bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relation between patient characteristics and their carers’ use of a directive versus collaborative support stance
Authors: Geller Josie , Iyar Megumi , Srikameswaran Suja , Zelichowska Joanna , Zhou Yuan , Dunn Erin C. 
Published: November 2017

AbstractObjectivesCollaborative support provided by carers (family and friends) of individuals with eating disorders has been shown to be integral to patient motivation and clinical outcome. Little is known about factors that contribute to carers’ use of collaborative, as opposed to directive, support stance. This exploratory research investigated associations between patient characteristics and carers’ support beliefs and behaviors.MethodEating disorder patients (n = 72) completed measures of readiness for change, eating disorder, and psychiatric symptom severity, and interpersonal functioning. Their carers (n = 72) completed measures of collaborative and directive support.ResultsPatient demographic variables, readiness for change, and psychiatric symptom severity were not associated with carer beliefs or behaviors. However, some patient interpersonal functioning scores were; higher Domineering/Controlling scores were associated with carers viewing directive support as more helpful, and with their use of more directive support behaviors. Higher Vindictive/Self‐Centered and Intrusive/Needy scores in patients were also associated with carers viewing directive support as more helpful.DiscussionThis exploratory study suggests that carers may be more prone to utilizing a directive, rather than a collaborative, support stance with patients experiencing higher levels of threat, anger, and hostility, and lower levels of safety, closeness, and trust.
3D‐printed Microfluidic Device Based on Cotton Threads for Amperometric Estimation of Antioxidants in Wine Samples
Authors: Carneiro Emmanuelle A. , Agustini Deonir , Figueiredo‐Filho Luiz C. S. , Banks Craig E. , Marcolino‐Junior Luiz Humberto , Bergamini Márcio F. 
Published: November 2017

AbstractThe present work describes the evaluation of microfluidic electroanalytical devices constructed by a 3D printer using ABS (acrylonitrile butadiene styrene) polymer combined with cotton threads as microchannels. Screen‐printed carbon electrodes (SPCEs) were used as electrochemical detector for amperometric determination of gallic and caffeic acid in wine samples. Using optimal experimental conditions (flow rate of 0.71 μL s−1, applied potential of +0.30 V and volume of injection of 2.0 μL) the proposed method presented a linear response for a concentration range of 5.0×10−6 to 1.0×10−3 mol L−1. The detection limits for gallic and caffeic acid were found to 1.5×10−6 mol L−1 and 8.0×10−7 mol L−1, respectively, with a sample throughput of 43 h−1. The achieved results are in agreement with those found using the official Folin‐Ciocaulteu method.
Late Triassic Dabie–Sulu Orocline: New exhumation model of the HP–UHP rocks
Authors: Guo Runhua , Li Sanzhong , Suo Yanhui , Li Xi‐Yao , Liu Xiaoguang , Zhou Zaizheng , Guo Lingli , Wang Qian , Somerville Ian 
Published: November 2017

The Dabie–Sulu orogen is located in the eastern segment of the Central China Orogen between the North China Block (NCB) and the South China Block (SCB). The complex processes of break‐up and assemblage among the continental blocks of East Asia caused them to undergo multiple‐stage continental collisions. It is extremely important for the final kinematics and dynamics of convergence and collision among continental blocks to explore the exhumation mechanism of the HP (high pressure)‐UHP (ultra‐high pressure) metamorphic rocks. Therefore, this paper focuses on the final collisional process and tries to find a reasonable exhumation mechanism of the HP–UHP rocks. On the basis of the structural geology, petrology, seismic tomography, palaeomagnetism, and mathematical calculation, we propose a south‐eastward subduction of the NCB under the SCB in the Indosinian, and the Sulu Orogen actually became an orocline. This was caused by continuous south‐eastward subduction and the subsequent westward‐retreating delamination of the NCB slab. Coevally, it produced a two‐stage exhumation process, a vertical extrusion during the first stage (240–220 Ma) and an eastward extrusion controlled by an oroclinal contraction at the second stage (220–200 Ma).
Type‐1 astrocyte‐like stem cells harboring Cacna1d gene deletion exhibit reduced proliferation and decreased neuronal fate choice
Authors: Völkening Bianca , Schönig Kai , Kronenberg Golo , Bartsch Dusan , Weber Tillmann 
Published: November 2017

