bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting apolipoprotein C-III: a game changer for pancreatitis prevention in severe hypertriglyceridemia
Authors: Weijs Bram M. , Oostveen Reindert F. , Kraaijenhof Jordan M. , Stroes Erik S.G. 
Published: February 2025

Purpose of review
The aim of this review is to examine recent advancements in RNA-targeted therapies for the management of severe hypertriglyceridemia (sHTG) and prevention of sHTG-associated acute pancreatitis.

Recent findings
Recent developments in RNA-targeted therapies, aimed at inhibiting apolipoprotein C-III (apoC-III), have demonstrated substantial and sustained reductions in triglyceride levels. Novel therapies, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA), such as volanesorsen, olezarsen, and plozasiran, have shown promising results in recent trials. These therapies not only effectively lower plasma triglyceride levels but also significantly reduce the incidence of acute pancreatitis.

Summary
SHTG is a high-burden metabolic disorder that is associated with a significantly increased incidence and severity of acute pancreatitis. Traditional lifestyle interventions and conventional therapies, including fibrates and n-3 fatty acids, often provide only modest reductions in triglycerides and fail to prevent sHTG-associated acute pancreatitis. The emergence of novel and targeted RNA-therapies represents a potential breakthrough in the management of sHTG and acute pancreatitis prevention.
Taking a Closer Look at Incivility in Prelicensure Nursing Education
Authors: Weaver Rebecca , Evans Michael , Hrabovsky Sharilee , Loeb Susan 
Published: February 2025

Background:
Incivility in undergraduate nursing education is a complex, multifaceted issue. Student-to-faculty incivility can be characterized by behaviors that negatively impact the faculty’s ability to perform and enjoy their job.

Purpose:
To synthesize current research in undergraduate nursing education about student-to-faculty incivility in the classroom setting.

Methods:
A narrative review was performed on literature from 5 databases and retrieved articles’ reference lists. Relevant articles from 2018 through January 2, 2025, were reviewed.

Results:
Thematic analysis of 16 articles identified 4 key themes: (1) types of incivility, (2) causes of and influences on incivility, (3) consequences of incivility, and (4) strategies for addressing and mitigating incivility.

Conclusion:
Student-to-faculty incivility contributes to many negative consequences in academia including decreased faculty retention and continuance of incivility into practice. Targeted interventions and institutional strategies should be developed to mitigate these behaviors.
Ten-Year Trends in How Early-Stage Sepsis Start-Ups Receive Investment
Authors: Younger John G , Jordan Jacob , Kaido Shintaro 
Published: February 2025

Abstract
Often initiated with small governmental or philanthropic grants, nearly all improvements in the detection and care of sepsis require many years and many millions of dollars of financing before becoming generally clinically available. As early-stage healthcare investors are free to pursue a wide variety of new enterprises, innovations in sepsis care must compete in the early investment marketplace by offering both a path to clinical benefit and a path to commercial viability upon commercialization. In this note, we consider the investment environment for sepsis-related technologies including pharmaceuticals and biologicals, diagnostic and therapeutic devices, and health care information technologies and place a decade of investment trends into a broader economic context. Our hope is to better familiarize basic, translational, and clinical scientists with greater insight into how their inventions will be supported as they make their way to the bedside.
Resonant capture of Saturn’s arcs
Authors: El Moutamid M. , Sicardy B. , Renner S. , Souami D. 
Published: February 2025

