bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of a quick pregnancy test on whole blood in early pregnancy units: a prospective cohort study
Authors: Legoupil Caroline , Enderle Isabelle , Le Baccon Flore-Anne , Bendavid Claude , Peltier Lucas , Bauville Estelle , Leveque Jean , Lavoue Vincent , Le Lous Maela 
Published: September 2017

Objective
To assess the diagnostic performance of the NG-Test human chorionic gonadotropin (hCG) WB, which is a new point-of-care (POC) hCG whole-blood test.

Materials and methods
This prospective study included women consulted in early pregnancy units for vaginal bleeding and/or pelvic pain with unknown pregnancy status after medical consultation including a pelvic ultrasound scan. A new POC test (the NG-Test hCG WB) and the usual laboratory serum test (considered the gold standard) were performed in patients. The results were interpreted in a blinded manner. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for the NG-Test hCG WB.

Results
During the study period, 200 patients were included. The pregnancy rate was 17%. For the laboratory test, with a 5 UI/l hCG positivity threshold, the sensitivity, specificity, PPV, NPV, and Youden index of the NG-Test hCG WB were 89.7, 100, 100, 97.9, and 0.90%, respectively. Considering a 10 UI/l hCG positivity threshold, test sensitivity, specificity, PPV, NPV, and Youden index were 96.3, 100, 100, 99.3, and 0.96%, respectively. False-negative cases were either extremely brief pregnancies or residual hCG after miscarriage. The result was obtained within 5 min with the NG-Test hCG WB versus 90±31 min with the laboratory test. It was easy to use.

Conclusion
The NG-Test hCG WB showed a high sensitivity, specificity, PPV, and NPV. Its use as triage in the case of a negative pelvic ultrasound exam is a potential strategy to improve patient flow, with an average time saving of 85 min.
Postoperative Changes After Closed Reduction of Nasal Fracture
Authors: Lim Hyoseob , Kang Kwang Rae , Koh Sung Hoon , Jung Sung Won , Jung Soyeon 
Published: September 2017

Abstract
Nasal bone fracture is the most common facial fracture; however, surgery does not guarantee reduction and complications, such as undercorrection, overcorrection, and deviation, may occur. By analyzing findings of computed tomography (CT) immediately and at 3 months postoperatively, we evaluated the accuracy of reduction and long-term changes to the nasal bone.
Patients with pure nasal bone fracture were evaluated from January 1, 2010 to December 31, 2011. First, we categorized fracture types according to the Stranc-Robertson classification system, using preoperative CT findings (ie, F1, F2, L1, and L2). We categorized each result of reduction by immediate postoperative CT scan findings as “Excellent,” “Good,” “Fair,” and “Poor,” with “Excellent” and “Good” ratings being considered a “Success.” We evaluated changes to the nasal bone at 3 months after reduction, using the same grade.
A total of 128 patients were analyzed. The results of patients in the F1 group were better than those of other patients immediately postoperatively, whereas those of the L2 group were worse. The overall success rate was 49.2% (58/118). At 3 months postoperatively, 33 cases exhibited an improvement to a higher grade, whereas 25 cases improved from an unacceptable outcome to a successful outcome, with the overall success rate being 70.3% (83/118).
Immediately postoperative CT scans can be helpful for surgeons in determining whether a secondary adjustment is necessary. Incompletely reduced nasal bone showed spontaneous improvement in bony arrangement according to our study, so simple observation could be a choice.
Examination of Nasolacrimal Duct Morphometry Using Cone Beam Computed Tomography in Patients With Unilateral Cleft Lip/Palate
Authors: Altun Oğuzhan , Dedeoğlu Numan , Avci Mehmet 
Published: September 2017

Objective:
The cleft lip/palate (CLP) deformity negatively affects the anatomy of the nasal cavity and maxilla. The effects of this deformity on the lacrimal system have been unidentified yet. This study aimed to evaluate the morphometric changes in the nasolacrimal duct using cone-beam computed tomography (CBCT) in patients with unilateral CLP.

Materials and Methods:
Retrospective bilateral measurements of the narrowest transversal diameters and the lengths of the nasolacrimal ducts were made for the affected and unaffected sides of 28 patients with CLP and 28 control patients, using the CBCT images. The measurements were statistically compared.

