bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of various RAS codon mutations and prognostic outcomes of patients with colorectal liver metastases after hepatectomy
Authors: Wu Xiao‐Gang , Liu Wei , Wang Yan‐Yan , Wang Kun , Xing Bao‐Cai 
Published: October 2024

AbstractPurposeThe prognostic and predictive value of RAS mutations in patients with colorectal liver metastases (CRLM) who have undergone hepatectomy holds substantial importance. The present study aimed to investigate the impact of different RAS codon mutations on long‐term survival in CRLM patients.MethodsA retrospective analysis was conducted on clinicopathological data from 399 CRLM patients with RAS mutations who underwent hepatectomy between January 2000 and December 2020. The RAS mutation gene status was assessed in KRAS codons (G12, G13, Q61, and A146) and NRAS codons (G12, G13, and Q61). Survival curves were generated using the Kaplan–Meier plotter and compared using the log‐rank test. Univariate and multivariate analyses were performed to analyze the clinicopathological data.ResultsIn the entire cohort, patients with KRAS G12 mutations exhibited the most favorable prognosis (p = 0.018). Comparatively, patients harboring KRAS Q61 mutations experienced poorer overall survival (OS) with a median of 15 months versus 33 months (p = 0.011) when compared to those with KRAS G12 mutations. Moreover, patients with NRAS Q61 mutations also showed decreased OS with a median of 26 months versus 33 months (p = 0.020) in comparison to KRAS G12 mutation patients. The results of multivariate analysis showed that both KRAS Q61 mutation (HR 2.130; 95% CI 1.088–4.168; p = 0.027) and NRAS Q61 mutation (HR 2.877; 95% CI 1.398–5.922; p = 0.004) were independent influencing factors of OS. Based on all identified risk factors, patients with RAS mutation were divided into high‐risk and low‐risk groups. Notably, in the high‐risk group, the incorporation of postoperative chemotherapy was associated with longer OS, while it did not improve the survival of patients in the low‐risk group.ConclusionsKRAS Q61 and NRAS Q61 mutations are promising predictors for OS in CRLM patients after hepatectomy. Postoperative chemotherapy may significantly benefit CRLM patients with RAS mutations, particularly those identified as high‐risk.
N‐doped Porous Carbon Derived from the Pyrolysis of a Polydopamine‐coated Hypercross‐linked Polymer for Enhanced CO2 Adsorption
Authors: Wang Jingtao , Liu Xiaoyan , Zhou Yang , Yang Zhuhong , Tegladza Isaac D. , Liu Chang 
Published: October 2024

AbstractPorous carbon materials can simultaneously capture and convert carbon dioxide, helping to reduce greenhouse gas emissions and using carbon dioxide as a feedstock for the production of valuable chemicals or fuel. In this work, a series of N‐doped porous carbons (PDA@HCP(x:y)‐T) was prepared; the CO2 adsorption capacity of the prepared PDA@HCP(x:y)‐T was enhanced by coating polydopamine (PDA) on a hypercross‐linked polymer (HCP) and then adjusting the mass ratio of PDA to HCP and the carbonization temperature. The results showed that the prepared PDA@HCP(1 : 1)‐850 exhibited a high CO2 adsorption capacity due to abundant micropores (0.6762 cm3/g), a high specific surface area (1220.8 m2/g), and moderate surface nitrogen content (2.75 %). Notably, PDA@HCP(1 : 1)‐850 exhibited the highest CO2 uptake of 6.46 mmol/g at 0 °C and 101 kPa. Critically, these N‐doped porous carbons can also be used as catalysts for the reaction of CO2 with epichlorohydrin to form chloropropylene carbonate, with chloropropylene carbonate yielding up to 64 % and selectivity of the reaction reaching 94 %. As a result, these N‐doped porous carbons could serve as potential candidates for CO2 capture and conversion due to their high reactivity, excellent CO2 uptake, and good catalytic performance.
Balanced Switchable Bandpass Filter With All‐Port Reflectionless and Common‐Mode Suppression Characteristics
Authors: Wang Zicheng , Wang Zhongbao , Liu Hongmei , Gao Mingming , Fang Shaojun 
Published: October 2024

