bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linked color imaging improves the visibility of colorectal polyps: a video study
Authors: Yoshida Naohisa , Naito Yuji , Murakami Takaaki , Hirose Ryohei , Ogiso Kiyoshi , Inada Yutaka , Dohi Osamu , Kamada Kazuhiro , Uchiyama Kazuhiko , Handa Osamu , Konishi Hideyuki , Siah Kewin , Yagi Nobuaki , Fujita Yasuko , Kishimoto Mitsuo , Yanagisawa Akio , Itoh Yoshito 
Published: June 2017

Abstract
Background/study aim Linked color imaging (LCI) by a laser endoscope (Fujifilm Co, Tokyo, Japan) is a novel narrow band light observation. In this study, we aimed to investigate whether LCI could improve the visibility of colorectal polyps using endoscopic videos.
Patients and methods We prospectively recorded videos of consecutive polyps 2 – 20 mm in size diagnosed as neoplastic polyps. Three videos, white light (WL), blue laser imaging (BLI)-bright, and LCI, were recorded for each polyp by one expert. After excluding inappropriate videos, all videos were evaluated in random order by two experts and two non-experts according to a published polyp visibility score from four (excellent visibility) to one (poor visibility). Additionally, the relationship between polyp visibility scores in LCI and various clinical characteristics including location, size, histology, morphology, and preparation were analyzed compared to WL and BLI-bright.
Results We analyzed 101 colorectal polyps (94 neoplastic) in 66 patients (303 videos). The mean polyp size was 9.0 ± 8.1 mm and 54 polyps were non-polypoid. The mean polyp visibility scores for LCI (2.86 ± 1.08) were significantly higher than for WL and BLI-bright (2.53 ± 1.15, P < 0.001; 2.73 ± 1.47, P < 0.041). The ratio of poor visibility (score 1 and 2) was significantly lower in LCI for experts and non-experts (35.6 %, 33.6 %) compared with WL (49.6 %, P = 0.015, 50.5 %, P = 0.046). The polyp visibility scores for LCI were significantly higher than those for WL for all of the factors. With respect to the comparison between BLI-bright and WL, the polyp visibility scores for BLI-bright were not higher than WL for right-sided location, < 10 mm size, sessile serrated adenoma and polyp histology, and poor preparation. For those characteristics, LCI improved the lesions with right-sided location, SSA/P histology, and poor preparation significantly better than BLI.
Conclusions LCI improved polyp visibility compared to WL for both expert and non-expert endoscopists. It is useful for improving polyp visibility in any location, any size, any morphology, any histology, and any preparation level.Study registration: UMIN000013770
Stellenwert der Immunonkologie bei der Therapie des Urothelkarzinoms
Authors: Retz Margitta , Tauber Robert , Horn Thomas 
Published: June 2017

ZusammenfassungIm November 2016 wurden Studiendaten zur Zweitlinientherapie des metastasierten Urothelkarzinoms mit dem PD-1-Antikörper Pembrolizumab publiziert, die einen Vorteil im Gesamtüberleben gegenüber einer konventionellen Chemotherapie zeigen. Andere PD-1/PD-L1-Inhibitoren befinden sich in fortgeschrittenen klinischen Studien. Diese Substanzklasse wird ab der für 2017 erwarteten Zulassung in dieser Therapiesituation der neue Standard sein und damit die bisher empfohlene Chemotherapie mit Vinflunin ablösen. Aktuelle Studien überprüfen derzeit den Einsatz von PD-1/PD-L1 gerichteten Substanzen auch in der Erstlinientherapie des metastasierten Urothelkarzinoms. Dabei werden verschiedene Therapiestrategien verfolgt: Monotherapien mit PD-1/PD-L1-Inhibitoren sowie deren Kombinationen mit CTLA-4-Inhibitoren oder konventioneller Chemotherapie. Erste Studiendaten werden für Ende 2017 erwartet. Ein neuer Therapieansatz verfolgt den Einsatz von Checkpoint-Inhibitoren in der perioperativen Behandlung bei Patienten mit einem muskelinvasiven Urothelkarzinom nach chirurgischer R0-Resektion (Radikale Zystektomie oder Nephroureterektomie). Zwei internationale Phase-III-Studien überprüfen derzeit eine adjuvante Immuntherapie mit Nivolumab oder Atezolizumab. Die Studienrekrutierung wird voraussichtlich Mitte 2018 beendet sein.
Neurodermitis: Haut in der Defensive
Authors: Staubach-Renz Petra 
Published: June 2017

