bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing a Resilience Training Program in Police Recruits: A Pilot Study
Authors: Ramey Sandra L. , Perkhounkova Yelena , Hein Maria , Bohr Nicole L. , Anderson Amanda A. 
Published: March 2017

Background: Stress from multiple sources is inherent in law enforcement. However, it is possible to modify responses to stress with resilience training that includes teaching techniques to modify emotional and physical responses to stress, interface with mental health professionals, and practice sessions to improve self-regulation of responses to stress including coherence, a measure of heart rate variability. A gap exists in the research, however, regarding evaluation of the duration of effects after the initial resilience training. Method: Subjects included ( N = 34) recruits enrolled in summer 2015 at the Milwaukee Police Academy. An experimental design was used to compare recruits who received resilience training to recruits in the control group. Results: No statistically significant differences between the groups were found for self-reported measures of stress and resilience. For the treatment group ( n = 17), change in coherence was significant ( p < .001) and improvement in the Personal Organizational Quality Assessment Emotional Buoyancy subscale correlated significantly with the number of practice sessions ( r = .63, p = .01) and marginally with change in coherence ( r = .47, p = .07). Conclusion: Results confirm several significant effects of resilience training with recruits.
Hip Capsular Closure
Authors: Chahla Jorge , Mikula Jacob D. , Schon Jason M. , Dean Chase S. , Dahl Kimi , Menge Travis James , Turnbull Travis L. , Soares Eduardo , LaPrade Robert F. , Philippon Marc J. 
Published: March 2017

Objectives: Iatrogenic instability can result after hip arthroscopy due to capsular insufficiency, which can be avoided with an effective closure of the hip capsule. There is currently no consensus in the literature regarding the optimal quantity of sutures upon capsular closure to achieve maximal stability postoperatively. The objective of this study was to determine the strength of one-, two-, and three-suture constructs for hip capsular closure to resist external rotation and extension following a standard anterosuperior inter-portal capsulotomy (12 to 3 o’clock). Additionally, the degree of external rotation at which the suture constructs failed was recorded. Methods: Nine pairs ( n = 18) of fresh-frozen human cadaveric hemi-pelvises underwent anterosuperior inter-portal capsulotomies, which were repaired with one, two, or three side-to-side sutures. Each hip was secured in a dynamic, biaxial testing machine and underwent a cyclic external rotation preconditioning protocol followed by external rotation to failure ( Figure 1 ). The non-parametric version of the BIBD ANOVA analysis (Durbin test) was used to assess the primary hypothesis that different suture numbers are associated with different torque capacities. When the omnibus Durbin test was statistically significant, post-hoc comparisons were made using Conover’s method, and the Holm-Bonferroni method was used to control the type-1 error. Group medians and ranges were reported. Significance was set at p < 0.05. [Figure: see text] Results: The failure torque of a one-suture hip capsular closure construct was significantly less than the three-suture construct. The failure torque for the one-suture construct was 67.4 N-m (range: 47.4 - 73.6 N-m). For two sutures, the failure torque was 85.7 N-m (range: 56.9 - 99.1 N-m) and for three sutures the failure torque was 91.7 N-m (range: 74.7 - 99.0 N-m). Repair constructs exhibited 36º (range: 22° - 64°) of external rotation at failure torque. Conclusion: The most important finding of this study was that three sutures provided the strongest biomechanical construct, demonstrating a median maximum torque of nearly 91.7 N-m. A three-suture construct was significantly stronger than one suture; however, there was not a significant difference between two- and three-suture constructs. Additionally, constructs failed at approximately 35° of external rotation, providing an important guideline for appropriate rehabilitation to protect the capsular repair in the early postoperative period. Reestablishing the native anatomy of the hip capsule following hip arthroscopy has been reported to result in improved outcomes and reduce the risk of iatrogenic instability. Therefore, an adequate capsular closure is important to restore proper hip biomechanics, and postoperative precautions limiting external rotation should be utilized to protect the repair. [Figure: see text]
Incidence and Return to Play after Biceps Tenodesis in Major League Baseball Players
Authors: Chalmers Peter Nissen , Erickson Brandon J. , Verma Nikhil N. , Romeo Anthony A. 
Published: March 2017

