bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risky consumption of alcohol and drugs among employees at ski resorts
Authors: Warne Maria , Sinadinovic Kristina , Berman Anne H , Källmén Håkan , Vinberg Stig 
Published: September 2017

Aim: To evaluate risky consumption of alcohol and drugs among Swedish men and women who are employed at ski resorts. Methods: A cross-sectional sample of 611 employees in 48 small and medium-sized enterprises responded to a questionnaire covering alcohol and drug use, social aspects around work and working conditions. Consumption of alcohol and drugs in the study sample was compared to population data. Data were analysed using Mann–Whitney U-tests and logistic regression analyses. Results: Compared to the general population, the study group of ski resort employees had higher scores on the Alcohol Use Disorders Identification Test (AUDIT) in all age groups except 35+ for men. Regarding the Drug Use Disorders Identification Test (DUDIT) scores, only men in the 18–24 age group had higher scores compared to the general population. The prevalence of risky alcohol and drug use was higher among seasonally employed individuals; 82.9%, compared to 58.0% among other employees for alcohol; 8.3% compared to 2.8% for drugs. The regression analysis indicated that social aspects such as living together with colleagues and having co-workers/friends who are frequently inebriated were the most significant explanatory variables for explaining risk consumption of alcohol ( OR 16.82 and OR 4.33). Risky use of drugs was associated with being younger ( OR 0.15) and male ( OR 0.86), as well as with having co-workers/friends who are frequently inebriated ( OR 4.25). Conclusions: The study showed a high prevalence of risky alcohol consumption among ski resort employees compared to the general population, with higher risky drug consumption found only among younger men. Social aspects such as living with colleagues and having co-workers or friends who are often inebriated, were identified as important explanatory factors. Preventive measures should be introduced, targeting norms and work culture surrounding alcohol and drug use among ski resort employees.
Self-reported health, use of alcohol and illicit drugs, and criminality among adults with foetal alcohol syndrome
Authors: Rangmar Jenny , Dahlgren Sandberg Annika , Aronson Marita , Fahlke Claudia 
Published: September 2017

Aims: To investigate self-reported physical and psychiatric problems, use of alcohol and illicit drugs, as well as conviction, and being a victim, of crime in adults with foetal alcohol syndrome (FAS). Methods: Interviews with 20 adults, aged 30±8 years with FAS diagnosis (65% female) and an age-and-gender-matched comparison group. Measures used were the Addiction Severity Index interview, the Beck Depression Inventory Scale and the Beck Anxiety Inventory Scale. Results and conclusions: Adults with FAS need healthcare for depression and suicidal ideation, which occurred commonly, but problems with use of alcohol and illicit drugs were not more common in the FAS group. Although self-reported physical health problems were not more common in the FAS group, their number of days with sickness leave indicated that they are often in too poor a physical condition to work. A majority of the FAS group had been victims of crime, which makes this an important topic for further research. The groups did not differ in crime conviction rates. Everyone in the study group had been diagnosed with FAS; a diagnosis may give access to social welfare interventions. More individuals within the FAS disorders spectrum need to be identified to be given access to efficient interventions.
Alcohol use among Norwegian students
Authors: Erevik Eilin K. , Pallesen Ståle , Vedaa Øystein , Andreassen Cecilie S. , Torsheim Torbjørn 
Published: September 2017

