bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase 1 study of the CXCR4 antagonist plerixafor in combination with high‐dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators’ Consortium study (POE 10‐03)
Authors: Cooper Todd M. , Sison Edward Allan Racela , Baker Sharyn D. , Li Lie , Ahmed Amina , Trippett Tanya , Gore Lia , Macy Margaret E. , Narendran Aru , August Keith , Absalon Michael J. , Boklan Jessica , Pollard Jessica , Magoon Daniel , Brown Patrick A. 
Published: April 2017

AbstractBackgroundPlerixafor, a reversible CXCR4 antagonist, inhibits interactions between leukemic blasts and the bone marrow stromal microenvironment and may enhance chemosensitivity. A phase 1 trial of plerixafor in combination with intensive chemotherapy in children and young adults with relapsed or refractory acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS) was performed to determine a tolerable and biologically active dose.ProcedurePlerixafor was administered daily for 5 days at four dose levels (6, 9, 12, and 15 mg/m2/dose) followed 4 hr later by high‐dose cytarabine (every 12 hr) and etoposide (daily).ResultsNineteen patients (13 with AML, 5 with ALL, 1 with MDS) were treated. The most common grade 3 or greater nonhematologic toxicities attributable to plerixafor were febrile neutropenia and hypokalemia. There were no dose‐limiting toxicities (DLTs). Plerixafor exposure increased with increasing dose levels and clearance was similar on days 1 and 5. Eighteen patients were evaluable for response. Two patients achieved complete remission (CR) and one patient achieved CR with incomplete hematologic recovery (CRi): all three had AML. No responses were seen in patients with ALL or MDS. Plerixafor mobilized leukemic blasts into the peripheral blood in 14 of 16 evaluable patients (median 3.4‐fold increase), and the degree of mobilization correlated with surface CXCR4 expression.ConclusionsPlerixafor, in combination with high‐dose cytarabine and etoposide, was well tolerated in children and young adults with relapsed/refractory acute leukemias and MDS. While biologic responses were observed, clinical responses in this heavily pretreated cohort were modest.
Long‐term results of the transmanubrial osteomuscular‐sparing approach for pediatric tumors
Authors: El Madi Aziz , Irtan Sabine , Sauvat Frédérique , Zérah Michel , Schleiermacher Gudrun , Galmiche‐Roland Louise , Minard‐Colin Véronique , Brisse Hervé , Sarnacki Sabine 
Published: April 2017

AbstractBackgroundThe complete and safe resection of pediatric cervicothoracic tumors, mostly represented by neurogenic tumors, remains a surgical challenge because of the complex anatomy of this region. The transmanubrial osteomuscular‐sparing approach (TOSA) is an alternative to isolated or combined cervical and thoracic approaches enabling the control of supra‐aortic vessels and nerves through the thoracic inlet.MethodsWe retrospectively reviewed the tumor characteristics, completeness of resection, morbidity, and long‐term outcome of patients with cervicothoracic tumors removed by TOSA between 2000 and 2012 in our institution.ResultsThirteen patients (7 males, 6 females) underwent surgery at a median age of 72 months (4–188) for neuroblastoma (n = 6), ganglioneuroblastoma (n = 3), rhabdoid tumor (n = 1), melanotic schwannoma (n = 1), chordoma (n = 1), and malignant peripheral nerve sheath tumor in one patient with type 1 neurofibromatosis. The median duration of the procedure was 215 minutes (110–315). Two children presented with postoperative chylothorax that resolved spontaneously. The median duration of hospitalization was 7 days (4–22). At a median follow‐up of 39 months (2–159), four patients had died of metastatic relapse (n = 2), locoregional progression (n = 1), and chemotoxicity (n = 1). The patient with melanotic schwannoma was lost to follow‐up after a local relapse at 5 months. Long‐term morbidity revealed homolateral Claude‐Bernard Horner sign and upper limb vasomotor dysfunction in disease‐free patients due to mandatory resection of the stellate ganglia.ConclusionsTOSA is a valuable surgical approach for all cervicothoracic tumors with acceptable long‐term morbidity when compared with its complexity. We can therefore recommend TOSA for tumors involving the thoracic inlet.
Mobilization patterns of children on a hematology/oncology inpatient ward
Authors: Johnston Krista , Deliva Robin , Evans Cathy 
Published: April 2017

