bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameters Pointing at an Increased Risk for Contralateral Hip Fractures
Authors: Moll Maria A. , Bachmann Lucas M. , Joeris Alexander , Goldhahn Joerg , Blauth Michael 
Published: December 2015

Background: Early identification of hip fracture (HF) patients bearing an increased risk for a contralateral occurrence would allow providing preventive measures timely. Objectives: To summarize the available evidence describing risk scores, prognostic instruments, or (groups of) parameters predicting contralateral HFs at the time point of the first fracture. Methods/Systematic Review: Articles were identified through searches in MEDLINE and Scopus from inception to April 2014, checking of reference lists of the included studies and reviews. One reviewer assessed all articles for inclusion and abstracted the data. Uncertain cases were discussed and decided with a second reviewer. Salient study and population characteristics were abstracted for each article. Studies reporting the association of a set of risk factors for second HFs were further examined and compared. The number of studies reporting on a risk parameter was assessed. Results: Searches identified 3560 records, and 47 studies were included in this review. There was a large spectrum of study designs, patient populations, and follow-up periods. Among 11 studies reporting on a set of parameters, female gender was assessed most commonly (7 times), followed by age (5) and parameters of general health, vision, and stroke (each 4 times). We were unable to depict stringent patterns of risk parameters to be used for decision making in clinical practice. Conclusions: The findings of this article call for a conjoint effort to achieve an expert consensus regarding a critical set of parameters for a risk instrument identifying patients bearing an increased risk for contralateral HFs early.
Increased Compliance With Supervised Rehabilitation Improves Functional Outcome and Return to Sport After Anterior Cruciate Ligament Reconstruction in Recreational Athletes
Authors: Han Fucai , Banerjee Anirban , Shen Liang , Krishna Lingaraj 
Published: December 2015

Background: Successful return to sport is an important outcome measure after anterior cruciate ligament (ACL) reconstruction and a reason for patients’ decisions to elect surgery. Rehabilitation programs supervised by physical therapists are routinely prescribed after ACL reconstruction surgery. However, the added advantage of supervised physical therapy after ACL reconstruction is still debatable. Hypothesis: Attending more supervised physical therapy sessions after arthroscopic ACL reconstruction in recreational athletes increases their chance of successful return to sport. Study Design: Cohort study; Level of evidence, 3. Methods: The authors analyzed 93 recreational athletes who underwent arthroscopic ACL reconstruction. After arthroscopic single-bundle ACL reconstruction, patients were advised to attend 20 supervised physical therapy sessions. Patients’ demographics, surgical details, and outcome measures (Knee injury and Osteoarthritis Outcome Score [KOOS], Lysholm scale, and Short Form–36 Health Survey [SF-36]) were recorded presurgery and at 1-year follow-up. Ability to return to sports was documented through patients’ self-report. The attendance at physical therapy by each patient was obtained by examining database records and assessed as fully compliant (>15 sessions), moderately compliant (6-15 sessions), or noncompliant (<6 sessions). Results: Patients in the fully compliant group had significantly greater odds (odds ratio [OR], 18.5; 95% CI, 1.9-184.5; P = .013) of a successful return to sport as compared with the noncompliant group. Patients in the moderately compliant group also had greater odds of returning to sport as compared with the noncompliant group (OR, 4.2; 95% CI, 1.0-16.6; P = .043). Patients in the fully compliant group had significantly greater scores on the Lysholm ( P < .001), KOOS Sports and Recreation subscale ( P = .021), KOOS Symptoms subscale ( P = .040), and SF-36 physical component summary (PCS) ( P = .012) as compared with the noncompliant group. Moderately compliant patients had significantly greater scores on the Lysholm ( P = .004), KOOS Sports and Recreation ( P = .026), KOOS Symptoms ( P = .041), KOOS Quality of Life ( P = .022), and SF-36 PCS ( P = .004) as compared with noncompliant patients. Conclusion: In recreational athletes, moderate to full compliance with a supervised physical therapy program predicts improved knee function and a greater chance of returning to sport 1 year after ACL reconstruction.
Managing asthma in pregnancy
Authors: Murphy Vanessa E. 
Published: December 2015

