bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lithium Plating Using a Thermoplastic Vulcanizate Electrolyte
Authors: Costalin Mehdi , Barcha Cédric , Rousselot Steeve , Foran Gabrielle , Nicolle Paul , Prébé Arnaud , Dollé Mickael 
Published: September 2024

Lithium metal anodes have generated significant interest due to their high theoretical capacity. However, issues such as dendrite growth or cell failure caused by lithium loss with either liquid electrolytes or solid polymer electrolytes (SPEs) have hindered its widespread commercialization. In this work, we report on the electrochemical characterization of symmetric Li-SPE-Li cells made with a thermoplastic vulcanizate electrolyte, PCl:HNBR LiTFSI. Full plating of the lithium metal (LiM) electrode was achieved at 100 μA.cm−2 in pressurized pouch cells. This was confirmed ex situ using scanning electron microscopy which showed the absence of dendrites. The Sand equation was employed at higher current densities to determine that the lithium diffusion coefficient at 60 °C is 1.7 × 10−8 cm2.s−1. The calculated threshold current density j* was approximately 200 μA.cm−2. The determination of the theoretical current density limit may provide critical information for the understanding of the behavior of cathode materials during cycling with lithium metal. Cell failure at high polarization or from short circuiting was experimentally confirmed in symmetric Li-Li cells where 100 cycles were performed at a current density below j* with 0.1 mAh.cm−2 of charge per cycle, while 0.5 mAh.cm−2 of charge rapidly induced cell failure.
An Observational Study on the Clinical Characteristics and Prognosis of Patients With Interstitial Lung Disease Secondary to Dermatomyositis and Antisynthetase Syndrome
Authors: Lei Ling , Ma Zongbo , Ma Xuejia , Pan Dongmei , Chen Zhanrui , Qin Fang , Dong Fei 
Published: September 2024

Objective: Identify the clinical characteristics and prognostic factors in patients with idiopathic inflammatory myopathy (IIM) combined with interstitial lung disease (ILD).Methods: IIM‐ILD patients who were hospitalized at Guangxi Medical University from January 2017 to December 2022 were retrospectively analyzed and classified as having dermatomyositis (DM)‐ILD or ‐ILD. Clinical and laboratory results were analyzed.Results: There were 39 males and 111 females, the mean age of disease onset was 50.4 ± 12.3 years, and the median disease duration was 3 months (range: 1–6). Ninety‐seven patients had DM‐ILD, and 53 had ASS‐ILD. The DM‐ILD group had 72% positivity for the anti‐MDA5 antibody and 5.2% positivity for the anti‐Mi‐2 antibody; the ASS‐ILD group had 67.9% positivity for the anti‐Jo‐1 antibody and 17% positivity for the anti‐EJ antibody. Muscle symptoms, skin ulcers, rash, rapidly progressing interstitial lung disease (RP‐ILD), and elevated levels of serum carcinoembryonic antigen were more common in DM‐ILD patients (all p < 0.05). However, pericardial effusion and pleural effusion, elevated creatinine kinase, and elevated C‐reactive protein were more common in ASS‐ILD patients. After a median follow‐up of 15.5 months, there were more deaths in the DM‐ILD group (42.3% vs. 13.2%, p < 0.001). Multivariate Cox regression analysis showed that RP‐ILD, dyspnea, and the usual interstitial pneumonia type of ILD had negative associations with overall survival (OS), and arthralgia had a positive association with OS (all p < 0.05).Conclusion: DM‐ILD patients were more prone to secondary RP‐ILD and skin ulcers, had milder symptoms of myositis and less severe serositis, and had lower survival rates than the ASS‐ILD patients. RP‐ILD, dyspnea, and the usual interstitial pneumonia type of ILD had adverse effects on prognosis, but arthralgia was a protective factor.
Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Authors: Du Yushen , Salehi-Rad Ramin , Zhang Tian-hao , Crosson William P. , Abascal Jensen , Chen Dongdong , Shi Yuan , Jiang Hong , Tseng Yen-Wen , Ma Xi , Hong Mengying , Wang Sihan , Wang Xijuan , Tang Kejun , Hu Shiyao , Li Yuting , Ni Shaokai , Cai Yiqi , Tappuni Shahed , Shen Yong , Liu Bin , Sun Ren 
Published: September 2024

