bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Well‐Coupled Supramolecular System Accelerates Photophosphorylation
Authors: Li Zibo , Yu Fanchen , Wang Shuhao , Cai Yuyang , Xu Yang , Li Yue , Fei Jinbo , Li Junbai 
Published: September 2024

AbstractSupramolecular assembly allows multiple chemical/bio‐components integrated as one system for cascade biochemical reactions. Herein the graphitic carbon nitrides (g‐C3N4) as photocatalyst trapped in a dipeptide hydrogel covering adenosine triphosphate (ATP) synthase accelerates the photophosphorylation through ATP synthesis. Self‐assembled N‐fluorenylmethoxycarbonyl diphenylalanine (Fmoc‐FF) as nanofibrils to allow g‐C3N4 nanosheets are embedded as a complex Fmoc‐FF/g‐C3N4 hydrogel. Fmoc‐FF gel exhibits good electronic coupling with g‐C3N4, which enables a photo‐induced proton generation. The transmembrane proton gradient can be established by ATP synthase‐lipid reconstituted on the surface of the Fmoc‐FF/g‐C3N4 hydrogel to enhance the ATP synthesis. It indicates that the Fmoc‐FF/g‐C3N4/ATP synthase‐lipid film can possess a longer‐term ATP production capability and allow repeated immersion for sustained ATP production. Such a hydrogel‐supported ATP synthesis platform is achieved by a procedure at a larger scale.
Anion‐Anchored Polymer‐in‐Salt Solid Electrolyte for High‐Performance Zinc Batteries
Authors: Shi Xueru , Zhong Yunpeng , Yang Yongqiang , Zhou Jiang , Cao Xinxin , Liang Shuquan 
Published: September 2024

AbstractSolid polymer electrolytes hold promise for addressing key challenges in rechargeable zinc batteries (ZBs) utilizing aqueous electrolytes. However, achieving simultaneous high ionic conductivity, excellent mechanical strength, and a high cation transference number while effectively suppressing Zn dendrites remains challenging. Herein, we design a novel polymer‐in‐salt solid electrolyte (PISSE) composed of polyacrylonitrile (PAN), zinc chloride (ZnCl2), and niobium pentoxide with oxygen vacancies (Nb2O5‐x) with high ionic conductivity. PAN polymer matrix provides the electrolyte good mechanical properties and solubility of Zn salt. The high concentration of ZnCl2 effectively decouples the Zn2+ from polymer chain segments and provides more ionic conduction amorphous region. Moreover, incorporating Nb2O5‐x filler accelerates Zn2+ desolvation by anchoring (ZnxCly)2x–y clusters and enhances the system's mechanical properties, achieving a superior Zn2+ transference number (~0.93) and interfacial stability. Consequently, the optimized PISSE demonstrates exceptional stability during prolonged cycling periods, wide temperature range operation (−40 °C to 60 °C), remarkable flexibility, and compatibility with diverse electrode materials. This study provides valuable insights into the design of solid‐state electrolytes based on ZBs and elucidates their multifunctional prospects.
Synergistic Regulation of Anode and Cathode Interphases via an Alum Electrolyte Additive for High‐Performance Aqueous Zinc‐Vanadium Batteries
Authors: He Lingjun , Lin Chuyuan , Zeng Lingxing , Xiao Fuyu , Lin Hui , Xiong Peixun , Qian Qingrong , Chen Qinghua , Yan Zhenhua , Chen Jun 
Published: September 2024

AbstractA zinc (Zn) metal anode paired with a vanadium oxide (VOx) cathode is a promising system for aqueous Zn–ion batteries (AZIBs); however, side reactions proliferating on the Zn anode surface and the infinite dissolution of the VOx cathode destabilise the battery system. Here, we introduce a multi‐functional additive into the ZnSO4 (ZS) electrolyte, KAl(SO4)2 (KASO), to synchronise the in situ construction of the protective layer on the surface of the Zn anode and the VOx cathode. Theoretical calculations and synchrotron radiation have verified that the high‐valence Al3+ plays dual roles of competing with Zn2+ for solvation and forming a Zn−Al alloy layer with a homogeneous electric field on the anode surface to mitigate the side reactions and dendrite generation. The Al‐containing cathode–electrolyte interface (CEI) considerably alleviates the irreversible dissolution of the VOx cathode and the accumulation of byproducts. Consequently, the Zn||Zn cell with KASO exhibits an ultra‐long cycle of 6000 h at 2 mA cm−2. Importantly, the VOx cathodes (VO2, V2O5 and NH4V4O10) in the ZS−KASO electrolyte showed excellent cycling stability, including Zn powder||VO2 cells and Zn||VO2 pouch cells. Even better, the full cell exhibits excellent cycling stability at low negative/positive (N/P) ratio of 2.83 and high mass loading (~16 mg cm−2). This study offers a straightforward and practical reference for concurrently addressing challenges at the anode and cathode of AZIBs.
Self‐Assembled Antibody‐Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides
Authors: Zhou Liujuan , Bi Jie , Chang Shenghai , Bai Zhaoshuai , Yu Junqi , Wang Ruru , Li Zhihang , Zhang Xing , Chou James J. , Pan Liqiang 
Published: September 2024

