bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissecting persistent instability of web service: A joint perspective of server schedule dynamics and path latency
Authors: Xue Jing'an , Wang Jilong , Liu Shengchao , Ma Xiulin , Wang Haibo 
Published: October 2017

SummaryWeb service has become very popular because of its portal role like searching and video streaming, as well as its convenience of building. Complex communication and computation infrastructures behind modern web service are brought forward to satisfy diverse requirements, such as content delivery networks and clouds. However, no longitudinal studies about web serving pattern dynamics have been performed.To investigate the joint communication and computation patterns, we conducted a 1‐year fine‐grained measurement on world and China top 500 websites. Specifically, we examined path latency (perspective of communication) combined with hosting server dynamics (perspective of computation) from a longitudinal view of end user. Our result shows that persistent latency instability could exist with 2 contributors. One is persistent diurnal pattern, which exhibits significant daily latency discrepancy from 60 to 360 ms and can exist up to nearly 120 days out of 1 year. Another factor is dynamic server schedule. We design metrics and estimate to what extent server dynamics takes on over a long‐term period and how it correlates with end‐to‐end latency. Further, we take a look at topological and geographical factors of server changes that affect path latency instability. The result shows that world and China top sites have different spatial dominators in terms of server change–related latency instability.
A survey of overlay and underlay paradigms in cognitive radio networks
Authors: Kumar Bhoopendra , Kumar Dhurandher Sanjay , Woungang Isaac 
Published: October 2017

SummaryIn the recent years, wireless applications and services have grown tremendously, resulting to a shortage of radio spectrum. On one hand, most of the available radio spectrum has already been allocated to different users and service providers. On another hand, research and statistics have revealed that the spectrum utilization usability is very limited. To address this dilemma, the concept of cognitive radio has emerged, which promotes the use of overlay and underlay transmission techniques to boost the utilization of radio spectrum resources. This paper provides a comprehensive survey of these 2 techniques and compares them qualitatively based on several network parameters. Next, this paper simulates overlay and underlay transmission techniques in OMNeT++ simulator on different network parameters, namely, Primary user arrival rate, throughput, sensing duration, and energy consumption. Our findings reveal that neither the overlay nor the underlay technique is sufficient itself to fulfill the demands for future wireless systems, and adopting a hybrid access technique consisting of a joint utilization of overlay and underlay approaches is desirable. Furthermore, the key challenges and open research issues in radio spectrum resources utilization are discussed.
Cytology and high risk HPV testing in cervical cancer screening program: Outcome of 3‐year follow‐up in an academic institute
Authors: Yang Jack , Nolte Fredrick S. , Chajewski Olga S. , Lindsey Kathryn G. , Houser Patricia M. , Pellicier Jalidsa , Wang Qun , Ehsani Laleh 
Published: October 2017

BackgroundCombination of cervical cytology and high‐risk human papillomavirus (HR‐HPV) testing, co‐testing, has been increasingly used in screening cervical cancers. The present study summarized the outcome of co‐testing by reviewing 3‐year clinical and pathological follow‐up information.MethodsPatients were retrospectively identified via computerized search and were grouped based on the cytologic diagnosis and HR‐HPV status as negative for intraepithelial lesion or malignancy (NILM)/HPV–, NILM/HPV+, atypical squamous cells of undetermined significance (ASC‐US)/HPV–, ASC‐US/HPV+, low grade squamous intraepithelial lesion (LSIL)/HPV–, LSIL/HPV+, atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (ASC‐H)/HPV–, ASC‐H/HPV+, high grade squamous intraepithelial lesion (HSIL)/HPV–, and HSIL/HPV+. The patients' pertinent past medical history and follow‐up information were analyzed.ResultsDuring 3‐year follow‐up period, histologically proven HSIL was found in 5 of 1565 (0.3%) patients with NILM/HPV–, 7 of 141 (5.0%) with NILM/HPV+, 2 of 502 (0.4%) with ASC‐US/HPV–, 30 of 274 (10.9%) with ASC‐US/HPV+, 1 of 81 (1.2%) with LSIL/HPV–, 28 of 159 (17.6%) with LSIL/HPV+, 3 of 18 (16.7%) with ASC‐H/HPV–, 34 of 69 (49.3%) with ASC‐H/HPV+, 7 of 7 (100%) with HSIL/HPV–, and 35 of 56 (62.5%) HSIL/HPV+. In reviewing 12 HSIL cases that were originally diagnosed as NILM, 7 remained as NILM, and the other 5 were reclassified as 1 HSIL, 1 ASC‐H, and 3 ASC‐US, respectively. In 18 HSIL cases with negative HR‐HPV, 12 patients had a prior history of positive HR‐HPV testing and/or positive p16 IHC stain in the follow‐up cervical biopsy.ConclusionHR‐HPV testing plays an important role in cervical cancer screening by identifying HSIL in patients with ASC‐US, LSIL, and NILM. Co‐testing is an optimal method to identifying the patients with higher risk for developing cervical abnormalities.
Roads to ruin: conservation threats to a sentinel species across an urban gradient
Authors: Feist Blake E. , Buhle Eric R. , Baldwin David H. , Spromberg Julann A. , Damm Steven E. , Davis Jay W. , Scholz Nathaniel L. 
Published: October 2017