Abstract
Despite recent advances in immunotherapy with immune checkpoint inhibitors, many patients with non–small cell lung cancer (NSCLC) fail to respond or develop resistance after an initial response. In situ vaccination (ISV) with engineered viruses has emerged as a promising antigen-agnostic strategy that can both condition the tumor microenvironment and augment antitumor T-cell responses to overcome immune resistance. We engineered a live attenuated viral vaccine, hyper–IFN-sensitive (HIS) virus, by conducting a genome-wide functional screening and introducing eight IFN-sensitive mutations in the influenza genome to enhance host IFN response. Compared with wild-type influenza, HIS replication was attenuated in immunocompetent hosts, enhancing its potential as a safe option for cancer therapy. HIS ISV elicited robust yet transient type I IFN responses in murine NSCLCs, leading to an enrichment of polyfunctional effector Th1 CD4+ T cells and cytotoxic CD8+ T cells into the tumor. HIS ISV demonstrated enhanced antitumor efficacy compared with wild-type in multiple syngeneic murine models of NSCLC with distinct driver mutations and varying mutational burden. This efficacy was dependent on host type 1 IFN responses and T lymphocytes. HIS ISV overcame resistance to anti–PD-1 in LKB1-deficient murine NSCLC, resulting in improved overall survival and systemic tumor-specific immunity. These studies provide compelling evidence to support further clinical evaluation of HIS as an “off-the-shelf” ISV strategy for patients with NSCLC refractory to immune checkpoint inhibitors.
The Impact of Children's Health Shocks on Parents' Labor Earnings and Mental Health
Authors: Breivik Anne-Lise , Costa-Ramón Ana 
Published: September 2024

Abstract
We provide novel evidence on the causal impact of a child's health shock on parents' labor market outcomes. Using high-quality Finnish and Norwegian administrative data, we construct counterfactuals for treated households with families who experience the same shock in later years. We find a sharp break in mothers' earnings trajectories after the event, while we do not find significant effects for fathers. Our findings do not align with the hypothesis of household specialization explaining these adjustments. Instead, the evidence suggests that these changes are driven by increased caregiving demands, with mothers bearing the primary burden. We also document a substantial impact on parents' mental well-being.
The Development of Four Adverbs of Degree from Old to Early New High German
Authors: Visser Lourens 
Published: September 2024

Abstract
The present study analyses four prominent adverbs of degree in Old, Middle, and Early New High German from a comparative West Germanic perspective: filu/vile/ viel ‘much, very’, harto/harte/hart ‘very, firmly’, sêro/sêre/sehr ‘very, sorely’, and gar(aw)o/gar(w)e/gar ‘wholly, very’. Based on corpus data, all four display considerable changes in their usage patterns over time. The findings support the observation that the Middle Germanic period was a time of convergence with regard to the usage of adverbs of degree (Visser 2023), since the developments in Low German largely follow those in High German. However, the geographic and textual distribution of sêro/sêre/sehr with the meaning ‘very’ in High and Low German suggests an expansion from Middle Dutch beginning around 1400. A broader implication is that usage patterns of adverbs of degree are quite borrowable in language contact situations.
Dreaming of the World to Come
Authors: Chandler Kegan A. 
Published: September 2024

Abstract
In comparative studies, Tenrikyō’s this-worldly, millenarian vision has found little resonance with Christian expectations of going to heaven after death. However, an “earthly turn” in Christian eschatology is redirecting Christian expectations away from heaven and toward bodily resurrection into an earthly Kingdom of God, providing new opportunity to revisit the potential historical and conceptual overlap between Tenrikyō’s view of earthly renewal and that of Christianity—in both its first-century and contemporary “restorationist” forms. This article considers the historical origin of Tenrikyō’s millenarianism against a backdrop of late-Tokugawa yonaoshi (world renewal) and Miroku-based movements. Here, the timeline for the appearance of millenarian views of yonaoshi proposed by Miura (2019) is revised to give Tenrikyō’s foundress primacy as a millenarian innovator. I furthermore suggest that monotheism may have been a catalyst for millenarian yonaoshi development. Finally, I propose “yonaoshi millenarianism” as a cross-cultural, comparative category applicable to both Tenrikyō and early/restorationist Christianity.
Consumer acceptance of different insect-based foods: a cross-cultural study in China and France
Authors: Yan X. , Federighi M. , Cappelier J.M. , Jury V. , Boué G. 
Published: September 2024

