bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exclusive endoscopic tympanoplasty efficacy in the treatment of cholesteatoma without mastoid involvement
Authors: Bianconi Luca , Meneghesso Stefano , Arietti Valerio , Leonardi Giacomo , Monzani Daniele , Sacchetto Luca 
Published: September 2024

Abstract
Purpose
The purpose of this study is to determine the recurrence rate of cholesteatoma in patients who have undergone exclusive endoscopic tympanoplasty at our tertiary referral institution. A secondary objective is to analyze different clinical aspects that could be considered risk factors for recurrence to establish if it is possible to determine when a second-look procedure is indicated instead of a clinical follow-up.

Methods
A retrospective study was performed on patients who had undergone exclusive endoscopic tympanoplasty for cholesteatoma in the last eight years and who were followed up for at least one year. The efficacy of the treatment performed only with the exclusive endoscopic technique was analyzed. Then, the anamnestic and intraoperative data were studied to identify possible factors that could increase the risk of recurrence.

Results
The recurrence rate (14.5%) in patients (164) who underwent primary surgery with the exclusive endoscopic technique between January 2014 and January 2022 was similar to that in patients who underwent the microscopic technique with mastoidectomy in literature. In addition, we analyzed several clinical factors such as age, ossicular chain erosion, extension and localization of the cholesteatoma finding that only the last one could potentially be a risk factor for recurrence in this selected population.

Conclusion
Exclusive endoscopic tympanoplasty has been shown to be effective in removing cholesteatoma in patients without evidence of mastoid involvement, with recurrence rates comparable to traditional microscopic technique and a minimally invasive approach, even considering the patient’s age, ossicular chain erosion and extension of the disease.
Mechanical power distribution of the lower limbs changed during intermittent 300 countermovement jumps
Authors: Sanno Maximilian , Goldmann Jan-Peter , Heinrich Kai , Wahl Patrick , Brüggemann Gert-Peter 
Published: September 2024

Abstract

Purpose
The aim of this study was to investigate the effect of 300 intermittent countermovement jumps (CMJs) on the mechanical power distribution at the joints of the lower limbs and the influence of the upper body to explain vertical jump performance.

Methods
Fifteen male sport students (age 24.5 ± 2.3 years; body height 1.85 ± 0.06 m; body mass 84.8 ± 8.5 kg) performed a set of intermittent 300 CMJs at maximal effort. An inverse-dynamic approach was used to calculate the mechanical power at the hip, knee, and ankle joint for each jump.

Results
Jump height and mechanical power in the knee and ankle joints decreased significantly (p < .010), while remained the same in the hip joint. In contrast, a significant increased vertical velocity was observed for the upper body segment. In addition, a significant higher angular momentum at the center of mass was detected during the braking and propulsion phase.

Conclusion
The findings highlight a fatigue-related decrease in lower limb power, particularly in the knee and ankle joints, which changed the mechanical power distribution at the joints of the lower limbs. The trunk extensor muscles were probably able to counteract the fatigue-related decrease in lower limb power by increased vertical velocity of the upper body segment and higher angular momentum at the center of mass during the braking and propulsion phase. Accordingly, the most effective way to maintain jumping performance in fatigued state would be to improve the fatigue resistance of the knee extensors, ankle plantar flexors, and trunk extensor muscles.
The PATROL1 function in roots contributes to the increase in shoot biomass
Authors: Notaguchi Michitaka , Ichita Manami , Kawasoe Takaya , Monda Keina , Kurotani Ken-ichi , Higaki Takumi , Iba Koh , Hashimoto-Sugimoto Mimi 
Published: September 2024

Abstract
Main conclusion
PATOL1 contributes to increasing biomass not only by effective stomatal movement but also by root meristematic activity.