Obtained images from the Cassini spacecraft have unveiled several small satellites in the vicinity of Mimas’ orbit: Aegaeon, Methone and Anthe. Methone and Anthe are situated within arcs of material, while Aegaeon orbits within an arc near the inner edge of Saturn’s G ring. The presence of these arcs and moons is consistent with their confinement by corotation eccentric resonance (CER) with Mimas. Aegaeon is captured in an inner 7 : 6 mean motion resonance with Mimas, while Methone and Anthe are, respectively, captured in outer 14 : 15 and 10 : 11 resonances with Mimas. Here, we estimate the probabilities of capturing these small satellites into their respective CERs with Mimas as the orbit of the latter evolves through tidal effects. We will discuss the potential implications of this work, in particular the constraints it may provide on Mimas’ orbital evolution.
This article is part of the theme issue ‘Major advances in planetary sciences thanks to stellar occultations’.
Investigating the formation of small Solar System objects using stellar occultations by satellites: present, future and its use to update satellite orbits
Authors: Braga-Ribas F. , Vachier F. , Desmars J. , Margoti G. , Sicardy B. 
Published: February 2025

The history of the outer solar system is intrinsically related to the Giant Planets migration. A massive disk of material within a radius of 30 au was scattered during the planetary migration, creating different dynamic populations in the Transneptunian region. They were formed in a collisional environment when massive collisions allowed them to grow and form much smaller moons than the primary body. The dynamical group, known as the Cold Classicals, was formed in a sparse disk from 42 to about 47 au and did not suffer much from planet migration. Observations show that many of Cold Classical are binary, consistent with the streaming instability process. The stellar occultation technique, with a spatial resolution of a few kilometres, can be used to search for binaries where other techniques are unable to do so, and to characterize the known satellites of Trans-Neptunian Objects (TNO), constraining their formation scenarios. We review here the first stellar occultations by TNO’s satellites (besides Charon), and discuss the methods used to detect these events. We also fit new orbital elements and system mass for Vanth (Orcus/1) and Weywot (Quaoar/1), finding reasonable solutions for pure Keplerian orbits. Finally, we discuss the prospects regarding the stellar occultations by TNO binaries and their implications for the study of the history of the Solar System.
This article is part of the theme issue ‘Major advances in planetary sciences thanks to stellar occultations’.
Genome-wide association study provides novel insight into the genetic architecture of severe obesity
Authors: Krishnan Mohanraj , Anwar Mohammad Yaser , Justice Anne E , Chittoor Geetha , Chen Hung-Hsin , Roshani Rashedeh , Smit Roelof A.J , Preuss Michael H , Chami Nathalie , Hadad Benjamin S , Parra Esteban J , Cruz Miguel , Hui Qin , Wilson Peter W.F , Sun Yan V , Zhang Xiaoyu , Linchangco Gregorio V , Kardia Sharon L.R , Faul Jessica D , Weir David R , Bielak Lawrence F , Highland Heather M , Young Kristin L , Qi Baiyu , Wang Yujie , Fornage Myriam , Haiman Christopher , Cheng Iona , Peters Ulrike , Kooperberg Charles , Buyske Steven , McCormick Joseph B , Fisher-Hoch Susan P , Lona-Durazo Frida , Peralta Jesus , Gomez-Zamudio Jamie , Rich Stephen S , Ferrier Kendra R , Lange Ethan M , Gignoux Christopher G , Kenny Eimear E , Wojcik Genevieve L , Cho Kelly , Gaziano Michael J , Djousse Luc , Liu Shuwei , Vaidya Dhananjay , de Mutsert Renée , Josyula Navya S , Bauer Christopher R , Zhao Wei , Walker Ryan W , Smith Jennifer A , Lange Leslie A , Meyer Mariah C , Liu Ching-Ti , Yanek Lisa R , Lee Miryoung , Raffield Laura M , Loos Ruth J.F , Gordon-Larsen Penny , Below Jennifer E , North Kari E , Graff Mariaelisa 
Published: February 2025

