bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plurivascular Lesions in Patients with Peripheral Arterial Disease
Authors: Kelemen Piroska , Kolbert Beáta Katalin , Szabó Mónika , Kelemen Hanga , Radu Achim , Stan Alwina Ana 
Published: October 2016

Abstract

Introduction: Occlusive arterial disease, regardless of etiology, is a progressive chronic disease with multiple vessel involvement. The importance of obstructive arterial disease is that it leads to an increased mortality and morbidity of other cardiovascular disorders. Therefore, the presence of a lesion on a certain artery should lead to the identification of other lesions on the carotid and coronary arteries. The aim of the study was to assess the frequency and severity of lesions in peripheral arterial disease of different etiologies, and also to study its association with multivessel lesions at the level of the coronary tree and the carotid arteries.

Material and methods: We performed a retrospective study on 177 patients with previously diagnosed peripheral artery disease that were admitted to the 2nd Medical Clinic of the County Emergency Clinical Hospital of Tîrgu Mureș. The patients underwent evaluation of the peripheral artery disease (clinical, arterial Doppler), as well as of the coronary artery disease (clinical, ECG) and the carotid arteries (auscultation, Doppler Duplex ultrasound). The study population was divided into three groups: group 1 – diabetic arteriopathy (n = 79); group 2 – atherosclerotic obstructive arteriopathy (n = 77); group 3 – thromboangiitis obliterans (n = 21).

Results: The patients' age ranged between 61 and 70 years. Arterial occlusions were found in 87% of cases in group 1. Suboclussions were more frequent in diabetics (11.4%). The artery, in which we found lesions in the highest percentage was the left femoral artery (group 1 – 68.3%, group 2 – 66.23%, group 3 – 42.85%). The second most often affected artery was the right femoral artery, with a 64.45% rate of involvement. In patients with thromboangiitis obliterans, the right anterior tibial artery was the most frequently affected (15.81%). The most frequent coronary lesion was a stenosis of 30–69%, in 35.02% of cases. Three-vessel coronary disease had an incidence of 44.2% in the atherosclerotic group, 34.2% in diabetics, and 23.8% in the thromboangiitis group. From the total rate of previously diagnosed myocardial infarction (MI) – 29.37% (n = 52), 50% were atherosclerotic, 44.23% diabetic, and 5.76% with thromboangiitis. At the level of the carotid system, 68.9% of patients were found to have stenoses under 70%. From these, 48.4% were patients with diabetic arteriopathy, 44.3% with atherosclerotic disease. In 73.4% of cases, we found lesions at all three levels — in case of diabetic and nondiabetic arteriopathy and thromboangiitis, only 14.3% of patients had associated lesions.

Conclusions: Atherosclerosis (diabetic and nondiabetic) and thromboangiitis obliterans are diseases with plurivascular involvement. It is important to diagnose concomitant coronary and carotid lesions in patients with chronic occlusive arterial illness, because they are often associated.
Maternal and neonatal outcomes following expectant management of preterm prelabour rupture of membranes before viability
Authors: Sim Winnie Huiyan , Araujo Júnior Edward , Da Silva Costa Fabricio , Sheehan Penelope Marie 
Published: October 2016

Abstract

Aim:
To assess the contemporary maternal and neonatal outcomes following expectant management of preterm premature rupture of membranes (PPROM) prior to 24 weeks’ gestation and to identify prognostic indicators of this morbid presentation.

Methods:
We performed a systematic review in the Pubmed and EMBASE databases to identify the primary (perinatal mortality, severe neonatal morbidity and serious maternal morbidity) and secondary (neonatal survival and morbidity) outcomes following expectant management of previable PPROM.

Results:
Mean latency between PPROM and delivery ranged between 20 and 43 days. Women with PPROM <24 weeks had an overall live birth rate of 63.6% and a survival-to-discharge rate of 44.9%. The common neonatal morbidities were respiratory distress syndrome, bronchopulmonary dysplasia and sepsis. The majority of neonatal deaths within 24 h post birth were associated with pulmonary hypoplasia, severe intraventricular haemorrhage and neonatal sepsis. The common maternal outcomes were chorioamnionitis and caesarean sections. The major predictors of neonatal survival were later gestational age at PPROM, adequate residual amniotic fluid levels, C-reactive protein <1 mg/dL within 24 h of admission and PPROM after invasive procedures.