AbstractUrbanization poses a global challenge to species conservation. This is primarily understood in terms of physical habitat loss, as agricultural and forested lands are replaced with urban infrastructure. However, aquatic habitats are also chemically degraded by urban development, often in the form of toxic stormwater runoff. Here we assess threats of urbanization to coho salmon throughout developed areas of the Puget Sound Basin in Washington, USA. Puget Sound coho are a sentinel species for freshwater communities and also a species of concern under the U.S. Endangered Species Act. Previous studies have demonstrated that stormwater runoff is unusually lethal to adult coho that return to spawn each year in urban watersheds. To further explore the relationship between land use and recurrent coho die‐offs, we measured mortality rates in field surveys of 51 spawning sites across an urban gradient. We then used spatial analyses to measure landscape attributes (land use and land cover, human population density, roadways, traffic intensity, etc.) and climatic variables (annual summer and fall precipitation) associated with each site. Structural equation modeling revealed a latent urbanization gradient that was associated with road density and traffic intensity, among other variables, and positively related to coho mortality. Across years within sites, mortality increased with summer and fall precipitation, but the effect of rainfall was strongest in the least developed areas and was essentially neutral in the most urbanized streams. We used the best‐supported structural equation model to generate a predictive mortality risk map for the entire Puget Sound Basin. This map indicates an ongoing and widespread loss of spawners across much of the Puget Sound population segment, particularly within the major regional north‐south corridor for transportation and development. Our findings identify current and future urbanization‐related threats to wild coho, and show where green infrastructure and similar clean water strategies could prove most useful for promoting species conservation and recovery.
Integrating Ecological Indicators into Federal‐State Fiscal Relations: A policy design study for Germany
Authors: Droste Nils , Ring Irene , Schröter‐Schlaack Christoph , Lenk Thomas 
Published: October 2017

AbstractProtected areas (PA) provide conservation benefits and ecosystem services that spill over the boundaries of jurisdictions to other regions. In this paper we analyse the foundations of and design options for ecological fiscal transfers (EFT) that may internalize such positive external effects. We propose a model for integrating ecological indicators into the intergovernmental fiscal transfer system between federal and state‐level governments in Germany. Our approach is performance oriented and would thus compensate those states that designate an above‐average share of their area for nature conservation purposes. The suggested EFT design builds upon the existing fiscal equalization system and complies with the legal requirements for indicators determining fiscal needs. We employ an econometric analysis to demonstrate that, on average, sparsely populated states in Germany provide more PA per capita and would thus be eligible for increased fiscal transfers. A quantitative model of the fiscal transfer scheme is then used to estimate the marginal financial effects of integrating ecological indicators into federal–state fiscal relations in Germany. Moving beyond the specific case presented, we discuss the implications in terms of the specific role of EFT as a policy instrument within the broader conservation policy mix. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Using copulas to estimate the coefficient of a binary endogenous regressor in a Poisson regression: Application to the effect of insurance on doctor visits
Authors: Zimmer David 
Published: October 2017

