bluuebunny/crossref_metadata_2025_split huggingface dataset:
A century of NAD+ insights drives aging science and solutions innovations
Authors: Crews Rebecca , Makar Heather L 
Published: October 2024

A century of NAD+ insights drives aging science and solutions innovations
Dr. Rebecca Crews from Renue By Science, LLC, outlines a century of NAD+ insights driving aging science and, innovative solutions and much more. Nicotinamide adenine dinucleotide. NAD+ is essential for human health and is central to cellular metabolism, DNA repair, and many other essential operations. Over a century ago, its importance became clear when a deficiency in niacin, a precursor to NAD+, was linked to pellagra – a devastating disease characterized by dermatitis, diarrhea, dementia, and death. The diverse and severe symptoms of pellagra underscored just how crucial NAD+ is to the body’s basic functions.
Empowering voices: Breaking mental health stigma
Authors: Cannon Mary , Hoey John 
Published: October 2024

Empowering voices: Breaking mental health stigma
John Hoey and Mary Cannon from Department of Psychiatry, RCSI University of Medicine and Health Sciences, Dublin, Ireland, share their research around breaking mental health stigma to empower voices. Research consistently shows that people from marginalised groups are almost four times as likely to experience mental conditions such as psychotic symptoms than the majority population (van der Ven et al., 2022). Yet, they are much less likely to seek timely clinical intervention or reach out to friends and family for support. Why is this, and what can be done to encourage people to seek help? In our April 2024 blog “Can the Arts be an Effective Tool to Combat Psychosis Stigma,” we described stigma, as defined in the Oxford English Dictionary, as “Negative feelings that people have about particular circumstances or characteristics that somebody may have.” Although in recent years, attitudes towards certain mental conditions such as anxiety or depression have become more ‘normalised’ and openly discussed, other conditions, such as psychotic symptoms, remain stubbornly stigmatic and shrouded in fear. When it comes to mental health, those who both fear most, and are the subjects of fear, are marginalised groups, which can negatively impact both engagement and recovery.
Floreon technology, redefining polylactic acid
Authors: Gill Andrew , Garnier Sandrine 
Published: October 2024

Floreon technology, redefining polylactic acid
Dr Andrew Gill, CTO, and Dr Sandrine Garnier, CEO of Floreon Technology Ltd., explain how the company is redefining Polylactic Acid, starting with who they are and what they offer. Floreon Technology is an innovative company that emerged from a successful KTP (Knowledge Transfer Partnership) with the University of Sheffield in the UK. Floreon’s technical team has developed expertise in using Polylactic Acid (PLA) to produce a highly robust line of biopolymers for engineering purposes.
Intra-operative imaging solutions for surgeons
Authors: Dresp Birgitta 
Published: October 2024

Intra-operative imaging solutions for surgeons
Birgitta Dresp from the Centre National de la Recherche Scientifique (CNRS) discusses the challenges associated with intra-operative imaging technology and the quest for gold standards of surgical skill. In minimally invasive interventional procedures such as laparoscopic surgery, surgeons do not have a direct view of the organ or tissue they are interacting with but are constrained to navigate the surgical instruments on the basis of image views provided by dedicated camera systems. Image-guided interventions have been on the rise in recent years as they are less invasive than traditional methods and are believed to enable more accurate surgical gestures. Yet, the surgeon’s brain needs to re-interpret the visual information available in the image given. This has to be achieved swiftly and reliably for controlling the instruments with the greatest ease and accuracy, yielding the most precise surgical gestures in the shortest time possible. How can we assess critical parameters of surgical skill and its evolution with time and training under different conditions imposed by different technological solutions?
Agricultural terraces in Europe: Geoarchaeological and botanical methods
Authors: Brown Tony , Pears Ben , Cucchiaro Sara , Fallu Daniel 
Published: October 2024

