bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-protein diet supplemented with ketoacids delays the progression of diabetic nephropathy by inhibiting oxidative stress in the KKAy mice model
Authors: Liu Dongmei , Wu Ming , Li Lin , Gao Xiang , Yang Bo , Mei Shuqin , Fu Lili , Mei Changlin 
Published: December 2017

AbstractDiabetic nephropathy (DN) is a major cause of chronic kidney disease. We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 weeks of age. A period of 12-week treatment with LPD significantly reduced albuminuria as compared with that observed after NPD treatment. Treatment with LPD+KA further reduced albuminuria as compared with that observed with LPD treatment alone. Moreover, LPD treatment reduced mesangial expansion, thickness of glomerular basement membrane and the severity of the podocyte foot process effacement in KKAy mice; these effects were more pronounced in KKAy mice treated with LPD+KA. Both LPD and LPD+KA treatments slightly reduced total body weight, but had no significant effect on kidney weight and blood glucose concentrations when compared with NPD-treated KKAy mice. LPD treatment slightly attenuated oxidative stress in kidneys as compared with that observed in NPD-treated KKAy mice; however, LPD+KA treatment remarkably ameliorated oxidative stress in diabetic kidneys as shown by decreased malondialdehyde concentrations, protein carbonylation, nitrotyrosine expression and increased superoxide dismutase expression. Nutritional therapy using LPD+KA confers additional renal benefits as compared with those of LPD treatment alone in early type 2 DN through inhibition of oxidative stress.
Antichagasic effect of crotalicidin, a cathelicidin-like vipericidin, found in Crotalus durissus terrificus rattlesnake's venom gland
Authors: Bandeira Izabel Cristina Justino , Bandeira-Lima Danya , Mello Clarissa Perdigão , Pereira Ticiana Praciano , De Menezes Ramon Róseo Paula Pessoa Bezerra , Sampaio Tiago Lima , Falcão Cláudio Borges , Rádis-Baptista Gandhi , Martins Alice Maria Costa 
Published: December 2017

AbstractCathelicidins are antimicrobial peptides produced by humans and animals in response to various pathogenic microbes. Crotalicidin (Ctn), a cathelicidin-related vipericidin from the South American Crotalus durissus terrificus rattlesnake's venom gland, and its fragments have demonstrated antimicrobial and antifungal activity, similarly to human cathelicidin LL-37. In order to provide templates for the development of modern trypanocidal agents, the present study evaluated the antichagasic effect of these four peptides (Ctn, Ctn[1-14], Ctn[15-34] and LL-37). Herein, Ctn and short derived peptides were tested against the epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi Y strain (benznidazole-resistant strain) and cytotoxicity in mammalian cells was evaluated against LLC-MK2 lineage cells. Ctn inhibited all T. cruzi developmental forms, including amastigotes, which is implicated in the burden of infection in the chronic phase of Chagas disease. Moreover, Ctn showed a high selective index against trypomastigote forms (>200). Ctn induced cell death in T. cruzi through necrosis, as determined by flow cytometry analyses with specific molecular probes and morphological alterations, such as loss of membrane integrity and cell shrinkage, as observed through scanning electron microscopy. Overall, Ctn seems to be a promising template for the development of antichagasic agents.
A survey of author name disambiguation techniques: 2010–2016
Authors: Hussain Ijaz , Asghar Sohail 
Published: December 2017

AbstractDigital libraries content and quality of services are badly affected by the author name ambiguity problem in the citations and it is considered as one of the hardest problems faced by the digital library researchers. Several techniques have been proposed in the literature for the author name ambiguity problem. In this paper, we reviewed some recently presented author name disambiguation techniques and give some challenges and future research directions. We analyze the recent advancements in this field and classify these techniques into supervised, unsupervised, semi-supervised, graph-based and heuristic-based techniques according to their problem formulation that is mainly used for the author name disambiguation. A few surveys have been conducted to review different techniques for the author name disambiguation. These surveys highlighted only the methodology adopted for author name disambiguation but did not critically review their shortcomings. This survey provides a detailed review of author name disambiguation techniques available in the literature, makes a comparison of these techniques at an abstract level and discusses their limitations.
THE EFFECTS OF PROCESSING INSTRUCTION AND TRADITIONAL INSTRUCTION ON L2 ONLINE PROCESSING OF THE CAUSATIVE CONSTRUCTION IN FRENCH
Authors: Wong Wynne , Ito Kiwako 
Published: December 2017

