bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wii Fit Exercise’s Effects on Muscle Strength and Fear of Falling in Older Adults With Alzheimer Disease: A Randomized Controlled Trial
Authors: Uğur Fatma , Sertel Meral 
Published: October 2024

Purpose: This study aimed to investigate how Wii Fit exercises affect muscle strength and fear of falling in older adults with Alzheimer’s disease. Method: The study included a total of 32 volunteers with Alzheimer’s disease, aged 65–80 years. These participants were divided into two groups: the exercise group and the control group. The exercise group received a 30-min (one session) twice-weekly exercise program for 6 weeks with games selected from different categories, such as balance and aerobic exercises, with the Nintendo Wii virtual reality device. During this period, the control group did not receive any treatment, and routine medical treatments continued. At baseline and 6 weeks later, Mini-Mental State Examination, knee extension muscle strength, Timed Up and Go Test, and Tinetti Fall Efficacy Scale results were recorded in the exercise and control groups. Results: In intragroup comparison, a statistically significant difference was found in all tests (muscle strength, Timed Up and Go Test, and Tinetti Fall Efficacy Scale) in the exercise group after the exercise program (p < .05), while no significant difference was found in the control group (p > .05). According to the interaction of group and time in the intergroup comparison, there was no difference between the groups (exercise and control group) in muscle strength and Timed Up and Go Test (p > .05), but there was a difference in Tinetti Fall Efficacy Scale (p < .05). Conclusions: This randomized controlled trial supports the claim that Wii Fit exercises can reduce the fear of falling in older adults with Alzheimer’s disease.
Sitting, Standing, and Physical Activity in Australian Passenger Rail Drivers: On the Right Track for Better Health?
Authors: Chappel Stephanie E. , Rasmussen Charlotte L. , Vandelanotte Corneel , Chapman Janine , Holtermann Andreas , Naweed Anjum , Straker Leon 
Published: October 2024

Background: Poor health in passenger rail drivers, resulting from perceived highly sedentary work and leisure time, has implications for public safety. To date, no studies have described the physical behaviors of passenger rail drivers. This study aimed to characterize the physical behaviors of passenger rail drivers by investigating the volume, pattern, variation, and composition of behaviors at and outside of work. Methods: A convenience sample of 31 rail drivers (77% male, median age 51.0 [12.5] y) in South Australia wore an activity monitor on their right thigh for 8 days and completed a work logbook. Physical behaviors (sitting, standing, light-intensity physical activity, moderate- to vigorous-intensity physical activity [MVPA], and steps) were recorded for workdays and nonworkdays, and work and nonwork time on workdays. The volume, bouts, between-participants variation, and 3-way composition were compared across the 4 time periods. Results: Drivers sat for 10.6 (1.5) hours, did 76.3 (38.8) minutes of MVPA, and took 9727.3 (4088.4) steps daily. At work, drivers were sitting 369.3 (41.8) minutes (187.1 [54.2] min in prolonged bouts) and doing MVPA 31.7 (10.0) minutes. Between-participants variation in sitting time during work (11%) was lower than both nonwork on a workday (19%) and on a nonworkday (24%; P < .001). Compositions at work differed from nonwork on workdays (F = 27.7, P < .001), as did compositions on workdays compared with nonworkdays (F = 6.8, P = .002). Conclusions: Passenger rail drivers were highly sedentary, but also surprisingly active. At work, drivers were more sedentary and had lower variation in behaviors, suggesting work constraints play an important role. Therefore, work may be the most appropriate domain to intervene for promoting healthy physical behavior profiles among these passenger rail drivers.
Association of the gut microbiome and different phenotypes of COPD and asthma: a bidirectional Mendelian randomization study
Authors: Wang Zihan , Qu Jingge , Chang Chun , Sun Yongchang 
Published: October 2024

