bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new combined parameter predicts re-treatment for coil-embolized aneurysms: a computational fluid dynamics multivariable analysis study
Authors: Fujimura Soichiro , Takao Hiroyuki , Suzuki Takashi , Dahmani Chihebeddine , Ishibashi Toshihiro , Mamori Hiroya , Yamamoto Makoto , Murayama Yuichi 
Published: December 2017

PurposeCoil embolization is a minimally invasive method used to treat cerebral aneurysms. Although this endovascular treatment has a high success rate, aneurysmal re-treatment due to recanalization remains a major problem of this method. The purpose of this study was to determine a combined parameter that can be useful for predicting aneurysmal re-treatment due to recanalization.MethodsPatient-specific geometries were used to retrospectively analyze the blood flow for 26 re-treated and 74 non-retreated aneurysms. Post-operatively aneurysms were evaluated at 12-month follow-up. The hemodynamic differences between the re-treatment and non-retreatment aneurysms were analyzed before and after coil embolization using computation fluid dynamics. Basic fluid characteristics, rates of change, morphological factors of aneurysms and patient-specific clinical information were examined. Multivariable analysis and logistic regression analysis were performed to determine a combined parameter—re-treatment predictor (RP).ResultsAmong examined hemodynamic, morphological, and clinical parameters, slight reduction of blood flow velocity rate in the aneurysm, slight increase of pressure rate at the aneurysmal neck and neck area, and hypertension were the main factors contributing to re-treatment. Notably, hemodynamic parameters between re-treatment and non-retreatment groups before embolization were similar: however, we observed significant differences between the groups in the post-embolization average velocity and the rate of reduction in this velocity in the aneurysmal dome.ConclusionsThe combined parameter, RP, which takes into consideration hemodynamic, morphological, and clinical parameters, accurately predicts aneurysm re-treatment. Calculation of RP before embolization may be able to predict the aneurysms that will require re-treatment.
Chemoprevention of Preclinical Breast and Lung Cancer with the Bromodomain Inhibitor I-BET 762
Authors: Zhang Di , Leal Ana S. , Carapellucci Sarah , Zydeck Kayla , Sporn Michael B. , Liby Karen T. 
Published: December 2017

Abstract
Breast cancer and lung cancer remain the top two leading causes of cancer-related deaths in women. Because of limited success in reducing the high mortality of these diseases, new drugs and approaches are desperately needed. Cancer prevention is one such promising strategy that is effective in both preclinical and clinical studies. I-BET 762 is a new bromodomain inhibitor that reversibly targets BET (bromodomain and extraterminal) proteins and impairs their ability to bind to acetylated lysines on histones, thus interrupting downstream transcription. This inhibitor has anti-inflammatory effects and induces growth arrest in many cancers and is currently under clinical trials for treatment of cancer. However, few studies have investigated the chemopreventive effects of bromodomain inhibitors. Here, we found that I-BET 762 significantly delayed tumor development in preclinical breast and lung cancer mouse models. This drug not only induced growth arrest and downregulated c-Myc, pSTAT3, and pERK protein expression in tumor cells in vitro and in vivo but also altered immune populations in different organs. These results demonstrate the promising potential of using I-BET 762 for cancer prevention and suggest the striking effects of I-BET 762 are the result of targeting both tumor cells and the tumor microenvironment. Cancer Prev Res; 11(3); 143–56. ©2017 AACR.
EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion)
Authors: Xing Lei , Yamamoto Erika , Sugiyama Tomoyo , Jia Haibo , Ma Lijia , Hu Sining , Wang Chao , Zhu Yingchun , Li Lulu , Xu Maoen , Liu Huimin , Bryniarski Krzysztof , Hou Jingbo , Zhang Shaosong , Lee Hang , Yu Bo , Jang Ik-Kyung 
Published: December 2017

Background—
The initial EROSION study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion) demonstrated that patients with acute coronary syndrome caused by plaque erosion might be stabilized with aspirin and ticagrelor without stenting for ≤1 month. However, a long-term evaluation of outcomes is lacking. The aim of this study was to assess whether the initial benefit of noninterventional therapy for patients with acute coronary syndrome caused by plaque erosion is maintained for ≤1 year.

