bluuebunny/crossref_metadata_2025_split huggingface dataset:
A morphing aerofoil with highly controllable aerodynamic performance
Authors: Wu R. , Soutis C. , Zhong S. , Filippone A. 
Published: November 2016

ABSTRACTIn this paper, a morphing carbon fibre composite aerofoil concept with an active trailing edge is proposed. This aerofoil features of camber morphing with multiple degrees of freedom. The shape morphing is enabled by an innovative structure driven by an electrical actuation system that uses linear ultrasonic motors (LUSM) with compliant runners, enabling full control of multiple degrees of freedom. The compliant runners also serve as structural components that carry the aerodynamic load and maintain a smooth skin curvature. The morphing structure with compliant truss is shown to exhibit a satisfactory flexibility and loading capacity in both numerical simulations and static loading tests. This design is capable of providing a pitching moment control independent of lift and higher L/D ratios within a wider angle-of-attack range. Such multiple morphing configurations could expand the flight envelope of future unmanned aerial vehicles. A small prototype is built to illustrate the concept, but as no off-the-shelf LUSMs can be integrated into this benchtop model, two servos are employed as actuators, providing two controlled degrees of freedom.
Energy restriction combined with dipeptidyl peptidase-4 inhibitor exerts neuroprotection in obese male rats
Authors: Pintana Hiranya , Tanajak Pongpan , Pratchayasakul Wasana , Sa-nguanmoo Piangkwan , Chunchai Titikorn , Satjaritanun Pattarapong , Leelarphat Linlada , Chattipakorn Nipon , Chattipakorn Siriporn C. 
Published: November 2016

AbstractDipeptidyl peptidase-4 (DDP-4) inhibitors and energy restriction (ER) are widely used to treat insulin resistance and type 2 diabetes mellitus. However, the effects of ER or the combination with vildagliptin on brain insulin sensitivity, brain mitochondrial function, hippocampal synaptic plasticity and cognitive function in obese insulin-resistant rats have never been investigated. We hypothesised that ER with DDP-4 inhibitor exerts better efficacy than ER alone in improving cognition in obese insulin-resistant male rats by restoring brain insulin sensitivity, brain mitochondrial function and hippocampal synaptic plasticity. A total of twenty-four male Wistar rats were divided into two groups and fed either a normal diet or a high-fat diet (HFD) for 12 weeks. At week 13, the HFD rats were divided into three subgroups (n 6/subgroup) to receive one of the following treatments: vehicle, ER (60 % of energy received during the previous 12 weeks) or ER plus vildagliptin (3 mg/kg per d, p.o.) for 4 weeks. At the end of the treatment, cognitive function, metabolic parameters, brain insulin sensitivity, hippocampal synaptic plasticity and brain mitochondrial function were determined. We found that HFD-fed rats demonstrated weight gain with peripheral insulin resistance, dyslipidaemia, oxidative stress, brain insulin resistance, impaired brain mitochondrial function and cognitive dysfunction. Although HFD-fed rats treated with ER and ER plus vildagliptin showed restored peripheral insulin sensitivity and improved lipid profiles, only ER plus vildagliptin rats had restored brain insulin sensitivity, brain mitochondrial function, hippocampal synaptic plasticity and cognitive function. These findings suggest that only a combination of ER with DPP-4 inhibitor provides neuroprotective effects in obese insulin-resistant male rats.
The Best Exotic Marigold Hotel: international retirement migration on film
Authors: BELL CLAUDIA 
Published: November 2016

ABSTRACTThe two movies aboutThe Best Exotic Marigold Hotel(2012 and 2015) were directed by John Madden. Starring a cast of famous British older actors, the narratives are set in a faded hotel in India. These are individuals who have relocated because their retirement dreams cannot be realised in their home country. They reflect the growing phenomenon of international retirement migration (IRM): the quickly growing upsurge of financially independent individuals seeking an affordable old age. In India they can claim a position of relative comfort and privilege. For a generation that grew up in a consumerist culture, upward mobility in the senior life stage has become a purchasable commodity through exodus to a developing country. This generation of retirees is generally in better health compared with prior seniors, with a longer life expectancy. Many have a background of travel experience, and an ethos that places their own pleasures in life as pivotal. While global numbers are unavailable, it is estimated that there are millions of retirees relocating to less-developed countries for an affordable retirement. At retirement locations such as the Marigold Hotel, the discrepancies that continue between nations, and local poverty, enable this practice. The events in these movies might be read as a recapitulation of imperialism expressed through retirement migration.
Underlying manifestations of developmental phonological disorders in French-speaking pre-schoolers
Authors: BROSSEAU-LAPRÉ FRANÇOISE , RVACHEW SUSAN 
Published: November 2016

