bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized analysis of foveal avascular zone with optical coherence tomography angiography
Authors: Burnasheva Maria A. , Kulikov Alexey N. , Maltsev Dmitrii S. 
Published: January 2018

Aim. To investigate the relationship between the foveal avascular zone (FAZ) and inner nuclear layer (INL) free zone in order to provide a personalized approach for evaluation of the FAZ area with optical coherence tomography-angiography (OCTA).
Material and methods.Thirty-six healthy individuals (36 eyes) and 9 patients (12 eyes) with nonproliferative diabetic retinopathy (nPDR) were included in this study. The FAZ area as well as INL-free zone were measured in superficial capillary plexus on OCTA images. The FAZ area, INL-free area, and the ratio of the INL-free area to the FAZ area were compared between healthy subjects and nPDR patients.
Results. The mean FAZ area in healthy subjects and nPDR patients was 0.33 0.1 and 0.56 0.28 mm2 (p 0.05), respectively. The mean INL-free zone in healthy subjects and nPDR patients was 0.33 0.07 and 0.28 0.1 mm2 (p 0.05), respectively. The ratio of the INL-free area to the FAZ area in healthy subjects and nPDR patients was 1.08 0.25 and 0.57 0.2 (p 0.001), respectively. Receiver operating characteristic analysis showed that the ratio of the INL-free area to the FAZ area had the higher area under curve (0.98; 91.7% sensitivity and 97.2% specificity) compared to the FAZ area (0.8; 66.7% sensitivity and 87.1% specificity) for differentiating nPDR from healthy eyes.
Conclusion. This study showed that personalized analysis of the FAZ area based on the relationship between the actual FAZ and INL-free zone has better diagnostic accuracy compared to the conventional FAZ area measurement on OCTA images.
Effect of honey on nocturnal cough among children in Taif city
Authors: Al-Juaid Hanan , AlJuaid Aljwharah , Abuharba Walaa , Abouhamda Ayman 
Published: January 2018

Background: Nocturnal cough is a common disturbing symptom that affects children during upper respiratory tract infections and can have a major negative impact on child and parents’ sleep quality. Many pharmaceutical medications, herbal regimens, and non-pharmaceutical advice are prescribed to reduce nocturnal cough. The aim of this research was to study the impact of honey on nocturnal cough in children.Methods: A descriptive study was conducted on 226 children in Taif city, KSA using a pre-prepared questionnaire to assess the cough severity and response to honey in comparison to other treatment modalities. Data collected were then analyzed using SPSS software.Results: The study was conducted on 226 children (51.77% were females). Children who used honey were significantly older (mean age 7.64±3.8 years) than those who used medications (mean age 6.98±60) (p=0.025). Children who used honey had a higher prevalence of headache (p=0.001) and malaise (p<0.001) than children who did not receive honey. The use of honey was also significantly associated with high cough severity scores. The use of honey seemed to significantly reduce both the cough severity score and combined severity scores, with odd’s ratios of 0.46 and 0.19, respectively (p=0.020 and <0.001). However, it was associated with fewer satisfaction rates and fewer intentions to re-use in next attacks (p=0.025).Conclusions: Honey has a beneficial effect on treating nocturnal cough in children. It decreases the severity of cough as well as the frequency of cough. It is commonly used among older Saudi children who have cough associated with malaise and fever. However, it is not satisfactory for patient and parental relief in Taif city because it doesn’t improve the sleep quality of patients or parents.
THE REFLECTION OF TRANSITIONAL SOCIETY OF MYTILENE AT THE END OF THE ARCHAIC PERIOD (8TH – 5TH CENTURY B.C.) A STUDY ON SAPPHO’S “ODE TO ANAKTORIA”
Authors: Kokkaliari Lydia Kanelli Kyvelou , Sudardi Bani 
Published: January 2018

