bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Development of Band Keratopathy of Corneal Graft Associated with Treatment with Intracameral Recombinant Tissue Plasminogen Activator for Postoperative Fibrin Reaction
Authors: Spitzer M.S. , Szurman P. , Aisenbrey S. , Rohrbach J.M. 
Published: January 2018

Purpose. To report a corneal transplant complication associated with intracameral recombinant tissue plasminogen activator (rTPA) treatment of postoperative fibrin reaction. Methods. In a 71-year-old patient, a triple procedure was performed for perforated rheumatic ulcer and secondary cataract. Results. A dense band keratopathy developed rapidly within 36 hours after the use of intracameral injection of rTPA for the treatment of a dense fibrin clot. Conclusions. This is the first report of rapid development of massive band keratopathy in a corneal graft after triple procedure and treatment with intracameral rTPA. Intracameral rTPA should be used with caution in patients with attenuated endothelium.
Ahmed Valve for Elevated Intraocular Pressure Associated with Black Diaphragm Lenses for Aniridia
Authors: Lanzagorta-Aresti A. , Menezo-Rozalen J.L. , Martínez-Costa R. , Cisneros-Lanuza á. 
Published: January 2018

Purpose. To evaluate the Ahmed valve for decrease elevated pressure associated with black diaphragm lenses for aniridia. Methods. Drainage devices are useful to obtain good control of intraocular pressure in patients with aniridia and the authors often use them because of the poor results of medical therapy or filtering surgery. However, when the elevated intraocular pressure is associated with black diaphragm lenses for aniridia, most authors decide to carry out a filtering technique. The current authors opted for the implantation of an Ahmed valve in three patients, two with traumatic aniridia and the other with a congenital case. Every patient had a different kind of black diaphragm lens for aniridia. Results. The Ahmed valve controlled the intraocular pressure in levels below 20 mmHg for a follow-up year with no complications derived from its application. Conclusions. Ahmed valve implantation was the best technique to decrease intraocular pressure in patients with aniridia. The authors have used it successfully for cases with elevated pressure associated with black diaphragm lenses for aniridia.
Actinomyces Neuii Subspecies Anitratus Chronic Endophthalmitis after Cataract Surgery
Authors: Pérez-Santonja J.J. , Campos-Mollo E. , Fuentes-Campos E. , Samper-Giménez J. , Alió J.L. 
Published: January 2018

Purpose. To report a case of unusual chronic endophthalmitis by Actinomyces neuii subspecies anitratus. Methods. A 75-year-old man underwent uneventful phacoemulsification with implantation of a foldable posterior chamber intraocular lens in his right eye. Four weeks after surgery, a chronic postoperative endophthalmitis characterized by anterior chamber and vitreous cellular debris developed in this eye. Cultures were positive, and A neuii subspecies anitratus was identified by polymerase chain reaction and subsequent rRNA sequence analysis. Immediate treatment included intravitreal and intensive topical antibiotics along with oral ciprofloxacin. Results. The condition improved rapidly, and 6 months after surgery the patient was asymptomatic, the best spectacle-corrected visual acuity was 20/22, and the anterior chamber was quiet. Conclusions. A neuii subspecies anitratus should be considered in the differential diagnosis of chronic endophthalmitis after cataract surgery. Polymerase chain reaction and subsequent RNA typing were useful in detecting the causative organism, and intravitreal antibiotics were successful.
Optic Nerve Compartment Syndrome in a Patient with Optic Nerve Sheath Meningioma
Authors: Jaggi G.P. , Mironov A. , Huber A.R. , Killer H.E. 
Published: January 2018

