bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Phthalocyanine‐Based Catalysts in Electrochemical Sensors: A Comprehensive Review
Authors: C P Keshavananda Prabhu , Aralekallu Shambhulinga , Koodlur Sannegowda Lokesh 
Published: October 2024

AbstractMetal phthalocyanines (MPcs) are promising materials for electrochemical sensing due to their physicochemical properties, including redox activity, structural versatility, and chemical stability. These materials can incorporate various metals into their central core, ensuring tunable catalytic activity and enhanced sensitivity and selectivity. This makes MPcs valuable for designing advanced electrochemical sensors, which require precise and reliable performance for applications ranging from environmental monitoring to biomedical diagnostics. This review discusses the advancements in MPc‐based catalysts for electrochemical sensors, focusing on their superior catalytic properties, stability under diverse operating conditions, and high functionalization potential. The unique redox behavior of the metal center in MPcs ensures improved detection capabilities of analytes like biomolecules, heavy metal ions, and environmental pollutants, positioning MPc materials as a cornerstone in future sensor technology. MPc‐based sensors have diverse applications across various fields, including environmental sensing, medical diagnostics, and industrial process monitoring. Recent reports highlight the practical relevance and growing importance of MPcs in real‐world applications. Challenges associated with MPc‐based sensors include scalability, environmental stability, and integration into practical devices. The review concludes with a discussion on the future outlook on MPcs in the design and development of next‐generation electrochemical sensors, paving the way for more efficient, cost‐effective, and reliable detection technologies.
Exploiting β‐Lactams‐Induced Lysis and DNA Fragmentation for Rapid Molecular Antimicrobial Susceptibility Testing of Neisseria Gonorrhoeae via Dual‐Digital PCR
Authors: Hu Jiumei , Chen Liben , Zhang Pengfei , Chen Fan‐En , Li Hui , Hsieh Kuangwen , Li Sixuan , Melendez Johan H. , Wang Tza‐Huei 
Published: October 2024

AbstractThe evolution of antimicrobial resistance (AMR) presents substantial challenges to global medical health systems. Neisseria gonorrhoeae (N. gonorrhoeae), in particular, has developed resistance to all currently available antimicrobials. Addressing this issue necessitates not only discovering new antimicrobials but also deepening the understanding of bacterial responses to these agents, which can lead to new markers for rapid antimicrobial susceptibility testing (AST). Such advancements can enhance treatment outcomes and promote antimicrobial stewardship. In this study, single‐cell techniques, including live‐cell imaging, flow cytometry, and digital polymerase chain reaction (PCR) are utilized, to investigate the lysis dynamics and molecular features of N. gonorrhoeae upon exposure to β‐lactam antimicrobials. Distinct patterns of bacterial lysis and DNA fragmentation are uncovered in susceptible strains. Leveraging these discoveries, a microfluidic dual‐digital PCR approach that combines single‐cell and single‐molecule analyses, facilitate rapid and efficient phenotypic molecular AST for N. gonorrhoeae against β‐lactams is developed. This proof‐of‐concept validation demonstrates the effectiveness of the method in accessing antimicrobial susceptibility across a range of bacterial strains, contributing valuable insights for advancing the battle against AMR.
The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis
Authors: Sun Shumin , Xie Enjun , Xu Shan , Ji Suyu , Wang Shufen , Shen Jie , Wang Rong , Shen Xinyi , Su Yunxing , Song Zijun , Wu Xiaotian , Zhou Jiahui , Cai Zhaoxian , Li Xiaopeng , Zhang Yan , Min Junxia , Wang Fudi 
Published: October 2024

AbstractThe essential trace element, zinc, regulates virtually all aspects of cellular physiology, particularly cell proliferation and survival. Diverse families of metal transporters, metallothioneins, and metal‐responsive transcriptional regulators are linked to zinc homeostasis. However, the mechanism underlying the regulation of systemic zinc homeostasis remains largely unknown. Here, it is reported that the intestinal transporter SLC30A1 plays an essential role in maintaining systemic zinc homeostasis. Using several lines of tissue‐specific knockout mice, it is found that intestinal Slc30a1 plays a critical role in survival. Furthermore, lineage tracing reveals that Slc30a1 is localized to the basolateral membrane of intestinal epithelial cells (IECs). It is also found that Slc30a1 safeguards both intestinal barrier integrity and systemic zinc homeostasis. Finally, an integrative analysis of the cryo‐EM structure and site‐specific mutagenesis of human SLC30A1 are performed and a zinc transport mechanism of SLC30A1 unique within the SLC30A family, with His43 serving as a critical residue for zinc selectivity, is identified.
Biomimetic Electrodynamic Metal‐Organic Framework Nanosponges for Augmented Treatment of Biofilm Infections
Authors: Wang Yanmin , Guo Wei , Zhang Kai , Liu Zhiwen , Dai Xiaoguang , Qiao Zhuangzhuang , Ding Xiaokang , Zhao Nana , Xu Fu‐Jian 
Published: October 2024

