bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Validation of Face‐Fit Surface‐Lighting Micro Light‐Emitting Diode Mask for Skin Anti‐Aging Treatment
Authors: Kim Min Seo , An Jaehun , Lee Jae Hee , Lee Seung Hyung , Min Seongwook , Kim Young Bin , Song Myoung , Park Sang Hyun , Nam Ki Yun , Park Hong Jin , Kim Ki Soo , Oh Sang Ho , Hahn Dongseon , Moon Jongsoo , Park June Whan , Park Jae Sung , Kim Taek‐Soo , Kim Beom Joon , Lee Keon Jae 
Published: October 2024

AbstractPhotobiomodulation therapy based on micro light‐emitting diodes (µLEDs) holds remarkable potential for the beauty industry. Here, a cosmetically effective face‐fit surface‐lighting µLED mask for skin anti‐aging is introduced. The face‐conformable mask enables deep tissue treatment through proximal light irradiation, with a 3D origami structure capable of adapting to complex facial contours with closed adherence. A blister‐assisted laser transfer achieves rapid and accurate µLEDs transfer at a high throughput of 50 chips per second, facilitating a mass‐producible and large‐area process. Finally, clinical trials demonstrate significant improvements in elasticity, sagging, and wrinkles across six facial areas, with a maximum enhancement of 340% in deep skin elasticity of the perioral area compared to the conventional LED mask group.
Synergistic Cationic Shielding and Anionic Chemistry of Potassium Hydrogen Phthalate for Ultrastable Zn─I2 Full Batteries
Authors: Fu Hao , Huang Shengyang , Wang Tian , Lu Jun , Xiong Peixun , Yao Kai , Byun Jin Suk , Li Wenwu , Kim Youngkwon , Park Ho Seok 
Published: October 2024

AbstractElectrolyte additives are investigated to resolve dendrite growth, hydrogen evolution reaction, and corrosion of Zn metal. In particular, the electrostatic shielding cationic strategy is considered an effective method to regulate deposition morphology. However, it is very difficult for such a simple cationic modification to avoid competitive hydrogen evolution reactions, corrosion, and interfacial pH fluctuations. Herein, multifunctional additives of potassium hydrogen phthalate (KHP) based on the synergistic design of cationic shielding and anionic chemistry for ultrastable Zn||I2 full batteries are demonstrated. K cations, acting as electrostatic shielding cations, constructed the smooth deposition morphology. HP anions can enter the first solvation shell of Zn2+ for the reduced activities of H2O, while they remain in the primary solvation shell and are finally involved in the formation of SEI, thus accelerating the charge transfer kinetics. Furthermore, by in situ monitoring the near‐surface pH of the Zn electrode, the KHP additives can effectively inhibit the accumulation of OH− and the formation of by‐products. Consequently, the symmetric cells achieve a high stripping–plating reversibility of over 4500 and 2600 h at 1.0 and 5 mA cm−2, respectively. The Zn||I2 full cells deliver an ultralong term stability of over 1400 cycles with a high‐capacity retention of 78.5%.
Solid‐State Revolution: Assessing the Potential of Solid Polymer Electrolytes in Lithium‐Ion Batteries
Authors: Hadad Saeed , Pope Michael A. , Kamkar Milad , Tam Kam Chiu 
Published: October 2024