ABSTRACTA novel balanced switchable bandpass filter with all‐port reflectionless characteristics is proposed in this paper. The balanced switchable bandpass filter comprises a balanced switchable filtering section with bandpass response and two absorptive networks. The absorptive network proposed in this paper adopts only one structure to achieve both differential‐ and common‐mode reflectionless characteristics. The proposed switchable resonators in the filtering section and the proposed absorption networks excited under even‐ and odd‐modes are analyzed in detail. For the purpose of verification, a prototype is manufactured based on the simulated results, and it has a good consistency. The experimental results exhibit that the proposed balanced bandpass filter exhibits a differential‐mode bandpass filtering function and all‐port reflectionless performance in the ON‐state, differential‐mode isolation function, common‐mode suppression, and reflectionless behavior in the OFF‐state, which verifies the feasibility of the design theory.
Energy Conscious Squirrel Search based Task Scheduling Mechanism in Fog Environment
Authors: Singh Raj Mohan , Sikka Geeta , Awasthi Lalit Kumar 
Published: October 2024

ABSTRACTThe swift explosion of Internet of Things (IoT) devices in the past few years has resulted in a deluge of data that requires timely processing. However, transmitting such massive amounts of data in and out from cloud leads to high latency and network bandwidth. Consequently, the field of fog computing has turned out as a feasible platform for utilizing resources within the vicinity of IoT devices for providing services in a timely manner. The resource constrained trait of fog nodes demands judicious management of resources in satisfying the requirements of IoT applications. This makes energy efficiency a core issue in fog networks. This article addresses the issue of energy efficiency by proposing an energy conscious squirrel search algorithm (EcSSA) for scheduling tasks in fog environment. A salient feature of EcSSA lies in the novel objective function that aims to optimize the energy consumption by minimizing the cumulative active time of all nodes in the network. Simulation studies conducted as part of this work demonstrate that the proposed approach significantly improves average energy consumption, average makespan, and carbon dioxide emission rate in comparison to the existing algorithms.
Folic acid ameliorates high glucose–induced neurotoxicity in human forebrain organoids: Insights from proteomics
Authors: Yan Haoni , Chen Shujin , Abdulla Aynur , Li Zhile , Zhuang Tsz Yui , Zhang Manlin , Wu Leqi , Zhang Yizhi , Ding Xianting , Jiang Lai 
Published: October 2024

AbstractPregestational diabetes (PGDM) has been associated with an elevated risk of congenital abnormalities, particularly those affecting the nervous system. The efficacy of folic acid (FA) supplementation in reducing the incidence of neurodevelopmental damage caused by PGDM has been well documented. However, the exact mechanism is unclear. Here, a human forebrain organoid model, which replicates the three‐dimensional structure of the early fetal neural tissue, was employed to study the neuroprotective effects of FA in PGDM. In this study, the forebrain organoids were cultured at high glucose (HG) concentrations from Days 20 to 40 with or without FA. Immunostaining revealed that the supplementation of FA significantly decreased HG‐induced neuron apoptosis. The proteomics examination suggested HG caused an increase in glial fibrillary acidic protein expression, a marker of astrocytes, leading to the upregulation of metallothionein expression and perturbation of mineral absorption, whereas FA reversed this effect. Proteomics analysis further showed that FA reduced HG‐induced cell migration. Moreover, Western blot analysis verified that FA mitigated HG‐induced apoptosis and cell migration via AMPK/FOXO pathway. Overall, current findings indicate that FA, as a functional food ingredient, has a protective effect on HG‐induced abnormal fetal neurodevelopment.
Tropical fruit‐derived starch: An innovative strategy for high‐value nutritional processing of agricultural solid waste
Authors: Lan Tian , Wang Jiaqi , Li Yongwu , Wang Yaguo , Sun Xiangyu , Fang Yulin , Ma Tingting 
Published: October 2024

