bluuebunny/crossref_metadata_2025_split huggingface dataset:
The journey to building a diverse, equitable, and inclusive American Medical Informatics Association
Authors: Bright Tiffani J , Bear Don’t Walk IV Oliver J , Johnson Carl Erwin , Petersen Carolyn , Dykes Patricia C , Martin Krista G , Johnson Kevin B , Walters-Threat Lois , Craven Catherine K , Lucero Robert J , Jackson Gretchen P , Rizvi Rubina F 
Published: October 2024

Abstract

Objective
The American Medical Informatics Association (AMIA) Task Force on Diversity, Equity, and Inclusion (DEI) was established to address systemic racism and health disparities in biomedical and health informatics, aligning with AMIA’s mission to transform healthcare. AMIA’s DEI initiatives were spurred by member voices responding to police brutality and COVID-19’s impact on Black/African American communities.

Materials and Methods
The Task Force, consisting of 20 members across 3 groups aligned with AMIA’s 2020-2025 Strategic Plan, met biweekly to develop DEI recommendations with the help of 16 additional volunteers. These recommendations were reviewed, prioritized, and presented to the AMIA Board of Directors for approval.

Results
In 9 months, the Task Force (1) created a logic model to support workforce diversity and raise AMIA’s DEI awareness, (2) conducted an environmental scan of other associations’ DEI activities, (3) developed a DEI framework for AMIA meetings, (4) gathered member feedback, (5) cultivated DEI educational resources, (6) created a Board nominations and diversity session, (7) reviewed the Board’s Strategic Planning for DEI alignment, (8) led a program to increase diversity at the 2020 AMIA Virtual Annual Symposium, and (9) standardized socially-assigned race and ethnicity data collection.

Discussion
The Task Force proposed actionable recommendations that focused on AMIA’s role in addressing systemic racism and health equity, helping the organization understand its member diversity.

Conclusion
This work supported marginalized groups, broadened the research agenda, and positioned AMIA as a DEI leader while reinforcing the need for ongoing transformation within informatics.
HDAC7 promotes cardiomyocyte proliferation by suppressing Myocyte Enhancer Factor 2
Authors: Jang Jihyun , Bentsen Mette , Bu Jin , Chen Ling , Campos Alexandre Rosa , Looso Mario , Li Deqiang 
Published: October 2024

Abstract
Postnatal mammalian cardiomyocytes (CMs) rapidly lose proliferative capacity and exit the cell cycle and undergo further differentiation and maturation. Cell cycle activation has been a major strategy to stimulate postnatal CM proliferation, albeit achieving modest effects. One impediment is that postnatal CMs may need to undergo dedifferentiation before proliferation, if not simultaneously. Here, we report that overexpression of Hdac7 in neonatal mouse CMs results in significant CM dedifferentiation and proliferation. Mechanistically, we show that HDAC7-mediated CM proliferation is contingent on dedifferentiation, which is accomplished through suppressing MEF2. Hdac7 overexpression in CM shifts the chromatin state from binding MEF2, which favors the differentiation transcriptional program to AP-1, which favors the proliferative transcriptional program. Further, we found that HDAC7 interacts with minichromosome maintenance complex (MCM) components to initiate cell cycle progression. Our findings reveal that HDAC7 promotes CM proliferation by its dual action on CM dedifferentiation and proliferation, uncovering a potential new strategy for heart regeneration/repair.
The association of resilience with HbA1c and key psychosocial factors in emerging adults with type 1 diabetes
Authors: O’Daffer Alison , Yi-Frazier Joyce P , Roberts Alissa J , Lowry Sarah J , Pihoker Catherine , Hirsch Irl B , Weaver Kathryn W , Zenno Anna , Malik Faisal S 
Published: October 2024

Abstract

Objective
Emerging adults (EAs) with type 1 diabetes (T1D) have difficulty meeting glycemic targets and have a high prevalence of mental health comorbidities. Resilience, the ability to harness resources needed to sustain one’s emotional and physical well-being, may be a key factor impacting poor mental health and glycemic outcomes. We aimed to (a) evaluate the association between resilience, HbA1c, and key psychosocial factors and (b) explore whether resilience moderates the relationship between psychosocial factors (depression, diabetes-related distress, anxiety) and HbA1c in EAs with T1D.