This article discusses Sappho’s “Ode to Anaktoria” (fragment 16) poem as a ‘marginal’ product of an aristocratic intellectual in the transitional society of Mytilene at the end of the Archaic Period (8th-5th century B.C.). The research method is a kind of media analysis. The mean of “media” in this paper related to “A means by which something is communicated or expressed” It is laso relate to the intervening substance through which sensory impressions are conveyed or physical forces are transmitted. Media also means as a substance in which an organism lives or is cultured. On the other hand, media is a material or form used by an artist, composer, or writer; We interpreted Ode to Anaktoria in the means as the terms of media above. Sappho (born 610, died 570 B.C.) is a renowned Greek lyric poetess and musician and is greatly admired in all ages for the beauty of her writing style. Plato’s 16th epigram dedicated to her reads “Some say there are nine Muses; but they should stop to think. Look at Sappho of Lesbos; she makes a tenth”. Sappho is additionally ranked among the Nine Lyric Poets esteemed by the scholars of Hellenistic Alexandria as worthy of critical study. “Ode to Anaktoria” is read through the historic-political concept of hegemony as suggested by Gramsci. In this view, the moment of “hegemony” or of cultural leadership is systematically upgraded precisely in opposition to the mechanistic and fatalistic concepts of economism. Sappho’s fragment 16 does not only indicate defiance to androcentric (epic) categories; she suggests nonnormative, thus new, ways of contemplating life (lyric).
Synthesis of Vanadium (III) Doped Anatase TiO2 by Solid State Reaction Method
Authors: Aini Nur , Ningsih Rachamawati 
Published: January 2018

Anatase of Titanium dioxide (TiO<sub>2</sub>) was doped with vanadium ions (V<sup>3+</sup>), at doping levels ranging from 0.3, 0.5 to 0.7 atomic percentage in order to increase its photocatalytic activity under visible light irradiation. Vanadium doped TiO<sub>2</sub> was synthesized by solid state reaction method. Its physicochemical properties characterized by powder X-ray diffraction (XRD) and UV-Vis diffuse reflectance spectroscopy (DRS). Doping with V(III) resulted in a single phase structure of anatase TiO<sub>2</sub> with nanosize crystal ranging from 53.06 to 59.59 nm. Vanadium doping also resulted in a red-shift of the photophysical response of TiO<sub>2</sub> that was reflected in an extended absorption in the visible light between 400 and 700 nm.
Pengembangan dan Validasi Metode Spektroskopi Serapan Atom (SSA) untuk Penentuan Logam Berat Kadmium (Cd) dan Timbal (Pb) dalam Produk Cokelat
Authors: Taufiq Moh. , Sabarudin Akhmad , Mulyasuryani Ani 
Published: January 2018

<p align="center"><strong>ABSTRAK</strong></p><p>Pengembangan dan validasi metode analisis telah dilakukan untuk penentuan logam berat Cd dan Pb dalam 2 (dua) jenis sampel cokelat. Sampel ditambahkan HNO<sub>3</sub> 65 % dan didestruksi dengan gelombang mikro rumahan <em>(domestic microwave)</em> selama 2 menit, kemudian dianalisis menggunakan spektroskopi serapan atom (SSA). Hasil analisis menunjukkan bahwa destruksi gelombang mikro telah memenuhi persayaratan validasi seperti linieritas lebih besar dari 0,99, kisaran perolehan kembali 93,8-103,2 %, standar deviasi relatif (RSD) &lt; 5 %, konsentrasi Cd dan Pb lebih besar dari batas deteksi metode (LOD) dan batas kuantitasi (LOQ), dan memiliki kekuatan metode <em>(robustness)</em> cukup baik untuk penentuan logam Cd dan Pb dalam cokelat. Uji t indenpenden (sig 5%) menunjukkan standar deviasi relatif (RSD) dan perolehan kembali (akurasi) logam Cd dan Pb menggunakan metode destruksi basah sistem gelombang mikro dan destruksi kering (standar SNI 7934:2014) relatif sama atau tidak berbeda secara signifikan. Prosedur destruksi gelombang mikro sangat praktis, dan dikategorik sebagai metode preparasi yang mudah, cepat, akurat, dapat diandalkan dan dapat dijadikan sebagai metode analisis rutin di dalam laboratorium dengan beberapa jenis sampel dalam jumlah yang banyak.</p>
Optimization of Silylation for Parabens Determination by Gas Chromatography-Mass Spectrometry
Authors: Djatmika Rosalina , Ding Wang-Hsien 
Published: January 2018

