bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrolide use in the previous years is associated with failure to eradicate Helicobacter pylori with clarithromycin‐containing regimens
Authors: Muñoz‐Gómez Pablo , Jordán‐Castro Junior Alexander , Abanades‐Tercero María , Blanco‐González José Javier , Andrés Esteban Eva María , Valle‐Muñoz Julio 
Published: November 2017

AbstractBackgroundThere is some evidence that prior use of macrolide antibiotics is a useful predictor of the likelihood of standard triple therapy failure in Helicobacter pylori eradication. In this study, we have evaluated whether previous intake of macrolides correlates with failure to eradicate H. pylori using two different first‐line clarithromycin‐containing regimens.Materials and MethodsRetrospective study of 212 patients with H. pylori infection treated with one of two first‐line clarithromycin‐containing regimens: 108 patients treated with triple therapy for 10 days and 104 patients treated with concomitant therapy for 10 days. The intake of macrolides (clarithromycin, azithromycin, and other macrolides) prior to the eradication therapy was obtained from the electronic medical record, which contains information regarding all the medication prescribed to the patients since the year 2004.ResultsOne hundred of 212 patients (47.2%) had received at least one treatment with macrolides during the years prior to the eradication therapy. H. pylori eradication rates were significantly lower in patients with previous use compared to patients without previous use of macrolides, both with triple therapy (60.8% vs 92.9%; P < .0001) and with concomitant therapy (85.7% vs 98.2%; P = .024).ConclusionsPrevious use of macrolides correlates with a low H. pylori eradication rate with triple and concomitant clarithromycin‐containing regimens. In addition, our study shows that in patients without previous use of macrolides, triple therapy achieves per‐protocol eradication rates over 90%.
A meta‐analysis of the association between Helicobacter pylori (H. pylori) infection and hyperemesis gravidarum
Authors: Ng Qin Xiang , Venkatanarayanan Nandini , De Deyn Michelle Lee Zhi Qing , Ho Collin Yih Xian , Mo Yin , Yeo Wee‐Song 
Published: November 2017

AbstractBackgroundHyperemesis gravidarum remains a common, distressing, and significant yet poorly understood disorder during pregnancy. The association between maternal Helicobacter pylori (H. pylori) infection and hyperemesis gravidarum has been increasingly recognized and investigated. This study thus aimed to provide an updated review and meta‐analysis of the topic.MethodsUsing the search terms (H. pyloriOR Helicobacter ORHelicobacter pyloriOR infection) AND (pregnancy OR emesis OR hyperemesis gravidarum OR nausea OR vomiting), a preliminary search on the PubMed, Ovid, Web of Science, Google Scholar, and WanFang database yielded 372 papers published in English between January 1st, 1960 and June 1st, 2017.ResultsA total of 38 cross‐sectional and case‐control studies, with a total of 10 289 patients were eligible for review. Meta‐analysis revealed a significant association between H. pylori infection and hyperemesis gravidarum during pregnancy, with a pooled odds ratio of 1.348 (95% CI: 1.156‐1.539, P < .001). Subgroup analysis found that serologic and stool antigen tests were comparable methods of detecting H. pylori as they yielded similar odds ratios.LimitationsAlthough the studies did not have high heterogeneity (I2 = 28%), publication bias was observed, and interstudy discrepancies in the diagnostic criteria adopted for hyperemesis gravidarum limit the reliability of findings. Also, 15 of the included studies were from the same country (Turkey), which could limit the generalizability of current findings. The prevalence of H. pylori infection varies throughout the world, and there may also be pathogenic differences as most strains of H. pylori in East Asia carry the cytotoxin‐associated gene A gene.ConclusionH. pylori infection was associated with an increased likelihood of hyperemesis gravidarum during pregnancy. Given the high prevalence of H. pylori infections worldwide, detecting H. pylori infection and the eradication of maternal H. pylori infection could be part of maternal hyperemesis gravidarum management. Further confirmation with robust longitudinal studies and mechanistic investigations are needed.
Whose curriculum is it anyway? Stakeholder salience in the context of Degree Apprenticeships
Authors: Powell Philip , Walsh Anita 
Published: November 2017

