bluuebunny/crossref_metadata_2025_split huggingface dataset:
Azacitidine in Lower-Risk Myelodysplastic Syndromes: A Meta-Analysis of Data from Prospective Studies
Authors: Komrokji Rami , Swern Arlene S. , Grinblatt David , Lyons Roger M. , Tobiasson Magnus , Silverman Lewis R. , Sayar Hamid , Vij Ravi , Fliss Albert , Tu Nora , Sugrue Mary M. 
Published: November 2017

Abstract

Background
After erythropoiesis-stimulating agent (ESA) failure, lenalidomide and hypomethylating agents are the only remaining treatment options for most patients with lower-risk myelodysplastic syndromes (LR-MDS). Optimal choice of these agents as front-line therapy in non-del(5q) LR-MDS is unclear. Because azacitidine clinical data mainly describe experience in higher-risk MDS, we performed a meta-analysis of patient-level data to evaluate azacitidine in patients with red blood cell (RBC) transfusion-dependent LR-MDS.

Materials and Methods
We searched English-language articles for prospective phase II and III azacitidine clinical trials and patient registries published between 2000 and 2015, and Embase abstracts from 2015 conferences. Patient-level data from identified relevant studies were provided by investigators. Meta-analyses followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Efficacy endpoints were RBC transfusion independence (TI) and Clinical Benefit (RBC-TI, erythroid response, and complete or partial remission, per International Working Group 2006 criteria for MDS).

Results
Data for 233 patients from 6 clinical studies and 1 registry study met criteria for inclusion in analyses. Overall, 90.3% of patients had non-del(5q) LR-MDS. Pooled estimates from random-effects models of RBC-TI and Clinical Benefit were 38.9% and 81.1%, respectively; for the ESA-refractory subgroup, they were 40.5% and 77.3%; and for patients with isolated anemia, they were 41.9% and 82.5%. In multivariate analyses, planned use of ≥6 azacitidine treatment cycles was significantly predictive of response.

Conclusion
Azacitidine effects in these patients, most with non-del(5q) LR-MDS, were promising and generally similar to those reported for lenalidomide in similar patients. The choice of initial therapy is important because most patients eventually stop responding to front-line therapy and alternatives are limited.

Implications for Practice
Lower-risk myelodysplastic syndromes (LR-MDS) are primarily characterized by anemia. After erythropoiesis-stimulating agent (ESA) failure, lenalidomide and hypomethylating agents are the only remaining treatment options for most patients. This meta-analysis of 233 azacitidine-treated red blood cell (RBC) transfusion-dependent patients with LR-MDS (92.3% non-del[5q]) from 7 studies showed 38.9% became RBC transfusion-independent. There is no clear guidance regarding the optimal choice of lenalidomide or hypomethylating agents for patients with non-del(5q) LR-MDS following ESA failure. Clinical presentation (e.g., number of cytopenias) and potential outcomes after hypomethylating agent failure are factors to consider when making initial treatment decisions for LR-MDS patients.
Clinical Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in the Diagnostic Algorithm of Advanced Entero-Pancreatic Neuroendocrine Neoplasms
Authors: Rinzivillo Maria , Partelli Stefano , Prosperi Daniela , Capurso Gabriele , Pizzichini Patrizia , Iannicelli Elsa , Merola Elettra , Muffatti Francesca , Scopinaro Francesco , Schillaci Orazio , Salgarello Matteo , Falconi Massimo , Delle Fave Gianfranco , Panzuto Francesco 
Published: November 2017

Abstract

Background
The role of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in the diagnostic algorithm of entero-pancreatic neuroendocrine neoplasms (EP NENs) is unclear because most available data derive from heterogeneous populations in terms of tumor biology and disease status at time of examination. The aim of this study was to determine the ability of 18F-FDG PET to identify patients with more aggressive disease among those with advanced EP NENs.
Subjects, Materials, and Methods . Patients with advanced EP NENs and known disease status (progressive disease [PD] or stable disease [SD]) according to imaging procedures, who received 18F-FDG PET and computed tomography scans during a time frame of 1 month, were included.

