bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability‐preserving model order reduction for time‐domain simulation of vibro‐acoustic FE models
Authors: van de Walle A. , Naets F. , Deckers E. , Desmet W. 
Published: June 2016

SummaryThis work proposes novel stability‐preserving model order reduction approaches for vibro‐acoustic finite element models. As most research in the past for these systems has focused on noise attenuation in the frequency‐domain, stability‐preserving properties were of low priority. However, as the interest for time‐domain auralization and (model based) active noise control increases, stability‐preserving model order reduction techniques are becoming indispensable. The original finite element models for vibro‐acoustic simulation are already well established but require too much computational load for these applications. This work therefore proposes two new global approaches for the generation of stable reduced‐order models. Based on proven conditions for stability preservation under one‐sided projection, a reformulation of the displacement‐fluid velocity potential (u − ϕ) formulation is proposed. In contrast to the regular formulation, the proposed approach leads to a new asymmetric structure for the system matrices which is proven to preserve stability under one‐sided projection. The second approach starts from a displacement‐pressure (u − p) description where the system level projection space is decoupled for the two domains, for which we also prove the preservation of stability. Two numerical validation cases are presented which demonstrate the inadequacy of straightforward model order reduction on typical vibro‐acoustic models for time‐domain simulation and compare the performance of the proposed approaches. Both proposed approaches effectively preserve the stability of the original system. Copyright © 2016 John Wiley & Sons, Ltd.
Intrinsic local destabilization of the C‐terminus predisposes integrin α1 I domain to a conformational switch induced by collagen binding
Authors: Nunes Ana Monica , Zhu Jie , Jezioro Jacqueline , Minetti Conceição A.S.A. , Remeta David P. , Farndale Richard W. , Hamaia Samir W. , Baum Jean 
Published: June 2016

AbstractIntegrin–collagen interactions play a critical role in a myriad of cellular functions that include immune response, and cell development and differentiation, yet their mechanism of binding is poorly understood. There is increasing evidence that conformational flexibility assumes a central role in the molecular mechanisms of protein–protein interactions and here we employ NMR hydrogen–deuterium exchange (HDX) experiments to explore the impact of slower timescale dynamic events. To gain insight into the mechanisms underlying collagen‐induced conformational switches, we have undertaken a comparative study between the wild type integrin α1 I and a gain‐of‐function E317A mutant. NMR HDX results suggest a relationship between regions exhibiting a reduced local stability in the unbound I domain and those that undergo significant conformational changes upon binding. Specifically, the αC and α7 helices within the C‐terminus are at the center of such major perturbations and present reduced local stabilities in the unbound state relative to other structural elements. Complementary isothermal titration calorimetry experiments have been performed to derive complete thermodynamic binding profiles for association of the collagen‐like triple‐helical peptide with wild type α1 I and E317A mutant. The differential energetics observed for E317A are consistent with the HDX experiments and support a model in which intrinsically destabilized regions predispose conformational rearrangement in the integrin I domain. This study highlights the importance of exploring different timescales to delineate allosteric and binding events.
Mining from distributed and abstracted data
Authors: Zhang Xiaofeng , Cheung William K. , Ye Yunming 
Published: June 2016

Discovering global knowledge from distributed data sources is challenging as there exist several practical concerns such as bandwidth limitation and data privacy. By appropriately abstracting distributed data, various global data mining tasks could still be implemented on the basis of local data abstractions. This article reviews existing techniques related to distributed data mining in abstraction‐based data mining. It then discusses open research challenges on mining tasks performed on distributed and abstracted data, describes how global data models (clustering and manifold discovery) could be learnt based on local data models, and points out future research directions. WIREs Data Mining Knowl Discov 2016, 6:167–176. doi: 10.1002/widm.1182This article is categorized under:

Technologies > Computer Architectures for Data Mining
Technologies > Structure Discovery and Clustering
Technologies > Visualization
Improved ethyl caproate production of Chinese liquor yeast by overexpressing fatty acid synthesis genes with OPI1 deletion
Authors: Chen Yefu , Luo Weiwei , Gong Rui , Xue Xingxiang , Guan Xiangyu , Song Lulu , Guo Xuewu , Xiao Dongguang 
Published: June 2016

