bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promise and peril in nanomedicine: the challenges and needs for integrated systems biology approaches to define health risk
Authors: Halappanavar Sabina , Vogel Ulla , Wallin Hakan , Yauk Carole L 
Published: March 2017

In the 1966s visionary film ‘Fantastic Voyage’ a submarine crew was shrunk to 100 nm in size and injected into the body of an injured scientist to repair his damaged brain. The movie (written by Harry Kleiner; directed by Richard Fleischer; novel by Isaac Asimov) drew attention to the potential power of engineered nanoscale structures and devices to construct, monitor, control, treat, and repair individual cells. Even more interesting was the fact that the film elegantly noted that the structure had to be miniaturized to a size that is not detected by the body's immune surveillance system, and highlighted the many physiological barriers that are encountered on the submarine's long journey to the target. Although the concept of miniaturizing humans remains an element of science fiction, targeted drug delivery through nanobots to treat diseases such as cancer is now a reality. The ability of nanobots to evade immune surveillance is one of the most attractive features of nanoscale materials that are exploited in the field of medicine for molecular diagnostics, targeted drug delivery, and therapy of diseases. This article will provide a concise opinion on the state‐of‐the‐art, the challenges, and the use of systems biology—another equally revolutionary field of science—to assess the unique health hazards of nanomaterial exposures. WIREs Nanomed Nanobiotechnol 2018, 10:e1465. doi: 10.1002/wnan.1465This article is categorized under:

Therapeutic Approaches and Drug Discovery > Emerging Technologies
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
Protein corona and nanoparticles: how can we investigate on?
Authors: Pederzoli Francesca , Tosi Giovanni , Vandelli Maria Angela , Belletti Daniela , Forni Flavio , Ruozi Barbara 
Published: March 2017

Nanoparticles (NPs) represent one of the most promising tools for drug‐targeting and drug‐delivery. However, a deeper understanding of the complex dynamics that happen after their in vivo administration is required. Particularly, plasma proteins tend to associate to NPs, forming a new surface named the ‘protein corona’ (PC). This surface is the most exposed as the ‘visible side’ of NPs and therefore, can have a strong impact on NP biodistribution, targeting efficacy and also toxicity. The PC consists of two poorly delimited layers, known as ‘hard corona’ (HC) and ‘soft corona’ (SC), that are affected by the complexity of the environment and the formed protein‐surface equilibrium during in vivo blood circulation. The HC corona is formed by proteins strongly associated to the NPs, while the SC is an outer layer consisting of loosely bound proteins. Several studies attempted to investigate the HC, which is easier to be isolated, but yielded poor reproducibility, due to varying experimental conditions. As a consequence, full mapping of the HC for different NPs is still lacking. Moreover, the current knowledge on the SC, which may play a major role in the ‘first’ interaction of NPs once in vivo, is very limited, mainly due to the difficulties in preserving it after purification. Therefore, multi‐disciplinary approaches leading to the obtainment of a major number of information about the PC and its properties is strongly needed to fully understand its impact and to better support a more safety and conscious application of nanotechnology in medicine. WIREs Nanomed Nanobiotechnol 2017, 9:e1467. doi: 10.1002/wnan.1467This article is categorized under:

Therapeutic Approaches and Drug Discovery > Emerging Technologies
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Measurement of K fluorescence yields of niobium and rhodium using monochromatic radiation
Authors: Riffaud Jonathan , Lépy Marie‐Christine , Ménesguen Yves , Novikova Anastasiia 
Published: March 2017

