bluuebunny/crossref_metadata_2025_split huggingface dataset:
The social construction of childhood: is a minimum age of marriage attainable in plural societies?
Authors: Ada Tchoukou Julie 
Published: September 2024

AbstractThis paper explores the way in which childhood is socially constructed in the context of child marriage regulation. Despite extreme social and cultural diversity, there is a core ideology in UN human rights instruments, around which official versions of childhood pivot. International law recommends setting the minimum age of marriage at 18years. This article problematizes the progressively depoliticizing effects of a seemingly neutral regulatory drive at the heart of the UN’s promotion of a standardized construction of childhood. The immediate purpose of this article is not to offer solutions to child marriage, but to bring together some elements that may form a basis for understanding the way in which conceptions of childhood are contextually constructed. My hope is that a familiarity with these social perceptions will help to explain the present struggle and resistance to apply universal rights constructions of childhood to non-western societies.
A 3.3‐Million‐Year Record of Antarctic Iceberg Rafted Debris and Ice Sheet Evolution Quantified by Machine Learning
Authors: Jasper Claire E. , Dyer Blake , Reilly Brendan T. , Williams Trevor , Hemming Sidney , Raymo Maureen E. 
Published: September 2024

AbstractOver the last 3.3 million years, the Antarctic Ice Sheet (AIS) has undergone phases of ice sheet growth and decay, impacting sea level and climate globally. Presently, the largely marine‐terminating AIS loses mass primarily by iceberg calving and basal melt of ice shelves. Quantifying past rates and timing of AIS melt is vital to understanding future cryosphere and sea level changes. One proxy for past ice sheet instabilities is iceberg rafted debris (IRD) fluxes. However, traditional methods of IRD quantification are labor‐intensive. Here, we present a new method of identifying IRD grains in sediment core X‐ray images using a convolutional neural network machine learning algorithm. We present a 3.3‐million‐year record of AIS IRD melt events using sediment cores from International Ocean Discovery Program Sites U1536, U1537, and U1538 in the Southern Ocean's “Iceberg Alley.” We identify two increases in the IRD fluxes throughout this period, at ∼1.8 and 0.43 Ma. We propose that after 1.8 Ma, the AIS expanded and transitioned from a primarily terrestrial‐terminating to a primarily marine‐terminating ice sheet. Therefore, after 1.8 Ma, glacial terminations and AIS iceberg discharge are associated with variations in global ice volume, presumably through the mechanism of sea level and, therefore, grounding line change. The second AIS regime change occurs during the Mid‐Brunhes Event (∼0.43 Ma). After this time, there are heightened and continuous IRD fluxes at each glacial termination, indicating increased AIS size and instability after this time.
Ultrafast near-infrared pyroelectric detector based on inhomogeneous plasmonic metasurface
Authors: Lu Youyan , Liu Liyun , Gao Ruoqian , Xiong Ying , Sun Peiqing , Wu Zhanghao , Wu Kai , Yu Tong , Zhang Kai , Zhang Cheng , Bourouina Tarik , Li Xiaofeng , Liu Xiaoyi 
Published: September 2024

AbstractPyroelectric (PE) detection technologies have attracted extensive attention due to the cooling-free, bias-free, and broadband properties. However, the PE signals are generated by the continuous energy conversion processes from light, heat, to electricity, normally leading to very slow response speeds. Herein, we design and fabricate a PE detector which shows extremely fast response in near-infrared (NIR) band by combining with the inhomogeneous plasmonic metasurface. The plasmonic effect dramatically accelerates the light-heat conversion process, unprecedentedly improving the NIR response speed by 2−4 orders of magnitude to 22 μs, faster than any reported infrared (IR) PE detector. We also innovatively introduce the concept of time resolution into the field of PE detection, which represents the detector’s ability to distinguish multiple fast-moving targets. Furthermore, the spatially inhomogeneous design overcomes the traditional narrowband constraint of plasmonic systems and thus ensures a wideband response from visible to NIR. This study provides a promising approach to develop next-generation IR PE detectors with ultrafast and broadband responses.
Sub-picosecond, strain-tunable, polarization-selective optical switching via anisotropic exciton dynamics in quasi-1D ZrSe3
Authors: Suk Sang Ho , Nah Sanghee , Sajjad Muhammad , Seo Sung Bok , Chen Jianxiang , Sim Sangwan 
Published: September 2024