AbstractBackgroundChildren being treated for cancer are admitted to the hospital for treatment of their disease or complications of therapy. Periods of bed rest during hospitalization can cause impairments detrimental to children with cancer who endure many side effects of therapy. Little is known about how these children mobilize while admitted to the hospital. The purpose of this study was to examine how children admitted to a hematology/oncology ward are mobilizing and analyze factors associated with delayed or infrequent mobility.ProcedureA retrospective chart review was conducted on 228 charts with data recorded on documented mobilization and referrals to physiotherapy. Primary outcome was related to mobility including timing, frequency, type, and nature of mobilization.ResultsAlmost half of children (43%) mobilized between 3 and 5 days per week, with median time to first mobilization being 2 days (interquartile range 1–3). Caregivers assisted with mobilization 91% of the time. Children isolated to their room and those reporting fever had a statistically significant decrease in the percent of admission days involving mobilization (mean difference 15 and 8%, respectively) than those not isolated and without fever. Children who were isolated also mobilized 1 day later (P = 0.016) than children who were not isolated. Percentage of time in isolation was positively correlated with timing (P = 0.04) and negatively correlated with frequency of mobilization (P < 0.001).ConclusionMost children admitted to the hospital for treatment of oncologic or hematologic conditions were noted to mobilize early, but frequency of mobilization could be improved. Periods of time in isolation appear to negatively affect mobilization.
Reduced Graphene Oxide ‐ Zinc Phthalocyanine Composites as Fascinating Material for Optoelectronic and Photocatalytic Applications
Authors: Das Poulomi , Chakraborty Koushik , Chakrabarty Sankalpita , Ghosh Surajit , Pal Tanusri 
Published: April 2017

AbstractReduced graphene oxide‐ zinc tetra tert‐butyl phthalocyanine (RGO‐ZnTTBPc) hybrid material has been synthesized through the reduction of graphene oxide (GO) in presence of ZnTTBPc. As‐prepared RGO‐ZnTTBPc thin film photodetector exhibited stable and reproducible photocurrent responses with a responsivity of 2 A/W under simulated solar light.A detailed study on electrical transport mechanism reveals the occurrence of phonon assisted quantum tunneling of charge carriers among the defect states present in RGO ‐ ZnTTBPc system. The relaxation dynamics of charge carriers in the composite is modulated by a temperature independent universal function. Furthermore, the resulting hybrid material showed an enhanced photocatalytic activity with 3.5 times higher reduction rate constant over controlled ZnTTBPc towards the reduction of 4‐nitrophenol under solar light irradiation. Superior photoresponse property and photocatalytic reduction was attributed to the synergistic effect between favorable matching of the lowest unoccupied molecular orbital (LUMO) level of ZnTTBPc to the work function of conductive RGO. The present work is especially important in the field of RGO‐based next‐generation photocatalysts and light energy harvesting applications.
Response to a mindful self‐compassion intervention in teens: A within‐person association of mindfulness, self‐compassion, and emotional well‐being outcomes
Authors: Bluth Karen , Eisenlohr‐Moul Tory A. 
Published: April 2017

ABSTRACTAs adolescence can be a stressful developmental stage, the purpose of this study was to determine if a novel mindful self‐compassion program would decrease stress, depressive symptoms, and anxiety and increase resilience, gratitude, and curiosity/exploration (positive risk‐taking), and to ascertain if mindfulness and self‐compassion co‐varied with these outcomes over time. Forty‐seven adolescents in the southeast U.S. enrolled in an 8‐week mindful self‐compassion course in five cohorts. Measures were assessed at pre‐intervention, post‐intervention, and 6‐week follow‐up. Multilevel growth analyses revealed main effects of time on perceived stress, resilience, curiosity/exploration and gratitude. Additionally, both mindfulness and self‐compassion co‐varied with perceived stress and depressive symptoms; mindfulness also co‐varied with anxiety and self‐compassion co‐varied with resilience and curiosity/exploration. Implications of these findings are that this program has potential in decreasing stress and increasing resilience and positive risk‐taking. Future studies with a control group need to be conducted to confirm these findings.
A New Battle for History in the Twenty-First Century?
Authors: Trivellato Francesca 
Published: April 2017

