bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative cytogenetics of kenaf (Hibiscus cannabinus L.) breeding lines reveal chromosomal variability and instability
Authors: Ankrah Nii-Ayi , El-nagish Abdullah , Breitenbach Sarah , Tetteh Antonia Y. , Heitkam Tony 
Published: September 2024

AbstractKenaf (Hibiscus cannabinus), a native warm-seasonal crop in Africa, is being considered for genetic improvement for local bast fiber production. To expedite its genetic improvement through breeding, kenaf genotypes from Ghana were assessed for genomic diversity regarding their chromosomal composition and ploidy levels. To gain insight into the repetitive DNA fractions in kenaf, the organization of 5S and 35S rRNA genes, as well as telomeric signal patterns were studied by a molecular cytogenetic approach. Using multi-color fluorescent in situ hybridization, distinct rDNA loci and Arabidopsis-like telomere signal patterns were revealed. The 5S rRNA genes were conserved in kenaf and localized in interstitial regions of two chromosomes across all accessions. The 35S rRNA genes were variable across the kenaf accessions and localized at sub-terminal ends and rarely interstitially in eight or six chromosome arms. Telomeric signals were observed at terminal ends of all chromosomes and the chromosome configuration of Ghana kenaf accessions were each confirmed to be 2n = 2x = 36. Observed genomic instability in kenaf is discussed. This report provides cytogenetic insights into the genome organization of kenaf and variability of its breeding lines. Additionally, this study sets the basis for further research to analyze the repetitive DNA sequences and develop reference karyotypes to reveal genetic and evolutionary relationships between cultivated and wild Hibiscus species.
On convergence of a q-random coordinate constrained algorithm for non-convex problems
Authors: Ghaffari-Hadigheh A. , Sinjorgo L. , Sotirov R. 
Published: September 2024

AbstractWe propose a random coordinate descent algorithm for optimizing a non-convex objective function subject to one linear constraint and simple bounds on the variables. Although it is common use to update only two random coordinates simultaneously in each iteration of a coordinate descent algorithm, our algorithm allows updating arbitrary number of coordinates. We provide a proof of convergence of the algorithm. The convergence rate of the algorithm improves when we update more coordinates per iteration. Numerical experiments on large scale instances of different optimization problems show the benefit of updating many coordinates simultaneously.
A Descent Method for Nonsmooth Multiobjective Optimization in Hilbert Spaces
Authors: Sonntag Konstantin , Gebken Bennet , Müller Georg , Peitz Sebastian , Volkwein Stefan 
Published: September 2024

AbstractThe efficient optimization method for locally Lipschitz continuous multiobjective optimization problems from Gebken and Peitz (J Optim Theory Appl 188:696–723, 2021) is extended from finite-dimensional problems to general Hilbert spaces. The method iteratively computes Pareto critical points, where in each iteration, an approximation of the Clarke subdifferential is computed in an efficient manner and then used to compute a common descent direction for all objective functions. To prove convergence, we present some new optimality results for nonsmooth multiobjective optimization problems in Hilbert spaces. Using these, we can show that every accumulation point of the sequence generated by our algorithm is Pareto critical under common assumptions. Computational efficiency for finding Pareto critical points is numerically demonstrated for multiobjective optimal control of an obstacle problem.
Procedural volume is linearly associated with mortality, major complications, and readmissions in patients undergoing malignant brain tumor resection
Authors: Han Jane S. , Wenger Talia , Demetriou Alexandra N. , Dallas Jonathan , Ding Li , Zada Gabriel , Mack William J. , Attenello Frank J. 
Published: September 2024

Abstract
Purpose
Improved outcomes have been noted in patients undergoing malignant brain tumor resection at high-volume centers. Studies have arbitrarily chosen high-volume dichotomous cutoffs and have not evaluated volume-outcome associations at specific institutional procedural volumes. We sought to establish the continuous association of volume with patient outcomes and identify cutoffs significantly associated with mortality, major complications, and readmissions. We hypothesized that a linear volume-outcome relationship can estimate likelihood of adverse outcomes when comparing any two volumes.

