bluuebunny/crossref_metadata_2025_split huggingface dataset:
Italian physicians’ contribution to geosciences
Authors: Pantaloni Marco , Console Fabiana , Lorusso Lorenzo , Petti Fabio Massimo , Franchini Antonia Francesca , Porro Alessandro , Romano Marco 
Published: March 2017

Abstract
Italian physicians have been interested in geology since the fifteenth century or earlier, with leading figures carrying out fundamental and enlightening studies in both fields of competence. Refined cultured men including Bernardino Ramazzini, Antonio Vallisneri, Tommaso Antonio Catullo, Carlo Gemmellaro, Leopoldo Pilla, Giuseppe Meneghini, Gaetano Giorgio Gemmellaro and Arcangelo Scacchi, in addition to the introduction of reasoning and basic concepts for the advancement of Earth sciences, conducted major studies in the medical field, proving once again the holistic interests of Italian intellectuals.

Following the publication of
Principles of Geology
by Charles Lyell, some scientists were fascinated by the geosciences, carrying out both medical observations and geological studies, and contributing significantly to the development of modern geology. The biographies and works of some leading Italian physicians illustrate their scientific activity in the study of stratigraphy, geomorphology, palaeontology and volcanology, with acknowledgement internationally. These Italian scientists contributed to the political unification of Italy, actively participating in scientific and political discussion, and fulfilling government aims. They contributed to the foundation of the Geological Society of Italy, one of the oldest scientific fellowships in Italy.
Effects of dobutamine on intestinal microvascular blood flow heterogeneity and O2 extraction during septic shock
Authors: Ospina-Tascón Gustavo A. , García Marin Alberto F. , Echeverri Gabriel J. , Bermudez William F. , Madriñán-Navia Humberto , Valencia Juan David , Quiñones Edgardo , Rodríguez Fernando , Marulanda Angela , Arango-Dávila César A. , Bruhn Alejandro , Hernández Glenn , De Backer Daniel 
Published: March 2017

Derangements of microvascular blood flow distribution might contribute to disturbing O2 extraction by peripheral tissues. We evaluated the dynamic relationships between the mesenteric O2 extraction ratio ([Formula: see text]) and the heterogeneity of microvascular blood flow at the gut and sublingual mucosa during the development and resuscitation of septic shock in a swine model of fecal peritonitis. Jejunal-villi and sublingual microcirculation were evaluated using a portable intravital-microscopy technique. Simultaneously, we obtained arterial, mixed-venous, and mesenteric blood gases, and jejunal-tonometric measurements. During resuscitation, pigs were randomly allocated to a fixed dose of dobutamine (5 µg·kg−1·min−1) or placebo while three sham models with identical monitoring served as controls. At the time of shock, we observed a significant decreased proportion of perfused intestinal-villi (villi-PPV) and sublingual percentage of perfused small vessels (SL-PPV), paralleling an increase in [Formula: see text] in both dobutamine and placebo groups. After starting resuscitation, villi-PPV and SL-PPV significantly increased in the dobutamine group with subsequent improvement of functional capillary density, whereas [Formula: see text] exhibited a corresponding significant decrease (repeated-measures ANOVA, P = 0.02 and P = 0.04 for time × group interactions and intergroup differences for villi-PPV and [Formula: see text], respectively). Variations in villi-PPV were paralleled by variations in [Formula: see text] ( R2 = 0.88, P < 0.001) and these, in turn, by mesenteric lactate changes ( R2 = 0.86, P < 0.001). There were no significant differences in cardiac output and systemic O2 delivery throughout the experiment. In conclusion, dynamic changes in microvascular blood flow heterogeneity at jejunal mucosa are closely related to the mesenteric O2 extraction ratio, suggesting a crucial role for microvascular blood flow distribution on O2 uptake during development and resuscitation from septic shock. NEW & NOTEWORTHY Our observations suggest that dynamic changes in the heterogeneity of microvascular blood flow at the gut mucosa are closely related to mesenteric O2 extraction, thus supporting the role of decreasing functional capillary density and increased intercapillary distances on alterations of O2 uptake during development and resuscitation from septic shock. Addition of a low-fixed dose of dobutamine might reverse such flow heterogeneity, improving microcirculatory flow distribution and tissue O2 consumption.
Achieving Precision Death with Cell-Cycle Inhibitors that Target DNA Replication and Repair
Authors: Lin Aimee Bence , McNeely Samuel C. , Beckmann Richard P. 
Published: March 2017

