bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial prediction modulates the rhythm of attentional sampling
Authors: Huang Yih-Ning , Liang Wei-Kuang , Juan Chi-Hung 
Published: September 2024

Abstract
Recent studies demonstrate that behavioral performance during visual spatial attention fluctuates at theta (4 to 8 Hz) and alpha (8 to 16 Hz) frequencies, linked to phase–amplitude coupling of neural oscillations within the visual and attentional system depending on task demands. To investigate the influence of prior spatial prediction, we employed an adaptive discrimination task with variable cue–target onset asynchronies (300 to 1,300 ms) and different cue validity (100% & 50%). We recorded electroencephalography concurrently and adopted adaptive electroencephalography data analytical methods, namely, Holo–Holo-Hilbert spectral analysis and Holo–Hilbert cross-frequency phase clustering. Our findings indicate that response precision for near-threshold Landolt rings fluctuates at the theta band (4 Hz) under certain predictions and at alpha & beta bands (15 & 19 Hz) with uncertain predictions. Furthermore, spatial prediction strengthens theta–alpha modulations at parietal-occipital areas, frontal theta/parietal-occipital alpha phase–amplitude coupling, and within frontal theta-alpha phase–amplitude coupling. Notably, during the pretarget period, beta-modulated gamma oscillations in parietal-occipital areas predict response precision under uncertain prediction, while frontal theta/parietal-occipital alpha phase–amplitude coupling predicts response precision in spatially certain conditions. In conclusion, our study highlights the critical role of spatial prediction in attentional sampling rhythms with both behavioral and electroencephalography evidence.
The Intestinal Mucin Isoform Landscape Reveals Region-Specific Biomarker Panels for Inflammatory Bowel Disease Patient Stratification
Authors: Arras Wout , Breugelmans Tom , Oosterlinck Baptiste , De Man Joris G , Malhotra-Kumar Surbhi , Abrams Steven , Van Laere Steven , Macken Elisabeth , Somers Michaël , Jauregui-Amezaga Aranzazu , De Winter Benedicte Y , Smet Annemieke 
Published: September 2024

Abstract

Background and aims
Mucosal healing is considered a key therapeutic endpoint in inflammatory bowel diseases (IBD) and comprises endoscopic improvement of inflammation without taking barrier healing into account. Mucins are critical components of the mucosal barrier function that give rise to structurally diverse isoforms. Unraveling disease-associated mucin isoforms that could act as an indication for barrier function would greatly enhance IBD management.

Methods
We present the intestinal mucin RNA isoform landscape in IBD and control patients using a targeted mucin isoform sequencing approach on a discovery cohort (n = 106). Random Forest modeling (n = 1683 samples) with external validation (n = 130 samples) identified unique mucin RNA isoform panels that accurately stratified IBD patients in multiple subpopulations based on inflammation, IBD subtype (Crohn’s disease [CD], ulcerative colitis [UC]), and anatomical location of the intestinal tract (i.e. ileum, proximal colon, distal colon, and rectum).

Results
Particularly, the mucin RNA isoform panels obtained from the inflamed UC and CD distal colon showed high performance in distinguishing inflamed biopsies from their control counterparts (AUC of 93.3% and 91.1% in the training, 95.0% and 96.0% in the test, and 89.5% and 78.3% in the external validation datasets, respectively). Furthermore, the differentially expressed MUC4 (PB.1238.363), MUC5AC (PB.2811.15), MUC16 (ENST00000397910.8), and MUC1 (ENST00000462317.5 and ENST00000620103.4) RNA isoforms frequently occurred throughout the different panels highlighting their role in IBD pathogenesis.

Conclusions
We unveiled region-specific mucin RNA isoform panels capturing the heterogeneity of the IBD patient population and showing great potential to indicate barrier function in IBD patients.
Health-related quality of life with rivaroxaban plus aspirin vs. aspirin alone in chronic stable cardiovascular disease: Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial
Authors: Xie Feng , Yan Jiajun , Eikelboom John , Anand Sonia , Muehlhofer Eva , Pullenayegum Eleanor , Wang Yang , Avezum Alvaro , Bhatt Deepak L , Yusuf Salim , Bosch Jackie 
Published: September 2024

Abstract

Aims
This study aimed to compare the effects of the combination of rivaroxaban and aspirin with aspirin alone on health-related quality of life in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial.

