bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endovascular thrombectomy with or without systemic thrombolysis?
Authors: Tsivgoulis Georgios , Katsanos Aristeidis H. , Mavridis Dimitris , Alexandrov Anne W. , Magoufis Georgios , Arthur Adam , Caso Valeria , Schellinger Peter D. , Alexandrov Andrei V. 
Published: January 2017

Objectives: Current recommendations advocate that pretreatment with intravenous thrombolysis (IVT) should first be offered to all eligible patients with emergent large vessel occlusion (ELVO) before an endovascular thrombectomy (ET) procedure. However, there are observational data that question the safety and efficacy of IVT pretreatment in patients with ELVO. Methods: We performed a meta-analysis of the included subgroups from ET randomized controlled trials (RCTs) to evaluate the comparative efficacy between direct ET without IVT pretreatment and bridging therapy (IVT and ET) in patients with ELVO. Results: We included a total of seven RCTs, including 1764 patients with ELVO (52.8% men). Patients receiving bridging therapy (IVT followed by ET) had lower rates ( p = 0.041) of 90-day death/severe dependency (modified Rankin Scale-score of 5–6; 19.0%, 95% CI: 14.1–25.1%) compared with patients receiving only ET (31.0%, 95% CI: 21.2–42.9%). Moreover, patients receiving IVT and ET had a nonsignificant ( p = 0.389) trend towards higher 90-day functional independence rates (51.4%, 95% CI: 42.5–60.1%) compared with patients undergoing only ET (41.7%, 95% CI: 24.1–61.7%). Finally, shift-analysis uncovered a nonsignificant trend towards functional improvement at 90 days for bridging therapy over ET (cOR = 1.28, 95% CI: 0.91–1.89; p = 0.155). It should be noted that patients included in the present meta-analysis were not randomized to receive IVT, and thus the two groups (bridging therapy versus ET monotherapy) may differ in terms of baseline characteristics and, in particular, in terms of onset to groin puncture time and thus the risk of confounding bias cannot be ruled out. Conclusion: Despite the limitations and the risk of confounding bias, our findings contradict the recent notion regarding potential equality between ET and bridging therapy in ELVO patients and suggest that IVT and ET are complementary therapies that should be pursued in a parallel and noncompeting fashion.
Dependency and health utilities in stroke: Data to inform cost-effectiveness analyses
Authors: Ali Myzoon , MacIsaac Rachael , Quinn Terence J , Bath Philip M , Veenstra David L , Xu Yaping , Brady Marian C , Patel Anita , Lees Kennedy R 
Published: January 2017

Introduction Health utilities (HU) assign preference weights to specific health states and are required for cost-effectiveness analyses. Existing HU for stroke inadequately reflect the spectrum of post-stroke disability. Using international stroke trial data, we calculated HU stratified by disability to improve precision in future cost-effectiveness analyses. Materials and methods We used European Quality of Life Score (EQ-5D-3L) data from the Virtual International Stroke Trials Archive (VISTA) to calculate HU, stratified by modified Rankin Scale scores (mRS) at 3 months. We applied published value sets to generate HU, and validated these using ordinary least squares regression, adjusting for age and baseline National Institutes of Health Stroke Scale (NIHSS) scores. Results We included 3858 patients with acute ischemic stroke in our analysis (mean age: 67.5 ± 12.5, baseline NIHSS: 12 ± 5). We derived HU using value sets from 13 countries and observed significant international variation in HU distributions (Wilcoxon signed-rank test p < 0.0001, compared with UK values). For mRS = 0, mean HU ranged from 0.88 to 0.95; for mRS = 5, mean HU ranged from −0.48 to 0.22. OLS regression generated comparable HU (for mRS = 0, HU ranged from 0.9 to 0.95; for mRS = 5, HU ranged from −0.33 to 0.15). Patients’ mRS scores at 3 months accounted for 65–71% of variation in the generated HU. Conclusion We have generated HU stratified by dependency level, using a common trial endpoint, and describing expected variability when applying diverse value sets to an international population. These will improve future cost-effectiveness analyses. However, care should be taken to select appropriate value sets.
Understanding the relationship between costs and the modified Rankin Scale: A systematic review, multidisciplinary consensus and recommendations for future studies
Authors: Wilson Alastair , Bath Philip MW , Berge Eivind , Cadilhac Dominique A , Cuche Matthieu , Ford Gary A , Macisaac Rachael , Quinn Terence J , Taylor Matthew , Walters Matthew , Wolff Claudia , Lees Kennedy R ,   for the ESO-VISTA Health Economics Working Group
Published: January 2017

