bluuebunny/crossref_metadata_2025_split huggingface dataset:
An examination of the effect of aerosolized Permanone insecticide on zebra finch susceptibility to West Nile virus
Authors: Jankowski Mark D. , Moore Murray E. , Hofmeister Erik K. 
Published: July 2017

Abstract

West Nile virus (WNV) is maintained cryptically primarily in avian (passerine) populations, where it is transmitted by Culex spp. mosquitoes. Mosquito-control measures currently include physical activities to reduce mosquito-breeding sites and the application of mosquito larvicides or aerosolized insecticides to kill adults (adulticides) when arboviral diseases such as WNV or Zika virus are detected in mosquito populations. Organochlorine, organophosphorus, carbamate, and pyrethroid insecticides are often used. Previous work suggests an effect of pyrethroids on the immune system in a variety of vertebrates. We examined the effects of exposure to aerosolized Permanone® 30:30 insecticide (permethrin and piperonyl butoxide in soy oil vehicle) at approximately 103 to 106 times potential environmental concentrations on the response of captive zebra finches (Taeniopygia guttata) to experimental challenge with WNV. Compared to vehicle control birds, WNV outcome was unchanged (65% of birds produced a viremia) in the “low” exposure (9.52 ± 3.13 mg/m3 standard deviation [SD] permethrin) group but reduced in the “high” exposure (mean 376.5 ± 27.9 mg/m3 SD permethrin) group (30% were viremic; p &lt; 0.05). After clearing WNV infection, birds treated with Permanone regained less body mass than vehicle-treated birds (p &lt; 0.001). The present study suggests that exposure to aerosolized Permanone insecticide at levels exceeding typical application rates has the potential to not change or to mildly enhance a bird's resistance to WNV. Environ Toxicol Chem 2017;36:3376–3386. Published 2017 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
Contribution of pyrethroids in large urban rivers to sediment toxicity assessed with benthic invertebrates Chironomus dilutus: A case study in South China
Authors: Cheng Fei , Li Huizhen , Qi Hongxue , Han Qian , You Jing 
Published: July 2017

Abstract

The importance of pyrethroids as potential stressors to benthic organisms has gradually become evident in urban creeks; however, the occurrence and toxicity of sediment-associated pyrethroids are rarely studied in large rivers. In this context, 10 sediments from a large urban river (Guangzhou reach of the Pearl River in China) were assessed for pyrethroid occurrence and sediment toxicity to the benthic invertebrate Chironomus dilutus. One half of the sediments exhibited lethality to C. dilutus in a 10-d exposure and all surviving midges showed significant change of enzymatic activity. Moreover, mortality occurred during a 20-d exposure for all the sediments, in accordance with the high hazard quotients to benthic species estimated from pyrethroid residues in sediment. Pyrethroids were detectable in all sediments with the concentrations ranging from 2.43 to 61.2 ng/g dry weight, and permethrin and cypermethrin dominated pyrethroid composition. Acute toxic units for pyrethroids ranged from 0.03 to 0.56 (cypermethrin accounted for 13–81%) and showed a direct relationship with sediment mortality among the midges. This is consistent with the studies on small creeks in Guangzhou in which sediment-bound cypermethrin was found as a main stressor to benthic invertebrates. Comparatively, sediment toxicity and pyrethroid residues in large rivers were significantly lower than those in nearby creeks (urban tributaries). The difference may be partially explained by differing flow rates and water-carrying capacity among waterbodies at different scales; further validation is required. Overall, extensive use of pyrethroids has caused a threat to benthic species not only in small creeks but also in large rivers. Environ Toxicol Chem 2017;36:3367–3375. © 2017 SETAC
Spatial and Temporal Variation of Soil and Water Salinity in the South‐Western and South‐Central Coastal Region of Bangladesh
Authors: Rahman Shahriar , Sarker Md. Rakib Hasan , Mia Md. Younus 
Published: July 2017

