bluuebunny/crossref_metadata_2025_split huggingface dataset:
SINERGISMO IN VITRO DA ASSOCIAÇÃO ENTRE PRALIDOXIMA E SULFONAMIDAS NA REATIVAÇÃO DA ACETILCOLINESTERASE HUMANA RECOMBINANTE INIBIDA POR PARAOXON
Authors: GARCIA Rômulo Santiago de Lima 
Published: July 2017

<p class="s3"> </p><p class="s9"><span class="s6"><span class="bumpedFont15">Foi realizada a avaliação da capacidade de reativação da acetilcolinesterase humana recombinante inibida </span></span><span class="s6"><span class="bumpedFont15">previamente </span></span><span class="s6"><span class="bumpedFont15">com solução de Paraoxon 2 µM diante de </span></span><span class="s6"><span class="bumpedFont15">pralidoxima em solução a </span></span><span class="s6"><span class="bumpedFont15">100 µM </span></span><span class="s6"><span class="bumpedFont15">em associação com </span></span><span class="s6"><span class="bumpedFont15">onze derivados de sulfonamida em solução a 100 µM em dimetilsulfóxido, a saber, N-(2-clorofenil)benzenossulfonamida, N-(4-fluorofenil)benzenossulfonamida, N-(4-fluorofenil)-4-nitrobenzenossulfonamida, 4-cloro-N-(4-fluorofenil)benzenossulfonamida, N-(3-clorofenil)benzenossulfonamida, N-(3-cloro-2-metilfenil)benzenossulfonamida, 4-cloro-N-fenilbenzenossulfonamida, N-(2-clorofenil)-4-metilbenzenossulfonamida, N-(3-clorofenil)-4-metilbenzenossulfonamida, N-(2-hidroxietil)-4-metil-N-fenilbenzenossulfonamida e /N-(4-nitrofenil)benzenossulfonamida. É a primeira vez que estes derivados de sulfonamida são apresentados </span></span><span class="s6"><span class="bumpedFont15">em associação com a pralidoxima </span></span><span class="s6"><span class="bumpedFont15">como potenciais agentes terapêuticos para o tratamento da intoxicação por co</span></span><span class="s6"><span class="bumpedFont15">mpostos organofosforados. Toda</span></span><span class="s6"><span class="bumpedFont15">s </span></span><span class="s6"><span class="bumpedFont15">as associações avaliadas</span></span><span class="s6"><span class="bumpedFont15"> demonstraram capacidade de reativar a acetilcolinesterase humana recombinante previamente inibida por paraoxon nas doses avaliadas. A</span></span><span class="s6"><span class="bumpedFont15">s</span></span><span class="s6"><span class="bumpedFont15"> molécula</span></span><span class="s6"><span class="bumpedFont15">s</span></span><span class="s6"><span class="bumpedFont15"> com maior potencial de reativação da atividade da acetilcolinesterase </span></span><span class="s6"><span class="bumpedFont15">em associação com a pralidoxima foram </span></span><span class="s6"><span class="bumpedFont15">N-(2-clorofenil)benzenossulfonamida</span></span><span class="s6"><span class="bumpedFont15"> e </span></span><span class="s6"><span class="bumpedFont15">N-(4-fluorofenil)benzenossulfonamida.</span></span></p><p class="s9"> </p>
A aplicabilidade do método das unidades de esforço de produção em uma panificadora: evidências de um estudo de caso
Authors: Lacerda Marcos Suélio Pedone de , Schultz Charles Albino , Walter Fábio 
Published: July 2017

<p>Micro and small enterprises, such as those that typically make up the baking industry, usually lack the resources to invest in complex management tools. A relatively simple alternative to help in cost control and evaluation of productive performance is the Production Effort Units (UEPs - from the Portuguese Unidades de Esforço de Produção) method, which is usually applied to industrial enterprises. This study aims to present consistent evidence that the UEPs method is applicable to a bakery and, to this end, a case study was developed in a small bakery in João Pessoa/PB, using the theoretical basis presented by Bornia (2010) and Kliemann Neto (1994). This work has a descriptive purpose, in which bibliographic research, documentary research and case study were used as methods. The research is classified as qualitative and quantitative, and data collection was based on company documents, timing, unstructured interviews and observation of the production process. The case study demonstrated that the UEPs method was implemented with the use of common spreadsheets, providing the transformation costs and the indicators for the control of productive performance. The results suggest that the UEPs method is applicable to the baking process. </p>
Universidades, produtor e usuário gerando inovação e valor: um caso de sucesso nas redes temáticas da Petrobras
Authors: Ramos Ricardo Rezende , Ferreira Marta Lucia Azevedo 
Published: July 2017

