bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved antioxidant properties and sustainability of whole‐fruit yellow tomato puree
Authors: Pizzolongo Fabiana , Sorrentino Giovanni , Graci Salvatore , Barone Amalia , Romano Raffaele 
Published: September 2024

SummaryIn this study, a new process was proposed to make the yellow tomato puree more sustainable, avoiding any waste during production and including peels and seeds in it. In addition, as raw material tomatoes grown without irrigation and fertilisation procedures were used to increase the sustainability. With respect to a traditional puree, the whole‐fruit yellow tomato puree contained more β‐carotene and polyphenols, exhibiting greater antioxidant capacity, and showed greater consistency due to the high content of pectin in peels. Moreover, a higher content of glutamic acid, responsible for the umami taste, was detected particularly in products from GiaGiù ecotype. Sensory analysis assessed that whole‐fruit yellow tomato puree has good acceptability and consumers preferred it for the texture. In conclusion, the whole‐fruit yellow tomato puree is not only a sustainable product but can be also used as an excellent ingredient in food formulation with antioxidant properties.
Improving physicochemical and biological properties of gelatin‐xylooligosaccharide conjugates by Maillard reaction
Authors: Li Huiyu , Xiong Tao , Du Tonghao , Huang Siyun , Peng Fei 
Published: September 2024

SummaryMaillard reaction can enhance the functional characteristics of the protein. Herein, we investigated changes in the physicochemical and biological properties of gelatin (GA)‐xylooligosaccharide (XOS) conjugates following Maillard reaction. The results showed that the browning intensity of the conjugates increased with the prolongation of heating time. Additionally, sodium dodecyl sulphate‐polyacrylamide gel electrophoresis revealed some macromolecule polymer formed, and the grafting degree of GA was augmented to 40.05% with prolongation of heating time. GA glycation with XOS decreased α‐Helix content and increased level of β‐Turn level, and exerted a slight impact on contact angle. Moreover, the results of in vitro simulated gastrointestinal digestion analysis showed that the GA‐XOS mixture enhanced resistance to digestion after Maillard reaction for 60 min, affording hydrolysis ratios ranging from 17.86–27.79% and 25.03–35.47% in simulated gastric fluid and intestinal fluid, respectively. The antioxidant ability and heat stability of the conjugates was visibly enhanced following heating treatment. Additionally, increasing the mass of XOS accelerated the antioxidant capacities of GA‐XOS conjugates. The finding will assist the fabrication of GA‐XOS conjugates with highly functional properties by Maillard reaction.
Comparisons of healthcare personnel relating to awareness, concern, motivation, and behaviours of climate and health: A cross‐sectional study
Authors: Rangel Teresa , Johnson Sarah E. , Joubert Patricia , Timmerman Rosemary , Smith Stephan , Springer Gale , Schenk Elizabeth 
Published: September 2024

AbstractAim(s)To describe a sample of healthcare professionals' responses to the valid and reliable Climate and Health Tool and compare participant characteristics relating to Climate and Health Tool subscales.DesignObservational, cross‐sectional, multi‐site study.MethodsAn electronic survey containing the Climate and Health Tool was administered to healthcare professionals across a large, multi‐state health system in the Western United States with a committed effort to reducing carbon emissions.ResultsOne thousand three hundred and sixty‐three participants reported moderately elevated levels of awareness and concern around climate impacts on health and motivation to participate in climate protective actions. Respondents reported moderate levels of climate‐protecting behaviours at home and low levels at work. Females were more concerned and motivated. Medical staff and respondents reporting familiarity with system environmental initiatives reported more awareness and behaviours at home to preserve climate health.ConclusionHealthcare professionals are concerned and motivated to decrease climate impacts on health yet take little action at work to preserve the climate. Because of the intersection of climate change, health, and healthcare, healthcare organizations should prioritize and support meaningful action for healthcare professionals to meet community climate health needs.Implications for the Profession and/or Patient CareHealthcare organizations committed to contributing to climate solutions can use this research to increase healthcare professionals' education, engagement, and impact to preserve the climate and health of communities.Impact

Healthcare is a major contributor to carbon emissions, yet healthcare professionals' awareness, motivation, concern, and behaviours related to climate change and health were not clear.