AbstractTropical fruits are popular worldwide due to their appealing flavors and diverse health benefits. However, a significant amount of waste is caused by inferior fruits that are partly eliminated from the fresh fruit market and by‐products produced during transportation, storage, and processing. With increasing focus on environmental sustainability and resource conservation, recycling waste resources from tropical fruits has emerged as a hot topic of interest. Fruit‐derived starch is an emerging approach to adding value for some tropical fruit waste and inferior fruits. This review article briefly overviews extraction methods, chemical composition, structural characteristics, physical and chemical properties, physiological benefits, modification techniques, and potential applications of new tropical fruit‐derived starch. Compared with traditional starch, tropical fruit‐derived starch exhibits unique structural and processing attributes, making it suitable as a supplement or replacement for industrial starch in the food industry. Moreover, tropical fruit‐derived starch retains the rich nutrients and functional components present in fruits to some extent, thereby offering potential health benefits and greater consumer acceptance. Although current research on starch derived from tropical fruits is primarily at the laboratory stage, and there is limited exploration of its processing and application, evolving lifestyle trends and heightened health awareness are expected to foster its further development and utilization, paving the way for large‐scale commercialization and driving future market growth.
Outcomes and prognostic factors in 3306 patients with relapsed/refractory chronic lymphocytic leukemia treated with ibrutinib outside of clinical trials: A nationwide study
Authors: Rigolin Gian Matteo , Olimpieri Pier Paolo , Summa Valentina , Celant Simone , Scarfò Lydia , Ballardini Maria Pia , Urso Antonio , Gambara Silvia , Cavazzini Francesco , Ghia Paolo , Cuneo Antonio , Russo Pierluigi 
Published: October 2024

AbstractWe performed a cohort study that included all patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL) who received ibrutinib in the Italian National Health Service. With a median follow‐up of 42.2 months (IQR 30.8–54.6 months), the study involved 3306 patients with a median age of 72.1 years, of whom 42.6% had received ≥2 previous lines of treatment. The estimated 24‐month probabilities of being on treatment and alive were 57.9% (95% confidence interval [CI]: 59.6–56.2) and 76.6% (95% CI: 75.2–78.1), respectively. The median time to treatment discontinuation (TTD) was 31.3 months (95% CI: 29.5–33.5). Out of 3306 patients, 2015 (60.9%) discontinued treatment, with 993 cases attributed to death or disease progression (30.0% of all cases). Among the 1022 patients who discontinued treatment for reasons other than progression or death, 564 (17.1%) patients did so due to toxicity or medical decision, while 458 patients (13.8%) were lost to follow‐up. Multivariable analysis revealed that age, Eastern Cooperative Oncology Group Performance Status, the number of previous lines of therapy, refractoriness to the last treatment, and reduced renal function were associated with shorter TTD and overall survival (OS). The coexistence of 17p− and TP53 mutations had an independent unfavorable impact on TTD and OS. Nonstandard doses were associated with shorter TTD and advanced stage with shorter OS. The median OS postprogression and postdiscontinuation for other reasons were estimated at 12.9 (95% CI: 11.3–16.2) and 22.7 months (95% CI: 20.2–28.3), respectively. This large real‐world study shows that ibrutinib is an effective treatment for R/R CLL. Baseline patient characteristics and double‐hit TP53 aberrations were associated with inferior prognosis, and discontinuation due to CLL progression portended a poor outcome.
Inhibition of intestinal inflammation and fibrosis by Scutellaria Baicalensis georgi and Boswellia serrata in human epithelial cells and fibroblasts
Authors: Laudadio Ilaria , Leter Beatrice , Palone Francesca , Cucchiara Salvatore , Carissimi Claudia , Scafa Noemi , Secci Daniela , Vitali Roberta , Stronati Laura 
Published: October 2024