AbstractLithium‐ion batteries (LIBs) are crucial for achieving sustainable energy goals due to their high energy density and long cycle life. They dominate markets like consumer electronics, electric vehicles, and stationary energy storage systems. However, current LIBs use liquid electrolytes, which are toxic, flammable, and their liquid state does not resist dendrite growth, causing battery capacity decline and failure. Additionally, the limited availability of lithium and other metals makes liquid‐based LIBs less sustainable. On the other hand, solid polymer electrolytes (SPEs) offer a safer alternative as they are non‐volatile and can resist dendrite growth. However, ion transport in solids is much more restricted than in liquids, while imperfect solid‐solid interfaces contribute to interfacial resistance leading to lower ionic conductivity and increasing Ohmic losses or requiring battery operation at elevated temperatures. Chemical and mechanical degradation of these interfaces can also result in battery capacity fade, and poorer cyclic performance compared to liquid electrolytes. Understanding the ionic transport mechanisms in SPEs is critical for designing and optimizing the nanostructure of polymers and polymer/electrode interfaces to overcome these limitations. In this review, the fundamental mechanisms of ion transport in SPEs will first be explored. Various state‐of‐the‐art approaches for addressing the key challenges in SPEs and their solutions are then discussed. Furthermore, the current status of SPEs is analyzed to determine their potential for replacing liquid electrolytes in the future.
Ordered PdBi Alloys for High‐Performance CO2 Electroreduction and Enhanced Formic Acid Selectivity
Authors: Liu Moxuan , Zhou Anning , Xu Zhongshuang , Jiang Yuhan , Zhang Lei , Fan Qikui 
Published: October 2024

AbstractElectrocatalytic conversion of CO2 to formic acid (HCOOH) represents a promising approach for storing renewable energy and addressing the challenges of hydrogen storage and transportation. Palladium (Pd) is the only known metal capable of achieving this process at nearly zero overpotential. However, its practical applications are severely limited by hydrogen evolution reaction (HER) competition and CO poisoning. Bimetallic alloys, especially intermetallics with ordered structures, offer an effective way to optimize performance due to their unique catalytic properties. Here, PdBi alloys are synthesized with ordered structures and adjustable ratios of active sites for efficient CO2 electroreduction to HCOOH. The o‐PdBi2 alloy effectively suppresses both HER competition and CO production during the CO2 reduction process, achieving ≈95% HCOOH selectivity across a wide range of current densities and excellent stability at industrial‐level current densities. Additionally, the ordered structure facilitates high selectivity maintenance while mitigating overpotential, resulting in a cell voltage of only 2.65 V at 200 mA cm−2. These findings provide a pathway for the practical application of Pd‐based catalysts in CO2 electroreduction.
Dynamic Coordination Engineering of Z‐Scheme (FFV)2PdCl2/C3N4 Heterojunction for Superior Photocatalytic Hydrogen Evolution
Authors: Xu Jiapeng , Liu Dong , Li Xinming , Zhang Xiaohu , Zhang Jing , Zhang Yuexing , Peng Tianyou 
Published: October 2024

AbstractRealizing highly efficient photocatalytic hydrogen evolution reaction (HER) is a key challenge. Herein, a (FFV)2PdCl2 complex is developed with dynamic coordination engineering between the PdII site and Fluoflavin (FFV) ligands, and couple it with graphite carbon nitride (g‐C3N4) ultrathin nanosheets to construct a novel Z‐scheme heterojunction ((FFV)2PdCl2/C3N4). The resultant heterojunction delivers a HER activity of 648 µmol h−1 under visible light (λ ≥ 400 nm) illumination and an apparent quantum yield up to 40.1% at 400 nm, far superior to those g‐C3N4‐based catalysts reported previously. Mechanistic and theoretical studies reveal that the dynamic coordination between the PdII site and FFV ligands not only significantly accelerates the electron transfer from g‐C3N4 to (FFV)2PdCl2 and then to the PdII sites via a Z‐scheme mechanism, but also effectively maintain the efficacy and stability of the PdII active sties, and thus the (FFV)2PdCl2/C3N4 with a ultralow Pd‐loading amount (ca. 0.1 wt.%) exhibits the impressive activity and durability. The present dynamic coordination and structural evolution of (FFV)2PdCl2 are also applicable for significantly improving the HER performance of other semiconductors, thus paving a potential way for manufacturing highly efficient and active H2 production systems.
Diatoms Inspired Green Janus Fabric for Efficient Fog Harvesting
Authors: Chen Yinjie , Ji Yating , Li Xiaoyan , Hou Keru , Cai Zaisheng 
Published: October 2024

