bluuebunny/crossref_metadata_2025_split huggingface dataset:
CADASIL: two new cases with intracerebral hemorrhage
Authors: Zhang Chen , Li Wei , Li Shaowu , Niu Songtao , Wang Xingao , Tang Hefei , Yu Xueying , Chen Bin , Shi Yuzhi , Chen Qihua , Guo Liying , Pan Yunzhu , Wang Yilong , Zhang Zaiqiang 
Published: March 2017

AbstractWhether cerebral autosomal‐dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a risk factor for spontaneous intracerebral hemorrhage (ICH) and influences outcomes remains unclear. In this study, we report two cases of CADASIL presenting with cerebral hemorrhages. These cases suggest that a CADASIL vasculopathy by itself mainly results in ICH, as indicated by slight vascular risk factors and prominent neuroimaging abnormalities, suggesting that CADASIL should be considered a risk factor for ICH. Interestingly, decreased perihematomal edema was noted in ICH patients with CADASIL in this study.
Preparation of a Stable Bicyclic Aziridinium Ion and Its Ring Expansion toward Piperidines and Azepanes
Authors: Choi Jieun , Yadav Nagendra Nath , Ha Hyun‐Joon 
Published: March 2017

AbstractThe formation of the stable form of 1‐azabicyclo[4.1.0]heptane tosylate was successfully achieved from 2‐[4‐tolenesulfonyloxybutyl]aziridine, by stirring in MeCN at room temperature. The ring strain in the three‐membered ring could be released through the cleavage of either C−N bond, but ring opening with various nucleophiles proceeded in a highly regio‐ and stereoselective manner. Two possible pathways, in which the aziridine ring was opened by nucleophilic attack at the bridge and the bridgehead, yielded piperidine and azepane rings, respectively. This selective transformation starting from chiral aziridines constitutes an efficient route for the asymmetric synthesis of biologically important natural products, such as fagomines, febrifugine, sedamine, hydroxypipecolic acid, and balanol.
Monodisperse plum‐like sulfonated PGMA‐DVB microspheres as a new ion exchange resin
Authors: Wei Z. Q. , Wang Z. , Hong R. Y. , Wang Y. F. 
Published: March 2017

ABSTRACTMonodisperse plum‐like crosslinked poly(glycidyl methacrylate‐co‐divinyl benzene) (PGMA‐DVB) microspheres were prepared by dispersion polymerization using glycidyl acrylate as monomer and divinyl benzene as crosslinking agent, and then sulfonated by sulfonation process with phosphorus pentoxide to increase the grafting ratio. The morphology and composition of microspheres were characterized by scanning electron microscope with energy dispersive analysis of X‐rays (SEM‐EDX), Fourier transform infrared spectroscopy (FT‐IR), thermogravimetric analysis (TGA), and BET surface area analyses. The average sizes of PGMA microspheres and PGMA‐DVB microspheres were 2.18 and 2.52 μm, respectively. The effect of DVB content on the properties of microspheres was investigated and the experimental results indicate that the microspheres prepared with DVB content have crinkled surface with large specific surface area, and with the increase of the DVB content, the average size of the microspheres become larger and the particle size distribution become wider. The as‐prepared sulfonated PGMA‐DVB microspheres were used to remove the copper (II) ion in solution and the maximum adsorption capacity was 75.08 mg/g. This work provides an effective but simple method for a controllable preparation of polymer microspheres with rough surface and high specific surface area, and it could be a new kind of ion exchange resin after sulfonation. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44994.
Chemicals isolated from Justicia adhatoda Linn reduce fitness of the mosquito, Aedes aegypti L
Authors: Thanigaivel Annamalai , Senthil‐Nathan Sengottayan , Vasantha‐Srinivasan Prabhakaran , Edwin Edward‐Sam , Ponsankar Athirstam , Selin‐Rani Selvaraj , Pradeepa Venkatraman , Chellappandian Muthiah , Kalaivani Kandaswamy , Abdel‐Megeed Ahmed , Narayanan Raman , Murugan Kadarkarai 
Published: March 2017

