bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing risk‐based care of the childhood cancer survivor in the 21st century
Authors: Dixon Stephanie B. , Bjornard Kari L. , Alberts Nicole M. , Armstrong Gregory T. , Brinkman Tara M. , Chemaitilly Wassim , Ehrhardt Matthew J. , Fernandez‐Pineda Israel , Force Lisa M. , Gibson Todd M. , Green Daniel M. , Howell Carrie R. , Kaste Sue C. , Kirchhoff Anne C. , Klosky James L. , Krull Kevin R. , Lucas John T. , Mulrooney Daniel A. , Ness Kirsten K. , Wilson Carmen L. , Yasui Yutaka , Robison Leslie L. , Hudson Melissa M. 
Published: January 2018

AbstractThe population of adult survivors of childhood cancer continues to grow as survival rates improve. Although it is well established that these survivors experience various complications and comorbidities related to their malignancy and treatment, this risk is modified by many factors that are not directly linked to their cancer history. Research evaluating the influence of patient‐specific demographic and genetic factors, premorbid and comorbid conditions, health behaviors, and aging has identified additional risk factors that influence cancer treatment‐related toxicity and possible targets for intervention in this population. Furthermore, although current long‐term follow‐up guidelines comprehensively address specific therapy‐related risks and provide screening recommendations, the risk profile of the population continues to evolve with ongoing modification of treatment strategies and the emergence of novel therapeutics. To address the multifactorial modifiers of cancer treatment‐related health risk and evolving treatment approaches, a patient‐centered and risk‐adapted approach to care that often requires a multidisciplinary team approach, including medical and behavioral providers, is necessary for this population. CA Cancer J Clin 2018;68:133‐152. © 2018 American Cancer Society.
Les services de transport à l'abbaye de Prum au IXème siècle
Authors: Devroey Jean-Pierre 
Published: January 2018

Les transports à longue distance sont attestés dans le polyptyque de l'abbaye de Prûm sous la forme de deux prestations de services : Yangaria, charroi lourd de produits agricoles, en général des céréales ou du vin, et la scara, transport, à pied, à cheval ou en bateau de diverses marchandises ou objets de poids et de dimension minimes.
Scara et angaria obéissent à un plan d'ensemble, rendu indispensable par l'importance et la dispersion du temporel. Le surproduit global est centralisé à Prùm, après avoir été rassemblé, au niveau régional, dans des domaines-étapes. Il est indéniable qu'il fait l'objet d'une commercialisation. L'abbaye confie à certains tenanciers la vente de sel et de vin. Une partie des angariae et scarae est dirigée vers des centres urbains. Parallèlement, l'abbaye suscite l'apparition de marchés.
L'enquête menée montre la profonde interpénétration des économies domaniale et commerciale, des villes et des campagnes. Le recensement des mentions, après report sur la carte, permet de se rendre compte de l'extrême densité d'un trafic qui se fait sur terre comme sur eau, des forêts de l'Eifel au cours du Rhin, de la Moselle, du Main.
A propos de la tombe de Ronchin. Un auxiliaire gaulois en terre étrangère
Authors: Deru Xavier 
Published: January 2018

Xavier Deru, Het graf van Ronchin. Een gallische hulp- soldaat in vreemde grond.
In het graf van Ronchin, in Menapisch gebied, omvat de graf gift een zwaard en daarom neemt men aan dat het om een hulpsoldaat gaat. Aan de hand van het keramiek- materiaal kan men uitmaken dat hij gestorven is na de burgeroorlog, tijdens de regering van Augustus (10 voor tot 20 na Chr.). Hij is waarschijnlijk afkomstig van de middenvallei van de Loire. Bijna aile keramiek is uit die streek afkomstig, wat zeer verschilt van de lokale pro- ductie. Men kan zo denken aan een hulpsoldaat die in de vreemde gestorven is op grond die hij wegens zijn ver- dienste gekregen had.
Using Species Distribution Models to Guide Field Surveys for an Apparently Rare Aquatic Beetle
Authors: Tronstad Lusha M. , Brown Kelsey M. , Andersen Mark D. 
Published: January 2018