AbstractIn cutting-edge optical technologies, polarization is a key for encoding and transmitting vast information, highlighting the importance of selectively switching and modulating polarized light. Recently, anisotropic two-dimensional materials have emerged for ultrafast switching of polarization-multiplexed optical signals, but face challenges with low polarization ratios and limited spectral ranges. Here, we apply strain to quasi-one-dimensional layered ZrSe3 to enhance polarization selectivity and tune operational energies in ultrafast all-optical switching. Initially, transient absorption on unstrained ZrSe3 reveals a sub-picosecond switching response in polarization along a specific crystal axis, attributed to shifting-recovery dynamics of an anisotropic exciton. However, its polarization selectivity is weakened by a slow non-excitonic response in the perpendicular polarization. To overcome this limitation, we apply strain to ZrSe3 by bending its flexible substrate. The compressive strain spectrally decouples the excitonic and non-excitonic components, doubling the polarization selectivity of the sub-picosecond switching and tripling it compared to that in the tensile-strained ZrSe3. It also effectively tunes the switching energy at a shift rate of ~93 meV %-1. This strain-tunable switching is repeatable, reversible, and robustly maintains the sub-picosecond operation. First-principles calculations reveal that the strain control is enabled by momentum- and band-dependent modulations of the electronic band structure, causing opposite shifts in the excitonic and non-excitonic transitions. Our findings offer a novel approach for high-performance, wavelength-tunable, polarization-selective ultrafast optical switching.
A systematic review of deep brain stimulation for substance use disorders
Authors: Zammit Dimech David , Zammit Dimech Audrey-Ann , Hughes Mark , Zrinzo Ludvic 
Published: September 2024

Abstract
Background
Pharmaco-psychiatric techniques remain the mainstay, first line treatments in substance use disorders (SUD), assisting in detoxification but largely ineffective at reducing dependence. The path to rehabilitation and freedom from addiction often proves uncertain and laborious for both patients and their significant others. Relapse rates for multiple substances of abuse are considerable and the number of SUD patients is on the increase worldwide.

Objective
To assess efficacy of deep brain stimulation (DBS) as a therapeutic solution for SUDs.

Methods
A systematic electronic database search of PubMed and EMBASE retrieved DBS addiction-focused studies on humans, of which a total of 26 (n = 71) from 2007 to 2023 were deemed eligible, including the first randomized controlled trial (RCT) in this field. This review was prospectively registered with PROSPERO: CRD42023411631.

Results
In addressing SUDs, DBS targeting primarily the nucleus accumbens (NAcc), with or without the anterior limb of the internal capsule, presented encouraging levels of efficacy in reducing cravings and consumption, followed by remission in some subjects, but still reporting relapses in 73.2% of patients.

Conclusions
For treatment-refractory addictions DBS use seems limited to reducing cravings with a satisfactory degree of success, yet not clinically consistent in inducing abstinence, suggesting involvement of factors unaffected by DBS intervention. Furthermore, costs and the scale of the problem are such that DBS is unlikely to have a significant societal impact. Nevertheless, DBS may provide insight into the biology of addiction and is worthy of further research using increased methodological rigor, standardized outcome measures, and pre-established surgical protocols.
Insights into phosphoethanolamine cellulose synthesis and secretion across the Gram-negative cell envelope
Authors: Verma Preeti , Ho Ruoya , Chambers Schuyler A. , Cegelski Lynette , Zimmer Jochen 
Published: September 2024

