bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulse Oximetry and Auscultation for Congenital Heart Disease Detection
Authors: Hu Xiao-jing , Ma Xiao-jing , Zhao Qu-ming , Yan Wei-li , Ge Xiao-ling , Jia Bing , Liu Fang , Wu Lin , Ye Ming , Liang Xue-cun , Zhang Jing , Gao Yan , Zhai Xiao-wen , Huang Guo-ying 
Published: September 2017

OBJECTIVES:
Pulse oximetry (POX) has been confirmed as a specific screening modality for critical congenital heart disease (CCHD), with moderate sensitivity. However, POX is not able to detect most serious and critical cardiac lesions (major congenital heart disease [CHD]) without hypoxemia. In this study, we investigated the accuracy and feasibility of the addition of cardiac auscultation to POX as a screening method for asymptomatic major CHD.

METHODS:
A multicenter prospective observational screening study was conducted at 15 hospitals in Shanghai between July 1, 2012, and December 31, 2014. Newborns with either an abnormal POX or cardiac auscultation were defined as screen positive. All screen-positive newborns underwent further echocardiography. False-negative results were identified by clinical follow-up, parents’ feedback, and telephone review. We assessed the accuracy of POX plus cardiac auscultation for the detection of major CHD.

RESULTS:
CHD screening was completed in all 15 hospitals, with a screening rate of 94.0% to 99.8%. In total, 167 190 consecutive asymptomatic newborn infants were screened, of which 203 had major CHD (44 critical and 159 serious). The sensitivity of POX plus cardiac auscultation was 95.5% (95% confidence interval 84.9%–98.7%) for CCHD and 92.1% (95% confidence interval 87.7%–95.1%) for major CHD. The false-positive rate was 1.2% for detecting CCHD and 1.1% for detecting major CHD.

CONCLUSIONS:
In our current study, we show that using POX plus cardiac auscultation significantly improved the detection rate of major CHD in the early neonatal stage, with high sensitivity and a reasonable false-positive rate. It provides strong evidence and a reliable method for neonatal CHD screening.
Immunotherapy: A New (and Old) Approach to Treatment of Soft Tissue and Bone Sarcomas
Authors: Nathenson Michael J. , Conley Anthony P. , Sausville Edward 
Published: September 2017

Abstract

Soft tissue and bone sarcomas are a rare and heterogeneous form of cancer. With standard of care treatment options including surgery, radiation, and chemotherapy, the long-term survival is still low for high-risk soft tissue sarcoma patients. New treatment strategies are needed. Immunotherapy offers a new potential treatment paradigm with great promise. Immunotherapy of soft tissue sarcomas dates back to Dr. Coley's first use of toxins in the late 1800s. A variety of strategies of immunotherapy have been tried in soft tissue and bone sarcomas, including various vaccines and cytokines, with limited success. Results of these early clinical trials with vaccines and cytokines were disappointing, but there are reasons to be optimistic. Recent advances, particularly with the use of adoptive T-cell therapy and immune checkpoint inhibitors, have led to a resurgence of this field for all cancer patients. Clinical trials utilizing adoptive T-cell therapy and immune checkpoint inhibitors in soft tissue and bone sarcomas are under way. This paper reviews the current state of evidence for the use of immunotherapy, as well as current immunotherapy strategies (vaccines, adopative T-cell therapy, and immune checkpoint blockade), in soft tissue and bone sarcomas. By understanding the tumor microenviroment of sarcomas and how it relates to their immunoresponsiveness, better immunotherapy clinical trials can be designed, hopefully with improved outcomes for soft tissue and bone sarcoma patients.

Implications for Practice
Immunotherapy is a promising treatment paradigm that is gaining acceptance for the management of several cancers, including melanoma, renal cell carcinoma, prostate cancer, and lung cancer. There is a long history of immunotherapy in the treatment of soft tissue and bone sarcomas, although with little success. It is important to understand past failures to develop future immunotherapy treatment strategies with an improved possibility of success. This article reviews the history of and current state of immunotherapy research in the treatment of soft tissue and bone sarcomas, with particular regard to vaccine trials, adoptive T-cell therapy, and immune checkpoint blockade.
Long-term temperature measurement: Biogas digesters fermenting slurry
Authors: Nekhubvi Vhutshilo , Tinarwo David 
Published: September 2017