AbstractThis study examined the psycholinguistic profiles of Quebec French-speaking children with developmental phonological disorders (DPD). The purpose was to determine whether the endophenotypes that have been identified in English-speaking children with DPD are similarly associated with speech impairment in French-speaking children. Seventy-two children with DPD and ten children with normally developing speech, aged four to six years, received a comprehensive assessment battery that included measures at the phenotype level (i.e. measures of overt speech production skills) and endophenotype level (i.e. measures of potential underlying core deficits such as phonological processing or oral motor impairments). The majority of the children with DPD presented with a psycholinguistic profile indicative of difficulties with phonological processing. Phonological processing skills also explained unique variance in speech production accuracy, indicating that French-speaking children with DPD, who produce different surface speech errors than English-speaking children with DPD, are nonetheless very similar with regards to their underlying psycholinguistic profile.
Professors as Intellectuals in China: Political Identities and Roles in a Provincial University
Authors: Hao Zhidong , Guo Zhengyang 
Published: November 2016

AbstractUnder Xi Jinping's administration, ideological control in China has been tightened and political dissent has become increasingly difficult, especially in universities. What can professors do? Our research in one university in central China finds that professors have multifaceted identities and engage in synchronous political roles as establishment/organic, non-establishment/professional and contra-establishment/critical intellectuals, although most take on the first two roles. Our research is based on 36 interviews with professors, students and administrators from various departments of this provincial university and on an analysis of the faculty's teaching and research. This paper aims to contribute to the sociology of intellectuals and higher education by illuminating how professors, as intellectuals, engage in contemporary Chinese political discourse.
Evaluation of chest radiography,lytAreal-time PCR, and other routine tests for diagnosis of community-acquired pneumonia and estimation of possible attributable fraction of pneumococcus in northern Togo
Authors: BLAKE A. , NJANPOP-LAFOURCADE B. M. , TELLES J. N. , RAJOHARISON A. , MAKAWA M. S. , AGBENOKO K. , TAMEKLOE S. , MUELLER J. E. , TALL H. , GESSNER B. D. , PARANHOS-BACCALÀ G. , MOÏSI J. C. 
Published: November 2016

SUMMARYStreptococcus pneumoniae(Spn) is a leading cause of community-acquired pneumonia (CAP), yet existing diagnostic tools remain inadequate. We aimed to evaluate laboratory and radiological methods for detecting pneumococcal aetiology in CAP patients and to estimate Spn prevalence in this group. All-aged patients hospitalized with clinically defined CAP in northern Togo were enrolled during 2010–2013. Latent class analysis pooled results of semi-automated blood culture (SABC), whole bloodlytAreal-time polymerase chain reaction (rt-PCR), serum C-reactive protein (CRP), and chest radiography (CXR) and categorized patients as likely pneumococcal or non-pneumococcal CAP. We enrolled 1684 patients; 1501 had results for all tests. CXR, SABC,lytArt-PCR and CRP >71·2 mg/l had sensitivities of 94% [95% confidence interval (CI) 87–100], 13% (95% CI 10–16), 17% (95% CI 14–21) and 78% (95% CI 75–80), and specificities of 88% (95% CI 84–93), 100% (95% CI 99–100), 97% (95% CI 96–99) and 77% (95% CI 75–79), respectively. Pneumococcal attributable proportion was 34% (95% CI 32–37), increasing with age and in men. We estimated that Spn caused one third of CAP. Whole bloodlytArt-PCR was more sensitive than SABC; both had low sensitivity and high specificity. Conversely CXR was highly sensitive and reasonably specific; it could be a useful tool for epidemiological studies aiming to define Spn pneumonia incidence across all ages.
Neuroscience Fiction as Eidolá: Social Reflection and Neuroethical Obligations in Depictions of Neuroscience in Film
Authors: WURZMAN RACHEL , YADEN DAVID , GIORDANO JAMES 
Published: November 2016

