bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasticidade morfológica de Calophyllum brasiliense Camb. (Calophyllaceae) em duas formações de restinga no sul do Brasil
Authors: Bachtold Barbra Aliane , Ferreira de Melo Junior João Carlos 
Published: April 2017

Fatores ambientais podem promover alterações nas características funcionais e estruturais dosorganismos a eles expostos. Essa capacidade de variação na fisiologia ou morfologia é conhecidacomo plasticidade. Em ambientes heterogêneos como a restinga as espécies apresentam grande potencial plástico. O presente trabalho visa avaliar a plasticidade morfológica de Calophyllum brasiliense Cambess. (Calophyllaceae), popularmente conhecido como olandi,em duas formações de restinga do Parque Estadual Acaraí, localizado no município de São Francisco do Sul/SC (48º33’ W e 26º17’ S). Em cada formação, cinco indivíduos adultos foram selecionados para coleta de folhas de sol e amostras de caule, além da coleta de solo para obtenção de valores nutricionais e de fertilidade. Atributos foliares e de xilema, qualitativos e quantitativos, foram obtidos por meio de material herborizado e preparações histológicas permanentes, respectivamente. Observaram-se diferenças estatísticas significativas para os parâmetros de área foliar, massa seca e índice de condutividade entre as populações.Com base nos dados obtidos, sugere-se que os indivíduos presentes na restinga arbustivoarbórea estão mais sombreados e têm mais biomassa foliar acumulada, enquanto na floresta de transição C. brasiliense apresenta maior investimento em altura e diâmetro do caule. Verificou-se maior plasticidade fenotípica para os parâmetros de massa seca foliar e área foliar. Os parâmetros nutricionais demonstraram alto teor de matéria orgânica na floresta detransição, propiciando alto nível de fertilidade.
Orchidaceae Flora of Joinville, Santa Catarina, Brazil
Authors: Mancinelli Werner Siebje , Esemann-Quadros Karin 
Published: April 2017

The objective of this work was to conduct a floristic study of Orchidaceae in the municipality of Joinville (Santa Catarina, Brazil), which occurred from 2006 to 2015. The municipality is mainly covered with Atlantic Forest between 0 and 1,335 m elevation. For the family, 211 species within 90 genera were recorded. The richest genera are Epidendrum (17 spp.), Pabstiella (15 spp.), Acianthera (14 spp.), Anathallis (8 spp.) and Octomeria (8 spp.). The majority of the species are epiphytes (82%), 11% are terrestrial, and the remaining 7% are hemi-epiphytes, rupicolous or myco-heterotrophic. Two species, Grobya guiselii and Homalopetalum joinvillense, are known only from Joinville.Keywords: Atlantic Forest; Floristic; Orchids; South Brazilian.
Nesting patterns of bees (Apidae) in brick walls in southern Brazil
Authors: K. G. dos Santos Andressa , Warkentin Manuel , V. da Silva Juliane , N. Barbosa Rogério , Mouga Denise Monique Dubet da Silva 
Published: April 2017

Aiming to verify the nesting pattern of solitary bee species, a study was performed (October 2012 to March 2013) in Joinville, SC, southern Brazil, along a brick wall. There were found the following species Melitoma segmentaria (Emphorini), Caenohalictus incertus (Halictini)and Leiopodus lacertinus (Protepeolini). 147 nests showed activity in the sampling period (118 of C. incertus, 29 of M. segmentaria), 98% located in the masonry. For M. segmentaria, 29 active nests were observed (density of 4.53/ m2), with an average distance of 12.22 cmbetween them, 17 nests between the ground and 90 cm high, istributed in aggregated form (R = 0.004, p <0.02). The nests opening measured on average 0.9 cm in diameter (n =29), two of them with a mud tower entrance 0.6 cm high, with a smooth inner wall and a outer, rough. For C. incertus, 118 active nests were observed (density of 18.43/ m2), with a mean distance of 8.18 cm from each other, 98 nests between the ground and 70 cm high, distributed in aggregated form (R = 0.066, p <0.09). Individuals of L. lacertinus were noticed in all observations days, at the entrance of nests of M. segmentaria. Anthrax cf. virgo emerged from M. segmentaria nests.
Morphological plasticity of Ilex theezans Mart. ex Reissek (Aquifoliaceae) in two restinga vegetation of Santa Catarina coastal plain
Authors: Liberato Izabel da Silva , Melo Junior João Carlos Ferreira 
Published: April 2017

