bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrast limited fuzzy adaptive histogram equalization for enhancement of brain images
Authors: Magudeeswaran V. , Singh J. Fenshia 
Published: March 2017

ABSTRACTContrast limited fuzzy adaptive histogram equalization (CLFAHE) is proposed to improve the contrast of MRI Brain images. The proposed method consists of three stages. First, the gray level intensities are transformed into membership plane and membership plane is modified with Contrast intensification operator. In the second stage, the contrast limited adaptive histogram equalization is applied to the modified membership plane to prevent excessive enhancement in contrast by preserving the original brightness. Finally, membership plane is mapped back to the gray level intensities. The performance of proposed method is evaluated and compared with the existing methods in terms of qualitative measures such as entropy, PSNR, AMBE, and FSIM. The proposed method provides enhanced results by giving better contrast enhancement and preserving the local information of the original image. © 2017 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 27, 98–103, 2017
In vivo response to decellularized mesothelium scaffolds
Authors: Cronce Michael J. , Faulknor Renea A. , Pomerantseva Irina , Liu Xiang‐Hong , Goldman Scott M. , Ekwueme Emmanuel C. , Mwizerwa Olive , Neville Craig M. , Sundback Cathryn A. 
Published: March 2017

AbstractBiological surgical scaffolds are used in plastic and reconstructive surgery to support structural reinforcement and regeneration of soft tissue defects. Macrophage and fibroblast cell populations heavily regulate scaffold integration into host tissue following implantation. In the present study, the biological host response to a commercially available surgical scaffold (Meso BioMatrix Surgical Mesh (MBM)) was investigated for up to 9 weeks after subcutaneous implantation; this scaffold promoted superior cell migration and infiltration previously in in vitro studies relative to other commercially available scaffolds. Infiltrating macrophages and fibroblasts phenotypes were assessed for evidence of inflammation and remodeling. At week 1, macrophages were the dominant cell population, but fibroblasts were most abundant at subsequent time points. At week 4, the scaffold supported inflammation modulation as indicated by M1 to M2 macrophage polarization; the foreign body giant cell response resolved by week 9. Unexpectedly, a fibroblast subpopulation expressed macrophage phenotypic markers, following a similar trend in transitioning from a proinflammatory to anti‐inflammatory phenotype. Also, α‐smooth muscle actin‐expressing myofibroblasts were abundant at weeks 4 and 9, mirroring collagen expression and remodeling activity. MBM supported physiologic responses observed during normal wound healing, including cellular infiltration, host tissue ingrowth, remodeling of matrix proteins, and immune modulation. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 716–725, 2018.
Atomic force microscopy in the production of a biovital skin graft based on human acellular dermal matrix produced in‐house and in vitro cultured human fibroblasts
Authors: Łabuś Wojciech , Glik Justyna , Klama‐Baryła Agnieszka , Kitala Diana , Kraut Małgorzata , Maj Mariusz , Nowak Mariusz , Misiuga Marcelina , Marcinkowski Andrzej , Trzebicka Barbara , Poloczek Ryszard , Kawecki Marek 
Published: March 2017

AbstractThe most efficient method in III° burn treatment is the use of the autologous split thickness skin grafts that were donated from undamaged body area. The main limitation of this method is lack of suitable donor sites. Tissue engineering is a useful tool to solve this problem. The goal of this study was to find the most efficient way of producing biovital skin substitute based on in house produced acellular dermal matrix ADM and in vitro cultured fibroblasts. Sixty samples of sterilized human allogeneic skin (that came from 10 different donors) were used to examine the influence of decellularizing substances on extracellular matrix and clinical usefulness of the test samples of allogeneic human dermis. Six groups of acellular dermal matrix were studied: ADM‐1 control group, ADM‐2 research group (24 h incubation in 0.05% trypsin/EDTA solution), ADM‐3 research group (24 h incubation in 0.025% trypsin/EDTA solution), ADM‐4 research group (24 h incubation in 0.05% trypsin/EDTA solution and 4 h incubation in 0,1% SDS), ADM‐5 research group (24 h incubation in 0.025% trypsin/EDTA solution and 4 h incubation in 0,1% SDS), and ADM‐6 research group (24 h incubation in 0,1% SDS). Obtained ADMs were examined histochemically and by atomic force microscopy (AFM). ADMs were settled by human fibroblasts. The number of cultured cells and their vitality were measured. The obtained results indicated that the optimal method for production of living skin substitutes is colonization of autologous fibroblasts on the scaffold prepared by the incubation of human allogeneic dermis in 0.05% trypsin/EDTA. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 726–733, 2018.
Enhanced intestinal absorption of curcumin in Caco‐2 cell monolayer using mucoadhesive nanostructured lipid carriers
Authors: Chanburee Sanipon , Tiyaboonchai Waree 
Published: March 2017

