bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEFINING RELATIONAL PATHOLOGY IN EARLY CHILDHOOD: THE DIAGNOSTIC CLASSIFICATION OF MENTAL HEALTH AND DEVELOPMENTAL DISORDERS OF INFANCY AND EARLY CHILDHOOD DC:0–5 APPROACH
Authors: Zeanah Charles H. , Lieberman Alicia 
Published: August 2016

ABSTRACTInfant mental health is explicitly relational in its focus, and therefore a diagnostic classification system for early childhood disorders should include attention not only to within‐the‐child psychopathology but also between child and caregiver psychopathology. In this article, we begin by providing a review of previous efforts to introduce this approach that date back more than 30 years. Next, we introduce changes proposed in the Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood DC:0–5 (ZERO TO THREE, in press). In a major change from previous attempts, the DC:0–5 includes an Axis I “Relationship Specific Disorder of Early Childhood.” This disorder intends to capture disordered behavior that is limited to one caregiver relationship rather than cross contextually. An axial characterization is continued from the Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood DC:0–3R (ZERO TO THREE, 2005), but two major changes are introduced. First, the DC:0–5 proposes to simplify ratings of relationship adaptation/maladaptation, and to expand what is rated so that in addition to characterizing the child's relationship with his or her primary caregiver, there also is a characterization of the network of family relationships in which the child develops. This includes coparenting relationships and the entire network of close relationships that impinge on the young child's development and adaptation.
Work Ethic, Social Ethic, no Ethic: Measuring the Economic Values of Modern Christians
Authors: Colvin Christopher L. , McCracken Matthew 
Published: August 2016

SummaryBenito Arruñada finds evidence of a distinct Protestant social ethic in the ISSP's 1998 Religion II Survey (Economic Journal 2010; 120: 890–918). We replicate Arruñada's results using his broad definition of Protestantism and our new narrow definition, which includes only those ascetic denominations that Max Weber singled out for possessing a strong capitalist work ethic. We then extend this analysis to the ISSP's 2008 Religion III Survey, the most recent comparable international questionnaire on religious attitudes and religious change. We find no evidence of a Calvinist work ethic, and suggest that Arruñada's Protestant social ethic continues into the 21st century. Copyright © 2016 John Wiley & Sons, Ltd.
Upper airway stimulation therapy: A novel approach to managing obstructive sleep apnea
Authors: Soose Ryan J. , Gillespie M. Boyd 
Published: August 2016

ObjectivesReview the role of upper airway stimulation (UAS) therapy in the management of moderate to severe obstructive sleep apnea (OSA).Data SourcesA literature search was performed of PubMed and Medline using the search terms clinical trial; obstructive sleep apnea; upper airway stimulation; hypoglossal stimulation; hypoglossal nerve; Inspire; and ImThera.Review MethodsAll published clinical trials of currently available devices were reviewed. Unpublished data were excluded.ResultsUAS therapy results in surgical success (AHI decrease of >50% and overall AHI <= 20) in 66% of implanted subjects. In addition, UAS therapy results in significant improvement in daytime sleepiness, snoring, and sleep‐related quality of life.ConclusionUAS therapy is a valid alternative for select patients with moderate to severe OSA who are unsuccessful users of CPAP therapy. Laryngoscope, 126:S5–S8, 2016
Improving writing processes using lean and Kanban
Authors: Bass Julian M. 
Published: August 2016

Key points
Concepts from lean manufacturing and Kanban production can usefully be applied to writing for academic publication.
Value and pull focus the author's attention on the needs of reviewers, editors, and readers.
Value stream and flow emphasize an end‐to‐end process of prioritization, writing, editing, revision, resubmission, and publication
Perfection places emphasis on publication quality.
A Kanban board is advocated to plan and monitor the writing and publication lifecycle.
The author's experience shows a steady improvement in output rankings and researcher reputation metrics over a four‐year period.
A Fuzzy Topsis Method for Prioritized Aggregation in Multi‐Criteria Decision Making Problems
Authors: Fayek Aminah Robinson , Omar Moataz Nabil 
Published: August 2016

