bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possibilities of Immunogenetic Methods in Testing the Activity of Tuberculosis Infection in Children
Authors: Plekhanova M. A. , Klevno N. I. , Gordeeva N. V. , Kalinina O. A. , Ludanny R. I. , Pakhlavonova A. D. 
Published: October 2024

The objective: to test the TREC/KREC DNA levels in children with various manifestations of tuberculosis infection.Subjects and Methods. A prospective, cross-sectional study was conducted in 2022-2024. Observation Group consisted of 115 children aged 6 (5; 7) years, of them 25 were diagnosed with tuberculosis, 63 were diagnosed with latent tuberculosis infection, 27 were not infected with Mycobacterium tuberculosis (conditionally healthy). Results. Findings of the study were as follows: among children with LTBI and a positive response to TRA, only 18.2% had the high TREC DNA concentration which corresponded to the level in the children ill with tuberculosis (t = 0.971; p = 0.342), there was a direct relationship between the TREC DNA and KREC DNA levels in children with LTBI; in 21.2% of children the level was low and indicative of immunodeficiency. If the positive response to TRA persisted in children for two years or more, there was a decrease in the average TREC DNA level, which was statistically significant compared to that in children with TRA+ for less than 2 years. Taking into account the results obtained, the TREC DNA level in children with LTBI can be considered as an additional criterion to assess activity of tuberculosis infection and can be an evidence to justify preventive anti-tuberculosis therapy if studied further. We also found a direct correlation between the TREC and KREC DNA levels in children with LTBI, r = 0.48 (by Spearman). When the positive response to TRA persisted for more than two years, a statistically significant decrease in the TREC DNA level was noted versus the results in children with the first positive response to TRA (t = 2.965; p = 0.005).Conclusion. Taking into account the results obtained, the TREC DNA level in patients with various manifestations of tuberculosis infection can be considered as an additional criterion of infection activity, which will allow differentiated approach to preventive treatment being an important evidence to justify anti-tuberculosis therapy.
Experience of Using Delamanid in the Treatment of Multiple Drug Resistant Tuberculosis
Authors: Bagdasaryan T. R. , Plekhanova M. A. , Smirnov V. Yu. , Grigorieva E. A. , Timakova Yu. I. , Goncharov A. S. 
Published: October 2024

The objective: to evaluate treatment results in MDR TB patients when delamanid is added to the treatment regimen.Subjects and Methods. 91 patients with multiple drug resistant pulmonary tuberculosis were included in the study, of which 36 people (39.6%) were HIV positive. Patients were divided into four comparison groups depending on HIV status and inclusion of delamanid in the treatment regimen. Groups receiving delamanid included only patients in whom bedaquiline or linezolid had been discontinued due to adverse reactions.Results. The results of treatment of MDR TB when delamanid is added to the chemotherapy regimen during the intensive phase, indicate its high effectiveness and safety including HIV positive patients.
“O asfalto embrutece”: Insights sobre estado de fluxo em atividades de ecoturismo e turismo de aventura
Authors: Carneiro Lucas Carregari , Castro Bruno Carneiro , De Faria Gabriel Mendonça , Serafim Maurício Custódio 
Published: October 2024