AbstractThis study aimed to compare the intestinal permeation of curcumin‐loaded polymer coated nanostructured lipid carriers (NLCs) and uncoated NLCs using the Caco‐2 cell model. The uncoated NLCs were prepared using a warm microemulsion technique, while polymer‐coated NLCs were prepared with the same method but were followed by coating particle surface with polyethylene glycol (PEG) 400 or polyvinyl alcohol (PVA). After lyophilization, all formulations possessed a mean size of <400 nm with a zeta potential of ∼–30 mV and a high entrapment efficacy up to 90%. All NLCs formulation showed significantly improvement in curcumin water solubility, more than 60‐folds as compared to curcumin dispersion. In addition, they could protect curcumin from degradation in basic pH, 90% curcumin remaining after 6 h incubation in culture medium. In vitro permeation studies revealed that PEG–NLCs and PVA–NLCs provided significantly higher apparent permeation coefficient (Papp) value than uncoated NLCs. Moreover, after 6 months storage at 4 °C in the absence of sunlight, the physical, and chemical stabilities of the lyophilized curcumin‐loaded polymer coated NLCs and uncoated NLCs could be maintained, i.e., the mean particle size and the amount of curcumin showed no significant changes (p > 0.05) compared to those freshly prepared formulations. Considered overall, polymer coated NLCs are an important strategy to improve the oral bioavailability of curcumin. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 734–741, 2018.
New approach for vertical bone regeneration using in situ gelling and sustained BMP‐2 releasing poly(phosphazene) hydrogel system on peri‐implant site with critical defect in a canine model
Authors: Seo Bo‐Bae , Chang Hae‐Im , Choi Hyuck , Koh Jeong‐Tae , Yun Kwi‐Dug , Lee Jae‐Yeol , Song Soo‐Chang 
Published: March 2017

AbstractAn injectable hydrogel system with sustained bone morphogenetic protein 2 (BMP‐2) release ability was developed for vertical bone regeneration at peri‐implant sites and enhanced osseointegration of dental implants. In three young male beagle dogs, a pair of defects was created on both sides of the mandibular bone. Next, two implants were transplanted into each defect. In situ gelling polymer solutions with or without BMP‐2 were applied to cover the implants and mandibular defects. The effects of the in situ gelling and sustained BMP‐2 releasing (IGSR) hydrogel system on peri‐implant bone regeneration were evaluated by radiologic examination, micro‐computed tomography, and histomorphometric analysis. Twelve weeks after the treatment, significant bone generation at the peri‐implant site occurred following BMP‐2/IGSR hydrogel treatment. Bone volume and mineral density were increased by 1.7‐ and 1.3‐fold, respectively (p < 0.01 and 0.05 vs. control, respectively) for the BMP‐2/IGSR hydrogel system. And, 0.57–0.31 mm vertical bone generation was observed at the peri‐implant site for the BMP‐2/IGSR hydrogel system, while rare vertical bone generation occurred in the control group. The BMP‐2/IGSR hydrogel system significantly increased bone to implant contact % between induced bone and existing bone (p < 0.05 and 0.01 vs. control).These vertical bone regeneration and higher osseointegration levels demonstrated the effectiveness of the BMP‐2/IGSR hydrogel system. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 751–759, 2018.
Baseline knee adduction moment interacts with body mass index to predict loss of medial tibial cartilage volume over 2.5 years in knee Osteoarthritis
Authors: Brisson Nicholas M. , Wiebenga Emily G. , Stratford Paul W. , Beattie Karen A. , Totterman Saara , Tamez‐Peña José G. , Callaghan Jack P. , Adachi Jonathan D. , Maly Monica R. 
Published: March 2017