Abstract
PATROL1 (PROTON ATPase TRANSLOCATION CONTROL 1), a protein with a MUN domain, is involved in the intercellular trafficking of AHA1 H+-ATPase to the plasma membrane in guard cells. This allows for larger stomatal opening and more efficient photosynthesis, leading to increased biomass. Although PATROL1 is expressed not only in stomata but also in other tissues of the shoot and root, the role in other tissues than stomata has not been determined yet. Here, we investigated PATROL1 functions in roots using a loss-of-function mutant and an overexpressor. Cytological observations revealed that root meristematic size was significantly smaller in the mutant resulting in the short primary root. Grafting experiments showed that the shoot biomass of the mutant scion was increased when it grafted onto wild-type or overexpressor rootstocks. Conversely, grafting of the overexpressor scion shoot enhanced the growth of the mutant rootstock. The leaf temperatures of the grafted plants were consistent with those of their respective genotypes, indicating cell-autonomous behavior of stomatal movement and independent roles of PATROL1 in plant growth. Moreover, plasma membrane localization of AHA1 was not altered in root epidermal cells in the patrol1 mutant implying existence of a different mode of PATROL1 action in roots. Thus PATROL1 plays a role in root meristem and contributes to increase shoot biomass.
Reproductive development in Trithuria submersa (Hydatellaceae: Nymphaeales): the involvement of AGAMOUS-like genes
Authors: Moschin Silvia , Nigris Sebastiano , Offer Elisabetta , Babolin Nicola , Chiappetta Adriana , Bruno Leonardo , Baldan Barbara 
Published: September 2024

Abstract
Main conclusion
In the early diverging angiosperm Trithuria submersaTsAG1 and TsAG2 are expressed in different flower organs, including bracts, while TsAG3 is more ovule-specific, probably functioning as a D-type gene.

Abstract
Species of Trithuria, the only genus of the family Hydatellaceae, represent ideal candidates to explore the biology and flower evolution of early diverging angiosperms. The life cycle of T. submersa is generally known, and the “reproductive units” are morphologically well described, but the availability of genetic and developmental data of T. submersa is still scarce. To fill this gap, a transcriptome analysis of the reproductive structures was performed and presented in this work. This analysis provided sequences of MADS-box transcription factors, a gene family known to be involved in flower and fruit development. In situ hybridization experiments on floral buds were performed to describe the spatiotemporal expression patterns of the AGAMOUS genes, revealing the existence of three AG genes with different expression domains in flower organs and in developing ovules. Trithuria may offer important clues to the evolution of reproductive function among early angiosperms and Nymphaeales in particular, and this study aims to broaden relevant knowledge regarding key genes of reproductive development in non-model angiosperms, shaping first flower appearance and evolution.
GCD inequalities inspired by Vojta’s conjecture
Authors: Yasufuku Yu 
Published: September 2024

Abstract
We prove several GCD inequalities inspired by Vojta’s deep conjecture in Diophantine geometry. These inequalities work with all algebraic numbers, so they can be thought of as attempts to extend GCD inequalities for S-units obtained by Corvaja and Zannier. Some of the inequalities we derive are weakened versions of inequalities obtained by Silverman under the assumption of Vojta’s conjecture. The upper bounds for the GCD’s in these inequalities all involve some contributions of heights and some contributions coming from the local heights outside S. The main ingredient of the proofs is the recent Diophantine approximation result of Ru and Vojta which is based on Schmidt subspace theorem and which involves a birational invariant coming from the asymptotic growth of the number of global sections of certain line bundles.
Self-reported cancer-related cognitive impairment is associated with perturbed neurotransmission pathways
Authors: Oppegaard Kate R. , Conley Yvette P. , Paul Steven , Cooper Bruce , Harris Carolyn S. , Shin Joosun , Morse Lisa , Levine Jon D. , Cartwright Frances , Roy Ritu , Melisko Michelle , Kober Kord M. , Hammer Marilyn J. , Miaskowski Christine 
Published: September 2024

Abstract

Background
Cancer-related cognitive impairment (CRCI) is reported by 45% of patients with cancer. Significant gaps in knowledge remain regarding the mechanisms that underlie CRCI.

Objectives
Using a data-driven approach, the study purpose was to evaluate for perturbed pathways associated with membership in the High versus the Low CRCI profiles.

Methods
Patients completed the Attentional Function Index six times over two cycles of chemotherapy. Using findings from a previous latent profile analysis, subgroups of patients with high versus low levels of CRCI were evaluated (i.e., High versus Low CRCI profiles). Gene expression was quantified using either ribonucleic (RNA)-sequencing or microarray analyses and pathway impact analyses were performed. Signaling pathways were defined using the Kyoto Encyclopedia of Genes and Genomes database.

