bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Worker’s Help in Restoring Human Dignity
Authors: Virbalienė Akvilė 
Published: December 2015

Abstract
In this article are presented situations in which the feeling of dignity of a person is lost or decreases and cannot be restored without professional intervention. This loss is one of the reasons of social exclusion in communities. A person with social issues has no abilities to emphasize her/his own uniqueness and authenticity, s/he stops to progress physically, intellectually and spiritually. In this way these persons enter the field of social worker’s help. In this field of help, one of the main factors in the restoration of human dignity is the social worker her/himself: her/his personality can have a huge influence on his client. The main research question in this study is the following: How should a social worker construct the helping process to help the client to restore her/his human dignity? Research object was the social worker’s help in the process of the restoration of human dignity. Research aim was to reveal the elements of the social worker’s support process that help to restore human dignity. Analysis of the reseach-based conceptual literature was the core method to explore and reveal the answers to research questions. The findings of the analysis highlighted that in situations, when people loose their feeling of dignity within social exclusion then they experience the self-deprecating. In the process of social help a main role is played by social worker’s professional communication with the client: the social worker stimulates the maintenance and restoration of client’s dignity by applying the principle of acting together. This principle is based on moral values, reciprocal responsibility, mutual respect, sincerity, confidentiality and empathy. These components create a trustful environment where, by sustaining client’s free choice and a right of decision, the possibility to achieve client’s openness emerges.
Epidemiological Review of Kidney Biopsy during 30 years - Single Center Experience
Authors: Jankovic Aleksandar , Ikonomovski Jovan , Djuric Petar , Mitrovic Milos , Tosic- Dragovic Jelena , Bulatovic Ana , Lipkovski-Markovic Jasmina , Basta-Jovanovic Gordana , Vujic Danica , Dimkovic Nada 
Published: December 2015

Abstract
Introduction. Renal biopsy represents a diagnostic method that provides an acurrate diagnosis and adequate treatment of different renal diseases. The first biopsy in our Center was done in June 1982, but it has been performing routinely since 1984. The aim of this study was to report the histopathological features of biopsy proven kidney disease during the past 30 years.
Methods. During 30 years, a total of 563 biopsies were performed, of which 530(94%) were succesfull. Data about gender, age, clinical syndrome and histopatological finding were collected from the medical records.
Results. The mean age of our patients was 48±11 years, 53% were man (No=272). In the first decade (1982-1994) we performed 118(mean age 50±13), in the second (1995- 2004) 208 (mean age 46±14), and in the third decade (2005-2014) 189 renal biopsies (mean age 50±16). Mean number of glomeruli per biopsy was 18±11. There were only two serious complications. The most common clinical syndromes as indication for renal biopsy were: nephrotic proteinuria (41%) followed by asymptomatic urinary abnormalities (AUA-14.8%), chronic renal failure (CRF-13.8%), acute kidney injury (AKI-12.8%), nephritic syndrome (7.6%), systemic lupus erytematosus (SLE- 4.5%), isolated haematuria (2.7% of the cases) and other (2.9%). The major histological groups identified were: primary glomerulonephritis (GN) (62.3%), secondary GN (21.2%), and other (16.5% of the cases). The most common primary glomerulonephritis (PGN) were focal segmental glomerulosclerosis-FSGS (19.4%) followed by IgA nephropathy-IgAN (18.8%), membranous GNMGN (16.4%) and mesangial proliferation-MesGN (16%). Interstitial changes were present in 55% of biopsy samples in the first, in 66% in the second and in 63% in the third decade. Blood vessel changes were present in 39% of biopsy samples in the first, in 62% in the second and in 72% in the third decade.
Conclusions. The most frequent finding among PGN was mesangioproliferative GN (including IgAN, alltogether 34.8%) followed by FSGS and MGN. Apart from succesful biopsies, there are several aspects to be improved in the future including expanding indications and earlier procedure during the course of chronic kidney disease-CKD.
Contrast Induced Nephropathy in Patients with Acute Coronary Syndrome
Authors: Ugur Mehmet Can , Ekinci Ferhat , Soyaltın Utku Erdem , Akar Harun 
Published: December 2015