SummarySchubweiser Verlauf, Überreaktion auf hautreizende Trigger und atopische Disposition kennzeichnen nahezu alle Neurodermitisverläufe. Fast immer zeigen sich dabei eine rezidivierende Dermatitis, Juckreiz, trockene Haut und typische Prädilektionsstellen unter anderem an Arm- und Beinbeugen. Die Leitlinien umfassen alle Optionen zum Management der Neurodermitis einschließlich Diagnostik, Therapieoptionen und Ernährungsberatung.
Religion in European constitutions – cases of different secularities
Authors: Schnabel Annette , Behrens Kathrin , Grötsch Florian 
Published: June 2017

ABSTRACT
This article explores how religion and the public legal domains of modern societies in the EU-member states are institutionally interconnected. We focus our analysis on how religion, religiosity and religious organisations are integrated and regulated in European constitutions. Our analysis is guided by two sociological theories concerning the development of modern institutional arrangements: (a) neo-institutionalism, emphasising the influence of world culture which leads to institutional isomorphism as the adaption of worldwide shared scripts; (b) path dependency, emphasising the emergence of institutional arrangements as path depending on particular power relations and historical events. From neo-institutionalism, we expect to find similarities in more recent constitutions while theories of path dependency indicate similarities only in cases of similar historical events or power relations. In applying an explorative, quantitative document analysis of a unique data set of constitutions, we detect similarities and differences concerning religion in the constitutional texts. Our analysis establishes religion as a multi-dimensional issue that is regulated in quite different ways in different states. We demonstrate that neo-institutionalism is valid only on the mere formal level of the composition of the constitutions of the EU-member states.
Effect of dual‐attention task on attack and defensive actions in fencing
Authors: Gutiérrez‐Davila Marcos , Rojas F. Javier , Gutiérrez‐Cruz Carmen , Navarro Enrique 
Published: June 2017

AbstractThe objectives of this study were to investigate the effect that the presence of two stimuli that require two different responses (dual‐attention) has both, on offensive reaction‐response time to a light stimulus, and on defensive response time when the stimulus is a real fencing attack. Twenty‐five elite fencers and a fencing master were included in the study. The equipment included four force plates adapted to a scaffold that served as a fencing piste. Two force plates were placed, at the start position, under the fencer's feet and another two plates were placed under the master's feet. The results demonstrate that choice reaction time to visual stimuli increases in dual‐task conditions with respect to simple reaction time, whereas the mean horizontal force tends to decrease in dual‐task. However, when the stimulus was an opponent's movement, dual‐task conditions did not have any effect on the time required to initiate a defensive action. The changes in reaction time when real movements were used as stimuli challenge the validity of the reaction time to visual stimuli paradigm as a predictor of performance in fencing. Also, the results obtained demonstrate that perceptual and attentional processes play a major role in fencer performance in real competition.
CloudNeo: a cloud pipeline for identifying patient-specific tumor neoantigens
Authors: Bais Preeti , Namburi Sandeep , Gatti Daniel M , Zhang Xinyu , Chuang Jeffrey H 
Published: June 2017

Abstract

Summary
We present CloudNeo, a cloud-based computational workflow for identifying patient-specific tumor neoantigens from next generation sequencing data. Tumor-specific mutant peptides can be detected by the immune system through their interactions with the human leukocyte antigen complex, and neoantigen presence has recently been shown to correlate with anti T-cell immunity and efficacy of checkpoint inhibitor therapy. However computing capabilities to identify neoantigens from genomic sequencing data are a limiting factor for understanding their role. This challenge has grown as cancer datasets become increasingly abundant, making them cumbersome to store and analyze on local servers. Our cloud-based pipeline provides scalable computation capabilities for neoantigen identification while eliminating the need to invest in local infrastructure for data transfer, storage or compute. The pipeline is a Common Workflow Language (CWL) implementation of human leukocyte antigen (HLA) typing using Polysolver or HLAminer combined with custom scripts for mutant peptide identification and NetMHCpan for neoantigen prediction. We have demonstrated the efficacy of these pipelines on Amazon cloud instances through the Seven Bridges Genomics implementation of the NCI Cancer Genomics Cloud, which provides graphical interfaces for running and editing, infrastructure for workflow sharing and version tracking, and access to TCGA data.