Abstract
Surveying for rare animals can be difficult but using models to predict suitable habitat can guide sampling efforts. We used models to predict suitable habitat for the Narrow-footed Hygrotus Diving Beetle Hygrotus diversipes (diving beetle hereafter), a dytiscid beetle that is known from 10 streams in central Wyoming. The diving beetle was a category-2 Candidate species for listing as Threatened or Endangered in the Endangered Species Act between 1989 and 1996, and was petitioned for listing in 2007, 2008, and 2013. Suitable habitat for the diving beetle was predicted using Maximum Entropy and Random Forest models in Wyoming. Both models predicted that the diving beetle was more likely to occur in intermittent streams with a gentle gradient, shallow water table, variable precipitation pattern, and high soil electrical conductivity, and in the warmest areas of Wyoming. We conducted surveys for the diving beetle at sites where the species had previously been found, and in new areas that were predicted suitable by our models to evaluate whether it is more widely distributed than indicated by previous estimates. We sampled beetles using dip nets and bottle-traps, and assessed water quality at each site. We collected the diving beetle at three sites in central Wyoming between 2010 and 2012 in small, alkaline, intermittent streams with disconnected pools. The aquatic habitat of the diving beetle is dynamic and our results suggest that annual precipitation patterns have a strong influence on the biogeography of this habitat. Our results also suggest that maintaining the hydrologic integrity of prairie streams in Wyoming is vital to the conservation of the diving beetle.
<b>Influence of Lactose Concentration in Bioethanol Production from Cheese Whey
Authors: Murari Cleidiane Samara , Silva Débora Cristina Moraes Niz da , Silva Bruna Lima da , Bianchi Vanildo Luiz Del 
Published: January 2018

The present study aimed the utilization of the cheese whey as substrate for ethanol production by Kluyveromyces marxianus. Was studied the effect of the initial concentration of cheese whey (M1 57,6 g L-1; M2 45,6 g L-1; M3 32,5 g L-1 e M4 18,8 g L-1) on the alcoholic fermentation. After sterilization, the medium were incubated at 30ºC for 48 hours, performing analysis of lactose, proteins, ethanol, cell growth and chemical oxygen demand. According to the results, the medium M1 (the highest concentration) showed a higher production and productivity of ethanol 16.9 g L-1 and 1.26 g L.h-1, respectively, and also obtained the highest production and productivity of cell of 5.8 g L-1 and 0.40 g L.h-1, respectively. However, in terms of ethanol yield, the most satisfactory result was obtained with the M3 medium with 82.30% in 12 hours of fermentation. The organic substances content has been reduced in relation to COD in the medium M4 in 82.28%, representing a promising alternative for valorization of cheese whey as an effective alternative to obtain a renewable source of biofuel.
Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies
Authors: Prohaska Thomas A. , Que Xuchu , Diehl Cody J. , Hendrikx Sabrina , Chang Max W. , Jepsen Kristen , Glass Christopher K. , Benner Christopher , Witztum Joseph L. 
Published: January 2018

Abstract
B-1 cells are a unique subset of B cells that are positively selected for expressing autoreactive BCRs. We isolated RNA from peritoneal (B-1a, B-1b, B-2) and splenic (B-1a, marginal zone, follicular) B cells from C57BL/6 mice and used 5′-RACE to amplify the IgH V region using massively parallel sequencing. By analyzing 379,000 functional transcripts, we demonstrate that B-1a cells use a distinct and restricted repertoire. All B-1 cell subsets, especially peritoneal B-1a cells, had a high proportion of sequences without N additions, suggesting predominantly prenatal development. Their transcripts differed markedly and uniquely contained VH11 and VH12 genes, which were rearranged only with a restricted selection of D and J genes, unlike other V genes. Compared to peritoneal B-1a, the peritoneal B-1b repertoire was larger, had little overlap with B-1a, and most sequences contained N additions. Similarly, the splenic B-1a repertoire differed from peritoneal B-1a sequences, having more unique sequences and more frequent N additions, suggesting influx of B-1a cells into the spleen from nonperitoneal sites. Two CDR3s, previously described as Abs to bromelain-treated RBCs, comprised 43% of peritoneal B-1a sequences. We show that a single-chain variable fragment designed after the most prevalent B-1a sequence bound oxidation-specific epitopes such as the phosphocholine of oxidized phospholipids. In summary, we provide the IgH V region library of six murine B cell subsets, including, to our knowledge for the first time, a comparison between B-1a and B-1b cells, and we highlight qualities of B-1 cell Abs that indicate unique selection processes.
Cutting Edge: Nqo1 Regulates Irritant Contact Hypersensitivity against Croton Oil through Maintenance of Dendritic Epidermal T Cells
Authors: Kitajima Masayuki , Kimura Akihiro , Suzuki Harumi 
Published: January 2018

