bluuebunny/crossref_metadata_2025_split huggingface dataset:
FLUORO/NO: A Nitric Oxide Donor with a Fluorescence Reporter
Authors: Ravikumar Govindan , Bagheri Meisam , Saini Deepak Kumar , Chakrapani Harinath 
Published: May 2017

AbstractNitric oxide (NO) plays significant signalling roles in cells; the controlled generation of NO is of therapeutic relevance. Although a number of methods for the delivery and detection of NO are available, these events are typically mutually exclusive. Furthermore, the efficiency of delivery of NO can be compromised by detection technologies that consume NO. Here, we report FLUORO/NO, an esterase‐activated diazeniumdiolate‐based NO donor with an in‐built fluorescence reporter. We demonstrate that this compound is capable of enhancing NO within cells in a dose‐dependent manner, accompanied by a similar increase in fluorescence. The compatibility of this tool to study NO‐mediated signalling as well as NO‐mediated stress is demonstrated. FLUORO/NO is a convenient tool that shows NO‐like activity and allows monitoring of NO release. This tool will help interrogate the redox biology of NO.
Patient preference for radial versus femoral vascular access for elective coronary procedures: The PREVAS study
Authors: Kok Marlies M. , Weernink Marieke G.M. , von Birgelen Clemens , Fens Anneloes , van der Heijden Liefke C. , van Til Janine A. 
Published: May 2017

ObjectivesTo explore patient preference for vascular access site in percutaneous coronary procedures, the perceived importance of benefits and risks of transradial access (TRA) and transfemoral access (TFA) were assessed. In addition, direct preference for vascular access and preference for shared decision making (SDM) were evaluated.BackgroundTRA has gained significant ground on TFA during the last decades. Surveys on patient preference have mostly been performed in dedicated TRA trials.MethodsIn the PREVAS study (Clinicaltrials.gov: NCT02625493) a stated preference elicitation method best‐worst scaling (BWS) was used to determine patient preference for six treatment attributes: bleeding, switch of access‐site, postprocedural vessel quality, mobilization and comfort, and over‐night stay. Based on software‐generated treatment scenarios, 142 patients indicated which characteristics they perceived most and least important in treatment choice. Best‐minus‐Worst scores and attribute importance were calculated.ResultsBleeding risk was considered most important (attribute importance 31.3%), followed by length of hospitalization (22.6%), and mobilization(20.2%). Most patients preferred the approach of their current procedure (85.9%); however, 71.1% of patients with experience with both access routes favored TRA (P < 0.001). Most patients (38.0%) appreciated SDM, balanced between patient and cardiologist.ConclusionsPatients appreciate lower bleeding risk and early ambulation, factors favoring TRA. Previous experience with a single access route has a major impact on preference, while experience with both routes generally resulted in preference for TRA. Most patients prefer balanced SDM. © 2017 The Authors Catheterization and Cardiovascular Interventions Published by Wiley Periodicals, Inc.
SUPERB final 3‐year outcomes using interwoven nitinol biomimetic supera stent
Authors: Garcia Lawrence A. , Rosenfield Kenneth R. , Metzger Christopher D. , Zidar Frank , Pershad Ashish , Popma Jeffrey J. , Zaugg Margo , Jaff Michael R. ,   on behalf of the SUPERB investigators
Published: May 2017