Results:
The mean narrowest transversal diameter of the nasolacrimal duct for the affected side of the patients with unilateral CLP was statistically significantly narrower than the unaffected side (P = 0.01). There were no statistically significant differences between the control group and the affected and unaffected sides of patient group with unilateral CLP regarding the nasolacrimal duct diameter. The differences were not statistically significant among all groups regarding the mean nasolacrimal duct length.

Conclusion:
The diameter of the nasolacrimal duct at the affected side of unilateral CLP was narrower than the unaffected side. According to this result, the CLP deformity can have an effect on the nasolacrimal duct diameter. However, CLP might not affect the nasolacrimal duct length.
Large-Scale Study of Long-Term Anteroposterior Stability in a Surgery-First Orthognathic Approach Without Presurgical Orthodontic Treatment
Authors: Jeong Woo Shik , Lee Jang Yeol , Choi Jong Woo 
Published: September 2017

Abstract
Presurgical orthodontic treatment has long been known as a prerequisite in the traditional orthognathic approach. However, achieving ideal decompensation is very difficult even in the presurgical orthodontic period. For minimization of this problem, the surgery-first orthognathic concept has been introduced. The authors hypothesized that this treatment modality will be feasible for skeletal class III dentofacial deformity patients. In this study, the authors tried to compare the traditional and surgery-first approaches regarding long-term outcomes in terms of stability, based on large-scale data. The patients included in this study had skeletal class III dentofacial deformities, and all underwent, and completed, orthognathic surgery between December 2007 and December 2015. The inclusion criteria were based on presurgical simulation on the dental model, and the authors predicted the potential of the surgery-first approach by this preoperative simulation model. Patients with cleft-related syndromes, those who underwent orthognathic surgeries due to facial asymmetry or class II deformity were excluded from the study. In total, 104 class III patients were enrolled in the surgery-first group and 51 class III patients in the traditional orthodontic-first group. Satisfactory results were achieved in all 155 patients with dentofacial deformity in this study. Overall, the analysis revealed that anteroposterior skeletal long-term stability in the surgery-first approach was not different, statistically or otherwise, from that in the orthodontic-first approach. Anteroposterior skeletal stability was maintained well in the surgery-first approach. In conclusion, surgery-first approach without presurgical orthodontic treatment can achieve similar results of long-term anteroposterior stability in correcting dentofacial deformities as the orthodontic treatment-first approach.
Simultaneous Reconstruction of Both Facial Paralysis and Temporomandibular Joint Ankylosis With a Composite Flap From Dorsum of Foot
Authors: Akdag Osman , Evin Seyda Guray , Karamese Mehtap , Tosun Zekeriya 
Published: September 2017

Abstract
Free extensor digitorum brevis muscle flap in facial paralysis, and the second metatarsophalangeal joint flap is used at the temporomandibular joint reconstruction for a long time. Anatomically, these flaps can be harvested through even the same pedicle flap even on the same regions. Literature is available of their usage along with the use of hand and upper extremity reconstruction. Unlike this example, the authors have used these flaps in maxillofacial region where facial paralysis and temporomandibular joint reconstruction will be performed together. In this study, clinical report and surgical details of this flap have been shared.
Use of a Balloon Catheter With Intraoperative C-Arm Fluoroscan for Reduction of Zygomatic Arch Fractures
Authors: Noh Woon Jae , Park Tae Jung , Kim Joo Yeon , Kwon Jae Hwan 
Published: September 2017

Background and Objectives:
The purpose of this study was to evaluate the usefulness of C-arm fluoroscan with a balloon catheter in patients undergoing closed reduction of zygomatic arch fractures.

Subjects and Methods:
All patients who had zygomatic arch reduction surgery between 2006 and 2015 were identified and classified into 2 groups. Group A included those patients who underwent closed reduction of zygomatic arch fractures. Group B included those who underwent zygomatic arch reduction surgery with a C-arm fluoroscan and supporting balloon. A balloon catheter was used to stabilize the zygomatic bone after reduction. Results were scored from 1 (poor) to 3 (good) to assess surgical outcomes based on 3 criteria: alignment of the zygomatic arch on a postoperative computed tomography scan, facial asymmetry in photography, and the patient's subjective satisfaction.

