bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of a thyroid carcinoma cell line derived from spinal metastasis
Authors: Zhou Zhenhua , Li Yan , Yan Xu , Wang Xudong , Chen Su , Xiao Jianru 
Published: November 2016

A thyroid carcinoma cell line named THY28 was established through primary culture of the surgical specimens, which were derived from a Chinese patient with spinal metastasis. The cell morphology, growth kinetics, cell cycle, chromosome number, cell capability of migration, tumorigenicity and cytogenetic features of the cell line were investigated. THY28 cells were subcultured in vitro for more than 50 passages with a human karyotype. The modal number of its chromosomes was mainly from 67 to 85. The doubling time of THY28 cells was 56 hours. The histopathological features of xenograft induced by THY28 cells were consistent with the characteristics of thyroid cancer. The biological and molecular properties of THY28 cells were not entirely consistent with those of other thyroid carcinoma cells such as SW579 and TT cells, indicating biological differences between primary and metastatic thyroid carcinoma cell lines. We have established a novel thyroid carcinoma cell line derived from spinal metastasis, which will provide a useful model for biological or therapeutic studies of thyroid carcinoma metastasis.
Improving Mobile Phone Speech Recognition by Personalized Amplification: Application in People with Normal Hearing and Mild-to-Moderate Hearing Loss
Authors: Kam Anna Chi Shan , Sung John Ka Keung , Lee Tan , Wong Terence Ka Cheong , van Hasselt Andrew 
Published: November 2016

Purpose:
In this study, the authors evaluated the effect of personalized amplification on mobile phone speech recognition in people with and without hearing loss.

Methods:
This prospective study used double-blind, within-subjects, repeated measures, controlled trials to evaluate the effectiveness of applying personalized amplification based on the hearing level captured on the mobile device. The personalized amplification settings were created using modified one-third gain targets. The participants in this study included 100 adults of age between 20 and 78 years (60 with age-adjusted normal hearing and 40 with hearing loss). The performance of the participants with personalized amplification and standard settings was compared using both subjective and speech-perception measures. Speech recognition was measured in quiet and in noise using Cantonese disyllabic words. Subjective ratings on the quality, clarity, and comfortableness of the mobile signals were measured with an 11-point visual analog scale. Subjective preferences of the settings were also obtained by a paired-comparison procedure.

Results:
The personalized amplification application provided better speech recognition via the mobile phone both in quiet and in noise for people with hearing impairment (improved 8 to 10%) and people with normal hearing (improved 1 to 4%). The improvement in speech recognition was significantly better for people with hearing impairment. When the average device output level was matched, more participants preferred to have the individualized gain than not to have it.

Conclusions:
The personalized amplification application has the potential to improve speech recognition for people with mild-to-moderate hearing loss, as well as people with normal hearing, in particular when listening in noisy environments.
Comparison of Sleep Latency and Number of SOREMPs in the Home and Hospital With a Modified Multiple Sleep Latency Test: A Randomized Crossover Study
Authors: Beiske Kornelia K. , Sand Trond , Rugland Eyvind , Stavem Knut 
Published: November 2016

Purpose:
Comparison of mean sleep latencies and number of sleep-onset rapid eye movement periods (SOREMPs) between modified multiple sleep latency test (MSLT) performed in the unattended home and in-hospital laboratory setting.

Methods:
A randomized crossover single-blinded design. Thirty-four subjects referred to MSLT for suspected hypersomnia or narcolepsy were included. Participants were randomized to perform modified MSLT in the unattended home or in the hospital first. Scores in the two settings were compared using Wilcoxon signed-rank test or exact McNemar test. Agreement between home and hospital categorized mean sleep latency and number of SOREMPs was assessed using simple kappa (κ) and proportion agreement. Agreement between home and hospital mean sleep latency was assessed using a Bland–Altman plot and an intraclass correlation coefficient.

Results:
There was no difference between home and hospital assessment of mean sleep latency (P = 0.86). Two or more SOREMPs were found more frequently on modified MSLTs performed at home compared with those at the hospital (7 and 2, respectively; P = 0.025). Agreement was moderate for categorized sleep latency (κ = 0.53) and fair for categorized SOREMPs (κ = 0.39) in the 2 settings. Analysis of mean sleep latency using intraclass correlation coefficient showed a very good agreement between the two settings.

Conclusions:
Group mean sleep latency for home modified MSLTs seems to be reliable compared with that for the attended sleep-laboratory setting. Higher rate of SOREMP in the unattended home suggests that napping in a familiar environment facilitates the transition into REM sleep. Further studies are needed to assess the normal limit, sensitivity, and specificity for SOREMP at home before the clinical utility of home-based napping can be determined.
Non-fragile robust H∞ control of nonlinear networked control systems with time-varying delay and unknown actuator failures
Authors: Zhi Yueming , Jiang Shun , Pan Feng 
Published: November 2016

Purpose
This paper is concerned with non-fragile robust H∞ control problems for nonlinear networked control systems (NCSs) with time-varying delay and unknown actuator failures. The paper aims to discuss these issues.