Agricultural terraces in Europe: Geoarchaeological and botanical methods
Tony Brown, Dan Fallu, Sara Cucchiaro, Ben Pears, and the TerrACE Team, highlight agricultural terraces in Europe, providing geoarchaeological and botanical insights. Agricultural terraces exist in all countries in Europe but, particularly those with hilly regions where terraces can significantly increase the area of high-quality cultivatable land. Terraces, which are also common worldwide, are the largest human-made manipulations of the earth’s surface prior to the building of cities and are known to provide beneficial ecosystem services, including long-term carbon storage. Despite this remarkably little is known about their history, and in many cases, what crops they were originally created for. They are also exceptionally resilient, mostly surviving since their first construction to the present day. However, this is changing as since the development of the caterpillar-tracked bulldozer, many have been destroyed.
Trustworthy AI for semiconductor manufacturing
Authors: van Gerven Marcel 
Published: October 2024

Trustworthy AI for semiconductor manufacturing
Marcel van Gerven, a Professor of Artificial Cognitive Systems at Radboud University, discusses how his team’s research on AI models, algorithms, and demonstrators could serve as a blueprint for the semiconductor manufacturing industry. Artificial Intelligence (AI) is a key enabling technology that, when used responsibly, can bring about significant positive societal impact. One of the initiatives to foster this positive impact is the Dutch ROBUST ‘Trustworthy AI-based Systems for Sustainable Growth’ program. This ten-year Long Term Program (LTP) is a human- centered research program in AI that brings together knowledge institutes, industry, governmental organizations, and societal partners to develop AI-based methods and tools designed to create social impact and promote sustainable growth (Figure 1).
Filicide: The most tragic family violence event
Authors: Brown Thea 
Published: October 2024

Filicide: The most tragic family violence event
Thea Brown, Professor Emeritus AM from Monash University, Caulfield in Australia, guides us through filicide, the most tragic family violence event. Filicide, the killing of a child or children by a parent, stepparent or equivalent guardian, is a tragic international problem, provoking shock and horror in the child’s family and the wider community. Often thought of as rare, incidence studies show it is not (Brown, Lyneham, Bryant, Tomison, Tyson, Fernandez Arias, Bricknell, 2019; Dawson, 2019; Buiten, 2022). Moreover, incidence has been shown to be alarmingly high in some more affluent nations, like the United States, Australia, and New Zealand (Pritchard, Davey, and Williams, 2013).
Hormonal contraceptives and women’s mental health – A long-term perspective
Authors: Pletzer Belinda 
Published: October 2024

Hormonal contraceptives and women’s mental health – A long-term perspective
Belinda Pletzer of the University of Salzburg discusses the importance of researching the mental health effects of hormonal contraceptives and the need to identify women at risk for adverse mood reactions before they start hormonal contraception. The mental health effects of hormonal contraceptives have received much media attention over the last decade, resulting in increased skepticism towards hormonal treatments and a reduction in hormonal contraceptive use. Recognizing hormonal contraceptives as a potential trigger of mood symptoms was a crucial and empowering step for women’s mental health research and care. However, we still need to find a balance in weighing the reproductive – and probably also mental – health benefits of hormonal contraceptives against the risks of adverse reactions. Information is key to achieving that goal. Thus, research into the mental health effects of hormonal contraceptives is of utmost importance.
Mechanical energy at the origins of life
Authors: Hansma Helen Greenwood 
Published: October 2024

Mechanical energy at the origins of life
Did mechanical energy power life’s origins before chemical energy such as ATP was available?. Mechanobiology is a hot topic in science today, with special issues on the subject in scientific journals. Was mechanical energy a way to form chemical bonds before the origin of life made mechanobiology possible? This makes a lot of sense, because life was not around yet to synthesize ATP (adenosine triphosphate), the chemical energy molecule that powers many of the processes of life. With mechanochemistry, molecules are simply smashed together to form covalent bonds between them (Figure 1). Mica sheets provide mechanical energy at their split edges and bubbles between the sheets (1-3), as shown in this photograph of a piece of mica (Figure 2) and the diagram of mica in Figure 3.
Understanding and predicting the intergenerational transmission of mental illness
Authors: Karguth Nina , Houtum Lisanne A.E.M. van , Fegert Jörg M , Schlaegel Karen , Raballo Andrea , Saunders John , Decraene André , Haren Neeltje E.M. van 
Published: October 2024

