bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of Acute Haemodynamic Outcomes of the Surgical Strategies for the Right Ventricular Failure Treatment in Pediatric LVAD
Authors: Di Molfetta Arianna , Ferrari Gianfranco , Iacobelli Roberta , Filippelli Sergio , Fresiello Libera , Gagliardi Maria G. , Toscano Alessandro , Trivella Maria G. , Amodeo Antonio 
Published: February 2016

Background Right ventricular failure (RVF) is one of the major complications during LVAD. Apart from drug therapy, the most reliable option is the implantation of RVAD. However, BIVAD have a poor prognosis and increased complications. Experiments have been conducted on alternative approaches, such as the creation of an atrial septal defect (ASD), a cavo-aortic shunt (CAS) including the LVAD and a cavo-pulmonary connection (CPC). This work aims at realizing a lumped parameter model (LPM) to compare the acute hemodynamic effects of ASD, CPC, CAS, RVAD in LVAD pediatric patients with RVF. Methods Data of 5 pediatric patients undergoing LVAD were retrospectively collected to reproduce patients baseline hemodynamics with the LPM. The effects of continuous flow LVAD implantation complicated by RVF was simulated and then the effects of ASD, CPC, CAS and RVAD treatments were simulated for each patient. Results The model successfully reproduced patients' baseline and the hemodynamic effects of the surgical strategies. Simulating the different surgical strategies, an unloading of the right ventricle and an increment of left ventricular preload were observed with an improvement of the hemodynamics (total cardiac output: ASD +15%, CPC +10%, CAS +70% RVAD +20%; right ventricular external work: ASD -19%, CPC -46%, CAS -76%, RVAD -32%; left ventricular external work: ASD +12%, CPC +28%, RVAD +64%). Conclusions The use of numerical model could offer an additional support for clinical decision-making, also potentially reducing animal experiments, to compare the outcome of different surgical strategies to treat RVF in LVAD.
Clinical Prognostic Value of Metastasis-Associated Lung Adenocarcinoma Transcript 1 in Various Human Cancers: An Updated Meta-Analysis
Authors: Li Yang , Yang Ze , Wan Xiaoya , Zhou Jianguo , Zhang Yu , Ma Hu , Bai Yuju 
Published: February 2016

Background Many studies have investigated the prognostic value of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in human cancers. However, these studies were often limited by small sample sizes. Therefore, we performed this updated meta-analysis to summarize the potential value of MALAT1 as a biomarker for early treatment and to predict survival in various human malignant neoplasms, through the inclusion of the latest literature and improved methodology. Methods Twelve eligible articles were systematically obtained from PubMed, Medline, Embase, Web of Science, China National Knowledge Infrastructure and the Cochrane Library, from inception up to June 30, 2015. Survival was assessed using pooled hazard ratios (HRs) and 95% confidence intervals (95% CIs). Results By combining the results of 12 studies, we found elevated MALAT1 expression was associated with poor survival in most cancers, with a pooled HR of 1.90 (95% CI, 1.56-2.30) for overall survival (OS) and 3.06 (95% CI, 2.06-4.56) for recurrence-free survival/disease-free survival. Subgroup analyses according to ethnicity, tumor type, assay method, sample size, HR-calculation method and analysis type did not affect the predictive role of MALAT1 for OS in various cancer types. Further, by combining results from studies that used multivariate analyses, we found elevated MALAT1 was an independent prognostic factor for OS (HR = 1.98; 95% CI, 1.58-2.48). Conclusions MALAT1 could serve as a potential prognostic biomarker in various cancers and may be a potential therapeutic target for the treatment and early detection of recurrence.
A new Infraclavicular Landmark-Based Approach to the Axillary Vein as an Alternative Method of Central Venous Cannulation
Authors: Gawda Ryszard , Czarnik Tomasz , Weron Rafal , Nowotarski Jakub 
Published: February 2016

