bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients
Authors: Panuccio Giuseppe , Correale Pierpaolo , d’Apolito Maria , Mutti Luciano , Giannicola Rocco , Pirtoli Luigi , Giordano Antonio , Labate Demetrio , Macheda Sebastiano , Carabetta Nicole , Abdelwahed Youssef S. , Landmesser Ulf , Tassone Pierfrancesco , Tagliaferri Pierosandro , De Rosa Salvatore , Torella Daniele 
Published: September 2024

Abstract
Immunotherapy represents an emergent and heterogeneous group of anticancer treatments harnessing the human immune-surveillance system, including immune-checkpoint inhibitor monoclonal antibodies (mAbs), Chimeric Antigen Receptor T Cells (CAR-T) therapy, cancer vaccines and lymphocyte activation gene-3 (LAG-3) therapy. While remarkably effective against several malignancies, these therapies, often in combination with other cancer treatments, have showed unforeseen toxicity, including cardiovascular complications. The occurrence of immuno-mediated adverse (irAEs) events has been progressively reported in the last 10 years. These irAEs present an extended range of severity, from self-limiting to life-threatening conditions. Although recent guidelines in CardioOncology have provided important evidence in managing cancer treatments, they often encompass general approaches. However, a specific focus is required due to the particular etiology, unique risk factors, and associated side effects of immunotherapy. This review aims to deepen the understanding of the prevalence and nature of cardiovascular issues in patients undergoing immunotherapy, offering insights into strategies for risk stratification and management.
Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer’s disease continuum
Authors: Denning Amanda E. , Ittyerah Ranjit , Levorse Lisa M. , Sadeghpour Niyousha , Athalye Chinmayee , Chung Eunice , Ravikumar Sadhana , Dong Mengjin , Duong Michael Tran , Li Yue , Ilesanmi Ademola , Sreepada Lasya P. , Sabatini Philip , Lowe MaKayla , Bahena Alejandra , Zablah Jamila , Spencer Barbara E. , Watanabe Ryohei , Kim Boram , Sørensen Maja Højvang , Khandelwal Pulkit , Brown Christopher , Hrybouski Stanislau , Xie Sharon X. , de Flores Robin , Robinson John L. , Schuck Theresa , Ohm Daniel T. , Arezoumandan Sanaz , Porta Sílvia , Detre John A. , Insausti Ricardo , Wisse Laura E. M. , Das Sandhitsu R. , Irwin David J. , Lee Edward B. , Wolk David A. , Yushkevich Paul A. 
Published: September 2024

AbstractThe medial temporal lobe (MTL) is a hotspot for neuropathology, and measurements of MTL atrophy are often used as a biomarker for cognitive decline associated with neurodegenerative disease. Due to the aggregation of multiple proteinopathies in this region, the specific relationship of MTL atrophy to distinct neuropathologies is not well understood. Here, we develop two quantitative algorithms using deep learning to measure phosphorylated tau (p-tau) and TDP-43 (pTDP-43) pathology, which are both known to accumulate in the MTL and are associated with MTL neurodegeneration. We focus on these pathologies in the context of Alzheimer’s disease (AD) and limbic predominant age-related TDP-43 encephalopathy (LATE) and apply our deep learning algorithms to distinct histology sections, on which MTL subregions were digitally annotated. We demonstrate that both quantitative pathology measures show high agreement with expert visual ratings of pathology and discriminate well between pathology stages. In 140 cases with antemortem MR imaging, we compare the association of semi-quantitative and quantitative postmortem measures of these pathologies in the hippocampus with in vivo structural measures of the MTL and its subregions. We find widespread associations of p-tau pathology with MTL subregional structural measures, whereas pTDP-43 pathology had more limited associations with the hippocampus and entorhinal cortex. Quantitative measurements of p-tau pathology resulted in a significantly better model of antemortem structural measures than semi-quantitative ratings and showed strong associations with cortical thickness and volume. By providing a more granular measure of pathology, the quantitative p-tau measures also showed a significant negative association with structure in a severe AD subgroup where semi-quantitative ratings displayed a ceiling effect. Our findings demonstrate the advantages of using quantitative neuropathology to understand the relationship of pathology to structure, particularly for p-tau, and motivate the use of quantitative pathology measurements in future studies.
Corundum-quartz metastability: the role of silicon diffusion in corundum
Authors: Schultze Dina S. , Wirth Richard , Wunder Bernd , Wilke Max , Loges Anselm , Franz Gerhard 
Published: September 2024