AbstractPhosphoethanolamine (pEtN) cellulose is a naturally occurring modified cellulose produced by several Enterobacteriaceae. The minimal components of the E. coli cellulose synthase complex include the catalytically active BcsA enzyme, a hexameric semicircle of the periplasmic BcsB protein, and the outer membrane (OM)-integrated BcsC subunit containing periplasmic tetratricopeptide repeats (TPR). Additional subunits include BcsG, a membrane-anchored periplasmic pEtN transferase associated with BcsA, and BcsZ, a periplasmic cellulase of unknown biological function. While cellulose synthesis and translocation by BcsA are well described, little is known about its pEtN modification and translocation across the cell envelope. We show that the N-terminal cytosolic domain of BcsA positions three BcsG copies near the nascent cellulose polymer. Further, the semicircle’s terminal BcsB subunit tethers the N-terminus of a single BcsC protein in a trans-envelope secretion system. BcsC’s TPR motifs bind a putative cello-oligosaccharide near the entrance to its OM pore. Additionally, we show that only the hydrolytic activity of BcsZ but not the subunit itself is necessary for cellulose secretion, suggesting a secretion mechanism based on enzymatic removal of translocation incompetent cellulose. Lastly, protein engineering introduces cellulose pEtN modification in orthogonal cellulose biosynthetic systems. These findings advance our understanding of pEtN cellulose modification and secretion.
Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors
Authors: Clark Paula A. , Gogoi Mayuri , Rodriguez-Rodriguez Noe , Ferreira Ana C. F. , Murphy Jane E. , Walker Jennifer A. , Crisp Alastair , Jolin Helen E. , Shields Jacqueline D. , McKenzie Andrew N. J. 
Published: September 2024

AbstractInnate lymphoid cells (ILCs) are critical in maintaining tissue homeostasis, and during infection and inflammation. Here we identify, by using combinatorial reporter mice, a rare ILC progenitor (ILCP) population, resident to the small intestinal lamina propria (siLP) in adult mice. Transfer of siLP-ILCP into recipients generates group 1 ILCs (including ILC1 and NK cells), ILC2s and ILC3s within the intestinal microenvironment, but almost exclusively group 1 ILCs in the liver, lung and spleen. Single cell gene expression analysis and high dimensional spectral cytometry analysis of the siLP-ILCPs and ILC progeny indicate that the phenotype of the group 1 ILC progeny is also influenced by the tissue microenvironment. Thus, a local pool of siLP-ILCP can contribute to pan-ILC generation in the intestinal microenvironment but has more restricted potential in other tissues, with a greater propensity than bone marrow-derived ILCPs to favour ILC1 and ILC3 production. Therefore, ILCP potential is influenced by both tissue of origin and the microenvironment during development. This may provide additional flexibility during the tuning of immune reactions.
Cell swelling enhances ligand-driven β-adrenergic signaling
Authors: Sirbu Alexei , Bathe-Peters Marc , Kumar Jothi L. M. , Inoue Asuka , Lohse Martin J. , Annibale Paolo 
Published: September 2024

AbstractG protein-coupled receptors’ conformational landscape can be affected by their local, microscopic interactions within the cell plasma membrane. We employ here a pleiotropic stimulus, namely osmotic swelling, to alter the cortical environment within intact cells and monitor the response in terms of receptor function and downstream signaling. We observe that in osmotically swollen cells the β2-adrenergic receptor, a prototypical GPCR, favors an active conformation, resulting in cAMP transient responses to adrenergic stimulation that have increased amplitude. The results are validated in primary cell types such as adult cardiomyocytes, a model system where swelling occurs upon ischemia-reperfusion injury. Our results suggest that receptors’ function is finely modulated by their biophysical context, and specifically that osmotic swelling acts as a potentiator of downstream signaling, not only for the β2-adrenergic receptor, but also for other receptors, hinting at a more general regulatory mechanism.
Thermodynamic evaluation of the aerial and aqueous oxidation of Al – Mg, Al – Si and Al – Mg – Si system alloys at 298 K
Authors: Nikolaychuk Pavel Anatolyevich , Kozeschnik Ernst 
Published: September 2024

