bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Chondroblastoma‐like” epithelioid fibrous histiocytoma: A previously undescribed and potentially confusing variant
Authors: Martinez Anthony P. , Zou Youran , Billings Steven D. , Folpe Andrew L. 
Published: October 2017

BackgroundEpithelioid benign fibrous histiocytoma has been considered a variant of fibrous histiocytoma, but is now considered a distinct entity, typically showing ALK expression. Most show typical morphological features, including an epidermal collarette and large, bland, epithelioid cells. We have recently encountered 2 examples showing an unusual pattern of pericellular calcification, a previously unreported finding.MethodsAvailable slides were reviewed and clinical follow‐up was obtained.ResultsThese lesions occurred on the chins of a 16‐year‐old and 19‐year‐old female and showed prominent pericellular calcification in addition to otherwise‐typical features of epithelioid fibrous histiocytoma. By immunohistochemistry, both lesions were intensely positive for ALK protein. Clinical follow‐up (available for 1 case) showed the patient to be disease‐free 5 months after excision.ConclusionsTo the best of our knowledge, epithelioid fibrous histiocytomas showing “chondroblastoma‐like” calcification have not been previously reported. The chief significance of this finding seems to be in its potential for confusion with other calcifying tumors of the skin and subcutis. Awareness that epithelioid fibrous histiocytomas may show this unusual morphological finding, careful morphological evaluation and ancillary immunohistochemical studies, including ALK protein, should allow for their confident diagnosis in essentially all instances.
Estimating medial gastrocnemius muscle volume in children with spastic cerebral palsy: a cross‐sectional investigation
Authors: Schless Simon‐Henri , Hanssen Britta , Cenni Francesco , Bar‐On Lynn , Aertbeliën Erwin , Molenaers Guy , Desloovere Kaat 
Published: October 2017

AimThis cross‐sectional investigation evaluates the reliability of estimating medial gastrocnemius anatomical cross‐sectional area (aCSA) in typically developing and spastic cerebral palsy (SCP) cohorts. It verifies whether muscle volume estimations based on aCSA improve when aCSA is multiplied by muscle–tendon unit (MTU) or muscle length, and whether the resulting errors in volume estimations are smaller than changes after intervention.MethodFifteen typically developing children (mean age 8y 2mo [SD 1y 5mo], six males, nine females) and 30 children with SCP (mean age 9y 2mo [SD 2y 5mo], 22 males, eight females, Gross Motor Function Classification System [GMFCS] level I=15, II=15) participated in the investigation. The SCP cohort was divided according to GMFCS level. A three‐dimensional freehand ultrasound technique was used to estimate medial gastrocnemius aCSA, muscle volume, MTU, and muscle length. Estimated muscle volume (aCSA×MTU or muscle length) was compared with the measured muscle volume.ResultsAnatomical cross‐sectional area, muscle volume, and muscle length significantly differed between the typically developing and two SCP cohorts (p≤0.050). aCSA multiplied by either MTU or muscle length improved estimations of medial gastrocnemius volume. Leave‐one‐out cross‐validation revealed an absolute difference with measured muscle volume of 3.77 ml (SD 2.90).InterpretationThis investigation revealed that medial gastrocnemius muscle volume can be reliably estimated in a clinically feasible manner in typically developing children and those with SCP.What this paper adds

Medial gastrocnemius anatomical cross‐sectional area (aCSA) can be reliably estimated in children with spastic cerebral palsy.

The location of the anatomical cross‐section should be taken with respect to muscle and not bone length.

Medial gastrocnemius volume can be reliably estimated by multiplying aCSA and muscle length.

The errors in volume estimations are smaller than reported differences after interventions.
Ventricular dyssynchrony as a marker of latent carditis in children with acute rheumatic fever: A tissue Doppler imaging
Authors: Mahfouz Ragab A. , Alawady Waleed S. , Salem Abdelhakeem 
Published: October 2017

