bluuebunny/crossref_metadata_2025_split huggingface dataset:
Varactor‐tuned bandpass filter using a microstrip stepped‐impedance combline filter and a new J‐inverter
Authors: Hoseinabadi Abbas , Bagher Tavakoli Mohammad , Rastegar Fatemi Mohammad Jalal , Setoudeh Farbod 
Published: September 2024

AbstractThe stepped‐impedance combline band pass filter (BPF) with novel input and output networks based on a new proposed J‐inverter, which increases the center frequency tuning range with constant bandwidth (BW), is discussed. The even and odd mode analysis shows that the stepped resonators provide the necessary conditions for the appropriate coupling coefficient to keep the BW constant. In order to create an appropriate quality factor, the new proposed J‐inverter is used. In the frequency response of the stopband region, three transition zeros (TZs) are generated, which two of TZs are controllable. The proposed tunable BPF has been fabricated on RO4003 substrate with a dielectric constant of 3.38 and 0.813 mm thickness. The size of the filter is compact and is only
, where
is the guided wavelength at the lower center frequency. The center frequency is equal to 1.723 GHz and a frequency tuning range from 1.2 GHz to 2.246 GHz with 100 MHz constant 3 dB absolute BW, the insertion loss of 1.4–3.17 dB and return loss of 17.8–25.9 dB is achieved.
NY‐ESO‐1 antigen: A promising frontier in cancer immunotherapy
Authors: Alsalloum Alaa , Shevchenko Julia A. , Sennikov Sergey 
Published: September 2024

AbstractSignificant strides have been made in identifying tumour‐associated antigens over the past decade, revealing unique epitopes crucial for targeted cancer therapy. Among these, the New York esophageal squamous cell carcinoma (NY‐ESO‐1) protein, a cancer/testis antigen, stands out. This protein is presented on the cell surface by major histocompatibility complex class I molecules and exhibits restricted expression in germline cells and various cancers, marking it as an immune‐privileged site. Remarkably, NY‐ESO‐1 serves a dual role as both a tumour‐associated antigen and its own adjuvant, implying a potential function as a damage‐associated molecular pattern. It elicits strong humoural immune responses, with specific antibody frequencies significantly correlating with disease progression. These characteristics make NY‐ESO‐1 an appealing candidate for developing effective and specific immunotherapy, particularly for advanced stages of disease. In this review, we provide a comprehensive overview of NY‐ESO‐1 as an immunogenic tumour antigen. We then explore the diverse strategies for targeting NY‐ESO‐1, including cancer vaccination with peptides, proteins, DNA, mRNA, bacterial vectors, viral vectors, dendritic cells and artificial adjuvant vector cells, while considering the benefits and drawbacks of each strategy. Additionally, we offer an in‐depth analysis of adoptive T‐cell therapies, highlighting innovative techniques such as next‐generation NY‐ESO‐1 T‐cell products and the integration with lymph node‐targeted vaccines to address challenges and enhance therapeutic efficacy. Overall, this comprehensive review sheds light on the evolving landscape of NY‐ESO‐1 targeting and its potential implications for cancer treatment, opening avenues for future tailored directions in NY‐ESO‐1‐specific immunotherapy.Highlights
Endogenous immune response: NY‐ESO‐1 exhibited high immunogenicity, activating endogenous dendritic cells, T cells and B cells.
NY‐ESO‐1‐based cancer vaccines: NY‐ESO‐1 vaccines using protein/peptide, RNA/DNA, microbial vectors and artificial adjuvant vector cells have shown promise in enhancing immune responses against tumours.
NY‐ESO‐1‐specific T‐cell receptor‐engineered cells: NY‐ESO‐1‐targeted T cells, along with ongoing innovations in engineered natural killer cells and other cell therapies, have improved the efficacy of immunotherapy.
Perspectives on Photocatalytic Paper‐Based Batteries Fueled by Alcohol
Authors: Zanata Cinthia R. , Zapata Maximiliano J. M. , Wender Heberton , Martins Cauê A. 
Published: September 2024