<p>This article discusses the topic of technological cooperation in the Brazilian oil sector from the perspective of academy-industry interactions and open innovation through a case study. We present the management of a cooperative Research and Development (R&amp;D) project between two Brazilian universities, a national medium-sized supplier (producer) and Petrobras (user) within the framework of the C&amp;T-Industry Integration Network in the National Productive Process (RICT), one of the thematic networks created by the operator to enable technological cooperation. We verified that the continuous and systemic interactions among the partners were essential for the development of technological innovation by integrating different fields of knowledge such as industrial networks, automation and mechanics and resulted in a new wireless communication system to be implemented in Petrobras industrial plants. In addition, the project generated value through the generation of specialized human resources, new scientific publications, research agendas, ideas, concepts and solutions, as well as the creation of a technology-based company. Despite the challenges inherent in the management of the cooperative multi-partner R&amp;D project, the previous experience of academic research groups interacting with industry and the learning generated were of great relevance for both Petrobras and the supplier company.</p><p><strong> </strong></p>
Avaliação da integração entre uma plataforma BIM e uma ferramenta de análise estrutural
Authors: Papadopoulos Nicolas Alexandros , Sotelino Elisa Dominguez , Martha Luiz Fernando , Nascimento Daniel Luiz Mattos , Faria Pedro Saieg 
Published: July 2017

<p>Today, the process<strong> </strong>of building an enterprise is based on printed and disconnected documents. There is a global tendency that a project is designed by many companies and different teams, however computer tools used in present time are the same from decades ago. Due to the chang in paradigm, the methodology known as building information modeling (BIM) is little by little finding space in the area of Architecture, Engineering, and Construction (AEC). Moved by the process of transition, this research aims to study and evaluate the integration between a BIM modeling platform and a tool for structural analysis. In order to achieve the expected result, it was used a structural project of a real enterprise, first using traditional methodologies, or in other words, based on 2D indepenendent documents. The project was modeled in 3D with an integrated database according to BIM, with the support of the software <em>Autodesk Revit Structure</em> 2012. The model was then exported to the software for structural analysis <em>Autodesk Robot</em> 2012. Strategies for integration are tested and the best practices are described in detail. The results found suggest the use of the methodology in structural analysis is promising, and its implementation must be seriously considered in Brazil. </p>
PERFORMANS REPRODUKSI SAPI PERANAKAN ONGOLE DAN PERANAKAN LIMOUSIN DI KECAMATAN PADANG KABUPATEN LUMAJANG
Authors: Akriono Muhammad Luqman , Wahyuningsih Sri , Ihsan M Nur 
Published: July 2017

The purpose of this research was conducted to evaluate reproductive performance of Ongolecrossbreed cattle andLimousin crossbreed Â inPadang, Lumajang Regency. The material used on this research were 50 heads of Limousin crossbreed cattle and 50 heads ofOngoleÂ crossbreed cattle.The method used in this research was purposive sampling survey.The data were analyzed by t-test unpaired on Service per Conception (S/C), Days Open (DO), Calving Interval (CI).Conception Rate (CR) and Fertility IndexÂ (FI)were analyzed by descriptive.The results showed thatS/C, DO, CR, CI and FI of Ongole crossbreed cattle were 1,42Â±0,70; 107,34Â±32,38days, 70%; 399,04Â±39,97 days;66,95and for Limousine crossbreed were 1,62Â±0,76; 107,34Â±32,38days, 52%; 416,04Â±44,09days;26,80, respectively. Â It was concluded that there was difference of reproductive performance between Ongole crossbreed cattle and Limousine crossbreedÂ andÂ reproductive performance of Ongole crossbreed cattle was better than Limousine crossbreed cattle.Â Keywords: Reproductive performance, Ongole crossbreed Cattle,Limousin crossbreed CattleÂ
JUMLAH LEUKOSIT DAN DIFFERENSIASI LEUKOSIT AYAM BROILER YANG DIBERI MINUM AIR REBUSAN KUNYIT
Authors: Jannah Prastiwanti Nur , Sugiharto Sugiharto , Isroli Isroli 
Published: July 2017