Abstract
All cancers are characterized by defects in the systems that ensure strict control of the cell cycle in normal tissues. The consequent excess tissue growth can be countered by drugs that halt cell division, and, indeed, the majority of chemotherapeutics developed during the last century work by disrupting processes essential for the cell cycle, particularly DNA synthesis, DNA replication, and chromatid segregation. In certain contexts, the efficacy of these classes of drugs can be impressive, but because they indiscriminately block the cell cycle of all actively dividing cells, their side effects severely constrain the dose and duration with which they can be administered, allowing both normal and malignant cells to escape complete growth arrest. Recent progress in understanding how cancers lose control of the cell cycle, coupled with comprehensive genomic profiling of human tumor biopsies, has shown that many cancers have mutations affecting various regulators and checkpoints that impinge on the core cell-cycle machinery. These defects introduce unique vulnerabilities that can be exploited by a next generation of drugs that promise improved therapeutic windows in patients whose tumors bear particular genomic aberrations, permitting increased dose intensity and efficacy. These developments, coupled with the success of new drugs targeting cell-cycle regulators, have led to a resurgence of interest in cell-cycle inhibitors. This review in particular focuses on the newer strategies that may facilitate better therapeutic targeting of drugs that inhibit the various components that safeguard the fidelity of the fundamental processes of DNA replication and repair. Clin Cancer Res; 23(13); 3232–40. ©2017 AACR.
Biological effects of ticagrelor over clopidogrel in patients with stable coronary artery disease and chronic obstructive pulmonary disease
Authors: Campo Gianluca , Dalla Sega Francesco Vieceli , Pavasini Rita , Aquila Giorgio , Gallo Francesco , Fortini Francesca , Tonet Elisabetta , Cimaglia Paolo , Del Franco Annamaria , Pestelli Gabriele , Pecoraro Alessandro , Contoli Marco , Balla Cristina , Biscaglia Simone , Rizzo Paola , Ferrari Roberto 
Published: March 2017

SummaryPatients with SCAD and concomitant COPD are at high risk of cardiovascular adverse events, due to chronic inflammation, responsible of endothelial dysfunction, oxidative stress and heightened platelet reactivity (PR). The objective of this randomised clinical trial was to test if ticagrelor is superior to clopidogrel in improving endothelial function in patients with stable coronary artery disease (SCAD) and concomitant chronic obstructive pulmonary disease (COPD). Forty-six patients with SCAD and COPD undergoing percutaneous coronary intervention (PCI) were randomly assigned to receive clopidogrel (n=23) or ticagrelor (n=23) on top of standard therapy with aspirin. The following parameters were assessed at baseline and after 1 month: i) rate of apoptosis and ii) nitric oxide (NO) levels in human umbilical vein endothelial cells (HUVECs), iii) levels of reactive oxygen species (ROS) in peripheral blood mononuclear cell, iv) 29 cytokines/chemokines, v) on-treatment PR. The primary endpoint of the study was the 1-month rate of HUVECs apoptosis. The rate of apoptosis after 1 month was significantly lower in patients treated with ticagrelor (7.4 ± 1.3% vs 9.3 ± 1.5%, p<0.001), satisfying the pre-specified primary endpoint. In the ticagrelor arm, levels of NO were higher (10.1 ± 2.2 AU vs 8.5 ± 2.6 AU, p=0.03) while those of ROS (4 ± 1.8 AU vs 5.7 ± 2.8 AU, p=0.02) and P2Y12 reactivity units (52 ± 70 PRU vs 155 ± 62 PRU, p<0.001) were lower. There were no differences in cytokines/chemokines levels and aspirin reactivity units between groups. In patients with SCAD and COPD undergoing PCI, ticagrelor, as compared to clopidogrel is superior in improving surrogate markers of endothelial function and on-treatment PR (ClinicalTrials.gov, NCT02519608).Supplementary Material to this article is available online at www.thrombosis-online.com.
ОСОБЛИВОСТІ ВЕРБАЛЬНОГО СПІЛКУВАННЯ МЕДИЧНОГО ПРАЦІВНИКА І ХВОРОГО
Authors: Medynska A. V. , Konovalenko S. O. 
Published: March 2017

У статті проаналізованo особливості функціонування мовного етикету та культури у професійній діяльності медичного працівника. Дані дослідження дають багатий матеріал для глибшого й повнішого опису сучасного стану функціонування мови у суспільстві в цілому, і зокрема у медичному колективі.
АЛКОГОЛІЗМ У ПІДЛІТКІВ ЯК ВАЖЛИВА МЕДИКО-СОЦІАЛЬНА ПРОБЛЕМА
Authors: Lysyuk I. V. 
Published: March 2017