Method
EAs with T1D (N = 233) (mean age = 19.9 years (SD = 1.6), range 16.8–24.7) seen at an EA-specific diabetes clinic completed resilience, diabetes-related distress, depression, and anxiety measures and had their HbA1c level evaluated. We used linear regression models and conducted moderation analyses for the resilience factor.

Results
Resilience was strongly associated with HbA1c, depression, diabetes-related distress, and anxiety in EAs with T1D. We did not find evidence that resilience moderates the relationship between depression, anxiety, or diabetes-related distress and HbA1c.

Conclusions
This study found that resilience is a highly relevant psychological factor associated with HbA1c and a key mental health factor for EAs with T1D. Novel interventions are needed to ameliorate high diabetes-related distress and HbA1c, and bolstering resilience may be one avenue to explore. Future research on resilience should longitudinally characterize and evaluate whether resilience may be a mechanism underlying the relationship between poor psychosocial outcomes and not meeting glycemic targets in EAs with T1D.
Phenotypic and molecular characterization of vancomycin resistant enterococci from wild birds: first detection of a plasmid-borne vanC1 in Enterococcus faecalis
Authors: Hachem Yousra , Djouadi Lydia Neila , Raddaoui Anis , Boukli-Hacene Fella , Boumerdassi Hanane , Achour Wafa , Nateche Farida 
Published: October 2024

Abstract
Vancomycin-resistant enterococci (VRE) are a public health concern as they lead to therapeutic impasses and play a pivotal role in the dissemination of vancomycin resistance genes. As recent evidence suggests that wildlife can play a role in the dissemination of bacterial resistomes, this study explored the potential role of Algerian wild birds as a reservoir of VRE. A total of 222 cloacal and fecal samples were collected from various wild bird species and screened for VRE using a selective medium. Of the 47 isolated strains, 22 were identified as Enterococcus casseliflavus with the vanC2/C3 gene, 24 as Enterococcus gallinarum (19 carrying vanC1 and five carrying vanC2/C3), and one strain as Enterococcus faecalis with the vanC1 gene. Twenty-four (24) strains were multidrug-resistant with 61.7% resistant to rifampicin, while no resistance to teicoplanin, linezolid, and gentamicin was found. Additionally, 53.20% of the strains exhibited at least one virulence factor. To our knowledge, this study represents the first documentation of the vanC1 gene in E. faecalis isolated from wild birds. Furthermore, this gene was found to be carried by a conjugative plasmid, highlighting its ability to spread among bacterial populations and lead to the emergence of novel resistance phenotypes.
Deep H i mapping of M 106 group with FAST
Authors: Liu Yao , Zhu Ming , Yu Hai-Yang , Zhou Rui-Lei , Xu Jin-Long , Ai Mei , Jiang Peng , Yuan Li-Xia , Zhang Hai-Yan 
Published: October 2024

ABSTRACT
We used Five-hundred-meter Aperture Spherical radio Telescope (FAST) to conduct deep H i imaging of the entire M 106 group region, and have discovered a few new H i filaments and clouds. Three H i clouds/filaments are found in a region connecting DDO 120 and NGC 4288, indicating an interaction between these two galaxies. The H i features in this region suggest that DDO 120 is probably the origin of the H i stream extending from the northern end of NGC 4288 to M 106. This structure is similar to the Small–Large Magellanic Cloud stream, but much longer, about 190 kpc. Furthermore, based on the distance measurements, we have determined the satellite galaxy members of M 106. With an absolute magnitude cutoff of $M_{B}$ = −10, we obtained a sample of 11 member satellite galaxies for M 106. Using the observed H i mass with FAST, we studied the properties of satellite galaxies in M 106 and found that satellite galaxies with lower stellar masses exhibit more significant deviations from the star-forming main sequence in their specific star formation rates. Furthermore, the relationship between the H i mass of satellite galaxies and optical diameter generally follows the field galaxies relation. We discuss the possible mechanisms leading to the quenching in the M 106 group based on the new data from FAST.
Wanting to Be “Accepted and Heard”: Perspectives About Cessation Messages From LGBTQ+ Individuals Who Dual Use Cigarettes and E-Cigarettes
Authors: Hill Frantasia T , Clark Sonia A , Ross Dew Kelsey , Lee Joseph G L , Goldstein Adam O , Byron M Justin 
Published: October 2024

Abstract

Introduction
Dual use of cigarettes and e-cigarettes is especially prevalent among lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ+) adults in the United States. This is concerning as the health risks of dual use may be as high or higher than exclusive smoking..

