bluuebunny/crossref_metadata_2025_split huggingface dataset:
Totally implantable hearing system: Five‐year hearing results
Authors: Shohet Jack A. , Kraus Eric M. , Catalano Peter J. , Toh Elizabeth 
Published: April 2017

Objectives/Hypothesis1) To provide long‐term hearing outcome measures of a totally implantable hearing system (implant) and compare to the baseline unaided (BLU) and baseline aided (BLA) conditions, and 2) discuss relevant safety measures.Study DesignProspective, nonrandomized, multicenter, single‐subject‐as‐own‐control design.MethodsFifty‐one subjects with mild to severe sensorineural hearing loss were implanted between 2008 and 2009 and enrolled in this postmarket approval study in the setting of private and hospital‐based practices. Forty‐nine of these subjects completed the 5‐year study, which included annual follow‐ups. Primary effectiveness endpoints were speech reception threshold (SRT) and word recognition scores at 50 dB (WRS50s). Secondary effectiveness endpoints were WRSs and the Abbreviated Profile of Hearing Aid Benefit (APHAB) scores. Adverse Device Effects (ADEs) and Serious Adverse Device Effects (SADEs) reported during the study period and a comparison of bone conduction scores are submitted as safety measures.ResultsCompared to the BLA condition, 1) SRT scores were improved at every annual follow‐up; 2) WRS50s were better in 49%, and the same in 41% at the 5‐year follow‐up; 3) WRSs were improved by 17% at the 5‐year follow‐up; and 4) APHAB scores were improved in most subscales at every annual follow‐up. There were three SADEs in three subjects and 15 ADEs in 11 subjects. Bone conduction scores increased by 3.7 dB at the 5‐year follow‐up. Average battery life was 4.9 years.ConclusionsThe implant compared favorably to the subjects' hearing aid throughout the 5‐year period in all of the areas measured and was found to be safe.Level of Evidence2b. Laryngoscope, 128:210–216, 2018
Construction and 13C hyperpolarization efficiency of a 180 GHz dissolution dynamic nuclear polarization system
Authors: Kiswandhi Andhika , Niedbalski Peter , Parish Christopher , Ferguson Sarah , Taylor David , McDonald George , Lumata Lloyd 
Published: April 2017

Dynamic nuclear polarization (DNP) via the dissolution method has become one of the rapidly emerging techniques to alleviate the low signal sensitivity in nuclear magnetic resonance (NMR) spectroscopy and imaging. In this paper, we report on the development and 13C hyperpolarization efficiency of a homebuilt DNP system operating at 6.423 T and 1.4 K. The DNP hyperpolarizer system was assembled on a wide‐bore superconducting magnet, equipped with a standard continuous‐flow cryostat, and a 180 GHz microwave source with 120 mW power output and wide 4 GHz frequency tuning range. At 6.423 T and 1.4 K, solid‐state 13C polarization P levels of 64% and 31% were achieved for 3 M [1‐13C] sodium acetate samples in 1 : 1 v/v glycerol:water glassing matrix doped with 15 mM trityl OX063 and 40 mM 4‐oxo‐TEMPO, respectively. Upon dissolution, which takes about 15 s to complete, liquid‐state 13C NMR signal enhancements as high as 240 000‐fold (P=21%) were recorded in a nearby high resolution 13C NMR spectrometer at 1 T and 297 K. Considering the relatively lower cost of our homebuilt DNP system and the relative simplicity of its design, the dissolution DNP setup reported here could be feasibly adapted for in vitro or in vivo hyperpolarized 13C NMR or magnetic resonance imaging at least in the pre‐clinical setting. Copyright © 2017 John Wiley & Sons, Ltd.
Female striated urogenital sphincter contraction measured by shear wave elastography during pelvic floor muscle activation: Proof of concept and validation
Authors: Aljuraifani Rafeef , Stafford Ryan E. , Hug François , Hodges Paul W. 
Published: April 2017

