bluuebunny/crossref_metadata_2025_split huggingface dataset:
Імпресіонізм в поезії Любові Долик
Authors: Korenowska Lesława 
Published: October 2024

У статті подано аналіз віршів сучасної львівської поетеси Любові Долик в інтегральному аспекті: поетичне слово та живопис, а точніше імпресіонізм. Автор насвітлює генезис імпресіонізму, називає його найважливіші риси та ілюструє проникнення цього напряму живопису в художню літературу: вірші таких поетів, як Шарль Бодлер, Осип Мандельштам, проза українських письменників (Іван Франко, Михайло Коцюбинський, Ольга Кобилянська). Вірші двох поетичних збірок Ліки від хаосу та Щастя Долик — це здебільшого ліричні пейзажі, зображені, як на картинах художників-імпресіоністів: зима з акцентом на улюблений мотив поетеси — сніг, весняні етюди, дощова погода. Долик в дескрипціях природи використовує конкретні кольори — чорний і білий із сірим посередині, рожевий, сливовий, жовтий і золотий, — які створюють візуальний контраст. Компоненти зовнішнього світу, що потрапляють у зорове поле поетеси, часто переплітаються із психологічним станом настрою, почуттями, думками, мріями, враженнями Долик.
Образ війні в площині пубілчної історії: на прикладі відео українських та російських YouTube каналів
Authors: Dudar Olga 
Published: October 2024

На онлайн-платформі YouTube представлено безліч відео на історичну тематику. Зі зростанням популярності такого контенту, у з'являється все більше блогерів, які не створюють власний незалежний продукт, а поширюють певніні політічні наратави. В умовах російсько-української війни історичний контент стає інструментом поширення не тільки фактичної інформації, а й політичних ідей та джерелом трансформації колективної пам’яті. Репрезентоване дослідження виявляє впливи “культу Перемоги” як у відео провладних блогерів з Російської Федерації, так і певні радянські наративи у творчості блогерів опозиційних. Оскільки україномовний сегмент YouTube перебуває у стані розвитку, частина блогерів проширює міфи, які формують негативний образ Радянського Союзу. Але досить просто знайти такий інформаційний продукт українських авторів, який є достовірним, виваженим і ґрунтується сучасних історичних дослідженнях.
Штрихи до історії повсякдення Німеччини доби Третього рейху: на матеріалах соціологічного опитування за 1934 р.
Authors: Давлєтов Oлександр , Саламаха Ігор 
Published: October 2024

У статті здійснено аналіз автобіографій «бойової доби» НСДАП, що дозволило показати основні мотиваційні вектори «партайгеноссе» фюрера – знайти відповідь на питання чим саме привернув їх увагу нацизм у 20 - ті – на початку 30-х рр. ХХ ст. Також, проаналізовано багато вцілілих конкурсних робіт, завдяки чому було виділено основний мотив, який вплинув на електоральний партійний вибір людей за доби існування Веймарської Республіки (1919-1933 рр.). Це привело до легального прориву нацистів до влади. Наразі, можна зазначити, що монографія Т.Абеля та першоджерела із зібрання американської бібліотеки Герберта Гувера є чудовим джерелом з доби існування і Третього рейху, і Веймарської Республіки. Праворадикальна мотивація багатьох ранніх членів нацистської партії добре узгоджується зі станом невдоволеності сучасною політичною ситуацією, що поширена і у Європі ХХI століття.
Multiple relocation cases in disaster-related deaths after the Fukushima nuclear accident
Authors: Ito Naomi , Sawano Toyoaki , Uchi Yuna , Kawashima Moe , Kitazawa Kemmei , Moriyama Nobuaki , Amir Isamu , Yoshimura Hiroki , Nonaka Saori , Saito Hiroaki , Ozaki Akihiko , Yamamoto Chika , Abe Toshiki , Murakami Michio , Sato Mika , Matsumoto Chihiro , Yamamura Momoka , Zhao Tianchen , Sakakibara Mamoru , Yagiuchi Kazuko , Otsuki Mako , Oikawa Tomoyoshi , Niwa Shinichi , Tsubokura Masaharu 
Published: October 2024

