bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reperfusion of occluded branch retinal arteries by transluminal Nd:YAG laser embolysis combined with intravenous thrombolysis of urokinase
Authors: Chai Fang , Du Shanshuang , Zhao Xiquan , Wang Runsheng 
Published: November 2017

Purpose: To report successful treatment with transluminal Nd:YAG laser embolysis (TYE) combined with urokinase thrombolysis for reperfusion of occluded branch retinal arteries with visible emboli.
Methods: A total of 34 eyes from 34 patients with acute, severe vision loss secondary to a branch retinal artery occlusion with visible emboli and retinal whitening were examined. Each patient was administered TYE therapy, which focused on the embolus, using an ocular contact lens; a 0.3–0.9 mJ laser pulse was delivered directly and gradually according to the reaction. Fundus photographs and fundus fluorescein angiography (FFA) were obtained before and immediately after the laser treatment. All patients received urokinase thrombolysis therapy drops intravenously for 5 days at 10–20 u/d. The follow-up period ranged from 6 to 14 months after therapy. The morphological characteristics of FFA associated with obstruction recovery of arterial fluorescence filling and visual function were analyzed.
Results: After TYE therapy, FFA examinations showed that the retinal artery and its branches exhibited completely restored blood flow without obstruction in 13 eyes, accounting for 38.2% of the cases. The blood flow was mostly recovered in 11 eyes (32.4% of patients). FFA examinations following the combined intravenous urokinase thrombolysis therapy showed that the retinal artery and its branches exhibited completely restored blood flow after obstruction in 16 eyes (47.1% of patients). The blood flow was mostly recovered in 15 eyes (44.1% of patients).
Conclusion: TYE combined with urokinase thrombolysis is effective for reperfusion of occluded branch retinal arteries and improving visual recovery in patients with visible emboli.
Dual‐band substrate integrated waveguide bandpass filter utilising complementary split‐ring resonators
Authors: Zhang Hao , Kang Wei , Wu Wen 
Published: November 2017

A novel dual‐band substrate integrated waveguide (SIW) bandpass filter (BPF) based on complementary split‐ring resonators (CSRRs) is proposed. It consists of an SIW dual‐mode cavity loaded by two additional CSRRs on its top layer. Both TE102 and TE201 modes in the cavity can be excited by the proper positions of the feeding lines. Two additional CSRRs are etched on the top layer coupled with the TE102 and TE201 modes, respectively, to achieve the dual‐frequency operation. Four transmission zeros are generated in the vicinity of the passbands to improve the selectivity. To validate the design concept, a dual‐band SIW BPF operating at 7.89 and 8.89 GHz is designed, simulated and measured. The measured results are in good agreement with the simulations.
0.058 mm2 13 Gbit/s inductorless analogue equaliser with low‐frequency equalisation compensating 15 dB channel loss
Authors: Balachandran Arya , Chen Yong , Choi Pilsoon , Boon Chirn Chye 
Published: November 2017

An inductorless 13 Gbit/s analogue equaliser with an additional low‐frequency equalisation (LFEQ) to counter the low‐frequency channel losses is presented. An active feedback topology for the proposed equaliser together with negative capacitance circuit is used to extend the bandwidth to compensate a 15 dB channel loss at Nyquist. The LFEQ improves the measured data jitter of the conventional equaliser from 0.41 to 0.12 UI, for a pseudorandom binary sequence of 231 − 1. The proposed prototype was implemented in 65 nm CMOS, occupying active area of merely 0.058 mm2. It exhibits a power efficiency of 1.07 mW/Gitb/s under a supply voltage of 1.2 V and a BER < 10−12.
Influence of untested winding in FRA test for winding diagnosis
Authors: Li Cheng X. , Zhu Tian Y. , Xia Qi , Yao Chen G. , Zhao Zhong Y. 
Published: November 2017

Frequency response analysis (FRA) is a usual method for diagnosing winding, core, insolation faults in transformer. By the change of the FRA traces, the faults can be detected. This study presents the interpretation on influence of untested winding's fault. A special power transformer of rating 10 kV/400 V, three‐phase, 50 Hz, YNyn0 has been developed for carrying out FRA tests by practically simulated various winding faults in different phase. The windings of phase ‘A’ and phase ‘B’ on HV side are tested with different types of faults, respectively. The results of these experiments are displayed and discussed. It shows that when the untested winding is shorted, the influence of the inductive fault can be eliminated.
Emerging Roles for von Willebrand Factor in Cancer Cell Biology
Authors: Preston Roger , Robson Tracy , O'Donnell James , O'Sullivan Jamie 
Published: November 2017