Methods and results
Health-related quality of life assessed using the EQ-5D-3L. The treatment effects on health utility and EQ visual analogue scale (EQ VAS) scores were compared between rivaroxaban plus aspirin and aspirin alone in terms of adjusted mean difference in change from baseline and odds ratio of having deterioration events. Nine thousand forty-nine (98.9%) and 6916 (75.5%) completed the EQ-5D-3L at baseline and at final visit, respectively. Nine thousand twenty-eight (98.9%) and 6887 (76.3%) completed the EQ-5D-3L at baseline and final visit, respectively. Mean (standard deviation) health utility and EQ VAS scores at baseline were 0.871 (0.141) and 76.0 (15.3), respectively, for the rivaroxaban plus aspirin group, compared with 0.873 (0.139) and 75.8 (15.1) for the aspirin group. Adjusted mean difference in change from baseline utility was −0.002 [95% confidence interval (CI), −0.006, 0.002, P = 0.30] between the combination therapy group and the aspirin group. The odds ratio (95% CI) of experiencing deterioration in health utility was 1.01 (95% CI, 0.93, 1.10, P = 0.81) between the two groups. Adjusted mean difference in change from baseline EQ VAS was 0.02 (95% CI, −0.43, 0.47, P = 0.93) between the two groups.

Conclusion
This analysis of the COMPASS trial demonstrated that the quality of life of patients was similar between the rivaroxaban plus aspirin group and the aspirin alone group.

Registration
Trial registration number: ClinicalTrials.gov number (NCT01776424). Trial protocol and statistical analysis plan: https://www.nejm.org/doi/full/10.1056/NEJMoa1709118#APPNEJMoa1709118PRO.
How do Workers Adjust to Robots? Evidence from China
Authors: Giuntella Osea , Lu Yi , Wang Tianyi 
Published: September 2024

Abstract
We analyse the effects of exposure to industrial robots on labour market adjustments, exploring longitudinal household data from China. We find that a one-standard-deviation increase in robot exposure led to a decline in labour force participation (−1%), employment (−7%) and hourly earnings (−8%) of Chinese workers. At the same time, among those who kept working, robot exposure increased the number of hours worked by 8%. These effects were concentrated among the less educated and larger among male, prime-age and older workers. We also find that more exposed workers increased their participation in technical training and were significantly more likely to retire earlier.
Bipolar radiofrequency ablation of refractory ventricular arrhythmias: results from a multicentre network
Authors: Futyma Piotr , Sultan Arian , Zarębski Łukasz , Imnadze Guram , Maslova Vera , Bordignon Stefano , Kousta Maria , Knecht Sven , Pavlović Nikola , Peichl Petr , Lian Evgeny , Kueffer Thomas , Scherr Daniel , Pfeffer Michael , Moskal Paweł , Cismaru Gabriel , Antolič Bor , Wałek Paweł , Chen Shaojie , Martinek Martin , Kollias Georgios , Derndorfer Michael , Seidl Sebastian , Schmidt Boris , Lüker Jakob , Steven Daniel , Sommer Philipp , Jastrzębski Marek , Kautzner Josef , Reichlin Tobias , Sticherling Christian , Pürerfellner Helmut , Enriquez Andres , Wörmann Jonas , Chun Julian K R 
Published: September 2024

Abstract

Aims
Advanced ablation strategies are needed to treat ventricular tachycardia (VT) and premature ventricular complexes (PVC) refractory to standard unipolar radiofrequency ablation (Uni-RFA). Bipolar radiofrequency catheter ablation (Bi-RFA) has emerged as a treatment option for refractory VT and PVC. Multicentre registry data on the use of Bi-RFA in the setting of refractory VT and PVC are lacking. The aim of this Bi-RFA registry is to determine its real-world safety, feasibility, and efficacy in patients with refractory VT/PVC.