Understanding and predicting the intergenerational transmission of mental illness
The FAMILY consortium aims to improve the lives of mentally ill persons and their families by focusing on understanding the mechanisms of intergenerational transmission of mental illness from parent to child. Children of mentally ill parents are more likely to develop a mental illness themselves. However, this does not imply that the majority of these children become unwell. The fact that mental illness may run in families (aka intergenerational transmission of mental illness) has been acknowledged for decades. Yet, it has not received adequate attention in clinical and research settings. This leads to consequent delays in identifying mental health issues in young children and missing opportunities for prevention. Although most mentally ill individuals are aware that their mental illness can affect their offspring, healthcare professionals rarely discuss this with them. Moreover, most therapies focus on individual recovery, disregarding the impact on families and children. Coupled with the fear of stigma, barriers arise for both parents and children to seek professional help.
Personalized medicine beyond cancer: Impact on other diseases
Authors: Hays Priya 
Published: October 2024

Personalized medicine beyond cancer: Impact on other diseases
With a focus on type 2 diabetes and Parkinson’s disease, Dr Priya Hays explores how personalized medicine approaches are impacting the development of therapies for other chronic conditions beyond cancer. Genetic testing and cancer outcomes have been considerably advanced by precision medicine, or personalized medicine, with gene panel testing conducted routinely in patient care and targeted therapy approaches incorporated into oncology. It may be argued that with these significant advances, diseases such as type 2 diabetes, cardiovascular disease, neurological diseases such as Parkinson’s disease, and Alzheimer’s disease and psychiatric diseases have been unaffected by the gains of personalized medicine. However, this is not entirely accurate as aspects of personalized medicine such as pharmacogenomics, targeted approaches for neurological systems, and single nucleotide polymorphism detection have resulted in safe and effective diagnostics and treatments for cardiovascular disease, diabetes and neurological disorders, and depression and schizophrenia. Outlined here are precision medicine approaches for type 2 diabetes and Parkinson’s disease.
Harnessing hybrid molecules for drug development
Authors: Nikolova Stoyanka , Stefanova Iliyana , Gledacheva Vera , Milusheva Miglena 
Published: October 2024

Harnessing hybrid molecules for drug development
Stoyanka Nikolova, Professor from Paisii Hilendarski Plovdiv University, discusses the potential of harnessing hybrid molecules for drug development and their possible application in addressing the clinical challenge of irritable bowel syndrome. Irritable bowel syndrome (IBS) remains a clinical challenge. It’s the most common gastrointestinal disorder. IBS has no definitive treatment but could be controlled by non-pharmacologic management, eliminating some exacerbating factors such as certain drugs, stress conditions, and changes in dietary habits. Intestine peristaltic reflexes and sensory relays are significantly regulated by serotonin, predominantly found in intestine enterochromaffin cells.
GERICS supporting climate-resilient wind energy sites
Authors: Cetin Irem Isik , Keup-Thiel Elke 
Published: October 2024

GERICS supporting climate-resilient wind energy sites
Dr. Irem Isik Cetin and Dr Elke Keup-Thiel offer expert insights on how GERICS supports the climate-resilient development of wind energy sites. Since the oil crisis in 1973, the use of modern wind turbines has clearly grown. By 2023, the installed capacity of wind energy globally surpassed 1 terawatt (TW). (1) With low costs and high emission reduction potential (2), wind energy has emerged as one of the most promising options for moving towards a low-carbon energy transition. For this reason, after COP28, more than 200 countries aimed to triple renewable energy capacity.
The role of ambiance and service in culinary tourism: A case study at D’Warung
Authors: Sukartini Ni Wayan , Kanca I Nyoman , Budiarta I Putu , Sumawidari Ida Ayu Ketut 
Published: October 2024