IntroductionRelocation after a disaster often has negative health effects on vulnerable people, particularly older adults. However, little is known about the number of repeated evacuations and relocations after disasters among those experienced disaster-related deaths. This case series aimed to summarize the secondary problems and mortality risks in patients involved in relocation after disasters.MethodsWe analyzed and summarized the data on 520 disaster-related deaths in Minamisoma City, a municipality near the Fukushima Daiichi Nuclear Power Plant, focusing on the number of relocations. Herein, we describe the cases of three individuals over 80 years old, who died after eight or more relocations, which were certified as disaster-related deaths.ResultsWe discuss following three cases, which are (1) a female patient in her 90s who had a stroke and was completely disabled, (2) a female patient in her 80s whose cancer was detected later due to her failing to see her family doctor, and (3) a male patient in his 80s whose regular postoperative treatment was disrupted following cancer recurrence.DiscussionOur findings indicate that evacuation led to the worsening of chronic diseases and eventually to post-disaster death. Prolonged wide-area evacuation and repeated relocation likely interrupted the continuum of care and led to the failure of adequate care provision. To reduce the loss of human life, it is necessary to review the number of wide-area evacuations and relocations over the medium to long term after large-scale disasters, including nuclear disasters, which may occur in the future. Simultaneously, it is important to establish a medical system at the evacuation site so that disaster victims can continue to receive medical care even after evacuation or relocation.
Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model
Authors: Hao Xia , Reyes Palomares Arturo , Anastácio Amandine , Liu Kui , Rodriguez-Wallberg Kenny A. 
Published: October 2024

IntroductionThe mechanisms leading to ovarian primordial follicle depletion following gonadotoxic chemotherapy with cyclophosphamide and other cytotoxic drugs are currently understood through two main explanatory theories: apoptosis and over-activation. Discrepancies between the findings of different studies investigating these mechanisms do not allow to reach a firm conclusion. The heterogeneity of cell types in ovaries and their different degrees of sensitivity to damage, cell-cell interactions, periodical follicle profile differences, model age-dependent differences, and differences of exposure durations of tested drugs may partially explain the discrepancies among studies.MethodsThis study used intact prepubertal mice ovaries in culture as study model, in which most follicles are primordial follicles. Histological and transcriptional analyses of ovaries exposed to the active metabolite of cyclophosphamide 4-hydroperoxycyclophosphamide (4-HC) were carried out via a time-course experiment at 8, 24, 48, and 72 h.Results4-HC treated ovaries showed a significant decrease in primordial follicle density at 24 h, along with active DNA damage (TUNEL) and overexpressed apoptosis signals (cleaved-poly ADP ribose polymerase in immunohistochemistry and western blotting). Meanwhile 4-HC treatment significantly up-regulated H2ax, Casp 6, Casp 8, Noxa, and Bax in ovaries, and up-regulated Puma in primordial follicles (FISH).DiscussionOur results indicated that cyclophosphamide-induced acute ovarian primordial follicle depletion was mainly related to apoptotic pathways. No evidence of follicle activation was found, neither through changes in the expression of related genes to follicle activation nor in the density of growing follicles. Further validation at protein level in 4-HC-treated prepubertal mice ovaries at 24 h confirmed these observations.
Diagnostic accuracy of a non-invasive spot-check hemoglobin meter, Masimo Rad-67® pulse CO-Oximeter®, in detection of anemia in antenatal care settings in Kenya
Authors: Koech Angela , Mwaniki Isaac , Mutunga Joseph , Mukhanya Moses , Mwadime Emily , Ochieng Marvine , Mwashigadi Grace , Mistry Hiten D. , Craik Rachel , von Dadelszen Peter , Temmerman Marleen , Luchters Stanley , Omuse Geoffrey ,   The PRECISE Network
Published: October 2024