AbstractFog harvesting is a promising path against the global freshwater scarcity. Asymmetric wettability fabric‐based fog collection materials inspired by the Namib desert beetle have been reported widely due to their easy access and adjustable structures. Nevertheless, the single drive force for water transportation produced by the asymmetric wettability is insufficient, causing a non‐ideal fog harvesting efficiency. Moreover, sustainability challenges persist for fog collection materials, primarily due to their heavy dependence on chemical treatments. Herein, a diatom‐inspired Janus fabric (Ly/Csp‐3) based on asymmetric wettability and aperture gradient is developed without additional physical or chemical treatment. The wettability gradient and aperture gradient generate dual directional drive forces that regulate the water transport direction more accurately and enhance the transportation rate more effectively. Ly/Csp‐3 reaches a one‐way transport index of 390.7% and a water collecting rate (WCR) of 1170.5 mg cm−2 h−1, while exhibiting the capability of anti‐acid rain and the resistance to sunlight. This work provides an efficient and programmable biomimetic design proposal for fibrous fog harvesting devices.
Rational Design of 3D Hierarchical Fe3S4 for Superior Sodium‐Ion Battery Anode Material
Authors: Gong Yuteng , Sun Yufeng , Li Yu , Wu Chuan , Bai Ying 
Published: October 2024

AbstractAmong various transition metal sulfides, iron‐based sulfides have attracted wide attention due to their abundant resources, low cost, and non‐toxicity, showing considerable research value in the field of secondary batteries. Thereinto, Fe3S4 has a high theoretical specific capacity of 785 mAh g−1. However, at present, the research related to Fe3S4 anode for sodium‐ion batteries (SIBs) is still in its infancy, and it also suffers from severe volume expansion and limited preparation. Therefore, to further boost its sodium storage potential, the Fe3S4@rGO composite with hierarchical structure and carbonaceous network is proposed in this study. Beneficial from the ingenious hierarchitectures and flexible graphene coating, the Fe3S4@rGO anode exhibits outstanding sodium storage performance, which can deliver a high capacity of 603 mAh g−1 after 1500 cycles with a superior capacity retention of 98%. The micron flower‐like structure composed of 2D nanosheets can provide sufficient active sites and promote the rapid transport of Na+. Meanwhile, the 3D interconnected graphene carbon network makes a crucial contribution to alleviating volume changes and enhancing electrical conductivity. This work reveals the application potential of Fe3S4 as an anode electrode for SIBs and provides available insights for the development of other electrode materials.
An Overview of the Cancer Targeting Attributes of the Elastin Like Polypeptide Nano‐Carriers: Discerning Active and Passive Modes
Authors: Goel Ridhima , Gulwani Deepak , Upadhyay Priyanka , Sarangthem Vijaya , Singh Thoudam Debraj 
Published: October 2024

AbstractSince the 1940s, generalized cytotoxic therapy has been a valuable tool in cancer treatment. Over the years, there's been a significant increase in developing potential cytotoxic drugs. However, little progress has been made in enhancing patients' quality of life. The therapeutic index is limited due to the drug's poor solubility and lack of selectivity. Various carriers have been explored for drug delivery to enhance efficacy. Yet, there's a gap for a versatile delivery system that can adjust to specific drug and application requirements. Here, a multifaceted drug delivery platform based on a genetically engineered nature‐inspired polymer, elastin‐like polypeptide (ELP) is introduced. This technology enables the customization of the polymeric vehicle's physicochemical characteristics to suit the needs of a specific drug and application. The review highlights ELP's advantages in cancer targeting, such as site‐specificity, controlled release, biocompatibility, and extended plasma circulation. For the first time, ELP‐based drug delivery into passive and active targeting for better comprehension of its adaptability is classified. Moreover, numerous opportunities for loading different types of drugs onto the polymer are outlined. Finally, the polymer's efficacy in delivery across multiple cancer types, underscoring the wide spectrum of ELP‐based cancer drug delivery is precisely described.
ROS‐Activatable Prodrug of Doxazolidine as Novel Cancer Therapy Paradigm
Authors: Tamura Ryo , Carpenter Chace I. , Thomas Charlotte M. , Kamyabi Ghazal , Hsu Hsiao‐Ting , Vergnolle Olivia , Balderes Paul , Grimm Jan 
Published: October 2024

