bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indigenous entrepreneurship in Aotearoa New Zealand
Authors: Kawharu Merata , Tapsell Paul , Woods Christine 
Published: June 2017

Purpose
Exploring the links between resilience, sustainability and entrepreneurship from an indigenous perspective means exploring the historic and socio-cultural context out of which a community originates. From this perspective, informed insight into a community’s ability to adapt and to transform without major structural collapse when confronted with exogenous challenges or crises can be gained. This paper explores the interplay between resilience and entrepreneurship in a New Zealand indigenous setting.

Design/methodology/approach
The authors provide a theoretical and case study approach, exploring four intersecting leadership roles, their guiding value system and application at a micro kin family level through a tourism venture and at a macro kin tribal level through an urban land development venture.

Findings
The findings demonstrate the importance of historical precedent and socio-cultural values in shaping the leadership matrix that addresses exogenous challenges and crises in an entrepreneurship context.

Research limitations/implications
The research is limited to New Zealand, but the findings have synergies with other indigenous entrepreneurship elsewhere. Further cross-cultural research in this field includes examining the interplay between rights and duties within indigenous communities as contributing facets to indigenous resilience and entrepreneurship.

Originality/value
This research is a contribution to theory and to indigenous community entrepreneurship in demonstrating what values and behaviours are assistive in confronting shocks, crises and challenges. Its originality is in the multi-disciplinary approach, combining economic and social anthropological, indigenous and non-indigenous perspectives. The originality of this paper also includes an analysis of contexts that appear to fall outside contemporary entrepreneurship, but are in fact directly linked.
Which came first, the chicken or the egg?
Authors: McInnis-Bowers Cecilia , Parris Denise Linda , Galperin Bella L. 
Published: June 2017

PurposeThis paper aims to explore the relationship between entrepreneurship and resilience in an indigenous context. The overarching research questions are: What are the mechanisms that link entrepreneurial thought and action to resilience in a marginalized context? How can entrepreneurial thought and actions lead to building economic, community and cultural resilience?Design/methodology/approachAn exploratory-naturalistic case study methodology was used to examine the entrepreneurial journey of the Boruca. Data were collected from in-depth semi-structured and unstructured interviews among 10 informants over a five-year period. Constant comparative method was used to analyze the data.FindingsDue to the need to survive, the Boruca engaged in entrepreneurial thought and action, which, in turn, led to the development of community, cultural and economic resilience. The authors developed a conceptual model to illustrate how individual resiliency gained through entrepreneurial thought and action led to community, cultural and economic resiliency of the Boruca.Research limitations/implicationsThis paper examines the entrepreneurial journey of one of the eight indigenous tribes of Costa Rica. Future research should expand their sample to include the other indigenous contexts.Practical implicationsFrom a practical standpoint, this paper suggests the need for entrepreneurial training among indigenous businesses as a key factor in developing resiliency. This is applicable for non-profit, for-profit and public organizations interested in preserving world ethnic cultures and empowering indigenous people.Social implicationsGaining deeper and richer insights into the linkages of resilience and entrepreneurial success is important for supporting efforts of those seeking to forge pathways out of poverty.Originality/valueThis paper suggests a different view of the relationship between resilience and entrepreneurship when the context is outside of the resource-rich context of the developed world.
Using Administrative Data for Research on Homelessness: Applying a US Framework to Australia
Authors: Metraux Stephen , Tseng Yi‐Ping 
Published: June 2017

AbstractThe past decade has seen increased use in Australia in the use of administrative data in homelessness research. We review this research, using a framework from the US literature, and highlight innovative and policy‐relevant Australian initiatives in five areas. While the use of administrative data in Australian research on homelessness has lagged behind what has been done in the United States, the emerging body of Australian research in this area should continue to take an increased role in understanding and informing responses to homelessness. We conclude by assessing the opportunities and challenges facing continued research using this type of data.
Empirical Research: Getting Started with Stata
Authors: Tiong Daniel 
Published: June 2017

AbstractThis article provides a guide to approaching empirical research work for the first time, as well as obtaining a foundation in the use of the statistical software package, Stata. The emphasis revolves around data cleaning and its importance in writing a good research essay. I also cover a basic introduction to Stata, the importance of do‐files, common data problems and good coding practice. In closing, I advise that not everything in research needs to go to plan, but that good research practice makes it easier to adapt when plans do not work out.
Sudden Death by Spontaneous Epiglottic Hematoma Secondary to High Blood Levels of Warfarin
Authors: Gilard‐Pioc Séverine , Guerard Pascal , Paraf François , François‐Purssell Irène 
Published: June 2017