AbstractObjective and RationaleInflammatory bowel disease, including Crohn's disease and ulcerative colitis, manifests with chronic intestinal inflammation and frequent sequential fibrosis. Current pharmacological therapies may show harmful side effects and are not useful for prevention or resolution of fibrosis. Thus, the use of alternative therapies is emerging as a novel useful approach. Previous results suggest that Scutellaria baicalensis Georgi (SBG) and Boswellia serrata (BS) display anti‐inflammatory properties. The aim of this study was to investigate in intestinal epithelial cells and fibroblasts the anti‐inflammatory and anti‐fibrotic potential of SBG and BS, alone or in combination.MethodsHuman colorectal adenocarcinoma cells (HT29), human intestinal epithelial cells (HIEC6) and human colon fibroblasts (CCD‐18Co) were used. Cells were pretreated with SBG and BS and then exposed to pro‐inflammatory and pro‐fibrotic cytokines.ResultsSBG and BS extracts significantly decreased pro‐inflammatory cytokine expression and improved epithelial restitution in HT29 and HIEC6 cells. Besides, fibrotic marker expression, including SNAIL, ACTA2, ZNF281, was strongly reduced. Colon myofibroblasts treated with SBG and BS showed a significant decrease of fibrotic markers as well.ConclusionsSBG and BS extracts significantly reduce inflammation and impair fibrosis in intestinal epithelial cells and colon myofibroblasts. No cooperative effect is observed.
Bioinspired synthesis of ZrO2‐Zr3Er4O12‐based mixed nanomaterial; characterization and analyzing its potential as an electrode material in energy‐based devices and its electrocatalytic property
Authors: Azhar Sundus , Ahmad Khuram Shahzad , Abrahams Isaac , Ingsel Tenzin , Gupta Ram K. , Albaqami Munirah D. , Mohammad Saikh , Gul Mahwash Mahar 
Published: October 2024

AbstractThe sustainable and ecofriendly synthesis of transition metal oxide‐based nanomaterials has always been a matter of concern. In this study, a bioinspired synthesis route was adopted to synthesize ZrO2‐Zr3Er4O12‐based mixed nanomaterial using leaf extract of medicinal plant Amaranthus viridis as reducing and stabilizing agent in replacement of the obnoxious chemicals which are a great threat to the sustainable environment. The synthesized material revealed the spherical shaped morphology through scanning electron microscopy, whereas crystal size of 15.7 nm was observed through Xray‐diffraction, and band gap value of 2.7 eV was acquired using Tauc plot. Newly synthesized ZrO2‐Zr3Er4O12 nanocomposite was then investigated for its role as electrocatalyst in a generation of energy through the hydrogen evolution reaction and oxygen evolution reaction. The ZrO2‐Zr3Er4O12‐based electrocatalyst showed better potential for hydrogen evolution reaction measurements with the overpotential value of 242 mV. Furthermore, the notable capacitance value of 495.6 F/g was obtained through cyclic voltammetry for energy storage studies. The cyclic stability was also analyzed using linear sweep voltammetry and results showed promising stability for 2000 cycles. Consequently, the green and economical synthesis route as well as promising electrochemical behavior of ZrO2‐Zr3Er4O12‐based electrode make it feasible choice for large scale application.
Dried Blood Spots Sampling and Population Pharmacokinetic Modeling for Dosing Optimization of Piperacillin in Chinese Neonates
Authors: Li Pei , Chen Quanyao , Chen Yao , Zheng Zhi , Zhao Xiaoyan , Chen Huayan , Liu Qian , Xie Feifan 
Published: October 2024