Methods and Results—

Among 53 patients who completed clinical follow-up, 49 underwent repeat optical coherence tomography imaging at 1 year. Median residual thrombus volume decreased significantly from 1 month to 1 year (0.3 mm
3
(0.0–2.0 mm
3
] versus 0.1 mm
3
[0.0–2.0 mm
3
];
P
=0.001). Almost half of the patients (46.9%) had no residual thrombus at 1 year. Minimal effective flow area remained unchanged (2.1 mm
2
[1.5–3.8 mm
2
] versus 2.1 mm
2
[1.6–4.0 mm
2
];
P
=0.152). Among 53 patients, 49 (92.5%) remained free from major adverse cardiovascular event for ≤1 year: 3 (5.7%) patients required revascularization because of exertional angina and 1 (1.9%) patient had gastrointestinal bleeding.

Conclusions—
One-year follow-up optical coherence tomography demonstrated a further decrease in thrombus volume between 1-month and 1-year follow-up. A majority (92.5%) of patients with acute coronary syndrome caused by plaque erosion managed with aspirin and ticagrelor without stenting remained free of major adverse cardiovascular event for ≤1 year.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT02041650.
Murder and Maugham: A Neglected Subversive?
Authors: Soothill Keith 
Published: December 2017

Somerset Maugham's writings had huge audiences in the first half of the twentieth century. In much of his work the focus is on people behaving badly. What effect did his work have on his readers? This article examines his short stories, of which approximately one-fifth of the major ones have murder as their theme. Focusing on the murders that Maugham ‘creates’, the claim is that Maugham is subversive, challenging some readily made assumptions. In Maugham's scheme of things, the criminal justice system is usually inappropriate, irrelevant or produces injustice, with ‘rough justice’ usually the best that is on offer. The resourceful can get away with murder. Murder is not the most serious crime for many. Instinct rather than rationality is the best judge. Maugham also emphasises the importance of fate, thus implying we are not in control of our destinies. The article argues that popular authors, such as Maugham, may have contributed much more than is generally recognised to the developing unease about the ‘status quo’ that ultimately led to the landslide victory of the Labour government in 1945.
Neuropsychiatric manifestations are not uncommon in Indian lupus patients and negatively affect quality of life
Authors: Muhammed H , Goyal M , Lal V , Singh S , Dhir V 
Published: December 2017

Objectives The objectives of this paper are to look at the prevalence of neuropsychiatric manifestations and assess their impact on quality of life in North Indian lupus patients. Methods The study included consecutive patients with systemic lupus erythematosus (SLE) who were older than 18 years and met the SLICC 2012 criteria. A diagnosis of a neuropsychiatric syndrome was made as per ACR 1999 definitions. Manifestations occurring at any point in time after the diagnosis of SLE were considered if a reliable history and medical records were available. Quality of life was assessed by EuroQol-5D questionnaire. Means were compared by student t test for normally distributed data. Comparison of quality of life between groups was performed by the Kruskal–Wallis test and Mann–Whitney U test. Results This study included 101 patients of SLE with mean (±SD) age of 32.3 ± 10.0 years and a majority ( n = 92) were females. Mean (±SD) age of diagnosis of SLE was 27.8 ± 9.2 years and disease duration (after diagnosis) was 4.6 ± 4.5 years. Thirty-three patients had neuropsychiatric manifestations with a total of 42 events. The most common manifestation was headache (10%) followed by anxiety disorder (5%) and peripheral neuropathy (9%). Other NPSLE syndromes observed in the study are seizure (4%), cognitive dysfunction (4%), depression (4%), acute confusional state (2%), autonomic neuropathy (2%), movement disorder (1%), and mononeuritis multiplex (1%). On comparing the groups of NPSLE, nephritis, and neither, there was a significant difference in mobility, self-care, pain, and worry. On post hoc test, there was a significant difference between the NPSLE and neither group. Conclusion Neuropsychiatric manifestations significantly affect quality of life in North Indian SLE patients.
Distribution and Clustering of Cutaneous T-Cell Lymphoma (CTCL) Cases in Canada During 1992 to 2010
Authors: Ghazawi Feras M. , Netchiporouk Elena , Rahme Elham , Tsang Matthew , Moreau Linda , Glassman Steven , Provost Nathalie , Gilbert Martin , Jean Sara-Elizabeth , Roshdy Osama , Pehr Kevin , Sasseville Denis , Litvinov Ivan V. 
Published: December 2017

