bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphorylated CCAAT/Enhancer Binding Protein β Contributes to Rat HIV-Related Neuropathic Pain:In VitroandIn VivoStudies
Authors: Yi Hyun , Liu Shue , Kashiwagi Yuta , Ikegami Daigo , Huang Wan , Kanda Hirotsugu , Iida Takafumi , Liu Ching-Hang , Takahashi Keiya , Lubarsky David A. , Hao Shuanglin 
Published: December 2017

Chronic pain is increasingly recognized as an important comorbidity of HIV-infected patients, however, the exact molecular mechanisms of HIV-related pain are still elusive. CCAAT/enhancer binding proteins (C/EBPs) are expressed in various tissues, including the CNS. C/EBPβ, one of the C/EBPs, is involved in the progression of HIV/AIDS, but the exact role of C/EBPβ and its upstream factors are not clear in HIV pain state. Here, we used a neuropathic pain model of perineural HIV envelope glycoprotein gp120 application onto the rat sciatic nerve to test the role of phosphorylated C/EBPβ (pC/EBPβ) and its upstream pathway in the spinal cord dorsal horn (SCDH). HIV gp120 induced overexpression of pC/EBPβ in the ipsilateral SCDH compared with contralateral SCDH. Inhibition of C/EBPβ using siRNA against C/EBPβ reduced mechanical allodynia. HIV gp120 also increased TNFα, TNFRI, mitochondrial superoxide (mtO2·−), and pCREB in the ipsilateral SCDH. ChIP-qPCR assay showed that pCREB enrichment on the C/EBPβ gene promoter regions in rats with gp120 was higher than that in sham rats. Intrathecal TNF soluble receptor I (functionally blocking TNFα bioactivity) or knockdown of TNFRI using antisense oligodeoxynucleotide against TNFRI reduced mechanical allodynia, and decreased mtO2·−, pCREB and pC/EBPβ. Intrathecal Mito-tempol (a mitochondria-targeted O2·−scavenger) reduced mechanical allodynia and decreased pCREB and pC/EBPβ. Knockdown of CREB with antisense oligodeoxynucleotide against CREB reduced mechanical allodynia and lowered pC/EBPβ. These results suggested that the pathway of TNFα/TNFRI–mtO2·−–pCREB triggers pC/EBPβ in the HIV gp120-induced neuropathic pain state. Furthermore, we confirmed the pathway using both cultured neurons treated with recombinant TNFαin vitroand repeated intrathecal injection of recombinant TNFα in naive rats. This finding provides new insights in the understanding of the HIV neuropathic pain mechanisms and treatment.SIGNIFICANCE STATEMENTPainful HIV-associated sensory neuropathy is a neurological complication of HIV infection. Phosphorylated C/EBPβ (pC/EBPβ) influences AIDS progression, but it is still not clear about the exact role of pC/EBPβ and the detailed upstream factors of pC/EBPβ in HIV-related pain. In a neuropathic pain model of perineural HIV gp120 application onto the sciatic nerve, we found that pC/EBPβ was triggered by TNFα/TNFRI–mtO2·−–pCREB signaling pathway. The pathway was confirmed by using cultured neurons treated with recombinant TNFαin vitro, and by repeated intrathecal injection of recombinant TNFα in naive rats. The present results revealed the functional significance of TNFα/TNFRI–mtO2·−–pCREB–pC/EBPβ signaling in HIV neuropathic pain, and should help in the development of more specific treatments for neuropathic pain.
Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs
Authors: Lv Yang , Han Xu , Zhang Chunyan , Fang Yuan , Pu Ning , Ji Yuan , Wang Dansong , Xuefeng Xu , Lou Wenhui 
Published: December 2017

Purpose
Chromogranin A (CgA) and neuron-specific enolase (NSE) are important markers for neuroendocrine tumors; however, the clinical value of combining these markers has not been well studied. In this study, we investigated the utility of each marker individually and in combination for patients with nonfunctional pancreatic neuroendocrine tumors (NF-pNETs).

Patients and Methods
In this study, NF-pNET patients and controls were recruited from December 2011 to March 2016; 784 serum samples from peripheral vein were collected. The clinical characteristics and biomarker values of all the individuals were recorded and analyzed. Tumor burdens were calculated by CT/MRI scan. Receiver-operating characteristic curves were constructed to assess the diagnostic predictive values; sensitivity and specificity were calculated to determine the cut-off value. Therapeutic responses reflected on the changes of the biomarkers’ concentration were assessed by the RECIST criterion. Clinical relations between the prognosis and the biomarker values were also analyzed. Statistical significance was defined as P value less than 0.05.

