bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sublethal effects of buprofezin on development and reproduction in the white-backed planthopper, Sogatella furcifera (Hemiptera: Delphacidae)
Authors: Ali Ehsan , Liao Xun , Yang Peng , Mao Kaikai , Zhang Xiaolei , Shakeel Muhammad , Salim Abdalla M. A. , Wan Hu , Li Jianhong 
Published: November 2017

AbstractIn the present study, the effects of sublethal concentrations of buprofezin on life-table traits ofS. furciferawere evaluated for two consecutive generations (F0 and F1). Our results exhibited that the fecundity, life span (longevity) and hatchability of the F0 and F1 generations were significantly decreased at LC30compared to the control. However, copulation was not significantly affected for the F0 or F1 generations at sublethal concentrations. The female life span was affected negatively at both treatments in F0 and at LC30in F1, compared to the control. Furthermore, significant effects of the sublethal concentrations were found on the developmental rate of all instars except the 3rdinstar of F1. However, the pre-adult period, total pre-oviposition period (TPOP) and adult pre-oviposition period (APOP) significantly increased in F1 individuals at LC30and LC10compared to the control. Our findings revealed that demographic characters (survival rate, intrinsic rate of increase (ri), finite rate of increase (λ), net reproductive rate (R0), and gross reproductive rate (GRR)) of the F1 generation (from F0 parents) significantly decreased compared to the untreated group; however, the generation time (T) increased at LC10. Therefore, the results suggested that buprofezin could adversely affect individuals in the successive generation.
Up-regulatedmiR-500aenhances hepatocarcinoma metastasis by repressing PTEN expression
Authors: Zhao Yufeng , Wang Yuehui , Wang Yaqiang 
Published: November 2017

It has been shown that miR-500a may play an important role in the metastasis of hepatocarcinoma. The present study is to explore the influence of miR-500a on hepatocarcinoma proliferation and metastasis, and the related molecular mechanism. The levels of miR-500a in the serum and tissues of patients with metastatic or non-metastatic hepatocarcinoma or normal people were determined by quantitative reverse transcription-PCR (qRT-PCR). The proliferation, invasion, and cloning of hepatocarcinoma cell lines SMMC-7721 after transfection with mimic miR-500a or inhibitor miR-500a were determined. Luciferase reported assay was used to explore the relationship between miR-500a and phosphatase and tensin homologue (PTEN). Then, the protein expression of PTEN, p-Akt (S473), p-Akt (T308), Akt, p-mTOR, mTOR, p-4E-BP1, 4E-BP1, p-S6K, and S6K in SMMC-7721 cells were also determined by Western blotting. The expression of miR-500a in patients with metastatic hepatocarcinoma was significantly higher than the non-metastatic hepatocarcinoma. Overexpression of miR-500a promoted the proliferation, invasion, and cloning of SMMC-7721 cells. Luciferase reported assay showed miR-500a could directly target at 3′-UTR of PTEN. Overexpression of miR-500a significantly reduced the expression of PTEN, and enhanced phosphorylation of Akt, mTOR, S6K, and 4E-BP1. In conclusion, the expression of miR-500a was related to the proliferation and metastasis of hepatocarcinoma, which may be partly because of the activation of AKT/mTOR pathway through targetting PTEN.
Luminosities and mass-loss rates of Local Group AGB stars and red supergiants
Authors: Groenewegen M. A. T. , Sloan G. C. 
Published: November 2017