Purpose We developed the new technique of the axillary vein catheterization, which is connected with the determination of only two anatomical points of reference for puncture site identification. The primary outcome of this study was to determine the rate of successful catheterizations and the assessment of procedure success rate, depending on cannulation side as well as physician experience. The secondary objective was to evaluate the early complication rate and to determine whether this method can be used in clinical practice. Methods The methodology of this prospective, cohort study included catheterization of the axillary vein via the infraclavicular approach. All procedures were performed by the first two authors, each of whom had different levels of experience with the technique. The choice of the cannulation side was based on clinical factors, and the technique was identical on the right and left sides. Results The cannulation success rate reached 85.6% (N = 153). The correlation between physician experience and the procedure success rate as well as between cannulation side and procedure success rate were not significant. A common early complication was a puncture of axillary artery (14.4%) with the following proper cannulation in the majority of patients (77.3%, p<0.01, exact test). Conclusions The procedure success rate, 85.6% (95% CI [80.0, 91.2%]), is comparable to other landmark-based techniques of the central vein cannulation. The moderately high percentage of axillary artery puncture points out that the approach should be used only as an alternative method to the central vein catheterization.
Which Arm and Vein are more Appropriate for Single-Step, Non-Fluoroscopic, Peripherally Inserted Central Catheter Insertion?
Authors: Jeon Eui-Yong , Cho Young K. , Yoon Dae Y. , Hwang Jin Ho 
Published: February 2016

Objective We investigated which arm and vein led to the most successful outcomes during non-fluoroscopic peripherallyinserted central catheter (PICC) insertion. Methods A total of 743 cases from July 2012 to March 2014 were retrospectively reviewed. We also analyzed the following: 1) accessed arm (right or left), 2) accessed vein (cephalic, basilic, or brachial), 3) primary and secondary success rates, 4) causes of failure (location of obstacles), and 5) problemsolving methods for catheter repositioning. Results The primary success rate was 46.3% (344/743) with 49.4% (123/249) on the right arm and 44.7% (273/494) on the left arm. The secondary success rate was 53.7% (399/743) with 50.6% (126/249) on the right arm and 55.3% (273/494) on the left arm. The causes of failure were 100% (43/43) for the left cephalic vein, 61.5% (8/13) for the right cephalic vein, 50.6% (43/85) for the left brachial vein, and 51.1% (23/45) for the right brachial vein, 51.1% (187/366) for the left basilic vein, and 49.7% (95/191) for the right basilic vein. The failure rate through the left cephalic vein was significantly higher than that for other veins. The most common locations of obstacles were the subclavian vein (28.8%, 115/399), axillary vein (24.3%, 97/399), and brachiocephalic vein (19.3%, 77/399). The most common problem-solving methods were with guidewire assistance (74.7%, 298/399), venographic guidance (13.8%, 55/399), and fluoroscopic guidance (11.5%, 46/399). Conclusions Right-arm access through the basilic or brachial vein may be more appropriate for successful nonfluoroscopic PICC insertion compared with the access through the left arm and the cephalic vein.
Systematic Review of Drug Eluting Balloon Angioplasty for Arteriovenous Haemodialysis access Stenosis
Authors: Khawaja Aurang Z. , Cassidy Deirdre B. , Shakarchi Julien Al , McGrogan Damian G. , Inston Nicholas G. , Jones Robert G. 
Published: February 2016

Background Native or prosthetic arteriovenous (AV) fistulas are preferred for permanent haemodialysis (HD) access. These are marked with circuit steno-occlusive disease leading to dysfunction or even failure. Late failure rates have been reported as high as 50%. Standard angioplasty balloons are an established percutaneous intervention for HD access stenosis. Reported restenosis rates remain high and practice guidelines recommend a wide 6-month primary patency (PP) of at least 50% for any intervention. Neointimal hyperplasia is one of the main causes for access circuit stenosis. Drug eluting balloon (DeB) angioplasty has been proposed as an alternative intervention to reduce restenosis by local drug delivery and possible inhibition of this process. Purpose To systematically assess the reported efficacy and safety of DeB angioplasty in percutaneous management of prosthetic and autologous HD access stenosis. Methods Protocol for the review was developed following the PRISMA-P 2015 statement. An electronic database (Medline, EMBASE, Clinical Trials.gov and Cochrane CENTRAL) search was conducted to identify articles reporting on the use of DeB intervention in HD AV access. Backward and forward citation search as well as grey literature search was performed. The MOOSE statement and PRISMA 2009 statement were followed for the reporting of results. Data from the included studies comparing DeBs with non-DeBs were pooled using a random effects metaanalysis model and reported separately on randomised and non-randomised studies. Results Six studies reported on 254 interventions in 162 participants (mean 27 ± 10 SD). The pooled mean and median duration of follow-up was 12 and 13 months (range 6-24 months). These comprised two randomised control trials (RCTs) and four cohort studies. Participant's mean age was 64 ± 5 years and 61% were male. Target lesions (TLs) ranged from under 2 mm to 5.9 mm and 51 were reported as de novo stenosis. Device failure described as wasting of the DeB was reported in two studies (55% and 92.8%). At 6 months TL PP was reported between 70% to 97% for DeBs in the RCTs and cohort studies, and 0% to 26% for non-DeBs. TLs treated with DeBs were associated with a higher primary patency at 6 months as compared to non-DeB balloons (RCTs: odds ratio [OR] 0.25, 95% CI 0.08 to 0.77 and I2 = 19%, cohort studies: OR 0.10, 95% CI 0.03 to 0.31 and an I2 = 20%). No procedure-related major or minor complications were reported. Conclusions Current literature reports DeBs as being safe and may convey some benefit in terms of improved rate of restenosis when used to treat AV access disease. However, this body of evidence is small and clinically heterogeneous. A large multicentre RCT may help to clarify the role of DeBs in the percutaneous treatment of AV HD access stenosis.
El potencial de los museos en la conservación del patrimonio cultural
Authors: Campos Solórzano Melissa Regina 
Published: February 2016