AbstractA Degree Apprenticeship model has recently been introduced into the United Kingdom (UK) Higher Education system as part of wider changes to vocational training. The system has experienced numerous rapid changes in regulation and funding, and it is now little understood by many stakeholders. Distinguishing different phases in UK Higher Education, and using a salience model as a lens for analysis, this article identifies and examines stakeholders with regards to their influence on the Higher Education curriculum. The new Degree Apprenticeship model is funded by an employer payroll levy and it requires Higher Education institutions to deliver training to specific standards. This research explores the implications of the model for the Higher Education curriculum, concluding that the direct involvement of employers in the design and delivery of vocational Higher Education introduces untried elements into UK Higher Education on the assumption that the funding requirement will lead to a change in employer behaviour. This, coupled with the opening of Higher Education provision to private providers, transfers power over the curriculum to those with potentially no commitment to wider public values, and may offer a threat to the international standing of UK Higher Education. This article contributes to research in understanding how Higher Education systems respond to, and actors cope with, imposed change.
Evaluation of apical transportation and centring ability of five thermally treated NiTi rotary systems
Authors: Pinheiro S. R. , Alcalde M. P. , Vivacqua‐Gomes N. , Bramante C. M. , Vivan R. R. , Duarte M. A. H. , Vasconcelos B. C. 
Published: November 2017

AbstractAimTo evaluate apical transportation and centring ability during root canal preparation in mesial root canals of mandibular molars associated with ProTaper Gold (PTG), ProDesign S (PDS), Hyflex CM (HCM), Hyflex EDM and ProDesign Logic (PDL).MethodologySixty mandibular first molars with two separate canals in the mesial root were selected after root anatomy pairing by microcomputed tomography (microCT). The teeth were randomly divided into five groups (n = 24); the root canal volume was calculated to ensure sample homogeneity. All the root canals were prepared up to size 25 in accordance with the instructions of each rotary system manufacturer. After root canal preparation, the teeth were scanned by microCT to analyse apical transportation, root canal centralization and the pre‐ and post‐preparation root canal volume at the apical and cervical levels. Kruskal–Wallis and Dunn tests were used for comparisons amongst groups for transportation values. For volume changes, the parametric ANOVA and Tukey’s tests were usedResultsThere were no significant differences in apical transportation amongst the rotary systems (P > 0.05). All the systems created apical transportation; values ranging from 0.031 mm (PDL) to 0.072 mm (PTG), and enlargements between 39% (HCM) and 91.1% (PDS) were observed. In relative to cervical transportation, significant differences were observed amongst the systems (P < 0.05). Mean transportation values between 0.07 mm (HCM) and 0.172 mm (PTG) were found, with enlargements between 35.4% (HCM) and 51.5% (PDS).ConclusionAll the thermally treated systems resulted in similar apical transportation. In the cervical region, the Hyflex CM and Prodesign Logic systems were associated with more centred preparations.
SINGLE MOMS AND DEADBEAT DADS: THE ROLE OF EARNINGS, MARRIAGE MARKET CONDITIONS, AND PREFERENCE HETEROGENEITY
Authors: Beauchamp Andrew , Sanzenbacher Geoffrey , Seitz Shannon , Skira Meghan M. 
Published: November 2017

AbstractWhy do some men father children outside of marriage without providing support? Why do some women have children outside of marriage when they receive little support from fathers? Why is this behavior more common among Blacks than Whites? We estimate a dynamic equilibrium model of marriage, employment, fertility, and child support decisions. We consider the extent to which low earnings, marriage market conditions, and preference heterogeneity explain nonmarital childbearing, deadbeat fatherhood, and racial differences in these outcomes. We find the Black–White earnings gap and preference heterogeneity explain a substantial portion of racial differences, whereas marriage market conditions are less important.
Influence of radiative heat transfer model on the computation of residual stresses in glass tempering process
Authors: Agboka Kossiga , Béchet Fabien , Siedow Norbert , Lochegnies Dominique 
Published: November 2017