AbstractOvercoming severe side effects from anticancer agents without decreasing their effects on tumor growth is a major challenge. A prodrug technology is reported using agents that are spatiotemporally activated primarily in tumors while the extratumoral toxicity to healthy cells is minimized. A ROS‐activatable prodrug of a strong anticancer agent, doxazolidine (doxaz), is developed. Doxaz is a DNA alkylating agent with a half‐life of 3 min and significantly higher cytotoxicity than the clinically used parental compound doxorubicin (dox). Importantly, doxaz is not affected by p‐glycoprotein expression since it irreversibly alkylates DNA while dox inhibits the topoisomerase II DNA complex. As drug activators, reactive oxygen species (ROS) are already produced inside cancer cells in higher abundance than in normal cells but additionally generated by external stimuli such as radionuclides (via radiolysis of water) and/or ROS‐inducing drugs. We synthesized the prodrug, Doxaz‐BA, and evaluated its efficacy in vitro in cell cultures and then in vivo in xenograft mouse models. Doxaz‐BA is effective in a broad range of cancer cells since most cancer cells produce higher levels of ROS. Combining with clinically relevant radiotracers such as 18F‐FDG or other tumor‐tropic agents / ROS inducing drugs results in a tumor‐specific and enhanced localized therapy paradigm.
Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage‐Mediated Mitotic Catastrophe
Authors: Peng Shengjie , Feng Yue , Yu K.N. , Wu Lijun , Chen Guodong , Yang Miaomiao , Zhao Lele , Cao Wei , Cui Qianwen , Chen Lianjun , Li Quan , Huang Yifan , Cheng Cheng , Zhu Fengqin , Han Wei 
Published: October 2024

AbstractDespite the promise of cold atmospheric plasma (CAP) for cancer treatment, the challenges associated with the treatment of solid tumors and penetration depth limitations remain, restricting its clinical application. Here, biological evidence is provided that the killing effect of CAP treatment is confined to less than 500 µm subcutaneously and the actual biological dose decreased gradually with depth for the first time, indicating that the limited penetration depth has become an urgent problem that demands immediate solutions. Significantly, it is showed that different from high‐dose treatments, CAP decreased the doses to the low‐dose range but still exhibited anti‐tumor effects via mitotic catastrophe. Unlike radiotherapy or chemotherapy, low‐dose CAP treatment induces mitochondrial structural damage and dysfunction, disrupts energy metabolism and redox balance, and results in mitotic catastrophe. Collectively, these findings suggest that better understanding and taking full advantage of the dose‐response gradient effect of CAP is a potential strategy to prompt its clinical application beyond improving CAP penetration.
A Tympanic Piezo‐Bioreactor Modulates Ion Channel‐Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon‐Derived Cells.
Authors: Fernandez‐Yague Marc A. , Palma Matteo , Tofail Syed A. M. , Duffy Maeve , Quinlan Leo R. , Dalby Mathew J. , Pandit Abhay , Biggs Manus J. 
Published: October 2024