Abstractvon Willebrand factor (VWF) is a complex multimeric plasma glycoprotein that plays critical roles in normal hemostasis. However, additional novel roles for VWF in modulating cancer cell biology, and in particular tumor metastasis, have recently been reported. Markedly elevated plasma VWF levels were associated with advanced tumor stage and metastatic disease. These observations have raised the question of whether VWF may be involved in regulating tumor progression. Interestingly, novel findings indicate that VWF is expressed by a variety of tumor cells of nonendothelial origin. Critically, tumor cells that exhibit de novo acquired VWF expression demonstrate enhanced binding to endothelial cells (EC) and platelets, and increased extravasation through EC barriers. Furthermore, in vitro studies have shown that VWF can bind a variety of different tumor cells mediated by specific receptors expressed on the tumor cell surface. The concept that VWF is important in modulating tumor metastasis is further supported by in vivo experiments demonstrating that antibody-mediated VWF inhibition significantly attenuated murine metastasis. Intriguingly, however, VWF binding to specific human tumor cell lines results in apoptosis. In this study, the authors provide an overview of recent advances supporting a role for VWF in regulating multiple aspects of cancer cell biology.
Alloantibodies in von Willebrand Disease
Authors: Franchini Massimo , Mannucci Pier 
Published: November 2017

Abstractvon Willebrand disease (VWD), the most commonly known inherited bleeding disorder, is caused by a partial (type 1) or total (type 3) deficiency or dysfunction (type 2) of von Willebrand factor (VWF). Its management encompasses the prevention or treatment of bleeding by raising endogenous VWF levels using a synthetic agent, such as desmopressin, or providing exogenous VWF concentrates. The development of inhibitory alloantibodies against VWF is a rare but often severe complication encountered during the treatment of type 3 VWD, which is associated with a lack of hemostatic response to infused VWF concentrates and more rarely with allergic, even anaphylactic, reactions. This narrative review will focus on the characteristics of such alloantibodies and their management, which can be very challenging for physicians operating at hemophilia treatment centers.
Laparoscopic Inguinal Hernia Repair in Infants and Children: State-of-the-Art Technique
Authors: Tam Paul , Chan Ivy 
Published: November 2017

AbstractPediatric inguinal hernia is one of the most common surgical conditions with open herniotomy being the gold standard of treatment. With the advances of laparoscopic surgery, it has emerged as an alternative to open repair with reported good results. However, laparoscopic hernia repair is not yet a routine procedure in many centers, and debate of laparoscopic versus open repair still exists. After 20 years of development of laparoscopic hernia repair, different techniques have been described with no consensus on the standard technique right now. This article reviews the latest updates of laparoscopic repair from the current evidence in the literature. Laparoscopic management of hernia in premature/small infants and hernia incarceration are also discussed here.
Perianal Dermatitis, Its Incidence, and Patterns of Topical Therapies in a Level IV Neonatal Intensive Care Unit
Authors: Witsberger Emily , Cottrell Lesley , Kiefer Autumn , Yossuck Panitan , Malik Anuj 
Published: November 2017

Objective To define the incidence of perianal dermatitis (PD) and determine the usage pattern and cost efficacy of diaper products among neonates admitted to a level IV neonatal intensive care unit (NICU) including those with a diagnosis of neonatal abstinence syndrome (NAS).
Methods A retrospective cohort study to evaluate neonates with PD based on number of orders for Aquaphor, Bagbalm, Desitin, Flanders, or Nystatin. Various demographic and clinical parameters were recorded. Usage patterns of these five products were analyzed, and their costs estimated. Subgroup analysis was performed among infants with NAS.
Results Of 1,241 admissions, 56.2% had at least one diaper product ordered during their NICU stay, while 52.6% had multiple products ordered. Only 23.0% of all neonates had appropriate documentation of PD. The most common product ordered first was Aquaphor (64.3%), followed by Desitin (19.2%). Note that 86% term NAS infants had PD compared with 28% term non-NAS infants. The estimated product cost was $14,139 over 2 years, averaging $20 per patient.
Conclusion Over half of NICU neonates were exposed to one or more diaper products, usually without documented PD diagnosis. Term NAS infants had three times higher incidence of PD than term non-NAS infants. The cost of diaper product use was significant, and possibly underestimated due to lack of documentation.
Knee Position during Surgical Wound Closure in Total Knee Arthroplasty: A Review
Authors: Faour Mhamad , Sodhi Nipun , Khlopas Anton , Piuzzi Nicolas , Stearns Kim , Krebs Viktor , Higuera Carlos , Mont Michael 
Published: November 2017