AbstractElectrodynamic therapy (EDT) is a promising alternative approach for antibacterial therapy, as reactive oxygen species (ROS) are produced efficiently in response to an electric field without relying on endogenous H2O2 and O2. However, the inherent toxicity of metallic catalysts and numerous bacterial toxins during the therapeutic process still hinder its development. Herein, biomimetic metal–organic (MOF@EV) nanosponges composed of ginger‐derived extracellular vesicles (EVs), and electrodynamic metal–organic frameworks (MOFs) are developed for the eradication of bacterial infections and the absorption of toxins. The prolonged circulation time of MOF@EV in vivo facilitates their accumulation at infection sites. More interestingly, MOF@EV can behave as nanosponges and effectively prevent host cells from binding to bacterial toxins, thereby reducing damage to cells. Subsequently, the MOF@EV nanosponges are discovered to work as electro‐sensitizers, which is confirmed through both theoretical calculation and experimental verification. As a result, ROS is continuously produced under the electric field to achieve effective EDT‐mediated bacterial eradication. Meanwhile, the treatment process of MOF@EV in vivo is visualized in mice infected with luciferase‐expressing Staphylococcus aureus (S. aureus), and excellent biofilm eradication capacity and detoxification efficiency are demonstrated in a subcutaneous abscess model. This work provides a promising strategy for the treatment of bacterial infections.
Soil organic matter characteristics of four soil types under different conservation strategies across Hubei Province
Authors: Yang Wei , He Yangbo , Song Xingsheng , Lin Lirong , Tian Zhengchao , Zhou Ying 
Published: October 2024

AbstractSoil organic matter (SOM) plays key roles in sloping land erosion control. This study explores SOM content across Hubei Province, China, focusing on four soil types under various conservation strategies. Field samples (n = 243) were collected under 27 monitoring sites employing diverse conservation strategies in runoff plots. Results indicated substantial variability in SOM content among soil types, with calcareous soils exhibiting the highest levels (12.63 g kg−1). Conversely, red soils displayed the lowest SOM content (6.32 g kg−1). However, short‐term conservation strategies and their interaction with soil type did not significantly influence SOM. The findings underscore the intricate relationship between soil types and SOM dynamics. This study contributes to the understanding of SOM dynamics in diverse landscapes, offering valuable guidance for policymakers and land managers to apply practices in mitigating erosion and enhancing soil health.Core Ideas
Soil organic matter (SOM) characteristics focusing on four soil types under various conservation strategies were studied in Hubei Province.
Calcareous soils exhibited the highest levels of SOM.
Short‐term conservation strategies have no significant effect on SOM for each soil type.
Land managers need proper practices to retain soil organic matter in mitigating erosion and enhancing soil health.
Catalytic Strategies Enabled Rapid Formation of Homogeneous and Mechanically Robust Inorganic‐Rich Cathode Electrolyte Interface for High‐Rate and High‐Stability Lithium‐Ion Batteries
Authors: Liu Mili , Ying Yiran , Liu Jiangwen , Li Chen , Hu Renzong , Liu Jun , Huang Haitao , Zhang Anwei , Ma Longtao , Ouyang Liuzhang , Zhu Min 
Published: October 2024

