bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review of Recent Developments of Mesoporous Materials
Authors: Suib Steven L. 
Published: June 2017

AbstractThis personal account concerns novel recent discoveries in the area of mesoporous materials. Most of the papers discussed have been published within the last two to three years. A major emphasis of most of these papers is the synthesis of unique mesoporous materials by a variety of synthetic methods. Many of these articles focus on the control of the pore sizes and shapes of mesoporous materials. Synthetic methods of various types have been used for such control of porosity including soft templating, hard templating, nano‐casting, electrochemical methods, surface functionalization, and trapping of species in pores. The types of mesoporous materials range from carbon materials, metal oxides, metal sulfides, metal nitrides, carbonitriles, metal organic frameworks (MOFs), and composite materials. The vast majority of recent publications have centered around biological applications with a majority dealing with drug delivery systems. Several other bio‐based articles on mesoporous systems concern biomass conversion and biofuels, magnetic resonance imaging (MRI) studies, ultrasound therapy, enzyme immobilization, antigen targeting, biodegradation of inorganic materials, applications for improved digestion, and antitumor activity. Numerous nonbiological applications of mesoporous materials have been pursued recently. Some specific examples are photocatalysis, photo‐electrocatalysis, lithium ion batteries, heterogeneous catalysis, extraction of metals, extraction of lanthanide and actinide species, chiral separations and catalysis, capturing and the mode of binding of carbon dioxide (CO2), optical devices, and magneto‐optical devices. Of this latter class of applications, heterogeneous catalysis is predominant. Some of the types of catalytic reactions being pursued include hydrogen generation, selective oxidations, aminolysis, Suzuki coupling and other coupling reactions, oxygen reduction reactions (ORR), oxygen evolution reactions (OER), and bifunctional catalysis. For perspective, there have been over 40,000 articles on mesoporous materials published in the last 4 years and about 1388 reviews. By no means is this personal account thorough or all inclusive. One objective has been to choose a variety of articles of different types to obtain a flavor of the breadth of diversity involved in the area of mesoporous materials.
The comparative verification of calibration curve and background fundamental parameter methods for impurity analysis in drug materials
Authors: Furukawa Hiroaki , Ichimaru Naoto , Suzuki Keijiro , Nishino Makoto , Broughton Jennifer , Leinders Johan , Ochi Hirotomo 
Published: June 2017

The United States Pharmacopeia (USP) has established general analysis guidelines of X‐Ray fluorescence (XRF) methodology in chapter <735>, XRF spectrometry. Meanwhile, the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH Q3D) guideline, presenting a policy for limiting 24 elements such as Cd, Pb, and As in drug products and pharmaceutical ingredients, has now reached Step 5 (Implementation). The limit values of ICH Q3D are strict, for example, near or less than 1 μg/g for Cd and Pb. Moreover, there are other difficulties for accurate analysis, such as different types of matrices and the very small sample volumes in the synthesis research process for new product development in the pharmaceutical industries. Energy dispersive XRF can correct the influence of various matrices and volumes and also has the advantages of nonchemical pretreatment and nondestructive analysis. Advancements in the quantitation by fundamental parameters (FP) method using theoretical calculations, background (BG)‐FP method, leads to reduction in the number of standard samples and effectiveness on the practical elemental impurity control in pharmaceutical researches and inspections. In order to show the applicability of using the BG‐FP method, in this study, the quantitative values of some hazardous inorganic impurities for Cd, Pb, As, V, Co, and Ni in a cellulose matrix were compared by calibration curve method and BG‐FP method through the verification of USP <735>. Both methods can meet the acceptance criteria for accuracy and precision in USP <735>. Copyright © 2017 John Wiley & Sons, Ltd.
Optimization of L‐shell X‐ray fluorescence detection of lead in bone phantoms using synchrotron radiation
Authors: Gherase Mihai R. , Feng Renfei , Fleming David E. B. 
Published: June 2017