Background: Clustering of patients with cutaneous T-cell lymphoma (CTCL) was reported in several jurisdictions around the world. This rare cancer is known to affect spouses and in some cases multiple members of the same family. These combined results suggest the existence of external disease triggers/promoters. We recently conducted the first comprehensive analysis of CTCL incidence and mortality in Canada, which revealed case clustering in several regions. Objectives: To extend our previous analysis on CTCL incidence across Canada and to provide all the collected data on CTCL patient incidence in Canada during the period of 1992 to 2010. Methods: Clinical parameters for patients with CTCL in Canada were analyzed using 2 independent population-based cancer registries: Canadian Cancer Registry and Le Registre Québécois du Cancer. The CTCL incidence rates were examined on different geographical levels, including provinces/territories, cities, and forward sortation areas. Results: Our findings further corroborate our earlier observations of higher CTCL incidence in Newfoundland and Labrador, maritime provinces (Nova Scotia and New Brunswick), and prairie provinces (Manitoba and Saskatchewan). Also, most cities with high CTCL incidence were located in these provinces. Extensive mapping of high-incidence postal codes supports case clustering in a number of communities that are located in the proximity of industrial centres and seaports. Conclusions: Detailed analysis of CTCL incidence in Canada is critical to fully understand the burden of this disease in our country, to begin the search for a possible external trigger for this lymphoma, and to reform how health care resources are distributed throughout the country to better serve Canadian patients with CTCL.
A Practice Innovations Decision Model
Authors: Rohrer James E. 
Published: December 2017

Objective: The purpose of this commentary is to propose a flexible practice innovations decision model (PIDM) for use in health services planning and management. Method: This is an example of fuzzy decision analysis. The elements of the model are explained by applying it to the decision of whether to open a primary care clinic in retail space. The model contains 10 criteria, each of which scored as 1 (met) or 0 (not met). The scores are summed to guide the decision. Result: In this example, success was defined a priori as meeting 8 or more criteria. Sensitivity analysis and simulation can be used in practice to test the model. Conclusion: The PIDM appears to be applicable to a variety of decisions, and the fuzzy scoring combined with simulation and sensitivity analysis generates plausible results. The model should be modified as necessary for each situation in which it is applied.
Police History: A Bibliography
Authors: Parris Henry W. 
Published: December 2017

Few subjects have been as neglected by historians as the Police. Anyone studying the history of the 19th century in particular, when the modern era of policing began, cannot fail to be struck by the cursory treatment accorded to the new element in public security by the most authoritative writers. We were glad, therefore, to receive the list of publications relating to police history which Dr. Parris introduces in the following article. It is we, believe, the only published list of its kind. It may be that other matter has been published in this field and we shall be glad to print a supplementary list if any of our readers care to send particulars (in the same detail as in the present list) of any omissions, whether in book- or booklet-form or as articles in Force or other magazines.
Marine N2O Emissions From Nitrification and Denitrification Constrained by Modern Observations and Projected in Multimillennial Global Warming Simulations
Authors: Battaglia G. , Joos F. 
Published: December 2017

Nitrous oxide (N2O) is a potent greenhouse gas (GHG) and ozone destructing agent; yet global estimates of N2O emissions are uncertain. Marine N2O stems from nitrification and denitrification processes which depend on organic matter cycling and dissolved oxygen (O2). We introduce N2O as an obligate intermediate product of denitrification and as an O2‐dependent by‐product from nitrification in the Bern3D ocean model. A large model ensemble is used to probabilistically constrain modern and to project marine N2O production for a low (Representative Concentration Pathway (RCP)2.6) and high GHG (RCP8.5) scenario extended to A.D. 10,000. Water column N2O and surface ocean partial pressure N2O data serve as constraints in this Bayesian framework. The constrained median for modern N2O production is 4.5 (±1σ range: 3.0 to 6.1) Tg N yr−1, where 4.5% stems from denitrification. Modeled denitrification is 65.1 (40.9 to 91.6) Tg N yr−1, well within current estimates. For high GHG forcing, N2O production decreases by 7.7% over this century due to decreasing organic matter export and remineralization. Thereafter, production increases slowly by 21% due to widespread deoxygenation and high remineralization. Deoxygenation peaks in two millennia, and the global O2 inventory is reduced by a factor of 2 compared to today. Net denitrification is responsible for 7.8% of the long‐term increase in N2O production. On millennial timescales, marine N2O emissions constitute a small, positive feedback to climate change. Our simulations reveal tight coupling between the marine carbon cycle, O2, N2O, and climate.
Constraints on Friction, Dilatancy, Diffusivity, and Effective Stress From Low‐Frequency Earthquake Rates on the Deep San Andreas Fault
Authors: Beeler N. M. , Thomas Amanda , Bürgmann Roland , Shelly David 
Published: December 2017

