bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute middle cerebral artery occlusion due to a small internal carotid aneurysm cavity with blood stagnation: illustrative case
Authors: Uezato Minami , Ikeda Hiroyuki , Kimura Genki , Osuki Takuya , Yokochi Yasunori , Kinosada Masanori , Kurosaki Yoshitaka , Chin and Masaki 
Published: October 2024

BACKGROUND
In cerebral large vessel occlusion, even when an aneurysm is close to the target vessel, if the aneurysm is relatively small and angiography shows no thrombus within the aneurysm, it is difficult to identify the aneurysm as the embolic source.

OBSERVATIONS
A 67-year-old man with a history of two left-sided cerebral infarctions developed a small left-sided cerebral infarction. On hospital day 3, he developed a left M2 occlusion and underwent thrombectomy with retraction of a stent retriever into an aspiration catheter at the proximal end of the thrombus. A red thrombus was retrieved, and M2 recanalization was successfully achieved. Angiography revealed a large partially thrombotic aneurysm with a small cavity with blood stagnation in the left cervical internal carotid artery, which was considered the embolic source. Stent-assisted coil embolization was performed on the aneurysm, and no recurrent cerebral infarction was observed after embolization.

LESSONS
In cerebral large vessel occlusion, an aneurysm cavity with blood stagnation may be the embolic source. Using an aspiration catheter alone or retracting a stent retriever into an aspiration catheter could be a useful technique and help to avoid interference between the aneurysm and the stent retriever.
https://thejns.org/doi/10.3171/CASE24406
Spontaneous regression of a petroclival meningioma: illustrative case
Authors: Noda Ryuichi , Kawashima Mariko , Akabane Atsuya , Inoue Tomohiro 
Published: October 2024

BACKGROUND
Spontaneous regression is relatively rare in meningiomas. Since meningiomas are known to have a relationship with sex-related hormones, spontaneous regression cases related to sex hormones have been reported.

OBSERVATIONS
A 66-year-old man with a petroclival meningioma was radiologically followed up for 13 years. The tumor initially measured 2.535 cm3 and 2.521 cm3 on gadolinium-enhanced magnetic resonance imaging (MRI) and fast imaging employing steady-state acquisition MRI, respectively. However, the measurements decreased in the follow-up period to 0.977 cm3 and 0.98 cm3, respectively, demonstrating spontaneous regression of an asymptomatic meningioma located in a petroclival area. Continuous meticulous long-term follow-up revealed this phenomenon.

LESSONS
It is important to retain the option of conservative treatment for patients ineligible for surgery for reasons such as advanced age and coexisting diseases.
https://thejns.org/doi/10.3171/CASE24416
ВИКОРИСТАННЯ МОДЕЛЕЙ ЕКОНОМІЧНОГО ЗРОСТАННЯ ДЛЯ ОБҐРУНТУВАННЯ СТАЛОГО РОЗВИТКУ ПІДПРИЄМСТВ МОРЕГОСПОДАРСЬКОГО КОМПЛЕКСУ
Authors: Girina O.B. , Merkt O.V. , Zagorodnia K.O. 
Published: October 2024

Вступ. У досліджених роботах визначена модель Р. Солоу як базова та оптимальна для моделювання розвитку підприємств України в умовах посткризового відновлення. Мета. Ця стаття розглядає аналіз інвестиційної діяльності підприємства через призму моделей економічного зростання на прикладі розвитку державного підприємства «Морський торговельний порт Південний». Для виконання цього завдання використовується виробнича функція Кобба-Дугласа. Результати. Досліджено відображення науково-технічного прогресу в моделях економічного зростання, роль різних факторів у зростанні продуктивності праці. Детально проаналізовано моделі економічного зростання та продемонстровано можливий їхній вплив на діяльність морських торговельних портів. На підставі функції Кобба-Дугласа, розрахованої для компанії ДП «МТП Південний», розглядаються умови сталого розвитку підприємства. Аналізується коефіцієнт нейтрального технічного прогресу, рівноважна норма капіталовкладень. Для включення в модель Соллоу побудована функція Кобба-Дугласа для продуктивності ефективної праці. Був виконаний аналіз факторів вартості основних виробничих фондів (ОВФ) та чисельності робітників на темп приросту продуктивності праці за звітні роки з урахуванням як екстенсивного, так і інтенсивного їх впливу. Доведено, що у звітному періоді компанії темпи приросту доходу, які дорівнюють темпам приросту виробничих фондів, свідчать про наявність рівноважного розвитку підприємства. З’ясоване співвідношення між середньою та граничною продуктивністю чисельності та капіталу. Граничний аналіз факторів росту чистого доходу показав, що фондовіддача ДП «МТП Південний» не змінюється за розглянутий період та дорівнює граничній продуктивності основних виробничих фондів, тоді як середня та гранична продуктивність праці коливається по роках. Це також свідчить про те, що розвиток ДП «МТП Південний» має риси науково-технічного прогресу за Харродом. Висновки. Розглядаються можливість сталого розвитку ДП МТП «Південний» за умов додержання у своєму розвитку встановленої рівноважної норми капітальних вкладень.
Subsurface Geosciences Learning in Virtual Reality: A Case Study in Central Luconia Province, Malaysia
Authors: Jiménez Grisel , Latiff Abdul Halim , Schulze Katja 
Published: October 2024

