bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective Effect of SGLT2i on contrast-induced AKI after Angiography in Patients with Type 2 Diabetes Mellitus and Chronic Coronary Syndrome: A 6-year Ambispective Cohort Study and Meta-analysis
Authors: ZHAO Zinan , ZHANG Tianqi , ZHANG Yatong , TIAN Chao , YANG Chenguang , LAN Ming , ZHANG Chi , HU Xin , JIN Pengfei , LIU Deping 
Published: October 2024

Abstract

Background SGLT2 inhibitor (SGLT2i) may reduce the risk of contrast-induced acute kidney injury (CI-AKI) in patients with type 2 diabetes mellitus (T2DM) with chronic coronary syndrome (CCS) undergoing angiography. However, the evidence is still inconclusive. We aimed to conduct a real world study and systematically review to provide updated and larger-scale evidence.
Study design: Ambispective Cohort Study and Meta-analysis.
Setting & population: Patients with T2DM and CCS.
Methods The data was obtained from December 2017 to July 2024. Propensity score techniques were applied to enhance between-group comparability. We analyzed CI-AKIESUR and CI-AKIKDIGO and conducted subgroup analyses based on the types of angiographic procedures, including percutaneous coronary interventions (PCI), coronary arteriography (CAG), and Coronary Computed Tomographic Angiography (CCTA). We retrieved similar cohort studies from the literature to perform a meta-analysis. Results from trials reporting CI-AKIESUR and/or CI-AKIKDIGO rates among patients randomized to SGLT2i versus placebo were also meta-analysed.
Results A total of 2,350 patients receiving dapagliflozin and 16,251 patients did not receiving any SGLT2i were included before PSM. 2,071 SGLT2i users were matched with 2,071 control patients. The incidence of primary outcome 1 and 2 were both significant lower in SGLT2i group than in the control group, which were both confirmed before and after PSM analysis. Subgroup analysis showed that the incidence of CI-AKI in the SGLT2i group was significantly lower after either PCI, CAG or CCTA. The meta-analysis of cohort studies further confirmed this result, that is, the rate of CI-AKI occurrence after angiography in the SGLT2i group was significantly lower than in the control group regardless of which criterion for CI-AKI was used.
Limitations Results may be limited by single-center nature, inevitable sample selection bias, etc. and subgroup analysis of angiography operation types was conducted.
Conclusion In real-world T2DM patients, SGLT2i was associated with lower CI-AKI risk.
Clinical trial registration: Chinese Clinical Trial Registry, identifier: ChiCTR2300076484
Fabrication of biocompatible artificial skin for full-thickness wound by co-culture of adipose mesenchymal stem cells-human keratinocytes on oxygen-producing nanofiber electrospun scaffold in rat animal model
Authors: Azari Arezo , Hosseinzadeh Simzar , Abbaszadeh Hojjat Allah , Rahimpour Azam , Shahghasempour Lida , Fattahi Roya 
Published: October 2024

Abstract

In wound healing and skin regeneration, hypoxia is a significant limitation that delays this process. Lack of oxygen can lead to cell death and postpone tissue regeneration. Hence, eliminating the absence of oxygen by generating oxygen from an oxygen-generating scaffold can accelerate the skin's healing process. In our previous study, after making a scaffold with three components of polyurethane-polycaprolactone-gelatin-sodium bicarbonate, the scaffold was characterized, and the amount of oxygen release was measured, and in the next step, keratinocyte and mesenchymal cells, respectively, with a ratio of 70 to 30 were cultured. The morphology of the cells on the scaffold, the number of cells on the scaffold, and the bioavailability of the scaffold were further studied. Then, after ensuring the increase in the expression of skin-specific genes, it was transplanted into rats in the present study, and then, as a biocompatible skin substitute, its effect on the wound healing process for full-thickness skin defects was investigated in the rat model.
At the end of 3,7,10, and 14 days after surgery, the macroscopic and histopathological characteristics were evaluated at the end of 14 days after surgery. Results show that our designed scaffold groups accelerate the wound healing process compared to the control group. Scaffold 2/5% SPC+ co-culture groups demonstrated more wound repair efficacy.
Animal results show that the effective release of oxygen from the scaffold leads to the acceleration of wound healing, the increase of angiogenesis, and the formation of granulation tissue in the early stages of the healing process, which can increase its therapeutic potential. It is proposed for regenerative medicine and skin tissue engineering platforms. Therefore, our study supports using oxygen-releasing scaffolds as a potential strategy to accelerate skin regeneration.
The Effect of Urbanization and Associated Climate Change on GNSS Positioning: A Case Study in Addis Ababa City, Ethiopia
Authors: Kastro Ephson , Lewi Elias 
Published: October 2024