AbstractStudy areas concerning maximizing knee range of motion (ROM) following total knee arthroplasty (TKA) have come under focus by surgeons. Among the perioperative factors that were identified to affect ROM after TKAs is knee position during surgical wound closure. Therefore, the aim of this study was to review the impact of knee position during TKA wound closure on: (1) postoperative ROM, (2) wound-related complications, (3) Knee Society Score (KSS), (4) postoperative pain, and (5) muscle strength and home functional recovery. A literature search was performed using PubMed, Ovid, and Google Scholar using various combinations of the following search terms: “wound closure,” “knee position,” “surgical closure,” and “knee arthroplasty.” The studies were evaluated for outcomes after TKA and stratified based on the knee position at surgical closure. After application of inclusion and exclusion criteria, seven studies were analyzed. The total number of patients included was 516 patients (259 patients in the flexion group and 257 patients in the full extension group). Based on the reviewed literature, wound closure in flexion was associated with significant improvement in ROM recovery at earlier follow-ups after TKA (four positive and three neutral studies), better early postoperative pain scores (two positive and one neutral study), and faster physical recovery (two positive studies) (better muscle strength and early achievement of physical therapy milestones) compared with wound closure in extension. No difference was found between wound closure in flexion compared with closure in extension in terms of long-term ROM recovery, long-term postoperative pain scores, wound-related complications (seven neutral studies), knee function measured by KSS (five neutral studies), or patient satisfactions after TKA. Although the current review is limited by the number of studies that are available in the literature, it demonstrates that overall, compared with extension, surgical wound closure in flexion may provide better ROM, faster recovery, comparable patient satisfaction, and no risk of higher wound complications.
Implementation of an optical diagnosis strategy saves costs and does not impair clinical outcomes of a fecal immunochemical test-based colorectal cancer screening program
Authors: Vleugels Jasper , Greuter Marjolein , Hazewinkel Yark , Coupé Veerle , Dekker Evelien 
Published: November 2017

Abstract
Background and study aims In an optical diagnosis strategy, diminutive polyps that are endoscopically characterized with high confidence are removed without histopathological analysis and distal hyperplastic polyps are left in situ. We evaluated the effectiveness and costs of optical diagnosis.
Methods Using the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model, we simulated biennial fecal immunochemical test (FIT) screening in individuals aged 55 – 75 years. In this program, we compared an optical diagnosis strategy with current histopathology assessment of all diminutive polyps. Base-case assumptions included 76 % high-confidence predictions and sensitivities of 88 %, 91 %, and 88 % for endoscopically characterizing adenomas, sessile serrated polyps, and hyperplastic polyps, respectively. Outcomes were colorectal cancer burden, number of colonoscopies, life-years, and costs.
Results Both the histopathology strategy and the optical diagnosis strategy resulted in 21 life-days gained per simulated individual compared with no screening. For optical diagnosis, €6 per individual was saved compared with the current histopathology strategy. These cost savings were related to a 31 % reduction in colonoscopies in which histopathology was needed for diminutive polyps. Projecting these results onto the Netherlands (17 million inhabitants), assuming a fully implemented FIT-based screening program, resulted in an annual undiscounted cost saving of € 1.7 – 2.2 million for optical diagnosis.
Conclusion Implementation of optical diagnosis in a FIT-based screening program saves costs without decreasing program effectiveness when compared with current histopathology analysis of all diminutive polyps. Further work is required to evaluate how endoscopists participating in a screening program should be trained, audited, and monitored to achieve adequate competence in optical diagnosis.
ICG-Fluoreszenzcholangiografie im Vergleich zur konventionellen Röntgencholangiografie im Rahmen einer laparoskopischen Cholezystektomie
Authors: Pax Viktoria , Schneider-Koriath Sylke , Scholz Martin , Wießner Reiko , Ludwig Kaja 
Published: November 2017

