bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE FAILURE OF UNIVERSAL THEORIES OF TORT LAW
Authors: Goudkamp James , Murphy John 
Published: September 2016

ABSTRACTMany scholars have offered theories that purport to explain the whole of the law of torts. At least some of these theories do not seem to be specific to a single jurisdiction. Several appear to endeavor to account for tort law in at least the major common law jurisdictions or even throughout the common law world. These include Ernest Weinrib's corrective justice theory, Robert Stevens's rights theory, and Richard Posner's economic theory. This article begins by explaining why it is appropriate to understand these three theories as universal theories of tort law and why it is important that they be so understood. This explanation draws upon various overt claims (or other strong intimations) made by the theorists themselves to the effect that this is how their respective accounts should be understood. The article then proceeds to test these theories, all of which are leading accounts of tort law, against the evidence in Australia, Canada, the United Kingdom, and the United States. The parts of tort law on which we focus are (1) the breach element of the action in negligence, (2) the law that determines when a duty of care will be owed in respect of pure economic loss, (3) the law that governs the availability of punitive damages, (4) the defense of illegality, and (5) the rule in Rylands v. Fletcher and its descendants. The article concludes that none of the theories is a satisfactory universal account of tort law. All of them suffer from significant problems of fit in that they cannot accommodate (often even approximately) the areas of law that we discuss. Although each of the theories contains a great many valuable insights, they all nonetheless fall well short of accomplishing that which they are held out as providing. In the course of this analysis, the article explains why this is an appropriate line of criticism and identifies the degree of lack of fit that we regard as being “significant.”
Assessing the relative validity of the Scottish Collaborative Group FFQ for measuring dietary intake in adults
Authors: Hollis Jenna L , Craig Leone CA , Whybrow Stephen , Clark Heather , Kyle Janet AM , McNeill Geraldine 
Published: September 2016

AbstractObjectiveTo assess the relative validity of the latest version of the Scottish Collaborative Group (SCG) FFQ (version 6.6) in adults living in Scotland.DesignA cross-sectional validation study. Participants completed the self-administered, 169-item SCG FFQ followed by a 7 d, non-weighed food diary. Energy and energy-adjusted macronutrients and micronutrients were examined for relative validity through Spearman’s correlation, the percentage of classification into thirds of intake, Cohen’s weighted kappa (κw) and Bland–Altman analysis.SettingGeneral population living in Scotland.SubjectsNinety-six adults aged 18–65 years.ResultsSpearman’s correlation coefficients ranged from 0·21 (retinol) to 0·71 (Mg). A median of 52 % of adults were correctly classified into thirds of intake (range: 42 % (PUFA, MUFA and Fe) to 64 % (percentage energy from carbohydrates)) and 8 % were grossly misclassified into opposite thirds of intake (range: 3 % (carbohydrates, percentage energy from carbohydrates) to 19 % (thiamin)). Values of κw ranged between 0·20 (PUFA, β-carotene) to 0·55 (percentage energy from carbohydrates). In the Bland–Altman analysis, the smallest limits of agreement, when expressed as a percentage of the mean intake from the FFQ and food diary, were seen for the main macronutrients carbohydrates, fat and protein.ConclusionsAs in the previous validation study more than 10 years ago, the FFQ gave higher estimates of energy and most nutrients than the food diary, but after adjustment for energy intake the FFQ could be used in place of non-weighed food diaries for most macronutrients and many micronutrients in large-scale epidemiological studies.
Seasonal variation of food security among the Batwa of Kanungu, Uganda
Authors: Patterson Kaitlin , Berrang-Ford Lea , Lwasa Shuaib , Namanya Didacus B , Ford James , Twebaze Fortunate , Clark Sierra , Donnelly Blánaid , Harper Sherilee L 
Published: September 2016

