Symptoms Six Weeks After COVID-19 Are Reduced Among US Health Care Personnel Receiving Additional Vaccine Doses During the Omicron Period, December 2021–April 2022
Authors: Mohr Nicholas M , Plumb Ian D , Santos León Eliezer , Pinckney Malea , Harland Karisa K , Krishnadasan Anusha , Hoth Karin F , Rwamwejo Fernand , Haran John P , Briggs-Hagen Melissa , Kontowicz Eric , Talan David A ,   for the Project PREVENT Network, Krispin Sydney , Schuette Allison , Tozloski Jillian , O’Brian Lili , McCormick Laura , Hopcia Karen , Orechia Theresa M , Hill Alexander B , Donohoe Gabrielle , Johnsky Lily R , Fofi Jordyn M , Miyawaki Steven E , Kaithamattam Jenson J , Chung Michelle , Umale Nikita A , Hasdianda Mohammad Adrian , Jambaulikar Guruprasad , Teymour Tala , Davila Maria , Fernandez Suzette , Krebs Elizabeth , Tiao Joshua , Wisniewski Stacey , Bernadas-Hunt Gaynell , Vandeerlin Alexander , Bett Domnic , Leggio Cathryn , Henderson Alexandria , Padilla Reynaldo , Delgado Cynthia , Manahan Madeleine , Hacopian Susana , Yu Vincent E , Potts Melanie , Kuo Jessica , Fowlds Alyssa , Choxom Lidia , Dakos Amy , Tritt Denise , Speight Zoe , Kemble Laurie , Beckham Danielle , Hermanns Cecile , Green Geneatra , Marrs Rachel , Schneider Katherine , Fairfield Catherine , Landers Shannon , Santos Eliezer , Kramer Nathan R , Ullrich Fred , Mangolds Virginia , Nelson Morgan , Lopes Abigail , Galbraith James , Solis Lucia , Peacock Rebekah , Jones Alan , Navalkele Bhagyashri , Vann Savannah , Kile Alexander , Rodgers Joel , Patkar Nivedita , Tidwell-Hand Delissa , Covington Whitney , Kurz Michael C , Poerzgen Peter , Fuentes Megan , Anderson Layla A , Steinbock Kyle A , Zelikoff Alison , Lynch John B , Smith Jennifer , Abedi Glen R , Nyanseor Sankan , Watts Christopher K , Gist Jade James , Saydah Sharon , McCullough Matthew , Krebs Elizabeth , Smithline Howard A , Hou Peter C , Lee Lilly C , Lim Stephen C , Moran Gregory J , Steele Mark T , Beiser David G , Faine Brett , Nandi Utsav , Schrading Walter A , Chinnock Brian , Chipman Anne , Crider Christine D , LoVecchio Frank , Horcher Alysia , Wallace Kelli , Uribe Lisandra , Pathmarajah Kavitha , Girardin Abigail L , Hashimoto Dean M , Bahamon Monica , St. Romain Michelle , Kean Efrat , Mankoff Zachary , Stubbs Amy , Roy Sara , Volturo Gregory , Higgins Amanda , Galbraith James , Crosby James C , Mulrow Mary , Gonzalez Eva , Vakkalanka J Priyanka 
Published: September 2024

Abstract

Background
The objective of this study was to test the hypothesis that subsequent doses of the coronavirus disease 2019 (COVID-19) vaccine are associated with lower incidence of COVID-19-like symptoms at 6 weeks after infection.

Methods
This study was a case–control analysis of health care personnel in an ongoing multicenter COVID-19 vaccine effectiveness study. We enrolled participants at the time of COVID-19-like symptoms between December 19, 2021, and April 27, 2022, which corresponded to the early Omicron-predominant period after original monovalent severe acute respiratory syndrome coronavirus 2 additional vaccination doses became available. Our outcome was self-reported symptoms completed 6 weeks after the onset of symptoms.

Results
We enrolled 2478 participants, of whom 1422 (57%) had COVID-19. The prevalence of symptoms at 6 weeks was 26% (n = 373) in those with COVID-19 and 18% (n = 195) in those without COVID-19. Fatigue (11%) and difficulty sleeping (7%) were most strongly associated with COVID-19. A total of 1643 (66%) participants received a subsequent vaccine dose (after the primary series). Participants with COVID-19 who had received a subsequent vaccination had lower odds of symptoms at 6 weeks (adjusted odds ratio [aOR], 0.55; 95% CI, 0.43–0.70), but this relationship was not observed in those without COVID-19 (aOR, 0.87; 95% CI, 0.59–1.29).

Conclusions
Health care personnel who received subsequent doses of original monovalent COVID-19 vaccine had a lower prevalence of symptoms at 6 weeks than those that did not.