This study aimed to assess the effect of boiled turmeric water on the number of leukocyte and differentiation leukocyte of broilers. The study was conducted in Oktober - November 2016. The material used was 200Day Old Chick Â (DOC) Â of broiler with initial weight 41.48 Â± 0.99 g. Feed used was a commercial feed with code B-11S to phase stater and BR-1AJ for the finisher phase and turmeric. The design used in this study was completely randomized design (CRD) with 5 treatments and 5 replicates containing 8 DOC in each. The treatment consisted of T0 (100% water), T1 (75% water + 25% boiled turmeric water), T2 (50% water + 50% boiled turmeric water), T3 (25% water + 75% boiled turmeric water), T4 (100% boiled turmeric water).The results showed that boiled turmeric water give significantly affect the percentage of lymphocytes and eosinophils (P<0,05), but did not significantly affect the total number of leukocytes, percentage of heterophile and monocytes (P>0,05). The conclusion from this study is that the boiled turmeric water in the drinking water of broilers was able to improve white blood profile, that indicated by the number of leukocyte and percentage of lymphocytes and eosinophils.Â Keywords: Turmeric, leuycocyte, differential leucocyte, broiler
Use of Proteomics To Investigate Kidney Function Decline over 5 Years
Authors: Carlsson Axel C. , Ingelsson Erik , Sundström Johan , Jesus Carrero Juan , Gustafsson Stefan , Feldreich Tobias , Stenemo Markus , Larsson Anders , Lind Lars , Ärnlöv Johan 
Published: July 2017

Background and objectives
Using a discovery/replication approach, we investigated associations between a multiplex panel of 80 circulating proteins associated with cardiovascular pathology or inflammation, and eGFR decline per year and CKD incidence.

Design, setting, participants, & measurements
We used two cohorts, the Prospective Investigation of the Vasculature in Uppsala Seniors Study (PIVUS; n=687, mean age of 70 years, 51% women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n=360 men, mean age of 78 years), with 5-year follow-up data on eGFR. There were 231 and 206 incident cases of CKD during follow-up in the PIVUS and ULSAM studies, respectively. Proteomic profiling of 80 proteins was assessed by a multiplex assay (proximity extension assay). The assay uses two antibodies for each protein and a PCR step to achieve a high-specific binding and the possibility to measure multiple proteins in parallel, but gives no absolute concentrations.

Results
In the discovery cohort from the PIVUS Study, 28 plasma proteins were significantly associated with eGFR decline per year, taking into account the multiple testing. Twenty of these proteins were significantly associated with eGFR decline per year in the replication cohort from the ULSAM Study after adjustment for age, sex, cardiovascular risk factors, medications, and urinary albumin-to-creatinine ratio (in order of significance: TNF-related apoptosis-inducing ligand receptor 2*, CD40L receptor, TNF receptor 1*, placenta growth factor*, thrombomodulin*, urokinase plasminogen activator surface receptor*, growth/differentiation factor 15*, macrophage colony-stimulating factor 1, fatty acid-binding protein*, cathepsin D, resistin, kallikrein 11*, C-C motif chemokine 3, proteinase-activated receptor 1*, cathepsin L, chitinase 3-like protein 1, TNF receptor 2*, fibroblast growth factor 23*, monocyte chemotactic protein 1, and kallikrein 6). Moreover, 11 of the proteins predicted CKD incidence (marked with * above). No protein consistently predicted eGFR decline per year independently of baseline eGFR in both cohorts.

Conclusions
Several circulating proteins involved in phosphate homeostasis, inflammation, apoptosis, extracellular matrix remodeling, angiogenesis, and endothelial dysfunction were associated with worsening kidney function. Multiplex proteomics appears to be a promising way of discovering novel aspects of kidney disease pathology.
Submandibular gland sialolith of unusual size
Authors: Kandel Santosh , Pandey Bhuwan Raj , Poudel Prakash 
Published: July 2017

Introduction: Sialolithiasis is the most common disease of the salivary glands. Majority of sialoliths occur in the submandibular gland and is a common cause of acute and chronic infections of the gland. The size varies from one mm to one cm. Size greater than 15 mm are considered unusual or giant sialolith.
Case report: We present a case of an unusual size sialolith of 16 mm in submandibular gland duct which was removed via transoral incision. The aim of presenting this case report is to understand etio-pathogenesis, clinical presentation and management of submandibular sialolithiasis.
Conclusion: Submandicular sialolithiasis of more than 15 mm in size though rare are not uncommon. They can be managed intraorally if situated at or near the orifice.
Pengendalian Kualitas Kertas Dengan Menggunakan Statistical Process Control di Paper Machine 3
Authors: Devani Vera , Wahyuni Fitri 
Published: July 2017