Both reactions Nb‐93(n,n′)Nb‐93 m and Rh‐103(n,n′)Rh‐103 m are of particular importance for dosimetry in reactor, and the measurement of the activity of Nb and Rh dosimeters provides the basic data that can be traced back to the reactor operating information. These radionuclides emit only X‐rays of which emission intensities in recommended data are determined thanks to the γ‐ray transition probabilities and fluorescence yield values. In general, the knowledge of fluorescence yields is rather poor and based on old measurements. Nowadays, the use of tunable monochromatic X‐ray sources allows performing optimized measurements. In a first step, accurate values of the attenuation coefficients are measured at the metrology beam line of the SOLEIL synchrotron, using procedures such as optimized for similar measurements. In a second step, the fluorescence yields are determined using experimental approaches in a traditional experimental configuration. For both materials, several incident energies are used to get experimental spectra with energy‐dispersive spectrometer. The peaks of interest are processed using the COLEGRAM software, which allows detailed fitting of the peak shape. The K fluorescence yields are derived with about 2% relative uncertainty. Copyright © 2017 John Wiley & Sons, Ltd.
Family Structure Experiences and Child Socioemotional Development During the First Nine Years of Life: Examining Heterogeneity by Family Structure at Birth
Authors: Bzostek Sharon H. , Berger Lawrence M. 
Published: March 2017

AbstractA vast amount of literature has documented negative associations between family instability and child development, with the largest associations being in the socioemotional (behavioral) domain. Yet, prior work has paid limited attention to differentiating the role of the number, types, and sequencing of family transitions that children experience, as well as to understanding potential heterogeneity in these associations by family structure at birth. We use data from the Fragile Families and Child Wellbeing Study and hierarchical linear models to examine associations of family structure states and transitions with children’s socioemotional development during the first nine years of life. We pay close attention to the type and number of family structure transitions experienced and examine whether associations differ depending on family structure at birth. For children born to cohabiting or noncoresident parents, we find little evidence that subsequent family structure experiences are associated with socioemotional development. For children born to married parents, we find associations between family instability and poorer socioemotional development. However, this largely reflects the influence of parental breakup; we find little evidence that socioemotional trajectories differ for children with various family structure experiences subsequent to their parents’ breakup.
The FinTech Revolution and Financial Regulation: The Case of Online Supply-Chain Financing
Authors: TSAI Chang-hsien , PENG Kuan-Jung 
Published: March 2017

AbstractOnline supply-chain financing has been a relatively novel funding channel for suppliers as small- and medium-sized enterprises (“SMEs”) to obtain loans in that the revolution of financial technology (“FinTech”) transforms traditional supply-chain financing, which used to be administered only by official banks, to an online model also used by electronic commerce platforms (“e-commerce platform”). Endeavours towards financial inclusion of the underserved SMEs could rationalize why we should allow for or encourage FinTech innovations exemplified by the online supply-chain financing mentioned above. What would be an adaptive regulatory regime for such innovative FinTech-enabled financial services as the online supply-chain financing? Within our conceptual framework to regulate the FinTech industry at the early stage, rather than rigorous rules traditionally placed on large financial institutions, a principles-based strategy should be adopted to strike a balance between financial stability and access to financial services advanced by disruptive innovations. As a necessary complement, regulatory sandboxes would be needed to spur a shift in institutional philosophy to a principles-based regulatory regime. In other words, the regulatory attitude of FinTech regulation should be humble and light-touch to promote innovation for improving digital financial inclusion, albeit on the premise of containing potential systemic risk and protecting consumer interest in the meantime.
Variable future-time reference in French: A comparison of learners in a study-abroad and a foreign-language context
Authors: Gudmestad Aarnes , Edmonds Amanda 
Published: March 2017

AbstractThis study seeks to advance understanding of second-language (L2) acquisition of future-time reference in French, by comparing the developmental trajectories of learners living in and away from the target-language setting. Study-abroad learners in France (n= 45), foreign-language learners living in the US (n= 37), and native speakers of Hexagonal French (n= 30) participated in this study. They completed a written-contextualized task, a language-proficiency test and a background questionnaire. For each written-contextualized-task item, participants selected from among three responses that differed with respect to the form (inflectional future, periphrastic future, present). Items were designed to test for the influence of three factors on the form selected: presence/absence of a lexical temporal indicator, temporal distance, and (un)certainty. Additionally, two extra-linguistic factors were examined: learning context and proficiency level. The analyses of frequency and the multinomial logistic regressions suggest that, despite developmental similarities between learning contexts, acquisitional paths of study-abroad and foreign-language learners were not identical.
Carbapenem-ResistantEnterobacteriaceae: A Strategic Roadmap for Infection Control
Authors: Friedman N. Deborah , Carmeli Yehuda , Walton Aaron Lea , Schwaber Mitchell James 
Published: March 2017