Objectives: Superior labral anterior-posterior (SLAP) tears are a common source of inability to play among baseball players of all levels. SLAP repair is unpredictable and thus biceps tenodesis (BT) has been proposed as an alternative. Furthermore, tenodesis may be indicated for pain isolated to the biceps tendon. The incidence of BT among professional baseball players is unknown, as are the rates of return to play (RTP). The purpose of this study was to determine RTP rates after BT among professional baseball players. Methods: Major League Baseball (MLB) has maintained a prospective database containing all major and minor league baseball players who have undergone shoulder surgery since 2010. Using this database we determined the incidence, demographics, position, prior surgical history, concomitant procedures, RTP rates, time to RTP, and performance upon RTP for professional baseball players following BT. Minimum follow-up was 2 years. Results: Between 2010 and 2013, 17 professional baseball players underwent BT, of which 71% were pitchers, and 29% were in the major league. Forty-seven percent had a history of prior shoulder surgery and 47% underwent concomitant labral repair. Overall RTP after BT was 35%. RTP for isolated BT was 44% in 0.8±0.5 years while RTP for those who underwent both BT and labral repair was 25% (p=0.620). All players who RTP were able to return to at least ten games at their pre-operative level of play. Return to professional play was significantly more common among position players than pitchers (80% vs. 17%, p=0.028). RTP was less common among players with prior shoulder surgery, but this was not statistically significant (56% vs. 13%, p=0.131). For those players who did RTP, pre-operative and post-operative performance was unchanged. Conclusion: Professional baseball players who undergo biceps tenodesis have a 35% rate of return to their prior level of play. While pitchers have only a 16% rate of return to play, position players have an 80% rate of return to play. Furthermore, 100% of those who returned to baseball played at least 10 games at their pre-operative level with no significant change in performance statistics. Professional baseball players who choose to undergo biceps tenodesis should be counseled regarding the low rates or return to play. Pitchers in particular may have a poor prognosis following tenodesis. However, given the small sample size and concomitant procedures, further study is needed before definitive conclusions can be made.
Determining the Patient Acceptable Symptomatic State for Patients Undergoing Arthroscopic Partial Meniscectomy in the Knee
Authors: Zochowski Thomas , Dwyer Tim , Ogilvie-Harris Darrell , Theodoropoulos John S. , Whelan Daniel B. , Murnaghan Michael Lucas , Wasserstein David , Gillis Jennie , Chahal Jaskarndip 
Published: March 2017

Objectives: Arthroscopic partial meniscectomy is one of the most commonly performed procedures in orthopaedic surgery. However, information on the threshold at which patients consider themselves to be well for patient reported outcome measures (PROMs) after this surgery remains limited. Our goal was to determine the patient acceptable symptomatic state (PASS) for the Knee Injury and Osteoarthritic Outcome Score (KOOS), the International Knee Documentation Committee (IKDC) Subjective Knee Form, the Western Ontario Meniscal Evaluation Tool (WOMET) and the Marx Activity Scale (MAS) in patients with knee meniscal pathology who treated with partial knee meniscectomy. Methods: A consecutive series of patients with knee meniscal pathology treated with arthroscopic partial meniscectomy plus or minus intra-articular debridement were eligible. Other inclusion criteria were: a Kellegren-Lawrence Grade of 0-2, and ligamentous integrity. The KOOS (0-100, 5 subscales), IKDC (0-100), WOMET (0-100) and MAS (0-16) were administered at baseline and 12 months postoperatively. An external anchor question at 1 year postoperatively was utilized to determine PASS values: “Taking into account all the activities you have during your daily life, your level of pain, and also your functional impairment, do you consider that your current state is satisfactory?” A receiver operator curve analysis was used to determine the PASS value at which patients considered their status to be satisfactory. Results: There were 115 patients (mean ± SD age, 53.8 ± 12.0 years), and 57.3% were male. Based on a receiver operator curve analysis, the PASS values - at which patients considered their status to be satisfactory - at 1 year after surgery were 43 (KOOS-symptoms subscale), 83 (KOOS-pain subscale), 84 (KOOS-functions of daily living subscale), 75 (KOOS-function, sport and recreational activity subscale), 56 (KOOS-quality of life subscale), 56 (IKDC), 61 (WOMET), 7 (MAS). The PASS threshold was not affected by baseline scores across the different instruments and there was no relationship between baseline score and likelihood of achieving the PASS. Age and sex were not significantly related to the odds of achieving the PASS for any of the PROMs. Conclusion: This is the first study to determine PASS in four commonly used knee-related PROMs in patients undergoing arthroscopic partial meniscectomy. The findings can allow researchers and clinicians to determine if partial meniscectomy is meaningful to patients and will be helpful for responder analysis in future trials related to knee arthroscopy and the treatment of meniscal pathology.
Chondral Defect Repair with Particulated Juvenile Cartilage Allograft
Authors: Belkin Nicole , Burge Alissa , Chang Brenda , Williams Riley J. 
Published: March 2017