Aims: This study investigates demographic, personality, and psychological health correlates of different drinking patterns. Design: Students at the four largest institutions of higher education in Bergen municipality were invited via email to complete an internet-based questionnaire. The final sample size was 11,236 (39.4%), mean age 24.9 years ( SD = 6.5), and 63.3% were women. The survey included the Alcohol Use Disorder Identification Test (AUDIT) and questions about demographics, personality traits, and symptoms of depression and anxiety. Binary logistic regressions were used to identify correlates of different drinking patterns. Results: A total of 53.0% of the students had an AUDIT score of or above 8 (i.e., hazardous drinking). Being native Norwegian, male, single, without children, non-religious, extroverted, unconscientious, and less open to experience were associated with higher AUDIT scores, drinking frequently, and binge drinking. Having parents with high alcohol or drug use increased the odds of engaging in binge drinking, but this factor was not associated with frequent drinking. Students scoring higher on neuroticism and openness were less likely to report problematic alcohol usage. Conclusions: A majority of the students reported alcohol habits that are associated with harm if they persist. This emphasises the need to examine the long-term consequences of students’ alcohol use.
Hyperglycemic Episodes Are Associated With Postoperative Infections After Cardiac Surgery
Authors: Järvelä K. M. , Khan N. K. , Loisa E. L. , Sutinen J. A. , Laurikka J. O. , Khan J. A. 
Published: September 2017

Background and Aims: To describe the incidence of and risk factors for postoperative infections and the correlation between postoperative hyperglycemia despite tight blood glucose control with infectious and other complications after contemporary cardiac surgery. Material and Methods: The study comprised 1356 consecutive adult patients who underwent cardiac surgery between January 2013 and December 2014 and were followed up for 6 months. Patients surviving the first 2 days were included in the analysis. Preoperative demographic information, medical history, procedural details, and the postoperative course were recorded. The target range for blood glucose levels was 4–7 mmol/L and repeated arterial blood samples were obtained during the intensive care unit stay. The associations of blood glucose levels during the first postoperative day and the occurrence of postoperative infections and other significant complications were analyzed. Results: Of the study cohort, 9.8% developed infectious complications which were classified as major surgical site infections in 2.2%, minor surgical site infections in 1.1%, lung infections in 2.0%, unclear fever or bacteremia in 0.3%, cannula or catheter related in 2.6%, multiple in 1.5%, and other in 0.2%. The incidence of deep sternal wound infection was 2.0%. Repeated hyperglycemia occurred in 39.7% of patients and was associated with increased rates of postoperative infections, 12.1% versus 8.2%, p = 0.019; stroke, 4.9% versus 1.5%, p < 0.001; and mortality, 6.1% versus 2.1%, p < 0.001, when compared to patients with single or no hyperglycemia. Conclusion: Every 10th patient develops infectious complications after cardiac surgery. Repeated hyperglycemia is associated with increased rates of infectious complications, stroke, and mortality.
Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients
Authors: Dupont Laust , Eide Ivar Anders , Hartmann Anders , Christensen Jeppe Hagstrup , Åsberg Anders , Jenssen Trond , Krarup Henrik , Svensson My 
Published: September 2017

Background: Cardiovascular disease is the leading cause of death in renal transplant recipients. An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied. Methods: In this single-center retrospective cohort study of 1975 adult Norwegian transplant recipients, who underwent transplantation between 1999 and 2011, we estimated the risk of all-cause and cardiovascular mortality and overall and death-censored graft loss for patients with haptoglobin genotype 2-2 compared to genotype 2-1 or 1-1, after adjustment for confounders and competing risks. Results: We found no associations between haptoglobin genotype 2-2 and cardiovascular mortality (subdistributional hazard ratio 1.08, 95% confidence interval 0.78-1.49; P = .63). We also failed to detect any association between haptoglobin 2-2 genotype and all-cause mortality, overall graft loss, and death-censored graft loss. Similar results were found in the subpopulation of transplant recipients with diabetes. Conclusion: In this large cohort of kidney transplant recipients, we could not demonstrate any association between haptoglobin 2-2 genotype and patient or graft survival after renal transplantation.
Effectiveness of Anticipatory Guidance on the Knowledge and Attitude of Pregnant Women Attending Government Hospital, Thirumangalam, Madurai
Authors: Shanthini R. Priya , Garla Bharath Kumar , Karuppaiah R. Muthu , Taranath M. 
Published: September 2017