ABSTRACTSevere obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limiting knowledge about its mechanisms and impacts. In genome-wide association study (GWAS) meta-analyses of the tail end of the BMI distribution (≥95thpercentile BMI) and two SevO phenotypes [Obesity Class III BMI ≥40 kg/m2and Obesity Class IV BMI ≥50 kg/m2] in 159,359 individuals across eleven ancestrally diverse population-based studies followed by replication in 480,897 individuals across six ancestrally diverse studies, we identified and replicated one novel signal in an unknown locus [BHLHE40-AS1] and three novel signals in known loci of BMI [TENM2,PLCL2,ZNF184], associated with SevO traits. We confirmed a large overlap in the genetic architecture of continuous BMI and severe obesity phenotypes, suggesting little genetic heterogeneity in common variants, between obesity subgroups. Systematic analyses combining functional mapping, polygenic risk scores (PRS), phenome wide association studies (PheWAS) and environmental risk factors further reinforce shared downstream comorbidities associated with continuous measures of BMI and the importance of known lifestyle factors in interaction with genetic predisposition to SevO. Our study expands the number of SevO signals, demonstrates a strong overlap in the genetic architecture of SevO and BMI and reveals a remarkable impact of SevO on the clinical phenome, affording new opportunities for clinical prevention and mechanistic insights.
Subleading logarithmic behavior in the parquet formalism
Authors: Gievers Marcel , Schmidt Richard , von Delft Jan , Kugler Fabian B. 
Published: February 2025

The Fermi-edge singularity in x-ray absorption spectra of metals is a paradigmatic case of a logarithmically divergent perturbation series. Prior work has thoroughly analyzed the leading logarithmic terms. Here, we investigate the perturbation theory beyond leading logarithms and formulate self-consistent equations to incorporate all leading and next-to-leading logarithmic terms. This parquet solution of the Fermi-edge singularity goes beyond the previous first-order parquet solution and sheds new light on the parquet formalism regarding logarithmic behavior. We present numerical results in the Matsubara formalism and discuss the characteristic power laws. We also show that, within the single-boson exchange framework, multi-boson exchange diagrams are needed already at the leading logarithmic level.

Published by the American Physical Society
2025
Fully charmed P-wave tetraquark resonant states in the quark model
Authors: Wu Wei-Lin , Zhu Shi-Lin 
Published: February 2025

We conduct the first comprehensive P-wave four-body dynamical calculations of the fully charmed tetraquark systems within the quark potential model. We apply the Gaussian expansion method to solve the four-body Schrödinger equation, incorporating both dimeson and diquark-antidiquark spatial configurations. The matrix elements of P-wave states are calculated analytically using the infinitesimally shifted Gaussian basis functions. With the complex scaling method, we obtain several fully charmed P-wave resonant states with compact tetraquark configuration in the mass region of (7.0, 7.2) GeV, including states with exotic quantum numbers JPC=0−−,1−+. However, we find no resonant states with the mass M<7  GeV and width Γ<200  MeV. Combining the present investigation with our previous results on S-wave fully charmed tetraquark systems [, ], we find no candidates for the experimental states X(6400) and X(6600) in the quark model.

Published by the American Physical Society
2025
How fast can protons decay?
Authors: Davoudiasl Hooman , Denton Peter B. 
Published: February 2025

Current laboratory bounds imply that protons are extremely long-lived. However, this conclusion may not hold for all time and in all of space. We find that the proton lifetime can be ∼15 orders of magnitude shorter in the relatively recent past on Earth or at the present time elsewhere in the Milky Way. A number of terrestrial and astrophysical constraints are examined and potential signals are outlined. We also sketch possible models that could lead to spatial or temporal variations in the proton lifetime. A positive signal could be compelling evidence for a new long range force of nature, with important implications for the limitations of fundamental inferences based solely on laboratory measurements.

Published by the American Physical Society
2025
An integrated aircraft scheduling model based on flight delay propagation and improved column generation algorithm
Authors: Jia Yingze , Wang Chaofeng 
Published: February 2025

Purpose
This paper aims to reduce flight delay propagation, improve flight punctuality rate and ensure aircraft maintenance opportunities by establishing an integrated aircraft scheduling model, aiming at minimizing the total propagated delay and direction operational cost.