AbstractThe synthesis of the Al2SiO5 polymorphs kyanite, sillimanite and andalusite in a pure Al2O3–SiO2–H2O (ASH) system has long been known to be impeded. In order to decipher individual aspects of the reaction: corundum + SiO2aq, which repeatedly fails to produce thermodynamically stable Al2SiO5, we conducted experiments within the stability fields of kyanite and sillimanite (500–800 ℃; 0.2–1 GPa) with the aim of forming reaction coronas on corundum. Results showed that metastable corundum + quartz assemblages form persistently in pure ASH, even in Al2SiO5 seeded experiments, despite the presence of catalyzing fluid and evidence of fast reaction kinetics. Coronas on corundum spontaneously formed when additional components (Na, K, N, and Mg) were added to the experiment. In a similar experiment with baddeleyite (ZrO2) instead of corundum in silica saturated water, a zircon corona formed readily. This implies that nucleation and growth of Al2SiO5 is obstructed under conditions of Al and Si saturation in aqueous fluid, while both corundum and quartz saturated aqueous fluid are willing participants in other reactions towards stable corona formation. Instead of Al2SiO5 precipitation, an unexpected fluid-aided silica diffusion process into corundum was documented. The latter included the formation of nanometer wide hydrous silicate layers along the basal plane of the corundum host, which enhanced the silica diffusion rate drastically, leading to silica supersaturation in the host mineral, and ultimately to precipitation of quartz inside corundum. We conclude that the natural metastable assemblage of quartz and corundum is not necessarily the result of dry or fluid absent conditions, given that the aqueous fluid in experiments does not promote Al2SiO5 formation, but rather seems to support the formation and preservation of a metastable assemblage.
Immune checkpoint inhibitors-associated cranial nerves involvement: a systematic literature review on 136 patients
Authors: Pichon Samuel , Aigrain Pauline , Lacombe Charlotte , Lemarchant Bruno , Ledoult Emmanuel , Koether Vincent , Leurs Amélie , Zebian Ghadi , Launay David , Gachet Benoit , Levy Clémentine 
Published: September 2024

Abstract
Objective
Describe the demographic data and clinical phenotype of cranial palsy induced by immune checkpoint inhibitors (CNP-ICI).

Methods
A systematic literature review of the literature was performed in Pubmed, Web of Science, and Embase, including 68 articles and 136 patients (PROSPERO no. CRD42024517262).

Results
Out of the 1205 articles screened, 68 articles were included after fulfilling the inclusion criteria, for a total of 136 patients. All articles were case reports and case series. In the cohort studied, 52% of patients were treated with anti PD-1/PDL-1 therapies, 14% with anti CTLA-4 therapies, and 34% with a combination of anti CTLA-4 and anti PD-1/PDL-1 therapies. The facial nerve was the most affected cranial nerve, involved in 38% of cases, followed by the optic nerve (35%), the cochleovestibular nerve (12%), and the abducens nerve (10%). The median time from the initial immune checkpoint inhibitor (ICI) injection to the onset CNP-ICI was 10 weeks (IQR 4–20). Magnetic resonance imaging demonstrated contrast enhancement or abnormal signal of the affected nerve in 43% of cases. Cerebrospinal fluid analysis indicated lymphocytic pleocytosis in 59% of cases. At the onset of immune-related adverse events, 89% of patients discontinued immunotherapy, and 92% received treatment for CNP-ICI. Treatment regimens included corticosteroids in 86% of cases, intravenous immunoglobulin in 21%, and plasma exchange in 5.1%. Among the whole population, 33% achieved recovery, 52% showed clinical improvement, 16% remained stable, and 3% experienced worsening of their condition. Rechallenge with immunotherapy was significantly associated with the emergence of new immune-related Adverse Events (irAEs).

