bluuebunny/crossref_metadata_2025_split huggingface dataset:
The “Notch” in Unstable Layers and the Stability Minimum in the Tropics
Authors: Geller Marvin A. , Wang Ling 
Published: October 2024

Abstract
In a previous paper, we identified a “notch” in unstable layers at Koror (7.3°N, 134.5°E), where there was a relative deficiency in thin unstable layers and a corresponding relative excess in thicker layers, at altitudes centered at 12 km. We hypothesized that this feature was associated with the previously identified stability minimum in the tropics at that same altitude. In this paper, we extend our studies of this notch and its association with the tropical stability minimum by examining other stations in the deep tropics and also some stations at higher latitudes within the tropics. We find that this notch feature is found at all the other radiosonde stations in the deep tropics that we examined. We also find that the annual variations in unstable layer occurrences at stations at higher latitudes within the tropics show variations consistent with our hypothesis that this notch is associated with the region of minimum stability in the tropics at altitudes centered around 12 km, in that the annual variation in this notch feature is consistent with the annual variation of minimum stability in this region. Two factors contribute to the notch feature. One is that the data quality control procedure of the analysis rejects many thin layers due to the small trend-to-noise ratio in the region of minimum stability. The other is that the cloud-top outflow, which was previously identified with the stability minimum, advects thicker unstable layers throughout the deep tropics at the altitudes of the notch.

Significance Statement
Previous papers have separately identified a stability minimum in the tropics and a “notch” feature in the thicknesses of unstable atmospheric layers where there are less thin unstable layers and a corresponding excess of thicker unstable layers, both at altitudes around 12 km. We previously hypothesized that these two features were associated with one another. In this paper, we examine this notch feature and the minimum in atmospheric stability at both deep tropical radiosonde stations and stations located at higher latitudes in the tropics, and we find that the annual variation of this notch feature is consistent with the latitudinal migration of the latitudes of the stability minimum. Turbulence associated with this notch feature might be significant for aircraft operations.
Oil Price Uncertainty and Consumer Sentiment in Advanced Economies
Authors: Azad Nahiyan Faisal , Serletis Apostolos 
Published: October 2024

How does oil price uncertainty affect consumer sentiment in advanced economies? Is the response of consumer sentiment to exogenous positive and negative oil price shocks symmetric or asymmetric? Motivated to answer these questions, this paper provides a comprehensive examination of the effects of real oil price shocks on consumer sentiment in the G7 economies in the context of two classes of empirical models. With the application of a bivariate structural GARCH-in-Mean VAR model we find that (in general) oil price uncertainty has a negative and statistically significant effect on consumer sentiment in the G7 countries. Moreover, using a test of symmetry, we find that the relationship between oil prices and consumer sentiment is in general asymmetric. JEL Classification: C32, D12, Q43, O57
A stented elephant trunk procedure with retrograde cerebral perfusion for a rare type of pseudoaneurysm with an aberrant right subclavian artery
Authors: Yang Tao , Zheng Zhifa , Yang Lingbo , Wu Nan , Liu Zhenhao , Wang Xuening 
Published: October 2024

Background Aberrant right subclavian artery (ARSA) is a rare congenital vascular anomaly that increases the risk of aortic dissection (AD). Although several treatment options for cases of AD with ARSA have been proposed, such as traditional surgery, thoracic endovascular aortic repair, and a hybrid procedure, a consensus regarding the optimal treatment strategy has not yet been established. And there are no reported cases of pseudoaneurysm combined with ARSA. Case presentation A 44-year-old male was admitted with a 7-days history of chest pain. A physical examination was almost normal. Computed tomography angiography (CTA) showed an ARSA arose from the distal aortic arch and pseudoaneurysm located distal to the origin of the ARSA. The stented elephant trunk (SET) procedure with retrograde cerebral perfusion (RCP) was performed under moderate hypothermic circulatory arrest. The postoperative CTA demonstrated a well-perfused ARSA, left subclavian artery (LSA), left common carotid artery (LCCA), and right common carotid artery (RCCA), and occluded pseudoaneurysm with no endoleaks. He was discharged on postoperative day 9 and was doing well during his 6-months follow-up. Conclusions With a smaller incision, a simple cannulation method, shorter surgical and circulatory arrest times, fewer blood transfusion requirements, and effective brain protection, the SET procedure with RCP can be a safe and feasible treatment option for complicated aortic arch anomalies with ARSA.
Selective monitoring of superior and inferior vena cava drainage flows in bicaval cannulation: Potential clinical benefits of proximal junction placement on the CPB side
Authors: Condello Ignazio , Montemurro Vincenzo , De Rosis Maria Grazia , Nasso Giuseppe 
Published: October 2024