Design/methodology/approach
In this paper, flight data sets are obtained through automatic dependent detection broadcast. To accurately predict flight delay time, the flight delay prediction eXtreme gradient boosting model adds the data set obtained by random forest advance model learning and predicts the newly generated flight delays. Finally, based on the forecast results, the flight plan can be optimized and adjusted by using the improved column generation algorithm.

Findings
It is verified by the actual weekly planned operation data of an airline company, experiments show that the model established in this paper can reduce flight delay propagation by 30% in case tests and each aircraft has the opportunity to be repaired at the base airport.

Originality/value
Optimize the aircraft scheduling plan, cover a wide range of data, not just a single route and airport, supplement the gap in the aircraft scheduling plan based on weather factors to predict flight delays.
Structural transformation and sustainable development in sub-Saharan Africa
Authors: Olaoye Olumide O. , Zerihun Mulatu Fekadu , Tabash Mosab I. 
Published: February 2025

PurposeThe study investigates the link between structural transformation and sustainable development in sub-Saharan Africa.Design/methodology/approachThe study adopts the traditional ordinary least square method and the Driscoll and Kraay covariance matrix estimator to address every form of cross-sectional and temporal dependence in panel data.FindingsThe study finds the structural transformation of the SSA economy will engender sustainable development. Specifically, the study finds that knowledge exerts a positive and statistically significant impact on sustainable development in SSA. Similarly, we found that technology (mobile cellular subscription and fixed telephone line subscription) promotes sustainable development. The results also show that all the economic transformation promotes sustainable development in SSA. Further, we also found that economic development and physical capital are important drivers of sustainable development in SSA. However, trade openness does not contribute to sustainable development in SSA. This might be because the combined scale effect in trade outweighs the combined technology and composition effects in SSA. This suggests the technology component in total trade activities in SSA does not promote sustainable development. The study recommends that governments across SSA should invest more in ICT and mobile cellular infrastructure or create an enabling environment that encourages digitization and the development of financial technology in the manufacturing, mining, construction, agriculture and services sectors to enhance green and quality growth for sustainable development in SSA.Originality/valueThe study uncovers the role of structural transformation in promoting sustainable development in SSA.
Spirit of place and brand equity: culinary tourism through a Confucian lens
Authors: Cheng Li , Wang Yunlang , Wang Meiyu , Ju Yingying , Li Jun , Wall Geoffrey 
Published: February 2025

PurposeThis study explores the interplay between the spirit of place, brand equity and tourists’ travel intentions within the context of culinary tourism at destinations influenced by Confucian culture. It examines how Confucian values, such as benevolence, righteousness, courtesy, wisdom and trust, shape the personality of culinary tourism destinations and how this personality influences tourists’ travel intentions both directly and indirectly through brand equity.Design/methodology/approachThe researchers develop a conceptual framework highlighting dimensions of destination personality derived from Confucian values. These values serve as indicators of brand equity, focusing on dimensions like brand image, perceived quality and brand loyalty in the culinary tourism sector. Partial least squares structural equation modeling (PLS-SEM) was employed to analyze data from 503 tourists, examining the relationships between the Confucian-inspired destination personality, brand equity and tourists’ travel intentions.FindingsThe results show that tourists resonate strongly with the five Confucian personality traits, which significantly influence their travel intentions either directly or indirectly through enhanced brand equity. The study highlights the pivotal role of Confucian culture in shaping the destination personality and brand equity, which, in turn, drives tourists’ travel behaviors.Practical implicationsThis study reveals how the spirit of place influences tourist behavior through brand equity, providing new perspectives and practical strategies for destination branding and development.Originality/valueThis study is the first to examine the relationships between spirit of place, brand equity and travel intentions within a Confucian cultural context, expanding the theoretical understanding of culinary tourism branding.
Navigating knowledge hiding: perspectives from hiders and targets in group settings
Authors: Tokyzhanova Talshyn , Durst Susanne 
Published: February 2025

Purpose
This study aims to investigate the dynamics of knowledge hiding (KH) within group settings, focusing on both the experiences of those who hide knowledge and the perceptions of their group members.

