bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new OFRMPC formulation with on‐line synthesis of the dynamic output feedback controller
Authors: Colombo Junior José Roberto , Galvão Roberto Kawakami Harrop , Assunção Edvaldo 
Published: February 2017

SummaryThis paper proposes a new approach for the design of output feedback robust model predictive control (OFRMPC) with a dynamic output feedback controller (DOFC) for linear uncertain systems subject to input and output constraints. The main contribution of this work is the full on‐line synthesis of the DOFC as part of a convex optimization problem, with constraint satisfaction and asymptotic stability guarantees. A numerical example is employed to illustrate the advantage of the proposed control law, as compared with another OFRMPC strategy with partial DOFC synthesis. The present paper also points out an inconsistency in the mathematical development of a previous related OFRMPC formulation (‘improved dynamic output feedback RMPC for linear uncertain systems with input constraints’). Copyright © 2017 John Wiley & Sons, Ltd.
Cardiomyocyte Differentiation Promotes Cell Survival During Nicotinamide Phosphoribosyltransferase Inhibition Through Increased Maintenance of Cellular Energy Stores
Authors: Kropp Erin M. , Broniowska Katarzyna A. , Waas Matthew , Nycz Alyssa , Corbett John A. , Gundry Rebekah L. 
Published: February 2017

Abstract
To address concerns regarding the tumorigenic potential of undifferentiated human pluripotent stem cells (hPSC) that may remain after in vitro differentiation and ultimately limit the broad use of hPSC-derivatives for therapeutics, we recently described a method to selectively eliminate tumorigenic hPSC from their progeny by inhibiting nicotinamide phosphoribosyltransferase (NAMPT). Limited exposure to NAMPT inhibitors selectively removes hPSC from hPSC-derived cardiomyocytes (hPSC-CM) and spares a wide range of differentiated cell types; yet, it remains unclear when and how cells acquire resistance to NAMPT inhibition during differentiation. In this study, we examined the effects of NAMPT inhibition among multiple time points of cardiomyocyte differentiation. Overall, these studies show that in vitro cardiomyogenic commitment and continued culturing provides resistance to NAMPT inhibition and cell survival is associated with the ability to maintain cellular ATP pools despite depletion of NAD levels. Unlike cells at earlier stages of differentiation, day 28 hPSC-CM can survive longer periods of NAMPT inhibition and maintain ATP generation by glycolysis and/or mitochondrial respiration. This is distinct from terminally differentiated fibroblasts, which maintain mitochondrial respiration during NAMPT inhibition. Overall, these results provide new mechanistic insight into how regulation of cellular NAD and energy pools change with hPSC-CM differentiation and further inform how NAMPT inhibition strategies could be implemented within the context of cardiomyocyte differentiation.
Sustainable Development and Performance Measurement: Global Productivity Decomposition
Authors: Kurniawan Robi , Managi Shunsuke 
Published: February 2017

AbstractThis paper analyzes productivity and efficiency by using inclusive wealth as a sustainability measurement. The study extends current measures of sustainability by capturing the efficient utilization of natural capital and other conventional inputs as input and carbon damage as undesirable output in a productivity measure for 140 countries from 1995 to 2010. To determine the contribution of each input/output to productivity and technical efficiency, we applied a weighted Russell directional distance and a Luenberger productivity measure. We found that GDP, natural capital and carbon damage are the main contributors to productivity change. Natural capital and carbon damage remain significant burdens for many countries' performance, especially for countries with resource‐driven economies and extreme vulnerability to climatic shifts. This finding enhances our understanding of how particular countries can measure and manage their sustainability. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Engaging with socially acute questions: Development and validation of an interactional reasoning framework
Authors: Morin Olivier , Simonneaux Laurence , Tytler Russell 
Published: February 2017

