bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimised treatment of patients with enlarged lateral lymph nodes in rectal cancer: protocol of an international, multicentre, prospective registration study after extensive multidisciplinary training (LaNoReC)
Authors: van Geffen Eline G M , Sluckin Tania C , Hazen Sanne-Marije J A , Horsthuis Karin , Intven Martijn , van Dieren Susan , Beets Geerard , Lange Marilyne M , Taggart Melissa W , Beets-Tan Regina G H , Marijnen Corrie A M , Konishi Tsuyoshi , Tanis Pieter J , Kusters Miranda 
Published: October 2024

IntroductionInadequate treatment of enlarged lateral lymph nodes (LLNs) in rectal cancer patients is associated with an increased lateral local recurrence (LLR) risk, despite neoadjuvant treatment and total mesorectal excision (TME) surgery. There is a promising role for LLN dissection (LLND) to lower this risk, but this challenging procedure requires appropriate training. This study protocol describes a prospective evaluation of oncological outcomes after standardised treatment based on multidisciplinary training, thereby aiming for a 50% reduction in LLR rate.Methods and analysisA prospective registration study will be opened in hospitals in which the involved multidisciplinary team members (radiologists, radiation oncologists, surgeons and pathologists) have received dedicated training to enhance knowledge and awareness of LLNs and in which standardised treatment including LLND has been implemented. Patients with rectal cancer and at least one enlarged LLN (short-axis ≥7.0 mm), or intermediate LLN (short-axis 5.0–6.9 mm) with at least one malignant feature on primary MRI, evaluated by a trained radiologist, are eligible. Patients will undergo neoadjuvant treatment by trained radiation oncologists, followed by TME surgery in combination with a minimally invasive, nerve-sparing LLND performed by trained surgeons. LLND specimens are evaluated by trained pathologists or grossing assistants. The primary outcome is LLR rate 3 years postoperatively. Secondary outcomes are morbidity, disease-free survival, overall survival and quality of life. To demonstrate a significant reduction in LLR rate from 13% (based on historical control data) to 6% after optimised treatment, 200 patients with enlarged LLNs are required.Ethics and disseminationThe medical ethics board of the Vrije Universiteit Medical Centre (VUMC), the Netherlands, approved the study on 23 November 2022 (reference: 2021.0524). Participating centres must obtain local approval and participants are required to provide written informed consent. Results obtained from this study will be communicated via peer-reviewed medical journals and presentations at conferences.Trail registration numberNCT04486131, 24 July 2020,https://clinicaltrials.gov/ct2/show/NCT04486131.
Cross-sectional exploratory survey among health researchers in Europe on the awareness of and barriers affecting the use of an evidence-based research approach
Authors: Van Eerdenbrugh Sabine , Pingani Luca , Prevendar Tamara , Lantta Tella , Zajac Joanna , Prokop-Dorner Anna , Brandão Maria Piedade , Poklepović Peričić Tina , van Hoof Joost , Lund Hans , Bała Małgorzata M 
Published: October 2024

ObjectivesThis exploratory study was conducted to find out how well the concept of evidence-based research (EBR) is known among European health researchers with substantial clinical research experience, and which barriers affect the use of an EBR approach. The concept of EBR implies that researchers use evidence synthesis to justify new studies and to inform their design.DesignA cross-sectional exploratory survey study.Setting and participantsThe survey was conducted among European health researchers. Respondents included 205 health researchers (physicians, nurses, dentists, allied health researchers and members of other professions involved in health research) with a doctoral degree or at least 5 years of research experience.Primary and secondary outcome measuresThe primary outcome measures were the level of awareness of the concept of EBR and the presence of barriers affecting the use of an EBR approach. Secondary outcome measures include correlations between sociodemographic characteristics (eg, profession) and awareness of EBR.ResultsWe discovered that 84.4% of the respondents initially indicated their awareness of the concept of EBR. Nevertheless, 22.5% of them concluded that, on reading the definition, they either do not know or do not fully comprehend the concept of EBR. The main barriers affecting the use of an EBR approach were related to organisational issues, such as not being attributed resources (30.5% of the respondents), time (24.8%) or access to implement it (14.9%).ConclusionsDespite the limitations, this study clearly shows that ongoing initiatives are necessary to raise awareness about the importance of implementing the EBR approach in health research. This paper contributes to a discussion of the issues that obstruct the implementation of the EBR approach and potential solutions to overcome these issues, such as improving the knowledge and skills necessary to practice the EBR approach.
Constraining the entropy corrected (m, n)-type pilgrim dark energy in fractal cosmology
Authors: Sardar Alok , Debnath Ujjal 
Published: October 2024

