transient “psychedelic” experience and increased blood pressure that requires monitoring. There is also a theoretical potential to induce ketamine addiction. These features limit ketamine's ability to be a widely used treatment for depression and thus limit is ability to have a meaningful impact on the heavy morbidity and mortality associated with this disorder, despite its “breakthrough” rate of efficacy and speed of action. While growing numbers of clinicians are using ketamine to treat treatment resistant depression, many in the depression field believe that the aforementioned limiting aspects need to be separated from its remarkable therapeutic effects in order to unlock the breakthrough potential of this agent. To that end, drug development efforts have focused on various features of ketamine as targets for optimization including its modulation of the NMDA receptor, its pharmacokinetics, its chirality and its active metabolites including HNK (2R, 6R)‐hyroxynorketamine. Drug Dev Res 77 : 489–494, 2016. © 2016 Wiley Periodicals, Inc.
Association between body mass index and salivary uric acid among Mexican‐origin infants, youth and adults: Gender and developmental differences
Authors: Martínez Airín D. , Ruelas Lillian , Granger Douglas A. 
Published: November 2016

AbstractUric acid (UA) is the end product of the metabolic breakdown of purine nucleotides. Recent studies have measured UA in saliva in relation to obesity and chronic disease risk. Given the increasing prevalence of metabolic syndrome among Latino youth, we examined gender and age differences in salivary uric acid (sUA) and weight in a sample of Mexican‐origin children (n = 65, 2 months to 18 years, 49% female) and adults (n = 46, 19–58 years, 72% female). We measured weight, height, waist, and hip circumference and collected saliva samples (later assayed for sUA). Structural equation models estimated the relationship between age, developmental stage, and weight outcomes in relation to sUA levels between genders, while controlling for race. Results demonstrate that increased sUA levels were related to higher BMI percentiles in females of all ages (β = 0.43, p < .001). There were significant differences in sUA levels between developmental stages for girls, with female toddlers having the highest sUA levels (β = .28, p = .02). In an interaction between BMI z‐score and gender between youth and adults, BMI has a larger effect on increasing sUA levels among younger girls (β = 0.27, p < .03) and adult women (β = 0.33, p = .02). Levels of sUA may be gender‐specific in relation to BMI and developmental stage.
Stochastic model for simulation of near‐fault ground motions
Authors: Dabaghi Mayssa , Der Kiureghian Armen 
Published: November 2016

SummaryA parameterized stochastic model of near‐fault ground motion in two orthogonal horizontal directions is developed. The major characteristics of recorded near‐fault ground motions are represented. These include near‐fault effects of directivity and fling step; temporal and spectral non‐stationarity; intensity, duration, and frequency content characteristics; directionality of components; and the natural variability of ground motions. Not all near‐fault ground motions contain a forward directivity pulse, even when the conditions for such a pulse are favorable. The proposed model accounts for both pulse‐like and non‐pulse‐like cases. The model is fitted to recorded near‐fault ground motions by matching important characteristics, thus generating an ‘observed’ set of model parameters for different earthquake source and site characteristics. A method to generate and post‐process synthetic motions for specified model parameters is also presented. Synthetic ground motion time series are generated using fitted parameter values. They are compared with corresponding recorded motions to validate the proposed model and simulation procedure. The use of synthetic motions in addition to or in place of recorded motions is desirable in performance‐based earthquake engineering applications, particularly when recorded motions are scarce or when they are unavailable for a specified design scenario. Copyright © 2016 John Wiley & Sons, Ltd.
Wall building stiffness and strength effect on content sliding in Wellington seismic conditions
Authors: Yeow Trevor Z. , MacRae Gregory A. , Dhakal Rajesh P. 
Published: November 2016