Availability and implementation
The CWL implementation is at: https://github.com/TheJacksonLaboratory/CloudNeo. For users who have obtained licenses for all internal software, integrated versions in CWL and on the Seven Bridges Cancer Genomics Cloud platform (https://cgc.sbgenomics.com/, recommended version) can be obtained by contacting the authors.

Supplementary information
Supplementary data are available at Bioinformatics online.
Surgeon-Level Variability in Outcomes, Cost, and Comorbidity Adjusted-Cost for Elective Lumbar Decompression and Fusion
Authors: Chotai Silky , Sivaganesan Ahilan , Sielatycki John A , Archer Kristin R , Call Richard , McGirt Matthew J , Devin Clinton J 
Published: June 2017

Abstract

BACKGROUND
The costs and outcomes following degenerative spine surgery may vary from surgeon to surgeon. Patient factors such as comorbidities may increase the health care cost. These variations are not well studied.

OBJECTIVE
To understand the variation in outcomes, costs, and comorbidity-adjusted cost for surgeons performing lumbar laminectomy and fusions surgery.

METHODS
A total of 752 patients undergoing laminectomy and fusion, performed by 7 surgeons, were analyzed. Patient-reported outcomes and 90-d cost were analyzed. Multivariate regression model was built for high-cost surgery. A separate linear regression model was built to derive comorbidity-adjusted 90-d costs.

RESULTS
No significant differences in improvement were found across all the patient-reported outcomes, complications, and readmission among the surgeons. In multivariable model, surgeons #4 (P < .0001) and #6 (P = .002) had higher odds of performing high-cost fusion surgery. The comorbidity-adjusted costs were higher than the actual 90-d costs for surgeons #1 (P = .08), #3 (P = .002), #5 (P < .0001), and #7 (P < .0001), whereas they were lower than the actual costs for surgeons #2 (P = .128), #4 (P < .0001), and #6 (P = .44).

CONCLUSION
Our study provides valuable insight into variations in 90-d costs among the surgeons performing elective lumbar laminectomy and fusion at a single institution. Specific surgeons were found to have greater odds of performing high-cost surgeries. Adjusting for preoperative comorbidities, however, led to costs that were higher than the actual costs for certain surgeons and lower than the actual costs for others. Patients’ preoperative comorbidities must be accounted for when crafting value-based payment models. Furthermore, designing intervention targeting “modifiable” factors tied to the way the surgeons practice may increase the overall value of spine care.
Providing Culturally Sensitive Care for Islamic Patients and Families
Authors: Blankinship Lisa Ann 
Published: June 2017

Abstract
Nurses can expect to care for patients from different cultures and faith traditions and need to develop cultural competence. This article describes what is important in providing culturally and religiously sensitive care to Muslim and Middle Eastern patients. The Crescent of Care Model by Lovering is offered to aid understanding of five key areas of culturally competent care. Jesus' story of the Good Samaritan (Luke 10:25-37) offers guidance for Christian nurses caring for those in need.
The Impact of a Mother’s Emotional Strains and Disclosure of Cancer on Her Child’s Defensiveness and Adjustment to Cancer
Authors: Arabiat Diana H. , Collyer Dorren , Hamdan-Mansour Ayman , Khalil Amani , Darawad Mohammad 
Published: June 2017

Background:
Defensiveness is one of the strategies that children with cancer use against psychosocial difficulties, yet it remains unclear what factors may impact children's use of defensiveness.

Objective:
The aim of this study was to explore the psychological adjustment, including use of defensive behaviors, in children who may or may not be told about the diagnosis of cancer.

Methods:
A total of 58 children and 51 mothers participated in the study. Children answered questionnaires about defensiveness, anxiety, and depression, whereas mothers completed a questionnaire of anxiety, depression, and stress and a question about disclosure of cancer to child.