Context. Mass loss is one of the fundamental properties of asymptotic giant branch (AGB) stars, and through the enrichment of the interstellar medium, AGB stars are key players in the life cycle of dust and gas in the universe. However, a quantitative understanding of the mass-loss process is still largely lacking.
Aims. We aim to investigate mass loss and luminosity in a large sample of evolved stars in several Local Group galaxies with a variety of metalliticies and star-formation histories: the Small and Large Magellanic Cloud, and the Fornax, Carina, and Sculptor dwarf spheroidal galaxies (dSphs).
Methods. Dust radiative transfer models are presented for 225 carbon stars and 171 oxygen-rich evolved stars in several Local Group galaxies for which spectra from the Infrared Spectrograph on Spitzer are available. The spectra are complemented with available optical and infrared photometry to construct spectral energy distributions. A minimization procedure was used to determine luminosity and mass-loss rate (MLR). Pulsation periods were derived for a large fraction of the sample based on a re-analysis of existing data.
Results. New deep K-band photometry from the VMC survey and multi-epoch data from IRAC (at 4.5 μm) and AllWISE and NEOWISE have allowed us to derive pulsation periods longer than 1000 days for some of the most heavily obscured and reddened objects. We derive (dust) MLRs and luminosities for the entire sample. The estimated MLRs can differ significantly from estimates for the same objects in the literature due to differences in adopted optical constants (up to factors of several) and details in the radiative transfer modelling. Updated parameters for the super-AGB candidate MSX SMC 055 (IRAS 00483−7347) are presented. Its current mass is estimated to be 8.5 ± 1.6 M⊙, suggesting an initial mass well above 8 M⊙ in agreement with estimates based on its large Rubidium abundance. Using synthetic photometry, we present and discuss colour-colour and colour-magnitude diagrams which can be expected from the James Webb Space Telescope.
Transient events in bright debris discs: Collisional avalanches revisited
Authors: Thebault P. , Kral Q. 
Published: November 2017

Context. A collisional avalanche is set off by the breakup of a large planetesimal, releasing vast amounts of small unbound grains that enter a debris disc located further away from the star, triggering there a collisional chain reaction that could potentially create detectable transient structures.
Aims. We investigate this mechanism, using for the first time a fully self-consistent code coupling dynamical and collisional evolutions. We also quantify for the first time the photometric evolution of the system and investigate whether or not avalanches could explain the short-term luminosity variations recently observed in some extremely bright debris discs.
Methods. We use the state-of-the-art LIDT-DD code. We consider an avalanche-favoring A6V star, and two set-ups: a “cold disc” case, with a dust release at 10 au and an outer disc extending from 50 to 120 au, and a “warm disc” case with the release at 1 au and a 5−12 au outer disc. We explore, in addition, two key parameters: the density (parameterized by its optical depth τ) of the main outer disc and the amount of dust released by the initial breakup.
Results. We find that avalanches could leave detectable structures on resolved images, for both “cold” and “warm” disc cases, in discs with τ of a few 10-3, provided that large dust masses (≳1020−5 × 1022 g) are initially released. The integrated photometric excess due to an avalanche is relatively limited, less than 10% for these released dust masses, peaking in the λ ~ 10−20 μm domain and becoming insignificant beyond ~40–50 μm. Contrary to earlier studies, we do not obtain stronger avalanches when increasing τ to higher values. Likewise, we do not observe a significant luminosity deficit, as compared to the pre-avalanche level, after the passage of the avalanche. These two results concur to make avalanches an unlikely explanation for the sharp luminosity drops observed in some extremely bright debris discs. The ideal configuration for observing an avalanche would be a two-belt structure, with an inner belt (at ~1 or ~10 au for the “warm” and “cold” disc cases, respectively) of fractional luminosity f ≳ 10-4 where breakups of massive planetesimals occur, and a more massive outer belt, with τ of a few 10-3, into which the avalanche chain reaction develops and propagates.
Multi-model ensemble projections of European river floods and high flows
at 1.5, 2, and 3 degrees global warming
Authors: Thober Stephan , Kumar Rohini , Wanders Niko , Marx Andreas , Pan Ming , Rakovec Oldrich , Samaniego Luis , Sheffield Justin , Wood Eric F , Zink Matthias 
Published: November 2017

