bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategic placement of volunteer responder system defibrillators
Authors: Buter Robin , Nazarian Arthur , Koffijberg Hendrik , Hans Erwin W. , Stieglis Remy , Koster Rudolph W. , Demirtas Derya 
Published: September 2024

AbstractVolunteer responder systems (VRS) alert and guide nearby lay rescuers towards the location of an emergency. An application of such a system is to out-of-hospital cardiac arrests, where early cardiopulmonary resuscitation (CPR) and defibrillation with an automated external defibrillator (AED) are crucial for improving survival rates. However, many AEDs remain underutilized due to poor location choices, while other areas lack adequate AED coverage. In this paper, we present a comprehensive data-driven algorithmic approach to optimize deployment of (additional) public-access AEDs to be used in a VRS. Alongside a binary integer programming (BIP) formulation, we consider two heuristic methods, namely Greedy and Greedy Randomized Adaptive Search Procedure (GRASP), to solve the gradual Maximal Covering Location (MCLP) problem with partial coverage for AED deployment. We develop realistic gradually decreasing coverage functions for volunteers going on foot, by bike, or by car. A spatial probability distribution of cardiac arrest is estimated using kernel density estimation to be used as input for the models and to evaluate the solutions. We apply our approach to 29 real-world instances (municipalities) in the Netherlands. We show that GRASP can obtain near-optimal solutions for large problem instances in significantly less time than the exact method. The results indicate that relocating existing AEDs improves the weighted average coverage from 36% to 49% across all municipalities, with relative improvements ranging from 1% to 175%. For most municipalities, strategically placing 5 to 10 additional AEDs can already provide substantial improvements.
Adalimumab to treat noninfectious pediatric chronic anterior uveitis: a case series
Authors: Ruiz-Lozano Raul E. , Mousa Hazem M. , Soifer Matias , Azar Nadim S. , Quiroga-Garza Manuel E. , Dzhaber Daliya , Murillo Sofia , Song Ailin , Rabinovich C. Egla , Perez Victor L. 
Published: September 2024

Abstract
Purpose
Evaluate the response to adalimumab (ADA) in pediatric chronic anterior uveitis (pCAU).

Methods
Retrospective chart review of pCAU patients treated with ADA. Outcomes evaluated included the proportion of patients achieving zero ocular inflammation and discontinuation of topical corticosteroids, visual outcomes, and incidence of uveitis recurrences after ≥ 12 months of prescribing ADA. Incidence and risk factors for developing anti-adalimumab antibodies (AAAs) were also evaluated.

Results
Of 27 children aged 11 years, 16 (59%) were Caucasian and 6 (22%) African Americans. Thirteen (48%) patients had idiopathic pCAU, 12 (44%) had juvenile idiopathic arthritis (JIA) related pCAU, and 2 (7%) had tubulointerstitial nephritis and uveitis syndrome. At baseline, African American children had worse visual acuity (p = 0.026). At 1 year, 21 (78%) children achieved zero ocular inflammation (remission). Risk factors associated with non-remission were being African American (20% vs. 94%, p = 0.003) and experiencing ≥ 1 episode of uveitis recurrence (100% vs. 0%, p < 0.001). Six episodes of uveitis recurrence were documented in five children, four of whom were African American. Topical corticosteroids were discontinued in 83% of children, and visual acuity remained stable for 1 year. Twelve children were tested for AAAs due to arthritis or uveitis flare-ups, with five (42%) being positive. No significant factors were associated with the development of AAAs.

Conclusions
We found that ADA is effective in controlling inflammation, reducing the need for topical corticosteroids, and maintaining visual acuity in pCAU. There appears to be racial differences in African American children who had worse baseline disease and poorer outcomes. Studies are necessary to understand better and address these disparities.
Impact of Gambling on the Internet on Middle-Term and Long-Term Recovery from Gambling Disorder: A 2-Year Longitudinal Study
Authors: Challet-Bouju Gaëlle , Caillon Julie , Leboucher Juliette , Thiabaud Elsa , Saillard Anaïs , Balem Marianne , Grall-Bronnec Marie 
Published: September 2024