AbstractAluminum and magnesium are the lightest structural metals, and therefore, various alloys based on them are widely used in both, automotive and aerospace industries. However, aluminum and magnesium are very easily affected by atmospheric and aqueous corrosion, and, therefore, the alloying elements should enhance their corrosion stability. In this work, the thermodynamic analysis of phase and chemical equilibria involving aluminum and magnesium alloys doped with silicon in oxygen–containing air environments, as well as the analysis of chemical and electrochemical equilibria involving these alloys in aqueous environments is conducted. The phase and chemical equiliibria in the Al–Mg, Al–Si, Mg–Si, and Al–Mg–Si systems at 298 K are considered, and the thermodynamic activities of the components of common Al–Mg–Si system alloys are calculated. The invariant chemical equilibria in the systems Al–Mg–O, Al–Si–O, Mg–Si–O at 298 K are considered, the isothermal section of the state diagrams of these systems are plotted, and the oxidation scheme of the Al–Mg–Si system alloys in excess oxygen is proposed. The chemical and electrochemical equilibria in the Al–Mg–Si–H2O system at 298 K are considered and presented in form of the activity – pH and the potential – pH diagrams, and the oxidation of the Al–Mg–Si system alloys in aqueous environments is discussed.
Clinical reasoning amongst paramedics using nebulised β₂ agonists to treat acute asthma exacerbations: a qualitative study
Authors: Mortimer Craig , Nikoletou Dimitra , Ooms Ann , Williams Julia 
Published: September 2024

AbstractThe heterogeneous nature of asthma results in a wide range of presentations during exacerbation. Despite UK pre-hospital management guidelines focusing on β₂ agonists, variables such as cause, severity, underlying health, comorbidities, and drug side effects can often make emergency treatment optimisation difficult. This article examines paramedics’ methods of observing, perceiving, interpreting, and treating asthma with β₂ agonists, often acting on limited information in rapidly evolving situations. We recruited paramedics from a single UK National Health Service ambulance Trust for qualitative semi-structured interviews. Responses underwent framework analysis to identify data similarities and differences. Fifteen qualitative interviews with paramedics revealed three main themes affecting patient management: clinician experience of presentation, adaptation of patient management approaches, and severity of side effects. Paramedics felt their ability to manage various asthma presentations was enhanced through guideline adaptation based on their own clinical experience and understanding of β₂ agonist side effects, allowing tailored responses based on a set of reinforcing factors. Inductive analysis revealed additional complexities within these themes, such as anxiety and diabetes, which may influence β₂ agonist administration and result in multiple care pathways being initiated during exacerbation. Paramedic care mirrors asthma’s complexity, accounting for a range of characteristics. A dynamic, critically thought approach enables patient management to be based on the presenting conditions rather than strict adherence to a single algorithm. Comprehending the complexities and variables in treatment can be crucial to how paramedics rationalise their treatment and optimise the care provided.
An ecological approach to understanding transitions and tensions in complex learning contexts
Authors: McCrone Luke , Kingsbury Martyn 
Published: September 2024

AbstractThe move away from transmission-based lecturing toward a more student-centred active learning approach is well evidenced in STEM higher education. However, the examination of active learning has generally remained confined to formal timetabled contexts, with assumptions made that students independently manage the transition between timetabled and non-timetabled learning. This paper introduces research findings from a mixed methods study that used an ecological approach when investigating student transitions between a formal lecture theatre and adjacent informal breakout space in a UK STEM university. Using quantitative occupancy monitoring data to analyse usage patterns of both spaces, in combination with qualitative ethnographic observations and field interviews, permitted a purposeful exploration of student engagement with transitions within and between the two learning spaces. The ecological approach aided the discovery of spatial, pedagogic and agentic transitions and tensions, which subsequently informed strategic modification of space across the institution to facilitate the adoption of active learning pedagogy.
An intranuclear bacterial parasite of deep-sea mussels expresses apoptosis inhibitors acquired from its host
Authors: Porras Miguel Ángel González , Assié Adrien , Tietjen Målin , Violette Marlene , Kleiner Manuel , Gruber-Vodicka Harald , Dubilier Nicole , Leisch Nikolaus 
Published: September 2024

