bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drying Kinetics and Quality Attributes of White Radish in Low Pressure Superheated Steam
Authors: Liu Jianbo , Xue Jing , Xu Qing , Shi Yapeng , Wu Long , Li Zhanyong 
Published: April 2017

Abstract
In this paper, white radish discs were dried in superheated steam at absolute pressure 95 mbar at four levels of drying temperature from 75 °C to 90 °C. The drying kinetics and various quality attributes of white radish were investigated, compared with the results by vacuum drying. By kinetic modeling of drying processes with Fick’s second law, low pressure superheated steam drying (LPSSD) had slightly lower value of effective moisture diffusivity but higher activation energy than vacuum drying. In comparison with vacuum drying, the rehydration capability of dried samples by LPSSD was better due to porous microstructure. Only 25 % or more the total amount of Vitamin C was preserved after drying to the ultimate moisture content, but it was found that some amount of Vitamin C was taken with the exhaust steam and preserved in the condensate.
STARD3 mediates endoplasmic reticulum‐to‐endosome cholesterol transport at membrane contact sites
Authors: Wilhelm Léa P , Wendling Corinne , Védie Benoît , Kobayashi Toshihide , Chenard Marie‐Pierre , Tomasetto Catherine , Drin Guillaume , Alpy Fabien 
Published: April 2017

AbstractStAR‐related lipid transfer domain‐3 (STARD3) is a sterol‐binding protein that creates endoplasmic reticulum (ER)–endosome contact sites. How this protein, at the crossroad between sterol uptake and synthesis pathways, impacts the intracellular distribution of this lipid was ill‐defined. Here, by using in situ cholesterol labeling and quantification, we demonstrated that STARD3 induces cholesterol accumulation in endosomes at the expense of the plasma membrane. STARD3‐mediated cholesterol routing depends both on its lipid transfer activity and its ability to create ER–endosome contacts. Corroborating this, in vitro reconstitution assays indicated that STARD3 and its ER‐anchored partner, Vesicle‐associated membrane protein‐associated protein (VAP), assemble into a machine that allows a highly efficient transport of cholesterol within membrane contacts. Thus, STARD3 is a cholesterol transporter scaffolding ER–endosome contacts and modulating cellular cholesterol repartition by delivering cholesterol to endosomes.
Diagnostic tests for Cushing's syndrome differ from published guidelines: data from ERCUSYN
Authors: Valassi Elena , Franz Holger , Brue Thierry , Feelders Richard A , Netea-Maier Romana , Tsagarakis Stylianos , Webb Susan M , Yaneva Maria , Reincke Martin , Droste Michael , Komerdus Irina , Maiter Dominique , Kastelan Darko , Chanson Philippe , Pfeifer Marija , Strasburger Christian J , Tóth Miklós , Chabre Olivier , Tabarin Antoine , Krsek Michal , Fajardo Carmen , Bolanowski Marek , Santos Alicia , Wass John A H , Trainer Peter J , _ _ 
Published: April 2017

Objective
To evaluate which tests are performed to diagnose hypercortisolism in patients included in the European Registry on Cushing’s syndrome (ERCUSYN), and to examine if their use differs from the current guidelines.

Patients and methods
We analyzed data on the diagnostic tests performed in 1341 patients with Cushing’s syndrome (CS) who have been entered into the ERCUSYN database between January 1, 2000 and January 31, 2016 from 57 centers in 26 European countries. Sixty-seven percent had pituitary-dependent CS (PIT-CS), 24% had adrenal-dependent CS (ADR-CS), 6% had CS from an ectopic source (ECT-CS) and 3% were classified as having CS from other causes (OTH-CS).

Results
Of the first-line tests, urinary free cortisol (UFC) test was performed in 78% of patients, overnight 1 mg dexamethasone suppression test (DST) in 60% and late-night salivary cortisol (LSaC) in 25%. Use of LSaC increased in the last five years as compared with previous years (P < 0.01). Use of HDDST was slightly more frequent in the last 5 years as compared with previous years (P < 0.05). Of the additional tests, late-night serum cortisol (LSeC) was measured in 62% and 48-h 2 mg/day low-dose dexamethasone suppression test (LDDST) in 33% of cases. ACTH was performed in 78% of patients. LSeC and overnight 1 mg DST supported the diagnosis of both PIT-CS and ADR-CS more frequently than UFC (P < 0.05).

