bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetric Diels–Alder Cycloadditions of Trifluoromethylated Dienophiles Under Trienamine Catalysis
Authors: Yuan Xin , Zhang Shan‐Jun , Du Wei , Chen Ying‐Chun 
Published: June 2016

Abstractβ‐Trifluoromethyl (CF3) enones were proved to act as good dienophiles in asymmetric normal‐electron‐demand Diels–Alder cycloadditions with 2,4‐dienals under trienamine catalysis with a chiral secondary amine. The sequential reductive amination transformations with benzylamine produced cis‐ and trans‐fused chiral trifluoromethylated octahydroisoquinolines in a diastereodivergent manner by using NaBH(OAc)3 and NaBH3CN as the reductants, respectively. Moreover, other types of activated alkenes that bear a CF3 group have also been successfully utilized to construct a diverse range of chiral cyclic frameworks in high stereoselectivity.
Rationalization of the Color Properties of Fluorescein in the Solid State: A Combined Computational and Experimental Study
Authors: Arhangelskis Mihails , Eddleston Mark D. , Reid David G. , Day Graeme M. , Bučar Dejan‐Krešimir , Morris Andrew J. , Jones William 
Published: June 2016

AbstractFluorescein is known to exist in three tautomeric forms defined as quinoid, zwitterionic, and lactoid. In the solid state, the quinoid and zwitterionic forms give rise to red and yellow materials, respectively. The lactoid form has not been crystallized pure, although its cocrystal and solvate forms exhibit colors ranging from yellow to green. An explanation for the observed colors of the crystals is found using a combination of UV/Vis spectroscopy and plane‐wave DFT calculations. The role of cocrystal coformers in modifying crystal color is also established. Several new crystal structures are determined using a combination of X‐ray and electron diffraction, solid‐state NMR spectroscopy, and crystal structure prediction (CSP). The protocol presented herein may be used to predict color properties of materials prior to their synthesis.
Magnesium Lewis Acid Assisted Oxidative Bromoetherification Involving Bromine Transfer from Alkyl Bromides with Aldehydes by Umpolung of Bromide
Authors: Moriyama Katsuhiko , Nishinohara Chihiro , Togo Hideo 
Published: June 2016

AbstractAn oxidative bromoetherification involving a bromine transfer from alkyl bromides upon reacting them with aldehydes in a Grignard reaction with a concurrent oxidation of bromide was developed to provide substituted tetrahydrofurans in high yields. This reaction, which proceeds through two types of bromine transfer, was promoted by the addition of a Brønsted acid. Mechanistic studies suggested that a magnesium Lewis acid activates hypobromate, which is generated in situ from the reaction of bromide and Oxone to improve the electrophilicity of the bromonium ion (Br+) for the oxidative bromoetherification of alkenyl alcohols. Furthermore, the magnesium Lewis acid catalyzed oxidative bromoetherification of an alkenyl alcohol proceeded to provide a cyclization product in 92 % yield.
Self‐Immolative Linkers as Caps for the Design of Gated Silica Mesoporous Supports
Authors: Juárez L. Alberto , Añón Elena , Giménez Cristina , Sancenón Félix , Martínez‐Máñez Ramón , Costero Ana M. , Gaviña Pablo , Parra Margarita , Bernardos Andrea 
Published: June 2016

AbstractA new hybrid material based on sulforhodamine B dye‐loaded silica mesoporous nanoparticles capped with a self‐immolative gate has been synthesized and characterized. The gated material's controlled release behavior is monitored under different pH conditions. Under acidic and neutral conditions, a low level of dye release is detected. However, at slightly basic pH, significant dye release occurs owing to deprotonation of the phenol moiety in the capping molecule, which results in its disassembly.
Synthesis of 2‐Alkynoates by Palladium(II)‐Catalyzed Oxidative Carbonylation of Terminal Alkynes and Alcohols
Authors: Cao Qun , Hughes N. Louise , Muldoon Mark J. 
Published: June 2016

