bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplicabilidade do algoritmo de levenberg-marquardt para análise de geração de energia elétrica de um sistema fotovoltaico
Authors: Pinheiro Elisangela , Ruther Ricardo , Lovato Adalberto 
Published: December 2017

Este trabalho avalia o uso de redes neurais artificiais para análise de geração de eletricidade para um sistema fotovoltaico conectado a rede. Inicialmente, são descritas as características e potencial matemático de tratamento de dados apresentados pelas redes. Em seguida, são testadas várias configurações com o objetivo de buscar a mais adequada ao caso. Foram utilizados dados de 2014 da geração de energia, de temperatura ambiente, de temperatura dos módulos da incidência de radiação solar e da hora do dia. A aplicação utilizou os algoritmos de Levenberg-Marquardt para obtenção dos parâmetros da rede e o critério do erro médio quadrado para medir o desempenho. O treinamento foi reealizado com 5, 10, 15, 20, 25, 30 e 60 neurônios na camada oculta. As funções de transferência foram logsigmoide e purelin. O melhor resultado foi realizado foi obtido com 25 neurônios, com coeficiente de correlação de 0,98.
Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies
Authors: Rockenstein Edward , Ostroff Gary , Dikengil Fusun , Rus Florentina , Mante Michael , Florio Jazmin , Adame Anthony , Trinh Ivy , Kim Changyoun , Overk Cassia , Masliah Eliezer , Rissman Robert A. 
Published: December 2017

Dementia with Lewy bodies, Parkinson's disease, and Multiple System Atrophy are age-related neurodegenerative disorders characterized by progressive accumulation of α-synuclein (α-syn) and jointly termed synucleinopathies. Currently, no disease-modifying treatments are available for these disorders. Previous preclinical studies demonstrate that active and passive immunizations targeting α-syn partially ameliorate behavioral deficits and α-syn accumulation; however, it is unknown whether combining humoral and cellular immunization might act synergistically to reduce inflammation and improve microglial-mediated α-syn clearance. Since combined delivery of antigen plus rapamycin (RAP) in nanoparticles is known to induce antigen-specific regulatory T cells (Tregs), we adapted this approach to α-syn using the antigen-presenting cell-targeting glucan microparticle (GP) vaccine delivery system. PDGF-α-syn transgenic (tg) male and female mice were immunized with GP-alone, GP-α-syn (active humoral immunization), GP+RAP, or GP+RAP/α-syn (combined active humoral and Treg) and analyzed using neuropathological and biochemical markers. Active immunization resulted in higher serological total IgG, IgG1, and IgG2a anti-α-syn levels. Compared with mice immunized with GP-alone or GP-α-syn, mice vaccinated with GP+RAP or GP+RAP/α-syn displayed increased numbers of CD25-, FoxP3-, and CD4-positive cells in the CNS. GP-α-syn or GP+RAP/α-syn immunizations resulted in a 30–45% reduction in α-syn accumulation, neuroinflammation, and neurodegeneration. Mice immunized with GP+RAP/α-syn further rescued neurons and reduced neuroinflammation. Levels of TGF-β1 were increased with GP+RAP/α-syn immunization, while levels of TNF-α and IL-6 were reduced. We conclude that the observed effects of GP+RAP/α-syn immunization support the hypothesis that cellular immunization may enhance the effects of active immunotherapy for the treatment of synucleinopathies.SIGNIFICANCE STATEMENTWe show that a novel vaccination modality combining an antigen-presenting cell-targeting glucan particle (GP) vaccine delivery system with encapsulated antigen (α-synuclein) + rapamycin (RAP) induced both strong anti-α-synuclein antibody titers and regulatory T cells (Tregs). This vaccine, collectively termed GP+RAP/α-syn, is capable of triggering neuroprotective Treg responses in synucleinopathy models, and the combined vaccine is more effective than the humoral or cellular immunization alone. Together, these results support the further development of this multifunctional vaccine approach for the treatment of synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple systems atrophy.
Imagen mental y personalidad en equipos de trabajo de estudiantes universitarios
Authors: Lado Campelo Mario Antonio , Pena Adolfo 
Published: December 2017