ImportanceLong‐term outcomes of an interwoven nitinol stent design represent the best in class for treatment of lower limb arterial obstructive diseaseMethodsThe subjects were enrolled in an open single arm study comparing the outcomes to an FDA mandated objective performance goal (OPG).ResultsAbout 325 patients (264 intention‐to‐treat and 64 roll‐in subjects) were enrolled. Mean follow‐up period was 887+/– 352 days. Treated lesion lengths were 7.8 cm ± 4.3 cm in the trial with chronic total occlusions comprising 24.6% (65/264) of subjects. Freedom from clinically driven target lesion revascularization (CD‐TLR) at 12 months was 89%, at 24 and 36 months it was 84% and 82% respectively. The difference in the 12 month CD‐TLR was 7% at 36 months. The difference of clinically driven‐TLR at 36 months in those subjects who received their stents deployed nominally in length, compressed or elongated (between −10% and +10% nominal length) had an impact on the CD‐TLR. At 2 and 3 years, freedom from CD‐TLR in minimal compression was 86.7%, and was 90.0% for moderate compression. In those stents deployed with minimal, moderate, or severe elongation (10–20%, 20–40%, or >40%, respectively) freedom from CD‐TLR of 84.1%, 87.4%, and 77.0% respectively at 12 months. At 2 and 3 years, freedom from CD‐TLR for moderate elongation was 81.8% and 78.2%, and for severe elongation was 63.4% and 42.3%, respectively. Fractures were distinctly uncommon with this stent with a single facture event in the 36 month follow‐up period.DiscussionThe interwoven nitinol design stent is a stent that achieves an excellent primary patency but further maintains the durability of the stent through 36 months. Optimal stent deployment remains critical to the performance of this stent device and requires optimal vessel preparation. © 2017 Wiley Periodicals, Inc.
The prognostic importance of the diastolic pulmonary gradient, transpulmonary gradient, and pulmonary vascular resistance in patients undergoing transcatheter aortic valve replacement
Authors: Brunner Nathan W. , Yue Su Fei , Stub Dion , Ye Jian , Cheung Anson , Leipsic Jonathon , Lauck Sandra , Dvir Danny , Perlman Gidon , Htun Nay , Fahmy Peter , Prakash Roshan , Eng Lim , Ong Kevin , Tsang Michael , Cairns John A. , Webb John G. , Wood David A. 
Published: May 2017

ObjectivesTo evaluate the association between markers of precapillary pulmonary hypertension (PH) and survival in transcatheter aortic valve replacement (TAVR).BackgroundThe importance of precapillary PH has been sparsely investigated in patients undergoing TAVR. It may prove an important risk factor for poor outcomes.MethodsWe identified patients at our institution undergoing TAVR with a baseline right heart catheterization (RHC) demonstrating PH. We evaluated the association between markers of precapillary PH and survival including the diastolic pulmonary gradient (DPG), transpulmonary gradient (TPG), and pulmonary vascular resistance (PVR). A multivariable analysis was performed using Cox Proportional Hazards Models, adjusting for age, gender, body mass index, and pulmonary artery systolic pressure (PASP) on echocardiography.ResultsWe identified 133 patients with PH on RHC. Of these 111 had low DPG and 22 had high DPG. All 3 markers of precapillary PH were associated with worse survival post TAVR, with OR of 2.1 (95% CI 1.1–3.9, P = 0.02), 3.4 (95% CI 1.8–6.4, P < 0.001) and 2.5 (95% CI 1.4–4.5, P = 0.003) for high DPG, TPG, and PVR, respectively. On multivariable analysis, both TPG and PVR remained predictors of worse survival, with OR of 3.4 (95% CI 1.7–6.9, P = 0.001) and 2.5 (95% CI 1.4–4.5, P = 0.003). Echocardiographic PASP and DPG were not predictive of survival.ConclusionsIn patients undergoing TAVR, parameters of precapillary PH are associated with lower survival, and provide incremental prognostication over echocardiographic PASP. RHC should continue to play an important role in risk stratification prior to TAVR. © 2017 Wiley Periodicals, Inc.
Impact of small prosthesis size on transcatheter or surgical aortic valve replacement outcomes
Authors: Salna Michael , Khalique Omar K. , Chiuzan Codruta , Kurlansky Paul , Borger Michael A. , Hahn Rebecca T. , Leon Martin B. , Smith Craig R. , Kodali Susheel K. , George Isaac 
Published: May 2017