AbstractExtracts from Justicia adhatoda L. (Acanthaceae) strongly reduced the fitness of the mosquito, Aedes aegypti Linn. The methanolic extracts inhibited several enzymes responsible for protecting insects from oxidative and other damage, including glutathione‐S‐transferase, superoxide dismutase, cytochrome P450, and α‐ and β‐esterases. They increased repellency (maximum repellency at 100 ppm) in host‐seeking adult females using the “arm‐in cage assay.” Histopathological examination showed the extracts led to serious midgut cell damage. Justicia adhatoda extracts led to reduced fecundity and oviposition of gravid females compared to controls. The extracts led to substantially reduced A. aegypti survival. We infer that the extracts have potential to reduce pathogen transmission by suppressing population growth of A. aegypti, and possibly other mosquito species.
Die INFRABIM‐Reifegradmetrik
Authors: Borrmann André , König Markus , Hochmuth Markus , Liebich Thomas , Elixmann Robert 
Published: March 2017

AbstractDas Bundesministerium für Verkehr und Digitale Infrastruktur (BMVI) beabsichtigt, die Methodik des Building Information Modeling (BIM) ab 2020 regelmäßig für Bauvorhaben in seinem Zuständigkeitsbereich anzuwenden. In Vorbereitung hierauf werden derzeit verschiedene Pilotvorhaben durchgeführt. Um noch bestehende Hürden und Defizite zu identifizieren und daraus Schlussfolgerungen in Hinblick auf zu ergreifende Maßnahmen zu treffen, ist es notwendig, den Umfang und die Qualität des BIM‐Einsatzes in den Pilotprojekten zu messen und zu bewerten. Hierzu wurde von der wissenschaftlichen Begleitung eine Reifegradmetrik entwickelt, die anhand von mehr als 60 Einzelkriterien in zehn Teilbereichen die Tiefe der BIM‐Umsetzung in einem Bauvorhaben detailliert erfasst. Der Artikel stellt die Metrik vor und illustriert ihre Anwendung anhand der vier ersten BIM‐Pilotvorhaben des BMVI.
Affordances and challenges of computational tools for supporting modeling and simulation practices
Authors: Magana Alejandra J. , Falk Michael L. , Vieira Camilo , Reese Michael J. , Alabi Oluwatosin , Patinet Sylvain 
Published: March 2017

ABSTRACTThis mixed‐methods sequential explanatory design investigates disciplinary learning gains when engaging in modeling and simulation processes following a programming or a configuring approach. It also investigates the affordances and challenges that students encountered when engaged in these two approaches to modeling and simulation. © 2017 Wiley Periodicals, Inc. Comput Appl Eng Educ 25:352–375, 2017; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21804
Cyclometalated Iridium‐Complex‐Based Label‐Free Supersandwich Electrogenerated Chemiluminescence Biosensor for the Detection of Micro‐RNA
Authors: Zhao Ying , Yang Xiaolin , Han Danjuan , Qi Honglan , Gao Qiang , Zhang Chengxiao 
Published: March 2017

AbstractThe synthesis and characterization of compounds as electrogenerated chemiluminescence (ECL) reagents are crucial in fundamental research for ECL biosensors. In this work, a new cyclometalated iridium(III) complex, [(bt)2Ir(dmphen)](PF6), was synthesized by using 2‐phenylbenzothiazole (bt) as the
main ligand and 5,6‐dimethyl‐1,10‐phenanthroline (dmphen) as the
ancillary ligand. The photophysical, electrochemical, and ECL properties of this complex were extensively studied in acetonitrile solvent and aqueous solution. This complex displayed yellow‐green photoluminescence with a maximum wavelength at 522 nm, a reversible one‐electron oxidation wave at E1/2=+1.51 V (vs. SCE), and a reversible one‐electron reduction wave at −1.29 V (vs. SCE). Typically, in the annihilation process, the ECL efficiency of this complex was 12 times higher than that of Ru(bpy)32+. More importantly, a highly sensitive ECL method for the determination of micro‐RNA at the sub‐picomolar level was developed on basis of employing this complex as an ECL intercalator and signal amplification by using the supersandwich model. Compared with Ru(phen)3Cl2 and [(bt)2Ir(dcbpy)](PF6), this complex showed a relatively low background and the highest increased ratio as an ECL intercalator in the developed system. The increased ECL intensity was directly proportional to the concentration of the micro‐RNA in the range of 0.1 to 10 pM, with a detection limit of 13 fM. The developed method can effectively discriminate target micro‐RNA122 from two‐base mismatched micro‐RNA122. This work demonstrates that this cyclometalated iridium(III) complex is an effective alternative intercalator for ECL determination of the micro‐RNA. It is expected that this complex will be extended to design various analytical platforms for the detection of diverse analytes such as DNA/RNA, DNAzyme/target, and aptamer/targets.
Fe3N‐Co2N Nanowires Array: A Non‐Noble‐Metal Bifunctional Catalyst Electrode for High‐Performance Glucose Oxidation and H2O2 Reduction toward Non‐Enzymatic Sensing Applications
Authors: Zhou Dan , Cao Xiaoqin , Wang Zao , Hao Shuai , Hou Xiandeng , Qu Fengli , Du Gu , Asiri Abdullah M. , Zheng Chengbin , Sun Xuping 
Published: March 2017