Objectives: To evaluate the functional outcomes and morphologic appearance of repair tissue in patients with symptomatic knee articular cartilage defects treated with minced juvenile articular cartilage (DeNovo NT). Methods: Thirty-four patients underwent treatment of cartilage defects of the knee with minced juvenile articular cartilage allograft. Mean postoperative follow up was 33.6 months. MRIs were obtained at 24-months (16 patients) and 48-months or greater (13 patients). MRIs were evaluated for greyscale cartilage repair assessment score and quantitative T2 mapping. Baseline clinical outcome scores (IKDC, ADL, Marx Activity Rating Scale) were obtained prior to surgery, and at a minimum follow up interval of 24-months. Results: The mean IKDC and ADL scores significantly improved following surgery. The magnitude of improvement in IKDC scores was 30 (Std Dev 31). The Marx activity Rating Scale score demonstrated a resumption of pre-operative activity levels, Figure 1a . Donor age had no significant effect on functional outcomes scores of treated patients. MRI assessment revealed greater than 66% lesion fill (a score of 2) in 80% of patients. A trend toward significance in difference in % lesion fill was observed when patients were grouped according to donor age ≤ 5 vs. > 5 years (p = 0.09), Figure 1b . Lesion fill did not correlate with functional outcome score. Using one-way analysis of variance with post-hoc testing, a significant difference was found between T2 mapping of the deep zones of the graft and normal cartilage (p=0.003), Table 1 . [Figure: see text][Table: see text] Conclusion: Functional outcome scores significantly improved in patients treated with minced juvenile articular cartilage (De Novo NT) for the treatment of symptomatic articular cartilage lesions of the knee. Activity levels, as noted by the Marx Activity Scale were preserved. Morphologic analysis demonstrated greater than 66% lesion fill in 80% of the patients studied. T2 mapping demonstrated the sensitivity to assess differences between repair tissue and native cartilage.
Introduction of a Surgical Navigator in the Perioperative Process Improves Patient Satisfaction
Authors: Marshall Brett G , Assef Maija S , Pitney Ryan B , Macco Maria CJ , Tschoeke Bradley M , Oksa Marcus A , Yeatman Amy 
Published: March 2017

Background: Patients who had received surgical services at Bellin Hospital reported anxiety with the surgical flow. This study tested the hypothesis that the introduction of a surgical navigator, someone who guided the patient and their accompanying others throughout the surgical process, would improve patient satisfaction. Methods: Ambulatory surgical patients were randomized to control and study groups. The study group patients were assigned a surgical navigator. Prior to discharge from the hospital, patients were asked to complete a patient satisfaction survey. Results: The study group had significantly higher mean scores ( P value ≤ 0.026), top box scores ( P value ≤ 0.021), and positive comments. Conclusion: The addition of a surgical navigator to the perioperative process significantly enhanced patient satisfaction in ambulatory surgical patients.
The Synthesis of Size-Adjustable Superparamagnetism Fe3O4 Hollow Microspheres
Authors: Xu Chao , Lu Xiaolong , Dai Honglian 
Published: March 2017

AbstractOne hundred fifty to 300-nm-sized monodisperse iron oxide (Fe3O4) hollow microspheres were synthesized by the one-pot hydrothermal method. The morphology and crystal structure of the as-prepared hollow microspheres was characterized by scanning electron microscopy, X-ray diffraction, transmission electron microscopy, and high-resolution transmission electron microscopy, while the magnetic property was investigated by vibrating sample magnetometer. We found that the particle size of the hollow microspheres was related to the amount of sodium citrate, polyacrylamide (PAM), and urea. The hollow structure of Fe3O4 microspheres has high magnetization saturation values ranging in 49.10–75.41 emu/g.
Health-related quality of life outcomes in a phase I/II study of stereotactic hypofractionated once-weekly radiation therapy (SHORT) for nonmetastatic prostate cancer.
Authors: Mallick Indranil , Arunsingh Moses , Gupta Sujoy , Mukherjee Satyadip , Chatterjee Sanjoy , Shrimali Raj K , Achari Rimpa 
Published: March 2017