AbstractA homogeneous PdII catalyst, utilizing a simple and inexpensive amine ligand (TMEDA), allows 2‐alkynoates to be prepared in high yields by an oxidative carbonylation of terminal alkynes and alcohols. The catalyst system overcomes many of the limitations of previous palladium carbonylation catalysts. It has an increased substrate scope, avoids large excesses of alcohol substrate and uses a desirable solvent. The catalyst employs oxygen as the terminal oxidant and can be operated under safer gas mixtures.
Label‐Free Detection of Glycan–Protein Interactions for Array Development by Surface‐Enhanced Raman Spectroscopy (SERS)
Authors: Li Xiuru , Martin Sharon J. H. , Chinoy Zoeisha S. , Liu Lin , Rittgers Brandon , Dluhy Richard A. , Boons Geert‐Jan 
Published: June 2016

AbstractA glyco‐array platform has been developed, in which glycans are attached to plasmonic nanoparticles through strain‐promoted azide‐alkyne cycloaddition. Glycan–protein binding events can then be detected in a label‐free manner employing surface‐enhanced Raman spectroscopy (SERS). As proof of concept, we have analyzed the binding of Gal1, Gal3, and influenza hemagglutinins (HAs) to various glycans and demonstrated that binding partners can be identified with high confidence. The attraction of SERS for optical sensing is that it can provide unique spectral signatures for glycan–protein complexes, confirm identity through statistical validation, and minimizes false positive results common to indirect methods. Furthermore, SERS is very sensitive and has multiplexing capabilities thereby allowing the simultaneous detection of multiple analytes.
ChemInform Abstract: A Molten Salt Lithium—Oxygen Battery.
Authors: Giordani Vincent , Tozier Dylan , Tan Hongjin , Burke Colin M. , Gallant Betar M. , Uddin Jasim , Greer Julia R. , McCloskey Bryan D. , Chase Gregory V. , Addison Dan 
Published: June 2016

AbstractA Li/O2 battery using a Li anode, molten LiNO3—KNO3 or LiNO3—KNO2—CsNO3 eutectic electrolytes, and a porous carbon O2 cathode at 120—150 °C exhibits high energy efficiency of about 95% and improved rate capability.
ChemInform Abstract: A One‐Dimensional Polyoxomolybdate Polymer as a Catalyst for the Epoxidation of Olefins.
Authors: Najafi M. , Abbasi A. , Masteri‐Farahani M. , Shahbaazi H. , Ahmadniai Motlagh M. , Janczak J. 
Published: June 2016

AbstractThe one‐dimensional coordination polymer {(NH4)4Mo8O26}n is hydrothermally synthesized from an aqueous mixture of (NH4)6Mo7O24, ZnCl2, HCl, and terephthalic acid (autoclave, 140 °C, 4 d).
ChemInform Abstract: Layered Perovskite Oxychloride Bi4NbO8Cl: A Stable Visible Light Responsive Photocatalyst for Water Splitting.
Authors: Fujito Hironori , Kunioku Hironobu , Kato Daichi , Suzuki Hajime , Higashi Masanobu , Kageyama Hiroshi , Abe Ryu 
Published: June 2016

AbstractThe title material is prepared by solid state reaction of a stoichiometric mixture of Bi2O3, BiOCl, and Nb2O5 (evacuated silica tube, 1173 K, 20 h) and characterized by powder XRD and UV/VIS diffuse reflectance spectroscopy.
ChemInform Abstract: Face‐Shared Octahedral Dimer In2O7S2 in the Non‐Centrosymmetric Barium Indiumsilicate Oxysulfide Ba2In2Si3O10S.
Authors: Guo Wei‐Huan , Jiang Xiao‐Ming , Liu Bin‐Wen , Wu Jia‐Wei , Li Shu‐Fang , Zeng Hui‐Yi , Guo Guo‐Cong , Huang Jin‐Shun 
Published: June 2016

AbstractSingle crystals of the new title compound are obtained from an alkali polychalcogenide flux consisting of K2S, S, In, SiO2, and BaCl2 in a molar ratio of 2:2:4:1:4 (evacuated quartz tubes, 1.
ChemInform Abstract: Copper(I) Chloride Promoted C(sp2)—N Cross‐Coupling of 1,2‐Di(pyrimidin‐2‐yl) Disulfides with Amines: An Efficient Approach to Obtain C2‐Amino Functionalized Pyrimidines.
Authors: Wei Kai‐Jie , Quan Zheng‐jun , Zhang Zhang , Da Yu‐xia , Wang Xi‐cun 
Published: June 2016

