bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza hospitalizations in Australian children
Authors: LI-KIM-MOY J. , YIN J. K. , BLYTH C. C. , KESSON A. , BOOY R. , CHENG A. C. , MACARTNEY K. 
Published: February 2017

SUMMARYAustralia's National Immunisation Program (NIP) provides free influenza vaccination for children at high risk of severe influenza; a pilot-funded programme for vaccine in all children aged 6 months to <5 years in one of eight states, has seen poor vaccine impact, related to recent vaccine safety concerns. This retrospective review examined influenza hospitalizations in children aged <16 years from three seasons (2011–2013) at two paediatric hospitals on opposite sides of the country. Comparisons of this cohort were made with state-based data on influenza-coded hospitalizations and national immunization register data on population-level immunization coverage. Of 740 hospitalizations, the majority were aged <5 years (476/740, 64%), and a substantial proportion (57%) involved healthy children, not currently funded for influenza vaccine. Intensive care unit admission occurred in 8·5%, and 1·5% of all children developed encephalitis. Use of antiviral therapy was uncommon (20·5%) and decreasing. Of those hospitalized, only 5·0% of at-risk children, who are currently eligible for free vaccine, and 0·7% of healthy children were vaccinated prior to hospitalization. This was consistent with low population-wide estimates of influenza vaccine uptake. It highlights the need to examine alternative strategies, such as universally funded paediatric influenza vaccination, to address disease burden in Australian children.
Assessment of community awareness and risk perceptions of zoonotic causes of abortion in cattle at three selected livestock–wildlife interface areas of Zimbabwe
Authors: NDENGU M. , DE GARINE-WICHATITSKY M. , PFUKENYI D. M. , TIVAPASI M. , MUKAMURI B. , MATOPE G. 
Published: February 2017

SUMMARYA study was conducted to assess the awareness of cattle abortions due to brucellosis, Rift Valley fever (RVF) and leptospirosis, and to compare frequencies of reported abortions in communities living at the periphery of the Great Limpopo Transfrontier Conservation Area in southeastern Zimbabwe. Three study sites were selected based on the type of livestock–wildlife interface: porous livestock–wildlife interface (unrestricted); non-porous livestock–wildlife interface (restricted by fencing); and livestock–wildlife non-interface (totally absent or control). Respondents randomly selected from a list of potential cattle farmers (N = 379) distributed at porous (40·1%), non-interface (35·5%) and non-porous (26·4%), were interviewed using a combined close- and open-ended questionnaire. Focus group discussions were conducted with 10–12 members of each community. More abortions in the last 5 years were reported from the porous interface (52%) and a significantly higher per cent of respondents from the porous interface (P < 0·05) perceived wildlife as playing a role in livestock abortions compared with the other interface types. The odds of reporting abortions in cattle were higher in large herd sizes (odds ratio (OR) = 2·6; 95% confidence interval (CI) 1·5–4·3), porous (OR = 1·9; 95% CI 1·0–3·5) and non-porous interface (OR = 2·2; 95% CI 1·1–4·3) compared with livestock–wildlife non-interface areas. About 21·6% of the respondents knew brucellosis as a cause of abortion, compared with RVF (9·8%) and leptospirosis (3·7%). These results explain to some extent, the existence of human/wildlife conflict in the studied livestock–wildlife interface areas of Zimbabwe, which militates against biodiversity conservation efforts. The low awareness of zoonoses means the public is at risk of contracting some of these infections. Thus, further studies should focus on livestock–wildlife interface areas to assess if the increased rates of abortions reported in cattle may be due to exposure to wildlife or other factors. The government of Zimbabwe needs to launch educational programmes on public health awareness in these remote areas at the periphery of transfrontier conservation areas where livestock–wildlife interface exists to help mitigate the morbidity and mortality of people from some of the known zoonotic diseases.
Tide gauge observations in Antarctica (1958–2014) and recent ice loss
Authors: Galassi G. , Spada G. 
Published: February 2017