AbstractIn the central nervous system, CaV1.2 and CaV1.3 constitute the main L‐type voltage‐gated calcium channels (LTCCs) coupling membrane depolarization to gene transcription. We have previously demonstrated that inducible disruption of Cav1.2 in type‐1 astrocyte‐like stem cells of the adult dentate gyrus (DG) impairs hippocampal neurogenesis in a cell‐autonomous fashion. To address the role of Cav1.3 channels (encoded by the Cacna1d gene), we here generated TgGLAST‐CreERT2/Cacna1dfl/fl/RCE:loxP mice which facilitate inducible deletion of Cacna1d in tandem with induction of EGFP expression in type‐1 cells, allowing tracking of recombined cells and their descendants. Neurosphere cultures derived from fluorescence‐activated cell sorting sorted Cacna1d‐deficient (Cacna1d‐/‐/EGFP) hippocampal neural precursor cells (NPCs) exhibited a significant decrease in proliferative activity. Further, under differentiation conditions, Cacna1d deficiency conferred an increase in astrogenesis at the expense of neurogenesis. In like manner, type‐1 cells lacking Cacna1d showed reduced proliferation in the dentate gyrus (DG) in vivo. Moreover, Cacna1d deficiency resulted in a significant decrease in the number of newly born cells adopting a neuronal fate. Finally, massive excitation induced by repeated electroconvulsive seizures rescued the proliferation defect of Cacna1d‐/‐/EGFP type‐1 cells. Together, the effects of Cacna1d gene deletion closely recapitulate our earlier findings on the role of Cav1.2 channels expressed by type‐1 cells. Similar to Cav1.2 channels, Cav1.3 channels on type‐1 cells boost type‐1 cell proliferation and promote subsequent neuronal fate choice.
Midlife metabolic factors and prostate cancer risk in later life
Authors: Dickerman Barbra A. , Torfadottir Johanna E. , Valdimarsdottir Unnur A. , Wilson Kathryn M. , Steingrimsdottir Laufey , Aspelund Thor , Batista Julie L. , Fall Katja , Giovannucci Edward , Sigurdardottir Lara G. , Tryggvadottir Laufey , Gudnason Vilmundur , Markt Sarah C. , Mucci Lorelei A. 
Published: November 2017

Metabolic syndrome is associated with several cancers, but evidence for aggressive prostate cancer is sparse. We prospectively investigated the influence of metabolic syndrome and its components on risk of total prostate cancer and measures of aggressive disease in a cohort of Icelandic men. Men in the Reykjavik Study (n = 9,097, enrolled 1967–1987) were followed for incident (n = 1,084 total; n = 378 advanced; n = 148 high‐grade) and fatal (n = 340) prostate cancer until 2014. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for (1) measured metabolic factors at cohort entry (body mass index (BMI), blood pressure, triglycerides, fasting blood glucose) and (2) a metabolic syndrome score (range 0–4) combining the risk factors: BMI ≥30 kg/m2; systolic blood pressure (SBP) ≥130 or diastolic blood pressure (DBP) ≥85 mm Hg or taking antihypertensives; triglycerides ≥150 mg/dl; fasting blood glucose ≥100 mg/dl or self‐reported type 2 diabetes. Hypertension and type 2 diabetes were associated with a higher risk of total, advanced, high‐grade, and fatal prostate cancer, independent of BMI. Neither BMI nor triglycerides were associated with prostate cancer risk. Higher metabolic syndrome score (3–4 vs 0) was associated with a higher risk of fatal prostate cancer (HR 1.55; 95% CI: 0.89, 2.69; p trend = 0.08), although this finding was not statistically significant. Our findings suggest a positive association between midlife hypertension and diabetes and risk of total and aggressive prostate cancer. Further, metabolic syndrome as a combination of factors was associated with an increased risk of fatal prostate cancer.
Simulation of Farmland Groundwater Table Depth and Soil Salinity under Drainage Systems in Tidal Areas, Laizhou Bay of China
Authors: Feng Genxiang , Zhang Zhanyu , Lu Peirong , Bakour Ahmad 
Published: November 2017