126 Background: Stereotactic Radiation Therapy (SRT) for prostate cancer offers an opportunity to exploit the low alpha/beta ratio of prostate cancer. We present patient reported health-related Quality-of-life (HR-QoL) outcomes of an SRT schedule with once-weekly fractionation in an unselected cohort of non-metastatic prostate cancer. Methods: In a Phase I/II study 30 patients with non-metastatic prostate cancer (multiparametric MRI cT1-4N0, M0, Gleason 6-10, PSA < = 60 ng/ml) were treated to a dose of 35Gy in 5 fractions delivered once a week (along with simultaneous elective nodal radiotherapy at 25Gy/5Fr to patients high-risk by NCCN criteria). Androgen deprivation therapy given to intermediate and high-risk patients. Treatments were planned using volumetric intensity modulated arc therapy. Quality of life was assessed using the EORTC QLQ C30 and PR25 questionnaires. HR-QoL parameters at baseline (before start of SRT) was compared to those at treatment completion and 3 months post-SRT. The raw QoL scores were converted to a scale of 0-100 by convention. A scale difference of 10 or higher was considered clinically meaningful. Results: All of the 30 recruited patients completed treatment and HR-QoL data were available at 3 time points for all patients. The ratio of low, intermediate and high risk patients was 1:9:20. SRT was well tolerated with no acute Grade 3 GI or GU symptoms by NCI CTC v4 (separately reported). Twenty one parameters were studies within the QLQ C30 and PR25 framework. At the end of treatment, only the urinary symptom score showed a clinically meaningful worsening (mean of 20/100 at baseline vs 34/100 at end of treatment, p < 0.001). At 3 months, the urinary symptom score had returned close to baseline (26/100, p = 0.08). There was no clinically meaningful deterioration in the remaining HR-QoL parameters. Conclusions: Patient perception of function and symptoms with once-weekly SRT was good, with only a temporary worsening of the urinary symptom score, and subsequent recovery by 3 months. Compared to baseline scores, other QoL parameters did not show a clinically meaningful difference at end of treatment or at 3 months. Clinical trial information: CTRI/2016/02/006671.
Individual patient level meta-analysis of the performance of the Decipher genomic classifier in high-risk men post-prostatectomy to predict development of metastatic disease.
Authors: Spratt Daniel Eidelberg , Yousefi Kasra , Deheshi Samineh , Ross Ashley , Schaeffer Edward M. , Trock Bruce J. , Karnes Jeffrey , Glass Andrew , Den Robert B. , Dicker Adam , Freedland Stephen J. , Lam Lucia L.C. , du Plessis Marguerite , Choeurng Voleak , Haddad Zaid , Buerki Christine , Davicioni Elai , Weinmann Sheila , Klein Eric A. , Feng Felix Yi-Chung 
Published: March 2017

133 Background: The genomic classifier, Decipher, has been validated to predict risk of metastasis after radical prostatectomy (RP). However, the cohort size and event rate in the previous studies did not allow for a thorough investigation into performance within individual clinicopathologic or treatment subgroups. In this study, we present the first meta-analysis of the performance of the 22-marker genomic classifier in men with prostate cancer (PCa) post-RP. Methods: MEDLINE, EMBASE, and the Decipher genomic resource information database were searched for published reports of men with PCa treated by RP between 2010 and 2016 where the benefit of the Decipher genomic classifier test was assessed. The primary end point was the ability of Decipher to independently improve prognostication of regional or distant metastasis over routine clinicopathologic factors. Meta-analysis was performed with random-effects modeling, and extent of heterogeneity between studies was determined with the I2 test. Results: Five studies (975 total patients, and 855 with individual patient genomic and clinicopathologic data) were eligible for analysis. The median follow-up was 8 years. All patients had clinical high-risk disease, yet 60.9%, 22.6%, and 16.5% of patients were classified as low, intermediate, and high-risk, respectively by Decipher and had 10-year cumulative incidence rates of metastases of 5.5%, 15.0% and 26.7% (p < 0.001), respectively. Adjusting for standard clinicopathologic variables, on multivariable analysis Decipher remained a statistically significant predictor of metastasis (hazard ratio [HR] 1.30 per 0.1 unit, 95% confidence interval [CI] 1.14-1.47, p < 0.001), and the summary HR for metastasis of Decipher across the 5 studies was 1.52 (95% CI 1.39-1.67) per 0.1 unit. Conclusions: The genomic classifier test, Decipher, has the ability to independently improve prognostication of men post-RP, as well as within nearly all clinicopathologic and treatment subgroups. Strong consideration should be given to incorporating the use of genomic testing in clinical decision making and clinical trials to better individualize treatment.
Effects of radium-223 (Ra-223) with docetaxel versus docetaxel alone on bone biomarkers in patients with bone-metastatic castration-resistant prostate cancer (CRPC): A phase I/IIa clinical trial.
Authors: Morris Michael J. , Loriot Yohann , Fizazi Karim , Sweeney Christopher , Ryan Charles J. , Shevrin Daniel H. , Antonarakis Emmanuel S. , Seger Monica , Lu Chengxing , Higano Celestia S. 
Published: March 2017