Results
A total of 508 patients had data available for analysis. Of the 261 patients in the RNA-sequencing sample, 48.7% were in the High class and 51.3% were in the Low class. Of the 247 patients the microarray sample, 46.6% were in the High class and 53.4% were in the Low class. Pathway impact analyses identified seven perturbed pathways related to neurotransmission (i.e., glutamatergic synapse, GABAergic synapse, dopaminergic synapse, serotonergic synapse, long-term depression, cholinergic synapse, retrograde endocannabinoid signaling).

Conclusions
This study is the first to describe associations between self-reported CRCI in patients receiving chemotherapy for breast, gastrointestinal, gynecological, or lung cancer and seven neurotransmission pathways. These findings provide new insights into potential targets for mechanistically based interventions.
Thermal tolerance of larvae of seven Chironomus species and up-regulation of heat shock protein-coding genes in Chironomus sulfurosus
Authors: Tettey Pamela A. , Fujii Sotaro , Saito Hidetoshi , Sambongi Yoshihiro , Kawai Koichiro 
Published: September 2024

Abstract
Global warming directly and indirectly affects the biology and ecology of aquatic insects. Chironomids are ubiquitous on the earth and are suitable for systematic analysis of the warming effect on insects. Here, we measured the survival rate for the fourth-instar larvae of seven Chironomus species at different temperatures. The mid-temperature for survival after 1-h temperature exposure to Chironomus sulfurosus larvae was the highest (43 °C) among seven Chironomus species. In addition, 14.5% of C. sulfurosus larvae survived at 40 °C from the first to the fourth instar for 14 days, whereas larvae of the other three species with relatively high thermal tolerance in the 1-h exposure test could not. These results indicate that only C. sulfurosus larvae are tolerant of 40 °C. We examined the expression levels of specific genes encoding four heat shock proteins and one heat shock protein cognate in C. sulfurosus larvae at various temperatures using quantitative real-time PCR. The expression levels of genes for hsc70, hsp67, hsp60, hsp27, and hsp23 genes were higher at 40 °C than those at 35 °C, at which 97% of larvae survived for 14 days. Therefore, in conjunction with the present phylogenetic analysis, the thermal tolerance of C. sulfurosus is associated with the up-regulated hsp and hsc genes, which may underlie a mechanism for the organism’s response to high temperatures.
A phenomenological analysis of the #KuyaKimAnoNa segment of the 24 Oras newscast’s graphical elements for deaf viewers
Authors: Espineda Melvin N. , Gimeno Sarah Faith A. 
Published: September 2024

AbstractThis phenomenological study, influenced by Radcliffe-Structural Brown’s Structural Functionalism and Bortha’s (2017) Minimalism Theory, explores the impact of the #KuyaKimAnoNa part of 24 Oras newscasts on deaf viewers. In-depth interviews were used to analyze the lived experiences of nine individuals. Four major themes emerged: modification of the TV inset size for deaf visual sign recognition and understanding; minimal visual components aid deaf people in understanding the message; familiarization and exposure to the deaf community’s preferred language; and simplification of the layout for better deaf perception and understanding of the message. This study concludes that changing the size of the TV inset is the only way to improve social inclusion. Deaf viewers, on the other hand, prefer a more straightforward structure. To increase their comprehension of deaf viewers’ language and signs, SLIs and multimedia practitioners must be exposed to and be familiar with the deaf community’s culture and preferred language. TV networks, on the other hand, may consider streamlining their layout into deaf-friendly designs or employing minimal graphical features to allow deaf viewers access to information and social integration; this must adhere to a structural model to be functional.
Identification and Validation of Biomarkers to Predict Early Diagnosis of Inflammatory Bowel Disease and Its Progression to Colorectal Cancer
Authors: Khan Farhat , Abdulla Naaziyah , du Plessis Thea-Leonie , Karlsson Kay , Barrow Peter , Bebington Brendan , Gu Liang , Kaur Mandeep 
Published: September 2024