Abstract
Consumption of edible insects as an alternative protein source has recently gained attention for its potential beneficial impacts on the environment, nutrition, and food security compared to traditional sources. However, despite being a traditional food in some parts of the world, its acceptance is still limited, especially in Europe. The present study aims to examine consumers’ willingness to eat (WTE) different insect-based foods (IBF) and investigate determining factors for acceptance in countries with or without entomophagy traditions. An online cross-cultural survey was conducted in France (n = 515) and China (n = 594) in April 2023. Several explanatory variables were established, and their effects on the acceptance of insect foods was analysed by applying multiple linear regression. The results showed that Chinese respondents had higher willingness to eat insects than French respondents, with a different preference ranking of thirteen IBFs. In both countries, significant predictors of consumers’ willingness to eat insects were the low insect visibility, low food neophobia and disgust level, previous experience of consuming insects and knowledge of insects’ nutritional and environmental benefits. Consequently, the inclusion of insects in the daily diet of French and Chinese consumers requires a transitional phase to familiarize consumers with processed foods containing invisible insects and establish positive perceptions of insect foods.
Deep Reasonable Pluralism, Political Confucianism, and the Right to Toleration
Authors: Li Zhuoyao 
Published: September 2024

Abstract
This paper connects what I call deep reasonable pluralism, political Confucianism, and the right to toleration and argues that if deep reasonable pluralism is to be taken seriously, the domain of the political must assume some form of political neutrality that necessitates the right to toleration. Specifically, I will first argue that the significance of understanding pluralism in the context of East Asia lies not so much in finding out exactly how pluralistic East Asian societies are but rather how the co-existence of liberalism and Confucianism requires a deep view of reasonable pluralism. Second, I will argue that the right to toleration can be justified by appealing to the reasonableness of citizens without subscribing to any specific comprehensive doctrine. Third, distinguishing between a strong and a weak view of political neutrality, I will argue that taking deep reasonable pluralism seriously inevitably leads to a form of political neutrality, which effectively sets the limit for how Confucian a Confucian state can be without sacrificing non-Confucian citizens’ right to toleration.
Stability performance of an Algerian Ni/purified diatomite catalyst in the dry reforming methane reaction: characterization and properties
Authors: Adjissa Massinissa , Bouzidi Nedjima , Ikkour Kahina , Ouhenia Salim , Benlounes Ouarda , Lamrani Nouara 
Published: September 2024

AbstractThis work aims to characterize and study the properties of an Algerian diatomaceous earth (Sig-Mascara) as a catalyst carrier. A commercial product of diatomite was characterized by granulometric analysis, X-ray fluorescence, X-ray diffraction, Fourier-transform infrared spectroscopy, thermogravimetric analysis/differential scanning calorimetry and scanning electron microscopy/energy-dispersive X-ray spectroscopy methods. To purify the diatomite and remove the impurities (iron oxides, clay minerals, quartz and organic matters), the <63 μm fraction of the diatomite was separated out. The 15Ni/Ds-700 catalyst has lower SiO2, Al2O3and CaO contents compared with the original diatomite. The NiO content of the catalyst is 15 wt.%, indicating successful impregnation. According to the nitrogen sorption–desorption results, the specific surface area of the purified diatomite particles (<63 μm) increased from 26.47 to 46.33 m2g–1compared to crude diatomite. The 15Ni/Ds-700 catalyst was applied in the dry reforming of methane to obtain synthesis gas (CO and H2). The results showed that the catalyst was relatively stable during catalytic measurements for 6 h, although the conversion rate value was low (12%).
A guidance for the enrichment of micropollutants from wastewater by solid-phase extraction before bioanalytical assessment
Authors: Schulze Tobias , Neale Peta A. , Ahlheim Jörg , Beckers Liza-Marie , König Maria , Krüger Janet , Petre Margit , Piotrowska Aleksandra , Schlichting Rita , Schmidt Susanne , Krauss Martin , Escher Beate I. 
Published: September 2024

Abstract
Background
Wastewater can contain a complex mixture of organic micropollutants, with both chemical analysis and effect-based methods needed to identify relevant micropollutants and detect mixture effects. Solid-phase extraction (SPE) is commonly used to enrich micropollutants prior to analysis. While the recovery and stability of individual micropollutants by SPE has been well studied, few studies have optimized SPE for effect-based methods. The aim of the current study was to develop and evaluate two standard operating procedures (SOPs) for the enrichment of micropollutants in preparation for chemical analysis and bioanalysis, one covering a broad range of chemicals and the other selective for estrogenic chemicals.