AimsInvestigation of the function of the striated urogenital sphincter (SUS) is challenging because it is difficult to access and requires invasive measures. Ultrasound shear wave elastography (SWE) is a non‐invasive real‐time technique used to estimate tissue stiffness. As muscle stiffness can be used as an estimate of muscle force, SWE provides an opportunity to study contraction of the peri‐urethral musculature. Validation of SWE to study SUS during functional tasks, such as pelvic floor muscle contractions, is required prior to application in clinical populations.MethodsTen healthy females (34[5] years) participated. Stiffness in a region expected to contain the SUS was quantified using SWE at rest and during a pelvic floor muscle contractions performed at 10%, 25%, and 50% of maximal voluntary contraction (MVC). Two repetitions were performed for 10 s.ResultsDuring contraction, stiffness increased in the region of the SUS in all participants and at all contraction intensities. Multiple regions of increased stiffness were detected, with 95.8% of regions situated ventral to the mid‐urethra within the anatomical area of the SUS. The increase in stiffness was greater for 50% MVC than both 10% and 25% MVC contraction intensities (P < 0.01).ConclusionsStiffness increased within the anatomical region of the SUS during voluntary pelvic floor muscle contractions with predictable response to changes in contraction intensity. These observations support the potential for ultrasound SWE to study SUS function non‐invasively.
Severe depression and anxiety in women with overactive bladder
Authors: Melotti Iane Glauce Ribeiro , Juliato Cássia Raquel Teatin , Tanaka Mariana , Riccetto Cassio Luiz Zanettini 
Published: April 2017

AimDepression and anxiety are prevalent psychiatric conditions and are associated with overactive bladder. The objective of this study was to determine prevalence and severity of anxiety and depression associated with overactive bladder (OAB) in women.Methods274 women with clinical diagnosis of OAB were recruited from 2012 to 2015. They were submitted to the International Consultation on Incontinence Questionnaire‐Overactive Bladder (ICIQ‐OAB), the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI).ResultsSevere or moderate depression was present in 59.8% of women and severe or moderate anxiety was identified in 62.4%. Higher scores of depression and anxiety were associated with higher scores of ICIQ‐OAB (P = 0.0031 and 0.0049). Women with severe depression had higher nocturia score than those with mild depression (P = 0.0046). Also, women with severe depression had higher urgency incontinence score than those with minimal depression (P = 0.0261). Patients with severe anxiety had higher nocturia score than those with minimal anxiety (P = 0.0118) and women with moderate anxiety had higher urgency incontinence score than with minimal anxiety (P = 0.0300).ConclusionsModerate or severe depression and anxiety are prevalent in women with OAB. There is a correlation between intensity of OAB symptoms with depression and anxiety. Anxiety and depression levels are mainly related with urgency incontinence and nocturia.
FDM solutions to linear dynamics of porous media: Efficiency, stability, and parallel solution strategy
Authors: Zhang Yunpeng , Pedroso Dorival M. , Li Ling , Ehlers Wolfgang 
Published: April 2017

SummaryThis paper presents a strategy to improve the efficiency of simulations involving porous materials with linear behaviour and full saturation. The method is named parallel‐lines finite difference and uses a method to decouple a discretised version of the governing equations allowing parallel computations. As a result, the complexity and the bandwidth of the global matrix are significantly reduced and hence the efficiency is improved. The other advantage of the scheme is the fulfilment of the inf‐sup stability condition. The scheme is developed to solve porous media formulations derived from the theory of porous media. Both the u‐p and u‐v‐p formulations are considered (u: displacement of solid, p: pressure of liquid, and v: velocity of liquid). Several simulations are performed to demonstrate the capabilities of the method.
Synthesis of hyperbranched polymers from vegetable oil based monomers via ozonolysis pathway
Authors: Sun Jingjiang , Aly Kamal I. , Kuckling Dirk 
Published: April 2017

ABSTRACTIn this work, a variety of hyperbranched polymers (HBPs), such as hyperbranched polycarbonates, polyesters, polyurethanes and polyacetals, was successfully synthesized from castor oil and soybean oil based monomers via a A2 + B3 polycondensation. First, B3 monomer triols (TriOL), trialdehydes (TriAD), and tricarboxylic acids (TriAC) were obtained by ozonolysis of castor oil and soybean oil with following reductive or oxidative treatment. Their structures were characterized by 1H NMR and ATR‐FTIR spectroscopy as well as electrospray ionization‐Time of Flight‐mass spectrometry. These trifunctional B3 monomers were applied in the preparation of HBPs. The resulting HBPs had number averaged molar mass (Mn) up to 9400 g/mol and weight averaged molar mass (Mw) up to 40,000 g/mol. Through adjusting the initial molar ratio of A2 to B3 monomers, hydroxyl terminated (from TriOL monomers) or carboxylic acid (from TriAC monomers) terminated HBPs could be obtained. All the HBPs were characterized by 1H NMR, size exclusion chromatography, and DSC. These HBPs are potential candidates for the synthesis of cross‐linked polymeric materials or in biomedical applications. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2104–2114
Identification of a conserved 8 aa insert in the PIP5K protein in the Saccharomycetaceae family of fungi and the molecular dynamics simulations and structural analysis to investigate its potential functional role
Authors: Khadka Bijendra , Gupta Radhey S. 
Published: April 2017