Background: In cardiac surgery, precision and efficiency are crucial, especially in managing venous drainage flows during complex procedures. This practical technique evaluates the benefits of placing the proximal junction on the cardiopulmonary bypass (CPB) side rather than on the surgical table in bicaval cannulation. Bicaval cannulation, involving both the superior vena cava (SVC) and inferior vena cava (IVC), ensures efficient venous return. Practical technique: Placing the junction on the CPB side allows for accurate, real-time control of venous drainage, allowing for swift responses to fluctuations and maintaining stable hemodynamics. Perspectives: This approach could minimize the risk of congestion in the liver, splanchnic system, and cerebral venous return, thereby preventing related complications. Another important potential benefit of this approach could be the ability to closely monitor and manage metabolic demands and oxygen consumption for SVC and IVC. Additionally, EmTec flow technology can be integrated for more precise management.
Systematic review of ultrasound-guided central venous catheter placement-related complications in neonates and infants aged <12 months
Authors: Cui Yu , Wang Yu , Gong Tianqing , Huang Qinghua , Zhang Qian-Qian 
Published: October 2024

Objective Although ultrasound can be considered an assistant method, successful placement of a central venous catheter (CVC) in infants is still challenging. The incidence of CVC placement-related complications is still high. Therefore, this systematic review aimed to synthesize evidence to assess the effects of ultrasound-guided CVC placement on adverse outcomes in infants and neonates aged <12 months. Methods PubMed, Ovid, EMBASE, and the Cochrane Library were searched to identify potentially relevant studies. The main outcome was the incidence of adverse events, which included inadvertent arterial puncture, hematoma, pneumothorax and hemothorax, catheter kinking, threading, and malpositioning problems, venous thrombosis, catheter-related infection, phlebitis, and cardiac tamponade. Results Eleven studies involving 2097 patients were included in the final analysis. The odds of inadvertent arterial puncture, and catheter kinking, threading, and malpositioning problems were lower in the ultrasound group than in the control group. No significant difference was detected in the incidence of hematoma or venous thrombosis between the control and ultrasound groups. Other complications, such as pneumothorax, hemothorax, phlebitis, and cardiac tamponade, rarely occurred. Conclusion Ultrasound-guided CVC placement can improve the safety of punctures in neonates and infants. CVC punctures should be guided in real-time by ultrasound.
Migraine and work – beyond absenteeism: Migraine severity and occupational burnout – A cohort study
Authors: Peles Ido , Sharvit Shaked , Zlotnik Yair , Gordon Michal , Novack Victor , Waismel-Manor Ronit , Ifergane Gal 
Published: October 2024

Background Migraine, a condition affecting 12% of the population, is a prevalent cause of disability, significantly impacts individuals during their most productive working years. Several studies have established that a migraine patient's job performance is often limited by absenteeism and presenteeism. The present study aimed to investigate the impact of migraines on occupational burnout, which affects up to 40% of workers. Methods A subset of participants from the Negev Migraine Cohort, including both migraine patients and non-migraine controls, were asked to complete the study questionnaire. The main exposures of interest were migraine diagnosis and severity. The primary outcome was occupational burnout. Migraine severity and associated disability were evaluated using the Migraine Disability Assessment (MIDAS) score, psychiatric comorbidities using the Depression, Anxiety and Stress Scale – 21 Items (DASS-21) scale and occupational burnout using the Maslach Burnout Inventory (MBI-GS version) scale. Statistical analyses included multivariable quantile regression models to identify associations and adjust for potential confounders. Results In total, 675 migraine patients and 232 non-migraine participants participated in the study. Migraine patients exhibited higher rates of depression (mean DASS-21: 0.864 vs. 0.664, standardized mean difference (SMD) = 0.262), tended to work longer hours (median weekly hours: 40.0 vs. 36.0, SMD = 0.148) and expressed a preference for remote work (20.3% vs. 10.3%, SMD = 0.097). Migraine patients reported significantly higher levels of occupational burnout (mean burnout score: 3.46 vs. 2.82, SMD = 0.469). Controlling for depression, anxiety and stress, migraine diagnosis (25th percentile estimate = 0.67, p = 0.002, 75th percentile estimate = 0.92, p = 0.032) and migraine severity (estimates: 2.2–5.3, p < 0.001 for all) were associated with higher levels of occupational burnout. Conclusions Migraine diagnosis and severity is associated with an occupational burnout, after controlling for various psychological and work-related factors. The findings underscore the need for workplace adjustments to support migraine patients’ participation in the work market.
CircLPHN3 correlates with prognosis in colorectal cancer and regulates cellular processes by targeting miR-142-5p
Authors: Zhang JiWen , Cai Yan 
Published: October 2024