A low cost, environmental friendly and convenient method for parabens derivatization using Gas Chromatography-Mass Spectrometry (GC-MS) analysis is investigated. Derivatization is needed to enhance the thermal stability, detectability, and volatility of parabens to make them amenable for gas chromatographic analysis. This method involved on-line derivatization by silylating reagent: N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide (MTBSTFA), N,O-bis (trimethylsilyl) trifluoroacetamide (BSTFA), N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA), and N,O-bis(trimethylsilyl)acetamide (BSA). The variables affected the derivatization process, such as, types and volumes of silylating reagents, injection port temperature, and purge-off time, were evaluated to obtain the optimal condition for determination of parabens. The Relative Response Factors (RRF) was used as a parameter of parabens derivatization efficiency to obtain the best compromise condition of each variable. On a comprehensive level, a comparison of the optimal condition of each silylating reagent was evaluated. Moreover, 1 µL of MSTFA at 260°C of injection port temperature and 2.5 min purge-off time (in splitless mode) obtained the most effective of derivatization process.
ANALISIS HKSA SENYAWA ANTIDIABETIK TURUNAN TRIAZOLOPIPERAZIN AMIDA MENGGUNAKAN METODE SEMIEMPIRIK PM3
Authors: Asmara Anjar Purba , Mudasir Mudasir , SIswanta Dwi 
Published: January 2018

<p>Analisis hubungan kuantitatif struktur dan aktivitas (HKSA) dilakukan untuk senyawa turunan triazolopiperazin amida untuk menghibisi enzim DPP IV penyebab diabetes melitus tipe 2. Analisis ini dilakukan dengan pemodelan molekul turunan triazolopiperazin amida dan perhitungan deskriptor HKSA menggunakan metode semiempirik PM3 dengan program Hyperchem<sup>Ò</sup>. Analisis data menggunakan metode analisis regresi multilinear untuk parameter elektronik dan molekular dengan program SPSS<sup>Ò</sup>. Persamaan terbaik yang diperoleh adalah:</p><p>-log IC<sub>50 </sub>= 79,955 - (11,635*qC1) - (2,094*qC2) - (34,6*qN11) + (797,684*qC15) + (0,288*m)</p><p class="BodyAbstract"> n = 18; r = 0,714; adjusted r<sup>2</sup> = 0,305; F<sub>hit</sub><sup>/</sup>F<sub>tab</sub> = 1,239; PRESS = 0,017.</p><p class="BodyAbstract">Berdasarkan persamaan tersebut, senyawa dengan aktivitas terbaik yang diusulkan adalah:</p><p><em>(</em>(2<em>R</em>)-4-Okso-4-[3-(Trifluorometil)-5,6-dihidro[1,2,4]triazolo[4,3-<em>a</em>]pirazin-7(8<em>H</em>)-il]-1-(2-fluoro-4,6-dihidroksofenil)butan-2-amina</p><p class="BodyAbstract">dengan harga –log IC<sub>50</sub> = 8,601.</p>
Pengembangan Media Pembelajaran pada Pemrograman Terstruktur dan Pemrograman Berorientasi Objek dengan Visualisasi Bangun Datar Menggunakan Processing [Developing Learning Media Instruction on A Structured Programming and An Object-oriented Programming with Two-dimensional Figure Visualization Using Processing]
Authors: Dodi Dodi , Wardah Elvira , Maki Wikky Fawwaz Al 
Published: January 2018

