bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review of adherence rates by medication class in type 2 diabetes: a study protocol
Authors: McGovern Andrew , Tippu Zayd , Hinton William , Munro Neil , Whyte Martin , de Lusignan Simon 
Published: March 2016

IntroductionTreatment options for type 2 diabetes are becoming increasingly complex with people often prescribed multiple medications, and may include both oral and injectable therapies. There is ongoing debate about which drug classes provide the optimum second-line and third-line treatment options. In the real world, patient adherence and persistence determines medication effectiveness. A better understanding of adherence may help inform the choice of second-line and third-line drug classes.Methods and analysisThis systematic review will compare adherence and persistence rates across the different classes of medication available to people with type 2 diabetes. It will include all identified studies comparing medication adherence or persistence between two or more glucose-lowering medications in people with type 2 diabetes. Research databases (MEDLINE, EMBASE, The Cochrane Library, The Register of Controlled Trials, PsychINFO and CINAHL) will be searched for relevant articles, using a comprehensive search strategy. All identified medication trials and observational studies will be included which compare adherence or persistence across classes of diabetes medication. The characteristics and outcomes of all the included studies will be reported along with a study quality grade, assessed using the Cochrane Risk Assessment Tool. The quality of adjustment for confounders of adherence or persistence will be reported for each study. Where multiple (n ≥3) studies provide compare adherence or persistence across the same 2 medication classes, a meta-analysis will be performed.Ethics and disseminationNo ethics approval is required. This review and meta-analysis (where possible) will provide important information on the relative patient adherence and persistence, with the different classes of diabetes therapies. Once complete, the results will be made available by peer-reviewed publication.Trial registration numberCRD42015027865.
Perceptions of music therapy for older people among healthcare professionals
Authors: Khan Waqas Ullah , Mohamad Onn Yap Irin Arina , O'Neill Desmond , Moss Hilary 
Published: March 2016

Purpose of studyTo investigate the perceptions of healthcare providers on music therapy and their recommendations on wider adoption in a hospital setting.Design and methodsA qualitative exploratory study employing short semistructured interviews using a thematic analysis method of data analysis.InterventionA qualitative exploratory study, employing short semistructured interviews was conducted in March 2015 in an urban teaching hospital to explore healthcare providers’ attitudes towards and recommendations on music therapy. Convenience sampling was used for recruitment of hospital staff from a multidisciplinary geriatric unit. Only staff who had exposure, awareness, or participated in the hospital music therapy programme were asked to partake in an in-depth qualitative interview.Main findingsThemes emerging reflected a belief among hospital staff that music therapy was of benefit to patients and staff; perceptions of how a hospital music therapy programme should be implemented and a desire for expansion of the music therapy programme throughout the hospital setting.Principal conclusionsMusic therapy is of great importance to patients and healthcare professionals, and thus more attention is warranted to better integrate and advance this programme. This study is important because although numerous studies have examined music therapy from a patient health perspective, no report has analysed the perceptions of healthcare providers on this intervention and their recommendations on further development of music therapy services.
Effect of minor Fe substitution for Ni on the magnetic properties of a Gd55Al20Ni25 bulk metallic glass
Authors: Ding Ding , Li Zheng , Wang Zheng Wen , Wu Cheng , Zhang Yi Qing 
Published: March 2016

In this work, we studied the effect of micro-alloying on the glass-forming ability (GFA) and magnetic properties of [Formula: see text] bulk metallic glass (BMG). By minor Fe substitution for Ni, we obtained [Formula: see text] BMG with enhanced magneto-caloric effect (MCE) and GFA similar to [Formula: see text] BMG. The maximum magnetic entropy change [Formula: see text] and the magnetic refrigerant capacity ([Formula: see text] of [Formula: see text] BMG within the field range of 5 T are about 9.05 J kg[Formula: see text] K[Formula: see text] and [Formula: see text], respectively, both of which are larger than the values of [Formula: see text] BMG. The mechanism for the improved MCE of the [Formula: see text] BMG was investigated and the magneto-caloric behaviors were studied by constructing the field dependence of [Formula: see text] of [Formula: see text] BMG.
Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells
Authors: Lucenay Kimberly S. , Doostan Iman , Karakas Cansu , Bui Tuyen , Ding Zhiyong , Mills Gordon B. , Hunt Kelly K. , Keyomarsi Khandan 
Published: March 2016