Results:
Significant differences were found in the defensiveness and depression scores between children with full disclosure and those with no disclosure about their cancer. Although children's adjustment has been directly related to that of their mother's adjustment, we did not find this variable to be a predictor of child's adjustment. The child's defensiveness scores were a strong predictor of child's anxiety and eventually for a high risk for depression.

Conclusions:
Mothers' emotional strains and lack of open disclosure about cancer significantly affect the psychosocial well-being of children.

Implications for Practice:
It is essential for nurses to assess the emotional adjustment and defensiveness strategies that children with cancer use. We believe that nurses caring for children with cancer have a professional responsibility to identify and understand defensive behaviors and other characteristics of psychosocial distress and advocate for psychological interventions that will help mothers and their children cope with cancer.
Probability of Opioid Prescription Refilling After Surgery
Authors: Sekhri Shaina , Arora Nonie S. , Cottrell Hannah , Baerg Timothy , Duncan Anthony , Hu Hsou Mei , Englesbe Michael J. , Brummett Chad , Waljee Jennifer F. 
Published: June 2017

Objective:
We sought to determine the correlation between the probability of postoperative opioid prescription refills and the amount of opioid prescribed, hypothesizing that a greater initial prescription yields a lower probability of refill.

Background:
Although current guidelines regarding opioid prescribing largely address chronic opioid use, little is known regarding best practices and postoperative care.

Methods:
We analyzed Optum Insight claims data from 2013 to 2014 for opioid-naïve patients aged 18 to 64 years who underwent major or minor surgical procedures (N = 26,520). Our primary outcome was the occurrence of an opioid refill within 30 postoperative days. Our primary explanatory variable was the total oral morphine equivalents provided in the initial postoperative prescription. We used logistic regression to examine the probability of an additional refill by initial prescription strength, adjusting for patient factors.

Results:
We observed that 8.67% of opioid-naïve patients refilled their prescriptions. Across procedures, the probability of a single postoperative refill did not change with an increase with initial oral morphine equivalents prescribed. Instead, patient factors were correlated with the probability of refill, including tobacco use [odds ratio (OR) 1.42, 95% confidence interval (CI) 1.23–1.57], anxiety (OR 1.30, 95% CI 1.15–1.47), mood disorders (OR 1.28. 95% CI 1.13–1.44), alcohol or substance abuse disorders (OR 1.43, 95% CI 1.12–1.84), and arthritis (OR 1.21, 95% CI 1.10–1.34).

Conclusions:
The probability of refilling prescription opioids after surgery was not correlated with initial prescription strength, suggesting surgeons could prescribe smaller prescriptions without influencing refill requests. Future research that examines the interplay between pain, substance abuse, and mental health could inform strategies to tailor opioid prescribing for patients.
Does circadian regulation lead to optimal gas exchange regulation?
Authors: Resco de Dios Víctor , Gessler Arthur , Ferrio Juan Pedro , Alday Josu G , Bahn Michael , del Castillo Jorge , Devidal Sébastien , García-Muñoz Sonia , Kayler Zachary , Landais Damien , Martín-Gómez Paula , Milcu Alexandru , Piel Clément , Pirhofer-Walzl Karin , Ravel Olivier , Salekin Serajis , Tissue David T , Tjoelker Mark G , Voltas Jordi , Roy Jacques 
Published: June 2017

SummaryOptimal stomatal theory is an evolutionary model proposing that leaves trade-off Carbon (C) for water to maximise C assimilation (A) and minimise transpiration (E), thereby generating a marginal water cost of carbon gain (λ) that remains constant over short temporal scales. The circadian clock is a molecular timer of metabolism that controlsAand stomatal conductance (gs), amongst other processes, in a broad array of plant species. Here, we test whether circadian regulation contributes towards achieving optimal stomatal behaviour. We subjected bean (Phaseolus vulgaris) and cotton (Gossypium hirsutum) canopies to fixed, continuous environmental conditions of photosynthetically active radiation, temperature and vapour pressure deficit over 48 hours. We observed a significant and self-sustained circadian oscillation inAand in stomatal conductance (gs) which also led to a circadian oscillation inλ. The lack of constant marginal water cost indicates that circadian regulation does not directly lead to optimal stomatal behaviour. However, the temporal pattern in gas exchange, indicative of either maximizingAor of minimizingE, depending upon time of day, indicates that circadian regulation could contribute towards optimizing stomatal responses. More broadly, our results add to the emerging field of plant circadian ecology and show that molecular controls may partially explain leaf-level patterns observed in the field.
Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling
Authors: Fuks Garold , Elgart Michael , Amir Amnon , Zeisel Amit , Turnbaugh Peter J. , Soen Yoav , Shental Noam 
Published: June 2017