O artigo tem como objetivo discutir como o fenômeno do estado de fluxo ocorre nas atividades de ecoturismo e turismo de aventura. Marco teórico: Com base numa abordagem pluridimensional do fenômeno turístico, aplicam-se as lentes da psicologia, em especial a teoria do fluxo, para interpretar a experiência dos envolvidos em atividades de ecoturismo e turismo de aventura. Método: Ao todo foram analisadas 292 respostas de uma survey construída para esse fim, referenciada na Técnica do Incidente Crítico (TIC), a qual levanta relatos das melhores e piores experiências nas atividades. Resultados: O artigo contribui com avanços teóricos na aplicação da teoria do fluxo no contexto do ecoturismo e turismo de aventura ao confirmar suas características na amostra. Ele evidencia dois potenciais elementos facilitadores do estado de fluxo que emergiram dos dados: o encontro harmonioso com animais em seu habitat natural e a percepção espiritual da experiência. Além disso, aponta o encontro com resíduos como um fator que pode inibir esse estado. Conclusões: Propõem-se insights e insumos práticos que favorecem a maximização do estado de fluxo no incremento da experiência turística, sendo útil para empresas e organizações baseadas no turismo, assim como profissionais, pesquisadores, professores e estudantes do tema.O artigo tem como objetivo discutir como o fenômeno do estado de fluxo ocorre nas atividades de ecoturismo e turismo de aventura. Marco teórico: Com base numa abordagem pluridimensional do fenômeno turístico, aplicam-se as lentes da psicologia, em especial a teoria do fluxo, para interpretar a experiência dos envolvidos em atividades de ecoturismo e turismo de aventura. Método: Ao todo foram analisadas 292 respostas de uma survey construída para esse fim, referenciada na Técnica do Incidente Crítico (TIC), a qual levanta relatos das melhores e piores experiências nas atividades. Resultados: O artigo contribui com avanços teóricos na aplicação da teoria do fluxo no contexto do ecoturismo e turismo de aventura ao confirmar suas características na amostra. Ele evidencia dois potenciais elementos facilitadores do estado de fluxo que emergiram dos dados: o encontro harmonioso com animais em seu habitat natural e a percepção espiritual da experiência. Além disso, aponta o encontro com resíduos como um fator que pode inibir esse estado. Conclusões: Propõem-se insights e insumos práticos que favorecem a maximização do estado de fluxo no incremento da experiência turística, sendo útil para empresas e organizações baseadas no turismo, assim como profissionais, pesquisadores, professores e estudantes do tema.
KONSEP DASAR MANAJEMEN PENDIDIKAN ISLAM DAN PENERAPANNYA DALAM PENGEMBANGAN MADRASAH
Authors: Nazopah Nada 
Published: October 2024

This paper aims to find out the basic concepts of Islamic education management and its application in madrasah development. This paper is the result of a literature study by collecting data from various literature and information from available sources such as books, journals, reports and other documents. Madrasah development is a process that involves efforts to improve the quality, relevance and effectiveness of Islamic education institutions. Several important steps can be taken in madrasah development, including the preparation of Vision, Mission and Goals, self-evaluation, madrasah development planning, cooperation between stakeholders, and monitoring and evaluation. The implementation of madrasah development can be realized well when the madrasah is able to maximize aspects in the application of management functions, including through planning, good organization, implementation by maximizing finance, human resources, institutions and leadership and control by continuing to evaluate.
Offerings a Reflection of God in the Tradition of the Bonokeling Community in Banyumas Regency, Indonesia
Authors: Rohman Abdul , Suhardi Imam , Noviko Sendy , Huda Ulul , Yamin Muhammad 
Published: October 2024

The purpose of this research are to find out the position of offerings in the Bonokeling community which they do regularly at a predetermined time. This research method uses qualitative descriptive with ethnographic type. Data were collected through observation and interview. Data analysis used interactive method. The result of the research found: 1) The offerings carried out by the Bonokeling community are a reflection of offerings to God and the spirits of their ancestors who are believed to realize safety, peace and prosperity; 2) The dish as an offering to God is an offering that has existed since the time of the prophet Adam, as well as the sacrifice performed by his two sons named Qabil and Habil; 3) God, who is embodied in the ritual of offerings, is included in the realm of the supernatural, the consequence is that human sacrifice and devotion are not offerings in material form, but respect through behavior and inner attitude reflected in the form of intention and sincerity as a taqwa (manifestation of obedience to God). Therefore, offerings buried for ancestral spirits are behaviors and attitudes that are not in accordance with the realm of the supernatural, because spirits in the supernatural realm do not require material offerings, except for human behavior and inner attitudes towards them, such as prayer.
Optimalisasi Sistem Presensi Digital Madrasah Melalui Microsoft Excel Dan Qr Code
Authors: Rofiuddin Rofiuddin  , Indra Maulana  , Faizah Kuratul Aini  
Published: October 2024