Purpose. To report a patient with optic nerve (ON) sheath meningioma, unilateral optic disc swelling, and inhomogeneous cerebrospinal fluid (CSF) composition between lumbar CSF and CSF from the subarachnoid space (SAS) of the affected ON. Methods. A 39-year-old woman presented with unilateral optic disc swelling and slight deterioration of visual function in the left eye. Extensive laboratory workup and magnetic resonance imaging (MRI) of the brain and orbits were performed. As radiotherapy was refused by the patient, ON sheath fenestration (ONSF) was offered and performed in order to stop deterioration. CSF from the SAS of the ON was sampled. Results. Laboratory workup was within normal limits. MRI of the left orbit demonstrated enhancement of the dura in the precanalicular portion of the ON and distension of the SAS, most prominent in the bulbar portion of the ON. On lumbar puncture the opening pressure measured 19 (cm H2O). Compared to the lumbar CSF the CSF of the affected ON SAS showed markedly elevated measurements for albumin, IgG, and beta-trace protein. Visual function remained stable over a follow-up time of 18 months. Conclusions. Composition of CSF is considered to be homogenous throughout all CSF spaces. In this patient the authors found a marked concentration-gradient of albumin, IgG, and beta-trace protein between the CSF in the spinal canal and the CSF in the SAS of the affected ON. Based on the radiologic features of the left ON and the dissociated beta-trace protein concentrations in the CSF of the SAS of the ON and the lumbar CSF, the diagnosis of an ON sheath compartment syndrome due to an ON sheath meningioma was made.
Adjunctive Use of Tafluprost with Timolol Provides Additive Effects for Reduction of Intraocular Pressure in Patients with Glaucoma
Authors: Egorov Evgeny , Ropo Auli ,   Tafluprost adjunctive therapy Study Group, Egorov Evgeny , Erichev Valery , Astakhov Yury , Alekseev Vladimir , Takhchidi Khristo , Zhaboedov Gennadiy , Pasechnikova Natalija , Kaljurand Kuldar , Palumaa Kadi , Laganovska Guna , Eugeny Russia–Egorov , Eugeny Alexeevich , Staritskaya Tatianavasi Lierna , Evgen'evna Egorova Tatyana , Borisovna Romanova Tatyana , Sheremetyeva Svetlana Sergeevna , Oganezova Janna Grigorievna , Petrovich Erichev Valeriy , Vagizona Yakoubova Liya , Sergueevich Astakhov Yuri , Alekseevna Dal Galina , Borisovna Lisochkina Alla , Kasimovna Atlasov Aliya , Victorovich Pani Nandrey , Alexeev Vladimir , Levko Michael , Martynova Elena , Kolotov Alexander , Takhchidi Khristoperi Klovich , Mironova Emilia Mikhailovna , Proshina Olga I. , Kozlova Elena E. , Sochinskaya Valentina K. , Grishina Tamara S. , Zhaboedov Gennadiy D. , Zhaboedov Ukraine–Gennadiy D. , Petrenko Oksana V. , Tymoshenkova Oksana Vladymyrivna , Vitovska Oksana P. , Kurilina Olena I. , Parkhomenko Oleg G. , Pasechnokova Natalija V. , Korol Andriy Rostislavovich , Klyuev Georgiy O. , Romodanova Kateryna Sergeevna , Nevska Alla , Padanevych Emiliya , Kaljurand Estonia–Kuldar , Pastak Marko , Seljagina Natalia , Palumaa Kadi , Somma Kaire , Laganovska Latvia–Guna , Baumane Kristine 
Published: January 2018