Background Colorectal cancer (CRC) is often diagnosed late and has a poor prognosis. Circular RNAs (circRNAs) have been identified as prognostic biomarkers in various cancers, including CRC. Objective The objective was to elucidate the role of circLPHN3 (hsa_circ_0069865) in CRC progression and to provide a promising prognostic marker for CRC. Methods CircLPHN3 was identified through bioinformatics analysis of the GSE121842 dataset. The levels of circLPHN3 in CRC samples were analyzed by real time-quantitative polymerase chain reaction. Its clinical significance was assessed using the Kaplan–Meier curve and multivariate Cox regression. Downstream microRNAs of circLPHN3 were predicted with the RNAhybrid, Circular RNA Interactome, and starBase online databases. The target of miR-142-5p was predicted using miRDB, TargetScanHuman, starBase, and miRWalk databases. The relationship between circLPHN3, miR-142-5p, and LDB2 was verified by dual luciferase reporter assay. The function of circLPHN3 on CRC cell growth and metastasis was measured using Transwell and the cell counting kit-8 assay. Results Significant downregulation of circLPHN3 was found in CRC. CircLPHN3 was closely related to higher tumor node metastasis stage, lymph node metastasis, and predicted unfavorable prognosis. miR-142-5p was highly expressed in CRC and its expression was negatively regulated by circLPHN3. Overexpression of circLPHN3 curbed CRC cell growth, migration, and invasion, mediated by miR-142-5p. Moreover, LDB2 was identified as a target of miR-142-5p. Conclusion CircLPHN3 acted as a prognostic biomarker and tumor suppressor for CRC via modulating miR-142-5p.
SMC4 serves as a potential marker for the diagnosis and prognosis of colon adenocarcinoma
Authors: Yang Dawei , Cheng Wenxin , Liu Ying , Ma Liang , Sun Yao , Wang Hongzhen , Liu Haifeng , Nan Li , Yang Yang , Wang Xinyue 
Published: October 2024

Objective We aimed to explore the role of structural maintenance of chromosomes 4 (SMC4) in malignant progression and immunology of colon adenocarcinoma (COAD). Methods The expression, genetic and protein features, and immune cell infiltration of SMC4 in pan-cancer were provided by public databases and websites. The protein expression of SMC4 in COAD tissues was screened by immunohistochemical assay. Si-RNA-mediated transfection was performed in COAD cells and the proliferation viability was measured using MTT, colony formation and EdU assays. Cell autophagy was detected by AO staining, western blots, and immunofluorescence staining. The migratory ability was determined using scratch and transwell assays. The expression of epithelial-to-mesenchymal transition (EMT) markers and transcriptional factors were detected using western blots. Results The expression of SMC4 was upregulated in pan-cancer and had relationships with prognosis, TMB, and MSI of cancer patients. Particularly, SMC4 protein was highly expressed in COAD tissues and correlated with poor prognosis of patients. Depletion of SMC4 inhibited cell proliferation, induced autophagy, and decreased migration through EMT progression in COAD cells. In addition, SMC4 was associated with infiltration of neutrophils, M2 macrophages, and CD4 + T cells in COAD, and had positive association with M2 macrophage markers and immune checkpoints. Conclusion SMC4 was correlated with patients’ poor prognosis, proliferation, metastasis, and immune cell infiltrates, and might function as a potential diagnosis and prognostic biomarker in COAD.
Lessons from a Pilot Study of a Culturally Tailored Financial Well-Being Intervention Among Latino Family Caregivers
Authors: Meyer Kylie , Mage Susanna M. , Gonzalez Alexander , Zauszniewski Jaclene A. , Rhodes Shanae , Perales-Puchalt Jaime , Wilber Kathleen , Song Lixin , Puga Frank , Benton Donna 
Published: October 2024