Abstract
Severe river floods often result in huge economic losses and fatalities. Since 1980,
almost 1500 such events have been reported in Europe. This study investigates climate
change impacts on European floods under 1.5, 2, and 3 K global warming. The impacts
are assessed employing a multi-model ensemble containing three hydrologic models
(HMs: mHM, Noah-MP, PCR-GLOBWB) forced by five CMIP5 general circulation models
(GCMs) under three Representative Concentration Pathways (RCPs 2.6, 6.0, and 8.5).
This multi-model ensemble is unprecedented with respect to the combination of its
size (45 realisations) and its spatial resolution, which is 5 km over the entirety of
Europe. Climate change impacts are quantified for high flows and flood events,
represented by 10% exceedance probability and annual maxima of daily streamflow,
respectively. The multi-model ensemble points to the Mediterranean region as a
hotspot of changes with significant decrements in high flows from −11% at 1.5 K up to
−30% at 3 K global warming mainly resulting from reduced precipitation. Small changes
(< ±10%) are observed for river basins in Central Europe and the British Isles
under different levels of warming. Projected higher annual precipitation increases
high flows in Scandinavia, but reduced snow melt equivalent decreases flood events in
this region. Neglecting uncertainties originating from internal climate variability,
downscaling technique, and hydrologic model parameters, the contribution by the GCMs
to the overall uncertainties of the ensemble is in general higher than that by the
HMs. The latter, however, have a substantial share in the Mediterranean and
Scandinavia. Adaptation measures for limiting the impacts of global warming could be
similar under 1.5 K and 2 K global warming, but have to account for significantly
higher changes under 3 K global warming.
Designing Climate Policy: Lessons from the Renewable Fuel Standard and the Blend Wall
Authors: Lade Gabriel E , Cynthia Lin Lawell C‐Y , Smith Aaron 
Published: November 2017

AbstractMany policies mandate renewable energy production to combat global climate change. These policies often differ significantly from first‐best policy prescriptions. Among the largest renewable energy mandates enacted to date is the Renewable Fuel Standard (RFS), which mandates biofuel consumption far beyond what is feasible with current technology and infrastructure. We critically review the methods used by the Environmental Protection Agency to project near‐ and long‐term compliance costs under the RFS, and draw lessons from the RFS experience to date that would improve the program's efficiency. The lessons are meant to inform both future RFS rulemaking and the design of future climate policies. We draw two lessons specific to the RFS. First, incorporate uncertainty into rulemaking; second, implement multi‐year rules. Multi‐year rulemaking allows for longer periods between major regulatory decisions and sends greater certainty to markets. We also provide two more general recommendations: tie waiver authority to compliance costs or include cost containment provisions, and fund research and development of new technologies directly rather than mandating them. Future technological advancement is uncertain, and mandating new technologies has proven to be largely ineffective to date, particularly in fuel markets.
SimulaTE: simulating complex landscapes of transposable elements of populations
Authors: Kofler Robert 
Published: November 2017

AbstractMotivationEstimating the abundance of transposable elements (TEs) in populations (or tissues) promises to answer many open research questions. However, progress is hampered by the lack of concordance between different approaches for TE identification and thus potentially unreliable results.ResultsTo address this problem, we developed SimulaTE a tool that generates TE landscapes for populations using a newly developed domain specific language (DSL). The simple syntax of our DSL allows for easily building even complex TE landscapes that have, for example, nested, truncated and highly diverged TE insertions. Reads may be simulated for the populations using different sequencing technologies (PacBio, Illumina paired-ends) and strategies (sequencing individuals and pooled populations). The comparison between the expected (i.e. simulated) and the observed results will guide researchers in finding the most suitable approach for a particular research question.Availability and implementationSimulaTE is implemented in Python and available at https://sourceforge.net/projects/simulates/. Manual https://sourceforge.net/p/simulates/wiki/Home/#manual; Test data and tutorials https://sourceforge.net/p/simulates/wiki/Home/#walkthrough; Validation https://sourceforge.net/p/simulates/wiki/Home/#validation.
Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration
Authors: You Baiyang , Liu Yanbo , Chen Jia , Huang Xiao , Peng Huihui , Liu Zhaoya , Tang Yixin , Zhang Kai , Xu Qian , Li Xiaohui , Cheng Guangjie , Shi Ruizheng , Zhang Guogang 
Published: November 2017