Conclusions
Use of diagnostic tests for CS varies across Europe and partly differs from the currently available guidelines. It would seem pertinent that a European consensus be established to determine the best diagnostic approach to CS, taking into account specific inter-country differences with regard to the availability of diagnostic tools.
Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis
Authors: Baxter Roger , Bartlett Joan , Fireman Bruce , Lewis Edwin , Klein Nicola P. 
Published: April 2017

BACKGROUND:
Vaccination against pertussis during pregnancy is recommended to protect newborns, yet there is limited information about the effectiveness of maternal tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) vaccine before the first infant dose of diphtheria, tetanus and acellular pertussis (DTaP) vaccine and during the first year of life in infants who have received DTaP.

METHODS:
In a retrospective cohort study of infants born at Kaiser Permanente Northern California from 2010 to 2015, we estimated the effectiveness of maternal pertussis vaccination for protecting newborns against pertussis in the first 2 months of life and in the first year of life accounting for each infant DTaP dose.

RESULTS:
Among 148 981 newborns, the vaccine effectiveness of maternal Tdap was 91.4% (95% confidence interval [CI], 19.5 to 99.1) during the first 2 months of life and 69.0% (95% CI, 43.6 to 82.9) during the entire first year of life. The vaccine effectiveness was 87.9% (95% CI, 41.4 to 97.5) before infants had any DTaP vaccine doses, 81.4% (95% CI, 42.5 to 94.0) between doses 1 and 2, 6.4% (95% CI, −165.1 to 66.9) between doses 2 and 3, and 65.9% (95% CI, 4.5 to 87.8) after infants had 3 DTaP doses.

CONCLUSIONS:
Maternal Tdap vaccination was highly protective against infant pertussis, especially in the first 2 months of life. Even after infant DTaP dosing, there was evidence of additional protection from maternal Tdap vaccination for the first year of life. This study strongly supports the United States’ current recommendation to administer Tdap during each pregnancy.
Valores de colinesterasa plasmática y eritrocitaria con ácido 6-6‘-ditiodinicotínico (DTNA) como indicador
Authors: Restrepo Cortés Beatriz , Londoño Franco Ángela Liliana , Sánchez López Juan Farid 
Published: April 2017

Se realizó un estudio descriptivo transversal empleando ácido 6-6‘-ditiodinicotínico (DTNA) como indicador para calcular los valores de la actividad de colinesterasa plasmática (AchP) y eritrocitaria (AchE) humana y estandarizarlos para ser utilizados como indicadores de riesgo laboral por exposición a organofosforados y carbamatos en la población de la zona cafetera de Colombia. Se eligió esta técnica pues es una alternativa precisa, sencilla y económica: con pocos interferentes permite analizar AchP y AchE, no se tiene que corregir con hemoglobina; el DTNA es estable congelado o refrigerado y permite analizar muchas muestras en poco tiempo. Se evaluaron 819 muestras de agricultores. La AchE fue significativamente mayor en las personas menores de 45 años y en personas no fumigadoras, la AchP fue mayor en los fumigadores; esto es un indicador de que la población fumigadora se encuentra expuesta a organofosforados y carbamatos de forma prolongada. Se sugiere utilizar como valores máximos de referencia de la AchE y AchP 11378 U/L y 10354 U/L, respectivamente como indicadores de intervención ocupacional.
Kongenitale Struma beim neonatalen Fohlen
Authors: Köhler Kernt , Wehrend Axel , Nieth Jennifer 
Published: April 2017

ZusammenfassungBeschrieben werden zwei Fälle einer angeborenen Struma beim Fohlen sowie deren sonographische Darstellung. Ein Fohlen wies neben einer vergrößerten Schilddrüse skelettale Missbildungen in Form einer Brachygnathia superior und einer Beugefehlstellung der Vordergliedmaßen sowie Anzeichen einer Dysmaturität auf. Aufgrund der schlechten Prognose wurde das Tier euthanasiert. Das zweite Fohlen war prämatur und zeigte eine respiratorische Symptomatik. Unter sympto matischer Therapie bildete sich die Struma innerhalb einiger Wochen zurück.
Alimentäre Thyreotoxikose bei zwei Hunden
Authors: Güssow Arne , Cook Andrea , Rick Markus , Neiger Reto , Kempker Karsten 
Published: April 2017

