bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitally gamified co-creation: enhancing community engagement in urban design through a participant-centric framework
Authors: Ng Provides , Zhu Shutong , Li Yuechun , van Ameijde Jeroen 
Published: October 2024

AbstractUrban co-creation is an approach to urban design that actively involves stakeholders and end-users in the design process. As designers increasingly use digital tools to manage design information, stakeholders and residents may find it difficult to participate, resulting in a lack of engagement. The emergence of metaverse technologies offers a crucial opportunity to employ user-friendly and collaborative tools, enabling more effective participation. In the study presented in this article, a custom-designed digital game with virtual reality environment was used to facilitate a series of co-creation workshops. The study focused on changes in participants’ experience by comparing baseline and endline survey results against the design outputs. It employed a holistic framework considering four dimensions: game design, participatory experience, learning outcomes and co-creation results. The findings indicate that the digitally gamified approach helped enhance participation and knowledge sharing, and even though game design ratings varied, the use of video games motivated engagement, particularly in an intergenerational context. The co-creation workshop design documented in this article offers new methods to enhance community engagement in urban design. Especially during digital transformation, it opens renewed discussions on balancing traditional output-driven approaches with more participant-centric methods and design objectives.
Investigating thyroid function and iodine status in adolescents with and without paediatric major depressive disorder
Authors: Osuna Ester , Baumgartner Jeannine , Walther Andreas , Emery Sophie , Albermann Mona , Baumgartner Noemi , Schmeck Klaus , Walitza Susanne , Strumberger Michael , Hersberger Martin , Zimmermann Michael B. , Häberling Isabelle , Berger Gregor , Herter-Aeberli Isabelle 
Published: October 2024

AbstractDepression has been associated with subclinical hypothyroidism and altered hypothalamic-pituitary-thyroid axis functioning. Adequate iodine nutrition is essential for healthy thyroid functioning. We therefore determined associations of iodine and thyroid status with paediatric major depressive disorder (pMDD) among Swiss adolescents and explored whether associations are sex-specific and mediated by stress. We conducted a matched case–control study in 95 adolescents with diagnosed pMDD and 95 healthy controls. We assessed depression severity using the Children’s Depression Rating Scale-Revised and stress using the perceived stress scale (PSS) and measuring hair cortisol levels. We determined iodine status by measuring urinary iodine concentrations (UIC) and thyroid status by thyroid-stimulating hormone (TSH) and free thyroxine (FT4) in serum. Median (IQR) UIC did not differ between cases (121 (87, 174) µg/l) and controls (114 (66, 183) μg/l, P = 0·3). Median TSH and FT4 were lower in cases than controls (TSH: 1·36 (0·91, 2·00) mlU/l v. 1·50 (1·18, 2·06) mlU/l, P = 0·039; FT4: 14·7 (12·9, 16·9) pmol/l v. 15·7 (14·3, 17·2) pmol/l, P = 0·004). The prevalence of hypothyroxinaemia (normal TSH; low FT4) was higher among female cases than controls (21 % v. 4%, P = 0·006). PSS scores were higher while hair cortisol was lower in cases than controls (PSS: 25 (20, 28) v. 11 (7, 15), P < 0·001; cortisol: 2·50 (1·34, 3·57) pg/mg v. 3·23 (1·79, 4·43) pg/mg, P = 0·044). After adjusting for confounders, the associations of TSH and hair cortisol with pMDD were no longer significant. Furthermore, TSH and FT4 were not associated with PSS scores and hair cortisol levels. Summarising, iodine nutrition was adequate for adolescents with and without pMDD. However, FT4 concentrations were lower in those with pMDD, and 1 in 5 female adolescents with pMDD were hypothyroxinaemic.
Plant protein, fibre and physical activity solutions to address poor appetite and prevent undernutrition in older adults: study protocol for the APPETITE randomised controlled trial
Authors: Horner Katy M. , Mullen Brian , Quinn Anna , Scheufele Pia , Gola Susanne , Gonnelli Federica , Bozzato Matteo , Pratt Jedd , Sala Wiktoria , Mullin Sinead , Kirwan Laura , Dardevet Dominique , Guillet Christelle , De Vito Giuseppe , Visser Marjolein , Volkert Dorothee , Corish Clare A. 
Published: October 2024