ABSTRACT

Mounting evidence has revealed the association between gut microbiota and both chronic obstructive pulmonary disease (COPD) and asthma; however, the causal association between gut microbiota and specific disease phenotypes remains to be determined. This study employed bidirectional two-sample Mendelian randomization (MR) analyses to investigate the potential causal relationship between gut microbiota and these conditions. The research utilized genome-wide association study (GWAS) data from the MiBioGen consortium for gut microbiota and the integrative epidemiology unit (IEU) Open GWAS for these conditions. Four MR analysis methods were employed: the inverse variance weighted (IVW) test, MR-Egger, weighted median, and weighted mode methods. The IVW method results are considered the primary findings. Sensitivity analyses, including heterogeneity tests, horizontal pleiotropy analysis, and leave-one-out analysis, were used to enhance robustness. Our MR study identified eight gut microbiota taxa potentially associated with the risk of different types of COPD and asthma. These include two taxa for early-onset COPD:
Streptococcaceae
[odds ratio (OR) = 1.315, 95% confidence interval (CI) = 1.071–1.616,
P
= 0.009] and
Holdemanella
(OR = 1.199, 95% CI = 1.063–1.352,
P
= 0.003); three for later-onset COPD:
Acidaminococcaceae
(OR = 1.312, 95% CI = 1.098–1.567,
P
= 0.003),
Holdemania
(OR = 1.165, 95% CI = 1.039–1.305,
P
= 0.009), and
Marvinbryantia
(OR = 0.814, 95% CI = 0.697–0.951,
P
= 0.009); one for allergic asthma:
Butyricimonas
(OR = 0.794, 95% CI = 0.693–0.908,
P
= 0.001); and two for non-allergic asthma:
Clostridia
(OR = 1.255, 95% CI = 1.043–1.511,
P
= 0.016) and
Clostridiales
(OR = 1.256, 95% CI = 1.048–1.506,
P
= 0.014).

IMPORTANCE
Individuals with diverse phenotypes of chronic obstructive pulmonary disease (COPD) and asthma exhibit different responses to the conventional “one treatment fits all” approach. Recent research has revealed the significant role of the gut-lung axis in both COPD and asthma. However, the specific impact of gut microbiota on different subtypes of these conditions remains poorly understood. Our study has identified eight gut microbiota that may be associated with the risk of different types of COPD and asthma. These findings provide evidence suggesting a potential causal relationship between gut microbiota and various phenotypes of COPD and asthma. This offers a new perspective on the origins of different disease phenotypes and points toward future exploration of phenotype-specific and personalized therapies.
The Holleford structure: Insights into the pre- and post-impact geology of the Frontenac Terrane, Canada
Authors: McGregor Maree , Spray John G. , Dence Michael R. , McFarlane Christopher R.M. , van Soest Matthijs C. 
Published: October 2024

Abstract
A multi-chronometric investigation has been conducted on the ~2.0-km-diameter Holleford impact structure of Ontario, Canada. In situ triple quadrupole laser ablation–inductively coupled–mass spectrometry U-Pb and Rb-Sr geochronology, along with (U-Th)/He thermochronology, have been applied to multiple mineral phases from impact melt-bearing breccias and overlying sedimentary units. Impact-induced resetting is absent in all three isotopic systems. While Holleford’s small size resulted in insufficient heating to reset geochronometers during impact, our investigation has defined a more detailed pre- and post-impact geologic setting within the Precambrian basement and overlying Paleozoic lithologies. Target rock age determinations include those associated with the Proterozoic Frontenac Terrane. These are manifest as the Rigolet (1004 ± 5 Ma, U-Pb apatite dating) and Ottawan (1074 ± 12 Ma, Rb-Sr biotite dating) phases of the Grenville Orogeny. Pre-Grenville ages associated with the Penokean (1806 ± 46 Ma, apatite dating) and the Shawinigan (1184 ± 8 Ma, U-Pb titanite dating; 1134 ± 21 Ma, U-Pb zircon dating) orogenies are also retained. A Paleoproterozoic age records Superior Province tectonometamorphism (2421 ± 97 Ma, U-Pb zircon dating). Dated post-impact events include dolomitization associated with Silurian marine transgression (430 ± 14 Ma, U-Pb dolomite dating) and regional K-metasomatism of Mississippian age (346 ± 5 Ma, U-Pb titanite dating). Extremely young (U-Th)/He ages (27–3 Ma) were obtained from planar fractured and recrystallized apatite, which we interpret to be the result of impact-induced diffusion domain reduction. This, combined with low-temperature heating due to burial, significantly limited He retention. Stratigraphic constraints place the Holleford impact event at ca. 458 Ma, close to the Darriwilian–Sandbian boundary of the Ordovician. This age indicates that Holleford may be part of the Late Ordovician group of terrestrial impact craters related to L-chondrite parent breakup.
Long-term surgical outcomes and prognostic factors for advanced-stage retinopathy of prematurity after vitrectomy
Authors: Chang Yin-Hsi , Kang Eugene Yu-Chuan , Chen Kuan-Jen , Wang Nan-Kai , Liu Laura , Hwang Yih-Shiou , Lai Chi-Chun , Wu Wei-Chi 
Published: October 2024

Background/aims
The aims of this study is to evaluate the anatomic, visual outcomes and associated prognostic factors in patients with advanced retinopathy of prematurity (ROP) following vitrectomy.

