bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gendered administrative burden: regulating gendered bodies, labor, and identity
Authors: Herd Pamela , Moynihan Donald 
Published: October 2024

Abstract
Gendered burdens are experiences of coercive and controlling state actions that directly regulate gendered bodies, labor, and identity. Burdens are not simply about preventing access to rights and benefits, they're about control and coercian. Gendered burdens generate gender inequality through four mechanisms. First, administrative burdens regulate reproductive bodies, legitimating the state’s direct control over reproductive health care, including abortions, with consequent implications for peoples’ health. Second, burdens require reproductive labor, shifting unpaid and underpaid reproductive labor onto women as the policies that support such labor tend to have high administrative burdens that impede access. Third, gendered burdens restrict reproductive labor, impeding the right to provide such care labor with dignity, by exerting control over how, and sometimes whether, care is performed, including in rights-granting venues, like redistributive benefits, and rights-depriving venues, like the supervision of families by child protective services. Fourth, burdens regulate gendered identities, reinforcing heteronormative and cis-normative constructions of gender, including by directly controlling gender identification. While gendered burdens are not only experienced by women, they are most strongly applied to poor and racially marginalized groups of women. These claims provide a basis for public administration scholarship to connect with feminist theory by illustrating the centrality of administrative processes and related experiences to structural patterns of inequality.
What interval of daily pain assessment is required to reliably diagnose chronic pain in SCD? The Pain in Sickle Cell Epidemiology Study
Authors: Smith Wally Renee , McClish Donna K , Valrie Cecelia , Sisler India 
Published: October 2024

Abstract

Objectives
Chronic pain in SCD has been defined as pain on most days over 6 months. In the landmark Pain in Sickle Cell Epidemiology Study, 60% of patients submitted &lt;5 of the expected 6 months of pain diaries. Identifying chronic SCD pain using this long daily assessment interval is impractical. We therefore examined whether shorter, less burdensome intervals could accurately identify chronic SCD pain.

Methods
As the gold-standard sample, we chose the 116 Pain in Sickle Cell Epidemiology Study patients who submitted &gt;5 months of diaries (153) and &gt;49% of diaries during all months from 1 to 4. Using the same dataset, we tested daily diary assessment over shorter intervals: 2 weeks, 1 month, 2 months, 3 months, and 4 months. We defined chronic pain as intensity rated as &gt;0 on &gt;50% of diary days, regardless of interval. We then calculated the sensitivity and specificity of each diary interval.

Results
Among the gold-standard sample, 51.3% of patients had diary-defined chronic pain. Collection intervals of 2 months or more yielded similar chronic pain prevalences with identically high sensitivity (98.3%) and specificity (93%). Intervals of 1 month and 2 weeks yielded increasingly lower specificity (80.7%, 73.7%, respectively), but preserved sensitivity (≥96.6%).

Conclusion
In the Pain in Sickle Cell Epidemiology Study, intervals of 2 months or more of daily diary collection yielded high sensitivity and specificity, compared to an interval of 5-6 months. One may reasonably diagnose chronic SCD pain using 2 months of daily diaries.
Marine Pseudomonas: diving into the waves of blue biotechnology
Authors: Canellas Anna Luiza Bauer , Laport Marinella Silva 
Published: October 2024

Abstract
From marine to terrestrial environments, Pseudomonas spp. exhibit a remarkable ability not only to adapt but also thrive even amidst adverse conditions. This fact turns Pseudomonas spp. into one of the most prominent candidates for novel biotechnological solutions. Even though terrestrial isolates have been extensively studied, there is still an almost untapped source to be explored in marine Pseudomonas. Harnessing such strains offers an opportunity to discover novel bioactive compounds that could address current global challenges in healthcare and sustainable development. Therefore, this minireview aimed to provide an overview of the main recent discoveries regarding antimicrobials, antifouling, enzymes, pigments, and bioremediation strategies derived from marine isolates of Pseudomonas spp. Future research perspectives will also be discussed to foster forthcoming endeavors to explore the marine counterparts of such a prolific bacterial genus.
Rotational excitation of methyl mercaptan (CH3SH) in collisions with molecular hydrogen
Authors: Dagdigian Paul J 
Published: October 2024

