bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes After Decompression of the Right Ventricle in Infants With Pulmonary Atresia With Intact Ventricular Septum Are Associated With Degree of Tricuspid Regurgitation
Authors: Petit Christopher J. , Glatz Andrew C. , Qureshi Athar M. , Sachdeva Ritu , Maskatia Shiraz A. , Justino Henri , Goldberg David J. , Mozumdar Namrita , Whiteside Wendy , Rogers Lindsay S. , Nicholson George T. , McCracken Courtney , Kelleman Mike , Goldstein Bryan H. 
Published: May 2017

Background—
Outcomes after right ventricle (RV) decompression in infants with pulmonary atresia with intact ventricular septum vary widely. Descriptions of outcomes are limited to small single-center studies.

Methods and Results—

Neonates undergoing RV decompression for pulmonary atresia with intact ventricular septum were included from 4 pediatric centers. Primary end point was reintervention post-RV decompression; secondary end points included circulation type at latest follow-up. Ninety-nine patients (71 with pulmonary atresia with intact ventricular septum and 28 with virtual atresia) underwent RV decompression at median 3 (25th–75th, 2–5) days of age. Seventy-one patients (72%) underwent at least 1 reintervention after decompression. Median duration of follow-up was 3 years (range, 1–10). Freedom from reintervention was 51% at 1 month and 23% at 3 years. In multivariable analysis, reintervention was associated with virtual atresia (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.28–091;
P
=0.027), smaller RV length (HR, 0.94; 95% CI, 0.89–0.99;
P
=0.027), and ≤mild tricuspid regurgitation (TR; HR, 3.58; 95% CI, 2.04–6.30;
P
<0.001). Patients undergoing surgical shunt or ductal stent were less likely to have virtual atresia (HR, 0.36; 95% CI, 0.15–0.85;
P
=0.02) and more likely to have higher RV end-diastolic pressure (HR, 1.07; 95% CI, 1.00–1.15;
P
=0.057) and ≤mild TR (HR, 3.50; 95% CI, 1.75–7.0;
P
<0.001). Number of reinterventions was associated with ≤mild TR (rate ratio, 1.87; 95% CI, 1.23–2.87;
P
=0.0037). Multivariable analysis indicated that <2-ventricle circulation status was associated with ≤mild TR (odds ratio, 18.6; 95% CI, 5.3–65.2;
P
<0.001) and lower RV area (odds ratio, 0.81; 95% CI, 0.72–0.91;
P
<0.001).

Conclusions—
Patients with pulmonary atresia with intact ventricular septum deemed suitable for RV decompression have a high reintervention burden although most achieve 2-ventricle circulation. TR ≤mild at baseline is strongly associated with reintervention and <2-ventricle circulation at medium-term follow-up. Degree of baseline TR may be an important marker of long-term outcomes in this population.
Legacy Effect of Coronary Perforation Complicating Percutaneous Coronary Intervention for Chronic Total Occlusive Disease
Authors: Kinnaird Tim , Anderson Richard , Ossei-Gerning Nicholas , Cockburn James , Sirker Alex , Ludman Peter , deBelder Mark , Walsh Simon , Smith Elliot , Hanratty Colm , Spratt James , Strange Julian , Hildick-Smith David , Mamas Mamas A. 
Published: May 2017

Background—
Coronary perforation (CP) during chronic total occlusion percutaneous coronary intervention for stable angina (CTO-PCI) is a rare but serious event. The evidence base is limited, and the long-term effects are unclear. Using a national PCI database, the incidence, predictors, and outcomes of CP during CTO-PCI were defined.

Methods and Results—

Data analyzed from the British Cardiovascular Intervention Society data set on all CTO-PCI procedures performed in England and Wales between 2006 and 2013. Multivariate logistic regressions and propensity scores were used to identify predictors of CP and its association with outcomes. A total of 376 CP were recorded from 26 807 CTO-PCI interventions (incidence of 1.40%) with an increase in frequency during the study period (
P
=0.012). Patient-related factors associated with an increased risk of CP were age and female sex. Procedural factors indicative of complex CTO intervention strongly related to an increased risk of CP with a close relationship between the number of complex strategies used and CP evident (
P
=0.008 for trend). Tamponade occurred in 16.6% and emergency surgery in 3.4% of cases. Adverse outcomes were frequent in those patients with perforation including bleeding, transfusion, myocardial infarction, and death. A legacy effect of perforation on mortality was evident, with an odds ratio for 12-month mortality of 1.60 for perforation survivors compared with matched nonperforation survivors without a CP (
P
<0.0001).

