bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized Trial Comparing Classical Participatory Design to VandAID, an Interactive CrowdSourcing Platform to Facilitate User-centered Design
Authors: Dufendach Kevin R. , Koch Sabine , Unertl Kim M. , Lehmann Christoph U. 
Published: April 2017

Summary
Background: Early involvement of stakeholders in the design of medical software is particularly important due to the need to incorporate complex knowledge and actions associated with clinical work. Standard user-centered design methods include focus groups and participatory design sessions with individual stakeholders, which generally limit user involvement to a small number of individuals due to the significant time investments from designers and end users.
Objectives: The goal of this project was to reduce the effort for end users to participate in co-design of a software user interface by developing an interactive web-based crowd- sourcing platform.
Methods: In a randomized trial, we compared a new web-based crowdsourcing platform to standard participatory design sessions. We developed an interactive, modular platform that allows responsive remote customization and design feedback on a visual user interface based on user preferences. The responsive canvas is a dynamic HTML template that responds in real time to user preference selections. Upon completion, the design team can view the user’s interface creations through an administrator portal and download the structured selections through a REDCap interface.
Results: We have created a software platform that allows users to customize a user interface and see the results of that customization in real time, receiving immediate feedback on the impact of their design choices. Neonatal clinicians used the new platform to successfully design and customize a neonatal handoff tool. They received no specific instruction and yet were able to use the software easily and reported high usability.
Conclusions: VandAID, a new web-based crowdsourcing platform, can involve multiple users in user-centered design simultaneously and provides means of obtaining design feedback remotely. The software can provide design feedback at any stage in the design process, but it will be of greatest utility for specifying user requirements and evaluating iterative designs with multiple options.
Size Dependence of Dust Distribution around the Earth Orbit
Authors: Ueda Takahiro , Kobayashi Hiroshi , Takeuchi Taku , Ishihara Daisuke , Kondo Toru , Kaneda Hidehiro 
Published: April 2017

Abstract
In the solar system, interplanetary dust particles (IDPs) originating mainly from asteroid collisions and cometary activities drift to Earth orbit due to Poynting–Robertson drag. We analyzed the thermal emission from IDPs that was observed by the first Japanese infrared astronomical satellite, AKARI. The observed surface brightness in the trailing direction of the Earth orbit is 3.7% greater than that in the leading direction in the 9 μm band and 3.0% in the 18 μm band. In order to reveal dust properties causing leading–trailing surface brightness asymmetry, we numerically integrated orbits of the Sun, the Earth, and a dust particle as a restricted three-body problem including radiation from the Sun. The initial orbits of particles are determined according to the orbits of main-belt asteroids or Jupiter-family comets. Orbital trapping in mean motion resonances results in a significant leading–trailing asymmetry so that intermediate sized dust (∼10–100 μm) produces a greater asymmetry than zodiacal light. The leading–trailing surface brightness difference integrated over the size distribution of the asteroidal dust is obtained to be 27.7% and 25.3% in the 9 μm and 18 μm bands, respectively. In contrast, the brightness difference for cometary dust is calculated as 3.6% and 3.1% in the 9 μm and 18 μm bands, respectively, if the maximum dust radius is set to be s
max = 3000 μm. Taking into account these values and their errors, we conclude that the contribution of asteroidal dust to the zodiacal infrared emission is less than ∼10%, while cometary dust of the order of 1 mm mainly accounts for the zodiacal light in infrared.
A Search for Millisecond-pulsar Radio Emission from the Faint Quiescent Soft X-Ray Transient 1H 1905+000
Authors: Mikhailov K. , van Leeuwen J. , Jonker P. G. 
Published: April 2017

Abstract
Transitional millisecond pulsars (tMSPs) switch between an accretion-powered state without radio pulsations and a rotation-powered state with radio pulsations. In the former state, tMSPs are X-ray bright, while in the latter state, they are X-ray dim. Soft X-ray transients (SXTs) undergo similar switches in X-ray, between “high” states with bright X-ray outbursts and “low” states of quiescence. The upper limit on the quiescent X-ray luminosity of SXT 1H 1905+000 suggests that its luminosity might be similar to that of the known tMSPs. A detection of radio pulsations would link SXTs more strongly with tMSPs; and thus, e.g., put stricter constraints on tMSP transitional timescales through the connection with the well-known SXT periods of quiescence. A nondetection allows us, based on the telescope sensitivity, to estimate how likely these sources are to pulsate in radio. Over a 10-year span, 2006–2015, we carried out targeted radio observations at 400/800 MHz with Arecibo, and searched for radio pulsations from the quiescent SXT 1H 1905+000. None of the observations have revealed radio pulsations from the targeted SXT. For a 1 ms pulsar, our flux density upper limit is 10.3 μJy. At an assumed distance of 10 kpc this translates to a pseudo-luminosity upper limit of 1.0 mJy kpc2, which makes our search complete to ∼85% of the known MSP population. Given the high sensitivity, and the generally large beaming fraction of millisecond pulsars, we conclude that SXT 1H 1905+000 is unlikely to emit in radio as a tMSP.
Type Ib and IIb Supernova Progenitors in Interacting Binary Systems
Authors: Yoon Sung-Chul , Dessart Luc , Clocchiatti Alejandro 
Published: April 2017