Abstract
Irritant contact dermatitis (ICD) is associated with local release of inflammatory mediators such as reactive oxygen species and regulated by various antioxidative enzymes and antioxidants. Although Nqo1 is involved in antioxidative reactions and detoxification, its role in ICD remains unknown. Nqo1-deficient mice exhibited augmented ear swelling accompanied by neutrophil infiltration in the croton oil–induced mouse ICD model. In the skin of Nqo1-deficient mice, Vγ5Vδ1+ dendritic epidermal T cells (DETCs), which are known to suppress ICD, were severely reduced. As the transfer of DETCs into Nqo1-deficient mice reversed an increased ICD response, loss of DETCs could account for the increased ICD. DETCs from Nqo1-deficient mice were sensitive to oxidative stress–induced cell death in vitro, and antioxidant NAC treatment in the ears of these mice rescued the number of DETCs and produced a normal ICD response. Taken together, the current results demonstrate that antioxidative enzyme Nqo1 regulates ICD through DETC maintenance.
Pseudoepitheliomatous Hyperplasia: A Diagnostic Dilemma
Authors: Chauhan Anubhav , Gupta Lalit , Chauhan Shveta 
Published: January 2018

AbstractPseudoepitheliomatous hyperplasia (PEH) is a benign reactive inflammatory reaction of the epithelial cells to various conditions. It is a diagnostic dilemma which simulates malignancy, especially squamous cell carcinoma (SCC). Many articles of PEH involving the oral mucosa are available on the internet, but ocular involvement is infrequent. The ocular lesion in our case resembled SCC but turned out to be PEH. We report a rare case of PEH in a 20-year-old male.
CDX2 Expression in Gastric Carcinoma: A Clinicopathological Study
Authors: Halder Aniket , Kundu Mousumi , Das Ram Narayan , Chatterjee Uttara , Datta Chhanda , Choudhuri Manoj Kr , Chatterjee Bitan 
Published: January 2018

Abstract
Background: Gastric cancer accounts for 7.8% of cancers worldwide and adenocarcinoma is the commonest histological type. Both gastric and intestinal phenotypic cell markers are expressed in gastric carcinomas. CDX2 is an intestinal transcription factor, which can be demonstrated in intestinal metaplasia and gastric carcinomas of the intestinal type. Unlike colorectal carcinomas, the role of CDX2 in gastric carcinomas as a prognostic variable is yet to be established. Ki-67 is a transcription factor expressed in the growth and synthetic phases of the cell cycle. Aims and Objectives: The aims of the study were to analyze CDX2 expression and Ki-67 labeling index in different histological types of gastric carcinomas and their relationship with the patients' clinicopathological parameters. Materials and Methods: A total of 50 gastric carcinoma cases were evaluated histologically and phenotypically, along with assessment of CDX2 expression and Ki-67 labeling index. Gastric carcinomas were grouped into intestinal and diffuse types, according to Lauren classification. A semiquantitative microscopic evaluation of CDX2 expression and Ki-67 labeling index was performed and correlated with the patients' clinicopathological parameters. Results: Increased CDX2 expression correlated with higher proportion of intestinal type gastric carcinomas and a lower proportion of lymph node metastasis, lymphovascular and perineural invasion. On the other hand, high Ki-67 labeling index was found in high grade tumors with lymphovascular invasion. Conclusions: The results of our study suggest that CDX2 might be a useful marker in predicting the prognosis of patients with gastric carcinoma. Accordingly, Ki-67 index seems to be useful in identifying a group of patients with aggressive tumors.
Clinicopathological Profile and Treatment Outcomes of Bilateral Breast Cancer: A Study from Tertiary Cancer Center in South India
Authors: Jacob Linu Abraham , Anand Abhishek , Lakshmaiah Kuntegowdanahalli C. , Babu Govind K. , Lokanatha Dasappa , Suresh Babu M.C. Suresh , Lokesh Kadabur N. , Rudresha Antapura Haleshappa , Rajeev L K. , Koppaka Deepak 
Published: January 2018