AbstractAggregation in a decision making environment requires the fusion of opinions of a group of decision makers. The group of decision makers are required to analyse a set of interrelated criteria that are usually measured on a linguistic scale. This process requires, in many instances, to capture experts experience, intuition and thinking that are traditionally expressed in a linguistic fashion rather than a numerical fashion. Furthermore, the necessity of considering the relationship between the criteria to the overall decision must be considered by the group of decision makers. This paper extends the application of fuzzy numbers, fuzzy relative importance scores (FRIS), fuzzy relative weights (FRW) and the fuzzy technique of order preference by similarity to ideal solution (TOPSIS) in prioritized aggregation. This extension provides a mean to systematically aggregate a group of decision makers' views for a set of interrelated criteria that are measured on a linguistic scale. First, an overview of the application of fuzzy numbers and the characteristics of aggregating fuzzy numbers in multi‐criteria decision making problems are presented. Then, the application of TOPSIS in fuzzy environments is presented. Next, past research is highlighted to present prioritized aggregation and the different aggregation operators' classes. Subsequently, a new prioritized aggregation method is presented. This method utilizes fuzzy TOPSIS with prioritized aggregation in fuzzy environments. Finally, the fuzzy prioritized aggregation method presented in this paper is applied on an actual case study. According to the results, the method presented in this paper provides a systematic approach to capture the uncertainty and imprecision associated with quantifying linguistic measurements in multi‐criteria decision making problems. Furthermore, it considers the relationship between the set of linguistically measured criteria undergoing prioritized aggregation in a fuzzy environment. Lastly, findings, conclusions and future work are presented. Copyright © 2016 John Wiley & Sons, Ltd.
Hierarchical Analysis of Bioactive Matched Molecular Pairs, Encoded Chemical Transformations, and Associated Substructures
Authors: Hu Ye , Bajorath Jürgen 
Published: August 2016

AbstractThe matched molecular pair (MMP) concept has become popular to assess molecular property changes resulting from small chemical modifications and study structure‐activity relationships (SARs). In this study, we further extend MMP analysis by introducing an MMP‐based hierarchical analysis scheme. Specifically, we report a large‐scale analysis of MMPs derived from bioactive compounds following a defined “MMP‐transformation‐substructure” hierarchy. This makes it also possible to categorize transformations and corresponding substructures on the basis of activity information. MMPs were systematically generated for compounds active against current pharmaceutical targets and stepwise decomposed into transformations and substructures. Surprisingly, most chemical transformations were only associated with single MMPs. Hence, the structural context of transformations was unexpectedly narrow. In addition, nearly half of all substructures were found to exclusively form single‐target transformations. Taken together, the results of our analysis provide a detailed view of MMP‐transformation‐substructure hierarchy and further increase the knowledge base of the MMP approach.
Preliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2
Authors: Naumczuk Beata , Kawęcki Robert , Bocian Wojciech , Bednarek Elżbieta , Sitkowski Jerzy , Kozerski Lech 
Published: August 2016

AbstractThe synthesis of water‐soluble SN38 derivatives is presented, and their stability in solutions used during drug development studies has been investigated. A preliminary study of mechanism of action of 9‐aminomethyl SN38 is presented. Using NMR techniques, the interaction of the oligomer d(GCGATCGC)2 is studied, showing that the terminal GC base pairs are the main site of interaction. Using pulsed field gradient spin echo and mass spectroscopy, evidence of a spontaneous alkylation reaction of the DNA oligomer with SN38 derivatives is presented. A proposed mechanism of reaction is suggested. Copyright © 2016 John Wiley & Sons, Ltd.
Mehrere Schimmelpilzgifte mit einer Methode
Authors: Stenzler Jan 
Published: August 2016

AbstractMykotoxine entstehen als Stoffwechselprodukte von Schimmelpilzen, die pflanzliche Lebensmittel auf dem Feld und während der Lagerung befallen. Wegen ihrer toxischen und krebserregenden Eigenschaften gelten weltweit niedrige Höchstgehalte. LC‐MS/MS erreicht die Bestimmungsgrenzen und erfasst viele Mykotoxine auf einmal.
Neue Bausteine für die organische Elektronik
Authors: Mai Juri , Orthaber Andreas 
Published: August 2016

AbstractPhosphoratome in π‐konjugierten Systemen beeinflussen deren elektronische Eigenschaften. Die entstehenden ungesättigten und niedervalenten Organophosphorverbindungen eignen sich beispielsweise für Schalter, elektrochrome Materialien und Photovoltaik.
An adaptive simplex cut‐cell method for high‐order discontinuous Galerkin discretizations of conjugate heat transfer problems
Authors: Ojeda Steven M. , Sun Huafei , Allmaras Steven R. , Darmofal David L. 
Published: August 2016