ZusammenfassungZwei Hunde mit erhöhter Thyroxinkonzentration, von denen einer deutliche klinische Symptome einer Hyperthyreose aufwies, wurden zur diagnostischen Abklärung überwiesen. Mittels gezielter anamnestischer Aufarbeitung, klinischer Untersuchung, weiterführender Labordiagnostik und Szintigraphie konnte eine alimentäre Thyreotoxikose diagnostiziert werden. Ursächlich war in einem Fall die Fütterung von mit Schilddrüsengewebe kontaminiertem rohem Futter (BARF), im anderen Fall ein konventionelles Hundefutter. Nach Futterumstellung verschwanden bei dem betroffenen Hund die klinischen Symptome. Eine Kontrolluntersuchung ergab bei beiden Hunden eine Thyroxinkonzentration im Referenzbereich.
Модифікація структури та функціонально-технологічних властивостей казеїну: наукові та прикладні аспекти
Authors: Гринченко Н. , Тютюкова Д. , Пивоваров П. 
Published: April 2017

У статті узагальнено сучасні явлення про роль казеїну в технологічних процесах перероблення молока, розглянуто фізико-хімічні, хімічні та ферментативні способи модифікації казеїну, висвітлено взаємозв’язок між способами модифікації казеїну та його функціонально-технологічними властивостями, розглянуто основні моделі структури казеїнових міцел, що дозволило спрогнозувати можливість його структурних модифікацій з метою регулювання функціонально-технологічних властивостей. Показано роль кальцію у забезпеченні колоїдної стабільності молока, зазначено, що введення секвестрантів (альгінату натрію) до молока знежиреного за обґрунтованих параметрів підвищує його колоїдну стабільність та може бути використано для регулювання його функціонально-технологічних властивостей. Наведено модель технологічної системи виробництва молока знежиреного зі зміненими функціонально-технологічними властивостями за рахунок модифікації структури казеїнових міцел, що проявляється в підвищенні гідрофільності, здатності до дисоціації, рівномірності розподілу поверхневого заряду.
How Academic Failures Break Up Friendship Ties: Social Networks and Retakes
Authors: Valeeva Diliara , Dokuka Sofia , Yudkevich Maria 
Published: April 2017

Student academic failures have been traditionally explained by their abilities, socioeconomic status, institutional and social environment. However, the same factors are ignored by researchers when it comes to students at risk of dropping out. Using data about dynamic social networks, we study changes in the status of students with retakes. It was revealed that over time students with low academic achievements become socially isolated that increases their risk of dropping out. The article offers recommendations on surmounting such isolation and contributes to studies of social engagement of students in institutional and social environment.
From AIDS to Free Trade Agreements: Knowledge Activism in Thailand’s Movement for Access to Medicines
Authors: Krikorian Gaelle Pascale 
Published: April 2017

This article examines the movement for access to medicines in Thailand, a country that is a privileged site of observation of the new world order of pharmaceuticals and has been at the forefront in many international negotiations on intellectual property. The movement relies on the appropriation of knowledge and expertise about intellectual property laws, which developed in the context of the fight against HIV/AIDS. Treatment activism in Thailand is particularly vigorous and studying it allows us to grasp both the national and transnational dimension of this type of collective action: a global movement that is structured around the notion of "access to medicines," and is in close but rather orthodox relation to medical knowledge. The relations that one can draw between AIDS activism and the movement for access-to-medicines allows one to trace the origins of the latter and helps us understand key features at the core of this movement. But the analysis also shows that, from the outset, the access to medicines movement in Thailand developed through a new form of activism. The notion of knowledge activism is developed in this paper to seize the particularities of the activism at play in Thailand as compared with other forms of collective action relying on the use of knowledge. Knowledge activism is defined not only by the activists’ relation to knowledge–– authoritative and institutionalized knowledge, or lay expertise––but also by the inclusion in the movement of “expert activists” such as doctors, lawyers, or academics, together with “grassroots activists.” Knowledge activism also implies a permanent circulation of knowledge and information between the various categories of actors involved inside, outside and on the fringes of the movement, and results in a hybrid form of collective action that develops beyond the movement and is constantly reconfigured, according to opportunities or pressures.
Analysis of internal personnel marketing in selected mechanical engineering company in Slovakia
Authors: Gogolova Martina , Ponisciakova Oga , Sedlakova Iveta 
Published: April 2017