AbstractLithium iron phosphate (LFP) cathode is renowned for high thermal stability and safety, making them a popular choice for lithium‐ion batteries. Nevertheless, on one hand, the fast charge/discharge capability is fundamentally constrained by low electrical conductivity and anisotropic nature of sluggish lithium ion (Li+) diffusion. On the other hand, the interface and internal structural degradation occurs when subjected to high‐rate condition. Herein, a multifunctional boron‐doping graphene/lithium carbonate (BG/LCO) nanointerfacial layer on surface of commercial LiFePO4 particles is designed, in which the BG layer catalyzes the rapid reaction of Li2CO3‐LiPF6 for homogeneous and mechanically robust inorganic LiF‐rich structure across the cathode‐electrolyte interphase (CEI), forms a conductive network to significantly enhance both electron and Li+ transport, and strengthens the FeO bonding to minimize both Fe loss and the formation of Fe‐Li antisite defects. Correspondingly, the modified LFP cathode achieves a high capability of 113.2 mAh g−1 at 10 C and extraordinary cyclic stability with 88.0% capacity retention over 1000 cycles as compared to the pristine LFP cathode with a capacity of only 94.0 mAh g−1 and 64.6% capacity retention. It also exhibits great enhancements of 20.1% and 3.7% at higher‐rate condition (room temperature/15 C) and the low temperature condition (−10 °C/1 C), respectively.
Surface Matrix‐Mediated Cation Exchange of Perovskite Quantum Dots for Efficient Solar Cells
Authors: Wang Guoliang , Sun Yuqi , Mei Xinyi , Zhang Mingxu , Qiu Junming , Sun Zhimei , Zhang Xiaoliang 
Published: October 2024

AbstractCesium‐formamidinium lead triiodide perovskite quantum dot (CsxFA1‐xPbI3 PQD) is very promising for photovoltaic applications due to its good phase stability and outstanding optoelectronic properties. However, achieving the CsxFA1‐xPbI3 PQDs with tunable compositions and robust surface matrix remains a challenge. Here, the surface matrix‐mediated cation exchange of PQDs is proposed, in which a bi‐functional molecule, tetrafluoroborate methylammonium (FABF4), is applied for the cation exchange and stabilizing surface matrix of PQDs. The results reveal that the FA+ of FABF4 molecules could exchange the Cs+ of CsPbI3 PQDs forming alloy CsxFA1‐xPbI3 PQDs, allowing to tune the spectroscopies of PQDs. Meanwhile, the BF4− of FABF4 molecules can effectively stabilize the surface lattice and substantially diminish the surface vacancies of PQDs, improving the phase stability and optoelectronic properties of PQDs. Consequently, CsxFA1‐xPbI3 PQD solar cells deliver an efficiency of up to 17.49 %, which is the highest value of CsxFA1‐xPbI3 PQD solar cells. This work provided important design principles for the composition and surface matrix regulation of PQDs for high‐performance solar cells or other optoelectronic devices.
Access to Vinyl Gem‐Difluorinated Cyclopropanes Via Photopromoted Palladium‐Catalyzed Heck Reaction
Authors: Li Bin , Feng Qiu‐Shi , Yuan Jia‐Li , Xia Ying 
Published: October 2024

AbstractA photopromoted Pd‐catalyzed Heck reaction of gem‐difluorocyclopropyl bromides (DFCBs) with styrenes to deliver vinyl gem‐difluorinated cyclopropanes (VDFCs) under mild conditions has been developed. The reaction demonstrates good functional group compatibility while providing high E/Z ratio of the products. Furthermore, the desired VDFCs can be easily transformed into fluorinated cyclic/acyclic architectures, which may broaden its applications in organic synthesis.
Regional differences in autism and intellectual disability risk associated with cesarean section delivery
Authors: Bilder Deborah A. , Sullivan Scott , Hughes Michelle M. , Dalton Susan , Hall‐Lande Jennifer , Nicholls Connor , Bakian Amanda V. 
Published: October 2024

AbstractPrior epidemiological studies investigating the association between delivery mode (i.e., vaginal birth and cesarean section [C‐section]) and autism spectrum disorder (ASD) and intellectual disability (ID) risk have reported mixed findings. This study examined ASD and ID risks associated with primary and repeat C‐section within diverse US regions. During even years 2000–2016, 8‐years‐olds were identified with ASD and/or ID and matched to birth records [ASD only (N = 8566, 83.6% male), ASD + ID (N = 3445, 79.5% male), ID only (N = 6158, 60.8% male)] using the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network methodology. The comparison birth cohort (N = 1,456,914, 51.1% male) comprised all births recorded in the National Center for Health Statistics corresponding to birth years and counties in which surveillance occurred. C‐section rates in the birth cohort demonstrated significant regional variation with lowest rates in the West. Overall models demonstrate increased odds of disability associated with primary and repeat C‐section. Adjusted models, stratified by region, identified significant variability in disability likelihood associated with repeat C‐section: increased odds occurred for all case groups in the Southeast, for ASD only and ID only in the Mid‐Atlantic, and no case groups in the West. Regional variability in disability risk associated with repeat C‐section coincides with differences in birth cohorts' C‐section rates. This suggests increased likelihood of disability is not incurred by the procedure itself, but rather C‐section serves as a proxy for exposures with regional variability that influence fetal development and C‐section rates.
Clinical Outcome of Induction Treatment in the Era of Novel Agents and the Impact of the Number of High‐Risk Cytogenetic Abnormalities (HRA) on Prognosis of Patients With Newly Diagnosed Multiple Myeloma (NDMM): Insights From a Multicenter Study
Authors: Liang Dong , Li Xiaojin , Bai Shenrui , Wang Qiaoli , Zeng Min , Feng Demei , Lu Bo , Li Xiaoqing , Sun Zhiqiang , Li Jianyun , Zhou Huanhuan , Zhang Jialu , Chen Xiaoqin , Xia Zhongjun , Liang Yang , Wang Hua 
Published: October 2024