This paper reports the results of the temperature profile of the unheated and unstirred continuous fermenting bio-slurry in a fixed-dome Deenbandhu 2000 model. The digester is a brick-built system of bulk size 6 m3. The digester was monitored for eight months, measuring internal bio-slurry temperature. A K-type nickel chromium-nickel temperature sensor with a sensitivity of approximately 41 µV and response time of 0.8s in liquids was positioned at the centre of the digester to measure the slurry temperature. The sensor was connected to the data logger and programmed to record temperature readings every second for the entire study period. The study results reported give a clear indication about the reaction of bio-slurry temperature in the digester at a local level, particularly for the eight months’ period, which covered all seasons. The calculated values of the daily average temperature reveal that the digester was operating within the range of psychrophilic 10.32 and mesophilic 28.80 , although it sometimes operated at 35 and above during certain hours in summer. This study is useful for anaerobic digestion processes for biogas production. The results obtained can be used as a basis to estimate the amount of heat required to raise the temperature of digesters to reach an optimum temperature of mesophilic digesters.
In regard to the change of the editorial board and the advisory board of the Bosnian Journal of Basic Medical Sciences
Authors: Mehić Bakir 
Published: September 2017

The most vital part of a scientific journal is the Editorial board and Advisory board. So, it is never good that the composition of these boards lasts longer than 2-3 years.
With the first number of BJBMS in 2014, a new composition of the Editorial board and Advisory Board of this journal was published. They consist of eminent scientists with adequate qualifications from nine countries and who can actively contribute to the good management of the journal and its further development. Their tasks will be:

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Supporting and promotion of the journal (being true ambassadors of the journal),

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Writing editorials, reviews and commentaries on works from the field of their expertise,

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Giving opinions and suggestions on the management and policy of the journal, with the timely identification of the upcoming challenges.

Commitment to upholding the ethics of publishing with impartiality and confidentiality, the fight against plagiarism and multiple or simultaneous publication of articles will remain a priority in the work of the Editorial Board and Advisory Board of BJBMS. Also, the newly appointed boards will continue to work in the way of protection of copyright for authors who were victims of plagiarism. In this sense, the editor in chief, together with the Editorial Board will take measures in accordance with the guidelines of the Committee for Ethics in publishing [1].
Quality assurance in publishing and also in BJBMS is focused on the detection of forged data, images, and plagiarized articles. In its future work Editorial Board of BJBMS is obliged to pay attention to supporting academic integrity, ensuring the integrity of academic records and intellectual property. This latter implies:

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Request for evidence of ethics for the approved research, that is, authors will be asked to prove that they obtained the consent of the patient for the study or in the case of experiments on animals, which methods were used so the animals would not suffer?

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Ensuring that reports of clinical trials are in accordance with the Declaration of Helsinki [2], good clinical practice [3] and other relevant guides secure participation,

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Ensuring that the reports of experiments and animal studies provided in accordance with the guide of healthy and humane service care and the use of laboratory animals [4] and of other relevant guides,

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Adopting systems for detecting plagiarism in submitted works,

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Supporting the authors whose copyright has been infringed or who were victims of plagiarism,

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Readiness in the defence of the rights of authors (i.e. demanding the withdrawal or removal of materials from websites, journals, etc.)

Regarding the above mentioned members of the new Editorial Board and Advisory Board, I wish them to achieve equally good results in forthcoming work, such as those achieved by their predecessors in the period of 2010 – 2013.
Arts audiences in Finland
Authors: Suominen Seppo 
Published: September 2017

Arts audiences in Finland
A survey conducted in 2013 by the Finnish Cultural Foundation studied Finnish views on and thoughts about culture and its consumption. About 30 % in the sample had not visited any cultural attractions or events. The main cultural activities visited or attended were theatre, museum, art exhibitions, pop music concerts and movies at a cinema. In addition to these consumers seem to favour classical music. Opera, folk music and dance events had the lowest attendance figure. Our study contributes to the literature by identifying the determinants of participation level and of each category in arts consumption in Finland. First the overall participation level is studied by employing multiple choice and ordered logit and probit models as well as a bivariate probit model. We show how different socio-economic variables explain cultural consumption in Finland. Some insights into the distribution of state subsidises is discussed.
We examine to what extent standard socio-economic variables influence attendance at different cultural events. How these variables are related to the number of cultural events participated and what are the main differences between univore and omnivore consumers? A standard economic theory assumes that the marginal utility of any consumption diminishes. Is this valid in the case of cultural events consumption? Does the assumption reflect the idea that even if the consumers’ incomes increase, still they do not participate all cultural events?
Incomes, education and learning experiences accumulated and associated with age are important factors in the demand for arts, however, there are exceptions in Finland. The demand for folk music cannot be explained by differences in household’s incomes. Folk music category is more separated and not very popular among Finnish consumers. Dance events and folk music seem to have the smallest distance and all other categories are more far away
Keywords: Finland, cultural consumption, participation, logit, probit, art audiences
Kulttuurilaitoksesta valintataloksi – yleisen kirjastolaitoksen institutionaaliset tehtävämäärittelyt ja niiden kehitys Suomen itsenäisyyden aikana
Authors: Saarti Jarmo , Tuomi Pirjo 
Published: September 2017

