bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term evaluation of painful symptoms and fertility after surgery for large rectovaginal endometriosis nodule: a retrospective study
Authors: Bourdel Nicolas , Comptour Aurélie , Bouchet Paméla , Gremeau Anne‐Sophie , Pouly Jean‐Luc , Slim Karem , Pereira Bruno , Canis Michel 
Published: November 2017

AbstractIntroductionOptimal surgical treatment of rectovaginal endometriosis remains a controversial topic. The objective of this study was to evaluate long‐term postoperative outcomes after rectal shaving or colorectal resection for rectovaginal endometriosis.Material and methods195 patients underwent surgery (172 managed by shaving, 23 by colorectal resection) between January 2000 and June 2013 for rectovaginal endometriosis (>2 cm) involving at least the serosa of the rectum. Primary outcome measures were pain and fertility. Secondary outcome measures were complications, recurrence rates and quality of life.ResultsMean follow‐up was 60 ± 42 months in the shaving group and 67 ± 47 months in the resection group. The mean VAS score for pelvic pain between the pre and postoperative period decreased from 5.5 ± 3.5 (shaving group) and 7.3 ± 2.9 (resection group) to 2.3 ± 2.4 (p < 0.001) and 2.0 ± 1.8 (p < 0.001), respectively. For dysmenorrhea, the mean baseline VAS score fell postoperatively from 7.7 ± 2.8 (shaving group) and 8.2 ± 2.6 (resection group) to 3.3 ± 2.9 (p < 0.001) and 2.7 ± 2.7 (p < 0.001), respectively. Pregnancy rates were 73% for shaving and 69% for resection. Major complications occurred in 4% of patients in the shaving group and in 26% in the resection group (p = 0.001). Thirteen patients (7.6%) from the shaving group and none from the resection group were reoperated for suspicion of endometriosis recurrence (p = 0.37). Postoperative quality of life scores revealed no differences between the two groups.ConclusionOur study demonstrates that rectal shaving, when feasible for rectovaginal nodule (>2 cm) infiltrating the digestive serosa, has equal impact on pain and pregnancy rates compared with colorectal resection at long‐term follow‐up, with low complication and favorable pregnancy rates.
Sustained release of stem cell factor in a double network hydrogel for ex vivo culture of cord blood‐derived CD34+ cells
Authors: Zhang Yuanhao , Pan Xiuwei , Shi Zhen , Cai Haibo , Gao Yun , Zhang Weian 
Published: November 2017

AbstractObjectivesStem cell factor (SCF) is considered as a commonly indispensable cytokine for proliferation of haematopoietic stem cells (HSCs), which is used in large dosages during ex vivo culture. The work presented here aimed to reduce the consumption of SCF by sustained release but still support cells proliferation and maintain the multipotency of HSCs.Materials and methodsStem cell factor was physically encapsulated within a hyaluronic acid/gelatin double network (HGDN) hydrogel to achieve a slow release rate. CD34+ cells were cultured within the SCF‐loaded HGDN hydrogel for 14 days. The cell number, phenotype and functional capacity were investigated after culture.ResultsThe HGDN hydrogels had desirable properties and encapsulated SCF kept being released for more than 6 days. SCF remained the native bioactivity, and the proliferation of HSCs within the SCF‐loaded HGDN hydrogel was not affected, although the consumption of SCF was only a quarter in comparison with the conventional culture. Moreover, CD34+ cells harvested from the SCF‐loaded HGDN hydrogels generated more multipotent colony‐forming units (CFU‐GEMM).ConclusionThe data suggested that the SCF‐loaded HGDN hydrogel could support ex vivo culture of HSCs, thus providing a cost‐effective culture protocol for HSCs.
Seventy years of stream‐fish collections reveal invasions and native range contractions in an Appalachian (USA) watershed
Authors: Buckwalter Joseph D. , Frimpong Emmanuel A. , Angermeier Paul L. , Barney Jacob N. 
Published: November 2017