Purpose of this research is to determine types and causes of defects commonly found in Paper Machine 3 by using statistical process control (SPC) method. Statistical process control (SPC) is a technique for solving problems and is used to monitor, control, analyze, manage and improve products and processes using statistical methods. Based on Pareto Diagrams, wavy defect is found as the most frequent defect, which is 81.7%. Human factor, meanwhile, is found as the main cause of defect, primarily due to lack of understanding on machinery and lack of training both leading to errors in data input.
Accuracy and repeatability of long-bone replicas of small animals fabricated by use of low-end and high-end commercial three-dimensional printers
Authors: Cone Jamie A. , Martin Thomas M. , Marcellin-Little Denis J. , Harrysson Ola L. A. , Griffith Emily H. 
Published: July 2017

Abstract
OBJECTIVE To assess the repeatability and accuracy of polymer replicas of small, medium, and large long bones of small animals fabricated by use of 2 low-end and 2 high-end 3-D printers.
SAMPLE Polymer replicas of a cat femur, dog radius, and dog tibia were fabricated in triplicate by use of each of four 3-D printing methods.
PROCEDURES 3-D renderings of the 3 bones reconstructed from CT images were prepared, and length, width of the proximal aspect, and width of the distal aspect of each CT image were measured in triplicate. Polymer replicas were fabricated by use of a high-end system that relied on jetting of curable liquid photopolymer, a high-end system that relied on polymer extrusion, a triple-nozzle polymer extrusion low-end system, and a dual-nozzle polymer extrusion low-end system. Polymer replicas were scanned by use of a laser-based coordinate measurement machine. Length, width of the proximal aspect, and width of the distal aspect of the scans of replicas were measured and compared with measurements for the 3-D renderings.
RESULTS 129 measurements were collected for 34 replicas (fabrication of 1 large long-bone replica was unsuccessful on each of the 2 low-end printers). Replicas were highly repeatable for all 3-D printers. The 3-D printers overestimated dimensions of large replicas by approximately 1%.
CONCLUSIONS AND CLINICAL RELEVANCE Low-end and high-end 3-D printers fabricated CT-derived replicas of bones of small animals with high repeatability. Replicas were slightly larger than the original bones.
Transnationalism and the Syrian Migrant Community: The Case of the 1925 Syrian Revolt
Authors: Bailony Reem 
Published: July 2017

This article explores how the mahjar press of New York City engaged with the Syrian Revolt of 1925. Building upon Benedict Anderson’s well-known theories of imagined and long-distance nationalisms, as well as more recent debates on transnationalism, this article is part of a larger attempt to geographically decenter the study of the 1925 revolt in order to contribute to a better understanding of the ways in which nationalism and anti-colonialism were negotiated through a dialectical relationship between the homeland and the diaspora. It argues that divergent views of the revolt are better understood by framing its construction in the press in terms of: 1.) an expression of trans-border, and yet particular, loyalties, and 2.) a reflection of the diaspora’s ambiguous place in the new international order set up by the League of Nations.
La frontière dans tous ses états
Authors: Bennafla Karine 
Published: July 2017

Ce numéro revient sur la crise des frontières d’État amorcée avec la vague de contestation populaire arabe en 2011 et la multiplication des conflits qui a suivi, à l’origine d’un processus de dislocation territoriale ou tout au moins d’une déstabilisation généralisée des bordures territoriales. Ce tournant frontalier au Maghreb et au Moyen-Orient avait été brièvement abordé lors d’un numéro de Confluences Méditerranée en 2015 intitulé « Crises sans frontières » 1 . L’article pointait les processus de dé/re-territorialisation à l’œuvre dans une région aux contours élargis sous l’effet des guerres, des multiples interventions des armées étrangères ou de mercenaires, des mouvements de réfugiés, mais aussi avec la diffusion d’une nouvelle idéologie, à forte résonance spatiale, par le groupe autoproclamé État islamique (Daech). Cette idéologie était perceptible à travers l’annonce de la restauration du califat en juin 2014 et le refus explicite des frontières « coloniales » instaurées par les accords Sykes-Picot (1916).
Frontière et territorialité dans la perception du monde selon l’État turc
Authors: Kaya Ugur 
Published: July 2017