El objetivo del estudio es describir con imágenes mentales la personalidad de los integrantes de equipos de trabajo y conocer la influencia de variables demográficas. Recientes meta-análisis mostraron que la Conciencia, perteneciente al modelo de los cinco factores de personalidad, es un buen predictor del desempeño académico. Existe escasa literatura acerca de la imagen mental como proceso mental para describir el perfil de personalidad. 226 estudiantes de Grado participaron en el estudio y los resultados indicaron que los adjetivos relacionados con Conciencia y Amigabilidad eran los más frecuentes. No existen diferencias significativas en las variables demográficas, excepto la variable del género.
Carácter emprendedor en estudiantes universitarios: variables demográficas y estrés académico.
Authors: Lado Campelo Mario Antonio , Rouco Sara 
Published: December 2017

El objeto del estudio era conocer la influencia de variables demográficas sobre el carácter emprendedor y conocer su relación con el estrés académico. Existe abundante literatura acerca del perfil del emprendedor y su disposición a involucrarse en proyectos complejos; sin embargo, escasean estudios que relacionen el estrés académico con el carácter emprendedor. 336 estudiantes universitarios de diversos Grados participaron en este estudio. Los resultados indicaron que existen diferencias en el carácter emprendedor en función de la edad y del curso; además, los resultados indicaron que carácter emprendedor y estrés académico son dos variables inversas aunque con correlaciones bajas o moderadas.
A educação artística no trilho de uma nova cidadania
Authors: Oliveira Mónica 
Published: December 2017

O artigo resulta de um projeto de investigação centrado na necessidade de equacionar a educação artística, mais concretamente a arte contemporânea, na promoção de uma cultura de cidadania no 1.º Ciclo do Ensino Básico (1.º CEB). Este trabalho privilegia uma investigação qualitativa e foi ao encontro dos seguintes objetivos: implementar um conjunto de atividades pedagógicas assentes na arte contemporânea no 1.º CEB e compreender o seu impacto na aprendizagem dos alunos e na prática profissional dos professores. As conclusões emergentes do estudo evidenciam a importância da arte contemporânea no desenvolvimento de competências que visam a construção de uma cidadania ativa.Palavras-chave: educação artística, arte contemporânea, cidadania, 1.º ciclo do ensino básico.
Centro Juvenil de Artes Plásticas: contribuindo na formação do cidadão
Authors: Russo Debora Maria 
Published: December 2017

O ser humano vem transformando o mundo e é inerente ao homem a necessidade da representação de suas ações, descobertas e ideias através da arte e do que ela simboliza. A criança vivencia este contexto em seu cotidiano, ainda que a arte promovida pelo adulto, exceda seu entendimento estético. O Centro Juvenil de Artes Plásticas, idealizado pelo artista e educador Guido Viaro propõe, em uma vertente diferenciada, o ensino da arte que tenha nos seus elementos formais a similaridade com aquela que exerce influências estéticas na criança, porém, através de uma prática e um discurso adequado e de fácil entendimento.
Infectious helminth ova in wastewater and sludge: A review on public health issues and current quantification practices
Authors: Gyawali P. 
Published: December 2017

AbstractRaw and partially treated wastewater has been widely used to maintain the global water demand. Presence of viable helminth ova and larvae in the wastewater raised significant public health concern especially when used for agriculture and aquaculture. Depending on the prevalence of helminth infections in communities, up to 1.0 × 103 ova/larvae can be presented per litre of wastewater and 4 gm (dry weight) of sludge. Multi-barrier approaches including pathogen reduction, risk assessment, and exposure reduction have been suggested by health regulators to minimise the potential health risk. However, with a lack of a sensitive and specific method for the quantitative detection of viable helminth ova from wastewater, an accurate health risk assessment is difficult to achieve. As a result, helminth infections are difficult to control from the communities despite two decades of global effort (mass drug administration). Molecular methods can be more sensitive and specific than currently adapted culture-based and vital stain methods. The molecular methods, however, required more and thorough investigation for its ability with accurate quantification of viable helminth ova/larvae from wastewater and sludge samples. Understanding different cell stages and corresponding gene copy numbers is pivotal for accurate quantification of helminth ova/larvae in wastewater samples. Identifying specific genetic markers including protein, lipid, and metabolites using multiomics approach could be utilized for cheap, rapid, sensitive, specific and point of care detection tools for helminth ova and larva in the wastewater.
Conceptos teóricos fundamentales en la revisión de traducciones y su reflejo en el Manual de revisión de la DGT y en las normas ISO 17100:2015 y EN 15038:2006
Authors: Parra-Galiano Silvia 
Published: December 2017