Abstract

Fast urbanization and associated micro-climate change in urban settings affect the day-to-day activities of contemporary dwellers. This can also affect the positioning of points using the Global Navigation Satellite System(GNSS) technique. To investigate the association between urbanization, change in the urban climate, and long-term change in the propagation of GNSS signal through the atmosphere in Addis Ababa City, the data from the International GNSS Service (IGS) station ADIS was processed for the years from 2008 to 2019. Similarly, the built-up area expansion, vegetation cover change, and land surface temperature were computed from 2005 to 2019. For all the data sets, the low-frequency variations are then estimated using a polynomial fitting technique, through the least-square approach. The comparison of the resulting long-wavelength data, using the linear correlation technique showed that there is a very high correlation between the long-term changes in the Up direction of the IGS station ADIS, and the built-up expansion, the vegetation coverage changes, and land surface temperature with correlation values − 0.9227, + 0.9489, and − 0.9862 respectively. Even though, the level of impact has not been quantified a conclusion is drawn that urbanization and its impact on climate change have an effect on the positional information of a station.
Engrafting gut bacteriophages have potential to modulate microbial metabolism in fecal microbiota transplantation
Authors: Ji Shuai , Ahmad Freed , Peng Baizhao , Yang Ying , Su Mengting , Zhao Xiaoshan , Vatanen Tommi 
Published: October 2024

Abstract

Background
Fecal microbiota transplantation (FMT) is widely used to treat severe infections and investigated for treatment of complex diseases. The therapeutic efficacy of FMT is related to successful engraftment of bacteriophages from healthy donors to recipients. However, gut bacteriophage contributions to FMT engraftment and treatment outcomes remain unclear.
Methods
The gut phageome from previously published metagenomes of donors and recipients across 23 FMT studies was assembled and functionally annotated for a meta-analysis.
Results
Gut phageome profiles of FMT recipients, especially those with rCDI, shifted towards donor phageomes, accompanied by increasing phageome alpha diversity. Engraftment of donor phages varied between recipient conditions with highest engraftment rate, overrepresented by temperate phage, in patients with rCDI. Consistently, a higher proportion of auxiliary metabolic genes (AMGs), with potential to support and modulate bacterial metabolism, were annotated on temperate phages.
Conclusions
FMT leads to significant taxonomic, functional and lifestyle shifts in recipient phageome composition. Future FMT studies should include gut phageome characterization and consider it as a potential factor in microbial community shifts and treatment outcomes.
Comparison of the sealing ability of the CC sealer and Endoseal MTA sealer by the dye penetration method: A lab-based experimental study
Authors: Modaresi Jalil , Fakhari Nooshin , Shokani Mahdieh 
Published: October 2024