AbstractCyclin E is altered in nearly a third of invasive breast cancers where it is a powerful independent predictor of survival in women with stage I–III disease. Full-length cyclin E is posttranslationally cleaved into low molecular weight (LMW-E) isoforms, which are tumor-specific and accumulate in the cytoplasm because they lack a nuclear localization sequence. We hypothesized that aberrant localization of cytosolic LMW-E isoforms alters target binding and activation ultimately contributing to LMW-E–induced tumorigenicity. To address this hypothesis, we used a retrovirus-based protein complementation assay to find LMW-E binding proteins in breast cancer, identifying ATP-citrate lyase (ACLY), an enzyme in the de novo lipogenesis pathway, as a novel LMW-E–interacting protein in the cytoplasm. LMW-E upregulated ACLY enzymatic activity, subsequently increasing lipid droplet formation, thereby providing cells with essential building blocks to support growth. ACLY was also required for LMW-E–mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo. In clinical specimens of breast cancer, the absence of LMW-E and low expression of adipophilin (PLIN2), a marker of lipid droplet formation, associated with favorable prognosis, whereas overexpression of both proteins correlated with a markedly worse prognosis. Taken together, our findings establish a novel relationship between LMW-E isoforms of cyclin E and aberrant lipid metabolism pathways in breast cancer tumorigenesis, warranting further investigation in additional malignancies exhibiting their expression. Cancer Res; 76(8); 2406–18. ©2016 AACR.
New Strategies in Myeloproliferative Neoplasms: The Evolving Genetic and Therapeutic Landscape
Authors: Patel Ami B. , Vellore Nadeem A. , Deininger Michael W. 
Published: March 2016

Abstract
The classical BCR–ABL1-negative myeloproliferative neoplasms (MPN) include essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF). Although these clonal disorders share certain clinical and genetic features, MF in particular is distinct for its complex mutational landscape, severe disease phenotype, and poor prognosis. The genetic complexity inherent to MF has made this disease extremely challenging to treat. Pharmacologic JAK inhibition has proven to be a transformative therapy in MPNs, alleviating symptom burden and improving survival, but has been hampered by off-target toxicities and, as monotherapy, has shown limited effects on mutant allele burden. In this review, we discuss the genetic heterogeneity contributing to the pathogenesis of MPNs, focusing on novel driver and epigenetic mutations and how they relate to combination therapeutic strategies. We discuss results from ongoing studies of new JAK inhibitors and report on new drugs and drug combinations that have demonstrated success in early preclinical and clinical trials, including type II JAK inhibitors, antifibrotic agents, and telomerase inhibitors. Clin Cancer Res; 22(5); 1037–47. ©2016 AACR.
PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma
Authors: Field Matthew G. , Decatur Christina L. , Kurtenbach Stefan , Gezgin Gülçin , van der Velden Pieter A. , Jager Martine J. , Kozak Kaleigh N. , Harbour J. William 
Published: March 2016

Abstract
Purpose: Uveal melanoma (UM) can be classified by gene expression profiling (GEP) into Class 1 (low metastatic risk) and Class 2 (high metastatic risk), the latter being strongly associated with mutational inactivation of the tumor suppressor BAP1. Nevertheless, a small percentage of Class 1 tumors give rise to metastatic disease. The purpose of this study was to identify biomarkers of metastasis in Class 1 tumors.
Experimental Design: A total of 389 consecutive patients with UM were assigned to Class 1 or Class 2 using a prospectively validated 12-gene prognostic classifier. Selected tumors were further analyzed using global GEP and single nucleotide polymorphism microarrays. PRAME (preferentially expressed antigen in melanoma) mRNA expression was analyzed in 64 Class 1 tumors by qPCR.
Results: Among Class 1 UMs, the most significant predictor of metastasis was PRAME mRNA expression (P = 0.0006). The 5-year actuarial rate of metastasis was 0% for Class1PRAME−, 38% for Class1PRAME+, and 71% for Class 2 tumors. Median metastasis-free survival for Class1PRAME+ patients was 88 months, compared to 32 months for Class 2 patients. Findings were validated using three independent datasets, including one using disomy 3 to identify low-risk UM. Chromosome copy number changes associated with Class1PRAME+ tumors included gain of 1q, 6p, 8q, and 9q and loss of 6q and 11q. PRAME expression was associated with larger tumor diameter (P = 0.05) and SF3B1 mutations (P = 0.003).
Conclusions: PRAME is an independent prognostic biomarker in UM, which identifies increased metastatic risk in patients with Class 1 or disomy 3 tumors. This finding may further enhance the accuracy of prognostic testing and precision medicine for UM. Clin Cancer Res; 22(5); 1234–42. ©2016 AACR.
Autoimmune Bullous Skin Disorders with Immune Checkpoint Inhibitors Targeting PD-1 and PD-L1
Authors: Naidoo Jarushka , Schindler Katja , Querfeld Christiane , Busam Klaus , Cunningham Jane , Page David B. , Postow Michael A. , Weinstein Alyona , Lucas Anna Skripnik , Ciccolini Kathryn T. , Quigley Elizabeth A. , Lesokhin Alexander M. , Paik Paul K. , Chaft Jamie E. , Segal Neil H. , D'Angelo Sandra P. , Dickson Mark A. , Wolchok Jedd D. , Lacouture Mario E. 
Published: March 2016