AbstractPiperacillin is commonly used off‐label in neonates for the treatment of bacterial infections. This study aimed to assess a dried blood spots (DBS)‐based microsampling strategy for supporting population pharmacokinetics and treatment optimization of piperacillin in Chinese neonates. DBS samples from neonatal patients were collected at predefined intervals. Drug blood concentrations were quantified using a validated ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method. A population pharmacokinetic model was developed using a nonlinear mixed‐effects modeling approach. The pharmacokinetic/pharmacodynamics (PK/PD) target was 75% of the time with the unbound drug plasma concentration above the minimum inhibitory concentration (fT>MIC), with a toxicity threshold of unbound drug plasma trough concentration above 64 mg/L. A total of 45 piperacillin samples from 24 neonates were collected. The pharmacokinetics of piperacillin was described using a one‐compartment model with postmenstrual age (PMA) as the most significant covariate on clearance. Simulations showed that dosing regimens achieving >90% PK/PD target attainment with <10% risk of possible toxicity were: PMA 33‐35 weeks (50 mg/kg q12h), 35‐37 weeks (50 mg/kg q8h), and 37‐41 weeks (50 mg/kg q6h). In conclusion, Using DBS sampling, we developed a population pharmacokinetic model of piperacillin in Chinese neonates, incorporating PMA to determine optimal dosing regimens.
A localized approach for Turán number of long cycles
Authors: Zhao Kai , Zhang Xiao‐Dong 
Published: October 2024

AbstractLet be a simple graph and denote the length of the longest cycle containing an edge if there exists a cycle containing , and 2 otherwise. We prove that the summation of 2 divided by over all edges in an ‐vertex graph is at most , and characterize all ‐vertex extremal graphs that achieve the bound, thereby extending the classic Erdős–Gallai theorem on cycles.
Rapid Characterization of the Potential Active of Sinomenine in Rats by Ultra‐High‐Performance Liquid Chromatography‐Quadrupole‐Exactive Orbitrap Mass Spectrometry and Molecular Docking
Authors: Li Haixia , Li KaiLin , Cheng Wenhui , Liu Mingjuan , Wen Linwen , Zhang Zexu , Zhang Wendan , Su Jin , Cai Wei 
Published: October 2024

ABSTRACTSinomenium acutum (Thunb.) Rehd. et Wils is widely used in the treatment of rheumatoid arthritis, with its alkaloid compound sinomenine (SIN) being renowned for its significant anti‐inflammatory properties. However, despite its widespread application, the in vivo anti‐inflammatory mechanisms and metabolic pathways of SIN remain incompletely understood. This study established a rapid and reliable method based on an ultra‐high‐performance liquid chromatography method coupled with Quadrupole‐Exactive Orbitrap mass spectrometry and molecular docking to identify and characterize SIN and 69 metabolites in rat plasma, urine, and feces, revealing primary metabolic pathways of hydroxylation, demethylation, sulfation, and glucuronidation. Molecular docking results revealed that phase I reactions, including dedimethylation, demethylation, dehydrogenation, and dihydroxylation, along with their composite reactions, were pivotal in influencing SIN's in vivo anti‐inflammatory activity. M28, M36, and M59 are potentially the most anti‐inflammatory active metabolites of SIN in vivo. This comprehensive analysis unveils SIN's metabolic pathways, offering insights into its biological processes and suggesting a novel approach for exploring active drug constituents. These findings pave the way for further understanding SIN's anti‐inflammatory mechanisms, contributing significantly to the development of new therapeutic strategies.
Cost‐Effectiveness Analysis of Operating Room and In‐Office Reconstruction of Skin Cancer Defects
Authors: Sharma Rahul K. , Upton Montana , Vaidya Avi U. , Longino Elizabeth S. , Adegboye Feyisayo O. , Desisto Nicole G. , Stephan Scott J. , Yang Shiayin F. , Patel Priyesh N. 
Published: October 2024