This study examines the culinary and dining experience at D’Warung, a popular restaurant known for its diverse menu and cozy atmosphere. The primary objective is to analyze the restaurant's appeal, focusing on its food offerings, ambiance, and customer service. Data collection was conducted through observation and interviews with staff and customers, assessing factors such as the quality of the food, the level of crowd, and the friendliness of the service. The results reveal that D’Warung stands out for its comfortable atmosphere, friendly staff, and a varied menu that includes both local and western dishes. The analysis highlights these factors as key contributors to the restaurant’s success. In conclusion, the study emphasizes the importance of creating a welcoming environment and providing excellent service in shaping a memorable dining experience.
ผลการจัดกิจกรรมนิทานประกอบท่าโยคะเพื่อส่งเสริมทักษะความจำเพื่อการใช้งานของเด็กปฐมวัย
Authors: ลีอ่ำ นุจรี , แสวงเจริญ เพ็ญศรี , บุตรกตัญญู อรพรรณ 
Published: October 2024

ภูมิหลังและวัตถุประสงค์: ความจำเพื่อการใช้งานเป็นการทำงานของสมองที่มีบทบาทสำคัญต่อความสามารถในการเรียนรู้ การให้เหตุผล และการแก้ปัญหา ทักษะความจำเพื่อการใช้งานจะพัฒนาเมื่อเด็กเริ่มเติบโตขึ้น มีหลากหลายกลยุทธ์ในการส่งเสริมทักษะความจำเพื่อการใช้งานของเด็ก การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อ 1) ศึกษาผลการจัดกิจกรรมนิทานประกอบท่าโยคะเพื่อส่งเสริมทักษะความจำเพื่อการใช้งานของเด็กปฐมวัย 2) เปรียบเทียบทักษะความจำเพื่อการใช้งานของเด็กปฐมวัยก่อน และหลังการจัดกิจกรรมนิทานประกอบท่าโยคะเพื่อส่งเสริมทักษะความจำเพื่อการใช้งานของเด็กปฐมวัย
ระเบียบวิธีการวิจัย: กลุ่มตัวอย่างเป็นเด็กปฐมวัยชาย-หญิงที่มีอายุระหว่าง 5-6 ปีที่กำลังศึกษาอยู่ระดับชั้นอนุบาลปีที่ 2 ภาคเรียนที่ 2 ปีการศึกษา 2566 โรงเรียนหนองจอกพิทยานุสรณ์ กรุงเทพมหานคร จำนวน 30 คน โดยการสุ่มตัวอย่างแบบแบ่งกลุ่ม เครื่องมือวิจัยประกอบด้วยแผนการจัดกิจกรรมนิทานประกอบท่าโยคะเพื่อส่งเสริมทักษะความจำเพื่อการใช้งานของเด็กปฐมวัย และแบบประเมินทักษะความจำเพื่อการใช้งานของเด็กปฐมวัย สถิติที่ใช้ในการวิเคราะห์ข้อมูลคือค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน ค่าร้อยละ และ t-test (dependent sample)
ผลการวิจัย: ผลการวิจัยพบว่าก่อนการทดลองเด็กปฐมวัยส่วนใหญ่มีทักษะความจำเพื่อการใช้งานอยู่ในระดับน้อยมาก คิดเป็นร้อยละ 50.00 รองลงมาคือระดับน้อย คิดเป็นร้อยละ 26.67 ระดับดี คิดเป็นร้อยละ 20.00 และระดับปานกลาง คิดเป็นร้อยละ 3.33 หลังการทดลองเด็กปฐมวัยส่วนใหญ่มีทักษะความจำเพื่อการใช้งานอยู่ในระดับปานกลาง คิดเป็นร้อยละ 40.00 รองลงมาคือระดับดีมาก คิดเป็นร้อยละ 30.00 ระดับดี คิดเป็นร้อยละ 26.67 และระดับน้อย คิดเป็นร้อยละ 3.33 คะแนนทักษะความจำเพื่อการใช้งานของเด็กปฐมวัยก่อนการจัดกิจกรรมนิทานประกอบท่าโยคะมีค่าเฉลี่ย 4.63 ค่าเบี่ยงเบนมาตรฐาน 2.04 และหลังการจัดกิจกรรมนิทานประกอบท่าโยคะมีค่าเฉลี่ย 8.13 ค่าเบี่ยงเบนมารตฐาน 1.76 เมื่อเปรียบเทียบความแตกต่างของคะแนนทักษะความจำเพื่อการใช้ของเด็กปฐมวัย พบว่าคะแนนทักษะความจำเพื่อการใช้งานของเด็กปฐมวัยหลังการจัดกิจกรรมนิทานประกอบท่าโยคะสูงขึ้นอย่างมีนัยสำคัญทางสถิติที่ระดับ .05
สรุปผล: เด็กปฐมวัยมีทักษะความจำเพื่อการใช้งานสูงขึ้นหลังการจัดกิจกรรมนิทานประกอบท่าโยคะเพื่อส่งเสริมทักษะความจำเพื่อการใช้งานของเด็กปฐมวัย
Outcomes of operative fixation of loose trochlear osteochondral defects: A case series with subgroup analysis
Authors: Bustamante Galo , Iyer Amogh , Milliron Eric , Cavendish Parker , Qin Charles , Duerr Robert , Magnussen Robert , Kaeding Christopher , Flanigan David 
Published: October 2024

