bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Kidney Function and in the Rate of Tubular Dysfunction After Tenofovir Withdrawal or Continuation in HIV-Infected Patients
Authors: Casado José L. , del Rey Jose M. , Bañón Sara , Santiuste Carmen , Rodriguez Mar , Moreno Ana , Perez-Elías María J. , Liaño Fernando , Moreno Santiago 
Published: March 2016

Introduction:
Longitudinal data on the changes in kidney function and tubular abnormalities in case of tenofovir disoproxil fumarate (TDF) withdrawal or continuation are scarce.

Methods:
Prospective study of 228 patients receiving TDF, with 3 sequential determinations of serum creatinine, estimated glomerular filtration rate (eGFR), phosphatemia, and different urinary parameters (protein, albumin, phosphaturia, uricosuria, and glycosuria). Changes were analyzed in patients who interrupted TDF as compared to those who continued the same regimen. Proximal renal tubular dysfunction (PRTD) was defined as ≥2 tubular abnormalities.

Results:
After a median follow-up of 59.5 months, 78 patients (34%) had PRTD, mainly proteinuria (40%) and phosphaturia (61%), and time on TDF explains the severity of tubular alterations and eGFR slopes. In 35 switching patients, there was a rapid and significant eGFR improvement (median +4.1 ml/min per 1.73 m2; P = 0.02), leading to a 39%–83% reduction in the prevalence of tubular abnormalities and of PRTD in less than 1 year (66%–39%). In comparison, 193 patients continuing the same regimen for 21.2 months had a small but significant and progressive eGFR decrease (−2.9 mL·min−1·1.73 m−2; P < 0.01), and a progressive rise in the prevalence of phosphaturia, uricosuria, and glycosuria (+9%–56%). In linear mixed-effect model, subsequent eGFR impairment was associated with proteinuria and time on TDF, and eGFR improvement with TDF discontinuation.

Conclusions:
Our data support the role of use and time on TDF in eGFR decline and tubular dysfunction. In contrast, TDF withdrawal is followed by a rapid and significant, although partial, recovery of eGFR and tubular abnormalities.
Demographic and Clinical Profile of Patients With Dementia Receiving Electroconvulsive Therapy
Authors: Zhang Qing-E , Sha Sha , Ungvari Gabor S. , Chiu Helen F.K. , Ng Chee H. , He Hong-Bo , Forester Brent P. , Xiang Yu-Tao 
Published: March 2016

Purpose
Little is known about the clinical characteristics of patients with dementia receiving electroconvulsive therapy (ECT) for the treatment of behavioral symptoms. This study examined the demographic and clinical profile of patients with dementia receiving ECT in China.

Methods
This was a retrospective, case-control study. The sample was composed of 23 patients with dementia treated with ECT and 71 sex- and age-matched controls treated for a period of 8 years (2007–2014) at the National Clinical Research Centre of Mental Disorders, China. Sociodemographic and clinical data were collected from the electronic chart management system.

Results
Multiple logistic regression analysis revealed that ECT was independently associated with high risk for suicide at admission. The recorded indications for ECT included both high risk for suicide and aggressive behavior. Most patients responded to ECT satisfactorily (56.5%) or partially (34.8%) with only mild-moderate transient memory impairment (30.4%).

Conclusions
Although this is a preliminary study limited by the retrospective design and small sample size, findings suggest that ECT is an effective and safe therapeutic intervention to reduce the risk for suicide and aggressive behavior in dementia.
Adaptive significance of quorum sensing-dependent regulation of public goods by integration of growth rate: a trade-off between survival and efficiency
Authors: Nickzad Arvin , Déziel Eric 
Published: March 2016