AbstractAntibody‐oligonucleotide conjugate (AOC) affords preferential cell targeting and enhanced cellular uptake of antisense oligonucleotide (ASO). Here, we have developed a modular AOC (MAOC) approach based on accurate self‐assembly of separately prepared antibody and ASO modules. Homogeneous multimeric AOC with defined ASO‐to‐antibody ratio were generated by L–DNA scaffold mediated precise self‐assembly of antibodies and ASOs. The MAOC approach has been implemented to deliver exon skipping ASOs via transferrin receptor (TfR1) mediated internalization. We discovered an anti‐TfR1 sdAb that can greatly enhance nuclear delivery of ASOs. Cryo‐EM structure of the sdAb‐TfR1 complex showed a new epitope that does not overlap with the binding sites of endogenous TfR1 ligands. In vivo functional analyses of MAOCs with one ASO for single exon skipping and two ASOs for double exon skipping showed that both ASO concentration and exon skipping efficacy of MAOC in cardiac and skeletal muscles are dramatically higher than conventional ASOs in the transgenic human TfR1 mouse model. MAOC treatment was well tolerated in vivo and not associated with any toxicity‐related morbidity or mortality. Collectively, our data suggest that the self‐assembled MAOC is a viable option for broadening the therapeutic application of ASO via multi‐specific targeting and delivery.
Polyoxometalates‐Mediated Selectivity in Pt Single‐Atoms on Ceria for Environmental Catalysis
Authors: Lan Tianwei , Yalavarthi Rambabu , Shen Yongjie , Gao Min , Wang Fuli , Hu Qingmin , Hu Pengfei , Beladi‐Mousavi Mohsen , Chen Xin , Hu Xiaonan , Yang Huiqian , Cortés Emiliano , Zhang Dengsong 
Published: September 2024

AbstractOptimizing the reactivity and selectivity of single‐atom catalysts (SACs) remains a crucial yet challenging issue in heterogeneous catalysis. This study demonstrates selective catalysis facilitated by a polyoxometalates‐mediated electronic interaction (PMEI) in a Pt single‐atom catalyst supported on CeO2 modified with Keggin‐type phosphotungstate acid (HPW), labeled as Pt1/CeO2‐HPW. The PMEI effect originates from the unique arrangement of isolated Pt atoms and HPW clusters on the CeO2 support. Electrons are transferred from the ceria support to the electrophilic tungsten in HPW clusters, and subsequently, Pt atoms donate electrons to the now electron‐deficient ceria. This phenomenon enhances the positive charge of Pt atoms, moderating O2 activation and limiting lattice oxygen mobility compared to the conventional Pt1/CeO2 catalyst. The resulting electronic structure of Pt combined with the strong and local acidic environment of HPW on Pt1/CeO2‐HPW leads to improved efficiency and N2 selectivity in the degradation of NH3 and NO, as well as increased CO2 yield when inputting volatile organic compounds. This study sheds the light on the design of SACs with balanced reactivity and selectivity for environmental catalysis.
Highly Cytotoxic Cryptophycin Derivatives with Modification in Unit D for Conjugation
Authors: Dessin Cedric , Schachtsiek Thomas , Voss Jona , Abel Anne‐Catherine , Neumann Beate , Stammler Hans‐Georg , Prota Andrea E. , Sewald Norbert 
Published: September 2024