SummaryIn this paper, we present a solution framework for high‐order discretizations of conjugate heat transfer problems on non‐body‐conforming meshes. The framework consists of and leverages recent developments in discontinuous Galerkin discretization, simplex cut‐cell techniques, and anisotropic output‐based adaptation. With the cut‐cell technique, the mesh generation process is completely decoupled from the interface definitions. In addition, the adaptive scheme combined with the discontinuous Galerkin discretization automatically adjusts the mesh in each sub‐domain and achieves high‐order accuracy in outputs of interest. We demonstrate the solution framework through several multi‐domained conjugate heat transfer problems consisting of laminar and turbulent flows, curved geometry, and highly coupled heat transfer regions. The combination of these attributes yield nonintuitive coupled interactions between fluid and solid domains, which can be difficult to capture with user‐generated meshes. Copyright © 2016 John Wiley & Sons, Ltd.
Decreased fetal hemoglobin over time among youth with sickle cell disease on hydroxyurea is associated with higher urgent hospital use
Authors: Green Nancy S. , Manwani Deepa , Qureshi Mahvish , Ireland Karen , Sinha Arpan , Smaldone Arlene M. 
Published: August 2016

AbstractBackgroundHydroxyurea (HU) induces dose‐dependent increased fetal hemoglobin (HbF) for sickle cell disease (SCD). Large deviation from historical personal best (PBest) HbF, a clinic‐based version of maximum dose, may identify a subset with suboptimal HU adherence over time.ProcedureRetrospective clinical data from youth ages 10–18 years prescribed HU at two centers were extracted from medical records at three time points: pre‐HU initiation, PBest and a recent assessment. Decrease from PBest HbF of 20% or more at recent assessment despite stable dosing was designated as high deviation from PBest. Acute hospital use was compared between 1‐year periods, pre‐HU and ±6 months for PBest and recent assessment. Groups were compared using descriptive and bivariate nonparametric statistics.ResultsSeventy‐five youth, mean HU duration 5.9 years, met eligibility criteria. Mean ages of HU initiation, PBest and recent assessment were 8.0, 10.9 and 13.9 years, respectively. Despite stable dosing, average HbF of 19.5% at PBest overall declined by 31.8% at recent assessment. PBest HbF declined by 11.7 and 40.1% in two groups, the latter comprised 70.7% of the sample, had lower pre‐HU and recent HbF and higher dosing. They experienced more urgent hospital use during the year framing recent assessment than during PBest; these findings were supported by sensitivity analysis.ConclusionsDecline from PBest HbF is a novel approach to assess HU effectiveness, is common among youth and may represent suboptimal adherence. Larger prospective studies using additional adherence measures are needed to confirm our approach of tracking HbF deviation over time and to define an appropriate cutoff.
Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease
Authors: Horst Jennifer , Frei‐Jones Melissa , Deych Elena , Shannon William , Kharasch Evan D. 
Published: August 2016

AbstractBackgroundVaso‐occlusive episodes (VOEs) are a significant source of morbidity among children and adults with sickle cell disease (SCD). There is little information on methadone use for SCD pain. This investigation evaluated methadone pharmacokinetics in children and adults with SCD, with a secondary aim to assess pain relief and opioid consumption.ProcedureParticipants included children (<18 years) and adults with a VOE requiring hospitalization. Patients were randomly assigned to receive standard care (opioid patient‐controlled analgesia; control group) or one dose of intravenous methadone (0.1–0.125 mg/kg) in addition to standard care (methadone group). Venous methadone and metabolite concentrations were measured. Pain scores, pain relief scores, and opioid consumption were recorded.ResultsTwenty‐four children (12 methadone, 12 controls) and 23 adults (11 methadone, 12 controls) were studied. In children, the half‐life of R‐ and S‐methadone enantiomers was 34 ± 16 and 24 ± 9 hr, respectively. In adults, R‐ and S‐methadone half‐lives were 52 ± 17 and 38 ± 12 hr, respectively. Pain scores were lower (P = 0.002) and pain relief scores were higher (P = 0.0396) in children receiving methadone versus controls. There was no difference in pain scores and pain relief in adults receiving methadone versus controls. There was no difference in opioid consumption between methadone and control groups, in both adults and children.ConclusionsIntravenous methadone disposition in children and adults with SCD was comparable to that in subjects without SCD from prior studies. Methadone produced more pain relief than standard care in children with SCD. Higher methadone doses may be more effective and should be evaluated in both children and adults with SCD.
Investigation of the Lithiation Mechanism of Fe3O4‐Based Composite Anode: the Effect of the Carbon Matrix
Authors: Yan Chenxing , Wu Chao , Zhuang Quanchao , Tian Leilei , Cui Yongli , Zhao Xing , Ju Zhicheng , Sun Xueliang 
Published: August 2016