The recent proliferation of Extended Reality (XR) applications in geoscience education and research has opened new avenues for the enhanced visualization and analysis of the Earth’s geodata. This study specifically explores the benefits for teaching when supplementing industry standard software packages, such as Paleoscan, Petrel, and JewelSuite, with 3D visualization in XR. The teaching focuses on but is not limited to an understanding of subsurface seismic and well data. During this study, the undergraduate Petroleum Geoscience students transitioned from 2D computer screen visualizations to immersive XR tools. The dataset selected for teaching focuses on the subsurface carbonate EX field in the South China Sea. The EX-field in Central Luconia is located 100–300 km from Sarawak’s coastline in water depths of 60–140 m. It includes a post-stacked time- 3D seismic cube linked to wells, allowing students to work with seismic data, adjust scales, and conduct preliminary seismic analysis. The findings revealed a significant improvement in respondents’ skills in comprehending and analysing seismic and core data, enhancing the overall learning experience in Petroleum Geoscience. This paper also examines the students’ feedback on their learning experiences during virtual subsurface visualization throughout their university degree in geoscience. For evaluating learning success, we used an approach that merges quantitative and qualitative data, The students’ perceptions were assessed through anonymous quantitative surveys and questions. The analysis of student responses emphasizes the valuable learning experience offered by 3D virtual environments designed for realistic first-person navigation and freedom of movement, like a real field experience. The results highlight the potential of virtual subsurface visualization for imparting essential skills to geosciences.
Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of AD
Authors: Lee Hyun-ju , Hwang Jeong-Woo , Kim Jieun , Jo A-Ran , Park Jin-Hee , Jeong Yoo Joo , Jang Ji-Yeong , Kim Su-Jeong , Song Jeong-Heon , Hoe Hyang-Sook 
Published: October 2024

IntroductionErlotinib is an epidermal growth factor receptor (EGFR) inhibitor that is approved by the FDA to treat non-small cell lung cancer (NSCLC). Several membrane receptors, including EGFR, interact with amyloid β (Aβ), raising the possibility that erlotinib could have therapeutic effects on Alzheimer's disease (AD). However, the effects of erlotinib on Aβ/tau-related pathology and cognitive function in mouse models of AD and its mechanisms of action have not been examined in detail.MethodsTo investigate the effects of erlotinib on cognitive function and AD pathology, 3 to 6-month-old PS19 mice and 3 to 3.5-month-old 5xFAD mice and WT mice were injected with vehicle (5% DMSO + 10% PEG + 20% Tween80 + 65% D.W.) or erlotinib (20 mg/kg, i.p.) daily for 14 or 21 days. Then, behavioral tests, Golgi staining, immunofluorescence staining, western blotting ELISA, and real-time PCR were conducted.Results and discussionWe found that erlotinib significantly enhanced short-term spatial memory and dendritic spine formation in 6-month-old P301S tau transgenic (PS19) mice. Importantly, erlotinib administration reduced tau phosphorylation at Ser202/Thr205 (AT8) and Thr231 (AT180) and further aggregation of tau into paired helical fragments (PHFs) and neurofibrillary tangles (NFTs) in 3-month-old and/or 6-month-old PS19 mice by suppressing the expression of the tau kinase DYRK1A. Moreover, erlotinib treatment decreased astrogliosis in 6-month-old PS19 mice and reduced proinflammatory responses in primary astrocytes (PACs) from PS19 mice. In 3- to 3.5-month-old 5xFAD mice, erlotinib treatment improved short-term spatial memory and hippocampal dendritic spine number and diminished Aβ plaque deposition and tau hyperphosphorylation. Furthermore, erlotinib-treated 5xFAD mice exhibited significant downregulation of astrocyte activation, and treating PACs from 5xFAD mice with erlotinib markedly reduced cxcl10 (reactive astrocyte marker) and gbp2 (A1 astrocyte marker) mRNA levels and proinflammatory cytokine mRNA and protein levels. Taken together, our results suggest that erlotinib regulates tau/Aβ-induced AD pathology, cognitive function, and Aβ/tau-evoked astrogliosis and therefore could be a potent therapeutic drug for ameliorating AD symptoms.
Case report: target antigen and subclass switch in a patient with autoimmune nodopathy
Authors: Appeltshauser Luise , Glenewinkel Helena , Rohrbacher Sophia , Wessely Lena , Villmann Carmen , Sommer Claudia , Doppler Kathrin 
Published: October 2024