Methods and results
Consecutive patients undergoing Bi-RFA at 16 European centres for recurring VT/PVC after at least one standard Uni-RFA were included. Second ablation catheter was used instead of a dispersive patch and was positioned at the opposite site of the ablation target. Between March 2021 and August 2024, 91 patients underwent 94 Bi-RFA procedures (74 males, age 62 ± 13, and prior Uni-RFA range 1–8). Indications were recurrence of PVC (n = 56), VT (n = 20), electrical storm (n = 13), or PVC-triggered ventricular fibrillation (n = 2). Procedural time was 160 ± 73 min, Bi-RFA time 426 ± 286 s, and mean Uni-RFA time 819 ± 697 s. Elimination of clinical VT/PVC was achieved in 67 (74%) patients and suppression of VT/PVC in a further 10 (11%) patients. In the remaining 14 patients (15%), no effect on VT/PVC was observed. Three major complications occurred: coronary artery occlusion, atrioventricular block, and arteriovenous fistula. Follow-up lasted 7 ± 8 months. Nineteen patients (61%) remained VT free. ≥80% PVC burden reduction was achieved in 45 (78%).

Conclusion
These real-world registry data indicate that Bi-RFA appears safe, is feasible, and is effective in the majority of patients with VT/PVC.
Pollution gradients shape microbial communities associated with Ae. albopictus larval habitats in urban community gardens
Authors: Duval Penelope , Martin Edwige , Vallon Laurent , Antonelli Pierre , Girard Maxime , Signoret Aymeric , Luis Patricia , Abrouk Danis , Wiest Laure , Fildier Aurélie , Bonnefoy Christelle , Jame Patrick , Bonjour Erik , Cantarel Amelie , Gervaix Jonathan , Vulliet Emmanuelle , Cazabet Rémy , Minard Guillaume , Valiente Moro Claire 
Published: September 2024

Abstract
The Asian tiger mosquito Aedes albopictus is well adapted to urban environments and takes advantage of the artificial containers that proliferate in anthropized landscapes. Little is known about the physicochemical, pollutant, and microbiota compositions of Ae. albopictus-colonized aquatic habitats and whether these properties differ with noncolonized habitats. We specifically addressed this question in French community gardens by investigating whether pollution gradients (characterized either by water physicochemical properties combined with pollution variables or by the presence of organic molecules in water) influence water microbial composition and then the presence/absence of Ae. albopictus mosquitoes. Interestingly, we showed that the physicochemical and microbial compositions of noncolonized and colonized waters did not significantly differ, with the exception of N2O and CH4 concentrations, which were higher in noncolonized water samples. Moreover, the microbial composition of larval habitats covaried differentially along the pollution gradients according to colonization status. This study opens new avenues on the impact of pollution on mosquito habitats in urban areas and raises questions on the influence of biotic and abiotic interactions on adult life-history traits and their ability to transmit pathogens to humans.
Unveiling the Virome of Wild Birds: Exploring CRESS-DNA Viral Dark Matter
Authors: Dai Ziyuan , Wang Haoning , Xu Juan , Lu Xiang , Ni Ping , Yang Shixing , Shen Quan , Wang Xiaochun , Li Wang , Wang Xiaolong , Zhou Chenglin , Zhang Wen , Shan Tongling 
Published: September 2024

Abstract
Amid global health concerns and the constant threat of zoonotic diseases, this study delves into the diversity of circular replicase-encoding single-stranded DNA (CRESS-DNA) viruses within Chinese wild bird populations. Employing viral metagenomics to tackle the challenge of “viral dark matter,” the research collected and analyzed 3,404 cloacal swab specimens across 26 bird families. Metagenomic analysis uncovered a rich viral landscape, with 67.48% of reads classified as viral dark matter, spanning multiple taxonomic levels. Notably, certain viral families exhibited host-specific abundance patterns, with Galliformes displaying the highest diversity. Diversity analysis categorized samples into distinct groups, revealing significant differences in viral community structure, particularly noting higher diversity in terrestrial birds compared to songbirds and unique diversity in migratory birds versus perching birds. The identification of ten novel Circoviridae viruses, seven Smacoviridae viruses, and 167 Genomoviridae viruses, along with 100 unclassified CRESS-DNA viruses, underscores the expansion of knowledge on avian-associated circular DNA viruses. Phylogenetic and structural analyses of Rep proteins offered insights into evolutionary relationships and potential functional variations among CRESS-DNA viruses. In conclusion, this study significantly enhances our understanding of the avian virome, shedding light on the intricate relationships between viral communities and host characteristics in Chinese wild bird populations. The diverse array of CRESS-DNA viruses discovered opens avenues for future research into viral evolution, spread factors, and potential ecosystem impacts.
Confidants and Caregivers: Network Multiplexity and Subjective Well-Being of Older Adults
Authors: Shang Yongxin , Patterson Sarah E 
Published: September 2024