Digitalization is not only developing in companies and public school but is also developing in Madrasah schools such as what happened at Madrasah MA Al-Djufri which is located in the Blumbungan, Pamekasan, based on private schools that currently have minimal use of the system. The service here will provide a website combined with Excel and also the application of QR Codes in implementing daily attendance. The existing opportunities must be used as a spark for enthusiasm to improve and innovate so that they can progress and develop. This activity seeks to provide a solution for private madrasas that do not yet have a website. This service through practical work uses a participatory action research approach. Technically, it is carried out through five stages of competition-based service which include preparation, training, mentoring, competition, and appreciation. The real result of this service activity is the existence of a website in the form of a QR code and Excel to support progress at MA Al-Djufri which previously was still not good. As many as 94% of madrasas stated that in general the implementation of community service activities was carried out very well.
Estrategias de intervención para mejorar la calidad de vida de la población vulnerable con secuelas Post Covid-19 en la zona sur de Manabí
Authors: Fuentes Parrales Jocelyne Elizabeth , Miranda Gutierrez Juleydi Stefania , Intriago Andrade Nathaly Katiuska 
Published: October 2024

La calidad de vida es la autopercepción del individuo en función a la satisfacción general, bienestar físico, psicológico y social, actualmente se ha evidenciado individuos que luego de haber superado el COVID-19 presentan secuelas, este contexto afecta la autopercepción de la calidad de vida, unido a sus comorbilidades lo que plantea un nuevo reto para el ministerio de salud pública, el objetivo de esta investigación fue determinar las estrategias de intervención para mejorar la calidad de vida de la población vulnerable con secuelas post COVID-19 en la zona Sur de Manabí. El estudio fue de diseño documental, descriptivo y explicativo, para la recolección de la información se tomó en cuenta artículos científicos originales y bibliográficos de revistas indexadas en PubMed, Scielo, Elsevier, Redalyc, Dialnet, Medigraphic y buscadores como Google académico, sobre el tema planteado. Como resultado principal se destaca que la calidad de vida de aquellas personas que han sido infectadas por el coronavirus puede presentar daño en su estado mental padeciendo ansiedad y depresión, el insomnio suele ser parte de la vida cotidiana. Se concluyo que las afectaciones dentro del sector salud han dejado resultados inciertos con el paso del tiempo, el aumento de los sobrevivientes a esta nueva afección ha hecho que tras la recuperación se mantenga cierto desconocimiento sobre las secuelas que se manifiestan después del alta hospitalaria y su calidad de vida. El articulo permitirá la aplicación de conocimientos en asignaturas como inmunología, bioquímica y salud pública articulando de esta manera al proyecto de investigación titulado “Identificación y seguimiento de secuelas post-COVID-19 e intervención en poblaciones vulnerables de la zona Sur de Manabí.”, conjunto con el proyecto de vinculación denominado "Estrategias de intervención en poblaciones vulnerables identificadas con secuelas post COVID-19 de la Zona Sur de Manabí. Fase I".
CONTRIBUIÇÕES DA ALIMENTAÇÃO FUNCIONAL NO TRATAMENTO DIETOTERAPICO EM PACIENTES COM DIABETES MELLITUS 2
Authors:   Francisca Marta Nascimento de Oliveira Freitas, Maciel Daniele da Costa ,   Rosimar Honorato Lobo
Published: October 2024

Type 2 diabetes mellitus is a chronic metabolic condition that affects millions of people worldwide. In this context, the importance of a proper diet is crucial for managing this disease. The main objective of this research was to analyze the importance of functional foods in the management of type 2 diabetes, focusing on how these foods can contribute to glycemic control and improve the quality of life for patients. The research was conducted through a literature review covering the period from 2014 to 2024. The consulted databases included Scielo, Google Scholar, and Lilacs, analyzing recent studies on the effects of functional foods on type 2 diabetes, focusing on their bioactive compounds. The findings indicate that many functional foods possess properties that help modulate the glycemic response, as well as reduce the risk of complications associated with diabetes. Including these foods in the diet can promote healthier eating habits. The results of this research highlight the importance of functional foods as a valuable strategy in treating type 2 diabetes mellitus. These foods not only help control blood glucose levels but also contribute to preventing complications associated with the disease. Integrating functional foods into patients' daily diets can significantly improve their metabolic health and quality of life.
ISTA – uma narração de transições
Authors: Varley Julia 
Published: October 2024

