bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global value chain and its impact on the linkage between exchange rate and export: Cases of China, Japan and Korea
Authors: Bang Hokyung , Park Misook 
Published: December 2017

AbstractThe link between exchange rate and trade has been studied for a long time, but there is no consensus about their relation. This paper tests the old argument, whether depreciation of real effective exchange rates (REERs) raises exports. We differentiate the test with earlier studies by employing a new measurement of REER and incorporating the effect of GVCs. We measured REER at industry level with value‐added trade weights. We analysed the topic with LSDV and system GMM for China, Japan and Korea since these counties are known to participate actively in GVCs. Our main finding is that exchange rate has significant impact on trade for three countries. However, the movement of elasticity of export to REER varies by country. While the elasticity in China decreased over time, Korea and Japan experienced increasing patterns between mid‐1990s and mid‐2000s and decreasing trends afterwards. This study also tests whether the level of incorporation in GVCs causes a change in elasticity. The results show that growing participation in GVCs lowers the elasticity of export to REER in absolute value. However, this result is only statistically significant in Korea.
Impact of high‐intensity interval training and moderate‐intensity continuous training on resting and postexercise cardiac troponin T concentration
Authors: Nie Jinlei , Zhang Haifeng , Kong Zhaowei , George Keith , Little Jonathan P. , Tong Tomas K. , Li Feifei , Shi Qingde 
Published: December 2017

New Findings
What is the central question of this study?
Does exercise training impact resting and postexercise cardiac troponin T (cTnT) concentration?

What is the main finding and its importance?
This randomized controlled intervention study demonstrated that 12 weeks of either high‐intensity interval training or moderate‐intensity continuous training largely abolished the exercise‐induced elevation in cTnT when exercise was performed at the same absolute intensity. There was no impact of training on resting cTnT or postexercise appearance of cTnT when exercise was performed at the same relative intensity. These findings provide new information that might help clinicians with decision‐making in relationship to basal and postexercise values of cTnT in individuals with different training status.

AbstractWe evaluated the influence of 12 weeks of high‐intensity interval training [HIIT; repeated 4 min cycling at 90% of maximal oxygen uptake () interspersed with 3 min rest, 200–300 kJ per session, 3 or 4 days each week] and work‐equivalent moderate‐intensity continuous training (MICT; continuous cycling at 60% ) on resting cardiac troponin T (cTnT) and the appearance of exercise‐induced cTnT. Forty‐eight sedentary obese young women were randomly assigned to HIIT, MICT or a control group. The and body composition were measured before and after training. At baseline, cTnT was assessed using a high‐sensitivity assay at rest and immediately, 2 and 4 h after 45 min cycling at 60% . After a 12 week training period, cTnT was assessed before and after 45 min cycling at the same relative and absolute intensities as before training. Training led to higher and lower fat mass in both HIIT and MICT groups (all P < 0.05). Before training, cTnT was significantly elevated in all three groups (by 35–118%, all P < 0.05) with acute exercise. After training, both resting and postexercise cTnT concentrations (same relative intensity) were similar to pretraining values. In contrast, postexercise cTnT (same absolute intensity, which represented a smaller exercise stimulus) was not elevated from rest in both HIIT and MICT groups. In conclusion, 12 weeks of either HIIT or MICT largely abolished the postexercise elevation of cTnT concentration when exercise was performed at the same absolute intensity. There was, however, no impact of training on resting cTnT or postexercise appearance of cTnT for exercise performed at the same relative intensity.
An integrated tool for determining the primary origin site of metastatic tumours
Authors: Santos Marcos Tadeu dos , Souza Bruno Feres de , Cárcano Flavio Mavignier , Vidal Ramon de Oliveira , Scapulatempo-Neto Cristovam , Viana Cristiano Ribeiro , Carvalho Andre Lopes 
Published: December 2017

