bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating microsecond circuit switching into the data center
Authors: Porter George , Strong Richard , Farrington Nathan , Forencich Alex , Chen-Sun Pang , Rosing Tajana , Fainman Yeshaiahu , Papen George , Vahdat Amin 
Published: June 2016

Recent proposals have employed optical circuit switching (OCS) to reduce the cost of data center networks. However, the relatively slow switching times (10--100 ms) assumed by these approaches, and the accompanying latencies of their control planes, has limited its use to only the largest data center networks with highly aggregated and constrained workloads. As faster switch technologies become available, designing a control plane capable of supporting them becomes a key challenge.
In this paper, we design and implement an OCS prototype capable of switching in 11.5 us, and we use this prototype to expose a set of challenges that arise when supporting switching at microsecond time scales. In response, we propose a microsecond-latency control plane based on a circuit scheduling approach we call Traffic Matrix Scheduling (TMS) that proactively communicates circuit assignments to communicating entities so that circuit bandwidth can be used efficiently.
Bringing cross-layer MIMO to today's wireless LANs
Authors: Kumar Swarun , Cifuentes Diego , Gollakota Shyamnath , Katabi Dina 
Published: June 2016

Recent years have seen major innovations in cross-layer wireless designs. Despite demonstrating significant throughput gains, hardly any of these technologies have made it into real networks. Deploying cross-layer innovations requires adoption from Wi-Fi chip manufacturers. Yet, manufacturers hesitate to undertake major investments without a better understanding of how these designs interact with real networks and applications.
This paper presents the first step towards breaking this stalemate, by enabling the adoption of cross-layer designs in today's networks with commodity Wi-Fi cards and actual applications. We present OpenRF, a cross-layer architecture for managing MIMO signal processing. OpenRF enables access points on the same channel to cancel their interference at each other's clients, while beamforming their signal to their own clients. OpenRF is self-configuring, so that network administrators need not understand MIMO or physical layer techniques.
We patch the iwlwifi driver to support OpenRF on off-the-shelf Intel cards. We deploy OpenRF on a 20-node network, showing how it manages the complex interaction of cross-layer design with a real network stack, TCP, bursty traffic, and real applications. Our results demonstrate an average gain of 1.6x for TCP traffic and a significant reduction in response time for real-time applications, like remote desktop.
Don't drop, detour!
Authors: Calder Matt , Miao Rui , Zarifis Kyriakos , Katz-Bassett Ethan , Yu Minlan , Padhye Jitendra 
Published: June 2016

Today's data centers must support a range of workloads with different demands. While existing approaches handle routine traffic smoothly, ephemeral but intense hotspots cause excessive packet loss and severely degrade performance. This loss occurs even though the congestion is typically highly localized, with spare buffer capacity available at nearby switches.
We argue that switches should share buffer capacity to effectively handle this spot congestion without the latency or monetary hit of deploying large buffers at individual switches. We present detour-induced buffer sharing (DIBS), a mechanism that achieves a near lossless network without requiring additional buffers. Using DIBS, a congested switch detours packets randomly to neighboring switches to avoid dropping the packets. We implement DIBS in hardware, on software routers in a testbed, and in simulation, and we demonstrate that it reduces the 99th percentile of query completion time by 85%, with very little impact on background traffic.
Profiling of 149 Salivary Duct Carcinomas, Carcinoma Ex Pleomorphic Adenomas, and Adenocarcinomas, Not Otherwise Specified Reveals Actionable Genomic Alterations
Authors: Wang Kai , Russell Jeffery S. , McDermott Jessica D. , Elvin Julia A. , Khaira Depinder , Johnson Adrienne , Jennings Timothy A. , Ali Siraj M. , Murray Molly , Marshall Carrie , Oldham Dwight S. , Washburn Donna , Wong Stuart J. , Chmielecki Juliann , Yelensky Roman , Lipson Doron , Miller Vincent A. , Stephens Philip J. , Serracino Hilary S. , Ross Jeffrey S. , Bowles Daniel W. 
Published: June 2016