AbstractReduced appetite with ageing is a key factor that may increase risk of undernutrition. The objective of this study is to determine the impact of innovative plant protein fibre (PPF) products within a personalised optimised diet (PD), a physical activity (PA) programme, and their combination on appetite, and other nutritional, functional and clinical outcomes in community-dwelling older adults in a multi-country randomised controlled intervention trial. One hundred and eighty community-dwelling adults (approximately sixty per trial centre in Germany, Ireland and Italy) aged 65 years and over will be recruited to participate in a 12-week, parallel-group, controlled trial. Participants will be randomised into one of four groups: 1, PD (incorporating two PPF products): 2, PA; 3, PD + PA; and 4, no intervention (control). The primary outcome is appetite measured by visual analogue scales and energy intake from an ad libitum test meal. Secondary outcomes include fasting and postprandial appetite-related gut hormones, Simplified Nutritional Appetite Questionnaire score, body composition, cardiorespiratory fitness, muscle strength, physical function and PA. In addition, self-efficacy, cognitive status, dietary restraint, depressive symptoms and compliance and acceptability of the intervention will be assessed. Metabolomic profiles, RMR, muscle motor unit properties and gut microbiome will also be assessed to explore potential underlying mechanisms. This multi-centre randomised controlled trial will advance knowledge on how PD (incorporating PPF products), PA and their combination influence appetite, nutritional status and related health outcomes in community-dwelling older adults and contribute to the prevention of undernutrition. Trial registration: Clinical Trials.gov Registry NCT05608707 (registered on 2 November 2022). Protocol Version: NCT05608707 Version 4 (registered on 29 September 2023).
Borders, Migration and Asilo Sagrado: How Early Central American Nations Used Open Borders to Reinforce Sovereignty
Authors: Mendiola Daniel 
Published: October 2024

AbstractThis article contributes to broader discussions of early Latin American nation-making by focusing on the interplay among territory, sovereignty and human movement in nineteenth-century Central America. How did early Central American nations create sovereign spaces? And how did human movement in turn impact the meanings of bordered spaces? Drawing from constitutions, legal codes and archival documents related to the implementation of migration laws, the central argument of this article is that Central American governments typically treated free migration not as a threat to sovereignty but as an opportunity to reinforce sovereignty over the fixed spaces through which people moved.
Guwantu: The Yongzheng Emperor's (r. 1723–1735) ‘Illustrated Inventory of Ancient Playthings’ (1729) and Imperial Collecting in Eighteenth Century China
Authors: Grimberg Phillip 
Published: October 2024

AbstractThis article provides a conceptual framework that fills a critical gap at the intersection of Chinese art and cultural history. It focuses on the Yongzheng emperor's ‘Illustrated Inventory of Ancient Playthings’ (Guwantu) and its significance within the context of the collecting and courtly elite culture of the High Qing. Through a comprehensive examination of scroll B/C.8–V&A of the Guwantu itself, as well as the relevant source material, this study elucidates the dynamics that shaped the connections between artist, collector and object in the context of the scroll. Furthermore, this contribution throws light on the multiple entangled relationships that underpinned imperial collecting practices of the period, ultimately offering new insights into the socio-cultural milieu of collectors and connoisseurs in early eighteenth-century China.
A note on extremal constructions for the Erdős–Rademacher problem
Authors: Liu Xizhi , Pikhurko Oleg 
Published: October 2024

AbstractFor given positive integers
$r\ge 3$
,
$n$
and
$e\le \binom{n}{2}$
, the famous Erdős–Rademacher problem asks for the minimum number of
$r$
-cliques in a graph with
$n$
vertices and
$e$
edges. A conjecture of Lovász and Simonovits from the 1970s states that, for every
$r\ge 3$
, if
$n$
is sufficiently large then, for every
$e\le \binom{n}{2}$
, at least one extremal graph can be obtained from a complete partite graph by adding a triangle-free graph into one part.In this note, we explicitly write the minimum number of
$r$
-cliques predicted by the above conjecture. Also, we describe what we believe to be the set of extremal graphs for any
$r\ge 4$
and all large
$n$
, amending the previous conjecture of Pikhurko and Razborov.
The hidden dangers of the coronary anomalies: an ARCAPA case report
Authors: Castillo-Aguilar Luis F. , Rivera-Rodríguez Leonardo , Cervantes-Salazar Jorge L. 
Published: October 2024