Conclusions—
Many of the factors associated with an increased risk of CP were related to CTO complexity. Perforation was associated with adverse outcomes, with a legacy effect on later mortality after CP also observed.
The involvement of people with Parkinson’s in designing a study of the lived experience of anxiety
Authors: Lovegrove Christopher J , Bannigan Katrina , Cheeseman Debbie , Latour Jos M 
Published: May 2017

Introduction Anxiety is a common non-motor symptom of Parkinson’s and is an important consideration for occupational therapists working with this population. Little is known about how people with Parkinson’s experience anxiety. A pragmatic inquiry framework and inductive approach were used to perform a patient and public consultation round to inform future occupational therapy research exploring anxiety in people with Parkinson’s. Method Seven telephone and two Skype interviews were conducted with people with Parkinson’s, who were accessed and recruited through the charity Parkinson’s UK. They were selected on the basis of their previous experience and training to participate in a consultation exercise. Thematic analysis was used to develop codes using an inductive approach. Findings Three key themes emerged: experiences of anxiety in Parkinson’s; coping with anxiety in Parkinson’s; and considerations for future research. These include timing with regards to medication ‘wearing-off’ phenomena, easy access to medications, and providing a safe, sensitive research environment. Occupational therapists need to take these findings into account when designing intervention studies. Conclusion This patient and public involvement consultation round proved valuable and the participants’ contributions will directly improve the design of future occupational therapy research exploring the lived experience of anxiety for people with Parkinson’s.
Structural Behavior of the Endothelial Glycocalyx Is Associated With Pathophysiologic Status in Septic Mice: An Integrated Approach to Analyzing the Behavior and Function of the Glycocalyx Using Both Electron and Fluorescence Intravital Microscopy
Authors: Kataoka Hanae , Ushiyama Akira , Akimoto Yoshihiro , Matsubara Sachie , Kawakami Hayato , Iijima Takehiko 
Published: May 2017

BACKGROUND:
The endothelial surface layer (ESL) regulates vascular permeability to maintain fluid homeostasis. The glycocalyx (GCX), which has a complex and fragile ultrastructure, is an important component of the ESL. Abnormalities of the GCX have been hypothesized to trigger pathological hyperpermeability. Here, we report an integrated in vivo analysis of the morphological and functional properties of the GCX in a vital organ.

METHODS:
We examined the behavior of the ESL and GCX, using both electron microscopy (EM) and intravital microscopy (IVM). We also compared morphological changes in the ESL of mouse skin in a glycosidase-treated and control group. Combined approaches were also used to examine both morphology and function in a lipopolysaccharide-induced septic model and the pathophysiological features of leukocyte–endothelial interactions and in vivo vascular permeability.

RESULTS:
Using IVM, we identified an illuminated part of the ESL as the GCX and confirmed our observation using morphological and biochemical means. In septic mice, we found that the GCX was thinner than in nonseptic controls in both an EM image analysis (0.98 ± 2.08 nm vs 70.68 ± 36.36 nm, P< .001) and an IVM image analysis (0.36 ± 0.15 μm vs 1.07 ± 0.39 μm, P< .001). Under septic conditions, syndecan-1, a representative core protein of the GCX, was released into the blood serum at a higher rate in septic animals (7.33 ± 3.46 ng/mL) when compared with controls (below the limit of detection, P< .001). Significant increases in leukocyte–endothelial interactions, defined as the numbers of rolling or firm-sticking leukocytes, and molecular hyperpermeability to the interstitium were also observed after GCX shedding in vivo.

CONCLUSIONS:
Using IVM, we visualized an illuminated part of the ESL layer that was subsequently confirmed as the GCX using EM. Severe sepsis induced morphological degradation of the GCX, accompanied by shedding of the syndecan-1 core protein and an increase in leukocyte–endothelial interactions affecting the vascular permeability. Our in vivo model describes a new approach to deciphering the relationship between structural and functional behaviors of the GCX.
Tablet e-Logbooks: Four Thousand Clinical Cases and Complications e-Logged by 14 Nondoctor Anesthesia Providers in Nepal
Authors: Shah Shristi , Ross Oliver , Pickering Stephen , Knoble Stephen , Rai Indra 
Published: May 2017

BACKGROUND:
To meet the need for essential surgery across rural Nepal, anesthesia at district level is delivered by nondoctor anesthetists. They require support to maintain confidence and competence, and upgraded professional registration to secure their status. To meet these needs, a distance-blended learning course was pioneered and delivered. A core course requirement was to log all clinical cases; these were logged on a new e-logbook.