Methods
A retrospective cohort study of patients with ROP who underwent vitrectomy from 2005 to 2016 was conducted. All the patients had a follow-up period of at least 5 years. Univariate and multivariable logistic regression analyses were used to explore the factors related to unfavourable outcomes.

Results
In total, 81 eyes of 51 patients were included. The mean age at last follow-up was 10.2 years. The anatomic success rate was 96.3% (26/27) for stage 4A, 90.9% (20/22) for stage 4B and 31.3% (10/32) for stage 5 ROP (p<0.01). The mean logMAR best corrected visual acuity of the stage-4A eyes was the highest, followed by those of stage-4B and stage-5 eyes (0.8, 1.5 and 2.6 for stages 4A, 4B and 5, respectively; p<0.01). High myopia (≤ −5.0 D) was noted in 70.8% and 71.4% of stage-4A and stage-4B eyes, respectively. Cataract was the most common complication (25.9%), followed by corneal opacity (17.3%), strabismus (16.1%), and phthisis (16.1%). Stage of the disease was a poor prognostic factor in all vitrectomised eyes (p<0.01). Vitrectomy combined lensectomy was a significant predictor for poor anatomic outcomes for stage-4 eyes (p=0.03). Presence of plus disease was also a possible factor affecting the surgical outcomes.

Conclusion
The long-term surgical outcomes of the eyes with stage 4A and 4B ROP were favourable. Management of stage 5 ROP remained challenging.
Noisy knees - knee crepitus prevalence and association with structural pathology: a systematic review and meta-analysis
Authors: Couch Jamon L , King Matthew G , De Oliveira Silva Danilo , Whittaker Jackie L , Bruder Andrea M , Serighelli Fernanda , Kaplan Sean , Culvenor Adam G 
Published: October 2024

ObjectiveKnee crepitus, the audible crackling or grinding noise during knee movement, can be experienced across the lifespan and create concern for underlying pathology. Our systematic review aims to provide a summary estimate of knee crepitus prevalence and its association with structural pathology among the general population and across knee conditions.DesignSystematic review and meta-analysis.Data sourcesMedline, Embase, CENTRAL, Web of Science, SPORTDiscus and CINAHL.Eligibility criteriaStudies evaluating knee crepitus prevalence.Results103 studies involving 36 439 participants (42 816 knees) were included. Based on very low certainty evidence, the pooled prevalence of knee crepitus in the general population was 41% (7609 knees; 95% CI 36% to 45%; I2=92.6%); in pain-free persons 36% (852 knees; 95% CI 23% to 50%; I2=91.9%), and in those with osteoarthritis (OA) 81% (18 821 knees; 95% CI 75% to 87%; I2=97.9%). Across other musculoskeletal knee conditions, the pooled prevalence of knee crepitus ranged from 35% (ligament injury; 2740 knees; 95% CI 27% to 44%; I2=95.6%) to 61% (cartilage pathology; 1445 knees; 95% CI 40% to 81%; I2=98.2%). There was low to very low certainty evidence of an association between knee crepitus and radiographic OA (OR 3.79, 95% CI 1.99 to 7.24; 1725 knees; I2=53.0%) and several OA-related features on magnetic resonance imaging (MRI).ConclusionIn this review, knee crepitus was prevalent in the general population, pain-free persons, those with knee OA and other musculoskeletal knee conditions. Knee crepitus was associated with a more than threefold increased odds of radiographic OA diagnosis and several OA-related MRI features. The low to very low certainty of evidence informing our aggregated prevalence estimates and association outcomes suggest that results should be interpreted with caution.
Effects of freebase/protonated nicotine concentration, liquid composition and electrical power on throat hit in direct-to-lung vaping: theory and clinical measurements
Authors: El Hourani Mario , Lakkis Issam , Ammar Maram , AlGemayel Christina , Talih Soha , Golshahi Laleh , Hosseini Sana , Ashley David , Saleh Rawad , Eissenberg Thomas , Breland Alison , Shihadeh Alan 
Published: October 2024