Our research showed healthcare professionals are aware and concerned about climate impacts on health but reported low levels of workplace behaviours to protect the climate.

The findings of our research will impact healthcare professionals and healthcare organizations to focus efforts on climate‐preserving behaviours.

Reporting MethodThis manuscript followed the STROBE guidelines.Patient or Public ContributionNone.
Quantifying the Capacity for Assisted Migration to Achieve Conservation and Forestry Goals Under Climate Change
Authors: Zou Yibiao , Backus Gregory A. , Safford Hugh D. , Sawyer Sarah , Baskett Marissa L. 
Published: September 2024

ABSTRACTAimMany tree species may be threatened with declines in range and biomass, or even extinction, if they cannot disperse or adapt quickly enough to keep pace with climate change. One potential, and potentially risky, strategy to mitigate this threat is assisted migration (AM), the intentional movement of species to facilitate population range shifts to more climatically suitable locations under climate change. The ability for AM to minimise risk and maximise conservation and forestry outcomes depends on a multi‐faceted decision process for determining, what, where and how much to move. We provide an assessment on how the benefits and risks of AM could affect the decision‐making process.LocationMountainous coastal western United States.TaxonTrees.MethodsWe used a dynamic vegetation model parameterised with 23 tree species.ResultsWe found that most of the modelled species are likely to experience a substantial decline in biomass, with many potentially facing regional extinction by 2100 under the high‐emission SSP5‐85 climate‐change scenario. Though simulations show AM had little effect on the forestry goal of total biomass across all species, its effects on the conservation goal of promoting individual species' persistence were far more substantial. Among eight AM strategies (differing in the life cycle stage of movement and target destination selection criteria), the approach that conserved the highest biomass for individual species involved relocating target seedlings to areas that recently experienced fire. Although this strategy significantly reduced extinction risk for six at‐risk species compared with no action, it also slightly reduced biomass of four species, due to increasing competition. Species with relatively weak tolerance to drought, fire or high temperature were the most likely candidate groups for AM.Main ConclusionsOur simulations indicate that AM can aid conservation by reducing extinction risks for species vulnerable to climate change, but it has limited impact on forestry‐specific goals, affecting overall biomass minimally. This model framework could be applied to other forest ecosystems to evaluate the efficacy of AM globally.
Synthesis of 6‐bromo‐7‐arylaminoisoquinoline‐5,8‐quinones and its effects on Piscirickettsia salmonis infection in vitro
Authors: Ibacache Juana A. , Espinoza Mario , Basualto‐Díaz Paz , Pinto Victoria , Modak Brenda , Zapata Paula , Valenzuela Beatriz 
Published: September 2024

AbstractAmong the most important aquaculture resources for our country, salmon and trout stand out. Their production has increased significantly in recent decades, making them two of the most valuable resources in economic terms. However, high aquaculture production has allowed many pathogens to proliferate, causing infectious diseases and significant production losses. Piscirickettsia salmonis is a gram‐negative, facultative intracellular bacterium that is responsible for causing severe disease in a variety of salmonid fish species. Despite the significant impact of P. salmonis on aquaculture, effective treatments for this disease remain limited. Current prevention and control strategies often include antibiotics and vaccines. However, these treatments have shown varying degrees of efficacy. A promising approach involves synthesizing bioactive analog compounds with antibacterial properties. Quinones, secondary metabolites that are abundant in nature, have become a focal point of interest due to their diverse physiological activities, including antibiotic, insecticidal, antifungal, and anticancer properties. In this study, it is shown the synthesis of series 6‐bromo‐7‐arylaminoisoquinoline‐5,8‐quinones, the characterization of these compounds using classical spectroscopic methods such as one‐dimensional nuclear magnetic resonance (NMR), FT‐IR (infrared), mass spectrometry, and the biological activity against Piscirickettsia salmonis. The brominated derivative compounds showed no cytotoxicity at any concentration evaluated. Furthermore, the infectivity of P. salmonis after treatment with the analog compounds indicated that derivatives methyl 6‐bromo‐7‐((4‐methoxyphenyl)amino)‐1,3‐dimethy‐5,8‐dioxo‐5,8‐dihydroisoquinoline‐4‐carboxylate (4b) and methyl 7‐((4′‐amino‐[1,1′‐biphenyl]‐4‐yl)amino)‐6‐bromo‐1,3‐dimethy‐5,8‐dioxo‐5,8‐dihydroisoquinoline‐4‐carboxylate (4g) reduced the bacterial load at 25 μg/mL concentration.
PRRT in high‐grade digestive neuroendocrine neoplasms (NET G3 and NEC)
Authors: Sorbye Halfdan , Kong Grace , Grozinsky‐Glasberg Simona , Strosberg Jonathan 
Published: September 2024