AbstractDRAINMOD‐S was evaluated using field data from Laizhou Bay, a tidal area in China, for two cropping seasons. Subsurface and conventional drainage were applied in the study area. The DRAINMOD‐S model was calibrated and validated by comparing the observed and predicted values of groundwater table depth drainage discharge and soil salinity. The calibration and validation results were satisfactory with the mean relative error (MSE) less than 10%, Nash–Sutcliffe efficiency (NSE) higher than 0.70 and coefficient of determination (R2) higher than 0.75. The impacts of both subsurface and conventional drainage treatments on groundwater table depth, drainage discharge and soil salinity in 2015–2045 were evaluated with the future climate data provided by the IPCC. Seasonal variations of groundwater table depth and soil salinity were observed under both drainage treatments. The subsurface drainage practice was more suitable for the studied area, with groundwater table depth effectively controlled in the rainy seasons and soil salinity under the crop salt tolerance threshold during most of the predicted periods. This study will highlight the efforts and implementation of drainage management practices to promote sustainable development of agricultural systems in tidal areas under climate change conditions. Copyright © 2017 John Wiley & Sons, Ltd.
Drip Irrigation Scheduling Using Hydrus 2‐D Numerical Model Application for Strawberry Production in South‐West Spain
Authors: García Morillo J. , Rodríguez Díaz J.A. , Camacho E. , Montesinos P. 
Published: November 2017

AbstractEstimation of the optimum irrigation pulse duration and frequency is critical for any crop, and especially important in the typical sandy soil existing in the strawberry production area in south‐west Spain. Irrigation scheduling has been carried out using the numerical model Hydrus‐2D. The model has been calibrated with data from a soil tank experiment carried out in the laboratory. The optimum pulse duration has been estimated in three different crop stages, and has been compared with the irrigation scheduling recorded in the field, estimating the potential water saving in strawberry production in Huelva.The optimum irrigation pulse duration starts with an irrigation time of 10 min that should be increased until a maximum of 1 h, divided into several pulses. Applying rop water needs in several shorter pulses is a strategy highly recommended especially in the typical sandy soil, with very low water retention capacity. It has been shown that current management is disproportionate, maintaining the moisture content out of reach of the roots.Therefore, it is advisable to check the current irrigation management, so that the irrigation matches crop water requirements, maintaining sufficient moisture within the upper 30–40 cm of soil, avoiding water losses by percolation and groundwater pollution. Copyright © 2017 John Wiley & Sons, Ltd.
The Benefit of Using Drainage Water of Fish Farms for Irrigation: Field and Modelling Study Using the SALTMED Model
Authors: Abdelraouf R.E. , Ragab R. 
Published: November 2017

AbstractThis study investigated the suitability and benefits of using drainage water of fish farms (DWFF), instead of canal fresh water (IW), for wheat irrigation. Two water qualities, DWFF and IW, and four levels of N‐fertigation rates [100% N (192 kg N ha−1 season−1), 80% N, 60% N and 40% N] were tested. The results showed a positive impact when increasing N‐fertigation rate on the yield using both DWFF and IW. However, the yield under DWFF was higher than the yield under the IW treatment by between 11 and 51% in 2014 and between 8 and 38% in 2015. This is due to the additional amount of dissolved biological nitrogen and other nutrients inherent in DWFF. The SALTMED model simulated reasonably well the soil moisture and nitrogen content of all soil layers as well as wheat dry matter, yield and water productivity for all treatments, with R2 of 0.99, 0.97 and 0.96, respectively. It was concluded that the use of drainage water of fish farms instead of fresh water for irrigation of wheat could help to achieve higher yields while using less irrigation water and less chemical fertilizers. Additional benefits are less drainage to the drainage network and higher income for farmers. Copyright © 2017 John Wiley & Sons, Ltd.
The synergistic effect of bone forming peptide‐1 and endothelial progenitor cells to promote vascularization of tissue engineered bone
Authors: Wang Huaixi , Cheng Hao , Tang Xiangyu , Chen Jingyuan , Zhang Jun , Wang Wei , Li Wenkai , Lin Guanlin , Wu Hua , Liu Chaoxu 
Published: November 2017

