bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating UKCP18-Based weather files for overheating assessment using building simulation: A case study for a flat in london
Authors: Xie Hailun , Eames Matt , Mylona Anastasia , Challenor Peter , De Grussa Zoe , Davies Hywel 
Published: October 2024

Global warming and net zero transition are the two biggest challenges currently faced by the building industry in the UK. While the net zero transition primarily focuses on the problems of energy efficiency and heat decarbonization, the rise of global temperature imposes a significant threat to the health and wellbeing of occupants and the industry is obliged to make buildings climate-resilient by testing their designs using future weather files. To improve the quality of the current weather files, a new project has been commissioned by CIBSE to revisit the data and the methodology employed for creating future weather files and produce new CIBSE weather files using the latest UK Climate Projections released in 2018 (UKCP18). In this study, we evaluate the newly produced weather files for overheating risk using building simulation. Two different batches of weather files were curated. The first batch was produced primarily using the existing methodology for creating the UKCP09 based weather files, with an adjustment to accommodate new features of the UKCP18 and an improved procedure for morphing the solar radiation data. The second batch was created through an improved morphing process to better emulate the characteristics of distributions of climatic variables. The differences between the existing UKCP09 and new UCKP18 based weather files are compared by evaluating overheating metrics. The new weather files enable robust building performance assessment against future climate conditions under different scenarios and will play an important role in designing climate-resilient buildings and delivering a net zero built environment. Practical applications As the extreme weather events resulting from climate change become more frequent and intense, they pose significant challenges to the resilience of the built environment and severe threats to the health and wellbeing of the occupants. Climate data, which serves as the foundation for climate risk assessment, plays a critical role in helping the building sector to achieve climate resilience through the means of performance assessment and the channel of regulatory compliance. In this study, the revised future weather files created using the latest UKCP18 climate projections are presented and evaluated using building simulation, as part of the weather file testing programme for quality assurance. The revision of the CIBSE weather files according to the latest climate science, i.e. UKCP18, will enable the building industry to quantify overheating risks with more accurate climate assumptions and better inform decision making about risk mitigation and climate adaptation.
Yo! Chisme Is Good! Latina/x Girls’ Cultivando Confianza in an After-School Program
Authors: Nuñez Idalia , Ybarra Mónica González , Tissenbaum Catherine Dornfeld , Acosta Brian 
Published: October 2024

Background or Context: Middle-school Girls of Color experience complex systems of relationships, structures, and situations in and out of school spaces. Their experiences, however, are often at the margins or excluded from middle school curricula and after-school programming. In this article, we focus on how young women engage with chisme to liberate themselves from social and academic pressures placed upon them. Purpose and Research Questions: Our study seeks to center and explore the ways of knowing and being of Latina/x middle school girls with particular attention to the role of chisme. We draw on Chicana/Latina feminist perspectives to address the following research questions: (1) How do middle school Latina/x girls define chisme? (2) How and why was chisme enacted or leveraged to co-create a trusting space in an after-school program for middle school Latina/x girls? Research Design: We employed a practitioner research inquiry design to explore chisme as a literacy practice of Latina/x middle-school girls in an after-school program. The after-school program, Latina/x Girlhood Narratives, was implemented in a middle school in a mid-sized, urban city in the Midwest region of the United States. Analytically, we engaged in video data analysis and qualitative coding analysis to examine the data. Results and Conclusions: Three main findings emerged from the study: (1) shared understandings: chismes, rumors, and snitching; (2) todo or la mitad del chisme: a process and product of confianza; and (3) from chismes to liberatory literacy practices of desahogamiento. Our study demonstrates how chisme, in particular, not only was vital to building and deepening confianza, but also allowed access to the girls’ ideas for activities and pedagogies. The field of education must continue to work to make visible the ways in which Latina/x girls engage with themselves and the world in order to sustain better relationships with and for them, and to build pathways for Latina/x girls to see themselves as successful in schools and in society.
Association between patient-reported frailty and nonhome discharge among older patients with acute stroke: A prospective study
Authors: Cui Yanli , Meng Cao , Xiang Lijun , Luo Yansi , Song Xuemei , Cheng Daihong , Ye Jiawei , Zhang Xiaomei 
Published: October 2024