La publicación de la norma ISO 17100:2015, en mayo de 2015, ha vuelto a poner de manifiesto la importancia de diversos aspectos relacionados con la revisión como procedimiento para el aseguramiento de la calidad (AC) de la traducción. En este trabajo se definirán varios conceptos teóricos fundamentales en la revisión de traducciones y se ilustrará su reflejo en las normas ISO 17100:2015 y EN 15038:2006, así como en el Manual de revisión del Departamento de Lengua Española de la Dirección General de Traducción (DGT) de la Comisión Europa. Las fuentes utilizadas para exponer los conceptos teóricos son las monografías y manuales clásicos sobre la revisión (Hosington y Horguelin, 1980; Horguelin, 1985; Horguelin y Brunette, 1998; y Mossop, 2001), los trabajos más recientes de varios investigadores y los realizados por la autora de este trabajo.
Associations of patient characteristics, disease stage, and biopsy technique with the diagnostic quality of core needle renal biopsy specimens from dogs with suspected kidney disease
Authors: Crivellenti Leandro Z. , Cianciolo Rachel , Wittum Thomas , Lees George E. , Adin Christopher A. 
Published: December 2017

Abstract
OBJECTIVE To identify factors affecting the diagnostic quality of core needle renal biopsy specimens from dogs with suspected kidney disease.
DESIGN Cross-sectional study.
ANIMALS 522 client-owned dogs with suspected kidney disease for which core needle renal biopsy specimens (n = 1,089) were submitted to the International Veterinary Renal Pathology Service for evaluation and inclusion in their database.
PROCEDURES Data regarding dog signalment, clinical variables, biopsy method, needle brand and gauge, biopsy results, and other variables were extracted from the database. Variables were tested for association with 3 outcomes of light microscopic evaluation of core specimens: number of glomeruli per core specimen, obtainment of < 10 glomeruli, and presence or absence of renal medullary tissue.
RESULTS Number of glomeruli per core specimen was significantly associated with needle gauge, dog age, serum creatinine concentration, and degree of proteinuria, whereas biopsy method and submitting hospital were significantly associated with the presence of renal medullary tissue in specimens. Mean numbers of glomeruli per core specimen obtained with 14- or 16-gauge needles were similar, but both were significantly greater than the mean number obtained with 18-gauge needles. Needle gauge had a similar association with the likelihood of obtaining < 10 glomeruli in a core specimen. Specimens obtained via laparotomy or laparoscopic approaches more commonly contained medullary tissue than those obtained by ultrasound-guided approaches.
CONCLUSIONS AND CLINICAL RELEVANCE Overall, findings suggested that ultrasound-guided biopsy with a 16-gauge needle should maximize the diagnostic quality of renal biopsy specimens from dogs with suspected kidney disease, while avoiding potential adverse effects caused by larger needles.
Safety and efficacy of intralesional triamcinolone administration for treatment of mast cell tumors in dogs: 23 cases (2005–2011)
Authors: Case Ashley , Burgess Kristine 
Published: December 2017

Abstract
OBJECTIVE To evaluate the safety and efficacy of intralesional triamcinolone administration, as a sole or adjuvant treatment, in dogs with mast cell tumors.
DESIGN Retrospective case series
ANIMALS 23 dogs with mast cell tumors.
PROCEDURES Medical records of dogs treated for a confirmed diagnosis of a mast cell tumor between 2005 and 2011 were reviewed. Patients with a confirmed diagnosis and measurable disease (tumor longest dimension ≥ 0.5 cm) that had received ≥ 1 intralesional treatment with triamcinolone, regardless of prior, concurrent, or adjuvant treatments, were eligible for inclusion. Data collected included patient characteristics, results of cytologic and histologic testing and tumor staging, triamcinolone dosage, treatment response, and adverse events.
RESULTS 23 dogs with 24 tumors were included. Tumors were treated by means of intralesional triamcinolone administration alone (n = 5), intralesional triamcinolone administration with concurrent oral administration of glucocorticoids (6), and intralesional triamcinolone administration with concurrent cytotoxic chemotherapy, with or without oral administration of corticosteroids and radiation therapy (13). Of 5 dogs treated with intralesional triamcinolone administration alone, 1 achieved a complete response, 3 achieved a partial response, and 1 maintained stable disease. The response rate for all 24 tumors (23 dogs) was 67% (16/24), including 4 with a complete response and 12 with a partial response. The median time to progression was 63 days (range, 6 to 447 days). Three dogs experienced adverse events (local hemorrhage [n = 1]; suspected gastrointestinal ulceration [2]).
CONCLUSIONS AND CLINICAL RELEVANCE Intralesional triamcinolone administration may be well tolerated and effective for treatment of nonresectable mast cell tumors in dogs.
Endoscopic transorbital superior eyelid approach: anatomical study from a neurosurgical perspective
Authors: Di Somma Alberto , Andaluz Norberto , Cavallo Luigi Maria , de Notaris Matteo , Dallan Iacopo , Solari Domenico , Zimmer Lee A. , Keller Jeffrey T. , Zuccarello Mario , Prats-Galino Alberto , Cappabianca Paolo 
Published: December 2017