AbstractA protocol for chemoselective transformation of disulfides into aryl and alkyl amines is developed.
ChemInform Abstract: Engaging Alkenyl Halides with Alkylsilicates via Photoredox Dual Catalysis.
Authors: Patel Niki R. , Kelly Christopher B. , Jouffroy Matthieu , Molander Gary A. 
Published: June 2016

AbstractAmmonium organobis(catecholato)silicates, serving as radical precursors, and alkenyl halides are cross‐coupled via dual photoredox/Ni catalysis.
ChemInform Abstract: Selective N‐Acetylation of Aromatic Amines Using Acetonitrile as Acylating Agent.
Authors: Saikia Ujwal Pratim , Hussain Farhaz L. , Suri Mrinaly , Pahari Pallab 
Published: June 2016

AbstractThe new method for the N‐acetylation of aromatic amines uses acetonitrile as an acylating agent and in situ generated trimethylsilyl iodide as the catalyst under microwave irradiation.
ChemInform Abstract: Enhancement of N‐Heterocyclic Carbenes on Rhodium Catalyzed Olefination of Triazoles.
Authors: Zhao Shixian , Wu Feifei , Ma Yuyu , Chen Wanzhi , Liu Miaochang , Wu Huayue 
Published: June 2016

AbstractUsing carbene transfer reactions, four new rhodium complexes of N‐heterocyclic carbenes, e.g. RHC, are prepared.
ChemInform Abstract: Metal‐Free Intermolecular Hydrophenoxylation of Aryl Alkynes.
Authors: Patel Monika , Saunthwal Rakesh K. , Dhaked Devendra K. , Bharatam Prasad V. , Verma Akhilesh K. 
Published: June 2016

AbstractTerminal as well as internal alkynes react with phenols and alkanols in an anti‐Markovnikov fashion giving β‐arylvinyl ethers in good yields with excellent Z selectivity.
ChemInform Abstract: A Route to α‐Fluoroalkyl Sulfides from α‐Fluorodiaroylmethanes.
Authors: Lin Ya‐mei , Yi Wen‐bin , Shen Wan‐zhao , Lu Guo‐ping 
Published: June 2016

Abstractα,α‐Difluorodiarylmethanes are successfully used as nucleophilic difluoromethylation reagents to generate α‐thioaryl‐α,α‐difluoroacetophenones or difluoromethylthiolated arenes from disulfides under transition‐metal free conditions.
ChemInform Abstract: Graphene Oxide Catalyzed C—H Bond Activation: The Importance of Oxygen Functional Groups for Biaryl Construction.
Authors: Gao Yongjun , Tang Pei , Zhou Hu , Zhang Wei , Yang Hanjun , Yan Ning , Hu Gang , Mei Donghai , Wang Jianguo , Ma Ding 
Published: June 2016

AbstractThe oxygen sites in the graphene oxide catalyst and the addition of potassium tert‐butoxide are found to be essential for this novel direct C—H arylation method.
ChemInform Abstract: Gold‐Catalyzed Intramolecular Cyclizations of Cyclopropenes with Propargylic Esters.
Authors: Zhu Peng‐Long , Tang Xiang‐Ying , Shi Min 
Published: June 2016

AbstractA gold‐catalyzed intramolecular cycloisomerization of cyclopropenes, N‐ or O‐tethered, affords 5‐azaspiro[2.5]oct‐7‐enes and bicyclo[4.1.0]heptanes depending on the substitution pattern.
ChemInform Abstract: Catalytic Oxidative Coupling of Primary Amines under Air: A Flexible Route to Benzimidazole Derivatives.
Authors: Nguyen Khac Minh Huy , Largeron Martine 
Published: June 2016

AbstractIn a bioinspired approach, the cooperative action of cupric bromide as electron‐transfer mediator and a topaquinone‐like co‐catalyst is studied.
ChemInform Abstract: 4‐Aryl‐NH‐1,2,3‐triazoles via Multicomponent Reaction of Aldehydes, Nitroalkanes, and Sodium Azide.
Authors: Wu Luyong , Wang Xianghui , Chen Yuxue , Huang Qinglan , Lin Qiang , Wu Mingshu 
Published: June 2016