AbstractDuring glass tempering, residual stresses are caused by the temperature gradient appearing between the surface and the core of the glass. It is therefore necessary to have an accurate knowledge of the heat transfer occurring during the process to obtain an accurate estimation of the residual stresses. Since glass is a semitransparent material, radiative heat transfer takes place inside the glass in addition to the conductive heat transfer. In this paper, we implemented 1‐D thermomechanical models using different methods for the computation of the radiative effects inside the glass: Rosseland approximation, P1 approximation and back ray tracing. Thermal and residual stresses results are compared to experimental results available in the literature to investigate the effects of the different methods on the heat transfer and mechanical behavior. We found that P1 approximation and back ray tracing are in good agreement with the experimental results. Finally, a numerical investigation is done by changing different parameters for which the experimental results are not available.
Is the open cystectomy era over? An update on the available evidence
Authors: Tyritzis Stavros I , Wiklund N Peter 
Published: November 2017

AbstractIn 2018, robot‐assisted radical cystectomy will enter its 15th year. In an era where an effort is being made to standardize complication reporting and videos of the procedure are readily available, it is inevitable and justified that like everything novel, robot‐assisted radical cystectomy should be scrutinized against the gold standard, open radical cystectomy. The present comparison is focused on several parameters: oncological, functional and complication outcomes, and direct and indirect costs. Meta‐analysis and prospective randomized trials comparing robot‐assisted radical cystectomy versus open radical cystectomy have been published, showing an oncological equivalence and in some cases an advantage of robot‐assisted radical cystectomy in terms of postoperative morbidity. In the present review, we attempt to update the available knowledge on this debate and discuss the limitations of the current evidence that prevent us from drawing safe conclusions.
A comparison of accuracy validation methods for genomic and pedigree‐based predictions of swine litter size traits using Large White and simulated data
Authors: Putz A.M. , Tiezzi F. , Maltecca C. , Gray K.A. , Knauer M.T. 
Published: November 2017

SummaryThe objective of this study was to compare and determine the optimal validation method when comparing accuracy from single‐step GBLUP (ssGBLUP) to traditional pedigree‐based BLUP. Field data included six litter size traits. Simulated data included ten replicates designed to mimic the field data in order to determine the method that was closest to the true accuracy. Data were split into training and validation sets. The methods used were as follows: (i) theoretical accuracy derived from the prediction error variance (PEV) of the direct inverse (iLHS), (ii) approximated accuracies from the accf90(GS) program in the BLUPF90 family of programs (Approx), (iii) correlation between predictions and the single‐step GEBVs from the full data set (GEBVFull), (iv) correlation between predictions and the corrected phenotypes of females from the full data set (Yc), (v) correlation from method iv divided by the square root of the heritability (Ych) and (vi) correlation between sire predictions and the average of their daughters' corrected phenotypes (Ycs). Accuracies from iLHS increased from 0.27 to 0.37 (37%) in the Large White. Approximation accuracies were very consistent and close in absolute value (0.41 to 0.43). Both iLHS and Approx were much less variable than the corrected phenotype methods (ranging from 0.04 to 0.27). On average, simulated data showed an increase in accuracy from 0.34 to 0.44 (29%) using ssGBLUP. Both iLHS and Ych approximated the increase well, 0.30 to 0.46 and 0.36 to 0.45, respectively. GEBVFull performed poorly in both data sets and is not recommended. Results suggest that for within‐breed selection, theoretical accuracy using PEV was consistent and accurate. When direct inversion is infeasible to get the PEV, correlating predictions to the corrected phenotypes divided by the square root of heritability is adequate given a large enough validation data set.
Women's attractiveness is linked to expected age at menopause
Authors: Bovet J. , Barkat‐Defradas M. , Durand V. , Faurie C. , Raymond M. 
Published: November 2017

