bluuebunny/crossref_metadata_2025_split huggingface dataset:
CTAPIII/CXCL7: a novel biomarker for early diagnosis of lung cancer
Authors: Du Qiang , Li Encheng , Liu Yonge , Xie Wenli , Huang Chun , Song Jiaqi , Zhang Wei , Zheng Yijie , Wang Huiling , Wang Qi 
Published: January 2018

AbstractIt is desirable to have a biomarker which can facilitate low‐dose CT in diagnosis of early stage lung cancer. CTAPIII/CXCL7 is reported to be a potential biomarker for diagnosis of early lung cancer. In this study, we investigated the serum level of CTAPIII/CXCL7 in patients at different stage of lung cancer and the diagnostic efficacy of CTAPIII/CXCL7 in NSCLC. The plasma level of CTAPIII/CXCL7 was assayed by ELISA. CEA, SCCAg, and Cyfra211 were measured using a commercial chemiluminescent microparticle immunoassay. A total of 419 subjects were recruited, including 265 NSCLC patients and 154 healthy individuals. The subjects were randomly assigned to a training set and a test set. Receiver operating characteristic (ROC) and binary logistic regression analyses were conducted to evaluate the diagnostic efficacy and establish diagnostic mathematical model. Plasma CTAPIII/CXCL7 levels were significantly higher in NSCLC patients than in controls, which was independent of the stage of NSCLC. The diagnostic efficiency of CTAPIII/CXCL7 in NSCLC (training set: area under ROC curve (AUC) 0.806, 95% CI: 0.748–0.863; test set: AUC 0.773, 95% CI: 0.711–0.835) was greater than that of SCCAg, Cyfra21‐1, or CEA. The model combining CTAPIII/CXCL7 with CEA, SCCAg, and Cyfra21‐1 was more effective for NSCLC diagnosis than CTAPIII/CXCL7 alone. In addition, plasma level of CTAPIII/CXCL7 may contribute to the early diagnosis of NSCLC. CTAPIII/CXCL7 can be used as a plasma biomarker for the diagnosis of NSCLCs, particularly early stage lung cancer, with relatively high sensitivity and specificity.
SALL4 ‐ KHDRBS3 network enhances stemness by modulating CD44 splicing in basal‐like breast cancer
Authors: Matsumoto Yoshiaki , Itou Junji , Sato Fumiaki , Toi Masakazu 
Published: January 2018

AbstractUnderstanding the mechanism by which cancer cells enhance stemness facilitates cancer therapies. Here, we revealed that a stem cell transcription factor, SALL4, functions to enhance stemness in basal‐like breast cancer cells. We used shRNA‐mediated knockdown and gene overexpression systems to analyze gene functions. To evaluate stemness, we performed a sphere formation assay. In SALL4 knockdown cells, the sphere formation ability was reduced, indicating that SALL4 enhances stemness. CD44 is a membrane protein and is known as a stemness factor in cancer. CD44 splicing variants are involved in cancer stemness. We discovered that SALL4 modulates CD44 alternative splicing through the upregulation of KHDRBS3, a splicing factor for CD44. We cloned the KHDRBS3‐regulated CD44 splicing isoform (CD44v), which lacks exons 8 and 9. CD44v overexpression prevented a reduction in the sphere formation ability by KHDRBS3 knockdown, indicating that CD44v is positively involved in cancer stemness. In addition, CD44v enhanced anoikis resistance under the control of the SALL4 ‐ KHDRBS3 network. Basal‐like breast cancer is an aggressive subtype among breast cancers, and there is no effective therapy so far. Our findings provide molecular targets for basal‐like breast cancer therapy. In the future, this study may contribute to the establishment of drugs targeting cancer stemness.
Intersectional experiences of discrimination in a low‐resource urban community: An exploratory latent class analysis
Authors: Earnshaw Valerie A. , Rosenthal Lisa , Gilstad‐Hayden Kathryn , Carroll‐Scott Amy , Kershaw Trace S. , Santilli Alycia , Ickovics Jeannette R. 
Published: January 2018