AbstractThis study explores the impact of introducing particle and future event horizon as infrared (IR) cutoff on (m, n)-type entropy corrected versions of pilgrim dark energy. We investigate (m, n)-type power-law entropy corrected pilgrim dark energy in a flat fractal platform by considering a non-interacting scenario with cold dark matter. Then, our focus shifts to (m, n)-type logarithmic entropy corrected pilgrim dark energy. We derive the evolution of some relevant cosmological parameters and cosmological planes. Finally, we constrain the model parameters using $$H(z)+$$

H
(
z
)
+

BAO combined observational data from the DA and BAO methods. For statistical analysis, we apply the $$\chi ^2$$

χ
2

-minimization technique (equivalent to the maximum likelihood method) to estimate the best-fit value of the model parameters. We incorporate public Cosmo Hammer (EMCEE) Python package code to perform the MCMC method. Finally, we display the plot of cosmological parameters and cosmological plane and analyze the triangular contour plot by using the optimal values of the model parameters.
The Co‐Occurrence of Medullary and Papillary Thyroid Carcinoma—A Literature Review Based on a Case Report
Authors: Nordhausen Katharina , Deutschbein Timo , Heinrichs Volker , Weyhe Dirk , Tabriz Navid 
Published: October 2024

Background: The co‐occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is thought to be a rare phenomenon. Here, we present a patient undergoing surgery due to a suspected MTC. Histopathological workup confirmed the suspected diagnosis but also described an incidental PTC in the contralateral lobe with lymph node metastasis in the central cervical compartment.Case Presentation: A 58‐year‐old female presented with thyroid nodules and significantly elevated levels of calcitonin and carcinoembryonic antigen (CEA). She underwent total thyroidectomy along with central and bilateral lymph node dissection. Histology revealed a MTC of 20 mm and a BRAF V600E‐positive PTC of 11 mm with central cervical lymph node metastasis. Postoperatively, ablative radioiodine therapy was performed. Two months later, both calcitonin and CEA were normalized.Conclusion: Simultaneous occurrence of MTC and PTC seems to be rare, but recent literature suggests that simultaneous occurrence is probably more frequent than initially thought. Preoperative calcitonin can be helpful in the diagnostic workup of thyroid nodules. Due to different treatment strategies, precise histological differentiation of potential lymph node metastasis is essential.
The Use of Physical Activity Mobile Apps Improves the Psychological State of Adolescents: A Randomized Controlled Trial
Authors: Mateo-Orcajada Adrián , Vaquero-Cristóbal Raquel , Abenza-Cano Lucía 
Published: October 2024

Mobile applications positively influence the practice of physical activity in adolescents, but the effect of this improvement on the psychological state and the addictive use of technologies in this population is unknown. For this reason, the aims of the present investigation were to establish the differences in psychological variables and problematic mobile phone use by adolescents after a 10‐week intervention with mobile apps, according to gender and the different mobile applications used. A randomized controlled trial was conducted in Spain with 400 adolescents aged 12–16 years (mean age: 13.96 ± 1.21 years old) whose physical activity level, satisfaction of competence, autonomy, and relatedness, life satisfaction, and addictive use of the mobile phone were measured. Two measurements were taken, with a 10‐week intervention period in between. During the intervention, adolescents in the experimental group (EG) must use one of the selected mobile applications (Strava, Pacer, MapMyWalk, or Pokémon‐Go) a minimum of 3 times per week, covering the distance indicated for each week. The use of the mobile applications was randomized for each class group, and an explanation was given to the adolescents prior to the start of the intervention. The results showed that EG showed a significant improvement in the psychological variables (p = 0.003 − 0.036) compared to the control group and also a decreased problematic mobile phone use (p = 0.004). Specifically, females in the EG increased autonomy (p = 0.010), relatedness (p = 0.019), and life satisfaction (p = 0.020), while males improved relatedness (p = 0.021) and competence (p = 0.018). In addition, the different applications used could influence autonomy, relatedness, and problematic mobile phone use. To conclude, the use of mobile step trackers could be useful to maintain an adequate psychological state of the adolescent population without increasing the addictive or problematic use of these technologies.Trial Registration: ClinicalTrials.gov identifier: NCT04860128.
“Nursing My Own Work Destiny”: A Concept Analysis of Basic Psychological Need Crafting
Authors: Kotze Rutger , Vaart Leoni van der , Oosthuysen Elrie 
Published: October 2024