AbstractScientific expertise and outcomes often give rise to controversy. An educational response that equips students to take part in socioscientific discussions is the teaching of Socially Acute Questions (SAQs). Students engaging with SAQs need to engage with socio scientific reasoning, which involves reasoning with evidence from a variety of fields other than science, including values, economics, local and global perspectives, governance issues, and a variety of stakeholder perspectives. This paper describes research in which tertiary students from France and Australia engaging with sustainability SAQs reasoned responses in wikis. In previous analyses (Morin et al., 2013), we have developed a six‐dimensional framework of socioscientific sustainability reasoning (S3R). In this paper, we describe the development of an interactional reasoning framework that captures the quality of reasoning in the online discussions that led to specific improvement in S3R. The framework draws on and extends the discourse framework of Mercer, and Habermas’ three worlds of validity of arguments to identify first that a particular category—integrated exploratory talk—is associated with improvement in S3R, and that this almost exclusively involves exchanges drawing on personal and social evidence claims as well as technical. We explore the implications for supporting collaborative decision making in socio scientific issues, for democratic participation and for post normal science education. © 2017 Wiley Periodicals, Inc. J Res Sci Teach 54: 825–851, 2017
Role of miRNAs in human disease and inborn errors of metabolism
Authors: Rivera‐Barahona Ana , Pérez Belén , Richard Eva , Desviat Lourdes R. 
Published: February 2017

AbstractMicroRNAs (miRNAs) are short, noncoding RNAs that regulate gene expression posttranscriptionally by base pairing with target messenger RNAs (mRNAs). They are estimated to target ∼60% of all human protein‐coding genes and are involved in regulating key physiological processes and intracellular signaling pathways. They also exhibit tissue specificity, and their dysregulation is linked to the progression of pathology. Identifying disease associated miRNAs and their respective targets provides novel molecular insight into disease, enabling the design of new therapeutic strategies. Notably, miRNAs are present in stable form in biological fluids, making them amenable to routine clinical processing and analysis, which has paved the way for their use as novel biomarkers of disease and response to therapy. One of the most relevant findings in miRNA research concerns the therapeutic modulation of specific miRNA levels in vitro and in vivo, which has led to miRNA‐based drugs entering clinical trials. Most studies relative to miRNA profiling, association with pathology, and therapeutical modulation have been conducted for cancer, cardiovascular and neurodegenerative diseases. However, for different monogenic diseases, including inborn errors of metabolism (IEM), research contributing to alterations to physiopathology caused by miRNAs is steadily increasing. Herein, we review the biogenesis pathway and mode of miRNA action, their known roles in disease states, and use of circulating miRNAs as biomarkers, describing the available research tools for basic and clinical studies. In addition, we summarize recent literature on miRNA studies in inherited metabolic diseases.
Soybean and Soybean/Beef‐Tallow Biodiesel: A Comparative Study on Oxidative Degradation During Long‐Term Storage
Authors: Pereira Gustavo G. , Garcia Rita K. A. , Ferreira Lucas L. , Barrera‐Arellano Daniel 
Published: February 2017

AbstractVegetable oils are the primary raw materials used in biodiesel production; however, they usually present oxidative stabilities inferior to the EN 14214 specifications. An alternative to improve the oxidative quality of vegetable oil biodiesel is blending it with animal fat biodiesel. In this paper, we studied the oxidative degradation of soybean/beef‐tallow biodiesel (SB) 70/30 and 50/50 (w/w) during long‐term storage. Soybean biodiesel (SO) was used as a control sample. The biodiesel samples were stored for 350 days and analyzed periodically via oxidative stability, tocopherol content, peroxide value, polar compounds, and kinematic viscosity. The results showed that SB 70/30 and 50/50 biodiesel samples presented higher oxidative stabilities than SO biodiesel. Additionally, the blends met the limits proposed by EN 14214 for oxidative stability (8 h). During long‐term storage, the SB biodiesel showed greater resistance to oxidative degradation, which was indicated by the lower formation of hydroperoxides and polar compounds. Similarly, the decline in the tocopherol content was slower in SB biodiesel. Blends of soybean and beef‐tallow biodiesel at levels of 70/30 and 50/50 are, therefore, proper alternatives to improve the oxidative quality of this biofuel.
Developing the Fourth Evaluation Dimension: A Protocol for Evaluation of Video From the Patient’s Perspective During Major Incident Exercises
Authors: Haverkort J.J. Mark , Leenen Luke P.H. 
Published: February 2017