Aims and Methods
We sought to learn the perspectives of LGBTQ+ adults who dual use about dual use, quitting, and cessation ads. Nineteen LGBTQ+ adults who dual use participated in virtual semi-structured interviews in North Carolina in 2022. We asked about perceptions of smoking and vaping in LGBTQ+ communities, their thoughts about quitting, and their opinions on four cessation ads. The ads advocated quitting one or both products. Transcripts were coded using ATLAS.ti and reviewed using a thematic content analysis approach.

Results
Participants described how within LGBTQ+ communities, smoking and vaping are common and accepted and are used to cope or to socialize. Most participants made past quit attempts. Many said they were not ready to quit both products, but some were open to quitting smoking. Some thought e-cigarettes may be as harmful as cigarettes, reducing their motivation to quit smoking cigarettes due to the lack of perceived health benefit. Participants sought cessation ads that explicitly address dual use and are representative and supportive. They disliked ads that felt stereotypical or patronizing.

Conclusions
Dual use in LGBTQ+ communities appears driven by both internal and external pressures. Participants were generally open to quitting cigarettes, and LGBTQ+ smoking cessation may be best encouraged with authentic ads that explicitly address both products.

Implications
These qualitative findings about smoking and vaping among LGBTQ+ individuals provide guidance for communication ad campaign design to help reduce the high dual-use rates among LGBTQ+ adults.
Imprinting New Physics by Using Angular Profiles of the Flavor-Changing-Neutral-Current Process Bc → Ds* (→ Dsπ) ℓ+ℓ-
Authors: Waseem Hira , Hafeez Abdul 
Published: October 2024

Abstract
The decays governed by the flavor-changing-neutral-current (FCNC) transitions, such as $b\rightarrow s\ell ^{+}\ell ^{-}$, provide an important tool to test the physics in and beyond the Standard Model (SM). This work focuses on investigating the FCNC process $B_{c}\rightarrow D_{s}^{*} \left(\rightarrow D_{s}\pi \right)\ell ^{+}\ell ^{-}(\ell =e,\mu ,\tau )$. Being an exclusive process, the initial and final state meson matrix elements involve the form factors, which are nonperturbative quantities and need to be calculated using specific models. By using the form factors calculated in the covariant light-front quark model, we analyze the branching fractions and angular observables such as the forward-backward asymmetry $A_{\mathrm{ FB}}$, polarization fractions (longitudinal and transverse) $F_{L(T)}$, CP asymmetry coefficients $A_{i}$, and CP-averaged angular coefficients $S_{i}$, both in the SM and in some new physics (NP) scenarios. Some of these physical observables are a potential source of finding the physics beyond the SM and help us to distinguish various NP scenarios.
Italian winegrowers' acceptance of result-based agri-environmental schemes
Authors: Muzzillo Margherita , Arata Linda , Rommel Jens , Sckokai Paolo 
Published: October 2024

Abstract
As the debate around the cost-effectiveness of agri-environmental schemes (AES) is growing at the European level, researchers and policymakers are exploring the potential of result-based AES. Result-based AES initiate payments only if pre-defined environmental outcomes are achieved, thus increasing risks for farmers. Using a contingent valuation method, we investigated Italian winegrowers’ acceptance and intensity of participation in a result-based AES targeted at pollinators’ conservation in vineyards. We focused on the role of farmers’ behavioural factors and risk attitudes in driving the acceptance. Results show that, among the 222 farmers who completed the survey, 71 per cent of participants are willing to participate in such a scheme. Non-participation is associated with a high perceived bureaucratic burden. Risk also plays a significant role, as the perceived risk of the scheme decreases the likelihood of enrolment, while risk-seeking farmers are more likely to participate. We found no evidence of risk affecting the intensity of participation. In contrast, while a treatment of a randomly assigned rare-species bonus did not affect the scheme's overall acceptance, it positively influenced intensity. Behavioural factors appear to be related to both acceptance and intensity. Considering this, we suggest strategies to encourage farmer participation in result-based AES.
Correlation Between Quantitative Cage Pressure Measurements and Surgeons’ Qualitative Tactile Assessments During Extraction in Lumbar Lateral Interbody Fusion
Authors: Sono Takashi , Shimizu Takayoshi , Murata Koichi , Yamamoto Koji , Matsuda Shuichi , Otsuki Bungo 
Published: October 2024

Study Design:
A cadaveric study.