Abstract
Purpose: We sought to identify genomic alterations (GA) in salivary gland adenocarcinomas, not otherwise specified (NOS), salivary duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca ex PA), and salivary carcinoma, NOS.
Experimental Design: DNA was extracted from 149 tumors. Comprehensive genomic profiling (CGP) was performed on hybridization-captured adaptor ligation-based libraries of 182 or 315 cancer-related genes plus introns from 14 or 28 genes frequently rearranged for cancer and evaluated for all classes of GAs.
Results: A total of 590 GAs were found in 157 unique genes (mean 3.9/tumor). GAs in the PI3K/AKT/mTOR pathway were more common in SDC (53.6%) than other histologies (P = 0.019) Cyclin-dependent kinase GAs varied among all histotypes: adenocarcinoma, NOS (34.6%); SDC (12.2%); ca ex PA (16.7%); carcinoma, NOS (31.2%; P = 0.043). RAS GAs were observed: adenocarcinoma, NOS (17.3%); SDC (26.8%); ca ex PA (4.2%); and carcinoma, NOS (9.4%; P = 0.054). ERBB2 GAs, including amplifications and mutations, were common: adenocarcinoma, NOS (13.5%); SDC (26.8%); ca ex PA (29.2%); carcinoma, NOS (18.8; P = 0.249). Other notable GAs include TP53 in &gt;45% of each histotype; NOTCH1: adenocarcinoma, NOS (7.7%), ca ex PA (8.3%), carcinoma, NOS (21.6%); NF1: adenocarcinoma, NOS (9.6%), SDC (17.1%), carcinoma, NOS (18.8%). RET fusions were identified in one adenocarcinoma, NOS (CCDC6-RET) and two SDCs (NCOA4-RET). Clinical responses were observed in patients treated with anti-HER2 and anti-RET–targeted therapies.
Conclusions: CGP of salivary adenocarcinoma, NOS, SDCs, ca ex PA, and carcinoma, NOS revealed diverse GAs that may lead to novel treatment options. Clin Cancer Res; 22(24); 6061–8. ©2016 AACR.
Colony-Stimulating Factor-1 Receptor Is Required for Nurse-like Cell Survival in Chronic Lymphocytic Leukemia
Authors: Polk Avery , Lu Ye , Wang Tianjiao , Seymour Erlene , Bailey Nathanael G. , Singer Jack W. , Boonstra Philip S. , Lim Megan S. , Malek Sami , Wilcox Ryan A. 
Published: June 2016

AbstractPurpose: Monocytes and their progeny are abundant constituents of the tumor microenvironment in lymphoproliferative disorders, including chronic lymphocytic leukemia (CLL). Monocyte-derived cells, including nurse-like cells (NLC) in CLL, promote lymphocyte proliferation and survival, confer resistance to chemotherapy, and are associated with more rapid disease progression. Colony-stimulating factor-1 receptor (CSF-1R) regulates the homeostatic survival of tissue-resident macrophages. Therefore, we sought to determine whether CSF-1R is similarly required for NLC survival.Experimental Design: CSF-1R expression by NLC was examined by flow cytometry and IHC. CSF-1R blocking studies were performed using an antagonistic mAb to examine its role in NLC generation and in CLL survival. A rational search strategy was performed to identify a novel tyrosine kinase inhibitor (TKI) targeting CSF-1R. The influence of TKI-mediated CSF-1R inhibition on NLC and CLL viability was examined.Results: We demonstrated that the generation and survival of NLC in CLL is dependent upon CSF-1R signaling. CSF-1R blockade is associated with significant depletion of NLC and consequently inhibits CLL B-cell survival. We found that the JAK2/FLT3 inhibitor pacritinib suppresses CSF-1R signaling, thereby preventing the generation and survival of NLC and impairs CLL B-cell viability.Conclusions: CSF-1R is a novel therapeutic target that may be exploited in lymphoproliferative disorders, like CLL, that are dependent upon lymphoma-associated macrophages. Clin Cancer Res; 22(24); 6118–28. ©2016 AACR.
Tumor Microenvironment in Gene Signatures: Critical Biology or Confounding Noise?
Authors: Morris Jeffrey S. , Kopetz Scott 
Published: June 2016