Financial strain disproportionally affects the growing population of Latino family caregivers. This pilot study aimed to test the feasibility of a culturally tailored psychoeducational intervention for Latino caregivers designed to reduce financial strain by improving resourcefulness and self-efficacy. Feasibility was assessed according to participant demands, ability to deliver the intervention, and preliminary efficacy. From May 2022 to September 2023, Confidently Navigating Financial Decisions and Enhancing Financial Wellbeing in Dementia Caregiving (CONFIDENCE) was administered to 69 caregivers over 11 cohorts in a community setting. Caregivers attended an average of 3.13 ( SD = 0.17) of five sessions. Eligible caregivers were given the option to participate in a single-arm pre- and post-test study. Results from N = 20 caregivers indicated reduced levels of financial strain 2 months post-intervention ( p-value = .013). Findings also showed improvements resourcefulness and self-efficacy. Although CONFIDENCE appears feasible to deliver and may affect desired outcomes, future studies should reduce intervention demands to improve attendance. Trial Registration This trial is registered at ClinicalTrials.gov (NCT05292248).
Determinants of Breast Cancer Screening Adherence During the COVID-19 Pandemic in a Cohort at Increased Inherited Cancer Risk in the United States
Authors: Harris Adrian , Bather Jemar R. , Kawamoto Kensaku , Fiol Guilherme Del , Bradshaw Richard L. , Kaiser-Jackson Lauren , Monahan Rachel , Kohlmann Wendy , Liu Feng , Ginsburg Ophira , Goodman Melody S. , Kaphingst Kimberly A. 
Published: October 2024

Background We examined neighborhood characteristics concerning breast cancer screening annual adherence during the COVID-19 pandemic. Methods We analyzed 6673 female patients aged 40 or older at increased inherited cancer risk in 2 large health care systems (NYU Langone Health [NYULH] and the University of Utah Health [UHealth]). Multinomial models were used to identify predictors of mammogram screening groups (non-adherent, pre-pandemic adherent, pandemic period adherent) in comparison to adherent females. Potential determinants included sociodemographic characteristics and neighborhood factors. Results Comparing each cancer group in reference to the adherent group, a reduced likelihood of being non-adherent was associated with older age (OR: 0.97, 95% CI: 0.95, 0.99), a greater number of relatives with cancer (OR: 0.80, 95% CI: 0.75, 0.86), and being seen at NYULH study site (OR: 0.42, 95% CI: 0.29, 0.60). More relatives with cancer were correlated with a lesser likelihood of being pandemic period adherent (OR: 0.89, 95% CI: 0.81, 0.97). A lower likelihood of being pre-pandemic adherent was seen in areas with less education (OR: 0.77, 95% CI: 0.62, 0.96) and NYULH study site (OR: 0.35, 95% CI: 0.22, 0.55). Finally, greater neighborhood deprivation (OR: 1.47, 95% CI: 1.08, 2.01) was associated with being non-adherent. Conclusion Breast screening during the COVID-19 pandemic was associated with being older, having more relatives with cancer, residing in areas with less educational attainment, and being seen at NYULH; non-adherence was linked with greater neighborhood deprivation. These findings may mitigate risk of clinically important screening delays at times of disruptions in a population at greater risk for breast cancer.
Examining the Association Between Adverse Childhood Experiences and ADHD in School-Aged Children Following the COVID-19 Pandemic
Authors: Boswell Emma , Crouch Elizabeth , Odahowski Cassie , Hung Peiyin 
Published: October 2024

Background: Adverse childhood experiences (ACEs) have long been associated with attention-deficit/hyperactive disorder (ADHD) diagnoses in children; but the data used is now over 6 years old (from 2017 to 2018). Understanding the current landscape of their prevalence and association is needed to capture evolving social, environmental, and economic conditions, and ensure interventions remain relevant to addressing current childhood trauma. Objective: This study provides an updated analysis of the association between ACEs and ADHD using post-acute-COVID-19 pandemic data. Participants and Setting: This cross-sectional study of 10,518 children aged 5 to 17 years old derived data from the 2021 to 2022 National Health Interview Survey (NHIS). Methods: Differences in the prevalence of number (0, 1–3, or 4+) and type of ACEs by ADHD diagnosis were evaluated using Rao-Scott chi-square tests and multivariable logistic regression. All analyses incorporate complex survey weights. Results: In 2021 to 2022, 2,457 (23.3%) of children experienced ACEs and 1,115 (9.9%) had an ADHD diagnosis. Children with ADHD were more likely to experience every type of ACE and were more likely to have 1 to 3 or 4+ ACEs than children without ADHD. Children with 4+ ACEs had higher odds of having an ADHD diagnosis (aOR: 3.44, 95% CI [2.64, 4.49]) than children without ACEs. Male children, children with fair or poor health, and children living in rural counties were more likely to have an ADHD diagnosis, while children of color and uninsured children were less likely. We found the odds ratio of ADHD diagnosis for children with four or more ACEs, compared to those without ACEs, slightly lower than found in Brown et al., 2017’s estimate of 3.97 (CI [3.29, 4.80]). These results suggest a consistent association between ACEs and ADHD when comparing pre-COVID data to our post-acute-COVID results. Conclusions: These findings highlight the need for clinicians to consider traumatic stress in ADHD screening. Policymakers and early childhood organizations should encourage early screening and intervention for ACEs to reduce the impacts of ADHD diagnoses.
Rotavirus in Water Environments: A Systematic Review and Meta-Analysis
Authors: Awere-Duodu Aaron , Donkor Eric S 
Published: October 2024