AbstractObjectiveClimate change is projected to increase the burden of food insecurity (FI) globally, particularly among populations that depend on subsistence agriculture. The impacts of climate change will have disproportionate effects on populations with higher existing vulnerability. Indigenous people consistently experience higher levels of FI than their non-Indigenous counterparts and are more likely to be dependent upon land-based resources. The present study aimed to understand the sensitivity of the food system of an Indigenous African population, the Batwa of Kanungu District, Uganda, to seasonal variation.DesignA concurrent, mixed methods (quantitative and qualitative) design was used. Six cross-sectional retrospective surveys, conducted between January 2013 and April 2014, provided quantitative data to examine the seasonal variation of self-reported household FI. This was complemented by qualitative data from focus group discussions and semi-structured interviews collected between June and August 2014.SettingTen rural Indigenous communities in Kanungu District, Uganda.SubjectsFI data were collected from 130 Indigenous Batwa Pygmy households. Qualitative methods involved Batwa community members, local key informants, health workers and governmental representatives.ResultsThe dry season was associated with increased FI among the Batwa in the quantitative surveys and in the qualitative interviews. During the dry season, the majority of Batwa households reported greater difficulty in acquiring sufficient quantities and quality of food. However, the qualitative data indicated that the effect of seasonal variation on FI was modified by employment, wealth and community location.ConclusionsThese findings highlight the role social factors play in mediating seasonal impacts on FI and support calls to treat climate associations with health outcomes as non-stationary and mediated by social sensitivity.
The Relationship Between Quality of Sleep and Emotional	Empathy
Authors: Guadagni Veronica , Burles Ford , Valera Silvana , Hardwicke-Brown Emeleigh , Ferrara Michele , Campbell Tavis , Iaria Giuseppe 
Published: September 2016

Abstract. Sleep loss is known to severely disturb individuals’ mood and emotion processing. Here, we tested the hypothesis that quality of sleep is predictive of individuals’ performance on a task evaluating emotional empathy. We tested 34 healthy undergraduate students [19 males, mean (SD) age = 21.82 (3.26) years; mean (SD) education = 14.98 (1.91) years] recruited through the University of Calgary research participation system. We collected objective (actigraphy) and subjective (questionnaires and self-reports) sleep measures to characterize individuals’ sleep quality, and asked participants to solve a computerized emotional empathy task. We first performed a dimensionality reduction analysis on the sleep-related measures, which resulted in six principal components, and then ran a stepwise multiple regression analysis to investigate the sleep measures that best predicted participants’ scores on the emotional empathy task. We found that subjective sleep quality, together with sleep phase, best predicted participants’ empathic sensitivity to negative images while they explicitly evaluated the emotions of others (i.e., direct component of emotional empathy). Also, subjective sleep quality resulted to be the best predictor of participants’ arousal state in response to negative images, which is an implicit manifestation of their empathic experience (i.e., indirect component of emotional empathy). In both cases, lower subjective sleep quality was associated with lower empathic sensitivity to negative stimuli. Finally, sleep duration best predicted average empathic responses to stimuli of all valences, with shorter sleep durations associated with lower average empathic responses. Our findings provide evidence of a significant relationship between individuals’ quality of sleep and their ability to share the emotions experienced by others. These findings may have important implications for individuals employed in professions requiring social interaction and empathic experience coupled with schedules that interfere with nighttime sleep.
Self-Perceived Competence and Test Anxiety
Authors: Raufelder Diana , Ringeisen Tobias 
Published: September 2016

Abstract. Extrapolating from social-cognitive theory, this research examined whether academic self-efficacy mediates the association between academic self-concept and the four facets of test anxiety (worry, interference, lack of confidence, emotionality) in a large sample of adolescent students (N = 845; Mage = 15.32; SD = 0.49) from Brandenburg, Germany. Quantitative data structural equation modeling (SEM) was employed to analyze these associations. Results showed that there are negative relations between academic self-concept and three facets of test anxiety (namely interference, lack of confidence, emotionality), which are mitigated through academic self-efficacy. All three identified indirect effects revealed full mediation. Overall, the current study extends the literature on test anxiety in education settings by highlighting the importance of academic self-efficacy for prevention and intervention strategies that aim to reduce adolescents’ feelings of test anxiety, as academic self-efficacy fully mediates the association between academic self-concept and three facets of test anxiety, except for worry.
Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling
Authors: Xia Jing , Wang Rong , Zhang Tianlong , Ding Jianping 
Published: September 2016