Abstract
Monoclonal antibodies (mAb) targeting immune checkpoint pathways such as cytotoxic T-lymphocyte–associated protein 4 (CTLA-4) and programmed death 1 (PD-1) may confer durable disease control in several malignancies. In some patients, immune checkpoint mAbs cause cutaneous immune-related adverse events. Although the most commonly reported cutaneous toxicities are mild, a subset may persist despite therapy and can lead to severe or life-threatening toxicity. Autoimmune blistering disorders are not commonly associated with immune checkpoint mAb therapy. We report a case series of patients who developed bullous pemphigoid (BP), an autoimmune process classically attributed to pathologic autoantibody formation and complement deposition. Three patients were identified. Two patients developed BP while receiving the anti–PD-1 mAb nivolumab, and one while receiving the anti–PD-L1 mAb durvalumab. The clinicopathologic features of each patient and rash, and corresponding radiologic findings at the development of the rash and after its treatment, are described. Patients receiving an anti–PD-1/PD-L1 mAb may develop immune-related BP. This may be related to both T-cell– and B-cell–mediated responses. Referral to a dermatologist for accurate diagnosis and management is recommended. Cancer Immunol Res; 4(5); 383–9. ©2016 AACR.
Вплив блокування м1-холінорецепторів асоціативної кори дорослих щурів на автономну регуляцію серцевого ритму при гіпоксичному впливі
Authors: Volkova N. M. 
Published: March 2016

<p>Резюме. Моделювання атмосферної гіпоксії в експерименті на щурах дозволяє більш детально дослідити участь речовин медіаторної дії у формуванні адаптації регуляторних систем мозку до гіпоксичного впливу. Метою експерименту було виявити функціональні наслідки блокування м<sub>1</sub>-холінорецепторів в асоціативній корі дорослих щурів у гіпоксичному середовищі за умов зниженого атмосферного тиску. За умов експериментальної гіпоксії спостерігали функціональну перебудову включення холінергічних структур до механізмів автономного контролю серцевого ритму. Інкубація дорослих щурів у гіпоксичному середовищі за умов зниженого атмосферного тиску, аналогічному природним умовам ІІІ типу погоди, призводить до активації холінергічної регуляції серцевого ритму.</p><p> </p><p>Ключові слова: блокування м<sub>1</sub>-холінорецепторів, асоціативна кора, знижений атмосферний тиск.</p>
ПОРУШЕННЯ ІМУННОГО ГОМЕОСТАЗУ В РАННІЙ ПЕРІОД РОЗВИТКУ ЕКСПЕРИМЕНТАЛЬНОЇ ПНЕВМОНІЇ
Authors: Reheda S. M. , Furdychko L. O. , Reheda-Furdychko M. M. 
Published: March 2016

<p>Резюме. В експерименті на морських свинках показано, що пневмонія супроводжується порушеннями показників імунної системи, які проявлялися поступовим зростанням вмісту В-лімфоцитів і циркулюючих імунних комплексів (ЦІК) на 4-у і 8-у доби на тлі зниження рівня Т-лімфоцитів у крові на 8-у добу розвитку запального процесу в легенях.</p><p> </p>КЛЮЧОВІ СЛОВА: експериментальна пневмонія, циркулюючі імунні комплекси, Т і В-лімфоцити.
Переваги малотравматичної аутодермопластики з використанням трансплантатів ультратонкого зрізу у хворих з опіками
Authors: Kovalchuk A. О. , OLIYNYK N. YU. 
Published: March 2016

