bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biotype characterization of Staphylococcus aureus from milk and dairy products of private production in the western regions of Ukraine
Authors: Kukhtyn M. D. , Horyuk Y. V. , Horyuk V. V. , Yaroshenko T. Y. , Vichko O. I. , Pokotylo O. S. 
Published: September 2017

Prevention of foodborne diseases is a priority for the world health system. In the process of manufacturing milk and dairy products, the most important factor endangering their safety is seeding with a conditionally pathogenic and pathogenic microflora. Salmonella, Escherichia coli, Listeria and other microorganisms that reproduce in dairy products without changing their organoleptic properties are a particular danger. Staphylococcus aureus is an opportunistic, conditionally pathogenic microorganism that often contaminates raw milk and dairy products. The aim of the research presented in this article was to determine the dissemination of S. aureus in milk and milk products of household production in the western regions of Ukraine, to identify the biotypes of S. aureus, production of enterotoxins and the presence of methicillin-resistant strains. S. aureus was isolated on BD Baird-Parker Agar. The biotypes of S. aureus were determined according to Meer. The determination of MRSA was carried out on the chromogenic Agar chromID MRSA ("Biomerioux", Russia). The mecA gene was determined using the LightCycler MRSA Advanced Test with LightCycler 2.0 primer (Roche Molecular Biochemicals, Germany). To determine staphylococcal enterotoxins, the test system RIDASCREENSET A, B, C, D, E (R-Biopharm AG, Darmstadt, Germany) was used. We isolated saprophyte staphylococci from milk of raw and dairy products in western regions of Ukraine in 82.7–97.4% of samples. S. aureus is much more rarely isolated from these dairy products, so it was isolated from sour cream at 62.8 ± 0.9%, from milk at 35.5 ± 1.3% and cottage cheese at 23.0 ± 1.6%. Of the most well0known biotypes of S. aureus present in milk of raw and dairy products of domestic production, two ecological types were distinguished: human and cattle. In this case S. aureus var. hominis was isolated more often than in S. aureus var. bovis. This gives grounds to believe that the main source of contamination with milk staphylococci of raw and dairy products of domestic production is people. Enterotoxin type A, which causes foodborne toxemia, was produced by S. aureus in 40.0 ± 0.5% of cases. Consequently, home-produced dairy products can spread staphylococcal toxicity caused by S. aureus var. hominis. It was found that 17.8 ± 0.6% of S. aureus var. hominis were resistant to methicillin, which is 1.8 times greater than that of S. aureus var. bovis. This gives grounds to consider that there is a risk of MRSA infection to consumers of home-produced dairy products. All methicillin-resistant staphylococci studied produced enterotoxins.
Violência obstétrica em mulheres brasileiras
Authors: Palma Carolina Coelho , Donelli Tagma Marina Scheiner 
Published: September 2017

Esta pesquisa objetivou verificar a ocorrência de violência obstétrica em mulheres brasileiras. Realizou-se um estudo quantitativo, descritivo, transversal, de alcance correlacional e preditivo, utilizando-se o Questionário de Violência no Parto. Os dados foram coletados por acesso online ao questionário. Realizou-se análise descritiva, de correlação e de regressão, através do programa SPSS. Participaram da pesquisa 1626 mulheres adultas. Os resultados apontam que durante o parto 52,3% das gestantes sentiu-se inferior, vulnerável e insegura; 49,8% sentiu-se exposta e sem privacidade. A vivência de violência no parto apresentou correlação significativa com idade, escolaridade e renda familiar. Através da análise de regressão múltipla, verificou-se 12 práticas de atendimento ao parto que mostraram-se preditores significativos de violência no parto, explicando 34,9% da vivência de violência obstétrica. Percebe-se que intervenções desnecessárias são realizadas em nome de uma falsa impressão de que, quanto mais se intervém, mais se cuida.
Animal hoarding disorder: a systematic review
Authors: Paloski Luis Henrique , Ferreira Elisa Arrienti , Costa Dalton Breno , Huerto María Laura del , Oliveira Camila Rosa de , Argimon Irani Iracema De Lima , Irigaray Tatiana Quarti 
Published: September 2017