El artículo es el resultado de una reflexión que parte de la investigación titulada “Propuesta para un museo sin muros para la reactivación de la memoria urbana en la calle Arce”, que buscó formular una propuesta museológica de exposición en la vía pública para crear un vínculo real entre la comunidad y el Patrimonio Cultural del Centro Histórico de San Salvador, iniciada en 2011, a partir de los estudios en Maestría en Patrimonio Cultural y Territorio realizados en la Pontificia Universidad Javeriana de Colombia, tomando como caso de estudio el proceso de reordenamiento de la calle Arce en la ciudad de San Salvador, El Salvador, Centroamérica.
Registro y documentación histórica del pecio SS Colón en Acajutla, Departamento de Sonsonate. El Salvador
Authors: Gallardo Mejía Francisco Roberto 
Published: February 2016

El tránsito de buques a vapor en el Océano Pacífico entre 1850 y principios de 1900s fue un fenómeno histórico descomunal en América y marca la época de oro en la navegación con máquinas impulsadas con este tipo de combustión.Durante este periodo de tiempo se estableció un complejo sistema de transporte y comunicación que unió los continentes y constantemente se rompieron marcas de tiempo en viajes marinos y capacidad de carga.Este fenómeno náutico fue vital para el desarrollo industrial y económico de muchos países en el continente americano. La gran cantidad de productos que eran transportados por estos buques incluyendo añil y café generaron los ingresos para hacer posible el desarrollo de los países que contaban con puertos en el Océano Pacífico.El transporte de miles de pasajeros con diversas profesiones y especialidades o simples aventureros que buscaban una mejor vida también propició el traslado de conocimiento para el impulso tecnológico de muchas naciones americanas.
Los bienes temporales de la iglesia: tesoros sagrados para la comunidad cristiana y tesoros culturales para los pueblos
Authors: Marcelino Regalado Roque 
Published: February 2016

“La visión antropomórfica en las religiones como fundamento de la expresión artística de la fe”En la mayoría de religiones el hombre siempre ha expresado las realidades trascendentes con una visión antropomórfica.En especial en el judaísmo como en el cristianismo, esta visión ha llevado a atribuir características a Dios que han inspirado la representación plástica del mismo. Así, cuando se describe en los textos sagrados que Dios oye, ve, camina con su pueblo, abraza, golpea, tiene una espada en su mano, etc.Son expresiones de la cercanía de la trascendencia de Dios. Esta expresión plástica con el paso del tiempo en el cristianismo tomó forma en las artes occidentales de tal manera que la cultura plástica de los pueblos se vio revestida de sacralidad.Sin embargo, con la llegada de la cultura moderna, con su producción en masa y la visión de lo desechable, nos ha hecho perder el valor de lo sagrado y de lo cultural. Es necesario recobrar el espíritu de la humanidad y los valores que de la cultura y la fe emanan.
José Martí en la hora de la integración latinoamericana y caribeña
Authors: Prada Pedro P. 
Published: February 2016