From civic educator to a market place - the institutional definitions of the public libraries’ tasks and its development during the Finnish independence
The development of the Finnish public library system can be divided into four phases. During the first two, the Swedish reign and the period of the Autonomy, the library was mainly for the upper classes and for the academic use. The trend to strengthen the library as a key actor in the educational system of the newborn independent Finland meant that the public library became an institution. This started to break down from the 1990’s onward with the implementation of the new public management techniques and with the integration of the library system as one of the key players in the information society development. The paper discusses the role of the Finnish library system in the system of the fictional literature and analyses the changes that have happened during the Finnish history.

Keywords: public libraries, policies, institutional role, public role
Paikkatietomenetelmät Helsingin kaupungin kulttuuripoliittisen suunnittelun tukena
Authors: Räisänen Petteri , Sariola Reetta 
Published: September 2017

GIS methods as a tool for cultural policy planning in the City of Helsinki
Geographic information research methods (GIS) are widely used as a tool in identifying information for City planning and development. This article provides an overview how GIS methods have been used for building a knowledge base for cultural policy in the City of Helsinki. The article presents four case studies, which examines GIS-based analyzing techniques for locating of cultural facilities, accessibility of cultural services and resident’s cultural participation in the City of Helsinki. Furthermore, it presents the possibilities of GIS methods for cultural policy purposes and cultural service development.
Ylirajainen kirjallisuus ja yksikielinen kirjallinen elämä Suomessa
Authors: Nissilä Hanna-Leena 
Published: September 2017

Transnational literature and monolingual literary life in Finland

The aim of the article is to analyze how the national framework structured to literary life has affected the position of transnational literature in Finland in the early 2000s – time when Finnish society has become more multicultural due to increased immigration and growing mobility of people. It discusses what challenges nationalism presents to writers with migrant backgrounds and to those who often write in languages other than Finnish, Swedish or Sami. Literary life is studied through the observations of other researchers and through mediatexts from which the experiences of transnational writers and the voice of literary institutions are construed. The methodological basis of the article come from the transnational approach which is conscious of the critique of methodological nationalism and pays attention to movements and sociocultural existence across national, cultural and linguistic borders in literary life. The article argues that, part of the structures built in literary culture do not respond to the current realities and needs of transnationalization, multilingualization and multiculturalism in the Finnish literary eld. Both the naturalized monolingual paradigm and the national de ned literary eld generate nationalistic and exclusive positions, and the authors writing in other than dominant languages may be excluded from literary institutions, canonization and even literary life.
Keywords: literary life, monolingualism, nationalism, transnationalism
Domestic Dexterity and Cultural Policy – The Idea of Cottage Industry and Historical Experience in Finland from the Great Famine to the Reconstruction Period
Authors: Kraatari Eliza 
Published: September 2017

Lektio
YTM, TaM Eliza Kraatarin kulttuuripolitiikan/valtio-opin alaan kuuluvan väitöskirjan ”Domestic Dexterity and Cultural Policy – The Idea of Cottage Industry and Historical Experience in Finland from the Great Famine to the Reconstruction Period” tarkastustilaisuus pidettiin Jyväskylän yliopistossa 16 January 2016. Vastaväittäjänä toimi yliopistonlehtori Juri Mykkänen (Helsingin yliopisto) ja kustoksena oli emeritaprofessori Anita Kangas (Jyväskylän yliopisto).
MUNICIPAL-PRIVATE PARTNERSHIP – A MECHANISM FOR THE DEVELOPMENT OF MUNICIPAL OUTPATIENT UROLOGY
Authors: Gevorkyan A. R. 
Published: September 2017