Asthma is a common comorbidity during pregnancy and its prevalence is increasing in the community. Exacerbations are a major clinical problem during pregnancy with up to 45% of women needing to seek medical help, resulting in poor outcomes for mothers and their babies, including low birth weight and preterm delivery. The goals of effective asthma management in pregnancy are to maintain the best possible asthma control and prevent exacerbations. This is achieved by aiming to prevent day- and night-time symptoms, and maintain lung function and normal activity. In addition, maintaining fetal oxygenation is an important consideration in pregnancy. Guidelines recommend providing asthma advice and review prior to conception, and managing asthma actively during pregnancy, with regular 4-weekly review, provision of a written action plan, use of preventer medications as indicated for other adults with asthma, and management of comorbid conditions such as rhinitis.Improvements have been made in recent years in emergency department management of asthma in pregnancy, and multidisciplinary approaches are being proposed to optimise both asthma outcomes and perinatal outcomes. One strategy that has demonstrated success in reducing exacerbations in pregnancy is treatment adjustment using a marker of eosinophilic lung inflammation, the exhaled nitric oxide fraction (FeNO). The use of an algorithm that adjusted inhaled corticosteroids (ICS) according toFeNOand added long-acting β-agonists when symptoms remained uncontrolled resulted in fewer exacerbations, more women on ICS but at lower mean doses, and improved infant respiratory health at 12 months of age. Further evidence is needed to determine whether this strategy can also improve perinatal outcomes and be successfully translated into clinical practice.Key pointsAsthma is the most common chronic disease to affect pregnant women.Exacerbations occur in up to 45% of pregnant women with asthma.Asthma should be managed during pregnancy as for other adults.Treatment adjustment using a marker of airway inflammation reduces the exacerbation rate in pregnancy.Educational aimsTo identify the goals of and steps associated with effective asthma management in pregnancy.To understand the maternal and perinatal risks associated with asthma during pregnancy.To describe a management strategy that has been shown to reduce exacerbations in pregnant women with asthma.
Pulmonary thrombo-embolism in pregnancy: diagnosis and management
Authors: Simcox Louise E. , Ormesher Laura , Tower Clare , Greer Ian A 
Published: December 2015

Key pointsVenous thromboembolism (VTE) in pregnancy remains a leading cause of direct maternal mortality in the developed world and identifiable risk factors are increasing in incidence.VTE is approximately 10-times more common in the pregnant population (compared with non-pregnant women) with an incidence of 1 in 1000 and the highest risk in the postnatal period.If pulmonary imaging is required, ventilation perfusion scanning is usually the preferred initial test to detect pulmonary embolism within pregnancy. Treatment should be commenced on clinical suspicion and not be withheld until an objective diagnosis is obtained.The mainstay of treatment for pulmonary thromboembolism in pregnancy is anticoagulation with low molecular weight heparin for a minimum of 3 months in total duration and until at least 6 weeks postnatal. Low molecular weight heparin is safe, effective and has a low associated bleeding risk.Educational aimsTo inform readers about the current guidance for diagnosis and management of pulmonary thromboembolism in pregnancy.To highlight the risks of venous thromboembolism during pregnancy.To introduce the issues surrounding management of pulmonary thromboembolism around labour and delivery
Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway
Authors: Yang Yi , Chen Qi-hong , Liu Ai-ran , Xu Xiu-ping , Han Ji-bin , Qiu Hai-bo 
Published: December 2015

Abstract
Background
Mesenchymal stem cells (MSCs) stabilise endothelial barrier function in acute lung injury via paracrine hepatocyte growth factor (HGF). Vascular endothelial growth factor (VEGF), which is secreted by MSCs, is another key regulator of endothelial permeability; however, its role in adjusting permeability remains controversial. In addition, whether an interaction occurs between HGF and VEGF, which are secreted by MSCs, is not completely understood.