Closely related toxicity and retention mechanisms of lead (Pb) in the human body involve the bone tissues where Pb can accumulate and reside on a time scale ranging from years to tens of years. In vivo measurements of bone Pb can, therefore, play an important role in a comprehensive health risk assessment of Pb exposure. In vivo L‐shell X‐ray fluorescence (LXRF) measurement of bone Pb was first demonstrated over 4 decades ago. Implementation of the method, however, encountered challenges associated with low sensitivity and calibration procedure. In this study, the LXRF measurement was optimized by varying the incident photon energy and the excitation‐detection geometry. The Canadian Light Source synchrotron radiation was used to compare 2 different excitation‐detection geometries of 90° and 135° using 3 different X‐ray photon energies: 15.8, 16.6, and 17.5 keV. These energies optimized excitation of the L3 subshell of Pb and simulated the most intense K‐shell emissions of zirconium, niobium, and molybdenum, respectively. Five rectangular plaster‐of‐Paris bone phantoms with Pb concentrations of 0, 7, 17, 26, and 34 μg/g, and one rectangular 3.1‐mm‐thick resin phantom mimicked the X‐ray attenuation properties of human bone and soft tissue, respectively. Optimal LXRF detection was obtained by the 15.8‐keV energy and the 90° and 135° geometries for the bare bone and the bone and soft tissue phantoms, respectively.
Evaluating physician awareness of common health care costs in the emergency department
Authors: Gandhi Rohit , Stiell Ian , Forster Alan , Worthington James , Ziss Madeleine , Kitts Jack B. , Malik Ranjeeta 
Published: June 2017

AbstractBackgroundHealth care costs are on the rise in Canada and the sustainability of our health care system is at risk. As gatekeepers to patient care, emergency department (ED) physicians have a direct impact on health care costs. We aimed to identify current levels of cost awareness among ED physicians. By understanding the current level of physician cost awareness, we hope to identify areas where cost education would provide the greatest benefit in reducing ordering costs.MethodsWe conducted a survey evaluating current awareness of common ordering costs among ED physicians from two tertiary teaching hospitals. Our study population was comprised of 124, certified emergency medicine staff physicians and emergency medicine resident physicians. Our survey asked ED physicians to estimate the costs of 41 items across four categories of day-to-day ordering: imaging investigations, materials, laboratory tests, and pharmaceuticals. Items were selected based on frequency of use, availability of cost-effective alternatives, and tests considered to be “low yield”. The primary outcome was percentages of underestimates, correct estimates, and overestimates for ED costs among ED physicians.ResultsThe average percentage of correct cost estimates among ED physicians was 14% across the four ordering categories. Where cost-effective alternatives exist, ED physicians overestimated the cost of the more cost-effective item. They also underestimated the cost of low-yield tests.InterpretationED physicians demonstrated limited cost awareness of common health care costs. Further studies that characterize utilization of hospital resources based on ED physician awareness of cost-effective alternatives and cost of “low yield” tests are needed.
BOTTOM UP JUSTIFICATION, ASYMMETRIC EPISTEMIC PUSH, AND THE FRAGILITY OF HIGHER ORDER JUSTIFICATION
Authors: Kappel Klemens 
Published: June 2017

ABSTRACTWhen a first order belief accurately reflects the evidence, how should this affect the epistemic justification of a higher order belief that this is the case? In an influential paper, Kelly argues that first order evidential accuracy tends to generate more justified higher order beliefs (Kelly 2010). Call this Bottom Up. I argue that neither general views about what justifies our higher order beliefs nor the specific arguments that Kelly offers support Bottom Up. Second, I suggest that while we can reject Bottom Up, we can still accept that justified higher order beliefs significantly affect the justification of first order beliefs. Third, I argue that the epistemic justification of higher order belief is fragile in the sense that it tends to dissipate when a subject is confronted with certain defeaters, including notably the sort of defeaters arising from disagreement, precisely when higher order justification depends on first order success in the ways that one may think support Bottom Up.
Supportive factors of job and life satisfaction: Empirical evidence from disclosed lesbian, gay, and bisexual (LGB) workforce in Thailand
Authors: Punnakitikashem Prattana , Maimun Atthapong , Rakthin Sirisuhk 
Published: June 2017