AbstractAimKnowledge of expanding and contracting ranges is critical for monitoring invasions and assessing conservation status, yet reliable data on distributional trends are lacking for most freshwater species. We developed a quantitative technique to detect the sign (expansion or contraction) and functional form of range‐size changes for freshwater species based on collections data, while accounting for possible biases due to variable collection effort. We applied this technique to quantify stream‐fish range expansions and contractions in a highly invaded river system.LocationUpper and middle New River (UMNR) basin, Appalachian Mountains, USA.MethodsWe compiled a 77‐year stream‐fish collections dataset partitioned into ten time periods. To account for variable collection effort among time periods, we aggregated the collections into 100 watersheds and expressed a species’ range size as detections per watershed (HUC) sampled (DPHS). We regressed DPHS against time by species and used an information‐theoretic approach to compare linear and nonlinear functional forms fitted to the data points and to classify each species as spreader, stable or decliner.ResultsWe analysed changes in range size for 74 UMNR fishes, including 35 native and 39 established introduced species. We classified the majority (51%) of introduced species as spreaders, compared to 31% of natives. An exponential functional form fits best for 84% of spreaders. Three natives were among the most rapid spreaders. All four decliners were New River natives.Main conclusionsOur DPHS‐based approach facilitated quantitative analyses of distributional trends for stream fishes based on collections data. Partitioning the dataset into multiple time periods allowed us to distinguish long‐term trends from population fluctuations and to examine nonlinear forms of spread. Our framework sets the stage for further study of drivers of stream‐fish invasions and declines in the UMNR and is widely transferable to other freshwater taxa and geographic regions.
Treatment of Helicobacter pylori infection: A clinical practice update
Authors: Zagari Rocco Maurizio , Rabitti Stefano , Eusebi Leonardo Henry , Bazzoli Franco 
Published: November 2017

AbstractBackgroundHelicobacter pylori infection is still frequent in the community and all infected subjects should be offered an eradication therapy. Nowadays physicians have to face the challenge of antibiotic resistance in treating Helicobacter pylori‐infected individuals.AimThis review provides an overview of current international guidelines and reports recent evidence from systematic reviews and clinical trials on the treatment of Helicobacter pylori infection and should help physicians to better treat their patients.ResultsGeneral rules to optimize the management of Helicobacter pylori infection include: (i) considering previous patient's exposure to antibiotics; (ii) using high dose of proton‐pump inhibitors; and (iii) avoiding repeating the same regimen, if it has already failure. Bismuth quadruple therapy and concomitant therapy are the best first‐line empirical treatments in areas with high clarithromycin resistance and in individuals with previous use of macrolides; otherwise, the 14‐day clarithromycin‐containing triple therapy is a valid regimen. The sequential therapy is no longer a suggested treatment by international guidelines.ConclusionsCurrent international guidelines are consistent in defining treatment strategies for Helicobacter pylori infection. The use of national registries to monitor the efficacy and tolerability of different regimens in the real world of clinical practice is now needed.
Community structure of insect herbivores is driven by conservatism, escalation and divergence of defensive traits in Ficus
Authors: Volf Martin , Segar Simon T. , Miller Scott E. , Isua Brus , Sisol Mentap , Aubona Gibson , Šimek Petr , Moos Martin , Laitila Juuso , Kim Jorma , Zima Jan , Rota Jadranka , Weiblen George D. , Wossa Stewart , Salminen Juha‐Pekka , Basset Yves , Novotny Vojtech 
Published: November 2017

AbstractEscalation (macroevolutionary increase) or divergence (disparity between relatives) in trait values are two frequent outcomes of the plant‐herbivore arms race. We studied the defences and caterpillars associated with 21 sympatric New Guinean figs. Herbivore generalists were concentrated on hosts with low protease and oxidative activity. The distribution of specialists correlated with phylogeny, protease and trichomes. Additionally, highly specialised Asota moths used alkaloid rich plants. The evolution of proteases was conserved, alkaloid diversity has escalated across the studied species, oxidative activity has escalated within one clade, and trichomes have diverged across the phylogeny. Herbivore specificity correlated with their response to host defences: escalating traits largely affected generalists and divergent traits specialists; but the effect of escalating traits on extreme specialists was positive. In turn, the evolution of defences in Ficus can be driven towards both escalation and divergence in individual traits, in combination providing protection against a broad spectrum of herbivores.
Considerations in performing and analyzing the responses of cortico‐cortical evoked potentials in stereo‐EEG
Authors: Prime David , Rowlands David , O'Keefe Steven , Dionisio Sasha 
Published: November 2017