Abstract
This article engages with some of the questions raised by David Armitage and Jo Guldi’s “The Return of the longue durée: An Anglo-American Perspective” and their resonance among readers of the Annales. In particular, it challenges the authors’ classification of a variety of different historical studies of short periods of time under the rubric of “microhistory.” It also questions their argument that such studies are evidence of a “moral crisis” that supposedly dominated anglophone historiography from the cultural revolution of 1968 to the global financial crisis of 2008. Furthermore, the article contrasts the less conventional meanings that Fernand Braudel originally attributed to the longue durée with the ways that Armitage and Guldi interpret this expression. Finally, it asks how, in practice, historians are supposed to follow the authors’ invitation to move beyond specialized training and knowledge to produce sweeping new and original interpretations of millennia of human history.
Associations between sleep bruxism and (peri-) implant complications: a prospective cohort study
Authors: Thymi Magdalini , Visscher Corine M , Yoshida-Kohno Eiko , Crielaard Wim , Wismeijer Daniel , Lobbezoo Frank 
Published: April 2017

Abstract
Objectives/Aims:
To describe the protocol of a prospective cohort study designed to answer the question: ‘Is sleep bruxism a risk factor for (peri-)implant complications?’.

Materials and Methods:
Our study is a single-centre, double-blind, prospective cohort study with a follow-up time of 2 years. Ninety-eight participants fulfilling inclusion criteria (planned treatment with implant-supported fixed suprastructure(s) and age 18 years or older) will be included. Sleep bruxism will be monitored at several time points as masticatory muscle activity during sleep by means of a portable single-channel electromyographic device. Our main outcomes are biological complications (i.e., related to peri-implant bleeding, probing depth, marginal bone height, quality of submucosal biofilm and loss of osseointegration) and technical complications (i.e., suprastructure, abutment, implant body or other).

Results:
The study is currently ongoing, and data are being gathered.

Discussion:
The results of this prospective cohort study will provide important information for clinicians treating bruxing patients with dental implants. Furthermore, it will contribute to the body of evidence related to the behaviour of dental implants and their complications under conditions of high mechanical loadings that result from sleep bruxism activity.

Conclusion:
The protocol of a prospective cohort study designed to investigate possible associations between sleep bruxism and (peri-) implant complications was presented.
From tremella‐like MoS2 to α‐MoO3 nanoplates: sintering synthesis and adsorption properties
Authors: Cui Zhe , Sun Yangang 
Published: April 2017

A simple calcination method was explored to synthesise the tremella‐like molybdenum disulphide (MoS2), Mo trioxide (MoO3)/MoS2 and MoO3 nanoplates by using the pristine MoS2 nanosheets as the precursor. The possible formation and growth mechanism from the pristine MoS2 to the tremella‐like MoS2, MoO3/MoS2 nanoplates and MoO3 nanoplates was proposed. It was found that the calcination temperature was a key factor for the formation, ingredient and phase structure of the three samples. The adsorption properties of the three samples for an aqueous solution of methylene blue (MB) at room temperature were investigated. The results revealed that the products exhibit the better adsorption capacities with increasing the ingredient of MoO3 in the transformation process from MoS2 to MoO3. Therefore, the pure MoO3 nanoplates have the highest adsorption and removal rates, which reached 96.9% at MB concentration of 10 mg/l and 90.9% at MB concentration of 20 mg/l.
Vitronectin and Urokinase-Type Plasminogen Activator Gene Expression Levels Are Increased in Patients with Coronary Artery In-Stent Restenosis
Authors: Shafiee S. , Noorabad-Ghahroodi F. , Amirfarhangi A. , Hosseini-Fard S. , Sharifi Z. , Najafi M. 
Published: April 2017