Design/methodology/approach
The system parameters are allowed to have time-varying uncertainties and the actuator faults are unknown but whose upper and lower bounds are known. By using some lemmas, uncertainties can be replaces with the known values. By taking the exogenous disturbance and network transmission delay into consideration, a delay nonlinear system model is constructed.

Findings
Based on Lyapunov stability theory, linear matrix inequalities (LMIs) and free weighting matrix methods, the sufficient conditions for the existence of the non-fragile robust H∞ controller gain are derived and which can obtained by solving the LMIs. Finally, a numerical example is provided to illustrate the effectiveness of the proposed methods.

Originality/value
The introduced approach is interesting for NCSs with time-varying delay and unknown actuator failures.
Aerial vehicle guidance based on passive machine learning technique
Authors: Chithapuram Chethan Upendra , Cherukuri Aswani Kumar , Jeppu Yogananda V. 
Published: November 2016

Purpose
The purpose of this paper is to develop a new guidance scheme for aerial vehicles based on artificial intelligence. The new guidance scheme must be able to intercept maneuvering targets with higher probability and precision compared to existing algorithms.

Design/methodology/approach
A simulation setup of the aerial vehicle guidance problem is developed. A model-based machine learning technique known as Q-learning is used to develop a new guidance scheme. Several simulation experiments are conducted to train the new guidance scheme. Orthogonal arrays are used to define the training experiments to achieve faster convergence. A well-known guidance scheme known as proportional navigation guidance (PNG) is used as a base model for training. The new guidance scheme is compared for performance against standard guidance schemes like PNG and augmented proportional navigation guidance schemes in presence of sensor noise and computational delays.

Findings
A new guidance scheme for aerial vehicles is developed using Q-learning technique. This new guidance scheme has better miss distances and probability of intercept compared to standard guidance schemes.

Research limitations/implications
The research uses simulation models to develop the new guidance scheme. The new guidance scheme is also evaluated in the simulation environment. The new guidance scheme performs better than standard existing guidance schemes.

Practical implications
The new guidance scheme can be used in various aerial guidance applications to reach a dynamically moving target in three-dimensional space.

Originality/value
The research paper proposes a completely new guidance scheme based on Q-learning whose performance is better than standard guidance schemes.
A culture of peace and leadership education
Authors: Schellhammer Erich P. 
Published: November 2016

PurposeThe purpose of this paper is to explore the connections between the principles of a culture of peace and leadership education. It argues that leadership should be informed by the values of a culture of peace. This, in turn, compels leadership education to teach mindsets, values and competencies aligned with a culture of peace.Design/methodology/approachThe paper explores the evolution of leadership theory within the context of an increasingly complex world. It then uses United Nations materials to identify principles for a culture of peace as it is now widely acknowledged by the world community. Identifying correspondence between both theoretical realms the paper identifies peace leadership education goals that are supported by established peace organizations and by philosophical and psychological scholarship.FindingsThe paper establishes a direct link between the values of a culture of peace and leadership that is adequate as well as successful to address the complexity of today’s world. It also identifies key principles that need to be adopted by leadership education to prepare students to become effective leaders. The paper also explores essential educational tools for leadership educators.Practical implicationsThe theoretical framework presented in this paper can be used to adjust leadership education to give practical guidance for aspiring leaders. It is also useful for peace and conflict studies programmes interested in developing peace leaders.Originality/valueThe interrelationship between leadership studies and peace and conflict studies constitutes a new field of academic inquiry. The present paper is one of the first in the field and is intended to further establish this new disciplinary orientation.
New developments in peace leadership
Authors: Ricke-Kiely Theresa 
Published: November 2016

PurposeThe purpose of this paper is to provide a viewpoint on leadership development in the conflict transformation and peacebuilding fields, highlighting a need for the inclusion of some new topics to address contemporary leadership concerns.Design/methodology/approachThe author provides experiential reflections on developing global leaders in the peacebuilding field.FindingsThis paper illustrates the importance of developing peacebuilders, currently used methods, and describes prospective topics that may enhance learning and effectiveness.Practical implicationsThis paper offers suggestions for academics and practitioners on new ways of teaching leadership development to those professionals in the field of peacebuilding.Originality/valueThe author describes challenges and opportunities in leadership development for peace professionals in a global context.
Internal auditor characteristics, internal audit effectiveness, and moderating effect of senior management
Authors: Endaya Khaled Ali , Hanefah Mustafa Mohd 
Published: November 2016

Purpose
The purpose of this paper is to investigate the direct relationship between internal auditor’s characteristics[1] and internal audit effectiveness[2], and the moderating effect of senior management[3] support.