Neste artigo, Julia Varley, atriz do Odin Teatret, narra a história da ISTA - International School of Theatre Anthropology (Escola Internacional de Antropologia Teatral), desde a primeira seção — que aconteceu no ano de 1980, em Bonn, Alemanha —, até a décimaquinta seção — ocorrida em 2016, em Albino, Itália. Este escrito é originalmente endereçado aos participantes da décima-quarta seção — que teve lugar em 2005, em Wroclaw e na vila de Krzyozowa, Polônia — e foi retrabalhado para a décima-quinta ISTA. No texto, a ISTA é retratada como um ambiente de diversidade profissional, onde artistas e pesquisadores se reúnem ao redor de tarefas concretas. Sua história é narrada como uma contínua sucessão de transições e transformações que permitiram que a inquietação profissional e a obstinação da pesquisa permanecessem vivas ao longo dos anos.
A Sabotagem do Movimento, de Hijikata Tatsumi, e o desejo de matar a ideologia da morte
Authors: Centonze Katja 
Published: October 2024

Morte e desejo aparecem como características essenciais no butô de Hijikata Tatsumi, o que traz em pauta o paradoxo da vida e da morte, da quietude e do movimento. Hijikata coloca essas contradições nas raízes da dança em si. Esta análise aponta vários aspectos encontrados na estética da morte e nos processos de execução do butô, que captam a tensão entre estar morto e/ou vivo, entre presença e ausência. Mostra-se como os estados físicos da morte biológica são encenados, e demonstra-se que, no teatro não humano do erotismo de Hijikata, a morte se destaca como um objeto colocado com outros objetos no palco, incluindo o corpo carnal (nikutai) do performer. A discussão foca na investigação radical de corporalidade, de Hijikata, que coloca sob crítica não apenas o nikutai, mas até mesmo o cadáver (shitai), revelando as narrativas culturais às quais estão sujeitos.
Gentilmente cedido pela autora e originalmente publicado em inglês na obra Ca’ Foscari Japanese Studies 6 - Morte e Desejo no Japão Contemporâneo: Representação, Prática, Performance. Editado por Andrea De Antoni e Massimo Raveri, 2017. ISBN [ebook] 978-88-6969-151-5 | ISBN [print] 978-88-6969-150-8. Disponível em: https://edizionicafoscari.unive.it/media/pdf/books/978-88-6969-150-8/978-88-6969-150-8.pdf
Inquietações do corpo de carne de Hijikata Tatsumi
Authors: Picarelli Caio 
Published: October 2024

O presente artigo se debruça sobre as reflexões poéticas do “corpo de carne”, inquietação do bailarino, diretor e fundador da dança butô, Hijikata Tatsumi. O objetivo principal é discutir este conceito em oposição às construções opressivas do que pode ser chamado de “corpo social” que Hijikata visava destruir através de suas inovadoras proposições em dança.
O que sustenta o Rio
Authors: Cristina da Silva Sousa Marcia , Rios Joelington 
Published: October 2024

Fotos de Joelington Rios com entrevista de Marcia Sousa.
Diagramação de Deyla Dayanne Rabelo Silva.*Joelington Rios é o autor da Foto que ilustra a capa deste número 6, da Ephemera.
Characterizing Fatigue by Multiple Sclerosis Subtype and Determining Validity of a Fatigue Scale Specific to Persons With Progressive Multiple Sclerosis
Authors: Feldpausch Jennie , Plummer Prudence , Abou-Rass Zade , Fritz Nora 
Published: October 2024

ABSTRACT

BACKGROUND:
Fatigue is a common and debilitating symptom of multiple sclerosis (MS). Prior work suggests that the prevalence of fatigue is higher in progressive MS (PMS) than relapsing MS (RRMS). No patient-reported outcomes of fatigue have been validated specifically for individuals with PMS, despite evidence that they characterize fatigue differently than individuals with RRMS. Therefore, the objective of this study was to characterize fatigue in both the RRMS and PMS subtypes and determine the convergent validity of the Fatigue Symptoms and Impacts Questionnaire (FSIQ) for individuals with PMS.

METHODS:
A nationwide survey yielded 806 (637 RRMS, 169 PMS) complete responses. The survey collected demographic information and self-reported disease severity, as well as measures of fatigue, health-related quality of life, and self-reported functioning.