Objective To investigate the association between prestroke frailty and nonhome discharge, prolonged length of stay as well as functional outcomes. Design Prospective observational study. Setting Single urban teaching hospital in Guangzhou, China. Participants Consecutive sample of 271 older patients admitted with acute stroke. Intervention N/A. Main measures A five-item FRAIL scale (0∼5 points) and the stroke severity at onset were measured. The primary outcome of interest was nonhome discharge, with secondary outcomes including prolonged length of stay and worse short-term prognosis. Multivariable logistic regression adjusting for confounding factors was used to determine the association between patient-reported frailty and nonhome discharge, prolonged length of stay, worse short-term prognosis. Results The population had a median age of 68 [interquartile range (IQR), 64∼74)]years, with 50 individuals (18.5%) identified as frail. After adjusting for age, sex, Barthel index, National Institutes of Health Stroke Scale, and Mini-Mental Status Exam score at admission, patients with self-reported frailty were significantly likely to experience nonhome discharge (Odds Ratio [ OR] = 4.788; 95% confidence interval [CI] = 1.272∼18.017; p  = .021), prolonged length of stay ( OR = 4.76; 95% CI  = 1.80∼12.56; p = .002), mRS scores at 30 days ( OR = 6.72;95% CI  = 1.79∼25.20; p = .005) and three months postdischarge and three-month ( OR = 8.94; 95% CI  = 2.10∼38.08; p = .003). Conclusions In older adults with stroke, frailty is associated with nonhome discharge, prolonged length of stay, and worse short-term prognosis, regardless of the stroke severity, cognition, and Barthel index score at admission. FRAIL scale can be used as a practical screening tool in acute care setting by multidisciplinary team in supporting discharge process.
The impact of cannabidiol placebo on amygdala-based neural responses to an acute stressor
Authors: Perry Robin N , Ethier-Gagnon Mikeala A , Helmick Carl , Spinella Toni C , Tibbo Philip G , Stewart Sherry H , Barrett Sean P 
Published: October 2024

Background: Cannabidiol (CBD) impacts brain regions implicated in anxiety reactivity and stress reactivity (e.g., amygdala, anterior cingulate cortex (ACC), anterior insula (AI)); however, placebo-controlled studies are mixed regarding CBD’s anxiolytic effects. We previously reported that CBD expectancy alone can alter subjective, physiological, and endocrine markers of stress/anxiety; however, it is unclear whether these findings reflect altered brain reactivity. This study evaluated whether CBD expectancy independently alters amygdala resting-state functional connectivity (rsFC) with the ACC and AI following acute stress. Method: Thirty-eight (20 females) healthy adults were randomly assigned to receive accurate or inaccurate information regarding the CBD content of a CBD-free oil administered during a single experimental session. Following a baseline resting state MRI scan, participants administered their assigned oil sublingually, engaged in a stress task (serial subtraction with negative feedback) inside the scanner, and underwent another resting state MRI scan. Amygdala rsFC with the ACC and AI was measured during each scan, and the subjective state was assessed at six time points. Outcomes were analyzed using ANCOVA. Results: CBD expectancy (vs CBD-free expectancy) was associated with significantly weaker rsFC between the left amygdala and right ACC ( p = 0.042), but did not systematically alter amygdala-AI rsFC ( p-values > 0.05). We also replicated our previously reported CBD expectancy effects on subjective stress/anxiety in the scanner context. Conclusion: CBD placebo effects may be sufficient to alter neural responses relevant to its purported anxiolytic and stress-relieving properties. Future work is needed to replicate these results and determine whether CBD expectancy and pharmacology interact to alter neural anxiety reactivity and stress reactivity.
Nonunion of the distal one-fourth of the tibia treated by retrograde tibial intramedullary nail
Authors: Zhai Wen-Liang , Xiong Yuan-Fei , Liu Hui , Zhang Jin-Hui , Xu Wei-Zhen , Wu Jin 
Published: October 2024

