bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and management of growth hormone excess in patients with McCune–Albright syndrome
Authors: Yao Yong , Liu Yang , Wang Linjie , Deng Kan , Yang Hongbo , Lu Lin , Feng Feng , Xing Bing , You Hui , Jin Zimeng , Wang Renzhi , Pan Hui , Chen Shi , Zhu Huijuan 
Published: December 2016

Objective
McCune–Albright syndrome (MAS) is a sporadic, postzygotic disease presenting with fibrous dysplasia, cafe-au-lait spots and multiple endocrinopathies. Growth hormone (GH) excess is an uncommon but potentially severe complication of MAS. This study aims to describe the clinical manifestations of GH excess in the context of MAS and analyze the responses of these patients to treatments.

Design
Retrospective clinical study.

Methods
Clinical data from 52 MAS patients were analyzed. Serum GH and IGF1 levels, as well as nadir GH levels after an oral glucose tolerance test and alkaline phosphatase (ALP) levels were determined before and after the treatment.

Results
In total, 13 MAS patients (25%) had the complication of GH excess, including 10 males (76.9%). Among them, all had FD, and 6 patients had sphenoidal bone involvement. Visual deficits were present in 8 patients, and hearing deficits were present in 5. Olfactory dysfunction was observed in 3 patients. Evident pituitary adenomas were confirmed in 9 patients by MRI. These patients underwent surgery with or without pretreatment of long-acting somatostatin analogue octreotide, and 6 achieved complete remission. The serum ALP levels decreased significantly after treatment for GH excess.

Conclusions
MAS with GH excess is more common in male patients. GH excess can lead to more severe skeletal lesions in MAS patients involving more of the craniofacial bones. Complete trans-sphenoidal complete tumor excision with neuronavigational guidance is effective and could lower ALP levels. LAR is recommended as a preoperative treatment and when patients fail to achieve complete remission after surgery.
Genomic Trajectories to Desiccation Resistance: Convergence and Divergence Among Replicate Selected Drosophila Lines
Authors: Griffin Philippa C , Hangartner Sandra B , Fournier-Level Alexandre , Hoffmann Ary A 
Published: December 2016

Abstract
Adaptation to environmental stress is critical for long-term species persistence. With climate change and other anthropogenic stressors compounding natural selective pressures, understanding the nature of adaptation is as important as ever in evolutionary biology. In particular, the number of alternative molecular trajectories available for an organism to reach the same adaptive phenotype remains poorly understood. Here, we investigate this issue in a set of replicated Drosophila melanogaster lines selected for increased desiccation resistance—a classical physiological trait that has been closely linked to Drosophila species distributions. We used pooled whole-genome sequencing (Pool-Seq) to compare the genetic basis of their selection responses, using a matching set of replicated control lines for characterizing laboratory (lab-)adaptation, as well as the original base population. The ratio of effective population size to census size was high over the 21 generations of the experiment at 0.52–0.88 for all selected and control lines. While selected SNPs in replicates of the same treatment (desiccation-selection or lab-adaptation) tended to change frequency in the same direction, suggesting some commonality in the selection response, candidate SNP and gene lists often differed among replicates. Three of the five desiccation-selection replicates showed significant overlap at the gene and network level. All five replicates showed enrichment for ovary-expressed genes, suggesting maternal effects on the selected trait. Divergence between pairs of replicate lines for desiccation-candidate SNPs was greater than between pairs of control lines. This difference also far exceeded the divergence between pairs of replicate lines for neutral SNPs. Overall, while there was overlap in the direction of allele frequency changes and the network and functional categories affected by desiccation selection, replicates showed unique responses at all levels, likely reflecting hitchhiking effects, and highlighting the challenges in identifying candidate genes from these types of experiments when traits are likely to be polygenic.
Multiple Transcriptional and Post-transcriptional Pathways Collaborate to Control Sense and Antisense RNAs of Tf2 Retroelements in Fission Yeast
Authors: Mallet Pierre-Luc , Larochelle Marc , Bachand François 
Published: December 2016