Abstract
Background: Bilateral breast cancer (BBC) is a rare clinical entity with limited data regarding clinicopathological aspects and treatment guidelines. Materials and Methods: This was an observational study of patients diagnosed with BBC from August 2012 to July 2014. Synchronous breast cancers (SBCs) was defined as two tumors diagnosed within an interval of 6 months and metachronous breast cancer (MBC) as second cancer diagnosed after 6 months. Results: Out of 750 breast cancer patients seen during a 2-year period, 35 had BBC. Ten patients were diagnosed as SBC whereas 25 patients as MBC. Among patients with MBC, the average time for development of contralateral breast cancer was 5 years. In 8 patients, the contralateral breast cancer was detected mammography whereas rest 27 patients were detected by clinical breast examination. At a median follow-up of 24 months, 23 (66%) patients were disease free, 9 (26%) patients had disease relapse, and 3 (8%) patients succumbed to the progressive disease. Conclusions: Every patient with breast cancer should be regularly followed up with clinical breast examination at a more frequent interval. The role of frequent clinical breast examination appears more than mammography especially beyond 5 years for early detection of contralateral breast cancer.
Clinical Profile of Multiple Myeloma in South India
Authors: Fousad Chemban , Gangadharan K V , Abdulla Mansoor C , Naryan Ram , Mohammed Ali 
Published: January 2018

Abstract
Background: The incidence of multiple myeloma (MM) is known to be variable according to ethnicity and is increasing rapidly in Asian countries. Because of huge disparities in economy, lack of adequate health-care infrastructure and the lack of access to novel drugs in our country, treatment of multiple myeloma is still a challenge to medical field in India. Methods: This was a descriptive longitudinal study conducted in the medicine and oncology units of a tertiary care hospital in south India. During the one year period of data collection, 37 cases of multiple myeloma were diagnosed, of which 5 cases were excluded. The diagnosis of MM was made based on the International Myeloma Working Group: Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders. The clinical and laboratory characteristics, and treatment were studied. Results: The male to female ratio was 1.3:1. The commonest symptoms noticed were fatigue 32 (100%) and bone pain 31 (96.9%). 6 (18.8%) patients had hypercalcemia and 7 (21.9%) patients had elevated serum creatinine levels. 29 (91%) of 32 had lytic lesions in the skull and 27 (84%) had lytic lesions in the spine. One patient expired during the course of the treatment. 20 (64%) of 32 patients had partial response to treatment, 7 (23%) had complete response and 4 (13%) of them had stable disease not responding to treatment. Conclusions: To conclude, the patients with multiple myeloma in the present study had a male preponderance. Most common symptoms noticed were fatigue and bone pain and majority had spine tenderness on examination. The presentation of MM is non-specific and patient can come with varied presentations at onset. The quality of life and survival in MM patients can be improved significantly if there is access to newer therapies.
Combined Modality Treatment with “Dexamethasone, Methotrexate, Ifosfamide, L-Asparaginase, and Etoposide ” Chemotherapy and Involved Field Radiotherapy for Early Stage Natural Killer/T Cell Lymphoma with Local Tumor Invasiveness: A Single-institution Study from India
Authors: Gupta Vineet G , Gogia Ajay , Kumar Lalit , Sharma Atul , Bakhshi Sameer , Sharma Mehar C , Mallick Saumyaranjan , Biswas Ahitagni , Mehta Prashant , Thulkar Sanjay , Sahoo Ranjit K , Kumar Rakesh 
Published: January 2018

Abstract
Context: Patients with early stage extranodal natural killer/T-cell lymphoma, nasal type (ES-NKTCL) and local tumor invasiveness (LTI) show poor treatment outcomes with standard approaches. Dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) is an intensive, highly active protocol mainly studied in advanced/recurrent disease. No prior study has utilized this protocol in high-risk ES-NKTCL. Methods: Between 2011 and 2016, all patients with ES-NKTCL with LTI at presentation were uniformly treated at our institute with a combination of SMILE chemotherapy for 5–6 cycles, and involved-field radiotherapy (IFRT). Records of these patients were retrospectively reviewed. Results: Sixteen patients were identified, 69% stage IE and 31% stage IIE. The majority of patients had B-symptoms (75%), paranasal sinus (PNS) invasion (81%), facial skin invasion (56%), palatal perforation (69%), or orbital extension (56%). 12/16 had B-symptoms, and 6/16 had elevated lactate dehydrogenase. All patients received the entire planned 5–6 cycles. IFRT was delivered after a mean 4 cycles. Complete remission was achieved in 13/15 (87%) patients. At a median follow up of 18.5 months, 1-year progression-free survival and overall survival was 84% and 94%, respectively. Grade 3–4 toxicity was seen in 81%, most commonly neutropenia (75%), anemia (44%), and thromobocytopenia (31%). Six patients required dose adjustments (predominantly in the first 1 or 2 cycles). No treatment-related mortality was noted. Conclusion: SMILE with RT is a toxic but tolerable protocol for ES-NKTCL with LTI with high efficacy. Prospective studies are warranted.
Pattern formation mechanisms in sphere-forming diblock copolymer thin films
Authors: Gómez Leopoldo R. , García Nicolás A. , Register Richard A. , Vega Daniel A. 
Published: January 2018