Conclusion
ICI therapy may lead to cranial nerve involvement, particularly affecting the facial nerve, typically presenting around 10 weeks after treatment initiation. While corticosteroid therapy often resulted in patient improvement, rechallenging with ICIs were associated with new irAEs.
Registration accuracy comparing different rendering techniques on local vs external virtual 3D liver model reconstruction for vascular landmark setting by intraoperative ultrasound in augmented reality navigated liver resection
Authors: Sheriff Nonkoh J. , Thomas Michael , Bunck Alexander C. , Peterhans Matthias , Datta Rabi Raj , Hellmich Martin , Bruns Christiane J. , Stippel Dirk Ludger , Wahba Roger 
Published: September 2024

Abstract
Purpose
Augmented reality navigation in liver surgery still faces technical challenges like insufficient registration accuracy. This study compared registration accuracy between local and external virtual 3D liver models (vir3DLivers) generated with different rendering techniques and the use of the left vs right main portal vein branch (LPV vs RPV) for landmark setting. The study should further examine how registration accuracy behaves with increasing distance from the ROI.

Methods
Retrospective registration accuracy analysis of an optical intraoperative 3D navigation system, used in 13 liver tumor patients undergoing liver resection/thermal ablation.

Results
109 measurements in 13 patients were performed. Registration accuracy with local and external vir3DLivers was comparable (8.76 ± 0.9 mm vs 7.85 ± 0.9 mm; 95% CI = -0.73 to 2.55 mm; p = 0.272). Registrations via the LPV demonstrated significantly higher accuracy than via the RPV (6.2 ± 0.85 mm vs 10.41 ± 0.99 mm, 95% CI = 2.39 to 6.03 mm, p < 0.001). There was a statistically significant positive but weak correlation between the accuracy (dFeature) and the distance from the ROI (dROI) (r = 0.298; p = 0.002).

Conclusion
Despite basing on different rendering techniques both local and external vir3DLivers have comparable registration accuracy, while LPV-based registrations significantly outperform RPV-based ones in accuracy. Higher accuracy can be assumed within distances of up to a few centimeters around the ROI.
Levels of plasma 25-hydroxy vitamin D and risk of developing type 2 diabetes in a large Danish primary health care population
Authors: Rohold Cecilie Korneliusen , Jørgensen Henrik Løvendahl , Vojdeman Fie Juhl , Madsen Christian Medom , Olsen Anja , Heegaard Anne-Marie , Lind Bent Struer , Tjønneland Anne , Schwarz Peter , Gæde Peter Haulund 
Published: September 2024

Abstract
Aims
Plasma levels of Vitamin D (25(OH)D) have been suggested as a predictor for developing type 2 diabetes. The purpose of this study was therefore to investigate if a measurement of plasma 25(OH)D could predict the development of type 2 diabetes in a cohort of 222,311 individuals from primary healthcare in Denmark.

Methods
The CopD-study database containing data from the Copenhagen General Practitioners Laboratory on blood tests conducted from April 2004 to January 2012 was used for identification of the study population. Incident type 2 diabetes was then defined as having at least two redeemed prescriptions of antidiabetics or at least two hospital contacts due to type 2 diabetes or one redeemed prescription and one hospital contact regarding type 2 diabetes.

Results
A total of 222,311 individuals were included in the study, of whom 7652 (3.4%) developed type 2 diabetes during the follow-up period of minimum one year. Individuals who developed type 2 diabetes had a significantly lower median 25(OH)D level than persons in the non-diabetes group. The hazard ratio for development of type 2 diabetes increased by 15% per 10 n mol/L decrease in 25(OH)D level.