AbstractThis novel approach to the title compounds works well with aromatic aldehydes only: cinnamaldehyde and octanal do not react while phenylglyoxal hydrate (VI) gives 4‐phenyl‐1,2,3‐triazole (IIIa) in low yield only.
ChemInform Abstract: Application of Novel Multi‐Cationic Ionic Liquids in Microwave Assisted 2‐Amino‐4H‐chromene Synthesis.
Authors: Kumbhar Arjun , Jadhav Sanjay , Shejwal Rajendra , Rashinkar Gajanan , Salunkhe Rajshri 
Published: June 2016

AbstractThe newly prepared ionic liquid (CIL) is used for the microwave‐assisted multicomponent cyclocondensation of naphthols with aromatic aldehydes and malononitrile to give aminochromenes.
ChemInform Abstract: 1,1′‐Carbonyldiimidazole (CDI) Mediated Coupling and Cyclization to Generate [1,2,4]Triazolo[4,3‐a]pyridines.
Authors: Baucom Kyle D. , Jones Sian C. , Roberts Scott W. 
Published: June 2016

AbstractA CDI mediated coupling of 2‐pyridylhydrazines and carboxylic acids followed by cyclization reaction to generate [1,2,4]triazolo[4,3‐a]pyridines is reported.
ChemInform Abstract: One‐Pot, Highly Efficient, Asymmetric Synthesis of Ring‐Fused Piperidine Derivatives Bearing N,O‐ or N,N‐Acetal Moieties.
Authors: Li Ji‐Yao , Li Zhi‐Long , Zhao Wei‐Wei , Liu Yan‐Kai , Tong Zhi‐Ping , Tan Rui 
Published: June 2016

AbstractThis stereoselective method relies on an organo‐catalyzed asymmetric Diels—Alder reaction/iminium ion‐induced cyclization sequence.
ChemInform Abstract: The Base‐Promoted Synthesis of Multisubstituted Benzo[b][1,4]oxazepines.
Authors: Shen Jinhai , Xue Lulu , Lin Xing , Cheng Guolin , Cui Xiuling 
Published: June 2016

AbstractReaction conditions are optimized for the base promoted cyclization of N‐(2‐haloaryl)enaminones which offer a simple access to substituted benzo[b][1,4]oxazepines in moderate to good yields.
ChemInform Abstract: A Versatile One‐Pot Strategy for the Synthesis of [1,4]Thiazepino[5,4‐a]isoquinolines Containing Intramolecular Hydrogen Bonds.
Authors: Alizadeh Abdolali , Bayat Fahimeh , Zhu Zhe 
Published: June 2016

AbstractThe title compounds are constructed via a sequential 4‐component domino reaction from phenacylbromides, isoquinoline, aryl isothiocyanates and DMAD in good yields.
ChemInform Abstract: Highly Efficient Solvent Free Synthesis of α‐Aminophosphonates Catalyzed by Recyclable Nano‐Magnetic Sulfated Zirconia (Fe3O4@ZrO2/SO42‐).
Authors: Ghafuri Hossein , Rashidizadeh Afsaneh , Esmaili Zand Hamid Reza 
Published: June 2016

AbstractAn environmentally benign method for preparation of the aminophosphonates via Kabachnik—Fields reaction using sulfated zirconia supported on magnetic nanoparticles is developed.
ChemInform Abstract: Lanostane‐Type Triterpenes from the Fungal Endophyte Scleroderma UFSMSc1 (Persoon) Fries.
Authors: Morandini Liziane M.B. , Neto Alexandre T. , Pedroso Marcelo , Antoniolli Zaida I. , Burrow Robert A. , Bortoluzzi Adailton J. , Mostardeiro Marco A. , da Silva Ubiratan F. , Dalcol Ionara I. , Morel Ademir F. 
Published: June 2016

AbstractTwo lanostane triterpenoids, sclerodol A (Ia) and B (Ib), are isolated from the culture of Eucalyptus grandis derived from the endophyte Scleroderma UFSMSc1 (Persoon) Fries.
ChemInform Abstract: A New Concept for Electroless Nickel Plating: Aluminum as Reducing Agent.
Authors: Zhang Xingkai , Zhang Junyan 
Published: June 2016

AbstractNickel coatings on Cu substrates are obtained using plating baths containing only NiSO4, ammonia, and an Al foil connected to the Cu substrate that serves as the electron source for Ni deposition (20 °C, 30 min).
ChemInform Abstract: Interactions Between Lasers and Two‐Dimensional Transition Metal Dichalcogenides
Authors: Lu Junpeng , Liu Hongwei , Tok Eng Soon , Sow Chorng‐Haur 
Published: June 2016

