bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presidential Address 2015—Negotiating Sites of Memory
Authors: Ferguson Margaret 
Published: November 2015

This text was written as a talk for a particular occasion, the Presidential Address on 9 January 2015 during the MLA Annual Convention in Vancouver, British Columbia. I have not removed the traces of this occasion from the text because they are integral to its argument about sites of memory. I hope my readers will imagine themselves as auditors gathered in a large room in the West Building of the Vancouver Convention Centre, built on the edge of a waterway called Burrard Inlet (fig. 1). That waterway, which is represented in several of the images that accompany this text, had—and still has—a different name in the languages of the indigenous peoples who have inhabited the Vancouver area since before it became part of an American hemisphere. Names, in languages that are ancient but also modern, are a key topic in the reflections that follow.I'm grateful to you for the gift of your time. Though my talk explores a view of historical time as a multidirectional and multidimensional phenomenon, I'm aware that our shared time in this room goes in one direction in the simple sense that we'll all be older when this session ends, and probably even more hungry, thirsty, and tired than we are now. I've found that the MLA convention sometimes feels like a memory marathon, with special testings of the brain muscles that allow us to recognize faces and recall the first and last names of acquaintances, and even of good friends, whom we haven't seen for a while. Such experiences of remembering and forgetting contributed to my decision to focus on the MLA itself as one of the two sites of memory I want to explore with you this evening. The other site I want to think about is Vancouver, the place where we are now: a modern city built on a site where humans have been living for the last eight to ten millennia (Carlson 12-16).
S0502: A SWOG Phase III Randomized Study of Imatinib, With or Without Bevacizumab, in Patients With Untreated Metastatic or Unresectable Gastrointestinal Stromal Tumors
Authors: Blanke Charles D. , Rankin Cathy , Corless Christopher , Eary Janet F. , Mulder Karen , Okuno Scott H. , George Suzanne , Heinrich Michael 
Published: November 2015

Abstract

Lessons Learned
Despite having significant rationale, S0502 failed to accrue for a number of reasons. Vetting a trial first, with scientific experts and funding agencies, does not guarantee success, especially when dealing with a rare tumor and/or one with an existing highly effective therapy. In the present case, adding an intravenous drug to an oral medication as part of a regimen expected to be continued for many years likely decreased patient (and physician) convenience and, thus, interest in the study.

Background.
Imatinib mesylate, a potent inhibitor of the KIT and PDGFR tyrosine kinases, is highly effective in the treatment of advanced gastrointestinal stromal tumors (GISTs). However, most imatinib-treated tumors eventually become resistant, accounting for a median progression-free survival of 19–23 months. Expression of vascular endothelial growth factor (VEGF) correlates with poor prognosis in GIST; bevacizumab, a monoclonal antibody against VEGF, is effective in a variety of solid tumors. We postulated combination therapy with imatinib plus bevacizumab would benefit patients with advanced GIST, particularly those reliant on VEGFA-dependent angiogenesis.

Methods.
Patients with metastatic or surgically unresectable GIST were eligible for this phase III open-label clinical trial, S0502. At registration, patients were randomly assigned to either imatinib 400 mg (standard) or 800 mg (patients with exon 9 KIT mutations), or imatinib plus bevacizumab, 7.5 mg/kg i.v. every 3 weeks. Patients were treated to progression, symptomatic deterioration, unacceptable toxicity, treatment delay greater than 4 weeks, or patient choice to withdraw from the study. The primary objective was to determine whether the addition of bevacizumab to imatinib would improve progression-free survival (PFS) in first-line treatment of incurable GIST.

Results.
S0502 opened on April 15, 2008. As of fall 2009, only 12 patients from at least 178 eligible SWOG centers plus those participating through Cancer Trials Support Unit had been entered in the study. Despite an aggressive promotion scheme involving the other cooperative groups and a major GIST patient advocacy group, accrual remained slow. The trial was closed on October 1, 2009, having accrued only 2% of the 572 patients planned. No scientific conclusions were forthcoming because of the small number of patients entered in the study. Two patients of the 6 in the combination arm reported grade 3 toxicities, 1 with proteinuria and 1 with fatigue, upper gastrointestinal hemorrhage, and anemia.

