bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interface, information, interaction: a narrative review of design and functional requirements for clinical decision support
Authors: Miller Kristen , Mosby Danielle , Capan Muge , Kowalski Rebecca , Ratwani Raj , Noaiseh Yaman , Kraft Rachel , Schwartz Sanford , Weintraub William S , Arnold Ryan 
Published: September 2017

Abstract

Objective
Provider acceptance and associated patient outcomes are widely discussed in the evaluation of clinical decision support systems (CDSSs), but critical design criteria for tools have generally been overlooked. The objective of this work is to inform electronic health record alert optimization and clinical practice workflow by identifying, compiling, and reporting design recommendations for CDSS to support the efficient, effective, and timely delivery of high-quality care.

Material and Methods
A narrative review was conducted from 2000 to 2016 in PubMed and The Journal of Human Factors and Ergonomics Society to identify papers that discussed/recommended design features of CDSSs that are associated with the success of these systems.

Results
Fourteen papers were included as meeting the criteria and were found to have a total of 42 unique recommendations; 11 were classified as interface features, 10 as information features, and 21 as interaction features.

Discussion
Features are defined and described, providing actionable guidance that can be applied to CDSS development and policy. To our knowledge, no reviews have been completed that discuss/recommend design features of CDSS at this scale, and thus we found that this was important for the body of literature. The recommendations identified in this narrative review will help to optimize design, organization, management, presentation, and utilization of information through presentation, content, and function. The designation of 3 categories (interface, information, and interaction) should be further evaluated to determine the critical importance of the categories. Future work will determine how to prioritize them with limited resources for designers and developers in order to maximize the clinical utility of CDSS.

Conclusion
This review will expand the field of knowledge and provide a novel organization structure to identify key recommendations for CDSS.
Size Matters: Defining Critical in Bone Defect Size!
Authors: Schemitsch Emil H. 
Published: September 2017

Summary:
Bone defects are common and are associated with a significant burden of disease. The treatment of these injuries remains controversial, particularly those defects which are critical sized. Despite the need for decision making to be evidence based, a lack of consensus around definitions of critical-sized defects still exists, particularly around those defects in the 1–3 cm range. There is a need to define “critical” in bone defect size because noncritical defects may heal without planned reconstruction and secondary surgery. This article reviews the current evidence around the definition of a critical-sized bone defect and concludes that defects in the order of 2.5 cm or greater seem to have a poor natural history.
Segmental Bone Loss Reconstruction Using Ring Fixation
Authors: Quinnan Stephen M. 
Published: September 2017

Summary:
Ring fixation is a powerful tool in the treatment of bone defects. The ability to create high-quality, biologically normal new bone of even massive proportions using distraction osteogenesis is a major reason for its success. In addition, ring fixation provides the ability to limit the risk of deep infection, improves flexibility in limb length control and alignment, and increases soft tissue coverage options. The drawbacks of ring fixation include long frame times, pin problems, risk of joint contractures, and difficult usage in areas with a large soft tissue envelope such as the thigh. Significant advancements such as hydroxyapatite coated pins, internal cable transport, multifocal transport, and combined techniques with internal fixation have helped increase the effectiveness of ring fixator use by minimizing many of the drawbacks. At present, ring fixation provides the most effective means of treatment for large bone defects in many clinic situations.
Comparison Between Viscous Teardrops and Saline Solution to Fill Orthokeratology Contact Lenses Before Overnight Wear
Authors: Carracedo Gonzalo , Villa-Collar Cesar , Martin-Gil Alba , Serramito Maria , Santamaría Leticia 
Published: September 2017

Objective:
To compare, in terms of efficacy, the differences between the use of saline solution and a viscous artificial tear to fill the lens during the first month of orthokeratology wear.