RESULTS:
People with PMS reported significantly more severe fatigue than those with RRMS (P &lt; .001). The FSIQ subdomains of physical, cognitive/emotional, and coping demonstrated moderate (r = 0.5-0.75) to excellent (r &gt; 0.75) validity (P &lt; .001) with other measures of fatigue.

CONCLUSIONS:
More severe fatigue in people with PMS as compared to those with RRMS underscores the importance of using validated tools to capture fatigue in persons with PMS. The FSIQ is a valid and freely available tool to capture the physical, mental, and emotional fatigue of individuals with PMS.
Evaluation of shaping ability, apical transportation and centering ratio of T-Endo Must, WaveOne Gold, and Trunatomy in resin blocks
Authors: Karaca Sakallı Aybüke , Ekici Mügem Aslı 
Published: October 2024

Purpose
This study aimed to compare the shaping abilities of different nickel-titanium file systems.

Materials and Methods
Sixty-six j-shaped resin blocks were randomly divided into three groups (n = 22): Group T-Endo MUST (TE), Group WaveOne (W), Group TruNatomy (TR). After canal preparation, the amount of material removed from the canal, the centering ratio of the file systems, the direction and amount of canal transportation, and shaping errors were evaluated. Shaping time was calculated. Data of shaping time were analyzed with ANOVA and Tamhane test. Data on the shaping ability were analyzed with two- and three-way ROBUST ANOVA. The significance level was set at p = 0.05.

Results
There was a statistically significant difference between all groups for shaping time (p < 0.001). There was a statistically significant difference between groups for the total amount of material removed (p < 0.001). The directions of canal transportation were the inner surface of the curvature for W and TR and the outer for TE. There was no statistically significant difference between the groups for the amount of transportation (p > 0.05). The centering ratio of TE and W was statistically higher than TruNatomy (p < 0.001).

Conclusions
TruNatomy removed the least material that supported the minimally invasive endodontic approach. All file systems caused similar transportation and did not change the original canal shape.
Characterization of the complete mitochondrial genome of the Sunda stink-badger (Mydaus javanensis) from the island of Borneo
Authors: Subbiah Vijay Kumar , Gomez Chrishen Robert , Robben Dexter Miller , Subramaniam Ranjita , Hearn Andrew James 
Published: October 2024

Background
The Mephitidae is a family of skunks and stink-badgers that includes 12 extant species in four genera, namely, Mydaus, Conepatus, Mephitis and Spilogale. Mydaus is the only genus within Mephitidae found outside the American continent, with its distribution limited to the islands of Borneo, Indonesia and Philippines. There are two extant species of Mydaus i.e., javanensis and marchei. Currently, complete mitogenomes are unavailable for either species. Here, we present the characterization of the first complete mitogenome for the Sunda stink-badger (Mydaus javanensis) from the island of Borneo.

Methods
Muscle tissue was obtained and the DNA was sequenced using a combination of Illumina Barcode Tagged Sequence (BTSeq) and Sanger sequencing techniques. The genome was annotated with MITOS and manually checked for accuracy. A circular map of the mitogenome was constructed with Proksee. Relative synonymous codon usage (RSCU) and codon frequency were calculated using MEGA-X. The protein coding genes (PCGs) were aligned with reference sequences from GenBank and used for the construction of phylogenetic trees (maximum liklihood (ML) and Bayesian inference (BI)). Additionally, due to the lack of available complete genomes in public databases, we constructed another tree with the cyt b gene.

Results
The complete circular mitogenome was 16,391 base pairs in length. It comprises the typical 13 protein-coding genes, 22 tRNAs, two ribosomal RNA genes, one control region (CR) and an L-strand replication origin (OL). The G+C content was 38.1% with a clear bias towards A and T nucleotides. Of the 13 PGCs, only ND6 was positioned in the reverse direction, along with five other tRNAs. Five PCGs had incomplete stop codons and rely on post-transcriptional polyadenylation (TAA) for termination. Based on the codon count, Leucine was the most common amino acid (589), followed by Threonine (332) and Isoleucine (325). The ML and BI phylogenetic trees, based on concatenated PCGs and the cyt b gene, respectively, correctly clustered the species with other members of the Mephitidae family but were unique enough to set it apart from Conepatus, Mephitis and Spilogale. The results confirm Mydaus as a member of the mephitids and the mitogenome will be useful for evolutionary analysis and conservation of the species.