ObjectiveWe aimed to investigate the hypothesis that the presence of left ventricular (LV) dyssynchrony in children with acute rheumatic fever (ARF) children may be a predictor of latent rheumatic carditis.MethodsEighty‐nine children with ARF and 45 healthy control children were included the study. LV dyssynchrony was investigated by color‐coded tissue Doppler imaging.ResultsLV dyssynchrony parameters including Ts‐SD‐12, Ts‐12, Ts‐SD‐6, and Ts‐6 were found to be prolonged in children with ARF than in controls (P < .001). We found that 45.2% in children with ARF without carditis had LV dyssynchrony (Ts‐SD‐12 ≥ 34.4 ms), while 63.4% in children with ARF with carditis had LV dyssynchrony. Follow‐up analysis demonstrated that children with arthritis and without dyssynchrony had no adverse events (recurrent rheumatic activity, development of valvular diseases; heart failure and atrial fibrillation), while those with LV dyssynchrony had events rate of 40.9% (P < .001). Likewise, children with carditis had event rates of 63.4%. Ts‐SD‐12 was found to be correlated with hs‐CRP (r = .63; P < .001). Receiver‐operating characteristic (ROC) curve analysis showed that a Ts‐SD‐12 ≥ 36.5 was the optimal cutoff value in predicting unfavorable outcome in patients with ARF, with a sensitivity of 95% and specificity of 82%.ConclusionsWe found that children with ARF without any evidence of carditis had a significant LV systolic dyssynchrony spite of normal EF. LV dyssynchrony in those children had a significant event rates on follow‐up. These results highlighted the incremental value of LV dyssynchrony as a marker of subclinical carditis in children with ARF.
High mortality and enhanced recovery: modelling the countervailing effects of disturbance on population dynamics
Authors: McMullen Laura E. , De Leenheer Patrick , Tonkin Jonathan D. , Lytle David A. 
Published: October 2017

AbstractDisturbances cause high mortality in populations while simultaneously enhancing population growth by improving habitats. These countervailing effects make it difficult to predict population dynamics following disturbance events. To address this challenge, we derived a novel form of the logistic growth equation that permits time‐varying carrying capacity and growth rate. We combined this equation with concepts drawn from disturbance ecology to create a general model for population dynamics in disturbance‐prone systems. A river flooding example using three insect species (a fast life‐cycle mayfly, a slow life‐cycle dragonfly and an ostracod) found optimal tradeoffs between disturbance frequency vs. magnitude and a close fit to empirical data in 62% of cases. A savanna fire analysis identified fire frequencies of 3–4 years that maximised population size of a perennial grass. The model shows promise for predicting population dynamics after multiple disturbance events and for management of river flows and fire regimes.
High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone
Authors: Basic‐Kinda Sandra , Karlak Ivan , Durakovic Nadira , Lubina Zvonimir I. , Livaja Radman Ivo , Dotlic Snježana , Peric Zinaida , Hude Ida , Aurer Igor 
Published: October 2017

AbstractBackgroundEscalated BEACOPP (eBEACOPP) is an effective but fairly toxic regimen for the treatment of Hodgkin lymphoma (HL). Avascular necrosis (AVN) of femoral head was previously reported to increase in patients treated with eBEACOPP, but so far, no systematic analysis of its frequency has been published.AimsTo analyse the frequency and identify possible risk factors for AVN development in patients treated with eBEACOPP.MethodsWe identified 26 patients treated with eBEACOPP for newly diagnosed high‐risk advanced‐stage HL, 25 of whom were alive at the time of study. All patients were invited to participate in a cross‐sectional study; 17 patients responded and were evaluated by magnetic resonance imaging and orthopaedic examination.ResultsSix patients (35.3%) were diagnosed with AVN after receiving eBEACOPP treatment. AVN was not correlated with age, gender, number of received eBEACOPP cycles, irradiation therapy or cumulative dose of steroids administered. There were significantly more cases of AVN in patients receiving methylprednisolone than prednisone (P = 0.01).ConclusionThe use of methylprednisolone was shown to be a risk factor for the development of AVN in patients treated with eBEACOPP and should not be the corticosteroid of choice in the treatment of patients with HL.
Association between γ marker, human leucocyte antigens and killer immunoglobulin‐like receptors and the natural course of human cytomegalovirus infection: a pilot study performed in a Sicilian population
Authors: Di Bona Danilo , Accardi Giulia , Aiello Anna , Bilancia Massimo , Candore Giuseppina , Colomba Claudia , Caruso Calogero , Duro Giovanni , Gambino Caterina M. , Macchia Luigi , Pandey Janardan P. 
Published: October 2017

