bluuebunny/crossref_metadata_2025_split huggingface dataset:
Satellite‐Based Surveys Reveal Substantial Methane Point‐Source Emissions in Major Oil & Gas Basins of North America During 2022–2023
Authors: Li Fei , Bai Shengxi , Lin Keer , Feng Chenxi , Sun Shiwei , Zhao Shaohua , Wang Zhongting , Zhou Wei , Zhou Chunyan , Zhang Yongguang 
Published: September 2024

AbstractUtilizing imaging spectroscopy technology to identify methane super‐emitters plays a vital role in mitigating methane emissions in the Oil & Gas (O&G) sector. While earlier research has uncovered significant point‐source methane emissions from O&G production in the US and Canada, which are key regions with large methane emissions, a comprehensive post‐COVID‐19 survey has been notably absent. Here, we perform a detailed survey of methane super‐emitters across multiple basins of North America (Marcellus Shale, Haynesville/Bossier Shale, Permian Basin and Montney Shale) using the new Chinese Gaofen5‐01A/02 (GF5‐01A/02) satellite measurements during 2022–2023. We detect 139 individual methane plumes emanating from 122 point sources, with flux rates ranging from 519 to 16,071 kg hr−1. These emissions exhibit a highly skewed and heavy‐tailed distribution, constituting approximately 23% of the flux inversion with TROPOMI in the sample region, with a range of 13%–40%. Moreover, we observe a 66.7% reduction in methane emissions in Permian Basin during COVID‐19, followed by fluctuations until spring 2023. By summer 2023, methane emissions rebound to twice their previous magnitude (1.68 ± 0.58 Tg a−1). Using these point‐source surveys, we further quantify a regional methane emission of 2.69 ± 0.86 Tg a−1 in Permian Basin. This estimation closely aligns with top‐down inversions (2.22 ± 0.40 Tg a−1) from TROPOMI. The upscale estimation underscores the effectiveness of high‐resolution remote sensing measurements in improving bottom‐up emissions inventories and refining regional methane emission assessments. Our results highlight the potential climate benefits derived from regular monitoring and specific remediation efforts focused on relatively few strong point‐source emissions.
Synchronization of the Recent Decline of East African Long Rains and Northwestern Eurasian Warming
Authors: Hagos Samson , Chang Chuan‐Chieh (Jay) , Ma Po‐Lun , Lubis Sandro W. , Balaguru Karthik , Shi Pengfei , Garuba Oluwayemi , Leung L. Ruby 
Published: September 2024

AbstractThe East African March–April–May (MAM, “long rains”) precipitation decline in recent decades remains a puzzle marked by various proposed large‐scale drivers. Here, the interannual variability of the long rains and their recent drying trend are examined using global model simulations and observations. Comparison of a control simulation and re‐initialized simulations in which land‐surface feedback is suppressed shows that much of the long rains deficit experienced between 1980 and 2014 is synchronized with the warming of the Northwestern Eurasian landmass. In agreement with the modeling results, multiple observational data sets reveal a strong negative correlation between MAM mean East African rainfall amount and the surface temperature over Northwestern Eurasia. Idealized simulations further indicate that warming in Northwestern Eurasia weakens the regional Hadley Cell and diverts the monsoonal transport of moisture away from Eastern Africa toward Europe and southern Africa, highlighting the role of remote land surface warming on the observed precipitation decline.
Simulation of Gas‐Particle Partitioning of Semi‐Volatile n‐Alkanes and PAHs in Nanjing, China, and Denver, United States: Effects of Vapor Pressure and Surface Adsorption Estimation
Authors: Zhou Zhiyan , Wang Zishu , Feng Wei , Qin Chao , Liao Hong , Wang Yuhang , Xie Mingjie 
Published: September 2024

AbstractThe concentration data of semi‐volatile n‐alkanes and PAHs in the gas phase and in PM2.5 were obtained from Nanjing and Denver. First, the gas‐particle partitioning coefficients of the target compounds were calculated and compared with the predictions based on the equilibrium absorptive partitioning theory. Although the vapor pressure (poL) estimation method was selected to improve the agreement between measured and predicted partitioning coefficients, n‐alkanes in Denver and PAHs in both cities exhibited stronger sorption to PM2.5 than predicted. By including the adsorption mechanism, the average logarithms and temporal variations of the partitioning coefficients were well simulated in both Nanjing and Denver. The partitioning of n‐alkanes in Nanjing can be primarily explained by the absorption mechanism, while the adsorption mechanism dominates that for n‐alkanes in Denver and PAHs in both cities. To obtain an optimal simulation, the poL of n‐alkanes and PAHs was estimated using the SPARC and SIMPOL—two group contribution methods, respectively, and the difference between desorption and vaporization enthalpies was set between 2 and 3 kcal mol−1 for n‐alkanes in Denver and PAHs in both cities. Therefore, the estimation of poL and surface adsorption should be carefully considered when parameterizing the gas‐particle partitioning of non‐polar organic compounds in future field and modeling studies.
Airborne Measurements Reveal High Spatiotemporal Variation and the Heavy‐Tail Characteristic of Nitrous Oxide Emissions in Iowa
Authors: Dacic Natasha , Plant Genevieve , Kort Eric A. 
Published: September 2024