ObjectivesDetermine the comparative impact of small prosthesis size on transcatheter and surgical aortic valve replacement (SAVR) outcomes.BackgroundPatients with small aortic annuli tend to have worse postoperative outcomes and hemodynamics. We sought to describe surgical outcomes in patients with very small aortic annuli and then compare early hemodynamic and clinical outcomes in patients undergoing surgical or transcatheter aortic valve replacement (TAVR) with the smallest available valves to assist in optimal prosthesis selection for this challenging patient population.MethodsA retrospective single‐center study comparing patient data from 2143 patients undergoing SAVR with valves having a true internal diameter (ID) of ≥19 mm with 130 patients receiving surgical valves with true ID's <19 mm (SmSAVR). Outcomes of SmSAVR patients were then compared with 40 patients undergoing TAVR receiving small valves (SmTAVR). A representative SmSAVR cohort was then compared with the SmTAVR patients for post‐operative hemodynamics.ResultsReceiving a small surgical valve may significantly increase 1‐year mortality compared with standard‐sized surgical valves (HR 1.93; 95% confidence interval 1.03–3.61). SmTAVR patients had significantly shorter lengths of stay than SmSAVR (median 5 vs. 9 days), and significantly better postoperative hemodynamic profiles (mean gradient 13.4 ± 7.8 vs. 18.1 ± 8.4 mm Hg, P = 0.006, peak velocity of 2.5 ± 0.6 vs. 2.9 ± 0.6 m/s, P = 0.003).ConclusionsTAVR is a safe and reasonable option for patients with small aortic annuli and is associated with shorter hospital stays and more favorable postoperative hemodynamic outcomes compared with SAVR. © 2017 Wiley Periodicals, Inc.
Homogeneous and Heterogeneous Nickel‐Catalyzed Olefin Oligomerization: Experimental Investigation for a Common Mechanistic Proposition and Catalyst Optimization
Authors: Forget Séverine , Olivier‐Bourbigou Hélène , Delcroix Damien 
Published: May 2017

AbstractOnly a few catalytic transformations can be efficiently catalyzed by both homogeneous or heterogeneous technologies, with short olefin oligomerization promoted by a nickel‐based catalysts among them. Homogeneous and heterogeneous catalysis are often opposed in terms of activity, active‐site description or recyclability, traditionally mentioned as “homogeneous versus. heterogeneous”. Unlike previous studies, we propose to emphasize the similarities between both catalysis by comparing industrially representative results obtained in continuous flow‐mode under similar mild conditions. A detailed analysis of both primary products of olefins oligomerization, and a set of secondary products obtained in experimental assays completed with recently published results of DFT calculations prompted us to postulate a common mechanistic pathway for nickel‐catalyzed ethylene oligomerization. Heterogeneous metallic ethylene oligomerization, for which nickel active sites identification has indeed long been under debate, seems to follow the Cossee–Arlman mechanism, well accepted as major mechanism in the homogeneous counterpart. This analysis allowed us to design an unprecedented heterogeneous catalyst active for ethylene and butene oligomerization.
Optimizing the Crystal Habit of Glycine by Using an Additive for Impinging Jet Crystallization
Authors: Tari Tímea , Ambrus Rita , Szakonyi Gerda , Madarász Dániel , Frohberg Patrick , Csóka Ildikó , Szabó-Révész Piroska , Ulrich Joachim , Aigner Zoltán 
Published: May 2017

AbstractAdditives selectively inhibit or enhance the growth of crystal faces and effectively change the crystal morphology. For the first time, potassium chloride was used as additive during impinging jet crystallization of glycine. The structure of the powder particles was evaluated by X‐ray powder diffraction, differential scanning calorimetry, scanning electron microscopy with energy dispersive X‐ray spectroscopy, headspace gas chromatography, and flame atomic absorption spectrometry. Even a minor amount of KCl had a significant effect on the crystal roundness and reduced the particle size significantly, despite of the extremely rapid nature of the crystallization process. This method resulted in the α‐polymorph of glycine with an appropriate low residual additive content and a minimal residual organic solvent content. The arrangement and the optimal concentration of the additive were determined.
KH2PO4 Production by Cooling Crystallization Using Its Phase Equilibrium in the KH2PO4‐KCl‐C2H5OH‐H2O System
Authors: Ren Yongsheng , Liu Jiamin , Ma Jingjing , Cai Chao 
Published: May 2017