AbstractSalinity intrusion is one of the major water‐related problems in the coastal region of Bangladesh. The intention of this study was to discuss the spatial distribution of soil and water salinity with their severity levels using geospatial techniques. The spatial analysis shows about 222 300 ha of new land being affected by various degrees of soil salinity during the last four decades. The analysis revealed that the spatial extent of salinity has been following an increasing trend and the movement of soil salinity has moved north from the coast. An increasing trend of salinity concentration in the rivers has already been found in the Lower Meghna River, Alaipur Khal (creek) of Daratona River, Gorai Madhumati, Rupsa Passur River and Bishkhali River in different districts of coastal Bangladesh. The groundwater is contaminated with a high level of salinity, which affects sources of drinking water, agriculture and the irrigation sector. Increased soil and water salinity levels cause an unfavourable environmental and hydrological situation that restricts usual crop production throughout the year. This research will assist decision makers and planners in taking proper initiatives for developing integrated land and water resources management plans for the coastal regions, which have similar environmental settings along the Bay of Bengal. Copyright © 2017 John Wiley & Sons, Ltd.
Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study
Authors: Karasik David , Demissie Serkalem , Lu Darlene , Broe Kerry E , Boyd Steven K , Liu Ching-Ti , Hsu Yi-Hsiang , Bouxsein Mary L , Kiel Douglas P 
Published: July 2017

ABSTRACT

Genetic factors contribute to the risk of bone fractures, partly because of effects on bone strength. High-resolution peripheral quantitative computed tomography (HR-pQCT) estimates bone strength using micro-finite element analysis (µFEA). The goal of this study was to investigate if the bone failure load estimated by HR-pQCT-based µFEA is heritable and to what extent it shares genetic regulation with areal bone mineral density (aBMD). Bone microarchitecture was measured by HR-pQCT at the ultradistal tibia and ultradistal radius in adults from the Framingham Heart Study (n = 1087, mean age 72 years; 57% women). Radial and tibial failure load in compression were estimated by µFEA. Femoral neck (FN) and ultradistal forearm (UD) aBMD were measured by dual-energy X-ray absorptiometry (DXA). Heritability (h2) of failure load and aBMD and genetic correlations between them was estimated adjusting for covariates (age and sex). Failure load values at the non-weight-bearing ultradistal radius and at the weight-bearing ultradistal tibia were highly correlated (r = 0.906; p &lt; 0.001). Estimates of h2 adjusted for covariates were 0.522 for the radius and 0.497 for the tibia. Additional adjustment for height did not impact on the h2 results, but adjustment for aBMD at the UD and FN somewhat decreased h2 point estimates: 0.222 and 0.380 for radius and tibia, respectively. In bivariate analysis, there was a high phenotypic and genetic correlation between covariate-adjusted failure load at the radius and UD aBMD (ρP = 0.826, ρG = 0.954, respectively), whereas environmental correlations were lower (ρE = 0.696), all highly significant (p &lt; 0.001). Similar correlations were observed between tibial failure load and femoral neck aBMD (ρP = 0.577, ρG = 0.703, both p &lt; 0.001; ρE = 0.432, p &lt; 0.05). These data from adult members of families from a population-based cohort suggest that bone strength of distal extremities estimated by micro-finite element analysis is heritable and shares some genetic composition with areal BMD, regardless of the skeletal site. © 2017 American Society for Bone and Mineral Research.
Effect of Memantine on Serum Levels of Neuron‐Specific Enolase and on the Glasgow Coma Scale in Patients With Moderate Traumatic Brain Injury
Authors: Mokhtari Majid , Nayeb‐Aghaei Hossein , Kouchek Mehran , Miri Mir Mohammad , Goharani Reza , Amoozandeh Arash , Akhavan Salamat Sina , Sistanizad Mohammad 
Published: July 2017