AbstractCytotoxic payloads for drug conjugates suitable for directed tumor therapy need to be highly potent and require a functional group for conjugation with the homing device (antibody, peptide, or small molecule). Cryptophycins are cyclodepsipeptides that stand out from the realm of natural products due to their extraordinarily high cytotoxicity. However, the installation of a suitable conjugation handle without compromising the toxicity is highly challenging. The unit D, natively 2‐hydroxyisocaproic acid (leucic acid), was envisaged as a promising attachment site based on structural information from X‐ray analysis. A versatile, scalable and efficient synthetic route towards conjugable cryptophycins with modification in unit D was developed and an array of new cryptophycin analogues was synthesized. Several derivatives, especially those containing lipophilic groups with low steric demand such as alkylated amino groups, exhibit low picomolar cytotoxicity often combined with efficacy against multidrug‐resistant tumor cells. The newly established cryptophycin analogues comprise a broad range of relevant functional groups used as conjugation handles, among them amino, hydroxy, carboxy, as well as sulfur‐containing derivatives. X‐ray crystallographic analysis of a tubulin‐bound cryptophycin together with quantitative structure activity relationship manifested rationales for the synthesis of most potent cryptophycin derivatives and further confirmed the suitability of modifications in unit D.
Efficient Water Reforming of Biomass to H2 via Well‐Organized Redox‐Neutral Cleavage of C−C, O−H and C−H Bonds
Authors: Zhang Wen‐Min , Li Yang 
Published: September 2024

AbstractHydrogen (H2) is a clean and environmentally friendly energy carrier. The depletion of fossil fuels makes renewable H2 production highly desirable. Water reforming of renewable biomass to hydrogen, with a relay of natural photosynthesis to biomass, would be an indirect pathway to realize the ideal but extremely challenging photocatalytic overall water splitting to hydrogen, with favorable thermodynamics. Since the seminal work of water reforming of biomass in 1980, great endeavors have been made. Nevertheless, hitherto, the entire kinetic pathway has been elusive, which seriously limits the reforming processes. Using a designed well‐organized redox‐neutral cleavage of C−C, O−H and C−H bonds enabled by photoelectrocatalysis, here, we show the efficient water reforming of biomass to hydrogen at room temperature, with a yield up to 93 %. The clear insights into the kinetic pathway with oxidation of carbon radicals to carbon cations as the indicated rate‐determining step, would cast brightness for efficient and sustainable hydrogen production to accelerate the hydrogen economy.
A multianalytical approach to benzodiazepine derivatives for the corrosion protection of mild steel in HCl solutions: Electrochemical analysis, SEM/EDX, XPS, DFT, and MDS calculations
Authors: Kharbouch Otmane , Dahmani Khadija , Saber Issam , El‐alouani Marouane , Errahamany Nordine , El hajri Fatima , Galai Mouhsine , Boukhris Said , Touhami Mohamed Ebn , Nassali Hakima , AlObaid Abeer A. , Al‐Maswari Basheer M. , Al‐Sadoon Mohammad K. 
Published: September 2024

AbstractThis study takes a detailed look at the corrosion inhibition capabilities of two benzodiazepine‐derived organic compounds, 3,3‐dimethyl‐11‐(4‐nitrophenyl)‐2,3,4,5,10,11‐hexahydro‐1H‐dibenzo[b,e][1,4]diazepin‐1‐one (PNO) and 3,3‐dimethyl‐11‐(2‐nitrophenyl)‐2,3,4,5,10,11‐hexahydro‐1H‐dibenzo[b,e][1,4]diazepin‐1‐one (ONO), in a 1.0‐M hydrochloric acid environment using a variety of analytical methods, including electrochemical approaches — electrochemical impedance spectroscopy (EIS) and potentio‐dynamic polarization (PDP). The results show that the concentration‐dependent inhibitory efficacy of PNO and ONO increases with increasing concentration. Both inhibitors exhibit mixed‐type behaviour, which is confirmed by the polarization results. At the optimum concentration, the inhibition efficiencies of PNO and ONO are 92.9% (PNO) and 87.6% (ONO), respectively. The effective adsorption of these inhibitors on the metal surface was also confirmed by X‐ray photoelectron spectroscopy (XPS) analysis. The existence of a barrier layer surrounding the mild steel was demonstrated using scanning electron microscopy (SEM) and energy‐dispersive X‐ray analysis (EDX), all of which were used to study the surface characterization. The most important interactions with the iron surface are achieved by inhibitors with electron‐accepting properties, according to density functional theory results and molecular dynamic simulation (MDS). With encouraging prospects for industry and metal preservation, these results pave the way for promising applications for effective corrosion protection in a 1.0‐M HCl environment.
The impact of cellulose nanocrystals on the properties of poly(2‐hydroxyethyl methacrylate)‐based contact lenses
Authors: Blanc Emilie , Faran Syed Ali , Dufresne Alain , Fitzhenry Laurence , Mariano Marcos 
Published: September 2024