AbstractSolid‐liquid phase equilibrium and physicochemical properties of the KCl‐KH2PO4‐C2H5OH‐H2O system at 313.15 K were investigated by the method of isothermal solution saturation, and the equilibrium solids were analyzed by Schreinemaker's method of wet residues and verified by XRD. Drowning‐out precipitation of KH2PO4 was carried out by mixing different ethanolic aqueous solutions, and crystal morphology was observed by polarizing microscopy. The phase diagrams exhibit one eutonic point, two univariant curves, and crystallization regions corresponding to KCl and KH2PO4. At all studied ethanol concentrations, the crystallization region of KH2PO4 is larger than that of KCl. The effect of KCl (ethanol) on crystal growth morphology and KH2PO4 product quality was studied.
Radio Frequency‐Based In Situ Determination of the Mass Loss of Supported Ionic Liquids
Authors: Anke Marie-Luise , Hämmerle Martin , Gerchau Jörg , Moos Ralf , Jess Andreas 
Published: May 2017

AbstractFor technical applications of supported ionic liquids (ILs), the stability of the IL layers both with regard to thermal decomposition and to losses by evaporation is of great importance. An innovative radio frequency‐based method is presented to determine the pore filling degree of supported ILs in situ and in a contactless way. As an example, the IL 1‐ethyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)imide, which was supported on the internal surface of porous silica, was selected. The complex permittivity of the porous solid coated with the IL increases linearly with the IL pore filling degree. Therefore, the evaporation rate of the IL in a fixed bed could be measured in situ in the reactor.
Size‐Controlled Hollow Spheres of C/α‐Fe2O3 Prepared through the Quasiemulsion‐Templated Method and Their Electrochemical Properties for Lithium‐Ion Storage
Authors: Kim Yoongon , Choi Eunjung , Kim Jong Guk , Lee Seungjun , Yoon Wongeun , Ham Moon‐Ho , Kim Won Bae 
Published: May 2017

AbstractIn this paper, α‐Fe2O3 hollow spheres in different sizes were successfully synthesized through a glycerol emulsion template method for use as efficient electrode materials in lithium‐ion batteries. The sizes of α‐Fe2O3 hollow sphere could be easily controlled by adjusting the amount of glycerol over the Fe precursor during the hydrothermal synthesis process. A thin carbon layer was subsequently coated on the surface of α‐Fe2O3 hollow spheres through hydrothermal treatment with glucose for the carbonization process, in which the carbon phases could serve as a conductive layer for the efficient charge transfer, but also as a buffer layer for the accommodation of volume vibration of the electrode material during cycling. The carbon‐coated α‐Fe2O3 hollow sphere electrode showed a high discharge capacity of approximately 1452 mAh g−1 with a capacity increase of at least 32 % compared to that of α‐Fe2O3 hollow spheres without the carbon coating at the 50th cycle. The stability and cycling performance were also significantly improved by the presence of the carbon layer, indicating that the C/α‐Fe2O3 hollow sphere could be a promising metal‐oxide anode material for lithium‐ion batteries.
The Versatile Behavior of Platinum Alkyne Complexes towards XeF2: Formation of Fluorovinyl and Fluorido Complexes
Authors: Berger Josefine , Braun Thomas , Ahrens Theresia , Kläring Paul , Laubenstein Reik , Braun‐Cula Beatrice 
Published: May 2017