AbstractAimsReactive oxygen species (ROS) play essential roles in the pulmonary vascular remodelling associated with hypoxia-induced pulmonary hypertension (PH). Vascular peroxidase 1 (VPO1) is a newly identified haeme-containing peroxidase that accelerates oxidative stress development in the vasculature. This study aimed to determine the potential role of VPO1 in hypoxia-induced PH-related vascular remodelling.Methods and resultsThe vascular morphology and VPO1 expression were assessed in the pulmonary arteries of Sprague–Dawley (SD) rats. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) and VPO1 expression and HOCl production were significantly increased in hypoxic rats, which also exhibited obvious vascular remodelling. Furthermore, a hypoxia-induced PH model was generated by exposing primary rat pulmonary artery smooth muscle cells (PASMCs) to hypoxic conditions (3% O2, 48 h), which significantly increased the expression of NOX4 and VPO1 and the production of HOCl. These hypoxic changes were accompanied by enhanced proliferation, apoptosis resistance, and migration. In PASMCs, hypoxia-induced changes, including effects on the expression of cell cycle regulators (cyclin B1 and cyclin D1), apoptosis-related proteins (bax, bcl-2, and cleaved caspase-3), migration promoters (matrix metalloproteinases 2 and 9), and NF-κB expression, as well as the production of HOCl, were all inhibited by silencing VPO1 with small interfering RNAs. Moreover, treatment with HOCl under hypoxic conditions upregulated NF-κB expression and enhanced proliferation, apoptosis resistance, and migration in PASMCs, whereas BAY 11-7082 (an inhibitor of NF-κB) significantly inhibited these effects.ConclusionCollectively, these results demonstrate that VPO1 promotes hypoxia-induced proliferation, apoptosis resistance, and migration in PASMCs via the NOX4/VPO1/HOCl/NF-κB signalling pathway.
How to convene an international health or development commission: ten key steps
Authors: Yamey Gavin , Summers Lawrence H , Jamison Dean T , Brinton Jessica 
Published: November 2017

Abstract
The Commission on Investing in Health (CIH), an international group of 25 economists and global health experts, published its Global Health 2035 report in The Lancet in December 2013. The report laid out an ambitious investment framework for achieving a “grand convergence” in health—a universal reduction in deaths from infectious diseases and maternal and child health conditions—within a generation. This article captures ten key elements that the CIH found important to its process and successful outcomes. The elements are presented in chronological order, from inception to post-publication activities. The starting point is to identify the gap that a new commission could help to narrow. A critical early step is to choose a chair who can help to set the agenda, motivate the commissioners, frame the commission’s analytic work, and run the commission meetings in an effective way. In selecting commissioners, important considerations are their technical expertise, ensuring diversity of people and viewpoints, and the connections that commissioners have with the intended policy audience. Financial and human resources need to be secured, typically from universities, foundations, and development agencies. It is important to set a clear end date, so that the commission’s work program, the timing of its meetings and its interim deadlines can be established. In-person meetings are usually a more effective mechanism than conference calls for gaining commissioners’ inputs, surfacing important debates, and ‘reality testing’ the commission’s key findings and messages. To have policy impact, the commission report should ideally say something new and unexpected and should have simple messages. Generating new empirical data and including forward-looking recommendations can also help galvanize policy action. Finally, the lifespan of a commission can be extended if it lays the foundation for a research agenda that is then taken up after the commission report is published.
Golod–Shafarevich-Type Theorems and Potential Algebras
Authors: Iyudu Natalia , Smoktunowicz Agata 
Published: November 2017