AbstractAmong reported electrode materials, a nanoarray is an attractive architecture for molecular detection because of its large specific surface area and easy accessibility for target molecules. Here, a new Fe3N‐Co2N nanowires array grown on carbon cloth (Fe3N‐Co2N/CC) is reported as a non‐noble‐metal bifunctional catalyst electrode for high‐performance glucose oxidation and H2O2 reduction. As an electrochemical non‐enzymatic sensor for glucose detection, Fe3N‐Co2N/CC shows a fast response time of 8 s, a low detection limit (LOD) of 77 nm (signal/noise=3), and a high sensitivity of 4333.7 μA mm−1 cm−2. As an H2O2 sensor, it shows a LOD of 59 nm (signal/noise=3) and a sensitivity of 2273.8 μA mm−1 cm−2 with a response time of 2 s. In addition, the proposed sensor is stable with high selectivity, specificity, and reproducibility, and its application for real sample analysis has been successfully demonstrated.
Bond Order Analysis, Packing Ratio, and Electronic Structures of Two Structural Polymorphs Based on Manganese Complexes
Authors: Chen Xue‐Li , Zhang Yuexing , Zhang Ming‐Yuan , Zeng Ming‐Hua 
Published: March 2017

AbstractThe bond order and packing ratios in the single‐crystal of the two structural polymorphs as well as the detailed electronic structures of the molecular model were studied using density functional theory. The strength of different Mn coordination bonds was analyzed in detail through Mayer bond order. Besides bond length, many other factors such as the orientation of ligand and nature of metal also significantly influence the bond order. Packing ratios calculated using cluster model reveals that packing along b direction in Dimer is more favorable than other directions due to the associated interactions of π‐π and Cl…H when packing in this direction. Electronic structure helps explain the formation of Dimer from monomer or direct forming of Chain from ligand/Cl and metal. This would shed light on further understanding the importance of supramolecular interaction on crystal engineering.
Real‐world impact of non–breast cancer–specific death on overall survival in resectable breast cancer
Authors: Fu Jianfei , Wu Lunpo , Jiang Mengjie , Li Dan , Jiang Ting , Fu Wei , Wang Liangjing , Du Jinlin 
Published: March 2017

BACKGROUNDThe real‐world occurrence rate of non–breast cancer–specific death (non‐BCSD) and its impact on patients with breast cancer are poorly recognized.METHODSWomen with resectable breast cancer from 1990 to 2007 in the Surveillance, Epidemiology, and End Results database (n = 199,963) were analyzed. The outcome events of breast cancer were classified as breast cancer–specific death (BCSD), non‐BCSD, or survival. Binary logistics was used to estimate the occurrence rates of non‐BCSD and BCSD with different clinicopathological factors. The Gray method was used to measure the cumulative incidence of non‐BCSD and BCSD. The ratio of non‐BCSDs to all causes of death and stacked cumulative incidence function plots were used to present the impact of non‐BCSD on overall survival (OS). Models of Cox proportional hazards regression and competing risk regression were compared to highlight the suitable model.RESULTSThere were 12,879 non‐BCSDs (6.44%) and 28,784 BCSDs (14.39%). The oldest age group (>62 years), black race, and a single or divorced marital status were associated with more non‐BCSDs. With adjustments for age, a hormone receptor–positive (HoR+) status was no longer related to increased non‐BCSDs. In patients with grade 1, stage I disease and an HoR+ status as well as the oldest subgroup, a great dilution of non‐BCSD on all causes of death could be observed, and this led to incorrect interpretations. The inaccuracy, caused by the commonly used Cox proportional hazards model, could be corrected by a competing risk model.CONCLUSIONSOS was largely impaired by non‐BCSD during early breast cancer. For some future clinical trial planning, especially for the oldest patients and those with HoR+ breast cancer, non‐BCSD should be considered a competing risk event. Cancer 2017;123:2432–43. © 2017 American Cancer Society.
A measurement study of device‐to‐device sharing in mobile social networks based on Spark
Authors: Wang Hui , Wang Xiaofei , Li Keqiu , Ren Jianji , Zhang Xiaohong , Jiang Tianpeng 
Published: March 2017