Zusammenfassung
Einleitung Die Inzidenzrate einer Gallengangverletzung (BDI) im Rahmen einer laparoskopischen Cholezystektomie (LC) beträgt 0,3%. Eine routinemäßige Anwendung der intraoperativen Röntgencholangiografie (IOC) wird jedoch aufgrund der zusätzlichen Kosten und der Strahlenbelastung kontrovers diskutiert. Ziel dieser Studie war die klinische Evaluation der Fluoreszenzcholangiografie (FC).
Material und Methoden Die vorliegende prospektive Studie umfasste 230 Patienten, die sich einer LC unterzogen haben. 170 Patienten erhielten sowohl eine FC als auch eine IOC entsprechend einem standardisierten Protokoll. In weiteren 60 Fällen wurden die Ergebnisse der FC mit einer LC ohne eine simultane Cholangiografie verglichen. Anschließend erfolgte die Analyse der Daten hinsichtlich des zeitlichen Aufwands und der Identifikation von biliären Strukturen.
Ergebnisse Das Durchschnittsalter und der Durchschnitts-BMI betrugen 54,4 ± 15,7 Jahre und 27,9 ± 5,7 kg/m² bei einer mittleren Operationszeit von 67,6 ± 23,3 min. Der zeitliche Aufwand der FC war dabei deutlich geringer als derjenige der IOC (1,5 ± 0,9 vs.7,3 ± 5,0 min). Die Detektionsraten für Ductus cysticus (DC) sowie Ductus hepaticus communis (DHC) im Rahmen einer FC betrugen vor Dissektion am Calot-Dreieck 67,5 bzw. 66,2% und währenddessen 95,9 bzw. 71,2%. Ein BMI > 25 kg/m² und männliches Geschlecht reduzierten signifikant die Darstellbarkeit der Strukturen. Der Nachweis einer galligen Sekretion aus dem Gallenblasenbett gelang in 3 Fällen (1,8%) durch eine FC. In 2 Fällen (1,2%) wurde der Abgang des DC aus dem Ductus hepaticus dexter durch IOC dargestellt und in einem Fall (0,6%) bereits durch FC beschrieben. Intraduktale Aussparungen ließen sich bei 9 Patienten (5,3%) mithilfe einer IOC und bei einem Patienten (0,6%) durch eine FC nachweisen. Bei Verzicht auf eine zusätzliche intraoperative Diagnostik betrugen die Detektionsraten von DC und DHC60,0 bzw. 43,3%, mithilfe einer FC80,0 bzw. 53,3%. Dementsprechend bestätigten die Operateure in 70,0% der Fälle eine Erhöhung der operativen Sicherheit durch eine FC.
Schlussfolgerung Die FC ist eine einfache, nicht invasive Methode zur Echtzeitdarstellung der Gallengangsanatomie während einer LC. Eine schnelle Identifizierung von anatomischen Normvarianten und galliger Sekretion aus dem Gallenblasenbett erhöht die operative Sicherheit und ermöglicht die simultane Versorgung. Bei Vorliegen einer intraabdominalen Adipositas besitzt die Untersuchung eine limitierte Aussagekraft.
Zur Unfallwahrscheinlichkeit von Senioren bei der Nutzung von
E-Bikes
Authors: Weiss Raphael , Juhra Christian , Wieskötter Britta , Weiss Udo , Jung Susanne , Raschke Michael 
Published: November 2017

Zusammenfassung
Hintergrund Deutschland ist eine Radfahrnation mit über 70 Mill.
Fahrrädern. Bedingt durch die technische Weiterentwicklung wurden im Jahr 2010
deutschlandweit bereits 200 000 E-Bikes (Oberbegriff für elektrobetriebene
Fahrräder, beinhaltet auch Pedelecs) verkauft, 2013 waren dies bereits 410 000.
Aktuell werden deutschlandweit mehr als 1,6 Mill. Elektrofahrräder genutzt. Eine
der größten Nutzergruppen sind Senioren. Unfallforscher befürchten ein erhöhtes
Unfall-/Verletzungsrisiko.
Methode Ein Jahr lang wurden alle Radverkehrsunfälle, speziell die
Elektrofahrradunfälle unter Beteiligung von Senioren, in 23 Krankenhäusern des
TraumaNetzwerks NordWest und der örtlich zuständigen Polizeibehörden erhoben und
analysiert.
Ergebnisse Ein Vergleich der Elektrofahrrad fahrenden Senioren mit der
Gruppe der ebenfalls elektrounterstützt Rad fahrenden Jüngeren ergab im ersten
Ansatz ein höheres Verletzungsrisiko. Die weitere vergleichende Analyse der
schwerverletzten Senioren, die ein elektrounterstütztes Fahrrad fuhren, mit
denen, die ein konventionelles Fahrrad nutzten, widersprach dem jedoch. Eine
statistische Signifikanz blieb aus. Die Unfallwahrscheinlichkeit erhöhte sich
mit dem Alter, nicht jedoch mit dem Fahrradtyp.
Schlussfolgerung Unfallvermeidend könnten, neben einem spezifischen
Fahrtraining, medizinische Vorsorgeuntersuchungen zur Früherkennung von
Leistungseinbußen, speziell im Bereich kognitiver Verarbeitungsprozesse und des
Gleichgewichts, wirken. Sie sollten zukünftig selbstverständlicher Bestandteil
der Gesundheitsvorsorge und damit der Beratungsleistung der niedergelassenen
Ärzte sein.
The prognostic value of physiological and physical characteristics in youth soccer: A systematic review
Authors: Murr Dennis , Raabe Johannes , Höner Oliver 
Published: November 2017