O objetivo principal deste artigo foi identificar estudos que investigaram o transtorno de acumulação de animais. Além disso, buscou verificar as características sociodemográficas dos indivíduos com esse transtorno, as condições do ambiente e dos animais, quantidade e espécies de animais acumulados, critérios diagnósticos e as intervenções terapêuticas utilizadas. Analisou-se artigos empíricos ou documentais, redigidos na língua inglesa, espanhola ou portuguesa, sem restritor de tempo. Dentre os 75 artigos encontrados, analisou-se nove artigos. Observou-se que os acumuladores, são do sexo feminino e acumulam em média, mais de 30 animais. As condições das habitações eram insalubres, e os animais mais acumulados são cães e gatos. O transtorno produz grande sofrimento para o indivíduo, para sua família e também para os animais. Conclui-se que devido à carência estudos empíricos sobre a temática, pesquisas necessitam ser realizadas para sanar essa lacuna e, consequentemente, construir estratégias de intervenções.
THE NEW LOOK AT NEUTROPHILIC GRANULOCYTES: RETHINKING OLD DOGMAS. PART 1
Authors: Nesterova I. V. , Kolesnikova N. V. , Chudilova G. A. , Lomtatidze L. V. , Kovaleva S. V. , Evglevsky A. A. , Nguyen T.D. L. 
Published: September 2017

Numerous modern basic research done undeniable fact that neutrophilic granulocytes (NG) are key effector and regulatory circuits both innate and adaptive immunity, and play a crucial role in the pathogenesis of a wide range of diseases. NG have potent receptor repertoire, providing a connection between them, cells of the immune system, as well as communication with endothelial cells, epithelial and other tissues. NG inducing stimuli activate and promote the translocation of cytoplasmic granules and vesicles surface molecules on the cytoplasmic membrane the secretion of a large spectrum of pro-and anti-inf lammatory, immunoregulatory cytokines, colony, angiogenic factors and fibrogenic, TNF superfamily members, chemokines, regulatory protein, etc. Chromatin nuclei NG capable of restructuring under the influence of inducing stimuli, which is associated with the expression of multiple cytokine genes. NG receiving complex cytokine inf luence not only acquire new features, but also in various stages of activation and differentiation processes involved in intracellular intraphagosomalis degranulation and killing of implementing elimination microorganisms and extracellular neutrophil degranulation in the formation neutrophil extracellular traps (NET), while this dying through NETosis. Features NG phenotype and their functional properties, demonstrate the existence of subpopulations of NG with different capabilities: equipment of different receptor, the ability to restructure chromatin expressing cytokine genes and secrete cytokines to implement the contents of the granular system, produce reactive oxygen species, implement cytotoxicity form NET. In our opinion, there subpopulation NG: regulatory; suppressor; proinf lammatory — initiating an inf lammatory response; inf lammation with a positive potential microbicidal (antibacterial, antiviral, antifungal); inf lammatory cytotoxic potential of the negative — “aggressive”; anti-inf lammation regulating regression; antitumoral — TAN1; pro-tumoral — TAN2; hybrid, combining the characteristics of NG and dendritic cells. The absence of adequate response, or hyperactivation blockade NG functions leads to the development of low-intensity infectious and inf lammatory diseases, do not respond to conventional therapy of autoimmune diseases/chronic immune-dependent processes. Remodeling dysfunctions NG — the key to new immunotherapeutic strategies.
COMMUNITY-ACQUIRED PNEUMONIA PNEUMOCOCCAL ETIOLOGY AND MICROBIOLOGICAL ASPECTS OF NASOPHARYNGEAL CARRIAGE IN CHILDREN IN THE REPUBLIC OF TATARSTAN
Authors: Bayazitova L. T. , Tyupkina O. F. , Chazova T. A. , Tyurin Y. A. , Isaeva G. S. , Zaripova A. Z. , Patyashina M. А. , Avdonina L. G. , Yuzlibaeva L. R. 
Published: September 2017