AbstractWhile previous research has shown that processing instruction (PI) can more effectively facilitate the acquisition of target structures than traditional drill practice, the processing mechanism of PI has not been adequately examined because most assessment tasks have been offline. Using eye-tracking, this two-experiment study compared changes in processing patterns between two types of training: PI and traditional instruction (TI) on intermediate-level L2 learners’ acquisition of the French causative. Both experiments used a pretraining/posttraining design involving a dichotomous scene selection eye-tracking task to measure eye-movement patterns and accuracy in picture selection while participants processed auditory sentences. Neither group received explicit information (EI) in Experiment 1 while both experimental groups in Experiment 2 received EI before processing sentences. Results of Experiment 1 revealed the PI group had significantly higher accuracy scores than the TI group. A change in eye-movement pattern was also observed after training for the PI group but not for the TI group. In Experiment 2, when both groups received EI, PI subjects were again significantly more accurate than TI subjects, but both groups’ accuracy scores were not reliably higher than subjects in the PI and TI groups in Experiment 1 who did not receive EI. Eye-movement patterns in Experiment 2 showed that both TI and PI started to shift their gaze to the correct picture at the same point as PI subjects did in Experiment 1. This suggests that EI helped the TI group start entertaining the correct picture as a possible response sooner but the EI did not help the PI group process the target structure sooner than the TI group.
Das durch den Knecht gespendete Almosen
Authors: Landgraf Artur Michael 
Published: December 2017

S. Kuttner hat in seinem grundlegenden Werk über die Kanonistische Schuldlehre von Gratian bis auf die Dekretalen Gregors IX. bereits das vermerkt, was die kanonistische Literatur der Frühzeit über die möglichen äusseren Formen des Anteiles mehrerer an der Deliktsverwirklichung bringt, und festgestellt, dass alle solche Erörterungen auf der Grundauffassung der Teilnahme als einer geistigen Schuldart und nicht — denn der consensus kann der Tat des andern auch nachfolgen — auf der Prüfung der kausalen Bedeutung des Teilnehmens ruhten. Er verweist dabei auch darauf, dass sich mannigfache Einteilungen über consensus negligentiae, cooperationis, defensionis, auxilio, licentia, approbando, auctoritate, praecepto, mandando, consilio, patrocinio finden.In der Frühscholastik fand sich nun das Problem der fremden Sünde nicht eben häufig berührt. Was sich aber darüber findet, gewährt immerhin einen interessanten Einblick in die Behandlung des Problems ausserhalb der Kanonistik.
Canon Law in Manuscripts from Medieval Sweden
Authors: Schmid Toni 
Published: December 2017

This is not an inventory of medieval books shelved and catalogued in modern Swedish libraries. It is something more special, in fact the material dealt with in this note seems to be a phenomenon of Sweden, not found in other countries, at least not to the same extent.When Protestantism (of the Lutheran variety) became the creed of the king and the people, books of a different kind were needed in churches and schools. Church services were gradually altered and instead of Latin, the Swedish language was used. The number of monks dwindled, the convents became poor and finally ceased to exist. No longer were the Latin service books used, nor Latin Bibles read. The printers could soon put any amount of new books at the scholar's disposal.
A Rhenish 'Sammelband’ of the Fifteenth Century Libri impressi cum notis manuscriptis—IV
Authors: Bühler Curt F. 
Published: December 2017

Libri impressi cum notis manuscriptis—IVUnder the title ‘A South German “Sammelband” of the Fifteenth Century’ the present writer recently published an analysis of a composite volume of early printed books and manuscript texts in the Pierpont Morgan Library. Another volume of the same sort also found in the Morgan Library (PML 22222) presents a similar problem for investigation; the results of such study seem sufficiently important to justify the publication of the pertinent details. Only one other manuscript of but one of the eleven manuscript texts found in the volume is listed as being in America, thus indicating that these works are not of common occurrence. Neither the incipits nor the titles are noted in the standard works of reference, though the literary contents of the volume are varied in scope and interest.
Performances of statistical methods for the detection of seasonal influenza epidemics using a consensus-based gold standard
Authors: SOUTY C. , JREICH R. , LE STRAT Y. , PELAT C. , BOËLLE P. Y. , GUERRISI C. , MASSE S. , BLANCHON T. , HANSLIK T. , TURBELIN C. 
Published: December 2017