Abstract

Background and Aim: In addition to gutta-percha, different bioceramic materials, such as cold ceramics and MTA, are also used as root-filling materials. Owing to the good sealing properties of bioceramics, in this study, we compared the sealing ability of the CC sealer and Endoseal MTA sealer by the dye penetration method.
Materials and Methods: In this laboratory study, 32 human single-root teeth were used. After canal preparation, the teeth were randomly divided into two equal groups of 13 teeth according to the root canal fillings, which were filled with CC Sealer and Endoseal MTA Sealer via the lateral condensation method. After that, the teeth were stored at 100% humidity and a temperature of 37°C for 10 days. The samples were then stored in normal saline for one month. All the teeth were subsequently dried, and the dental surfaces, with the exception of the apical foramen, were covered with two layers of nail polish. All the samples were immersed in a 2% methylene blue solution for 72 hours. After the teeth were cut longitudinally, the pieces were examined via 20x magnification microscopy.
Results: According to the results of the Mann‒Whitney U test, although the average amount of dye penetration in the CC sealer group, with a value of 1/40 ± 0/64 mm, was less than the average amount of dye penetration in the Endoseal MTA group, with a value of 2/12 ± 1/74 mm, this difference was not statistically significant (P value = 0.418).
Conclusion: Considering the results of the present study and the limitations of laboratory studies, CC sealer and Endoseal MTA sealer seem to have similar sealing abilities. However, the distribution of dye penetration in the Endoseal MTA group was greater than that in the cc sealer group. This can mean that the results are more uniform when the canals are filled with a CC sealer.
Additionally, during the study, CC Sealer presented a longer setting time, which allows it to work better with.
Analyzing the High Frequency of False-Positive Carcinoembryonic Antigen Elevations in Postoperative Pancreatic Ductal Adenocarcinoma
Authors: Tanaka Haruka , Mise Yoshihiro , Takahashi Atsushi , Kawano Fumihiro , Takeda Yoshinori , Imamura Hiroshi , Ichida Hirofumi , Yoshioka Ryuji , Saiura Akio 
Published: October 2024

Abstract

Purpose
The dynamics of postoperative carcinoembryonic antigen (CEA) in pancreatic ductal adenocarcinoma (PDAC) patients have not been well assessed. This study investigated the correlation between postoperative CEA elevations and tumor recurrence.
Methods
Medical records were retrospectively analyzed for 84 patients who received curative resection for PDAC from January 2019 to December 2020. Postoperative CEA levels were monitored for a minimum of 12 months. False-positive CEA elevation was defined as a CEA level exceeding 5 ng/mL without evidence of recurrence in imaging studies.
Results
Of the examined patients, 59 (70%) exhibited CEA > 5 ng/mL within the observation period. The sensitivity and specificity of elevated CEA levels for detecting recurrence were 84% and 41%, respectively. CEA elevations without tumor recurrence were observed in 27 patients, indicating a false-positive rate of 59%. More than half of these patients demonstrated peak CEA levels between 5 and 10 ng/mL, while only true-positive patients exhibited CEA levels exceeding 40.0 ng/mL.
Conclusion
CEA may rise in more than half of postoperative PDAC patients without recurrence. CEA alone is not a robust postoperative marker.
Network Pharmacology and In Silico Approach to Study the Mechanism of Quercetin against Breast Cancer
Authors: SINGH TEJVEER , Rastogi Mahi , Thakur Kulbhushan 
Published: October 2024

Abstract

Breast cancer is one of the dreadful cancers in females, with an estimation of 2.3 million cases globally in 2022. Conventional methods of treatment have now become resistant and cause several adverse effects, due to which there is an urgent need that must be addressed. Thus, these traditional therapies should be replaced with novel drugs. Quercetin is a flavonoid compound which is abundantly reported in vegetables and fruits and displayed to have anti- cancer effects. So, quercetin has the potential to serve as a novel drug to treat breast cancer. Network pharmacology is an integrated technique that considerably aided us in exploring the potential of quercetin as a treatment for breast cancer. The first step in this technique includes target fishing of quercetin targeted genes and breast cancer associated genes through different online databases. An intersecting gene were obtained after removal of redundant data. VarElect analysis is performed to determine phenotypic- genotypic correlation between genes. We performed GO enrichment and pathway enrichment analysis on 52 common genes; followed by PPI network construction and based on topological parameters a top 10 genes are separated. The 8 key targets such as ABCC1, ABCC4, AKT1, ABCB1, CYP1B1, CYP19A1, ABCB4, ABCG2 were retrieved based on these topological parameters through Venny2.1 and then GEPIA and HPA analysis is done. In the end, molecular docking was performed on 8 key genes, and our results claim that quercetin is the potential natural drug that can treat breast cancer effectively and is also appropriate for oral drug intake. Therefore, this study comes to a conclusion that therapeutic influence of quercetin plays a significant role in treating breast cancer and aid in the advancement of clinical application of quercetin in future studies
Training deep learning models on personalized genomic sequences improves variant effect prediction
Authors: Danko Charles , He Adam , Palamuttam Nathan 
Published: October 2024