AbstractNitrous oxide (N2O) emissions from croplands contribute substantially to the climate impact of agriculture. Emissions of N2O are controlled by both anthropogenic and environmental factors and can vary by orders of magnitude over short times and distances. This nature of emissions is difficult to capture with models and presents an observational challenge. In the 2021 and 2022 growing season, we collected airborne measurements of N2O over Iowa to characterize N2O emissions at the farm to multi‐county spatial scales across days. We link our airborne observations to surface emissions using a Lagrangian particle dispersion model and quantify emissions using a Bayesian inversion framework. We find emissions magnitudes across Iowa, showing greater skew than modeled predictions, with a small fraction of fields contributing disproportionately to the total [25% of the domain contributing to 52%–77% of total emissions]. In addition to the high spatial variation, we find high temporal variability between flight days by a factor of 2 at the 100 km scale, and an order of magnitude at the 2 km scale], with peak emissions occurring at median soil moisture. This work illustrates the importance of transient, intense emissions from concentrated areas in explaining total cropland emissions, and demonstrates how airborne measurements can provide insights into variation that may be missed by other observational systems. Investigation into environmental factors highlights the need for observations, models and their input data to be spatiotemporally resolved to enable direct comparison, facilitating evaluation of predicted and reported emissions and providing guidance and feedback on mitigation strategies.
Substantial Cold Bias During Wintertime Cold Extremes in the Southern Cascadia Region in Historical CMIP6 Simulations
Authors: Rogers M. H. , Mauger G. , Cristea N. 
Published: September 2024

AbstractGlobal climate models often simulate atmospheric conditions incorrectly due to their coarse grid resolution, flaws in their dynamics, and biases resulting from parameterization schemes. Here we document a bias in the magnitude and extent of minimum temperature extremes in the CMIP6 model ensemble, relative to ERA5. The bias is present in the southern Cascadia region (i.e., Pacific Northwestern United States and southwestern British Columbia, Canada, spanning from the coast to the Rocky Mountains), with some models showing a bias magnitude in excess of −10°C in the first percentile of daily winter minimum temperature. The sea level pressure pattern for these events is similar in CMIP6 models and ERA5, showing high anomalies in the Northeast Pacific that are indicative of an atmospheric blocking pattern and consequently more northerly flow. Though this atmospheric blocking pattern is typically concurrent with cold winter temperatures across much of North America, Rocky and Cascade mountain ranges prevent the cold air from reaching the southern Cascadia region as confirmed by the observations and reanalysis. Our results suggest that the bias in CMIP6 minimum temperatures is a result of unresolved topography in the Rockies and Cascade mountain ranges, such that the terrain does not adequately block cold air advection from reaching the southern Cascadia region.
Decadal Relationship Between Arctic SAT and AMOC Changes Modulated by the North Pacific Oscillation
Authors: Zhao Bowen , Lin Pengfei , Liu Hailong , Hu Aixue , Chen Xiaolong , Yang Lu 
Published: September 2024

AbstractThe faster warming for Arctic Ocean surface air temperature (SAT) relative to that at lower latitude is connected with various processes, including local radiation feedback, poleward oceanic and atmospheric heat transport. It is unclear how combinations of different low‐frequency internal climate modes influence Arctic amplification on the decadal timescale. Here, the decadal Arctic SAT variation, its connection with the Atlantic meridional overturning circulation (AMOC) and possible underlying mechanisms, are investigated based on several independent observational proxies, pre‐industrial experiments, and historical large ensembles of two CMIP6 models. Our study suggests that AMOC and Arctic SAT vary in phase on the decadal timescale, whereas this relationship is insignificant at the interannual timescale. Further analysis shows that the AMOC accompanied with cross‐basin oceanic water/heat transport between Atlantic and Arctic would alter air–sea interface exchange over the melting ice regions, and then amplified poleward atmospheric heat and moisture transports. The resulting enhanced downward longwave radiation ultimately warms the Arctic SAT. Additionally, the decadal‐scale North Pacific Oscillation (NPO) can modulate the relationship between AMOC and Arctic SAT by influencing poleward moisture transport and cross‐basin circulation. Specifically, the phase shift of combined NPO and AMOC can contribute 14%–41% covariance relationship between AMOC and Arctic SAT. Our study provides potential sources for predicting the Arctic climate and constraining its uncertainty in future projections.
PreMevE‐MEO: Predicting Ultra‐Relativistic Electrons Using Observations From GPS Satellites
Authors: Feng Yinan , Chen Yue , Lin Youzuo 
Published: September 2024