Objective To evaluate the effectiveness of retrograde tibial intramedullary nail (RTN) in addressing nonunion in the distal one-fourth of the tibia. Methods This retrospective study included consecutive patients who were treated with RTN for nonunion in the distal one-fourth of the tibia between December 2020 and August 2023. Data regarding age, sex, injury mechanism, fracture type, initial fixation method, nonunion duration and type, risk factors, surgical duration, hospital stay, time to bone union, ankle function at final follow-up, and any complications were extracted from hospital records and analysed. Results Five patients in total were included, with previous treatments comprising locking plates and/or external fixation. The mean duration of RTN surgery was 94.0 ± 13.7 min, and mean duration of hospital stay was 9.8 ± 1.9 days. Patients were monitored for 10–18 months post RTN, achieving complete bone healing within a mean of 4.8 months. At the latest follow-up, the mean American Orthopedic Foot and Ankle Society (AOFAS) score was 84.4 ± 6.8 (range, 77–95). No complications, such as infection, reoperation, implant issues, rotational deformity, or shortening were reported. Conclusion RTN emerges as a dependable, minimally invasive, and safe treatment modality for managing nonunion in the distal one-fourth of the tibia.
Early Childhood Routines and Adolescent Health & Well-Being: Associations From a US Urban Cohort of Children With Socioeconomic Disadvantage
Authors: Duh-Leong Carol , Anyigbo Chidiogo , Canfield Caitlin F. , Pierce Kristyn A. , Fierman Arthur H. , Yo Katherine L. , Fuller Anne E. 
Published: October 2024

Purpose To investigate longitudinal associations between the presence of early childhood routines– predictable and repeatable functional practices that promote healthy growth, development, and relationships – and adolescent health outcomes. Design Secondary data analysis. Setting 20 large U.S. cities. Subjects 2943 children with socioeconomic disadvantage from the Future of Families cohort. Measures Routines at age 3 (shared family meals, bedtime routine, daily reading); outcomes later in the same children at age 15 (healthy routines, overall health, psychological well-being). Analysis Descriptive statistics, regression analyses. Results We detected longitudinal associations between early childhood routines and later adolescent routines (increased count of shared family meals by parent report [IRR 1.13, 95% CI: 1.03, 1.24, P = 0.007], bedtime routine and daily reading by adolescent report [aOR 1.34, 95% CI: 1.08, 1.67, P = 0.008; aOR 1.18, 95% CI: 1.01, 1.38, P = 0.04; respectively]). A bedtime routine in early childhood was associated with excellent health in adolescence (aOR 1.42, 95% CI: 1.12, 1.79, P = 0.004]. Adolescent routines were concurrently associated with overall health and psychological well-being. We also detected two longitudinal patterns of associations suggesting multiple mechanisms for how early childhood routines influence later health and well-being. Conclusion Early childhood routines predict adolescent routines, and may contribute to long term adolescent health outcomes. Future studies may promote childhood routines during critical developmental stages as a strength-based strategy to promote long-term health and well-being.
In silico evaluations of phytochemicals from Withania somnifera exhibiting anticancer activity against NAD[P]H-quinone oxidoreductase
Authors: Jahagirdar Sushma , Praveen Kumar Harshini , Bhat Smitha S , Poddar Arpita , Chattaraj Pratim Kumar , Ahmad Sheikh F , Prasad Shashanka K 
Published: October 2024