Le principe essentiel de la politique étrangère turque depuis sa fondation républicaine, consiste à garder le statu quo territorial. Parallèlement, l’État turc conduit une politique réfléchie de rupture avec les régions voisines, notamment avec « l’Orient » arabo-musulman. Cette rupture engendre en Turquie un caractère politique que je qualifierai d’insulaire. Les frontières demeuraient jusqu’alors une ligne de délimitation entre diverses zones géopolitiques servant à bloquer le passage. Avec la fin de la guerre froide, à la recherche d’une nouvelle stature internationale, l’État turc développe un nouveau paradigme politique, modifiant les représentations du monde et la gestion des frontières. La Turquie est envisagée comme un empire logistique local, sous la protection d’un empire global avec le leadership américain. Mais depuis le gouvernement Erdogan, l’idée d’un empire local en harmonie avec l’empire global pour la Turquie laisse place à l’idée d’un empire à vocation universelle protecteur et régulateur, face à un empire occidental déstabilisateur.
À l’ombre de Mossoul : l’Irak entre hyper-fragmentation et frontières incertaines
Authors: Benraad Myriam 
Published: July 2017

Au-delà de nombreux revers militaires et humains, l’État islamique est encore loin d’être totalement défait en Irak. Depuis la reprise d’un certain nombre de ses fiefs historiques par les forces irakiennes soutenues par la coalition (Tikrit, Ramadi, Fallouja…), le groupe jihadiste est parvenu à se redéployer en de nombreux points du territoire, revenant à la clandestinité et ses méthodes éprouvées : multiplication des attaques armées, assassinats ciblés, attentats sanglants. Alors que la bataille de Mossoul semble lentement se refermer, au terme de huit mois de destructions sans précédent – cette bataille fut l’une des plus meurtrières du conflit depuis 2003 – la crise irakienne se poursuit quant à elle. La séquence jihadiste a surtout mis en lumière l’état d’extrême fragmentation du paysage sociopolitique local, à commencer par la composante arabe sunnite qui peine à entrevoir l’avenir et une alternative politique crédible au « califat ». L’État islamique prétendait « effacer les frontières » en s’emparant du pouvoir. Certes, cet objectif s’est en partie réalisé, mais il s’est aussi traduit par le tracé de nouveaux « murs » intérieurs et extérieurs, physiques et plus symboliques. L’article qui suit interroge cette hyper-fragmentation et les potentialités d’une reconstruction nationale post-jihadiste.
Penser la spatialité en Islam militant : le cas des manuels scolaires de géographie de l’État islamique (2015-2016)
Authors: Cimino Matthieu 
Published: July 2017

Parmi les référentiels de mobilisation du groupe « État islamique », la question de l’oblitération matérielle et immatérielle de l’ordre frontalier issu des accords Sykes-Picot (1916) semble jouer un rôle prépondérant : en effet, au cœur de l’imaginaire politique du groupe s’inscrit l’impératif de revitalisation califale et, partant, la restauration de l’unité politique et spatiale d’un monde islamique idéalisé. Cet article, issu d’un travail de terrain conduit en 2015 et 2016, explore les stratégies de conceptualisation et de diffusion de l’idéologie spatiale de Daech à partir de l’étude d’ouvrages scolaires de géographie, collectés dans et autour des territoires tenus par le groupe.
Réflexions géopolitiques sur les dynamiques frontalières contemporaines au Moyen-Orient et au Sahel
Authors: Foucher Michel 
Published: July 2017

La comparaison des dynamiques frontalières en Orient et en Afrique saharo-sahélienne révèle plusieurs traits communs : des tracés contemporains de facture largement exogène, une appropriation ultérieure par les États indépendants et la persistance de tensions internes exploitées par des forces internationalisées et transfrontalières.
Crise de l’État, crise des frontières : une nouvelle question d’Orient ?
Authors: Goutalier Marc 
Published: July 2017

Les révoltes populaires de 2011 ont agi comme un révélateur de l’usure avancée du modèle autoritaire et centralisé qui était jusque-là propre à tous les Etats arabes. Elles ont produit de puissantes dynamiques en faveur d’une redéfinition du consensus territorial hérité des temps coloniaux, et dont les populations avaient auparavant toujours été écartées. Outre l’émergence d’une opinion publique et l’ingérence accrue des puissances étrangères, des acteurs infra-étatiques dont les projets et le discours ne sont plus en correspondance avec la carte politique des États-nations ont profité de l’affaiblissement des autorités centrales pour se territorialiser. La remise en cause profonde des frontières induite par ces bouleversements incite à repenser la carte, ou à tout le moins les modes de gestion politiques de l’espace au Moyen-Orient et en Afrique du Nord.