Abstract
The tumor microenvironment contributes important information in gene expression signatures but may be susceptible to sampling variance. Mesenchymal signatures in particular may be influenced by sampling of nonrepresentative regions with high stromal content. Appropriate pathology quality control is required to ensure reproducibility of gene expression signatures. Clin Cancer Res; 22(16); 3989–91. ©2016 AACR.
See related article by Dunne et al., p. 4095
International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents
Authors: Parmar Priyakumari Ganesh , Taal H. Rob , Timpson Nicholas J. , Thiering Elisabeth , Lehtimäki Terho , Marinelli Marcella , Lind Penelope A. , Howe Laura D. , Verwoert Germaine , Aalto Ville , Uitterlinden Andre G. , Briollais Laurent , Evans Dave M. , Wright Margie J. , Newnham John P. , Whitfield John B. , Lyytikäinen Leo-Pekka , Rivadeneira Fernando , Boomsma Dorrett I. , Viikari Jorma , Gillman Matthew W. , St Pourcain Beate , Hottenga Jouke-Jan , Montgomery Grant W. , Hofman Albert , Kähönen Mika , Martin Nicholas G. , Tobin Martin D. , Raitakari Ollie , Vioque Jesus , Jaddoe Vincent W.V. , Jarvelin Marjo-Riita , Beilin Lawrence J. , Heinrich Joachim , van Duijn Cornelia M. , Pennell Craig E. , Lawlor Debbie A. , Palmer Lyle J. 
Published: June 2016

Background—
Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.

Methods and Results—

Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4–7 years), puberty (8–12 years), and postpuberty (13–20 years). Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (
ITGA11
, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5′-C-phosphate-G-3′ methylation site) during prepuberty (
P
=2.86×10
–8
) and rs872256 during puberty (
P
=8.67×10
–9
). Several single-nucleotide polymorphism clusters were also associated with childhood BP at
P
<5×10
–3
. Using a
P
value threshold of <5×10
–3
, we found some overlap in variants across the different age epochs within our study and between several single-nucleotide polymorphisms in any of the 3 epochs and adult BP-related single-nucleotide polymorphisms.

Conclusions—
Our results suggest that genetic determinants of BP act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women
Authors: Kangas Pauliina , Tahvanainen Anna , Tikkakoski Antti , Koskela Jenni , Uitto Marko , Viik Jari , Kähönen Mika , Kööbi Tiit , Mustonen Jukka , Pörsti Ilkka 
Published: June 2016

Background
Men and women differ in the risk of cardiovascular disease, but the underlying mechanisms are not completely understood. We examined possible sex‐related differences in supine and upright cardiovascular regulation.

Methods and Results

Hemodynamics were recorded from 167 men and 167 women of matching age (≈45 years) and body mass index (≈26.5) during passive head‐up tilt. None had diabetes mellitus or cardiovascular disease other than hypertension or used antihypertensive medication. Whole‐body impedance cardiography, tonometric radial blood pressure, and heart rate variability were analyzed. Results were adjusted for height, smoking, alcohol intake, mean arterial pressure, plasma lipids, and glucose. Supine hemodynamic differences were minor: Men had lower heart rate (−4%) and higher stroke index (+7.5%) than women (
P
<0.05 for both). Upright systemic vascular resistance was lower (−10%), but stroke index (+15%), cardiac index (+16%), and left cardiac work were clearly higher (+20%) in men than in women (
P
<0.001 for all). Corresponding results were observed in a subgroup of men and postmenopausal women (n=76, aged >55 years). Heart rate variability analyses showed higher low:high frequency ratios in supine (
P
<0.001) and upright (
P
=0.003) positions in men.

Conclusions
The foremost difference in cardiovascular regulation between sexes was higher upright hemodynamic workload for the heart in men, a finding not explained by known cardiovascular risk factors or hormonal differences before menopause. Heart rate variability analyses indicated higher sympathovagal balance in men regardless of body position. The deviations in upright hemodynamics could play a role in the differences in cardiovascular risk between men and women.

Clinical Trial Registration

URL:
http://www.clinicaltrials.gov
. Unique identifier:
NCT
01742702.
Influence of Distance to Scene on Time to Thrombolysis in a Specialized Stroke Ambulance
Authors: Koch Peter M. , Kunz Alexander , Ebinger Martin , Geisler Frederik , Rozanski Michal , Waldschmidt Carolin , Weber Joachim E. , Wendt Matthias , Winter Benjamin , Zieschang Katja , Bollweg Kerstin , Kaczmarek Sabina , Endres Matthias , Audebert Heinrich J. 
Published: June 2016

Background and Purpose—
Specialized computed tomography–equipped stroke ambulances shorten time to intravenous thrombolysis in acute ischemic stroke by starting treatment before hospital arrival. Because of longer travel-time-to-scene, time benefits of this concept are expected to diminish with longer distances from base station to scene.