Results
A total of 93 patients, including 69 patients with pancreatic NENs and 24 patients with small-intestine NENs, were included. At the time of study entry, 64 patients (68.8%) had PD, and the remaining 29 patients (31.2%) had SD. A total of 62 patients (66.7%) had positive 18F-FDG PET, whereas 18F-FDG PET was negative in the remaining 31 patients (33.3%). Overall, 18F-FDG PET sensitivity and specificity to detect PD were 90.6% and 86.2%, respectively, resulting in a diagnostic accuracy of 89.2%. A positive 18F-FDG PET was significantly associated with PD at the time of study entry (p &lt; .0001 at multivariate analysis). Although a higher proportion of 18F-FDG PET-positive examinations were observed in patients with higher tumor grade (p = .01), 53.8% of patients with grade 1 neuroendocrine tumors (NETs) had positive 18F-FDG PET, and 37.5% of patients with grade 2 NETs had negative 18F-FDG PET. Overall survival was significantly shorter in 18F-FDG PET-positive patients (median: 60 months) in comparison with 18F-FDG PET-negative patients (median not reached; p = .008).

Conclusion
18F-FDG PET has a high diagnostic accuracy to identify progression of disease with unfavorable clinical outcome in patients with advanced EP NENs. Knowledge of disease status and G grading are key factors for physicians to better select patients for whom 18F-FDG PET is clinically useful.

Implications for Practice
The findings of the present study may help physicians dealing with advanced neuroendocrine neoplasms to select patients for whom 18F-fluorodeoxyglucose positron emission tomography is useful to predict poor clinical outcome.
UMA PRAXIS PARA A INCLUSÃO DO OUTRO NA ÓTICA PARADOXAL E NO CAMINHO DOS DIREITOS HUMANOS
Authors: Angelin Rosângela , Hahn Noli Bernado 
Published: November 2017

<p>O tema deste artigo delimita-se ao entendimento da distinção entre racionalidade centrada e racionalidade descentrada, na ótica de Jaques Derrida, possibilitando, a partir dessa distinção, argumentar em favor da racionalidade paradoxal à inclusão do outro e à vivência histórica, contextual, cotidiana, espacial e temporal dos direitos humanos. A questão-problema desta pesquisa é esta: como conceber e como viver os direitos humanos na contemporaneidade para que esses direitos sejam internalizados na vivência dos povos e se tornem cultura? A tese argumentada que se estrutura como resposta à questão formulada é que, para viver os direitos humanos no cotidiano, para concebê-los como direitos possíveis de se tornarem eficazes, há a necessidade de se desconstruir uma racionalidade de perspectiva metafísica, essencialista, monolinguista, etnocentrista e logocentrista, que faz enxergar apenas <em>o</em> sentido em dimensão singular e único, e construir uma racionalidade que faz emergir sentidos múltiplos e diversos a partir de contextos, de lugares e de existências.</p>
Analysis of Agroecology and The Requirement of Supplemental Irrigation on Cacao Plants in Lampung
Authors: Hafif Bariot 
Published: November 2017

<p><em>One of the factors that affect the productivity of cacao plants is water availability. Water deficit will negatively affect the development of cacao flowers and beans. Water stress is reported as one of the causes of low productivity on plantation crops in Lampung Province. The study was aimed to analyze the characteristics of agroecology and supplemental irrigation required for growth and production of cacao in Lampung. The research was carried out in the District of Pesawaran, Tanggamus, East Lampung, and South Lampung, Lampung Province, from 2012 to 2015. The study was conducted with the survey method and literature study for the collection of the primary and secondary data, related to the characteristics of the land agroecology. Geographically, the main cacao growing areas in this region is divided into two regions, western region consist of Pesawaran and Tanggamus District and east region comprise of East Lampung and South Lampung District. Based on agroecological zones, the planting of cacao in both regions is in accordance with the recommendations of land use. However, land suitability analysis showed that some of the agroecological characteristics of land becomes a limiting factor for the growth and production of cacao, including soil pH &lt; 5.5, low cations exchange capacity (CEC) (&lt; 16 cmol(+)/kg), air humidity &gt; 75%, and in some areas there is an erosion hazard. Another obstacle is the water deficit that occurs during 140 days within 1 year of cacao growth cycle that occurred in July until mid-November. There are two factors that can be applied to increase cacao productivity in Lampung province, i.e. (1) an improvement of cacao cultivation technology that can address the characteristics of agroecology as a limiting factor of growth, and (2) an application of a supplemental irrigation technology to avoid cacao from water stress. The requirement of supplemental irrigation is 340.5 mm in western region and 209.7 mm in eastern region of Lampung.</em></p>
AN IN VITRO COST-EFFECTIVE TEST BENCH FOR ACTIVE CARDIAC IMPLANTS, REPRODUCING HUMAN EXPOSURE TO ELECTRIC FIELDS 50 HZ
Authors: Gercek Cihan , Kourtiche Djilali , Nadi Mustapha , Magne Isabelle , Schmitt Pierre , Roth Patrice 
Published: November 2017