ABSTRACT
This paper presents the calculation of rate coefficients for transitions between rotational levels of the A-type and E-type levels of methyl mercaptan (CH$_3$SH), resulting from collisions with molecular hydrogen. Radiative transfer modelling requires both radiative and collisional rates to describe the rotational populations under the usual conditions in interstellar clouds where local thermodynamic equilibrium conditions do not apply. To compute the intermolecular interaction between CH$_3$SH and H$_2$, the explicitly correlated CCSD(T)-F12a coupled-cluster method that utilized a correlation-consistent aug-cc-pVTZ basis was employed. The computed energies were fit to a functional form suitable for use in scattering calculations. Rate coefficients were calculated over the temperature range from 5 to 100 K for transitions between the 110 lowest CH$_3$SH rotational levels (having energies less than 107 cm$^{-1}$ (ca. 150 K) within both the A-type and E-type manifolds caused by collisions with para- and ortho-H$_2$. The rate coefficients were obtained through time-independent quantum close coupling quantum scattering calculations utilizing the calculated potential energy surface.
High precision accelerator for our hybrid model of the redshift space power spectrum
Authors: Icaza-Lizaola M , Song Yong-Seon , Oh Minji , Zheng Yi 
Published: October 2024

ABSTRACT
Upcoming Large Scale Structure surveys aim to achieve an unprecedented level of precision in measuring galaxy clustering. However, accurately modelling these statistics may require theoretical templates that go beyond two-loop order perturbation theory, especially for achieving precision at smaller scales. In our previous work, we introduced a hybrid model for the redshift space power spectrum of galaxies. This model combines two-loop order templates with N-body simulations to capture the influence of scale-independent parameters on the galaxy power spectrum. However, the impact of scale-dependent parameters was addressed by pre-computing a set of input statistics derived from computationally expensive N-body simulations. As a result, exploring the scale-dependent parameter space was not feasible in this approach. To address this challenge, we present an accelerated methodology that utilizes Gaussian Processes, a machine-learning technique, to emulate these input statistics. Our emulators exhibit remarkable accuracy, achieving reliable results with just 13 N-body simulations for training. Our emulators can reproduce the set of statistics we are interested in with less than 0.1 per cent error in the parameter space within $5\sigma$ of the Planck Lambda cold dark matter predictions, specifically for scales around $k \gt 0.1$ h Mpc$^{-1}$. Following the training of our emulators, we can predict all inputs for our hybrid model in approximately 0.2 s at a specified redshift. Given that performing 13 N-body simulations is a manageable task, our present methodology enables us to construct efficient and highly accurate models of the galaxy power spectra within a manageable time frame.
Multiwavelength high-resolution polarimetric imaging of second-generation disc around post-AGB binary IRAS 08544–4431 with SPHERE
Authors: Andrych Kateryna , Kamath Devika , Van Winckel Hans , Kluska Jacques , Schmid Hans Martin , Corporaal Akke , Milli Julien 
Published: October 2024

ABSTRACT
Exploring the formation and evolution of second-generation circumbinary discs around evolved binary stars, such as post-asymptotic giant branch (post-AGB) and post-red giant branch binaries, provides valuable insights into the complex binary interaction process that concludes the red-giant phase of evolution in these systems. Additionally, it offers a novel opportunity to investigate the formation of second-generation planets within dusty discs surrounding evolved stars. We present a pilot multiwavelength polarimetric imaging study of the post-AGB binary system IRAS 08544–4431 using the European Southern Observatory–Very Large Telescope/Spectro-Polarimetric High-contrast Exoplanet Research (VLT/SPHERE) instrument. This study is focused on optical V- and $I^{\prime }$-band Zurich Imaging Polarimeter (ZIMPOL) data to complement near-infrared (near-IR) H-band IRDIS data presented previously. The study aims to investigate the dust scattering properties and surface morphology of the post-AGB circumbinary disc as a function of wavelength. We successfully resolved the extended disc structure of IRAS 08544–4431, revealing a complex disc morphology, high polarimetric disc brightness (up to $\sim$1.5 %), and significant forward scattering at optical wavelengths. Additionally, we found that the disc shows a grey polarimetric colour in both optical and near-IR. The findings highlight similarities between post-AGB circumbinary discs and protoplanetary discs, suggesting submicron-sized porous aggregates as the dominant surface dust composition, and indicating potential warping within the disc. However, further expansion of the multiwavelength analysis to a larger sample of post-AGB binary systems, as well as high-resolution observations of dust continuum and gas emission, is necessary to fully explore the underlying structure of post-AGB circumbinary discs and associated physical mechanisms.
Graphite: painting genomes using a colored de Bruijn graph
Authors: Beeloo Rick , Zomer Aldert L , Deorowicz Sebastian , Dutilh Bas E 
Published: October 2024

Abstract
The recent growth of microbial sequence data allows comparisons at unprecedented scales, enabling the tracking of strains, mobile genetic elements, or genes. Querying a genome against a large reference database can easily yield thousands of matches that are tedious to interpret and pose computational challenges. We developed Graphite that uses a colored de Bruijn graph (cDBG) to paint query genomes, selecting the local best matches along the full query length. By focusing on the best genomic match of each query region, Graphite reduces the number of matches while providing the most promising leads for sequence tracking or genomic forensics. When applied to hundreds of Campylobacter genomes we found extensive gene sharing, including a previously undetected C. coli plasmid that matched a C. jejuni chromosome. Together, genome painting using cDBGs as enabled by Graphite, can reveal new biological phenomena by mitigating computational hurdles.
More than words: can free reports adequately measure the richness of perception?
Authors: Hirschhorn Rony , Mudrik Liad 
Published: October 2024