Conclusion:
Pregnancy latency and neonatal survival following previable PPROM has improved in recent years, although neonatal morbidity remains unchanged despite recent advances in obstetric and neonatal care. There is heterogeneity in management practices across centres worldwide.
Women professionals’ participation in the nigerian construction industry: finding voice for the voiceless
Authors: Jimoh Richard Ajayi , Oyewobi Luqman Oyekunle , Adamu Amina Nna , Bajere Paul Abayomi 
Published: October 2016

Abstract
The construction industry is a male-dominated industry globally, with poor women representation in every facet of the construction profession and the involved jobs. In this context, this study investigated the current level of women participation, challenges faced by professional women, factors that influence them in the course of developing careers in construction and the criteria that can be used to encourage women participation in the Nigerian construction industry. This was done through self-administration of 145 structured questionnaires to 93 women professionals in the built environment and 52 employers of built environment labour in Abuja, Nigeria. The analyses showed that the construction industry is largely dominated by men, with women having a lot of challenges ranging from lack of self-confidence to compete with their male counterparts to insecurity in the midst of men to execute their work as professionals. Therefore, the study recommends that making young women aware of construction industry opportunities is needed to encourage them to build their careers in construction from the school stage in order to increase the number of professional women participating in the future. In addition to this, professional women should be given equal job opportunities as their male counterparts to ensure better representation of women so that the impact of women professionals in the construction industry can be extended.
Effect of Cultural Intelligence on the Work Adjustment of PE Teachers in Primary and Secondary Schools in a Large City in Iran
Authors: Mirsafian Hamidreza 
Published: October 2016

AbstractThis study aimed to measure the cultural intelligence of physical education (PE) teachers’ work adjustment in primary and secondary schools in a large city in Iran (Isfahan). The method of this research was descriptive (correlation) and the total population included all of the PE teachers at three educational levels in Isfahan in 1393 (2014) (N= 559). Participants (N= 226) were selected by using the stratified random sampling method according to the total population of the PE teachers in all six educational regions of Isfahan. A self-constructed cultural intelligence questionnaire (20 items) as well as a work adjustment scale (Davis & Lofqist, 1991) including 20 items were employed in this research. The regression and correlation tests were used for analyzing data. The results indicated that cultural intelligence significantly affects the PE teachers’ work adjustment. There was also a significant correlation between cultural intelligence and the PE teachers’ work adjustment.
Forming of Students’ Professional Legal Competency: Foreign Experience
Authors: Yashchuk Sergiy 
Published: October 2016

AbstractThe article deals with analysis of future social workers’ training in the context of forming students’ professional legal competency in higher education institutions of European Union (EU), the USA and Ukraine. Based on the study of scientific and reference sources the peculiarities of the educational process in the most popular higher education institutions, particularly, in EU, offering Bachelor’s and Master’s degrees in Social Work have been defined: in France there is no distinct differentiation between social workers and social pedagogues; these professions successfully combine functions of education and assistance; future social workers are trained in centers and universities that follow instructions of French National Academy for Youth Protection and Juvenile Justice; at German universities social work curricula are based on threefold study load of future specialists: world societies and social development, social problems and human rights violation, international rights in social work; are interdisciplinary and can be realized in cooperation with other European universities; at British universities teachers have great practical experience in social work; student body is cosmopolitan, i.e. a mixture of mature and young students from different ethnic groups and nationalities; curricula also provide for a large volume of practical learning in working conditions corresponding to national requirements; in Spain future specialists are trained for three appropriate segments of labour market, namely, law, social work expert and Master in Social Work (such specializations as social mediation, leisure time activities, professional adaptation).
The Essence and Structure of Masters’ of Public Administration Core Competencies in the USA
Authors: Shevchenko Alina 
Published: October 2016