The relevance of the study is determined by the need to attract private investment in the field of municipal health care with the aim of improving the system of outpatient urological care.Purpose. To determine the vectors of development, planning, the basic conditions for the implementation of municipalprivate partnership (IMPP) in the system of municipal outpatient urological care.Materials and methods. To achieve this goal, general scientific methods of analysis, synthesis, generalization, interpretation of scientific data, as well as systemic and structural-functional approaches were applied in the work.Results. The article provides the scientific substantiation of the role of municipal-private partnership in the development of municipal outpatient urology. Methodical approaches to the formation of the outpatient center of urology with the mechanisms of the mixed economy, developing business processes involving private investor resources in the reproduction processes and increasing the efficiency of the municipal system of outpatient urological care are outlined.Conclusions. The article defines the vectors of development, planning, the main conditions for the implementation of municipal-private partnershipsin the system of municipal outpatient urological carein order to attract privateinvestments and develop an outpatient urology system.
As danças populares na obra de Mário de Andrade
Authors: Paula Roberta Cristina de 
Published: September 2017

Este estudo tem como objetivo analisar as danças na obra do escritor modernista Mário de Andrade. Para realizar tal pesquisa tomo como base, principalmente, dois textos da extensa obra do autor: "O Turista Aprendiz" e "Danças Dramáticas do Brasil", pois a partir das respectivas leituras, pude ampliar conhecimentos referentes ao universo das manifestações populares brasileiras, especificamente as danças.
História pública e literatura: reflexões sobre o discurso
Authors: Moraes Alexandre Santos de 
Published: September 2017

O artigo reflete sobre o tema do discurso no âmbito dos debates sobre História Pública. A partir da análise dos desenvolvimentos de um campo específico da Literatura Grega Arcaica, suscitamos alguns debates que permitem refletir sobre a posição dos historiadores e da audiência no movimento de produção e acesso ao discurso historiográfico.
As ações culturais do Departamento de Cultura da cidade de São Paulo através dos Parques Infantis
Authors: Garcia Lucas 
Published: September 2017

O presente trabalho tem com objetivo a discussão da gestão dos Parques Infantis pelo Departamento de Cultura da cidade de São Paulo, na década de 1930. De certo, influenciados pelo movimento modernista, os gestores aplicaram novos métodos às atividades dos parques que atendiam crianças de 3 a 12 anos de idade, filhas de operários e trabalhadores de fábricas. Dirigido por Mário de Andrade, o departamento obteve em poucos anos ótimos resultados e se tornou referência em alguns países europeus, inaugurando assim as políticas culturais no Brasil.
Fotojornalismo e história
Authors: Almeida Juniele Rabêlo de 
Published: September 2017

“Prata da Casa: fotógrafos e fotografia no Rio de Janeiro” (Eduff, 2013) apresenta, na interface história e fotojornalismo, a análise das narrativas fotográficas e das narrativas de fotógrafos, no cenário de modernização da imprensa brasileira em meados do século XX.
Ekspresi Relatif mRNA BRLF1 Epstein-Barr Virus dari Biopsi Jaringan Tumor dalam Blok Parafin sebagai Petanda Biologi Patogenesis Karsinoma Nasofaring
Authors: Estania Andreanne Poppy , Sulistyo Hidayat , Wahyono Daniel Joko 
Published: September 2017

