bluuebunny/crossref_metadata_2025_split huggingface dataset:
The sucrose challenge symptoms test optimized for diagnosis of congenital sucrase isomaltase deficiency
Authors: Street Kasidy , Tao Weng , Cash Brooks , Leung John , Hayes Christopher , Cooper Derick , Peterson Ward 
Published: September 2024

Background
Congenital sucrase isomaltase deficiency (CSID), an inherited carbohydrate malabsorption disorder, is difficult to diagnose because of overlapping symptoms with other gastrointestinal (GI) diseases. An at-home study was conducted in CSID and healthy adults to evaluate the diagnostic utility of self-reported GI symptoms following administration of a sucrose challenge.

Methods
This study investigated the optimum symptom scoring with a sucrose challenge symptoms test (SCST) for diagnosing CSID in 45 confirmed patients and 118 healthy controls. Subjects self-reported the severity of GI symptoms using a 10-point Likert scale after ingesting 50 grams of sucrose on an empty stomach. The receiver operator characteristics curve (ROC) was used to identify the diagnostic variable with the highest Youden Index, a measure of diagnostic performance.

Results
All six symptoms were significantly worse in the CSID group within 2 hours after the sucrose challenge. The diagnostic variable with the highest Youden Index was worsening in global symptoms scores at 1- and 2-hours (11.7 [CSID] vs 3.2 [Controls]; P<0.001.) Optimized by gender, the sensitivity and specificity for this diagnostic variable were 87% and 81%, respectively.

Conclusions
The SCST is a simple, non-invasive at-home test that can aid in a CSID diagnosis.
The Expediency Principle of Inanimate Land: a Study of Ihya' al-Mawat in Classical Fiqh and Land Reform in Indonesian Agrarian Law
Authors: Wahyuni Sri 
Published: September 2024

This article examines the comparison between the fiqh concept of iḥyā' al-mawāt and Indonesian national agrarian law on land reform, especially the right to open land. The author uses a comparative approach in this discussion, which compares the existing concepts in fiqh (as Islamic law) and national agrarian law (as Indonesian positive law). This article contributes to the discourse on Islamic land law, also known as agrarian fiqh, which has not been widely studied. This article shows that in the classical Islamic literature, there has been a study of land and how the Prophet Muhammad PBUH regulated land management. One of the concepts in fiqh is iḥyā' al-mawāt, which is to revive dead land. This is a starting point to introduce the tradition of agrarian fiqh in the classical literature. This article concludes that in both fiqh and Indonesian agrarian law, there is a concept of land clearing based on the principle of expediency. However, iḥyā' al-mawāt and the Indonesian national agrarian law on land reform still have differences, both in terms of concept, regulation, and implementation. This article is limited to a literature review that must be further studied from the context of the application of these two laws. This article contributes to the understanding of the two laws that are applied in Indonesia, namely positive law and Islamic law.

Artikel ini mengkaji tentang perbandingan antara konsep fiqh tentang iḥyā’ al-mawāt dan hukum agraria nasional Indonesia tentang land reform, terutama hak membuka lahan. Penulis menggunakan pendekatan perbandingan dalam pembahasan ini, yaitu membandingkan konsep yang ada dalam fiqh (sebagai hukum Islam) dan hukum agraria nasional (sebagai hukum positif Indonesia). Artikel ini memberikan kontribusi tentang wacana hukum pertanahan Islam atau dapat juga disebut sebagai fiqh agraria yang belum banyak dikaji. Artikel ini menunjukkan bahwa dalam khazanah Islam klasik telah dikenal kajian tentang tanah dan bagaimana Nabi Muhammad saw. mengatur tentang pengelolaan tanah. Salah satu konsep dalam fiqh adalah iḥyā’ al-mawāt, yaitu menghidupkan tanah mati. Hal ini menjadi satu titik awal untuk memperkenalkan tradisi fiqh agraria dalam khazanah klasik. Dari artikel ini dapat diambil kesimpulan bahwa baik dalam fiqh maupun dalam hukum agraria Indonesia terdapat konsep tentang membuka lahan yang berdasarkan asas kemanfaatan. Dalam fiqh dikenal dengan istilah iḥyā’ al-mawāt dan dalam hukum agraria dikenal adanya hak membuka lahan. Namun demikian, iḥyā’ al-mawāt dan hukum agraria nasional Indonesia tentang land reform tetap memiliki perbedaan, baik dari segi konsepnya, pengaturannya, maupun dari segi pelaksanaannya. Artikel ini sebatas kajian Pustaka yang harus dilanjutkan kajiannya dari aspek implementasi dua hukum tersebut. Artikel ini berkontribusi pada pemahaman dua hukum yang berlaku di Indonesia, yaitu hukum positif dan hukum Islam.
Comparative transcriptomics of broad‐spectrum and synthetic cannabidiol treated C2C12 skeletal myotubes
Authors: Gillham Scott H. , Cole Paige L. , Viggars Mark R. , Nolan Andy H. , Close Graeme L. , Owens Daniel J. 
Published: September 2024