Methods—
We used data from the Prehospital Acute Neurological Treatment and Optimization of Medical Cares in Stroke (PHANTOM-S) trial comparing time intervals between patients for whom a specialized stroke ambulance (stroke emergency mobile) was deployed and patients with conventional emergency medical service. Expected times from base station to scene had been calculated beforehand using computer algorithms informed by emergency medical service routine data. Four different deployment zones with–75% probability–expected arrival within 4, 8, 12, and 16 minutes and total population coverage of ≈1.3 million inhabitants were categorized for stroke emergency mobile deployment. We analyzed times from alarm-to-arrival at scene, to start of intravenous thrombolysis and from onset-to-intravenous thrombolysis.

Results—

Corresponding to the size of the respective catchment zone, the number of patients cared increased with distance (zone 1: n=30, zone 2: n=127, zone 3: n=156, and zone 4: n=217). Although time to stroke emergency mobile arrival increased with distance (mean: 8.0, 12.5, 15.4, and 18.4 minutes in zones 1–4), time from alarm-to-intravenous thrombolysis (mean: 41.8 versus 76.5; 50.2 versus 79.1; 54.5 versus 76.6; and 59.3 versus 78.0 minutes, respectively; all
P
<0.01) remained shorter in the stroke emergency mobile group across all zones.

Conclusions—
In a metropolitan area such as Berlin, time benefits justify a specialized stroke ambulance service up to a mean travel time of 18 minutes from base station.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01382862.
Europeanization in a Difficult Environment
Authors: Knezović Sandro , Zeneli Valbona 
Published: June 2016

This article examines the impact of the process of Europeanization on the consolidation of political systems and on the pace of European Union (EU) accession in very difficult transitional environments like those of Croatia and Albania. Croatia, a post-socialist and a post-conflict state, and Albania, heavily burdened with the consequences of its recent isolationist history (which is unprecedented among other post-socialist states), were intentionally selected for this research as atypical cases. Acknowledging the lack of consensus about the Europeanization phenomena in the academic community, the authors decided to rely on indicators that focus not only on institution-building and policy-making processes in the technical sense, but also in the processes of construction and diffusion of formal and informal rules, procedures, styles and shared beliefs, norms and identities that are being transmitted from the European to the national level.
Based on qualitative research comparing the two countries – that is, Albania and Croatia – and using a number of indicators, the authors conclude that while Europeanization is an important part of European politics in general and the EU accession process in particular, it does not result in having a uniform impact on different candidate countries. On the contrary, the pace of integration depends on the specific domestic political context, on the role of the institutions, and on the processes of adaptation to the European political environment.
Typification of names in the genus Duranta (Duranteae, Verbenaceae)
Authors: PABLO MORONI , NATALY O’LEARY 
Published: June 2016

During the taxonomic revision of the genus Duranta, seventeen names were identified to need typification. All related herbaria and different literature concerning each name were studied. As a result twelve lectotypes, one epitype and four neotypes are designated here, which will contribute to stabilize the nomenclatural framework of the genus. Notes about typifications are provided.
Prediction of Sea Surface Temperature by Combining Numerical and Neural Techniques
Authors: Patil Kalpesh , Deo M. C. , Ravichandran M. 
Published: June 2016

AbstractThe prediction of sea surface temperature (SST) in real-time or online mode has applications in planning marine operations and forecasting climate. This paper demonstrates how SST measurements can be combined with numerical estimations with the help of neural networks and how reliable site-specific forecasts can be made accordingly. Additionally, this work demonstrates the skill of a special wavelet neural network in this task. The study was conducted at six different locations in the Indian Ocean and over three time scales (daily, weekly, and monthly). At every time step, the difference between the numerical estimation and the SST measurement was evaluated, an error time series was formed, and errors over future time steps were forecasted. The time series forecasting was affected through neural networks. The predicted errors were added to the numerical estimation, and SST predictions were made over five time steps in the future. The performance of this procedure was assessed through various error statistics, which showed a highly satisfactory functioning of this scheme. The wavelet neural network based on the particular basic or mother wavelet called the “Meyer wavelet with discrete approximation” worked more satisfactorily than other wavelets.
ACS NSQIP Risk Calculator
Authors: Prasad Kumar G. , Nelson Benton G. , Deig Christopher R. , Schneider Alexander L. , Moore Michael G. 
Published: June 2016