AbstractA 67‐year‐old man was found dead, at his home. On external examination, we found a voluminous purplish black ecchymosis of the anterior neck area. On internal examination, we found a voluminous epiglottis hematoma completely obstructing the upper airway. It was associated with other sites of intra‐abdominal hemorrhage. Toxicological studies revealed the presence of warfarin at a concentration of 8.4 mg/L in peripheral blood, which supposes an INR well above 4.5. To conclude, we supposed death was due to asphyxia secondary to a spontaneous epiglottic hematoma caused by a high blood concentration of warfarin. Hemorrhage in the epiglottis is very rare. To our knowledge, our patient is the only case of “sudden death” reported with spontaneous epiglottic hematoma due to high blood concentration of warfarin. In forensic practice, an anterior neck ecchymosis, without trauma, may suggest hemorrhage into soft airway tissues. Pathology findings make it possible to exclude exogenous trauma.
The use of selective progestin receptor modulators (SPRMs) and more specifically ulipristal acetate in the practice of gynaecology
Authors: Rozenberg Serge , Praet Julie , Pazzaglia Eliza , Gilles Christine , Manigart Yannick , Vandromme Jean 
Published: June 2017

This review discusses the development of selective progestin receptor modulators (SPRMs) for use in women's health and specifically the use of ulipristal acetate (UPA) as emergency contraception (EC) and as a treatment for symptomatic fibroids in women who want to preserve their fertility or avoid a hysterectomy. As an EC, UPA 30 mg should be recommended for women, within 102 h of unprotected intercourse. As a treatment of fibroids, UPA (5 mg daily dose) should be administered for periods of three months as a pre‐surgical strategy, reducing bleeding and fibroid size and facilitating surgery. A proportion of these patients may even avoid surgery. Future developments will demonstrate whether UPA can be used for other indications such as endometriosis and breast cancer prevention or treatment.
Effect of soybean husk supplementation on the fecal fermentation metabolites and microbiota of dogs
Authors: Myint Htun , Iwahashi Yu , Koike Satoshi , Kobayashi Yasuo 
Published: June 2017

AbstractIn vitro fermentation and in vivo feeding experiments were conducted to characterize the effects of soybean (Glycine max) husk on the fecal fermentation metabolites and microbiota of dogs. An in vitro fermentation study using feces from three Toy Poodle dogs (6.5 ± 3.5 months in age and 2.9 ± 0.4 kg in body weight) revealed that the fecal inoculum was able to ferment soybean husk (supplemented at 0.01 g/mL culture) and increased levels of short chain fatty acids (SCFA) and Bifidobacterium, irrespective of pre‐digestion of the husk by pepsin and pancreatin. In a feeding experiment, four Shiba dogs (7–48 months in age and 7.5 ± 1.7 kg in body weight) fed a commercial diet supplemented with 5.6% soybean husk showed an increase in SCFA, such as acetate and butyrate, and lactate, and a decrease in indole and skatole in the feces compared to those fed a 5.6% cellulose diet. Real‐time PCR assay showed that soybean husk supplementation stimulated the growth of lactobacilli, Clostridium cluster IV including Faecalibacterium prausnitzii, Clostridium cluster XIVa, Bacteroides‐Prevotella‐Porphyromonas group but inhibited the growth of Clostridium cluster XI. Both in vitro and in vivo experiments indicated that soybean husk supplementation improves gastrointestinal health through optimization of beneficial organic acid production and increase of beneficial bacteria. Therefore, soybean husk is suggested to be applicable as a functional fiber in the formulation of canine diets.
Conducting research in clinical psychology practice: Barriers, facilitators, and recommendations
Authors: Smith Kirsten V. , Thew Graham R. 
Published: June 2017

ObjectivesThe combination of clinical psychologists’ therapeutic expertise and research training means that they are in an ideal position to be conducting high‐quality research projects. However, despite these skills and the documented benefits of research to services and service users, research activity in practice remains low. This article aims to give an overview of the advantages of, and difficulties in conducting research in clinical practice.MethodWe reviewed the relevant literature on barriers to research and reflected on our clinical and research experiences in a range of contexts to offer practical recommendations.ResultsWe considered factors involved in the planning, sourcing support, implementation, and dissemination phases of research, and outline suggestions to improve the feasibility of research projects in post‐qualification roles.ConclusionsWe suggest that research leadership is particularly important within clinical psychology to ensure the profession's continued visibility and influence within health settings.Practitioner points

Clinical implications

Emerging evidence suggests that clinical settings that foster research are associated with better patient outcomes.

