bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal Trends and Temperature-Related Incidence of Electrical Storm
Authors: Guerra Federico , Bonelli Paolo , Flori Marco , Cipolletta Laura , Carbucicchio Corrado , Izquierdo Maite , Kozluk Edward , Shivkumar Kalyanam , Vaseghi Marmar , Patani Francesca , Cupido Claudio , Pala Salvatore , Ruiz-Granell Ricardo , Ferrero Angel , Tondo Claudio , Capucci Alessandro 
Published: March 2017

Background—
The occurrence of ventricular tachyarrhythmias seems to follow circadian, daily, and seasonal distributions. Our aim is to identify potential temporal patterns of electrical storm (ES), in which a cluster of ventricular tachycardias or ventricular fibrillation, negatively affects short- and long-term survival.

Methods and Results—

The TEMPEST study (Circannual Pattern and Temperature-Related Incidence of Electrical Storm) is a patient-level, pooled analysis of previously published data sets. Study selection criteria included diagnosis of ES, absence of acute coronary syndrome as the arrhythmic trigger, and ≥10 patients included. At the end of the selection and collection processes, 5 centers had the data set from their article pooled into the present registry. Temperature data and sunrise and sunset hours were retrieved from Weather Underground, the largest weather database available online. Total sample included 246 patients presenting with ES (221 men; age: 65±9 years). Each ES episode included a median of 7 ventricular tachycardia/ventricular fibrillation episodes. Fifty-nine percent of patients experienced ES during daytime hours (
P
<0.001). The prevalence of ES was significantly higher during workdays, with Saturdays and Sundays registering the lowest rates of ES (10.4% and 7.2%, respectively, versus 16.5% daily mean from Monday to Friday;
P
<0.001). ES occurrence was significantly associated with increased monthly temperature range when compared with the month before (
P
=0.003).

Conclusions—
ES incidence is not homogenous over time but seems to have a clustered pattern, with a higher incidence during daytime hours and working days. ES is associated with an increase in monthly temperature variation.

Clinical Trial Registration—

https://www.crd.york.ac.uk
. Unique identifier: CRD42013003744.
Graft Site Morbidity in Elbow Ligament Reconstruction Procedures: A Systematic Review
Authors: Hagemeijer Noortje C. , Claessen Femke M.A.P. , de Haan Roel , Riedijk Roeland , Eygendaal Denise E. , van den Bekerom Michel P. 
Published: March 2017

Background:It is unclear which tendon harvest for ulnar or lateral collateral ligament reconstruction has the lowest graft site morbidity rate.Purposes:To obtain graft site morbidity rates after tendon harvest for ulnar and lateral collateral ligament reconstruction procedures.Study Design:Systematic review/Meta-analysis.Methods:Studies were eligible if (1) patients had undergone elbow ligament reconstruction procedures; (2) original data for at least 5 patients were available; (3) the article was written in English, German, or Dutch; (4) a full-text article was available; and (5) information about graft site morbidity was available. The review excluded studies about complicated elbow ligament reconstruction procedures due to initial fractures, revision procedures, or circumferential graft techniques; animal studies; (systematic) reviews; and expert opinions. Because the majority of studies were case reports, no selection form or overall scoring system to evaluate methodological quality was used.Results:The review included 619 patients with an ulnar or lateral collateral ligament reconstruction procedure. The autograft types used included palmaris longus tendon (58%), gracilis tendon (24%), semitendinosus tendon (8%), triceps tendon (7%), toe extensor tendon (<2%), plantaris tendon (<2%), extensor carpi radialis longus tendon (<1%), and Achilles tendon (<1%).Conclusion:Graft site morbidity occurred in 1% of the patients after an ulnar or lateral collateral ligament reconstruction procedure. This study did not have enough samples of all the autograft types to conclude that autograft type and graft site morbidity are unrelated.
Balance Markers in Adolescents at 1 Month Postconcussion
Authors: Rochefort Coralie , Walters-Stewart Coren , Aglipay Mary , Barrowman Nick , Zemek Roger , Sveistrup Heidi 
Published: March 2017