AbstractCannabidiol (CBD) is widely used in sports for recovery, pain management, and sleep improvement, yet its effects on muscle are not well understood. This study aimed to determine the transcriptional response of murine skeletal muscle myotubes to broad‐spectrum CBD and synthetic CBD (sCBD). Differentiated C2C12 myotubes were treated with 10 μM CBD, sCBD, or vehicle control (DMSO) for 24 h before RNA extraction. Poly‐A tail‐enriched mRNA libraries were constructed and sequenced using 2 × 50 bp paired‐end sequencing. CBD and sCBD treatment induced 4489 and 1979 differentially expressed genes (DEGs; p < 0.001, FDR step‐up <0.05), respectively, with common upregulation of 857 genes and common downregulation of 648 genes. Common upregulated DEGs were associated with “response to unfolded protein,” “cell redox homeostasis,” “endoplasmic reticulum stress,” “oxidative stress,” and “cellular response to hypoxia.” Common downregulated DEGs were linked to “sarcomere organization,” “skeletal muscle tissue development,” “regulation of muscle contraction,” and “muscle contraction.” CBD treatment induced unique DEGs compared to sCBD. The data indicate CBD may induce mild cellular stress, activating pathways associated with altered redox balance, unfolded protein response, and endoplasmic reticulum stress. We hypothesize that CBD interacts with muscle and may elicit a “mitohormetic” effect that warrants further investigation.
From London to the Continent: Rethinking Corporate Governance Codes in Europe
Authors: Marchetti Piergaetano , Passador Maria Lucia 
Published: September 2024

Abstract
This paper critically evaluates the arguments proposed by Cheffins and Reddy in their recent article, advocating for the abolition of the UK Corporate Governance Code with the promise of substantial benefits to the market. The exploration primarily delves into the potential ramifications of such a proposal on other European jurisdictions, where Codes of corporate governance hold significant sway in the corporate domain, reflecting a spectrum of legal and cultural traditions. While the article under scrutiny is geographically confined to the United Kingdom, the ramifications of such a proposal extend far beyond, resonating deeply with the pervasive influence of the UK Code of Corporate Governance even within continental Europe, urging a comprehensive examination.The analysis begins by revisiting the arguments advanced by the authors and scrutinizing them in light of the Continental European context. This examination reveals several concerns that necessitate attention. We contend that despite geographic limitations, the Code serves as a valuable and adaptable instrument for fostering accountability, transparency, and innovation in markets transcending borders and jurisdictions. Its continued relevance is underscored by its utility in addressing emergent issues and governance challenges, particularly in the realm of ESG and auditing. Consequently, the proposition of its abolition carries significant drawbacks for both companies and investors alike. In conclusion, we assert that European jurisdictions should not dismiss Codes of corporate governance outright, but rather advocate for their refinement and adaptation to the evolving imperatives of the globalized 130economy. Such an approach is deemed imperative to maintain and enhance corporate governance standards, thereby ensuring the continued integrity and efficiency of European markets.
Tax Reforms and the Decline of the London Stock Market: The Untold Story
Authors: Gomtsian Suren , Schuster Edmund 
Published: September 2024