AbstractPeptide receptor radionuclide therapy (PRRT) has been primarily studied in low and intermediate‐grade digestive neuroendocrine tumors (NET G1‐G2). The documentation of a similar benefit for high‐grade digestive neuroendocrine neoplasms (NEN) has been limited. This review evaluates the use of PRRT for high‐grade digestive NEN (well‐differentiated NET G3 and poorly differentiated neuroendocrine carcinomas [NEC]). We identified one phase III trial and seven retrospective studies reporting specifically on PRRT outcome of >10 digestive high‐grade NEN patients. The retrospective single‐arm studies indicate a benefit for PRRT in NET G3. The randomized phase III NETTER‐2 trial demonstrates major PFS superiority of PRRT versus somatostatin analog therapy as the first‐line treatment for the NET G3 subgroup. PRRT can now be considered a potential first‐line treatment for somatostatin receptor‐positive NET G3 patients, but whether it should be the first‐line standard of care for all NET G3 patients is still not clarified. For NEC, scarce data are available, and pathologic distinction between NEC and NET G3 can be difficult when Ki‐67 is below 55%. PRRT could be considered as a treatment for refractory NEC in very selected cases when there is a high uptake on somatostatin receptor imaging, Ki‐67 is below 55%, and there is no rapid tumor progression.
Help‐Seeking Needs Related to Suicide Prevention for Individuals in Contact With Mental Health Services: A Rapid Scoping Review
Authors: Shin Hwayeon Danielle , Kemp Jessica , Groves Samantha , Bennett‐Poynter Laura , Pape Charlotte , Lascelles Karen , Strudwick Gillian 
Published: September 2024

ABSTRACTIntroductionPrior mental healthcare utilisation presents an important window of opportunity for providing suicide prevention interventions. To date, no reviews have consolidated the help‐seeking needs of individuals in contact with mental health services. This warrants further attention given this group may have different needs for interventions compared with the general population who have not sought help previously.AimThe purpose of this rapid scoping review was to summarise the available literature on help‐seeking needs related to suicide prevention among individuals in contact with mental health services from healthcare settings.MethodCochrane rapid review and Joanna Briggs Institute scoping review methodologies were adapted, and databases, including MEDLINE, Scopus, CINAHL, PsycInfo and EMBASE, were searched.ResultsA total of 42 primary studies were included in analysis. Reported barriers and facilitators to help‐seeking behaviours identified within studies were mapped onto the socio‐ecological model. Barriers and facilitators identified included knowledge and attitudes towards healthcare utilisation, family and peer support, interactions with healthcare professionals, provision of holistic care, and the creation of a supportive atmosphere and safe space to promote open discussions of suicide‐related concerns.DiscussionThe findings of this review offer valuable insights into areas for improvement in addressing help‐seeking needs for individuals who are in contact with health services related to suicide prevention.Implication for ResearchThe findings serve as a foundation for shaping mental health initiatives informing approaches and care delivery tailored towards individuals who are in contact with health services. The reported barriers and facilitators offer insights to inform the development of mental health support tools to enhance care and considerations for evaluations.
O le Fau Gagana: A Samoan Mental Health Nurse in Aotearoa‐New Zealand
Authors: Mulipola Taavale Ioana 
Published: September 2024