AbstractThere have been increasing calls for the application of an intersectionality framework to understand and address discrimination and health inequities among diverse communities. Yet there have been theoretical debates regarding to whom intersectionality applies and how intersectional experiences of discrimination are associated with health outcomes. The current study aimed to contribute to these theoretical debates and inform practical applications to reduce health inequities. Data were drawn from a community health survey in New Haven, CT (N = 1,293 adults) and analysed using latent class analysis. Results yielded 4 classes. Members of the 4 classes were similar sociodemographically. Three classes of participants reported experiencing discrimination, and members of these classes had greater stress, higher rates of smoking and sleep disruption, and worse overall health than members of the class reporting no discrimination. Members of 2 classes made multiple, or intersectional, attributions for discrimination, and members of these classes reported the most frequent discrimination. Findings suggest that community members who are sociodemographically similar may have diverse discrimination experiences. Multilevel interventions that address multiple forms of discrimination (e.g., racism and sexism) may hold promise for reducing discrimination and, ultimately, health inequities within low‐resource urban community settings.
Bioresorbable vascular scaffold versus everolimus‐eluting stents or drug eluting balloon for the treatment of coronary in‐stent restenosis: 1‐Year follow‐up of a propensity score matching comparison (the BIORESOLVE‐ISR Study)
Authors: Moscarella Elisabetta , Tanaka Akihito , Ielasi Alfonso , Cortese Bernardo , Coscarelli Sebastian , De Angelis Maria Carmen , Piraino Davide , Latib Azeem , Grigis Giulietta , Bianchi Renatomaria , Buccheri Dario , Calabrò Paolo , Tespili Maurizio , Silva Orrego Pedro , Colombo Antonio , Varricchio Attilio 
Published: January 2018

AbstractObjectivesto compare the 1‐year outcome between bioresorbable vascular scaffold (BVS), everolimus‐eluting stent (EES), and drug‐eluting balloon (DEB) for in‐stent restenosis (ISR) treatment.BackgroundBVS has been proposed as alternative for ISR treatment. To date a direct comparison between BVS and DES or DEB for ISR treatment is lacking.MethodsWe retrospectively analyzed all ISR lesions treated with BVS, DEB, and EES from January 2012 to December 2014. A total of 548 lesions (498 patients) were included. By applying two propensity‐score matching, 93 lesions treated with BVS were compared with 93 lesions treated with DEB, and 100 lesions treated with BVS were compared to 100 lesions treated with EES.ResultsAt 1‐year follow‐up the incidence of device‐oriented cardiovascular events (DOCE) and its components did not significantly differ between BVS and DEB (DOCE: 10.9 vs. 11.8%, HR, 0.91; 95% CI, 0.33–2.52; P = 0.86; Cardiac death: 2.2 vs. 1.2%, HR, 1.74, 95% CI 0.16–18.80, P = 0.65; ID‐TLR: 8.9 vs. 10.7%, HR, 0.81, 95% CI 0.27–2.48, P = 0.71; TV‐MI: 3.3 vs. 1.2%, HR, 2.39, 95% CI 0.27–21.32, P = 0.43) and BVS vs. EES (DOCE: 10.1 vs. 5.2% HR, 1.81, 95% CI, 0.63–5.25; P = 0.27; Cardiac death: 3.0 vs. 1.1%; HR, 2.83, 95% CI 0.29–27.4, P = 0.37; ID‐TLR: 7.2 vs. 4.2%, HR, 1.57, 95% CI 0.47–5.23, P = 0.46; TV‐MI: 3.1 vs. 0%).ConclusionAt 1‐year follow‐up the use of BVS as ISR treatment is associated with a higher, even if not significant, DOCE rate compared with EES while a similar rate compared to DEB.
Diffusion‐weighted imaging characteristics of methotrexate‐induced acute encephalopathy
Authors: Yoshimi Mayumi , Abe Shoko 
Published: January 2018