METHODS:
Fourteen nondoctor anesthesia providers working in 12 different districts across Nepal were enrolled in the 1-year course. The course is based on self-completion on a tablet loaded with new learning modules, a resource library, and a case logbook. Continuous educational mentoring was provided by anesthesiologists by phone and email. The logbook included preanesthesia assessment and interventions, American Society of Anesthesiologists (ASA) grading, types of cases and anesthesia given, monitors used, complications, outcomes and free text remarks. Cases were uploaded monthly to a database, and mentors reviewed all logbook entries.

RESULTS:
The 14 nondoctor anesthesia providers were widely distributed across the country in district, zonal, community, and mission hospitals, and had different levels of clinical experience and caseloads. Logbooks and uploads were regularly completed without difficulty; 1% cases were entered incompletely with no case details provided. A total of 4143 cases were recorded. Annual caseload per nondoctor anesthesia provider ranged from 50 to 788, the majority of which were under spinal anesthesia; 34% of the total cases were cesarean deliveries, of which 99% received spinal anesthesia. Fifty gastrointestinal laparotomies (1% total) were recorded. Ninety-one percent of cases were ASA I, 0.8% ASA III/IV. Pulse oximetry was used in 98% of cases. Complications were recorded in 6% of cases; the most common were circulation problems (69%) including hypotension and occasional bradycardia after spinal anesthesia. Airway complications were usually under ketamine anesthesia requiring basic airway maneuvers; 4 difficult intubations were recorded under general anesthesia. Anesthesia outcomes were good with overall mortality of 0.1% (total 4 cases). Causes of death included severe preeclampsia, sepsis postlaparotomy, and patients with multiorgan failure for minor procedure.

CONCLUSIONS:
The tablet-based electronic anesthesia logbook was successfully used to record cases, complications, and outcomes across rural Nepal. The nondoctor anesthesia providers had trust and confidence in recording outcomes. It remains to be tested whether an e-logbook would be routinely completed outside of a specific training course. Such a logbook could be incorporated into all continuous professional development programs for rural nondoctor anesthetists.
Appropriateness of action learning in the physical and virtual spaces: a discussion
Authors: Willis Sam , Prass Nicolas , Karstadt Lyn 
Published: May 2017

Paramedics are autonomous health professionals who must graduate into the workforce with complex problem-solving skills, an ability to exercise critical thinking, and clinical reasoning skills to challenging situations, if they are to practise safely. Face-to-face action learning (AL) has long been acknowledged for contributing to the development of such skills, by providing a platform for structured thinking, group working, and a tool for developing participant's ability to ask insightful questions ( Pedler et al, 2005 ) and more recently, action learning in the virtual space is becoming increasingly popular. Virtual action learning has emerged for reasons including globalisation, where the emergence of multi-national and dispersed students has become commonplace ( Dickenson et al, 2010 ) and advances in technology that have allowed more collaborative communication.This discussion paper provides an introduction and background to action learning (AL), virtual action learning (VAL) and explores the appropriateness of these paradigms as a tool for embedding reflective practice and problem-solving skills among undergraduate student paramedics.
Statins: All you need to know
Authors: Rees Sharon 
Published: May 2017

Despite quality and outcomes framework (QOF) targets and impressive research credentials, statins remain underused. Even in those on the medication, statins have failed to reach their full potential in preventing cardiovascular disease (CVD). The reasons for both appear to be multifactorial and probably include public perception, clinician reluctance to switch or up-titrate, as well as concordance issues. This article aims to explain the reasons why statins are important in the adult population, and will provide the prescribing information to enable confident and informed choices to be made by patients and clinicians. The focus is on lipid-lowering drug actions in older adults, rather than on the multitude of potential therapeutic actions of statins, such as treatment of multiple sclerosis and cancer.
Supporting smokers to quit in general practice
Authors: Croghan Emma 
Published: May 2017

Practice nurses can play an invaluable role in helping patients to stop smoking. Emma Croghan outlines smoking risks and different ways people can be helped to quit Smoking tobacco is the single biggest preventable cause of mortality in England and Wales and is the cause of much ill-health with over 1.5 million people in England suffering from a smoking-related disease. This article provides an overview of smoking cessation training needs for practice nurses, information on carbon monoxide and advice on the different methods of cessation and relevant medication.
Driving, not Losing, the Plot: Narrative Patterns in Implicit and Explicit Fictional Representations of Dementia
Authors: Völk Malte 
Published: May 2017