Background: The Balance Error Scoring System (BESS) shows that balance tends to recover within days after a concussion, whereas measures of the movement of the center of pressure (COP) show that balance deficits can persist up to 1 month after concussion. While approximately 30% of adolescents suffering concussion have functional consequences including balance deficits, evidence of the use of different balance assessments for concussion is limited within this population. Purpose: To compare performance on a series of balance assessments between adolescents with a diagnosed concussion at 1 month postinjury and noninjured control participants within the same age distribution. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Thirty-three adolescents 1 month postconcussion and 33 control participants completed the BESS followed by two, 2-minute trials standing on a Nintendo Wii Balance Board (WBB), during which the COP under their feet was recorded using 2 testing protocols: (1) double-leg stance, eyes open (EO) and (2) double-leg stance, eyes closed (EC). Participants then completed a dual-task condition (DT) with eyes open combining a double-leg stance and a Stroop color and word test while standing on the WBB. Three commonly used COP variables, anterior-posterior (A/P) and mediolateral (M/L) velocity and 95% ellipse, were computed for each condition performed on the WBB. Results: Participants postconcussion swayed over a significantly larger ellipse area compared with the control group in the EO ( P = .008), EC ( P = .002), and DT ( P = .003) conditions and also performed the DT condition with faster COP velocity in the M/L direction ( P = .007). No significant group difference was identified for BESS total score. Conclusion: At 1 month postconcussion, participants continued to demonstrate balance deficits in COP control despite scoring similar to controls on the BESS. Simple COP measures of balance may identify subtle impairments not captured by the BESS.
Exercise Combined With Ultrasound Attenuates Neuropathic Pain in Rats Associated With Downregulation of IL-6 and TNF-α, but With Upregulation of IL-10
Authors: Huang Po-Ching , Tsai Kun-Ling , Chen Yu-Wen , Lin Heng-Teng , Hung Ching-Hsia 
Published: March 2017

BACKGROUND:
Although there are several evidences that suggest efficacies of therapeutic ultrasound (TU) or treadmill exercise (TE) to alleviate nerve injury—associated pain, molecular mechanisms are less clear. We aimed to investigate the impact of TU and/or TE on neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve and their roles of proinflammatory and anti-inflammatory cytokines.

METHODS:
Rats were randomly divided into (n = 10 per group) sham operation (sham), CCI procedure followed by false application of TU (CCI + TU0), CCI procedure followed by false application of TU and TE (CCI + TU0 + TE), CCI, and CCI procedure followed by TU alone (CCI + TU), TE alone (CCI + TE), or both TU and TE (CCI + TU + TE) groups. TU and TE were administered daily, starting on postoperative day 8 (POD 8) for 3 weeks. Mechanical and thermal hypersensitivity, tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and IL-6 in the sciatic nerve were assessed on PODs 14 and 28. Data were analyzed by 1-way, 2-way, or 3-way analysis of variance of repeated measures or 1-way analysis of variance.

RESULTS:
After the interventions, there was statistical significance (all P ≤ .0001) between the groups for all outcome parameters, all in favor of the experimental group: 4.2 for mean mechanical withdrawal thresholds (95% confidence interval, 1.8–7.6) and 4.8 for mean thermal withdrawal latencies (95% confidence interval, 2.2–8.1). TU and/or TE provoked an increase in mechanical withdrawal thresholds and thermal withdrawal latencies in CCI rats. TU + TE was more effective to reverse pain hypersensitivity than having each treatment alone. On PODs 14 and 28, the CCI rats exhibited an upregulation of sciatic TNF-α and IL-6 expression, whereas TU or TE alone or TU + TE combination prevented the upregulation. TU and/or TE also showed the upregulation of less IL-10 expression in the sciatic nerve.

CONCLUSIONS:
We found that TU + TE is better than TU or TE alone for treating neuropathic pain. TU and/or TE for pain management may be straightly associated with less TNF-α and IL-6 expression and more IL-10 expression.
Recombinant Factor VIIa Is Associated With Increased Thrombotic Complications in Pediatric Cardiac Surgery Patients
Authors: Downey Laura , Brown Morgan L. , Faraoni David , Zurakowski David , DiNardo James A. 
Published: March 2017

BACKGROUND:
Recombinant factor VIIa (rFVIIa) is routinely used as an off-label hemostatic agent in children undergoing cardiac surgery. Despite evidence that rFVIIa use is associated with an increased incidence of thrombotic complications in adult cardiac surgery, the safety of rFVIIa as a rescue hemostatic agent in the pediatric cardiac surgical population is less definitively delineated. In this retrospective study, we used propensity score matching to compare the incidence of thrombotic complications between children treated with rFVIIa and their matched controls.