ABSTRACTHomologs of the phosphatidylinositol‐4‐phosphate‐5‐kinase (PIP5K), which controls a multitude of essential cellular functions, contain a 8 aa insert in a conserved region that is specific for the Saccharomycetaceae family of fungi. Using structures of human PIP4K proteins as templates, structural models were generated of the Saccharomyces cerevisiae and human PIP5K proteins. In the modeled S. cerevisiae PIP5K, the 8 aa insert forms a surface exposed loop, present on the same face of the protein as the activation loop of the kinase domain. Electrostatic potential analysis indicates that the residues from 8 aa conserved loop form a highly positively charged surface patch, which through electrostatic interaction with the anionic portions of phospholipid head groups, is expected to play a role in the membrane interaction of the yeast PIP5K. To unravel this prediction, molecular dynamics (MD) simulations were carried out to examine the binding interaction of PIP5K, either containing or lacking the conserved signature insert, with two different membrane lipid bilayers. The results from MD studies provide insights concerning the mechanistic of interaction of PIP5K with lipid bilayer, and support the contention that the identified 8 aa conserved insert in fungal PIP5K plays an important role in the binding of this protein with membrane surface. Proteins 2017; 85:1454–1467. © 2017 Wiley Periodicals, Inc.
The Brownian plane with minimal neck baby universe
Authors: Wen Yuting 
Published: April 2017

AbstractFor each , let be a uniform rooted quadrangulation, endowed with an appropriate measure, of size n conditioned to have r(n) vertices in its root block. We prove that for a suitable function r(n), after rescaling graph distance by converges to a random pointed non‐compact metric measure space , in the local Gromov‐Hausdorff‐Prokhorov topology. The space is built by identifying a uniform point of the Brownian map with the distinguished point of the Brownian plane. © 2017 Wiley Periodicals, Inc. Random Struct. Alg., 51, 729–752, 2017
Alliance or Acquisition? A Mechanisms‐Based, Policy‐Capturing Analysis
Authors: Mellewigt Thomas , Thomas Adeline , Weller Ingo , Zajac Edward J. 
Published: April 2017

Research summary: While alliance researchers view prior partner‐specific alliance experience as influencing firms' subsequent alliance or acquisition decisions, empirical evidence on the alliance versus acquisition decision is surprisingly mixed. We offer a reconciliation by proposing and testing an analytical framework that recognizes prior partner‐specific experiences as heterogeneous along three fundamental dimensions: partner‐specific trust, routines, and value certainty. This allows us to use a policy‐capturing methodology to rigorously operationalize and test our mechanism‐level predictions. We find that all three mechanisms can increase the likelihood of a subsequent alliance or acquisition, and in terms of the comparative choice between alliances versus acquisitions, partner‐specific trust pulls towards alliances, and value certainty pulls towards acquisitions. We conclude with a discussion of the theoretical and empirical implications of our approach and method.Managerial summary: This study focuses on an important corporate decision: When a firm has had an alliance with another firm, how would that experience affect the likelihood of a future alliance or acquisition with that same firm? We first suggest that it will depend on three factors: the level of trust that existed in that prior alliance, the extent to which specific work routines were developed, and the degree to which the firm was able to confidently assess the value of the partner firm's resources. We then find that trust is a particularly strong predictor of future alliances, while confidence regarding value more strongly predicts future acquisitions. In this way, we demonstrate more precisely how past corporate choices can affect (consciously or unconsciously) future ones. © 2017 The Authors. Strategic Management Journal Published by John Wiley & Sons Ltd.
Brief Report: Robo1 Regulates the Migration of Human Subventricular Zone Neural Progenitor Cells During Development
Authors: Guerrero-Cazares Hugo , Lavell Emily , Chen Linda , Schiapparelli Paula , Lara-Velazquez Montserrat , Capilla-Gonzalez Vivian , Clements Anna Christina , Drummond Gabrielle , Noiman Liron , Thaler Katrina , Burke Anne , Quiñones-Hinojosa Alfredo 
Published: April 2017