AbstractSeveral historical sea level time series from Antarctic tide gauges, available from the Permanent Service for Mean Sea Level, are analysed. Two sea level curves, obtained by averaging data from the Antarctic Peninsula and West Antarctica, for 1958–2014, show trends of (2.0±0.1) and (1.8±0.2) mm yr-1, respectively. By empirical mode decomposition, cyclic and non-cyclic components of sea level change were separated. A periodicity of 4–5 years was confirmed and attributed to the effects of the Antarctic Circumpolar Wave. The non-cyclic components were found to show a ‘levelling off’ of ≈ 1 mm yr-1 since c. 2000, which cannot be attributed to the isostatic response to Holocene ice melting. Using assessed mass balance data from the West Antarctic Ice Sheet and the Antarctic Peninsula, we studied the response to current ice loss in the region and found that the levelling off could be partly explained by accelerated melting during the last approximately two decades. This may represent the first evidence of sea level fingerprints of glacial melting in Antarctica.
Interactive programming in Agda – Objects and graphical user interfaces
Authors: ABEL ANDREAS , ADELSBERGER STEPHAN , SETZER ANTON 
Published: February 2017

AbstractWe develop a methodology for writing interactive and object-based programs (in the sense of Wegner) in dependently typed functional programming languages. The methodology is implemented in the ooAgda library. ooAgda provides a syntax similar to the one used in object-oriented programming languages, thanks to Agda's copattern matching facility. The library allows for the development of graphical user interfaces (GUIs), including the use of action listeners.Our notion of interactive programs is based on the IO monad defined by Hancock and Setzer, which is a coinductive data type. We use asizedcoinductive type which allows us to write corecursive programs in a modular way. Objects are server-side interactive programs that respond to method calls by giving answers and changing their state. We introduce two kinds of objects: simple objects and IO objects. Methods in simple objects are pure, while method calls in IO objects allow for interactions before returning their result. Our approach also allows us to extend interfaces and objects by additional methods.We refine our approach to state-dependent interactive programs and objects through which we can avoid exceptions. For example, with a state-dependent stack object, we can statically disable the pop method for empty stacks. As an example, we develop the implementation of recursive functions using a safe stack. Using a coinductive notion of object bisimilarity, we verify basic correctness properties of stack objects and show the equivalence of different stack implementations. Finally, we give a proof of concept that our interaction model allows to write GUI programs in a natural way: we present a simple drawing program, and a program which allows the users to move a small spaceship using a button.
The essence of ornaments
Authors: DAGAND PIERRE-EVARISTE 
Published: February 2017

AbstractFunctional programmers from all horizons strive to use, and sometimes abuse, their favorite type system in order to capture the invariants of their programs. A widely used tool in that trade consists in defining finely indexed datatypes. Operationally, these typesclassifythe programmer's data, following the ML tradition. Logically, these typesenforcethe program invariants in a novel manner. This new programming pattern, by which one programsoverinductive definitions to account for some invariants, lead to the development of a theory of ornaments (McBride, 2011Ornamental Algebras, Algebraic Ornaments. Unpublished). However, ornaments originate as a dependently-typed object and may thus appear rather daunting to a functional programmer of the non-dependent kind. This article aims at presenting ornamentsfrom first-principlesand, in particular, to declutter their presentation from syntactic considerations. To do so, we shall give a sufficiently abstract model of indexed datatypes by means of many-sorted signatures. In this process, we formalize our intuition that an indexed datatype is the combination of a data-structureand a data-logic. Over this abstraction of datatypes, we shall recast the definition of ornaments, effectively giving a model of ornaments. Benefiting both from the operationalandabstract nature of many-sorted signatures, ornaments should appear applicable and, one hopes, of interest beyond the type-theoretic circles, case in point being languages with generalized abstract datatypes or refinement types.
Impact of two policy interventions on dietary diversity in Ecuador
Authors: Ponce Juan , Ramos-Martin Jesus 
Published: February 2017