Background and purpose Cost-of-illness studies often describe a single aggregate cost of a disease state. This approach is less helpful for a condition with a spectrum of outcomes like stroke. The modified Rankin Scale is the most commonly used outcome measure for stroke. We sought to describe the existing evidence on the costs of stroke according to individual modified Rankin Scale categories. This may be useful in future cost effectiveness modelling studies of interventions where cost data have not been collected, but disability outcome is known. Methods Systematic review of the published literature, searching electronic databases between 2004 and 2015 using validated search filters. Results were screened to identify studies presenting costs by individual modified Rankin Scale categories. Results Of 17,782 unique identified articles, 13 matched all inclusion criteria. In only four of these studies were costs reported by modified Rankin Scale categories. Most studies included direct medical costs only. Societal costs were assessed in two studies. Overall, studies had a high methodological and reporting quality. The heterogeneity in costing methods used in the identified studies prevented meaningful comparison of the reported cost data. Despite this limitation, the costs consistently increased with greater severity (increasing modified Rankin Scale score). Conclusions Few cost studies of stroke include information based on stroke recovery measured by individual modified Rankin Scale categories and the existing data are limited. To reliably capture this information, future studies are needed that preferably apply standardised costing methods to promote greater potential for use in cost-effectiveness analyses whereby direct collection of patient-level resource use has not been possible.
Diagnosis of primary ciliary dyskinesia: potential options for resource-limited countries
Authors: Rumman Nisreen , Jackson Claire , Collins Samuel , Goggin Patricia , Coles Janice , Lucas Jane S. 
Published: January 2017

Primary ciliary dyskinesia is a genetic disease of ciliary function leading to chronic upper and lower respiratory tract symptoms. The diagnosis is frequently overlooked because the symptoms are nonspecific and the knowledge about the disease in the primary care setting is poor. Additionally, none of the available tests is accurate enough to be used in isolation. These tests are expensive, and need sophisticated equipment and expertise to analyse and interpret results; diagnosis is therefore only available at highly specialised centres. The diagnosis is particularly challenging in countries with limited resources due to the lack of such costly equipment and expertise.In this review, we discuss the importance of early and accurate diagnosis especially for countries where the disease is clinically prevalent but diagnostic tests are lacking. We review the diagnostic tests available in specialised centres (nasal nitric oxide, high-speed video microscopy, transmission electron microscopy, immunofluorescence and genetics). We then consider modifications that might be considered in less well-resourced countries whilst maintaining acceptable accuracy.
RETRACTED ARTICLE: The gastro protective effects of Cibotium barometz hair on ethanol-induced gastric ulcer in Sprague-Dawley rats
Authors: AL-Wajeeh Nahla Saeed , Hajerezaie Maryam , Noor Suzita Mohd , Halabi Mohammed Farouq , Al-Henhena Nawal , Azizan Ainnul Hamidah Syahadah , Kamran Sareh , Hassandarvish Pouya , Shwter Abdrabuh N. , karimian Hamed , Ali Hapipah Mohd , Abdulla Mahmood Ameen 
Published: January 2017

Abstract
Background
Cibotium barometz is a medical herb used traditionally in the Malaysian peninsula for several ailments, including gastric ulcer. The aim of this study was assessment the anti-ulcer effects of C. barometz hair on ethanol-induced stomach hemorrhagic abrasions in animals. Seven groups of Sprague Dawley (SD) rats were administered 10% Tween 20 in the normal control and ulcer control groups, and omeprazole 20 mg/kg and 62.5, 125, 250, and 500 mg/kg of C. barometz hair extract in the experimental groups. After 60 min, the normal control group of rats was orally administered 10% Tween 20, while absolute ethanol was orally administered to the groups of ulcer control, omeprazole and experimental groups. Stomachs of the rats were examined macroscopically and histologically. Homogenates of stomachs were used to evaluate endogenous antioxidant enzyme activities.