Karsinoma nasofaring (KNF) merupakan tumor ganas pada sel epitel nasofaring dan merupakan penyakit multifaktor yang bersifat endemik. Tipe KNF tidak berdiferensiasi (KNF WHO-3) telah terbukti konsisten dengan infeksi EBV. Gen litik BRLF1 berperan sebagai mediator transisi dari fase laten menjadi litik. Pengukuran aktivitas mRNA EBV di lokasi tumor primer perlu dilakukan karena lebih mencerminkan patogenesis KNF yang sesungguhnya dari pada diagnosis serologi dan pengukuran DNA EBV di sirkulasi darah. Penelitian ini bertujuan untuk mengetahui nilai ekspresi relatif mRNA BRLF1 Epstein-Barr Virus pada beberapa tingkat stadium tumor penderita KNF sebagai petanda biologi potensial dalam patogenesis KNF. Metode penelitian yang digunakan adalah metode deskriptif yang berbentuk studi seran lintang. Sampel penelitian ini adalah biopsi jaringan tumor dalam blok parafin penderita KNF sebanyak 24 sampel. Sampel tersebut telah didiagnosis pasti sebagai KNF WHO-3 dari hasil pemeriksaan Patologi Anatomi pada Poli Patologi Anatomi, RSUD Prof. Dr. Margono Soekarjo, Purwokerto serta memenuhi kriteria inklusi sampel. Analisis statistik dilakukan untuk membandingkan ekspresi relatif mRNA BRLF1 stadium yang berbeda. Nilai ekspresi relatif mRNA BRLF1 EBV pada 24 sampel KNF berkisar 99,04415959-1097,496026. Hasil analisis statistik menunjukkan nilai ekspresi relatif mRNA BRLF1 EBV pada stadium awal (n = 5; 544,72420 + 142,614733) lebih tinggi 1,8 kali dibandingkan dengan stadium lanjut (n = 17; 395,68612 + 293,172201), namun peningkatan ekspresi relatif mRNA BRLF1 EBV tidak bermakna secara statistik karena didapatkan nilai p=0,130 (p>0,05). Oleh karena itu, ekspresi relatif mRNA BRLF1 EBV dari biopsi jaringan tumor dalam blok parafin tidak berpotensi sebagai petanda biologi molekul patogenesis KNF, khususnya progresivitas tumor pada stadium lanjut KNF.
Kandungan Senyawa Penangkal Sinar Ultra Violet dari Ekstrak Rumput Laut Eucheuma cottonii dan Turbinaria conoides
Authors: Yanuarti Rini , Nurjanah Nurjanah , Anwar Effionora , Pratama Ginanjar 
Published: September 2017

Rumput laut memiliki beberapa aplikasi ekonomi dalam berbagai jenis industri, salah satunya untuk industri kosmetik. Salah satu kosmetik yang banyak digunakan yaitu krim tabir surya. Efektivitas dari krim tabir surya biasanya dinyatakan dengan nilai SPF (sun protection factor). Tujuan dari penelitian ini adalah untuk mengetahui kandungan senyawa aktif dan nilai SPF pada ekstrak rumput laut Turbinaria conoides dan Eucheuma cottonii yang dapat digunakan sebagai bahan aktif pada sediaan krim tabir surya. Hasil pengujian menunjukkan rumput laut Turbinaria conoides mengandung golongan senyawa fenol hidrokuinon, flavonoid, triterpenoid, steroid, dan saponin. Rumput laut Eucheuma cottonii hanya ditemukan senyawa alkaloid. Nilai SPF tertinggi pada rumput laut Turbinaria conoides terdapat pada ekstrak metanol (SPF 16.7), sedangkan untuk rumput laut Eucheuma cottonii terdapat pada ekstrak etil asetat (SPF 8.8). Hasil tersebut memperlihatkan bahwa ekstrak dari rumput laut Turbinaria conoides dan Eucheuma cottonii memiliki potensi yang baik jika digunakan sebagai bahan aktif pada sediaan krim tabir surya.
Profil RAPD Tanaman Kantung Semar Beberapa Koleksi Kebun Raya Baturraden
Authors: Mayangsari Retno , Susanto Agus Hery , Yuniaty Alice 
Published: September 2017

Telah dilakukan penelitian tentang profil RAPD beberapa tanaman kantung semar (Nepenthes spp.) koleksi Kebun Raya Baturraden. Tujuh individu yang dipelajari merupakan spesies semiendemik Gunung Slamet dan endemik Jawa, yaitu N. adrianii dan N. gymnampora. Metode yang digunakan adalah survei dengan teknik pengambilan sampel secara acak. DNA genomik sampel diekstraksi untuk kemudian digunakan sebagai templat dalam amplifikasi marka RAPD menggunakan teknik PCR dengan 10 primer acak, yaitu ES10G23, ES10A26, ES10C24, ES10G33, OPA-2, OPA-9, OPA-13, OPB-3, OPB-5, dan OPB-7. Hasil penelitian menunjukkan bahwa ke-10 primer tersebut menghasilkan 43 (67,2%) pita polimorfik dan 21 (32,8%) pita monomorfik dengan ukuran berkisar dari 130 hingga 1.500 bp. OPA-2 and OPB-3 menghasilkan polimorfisme tertinggi, sedangkan ES10G23 dan OPA-13 menghasilkan pita monomorfik terbanyak. Dendogram yang dikonstruksi menggunakan UPGMA dalam MEGA 6.06 memperlihatkan bahwa dua klaster terbentuk pada jarak genetik 18%. Kedua klaster tersebut cenderung dipisahkan oleh lokasi geografi.