IntroductionAutoimmune nodopathy (AN) is a new entity in the field of peripheral neuropathies and is defined by the presence of auto-antibodies against structures of the node of Ranvier combined with specific clinico-pathophysiological features and therapy response in affected patients. The target-specific antibodies do not only serve as diagnostic biomarkers but also for treatment evaluation during follow-up.Case reportWe report a 66-year-old female patient with various autoimmune diseases, including a history of membranous glomerulonephritis which presented with acute-onset, sensorimotor tetraparesis, cranial nerve involvement, and mild respiratory insufficiency. Under the suspicion of Guillain–Barré syndrome, she received intravenous immunoglobulins (IVIg) and achieved remission. At 8 months later, she relapsed with now a poor response to IVIg and developed additional features such as severe sensory ataxia, tremor, and neuropathic pain. Anti-contactin-1 IgG2 antibodies were detected, and the diagnosis was reverted to AN. Plasma exchange and rituximab treatment led to a serological remission and corresponding significant clinical improvement, and the therapy was paused. At 2 years after symptom onset, her condition worsened again with sensorimotor symptoms and severe neuropathic pain despite seronegativity for contactin-1. However, serum binding assays to teased nerve fiber staining showed recurring antibody reactivity against paranodal structures. Caspr-1 was identified as a new target antigen via cell-based assay, and high-titer antibodies of the IgG4 subclass were confirmed via ELISA. Hence, a new cycle of plasma exchange and regular rituximab treatment was initiated, with subsequent clinical improvement and serological remission. The serum neurofilament light chain (sNFL) levels were assessed retrospectively and rose and fell together with the antibody titer.DiscussionThis case demonstrates that autoimmunity to (para)nodal structures can reoccur especially in patients prone to autoimmune disorders and can switch its target antigen and subclass in the course of disease. The presence of auto-antibodies against different targets at the node of Ranvier has direct implications for therapeutic management. We suggest a close follow-up of patients with AN after successful therapy. In case of deterioration despite seronegativity, non-specific tests such as teased fiber assays and repeated screening for different target antigens should be considered.
Smartphone three-dimensional imaging for body composition assessment using non-rigid avatar reconstruction
Authors: Tinsley Grant M. , Rodriguez Christian , Florez Christine M. , Siedler Madelin R. , Tinoco Ethan , McCarthy Cassidy , Heymsfield Steven B. 
Published: October 2024

BackgroundModern digital anthropometry applications utilize smartphone cameras to rapidly construct three-dimensional humanoid avatars, quantify relevant anthropometric variables, and estimate body composition.MethodsIn the present study, 131 participants ([73 M, 58 F] age 33.7 ± 16.0 y; BMI 27.3 ± 5.9 kg/m2, body fat 29.9 ± 9.9%) had their body composition assessed using dual-energy X-ray absorptiometry (DXA) and a smartphone 3D scanning application using non-rigid avatar reconstruction. The performance of two new body fat % estimation equations was evaluated through reliability and validity statistics, Bland–Altman analysis, and equivalence testing.ResultsIn the reliability analysis, the technical error of the measurement and intraclass correlation coefficient were 0.5–0.7% and 0.996–0.997, respectively. Both estimation equations demonstrated statistical equivalence with DXA based on ±2% equivalence regions and strong linear relationships (Pearson’s r 0.90; concordance correlation coefficient 0.89–0.90). Across equations, mean absolute error and standard error of the estimate values were ~ 3.5% and ~ 4.2%, respectively. No proportional bias was observed.ConclusionWhile continual advances are likely, smartphone-based 3D scanning may now be suitable for implementation for rapid and accessible body measurement in a variety of applications.
Transfer of beef bacterial communities onto food-contact surfaces
Authors: Guron Giselle K. P. , Cassidy Jennifer M. , Chen Chin-Yi , Paoli George C. 
Published: October 2024