AbstractAmid growing energy demands, innovative solutions are essential to power a variety of devices. Paper‐based microfluidic fuel cells (PμFCs), powered by eco‐friendly alcohols derived from biomass, present a promising option. While lightweight and disposable, they mainly rely on costly noble‐metal catalysts for high efficiency. In this context, the concept of photo paper batteries (pPBs), utilizing affordable sunlight‐activated semiconductors to drive alcohol oxidation on paper, opens the possibility to disposable and affordable energy solutions. Our review highlights recent progress in PμFCs fueled by alcohols like methanol, ethanol, ethylene glycol, and glycerol. We explore semiconductor advancements driving anodic reactions and envision the potential of pPBs. To achieve practical pPBs, refining semiconductors, electrode design, and microfluidic engineering are pivotal. This short review highlights the transformative potential of pPBs and beckons researchers to partake in shaping this new field.
A study on the application of a composite MIL88A(Fe)/TiO2 in a hexagonal photoreactor for phenol removal: Response surface methodology and kinetic modeling
Authors: Nikseresht Mehrazin , Iranshahi Davood , Badiei Alireza 
Published: September 2024

AbstractThe application of a novel composite MIL88A(Fe)/TiO2 for phenol removal in a new hexagonal photoreactor design was investigated. The unique hexagonal shape of the reactor increases the surface area available for irradiation, leading to more efficient removal of contaminants. The composite was characterized using X ray diffraction (XRD), Fourier transform‐infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) images to determine its properties. Photocatalyst dosage, reaction time, phenol concentration, pH, and mL H2O2/L PW (phenol wastewater) were chosen as effective parameters on the process. To plan an experiment and maximize phenol removal, the response surface methodology (RSM) was applied. Ideal conditions for optimum efficiency (95.96%) include initial phenol concentration of 58 mg/L, pH of 7.51, reaction time of 68.61 min, mL H2O2/L PW of 0.18, and catalyst dosage of 0.4 g/L PW. Trapping experiments prove that ˙O2 and ˙OH produced in Fenton and photocatalytic processes are the predominant active radicals in this process. The kinetics was fitted with the first‐order, second‐order, n‐order, and Langmuir–Hinshelwood models using nonlinear least squares techniques. The n‐order model with n = 0.54 was found to be the most suitable model (R2 0.998), with a model constant of k = 0.11 (mol0.46/L0.46.s).
Coral reefs‐like shape AgI/polypyrrole nanocomposite through the intercalation of iodide ions in the network for optoelectronic applications
Authors: Rabia Mohamed , Elsayed Asmaa M. , Aldosari Eman , Abdelazeez Ahmed Adel A. 
Published: September 2024

AbstractA promising optoelectronic device for light sensing in both the UV and Vis regions is fabricated. This device consists of a nanocomposite resembling coral reefs, termed AgI/polypyrrole‐iodide (AgI/Ppy‐I). The resulting nanocomposite exhibits a hierarchical structure wherein larger particles, comprising smaller particles ~45 nm and an optical bandgap measuring 2.4 eV, form a coral reef‐like morphology. The sensitivity estimation of this constructed optoelectronic device relies on evaluating the current density (Jph) values. Under illumination, a remarkable augmentation in current density (Jph = 0.46 mA cm−2) with a promising value compared to the dark condition's 0.12 mA cm−2. The optical characteristics of this nanocomposite make it highly conducive to efficient UV–Vis light sensing. The values of D (detectivity), reflecting the device's sensitivity, are notably high at 4 × 108 and 3.82 × 108 Jones in the UV and Vis regions, correspondingly. The potential of this photodetector is reinforced by the computed R‐values, which denote the device's responsivity. With values of 1.8 and 1.72 mA W−1 across these two optical regions, correspondingly, it showcases the nanocomposite's effectiveness in transforming incident light into electrical current. Moreover, the appeal of this photodetector extends beyond its performance characteristics. Its cost‐effectiveness, eco‐friendliness, straightforward preparation methodology, scalability for mass production, and high stability collectively. The versatility of this material, coupled with its advantageous attributes, opens avenues for its widespread application, catering to the diverse needs of industries and contributing to the accessibility of efficient optoelectronic devices for a broader audience.
Experimental study on stepped solar still equipped with reflectors for the concentration of sugarcane juice
Authors: Grewal Rahul , Kumar Mahesh , Chaudhary Ashok , Yadav Pankaj 
Published: September 2024