Methods:
A pilot, double-masked, crossed, randomized, and prospective study was conducted. In this study, 20 subjects (14 males and 6 females) with a mean age of 16.29±6.22 years (range, 10–26) were fitted with orthokeratology contact lenses. For the study, nonpreserved 0.9% NaCl commercial saline solution (Avizor, Madrid, Spain) and nonpreserved artificial teardrops with 0.3% of hyaluronic acid (Ocudry 0.3%; Avizor, Madrid, Spain) were used. Corneal staining, tear break up time (TBUT), topography, refraction, visual acuity, and subjective comfort and vision with the visual analog scale (score from 0 to 10, being 10 better comfort and vision) were evaluated at 1 day, 1 week, and 1 month of contact lens wear.

Results:
The corneal staining was statistically greater in the saline group than in the Ocudry group for the first day and during 1 week of wear (P<0.05). Comfort was found to be statistically better, with Ocudry 0.3% than saline solution, being 7.17±1.94 and 6.37±1.63, for the first day, and 8.78±0.43 and 8.15±0.62 for the day 28, respectively (P<0.05). However, no differences were found for subjective vision scores, TBUT, spherical equivalent, best-corrected visual acuity and uncorrected visual acuity, and mean keratometry between groups for any visit (P>0.05).

Conclusion:
Viscous artificial tears improve the subjective comfort of patients and reduce the corneal staining, compared with saline solution during the orthokeratology lenses fitting process. However, no differences between solutions for the treatment efficacy, in vision and corneal topography, were found.
A Theory-Based and Culturally Aligned Training Program on Breast and Cervical Cancer Prevention for South Asian Community Health Workers
Authors: So Winnie K.W. , Kwong Alice N.L. , Chen Joanne M.T. , Chan Joanne C.Y. , Law Bernard M.H. , Sit Janet W.H. , Chan Carmen W.H. 
Published: September 2017

Background
Cancer screening uptake among South Asian ethnic minorities is reported to be relatively low. An outreach program, led by community health workers (CHWs), may increase the minority group’s awareness of the importance of cancer screening.

Objective
The aim of this study was to assess the feasibility and effectiveness of a theory-based, culturally sensitive program to train South Asian women in Hong Kong as CHWs.

Methods
A CHW training program, guided by the Empowerment Model and the Health Belief Model, was developed and implemented. Its feasibility was evaluated through the recruitment of South Asian women to the program and their satisfaction with it. Its effectiveness was assessed by a test of knowledge, the participants’ self-efficacy and competence, and their readiness to work as CHWs.

Results
Five South Asian women were recruited to the training program. Outcomes included increased participants’ knowledge of cancer and improved self-efficacy and competence in working as CHWs. All participants were highly satisfied with the program, although the addition of practical sessions in the South Asian community was suggested as a further improvement.

Conclusion
It seems to be feasible to train South Asian CHWs to deliver interventions to promote their peers’ awareness of breast and cervical cancer prevention, although challenges exist in recruitment of trainees. More hands-on practical opportunities as CHWs would likely increase their effectiveness.

Implications for Practice
The theoretical framework of our CHW training program and the incorporated cultural components could be useful for the development of future programs for training South Asian CHWs in delivering interventions on cancer prevention.
Single Cell RNA Sequencing of stem cell-derived retinal ganglion cells
Authors: Daniszewski Maciej , Senabouth Anne , Nguyen Quan , Crombie Duncan E. , Lukowski Samuel W. , Kulkarni Tejal , Zack Donald J , Pébay Alice , Powell Joseph E. , Hewitt Alex W. 
Published: September 2017

ABSTRACTWe used human embryonic stem cell-derived retinal ganglion cells (RGCs) to characterize the transcriptome of 1,174 cells at the single cell level. The human embryonic stem cell line BRN3B-mCherry A81-H7 was differentiated to RGCs using a guided differentiation approach. Cells were harvested at day 36 and subsequently prepared for single cell RNA sequencing. Our data indicates the presence of three distinct subpopulations of cells, with various degrees of maturity. One cluster of 288 cells upregulated genes involved in axon guidance together with semaphorin interactions, cell-extracellular matrix interactions and ECM proteoglycans, suggestive of a more mature phenotype.
Natural selection on plasticity of thermal traits in a highly seasonal environment
Authors: Bacigalupe Leonardo D. , Gaitan-Espitia Juan D. , Barria Aura M. , Gonzalez-Mendez Avia , Ruiz-Aravena Manuel , Trinder Mark , Sinervo Barry 
Published: September 2017