Abstract
The question of the richness (or sparseness) of conscious experience has evoked ongoing debate and discussion. Claims for both richness and sparseness are supported by empirical data, yet they are often indirect, and alternative explanations have been put forward. Recently, it has been suggested that current experimental methods limit participants’ responses, thereby preventing researchers from assessing the actual richness of perception. Instead, free verbal reports were presented as a possible way to overcome this limitation. As part of this approach, a novel paradigm of freely reported words was developed using a new metric, intersubjective agreement (IA), with experimental results interpreted as capturing aspects of conscious perception. Here, we challenge the validity of freely reported words as a tool for studying the richness of conscious experience. We base our claims on two studies (each composed of three experiments), where we manipulated the richness of percepts and tested whether IA changed accordingly. Five additional control experiments were conducted to validate the experimental logic and examine alternative explanations. Our results suggest otherwise, presenting four challenges to the free verbal report paradigm: first, impoverished stimuli did not evoke lower IA scores. Second, the IA score was correlated with word frequency in English. Third, the original positive relationship between IA scores and rated confidence was not found in any of the six experiments. Fourth, a high rate of nonexisting words was found, some of which described items that matched the gist of the scene but did not appear in the image. We conclude that a metric based on freely reported words might be better explained by vocabulary conventions and gist-based reports than by capturing the richness of perception.
Radiological, clinical, and molecular analyses reveal distinct subtypes of butterfly glioblastomas affecting the prognosis
Authors: Shibahara Ichiyo , Shigeeda Ryota , Watanabe Takashi , Orihashi Yasushi , Tanihata Yoko , Fujitani Kazuko , Handa Hajime , Hyakutake Yuri , Toyoda Mariko , Inukai Madoka , Uemasu Kohei , Shinoda Mitsuhiro , Komai Hideto , Sato Sumito , Hide Takuichiro , Kumabe Toshihiro 
Published: October 2024

Abstract

Background
Glioblastoma (GB) is known for its highly invasive nature. Images of butterfly GB (bGB) often illustrate this characteristic, but the molecular background and origins of bGB remain unknown.

Methods
We analyzed a cohort of 34 bGB patients from our dataset (K-cohort) and 46 bGB patients from publicly available datasets, including TCGA-GBM, CPTAC-GBM, IvyGAP, and UPENN-GBM.

Results
In the K-cohort, the median age was 66 years, and molecular analyses revealed TERT promoter mutations in 55.9% of cases, with no cases exhibiting H3F3A, HIST1H3B, or BRAF mutations. Sequential radiological imaging from the K-cohort provided unique insights, showing one case originating in the corpus callosum (CC) and 3 cases originating in the cerebral hemisphere before developing into bGB. Multi-regional sampling supported a mutational trajectory from the hemisphere to the CC. These observations indicate the presence of 2 distinct radiological origins for bGB. Consequently, we classified cases into CC-type and Hemispheric-type based on the tumor volume ratio within the CC. This subgrouping was clinically meaningful; the CC-type is an independent poor prognostic factor for overall survival, with a hazard ratio of 1.8 (95% confidence interval 1.1–3.0, P = .033), and is molecularly distinct by a higher frequency of methylated MGMTp (P = .0039) compared to the Hemispheric-type.

Conclusions
Our results highlight that the radiological features of bGB are not homogenous and can indicate 2 potential subtypes based on their origins. Further studies are mandatory, but CC-type and Hemispheric-type exhibit distinct clinical backgrounds, outcomes, and molecular features.
Factors contributing to variability in neurocognitive performance before glioma neurosurgery
Authors: Lövgren Izabelle , Voets Natalie Laura , Isaac Claire , Honeyman Susan Isabel , Mier Juan Felipe , Stacey Richard , Apostolopoulos Vasileios , Plaha Puneet 
Published: October 2024

Abstract

Background
Cognitive impairment following anti-tumor treatment is a common concern for brain tumor patients. However, growing evidence indicates that significant impairments can be present even before treatment. The purpose of this study was to identify factors that explain variability in pretreatment test performance, beyond that of tumor burden.

Methods
Using multi-step linear regression, we retrospectively probed the contribution of clinical-, tumor-, patient-, and self-reported factors to variance in performance among 96 treatment-naïve brain tumor patients across 13 objective neurocognitive tests. Agreement between subjective and objective reports of cognitive impairment was also examined.

