bluuebunny/crossref_metadata_2025_split huggingface dataset:
Az új orális antikoagulánsokkal történő kezelés laboratóriumi vonatkozásai
Authors: Bereczky Zsuzsanna , Oláh Zsolt , Ajzner Éva , Kappelmayer János 
Published: December 2017

Abstract: The introduction of novel oral anticoagulants (NOAC) have long been expected drugs and they quickly became used widespread as their clinical effectiveness was as good as, or even better than the previously used only oral anticoagulant drug, the coumarins. Thus, the direct thrombin inhibitor dabigatran and the activated factor X inhibitors (rivaroxaban, apixaban, edoxaban) have become the part of daily therapeutic practice. Their permeation was facilitated by the guideline which suggested that no laboratory monitoring was required during NOAC treatment and this was very convenient for both patients and doctors. The clinical experience obtained in the past years, however have proved that the ‘one size fits all’ view is oversimplified and there are numerous situations when the determination NOAC levels is unavoidable or highly recommended. This review discusses the laboratory aspects of NOAC treatment, primarily summarizing their effect on the screening tests and special assays of hemostasis and we also describe the correct methods to determine their plasma concentrations. Orv Hetil. 2017; 158(49): 1930–1945.
Experimental study on the dynamic response of a gravity dam model with longitudinal joints
Authors: Tan Lili , Hu Xiao 
Published: December 2017

A shaking table model test is conducted to study the dynamic response and failure mode of a 185 m high concrete gravity dam with longitudinal joints. Two longitudinal joints are provided in the dam model. A mortar mixture is used as the model material to satisfy the similarity requirements for the model test. The dynamic response and damage process of the dam are observed by inputting earthquake excitations with different ground peak accelerations (GPAs) and durations. It is observed that when the GPA is 5·32g (equivalent to 0·4g on the prototype) and the duration is 3·2 s, a crack appears at the top of the longitudinal joint that is close to the reservoir side and then extends to the slope of the downstream face. After 6·4 s, this joint is totally pulled apart and meets the crack that was previously formed. This study shows that when a strong earthquake occurs, the top of the longitudinal joint of the dam is more likely to suffer tensile damage, and the longitudinal joint will open because of the relatively low tensile strength. Based on the variations in strains, acceleration responses and dynamic characteristics, the possible crack location and damage process of the dam can be predicted.
АДАПТИВНАЯ МОДЕЛЬ БИНАРНОГО ВЫБОРА И ВОЗМОЖНОСТИ ЕЕ ПРАКТИЧЕСКОГО ИСПОЛЬЗОВАНИЯ
Authors: Davnis V. V. , Yurova Y. A. 
Published: December 2017

Цель: построение адаптивной модели бинарного выбора на основе нового подхода к реализации адаптивных принципов. Обсуждение: принципы адаптации, перекочевав из живой природы в науку, технику, теорию и практику управления, показывают абсолютную универсальность. Трудно назвать область человеческой деятельности, в которой эти принципы нельзя было бы использовать. Особое место они занимают в моделировании экономических процессов. Механизм, с помощью которого осуществляется практическая реализация принципов адаптации, основан на экспоненциальном сглаживании. Процедура экспоненциального сглаживания оказалась столь удачной, что ее использовали даже при объяснении смысла гипотезы адаптивных ожиданий. В результате применения этой процедуры происходит затухание более ранних тенденций и закономерностей, что естественным образом обеспечивает доминирование закономерностей, демонстрируемых последними наблюдениями. Возникает закономерный вопрос: действительно ли процедура экспоненциального сглаживания представляет собой единственный способ, с помощью которого удается осуществить плавную замену старых тенденций новыми. В исследовании предлагается не затухание более ранних тенденций, а усиление вновь нарождающихся. Понятно, что усиление новых тенденций автоматически приводит к относительному снижению значимости старых. Фактически достигается тот же самый эффект. Результаты: предлагаемый способ построения адаптивного механизма назван степенным сглаживанием, что, по мнению авторов, подчеркивает аналогичность его предназначенности с экспоненциальным сглаживанием. Но в отличие от экспоненциального сглаживания степенное сглаживание применяется для построения нелинейных регрессионных моделей, коэффициенты которых оцениваются с помощью метода максимального правдоподобия, специфика которого учитывается экспоненциальным сглаживанием. Изложены детали применения этого подхода дял построения адаптивной модели бинарного выбора.
The Effect of Polysaccharides Peptides Ganoderma Lucidum to Aortic Foam Cell Count and Lipid Profile in Type 2 Diabetic Model Rattus Norvegicus Strain Wistar
Authors: Sargowo Djanggan , Wihastuti Titin Andri , Sukotjo Cathrine Theodora , Anjani Prasanti Mahesa , Handayani Olivia , Adrian Liemena Harold 
Published: December 2017