AbstractA great number of studies have shown that features linked to immediate fertility explain a large part of the variance in female attractiveness. This is consistent with an evolutionary perspective, as men are expected to prefer females at the age at which fertility peaks (at least for short‐term relationships) in order to increase their reproductive success. However, for long‐term relationships, a high residual reproductive value (the expected future reproductive output, linked to age at menopause) becomes relevant as well. In that case, young age and late menopause are expected to be preferred by men. However, the extent to which facial features provide cues to the likely age at menopause has never been investigated so far. Here, we show that expected age at menopause is linked to facial attractiveness of young women. As age at menopause is heritable, we used the mother's age at menopause as a proxy for her daughter's expected age of menopause. We found that men judged faces of women with a later expected age at menopause as more attractive than those of women with an earlier expected age at menopause. This result holds when age, cues of immediate fertility and facial ageing were controlled for. Additionally, we found that the expected age at menopause was not correlated with any of the other variables considered (including immediate fertility cues and facial ageing). Our results show the existence of a new correlate of women's facial attractiveness, expected age at menopause, which is independent of immediate fertility cues and facial ageing.
Association between Helicobacter pylori infection and gallbladder diseases: A retrospective study
Authors: Xu Mei‐Yan , Ma Jia‐Hui , Yuan Bao‐Shi , Yin Jian , Liu Lan , Lu Qing‐Bin 
Published: November 2017

AbstractBackground and AimThe association between Helicobacter pylori (H. pylori) and gallbladder diseases is still unclear and is controversial. We conducted a retrospective study to clarify the prevalence of gallbladder diseases and factors related to gallbladder diseases and relationships between H. pylori infection, gallstones, cholecystitis, and cholecystic polypus.MethodsThe retrospective study was performed at the Aerospace Center Hospital in Beijing. The subjects in this study were a healthy population who underwent health examinations at the hospital between 2012 and 2015. The logistic regression models were used to explore the relationships between H. pylori infection and gallbladder diseases.ResultsThere were 7803 (43.4%) subjects with H. pylori infection, 995 (5.5%) with gallstones, 219 (1.2%) with cholecystitis, and 1003 (5.6%) with cholecystic polypus amongst 17 971 subjects, respectively. In subjects aged 45 years or less, the prevalence of gallstones in the H. pylori (+) group was lower than that in the H. pylori (−) group (odds ratio = 0.653; 95% confidence interval: 0.468–0.911; P = 0.012). The prevalence of cholecystic polypus in the H. pylori (+) group was significantly higher than that in the H. pylori (−) group (odds ratio = 1.160; 95% confidence interval: 1.012–1.328; P = 0.033).ConclusionsHelicobacter pylori infection was related with cholecystic polypus and gallstones in a Chinese population.
Community Program Improves Quality of Life and Self‐Management in Older Adults with Diabetes Mellitus and Comorbidity
Authors: Markle‐Reid Maureen , Ploeg Jenny , Fraser Kimberly D. , Fisher Kathryn A. , Bartholomew Amy , Griffith Lauren E. , Miklavcic John , Gafni Amiram , Thabane Lehana , Upshur Ross 
Published: November 2017

ObjectivesTo compare the effect of a 6‐month community‐based intervention with that of usual care on quality of life, depressive symptoms, anxiety, self‐efficacy, self‐management, and healthcare costs in older adults with type 2 diabetes mellitus (T2DM) and 2 or more comorbidities.DesignMultisite, single‐blind, parallel, pragmatic, randomized controlled trial.SettingFour communities in Ontario, Canada.ParticipantsCommunity‐dwelling older adults (≥65) with T2DM and 2 or more comorbidities randomized into intervention (n = 80) and control (n = 79) groups (N = 159).InterventionClient‐driven, customized self‐management program with up to 3 in‐home visits from a registered nurse or registered dietitian, a monthly group wellness program, monthly provider team case conferences, and care coordination and system navigation.MeasurementsQuality‐of‐life measures included the Physical Component Summary (PCS, primary outcome) and Mental Component Summary (MCS, secondary outcome) scores of the Medical Outcomes Study 12‐item Short‐Form Health Survey (SF‐12). Other secondary outcome measures were the Generalized Anxiety Disorder Scale, Center for Epidemiologic Studies Depression Scale (CES‐D‐10), Summary of Diabetes Self‐Care Activities (SDSCA), Self‐Efficacy for Managing Chronic Disease, and healthcare costs.ResultsMorbidity burden was high (average of eight comorbidities). Intention‐to‐treat analyses using analysis of covariance showed a group difference favoring the intervention for the MCS (mean difference = 2.68, 95% confidence interval (CI) = 0.28–5.09, P = .03), SDSCA (mean difference = 3.79, 95% CI = 1.02–6.56, P = .01), and CES‐D‐10 (mean difference = −1.45, 95% CI = −0.13 to −2.76, P = .03). No group differences were seen in PCS score, anxiety, self‐efficacy, or total healthcare costs.ConclusionParticipation in a 6‐month community‐based intervention improved quality of life and self‐management and reduced depressive symptoms in older adults with T2DM and comorbidity without increasing total healthcare costs.
Investigating the response of biotite to impact metamorphism: Examples from the Steen River impact structure, Canada
Authors: Walton E. L. , Sharp T. G. , Hu J. , Tschauner O. 
Published: November 2017