AbstractTraumatic brain injury (TBI) is a major cause of disability and death globally. Despite significant progress in neuromonitoring and neuroprotection, pharmacological interventions have failed to generate favorable results. We examined the effect of memantine on serum levels of neuron‐specific enolase (NSE), a marker of neuronal damage, and the Glasgow Coma Scale (GCS) in patients with moderate TBI. Patients were randomly assigned to the control group (who received standard TBI management) and the treatment group (who, alongside their standard management, received enteral memantine 30 mg twice daily for 7 days). Patients’ clinical data, GCS, findings of head computed tomography, and serum NSE levels were collected during the study. Forty‐one patients were randomized into the control and treatment groups, 19 and 22 patients respectively. Baseline characteristics and serum NSE levels were not significantly different between the 2 groups. The mean serum NSE levels for the memantine and the control groups on day 3 were 7.95 ± 2.86 and 12.33 ± 7.09 ng/mL, respectively (P= .05), and on day 7 were 5.03 ± 3.25 and 10.04 ± 5.72 ng/mL, respectively (P= .003). The mean GCS on day 3 was 12.3 ± 2.0 and 10.9 ± 1.9 in the memantine and control groups, respectively (P= .03). Serum NSE levels and GCS changes were negatively correlated (r= −0.368,P= .02). Patients with moderate TBI who received memantine had significantly reduced serum NSE levels by day 7 and marked improvement in their GCS scores on day 3 of the study.
Comparative study of submerged and surface culture acetification process for orange vinegar
Authors: Cejudo‐Bastante Cristina , Durán‐Guerrero Enrique , García‐Barroso Carmelo , Castro‐Mejías Remedios 
Published: July 2017

AbstractBACKGROUNDThe two main acetification methodologies generally employed in the production of vinegar (surface and submerged cultures) were studied and compared for the production of orange vinegar. Polyphenols (UPLC/DAD) and volatiles compounds (SBSE‐GC/MS) were considered as the main variables in the comparative study. Sensory characteristics of the obtained vinegars were also evaluated.RESULTSSeventeen polyphenols and 24 volatile compounds were determined in the samples during both acetification processes. For phenolic compounds, analysis of variance showed significant higher concentrations when surface culture acetification was employed. However, for the majority of volatile compounds higher contents were observed for submerged culture acetification process, and it was also reflected in the sensory analysis, presenting higher scores for the different descriptors. Multivariate statistical analysis such as principal component analysis demonstrated the possibility of discriminating the samples regarding the type of acetification process. Polyphenols such as apigenin derivative or ferulic acid and volatile compounds such as 4‐vinylguaiacol, decanoic acid, nootkatone, trans‐geraniol, β‐citronellol or α‐terpineol, among others, were those compounds that contributed more to the discrimination of the samples.CONCLUSIONThe acetification process employed in the production of orange vinegar has been demonstrated to be very significant for the final characteristics of the vinegar obtained. So it must be carefully controlled to obtain high quality products. © 2017 Society of Chemical Industry
Temporal Dynamics of Sediment Sources in an Urbanizing Mediterranean Catchment
Authors: Ferreira Carla S.S. , Walsh Rory P.D. , Blake William H. , Kikuchi Ryunosuke , Ferreira António J.D. 
Published: July 2017

AbstractThe identification of sediment sources is important for catchment management, but few studies have been performed in Mediterranean areas. This study uses a multiproxy sediment fingerprinting approach to explore sources and dynamics of fluvial sediments in a rapidly urbanizing Portuguese peri‐urban catchment. X‐ray fluorescence was used to characterize the elemental geochemistry of sediments collected within the stream network after three storm events in 2012 and 2015. A range of statistical techniques, including hierarchical cluster analysis, was used to identify discriminant sediment properties and similarities between fine bed sediment samples of tributaries and downstream sites. Quantification of sediment supply from upstream sub‐catchments was undertaken using established sediment fingerprinting approaches.The geochemistry of the sediments was found to be influenced by both lithology and land‐use changes. In 2012, the sandstone sub‐catchment provided 75% of the <63 μm and 94% of the 63–125 and 125–2000 μm sediment, mostly from an Enterprise Park site undergoing deforestation and construction (covering 5% of the catchment area), with most of the remaining sediment deriving from the construction of a major road (1% of the catchment) in the limestone sub‐catchment. In 2015, planned and accidental retention basins below the Enterprise Park and major road sites, respectively, prevented some sediment from reaching the stream network, thereby reducing their importance as sediment sources. Sediment mobilization in urban areas with paved roads was small in comparison, but characterized by high heavy metal concentrations. The sediment fingerprinting approach adopted shows promise in identification of the main sources of sediments, necessary to underpin improved peri‐urban management strategies. Copyright © 2017 John Wiley & Sons, Ltd.
Economic and Soil Environmental Benefits of Using Controlled‐Release Bulk Blending Urea in the North China Plain
Authors: Zhou Zijun , Shen Yazhen , Du Changwen , Zhou Jianmin , Qin Yusheng , Wu Yuejin 
Published: July 2017