AbstractObjectiveTo differentiate the effects of food vouchers and training in health and nutrition on consumption and dietary diversity in Ecuador by using an experimental design.DesignInterventions involved enrolling three groups of approximately 200 randomly selected households per group in three provinces in Ecuador. Power estimates and sample size were computed using the Optimal Design software, with a power of 80 %, at 5 % of significance and with a minimum detectable effect of 0·25 (sd). The first group was assigned to receive a monthly food voucher of $US 40. The second group was assigned to receive the same $US 40 voucher, plus training on health and nutrition issues. The third group served as the control. Weekly household values of food consumption were converted into energy intake per person per day. A simple proxy indicator was constructed for dietary diversity, based on the Food Consumption Score. Finally, an econometric model with three specifications was used for analysing the differential effect of the interventions.SettingThree provinces in Ecuador, two from the Sierra region (Carchi and Chimborazo) and one from the Coastal region (Santa Elena).SubjectsMembers of 773 households randomly selected (n4343).ResultsNo significant impact on consumption for any of the interventions was found. However, there was evidence that voucher systems had a positive impact on dietary diversity. No differentiated effects were found for the training intervention.ConclusionsThe most cost-effective intervention to improve dietary diversity in Ecuador is the use of vouchers to support family choice in food options.
The Mediational Effect of Weight Self-Stigma in the Relationship between Blatant and Subtle Discrimination and Depression and Anxiety
Authors: Magallares Alejandro , Bolaños-Rios Patricia , Ruiz-Prieto Inmaculada , Benito de Valle Pilar , Irles Jose Antonio , Jáuregui-Lobera Ignacio 
Published: February 2017

AbstractObesity may be considered a social stigma. In addition, people with obesity are frequently aware of stigma directed at others who have a similar weight and come to think stigmatized thoughts about themselves. Our study focused specifically on how blatant and subtle discrimination and weight self-stigma are related to depression and anxiety in people with obesity. The sample comprised 170 participants from the Clinical Nutrition Unit of the “Hospital de Valme” (Seville, Spain). The Weight Self-Stigma Questionnaire, the Multidimensional Perceived Discrimination Scale, and the Hospital Anxiety and Depression Scale were used. It was found that blatant and subtle discrimination and weight self-stigma were positively related to depression (.31, .38, and .45 respectively) and anxiety (.30, .36, and .49 respectively; all ps < .01). The path analysis conducted showed that there was a mediational effect of weight self-stigma between blatant (β = .36) and subtle discrimination (β = .40) and depression (β = .24) and anxiety (β = .49; all ps < .01). According to these results, it can be said that weight self-stigma was a full mediator in the model found because the relationships between the independent and the dependent variables were non-significant. Finally, results are discussed in the frame of the obesity stigma literature, and some clinical implications of the results of the study are suggested.
Influence of Core Affect in the Differential Efficacy of a Personality Disorder Intervention Program
Authors: Ramos Juan M. , Sendra Juan M. , Sánchez Aintzane , Mena Ana 
Published: February 2017

AbstractThe usual emotional experience of the person (affective style) is an influential factor in therapeutic assimilation. Based on a dynamic model of affect shaped dimensionally by the valence and arousal axes (core affect) that fluctuate over time according to the specific context of the individual, its relationship with different variables was investigated and the changes after a 6-month intervention in a specialized hospital unit (N = 103) were observed. The orthogonal structure of core-affect was confirmed. Emotional valence appeared to be positively related to social skills (r = .375; p < .01) and self-esteem (r = .491; p < .01) and negatively to depressive symptoms (r = –.631; p < .01), general disturbance (r = –.395; p < .01) and suicidality (r = –.490; p < .01). Emotional arousal is associated with impulsivity (r = .345; p < .01). The group of patients with an affective style characterized by negative valence and low arousal core-affect gained less therapeutic benefit compared to those with positive valence core-affect (p < .05). Throughout the treatment, valence became more positive (d = .26; IC 95%: 1.9 – 7.2; p = .001), arousal increased (d = .23; IC 95%: 0.2 – 1.7; p = .015) and variability decreased (d = –.44; IC 95%: (–2.9) – (–1.1); p = .001). Changes in the core-affect are related to therapeutic improvement. Adjusting expectations of change can reduce therapeutic frustration, which is as common as it is harmful in the treatment of severe personality disorders.
Prevalence of Mental Disorders in the Elderly in the Community of Madrid: Results of the Mentdis_ICF65+ Study
Authors: Ausín Berta , Muñoz Manuel , Santos-Olmo Ana Belén , Pérez-Santos Eloísa , Castellanos Miguel A. 
Published: February 2017

