bluuebunny/crossref_metadata_2025_split huggingface dataset:
Air‐Stable, Near‐ to Mid‐Infrared Emitting Solids of PbTe/CdTe Core–Shell Colloidal quantum dots
Authors: Protesescu Loredana , Zünd Tanja , Bodnarchuk Maryna I. , Kovalenko Maksym V. 
Published: December 2015

AbstractLight emitters and detectors operating in the near‐ and mid‐infrared spectral regions are important to many applications, such as telecommunications, high‐resolution gas analysis, atmospheric pollution monitoring, medical diagnostics, and night vision. Various lead chalcogenides (binary, ternary, and quaternary alloys) in the form of quantum dots (QDs) or quantum wells provide narrow bandgap energies that cover the broad infrared region corresponding to wavelengths of 1–30 μm. Here, we report an inexpensive, all‐solution‐based synthesis strategy to thin‐film solids consisting of 5‐16 nm PbTe QDs encapsulated by CdTe shells. Colloidally synthesized PbTe QDs were first converted into core–shell PbTe/CdTe QDs, and then deposited as thin films. The subsequent fusion of the CdTe shells is achieved by ligand removal and annealing in the presence of CdCl2. Contrary to highly unstable bare PbTe QDs, PbTe/CdTe QD solids exhibit bright and stable near‐ to mid‐infrared emission at wavelengths of 1–3 μm, which is also retained upon prolonged storage at ambient conditions for one year.
Tuning of the HOMO–LUMO Gap of Symmetrical and Unsymmetrical Ferrocenyl‐Substituted Diketopyrrolopyrroles
Authors: Patil Yuvraj , Jadhav Thaksen , Dhokale Bhausaheb , Misra Rajneesh 
Published: December 2015

AbstractFerrocenyl‐substituted diketopyrrolopyrroles (DPPs) with the symmetrical π‐bridged donor–acceptor (D–π–A) frameworks D′–π–D–A–D–π–D′ and D′–A′–D–A–D–A′–D′ as well as unsymmetrical D–A–D–π–D′ and D–A–D–A′–D′ frameworks were designed and synthesized by a Pd‐catalyzed Sonogashira cross‐coupling reaction followed by a [2+2] cycloaddition–retroelectrocyclization reaction. The tetracyanobutadiene (TCBD) DPPs 7 and 8 have redshifted absorption bands and lower HOMO–LUMO gap values relative to those of ferrocenyl‐DPPs 5 and 6. The electronic absorption spectra show a systematic redshift in the intramolecular charge transfer (ICT) band from the ferrocene to the diketopyrrolopyrrole core. The photophysical, computational, and electrochemical properties were also investigated and show substantial donor–acceptor interactions between the ferrocene and DPP moieties. The symmetrical ferrocenyl‐DPPs have more thermal stability than the unsymmetrical derivatives.
Effects of norepinephrine transporter gene variants on NET binding in ADHD and healthy controls investigated by PET
Authors: Sigurdardottir Helen L. , Kranz Georg S. , Rami‐Mark Christina , James Gregory M. , Vanicek Thomas , Gryglewski Gregor , Kautzky Alexander , Hienert Marius , Traub‐Weidinger Tatjana , Mitterhauser Markus , Wadsak Wolfgang , Hacker Marcus , Rujescu Dan , Kasper Siegfried , Lanzenberger Rupert 
Published: December 2015

AbstractAttention deficit hyperactivity disorder (ADHD) is a heterogeneous disorder with a strong genetic component. The norepinephrine transporter (NET) is a key target for ADHD treatment and the NET gene has been of high interest as a possible modulator of ADHD pathophysiology. Therefore, we conducted an imaging genetics study to examine possible effects of single nucleotide polymorphisms (SNPs) within the NET gene on NET nondisplaceable binding potential (BPND) in patients with ADHD and healthy controls (HCs). Twenty adult patients with ADHD and 20 HCs underwent (S,S)‐[18F]FMeNER‐D2 positron emission tomography (PET) and were genotyped on a MassARRAY MALDI‐TOF platform using the Sequenom iPLEX assay. Linear mixed models analyses revealed a genotype‐dependent difference in NET BPND between groups in the thalamus and cerebellum. In the thalamus, a functional promoter SNP (−3081 A/T) and a 5′‐untranslated region (5′UTR) SNP (−182 T/C), showed higher binding in ADHD patients compared to HCs depending on the major allele. Furthermore, we detected an effect of genotype in HCs, with major allele carriers having lower binding. In contrast, for two 3′UTR SNPs (*269 T/C, *417 A/T), ADHD subjects had lower binding in the cerebellum compared to HCs depending on the major allele. Additionally, symptoms of hyperactivity and impulsivity correlated with NET BPND in the cerebellum depending on genotype. Symptoms correlated positively with cerebellar NET BPND for the major allele, while symptoms correlated negatively to NET BPND in minor allele carriers. Our findings support the role of genetic influence of the NE system on NET binding to be pertubated in ADHD. Hum Brain Mapp 37:884–895, 2016. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
Phasic and sustained brain responses in the amygdala and the bed nucleus of the stria terminalis during threat anticipation
Authors: Herrmann Martin J. , Boehme Stephanie , Becker Michael P.I. , Tupak Sara V. , Guhn Anne , Schmidt Brigitte , Brinkmann Leonie , Straube Thomas 
Published: December 2015