Conclusion.
No conclusions may be drawn from this trial and, thus, the combination of imatinib plus bevacizumab cannot be recommended for use.
Views of students’, teachers’ and parents’ on the tablet computer usage in education
Authors: Soykan Emrah 
Published: November 2015

This study aims at identification of views of teachers, students and their parents at Near East College in North Cyprus on use of tablets in education. The research is a descriptive case study. In collection of data, semi-structured interviews appropriate for qualitative research methods are used. Study group for this research is composed of high educated teachers (f=64), students (f=319) and also parents (f=134). As result of the analysis carried out in this research which was performed in this direction, it has been seen that teachers, students and parents evaluate the problems related with tablet PCs under the following two sub-dimensions; the experienced problems of during tablet supported education and the benefits of tablet pc usage in education. If we look at the results in this line, we come across with connectivity and technical infrastructure problems which interrupts the lesson or even causes it to end as the biggest problem experienced by teachers and students during the learning activities. The biggest concern of parents, another of our study groups, regarding the use of tablets in education is that games may decrease students’ motivation. Teachers stated the biggest benefit provided by tablet supported education is the increase in learning speed of students as a result of visuals and interaction provided by tablets.Keywords: mobile learning, tablet pcs, tablet pc supported instruction, technology based instruction, information technology.
Analyzing the levels of depressive symptoms among secondary school students in Canada and Turkey
Authors: Karatas Zeynep , Tremblay Richard Ernest 
Published: November 2015

<p>To examine the level of depressive symptoms of the secondary school students in Turkey and Canada has been aimed in this study. The research group of the study consists of 1050 secondary school students with the average age of 13. Their socio-economic levels are low in both countries, Canada and Turkey. Data has been analyzed by independent groups t-Test, Two Way ANOVA and Tukey HSD Test. The study revealed that the level of depressive symptoms of Turkish secondary school students has been found higher than the level of depressive symptoms of Canadian secondary school students. While the levels of depressive symptoms of the Canadian female students have been higher than male students, the level of depressive symptoms of Turkish students has not differentiated in terms of their genders. While the common interactions of the educational levels of Turkish students’ parents on depressive symptoms have been found significant, the levels of depressive symptoms of Canadian pupils have not presented any changes according to parents’ educational levels. The results of the study have been discussed and some suggestions have been presented.</p><p> Keywords: depressive symptoms, secondary school students, early adolescent, Canada, Turkey</p>
Social anxiety experiences and responses of university students
Authors: Akacan Behiye , Secim Gurcan 
Published: November 2015

The aim of this study is to examine the responses of university students in social anxiety situations in order to create a psychological counselling program with a structured group based on Cognitive Behavioural and Existential Approaches. These responses involve the behaviour and thoughts of the university students in situations where they experience or anticipate social anxiety. The semi-structured interview form developed by the researchers was used in the study during the face-to-face interviews with fifty-one 4th year students from the Guidance and Psychological Counselling (GPC) and Pre-School Teaching (PST) departments. The scope of the interview form includes the situations where 1) students experience social anxiety in the school setting and their thoughts and behaviours regarding these situations, 2) the situations where they anticipate social anxiety in their future profession, and 3) the situations where they experience social anxiety in their daily lives. Our aim was to collect data from these areas. The data collected were analysed through content analysis. The findings of the study revealed that the thoughts regarding the social anxiety situations of the final year students studying in Guidance and Psychological Counselling and Pre-School Teaching departments are generally negative and their behaviour usually presents as desertion or avoidance.Keywords: university students, social anxiety, group counselling.
Class teachers’ expectations from teacher candidates from three points of views
Authors: Tacman Muge , Comunoglu Nazan 
Published: November 2015