Abstract
Introduction. Contrast-induced nephropathy (CIN) is associated with increased morbidity and mortality after percutaneous coronary intervention (PCI). On the other hand, CIN is a serious complication in patients with diabetes or renal impairment undergoing percutaneous coronary intervention (PCI). CIN after PCI may be associated with prolonged hospitalization, increased rates of kidney injury, and short- and long-term mortality. Factors that have been associated with CIN include: diabetes mellitus, congestive heart failure, recent acute myfocardial infarction, cardiogenic shock, and pre-existing renal impairment. In this study, we investigated contrast nephropathy development after coronary angiography (CAG) in patients presenting with acute coronary syndrome, who were hospitalized initially in the Coronary Care Unit and subsequenttly referred to the Internal Medicine Clinic in a tertiary care hospital.
Methods. We’ve analyzed 335 patients’ records retrospectively in 1 year that were followed-up with acute coronary syndrome (ACS) in the Coronary Care Unit (CCU) and transferred to the Internal Medicine Clinic (IMC). The following parameters were evaluated: age, gender, chronic disease and drug history, biochemical values evaluated before hospitalization to CCU, ejection fraction (EF) and left atrium diameter (LA), with or without previous CAG; values of serum creatinine (sCr) levels before CAG and after 48 hours. Values of p <0.05 were considered to be significant.
Results. 126 of 335 patients were female and 209 were male. The average age of patients was 64.2 years. 122 patients used angiotensin converting enzyme inhibitor (ACEI), 54 patients used furosemide. CIN development rate of CAG patients was 22.8% (n=54). There was no significant relationship with age, gender and chronic disease history in CIN patients. When laboratory findings were compared, there was no significant relationship except for potassium value before CAG. However, potassium values were significantly higher in CIN patients (p=0.001). When drug usage of patients was compared, 48.1% (n=26) of CIN patients used ACEI and there was a significant relationship between ACEI use and CIN development (p=0.026).
Conclusions. CIN development rate was 22.8% and it was relatively high when compared with literature data. Awareness about contrast nephropathy develepment risk and assessment of risk factors before the procedure should be increased in our Center.
Analytical interference by monoclonal immunoglobulins on the direct bilirubin AU Beckman Coulter assay: the benefit of unsuspected diagnosis from spurious results
Authors: García-González Elena , González-Tarancón Ricardo , Aramendía Maite , Rello Luis 
Published: December 2015

AbstractMonoclonal (M) components can interfere with the direct bilirubin (D-Bil) assay on the AU Beckman Coulter instrumentation and produce spurious results, such as D-Bil values greater than total bilirubin (T-Bil) or very low/negative D-Bil values. If properly detected, this interference may uncover undiagnosed patients with monoclonal gammopathy (MG).We investigated the interference rate on the D-Bil AU assay in serum samples known to contain M proteins along with their isotype and described the protocol set up in our laboratory to help with the diagnosis of MG based on D-Bil spurious results as first indication.During a period of 4 years, 15.4% (345 of 2235) of serum samples containing M immunoglobulins produced erroneous D-Bil results, although no clear relationship between the magnitude or isotype of the M component and interference could be found. In total 22 new patients were diagnosed with MG based on the analytical artefact with the D-Bil as first indication.The D-Bil interference from MG on the Beckman AU analysers needs to be made known to laboratories in order to prevent clinical confusion and/or additional workup to explain the origin of anomalous results. Although this information may not add to the management of existing patients with serum paraproteins, it can benefit patients that have not been diagnosed with MG by triggering follow up testing to determine if M components are present.
Neonatal morbidities and need for intervention in twins and singletons born at 34–35 weeks of gestation
Authors: Simchen Michal J. , Okrent Smolar Avital L. , Dulitzky Mordechai , Sivan Eyal , Morag Iris 
Published: December 2015

Abstract

Objective:
To compare indications for delivery and neonatal morbidities between twins and singletons born between 34 and 35 weeks of gestation.

Study design:
A prospective observational study was performed in which all infants born between January and August 2008, at Sheba Medical Center at 34 0/7–35 6/7 weeks of gestational age were included. Indications for delivery, infants’ morbidities and medical interventions were documented. Twins and singletons were compared for antenatal maternal characteristics, risks of short-term neonatal complications and interventions.