SUMMARYInfluenza epidemics are monitored using influenza-like illness (ILI) data reported by health-care professionals. Timely detection of the onset of epidemics is often performed by applying a statistical method on weekly ILI incidence estimates with a large range of methods used worldwide. However, performance evaluation and comparison of these algorithms is hindered by: (1) the absence of a gold standard regarding influenza epidemic periods and (2) the absence of consensual evaluation criteria. As of now, performance evaluations metrics are based only on sensitivity, specificity and timeliness of detection, since definitions are not clear for time-repeated measurements such as weekly epidemic detection. We aimed to evaluate several epidemic detection methods by comparing their alerts to a gold standard determined by international expert consensus. We introduced new performance metrics that meet important objective of influenza surveillance in temperate countries: to detect accurately the start of the single epidemic period each year. Evaluations are presented using ILI incidence in France between 1995 and 2011. We found that the two performance metrics defined allowed discrimination between epidemic detection methods. In the context of performance detection evaluation, other metrics used commonly than the standard could better achieve the needs of real-time influenza surveillance.
The Meat City: urban space and provision in industrial Copenhagen, 1880–1914
Authors: THELLE MIKKEL 
Published: December 2017

ABSTRACT:This article investigates the emergence of the Copenhagen slaughterhouse, called the Meat City, during the late nineteenth century. This slaughterhouse was a product of a number of heterogeneous components: industrialization and new infrastructures were important, but hygiene and the significance of Danish bacon exports also played a key role. In the Meat City, this created a distinction between rising production and consumption on the one hand, and the isolation and closure of the slaughtering facility on the other. This friction mirrored an ambivalent attitude towards meat in the urban space: one where consumers demanded more meat than ever before, while animals were being removed from the public eye. These contradictions, it is argued, illustrate and underline the change of the city towards a ‘post-domestic’ culture. The article employs a variety of sources, but primarily the Copenhagen Municipal Archives for regulation of meat provision.
Neuropsychological outcomes in CHD beyond childhood: a meta-analysis
Authors: Mills Rónán , McCusker Christopher G. , Tennyson Chris , Hanna Donncha 
Published: December 2017

AbstractBackgroundRisk for neurodevelopmental delay in infants and children with CHD is well established, but longer-term outcomes are equivocal. A meta-analysis was conducted to establish whether cognitive deficits remain beyond childhood – into teenage and young adult years.Methods and resultsA total of 18 unique samples, involving adolescents, teenagers, and adults with CHD significant enough to require invasive intervention, and sourced through searches of Web of Science, MEDLINE, CINAHL Plus, and PsychInfo, met the inclusion criteria. These included the use of standardised neuropsychology tests across 10 domains of cognitive functioning and the reporting of effect size differences with controls. Reports of patients with chromosomal or genetic abnormalities were excluded. Pooled effect sizes suggested no significant differences between CHD samples and controls in terms of general intellectual ability and verbal reasoning. However, small–medium effects sizes were noted (0.33–0.44) and were statistically significant within the domains of non-verbal reasoning, processing speed, attention, auditory–verbal memory, psychomotor abilities, numeracy, and literacy with executive functioning also emerging as significant when one study outlier was excluded. We also included quality assurance statistics including Cochran’s Q, T, and I2 statistics, leave-one-out analyses, and assessment of publication bias. These often suggested study variability, possibly related to the heterogeneity of diagnostic groups included, and different tests used to measure the same construct.ConclusionsHeterogeneity indicated that moderators affect cognitive outcomes in CHD. Nevertheless, deficits across cognitive domains were discerned, which are likely to have functional impact and which should inform practice with this clinical population.
Use of Confocal Microscopy to Evaluate Equine Zygote Development After Sperm Injection of Oocytes MaturedIn VivoorIn Vitro
Authors: Ruggeri Elena , DeLuca Keith F. , Galli Cesare , Lazzari Giovanna , DeLuca Jennifer G. , Stokes Joanne E. , Carnevale Elaine M. 
Published: December 2017