AbstractLarge segmental bone defect repair remains a challenge in orthopedic surgeries. The tissue engineered bone graft will be a promising approach if vascularization of the graft is realized. In this study, beta‐tricalcium phosphate (β‐TCP) scaffold incorporated with bone forming peptide‐1 (BFP‐1) was fabricated. Endothelial progenitor cells (EPCs) were introduced as well. We investigated the effect of BFP‐1 on the proliferation, differentiation, and angiogenic functions of EPCs. Additionally, segmental femur bone defect was created in rabbits. Prevascularized β‐TCP scaffold was constructed and implanted into the bone defect. The vascularization and bone formation were evaluated after 4 and 12 weeks. The results showed that BFP‐1 promoted the angiogenesis of EPCs through activating the activin receptor‐like kinase‐1/Smad pathway. The prevascularized tissue engineered bone graft enhanced capillary vessel in‐growth and new bone formation. Significantly higher values of vascularization and radiographic grading scores were observed in groups involving EPCs and BFP‐1, compared to β‐TCP scaffold alone. In conclusion, the synergy between EPCs and BFP‐1 improved the vascularization and new bone regeneration, which has great potentials in clinical applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1008–1021, 2018.
Biomimetic multidirectional scaffolds for zonal osteochondral tissue engineering via a lyophilization bonding approach
Authors: Clearfield Drew , Nguyen Andrew , Wei Mei 
Published: November 2017

AbstractThe zonal organization of osteochondral tissue underlies its long term function. Despite this, tissue engineering strategies targeted for osteochondral repair commonly rely on the use of isotropic biomaterials for tissue reconstruction. There exists a need for a new class of highly biomimetic, anisotropic scaffolds that may allow for the engineering of new tissue with zonal properties. To address this need, we report the facile production of monolithic multidirectional collagen‐based scaffolds that recapitulate the zonal structure and composition of osteochondral tissue. First, superficial and osseous zone‐mimicking scaffolds were fabricated by unidirectional freeze casting collagen‐hyaluronic acid and collagen‐hydroxyapatite‐containing suspensions, respectively. Following their production, a lyophilization bonding process was used to conjoin these scaffolds with a distinct collagen‐hyaluronic acid suspension mimicking the composition of the transition zone. Resulting matrices contained a thin, highly aligned superficial zone that interfaced with a cellular transition zone and vertically oriented calcified cartilage and osseous zones. Confocal microscopy confirmed a zone‐specific localization of hyaluronic acid, reflecting the depth‐dependent increase of glycosaminoglycans in the native tissue. Poorly crystalline, carbonated hydroxyapatite was localized to the calcified cartilage and osseous zones and bordered the transition zone. Compressive testing of hydrated scaffold zones confirmed an increase of stiffness with scaffold depth, where compressive moduli of chondral and osseous zones fell within or near ranges conducive for chondrogenesis or osteogenesis of mesenchymal stem cells. With the combination of these biomimetic architectural and compositional cues, these multidirectional scaffolds hold great promise for the engineering of zonal osteochondral tissue. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 948–958, 2018.
Bone Material Strength Index as Measured by Impact Microindentation in Postmenopausal Women With Distal Radius and Hip Fractures
Authors: Rozental Tamara D , Walley Kempland C , Demissie Serkalem , Caksa Signe , Martinez-Betancourt Adriana , Parker Amber M , Tsai Joy N , Yu Elaine W , Bouxsein Mary L 
Published: November 2017

ABSTRACT

We tested whether cortical bone tissue properties assessed by in vivo impact microindentation would distinguish postmenopausal women with recent distal radius (DRF) or hip fracture (HF) from nonfracture controls (CONT). We enrolled postmenopausal women with recent DRF (n = 57), HF (n = 41), or CONT (n = 93), and used impact microindentation to assess bone material strength index (BMSi) at the anterior surface of the mid-tibia diaphysis. Areal bone mineral density (aBMD) (g/cm2) of the femoral neck (FN), total hip (TH), and lumbar spine (LS) were measured by dual-energy X-ray absorptiometry (DXA). HF and DRF subjects had significantly lower BMD than CONT at all sites (–5.6% to –8.2%, p &lt; 0.001 for all). BMSi was 4% lower in DRF compared to CONT (74.36 ± 8.77 versus 77.41 ± 8.79, p = 0.04). BMSi was similarly lower in HF versus CONT, but the difference did not reach statistical significance (74.62 ± 8.47 versus 77.41 ± 8.79, p = 0.09). Lower BMSi was associated with increased risk of DRF (unadjusted OR, 1.43; 95% CI, 1.02 to 2.00, per SD decrease, p = 0.04), and remained statistically significant after adjustment for age, age and BMI, and age, BMI, and FN BMD (OR = 1.48 to 1.55). Lower BMSi tended to be associated with HF, but only reached borderline significance (unadjusted OR = 1.39; 95% CI, 0.96 to 2.01, p = 0.08). These results provide strong rationale for future investigations aimed at assessing whether BMSi can predict fracture in prospective studies and improve identification of women at risk for fragility fractures. © 2017 American Society for Bone and Mineral Research.
Removal of jitter noise in 3D shape recovery from image focus by using Kalman filter
Authors: Jang Hoon‐Seok , Muhammad Mannan Saeed , Choi Tae‐Sun 
Published: November 2017