Abstract:Neuroscience and neurotechnology are increasingly being employed to assess and alter cognition, emotions, and behaviors, and the knowledge and implications of neuroscience have the potential to radically affect, if not redefine, notions of what constitutes humanity, the human condition, and the “self.” Such capability renders neuroscience a compelling theme that is becoming ubiquitous in literary and cinematic fiction. Such neuro-SciFi (or “NeuroS/F”) may be seen as eidolá: a created likeness that can either accurately—or superficially, in a limited way—represent that which it depicts. Such eidolá assume discursive properties implicitly, as emotionally salient references for responding to cultural events and technological objects reminiscent of fictional portrayal; and explicitly, through characters and plots that consider the influence of neurotechnological advances from various perspectives. We argue that in this way, neuroS/F eidolá serve as allegorical discourse on sociopolitical or cultural phenomena, have power to restructure technological constructs, and thereby alter the trajectory of technological development. This fosters neuroethical responsibility for monitoring neuroS/F eidolá and the sociocultural context from which—and into which—the ideas of eidolá are projected. We propose three approaches to this: evaluating reciprocal effects of imaginary depictions on real-world neurotechnological development; tracking changing sociocultural expectations of neuroscience and its uses; and analyzing the actual process of social interpretation of neuroscience to reveal shifts in heuristics, ideas, and attitudes. Neuroethicists are further obliged to engage with other discourse actors about neuroS/F interpretations to ensure that meanings assigned to neuroscientific advances are well communicated and more fully appreciated.
The Dialectic between Confrontation and Commitment: Religious-Zionism and the Settlement Project
Authors: Hellinger Moshe , Hershkowitz Isaac , Susser Bernard 
Published: November 2016

AbstractReligious Zionists have been the driving force behind the settlement project in Israel for the past 40 years. They often see settling in the Greater Land of Israel as a messianic activity. It might be thought that when state policy clashes with radical messianic movements, the result would be violent, bloody confrontations. This study seeks to explain why this has not been the case in Israel despite the dismantling of settlements in the Sinai and Gaza and the controversial Oslo process. Although there has been turmoil and resistance, most religious Zionists have refrained from serious violence. We suggest that a “theological-normative balance” prevents all-out de-legitimation of the state and life-threatening violence against it.
Salinity tolerance loci revealed in rice using high-throughput non-invasive phenotyping
Authors: Al-Tamimi Nadia , Brien Chris , Oakey Helena , Berger Bettina , Saade Stephanie , Ho Yung Shwen , Schmöckel Sandra M. , Tester Mark , Negrão Sónia 
Published: November 2016

AbstractHigh-throughput phenotyping produces multiple measurements over time, which require new methods of analyses that are flexible in their quantification of plant growth and transpiration, yet are computationally economic. Here we develop such analyses and apply this to a rice population genotyped with a 700k SNP high-density array. Two rice diversity panels, indica and aus, containing a total of 553 genotypes, are phenotyped in waterlogged conditions. Using cubic smoothing splines to estimate plant growth and transpiration, we identify four time intervals that characterize the early responses of rice to salinity. Relative growth rate, transpiration rate and transpiration use efficiency (TUE) are analysed using a new association model that takes into account the interaction between treatment (control and salt) and genetic marker. This model allows the identification of previously undetected loci affecting TUE on chromosome 11, providing insights into the early responses of rice to salinity, in particular into the effects of salinity on plant growth and transpiration.
Axin2-expressing cells execute regeneration after skeletal injury
Authors: Ransom R. C. , Hunter D. J. , Hyman S. , Singh G. , Ransom S. C. , Shen E. Z. , Perez K. C. , Gillette M. , Li J. , Liu B. , Brunski J. B. , Helms J. A. 
Published: November 2016