AbstractThis preprint has been reviewed and recommended by Peer Community In Evolutionary Biology (http://dx.doi.org/10.24072/pci.evolbiol.100048). For ectothermic species with broad geographical distributions, latitudinal/altitudinal variation in environmental temperatures (averages and extremes) are expected to shape the evolution of physiological tolerances and the acclimation capacity (i.e., degree of phenotypic plasticity) of natural populations. This can create geographical gradients of selection in which environments with greater thermal variability (e.g., seasonality) tend to favour individuals that maximize performance across a broader range of temperatures compared to more stable environments. Although thermal acclimation capacity plays a fundamental role in this context, it is unknown whether natural selection targets this trait in natural populations. Here we addressed such an important gap in our knowledge by measuring survival, through mark recapture integrated into an information-theoretic approach, as a function of the plasticity of critical thermal limits for activity, behavioural thermal preference and the thermal sensitivity of metabolism in the northernmost population of the four-eyed frogPleurodema thaul. Overall, our results indicate that thermal acclimation in this population is not being targeted by directional selection, although there might be signals of selection on individual traits. According to the most supported models, survival decreased in individuals with less tolerance to cold when cold-acclimated (probably because daily low extremes are frequent during the cooler periods of the year) and increased with body size. However, in both cases, the directional selection estimates were non-significant.
PiFlow: A Biocompatible Low-Cost Programmable Dynamic Flow Pumping System Utilizing a Raspberry Pi Zero and Commercial Piezoelectric Pumps
Authors: Kassis Timothy , Perez Paola M. , Yang Chloe J. W. , Soenksen Luis R. , Trumper David L. , Griffith Linda G. 
Published: September 2017

AbstractWith the rise of research utilizing microphysiological systems (MPSs), the need for tools that enable the physiological mimicking of the relevant cellular environment is vital. The limited ability to reproduce crucial features of the microenvironment, such as surrounding fluid flow and dynamic changes in biochemical stimuli, severely limits the types of experiments that can be carried out. Current equipment to achieve this, such as syringe and peristaltic pumps, is expensive, large, difficult to program and has limited potential for scalability. Here, we present a new pumping platform that is open-source, low-cost, modular, scalable, fully-programmable and easy to assemble that can be incorporated into cell culture systems to better recapitulate physiological environments. By controlling two commercially available piezoelectric pumps using a Raspberry Pi Zero microcontroller, the system is capable of producing arbitrary dynamic flow profiles with reliable flow rates ranging from 1 to 3,000 µL/min as specified by an easily programmable Python-based script. We validated the accuracy of the flow rates, the use of time-varying profiles, and the practicality of the system by creating repeatable dynamic concentration profiles using a 3D-printed static micromixer.
Auditory brainstem responses to continuous natural speech in human listeners
Authors: Maddox Ross K , Lee Adrian KC 
Published: September 2017