BACKGROUND: Type 2 Diabetes Mellitus (DM) is one of dominant factors in cardiovascular deaths and induces endothelial dysfunction. A definite sign of endothelial dysfunction is foam cells formation derived from oxidized LDL. This study was conducted to determine effect of Polysaccharides Peptides (PsP) Ganoderma lucidum to foam cell counts and lipid profile in diabetic model rats with high-fat diet.METHODS: Treatment group was categorized to negative control, positive control, DM-50, DM-150, and DM-300. Type 2 DM induced by Streptozotocin. PsP is administered with predetermined doses on each treatment’s group (50, 150, and 300 mg/kgBW) for 12 weeks. Measurements of foam cell count were held after obtaining rat’s aorta. To assess lipid profile, blood sample was taken from the rat's heart. Data analyzed by One-way ANOVA and Post Hoc Tukey tests.RESULTS: The administration of Ganoderma lucidum PsP to diabetic model rats provided a significant difference in lowering foam cell (p=0.017; CI 95%). It also gave significant difference between levels of each lipid components (Total Cholesterol, Trygliceride, LDL and HDL) in at least two treatment groups (p=0.010; CI 95%). Based on Post Hoc Tukey tests, the relationship between administration of PsP and foam cell is significant (p=0.002).CONCLUSION: PsP has antioxidant and anti-inflammatory effect in type 2 DM model Rattus norvegicus strain wistar, which can inhibit atherosclerosis and endothelial damage process. Further studies are necessary to evaluate the benefits of PsP as an adjuvant therapy in management of diabetic dyslipidemia.KEYWORDS: PsP, Ganoderma lucidum, foam cell, lipid profile, DM
Telomeres and Telomerase in The Aging Heart
Authors: Meiliana Anna , Dewi Nurrani Mustika , Wijaya Andi 
Published: December 2017

BACKGROUND: Aging per se is a risk factor for reduced cardiac function and heart diseases, even when adjusted for aging-associated cardiovascular risk factors. Accordingly, aging-related biochemical and cell-biological changes lead to pathophysiological conditions, especially reduced heart function and heart disease.CONTENT: Telomere dysfunction induces a profound p53-dependent repression of the master regulators of mitochondrial biogenesis and function, peroxisome proliferator-activated receptor gamma coactivator (PGC)-1a and PGC-1b in the heart, which leads to bioenergetic compromise due to impaired oxidative phosphorylation and ATP generation. This telomere-p53-PGC mitochondrial/metabolic axis integrates many factors linked to heart aging including increased DNA damage, p53 activation, mitochondrial, and metabolic dysfunction and provides a molecular basis of how dysfunctional telomeres can compromise cardiomyocytes and stem cell compartments in the heart to precipitate cardiac aging.SUMMARY: The aging myocardium with telomere shortening and accumulation of senescent cells restricts the tissue regenerative ability, which contributes to systolic or diastolic heart failure. Moreover, patients with ion-channel defects might have genetic imbalance caused by oxidative stress-related accelerated telomere shortening, which may subsequently cause sudden cardiac death. Telomere length can serve as a marker for the biological status of previous cell divisions and DNA damage with inflammation and oxidative stress. It can be integrated into current risk prediction and stratification models for cardiovascular diseases and can be used in precise personalized treatments.KEYWORDS: aging, telomere, telomerase, aging heart, mitochondria, cardiac stem cell
Pensamiento pedagógico colombiano: Martín Restrepo Mejía. Una mirada a sus conceptos de pedagogía, infancia, maestro y escuela
Authors: Jiménez Becerra Absalon 
Published: December 2017