The incidence of carbapenem-resistantEnterobacteriaceae(CRE) has increased worldwide with great regional variability. Infections caused by these organisms are associated with crude mortality rates of up to 70%. The spread of CRE in healthcare settings is both an important medical problem and a major global public health threat. All countries are at risk of falling victim to the emergence of CRE; therefore, a preparedness plan is required to avoid the catastrophic natural course of this epidemic. Proactive and adequate preventive measures locally, regionally, and nationally are required to contain the spread of these bacteria. The keys to success in preventing the establishment of CRE endemicity in a region are early detection through targeted laboratory protocols and containment of spread through comprehensive infection control measures. This guideline provides a strategic roadmap for infection control measures based on the best available evidence and expert opinion, to enable preparation of a multifaceted preparedness plan to abort epidemics of CRE.Infect Control Hosp Epidemiol2017;38:580–594
Outcome and cost analysis of bilateral sequential same-day cartilage tympanoplasty compared with bilateral staged tympanoplasty
Authors: Olusesi AD , Oyeniran O 
Published: March 2017

AbstractBackground:Few studies have compared bilateral same-day with staged tympanoplasty using cartilage graft materials.Methods:A prospective randomised observational study was performed of 38 chronic suppurative otitis media patients (76 ears) who were assigned to undergo bilateral sequential same-day tympanoplasty (18 patients, 36 ears) or bilateral sequential tympanoplasty performed 3 months apart (20 patients, 40 ears). Disease duration, intra-operative findings, combined duration of surgery, post-operative graft appearance at 6 weeks, post-operative complications, re-do rate and relative cost of surgery were recorded.Results:Tympanic membrane perforations were predominantly subtotal (p = 0.36, odds ratio = 0.75). Most grafts were harvested from the conchal cartilage and fewer from the tragus (p = 0.59, odds ratio = 1.016). Types of complication, post-operative hearing gain and revision rates were similar in both patient groups.Conclusion:Surgical outcomes are not significantly different for same-day and bilateral cartilage tympanoplasty, but same-day surgery has the added benefit of a lower cost.
Examining the feasibility of implementing behavioural economics strategies that encourage home dinner vegetable intake among low-income children
Authors: Leak Tashara M , Swenson Alison , Rendahl Aaron , Vickers Zata , Mykerezi Elton , Redden Joseph P , Mann Traci , Reicks Marla 
Published: March 2017

AbstractObjectiveTo examine the feasibility of implementing nine behavioural economics-informed strategies, or ‘nudges’, that aimed to encourage home dinner vegetable intake among low-income children.DesignCaregivers were assigned six of nine strategies and implemented one new strategy per week (i.e. 6 weeks) during three dinner meals. Caregivers recorded child dinner vegetable intake on the nights of strategy implementation and rated the level of difficulty for assigned strategies. Baseline data on home vegetable availability and child vegetable liking were collected to assess overall strategy feasibility.SettingParticipants’ homes in a large Midwestern metropolitan area, USA.SubjectsLow-income caregiver/child (aged 9–12 years) dyads (n 39).ResultsPairwise comparisons showed that child dinner vegetable intake for the strategy ‘Serve at least two vegetables with dinner meals’ was greater than intake for each of two other strategies: ‘Pair vegetables with other foods the child likes’ and ‘Eat dinner together with an adult(s) modelling vegetable consumption’. Overall, caregivers’ mean rating of difficulty for implementing strategies was 2·6 (1=‘not difficult’, 10=‘very difficult’). Households had a mean of ten different types of vegetables available. Children reported a rating ≥5 for seventeen types of vegetable on a labelled hedonic scale (1=‘hate it’, 5–6=‘it’s okay’, 10=‘like it a lot’).ConclusionsBehavioural economics-informed strategies are feasible to implement during dinner meals, with some strategies differing by how much they influence vegetable intake among low-income children in the home.
Total leaf crude protein, amino acid composition and elemental content in the USDA-ARS bamboo germplasm collections
Authors: Wang M. L. , Harrison M. L. , Tonnis B. D. , Pinnow D. , Davis J. , Irish B. M. 
Published: March 2017