ABSTRACTIntroductionThis article explores my journey as a Samoan woman who migrated as a young mother to Aotearoa‐New Zealand, completed nursing qualifications, later specialising in mental health nursing, and eventually completed doctoral studies. Since July 2023 I have been a Lecturer in the Department of Nursing, Faculty of Health and Environmental Studies, Auckland University of Technology.MethodsThis article uses autoethnographic and narrative methods to collect data from my own life, to explore the experiences of Samoan people in the mental health system of Aotearoa‐New Zealand. Criteria for reporting qualitative research was used to prepare the paper.FindingsMy story showcases the benefits of having both clinical and cultural understandings in the context of mental health care in Aotearoa‐New Zealand. The gap between the rhetoric and the reality of the ‘New Zealand dream’ for Samoan people mirrors the gap between policy and practice in relation to Pacific strategy plans for mental health care.ConclusionsBy writing about my experiences, I aim to support better understanding of core concerns for Samoan people when they are engaging with mental healthcare services.
Transcriptomic and functional analyses on a Botrytis cinerea multidrug‐resistant (MDR) strain provides new insights into the potential molecular mechanisms of MDR and fitness
Authors: Sofianos Georgios , Piombo Edoardo , Dubey Mukesh , Karlsson Magnus , Karaoglanidis George , Tzelepis Georgios 
Published: September 2024

AbstractBotrytis cinerea is a notorious pathogen causing pre‐ and post‐harvest spoilage in many economically important crops. Excessive application of site‐specific fungicides to control the pathogen has led to the selection of strains possessing target site alterations associated with resistance to these fungicides and/or strains overexpressing efflux transporters associated with multidrug resistance (MDR). MDR in B. cinerea has been correlated with the overexpression of atrB and mfsM2, encoding an ATP‐binding cassette (ABC) and a major facilitator superfamily (MFS) transporter, respectively. However, it remains unknown whether other transporters may also contribute to the MDR phenotype. In the current study, the transcriptome of a B. cinerea multidrug‐resistant (MDR) field strain was analysed upon exposure to the fungicide fludioxonil, and compared to the B05.10 reference strain. The transcriptome of this field strain displayed significant differences as compared to B05.10, including genes involved in sugar membrane transport, toxin production and virulence. Among the induced genes in the field strain, even before exposure to fludioxonil, were several putatively encoding ABC and MFS transmembrane transporters. Overexpression of a highly induced MFS transporter gene in the B05.10 strain led to an increased tolerance to the fungicides fluopyram and boscalid, indicating an involvement in efflux transport of these compounds. Overall, the data from this study give insights towards better understanding the molecular mechanisms involved in MDR and fitness cost, contributing to the development of more efficient control strategies against this pathogen.
Impact of single centre kidney‐exchange transplantation to increase living donor pool in India: A cohort study involving non‐anonymous allocation
Authors: Kute Vivek B. , Patel Himanshu V. , Banerjee Subho , Engineer Divyesh P. , Dave Ruchir B. , Shah Nauka , Chauhan Sanshriti , Meshram Harishankar , Tambi Priyash , Shah Akash , Saxena Khushboo , Balwani Manish , Parmar Vishal , Shah Shivam , Prakash Ved , Patel Sudeep , Patel Dev , Desai Sudeep , Rizvi Jamal , Patel Harsh , Parikh Beena , Kanodia Kamal , Gandhi Shruti , Rees Michael A. , Roth Alvin E. , Modi Pranjal 
Published: September 2024

AbstractAimIn India, 85% of organ donations are from living donors and 15% are from deceased donors. One‐third of living donors were rejected because of ABO or HLA incompatibility. Kidney exchange transplantation (KET) is a cost‐effective and legal strategy to increase living donor kidney transplantation (LDKT) by 25%–35%.MethodsWe report our experience with 539 KET cases and the evolution of a single‐centre program to increase the use of LDKT.ResultsBetween January 2000 and 13 March, 2024, 1382 deceased donor kidney transplantations and 5346 LDKT were performed at our centre, including 10% (n = 539) from KET. Of the 539 KET, 80.9% (n = 436) were ABO incompatible pairs, 11.1% (n = 60) were compatible pairs, and 8% (n = 43) were sensitized pairs. There were 75% 2‐way (n = 2 × 202 = 404), 16.2% 3‐way (n = 3 × 29 = 87), 3% 4‐way (n = 4 × 4 = 16), 1.8% 5‐way (n = 5 × 2 = 10), 2.2% 6‐way (n = 6 × 2 = 12), and 1.8% 10‐way KET (n = 10 × 1 = 10). Of the recipients 81.2% (n = 438) were male and 18.8% (n = 101) were female, while of the donors, 78.5% (n = 423) were female and 21.5% (n = 116) were male. All donors were near relatives; wives (54%, n = 291) and mothers (20%, n = 108) were the most common donors. At a median follow‐up of 8.2 years, patient survival, death censored graft survival, acute rejection, and median serum creatinine levels of functioning grafts were 81.63% (n = 440), 91% (n = 494), 9.8% (n = 53) and 1.3 mg/dL respectively. We credited the success to maintaining a registry of incompatible pairs, high‐volume LDKT programs, non‐anonymous allocation and teamwork.ConclusionThis is the largest single‐centre KET program in Asia. We report the challenges and solutions to replicate our success in other KET programs.image
Impact of maxillary expansion on the sagittal skeletal and dental parameters of growing Class II patients: A systematic review with meta‐analysis
Authors: Cannatà Davide , Galdi Marzio , Scelza Carmine , Simeon Vittorio , Giordano Francesco , Martina Stefano 
Published: September 2024