Suggestions to increase the feasibility of research projects in clinical settings are detailed.

Limitations

The present recommendations are drawn from the authors’ practical experience and may need adaptation to individual practitioners’ settings.

This study does not attempt to assess the efficacy of the strategies suggested.
The Role of Speaker Knowledge in Children's Pragmatic Inferences
Authors: Papafragou Anna , Friedberg Carlyn , Cohen Matthew L. 
Published: June 2017

During communication, conversational partners should offer as much information as is required and relevant. For instance, the statement “Some Xs Y” is infelicitous if one knows that all Xs Y. Do children understand the link between speaker knowledge and utterance strength? In Experiment 1, 5‐year‐olds (N = 32) but not 4‐year‐olds (N = 32) reliably connected statements of different logical strength (e.g., “The girl colored all/some of the star”) to observers who were fully or partially informed. Four‐year‐olds’ performance improved when observer knowledge could be assessed more easily (Experiment 2a,N = 25) but remained the same in a nonlinguistic version of Experiment 1 that preserved the epistemic requirements of the original study (Experiment 2b,N = 26). These findings have implications for the development of early communicative abilities.
Role of contact force‐guided radiofrequency catheter ablation for treatment of atrial fibrillation: A systematic review and meta‐analysis
Authors: Lin Hui , Chen Yi‐He , Hou Jian‐Wen , Lu Zhao‐Yang , Xiang Yin , Li Yi‐Gang 
Published: June 2017

AbstractIntroductionCF‐sensing catheter emerged as a novel ablation technology and was increasingly used in clinical practice. Nonetheless, available evidence of efficacy and safety comparison between CF‐guided RF catheter ablation and non‐CF‐guided ablation for treatment of AF was still lacking.Methods and resultsTwenty‐two eligible studies were included after systematic review through the MEDLINE, Google Scholar, the Cochrane Library and PubMed databases. AF/atrial tachycardia‐free survival was markedly improved in CF‐guided catheter ablation compared with non‐CF‐guided ablation at a median 12‐month follow‐up (RR: 1.12, 95% CI: 1.06–1.19, P = 0.000, fixed). Notably, CF‐guided catheter ablation presented a robust survival benefit for treatment of paroxysmal AF (RR: 1.10, 95% CI: 1.03–1.18, P = 0.005, fixed), but not persistent AF (RR: 1.07, 95% CI: 0.89–1.28, P = 0.466, fixed). Moreover, procedure time (WMD: −23.87, 95% CI: −33.83 to −13.91, P = 0.000, random), fluoroscopy time (WMD: −7.78, 95% CI: −13.93 to −1.63, P = 0.013, random) and RF time (WMD: −3.98, 95% CI: −7.78 to −0.17, P = 0.040, random) were significantly reduced in CF‐guided catheter ablation. The incidence of procedure‐related complications did not differ between these two technologies (RR: 0.83, 95% CI: 0.59 to 1.16, P = 0.271, fixed).ConclusionCF‐guided RF catheter ablation was associated with a significant AF/atrial tachycardia‐free survival benefit compared with non‐CF‐guided ablation in patients with paroxysmal AF rather than persistent AF. In addition, CF‐guided ablation strategy also reduced the procedure time, fluoroscopy time, as well as RF time despite no distinct effect on the alleviation of procedure‐related complications.
ARE SHORT SELLERS INFORMED? EVIDENCE FROM CREDIT RATING AGENCY ANNOUNCEMENTS
Authors: Shi Jian , Wang Junbo , Zhang Ting 
Published: June 2017