ABSTRACTThis study aimed to determine the extent to which changes over 2.5 years in medial knee cartilage thickness and volume were predicted by: (1) Peak values of the knee adduction (KAM) and flexion moments; and (2) KAM impulse and loading frequency, representing cumulative load, after controlling for age, sex and body mass index (BMI). Adults with clinical knee osteoarthritis participated. At baseline and approximately 2.5 years follow‐up, cartilage thickness and volume of the medial tibia and femur were segmented from magnetic resonance imaging scans. Gait kinematics and kinetics, and daily knee loading frequency were also collected at baseline. Multiple linear regressions predicted changes in cartilage morphology from baseline gait mechanics. Data were collected from 52 participants (41 women) [age 61.0 (6.9) y; BMI 28.5 (5.7) kg/m2] over 2.56 (0.51) years. There were significant KAM peak‐by‐BMI (p = 0.023) and KAM impulse‐by‐BMI (p = 0.034) interactions, which revealed that larger joint loads in those with higher BMIs were associated with greater loss of medial tibial cartilage volume. In conclusion, with adjustments for age, sex, and cartilage measurement at baseline, large magnitude KAM peak and KAM impulse each interacted with BMI to predict loss of cartilage volume of the medial tibia over 2.5 years among individuals with knee osteoarthritis. These data suggest that, in clinical knee osteoarthritis, exposure to large KAMs may be detrimental to cartilage in those with larger BMIs. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2476–2483, 2017.
Nocturnal habitat selection of bats using occupancy models
Authors: Pauli Benjamin P. , Zollner Patrick A. , Haulton G. Scott 
Published: March 2017

ABSTRACTThreats to North American bat species necessitate the quantification of bat habitat. To characterize bat habitat, we recorded bat echolocation calls from state forests in Indiana, USA. We identified calls using automated classification software and constructed detection histories for 3 species of conservation concern: Indiana bat (Myotis sodalis), little brown bat (Myotis lucifugus), and northern long‐eared bat (Myotis septentrionalis). We analyzed these data using single‐ and multi‐species occupancy approaches to estimate occurrence and detection probabilities at the genus level (Myotis) and for each species separately. We constructed models using a suite of habitat covariates (e.g., forest cover, edge, streams, hibernacula, public roads) and determined the effect of these features on occupancy for each species (or group). We validated all models using training and independent data. Occupancy of all species was affected by the proportion of forest in surrounding areas. For most models, bat occupancy was greatest in areas with a lower proportion of forest within 1 km. Occupancy was also often greatest in recently harvested or intact, mature second‐growth stands as opposed to stands 10–30 years following harvest. The spatial configuration of water and roads also affected species occupancy. Our methods allowed us to assess the factors that affect occupancy for the genus and individual species, thus allowing for the identification of features useful in classifying important habitat at both taxonomic levels. The results of this study can aid land managers in identifying habitat that may be used by foraging bats and in planning future timber harvests in managed forests. © 2017 The Wildlife Society.
Rational Design of a Conductive Collagen Heart Patch
Authors: Sherrell Peter C. , Cieślar‐Pobuda Artur , Ejneby Malin Silverå , Sammalisto Laura , Gelmi Amy , de Muinck Ebo , Brask Johan , Łos Marek J. , Rafat Mehrdad 
Published: March 2017

Cardiovascular diseases, including myocardial infarction, are the cause of significant morbidity and mortality globally. Tissue engineering is a key emerging treatment method for supporting and repairing the cardiac scar tissue caused by myocardial infarction. Creating cell supportive scaffolds that can be directly implanted on a myocardial infarct is an attractive solution. Hydrogels made of collagen are highly biocompatible materials that can be molded into a range of shapes suitable for cardiac patch applications. The addition of mechanically reinforcing materials, carbon nanotubes, at subtoxic levels allows for the collagen hydrogels to be strengthened, up to a toughness of 30 J m−1 and a two to threefold improvement in Youngs' modulus, thus improving their viability as cardiac patch materials. The addition of carbon nanotubes is shown to be both nontoxic to stem cells, and when using single‐walled carbon nanotubes, supportive of live, beating cardiac cells, providing a pathway for the further development of a cardiac patch.
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To catch an intruder: Part A—uncluttered scenario
Authors: Atkinson Michael P. , Kress Moshe , Szechtman Roberto 
Published: March 2017