SummaryBecause of the exponential growth of mobile users' demand for multimedia services in recent years, the increasing network traffic load gets a close attention of the mobile network operators. For the mobile traffic explosion issue to be solved, there are many efforts trying to offload the mobile traffic from infrastructure cellular links to direct local short‐range communications among groups of users, which is called device‐to‐device sharing (D2D) in mobile social networks. Although there have been a number of studies for improving the exploitation of friends, contents, and sharing performance, there is no any large‐scale measurement‐based study to analyze the realistic D2D sharing service. We focus on the empirical trace from Xender, a popular mobile application for D2D sharing, and implement an effective big data processing platform based on Spark with customized algorithms. Extensive analysis and discussions are carried out from the perspectives of general time series statistics, content properties, and social graph basics. The trace‐driven analysis exploits a number of implications regarding power law distribution for content popularity disparity, clustering effects of user relationships, and so on. We further discuss the potentials of improving Xender's quality of service and optimizing its system resource, and hopefully, our study can offer useful guidelines for not only Xender but also those growing global social D2D sharing services.
Hardware‐assisted software event tracing
Authors: Vergé Adrien , Ezzati‐Jivan Naser , Dagenais Michel R. 
Published: March 2017

SummaryEvent tracing is a reliable and a low‐intrusiveness method to debug and optimize systems and processes. Low overhead is particularly important in embedded systems where resources and energy consumption is critical. The most advanced tracing infrastructures achieve a very low footprint on the traced software, bringing each tracepoint overhead to less than a microsecond. To reduce this still non‐negligible impact, the use of dedicated hardware resources is promising. In this paper, we propose complementary methods for tracing that rely on hardware modules to assist software tracing. We designed solutions to take advantage of CoreSight STM, CoreSight ETM, and Intel BTS, which are present on most newer ARM‐based systems‐on‐chip and Intel x86 processors. Our results show that the time overhead for tracing can be reduced by up to 10 times when assisted by hardware, as compared to software tracing with LTTng, a high‐performance tracer for Linux. We also propose a modification to the Perf tool to speed BTS execution tracing up to 65%.
Investigating device‐specific visual feedback for cross‐device transfer in table‐centric multisurface environments
Authors: Scott Stacey D. , Besacier Guillaume , Goyal Nippun , Cento Frank 
Published: March 2017

SummaryTable‐centric multisurface environments (T‐MSEs) that combine small multitouch surfaces (eg, smartphones and tablets) with large interactive tabletops provide people with both personal and shared workspaces to support various independent and collective tasks during group activities. This paper reports on the third in a series of studies exploring how existing interaction methods for cross‐device transfer, such as the Pick‐and‐Drop (P&D) method, can be adapted to table‐centric multisurface environment settings. The study examined the use of device‐specific visual feedback to improve users' awareness of transferred content during P&D transfer. The tabletop feedback utilized the existing Surface Ghosts P&D feedback approach (ie, “ghosted” versions of transferred content were displayed in real time under the user's hand). The tablet feedback consisted of a static “Tablet Bridge” feedback showing miniature versions of transferred content along the top edge of the tablet interface. The study found that providing both types of feedback significantly improved users' transfer awareness over providing Surface Ghosts feedback alone. It also revealed that the Tablet Bridge feedback helped compensate for technical and usability issues associated with the Surface Ghosts feedback design. Lessons learned from our combined series of cross‐device transfer studies are reflected upon, and relevant design implications are discussed.
Development of whole-sediment toxicity identification and evaluation (TIE) techniques for two Australian freshwater species: Chironomus tepperi and Austrochiltonia subtenuis
Authors: Mehler W.Tyler , Keough Michael J. , Pettigrove Vincent 
Published: March 2017