Results
Rats pre-fed with plant extract presented a significant decrease in the sore area, increased pH of gastric contents and preserved stomach wall mucus compared to the ulcer group. Histologically, rats pre-fed with C. barometz hair extract showed mild to moderate disruptions of the surface epithelium while animals pre-fed with absolute ethanol showed severe disruptions of the stomach epithelium with edema and leucocyte penetration of the submucosal layer. A Periodic acid Schiff (PAS) staining revealed that each rat pre-treated with the plant extract displayed an intense uptake of stomach epithelial glycoprotein magenta color compared to the ulcer control group. Immunohistochemical analysis revealed that rats pre-fed with the plant extract showed an up-regulation of the heat shock protein 70 (HSP70) and down-regulation of Bax proteins compared to ulcer control rats. Homogenates of the stomach tissue demonstrated significant increases in the endogenous antioxidant enzymatic activity and decreased lipid peroxidation (MDA) in rats pre-treated with C. barometz hair extract compared with the ulcer control rats. In acute toxicity, the liver and kidney revealed no hepatotoxic or nephrotoxic effects histologically.

Conclusions
The gastric cytoprotective action of C. barometz hair extract might be attributed to antioxidants, an increase in gastric pH, stomach mucus preservation, increased endogenous antioxidant enzymes, decreased lipid peroxidation, up-regulation of HSP70 and down-regulation of Bax proteins.
Coherence in Hong Lou Meng and its English translations: an exploratory investigation
Authors: Li Xi , Wu Canzhong 
Published: January 2017

AbstractCoherence can be studied from both logical and textual perspectives in systemic functional linguistics. The logical and textual metafunctions together contribute to the coherence of a text. Coherence is realized through clause complexes and cohesive chains at the lexicogrammatical level from the logical and textual meanings. Clause complex reflects the logical development of the text, while cohesive chains are the threads of a coherent text. The clauses that are involved in cohesive chains take a more important role in forming a coherent text than others, and thus have the potential to reveal the features of coherence realization.This research aims to explore the realization of coherence in a Chinese novelHong Lou Mengand its two English translations,The Dream of the Red Mansions(by Yang Xianyi and Gladys Yang) andThe Story of the Stone(by David Hawkes), or more specifically, the distribution of logico-semantic types in both the Chinese (ST) and the English texts (TT). The research shows that there are both similarities and differences between the ST and the TTs on the one hand, and between the TTs on the other, and that the differences are related to the styles of translators.
Systematic evaluation of markers used for the identification of human induced pluripotent stem cells
Authors: Bharathan Sumitha Prameela , Manian Kannan Vrindavan , Aalam Syed Mohammed Musheer , Palani Dhavapriya , Deshpande Prashant Ajit , Pratheesh Mankuzhy Damodaran , Srivastava Alok , Velayudhan Shaji Ramachandran 
Published: January 2017

ABSTRACTLow efficiency of somatic cell reprogramming and heterogeneity among human induced pluripotent stem cells (hiPSCs) demand extensive characterization of isolated clones before their use in downstream applications. By monitoring human fibroblasts undergoing reprogramming for their morphological changes and expression of fibroblast (CD13), pluripotency markers (SSEA-4 and TRA-1-60) and a retrovirally expressed red fluorescent protein (RV-RFP), we compared the efficiency of these features to identify bona fide hiPSC colonies. The co-expression kinetics of fibroblast and pluripotency markers in the cells being reprogrammed and the emerging colonies revealed the heterogeneity within SSEA-4+ and TRA-1-60+ cells, and the inadequacy of these commonly used pluripotency markers for the identification of bona fide hiPSC colonies. The characteristic morphological changes in the emerging hiPSC colonies derived from fibroblasts expressing RV-RFP showed a good correlation between hiPSC morphology acquisition and silencing of RV-RFP and facilitated the easy identification of hiPSCs. The kinetics of retroviral silencing and pluripotency marker expression in emerging colonies suggested that combining both these markers could demarcate the stages of reprogramming with better precision than with pluripotency markers alone. Our results clearly demonstrate that the pluripotency markers that are routinely analyzed for the characterization of established iPSC colonies are not suitable for the isolation of pluripotent cells in the early stages of reprogramming, and silencing of retrovirally expressed reporter genes helps in the identification of colonies that have attained a pluripotent state and the morphology of human embryonic stem cells (hESCs).
A phantom study for ground-glass nodule detectability using chest digital tomosynthesis with iterative reconstruction algorithm by ten observers: association with radiation dose and nodular characteristics
Authors: Miyata Katsunori , Nagatani Yukihiro , Ikeda Mitsuru , Takahashi Masashi , Nitta Norihisa , Matsuo Satoru , Ohta Shinichi , Otani Hideji , Nitta-Seko Ayumi , Murakami Yoko , Tsuchiya Keiko , Inoue Akitoshi , Misaki Sayaka , Erdenee Khishigdorj , Kida Tetsuo , Murata Kiyoshi 
Published: January 2017