AbstractImpact metamorphic effects from quartz and feldspar and to a lesser extent olivine and pyroxene have been studied in detail. Comparatively, studies documenting shock effects in other minerals, such as double chain inosilicates, phyllosilicates, carbonates, and sulfates, are lacking. In this study, we investigate impact metamorphism recorded in crystalline basement rocks from the Steen River impact structure (SRIS), a 25 km diameter complex crater in NW Alberta, Canada. An array of advanced analytical techniques was used to characterize the breakdown of biotite in two distinct settings: along the margins of localized regions of shock melting and within granitic target rocks entrained as clasts in a breccia. In response to elevated temperature gradients along shock vein margins, biotite transformed at high pressure to an almandine‐Ca/Fe majorite‐rich garnet with a density of 4.2 g cm−3. The shock‐produced garnets are poikilitic, with oxide and silicate glass inclusions. Areas interstitial to garnets are vesiculated, in support of models for the formation of shock veins via oscillatory slip, with deformation continuing during pressure release. Biotite within granitic clasts entrained within the hot breccia matrix thermally decomposed at ambient pressure to produce a fine‐grained mineral assemblage of orthopyroxene + sanidine + titanomagnetite. These minerals are aligned to the (001) cleavage plane of the original crystal. In this and previous work, the transformation of an inosilicate (pargasite) and a phyllosilicate (biotite) to form garnet, an easily identifiable, robust mineral, has been documented. We contend that in deeply eroded astroblemes, high‐pressure minerals that form within or in the environs of shock veins may serve as one of the possibly few surviving indicators of impact metamorphism.
Peptidoglycan in obligate intracellular bacteria
Authors: Otten Christian , Brilli Matteo , Vollmer Waldemar , Viollier Patrick H. , Salje Jeanne 
Published: November 2017

SummaryPeptidoglycan is the predominant stress‐bearing structure in the cell envelope of most bacteria, and also a potent stimulator of the eukaryotic immune system. Obligate intracellular bacteria replicate exclusively within the interior of living cells, an osmotically protected niche. Under these conditions peptidoglycan is not necessarily needed to maintain the integrity of the bacterial cell. Moreover, the presence of peptidoglycan puts bacteria at risk of detection and destruction by host peptidoglycan recognition factors and downstream effectors. This has resulted in a selective pressure and opportunity to reduce the levels of peptidoglycan. In this review we have analysed the occurrence of genes involved in peptidoglycan metabolism across the major obligate intracellular bacterial species. From this comparative analysis, we have identified a group of predicted ‘peptidoglycan‐intermediate’ organisms that includes the Chlamydiae, Orientia tsutsugamushi, Wolbachia and Anaplasma marginale. This grouping is likely to reflect biological differences in their infection cycle compared with peptidoglycan‐negative obligate intracellular bacteria such as Ehrlichia and Anaplasma phagocytophilum, as well as obligate intracellular bacteria with classical peptidoglycan such as Coxiella, Buchnera and members of the Rickettsia genus. The signature gene set of the peptidoglycan‐intermediate group reveals insights into minimal enzymatic requirements for building a peptidoglycan‐like sacculus and/or division septum.