The restinga, an environment of the rain Forest, is an ecosystem by the seacoast composed of diverse plant communities commonly found in sandy and undeveloped soils. This study aims to investigate possible intraspecific differences in Ilex theezans species, whose distributionin restinga includes two heterogeneous formations, shrub-tree restinga and transition forest. The study focused on a restinga remnant area located in Acaraí State Park, in the city of São Francisco do Sul (SC, Brazil). In each environment, five adult individuals were selected andhad wood samples collected from their stems at breast height and 25 leaves of the third and fourth nodes of the outer canopy branches sampled. Chemical and physical soil variables were analyzed for each formation. The results show that there are significant differencesbetween the leaf and the stem functional attributes and soil data analyzed, but as the PPI (Phenotypic Plasticity Index), the species Ilex theezans in the studied formations present low plastic potential.
Diatomáceas fitoplanctônicas da Praia do Gi, Laguna, Santa Catarina, Brasil
Authors: Dutra Débora Bärwaldt , Garcia Marinês 
Published: April 2017

Amostras do fitoplâncton marinho costeiro foram coletadas na Praia do Gi (Laguna, Brasil) com rede de plâncton de malha 20 μm em março de 2014. Foram encontradas 74 espécies de diatomáceas, pertencentes a 49 gêneros. As espécies estudadas são listadas com suas respectivas dimensões celulares juntamente com imagens em microscopia óptica emicroscopia eletrônica de varredura. Thalassiosira foi o gênero com o maior número de espécies, sendo Thalassiosira profunda pela primeira vez registrada para o Oceano Atlântico Sul. Anaulus australis apresenta sua distribuição austral ampliada para 28° S.
Levantamento da fauna de abelhas sem ferrão no estado do Tocantins
Authors: Costa-Neto Diôgo Januário , Valadares Marcela Sousa , Silva-Costa Edmilson Soares , Souto José Neuto 
Published: April 2017

As espécies de abelhas sem ferrão existentes no estado do Tocantins são pouco conhecidas e precisam ser investigadas, pois as informações existentes estão restritas aos meliponicultores locais. Este estudo teve como objetivo levantar dados sobre a riqueza e a distribuição das espécies de abelhas sem ferrão existentes no Tocantins. Realizou-se um levantamento bibliográfico e foram entrevistados 33 meliponicultores de 18 municípios do estado. A literatura revela a ocorrência de 31 espécies, semelhantes às 34 verificadas nos sistemas de meliponicultura. As mais frequentes são: jataí (94,4%), tiúba (88,9%) tubi bravo (77,7%), uruçu amarela (66,7%), uruçu preta (55,5%), manoel de abreu (33,3%) e marmelada (33,3%). As abelhas com maior número de colmeias são tiúba (335), jataí (143), uruçu amarela (125), tubi bravo (61), manoel de abreu (49) e bijuí (39).
Potential Economic and Development Prospects of Non Timber Forest Products in Community Agroforestry Land Around Sibolangit Tourism Park
Authors: Affandi Oding , Zaitunah Anita , Batubara Ridwanti 
Published: April 2017

The communities who live around Sibolangit Tourism Park have developed nontimber forest products (NTFP) in their own agroforestry lands. This research evaluates the potential economic and development prospects from NTFP development in the Park by examining: (1) type of NTFP and economic value from community agrofrestry land, (2) contribution of NTFPs on household income, (3) development prospects of NTFP-based agroforestry around Sibolangit Tourism Park. The research was conducted in two selected villages around Sibolangit Tourism Park: Sembahe Village and Batu Mbelin Village. The research took place over a period between June and August 2016. Research data was obtained from in-depth interviews and observations. A descriptive method was used to analyze and describe facts related to the research aims. The type of NTFPs cultivated by communities at the research sites include mangosteen, durian, garcinia, candlenut, lanzones, lansium, bitter bean, and areca nut (as their forestry component) and ginger, turmeric, chili, papaya, etlingera, and banana (as the agriculture component). Most NTFPs are cultivated as a comercial product. The economic value of NTFPs in Batu Mbelin Village has reached Rp. 547,275,000/year or contribute 80.07% of total family income. Meanwhile, the economic value of NTFPs in Sembahe Village has reached Rp 682,100,000/year, contributing to 78.75% of total household income. Therefore, the prospects for supporting and expanding NTFP in agroforestry plots in and around Sibolangit Tourism Park has high potential for supporting household income
Evolution of Sinonasal Symptoms and Mucosal Healing after Minimally Invasive Pituitary Surgery
Authors: Chaudhry Shiven , Chaudhry Sharang , Qureshi Talha , Batra Pete S. 
Published: April 2017