Key Clinical MessageMethotrexate (MTX)‐induced encephalopathy is a grave complication in patients with malignancies. The early diagnosis of acute encephalopathy was difficult by conventional computed tomography (CT), and T1‐ or T2‐weighted magnet resonance (MR) imaging. We report that the diffusion‐weighted (DW) imaging is useful for early detection of acute leukoencephalopathy.
Multicentric castleman's disease resembling metastatic lung carcinoma. A case report
Authors: Testori Alberto , Voulaz Emanuele , Alloisio Marco , Errico Valentina , Cariboni Umberto , De Simone Matilde , Cioffi Ugo 
Published: January 2018

Key Clinical MessageA 67‐year‐old patient presented for persistent cough. Computed tomography showed right lower lung opacity associated with mediastinal adenopathy. On suspicion of metastatic pulmonary neoplasm, the patient was submitted to right lower lobectomy with lymphadenectomy. Postoperative histopathology led to the diagnosis of multicentric Castleman's disease.
Influence of Metal Deposition and Activation Method on the Structure and Performance of Carbon Nanotube Supported Palladium Catalysts
Authors: Lamme Wouter S. , Zečević Jovana , de Jong Krijn P. 
Published: January 2018

AbstractThe effects of the metal deposition and activation methods on metal particle size and distribution were investigated for carbon nanotube supported Pd catalysts. The Pd precursor was loaded by incipient wetness impregnation, ion adsorption, and deposition precipitation and was activated by thermal treatment under a nitrogen atmosphere or in the liquid phase by reduction by formaldehyde or sodium borohydride. Regardless of the metal precursor loading method, activation under a N2 atmosphere at 500 °C led to homogeneously distributed 4 nm Pd particles. Liquid‐phase reduction by sodium borohydride provided a bimodal distribution with particle sizes of approximately 1 and >10 nm. A somewhat weaker reducing agent, formaldehyde, yielded particles approximately 1 nm in size. The activities of the catalysts for the hydrogenation of cinnamaldehyde correlated with the particle sizes.
MoS2‐Nanosheet‐Decorated Carbon Nanofiber Composites Enable High‐Performance Cathode Materials for Mg Batteries
Authors: Tan Yi‐Hong , Zhou Fei , Huang Zhi‐Hong , Yao Wei‐Tang , Zhang Tian‐Wen , Yao Hong‐Bin , Lu Lei‐Lei , Yu Shu‐Hong 
Published: January 2018

AbstractIn rechargeable Mg batteries, kinetically reasonable and electrolyte‐compatible cathode materials are required to achieve high electrochemical performance. Here, we report a high‐performance rechargeable Mg battery cathode material that is constructed from layered structural MoS2 nanosheets decorated on conductive nitrogen‐doped carbon nanofibers (N‐CNFs@MoS2). We demonstrate that N‐CNFs@MoS2 exhibits good electrochemical compatibility in two types of dual‐salt electrolytes including an all‐phenyl complex with lithium chloride (LiCl‐APC) and bis(trifluoromethane)sulfonimide lithium salt with magnesium chloride (MgCl2‐LiTFSI). The fabricated N‐CNFs@MoS2‐Mg batteries based on both dual‐salt electrolyte systems exhibit good cyclic stability and high rate performance.
Recent Advances in the Synthesis of Peptoid Macrocycles
Authors: Webster Alexandra M. , Cobb Steven L. 
Published: January 2018