Abstract

Most of the public literature and available guidance documents on the conduct of freshwater whole-sediment toxicity identification and evaluations (TIEs) detail the use of test organisms and amending agents that are readily available in North America. These commonly used test organisms and the supported amending agents, however, are not available and largely inappropriate (i.e., not native species) for conducting whole-sediment TIEs outside of North America. The overall objective of the present study was to build foundational methods for performing freshwater whole-sediment TIEs in Australia. We examined the capability of 3 amending agents: ANZ38 Zeolite (for ammonia; Castle Mountain Zeolites), Oxpure 325B-9 Activated Carbon (for nonpolar organics; Oxbow Activated Carbon), and Lewatit MonoPlus TP 207 (for cationic metals; Lanxess Deutschland) on 2 Australian native freshwater species: the midge Chironomus tepperi and the amphipod Austrochiltonia subtenuis. To evaluate the effectiveness of each amendment, bioassays were conducted with spiked sediments of ammonia, permethrin (as part of a commercial formulation), and copper using acute median lethal concentrations (LC50s) for both species and growth median effect concentration (EC50) of midges as the endpoints of interest. Environ Toxicol Chem 2017;36:2476–2484. © 2017 SETAC
GSK1904529A, a Potent IGF‐IR Inhibitor, Reverses MRP1‐Mediated Multidrug Resistance
Authors: Gupta Pranav , Xie Meina , Narayanan Silpa , Wang Yi‐Jun , Wang Xiu‐Qi , Yuan Timothy , Wang Ziyue , Yang Dong‐Hua , Chen Zhe‐Sheng 
Published: March 2017

ABSTRACTOverexpression of multidrug‐resistant efflux transporters is one of the major causes of chemotherapy failure. MRP1, a 190 kDa efflux transporter, confers resistance to a wide of range of chemotherapeutic drugs. Here we study the cellular effects of GSK1904529A in reversing MRP1‐mediated drug resistance. Cytotoxicity of GSK1904529A was determined by MTT assay. Reversal effects of GSK1904529A in combination with MRP1 substrates were determined. The intracellular accumulation and efflux of MRP1 substrate was measured by scintillation counter and protein expression was determined by Western blotting analysis. Cell cycle effects of GSK1904529A in combination with MRP1 substrates were determined by flow cytometric analysis. GSK1904529A, at non‐toxic concentrations, enhanced the cytotoxicity of MRP1 substrates in HEK293/MRP1 cells. Furthermore, GSK1904529A increased the intracellular accumulation of [3H]‐vinblastine by inhibiting the efflux function of MRP1. GSK1904529A did not alter the expression level of MRP1, induced a G0/G1 phase cell cycle arrest. Our results indicated that GSK1904529A significantly increased the sensitivity of MRP1 overexpressing cells to chemotherapeutic agents. Furthermore, GSK1904529A enhanced the efficacy of chemotherapeutic drugs that are substrates of MRP1. J. Cell. Biochem. 118: 3260–3267, 2017. © 2017 Wiley Periodicals, Inc.
Design, Synthesis, and Anticancer Activity of 3H–benzo[f]chromen‐3‐one Derivatives
Authors: Soni Rina , Umar Shweta , Shah Nirav N. , Balkrishnan Suresh , Soman Shubhangi S. 
Published: March 2017

A series of substituted aminomethylbenzocoumarin derivatives 8a–i have been synthesized, characterized, and structure of compound 8g was confirmed by X‐ray single crystal analysis. All the synthesized compounds were tested for their anticancer activity against cancer cell lines A549 (lung carcinoma cell line), MCF7 (breast cancer cell line), and A375 (melanoma cell line). Compounds 8a, 8f, and 8h showed excellent growth inhibitory activity against all three cell lines, respectively. Compounds 8a and 8f were also found to be quite promising at very low concentration as an anticancer agent against MCF7 and A549 cell lines. Compounds 8g and 8i showed excellent antimitotic activity with IC50 0.32 and19.98 nM for A549 cell line.