Results
Clinically significant preoperative impairments were observed in both objective and subjective domains. Estimated premorbid intelligence quotient (IQ), tumor volume, diagnosis of an astrocytoma, self-reported depression, and perceived cognitive functioning scores were the most common predictors of objective neurocognitive performance prior to treatment, explaining 12.3%–58.3% of the variance. No association was identified between objective and subjective reports of cognitive impairment.

Conclusions
Glioma patients frequently exhibit objective and subjective impairments prior to treatment. Both tumor- and self-reported factors were identified as predictors of performance, after correcting for estimated premorbid IQ. Nevertheless, more than 41.7% of the variance in cognitive performance remained unexplained, indicating a substantial role for additional, as yet unaccounted for, clinical factors. Notable disparity between objective and subjective cognitive impairment status re-emphasizes the importance of assessing both domains to ascertain a patient’s overall functioning in the context of treatment outcomes.
Tropical Indian Ocean drives Hadley circulation change in a warming climate
Authors: Sun Yong , Ramstein Gilles , Fedorov Alexey V , Ding Lin , Liu Bo 
Published: October 2024

ABSTRACT
The weakening and poleward expansion of the Hadley circulation (HC) are considered robust responses of atmospheric meridional circulation to anthropogenic warming. Climate impacts arising from these changes enhance drought conditions and reduce food production in the affected regions. Therefore, understanding the mechanisms of HC changes is critical to anticipating the resultant climate risks. First, we demonstrate that robust future HC changes in boreal winter, and the uncertainty in their future projections, are both largely related to sea surface temperature (SST) warming. Next, we investigate the impact of anthropogenic regional ocean warming on the future HC. Accordingly, we conduct a large ensemble of individual ocean basin perturbation experiments at 1.5°C, 2°C, and 3°C warming thresholds (as in the Paris Agreement). These experiments highlight (i) the leading role of tropical Indian Ocean warming in HC changes and (ii) inter-model differences in tropical Pacific warming as a source of uncertainty in HC projections.
Implementation of Injectable Cabotegravir/Rilpivirine for Treatment of Human Immunodeficiency Virus in Patients With Substance Use Disorders at a Syringe Exchange Clinic
Authors: Perez Amanda , Nieves Shane , Meisner Jessica 
Published: October 2024

Abstract
Cabotegravir + rilpivirine (CAB + RPV-LA) is a long-acting antiretroviral therapy (ART) that can be utilized for people with human immunodeficiency virus (HIV) who face barriers to daily ART. Here, we describe the implementation of a program that provides low-barrier access to CAB + RPV-LA for people with HIV and opioid use disorder at a syringe exchange.
02 Youth perspectives on virtual healthcare appointments in Nova Scotia – a qualitative study
Authors: Bartlett Emma , Wong Tania , Mokashi Arati , Poole Emily 
Published: October 2024

Abstract

Background
With the onset of the COVID-19 pandemic, public safety measures required healthcare providers to look for alternative ways of delivering care in a safe and timely fashion. This led to an escalated use of virtual appointments to continue to provide patient care. For future decision-making regarding virtual care in our community, we must consider the youth perspective to ensure our healthcare delivery meets the needs of this patient population.

Objectives
Our study aims to determine the perspectives of local youth patients on their experience with virtual and in-person paediatric clinic appointments.

Design/Methods
Participants were recruited from general and subspecialty paediatrics clinics at the IWK Health Centre, in Nova Scotia, Canada. Eligibility criteria included attending both a virtual and in-person appointment from 2019-2022. Participants completed a semi-structured interview and provided their perspective on comfort level, accessibility, participation, and general preferences between virtual and in-person clinics. Transcribed data was analyzed using thematic analysis with both inductive and deductive approaches to identify themes.

Results
12 participants aged 14-18 provided interviews. Participants represented clinical areas of general paediatrics, rheumatology, diabetes clinic and gender clinic. Virtual appointments were preferred for convenience, flexibility, and efficiency during shorter conversations. In-person appointments were preferred for physical concerns, communication and relationship building. Some youth appreciated talking face-to-face for the ease of communication, feeling able to “get the point across” in this setting. The value of the in-person connection with their healthcare team was expressed by some youth, and building this relationship held importance. When appointments provided education, youth preferred for that information to be delivered in-person. Participants overall felt more comfortable during virtual appointments, and participation levels varied based on the individual and not based on an appointment being virtual versus in-person. Accessibility issues were predominantly associated with in-person appointments, with barriers including access to transportation, time spent attending appointment, and the cost of travelling to a tertiary care centre.

Conclusion
Youth patients have unique and individual preferences for virtual versus in-person appointments. This study provided insight into situations when each appointment type should be considered and emphasizes the importance of including the youth in the decision-making process around appointment scheduling when possible.