Results
Among the 167 NF-pNETs patients, 82 were males (49.1%) and the mean age was 50.0 (17.4). The mean CgA values of G1, G2 and G3 NF-pNENs were 75, 121 and 134 μg/L (P < 0.05), respectively. In NF-pNETs, CgA correlated with the WHO tumor grade (WHO G1 vs G2, P < 0.05); the linear regression relationships were found between the tumor burdens (both in pancreas and liver) and CgA concentration (P < 0.001); changes in CgA and NSE concentrations also reflect treatment response (P < 0.001).

Conclusion
CgA and NSE are important diagnostic and follow-up markers in patients with NF-pNETs. The combined monitoring of CgA and NSE possesses more accuracy than individual values of CgA and NSE at predicting prognosis and disease progression.
Racionalidades e irracionalidades en la experiencia psicótica y los trastornos de la Intencionalidad
Authors: Botero Juan José , Dávila Jorge 
Published: December 2017

Se ha presentado mucha controversia, desde hace años, acerca de la capacidad de la psiquiatría para mantener estándares médico-científicos comparables a los de otras especialidades de la medicina. La tendencia más reciente, basada en una fuerte crítica a la última edición del dsm, hace un énfasis particular en tratar de caracterizar los trastornos mentales con base en las neurociencias y abandonar toda otra forma de abordarlos. Este artículo revisa dicha tendencia y propone un enfoque multidimen­sional, haciendo énfasis en la investigación, con herramientas de la fenomenología, de la naturaleza experiencial de muchos trastornos psicopatológicos –especialmente las psicosis–, y mostrando su compatibilidad con el enfoque neurocientífico.
Implementation guidelines for green data centres
Authors: Tubaishat Abdallah , Sumaidaa Sara 
Published: December 2017

Increased reliance on technology and online transactions has increased the heat generated in data centres, due to greater access, storage, aggregation and analysis of such data. This paper discusses the downsides of traditional data centres and highlights the importance of applying green IT practices. It explores the benefits and proposes guidelines on shifting to green data centres. The recommendations to go green are to: a) reduce energy by applying green IT practices, b) eliminate redundancies in server systems and cooling modules, c) turn on power management tools on servers and terminals when applicable, d) utilise newer technologies of power consumption and e) minimise internal barriers to establish a good energy management policy. The benefits expected from the proposed approach are minimised pollution levels and lower the cost of activities, among others. The findings of the study will also contribute to face the challenge of global warming and help in better management and control of power consumption.
Keywords: Traditional data centres, green data centres, green computing, emission.
Technical performance analysis of goalkeepers with respect to the sidedness in Turkish Soccer Super League
Authors: Ziyagil M. Akif 
Published: December 2017

Technical performance analyses of 45 goalkeepers with respect to handedness and sidedness in Turkish Soccer Super League were monitored by hand notation method during the season of 2015 and 2016. The results of this study showed that there were significant differences in the distribution between goalkeeperâ€™s saved and scored actions in the following variables. These were as follows; catch the ball with two hands, reaching the ball with right hand at higher level, reaching the ball with left hand at higher level, penalty kick to the right side, penalty kick to the left side and reaching to right side in one on one situation. Percentages were not significantly differentiated in other variables between two groups. In conclusion, scoring a goal rates were increasing at the left side of goalkeepers in all positions. This weakness of goalkeepers can be due to higher proportions of right handedness goalkeepers.
Keywords: Goalkeeper; sidedness; technical performance analysis
Multi-point monitoring of nitrous oxide emissions in three full-scale conventional activated sludge tanks in Europe
Authors: Bellandi Giacomo , Porro Jose , Senesi Elisa , Caretti Cecilia , Caffaz Simone , Weijers Stefan , Nopens Ingmar , Gori Riccardo 
Published: December 2017