AbstractThe MentDis_ICF65+ Project is an epidemiological study of mental disorders in people 65 to 85 years old in several European cities, including Madrid. Its aim is to determine the lifetime, 12-month, and 1-month prevalence of the main mental disorders in the elderly. The relationship of age and sex with each mental disorder was examined. The sample was collected through random sampling of people over 65 in Madrid, and consisted of 555 persons between 65 and 85 years old. The CIDI65+ was administered. Estimates of prevalence and odds ratios (OR) were made using sample frequencies and according to sex and age. Excluding nicotine dependence, 40.12% of the sample was found to have suffered a mental disorder at some time in their lives, 29.89% in the past year, and 17.70% were currently suffering from a mental disorder. The disorders with the highest prevalence rates were anxiety disorders, alcohol-related disorders, and mood disorders. Elderly women had a higher risk of suffering an anxiety disorder (OR men/women 0.42; CI 0.25–0.68) with a significance level ofp< .001, while elderly men were more affected by any substance-related disorder (OR men/women 3.96; CI 1.62–11.07) with a significance level ofp< .001. Each disorder’s prevalence decreased with age (OR 65–74/75–85, 1.85; CI 1.25–2.75) with a significance level ofp< .01. Results show higher prevalence rates than previous studies reported. The main implications of this study, and the need to adapt mental health services for people over 65, are highlighted.
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers
Authors: Ullah M , Kuroda Y , Bartosh T J , Liu F , Zhao Q , Gregory C , Reger R , Xu J , Lee R H , Prockop D J 
Published: February 2017

AbstractOne attractive strategy to treat cancers is to deliver an exogenous enzyme that will convert a non-toxic compound to a highly toxic derivative. The strategy was tested with viral vectors but was disappointing because the efficiency of transduction into tumor cells was too low. Recent reports demonstrated that the limitation can be addressed by using tissue-derived mesenchymal stromal cells (MSCs) to deliver enzyme/prodrug systems that kill adjacent cancer cells through bystander effects. Here we addressed the limitation that tissue-derived MSCs vary in their properties and are difficult to generate in the large numbers needed for clinical applications. We prepared a Feeder Stock of MSCs from induced pluripotent stem cells (iPSs) that provided an extensively expandable source of standardized cells. We then transduced the iPS-derived MSCs to express cytosine deaminase and injected them locally into a mouse xenogeneic model of human breast cancer. After administration of the prodrug (5-fluorocytosine), the transduced iPS-MSCs both limited growth of preformed tumors and decreased lung metastases.
A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress–damage response
Authors: Bustos Patricia L , Volta Bibiana J , Perrone Alina E , Milduberger Natalia , Bua Jacqueline 
Published: February 2017

AbstractMitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in apoptosis and necrosis, modulated by cyclophilin D (CyPD), a crucial component of this protein complex. In Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, we have previously described that mitochondrial permeability transition occurs after oxidative stress induction in a cyclosporin A-dependent manner, a well-known cyclophilin inhibitor. In the present work, a mitochondrial parasite cyclophilin, named TcCyP22, which is homolog to the mammalian CyPD was identified. TcCyP22-overexpressing parasites showed an enhanced loss of mitochondrial membrane potential and loss of cell viability when exposed to a hydrogen peroxide stimulus compared with control parasites. Our results describe for the first time in a protozoan parasite that a mitochondrial cyclophilin is a component of the permeability transition pore and is involved in regulated cell death induced by oxidative stress.
Major sulfonate transporter Soa1 in Saccharomyces cerevisiae and considerable substrate diversity in its fungal family
Authors: Holt Sylvester , Kankipati Harish , De Graeve Stijn , Van Zeebroeck Griet , Foulquié-Moreno Maria R. , Lindgreen Stinus , Thevelein Johan M. 
Published: February 2017