AbstractContact lenses are widely used corrective devices for addressing vision impairments. In addition to their traditional role, these lenses are increasingly applied in personalized care, biosensing, and drug release, thus broadening their application as multifunctional devices. Nanoparticles are often used to introduce new functionalities to these materials. In this context, the role played by different nanoparticles requires attention to ensure that lens manufacture and patient comfort meet the desired criteria. This study investigates the properties of contact lenses prepared by incorporating cellulose nanocrystals into the poly(2‐hydroxyethyl methacrylate) matrix. Using photopolymerization reactions, polyHEMA‐based lenses and nanocomposites containing freeze‐dried and never‐dried nanoparticles were obtained. Fundamental properties of these lenses were evaluated to verify whether the nanoparticles could have a negative effect on the materials. Subsequently, the potential impact of these nanoparticles on the adsorption of model amino acids was investigated. Our findings reveal that the presence of cellulose nanocrystals modifies on lens thickness, light transmittance, mechanical properties, refractive index (RI), and the uptake of amino acids by the contact lenses. This could potentially affect patient comfort and modify the uptake and release of pharmaceutical ingredients by the material. Additionally, it could impact how these materials interact with biomolecules present in the lacrimal fluid.
Integrating Direct Experimental Fishing and Environmental DNA Metabarcoding to Assess Fish Biodiversity in the Cibareno River, Indonesia, to Support Fishway Design
Authors: Kurniawan Kurniawan , Wibowo Arif , Prakoso Vitas Atmadi , Rochman Fathur , Irawan Deni , Atminarso Dwi , Prasetyo Andhika Prima , Deniansen Tri , Ginanjar Rendy , Zamroni Mochammad , Iswantari Aliati , Andriyono Sapto , Surbani Indah Lestari , Rosadi Imron , Jaya Yohanes Yudha P. , Sudarsono Sudarsono , Nagai Satoshi , Rourke Meaghan , Hubert Nicolas , Stuart Ivor , Baumgartner Lee 
Published: September 2024

ABSTRACT

A fishway is an engineered structure designed to help fish navigate past artificial barriers in rivers such as dams, weirs and regulators. An effective fishway design requires an understanding of fish biodiversity and migration requirements of the local community.

To support the conceptual design of a fishway at Caringin Weir in the Cibareno River in Indonesia, we conducted a fish biodiversity assessment using experimental fishing and an eDNA metabarcoding survey.

In early 2022, experimental fishing was conducted at six sampling sites upstream and downstream of the planned weir, and the sites were surveyed seven times during the wet and dry seasons. Environmental DNA sampling was conducted once during the wet season at each of the six sites.

A total of 72 aquatic species were detected, comprising 40 fish species and seven crustacean species captured during experimental fishing and 36 fish species identified through eDNA metabarcoding. Twelve fish species (18.46%) were detected using both methods. The total number of all species caught and species richness in experimental fishing varied significantly between upstream and downstream areas (p < 0.05), but there were no significant differences between seasons (p > 0.05). There was also a significant difference in the species richness upstream and downstream using eDNA metabarcoding (p < 0.05). There were also numerous diadromous species, further highlighting the need for an effective fishway design to enable these species to complete their migrations.

Based on the species present, migratory behaviour and economic importance, we prioritised six fish and crustacean species to be considered during fishway design: Anguilla marmorata, Tor tambra, Barbodes binotatus, Sicyopterus sp., Rhyacichthys aspro and Macrobrachium sp.
The effects of organic acids on broiler chicken nutrition: A review
Authors: Chukwudi Prosper , Umeugokwe Paulinus Ikenna , Ikeh Nnanna Ephraim , Amaefule Bright Chigozie 
Published: September 2024