AbstractNeointimal hyperplasia is known as a main factor contributing to in-stent restenosis (ISR). Monocytes may play a central role in vessel restenosis process after stent implantation. The aim of this study was to investigate the relationships between the urokinase-type plasminogen activator (PLAU) and vitronectin (Vtn) gene expression levels in peripheral blood mononuclear cell samples isolated from whole blood of 66 patients undergoing coronary artery angiography (22 controls, stenosis < 0.05%; 22 with stent no-restenosis and stenosis < 70%; and 22 with ISR and stenosis > 70%). The Vtn and PLAU gene expression levels were measured by real-time quantitative polymerase chain reaction technique. The age- and gender-independent increases in the expression levels of Vtn (17-fold; p < 0.001) and PLAU (27-fold; p < 0.0001) genes were found in the patients with ISR as compared with the control group. The results suggested that the Vtn and PLAU genes may be involved in the coronary artery ISR.
ClusPro PeptiDock: efficient global docking of peptide recognition motifs using FFT
Authors: Porter Kathryn A , Xia Bing , Beglov Dmitri , Bohnuud Tanggis , Alam Nawsad , Schueler-Furman Ora , Kozakov Dima 
Published: April 2017

Abstract

Summary
We present an approach for the efficient docking of peptide motifs to their free receptor structures. Using a motif based search, we can retrieve structural fragments from the Protein Data Bank (PDB) that are very similar to the peptide’s final, bound conformation. We use a Fast Fourier Transform (FFT) based docking method to quickly perform global rigid body docking of these fragments to the receptor. According to CAPRI peptide docking criteria, an acceptable conformation can often be found among the top-ranking predictions.

Availability and Implementation
The method is available as part of the protein-protein docking server ClusPro at https://peptidock.cluspro.org/nousername.php.

Supplementary information
Supplementary data are available at Bioinformatics online.
Endogenous fishing mortalities: a state-space bioeconomic model
Authors: Da-Rocha José-María , García-Cutrín Javier , Gutiérrez María-José , Jardim Ernesto 
Published: April 2017

Abstract
A methodology that endogenously determines catchability functions that link fishing mortality with contemporaneous stock abundance is presented. We consider a stochastic age-structured model for a fishery composed by a number of fishing units (fleets, vessels or métiers) that optimally select the level of fishing effort to be applied considering total mortalities as given. The introduction of a balance constrain which guarantees that total mortality is equal to the sum of individual fishing mortalities optimally selected, enables total fishing mortality to be determined as a combination of contemporaneous abundance and stochastic processes affecting the fishery. In this way, future abundance can be projected as a dynamic system that depends on contemporaneous abundance. The model is generic and can be applied to several issues of fisheries management. In particular, we illustrate how to apply the methodology to assess the floating band target management regime for controlling fishing mortalities which is inspired in the new multi-annual plans. Our results support this management regime for the Mediterranean demersal fishery in Northern Spain.
Long-Term Impacts of Orthokeratology Treatment on Sub-Basal Nerve Plexus and Corneal Sensitivity Responses and Their Reversibility
Authors: Nombela-Palomo María , Felipe-Marquez Gema , Teus Miguel Angel , Hernandez-Verdejo Jose Luis , Nieto-Bona Amelia 
Published: April 2017

Purpose:
To examine the effects of one year of overnight orthokeratology (OK) treatment on the sub-basal nerve plexus (SBNP) and corneal sensitivity and to assess the reversibility of these effects one month after treatment interruption.

Methods:
Thirty-two subjects with low-moderate myopia underwent OK treatment for one year. Fifteen non-contact lens wearers served as controls. At the time points baseline, one year of treatment, and one month after removing the OK lenses, two tests were conducted: corneal sensitivity (Cochet–Bonnet esthesiometer) and SBNP imaging by in vivo confocal microscopy.

Results:
In participants wearing OK lenses, significant reductions over the year were produced in SBNP nerve density (P=0.001 and P=0.006) and number of nerves (P<0.001 and P=0.001) in the central and mid-peripheral cornea, respectively. Differences over the year were also detected in central objective tortuosity (P=0.002). After lens removal, baseline values of nerve density (P=0.024 and P=0.001) and number of nerves (P=0.021 and P<0.001) for the central and mid-peripheral cornea, respectively, were not recovered. At one month post-treatment, a difference was observed from one-year values in central corneal sensitivity (P=0.045) and mid-peripheral Langerhans cell density (P=0.033), and from baseline in mid-peripheral objective tortuosity (P=0.049). Direct correlation was detected at one year between nerve density and tortuosity both in the central (P<0.01; r=0.69) and mid-peripheral cornea (P<0.01; r=0.76).