AbstractConfocal microscopy was used to image stages of equine zygote development, at timed intervals, after intracytoplasmic sperm injection (ICSI) of oocytes that were maturedin vivoorin vitro. After fixation for 4, 6, 8, 12, or 16 h after ICSI, zygotes were incubated withα/βtubulin antibodies and human anticentromere antibody (CREST/ACA), washed, incubated in secondary antibodies, conjugated to either Alexa 488 or Alexa 647, and incubated with 561-Phalloidin and Hoechst 33258. An Olympus IX81 spinning disk confocal microscope was used for imaging. Data were analyzed usingχ2and Fisher’s exact tests. Minor differences in developmental phases were observed for oocytes maturedin vivoorin vitro. Oocytes formed pronuclei earlier when maturedin vivo(67% at 6 h and 80% at 8 h) thanin vitro(13% at 6 and 8 h); 80% of oocytes maturedin vitroformed pronuclei by 12 h. More (p=0.04) zygotes had atypical phenotypes, indicative of a failure of normal zygote development, when oocyte maturation occurredin vitroversusin vivo(30 and 11%, respectively). Some potential zygotes from oocytes maturedin vivohad normal phenotypes, although development appeared to be delayed or arrested. Confocal microscopy provided a feasible method to assess equine zygote development using limited samples.
The role of anxious distress in immune dysregulation in patients with major depressive disorder
Authors: Gaspersz Roxanne , Lamers Femke , Wittenberg Gayle , Beekman Aartjan T. F. , van Hemert Albert M. , Schoevers Robert A. , Penninx Brenda W. J. H. 
Published: December 2017

AbstractAlthough depression with anxious distress appears to be a clinically relevant subtype of major depressive disorder (MDD), whether it involves specific pathophysiology remains unclear. Inflammation has been implicated, but not comprehensively studied. We examined within a large MDD sample whether anxious distress and related anxiety features are associated with differential basal inflammation and innate cytokine production capacity. Data are from 1078 MDD patients from the Netherlands Study of Depression and Anxiety. In addition to the DSM-5 anxious distress specifier, we studied various dimensional anxiety scales (e.g. Inventory of Depressive Symptomatology anxiety arousal subscale [IDS-AA], Beck Anxiety Inventory [BAI], Mood and Anxiety Symptoms Questionnaire Anxious Arousal scale [MASQ-AA]). The specifier was constructed using five self-report items from the IDS and BAI. Basal inflammatory markers included C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Innate production capacity was assessed by 13 lipopolysaccharide (LPS)-stimulated inflammatory markers. Basal and LPS-stimulated inflammation index scores were created. Basal inflammation was not associated with anxious distress (prevalence = 54.3%) in MDD patients, except for a modest positive association for BAI score. However, anxious distress was associated with higher LPS-stimulated levels (interferon-γ, IL-6, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1α, matrix metalloproteinase (MMP)-2, TNF-α, LPS-stimulated index). Other anxiety indicators (anxious distress specifier score, BAI, MASQ-AA) were also associated with increased innate production capacity. Within a large MDD sample, the anxious distress specifier was associated with increased innate cytokine production capacity but not with basal inflammation. Results from dimensional anxiety indicators largely confirm these results. These findings provide new insight into the pathophysiology of anxious depression.
Ringing phenomenon based measurement of weak mode-coupling strength in an optical microresonator
Authors: Ye Ming-Yong , Shen Mei-Xia , Lin Xiu-Min 
Published: December 2017

AbstractThere is always a coupling between the degenerate clockwise (CW) and counter-clockwise (CCW) modes in a whisperinggallery- mode (WGM) optical microresonator, since the surface of the microresonator can not be perfectly smooth. It is important to measure this coupling strength in many applications. When the coupling strength is strong, the conventional method by observing mode splitting in the stationary spectrum can be used to measure its value. However, when the coupling strength is weak, the conventional method will not work. We experimentally demonstrate that the ringing phenomenon can be used to measure weak coupling strength between the CW and CCW modes in a WGM optical microresonator.
Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction
Authors: Naik Mandar T. , Kang Mooseok , Ho Chun-Chen , Liao Pei-Hsin , Hsieh Yung-Lin , Naik Nandita M. , Wang Szu-Huan , Chang Iksoo , Shih Hsiu-Ming , Huang Tai-Huang 
Published: December 2017