Abstract
We explore properties of Type Ib and IIb SN progenitors that are produced by stable mass transfer in binary systems using a new grid of stellar evolution models from an initial primary mass in the range of

at solar and Large Magellanic Cloud metallicities. We find that blue and yellow supergiant SN IIb progenitors (e.g., of SN 2008ax, SN 2011dh, and SN 2016gkg) have a hydrogen envelope mass less than about

, mostly resulting from early Case B mass transfer with relatively low initial masses and/or low metallicity. Red supergiant (RSG) SN IIb progenitors (e.g., of SN 1993J, SN 2013df) are produced via late Case B mass transfers and have a more massive hydrogen envelope (

). SN Ib progenitors are predominantly produced by early Case B mass transfers. Our models predict that SN IIb progenitors are systematically more luminous in the optical (

) than the majority of SN Ib progenitors (

) for our considered initial mass range. However, the optically bright progenitor of SN Ib iPTF13bvn (i.e.,

) can be well explained by a relatively low-mass progenitor with a final mass of

. The event rate of blue and yellow SN IIb progenitors would increase as metallicity decreases, while the event rate of SN Ib progenitors would decrease instead. By contrast, the population of RSG SN IIb progenitors would not be significantly affected by metallicity.
Le folklore et l’ethnographie des Albanais (Albanie et Kosovo, 1945 ‑ 1991)
Authors: Halili Rigels , Muller Sylvie 
Published: April 2017

L’article esquisse le développement des études de folklore et d’ethnographie en Albanie et au Kosovo de 1945 à 1991. Cette période est celle des régimes communistes en Albanie et en Yougoslavie, dont le Kosovo fait alors partie. L’auteur révèle que le moteur du développement de ces disciplines n’est pas tant l’idéologie communiste que les idées nationales qui émergent au xix	e	siècle, pendant la période de formation de la nation albanaise.
Movement Matters: The Case of Southern Albania
Authors: Gregoric Bon Nastasa 
Published: April 2017

Cet article analyse les différents modes de mouvement et de sédentarité, de mobilité et d’immobilité qui fabriquent le sentiment de l’habité sur la côte méridionale de l’Albanie. Le mouvement ( kurbet ) et la sédentarité, telle qu’elle se manifeste dans la demeure ( shtëpi ) sont à la fois des institutions traditionnelles qui créent des réseaux d’enracinement au sein desquels les gens nouent des relations et des liens entre les différents lieux. Cependant on ne peut se contenter de lire les mobilités à la seule lueur des relations sociales et spatiales : il faut les lire aussi en référence aux caractéristiques géomorphologiques de la région. Au‑delà des peuples, des choses et des idées, les lieux se transforment aussi et changent de position, de sens et de valeur.
Price-Induced Changes in Greenhouse Gas Emissions from Agriculture, Forestry, and Other Land Use: A Spatial Panel Econometric Analysis
Authors: Chakir Raja , De Cara Stéphane , Vermont Bruno 
Published: April 2017

Cet article propose un éclairage quantitatif sur les effets des prix des intrants et des produits sur les émissions françaises de gaz à effet de serre du secteur des terres (agriculture, forêt et autres usages des sols) à une résolution départementale. Des modèles à effets aléatoires et à erreurs spatiales sont estimés sous forme réduite pour quatre catégories d’émissions : usage d’engrais azotés synthétiques, gestion des effluents d’élevage, fermentation entérique (sur la période 1990-2007), usages des sols incluant les changements d’usage et la forêt (sur la période 1992-2003). Les principaux résultats sont : 1) les effets des prix sur les émissions sont significatifs, bien que leur signe et leur ampleur varient selon la catégorie d’émissions, 2) les effets estimés apparaissent plus nettement lorsque les catégories d’émissions sont analysées séparément plutôt que de manière agrégée, et 3) la dimension spatiale joue un rôle important. Les modèles estimés sont utilisés pour simuler les effets d’un doublement des prix des cultures sur les émissions du secteur des terres. Les résultats indiquent une augmentation de 11 % des émissions agricoles.
Difficultés liées à l’autosoin chez les personnes vivant avec le diabète de type 2 : une revue de la littérature narrative basée sur le modèle d’Audulv, Asplund et Norbergh
Authors: Lafontaine Sarah , Ellefsen Édith 
Published: April 2017