Aims and Objectives: Improving maternal knowledge plays a major role in developing good oral health habits and in preventing diseases like early childhood caries in their children. The present study is aimed to provide pregnant women with the anticipatory guidance and to evaluate its effect on promoting the knowledge and attitude of pregnant mothers regarding infant and toddler’s oral health care. Material and Method: In this interventional study, 600 pregnant women attending government hospital, Madurai, were divided into direct intervention, indirect intervention, and control groups. A self-reported questionnaire was completed before intervention. The anticipatory guidance was presented to the direct intervention group by PowerPoint and to the indirect group by pamphlets. Immediately after the intervention, the questionnaire was completed by intervention groups and two months later by all participants. Chi-square test was used for statistical analysis at a significance level of 0.05. Results: The change of scores in the knowledge and attitude of pregnant women had a significant difference in all the three groups. At the end of the study, a statistically significant difference ( p < 0.05) was noted in the knowledge between the intervention and the control groups. The change in the attitude was not statistically significant. Conclusion: Anticipatory guidance led to change in the score of knowledge about infant and toddler’s oral health in intervention groups compared to control group. The direct presentation had superiority over indirect presentation in increasing knowledge about their oral health care. Dentists should do their utmost to educate parents especially the pregnant mothers on children’s oral health in a culturally and linguistically appropriate manner, as oral health literacy is, ultimately, a pathway to health equity.
Multiligament Knee Injuries in Older Adolescents: A 2-Year Minimum Follow-up Study
Authors: Godin Jonathan A. , Cinque Mark E. , Pogorzelski Jonas , Moatshe Gilbert , Chahla Jorge , LaPrade Robert F. 
Published: September 2017

Background: Multiligament knee injuries cause significant functional impairment. Adults undergoing anatomic reconstruction of multiligament knee injuries have excellent outcomes postoperatively. However, less is known about the outcomes in adolescent patients following multiligament reconstruction. Purpose/Hypothesis: We aimed to assess patient outcomes and failure rates following unstaged multiligament reconstruction in an adolescent population at a minimum 2-year follow-up. We hypothesized that outcomes of multiligament reconstruction in these patients would be comparable to previously reported outcomes in the adult population. Study Design: Case series; Level of evidence, 4. Methods: The study included patients who had undergone multiligament knee reconstruction at 19 years of age or younger and had at least 2 years of follow-up. All procedures were performed by the same surgeon. Exclusion criteria included patient age 14 years or younger at the time of surgery, open physes, prior ipsilateral meniscal or knee ligament surgery, or a tibial plateau fracture at the time of injury. Multiligament reconstruction was defined as a reconstruction of at least 1 cruciate ligament and at least 1 component of the posterolateral corner or the medial knee. Patients were evaluated according to Lysholm score, Tegner score, Short Form–12 physical component summary (SF-12 PCS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and postoperative patient satisfaction. Results: Twenty patients (mean age, 17.7 years; mean follow-up, 37.1 months) were included in this study. No patient required additional ligament surgery after the index surgery because of graft failure. The median preoperative Lysholm score was 49.5 (range, 18-90), and the median postoperative Lysholm score was 86 (range, 44-100) ( P < .001). The median preoperative Tegner activity score was 2 (range, 0-9), and the median postoperative Tegner activity score was 6 (range, 2-10) ( P = .012). The median SF-12 PCS improved from 40.5 preoperatively to a median of 56.1 postoperatively ( P < .001). WOMAC total score improved from a median of 26.5 preoperatively to a median of 2 postoperatively ( P < .001). Median postoperative patient satisfaction was 10 (range, 5-10). Conclusion: Single-stage multiligament knee reconstruction is a reliable procedure that improves knee function at 2-year follow-up in adolescent patients. Patient satisfaction was excellent, but longer follow-up in a larger series of patients is required to determine the long-term benefits of multiligament reconstruction in this patient population.
Acute Versus Delayed Magnetic Resonance Imaging and Associated Abnormalities in Traumatic Anterior Shoulder Dislocations
Authors: Orvets Nathan D. , Parisien Robert L. , Curry Emily J. , Chung Justin S. , Eichinger Josef K. , Murakami Akira M. , Li Xinning 
Published: September 2017