AbstractIn this work, the Fe3O4/CNTs composite and Fe3O4/C composite were synthesized by a facile hydrothermal method without any reducing agents and pyrolysis of glucose, respectively, and the process of the first lithiation of commercial Fe3O4, Fe3O4/CNTs and Fe3O4/C electrode were systematically investigated by EIS as function of electrode potential. It is found that at intermediate degrees of intercalation, the characteristic Nyquist plots of Fe3O4 electrode are composed of three parts, namely, the small semicircle in high‐frequency region can be attributed to the migration of lithium‐ion through SEI film (the resistance of SEI film coupled with SEI film capacitance) as well as contact problems; the semicircle in the medium‐frequency region is attributed to the electronic properties of the material and the large arc in low‐frequency region is due to charge transfer step. Moreover, the changes of kinetic parameters for lithiation process of Fe3O4/CNTs composite as a function of electrode potential in the first discharge cycle was discussed in detail, and the effect of carbon matrix type on the electrochemical performance and lithiation mechanism of Fe3O4 electrode is given.
Non‐Innocent Property of Tridentate Ligand in Novel Cobalt Complex : Crystal Structure and Evidences for Cobalt(II) Phenoxyl Radical Complex Formation
Authors: Dhara Ashish Kumar , Kumar Kapil , Kumari Sheela , Singh Udai P. , Ghosh Kaushik 
Published: August 2016

AbstractA phenoxyl radical complex [CoII(L)(L+)]NO3 (where LH=(E)‐2,4‐di‐tert‐butyl‐6‐((2‐phenyl‐2‐(pyridin‐2‐yl)hydrazono)methyl)phenol and H=dissociable proton) was synthesized at room temperature in aerobic condition and was characterized. Crystal structure, UV‐Vis‐NIR and 1H‐NMR spectra, magnetic properties and electrochemical studies authenticated the presence of Co(II) phenoxyl radical complex.
Unprecedented Selective Heterogeneously Catalysed “Green” Oxidation of Betulin to Biologically Active Compounds using Synthetic Air and Supported Ru Catalysts
Authors: Mäki‐Arvela Päivi , Barsukova Maria , Winberg Iris , Smeds Annika , Hemming Jarl , Eränen Kari , Torozova Alexandra , Aho Atte , Volcho Konstantin , Murzin Dmitry Yu. 
Published: August 2016

AbstractSelective oxidation of betulin to biologically active betulinic aldehyde is demonstrated for the first time over Ru/C catalyst mixed with a basic hydrotalcite and using SiO2 as a dehydrating agent in synthetic air at 108 °C in toluene with conversion of 41 % in 24 h and 67 % selectivity to betulinic aldehyde, whereas without SiO2 with Ru/C the corresponding conversion and selectivity values were 20 % and 66 %, respectively. Over another, acidic Ru/C catalyst even higher conversion was achieved, giving, however, allobetulin as a main product. These results indicate that basicity and absence of water are crucial for selective botulin oxidation over Ru catalysts. The conversion levels are comparative with the results in the oxidation of hydroxymathylfurfural, which contains a hydroxymethyl group attached to the heterocyclic ring.
Potent 1,2,4‐Triazole‐3‐thione Radical Scavengers Derived from Phenolic Acids: Synthesis, Electrochemistry, and Theoretical Study
Authors: Ivanović Nevena , Jovanović Ljiljana , Marković Zoran , Marković Violeta , Joksović Milan D. , Milenković Dejan , Djurdjević Predrag T. , Ćirić Andrija , Joksović Ljubinka 
Published: August 2016