Introduction : les activités d’autosoin exigent beaucoup d’adaptation chez les personnes vivant avec le diabète de type 2. Contexte : les interventions existantes pour soutenir l’autosoin sont souvent déterminées par une vision conventionnelle axée sur la gestion de la maladie. Objectif : cet article vise à présenter les difficultés des personnes vivant avec le diabète de type 2 selon le modèle d’intégration de l’autosoin d’Audulv, Asplund et Norbergh. Méthode : une revue de la littérature narrative sur l’autosoin chez les personnes adultes vivant avec le diabète de type 2 a été effectuée sur les banques de données CINAHL, MEDLINE, PsycINFO, PASCAL et FRANÇIS. Résultats : 29 articles ont été retenus. Les principales difficultés liées à l’autosoin sont répertoriées selon les quatre phases du modèle d’intégration de l’autosoin et les quatre facteurs liés au contexte de vie de la personne. Discussion : les infirmières auraient avantage à s’inspirer du modèle d’Audulv pour mieux comprendre les difficultés auxquelles les personnes sont confrontées afin de mieux intervenir auprès d’elles. Conclusion : d’autres études s’avèrent nécessaires afin de déterminer des stratégies permettant de soutenir les personnes selon chacune des difficultés identifiées.
Addition of Se affected concentration of Se in the second generation of Tartary buckwheat plants / Dodatek selena je vplival na koncentracijo Se v potomkah s Se obravnavanih rastlin
Authors: Golob Aleksandra , Gadžo Drena , Stibilj Vekoslava , Djikić Mirha , Gavrić Teofil , Germ Mateja 
Published: April 2017

Tartary buckwheat and common buckwheat plants were grown on the field in natural conditions at high elevation. Tartary buckwheat plants were foliarly treated with Se and S (126 μM for each element). Seeds were collected and sown to obtain the progeny of Se-and S- treated plants. Concentration of Se was measured in these plants. Concentration of Se in all plant parts was similar in control and S treated plants. The concentration of Se was the highest in plants from seeds grown on Se treated plants in roots and leaves. It is shown that Se treatments in previous generation affected Se concentration in the progeny of Tartary buckwheat. Results also showed that in untreated plants, Se concentration was higher in Tartary comparing to common buckwheat in roots and seeds. Key words: Tartary buckwheat, selenium, sulphur Navadna in tatarska ajda sta uspevali na njivi na visoki nadmorski višini. Tatarsko ajdo smo listno škropili s selenom in žveplom (126 μM za vsak element). Na koncu rastne sezone smo na rastlinah zbrali semena in jih naslednje leto posejali. Na ta način smo dobili potomce s Se in S obravnavanih rastlin. V teh rastlinah smo merili koncentracijo Se. Koncentracija Se pri tatarski ajdi je bila v vseh rastlinskih delih podobna pri kontrolnih rastlinah in rastlinah, zrastlih iz semen, obravanavanih s S. Najvišjo koncentracijo Se v listih in koreninah so imele rastline, zrasle iz semen, nabranih na rastlinah, listno škropljenih s Se. Rezultati kažejo, da se obravnavanje s Se v prvi generaciji izrazi v večji koncentraciji Se v potomkah teh rastlin pri tatarski ajdi. Izsledki raziskav so prav tako pokazali, da je koncentracija Se v kontrolnih rastlinah v koreninah in semenih višja pri tatarski ajdi v primerjavi z navadno ajdo. Ključne besede: tatarska ajda, selen, žveplo
Murinization and H Chain Isotype Matching of the Anti-GITR Antibody DTA-1 Reduces Immunogenicity-Mediated Anaphylaxis in C57BL/6 Mice
Authors: Belmar Nicole A. , Chan Sarah W. , Fox Melvin I. , Samayoa Josue A. , Stickler Marcia M. , Tran Ninian N. , Akamatsu Yoshiko , Hollenbaugh Diane , Harding Fiona A. , Alvarez Hamsell M. 
Published: April 2017