AbstractWe analyze an interdiction scenario where an interceptor attempts to catch an intruder as the intruder moves through the area of interest. A motivating example is the detection and interdiction of drug smuggling vessels in the Eastern Pacific and Caribbean. We study two models in this article. The first considers a nonstrategic target that moves through the area without taking evasive action to avoid the interdictor. We determine the optimal location the interceptor should position itself to best respond when a target arrives. The second model analyzes the strategic interaction between the interceptor and intruder using a Blotto approach. The intruder chooses a route to travel on and the interceptor chooses a route to patrol. We model the interaction as a two‐player game with a bilinear payoff function. We compute the optimal strategy for both players and examine several extensions. © 2017 Wiley Periodicals, Inc. Naval Research Logistics, 64: 29–40, 2017
Immobilization of AIEgens into metal‐organic frameworks: Ligand design, emission behavior, and applications
Authors: Gui Bo , Yu Na , Meng Yi , Hu Fang , Wang Cheng 
Published: March 2017

ABSTRACTAggregation‐induced emission (AIE), in which the luminophores are highly emissive in aggregate state, is one of the most unique photophysical phenomena and has shown interesting applications in many areas. The immobilization of AIE luminogens (AIEgens) into metal‐organic frameworks (MOFs), which are inorganic‐organic hybrid porous materials with tunable and predictable structures, has been investigated over the past few years. These well‐defined porous frameworks cannot only provide an ideal platform for studying the mechanism of AIE phenomenon in solid state, but also show potential applications from sensing to white light‐emitting diodes. In this highlight, we will summarize the recent progress of AIEgens‐based MOFs, including ligand design, emission behavior, and applications. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1809–1817
Synthesis of photoactive single‐chain folded polymeric nanoparticles via combination of radical polymerization techniques and Menschutkin click chemistry
Authors: Babaoglu Secil , Karaca Balta Demet , Temel Gokhan 
Published: March 2017

ABSTRACTThis contribution reports that synthesis of polystyrene based photoactive polymeric nanoparticles by radical copolymerization and Menschutkin Chemistry methodology. In the first step, poly(styrene‐co‐chloromethyl styrene) was achieved by thermally initiated radical copolymerizations and subsequently copolymers were reacted to commercially available Type II photoiniator (Michler's ketone) in dilute condition in order to achieve intramolecular crosslinked polymeric nanoparticles. After the characterization studies, polymeric nanoparticles were used for free radical photopolymerization of methacrylic formulations to determine the initiation efficiency. Upon UV irradiation, resulting polymeric nanoparticle lost its globular structure by releasing benzophenone part and transformed into linear copolymer analogue. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1998–2003
Lagrange function method for energy optimization directly in the space of natural orbitals
Authors: Wang Yu , Wang Jian , Lischka Hans 
Published: March 2017

AbstractWe propose a Lagrange method to obtain the electronic energy directly in the space of natural orbitals. The Lagrange function contains constraints to force the off‐diagonal elements of the one‐particle density matrix to zero, so the molecular orbitals converge to the natural orbitals simultaneously while the energy minimizes. The recently discovered “generalized Pauli conditions” for the occupation numbers are invoked to generate an initial approximation. As a demonstration of this approach, we study the system of three electrons in six orbitals which has become a paradigm for investigating multi‐particle entanglement.
Coregistered Hyperspectral and Stereo Image Seafloor Mapping from an Autonomous Underwater Vehicle
Authors: Bongiorno Daniel L. , Bryson Mitch , Bridge Tom C. L. , Dansereau Donald G. , Williams Stefan B. 
Published: March 2017