Background Cancer is a leading cause of death globally and in the US, prompting research into medicinal plants with anticancer properties. Withania somnifera, or Ashwagandha, is one such plants, known for its diverse pharmacological effects. Withaferin A and Viscosalactone B are two compounds found in Ashwagandha with known anticancer activity. The protein NQO1, overexpressed in various cancers, was the focus of this study. Hypothesis and aim We hypothesize that specific phytochemicals in Withania somnifera can effectively interact with and inhibit the NQO1 protein, thereby exhibiting anticancer properties. This study aims to identify these interactions using in silico approaches. Methodology CFDT was performed using the Gaussian 16 program package, followed by QSAR analysis of the compounds in the PASS online web server. The Schrodinger suite was used to carry out ligand and protein preparation, molecular docking, and molecular dynamic simulation to analyse the interaction of these compounds with NQO1 and ADME studies. Protox-II and SWISSADME tools were used to predict the toxicity and blood–brain barrier permeability of the phytochemicals. Results and conclusion CDFT and frontier molecular orbital analyses predicted the stability and reactivity of all the selected molecules. QSAR analysis predicted the biological activity and toxicity of the compounds. Withaferin A exhibited the highest glide gscore (−4.953 kcal/mol) and demonstrated 6 hydrogen bond interactions with NQO1, suggesting its potential as an anticancer agent. Conceptual density functional theory-based analysis suggested the strong electrophilicity of the ligands, further supporting their potential anticancer activities. Viscosalactone B, another phytochemical from Ashwagandha, also showed interactions involving 6 hydrogen bonds with NQO1, with a glide gscore of (−4.593 kcal/mol). Molecular dynamic simulations validated the stability of the Withaferin A-NQO1 complex. ADME-T properties predicted high oral absorption for the selected ligands, indicating that Withaferin A could be a viable orally administered drug.
LncRNA-NEAT1 facilitates autophagy to boost pemetrexed resistance in lung adenocarcinoma via the mir-379-3p/HIF1A pathway
Authors: Hu Wei , Cao Wenjun , Liu Jiheng 
Published: October 2024

Background As a primary chemotherapeutic agent for lung adenocarcinoma (LUAD), pemetrexed (PEM) faces the challenge of resistance development in cancer cells due to its chronic use, which compromises its therapeutic benefits. LncRNA-NEAT1, implicated in the promotion of cancer, is a key player in LUAD. The objective of this study is to explore the contribution of lncRNA-NEAT1 to PEM resistance in LUAD and to dissect the molecular mechanisms involved. Method The expression levels of lncRNA-NEAT1 in LUAD tissues and cells were deciphered using the TCGA database and qRT-PCR. To delve into the functional implications of lncRNA-NEAT1, we engineered plasmids to modulate its expression levels in PEM-resistant A549 cells. PEM resistance in the modified cells was then quantitatively assessed via a panel of assays including cell counting kit-8 (CCK-8), and colony formation, and flow cytometry. To predict the interaction sites between lncRNA-NEAT1 and miR-379-3p, along with the miR-379-3p and hypoxia-inducible factor (HIF1A), we referred to the StarBase and TargetScan databases. The interplay between these RNA molecules was further characterized by RNA immunoprecipitation (RIP) and dual-luciferase reporter assays, while the expression of autophagy-related proteins LC3I, LC3II, and Beclin1 was profiled using western blot (WB). Results Abundant lncRNA-NEAT1 expression was observed in LUAD tissues and cell lines. Its depletion resulted in impeded growth of A549/PEM cells, enhanced apoptotic rates, and a lowered threshold for PEM to exert a half-maximal inhibitory effect. The interplay between lncRNA-NEAT1 and miR-379-3p, as evidenced by dual-luciferase reporter assays, RIP, and qRT-PCR, led to the upregulation of HIF1A. WB and CCK-8 outcomes illustrated that the autophagy and PEM resistance were compromised when HIF1A expression was curtailed by miR-379-3p mimics in A549/PEM cells. The restoration of these effects was observed upon lncRNA-NEAT1-mediated downregulation of miR-379-3p. Conclusion Our study illuminates the role of lncRNA-NEAT1 in LUAD, where it mediates resistance to PEM through the activation of autophagy via the miR-379-3p/HIF1A axis. This work paves the way for new therapeutic strategies for managing PEM resistance in LUAD patients.
Diving deep into lupus: Gastrointestinal involvement insights from the Oman lupus study
Authors: Al-Adhoubi Nasra K , Al Salmi Issa , Al Kaabi Juma , Al-Balushi Farida , Ali Maha , Al Lawati Talal , Al Lawati BSH , Abdwani Reem , Al Shamsi Ali , Al Mashaani Musallam , Jha Divij Krishna , Sayed Sherin , Al-Araimi Tariq , Liyanage Prabha , Al Kalbani Hilal , Al Wahshi Humaid A 
Published: October 2024