AbstractOver the past two decades, developing medical applications for peptides has, and continues to be a highly active area of research. At present there are over 60 peptide‐based drugs on the market and more than 140 in various stages of clinical trials. The interest in peptide‐based therapeutics arises from their biocompatibility and their ability to form defined secondary and tertiary structures, resulting in a high selectivity for complex targets. However, there are significant challenges associated with the development of peptide‐based therapeutics, namely peptides are readily metabolised in vivo. Peptoids are an emerging class of peptidomimetic and they offer an alternative to peptides. Peptoids are comprised of N‐substituted glycines where side‐chains are located on the nitrogen atom of the amide backbone rather than the α‐carbon as is the case in peptides. This change in structure confers a high degree of resistance to proteolytic degradation but the absence of any backbone hydrogen bonding means that peptoids exhibit a high degree of conformational flexibility. Cyclisation has been explored as one possible route to rigidify peptoid structures, making them more selective, and, therefore more desirable as potential therapeutics. This review outlines the various strategies that have been developed over the last decade to access new types of macrocyclic peptoids.
Dynamic Polymorph Formation during Evaporative Crystallization from Solution: The Key Role of Liquid‐Like Clusters as “Crucible” at Ambient Temperature
Authors: Oka Narumi , Ito Fuyuki , Haketa Yohei , Maeda Hiromitsu , Miyano Tetsuya , Tohnai Norimitsu , Ito Syoji , Miyasaka Hiroshi , Ozeki Sumio 
Published: January 2018

AbstractUnderstanding the polymorph phenomenon for organic crystals is essential for the development of organic solid materials. Here, the fluorescence study of the evaporative crystallization of 1,3‐dipyrrol‐2‐yl‐1,3‐propanedione boron difluoride complex (1), which has three polymorphs showing different emission profiles, is reported. The droplet of 1 in 1,2‐dichloroethane showed blue emission just after dropping. Solids with bluish‐green emission were observed. As time elapsed, a solid with red or orange emission was observed around the droplet. Time evolution of the fluorescence spectra, observed for the first time, implied that the molten state of 1 was observed by emission of an intermediate, even at ambient temperature. These findings suggested that the liquid‐like cluster incidentally forms an ordered array as the crystallites nucleate. The liquid‐like cluster can be considered as the “crucible” in the nucleation of polymorphs.
9‐Membered Carbocycles: Strategies and Tactics for their Synthesis
Authors: Huber Tatjana , Wildermuth Raphael E. , Magauer Thomas 
Published: January 2018

AbstractMany natural products comprising a nine‐membered carbocyclic core structure exhibit interesting biological effects. However, only a minority have succumbed to their synthesis in the past. The synthesis of functionalized nine‐membered carbocycles still remains a challenging goal for synthetic chemists, mainly due to their high ring strain. Different strategies to overcome the unfavorable enthalpic and entropic factors associated with their formation are highlighted in this Concept article. The presented methods are classified into two different categories: (1) the ring‐expansion of smaller rings or the ring‐contraction of larger rings and (2) the direct cyclization of acyclic precursors.
One‐Carbon Oxidative Annulations of 1,3‐Enynes by Catalytic C−H Functionalization and 1,4‐Rhodium(III) Migration
Authors: Dooley Johnathon D. , Lam Hon Wai 
Published: January 2018

AbstractRhodium(III)‐catalyzed C−H functionalization‐oxidative annulations of aromatic substrates with 1,3‐enynes that contain allylic hydrogen atoms cis to the alkyne are described. The key step in these reactions is an alkenyl‐to‐allyl 1,4‐rhodium(III) migration to give electrophilic π‐allylrhodium(III) species. Nucleophilic trapping of these species gives heterocycles such as benzopyrans, isobenzofuranones, and isoindolinones.
Disulfide‐Linked Dendritic Oligomeric Phthalocyanines as Glutathione‐Responsive Photosensitizers for Photodynamic Therapy
Authors: Chow Sun Y. S. , Wong Roy C. H. , Zhao Shirui , Lo Pui‐Chi , Ng Dennis K. P. 
Published: January 2018