Abstract
During yeast fermentation, ethyl esters play a key role in the development of the flavor profiles of Chinese liquor. Ethyl caproate, an ethyl ester eliciting apple-like flavor, is the characteristic flavor of strong aromatic liquor, which is the best selling liquor in China. In the traditional fermentation process, ethyl caproate is mainly produced at the later fermentation stage by aroma-producing yeast, bacteria, and mold in a mud pit instead of Saccharomyces cerevisiae at the expense of grains and fermentation time. To improve the production of ethyl caproate by Chinese liquor yeast (S. cerevisiae) with less food consumption and shorter fermentation time, we constructed three recombinant strains, namely, α5-ACC1ΔOPI1, α5-FAS1ΔOPI1, and α5-FAS2ΔOPI1 by overexpressing acetyl-CoA carboxylase (ACC1), fatty acid synthase 1 (FAS1), and fatty acid synthase 2 (FAS2) with OPI1 (an inositol/choline-mediated negative regulatory gene) deletion, respectively. In the liquid fermentation of corn hydrolysate, the contents of ethyl caproate produced by α5-ACC1ΔOPI1, α5-FAS1ΔOPI1, and α5-FAS2ΔOPI1 increased by 0.40-, 1.75-, and 0.31-fold, correspondingly, compared with the initial strain α5. The contents of other fatty acid ethyl esters (FAEEs) (C8:0, C10:0, C12:0) also increased. In comparison, the content of FAEEs produced by α5-FAS1ΔOPI1 significantly improved. Meanwhile, the contents of acetyl-CoA and ethyl acetate were enhanced by α5-FAS1ΔOPI1. Overall, this study offers a promising platform for the development of pure yeast culture fermentation of Chinese strong aromatic liquor without the use of a mud pit.
Endophytic Streptomyces sp. AC35, a producer of bioactive isoflavone aglycones and antimycins
Authors: Ondrejíčková P , Šturdíková M , Hushegyi A , Švajdlenka E , Markošová K , Čertík M 
Published: June 2016

Abstract
In this research, a microbial endophytic strain obtained from the rhizosphere of the conifer Taxus baccata and designated as Streptomyces sp. AC35 (FJ001754.1 Streptomyces, GenBank) was investigated. High 16S rDNA gene sequence similarity suggests that this strain is closely related to S. odorifer. The major fatty acid profile of intracellular lipids was also carried out to further identify this strain. Atomic force microscopy and scanning acoustic microscopy were used to image our strain. Its major excreted substances were extracted, evaluated for antimicrobial activity, purified, and identified by ultraviolet–visible spectroscopy (UV–vis), liquid chromatography–mass spectrometry (LC–MS/MS) and nuclear magnetic resonance as the bioactive isoflavone aglycones—daidzein, glycitein and genistein. Batch cultivation, performed under different pH conditions, revealed enhanced production of antimycin components when the pH was stable at 7.0. Antimycins were detected by HPLC and identified by UV–vis and LC–MS/MS combined with the multiple reaction monitoring. Our results demonstrate that Streptomyces sp. AC35 might be used as a potential source of effective, pharmaceutically active compounds.
Development of a New Graduate Perioperative Nursing Program at an Urban Pediatric Institution
Authors: Gorgone Pamela D. , Arsenault Loretta , Milliman‐Richard Yolanda J. , Lajoie Debra L. 
Published: June 2016

AbstractIn 2012, perioperative personnel from Boston Children's Hospital began the process of planning for perioperative staff member attrition and retirement by developing a new graduate perioperative nursing program geared toward our pediatric urban academic institution. We selected two cohorts of new graduate nurses to begin the program in 2013. To date, two cohorts of six graduate nurses have completed the program and have been hired. Our new perioperative nurse retention rate is 100%. All of these nurses are currently practicing in the main OR at our facility. In one year, we recovered the initial program costs, which included the expenses incurred by hiring 12 full‐time employees to replace more highly paid tenured RNs lost to attrition or retirement and training costs for new graduates. We believe the program has reduced overall long‐term staffing costs and has prevented disruption to services as a result of unexpected vacancies from retirements and resignations.
Anti‐parkinsonian effects of fluvoxamine maleate in maternally separated rats
Authors: Dallé Ernest , Daniels Willie M.U. , Mabandla Musa V. 
Published: June 2016