AbstractAn anomalous origin of the right coronary artery from the pulmonary artery case report. The diagnosis was made by angiotomography. Reimplantation of the right coronary artery into the ascending aorta and reconstruction of the pulmonary artery were conducted.
Mobile health monitoring of children with CHDs
Authors: LeBlanc Megan E. , Tallent Sarah , Hornik Christoph P. , Camitta Michael G.W. , Schmelzer Anne C. , Kang Lillian , Hill Kevin D. 
Published: October 2024

AbstractBackground:Mobile health has been shown to improve quality, access, and efficiency of health care in select populations. We sought to evaluate the benefits of mobile health monitoring using the KidsHeart app in an infant CHD population.Methods:We reviewed data submitted to KidsHeart from parents of infants discharged following intervention for high-risk CHD lesions including subjects status post stage 1 single ventricle palliation, ductal stent or surgical shunt, pulmonary artery band, or right ventricular outflow tract stent. We report on the benefits of a novel mobile health red flag scoring system, mobile health growth/feed tracking, and longitudinal neurodevelopmental outcomes tracking.Results:A total of 69 CHD subjects (63% male, 41% non-white, median age 28 days [interquartile range 20, 75 days]) were included with median mobile health follow-up of 137 days (56, 190). During the analytic window, subjects submitted 5700 mobile health red flag notifications including 245 violations (mean [standard deviation] 3 ± 3.96 per participant) with 80% (55/69) of subjects submitting at least one violation. Violations precipitated 116 interventions including hospital admission in 34 (29%) with trans-catheter evaluation in 15 (13%) of those. Growth data (n = 2543 daily weights) were submitted by 63/69 (91%) subjects and precipitated 31 feed changes in 23 participants. Sixty-eight percent of subjects with age >2 months submitted at least one complete neurodevelopment questionnaire.Conclusion:In our initial experience, mobile health monitoring using the KidsHeart app enhanced interstage monitoring permitting earlier intervention, allowed for remote tracking of growth feeding, and provided a means for tracking longitudinal neurodevelopmental outcomes.
Global longitudinal strain is a surrogate marker for time constant of isovolumic relaxation in post-Fontan operation patients with single right ventricle and preserved ejection fraction
Authors: Suzuki Kota , Nii Masaki , Tanabe Takehiro , Ishigaki Mizuhiko , Sato Keisuke , Yoshimoto Jun , Kim Sung-Hae , Mitsushita Norie , Tanaka Yasuhiko 
Published: October 2024

AbstractBackground:The time constant of isovolumic relaxation is an established index of ventricular relaxation, a major component of diastolic function, even in a single right ventricle. However, the specific echocardiographic parameters for estimating diastolic dysfunction are insufficient for a single right ventricle. This study aimed to investigate the echocardiographic indices associated with time constant of isovolumic relaxation in post-Fontan operation patients with a single right ventricle.Methods:We included 39 patients with hypoplastic left heart syndrome after Fontan operation with an ejection fraction ≥45% and preserved valve function. First, the correlation between echocardiographic parameters and time constant of isovolumic relaxation was examined, and partial correlation coefficients were calculated using age and heart rate as covariates. Next, univariate regression analysis was performed using time constant of isovolumic relaxation as the objective variable and echocardiographic parameters as independent variables, followed by multivariate regression analysis incorporating parameters with p < 0.10.Results:Among the echocardiographic parameters, global longitudinal strain correlated most strongly with time constant of isovolumic relaxation (r = 0.778, p < 0.001). This was consistent with the partial correlation coefficients (r = 0.707, p < 0.001). Using stepwise multivariate regression analysis, only global longitudinal strain was found to be an independent predictor of time constant of isovolumic relaxation (adjusted R2 = 0.551).Conclusions:Global longitudinal strain could be used as a surrogate marker of time constant of isovolumic relaxation, an invasive indicator of relaxation impairment, in post-Fontan operation patients with a single right ventricle, preserved ejection fraction, and valve function.
Navigating conflicting expectations in addressing healthcare scarcity: a q-methodology study on the Dutch National Health Care Institute
Authors: van de Sande Jolien , de Graaff Bert , Delnoij Diana , de Bont Antoinette 
Published: October 2024