AbstractObjectiveReconstruction of skin cancer and Mohs micrographic surgery (MMS) defects of the head and neck is performed in both in‐office and operating room (OR). This study intends to understand cost differences between reconstructive surgery for skin cancer defects in the OR and clinic to perform a cost‐effectiveness analysis with single‐institution patient satisfaction data.Study DesignPopulation‐based retrospective analysis of cost data and an institutional, prospective survey of patient satisfaction.SettingNational insurance database and institutional survey.MethodsThe Merative® MarketScan database was queried to identify claims involving the reconstruction of skin cancer defects of the head/neck between 2013 and 2020 for cost‐analysis by setting (OR vs clinic). Patients undergoing operative and clinic‐based reconstruction of MMS defects by 3 different surgeons at a single institution in 2023 were surveyed for satisfaction using a 5‐point Likert scale. Data was coupled for cost‐benefit analysis. Analysis was performed using propensity‐matched samples.ResultsUsing Marketscan, 1206 patients were analyzed for cost data. OR cases had a higher median baseline cost of $2308 (interquartile range [IQR]: 1484‐3889) compared to procedures in the office (median $987, IQR: 784‐1454, P < .001). Survey data from 116 patients revealed no significant difference in scores between OR and clinic cases (clinic: 4.57 vs OR: 4.60, P = .8752). Using propensity‐matched subsets, providers incur an additional $4744 for a reduction in satisfaction of 0.083 when performing cases in the OR.ConclusionLower cost is associated with reconstructive procedures performed in the office. This study is the first cost analysis of head and neck skin cancer reconstruction based on procedural settings and will be valuable to surgeons in considering practice patterns and resource utilization.
Unmasking Nasal Septal Hematoma/Abscess: A Systematic Review and Meta‐analysis
Authors: Nanu Douglas P. , Adelsberg Daniel , Nguyen Shaun A. , Radulovich Nicholas P. , Carr Michele M. 
Published: October 2024

AbstractObjectiveWe aim to discuss the demographics, symptoms, bacteriology, treatment, and sequelae associated with nasal septal hematoma/nasal septal abscess (NSH/NSA).Data SourcesCINAHL, PubMed, and Scopus were searched from inception until October 15, 2023.Review MethodsPreferred Reporting Items for Systematic Reviews and Meta‐analysis 2020 guidelines were followed. Inclusion criteria included patients who were diagnosed with a traumatic NSH/NSA. NSH/NSA due to surgical procedures was excluded. Demographics included N of patients, patient age, and gender. Symptoms, antibiotics given, bacteriology, and sequelae were analyzed. Meta‐analysis of continuous measures (mean, median), and proportions (%) with a 95% confidence interval (CI) was conducted.ResultsThirty studies (N = 598) were included. In total, 72.1% were males (95% CI: 67‐78). The total mean age was 21.6 years (range: 0.2‐85, 95% CI: 17.2‐26.1). The mean time from trauma to diagnosis was 8.2 days. Common symptoms at presentation included nasal obstruction/congestion at 60.3% (95% CI: 37.1‐81.4), nasal pain at 30.0% (17.2‐44.6), swelling at 20.4% (8.7‐35.5), headache at 15.5% (7.3‐26.0), and fever at 13.9% (7.3‐22.2). The most common pathogens isolated included Staphylococcus aureus at 56.5% (49.0‐63.8), Streptococcus species at 8.9% (5.2‐14.0), and Klebsiella pneumoniae at 6.3% (3.2‐10.8). Antibiotics given included amoxicillin‐clavulanate at 10.3% (4.5‐18.2), metronidazole at 9.5% (1.1‐24.9), ampicillin‐sulbactam at 8.9% (0.4‐26.5), and unspecified antibiotics at 39.7% (13.8‐69.2). The most common sequelae were nasal septal deformity/cartilage destruction at 14.3% (7.7‐22.6).ConclusionNSA/NSH has an 8‐day delay in diagnosis from the time of trauma. First‐line practitioners should be made aware of the signs and symptoms of this condition to minimize the risk of morbidity.