Methods
We introduced a co-cultured model of human pulmonary microvascular endothelial cells (HPMECs) and MSC conditioned medium (CM) collected from MSCs after 24 h of hypoxic culture. The presence of VEGF and HGF in the MSC-CM was neutralised by anti-VEGF and anti-HGF antibodies, respectively. To determine the roles and mechanisms of MSC-secreted HGF and VEGF, we employed recombinant humanised HGF and recombinant humanised VEGF to co-culture with HPMECs. Additionally, we employed the RhoA inhibitor C3 transferase and the Rac1 inhibitor NSC23766 to inhibit the activities of RhoA and Rac1 in HPMECs treated with MSC-CM or VEGF/HGF with the same dosage as in the MSC-CM. Then, endothelial paracellular and transcellular permeability was detected. VE-cadherin, occludin and caveolin-1 protein expression in HPMECs was measured by western blot. Adherens junction proteins, including F-actin and VE-cadherin, were detected by immunofluorescence.

Results
MSC-CM treatment significantly decreased lipopolysaccharide-induced endothelial paracellular and transcellular permeability, which was significantly inhibited by pretreatment with HGF antibody or with both VEGF and HGF antibodies. Furthermore, MSC-CM treatment increased the expression of the endothelial intercellular adherence junction proteins VE-cadherin and occludin and decreased the expression of caveolin-1 protein. MSC-CM treatment also decreased endothelial apoptosis and induced endothelial cell proliferation; however, the effects of MSC-CM treatment were inhibited by pretreatment with HGF antibody or with both HGF and VEGF antibodies. Additionally, the effects of MSC-CM and VEGF/HGF on reducing endothelial paracellular and transcellular permeability were weakened when HPMECs were pretreated with the Rac1 inhibitor NSC23766.

Conclusion
HGF secreted by MSCs protects the endothelial barrier function; however, VEGF secreted by MSCs may synergize with HGF to stabilise endothelial cell barrier function. Rac1 is the pathway by which MSC-secreted VEGF and HGF regulate endothelial permeability.
Skeletal muscle contractile function predicts activity and behaviour in zebrafish
Authors: Seebacher Frank , Little Alexander G. , James Rob S. 
Published: December 2015

ABSTRACT
Locomotion facilitates behaviour and its underlying physiological mechanisms may therefore impact behavioural phenotypes. Metabolism is often thought to modulate locomotion and behaviour, but empirical support for this suggestion is equivocal. Muscle contractile function is directly associated with locomotion. Here, we test the hypotheses that muscle mechanics determine locomotor performance and activity in zebrafish (Danio rerio) and thereby also affect risk-taking behaviour. We show that there is a mechanistic link between muscle performance and behaviour by manipulating muscle contractile properties, which caused proportional changes in critical sustained swimming performance and, in an open arena, voluntary swimming speed, the proportion of time fish were active, and the latency to move. We modelled the relationships between muscle contractile properties, swimming performance, activity and behaviour with a partial least-squares path model. The latent variable ‘muscle’, formed by isolated muscle force production, stress, fatigue resistance and activation and relaxation rates, had a significant positive effect on swimming performance (‘swim’ reflected in sustained and sprint speeds). Together, muscle and swim had a significant positive effect on activity, and explained 71.8% of variation in the distance moved, time active and maximum voluntary speed in an open field. Activity had a significant positive effect on boldness, explaining 76.0% of variation in latencies to move and to approach a novel object. Muscle contractile function determines voluntary movement and we suggest that exploration and dispersal are functions of physiological and mechanical optimisation. Boldness therefore may be partly explained by the greater likelihood of faster fish to move further and encounter novel objects and conspecifics more quickly as a result.
Embodying metaphors: Signed language interpreters at work
Authors: Nilsson Anna-Lena 
Published: December 2015