Background Minimally invasive pituitary surgery (MIPS) via endoscopy has become widely accepted as the surgical paradigm of choice for pituitary pathology. The objective of the current study was to analyze the evolution of symptom scores and mucosal healing after MIPS. Methods The 22-item Sino-Nasal Outcome Test (SNOT-22) scores and objective endoscopic data of 52 patients were reviewed in a longitudinal manner. Scaled averages of the SNOT-22 and endoscopic scores from different time points were compared with baseline scores by using nonparametric testing. The time to baseline for endoscopic examinations was also analyzed by using Kaplan-Meier curves. Results The rhinologic symptoms subdomain of the SNOT-22 scores showed statistically significant worsening between baseline and 2 weeks after surgery (p = 0.03). Follow-up SNOT-22 scores after 2 weeks showed no significant differences compared with baseline scores, with an overall trend toward improvement in patient symptoms during the subsequent period. Similar analysis for the endoscopic data illustrated statistically significant differences from the baseline scores up to 16 weeks after surgery. The overall trend showed a worsened endoscopic examination, initially with a spike at ∼8 to 10 weeks (p = 0.03) and with a subsequent return to baseline. The Kaplan-Meier estimate curve demonstrated a median time to return to baseline endoscopy at 18.9 weeks (95% confidence interval, 14.9-38.3 weeks). Conclusion The longitudinal data exhibited subjective improvement of patient outcomes based on SNOT-22 scores within 2-4 weeks after MIPS. However, the objective endoscopic data revealed a lag in improvement of the examination, typically at 16-20 weeks, which underscores ongoing careful endoscopic assessment and management to ensure proper mucosal healing beyond just subjective symptoms as the gauge to postoperative recovery.
Complete Surgical Resection and Short-Term Survival in Acute Invasive Fungal Rhinosinusitis
Authors: Roxbury Christopher R. , Smith David F. , Higgins Thomas S. , Lee Stella E. , Gallia Gary L. , Ishii Masaru , Lane Andrew P. , Reh Douglas D. 
Published: April 2017

Background Acute invasive fungal rhinosinusitis (AIFR) is a fulminant fungal infection seen in patients who are immunocompromised. Due to its rarity, there is little evidence regarding the appropriate antifungal treatment regimen, especially the degree of surgical intervention. Objective To assess factors that impact short-term survival in AIFR as defined by survival to hospital discharge and to develop a staging system to predict survival and complete surgical resection. Methods Fifty-four patients with histopathologically diagnosed AIFR who met inclusion criteria were identified between 1984 and 2014. Patient characteristics, disease extent, treatment modality, and short-term survival data were collected. Univariate analysis was performed to assess for factors associated with survival and increased likelihood of surgical resection. Results Of 52 patients with adequate documentation, 36 (69.2%) survived their hospital stay. Complete surgical resection was the only factor associated with improved survival (survival, 95.5%; p < 0.01). A surgical staging system was proposed to guide probability of complete resection and overall prognosis, with stage I disease limited to the nasal cavity, stage II involving the paranasal sinuses, stage III involving the orbit, and stage IV with skull base or intracranial extension. The χ2 analyses showed a decreased likelihood of complete surgical resection with stage III or IV disease compared with stage I (resection, 90.9%) (stage III resection, 37.5% [p = 0.01]; stage IV resection, 16.7% [p = 0.002]). There was a decreased likelihood of survival associated with increasing disease stage compared with stage I (survival, 100%) (stage II survival, 60% [p = 0.009]; stage III survival, 62.5% [p = 0.02]; stage IV survival, 54.6%, [p = 0.006]). Conclusion Although further studies are needed to define specific treatment protocols, analysis of these data indicated that endoscopic sinus surgery with the goal of complete surgical resection may provide the best survival outcomes in select patients when complete surgical resection can be performed. Our staging system represents the first attempt to predict surgical success and prognosis in patients with AIFR.
Respiratory Viral Detection in the Paranasal Sinuses of Patients with Cystic Fibrosis
Authors: Rowan Nicholas R. , Wang Eric W. , Kanaan Alyssa , Sahu Nivedita , Williams John V. , Phillips Caleb D. , Lee Stella E. 
Published: April 2017