AbstractThe present study accentuate the noteworthiness of ongoing research in evolving sustainable sugarcane juice evaporation technologies to help the non‐centrifugal sugar (NCS) industry. Concentrated sugarcane juice (CSJ) is the raw material for the production of variety of value added products. A stepped solar still (SSS) could be one of the inexpensive solutions to evaporate water from sugarcane juice. In this study, a SSS having internal and external reflectors (SSS‐IR‐ER) is tested at 25 mL/min of sugarcane juice for obtaining CSJ. The thermo‐enviro‐economic performance of SSS‐IR‐ER unit is compared with SSS and SSS‐IR (SSS having internal reflectors) units. The final brix content (oB) of the CSJ obtained from SSS‐IR‐ER is found to be maximum (20.7 oB) which is respectively, 16.90% and 7.25% higher than those of SSS and SSS‐IR units. The total distillate output (condensate) and heat transfer coefficients show similar trends as that of brix values, which proves thermal dominance of SSS‐IR‐ER unit. For SSS‐IR‐ER, the convective and evaporative heat transfer coefficients were found to be maximum as 3.89 and 73.78 W/m2°C, respectively. The average values of energy and exergy efficiencies for SSS‐IR‐ER were, respectively, evaluated as 55.25% and 2.7% which were also observed maximum among the tested units. SSS‐IR‐ER also found to command in environmental and economic aspects with maximum values of total productive cost ($0.218), CO2 mitigation (14.93 tonnes) and carbon credit earned ($186.73). It is inferred that SSS‐IR‐ER is more economical and thermally efficient than SSS and SSS‐IR units.
Determining pore size distribution in rocks using shear‐thinning fluids: Utilisation of the method in geomorphology
Authors: Slavík Martin , Lanzendörfer Martin , Maľa Martin , Weiss Tomáš 
Published: September 2024

AbstractThe pore space characteristics of geological materials are closely related to their mechanical, transport and hydraulic properties. In geomorphology, pore size distribution (PSD) is an important characteristic in rock weathering, evaporation and other studies. In an effort to find novel methods to determine the PSD, perhaps to bypass the disadvantages of the current techniques, there has been a growing interest in the use of non‐Newtonian fluids. In this contribution, we are particularly interested in the method recently introduced by Abou Najm and Atallah (the ANA method), which exploits the way in which the flow of different shear‐thinning fluids distributes differently in the pore space to compute the functional PSD estimation. We performed a set of saturated flow experiments with aqueous xanthan gum solutions of different concentrations, using as simple as possible laboratory settings, and we implemented a modified version of the previously introduced numerical model to obtain the PSDs of four sandstone and one tuff samples. The results are compared with conventional mercury intrusion porosimetry, showing a good agreement regarding the dominant pore size and a notable similarity in the distributions. Several limitations were identified as well, such as the lack of information on relatively small pores (<5–10 μm for the samples studied) and the potential issues in obtaining a more detailed distribution. We conclude that the ANA method is promising for geomorphological evaporation and rock durability studies, particularly for coarser materials such as sandstone, but it also encounters challenges for certain applications, especially for fine‐grained rocks. It must be acknowledged that the ANA method has been tested on a limited range of materials and further investigation is required to fully explore its capabilities and limitations.
Are mesopelagic organisms nutritious food? Impact on metabolism, availability of nutrients, and contaminants from dietary intervention in C57BL/6J mice model
Authors: Azad Atabak M. , Myrmel Lene Secher , Wiech Martin , Nøstbakken Ole Jakob , Fjære Even , Lundebye Anne‐Katrine , Ho Quang Tri , Madsen Lise 
Published: September 2024