Background: Need crafting is becoming increasingly important in research and nursing practice. Nurses who engage in need crafting may experience optimal mental health because of the optimal satisfaction of basic psychological needs.Purpose: The concept is not well defined in the work context, and this study aimed to clarify and develop it further. Following Walker and Avant’s procedure, we systematically analyzed the concept. We also constructed model, borderline, and contrary cases relevant to the nursing context.Methods: The authors searched Web of Science, ScienceDirect, and Scopus—using primary and secondary search terms—and identified English records published from 2010 to 2022.Results: Need crafting is defined as a proactive, self‐directed process in which employees make behavioral or cognitive changes or seek environments that affect their need‐based experiences in the work environment. When crafting, employees would also consider whether an approach (to satisfy the need for autonomy, competence, and relatedness) or avoidance (to avoid frustration with the need for autonomy, competence, and relatedness) is necessary. Need crafting involves intentional thought or action to optimize need‐based experiences in a personalized and unique way. This approach emphasizes a proactive stance toward need fulfillment at work. The concept analysis (CA) also yielded antecedents (at the individual, team/group, leadership, and organizational/contextual levels) and consequences (from affective, behavioral, and cognitive perspectives) of need crafting.Conclusion: This CA has significantly clarified the construct of need crafting within the work context and provided a deeper understanding of its specific application in nursing. By establishing a robust conceptual foundation, this study offers valuable insights for both researchers and practitioners, contributing to a broader work context and, more specifically, to nursing management. These insights have important implications for enhancing nurses’ well‐being and, ultimately, the quality of healthcare delivery.
Prevalence and Factors Associated With Abnormal Cerebroplacental Ratio Among Women With Hypertensive Disorders of Pregnancy at a Tertiary Referral Hospital in Southwestern Uganda
Authors: Ibrahim Suada Suleiman , Tornes Yarine Fajardo , Kayondo Musa , Tsongo Fidel Kasereka , Mugyenyi Godfrey Rwambuka , Ngonzi Joseph , Lugobe Henry Mark , Mugisha Julius Sebikali , Tibaijuka Leevan 
Published: October 2024

Background: Hypertensive disorders of pregnancy (HDP) are associated with placental insufficiency and adverse perinatal outcomes—over half (58.9%) of women with HDP at Mbarara Regional Referral Hospital (MRRH) have adverse perinatal outcomes. The cerebroplacental ratio (CPR) is an important predictor and prevents approximately 30% of these adverse perinatal outcomes. We determined the prevalence and factors associated with abnormal CPR among women with HDP at MRRH.Methods: We conducted a cross‐sectional study from December 2022 to May 2023 at the high‐risk obstetrics unit of MRRH. We consecutively enrolled all women with hypertensive disorders and gestational ages ≥ 26 weeks and performed obstetric Doppler studies to document the pulsatility index (PI) of the umbilical artery (UA) and middle cerebral artery (MCA) and then calculated the CPR as a ratio of the MCA‐PI and UA‐PI. The prevalence of women with an abnormal CPR ≤ 1.0 was expressed as a percentage. We used robust modified Poisson regression analysis to determine the factors associated with abnormal CPR.Results: We enrolled 128 women with hypertensive disorders in pregnancy, with a mean age of 28.8 ± 6.3 years. Of these, 67 (52.3%) had abnormal CPR. The factors associated with abnormal CPR were severe pre‐eclampsia (adjusted prevalence ratio (aPR): 5.0, 95% CI: 1.28, 29.14) and eclampsia (aPR: 5.27, 95% CI: 1.11, 34.27).Conclusion: On average, half of the women with hypertensive disorders have abnormal CPR. Women with severe pre‐eclampsia or eclampsia are more likely to have abnormal CPR. Obstetric Doppler studies with CPR may be warranted for all pregnant women with severe pre‐eclampsia and eclampsia. We recommend further research to assess perinatal outcomes among those with and without abnormal CPR to profile women with HDP at increased risk of adverse perinatal outcomes.
Neoadjuvant Intratumoral Plasmid IL-12 Electro-Gene-Transfer and Nivolumab in Patients with Operable, Locoregionally Advanced Melanoma
Authors: Tarhini Ahmad A. , Eroglu Zeynep , Eljilany Islam , Zager Jonathan S. , Gonzalez Ricardo J. , Sarnaik Amod A. , Cruse Carl Wayne , Khushalani Nikhil I. , De Aquino Deanryan B. , Abraham Edith , Acevedo Diana M. , Richards Allison , Schell Michael J. , Kalos Denise , Chen Pei-Ling , Messina Jane L. , Canton David A. , Sondak Vernon K. 
Published: October 2024