The paper deals with the significance and analysis of internal personnel marketing in a given enterprise in Slovakia. The analyses arose from the internal documentation of the company, from the company results of projects realised within the field of personnel management and from the survey results. The target group comprises of the company staff themselves, therefore the key role of the internal personnel marketing is to ensure stabilisation of qualified and highly motivated employees, their advancement and correct leadership. In the analysis of various occupations in the analysed company, we focus on the application of marketing mix (product, price, place, and promotion) in the process of personnel management. In the conclusion we suggest some measures, based on individual analyses results, to improve internal personnel marketing of an enterprise.

Keywords: internal personnel marketing, management, employees, marketing mix
Optimization of Enterprise Production Activities Aimed at its Energy Efficiency Increase
Authors: Anisimova Tatiana , Lukishina Ludmila 
Published: April 2017

In the period of crisis in the economy of Russia the changes in the priorities in the solution of the goals of functioning of enterprises has become characteristic for many of them. Among the main goals one can determine the holding of their own positions in the outlets or reorientation of activities in response to changing demands of customers. The solution of the goal of energy efficiency increase which is actual for many enterprises in developed and developing countries has come to the second level. Momentary incomes are now more important than the goals of the increase of utilized resources efficiency that are solved in a planned way every year. Due to this, the main aim of our research is the rationalization of the production programme of the enterprise of chemical industry JSC "KazanOrgSyntez" in the way that the maximization of the income, that is so necessary in the current conditions, would be possible under the conditions of the simultaneous growth of its energy efficiency. Methods of economical and mathematical modeling and linear programming were used in the process of the calculations that were carried out. As a result of the optimization of the production activities of an enterprise, aimed at its energy efficiency increase, the decrease of electrical energy consumption comprised 4.7% with regard to real data. The research showed that enterprises even in hard economic conditions are able to combine the solution of current and long-term goals, not depending on external circumstances.

Keywords: optimization of production activities, enterprise, production plan, economic-mathematical model;
Spatial Potential as an Aspect of Territorial Competitiveness
Authors: Dvorsky Jan , Betakova Jana 
Published: April 2017

States, regions, cities and villages are nowadays forced to compete for attention, the interest and respect of clients, as well as the users of the territory in question (visitors, business people, investors, gifted and agile workforce). The value of a territory is created by its potential, which may have material or immaterial character. A territorial plan not only complexly resolves the spatial arrangement and functional use of a territory but also creates the prerequisites for the permanently sustainable development of a municipality. The aim of the research was the assessment of the potential participation barriers in the implementation of selected environmental management instruments and their impact on permanently sustainable development of urban settlement as well as to develop the recommendations to make this action more effective. On the basis of a research it is possible to assess identified participation barriers using a method of mathematical statistics â€“ Analysis of variance (ANOVA). Through a process of risk assessment and subsequently its implementation into strategic documents on territorial management, the increased competitiveness of the territorial unit can be expected.
Keywords: Assessment; analysis of variance; barriers of participation; territorial plan; competitiveness;
Effectiveness of Expectation Channel of Monetary Transmission Mechanism in Inflation Targeting System: An Empirical Study for Turkey
Authors: Guler Asli 
Published: April 2017

Monetary policy can affect economy through out various transmission mechanisms. One of this transmission mechanisms is expectations channel. The monetary policy can get involved in expectation channel of transmission mechanism by affecting the process of expectations formation. Because the results of policies to be implemented vary according to the expectations, the main challenge in monetary policy is to correctly manage expectations. Because of the fact that only the systematic component of monetary policy (estimated component) can affect forward looking expectations, systematic behavior of the central bank has a critical role in determining the economic consequences of monetary policy. In this study, the effectiveness of expectation channel of transmission mechanism was analyized by VAR model. According the results TCMB cannot affect inflation expectations via both the inflation targets and the policy interest. On the other hand, inflation expectations are affected significantly from actualized inflation rates and exchange rates.