AbstractQuorum sensing (QS) is a mechanism of communication used by bacteria to monitor cell density and coordinate cooperative behaviors. An emerging framework is that the adaptive significance of QS in regulation of production of costly extracellular metabolites (public goods) is to maintain the homeostasis of cooperation. We investigated the functionality of QS-dependent regulation of rhamnolipids, extracellular surface-active glycolipids promoting the social swarming motility behavior, inBurkholderia glumaeand found that QS is superfluous under rich nutritional conditions. In contrast, decreasing nutrient concentrations to reduce the growth rate amplifies rhamnolipid biosynthesis gene expression, revealing a system where QS-dependent regulation is triggered by the growth rate of the population rather than by its cell density. Our results provide evidence that the adaptive significance of QS in regulation of public goods is to maintain an optimized demand-driven supply of target cooperative behavior, wherein efficiency can be traded off against survival.
Firms’ information system characteristics and management accounting adaptability
Authors: Yigitbasioglu Ogan 
Published: March 2016

Purpose– This study aims to explore the relation between the qualities of the information system (IS), management accounting adaptability (MAA) and its effectiveness.Design/methodology/approach– This study involves the development and empirical testing of a model where the qualities of the IS and management accounting effectiveness (MAE) are mediated by MAA.Findings– Information system flexibility (ISF) and shared knowledge had a significant and positive relation to MAA, which in turn had a positive and significant relation to MAE. There was also a moderation effect of ISF on the relation between IS integration and MAA.Research limitations/implications– IS integration in itself may not lead to management accounting stability, but it is the lack of flexibility of the system and lack of cooperation between the stakeholders that might lead to its stagnation.Practical implications– Organizations are advised to implement solutions that are relatively flexible and modular, as well as encourage cooperation between stakeholders to fully leverage and improve the existing system.Originality/value– The study extends the discourse on the interaction between management accounting and ISs by exploring the role of a number of factors that drive MAA.
Investigating women’s intentions for entrepreneurial growth
Authors: Venugopal Vidhula 
Published: March 2016

Purpose– The purpose of this paper was to investigate the factors affecting the growth intentions of women entrepreneurs in the Indian context.Design/methodology/approach– The author adopted a two-stage design, which included qualitative case studies followed by an online survey of 127 women entrepreneurs.Findings– The findings reinforce the significance of entrepreneurs’ perception of her abilities. They also suggest the changing role of family support in continued entrepreneurship with direct family involvement positively moderating the relationship between attitude to growth and growth intentions.Research limitations/implications– Given the importance of entrepreneurial growth, the findings provide additional insight into growth intentions of women entrepreneurs and also the dynamic role of family in the life cycle of a venture.Originality/value– This paper offers insights into entrepreneurial growth of women in the context of India. It integrates the theory of planned behaviour and social identity theory to provide a comprehensive framework for furthering the understanding of the factors that affect the growth decisions of women entrepreneurs.
The impact of female entrepreneurship on economic growth in Kenya
Authors: Lock Rachel , Lawton Smith Helen 
Published: March 2016

Purpose
– This study aims to provide a better understanding of the barriers and constraints that are faced by women entrepreneurs in starting and running a business in Kenya.

Design/methodology/approach
– The study draws on primary research conducted through face-to-face interviews with female entrepreneurs in Kenya in a wide range of sectors, each having their own micro enterprise. It draws on the framework of Bates et al. (2007) and Baughn et al. (2006) to look at the entrepreneurship landscape in Kenya and the barriers and constraints faced by women entrepreneurs, as well as the support and opportunities available.

Findings
– It was found that female entrepreneurs in Kenya face far fewer barriers to starting micro-enterprises now than ever before. It is proving to be a widely successful model, which they use to lift themselves and their families out of poverty. There remain, however, a number of barriers to growth within the micro-enterprise sector. On the basis of these, the paper argues that for female entrepreneurship to have a greater impact on economic growth within Kenya, the country needs to introduce more effective policies, regulation of the informal sector and further support to women entrepreneurs. For example, support could take the form of business training, mentoring and financial support.