Results:
One hundred and seventy-three mothers and 229 neonates (114 twins and 115 singletons) were included. Background maternal characteristics as well as the use of antenatal steroids and MgSO4 were similar between the groups. Only 44% of all deliveries were spontaneous, while the rest were indicated deliveries. Twins were born lighter and 31.9% of them were SGA. Nevertheless, singletons were significantly more likely to receive medical interventions such as prolonged oxygen use (>1 day) and phototherapy. All late preterm infants (n=5) needing surfactant administration were singletons. Overall, the risk of needing any medical intervention was significantly higher for singletons compared with twins (OR 1.8, 95% CI 1.02–3.2).

Conclusions:
A significant proportion of late preterm births is iatrogenic. Twins and singletons are dissimilar with regards to risks of short-term complications. Despite being born smaller and more SGA, twins are at lower risk of requiring medical intervention in the immediate neonatal period compared with singletons.
Ball Speed and Release Consistency Predict Pitching Success in Major League Baseball
Authors: Whiteside David , Martini Douglas N. , Zernicke Ronald F. , Goulet Grant C. 
Published: December 2015

Abstract
Whiteside, D, Martini, DN, Zernicke, RF, and Goulet, GC. Ball speed and release consistency predict pitching success in Major League Baseball. J Strength Cond Res XX(X): 000–000, 2015—This study aimed to quantify how ball flight kinematics (i.e., ball speed and movement), release location, and variations therein relate to pitching success in Major League Baseball (MLB). One hundred ninety starting MLB pitchers met the inclusion criteria for this study. Ball trajectory information was collected for 76,000 pitches and inserted into a forward stepwise multiple regression model, which examined how (a) pitch selection, (b) ball speed, (c) ball movement (horizontal and lateral), (d) release location (horizontal and lateral), (e) variation in pitch speed, (f) variation in ball movement, and (g) variation in release location related to pitching success (as measured by fielding independent pitching—FIP). Pitch speed, release location variability, variation in pitch speed, and horizontal release location were significant predictors of FIP and, collectively, accounted for 24% of the variance in FIP. These findings suggest that (a) maximizing ball speed, (b) refining a consistent spatial release location, and (c) using varied pitch speeds should be primary foci for the pitching coach. However, between-pitcher variations underline how training interventions should be administered at the individual level, with consideration given to the pitcher's injury history. Finally, despite offering significant predictors of success, these three factors explained only 22% of the variance in FIP and should not be considered the only, or preeminent, indicators of a pitcher's effectiveness. Evidently, traditional pitching metrics only partly account for a pitcher's effectiveness, and future research is necessary to uncover the remaining contributors to success.
Wearable Lactate Threshold Predicting Device is Valid and Reliable in Runners
Authors: Borges Nattai R. , Driller Matthew W. 
Published: December 2015

Abstract
Borges, NR and Driller, MW. Wearable lactate threshold predicting device is valid and reliable in runners. J Strength Cond Res 30(8): 2212–2218, 2016—A commercially available device claiming to be the world's first wearable lactate threshold predicting device (WLT), using near-infrared LED technology, has entered the market. The aim of this study was to determine the levels of agreement between the WLT-derived lactate threshold workload and traditional methods of lactate threshold (LT) calculation and the interdevice and intradevice reliability of the WLT. Fourteen (7 male, 7 female; mean ± SD; age: 18–45 years, height: 169 ± 9 cm, mass: 67 ± 13 kg, V̇o
2max: 53 ± 9 ml·kg−1·min−1) subjects ranging from recreationally active to highly trained athletes completed an incremental exercise test to exhaustion on a treadmill. Blood lactate samples were taken at the end of each 3-minute stage during the test to determine lactate threshold using 5 traditional methods from blood lactate analysis which were then compared against the WLT predicted value. In a subset of the population (n = 12), repeat trials were performed to determine both inter-reliability and intrareliability of the WLT device. Intraclass correlation coefficient (ICC) found high to very high agreement between the WLT and traditional methods (ICC > 0.80), with TEMs and mean differences ranging between 3.9–10.2% and 1.3–9.4%. Both interdevice and intradevice reliability resulted in highly reproducible and comparable results (CV < 1.2%, TEM <0.2 km·h−1, ICC > 0.97). This study suggests that the WLT is a practical, reliable, and noninvasive tool for use in predicting LT in runners.
Neuromuscular Adaptations After 2 and 4 Weeks of 80% Versus 30% 1 Repetition Maximum Resistance Training to Failure
Authors: Jenkins Nathaniel D.M. , Housh Terry J. , Buckner Samuel L. , Bergstrom Haley C. , Cochrane Kristen C. , Hill Ethan C. , Smith Cory M. , Schmidt Richard J. , Johnson Glen O. , Cramer Joel T. 
Published: December 2015