<p>У статті проведено дослідження ефективності пластичного закриття опікових ран тонкими та ультратонкими аутодермотрансплантатами. На прикладі 2 груп хворих доведено переваги малотравматичної аутодермопластики над класичним методом пластики ран. Доведено, що застосування розщеплених шкірних трансплантатів ультратонкого зрізу при проведенні аутодермопластики в обпечених хворих значно скорочує тривалість регенерації донорських ран, знижує об’єм післяопераційної крововтрати, покращує загальний стан пацієнтів та скорочує середній ліжко-день перебування пацієнтів у стаціонарі.</p>
Effects of selenium-zinc-lipid substances from Chlorella vulgaris Biej. on oxidative and tnergy status of rats
Authors: Vinyarska H. B. , Lykhatskyi P. H. , Bodnar O. I. , Fira L. S. , Grubinko V. V. 
Published: March 2016

<p>There were obtained and allocated stable selen-lipid and selen-zinc-lipid substances in a result of incubationof unicellular algae Chlorella vulgaris Biej. In aquaculture with sodium selenite and zinc sulfate their influence on oxidative and energetic status of healthy rat was investigated. There were suppressed prooxidative processes,activated antioxidant status, succinate dehydrogenase and cytochrome oxidase activity and glutamate dehydrogenase way of formation of glutamate were increased when substance at a dose of 0.4 mcg of selenium, 2.5 mcg of zinc<br />and 0.5 mg of lipid per 1 ml of 1 % starch-water suspensions was introduced in organisme of healthy rats. Also it contributed of formation and functioning of the active components of the antioxidant system – catalase, ceruloplasmin,<br />reduction glutathione in a liver and in a blood serum of experimental animals.</p>
A new small golden frog of the genus Pristimantis (Anura: Craugastoridae) from an Andean cloud forest of Colombia
Authors: Rivera-Correa Mauricio , Lamadrid-Feris Faride , Crawford Andrew J. 
Published: March 2016

A new species ofPristimantisis described from an Andean cloud forest at 2650 m in the Cordillera Oriental of Colombia.Pristimantis doradosp. nov. is similar to and could be closely related toP. acutirostris, but can be readily distinguished from this latter species by the absence of a tympanic annulus, vocal slits, vocal sac and reticulations on concealed surfaces, and by having a metallic gold iris with a brown horizontal streak. The phylogenetic position of the new species is recovered and we provide its advertisement call, which this species manages to emit despite lacking a vocal sac and vocal slits. This discovery reminds us that despite the extensive research on the alpha-taxonomy ofPristimantisin Colombia, fieldwork in high montane forests continues to yield previously unknown species.
Sensitivity of Satellite-Derived Tropospheric Temperature Trends to the Diurnal Cycle Adjustment
Authors: Mears Carl A. , Wentz Frank J. 
Published: March 2016

Abstract
Temperature sounding microwave radiometers flown on polar-orbiting weather satellites provide a long-term, global-scale record of upper-atmosphere temperatures, beginning in late 1978 and continuing to the present. The focus of this paper is the midtropospheric measurements made by the Microwave Sounding Unit (MSU) channel 2 and the Advanced Microwave Sounding Unit (AMSU) channel 5. Previous versions of the Remote Sensing Systems (RSS) dataset have used a diurnal climatology derived from general circulation model output to remove the effects of drifting local measurement time. This paper presents evidence that this previous method is not sufficiently accurate and presents several alternative methods to optimize these adjustments using information from the satellite measurements themselves. These are used to construct a number of candidate climate data records using measurements from 15 MSU and AMSU satellites. The new methods result in improved agreement between measurements made by different satellites at the same time. A method is chosen based on an optimized second harmonic adjustment to produce a new version of the RSS dataset, version 4.0. The new dataset shows substantially increased global-scale warming relative to the previous version of the dataset, particularly after 1998. The new dataset shows more warming than most other midtropospheric data records constructed from the same set of satellites. It is also shown that the new dataset is consistent with long-term changes in total column water vapor over the tropical oceans, lending support to its long-term accuracy.
Evaluation of platelet-rich plasma and fibrin matrix to assist in healing and repair of rotator cuff injuries: a systematic review and meta-analysis
Authors: Fu Chun-Jiang , Sun Jia-Bing , Bi Zheng-Gang , Wang Xu-Ming , Yang Cheng-Lin 
Published: March 2016