AbstractUltra‐relativistic electrons with energies greater than or equal to two megaelectron‐volt (MeV) pose a major radiation threat to spaceborne electronics, and thus specifying those highly energetic electrons has a significant meaning to space weather communities. Here we report the latest progress in developing our predictive model for MeV electrons in the outer radiation belt. The new version, primarily driven by electron measurements made along medium‐Earth‐orbits (MEO), is called PREdictive MEV Electron (PreMevE)‐MEO model that nowcasts ultra‐relativistic electron flux distributions across the whole outer belt. Model inputs include >2 MeV electron fluxes observed in MEOs by a fleet of GPS satellites as well as electrons measured by one Los Alamos satellite in the geosynchronous orbit. We developed an innovative Sparse Multi‐Inputs Latent Ensemble NETwork (SmileNet) which combines convolutional neural networks with transformers, and we used long‐term in situ electron data from NASA's Van Allen Probes mission to train, validate, optimize, and test the model. It is shown that PreMevE‐MEO can provide hourly nowcasts with high model performance efficiency and high correlation with observations. This prototype PreMevE‐MEO model demonstrates the feasibility of making high‐fidelity predictions driven by observations from longstanding space infrastructure in MEO, thus has great potential of growing into an invaluable space weather operational warning tool.
Teleneonatal or routine resuscitation in extremely preterm infants: a randomized simulation trial
Authors: Gentle Samuel J. , Trulove Sarah G. , Rockwell Nicholas , Rutledge Chrystal , Gaither Stacy , Norwood Carrie , Wallace Eric , Carlo Waldemar A. , Tofil Nancy M. 
Published: September 2024

Abstract

Objective
Teleneonatology, the use of telemedicine for newborn resuscitation and care, can connect experienced care providers with high-risk deliveries. In a simulated resuscitation, we hypothesized that teleneonatal resuscitation, compared to usual resuscitation, would reduce the no-flow fraction.

Study design
This was a single-center, randomized simulation trial in which pediatric residents were randomized to teleneonatal or routine resuscitation. The primary outcome was no-flow fraction defined as time without chest compressions divided by the time during which the heart rate was <60. Secondary outcomes included corrective modifications of bag-mask ventilation and times to intubation and epinephrine administration.

Results
Fifty-one residents completed the scenario. The no-flow fraction (median [IQR]) was significantly better in the teleneonatal group (0.06[0.05]) compared to the routine resuscitation group (0.07[0.82]); effect (95% CI): −16 (−43 to 0). Participants in the teleneonatal resuscitation group more frequently performed corrective modifications to bag-mask ventilation (60% vs 15%; p < 0.001). Time to intubation (214 s vs 230 s; p = 0.58) and epinephrine (395 s vs 444 s; p = 0.21) were comparable between groups.

Conclusions
In this randomized simulation trial of neonatal resuscitation, teleneonatal resuscitation reduced adverse delivery outcomes compared to routine care. Further in hospital evaluation of teleneonatology may substantiate this technology’s impact on delivery outcomes.

ClinicalTrials.gov ID
NCT04258722

Impact

Whereas telemedicine-supported neonatal resuscitation may improve the quality of resuscitation within hospital settings, unique challenges include the need for real-time, high-fidelity audio-video communication with a low failure rate.

The no-flow fraction, which evaluates the quality of chest compressions when indicated, has been associated with survival in other clinical contexts. We report a reduction in no-flow fraction in neonatal resuscitations supported with telemedicine, in addition to improvements in the quality of neonatal resuscitation.