Results:
The authors enrolled 32 patients with zygomatic arch fractures. 18 patients underwent closed reduction for zygomatic arch fractures (group A), while 14 patients underwent closed reduction with C-arm fluoroscan and balloon support (group B). The average score for group A was 2.00 for alignment, 2.56 for facial asymmetry, and 2.67 for subjective satisfaction compared with 2.64 for alignment, 2.86 for facial asymmetry, and 2.79 for subjective satisfaction in group B. There were statistically significant differences in the alignment and facial asymmetry scores between the 2 groups.

Conclusion:
The authors suggest that C-arm fluoroscan with balloon support is a useful modality for reduction of zygomatic arch fractures that provides better surgical outcomes than conventional closed reduction surgery.
Nasal Deviation in Patients With Asymmetric Mandibular Prognathism
Authors: Shin Young-Min , Lee Sung-Tak , Nam Ki-Young , Kwon Tae-Geon 
Published: September 2017

Purpose:
This study was aimed to evaluate the nasal deviation in patients with asymmetric mandibular prognathism.

Materials and Methods:
Thirty-five patients with skeletal class III malocclusion were included in the study. Significant mandibular asymmetry of >4 mm menton deviation in three-dimensional (3D) reformatted cone beam computed tomography images was defined as asymmetry group (n = 20). Patients without mandibular asymmetry served as control group (n = 15). The mandibular asymmetry was evaluated pre- and postoperatively.

Results:
Nasal tip was significantly shifted to the deviated side of the mandible (short side) in the asymmetry group, as compared to the control group (1.5 ± 0.9 degree, P < 0.01). Alar base angle (ABA) was significantly narrower in nondeviated side (long side) than in the deviated side in asymmetry group. However, control group showed no bilateral difference in ABA. Correction of deviated mandibular prognathism by isolated mandibular surgery resulted in change in the ABA but not the columella base position or nasal asymmetry. ABA on nondeviated side significantly decreased in proportion to the amount of transverse menton movement by surgery (r = −0.560, P < 0.01).

Conclusion:
Our results showed that mandibular chin deviation was accompanied by nasal deviation. Isolated mandibular surgery can potentially influence the alar base position on the contralateral side of deviation but not the nasal tip asymmetry. Therefore, clinicians should inform patients preoperatively of the fundamental limitation of mandibular surgery in cases with preexisting nasal asymmetry.
Removal of Hazardous Surgical Smoke Using a Built-in-Filter Trocar: A Study in Laparoscopic Rectal Resection
Authors: Hahn Koo Yong , Kang Dong Woo , Azman Zairul Azwan Mohd , Kim Se-Young , Kim Seon-Hahn 
Published: September 2017

Background:
Surgical smoke containing potentially carcinogenic and harmful materials is an inevitable consequence of surgical energy devices, and constitutes a substantial occupational hazard in the operating room. This study aimed to evaluate the efficacy of a built-in-filter trocar in eliminating hazardous surgical smoke during laparoscopic and robotic rectal surgery.

Methods:
Ten patients who underwent rectal cancer resection were enrolled. Five patients underwent surgery utilizing a nonfiltered trocar, and the remaining 5 utilized a built-in-filter trocar. Gas samples were aspirated from the peritoneal cavity over 30 minutes of electrocauterization and collected in a Tedlar bag. Concentrations of surgical smoke were measured using ultraperformance liquid chromatography and gas chromatography.

Results:
Eleven hazardous chemical compounds (benzene, toluene, ethylbenzene, xylene, styrene, formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde, isovaleraldehyde, and valeraldehyde) were identified in the surgical smoke. With the built-in-filter trocar, removal rates of 69% for benzene (P=0.028), 72% for toluene (P=0.009), 67% for butyraldehyde (P=0.047), 46% for ethylbenzene (P=0.092), 44% for xylene (P=0.086), 35% for styrene (P=0.106), 39% for formaldehyde (P=0.346), and 33% for propionaldehyde (P=0.316) were achieved.