Methods
The patient cohort was identified with ICD-10 coding in the Nationwide Readmissions Database(NRD). The association of volume and mortality, major complications, and 30-/90-day readmissions were evaluated in multivariate analyses. Volume was used as a continuous variable with two/three-piece splines, with various knot positions to reflect the best model performance, based on the Quasi Information Criterion(QIC).

Results
From 2016 to 2018, 34,486 patients with malignant brain tumors underwent resection. When volume was analyzed as a continuous variable, mortality risk decreased at a steady rate of OR 0.988 per each additional procedure increase for hospitals with 1–65 cases/year(95% CI 0.982–0.993, p < 0.0001). Risk of major complications decreased from 1 to 41 cases/year(OR 0.983, 95% CI 0.979–0.988, p < 0.0001), 30-day readmissions from 1 to 24 cases/year(OR 0.987, 95% CI 0.979–0.995, p = 0.001) and 90-day readmissions from 1 to 23 cases/year(OR 0.989, 95% CI 0.983–0.995, p = 0.0003) and 24–349 cases/year(OR 0.9994, 95% CI 0.999–1, p = 0.01).

Conclusion
In multivariate analyses, institutional procedural volume remains linearly associated with mortality, major complications, and 30-/90-day readmission up to specific cutoffs. The resulting linear association can be used to calculate relative likelihood of adverse outcomes between any two volumes.
Neuromedin U Neurons in the Edinger–Westphal Nucleus Respond to Alcohol Without Interfering with the Urocortin 1 Response
Authors: Medrano Mireia , Allaoui Wissal , Haddad Ra’fat Ehab Salim , Makrini-Maleville Leila , Valjent Emmanuel , Smolders Ilse , Kormos Viktória , Gaszner Balázs , De Bundel Dimitri 
Published: September 2024

AbstractThe Edinger–Westphal nucleus (EW) is a midbrain nucleus composed of a preganglionic, cholinergic subpopulation and a densely clustered peptidergic subpopulation (EWcp). The EWcp is one of the few brain regions that show consistent induction of FOS following voluntary alcohol intake. Previous results in rodents point to urocortin 1 (UCN1) as one of the peptides most involved in the control of ethanol intake and preference. Notably, the functions described for UCN1, such as reward processing, stress coping or the regulation of feeding behavior are similar to those described for the neuropeptide neuromedin U (NMU). Interestingly, NMU has been recently associated with the modulation of alcohol-related behaviors. However, little is known about the expression and functionality of NMU neurons in alcohol-responsive areas. In this study, we used the recently developed Nmu-Cre knock-in mouse model to examine the expression of NMU in the subaqueductal paramedian zone comprising the EWcp. We delved into the characterization and co-expression of NMU with other markers already described in the EWcp. Moreover, using FOS as a marker of neuronal activity, we tested whether NMU neurons were sensitive to acute alcohol administration. Overall, we provided novel insights on NMU expression and functionality in the EW region. We showed the presence of NMU within a subpopulation of UCN1 neurons in the EWcp and demonstrated that this partial co-expression does not interfere with the responsivity of UCN1-containing cells to alcohol. Moreover, we proposed that the UCN1 content in these neurons may be influenced by sex.
Can pots be an alternative fishing gear to gillnets? A Mediterranean case study
Authors: Virgili M. , Petetta A. , Herrmann B. , Cerbule K. , Guicciardi S. , La Manna G. , Malvarosa L. , Li Veli D. , Barone G. , Lucchetti A. 
Published: September 2024