AbstractInflammatory bowel disease (IBD) has become a common global health problem as prevalence continues to rise. It is often associated with increased risk of colorectal cancer (CRC) development. Limitations in current IBD biomarker-based diagnosis hinder the accuracy of early detection of CRC progression. Therefore, in this study, we proposed the use of transcription factor (TF)-based biomarkers that can potentially detect the transition of IBD to CRC. Various bioinformatic analysis and online database validations, and RT-qPCR validations were performed to identify possible diagnostic TFs. RUNX1 was identified as a promising TF that regulates 106 IBD/CRC-related genes. The incorporation of RUNX1 in combination with currently known IBD biomarkers, FEV + NFKB1 + RELA, achieved a comparable sensitivity and specificity scores of 99% and 87%, respectively, while RUNX1 in combination with known CRC markers, CEA + TIMP1 + CA724 + CA199, achieved a sensitivity and specificity score of 97% and 99%, respectively. Furthermore, a small pilot RT-qPCR-based analysis confirmed a demarcated shift in expression profiles in CA724, CEA, RUNX1 and TIMP1 in IBD patients compared to CRC patients’ tissue samples. Specifically, CA724 is noticeably elevated in IBD, while the levels of CEA, RUNX1 with TIMP1 are probable genes that may be employed in discerning IBD progression to CRC. Therefore, these preliminary results once validated in large patient cohorts could potentially have a significant impact on CRC disease stratification, resulting in a more precise prediction for treatment and treatment outcomes, especially in South African patients.
Understanding the Drivers of Industry 4.0 Technologies to Enhance Supply Chain Sustainability: Insights from the Agri-Food Industry
Authors: Zhao Guoqing , Chen Xiaoning , Jones Paul , Liu Shaofeng , Lopez Carmen , Leoni Leonardo , Dennehy Denis 
Published: September 2024

AbstractThe sustainability of agri-food supply chains (AFSCs) is severely threatened by regional and global events (e.g., conflicts, natural and human-made disasters, climate crises). In response, the AFSC industry is seeking digital solutions using Industry 4.0 (I4.0) technologies to enhance resilience and efficiency. However, why I4.0 adoption remains stubbornly low in the agri-food industry remains poorly understood. To address this gap, this study draws on middle-range theory (MRT) and uses thematic analysis, the fuzzy analytic hierarchy process, total interpretive structural modelling, and fuzzy cross-impact matrix multiplication applied to classification to produce insights from nine case studies in China that have invested in I4.0 technologies to improve their AFSC sustainability. New drivers of I4.0 unique to the agri-food industry are identified, showing how I4.0 can contribute to the environmental, economic, and social dimensions of AFSC sustainability. The results have implications for AFSC researchers and practitioners with an interest in supply chain sustainability.
Localization in Boundary-Driven Lattice Models
Authors: Giusfredi Michele , Iubini Stefano , Politi Paolo 
Published: September 2024

AbstractSeveral systems display an equilibrium condensation transition, where a finite fraction of a conserved quantity is spatially localized. The presence of two conservation laws may induce the emergence of such transition in an out-of-equilibrium setup, where boundaries are attached to different and subcritical heat baths. We study this phenomenon in a class of stochastic lattice models, where the local energy is a general convex function of the local mass, mass and energy being both globally conserved in the isolated system. We obtain exact results for the nonequilibrium steady state (spatial profiles, mass and energy currents, Onsager coefficients) and we highlight important differences between equilibrium and out-of-equilibrium condensation.
Survey of a class of iterative row-action methods: The Kaczmarz method
Authors: A. Ferreira Inês , A. Acebrón Juan , Monteiro José 
Published: September 2024

AbstractThe Kaczmarz algorithm is an iterative method that solves linear systems of equations. It stands out among iterative algorithms when dealing with large systems for two reasons. First, at each iteration, the Kaczmarz algorithm uses a single equation, resulting in minimal computational work per iteration. Second, solving the entire system may only require the use of a small subset of the equations. These characteristics have attracted significant attention to the Kaczmarz algorithm. Researchers have observed that randomly choosing equations can improve the convergence rate of the algorithm. This insight led to the development of the Randomized Kaczmarz algorithm and, subsequently, several other variations emerged. In this paper, we extensively analyze the native Kaczmarz algorithm and many of its variations using large-scale systems as benchmarks. Through our investigation, we have verified that, for consistent systems, various row sampling schemes can outperform both the original and Randomized Kaczmarz method. Specifically, sampling without replacement and using quasirandom numbers are the fastest techniques. However, for inconsistent systems, the Conjugate Gradient method for Least-Squares problems overcomes all variations of the Kaczmarz method for these types of systems.
Kinder – Jugendhilfe – Strafvollzug
Authors: Arikoglu Selin , Wagner Leonie 
Published: September 2024