AbstractOnline gamblers are more likely to experience gambling problems. The main objective was to compare the frequency of recovery one (middle-term) and two (long-term) years after treatment initiation, according to the gambling medium (Internet vs. land-based gambling). The secondary objectives were (i) to compare online and offline gamblers at inclusion and (ii) to investigate whether the gambling medium was a predictive factor of recovery. Outpatients beginning treatment for a GD (n = 237) were assessed at inclusion (treatment initiation) and after 1 and 2 years. Bivariate analyses were performed to compare online and offline gamblers at inclusion and on the frequency of recovery at one and two years. Two multivariate logistic regressions were then performed to identify factors associated with middle- and long-term recovery. The majority of patients achieved middle (74.2%) and long-term (78.9%) recovery, with no difference between online and offline gamblers. The gambling medium was not a predictive factor of recovery. Patients with a higher perceived self-efficacy (OR = 1.04 [1.01–1.07], p = .046) and having no history of mood disorders (OR = 11.18 [2.53–49.50], p < .001) at inclusion were more likely to achieve middle-term recovery, while long-term recovery was associated with a lower level of sensation seeking (OR = 0.67 [0.48–0.92], p = .015) at treatment initiation. Online gambling did not seem to influence middle- and long-term recovery compared to offline gambling. Enhancement of perceived self-efficacy and treatment of mood disorders, and treatment strategies focused on sensation-seeking may represent helpful care strategies for favouring achievement of middle-term recovery and maintenance of long-term recovery, respectively. ClinicalTrials.gov NCT01248767, date of first registration: November 25, 2010.
MHD Mixed Convection Flow Over a Permeable Vertical Flat Plate Embedded in a Darcy–Forchheimer Porous Medium
Authors: Merkin John H. , Roșca Natalia C. , Roșca Alin V. , Pop Ioan 
Published: September 2024

AbstractThe purpose of this paper is to describe the stead MHD mixed convection flow over a permeable vertical flat plate embedded in a Darcy–Forchheimer porous medium. Using appropriate similarity variables, the partial differential equations are transformed into ordinary (similar) differential equations, which are numerically solved using the bvp4c function in MATLAB. The numerical results are used to present graphically and in tables, illustrations of the reduced skin friction, reduced Nusselt number, velocity, and temperature profiles. Dual (upper and lower branch) solutions are discovered in this exciting analysis. Although numerous studies on the mixed convection past a vertical plate embedded in a fluid-saturated porous medium exist, none of the researchers have focused on the Darcy–Forchheimer flow with asymptotic solutions. The behavior of the flow and heat transfer has been thoroughly analyzed with the variations in governing parameters, such as Darcy–Forchheimer $$G,$$

G
,

suction/injection $$S$$
S
, MHD $$M,$$

M
,

and mixed convection $$\lambda$$
λ
parameters.
Determination of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index in dogs with leptospirosis
Authors: Durán-Galea A. , Cristóbal-Verdejo J. I. , Macías-García B. , Nicolás-Barceló P. , Barrera-Chacón R. , Ruiz-Tapia P. , Zaragoza-Bayle M. C. , Duque-Carrasco F. J. 
Published: September 2024

AbstractLeptospirosis is a globally distributed zoonosis with multisystemic involvement in canine species, capable of causing a pulmonary hemorrhagic syndrome (LPHS) in the most severe cases. In humans, the neutrophil to lymphocyte ratio (NLR), platelets to lymphocytes (PLR) and systemic immune-inflammation index (SII) have been described as predictors of morbidity and mortality in various pathologies, but no such studies have been developed for canine leptospirosis. Hence, we aimed to assess the usefulness of NLR, PLR and SII in dogs affected with leptospirosis, focusing on those that died or survived after hospitalization, whether or not they developed LPHS. The leptospirosis group was composed by 36 dogs while the control group consisted of 32 healthy dogs. The NLR, associated with inflammation, demonstrated a threefold or greater increase in all leptospirosis groups compared to the control group (median 2.44 ± 1.66) (developing or not LPHS). Dogs that died (median 67.78 ± 158.67), developed LHPS (median 85.17 ± 143.77), or both developed LHPS and died (median 67.78 ± 155,14) had a lower PLR in comparison to the control group (median 101,82 ± 53,75) and the rest of groups, but no statistically significant differences were observed (p > 0.05). The SII was higher in leptospirosis-affected dogs that survived (median 1356,92 ± 2726,29) and statistically significant differences were observed in those who did not develop LPHS (median 1770,41 ± 2630,77; p < 0.05) compared to the control group (median 555,21 ± 313,26). Our data shows that NLR may be used as inflammation indicator, while more studies are needed for PLR and SII in canine leptospirosis.
Exploring the Mechanisms and Therapeutic Approaches of Mitochondrial Dysfunction in Alzheimer’s Disease: An Educational Literature Review
Authors: Moawad Mostafa Hossam El Din , Serag Ibrahim , Alkhawaldeh Ibraheem M. , Abbas Abdallah , Sharaf Abdulrahman , Alsalah Sumaya , Sadeq Mohammed Ahmed , Shalaby Mahmoud Mohamed Mohamed , Hefnawy Mahmoud Tarek , Abouzid Mohamed , Meshref Mostafa 
Published: September 2024