SummaryThis paper presents a copula‐based method for identifying and estimating the coefficient of a binary endogenous regressor in a Poisson regression. The method offers advantages over existing approaches. Most importantly, it relies upon standard maximum likelihood approaches, and it does not require numerical integration. Further, as part of its implementation, the method provides a convenient test for the presence of endogeneity. The empirical application investigates the effect of insurance status (a binary measure) on doctor visits (a count measure).
RETRACTED: Randomized controlled trial of the effect of endometrial injury on implantation and clinical pregnancy rates during the first ICSI cycle
Authors: Maged Ahmed M. , Rashwan Hamsa , AbdelAziz Suzy , Ramadan Wafaa , Mostafa Walaa A.I. , Metwally Ahmed A. , Katta Maha 
Published: October 2017

AbstractObjectiveTo assess whether endometrial injury in the cycle preceding controlled ovarian hyperstimulation during intracytoplasmic sperm injection (ICSI) improves the implantation and pregnancy rates.MethodsBetween January 1, 2016, and March 31, 2017, a randomized controlled trial was conducted at a center in Egypt among 300 women who met inclusion criteria (first ICSI cycle, aged <40 years, day‐3 follicle‐stimulating hormone <10 IU/L, normal serum prolactin, no uterine cavity abnormality). The women were randomly allocated using a web‐based system to undergo endometrial scratch in the cycle preceding controlled ovarian hyperstimulation (n=150) or to a control group (n=150). Only data analysts were masked to group assignment. The primary outcomes were the implantation and clinical pregnancy rates at 14 days and 4 weeks after embryo transfer, respectively. Analyses were by intention to treat.ResultsThe implantation rate was significantly higher in the endometrial scratch group (41.3% [90/218]) than in the control group (30.0% [63/210]; P<0.001). The clinical pregnancy rate was also significantly higher in the endometrial scratch group (44.2% [61/138]) than in the control group (30.4% [41/135]; P<0.001).ConclusionEndometrial injury in the cycle preceding the stimulation cycle improved implantation and pregnancy rates during ICSI.ClinicalTrials.govNCT02660125
Determining the cross‐talk between smooth muscle cells and macrophages on a cobalt‐chromium stent material surface using an in vitro postimplantation coculture model
Authors: Anderson Jordan A. , Lamichhane Sujan , Vierhout Thomas , Engebretson Daniel 
Published: October 2017

AbstractSmooth muscle cells (SMCs) and macrophages are important cellular components involved in the development of complications following the implantation of cardiovascular devices. This leads to various disorders such as restenosis, chronic inflammation, and may ultimately result in device failure. In this study, we developed a postimplant stent coculture model using different ratios of SMCs and macrophages seeded on to cobalt‐chromium alloy. The macrophages had an increased affinity to the coculture surfaces, which resulted in decreased SMC attachment to the alloy surfaces at the initial time point. Once adhered, the macrophages spread freely and displayed advanced stages of inflammation at 48 h when cocultured with SMCs. This resulted in an increased secretion of proinflammatory cytokines (tumor necrosis factor alpha, monocyte chemotactic protein 1, interleukin [IL]‐6, and IL‐8) by 48 h in the coculture samples with the greatest increase observed with the high number of macrophages. Therefore, the increased levels of proinflammatory cytokines promoted the growth of SMCs in coculture to a greater extent than when the SMCs were culture alone. Thus, this study demonstrated the constant cross‐talk between SMCs and macrophages occurring on the postimplant stent surface. Similar coculture models can be used to test the biocompatibility of drugs and biomaterials at possible postimplantation scenarios. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 673–685, 2018.
Poly(ionic liquids)‐coated stainless‐steel wires packed into a polyether ether ketone tube for in‐tube solid‐phase microextraction
Authors: Feng Juanjuan , Wang Xiuqin , Tian Yu , Luo Chuannan , Sun Min 
Published: October 2017

AbstractAn in‐tube solid‐phase microextraction device was developed by packing poly(ionic liquids)‐coated stainless‐steel wires into a polyether ether ketone tube. An anion‐exchange process was performed to enhance the extraction performance. Surface properties of poly(ionic liquids)‐coated stainless‐steel wires were characterized by scanning electron microscopy and energy dispersive X‐ray spectrometry. The extraction device was connected to high‐performance liquid chromatography equipment to build an online enrichment and analysis system. Ten polycyclic aromatic hydrocarbons were used as model analytes, and important conditions including extraction time and desorption time were optimized. The enrichment factors from 268 to 2497, linear range of 0.03–20 μg/L, detection limits of 0.010–0.020 μg/L, extraction and preparation repeatability with relative standard deviation less than 1.8 and 19%, respectively were given by the established online analysis method. It has been used to detect polycyclic aromatic hydrocarbons in environmental samples, with the relative recovery (5, 10 μg/L) in the range of 85.1–118.9%.
A two‐phase SPH model for debris flow propagation
Authors: Pastor M. , Yague A. , Stickle M.M. , Manzanal D. , Mira P. 
Published: October 2017