AbstractFamilies of recurring low‐frequency earthquakes (LFEs) within nonvolcanic tremor on the San Andreas Fault in central California are sensitive to tidal stresses. LFEs occur at all levels of the tides, are strongly correlated and in phase with the ~200 Pa shear stresses, and weakly and not systematically correlated with the ~2 kPa tidal normal stresses. We assume that LFEs are small sources that repeatedly fail during shear within a much larger scale, aseismically slipping fault zone and consider two different models of the fault slip: (1) modulation of the fault slip rate by the tidal stresses or (2) episodic slip, triggered by the tides. LFEs are strongly clustered with duration much shorter than the semidiurnal tide; they cannot be significantly modulated on that time scale. The recurrence times of clusters, however, are many times longer than the semidiurnal, leading to an appearance of tidal triggering. In this context we examine the predictions of laboratory‐observed triggered frictional (dilatant) fault slip. The undrained end‐member model produces no sensitivity to the tidal normal stress, and slip onsets are in phase with the tidal shear stress. The tidal correlation constrains the diffusivity to be less than ~1 × 10−6/s and the product of the friction and dilatancy coefficients to be at most 5 × 10−7, orders of magnitude smaller than observed at room temperature. In the absence of dilatancy the effective normal stress at failure would be about ~55 kPa. For this model the observations require intrinsic weakness, low dilatancy, and lithostatic pore fluid.
Carrier Modulation of Ambipolar Few‐Layer MoTe2 Transistors by MgO Surface Charge Transfer Doping
Authors: Luo Wei , Zhu Mengjian , Peng Gang , Zheng Xiaoming , Miao Feng , Bai Shuxin , Zhang Xue‐Ao , Qin Shiqiao 
Published: December 2017

AbstractSemiconducting molybdenum ditelluride (2H‐MoTe2), a fast‐emerging 2D material with an appropriate band gap and decent carrier mobility, is configured as field‐effect transistors and is the focus of substantial research interest, showing hole‐dominated ambipolar characteristics. Here, carrier modulation of ambipolar few‐layer MoTe2 transistors is demonstrated utilizing magnesium oxide (MgO) surface charge transfer doping. By carefully adjusting the thickness of MgO film and the number of MoTe2 layers, the carrier polarity of MoTe2 transistors from p‐type to n‐type can be reversely controlled. The electron mobility of MoTe2 is significantly enhanced from 0.1 to 20 cm2 V−1 s−1 after 37 nm MgO film doping, indicating a greatly improved electron transport. The effective carrier modulation enables to achieve high‐performance complementary inverters with high DC gain of >25 and photodetectors based on few‐layer MoTe2 flakes. The results present an important advance toward the realization of electronic and optoelectronic devices based on 2D transition‐metal dichalcogenide semiconductors.
How to Evaluate and Manipulate Charge Transfer and Photocatalytic Response at Hybrid Nanocarbon–Metal Oxide Interfaces
Authors: Kemnade Nina , Gebhardt Paul , Haselmann Greta M. , Cherevan Alexey , Wilde Gerhard , Eder Dominik 
Published: December 2017