Abstract
The European Directive 2013/35/UE sets the minimum requirements for the protection of workers exposed to electromagnetic fields and defines workers bearing implants as workers at particular risk. The European standards 50527-1 and 50527-2-1 propose risk assessments methods for these workers, including numerical and/or experimental in-vitro approaches. This study aims to conceive by using both methods, a cost-effective test bench for active cardiac implants in order to reproduce induced phenomena on a cardiac implant inside a human exposed to 50 Hz electric field, representing exposure up to 100 kV/m, which covers occupational exposure.
TECHNIQUES IN ADVANCING THE CAPABILITIES OF VARIOUS NITRATE DETECTION METHODS: A REVIEW
Authors: Azmi Aizat , Azman Ahmad Amsyar , Ibrahim Sallehuddin , Yunus Mohd Amri Md 
Published: November 2017

Abstract
Strategies to facilitate detection enhancement in various methods of nitrate detection are presented in this paper. The main nitrate detection methods for the past 10 years will be reviewed according to their advantages and disadvantages, followed by a focus on the techniques on increasing detection capabilities. For each detection method, an investigation of the technique of improvement is carried out. The utilisation of advance material such as membranes, reduction agents etc. is also identified as the key aspect for system improvement. Many researchers in the field of potentiometry, electrochemical, and biosensors have focused on miniaturising their detection systems to enhance the capability of nitrate in-situ measurement. The performance of miniaturised sensor systems is comparable to that of conventional systems.
DESIGN AND DEVELOPMENT OF 3D PRINTED MYOELECTRIC ROBOTIC EXOSKELETON FOR HAND REHABILITATION
Authors: Abdallah Ismail Ben , Bouteraa Yassine , Rekik Chokri 
Published: November 2017

Abstract
The development of dynamic rehabilitation devices can be evaluated as a research fastgrowing field. Indeed, robot-assisted therapy is an advanced new technology mainly in stroke rehabilitation. Although patients benefit from this enormous development of technology, including the presence of rehabilitation robots, the therapeutic field still suffering a lack in hand robotic rehabilitation devices. In this context, this work proposes a new design of a 3D printed hand exoskeleton for the stroke rehabilitation. Based on the EMG signals measured from the muscles responsible for the hand motion, the designed mechatronic system detects the intention of hand opening or hand closing from the stroked subject. Based on an embedded controller and five servomotors, the low cost robotic system is able to drive in real time three degrees of freedom (DOFs) for each finger. The real tests with stroked subjects showed that the designed hand exoskeleton architecture has a positive effect on the motion finger range and mainly in the hand ability to perform some simple tasks. The case studies showed a good recovery of the motor functions and consequently the developed system efficiency.
AN INVESTIGATION OF DIFFERENT VIDEO WATERMARKING TECHNIQUES
Authors: Sridhar B. 
Published: November 2017

Abstract
Watermarking is an advanced technology that identifies to solve the problem of illegal manipulation and distribution of digital data. It is the art of hiding the copyright information into host such that the embedded data is imperceptible. The covers in the forms of digital multimedia object, namely image, audio and video. The extensive literature collected related to the performance improvement of video watermarking techniques is critically reviewed and presented in this paper. Also, comprehensive review of the literature on the evolution of various video watermarking techniques to achieve robustness and to maintain the quality of watermarked video sequences.
TRACKING AND AUTOMATING A LIBRARY SYSTEM USING RADIO FREQUENCY IDENTIFICATION TECHNOLOGY
Authors: Alwadi Ali , Kilby Jeff , Gawanmeh Amjad 
Published: November 2017