AbstractSeveral lines of evidence suggest that the amygdala and the bed nucleus of the stria terminalis (BNST) are differentially involved in phasic and sustained fear. Even though, results from neuroimaging studies support this distinction, a specific effect of a temporal dissociation with phasic responses to onset versus sustained responses during prolonged states of threat anticipation has not been shown yet. To explore this issue, we investigated brain activation during anticipation of threat in 38 healthy participants by means of functional magnetic resonance imaging. Participants were presented different visual cues indicated the temporally unpredictable occurrence of a subsequent aversive or neutral stimulus. During the onset of aversive versus neutral anticipatory cues, results showed a differential phasic activation of amygdala, anterior cingulate cortex (ACC), and ventrolateral prefrontal cortex (PFC). In contrast, activation in the BNST and other brain regions, including insula, dorsolateral PFC, ACC, cuneus, posterior cingulate cortex, and periaqueductal grey was characterized by a sustained response during the threat versus neutral anticipation period. Analyses of functional connectivity showed phasic amygdala response as positively associated with activation, mainly in sensory cortex areas whereas sustained BNST activation was negatively associated with activation in visual cortex and positively correlated with activation in the insula and thalamus. These findings suggest that the amygdala is responsive to the onset of cues signaling the unpredictable occurrence of a potential threat while the BNST in concert with other areas is involved in sustained anxiety. Furthermore, the amygdala and BNST are characterized by distinctive connectivity patterns during threat anticipation. Hum Brain Mapp 37:1091–1102, 2016. © 2015 Wiley Periodicals, Inc.
In vivo MRI signatures of hippocampal subfield pathology in intractable epilepsy
Authors: Goubran Maged , Bernhardt Boris C. , Cantor‐Rivera Diego , Lau Jonathan C. , Blinston Charlotte , Hammond Robert R. , de Ribaupierre Sandrine , Burneo Jorge G. , Mirsattari Seyed M. , Steven David A. , Parrent Andrew G. , Bernasconi Andrea , Bernasconi Neda , Peters Terry M. , Khan Ali R. 
Published: December 2015

AbstractObjectivesOur aim is to assess the subfield‐specific histopathological correlates of hippocampal volume and intensity changes (T1, T2) as well as diff!usion MRI markers in TLE, and investigate the efficacy of quantitative MRI measures in predicting histopathology in vivo.Experimental DesignWe correlated in vivo volumetry, T2 signal, quantitative T1 mapping, as well as diffusion MRI parameters with histological features of hippocampal sclerosis in a subfield‐specific manner. We made use of on an advanced co‐registration pipeline that provided a seamless integration of preoperative 3 T MRI with postoperative histopathological data, on which metrics of cell loss and gliosis were quantitatively assessed in CA1, CA2/3, and CA4/DG.Principal ObservationsMRI volumes across all subfields were positively correlated with neuronal density and size. Higher T2 intensity related to increased GFAP fraction in CA1, while quantitative T1 and diffusion MRI parameters showed negative correlations with neuronal density in CA4 and DG. Multiple linear regression analysis revealed that in vivo multiparametric MRI can predict neuronal loss in all the analyzed subfields with up to 90% accuracy.ConclusionOur results, based on an accurate co‐registration pipeline and a subfield‐specific analysis of MRI and histology, demonstrate the potential of MRI volumetry, diffusion, and quantitative T1 as accurate in vivo biomarkers of hippocampal pathology. Hum Brain Mapp 37:1103–1119, 2016. © 2015 Wiley Periodicals, Inc.
External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma
Authors: Terra Ximena , Gómez David , García‐Lorenzo Jacinto , Flores Joan Carles , Figuerola Enric , Mora Josefina , Chacón Matilde R. , Quer Miquel , Camacho Mercedes , León Xavier , Avilés–Jurado Francesc Xavier 
Published: December 2015