Objectives To evaluate results of open reduction and internal fixation (ORIF) of loose osteochondritis dissecans (OCD) fragments of the trochlea including identification of any cases of fixation failure and assessment of post-operative patient-reported outcomes and activity level. Methods A retrospective chart review of OCD fixation surgeries performed between 2010 and 2021 identified 12 patients who underwent ORIF of loose OCD trochlear fragments. Patient demographics, history, imaging findings, surgical factors, and skeletal maturity were all collected. Primary outcome measures included reoperation for fixation failure, Knee Osteoarthritis Outcome Scores (KOOS), and Marx scores. Results The 12 patients (12 knees) with a mean age of 17.7 ± 6.4 years (range, 13-37 years) were included in the case series. Mean trochlear OCD size was 3.20 cm2 (range, 1.69-5.06 cm2) with mean follow-up of 78.9 months (range, 8 – 145). Failure of fixation occurred in. Failure of fixation occurred in 2 patients (17%). Of the 10 patients (83%) who completed PROs, the mean KOOS global score for all patients was 86.8 ± 16.3, symptoms/stiffness sub score 90.0 ± 11.0, pain 91.2 ± 12.1, Functions of daily living 95.5 ± 8.3, Sports/recreation 82.0 ± 23.9, quality of life 75.7 ± 28.6, and a mean Marx activity score of 10.5 ± 4.9. Conclusion ORIF of loose OCD lesions of the trochlea is associated with a low risk of failure of fixation and acceptable patient-reported outcomes.
IMPLICATIONS AND CONSIDERATIONS OF THE NEW ELECTRONIC INFORMATION AND TRANSACTION LAW
Authors: Purwono Agus , M. Zamroni M. Zamroni , Santoso Hardi Anugrah , Miarsa Fajar Rachmad Dwi 
Published: October 2024