AbstractIn many European countries, semi-autonomous agencies have been created in health policy to safeguard general public interests. In executing their tasks, these agencies need to deal with conflicting expectations. Particularly avoiding the risk of regulatory capture and aligning with parent ministries are frequently studied challenges, even more so when complex issues such as scarcity are at stake. In this paper, we use q-methodology to provide a thorough overview of the debate regarding the role of an important agency in the Dutch healthcare system; the National Health Care Institute (Zorginstituut Nederland). We conducted 41 q-interviews with agency employees, evaluators, regulatees, ministry employees, health policy experts, members of its advisory committees, and peer agencies. We identify three viewpoints on what the agency should focus on. These are on societally relevant issues, strict package management, and efficient organisation of care. In doing so, our study shows how agencies are pulled in different directions by conflicting expectations. We show that this can be problematic because it complicates a clear role of the agency that allows addressing such issues. We thereby contribute to theories on agencies' complex relations with their external environment such as regulatory capture, tripartism, reflexive regulation, legal boundaries, and stewardship theory.
Strong Energy Conversion by a Ribbon‐Like Magnetic Structure in Tailward High‐Speed Flow
Authors: Du C. X. , Fu H. S. , Cao J. B. , Wang Z. , Grigorenko E. , Fu W. D. 
Published: October 2024

AbstractThe tailward high‐speed flows, in which various kinetic processes and magnetic structures can be embedded, are usually produced by the magnetic reconnection in the Earth's magnetotail. Here, using high‐resolution measurements from the Magnetospheric Multiscale (MMS) mission, we report an intense current in the tailward high‐speed flow. The current density can reach ∼180 nA/m2 and is primarily carried by electrons. Taking advantage of the First‐Order Taylor Expansion (FOTE) method, we reveal that such an intense current is associated with a ribbon‐like magnetic structure. A large electric field, reaching ∼90 mV/m, is also observed at the magnetic structure. The Hall term dominates the electric field, however, the contribution from the pressure gradient term and the electron inertial term is nonnegligible and can lead to strong energy conversion (E ⋅ J > 2 nW/m3) through the synergistic action with the intense current. This study improves the understanding of the current behaviors and energy conversion associated with magnetic structures in the Earth's magnetotail.
Electron Pitch Angle Distributions in Magnetotail Tailward Flows
Authors: Wei Y. Y. , Huang S. Y. , Jiang K. , Yuan Z. G. , Xu S. B. , Zhang J. , Xiong Q. Y. , Wang Z. , Lin R. T. , Yu L. 
Published: October 2024

AbstractElectron pitch angle distributions (PADs) are crucial to revealing electron acceleration and heating in geospace. The electron PADs in the Earth's magnetotail have been widely studied by statistical or case analysis. However, the statistical features of electron PADs in tailward flows are still unclear. We survey data from the Magnetospheric Multiscale (MMS) satellite to statistically investigate electron PADs in tailward flows in the Earth's magnetotail for the first time. We find that for most (66.3%) tailward flows, electrons with energy from 0.1 to 30 keV are mainly field‐aligned. The PADs of suprathermal (>2 keV) electrons in a part of tailward flows (26.3%) are mostly isotropic. Additionally, the perpendicular‐dominated PADs of suprathermal electrons only exist in a few (7.4%) tailward flows. According to the different dominant PADs of suprathermal electrons, the tailward flows are classified into three types: field‐aligned‐dominated type, isotropic‐dominated type and perpendicular‐dominated type flows. The dependence of electron PADs on plasma environmental parameters is investigated in these three types of flows. For field‐aligned‐dominated type flows, the field‐aligned anisotropy decreases toward the central plasma sheet (CPS) and with the increase of the energy. In addition, it is found that the field‐aligned anisotropy in the field‐aligned‐dominated tailward flows reduces noticeably when the |Vix| exceeds 800 km/s. In isotropic‐dominated type flows, the field‐aligned anisotropy of electrons with energy ≥10 keV also shows a slight decreasing trend toward the CPS. For perpendicular‐dominated type flows, the perpendicular anisotropy exhibits two non‐monotonic processes, initially increasing and then decreasing with the increase of distance from the CPS; while becomes more evident for higher energy electrons. Our statistical results indicate that in tailward flows, electron anisotropy depends on the distance from the CPS, energy and plasma flow velocity. Tailward flows are associated with the transport of plasma toward the distant tail, and the statistical analysis of electron PADs in these flows can improve our understanding of the related electron dynamics in the magnetotail.
Simulating the Response of Tropical Cyclones to Potential Nuclear War
Authors: Zhao Kai , Zhao Haikun , Coupe Joshua , Klotzbach Philip J. , Wu Liguang 
Published: October 2024

