bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new unified approach to determine geocentre motion using space geodetic and GRACE gravity data
Authors: Wu Xiaoping , Kusche Jürgen , Landerer Felix W. 
Published: March 2017

Abstract
Geocentre motion between the centre-of-mass of the Earth system and the centre-of-figure of the solid Earth surface is a critical signature of degree-1 components of global surface mass transport process that includes sea level rise, ice mass imbalance and continental-scale hydrological change. To complement GRACE data for complete-spectrum mass transport monitoring, geocentre motion needs to be measured accurately. However, current methods of geodetic translational approach and global inversions of various combinations of geodetic deformation, simulated ocean bottom pressure and GRACE data contain substantial biases and systematic errors. Here, we demonstrate a new and more reliable unified approach to geocentre motion determination using a recently formed satellite laser ranging based geocentric displacement time-series of an expanded geodetic network of all four space geodetic techniques and GRACE gravity data. The unified approach exploits both translational and deformational signatures of the displacement data, while the addition of GRACE's near global coverage significantly reduces biases found in the translational approach and spectral aliasing errors in the inversion.
Effect of Adipose-Derived Mesenchymal Stem Cell Administration and Mild Hypothermia Induction on Delayed Neuronal Death After Transient Global Cerebral Ischemia
Authors: Chung Tae Nyoung , Kim Jin Hee , Choi Bo Young , Jeong Ju-Yeon , Chung Sung Phil , Kwon Sung Won , Suh Sang Won 
Published: March 2017

Objectives:
Global cerebral ischemia is a cause of poor prognosis after resuscitation from cardiac arrest. Various attempts have been made to minimize global cerebral ischemia but none been more effective than mild hypothermia induction. A few studies have shown the effect of mesenchymal stem cells on global cerebral ischemia, but no studies have compared this effect with mild hypothermia or assessed any possible interaction. We aimed to show the effect of mesenchymal stem cells on delayed neuronal death after global cerebral ischemia and to compare this effect with mild hypothermia.

Design:
Experimental study.

Setting:
Animal research laboratory.

Subjects:
Adult male Sprague-Dawley rats weighing 250–300 g.

Interventions:
Rats were subjected to 7 minutes of transient global cerebral ischemia and randomized into four groups: control, mild hypothermia, injection of human adipose-derived mesenchymal stem cells, and combined application of mild hypothermia and mesenchymal stem cells, along with four sham groups treated identically. Rats were euthanized 7 days after global cerebral ischemia.

Measurements and Main Results:
Degree of neuronal death in hippocampus was significantly higher in control than in other groups. The number of activated microglia was higher in control group than in other groups and was higher in mild hypothermia than shams, mesenchymal stem cells, mild hypothermia/mesenchymal stem cells. Degree of blood-brain barrier disruption and the count of infiltrated neutrophils were significantly higher in control than in other groups. Degree of oxidative injury was significantly higher in control than other groups. It was higher in mild hypothermia than sham groups, mesenchymal stem cells, mild hypothermia/mesenchymal stem cells and was higher in mesenchymal stem cells group than sham groups. Significantly, worse functional results were found in control than in other groups.

Conclusions:
Administration of mesenchymal stem cells after transient global cerebral ischemia has a prominent protective effect on delayed neuron death, even compared with mild hypothermia.
A Quantile Analysis of Plateau and Driving Pressures: Effects on Mortality in Patients With Acute Respiratory Distress Syndrome Receiving Lung-Protective Ventilation*
Authors: Villar Jesús , Martín-Rodríguez Carmen , Domínguez-Berrot Ana M. , Fernández Lorena , Ferrando Carlos , Soler Juan A. , Díaz-Lamas Ana M. , González-Higueras Elena , Nogales Leonor , Ambrós Alfonso , Carriedo Demetrio , Hernández Mónica , Martínez Domingo , Blanco Jesús , Belda Javier , Parrilla Dácil , Suárez-Sipmann Fernando , Tarancón Concepción , Mora-Ordoñez Juan M. , Blanch Lluís , Pérez-Méndez Lina , Fernández Rosa L. , Kacmarek Robert M. 
Published: March 2017

Objectives:
The driving pressure (plateau pressure minus positive end-expiratory pressure) has been suggested as the major determinant for the beneficial effects of lung-protective ventilation. We tested whether driving pressure was superior to the variables that define it in predicting outcome in patients with acute respiratory distress syndrome.