Purpose This study investigated the efficacy and safety of tafluprost as an adjunctive therapy to timolol in patients with open-angle glaucoma or ocular hypertension, uncontrolled by timolol monotherapy. Methods This was a randomized, double-masked, parallel-group, multinational and multicenter 12-week phase III study. Tafluprost 0.0015% (once daily: 20:10) or vehicle were administered as adjunctive therapy to timolol 0.5% (twice daily: 08:00 and 20:00) for 6 weeks, after which all patients received tafluprost for 6 weeks. Intraocular pressure (IOP) measurements were conducted at 08:00, 10:00, and 16:00 at baseline, and weeks 2, 4, 6, and 12. Results A total of 185 patients were randomized to tafluprost (n = 96) or vehicle (n = 89). Reductions in IOP were seen in both groups, which were consistently more pronounced with tafluprost. At week 6, the change from baseline in diurnal IOP ranged from −5.49 to −5.82 mm Hg, and the overall treatment difference (tafluprost vehicle) was −1.49 mmHg (upper 95% confidence interval, −0.66; p<0.001, intention-to-treat population, repeated measurements of the analysis of covariance model). At week 12, the change from baseline ranged from −6.22 to −6.79 mmHg in the tafluprost group. Patients switched from vehicle to tafluprost achieved a similar decrease in IOP to those who received tafluprost throughout the study (group difference at 12 weeks, −0.09 mmHg, p=0.812). There were more ocular adverse events with tafluprost compared with vehicle (42% vs. 29%, respectively), but most were mild in severity. Conclusions As adjunctive therapy to timolol, tafluprost achieved a consistently greater reduction in IOP compared with vehicle, and was well tolerated.
Trabeculectomy and Phaco-Trabeculectomy with and without Peripheral Iridectomy
Authors: Kaplan-Messas Audrey , Cohen Yuval , Blumenthal Eytan Z. , Avni Isaac 
Published: January 2018

Purpose To compare the 1-year outcome of trabeculectomy and combined phaco-trabeculectomy that were performed with or without a peripheral iridectomy (PI). Methods In a large tertiary glaucoma clinic, with a single surgeon performing all surgeries, 47 patients scheduled to undergo either a primary trabeculectomy or phaco-trabeculectomy were prospectively randomized to surgery with or without peripheral iridectomy. Other than the inclusion (PI group) or omission (no PI group) of a PI, surgical technique and postoperative care were identical for the two groups. The two groups were compared for intraocular pressure (IOP), success rates, visual acuity (VA), and complication rates. Complete and qualified success rates were defined as IOP 18 mmHg or less with or without medications, respectively. Results The 1-year complete and qualified success rates were comparable for both groups. Complete success was observed in 70% of cases, and qualified success in more than 90%. One patient (4.3%) from the no-PI group developed an iris incarceration into the internal sclerectomy site on postoperative day 1, requiring surgical intervention. No other significant complications (blebitis, endophthalmitis, or choroidal hemorrhage) were encountered in any of the study patients. Conclusions This randomized prospective small scale study explored the possibility of sparing the need to perform a routine PI in trabeculectomy and phaco-trabeculectomy. These preliminary results suggest that the outcomes in the two groups are comparable, paving the way to a larger scale study evaluating the need for PI in modern trabeculectomy surgery.
Prognostic Factors that Determine Visual Outcome following Cataract Surgery Complicated by Vitreous Loss
Authors: Konstantopoulos Aristides , Yadegarfar Ghasem , Madhusudhana Khrishnapa , Canning Chris R. , Luff Andrew J. , Anderson David F. , Hossain Parwez N. 
Published: January 2018