BackgroundFor decades, the tobacco industry has engineered the sensory characteristics of combustible tobacco products including the degree of harshness experienced at the back of the throat. Commonly referred to as ‘throat hit’, this harshness derives from absorption of gas phase nicotine and other constituents by the sensory nerves. People who use tobacco products associate throat hit with the positive psychological effects of nicotine, making it a secondary reinforcer for smoking. On the other hand, high throat hit can make products aversive to naïve nicotine users and serves as a barrier to consumption of tobacco products.MethodsWe developed a first-principles theoretical model to predict nicotine absorption in the throat as a function of electronic nicotine delivery systems (ENDS) device power, liquid composition and puffing topography. The predicted nicotine absorption was compared with subjective throat harshness reported by human participants. We also simulated several ENDS use scenarios to identify the most important processes and factors that govern nicotine absorption in the throat.ResultsAcross various ENDS configurations, we found that computed nicotine gas absorption in the throat was associated with subjective harshness scores (r=0.62; p<0.00001). We also found that liquid nicotine concentration, nicotine form, aerosol temperature and inhalation rate strongly influence nicotine absorption in the throat per unit of nicotine emitted by an ENDS.ConclusionsNicotine throat hit can be predicted and manipulated through ENDS device and liquid design variables. Regulating ENDS throat hit is feasible and may help reduce product appeal to nicotine-naïve individuals while maintaining acceptability for smokers.
Tachyonic effects on Kähler moduli stabilized inflaton potential in type-IIB/F theory
Authors: Let Abhijit , Ghosh Buddhadeb 
Published: October 2024

AbstractWe investigate the effects of inclusion of charged tachyonic open-string scalars in the perturbative and the non-perturbative Kähler moduli stabilizations in a geometry of three intersecting magnetized D7-brane stacks in type-IIB/F theory and also study the overall influence of this process on the inflaton potential, in a hybrid inflation scenario. We find that a tachyon lowers the minimum of the inflaton potential and assists to end the inflation. For simplicity, we have included one tachyon at a time in the present work and observe that this procedure preserves the features of slow-roll plateau of the potential. An interesting observation here is that the tachyonic part of the potential can be fine-tuned to get an almost zero minimum of the potential, thereby conforming to the small experimental value of the cosmological constant.
Impact of Q-balls formed by first-order phase transition on sterile neutrino dark matter
Authors: Ma Jiucheng , Jiang Siyu , Li Xiu-Fei 
Published: October 2024

AbstractWe explore the mechanism that can explain the production of lepton asymmetry and two types of sterile neutrino dark matter. The first type involves heavy sterile dark matter produced directly by the decay of Q-balls which are formed by first-order phase transition in the early universe; the second consists of keV sterile neutrino dark matter, produced resonantly with the aid of lepton asymmetry from Q-ball decay. Besides, gravitational waves from cosmic strings generated during the phase transition process could be detected at future interferometers.
Anatomy of vector-like bottom-quark models in the alignment limit of the 2-Higgs doublet model type-II
Authors: Arhrib A. , Benbrik R. , Boukidi M. , Moretti S. 
Published: October 2024

AbstractExpanding upon our ongoing investigation of Vector-Like Quark (VLQ) phenomenology within a 2-Higgs Doublet Model (2HDM) framework, in this paper, we complement a previous one dedicated to Vector-Like Top-quarks (VLTs) by studying Vector-Like Bottom-quarks (VLBs), specifically focusing on their behavior in the alignment limit of a Type-II Yukawa structure. We examine the potential for detecting VLBs at the Large Hadron Collider (LHC) and analyze their decay signatures, encompassing both Standard Model (SM) processes and exotic decays. The objective is to differentiate among singlet, doublet, and triplet configurations of VLBs by identifying distinct decay patterns, thereby providing insights into the structure of Beyond the SM (BSM) physics.
Measurement of the absolute efficiency of the X-ARAPUCA photon detector for the DUNE Far Detector 1
Authors: Álvarez-Garrote R. , Brizzolari C. , Canto A. , Calvo E. , Cattadori C. M. , Cuesta C. , de la Torre Rojo A. , Gil-Botella I. , Gotti C. , Guffanti D. , Machado A. A. , Manthey Corchado S. , Martín I. , Massari C. , Meazza L. , Palomares C. , Pérez-Molina L. , Segreto E. , Terranova F. , Verdugo de Osa A. , Vieira de Souza H. , Warner D. 
Published: October 2024