AbstractThe negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the consensus Ψ-K-x-E/D sumoylation motif. We have previously shown that acetylation of the SUMO E2 conjugase enzyme, Ubc9, at K65 downregulates its binding to the NDSM and renders a selective decrease in sumoylation of substrates with the NDSM motif. Here, we provide detailed structural, thermodynamic, and kinetics results of the interactions between Ubc9 and its K65 acetylated variant (Ac-Ubc9K65) with three NDSMs derived from Elk1, CBP, and Calpain2 to rationalize the mechanism beneath this reduced binding. Our nuclear magnetic resonance (NMR) data rule out a direct interaction between the NDSM and the K65 residue of Ubc9. Similarly, we found that NDSM binding was entropy-driven and unlikely to be affected by the negative charge by K65 acetylation. Moreover our NMR, mutagenesis and molecular dynamics simulation studies defined the sequence of the NDSM as Ψ-K-x-E/D-x1-x2-(x3/E/D)-(x4/E/D)-xn and determined that K74 and K76 were critical Ubc9 residues interacting with the negatively charged residues of the NDSM.
Heart Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy
Authors: Nagata Yoji , Yamagishi Masakazu , Konno Tetsuo , Nakanishi Chiaki , Asano Yoshihiro , Ito Shin , Nakajima Yuri , Seguchi Osamu , Fujino Noboru , Kawashiri Masa-aki , Takashima Seiji , Kitakaze Masafumi , Hayashi Kenshi 
Published: December 2017

AbstractThe pathogenesis of heart failure associated with dilated cardiomyopathy (DCM) may result in part from adenosine triphosphate (ATP) dysregulation in the myocardium. Under these conditions, diabetes-associated protein in insulin-sensitive tissue (DAPIT), which is encoded by the upregulated during skeletal muscle growth 5 (USMG5) gene, plays a crucial role in energy production by mitochondrial ATP synthase. To determine whether USMG5 is related to the development of heart failure, we performed clinical and experimental studies. Microarray analysis showed that the expression levels of USMG5 were positively correlated with those of natriuretic peptide precursor A in the human failed myocardium. When endogenous z-usmg5 in zebrafish was disrupted using morpholino (MO) oligonucleotides, the pericardial sac and atrial areas were larger and ventricular fractional shortening was reduced compared to in the control MO group. The expression levels of natriuretic peptides were upregulated in the z-usmg5 MO group compared to in controls. Further, microarray analysis revealed that genes in the calcium signalling pathway were downregulated in the z-usmg5 MO group. These results demonstrate that DAPIT plays a crucial role in the development of heart failure associated with DCM and thus may be a therapeutic target for heart failure.
A reduced cell-based phase model for tissue polarity alignment through global anisotropic cues
Authors: Sugimura Kaori , Kori Hiroshi 
Published: December 2017

AbstractOrdered polarity alignment of cell populations plays vital roles in biology, such as in hair follicle alignment and asymmetric cell division. Although cell polarity is uniformly oriented along a tissue axis in many tissues, its mechanism is not well understood. In this paper, we propose a theoretical framework to understand the generic dynamical properties of polarity alignment in interacting cellular units, where each cell is described by a reaction–diffusion system, and the cells further interact with one another through the contacting surfaces between them. Using a perturbation method under the assumption of weak coupling between cells, we derive a reduced model in which polarity of each cell is described by only one variable. Essential dynamical properties including the effects of cell shape, coupling heterogeneity, external signal and noise can be clarified analytically. In particular, we show that the anisotropicity of the system, such as oriented cell elongation and axial asymmetry in the coupling strength, can serve as a global cue that drives the uniform orientation of cell polarity along a certain axis. Our study bridges the gap between detailed and phenomenological models, and it is expected to facilitate the study of polarity dynamics in various nonequilibrium systems.