Abstract

Objectives
Older adults rely on personal networks for different types of support. Given shifts in family composition in later adulthood, more work is needed to map network members who can provide multiple aspects of support and the implications for older adults. We explore the phenomenon of having the same network members as both a confidant and a caregiver (multiplexity) and its implications for the well-being of older adults.

Methods
Using the 2011 National Health and Aging Trends Study, we describe the prevalence of having someone as both a confidant and a caregiver (henceforth “multiplex helper”) for older adults and examine its association with subjective well-being. We also investigate the differences by having whom as multiplex helpers.

Results
About three-quarters (76%) of older adults with at least 1 confidant and 1 caregiver have at least 1 multiplex helper. Partnered older adults are more likely to have any multiplex helpers than unpartnered counterparts and usually nominate their partner as a multiplex helper, whereas the unpartnered are more likely to rely on their children to serve multiple roles, especially for widowed older adults. Having a multiplex helper is associated with better subjective well-being.

Discussion
Network multiplexity is prevalent and positively associated with the subjective well-being of older adults who have at least 1 confidant and 1 caregiver, above and beyond having any confidants or caregivers separately. The baseline patterns established in this study lay the groundwork for future research to further explore support dynamics in older adults’ networks.
Characteristics of people with type 1 diabetes influence the educational process for starting insulin pump therapy: an observational study
Authors: Izquierdo Verónica , Pazos-Couselo Marcos , González-Rodríguez María , Martínez-Santos Alba-Elena , Andujar-Plata Paula , Díaz-Trastoy Olaia , Fernández-Pombo Antía , Sigüeiro-Paulos Sara , Rodríguez-González Raquel 
Published: September 2024

Abstract
Limited data exist on educational programs for people using insulin pump (IP) therapy or those considering its initiation, and the influence of individual characteristics on their educational pathway remains unclear. Our aim was to analyze the characteristics of people with type 1 diabetes (T1D) referred for IP therapy and how these characteristics may influence their educational process. A retrospective descriptive observational study was carried out on people with T1D referred for participation in a structured pre-IP educational program in a hospital setting. Educational, sociodemographic and clinical variables were collected and analyzed. Participants were followed up 5 years after IP placement. Seventy-one people finalized the educational program, of whom 10 experienced major barriers to completing it. People with lower educational level required more sessions and weeks to complete it compared to those with higher educational levels. People referred due to suboptimal metabolic control and hypoglycemia also required more time to complete the process. It is essential for diabetes educators to recognize the diversity of characteristics, needs and challenges among the participants in an educational program. Based on this, they must adapt strategies to provide more effective, person-centered diabetes education and support, fostering positive and sustained outcomes and engagement for participants.
Predictors of Pandemic Impact in a Rural Community: Survey Results from a Community Partnership to Support Health and Well-Being
Authors: Yates Helen T , Lee Spencer Elise , Toothman Megan 
Published: September 2024