AbstractAlzheimer’s disease (AD) presents a significant challenge to global health. It is characterized by progressive cognitive deterioration and increased rates of morbidity and mortality among older adults. Among the various pathophysiologies of AD, mitochondrial dysfunction, encompassing conditions such as increased reactive oxygen production, dysregulated calcium homeostasis, and impaired mitochondrial dynamics, plays a pivotal role. This review comprehensively investigates the mechanisms of mitochondrial dysfunction in AD, focusing on aspects such as glucose metabolism impairment, mitochondrial bioenergetics, calcium signaling, protein tau and amyloid-beta-associated synapse dysfunction, mitophagy, aging, inflammation, mitochondrial DNA, mitochondria-localized microRNAs, genetics, hormones, and the electron transport chain and Krebs cycle. While lecanemab is the only FDA-approved medication to treat AD, we explore various therapeutic modalities for mitigating mitochondrial dysfunction in AD, including antioxidant drugs, antidiabetic agents, acetylcholinesterase inhibitors (FDA-approved to manage symptoms), nutritional supplements, natural products, phenylpropanoids, vaccines, exercise, and other potential treatments.
Pearls and Pitfalls of Epicardial Echocardiography for Implantation of Impella CP Devices in Ovine Models
Authors: Yastrebov Konstantin , Brunel Laurencie M. , Schnitzler Fiona C. , Partel Lisa M. , Paterson Hugh S. , Bannon Paul G. 
Published: September 2024

AbstractThe Impella CP is a percutaneously inserted temporary left ventricular assist device used in clinical practice and in translational research into cardiogenic shock, perioperative cardiac surgery, acute cardiac failure and mechanical circulatory support. Fluoroscopic guidance is usually used for insertion of an Impella, thus limiting insertion to within catheterization laboratories. Transthoracic, transoesophageal and intracardiac echocardiography have been reported to guide Impella CP implantation with identified specific limitations stemming from the surgical, anatomical and equipment factors. We conducted translational prospective descriptive feasibility investigation as a part of two other hemodynamic Impella studies. It showed the successful application of epicardial echocardiographic scanning for implantation of Impella CP devices in ovine models, from which details of the technique and identified pitfalls are described with practical solutions for future investigators and clinicians. Many described findings are relevant to any other echocardiographic techniques when adequate imaging of the Impella and relevant anatomical structures is achievable.
Graphical Abstract
Indonesian local second-hand clothing: mindful consumption with stimulus-organism-response (SOR) model
Authors: Ilmalhaq Arina , Pradana Mahir , Rubiyanti Nurafni 
Published: September 2024

AbstractThe high demand for the fashion industry currently results in the emergence of the fast fashion phenomenon, prompting consumers to spend more money on unnecessary clothing. This leads to excessive clothing production, which impacts pollution, waste, and emissions. The phenomenon of excessive fashion consumption and production can be mitigated by utilizing second-hand clothing products. Purchasing second-hand clothing products can be classified as part of mindful consumption behavior. The aim of this study is to examine the direct and indirect effects of Electronic Word of Mouth on mindful consumption behavior in the context of local second-hand clothing purchases. Additionally, this study also tests the mediating effects of consumer engagement and environmental attitudes. This research is quantitative in nature, employing data collection through questionnaires from local second-hand clothing consumers within the active workforce demographic (aged 18–59) in Indonesia, yielding 205 respondents. The data analysis technique used is structural equation modeling-partial least square (SEM-PLS). The research findings indicate a significant positive direct influence of Electronic Word of Mouth on environmental attitudes, consumer engagement, and mindful consumption behavior. Moreover, there is a notable positive direct influence between consumer engagement and mindful consumption behavior, while no significant influence is found in the relationship between environmental attitudes and mindful consumption behavior. Furthermore, the study confirms the mediating effect of consumer engagement between Electronic Word of Mouth and mindful consumption behavior but does not support a significant mediating effect of environmental attitudes on local second-hand clothing mindful consumption behavior.
One goodness, many goodnesses, and the Divine Ideas Imitation Theory
Authors: Jeffrey Anne , Ward Thomas M. 
Published: September 2024