AbstractObjectivePresently used evaluation techniques rely on 3 traditional dimensions: reports from observers, registration system data, and observational cameras. Some of these techniques are observer-dependent and are not reproducible for a second review. This proof-of-concept study aimed to test the feasibility of extending evaluation to a fourth dimension, the patient’s perspective.MethodsFootage was obtained during a large, full-scale hospital trauma drill. Two mock victims were equipped with point-of-view cameras filming from the patient’s head. Based on the Major Incident Hospital’s first experience during the drill, a protocol was developed for a prospective, standardized method to evaluate a hospital’s major incident response from the patient’s perspective. The protocol was then tested in a second drill for its feasibility.ResultsNew insights were gained after review of the footage. The traditional observer missed some of the evaluation points, which were seen on the point-of-view cameras. The information gained from the patient’s perspective proved to be implementable into the designed protocol.ConclusionUse of point-of-view camera recordings from a mock patient’s perspective is a valuable addition to traditional evaluation of trauma drills and trauma care. Protocols should be designed to optimize and objectify judgement of such footage. (Disaster Med Public Health Preparedness. 2017;11:594–599)
Assessing the Likelihood of Hand-to-Hand Cross-Transmission of Bacteria: An Experimental Study
Authors: Bellissimo-Rodrigues Fernando , Pires Daniela , Soule Hervé , Gayet-Ageron Angèle , Pittet Didier 
Published: February 2017

BACKGROUNDAlthough the hands of healthcare workers (HCWs) are implicated in most episodes of healthcare-associated infections, the correlation between hand contamination and the likelihood of cross-transmission remains unknown.METHODSWe conducted a laboratory-based study involving pairs of HCWs. The hands of a HCW (transmitter) were contaminated with Escherichia coli ATCC 10536 before holding hands with another HCW (host) for 1 minute. Meanwhile, the unheld hand of the transmitter was sampled. Afterward, the host’s held hand was also sampled. Each experiment consisted of 4 trials with increasing concentrations of E. coli (103–106 colony-forming units [cfu]/mL). The primary outcome was the likelihood of transmission of at least 1 cfu from transmitter to host. We used a mixed logistic regression model with a random effect on the subject to assess the association between transmission and bacterial count on the transmitter’s hands.RESULTSIn total, 6 HCWs performed 30 experiments and 120 trials. The bacterial counts recovered from host hands were directly associated with the bacterial counts on transmitter hands (P<.001). The probability of cross-transmission was 8.22 higher (95% confidence interval [CI], 0.98–68.8) when transmitter hand bacterial count was >1 and ≤3 log10 cfu compared to ≤1 log10. When transmitter contamination was <1 log10 cfu, no cross-transmission was detected.CONCLUSIONThere is a direct relationship between the bacterial burden on HCWs hands and the likelihood of cross-transmission. Under the described conditions, at least 1 log10 cfu must be present on HCW hands to be potentially transmitted. Further studies are needed at the low contamination range.Infect Control Hosp Epidemiol 2017;38:553–558
Small-Scale Effects on the Buckling of Skew Nanoplates Based on Non-Local Elasticity and Second-Order Strain Gradient Theory
Authors: Shahriari B. , Shirvani S. 
Published: February 2017

AbstractIn recent years, nanostructures have been used in a vast number of applications, making the study of the mechanical behaviour of such structures important. In this paper, two different constitutive equations including first-order strain gradient and simplified differential non-local are employed to model the buckling behaviour of skew nanoplates. The Galerkin method is used for solving the equations in order to obtain buckling load. Using this method, the influence of different parameters consisting of non-classical properties, boundary conditions, and geometrical parameters such as length and angle on the buckling load, are studied. The results showed that small-scale effects are very important in skew graphene sheets and their inclusion results in smaller buckling loads.
Phylogenetic taxonomy and classification of the Crinoidea (Echinodermata)
Authors: Wright David F. , Ausich William I. , Cole Selina R. , Peter Mark E. , Rhenberg Elizabeth C. 
Published: February 2017