Abstract
The present study describes how Swedish Sign Language (SSL) interpreters systematically use signing space and movements of their hands, arms and body to simultaneously layer iconic expressions of metaphors for differences and for time, in ways previously not described. This is analyzed as the interpreters embodying metaphors, and each of the conceptual metaphors they embody seems to be expressed in a distinct manner not noted before in accounts of the structure of signed languages. Data consists of recordings of Swedish-SSL interpreting by native SSL signers. Rendering spoken Swedish into SSL, these interpreters produce complex sequences making abundant use of the circumstance that in signed language you can express several types of information simultaneously. With little processing time, they produce iconic expressions, frequently using several underlying conceptual metaphors to simultaneously layer information. The interpreters place individual signs in relation to time lines in order to express metaphorical content related to time, and use movement’s of their bodies to express comparisons and contrasts. In all of the analyzed sequences, the interpreters express the metaphor difference-between-is-distance-between. In addition, they layer metaphors for difference and time simultaneously, in some instances also expressing the orientational metaphor pair more-is-up and less-is-down at the same time.
Flow of River Tigris and its Effect on the Bed Sediment within Baghdad, Iraq
Authors: Al-Ansari Nadhir , Ali Ammar A. , Al-Suhail Qusay , Knutsson Sven 
Published: December 2015

AbstractRiver Tigris is a major river in Iraq. Sediment at the bed of the river within a reach of about 18 km from the center of Baghdad upstream was investigated. Sixty five cross sections were surveyed, and 46 sediment samples were collected and analyzed. It was noticed that fine sand was dominant in the bed (90.74%). The average median size within the reach was 2.49 phi (0.177 mm), while the mean size was 2.58 phi (0.16 mm). In addition, the sediments were moderately sorted, fine skewed and leptokurtic. The size of the bed sediment decreased relative to previous investigations due to the construction of the Adhaim dam on tributary, which used to be the main sediment supplier to the Tigris River before entering Baghdad. Furthermore, the discharge of the Tigris River for the period 1983–2013 (715 m3/s) decreased by about 40% and 30%since 1983when compared with the periods 1931–1956 (1208 m3/s) and 1956–1980 (1015 m3/s), respectively, due to climate change and construction of dams upstream from Baghdad. This has decreased the capacity and the competence of the river. The bed elevation has increased compared to previous surveys. Itwas noticed that dredging operations and obstructions (e.g. fallen bridges and islands) have disturbed the flow of the river and sediment characteristics in several sites.
Peristaltic transport of a fractional Burgers’ fluid with variable
viscosity through an inclined tube
Authors: Rachid Hassan 
Published: December 2015

Abstract
In the present study,we investigate the unsteady
peristaltic transport of a viscoelastic fluid with fractional
Burgers’ model in an inclined tube. We suppose that the
viscosity is variable in the radial direction. This analysis
has been carried out under low Reynolds number and
long-wavelength approximations. An analytical solution
to the problem is obtained using a fractional calculus approach.
Figures are plotted to show the effects of angle
of inclination, Reynolds number, Froude number, material
constants, fractional parameters, parameter of viscosity
and amplitude ratio on the pressure gradient, pressure
rise, friction force, axial velocity and on the mechanical efficiency.
An approximation method for fractional
integro-differential equations
Authors: Emiroglu Ibrahim 
Published: December 2015

Abstract
In this work, an approximation method is proposed
for fractional order linear Fredholm type integrodifferential
equations with boundary conditions. The Sinc
collocation method is applied to the examples and its efficiency
and strength is also discussed by some special examples.
The results of the proposed method are compared
to the available analytic solutions.
Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress
Authors: Hodes Georgia E. , Pfau Madeline L. , Purushothaman Immanuel , Ahn H. Francisca , Golden Sam A. , Christoffel Daniel J. , Magida Jane , Brancato Anna , Takahashi Aki , Flanigan Meghan E. , Ménard Caroline , Aleyasin Hossein , Koo Ja Wook , Lorsch Zachary S. , Feng Jian , Heshmati Mitra , Wang Minghui , Turecki Gustavo , Neve Rachel , Zhang Bin , Shen Li , Nestler Eric J. , Russo Scott J. 
Published: December 2015