ABSTRACTBackgroundIn the era of novel agents, the clinical outcomes of induction treatment and the impact of the number of high‐risk cytogenetic abnormalities (HRA) in newly diagnosed multiple myeloma (NDMM) need to be explored.ObjectiveThrough this study, we aim to analyze the effectiveness of different induction treatments and explore the survival outcomes of patients with varying numbers of HRA.MethodsA total of 734 patients from seven medical centers were included in our study.ResultsPatients in the CD38 monoclonal antibody or IMiDs plus proteasome inhibitors (PI) groups had significantly superior overall survival (OS) and progression‐free survival (PFS) compared to those receiving IMiDs or PI alone. Additionally, the CD38 monoclonal antibody conferred a PFS advantage over IMiDs plus PI. Patients with ≥ 2 high‐risk cytogenetic abnormalities (HRA) exhibited an extremely poor prognosis and should be considered ultra‐high‐risk individuals in multiple myeloma (MM). The CD38 monoclonal antibody, transplantation, and achieving minimal residual disease (MRD) negativity only partly mitigated the poor prognosis in patients with HRA. Furthermore, patients with 1q21 gain/amplification (1q21+) only had a significantly worse prognosis compared to patients without HRA, and those with 1q21+ plus del17p or t(4;14) exhibited an inferior prognosis compared to those with 1q21+ alone.ConclusionOur results suggested that double‐hit multiple myeloma was associated with extremely poor survival outcomes, and more effective treatments needed to be explored for this particular subtype of MM.
Exploring Teucrium Aureo‐Candidum Essential Oil as a Promising Alternative to Triclosan for Targeting Enoyl‐Acyl Carrier Protein Reductase: Chemical Composition, Antibacterial Activity, and Molecular Docking Study
Authors: Sara Yahla , Belkacem Gordo , Nadia Aissaoui , Kamel Msaada , Omar Messaoudi , Mohammed Gherib , Abdel Ilah Amrouche 
Published: October 2024

AbstractThe chemical composition of the essential oil isolated from the aerial parts of Teucrium aureo‐candidum, an endemic aromatic shrub collected from Moghrar and Djeniene Bourezg in the Nâama region (Algeria), was determined for the first time using GC/FID and GC/MS. A total of 45 constituents were identified, representing 87.73 % of the oil. Characterized by unique chemical variability, it was primarily composed of sesquiterpene hydrocarbons (29.53 %) and oxygenated sesquiterpenes (30.06 %), with the major compounds being γ‐cadinene (5.24 %), δ‐cadinene (4.24 %), α‐muurolene (4.04 %), τ‐muurolol (11.35 %), and α‐cadinol (3.30 %). However, monoterpene hydrocarbons and oxygenated monoterpenes accounted for 23.98 % and 1.64 %, respectively, contributing to a relatively low fraction. The essential oil demonstrated notable antibacterial activity, particularly against Gram‐positive bacteria. Due to safety concerns associated with triclosan, a known inhibitor of the Enoyl‐Acyl Carrier Protein Reductase (FabI) enzyme, the essential oil components from this plant were explored as alternatives through a combination of experimental approaches and in silico molecular docking studies. The results revealed that α‐cadinol, spathulenol, caryophyllene, and α‐muurolene exhibited strong FabI inhibition, with better bioavailability and lower toxicity than triclosan, highlighting their potential in combating antibiotic‐resistant bacteria.
Designing Artificial Laccase Catalysts by Introducing Substrate Oxidation Metals into Oxygen‐Reducing Metal‐Organic Frameworks: Cu‐Doped ZIF‐67
Authors: Nakahara Hiroki , Hitomi Yutaka 
Published: October 2024