AbstractIn regard to Shape from Focus, one critical factor impacting system application is mechanical vibration of the translational stage causing jitter noise along the optical axis. This noise is not detectable by simply observing the image. However, when focus measures are applied, inaccuracies in the depth occur. In this article, jitter noise and focus curves are modeled by Gaussian distribution and quadratic function, respectively. Then Kalman filter is designed and applied to eliminate this noise in the focus curves, as a post‐processing step after the focus measure application. Experiments are implemented with simulated objects and real objects to show usefulness of proposed algorithm.
Regulation and effects of neurotrophic factors after neural stem cell transplantation in a transgenic mouse model of Alzheimer disease
Authors: Li Bo , Gao Yun , Zhang Wei , Xu Jian‐rong 
Published: November 2017

AbstractAccording to much research, neurodegeneration and cognitive decline in Alzheimer disease (AD) are correlated with alternations of neurotrophic factors such as nerve growth factor, brain‐derived neurotrophic factor, and glial cell–derived neurotrophic factor. The experimental illumination of neural stem cell (NSC) transplantation to eliminate AD symptoms is being explored frequently, and we have acknowledged that neurotrophic factors may play a pivotal role in cognitive improvement. However, the relation between the reversal of cognitive deficits after NSC transplantation and directed alternations of neurotrophic factors is not clearly expounded. Meanwhile, reduced inflammatory response, promoted vessel density, and vascular endothelial growth factor (VEGF) can be reflections of improvement in cerebrovascular function. Three weeks after NSC transplantation, spatial learning and memory function in NSC‐injected (Tg‐NSC) mice were significantly improved compared with vehicle‐injected (Tg‐Veh) mice. Meanwhile, results obtained by immunofluorescence and Western blot analyses demonstrated that the levels of neurotrophic factors, VEGF, and vessel density in the cortex of Tg‐NSC mice were significantly enhanced compared with Tg‐Veh mice, while the levels of proinflammatory cytokines interleukin (IL)‐1β, tumor necrosis factor‐α, and IL‐6 were significantly decreased. Our results suggest that elevated concentrations of neurotrophic factors probably play a critical role in rescuing cognitive dysfunction in APP/PS1 transgenic mice after NSC transplantation, and neurotrophic factors may improve cerebrovascular function by means such as reducing inflammatory response and promoting angiogenesis.
Histamine modulates spinal motoneurons and locomotor circuits
Authors: Coslovich Tamara , Brumley Michele R. , D'Angelo Giuseppe , Della Mora Alberto , Swann Hillary E. , Ortolani Fulvia , Taccola Giuliano 
Published: November 2017

AbstractSpinal motoneurons and locomotor networks are regulated by monoamines, among which, the contribution of histamine has yet to be fully addressed. The present study investigates histaminergic regulation of spinal activity, combining intra‐ and extracellular electrophysiological recordings from neonatal rat spinal cord in vitro preparations. Histamine dose‐dependently and reversibly generated motoneuron depolarization and action potential firing. Histamine (20 µM) halved the area of dorsal root reflexes and always depolarized motoneurons. The majority of cells showed a transitory repolarization, while 37% showed a sustained depolarization maintained with intense firing. Extracellularly, histamine depolarized ventral roots (VRs), regardless of blockage of ionotropic glutamate receptors. Initial, transient glutamate‐mediated bursting was synchronous among VRs, with some bouts of locomotor activity in a subgroup of preparations. After washout, the amplitude of spontaneous tonic discharges increased. No desensitization or tachyphylaxis appeared after long perfusion or serial applications of histamine. On the other hand, histamine induced single motoneuron and VR depolarization, even in the presence of tetrodotoxin (TTX). During chemically induced fictive locomotion (FL), histamine depolarized VRs. Histamine dose‐dependently increased rhythm periodicity and reduced cycle amplitude until near suppression. This study demonstrates that histamine induces direct motoneuron membrane depolarization and modulation of locomotor output, indicating new potential targets for locomotor neurorehabilitation.