AbstractA limited number of bacteria are able to colonize the nuclei of eukaryotes. ‘Candidatus Endonucleobacter’ infects the nuclei of deep-sea mussels, where it replicates to ≥80,000 bacteria per nucleus and causes nuclei to swell to 50 times their original size. How these parasites are able to replicate and avoid apoptosis is not known. Dual RNA-sequencing transcriptomes of infected nuclei isolated using laser-capture microdissection revealed that ‘Candidatus Endonucleobacter’ does not obtain most of its nutrition from nuclear DNA or RNA. Instead, ‘Candidatus Endonucleobacter’ upregulates genes for importing and digesting sugars, lipids, amino acids and possibly mucin from its host. It likely prevents apoptosis of host cells by upregulating 7–13 inhibitors of apoptosis, proteins not previously seen in bacteria. Comparative phylogenetic analyses revealed that ‘Ca. Endonucleobacter’ acquired inhibitors of apoptosis through horizontal gene transfer from their hosts. Horizontal gene transfer from eukaryotes to bacteria is assumed to be rare, but may be more common than currently recognized.
Sub-attosecond-precision optical-waveform stability measurements using electro-optic sampling
Authors: Hussain Syed A. , Hofer Christina , Högner Maximilian , Schweinberger Wolfgang , Buberl Theresa , Bausch Daniel , Huber Marinus , Krausz Ferenc , Pupeza Ioachim 
Published: September 2024

AbstractThe generation of laser pulses with controlled optical waveforms, and their measurement, lie at the heart of both time-domain and frequency-domain precision metrology. Here, we obtain mid-infrared waves via intra-pulse difference-frequency generation (IPDFG) driven by 16-femtosecond near-infrared pulses, and characterise the jitter of sub-cycle fractions of these waves relative to the gate pulses using electro-optic sampling (EOS). We demonstrate sub-attosecond temporal jitter at individual zero-crossings and sub-0.1%-level relative amplitude fluctuations in the 10-kHz–0.625-MHz band. Chirping the nearly-octave-spanning mid-infrared pulses uncovers wavelength-dependent attosecond-scale waveform jitter. Our study validates EOS as a broadband (both in the radio-frequency and the optical domains), highly sensitive measurement technique for the jitter dynamics of optical waveforms. This sensitivity reveals outstanding stability of the waveforms obtained via IPDFG and EOS, directly benefiting precision measurements including linear and nonlinear (infrared) field-resolved spectroscopy. Furthermore, these results form the basis toward EOS-based active waveform stabilisation and sub-attosecond multi-oscillator synchronisation/delay tracking.
Genetic polymorphisms in FABP2, CYP2E1, and TP53 genes are potentially associated with colorectal cancer susceptibility
Authors: Ijaz Maryam , Chen Chien-Chin , Iqbal Rana Khalid , Farooq Hafiza Aneela , Mehmood Rubaida , Asif Muhammad , Akbar Atif , Khan Adil , Ijaz Waseem , Said Mourad Ben , Wondmie Gezahign Fentahun , Ibenmoussa Samir , Okla Mohammad K. , Iqbal Furhan 
Published: September 2024

AbstractColorectal cancer (CRC) is among the most prevalent cancers with a high mortality rate. Both genetic and environmental factors contribute to CRC development. This study aimed to assess the association of single nucleotide polymorphisms (SNPs) in the fatty acid binding protein-2 (rs1799883), Cytochrome P450 2E1 (rs3813865), TP53 (rs1042522), and Murine double minute 2 (rs1042522) genes with CRC. A cross-sectional case–control study was conducted at the Institute of Molecular Biology and Biotechnology from May 2020 to March 2021, involving CRC patients (N = 100) and controls (N = 100) recruited from the Multan district in Pakistan. Polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) and tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) were employed to investigate the studied SNPs. The association of SNPs in all genes with CRC was examined either individually or in various combinations. Genotypes at three SNPs, rs1799883 in FABP2, rs3813865 in CYP2E1, and rs1042522 in TP53, were found to be associated with the development of CRC, while rs1042522 in MDM2 was not. Patients who were married, smoked, lacked exercise habits or had a family history of CRC were at a greater risk of acquiring the disease. FABP2 gene rs1799883, CYP2E1 gene rs3813865, and TP53 gene rs1042522 polymorphisms are significant in the development of CRC in Pakistani participants.