AbstractPreserving the function of human tendon‐derived cells (hTDCs) during cell expansion is a significant challenge in regenerative medicine. In this study, a non‐genetic approach is introduced to control the differentiation of hTDCs using a newly developed tympanic bioreactor. The system mimics the functionality of the human tympanic membrane, employing a piezoelectrically tuned acoustic diaphragm made of polyvinylidene fluoride‐co‐trifluoroethylene and boron nitride nanotubes. The diaphragm is vibrationally actuated to deliver targeted electromechanical stimulation to hTDCs. The results demonstrate that the system effectively maintains the tendon‐specific phenotype of hTDCs, even under conditions that typically induce nonspecific differentiation, such as osteogenesis. This stabilization is achieved by modulating integrin‐mediated mechanosignaling via ion channel‐regulated calcium activity, potentially by TREK‐1 and PIEZO1, yet targeted studies are required for confirmation. Finally, the system sustains the activation of key differentiation pathways (bone morphogenetic protein, BMP) while downregulating osteogenesis‐associated (mitogen‐ctivated protein kinase, MAPK and wingless integrated, WNT) pathways and upregulating Focal Adhesion Kinase (FAK) signaling. This approach offers a finely tunable, dose‐dependent control over hTDC differentiation, presenting significant potential for non‐genetic approaches in cell therapy, tendon tissue engineering, and the regeneration of other mechanosensitive tissues.
Ferroelectric Smectic C Liquid Crystal Phase with Spontaneous Polarization in the Direction of the Director
Authors: Kikuchi Hirotsugu , Nishikawa Hiroya , Matsukizono Hiroyuki , Iino Shunpei , Sugiyama Takeharu , Ishioka Toshio , Okumura Yasushi 
Published: October 2024

AbstractIn the previous study, the existence of an unidentified ferroelectric smectic phase is demonstrated in the low‐temperature region of the ferroelectric smectic A phase, where the layer spacing decreases with decreasing temperature. In the present study, the phase is identified by taking 2D X‐ray diffraction images of a magnetically oriented sample while allowing it to rotate and constructed a 3D reciprocal space with the sample rotation angle as the third axis for the whole picture of the reciprocal lattice vectors originating from the smectic structure. Consequently, circular diffraction images are obtained when the reciprocal lattice vectors are evenly distributed on the conical surface at a certain inclination angle in the reciprocal space. This result provides clear evidence that the phase in question is smectic C. The polarization properties also showed that the observed smectic C phase has spontaneous polarization in the direction parallel to the director and is identified as ferroelectric smectic C. These results provide a new type of classification for liquid crystalline phases that has been established over many years and is a significant contribution to the basic science of soft matter research.
Nitrous oxide emissions and yields from potato production systems as influenced by nitrogen fertilization and irrigation: A meta‐analysis
Authors: Ball Matt , Hernandez‐Ramirez Guillermo 
Published: October 2024

AbstractPotato (Solanum tuberosom) is a globally significant crop in relation to the scale of its consumption, being the third most consumed worldwide. The overall sustainability of global agriculture is increasingly of concern, specifically in relation to increasing anthropogenic emissions of the greenhouse gas nitrous oxide (N2O) emissions from nitrogen fertilizer additions to croplands and its contribution to climate change. Against this backdrop, a meta‐analysis of 119 experimental comparisons from 18 studies—spanning 19 study sites in 10 countries—was employed to investigate the impact of irrigation, cumulative water input, N fertilizer application rate, soil pH, and soil texture on cumulative N2O fluxes and tuber yield in potato production. Compared to non‐fertilized controls, N2O emissions from fertilized potato production decreased by 34% when irrigation provided 61%–90% of total water input (corresponding to averages of 321–473 mm). Likewise, N2O emissions increased by 53% with 200–475 mm seasonal water input and by 37% with N fertilization rates of 101–200 kg N fertilizer ha−1. Furthermore, soil pH between 7.1 and 7.5 reduced emissions by 6%, while medium‐textured soils showed an increase of 2%. Conversely, tuber yields from fertilized potato production were comparatively maximized under 31%–60% of water input as irrigation (7%) and 751–1025 mm cumulative seasonal water input (28%). Alongside 201–300 kg N fertilizer ha−1 (97%), soil pH of 7.1–7.5 (48%), and in coarse‐textured soils (49%). Overall, these findings underscore the importance of considering irrigation and N fertilization options specifically in optimizing potato production for reduced N2O emissions and enhanced tuber yield.
Acid Sensors Based on Luminochromism of Solid‐State Excimer Emission of Pyrene‐Modified Polyhedral Oligomeric Silsesquioxane
Authors: Narikiyo Hayato , Gon Masayuki , Tanaka Kazuo , Chujo Yoshiki 
Published: October 2024