Abstract
Retrotransposons are mobile genetic elements that colonize eukaryotic genomes by replicating through an RNA intermediate. As retrotransposons can move within the host genome, defense mechanisms have evolved to repress their potential mutagenic activities. In the fission yeast Schizosaccharomyces pombe, the mRNA of Tf2 long terminal repeat retrotransposons is targeted for degradation by the 3′–5′ exonucleolytic activity of the exosome-associated protein Rrp6. Here, we show that the nuclear poly(A)-binding protein Pab2 functions with Rrp6 to negatively control Tf2 mRNA accumulation. Furthermore, we found that Pab2/Rrp6-dependent RNA elimination functions redundantly to the transcriptional silencing mediated by the CENP-B homolog, Abp1, in the suppression of antisense Tf2 RNA accumulation. Interestingly, the absence of Pab2 attenuated the derepression of Tf2 transcription and the increased frequency of Tf2 mobilization caused by the deletion of abp1. Our data also reveal that the expression of antisense Tf2 transcripts is developmentally regulated and correlates with decreased levels of Tf2 mRNA. Our findings suggest that transcriptional and post-transcriptional pathways cooperate to control sense and antisense RNAs expressed from Tf2 retroelements.
О НОВОМ ИЗДАНИИ ПО РУССКОМУ ЯЗЫКУ КАК ИНОСТРАННОМУ
Authors: Мартемьянова Мария 
Published: December 2016

НЕКИПЕЛОВА, И. М., 2016. Шаг за шагом (русский язык как иностранный). Часть 1: Учебник [Текст]. Москва-Ижевск: Институт компьютерных исследований, НИЦ «Регулярная и хаотическая динамика». – 116 с.
Vascular flora of the Legado das Águas, Reserva Votorantim, municipalities of Tapiraí, Miracatú and Juquiá, São Paulo, Brazil
Authors: Colletta Gabriel Dalla , Souza Vinicius Castro , Almeida Thaís Elias , Cabral Fernanda Nunes , Diogo Ivan Jeferson , Flores Thiago Bevilacqua , Coelho Rubens Luiz Gayoso , Moreno Vanessa Souza , Salino Alexandre , Ferreira Marcelo Antonio Pinho , Ivanauskas Natália Macedo , Tamashiro Jorge Yoshio , Liboni Ana Paula , Neto Antonio Campos Rocha , Virillo Carolina Bernucci , Delfini Carolina Feliciano , Potascheff Carolina De Moraes , Braga Daniel Palma Perez , Oliveira Denise Balbão , Castillo-Díaz Diana Consuelo , Mello Felipe Nery , Florido Flávia Garcia , Fagundes Isabella Cruz , Rigon Jesiani , Kuntz Juliana , Costa Marina Fernanda Bortolin , Bettinardi Mariana Luiza , Oliveira Neto Mario Albino , Caramez Renata Bergamo , Polisel Rodrigo Trassi , Girão Vanessa Jó , Rodrigues Ricardo Ribeiro 
Published: December 2016

We present a list of vascular plants found in Legado das Águas, Reserva Votorantim, a private reserve having an area of approximately 35,000 ha that spans the municipalities of Tapiraí, Miracatú, and Juquiá, in the state of São Paulo, Brazil. The reserve is part of a complex of state-protected areas including Alto Ribeira Touristic State Park, Intervales State Park , Carlos Botelho State Park, Jurupará State Park, and Serra do Mar State Park. Together, these form an important and large area of continuous and well-preserved forest. Our study, which involved two main floristic surveys in March/April 2013 and April 2014, recorded 768 species, representing 131 families and 432 genera. The majority of species were angiosperms (619) representing 106 families and 370 genera. There were also two species of gymnosperms belonging to two genera in separate families; 147 species of ferns and lycophytes belonging to 23 families and 60 genera. In demonstrating the presence of almost 800 species of plants, of which 16 are threatened, our study highlights the importance of floristic surveys and the critical role of private protected areas in managing and preserving native flora.
GROWTH COMPARISON OF MAHSEER (Tor tambroides) FROM MANNA AND TARUSAN RIVER IN WESTERN SUMATERA RIVER
Authors: Wibowo Arif , Dwirastina Mirna 
Published: December 2016