Telemedicine-supported neonatal resuscitation may improve the quality of resuscitation within hospital settings without direct access to neonatologists.
Amyloid precursor protein as a fibrosis marker in infants with biliary atresia
Authors: Kamp Jan C. , Madadi-Sanjani Omid , Uecker Marie , Werlein Christopher , Neubert Lavinia , Kübler Joachim F. , Obed Mikal , Junge Norman , Welte Tobias , Ruwisch Jannik , Jonigk Danny D. , Stolk Jan , Vieten Gertrud , Janciauskiene Sabina 
Published: September 2024

Abstract
Background
Biliary atresia (BA) is a rare condition of unknown origin in newborns with jaundice. In BA bile ducts are non-functional, causing neonatal cholestasis and following liver fibrosis and failure.

Methods
This retrospective study included liver biopsies of 14 infants with BA aged [mean ± SD] 63 ± 23 days. Patients were grouped according to the clinical course (jaundice-free vs recurrent jaundice vs required liver transplantation or liver fibrosis (Ishak fibrosis score)) and followed for 1.61–5.64 years (mean 4.03). Transcriptome profiles were assessed using a panel of 768 fibrosis-specific genes, reanalyzed via qRT-PCR, and confirmed via immunostaining. Plasma from an additional 30 BA infants and 10 age-matched controls were used for amyloid precursor protein (APP) quantification by ELISA.

Results
Different clinical outcome groups showed a homogeneous mRNA expression. Altered amyloid-metabolism-related gene expression was found between cases with Ishak fibrosis score greater than 4. Immunostaining confirmed a distinct presence of APP in the livers of all BA subjects. APP plasma levels were higher in BA than in age-matched controls and correlated with the histological fibrosis grade.

Conclusions
These results suggest that amyloidosis may contribute to BA and liver fibrosis, indicating that APP could serve as a potential liquid biomarker for these conditions.

Impact

Biliary atresia patients with higher fibrosis scores according to Ishak have higher hepatic expression of amyloid-related genes while amyloid precursor protein accumulates in the liver and increases in the circulation.

After a recent study revealed beta-amyloid deposition as a mechanism potentially involved in biliary atresia, we were able to correlate amyloid-metabolism-related transcript levels as well as amyloid precursor protein tissue and plasma levels with the degree of hepatic fibrosis.

These findings suggest that amyloid precursor protein is a fibrosis marker in infants with biliary atresia, reinforcing the role of amyloid metabolism in the pathogenesis of this serious disease.
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity
Authors: Lian Cheng , Zhang Chunyi , Tian Pan , Tan Qilong , Wei Yu , Wang Zixian , Zhang Qin , Zhang Qixiang , Zhong Mengjie , Zhou Li-Quan , Ke Xisong , Zhang Huabing , Zhu Yao , Li Zhenfei , Cheng Jingdong , Wei Gong-Hong 
Published: September 2024

AbstractEpigenetic readers frequently affect gene regulation, correlate with disease prognosis, and hold significant potential as therapeutic targets for cancer. Zinc finger MYND-type containing 11 (ZMYND11) is notably recognized for reading the epigenetic marker H3.3K36me3; however, its broader functions and mechanisms of action in cancer remain underexplored. Here, we report that ZMYND11 downregulation is prevalent across various cancers and profoundly correlates with poorer outcomes in prostate cancer patients. Depletion of ZMYND11 promotes tumor cell growth, migration, and invasion in vitro, as well as tumor formation and metastasis in vivo. Mechanistically, we discover that ZMYND11 exhibits tumor suppressive roles by recognizing arginine-194-methylated HNRNPA1 dependent on its MYND domain, thereby retaining HNRNPA1 in the nucleus and preventing the formation of stress granules in the cytoplasm. Furthermore, ZMYND11 counteracts the HNRNPA1-driven increase in the PKM2/PKM1 ratio, thus mitigating the aggressive tumor phenotype promoted by PKM2. Remarkably, ZMYND11 recognition of HNRNPA1 can be disrupted by pharmaceutical inhibition of the arginine methyltransferase PRMT5. Tumors with low ZMYND11 expression show sensitivity to PRMT5 inhibitors. Taken together, our findings uncover a previously unexplored noncanonical role of ZMYND11 as a nonhistone methylation reader and underscore the critical importance of arginine methylation in the ZMYND11-HNRNPA1 interaction for restraining tumor progression, thereby proposing novel therapeutic targets and potential biomarkers for cancer treatment.
SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis
Authors: Murga Matilde , Lopez-Pernas Gema , Soliva Robert , Fueyo-Marcos Elena , Amor Corina , Faustino Ignacio , Serna Marina , Serrano Alicia G. , Díaz Lucía , Martínez Sonia , Blanco-Aparicio Carmen , Antón Marta Elena , Seashore-Ludlow Brinton , Pastor Joaquín , Jafari Rozbeh , Lafarga Miguel , Llorca Oscar , Orozco Modesto , Fernández-Capetillo Oscar 
Published: September 2024