El artículo se enmarca en el inicio de una línea de investigación: Historia del pensamiento pedagógico colombiano. Esta propuesta busca rescatar el trabajo de una serie de intelectuales de la educación, quienes, por medio de sus razonamientos, intervenciones, conferencias, ensayos, y libros han aportado al ejercicio reflexivo de la educación local y regional. Esta primera investigación rescata la vida y obra de uno de los primeros intelectuales de la educación colombiana; Martín Restrepo Mejía (1865-1935). Se enfatiza especialmente en sus reflexiones y representaciones de la pedagogía, la infancia, el maestro, y la educación escolar.
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Contextualización Idioma Maya Kaqchikel
Contextualizadora: Myrna Lucy Xajpot Sanain
Ministerio de Educación de Guatemala
RUK’U’X SAMAJ

Re jun peraj samaj re ntikir rikin rucholajem rukanoxik na'oj: Rutzijol ch’ob’onïk pa ruwi rub’eyal tijonïk richin colombiano. Re jun na’oj re’ nrajo chi nikol ri kina’oj ri yalan yechobon pa ruwi’ tijonïk, ruma nkiya’ kina’oj chupan ri kitzijonïk, ri kisamaj, ri kitz’ib’anik nkiya’ richin yoj ch’ob’on pa ruwi’ tijonïk pa taq kitinamit akuchi e k’owi’. Chupam re jun nab’ey na’oj re, xkikanöj rukolik k’ik’aslem ri nab’ey taq chob’onela’ pa ruwi ri tijonïk richin ri tinamït Colombia; Martín Restrepo Mejía (1865-1935). Janta pe niya’ox runataxik chupam kich’ob’oj chuqa’ toq yech’o pa ruwi’ rub’eyal tijonïk, pa kiwi’ ri ak’wala’, pa kiwi’ ri tijonela’, chuqa’ ri tijonïk pa tijob’äl jay.
Ruk’u’x tan tzij: na’oj richin rub’eyal tijojïk; rub’eyal tijonïk; pa kiwi’ ak’wala’; pa kiwi’ tijonela’; chupam ri tijob’äl; Na’oj samaj tijonela’ Hisula.
Enhancement of Regeneration Efficiency through Callus Induction Media Using 2,4-Dicholorophenoxyacetic acid in Indica Rice (Oryza sativa L. var. Ciherang)
Authors: Azizah Kunti Anis , Restanto Didik Pudji , Sugiharto Bambang 
Published: December 2017

Indica rice variety Ciherang is the most planted variety in Indonesia, but the micropropagation technique is restricted because it is known has low regeneration frequency and included as recalcitrant cultivar for tissue culture and tranformation activities. One of solution to resolve that problem is developing a technique of somatic embryogenesis in callus of ciherang rice cultivar. The aims of study were to determine medium composition for inducting embryogenic callus in Ciherang rice and to know the effectivity of rice regeneration using callus as explant. The methods were included induction of embryogenic callus in callus induction media (CIM) containing MS basal, Proline 600 mg/l, Casein Hidrolisat 300 mg/l, phytagel 2,5 g/l, BAP 0.25 mg/l, sukrosa 30 %, and 2,4-D in different concentration, from 2,4-D 0 mg/l as control (CIM 1), 2,4-D 2 mg/l (CIM 2), 2,4-D 3 mg/l (CIM 3), and 2,4-D 4 mg/l (CIM 4). It then be continued to regenerate the calli in RM 1 medium containing MS basal, NAA 0,2 mg/l, Kinetin 2 mg/l, Agarose 10 g/l, and sukrosa 30 %, pH 5,8 for six days in dark and RM2 medium containing MS basal , NAA 0,2 mg/l, Kinetin 2 mg/l, Agarose 8 g/l, sukrosa 30 %, pH 5,8 in light room. Results showed CIM 4 medium using 2,4-D 4 mg/l gave optimum result in calli induction with procentage 57,63% and CIM 3 using 2,4-D 3 mg/l gave optimum result in embryonic calli induction with procentage 53,63%. Result of embryonic calli gave regeneration frequency procentage is 9,6%. The total planlet obtained after five weeks old in regeneration medum were 11 planlets ready for aclimatization.
Keywords: Somatic embryo, Indica rice (Oryza sativa L. var. Ciherang), Callus
Combination of Organic Fertilizer and Biological Agent for Pest Control Spodoptera exigua of Plant Onion in Gending, Probolinggo
Authors: Agustini Yusia , Purwatiningsih P. , Sulistyanto Didik 
Published: December 2017