Pido ante todo transmitir un afectuoso saludo a nuestro amigo, el Dr. José Mauricio Loucel, Presidente de la Junta General Universitaria, a quien debemos este feliz encuentro. Igualmente, ruego saludar al Sr. Rector, Ing. Nelson Zárate.Agradezco profundamente a la Universidad Tecnológica de El Salvador la decisión de acoger hoy, 28 de enero de 2013, este evento dedicado a rendir tributo a un ser humano excepcional y a sus ideas; que nació en Cuba, vivió, padeció y murió por ella, pero cuyo legado pertenece por derecho propio a todos los pueblos de Nuestra América y a la humanidad entera, a la que declaró como su Patria.
Determination of Vitamin E and Vitamin A in Infant Formula and Adult Nutritionals by Normal-Phase High-Performance Liquid Chromatography: Collaborative Study, Final Action 2012.10
Authors: McMahon Adrienne ,   Collaborators:, Christiansen S , Chee F-F , Chua A , Braddock H , Gill B , De Guzman R , Kohler K , Labitan D P , Larkin G , Le Grandois J , Marceau E , Martin F , Meng Jensen S , Meyer L , Piot D , Rael L , Schimpf K , Thompson M , Torres M 
Published: February 2016

Abstract
The main objective of the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) project is to establish international consensus methods for infant formula and adult nutritionals, which will benefit intermarket supply and dispute resolution. A collaborative study was conducted on AOAC First Action Method 2012.10 Simultaneous Determination of 13-cis and All-trans Vitamin A Palmitate (Retinyl Palmitate), Vitamin A Acetate (Retinyl Acetate), and Total Vitamin E (α-Tocopherol and D-α-tocopherol acetate) in Infant Formula and Adult Nutritionals by Normal-Phase HPLC. Fifteen laboratories from 11 countries participated in an interlaboratory study to determine 13-cis and all-trans vitamin A palmitate (retinyl palmitate), vitamin A acetate (retinyl acetate), and total vitamin E (α-tocopherol and D-α-tocopherol acetate) in infant formula and adult nutritionals by normal-phase HPLC and all laboratories returned valid data. Eighteen test portions of nine blind duplicates of a variety of infant formula and adult nutritional products were used in the study. The matrixes included milk-based and soy-based hydrolyzed protein as well as a low fat product. Each of the samples was prepared fresh and analyzed in singlicate. As the number of samples exceeded the recommended number to be prepared in a single day, analysis took place over 2 days running 12 samples on day one and 10 samples on day two. The reference standard stock was prepared once and the six-point curve diluted freshly on each day. Results obtained from all 15 laboratories are reported. The RSDR for total vitamin A (palmitate or acetate) ranged from 6.51 to 22.61% and HorRat values ranged from 0.33 to 1.25. The RSDR for total vitamin E (as tocopherol equivalents) ranged from 3.84 to 10.78% and HorRat values ranged from 0.27 to 1.04. Except for an adult low fat matrix which generated reproducibility RSD &gt;40% for some isomers, most SPIFAN matrixes gave results within the acceptance criteria of &lt;16% RSD as stated in the respective Standard Method Performance Requirements.
Determination of Sodium Fluoroacetate in Dairy Powders by Liquid Chromatography–Tandem Mass Spectrometry: Single-Laboratory Validation, First Action 2015.02
Authors: Fleury Lauren M , Scahill Bryan G , Taskova Rilka 
Published: February 2016

Abstract
A single-laboratory validation (SLV) study was conducted for the determination of sodium fluoroacetate in dairy powders by LC-tandem MS (LC-MS/MS). Linearity of response was confirmed by analysis of samples fortified over the concentration range 0.10–100 μg/kg. The LOD was estimated to be 0.028 μg/kg (0.028 ppb) from the SD of the measured concentrations of infant formula samples fortified at 0.10 μg/kg. The corresponding LOQ calculates at 0.085 μg/kg (0.085 ppb), which ensures excellent reliability of quantification at the limit of reporting of 1.0 μg/kg (1 ppb). Repeatability and intermediate precision were estimated from the SD of the recovery of samples fortified at 0.075, 0.10, 0.20, 0.50, 1.0, and 10.0 μg/kg. The previously mentioned method performance values were established using a representative stage 2 (6–12 months) bovine infant formula, and the robustness of the method was tested by the analysis of 107 unique dairy powders and formulations fortified at 1.0 μg/kg. The data collected in this study satisfy the requirements of SLV studies established by the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN), and the method was awarded First Action Official MethodSM status by the AOAC Expert Review Panel on SPIFAN Nutrient Methods (Contaminants) on March 17, 2015.
Unique manifestations of mixed‐phase cloud microphysics over Ross Island and the Ross Ice Shelf, Antarctica
Authors: Scott Ryan C. , Lubin Dan 
Published: February 2016