Design/methodology/approach
Standard multiple regression and moderated multiple regression are applied, and the data were collected from 114 members of Libyan Association of Accountants and Auditors[4] by using personally administered questionnaire.

Findings
The findings reveal that internal auditor’s characteristics have a significant impact on internal audit effectiveness, and senior management support has a moderating effect.

Practical implications
The findings would encourage Libyan organizations to concentrate on the issue of internal audit effectiveness, and will strengthen the capacity of internal auditing in public organizations.

Originality/value
This paper contributes to the literature of both internal audit and management studies and represents the first effort to examine the impact of internal auditor’s characteristics on internal audit effectiveness with senior management support as a moderating variable.
Measuring unobservable factors in residential developments: a structural equation approach
Authors: Lundgren Berndt Allan , Wallentin Fan Yang 
Published: November 2016

Purpose
The purpose of this paper is to investigate how to measure the effect of unobservable factors on residential choice behaviour in an attempt to advance the understanding of how to perform advanced market analysis. This research is important to residential developers, as the diversity of preferences is increasingly driven by lifestyle-based households and affluent households.

Design/methodology/approach
Information about the pros and cons of renting an apartment in an ongoing residential development project in Stockholm came from interviews using the laddering technique. Qualitative data were subsequently analysed using exploratory and confirmatory factor analysis to confirm which factors had the highest effect on an overall assessment of living in the development and a value-for-money conclusion.

Findings
Among the potentially important factors identified, respondents who became residents perceived the development to be more noise-free than those who did not when stating the overall value of living in the development and making a value-for-money conclusion. The perception of noise differed between the two groups, meaning that those who did not become residents believed the development to be more exposed to noise. The standard of the apartment was the second most influential factor when stating the overall value of living in the development and making a value-for-money conclusion. The belief of being able to relax in the home environment had no significant effect on overall value for either group.

Originality/value
The results show that confirmatory factor analysis can be used in measuring the effect of unobservable factors in residential choice behaviour. The methodology presented may advise developers, architects or planners in evaluating those attributes that create value-for-money to improve, for example, overall design solutions in urban development projects.
Home-to-work spillover and employability among university employees
Authors: Veld Monique , van der Heijden Béatrice I.J.M. , Semeijn Judith H. 
Published: November 2016

Purpose
The purpose of this paper is to investigate the relationship between positive and negative home-to-work spillover, i.e., home-to-work facilitation (HWF) and home-to-work conflict (HWC) with employability. Moreover, this study also examined whether the relationship between home-to-work spillover and employability varied between academic and support staff employees.

Design/methodology/approach
An on-line self-report questionnaire was distributed among academic (n=139) and support staff employees (n=215) working at a Dutch university for distance-learning education. Thoroughly validated measures of home-to-work spillover and employability were used. The employability measure consisted of five dimensions: occupational expertise, anticipation and optimization, personal flexibility, corporate sense, and balance. Hypotheses were tested using hierarchical multivariate regression analyses including interaction effects.

Findings
HWF was positively related to anticipation and optimization only, while HWC appeared to be negatively associated with all employability dimensions. As expected, the relationships between HWF and HWC on the one hand and the specific employability dimensions on the other hand were stronger for support staff employees than for academic staff employees.

Originality/value
This study has extended research on employability, by focusing on the home context of employees as a possible antecedent. So far, studies have largely ignored the home context of employees, when investigating employability outcomes. Another contribution was the focus on both positive (facilitation) and negative (conflict) spillover from home-to-work, whereas previous studies mainly focused on one type of spillover only. Finally, the authors had the unique opportunity to compare support staff and academic staff employees in one and the same study.
Recognition of side effects as implicit-opinion words in drug reviews
Authors: Ebrahimi Monireh , Yazdavar Amir Hossein , Salim Naomie , Eltyeb Safaa 
Published: November 2016

Purpose
Many opinion-mining systems and tools have been developed to provide users with the attitudes of people toward entities and their attributes or the overall polarities of documents. In addition, side effects are one of the critical measures used to evaluate a patient’s opinion for a particular drug. However, side effect recognition is a challenging task, since side effects coincide with disease symptoms lexically and syntactically. The purpose of this paper is to extract drug side effects from drug reviews as an integral implicit-opinion words.

Design/methodology/approach
This paper proposes a detection algorithm to a medical-opinion-mining system using rule-based and support vector machines (SVM) algorithms. A corpus from 225 drug reviews was manually annotated by a medical expert for training and testing.

Findings
The results show that SVM significantly outperforms a rule-based algorithm. However, the results of both algorithms are encouraging and a good foundation for future research. Obviating the limitations and exploiting combined approaches would improve the results.