AbstractThe literature exploring the impact of lesbian, gay, and bisexual (LGB) supportive employment policies on work and life satisfaction and how these relationships reflected business outcomes is largely derived from the LGB workforce in Western countries. To our knowledge, empirical evidence from LGB workforce in Thailand is very limited. To address this shortcoming, this study aims to identify and evaluate the work-related supportive factors that influence job and life satisfaction of Thai LGB employees. Theoretically, the study offers novel aspects of LGB employees’ perception toward their workplace environment in different social and cultural context of Thailand. Online surveys were administered to 144 LGB individuals, and the results highlight the effects of three types of support at work – supervisor, organizational, and coworker – on Thai LGB employees’ job and life satisfaction. The findings also provide insights for human resources managers to attract and retain LGB employees.
Understanding membrane-active antimicrobial peptides
Authors: Huang Huey W. , Charron Nicholas E. 
Published: June 2017

AbstractBacterial membranes represent an attractive target for the design of new antibiotics to combat widespread bacterial resistance to traditional inhibitor-based antibiotics. Understanding how antimicrobial peptides (AMPs) and other membrane-active agents attack membranes could facilitate the design of new, effective antimicrobials. AMPs, which are small, gene-encoded host defense proteins, offer a promising basis for the study of membrane-active antimicrobial agents. These peptides are cationic and amphipathic, spontaneously binding to bacterial membranes and inducing transmembrane permeability to small molecules. Yet there are often confusions surrounding the details of the molecular mechanisms of AMPs. Following the doctrine of structure–function relationship, AMPs are often viewed as the molecular scaffolding of pores in membranes. Instead we believe that the full mechanism of AMPs is understandable if we consider the interactions of AMPs with the whole membrane domain, where interactions induce structural transformations of the entire membrane, rather than forming localized molecular structures. We believe that it is necessary to consider the entire soft matter peptide-membrane system as it evolves through several distinct states. Accordingly, we have developed experimental techniques to investigate the state and structure of the membrane as a function of the bound peptide to lipid ratio, exactly as AMPs in solution progressively bind to the membrane and induce structural changes to the entire system. The results from these studies suggest that global interactions of AMPs with the membrane domain are of fundamental importance to understanding the antimicrobial mechanisms of AMPs.
The mouse pulvinar nucleus: Organization of the tectorecipient zones
Authors: ZHOU NA , MAIRE PHILLIP S. , MASTERSON SEAN P. , BICKFORD MARTHA E. 
Published: June 2017

AbstractComparative studies have greatly contributed to our understanding of the organization and function of visual pathways of the brain, including that of humans. This comparative approach is a particularly useful tactic for studying the pulvinar nucleus, an enigmatic structure which comprises the largest territory of the human thalamus. This review focuses on the regions of the mouse pulvinar that receive input from the superior colliculus, and highlights similarities of the tectorecipient pulvinar identified across species. Open questions are discussed, as well as the potential contributions of the mouse model for endeavors to elucidate the function of the pulvinar nucleus.
Triumph through texting: Restoring learners’ interest in grammar
Authors: Hedjazi Moghari Mona , Marandi S. Susan 
Published: June 2017