Originality/value
– The paper presents original research on the growing phenomenon of female entrepreneurship in Kenya as a means of alleviating poverty. It considers how this trend relates to the growing availability of microfinance.
The impact of person-organization fit on innovative work behavior
Authors: Afsar Bilal 
Published: March 2016

Purpose– The direct relationship between person-organization (P-O) fit and employee’s positive work attitudes and behaviours have been well researched. However, there has been no study on the impact of P-O fit on innovative work behaviour (IWB) of the nurses. The purpose of this paper is to fill this gap in the literature. In order to give a complete understanding of the psychology surrounding P-O fit, this study has longitudinally analysed the relationship between P-O fit and IWB along with the impact of a potential mediator, i.e. knowledge sharing behaviour (KSB) on this relationship.Design/methodology/approach– A total of 357 nurses and 71 doctors from three government hospitals of Thailand filled out the questionnaires. Structural equation modelling was used to analyse the relationships.Findings– Results of the study indicate that a nurse’s P-O fit is positively associated with both self and doctor ratings of innovative behaviours; and KSB acts as a partial mediator between P-O fit and IWB at both Times 1 and 2. These results imply that a nurse’s perceived fit in the hospital impacts his/her engagement into IWB. As nurses share knowledge with their co-workers frequently, it tends to strengthen the relationship between P-O fit and IWB.Originality/value– Study findings begin to explain how P-O fit impacts IWB of nurses. Specifically, the author find that KSB explains the relationship between P-O fit and IWB.
Advancing the Big Five of user-oriented care and accounting for its variations
Authors: Kajonius Petri , Kazemi Ali 
Published: March 2016

Purpose
– Care process quality (i.e. how care is enacted by a care worker toward a client at the interpersonal level) is a strong predictor of satisfaction in a wide range of health care services. The purpose of this paper is to describe the basic elements of care process quality as user-oriented care. Specifically, the questions of how and why quality in user-oriented care varies were investigated in the context of elderly care.

Design/methodology/approach
– Two municipalities were selected for in-depth field studies. First, in each municipality, the authors interviewed and observed care workers’ interactions with the older persons in both home care and nursing homes during two weeks (Study 1). Second, in an attempt to gain a deeper understanding of why process quality in terms of user-oriented care varies, the authors conducted interviews with care workers and care unit managers (Study 2).

Findings
– A new taxonomy for categorizing process quality variation, the Big Five of user-oriented care (task-focus, person-focus, affect, cooperation, and time-use), is proposed. In addition, the perceived reasons for process quality variation are reported in our own developed Quality Agents Model, suggesting that variations in care process evaluations may be explained from different perspectives at multiple levels (i.e., older person, care worker-, unit-, department-, and municipality level).

Originality/value
– The proposed taxonomy and model are useful for describing user-oriented care quality and the reasons for its variations. These findings are of relevance for future quality developments of elderly care services, but also may be adapted to applications in any other enterprise employing a user-oriented approach.
Five focus strategies to organize health care delivery
Authors: Peltokorpi Antti , Linna Miika , Malmström Tomi , Torkki Paulus , Lillrank Paul Martin 
Published: March 2016

Purpose– The focused factory is one of the concepts that decision-makers have adopted for improving health care delivery. However, disorganized definitions of focus have led to findings that cannot be utilized systematically. The purpose of this paper is to discuss strategic options to focus health care operations.Design/methodology/approach– First the literature on focus in health care is reviewed revealing conceptual challenges. Second, a definition of focus in terms of demand and requisite variety is defined, and the mechanisms of focus are explicated. A classification of five focus strategies that follow the original idea to reduce variety in products and markets is presented. Finally, the paper examines managerial possibilities linked to the focus strategies.Findings– The paper proposes a framework of five customer-oriented focus strategies which aim at reducing variety in different characteristics of care pathways: population; urgency and severity; illnesses and symptoms; care practices and processes; and care outcomes.Research limitations/implications– Empirical research is needed to evaluate the costs and benefits of the five strategies and about system-level effects of focused units on competition and coordination.Practical implications– Focus is an enabling condition that needs to be exploited using specific demand and supply management practices. It is essential to understand how focus mechanisms differ between strategies, and to select focus that fits with organization’s strategy and key performance indicators.Originality/value– Compared to previous more resource-oriented approaches, this study provides theoretically solid and practically relevant customer-oriented framework for focusing in health care.
Performance management of the public healthcare services in Ireland: a review
Authors: Mesabbah Mohammed , Arisha Amr 
Published: March 2016