Conclusions:
This study confirmed the presence of harmful materials in surgical smoke. Evacuation of surgical smoke through a disposable built-in-filter trocar is a simple and effective way in reducing volatile organic compounds concentrations.
Temporal dissociation of salience and prediction error responses to appetitive and aversive taste
Authors: Hird E. , El-Deredy W. , Jones A. , Talmi D. 
Published: September 2017

AbstractThe feedback-related negativity, a frontocentral event-related potential (ERP) occurring 200350 milliseconds (ms) after emotionally-valued outcomes, has been posited as the neural correlate of reward prediction error, a key component of associative learning. Recent evidence challenged this interpretation and has led to the suggestion that this ERP expresses salience, instead. Here we distinguish between utility prediction error and salience by delivering or withholding hedonistically matched appetitive and aversive tastes, and measure ERPs to cues signalling each taste. We observed a typical FRN (computed as the loss-minus-gain difference wave) to appetitive taste, but a reverse-FRN to aversive taste. When tested axiomatically, frontocentral ERPs showed a salience response across tastes, with a particularly early response to outcome delivery, supporting recent propositions of a fast, unsigned and unspecific response to salient stimuli. ERPs also expressed aversive prediction error peaking at 285ms, which conformed to the logic of an axiomatic model of prediction error. With stimuli that most resemble those used in animal models we did not detect any frontocentral ERP signal for utility prediction error, in contrast with dominant views of the functional role of the feedback-related negativity ERP. We link the animal and human literature and present a challenge for current perspectives on associative learning research using ERPs.
Characterising undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis
Authors: Johnson Kate M. , Bryan Stirling , Ghanbarian Shahzad , Sin Don D. , Sadatsafavi Mohsen 
Published: September 2017

SummaryBackgroundA significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterising these patients can increase our understanding of the ‘hidden’ burden of COPD and the effectiveness of case detection interventions.MethodsWe conducted a systematic review and meta-analysis to compare patient and disease risk factors between patients with undiagnosed persistent airflow limitation and those with diagnosed COPD. We searched MEDLINE and EMBASE for observational studies of adult patients meeting accepted spirometric definitions of COPD. We extracted and pooled summary data on the proportion or mean of each risk factor among diagnosed and undiagnosed patients (unadjusted analysis), and coefficients for the adjusted association between risk factors and diagnosis status (adjusted analysis). This protocol is registered with PROSPERO (CRD42017058235).Findings2,083 records were identified through database searching and 16 articles were used in the meta-analyses. Diagnosed patients were less likely to have mild (v. moderate to very severe) COPD (odds ratio [OR] 0·30, 95% CI 0·24-0·37, 6 studies) in unadjusted analysis. This association remained significant but its strength was attenuated in the adjusted analysis (OR 0·72, 95% CI 0·58-0·89, 2 studies). Diagnosed patients were more likely to report respiratory symptoms such as wheezing (OR 3·51, 95% CI 2·19-5·63, 3 studies) and phlegm (OR 2·16, 95% CI 1·38-3·38, 3 studies), had more severe dyspnoea (modified Medical Research Council scale mean difference 0·52, 95% CI 0·40-0·64, 3 studies) and slightly greater smoking history than undiagnosed patients. Patient age, sex, current smoking status, and the presence of coughing were not associated with a previous diagnosis.InterpretationPatients with undiagnosed persistent airflow limitation had less severe airflow obstruction and fewer respiratory symptoms than diagnosed patients. This indicates that there is lower disease burden among undiagnosed patients compared to those with diagnosed COPD, which may significantly delay the diagnosis of COPD.FundingCanadian Institutes of Health Research.Declaration of interestsWe declare no competing interests.Author ContributionsMS, SB, and KJ formulated the study idea and designed the study. KJ and SG performed all data analyses and MS, SB and DS contributed to interpretation of findings. KJ wrote the first draft of the manuscript. All authors critically commented on the manuscript and approved the final version. MS is the guarantor of the manuscript.
CPdock: The Complementarity Plot for Docking of Proteins: Implementing Multi-dielectric Continuum Electrostatics
Authors: Basu Sankar 
Published: September 2017