Objective:
To compare detectability of simulated ground-glass nodules (GGNs) on chest digital tomosynthesis (CDT) among 12 images obtained at 6 radiation doses using 2 reconstruction algorithms and to analyze its association with nodular size and density.

Methods:
74 simulated GGNs [5, 8 and 10 mm in diameter/−630 and −800 Hounsfield units (HU) in density] were placed in a chest phantom in 14 nodular distribution patterns. 12 sets of coronal images were obtained using CDT at 6 radiation doses: 120 kV–10 mA/20 mA/80 mA/160 mA, 100 kV–80 mA and 80 kV–320 mA with and without iterative reconstruction (IR). 10 radiologists recorded GGN presence and locations by continuously distributed rating. GGN detectability was compared by receiver operating characteristic analysis among 12 images and detection sensitivities (DS) were compared among 12 images in subgroups classified by nodular diameters and densities.

Results:
GGN detectability at 120 kV–160 mA with IR was similar to that at 120 kV–80 mA with IR (0.614 mSv), as area under receiver operating characteristic curve was 0.798 ± 0.024 and 0.788 ± 0.025, respectively, and higher than six images acquired at 120 kV (p &lt; 0.05). For nodules of −630 HU/8 mm, DS at 120 kV–10 mA without IR was 73.5 ± 6.0% and was similar to that by the other 11 data acquisition methods (p = 0.157). For nodules of −800 HU/10 mm, DS both at 120 kV–80 mA and 120 kV–160 mA without IR was improved by IR (56.3 ± 11.9%) (p &lt; 0.05).

Conclusion:
CDT demonstrated sufficient detectability for larger more-attenuated GGNs (&gt;8 mm) even in the lowest radiation dose (0.17 mSv) and improved detectability for less-attenuated GGNs with the diameter of 10 mm at submillisievert with IR.

Advances in knowledge:
IR improved detectability for larger less-attenuated simulated GGNs on CDT.
Reducing the mast vibration of single-mast stacker cranes by gain-scheduled control
Authors: Hajdu Sándor , Gáspár Péter 
Published: January 2017

Abstract
In the frame structure of stacker cranes harmful mast vibrations may appear due to the inertial forces of acceleration or the braking movement phase. This effect may reduce the stability and positioning accuracy of these machines. Unfortunately, their dynamic properties also vary with the lifted load magnitude and position. The purpose of the paper is to present a controller design method which can handle the effect of a varying lifted load magnitude and position in a dynamic model and at the same time reveals good reference signal tracking and mast vibration reducing properties. A controller design case study is presented step by step from dynamic modeling through to the validation of the resulting controller. In the paper the dynamic modeling possibilities of single-mast stacker cranes are summarized. The handling of varying dynamical behavior is realized via the polytopic LPV modeling approach. Based on this modeling technique, a gain-scheduled controller design method is proposed, which is suitable for achieving the goals set. Finally, controller validation is presented by means of time domain simulations.
Comparison of Titanium Metal Matrix Composite Surface Layers Produced During Laser Gas Nitriding of Ti6Al4V Alloy by Different Types of Lasers
Authors: Lisiecki A. 
Published: January 2017

Abstract
The article presents the results of a comparative study of the nitriding process of titanium alloy substrate using two lasers with different characteristics of laser beams. One of the applied lasers was a high power diode laser emitting at a dominant wavelength of 808 nm, with a rectangular laser beam spot, and multimode energy distribution across the spot. The second laser was a solid state Yb:YAG disk laser emitting at a wavelength of 1.03 μm, with a circular beam spot, characterized by near Gaussian energy distribution across the spot. In a case of both lasers single stringer beads with a similar width and at similar energy input were produced. As a result of melting of the substrate with a laser beam in a pure gaseous nitrogen atmosphere composite surface layers with in situ precipitated titanium nitrides embedded in the metallic matrix of titanium alloy were produced, in both cases. However, the surface topography and structure is different for the surface layers produce by different lasers at the same processing parameters and width of laser beams.
Sliding Wear Behaviour and Corosion Resistance to Ringer’s Solution of Uncoated and DLC Coated X46Cr13 Steel
Authors: Scendo M. , Radek N. , Konstanty J. , Staszewska K. 
Published: January 2017