Purpose
– Performance Management (PM) processes have become a potent part of strategic and service quality decisions in healthcare organisations. In 2005, the management of public healthcare in Ireland was amalgamated into a single integrated management body, named the Health Service Executive (HSE). Since then, the HSE has come up with a range of strategies for healthcare developments and reforms, and has developed a PM system as part of its strategic planning. The purpose of this paper is to review the application of PM in the Irish Healthcare system, with a particular focus on Irish Hospitals and Emergency Services.

Design/methodology/approach
– An extensive review of relevant HSE’s publications from 2005 to 2013 is conducted. Studies of the relevant literature related to the application of PM and of international best practices in healthcare performance systems are also presented.

Findings
– PM and performance measurement systems used by the HSE include many performance reports designed to monitor performance trends and strategic goals. Issues in the current PM system include inconsistency of measures and performance reporting, unclear strategy alignment, and deficiencies in reporting (e.g. feedback and corrective actions). Furthermore, PM processes have not been linked adequately into Irish public hospitals’ management systems.

Research limitations/implications
– The HSE delivers several services such as mental health, social inclusion, etc. This study focuses on the HSE’s PM framework, with a particular interest in acute hospitals and emergency services.

Originality/value
– This is the first comprehensive review of Irish healthcare PM since the introduction of the HSE. A critical analysis of the HSE reports identifies the shortcomings in its current PM system.
Relative position fitting based control strategy for thruster point assembly mechanism of electric propulsion
Authors: Li Xiaohui , Geng Jie , Zhang Qiang , Sun Jing 
Published: March 2016

Purpose
– Thruster point assembly mechanism (TPAM) of the electric propulsion system allows to adjust the thrust vector, so that the thrust vector is directed to the satellite center of gravity (COG) during the satellite on-orbit working period. In this way the impact of disturbance torque caused by deviation of the thrust vector from the satellite COG during thruster ignition can be decreased. Therefore, the control accuracy of satellite is influenced directly by the control accuracy of TPAM. On the other hand, the on-orbit application of TPAM is restricted to the on-orbit computer resource. Therefore, the purpose of this paper is to design a control strategy for TPAM, and the strategy should not only be able to control the TPAM precisely but also be easily implemented by the on-board computer.

Design/methodology/approach
– First, the structure and work principle of TPAM are discussed, and the mathematical model based on D-H coordinate system is built for it. Then the fitting methods are utilized to design the control strategy of TPAM. Absolute position fitting-based control strategy and relative position fitting-based control strategy are designed, and the least squares algorithm is introduced for parameter selection.

Findings
– Simulations and tests are provided for the TPAM. Compared with the state-of-the-art PD controller, the proposed control strategy shows smaller overshoot and more simple realization. The experiment results are matched with the simulation results and both the experiment and simulation results show the validity of the proposed control strategies.

Practical implications
– The designed control strategies can be used for the TPAM of some satellite’s electric propulsion system.