AbstractBackgroundMost of our knowledge about the remarkable microbial diversity on Earth comes from sequencing the 16S rRNA gene. The use of next-generation sequencing methods has increased sample number and sequencing depth, but the read length of the most widely used sequencing platforms today is quite short, requiring the researcher to choose a subset of the gene to sequence (typically 16-33% of the total length). Thus, many bacteria may share the same amplified region and the resolution of profiling is inherently limited. Platforms that offer ultra long read lengths, whole genome shotgun sequencing approaches, and computational frameworks formerly suggested by us and by others, all allow different ways to circumvent this problem yet suffer various shortcomings. There is need for a simple and low cost 16S rRNA gene based profiling approach that harnesses the short read length to provide a much larger coverage of the gene to allow for high resolution, even in harsh conditions of low bacterial biomass and fragmented DNA.ResultsThis manuscript suggests Short MUltiple Regions Framework (SMURF), a method to combine sequencing results from different PCR-amplified regions to provide one coherent profiling. Thede factoamplicon length is the total length of all amplified regions, thus providing much higher resolution compared to current techniques. Computationally, the method solves a convex optimization problem that allows extremely fast reconstruction and requires only moderate memory. We demonstrate the increase in resolution byin silicosimulations and by profiling two mock mixtures and real-world biological samples. Reanalyzing a mock mixture from the Human Microbiome Project achieved about two-fold improvement in resolution when combing two independent regions. Using a custom set of six primer pairs spanning about 1200bp (80%) of the 16S rRNA gene we were able to achieve ~100 fold improvement in resolution compared to a single region, over a mock mixture of common human gut bacterial isolates. Finally, profiling of aDrosophila melanogastermicrobiome using the set of six primer pairs provided a ~100 fold increase in resolution, and thus enabling efficient downstream analysis.ConclusionsSMURF enables identification of near full-length 16S rRNA gene sequences in microbial communities, having resolution superior compared to current techniques. It may be applied to standard sample preparation protocols with very little modifications. SMURF also paves the way to high-resolution profiling of low-biomass and fragmented DNA, e.g., in the case of Formalin-fixed and Paraffin-embedded samples, fossil-derived DNA or DNA exposed to other degrading conditions. The approach is not restricted to combining amplicons of the 16S rRNA gene and may be applied to any set of amplicons, e.g., in Multilocus Sequence Typing (MLST).
Growth barriers of women-owned home-based businesses in Iran: an exploratory study
Authors: Modarresi Meisam , Arasti Zahra , Talebi Kambiz , Farasatkhah Maghsoud 
Published: June 2017

Purpose
The purpose of this paper is to identify the growth barriers of women’s home-based businesses (HBBs) in Iran.

Design/methodology/approach
The qualitative approach was used by 22 in-depth interviews with Iranian female HBBs owners/mangers.

Findings
Business growth barriers of women were categorized in a multi-level framework of individual barriers (micro), business-related barriers (medium) and environmental barriers (macro). The most important micro-level barrier is lack of skills and experience, while the financial barriers identified as the most business-related one and, finally, the problems of having work interactions with men is the most important environmental barrier women-owned HBBs mentioned.

Research limitations/implications
The results of this paper can help policy-makers better understand growth barriers for women-owned HBB and attenuate these barriers by developing purposeful supportive growth policies that are commensurate with the barriers. Also, HBB women owners themselves could better concentrate on removing barriers by deepening their understanding of their business growth barriers.

Originality/value
The paper contributes to the scarce knowledge about women-owned HBBs in Iran, a rapidly growing, developing country, which can provide better insights from a less explored context. Moreover, as there is only a limited understanding of HBB growth, especially in relation to women business owners, the paper results can prove helpful for researchers in the domain of female entrepreneurs.