Abstract
The article deals with revealing the essence and structure of Masters’ of Public Administration professional training in the USA. It has been concluded that Public Administration studies the realization of government policies and trains future public administrators for professional activity; is guided by political science and administrative law; aims to improve the justice, equality, security and efficiency of public services. It has been indicated that the MPA degree is dedicated for those willing to work in public sector. It has been found out that MPA programs are designed to develop the abilities, skills and methods specialists use to realize policies, programs and projects as well as to resolve crucial issues within their organization and/or in society. It has been stated that in the United States of America Master of Public Administration (MPA) and Master of Business Administration programs (MBA) are quite similar, however, have certain differences. It has been defined that the MPA program focuses on different ethical and sociological criteria secondary for business administrators. Simultaneously MPA programs encompass economy courses to supply students with knowledge of microeconomic and macroeconomic issues. It has been specified that MPA programs are built on a range of core competencies defined by the Network of Schools of Public Policy, Affairs, and Administration (NASPAA). The list of the core competencies (to lead and manage in public governance; to participate in and contribute to the public policy progress; to analyze, synthesize, think critically, solve problems and make decisions; to articulate and apply a public service perspective; to communicate and interact productively with a diverse and changing workforce and citizenry) and their detailed characteristics have been presented. It has been identified that cultural competency of future public administrators has become an essential constituent of public affairs curricula. It has been concluded that the above-mentioned positive aspects of the experience may be used to improve future public administrators’ professional training in Ukraine.
On the influence of overconsolidation effect on the compressibility assessment of subsoil by means of CPTU and DMT
Authors: Młynarek Zbigniew , Wierzbicki Julian , Lunne Tom 
Published: October 2016

Abstract
The paper contains the analysis of the influence of overconsolidation effect on the values of constrained moduli, assumed by means of two most popular in situ advanced tests. The tested soils included two geological formations: normally consolidated tills of the Pomeranian phase and overconsolidated tills of the Posnanian phase. The overconsolidation ratio (OCR) was derived from CPTU, DMT and oedometric tests. The tests revealed that for the assessment of changes in constrained modulus in the subsoil with CPTU and DMT, the formulas determining the relationship between cone resistance, DMT results and constrained moduli requires empirical coefficient different for soils of varied genesis.
Estimating and verifying soil unit weight determined on the basis of SCPTu tests
Authors: Bagińska Irena 
Published: October 2016

Abstract
The unit weight, as a basic physical feature of soil, is an elementary quantity, and knowledge of this parameter is necessary in each geotechnical and geo-engineering task. Estimation of this quantity can be made with both laboratory and field techniques. The paper comprises a multi-scale evaluation of unit weight of cohesive soil, based on several measurements made in nearby locations using the SCPTu static probe. The procedures used were based on the two classifications and two solutions from literature. The results were referenced to the actual values of unit weight determined with a direct procedure from undisturbed samples. The resulting solutions were the basis for proposing a new formula to determine the soil unit weight from SCPTu measurements, as well as comparative analysis using exemplary values taken from the national Polish standard.
Mercury Retrograde Effect in Capital Markets: Truth or Illusion?
Authors: Murgea Aurora 
Published: October 2016

Abstract
From the most ancient times, the astrological beliefs have played an important role in human history, thinking, world-views, language and other elements of social culture. The practice of relating the movement of celestial bodies to events in financial markets is relatively newer but despite the inconsistency between financial astrology and standard economic or financial theory, it seems to be largely spread among capital market traders. This paper evaluates one of the astrological effects on the capital market, more precisely the Mercury retrograde effect on US capital market. Despite the fact that it is just an optical illusion the astrological tradition says that Mercury retrograde periods are characterized by confusion and miscommunications. The trades could be less effective, the individuals more prone to make mistakes so there is a long-held belief that it is better to avoid set plans during Mercury retrograde, signing contracts, starting new ventures or open new stock market positions. The main findings of this study are lower return’s volatilities in the Mercury retrograde periods, inconsistent with the astrologic theories assumptions but consistent with the idea that trader’s beliefs in Mercury retrograde effect could change the market volatility exactly in the opposite sense than the predicted one.
TECRL, a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT
Authors: Devalla Harsha D , Gélinas Roselle , Aburawi Elhadi H , Beqqali Abdelaziz , Goyette Philippe , Freund Christian , Chaix Marie‐A , Tadros Rafik , Jiang Hui , Le Béchec Antony , Monshouwer‐Kloots Jantine J , Zwetsloot Tom , Kosmidis Georgios , Latour Frédéric , Alikashani Azadeh , Hoekstra Maaike , Schlaepfer Jurg , Mummery Christine L , Stevenson Brian , Kutalik Zoltan , de Vries Antoine AF , Rivard Léna , Wilde Arthur AM , Talajic Mario , Verkerk Arie O , Al‐Gazali Lihadh , Rioux John D , Bhuiyan Zahurul A , Passier Robert 
Published: October 2016

AbstractGenetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole‐exome sequencing (WES) was carried out on patients from three different families that presented with life‐threatening arrhythmias and high risk of sudden cardiac death (SCD). Two French Canadian probands carried identical homozygous rare variant in TECRL gene (p.Arg196Gln), which encodes the trans‐2,3‐enoyl‐CoA reductase‐like protein. Both patients had cardiac arrest, stress‐induced atrial and ventricular tachycardia, and QT prolongation on adrenergic stimulation. A third patient from a consanguineous Sudanese family diagnosed with catecholaminergic polymorphic ventricular tachycardia (CPVT) had a homozygous splice site mutation (c.331+1G>A) in TECRL. Analysis of intracellular calcium ([Ca2+]i) dynamics in human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) generated from this individual (TECRLHom‐hiPSCs), his heterozygous but clinically asymptomatic father (TECRLHet‐hiPSCs), and a healthy individual (CTRL‐hiPSCs) from the same Sudanese family, revealed smaller [Ca2+]i transient amplitudes as well as elevated diastolic [Ca2+]i in TECRLHom‐hiPSC‐CMs compared with CTRL‐hiPSC‐CMs. The [Ca2+]i transient also rose markedly slower and contained lower sarcoplasmic reticulum (SR) calcium stores, evidenced by the decreased magnitude of caffeine‐induced [Ca2+]i transients. In addition, the decay phase of the [Ca2+]i transient was slower in TECRLHom‐hiPSC‐CMs due to decreased SERCA and NCX activities. Furthermore, TECRLHom‐hiPSC‐CMs showed prolonged action potentials (APs) compared with CTRL‐hiPSC‐CMs. TECRL knockdown in control human embryonic stem cell‐derived CMs (hESC‐CMs) also resulted in significantly longer APs. Moreover, stimulation by noradrenaline (NA) significantly increased the propensity for triggered activity based on delayed afterdepolarizations (DADs) in TECRLHom‐hiPSC‐CMs and treatment with flecainide, a class Ic antiarrhythmic drug, significantly reduced the triggered activity in these cells. In summary, we report that mutations in TECRL are associated with inherited arrhythmias characterized by clinical features of both LQTS and CPVT. Patient‐specific hiPSC‐CMs recapitulated salient features of the clinical phenotype and provide a platform for drug screening evidenced by initial identification of flecainide as a potential therapeutic. These findings have implications for diagnosis and treatment of inherited cardiac arrhythmias.
Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia
Authors: Loke Kah-Yin , Anjian Andrew Sng , Yijuan Yvonne Lim , Ho Wei Li Cindy , Güemes Maria , Hussain Khalid 
Published: October 2016

Summary
Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it’s management is challenging. Diazoxide is the first-line treatment, albeit not all patients will fully respond to it, as episodes of hypoglycaemia may persist and it entails unpleasant adverse effects. Sirolimus, an mTOR inhibitor, has reportedly been successful in treating children with severe diffuse HH, thus obviating the need for pancreatectomy. We report a girl with HH, with a novel heterozygous ABCC8 gene missense mutation (c.4154A>T/ p.Lys1385Thr), who was initially responsive to diazoxide therapy. After 11 months of diazoxide treatment, she developed intermittent, unpredictable breakthrough episodes of hypoglycaemia, in addition to generalized hypertrichosis and weight gain from enforced feeding to avoid hypoglycaemia. Sirolimus, which was commenced at 15 months of age, gradually replaced diazoxide, with significant reduction and abolition of hypoglycaemia. The hypertrichosis resolved and there was less weight gain given the reduced need for enforced feeding. Sirolimus, which was administered over the next 15 months, was well tolerated with no significant side effects and was gradually weaned off. After stopping sirolimus, apart from hypoglycaemia developing during an episode of severe viral gastroenteritis, the capillary glucose concentrations were maintained >3.5 mmol/L, even after a 10 h fast. Sirolimus may have a role in the treatment of partially diazoxide-responsive forms of HH who experience breakthrough hypoglycaemia, but the long-term safety and efficacy of sirolimus are not established.