SummaryThis review aims to highlight key considerations when performing cortico‐cortical evoked potentials (CCEPs) using stereo–electroencephalography (SEEG) for network mapping and show its clinical applicability to presurgical evaluations. The parameters for performing stimulation and safety aspects have been investigated in electrocorticography (ECoG) and deep brain stimulation (DBS), but not as extensively in SEEG. A review of current literature was performed, with an attempt made to emphasize practical insights from all modalities of intracranial stimulation. This paper reviews physical stimulation parameters, highlights safety limits, and considers the influence of changing common stimulation parameters. These factors are put into the context of CCEPs in SEEG. Given the paucity of direct research in this area, studies utilizing low frequency stimulation, DBS, and ECoG are incorporated along with the fundamental principles of electrical engineering. In addition, postprocessing considerations are reviewed, including electrode localization, application of digital filters, baseline selection, application of connectivity metrics, and higher order network analysis. The aim is to guide CCEP stimulation as well as to provide an understanding of the underlying principles of this technique. At present, there are few articles detailing the design of low‐frequency stimulation paradigms, especially in the setting of SEEG. Providing a review of the fundamentals and postprocessing considerations when performing CCEPs in SEEG will increase the accessibility of this technique.
SGLT‐2 inhibitors and ketoacidosis: a disproportionality analysis in the World Health Organization's adverse drug reactions database
Authors: Ado Moumouni Abdel Nasser , Robin Perrine , Hillaire‐Buys Dominique , Faillie Jean‐Luc 
Published: November 2017

AbstractSGLT‐2 inhibitors, also called gliflozins, are a new class of drugs used in type 2 diabetes. Since their marketing, several cases of ketoacidosis, including life‐threatening conditions, were reported with their use. The objective of this study was to investigate the disproportionality of pharmacovigilance reports of ketoacidosis between gliflozins and other drugs used for type 2 diabetes. We performed a case–noncase study within the World Health Organization's pharmacovigilance database, VigiBase. We selected all reports of serious adverse drug reaction associated with a glucose‐lowering drug in patients aged 40 years and older, from January 2013 to March 2016. Cases were the reports of ketoacidosis and noncases were all other serious adverse drug reactions reported. We studied the disproportionality of reports of ketoacidosis for gliflozins by calculating reporting odds ratios (ROR) with their 95% confidence interval (95% CI). We also measured the disproportionality before the warnings issued by the US and European medicines agencies. A total of 68 555 notifications were selected. We identified 487 cases of ketoacidosis exposed to gliflozins. Ketoacidosis was significantly more frequently reported with gliflozins than with other glucose‐lowering drugs (adjusted ROR 15.5; 95% CI: 12.8–18.7). The disproportionality of gliflozin reports was also found before the alerts of the medicines agencies. Our study shows a significant and early pharmacovigilance signal which suggests an increased risk of ketoacidosis associated with the use of gliflozins in patients with diabetes. Further studies are needed to confirm this potential risk.
Exploring tropical fisheries through fishers’ perceptions: Fishing down the food web in the Tonlé Sap, Cambodia
Authors: KC K. B. , Bond N. , Fraser E. D. G. , Elliott V. , Farrell T. , McCann K. , Rooney N. , Bieg C. 
Published: November 2017