AbstractNanocarbon–metal oxide hybrids are among the most promising functional materials in many cutting‐edge environmental and energy applications where efficient charge separation and extraction are keys to success. The next level of hybrid structures will be achieved once one learns how to control and tune charge/energy transfer processes at the interfaces. However, little is yet known about the nature and extent of these interfacial dynamics in nanocarbon hybrids. Here a model is designed in which ultrathin dielectric layers (Al2O3, ZrO2) between the hybrid's components (ZnO, TiO2) and carbon nanotubes allow for evaluating and tuning of interfacial charge transfer over an unusually long distance of at least 50 nm. Surprisingly, the transfer efficiency correlates linearly with the barrier layer thickness, indicating that electron conduction through the barrier layer constitutes the rate‐limiting step. It is also demonstrated that the charge transfer efficiency can be tuned by the type of interlayer and its degree of crystallinity, thus controlling the hybrid's performance in the photocatalytic production of hydrogen. It is believed that this model system will help to understand and decipher the fundamentals regarding interfacial charge and energy transfer in nanocarbon hybrids with the aim to further advance these hybrid structures for a wide range of energy applications.
Directional and Continuous Transport of Gas Bubbles on Superaerophilic Geometry‐Gradient Surfaces in Aqueous Environments
Authors: Ma Hongyu , Cao Moyuan , Zhang Chunhui , Bei Zhanlin , Li Kan , Yu Cunming , Jiang Lei 
Published: December 2017

AbstractDue to the direct and sufficient contacting with the aqueous environment, the directional and continuous transport of gas bubbles on open surface without energy input will advance a variety of applications in heat transfer, selective aeration, water electrolysis, etc. Unfortunately, the behaviors of gas bubbles in aqueous environment are mainly dominated by the buoyancy moving gas bubbles upward, resulting in their difficult manipulation. Therefore, realizing the directional and continuous transport of gas bubbles on open surface still remains a great challenge. Herein, a novel strategy integrating the superaerophilic wettability with geometry‐gradient structure is proposed, which can engender high driving force and low hysteresis resistance force acting on the gas bubbles. In experiment, these fabricated superaerophilic geometry‐gradient polyethylene surfaces demonstrate distinguished performance of directionally and continuously transporting gas bubbles on open surfaces without energy input. In addition, the antibuoyancy bubble transportation device and the underwater bubble microreactor are successfully prepared in this manuscript, both of which illustrate the feasibility in the applications of complex environment and gas‐related fields. It can be envisioned that this study will promote the understanding and development of underwater functional superwettability materials to achieve the directional and continuous transport of gas bubbles on the open surface.
DNA‐Au Nanomachine Equipped with i‐Motif and G‐Quadruplex for Triple Combinatorial Anti‐Tumor Therapy
Authors: Park Hyeongmok , Kim Jinhwan , Jung Sungjin , Kim Won Jong 
Published: December 2017

AbstractIn the present study, the design, construction, and operation of a functional DNA‐decorated dynamic gold (Au) nanomachine as a therapeutic agent for triple combinatorial anti‐cancer therapy are revealed. Taking advantage of the intrinsic optical properties of Au nanoparticles, which depend on their size, a cytosine rich i‐motif sequence is employed for intracellular pH‐sensitive duplex dissociation and subsequent aggregation of the DNA‐Au nanomachine, enabling anticancer drug release and photothermal ablation upon irradiation with infrared light. Moreover, another functional DNA sequence, a G‐quadruplex, is exploited for the stable loading and intracellular delivery of a photosensitizer to achieve effective photodynamic therapy under red light illumination. The G‐quadruplex‐assisted enhanced reactive oxygen species generation, pH‐responsive dynamic aggregation behavior, consequent drug release, and the photothermal effect are investigated. Furthermore, the combinatorial chemo, photodynamic, and photothermal therapeutic effects of the functional DNA‐decorated Au nanomachines are evaluated in vitro and in vivo using a triple negative breast cancer model.
Synthesis of Sulfonated 5‐Aminopyrazoles by I2/Benzoyl Peroxide‐Mediated Tandem Reaction
Authors: Cheng Dongping , Chen Tianpeng , Xu Xiaoliang , Yan Jizhong 
Published: December 2017

AbstractThe tandem reaction of 3‐morpholinoacrylonitrile with sulfonyl hydrazides mediated by I2/benzoyl peroxide (BPO) is reported, which offers an efficient approach for the synthesis of sulfonated 5‐aminopyrazoles. It can bear a large scope of the substrates, and be used for the synthesis of aromatic, heteroaromatic and aliphatic sulfonated 5‐aminopyrazoles.magnified image