AbstractThe mammalian skeleton performs a diverse range of vital functions, requiring mechanisms of regeneration that restore functional skeletal cell populations after injury. We hypothesized that the Wnt pathway specifies distinct functional subsets of skeletal cell types, and that lineage tracing of Wnt-responding cells (WRCs) using the Axin2 gene in mice identifies a population of long-lived skeletal cells on the periosteum of long bone. Ablation of these WRCs disrupts healing after injury, and three-dimensional finite element modeling of the regenerate delineates their essential role in functional bone regeneration. These progenitor cells in the periosteum are activated upon injury and give rise to both cartilage and bone. Indeed, our findings suggest that WRCs may serve as a therapeutic target in the setting of impaired skeletal regeneration.
Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts
Authors: Ghayad Sandra E. , Rammal Ghina , Ghamloush Farah , Basma Hussein , Nasr Rihab , Diab-Assaf Mona , Chelala Claude , Saab Raya 
Published: November 2016

AbstractRhabdomyosarcoma (RMS) is an aggressive childhood soft tissue tumor, which exists in oncoprotein PAX-FOXO1 fusion positive and fusion negative subtypes, with the fusion-positive RMS being characterized by a more aggressive clinical behavior. Exosomes are small membranous vesicles secreted into body fluids by multiple cell types, including tumor cells, and have been implicated in metastatic progression through paracrine signaling. We characterized exosomes secreted by a panel of 5 RMS cell lines. Expression array analysis showed that, for both fusion-positive and fusion-negative cells, exosome miRNA clustered well together and to a higher extent than cellular miRNA. While enriched miRNA in exosomes of fusion-negative RMS cells were distinct from those of fusion-positive RMS cells, the most significant predicted disease and functions in both groups were related to processes relevant to cancer and tissue remodelling. Functionally, we found that RMS-derived exosomes exerted a positive effect on cellular proliferation of recipient RMS cells and fibroblasts, induced cellular migration and invasion of fibroblasts, and promoted angiogenesis. These findings show that RMS-derived exosomes enhance invasive properties of recipient cells, and that exosome content of fusion-positive RMS is different than that of fusion-negative RMS, possibly contributing to the different metastatic propensity of the two subtypes.
Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy
Authors: Kue Chin Siang , Kamkaew Anyanee , Voon Siew Hui , Kiew Lik Voon , Chung Lip Yong , Burgess Kevin , Lee Hong Boon 
Published: November 2016

AbstractTropomyosin receptor kinase C (TrkC) targeted ligand-photosensitizer construct, IYIY-diiodo-boron-dipyrromethene (IYIY-I2-BODIPY) and its scrambled counterpart YIYI-I2-BODIPY have been prepared. IYIY-I2-BODIPY binds TrkC similar to neurotrophin-3 (NT-3), and NT-3 has been reported to modulate immune responses. Moreover, it could be shown that photodynamic therapy (PDT) elevates antitumor immune responses. This prompted us to investigate the immunological impacts mediated by IYIY-I2-BODIPY in pre- and post-PDT conditions. We demonstrated that IYIY-I2-BODIPY (strong response) and YIYI-I2-BODIPY (weak response) at 10 mg/kg, but not I2-BODIPY control, increased the levels of IL-2, IL-4, IL-6 and IL-17, but decreased the levels of systemic immunoregulatory mediators TGF-β, myeloid-derived suppressor cells and regulatory T-cells. Only IYIY-I2-BODIPY enhanced the IFN-γ+ and IL-17+ T-lymphocytes, and delayed tumor growth (~20% smaller size) in mice when administrated daily for 5 days. All those effects were observed without irradiation; when irradiated (520 nm, 100 J/cm2, 160 mW/cm2) to produce PDT effects (drug-light interval 1 h), IYIY-I2-BODIPY induced stronger responses. Moreover, photoirradiated IYIY-I2-BODIPY treated mice had high levels of effector T-cells compared to controls. Adoptive transfer of immune cells from IYIY-I2-BODIPY-treated survivor mice that were photoirradiated gave significantly delayed tumor growth (~40–50% smaller size) in recipient mice. IYIY-I2-BODIPY alone and in combination with PDT modulates the immune response in such a way that tumor growth is suppressed. Unlike immunosuppressive conventional chemotherapy, IYIY-I2-BODIPY can act as an immune-stimulatory chemotherapeutic agent with potential applications in clinical cancer treatment.
Resting-state high-frequency heart rate variability is related to respiratory frequency in individuals with severe mental illness but not healthy controls
Authors: Quintana Daniel S. , Elstad Maja , Kaufmann Tobias , Brandt Christine L. , Haatveit Beathe , Haram Marit , Nerhus Mari , Westlye Lars T. , Andreassen Ole A. 
Published: November 2016