AbstractTropical fisheries are among the most productive fisheries in the world, often providing the primary source of protein for the local population. Despite their importance, data on these systems are relatively limited, thus hampering management and policy development. Here, the implications of increasing fishing pressure are explored by critically evaluating the perceptions of the fishers who rely on these ecosystems to survive. A total of 169 fishers in 26 different fish‐dependent communities in the Tonlé Sap Lake, Cambodia, were surveyed to understand their perceptions of the impact that fishing has had on the ecosystem. The Tonlé Sap is one of the largest, yet poorest studied, freshwater fisheries in the world. Consistent with “fishing down the food web” theory of fisheries, survey data revealed that although fishers observed the total size of fish catch remaining consistent over recent years there has been a drastic decline in the size of individual fish, as well as a reduction in the diversity of species caught. These perceptions are examined with reference to food web theories that explore how fishing pressure leads to ecosystem change, including the more recent “indiscriminate fisheries” theory.
Combining fishers’ knowledge and cost‐effective monitoring tools in the management of marine recreational fisheries: A case study of the squid and cuttlefish fishery of the Ría of Vigo (NW Spain)
Authors: Palas S. , Villasante S. , Pita P. 
Published: November 2017

AbstractA new methodology based in the use of fishers’ knowledge and cost‐effective tools to obtain information about marine recreational fisheries (MRF) is presented. The squid and cuttlefish fishery of the Ría of Vigo (NW Spain) was selected because it is managed in a data‐poor environment. In‐depth interviews (57) were conducted with fishers, collecting ecological and socio‐economic information. A cartography of fishing grounds based on their knowledge was obtained, while the intensity of effort and catches was mapped by the monitoring of two vessels with low‐cost GPS data loggers. The 102 shore anglers and 248 recreational boats catch 8 t/year of European squid Loligo vulgaris and 11 t/year of common cuttlefish Sepia officinalis (11% of total catches on these species in the area). Shore anglers fish from 11 ports, while boat fishers use 14 fishing grounds (covering 30 km2). Most of the catches (86%) are landed by boats, and their CPUE is higher in the outer part of the Ría of Vigo. The use of fishers’ knowledge and cost‐effective monitoring is encouraged to obtain information for the management of MRF. Given the economic contribution of MRF (260,000 €/year in direct expenses), this activity should be considered in the regulations.
Rapid salinity changes affect the survival and physiology of a penaeid prawn: Implications of flood events on recruitment to the fishery
Authors: Tyler K. J. , Becker A. , Moltschaniwskyj N. A. , Taylor M. D. 
Published: November 2017

AbstractEstuaries act as nurseries for many penaeid prawns, but these habitats are highly susceptible to salinity decline through flooding. The rate of salinity decline and duration of exposure to non‐optimal salinity may affect survival and subsequent recruitment of prawns to the fishery. This study aimed to determine the effect of salinity fluctuations observed in local estuaries during flood events using a novel dilution approach. Mortality of juvenile Melicertus plebejus (Hess) was assessed after 24 hr exposure to 24 rates of salinity decline ranging from 0.01% to 20% per hr. After the salinity decline, prawns were held at the final salinities for five days before again assessing mortality as well as aerobic metabolic rate and prawn water content. Salinity decline from 36 to ~0.8 led to 50% mortality, but continued exposure to low salinity for five days increased mortality at this salinity to 99% and shifted the 50% mortality point to salinity ~5. Aerobic metabolic rate and water content data suggested the cause of mortality due to exposure to salinities < 5 was osmoregulatory failure. Rapid salinity declines over 24 hr and sustained low salinity due to flooding could compromise the survival of juvenile prawns, potentially reducing recruitment to the fishery.
The randomised response technique: A valuable approach to monitor pathways of aquatic biological invasions
Authors: Cerri J. , Ciappelli A. , Lenuzza A. , Nocita A. , Zaccaroni M. 
Published: November 2017

AbstractAnglers can be significant vectors for non‐native species (NNS) in freshwater ecosystems, and monitoring their behaviour can be a useful way to counteract biological invasions. However, anglers may be unwilling to reveal their real behaviour in conventional surveys. In this study, the Randomised Response Technique (RRT) and the Bean Method (BM) survey technique were compared using direct questions to obtain frequency estimates of four angler behaviours that may affect NNS management in freshwater ecosystems: angling without a license, release of macroinvertebrates in the environment, use of fish bait and unauthorised fish restocking. Higher estimates were obtained from responses to RRT than BM questions, and BM provided contradictory results. Use of the RRT is recommended in those human dimension studies that explore angler behaviour as a vector for aquatic invasions.
Can Antarctic lichens acclimatize to changes in temperature?
Authors: Colesie Claudia , Büdel Burkhard , Hurry Vaughan , Green Thomas George Allan 
Published: November 2017