Abstract
Jenkins, NDM, Housh, TJ, Buckner, SL, Bergstrom, HC, Cochrane, KC, Hill, EC, Smith, CM, Schmidt, RJ, Johnson, GO, and Cramer, JT. Neuromuscular adaptations after 2 and 4 weeks of 80% versus 30% 1 repetition maximum resistance training to failure. J Strength Cond Res 30(8): 2174–2185, 2016—The purpose of this study was to investigate the hypertrophic, strength, and neuromuscular adaptations to 2 and 4 weeks of resistance training at 80 vs. 30% 1 repetition maximum (1RM) in untrained men. Fifteen untrained men (mean ± SD; age = 21.7 ± 2.4 years; weight = 84.7 ± 23.5 kg) were randomly assigned to either a high-load (n = 7) or low-load (n = 8) resistance training group and completed forearm flexion resistance training to failure 3 times per week for 4 weeks. Forearm flexor muscle thickness (MT) and echo intensity, maximal voluntary isometric (MVIC) and 1RM strength, and the electromyographic, mechanomyographic (MMG), and percent voluntary activation (%VA) responses at 10–100% of MVIC were determined at baseline, 2, and 4 weeks of training. The MT increased from baseline (2.9 ± 0.1 cm) to week 2 (3.0 ± 0.1 cm) and to week 4 (3.1 ± 0.1 cm) for the 80 and 30% 1RM groups. MVIC increased from week 2 (121.5 ± 19.1 Nm) to week 4 (138.6 ± 22.1 Nm) and 1RM increased from baseline (16.7 ± 1.6 kg) to weeks 2 and 4 (19.2 ± 1.9 and 20.5 ± 1.8 kg) in the 80% 1RM group only. The MMG amplitude at 80 and 90% MVIC decreased from baseline to week 4, and %VA increased at 20 and 30% MVIC for both groups. Resistance training to failure at 80 vs. 30% 1RM elicited similar muscle hypertrophy, but only 80% 1RM increased muscle strength. However, these disparate strength adaptations were difficult to explain with neuromuscular adaptations because they were subtle and similar for the 80 and 30% 1RM groups.
Contraceptive Provision to Adolescent Females Prescribed Teratogenic Medications
Authors: Stancil Stephani L. , Miller Melissa , Briggs Holley , Lynch Daryl , Goggin Kathy , Kearns Gregory 
Published: December 2015

BACKGROUND AND OBJECTIVES:
Rates of adult women receiving contraceptive provision when simultaneously prescribed a known teratogen are alarmingly low. The prevalence of this behavior among pediatric providers and their adolescent patients is unknown. The objective of this study was to describe pediatric provider behaviors for prescribing teratogens concurrently with counseling, referral, and/or prescribing of contraception (collectively called contraceptive provision) in the adolescent population.

METHODS:
A retrospective review was conducted examining visits in 2008–2012 by adolescents aged 14 to 25 years in which a known teratogen (US Food and Drug Administration pregnancy risk category D or X) was prescribed. The electronic medical records were queried for demographic information, evidence of contraceptive provision, and menstrual and sexual histories. The data were analyzed using standard statistical methods.

RESULTS:
Within 4172 clinic visits, 1694 females received 4506 prescriptions for teratogenic medications. The most commonly prescribed teratogens were topiramate, methotrexate, diazepam, isotretinoin, and enalapril. The subspecialties prescribing teratogens most frequently were neurology, hematology-oncology, and dermatology. Overall, contraceptive provision was documented in 28.6% of the visits. Whites versus nonwhites and older versus younger girls were more likely to receive contraceptive provision. The presence of a federal risk mitigation system for the teratogen also increased the likelihood of contraceptive provision.