Objective: To perform a meta-analysis examining the effectiveness of platelet-rich plasma and platelet-rich fibrin matrix for improving healing of rotator cuff injuries. Data sources/design: A meta-analysis of eligible studies was performed after searching Medline, Cochrane, and EMBASE on 14 December 2015. Setting: University hospital. Participants: Patients with rotator cuff injuries. Review methods/intervention: Databases were searched using the keywords “PRP or platelet-rich plasma,” “PRFM or platelet-rich fibrin matrix,” “rotator cuff,” and “platelet-rich” for studies comparing outcomes of patients with rotator cuff injuries that did and did not receive a platelet-rich product. Main measures: The primary outcome was a functional score change from pre- to post-treatment (Scorepost–Scorepre). The secondary outcome was a visual analogue scale (VAS) pain score change from pre- to post-treatment (VASpost–VASpre). Results: A total of 11 studies were included in the meta-analysis. The total number of patients that received platelet-rich plasma or platelet-rich fibrin matrix was 320 and the number of control patients was 318. The standard difference in means of the functional scores was similar between patients administered platelet-rich plasma/fibrin matrix and patients in the control group (standard difference in means for functional scores = 0.029; 95% confidence interval (CI): –0.132 to 0.190; p = 0.725). The standard difference in means was similar between patients administered platelet-rich plasma and the controls (standard difference in means = 0.142; 95% CI: –0.080 to 0.364; p = 0.209). Conclusion: The results of this meta-analysis do not support the use of platelet-rich plasma/platelet-rich fibrin matrix in patients with rotator cuff injuries.
How sustainable development is understood in World Federation of Occupational Therapy policy
Authors: Jenkin Kathryn , Sellar Ben , Stanley Mandy , Thomas Kerry 
Published: March 2016

Introduction Sustainable development is used to tackle environmental crises affecting human survival. Many sectors endorse sustainable development as a guiding principle but the health sector is yet to incorporate it in an effective and coordinated manner. To support occupational therapy engagement, the World Federation of Occupational Therapy developed a policy outlining their position on sustainable development. Method The policy analysis method developed by Carol Bacchi (the ‘What’s the problem represented to be?’ approach) and elite interviewing of three members of the policy writing committee were used to explore how sustainable development is represented by the World Federation of Occupational Therapy and the effects of this representation. Results Analysis revealed that the World Federation of Occupational Therapy understands sustainable development as a set of principles and practices that demand cultural change. The policy links ‘Western’ cultural values and environmental crises and obliges occupational therapists, as ethical subjects, to take on new personal and professional values concerning knowledge, evidence and ethics. Conclusion Presently, occupational therapists adopting sustainable development principles may appear to be challenging unsustainable occupational therapy practices and expanding the parameters of professional ethics. Further research into the concept of the ethical subject and requirements necessary for the adoption of sustainable cultural values is suggested.
US Physicians Overwhelmingly Endorse Hospice as the Better Option for Most Patients at the End of Life
Authors: Prochaska Micah T. , Putman Michael S. , Tak Hyo Jung , Yoon John D. , Curlin Farr A. 
Published: February 2016

Background: Utilization of hospice has increased significantly over the past 2 decades, but there has been no recent assessment of US physicians’ opinions regarding and practices of referring patients to hospice. Methods: We surveyed 2016 US physicians from various specialties. Respondents agreed or disagreed with 2 statements: “For most patients, hospice provides better care at the end of life than they would otherwise receive without hospice” and “Many patients who enter hospice end up missing out on medical interventions from which they would have benefited.” Physicians were also asked, “In the past 12 months, approximately how many patients and/or their surrogates have you encouraged to consider entering hospice?” Results: Ninety-eight percent of physicians agreed that hospice provides better care at the end of life than the patient would receive without hospice. Only 11% of physicians agreed that patients who enter hospice miss out on medical interventions from which they would have benefitted. Ninety-two percent encouraged at least 1 patient to consider hospice in the previous 12 months. Oncologists were the most ambivalent about whether patients who enter hospice miss out on beneficial interventions, but they also referred more patients to hospice than physicians from other specialties. Conclusion: US physicians overwhelmingly believe hospice is the best form of care for most patients at the end of life. Compared to a study published in 1998, the median oncologist reports referring fewer patients to hospice, but the median general internist reports referring more.