AbstractAlthough constrained by rules and regulations, informed short selling (tipping) is present before negative credit watch and certain types of rating downgrade announcements. Using entity credit rating and daily short sale data from April 2004 to December 2009, we find that preannouncement abnormal short selling significantly increases toward the announcement dates and is negatively related to postannouncement stock returns. Furthermore, short selling driven by tipping is more pronounced before more severe and more surprising rating downgrades. This study provides evidence favoring the private information hypothesis (tipping) in the ongoing debate of the informational advantage of short sellers.
Critical Role for Monocytes/Macrophages in Rapid Progression to AIDS in Pediatric Simian Immunodeficiency Virus-Infected Rhesus Macaques
Authors: Sugimoto Chie , Merino Kristen M. , Hasegawa Atsuhiko , Wang Xiaolei , Alvarez Xavier A. , Wakao Hiroshi , Mori Kazuyasu , Kim Woong-Ki , Veazey Ronald S. , Didier Elizabeth S. , Kuroda Marcelo J. 
Published: June 2017

ABSTRACT

Infant humans and rhesus macaques infected with the human or simian immunodeficiency virus (HIV or SIV), respectively, express higher viral loads and progress more rapidly to AIDS than infected adults. Activated memory CD4
+
T cells in intestinal tissues are major primary target cells for SIV/HIV infection, and massive depletion of these cells is considered a major cause of immunodeficiency. Monocytes and macrophages are important cells of innate immunity and also are targets of HIV/SIV infection. We reported previously that a high peripheral blood monocyte turnover rate was predictive for the onset of disease progression to AIDS in SIV-infected adult macaques. The purpose of this study was to determine if earlier or higher infection of monocytes/macrophages contributes to the more rapid progression to AIDS in infants. We observed that uninfected infant rhesus macaques exhibited higher physiologic baseline monocyte turnover than adults. Early after SIV infection, the monocyte turnover further increased, and it remained high during progression to AIDS. A high percentage of terminal deoxynucleotidyltransferase dUTP nick end label (TUNEL)-positive macrophages in the lymph nodes (LNs) and intestine corresponded with an increasing number of macrophages derived from circulating monocytes (bromodeoxyuridine positive [BrdU
+
] CD163
+
), suggesting that the increased blood monocyte turnover was required to rapidly replenish destroyed tissue macrophages. Immunofluorescence analysis further demonstrated that macrophages were a significant portion of the virus-producing cells found in LNs, intestinal tissues, and lungs. The higher baseline monocyte turnover in infant macaques and subsequent macrophage damage by SIV infection may help explain the basis of more rapid disease progression to AIDS in infants.

IMPORTANCE
HIV infection progresses much more rapidly in pediatric cases than in adults; however, the mechanism for this difference is unclear. Using the rhesus macaque model, this work was performed to address why infants infected with SIV progress more quickly to AIDS than do adults. Earlier we reported that in adult rhesus macaques, increasing monocyte turnover reflected tissue macrophage damage by SIV and was predictive of terminal disease progression to AIDS. Here we report that uninfected infant rhesus macaques exhibited a higher physiological baseline monocyte turnover rate than adults. Furthermore, once infected with SIV, infants displayed further increased monocyte turnover that may have facilitated the accelerated progression to AIDS. These results support a role for monocytes and macrophages in the pathogenesis of SIV/HIV and begin to explain why infants are more prone to rapid disease progression.
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination
Authors: Jiang Hong , Rivera-Molina Yisel , Gomez-Manzano Candelaria , Clise-Dwyer Karen , Bover Laura , Vence Luis M. , Yuan Ying , Lang Frederick F. , Toniatti Carlo , Hossain Mohammad B. , Fueyo Juan 
Published: June 2017