Abstract

Purpose:
Intratumoral tavokinogene telseplasmid delivered by electroporation (TAVO-EP) results in localized expression of IL-12 within the tumor microenvironment (TME). This study evaluated neoadjuvant TAVO-EP combined with intravenous nivolumab followed by surgery and adjuvant nivolumab in patients with operable, locoregionally advanced melanoma.

Patients and Methods:
The neoadjuvant phase comprised up to 3 × 4-week cycles during which TAVO-EP was given intratumorally on days 1, 8, and 15 (optional) concurrently with 480 mg nivolumab intravenously on day 8 of each 4-week cycle. Surgery followed, and adjuvant nivolumab was initiated after surgery. The primary endpoint was pathologic complete response (pCR). Secondary endpoints included major pathologic response (MPR; pCR or near pCR).

Results:
Sixteen patients were enrolled, and the preoperative radiological response rate was 63%. One patient declined surgery after experiencing a significant clinical response. Among the remaining 15 patients, the pCR rate was 60% and the MPR was 80%. No patient with MPR has had disease recurrence with a median follow-up from the date of surgery of 15.4 months. At baseline, most patients exhibited low CD8+ tumor-infiltrating lymphocytes, PD-L1, and IFN-γ gene expression signature. There was enhanced immune activation following treatment in the TME and blood, including increased immune-related gene expression, CD8+ tumor-infiltrating lymphocytes, and proliferating immune cell subsets.

Conclusions:
The clinical efficacy of neoadjuvant intratumoral TAVO-EP + nivolumab is promising with 80% of patients achieving an MPR. Evidence of potent immune activation both systemically and within the TME along with a favorable safety profile supports the activity of local IL-12 and anti–PD-1 based regimens.
Pensando corpo, gênero e sexualidade em contexto sado-fetichista. Thinking body, gender and sexuality in sado - fetishist context
Authors: Silva Marcelle Jacinto da , Paiva Antonio Crístian Saraiva 
Published: October 2024

Este artigo tem como fio condutor parte do meu material etnográfico proveniente de dissertação em andamento, a qual tem como foco narrativas sobre repertórios de experiências com/em práticas sócio-sexuais de sado-fetichismo, mais especificamente práticas de feminização no BDSM, cujos protagonistas relatam em blogs pessoais e entrevistas suas experiências e performances eróticas, reinventando seus próprios corpos e performatizando estereótipos de gênero. Propomos discutir como os atores se engajam no processo de feminização, como pensam e elaboram suas experiências de vestir-se de outro gênero, como vivenciam performances de gênero inseridas no contexto das práticas do sadomasoquismo erótico ou BDSM, e como corpo, sexualidade e gênero podem ser problematizados a partir da observação dessas narrativas.