AbstractReactions of platinum(0) tolane complexes, bearing a chelating ligand with P and N donor atoms, with the electrophilic fluorinating agent XeF2 give facile access to platinum(II) β‐fluorovinyl fluorido complexes. A series of new platinum(II) β‐fluorovinyl complexes have been synthesized and were structurally characterized. Further oxidation with XeF2 led to ortho‐metalated platinum(IV) fluorido compounds. Additional reactions of platinum(0) tolane complexes, bearing a chelating P,P donor ligand, with XeF2 led to a variety of fluorido and fluorovinyl complexes.
Responsive, Water‐Soluble Europium(III) Luminescent Probes
Authors: Shuvaev Sergey , Starck Matthieu , Parker David 
Published: May 2017

AbstractThe design principles, mechanism of action and performance of europium(III) complexes that serve as strongly emissive and responsive molecular probes in water are critically discussed. Examples of systems designed to assess pH, selected metal ions and anions, including chiral species, as well as selected small molecules and biopolymers are considered, and prospects evaluated for improved performance in more complex biological media such as in bio‐fluids and within living cells. Modulation of the emission spectral form, lifetime and degree of circular polarisation can be used to quantify the spectral response and permit calibration.
An Efficient Nickel‐Catalyzed Asymmetric Oxazole‐Forming Ugi‐Type Reaction for the Synthesis of Chiral Aryl‐Substituted THIQ Rings
Authors: Li Dan , Yang Dongxu , Wang Linqing , Liu Xihong , Wang Kezhou , Wang Jie , Wang Pengxin , Liu Yuyang , Zhu Haiyong , Wang Rui 
Published: May 2017

AbstractA nickel‐catalyzed asymmetric oxazole‐forming Ugi reaction of C,N‐cyclic azomethine imines and isonitriles is disclosed. The reported protocol proceeds smoothly, and gives the corresponding adducts, which contain two important pharmaceutically active ring‐systems (tetrahydroquinoline and oxazole rings), in good yields and excellent enantioselectivities by employing an easily accessible chiral diamine as a ligand. This simple and efficient strategy provides easy access to a series of C1‐substituted aryl tetrahydroisoquinolines.
Green Imidazolium Ionics–From Truly Sustainable Reagents to Highly Functional Ionic Liquids
Authors: Tröger‐Müller Steffen , Brandt Jessica , Antonietti Markus , Liedel Clemens 
Published: May 2017

AbstractWe report the synthesis of task‐specific imidazolium ionic compounds and ionic liquids with key functionalities of organic molecules from electro‐, polymer‐, and coordination chemistry. Such products are highly functional and potentially suitable for technology applications even though they are formed without elaborate reactions and from cheap and potentially green reagents. We further demonstrate the versatility of the used synthetic approach by introducing different functional and green counterions to the formed ionic liquids directly during the synthesis or after metathesis reactions. The influence of different cation structures and different anions on the thermal and electrochemical properties of the resulting ionic liquids is discussed. Our goal is to make progress towards economically competitive and sustainable task‐specific ionic liquids.
Synthesis and Properties of Functional Twisted Tolanes
Authors: Kozhemyakin Yury , Kretzschmar Andreas , Krämer Maximilian , Rominger Frank , Dreuw Andreas , Bunz Uwe H. F. 
Published: May 2017

AbstractThe synthesis and optical properties of several novel fluorescent and/or phosphorescent bridged tolanes (tolanophanes) are reported and their optical and structural properties are investigated. Specifically, diiodinated and bisalkynylated tolanophanes were obtained, and characterized by spectroscopy and computational methods. They represent attractive building blocks for novel polymers and emissive solid‐state materials.
Lanthanide Complexes in Molecular Magnetic Resonance Imaging and Theranostics
Authors: Lacerda Sara , Tóth Éva 
Published: May 2017