Abstract
The large global warming potential of nitrous oxide (N2O) is currently of general concern for the water industry, especially in view of a new regulatory framework concerning the carbon footprint of water resource recovery facilities (WRRFs). N2O can be generated through different biological pathways and from different treatment steps of a WRRF. The use of generic emission factors (EF) for quantifying the emissions of WRRFs is discouraged. This is due to the number of different factors that can affect how much, when and where N2O is emitted from WRRFs. The spatial and temporal variability of three WRRFs in Europe using comparable technologies is presented. An economically feasible and user-friendly method for accounting for the contribution of anoxic zones via direct gas emission measurements was proven. The investigation provided new insights into the contribution from the anoxic zones versus the aerobic zones of biological WRRF tanks and proved the unsuitability of the use of a single EF for the three WRRFs. Dedicated campaigns for N2O emissions assessment are to be advised. However, similarities in the EF magnitude can be found considering treatment strategy and influent water composition.
Revisiting the Relationships Between Measures of Glycemic Control and Hypoglycemia in Continuous Glucose Monitoring Data Sets
Authors: Gimenez Marga , Tannen Amitai Jeremy , Reddy Monika , Moscardo Vanessa , Conget Ignacio , Oliver Nick 
Published: December 2017

OBJECTIVE
The Diabetes Control and Complications Trial (DCCT) identified an inverse relationship between HbA1c and severe hypoglycemia. We investigated the relationship between hypoglycemia and HbA1c in a large type 1 diabetes cohort on multiple daily injection or insulin pump therapy using blinded continuous glucose monitoring (CGM) data. The impact of real-time CGM on these relationships and how these relationships differ with biochemical definitions of hypoglycemia have also been assessed.

RESEARCH DESIGN AND METHODS
CGM data were obtained from the JDRF CGM randomized control trial. Baseline blinded CGM data were used to assess time in hypoglycemia in all individuals. End point data from the CGM intervention group were used to assess the impact of CGM. Percentage of time spent below 3.9, 3.3, 3.0, and 2.8 mmol/L were calculated and quadratic regression plots drawn. Relationships were analyzed visually, and ANOVA was used to assess relationships between glycemia and time below threshold.

RESULTS
J-shaped relationships were observed for all biochemical hypoglycemia thresholds, with the lowest hypoglycemia risk occurring at HbA1c values between 8.1 and 8.6% (65–70 mmol/mol). The use of an average of 5 days/week of CGM flattened the relationships for 3.3, 3.0, and 2.8 mmol/L, and ANOVA confirmed the loss of relationship for the 3.3 mmol/L threshold using CGM.

CONCLUSIONS
The relationship between hypoglycemia and HbA1c in a population with type 1 diabetes is J-shaped. Lower HbA1c values are still associated with increased hypoglycemia risk, although the magnitude of risk depends on biochemical threshold. Real-time CGM may reduce the percentage time spent in hypoglycemia, changing the relationship between HbA1c and hypoglycemia.
Reduction in Hypoglycemia With the Predictive Low-Glucose Management System: A Long-term Randomized Controlled Trial in Adolescents With Type 1 Diabetes
Authors: Abraham Mary B. , Nicholas Jennifer A. , Smith Grant J. , Fairchild Janice M. , King Bruce R. , Ambler Geoffrey R. , Cameron Fergus J. , Davis Elizabeth A. , Jones Timothy W. ,   on behalf of the PLGM Study Group
Published: December 2017

OBJECTIVE
Short-term studies with automated systems that suspend basal insulin when hypoglycemia is predicted have shown a reduction in hypoglycemia; however, efficacy and safety have not been established in long-term trials.

RESEARCH DESIGN AND METHODS
We conducted a 6-month, multicenter, randomized controlled trial in children and adolescents with type 1 diabetes using the Medtronic MiniMed 640G pump with Suspend before low (predictive low-glucose management [PLGM]) compared with sensor-augmented pump therapy (SAPT) alone. The primary outcome was percentage time in hypoglycemia with sensor glucose (SG) &lt;3.5 mmol/L (63 mg/dL).

RESULTS
In an intent-to-treat analysis of 154 subjects, 74 subjects were randomized to SAPT and 80 subjects to PLGM. At baseline, the time with SG &lt;3.5 mmol/L was 3.0% and 2.8% in the SAPT and PLGM groups, respectively. During the study, PLGM was associated with a reduction in hypoglycemia compared with SAPT (% time SG &lt;3.5 mmol/L: SAPT vs. PLGM, 2.6 vs. 1.5, P &lt; 0.0001). A similar effect was also noted in time with SG &lt;3 mmol/L (P &lt; 0.0001). This reduction was seen both during day and night (P &lt; 0.0001). Hypoglycemic events (SG &lt;3.5 mmol/L for &gt;20 min) also declined with PLGM (SAPT vs. PLGM: events/patient-year 227 vs. 139, P &lt; 0.001). There was no difference in glycated hemoglobin (HbA1c) at 6 months (SAPT 7.6 ± 1.0% vs. PLGM 7.8 ± 0.8%, P = 0.35). No change in quality of life measures was reported by participants/parents in either group. There were no PLGM-related serious adverse events.