Objectives This multicenter longitudinal study investigated the prevalence of gastrointestinal (GI) manifestations in lupus patients and determined the risk factors associated with mortality. Methods This study is part of the Oman Lupus Study, which included 1160 patients who met the classification criteria for systemic lupus erythematosus (SLE) from January 2006 to February 2020. All patients were screened for GI symptoms and involvement. Results We identified 91 patients with GI manifestations, with a prevalence rate of 8.53% in the pediatric group and 7.75% in the adult group, and this difference was not statistically significant ( p = .755). Ischemic colitis was significantly associated with longer disease duration ( p < .001) and positivity for B2-glycoprotein I (B2GPI) autoantibodies ( p < .0001). Moreover, a significant correlation was found between ischemic colitis and hematologic manifestations ( p = .001), lupus nephritis ( p = .007), pulmonary complications ( p = .000-.039), and some cardiac complications ( p = .012-.269). Mortality rates were greater in patients with GI involvement (24.37%), including those with ischemic colitis ( p = .005), chronic peritonitis ( p < .001), and spleen/liver infarction ( p = .001). Sepsis, thrombocytopenia, and different internal organ involvement rates were significantly associated with increased mortality. Conclusion This research provides significant insights into GI manifestations in lupus patients. A higher mortality rate was found to be associated with organ involvement, disease duration, autoantibody profile, and specific complications. Considering this fact, it is vital to prioritize management strategies to improve clinical outcomes in this group of patients.
Cybersecurity lessons from the Vastaamo psychotherapy data breach for psychiatrists and other mental healthcare providers
Authors: Looi Jeffrey CL , Allison Stephen , Bastiampillai Tarun , Maguire Paul A , Kisely Steve , Reutens Sharon , Looi Richard CH 
Published: October 2024

Objective The Vastaamo psychotherapy data breach in Finland is perhaps the largest cybersecurity incident in mental healthcare to date, resulting in significant patient harm. There are specific lessons for mental healthcare providers from an analysis of the incident. Method Case study of this specific electronic health record data breach, based on detailed media reporting. Results The issues raised include: the importance of governance of the cybersecurity of sensitive personal patient data, such as compliance with legislative requirements on privacy and data security; specific security measures such as de-identification of data, data protection via passwords, multi-factor authentication, firewalls and encryption; and timely and effective communication, and support of those who have been affected. Conclusions The implications for mental healthcare providers, including psychiatrists and trainees, are that, within their capability, providers need to assess the efficacy and robustness of cybersecurity of electronic health record systems they use, and carefully consider the information that is recorded to minimise exposures such as in the Vastaamo breach.
Development and validation of the chemotherapy adherence assessment scale (CAAS)
Authors: Prakash G Hari , Kumar D Sunil , PK Kiran , Arun Vanishri , Yadav Deepika 
Published: October 2024

Background Adherence to chemotherapy regimens is crucial for achieving optimal treatment outcomes in cancer patients. However, measuring adherence remains a significant challenge. This study aimed to develop and validate a comprehensive self-report tool for assessing chemotherapy adherence. Methods The Chemotherapy Adherence Assessment Scale (CAAS) was developed through a multi-stage process involving literature review, expert input, and pilot testing. Face validation was conducted with 23 subject experts, and content validity was assessed using the Content Validity Index (CVI). The CAAS was pilot-tested on 28 cancer patients undergoing chemotherapy. Psychometric properties were evaluated through internal consistency analysis (Cronbach’s alpha) and Exploratory Factor Analysis (EFA). Results Face validation revealed 85% agreement among experts regarding grammar, clarity, and content. The CVI was 0.81 for individual items and 0.83 for the overall scale, indicating good content validity. Cronbach’s alpha was 0.789, demonstrating strong internal consistency. The EFA yielded a robust five-factor structure, explaining 94.63% of the total variance. Most items exhibited strong factor loadings (>0.7) and high communalities (>0.7), supporting the construct validity of the CAAS. Conclusions The CAAS demonstrated robust psychometric properties, including good content validity, high internal consistency, and a well-defined factor structure capturing key dimensions of chemotherapy adherence. The CAAS represents a valuable contribution to adherence assessment in oncology settings, with potential applications in clinical practice and adherence interventions.