AbstractExposure to early life stress has been shown to result in anxiety‐like symptoms and exacerbates degeneration of dopaminergic neurons in a rat model of Parkinson's disease (PD). First line treatment for anxiety disorders includes the use of Fluvoxamine maleate (FM). In this study, we investigated whether treating anxiety‐like symptoms with FM has an effect in alleviating the neurotoxic effects of 6‐OHDA in a parkinsonian rat model. Early maternal separation was used to create a rat model that depicts anxiety‐like symptoms. Maternally separated adult Sprague‐Dawley rats were treated with FM prior to and following lesion with 6‐hydroxydopamine (6‐OHDA). The elevated plus‐maze (EPM) and the forelimb akinesia tests were used to evaluate anxiety‐like symptoms and motor impairment respectively. Blood plasma was used to measure corticosterone concentration, and striatal tissue was collected for dopamine (DA) and serotonin (5‐HT) analysis. Our results show that animals exposed to early life stress displayed increased anxiety‐like symptoms and elevated basal plasma corticosterone concentration which were attenuated by treatment with FM. A 6‐OHDA lesion effect was evidenced by impairment in the forelimb akinesia test as well as decreased DA and 5‐HT concentrations in the lesioned striatum. These effects were attenuated on DA neurons by FM treatment in the pre‐lesion treated as opposed to the post‐lesion treated rats. This study suggests that early treatment of anxiety‐like behavior decreases the vulnerability of DA neurons to neurotoxic insults later in life thus slowing down DA degeneration in PD.
A recipe for friendship: Similar food consumption promotes trust and cooperation
Authors: Woolley Kaitlin , Fishbach Ayelet 
Published: June 2016

AbstractThis research examines the consequences of incidental food consumption for trust and cooperation. We find that strangers who are assigned to eat similar (vs. dissimilar) foods are more trusting of each other in a trust game (Study 1). Food consumption further influences conflict resolution, with strangers who are assigned to eat similar foods cooperating more in a labor negotiation, and therefore earning more money (Study 2). The role of incidental food similarity on increased trust extends to the product domain. Consumers are more trusting of information about non‐food products (e.g., a software product) when the advertiser in the product testimonial eats similar food to them (Study 3). Lastly, we find evidence that food serves as a particularly strong cue of trust compared with other incidental similarity. People perceive that pairs eating similar foods, but not pairs wearing similar colored shirts, are more trusting of one another (Study 4). We discuss theoretical and practical implications of this work for improving interactions between strangers, and for marketing products.
Development of complementary feeding recommendations for 12–23-month-old children from low and middle socio-economic status in West Java, Indonesia: contribution of fortified foods towards meeting the nutrient requirement
Authors: Fahmida Umi , Santika Otte 
Published: June 2016

AbstractInadequate nutrient intake as part of a complementary feeding diet is attributable to poor feeding practices and poor access to nutritious foods. Household socio-economic situation (SES) has an influence on food expenditure and access to locally available, nutrient-dense foods and fortified foods. This study aimed to develop and compare complementary feeding recommendations (CFR) for 12–23-month-old children in different SES and evaluate the contribution of fortified foods in meeting nutrient requirements. A cross-sectional survey was conducted in low and medium SES households (n 114/group) in urban Bandung district, West Java province, Indonesia. Food pattern, portion size and affordability were assessed, and CFR were developed for the low SES (LSES) and middle SES (MSES) using a linear programming (LP) approach; two models – with and without fortified foods – were run using LP, and the contribution of fortified foods in the final CFR was identified. Milk products, fortified biscuits and manufactured infant cereals were the most locally available and consumed fortified foods in the market. With the inclusion of fortified foods, problem nutrients were thiamin in LSES and folate and thiamin in MSES groups. Without fortified foods, more problem nutrients were identified in LSES, that is, Ca, Fe, Zn, niacin and thiamin. As MSES consumed more fortified foods, removing fortified foods was not possible, because most of the micronutrient-dense foods were removed from their food basket. There were comparable nutrient adequacy and problem nutrients between LSES and MSES when fortified foods were included. Exclusion of fortified foods in LSES was associated with more problem nutrients in the complementary feeding diet.
The Severity of Symptoms Related to Irritable Bowel Syndrome is a Risk Factor for the Misclassification of Significant Organic Disease
Authors: Carter Dan , Beer-Gabel Marc , Derazne Estela , Tzur Dorit , Bardan Eytan 
Published: June 2016

Background and Aims:
The diagnosis of irritable bowel syndrome (IBS) is based mainly on clinical evaluation. The reported incidence of misclassification of significant organic diseases in previously diagnosed IBS patients differs between studies. The aim of this study was to examine the incidence and risk factors for the misclassification of significant organic disease [colon cancer, inflammatory bowel disease (IBD), Celiac disease, and thyroid dysfunction] in a cohort of young patients with symptoms attributed to IBS.