Objective:
Measuring the pressure exerted on lumbar lateral interbody fusion (LLIF) cages and examining its correlation with qualitative assessment of tactile feedback related to pullout strength during cage extraction to determine the optimal cage height.

Summary of Background Data:
No data exists on the relationship between the surgeon’s tactile feedback related to pullout strength during the LLIF cage extraction and the cage pressures measured during surgery.

Methods:
We used four cadavers to insert the original stress-measuring cages at the L2/3 to L4/5 levels (12 intervertebral spaces) using the oblique lumbar lateral approach. The intervertebral disc height (IDH) was measured before cage insertion. These stainless-steel stress-measuring cages were designed with the same shape as standard cages and included a built-in load cell to measure the stress applied. The cage heights were set at 8, 10, and 12 mm and they were inserted sequentially from 8mm, with stress measurements taken at each step. Four spine surgeons qualitatively evaluated the extraction strength using three rating categories (“loose,” “appropriate,” and “hard to extract”). After cage removal, endplate damage (ED) and anterior longitudinal ligament injury (ALLI) were checked. The anterior part of the vertebral body was dissected to expose the ALL and it is checked for obvious injuries. Additionally, a surgical probe is used to check for ED and ALLI.

Results:
The measured cage pressures were 45, 120, and 191 N for the “loose,” “appropriate,” and “hard to extract” ratings, respectively (P < 0.001). ED was observed in five intervertebral spaces, whereas no ALLI was noted. The average maximum pressure when ED occurred was 127 N. The primary risk factor for ED was identified as the difference between the height of the inserted cage and IDH, with a cut-off value of 4.5 mm.

Conclusion:
The appropriate extraction strength corresponded to a cage pressure of 120 N. A cage pressure ≥127 N posed a risk for ED. ED incidence was high when the difference between the IDH and the height of the inserted cage exceeded 4.5 mm.

Level of Evidence:
Level Three
Comparable Overall Risk of Neurologic Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections
Authors: Seddio Anthony E. , McNamara Katelyn F. , Gouzoulis Michael J. , Jabbouri Sahir S. , Vasudevan Rajiv S. , Day Wesley , Ratnasamy Philip P. , Rubio Daniel R. , Grauer Jonathan N. 
Published: October 2024

Study Design/Setting.
Retrospective cohort study

Objective.
To characterize the incidence and odds of neurologic adverse events following interlaminar (IL) and transforaminal (TF) cervicothoracic epidural spinal injections (CESI).

Summary of Background Data.
CESI may be considered in the management of various cervical pathology. Adverse events, although rare, can be devastating and have been reported following both IL and TF injections. The literature is mixed with regard to the risk-profile of these two types of CESI, but is largely limited to case reports, single centered studies, and literature reviews, which may incompletely characterize the relative risk of these injections at a national level.

Methods.
All adult patients undergoing IL and TF-CESI were identified from a large, national, multi-insurance database. The incidence of any post-injection neurologic complication was reported per 1,000 patients. The odds of specific neurologic adverse events occurring within 48-hours following TF-CESI, relative to IL-CESI, were compared by multivariable logistic regression controlling for age, sex, and Elixhauser comorbidity index (ECI).

Results.
A total of 1,073,215 IL-CESI patients and 220,597 TF-CESI patients were identified. The overall incidence of any neurologic complication following IL and TF-CESI occurred at a rate of 4.15 and 4.56 per 1,000 patients, respectively (P=0.889). TF-CESI was associated with higher odds ratio (OR) of nerve root injury (OR 1.69, P<0.001), but lower odds of epidural hematoma (OR 0.60, P=0.040), relative to IL-CESI. Conversely, no other neurologic adverse events were statistically different between approaches (P>0.05 for all).