AbstractOncolytic viruses selectively lyse tumor cells, disrupt immunosuppression within the tumor, and reactivate antitumor immunity, but they have yet to live up to their therapeutic potential. Immune checkpoint modulation has been efficacious in a variety of cancer with an immunogenic microenvironment, but is associated with toxicity due to nonspecific T-cell activation. Therefore, combining these two strategies would likely result in both effective and specific cancer therapy. To test the hypothesis, we first constructed oncolytic adenovirus Delta-24-RGDOX expressing the immune costimulator OX40 ligand (OX40L). Like its predecessor Delta-24-RGD, Delta-24-RGDOX induced immunogenic cell death and recruit lymphocytes to the tumor site. Compared with Delta-24-RGD, Delta-24-RGDOX exhibited superior tumor-specific activation of lymphocytes and proliferation of CD8+ T cells specific to tumor-associated antigens, resulting in cancer-specific immunity. Delta-24-RGDOX mediated more potent antiglioma activity in immunocompetent C57BL/6 but not immunodeficient athymic mice, leading to specific immune memory against the tumor. To further overcome the immune suppression mediated by programmed death-ligand 1 (PD-L1) expression on cancer cells accompanied with virotherapy, intratumoral injection of Delta-24-RGDOX and an anti-PD-L1 antibody showed synergistic inhibition of gliomas and significantly increased survival in mice. Our data demonstrate that combining an oncolytic virus with tumor-targeting immune checkpoint modulators elicits potent in situ autologous cancer vaccination, resulting in an efficacious, tumor-specific, and long-lasting therapeutic effect. Cancer Res; 77(14); 3894–907. ©2017 AACR.
Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation
Authors: Mojica Muñoz Ann-Katrin , Jamasbi Janina , Uhland Kerstin , Degen Heidrun , Münch Götz , Ungerer Martin , Brandl Richard , Megens Remco , Weber Christian , Lorenz Reinhard , Siess Wolfgang 
Published: June 2017

SummaryThe efficiency of current dual antiplatelet therapy might be further improved by its combination with a glycoprotein (GP) VI-targeting strategy without increasing bleeding. GPVI-Fc, a recombinant dimeric fusion protein binding to plaque collagen and concealing binding sites for platelet GPVI, acts as a lesion-focused antiplatelet drug, and does not increase bleeding in vivo. We investigated, whether GPVI-Fc added in vitro on top of acetylsalicylic acid (ASA), the P2Y12 antagonist ticagrelor, and the fibrinogen receptor antagonist abciximab alone or in combination would increase inhibition of platelet activation by atherosclerotic plaque. Under static conditions, GPVI-Fc inhibited plaque-induced platelet aggregation by 53%, and increased platelet inhibition by ASA (51%) and ticagrelor (64%) to 66% and 80%, respectively. Under arterial flow, GPVI-Fc inhibited plaque-induced platelet aggregation by 57%, and significantly increased platelet inhibition by ASA (28%) and ticagrelor (47%) to about 81% each. The triple combination of GPVI-Fc, ASA and ticagrelor achieved almost complete inhibition of plaque-induced platelet aggregation (93%). GPVI-Fc alone or in combination with ASA or ticagrelor did not increase closure time measured by the platelet function analyzer (PFA)-200. GPVI-Fc added on top of abciximab, a clinically used anti-fibrinogen receptor antibody which blocks platelet aggregation, strongly inhibited total (81%) and stable (89%) platelet adhesion. We conclude that GPVI-Fc added on top of single or dual antiplatelet therapy with ASA and/or a P2Y12 antagonist is likely to improve anti-atherothrombotic protection without increasing bleeding risk. In contrast, the strong inhibition of platelet adhesion by GPVI-Fc in combination with GPIIb/IIIa inhibitors could be harmful.Note: The review process for this manuscript was fully handled by Gregory Y. H. Lip, Editor in Chief.Supplementary Material to this article is available at www.thrombosis-online.com.
Field Data Analysis and Weather Scenario of a Downburst Event in Livorno, Italy, on 1 October 2012
Authors: Burlando Massimiliano , Romanić Djordje , Solari Giovanni , Hangan Horia , Zhang Shi 
Published: June 2017

AbstractThe Mediterranean is a “hot spot” for the genesis of different types of severe weather events, including potentially damaging wind phenomena like downbursts, whose occurrence and evolution in this geographical region have not been documented in the literature. This paper is part of an interdisciplinary collaboration between atmospheric scientists and wind engineers with the objective of conducting a comprehensive analysis of the field measurements and weather scenarios related to nonsynoptic wind systems in this area. The downburst that struck the Livorno coast of Italy at about 1310 local time 1 October 2012 is investigated as a relevant test case for such severe wind events. The wind velocity records detected by ultrasonic anemometers, part of a monitoring network created for the European “Wind and Ports” and “Wind, Ports and Sea” projects, are analyzed and decomposed in order to inspect the main statistical features of this transient event. The analysis of the meteorological precursors to this event is carried out making use of model analyses, standard in situ measurements, remote sensing techniques, proxy data, and direct observations. The results obtained bring new insights into a downburst’s onset and detection in the Mediterranean, its evolution at the local scale, and possible connections to specific synoptic-scale weather conditions like secondary cyclogenesis in the lee of the Alps.