Abstract
Human neural progenitor cell (NPC) migration within the subventricular zone (SVZ) of the lateral ganglionic eminence is an active process throughout early brain development. The migration of human NPCs from the SVZ to the olfactory bulb during fetal stages resembles what occurs in adult rodents. As the human brain develops during infancy, this migratory stream is drastically reduced in cell number and becomes barely evident in adults. The mechanisms regulating human NPC migration are unknown. The Slit–Robo signaling pathway has been defined as a chemorepulsive cue involved in axon guidance and neuroblast migration in rodents. Slit and Robo proteins expressed in the rodent brain help guide neuroblast migration from the SVZ through the rostral migratory stream to the olfactory bulb. Here, we present the first study on the role that Slit and Robo proteins play in human-derived fetal neural progenitor cell migration (hfNPC). We describe that Robo1 and Robo2 isoforms are expressed in the human fetal SVZ. Furthermore, we demonstrate that Slit2 is able to induce a chemorepellent effect on the migration of hfNPCs derived from the human fetal SVZ. In addition, when Robo1 expression is inhibited, hfNPCs are unable to migrate to the olfactory bulb of mice when injected in the anterior SVZ. Our findings indicate that the migration of human NPCs from the SVZ is partially regulated by the Slit–Robo axis. This pathway could be regulated to direct the migration of NPCs in human endogenous neural cell therapy.
Parental monitoring, adolescent dishonesty and underage drinking: A nationally representative study
Authors: Lushin Viktor , Jaccard James , Kaploun Victor 
Published: April 2017

ABSTRACTLittle research has connected underage drinking with adolescent information management strategies. The present study uses longitudinal analyses to theoretically link adolescent lying with parental “monitoring knowledge,” and, in turn, with prospective adolescent drinking, in a large nationally representative sample of U.S. seventh‐ and eighth‐graders (N = 4020). Structural equation modeling evaluated and supported, two key hypotheses: (1) dishonesty promotes future alcohol use by decreasing parental monitoring knowledge, and (2) dishonesty directly predicts alcohol consumption independent of its effects on parental monitoring. Maternal warmth and adolescent satisfaction with maternal relationships, but not parental control, were associated with lessened lying, and predicted parental monitoring and underage drinking. Our data implicate the role of adolescent agency for parental monitoring and highlight advantages of cohesive as opposed to over‐restrictive parenting.
WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway
Authors: Sun Yang , Cao Lanqin , Sheng Xunan , Chen Jieying , Zhou Yu , Yang Chao , Deng Tanggang , Ma Hongchang , Feng Peifu , Liu Jing , Tan Weihong , Ye Mao 
Published: April 2017

AbstractWD repeat protein 79 (WDR79) is a member of the WD-repeat protein family and functions as a scaffold protein during telomerase assembly, Cajal body formation and DNA double strand break repair. We have previously shown that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung cancer (NSCLC) and it accelerates cell proliferation in NSCLC. However, the detailed mechanism underlying the role of WDR79 in the proliferation of NSCLC cells remains unclear. Here, we report the discovery of a molecular interaction between WDR79 and USP7 and show its functional significance in linking the Mdm2-p53 pathway to the proliferation of NSCLC cells. We found that WDR79 colocalized and interacted with USP7 in the nucleus of NSCLC cells. This event, in turn, reduced the ubiquitination of Mdm2 and p53, thereby increasing the stability and extending the half-life of the two proteins. We further found that the functional effects of WDR79 depended upon USP7, because the knockdown of USP7 resulted in their attenuation. Finally, we demonstrated that WDR79 promoted the proliferation of NSCLC cells via USP7. Taken together, our findings reveal a novel molecular function of WDR79 and may lead to broadly applicable and innovative therapeutic avenues for NSCLC.
Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation
Authors: Qin Xiang , Park Byung Ouk , Liu Jiaying , Chen Bing , Choesmel-Cadamuro Valerie , Belguise Karine , Heo Won Do , Wang Xiaobo 
Published: April 2017

