bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micellar Therapy: Acute Treatment with Carvedilol and Curcumin Micelles in SHR for Hypertension Management
Authors: Plantamura Yanina Alejandra Santander , Allo Miguel , Riedel Jennifer , Fuentes Pedro , Riesco Ana Sol , Carranza Andrea , Höcht Christian , Chiappetta Diego , Gorzalczany Susana 
Published: October 2024

Abstract

Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide, requiring innovative therapeutic strategies. This project explores a nano-pharmaceutical approach to enhance the efficacy of cardiovascular drugs, focusing on carvedilol and curcumin. These agents, known for their potential cardiovascular benefits, are encapsulated within Soluplus® micelles to form a novel drug delivery system. The nanomicelles were meticulously characterized for drug loading, size distribution, and morphological features. The release patterns of carvedilol and curcumin were investigated, revealing sustained and controlled release profiles. Additionally, the antioxidant capacity of the micellar formulation was evaluated, demonstrating the preservation of curcumin's antioxidative properties. In vivo studies using spontaneously hypertensive male rats explored the pharmacokinetics and hemodynamic effects of the nanomicellar system. The results indicated successful encapsulation of both drugs without altering their plasma profiles. Furthermore, the administration of carvedilol and curcumin micelles exhibited a more significant reduction in mean arterial pressure compared to individual drug administration, suggesting a potential synergistic effect. In conclusion, this nano-pharmaceutical approach offers a promising avenue for cardiovascular therapy, providing a platform for combined drug delivery and potential synergistic effects. The optimized formulation could lead to improved patient outcomes and enhanced cardiovascular health.
Evaluation of the Clinical Success of Pediatric Fiberglass Crowns in Primary Teeth Using Different Luting Cements: A Randomized Controlled Trial
Authors: Bektaş Kübra , Çiftçi Z.Zahit , Karamete Büşra Buse , Karayılmaz Hüseyin 
Published: October 2024

Abstract

Aims
To evaluate the clinical success, impact on periodontal health, and parental satisfaction of pediatric fiberglass crowns (FGCs) applied to primary molars using two different luting cements.
Methods and Materials
In this study, 60 FGCs were applied to the primary molars of 38 children aged five-nine years, using two different cement materials [glass-ionomer cement (GIC) and resin-modified GIC (RMGIC)]. During the 12-month control period, the retention, anatomical integrity, effect on periodontal health and parental satisfaction of FGCs were evaluated. The plaque index (PI) and gingival index (GI) scores of all teeth, including those treated with crowns (FGC group) and their symmetrical, healthy counterparts (control group), were evaluated both before and after the application of FGCs.
Results
Although the highest survival was observed in the group cemented with RMGIC, there was no significant difference between the groups (p > 0.05). There was no statistically significant change in the periodontal index scores of the FGC group compared with the initial values (p > 0.05). There was a significant decrease in the periodontal index scores of the overall and control groups compared with the initial values (p < 0,05). When the gingival index scores were evaluated, the increase observed in the control sessions compared with the initial values is significantly greater (p ≤ 0.001).
Conclusion
At the end of the 12-month follow-up period, although the survival rate was higher in the RMGIC group, the clinical success rate of FGCs was low in general. It can be suggested that FGCs could serve as an aesthetic alternative for primary tooth crown restorations; however, improvements in their mechanical and surface properties are needed.
Trial Registration
The study was retrospectively registered on www.clinicaltrials.gov with registration number (NCT06558734).
The mediating role of anxiety in poor sleep quality and passive coping among adolescents
Authors: Xin Yongjuan , Zhao Shuxin , Mu Chunguang , Shang Yanna , Yang Wenjie , Hao Changfu 
Published: October 2024