Onion is one of lowland vegetables commodity that has been long cultivated intensively by farmers in Indonesia. Probolinggo is one of the regions which give considerable contribution of producing onion to the national needs. In an effort to increase production, onion farmers in Probolinggo mostly relies on external supply in the form of artificial chemicals (fertilizers and pesticides). However, the using of artificial chemicals can cause pollution and damage the environment. So that utilization of biological agents and organic fertilizers which are environmentally friendly can become other solutions to increase the yield of onion production. Based on this case, it is very important in efforts to increase production of onion by combining organic fertilizers to enrich the content of organic matter in the soil with biological agents in tackling pests attack. Based on the research results in application of combining organic fertilizers granules plus NEP and biological agents Heterorhabditis sp. in District Gending Probolinggo shows that : 1. reducing the population of pests Spodoptera exigua up to 72.260%. 2. improving onion plant growth more optimal. From the result, it shows that the combination of organic fertilizer granule plus biological agents and NEP Heterorhabditis sp. (P2A1) is more effective than the combination of the others.
Keywords: onion, biological agents, spodoptera exigua
Diversity and Density Gastropods in Mangrove Forest of Si Runtoh Beach, Baluran National Park
Authors: Siwi Fitri Retnananing , Sudarmadji S. , Suratno S. 
Published: December 2017

The mangrove forest is one of the coastal ecosystems of unique and productive. One of the animals that can be found in the mangrove ecosystem are gastropods. Gastropods constitute the largest class of the phylum of mollusks. Gastropods can usually be found in tidal areas, because these animals have a very high adaptability. The existence of mangrove gastropods in the area can be used as an indicator that the mangrove on the beach working properly or not. Diversity and density of research conducted in the mangrove forest Si Beach Runtoh Baluran National Park in February until April 2014 during a low tide maximal. The sampling method used in this research is the method of transects made per station. Transect length is 100 m, the total number of stations is 8, and the distance between the station 25 m. In one station consists of 8 transects, transects 15 m spacing, each transect consists of three plots measuring 5 m x 5 m. The results showed a diversity of mangrove Gastropods Si Beach Runtoh Baluran National Park is H '= 4,180 were classified as moderate while gastropods density obtained is 0.832 individu/m2.
Keywords: gastropods, diversity, density
ANALISIS KESEDIAAN MEMBAYAR (WILLINGNESS TO PAY) BERAS CERDAS CV AN – NAHLAH DI KABUPATEN JEMBER
Authors: Rahayu Anggraini Dwi , Hapsari Triana Dewi , Adam Julian 
Published: December 2017