Abstract
Potential algebras feature in the minimal model program and noncommutative resolution of singularities, and the important cases are when they are finite dimensional, or of linear growth. We develop techniques, involving Gröbner basis theory and generalized Golod–Shafarevich-type theorems for potential algebras, to determine finiteness conditions in terms of the potential. We consider two-generated potential algebras. Using Gröbner bases techniques and arguing in terms of associated truncated algebra we prove that they cannot have dimension smaller than 8. This answers a question of Wemyss [21], related to the geometric argument of Toda [17]. We derive from the improved version of the Golod–Shafarevich theorem, that if the potential has only terms of degree 5 or higher, then the potential algebra is infinite dimensional. We prove that potential algebra for any homogeneous potential of degree $n\geqslant 3$ is infinite dimensional. The proof includes a complete classification of all potentials of degree 3. Then we introduce a certain version of Koszul complex, and prove that in the class $\mathcal {P}_{n}$ of potential algebras with homogeneous potential of degree $n+1\geqslant 4$, the minimal Hilbert series is $H_{n}=\frac {1}{1-2t+2t^{n}-t^{n+1}}$, so they are all infinite dimensional. Moreover, growth could be polynomial (but nonlinear) for the potential of degree 4, and is always exponential for potential of degree starting from 5. For one particular type of potential we prove a conjecture by Wemyss, which relates the difference of dimensions of potential algebra and its abelianization with Gopakumar–Vafa invariants.
Beauty, Effort, and Misrepresentation: How Beauty Work Affects Judgments of Moral Character and Consumer Preferences
Authors: Samper Adriana , Yang Linyun W , Daniels Michelle E 
Published: November 2017

AbstractWomen engage in a variety of beauty practices, or “beauty work,” to enhance their physical appearance, such as applying cosmetics, tanning, or exercising. Although the rewards of physical attractiveness are well documented, perceptions of both the women who engage in efforts to enhance their appearance and the high-effort beauty products marketed to them are not well understood. Across seven studies, we demonstrate that consumers judge women who engage in certain types of extensive beauty work as possessing poorer moral character. These judgments occur only for effortful beauty work perceived as transformative (significantly altering appearance) and transient (lasting a relatively short time), such that they emerge within cosmetics and tanning, yet not skincare or exercise. This effect is mediated by the perception that putting high effort into one’s appearance signals a willingness to misrepresent one’s true self, and translates into lower purchase intentions for higher-effort cosmetics. We identify several boundary conditions, including the attractiveness of the woman performing the beauty work and whether the effort is attributed to external norms or causes. In examining how beauty work elicits moral judgments, we also shed light on why effortful cosmetic use is viewed negatively, yet effortful products continue to be commercially successful.
Pattern of Methamphetamine Use and the Time Lag to Methamphetamine Dependence
Authors: Yimsaard Pongkwan , Maes Michael M. , Verachai Viroj , Kalayasiri Rasmon 
Published: November 2017

Objectives:
Use of methamphetamine (MA) commonly co-occurs with the use of other substances. The present study aims to examine substance initiation patterns of other substances, including alcohol, nicotine, inhalants, and cannabis (OTH), in MA users and its consequence on the time lag of MA dependence.

Methods:
Sociodemographic, environmental, and clinical data were obtained from MA users at a Thai substance treatment center. The Semi-Structured Assessment for Drug Dependence and Alcoholism was employed to diagnose drug dependence.

Results:
Of 991 MA users, 52.6% were males, and the average age was 26.8 ± 7.1 years. The mean age of first MA use (18 years) was greater than the mean age of first use of alcohol (17 years), nicotine (16 years), and inhalants (15 years) (P < 0.001), but was comparable with the mean age at the first use of cannabis (P > 0.05). Family history of MA use and nicotine dependence were associated with early MA onset. Participants who used MA as their first drug (MA>OTH) were more likely to be female and less likely to smoke intensely and to be exposed to severe traumatic events than those who used MA later than other substances (OTH>MA). The time lag from age at onset of MA use to MA dependence was shorter in OTH>MA than in MA>OTH (3 vs 5 years; χ2 = 5.7, P = 0.02, log-rank test).

Conclusions:
A higher proportion of women was observed in MA>OTH than in OTH>MA. The use of other substances before MA increases the individual's vulnerability in shortening the interval between age at onset of MA use and MA dependence in a substance treatment cohort.