Abstract
This paper discusses implementing a Location-Aware Library RFID service employing Radio Frequency Identification as a communication technology. Automating a library system with passive RFID tag infrastructure is proven to be feasible, and can be achieved with even distribution of RFID Antennas, well designed RFID network, an appropriate middleware, and a library application with an accurate error function that minimizes the error in the detected location to an acceptable distance, for instance, 35 cm. The paper first discusses the effect of using RFID on the upper application and System layers. A simulation of randomly distributed tags with spatially distributed antennas is shown. Simulation results are provided to prove the validity of the proposed approach, which proves that adding a localization feature to the system layer is feasible with an acceptable error range that does not exceed 1.1%.
INTELLIGENT ENVIRONMENTAL SENSING WITH AN UNMANNED AERIAL SYSTEM IN A WIRELESS SENSOR NETWORK
Authors: Chen Ching-Ju , Chen Jou-An , Huang Yueh-Min 
Published: November 2017

Abstract
This paper proposes a novel environmental monitoring mechanism to integrate recently- established development of an Unmanned Aerial System (UAS) with WSNs for remote monitoring. The high mobility of UASs can solve the limitations associated with using WSNs in hazardous areas. In this paper, the WSN node, the Wireless Environmental Monitoring Station (WEMS), is based on ZigBee protocol for long-duration monitoring. Furthermore, to ensure the integrity of collected environmental data, an algorithm is designed in WEMS for verification. Finally, a detailed analysis of packet transmission efficiency based on ranges of flight distance is proposed to examine the effect of environmental monitoring.
Efficient Approaches for Designing the Logical Reversibility of Computation
Authors: Anto Bennet M , Mari Selvi T. , Mohana Priya S. , Monica S , Kanimozhi R. 
Published: November 2017

Abstract
The work demonstrates about the reversible logic synthesis for the 2 to 4 decoder, the circuits are designed using reversible fault tolerant toffoli gates. Thus the entire scheme inherently becomes fault tolerant. In addition, several lower bounds on the number of constant inputs, garbage outputs and quantum cost of the reversible fault tolerant decoder have been proposed. Transistor simulations of the proposed decoder power consumption have been reduced than the existing approach without decreasing the speed, which proved the functional correctness of the proposed Decoder. The comparative results show that the proposed design is much better in terms of quantum cost, delay, hardware complexity and has significantly better scalability. Tanner software is the advanced industrial tool that is growing up in trend. So the proposed decoder is designed in Tanner EDA after completion of the circuit in DSCH and Microwind. This shows the power dissipation and power consumption at each nook and corner to re-design with low power consumption possible.
Android Based Home Automation and Energy Conservation
Authors: Anto Bennet M. , Thamilvalluvan B. , Hema Priya C.A. , Bhavani B. , Shalini M. 
Published: November 2017

Abstract
Wireless Sensor Network (WSN) consists of three main components: nodes, gateways, and software. The spatially distributed measurement nodes interface with sensors to monitor assets or their environment. In a WSN network the devices are connected to WSN nodes wherein the entire nodes uses Zigbee network to transfer the status of connected applications to a controller which controls the whole applications but the main drawback of Wireless sensor networks is its high interference, low coverage area and ability to control only low power devices. In order to overcome these drawbacks Android equipped devices are used to control the applications over GPRS network. Android equipped devices allow the user to control various applications over wireless networks. Being an open sourced platform it allows the user to design a custom module which controls the home applications by connecting the android equipped device and its corresponding home applications to an MCU wherein it uses relay circuits to connect the entire applications using GPRS network to connect the application controller and the android device. These devices can be used to control industrial applications, home applications like light, fan etc., and thereby conserving electricity.
Instance Vehicle Monitoring and Tracking with Internet of Things Using Arduino
Authors: Dhanalakshmi  , Ezil Sam Leni A. 
Published: November 2017