AbstractWe present a new method for in situ high‐resolution hyperspectral mapping of the seafloor utilizing a spectrometer colocated and coregistered with a high‐resolution color stereo camera system onboard an autonomous underwater vehicle (AUV). Hyperspectral imagery data have been used extensively for mapping and distinguishing marine seafloor habitats and organisms from above‐water platforms (such as satellites and aircraft), but at low spatial resolutions and at shallow water depths (<10 m). The use of hyperspectral sensing from in‐water platforms (such as AUVs) has the potential to provide valuable habitat data in deeper waters and with high spatial resolution. Challenges faced by in‐water hyperspectral imaging include difficulties in correcting for water column effects and the spatial registration of point/line‐scan hyperspectral sensor measurements. The methods developed in this paper overcome these issues through coregistration with a high spatial resolution, stereo color camera, and precise modeling and compensation of the water column properties that attenuate hyperspectral signals. We integrated two spectrometers into our SeaBED class AUV, and one on‐board a support surface vessel to measure and estimate the effects of light passing through the water column. Spatial calibration of the spectrometers/stereo cameras and the synchronized acquisition of both sensors allowed for spatial registration of the resulting hyperspectral reflectance profiles. We demonstrate resulting hyperspectral imagery maps with a spatial resolution of 30 cm over large areas of the seafloor that are not adversely effected by above‐water conditions (such as cloud cover) that would typically prevent the use of remote‐sensing methods. Results are presented from an AUV mapping survey of a coral reef ecosystem over Pakhoi Bank on the Great Barrier Reef, Queensland, Australia, demonstrating the ability to reconstruct hyperspectral reflectance profiles for a diverse range of abiotic and biotic coverage types including sand, corals, seagrass, and algae. Profiles are then used to automatically classify different coverage types with a 10‐fold cross validation accuracy of 91.99% using a linear support vector machine (SVM).
Nano‐sized Recyclable PdO Supported Carbon Nanostructures for Heck Reaction: Influence of Carbon Materials
Authors: Lakshminarayana Bhairi , Mahendar Lodi , Ghosal P. , Satyanarayana Gedu , Subrahmanyam Ch. 
Published: March 2017

AbstractPalladium oxide (PdO) supported carbon nanomaterials were designed and tested for Heck olefination of aryl halides. Various carbonaceous materials, such as single walled carbon nanotubes (SWCNT), multiwalled carbon nanotubes (MWCNT), carbon nanofiber (CNF), graphene oxide (GO) and reduced graphene oxide (RGO) were screened as support for PdO nanoparticles. The structural and phase formation of PdO on carbon materials was confirmed by X‐ray diffraction, whereas, surface area and porous nature of the carbon materials was confirmed by N2 adsorption studies. The morphology of the materials was studied by electron microscopy. Among these catalysts, PdO/GO catalyst showed the best catalytic activity (turnover number 410 and frequency 205 h‐1) for the Heck olefination and the catalyst was reused successfully up to 3 cycles, which confirms the true heterogeneous nature.
Alkyl Substituted Cucurbit[6]uril Assisted Competitive Fluorescence Recognition of Lysine and Methionine in Aqueous Solution
Authors: Bai Qinghong , Zhang Shaowei , Chen Hongrong , Sun Tao , Redshaw Carl , Zhang Jian‐Xin , Ni Xin‐Long , Wei Gang , Tao Zhu 
Published: March 2017

AbstractThe use of competitive ratiometric fluorescence indicator displacement chemosensors derived from two alkyl substituted cucurbit[6]uril‐based host‐guest complexes is reported. In particular, the differing binding abilities of two cucurbit[6]uril derivatives towards the target analytes led to a useful ratiometric detection signal output for the discrimination of lysine and methionine versus the other tested α‐amino acids in aqueous solution.
A production economics analysis for quantifying the efficiency of wind turbines
Authors: Hwangbo Hoon , Johnson Andrew , Ding Yu 
Published: March 2017

AbstractWe quantify the productive efficiency of a wind turbine, using power output and environmental variable data, measured either at the turbine or at a meteorological mast near the turbine. The methods described can potentially help with decision makings in asset procurement, maintenance planning, or wind turbine control optimization. The current recommendation from the International Electrotechnical Commission regarding turbine performance evaluation is to use a power curve or power coefficient. What is commonly used in practice is the average performance power curve or power coefficient. When using the power curve to quantify productive efficiency, one crucial shortcoming is the lack of a common best performance benchmark, while the power coefficient approach uses an absolute efficiency measure that is not achievable. We introduce a new approach for efficiency quantification based upon production economics' concepts which provides estimates of a best performance benchmark. Our specific approach has two main components: (a) a best performance power curve is estimated and used together with the average performance curve to show how well a turbine has performed relative to its full potential; and (b) a covariate matching procedure is developed to control for environmental influences for the comparison of turbine performances over different periods. Through a simulation study, we demonstrate that the proposed efficiency is more sensitive to potential changes in the turbine. When analyzing multi‐year wind turbine data, we observe that the turbine's efficiency is improving during the first 2 years of operation and then remains relatively constant during years 3 and 4. Copyright © 2017 John Wiley & Sons, Ltd.