Background: The delayed management of patients with shoulder instability may increase the prevalence and severity of concomitant intra-articular shoulder injuries resulting from persistent subluxations and dislocations. Hypothesis: Patients with a longer delay from the initial dislocation event to undergoing magnetic resonance imaging (MRI) or magnetic resonance arthrography will demonstrate more subluxations or dislocations and a greater amount of intra-articular shoulder damage. Study Design: Cohort study; Level of evidence, 3. Methods: We performed a retrospective review of 89 patients from a single institution with clinically and radiographically confirmed primary traumatic anterior shoulder dislocations. Patients were divided into 2 groups: those undergoing MRI less than 6 months (n = 44; LT6) or greater than 6 months (n = 45; GT6) from the initial dislocation event. The MRI assessment included evaluation of soft tissue injuries, including the labrum, capsule, rotator cuff, and cartilage damage severity along with bone loss. Results: The delayed MRI group (GT6) demonstrated a greater degree of intra-articular abnormalities compared to the early MRI group (LT6). A greater percentage of superior labral anterior-posterior (SLAP) tears (58% vs 34%, respectively) and cartilage damage (73% vs 27%, respectively) was present in the GT6 group compared to the LT6 group. Cartilage damage was 18% mild, 7% moderate, and 2% severe for the LT6 group as compared to 38% mild, 31% moderate, and 4% severe for the GT6 group. Additionally, more recurrent shoulder dislocations were seen in the GT6 group (n = 6) compared to the LT6 group (n = 2). In the LT6 group, there were more rotator cuff tears (50% vs 24%, respectively) and capsular tears (25% vs 9%, respectively) than the GT6 group. There was no difference in anterior glenoid bone loss, glenoid version, or humeral head subluxation between the 2 groups. Conclusion: Patients who undergo MRI greater than 6 months from the time of primary or initial shoulder dislocation had significantly more recurrent shoulder instability events and demonstrated a greater incidence and severity of intra-articular abnormalities, including SLAP tears, posterior labral tears, and anterior glenoid cartilage damage.
Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study
Authors: Bergsten Elisabet , Horne AnnaCarin , Aricó Maurizio , Astigarraga Itziar , Egeler R. Maarten , Filipovich Alexandra H. , Ishii Eiichi , Janka Gritta , Ladisch Stephan , Lehmberg Kai , McClain Kenneth L. , Minkov Milen , Montgomery Scott , Nanduri Vasanta , Rosso Diego , Henter Jan-Inge 
Published: September 2017

Key Points
Early introduction of cyclosporine did not improve HLH outcome in patients treated with the HLH-94 etoposide-dexamethasone backbone (P = .06). HLH-2004 may be improved by risk-group stratification, less therapy reduction weeks 7 to 8 for verified FHL patients, and earlier HSCT.
Gene editing rescue of a novel MPL mutant associated with congenital amegakaryocytic thrombocytopenia
Authors: Cleyrat Cédric , Girard Romain , Choi Eun H. , Jeziorski Éric , Lavabre-Bertrand Thierry , Hermouet Sylvie , Carillo Serge , Wilson Bridget S. 
Published: September 2017

Key Points
We report unique familial cases of CAMT presenting with a novel MPL W272R mutation in the background of the activating MPL K39N mutation. Function of mutant Mpl receptor can be rescued using 2 approaches: autophagic cell surface delivery and CRISPR-Cas9 gene editing.
Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy
Authors: Centeno Christopher , Markle Jason , Dodson Ehren , Stemper Ian , Williams Christopher J. , Hyzy Matthew , Ichim Thomas , Freeman Michael 
Published: September 2017

Abstract
Background
Degenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeutic options result in many turning to surgical alternatives for management, which vary in the rate of success and also carry an increased risk of morbidity and mortality associated with the procedures. Several animal based studies and a few human pilot studies have demonstrated safety and suggest efficacy in the treatment of DDD with mesenchymal stem cells (MSCs). The use of bone marrow-derived MSCs for the treatment of DDD is promising and in the present study we report on the safety and efficacy findings from a registry based proof of concept study using a percutaneous intradiscal injection of cultured MSCs for the management of DDD with associated radicular symptoms.