AbstractMesopelagic species are unexplored novel low‐trophic sources of essential micronutrients and may contribute to combat malnutrition. In this study, common mesopelagic species from the North Sea including Northern krill (Meganyctiphanes norvegica), glacier lanternfish (Benthosema glaciale), and Muller's pearlside (Maurolicus muelleri) were supplemented in mice feed using a Western diet recipe. The metabolic outcomes were subsequently compared to those of ordinary seafood. Consumption of mesopelagic species induced a large variation in weight gain, in the following order: lanternfish (7.1 g) > krill (14.4 g) > control (19.7 g) > pearlside (22.6 g). The lanternfish‐supplemented diet containing wax esters reduced weight gain and obesity and improved insulin sensitivity. The wax esters from the lanternfish‐supplemented diet were efficiently absorbed, with more than 92% of the fatty alcohols being assimilated. The inclusion of lanternfish and pearlside led to improvements in the fatty acid (FA) composition in the mouse liver, evidenced by increased levels of essential long‐chain polyunsaturated FAs and an increased n‐3/n‐6 ratio (0.7 to 1.45 vs. 0.46 in control group). Notably, no adverse effects were found in mice fed pearlside and lanternfish, although an elevated level of fluoride in femur bone was observed in mice fed a diet supplemented with krill followed by reduced sperm concentration and sperm motility. Collectively, our findings underscore the diverse array of metabolic and physiological effects induced by the consumption of mesopelagic species. Furthermore, these species can be considered as good sources of n‐3 FAs and essential vitamins, suggesting their potential value to human nutrition.
Cyanidin‐3‐O‐glucoside magic: Unveiling the power to inhibit cholesterol absorption via the intestinal farnesoid X receptor–bile acids pathway with Lactobacillus Marvel
Authors: Wang Sihang , Li Bin , Tan Hui , Sun Xiyun , Tian Jinlong , Li Shuying , Xu Yongping , Bian Yuanyuan , Wang Yuehua 
Published: September 2024

AbstractCyanidin‐3‐O‐glucoside (C3G), an abundant and widely utilized anthocyanin monomer, has been shown to significantly inhibit cholesterol absorption. Building on our previous research demonstrating the role of Lactobacillus as a specific intestinal microflora associated with C3G‐mediated cholesterol absorption inhibition, the present study aimed to evaluate the inhibitory effects of C3G on high‐fat diet–induced cholesterol absorption. Results indicate that C3G significantly reduced total cholesterol and triglyceride levels while suppressing red grease formation in Caco‐2 cells. In vivo, C3G ameliorated blood lipid levels and mitigated small intestinal damage, as evidenced by restored villus length and basal thickness. Additionally, C3G upregulated intestinal farnesoid X receptor (FXR) mRNA expression and inhibited the expression of key cholesterol absorption proteins, Niemann‐Pick C1‐Like 1 and acetyl‐CoA acetyltransferase 2. Furthermore, C3G increased short‐chain fatty acid content and activated ileal bile acid‐binding protein expression. C3G also inhibited intestinal bile acid (BA) reabsorption, promoted fecal BA excretion, and obstructed cholesterol emulsification. Moreover, C3G modulated gut microbiota abundance and diversity, increasing the abundance of Akkermansia, Bifidobacterium, Coprococcus, Ruminococcus, and Butyricicoccus. In conclusion, our findings suggest that C3G inhibits cholesterol absorption by reshaping intestinal flora composition and regulating the FXR‐BAs axis. This study provides a theoretical foundation for the use of C3G as a raw material for inhibiting cholesterol absorption.
Insights into phytochemistry and bioactive potential of saffron (Crocus sativus L) petal
Authors: Qadir Mir Minha , Nissar Jasia , Dar Aamir Hussain , Ganaie Tariq Ahmad , Bashir Mahrukh 
Published: September 2024

AbstractThe principal by‐product of saffron processing, which is produced at a large level but has little market value, is saffron petals. Numerous constituents with profound bioactive potential, including safranal, crocin, picrocin, anthocyanins, glycosides, alkaloids, and kaempferol, are present in saffron petals. Saffron petal is an appropriate substitute for a variety of uses because it is less expensive and produced in greater quantities than saffron stigma. In this review, many pharmaceutical characteristics of the saffron petal have been discussed, including its anti‐bacterial, antifungal, antispasmodic, immunomodulatory, antidepressant, antinociceptive, hepatoprotective, renoprotective, antihypertensive, antidiabetic, and antioxidant activity. This review also provides insight into the pharmacological characteristics of saffron and its components along with the related mechanisms of action.
A Comparative Review on Carbon Nanomaterials and Their Impact on Plant Growth With the Lens of Green Chemistry Principles
Authors: Peng Wei , Li Peng , Zia Muhammad , Bhuiyan Shamsul A. , Liu Yiyi , Chen Dechao , Tudi Muyesaier , Gao Yongsheng , Yan Xuecheng , Jia Yi , Li Qin 
Published: September 2024