У статті проаналізовано основні чинники розвитку підліткового алкоголізму в Україні та розроблено систему педагогічних заходів з метою психологічної профілактики вживання алкоголю серед молоді, які рекомендується використовувати в роботі кураторів студентських груп.
Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium–Sensing Receptor
Authors: Xiao Rui , Su Yuan , Feng Tian , Sun Mengxiang , Liu Bingxun , Zhang Jiwei , Lu Yankai , Li Jiansha , Wang Tao , Zhu Liping , Hu Qinghua 
Published: March 2017

Background
Monocrotaline has been widely used to establish an animal model of pulmonary hypertension. The molecular target underlying monocrotaline‐induced pulmonary artery endothelial injury and pulmonary hypertension remains unknown. The extracellular calcium–sensing receptor (CaSR) and particularly its extracellular domain hold the potential structural basis for monocrotaline to bind. This study aimed to reveal whether monocrotaline induces pulmonary hypertension by targeting the CaSR.

Methods and Results

Nuclear magnetic resonance screening through Water
LOGSY
(water ligand‐observed gradient spectroscopy) and saturation transfer difference on protein preparation demonstrated the binding of monocrotaline to the CaSR. Immunocytochemical staining showed colocalization of monocrotaline with the CaSR in cultured pulmonary artery endothelial cells. Cellular thermal shift assay further verified the binding of monocrotaline to the CaSR in pulmonary arteries from monocrotaline‐injected rats. Monocrotaline enhanced the assembly of CaSR, triggered the mobilization of calcium signaling, and damaged pulmonary artery endothelial cells in a CaSR‐dependent manner. Finally, monocrotaline‐induced pulmonary hypertension in rats was significantly attenuated or abolished by the inhibitor, the general or lung knockdown or knockout of CaSR.

Conclusions
Monocrotaline aggregates on and activates the CaSR of pulmonary artery endothelial cells to trigger endothelial damage and, ultimately, induces pulmonary hypertension.
Climate Process Team on Internal Wave–Driven Ocean Mixing
Authors: MacKinnon Jennifer A. , Zhao Zhongxiang , Whalen Caitlin B. , Waterhouse Amy F. , Trossman David S. , Sun Oliver M. , St. Laurent Louis C. , Simmons Harper L. , Polzin Kurt , Pinkel Robert , Pickering Andrew , Norton Nancy J. , Nash Jonathan D. , Musgrave Ruth , Merchant Lynne M. , Melet Angelique V. , Mater Benjamin , Legg Sonya , Large William G. , Kunze Eric , Klymak Jody M. , Jochum Markus , Jayne Steven R. , Hallberg Robert W. , Griffies Stephen M. , Diggs Steve , Danabasoglu Gokhan , Chassignet Eric P. , Buijsman Maarten C. , Bryan Frank O. , Briegleb Bruce P. , Barna Andrew , Arbic Brian K. , Ansong Joseph K. , Alford Matthew H. 
Published: March 2017

AbstractDiapycnal mixing plays a primary role in the thermodynamic balance of the ocean and, consequently, in oceanic heat and carbon uptake and storage. Though observed mixing rates are on average consistent with values required by inverse models, recent attention has focused on the dramatic spatial variability, spanning several orders of magnitude, of mixing rates in both the upper and deep ocean. Away from ocean boundaries, the spatiotemporal patterns of mixing are largely driven by the geography of generation, propagation, and dissipation of internal waves, which supply much of the power for turbulent mixing. Over the last 5 years and under the auspices of U.S. Climate Variability and Predictability Program (CLIVAR), a National Science Foundation (NSF)- and National Oceanic and Atmospheric Administration (NOAA)-supported Climate Process Team has been engaged in developing, implementing, and testing dynamics-based parameterizations for internal wave–driven turbulent mixing in global ocean models. The work has primarily focused on turbulence 1) near sites of internal tide generation, 2) in the upper ocean related to wind-generated near inertial motions, 3) due to internal lee waves generated by low-frequency mesoscale flows over topography, and 4) at ocean margins. Here, we review recent progress, describe the tools developed, and discuss future directions.
Generating Probabilistic Forecasts from Convection-Allowing Ensembles Using Neighborhood Approaches: A Review and Recommendations
Authors: Schwartz Craig S. , Sobash Ryan A. 
Published: March 2017