Methods:
In this population-based cohort study, we examined the incidence and risk factors for the diagnosis of a new significant organic diseases in a cohort of 2645 IBS patients.

Results:
During follow-up, organic disease was diagnosed in 27 subjects (1.03%): IBD in 23, Celiac disease in 2, IBD and Celiac disease in 1, and hypothyroidism in1. The mean interval from the diagnosis of IBS to the diagnosis of an organic disorder was 13.08±8.51 months. Increased symptom severity was the only significant risk factor for the misclassification of an organic disease (hazard ratio, 2.26; 95% confidence interval, 1.01-5.05; P=0.047). The risk ratio for misclassification of organic diseases in moderate to severe IBS was increased by 2.575 (95% confidence interval, 1.10-6.51; P=0.027) as compared with mild IBS.

Conclusions:
The incidence of misclassification of major organic disease in IBS patients was low. Increased symptoms severity was the only significant risk factor for the misclassification of organic disorders. Further gastrointestinal evaluation should be considered in patients with moderate to severe symptoms attributed to IBS.
A Comparison of Bilateral Side-by-Side Metal Stents Deployed Above and Across the Sphincter of Oddi in the Management of Malignant Hilar Biliary Obstruction
Authors: Cosgrove Natalie , Siddiqui Ali A. , Adler Douglas G. , Shahid Haroon , Sarkar Avik , Sharma Ashish , Kowalski Thomas E. , Loren David , Warndorf Matthew , Chennat Jennifer , Munigala Satish , Papachristou Georgios I. 
Published: June 2016

Background and Aims:
The optimal method for endoscopic placement of bilateral self-expanding metal stents (SEMS) for the management of malignant hilar biliary obstruction has not been determined. The aim of this study was to compare the efficacies and complication rates between SEMS placed above and across the sphincter of Oddi (SO) in patients with malignant hilar biliary obstruction.

Materials and Methods:
A retrospective review of patients with malignant hilar strictures who underwent bilateral SEMS placement at 3 centers was performed. Patients were divided into 2 groups: group A (above SO, n=52) or B (across SO, n=120). Patient demographics, technical success (successful SEMS placement across the stricture), functional success (decrease in pretreatment bilirubin level), complications, stent occlusion, and patient survival in the 2 groups were evaluated.

Results:
We identified 172 patients with malignant hilar biliary obstruction (106 males, mean age 67 y). Significantly more early complications (1.9% vs. 11.7%, P=0.04) were seen in group B, mainly post-endoscopic retrograde cholangio-pancreatography pancreatitis. Mean SEMS patency periods were 33 weeks for group A and 29.6 weeks for group B (P=0.3). Occlusion rates were 50% and 45% for groups A and B (P=0.61); occlusion was due to tumor in-growth or overgrowth in all patients. SEMS occlusion was successfully treated endoscopically in 85% (22/26) patients in group A and 96% (52/54) in group B (P=0.24). The median survival time was 26 weeks in the group A and 29 weeks in group B (P=0.49).

Discussion:
Bilateral side-by-side SEMS placement above or below the SO results in similar success rates, stent patency duration, and stent occlusion rates. Significantly fewer complications, with a trend toward lower rates of pancreatitis, were observed for SEMS placed above the SO.
Randomized clinical trial: efficacy of a food supplement, TRANSITECH, on healthy individuals with mild intermittent constipation
Authors: Alexandre Virginie , Bertin Claire , Boubaya Marouane , Airinei Gheorghe , Bouchoucha Michel , Benamouzig Robert 
Published: June 2016

Background
Constipation is a common disorder in the general population and can be observed in healthy individuals. A natural product leading to an increase in bowel movements and decrease in colonic transit time (CTT), without bloating, could be useful for the patient’s care.

Objectives
To investigate the effects of TRANSITECH, a food supplement composed of plants and lactic ferments, on bowel movements, CTT and bloating.

Methods
A total of 100 healthy participants, presenting two to five stools per week, were selected and followed over a 6-day baseline period. They were randomly assigned to receive daily two tablets of TRANSITECH or placebo during 10 days. They were then followed up over 28 days after intervention. Participants daily recorded in a home questionnaire the characteristics of stools (frequency and consistency), and the importance of bloating during the preintervention period (from D–6 to D0), the intervention period (from D0 to D10) and the postintervention period (from D10 to D38). Their CTTs were also evaluated by following the propagation of radiopaque markers at D0 and D10.