AbstractSmall-scale coastal fisheries in the Mediterranean often employ gillnets, a widely used gear worldwide. The disadvantages of gillnets in this fishery include high bycatch levels of unwanted species and consequent discards. Moreover, spatial conflict with other gears and dolphin depredation often results in considerable economic loss. Alternative fishing methods are being tested. This study investigated whether, in small-scale fisheries in the Adriatic Sea, pots can ensure sustainable harvest of mantis shrimp (Squilla mantis), a major target demersal species in terms of landings, and possibly replace traditional gillnets. We adopted a multidisciplinary approach to investigate the catch efficiency, biological impact, and socio-economic effects of the two fishing methods. We found different species compositions in gillnet and pot catches. Gillnets yielded a greater number of discarded species of no commercial value, whereas pots caught a greater amount of mantis shrimp. Finally, a profit analysis indicated that pot fishery has the potential to increase profits for the commercial fishing industry. This study suggests that pots provide a more sustainable fishing method, both in terms of revenue and environmental impact.
High prevalence and genetic heterogeneity of adenoviruses at a psittacine breeding facility
Authors: Lizzi Gabriele , Fasana Simone , Grilli Guido , Quaglia Giulia , Pedrazzoli Sara , Graziosi Giulia , Catelli Elena , Musa Laura , Rapi Maria Cristina , Lupini Caterina 
Published: September 2024

AbstractA polymerase chain reaction (PCR) survey was performed at an amateur parrot breeding facility in Italy to investigate the presence and molecular characteristics of adenoviruses. Eighty psittacine birds, belonging to seven parrot species, were sampled by cloacal swabs; in addition, 15 livers were collected from specimens that were found dead. Seventy-two out of 95 samples collected were positive for adenoviruses, with a prevalence rate of 75.8%. All seven psittacine species tested positive for at least one genus of the family Adenoviridae; notably, adenoviral infection was found for the first time in the hooded parrot (Psephotellus dissimilis). Based on the sequences and phylogenetic analysis, 57 sequences were psittacine adenovirus 2, seven sequences were duck adenovirus 1 and two sequences were identified as psittacine adenovirus 5. The six remaining sequences showed low nucleotide and amino acid identity with the reference strains of accepted species or types, revealing the presence of novel adenoviruses belonging to the genera Aviadenovirus, Barthadenovirus and Siadenovirus. There were identical adenovirus sequences in both apparently healthy and dead birds suggesting that further investigation into the role and impact of these viruses on the health of psittacine birds is warranted.
Open science practices in criminology and criminal justice journals
Authors: Greenspan Rachel Leigh , Baggett Logan , B. Boutwell Brian 
Published: September 2024

Abstract
Objective
Calls for more transparent and replicable scientific practices have been increasing across scientific disciplines over the last decade, often referred to as the open science movement. Open science practices are arguably particularly important in fields like criminology and criminal justice where empirical findings aim to inform public policy and legal practice. Despite favorable views of these practices by criminal justice scholars, limited research has explored how often researchers actually use these open science practices.

Method
The current study measures the reported use of pre-registration, open access, open materials, open data, and open code in leading criminology and criminal justice journals from 2018 to 2022.

Results
Our results reveal limited use of open science practices, particularly pre-registration and open code.

Conclusions
Given these findings, we call for both journals and authors to consider adopting these practices to move toward a more transparent and replicable field.
Cortinarius steglichii: a taxonomical and chemical novelty from Chile
Authors: Lam Yen T. H. , Schmitz Lea , Huymann Lesley , Dhar Dipendu , Morgan Ibrahim , Rennert Robert , Davari Mehdi D. , Peintner Ursula , Palfner Götz , Arnold Norbert 
Published: September 2024

AbstractThe new species Cortinarius steglichii is described from Chilean Nothofagus forest based on morphological and microscopical attributes, molecular phylogeny, and chemical analysis of secondary metabolites. C. steglichii is characterized by abundant, long, ramified cystidia on the lamellar edges and stipe apex, further by a deep violet color reaction after treatment with KOH. As responsible secondary metabolite for the cytoplasmatic color reaction of cystidia and some hyphae, the new diterpenoid steglichon (1) could be recognized, showing also remarkable antibacterial and anticancer activity. Phylogenetic analyses (ITS, LSU, RPB1) confirm the close relationship to species of the Cortinarius dulciolens group.
Prognostic thresholds of outcome predictors in severe accidental hypothermia
Authors: Mendrala Konrad , Darocha Tomasz , Brožek Tomáš , Kosiński Sylweriusz , Balik Martin , Cools Evelien , Walpoth Beat , Nowak Ewelina , Dąbrowski Wojciech , Miazgowski Bartosz , Reszka Kacper , Rutkiewicz Aleksander , Debaty Guillaume , Segond Nicolas , Dudek Michał , Górski Stanisław , Podsiadło Paweł 
Published: September 2024