AbstractA major goal of biological classification is to provide a system that conveys phylogenetic relationships while facilitating lucid communication among researchers. Phylogenetic taxonomy is a useful framework for defining clades and delineating their taxonomic content according to well-supported phylogenetic hypotheses. The Crinoidea (Echinodermata) is one of the five major clades of living echinoderms and has a rich fossil record spanning nearly a half billion years. Using principles of phylogenetic taxonomy and recent phylogenetic analyses, we provide the first phylogeny-based definition for the Clade Crinoidea and its constituent subclades. A series of stem- and node-based definitions are provided for all major taxa traditionally recognized within the Crinoidea, including the Camerata, Disparida, Hybocrinida, Cladida, Flexibilia, and Articulata. Following recommendations proposed in recent revisions, we recognize several new clades, including the Eucamerata Cole 2017, Porocrinoidea Wright 2017, and Eucladida Wright 2017. In addition, recent phylogenetic analyses support the resurrection of two names previously abandoned in the crinoid taxonomic literature: the Pentacrinoidea Jaekel, 1918 and Inadunata Wachsmuth and Springer, 1885. Last, a phylogenetic perspective is used to inform a comprehensive revision of the traditional rank-based classification. Although an attempt was made to minimize changes to the rank-based system, numerous changes were necessary in some cases to achieve monophyly. These phylogeny-based classifications provide a useful template for paleontologists, biologists, and non-experts alike to better explore evolutionary patterns and processes with fossil and living crinoids.
Heat Kernel Estimates Under the Ricci–Harmonic Map Flow
Authors: Băileşteanu Mihai , Tran Hung 
Published: February 2017

AbstractThis paper considers the Ricci flow coupled with the harmonic map flow between two manifolds. We derive estimates for the fundamental solution of the corresponding conjugate heat equation and we prove an analogue of Perelman's differential Harnack inequality. As an application, we find a connection between the entropy functional and the best constant in the Sobolev embedding theorem in ℝn.
The cross-national epidemiology of specific phobia in the World Mental Health Surveys
Authors: Wardenaar K. J. , Lim C. C. W. , Al-Hamzawi A. O. , Alonso J. , Andrade L. H. , Benjet C. , Bunting B. , de Girolamo G. , Demyttenaere K. , Florescu S. E. , Gureje O. , Hisateru T. , Hu C. , Huang Y. , Karam E. , Kiejna A. , Lepine J. P. , Navarro-Mateu F. , Oakley Browne M. , Piazza M. , Posada-Villa J. , ten Have M. L. , Torres Y. , Xavier M. , Zarkov Z. , Kessler R. C. , Scott K. M. , de Jonge P. 
Published: February 2017

BackgroundAlthough specific phobia is highly prevalent, associated with impairment, and an important risk factor for the development of other mental disorders, cross-national epidemiological data are scarce, especially from low- and middle-income countries. This paper presents epidemiological data from 22 low-, lower-middle-, upper-middle- and high-income countries.MethodData came from 25 representative population-based surveys conducted in 22 countries (2001–2011) as part of the World Health Organization World Mental Health Surveys initiative (n = 124 902). The presence of specific phobia as defined by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition was evaluated using the World Health Organization Composite International Diagnostic Interview.ResultsThe cross-national lifetime and 12-month prevalence rates of specific phobia were, respectively, 7.4% and 5.5%, being higher in females (9.8 and 7.7%) than in males (4.9% and 3.3%) and higher in high- and higher-middle-income countries than in low-/lower-middle-income countries. The median age of onset was young (8 years). Of the 12-month patients, 18.7% reported severe role impairment (13.3–21.9% across income groups) and 23.1% reported any treatment (9.6–30.1% across income groups). Lifetime co-morbidity was observed in 60.5% of those with lifetime specific phobia, with the onset of specific phobia preceding the other disorder in most cases (72.6%). Interestingly, rates of impairment, treatment use and co-morbidity increased with the number of fear subtypes.ConclusionsSpecific phobia is common and associated with impairment in a considerable percentage of cases. Importantly, specific phobia often precedes the onset of other mental disorders, making it a possible early-life indicator of psychopathology vulnerability.
A constraint-based approach for planning unmanned aerial vehicle activities
Authors: Guettier Christophe , Lucas François 
Published: February 2017