SummaryA numerical study of unobstructed content sliding within several low‐to‐midrise reinforced concrete cantilever wall buildings designed to Wellington conditions in New Zealand is performed to validate the belief that increasing a building's strength and/or stiffness would result in more severe sliding response. It was shown that contents within stronger buildings experienced larger sliding response. If the building was designed to be strong, the sliding response of contents with a friction coefficient of 0.1 was smaller in stiffer buildings compared with those in flexible buildings. However, the trends start reversing with an increase in friction coefficient or a decrease in building strength. Overall, content sliding is not necessarily more severe in stiffer buildings, and in many cases, the opposite is true. This study's findings were compared against an existing parametric equation for estimating the maximum sliding displacement. This equation, which was originally derived for contents located within elastic frame buildings, was found to be more efficient than considering total floor accelerations alone but was underconservative by a mean of 17% for yielding multistorey buildings. A design procedure considering content sliding using the parametric equation and an example are provided. Copyright © 2016 John Wiley & Sons, Ltd.
Depressive symptoms, prediabetes, and incident diabetes in older English adults
Authors: Graham Eva , Au Bonnie , Schmitz Norbert 
Published: November 2016

ObjectiveThe objective of this study was to assess the risk of diabetes in older adults with elevated depressive symptoms, prediabetes, or both.MethodThis study included 4129 participants from the English Longitudinal Study of Ageing. Participants were followed from Wave 2 (2004–2005) to Wave 6 (2012–2013). The 8‐item Centre for Epidemiologic Studies Depression (CESD) scale was used to measure depressive symptoms in the past week, which were categorized as no/low, mild, or high. Normal glucose levels and prediabetes were defined using baseline haemoglobin A1c measurements. Incident diagnosed diabetes was reported by participants. Cox regression estimated hazard ratios of incident diabetes associated with depressive symptoms and prediabetes.ResultsA total of 157 participants were diagnosed with diabetes over a mean of 6.7 years. Relative to participants with normal glucose levels and no/low depressive symptoms at baseline, the adjusted hazard ratios were 0.85 (95% CI 0.40–1.82) and 1.62 (95% CI 0.84–3.15) for those with normal glucose levels and mild depressive symptoms and normal glucose levels and high depressive symptoms. The adjusted hazard ratios for participants with prediabetes and no/low depressive symptoms, mild depressive symptoms, and high depressive symptoms were 4.84 (95% CI 3.08–7.60), 7.17 (95% CI 4.00–12.88), and 7.77 (95% CI 4.33–13.93), respectively.ConclusionsOlder adults with elevated depressive symptoms and prediabetes have an increased risk of diabetes compared to those with only one of these risk factors. Copyright © 2016 John Wiley & Sons, Ltd.
A conceptual hydrogeological model of ophiolitic aquifers (serpentinised peridotite): The test example of Mt. Prinzera (Northern Italy)
Authors: Segadelli Stefano , Vescovi Paolo , Ogata Kei , Chelli Alessandro , Zanini Andrea , Boschetti Tiziano , Petrella Emma , Toscani Lorenzo , Gargini Alessandro , Celico Fulvio 
Published: November 2016

AbstractThe main aim of this study is the experimental analysis of the hydrogeological behaviour of the Mt. Prinzera ultramafic massif in the northern Apennines, Italy. The analysed multidisciplinary database has been acquired through (a) geologic and structural survey; (b) geomorphologic survey; (c) hydrogeological monitoring; (d) physico‐chemical analyses; and (e) isotopic analyses.The ultramafic medium is made of several lithological units, tectonically overlapped. Between them, a low‐permeability, discontinuous unit has been identified. This unit behaves as an aquitard and causes a perched groundwater to temporary flow within the upper medium, close to the surface. This perched groundwater flows out along several structurally controlled depressions, and then several high‐altitude temporary springs can be observed during recharge, together with several perennial basal (i.e., low altitude) springs, caused by the compartmentalisation of the system because of high‐angle tectonic discontinuities.
Plasmodium chabaudi infection induces AID expression in transitional and marginal zone B cells
Authors: Wilmore Joel R. , Maue Alexander C. , Rochford Rosemary 
Published: November 2016