Abstract
Some theories of goodness are descriptively rich: they have much to say about what makes things good. Neo-Aristotelian accounts, for instance, detail the various features that make a human being, a dog, a bee good relative to facts about those forms of life. Famously, such theories of relative goodness tend to be comparatively poor: they have little or nothing to say about what makes one kind of being better than another kind. Other theories of goodness – those that take there to be absolute goodness – are comparatively rich: they offer grounds for judging some types of things better than others because they have more absolute goodness. Moorean accounts, for example, can tell us that humans and human experiences are superior to bees and blades of grass. But such theories tend to be descriptively poor: they struggle to tell us in virtue of what this is so. In this article we motivate and flesh out a view that splits the difference between accounts of goodness as relative and accounts of goodness as absolute. Such a view holds promise only if the mechanics of this kind of metaphysics of goodness can be worked out. Here we present a view on which the paradigm for absolute goodness is God and the paradigm for each kind of relative goodness is a divine idea.
The Effect of Nitrogen on the Dihedral Angle Between Fe−Ni Melt and Ringwoodite: Implications for the Nitrogen Deficit in the Bulk Silicate Earth
Authors: Tsuno Kyusei , Grewal Damanveer S. , Xu Virginia , Leinbach Logan , Leinenweber Kurt , Wittmann Axel , Shim Sang‐Heon 
Published: September 2024

AbstractNitrogen (N) is extremely depleted in the bulk silicate Earth (BSE). However, whether the silicate magma ocean was as N‐poor as the present‐day BSE is unknown. We performed multi‐anvil experiments at 20 GPa and 1,673−2,073 K to determine the dihedral angle of Fe−Ni−N alloy melt in ringwoodite matrix to investigate whether percolation of Fe‐rich alloy melt in the solid mantle can explain N depletion in the BSE. The dihedral angles ranged from 112° to 137°, surpassing the wetting boundary. Our experiments suggest that N removal from the mantle by percolation of Fe‐rich alloy melt to the Earth's core is unlikely. Therefore, besides N loss to space during planetesimal and planetary differentiation, as well as its segregation into the Earth core, the stranded Fe‐rich metal in the deep mantle could be a hidden N reservoir, contributing to the anomalous depletion of N in the observable BSE.
Isolation of a NHC-stabilized heavier nitrile and its conversion into an isonitrile analogue
Authors: Doleschal Martin E. , Kostenko Arseni , Liu Jin Yu , Inoue Shigeyoshi 
Published: September 2024

AbstractNitriles (R–C≡N) have been investigated since the late eighteenth century and are ubiquitous encounters in organic and inorganic syntheses. In contrast, heavier nitriles, which contain the heavier analogues of carbon and nitrogen, are sparsely investigated species. Here we report the synthesis and isolation of a phosphino-silylene featuring an N-heterocyclic carbene-phosphinidene and a highly sterically demanding silyl group as substituents. Due to its unique structural motif, it can be regarded as a Lewis base-stabilized heavier nitrile. The Si–P bond displays multiple bond character and a bent R–Si–P geometry, the latter indicating fundamental differences between heavier and classical nitriles. In solution, a quantitative unusual rearrangement to a phosphasilenylidene occurs. This rearrangement is consistent with theoretical predictions of rearrangements from heavier nitriles to heavier isonitriles. Our preliminary reactivity studies revealed that both isomers exhibit highly nucleophilic silicon centres capable of oxidative addition and coordination to iron tetracarbonyl.
Computer vision and statistical insights into cycling near miss dynamics
Authors: Ibrahim Mohamed 
Published: September 2024