AbstractIt is usually the case that learners of English as a foreign language (EFL) are exposed to language materials in class only, and of course in such a short space of time, they do not always find enough chance to practice English grammar features and become aware of their grammar mistakes. As a potential solution to this problem, the current study inspects the impact of using cell phones, specifically text messages (via short message service) as supplementary tools, on Iranian elementary level EFL learners’ grammar learning. In the first phase of the study, 60 students aged 14 were randomly divided into experimental and comparison groups. Throughout the 12 weeks of treatment, the participants in the experimental group received 120 text messages containing grammar exercises, whereas the participants in the comparison group received a similar number of vocabulary messages as a placebo treatment and were otherwise treated exactly the same as the experimental group. A researcher-made grammar test was used to estimate whether presenting grammar exercises via text messages has any impact on language learners’ grammar learning. The results demonstrated that there was a significant difference (p<0.05) in the grammar learning of the participants who practiced grammar points through text messages and those who did not. The researchers also interviewed various stakeholders, comprising ten students, five parents, the teacher, and the school principal. A qualitative content analysis was carried out to find themes relevant to the stakeholders’ beliefs about making use of text messages for learning grammar. The findings suggest that text messages can be useful for learning grammar points, since they engage learners’ interest and encourage them to study more in order to text the correct answers when they are outside their classrooms.
Breast-feeding counselling mitigates the negative association of domestic violence on exclusive breast-feeding duration in rural Bangladesh. The MINIMat randomized trial
Authors: Frith Amy L , Ziaei Shirin , Naved Ruchira Tabassum , Khan Ashraful Islam , Kabir Iqbal , Ekström Eva-Charlotte 
Published: June 2017

AbstractObjectiveTo determine if exclusive breast-feeding counselling modifies the association of experience of any lifetime or specific forms of domestic violence (DV) on duration of exclusive breast-feeding (EBF).DesignIn the MINIMat trial pregnant women were randomized to receive either usual health messages (UHM) or usual health messages with breast-feeding counselling (BFC) in eight visits. During pregnancy (30 weeks), lifetime experience of any or specific forms of DV was measured. Infant feeding practice information was collected from 0 to 6 months at 15 d intervals.SettingMatlab, Bangladesh.SubjectsPregnant and postpartum women (n 3186) and their infants.ResultsAmong women in the UHM group, those who had experienced any lifetime DV exclusively breast-fed for a shorter duration than women who did not experience any lifetime DV (P=0·02). There was no difference, however, in duration of EBF among women in the BFC group based on their experience of any lifetime DV exposure (P=0·48). Using Cox regression analysis, there was an interaction of exposure to any lifetime DV, sexual violence and controlling behaviour, and counselling group with duration of breast-feeding at or before 6 months (P-interaction≤0·08). Among the UHM group, experience of any lifetime DV, sexual violence or controlling behaviour was associated with fewer days of EBF (P<0·05). In contrast, among the BFC group, experience of DV was not associated with duration of EBF.ConclusionsThe experience of DV compromises EBF and the support of breast-feeding counselling programmes could assist this vulnerable group towards better infant feeding practices.
The provision of ultra-processed foods and their contribution to sodium availability in Australian long day care centres
Authors: O’Halloran Siobhan A , Lacy Kathleen E , Woods Julie , Grimes Carley A , Campbell Karen J , Nowson Caryl A 
Published: June 2017

AbstractObjectivesTo categorize and assess all foods, beverages and ingredients provided over one week at Australian long day care (LDC) centres according to four levels of food processing and to assess the contribution of Na from each level of processing.DesignCross-sectional.SettingMenus for lunch, morning and afternoon snacks were collected from LDC centres. The level of food processing of all foods, beverages and ingredients was assessed utilizing a four-level food processing classification system: minimally processed (MP), processed culinary ingredients (PCI), processed (P) and ultra-processed (ULP).ResultsA total of thirty-five menus (lunch,n35; snacks,n70) provided to 1–5-year-old children were collected from seven LDC centres. Proportions of foodstuffs classified as MP, PCI, P and ULP were 54, 10, 15 and 21 %, respectively. All lunches were classified as MP. ULP foods accounted for 6 % of morning snacks; 41 % of afternoon snacks. Mean daily amount of Na provided per child across all centres was 633 (sd151) mg. ULP foods provided 40 % of Na, followed by P (35 %), MP (23 %) and PCI (2 %).ConclusionsCentres provided foods resulting in a mean total daily Na content that represented 63 % of the recommended Upper Level of Intake for Na in this age group. A significant proportion of ULP snack foods were included, which were the major contributor to total daily Na intake. Replacement of ULP snack foods with MP lower-Na alternatives is recommended.
Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells
Authors: Mansouri Rafik , Jouan Yohann , Hay Eric , Blin-Wakkach Claudine , Frain Monique , Ostertag Agnès , Le Henaff Carole , Marty Caroline , Geoffroy Valérie , Marie Pierre J , Cohen-Solal Martine , Modrowski Dominique 
Published: June 2017