BackgroundPoint of care hemoglobin meters play key roles in increasing access to anemia screening in antenatal care especially in settings with limited access to laboratories. We aimed to determine the diagnostic accuracy of a non-invasive spot-check hemoglobin (SpHb) meter, Masimo Rad-67® Pulse CO-Oximeter®, in the diagnosis of anemia in pregnant women attending antenatal care clinics in Kilifi, Kenya.MethodsThis was a diagnostic accuracy study that retrospectively evaluated SpHb against a validated reference standard of laboratory assessed hemoglobin (Lab Hb) by a SYSMEX XN-330 automated hematology analyzer. The study was nested within a prospective pregnancy cohort study that recruited unselected pregnant women from antenatal care clinics in two public hospitals in Kilifi County, coastal Kenya. Records with both SpHb and Lab Hb were selected from pregnancy visits between May 2021 and December 2022. Linear regression and Bland-Altman analysis were performed to compare the two tests and diagnostic accuracy parameters obtained for the diagnosis of anemia.ResultsA total of 2,975 records (from 2,203 unique participants), with paired SpHb and Lab Hb were analyzed. Linear regression showed a significant but weak positive correlation, a proportional bias of 0.44 (95% CI 0.41–0.47) and a constant of 7.59 (95% CI 7.30–7.87, p &lt; 0.001). The median bias was 1.70 g/dl, with limits of agreement of −0.80 to 4.20. SpHb tended to be higher than Lab Hb on the low hemoglobin range but lower than Lab Hb on the high hemoglobin range. The sensitivity of SpHb in detecting anemia was 18.66%. Prevalence, specificity, positive predictive value, and negative predictive values were 46.37%, 96.77%, 83.33%, and 57.92% respectively.ConclusionOverall, SpHb by Masimo Rad-67® Pulse CO-Oximeter® did not accurately identify pregnant women with anemia and many cases would be missed. We would not recommend its use in antenatal care settings.
Surviving septic patients endotyped with a functional assay demonstrate active immune responses
Authors: Price Adam D. , Becker Ellen R. , Barrios Evan L. , Mazer Monty B. , McGonagill Patrick W. , Bergmann Christian B. , Goodman Michael D. , Gould Robert W. , Rao Mahil , Polcz Valerie E. , Kucaba Tamara A. , Walton Andrew H. , Miles Sydney , Xu Julie , Liang Muxuan , Loftus Tyler J. , Efron Philip A. , Remy Kenneth E. , Brakenridge Scott C. , Badovinac Vladimir P. , Griffith Thomas S. , Moldawer Lyle L. , Hotchkiss Richard S. , Caldwell Charles C. 
Published: October 2024

IntroductionSepsis is a complex clinical syndrome characterized by a heterogenous host immune response. Historically, static protein and transcriptomic metrics have been employed to describe the underlying biology. Here, we tested the hypothesis that ex vivo functional TNF expression as well as an immunologic endotype based on both IFNγ and TNF expression could be used to model clinical outcomes in sepsis patients.MethodsThis prospective, observational study of patient samples collected from the SPIES consortium included patients at five health systems enrolled over 17 months, with 46 healthy control patients, 68 ICU patients without sepsis, and 107 ICU patients with sepsis. Whole blood was collected on day 1, 4, and 7 of ICU admission. Outcomes included in-hospital and 180-day mortality and non-favorable discharge disposition defined by skilled nursing facility, long-term acute care facility, or hospice. Whole blood ELISpot assays were conducted to quantify TNF expression [stimulated by lipopolysaccharide (LPS)] and IFNγ expression (stimulated by anti-CD3/CD28 mAb), which were then used for assignment to one of four subgroups including an ‘immunocompetent’, ‘immunosuppressed endotype’, and two ‘mixed’ endotypes.ResultsWhole blood TNF spot-forming units were significantly increased in septic and CINS patients on days 4 and 7 compared to healthy subjects. In contrast, TNF expression per cell on days 1, 4, and 7 was significantly lower in both septic and critically ill non-septic (CINS) patients compared to healthy subjects. Early increases in total TNF expression were associated with favorable discharge disposition and lower in-hospital mortality. ‘Immunocompetent’ endotype patients on day 1 had a higher proportion of favorable to non-favorable discharges compared to the ‘immunosuppressed’ endotype. Similarly, ‘immunocompetent’ endotype patients on day 4 had a higher in-hospital survival compared to the ‘immunosuppressed’ endotype patients. Finally, among septic patients, decreased total TNF and IFNγ expression were associated with 180-day mortality.ConclusionsIncreased ex vivo whole blood TNF expression is associated with improved clinical outcomes. Further, the early ‘immunocompetent’ endotype is associated with favorable discharge and improved in-hospital and 180-day survival. The ability to functionally stratify septic patients based on blood cell function ex vivo may allow for identification of future immune modulating therapies.
Metapragmatic reflections of adolescents on gender in ironic interactions
Authors: Hess Zimmermann Karina , Avecilla-Ramírez Gloria Nélida , Castillo Romo Abryl Angélica 
Published: October 2024