<p class="CPKeyword"><span lang="EN-GB">In general, many people learn structured programming first and then learn object-oriented programming. This makes it difficult for someone to learn object-oriented programming. Because of this difficulty, researchers are interested in developing a learning medium that can display structured programming code and object-oriented code simultaneously and then visualize it with a flat wake object. It is hoped that this learning media can help students in studying object-oriented programming. The type of research used is Research and Development. Questionnaires were distributed to 30 students to find out their response to the media that were developed. The results of this research are displayed in the form of percentages of each aspect on the questionnaire and the percentage of the whole aspect. The results obtained in this research show that structured programming and object-oriented programming that are displayed and visualized simultaneously can help students in understanding object-oriented programming. It can be seen from the percentage obtained during user trials which was 83,33% and for percentage of student response to learning media which was a large as 84,92%.</span></p><p class="CPKeyword"><strong>BAHASA INDONESIA <strong>ABSTRAK</strong>: </strong>Pada umumnya kebanyakan orang mempelajari pemrograman terstruktur terlebih dahulu dan baru kemudian mempelajari pemrograman berorientasi objek. Kebanyakan orang juga mengalami kesulitan dalam mempelajari pemrograman berorientasi objek. Dari permasalahan tersebut peneliti tertarik untuk mengembangkan sebuah media pembelajaran yang dapat menampilkan kode pemrograman terstruktur dan berorientasi objek secara bersamaan kemudian memvisualisasikannya dengan objek bangun datar. Media pembelajaran ini diharapkan dapat membantu seseorang dalam mempelajari pemrograman berorientasi objek. Jenis penelitian ini adalah <em>Research and Development</em>. Angket dibagikan kepada 30 orang mahasiswa untuk mengetahui respons mereka terhadap media pembelajaran yang dikembangkan. Hasil pengolahan data dalam penelitian berupa persentase setiap aspek pada angket dan persentase keseluruhan aspek. Hasil yang didapatkan dalam penelitian ini adalah pemrograman terstruktur dan pemrograman berorientasi objek yang ditampilkan dan divisualisasikan secara bersamaan dapat membantu mahasiswa dalam memahami pemrograman berorientasi objek. Hal tersebut dapat dilihat dari persentase yang didapatkan pada saat uji coba pengguna dengan persentase sebesar 83,33% dan untuk persentase respons mahasiswa terhadap media pembelajaran secara keseluruhan sebesar 84,92%.</p>
Tarımbor ((Na2B8O13.4(H2O)) Gübresinin Sera Koşullarında Tuta absoluta (Meyrick) (Lepidoptera:Gelechiidae)’ya İnsektisit Etkisi ile Domates Bitkisinin Fizyolojisi ve Biyokimyası Üzerindeki Etkilerinin Saptanması
Authors: Kavak Hatice , Tuna Atilla Levent , Civelek Hasan Sungur 
Published: January 2018

&nbsp;

Türkiye’de,
örtüaltı domates üretiminde önemli bir yöre olan Muğla ili Ortaca ilçesinde,
2014&nbsp; Şubat-Mayıs ayları arasında
gerçekleştirilen bu çalışmada Tarımbor (Na2B8O13.4(H2O))
gübresinin Domates galerigüvesi (Tuta
absoluta (Meyrick) (Lepidoptera:
Gelechiidae)) üzerindeki etkisi ile domateste bitki fizyolojisi ve biyokimyası
üzerindeki etkisi araştırılmıştır. Ayrıca, Tarımbor’un domateste bitki
fizyolojisi ve biyokimyası üzerindeki etkisinin saptanması amacıyla yapraklarda
bor, klorofil, karotenoid, prolin, FRAP, CAT, SOD, MDA (lipid peroksidasyonu)
analizleri gerçekleştirilmiştir. Tarımbor
gübresinin beş farklı konsantrasyonu (10, 20, 30, 40, 50 g/da) beş
tekerrürlü olarak denenmiştir. Değerlendirmeler sonucunda genel olarak Tarımbor
gübresinin uygulanan en yüksek konsantrasyonu (TB5) pozitif kontrol olarak
kullanılan Spinosad etken maddesi ile büyük ölçüde aynı grupta yer alarak
domates galerigüvesi mücadelesinde Spinosad’a yakın bir etki göstermiştir.
Tarımbor’un en yüksek konsantrasyonunda bile domates bitkisi yapraklarında
belirlenen Bor kapsamı toksik değerlere ulaşmamıştır. Ayrıca, Tarımbor
konsantrasyonundaki artışa paralel olarak, yapraklarda lipit peroksidasyon
oranının arttığı, bitki antioksidatif sisteminin uyarıldığı ve antioksidatif
enzim aktiviteleri ile prolin kapsamlarının yükseldiği saptanmıştır.
Guest Editorial: E&P Digital Transformation: Fundamental Next Step in Creating Value
Authors: Priyadarshy Satyam 
Published: January 2018