Prevalence estimate of pneumococcus carrier in preschool age children (medically fragile children with respiratory diseases and practically healthy organized children) have been carried out; microbiological features of clinical isolates S. pneumoniae have been studied. 511 S. pneumoniae strains isolated from medically fragile children with respiratory diseases aged between 6 months to 7 years during the period 2009–2016 and 47 isolates isolated from 200 practically healthy children attending preschool institutions of Kazan (2016) have been included in the research. Among 343 strains, 76 isolates were isolated during the period of 2009–2011; 82 strains — in 2012–2013; 87 strains — in 2014; 98 strains — in 2015; 168 strains — in 2016. Analysis of microbiocenosis of nasopharynx in medically fragile children showed that S. pneumoniae was sowed in 32.9% cases. In 58.4% of children it was as a monoculture (degree of colonization is 104–106 CFU/ml). S. pneumoniae contaminated nasopharynx in bacterial associations with other respiratory pathogens (S. aureus, Moraxella spp., Haemophilus spp.) in 41.6% of children. The analysis of microbiocenosis character of nasopharynx in children aged between 2.5–7 years attending preschool institutions in Kazan (n = 200) have showed that contamination S. pneumoniae (23.5%) was observed in 47 children. Pneumococcus have been isolated in monoculture in 82.9% of children; the contamination degree made 103–106 CFU/ml. According to serotyping data, nasopharynx of often and long-term ill children living in Kazan is colonized by serotypes of pneumococcus which are covered with 13 valence conjugated serum. The obtained data on the dynamics of strain S. pneumoniae antibiotic sensitivity among medically fragile children with respiratory diseases in Kazan during 2009–2015 showed high activity of β-lactams antibiotics (from 96 to 90.8% sensitive isolates) and clyndamicin (94.7–91.8% sensitive straines). Macrolides (azytromicin, clarytromicin) and phtorchinolons (ciprof loxacin) are less active in regard to isolates S. рneumoniae. S. pneumoniae with multiple antibiotic resistance were detected in children nasopharynx: 3.8–9.95 in medically fragile children and 8.5% in organized children-bactericides. Identification of the carrier level S. pneumoniae and monitoring the dynamics on antibiotic resistance and serotyping composition of nasopharyngeal pneumococcus will optimize prevention and treatment of infections S. pneumoniae in preschool children.
EFFICACY OF GENERIC DRUG WARTOCID® (IMIQUIMOD 5% CREAM FOR EXTERNAL USE) IN ANOGENITAL WARTS TREATMENT
Authors: Smirnova V. S. , Petlenkoa S. V. , Savelyeva S. A. , Redlichb G. , Stukana N. I. 
Published: September 2017

Aim. To evaluate the efficacy and safety of the generic drug Wartocid® (Imiquimod cream 5% for external use) in patients with external anogenital (venereal) warts (AGW). Materials and methods. The single-blind comparative, randomized, placebo-controlled clinical trial included 50 women aged 18 to 60 with an established clinical diagnosis of AGW in the vulva and perianal region. Patients in group 1 received placebo cream for external use, while patients in group 2 received therapy with Wartoсid in a daily dose of 10 mg cream/cm2 of skin area. The drug was applied every other day until the complete disappearance of AGW, but in any case, not more than 16 weeks. A follow-up was carried out for 4 more weeks. The study evaluated the dynamics of subjective and objective symptoms, the presence and the frequency of relapses, and the percentage of full treatment of AGW.Main results. Treatment with Wartoсid resulted in a complete cure of AGW in 16% of patients, and a reduction in the focus area of AGW in 36% of patients. Against the background of the placebo no dynamics of the disease were reached. Neither serious adverse events nor clinically significant changes in blood tests, urine or serum biochemical parameters in any of the patients who received treatment with Wartoсid were observed. Conclusion. The generic drug Wartocid has been proved to be effective and safe for AGW treatment and its effectiveness is similar to the original drug Aldara® (Imiquimod cream 5% for external use).
Modeling of Teaching 5th-7th-Grade Boys Physical Exercises
Authors: Abdulkhalikova T. H. 
Published: September 2017

The research objective is to determine the effectiveness of orthogonal variants of teaching 5th-7th graders physical exercises.Materials and methods. The participants in the research were boys of the 5th grade (n = 32), 6th grade (n = 40), 7th grade (n = 52). To achieve the tasks set, the research used the following methods: analysis of scientific and methodological literature; pedagogical testing, pedagogical observation, timing of educational tasks; pedagogical experiment, medical and biological research methods; methods of mathematical statistics, methods of mathematical experiment planning.In order to achieve the objective set, the research has studied the effect of different variants of the educational process structure, namely: the number of repetitions (х1) and rest intervals (х2) when learning the technique of performing physical exercises. The research has conducted a complete factor experiment of type 22. According to the experiment plan, the 5th-7th graders were divided into training groups. In total, there were 12 experimental groups organized.Research results. The analysis of the regression equations shows that the teaching of physical exercises to the 5th-7th-grade boys is mostly influenced by rest intervals between repetitions (х2). The number of repetitions (х1) has somewhat less influence. The interaction of these factors is insignificant when teaching physical exercises and becomes much more influential only when teaching a switch leg pull-over exercise (х1х2).Conclusions. To increase the effectiveness of teaching 5th-7th graders physical exercises, it is necessary to shorten rest intervals between repetition to 60 s and to reduce the number of repetitions to six. When teaching boys the switch leg pull-over exercise, rest intervals should be increased to 120 s and the number of repetitions — to twelve.
Indenizações que envolvem o parto à luz do entendimento do Superior Tribunal de Justiça - STJ
Authors: Rodrigues Thaísa Mara Leal Cintra , Nunes Altacilio Aparecido 
Published: September 2017