Background Pulmonary colonization with antibiotic-resistant organisms in patients with cystic fibrosis (CF) is often preceded by upper-airway infections. Although there is a well-described relationship between pulmonary respiratory viral infections and overall disease progression of CF, the pathogenicity of respiratory viral infections in the paranasal sinuses of patients with CF remains unknown. With recent advances in respiratory virus detection techniques, this study sought to detect the presence of respiratory viruses in the paranasal sinuses of patients with CF in comparison with healthy controls and to correlate the viral presence with clinical measures of sinonasal disease. Methods This prospective individual cohort study compared 24 patients with CF with 14 healthy controls. Basic demographics, clinical measures of disease and respiratory viral screens (commercial multiplex) obtained directly from the paranasal sinuses were compared between the two groups. Results Respiratory viruses were detected in 33% of patients with CF (8/24) compared with 0% of the healthy controls (0/14) (p = 0.017). Respiratory viruses were only detected during the winter months, and the most commonly identified were influenza A and human rhinovirus strains. There was no statistical difference in the 22-Item Sino-Nasal Outcome Test (SNOT-22) scores (p = 0.93) or modified Lund-Kennedy scores (p = 0.74) between patients with CF with a positive viral test and those without a positive result. Conclusions Respiratory viral detection is more commonly detected in the paranasal sinuses of patients with CF compared with healthy controls. Although respiratory viral presence did not correlate with a worse clinical severity of sinonasal disease, these findings may provide insight into the pathophysiology of CF and open new avenues for potential targeted therapy.
Fully endoscopic combined transsphenoidal and supraorbital keyhole approach for parasellar lesions
Authors: Nagata Yuichi , Watanabe Tadashi , Nagatani Tetsuya , Takeuchi Kazuhito , Chu Jonsu , Wakabayashi Toshihiko 
Published: April 2017

OBJECTIVEParasellar tumors that extend far laterally beyond the internal carotid artery or that are fibrous and adhere firmly to critical structures are difficult to remove totally via the endoscopic transsphenoidal approach alone. In such cases, a combined transsphenoidal-transcranial approach is effective to achieve maximal resection in a single stage. In this paper, a new minimally invasive surgical technique for complicated parasellar lesions, a fully endoscopic combined transsphenoidal–supraorbital keyhole approach, is presented.METHODSA retrospective review of patients who had been treated via a fully endoscopic combined transsphenoidal–supraorbital keyhole approach for complicated parasellar lesions was performed. The data for resection rate, perioperative mortality and morbidity, and postoperative outcomes were analyzed.RESULTSA total of 12 fully endoscopic combined transsphenoidal–supraorbital keyhole approaches were performed from March 2013 to February 2016; 10 were for pituitary adenomas and 2 were for craniopharyngiomas. Gross-total resection or near-total resection was achieved in 7 of 12 cases. Among the 11 patients who had presented with preoperative visual disturbances, 7 had visual improvement. However, 1 patient showed deterioration in visual function. No patient experienced postoperative hemorrhage, needed additional surgical treatment, or had postoperative CSF leakage.CONCLUSIONSIn the combined transsphenoidal and transcranial approach, safe and effective cooperative manipulation with 2 surgical corridors can be performed for complicated parasellar lesions. The goal of this procedure is not to achieve gross-total resection, but to achieve safe resection. Moreover, this new surgical approach offers neurosurgeons a simpler operative field with less invasiveness than the conventional microscopic combined approach. The fully endoscopic combined endonasal–supraorbital keyhole approach is an efficacious procedure for complicated parasellar lesions with acceptable results.
CDK4/6 Inhibitors in Cancer Therapy: A Novel Treatement Strategy for Bladder Cancer
Authors: Pan Qi , Sathe Anuja , Black Peter C. , Goebell Peter J. , Kamat Ashish M. , Schmitz-Draeger Bernd , Nawroth Roman 
Published: April 2017