AbstractCarbon nanomaterials (CNMs), comprising carbon dots, graphene‐related materials, and carbon nanotubes, have significant potential for enhancing agricultural productivity. Their compositional compatibility and exceptional properties intrigue a great deal of explorations in agricultural applications, such as fertilizers, pesticides, and regulators of plant growth. However, the evaluation of their agricultural applicability often lacks quantitative sustainability metrics, with insufficient scrutiny on the carbon footprint and scalability of the manufacturing. This review attempts to provide a quantitative ranking system for evaluating the manufacturing processes of the CNMs by applying the twelve principles of Green Chemistry, particularly in the context of agriculture applications. The review also offers a systematically organized account of CNMs' effects on plant systems, encompassing nutrient enhancement, photosynthesis, soil amelioration, disease resistance, and phytotoxicity, which can provide design rationales for the further development of CNMs.
Beyond complete remission: A comparative analysis of long‐term laryngeal function in patients with hypopharyngeal and laryngeal cancer following radiotherapy and concurrent chemoradiation
Authors: Huh Gene , Chung Eun‐Jae , Kim Won Shik , Kwon Seong Keun , Sung Myung‐Whun , Keam Bhumsuk , Wu Hong‐Gyun , Lee Joo Ho , Kim Jin Ho , Ahn Soon‐Hyun 
Published: September 2024

AbstractBackgroundThis study evaluates functional larynx preservation in patients with hypopharyngeal cancer (HPC) and laryngeal cancer (LC) who achieved complete remission following radiotherapy (RT) or concurrent chemoradiation (CCRT).MethodsHPC and LC patients treated with RT/CCRT from 1999 to 2017 were retrospectively analyzed. Severe late dysphagia and tracheostomy cases were assessed to determine laryngeal function. Long‐term preservation rate of functional larynx and associated factors were evaluated.ResultsOf 152 patients (55 HPC, 97 LC), nine developed severe dysphagia, occurring on average 58.2 months post‐treatment. HPC and cervical node metastasis significantly increased the risk of laryngeal function impairment (p < 0.001 and p = 0.014, respectively), presenting a continued decline in functional larynx preservation rate beyond 10 years.ConclusionsPatients with HPC and cervical node metastasis demonstrate an increased risk for long‐term laryngeal function impairment despite successful oncologic outcomes. This risk extends beyond 10 years, underscoring the need for prolonged monitoring and comprehensive support.
Clinical presentations and dispositions of transient ischemic attack and minor stroke patients at the emergency department of a tertiary hospital in southern Thailand: A retrospective study
Authors: Sakarin Tanawin , Liabsuetrakul Tippawan 
Published: September 2024

AbstractObjectiveTo assess the dispositions, management, and clinical outcomes of TIAMS patients in ED to improve the quality of management in ED.Material and MethodA descriptive retrospective study was conducted in ED patients aged >18 years diagnosed with TIAMS in the ED from 1 January 2018, to 31 January 2019. Data regarding terms of clinical presentation, examination, management, disposition, and adverse events were collected.ResultsThree hundred and sixty‐three TIAMS patients were enrolled in the study. Majority of the patients aged <45 years were admitted or referred (15.4%). The highest proportion of patients whose onset times from the last normal were less than 4.5 h were admitted to the EDOU (55.6%), while all patients whose onset times from the last normal were more than 48 h were discharged. Patients with abnormal cerebellar signs or atrial fibrillation were less likely to be discharged from the hospital. Patients with lower National Institutes of Health Stroke Scale (NIHSS) and ABCD2 scores tended to be discharged.ConclusionAmong TIAMS patients, age, symptom onset, presence of atrial fibrillation, positive cerebellar signs, and severity scores influenced the disposition. There was no difference in adverse events among disposition groups.
A narrative review on advances in neoadjuvant immunotherapy for esophageal cancer: Molecular biomarkers and future directions
Authors: Wang Wenjing , Ye Lisha , Li Huihui , Chen Wei , Hong Wei , Mao Weimin , Xu Xiaoling 
Published: September 2024

AbstractEsophageal cancer has a poor prognosis and survival rate due to its high incidence in Asia, lack of early symptoms and limited treatment options. In recent years, many clinical trials have demonstrated that immunotherapy has greatly improved the survival of patients with esophageal cancer. In addition, the combination of neoadjuvant immunotherapy with other popular therapeutic regimens has shown good efficacy and safety. In this review, we summarize the progress of clinical trials and some breakthroughs in neoadjuvant immunotherapy for esophageal cancer in recent years and suggest the possibility of multimodal neoadjuvant immunotherapy regimens, as well as directions for future development.