Design/methodology/approach
An exploratory study was conducted with 49 undergraduate business students who participated in group-based problem-solving tasks. Some participants were assigned the role of “knowledge hiders.” Data were gathered through observations, pre- and posttask surveys and in-depth interviews. The analysis included quantitative and qualitative approaches, with thematic analysis applied to the qualitative data.

Findings
This study identified complex emotional responses among knowledge hiders, including guilt and cognitive conflict, moderated by social context. Hiders used various strategies, including evasive hiding, playing dumb and misdirection. Interestingly, targets often misinterpreted KH behaviors, attributing them to disinterest or discomfort rather than intentional withholding.

Research limitations/implications
The controlled setting and short-term interactions may limit generalizability to organizational contexts. Future research should explore the long-term consequences of KH and its occurrence in diverse environments.

Practical implications
Organizations may benefit from addressing the underlying causes of KH, such as communication issues and weak social connections, rather than solely focusing on eliminating KH behaviors. Understanding the subtle nature of KH could lead to more effective interventions in fostering open knowledge-sharing cultures.

Originality/value
The dual perspective – examining both the hiders’ and targets’ experiences – adds a novel dimension to the KH literature. The findings challenge the assumption that KH always leads to negative outcomes, like mistrust or group conflict, and emphasize how KH is often misperceived in group interactions.
Advancing management scholarship internationally through theoretical emancipation
Authors: Cao Ke , Tong Li , Du Yongzhi 
Published: February 2025

PurposeAn increasing consensus has been built on advancing management scholarship in contexts other than Anglophone North America. However, debates and arguments about how to do so remain, and there has not been a clear understanding of the progress made. This study aims to conduct a comprehensive and historical assessment of related scholarship and provide recommendations for the path forward.Design/methodology/approachAround 2,700 international context-based empirical papers published from 1990 to 2020 in 4 elite general management journals were reviewed. Other relevant publications on the margins and related academic discussions were also analyzed.FindingsAt elite outlets, international-context-based research is characterized by a gradual decrease in intellectual vigor and methodological variety, a disregard for context and indifference to practice. At outlets on the edge, research is less constrained by dominant and rigid academic discourse.Research limitations/implicationsThe paper prioritizes liberatory thinking about theoretical contribution as the key solution for the academic impasse. Extant theories shall be conceptualized as context-bounded heuristics rather than universal truths. Additional provocations and suggestions about reforming research practice were provided.Originality/valueThe study is the first comprehensive literature survey in this area. Meanwhile, new, grounded and provocative recommendations have been outlined for a bold and robust reset of academic discourse.
Network heterogeneity, social stressors and social media fatigue: a person-environment misfit perspective
Authors: Yang Hongjun , Hu Xu 
Published: February 2025

Purpose
Social media-induced fatigue has received much attention in recent years. Although studies have discussed the association between related stress and fatigue, few studies have analyzed the media characteristics corresponding to social interaction stress and their effects on fatigue from the perspective of social relations and interaction structure. This paper aims to explore the association between network heterogeneity, social stressors and fatigue from the perspective of a person-environment misfit.

Design/methodology/approach
The survey data of 402 social media users were analyzed, and hierarchical regression models were used to validate the proposed theoretical model.

Findings
Data analysis showed that supplementary misfits (network heterogeneity) and complementary misfits (information overload and role conflict) positively affect fatigue. Additionally, supplementary misfits can indirectly affect fatigue through complementary misfits. The analysis results also confirmed the positive moderating effect of the relationship climate between network heterogeneity and role conflict. However, the quality of information does not reduce the impact of network heterogeneity on information overload.

Originality/value
This study reveals the mechanisms affecting user fatigue due to a lack of match with the environment. It also provides evidence of stress self-regulation among social media users and suggests how managers can help alleviate it.