Abstract

234
Various reasons have been put forward for the declining global relevance of the London equity market. Reform proposals and changes already implemented target some of the major problems identified as reasons for the stock market’s decline. Surprisingly, tax related explanations for the current state of the UK stock market are largely absent from the discourse. This paper argues that the preferential tax treatment of the dividend income of UK pension funds and insurance companies introduced in the early 1970s and repealed in the mid 1990s first contributed to the UK stock market’s growth by implicitly subsidising financing via equity and encouraging the flow of the funds of these investors into the market, and subsequently led to the market’s decline as a result of the outflow of the funds of the two major classes of institutional investors: UK pension funds and insurance companies. The key implication of this argument is that omitting tax as a major factor in the decline of the UK stock market risks ending up with reforms that can, at best, do little to change the current situation.
Design, synthesis, and characterization of novel copolymer gel particles for water-plugging applications
Authors: Zhang Ding-Jun , Zhang Mei-Ju , Luo Zhan-Dong , Zhang Sheng-Xiang 
Published: September 2024

Abstract
Multi-stage plugging represents a promising strategy for enhancing production and injection rates in medium-and low-permeability oilfields. Despite its potential, the efficacy of current plugging agents, particularly hydrophobically bonded water-soluble polyacrylamide-based gel microspheres, is hindered by notable drawbacks such as low stability and inadequate compressive strength. Therefore, a comprehensive understanding of water plugging mechanisms coupled with the optimization of gel microsphere properties is essential for advancing the development of gel-based plugging agents with superior characteristics or intelligent regulatory capabilities. The P(AA-AM-[PrSO3]Vim) ionic liquid copolymerized gel particles were designed and synthesized by using microfluidic technique and titration gel method with AM, acrylic acid (AA), 1-vinylimidazole (Vim) and 1,3-propylsulfonyl lactone (PrSO3) as the raw materials. The morphology and structure of the copolymer gel particles were characterized, and the effects of [PrSO3]Vim and cross-linker content on the water-absorbing properties and strength of the gel particles were investigated. When the amount of [PrSO3]Vim was 12%, the concentration of crosslinker was 1.5%, and the temperature was 40°C, the water absorption capacity reached the maximum value of 163 g·g−1. The strength of the P(AA–AM–[PrSO3]Vim) spherical gel particles was maximized at a [PrSO3]Vim content of 4%. Furthermore, the chemical and physical roles of the P(AA–AM–[PrSO3]Vim) spherical gel particles were studied in a typical water-plugging environment. This study provides experimental data and a theoretical basis for the application of functional spherical gel-plugging particles in current oilfield environments.
Histone methylation and acetylation in cancer: mechanism, progression, and targets
Authors: Bu Su , Ye Ting , Gao Hang , Song Hang , Zhu Yongfu 
Published: September 2024

Abstract
Along with the continuous development of chromatin immunoprecipitation sequencing and its derivative technologies, as well as an increased understanding of epigenetic modification, the post-translational modification of histones has gradually been revealed, including their acetylation, methylation, phosphorylation, and ubiquitination, and their roles in diseases, especially cancer, have also been gradually explored. The role and regulation of histone methylation and acetylation in cancer and the mechanism of action of drugs have been thoroughly discussed. In particular, the review highlights recent advances in the development of epigenetic-targeted therapies and the challenges that remain in translating these findings into clinical applications. Research on epigenetic-targeted drugs is in its infancy, and more research in the fields of dominant biology, structural biology, and pharmacodynamics is needed. Through this review, the authors aim to provide theoretical guidance for the construction and clinical transformation of histone methylation and acetylation.
Use of different vegetation indices for the evaluation of the kinetics of the cherry tomato (Solanum lycopersicum var. cerasiforme) growth based on multispectral images by UAV
Authors: Chávez-Martínez Osiris , Monjardin-Armenta Sergio Alberto , Rangel-Peraza Jesús Gabriel , Sanhouse-García Antonio Jesus , Mora-Felix Zuriel Dathan , Plata-Rocha Wenseslao 
Published: September 2024