Originality/value
– The mathematical model of the TPAM based on D-H coordinate system is given. The absolute position fitting-based control strategy and relative position fitting-based control strategy are proposed. Compared with existing methods, the two control strategies have more simple structure and smaller amount of computations. Furthermore, the relative position fitting-based control strategy achieves high precision with simple structure.
Upper limb bilateral symmetric training with robotic assistance and clinical outcomes for stroke
Authors: Simkins Matt , Byl Nancy , Kim Hyunchul , Abrams Gary , Rosen Jacob 
Published: March 2016

Purpose
– The purpose of this paper is to evaluate the physiotherapeutic benefits of bilateral symmetric training (BST) for stroke survivors affected by hemiparesis.

Design/methodology/approach
– Other studies have investigated symmetric physiotherapy. A key difficulty in previous work is in maintaining mirror-imaged trajectories between the affected and less-affected limbs. This obstacle was overcome in this work by using a two-armed robotic exoskeleton to enforce symmetry. In total, 15 subjects,
>
6 months post stroke were, randomly assigned to bilateral symmetric robotic training, unilateral robotic training, and standard physical therapy.

Findings
– After 12 training sessions (90 minutes/session), the bilateral training group had the greatest intensity of movement training. They also had the greatest improvement in range of motion at the shoulder. The unilateral training group showed the greatest reduction in spasticity.

Research limitations/implications
– The rationale for symmetric physiotherapy is that it might promote connections from the undamaged brain hemisphere. The robot generated copious amounts of detailed kinematic data. Even though these data provided insights into the human to machine interface using different training modalities, it proved difficult to draw neurological conclusions. It is recommended that future research along these lines should include measures of neurophysiological change and/or changes in neurological activity.

Practical implications
– This research suggests that the advantage of bilateral symmetric movement over other modalities is slight, and that robotic training has comparable results with standard care. If BST is used, care is potentially needed to avoid exacerbation of spasticity. Finally, this research includes a novel quantitative approach for evaluating robotic training.

Originality/value
– This study is of value to therapeutic researchers interested in new physiotherapy techniques, roboticists interested in developing rehabilitation devices, or for rehabilitation game designers interested in using virtual reality.
Performance evaluation of mobile communication system with reliability measures
Authors: Ram Mangey , Nagiya Kuldeep 
Published: March 2016

Purpose
– The purpose of this paper is to evaluate performance of mobile communication system with reliability measures.

Design/methodology/approach
– The mobile communication system consists of a mobile station (MS), base transceiver station (BTS), base station controller (BSC) and the mobile switching center. The MS is connected to BTS, BTS is connected to BSC and BSC is connected with the mobile switching system. With the help of these stations working, the authors have developed a mathematical model using Markovian approach.

Findings
– Using the supplementary variable technique, the Laplace transformations and Markov process theory, the reliability indices of the mobile communication system are determined.

Originality/value
– In the present work, the authors have developed a mathematical model based on a mobile communication system.
Future urban design strategies for health and wellbeing
Authors: Shiue Ivy 
Published: March 2016

Purpose– Contemporary urban design has tried to account for the satisfaction of the human experience and climate change which might encompass several disciplines. However, from a methodological perspective, a systematic research approach is still lacking. Therefore, this paper aims to propose a universal research method embedded into early urban design phase with an example.Design/methodology/approach– A case study was used under the concept of DIDID Action Plan, which was proposed to integrate systematic research into urban design projects in the early phase with a focus on health and well-being. Moreover, design mapping skills tackling health risks at the population level were discussed.Findings– This proposal of DIDID Action Plan has provided inclusive steps for future urban design projects with a systematic approach, in particular for health and well-being aspect. DIDID denotes five planning stages, namely, dream, initiation, design, implementation and delivering. With the advancement of urbanisation and technology, more emphasis would be placed on health and well-being to delay chronic diseases by targeting risk contributors and to increase citizens’ quality of life and human life experience, although stopping the breakout of unexpected communicable diseases and disasters would also need to be considered from time to time as well.Practical implications– Systematic research to be integrated into early urban design phase could potentially avoid issues such as re-design and save manpower time and costs.Originality/value– This proposal is the first to provide a universal research method for early urban design phase with a focus on health and well-being.