AbstractBackgroundThe main purpose of this study was to validate the prognostic significance of tumor necrosis factor (TNF)‐like weak inducer of apoptosis (TWEAK) in head and neck squamous cell carcinoma (HNSCC) using an independent cohort.MethodsData were evaluated from 153 patients with HNSCC in stages III to IV, who received radiotherapy (RT) or chemoradiotherapy. We quantified soluble TWEAK (sTWEAK) in pretreatment samples using enzyme‐linked immunosorbent assay.ResultsThe classification tree revealed a cutoff value of 322 pg/mL for sTWEAK to be ideal for discriminating between patients' disease control. Kaplan–Meier curves indicate that the disease‐free survival rate in patients with high sTWEAK was significantly higher than in patients with low levels (p = .006, log‐rank test). An independent link was identified between low sTWEAK and poor clinical outcome in Cox regression multivariate analysis (hazard ratio = 1.866; 95% confidence interval [CI] = 1.114–3.125; p = .001).ConclusionOur study highlights the significance of this noninvasive biomarker in the discrimination according to the disease control achieved by patients who received a nonsurgical organ‐preservation treatment. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1358–E1363, 2016
Bone‐impacted fibular free flap: Long‐term dental implant success and complications compared to traditional fibular free tissue transfer
Authors: Barber Brittany R. , Dziegelewski Peter T. , Chuka Richelle , O'Connell Daniel , Harris Jeffrey R. , Seikaly Hadi 
Published: December 2015

AbstractBackgroundThe purpose of this study was to compare complications and dental implant success between the bone‐impacted fibula free flap (BIFFF) and the traditional fibular free flap used in mandibular and midface reconstruction.MethodsRetrospective review of all patients undergoing BIFFF or traditional fibular free flap reconstruction from 2001 to 2009 was undertaken. Complications related to the BIFFF and traditional fibular free flap site of reconstruction were compared. Dental implant success rates for each type of flap were compared at 1‐year intervals for 5 years.ResultsOne hundred fourteen patients underwent 81 BIFFFs and 35 traditional fibular free flaps. No significant difference in complications between BIFFF (20.9%) and traditional fibular free flap (25.7%) reconstruction was observed. Logistic regression analysis revealed only the site as a predictor of both single and multiple complications. At 5 years postimplantation, dental implant success rates were 95.5% and 77.1% for BIFFF and traditional fibular free flap, respectively (p = .006).ConclusionBIFFF reconstruction is a novel surgical technique that may improve long‐term dental implant success rates with no additional risk of complications. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1783–E1787, 2016
Dissolved inorganic carbon evolution in neutral discharge from mine tailings piles
Authors: Ali Hendratta N. , Atekwana Eliot A. 
Published: December 2015

AbstractWe measured the concentrations of dissolved inorganic carbon (DIC) and major ions and the stable carbon isotope ratios of DIC (δ13CDIC) in two creeks discharging from carbonate‐rich sulphide‐containing mine tailings piles. Our aim was to assess downstream carbon evolution of the tailings discharge as it interacted with the atmosphere. The discharge had pH of 6.5–8.1 and was saturated with respect to carbonates. Over the reach of one creek, the DIC concentrations decreased by 1.1 mmol C/l and δ13CDIC increased by ~4.0‰ 200 m from the seep source. The decrease in the DIC concentrations was concomitant with decreases in the partial pressure of CO2(aq) because of the loss of excess CO2(aq) from the discharge. The corresponding enrichment in the δ13CDIC is because of kinetic isotope fractionation accompanying the loss of CO2(g). Over the reach of the other creek, there was no significant decrease in the DIC concentrations or notable changes in the δ13CDIC. The insignificant change in the DIC concentrations and the δ13CDIC is because the first water sample was collected 160 m away from the discharge seep, not accessible during this research. In this case, most of the excess CO2(aq) was lost before our first sampling station. Our results indicate that neutral discharges from tailings piles quickly lose excess CO2(aq) to the atmosphere and the DIC becomes enrich in 13C. We suggest that a significant amount of carbon cycling in neutral discharges from tailings piles occur close to the locations where the discharge seeps to the surface. Copyright © 2015 John Wiley & Sons, Ltd.
Complexation versus Hemodialysis To Reduce Elevated Aminoglycoside Serum Concentrations
Authors: Schentag Jerome J. , Simons Gary W. , Schultz Robert W. , Vance John W. , Williams James S. 
Published: December 2015