The general aim of this study is to find out the way how the primary school class teachers evaluate the candidates, what their expect from the candidates and the effectivenes of the teaching training program being conducted in Ataturk Teacher Training Academy (AOA) to fulfill these expectations. The study is carried out by phenomenology, a qualitative method. Descriptive and content analysis were used in order to analyze the data. Study group is composed of three different dimensions. In the first dimension, a total of 52 teachers (2 school masters and 50 teachers), who had teaching practice students in their classes in last three years, had served during 2013-2014 and served in 5 different state primary schools that are in collaboration with AOA in the context of Teaching Practice Lessons. In order to analyze the data obtained from the views of these teachers, 15 teachers of AOA and 15 teachers that have graduated from AOA in 2012-2013/ 2013-2014 academic season form the second and third study groups respectively. Research findings were studied and interpreted in the framework of 4 main topics which are field knowledge, basic professional attitudes, effective communication and teaching abilities. Keywords: teacher training, candidate teacher, class teacher, primary school, North Cyprus.
Randomized Clinical Trial Comparing Basal Insulin Peglispro and Insulin Glargine in Patients With Type 2 Diabetes Previously Treated With Basal Insulin: IMAGINE 5
Authors: Buse John B. , Rodbard Helena W. , Trescoli Serrano Carlos , Luo Junxiang , Ivanyi Tibor , Bue-Valleskey Juliana , Hartman Mark L. , Carey Michelle A. , Chang Annette M. 
Published: November 2015

OBJECTIVE
To evaluate the efficacy and safety of basal insulin peglispro (BIL) versus insulin glargine in patients with type 2 diabetes (hemoglobin A1c [HbA1c] ≤9% [75 mmol/mol]) treated with basal insulin alone or with three or fewer oral antihyperglycemic medications.

RESEARCH DESIGN AND METHODS
This 52-week, open-label, treat-to-target study randomized patients (mean HbA1c 7.42% [57.6 mmol/mol]) to BIL (n = 307) or glargine (n = 159). The primary end point was change from baseline HbA1c to 26 weeks (0.4% [4.4 mmol/mol] noninferiority margin).

RESULTS
At 26 weeks, reduction in HbA1c was superior with BIL versus glargine (−0.82% [−8.9 mmol/mol] vs. −0.29% [−3.2 mmol/mol]; least squares mean difference −0.52%, 95% CI −0.67 to −0.38 [−5.7 mmol/mol, 95% CI −7.3 to −4.2; P &lt; 0.001); greater reduction in HbA1c with BIL was maintained at 52 weeks. More BIL patients achieved HbA1c &lt;7% (53 mmol/mol) at weeks 26 and 52 (P &lt; 0.001). With BIL versus glargine, nocturnal hypoglycemia rate was 60% lower, more patients achieved HbA1c &lt;7% (53 mmol/mol) without nocturnal hypoglycemia at 26 and 52 weeks (P &lt; 0.001), and total hypoglycemia rates were lower at 52 weeks (P = 0.03). At weeks 26 and 52, glucose variability was lower (P &lt; 0.01), basal insulin dose was higher (P &lt; 0.001), and triglycerides and aminotransferases were higher with BIL versus glargine (P &lt; 0.05). Liver fat content (LFC), assessed in a subset of patients (n = 162), increased from baseline with BIL versus glargine (P &lt; 0.001), with stable levels between 26 and 52 weeks.

CONCLUSIONS
BIL provided superior glycemic control versus glargine, with reduced nocturnal and total hypoglycemia, lower glucose variability, and increased triglycerides, aminotransferases, and LFC.
Rhythms of Global Urbanisation
Authors: Mbo Emil Abossolo , Kilian Cassis 
Published: November 2015

Since global interdependencies are a feature of urbanisation, Kwame Anthony Appiah's pleading for an education in 'cosmopolitan citizenship' is forward-looking. Given increasing mobility, handling different urban rhythms is as important as dealing with different languages. Actors explore how airports, supermarkets and cemeteries react to gait, respiration and heartbeat and how people adopt or impose rhythms. Such investigations might appear superficial from an academic perspective, but they bear resemblance to ethnographic fieldwork.We (an actor and an anthropologist) refer to the shift from participant observation to collaboration proposed by George Marcus, and conjointly explore rhythmic aspects of urbanisation, which are difficult for scholars to grasp. Our aim is to expand anthropological concepts, methods and forms of representation. In reference to Paul Stoller, we consider acting methods a 'sensuous scholarship' and argue that rhythm allows us to explore preverbal aspects of feelings of belonging or alienation in the urban space.
Découverte de nouveaux documents relatifs au Polyptyque de Saint-Remi de Reims. A propos d'une édition récente
Authors: Desportes Pierre , Dolbeau François , Devroey Jean-Pierre 
Published: November 2015