Abstract
Recent advances in immuno-oncology have shown that the immune system can be activated to induce long-term, durable antitumor responses. For immuno-oncology drug development, immune activation is often explored using rat Abs in immunocompetent mouse models. Although these models can be used to show efficacy, antidrug immune responses to experimental protein-based therapeutics can arise. Immunogenicity of surrogate Abs may therefore represent an important obstacle to the evaluation of the antitumor efficacy of immunomodulator Abs in syngeneic models. A recent publication has shown that anti-glucocorticoid–induced TNFR family–related protein agonistic Ab DTA-1 (rat or murinized IgG2a) can induce the development of anaphylaxis in C57BL/6 mice upon repeated i.p. dosing because of an anti-idiotypic anti-drug Ab immune response. This study was undertaken to address the impact of the immunogenicity derived from the Fc and variable domains. To this end, chimerized (rat V domains/mouse constant regions) and murinized (95% mouse sequence) DTA-1–based surrogate Abs with a murine IgG2c H chain isotype were created. Chimerization and murinization of DTA-1 did not affect receptor binding and glucocorticoid-induced TNFR family–related protein–induced T cell agonistic properties. Similar in vivo antitumor efficacy and intratumoral CD8+/regulatory T cells were also observed. Finally, treatment of C57BL/6 mice with the chimerized and murinized DTA-1 Abs on a C57BL/6-matched IgG2c isotype resulted in reduced development and severity of anaphylaxis as measured by decline of body temperature, behavioral effects, serum IL-4, IgE, and anti-drug Ab levels. These results suggest that careful murinization and selection of a strain-matched H chain isotype are critical to generate ideal surrogate Abs for testing immuno-oncology mechanisms in vivo.
Protection against osteoarthritis in experimental animals by nanogold conjugated snake venom protein toxin gold nanoparticle-Naja kaouthia cytotoxin 1
Authors: Gomes Antony , Saha Partha Pratim , Bhowmik Tanmoy , Dasgupta Anjan Kumar , Dasgupta Subir Chandra 
Published: April 2017

Background & objectives:
Increased severity of osteoarthritis (OA) and adverse side effects of its treatment led to the search for alternative therapies. It was previously reported that snake venom protein toxin Naja kaouthia cytotoxin 1 (NKCT1) and gold nanoparticle (GNP) individually have potential against excremental arthritis. In this study, we analyzed the protective activity of GNP conjugated protein toxin NKCT1 (GNP-NKCT1) against experimental OA.

Methods:
Gold nanoparticle conjugation with NKCT1 (GNP-NKCT1) was done and its physiochemical properties were studied. OA was induced in male albino rats by intra-articular injection of bacterial collagenase and treatment was done with NKCT1/GNP-NKCT1/standard drug (indomethacin). Physical parameter (ankle diameter), urinary markers (hydroxyproline, glucosamine, pyridinoline, deoxypyridinoline), serum and synovial membrane pro-inflammatory markers [tumour necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), IL-17, vascular endothelial growth factor (VEGF)] and matrix metalloproteinase 1 (MMP1) were measured. Joint histopathology and scanning electron microscopy imaging of articular cartilage surface were also done.

Results:
Physical parameters, urinary markers, serum and synovial membrane pro-inflammatory makers and MMP1 were increased in arthritic rats and significantly restored after GNP-NKCT1/NKCT1 treatment. Joint histopathology and scanning electron microscopy imaging of articular cartilage surface also indicated the protective effect of GNP-NKCT1 against inflammatory response and cartilage degradation in osteoarthritic rats.

Interpretation & conclusions:
In this study restoration of the arthritic markers and bone degradation by GNP-NKCT1 treatment indicated the anti-osteoarthritic property of GNP-NKCT1. Further studies need to be done to confirm these findings.
Echocardiographic abnormalities in cirrhosis & their correlation with severity of cirrhosis using Child-Pugh score among patients in a tertiary care hospital
Authors: Balde Jagruti , Rao N. Karthik , Ballala Kirthinath , Samanth Jyothi , Shetty K. Ranjan , Patil Navin , Avinash A. , Varghese George 
Published: April 2017

Background & objectives:
Child-Pugh score (CPS) is a widely used prognostic marker in cases of cirrhosis and pulmonary arterial hypertension (PAH). However, the role of this score in the quantification of severity of PAH is not well studied. In mild cases, echocardiography is more sensitive. This study was done to assess the association between echocardiography and severity of cirrhosis using CPS.

Methods:
A cross-sectional study was done from April to June 2014 in 42 patients with cirrhosis using a pre-tested semi-structured interview schedule.

Results:
There was no significant association between echocardiographic changes and CPS in patients with liver cirrhosis.