Abstract“Neighborhood approaches” have been used in two primary ways to postprocess and verify high-resolution ensemble output. While the two methods appear deceptively similar, they define events over different spatial scales and yield fields with different interpretations: the first produces probabilities interpreted as likelihood of event occurrence at the grid scale, while the second produces probabilities of event occurrence over spatial scales larger than the grid scale. Unfortunately, some studies have confused the two methods, while others did not acknowledge multiple possibilities of neighborhood approach application and simply stated, “a neighborhood approach was applied” without supporting details. Thus, this paper reviews applications of neighborhood approaches to convection-allowing ensembles in hopes of clarifying the two methods and their different event definitions. Then, using real data, it is demonstrated how the two approaches can yield statistically significantly different objective conclusions about model performance, underscoring the critical need for thorough descriptions of how neighborhood approaches are implemented and events are defined. The authors conclude by providing some recommendations for application of neighborhood approaches to convection-allowing ensembles.
Negative Life Events, Social Support, and Self-Efficacy in Anxious Adolescents
Authors: Raknes Solfrid , Pallesen Ståle , Bjaastad Jon Fauskanger , Wergeland Gro Janne , Hoffart Asle , Dyregrov Kari , Håland Åshild Tellefsen , Haugland Bente Storm Mowatt 
Published: March 2017

Purpose To examine the prevalence and correlates of anxiety in a community sample of adolescents. Knowing the prevalence and characteristics of anxious adolescents is valuable to improve anxiety prevention strategies and interventions. Design Cross-sectional data about anxiety were collected via a school survey from a community sample of Norwegian adolescents aged 12–17 ( N = 1719). Methods Based on scores from the Spence Children’s Anxiety Scale, the adolescents were categorized as not anxious or anxious. Logistic regression analysis was performed to access the impact of each factor on the likelihood that participants would report an elevated level of anxiety. Results A total of 22% of the adolescents were categorized as anxious. Female gender, experienced negative life events, low social support, and low self-efficacy were associated with elevated level of anxiety. Conclusions The high prevalence of anxiety in adolescents demonstrates the importance of improved prevention interventions targeting anxious adolescents. We argue that addressing is the responsibility of not only the individual adolescents and their families but also schools, school health services, and policy makers. School-based interventions that increase social support and self-efficacy would probably be particularly beneficial for anxious adolescents.
Critical Value of Anterior Glenoid Bone Loss That Leads to Recurrent Glenohumeral Instability After Arthroscopic Bankart Repair
Authors: Shin Sang-Jin , Kim Rag Gyu , Jeon Yoon Sang , Kwon Tae Hun 
Published: March 2017

Background: Generally, a glenoid bone loss greater than 20% to 25% is considered critical for poor surgical outcomes after a soft tissue repair. However, recent studies have suggested that the critical value should be lower. Purpose: To determine the critical value of anterior glenoid bone loss that led to surgical failure in patients with anterior shoulder instability. Study Design: Case-control study; Level of evidence, 3. Methods: The study included 169 patients with anterior glenoid erosion. The percentage of glenoid erosion was calculated as the ratio of the glenoid loss width and the glenoid width to the diameter of the outer-fitting circle based on the inferior portion of the glenoid contour. The critical value of the glenoid bone loss was analyzed by means of receiver operating characteristic (ROC) curve analysis. Patients were divided into 2 groups based on the amount of glenoid bone loss: group A (less than the critical value) and group B (more than the critical value). Patients evaluated their shoulder function as a percentage of their preinjury level using the Single Assessment Numeric Evaluation (SANE) score, and postoperative clinical outcomes were assessed with the American Shoulder and Elbow Surgeons (ASES) score and Rowe score. Surgical failure was defined as the need for revision surgery or the presence of subjective symptoms of instability. Results: The optimal critical value of glenoid bone loss was 17.3% (area under the curve = 0.82; 95% confidence interval, 0.73-0.91; P < .001; sensitivity 75%; specificity 86.6%). Group A and B contained 134 and 35 patients, respectively. Shoulder functional scores were significantly lower in group B than in group A ( P < .001). Five patients (3.7%) in group A and 15 (42.9%) in group B had surgical failure ( P < .001). The SANE score was significantly lower in group B (83.8 ± 12.1) than in group A (92.9 ± 4.7, P = .001). Conclusion: An anterior glenoid bone loss of 17.3% or more with respect to the longest anteroposterior glenoid width should be considered as the critical amount of bone loss that may result in recurrent glenohumeral instability after arthroscopic Bankart repair.
Child Abuse Experiences and Perceived Need for Care and Mental Health Service Use among Members of the Canadian Armed Forces
Authors: Turner Sarah , Taillieu Tamara , Cheung Kristene , Zamorski Mark , Boulos David , Sareen Jitender , Afifi Tracie O. 
Published: March 2017