AbstractHemodynamically unstable patients with severe hypothermia and preserved circulation should be transported to dedicated extracorporeal life support (ECLS) centers, but not all are eligible for extracorporeal therapy. In this group of patients, the outcome of rewarming may sometimes be unfavorable. It is, therefore, crucial to identify potential risk factors for death. Furthermore, it is unclear what criterion for hemodynamic stability should be adopted for patients with severe hypothermia. The aim of this study is to identify pre-rewarming predictors of death and their threshold values in hypothermic patients with core temperature ≤ 28 °C and preserved circulation, who were treated without extracorporeal rewarming. We conducted a multicenter retrospective study involving patients in accidental hypothermia with core temperature 28 °C or lower, and preserved spontaneous circulation on rewarming initiation. The data were collected from the International Hypothermia Registry, HELP Registry, and additional hospital data. The primary outcome was survival to hospital discharge. We conducted a multivariable logistic regression and receiver operating characteristic curve (ROC) analysis. In the multivariate analysis of laboratory tests and vital signs, systolic blood pressure (SBP) adjusted for cooling circumstances and base excess (BE) were identified as the best predictor of death (OR 0.974 95% CI 0.952–0.996), AUC ROC 0.79 (0.70–0.88). The clinically relevant cutoff for SBP was identified at 90 mmHg with a sensitivity of 0.74 (0.54–0.89) and a specificity of 0.70 (0.60–0.79). The increased risk of death among hypothermic patients with preserved circulation occurs among those with an SBP below 90 mmHg and in those who developed hypothermia in their homes.
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury
Authors: Wang Yuebing , Harada Sayaka , Goshima Yoshio , Ohshima Toshio 
Published: September 2024

AbstractAs the primary connection between the eye and brain, the optic nerve plays a pivotal role in visual information transmission. Injuries to the optic nerve can occur for various reasons, including trauma, glaucoma, and neurodegenerative diseases. Retinal ganglion cells (RGCs), a type of neurons that extend axons through the optic nerve, can rapidly respond to injury and initiate cell death. Additionally, following optic nerve injury microglia, which serve as markers of neuroinflammation, transition from a resting state to an activated state. The phosphorylation of collapsin response mediator protein2 (CRMP2) in the semaphorin 3A (Sema3A) signalling pathway affects several processes, including axon guidance and neuron regeneration. In this study, we used an optic nerve crush (ONC) mouse model to investigate the effects of suppressing CRMP2 phosphorylation on microglia activation. We found that CRMP2 phosphorylation inhibitor suppressed RGCs loss and promoted neuronal regeneration following ONC. In addition, CRMP2 S522A mutant (CRMP2 KI) mice exhibited decreased microglial activation in both the retina and optic nerve following ONC. These results suggest that inhibiting the phosphorylation of CRMP2 can alleviate the loss of RGCs and microglial activation after optic nerve injury, providing insight into the development of treatments for optical neuropathies and neurodegenerative diseases.
The Impact of Sedative Choice in the Management of Aneurysmal Subarachnoid Hemorrhage: A Scoping Review
Authors: Then James , Tawfik Samuel , Law Timothy , Brown Alastair , Carnegie Vanessa , Udy Andrew , Jeffcote Toby 
Published: September 2024