AbstractCrop production must be increased in order to ensure a sustainable food supply for the growing world population. Controlled‐release urea (CRU) improves nutrient use efficiency and saves labor, but its use in crop production is limited due to its high cost. Bulk blending urea (BBU) consists of both CRU and conventional urea and could be an excellent substitute or replacement for CRU. Nevertheless, its economic benefits and soil environment impact are unknown. A 3‐year field experiment was conducted to investigate the effects of two different nitrogen management practices in terms of economic benefits, soil mineral nitrogen availability, aggregate stability, and soil microbial communities. Split applications of conventional urea (UREA) and a single application of BBU were tested on winter wheat (Triticum aestivum L.) and summer maize (Zea mays L.) in the North China Plain between 2010 and 2013. Crop yields were measured after each harvest, and soil environmental parameters were determined after the 3‐year crop sequence. Relative to UREA, BBU significantly increased net revenue, soil inorganic nitrogen concentration, and the functional diversity of the soil microbial community without adverse effects on the soil bacterial community composition. On the other hand, BBU reduced the amount of soil macro‐aggregates and the mean weight diameter value of soil water‐stable aggregates. Although BBU showed great potential for improving wheat–maize cropping systems in the North China Plain, future studies should focus on optimizing the nitrogen dosage and the CRU ratio in BBU to decrease nitrogen leaching, avoid soil aggregate deterioration, and maintain crop yield. Copyright © 2017 John Wiley & Sons, Ltd.
The Economic Impact of Smoke‐Free Policies on Restaurants, Cafés, and Bars: Panel Data Estimates From European Countries
Authors: Pieroni Luca , Salmasi Luca 
Published: July 2017

AbstractIn this paper, we investigate the extent to which the economic outcomes of restaurants, bars, and cafés have been affected by the introduction of anti‐smoking regulations in Europe. We use an unexploited panel database to collect a comprehensive set of information on financial indicators regarding the balance sheets of private and public companies in various economic sectors. The results show that smoke‐free policies did not significantly affect the firms’ economic performance, irrespective of the balance sheet indicators analyzed. Moreover, the results are robust to various econometric specifications and suggest that the recent enforcement of anti‐smoking legislation in Europe has improved public health without a corresponding negative impact on revenues and employment in the hospitality industry.
A rare polyglycine type II‐like helix motif in naturally occurring proteins
Authors: Warkentin Eberhard , Weidenweber Sina , Schühle Karola , Demmer Ulrike , Heider Johann , Ermler Ulrich 
Published: July 2017