IntroductionWhile verbal irony is a pragmatic skill that plays a very important role in social interactions, its development has not been sufficiently studied, especially in the context of the Spanish language. This research aims to generate a deeper understanding of the development of irony, specifically among Mexican adolescents. One of the pragmatic aspects identified as an important factor to consider in the comprehension and production of verbal irony is the gender of the participants involved in the communicative interaction. Prior research with adults indicates that ironic statements produced by men are generally associated with positive discursive functions, whereas those made by women are often perceived negatively. This study aims to analyze the metapragmatic reflections of 37 Mexican adolescents aged 12 and 15 years old (20 and 17 participants, respectively, half women) on how the gender of the interlocutors influences the use of irony in various communicative situations.MethodsParticipants were presented with eight written scenarios that concluded with a written ironic statement (in order to minimize the effects of prosody). The scenarios were counterbalanced to account for the type of ironic remark (critical or praise irony), the gender of the ironist, and the gender of the audience. Through a semi- structured oral interview, the adolescents' reflections and the rationale behind their responses were examined.ResultsThe results revealed significant differences in the interpretation of irony based on age, type of statement (criticism or praise), and the gender of the interlocutors, though not with respect to the gender of the audience. Additionally, a discrepancy was observed between the metapragmatic reflections expressed by adolescents regarding ironic statements and their actual interpretation of irony.DiscussionThese findings suggest that during adolescence, individuals develop an increasing capacity to consider factors related to gender roles that influence the pragmatic interpretation of ironic statements.
Methylene blue therapy in addition to standard treatment for acute-phase septic shock: a pilot randomized controlled trial
Authors: Luis-Silva Fabio , Menegueti Mayra Gonçalves , Peres Leandro Moreira , Sepeda Corina dos Reis , Jordani Maria Cecília , Mestriner Fabiola , Petroski-Moraes Bruno Cesar , Brito-de-Sousa Joaquim Pedro , Costa-Rocha Ismael Artur , Cruz Bruna Lemos , Donadel Mariana Dermínio , de Souza Felipe Barizza , Reis Gustavo Henrique Martins , Bellissimo-Rodrigues Fernando , Basile-Filho Anibal , Becari Christiane , Evora Paulo Roberto Barbosa , Martins-Filho Olindo Assis , Auxiliadora-Martins Maria 
Published: October 2024

PurposeMethylene blue (MB) has been used to increase blood pressure in patients with septic shock by acting on guanylate cyclase and nitric oxide synthase.ObjectiveTo determine whether the administration of MB to patients in the initial phase of septic shock leads to a reduction in the use of vasopressors compared to the Control group.MethodsThis was a 1:1 randomized clinical trial of two groups (MB and Control). Forty-two patients were included in the present study; 23 patients were allocated to the Control group, and 19 were randomized to the MB group. Both groups had access to standard treatment, consisting of fluid replacement, vasopressors, and antibiotic therapy. Patients received a loading dose of MB (3 mg/kg) and maintenance (0.5 mg/kg/h) for 48 h. Vasopressor doses, laboratory test results, inflammatory and anti-inflammatory cytokine levels, and hemodynamic monitoring were recorded before the infusion of MB (T1) and after 20 min (T2), 2 h (T3), 24 h (T4), 48 h after the infusion started (T5) and 24 h after weaning (T6).ResultsMB therapy was started together with the indication of vasopressin (VAS) as a second vasopressor. The MB group showed an immediate reduction in NOR dosage, an earlier reduction in VAS dosage, and higher IL-10 levels compared to the Control group.ConclusionEarly administration of MB in combination with standard treatment for septic shock might be reduce vasopressors dose. Continuous infusion of MB for 48 h was considered safe and there was no adverse events. These results highlight the potential of MB as a safe adjuvant therapeutic option in the treatment of septic shock.Clinical trial registrationhttps://clinicaltrials.gov/, identifier RBR-96584w4.
Emergence of lineage ST150 and linezolid resistance in Enterococcus faecalis: a molecular epidemiology study of UTIs in Tehran, Iran
Authors: Seyedolmohadesin Maryam , Kouhzad Mobina , Götz Friedrich , Ashkani Maedeh , Aminzadeh Soheila , Bostanghadiri Narjess 
Published: October 2024