Purpose To identify prognostic factors that determine visual outcome following phacoemulsification cataract surgery complicated by vitreous loss. Methods A retrospective cohort study. All cases of vitreous loss during phacoemulsification surgery at a university hospital, between June 2000 and December 2005, were identified from the hospital computer database. By reviewing the medical notes, preoperative, intraoperative, and postoperative data were collected. Outcome of interest was presence of poor visual outcome (best-corrected visual acuity [BCVA] <6/12). Chi-square and Mann-Whitney U tests were used to compare groups of poor and good visual outcome. Results A total of 230 consecutive cases (eyes) were identified; medical notes were available for 228. Mean patient age was 78.4 years (SD 11); median follow-up 13.4 weeks (range 1–203). In multivariable logistic regression analysis poor visual outcome was independently associated with poor preoperative vision (BCVA <6/12) (OR 3.78, 95% CI 1.76–8.11), age-related macular degeneration (OR 3.04, 95% CI 1.16–8.00), cystoid macular edema (OR 3.85, 95% CI 1.29–11.51), and secondary pars plana vitrectomy (PPV) for nuclear fragment loss (OR 4.42, 95% CI 1.03–19.02). Primary PPV for nuclear fragment loss, age >70, ocular comorbidity, axial length, vitreous loss during irrigation/aspiration, or lens implantation, anterior chamber lens, and secondary lens implantation were not significant associations (p≥ 0.05). In 33 (14.5%) eyes BCVA was reduced by at least one Snellen line compared to before surgery. Conclusions Poor visual outcome was associated with poor preoperative vision, age-related macular degeneration, cystoid macular edema, and secondary PPV following nuclear fragment loss. Primary PPV for nuclear fragment loss was not a significant association.
Bimanual Technique in Proliferative Diabetic Retinopathy Using an Optical Fiber-Free Intravitreal Surgery System: A Case Control Study
Authors: Shen Li-Jun , Wang Zhao-Yang , Qu Jia , Wang Qin-Mei 
Published: January 2018

Purpose To evaluate the results of bimanual membrane peeling technique with an optical fiber-free intravitreal surgery system (OFFISS) in eyes with fibrovascular proliferation due to diabetic retinopathy. Methods Fifteen eyes of 14 consecutive patients with severe fibrovascular proliferation due to diabetic retinopathy who underwent bimanual vitrectomy using the OFFISS and 15 eyes of 15 nonconsecutive patients with similar fundus condition who underwent vitrectomy using a conventional microscope system were compared in a retrospective, consecutive case-control series. Results Reattachment rates at 3 months following surgery for the cases and controls were 93% and 100%, respectively, and final reattachment rates for both were 100%. The best-corrected visual acuity improved by two lines or more in 100% of the cases as compared to 87% of the controls (p=0.48). The mean VA (logMAR) improved 1.08 in the cases and 0.93 in the controls at final examination (p=0.46). Surgical complications were rare in both groups (p>0.05). The mean duration of membrane peeling of the cases was significantly lower than the controls (p=0.01). Conclusions For complicated surgical manipulations such as membrane peeling in diabetic vitrectomy for severe fibrovascular proliferation, bimanual vitrectomy using the OFFISS is a more effective and safer alternative to the conventional vitrectomy method.
A Case of Subperiosteal Abscess of the Orbit with Central Retinal Artery Occlusion
Authors: Okamoto Yoshifumi , Hiraoka Takahiro , Okamoto Fumiki , Oshika Tetsuro 
Published: January 2018

Purpose To report a rare case of orbital subperiosteal abscess with central retinal artery occlusion that resulted in blindness. Methods A 60-year-old previously healthy woman was referred to the hospital with 4-day history of orbital cellulitis, progressive left eye pain, eyelid swelling, and 1-day history of visual impairment. The patient was diagnosed with subperiosteal abscess of the orbit on diagnostic imaging. Results An emergent surgical intervention was performed due to prominent visual impairment. One day after surgery, ophthalmoscopic examination revealed cherry-red spot of the left fundus and central retinal artery occlusion. The final vision of the left eye was no light perception. Conclusions Central retinal artery occlusion, which is a therapeutic emergency, can be associated with acute progression of space-occupying lesion in the orbit such as subperiosteal abscess.
Late Onset of Deep Corneal Vascularization: A Rare Complication of Intrastromal Corneal Ring Segments for Keratoconus
Authors: Cosar Cemile Banu , Sridhar M.S. , Sener Bozkurt 
Published: January 2018