Learning points:

Conventional treatment of diffuse HH with diazoxide is not always effective in controlling hypoglycaemia and can be associated with unpleasant side effects.
Sirolimus was successfully used to abolish recurrent hypoglycaemia in partially diazoxide-responsive HH, with resolution of unacceptable diazoxide-associated side effects.
Sirolimus was well tolerated with no clinically significant side effects.
Shortly after stopping sirolimus, the capillary glucose levels remained normoglycemic.
Síncope de -N- e -L- intervocálicos no (galego)-português medieval: resultados e cronologias
Authors: S. Pereira Carvalho Maria José 
Published: October 2016

Como é sabido, a síncope de -L- e –N- intervocálicos é um fenómeno exclusivo do galego-português, dentro do quadro das línguas peninsulares. É no sentido de localizar as mudanças linguísticas no tempo, que nos propomos apresentar dados empíricos com vista ao estabelecimento das várias cronologias da eliminação dos encontros vocálicos que decorreram dessa síncope. Organizámos a seguinte tipologia nas terminações com -N-: (i) -ana(s); (ii) -anu/-anos; (iii) -anes; (iv) -ones; (v) -?d?ne(s); (vi) -ag?ne(s); (vii) -?ne(m); -?nes; (viii) -ona;-onu; (ix) -unu; -una; (x) -ena; -enu; (xi) -ene; -enes; (xii) -inu; -ina. Analisámos, igualmente, o modo de resolução dos hiatos após a síncope de consoantes em outros contextos, bem como o plural dos nomes, adjetivos e pronomes, após a síncope de -L-. Os resultados obtidos conduziram à constatação de que no Português da zona Centro-litoral (de onde é oriundo o corpus utilizado) se registaram até ao século XVI os mesmos tratamentos que se registam atualmente nos vários dialetos da Galiza atual. Tais resultados fazem adiar o termo ad quem da unidade linguística galego-portuguesa, no que diz respeito à cronologia deste fenómeno, um dos mais expressivos da história linguística peninsular. Assim, se adotarmos uma perspetiva variacionista, é inevitável considerarmos a existência de um continuum diacrónico e dialetal nesta faixa ocidental, ao longo da história da língua.
Cambio social y reserva de ley
Authors: LORENZ DIETER 
Published: October 2016

<p><strong>I. LA PROBLEMÁTICA</strong><strong></strong></p><p><strong> </strong></p><p>El tema acerca de la relación entre la reserva de ley y el cambio social se encuentra en el punto de intersección entre la protección de los derechos fundamentales y la división de poderes, por una parte, y entre las competencias legislativa y judicial, por otra. El interés sobre dicho tema emana de una perceptible tendencia de la jurisprudencia de exigir en el enjuiciamiento de nuevos desarrollos una reglamentación legal justamente hecha para ellos y, cuando tal reglamentación no exista, de declarar la actuación estatal basada en el derecho presente como ilícita.</p>
Derecho Internacional y desplazamiento forzoso
Authors: NOVOA PARRA MARÍA ESTHER 
Published: October 2016

<p>El artículo comprende una revisión de los antecedentes normativos que regulan actualmente el des- plazamiento forzado en Colombia, a partir de los orígenes de la normatividad internacional de los refugiados, que si bien fue la respuesta a las crisis humanitarias del siglo XX, junto con la Declaración Universal de los Derechos Humanos y el Derecho Internacional Humanitario, constituyen el marco jurídico creado por la comunidad internacional, materializados en los principios rectores de los despla- zamientos internos de 1998 y recogidos por la legislación colombiana en la Ley 387 de 1997.</p><p> </p>Luego de presentar la manera como el Estado colombiano ha venido actuando frente al problema del desplazamiento se concluye que éste no se debilita por la proliferación de normas de carácter asistencial, sino que es necesario tener una política de estado preventiva, a la luz de la realidad socioeconómica, por cuanto sólo de esta manera será posible la prevención del desplazamiento interno y el verdadero respeto a los derechos humanos y al derecho internacional humanitario