Depression and anxiety disorders are more prevalent in females, but the majority of research in animal models, the first step in finding new treatments, has focused predominantly on males. Here we report that exposure to subchronic variable stress (SCVS) induces depression-associated behaviors in female mice, whereas males are resilient as they do not develop these behavioral abnormalities. In concert with these different behavioral responses, transcriptional analysis of nucleus accumbens (NAc), a major brain reward region, by use of RNA sequencing (RNA-seq) revealed markedly different patterns of stress regulation of gene expression between the sexes. Among the genes displaying sex differences was DNA methyltransferase 3a (Dnmt3a), which shows a greater induction in females after SCVS. Interestingly, Dnmt3a expression levels were increased in the NAc of depressed humans, an effect seen in both males and females. Local overexpression of Dnmt3a in NAc rendered male mice more susceptible to SCVS, whereasDnmt3aknock-out in this region rendered females more resilient, directly implicating this gene in stress responses. Associated with this enhanced resilience of female mice upon NAc knock-out ofDnmt3awas a partial shift of the NAc female transcriptome toward the male pattern after SCVS. These data indicate that males and females undergo different patterns of transcriptional regulation in response to stress and that a DNA methyltransferase in NAc contributes to sex differences in stress vulnerability.SIGNIFICANCE STATEMENTWomen have a higher incidence of depression than men. However, preclinical models, the first step in developing new diagnostics and therapeutics, have been performed mainly on male subjects. Using a stress-based animal model of depression that causes behavioral effects in females but not males, we demonstrate a sex-specific transcriptional profile in brain reward circuitry. This transcriptional profile can be altered by removal of an epigenetic mechanism, which normally suppresses DNA transcription, creating a hybrid male/female transcriptional pattern. Removal of this epigenetic mechanism also induces behavioral resilience to stress in females. These findings shed new light onto molecular factors controlling sex differences in stress response.
Unbiased, High-Throughput Electron Microscopy Analysis of Experience-Dependent Synaptic Changes in the Neocortex
Authors: Chandrasekaran Santosh , Navlakha Saket , Audette Nicholas J. , McCreary Dylan D. , Suhan Joe , Bar-Joseph Ziv , Barth Alison L. 
Published: December 2015

Neocortical circuits can be altered by sensory and motor experience, with experimental evidence supporting both anatomical and electrophysiological changes in synaptic properties. Previous studies have focused on changes in specific neurons or pathways—for example, the thalamocortical circuitry, layer 4–3 (L4–L3) synapses, or in the apical dendrites of L5 neurons— but a broad-scale analysis of experience-induced changes across the cortical column has been lacking. Without this comprehensive approach, a full understanding of how cortical circuits adapt during learning or altered sensory input will be impossible. Here we adapt an electron microscopy technique that selectively labels synapses, in combination with a machine-learning algorithm for semiautomated synapse detection, to perform an unbiased analysis of developmental and experience-dependent changes in synaptic properties across an entire cortical column in mice. Synapse density and length were compared across development and during whisker-evoked plasticity. Between postnatal days 14 and 18, synapse density significantly increases most in superficial layers, and synapse length increases in L3 and L5B. Removal of all but a single whisker row for 24 h led to an apparent increase in synapse density in L2 and a decrease in L6, and a significant increase in length in L3. Targeted electrophysiological analysis of changes in miniature EPSC and IPSC properties in L2 pyramidal neurons showed that mEPSC frequency nearly doubled in the whisker-spared column, a difference that was highly significant. Together, this analysis shows that data-intensive analysis of column-wide changes in synapse properties can generate specific and testable hypotheses about experience-dependent changes in cortical organization.SIGNIFICANCE STATEMENTDevelopment and sensory experience can change synapse properties in the neocortex. Here we use a semiautomated analysis of electron microscopy images for an unbiased, column-wide analysis of synapse changes. This analysis reveals new loci for synaptic change that can be verified by targeted electrophysiological investigation. This method can be used as a platform for generating new hypotheses about synaptic changes across different brain areas and experimental conditions.