Purpose To report deep corneal vascularization noted 3 years after intrastromal corneal ring segments (Intacs) implantation for the treatment of keratoconus. Methods A 33-year-old male keratoconus patient intolerant to rigid gas permeable contact lens in the right eye underwent Intacs implantation. At 2 years postoperatively, slit-lamp examination of the right eye revealed superficial corneal vascularization inferotemporally, extending 1.5 mm from the limbus. At 3 years postoperatively, the slit-lamp examination of the right eye revealed deep stromal vascularization extending to and arborizing along the temporal segment. Also, superficial vascularization was noted along the nasal segment inferiorly. The Intacs segments were then explanted. Results On post-explantation day 10, the deep vessels regressed to ghost vessels with topical corticosteroid therapy. Conclusions The authors present a rare case where deep corneal vascularization was noticed 3 years following Intacs implantation for keratoconus. All patients having superficial vascularization away from the incision site need to be followed for this rare complication.
Frosted Branch Angiitis with Undiagnosed Hodgkin Lymphoma
Authors: Hua Minh-Tri , Blaise Pierre , De Leval Laurence , Rakic Jean-Marie 
Published: January 2018

Purpose To report the case of a patient with bilateral frosted branch angiitis and undiagnosed Hodgkin lymphoma. Methods Review of clinical history, laboratory findings, histology of supraclavicular lymph node biopsy, and follow-up. Results A 22-year-old man presented with a sudden, bilateral visual loss. Fundus examination and fluorescein angiography disclosed a bilateral frosted branch angiitis that was dramatically responsive to systemic corticosteroid therapy. Laboratory tests were unremarkable but radiologic studies showed extensive mediastinal and supraclavicular lymphadenopathy. A supraclavicular lymph node biopsy led to the diagnosis of nodular sclerosis Hodgkin lymphoma. Conclusions The occurrence of frosted branch angiitis in combination with classical Hodgkin lymphoma, although possibly coincidental, raises the possibility of a paraneoplastic syndrome. Thus, we suggest that, for patients with frosted branch angiitis, Hodgkin lymphoma should be considered in the diagnostic workup.
Branch Retinal Vein Occlusion Followed by Central Retinal Artery Occlusion in Churg-Strauss Syndrome: Unusual Ocular Manifestations in Allergic Granulomatous Angiitis
Authors: De Salvo Gabriella , Calzi Concetta Li , Anastasi Mario , Lodato Gaetano 
Published: January 2018

Purpose To describe a rare branch retinal vein occlusion (BRVO) followed by central retinal artery occlusion (CRAO) in a patient with Churg-Strauss syndrome (CSS). Methods A 55-year-old man with a not yet diagnosed CSS developed a BRVO in the left eye and 1 year later a CRAO with painless and acute vision loss in the same eye. Medical history included bronchial asthma, history of allergy, eosinophilic pneumonia, bilateral pleuric and pericardial effusion, hypereosinophilia, and purpuric vasculitis. Results CRAO in the left eye was diagnosed by retinal whitening and a cherry red spot with coexisting old BRVO evidenced by previous laser photocoagulation. Corticosteroids and cyclophosphamide therapy improved his general condition but no visual recovery occurred. Conclusions BRVO and CRAO can occur in the same eye in CSS. In the presence of systemic signs or symptoms, it is important to rule out systemic vasculitis in order to start appropriate immune-modulatory treatment thereby avoiding unnecessary mortality.
Visual Disturbance as Initial Presentation of Hairy Cell Leukemia
Authors: Charalel Resmi A. , Jain Atul K. , Rachakonda Leelanand P. , Gaynon Michael W. 
Published: January 2018

Purpose Hairy cell leukemia (HCL) is a rare disorder that occasionally has visual symptoms after diagnosis. The authors present a case of HCL in which bilateral visual symptoms led to the initial diagnosis. Methods Observational case report. Results Bilateral decreased vision to 20/30 in the right eye and 20/40 in the left due to intraretinal and pre-retinal hemorrhages with no other systemic signs or symptoms prompted a hematologic evaluation in which HCL was found to be the causative disorder in a previously healthy 41-year-old man. Conclusions The authors present a rare case in which bilateral visual complaints led to the diagnosis of HCL. Thus, though uncommon, HCL should be considered in the differential diagnosis of otherwise unexplained retinal hemorrhages.
Optic Disc Pit Maculopathy Treated with Vitrectomy, Internal Limiting Membrane Peeling, and Gas Tamponade: A Report of Two Cases
Authors: Georgalas Ilias , Petrou Petros , Koutsandrea Chrysanthi , Papaconstadinou Dimitris , Ladas Ioannis , Gotzaridis Eustratios 
Published: January 2018