AbstractSETD8 is a methyltransferase that is overexpressed in several cancers, which monomethylates H4K20 as well as other non-histone targets such as PCNA or p53. We here report novel SETD8 inhibitors, which were discovered while trying to identify chemicals that prevent 53BP1 foci formation, an event mediated by H4K20 methylation. Consistent with previous reports, SETD8 inhibitors induce p53 expression, although they are equally toxic for p53 proficient or deficient cells. Thermal stability proteomics revealed that the compounds had a particular impact on nucleoli, which was confirmed by fluorescent and electron microscopy. Similarly, Setd8 deletion generated nucleolar stress and impaired ribosome biogenesis, supporting that this was an on-target effect of SETD8 inhibitors. Furthermore, a genome-wide CRISPR screen identified an enrichment of nucleolar factors among those modulating the toxicity of SETD8 inhibitors. Accordingly, the toxicity of SETD8 inhibition correlated with MYC or mTOR activity, key regulators of ribosome biogenesis. Together, our study provides a new class of SETD8 inhibitors and a novel biomarker to identify tumors most likely to respond to this therapy.
Chromosome segregation of human nonhomologous Robertsonian translocations: insights from preimplantation genetic testing
Authors: Benn Peter , Merrion Katrina 
Published: September 2024

AbstractRobertsonian translocations (robs) are associated with a high risk for unbalanced segregations. Preimplantation Genetic Testing (PGT) offers an early opportunity to evaluate segregation patterns and selection against chromosome imbalances. The objective of this study was to evaluate the chromosome complements in blastocysts for male and female rob carriers and provide information useful in PGT counseling for rob carriers. PGT results were reviewed for 296 couples where a balanced and nonhomologous rob was present in one member of the couple. All embryos had day 5/6 trophectoderm biopsy and SNP-based PGT. The study included 2235 blastocysts, of which 2151 (96.2%) had results. Significantly fewer blastocysts were available for female rob carriers (mean 4.60/IVF cycle) compared to males (5.49/cycle). Male carriers were more likely to have blastocysts with a normal/balanced chromosome complement; 84.8% versus 62.8% (P < 0.00001). Male carriers had fewer blastocysts with monosomy (60/152, 39.5%) compared to female carriers (218/396, 55.1%) (P = 0.001). Twenty-one (1%) blastocysts showed 3:0 segregation; these were mostly double trisomies and derived from female carriers. Differences between chromosome complements for male versus female carriers suggest that selection against unbalanced forms may occur during spermatogenesis. Six blastocyst samples showed an unexpected (“noncanonical”) combination of trisomy and monosomy. One case of uniparental disomy was identified. For female carriers, there was no association between unbalanced segregation and parental age but for male carriers, there was an inverse association. PGT is a highly beneficial option for rob carriers and patients can be counseled using our estimates for the chance of at least one normal/balanced embryo.
An atomically controlled insulator-to-metal transition in iridate/manganite heterostructures
Authors: Men Enyang , Li Deyang , Zhang Haiyang , Chen Jingxin , Qiao Zhihan , Wei Long , Wang Zhaosheng , Xi Chuanying , Song Dongsheng , Li Yuhan , Jeen Hyoungjeen , Chen Kai , Zhu Hong , Hao Lin 
Published: September 2024

Abstract
All-insulator heterostructures with an emerging metallicity are at the forefront of material science, which typically contain at least one band insulator while it is not necessary to be. Here we show emergent phenomena in a series of all-correlated-insulator heterostructures that composed of insulating CaIrO3 and insulating La0.67Sr0.33MnO3. We observed an intriguing insulator-to-metal transition, that depends delicately on the thickness of the iridate component. The simultaneous enhancements of magnetization, electric conductivity, and magnetoresistance effect indicate a percolation-type nature of the insulator-to-metal transition, with the percolation threshold can be reached at an exceptionally low volume fraction of the iridate. Such a drastic transition is induced by an interfacial charge transfer, which interestingly alters the electronic and crystalline structures of the bulk region rather than the limited ultrathin interface. We further showcased the central role of effective correlation in modulating the insulator-to-metal transition, by demonstrating that the critical thickness of iridate for triggering the metallic state can be systematically reduced down to a single unit-cell layer.