AbstractPulsatile actomyosin contractility, important in tissue morphogenesis, has been studied mainly in apical but less in basal domains. Basal myosin oscillation underlying egg chamber elongation is regulated by both cell–matrix and cell–cell adhesions. However, the mechanism by which these two adhesions govern basal myosin oscillation and tissue elongation is unknown. Here we demonstrate that cell–matrix adhesion positively regulates basal junctional Rho1 activity and medio-basal ROCK and myosin activities, thus strongly controlling tissue elongation. Differently, cell–cell adhesion governs basal myosin oscillation through controlling medio-basal distributions of both ROCK and myosin signals, which are related to the spatial limitations of cell–matrix adhesion and stress fibres. Contrary to cell–matrix adhesion, cell–cell adhesion weakly affects tissue elongation. In vivo optogenetic protein inhibition spatiotemporally confirms the different effects of these two adhesions on basal myosin oscillation. This study highlights the activity and distribution controls of basal myosin contractility mediated by cell–matrix and cell–cell adhesions, respectively, during tissue morphogenesis.
Pathways for balancing CO2 emissions and sinks
Authors: Walsh Brian , Ciais Philippe , Janssens Ivan A. , Peñuelas Josep , Riahi Keywan , Rydzak Felicjan , van Vuuren Detlef P. , Obersteiner Michael 
Published: April 2017

AbstractIn December 2015 in Paris, leaders committed to achieve global, net decarbonization of human activities before 2100. This achievement would halt and even reverse anthropogenic climate change through the net removal of carbon from the atmosphere. However, the Paris documents contain few specific prescriptions for emissions mitigation, leaving various countries to pursue their own agendas. In this analysis, we project energy and land-use emissions mitigation pathways through 2100, subject to best-available parameterization of carbon-climate feedbacks and interdependencies. We find that, barring unforeseen and transformative technological advancement, anthropogenic emissions need to peak within the next 10 years, to maintain realistic pathways to meeting the COP21 emissions and warming targets. Fossil fuel consumption will probably need to be reduced below a quarter of primary energy supply by 2100 and the allowable consumption rate drops even further if negative emissions technologies remain technologically or economically unfeasible at the global scale.
Rapid population decline in migratory shorebirds relying on Yellow Sea tidal mudflats as stopover sites
Authors: Studds Colin E. , Kendall Bruce E. , Murray Nicholas J. , Wilson Howard B. , Rogers Danny I. , Clemens Robert S. , Gosbell Ken , Hassell Chris J. , Jessop Rosalind , Melville David S. , Milton David A. , Minton Clive D. T. , Possingham Hugh P. , Riegen Adrian C. , Straw Phil , Woehler Eric J. , Fuller Richard A. 
Published: April 2017

AbstractMigratory animals are threatened by human-induced global change. However, little is known about how stopover habitat, essential for refuelling during migration, affects the population dynamics of migratory species. Using 20 years of continent-wide citizen science data, we assess population trends of ten shorebird taxa that refuel on Yellow Sea tidal mudflats, a threatened ecosystem that has shrunk by >65% in recent decades. Seven of the taxa declined at rates of up to 8% per year. Taxa with the greatest reliance on the Yellow Sea as a stopover site showed the greatest declines, whereas those that stop primarily in other regions had slowly declining or stable populations. Decline rate was unaffected by shared evolutionary history among taxa and was not predicted by migration distance, breeding range size, non-breeding location, generation time or body size. These results suggest that changes in stopover habitat can severely limit migratory populations.
Organic light emitting board for dynamic interactive display
Authors: Kim Eui Hyuk , Cho Sung Hwan , Lee Ju Han , Jeong Beomjin , Kim Richard Hahnkee , Yu Seunggun , Lee Tae-Woo , Shim Wooyoung , Park Cheolmin 
Published: April 2017

AbstractInteractive displays involve the interfacing of a stimuli-responsive sensor with a visual human-readable response. Here, we describe a polymeric electroluminescence-based stimuli-responsive display method that simultaneously detects external stimuli and visualizes the stimulant object. This organic light-emitting board is capable of both sensing and direct visualization of a variety of conductive information. Simultaneous sensing and visualization of the conductive substance is achieved when the conductive object is coupled with the light emissive material layer on application of alternating current. A variety of conductive materials can be detected regardless of their work functions, and thus information written by a conductive pen is clearly visualized, as is a human fingerprint with natural conductivity. Furthermore, we demonstrate that integration of the organic light-emitting board with a fluidic channel readily allows for dynamic monitoring of metallic liquid flow through the channel, which may be suitable for biological detection and imaging applications.