Mahseer is commonly used as a premium consumption fish with exceptional price, however, these species have encountered dwindle in distribution and abudance. The objective of this study was to investigate and to compare aspects of the interspatial variability of Western Sumatra component growth of mahseer between Manna River and Tarusan River. Mahseer samples were collected from the Manna River, Bengkulu Province and Tarusan River, West Sumatra Province. Monthly sampling was carried out over a period of February to October 2012 in Manna River and February to July 2012 in Tarusan River for detailed growth study. A total of 295 mahseer samples were collected from five sampling sites in Manna River and 495 mahseer samples were collected from three sampling sites in Tarusan River. The results show the ge group population estimation of T. Tambroides from Manna River and Tarusan River based on the analysis of length-frequencies using the Bhattacharya method, resulted in two different age groups. The theoretical growth curve for length from Manna River, the values are L¥ = 50,45 cm, K = 1,90 yr-1, t0 = -0,07 yr-1 and F = 3,684, and for weight, the values are W¥ = 1395,49 gr, K = 0,71 yr-1, t0 = -0,078 yr-1 and F = 6,148. The parameters of the von Bertalanffy growth curve in length from Tarusan River were L¥ = 31,34 cm, K = 1,70 yr-1, t0 = -0,09 yr-1 and F = 3,21 and W¥ = 634,86 gr, K = 0,48 yr-1, t0 = -0,147 yr-1 and F = 5,282 in weight. The length-weight relationship estimated for Manna River was W = 0,000007TL3,086 for females (R2 = 0,9545, N = 91) and W = 0,0037TL1,882 for males. While for Tarusan River, length-weight relationship estimated was = 0,00003TL2,839. Mahseer from Manna River population has better growth parameters than those at Tarusan River.
THE SEASONAL VARIABILITY OF CPUE AND CATCH-AT-SIZE DISTRIBUTION OF TROLL AND HANDLINE TUNA FISHERIES LANDED IN LABUHAN LOMBOK
Authors: Setyadji Bram , Hartaty Hety , Mardlijah Siti 
Published: December 2016

Troll and hand line tuna fisheries is one of the major fishing gears landed in Labuhan Lombok coastal fishing port (PPP Labuhan Lombok) west Nusa Tenggara Barat province. Both fisheries are strongly associated with fish aggregating devices (FAD’s). The main fishing ground is Indian Ocean southern part of this province. Several source of data has been collected regularly. Data analysis comprised of monthlycatch and effort data samples based onport monitoring program during 2012 to 2015. The result showed the diclining of CPUE of yellow fin and skipjack tuna presumably related to fishing intensity of fleets and its variability that landed in PPP Labuhan Lombok. The increasing CPUE of skipjack tuna in 2014 was predicted due to increasing aggregation around the FADs. Constrasting seasonal fishing index pattern between yellowfin and skipjack tuna foundin 4-month cycles, started in January.A length-weight relationship suggested that yellowfin tuna caught bysmall-scale fisheries were performing allometric growth pattern (b=2.963, r2=0.9737).
La decoración caligráfica árabe y vegetal de las vigas del Museo Diocesano de Barcelona
Authors: Barceló Carmen , Labarta Ana 
Published: December 2016

Este artículo presenta y comenta la decoración de 13 vigas pintadas que proceden del Palacio Episcopal de Barcelona y se conservan en su Museo Diocesano. Estudia el texto que repite la jaculatoria al-mulk li-llāh en grafía árabe, su significado, el tipo de letra utilizado y el motivo-tipo y busca sus paralelos en diversas construcciones. Describe brevemente los otros elementos decorativos presentes en las vigas: vegetales, de lacería y escudos heráldicos. Su comparación con diferentes edificaciones de la Península Ibérica parece permitir datarlas hacia 1350. Los recortes y mutilaciones que se aprecian en ellas hacen suponer que tuvieron una primera ubicación, hoy ignota, y que en fecha desconocida fueron reutilizadas en la cubierta de la Sala de la Trinitat del Palacio Episcopal, donde aparecieron en 1981 durante las obras de remodelación de la techumbre.
Danza para los ojos azules / Dance for blue eyes
Authors: Vergara Ossa Yasna 
Published: December 2016