CONCLUSIONS:
Our data demonstrate female adolescents prescribed teratogens receive inadequate contraception provision, which could increase their risk for negative pregnancy outcomes. Although the presence of a federal risk mitigation system appears to improve contraceptive provision, these systems are costly and, in some instances, difficult to implement. Efforts to improve provider practices are needed.
Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas
Authors: Wassermann Johanna , Bernier Marie-Odile , Spano Jean-Philippe , Lepoutre-Lussey Charlotte , Buffet Camille , Simon Jean-Marc , Ménégaux Fabrice , Tissier Frédérique , Leban Monique , Leenhardt Laurence 
Published: December 2015

Abstract

Background.
Outcomes vary among patients with radioiodine refractory (RR) differentiated thyroid cancer (DTC). The prognostic factors for survival are not well-known, resulting in difficulty in selecting patients for new targeted therapies. We assessed overall survival (OS) and cancer-specific survival (CSS) from RR-DTC to identify prognostic factors associated with survival.

Patients and Methods.
The data on all cases of metastatic RR-DTC treated in our center from 1990 to 2011 were retrospectively reviewed. Survival was estimated using the Kaplan-Meier method; associated prognostic factors were assessed using Cox's model.

Results.
Of 153 cases of metastatic DTC, 59% (n = 91) met a criterion for RR: that is, 60% (n = 55) had at least 1 metastasis without 131I uptake; 21% (n = 19) had progressive disease (PD) despite 131I; 19% (n = 17) had persistent disease despite a cumulative activity of 131I of ≥600 mCi. After the diagnosis of RR, median OS was 8.9 years (95% confidence interval [CI]: 5.4-NR); median CSS was 9.6 years (95% CI: 6.01-NR). In multivariate analyses, PD despite 131I as a criterion for RR disease and the time from initial diagnosis of DTC to diagnosis of RR &lt;3 years were the only independent prognostic factors for poor OS and CSS. Thyroglobulin doubling time (Tg-DT) was assessed in 31 of 91 cases. Among the 11 patients with Tg-DT for &lt;1 year or undetectable Tg, 6 deaths occurred, whereas only 3 died of 20 patients with Tg-DT &gt;1 year or negative Tg-DT.

Conclusion.
The identification of prognostic factors for decreased survival in RR-DTC may improve the selection of patients for targeted agents.
Third Sector Commentary: 'A view on neo-liberalism of the sector'
Authors: Mukungu Kate 
Published: December 2015

<p>As a participant in NETSRG, I verbally presented a review of the article by Kim (2013) focusing on voluntary and community sector (VCS) participation in the Self-Sufficiency Programme (SSP), the South Korean equivalent of Welfare to Work. Here I present a written expansion of that verbal review, solely in relation to this article, as opposed to all three articles that made up the session on neo-liberalisation. Before offering my thoughts on Kim’s work, I wish to explain it as my article of choice. </p>
Dynamic Regulation of Tandem 3′ Untranslated Regions in Zebrafish Spleen Cells during Immune Response
Authors: Huang Guangrui , Huang Shengfeng , Wang Ruihua , Yan Xinyu , Li Yuxin , Feng Yuchao , Wang Shaozhou , Yang Xia , Chen Liutao , Li Jun , You Leiming , Chen Shangwu , Luo Guangbin , Xu Anlong 
Published: December 2015

Abstract
Alternative polyadenylation (APA) has been found to be involved in tumorigenesis, development, and cell differentiation, as well as in the activation of several subsets of immune cells in vitro. Whether APA takes place in immune responses in vivo is largely unknown. We profiled the variation in tandem 3′ untranslated regions (UTRs) in pathogen-challenged zebrafish and identified hundreds of APA genes with ∼10% being immune response genes. The detected immune response APA genes were enriched in TLR signaling, apoptosis, and JAK-STAT signaling pathways. A greater number of microRNA target sites and AU-rich elements were found in the extended 3′ UTRs than in the common 3′ UTRs of these APA genes. Further analysis suggested that microRNA and AU-rich element–mediated posttranscriptional regulation plays an important role in modulating the expression of APA genes. These results indicate that APA is extensively involved in immune responses in vivo, and it may be a potential new paradigm for immune regulation.