Results
Pristine surface water spiked with > 600 micropollutants was used to develop a generic extraction method for micropollutants with a wide range of physiochemical properties, while water spiked with estrogenic chemicals was used to identify a selective extraction method. Three different SPE sorbents were tested, with recoveries of individual chemicals and effect in assays indicative of mutagenicity, estrogenic activity, and fish embryo toxicity assessed. The sorbent HRX at pH 7 was selected for the generic extraction method as it showed the best recovery of both individual chemicals and effect in the bioassays. The sorbent HLB at pH 3 showed optimal recovery of estrogenic chemicals and estrogenic activity. The two optimal SPE methods were applied to spiked and unspiked wastewater effluents, with the concentrations of detected chemicals and observed effects similar to those of previous studies. The long-term storage of both extracts and SPE cartridges for estrogens and estrogenic activity after extraction with the HRX and HLB methods were evaluated, with estrogenic effectiveness close to 100% after 112 days when HLB was used.

Conclusions
HRX is recommended for generic extraction, while HLB is optimal for the selective extraction of estrogenic micropollutants. However, if a laboratory only wants to use a single SPE sorbent, HLB can be used for both generic and selective extraction as it yielded similar chemical and effect recovery as HRX for a wide range of micropollutants. This paper is supplemented by the final SOP that includes a variant for generic extraction and one for the extraction of estrogenic chemicals.
3D genome contributes to MHC-II neoantigen prediction
Authors: Feng Mofan , Liu Liangjie , Su Kai , Su Xianbin , Meng Luming , Guo Zehua , Cao Dan , Wang Jiayi , He Guang , Shi Yi 
Published: September 2024

AbstractReliable and ultra-fast DNA and RNA sequencing have been achieved with the emergence of high-throughput sequencing technology. When combining the results of DNA and RNA sequencing for tumor cells of cancer patients, neoantigens that potentially stimulate the immune response of either CD4+ or CD8+ T cells can be identified. However, due to the abundance of somatic mutations and the high polymorphic nature of human leukocyte antigen (HLA) it is challenging to accurately predict the neoantigens. Moreover, comparing to HLA-I presented peptides, the HLA-II presented peptides are more variable in length, making the prediction of HLA-II loaded neoantigens even harder. A number of computational approaches have been proposed to address this issue but none of them considers the DNA origin of the neoantigens from the perspective of 3D genome. Here we investigate the DNA origins of the immune-positive and non-negative HLA-II neoantigens in the context of 3D genome and discovered that the chromatin 3D architecture plays an important role in more effective HLA-II neoantigen prediction. We believe that the 3D genome information will help to increase the precision of HLA-II neoantigen discovery and eventually benefit precision and personalized medicine in cancer immunotherapy.
Evaluating the accuracy and reliability of AI chatbots in disseminating the content of current resuscitation guidelines: a comparative analysis between the ERC 2021 guidelines and both ChatGPTs 3.5 and 4
Authors: Beck Stefanie , Kuhner Manuel , Haar Markus , Daubmann Anne , Semmann Martin , Kluge Stefan 
Published: September 2024

Abstract
Aim of the study
Artificial intelligence (AI) chatbots are established as tools for answering medical questions worldwide. Healthcare trainees are increasingly using this cutting-edge technology, although its reliability and accuracy in the context of healthcare remain uncertain. This study evaluated the suitability of Chat-GPT versions 3.5 and 4 for healthcare professionals seeking up-to-date evidence and recommendations for resuscitation by comparing the key messages of the resuscitation guidelines, which methodically set the gold standard of current evidence and recommendations, with the statements of the AI chatbots on this topic.

Methods
This prospective comparative content analysis was conducted between the 2021 European Resuscitation Council (ERC) guidelines and the responses of two freely available ChatGPT versions (ChatGPT-3.5 and the Bing version of the ChatGPT-4) to questions about the key messages of clinically relevant ERC guideline chapters for adults. (1) The content analysis was performed bidirectionally by independent raters. The completeness and actuality of the AI output were assessed by comparing the key message with the AI-generated statements. (2) The conformity of the AI output was evaluated by comparing the statements of the two ChatGPT versions with the content of the ERC guidelines.