AimsCancers of unknown primary sites account for 3%–5% of all malignant neoplasms. Current diagnostic workflows based on immunohistochemistry and imaging tests have low accuracy and are highly subjective. We aim to develop and validate a gene-expression classifier to identify potential primary sites for metastatic cancers more accurately.MethodsWe built the largest Reference Database (RefDB) reported to date, composed of microarray data from 4429 known tumour samples obtained from 100 different sources and divided into 25 cancer superclasses formed by 58 cancer subclass. Based on specific profiles generated by 95 genes, we developed a gene-expression classifier which was first trained and tested by a cross-validation. Then, we performed a double-blinded retrospective validation study using a real-time PCR-based assay on a set of 105 metastatic formalin-fixed, paraffin-embedded (FFPE) samples. A histopathological review performed by two independent pathologists served as a reference diagnosis.ResultsThe gene-expression classifier correctly identified, by a cross-validation, 86.6% of the expected cancer superclasses of 4429 samples from the RefDB, with a specificity of 99.43%. Next, the performance of the algorithm for classifying the validation set of metastatic FFPE samples was 83.81%, with 99.04% specificity. The overall reproducibility of our gene-expression-classifier system was 97.22% of precision, with a coefficient of variation for inter-assays and intra-assays and intra-lots <4.1%.ConclusionWe developed a complete integrated workflow for the classification of metastatic tumour samples which may help on tumour primary site definition.
A BET Bromodomain Inhibitor Suppresses Adiposity-Associated Malignant Transformation
Authors: Chakraborty Debrup , Benham Vanessa , Jdanov Vladislav , Bullard Blair , Leal Ana S. , Liby Karen T. , Bernard Jamie J. 
Published: December 2017

Abstract
Almost half a million of all new cancers have been attributed to obesity and epidemiologic evidence implicates visceral adipose tissue (VAT) and high-fat diets (HFD) in increasing cancer risk. We demonstrated that VAT-derived fibroblast growth factor 2 (FGF2) from mice fed an HFD or obese individuals stimulates the malignant transformation of epithelial cells. Mechanism-based strategies to prevent this VAT-enhanced tumorigenesis have not been explored. Clinical studies have indicated that bromodomain inhibitors have considerable potential as therapeutic agents for cancer by inhibiting the activity of several oncogenes, including c-Myc; however, their chemopreventive activity is unknown. We show herein that mice with visceral adiposity have elevated nuclear c-Myc expression in their epidermis. We hypothesized that the bromodomain inhibitor I-BET-762 (I-BET) would have efficacy in the prevention of malignant transformation by VAT and FGF2. We tested this hypothesis using our novel models of VAT-stimulated transformation in vitro and FGF2- stimulated tumor formation in vivo. We found that I-BET significantly attenuates VAT and FGF2-stimulated transformation and inhibits VAT-induced c-Myc protein expression in several skin and breast epithelial cell lines. Moreover, I-BET attenuated tumor growth significantly in FGF2-treated nude mice. Work is ongoing to determine the role of visceral adiposity in c-Myc activity in several tissues and determine the inhibitory effect of I-BET on VAT-promoted tumors in vivo. Cancer Prev Res; 11(3); 129–42. ©2017 AACR.
See related editorial by Berger and Scacheri, p. 125
A cluster randomized controlled trial of lay health worker support for prevention of mother to child transmission of HIV (PMTCT) in South Africa
Authors: Peltzer Karl , Weiss Stephen M. , Soni Manasi , Lee Tae Kyoung , Rodriguez Violeta J. , Cook Ryan , Alcaide Maria Luisa , Setswe Geoffrey , Jones Deborah L. 
Published: December 2017