SummaryThis paper presents a model which can be used for fast landslides where coupling between solid and pore fluid plays a fundamental role. The proposed model is able to describe debris flows where the difference of velocities between solid grains and fluid is important. The approach is based on the mathematical model proposed by Zienkiewicz and Shiomi, which is similar to those of Pitman and Le and Pudasaini. The novelty of the present work is the numerical technique used, the smoothed particle hydrodynamics (SPH). We propose to use a double set of nodes for soil and water phases, the interaction between them being described by a suitable drag law. The paper presents both mathematical and numerical models, describing the main assumptions and their limitations. Then, the model is applied to (1) a simple case where shocks and expansion waves appear, (2) a dam break problem on a horizontal plane with a frictional soil phase, and (3) a debris flow which happened in Hong Kong. The main conclusions that can be drawn from the applications are:

Debris flows having 2 phases with important relative mobility present a rich structure of shocks and rarefaction waves, which has to be properly modeled. Otherwise, the model will have numerical damping or dispersion.
Dambreak exercises provide interesting information in simple and controlled situations. We can see how both phases move relative to each other.
Real debris flows can be simulated with the proposed model, obtaining reasonable results.
Alleviating time inconsistent behaviors via a competition scheme
Authors: Cui Xiangyu , Shi Yun , Xu Lu 
Published: October 2017

AbstractUnder quasi‐hyperbolic discounting, the valuation of a payoff falls relatively rapidly for earlier delay periods, but then falls more slowly for longer delay periods. When the salespersons with quasi‐hyperbolic discounting consider the product sale problem, they would exert less effort than their early plan, thus resulting in losses of future profit. We propose a winner‐takes‐all competition to alleviate the above time inconsistent behaviors of the salespersons, and allow the company to maximize its revenue by choosing an optimal bonus. To evaluate the effects of the competition scheme, we define the group time inconsistency degree of the salespersons, which measures the consequence of time inconsistent behaviors, and two welfare measures, the group welfare of the salespersons and the company revenue. We show that the competition always improves the group welfare and the company revenue as long as the company chooses to run the competition in the first place. However, the effect on group time inconsistency degree is mixed. When the optimal bonus is moderate (extreme high), the competition motivates (over‐motivates) the salesperson to work hard, thus alleviates (worsens) the time inconsistent behaviors. © 2017 Wiley Periodicals, Inc. Naval Research Logistics 64: 357–372, 2017
Three dimensional hybrid‐Trefftz stress finite elements for plates and shells
Authors: Martins P. H. C. , Bussamra F. L. S. , Lucena Neto E. 
Published: October 2017

SummaryThree‐dimensional hybrid‐Trefftz stress finite elements for plates and shells are proposed. Two independent fields are approximated: stresses within the element and displacement on their boundary. The required stress field derived from the Papkovitch‐Neuber solution of the Navier equation, which a priori satisfies the Trefftz constraint, is generated using homogeneous harmonic polynomials. Restriction on the polynomial degree in the coordinate measured along the thickness direction is imposed to reduce the number of independent terms. Explicit expressions of the corresponding independent polynomials are listed up to the fifth order. Illustrative applications to evaluate displacements and stresses are conducted by hexahedral hybrid‐Trefftz stress element models. The hierarchical p‐ and h‐refinement strategy are exploited in the numerical tests.
Successful management of transfusion‐dependent congenital dyserythropoietic anemia type 1b with interferon alfa‐2a
Authors: Rathe Mathias , Møller Michael Boe , Greisen Pernille Wied , Fisker Niels 
Published: October 2017