La danza de los ojos azules es producto de un proceso creativo llevado a cabo en el año 2014 por estudiantes de distintas generaciones de la Escuela de danza Espiral y la Universidad Academia de Humanismo Cristiano en Santiago de Chile. Su origen se arraiga en la visión cultural y espíritu artístico de sus fundadores, Patricio Bunster y Joan Turner, quienes en contexto político adverso en la Historia de Chile siguen una formación que pudiera recuperar, congregar y acercar la danza a sectores sin acceso al goce de este arte. Espiral contribuyó al restablecimiento de la tradición de extensión cultural en Chile, abriendo un espacio de desarrollo para el arte hacia diversos sectores sin imponer formas ni estilos, extendiendo la posibilidadde recuperación de la cultura artística a través de perspectivas de crecimiento, conocimiento e identidad.Dance for blue eyesThe blue eyes dance is a product of a creative process carried out in 2014 by students of different generations of the School of Dance Spiral and the University Academy of Christian Humanism in Santiago de Chile. Its origin is comes from the cultural vision and artistic spirit of its founders, Patricio Bunster and Joan Turner, who in an adverse political context in the history of Chile follow a formation to recover, congregate and bring dance to sectors without access to the artistic practice. Espiral contributed to the restoration of the tradition of cultural extension in Chile, opening a space for the development of art towards different sectors without imposing forms or styles, extending the possibility of recovery of the artistic culture through perspectives of growth, knowledge and identity.
El caracol como expresión del sonido, la fertilidad y su relación con el agua / The snail as an expression of sound, fertility and its relation to water.
Authors: Izquierdo Díaz Gerardo , Hernández Ramírez Giselda 
Published: December 2016

Los moluscos y sus conchas provenientes de los mares y cuencas fluviales, fueron aprovechados por el hombre desde hace milenios. Sus carnes formaban parte de su dieta. Testimonios de la actividad económica de recolección, han quedado como amontonamientos de ellas en diversas latitudes del planeta siempre en relación con espejos de agua. En ocasiones, en lugares muy remotos y alejados del mar, como sucede en Centroamérica. En este artículo damos cuenta de como es utilizado como referente en diversos contextos sociales, culturales y expresivos.The snail as an expression of sound, fertility and its relation to water.Mollusks and their shells from the seas and river basins have been used by humans for millennia. Their meats were part of their diet. Testimonies of the economic activity of collection, have remained as heaps of them in diverse latitudes of the planet always in relation to mirrors of water. Sometimes, in places very remote and far from the sea, as in Central America. In this article we realize how it is used as a reference in diverse social, cultural and expressive contexts.
Dibujar Música. Historia etnográfica en imágenes de una banda procesional / Investigating the accompanying pianist.
Authors: López Carmona Esther 
Published: December 2016

Este trabajo es el resultado de una investigación casi obsesiva por mi parte y de carácter etnográfico, se intenta explicar el significado de una banda procesional desde dentro, qué es de ella durante el año, qué pasa, cómo funciona… en definitiva, intento contar aquello que no se ve a simple vista en una procesión o un concierto. Todo esto no está contado de cualquier manera, lo cuento mediante ilustraciones y pequeñas anotaciones graficas, de forma que todo se entienda mejor y que el lector no se haga una interpretación distinta a la que yo quiero transmitir. Además aprovecho para unir dos disciplinas artísticas: la música y la pintura. Mediante los trazos doy significado a distintos aspectos musicales y a algo tan complejo como es una banda de música de Semana Santa, que además cuenta con gran numero connotaciones y significados propios.Investigating the accompanying pianist.Throughout the different epochs and educational systems, the pianists have been formed in the majority of the cases like interpreters, although almost all they end up working as piano teachers. Some few decide to opt for the specialty of Pedagogy of the Piano, a specialty oriented to the teaching. However, for the last years the most affordable work for young pianists who want to join the public system of education in our country is that of accompanying pianists. Although the number of pianists who perform this work increases each year according to the different lists of personnel placement, there is not currently in Spain a specialty focused on the preparation of accompanying futures. About this and other problems related to the practical exercise of the work and the lack of stability in their administrative situation complain the accompanying pianists in addition to the teachers and students of the different specialties of Music, Dance and Dramatic Art. However, despite the need to address all of this problem from a scientific perspective, the number of research carried out on this subject is very scarce in our country, so we believe that it will be very useful to compile a bibliography more relevant in this field of research. In the following article, articles, books and theses written both in Spain and abroad in relation to the figure and the work of accompanying pianists will be exposed and analyzed with brevity
The Unmaking of Roma Students: Contributing from a Critical and Engaged Ethnography
Authors: Baracsi Kitti 
Published: December 2016

In this study, the focus is put on the process by which the different educational actors – in this case mostly teachers – produce the image of Roma students and how a critical and engaged ethnography can show how ideas related to Roma culture, identity and integration play a role in the making of Roma students. Through this we can understand more thoroughly how the processes through which the categories that are meant to interpret the complexity of social processes or bring about positive changes become instruments that actually reinforce discriminative practices.
ANÁLISE DA MOTIVAÇÃO DOS DISCENTES DO CURSO DE CIÊNCIAS CONTÁBEIS E ADMINISTRAÇÃO, SOB A PERSPECTIVA DA TEORIA DA AUTODETERMINAÇÃO E DAS METAS DE REALIZAÇÃO
Authors: De Albuquerque Ediane Alves , Batista Fabiano Ferreira , Albuquerque Lúcia Silva , De Oliveira Francisco Daênnio Casimiro , Pereira Gianinni Martins 
Published: December 2016