Seven patients with acutely elevated aminoglycoside serum concentrations were studied comparing the effect of hemodialysis (n = 3) with removal by complexation using ticarcillin or carbenicillin (n = 4). Aminoglycoside serum half‐life before intervention averaged 96 hours for the dialysis group and 67 hours for the complexation group. Ticarcillin was used for a minimum of 48 hours, while hemodialysis removal was estimated over 48 hours, which included two 4‐hour dialysis periods. Aminoglycoside serum half‐life was reduced to an average of 11 hours with hemodialysis, while with complexation using ticarcillin, it was reduced to 12 hours.During the 48‐hour comparison period, complexation removed approximately 50% more aminoglycoside than did hemodialysis, primarily because the improved removal technique was sustained over the entire time. Complexation appears to be as effective as continuous hemodialysis in lowering excessive aminoglycoside serum concentrations. Complexation with ticarcillin can be more rapidly initiated, is less expensive and there is a low risk of adverse reactions. This method provides continued treatment of infections in patients with elevated serum concentrations and/or nephrotoxicity who require cessation of aminoglycoside therapy.
Daily and Alternate‐day Treatment with an LHRH Analog in the Therapy of Idiopathic Hypogonadotropic Hypogonadism
Authors: LOMBARDI G. , DE ROSA M. , TORINO G. , QUAGLIOZZI L. , AURIGEMMA A. C. , PANZA N. 
Published: December 2015

Twenty‐five male patients with idiopathic hypogonadotropic hypogonadism were treated with 5μg of an LHRH analog (D‐Leu6‐Des‐Gly10‐LHRH‐ethylamide) intramuscularly for one month. The FSH and LH responses (quantitated as cumulative response areas) to acute LHRH intravenous administration (100 μg) were evaluated before and after each week of treatment. The patients were randomly divided into two groups: group A (16 patients) was treated every day; group B (nine patients) was treated every other day. Each group was divided into two subgroups (1 and 2), according to the degree of pretreatment LH response impairment. Patients in the first subgroup had a pretreatment cumulative response area greater than 3 SD below the mean for normal males. Patients in the second subgroup had a response less than 3 SD below the mean for normal males.Daily treatment produced a significant and progressive increase in LH response in subgroup A‐1, but in the second subgroup (A‐2) there was a maximal increase after the first and second week, with a subsequent decline. Alternate‐day treatment, on the other hand, produced a significant and progressive increase in LH response in all patients from subgroups B‐1 and B‐2.Both daily and alternate‐day treatments induced an initial increase in FSH response during the first week, followed by a progressive decline in all the groups. Finally, there was a lack of response to either form of treatment with regard to testosterone secretion and spermatogenesis.The findings indicate that LH response to LHRH analog differed depending on the degree of pretreatment pituitary impairment and the course of therapy followed.
The Regulation of the Proliferation and Differentiation of Rat Leydig Cell Precursor Cells After EDS Administration or Daily HCG Treatment
Authors: TEERDS KATJA J. , de ROOIJ DIRK G. , ROMMERTS FOCKO F. G. , WENSING CEES J. G. 
Published: December 2015

The proliferation and differentiation of possible Leydig cell precursors in adult rats were studied after destruction of the existing Leydig cells with EDS or after daily treatment with hCG. After 2 days with either treatment, a 12‐ to 16‐fold increase in the number of [3H]thymidine‐incorporating interstitial cells was found. In the case of hCG treatment, this was probably due to the high plasma hCG levels. However, after EDS treatment, LH levels start to rise between days 1 and 3, suggesting a paracrine stimulation of the proliferation of interstitial cells.After hCG treatment, a substantial increase in the numbers of Leydig cells was already found at day 2. It was concluded that hCG induced a rapid differentiation, without cell division, of existing precursor cells into recognizable Leydig cells. In rats treated with both EDS and hCG, new Leydig cells were not formed during the first 10 days. This indicates that EDS destroys not only mature Leydig cells but also those Leydig cell precursors that are able to differentiate rapidly into recognizable Leydig cells.
Autoantibody Profile of Adult Patients With Childhood Onset Type 2 Autoimmune Hepatitis
Authors: Woynarowski Marek , Woźniak Małgorzata , Cukrowska Bożena , Wierzbicka Aldona , Lytton Simon D. 
Published: December 2015