Abstract

Sequence-to-function models have broad applications in interpreting the molecular impact of genetic variation, yet have been criticized for poor performance in this task. Here we show that training models on functional genomic data with matched personal genomes improves their performance at variant effect prediction. Variant effect representations are retained even when transfer learning models to unseen cellular contexts and experimental readouts. Our results have implications for interpreting trait-associated genetic variation.
Innovative Design of a New Intraosseous-Subperiosteal Combined Implant for Severe Atrophic Edentulous Dentition: A Finite Element Analysis
Authors: Tang Yantai , Nie Huimin , Liu Zhonghao , Zhou Wenjuan 
Published: October 2024

Abstract

Background: To develop a new combined intraosseous-subperiosteal implant for severely atrophic edentulous mandibles and analyze its biomechanical properties via finite element analysis.
Methods: We reconstructed the bone model using CBCT data from a patient with an edentulous mandible. Subsequently, we designed intraosseous implants based on the bone volume within the 3-matic software, and the superstructure abutments were designed on top of it. Then, a subperiosteal titanium mesh base was designed on the surface of the mandible. Finally, the intraosseous implants, the abutments, and the subperiosteal titanium mesh base were integrated to obtain a new intraosseous-subperiosteal combined implant. Four groups of finite element models were assembled, varying in implant design and abutment count. Four loading modes were identified: anterior vertical, unilateral molar vertical, bilateral molar vertical, and unilateral molar lateral occlusions. Finite element analysis was used to analyze the maximum and minimum principal stresses in the peri-implant bone and the von Mises stresses in the implants, abutments, screws, and titanium nails.
Results: A new intraosseous-subperiosteal combined implant for an extremely atrophic edentulous mandible with severe jaw was successfully constructed, which consisted of three main components: a subperiosteal titanium mesh base combining mesh and ribbon morphology, the endosteal implant, and the abutment. The results of finite element analysis demonstrated that the maximum and minimum principal stresses among all groups remained below the yield strength of 140 MPa, while the von Mises stresses in the implant component groups were within the material’s tolerable limits. The surrounding bone stress can be reduced with the novel-designed implant. Increasing the number of abutments can decrease the stress on the implant components.
Conclusions: The new implant developed in this study demonstrated enhanced biomechanical properties in simulated applications for dental implant prosthetics in severely atrophic edentulous mandibles. This innovative design offers a promising alternative for overcoming the challenges associated with dental implant prosthetics in patients with severely atrophic mandibles, potentially improving outcomes in this patient population.
Deep convolutional Neuronal Network for Speech Emotion Recognition
Authors: BOUDIA Mohamed Amine. 
Published: October 2024

Abstract

In recent years, researchers have been investing intensively in the field of AI and robotics so that these robots can communicate as normally as possible with humans. These robots need to recognize human emotions to understand them and respond to their desires. We can recognize the emotion of the person either by his facial expressions, his voice, the gestures of his body or by his words. In this work we just focused on the speech, we worked with the RAVDESS corpus, which contains 8 emotions (neutral, happy, sad, fear, angry, surprise, calm and disgust). For emotion recognition, we have used deep learning which we tested two different architectures based on CNN and compared their accuracies.
Additional benefits of combined ceftriaxone and adipose-derived mesenchymal stem cells on revamping the outcomes in rodent after acute spinal infection
Authors: Yin Tsung-Cheng , Lin Hung-Sheng , Sung Pei-Hsun , Chiang John Y. , Yang Chien-Hui , Yip Hon-Kan , Chen Kuan-Hung 
Published: October 2024