AbstractAcross the globe, many transport bodies are advocating for increased cycling due to its health and environmental benefits. Yet, the real and perceived dangers of urban cycling remain obstacles. While serious injuries and fatalities in cycling are infrequent, “near misses”-events where a person on a bike is forced to avoid a potential crash or is unsettled by a close vehicle-are more prevalent. To understand these occurrences, researchers have turned to naturalistic studies, attaching various sensors like video cameras to bikes or cyclists. This sensor data holds the potential to unravel the risks cyclists face. Still, the sheer amount of video data often demands manual processing, limiting the scope of such studies. In this paper, we unveil a cutting-edge computer vision framework tailored for automated near-miss video analysis and for detecting various associated risk factors. Additionally, the framework can understand the statistical significance of various risk factors, providing a comprehensive understanding of the issues faced by cyclists. We shed light on the pronounced effects of factors like glare, vehicle and pedestrian presence, examining their roles in near misses through Granger causality with varied time lags. This framework enables the automated detection of multiple factors and understanding their significant weight, thus enhancing the efficiency and scope of naturalistic cycling studies. As future work, this research opens the possibility of integrating this AI framework into edge sensors through embedded AI, enabling real-time analysis.
Modified Cranial Closing Wedge Osteotomy (AMA-Based CCWO) to Treat Cranial Cruciate Ligament Deficient Stifle in 204 Dogs Over 50 Kg: Magnitude of the Craniocaudal Angulation of the Proximal Tibia and Rate of Surgical Site Infection
Authors: Guénégo Laurent , Vezzoni Aldo , Vezzoni Luca 
Published: September 2024

Abstract
Objectives The aim of this retrospective study was to report the magnitude of the craniocaudal angulation of the proximal tibia (CCAPT) quantified by the angle between the anatomical axis (AA) and the mechanical axis (MA), called the AMA angle, and the tibial plateau angle (TPA) in dogs >50 kg that were treated by cranial closing wedge osteotomy based on the AMA angle (AMA-based CCWO). Furthermore, the percentage of dogs in which the AA and MA could be aligned postoperatively and the rate of surgical site infection (SSI) were reported.
Study Design Medical records (between January 2016 and September 2023) were reviewed for 204 dogs that had AMA-based CCWO stabilized with a double locking plate (DLP) fixation with or without joint exploration plus a Robert Jones bandage (RJB) and were given postoperative antibiotics.
Results The median (range) preoperative AMA angle and TPA were 3.1° (0–5.1°) and 30° (22–49.6°), respectively, and the postoperative AMA angle and TPA were 0° (−2.4 to 1.6°) and 9.2° (4–15°), respectively. The AA and MA were aligned in 82% of dogs. Grade 4 healing occurred in all osteotomies by 8 weeks postoperatively. Except for one dog, no SSIs were recorded.
Conclusion Concerning the magnitude of CCAPT in dogs >50 kg and the low SSI rate, AMA-based CCWO stabilized with a DLP fixation plus an RJB and postoperative antibiotics should be considered for treating cranial cruciate ligament-deficient stifles in this subset of dogs.
Influence of public health emergency on city image: the case of COVID-19 stigma on Wuhan city
Authors: Wang Shanghao , Zheng Xuan 
Published: September 2024

AbstractThis study explored the influence of COVID-19 stigma on the city image of Wuhan by adopting the associative group analysis method. The collected data were free associations of the word “Wuhan” from 39 non-Chinese participants residing outside of China. It found that there were 12 meaning categories related to the city image of Wuhan, half of which were related to COVID-19, and the other half were related to Wuhan city. 56.45% of the associated words were related to COVID-19 and 43.55% to Wuhan city. The results demonstrated that the city image of Wuhan was impacted by the COVID-19 pandemic, mediated by personal experience and perceived media reports. The associated words have constructed a “Wuhan-COVID-19” stereotype, including “Wuhan-birthplace of COVID” and “Wuhan-eating wild animals”. This reflected that the city image of Wuhan endured stigma in the global community. The study provided implications for eliminating stigma and reconstructing group relationships in the global community.
Pseudospin-filter tunneling of massless Dirac fermions
Authors: Li 李 Zhengdong 政栋 , Zeng 曾 Wen 文 
Published: September 2024

Abstract
The tunneling of the massless Dirac fermions through a vector potential barrier are theoretically investigated, where the vector potential can be introduced by very high and very thin (δ-function) magnetic potential barriers. We show that, distinct from the previously studied electric barrier tunneling, the vector potential barriers are more transparent for pseudospin-1/2 Dirac fermions but more obstructive for pseudospin-1 Dirac fermions. By tuning the height of the vector potential barrier, the pseudospin-1/2 Dirac fermions remain transmitted, whereas the transmission of the pseudospin-1 Dirac fermions is forbidden, leading to a pseudospin filtering effect for massless Dirac fermions.