IntroductionFood spoilage and pathogenic bacteria on food-contact surfaces, especially biofilm-forming strains, can transfer to meats during processing. The objectives of this study were to survey the bacterial communities of beef cuts that transfer onto two commonly used food-contact surfaces, stainless steel (SS) and high-density polyethylene (HDPE) and identify potentially biofilm-forming strains.MethodsTop round, flank, chuck, and ground beef were purchased from 3 retail stores. SS and HDPE coupons (approximately 2cm × 5cm) were placed on beef portions (3h, 10°C), after which, the coupons were submerged halfway in PBS (24h, 10°C). Bacteria from the beef cuts and coupon surfaces (n = 3) were collected, plated on tryptic soy agar plates and incubated (5 days, 25°C). Bacterial isolates were identified by 16S rRNA gene amplicon sequencing and assayed for biofilm formation using a crystal violet binding (CV) assay (72h, 10°C). Additionally, beef and coupon samples were collected for bacterial community analysis by 16S rRNA gene amplicon sequencing.Results and discussionSixty-one of 972 beef isolates, 29 of 204 HDPE isolates, and 30 of 211 SS isolates were strong biofilm-formers (Absorbance&gt;1.000 at 590 nm in the CV assay). Strong-binding isolates identified were of the genera Pseudomonas, Acinetobacter, Psychrobacter, Carnobacterium, and Brochothrix. Coupon bacterial communities among stores and cuts were distinct (p &lt; 0.001, PERMANOVA), but there was no distinction between the communities found on HDPE or SS coupons (p &gt; 0.050, PERMANOVA). The bacterial communities identified on the coupons may help determine the communities capable of transferring and colonizing onto surfaces, which can subsequently cross-contaminate foods.
Improving water competency among children on the autism spectrum: the AquOTic randomized controlled trial
Authors: Kemp Erika , Nikahd Melica , Howard Mequeil , Darragh Amy , Crasta Jewel E. 
Published: October 2024

IntroductionThere is a critical need for evidence-based and manualized interventions targeting water competency including swim and water safety skills tailored to meet the needs of children on the autism spectrum, a group that is at a high risk of drowning. This study examined the efficacy of AquOTic—a 10-week occupational therapy-based aquatic intervention to improve water competency among children on the autism spectrum.MethodsA total of 37 children on the autism spectrum (ages 5–9 years) were randomized to a waitlist control group (n = 24) or AquOTic intervention group (n = 37; 28 males). Blinded assessors administered the standardized Water Orientation Test-Alyn (WOTA) 1 and 2 and a Swim Skills Checklist to all participants pre- and post-AquOTic/control. Repeated measures mixed effects models were used to examine intervention effects.ResultsAverage WOTA 1 scores increased significantly after participants received AquOTic (Δ = 5.7; 95% CI: 3.7–7.8;p &lt; 0.001), and average WOTA 2 scores increased significantly after participants received AquOTic (Δ = 9.0; 95% CI: 5.7–12.3;p &lt; 0.001). Average swim skills increased significantly after participants received AquOTic (Δ = 7.6; 95% CI: 5.3, 10.0;p &lt; 0.001).ConclusionOur results highlight the efficacy of AquOTic to improve water competency among children on the autism spectrum. Further research is needed to examine long-term effects, dosage requirements to achieve water competency, and the impact of aquatic therapy on other health outcomes.Clinical Trials Registrationclinicaltrials.gov, NCT05524753.
Impact of active root zone soil potassium levels on cotton yield and fiber quality under no tillage
Authors: Shao Jingjing , Liu Aizhong , Dong Helin , Li Pengcheng , Sun Miao , Feng Weina , Huo Feichao , Zheng Cangsong 
Published: October 2024