AbstractTo obtain solid‐state fluorescence sensors, it is essential to simultaneously obtain solid‐state emission and stimuli‐responsiveness. In this research, the modified polyhedral oligomeric silsesquioxane (POSS) tethered with pyrenes was synthesized and we confirmed that both demands for developing solid‐state fluorescence sensors can be satisfied. The POSS derivative exhibited strong emission even in the solid state. In particular, we found that exposure of the POSS films to trifluoroacetic acid vapor resulted in a significant red‐shift of the peak wavelength of the emission band. Excitation spectroscopy and comparison with model compounds suggest that this significant red‐shift should be attributable to the formation of static excimer, meaning a preformed dimer in the ground state induced by protonation of the secondary amino groups. These results indicate that POSS is a promising scaffold for a solid‐state fluorescence sensor.
The Alzheimer's Disease Neuroimaging Initiative‐4 (ADNI‐4) Engagement Core: A culturally informed, community‐engaged research (CI‐CER) model to advance brain health equity
Authors: Rivera Mindt Mónica , Arentoft Alyssa , Calcetas Amanda T. , Guzman Vanessa A. , Amaza Hannatu , Ajayi Adeyinka , Ashford Miriam T. , Ayo Omobolanle , Barnes Lisa L. , Camuy Alicia , Conti Catherine , Diaz Adam , Easter Bashir , Gonzalez David J. , Dotson Yolanda Graham , Hoang Isabella , Germano Kaori Kubo , Maestre Gladys E. , Magaña Fabiola , Meyer Oanh L. , Miller Melanie J. , Nosheny Rachel , Park Van M. Ta , Parkins Shaniya , Thomas Lisa Renier , Strong Joe , Talavera Sandra , Verney Steven P. , Weisensel Trinity , Weiner Michael W. , Okonkwo Ozioma C. ,   the Alzheimer's Disease Neuroimaging Initiative
Published: October 2024

AbstractINTRODUCTIONThe Alzheimer's Disease Neuroimaging Initiative‐4 (ADNI‐4) Engagement Core was launched to advance Alzheimer's disease (AD) and AD‐related dementia (ADRD) health equity research in underrepresented populations (URPs). We describe our evidence‐based, scalable culturally informed, community‐engaged research (CI‐CER) model and demonstrate its preliminary success in increasing URP enrollment.METHODSURPs include ethnoculturally minoritized, lower education (≤ 12 years), and rural populations. The CI‐CER model includes: (1) culturally informed methodology (e.g., less restrictive inclusion/exclusion criteria, sociocultural measures, financial compensation, results disclosure, Spanish Language Capacity Workgroup) and (2) inclusive engagement methods (e.g., the Engagement Core team; Hub Sites; Community–Science Partnership Board).RESULTSAs of April 2024, 60% of ADNI‐4 new in‐clinic enrollees were from ethnoculturally or educationally URPs. This exceeds ADNI‐4's ≥ 50% URP representation goal for new enrollees but may not represent final enrollment.DISCUSSIONFindings show a CI‐CER model increases URP enrollment in AD/ADRD clinical research and has important implications for clinical trials to advance health equity.Highlights
The Alzheimer's Disease Neuroimaging Initiative‐4 (ADNI‐4) uses a culturally informed, community‐engaged research (CI‐CER) approach.
The CI‐CER approach is scalable and sustainable for broad, multisite implementation.
ADNI‐4 is currently exceeding its inclusion goals for underrepresented populations.