ABSTRACTSpeech is an ecologically essential signal whose processing begins in the subcortical nuclei of the auditory brainstem, but there are few experimental options for studying these early responses under natural conditions. While encoding of continuous natural speech has been successfully probed in the cortex with neurophysiological tools such as electro- and magnetoencephalography, the rapidity of subcortical response components combined with unfavorable signal to noise ratios has prevented application of those methods to the brainstem. Instead, experiments have used thousands of repetitions of simple stimuli such as clicks, tonebursts, or brief spoken syllables, with deviations from those paradigms leading to ambiguity in the neural origins of measured responses. In this study we developed and tested a new way to measure the auditory brainstem response to ongoing, naturally uttered speech. We found a high degree of morphological similarity between the speech-evoked auditory brainstem responses (ABR) and the standard click-evoked ABR, notably a preserved wave V, the most prominent voltage peak in the standard click-evoked ABR. Because this method yields distinct peaks at latencies too short to originate from the cortex, the responses measured can be unambiguously determined to be subcortical in origin. The use of naturally uttered speech to evoke the ABR allows the design of engaging behavioral tasks, facilitating new investigations of the effects of cognitive processes like language processing and attention on brainstem processing.SIGNIFICANCE STATEMENTSpeech processing is usually studied in the cortex, but it starts in the auditory brainstem. However, a paradigm for studying brainstem processing of continuous natural speech in human listeners has been elusive due to practical limitations. Here we adapt methods that have been employed for studying cortical activity to the auditory brainstem. We measure the response to continuous natural speech and show that it is highly similar to the click-evoked response. The method also allows simultaneous investigation of cortical activity with no added recording time. This discovery paves the way for studies of speech processing in the human brainstem, including its interactions with higher order cognitive processes originating in the cortex.
Interaction Between Host MicroRNAs and the Gut Microbiota in Colorectal Cancer
Authors: Yuan Ce , Burns Michael , Subramanian Subbaya , Blekhman Ran 
Published: September 2017

AbstractBackgroundAlthough variation in gut microbiome composition has been linked with colorectal cancer (CRC), the factors that mediate the interactions between CRC tumors and the microbiome are poorly understood. MicroRNAs (miRNAs) are known to regulate CRC progression and patient survival outcomes. In addition, recent studies suggested that host miRNAs can also regulate bacterial growth and influence the composition of the gut microbiome. Here, we investigated the association between miRNAs expression in human CRC tumor and normal tissues and the microbiome composition associated with these same tissues.MethodWe sequenced the small RNAs from patient-matched tumor and normal tissue samples collected from 44 human CRC patients performed an integrated analysis with microbiome taxonomic composition data from these same samples. We then interrogated the functions of the bacteria correlated with miRNAs that were differentially expressed (DE) between tumor and matched normal tissues, as well as the functions of miRNAs correlated with bacterial taxa that have been previously associated with CRC, including Fusobacterium, Providencia, Bacteroides, Akkermansia, Roseburia, Porphyromonas, and Peptostreptococcus.ResultsWe identified 76 miRNAs as DE between CRC and normal tissue, including known oncogenic miRNAs miR-182, miR-503, and miR-17∼92. These DE miRNAs were correlated with the relative abundance of several bacterial taxa, including Firmicutes, Bacteroidetes, and Proteobacteria. Bacteria correlated with DE miRNAs were enriched with distinct predicted metabolic categories. Additionally, we found that miRNAs correlated with CRC-associated bacteria are predicted to regulate targets that are relevant for host-microbiome interactions, and highlight a possible role for miRNA-driven glycan production in the recruitment of pathogenic microbial taxa.ConclusionsOur work characterized a global relationship between microbial community composition and miRNA expression in human CRC tissues. Our results support a role for miRNAs in mediating a bi-directional host-microbiome interaction in CRC. In addition, we highlight sets of potentially interacting microbes and host miRNAs, suggesting several pathways that can be targeted via future therapies.
Bcl11b is a Newly Identified Regulator of Vascular Smooth Muscle Phenotype and Arterial Stiffness
Authors: Valisno Jeff Arni C. , Elavalakanar Pavania , Nicholson Christopher , Singh Kuldeep , Avram Dorina , Cohen Richard A. , Mitchell Gary F. , Morgan Kathleen G. , Seta Francesca 
Published: September 2017