AbstractSpaceborne radar and lidar observations from the CloudSat and CALIPSO satellites are used to compare seasonal variations in the microphysical and radiative properties of clouds over Ross Island, Antarctica, with two contrasting Arctic atmospheric observatories located in Barrow, Alaska, and Summit, Greenland. At Ross Island, downstream from recurrent intrusions of marine air over the West Antarctic Ice Sheet and eastern Ross Ice Shelf, clouds exhibit a tendency toward the greatest geometrical thickness and coldest temperatures in summer, the largest average ice water content, IWC, at low altitude during summer and autumn, the most abundant IWC at cold mixed‐phase temperatures (−40°C <T< −20°C), and the strongest impact from ice water on the surface energy budget year round, all with likely origins in orographic lifting of marine air over complex ice sheet and mountainous terrain. Clouds over Barrow form and evolve in a contrastingly warm and moist atmosphere and on average contain the largest liquid water content and ice and liquid water effective particle radii, re, year round. In contrast, clouds observed atop the central Greenland Ice Sheet are relatively tenuous, containing the smallest IWC and ice re of all sites.
El Niño–Southern Oscillation influence on tropospheric mercury concentrations
Authors: Slemr Franz , Brenninkmeijer Carl A. , Rauthe‐Schöch Armin , Weigelt Andreas , Ebinghaus Ralf , Brunke Ernst‐Günther , Martin Lynwill , Spain T. Gerard , O'Doherty Simon 
Published: February 2016

AbstractThe El Niño–Southern Oscillation (ENSO) affects the tropospheric concentrations of many trace gases. Here we investigate the ENSO influence on mercury concentrations measured in the upper troposphere during Civil Aircraft for the Regular Investigation of the atmosphere Based on an Instrumented Container flights and at ground at Cape Point, South Africa, and Mace Head, Ireland. Mercury concentrations cross‐correlate with Southern Oscillation Index (SOI) with a lag of 8 ± 2 months. Highest mercury concentrations are always found at the most negative SOI values, i.e., 8 months after El Niño, and the amplitude of the interannual variations fluctuates between ~5 and 18%. The time lag is similar to that of CO whose interannual variations are driven largely by emissions from biomass burning (BB). The amplitude of the interannual variability of tropospheric mercury concentrations is consistent with the estimated variations in mercury emissions from BB. We thus conclude that BB is a major factor driving the interannual variation of tropospheric mercury concentrations.
Potassium Phosphate‐Catalyzed Chemoselective Reduction of α‐Keto Amides: Route to Synthesize Passerini Adducts and 3‐Phenyloxindoles
Authors: Muthukumar Alagesan , Mamillapalli N. Chary , Sekar Govindasamy 
Published: February 2016

AbstractA chemoselective reduction of α‐keto amides to biologically important α‐hydroxy amides (mandelamides) by polymethylhydrosiloxane (PMHS) using 5 mol% potassium phosphate (K3PO4) as catalyst has been developed. This transition metal‐free protocol discloses excellent chemoselectivity for the ketone reduction of α‐keto amides in the presence of other reducible functionalities like ketone, nitro, halides, nitrile and amide. Also, the chemoselectively reduced α‐hydroxy amide has been derivatized to isocyanide‐free Passerini adducts. The N‐alkyl‐α‐hydroxy amides have been successfully converted to 3‐phenyloxindole derivatives by treatment with methanesulfonyl cholride and triethylamine.magnified image
Influence of Carboxylic Acids on Poly(lactic acid)/Thermoplastic Starch Biodegradable Sheets Produced by Calendering–Extrusion
Authors: Shirai Marianne Ayumi , Zanela Juliano , Kunita Marcos Hiroiuqui , Pereira Guilherme Miranda , Rubira Adley Forti , Müller Carmen Maria Olivera , Grossmann Maria Victória Eiras , Yamashita Fabio 
Published: February 2016

ABSTRACTSheets of poly(lactic acid) (PLA) and thermoplastic starch (TPS) with citric and adipic acid additives were produced through a calendering–extrusion process at pilot scale, and its mechanical, barrier, thermal, and morphological characteristics were determined. According to the micrographs, citric acid improved the fragmentation and dispersion of starch granules by facilitating interactions with PLA chains and increasing interfacial adhesion. Citric acid also induced a significant increase in the tensile strength and elongation at break, reducing water vapor permeability, increasing crystallinity, but decreased slightly the thermal stability. Adipic acid did not demonstrate the same efficiency, even when mixed with citric acid.