AbstractIntroductionEndemic Burkitt's lymphoma (eBL) is associated with Epstein–Barr virus and repeated malaria infections. A defining feature of eBL is the translocation of the c‐myc oncogene to the control of the immunoglobulin promoter. Activation‐induced cytidine deaminase (AID) has been shown to be critical for this translocation. Malaria infection induces AID in germinal center B cells, but whether malaria infection more broadly affects AID activation in extrafollicular B cells is unknown.MethodsWe either stimulated purified B cells from AID‐green fluorescence protein (GFP) reporter mice or infected AID‐GFP mice with Plasmodium chabaudi, AID fluorescence was monitored in B cell subsets by flow cytometry.ResultsIn vitro analysis of B cells from these mice revealed that CpG (a Toll‐like receptor 9 ligand) was a potent inducer of AID in both mature and immature B cell subsets. Infection of AID‐GFP mice with Plasmodium chabaudi demonstrated that AID expression occurs in transitional and marginal zone B cells during acute malaria infection. Transitional B cells were also capable of differentiating into antibody secreting cells when stimulated in vitro with CpG when isolated from a P. chabaudi‐infected mouse.ConclusionsThese data suggest that P. chabaudi is capable of inducing AID expression in B cell subsets that do not participate in the germinal center reaction, suggesting an alternative role for malaria in the etiology of eBL.
Large Induced Forests in Graphs
Authors: Shi Lingsheng , Xu Hongyu 
Published: November 2016

AbstractIn this article, we prove three theorems. The first is that every connected graph of order n and size m has an induced forest of order at least with equality if and only if such a graph is obtained from a tree by expanding every vertex to a clique of order either 4 or 5. This improves the previous lower bound of Alon–Kahn–Seymour for , and implies that such a graph has an induced forest of order at least for . This latter result relates to the conjecture of Albertson and Berman that every planar graph of order n has an induced forest of order at least . The second is that every connected triangle‐free graph of order n and size m has an induced forest of order at least . This bound is sharp by the cube and the Wagner graph. It also improves the previous lower bound of Alon–Mubayi–Thomas for , and implies that such a graph has an induced forest of order at least for . This latter result relates to the conjecture of Akiyama and Watanabe that every bipartite planar graph of order n has an induced forest of order at least . The third is that every connected planar graph of order n and size m with girth at least 5 has an induced forest of order at least with equality if and only if such a graph is obtained from a tree by expanding every vertex to one of five specific graphs. This implies that such a graph has an induced forest of order at least , where was conjectured to be the best lower bound by Kowalik, Lužar, and Škrekovski.
Anti‐hypercholesterolemic influence of the spice cardamom (Elettaria cardamomum) in experimental rats
Authors: Nagashree Shamarao , Archana Kottangada K , Srinivas Pullabhatla , Srinivasan Krishnapura , Sowbhagya Halagur B 
Published: November 2016

AbstractBACKGROUNDCardamom (Elettaria cardamomum) is an aromatic seed spice grown extensively in India and used as a flavoring in sweets. In this study, the anti‐hypercholesterolemic effect of cardamom was evaluated in Wistar rats by inducing hypercholesterolemia with a high‐cholesterol diet for 8 weeks. Dietary interventions were made with (a) cardamom powder (50 g kg−1), (b) cardamom oil (3 g kg−1, equivalent to 50 g kg−1 cardamom) and (c) de‐oiled cardamom powder (50 g kg−1).RESULTSA significant reduction in blood total cholesterol (31%) and low‐density lipoprotein cholesterol (44%) was observed by oral administration of cardamom oil in hypercholesterolemic rats, accompanied by a marked decrease in serum triglycerides by 42%. The cholesterol content of cardiac muscle was beneficially lowered by 39% with administration of cardamom oil in hypercholesterolemic rats. Liver triglycerides were reduced by 33%. Incorporation of cardamom oil/powder in the diet did not alter feed consumption by rats. Compromised activities of hepatic antioxidant enzymes in the hypercholesterolemic situation were generally countered by dietary cardamom. Treatment with de‐oiled cardamom as well as cardamom oil countered the diminished activity of catalase in hypercholesterolemic animals. Cardamom also enhanced the activity of heart superoxide dismutase in the hypercholesterolemic situation. The concentration of ascorbic acid in serum was significantly increased by dietary cardamom or its fractions in the hypercholesterolemic situation.CONCLUSIONThis animal study has established the potential of cardamom oil in restoring the alteration in lipid homeostasis in conditions of hypercholesterolemia. The significant reduction in atherogenicity index by dietary intervention with cardamom powder and cardamom oil indicates the potential cardioprotective effect of cardamom. © 2016 Society of Chemical Industry
Chiral separation of benzothiazole derivatives of amino acids using capillary zone electrophoresis
Authors: Nováková Zuzana , Pejchal Vladimír , Fischer Jan , Česla Petr 
Published: November 2016