Abstract
The Vehicle Tracking System has the capability of finding the Vehicle location, Gas Leakages, Vehicle Speed, and Vehicle Accident and at the same time notifies the owners of the vehicle through a GSM network with an SMS alert message. The drivers require their presence to their family or to their respective one’s. The main aim is to design a low cost and an efficient vehicle tracking and vehicle security circuit based on an Arduino microcontroller. This system can be made as a backup sector inside the vehicles to prevent them from stolen and easy to identify the location and prevent from other disaster factors. The main methodology of the device is to monitoring the vehicle speed via Ethernet shield through Internet of things. The protective system is maintained by analysing gas tank through gas sensor which details about the gas leakage. The advantages of this device are alarming the driver when there is any gas leakage in the vehicle and also informs about the speed of the car. A vibrating sensor is used to alert when the vehicle is struck with some accident by sending SMS to the required people via GSM Modem and all the data which can be viewed by the driver can be viewed by the people in home via Ethernet device.
Hybrid Power Harvester Using Engine Source
Authors: Ahmed Meeran Mydeen A. , Inasu Kelwin , Venkatesh M. , Suthesh C. 
Published: November 2017

Abstract
In mainly we present a compact, multisource and battery-free energy harvesting from engine source. This battery free generator captures energy from its environment transient thermal gradients as a main source, and vibration as a secondary source allowing early biasing of the generator and stores this energy in ultracapacitors .In this way, this multi-source architecture benefits from the synergy between energy scavenging and harvesting.
Hardware Implementation of Uwb Radar for Detection of Trapped Victims in Complex Environment
Authors: Anto Bennet M. , Narmatha J. , Pavithra B. , Suvetha P. , Sandhyalakshmi A. 
Published: November 2017

Abstract
Ultra-wideband (UWB) radar plays an important role in search and rescue at disaster relief sites. Identifying vital signs and locating buried survivors are two important research contents in this field. In general, it is hard to identify a human’s vital signs (breathing, body temperature, brain waves and heartbeat) in complex environments due to the low signal-to-noise ratio of the vital sign in radar signals. In this paper, advanced signal-processing approaches are used to identify and to extract human vital signs in complex environments. First, we apply Curvelet transform to remove the source–receiver direct coupling wave and background clutters. Next, singular value decomposition is used to de-noise in the life signals. Finally, the results are presented based on FFT and Hilbert-Huang transform to separate and to extract human vital sign frequencies, as well as the micro-Doppler shift characteristics. The proposed processing approach is first tested by a set of synthetic data generated by FDTD simulation for UWB radar detection of two trapped victims under debris at an earthquake site of collapsed buildings.
Design of Low Power Carry Skip Adder Using Dtcmos
Authors: Dinesh Kumar T.R. , Mohana Sundaram K. , Anto Bennet M. , Aruna R. , Meena B. , Mohanapriya M. 
Published: November 2017

Abstract
In the domain of VLSI design, the adders are always meant to be the most fundamental requirements for processors of high performance and other multicore devices. It is found that power dissipation is a major problem in the electronic devices. Power management integrated circuit (PMIC) is emphasized as battery-powered portable electronics such as smart phone are commonly used. In this paper we are designing a carry skip adder which consumes less power than the other conventional adders using dynamic threshold complementary metal oxide semiconductor (DTCMOS).Tthe circuit is designed using tanner EDA simulator of 32nm technology. Also the circuit is compared with the CMOS technology methods.
Design of Sram Architecture with Low Power without Affecting Speed Using Finfet
Authors: Mohammed Sulaiman S. , Jaison B. , Anto Bennet M. , Vijay M. , Pandi Selvam V. , Anandakumar P. 
Published: November 2017

Abstract
In average 8T SRAM Architecture, it requires maximum number of transistor counts and does not need any write back scheme. To achieve the higher word line (WL) Voltage, the bit line (BL) is connected to the gate of the read buffer SRAM Architecture. That boosted voltage is not used when the threshold voltage is high. Its leads to the reduction of read stability of the SRAM Design. In that case, the gate terminal of the SRAM Architecture is not connected to the buffer results a large delay. To overcome the disadvantage of the average 8T SRAM architecture, the 6T SRAM Design is proposed. In proposed 6T SRAM Design, the number of transistor counts and Power is reduced than the existing design. Various factors of the proposed SRAM Architecture, which stores multiple bits in terms of power and transistor counts. The simulation of 6T SRAM design is carried out in S-Edit and the synthesized in T-Spice.