AbstractA series of disulfide‐linked dendritic phthalocyanines were synthesized by using the CuI‐catalyzed alkyne–azide cycloaddition reaction as the key step. Whereas these compounds were essentially nonaggregated in N,N‐dimethylformamide, they were stacked in citrate solution (pH 7.4, with 1 % Cremophor EL), as shown by the broad appearance of their Q‐band absorption. Having two‐to‐six zinc(II) phthalocyanine units in a molecule, these compounds were significantly self‐quenched, particularly in citrate solution. Both the fluorescence intensity and singlet‐oxygen generation efficiency were significantly lower than those of the monomeric counterparts, and the self‐quenching efficiency increased as the number of phthalocyanine units increased. Upon interaction with 5 mm glutathione (GSH) in citrate solution, the fluorescence intensity of these compounds increased as a result of cleavage of the disulfide linkages and separation of the phthalocyanine units, which thereby reduced the self‐quenching effect. The “on/off” ratios were found to be 7, 18, 23, and 21 for the dimeric (PC2), trimeric (PC3), tetrameric (PC4), and hexameric (PC6) systems, respectively. GSH also enhanced the fluorescence emission inside human colon adenocarcinoma HT29 cells and promoted the formation of singlet oxygen of these compounds. Upon irradiation, their half maximal inhibitory concentration (IC50) values were found to be in the range of 0.18 to 0.38 μm. Finally, the biodistribution and activation of PC2 and PC6 were also examined in HT29 tumor‐bearing nude mice. For both compounds, the fluorescence intensity per unit area at the tumor was found to grow gradually during the first 24 h. Whereas the intensity then dropped for PC2, the intensity for PC6 remained steady over the following 6 d, which might have been a result of the enhanced permeability and retention effect arising from the larger molecular mass of the hexameric system.
Oxygen Evolution Activity of Co–Ni Nanochain Alloys: Promotion by Electron Injection
Authors: Yuan Xiaotao , Riaz Muhammad Sohail , Wang Xin , Dong Chenlong , Zhang Zhe , Huang Fuqiang 
Published: January 2018

AbstractMetal alloy nanoparticles have shown promising applications in electrocatalysis. However, the nanoparticles usually suffer from limited charge‐transfer efficiency, which can be solved by preparing one‐dimensional materials. Herein, Co–Ni alloy nanochains are prepared by a direct‐current arc‐discharge method. The nanochains, comprised of mutually coupled uniform nanospheres, can range up to several micrometers in size. When the alloy is exposed to air or under the electro‐oxidation process, a metal–metal‐oxide heterostructure is obtained. The alloy can inject electrons into the oxide, which makes it more suitable for electrocatalysis. The composition of the samples can be changed by varying the ratio of Ni/Co (i.e., Co, Co7Ni3, Co5Ni5, Co3Ni7, Ni) in the synthesis process. The nanochains show good oxygen evolution performance that correlates with the Ni/Co ratio. Co7Ni3 demonstrates optimal activity with an onset point of 1.50 V vs. reversible hydrogen electrode (RHE) and overpotential of 350 mV at 10 mA cm−2. The alloy nanochains also show excellent durability with 95.0 % current retention after a long‐term test for 12 h.
Complexes of Stiboranium Mono‐, Di‐, and Trications
Authors: Frazee Christopher , Burford Neil , McDonald Robert , Ferguson Michael J. , Decken Andreas , Patrick Brian O. 
Published: January 2018

AbstractReaction of Ph2SbCl3 with 2,2′‐bipyridine and Me3SiOSO2CF3 releases chlorobenzene, which is interpreted as a reductive (SbV/SbIII) elimination from a complex of a stiboranium cation. Conversely, reactions of Ph2SbCl3 with 4‐methylpyridine‐N‐oxide and AgOSO2CF3 give redox‐resistant complexes with the generic formulae [Ph2SbCl3−xLx+1][OTf]x, including a compound containing a pnictogen(V) trication.
Selective P−C(sp3) Bond Cleavage and Radical Alkynylation of α‐Phosphorus Alcohols by Photoredox Catalysis
Authors: Jia Kunfang , Li Junzhao , Chen Yiyun 
Published: January 2018

AbstractHerein the first P−C(sp3) bond cleavage and radical alkynylation of α‐phosphorus alcohols to construct phosphonoalkynes is reported. The phosphorus radical is generated upon P−C bond cleavage reaction via the alkoxyl radical through photoredox catalysis with cyclic iodine(III) reagents. Various arylphosphinoyl‐, alkylphosphinoyl‐, phosphonate‐, and phosphonic amide alcohols serve as radical phosphorus precursors to construct phosphonoalkynes for the first time.
Marketing Activities, Strategic Competition, and Firm Value
Authors: Ryoo Juyoun , Lee Cheolwoo , Jeon Jin Q. , Choi Hwanseok Winston 
Published: January 2018