Abstract
This study evaluated seven vegetation indices for the monitoring of a cherry tomato crop using an unmanned aerial vehicle with a multispectral camera that measures in the green, red, and near-infrared spectral bands. A photogrammetric flight plan was designed to capture the spectral images every 2 weeks in two agricultural parcels identified as Treatment 1 (

T

1

{T}_{1}

) and Treatment 2 (

T

2

{T}_{2}

). The corresponding orthophotographs were obtained using digital photogrammetry techniques. Subsequently, vegetation indices were calculated for these orthophotographs. The mean and standard deviation of these indices were extracted, and a statistical analysis was performed to compare the vegetation indices and to analyze their behavior over time. Analysis of variance showed that the ratio vegetation index (RVI), green vegetation index (GVI), normalized difference vegetation index (NDVI), infrared percentage vegetation index (IPVI), green normalized difference vegetation index (GNDVI), and optimized soil-adjusted vegetation index (OSAVI) indices showed significant variation (P-value <0.05) over time. No statistically significant differences between the two treatments were found. IPVI, NDVI, and OSAVI showed less variation in pixel values. RVI, GVI, NDVI, IPVI, GNDVI, and OSAVI proved to be valuable tools for monitoring field crops since these indices responded to the crop growth kinetics.
Bedingungsloses vs. haushaltstyp- und wohnortabhängiges Grundeinkommen: Simulation verschiedener Reformszenarien für Deutschland
Authors: Bätz Benjamin , Becker Susanne , Calisse Frank , Englmann Frank , Isaak Niklas , Jessen Robin , Thiele Jonathan 
Published: September 2024

Zusammenfassung
Das Bedingungslose Grundeinkommen (BGE) zählt zu den bekanntesten Vorschlägen für eine Reform der Grundsicherung. Befürworter*innen erhoffen sich eine Vereinfachung des Sozialstaats. Frank Englmann, Robin Jessen, Benjamin Bätz, Susanne Becker, Frank Calisse, Niklas Isaak und Jonathan Thiele zeigen in diesem Beitrag, dass bei Einführung eines Grundeinkommens indes nur eine Auswahl an bestehenden Sozialleistungen wegfallen könnte. Die Autor*innen untersuchen via Mikrosimulation die Verteilungswirkung dreier Reformszenarien bei Einführung eines Grundeinkommens und gleichzeitiger Streichung ausgewählter Sozialleistungen. Die Gegenfinanzierung erfolgt jeweils durch Varianten einer Einkommensteuererhöhung. Wenn man zu erwartende Arbeitsangebotsreaktionen ins Kalkül einbezieht, sind die untersuchten BGE-Reformen nicht finanzierbar – zielgenauere Alternativszenarien, die den jeweiligen Haushaltskontext und die Mietkosten berücksichtigen, hingegen schon. Im Vergleich zum Status quo erfolgt in allen Szenarien eine starke Umverteilung nach unten.
Complex Palais matrix and a new unitary transform with bounded component norms
Authors: Kudo Shuhei 
Published: September 2024

Abstract
The Palais matrix represents an

n

n

-dimensional rotation between two vectors that is functionally equivalent to the Householder reflection. This study introduces a one-parameter family of unitary transforms, termed the

θ

\theta

transform, which encompasses the transform by the Palais matrix, the Householder reflection, and their unitary extensions. Furthermore, we define the

θ

∠

{\theta }_{\angle }

transform, a variant of the

θ

\theta

transform featuring bounded component norms. It is demonstrated that the

θ

∠

{\theta }_{\angle }

transform is computationally efficient and backward stable when one of the vectors has the “one-hot” structure, making it highly valuable for matrix decompositions such as the QR decomposition. In addition, the