Design:
A secondary analysis of existing data from previously reported observational studies.

Setting:
A network of ICUs.

Patients:
We studied 778 patients with moderate to severe acute respiratory distress syndrome.

Interventions:
None.

Measurements and Main Results:
We assessed the risk of hospital death based on quantiles of tidal volume, positive end-expiratory pressure, plateau pressure, and driving pressure evaluated at 24 hours after acute respiratory distress syndrome diagnosis while ventilated with standardized lung-protective ventilation. We derived our model using individual data from 478 acute respiratory distress syndrome patients and assessed its replicability in a separate cohort of 300 acute respiratory distress syndrome patients. Tidal volume and positive end-expiratory pressure had no impact on mortality. We identified a plateau pressure cut-off value of 29 cm H2O, above which an ordinal increment was accompanied by an increment of risk of death. We identified a driving pressure cut-off value of 19 cm H2O where an ordinal increment was accompanied by an increment of risk of death. When we cross tabulated patients with plateau pressure less than 30 and plateau pressure greater than or equal to 30 with those with driving pressure less than 19 and driving pressure greater than or equal to 19, plateau pressure provided a slightly better prediction of outcome than driving pressure in both the derivation and validation cohorts (p < 0.0000001).

Conclusions:
Plateau pressure was slightly better than driving pressure in predicting hospital death in patients managed with lung-protective ventilation evaluated on standardized ventilator settings 24 hours after acute respiratory distress syndrome onset.
Evidence-Based Principles for Using Technology-Enhanced Learning in the Continuing Professional Development of Health Professionals
Authors: Scott Karen M. , Baur Louise , Barrett Jenny 
Published: March 2017

Abstract:
Increasingly, health professional training involves the use of educational technologies through what is broadly termed “Technology-Enhanced Learning” (TEL). TEL includes hardware, such as computers and mobile devices, and software, such as software applications (apps), learning management systems, and discussion boards. For many years, TEL has formed an integral part of health professional programs and is growing in acceptance, if not expectation, in postgraduate training and continuing education. TEL generally aims to be flexible, engaging, learner focused and interactive, and may involve collaboration and communication. It offers many benefits for learning and teaching, whether used on its own or in conjunction with face-to-face teaching through blended learning. The ubiquity of mobile devices in clinical settings means TEL is ideal for busy clinicians, both as learners and teachers. TEL enables participants to learn at a time and place that is convenient to them, so learners living in geographically dispersed locations can access standardized courses. To realize these potential benefits, we recommend that those developing TEL programs for health professionals take a systematic approach to planning, development, implementation, and evaluation. To that end, we propose 10 principles: clarify purpose and conduct a needs assessment; allocate adequate time and technology; incorporate proven approaches to improve learning; consider the need for a skills component; enable interaction between learners and with others; create different resources for different groups; pilot before implementing; incorporate measures to retain learners; provide opportunities for revision to aid retention; and evaluate learning outcomes, not just satisfaction.
Hyperuricemia is not associated with severity of liver fibrosis in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis
Authors: Jaruvongvanich Veeravich , Ahuja Wasin , Wijarnpreecha Karn , Ungprasert Patompong 
Published: March 2017

Background
Uric acid is a natural antioxidant. Previous studies have suggested a protective role of hyperuricemia against liver fibrosis among patients with nonalcoholic fatty liver disease (NAFLD). However, the results were conflicting.

Methods
MEDLINE and EMBASE databases were searched through August 2016 for studies that investigated the association between hyperuricemia and fibrosis stage among patients with biopsy-proven NAFLD. Pooled odds ratio and 95% confidence interval were calculated using a random-effects model, generic inverse variance method of DerSimonian and Laird. The between-study heterogeneity of effect size was quantified using the Q statistic and I
2.