AbstractUnmanned Aerial Vehicles (UAV) represent a major advantage in defense, disaster relief and first responder applications. UAV may provide valuable information on the environment if their Command and Control (C2) is shared by different operators. In a C2 networking system, any operator may request and use the UAV to perform a remote sensing operation. These requests have to be scheduled in time and a consistent navigation plan must be defined for the UAV. Moreover, maximizing UAV utilization is a key challenge for user acceptance and operational efficiency. The global planning problem is constrained by the environment, targets to observe, user availability, mission duration and on-board resources. This problem follows previous research works on automatic mission Planning & Scheduling for defense applications. The paper presents a full constraint-based approach to simultaneously satisfy observation requests, and resolve navigation plans.
Introduction to the special issue on constraint satisfaction for planning and scheduling
Authors: Salido Miguel A. , Barták Roman 
Published: February 2017

AbstractThe areas of Artificial Intelligence planning and scheduling have seen important advances thanks to the application of constraint satisfaction models and techniques. Especially, solutions to many real-world problems need to integrate plan synthesis capabilities with resource allocation, which can be efficiently managed by using constraint satisfaction techniques. Constraint satisfaction plays an important role in solving such real life problems, and integrated techniques that manage planning and scheduling with constraint satisfaction are particularly useful.
Milk kefir: nutritional, microbiological and health benefits
Authors: Rosa Damiana D. , Dias Manoela M. S. , Grześkowiak Łukasz M. , Reis Sandra A. , Conceição Lisiane L. , Peluzio Maria do Carmo G. 
Published: February 2017

AbstractKefir is fermented milk produced from grains that comprise a specific and complex mixture of bacteria and yeasts that live in a symbiotic association. The nutritional composition of kefir varies according to the milk composition, the microbiological composition of the grains used, the time/temperature of fermentation and storage conditions. Kefir originates from the Caucasus and Tibet. Recently, kefir has raised interest in the scientific community due to its numerous beneficial effects on health. Currently, several scientific studies have supported the health benefits of kefir, as reported historically as a probiotic drink with great potential in health promotion, as well as being a safe and inexpensive food, easily produced at home. Regular consumption of kefir has been associated with improved digestion and tolerance to lactose, antibacterial effect, hypocholesterolaemic effect, control of plasma glucose, anti-hypertensive effect, anti-inflammatory effect, antioxidant activity, anti-carcinogenic activity, anti-allergenic activity and healing effects. A large proportion of the studies that support these findings were conducted in vitro or in animal models. However, there is a need for systematic clinical trials to better understand the effects of regular use of kefir as part of a diet, and for their effect on preventing diseases. Thus, the present review focuses on the nutritional and microbiological composition of kefir and presents relevant findings associated with the beneficial effects of kefir on human and animal health.
Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges
Authors: Jeanes Yvonne M. , Reeves Sue 
Published: February 2017

AbstractWomen with polycystic ovary syndrome (PCOS) have a considerable risk of metabolic dysfunction. This review aims to present contemporary knowledge on obesity, insulin resistance and PCOS with emphasis on the diagnostic and methodological challenges encountered in research and clinical practice. Variable diagnostic criteria for PCOS and associated phenotypes are frequently published. Targeted searches were conducted to identify all available data concerning the association of obesity and insulin resistance with PCOS up to September 2016. Articles were considered if they were peer reviewed, in English and included women with PCOS. Obesity is more prevalent in women with PCOS, but studies rarely reported accurate assessments of adiposity, nor split the study population by PCOS phenotypes. Many women with PCOS have insulin resistance, though there is considerable variation reported in part due to not distinguishing subgroups known to have an impact on insulin resistance as well as limited methodology to measure insulin resistance. Inflammatory markers are positively correlated with androgen levels, but detailed interactions need to be identified. Weight management is the primary therapy; specific advice to reduce the glycaemic load of the diet and reduce the intake of pro-inflammatory SFA and advanced glycation endproducts have provided promising results. It is important that women with PCOS are educated about their increased risk of metabolic complications in order to make timely and appropriate lifestyle modifications. Furthermore, well-designed robust studies are needed to evaluate the mechanisms behind the improvements observed with dietary interventions.