AbstractThe mechanistic Target Of Rapamycin Complex 1 (mTORC1) is central to the cellular response to changes in nutrient signals such as amino acids. CASTOR1 is shown to be an arginine sensor, which plays an important role in the activation of the mTORC1 pathway. In the deficiency of arginine, CASTOR1 interacts with GATOR2, which together with GATOR1 and Rag GTPases controls the relocalization of mTORC1 to lysosomes. The binding of arginine to CASTOR1 disrupts its association with GATOR2 and hence activates the mTORC1 signaling. Here, we report the crystal structure of CASTOR1 in complex with arginine at 2.5 Å resolution. CASTOR1 comprises of four tandem ACT domains with an architecture resembling the C-terminal allosteric domains of aspartate kinases. ACT1 and ACT3 adopt the typical βαββαβ topology and function in dimerization via the conserved residues from helices α1 of ACT1 and α5 of ACT3; whereas ACT 2 and ACT4, both comprising of two non-sequential regions, assume the unusual ββαββα topology and contribute an arginine-binding pocket at the interface. The bound arginine makes a number of hydrogen-bonding interactions and extensive hydrophobic contacts with the surrounding residues of the binding pocket. The functional roles of the key residues are validated by mutagenesis and biochemical assays. Our structural and functional data together reveal the molecular basis for the arginine-binding specificity of CASTOR1 in the arginine-dependent activation of the mTORC1 signaling.
Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis
Authors: Lee Haeryung , Noh Hyuna , Mun Jiyoung , Gu Changkyu , Sever Sanja , Park Soochul 
Published: September 2016

AbstractErbB2 signalling, which is amplified by EphA2 binding, is an important therapeutic target for breast cancer. Despite the importance of the EphA2/ErbB2 complex in promoting breast tumorigenesis, the mechanism by which these receptor tyrosine kinases (RTKs) are exported from the endoplasmic reticulum (ER) remains poorly understood. Here we report that the PTB adaptor Anks1a is specifically localized to the ER on its own serine phosphorylation. Once there, Anks1a acts as an important regulator of COPII-mediated EphA2 ER export. The Anks1a ankyrin repeat domain binds EphA2 and causes it to accumulate at sites of ER exit. Simultaneously, the Anks1a PTB domain binds Sec23. This induces internalization of EphA2 via COPII vesicles, while Anks1a remains behind on the ER membrane. EphA2 also binds ErbB2 in the ER and seems to load ErbB2 into growing COPII carriers. Together, our study reveals a novel mechanism that regulates the loading of RTKs into COPII vesicles.
Multi-millijoule few-cycle mid-infrared pulses through nonlinear self-compression in bulk
Authors: Shumakova V. , Malevich P. , Ališauskas S. , Voronin A. , Zheltikov A. M. , Faccio D. , Kartashov D. , Baltuška A. , Pugžlys A. 
Published: September 2016

AbstractThe physics of strong-field applications requires driver laser pulses that are both energetic and extremely short. Whereas optical amplifiers, laser and parametric, boost the energy, their gain bandwidth restricts the attainable pulse duration, requiring additional nonlinear spectral broadening to enable few or even single cycle compression and a corresponding peak power increase. Here we demonstrate, in the mid-infrared wavelength range that is important for scaling the ponderomotive energy in strong-field interactions, a simple energy-efficient and scalable soliton-like pulse compression in a mm-long yttrium aluminium garnet crystal with no additional dispersion management. Sub-three-cycle pulses with >0.44 TW peak power are compressed and extracted before the onset of modulation instability and multiple filamentation as a result of a favourable interplay between strong anomalous dispersion and optical nonlinearity around the wavelength of 3.9 μm. As a manifestation of the increased peak power, we show the evidence of mid-infrared pulse filamentation in atmospheric air.
Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33
Authors: Saranchova Iryna , Han Jeffrey , Huang Hui , Fenninger Franz , Choi Kyung Bok , Munro Lonna , Pfeifer Cheryl , Welch Ian , Wyatt Alexander W. , Fazli Ladan , Gleave Martin E. , Jefferies Wilfred A. 
Published: September 2016