AbstractSulfate is a well-established sulfur source for fungi; however, in soils sulfonates and sulfate esters, especially choline sulfate, are often much more prominent. Here we show that Saccharomyces cerevisiae YIL166C(SOA1) encodes an inorganic sulfur (sulfate, sulfite and thiosulfate) transporter that also catalyses sulfonate and choline sulfate uptake. Phylogenetic analysis of fungal SOA1 orthologues and expression of 20 members in the sul1Δ sul2Δ soa1Δ strain, which is deficient in inorganic and organic sulfur compound uptake, reveals that these transporters have diverse substrate preferences for sulfur compounds. We further show that SOA2, a S. cerevisiae SOA1 paralogue found in S. uvarum, S. eubayanus and S. arboricola is likely to be an evolutionary remnant of the uncharacterized open reading frames YOL163W and YOL162W. Our work highlights the importance of sulfonates and choline sulfate as sulfur sources in the natural environment of S. cerevisiae and other fungi by identifying fungal transporters for these compounds.
Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
Authors: Liu Chao , Liu Weixiao , Ye Yihong , Li Wei 
Published: February 2017

AbstractUbiquitination of a subset of proteins by ubiquitin chain elongation factors (E4), represented by Ufd2p in Saccharomyces cerevisiae, is a pivotal regulator for many biological processes. However, the mechanism of Ufd2p-mediated ubiquitination is largely unclear. Here, we show that Ufd2p catalyses K48-linked multi-monoubiquitination on K29-linked ubiquitin chains assembled by the ubiquitin ligase (Ufd4p), resulting in branched ubiquitin chains. This reaction depends on the interaction of K29-linked ubiquitin chains with two N-terminal loops of Ufd2p. Only following the addition of K48-linked ubiquitin to substrates modified with K29-linked ubiquitin chains, can the substrates be escorted to the proteasome for degradation. We demonstrate that this ubiquitin chain linkage switching reaction is essential for ERAD, oleic acid and acid pH resistance in yeast. Thus, our results suggest that Ufd2p functions by switching ubiquitin chain linkages to allow the degradation of proteins modified with a ubiquitin linkage, which is normally not targeted to the proteasome.
Proton enhanced dynamic battery chemistry for aprotic lithium–oxygen batteries
Authors: Zhu Yun Guang , Liu Qi , Rong Yangchun , Chen Haomin , Yang Jing , Jia Chuankun , Yu Li-Juan , Karton Amir , Ren Yang , Xu Xiaoxiong , Adams Stefan , Wang Qing 
Published: February 2017

AbstractWater contamination is generally considered to be detrimental to the performance of aprotic lithium–air batteries, whereas this view is challenged by recent contrasting observations. This has provoked a range of discussions on the role of water and its impact on batteries. In this work, a distinct battery chemistry that prevails in water-contaminated aprotic lithium–oxygen batteries is revealed. Both lithium ions and protons are found to be involved in the oxygen reduction and evolution reactions, and lithium hydroperoxide and lithium hydroxide are identified as predominant discharge products. The crystallographic and spectroscopic characteristics of lithium hydroperoxide monohydrate are scrutinized both experimentally and theoretically. Intriguingly, the reaction of lithium hydroperoxide with triiodide exhibits a faster kinetics, which enables a considerably lower overpotential during the charging process. The battery chemistry unveiled in this mechanistic study could provide important insights into the understanding of nominally aprotic lithium–oxygen batteries and help to tackle the critical issues confronted.
Photo-driven redox-neutral decarboxylative carbon-hydrogen trifluoromethylation of (hetero)arenes with trifluoroacetic acid
Authors: Lin Jin , Li Zhi , Kan Jian , Huang Shijun , Su Weiping , Li Yadong 
Published: February 2017

AbstractCatalytic oxidative C–H bond functionalization reactions that proceed without requiring stoichiometric amounts of external oxidants or pre-functionalized oxidizing reagents could maximize the atom- and step-economy in chemical syntheses. However, such a transformation remains elusive. Here, we report that a photo-driven catalytic process enables decarboxylative C–H trifluoromethylation of (hetero)arenes with trifluoroacetic acid as a trifluoromethyl source in good yields in the presence of an external oxidant in far lower than stoichiometric amounts (for example, 0.2 equivalents of Na2S2O8) using Rh-modified TiO2 nanoparticles as a photocatalyst, in which H2 release is an important driving force for the reaction. Our findings not only provide an approach to accessing valuable decarboxylative C–H trifluoromethylations via activation of abundant but inert trifluoroacetic acid towards oxidative decarboxylation and trifluoromethyl radical formation, but also demonstrate that a photo-driven catalytic process is a promising way to achieve external oxidant-free C–H functionalization reactions.