Abstract
This essay examines representations of dementia in literary works. It draws a distinction between those representations of dementia symptoms that can be understood as implicit and those that can be understood as explicit. Whereas implicit representations do not treat dementia as a distinct, clearly identified disorder, they nonetheless display a certain similarity to the explicitly medicalized discussion of dementia symptoms. This similarity lies in the fact that dementia symptoms are used to drive forward the narrative action. The essay traces this pattern by analysing different literary works with this feature in common and discusses the significance of this narrative’s dynamic potential for the plasticity of cultural narratives of dementia and old age.
On the statistical power of Baarda’s outlier test and some alternative
Authors: Lehmann R. , Voß-Böhme A. 
Published: May 2017

Abstract
Baarda’s outlier test is one of the best established theories in geodetic practice. The optimal test statistic of the local model test for a single outlier is known as the normalized residual. Also other model disturbances can be detected and identified with this test. It enjoys the property of being a uniformly most powerful invariant (UMPI) test, but is not a uniformly most powerful (UMP) test. In this contribution we will prove that in the class of test statistics following a common central or non-central χ2 distribution, Baarda’s solution is also uniformly most powerful, i.e. UMPχ2 for short. It turns out that UMPχ2 is identical to UMPI, such that this proof can be seen as another proof of the UMPI property of the test. We demonstrate by an example that by means of the Monte Carlo method it is even possible to construct test statistics, which are regionally more powerful than Baarda’s solution. They follow a so-called generalized χ2 distribution. Due to high computational costs we do not yet propose this as a ”new outlier detection method”, but only as a proof that it is in principle possible to outperform the statistical power of Baarda’s test.
Hydrographic survey of a south Florida canal using a hydrolite
Authors: Berber M. , Wright W. 
Published: May 2017

Abstract
In this study, a hydrographic map of a South Florida canal is prepared using RTK GPS (Real Time Kinematic Global Positioning System) measurements combined with a hydrolite (single beam echo sounder). RTK GPS measurements are made using both single RTK and Network RTK systems. Digital sounding measurements taken by hydrolite are compared to manual lead line measurements. Single RTK and Network RTK results differed in the order of tenth of a foot accuracy for horizontal coordinates and for height measurements variations can go up to several tenths. Sounding results indicate a best-fit trend line with a slope of 0.993, and an R squared value of 0.972, demonstrating that hydrolite measurements and manually collected depths at this site are well correlated.
The crystal structure of 1,2-bis[2-methyl-5-(3-cyanophenyl)-3-thienyl]-3,3,4,4,5,5-hexafluoro-cyclopent-1-ene, C29H16F6N2S2
Authors: Lei Luo-Na , Xu Wen-Yuan , Yi Jian-Min 
Published: May 2017

Abstract
C29H16F6N2S2, monoclinic, C2/c, a = 18.910(3) Å, b = 8.5720(14) Å, c = 16.757(3) Å, β = 100.474(2)°, V = 2670.9(7) Å3, Z = 4, R
gt(F) = 0.0825 , wR
ref(F
2) = 0.1833 , T = 296(2) K.
Crystal structure of 1,1-bis(η
5-adamantylcyclopentadienyl)-3-phenyl-2-trimethylsilyl-2,3-dihydroisotitanazole, C42H55NSiTi
Authors: Manßen Manfred , Schmidtmann Marc , Beckhaus Rüdiger 
Published: May 2017

Abstract
C42H55NSiTi, triclinic, P1̅ (no. 2), a = 9.2556(4) Å, b = 12.5048(5) Å, c = 15.7350(7) Å, α = 69.6151(13)°, β = 85.3502(14)°, γ = 83.8861(14)°, V = 1695.51(13) Å3, Z = 2, R
gt(F) = 0.0334, wR
ref(F
2) = 0.0885, T = 100(2) K.
Transposon‐driven transcription is a conserved feature of vertebrate spermatogenesis and transcript evolution
Authors: Davis Matthew P , Carrieri Claudia , Saini Harpreet K , van Dongen Stijn , Leonardi Tommaso , Bussotti Giovanni , Monahan Jack M , Auchynnikava Tania , Bitetti Angelo , Rappsilber Juri , Allshire Robin C , Shkumatava Alena , O'Carroll Dónal , Enright Anton J 
Published: May 2017