METHODS:
We retrospectively reviewed medical records and pharmacy data from all neonates and children who underwent congenital cardiac surgery between May 1, 2011, and October 31, 2013, at Boston Children’s Hospital, and identified those who received rFVIIa during the perioperative period. Using existing knowledge, we chose 10 factors associated with bleeding after cardiac surgery to be used in our propensity score: age, sex, body weight, neonates, prematurity, previous sternotomy, cardiopulmonary bypass time, deep hypothermic circulatory arrest time, aortic cross-clamp time, and the operative surgeon. We then used propensity-matched analysis to match children treated with rFVIIa with 2 controls. The primary outcome was thrombotic complications. Secondary outcomes included reexploration for bleeding, length of cardiac intensive care unit stay, length of hospital stay, and 30-day mortality.

RESULTS:
One hundred forty-nine patients received perioperative rFVIIa during the study period. Propensity matching yielded 143 rFVIIa patients matched to 2 control patients each (n = 286). Three control patients were found to have received rFVIIa during the perioperative course and were removed from the analysis, for a total of 283 control patients. The administration of rFVIIa was associated with an increased incidence of thrombotic complications (20% vs 8%; odds ratio [OR]: 3.9 [95% confidence interval {CI}: 2.6–5.9], P < .001). Administration of rFVIIa was associated with a prolonged median length of cardiac intensive care unit stay (8 days [interquartile range {IQR}: 4–24] vs 5 days [IQR: 2–10], P < .001) and prolonged length of hospital stay (20 [IQR: 9–44] vs 11 days [IQR: 7–23], P < .001). No difference in reexploration for bleeding (rFVII = 14% vs controls = 9%; OR: 1.7 [95% CI, 0.92–3.1], P = .12) or 30-day mortality was observed (8% vs 6%; OR 1.3 [95% CI, 0.60–2.89], P = .51).

CONCLUSIONS:
This retrospective analysis confirmed that perioperative administration of rFVIIa is associated with an increased incidence of postoperative thrombotic complications in neonates and children undergoing cardiac surgery, without increase in 30-day mortality. In conclusion, rFVIIa should be used with extreme caution in pediatric patients undergoing cardiac surgery.
Structural and functional impact of SNPs in P-selectin gene: A comprehensive in silico analysis
Authors: Kaur Raminderjit , Singh Jatinder , Kaur Manpreet 
Published: March 2017

AbstractP-selectin is an adhesion molecule which plays an important role in the development of inflammation. It is encoded by the SELP gene located on chromosome 1q21-q24. Various single nucleotide polymorphisms (SNPs) ofSELPhave been reported to be associated with various inflammatory disease conditions. The genetics behind these diseases could be better understood by knowing the structural and functional impact of various genetic determinants ofSELP. So far, this is the first comprehensive and systematicin silicoanalysis of SNPs inSELP. A total of 2780 SNPs ofSELPwere retrieved from NCBI dbSNP. Only conserved and validated SNPs with minor allele frequency (MAF) ≥ 0.05 were subjected to further analysis. Based on these criteria, we selected 4 non-synonymous SNPs (nsSNPs) and 119 non-coding SNPs (ncSNPs). The nsSNPs were analyzed for deleterious effects using SIFT, Polyphen-2, nsSNPAnalyzer, SNP & Go, SNPs3, Mutperd and I-mutant web tools. The template prediction for variant structure modeling was performed using MUSTER and SWISS-MODEL. The functional impact of ncSNPs was analyzed by SNPinfo and RegulomeDB. Thein silicoanalysis predicted 3 nsSNPs and 21 ncSNPs as potential candidates for future case-control association studies and functional analysis ofSELP.
An update on HLA alleles associated with adverse drug reactions
Authors: Fricke-Galindo Ingrid , LLerena Adrián , López-López Marisol 
Published: March 2017