AbstractLanthanide complexes have attracted much attention in the biomedical field, and today various imaging applications make use of their versatile magnetic and luminescence properties. In this minireview, we give insight into the mechanistic aspects that allow modulation of the relaxation or chemical exchange saturation transfer (CEST) features, and thus the magnetic resonance imaging (MRI) efficiency of paramagnetic lanthanide chelates in order to create agents that are capable of providing an MRI response as a function of a specific biomarker. We focus on the detection of neurotransmitters, enzymatic activities, and amyloid peptides. We also describe two selected theranostic strategies: 1) a novel approach directed at monitoring drug release from liponanoparticles and 2) molecular or nanoparticle probes for the MRI visualization of photosensitizer delivery in photodynamic therapy.
Phase 1/2 study of rilotumumab (AMG 102), a hepatocyte growth factor inhibitor, and erlotinib in patients with advanced non–small cell lung cancer
Authors: Tarhini Ahmad A. , Rafique Imran , Floros Theofanis , Tran Phu , Gooding William E. , Villaruz Liza C. , Burns Timothy F. , Friedland David M. , Petro Daniel P. , Farooqui Mariya , Gomez‐Garcia Jose , Gaither‐Davis Autumn , Dacic Sanja , Argiris Athanassios , Socinski Mark A , Stabile Laura P. , Siegfried Jill M. 
Published: May 2017

BACKGROUNDActivation of the mesenchymal‐epidermal transition factor (MET) tyrosine kinase and its ligand, hepatocyte growth factor (HGF), is implicated in resistance to epidermal growth factor receptor (EGFR) inhibitors. In this phase 1/2 trial, rilotumumab (an anti‐HGF antibody) combined with erlotinib was evaluated in patients with metastatic, previously treated non–small cell lung cancer.METHODSIn phase 1, a dose de‐escalation design was adopted with rilotumumab starting at 15 mg/kg intravenously every 3 weeks and oral erlotinib 150 mg daily. In phase 2, the disease control rate (DCR) (according to Response Evaluation Criteria in Solid Tumors) of the combination was evaluated using a Simon 2‐stage design. The biomarkers examined included 10 plasma‐circulating molecules associated with the EGFR and MET pathways.RESULTSWithout indications for de‐escalation, the recommended phase 2 dose was dose level 0. Overall, 45 response‐evaluable patients were enrolled (13 with squamous carcinoma, 32 with adenocarcinoma; 2 had confirmed EGFR mutations, 33 had confirmed wild‐type [WT] EGFR, and 7 had KRAS mutations). The DCR for all patients was 60% (90% confidence interval [CI], 47.1%‐71.3%). Median progression‐free survival was 2.6 months (90% CI, 1.4‐2.7 months), and median overall survival was 6.6 months (90% CI, 5.6‐8.9 months). Among patients with WT EGFR, the DCR was 60.6% (90% CI, 46.3%‐73.3%), median progression‐free survival was 2.6 months (90% CI, 1.4‐2.7 months), and median overall survival was 7.0 months (90% CI, 5.6‐13.4 months). Elevated baseline levels of neuregulin 1 were associated with longer progression‐free survival (hazard ratio, 0.41; 95% CI, 0.19‐0.87), whereas elevated amphiregulin levels were associated with more rapid progression (hazard ratio, 2.14; 95% CI, 1.48‐3.08).CONCLUSIONSCombined rilotumumab and erlotinib had an acceptable safety profile, and the DCR met the prespecified criteria for success. In the EGFR WT group, the DCR exceeded published reports for erlotinib alone. High circulating levels of neuregulin 1 may indicate sensitivity to this combination. Cancer 2017;123:2936–44. © 2017 American Cancer Society.
The persistent promise of combining HGF/MET and EGFR inhibition in non‐small cell lung cancer
Authors: Chuang Jody C. , Neal Joel W. 
Published: May 2017

Hepatocyte growth factor/mesenchymal‐epidermal transition factor (MET) dysregulation is a viable target in non‐small cell lung cancer, both alone and potentially in combination with epidermal growth factor receptor inhibition. Future trials involving epidermal growth factor receptor and MET inhibitors should focus on more selected patient populations and include relevant biomarker studies.See also pages 2936‐44.