Objective: Child abuse is associated with poor mental health outcomes in adulthood. However, little is known about how a history of child abuse may be related to perceived need for care (PNC) and mental health service use (MHSU) among Canadian military personnel. The objectives of this study were to determine 1) the relationship between child abuse history and PNC and 2) the relationship between child abuse history and MHSU in the Canadian military. Method: Data were drawn from the 2013 Canadian Forces Mental Health Survey ( n = 6692 Regular Force personnel between the ages of 18 and 60 years). Logistic regression was used to examine the relationships between individual child abuse types and PNC and MHSU while adjusting for sociodemographic variables, the presence of mental disorders, deployment-related variables, and other types of child abuse. Population attributable fractions (PAFs) were calculated to estimate the proportion of PNC and MHSU that may be attributable to child abuse. Results: Each individual child abuse type was associated with increased odds of PNC and MHSU after adjusting for all covariates (adjusted odds ratio ranging from 1.26 to 1.80). PAFs showed that if any child abuse did not occur, PNC and MHSU among Regular Force personnel may be reduced by approximately 14.3% and 11.3%, respectively. Conclusions: This study highlights that preenlistment factors, such as a history of child abuse, have an independent association with PNC and MHSU and hence need to be considered when assessing the mental health service needs of the Canadian Regular Force personnel.
Pleuropulmonary involvement in patients with systemic lupus erythematosus from a Latin American inception cohort (GLADEL)
Authors: Haye Salinas M J , Caeiro F , Saurit V , Alvarellos A , Wojdyla D , Scherbarth H R , de O e Silva A C , Tavares Brenol J C , Lavras Costallat L T , Neira O J , Iglesias Gamarra A , Vásquez G , Reyes Llerena G A , Barile-Fabris L A , Silveira L H , Sauza del Pozo M J , Acevedo Vásquez E M , Alfaro Lozano J L , Esteva Spinetti M H , Alarcón G S , Pons-Estel B A 
Published: March 2017

Objectives The objectives of this study were to examine the demographic and clinical features associated with the occurrence of pleuropulmonary manifestations, the predictive factors of their occurrence and their impact on mortality in systemic lupus erythematosus (SLE) patients. Materials and methods The association of pleuropulmonary manifestations with demographic and clinical features, the predictive factors of their occurrence and their impact on mortality were examined in GLADEL patients by appropriate univariable and multivariable analyses. Results At least one pleuropulmonary manifestation occurred in 421 of the 1480 SLE patients (28.4%), pleurisy being the most frequent (24.0%). Age at SLE onset ≥30 years (OR 1.42; 95% CI 1.10–1.83), the presence of lower respiratory tract infection (OR 3.19; 95% CI 2.05–4.96), non-ischemic heart disease (OR 3.17; 95% CI 2.41–4.18), ischemic heart disease (OR 3.39; 95% CI 2.08–5.54), systemic (OR 2.00; 95% CI 1.37–2.91), ocular (OR 1.58; 95% CI 1.16–2.14) and renal manifestations (OR 1.44; 95% CI 1.09–1.83) were associated with pleuropulmonary manifestations, whereas cutaneous manifestations were negatively associated (OR 0.47; 95% CI 0.29–0.76). Non-ischemic heart disease (HR 2.24; 95% CI 1.63–3.09), SDI scores ≥1 (OR 1.54; 95% CI 1.10–2.17) and anti-La antibody positivity (OR 2.51; 95% CI 1.39–4.57) independently predicted their subsequent occurrence. Cutaneous manifestations were protective of the subsequent occurrence of pleuropulmonary manifestations (HR 0.62; 95% CI 0.43–0.90). Pleuropulmonary manifestations independently contributed a decreased survival (HR: 2.79 95% CI 1.80–4.31). Conclusion Pleuropulmonary manifestations are frequent in SLE, particularly pleuritis. Older age, respiratory tract infection, cardiac, systemic and renal involvement were associated with them, whereas cutaneous manifestations were negatively associated. Cardiac compromise, SDI scores ≥1 and anti-La positivity at disease onset were predictive of their subsequent occurrence, whereas cutaneous manifestations were protective. They independently contributed to a decreased survival in these patients.