AbstractBackgroundWe evaluate the impact of clinic-based PMTCT community support by trained lay health workers in addition to standard clinical care on PMTCT infant outcomes.MethodsIn a cluster randomized controlled trial, twelve community health centers (CHCs) in Mpumalanga Province, South Africa, were randomized to have pregnant women living with HIV receive either: a standard care (SC) condition plus time-equivalent attention-control on disease prevention (SC; 6 CHCs; n  = 357), or an enhanced intervention (EI) condition of SC PMTCT plus the “Protect Your Family” intervention (EI; 6 CHCs; n  = 342). HIV-infected pregnant women in the SC attended four antenatal and two postnatal video sessions and those in the EI, four antenatal and two postnatal PMTCT plus “Protect Your Family” sessions led by trained lay health workers. Maternal PMTCT and HIV knowledge were assessed. Infant HIV status at 6 weeks postnatal was drawn from clinic PCR records; at 12 months, HIV status was assessed by study administered DNA PCR. Maternal adherence was assessed by dried blood spot at 32 weeks, and infant adherence was assessed by maternal report at 6 weeks. The impact of the EI was ascertained on primary outcomes (infant HIV status at 6 weeks and 12 months and ART adherence for mothers and infants), and secondary outcomes (HIV and PMTCT knowledge and HIV transmission related behaviours). A series of logistic regression and latent growth curve models were developed to test the impact of the intervention on study outcomes.ResultsIn all, 699 women living with HIV were recruited during pregnancy (8–24 weeks), and assessments were completed at baseline, at 32 weeks pregnant (61.7%), and at 6 weeks (47.6%), 6 months (50.6%) and 12 months (59.5%) postnatally. Infants were tested for HIV at 6 weeks and 12 months, 73.5% living infants were tested at 6 weeks and 56.7% at 12 months. There were no significant differences between SC and EI on infant HIV status at 6 weeks and at 12 months, and no differences in maternal adherence at 32 weeks, reported infant adherence at 6 weeks, or PMTCT and HIV knowledge by study condition over time.ConclusionThe enhanced intervention administered by trained lay health workers did not have any salutary impact on HIV infant status, ART adherence, HIV and PMTCT knowledge.Trial registrationclinicaltrials.gov: number NCT02085356
Therapeutic heat and cryotherapy increases knee range of movement on hamstring muscles of healthy volunteers
Authors: Ananias Bethânia Minussi , Braghiroli Fernanda Lega , Prudêncio Diego Ailton , da Silveira Carolina Buzzi , Sanada Luciana Sayuri , Okubo Rodrigo 
Published: December 2017

Purpose: To investigate the effects of heat (surface and deep) and cold on the range of motion of the knee. Methods: A total of 40 volunteers were randomly allocated into four groups, with 10 participants in each group. The control group had no intervention, the infrared group received an application of surface heat conducted through an infrared device, the shortwave group received deep heating through a shortwave device, and the cryotherapy group had ice packs placed on them. A blind measurer performed the flexibility evaluation using a goniometer coupled to a board that evaluated range of movement of the knee. Data were statistically analysed by one-way analysis of variance and Tukey's comparison (for comparison between groups) and paired t-student tests (for before and after comparisons) to determine differences between groups, with a significance level of p<0.05. Findings: The infrared, cryotherapy and shortwave groups showed an increase in the range of motion compared with the control group. It was observed that the control and infrared groups showed no significant differences before and after application (p>0.05). However, the cryotherapy and shortwave groups demonstrated an effective increase (p<0.05). Conclusions: The three heating and cooling techniques caused a favourable increase of range of movement compared with no intervention. However, the shortwave and cryotherapy interventions were more effective in increasing the knee joint's range of motion.
Alexander Mann
Authors: Tejedor Estupiñan Ricardo Alonso 
Published: December 2017

Pintor nacido en Glasgow, Escocia el 22 de enero de 1853. Fue el segundo hijo de James Mann, un comerciante y conexionista exitoso. Tomó sus primeras clases de dibujo a nivel profesional con Robert Greenlees a la edad de diez años en Glasgow School of Art.
Conferec (Conference CMS)
Authors: Bawono Sahirul Alim Tri , Purnomo Fendi Aji , Purnomo Agus , Nuzuliati Rizky 
Published: December 2017

<p><em>Conference is a medium for researchers to exchange experiences. The organization of the website requires registration management, review and payment process. Web site conference management is required for these processes.</em></p><p><em>Making CMS Conference using MySQL, Apache, PHP, Codeigniter.MySQL is a program to manage the database. Apache is a program to serve the process of response and demand that is on the internet. PHP is a programming language. Codeigniter is a framework to facilitate the process of coding the program.</em></p><p><em>Results resulting from this research is CMS Conference has been successfully created with no found syntax error and error logic in the program. The main features are the management of conference display, acceptance management articles, review process management, management of the process of receiving articles and payment management</em><em></em></p><p> </p>
EXPERIMENTOS HISTÓRICOS E O ENSINO DE FÍSICA: AGREGANDO REFLEXÕES A PARTIR DA REVISÃO BIBLIOGRÁFICA DA ÁREA E DA HISTÓRIA CULTURAL DA CIÊNCIA
Authors: Jardim Wagner Tadeu , Guerra Andreia 
Published: December 2017