AbstractBamboo shoots and leaves are valuable food sources for both humans and livestock. The USDA-ARS NPGS (National Plant Germplasm System) collections hold 93 bamboo species in 20 genera. Total leaf protein, amino acid composition and elemental content for these important genetic resources had never been quantified. Lack of nutrition information hinders germplasm utilization. The above-mentioned nutritional traits were evaluated from these 93 species in this study. Leaf protein content among bamboo species ranged from 8.12 to 16.33% with an average of 12.84%. This average was higher than 9.0% observed for switchgrass leaves, but considerably lower than 32.48% in cassava leaves. For 18 quantified amino acids, there was more than a twofold variation among the samples evaluated. For 12 quantified mineral elements, there was significant variability from the low end (4.2-fold, 2.27–9.52 mg/g calcium; 4.4-fold, 56.17–246.43 µg/g sodium) to the high end (61.5-fold, 17.67–1087.0 µg/g manganese; 40.8-fold, 42.0–1713.5 µg/g aluminium). Due to their variability in leaf nutritive value, bamboo species should be carefully chosen when they are used as a feedstock. The results from this study will be useful for the bamboo industry, producers and consumers.
Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study
Authors: Hodson L , Bhatia L , Scorletti E , Smith D E , Jackson N C , Shojaee-Moradie F , Umpleby M , Calder P C , Byrne C D 
Published: March 2017

Abstract

Background/Objective:
Treatment of subjects with non-alcoholic fatty liver disease (NAFLD) with omega-3 polyunsaturated fatty acids (FAs) suggests high levels of docosahexaenoic acid (DHA) tissue enrichment decrease liver fat content. We assessed whether changes in erythrocyte DHA enrichment (as a surrogate marker of changes in tissue enrichment) were associated with alterations in hepatic de novo lipogenesis (DNL), postprandial FA partitioning and hepatic and peripheral insulin sensitivity in a sub-study of the WELCOME trial (Wessex Evaluation of fatty Liver and Cardiovascular markers in NAFLD (non-alcoholic fatty liver disease) with OMacor thErapy).

Subjects/Methods:
Sixteen participants were randomised to 4 g/day EPA+DHA (n=8) or placebo (n=8) for 15–18 months and underwent pre- and post-intervention measurements. Fasting and postprandial hepatic FA metabolism was assessed using metabolic substrates labelled with stable-isotope tracers (2H2O and [U13C]palmitate). Insulin sensitivity was measured by a stepped hyperinsulinaemic-euglycaemic clamp using deuterated glucose. Participants were stratified according to change in DHA erythrocyte enrichment (< or ⩾2% post intervention).

Results:
Nine participants were stratified to DHA⩾2% (eight randomised to EPA+DHA and one to placebo) and seven to the DHA<2% group (all placebo). Compared with individuals with erythrocyte <2% change in DHA abundance, those with ⩾2% enrichment had significant improvements in hepatic insulin sensitivity, reduced fasting and postprandial plasma triglyceride concentrations, decreased fasting hepatic DNL, as well as greater appearance of 13C from dietary fat into plasma 3-hydroxybutyrate (all P<0.05).

Conclusions:
The findings from our pilot study indicate that individuals who achieved a change in erythrocyte DHA enrichment ⩾2% show favourable changes in hepatic FA metabolism and insulin sensitivity, which may contribute to decreasing hepatic fat content.
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity
Authors: Vaeth Martin , Yang Jun , Yamashita Megumi , Zee Isabelle , Eckstein Miriam , Knosp Camille , Kaufmann Ulrike , Karoly Jani Peter , Lacruz Rodrigo S. , Flockerzi Veit , Kacskovics Imre , Prakriya Murali , Feske Stefan 
Published: March 2017