AbstractLaccase, a multi‐copper oxidase, is limited by its optimal temperature range and isolation costs. To overcome these challenges, we synthesized copper‐doped zeolitic imidazolate framework‐67 (Cu‐doped ZIF‐67) with 16 mol % Cu as an artificial laccase catalyst. The introduced Cu site acts as the phenol oxidation site, and Co‐based ZIF‐67 is the four‐electron oxygen reduction site. Laccase also employs this division of oxidation and reduction sites. Cu‐doped ZIF‐67 demonstrated significant catalytic activity, superior to natural laccase, especially at elevated temperatures, and maintained stability across multiple reaction cycles. These findings suggest that Cu‐doped ZIF‐67 is a robust, reusable alternative for industrial applications requiring high thermal stability and efficient catalysis.
Widening the Stimuli‐Responsiveness of Aqueous Biphasic Systems by Changing the Ionic Liquid Cation Basicity
Authors: Rufino Ana F. C. S. , Capela Emanuel V. , Quental Maria V. , Coutinho João A. P. , Vraneš Milan B. , Gadžurić Slobodan B. , e Silva Francisca A. , Freire Mara G. 
Published: October 2024

AbstractHerein we demonstrate the formation of new stimuli‐responsive aqueous biphasic systems (ABS), able to respond simultaneously to temperature and pH, or just to one stimulus, therefore allowing the design of more sustainable separation processes. This dual behavior is achieved with ABS formed by mono‐ or dicationic protic ionic liquids as phase‐forming components, being defined by the ionic liquid cation chemical structure or its basicity. While ABS comprising monocationic ionic liquids only respond to the effect of temperature, systems comprising dicationic ionic liquids are simultaneously affected by both temperature and pH variations. Dicationic ionic liquids are here identified as the key to unlock a double response to stimuli, which is due to the presence of two pKa values afforded by the cation. The reported findings contribute to increase the customizability of double stimuli‐responsive ABS based on ionic liquids, whose development was up to date limited to ionic liquids bearing pH‐responsive anions, opening the door towards the development of more sustainable separation processes.
Enabling Access to 3‐gem‐Difluorovinyl Lactams via Zn‐Mediated Sequential Single Electron Reductive Hydrodehalogenation
Authors: Zheng Jia , Liu Xuran , Yin Jiawen , Li Shuaikang , Zhang Juanjuan , Hu Weigao 
Published: October 2024

Comprehensive SummaryHerein, we describe a direct route for the synthesis of 3‐gem‐difluorovinyl lactams through Zn‐mediated reductive hydrodehalogenation. Importantly, by using inexpensive deuterium oxide (D2O), the high value‐added vicinal dideuterated gem‐difluoroalkenes with excellent deuterium (D) incorporation were prepared. Mechanism studies indicated a successive single electron transfer process: the reaction initially undergoes hydrodechlorination to give the intermediate α‐trifluoromethylidene lactams, which are then activated by the in‐situ generated zinc cations and reduced to the desired product via hydrodefluorination.
Fluorescent “On‐Off‐On” Probe for Cascade Detection of Ag(I) and Ascorbic Acid Using Folic Acid Protected Copper Nanoclusters
Authors: Vegad Yagnik , Rana Lata , Ranjan Jali Bigyan , Sahoo Suban K. 
Published: October 2024

AbstractFolic acid (FA) protected copper nanoclusters (FA‐CuNCs, λex=350 nm, λem=445 nm) were synthesized and used as a fluorescent “on‐off‐on” probe for the cascade detection of Ag+ and ascorbic acid (AA). The fluorescence emission of FA‐CuNCs at 445 nm was quenched significantly by Ag+ due to the analyte‐induced aggregation followed by the formation of larger nanoparticles. However, when AA was added to the in‐situ generated Ag@FA‐CuNCs, the fluorescence emission of FA‐CuNCs was recovered at 445 nm because of the AA‐directed reduction of Ag+ to Ag0. The experimental conditions, such as pH, incubation time, and quencher Ag+ concentrations, were optimized to achieve improved sensitivity. The detection limit for Ag+ and AA was estimated as 37.1 nM and 0.27 μM with a linearity range of 2.49–22 μM and 4.71–81.53 μM, respectively. In real sample analysis, the recoveries of Ag+ ions in river water and AA in orange juice samples were found between 99–93 % and 97–94 % using the probes FA‐CuNCs and Ag@FA‐CuNCs, respectively. Overall, this work offers a viable method for the sequential detection of Ag+ and AA using FA‐CuNCs via a fluorescence “on‐off‐on” switch mechanism.