A method for the separation of enantiomers of leucine and phenylalanine benzothiazole derivatives as potential antimicrobial agents was developed using capillary zone electrophoresis with a dual cyclodextrin (CD) system. The best resolution of enantiomers was achieved in 100 mmol/L phosphate background electrolyte (pH 3.5) with the dual CD system consisting of 10 mmol/L of β‐CD with 10 mmol/L of 2‐hydroxypropyl‐β‐cyclodextrin for leucine derivative and 10 mmol/L of 2‐hydroxypropyl‐γ‐cyclodextrin for phenylalanine derivative, respectively. Under the optimal conditions, the highest enantioresolution of 1.25 was achieved in a noncoated‐fused silica capillary at 17°C and 24 kV applied voltage.
Simultaneous determination of pyrifluquinazon and its main metabolite in fruits and vegetables by using QuEChERS–HPLC–MS/MS
Authors: You Xiangwei , Sui Chengcheng , Li Yiqiang , Wang Xiuguo 
Published: November 2016

A rapid, reliable, and sensitive method is reported for the simultaneous analysis of pyrifluquinazon and its main metabolite NNI‐0101‐1H in fruits (strawberry and cherry) and vegetables (cucumber and tomato) using high‐performance liquid chromatography coupled with tandem mass spectrometry. A modified, quick, easy, cheap, effective, rugged, and safe procedure was used for the sample pre‐preparation. The target analytes were extracted with acetonitrile and then cleaned up using dispersive solid‐phase extraction procedure with primary secondary amine. Sample analysis was performed using electrospray ionization in positive mode. Good linearities with the correlation coefficients higher than 0.9991 were obtained in the range of 1–1000 μg/L under the optimized conditions. The average recoveries of the pyrifluquinazon and NNI‐0101‐1H were in the range of 71.4–106.0% with the relative standard deviations 1.8–11.8% in all matrices at three spiked levels (10, 100, and 1000 μg/kg). The limit of quantification 10 μg/kg was set as the lowest spiked level. The developed method is reliable and effective for the routine monitoring of pyrifluquinazon and its metabolite NNI‐0101‐1H in fruits and vegetables to ensure food safety.
Ferruginous hawk demography in areas differing in energy extraction activity
Authors: Wiggins David A. , Grzybowski Joseph A. , Schnell Gary D. 
Published: November 2016

ABSTRACTThe recent expansion of oil and gas extraction activity on the Great Plains, USA, has occurred with little understanding of potential effects of the activity on wildlife populations. We monitored the demography of breeding ferruginous hawks (Buteo regalis) in 2 areas of western North Dakota, USA, subject to different intensities of energy extraction. Northwestern North Dakota is the heart of the Bakken Shale, where oil and gas extraction activity has been intense (e.g., 1,273 new oil wells from 2011–2013 in our high‐intensity study area) in recent years. In contrast, such activity has occurred at a relatively low intensity (e.g., 18 new oil wells from 2011–2013 in our low‐intensity study area) in southwestern North Dakota. Ferruginous hawks in the 2 areas had similar densities of nesting pairs, with comparable fledging success. However, between‐year re‐use of nest sites was significantly lower in the area with high‐intensity energy extraction (1 of 8) than the area of low‐intensity (8 of 10); also, re‐use of nests in the high‐intensity area was considerably lower than reported from other parts of the range of the species. Thus, although high‐intensity energy extraction activity had no apparent impact on immediate reproductive success of ferruginous hawks, long‐term population declines could be expected in our northern study area given the unusually low rate of nest‐site re‐use. © 2016 The Wildlife Society.