This article has the thread of my ethnographic material from dissertation in progress, which focuses on narrative repertoire of experience with / in social and sexual practices of sado- fetishism, specifically male feminization, whose protagonists report on personal blogs and interviews their experiences and erotic performances, reinventing their own bodies and performing gender stereotypes. We propose to discuss how actors engage in feminization process, how they think and prepare their experiences to dress up another gender, such as experience included gender performances in the context of BDSM or erotic sadomasochism, and as the body, sexuality and gender can be problematized from the observation of these narratives.
A new species of Buresilia (Opiliones, Phalangiidae) from Turkey
Authors: KURT KEMAL , KURT PINAR 
Published: October 2024

A new harvestman species, Buresilia gumushanensis sp. nov. (Opiliones: Phalangiidae), is described based on male specimens collected from Gümüşhane province, Turkey. Detailed descriptions, diagnostic features and pictures of the new species are provided, together with mitochondrial cytochrome c oxidase subunit I (COI) sequences. The phylogenetic tree constructed using the COI gene region revealed the phylogenetic position of the genus Buresilia within the family Phalangiidae. In addition, the new species is compared with known species of the genus Buresilia.
Executive evaluative ambivalence: A more balanced look
Authors: Julian Scott , Quinn-Grzebyk Tamme , Karaca Ayse 
Published: October 2024

Executive evaluative ambivalence influences how firms act and respond to strategic issues but research on what is associated with such ambivalence has languished. Prior research focused on perspective complexity to the relative neglect of diagnostic effort, leaving imbalanced our understanding of not only executive evaluative ambivalence, but also issue diagnosis and sensemaking in general. Considering factors relating to both the subject of diagnosis (executives) and the object of diagnosis (the strategic issue), we test our hypotheses with pre-existing data addressing how executives evaluated a period of economic environmental equivocality. We find that executive job demands and perceived issue time pressure exhibited inverted-U relationships, and that a higher proportion of external executives and a narrower target market focus exhibited positive relationships, with executive evaluative ambivalence. We also confirm and extend previous perspective complexity research and close by addressing implications for research and practice. JEL Classification: M10, M12, M19
Medial Joint Opening in the Operated Knee After Unilateral High Tibial Osteotomy: Risk of Osteoarthritis and Future Surgery in the Operated and Nonoperated Knee
Authors: Gimm Geunwu , Ji Hyunjun , Ro Du Hyun , Lee Myung Chul , Han Hyuk-Soo 
Published: October 2024

Background: High tibial osteotomy (HTO) modifies the mechanics of the affected knee but can also affect the nonoperated knee. However, no research has reported on the prognosis and risk factors related to the nonoperated knee after unilateral HTO. Purpose: To assess the radiological parameters associated with osteoarthritis (OA) progression and the need for surgery in the nonoperated knee after unilateral HTO, with concurrent assessment of the operated knee. Study Design: Case series; Level of evidence, 4. Methods: The medical charts of 197 patients with knee OA who underwent unilateral HTO between March 2007 and December 2020 were retrospectively investigated. Radiological parameters such as the Kellgren-Lawrence grade, weightbearing line ratio, joint line convergence angle (JLCA), and joint line obliquity angle were assessed preoperatively and 1 year postoperatively. Results: The mean follow-up length for the 197 patients was 5.9 ± 3.2 years for the operated knee and 5.5 ± 3.2 years for the nonoperated knee. A smaller postoperative JLCA in the operated knee was a significant risk factor for OA progression ( P = .027) and undergoing surgery ( P = .006) in the nonoperated knee. Conversely, a larger postoperative JLCA in the operated knee was a significant risk factor for OA progression ( P = .014) and conversion to arthroplasty ( P = .027) in the operated knee. A postoperative JLCA >1.5° ( P < .001) and <3.9° ( P < .001) was needed to reduce the risk of undergoing surgery in the nonoperated knee and OA progression in the operated knee, respectively. Additionally, a pre- to postoperative change in the JLCA (ΔJLCA) between −5.6° and −1.7° ( P = .021 and P = .004, respectively) was needed to reduce the risk of OA progression in both knees. Conclusion: A large medial joint opening (a small postoperative JLCA) in the operated knee after unilateral HTO was associated with a higher risk of OA progression and surgery in the nonoperated knee. Conversely, a small medial joint opening (a large postoperative JLCA) was associated with a higher risk of OA progression and conversion to arthroplasty in the operated knee. For a balanced medial joint opening, if the postoperative JLCA was between 1.5° and 3.9° or the ΔJLCA was between −5.6° and −1.7°, a favorable prognosis in both knees could be anticipated.