L'édition de Jean-Pierre Devrœy, publiée en 1984 dans le 163e volume des Travaux de l'Académie Nationale de Reims, a attiré l'attention sur le Polyptyque de Saint-Remi. Cet article a pour objet de présenter deux nouvelles copies, complètes et indépendantes, de ce document, retrouvées l'une à Carpentras dans les papiers de Peiresc, l'autre à Oxford dans ceux d'un correspondant de Peiresc, l'érudit anglais Henry Spelman.
Elles permettent d'affirmer que le manuscrit rémois à l'origine de toutes les copies du Polyptyque avait été transcrit dans le second tiers du IXe siècle. Elles fournissent un bref appendice inédit et donnent la possibilité d'asseoir sur une base solide la chronologie des divers éléments constitutifs d'un texte dont le caractère composite fait l'exceptionnelle richesse.
La religion populaire dans les Pays-Bas méridionaux au XVIIIe siècle
Authors: Cloet Michel 
Published: November 2015

Until about 1770, XVIIIth century popular religion assumes the same features as in the previous century : a practice all but universal (mass and sacraments) and a massive attendance to devotions (processions, cult of the Saints and above all of the Virgin, success of places of pilgrimage, confraternities). The number of diocesan priests was high, particularly in the third quarter of the XVIIIth century. Déchristianisation can thus certainly not be assigned to a lack of priests.
The realization that religious life keeps its full vigour longer than hitherto believed is an original and new discovery of this article. The study of religious life in the major cities remains yet to be done.
Boosting in Nonlinear Regression Models with an Application to DCE-MRI Data
Authors: Feilke M. , Bischl B. , Gertheiss J. , Schmid V. J. 
Published: November 2015

SummaryBackground: For the statistical analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data, compartment models are a commonly used tool. By these models, the observed uptake of contrast agent in some tissue over time is linked to physiologic properties like capillary permeability and blood flow. Up to now, models of different complexity have been used, and it is still unclear which model should be used in which situation. In previous studies, it has been found that for DCE-MRI data, the number of compartments differs for different types of tissue, and that in cancerous tissue, it might actually differ over a region of voxels of one DCE-MR image. Objectives: To find the appropriate number of compartments and estimate the parameters of a regression model for each voxel in an DCE-MR image. With that, tumors in an DCE-MR image can be located, and for example therapy success can be assessed. Methods: The observed uptake of contrast agent in a voxel of an image of some tissue is described by a concentration time curve. This curve can be modeled using a nonlinear regression model. We present a boosting approach with nonlinear regression as base procedure, which allows us to estimate the number of compartments and the related parameters for each voxel of an DCE-MR image. In addition, a spatially regularized version of this approach is proposed. Results: With the proposed approach, the number of compartments – and with that the complexity of the model – per voxel is not fixed but data-driven, which allows us to fit models of adequate complexity to the concentration time curves of all voxels. The parameters of the model remain nevertheless interpretable because of the underlying compartment model. Conclusions: The proposed boosting approaches outperform all competing methods considered in this paper regarding the correct localization of tumors in DCE-MR images as well as the spatial homogeneity of the estimated number of compartments across the image, and the definition of the tumor edge.
Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry
Authors: Demirkaya Erkan , Saglam Celal , Turker Turker , Koné-Paut Isabelle , Woo Pat , Doglio Matteo , Amaryan Gayane , Frenkel Joost , Uziel Yosef , Insalaco Antonella , Cantarini Luca , Hofer Michael , Boiu Sorina , Duzova Ali , Modesto Consuelo , Bryant Annette , Rigante Donato , Papadopoulou-Alataki Efimia , Guillaume-Czitrom Severine , Kuemmerle-Deschner Jasmine , Neven Bénédicte , Lachmann Helen , Martini Alberto , Ruperto Nicolino , Gattorno Marco , Ozen Seza ,   for The Paediatric Rheumatology International Trials Organisations (PRINTO) and Eurofever Project
Published: November 2015