OBJECTIVERecent studies have proposed the superior eyelid endoscopic transorbital approach as a new minimally invasive route to access orbital lesions, mostly in otolaryngology and maxillofacial surgeries. The authors undertook this anatomical study in order to contribute a neurosurgical perspective, exploring the anterior and middle cranial fossa areas through this purely endoscopic transorbital trajectory.METHODSAnatomical dissections were performed in 10 human cadaveric heads (20 sides) using 0° and 30° endoscopes. A step-by-step description of the superior eyelid transorbital endoscopic route and surgically oriented classification are provided.RESULTSThe authors’ cadaveric prosection of this approach defined 3 modular routes that could be combined. Two corridors using bone removal lateral to the superior and inferior orbital fissures exposed the middle and anterior cranial fossa (lateral orbital corridors to the anterior and middle cranial base) to unveil the temporal pole region, lateral wall of the cavernous sinus, middle cranial fossa floor, and frontobasal area (i.e., orbital and recti gyri of the frontal lobe). Combined, these 2 corridors exposed the lateral aspect of the lesser sphenoid wing with the Sylvian region (combined lateral orbital corridor to the anterior and middle cranial fossa, with lesser sphenoid wing removal). The medial corridor, with extension of bone removal medially to the superior and inferior orbital fissure, afforded exposure of the opticocarotid area (medial orbital corridor to the opticocarotid area).CONCLUSIONSAlong with its minimally invasive nature, the superior eyelid transorbital approach allows good visualization and manipulation of anatomical structures mainly located in the anterior and middle cranial fossae (i.e., lateral to the superior and inferior orbital fissures). The visualization and management of the opticocarotid region medial to the superior orbital fissure are more complex. Further studies are needed to prove clinical applications of this relatively novel surgical pathway.
Stereotactic EEG via multiple single-path omnidirectional trajectories within a single platform: institutional experience with a novel technique
Authors: Dewan Michael C. , Shults Robert , Hale Andrew T. , Sukul Vishad , Englot Dario J. , Konrad Peter , Yu Hong , Neimat Joseph S. , Rodriguez William , Dawant Benoit M. , Pallavaram Srivatsan , Naftel Robert P. 
Published: December 2017

OBJECTIVEStereotactic electroencephalography (SEEG) is being used with increasing frequency to interrogate subcortical, cortical, and multifocal epileptic foci. The authors describe a novel technique for SEEG in patients with suspected epileptic foci refractory to medical management.METHODSIn the authors’ technique, standard epilepsy evaluation and neuroimaging are used to create a hypothesis-driven SEEG plan, which informs the 3D printing of a novel single-path, multiple-trajectory, omnidirectional platform. Following skull-anchor platform fixation, electrodes are sequentially inserted according to the preoperative plan. The authors describe their surgical experience and technique based on a review of all cases, adult and pediatric, in which patients underwent invasive epilepsy monitoring via SEEG during an 18-month period at Vanderbilt University Medical Center. Platform and anatomical variables influencing localization error were evaluated using multivariate linear regression.RESULTSUsing this novel technology, 137 electrodes were inserted in 15 patients with focal epilepsy with favorable recording results and no clinical complications. The mean entry point localization error was 1.42 mm (SD 0.98 mm), and the mean target point localization error was 3.36 mm (SD 2.68 mm). Platform distance, electrode trajectory angle, and intracranial distance, but not skull thickness, were independently associated with localization error.CONCLUSIONSThe multiple-trajectory, single-path, omnidirectional platform offers satisfactory accuracy and favorable clinical results, while avoiding cumbersome frames and prohibitive up-front costs associated with other SEEG technologies.
Transdural approach to resection of retro-odontoid cysts in elderly patients: report of 3 cases
Authors: Madhavan Karthik , Chieng Lee Onn , Gaynor Brandon G. , Levi Allan D. 
Published: December 2017