SummaryNatural killer (NK) cells provide a major defence against human cytomegalovirus (HCMV) infection through the interaction of their surface receptors, including the activating and inhibitory killer immunoglobulin‐like receptors (KIRs), and human leucocyte antigen (HLA) class I molecules. Also γ marker (GM) allotypes, able to influence the NK antibody‐dependent cell‐mediated cytotoxicity, appear to be involved in the immunological control of virus infections, including HCMV. In some cases, their contribution requires epistatic interaction with other genes of the immune system, such as HLA. In the present report, with the aim of gaining insight into the immune mechanisms controlling HCMV, we have studied the possible associations among humoral and NK responses, and HCMV infections. In a previous study we assessed whether the KIR and HLA repertoire might influence the risk of developing symptomatic (n = 60) or asymptomatic (n = 60) disease after primary HCMV infection in the immunocompetent host. In the present study, the immunocompetent patients with primary symptomatic HCMV infection were genotyped for GM3/17 and GM23 allotypes, along with the 60 participants with a previous asymptomatic infection as controls. Notwithstanding the presence of missing data record, advanced missing data recovery techniques were able to show that individuals carrying the GM23 allotypes, both homozygous and heterozygous, GM17/17, HLA‐C2 and Bw4T KIR‐ligand groups are associated with the risk of developing symptomatic infection. Our findings on the role of both cellular and humoral immunity in the control of HCMV infection should be of value in guiding efforts to reduce HCMV‐associated health complications in the elderly, including immunosenescence, and in transplantation.
VALUE, PRICE, AND EXPLOITATION: THE LOGIC OF THE TRANSFORMATION PROBLEM
Authors: Mohun Simon , Veneziani Roberto 
Published: October 2017

AbstractThis paper tries to clarify the logical structure of the relationship between labor values and prices from an axiomatic perspective. The famous “transformation problem” is interpreted as an impossibility result for a specific interpretation of value theory based on specific assumptions and definitions. A comprehensive review of recent literature is provided, which shows that there are various theoretically relevant and logically consistent alternative interpretations based on different assumptions and definitions.
Scoring model to predict massive post‐partum bleeding in pregnancies with placenta previa: A retrospective cohort study
Authors: Lee Ji Yeon , Ahn Eun Hee , Kang Sukho , Moon Myung Jin , Jung Sang Hee , Chang Sung Woon , Cho Hee Young 
Published: October 2017

AbstractAimWe aimed to identify factors associated with massive post‐partum bleeding in pregnancies with placenta previa and to establish a scoring model to predict post‐partum severe bleeding.MethodsA retrospective cohort study was performed in 506 healthy singleton pregnancies with placenta previa from 2006 to 2016. Cases with intraoperative blood loss (≥2000 mL), packed red blood cells transfusion (≥4), uterine artery embolization, or hysterectomy were defined as massive bleeding. After performing multivariable analysis, using the adjusted odds ratios (aOR), we formulated a scoring model.ResultsSeventy‐three women experienced massive post‐partum bleeding (14.4%). After multivariable analysis, seven variables were associated with massive bleeding: maternal old age (≥35 years; aOR 1.79, 95% confidence interval [CI] 1.00–3.20, P = 0.049), antepartum bleeding (aOR 4.76, 95%CI 2.01–11.02, P < 0.001), non‐cephalic presentation (aOR 3.41, 95%CI 1.40–8.30, P = 0.007), complete placenta previa (aOR 1.93, 95%CI 1.05–3.54, P = 0.034), anterior placenta (aOR 2.74, 95%CI 1.54–4.89, P = 0.001), multiple lacunae (≥4; aOR 2.77, 95%CI 1.54–4.99, P = 0.001), and uteroplacental hypervascularity (aOR 4.51, 95%CI 2.30–8.83, P < 0.001). We formulated a scoring model including maternal old age (<35: 0, ≥35: 1), antepartum bleeding (no: 0, yes: 2), fetal non‐cephalic presentation (no: 0, yes: 2), placenta previa type (incomplete: 0, complete: 1), placenta location (posterior: 0, anterior: 1), uteroplacental hypervascularity (no: 0, yes: 2), and multiple lacunae (no: 0, yes: 1) to predict post‐partum massive bleeding. According to our scoring model, a score of 5/10 had a sensitivity of 81% and a specificity of 77% for predicting massive post‐partum bleeding. The area under the receiver–operator curve was 0.856 (P < 0.001). The negative predictive value was 95.9%.ConclusionOur scoring model might provide useful information for prediction of massive post‐partum bleeding in pregnancies with placenta previa.
Standardized ileal digestibility of amino acids in European soya bean and rapeseed products fed to growing pigs
Authors: Kaewtapee C. , Mosenthin R. , Nenning S. , Wiltafsky M. , Schäffler M. , Eklund M. , Rosenfelder‐Kuon P. 
Published: October 2017