CONCLUSIONS
In children and adolescents with type 1 diabetes, PLGM reduced hypoglycemia without deterioration in glycemic control.
THE RELATIONSHIP OF READING INTEREST AND LEARNING MOTIVATION WITH NEWS WRITING SKILLS OF GRADE VIII STUDENTS SMP N 24 PADANG
Authors: Ria Ria , Atmazaki Atmazaki , Abdurahman Abdurahman 
Published: December 2017

HUBUNGAN MINAT BACA DAN MOTIVASI BELAJAR DENGAN KETERAMPILAN MENULIS BERITA SISWA KELAS VIII SMP NEGERI 24 PADANGAbstractThis study aims to explain the following. First, the relationship of reading interest, news writing skill of grade VIII students SMP Negeri 24 Padang. Secondly, the relationship between learning motivation with news writing skills of grade VIII students. Third, the relationship between reading interest and learning motivation with news writing skills of grade VIII students. The population was grade VIII students. Samples are 40 students grade VIII students SMP Negeri 24 Padang performed using proportional random sampling technique. Data were collected through questionnaires and performance tests. Questionnaire was used to see interest in reading and students' motivation, while performance tests conducted to determine the outcome of news writing skills of students. Analysis and discussion of the data is done in accordance with the concept of descriptive correlational study. Based on the research conducted can be summarized as the follows. First, there is a significant correlation between reading interest, the news writing skills of grade VIII students SMP Negeri 24 Padang. Secondly, there is a significant relationship between learning motivation and news writing skill of grade VIII students. Third, there is a significant relationship between interest in reading and learning motivation together with news writing skills students.Key Words: reading, learning motivation, news writing skills AbstractPenelitian ini bertujuan untuk menjelaskan hal-hal berikut. Pertama, hubungan minat baca, keterampilan menulis berita siswa kelas VIII SMP Negeri 24 Padang. Kedua, hubungan antara motivasi belajar dengan kemampuan menulis berita siswa kelas VIII. Ketiga, hubungan antara minat membaca dan motivasi belajar dengan keterampilan menulis berita siswa kelas VIII. Populasi siswa kelas VIII. Sampel sebanyak 40 siswa kelas VIII SMP Negeri 24 Padang dilakukan dengan teknik proportional random sampling. Data dikumpulkan melalui kuesioner dan tes kinerja. Kuesioner tersebut digunakan untuk melihat minat membaca dan motivasi siswa, sedangkan tes kinerja dilakukan untuk mengetahui hasil keterampilan menulis berita siswa. Analisis dan pembahasan data dilakukan sesuai dengan konsep deskriptif korelasional. Berdasarkan penelitian yang dilakukan dapat diringkas sebagai berikut. Pertama, ada hubungan yang signifikan antara minat membaca, keterampilan menulis berita siswa kelas VIII SMP Negeri 24 Padang. Kedua, ada hubungan yang signifikan antara motivasi belajar dan keterampilan menulis berita siswa kelas VIII. Ketiga, ada hubungan yang signifikan antara minat baca dan motivasi belajar bersama dengan kemampuan menulis berita siswa.Kata kunci: membaca, motivasi belajar, keterampilan menulis berita
La Exaltación de la Santa Cruz de Juan Niño de Guevara. Análisis histórico-artístico y proceso de restauración
Authors: Arcos von Haartman Estrella , Capilla Luque Francisco 
Published: December 2017

En este artículo se hace un análisis histórico-artístico de La Exaltación de la Santa Cruz de Juan Niño de Guevara, lienzo que forma parte del programa pictórico de la iglesia de San Julián de Málaga, construida y ornamentada por la Hermandad de la Santa Caridad de Nuestro Señor Jesucristo. Asimismo, se da a conocer el recién concluido proceso de restauración a que ha sido sometida dicha obra.
Rafael Mitjana y Ardison. Arquitecto malagueño (1795-1849)
Authors: Rodríguez Marín Francisco José 
Published: December 2017