Conclusions:
Long-term OK treatment led to reduced SBNP nerve density and this was directly correlated with corneal tortuosity. After one month of treatment interruption, nerve density was still reduced.
Evaluated Conjunctival Blood Flow Velocity in Daily Contact Lens Wearers
Authors: Shi Yingying , Hu Liang , Chen Wan , Qu Dongyi , Jiang Hong , Wang Jianhua 
Published: April 2017

Objective:
This study examined conjunctival microvasculature development in long-term habitual contact lens (HCL) wearers after a night of sleep.

Methods:
Twenty HCL wearers (15 women and 5 men, aged 28.6±6.9 years, mean age±standard deviation) who had worn contact lenses on a daily basis for at least 3 years and 40 noncontact lens (NCL) wearers (23 women and 17 men, aged 36.5±6.6 years, mean age±standard deviation) participated in the study. A functional slitlamp biomicroscopy imaging system was used to image the temporal bulbar conjunctiva. Imaging was performed in the morning while the contact lens wearers were not wearing their lenses after a night of sleep. The conjunctival vessel diameters, blood flow velocities, and flow rates were measured. In addition, fractal analyses were performed to obtain the vessel network density (Dbox) and complexity (D0).

Results:
The average blood flow velocity in HCL wearers after a night of sleep was 0.59±0.19 mm/s, which was significantly higher than that in NCL wearers (0.48±0.17 mm/s, P<0.05). The microvessel network density and complexity levels (Dbox=1.64±0.05 and D0=1.71±0.05, respectively) in the HCL wearers were significantly higher than those in NCL wearers (Dbox=1.61±0.05 and D0=1.69±0.04, both P<0.05). The blood flow velocity was positively correlated with the duration of contact lens wear (r=0.46, P<0.05) and with the daily number of lens-wearing hours (r=0.49, P<0.05) in HCL wearers.

Conclusions:
This study identified microvascular alterations in the conjunctiva in response to daily contact lens wear after a night of sleep in long-term daily contact lens wearers. The unrecovered changes may indicate that para-inflammation occurs on ocular surfaces because of contact lens wear and that overnight sleeping with no lenses may not sufficiently restore the ocular surface to an intact state.
Water Exposure is a Common Risk Behavior Among Soft and Gas-Permeable Contact Lens Wearers
Authors: Zimmerman Aaron B. , Richdale Kathryn , Mitchell Gladys Lynn , Kinoshita Beth T. , Lam Dawn Y. , Wagner Heidi , Sorbara Luigina , Chalmers Robin L. , Collier Sarah A. , Cope Jennifer R. , Rao Maya M. , Beach Michael J. , Yoder Jonathan S. 
Published: April 2017

Purpose:
To understand soft contact lens (SCL) and gas-permeable (GP) lens wearers' behaviors and knowledge regarding exposure of lenses to water.

Methods:
The Contact Lens Risk Survey (CLRS) and health behavior questions were completed online by a convenience sample of 1056 SCL and 85 GP lens wearers aged 20 to 76 years. Participants were asked about exposing their lenses to water and their understanding of risks associated with these behaviors. Chi-square analyses examined relationships between patient behaviors and perceptions.

Results:
GP lens wearers were more likely than SCL wearers to ever rinse or store lenses in water (rinsing: 91% GP, 31% SCL, P < 0.001; storing: 33% GP, 15% SCL P < 0.001). Among SCL wearers, men were more likely to store (24% vs. 13%, P = 0.003) or rinse (41% vs. 29%, P = 0.012) their lenses in water. Showering while wearing lenses was more common in SCL wearers (86%) than GP lens wearers (67%) (P < 0.0001). Swimming while wearing lenses was reported by 62% of SCL wearers and 48% of GP lens wearers (P = 0.027). Wearers who rinsed (SCL; P < 0.0001, GP; P = 0.11) or stored lenses in water (SCL; P < 0.0001, GP P = 0.007) reported that this behavior had little or no effect on their infection risk, compared with those who did not. Both SCL (P < 0.0001) and GP lens wearers (P < 0.0001) perceived that distilled water was safer than tap water for storing or rinsing lenses.

Conclusions:
Despite previously published evidence of Acanthamoeba keratitis' association with water exposure, most SCL, and nearly all GP lens wearers, regularly expose their lenses to water, with many unaware of the risk.