Abstract
Rural communities have struggled to fight the COVID-19 pandemic. Despite slower spread at the start of the pandemic in these areas, by 2021, they experienced higher death and hospitalization rates compared with urban areas. Increased mental health issues including stress, depression, and anxiety were also reported in rural areas following the start of the pandemic. Young people in these communities were significantly impacted by COVID-19, reporting increased stress and mental health issues. To examine the effects of COVID-19 on these local rural communities, authors conducted a survey in coordination with their community partners. The survey was completed by 119 participants across three rural counties and included 69 questions from the Pandemic Stress Index and the World Health Organization COVID-19 Rapid Quantitative Assessment Tool. Authors’ results indicated that age, depression, and anxiety were predictors of higher self-reported COVID-19 impact. The strongest predictor of high pandemic impact in the sample was the combination of depression and anxiety symptoms. Authors used these results to inform their partners about the need for increased mental health services that are tailored for young adults in their communities. More research is needed to determine which services will be most beneficial and how to best reach those in need. Social workers in both public health and mental health settings are poised to help.
Natural history of autologous sperm cryostorage
Authors: Sleiman S , Bacha F , Di Pierro I , Idan A , Savkovic S , Muir C A , Zhang T , Jayadev V , Conway A J , Handelsman D J 
Published: September 2024

Abstract

STUDY QUESTION
What is the natural history of elective autologous sperm cryostorage prior to gonadotoxic treatment?

SUMMARY ANSWER
We estimate large sample median times to transfer for use, to the man’s death or to discard of sperm, and their determinants, as the key operational outcomes of sperm cryostorage.

WHAT IS KNOWN ALREADY
No large sample studies of the natural history of sperm cryostorage prior to gonadotoxic treatment are reported.

STUDY DESIGN, SIZE, DURATION
This observational single-centre study covered 45 years of outcomes with a survival analysis for sperm cryostorage prior to scheduled gonadotoxic treatment, and its determinants.

PARTICIPANTS/MATERIALS, SETTING, METHODS
This study included 3923 men (mean age 30 years) who sought sperm cryostorage for a wide range of cancers and other diseases requiring gonadotoxic treatments.

MAIN RESULTS AND THE ROLE OF CHANCE
The median time to transfer for use (n = 371 men 9%) was 2.4 years (quartiles 1.0, 6.0), the median time to death (n = 553 men, 14%) was 1.7 (0.9, 3.3) years, and the median time to discard (n = 1807 men, 46%) was 7.7 (1.7, 11.1) years. In multivariate Cox model regression, the underlying disease, number of storage visits and follow-up visits, and whether sperm were seen at follow-up visits were consistent predictors of times to outcomes.

LIMITATIONS, REASONS FOR CAUTION
This study did not investigate sperm cryostorage for reasons other than gonadotoxic treatment, nor the fertilization outcomes of the cryostored sperm.

WIDER IMPLICATIONS OF THE FINDINGS
These data provide estimates of the key operational factors for sperm cryostorage programs, prior to potentially sterilizing gonadotoxic treatments, and free from financial or insurance restrictions.

STUDY FUNDING/COMPETING INTEREST(S)
There was no specific funding for this study. D.J.H. has provided expert witness testimony to antidoping and professional standards tribunals and is supported by an NHMRC Investigator Grant. The other authors have no disclosures.

TRIAL REGISTRATION NUMBER
N/A.
Twin long short-term memory for environmental hierarchical planning of low-carbon landscape architecture
Authors: Ren Lizhuo , Xu Ning 
Published: September 2024

Abstract
In light of the pressing need to mitigate carbon emissions and safeguard the environment, the imperative of imbuing landscape planning with low-carbon principles has taken center stage. This investigative endeavor embarks on a pioneering trajectory by presenting a groundbreaking methodology for low-carbon landscape planning, employing the twin long short-term memory (LSTM) model. This innovative approach endeavors to seamlessly amalgamate urban landscape development with low-carbon practices. Initially, we lay the foundation by introducing an all-encompassing big data framework, which serves as the bedrock for processing historical environmental data within the landscape planning domain. Subsequently, we advocate for the adoption of the twin LSTM model, which proficiently anticipates the dynamic trajectories of low-carbon environments. Moreover, we ascertain that the optimization of feature correlations in the planning process culminates in the formulation of bespoke strategies tailored to low-carbon planning. The empirical evidence substantiates the superiority of our approach, surpassing analogous algorithms in both performance and scope. Furthermore, our holistic methodology diligently accounts for the far-reaching ramifications of socio-economic factors, ecological considerations, and cultural landscapes. This comprehensive vantage point augments the efficacy and durability of planning initiatives, thereby diligently shepherding the trajectory of urban landscapes towards a realm characterized by low-carbon practices and sustainable environmental construction.