Guest editorial
The adoption of emerging technologies is essential for all businesses, and even more important for well-established industries because of the perpetual threat of disruption from competitors. Industries and companies unable to adopt digital transformation are likely to have a short life span in the current digitally driven global competitive environment. While the E&P industry is more than 100 years old and has seen many ups and downs, the prolonged impact of decreased oil prices since 2014 warrants the need for a transformational modification for it to remain operationally viable.
The upstream sector started the digital journey decades ago, leading to incremental improvements. The first step of this journey is “digitization,” which is the creation of data in digital form. Traditional supervisory control and data acquisition (SCADA) systems, meters, utility line monitors, and other equipment provide digital metrics at different frequencies but there are still many operations that are not fully digital, such as daily drilling reports and log reports.
The second step is “digitalization,” which is leveraging digitized data to generate information with limited value creation such as key performance indicators (KPIs) and dashboards. The industry has created and deployed many of these KPIs and dashboards to assess the health of its business; this “data in motion” is being created with little to no associated provenance, thus creating digitized dark data. In simple terms, dark data are data that exist, but no value is being generated from them. There are many reasons for data to be dark, and for the oil and gas industry the two primary reasons are forgotten data in silos and significant amounts of unused data from past operations.
The final step is the transformational step, “digital transformation,” when the business truly encompasses the transformation of talent, business strategy, and resources by leveraging emerging technologies for real-time resource optimization on an ongoing basis.
Is Your Digitalization Creating Value?
The E&P industry claims to have adopted digitization and digitalization in the form of digital oil fields; however this has failed to generate significant economic value during the past 2 decades. The lack of value creation could be attributed to the following:
Incomplete use or nonuse of data-driven innovation
Use of inefficient, complex, and fragmented workflows
Inability to keep pace with the information technology (IT) revolution
Investigating the Et-1/SphK/S1P Pathway as a Novel Approach for the Prevention of Inflammation-Induced Preterm Birth
Authors: Giusto Kiersten , Ashby Charles R. 
Published: January 2018

Background:
Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, occurs in
up to 18 percent of births worldwide and accounts for the majority of perinatal morbidity and mortality. While the
single most common cause of PTB has been identified as inflammation, safe and effective pharmacotherapy to
prevent PTB has yet to be developed.

Methods:
Our group has used an in vivo model of inflammation-driven PTB, biochemical methods, pharmacological
approaches, a novel endothelin receptor antagonist that we synthesized and RNA knockdown to help establish
the role of endothelin-1 (ET-1) in inflammation-associated PTB. Further, we have used our in vivo model to
test whether sphingosine kinase, which acts downstream of ET-1, plays a role in PTB.

Results:
We have shown that levels of endothelin converting enzyme-1 (ECE-1) and ET-1 are increased when
PTB is induced in timed pregnant mice with lipopolysaccharide (LPS) and that blocking ET-1 action, pharmacologically
or using ECE-1 RNA silencing, rescues LPS-induced mice from PTB. ET-1 activates the sphingosine
kinase/sphingosine-1-phosphate (SphK/S1P) pathway. S1P, in turn, is an important signaling molecule in the proinflammatory
response. Interestingly, we have shown that SphK inhibition also prevents LPS-induced PTB in
timed pregnant mice. Further, we showed that SphK inhibition suppresses the ECE-1/ET-1 axis, implicating
positive feedback regulation of the SphK/S1P/ECE-1/ET-1 axis.