Conclusions.
Following IL and TF-CESI, adverse events are relatively rare but not absent. Although the odds of the majority of individual neurologic adverse events were found to be similar, both approaches were independently associated with specific complications. Providers should therefore recognize that, at the national level, one CESI approach may not be universally associated with a lower risk of complications.
Effect of Nurse-Assisted Early Warning Intervention for Prevention of Venous Thromboembolism Following Cesarean Delivery
Authors: Wan Bichao , Fu Dongying , Chen Shijiang , Tao Fuying , Jiang Jianan , Tian Yingying 
Published: October 2024

Abstract

Objective
The aim of the study is to assess the role of a nurse-assisted early warning intervention in improving prophylaxis against obstetric venous thromboembolism (VTE) and preventing VTE following cesarean delivery (CD).

Methods
A prospective cohort study conducted between January 1, 2020, and December 30, 2022, enrolled pregnant women who underwent CD in the obstetric unit of Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital. The patients were assigned to a control group (routine nursing care) or the intervention group (nurse-assisted early warning intervention) depending on whether or not the nurse-assisted early warning intervention had been implemented. The χ
2 test and Student’s t test were used for statistical analysis. The primary outcome was the incidence of systemic VTE following CD, and secondary outcomes were the rates of mechanical or pharmacologic prophylaxis receipts for VTE and the frequency and severity of adverse events related to pharmacologic prophylaxis.

Results
A total of 27,074 cases were enrolled. The incidence of symptomatic VTE following CD was significantly lower in the intervention group (0.29 per 1000 deliveries) than in the control group (2.4 per 1000 deliveries) (P < 0.001). Significantly more cases received mechanical and pharmacological VTE prophylaxis in the intervention group than in the control group (respectively, 19.8% vs. 12.6% receiving mechanical prophylaxis and 0.9% vs. 0.2% receiving pharmacological prophylaxis). No cases of life-threatening bleeding occurred in either group.

Conclusion
The application of nurse-assisted early warning intervention may be an effective method for preventing VTE following CD.
High-dose chemotherapy with autologous stem cell rescue in children and young adults with high-risk Ewing sarcoma
Authors: Lee Chih-Ying , Hou Ming-Hsin , Hung Giun-Yi , Ho Cheng-Yin , Yu Ting-Yen , Wu Po-Kuei , Chen Chao-Ming , Yen Chueh-Chuan , Shiau Cheng-Ying , Chen Paul Chih-Hsueh , Wu Hung-Ta Hondar , Wu Ching-Lan , Yen Hsiu-Ju , Chen Wei-Ming 
Published: October 2024

Background:
A combination treatment of surgery, chemotherapy, and radiotherapy can improve the survivals of pediatric patients with Ewing sarcoma (ES). However, prognosis remains poor for patients with metastatic disease at diagnosis or recurrence. Other high-risk (HR) features include large tumor burden, tumors of the axial skeleton, and poor histologic response. Several studies have documented high-dose chemotherapy with autologous stem cell rescue (HDC-ASCR) to be effective in such patients. In this retrospective study, we present the results of HDC-ASCR for high-risk ES (HRES) in children and young adults in a single institute.

Methods:
From March 2004 to March 2021, patients with ES, Ewing-like sarcoma, or round cell sarcoma received HDC-ASCR as part of treatment were included. The patients’ characteristics, disease status, stem cell dose, engraftment status, post-transplant complications, and outcomes were analyzed.

Results:
Twenty patients receiving HDC-ASCR at complete response (n = 6), partial response (n = 13), and stable disease (n = 1) were enrolled. The male-to-female ratio was 11:9. Median age at diagnosis and transplant was 15.6 years old (range: 3.3-28.9) and 16.2 (range: 4.2-29.9), respectively. The conditioning regimens included ifosfamide-based in two and melphalan-based in 19. All patients achieved successful engraftment without transplant-related mortality. The 5-year progression-free and overall survival (OS) rate were 35% and 54.5%, respectively. The causes of death (n = 8) were all contributed to disease progression. Patients in the complete response group or with localized HRES exhibited a higher 5-year OS (p = 0.047 and 0.05, respectively). Compared with the historical cohort without HDC-ASCR as part of primary treatment, the current cohort had a significantly better 5-year OS (p = 0.018).

Conclusion:
HDC-ASCR seems promising as an alternative treatment for HRES in improving OS in this retrospective study with a limited case number.