Conclusion
In this study of 222,311 persons from primary health care in Denmark, we found a clear inverse relationship between 25(OH)D and the risk of developing type 2 diabetes.
Further studies should be conducted to clarify the mechanisms behind the relationship between 25(OH)D and type 2 diabetes and the effect of oral vitamin D supplementation on the development of type 2 diabetes.
Improving the Annotation Process in Computational Pathology: A Pilot Study with Manual and Semi-automated Approaches on Consumer and Medical Grade Devices
Authors: Cazzaniga Giorgio , Del Carro Fabio , Eccher Albino , Becker Jan Ulrich , Gambaro Giovanni , Rossi Mattia , Pieruzzi Federico , Fraggetta Filippo , Pagni Fabio , L’Imperio Vincenzo 
Published: September 2024

AbstractThe development of reliable artificial intelligence (AI) algorithms in pathology often depends on ground truth provided by annotation of whole slide images (WSI), a time-consuming and operator-dependent process. A comparative analysis of different annotation approaches is performed to streamline this process. Two pathologists annotated renal tissue using semi-automated (Segment Anything Model, SAM)) and manual devices (touchpad vs mouse). A comparison was conducted in terms of working time, reproducibility (overlap fraction), and precision (0 to 10 accuracy rated by two expert nephropathologists) among different methods and operators. The impact of different displays on mouse performance was evaluated. Annotations focused on three tissue compartments: tubules (57 annotations), glomeruli (53 annotations), and arteries (58 annotations). The semi-automatic approach was the fastest and had the least inter-observer variability, averaging 13.6 ± 0.2 min with a difference (Δ) of 2%, followed by the mouse (29.9 ± 10.2, Δ = 24%), and the touchpad (47.5 ± 19.6 min, Δ = 45%). The highest reproducibility in tubules and glomeruli was achieved with SAM (overlap values of 1 and 0.99 compared to 0.97 for the mouse and 0.94 and 0.93 for the touchpad), though SAM had lower reproducibility in arteries (overlap value of 0.89 compared to 0.94 for both the mouse and touchpad). No precision differences were observed between operators (p = 0.59). Using non-medical monitors increased annotation times by 6.1%. The future employment of semi-automated and AI-assisted approaches can significantly speed up the annotation process, improving the ground truth for AI tool development.
Aetiological Naturalism in the Philosophy of Medicine: A Shaky Project
Authors: Davini Claudio 
Published: September 2024

AbstractGriffiths and Matthewson (2018) employ the selected effects theory to contend that disease involves the impairment of the normal functioning of biological items. Since the selected effects theory focuses on the past effects of those items, I refer to their proposal as “aetiological naturalism”. In this paper, I argue that aetiological naturalism cannot constitute an adequate theory of disease. This is due to the fact that the selected effects theory, which lies at the heart of aetiological naturalism, is flawed. One promise of the selected effects theory is indeed that it is able to account for our normative intuitions about dysfunctional biological items by grounding them on the concept of natural selection incorporated in the selected effects theory itself, where this promise rests upon its claim that appealing to the fitness-enhancing effect of biological items can always explain why they persisted in a population. However, I contend that the naturalisation of normativity cannot be cashed out in terms of biological items’ past effects by discussing two biological phenomena: phenotypic plasticity and negative frequency-dependent selection. I illustrate that in both cases the selected effects theory cannot recognise adaptive items as having a selected effects function, therefore preventing the possibility to assign them any dysfunction. The normative force of the selected effects theory is consequently much diminished, leading in turn to a weakening of aetiological naturalism, given that such project actually relies on the assumed normative force of the selected effects theory itself.
The Promise and Challenges of Integrating Biological and Prevention Sciences: A Community-Engaged Model for the Next Generation of Translational Research
Authors: Leve Leslie D. , Kanamori Mariano , Humphreys Kathryn L. , Jaffee Sara R. , Nusslock Robin , Oro Veronica , Hyde Luke W. 
Published: September 2024