AbstractThe congenital dyserythropoietic anemias (CDAs) are a group of rare inherited blood disorders characterized by ineffective erythropoiesis as the principal cause of anemia. We present a child with CDA 1b—the rarest and least well‐described type—due to a mutation in the C15orf41 gene. The patient presented with severe in utero and neonatal manifestations, typical peripheral limb anomalies as well as rarely reported cardiac manifestations, visual impairment, short stature, and hip dysplasia. Anemia was complicated by iron overload and pronounced extra medullary erythropoiesis leading to skull deformities. The patient responded to treatment with pegylated interferon alfa‐2a.
To what extent do data from pharmaceutical claims under‐estimate opioid analgesic utilisation in Australia?
Authors: Gisev Natasa , Pearson Sallie‐Anne , Karanges Emily A. , Larance Briony , Buckley Nicholas A. , Larney Sarah , Dobbins Timothy , Blanch Bianca , Degenhardt Louisa 
Published: October 2017

AbstractPurposeAlthough pharmaceutical claims are an essential data source for pharmacoepidemiological studies, these data potentially under‐estimate opioid utilisation. Therefore, this study aimed to quantify the extent to which pharmaceutical claims from Australia's national medicines subsidy programs (Pharmaceutical Benefits Scheme [PBS] and Repatriation Schedule of Pharmaceutical Benefits [RPBS]) under‐estimate prescription‐only and total national opioid utilisation across time and for different opioids. A secondary aim was to examine the impact of the 2012 policy change to record all PBS/RPBS dispensed medicines, irrespective of government subsidy, on the degree of under‐estimation.MethodsAggregated data on Australian opioid utilisation were obtained for the 2010 to 2014 calendar years, including all single ingredient and combination opioid analgesic preparations available on prescription or over‐the‐counter (OTC). Total opioid utilisation (oral morphine equivalent kilogrammes) was quantified using sales data from IMS Health and compared with pharmaceutical claims data from the PBS/RPBS.ResultsPBS/RPBS claims data did not account for 12.4% of prescription‐only opioid utilisation in 2014 and 19.1% in 2010, and 18.4% to 25.4% of total opioid use when accounting for OTC preparations. Between 2010 and 2014, 5.6% to 5.3% of buprenorphine, 8.1% to 6.3% fentanyl, 17.7% to 10.7% oxycodone, 18.4% to 11.0% tramadol, 38.4% to 21.0% hydromorphone, and 28.6% to 21.0% of prescription‐only codeine utilisation were not accounted for in PBS/RPBS claims.ConclusionsDespite increased capture of less expensive (under co‐payment) opioid items since 2012, PBS/RPBS claims still under‐estimate opioid use in Australia, with varying degrees across opioids. The estimates generated in this study allow us to better understand the degree of under‐estimation and account for these in research using Australia's national pharmaceutical claims data.
Acute cardiovascular effects of bitter orange extract (p‐synephrine) consumed alone and in combination with caffeine in human subjects: A placebo‐controlled, double‐blind study
Authors: Ratamess Nicholas A. , Bush Jill A. , Stohs Sidney J. , Ellis Nicole L. , Vought Ira T. , O'Grady Elizabeth A. , Kuper Jeremy D. , Hasan Saif B. , Kang Jie , Faigenbaum Avery D. 
Published: October 2017

The purpose was to examine cardiovascular responses to supplementation with p‐synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects were given (in double‐blind manner) either 103 mg of p‐synephrine (S), 233 mg of caffeine +104 mg of p‐synephrine (LC + S), 240 mg of caffeine (LC), 337 mg of caffeine +46 mg of p‐synephrine (HC + S), 325 mg of caffeine (HC), or a placebo. The subjects sat quietly for 3 hr while heart rate (HR) and blood pressure were measured. Only HC + S and HC significantly increased mean systolic blood pressure (SBP) during the second hour and tended to increase mean SBP during the third hour. Mean diastolic blood pressure in S was significantly lower than the other trials during the first and second hours, and mean arterial pressure was significantly lower in S compared to the LC, LC + S, HC, and HC + S trials. No differences were observed in HR. Consumption of p‐synephrine may acutely reduce diastolic blood pressure and mean arterial pressure and not affect SBP or HR during quiet sitting. The addition of p‐synephrine to caffeine did not augment SBP or HR indicating that consumption of up to 104 mg of p‐synephrine does not induce cardiovascular stress during quiet sitting.