Abstract

Background
The increasing prevalence of poor sleep quality in children and adolescents highlights the essential role of quality sleep in promoting growth and development. Coping styles are associated with cognitive and behavioral adaptations to stress. However, their connection to sleep quality remains unclear.
Methods
In the summer of 2023, a cross-sectional survey was carried out among middle school students in Henan Province, China. The students were randomly chosen from five cities within the province, each representing varying economic levels, using a stratified random sampling approach. The questionnaire comprised inquiries regarding participants’ demographic details, along with assessments of sleep quality, anxiety levels, and coping styles. The Pittsburgh Sleep Quality Index (PSQI) was employed to gauge the sleep quality of middle school students. The Self-Rating Anxiety Scale (SAS) was used to evaluate the anxiety levels of participants. Additionally, coping styles were assessed using the Simplified Coping Style Questionnaire (SCSQ). The correlation coefficients among these three variables were calculated. The significance of the mediation effect was obtained using a bootstrap approach with SPSS PROCESS macro.
Results
This study included 592 middle school students, 76 (12.8%) had a poor sleep quality, while 23.0% showed signs of anxiety. Additionally, 54.6% of students employed passive coping styles in their daily lives. Spearman correlations analysis showed that poor sleep quality was positively correlated with anxiety (r = 0.583, P < 0.01) and passive coping (r = 0.175, P < 0.01). Anxiety was positively correlated with passive coping (r = 0.206, P < 0.01). We validated the significance of the indirect effect of sleep quality mediated through anxiety(95% bootstrap CI = 0.048, 0.112). The percentage of indirect effect was calculated to be 84.4%. The mediating role of anxiety in passive coping and poor sleep quality was established and was fully mediated.
Conclusions
The mediating effect of anxiety on passive coping and poor sleep quality was confirmed and found to be fully mediated. Passive coping style is associated with inadequate sleep quality and the occurrence of anxiety symptoms. Assessing the correlation between sleep quality and coping style among middle school students is crucial for developing effective health promotion strategies to improve students’ health.
Impact of renal impairment on chemotherapy-induced neutropenia in patients who are treated with trifluridine/thymidine phosphorylase inhibitor + bevacizumab for metastatic colorectal cancer
Authors: Shibutani Masatsune , Tanda Hideki , Kasashima Hiroaki , Fukuoka Tatsunari , Kashiwagi Shinichiro , Maeda Kiyoshi 
Published: October 2024

Abstract

Although the phase III SUNLIGHT trial has demonstrated the survival benefit of the addition of bevacizumab (Bmab) to trifluridine/thymidine phosphorylase inhibitor (FTD/TPI), neutropenia, which frequently occurs during FDT/TPI + Bmab therapy, is a concern for clinicians. As TPI is excreted by the kidneys, the risk of adverse events is likely to be high in patients with an impaired renal function. This study aimed to investigate the relationship between renal impairment and the incidence of chemotherapy-induced neutropenia during FTD/TPI + Bmab therapy using real-world data. We retrospectively reviewed the medical records of 69 patients with metastatic colorectal cancer (mCRC) who were treated with FTD/TPI + Bmab for more than 28 days. Patients with renal impairment with an eGFR of 30–44 mL/min/1.73 m2 were defined as the G3b group. Seven patients (10.1%) were classified into the G3b group. Among the 69 patients enrolled in this study, grade ≥ 3 neutropenia was observed in 34 patients (49.3%), and grade 4 neutropenia was observed in 9 patients (13.0%). Patients in the G3b group had an approximately 24% higher incidence of grade ≥ 3 neutropenia in comparison to others (71.4% vs. 46.8%), and the incidence of grade 4 neutropenia in the G3b group was significantly higher than that in others (42.9% vs. 9.7%, p = 0.042). In an analysis limited to the G3b group, of the 5 patients who developed grade ≥ 3 neutropenia, four patients (80%) developed grade ≥ 3 neutropenia, and 2 (40%) developed grade 4 neutropenia within 30 days after initiation of FTD/TPI + Bmab therapy. However, the duration required for neutrophil count to recover to ≥ 1500 /mm3 and the treatment effects of the G3b group were comparable to those observed in other patients. FTD/TPI + Bmab therapy is associated with a high risk of severe neutropenia within 30 days of initiation, especially in patients with a decreased renal function.
Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage
Authors: Gao Dandan , Bin Zou , Zhu Kunyuan , Bi Shijun , Zhang Wenxu , Yang Xinyu , Lai Jieyu , Pan Pengyu , Liang Guobiao 
Published: October 2024