This study was aimed to identify : (1) consumer characteristic related to their willingness to pay for beras cerdas CV An – Nahlah in Jember ; (2) maximum average willingness to pay of beras cerdas CV An – Nahlah consumer in Jember ; (3) factors affecting consumer willingness to pay for beras cerdas CV An – Nahlah in Jember. The method used is analytical descriptive method. Sample taken purposively using incidental sampling technique. The data analyzed using descriptive analysis and multiple linier regression. The study showed that (1) the characteristics of beras cerdas CV An – Nahlah consumer was related to their willingness to pay are; female, has a bachelor degree, include in adult group, married employed, average income Rp 1.500.000 – Rp 3.000.000 monthly their willingness to pay ranged between Rp 17.001 – Rp 21.000 per 800 gram. (2) maximum average consumer willingness to pay is Rp 20.075 per 800 gram. (3) factors influenced consumer willingness to pay are; age, gender, married status, education, job, and monthly income.
A Constituição, as instituições e as delegações legislativas: um caso de mutação
Authors: Cyrino André Rodrigues , Nunes Daniel Capecchi 
Published: December 2017

A hipótese do presente artigo é a de que as delegações legislativas fazem parte da realidade brasileira pós-1988, sendo compatíveis com a democracia e admitidas pelo Texto Constitucional, cujos sentidos passaram por um processo de mutação. Para comprová-la, o artigo percorrerá três etapas. Na primeira parte, será exposta a interpretação tradicional da doutrina que advoga a impossibilidade das delegações legislativas, no regime da Constituição de 1988, com base no artigo 25 do ADCT e suas limitações empíricas e normativas. Em seguida, na segunda parte, o leitor será apresentado ao conceito de mutação constitucional. Por fim, na terceira e última parte, demonstraremos como o surgimento de delegação legislativas no regime constitucional brasileiro se deu pela via de uma mutação, consubstanciada na atuação dos três Poderes. O trabalho se encerra com uma breve conclusão.
Análise das Capacidades de Programas de Pós-Graduação da Área de ACT: um enfoque em Mestrados Profissionais
Authors: Souza Maria Clara Martins de , Oliveira Murilo Alvarenga 
Published: December 2017

Há um crescimento significativo dos programas de mestrado profissional em administração (MPA) no Brasil. A área de Administração, Ciências Contábeis e Turismo da Capes tem apresentado um crescimento significativo dos cursos de mestrado profissional, 65% de aumento enquanto os programas acadêmicos cresceram 15% no triênio de 2013. Para que os programas possam responder aos desafios do novo contexto econômico, social e tecnológico e se manterem atuantes é necessário que estejam dotados de uma gestão eficiente. Dessa forma, o objetivo desta pesquisa é analisar os MPAs eficientes em busca das capacidades que os tornam eficientes. As capacidades identificadas serão relacionadas por meio de um modelo de capacidades de inovação. Para isso, foi realizada análise DEA de forma a identificar os programas eficientes e uma análise de conteúdo das propostas destes programas que estão dispostas na plataforma Sucupira para identificar como estes programas alcançam tal eficiência. Por meio de um modelo adaptado, analisou-se o processo de determinação de MPAs eficientes e suas capacidades. Como resultado, foi possível identificar algumas das principais capacidades que levam um programa a ser eficiente, dentre elas a capacidade de inserção social. O estudo colabora para que outros MPAs consigam, por meio do modelo proposto, fazer uma análise autoanálise, identificando quesitos precisam ser aprimorados e, por meio deste estudo, encontrar caminhos para elaboração de estratégias que são utilizadas pelos programas considerados eficientes.
Alkalic Leaching and Stabilization of Arsenic from Pyrite Cinders
Authors: Wang Yongliang , Xiao Li , Liu Ya , Fu Guoyan , Ye Shufeng , Chen Yunfa 
Published: December 2017

Introduction:
Pyrite cinder is one of the important secondary resources, but typically contains a certain amount of arsenic, which is harmful to metallurgical process. It usually hopes to remove the arsenic prior to recycle the valuable element in the pyrite cinders.

Methods & Materials:
In this study, the arsenic in the cinders was selectively removed using the alkalic leaching method so as to reduce the loss of ferric and other valuable elements.