AbstractA “spontaneous” correction of the Class II malocclusion has been described after maxillary expansion (ME) treatment. The aim of the present review was to systematically summarize changes in the sagittal dentoskeletal parameters of growing Class II patients after ME. The study protocol was developed according to the PRISMA statement and registered in PROSPERO before literature search, data extraction and analysis. The PICO model was followed in the definition of the research question, search strategies and study selection criteria. Randomized and non‐randomized studies on the sagittal effects of ME published in English language without date restrictions were electronically searched across the Cochrane Library, Scopus and MEDLINE/PubMed databases. Changes in sagittal dentoskeletal cephalometric parameters were analysed. The risk of bias in randomized and nonrandomized studies was assessed using the Rob2 and ROBINS‐I tools, respectively. A narrative synthesis was performed, focusing on the investigated population, intervention, comparison, and main outcomes. Pairwise meta‐analyses were used to compare the outcomes assessed in subjects who underwent ME versus untreated subjects. Ten studies met the inclusion criteria, four were included in the pairwise meta‐analyses due to the presence of a control group. Slight but significant improvements in OVJ (MD: −0.36; 95%; CI [−0.69 to −0.01]; p = .04) and 6/6 molar relation (MD: 1.5; 95%; CI [0.69 to 1.61]; p < .0001) were found in patients who underwent ME compared with untreated subjects, whereas no improvement in skeletal parameters was observed. However, the limitations of a small body of moderate‐quality evidence and possible confounding factors should be considered. Evidence on the sagittal skeletal and dental effects of ME in Class II patients is still ambiguous, suggesting the need for more clinical trials, including appropriate control subjects, randomization and blinding during outcome assessment.
Accuracy of measurements on CBCT‐generated digital models using different exposure parameters (in vitro study)
Authors: Ibrahim Noura , Abouelkheir Hassan Mohamed , Elkersh Noha Mohamed 
Published: September 2024

AbstractIntroductionDental imaging comprises a wide range of techniques and modalities, each with different diagnostic features influenced by numerous parameters, all of which contribute to the precision and effectiveness of dental evaluations and treatments. This study examined the dimensional reproducibility of arch measurements from CBCT scans with different voxel sizes and exposure parameters compared to a reference model from Extra‐oral scanners (EOS) and how these parameters affected digital matching and diagnostic image quality.MethodsA diagnostic observational study of arch dimensions, including inter‐canine, inter‐premolar, intermolar, arch width and arch length, was conducted on digital models (DMs) created from 65 CBCT scans of a full dentate epoxy maxillary model. The measurements obtained from EOS scans served as the control for the study. Normality was tested with the Shapiro–Wilk test, comparisons used the Kruskal–Wallis test with Bonferroni‐adjusted pairwise comparisons for significant results, and data were analysed using IBM SPSS (Version 26.0), with significance set at p < .05.ResultsSignificant deviations were revealed among study groups, with group I (smallest voxel size) consistently displaying the lowest values, mean (SD) deviation was reported as 0.01 (0.006) and group IV (lowest kV value) exhibiting the highest deviations, mean (SD) deviation of 0.16 (0.17).ConclusionCombining a small voxel size (0.12 mm) with high milliampere (8 mA) and kilovoltage (90 kV) settings in CBCT ensured detailed anatomical visualization and accurate linear measurements, crucial for precise dental assessments, and emphasizing the necessity for strict control over CBCT parameters in dental applications.