AbstractThe Antarctic Peninsula, a tundra biome dominated by lichens and bryophytes, is an ecozone undergoing rapid temperature shifts. Such changes may demand a high physiological plasticity of the local lichen species to maintain their role as key drivers in this pristine habitat. This study examines the response of net photosynthesis and respiration to increasing temperatures for three Antarctic lichen species with different ecological response amplitudes. We hypothesize that negative effects caused by increased temperatures can be mitigated by thermal acclimation of respiration and/or photosynthesis. The fully controlled growth chamber experiment simulated intermediate and extreme temperature increases over the time course of 6 weeks. Results showed that, in contrast to our hypothesis, none of the species was able to down‐regulate temperature‐driven respiratory losses through thermal acclimation of respiration. Instead, severe effects on photobiont vitality demonstrated that temperatures around 15°C mark the upper limit for the two species restricted to the Antarctic, and when mycobiont demands exceeded the photobiont capacity they could not survive within the lichen thallus. In contrast, the widespread lichen species was able to recover its homoeostasis by rapidly increasing net photosynthesis. We conclude that to understand the complete lichen response, acclimation processes of both symbionts, the photo‐ and the mycobiont, have to be evaluated separately. As a result, we postulate that any acclimation processes in lichen are species‐specific. This, together with the high degree of response variability and sensitivity to temperature in different species that co‐occur spatially close, complicates any predictions regarding future community composition in the Antarctic. Nevertheless, our results suggest that species with a broad ecological amplitude may be favoured with on‐going changes in temperature.
Penile warty mucoepidermoid carcinoma with features of stratified mucin‐producing intra‐epithelial lesion and invasive stratified mucin‐producing carcinoma
Authors: Yorita Kenji , Kuroda Naoto , Naroda Takushi , Tamura Masato , Ohe Chisato , Divatia Mukul , Amin Mahul B , Cubilla Antonio L , Kazakov Dimitry V , Hes Ondrej , Michal Michael , Michal Michal 
Published: November 2017

AimsStratified mucin‐producing intra‐epithelial lesion (SMILE) and invasive stratified mucin‐producing carcinoma (ISMC) are recently described cervical and penile lesions. We report an unusual case of mixed variant of penile squamous cell carcinomas with warty, usual and mucoepidermoid SMILE/ISMC features.Methods and resultsA 62‐year‐old Japanese man had a glans penis lesion of one‐and‐a‐half years’ duration, suggesting malignancy. Partial penectomy and left inguinal lymphadenectomy were performed. Pathological evaluation revealed a mixed squamous cell carcinoma with warty, mucinous and usual features. The mucinous component resembled mucoepidermoid carcinoma (MEC) and SMILE/ISMC. Glandular differentiation was absent. All the diverse tumour components were negative for p16, which was confirmed by negative human papillomavirus (HPV) genotyping. The mucinous component was diffusely positive for cytokeratin 7 and largely negative for cytokeratin 5 and p63. Fluorescence in‐situ hybridisation did not detect rearrangement in the MAML2 or EWSR1 genes. The tumour was pathological stage pT2, pN1 (AJCC prognostic stage group IIIA) and was disease‐free 26 months after surgery.ConclusionsThe lack of glands in the mucinous areas suggested that MEC should be separated from adenosquamous carcinoma (ASC). Penile SMILE/ISMC may occur without dependence upon HPV status. Further studies will be necessary to determine the pathogenesis and definition of penile SMILE/ISMC, the presence of true MEC arising from the glans penis and the clinicopathological differences of penile ASC, MEC and SMILE/ISMC. Herein, we refer to the SMILE‐like penile lesion as ‘mucinous penile intra‐epithelial neoplasia’.