AbstractTo meet the requirements of the modern chicken industry, high levels of productivity and efficient feed conversion are necessary. This can be partially accomplished by using particular feed additives. The prohibition of antibiotic usage has compelled researchers to explore alternative options to antibiotics. Organic acids and their salts are commonly employed in poultry farming as substitutes for antibiotic growth promoters. These compounds are distinguished by the presence of a carboxylic acid group and are classified as weak acids. They function as intermediates in the degradation of amino acids, sugars, and fatty acids. Organic acids encompass a wide range of chemical substances that are commonly found naturally as fundamental constituents of animal tissues, plants, and microorganisms. Organic acids decrease the pH of the intestinal tract, promoting the growth of beneficial microorganisms. This enhances the digestion of nutrients and increases immunity in chickens, eliminating the need for antibiotics. This review provides an overview of recent research findings regarding the antimicrobial effect of organic acids and the impact of organic acids on growth performance, intestinal health, and carcass and organ characteristics of broiler chickens.
Inorganic‐Organic Composite Cathode Materials for Aqueous Zinc Ion Batteries
Authors: Zhang Weidong , Lv Yaokang , Xiong Wei , Gan Lihua , Liu Mingxian 
Published: September 2024

AbstractAs potential candidates for large‐scale energy storage systems, aqueous zinc‐ion batteries (AZIBs) have attracted more and more attention from researchers and investors. Tremendous efforts have been devoted to develop high‐efficient cathode materials for improving comprehensive performances of AZIBs. Recently reported inorganic‐organic composite (IOC) cathode materials exhibited excellent electrochemical performance and were generally superior to corresponding inorganic or organic cathode materials. This paper presents a timely review on recent progresses and challenges in IOCs for AZIBs. Preparation strategies of IOCs have been elaborated and categorized, recent advances and main working mechanisms of IOCs are exhibited with a focus on the analysis methods for mechanism studies, outlooks and challenges of IOC cathodes for AZIBs are outlined to guide their future development.
A limited sampling model to estimate the area under the curve of mycophenolic acid in hematopoietic stem cell transplantation recipients
Authors: Lin Liangmo , Hong Mianhui , Fu Xiangjun 
Published: September 2024

AbstractRelationship between the areas under the curve (AUC) of mycophenolic acid (MPA) and the likelihood of rejection is well‐established in solid organ transplantation recipients. In hematopoietic stem cell transplantation (HSCT), MPA AUC is also linked to graft versus host disease. This study aimed to develop a simplified method to estimate MPA AUC0–12 in Chinese patients undergoing allogeneic HSCT (allo‐HSCT). Intensive sampling was conducted in 22 patients who were orally administered mycophenolate mofetil. Plasma concentrations of total MPA were measured, and a model predicting AUC0–12 using data from these 22 patients was constructed through regression analysis. The accuracy of the most suitable model was assessed in an additional 20 patients. None of the individual MPA concentrations showed a strong correlation with AUC0–12 (r2 < 0.7). Models utilizing 4 or more concentrations were found to effectively estimate MPA AUC0–12 (r2 > 0.87). The most operationally feasible model demonstrated good predictive performance with a mean absolute percentage error (APE%) < 20%. Single MPA concentrations showed poor correlation with MPA AUC0–12. A model utilizing 4 oral concentrations (0, 0.5, 1, and 4 h postdose) over a 12‐h period could effectively estimate MPA AUC0–12 with precise results and minimal bias.
Nanosensor based on HP‐MAP1 and carbon nanotubes for bacteria detection
Authors: Silva Winne F. S. M. , Migliolo Ludovico , Silva Patrícia S. , Lima Glaucia M. S. , Oliveira Maria D. L. , Andrade Cesar A. S. 
Published: September 2024

AbstractHealthcare‐associated infections (HAIs) pose significant challenges to global health due to pathogen complexity and antimicrobial resistance. Biosensors utilizing antimicrobial peptides offer innovative solutions. Hylarana picturata Multiple Active Peptide 1 (Hp‐MAP1), derived from Temporin‐PTA, exhibits antibacterial properties sourced from the skin secretions of the Malaysian fire‐bellied frog. An innovative sensing layer was developed for the electrochemical biorecognition of diverse pathogens: Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus. Electrochemical impedance spectroscopy differentiated microorganisms based on distinct electrochemical responses. The sensor layer, composed of functionalized multi‐walled carbon nanotubes (MWCNTs) associated with Hp‐MAP1, exhibited varying levels of charge transfer resistance (RCT) for different microorganisms. Gram‐negative species, especially P. aeruginosa, displayed higher RCT values, indicating better impedimetric responses. Excellent LODs were observed for P. aeruginosa (0.60), K. pneumoniae (0.42), E. coli (0.67), and S. aureus (0.59), highlighting the efficacy of the MWCNTs/Hp‐MAP1 biosensor in microbial identification. The MWCNTs/Hp‐MAP1 biosensor platform presents a promising and effective microbial identification strategy with potential healthcare applications to mitigate HAIs and enhance patient care.