Rafael Mitjana y Ardison es uno de los arquitectos malagueños menos conocidos, y a su vez afamados por su responsabilidad en la erección de un monumento de enorme presencia ciudadana como es el dedicado al general Torrijos. En este artículo se desgrana su biografía, que nos revela a un personaje inquieto, bien implantado en la sociedad de su época y cuyaactividad como arquitecto fue enormemente diversificada dentro de la práctica académica y clasicista imperante en su época. Sus actividades empresariales privadas, sus aportaciones a la cartografía, a la difusión del conocimiento o al avance de la técnica, nos desvelan a un profesional de sólida formación artística a la vez que técnica que no se sustrajo a implicarse en la pujante actividad económica iniciada en Málaga a partir del primer tercio del siglo XIX.
Los factores de diferenciación socioespacial de la población en el municipio de Marbella a la luz del censo de 2001
Authors: Natera Rivas Juan José 
Published: December 2017

A partir de la información del Censo de Población de 2001 a nivel de sección censal, en el presente estudio nos interesamos por los factores que subyacen en la diferenciación socioespacial de la población en el municipio de Marbella. Además, comparamos los resultados con los obtenidos en otro estudio utilizando información referida a 1991, para lo cual se han seleccionado las mismas variables, la misma referencia espacial y el mismo método de análisis de la información.
BUNDLES DE PREVENÇÃO DE PNEUMONIA ASSOCIADA À VENTILAÇÃO MECÂNICA: A IMPORTÂNCIA DA MULTIDISCIPLINARIDADE
Authors: Chicayban Luciano Matos , Souza Terra Érika Leandra Velasco , Ribela Jacqueline dos Santos , Barbosa Priscila Ferreira 
Published: December 2017

A pneumonia associada a ventilação mecânica (PAV) é definida como uma infecção pulmonar que surge após 48 horas de intubação ou extubação endotraqueal em pacientes submetidos à ventilação mecânica invasiva. Os fatores de riscos para PAV são diversos e descritos na literatura como modificáveis e não modificáveis. Porém, devido à complexidade das ações preventivas da PAV, tem sido preconizado o uso de pacotes de cuidados (bundles), em vez de medidas isoladas de prevenção. Descrever a importância da multidisciplinaridade nos bundles de prevenção de pneumonia associada à ventilação mecânica.Trata-se de revisão não-sistemática com ensaios clínicos randomizados, prospectivos, nas línguas inglesa e portuguesa. Os artigos foram selecionados na base de dados Pubmed, Lilacs e Scielo sendo pesquisado com os seguintes unitermos: ventilação mecânica, pneumonia associada à ventilação mecânica, bundle. Os bundles têm sido recomendados para substituir as medidas isoladas de prevenção, visto que, a utilização de protocolo melhora a segurança e a qualidade do atendimento na UTI, mas requer adesão e treinamento periódico da equipe multidisciplinar para que possam ser considerados indicadores de qualidade.
Binding Modes of Ligands Using Enhanced Sampling (BLUES): Rapid Decorrelation of Ligand Binding Modes Using Nonequilibrium Candidate Monte Carlo
Authors: Gill Samuel , Lim Nathan M. , Grinaway Patrick , Rustenburg Ariën S. , Fass Josh , Ross Gregory , Chodera John D. , Mobley David 
Published: December 2017

Accurately predicting protein-ligand binding is a major goal in computational chemistry, but even the prediction of ligand binding modes in proteins poses major challenges. Here, we focus on solving the binding mode prediction problem for rigid fragments. That is, we focus on computing the dominant placement, conformation, and orientations of a relatively rigid, fragment-like ligand in a receptor, and the populations of the multiple binding modes which may be relevant. This problem is important in its own right, but is even more timely given the recent success of alchemical free energy calculations. Alchemical calculations are increasingly used to predict binding free energies of ligands to receptors. However, the accuracy of these calculations is dependent on proper sampling of the relevant ligand binding modes. Unfortunately, ligand binding modes may often be uncertain, hard to predict, and/or slow to interconvert on simulation timescales, so proper sampling with current techniques can require prohibitively long simulations. We need new methods which dramatically improve sampling of ligand binding modes. Here, we develop and apply a nonequilibrium candidate Monte Carlo (NCMC) method to improve sampling of ligand binding modes.In this technique the ligand is rotated and subsequently allowed to relax in its new position through alchemical perturbation before accepting or rejecting the rotation and relaxation as a nonequilibrium Monte Carlo move. When applied to a T4 lysozyme model binding system, this NCMC method shows over two orders of magnitude improvement in binding mode sampling efficiency compared to a brute force molecular dynamics simulation. This is a first step towards applying this methodology to pharmaceutically relevant binding of fragments and, eventually, drug-like molecules. We are making this approach available via our new Binding Modes of Ligands using Enhanced Sampling (BLUES) package which is freely available on GitHub.