AbstractStore-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels is critical for lymphocyte function and immune responses. CRAC channels are hexamers of ORAI proteins that form the channel pore, but the contributions of individual ORAI homologues to CRAC channel function are not well understood. Here we show that deletion of Orai1 reduces, whereas deletion of Orai2 increases, SOCE in mouse T cells. These distinct effects are due to the ability of ORAI2 to form heteromeric channels with ORAI1 and to attenuate CRAC channel function. The combined deletion of Orai1 and Orai2 abolishes SOCE and strongly impairs T cell function. In vivo, Orai1/Orai2 double-deficient mice have impaired T cell-dependent antiviral immune responses, and are protected from T cell-mediated autoimmunity and alloimmunity in models of colitis and graft-versus-host disease. Our study demonstrates that ORAI1 and ORAI2 form heteromeric CRAC channels, in which ORAI2 fine-tunes the magnitude of SOCE to modulate immune responses.
Dynamics and universal scaling law in geometrically-controlled sessile drop evaporation
Authors: Sáenz P. J. , Wray A. W. , Che Z. , Matar O. K. , Valluri P. , Kim J. , Sefiane K. 
Published: March 2017

AbstractThe evaporation of a liquid drop on a solid substrate is a remarkably common phenomenon. Yet, the complexity of the underlying mechanisms has constrained previous studies to spherically symmetric configurations. Here we investigate well-defined, non-spherical evaporating drops of pure liquids and binary mixtures. We deduce a universal scaling law for the evaporation rate valid for any shape and demonstrate that more curved regions lead to preferential localized depositions in particle-laden drops. Furthermore, geometry induces well-defined flow structures within the drop that change according to the driving mechanism. In the case of binary mixtures, geometry dictates the spatial segregation of the more volatile component as it is depleted. Our results suggest that the drop geometry can be exploited to prescribe the particle deposition and evaporative dynamics of pure drops and the mixing characteristics of multicomponent drops, which may be of interest to a wide range of industrial and scientific applications.
Experimental demonstration of photon upconversion via cooperative energy pooling
Authors: Weingarten Daniel H. , LaCount Michael D. , van de Lagemaat Jao , Rumbles Garry , Lusk Mark T. , Shaheen Sean E. 
Published: March 2017

AbstractPhoton upconversion is a fundamental interaction of light and matter that has applications in fields ranging from bioimaging to microfabrication. However, all photon upconversion methods demonstrated thus far involve challenging aspects, including requirements of high excitation intensities, degradation in ambient air, requirements of exotic materials or phases, or involvement of inherent energy loss processes. Here we experimentally demonstrate a mechanism of photon upconversion in a thin film, binary mixture of organic chromophores that provides a pathway to overcoming the aforementioned disadvantages. This singlet-based process, called Cooperative Energy Pooling (CEP), utilizes a sensitizer-acceptor design in which multiple photoexcited sensitizers resonantly and simultaneously transfer their energies to a higher-energy state on a single acceptor. Data from this proof-of-concept implementation is fit by a proposed model of the CEP process. Design guidelines are presented to facilitate further research and development of more optimized CEP systems.
One-pot synthesis of four-coordinate boron(III) complexes by the ligand-promoted organic group migration between boronic acids
Authors: Sadu Venkata S. , Bin Hye-Rin , Lee Do-Min , Lee Kee-In 
Published: March 2017

AbstractMultidisciplinary applications of four-coordinate boron(III) complexes make them very attractive and challenging research field in chemistry, biology and material sciences. The dual role played by boron atom in stabilising the chelate ligand and enhancing the π-conjugation makes them very useful as luminescent materials for organic electronics and photonics, and sensing and imaging probes for biomedical purposes. The conventional methods involve the use of diarylborinic acids or anhydrides and triaryl boranes, which are made from organometallic reagents. The strong nucleophilicity of these reagents limits the peripheral modifications onto the boron cores. Here, we report a metal-free one-pot synthesis of four-coordinate organoborons using boronic acids, which represents the first instance of ligand assisted organic group migration between boronic acids. A tetrahedral boron ‘ate’ complex capable of transferring an organic group to the adjacent sp2 boron within a boronic anhydride intermediate is proposed and preliminary mechanistic studies by MALDI-TOF and 11B NMR support this proposal. The products are available from a series of N,O-, N,N- and O,O-bidentate ligands upon a wide array of boronic acids. We anticipate that this reaction will impact the way of producing the four-coordinate organoborons, and propel a new discovery of such materials for optoelectronic and biomedical applications.