Background: Despite the adoption of rotavirus vaccines, sporadic outbreaks of the virus have been reported in many parts of the world. These outbreaks are facilitated by several factors including the ease of transmission of rotavirus through water environments. This systematic review aimed to determine the global prevalence of rotavirus in water environments. Methodology: Comprehensive Boolean searches were conducted in PubMed, SCOPUS, and Web of Science. A total of 75 eligible studies were included in the study, from which data was extracted for both systematic review and meta-analysis. Extracted prevalence data was grouped according to six water categories: drinking water, untreated sewage, treated sewage, surface water, groundwater, and others. A single-group prevalence meta-analysis was conducted in RStudio version 4.3.3 subjecting the data to the random-effects model. Results: The included studies were conducted in 32 countries that span 5 continents: Africa, Asia, Europe, North America, and South America. The pooled prevalence of rotavirus in water environments was 40.86%. Among the individual water environments, untreated sewage had the highest prevalence (68.27%), followed by treated sewage (53.07%), surface water (33.40%), groundwater (25.64%) and drinking water (9.46%). Continental stratification of the prevalence data was as follows: Africa (51.75%), Asia (32.48%), Europe (55.90%), North America (41.80%), and South America (28.51%). Conclusion: There is a high prevalence of rotavirus in water environments, especially in untreated sewage, and in Europe. Further research is needed to find more efficient methods that can effectively eliminate rotavirus to insignificant levels in water environments.
Impact of serum neurofilament light on clinical decisions in a tertiary multiple sclerosis clinic
Authors: van Lierop Zoë YGJ , Wessels Mark HJ , Lekranty Womei ML , Moraal Bastiaan , Hof Sam N , Hogenboom Laura , de Jong Brigit A , Meijs Nandi , Mensing Liselore A , van Oosten Bob W , Sol Nik , van Kempen Zoé LE , Vermunt Lisa , Willems Myrthe J , Strijbis Eva MM , Uitdehaag Bernard MJ , Killestein Joep , Teunissen Charlotte E 
Published: October 2024

Background and objectives: Serum neurofilament light (sNfL) is a biomarker for neuro-axonal damage in multiple sclerosis (MS). Clinical implementation remains limited. We investigated the impact of implementation on clinical decisions using questionnaires at the MS Center Amsterdam, a tertiary outpatient clinic. Methods: sNfL assessments were added to routine clinical practice (August 2021–December 2022). Before and after the results, clinicians filled in questionnaires on context of testing, clinical decisions, certainty herein, expectation of magnetic resonance imaging (MRI) activity, urgency, and motivation to receive the sNfL result and perceived value of sNfL. Results: sNfL was assessed in 166 cases (age 41 ± 12 years, 68% female, 64% disease-modifying therapy (DMT) use) for the following contexts: “DMT monitoring” (55%), “new symptoms” (18%), “differential diagnosis” (17%), and “DMT baseline” (11%). Clinical decisions changed in 19.3% of cases post-disclosure, particularly in context “new symptoms” (38%) and with higher sNfL levels (β = 0.03, p = 0.04). Certainty increased ( p = 0.004), while expectation of MRI activity decreased with disclosure of low sNfL levels ( p = 0.01). Motivation was highest in context “differential diagnosis” ( p < 0.001); perceived value and urgency were highest in context “new symptoms” ( p = 0.02). Conclusion: In this study, sNfL implementation had considerable impact on clinical decision-making and certainty herein. Standard implementation may complement patient care but warrants caution and more exploration in diverse clinical settings