AbstractCommon structural elements in proteins such as α‐helices or β‐sheets are characterized by uniformly repeating, energetically favorable main chain conformations which additionally exhibit a completely saturated hydrogen‐bonding network of the main chain NH and CO groups. Although polyproline or polyglycine type II helices (PPII or PGII) are frequently found in proteins, they are not considered as equivalent secondary structure elements because they do not form a similar self‐contained hydrogen‐bonding network of the main chain atoms. In this context our finding of an unusual motif of glycine‐rich PGII‐like helices in the structure of the acetophenone carboxylase core complex is of relevance. These PGII‐like helices form hexagonal bundles which appear to fulfill the criterion of a (largely) saturated hydrogen‐bonding network of the main‐chain groups and therefore may be regarded in this sense as a new secondary structure element. It consists of a central PGII‐like helix surrounded by six nearly parallel PGII‐like helices in a hexagonal array, plus an additional PGII‐like helix extending the array outwards. Very related structural elements have previously been found in synthetic polyglycine fibers. In both cases, all main chain NH and CO groups of the central PGII‐helix are saturated by either intra‐ or intermolecular hydrogen‐bonds, resulting in a self‐contained hydrogen‐bonding network. Similar, but incomplete PGII‐helix patterns were also previously identified in a GTP‐binding protein and an antifreeze protein.
Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events
Authors: Toyserkani Navid Mohamadpour , Jørgensen Mads Gustaf , Tabatabaeifar Siavosh , Jensen Charlotte Harken , Sheikh Søren Paludan , Sørensen Jens Ahm 
Published: July 2017

Abstract
The popularity of adipose-derived cell therapy has increased over the last decade, and the number of studies published annually is growing. However, concerns regarding safety in the setting of previous malignancy or the use of allogeneic cells have been raised. We therefore aimed to systematically review all clinical studies using adipose-derived cell therapy to identify reported adverse events with a special focus on risk of thromboembolic, immunological, and oncological safety concerns. Our systematic search resulted in 70 included studies involving more than 1,400 patients that were treated with adipose-derived cell therapy. Safety assessment method was not described in 32 of the included studies. For studies involving systemic or cardiac administration, one case of pulmonary thromboembolism and cases of both myocardial and cerebral infarctions were described. In the setting of allogeneic cell therapy studies, where the production of specific antibodies toward donor cells was examined, it was noted that 19%–34% of patients develop antibodies, but the consequence of this is unknown. With regard to oncological safety, only one case of breast cancer recurrence was identified out of 121 patients. Adipose-derived cell therapy has so far shown a favorable safety profile, but safety assessment description has, in general, been of poor quality, and only adverse events that are looked for will be found. We encourage future studies to maintain a strong focus on the safety profile of cell therapy, so its safeness can be confirmed.
Auramine O, an incense smoke ingredient, promotes lung cancer malignancy
Authors: Tung Jia‐Chen , Huang Wei‐Chien , Yang Juan‐Cheng , Chen Guan‐Yu , Fan Chi‐Chen , Chien Yu‐Chuan , Lin Pei‐Shan , Candice Lung Shih‐Chun , Chang Wei‐Chao 
Published: July 2017

AbstractBurning incense to worship deities is a popular religious ritual in large parts of Asia, and is a popular custom affecting more than 1.5 billion adherents. Due to incomplete combustion, burning incense has been well recognized to generate airborne hazards to human health. However, the correlation between burning incense and lung cancer in epidemiological studies remains controversy. Therefore, we speculated that some unknown materials in incense smoke are involved in the initiation or progression of lung cancer. Based on this hypothesis, we identified a major compound auramine O (AuO) from the water‐soluble fraction of incense burned condensate using mass spectrometry. AuO is commonly used in incense manufacture as a colorant. Due to thermostable, AuO released from burned incenses becomes an unexpected air pollutant. AuO is classified as a Group 2B chemical by the International Agency of Research on Cancer (IARC), however, the damage of AuO to the respiratory system remains elusive. Our study revealed that AuO has no apparent effect on malignant transformation; but, it dramatically promotes lung cancer malignancy. AuO accumulates in the nucleus and induces the autophagy activity in lung tumor cells. AuO significantly enhances migration and invasive abilities and the in vitro and in vivo stemness features of lung tumor cells through activating the expression of aldehyde dehydrogenase family 1 member A1 (ALDH1A1), and ALDH1A1 knockdown attenuates AuO‐induced autophagy activity and blocks AuO‐induced lung tumor malignancy. In conclusion, we found that AuO, an ingredient of incense smoke, significantly increases the metastatic abilities and stemness characters of lung tumor cells through the activation of ALDH1A1, which is known to be associated with poor outcome and progression of lung cancer. For public health, reducing or avoiding the use of AuO in incense is recommended.