AbstractThis study extends the prior literature on the effect of marketing activities on firm value by investigating whether the nature of strategic competition affects financial outcomes differentially. Using the competitive strategy measure (CSM), we show that marketing spending is beneficial (detrimental) to firm value when the firm is in strategic substitutes (complements) and the efficacy is a decreasing function of the degree of industry competition. The relative competitive position of a firm in the industry—whether it is a leader or a follower—matters in the quality and size of the effect of marketing spending. By bifurcating the nature of strategic competition into strategic substitutes and complements, we disentangle the dichotomous effects of marketing activities on firm value. Copyright © 2018 ASAC. Published by John Wiley & Sons, Ltd.
Target‐Setting, Pay for Performance, and Quality Improvement: A Case Study of Ontario Hospitals’ Quality‐Improvement Plans
Authors: Chan Yee‐Ching Lilian , Hsu Sylvia Hsingwen 
Published: January 2018

AbstractThis study examines whether difficult targets and quality indicators in executives' pay‐for‐performance (P4P) plans affect performance. The impact of target‐setting and P4P plans on quality improvement in the public sector is unclear. The Ontario government initiated the Quality Improvement Plan (QIP), which requires hospitals to set targets for quality indicators annually and link executive pay to target achievement since 2011. Analyzing Health Quality Ontario's database and hospitals' 2012–2013 QIPs, this study shows greater quality improvement in hospitals with difficult targets than hospitals with easy targets or without assigned targets; however, the positive impact disappears for high‐performance hospitals relative to their peers. We find no significant effect of the use of quality indicators in executives' P4P plans on quality improvement. Copyright © 2018 ASAC. Published by John Wiley & Sons, Ltd.
Reassessment of cardiovascular parameters and comorbidities in implantable cardioverter‐defibrillator patients at the time of first replacement
Authors: Wuest Sandra , Twerenbold Raphael , Kühne Michael , Reichlin Tobias , Sticherling Christian , Osswald Stefan , Schaer Beat 
Published: January 2018

BackgroundGuidelines provide extensive recommendations regarding implantable cardioverter‐defibrillator (ICD) implantation. However, ICD replacement at the time of battery depletion is rarely studied.HypothesisOur objectives were to identify patients at high‐risk of death after ICD replacement, with a reassessment of changes in risk factors and comorbidities at the time of replacement, and to determine predictors for subsequent mortality.MethodsPatients undergoing ICD replacement for regular battery depletion were selected from a prospective single‐center ICD registry. Both at implant and replacement, 3 demographic parameters, 9 cardiovascular parameters, 5 comorbidities, and 4 laboratory parameters were collected. Cox proportional hazard analyses were used.ResultsWe included 308 patients who were predominantly male (86%) with a median age at ICD replacement of 66 years. Replacement was performed 65 months (interquartile range, 52–91) after implantation. Median follow‐up after replacement was 41 months, during which 82 patients (27%) died. Multivariable analysis revealed 4 independent predictors of mortality after ICD replacement: age/year (hazard ratio [HR]: 1.05, 95% confidence interval [CI]: 1.03‐1.08, P = 0.01), worsening heart failure by 1 class (HR: 1.53, 95% CI: 1.15‐2.03, P = 0.003), presence of left bundle branch block (HR: 1.98, 95% CI: 1.22‐3.23, P = 0.006), and ICD therapy prior to replacement (HR: 2.22, 95% CI: 1.37‐3.58, P = 0.001). Incorporated into a dichotomous score, they strongly correlated with mortality at 5 years after replacement (5% with 0 parameters, 15% with 1 parameter, and 30%–55% with >2 parameters).ConclusionsFocused reassessment of selected patient characteristics at the time of ICD replacement correlates with subsequent mortality and can impact decision making at this point in time.