Abstract
Adverse drug reactions (ADRs) are considered as an important cause of morbidity and mortality. The hypersensitivity reactions are immune-mediated ADRs, which are dose-independent, unpredictable and have been associated with several HLA alleles. The present review aimed to describe HLA alleles that have been associated with different ADRs in populations worldwide, the recommendations of regulatory agencies and pharmacoeconomic information and databases for the study of HLA alleles in pharmacogenetics. A systematic search was performed in June 2016 of articles relevant to this issue in indexed journals and in scientific databases (PubMed and PharmGKB). The information of 95 association studies found was summarized. Several HLA alleles and haplotypes have been associated with ADRs induced mainly by carbamazepine, allopurinol, abacavir and nevirapine, among other drugs. Years with the highest numbers of publications were 2013 and 2014. The majority of the reports have been performed on Asians and Caucasians, and carbamazepine was the most studied ADR drug inducer. Two HLA alleles’ databases are described, as well as the recommendations of the U.S. Food and Drug Administration, the European Medicine Agency and the Clinical Pharmacogenetics Implementation Consortium. Pharmacoeconomic studies on this issue are also mentioned. The strongest associations remain for HLA-B*58:01, HLA-B*57:01, HLA-B*15:02 and HLA-A*31:01 but only in certain populations; therefore, studies on different ethnic groups would be useful. Due to the improvement of drug therapy and the economic benefit that HLA screening represents, investigations on HLA alleles associated with ADR should continue.
2D NMR characterization of wheat straw residual lignin after dilute acid pretreatment with different severities
Authors: Jensen Anders , Cabrera Yohanna , Hsieh Chia-Wen , Nielsen John , Ralph John , Felby Claus 
Published: March 2017

Abstract
The chemical characteristics of wheat straw lignin pretreated under dilute acid conditions were compared. After pretreatment, the lignin content of the solid residue increased as temperature increased (from 160°C to 190°C) and with the amount of acid added (0%, 0.25%, or 1% H2SO4). Pretreatment at 190°C with increasing concentrations of acid catalyst led to a decrease in glucan content, whereas the glucan content remained almost constant at 160°C pretreatment regardless of the acid concentration. The xylan content decreased in proportion with increased acid concentration and pretreatment temperature. The residual lignins were characterized by solution-state, two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy and size-exclusion chromatography (SEC). Results showed that more ether bonds were cleaved with increased pretreatment temperature and lower pH, whereas the levels of carbon-carbon bonded structures (e.g. phenylcoumaran and resinol units) were hardly affected. With a pretreatment of 160°C and 1% H2SO4, the majority of the β-O-4 bonds were cleaved. In addition, lignin depolymerization was more evident than repolymerization at higher pretreatment temperatures and lower pH. Documenting lignin structural changes as a function of pretreatment parameters provides a tool for biorefineries to gain flexibility in processing parameters with full control over the final properties of the products.
Use of the sternocleidomastoid flap in association with a dermal regeneration template and a skin graft in the temporal region reconstruction
Authors: Bocchiotti Maria Alessandra , Raimondo Luca , Germano Silvia , Ruka Erind , Frenello Ambra , Garzaro Massimiliano , Pecorari Giancarlo 
Published: March 2017

AbstractSince its first description in 1908, the sternocleidomastoid flap (SCM) has gained popularity in head-and-neck reconstruction as a regional flap. We reported a 69-year-old Caucasian male who was evaluated in our clinic for a large, bloody, esophitic, and ulcerated lesion of the right temporoparotideal region associated with several actinic keratoses of the head skin. After resection of the tumor, taking into consideration the patient’s comorbidities and surgical defect characteristics, we decided to use the SCM flap for the reconstruction. The SCM flap was harvested as a muscular flap to avoid as possible skin paddle necrosis due to the poor conditions of the patient’s vessels. Moreover, considering the surgical site depth and to prevent a postsurgical excessive scar retraction, the muscle was covered with Integra®Dermal Regeneration Template single layer and a skin graft was harvested from the left thigh. The follow-up at 1 year confirmed that both oncological and reconstructive goals were successfully achieved. In our experience, the SCM flap in association with a dermal regeneration template and a skin graft can be considered as a reliable and possible option in temporal region reconstruction when local or systemic conditions of the patient do not permit other reconstructive options.
Ameliorative potential of Blighia sapida K.D. Koenig bark against pancreatic β-cell dysfunction in alloxan-induced diabetic rats
Authors: Ojo Oluwafemi Adeleke , Ajiboye Basiru Olaitan , Ojo Adebola Busola , Oyinloye Babatunji Emmanuel , Imiere Oluwatosin Debbie , Adeyonu Oluwatosin 
Published: March 2017

Abstract

Background
In West Africa, the fruit, seed, leaf and stem of Blighia sapida K.D. Koenig are commonly used as remedy against a variety of diseases, including diabetes mellitus. This study investigated the ameliorative potential of B. sapida K.D. Koenig stem bark ethanol extract against pancreatic β-cell dysfunction in diabetic rats.