AbstractAneurysmal subarachnoid hemorrhage (aSAH) is characterized by high mortality and morbidity. This scoping review assesses the current evidence regarding the use of sedatives and analgesics in the acute intensive care unit management of aSAH. We conducted a systematic search of Ovid MEDLINE, Ovid Embase, Ovid EmCare, APA PsycInfo, CINAHL, and the Cochrane Database of Systematic Reviews from inception to June 2023. Studies were included if they enrolled intensive care unit patients aged 18 or older with a significant proportion (> 20%) who had aSAH and evaluated the impact of one or more commonly used analgosedatives on physiological parameters in the management of aSAH. The methodological quality of the studies was assessed using the Methodological Index for Nonrandomized Studies score. Of 2,583 articles, 11 met the inclusion criteria. The median sample size was 47 (interquartile range 10–127), and the median Methodological Index for Nonrandomized Studies score was 9.5 (interquartile range 8–11). The studies’ publication years ranged from 1980 to 2023. Dexmedetomidine and ketamine showed potential benefits in reducing the incidence of cortical spreading depolarization and delayed cerebral ischemia. Propofol and opioids appeared safe but lacked robust evidence for efficacy. Benzodiazepines were associated with increased delayed cerebral ischemia–related cerebral infarctions and cortical spreading depolarization events. The evidence available to guide the use of analgosedative medications in aSAH is critically inadequate. Dexmedetomidine and ketamine warrant further exploration in large-scale prospective studies because of their potential benefits. Improved study designs with consistent definitions and a focus on patient-centered outcomes are necessary to inform clinical practice.
Recommendations from the Galician Oncological Society and the Galician Society of Nuclear Medicine for the use of 177Lu-PSMA-617 radioligand-therapy in prostate cancer
Authors: Fernández Calvo Ovidio , Muñoz Iglesias José , Abou Jokh Casas Estephany , Molina-Díaz Aura , Anido Herranz Urbano , Casas Nebra Javier , García-Bernardo Lucía , Martínez-Breijo Sara , Lázaro-Quintela Martín , Muñiz-García Gloria , Vázquez-Estevez Sergio 
Published: September 2024

ABSTRACT
Theragnostic is a type of precision medicine that uses molecules linked to radioactive isotopes for the diagnosis and treatment of diseases. In recent years, it has gained significant importance to treat neuroendocrine tumors and is currently being used in prostate cancer. Various radiopharmaceuticals have emerged for diagnosing and detecting lesions showing prostate-specific membrane antigen (PSMA) positivity on the Positron emission tomography/computed tomography scan, being the most widely used labeled with [68Ga] and [18F]. Its use as therapy in prostate cancer (PC) has been assessed in the VISION, TheraP, and PSMAfore clinical trials conducted with the radioligand [177Lu]Lu-PSMA-617, demonstrating significant antitumor activity. The aim of this article is to present practical recommendations, based on current available scientific evidence and on a multidisciplinary consensus, for the diagnosis and treatment with [177Lu]Lu-PSMA-617 in patients with PC.
Failing successfully? Local referendums and ENGOs’ lawsuits as challenges to wind energy expansion in Germany
Authors: Töller Annette Elisabeth , Garske Benjamin , Rasch Daniel , Weigel Alix , Hahn Hanno 
Published: September 2024

AbstractGermany is implementing the “Energiewende” (energy transition): it has completed the phase-out of nuclear energy and plans to phase out coal-fired power generation by 2038 at the latest. The expansion of renewable energies is thus an imperative task and wind energy capacity must be increased significantly. However, wind energy expansion has slumped massively since 2018 and is only slowly catching up. Various reasons for this gap between necessity and reality are proposed, with citizens’ referendums on local decisions as well as lawsuits brought by Environmental Non-Governmental Organisations (ENGOs) against approval decisions being relevant obstacles. However, data on how these projects challenge wind energy expansion is lacking so far. The article addresses this gap and examines how, to what extent, and with what effect these procedures are used by opponents of wind energy projects. Focusing on Hesse as a state where both procedures are used comparatively often, the article takes stock conceptually and empirically of their role and impact, drawing on secondary literature and initial collections of descriptive primary data to look at how these procedures result in producing obstacles to local wind energy expansion. Findings from case studies suggest that both procedures may hinder wind energy expansion even if, in formally legal terms, they are not ultimately successful. From the perspective of local opponents of specific wind energy projects, this offers the possibility of “failing successfully”.