The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) calculator is meant to provide an estimation of perioperative risk. Our goal was to determine the clinical applicability of the calculator in major head and neck surgery. A retrospective chart review was completed for major head and neck operations performed at 1 institution from 2013 to 2014. The calculated perioperative complication risks from the ACS NSQIP calculator were compared with observed complication rates. Overall, the ACS NSQIP calculator had little predictive value for pneumonia, surgical site infection, 30‐day return to operating room, or length of stay within this cohort (P >. 05). The calculator appears to have some value predicting total numbers of complications but has poor performance predicting an individual’s risk of suffering a perioperative complication. In conclusion, in our small cohort of patients, the ACS NSQIP calculator was a poor predictor of perioperative complications following major head and neck operations.
eWOM: Extant Research Review and Future Research Avenues
Authors: Mishra Anubhav , Satish S M 
Published: June 2016

Executive Summary Word-of-mouth (WOM) communication is widely accepted as a critical factor in building marketing strategies and communications. Invention of the Internet and proliferation of social media have added a new electronic dimension to traditional WOM, thereby converting it into electronicWOM (eWOM). The extant literature has focused on various aspects of eWOM such as its effect on consumer’s purchase decision process, utilization of eWOM to build brand strength and consumer loyalty, information diffusion, and creating buzz among potential consumers. The purpose of this study is to do a systematic review and meet the two objectives: (1) summarize the extant literature in eWOM domain and (2) identify a few areas for future research. This article has been organized as follows. It starts with the definition and interrelationship between three keywords used in literature, which are traditional word-of-mouth (WOM), electronic word-of-mouth (eWOM, also referred as online word-of-mouth [OWOM]), and viral marketing. The article focuses on theoretical foundations and frameworks which form the basis of eWOM in the literature. eWOM borrows its foundation from different disciplines based on the research perspective. It highlights theories based on social perspective (sociology literature), information perspective (IS literature), and marketing perspective (specific theories from marketing literature). It identifies the motivational factors for consumer involvement in eWOM creation and diffusion process and summarizes the findings of literature on what drives consumer to spread eWOM on various channels. It discusses the findings from literature review on importance and effects of eWOM for marketing communications and marketing strategies. It provides actionable strategies for practitioners and marketers to suggest how they can utilize eWOM to improve performance, generate more sales and to communicate with consumers? It also looks at how to deal with negative eWOM and how a firm should respond to it. Finally, it analyses the current status of research and suggests a few areas for future researchers.
From Clozapine to Cognitive Remediation
Authors: Quinn Jason , Kolla Nathan J. 
Published: June 2016

Objective: Although a minority of persons with schizophrenia (SCZ) commits violent acts, SCZ remains a risk factor for violence. Here, we present a broad overview of evidence-based treatments for violence in SCZ, including biological and psychosocial interventions. Method: We conducted MEDLINE and PsychINFO literature searches to retrieve articles relating to treatments for violent, hostile, or aggressive behaviours in SCZ. Results: Clozapine shows the strongest evidence for treating the acute violence of SCZ. Other atypical antipsychotics also possess antiaggressive effects, although the evidence is not as robust as that for clozapine. Psychosocial treatments can be useful adjuncts to pharmacotherapy once patients’ positive symptoms have stabilized. Cognitive behavioural therapy for psychosis and cognitive remediation are 2 psychosocial interventions that have demonstrated positive outcomes for violence in SCZ. Most psychosocial studies that examined violence as an outcome were conducted in forensic psychiatric settings. Conclusions: Effective treatments exist for persons with SCZ who pose a risk for violent and aggressive behaviour, although the overall evidence base remains relatively weak. More randomized controlled trials of programs showing evidence for reduction of violence in SCZ are required. Further research should delineate which patients could benefit from multimodal treatment and where and when such treatments are optimally delivered.