θ

\theta

transform exhibits additional characteristics, including its convergence to the identity and the rowwise structure of its backward error.
Differences in Knowledge, Attitude, and Practice of The Community Parrots in Ternate and Sofifi, North Maluku
Authors: Ramadani Annisa , Setia Tatang Mitra , Mangunjaya Fachruddin M. , Siregar Benny A. , Basalamah Fitriah 
Published: September 2024

Abstract The community's habit of owning wild animals is still ongoing until now. This has become one of the threats to the existence of wildlife in their natural habitat. Parrots, with their ability to imitate surrounding sounds, have become a popular pet choice. Therefore, the purpose of this study is to determine the influence of knowledge, attitudes, and practices about parrots on the profile of the community. The study differentiates between those who owner bird and those who do not. Data collection was conducted for two months in Ternate and Sofifi, North Maluku. The method used was purposive sampling, interviewing as many as 104 respondents who had been determined. The interview data was processed into multiple linear regression values and canonical correlations. The results of this research identified that the majority of those who owned parrots were aged between 42–57 (36%); female (52%); with high school graduates (46%); and engaged in various professions, such as housewives or entrepreneurs (71%). On the other hand, those who were non-owner parrots were dominated by individuals aged 10–25 (46%); male (65%); with undergraduate degrees (62%); and categorized as students (38%). The results of this study show that knowledge and attitudes have an influence on education, profession, and age of the community on the topic of curly-billed bird maintenance. Abstrak Kebiasaan masyarakat memiliki satwa liar masih berlangsung hingga sekarang. Hal ini menjadi salah satu ancaman terhadap keberadaan satwa liar di habitat aslinya. Burung paruh bengkok memiliki kemampuan meniru suara di sekitarnya, dan menjadi satwa liar yang populer sebagai peliharaan. Oleh karena itu, tujuan penelitian ini adalah untuk mengetahui pengaruh pengetahuan, sikap, dan kesadaran tentang pemeliharaan burung paruh bengkok terhadap profil masyarakat. Studi ini membedakan, antara masyarakat yang memelihara burung dan yang tidak. Pengumpulan data dilakukan selama dua bulan di Kota Ternate dan Sofifi, Maluku Utara. Metode yang digunakan purposive sampling, mewawancarai sebanyak 104 responden yang telah ditentukan. Data wawancara tersebut diolah menggunakan software SPSS 22.0 untuk memperoleh nilai regresi linier berganda dan kolerasi kanonikal. Hasil penelitian, mengidentifikasi bahwa mayoritas dari mereka yang memiliki burung paruh bengkok berusia antara 42–57 (36%); berjenis kelamin perempuan (52%); tingkat pendidikan SMA (46%); dan memiliki profesi lainnya, seperti ibu rumah tangga atau pengusaha (71%). Di sisi lain, masyarakat yang tidak memelihara burung paruh bengkok, didominasi yang berusia 10–25 (46%); berjenis kelamin laki-laki (65%); tingkat pendidikan sarjana (62%); dan lebih ddidominasi oleh pelajar/mahasiswa (38%). Hasil penelitian ini menunjukkan bahwa pengetahuan dan sikap memiliki pengaruh dengan pendidikan, profesi, dan usia masyarakat terhadap topik pemeliharaan burung paruh bengkok.
Diversity of Diurnal Butterflies (Lepidoptera) in Three Different Habitats in Batutegi Protected Forest, Lampung
Authors: Ruslan Hasni , Sumayyah Sumayyah , Darmawan Reza Taufiq , Murti Alena Puspa , Cahyani Regitha , Birowo Wirayudho 
Published: September 2024