Conclusion:
The ET-1/SphK/SIP pathway is a potential pharmacotherapeutic target for the prevention of PTB.
BONY TUMOURS OF MAXILLOFACIAL REGION : RETROSPECTIVE STUDY OF CLINICO-PATHOLOGICAL PROFILE AND THEIR MANAGEMENT
Authors: Dadoo Shubham , Sharma Rohit , Sharma Vineet , Soni Annanya 
Published: January 2018

Introduction: Maxillo-facial tumours are a group of heterogenous diseases that ranges from
hamartomas or non-neoplastic tissue proliferations to benign neoplastic to malignant tumors
with metastatic potentials. The aim of the present study is to evaluate the clinico-pathological
profile and management of primary lesions of facio-maxillary region.
Material and Methods: Retrospective data of bony tumors of maxilla-facial region was
retrieved for 2 years from March 2015 to April 2017. The data included the gender, age,
diagnosis based on radiology, histopathology and the site of origin.
Results: A total of 18 patients were diagnosed as a bony tumour of maxillofacial region and
treated surgically. Fibrous dysplasia, Odontogenic cyst and Ameloblastoma were the most
common lesions.
Conclusion: Bony tumours of Maxillofacical region though uncommon and mostly benign,
pose a great challenge to preserve the functions and cosmesis.
Estudo sobre lubrificação em rolamentos e desenvolvimento de um tribômetro método reichert
Authors: Mendes de Souza Alan , Ap. Ferraz da Silva Fabrício , Amade de Souza Felipe , Humberto Sartori Carlos , Alberto de Freitas Carlos , Carlos Arruda Antonio 
Published: January 2018

O estudo se destina a abordagem das possíveis falhas em elementos de máquinas (rolamentos) fabricados em AISI 52100 e seus principais mecanismos de desgaste sendo adesão, abrasão, corrosão e fadiga. Serão apresentados os principais tipos de lubrificantes, dando ênfase nos óleos e graxas quanto a suas características físico-químicas e seus principais aditivos. Para viabilidade do estudo foi desenvolvido um dispositivo que realizou ensaios em um mesmo lubrificante de viscosidade 15W4-50 com períodos de utilização distintos sendo estes 1000, 2000 e 3000 km, desta forma foi possível medir o rompimento da película de lubrificação em função da pressão exercida pelo dispositivo e sendo assim exemplificar de maneira efetiva os efeitos danosos aos elementos de máquinas em função da má gestão da lubrificação.
Earnings management and the floatation structure: empirical evidence from Polish IPOs
Authors: Sosnowski Tomasz 
Published: January 2018

Research background: Firms use discretionary accounting choices to manage earnings disclosures around the time of certain types of corporate events. The initial public offering particularly provides an opportunity to earnings management because of the significant information asymmetry between investors and issuers at the time of the offering.
Purpose of the article: The main aim of the study is to empirically investigate the links between the earnings management and the portions of primary and secondary shares sold in IPO.
Methods: In order to investigate whether the earnings management influences the issue of new shares and the sale of secondary shares I use Tobit and logit regressions, where discre-tionary accruals are the proxy for earnings management.
Findings & Value added: Using a sample of 221 firms from Warsaw Stock Exchange between 2005 and 2015 I do not find evidence that the increase of pre-IPO discretionary accruals positively affects the sale of primary shares in the IPO, but the analysis has revealed that the deliberate conservative reporting limits the probability of the new shares issuance. In turn, the sale of secondary shares by the original shareholders in IPO is more likely in companies using a conservative earnings management. Furthermore, negative discretionary accruals increase the portion of secondary shares sold in the IPO.