Methods
Diabetes was induced by intraperitoneal injection of alloxan (65 mg/kg body weight) for 21 days, and orally administered with glibenclamide (5 mg/kg body weight), 50–150 mg/kg body weight of B. sapida stem bark ethanol extract once daily for 21 days.

Results
The blood glucose levels of rats induced with alloxan were significantly and gradually reduced (p<0.05) in B. sapida stem bark ethanol extract treated animals at the dose of 50–150 mg/kg body weight, and in glibenclamide-treated animals. The significant increase in the lipid peroxidation (malonaldehyde), homeostasis model assessment-insulin resistance scores (HOMA-IR) and decrease in serum insulin, pancreatic β-cell scores as well as antioxidant marker enzymes in untreated diabetic rats compared to normal control rats were reversed by the B. sapida stem bark ethanol extract and glibenclamide. Similarly, histopathological changes in the pancreas were also reversed by the extract and glibenclamide. However, these effects were most prominent in the animals treated with 150 mg/kg body weight of B. sapida bark.

Conclusions
These findings indicate that B. sapida stem bark possess anti-hyperglycemic activity and exhibits ameliorative potential in managing diabetes.
PhD supervision meetings in an English as a Lingua Franca (ELF) setting: linguistic competence and content knowledge as neutralizers of institutional and academic power
Authors: Björkman Beyza 
Published: March 2017

Abstract
The present paper investigates PhD supervision meetings, using material from naturally occurring speech of ten hours by PhD supervisors and students who all use English as a lingua franca (ELF) for research purposes. The recordings have been transcribed in their entirety, with conversation analytical procedures and additional ethnographic interviews with the PhD supervisors. The present paper is a follow-up to the two previous studies by the author (in European Journal for Applied Linguistics 3[2], 2015, and The Routledge Handbook of English for Academic Purposes, 2016) and focuses on linguistic competence and content knowledge as factors possibly mitigating the power asymmetry present in the interactions. The findings show no observable power asymmetries manifested in the interactions or in the interview responses by the supervisors. The analyses showed that the supervisors’ and the students’ level of linguistic competence seemed very similar, which was further supported by the supervisors’ self-reports of their own English and their informal evaluations of their students’ levels of proficiency. When it comes to content knowledge, the students overall showed very good command of their subjects, disciplinary conventions and their projects in general, further supported by their supervisors’ evaluations in the interview data. Based on these findings, it is suggested here that in ELF interactions of this particular type where the speakers have similar levels of linguistic competence and content knowledge, power asymmetries become less visible.
Screening for Chronic Kidney Disease in Adult Males in Vojvodina: A Cross-Sectional Study
Authors: Čabarkapa Velibor , Ilinčić Branislava , Đerić Mirjana , Radosavkić Isidora , Špovac Mirko , Sudji Jan , Petrović Veljko 
Published: March 2017

SummaryBackground: Chronic kidney disease (CKD) is one of the most significant global health problems accompanied by numerous complicatons, with constant increase in the number of affected people. This number is much higher in early phases of disease and patients are mostly asymptomatic, so early detection of CKD is crucial. The aim was examination of the prevalence of CKD in the general population of males in Vojvodina, based on estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR), and exploring the determinants and awareness of CKD.Methods: This cross-sectional study included 3060 male examinees from the general population, over 18 years of age, whose eGFR and ACR were calculated, first morning urine specimen examined, arterial blood pressure measured and body mass index calculated. Standard biochemistry methods determined creatinine, urea, uric acid and glucose serum concentrations as well as albumin and creatinine urine levels.Results: Prevalence of CKD in the adult male population is 7.9%, highest in men over 65 years of age (46.7%), while in the other age groups it is 3.6-12.6%. The largest number of examinees with a positive CKD marker suffer from arterial hypertension (HTA) and diabetes mellitus (DM). Only 1.3% of examinees with eGFR<60 ml/min/1.73 m2 and/or ACR≥ 3 mg/mmol had been aware of positive CKD biomarkers.Conclusions: Obtained results show the prevalence of CKD in adult males is 7.9%, HTA and DM are the most important CKD risk factors and the level of CKD awareness is extremely low (1.3%) indicating the necessity for introduction of early stage disease recognition measures, including raising CKD awareness.