AbstractStimulating bone formation is an important challenge for bone anabolism in osteoporotic patients or to repair bone defects. The osteogenic properties of matrix glycosaminoglycans (GAGs) have been explored; however, the functions of GAGs at the surface of bone-forming cells are less documented. Syndecan-2 is a membrane heparan sulfate proteoglycan that is associated with osteoblastic differentiation. We used a transgenic mouse model with high syndecan-2 expression in osteoblasts to enrich the bone surface with cellular GAGs. Bone mass was increased in these transgenic mice. Syndecan-2 overexpression reduced the expression of receptor activator of NF-kB ligand (RANKL) in bone marrow cells and strongly inhibited bone resorption. Osteoblast activity was not modified in the transgenic mice, but bone formation was decreased in 4-month-old transgenic mice because of reduced osteoblast number. Increased proteoglycan expression at the bone surface resulted in decreased osteoblastic and osteoclastic precursors in bone marrow. Indeed, syndecan-2 overexpression increased apoptosis of mesenchymal precursors within the bone marrow. However, syndecan-2 specifically promoted the vasculature characterized by high expression of CD31 and Endomucin in 6-week-old transgenic mice, but this was reduced in 12-week-old transgenic mice. Finally, syndecan-2 functions as an inhibitor of Wnt-β-catenin–T-cell factor signaling pathway, activating glycogen synthase kinase 3 and then decreasing the Wnt-dependent production of Wnt ligands and R-spondin. In conclusion, our results show that GAG supply may improve osteogenesis, but also interfere with the crosstalk between the bone surface and marrow cells, altering the supporting function of osteoblasts.
Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons
Authors: Gerónimo-Olvera Cristian , Montiel Teresa , Rincon-Heredia Ruth , Castro-Obregón Susana , Massieu Lourdes 
Published: June 2017

AbstractAutophagy is triggered during nutrient and energy deprivation in a variety of cells as a homeostatic response to metabolic stress. In the CNS, deficient autophagy has been implicated in neurodegenerative diseases and ischemic brain injury. However, its role in hypoglycemic damage is poorly understood and the dynamics of autophagy during the hypoglycemic and the glucose reperfusion periods, has not been fully described. In the present study, we analyzed the changes in the content of the autophagy proteins BECN1, LC3-II and p62/SQSTM1 by western blot, and autophagosome formation was followed through time-lapse experiments, during glucose deprivation (GD) and glucose reintroduction (GR) in cortical cultures. According to the results, autophagosome formation rapidly increased during GD, and was followed by an active autophagic flux early after glucose replenishment. However, cells progressively died during GR and autophagy inhibition reduced neuronal death. Neurons undergoing apoptosis during GR did not form autophagosomes, while those surviving up to late GR showed autophagosomes. Calpain activity strongly increased during GR and remained elevated during progressive neuronal death. Its activation led to the cleavage of LAMP2 resulting in lysosome membrane permeabilization (LMP) and release of cathepsin B to the cytosol. Calpain inhibition prevented LMP and increased the number of neurons containing lysosomes and autophagosomes increasing cell viability. Taken together, the present results suggest that calpain-mediated lysosome dysfunction during GR turns an adaptive autophagy response to energy stress into a defective autophagy pathway, which contributes to neuronal death. In these conditions, autophagy inhibition results in the improvement of cell survival.