Abstract

Background
Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disorder primarily caused by the rupture of aneurysm, which results in a high mortality rate and consequently imposes a significant burden on society. The occurrence of SAH initiates an immune response that further exacerbates brain damage. The acute inflammatory reaction subsequent to SAH plays a crucial role in determining the prognosis. Th17 cells, a subset of T cells, are related to the brain injury following SAH, and it is unclear how Th17 cells are cleared in the brain. Meningeal lymphatic vessels are a newly discovered intracranial fluid transport system that has been shown to drain large molecules and immune cells to deep cervical lymph nodes. There is limited understanding of the role of the meningeal lymphatic system in SAH. The objective of this research is to explore the impact and underlying mechanism of drainage Th17 cells by meningeal lymphatic on SAH.
Methods
Treatments to manipulate meningeal lymphatic function and CCR7-CCL21 pathway were administered, including laser ablation, injection of VEGF-C, gene knockout and protein injection. Mouse behavior was assessed using the balance beam experiment and the modified Garcia scoring system. Flow cytometry, enzyme-linked immunosorbent assays (ELISA), and immunofluorescence staining were used to study the impact of meningeal lymphatic on SAH drainage. Select patients with unruptured and ruptured aneurysms in our hospital as the control group and the SAH group, with 7 cases in each group. Peripheral blood and cerebrospinal fluid (CSF) samples were assessed by ELISA and flow cytometry.
Results
Mice with SAH showed substantial behavioral abnormalities and brain damage in which immune cells accumulated in brain. Laser ablation of the meningeal lymphatic system or knockout the CCR7 gene leads to Th17 cells aggregation in the meninges, resulting in a decreased neurological function score and increased levels of inflammatory factors. Injection of VEGF-C or CCL21 protein promotes Th17 cells drainage to lymph nodes, an increased neurological function score, and decreased levels of inflammatory factors. Clinical blood and CSF results showed that inflammatory factors in SAH group were significantly increased. The number of Th17 cells in SAH group was significantly higher than control group. Clinical results confirmed Th17 cells aggravated the level of neuroinflammation after SAH.
Conclusion
This study shows that improving the drainage of Th17 cells by meningeal lymphatics via the CCR7-CCL21 pathway can reduce brain damage and improve behavior in SAH mouse model. This could lead to new treatment options for SAH.
Pericallosal Artery Aneurysms: An Evidence-Based Analysis of Clinical Presentations, Therapeutic Approaches, and Outcome
Authors: Badary Amr , Alrefaie Khadeja , Azab Mohammed A. , Almealawy Yasser F. , Alibraheemi Mohammed Q. , Awuah Wireko Andrew , Hernández-Hernández Alan , Alrubaye Sura N. , Ansari Nabiha Midhat , Atallah Oday 
Published: October 2024