Introdução: O Ministério da Saúde tem apostado na mudança da cultura do parto, a fim de estabelecer diretrizes baseadas na assistência humanizada. Os médicos obstetras têm papel relevante nesse processo, pois participam de maneira ativa na aplicação do conhecimento e das melhores técnicas para realização de um parto seguro. Métodos: O trabalho analisou o discurso dos julgadores do Superior Tribunal de Justiça (STJ), nas ações indenizatórias envolvendo partos, mediante o estudo do Discurso do Sujeito Coletivo (DSC), o qual reflete opiniões e posicionamentos relacionados à área médica obstétrica. Resultados: O discurso dos julgadores do STJ ressaltou a responsabilidade objetiva dos hospitais, sejam públicos ou privados, ao passo que aos médicos foi atribuída a responsabilidade subjetiva, devendo ser comprovada a culpa do profissional. As provas periciais produzidas foram essenciais para o desfecho da ação. As ações improcedentes sustentaram que a obrigação de meio excluiu a responsabilidade, desde que realizados todos os procedimentos necessários e adequados. A União foi considerada parte ilegítima para responder pelos danos relacionados ao Sistema Único de Saúde. Discussão: Os discursos sugerem discussões acerca da mudança gradativa entre os envolvidos no processo gestacional e puerperal, inclusive aos operadores do direito, aplicadores da lei ao caso concreto, assim como aos profissionais da saúde obstétrica no exercício da profissão. Conclusão: Os casos analisados debateram sobre os riscos da prática médica obstétrica, o que pode ser objeto de reflexão, a fim de reduzir custos provenientes das altas indenizações, bem como incentivar a humanização, a qualidade e excelência na assistência ao parto.
A Methodology for Predictive Maintenance in Semiconductor Manufacturing
Authors: Scheibelhofer Peter , Gleispach Dietmar , Hayderer Günter , Stadlober Ernst 
Published: September 2017

In order to occupy a competitive position in semiconductor industry the most important challenges a fabrication plant has to face are the reduction of manufacturing costs and the increase of production yield. Predictive maintenance is one possible way to address these challenges. In this paper we present an implementation of a universally applicable methodology based on the theory of regression trees and Random Forests to predict tool maintenance operations. We exemplarily show the application of the method by constructing a model for predictive maintenance of an ion implantation tool. To fit theproblem adequately and to allow a descriptive interpretation we introduce the remaining time until next maintenance as a response variable. By using R and adequately analyzing data acquired during wafer processing a Random Forest model is constructed. We can show that under typical production conditionsthe model is able to predict a recurring maintenance operation sufficiently accurate. This example shows that better planning of maintenance operations allows for an increase in productivity and a reduction of downtime costs.
Estimation of P(Y < X) in a Four-Parameter Generalized Gamma Distribution
Authors: Masoom Ali M. , Pal Manisha , Woo Jungsoo 
Published: September 2017

In this paper we consider estimation of R = P(Y < X), when X and Y are distributed as two independent four-parameter generalized gamma random variables with same location and scale parameters. A modified maximum likelihood method and a Bayesian technique have been used to estimate R on the basis of independent samples. As the Bayes estimator cannot be obtained in a closed form, it has been implemented using importance sampling procedure. A simulation study has also been carried out to compare the two methods.
Bayesian Analysis of Randomly Censored Generalized Exponential Distribution
Authors: Danish Muhammad Yameen , Aslam Muhammad 
Published: September 2017