Methods
Thirty-three patients with lower back pain and disc degeneration with a posterior disc bulge diagnosed on magnetic resonance imaging (MRI) met the inclusion criteria and were treated with culture-expanded, autologous, bone marrow-derived MSCs. Prospective registry data was obtained at multiple time intervals up to 6 years post-treatment. Collected outcomes included numeric pain score (NPS), a modified single assessment numeric evaluation (SANE) rating, functional rating index (FRI), measurement of the intervertebral disc posterior dimension, and adverse events.

Results
Three patients reported pain related to procedure that resolved. There were no serious adverse events (i.e. death, infection, or tumor) associated with the procedure. NPS change scores relative to baseline were significant at 3, 36, 48, 60, and 72 months post-treatment. The average modified SANE ratings showed a mean improvement of 60% at 3 years post-treatment. FRI post-treatment change score averages exceeded the minimal clinically important difference at all time points except 12 months. Twenty of the patients treated underwent post-treatment MRI and 85% had a reduction in disc bulge size, with an average reduction size of 23% post-treatment.

Conclusions
Patients treated with autologous cultured MSCs for lower back pain with radicular symptoms in the setting of DDD reported minor adverse events and significant improvements in pain, function, and overall subjective improvement through 6 years of follow-up.
NCT03011398. A Clinical Registry of Orthobiologics Procedures. https://clinicaltrials.gov/ct2/show/NCT03011398?term=orthobiologics&rank=1
Effect of stage, comorbidities and treatment on survival among cancer patients with or without mental illness
Authors: Manderbacka Kristiina , Arffman Martti , Suvisaari Jaana , Ahlgren-Rimpiläinen Aulikki , Lumme Sonja , Keskimäki Ilmo , Pukkala Eero 
Published: September 2017

BackgroundEarlier research suggests poorer outcome of cancer care among people with severe mental illness (SMI).AimsTo assess the effect of stage at presentation, comorbidities and treatment on differences in survival among cancer patients with and without a history of SMI in Finland.MethodThe total population with a first cancer diagnosis in 1990–2013 was drawn from the Finnish Cancer Registry. Hospital admissions because of SMI and deaths were obtained from administrative registers. We calculated Kaplan–Meier estimates and Cox regression models to examine survival differences.ResultsWe found excess mortality in people with a history of psychotic and substance use disorders. Cancer stage and comorbidity did not explain mortality differences. Controlling for cancer treatment decreased the differences. The mortality gap between patients with psychosis and cancer patients without SMI increased over time.ConclusionsIntegrated medical and psychiatric care is needed to improve outcomes of cancer care among patients with SMI.
Work-related ill health in doctors working in Great Britain: incidence rates and trends
Authors: Zhou Anli Yue , Carder Melanie , Gittins Matthew , Agius Raymond 
Published: September 2017

BackgroundDoctors have a higher prevalence of mental ill health compared with other professional occupations but incidence rates are poorly studied.AimsTo determine incidence rates and trends of work-related ill health (WRIH) and work-related mental ill health (WRMIH) in doctors compared with other professions in Great Britain.MethodIncidence rates were calculated using an occupational physician reporting scheme from 2005–2010. Multilevel regression was use to study incidence rates from 2001 to 2014.ResultsAnnual incidence rates for WRIH and WRIMH in doctors were 515 and 431 per 100000 people employed, respectively. Higher incidence rates for WRIH and WRMIH were observed for ambulance staff and nurses, respectively. Doctors demonstrated an annual average incidence rates increase for WRIH and WRMIH, especially in women, whereas the other occupations demonstrated a decreasing or static trend. The difference in trends between the occupations was statistically significant.ConclusionsWRIH and WRMIH incidence rate are increasing in doctors, especially in women, warranting further research.