The order-disorder transition of a sphere-forming block copolymer thin film was numerically studied through a Cahn-Hilliard model. Simulations show that the fundamental mechanisms of pattern formation are spinodal decomposition and nucleation and growth. The range of validity of each relaxation process is controlled by the spinodal and order-disorder temperatures. The initial stages of spinodal decomposition are well approximated by a linear analysis of the evolution equation of the system. In the metastable region, the critical size for nucleation diverges upon approaching the order--disorder transition, and reduces to the size of a single domain as the spinodal is approached. Grain boundaries and topological defects inhibit the formation of superheated phases above the order--disorder temperature. The numerical results are in good qualitative agreement with experimental data on sphere-forming diblock copolymer thin films. Received: 22 August 2017, Accepted: 12 December 2017; Edited by: R. Dickman; Reviewed by: A. Peters, Dept. Chemical Engineering, Louisiana Tech Univ., Ruston, USA; DOI: http://dx.doi.org/10.4279/PIP.100001 Cite as: L R Gómez, N A García, R A Register, D A Vega, Papers in Physics 10, 100001 (2018) This paper, by L R Gómez, N A García, R A Register, D A Vega, is licensed under the Creative Commons Attribution License 4.0.
A (in)visibilidade e a criminalização dos indígenas no Brasil: um olhar além do preconceito
Authors: Veronese Osmar , Dornelles Ederson Nadir Pires 
Published: January 2018

Resumo
O presente artigo versa sobre os indígenas brasileiros, os quais, em razão de um processo de vitimização, foram se tornando jurídica e socialmente invisíveis. Além da violência representada pela ocupação do território pelos portugueses e espanhóis, a hipossuficiência desses povos se aprofunda na era capitalista globalizada, na medida em que eles destoam do padrão de vida e consumo imposto pelo mercado mundial. O ensaio examina, também, questões relacionadas à imputabilidade penal, sublinhando o descompasso entre parte da legislação nacional e da internacional sobre a matéria. Ao final, analisa formas de tutela dos indígenas e orientações que informam o julgamento criminal de indígenas, com a necessidade ou dispensa de perícia antropológica, tendo no horizonte o respeito às diferenças. Para essa pesquisa utilizou-se o método de abordagem hipotético-dedutivo, com matizes históricos.
Postwar Europe and the Eurovision Song Contest
Authors: Vuletic Dean 
Published: January 2018

Postwar Europe and the Eurovision Song Contest examines how the Eurovision Song Contest has reflected and become intertwined with the history of postwar Europe from a political perspective.
Established in 1956, the Eurovision Song Contest is the world’s largest popular music event and one of the most popular television programmes in Europe, currently attracting a global audience of around 200 million people. Eurovision is often mocked as cultural kitsch because of its over-the-top performances and frivolous song lyrics. Yet there is no cultural medium that connects Europeans more than popular music, the development of which has always been tied to cultural, economic, political, social and technological change – making Eurovision the ideal tool to explain the history of Europe in the last sixty years. This book uses Eurovision as a vehicle to address topics ranging from the Cold War, liberal democracy and communism to nationalism, European integration, economic prosperity and human rights. It analyses these subjects through their cultural, political and social relationships with Eurovision entries as expressed through lyrics and music, as well as by examining public debates that have accompanied the selection of the entries and the organisation of the contest itself. Postwar Europe and the Eurovision Song Contest also considers how states have used Eurovision to define their identities in a European context, be it to assert their national distinctiveness, highlight political issues or affirm their Europeanism or Euroscepticism in the context of European integration.
Based on original sources, including hitherto unpublished archival documents from international broadcasting organisations, this is a novel historical study of interest to anyone keen to know more about the postwar history of Europe and its cultural history in particular.