Keywords: Central bank, Expectations, Monetary transmission mechanisms, Monetary policy
Mengkaji Revolusi Mental dalam Perspektif Pendidikan Kristen [Assessing the Mental Revolution from a Christian Education Perpective]
Authors: Kadarmanto Mulyo 
Published: April 2017

<p>Mental Revolution is a priority program of the Indonesian government that aims to produce individuals with good character, an independent mindset, and a national identity that makes them ready to compete in the global era. It also aims to help them see education as the main path to implementing this mental revolution, particularly in character development. Through a review of the literature, the writer will examine the Mental Revolution from the perspective of Christian education: its background, its processes, and its objectives. By comparing and analyzing the Mental Revolution, this study will show the uniqueness of Christian education in realizing transformative education that produces learners as restorative persons, servants, and globalizer in all aspects of life.</p><p><em><span class="showMoreLessContentElement" style="display: inline;">BAHASA INDONESIA ABSTRAK: </span>Revolusi mental sebagai program prioritas pemerintah Indonesia memiliki tujuan untuk menghasilkan individu dan bangsa yang berkarakter, mandiri dan beridentitas dalam menjadikan bangsa yang siap berkompetisi di era global; dan melihat pendidikan sebagai jalur utama melaksanakan revolusi mental, terutama dalam mengembangkan karakter. Melalui tinjauan literatur, penulisan akan mengkaji revolusi mental dari perspektif pendidikan Kristen; latar belakang, proses, dan tujuan dari revolusi mental. Dengan membandingkan dan menganalisis revolusi mental, diharapkan kajian ini dapat menampilkan keunikan pendidikan Kristen dalam mewujudkan pendidikan yang transformatif untuk menjadikan nara didik sebagai restorater, penatalayan dan globalizer dalam seluruh aspek kehidupan di era global.</em></p>
Virtual Reality Compared with Bench-Top Simulation in the Acquisition of Arthroscopic Skill
Authors: Banaszek Daniel , You Daniel , Chang Justues , Pickell Michael , Hesse Daniel , Hopman Wilma M. , Borschneck Daniel , Bardana Davide 
Published: April 2017

Background:
Work-hour restrictions as set forth by the Accreditation Council for Graduate Medical Education (ACGME) and other governing bodies have forced training programs to seek out new learning tools to accelerate acquisition of both medical skills and knowledge. As a result, competency-based training has become an important part of residency training. The purpose of this study was to directly compare arthroscopic skill acquisition in both high-fidelity and low-fidelity simulator models and to assess skill transfer from either modality to a cadaveric specimen, simulating intraoperative conditions.

Methods:
Forty surgical novices (pre-clerkship-level medical students) voluntarily participated in this trial. Baseline demographic data, as well as data on arthroscopic knowledge and skill, were collected prior to training. Subjects were randomized to 5-week independent training sessions on a high-fidelity virtual reality arthroscopic simulator or on a bench-top arthroscopic setup, or to an untrained control group. Post-training, subjects were asked to perform a diagnostic arthroscopy on both simulators and in a simulated intraoperative environment on a cadaveric knee. A more difficult surprise task was also incorporated to evaluate skill transfer. Subjects were evaluated using the Global Rating Scale (GRS), the 14-point arthroscopic checklist, and a timer to determine procedural efficiency (time per task). Secondary outcomes focused on objective measures of virtual reality simulator motion analysis.

Results:
Trainees on both simulators demonstrated a significant improvement (p < 0.05) in arthroscopic skills compared with baseline scores and untrained controls, both in and ex vivo. The virtual reality simulation group consistently outperformed the bench-top model group in the diagnostic arthroscopy crossover tests and in the simulated cadaveric setup. Furthermore, the virtual reality group demonstrated superior skill transfer in the surprise skill transfer task.

Conclusions:
Both high-fidelity and low-fidelity simulation trainings were effective in arthroscopic skill acquisition. High-fidelity virtual reality simulation was superior to bench-top simulation in the acquisition of arthroscopic skills, both in the laboratory and in vivo. Further clinical investigation is needed to interpret the importance of these results.