ABSTRACTB-cell leukemia 11b (Bcl11b) is a zinc-finger transcription factor known as master regulator of T lymphocytes and neuronal development during embryogenesis. Bcl11b-interacting protein COUP-TFII is required for atrial development and vasculogenesis, however a role of Bcl11b in the adult cardiovascular system is unknown. A genome-wide association study (GWAS) recently showed that a gene desert region downstream ofBCL11Band known to function asBCL11Benhancer harbors single nucleotide polymorphisms (SNPs) associated with increased arterial stiffness. Based on these human findings, we sought to examine relations between Bcl11b and arterial function using mice with Bcl11b deletion. We report for the first time that Bcl11b is expressed in vascular smooth muscle (VSM) and transcriptionally regulates the expression of VSM contractile proteins smooth muscle myosin and smooth muscle α-actin. Lack of Bcl11b in VSM-specific Bcl11b null mice (BSMKO) resulted in increased expression of Ca++-calmodulin-dependent serine/threonine phosphatase calcineurin in BSMKO VSM cells, cultured in serum-free condition, and in BSMKO aortas, which showed an inverse correlation with levels of phosphorylated VASPS239, a regulator of cytoskeletal actin rearrangements. Moreover, decreased pVASPS239in BSMKO aortas was associated with increased actin polymerization (F/G actin ratio). Functionally, aortic force, stress and wall tension, measured ex vivo in organ baths, were increased in BSMKO aortas and BSMKO mice had increased pulse wave velocity, thein vivoindex of arterial stiffness, compared to WT littermates. Despite having no effect on baseline blood pressure or angiotensin II-induced hypertension, Bcl11b deletion in VSM increased the incidence of aortic aneurysms in BSMKO mice. Aneurysmal aortas from angII-treated BSMKO mice had increased number of apoptotic VSM cells. In conclusion, we identified VSM Bcl11b as a novel and crucial regulator of VSM cell phenotype and vascular structural and functional integrity.
Efficient multi-task chemogenomics for drug specificity prediction
Authors: Playe Benoit , Azencott Chloé-Agathe , Stoven Véronique 
Published: September 2017

AbstractAdverse drug reactions, also called side effects, range from mild to fatal clinical events and significantly affect the quality of care. Among other causes, side effects occur when drugs bind to proteins other than their intended target. As experimentally testing drug specificity against the entire proteome is out of reach, we investigate the application of chemogenomics approaches. We formulate the study of drug specificity as a problem of predicting interactions between drugs and proteins at the proteome scale. We build several benchmark datasets, and proposeNN-MT, a multi-task Support Vector Machine (SVM) algorithm that is trained on a limited number of data points, in order to solve the computational issues or proteome-wide SVM for chemogenomics. We compareNN-MTto different state-of-the-art methods, and show that its prediction performances are similar or better, at an efficient calculation cost. Compared to its competitors, the proposed method is particularly efficient to predict (protein, ligand) interactions in the difficult double-orphan case, i.e. when no interactions are previously known for the protein nor for the ligand. TheNN-MTalgorithm appears to be a good default method providing state-of-the-art or better performances, in a wide range of prediction scenarii that are considered in the present study: proteome-wide prediction, protein family prediction, test (protein, ligand) pairs dissimilar to pairs in the train set, and orphan cases.
How platforms are transforming customer information management
Authors: Stone Merlin , Aravopoulou Eleni , Gerardi Gherardo , Todeva Emanuela , Weinzierl Luisa , Laughlin Paul , Stott Ryan 
Published: September 2017

Purpose
The purpose of this paper is to explain how ecosystems and platforms have evolved to manage customer information and to identify the management, research and teaching implications of this evolution.

Design/methodology/approach
This paper is based on research and industrial experience of two of the co-authors in customer relationship management, further developed with other co-authors in the field of business models, the research and teaching experience of the university authors and cross-functional literature reviews in the areas of strategy, marketing, economics, organizational behaviour and information management.

Findings
This paper shows that digitalization, cloud computing and new information-based platforms are beginning to change how customer information is being managed, creating new opportunities for improving marketing, customer relationship management and business strategy.

Research limitations/implications
The impact of platforms on the management of customer information needs to be confirmed by primary empirical research.

Practical implications
This paper identifies the need for senior marketing management to examine closely how internal and external/public customer information platforms may enhance their capability for managing customers and setting new strategic directions.

Social implications
The emergence of giant multi-sided platforms has clear implications for data protection and privacy, which need to be explored more in research.

Originality/value
This paper highlights the move to customer information platforms and identifies how senior managers should consider them as an option for better customer information management and as a basis for new business strategies.