AbstractSliding wear properties and corrosion resistance in Ringer’s solution of uncoated and diamond-like carbon (DLC) coated X46Cr13 steel was tested. The Raman spectra showed that the DLC film was successfully coated by plasma assisted CVD method onto the steel surface. The wear test, carried out using a ball-on disk tribometer, revealed that the DLC coating show better resistance to sliding wear and lower friction coefficient against a 100Cr6 steel ball than five times softer X46Cr13 steel. The oxidation kinetic parameters were determined by means of both the gravimetric and electrochemical method. It was found that the DLC coating markedly decreased the rate of corrosion of the X46Cr13 steel, irrespective of the corrosion mechanism involved.
The Influence of the Model Selected Parameter Measurement Error on the Accuracy of Heat Transfer Coefficient Determination Method for Contact between Rolls and the Cast Strand
Authors: Rywotycki M. 
Published: January 2017

AbstractThe paper presents a heat transfer model between two surfaces which are in contact under an external force. The developed heat transfer boundary condition model has been obtained using a new methodology for determining heat flux transferred between two solid surfaces. The methodology consists of two parts: experimental and numerical one. The experimental part involves measurements of temperature at specific points in two samples brought into contact. The numerical part uses an inverse method and the finite element method to calculate the heat flux at the interface.The effect of uncertainty of input parameters for the calculation of heat transfer coefficient has been analysed. These have included: thermal conductivity, specific heat and location of thermocouples. Verification calculation with new value of input parameters for their impact on the accuracy of the solution has been done.The calculations have been performed using original software which uses the inverse method and FEM.
Assessment of the Harmfulness of Moulding Sands with Alkyd Resin Subjected to the High Temperature Influence
Authors: Holtzer M. , Dańko R. , Żymankowska-Kumon S. , Kubecki M. , Bobrowski A. 
Published: January 2017

Abstract
Out of moulding sands used in the foundry industry, sands with organic binders deserve a special attention. These binders are based on synthetic resins, which ensure obtaining the proper technological properties and sound castings, however, they negatively influence the environment. These resins in their initial state these resins are not very dangerous for people and for the environment, thus under an influence of high temperatures they generate very harmful products, being the result of their thermal decomposition. Depending on the kind of the applied resin, under an influence of a temperature such compounds as: furfuryl alcohol, formaldehyde, phenol, BTEX group (benzene, toluene, ethylbenzene, xylene), and also polycyclic aromatic hydrocarbons (PAHs) can be formed and released.
The aim of the study was the development of the method, selection of analytical methods and the determination of optimal conditions of formation compounds from the BTEX and PAHs group. Investigations were carried out in the specially designed set up for the thermal decomposition of organic substances in a temperature range: 500 – 1 300°C at the laboratory scale. The object for testing was alkyd resin applied as a binding material for moulding sands. The qualitative and quantitative analyses of compounds were performed by means of the gas chromatography coupled with the mass spectrometry (GC/MS).
Comparative dimensional study between panoramic X-ray (OPG) and cone beam CT (CBCT)
Authors: Tonea Marinela , Ivanciu Crina , Trascu C. , Dogioiu F.C. , Damian I. , Cosconel Cristiana , Epistatu D. 
Published: January 2017

Abstract
During daily practice, we find various situations in which the 1/1 correspondence between panoramic x-ray (OPG) and reality seems not to be respected. In the studied literature, there are articles on this subject, but our study was made based on cases in a highly frequented dental imaging clinic in Bucharest. The study was carried out on a number of 24 patients selected from the radiology department. Using Romexis Viewer software, with soft’s specific feature, measurements have been made (in approximately horizontal and approximately vertical axis) in three different areas: anterior, bicuspid and molar. Various results have been obtained, depending on the studied area. CBCT measured length of anterior teeth was higher than that measured on OPG, in the majority of cases. Molar width (mesio-distal distance) parameter variation was very small between OPG and CBCT.