Patients with metastatic bladder cancer (mBC) treated with cisplatin-based chemotherapy have a limited median survival of only around 14 months [ 1 ]. Despite over 30 years of basic and clinical research, until recently no therapeutic options beyond cisplatin-based therapy had entered clinical routine and, at least in the US, none of the tested agents had been approved for second-line treatment. This has changed with the advent of immune checkpoint blockade, including especially PD-1/PD-L1 inhibitors. The high response rates of 24% over a 14.4 month follow up led to the first US Food and Drug Administration (FDA) approval for a second line therapy for these patients, and it is likely that this marks the beginning of a new era in the systemic treatment of muscle-invasive bladder cancer [ 2 – 4 ]. The strong clinical need to improve the medical management of this disease for those patients, not responding to current therapy has led to an increased molecular understanding of bladder cancer and has forstered the development of many potential molecular manipulations and targeted strategies beyond the new immune-oncologic approaches. Among the molecular alterations indentified in bladder cancer, cell cycle deregulation appears to be a key driver of disease progression. Target-directed therapy against CDK4/6 is an emerging strategy to regain control of cell cycle deregulation. Here, we provide an overview of the current status of CDK4/6 inhibitors in cancer therapy, their potential use in mBC and the challenges for their clinical use.
Prodromal Dementia with Lewy Bodies and Prodromal Alzheimer’s Disease: A Comparison of the Cognitive and Clinical Profiles
Authors: Sadiq Dilman , Whitfield Tim , Lee Lean , Stevens Tim , Costafreda Sergi , Walker Zuzana 
Published: April 2017

Background: Dementia must be diagnosed accurately and early in the disease course to allow pathology-specific treatments to be effective. Dementia with Lewy bodies (DLB) is often misdiagnosed as Alzheimer’s disease (AD), especially at the prodromal stage. Objective: To compare the clinical and neuropsychological profiles of Mild Cognitive Impairment (MCI) patients who, at follow-up, progressed to AD (retrospectively AD-MCI) or DLB (retrospectively DLB-MCI) or remained MCI. Methods: This longitudinal study used an unselected sample from a memory clinic database. A total of 1,848 new patients were seen at the memory clinic between 1994–2015. Of these, 560 patients (30%) had an initial diagnosis of MCI and were considered for the study. Inclusion criteria were patients who had a diagnosis of MCI at initial assessment and a minimum of 12 months’ follow-up. Results: Of the 429 MCI patients with follow-up data, 164 (38%) remained MCI, 107 (25%) progressed to AD, and 21 (5%) progressed to DLB. The remainder progressed to alternative diagnoses. At baseline, DLB-MCI patients performed significantly worse on visuospatial function and letter fluency tests than both AD-MCI and stable-MCI groups, and better on episodic memory tests than the AD-MCI group. At baseline, DLB-MCI patients had a significantly higher mean UPDRS score and were more likely to have REM sleep behavior disorder and fluctuating cognition. Conclusion: DLB-MCI patients have a specific cognitive and neuropsychiatric profile which should alert clinicians to the possibility of prodromal DLB. This is relevant when considered in the context of early disease-specific therapy.
Modifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA Index
Authors: Vos Stephanie J.B. , van Boxtel Martin P.J. , Schiepers Olga J.G. , Deckers Kay , de Vugt Marjolein , Carrière Isabelle , Dartigues Jean-François , Peres Karine , Artero Sylvaine , Ritchie Karen , Galluzzo Lucia , Scafato Emanuele , Frisoni Giovanni B. , Huisman Martijn , Comijs Hannie C. , Sacuiu Simona F. , Skoog Ingmar , Irving Kate , O’Donnell Catherine A. , Verhey Frans R.J. , Visser Pieter Jelle , Köhler Sebastian 
Published: April 2017

Background: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual’s prevention potential for dementia. Objective: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. Methods: 9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual’s LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1–16). Results: In midlife (55–69 y, n = 3,256) and late life (70–79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80–97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia. Conclusion: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.