This paper deals with Bayesian analysis of two-parameter generalized exponential distribution in proportional hazards model of random censorship. It is well known for two-parameter lifetime distributions that continuous conjugate priors for the parameters do not exist; we assume independent gamma priors for the scale and shape parameter. It is seen that the closed-form expressions for the Bayes estimators cannot be obtained; we suggest Tierney-Kadane’s approximation to obtain the Bayes estimates. However with this method, it is not possible to construct the HPD credible intervals, we propose Gibbs sampling procedure to approximate the Bayes estimates and also to construct the HPD credible intervals. Monte Carlo simulationis carried out to observe the behavior of the proposed methods and to compare with maximum likelihood method. One real data analysis is performed for illustration.
Statistical Indicators for the Analysis of Digitalized Brain Tumor Images
Authors: Templ Matthias , Aklan Semaguel , Filzmoser Peter , Preusser Matthias , Hainfellner Johannes A. 
Published: September 2017

In this contribution, indicators for computer-based analysis and assessment of tumor cell proliferation in human brain tumors are developed. The methods are applied on (two) samples of digitized human brain tumor tissue sections immunostained with an antibody against the Ki67 epitope. The Ki67 immunostaining highlights cells undergoing cell division and is thus a surrogate marker for tumor growth.The challenges are related to the enormous size of the images (“big data”) analyzed, some of them are larger than 100 GB. Thus, efficient methods to extract relevant information have to be applied.Before starting with the statistical analysis, the digitized images are preprocessed to extractthe highlighted cells. Then the distribution of Ki67 immunostaining patterns is analyzed. Starting with a bivariate kernel density estimation, the proposed indicators are used to evaluate and compare the resulting density estimates. Moreover, the spatial distribution of clusters of Ki67-labeled tumor cells is of particular interest.The results allow to evaluate and compare images or sectors of the images. This evaluation and comparisons of samples or sectors could turn out to be useful in practice since it allows for a pre-selection of interesting sectors and samples. Thus, the time-consuming part of manual inspection of the hugeimages could be reduced.
Eine empirische Studie zur Verifikation von Unterschriften und zur Indikation von Fälschungen
Authors: Wälder Olga , Kutzner Tobias 
Published: September 2017

Eine zufällige Stichprobe von Unterschriften, die auf mobilen Geräten mit Touch-Screen Display erzeugt wurde, soll hinsichtlich ihrer Verifikation untersucht werden. Zu diesem Zweck wurden verschiedeneKlassifizierungsalgorithmen verwendet und miteinander verglichen. Ein weiterer Datensatz wurde erfolgreich auf Indikation der Fälschungen untersucht. Zudem wird in diesem Beitrag eine Transformation der ursprünglichen Variablen beschrieben, die zur Erhöhung der Qualität sowohl der Verifikation,als auch der Indikation der Fälschung beigetragen hat.
Book Reviews: Rehman M. KHAN (2013). Problem Solving and Data Analysis using Minitab — A Clear and Easy Guide to Six Sigma Methodology.
Authors: Viertl R. 
Published: September 2017

Rehman M. KHAN (2013). Problem Solving and Data Analysis using Minitab — A Clear and Easy Guide to Six Sigma Methodology. (Wiley Series in Probability and Statistics), John Wiley & Sons Ltd, Chichester, UK, 484 Seiten, gebunden, ISBN 978-1-118-30757-1 (cloth) (e57.60)
ESPIRITUALIDADE EM EMPRESAS DE SEGURANÇA PRIVADA
Authors: Paula Jean Carlos Rodrigues de , Tassigny Mônica Mota , Brasil Marcus Vinícius de Oliveira , Bizarria Fabiana Pinto de Almeida , Frota Antônio Jackson Alcantara 
Published: September 2017

O artigo analisa a percepção de espiritualidade de gestores de empresas de segurança privada com suporte nos princípios de vida interior, comunidade e voltada para a compreensão do significado do trabalho. Realizou-se um survey com 52 gestores executivos de empresas de segurança privada da Cidade de Fortaleza-Ceará, tendo como instrumento de pesquisa a escala de Ashmos e Duchon (2000). Por meio de análise fatorial exploratória inferiu-se como resultados valores organizacionais associados à espiritualidade e voltados para a comunidade. O uso de princípios como “vida interior” ou relacionados com o entendimento sobre o “significado do trabalho” foram também evidenciados. Concluiu-se que os gestores reconhecem sua vida interior como parte de sua realização profissional. Embora, ainda associem espiritualidade a religião. Por fim, pode-se inferir que a compreensão de que há espiritualidade favorece o sentimento de totalidade e conectividade do papel construtivo da empresa.