AbstractReview: focus on the use of laser‐based technologies as effective tools for the characterization, modification, and manipulation of transition metal dichalcogenides; 113 refs.
ChemInform Abstract: Marine‐Derived Myxobacteria of the Suborder Nannocystineae: An Underexplored Source of Structurally Intriguing and Biologically Active Metabolites
Authors: Davila‐Cespedes Antonio , Hufendiek Peter , Cruesemann Max , Schaeberle Till F. , Koenig Gabriele M. 
Published: June 2016

AbstractReview: [85 refs.
Visualisierung der DNA‐Doppelhelixstruktur mit einfachen Mitteln
Authors: Quadbeck‐Seeger Hans‐Jürgen 
Published: June 2016

AbstractDie Doppelhelix der DNA ist zur Ikone der modernen Biologie und der Medizin geworden. Inzwischen begegnen uns ständig Abbildungen dieser molekularen Struktur. Dabei handelt es sich in der Regel um die B‐Form der DNA, die in der Natur vorherrscht und um die es auch in diesem Artikel geht. Es ist allerdings erstaunlich, wie oft deren Darstellungen falsch sind oder Unzutreffendes andeuten.
On the effect of temperature on precipitation and aggregation of asphaltenes in light live oils
Authors: Mohammadi Saber , Rashidi Fariborz , Mousavi‐Dehghani Sayed Ali , Ghazanfari Mohammad‐Hossein 
Published: June 2016

AbstractAsphaltene precipitation and deposition is a serious issue in all facets of petroleum production and processing. Despite the numerous experimental efforts concerning asphaltenes, the effect of temperature on asphaltene precipitation and aggregation in live oils remains an elusive and controversial subject in the available literature. In this work, a series of high pressure‐high temperature depressurization experiments were designed to assess the effect of temperature on asphaltene precipitation and aggregation in light live oils. Asphaltene related experiments were performed using a high pressure microscope and high pressure‐high temperature filtration setup on a light live oil with a low asphaltene content and a high potential of asphaltene formation. The results of the experiments were interpreted in terms of asphaltene onset pressure, size distribution and average diameter of the aggregates, fractal dimension of the asphaltene aggregates, and the amount of precipitated asphaltene. It was found that the depressurization process at higher temperatures resulted in higher asphaltene onset pressure or earlier formation of asphaltenes. Visualization experiments showed that asphaltene aggregates in light live oil are pressure‐temperature fractal structures. The depressurization process at lower temperatures led to the formation of highly porous and loose aggregate structures with relatively low fractal dimensions. As the temperature of the depressurization process decreases, the mechanism of asphaltene aggregation changes gradually from reaction‐limited aggregation to diffusion‐limited aggregation. This research reveals that temperature has crucial effects on the asphaltene aggregation process in light live oils at elevated pressures, which is of great importance for asphaltene handling and separation.
Synthesis of Highly Stable Porous Metal‐Iminodiacetic Acid Gels from A Novel IDA Compound
Authors: Chen Wenjing , Jiang Yanhong , Ding Xuesong , Yan Chaoguo , Han Baohang 
Published: June 2016

AbstractIn this work, a novel and simple flexible aromatic multi‐carboxylate compound N,N′‐(4,4′‐biphenylyl) iminodiacetic acid (BP‐IDA) was synthesized, with which two new stable metal‐IDA gels (denoted as MIG1 and MIG2) with three‐dimensional network structures have been prepared successfully by employing Cr3+ and Al3+ as the metal ions, respectively. The rheological performance was investigated by means of dynamic rheology measurement. The morphology and microstructure were characterized by scanning electron microscopy, transmission electron microscopy, and X‐ray diffraction technique. Nitrogen sorption isotherm measurement suggests that the MIG1 aerogel has considerable porosity with the Brunauer‐Emmett‐Teller specific surface area up to 760 m2·g−1. Owing to easy preparation, good stability, and three‐dimensional network structure, the as‐prepared metal‐organic gels will possess potential applications in separation, catalysis, and drug delivery.
Recent Progress in the Application of Polyoxometalates for Dye‐sensitized/Organic Solar Cells
Authors: Ye Tengling , Wang Junhai , Dong Guohua , Jiang Yanxia , Feng Chen , Yang Yulin 
Published: June 2016