Results & Discussion:
The content of arsenic in pyrite cinders was reduced to 0.08% through the investigation of the factors, including particle size, alkaline concentration, temperature, solid-liquid ratio (S/L) and leaching time. Then, the ferric precipitation method was used to remove the arsenic in the leaching solution. More than 99% of the arsenic can be removed by controlling the pH and the ratio of ferric and arsenic (Fe/As) in ambient temperature, and the arsenic concentration in the solution was reduced to less than 0.5mg/L.

Conclusion:
It was found that the precipitated arsenic was mainly amorphous based on the analysis of sediment.
SCREENING OF TEN HERBAL EXTRACTS TO COMPARE AND INVESTIGATE EFFECT ON GLUCOSE LOWERING AND ANOREXIC ACTIVITY IN WISTAR RATS
Authors: Jani Deepti Kaushalkumar , Goswami Sunita 
Published: December 2017

Objective: Metabolic disorders are of growing concern with increasing quest for herbal medicines as treatment option. The current study is planned to screen ten herbal extracts, prepared from parts of chosen six herbal plants, to compare and investigate their antihyperglycemic and anorexic potential.Methods: Qualitative phytochemical investigation was done as per standard procedures. Acute oral toxicity study performed as per OECD 420 guideline. Glucose Tolerance Test (method optimization) was performed to select appropriate glucose load to induce hyperglycemia. Antihyperglycemic activity was evaluated by Glucose Tolerance Test (single dose and multiple dose study) and anorexic potential was screened by food intake measurement using Wistar rats.Results: All herbs were found safe in acute oral toxicity study. Glucose Tolerance Test method optimization study signaled use of 3 g/kg glucose load for induction of hyperglycemia in single and multiple dose studies. In single dose study, L. acutangula fruit extract and in multiple dose study, S. melongena, M. oleifera & R. communis extracts were found to produce significant glucose lowering effect as compared to glucose control group. Results of food intake measurement showed significant appetite suppression with extracts of W. somnifera, S. melongena, M. oleifera & R. communis. Conclusion: Present study throws light on the effectiveness of experimental herbal extracts as antihyperglycemic and anorexic agents. This also, helps in identifying potent indigenous herbs for further study.
INFLUÊNCIA DE FATORES SOCIOECONÔMICOS E CLÍNICOS NA QUALIDADE DE VIDA DE HIPERTENSOS
Authors: Fernandes Darci Ramos , Rocha Tânia Pavão Oliveira , Santos Edenilde Alves , Figueiredo Neto José Albuquerque , Santana Ewaldo Éder Carvalho , Lima Rafael de Abreu 
Published: December 2017

A hipertensão arterial é considerada um problema grave de saúde pública no Brasil e no mundo devido às altas cargas de doenças representadas pela morbimortalidade, podendo influenciar na qualidade de vida. O objetivo do estudo foi analisar a influência de fatores socioeconômicos e clínicos na qualidade de vida de hipertensos atendidos na Estratégia Saúde da Família em São Luís, Maranhão, Brasil. O método adotado foi o estudo transversal e observacional, conduzido em amostra representativa de 502 hipertensos. Os dados foram coletados por meio de questionário de caracterização socioeconômica e clínica. Para avaliação da qualidade de vida utilizaram-se os questionários SF-36 e MINICHAL, comparando-os. Os dados foram analisados por meio de testes de Mann-Witney, Kruskall-Wallis, Bonferroni e Dunnet. Os resultados indicaram que os hipertensos do sexo feminino, idade > 60 anos, solteiros/separados/viúvos, baixa escolaridade, aposentados que continuavam na ativa, baixa renda, níveis pressóricos não controlados, tempo diagnóstico > 10 anos, presença de diabetes, sobrepeso e obesidade, sedentarismo e tabagismos apresentaram menores escores de qualidade de vida. Concluiu-se que o conhecimento dos fatores socioeconômicos e clínicos são determinantes na qualidade de vida dos hipertensos e podem favorecer o planejamento adequado das ações de saúde para melhor atender a esse segmento crescente da população.
Palavras-chave: Hipertensão. Fatores socioeconômicos. Qualidade de vida. Estratégia Saúde da Família.