AbstractThe Complementarity plot (CP) is an established validation tool for protein structures, applicable to both, globular proteins (folding) as well as protein-protein complexes (binding). It computes the shape and electrostatic complementarities (Sm, Em) for amino acid side-chains buried within the protein interior or interface and plots them in a two-dimensional plot having knowledge-based probabilistic quality estimates for the residues as well as for the whole structure. The current report essentially presents an upgraded version of the plot with the implementation of the advanced multi-dielectric functionality (as in Delphi version 6.2 or higher) in the computation of electrostatic complementarity to make the validation tool physico-chemically more realistic. The two methods (single‐ and multi-dielectric) agrees decently in their resultant Emvalues and hence, provisions for both methods have been kept in the software suite. So to speak, the global electrostatic balance within a well-folded protein and / or a well-packed interface seems only marginally perturbed by the choice of different internal dielectric values. However, both from theoretical as well as practical grounds, the more advanced multi-dielectric version of the plot is certainly recommended for potentially producing more reliable results. The report also presents a new methodology and a variant plot, namely, CPdock, based on the same principles of complementarity, specifically designed to be used in the docking of proteins. The efficacy of the method to discriminate between good and bad docked protein complexes have been tested on a recent state-of-the-art docking benchmark. The results unambiguously indicate that CPdockcan indeed be effective in the initial screening phase of a docking scoring pipeline before going into more sophisticated and computationally expensive scoring functions. CPdockhas been made available athttps://github.com/nemo8130/CPdock
Or22 allelic variation alone does not explain differences in discrimination of yeast-produced volatiles byD. melanogaster
Authors: Elya Carolyn , Quan Allison S. , Schiabor Kelly M. , Eisen Michael B. 
Published: September 2017

AbstractDifferent lines of the fruit flyDrosophila melanogastershow variation in the ability to discriminate between volatiles produced by the yeastSaccharomyces cerevisiaeunder natural (nitrogen-limiting, YVN) or laboratory (sugar-limiting, YVL) conditions. Previous work in our laboratory uncovered a strong correlation between heightened sensitivity to YVN wildD. melanogasterlines that harbored a chimeric variant of the highly variable odorant receptor 22 (Or22) locus ofD. melanogaster. We sought to determine if this trend held for an extended set ofD. melanogasterlines, if observed variation within chimeric and non-chimeric lines could be explained by nucleotide polymorphisms and if replacing Or22 with a chimeric allele in a non-chimeric background could confer the enhanced ability to detect YVN. In parallel, we performed crosses of chimeric and non-chimeric fly lines and assayed the behavior of their progeny for enhanced sensitivity to YVN to assess the heritability of the Or22 locus. Ultimately, we found that, while the overall trend of increased sensitivity to YVN in chimeric lines persists, there are exceptions and variation that cannot be explained by sequence variation at the Or22 locus. In addition, we did not observe increased sensitivity for YVN upon replacing the Or22 allele in a non-chimeric line (OreR) with that from our most YVN-sensitive, chimeric line (ME). Though our results do not support our hypothesis that Or22 is the primary driver of sensitivity to YVN, Or22 remains an interesting locus in the context of fly-yeast ecology.
Hiring ex-offenders? The case of Ban the Box
Authors: Griffith Jakari N. , Young Nicole C. Jones 
Published: September 2017

PurposeThe purpose of this paper is to identify factors that affect how managers assess the importance of criminal history for job seekers with criminal records in Ban the Box states.Design/methodology/approachThis study uses a phenomenological investigative approach to examine narrative interview data obtained from 18 human resource (HR) professionals in organizations in five Ban the Box states.FindingsContrary to previous research, the findings presented in this paper show that managers are inclined to hire applicants with a criminal history. However, study findings indicate that those hiring decisions are positively influenced by: perceived value of criminal history; concerns about safety and cost; characteristics of the offense; motivation to hire; and evidence of applicant growth. Furthermore, a lack of systematic evaluation processes among hiring managers may present a barrier to employment.Originality/valueThis paper explores a poorly understood area of the HR management and employment inclusion literatures – the identification of factors that influence evaluations of applicants with a criminal history.