AbstractBeginning with the successful sequencing of the human genome two decades ago, the possibility of developing personalized health interventions based on one’s biology has captured the imagination of researchers, medical providers, and individuals seeking health care services. However, the application of a personalized medicine approach to emotional and behavioral health has lagged behind the development of personalized approaches for physical health conditions. There is potential value in developing improved methods for integrating biological science with prevention science to identify risk and protective mechanisms that have biological underpinnings, and then applying that knowledge to inform prevention and intervention services for emotional and behavioral health. This report represents the work of a task force appointed by the Board of the Society for Prevention Research to explore challenges and recommendations for the integration of biological and prevention sciences. We present the state of the science and barriers to progress in integrating the two approaches, followed by recommended strategies that would promote the responsible integration of biological and prevention sciences. Recommendations are grounded in Community-Based Participatory Research approaches, with the goal of centering equity in future research aimed at integrating the two disciplines to ultimately improve the well-being of those who have disproportionately experienced or are at risk for experiencing emotional and behavioral problems.
Economic Disparities, Life Events, and the Gender Mental Health Gap
Authors: Nguyen Thi Thao , Nguyen Kim Huong , Rohde Nicholas 
Published: September 2024

AbstractThis paper studies factors explaining the gender mental health gap using Australian data. We show that men have significantly higher mean outcomes and the left tail of the combined distribution is disproportionately female. Using regression-based decompositions, we examine the degree that both socioeconomic inequalities and life experience account for this phenomenon. We find that disparities in income play a substantial role, and subject to an assumption of exogeneity, would be enough to account for the gender gap amongst individuals with very poor psychological wellbeing. We also examine the mental health effects of various negative life experience, such as the death of a family member or being a victim of violence. At the individual level, these variables have large effect sizes but are not strongly correlated with gender to explain our mental health disparities.
A scoping review on adult patients with de novo glomerular diseases following COVID-19 infection or vaccine
Authors: Qi Liam , Deep Aman , Fox Jordan , Yii Mark , Rahman Muhammad , Myint Mar , Myat Htoo , Thet Zaw 
Published: September 2024

Abstract

Background
There are increasing reports of glomerular disease (GD) following COVID-19 infection and vaccination. Current evidence on the possible link between COVID-19 infection or vaccination and GD is conflicting.

Objective
The present study undertakes a scoping review of research to describe the relationship between COVID-19 infection and vaccination with GD and the common management strategies and overall outcomes of the disease to identify knowledge gaps and guide further research.

Eligibility criteria
All original research studies published in English until 5th September 2022 were considered for inclusion in the review. Exclusion criteria were animal studies, autopsy studies, and data involving patients who were paediatric patients (< 16 years), were transplant recipients, had a recurrence of glomerular disease, had concomitant cancer or non-COVID-19 infection which may cause glomerular disease, or did not receive a renal biopsy.

Sources of evidence
The five electronic databases searched were MEDLINE, PubMed, Scopus, EMBASE, and Cochrane.

Methods
Two separate search strings related to COVID-19, and glomerular disease were combined using the Boolean operator ‘AND’. Filters were used to limit publications to original research studies published in English. Search results from each database were imported into Covidence software (www.covidence.org) and used for de-duplication, article screening, and data extraction. Descriptive analyses were used to summarise demographics, diagnoses, and treatment outcomes.

Results
After removing duplicates, 6853 titles and abstracts were screened. Of the 188 studies included, 106 studies described 341 patients with GD following COVID-19 infection and 82 described 146 patients with GD following a COVID-19 vaccination. IgA nephropathy was the most common GD pathology reported following COVID-19 vaccination with GD most common following mRNA vaccines. Collapsing focal segmental glomerulosclerosis was the most common GD following COVID-19 infection. Immunosuppressive treatment of GD was more common in the vaccine cohort than in the infection cohort.

Conclusion
Despite the significant number of COVID-19 infections and vaccinations around the world, our understanding of GD associated with COVID-19 infection and vaccination remains poor, and more research is needed to understand the possible relationship better.