Objective.Our aims were to validate the pediatric diagnostic criteria in a large international registry and to compare them with the performance of previous criteria for the diagnosis of familial Mediterranean fever (FMF).Methods.Pediatric patients with FMF from the Eurofever registry were used for the validation of the existing criteria. The other periodic fevers served as controls: mevalonate kinase deficiency (MKD), tumor necrosis factor receptor–associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS), aphthous stomatitis, pharyngitis, adenitis syndrome (PFAPA), and undefined periodic fever from the same registry. The performances of Tel Hashomer, Livneh, and the Yalcinkaya-Ozen criteria were assessed.Results.The FMF group included 339 patients. The control group consisted of 377 patients (53 TRAPS, 45 MKD, 32 CAPS, 160 PFAPA, 87 undefined periodic fevers). Patients with FMF were correctly diagnosed using the Yalcinkaya-Ozen criteria with a sensitivity rate of 87.4% and a specificity rate of 40.7%. On the other hand, Tel Hashomer and Livneh criteria displayed a sensitivity of 45.0 and 77.3%, respectively. Both of the latter criteria displayed a better specificity than the Yalcinkaya-Ozen criteria: 97.2 and 41.1% for the Tel Hashomer and Livneh criteria, respectively. The overall accuracy for the Yalcinkaya-Ozen criteria was 65 and 69.6% (using 2 and 3 criteria), respectively. Ethnicity and residence had no effect on the performance of the Yalcinkaya-Ozen criteria.Conclusion.The Yalcinkaya-Ozen criteria yielded a better sensitivity than the other criteria in this international cohort of patients and thus can be used as a tool for FMF diagnosis in pediatric patients from either the European or eastern Mediterranean region. However, the specificity was lower than the previously suggested adult criteria.
A Multicenter Study of Invasive Fungal Infections in Patients with Childhood-onset Systemic Lupus Erythematosus
Authors: Silva Marco F. , Ferriani Mariana P. , Terreri Maria T. , Pereira Rosa M. , Magalhães Claudia S. , Bonfá Eloisa , Campos Lucia M. , Okuda Eunice M. , Appenzeller Simone , Ferriani Virgínia P. , Barbosa Cássia M. , Ramos Valéria C. , Lotufo Simone , Silva Clovis A. 
Published: November 2015

Objective.To study the prevalence, risk factors, and mortality of invasive fungal infections (IFI) in patients with childhood-onset systemic lupus erythematosus (cSLE).Methods.A retrospective multicenter cohort study was performed in 852 patients with cSLE from 10 pediatric rheumatology services. An investigator meeting was held and all participants received database training. IFI were diagnosed according to the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group Consensus Group criteria (proven, probable, and possible). Also evaluated were demographic, clinical, and laboratory data, and disease activity [SLE Disease Activity Index 2000 (SLEDAI-2K)], cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index), treatment, and outcomes.Results.IFI were observed in 33/852 patients (3.9%) with cSLE. Proven IFI was diagnosed in 22 patients with cSLE, probable IFI in 5, and possible IFI in 6. Types of IFI were candidiasis (20), aspergillosis (9), cryptococcosis (2), and 1 each disseminated histoplasmosis and paracoccidioidomycosis. The median of disease duration was lower (1.0 vs 4.7 yrs, p < 0.0001) with a higher current SLEDAI-2K [19.5 (0–44) vs 2 (0–45), p < 0.0001] and current prednisone (PRED) dose [50 (10–60) vs 10 (2–90) mg/day, p < 0.0001] in patients with IFI compared with those without IFI. The frequency of death was higher in the former group (51% vs 6%, p < 0.0001). Logistic regression analysis revealed that SLEDAI-2K (OR 1.108, 95% CI 1.057–1.163, p < 0.0001), current PRED dose (OR 1.046, 95% CI 1.021–1.071, p < 0.0001), and disease duration (OR 0.984, 95% CI 0.969–0.998, p = 0.030) were independent risk factors for IFI (R2 Nagelkerke 0.425).Conclusion.To our knowledge, this is the first study to characterize IFI in patients with cSLE. We identified that disease activity and current glucocorticoid use were the main risk factors for these life-threatening infections, mainly in the first years of disease course, with a high rate of fatal outcome.