AbstractThe DUNE far detector has been designed to detect photons and electrons generated by the charged products of the interaction of neutrinos with a massive liquid argon (LAr) target. The photon detection system (PDS) of the first DUNE far detector (FD1) is composed of 6000 photon detection units, named X-ARAPUCA. The detection of the prompt light pulse generated by the particle energy release in LAr will complement and boost the DUNE LAr Time Projection Chamber. It will improve the non-beam events tagging and enable at low energies the trigger and the calorimetry of the supernova neutrinos. The X-ARAPUCA is an assembly of several components. Its photon detection efficiency (PDE) depends on the design of the assembly, on the grade of the individual components and on their coupling. The X-ARAPUCA PDE is one of the leading parameters for the PDS sensitivity, that in turn determines the sensitivity of the DUNE for the detection of core-collapse supernova within the galaxy and for nucleon decay searches. In this work we present the final assessment of the absolute PDE of the FD1 X-ARAPUCA baseline design, measured in two laboratories with independent methods and setups. Preliminary results were reported in Palomares (JINST 18(02):C02064, https://doi.org/10.1088/1748-0221/18/02/C02064, 2023). One hundred sixty units of these X-ARAPUCA devices have been deployed in the NP04 facility at the CERN Neutrino Platform, the 1:20 scale FD1 prototype, and will be operated during the year 2024. The assessed value of the PDE is a key parameter both in the NP04 and in the DUNE analysis and reconstruction studies.
Gravitational orbital Hall effect of vortex light in Lense–Thirring metric
Authors: Qiu Wei-Si , Lian Dan-Dan , Zhang Peng-Ming 
Published: October 2024

AbstractVortex light, characterized by an intrinsic orbital angular momentum aligned with its propagation direction, is described through vortex electromagnetic waves. Similar to the gravitational spin Hall effect (SHE), vortex light is expected to exhibit intrinsic orbital angular momentum dependent trajectories and deviations from the null geodesic plane when propagating through a gravitational field, a phenomenon termed the gravitational orbital Hall effect (OHE). In this work, we model the vortex light as vortex Laguerre–Gaussian electromagnetic wave packets and analyze its motion by solving covariant Maxwell equations within the Lense–Thirring metric. Our findings reveal that the trajectory of vortex light with an intrinsic orbital angular momentum deviates from the null geodesic in two ways. It deviates both perpendicular to, and within, the null geodesic plane. This behavior contrasts with the gravitational SHE, where spin-polarized light primarily deviates perpendicular to the null geodesic plane. Moreover, the relationship between the deviation and intrinsic orbital angular momentum differs significantly from that between the deviation and spin. These results suggest a unique interaction between intrinsic orbital angular momentum and gravity, distinct from the spin-gravity coupling, indicating that the gravitational OHE of light might not be precisely predicted by merely substituting spin with intrinsic orbital angular momentum in the gravitational SHE of light.
Energetics of Buchdahl stars and the magnetic Penrose process
Authors: Shaymatov Sanjar , Dadhich Naresh , Tursunov Arman 
Published: October 2024

AbstractBuchdahl star is the most compact object without an event horizon and is an excellent candidate for a black hole mimicker. Unlike black holes, rotating Buchdahl star can be over-extremal with respect to the black hole, sustaining a larger spin. We show that it can also develop an ergosphere above the threshold spin $$\beta > 1/\sqrt{2}$$

β
>
1
/

2

, which allows extraction of its rotational energy. Electromagnetic field around Buchdahl star is also expected to differ from that of black hole in both strength and topology. In this paper, we explore the energetics of Buchdahl star focusing on the magnetic Penrose process in the two magnetic field configurations, i.e., uniform and dipole. Below the threshold spin, Buchdahl star is expected to be quiet, while above the threshold it can be much more efficient than the black hole if a dipolar magnetic field is developed on its surface.