Results
A total of five observational studies with 749 NAFLD patients were identified. Patients with NAFLD who had hyperuricemia were not significantly more likely or less likely to have advanced liver fibrosis (defined as fibrosis stage of ≥3) compared with patients with NAFLD who had normal serum uric with the pooled odds ratio of 0.72 (95% confidence interval: 0.34–1.53). The statistical heterogeneity was low with an I
2 of 22% (P
heterogeneity=0.27).

Conclusion
Significant protective role of hyperuricemia against the development of advanced liver fibrosis in patients with NAFLD was not observed in this meta-analysis.
Discovery and reporting of clinically-relevant germline variants in advanced cancer patients assessed using whole-exome sequencing
Authors: Zhang Tuo , Romanel Alessandro , Eng Kenneth W. , Rennert Hanna , Tan Adrian Y. , Xue Yaohua , Cyrta Joanna , Mosquera Juan Miguel , Sboner Andrea , Iossifov Ivan , Lipkin Steven M. , Xiang Jenny , Feng Xiaojun , Nelson Peter , Beltran Himisha , Pritchard Colin C. , Rubin Mark A. , Demichelis Francesca , Elemento Olivier 
Published: March 2017

AbstractPurposeIn precision cancer care, WES-based analysis of tumor-normal samples helps reveal somatic alterations but can also identify cancer-associated germline variants important for disease surveillance, treatment choice and cancer prevention. WES can also identify germline secondary findings impacting risk of cardiac, neurodegenerative or metabolic diseases. In patients with advanced cancer, the frequency of reportable secondary findings encountered with WES is not well defined.MethodsTo address this question, we analyzed a cohort of 343 patients with advanced, metastatic cancer for whom we have performed tumor and germline WES interrogating more than 21,000 genes using a CLIA/CLEP approved assay.Results17% of patients in our cohort have one or more reportable germline variants, including patients with pathogenic variants in the BRCA1 and BRCA2 genes. The frequency of non-cancer clinically relevant germline variants (8.8%) was within the range of two control non-cancer cohorts (11.0% and 6.5%). The frequency of variants in cancer-associated genes was significantly higher (p<0.0005) in our advanced cancer cohort (8.2%) compared to control cohorts (2.7% and 3.8%). More than 50% of patients with reportable germline cancer variants had a family history of cancer.Conclusionthese results stress the importance of returning germline results found during somatic genomic tumor testing.
Time-delayed biodiversity feedbacks and the sustainability of social-ecological systems
Authors: Lafuite A.-S. , Loreau M. 
Published: March 2017

AbstractThe sustainability of coupled social-ecological systems (SESs) hinges on their long-term ecological dynamics. Land conversion generates extinction and functioning debts, i.e. a time-delayed loss of species and associated ecosystem services. Sustainability theory, however, has not so far considered the long-term consequences of these ecological debts on SESs. We investigate this question using a dynamical model that couples human demography, technological change and biodiversity. Human population growth drives land conversion, which in turn reduces biodiversity-dependent ecosystem services to agricultural production (ecological feedback). Technological change brings about a demographic transition leading to a population equilibrium. When the ecological feedback is delayed in time, some SESs experience population overshoots followed by large reductions in biodiversity, human population size and well-being, which we call environmental crises. Using a sustainability criterion that captures the vulnerability of an SES to such crises, we show that some of the characteristics common to modern SESs (e.g. high production efficiency and labor intensity, concave-down ecological relationships) are detrimental to their long-term sustainability. Maintaining sustainability thus requires strong counteracting forces, such as the demographic transition and land-use management. To this end, we provide integrative sustainability thresholds for land conversion, biodiversity loss and human population size - each threshold being related to the others through the economic, technological, demographic and ecological parameters of the SES. Numerical simulations show that remaining within these sustainable boundaries prevents environmental crises from occurring. By capturing the long-term ecological and socioeconomic drivers of SESs, our theoretical approach proposes a new way to define integrative conservation objectives that ensure the long-term sustainability of our planet.
Digital description model of a three-dimensional arrangement structure of conductive fiber of electromagnetic shielding fabric
Authors: Wang Xiuchen , Li Yaping , Su Ying , Pan Zhen , Liu Zhe 
Published: March 2017

Purpose
The three-dimensional arrangement structure of the conductive fiber is an important factor of the shielding effectiveness of the electromagnetic shielding fabric (EMSF). However, until now, the three-dimensional arrangement structure has not been described because of the complex structure, which leads to many difficulties for the subsequent analysis of the electromagnetic characteristics. Therefore, the purpose of this paper is to propose a feature extraction method to describe the arrangement structure of the conductive fiber based on the three-dimensional calibration and image processing technology, providing a new idea for the above problem.