BackgroundAnti‐liver kidney microsome (anti‐LKM) autoantibodies are a distinguishing feature of type II autoimmune hepatitis (AIH‐2). However, the levels of anti‐LKM‐1 in adult AIH‐2 patients and their role in liver immunopathology remain equivocal. The aim of the study was to survey the autoantibody profile and the activity of liver disease in adult patients diagnosed with AIH‐2 at childhood.MethodsThe autoantibody profile of adults was compared with the autoantibodies of the pediatric period. Liver function test, Immunoglobulin G (IgG), and gamma globulins were evaluated at the AIH presentation, at the age of 18 years, and at the current adult visit.ResultsAll ten patients tested positive for LKM‐1 at least once during the pediatric period. At the adult visit, four patients lost autoantibody positivity. LKM‐1 was positive in four, liver cytosol antigen 1 (LC‐1) in two, soluble liver antigen in one, and antinuclear antigen in one patient. Additionally three patients with LKM‐1 and one patient without LKM‐1 were positive for AMA‐M2 (where AMA is antimitochondrial antibodies) Immunoglobulin M (IgM). Liver function markedly improved at 18 years and adult visit compared with initial diagnosis of AIH with only a mild decrease of IgG. The six adult patients positive for at least one autoantibody had statistically lower aspartate aminotransferase (AST) and gamma‐glutamyltranspeptidase (GGTP) than the four patients autoantibody negative (AST: 52 vs. 88 IU/l, P < 0.05; GGTP 19 vs. 163 IU/l, P < 0.05).ConclusionLKM‐1 positivity is not a stable condition in all patients with AIH‐2. Patients who remained autoantibody positive had better liver function tests than those who lost their positivity. The presence of AMA‐M2 autoantibodies suggest that development of AIH/Primary Biliary Cirrhosis (PBC) overlap syndrome should be considered.
Location and functional characterization of the right atrioventricular pacemaker ring in the adult avian heart
Authors: Prosheva Valentina I. , Kaseva Natalya N. 
Published: December 2015

ABSTRACTPrevious histological studies showed that in addition to a sinus node, an atrioventricular (AV) node, an AV bundle, left and right bundle branches, birds also possess a right AV‐Purkinje ring that is located in the atrial sheet of the right muscular AV‐valve along all its base length. The functionality of the AV‐Purkinje ring is unknown. In this work, we studied the topology of pacemaker myocytes in the atrial side of the isolated chicken spontaneously contracting right muscular AV‐valve using the method of microelectrode mapping of action potentials. We show that AV‐cells having the ability to show pacemaking reside in the right muscular AV‐valve. Pacemaker action potentials were exclusively recorded close to the base of the valve along its whole length from dorsal to the ventral attachment to the interventricular septum. These action potentials have much slower rate of depolarization, lower amplitude, and higher diastolic depolarization than action potentials of Purkinje (conducting) cells. We conclude the right AV‐valve has a ring bundle of pacemaker cells (but not Purkinje cells) in the adult chicken heart. J. Morphol. 277:363–369, 2016. © 2015 Wiley Periodicals, Inc.
Serum metabolomics analysis of rat after intragastric infusion of Pu‐erh theabrownin
Authors: Liu Jian , Peng Chun‐xiu , Gao Bin , Gong Jia‐shun 
Published: December 2015

AbstractBACKGROUNDThe aim was to study the effects of Pu‐erh theabrownin (TB) (Mw > 50 kDa) on the metabolism of rat serum by nuclear magnetic resonance (NMR)‐based metabolomics and identify candidate marker metabolites associated with Pu‐erh TB, and thus provide fundamental information for a better understanding of the metabolism of Pu‐erh tea in animals.RESULTSTB infusion induced different changes in endogenous serum metabolites depending on the type of diet. Compared with the control group, the TB infusion group showed significantly reduced serum glycine and choline levels, as well as significantly increased taurine, carnitine and high‐density lipoprotein (all P < 0.05). Compared with the high‐lipid group, the high‐lipid TB infusion group exhibited significantly reduced low‐density lipoprotein and acetate levels, as well as significantly increased inositol, carnitine and glycine levels (all P < 0.05).CONCLUSIONExamination of the variations of these differential expressed metabolites and their individual functions revealed that the TB extract accelerated lipid catabolism in rats and might affect glucose metabolism. Of these, carnitine level significantly increased after intragastric infusion of TB regardless of the type of diet, and activities of carnitine palmitoyltransferases I and II changed significantly, suggesting carnitine may be a candidate serum marker for tracking the metabolism of TB in rats. © 2015 Society of Chemical Industry