SummaryThis study was conducted to determine the chemical composition and standardized ileal digestibility coefficients (SID) of crude protein (CP) and amino acids (AA) of European soya bean and rapeseed products in pigs. Six soya bean and two rapeseed products were used as the sole dietary source of CP and AA, including raw (FFSB) and roasted full‐fat soya beans (FFSBRoasted), soya bean (SBC) and rapeseed cake (RSC), and rapeseed meal (RSM) from Bavaria (Germany), soya bean meal (SBM) from the Danube region (Austria; SBMAustria), a commercially available standard SBM (SBMStd) and an imported genetically modified organism‐free SBM (SBMGMO‐free). Eight ileal‐ cannulated pigs with an initial body weight of 32 ± 2 kg were allotted to a row‐column design with eight diets and six periods of seven days each. Trypsin inhibitor activity (TIA) ranged from 1.8 in SBMStd to 24.5 mg/g DM in FFSB. The SID of CP and all AA in FFSBRoasted were greater than in FFSB, but lower when compared to SBC and SBMAustria (p < .05). The SID of CP and all AA (except glutamic acid) were not different between SBC and SBMAustria, but the SID of CP and all AA (except methionine) were greater (p < .05) in SBC than in SBMGMO‐free. Furthermore, the SID of CP and most AA showed a quadratic response with decreasing TIA, and there exists a quadratic response in SID of CP and all AA with increasing lysine to CP ratio and neutral detergent insoluble nitrogen (p < .05). In conclusion, variation in chemical composition and SID of CP and AA was observed in different European soya bean and rapeseed products as influenced by differences in processing conditions. European SBC and SBMAustria can be used as alternative to imported SBMGMO‐free and SBMStd in diets for growing pigs.
Monitoring of fusion gene transcripts to predict relapse in pediatric acute myeloid leukemia
Authors: Matsuo Hidemasa , Iijima‐Yamashita Yuka , Yamada Miho , Deguchi Takao , Kiyokawa Nobutaka , Shimada Akira , Tawa Akio , Tomizawa Daisuke , Taga Takashi , Kinoshita Akitoshi , Adachi Souichi , Horibe Keizo 
Published: October 2017

AbstractBackgroundIn acute myeloid leukemia (AML), accurate detection of minimal residual disease (MRD) enables better risk‐stratified therapy. There are few studies, however, on the monitoring of multiple fusion transcripts and evaluation of their accuracy as indicators of MRD at multiple time points.MethodsWe retrospectively examined RNA obtained from 82 pediatric AML patients enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML‐05 study. The expression of six important fusion transcripts (AML1(RUNX1)‐ETO, CBFB‐MYH11, MLL(KMT2A)‐AF9, MLL‐ELL, MLL‐AF6, and FUS‐ERG) was analyzed at five time points 30–40 days apart following diagnosis.ResultsIn patients with AML1‐ETO (n = 36 at time point 5), all six patients with >3,000 copies and four of 30 patients with ≤3,000 copies relapsed. AML1‐ETO transcripts persisted during treatment even in patients without relapse, as well as CBFB‐MYH11 transcripts. In contrast, in patients with MLL‐AF9 (n = 9 at time point 5), two patients were positive for MLL‐AF9 expression (>50 copies) and both relapsed. Only one of seven MLL‐AF9‐negative patients relapsed. In the AML1‐ETO group, MRD‐positive patients (>3,000 copies at time point 5) had significantly lower relapse‐free survival (RFS; P < 0.0001) and overall survival (OS; P = 0.009) than MRD‐negative patients. Similarly, in the MLL‐AF9 group, MRD‐positive patients (>50 copies at time point 5) had significantly lower RFS (P = 0.002) and OS (P = 0.002) than MRD‐negative patients.ConclusionsDetection of MLL‐AF9 transcripts on real‐time quantitative polymerase chain reaction is a promising marker of relapse in pediatric AML. In contrast, the clinical utility of detecting AML1‐ETO and CBFB‐MYH11 expression is limited, although higher AML1‐ETO expression can be a potential predictor of relapse when assessed according to an optimal threshold.
Quality of life after living donor liver transplant for biliary atresia in Japan
Authors: Kikuchi Ryota , Mizuta Koichi , Urahashi Taizen , Sanada Yukihiro , Yamada Naoya , Onuma Erika , Sato Iori , Kamibeppu Kiyoko 
Published: October 2017