Results
In response to inquiries about the five chapters, ChatGPT-3.5 generated a total of 60 statements, whereas ChatGPT-4 produced 32 statements. ChatGPT-3.5 did not address 123 key messages, and ChatGPT-4 did not address 132 of the 172 key messages of the ERC guideline chapters. A total of 77% of the ChatGPT-3.5 statements and 84% of the ChatGPT-4 statements were fully in line with the ERC guidelines. The main reason for nonconformity was superficial and incorrect AI statements. The interrater reliability between the two raters, measured by Cohen’s kappa, was greater for ChatGPT-4 (0.56 for completeness and 0.76 for conformity analysis) than for ChatGPT-3.5 (0.48 for completeness and 0.36 for conformity).

Conclusion
We advise healthcare professionals not to rely solely on the tested AI-based chatbots to keep up to date with the latest evidence, as the relevant texts for the task were not part of the training texts of the underlying LLMs, and the lack of conceptual understanding of AI carries a high risk of spreading misconceptions. Original publications should always be considered for comprehensive understanding.
Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats
Authors: Gobbi Carlotta , Sánchez-Marín Laura , Flores-López María , Medina-Vera Dina , Pavón-Morón Francisco Javier , Rodríguez de Fonseca Fernando , Serrano Antonia 
Published: September 2024

Abstract
Background
Adolescent stress and alcohol exposure increase the risk of maladaptive behaviors and mental disorders in adulthood, with distinct sex-specific differences. Understanding the mechanisms underlying these early events is crucial for developing targeted prevention and treatment strategies.

Methods
Male and female Wistar rats were exposed to acute restraint stress and intermittent alcohol during adolescence. We assessed lasting effects on plasma corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels, and mRNA expression of genes related to corticotropin releasing hormone (CRH), neuropeptide Y (NPY), corticoid, opioid, and arginine vasopressin systems in the amygdala and hypothalamus.

Results
The main findings are as follows: (1) blood alcohol concentrations (BAC) increased after the final alcohol administration, but stressed males had lower BAC than non-stressed males; (2) Males gained significantly more weight than females; (3) Stressed females showed higher ACTH levels than non-stressed females, with no changes in males; (4) Stress increased CORT levels in males, while stressed, alcohol-treated females had lower CORT levels than non-stressed females; (5) CRH: Females had lower Crhr1 levels in the amygdala, while alcohol reduced Crhr2 levels in males but not females. Significant interactions among sex, stress, and alcohol were found in the hypothalamus, with distinct patterns between sexes; (6) NPY: In the amygdala, stress reduced Npy and Npy1r levels in males but increased them in females. Alcohol decreased Npy2r levels in males, with varied effects in females. Similar sex-specific patterns were observed in the hypothalamus; (7) Corticoid system: Stress and alcohol had complex, sex-dependent effects on Pomc, Nr3c1, and Nr3c2 in both brain regions; (8) Opioid receptors: Stress and alcohol blunted the elevated expression of Oprm1, Oprd1, and Oprk1 in the amygdala of males and the hypothalamus of females; (8) Vasopressin: Stress and alcohol interacted significantly to affect Avp and Avpr1a expression in the amygdala, with stronger effects in females. In the hypothalamus, alcohol increased Avp levels in females.

Conclusions
This study demonstrates that adolescent acute stress and alcohol exposure induce lasting, sex-specific alterations in systems involved in reward and stress responses. These findings emphasize the importance of considering sex differences in the prevention and management of HPA dysfunction and psychiatric disorders.
Volume, increment, and aboveground biomass data series and biomass conversion and expansion factors for the main forest types of EU Member States
Authors: Pilli Roberto , Blujdea Viorel N.B. , Rougieux Paul , Grassi Giacomo , Mubareka Sarah Betoul 
Published: September 2024

Abstract
Key message
This collection reports the standing stock volume, increment, aboveground biomass, and biomass conversion and expansion factors attributed to 222 forest types and 48 different management types, representative of 25 EU Member States. DOI: https://zenodo.org/records/11387301.