AbstractNuclear war would cause massive amounts of smoke from its associated explosions and fires that would subsequently inject copious amounts of aerosols into the stratosphere. There would also be considerable changes to the global climate system, threatening human health and sustainability. Our work reveals a reduction of global‐scale tropical cyclones (TCs) from a simulation of a nuclear war scenario that could produce ∼150 million tons of smoke. In response to nuclear war, there would be spatially uneven cooling that would result in an anomalous sea surface temperature (SST) gradient pattern. Associated with this would be an anomalous zonal vertical circulation, tending to suppress upward motion and increase vertical wind shear over all TC main development regions, largely explaining the observed TC reduction at regional and global scales. This study improves our understanding of the impact of nuclear war on the TC environment.
An Economical Open‐Source Lagrangian Drifter Design to Measure Deep Currents in Lakes
Authors: McCaffrey Lewis , Koeberle Alexander L. 
Published: October 2024

AbstractThe objective was to construct and test an economical, accurate, and open‐source Lagrangian drifter design suitable for lakes <200 km2. Lagrangian drifters are used to trace water currents in marine and freshwater settings and comprise of a low‐friction surface float containing instrumentation for location and environmental measurement, tethered to a high‐friction drogue at the depth of interest. Oceanic drifters are robust but expensive, and this design tailored to inland lake waterbodies fills a durability and cost gap for lake environments. Water‐following characteristics were tested using theoretical drag coefficient calculations, practical drag measurements, and comparison of wind and drifter vectors while deployed on two deep inland lakes (maximum area 175 km2) in the Finger Lakes region of New York, USA. The ratio of drag between float and drogue met or exceeded the minimum value of 40 recommended in the literature, and the vectors of wind and drifter during deployment were independent of one another, meaning the device accurately traced the movement of water currents at depth without undue influence of wind and waves. Each device cost USD $265 in 2021 and was built from materials readily available at hardware and sporting goods stores, allowing their use by research institutions and communities with smaller budgets. This design reliably measured lake currents at sampling depths that ranged from 2 to 30 m. We anticipate that this design will have application to a wide range of hydrodynamic and ecological research where empirical insights to physical processes like lake currents are sought by scientists and managers.
Leveraging pleiotropy for the improved treatment of psychiatric disorders
Authors: Woodward Damian J. , Thorp Jackson G. , Middeldorp Christel M. , Akóṣílè Wọlé , Derks Eske M. , Gerring Zachary F. 
Published: October 2024

Abstract
Over 90% of drug candidates fail in clinical trials, while it takes 10–15 years and one billion US dollars to develop a single successful drug. Drug development is more challenging for psychiatric disorders, where disease comorbidity and complex symptom profiles obscure the identification of causal mechanisms for therapeutic intervention. One promising approach for determining more suitable drug candidates in clinical trials is integrating human genetic data into the selection process. Genome-wide association studies have identified thousands of replicable risk loci for psychiatric disorders, and sophisticated statistical tools are increasingly effective at using these data to pinpoint likely causal genes. These studies have also uncovered shared or pleiotropic genetic risk factors underlying comorbid psychiatric disorders. In this article, we argue that leveraging pleiotropic effects will provide opportunities to discover novel drug targets and identify more effective treatments for psychiatric disorders by targeting a common mechanism rather than treating each disease separately.