AbstractBackgroundHealth‐related quality of life (HRQOL) is an important outcome in solid organ transplantation. This study evaluated and explored the factors of generic and transplant‐specific HRQOL in Japanese pediatric and adolescent patients with biliary atresia (BA) after living donor liver transplant (LDLT).MethodsA cross‐sectional survey using anonymous questionnaires was completed between April and July 2015. Patient medical records were accessed. The Japanese version of Pediatric Quality of Life InventoryTM Generic Core Scales and Transplant Modules (child self‐report and parent proxy‐report) was administered.ResultsParticipants consisted of 75 patients (mean age at survey, 9.6 years) and 74 parents. Japanese patients reported higher generic and transplant‐specific HRQOL (total score) than that reported by US patients with BA after LT (US I; age at survey, 7.2 years) and by US patients after solid organ transplant (US II; age at survey, 11.3 years; LT, 53.8%; effect size, 0.55–0.96). Japanese parents, however, rated their children's generic HRQOL (total score) similar to that rated by the US I and II parents (0.13 and 0.30, respectively) and reported lower transplant‐specific HRQOL (total score) than that reported by US II (0.26). Although the number of types of prescribed drugs was a common factor in HRQOL, most demographic and medical factors (e.g. child's age at survey and consultation frequency) varied with reporter (i.e. patients and parents).ConclusionsThe levels and factors of generic and transplant‐specific HRQOL of Japanese pediatric and adolescent patients with BA after LDLT varied with reporter (i.e. patients or parents).
The Design and Practice of Integrating Evidence: Connecting Performance Management with Program Evaluation
Authors: Kroll Alexander , Moynihan Donald P. 
Published: October 2017

AbstractIn recent decades, governments have invested in the creation of two forms of knowledge production about government performance: program evaluations and performance management. Prior research has noted tensions between these two approaches and the potential for complementarities when they are aligned. This article offers empirical evidence on how program evaluations connect with performance management in the U.S. federal government in 2000 and 2013. In the later time period, there is an interactive effect between the two approaches, which, the authors argue, reflects deliberate efforts by the George W. Bush and Barack Obama administrations to build closer connections between program evaluation and performance management. Drawing on the 2013 data, the authors offer evidence that how evaluations are implemented matters and that evaluations facilitate performance information use by reducing the causal uncertainty that managers face as they try to make sense of what performance data mean.
Stochastic Differential Equation Based on a Multimodal Potential to Model Movement Data in Ecology
Authors: Gloaguen Pierre , Etienne Marie-Pierre , Le Corff Sylvain 
Published: October 2017

SummaryThe paper proposes a new model for individuals’ movement in ecology. The movement process is defined as a solution to a stochastic differential equation whose drift is the gradient of a multimodal potential surface. This offers a new flexible approach among the popular potential-based movement models in ecology. To perform parameter inference, the widely used Euler method is compared with two other pseudolikelihood procedures and with a Monte Carlo expectation–maximization approach based on exact simulation of diffusions. Performances of all methods are assessed with simulated data and with a data set of fishing vessel trajectories. We show that the usual Euler method performs worse than the other procedures for all sampling schemes.
Feature analysis of ultrasound elastography image for quantitative assessment of cutaneous carcinoma
Authors: Morris M. A. , Ring C. M. , Managuli R. , Saboury B. , Mehregan D. , Siegel E. , Dasgeb B. 
Published: October 2017

AbstractBackgroundTo evaluate the feasibility of using quantitative texture features computed from high frequency ultrasound and ultrasound elastography (USE) images in the discrimination of benign from malignant skin lesions.MethodsA commercial ultrasound system with a 14 MHz transducer was used to visualize skin lesions requiring biopsy on clinical evaluation. Patients were enrolled over a 6‐month period and imaged prospectively by operators blind to the histopathologic diagnosis. Anatomic ultrasound and USE imaging of the skin lesions was performed using a 2‐4 mm gel standoff pad before biopsy and histopathologic evaluation. The ElastoAnalysis software developed for the texture analysis of USE images was provided by Hitachi. The software computes thirteen texture features within a region of interest (ROI), which have demonstrated promise in diagnostic characterization of liver fibrosis staging and in quantitative elastography of breast cancer. This approach has not yet been studied in the quantitative assessment of skin cancer. Results were retrospectively compared to the histopathologic diagnosis and a diagnostic criteria with the goal of maximizing sensitivity was evaluated for each textural feature.ResultsOf the 37 lesions included, among 30 patients who participated, 12 lesions were malignant and 25 were benign. Eleven out of thirteen textural metrics computed by the software were useful in differentiating benign from malignant lesions with 100% sensitivity and specificities ranging from 28% to 85%.ConclusionsThis feasibility study demonstrated that feature analysis of USE may be useful in quantitatively differentiating cancerous from benign primary solitary skin lesions prior to biopsy.