No presente artigo apresentamos uma discussão acerca dos objetivos de ensino encontrados na literatura relacionada ao trabalho com experimentos históricos. Como ponto de partida, realizamos uma revisão bibliográfica, nos websites de seis periódicos de grande relevância nacional para a área do ensino de ciências, e em especial, para o Ensino de Física. O critério de busca se baseou, a princípio, em trabalhos publicados entre os anos de 2001 a 2016, a partir de termos como “experimentos históricos”, “museus” e “experiência”. Em um segundo momento, devido ao grande número de publicações encontrado, foi desenvolvido um processo de triagem a partir da análise de títulos, resumos, palavras-chave e, quando necessário, do corpo do texto, tendo como intuito o de identificar quais as pesquisas enfatizavam o trabalho com experimentos históricos no ensino de Física, seja em uma perspectiva teórica, seja na manipulação de uma réplica de um aparato histórico. As propostas selecionadas foram dispostas em categorias adaptadas do trabalho de Heering e Höttecke (2014) para que pudéssemos traçar um paralelo entre a produção nacional e internacional que acabaram por apresentar escopos consonantes. Além disso, análise dos resultados nos leva a inferir que, de maneira geral, fatores extra laboratoriais, inerentes a ciência, quando não negligenciados, são colocados de maneira periférica. Assim, traçamos considerações teóricas baseadas em Historiadores da Ciência, que se pautam no viés da História Cultural da Ciência, buscando agregar reflexões ao que vem sendo desenvolvido acerca dos experimentos históricos no ensino de Física até o momento.
Poverty and Serious Mental Illness: Toward Action on a Seemingly Intractable Problem
Authors: Sylvestre John , Notten Geranda , Kerman Nick , Polillo Alexia , Czechowki Konrad 
Published: December 2017

AbstractThis paper examines the issue of poverty among people with serious mental illness (SMI), positioning it as a key issue to be confronted by community mental health systems and practitioners. The paper reviews three perspectives on poverty, considering how each sheds light on poverty among people with SMI, and their implications for action: (a) monetary resources, (b) basic needs, and (c) capabilities. The paper argues that community mental health programs and systems are currently unable to address poverty as they are overly focused on individual‐level interventions that, on their own, cannot raise people out of poverty. The paper calls for a social justice value, informed by the concept of citizenship, as a necessary complement to the recovery concept that has informed community mental health practice for almost 25 years. Finally, the paper argues that community psychologists, with their concepts, methods, and values, are well positioned to contribute to this important issue. However, it also contends that addressing poverty requires collaboration from community psychologists with researchers and practitioners from other fields and domains of expertise to begin to make progress.
Sexual Intimacy, Mental Illness, and Homelessness
Authors: Ecker John , Cherner Rebecca , Rae Jennifer , Czechowski Konrad 
Published: December 2017

AbstractThe current article reviews the literature on sexuality among individuals with a severe mental illness (SMI) who have experienced homelessness, a topic that has received little attention in the research literature, particularly from a community psychology perspective. The review begins with a synthesis of the literature on SMI and sexuality, followed by a review of the available literature on SMI, homelessness, and sexuality. It concludes with an interpretation of the findings using community psychology values and principles. The findings highlight the importance of intimate relationships to recovery for many individuals with an SMI who have experienced homelessness. Policy implications for homeless shelters and housing interventions are discussed.
SaCas9 Requires 5′‐NNGRRT‐3′ PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells
Authors: Xie Haihua , Tang Lianchao , He Xiubin , Liu Xiexie , Zhou Chenchen , Liu Junjie , Ge Xianglian , Li Jin , Liu Changbao , Zhao Junzhao , Qu Jia , Song Zongming , Gu Feng 
Published: December 2017