IntroductionPotassium deficiency significantly hinders cotton growth and development, adversely affecting yield and fiber quality. Applying potassium fertilizer is a common practice to address potassium deficiency in the soil. However, the effectiveness of potassium fertilizer application depends on the appropriate soil potassium levels in cotton fields.MethodsThis study used a randomized block design with six different soil potassium levels and conducted experiments across 18 micro-zones in the field. This study aimed to investigate the response of cotton yield and quality to different soil potassium levels, to try to clarify the suitable soil potassium levels for cotton growth, so as to provide practical and effective help for determining the amount of potash fertilizer in the cotton field. ResultsThe results showed that the seedcotton yield was increasing, with the soil potassium level increased under no tillage. There was no significant difference among K4, K5, and K6 on seedcotton yield, which were significantly higher than K1 and K2. As soil potassium levels increased, the proportion of autumn boll and the proportion of outer boll also increased, indicating that higher soil potassium levels support the better growth and development of cotton in the middle and late stages, leading to increased boll sets and higher yields. Additionally, the available potassium content in the 0–40-cm soil layer was significantly correlated with yield and yield parameters but not with fiber quality indices.DiscussionIt is concluded that K4 treatment could provide sufficient potassium to meet the growth and development needs of cotton. Potassium fertilizer application is recommended when the available potassium content in the 0–40-cm soil layer falls below 122.88 mg kg-1 in the cotton field.
Telehealth regulating together pilot trial: emotion regulation intervention for autistic children and adolescents
Authors: Coffman Marika , Wells Miranda , Schmitt Lauren M. , Reisinger Debra L. , Horn Paul S. , Shaffer Rebecca C. 
Published: October 2024

IntroductionAutistic children and adolescents frequently experience emotion dysregulation, or difficulties with appropriately modifying their emotional reactions. Caregivers of autistic teens frequently seek psychotherapy support for navigating challenges associated with emotion dysregulation. During the COVID-19 pandemic, access to clinical services became limited, with interventions halted or transitioned into a telehealth format.MethodsThis study evaluates the feasibility, acceptability, and initial efficacy of a telehealth adaptation to an existing intervention for emotion dysregulation for children and teens with autism, Regulating Together. A within-subjects trial was conducted for Child (ages 8-12) and Teen groups (ages 13-18). The trial consisted of a 5-week-control lead-in period, a 5-week-intervention, and 5-and 10-weeks-post-intervention follow-ups.ResultsTwenty-eight youth with ASD + ED (n=13 Child and n=15 Teens, 71% male) participated. We observed a 93% retention rate across both groups. Improvements were found in reactivity, irritability, emotion and behavioral regulation, and flexibility immediately post-intervention and 10-weeks post-intervention in both groups. Additional improvements in dysphoria, cognitive regulation, and emotional control were observed in teens.DiscussionOur results suggest promising improvements in ED through telehealth delivery of an emotion regulation intervention in autistic children and adolescents, along with possible improvements in accessibility of this intervention.
The impact of agricultural machinery services on farmland transfer: a analytical perspective based on the profitability of grain production
Authors: Zhang Wenrui 
Published: October 2024

IntroductionIn the context of the deceleration of farmland scale management, a crucial question arises in agricultural development theory and practice: will service driven scale management in the production process become a viable alternative to farmland scale management, serving as the secondary pathway to achieve scale management in China?MethodsTo address this issue, an empirical analysis on the impact of agricultural machinery services on farmland transfer was conducted in this article using data from the China Rural Revitalization Survey database comprising 302 villages and 2,871 micro-farmers in 2020 by utilizing the ordinary least squares method and instrumental variable method.Results and discussionThe results show that the implementation of agricultural machinery services will increase the rate of farmland transfer in villages. The effect of agricultural machinery services on increasing the profitability of large-scale farmers surpasses its effect on smallholder farmers, thereby motivating smallholder farmers to transfer farmland to large-scale farmers, consequently fostering the consolidation of farmland. In addition, power-intensive service links are more effective in increasing the rate of farmland transfer and fostering the concentration of farmland transfer compared to control-intensive service links. The impact of agricultural machinery services on enhancing the rate of farmland transfer and fostering the consolidation of farmland transfer is more pronounced on the plain areas compared to the hillmountainous areas. Consequently, this article demonstrates that service-driven scale management and farmland scale management are not merely alternatives but rather complementary strategies that mutually reinforce each other.