Regarding regulations related to the electronic world, the purpose of this study is to link the law on Electronic Information and Transactions (ITE Law) No. 1 of 2024 which is the second amendment to Law No. 11 of 2008. The emergence of various problems regarding the ambiguity of protection in the scope of ITE has caused the public to urge the government to revise it as soon as possible. The methodology used in this study is normative juridical type sourced from primary and secondary legal materials. With an approach through legislation (Statute Approach) and a historical approach (Historical Approach). The Law on Information and Electronic Transactions which was born in 2008 (ITE Law No. 11 of 2008) contains provisions governing the electronic realm. Apart from that, the ITE Law has many weaknesses that conclude multiple interpretations of the contents of the article. To overcome this, the government made the first revision contained in Law No. 19 of 2016. The emergence of controversy has not been able to answer the changes in the first change. So there are still articles that reap pros and cons in the form of interpretation. Among them are Article 27, Article 28, Article 29, and Article 36. So the government made a second revision contained in Law No. 1 of 2024.
Avaliação da ocorrência de parasitos em fezes caninas coletadas em praças públicas do município de Taubaté – SP
Authors: Coêlho Matheus , Vieira da Silva Denis , Lourenço de Carvalho Romeiro Luciana , Pâmela Martins da Silva Fernanda , Paula Guedes Josiane , Miranda de Paula Marina , Alves da Silva Coêlho Francine 
Published: October 2024

Os cães (Cannis familiaris) consistem nos animais domésticos mais estimados pela população brasileira, porém algumas pecliaridades relacionadas aos hábitos higiênicos e sanitários dos mesmos e dos seus donos, traz a tona um risco para que haja transmissão de doenças zoonóticas, dentre as quais algumas doenças parasitárias. No presente estudo objetivou-se avaliar a presença de parasitos em fezes de cães coletadas em praças públicas do município de Taubaté, visando identificar os principais parasitos que podem representar riscos à saúde pública, devido à sua capacidade de infectar tanto animais quanto seres humanos. Para a realização do estudo, foram coletadas amostras de fezes caninas em diversas praças do município de Taubaté e para análise das amostras foi utilizado o método de Ritchie modificado. Observou-se uma ocorrência de 17,5% de amostras positivas, com destaque para Ancylostoma spp. , que foi diagnosticado em 50% das amostras positivas, trazendo a tona a necessidade da adoção de medidas prventivas aplicáveis para diminuir o risco de infecção, não só de cães, como também de seres humanos.
Exploring the Construction of Angela Merkel's Identity by Global Print Media across International Platforms
Authors: Ali Muhammad , Jamshed Humaira , Dost Khyzer Bin 
Published: October 2024

This study is an attempt to observe and analyze the intricate operations of media discourses in the identity construction of “world leader” i.e. Angela Merkel. It highlights that how through the explicit and implicit discourse layers’ construction, the macro and micro semantic structures are created in a newspaper, for portraying the desired positive or negative image of a world leader. The theoretical framework has been structured over the basics of the Van Dijk’s (1980) The Theory of Semantic Macrostructures. The macro- level analysis focuses the core themes and main propositions publicized in the selected data. The micro-level analysis concentrates on the lexicalization and syntactic patterns employed by media experts in creating the larger positive image as world leader through smaller level discourse language constructions, focusing her social and political posterities. Furthermore, the study highlights the gradually constructed personal, social and political identities’ portrayal of Angela Merkel as a powerful world leader, through the world newspaper articles discourse and discursive practices.
Data on the Sense of Coherence Among Nurses
Authors: Shamim Iqra , Mushtaq Humaira , Muslim Naiba , Akmal Pawan 
Published: October 2024

The purpose of this study is to determine the sense of coherence among nurses and its effect on nurses’ relationship with patients. And how therapeutic relationship affected by the coping mechanism of the nurses. The data were collected by using the questionnaires adapted from the previous studies. The study is cross sectional and quantitative using a deductive approach. Population of the study was the nurses and convenient sampling method used for collecting data. Sample size was 191 nurses. Finally, 119 valid questionnaires were used for data analysis. The result of my study is positive that is nurses with stronger sense of coherence can successfully develop a nurse patient interaction which benefits the both the nurses and the patients. Because stress and anxiety directly affect the nurses performance those who can manage the work related stressors more productively can do better as compare to those who fails to cope with depression. From the results of the study, it is concluded that the stronger sense of coherence resulted in the better coping mechanism in response to any stress or fears related to work and eventually they maintained good nurse patient therapeutic relationship.