AbstractA new paradigm for understanding immune-surveillance and immune escape in cancer is described here. Metastatic carcinomas express reduced levels of IL-33 and diminished levels of antigen processing machinery (APM), compared to syngeneic primary tumours. Complementation of IL-33 expression in metastatic tumours upregulates APM expression and functionality of major histocompatibility complex (MHC)-molecules, resulting in reduced tumour growth rates and a lower frequency of circulating tumour cells. Parallel studies in humans demonstrate that low tumour expression of IL-33 is an immune biomarker associated with recurrent prostate and kidney renal clear cell carcinomas. Thus, IL-33 has a significant role in cancer immune-surveillance against primary tumours, which is lost during the metastatic transition that actuates immune escape in cancer.
Maze learning by a hybrid brain-computer system
Authors: Wu Zhaohui , Zheng Nenggan , Zhang Shaowu , Zheng Xiaoxiang , Gao Liqiang , Su Lijuan 
Published: September 2016

AbstractThe combination of biological and artificial intelligence is particularly driven by two major strands of research: one involves the control of mechanical, usually prosthetic, devices by conscious biological subjects, whereas the other involves the control of animal behaviour by stimulating nervous systems electrically or optically. However, to our knowledge, no study has demonstrated that spatial learning in a computer-based system can affect the learning and decision making behaviour of the biological component, namely a rat, when these two types of intelligence are wired together to form a new intelligent entity. Here, we show how rule operations conducted by computing components contribute to a novel hybrid brain-computer system, i.e., ratbots, exhibit superior learning abilities in a maze learning task, even when their vision and whisker sensation were blocked. We anticipate that our study will encourage other researchers to investigate combinations of various rule operations and other artificial intelligence algorithms with the learning and memory processes of organic brains to develop more powerful cyborg intelligence systems. Our results potentially have profound implications for a variety of applications in intelligent systems and neural rehabilitation.
Sterilization Effects of Adult-targeted Baits Containing Insect Growth Regulators on Delia antiqua
Authors: Zhou Fangyuan , Zhu Guodong , Zhao Haipeng , Wang Zheng , Xue Ming , Li Xianxian , Xu Huaqiang , Ma Xiaodan , Liu Yanyan 
Published: September 2016

AbstractThe onion maggot, Delia antiqua, is a devastating pest of liliaceous crops and current control measures fail to avert pesticide residues, threats to agroecosystem, and costly expenditures. Insect growth regulators (IGRs) are used as trypetid pest chemosterilants for their suppression on adult fertility and fecundity, but their effects on onion flies are unknown. Here, three IGRs (lufenuron, cyromazine, pyriproxyfen) were incorporated into baits to evaluate their effects on onion fly survival, fecundity, fertility, susceptibility of adults in different ages and offspring development. Lufenuron and cyromazine did not affect survival of new-emerged adults, but lufenuron inhibited adult fertility without affecting fecundity, and cyromazine reduced fertility and fecundity. Differently, pyriproxyfen enhanced fecundity within 10 days after treatment, while it reduced adult survival without affecting fertility. The fertility of younger adults was affected by lufenuron and cyromazine whereas the fecundity was affected with cyromazine and pyriproxyfen. For offspring of onion flies treated with lufenuron or cyromazine, most of larvae died within 5 days after hatch, but surviving larvae pupated and emerged normally. Pyriproxyfen did not affect offspring larval survival or pupation but affected pupal emergence. Thus, lufenuron and cyromazine could be potential chemosterilants for onion flies.
Augmented 3D super-resolution of fluorescence-free nanoparticles using enhanced dark-field illumination based on wavelength-modulation and a least-cubic algorithm
Authors: Zhang Peng , Kim Kyungsoo , Lee Seungah , Chakkarapani Suresh Kumar , Fang Ning , Kang Seong Ho 
Published: September 2016