Abstract

This study tested whether combined ceftriaxone and adipose-derived mesenchymal stem cells (ADMSCs) would defend the spinal cord against acute spinal infection (ASI) in rodent. Adult-Male-SD rats were grouped into groups 1 (SC)/2 (ASI)/3 (ASI + ceftriaxone from days 2 to 28 after ASI induction)/4 (ASI + allogenic ADMSCs from day 2 for a total of 3 doses/3 consecutive intervals by intravenous injection)/5 (ASS + combined ceftriaxone and ADMSC) and spinal cord tissues were harvested by day 28. Circulatory levels of TNF-α/IL-6 at days 7 and 28, and these two parameters in spinal fluid at day 28 were lowest in group 1, highest in group 2, significantly lower in group 5 than in groups 3/4, and significantly lower in group 3 than in group 4 (all p < 0.0001). The day-28 bacterial colony formation unit (CFU) in vertebral bone and circulatory WBC counts at the time points of days 7/14/28, and the protein expressions of upstream (TRL-2/TLR-4/MYD88/TRAF6/IKKα/IKKβ /IKBβ/p-NF-κB) and downstream (IL-1β/IL-6/TNF-α/IFN-γ/iNOS) inflammatory signalings displayed a similar pattern of inflammatory biomarkers in spinal fluid among the groups (all p < 0.0001). By day 28, the bone injury score/bone marrow density/ratio of bone volume (BV) to the bone tissue volume (TV)/ratio of bone surface (BS) to BV/ratio of BS to bone TV/trabecular number exhibited an opposite, whereas the trabecular space exhibited an alike pattern of inflammatory biomarkers among the groups (all p < 0.0001). Combined ceftriaxone and ADMSCs therapy offered an additional benefit on protecting the vertebral bone/spinal cord against ASI damage.
Review of Ultrasonic Methods for the Identification of Defects in Epoxy Matrix and Carbon Fiber Composites
Authors: Hernández Melany Isabel Pinilla , Contreras Gastón Sanglier , Fernández Eduardo José Lopez , Tur Sofia Melero , Gonzalez-Lezcano Roberto Alonso 
Published: October 2024

Abstract

Non-Destructive Testing (NDT) methods, and especially, ultrasounds have gone from being a mere laboratory curiosity to an indispensable tool in the industry as a primary means of determining the level of quality achieved in its products (ASM, 1989; Barbero, 1999). This study will identify and apply the main physical phenomena of interaction of an ultrasonic wave in a composite material, to see if through this type of waves, you can detect defects of the type of porosity or delaminations in these materials. The percentages of reflected and transmitted waves in real cases of defects in the composite material will also be studied. It will be shown if the frequencies and intensities of the waves are adequate to find this type of defects or imperfections in the material.The theoretical study of the ultrasonic wave seeks to help researchers in the development of equipment that uses the methodology of immersion ultrasound for the inspection of materials in the search for 'defects' and to understand the physics of the test.
Efficacy of various mulches for modulation of strawberry (Fragaria x ananassa Duch.) yield, quality and shelf life
Authors: Darshan Devi 
Published: October 2024

Abstract

High temperature and low moisture-holing capacity in soil are one of the major constraints for strawberry production under southeastern region, particularly in subtropical climate of Rajasthan. To mitigate these challenges, the current experiment was conducted to examine the impact of different mulching materials on strawberry (Fragaria x ananassaDuch.) cv. Camarosa on yield, quality and shelf life of strawberry fruits under southeastern region of Rajasthan. The application of black polyethylene mulch significantly improved the plant height, the number of leaves per plant, number of stolon’s per plant, berry weight, berry length, berry width, soluble solid content, TSS: acid ratio, juice content, vitamin C, reducing sugar, non-reducing sugar, total sugars, anthocyanin, as well as leaf nitrogen, leaf phosphorus, leaf potassium content. It also resulted low acidity compared to control. On the other hand the use of wheat straw reduced weight loss, and fruit spoilage, while enhancing the shelf life of fruits as compared to black polyethylene mulch. Hence, it can be concluded from the present investigation that the application of black polyethylene mulch significantly improved the vegetative growth, physio-chemical properties and leaf nutrients composition of strawberry plants followed by silver black polyethylene mulch. Meanwhile, organic mulches (wheat straw & paddy straw) significantly reduced the weight loss, minimized fruit spoilage and improved the shelf life of the fruits.