AbstractNine 1,2,4‐triazole‐3‐thiones containing phenolic acid moiety have been synthesized and examined by scavenging of stable DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) radical, measurement of reducing capacity, cyclic voltammetry experiments and density functional theory (DFT). The differences in DPPH‐radical scavenging activity of the compounds 4 a‐i are affected by the stability of the corresponding radicals or radical cations and possibility of delocalization of unpaired electron through benzene and triazole ring. Significantly, lower proton affinity (PA) values than bond dissociation enthalpy (BDE) indicate SPLET (sequential proton loss electron transfer) mechanism under these experimental conditions.
Uncertainty Principle in the Elucidation of the Extraction Mechanism of Ions from Aqueous towards Ionic Liquid Phases. PtCl62− and [C1C8IM][NTf2] as a Textbook Case
Authors: Papaiconomou Nicolas , Cointeaux Laure , Chainet Eric , Iojoiu Cristina , Billard Isabelle 
Published: August 2016

AbstractThe extraction mechanism of Pt(IV) from aqueous HCl solutions towards the ionic liquid 1‐octyl‐3‐methylimidazolium bis(trifluoromethanesulfonyl)imide ([C1C8IM][NTf2]) is deciphered. To that end, aqueous speciation of Pt(IV) as a function of HCl was studied by 195Pt NMR. Influence of the concentration of HCl (ranging from 1 to 12 M) and of the initial concentration of Pt(IV) (ranging from 10−5 to 10−2 M) in the aqueous phase on the distribution coefficients of Pt(IV) was systematically investigated. The decrease in D with the concentrations of HCl and Pt(IV) observed is quantitatively very well described with a model using three chemical equilibria, namely the solubility of the ionic liquid in water, the extraction of PtCl62− through an ion‐pair formation and that of Cl− towards the ionic liquid phase. D values were then predicted over a wider range of concentrations for HCl and PtCl62−. Alternatively, the extraction of PtCl62− was described using an anion exchange hypothesis and it is demonstrated that these two apparently different mechanisms are actually equivalent within hydrophobic ionic liquids. Because the two versions of the extraction model presented here are not specific to PtCl62− or the ionic liquid, they can be generalized to the extraction of any charged (metal) complex and any hydrophobic ionic liquid, allowing us to outline a general uncertainty principle in the determination of extraction mechanisms in systems involving ionic liquids
Palladium Nanoparticles Supported Carbon Based Graphene Oxide Monolith as Catalyst for Sonogashira Coupling and Hydrogenation of Nitrobenzene and Alkenes
Authors: Nakhate Akhil V. , Yadav Ganapati D. 
Published: August 2016

AbstractSynthesis of palladium nanoparticles supported on carbon based graphene oxide monolith (Pd@CGO monolith) is reported here. It was prepared by solvothermal carbonization of glucose with small amount of graphene oxide (GO) as structure directing agent. It provides large and flat surface for anchoring Pd nanoparticles. CGO monolith impedes Pd particles migration and increases interaction between Pd nanoparticles and support, which leads to enhanced activity. It was used in Sonogashira coupling and hydrogenation of alkenes and nitrobenzene. The activity of Pd@CGO monolith was compared with 5 % Pd@GO and 5 % Pd/C for Sonogashira coupling of phenylacetylene with iodobenzene. Pd@CGO monolith showed excellent conversion (93 %) at 90 °C with low catalyst loading (1×10−3 g/cm3) under ligand and copper free reaction conditions. Pd@CGO monolith was well characterized by different analytical techniques. The effect of solvent, base, speed of agitation, mole ratio, catalyst loading and temperature was studied using Pd@CGO monolith. Also, a reaction mechanism was proposed and kinetic model developed. The catalyst was recycled up to four times with no loss of activity. It was highly stable showing no Pd leaching.
Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor‐α from Natural Products using Receptor‐Ligand Recognition
Authors: Luo Qiang , Wang Zhaokai , Chen Huibin , Fang Ms. Hui , Xie Shouqi , Qian Xueqiao , Lin Xiangzhi 
Published: August 2016

AbstractNatural products (NP), especially medicinal plants, have been used worldwide to treat numerous diseases for thousands of years. However, drug discovery focus has been moving away from identifying lead compounds from complex mixtures of crude NP because this approach is technically difficult and inefficient. We here present a quick, accurate and practical method for screening leads targeting a nuclear receptor from NP mixtures. Using themethod, we rapidly identified erythrotriol as a new lead compoundfrom medicinal plant Hibiscus syriacus L.targeting RXRα for treating cancer with less side effects. This method can efficiently and profitably screen lead compounds targeting nuclear receptors and may reinvigorate interest in NP as sources of pharmaceutical agents.