AbstractAugmented three-dimensional (3D) subdiffraction-limited resolution of fluorescence-free single-nanoparticles was achieved with wavelength-dependent enhanced dark-field (EDF) illumination and a least-cubic algorithm. Various plasmonic nanoparticles on a glass slide (i.e., gold nanoparticles, GNPs; silver nanoparticles, SNPs; and gold nanorods, GNRs) were imaged and sliced in the z-direction to a thickness of 10 nm. Single-particle images were then compared with simulation data. The 3D coordinates of individual GNP, SNP, and GNR nanoparticles (x,y,z) were resolved by fitting the data with 3D point spread functions using a least-cubic algorithm and collation. Final, 3D super-resolution microscopy (SRM) images were obtained by resolving 3D coordinates and their Cramér-Rao lower bound-based localization precisions in an image space (530 nm × 530 nm × 300 nm) with a specific voxel size (2.5 nm × 2.5 nm × 5 nm). Compared with the commonly used least-square method, the least-cubic method was more useful for finding the center in asymmetric cases (i.e., nanorods) with high precision and accuracy. This novel 3D fluorescence-free SRM technique was successfully applied to resolve the positions of various nanoparticles on glass and gold nanospots (in vitro) as well as in a living single cell (in vivo) with subdiffraction limited resolution in 3D.
πSPIM: high NA high resolution isotropic light-sheet imaging in cell culture dishes
Authors: Theer Patrick , Dragneva Denitsa , Knop Michael 
Published: September 2016

AbstractLight-sheet fluorescence microscopy (LSFM), also termed single plane illumination microscopy (SPIM), enables live cell fluorescence imaging with optical sectioning capabilities superior to confocal microscopy and without any out-of-focus exposure of the specimen. However, the need of two objective lenses, one for light-sheet illumination and one for imaging, imposes geometrical constraints that require LSFM setups to be adapted to the specific needs of different types of specimen in order to obtain optimal imaging conditions. Here we demonstrate the use of an oblique light-sheet configuration adapted to provide the highest possible Gaussian beam enabled resolution in LSFM. The oblique light-sheet configuration furthermore enables LSFM imaging at the surface of a cover slip, without the need of specific sample mounting. In addition, the system is compatible with simultaneous high NA wide-field epi-fluorescence imaging of the specimen contained in a glass-bottom cell culture dish. This prevents cumbersome sample mounting and enables rapid screening of large areas of the specimen followed by high-resolution LSFM imaging of selected cells. We demonstrate the application of this microscope for in toto imaging of endocytosis in yeast, showing for the first time imaging of all endocytic events of a given cell over a period of >5 minutes with sub-second resolution.
Linkages between atmospheric blocking, sea ice export through Fram Strait and the Atlantic Meridional Overturning Circulation
Authors: Ionita M. , Scholz P. , Lohmann G. , Dima M. , Prange M. 
Published: September 2016

AbstractAs a key persistent component of the atmospheric dynamics, the North Atlantic blocking activity has been linked to extreme climatic phenomena in the European sector. It has also been linked to Atlantic multidecadal ocean variability, but its potential links to rapid oceanic changes have not been investigated. Using a global ocean-sea ice model forced with atmospheric reanalysis data, here it is shown that the 1962–1966 period of enhanced blocking activity over Greenland resulted in anomalous sea ice accumulation in the Arctic and ended with a sea ice flush from the Arctic into the North Atlantic Ocean through Fram Strait. This event induced a significant decrease of Labrador Sea water surface salinity and an abrupt weakening of the Atlantic Meridional Overturning Circulation (AMOC) during the 1970s. These results have implications for the prediction of rapid AMOC changes and indicate that an important part of the atmosphere-ocean dynamics at mid- and high latitudes requires a proper representation of the Fram Strait sea ice transport and of the synoptic scale variability such as atmospheric blocking, which is a challenge for current coupled climate models.