AbstractSpermatogenesis is associated with major and unique changes to chromosomes and chromatin. Here, we sought to understand the impact of these changes on spermatogenic transcriptomes. We show that long terminal repeats (LTRs) of specific mouse endogenous retroviruses (ERVs) drive the expression of many long non‐coding transcripts (lncRNA). This process occurs post‐mitotically predominantly in spermatocytes and round spermatids. We demonstrate that this transposon‐driven lncRNA expression is a conserved feature of vertebrate spermatogenesis. We propose that transposon promoters are a mechanism by which the genome can explore novel transcriptional substrates, increasing evolutionary plasticity and allowing for the genesis of novel coding and non‐coding genes. Accordingly, we show that a small fraction of these novel ERV‐driven transcripts encode short open reading frames that produce detectable peptides. Finally, we find that distinct ERV elements from the same subfamilies act as differentially activated promoters in a tissue‐specific context. In summary, we demonstrate that LTRs can act as tissue‐specific promoters and contribute to post‐mitotic spermatogenic transcriptome diversity.
ZBTB48 is both a vertebrate telomere‐binding protein and a transcriptional activator
Authors: Jahn Arne , Rane Grishma , Paszkowski‐Rogacz Maciej , Sayols Sergi , Bluhm Alina , Han Chung‐Ting , Draškovič Irena , Londoño‐Vallejo José Arturo , Kumar Alan Prem , Buchholz Frank , Butter Falk , Kappei Dennis 
Published: May 2017

AbstractTelomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated by the CST complex and HOT1/HMBOX1, while subtelomeric variant repeats are recognized by NR2C/F transcription factors. Recently, the Kruppel‐like zinc finger protein ZBTB48/HKR3/TZAP has been described as a novel telomere‐associated factor in the vertebrate lineage. Here, we show that ZBTB48 binds directly both to telomeric and to subtelomeric variant repeat sequences. ZBTB48 is found at telomeres of human cancer cells regardless of the mode of telomere maintenance and it acts as a negative regulator of telomere length. In addition to its telomeric function, we demonstrate through a combination of RNAseq, ChIPseq and expression proteomics experiments that ZBTB48 acts as a transcriptional activator on a small set of target genes, including mitochondrial fission process 1 (MTFP1). This discovery places ZBTB48 at the interface of telomere length regulation, transcriptional control and mitochondrial metabolism.
Tamoxifen reduces hepatic VLDL production and GH secretion in women: a possible mechanism for steatosis development
Authors: Birzniece Vita , Barrett P Hugh R , Ho Ken K Y 
Published: May 2017

Context
Growth hormone (GH) stimulates hepatic synthesis of very-low-density lipoproteins (VLDL), whereas hepatic steatosis develops as a result of GH deficiency. Steatosis is also a complication of tamoxifen treatment, the cause of which is not known. As tamoxifen inhibits the secretion and action of GH, we hypothesize that it induces steatosis by inhibiting hepatic VLDL export.

Aim
To investigate whether tamoxifen reduces hepatic VLDL secretion.

Design
Eight healthy, normolipidemic women (age: 64.4 ± 2.1 years) were studied in random sequence at baseline, after 2 weeks of tamoxifen (20 mg/day) and after 2 weeks of estradiol valerate (EV; 2 mg/day) treatments, separated by a 4-week washout period. The kinetics of apolipoprotein B (apoB), the structural protein of VLDL particles, were measured using a stable isotope 2H3-leucine turnover technique. VLDL-apoB fractional catabolic rate (FCR) was determined using a multicompartment model. VLDL-apoB secretion was estimated as the product of FCR and VLDL-apoB concentration. GH response to arginine stimulation, circulating levels of IGF-1, FFA, and TG, along with TG content in VLDL were measured.

Results
Tamoxifen significantly (P < 0.05) reduced VLDL-apoB concentration and secretion by 27.3 ± 7.8% and 29.8 ± 10.2%, respectively. In contrast, EV did not significantly change VLDL-apoB concentration or secretion. Tamoxifen but not EV significantly reduced (P < 0.05) GH response to arginine stimulation. Both treatments significantly lowered (P < 0.05) circulating IGF-1.

Conclusion
Inhibition of VLDL secretion may contribute to the development of fatty liver during tamoxifen therapy. As GH stimulates VLDL secretion, the development of steatosis may arise secondarily from GH insufficiency induced by tamoxifen.