Interpretation & conclusions:
Advising an echocardiographic evaluation may prove beneficial in patients of Child-Pugh Grades B and C. However, more extensive studies are required to confirm the same.
Scrub typhus in Uttarakhand & adjoining Uttar Pradesh
Authors: Bhargava Anurag , Kaushik Reshma , Kaushik Rajeev Mohan , Sharma Anita , Ahmad Sohaib , Dhar Minakshi , Mittal Garima , Khanduri Sushant , Pant Priyannk , Kakkar Rajesh 
Published: April 2017

Background & objectives:
Scrub typhus is a re-emerging mite-borne rickettsiosis, which continues to be underdiagnosed, with lethal consequences. The present study was conducted to determine the seasonality, clinical presentation and predictors of mortality in patients with scrub typhus at a tertiary care teaching hospital in northern India.

Methods:
Scrub typhus was suspected in patients attending the hospital as per the standard case definition and serological evidence was obtained by performing an IgM ELISA.

Results:
A total of 284 patients with scrub typhus from urban and rural areas were seen, predominantly from July to November. The most common clinical presentation was a bilateral community-acquired pneumonia (CAP), which resembled pneumonia due to atypical pathogens and often progressed to acute respiratory distress syndrome (ARDS). An acute undifferentiated febrile illness (AUFI) or a febrile illness associated with altered sensorium, aseptic meningitis, shock, abdominal pain, gastrointestinal bleeding or jaundice was also seen. Eschars were seen in 17 per cent of patients, and thrombocytopenia, transaminitis and azotaemia were frequent. There were 24 deaths (8.5%) caused predominantly by ARDS and multi-organ dysfunction. The mortality in patients with ARDS was high (37%). ARDS [odds ratio (OR)=38.29, 95% confidence interval (CI): 9.93, 147.71] and acute kidney injury (OR=8.30, 95% CI: 2.21, 31.21) were the major predictors of death.

Interpretation & conclusions:
The present findings indicate that scrub typhus may be considered a cause of CAP, ARDS, AUFI or a febrile illness with multisystem involvement, in Uttarakhand and Uttar Pradesh, especially from July to November. Empiric therapy of CAP may include doxycycline or azithromycin to ensure coverage of underlying unsuspected scrub typhus.
Genetic polymorphisms of N-acetyltransferase 2 & susceptibility to antituberculosis drug-induced hepatotoxicity
Authors: Sharma Surendra K. , Jha Brajesh Kumar , Sharma Abhishek , Sreenivas V. , Upadhyay Vishwanath , Jaisinghani Chandrita , Singla Rohit , Mishra Hemant Kumar , Soneja Manish 
Published: April 2017

Background & objectives:
The N-acetyltransferase 2 (NAT2) gene encodes an enzyme which both activates and deactivates arylamine and other drugs and carcinogens. This study was aimed to investigate the role of NAT2 gene polymorphism in anti-tuberculosis drug-induced hepatotoxicity (DIH).

Methods:
In this prospective study, polymerase chain reaction-restriction fragment length polymorphism results for NAT2 gene were compared between 185 tuberculosis patients who did not develop DIH and 105 tuberculosis patients who developed DIH while on anti-tuberculosis drugs.

Results:
Frequency of slow-acetylator genotype was commonly encountered and was not significantly different between DIH (82.8%) and non-DIH (77.2%) patients. However, the genotypic distribution of variant NAT2*5/*7 amongst slow-acetylator genotypes was significantly higher in DIH (56%) group as compared to non-DIH (39%) group (odds ratio 2.02; P=0.006).

Interpretation & conclusions:
The present study demonstrated no association between NAT2 genotype and DIH in the north Indian patients with tuberculosis.
Space After Deleuze
Authors: Saldanha Arun 
Published: April 2017

Deleuze’s fondness for geography has long been recognized as central to his thought. This is the first book to introduce researchers to the breadth of his engagements with space, place and movement. Focusing on pressing global issues such as urbanization, war, migration, and climate change, Arun Saldanha presents a detailed Deleuzian rejoinder to a number of theoretical and political questions about globalization in a variety of disciplines. This systematic overview of moments in Deleuze’s corpus where space is implicitly or explicitly theorized shows why he can be called the 20th century’s most imaginative thinker of space.
Space After Deleuze is the first book to make clear to a student audience how Deleuze and thinkers close to him (Guattari, Foucault, Marx, Darwin) allow for a robust and politically engaged framework for studying spatial phenomena such as cities, nation-states, climate change, migration and map art. Anyone with an interest in refining a wide range of concepts, from territory, assemblage, to body, event, and the Anthropocene will learn much from the “geophilosophy” which Deleuze and Guattari proposed for our critical times.