154 Background: Interactions between metastatic prostate cancer cells, osteoblasts, osteoclasts, and other participants in bone metabolism are complex and result in pathologic bone physiology. Ra-223, a targeted alpha therapy, accumulates at sites of bone metastases and prolongs survival. Ra-223 and docetaxel (D), acting through different mechanisms of action, may have beneficial effects on bone pathophysiology and tumor microenvironment. Prior data suggest treatment with Ra-223 results in favorable alterations in bone biomarkers that are associated with survival. Methods: 53 patients with progressing CRPC and ≥ 2 bone metastases were randomized 2:1 to Ra-223 (55 kBq/kg q6wk × 5) + D (60 mg/m2 q3wk × 10) versus D (75 mg/m2 q3wk with step-down option to 60 mg/m2). Bone resorption (CTX-1, ICTP) and formation (P1NP, bALP) markers, tALP, and PSA were analyzed at wk 19 (after 3 Ra-223 injections) and 3 wk after end of treatment (EOT). Results: Mean % change at wk 19 and EOT are shown (Table). tALP, bALP, P1NP, and PSA declined early during treatment, reaching an average of > 30% decline from baseline by wk 19 in both arms. Mean % declines were greater in the Ra-223 + D versus the D-alone arm at wk 19 and EOT. Bone resorption markers CTX-1 and ICTP showed little decline at wk 19. Conclusions: Ra-223 + D patients had greater % decline in tALP and in bone formation markers bALP and P1NP. Due to small patient numbers and preliminary data, further analysis and correlation with clinical outcomes in a larger study is warranted. Clinical trial information: NCT01106352. [Table: see text]
Polymorphisms of the androgen transporting gene SLCO2B1 and response to abiraterone acetate in mCRPC patients.
Authors: Giacinti Silvana , Bassanelli Maria , Roberto Michela , Strigari Lidia , De Nunzio Cosimo , Aschelter Anna Maria , Marchetti Paolo 
Published: March 2017

174 Background: Abiraterone Acetate (AA), an effective treatment for metastatic castration resistant prostate cancer (mCRPC), is highly variable in its effectiveness and it is well known that form of primary and acquired resistance to this agent, exist. This resistance may partly depend on the increased capacity of CRPC cells to synthesize testosterone and dihydrotestosterone from weak adrenal androgens (i.e. DHEA, DHEA-S) or de novo from cholesterol, in response to a chronic exposition to a low-testosterone environment. The organic anion-transporting polypeptides (OATPs) encoded by SLCO genes, mediate the cellular uptake of many compounds, including adrenal androgens. We hypothesized that germ-line variants of the androgen transporter gene SLCO2B1 (solute carrier organic anion transporter family member 2B1), altering the ability of the prostate cancer cell to stock adrenal precursors, may influence the response to AA of mCRPC patients. Methods: Three single nucleotide polymorphisms (SNPs), exonic SNP rs12422149 and intronic SNPs rs1789693 and rs1077858, were genotyped in a cohort of 21 consecutive patients with mCRPC who were treated with AA at the Sant’Andrea Hospital of Rome, Italy. The SNPs were detected in blood samples using pyrosequencing technique. The median TTBP (Time to Biochemical Progression), PFS (Progression Free Survival) and OS (Overall Survival) was estimated using the Kaplan-Meier method, with 95% CI. To test the association between SNPs and TTBP, PFS and OS the log-rank test was used. Results: The intronic polymorphism of SLCO2B1 rs1077858A > G was associated with TTBP (p = 0.03) and PFS (p = 0.04) of mCRPC patients on AA therapy. Patients carrying the SLCO2B1 rs1077858 risk genotype (GG) exhibited a TTBP that was 8 months shorter than that of patients with the major allele of SNP rs1077858 (AA or GA) (TTBP: A/A+G/A = 12 (95% CI: 12-NA) vs G/G = 4 (95% CI: NA) months). Patients carrying genotype GG of SNP rs1077858 also showed an 11 months shorter PFS on AA therapy than patients with AA or GA genotype (PFS: GG = 5.1 (95% CI:NA) vs AA+GA = 16.7 (95%CI:14.9-NA) months). Conclusions: Genetic variants of SLCO2B1 may function as pharmacogenomic determinants of resistance to AA in mCRPC.