Retro-odontoid cysts that arise from the tectorial membrane are uncommon lesions that can occur in elderly patients. They arise secondary to degenerative changes, including calcium pyrophosphate deposition within the ligaments. Surgical treatment is indicated when these lesions result in intractable pain, instability, and/or myelopathy. Several surgical techniques to treat this condition exist, but the optimal approach in elderly patients with comorbidities remains controversial. Here, the authors present a case series of 3 patients who underwent successful resection of a retro-odontoid lesion performed through a transdural approach.The patients were 70, 81, and 74 years old and presented with symptoms of cervical myelopathy. In consideration of their advanced age and the location of their lesion, resection via a posterior approach was considered. A 1- to 2-cm suboccipital craniectomy and C-1 and partial C-2 laminectomy were performed. These lesions could not be accessed via an extradural posterolateral approach, and so a transdural approach was performed. In the first 2 patients, a preexisting deformity prompted an instrumented fusion. In the third patient, only a lesion resection was performed. In each case, the dural opening was made using a paramedian ipsilateral-sided incision, and the lesion was resected through an incision in the anterior dura mater. Only the posterior dura was closed primarily. MR imaging evidence of excellent spinal cord decompression was evident in follow-up examinations.Transdural resection of retro-odontoid cysts is a viable option for treating asymmetrical ventral extradural cysts. Results from this case series suggest that such an approach is safe and feasible and can provide an alternative to open or endoscopic anterior transpharyngeal approaches.
Endoscopic third ventriculostomy and choroid plexus cauterization in infant hydrocephalus: a prospective study by the Hydrocephalus Clinical Research Network
Authors: Kulkarni Abhaya V. , Riva-Cambrin Jay , Rozzelle Curtis J. , Naftel Robert P. , Alvey Jessica S. , Reeder Ron W. , Holubkov Richard , Browd Samuel R. , Cochrane D. Douglas , Limbrick David D. , Simon Tamara D. , Tamber Mandeep , Wellons John C. , Whitehead William E. , Kestle John R. W. 
Published: December 2017

OBJECTIVEHigh-quality data comparing endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) to shunt and ETV alone in North America are greatly lacking. To address this, the Hydrocephalus Clinical Research Network (HCRN) conducted a prospective study of ETV+CPC in infants. Here, these prospective data are presented and compared to prospectively collected data from a historical cohort of infants treated with shunt or ETV alone.METHODSFrom June 2014 to September 2015, infants (corrected age ≤ 24 months) requiring treatment for hydrocephalus with anatomy suitable for ETV+CPC were entered into a prospective study at 9 HCRN centers. The rate of procedural failure (i.e., the need for repeat hydrocephalus surgery, hydrocephalus-related death, or major postoperative neurological deficit) was determined. These data were compared with a cohort of similar infants who were treated with either a shunt (n = 969) or ETV alone (n = 74) by creating matched pairs on the basis of age and etiology. These data were obtained from the existing prospective HCRN Core Data Project. All patients were observed for at least 6 months.RESULTSA total of 118 infants underwent ETV+CPC (median corrected age 1.3 months; common etiologies including myelomeningocele [30.5%], intraventricular hemorrhage of prematurity [22.9%], and aqueductal stenosis [21.2%]). The 6-month success rate was 36%. The most common complications included seizures (5.1%) and CSF leak (3.4%). Important predictors of treatment success in the survival regression model included older age (p = 0.002), smaller preoperative ventricle size (p = 0.009), and greater degree of CPC (p = 0.02). The matching algorithm resulted in 112 matched pairs for ETV+CPC versus shunt alone and 34 matched pairs for ETV+CPC versus ETV alone. ETV+CPC was found to have significantly higher failure rate than shunt placement (p < 0.001). Although ETV+CPC had a similar failure rate compared with ETV alone (p = 0.73), the matched pairs included mostly infants with aqueductal stenosis and miscellaneous other etiologies but very few patients with intraventricular hemorrhage of prematurity.CONCLUSIONSWithin a large and broad cohort of North American infants, our data show that overall ETV+CPC appears to have a higher failure rate than shunt alone. Although the ETV+CPC results were similar to ETV alone, this comparison was limited by the small sample size and skewed etiological distribution. Within the ETV+CPC group, greater extent of CPC was associated with treatment success, thereby suggesting that there are subgroups who might benefit from the addition of CPC. Further work will focus on identifying these subgroups.