<p>Cotidianamente a motivação é associada a desempenho, de tal modo que um indivíduo desmotivado apresentaria baixo desempenho. No entanto, a motivação apresenta-se como um processo psicológico associado à várias características de personalidade, como motivos, habilidades, interesses, expectativas, entre outras, o que impede tirar conclusões intuitivas a respeito do nível de motivação de um indivíduo sem o respaldo teórico. Dentre as teorias existentes e desenvolvidas para estudar os aspectos motivacionais, especificamente aqueles relacionados ao processo de aprendizagem, pode-se citar a Teoria da Autodeterminação e a Teoria das Metas de Realização que fundamentam esse estudo cujo objetivo é de investigar quais os tipos de motivação dos estudantes do curso de Ciências Contábeis e Administração da Universidade Federal de Campina Grande. Para tanto, utilizou-se de instrumentos desenvolvidos por pesquisadores relacionados a essas teorias e aplicou-se junto a 289 alunos com diferentes estágios de integralização do curso e, de posse do Coeficiente de Rendimento Acadêmico, avaliou-se a relação do tipo de motivação e desempenho. Os dados foram analisados a partir de estatística descritiva, teste T para diferença de Médias e Analise de Variância (ANOVA). Os resultados evidenciaram que os alunos encontram-se motivados tanto Extrinsecamente quanto Intrinsecamente, apresentando maior alinhamento com a motivação Intrínseca para Saber, seguida pela motivação Extrínseca Regulação-Externa, não sendo observadas diferenças significativas entre os cursos e nem relação evidente com o desempenho acadêmico ou com estágio de integralização do curso. </p>
AVALIAÇÃO DA QUALIDADE DA ÁGUA: DETERMINAÇÃO DOS POSSÍVEIS CONTAMINANTES DA ÁGUA DE POÇOS ARTESIANOS NA REGIÃO NOROESTE FLUMINENSE
Authors: Goudinho VITÓ Camila Vieira , Bernardo Ferreira da SILVA Luma Janayna , Lima OLIVEIRA Karoline De Moura , GOMES Anders Teixeira , De Oliveira NUNES Camila Ramos 
Published: December 2016

<p>A água é um recurso natural essencial para a vida na Terra. É considerado solvente universal pois consegue dissolver a maior parte das moléculas existentes. O Brasil é considerado uma das maiores reservas hídricas do mundo, porém, a água é um recurso limitado e com o passar dos anos vem se tornando mais escassa, resultado do uso irracional. Por ser de grande importância para o ser humano, ela precisa ser considerada potável para que possa ser consumida. O Conselho Nacional do Meio Ambiente (CONAMA) é o órgão responsável pela qualidade da água no Brasil. O consumo de águas subterrâneas é muitas vezes preferido por serem consideradas mais limpas quando comparadas às águas superficiais. Porém, dependendo do local onde o poço é perfurado, a água subterrânea pode acabar adquirindo contaminantes químicos e/ou biológicos originados de agrotóxicos, lixo, esgoto, dentre outros. No século XX, a região Noroeste Fluminense foi bastante utilizada para agricultura, com destaque para a produção de café. Atualmente, lavouras de café e tomate são predominante em algumas localidades. Os agrotóxicos utilizados nas plantações podem ser lixiviados pelo solo, contaminando a água dos lençóis freáticos. Nas zonas rurais, onde não se tem água encanada, é comum a utilização de poços rasos ou artesianos. Muitas vezes esses poços são perfurados perto dessas plantações, o que aumenta o risco de contaminação da água. Com o objetivo de verificar a qualidade da água de poços, muitas vezes destinados para o consumo, foram selecionados poços de áreas rurais da região Noroeste Fluminense para a realização de análises físico-química da água. Para determinação de íons possivelmente provenientes da contaminação por agrotóxicos, foi realizada análise em cromatógrafo de íons (IF Fluminense Polo de Inovação Campos dos Goytacazes). Os resultados obtidos foram confrontados com a legislação vigente para potabilidade.</p>