AbstractBatutegi protected forest has various ecosystems that are habitat for butterfly species despite being largely unexplored. This study aimed to investigate the diversity of diurnal butterflies in three different habitats of Batutegi Protected Forest, Lampung. Sampling using exploration methods was conducted in forest, river, and swamp habitat. The results showed that swamp habitat had 28 species, river habitat had 19 species, and forest habitat had 20 species. Shannon-Wiener diversity index for all habitat was at moderate level. Hutchinson's t-test results showed diversity index between three habitats was significantly different. Evenness index was at high level. The Nymphalidae family had the greatest number of species and individuals, while Lycaenidae and Riodinidae had the least. Eurema hecabe was found the highest in swamp vegetation. Cupha erymanthis was found the highest in river vegetation. Euthalia monina was found the highest in forest vegetation. Two protected species, Trogonoptera brookiana and Troides helena, were observed. Butterfly diversity was affected by habitat condition. This study can serve as fundamental reference in determining vegetation suitability for stabilizing Batutegi Protected Forest for educational and ecotourism purposes.AbstrakHutan Lindung Batutegi memiliki beragam ekosistem yang menjadi habitat spesies kupu-kupu. Penelitian ini bertujuan untuk mengetahui keanekaragaman jenis kupu-kupu di tiga habitat Hutan Lindung Batutegi, Lampung. Pengambilan data dilakukan dengan metode eksplorasi di habitat rawa, sungai dan hutan. Jumlah spesies kupu-kupu ditemukan terbanyak pada habitat rawa sebanyak 28 spesies, spesies kupu-kupu di habitat hutan sebanyak 20 spesies, dan di habitat sungai sebanyak 19 spesies. Komposisi spesies kupu-kupu yang terdapat di habitat rawa dan sungai memiliki tingkat kesamaan yang tinggi. Indeks keanekaragaman kupu-kupu pada tiga habitat tergolong sedang. Hasil uji Hutchinson menunjukkan perbedaan bermakna antar habitat. Indeks kemerataan kupu-kupu di tiga habitat bernilai tinggi. Famili Nymphalidae memiliki spesies dan individu terbanyak, sedangkan famili Lycaenidae dan Riodinidae paling sedikit. Eurema hecabe ditemukan terbanyak di habitat rawa. Cupha erymanthis ditemukan terbanyak di habitat sungai. Euthalia monina ditemukan terbanyak di habitat hutan. Terdapat dua spesies kupu-kupu yang dilindungi, yaitu Troides helena dan Trogonoptera brookiana. Keanekaragaman kupu-kupu dipengaruhi oleh kondisi habitat. Penelitian ini dapat digunakan sebagai dasar pertimbangan kesesuaian habitat yang perlu dipertahankan untuk menyeimbangkan daerah kawasan Hutan Lindung Batutegi sebagai sarana edukasi dan ekowisata.
Detection of KPC-3 producing Escherichia coli ST410 in Volos, Greece
Authors: Chatzidimitriou Maria , Tsolakidou Pandora , Kyriazidi Maria Anna , Mitka Stella 
Published: September 2024

AbstractEscherichia coli A382 was isolated in July 2024 from a positive blood culture obtained from the central venous catheter of a male patient undergoing chemotherapy at the Hospital of Volos, Thessaly, Greece. Whole-genome sequencing analysis revealed that the isolate A382 is E. coli belonging to the ST410 high-risk clone, which co-harbors the blaKPC-3 and blaSHV-182 genes on an IncX3 plasmid. It also harbors blaTEM-1 and has five replicons, as follows: IncX3, IncQ1, CoIRNAI, IncF1A, and IncFIB. Complete genome analysis revealed that E. coli A382 isolate carries a range of virulence factors (iutA, iucC, fimH, fdeC, yehA, yehD, yehC, yehB, cgs, ahha, ccI, hlyE, papC, irp2, fyuA, lpfA, and nlpl) and many other non-beta-lactam resistance determinants, including dfrA14 and sul2, but it is susceptible to aminoglycosides, nitrofurantoin, tigecycline, colistin and ceftazidime-avibactam. In conclusion in this study, we describe the phenotypic and genome characteristics of an extensively drug-resistant E. coli ST410.