AbstractCRISPR/Cas9‐mediated gene therapy holds great promise for the treatment of human diseases. The protospacer adjacent motif (PAM), the sequence adjacent to the target sequence, is an essential targeting component for the design of CRISPR/Cas9‐mediated gene editing. However, currently, very few studies have attempted to directly study the PAM sequence in human cells. To address this issue, the authors develop a dual fluorescence reporter system that could be harnessed for identifying functional PAMs for genome editing endonuclease, including Cas9. With this system, the authors investigate the effects of different PAM sequences for SaCas9, which is small and has the advantage of allowing in vivo genome editing, and found only 5′‐NNGRRT‐3′ PAM could induced sufficient target cleavage with multi‐sites. The authors also found SaCas9 possesses higher activity than SpCas9 or FnCpf1 via plasmids (episomal) and chromosomes with integrated eGFP‐based comparison. Taken together, the authors show that a dual fluorescence reporter system is a means to identifying a functional PAM and quantitatively comparing the efficiency of different genome editing endonucleases with the similar or identical target sequence in human cells.
Study on the Model Structure of Human Machine Operation to Evaluate a Coincident Timing Skill
Authors: HASHIMOTO KOHJIRO , DOKI KAE , DOKI SHINJI 
Published: December 2017

SUMMARYWith an increase in the elderly population, traffic accidents caused by elderly drivers have become an important social issue in Japan. The primary factor of traffic accidents by elderly drivers is a reduction in their driving skill. Therefore, elderly drivers are required by law to conduct regularly a driving aptitude test in Japan. If the driving skill of the driver is inadequacy, he is subject to punishment, such as driver license revoked. However, there is not appropriate evaluation index of driving skill. We have proposed a modeling method of driving behavior to support one. Proposed driving behavior model is generated based on the actual driving data of driver, and the generated model has some kind of habit and pattern of the driver. Therefore, it is considered that it is possible to evaluate driving skill of a driver by analyzing the generated model. According this reason, we aim to propose a modeling method of driving behavior to evaluate driving skill. Here, a coincident timing skill of driver is focused as a driving skill. In the case of driving behavior, the execution timing of driving operations is decided based on the prediction of subsequent change of the outside environment information. The accuracy of this decided execution timing of operation depend on the above prediction is called as the coincident timing skill. In the proposed model, the causality between the situation around a person and operation of driver is modeled by Hidden Markov Model, and timing probability distribution is added to Hidden Markov Model in order to evaluate this coincident timing skill. The timing probability distribution expresses the execution timing of next operation of driver. Therefore, it is possible to detect the information of the coincident timing skill of driver from the timing probability distribution. In the experiment, the controller operation of a radio controlled vehicle is modeled by the proposed method, and the usefulness of the proposed model is examined through some experimental results.
Origin of Concentration Quenching in Ytterbium Coordination Polymers: Phonon‐Assisted Energy Transfer
Authors: Omagari Shun , Nakanishi Takayuki , Hirai Yuichi , Kitagawa Yuichi , Seki Tomohiro , Fushimi Koji , Ito Hajime , Hasegawa Yasuchika 
Published: December 2017

AbstractInvited for the cover of this issue are Takayuki Nakanishi from Hokkaido University, Sapporo, Japan, and co‐workers. The cover image shows the YbIII coordination polymer used for the investigation of the concentration quenching mechanism.
Long-lived efficient delayed fluorescence organic light-emitting diodes using n-type hosts
Authors: Cui Lin-Song , Ruan Shi-Bin , Bencheikh Fatima , Nagata Ryo , Zhang Lei , Inada Ko , Nakanotani Hajime , Liao Liang-Sheng , Adachi Chihaya 
Published: December 2017

AbstractOrganic light-emitting diodes have become a mainstream display technology because of their desirable features. Third-generation electroluminescent devices that emit light through a mechanism called thermally activated delayed fluorescence are currently garnering much attention. However, unsatisfactory device stability is still an unresolved issue in this field. Here we demonstrate that electron-transporting n-type hosts, which typically include an acceptor moiety in their chemical structure, have the intrinsic ability to balance the charge fluxes and broaden the recombination zone in delayed fluorescence organic electroluminescent devices, while at the same time preventing the formation of high-energy excitons. The n-type hosts lengthen the lifetimes of green and blue delayed fluorescence devices by > 30 and 1000 times, respectively. Our results indicate that n-type hosts are suitable to realize stable delayed fluorescence organic electroluminescent devices.