Abstract

Background:
Pericallosal artery aneurysms (PCAA) are relatively rare intracranial aneurysms that present unique challenges in diagnosis and management. This study provides a comprehensive review of the literature to assess demographic patterns, risk factors, treatment approaches, and complications associated with PCAA.
Methods:
Data from 23 studies were analyzed using Python with libraries such as Pandas and Matplotlib. Descriptive statistics and crosstabulations explored the relationships between treatment modalities (microsurgical, endovascular, combined) and complications, including hydrocephalus, vasospasms, and intraprocedural ruptures. Visualizations were employed to depict the prevalence and impact of various outcomes.
Results:
Analysis revealed a notable gender disparity, with females constituting 70.47% of the study population. The average age was 49.93 years, and the average aneurysm size was 6.34 mm. A majority of aneurysms were ruptured (542 ruptured vs. 251 unruptured). Risk factors like smoking were prevalent, and radiological features such as subarachnoid hemorrhage (SAH) were commonly reported. Endovascular treatment was slightly more frequent (86.96%) than microsurgical treatment (73.91%). Vasospasm was the most reported complication (56.5%), followed by hydrocephalus and intraprocedural rupture. The mortality rate was 6.82%, with a mean follow-up duration of 20.77 months.
Conclusion:
This review reveals that PCAAs predominantly affect females, with an average patient age of 49.93 years. Aneurysms averaged 6.34 mm and often caused SAH. Endovascular treatments were more common but had higher complication rates than microsurgical methods, which also carried risks. The mortality rate was 6.82%.
Adapted Physical Activity, Exergaming and Relaxation by biofeedback in Hematological intensive care unit – Study protocol of a Randomised Controlled Trial (APAER-H trial)
Authors: BOUSMIA Johanne , LANGLET Cécile , ELNAR Arpiné Ardzivian , GOETZ Christophe , BOLMONT Benoit , DORVAUX Véronique 
Published: October 2024

Abstract

Background:
Hematological malignancies and their treatments are known for their significant adverse effects on health-related quality of life (QoL). During high-dose treatments in Hematological Intensive Care Units (HICU), Adapted Physical Activity (APA) is recognised for its role in maintaining physical fitness and limiting fatigue. Psychological and emotional states are also impaired, with anxiety levels significantly increasing in this specific context. Limited information is available about this topic. However, APA has been shown to reduce anxiety in various population, including oncological patients. Furthermore, adding new technology as exergaming or Heart Rate Variability Biofeedback (HRVB) relaxation tools could be an effective way to regulate emotions during treatments while providing the health-benefits of APA. APA, Exergaming and Relaxation by biofeedback in Hematological intensive care units protocol is a randomised, controlled trial. Our study is designed to evaluate the effects of APA programs during high-dose treatments in HICU on anxiety, fatigue level, functional capacities, immune system activity, and global QoL. Additionally, we aim to analyse the added-value of using specific devices as Exergaming and HRVB relaxation on the aforementioned parameters. We expect a difference in effectiveness between the programs concerning emotional regulation.
Methods:
Ninety patients (18–75 years), with various forms of hematological malignancies admitted to HICU, with haematologist’ approval for APA, will be randomly allocated in a 1:1:1 ratio to three 3-week APA groups: APA only (APA), APA by Exergaming (EXER), APA + HRVB relaxation (BIO). APA sessions will consist of moderate aerobic training on cyclo-ergometer (classical stationary bicycle for APA, BIO and connected ergometer in EXER), 3 times per week. The HRVB training will consist of controlled breathing exercises with biofeedback of heart rate variability at the end of each APA session (BIO).
Discussion:
The primary outcome is to evaluate the effect of 3 short APA programs on state anxiety (HADS; STAI-YA) and fatigue (MFI-20). The secondary outcomes will assess the effects on physical fitness (2MWT; FTSST), QoL (EORTC-QLQC30) and immune system functioning (blood samples). All of these assessments are evaluated initially (T1) and directly after (T2).
Trial Registration:
APAER-H protocol (version 1.1 of the 14/06/2022) was approved by the French Sud Mediteranian III ethical committee and registered on ClinicalTrials.gov: NCT05475600 (https://clinicaltrials.gov/).
MulMed: Addressing Multiple Medical Tasks Utilizing Large Language Models
Authors: Cheng Nannan , Li Fangli , Huang Li 
Published: October 2024