Results
At D10, the food supplement group showed, compared with the placebo group, higher daily stool emission (0.95±0.50, 0.70±0.20, P<0.001), softer stool consistency (2.5±0.6 vs. 3.0±0.8, P<0.001) and lower CTT (33.8±28.2 vs. 56.4±36.2 h, P=0.01). The active group also showed a sustained increase in daily stool emissions observed at D38 compared with D0 (P=0.03).

Conclusion
TRANSITECH is an efficient natural solution for the treatment of constipation. It increases the number of bowel movements, decreases the oroanal and segmental CTT, is well tolerated, and presents sustained effects after treatment completion.
Etiology of Diarrhea, Nutritional Outcomes, and Novel Intestinal Biomarkers in Tanzanian Infants
Authors: Gosselin Kerri B. , Aboud Said , McDonald Christine M. , Moyo Sabrina , Khavari Nasim , Manji Karim , Kisenge Rodrick , Fawzi Wafaie , Kellogg Mark , Tran Hao Q. , Kibiki Gibson , Gratz Jean , Liu Jie , Gewirtz Andrew , Houpt Eric , Duggan Christopher 
Published: June 2016

ABSTRACTObjective:Diarrheal diseases are a leading cause of morbidity and mortality worldwide, but the etiology of diarrhea and its relation to nutritional outcomes in resource‐limited settings is poorly defined. We sought to determine the etiology of community‐acquired diarrhea in Tanzanian infants and to assess the association with anthropometrics and novel intestinal biomarkers.Methods:A convenience sample of infants in a trial of zinc and/or multivitamin supplementation in Tanzania was selected. Subjects were enrolled at age 6 weeks and studied for 18 months. Stool samples were obtained from children with acute diarrhea. A novel, polymerase chain reaction‐based TaqMan array was used to screen stool for 15 enteropathogens. A subset of subjects had serum gastrointestinal biomarkers measured.Results:One hundred twenty‐three subjects with diarrhea were enrolled. The mean ± SD age at stool sample collection was 12.4 ± 3.9 months. Thirty‐five enteropathogens were identified in 34 (27.6%) subjects: 11 rotavirus, 9 Cryptosporidium spp, 7 Shigella spp, 3 Campylobacter jejuni/coli, 3 heat stable‐enterotoxigenic Escherichia coli, and 2 enteropathogenic E coli. Subjects with any identified enteropathogen had significantly lower weight‐for‐length z scores (−0.55 ± 1.10 vs 0.03 ± 1.30, P = 0.03) at the final clinic visit than those without an identified pathogen. Fifty of the 123 subjects (40.7%) had serum analyzed for antibodies to lipopolysaccharide (LPS) and flagellin. Subjects with any identified enteropathogen had lower immunoglobulin (IgA) antibodies to LPS (0.75 ± 0.27 vs 1.13 ± 0.77, P = 0.01) and flagellin (0.52 ± 0.16 vs 0.73 ± 0.47, P = 0.02) than those without an identified pathogen.Conclusions:This quantitative polymerase chain reaction method may allow identification of enteropathogens that place children at higher risk for suboptimal growth. IgA anti‐LPS and flagellin antibodies hold promise as emerging intestinal biomarkers.
Protein Malnutrition During Juvenile Age Increases Ileal and Colonic Permeability in Rats
Authors: Eyzaguirre‐Velásquez Johana , Olavarría‐Ramírez Loreto , González‐Arancibia Camila , Díaz‐Merino Camila , Ariz Raúl , López Silvana , Quiroz Waldo , Beltrán Caroll J. , Bravo Javier A. , Julio‐Pieper Marcela 
Published: June 2016

ABSTRACTProtein malnutrition can lead to morphological and functional changes in jejunum and ileum, affecting permeability to luminal contents. Regarding the large intestine, data are scarce, especially at juvenile age. We investigated whether low‐protein (LP) diet could modify ileal and colonic permeability and epithelial morphology in young rats. Isocaloric diets containing 26% (control diet) or 4% protein were given to male rats between postnatal days 40 and 60. LP‐diet animals failed to gain weight and displayed decreased plasma zinc levels (a marker of micronutrient deficiency). In addition, transepithelial electrical resistance and occludin expression were reduced in their ileum and colon, indicating increased gut permeability. Macromolecule transit was not modified. Finally, LP diet induced shortening of colonic crypts without affecting muscle thickness. These data show that protein malnutrition increases not only ileum but also colon permeability in juvenile rats. Enhanced exposure to colonic luminal entities may be an additional component in the pathophysiology of protein malnutrition.