AbstractHeart rate variability (HRV) has become central to biobehavioral models of self-regulation and interpersonal interaction. While research on healthy populations suggests changes in respiratory frequency do not affect short-term HRV, thus negating the need to include respiratory frequency as a HRV covariate, the nature of the relationship between these two variables in psychiatric illness is poorly understood. Therefore, the aim of this study was to investigate the association between HRV and respiratory frequency in a sample of individuals with severe psychiatric illness (n = 55) and a healthy control comparison group (n = 149). While there was no significant correlation between HF-HRV and respiration in the control group, we observed a significant negative correlation in the psychiatric illness group, with a 94.1% probability that these two relationships are different. Thus, we provide preliminary evidence suggesting that HF-HRV is related to respiratory frequency in severe mental illness, but not in healthy controls, suggesting that HRV research in this population may need to account for respiratory frequency. Future work is required to better understand the complex relationship between respiration and HRV in other clinical samples with psychiatric diseases.
Digital Detection of Exosomes by Interferometric Imaging
Authors: Daaboul George G. , Gagni Paola , Benussi Luisa , Bettotti Paolo , Ciani Miriam , Cretich Marina , Freedman David S. , Ghidoni Roberta , Ozkumur Ayca Yalcin , Piotto Chiara , Prosperi Davide , Santini Benedetta , Ünlü M. Selim , Chiari Marcella 
Published: November 2016

AbstractExosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis, and early disease diagnostics. The small size (30–100 nm) along with low refractive index contrast of exosomes makes direct characterization and phenotypical classification very difficult. In this work we present a method based on Single Particle Interferometric Reflectance Imaging Sensor (SP-IRIS) that allows multiplexed phenotyping and digital counting of various populations of individual exosomes (>50 nm) captured on a microarray-based solid phase chip. We demonstrate these characterization concepts using purified exosomes from a HEK 293 cell culture. As a demonstration of clinical utility, we characterize exosomes directly from human cerebrospinal fluid (hCSF). Our interferometric imaging method could capture, from a very small hCSF volume (20 uL), nanoparticles that have a size compatible with exosomes, using antibodies directed against tetraspanins. With this unprecedented capability, we foresee revolutionary implications in the clinical field with improvements in diagnosis and stratification of patients affected by different disorders.
Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain
Authors: Shimada Naoto , Inami Show , Sato Shoma , Kitamoto Toshihiro , Sakai Takaomi 
Published: November 2016

AbstractApterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the neurons expressing PDF, a neuropeptide, play important roles in proper sleep/wake regulation in adult flies. PDF-expressing neurons consist of two neuronal clusters: small ventral-lateral neurons (s-LNvs) acting as the circadian pacemaker and large ventral-lateral neurons (l-LNvs) regulating light-driven arousal. We identified that Ap localizes to the nuclei of s-LNvs and l-LNvs. In light-dark (LD) cycles, RNAi knockdown or the targeted expression of dominant-negative forms of Ap or Chi in PDF-expressing neurons or l-LNvs promoted arousal. In contrast, in constant darkness, knockdown of Ap in PDF-expressing neurons did not promote arousal, indicating that a reduced Ap function in PDF-expressing neurons promotes light-driven arousal. Furthermore, Ap expression in l-LNvs showed daily rhythms (peaking at midnight), which are generated by a direct light-dependent mechanism rather than by the endogenous clock. These results raise the possibility that the daily oscillation of Ap expression in l-LNvs may contribute to the buffering of light-driven arousal in wild-type flies.