Practical implications
An automatic extraction for adverse drug effects information from online text can help regulatory authorities in rapid information screening and extraction instead of manual inspection and contributes to the acceleration of medical decision support and safety alert generation.

Originality/value
The results of this study can help database curators in compiling adverse drug effects databases and researchers to digest the huge amount of textual online information which is growing rapidly.
Tweets speak louder than leaders and masses
Authors: Gul Sumeer , Mahajan Iram , Nisa Nahida Tun , Shah Tariq Ahmad , Asifa Jan , Ahmad Suhail 
Published: November 2016

Purpose
Twitter as a social tool allows people to express their views, emotions or communicate information within brevity of 140 character limit. It has provided an opportunity to researchers to tab users’ expressions on social or political issues, be it natural calamity, elections and alike. The purpose of this paper is to assess how people explored Twitter to express their views regarding state assembly elections of Jammu and Kashmir (India).

Design/methodology/approach
The authors performed content analysis of 4,537 tweets that were posted by 1,420 different Twitter users over a period of 78 days (October 30, 2014 through January 15, 2015).

Findings
Users were found to be active on the days of polling while post-polling period witnessed a huge influx in particular on the day of voting and declaration of results. Nearly 94 percent users have posted around 50 percent of tweets and there were only 81 handles which posted remaining 50 percent tweets. In additions to people, news agencies, anonymous groups and social/political groups have expressed their views on this event. Nearly one-fourth tweets were retweeted and one-fourth tweets were marked favorite. Users have mostly providing news updates or personnel commentaries about the election process.

Originality/value
The study is first of its kind using Twitter to represent the sentiments of people during floods.
Generalized multinucleate cell angiohistiocytoma: case report and literature review
Authors: Wang Ming , Abdul‐fattah Bilal , Wang Cuiyan , Zhao Yun , Qu Xiaoying , Al‐Muriesh Maher , Wang Xia , Zhu Li , Qian Yue , Huang Changzheng , Chen Siyuan 
Published: November 2016

BackgroundMultinucleate cell angiohistiocytoma (MCAH) is an uncommon benign fibrohistiocytic and vascular proliferation, which usually occurs as slow‐growing grouped reddish‐brown to purple papules and nodules on the distal extremities or face. Patients with generalized MCAH are extremely rare and to our knowledge, there are no more than 11 cases reported previously in the medical literature.ObjectiveTo describe the clinical, histopathologic features and immunohistochemical characteristics of all reported cases of generalized MCAH and investigate any potential clinicopathological correlations.MethodsA systematic review of the literature was done with information collected and organized in a table. A new case report is also described in a 42‐year‐old female with generalized MCAH. Histopathologic and immunohistochemical features of multiple biopsies were analyzed.ResultsMen and women are equally affected. It is crucial to take multiple biopsies preferably from newly formed lesions to reach the correct diagnosis. The divergent results in immunohistochemistry staining for CD68 and estrogen receptor (ER) alpha necessitate further studies to reach a precise etiology and pathogenesis and secure it with certainty.ConclusionAwareness of the clinicopathological hallmarks is important to avoid underdiagnosis of MCAH and the immunohistochemical features may contribute to understanding the pathogenesis of this rare disease.
Interspecific variation in neighbour–stranger discrimination in ants of theNeoponera apicaliscomplex
Authors: YAGOUND BORIS , CROWET MATHILDE , LEROY CHLOÉ , POTEAUX CHANTAL , CH ÂLINE NICOLAS 
Published: November 2016

1. The ecological success of social insects lies in their ability to prevent the exploitation of colony resources by competitors or parasites. Nestmate recognition is therefore of crucial importance in maintaining the integrity of the colony. Furthermore, inter‐colony competitive relationships are often complex, as many species discriminate between neighbours and strangers, with reduced (the dear enemy phenomenon) or increased levels of aggression towards nearby colonies, depending on the species. In this context, between‐species comparisons could be particularly helpful to investigate the proximate causes underlying this context‐dependent phenomenon, but these are notoriously lacking.2. Here an attempt was made to circumvent this drawback by studying three closely related sympatric ant species with very similar life histories that belong to theNeoponera apicaliscomplex. The present study investigated how nestmate recognition and inter‐colony competitive relationships were influenced by spatial, chemical and genetic distances between colonies.3. It was found that one species,N. apicalismorph 7, showed a clear dear enemy phenomenon with no influence of chemical and genetic distances, suggesting the existence of a learning process. In contrast,N. apicalismorph 4 andNeoponera verenaemorph 1 failed to show any strong discrimination between close and distant non‐nestmates.4. These results are discussed in the light of the observed interspecific variation in nesting preferences, possibly constraining the opportunities of familiarisation between nearby nests, and modulating the competition for resources between colonies.5. It is argued that this study further reinforces the relative threat level hypothesis as an ultimate explanation for neighbour–stranger discrimination processes.