Purpose Two cases with optic disc pit associated maculopathy, treated with vitrectomy surgery, internal limiting membrane peeling (ILM) and gas tamponade, are presented. Methods Interventional case reports. Results Two patients with serous macular detachment associated with a congenital optic pit underwent vitrectomy surgery, induction of posterior vitreous detachment, peeling of the ILM, and gas tamponade. In both cases, complete resolution of intraretinal and subretinal fluid was observed within a few months after surgery. The retina remained attached during a follow-up of 12 months and the visual acuity of both patients improved. Conclusions Vitrectomy with ILM peeling and gas tamponade without any additional laser photocoagulation seems to be sufficient for the treatment of optic disc pit maculopathy. Further studies are required to evaluate the above findings, although the implementation of large-series studies remains a challenge due to the rarity of cases with optic disc maculopathy.
A New Stereotest for Strabismologists: The Covered two Pencil Test
Authors: Mojon Daniel S. 
Published: January 2018

Purpose The two pencil test (TPT) checks the ability to perform a simple visual-motor task. The test is only partially based on intact stereopsis, since monocular depth perception clues are involved. To overcome this shortcoming, a new test variant has been developed and tested. Methods By covering the tip of the examiner's rod, monocular cues should be drastically reduced. Twenty normal subjects performed the TPT and the covered two pencil test (CTPT) under monocular and binocular conditions. Each test condition was repeated 15 times. Four subjects were retested by three different examiners in order to determine the observer variation. Differences between the accuracy and observer variation of the two test variants under monocular and binocular condition were compared using the paired t test. Results The average difference between monocular and binocular accuracy was for the TPT 1.26 cm and for the CTPT 2.37 cm (p<0.0005). The average coefficients of variation of both test variants were similar, for the TPT 0.28 and for the CTPT 0.33 (p>0.1). Conclusions This study demonstrates that covering the tip of the examiner's rod approximately doubles the differences between monocular and binocular accuracy. Therefore, covering seems to reduce monocular cues and increase the stereoscopic value of the TPT.
The Efficacy of 5% Povidone-Iodine for 3 Minutes Prior to Cataract Surgery
Authors: Carrim Zia I. , Mackie Gordon , Gallacher Grace , Wykes William N. 
Published: January 2018

Purpose To evaluate the efficacy of 3 minutes of 5% povidone-iodine for skin and conjunctival antisepsis prior to cataract surgery as recommended by the European Society of Cataract and Refractive Surgeons. Methods A prospective controlled study of 54 patients undergoing unilateral cataract surgery by phacoemulsification was undertaken. The eye undergoing surgery was prepared with 5% povidone-iodine for 3 minutes. The other eye served as control. Swabs were taken from both eyes prior to application of 5% povidone-iodine and 3 minutes after. Proportion of culture-positive swabs, mean number of species, and growth of isolates on culture were compared at different times and between the two groups. Results Coagulase-negative Staphylococcus (CoNS) was the main species isolated from culture-positive swabs. Use of 5% povidone-iodine for 3 minutes resulted in a statistically significant reduction in proportion of culture-positive swabs (87% vs 30%, p<0.001), mean number of species (0.96±0.47 vs 0.30±0.46, p<0.001), and growth of CoNS (heavy: 30% vs 0%, moderate: 23% vs 6%, light: 47% vs 94%, p=0.004). No such changes were observed in the control group. Conclusions Use of 5% povidone-iodine for 3 minutes prior to cataract surgery achieves a significant reduction in organisms such as CoNS from lid and conjunctival flora.