ZusammenfassungDie Situation und Bedarfe von Angehörigen und insbesondere Kindern von Inhaftierten haben in der Sozialen Arbeit bislang wenig Beachtung gefunden. Der Schwerpunkt thematisiert die spezifischen Anforderungen von mehreren Seiten. Beschrieben werden die Rahmenbedingungen für Kontakte, die möglichen Auswirkungen einer Inhaftierung eines Elternteils auf Kinder, Jugendliche und Partner_innen sowie notwendige Reformen. Am Beispiel des Projekts „Freiräume“ wird eine gelungene Vater-Kind-Arbeit im Strafvollzug vorgestellt.
Incidence of contrast-induced neurotoxicity following endovascular treatment of unruptured intracranial aneurysms: a single-centre cohort study
Authors: Mariajoseph Frederick P. , Lai Leon T. , Moore Justin , Chandra Ronil V. , Goldschlager Tony , Praeger Adrian , Yu Daniel , Slater Lee-Anne 
Published: September 2024

Abstract
Background
Contrast-induced neurotoxicity (CIN) is a recognised complication of endovascular procedures and has been increasingly observed in recent years. Amongst other clinical gaps, the precise incidence of CIN is unclear, particularly following intracranial interventional procedures.

Methods
A retrospective study of consecutive patients undergoing elective endovascular treatment of unruptured intracranial aneurysms (UIAs) was performed. Patients with previously ruptured aneurysms were excluded. The primary aim of this study was to determine the incidence of CIN following endovascular UIA treatment. Our secondary aim was to isolate potential predictive factors for developing CIN.

Results
From 2017 to 2023, a total of 158 patients underwent endovascular UIA treatment, with a median age of 64 years (IQR: 54–72), and 70.3% of female sex. Over the study period, the crude incidence of CIN was 2.5% (95% CI: 0.7 – 6.4%). The most common clinical manifestation of CIN was confusion (75%) and seizures (50%). Statistical analysis was conducted, and prolonged procedural duration was found be significantly associated with developing CIN (OR 12.55; p = 0.030).

Conclusion
Clinicians should be aware of the risk of CIN following endovascular neurointervention, particularly following technically challenging cases resulting in prolonged procedural time.
Embracing Technology to Develop a Clinical Pharmacology and Medication Safety Elective in Undergraduate Medical Education
Authors: Wightkin William T. , Graham Elizabeth B. , Hooper Brooke , Ikonne Uzoma 
Published: September 2024

AbstractA clinical pharmacology and medication safety elective was developed for fourth-year medical students to enhance students’ foundational pharmacology knowledge and the importance of preventing medication errors. Using video conferencing technology represents a modern approach to facilitate vertical integration of pharmacology curricula and increase multi-institutional and interprofessional collaboration to improve student learning.
The asymmetric effect of the stabilisation policies on the general price level in the Southern African Common Monetary Area
Authors: Mashao Teboho , Choga Ireen 
Published: September 2024

AbstractFor decades, ensuring price stability has been a significant concern for the monetary authorities in emerging economies. Even though monetary policy is essential for keeping the price level stable, it is still exposed to shocks that can challenge economic objectives. As a result, the main objective of this study is to examine the asymmetric effects of stabilisation policies on the general price in the Southern African Common Monetary Area (CMA) between 1990 and 2022. The study uses panel analysis and panel nonlinear autoregressive distributed lags techniques to analyse the effects of exchange rate, money supply, government revenue, fiscal deficit, interest rate and government spending on the general price level. The results show that positive and negative changes in exchange rate, government revenue, fiscal deficit and interest rate significantly affect the general price level in the long run. However, only negative changes in interest rates and positive changes in fiscal deficit affect the price level in the long run. The long-term effect of government spending and money supply is insignificant. Furthermore, this study reports that there is a long-run asymmetric effect of the exchange rate on the general price level. The study suggests that contractive fiscal policy should be applied to avoid upward pressure on the general price level in the CMA, and a monetary policy approach should be applied to effectively control exchange rate fluctuations. Therefore, a policy mix aimed at price stability should be implemented in the CMA.