Abstract

The proliferation of large-scale language models, such as ChatGPT, has underscored the urgent requirement to develop Language Models in Medicine (LLMs) to mitigate the burden on healthcare resources. This work introduces MulMed, a model that prioritizes multitasking capabilities in medical domains. MulMed aims to summarize complex medical texts, address patient inquiries, engage in medical question-answering dialogues, demonstrate cross-lingual proficiency, and offer comprehensive medical knowledge coverage. Its key contributions include a two-step fine-tuned modeling framework that enables the model to perform multi-task functions like medical text summarization and Q&A in both English and Chinese, demonstrating excellent generalization abilities on benchmark test sets. The model also exhibits human empathy in doctor-patient consultations, and its fine-tuning process and data are openly available to promote future research in cross-lingual medical models. Additionally, a medical ethics framework is proposed to aid in evaluating the feasibility of medical model applications.
Influence of hemodynamic risk stratification by American Heart Association (AHA) Level of Care (LoC) in Congenital Heart Disease (CHD) on location, mode of delivery and outcome parameters - a single center retrospective observational study
Authors: Hecht Tobias , Bergjan Mara , Bennemann Maike , Steinhard Johannes , Laser Kai Thorsten , Sandica Eugen , Schmitt Manfred , Schubert Stephan 
Published: October 2024

Abstract

Background
The aim of this analysis was to clarify the complexity of CHD in neonates, which are referred to a high-volume pediatric heart center. Does mode or place of delivery within different CHD types influence outcome parameters.
Methods
Observation period for this analysis was 10 years (2011–2021). All neonates younger 28 days with CHD were included and divided into 5 groups according to expected hemodynamic instability using the AHA Level of Care (LoC) Assignment.
Results
Of 1210 neonates, 825 met the inclusion criteria. 397 infants were delivered locally (group A). 428 neonates were transferred from distant hospitals (> 15 km) (group B). The predominant LoC grades were LoC 2 (46%) and LoC 1 (28%). LoC grades 3, 4 and P (palliative care) accounted for 26%. A prenatal diagnosis was available in 54% of cases. The concordance rate with postnatal diagnosis was 88%. 92% of locally delivered infants had a prenatal diagnosis, but only 19% of transferred newborns. There were no differences in mode of delivery, birth weight, and APGAR scores between the different delivery locations. The proportion of univentricular heart defects was 51% in group A at LOC 2 and only 24% in group B. The overall mortality rate was 8.4% at LOC 2, with the highest mortality rate of 12.8% at LOC 4.
Conclusion
25% of our neonates fulfilled the LoC criteria of an increased risk for hemodynamic instability (LoC 3–4). Comparative studies show no differences in perinatal outcomes. Newborns with single ventricle morphology have an increased mortality rate.
The moderating role of workforce participation on the association between inflammatory diet and depression among US adults: findings from NHANES 2005-2018
Authors: Sun Zhenyu , Tang Haoru , Gao Hongliang , Chen Xi , Qian Dongfu 
Published: October 2024

Abstract

Background Depression in the workforce is a highly prevalent and prominent public health problem with pro-inflammatory diet. We aimed to assess the association between inflammatory diet and depression, then to further examine the moderating role of workforce participation on the association of inflammatory diet with depression among US adults aged 20 years or above. Methods Data from the National Health and Nutrition Examination Survey (NHANES) 2005–2018 was used. Binary logistic regression and moderating effect analysis were conducted to explore the associations between inflammatory diet, workforce participation, and depression. Restricted cubic spline (RCS) were employed to evaluate the dose–response association of dietary inflammatory index (DII) and hours worked per week with depression at different levels. Results A total of 23,163 participants were enrolled with a depression prevalence of 7.4%. Both pro-inflammatory diet and not working were risk factors for depression. After adjusting for covariates, adults with pro-inflammatory diet (DII ≥ 0) were more likely to suffer from depression (OR = 1.30; 95%CI: 1.10–1.55). Workforce participation moderated the association between inflammatory diet and depression, especially moderating effect of not working and regular daytime working on the association of DII with depressive tendency was 0.12 and − 0.06. The protective effect of anti-inflammatory diet against depression was only found during the working period of 25 to 45 hours peer week. These effects were consistent across the analyses of subgroup and sensitivity. Conclusions Not working may exacerbate the increase of pro-inflammatory diet to depression risk. Modest regular daytime working (25–45 hours per week) with anti-inflammatory diet may better in reducing depression risk.