AbstractAt present, high efficiency and low fabrication cost are still the main goal that people pursuit for next‐generation solar cells such as dye‐sensitized solar cells (DSSCs) and organic solar cells (OPVs). Polyoxometalates (POMs), as an environmentally friendly material, are a type of stable, low cost and soluble oxide clusters with desirable features, including highly tunable structural properties, peculiar optoelectronic properties and excellent redox properties. Thus, during the recent years, POMs have been increasingly recognized as important building blocks for DSSCs and OPVs. In this review, the development of various molecular and hybrid materials derived from POMs is discussed with regard to the function in solar cells.
Discovery of New Potential Anti‐Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target‐Focused Repurposing Approaches
Authors: Annunziato Giannamaria , Angeli Andrea , D'Alba Francesca , Bruno Agostino , Pieroni Marco , Vullo Daniela , De Luca Viviana , Capasso Clemente , Supuran Claudiu T. , Costantino Gabriele 
Published: June 2016

AbstractIn academia, compound recycling represents an alternative drug discovery strategy to identify new pharmaceutical targets from a library of chemical compounds available in house. Herein we report the application of a rational target‐based drug‐repurposing approach to find diverse applications for our in‐house collection of compounds. The carbonic anhydrase (CA, EC 4.2.1.1) metalloenzyme superfamily was identified as a potential target of our compounds. The combination of a thoroughly validated docking screening protocol, together with in vitro assays against various CA families and isoforms, allowed us to identify two unprecedented chemotypes as CA inhibitors. The identified compounds have the capacity to preferentially bind pathogenic (bacterial/protozoan) CAs over human isoforms and represent excellent hits for further optimization in hit‐to‐lead campaigns.
Longitudinal analysis of patient‐reported outcomes and cosmesis in a randomized trial of conventionally fractionated versus hypofractionated whole‐breast irradiation
Authors: Swanick Cameron W. , Lei Xiudong , Shaitelman Simona F. , Schlembach Pamela J. , Bloom Elizabeth S. , Fingeret Michelle C. , Strom Eric A. , Tereffe Welela , Woodward Wendy A. , Stauder Michael C. , Dvorak Tomas , Thompson Alastair M. , Buchholz Thomas A. , Smith Benjamin D. 
Published: June 2016

BACKGROUNDThe authors compared longitudinal patient‐reported outcomes and physician‐rated cosmesis with conventionally fractionated whole‐breast irradiation (CF‐WBI) versus hypofractionated whole‐breast irradiation (HF‐WBI) within the context of a randomized trial.METHODSFrom 2011 to 2014, a total of 287 women with American Joint Committee on Cancer stage 0 to stage II breast cancer were randomized to receive CF‐WBI (at a dose of 50 grays in 25 fractions plus a tumor bed boost) or HF‐WBI (at a dose of 42.56 grays in 16 fractions plus a tumor bed boost) after breast‐conserving surgery. Patient‐reported outcomes were assessed using the Breast Cancer Treatment Outcome Scale (BCTOS), the Functional Assessment of Cancer Therapy‐Breast, and the Body Image Scale and were recorded at baseline and 0.5, 1, 2, and 3 years after radiotherapy. Physician‐rated cosmesis was assessed at the same time points. Outcomes by treatment arm were compared at each time point using a 2‐sided Student t test. Multivariable mixed effects growth curve models assessed the effects of treatment arm and time on longitudinal outcomes.RESULTSOf the 287 patients enrolled, 149 were randomized to CF‐WBI and 138 were randomized to HF‐WBI. At 2 years, the Functional Assessment of Cancer Therapy‐Breast Trial Outcome Index score was found to be modestly better in the HF‐WBI arm (mean 79.6 vs 75.9 for CF‐WBI; P = .02). In multivariable mixed effects models, treatment arm was not found to be associated with longitudinal outcomes after adjusting for time and baseline outcome measures (P≥.14). The linear effect of time was significant for BCTOS measures of functional status (P = .001, improved with time) and breast pain (P = .002, improved with time).CONCLUSIONSIn this randomized trial, longitudinal outcomes did not appear to differ by treatment arm. Patient‐reported functional and pain outcomes improved over time. These findings are relevant when counseling patients regarding decisions concerning radiotherapy. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2886–2894. © 2016 American Cancer Society