Design/methodology/approach
First, the three-dimensional positions of the conductive fibers in the EMSF are calibrated using the VHX-600 3D digital microscope and the MATLAB7.5 software. The arrangement characteristics of the conductive fibers are analyzed, and equivalent twist, cross-sectional content, and average angle of a single fiber are proposed to describe the arrangement characteristic of the conductive fiber. Then, a digital description model of the conductive fiber is constructed according to the feature parameters and its three-dimensional structures are reproduced using CATIA. Finally, the reliability of the model is verified by an FDTD example, and the significance and application of the model are given.

Findings
The proposed method can provide the feature extraction and description for the complex spatial three-dimensional arrangement structure of conductive fibers. The feature parameters can reflect different micro arrangement features of the conductive fiber. The proposed idea and method can provide a solid foundation for subsequent studies of the electromagnetic properties of the EMSF.

Originality/value
The study in this paper is of great significance and academic value. This paper provides a new three-dimensional calibration method and constructs multiple feature parameters to describe the complex three-dimensional arrangement structure, providing a new effective method to overcome the problem of the conductive fiber description. The proposed method provides an important basis for the shielding mechanism, transmission characteristics, electromagnetic calculation and product design, and woven technology of the EMSF.
Intumescent flame retardant finishing of polyester fabrics via the layer-by-layer assembly technique
Authors: Wattanatanom Warunee , Churuchinda Sireerat , Potiyaraj Pranut 
Published: March 2017

Purpose
The purpose of this paper is to investigate the potential use of the layer-by-layer (LbL) assembly as an intumescent flame retardant for polyester, cotton and their blended fabrics.

Design/methodology/approach
In this study, polyester (PET), cotton and their blends were applied with the flame retardant coating via the LbL assembly technique. The flame retardancy, melt dripping, thermal properties and morphology of coated polyester fabrics were then examined.

Findings
The scanning electron micrograph of uncoated and coated fabrics revealed that the LbL assembly coating on the fabric surface was successful. The assessment of the flame retardancy and thermal properties of the coated fabrics showed that the after-flame time and melt dripping during the vertical burning test decreased. The char residue at temperatures ranging from 450 to 800°C during thermogravimetric analysis was enhanced as compared with the uncoated fabric. Furthermore, the morphology of the char residual of coated fabrics was rougher and bulkier than the uncoated fabrics, suggesting the typical behavior of intumescence.

Social implications
The LbL technique generally uses much fewer chemicals, thus making this flame retardant finishing much more environmentally friendly. It is also expected that these fabrics will show better touch characteristics. These fabrics may be tested for their comfort compared to that of conventional coating to enable their use on an industrial scale.

Originality/value
This work demonstrated the ability to apply an effective intumescent coating on polyester, cotton and blend fabric. In order to maintain fabric handle property, the Lbl coating technique is also employed.
Weft-knitted lace fabric simulation based on the spring-mass model
Authors: Cong Honglian , Lei Hui , Zhang Yongchao , Zhang Aijun , Ma Pibo 
Published: March 2017

Purpose
The obtained simulation structures could reflect the appearances and the features of the fabrics. The purpose of this paper is to promote a lot for design and manufacturing of weft-knitted lace fabrics (WKLF).

Design/methodology/approach
The advantages of WKLF compared with warp-knitted ones were displayed. The formation mechanism of the WKLF was analyzed with employing the mechanics principles. Spring-mass model was proposed in this paper to achieve the simulation of the fabrics. End mass points and intermediate mass points were involved in the model. The displacement of end mass points was considered the dominance and the foundation to settle the positions of all the mass points.