BackgroundUrinary tract infections (UTIs) represent one of the most prevalent bacterial infections, with Enterococcus species now recognized as the second leading cause of these infections. This study focused on symptomatic UTI cases to investigate the risk factors associated with Enterococcus faecalis clinical isolates in patients from Tehran, Iran.MethodsUrine samples were collected from patients presenting with symptomatic UTIs. The identification of E. faecalis isolates was performed using standard microbiological techniques, with confirmation via polymerase chain reaction (PCR). Antibiotic susceptibility testing was conducted using the Kirby–Bauer disc diffusion method. The presence of virulence genes was determined through PCR, and biofilm formation was assessed using the microtiter plate method. Additionally, multi-locus sequence typing (MLST) was utilized to genotype linezolid-resistant isolates.ResultsOut of 300 UTI cases, E. faecalis was identified as the causative agent in 160 instances. Notably, a high proportion of these isolates exhibited resistance to tetracycline (83.8%) and minocycline (82.5%). Linezolid resistance was observed in 1.3% (n = 2) of the isolates. Conversely, the highest susceptibility rates were observed for vancomycin, penicillin G, ampicillin, and nitrofurantoin, each demonstrating a 98.8% susceptibility rate. Biofilm formation was detected in 25% of the E. faecalis isolates. A significant majority (93.8%) of the isolates harbored the efbA and ace genes, with varying frequencies of esp (72.5%), asa1 (61.2%), cylA (52.5%), and gelE (88.8%) genes. MLST analysis demonstrated that both linezolid-resistant isolates, characterized by strong biofilm formation and the presence of virulence genes, were assigned to the ST150 lineage, which has not been previously documented in clinical settings.ConclusionThe emergence of the ST150 clonal lineage, underscores its clinical significance, particularly in relation to linezolid resistance in E. faecalis. This study adds to the growing body of evidence linking specific clonal lineages with antibiotic resistance, highlighting the critical need for ongoing surveillance and molecular characterization of resistant pathogens.
3'UTR of tobacco vein mottling virus regulates downstream GFP expression and changes in host gene expression
Authors: Sun Zhenqi , Liu Dongyang , Li Bin , Yan Fangfang , Wang Yuhu , Yang Tianqi , Wang Haijuan , Xu Jiaxin , Zhou Hongyou , Zhao Mingmin 
Published: October 2024

IntroductionTobacco vein mottling virus (TVMV) is a member of the family Potyviridae. The 3’ untranslated region (3’UTR) of viral genomic RNA has been reported to significantly impact viral infection. Nevertheless, the role of the TVMV 3’UTR during viral infection remains unknown.MethodsHere, a 3’UTR-GFP expression vector was transiently expressed in Nicotiana benthamiana, in which the 3’UTR of TVMV was introduced upstream of the green fluorescent protein (GFP) gene. Transcriptome sequencing was performed to analyze the genes associated with plant resistance. The effect of the TVMV 3’UTR on GFP expression was studied using an Agrobacterium-mediated transient expression assay, revealing that the TVMV 3’UTR significantly inhibited GFP expression. Transcriptome analysis of differentially expressed genes in 3’UTR-GFP in N. benthamiana was performed to elucidate the why the TVMV 3’UTR inhibited GFP expression.ResultsEighty genes related to plant disease resistance were differentially expressed, including 29 upregulated and 51 downregulated genes. Significantly upregulated genes included those encoding the calcium-binding protein CML24, leucine-rich repeat receptor-like tyrosine-protein kinase, and respiratory burst oxidase homolog protein E. The significantly downregulated genes included calcium-binding protein 7, ethylene-responsive transcription factor 10, endoglucanase 5, and receptor-like protein kinase.DiscussionThese findings indicate that the 3’UTR of TVMV may inhibit the expression of GFP gene by inducing the expression of plant resistance genes. This study provides a theoretical basis for further research on the function and mechanism of the TVMV 3’UTR.