AbstractTalent identification and selection in soccer is typically based on subjective evaluations of experienced coaches. Recently, there has been a trend to complement these subjective assessments with objective tests. However, there is currently no comprehensive overview of the prognostic relevance of objective measurements in youth soccer. Therefore, the primary purpose of the current study was to systematically review published empirical studies related to the prognostic relevance of physiological (e.g. endurance and speed) and physical characteristics (i.e. height and weight). Of 6876 initially identified studies, nine articles were included. In those studies, endurance (nine studies), change of direction (seven), height (seven), and weight (seven) received the most meaningful consideration within the literature. In regard to physiological predictors, between 16 and 29 effect sizes were tested for endurance, sprint, and change of direction, and about half of them were found to be significant with small to moderate effects (0.37 ≤ Mdn(d) ≤ 0.57). In addition, while only investigated in two studies all tested effect sizes for repeated sprint ability were found to be significant. Despite their frequent consideration in the literature, low numbers of significant effect sizes (≤ 26%) and magnitude (0.23 ≤ Mdn(d) ≤ 0.29) were found for the physical predictors height and weight. Overall, results appear to be dependent on the respective study design and, in particular, moderator variables (i.e. soccer development stage, performance level T1/T2, prognostic period, and sample size). Consequently, additional research seems warranted to more comprehensively investigate the predictive relevance of the individual characteristics using more homogeneous study designs.
Improved cognitive performance in preadolescent Danish children after the school‐based physical activity programme “FIFA 11 for Health” for Europe – A cluster‐randomised controlled trial
Authors: Lind Rune Rasmussen , Geertsen Svend Sparre , Ørntoft Christina , Madsen Mads , Larsen Malte Nejst , Dvorak Jiri , Ritz Christian , Krustrup Peter 
Published: November 2017

AbstractObjective: Recent studies have shown promising effects of physical activity on cognitive function, but there is a need to investigate this link in real‐life settings such as schools. Hence, the objective of the present pilot study was to investigate whether the school‐based physical activity programme “FIFA 11 for Health” for Europe could improve cognitive performance in preadolescent Danish children. Methods: The pilot study used an 11‐week cluster‐randomised intervention study design. School classes were randomly assigned to either a control group (CG) (n = 93 children, age = 11.8, s = 0.2 years), which performed the obligatory daily school‐based physical activity (5 × 45 minutes per week); or an intervention group (IG) (n = 838 children, age = 11.9, s = 0.4 years), which substituted 2 × 45 minutes per week of the daily school physical activity with the “FIFA 11 for Health” for Europe programme. The programme combines small‐sided football games, drills and health education. Cognitive performance was evaluated at baseline and follow‐up. Results: The IG improved their cognitive performance compared to the CG for psychomotor function (56, sx– = 22 ms, p < .001), attention (39, sx– = 17 ms, p = .012) and working memory (79, sx– = 35 ms, p = .020). Conclusion: This pilot study provides evidence that the school‐based physical activity programme “FIFA 11 for Health” for Europe can improve cognitive performance in preadolescent Danish schoolchildren. Future studies should attempt to disentangle the effects of “FIFA 11 for Health” for Europe on cognitive performance by investigating the characteristics of the programme's physical activity.
The Economic and Health Effects of the 2014 Chemical Spill in the Elk River, West Virginia
Authors: Guilfoos Todd , Kell Dalton , Boslett Andrew , Hill Elaine L 
Published: November 2017

AbstractIn January 2014, Freedom Industries spilled 4‐methylcyclohexylmethanol, a chemical foaming agent used in coal processing, from a storage facility into the Elk River in West Virginia. This chemical spill, one of the most significant in U.S. history, adversely affected the drinking water supply of over 300,000 individuals in the Charleston, West Virginia Metropolitan area. We use synthetic control methods to estimate the casual effects on macro‐economic growth and infant health outcomes from this water crisis. We find a significant decrease in 5‐minute Apgar Scores, a measure of how babies fare in the birthing process and outside of the womb, after the chemical spill. We do not find significant effects for infant birthweight or gestational age. We find a statistically insignificant decrease of per capita GDP in the Charlestown, West Virginia area compared to the synthetic control of 3% two years after the chemical spill.