Findings
A novel jacquard lace style fabric with pattern-background effect knitted on circular knitting machine were put forward, which were different from the traditional lace fabrics manufactured on the warp knitting machines.

Originality/value
First, as the manufacturing equipment, circular knitting machine costs much less than warp knitting machine; second, the elastic performance along weft direction of WKLF is more excellent than that of warp-knitted ones. Third, the excellent extensibility gives nice comfort; furthermore, long floating threads do not exist on the WKLF surface, so that the snag will be avoided.
Daily use of time, personal characteristics and experienced well-being
Authors: Ayala Edgardo , Flores David , Quintanilla Claudia , Castaño Raquel 
Published: March 2017

PurposeThis paper aims to seek to provide a more comprehensive view of the determinants of experienced well-being by incorporating personal characteristics suggested to be significant predictors of global well-being, such as income, materialism, religiosity, community mindedness and sleep quality (Dieneret al., 1999; Frey and Stutzer, 2002), as well as time-use activities (Kahneman and Krueger, 2006) and contextual elements, such as day of the week (Csikszentmihalyi and Hunter, 2003; Kahnemanet al., 2004a) and the presence of companions, into a single model of predictive experienced well-being using the day reconstruction method (Kahnemanet al., 2004a).Design/methodology/approachThe authors applied the day reconstruction method to a sample of 1,823 episodes from 104 undergraduate students at a private university in Mexico to determine time assignment and emotional experience. Data were analyzed using a panel data regression model.FindingsIt is currently accepted that experienced well-being depends on how people assign their time; however, the results suggest marginal and interaction effects between time assignment and sharing activities with others. Individuals experience an increase in well-being when any activity is done with others, independent of the valence or the duration of the activity. Also, while money does not produce higher well-being, the share of the budget that is spent with others does cause people to experience more well-being. Finally, the results indicate that personal characteristics are equally important to experienced well-being.Research limitations/implicationsThe sample was restricted to students; thus, to achieve external validity, it is necessary to replicate this analysis within different populations as well as groups of different ages and occupations.Originality/valueThe authors provided an integrative model of experienced well-being that combines personal characteristics, time assignment and contextual factors. In addition, this model provides a more accurate gauge of the impact of personal characteristics on well-being than previous studies by controlling for time assignment and by measuring the impact on experienced, rather than global, well-being.
Clove and cinnamon essential oils in dulce de leche
Authors: Antigo Jessica , Cestari Lucineia , Scapim Monica , Siqueira dos Santos Suelen , Feniman Moritz Cristiane , Madrona Grasiele Scaramal 
Published: March 2017

Purpose
The purpose of this study was to analyze lipid oxidation and microbiological, physical, chemical and sensory attributes of dulce de leche.

Design/methodology/approach
Dulce de leche samples were produced from various essential oil (EOs), control (no EO), clove, cinnamon and a clove and cinnamon mixture. After manufacturing, the products were stored at 25°C for 210 days. During storage, the samples were analyzed for texture, color, protein, lipids, lipid oxidation, pH, moisture, ash and enumeration of Salmonella sp., coliforms at 45°C, Staphylococcus sp. coagulase positive and mesophilic bacteria. The sensory analysis used a hedonic scale for appearance, smell, taste and texture attributes and overall acceptance.

Findings
The addition of EOs (clove and cinnamon) did not alter (p > 0.05) the proximal composition, texture, color or sensory attributes of dulce de leche. All products presented a good acceptance rate (>70 per cent). However, among the samples containing EO, dulce de leche with cinnamon presented a higher acceptance (81.67 per cent), and after 210 days of storage, it had lower (40.9 μg malonaldehyde/g p-value <0.01) lipid oxidation. Microbiological analyses indicated that the EOs are active antimicrobial components and are viable inclusions in this type of product.

Originality/value
The inclusion of EOs in dulce de leche provided an overall sensory acceptance similar to the traditional product and all products, including the control, were comparable. Dulce de leche produced with EOs is marketable.