bluuebunny/crossref_metadata_2025_split huggingface dataset:
A atuação do Montepio na produção estatal de habitação em João Pessoa de 1932 a 1963
Authors: Nunes Angela Araujo 
Published: January 2017

Este trabalho objetiva o exame da atuação da Carteira Imobiliária do Montepio do Estado da Paraíba na produção estatal de habitação na cidade de João Pessoa, de 1932 a 1963, período entre a designação da instituição para a produção de moradias em benefício do funcionalismo público até sua última realização antes da criação do BNH. Através de exaustiva pesquisa documental, realizada em acervos locais, e tendo como principal fonte o jornal A União, registro oficial das realizações do Executivo estadual, foram recolhidos dados sobre as realizações habitacionais do instituto, possibilitando a identificação das suas vilas e conjuntos populares e, posteriormente, a classificação das unidades construídas e a reconstituição da planta e fachada originais. Palavras-chave: Montepio; João Pessoa; carteira imobiliária; habitação popular. Abstract: This work analyzes the constructive actuations of the real estate portfolio of Montepio Paraíba State in the statal housing production in the city of João Pessoa, from 1932 to 1963, established between the institutional designation for the production of housing in benefit of the public functionalism and its last popular realization before the work of BNH. Through exhausting documental research, done in local collections and especially through the newspaper A União, official record of the realizations of the state executive, data was found regarding the realizations of the housings by the institution, identifying the cities and popular aggregation and later on classifying the built unities and the reconstitution of thehouse plans and the front elevation. Keywords: Montepio; João Pessoa; real estate portfolio; popular housing.
Spectrum of Congenital Heart Diseases in Eastern Nepal: A tertiary care hospital experience
Authors: Shah Prashant , Sherpa Kunjang , Pandey Naveen Kumar , Manandhar Bhawani , Dhungana Sahadeb Prasad 
Published: January 2017

Background & Objectives: Congenital heart diseases are neglected especially in world’s poorest nations and appear to be ignored and unexplored dimension of health. The exact prevalence and spectrum of congenital heart diseases in Nepal is largely unknown. The aim of this study was to describe the local experience on the magnitude and the pattern of congenital heart disease in order to increase the awareness of the public and health policy makers on its burden in Nepal.Materials & Methods: This is an observational hospital based study carried out in a tertiary care hospital in Eastern Nepal. The duration of this study was from April 2015 to July 2016. The echocardiography reports of all patients clinically suspected of having congenital heart disease were retrieved, and their diagnostic details were extracted. Only patients of day one of life to 14 years of age were included. Congenital heart diseases like bicuspid aortic valve, mitral valve prolapse and various inherited cardiomyopathies were excluded.Results: A total of 330 echocardiograms were performed for clinically suspected congenital heart disease. The mean age of study population was 22.31±34.08 months with male to female ratio of 1.2:1. 23% of clinically suspected congenital heart disease cases turned out to have normal echocardiography. Acyanotic congenital heart disease was most common (81.5%) followed by cyanotic congenital heart disease (14.2%) and obstructive congenital heart disease (4.3%). Atrial septal defect was found to be the most common form of acyanotic congenital heart disease (52%) which was followed by ventricular septal defect (28.8%) and patent ductus arteriosus (14.8%). Tetralogy of Fallot and double outlet right ventricle were the most common form of cyanotic CHD representing 44.4% of all cyanotic patients. Pulmonary stenosis was the most common obstructive congenital heart disease observed in this study population (63.6%). Rarer entities, like d-transposition of great arteries, congenitally corrected transposition of great arteries, various types of total anomalous pulmonary venous drainage, double inlet left ventricle, interrupted aortic arch, Shone complex, etc. were also observed, however represented only the minority of the study population.Conclusion: The spectrum of congenital heart disease seen in this study very likely and only represents the tip of the iceberg. Public awareness programmes and training of health care personnel needs to be emphasized in order to facilitate its early diagnosis and improve its outcome.
La dragonnade du Poitou et l’exil des huguenots dans la littérature de controverse anglaise
Authors: Dunan-Page Anne 
Published: January 2017

Résumé À l’été 1681 fait rage la “dragonnade du Poitou”, un épisode crucial dans l’histoire du protestantisme français. Certains huguenots quittent alors la France pour l’Angleterre, terre protestante où ils espérent trouver refuge. Cet article examine la façon dont la dragonnade a été représentée dans la presse anglaise et dans la littérature de controverse et comment ces représentations ont influencé les conditions d’accueil des exilés. Alors que l’Angleterre sortait péniblement de la “crise de l’Exclusion” qui visait à empêcher le catholique duc d’York (futur Jacques II) de succéder à son frère Charles II, nous démontrons comment l’exil des Huguenots a été mis en scène par les deux grandes factions, Whig et Tory, à des fins de propagande. Nous nous interrogeons notamment sur la façon dont les auteurs ont manipulé les positions huguenotes pour raviver la querelle sur le futur du protestantisme en Angleterre et l’absolutisme Stuart.
Associer science et politique
Authors: Lantz Pierre , Flocco Gaëtan 
Published: January 2017

Gaëtan Flocco interviewe Pierre Lantz, philosophe et sociologue, qui a fait partie des pionniers de la revue L’homme et la société . L’échange restitué ici est l’occasion de revenir sur les origines de la revue, ses objectifs politiques et théoriques, ses conditions de création et de fonctionnement ou encore ses figures marquantes. Le récit circonstancié de Pierre Lantz permet en particulier d’appréhender les évolutions notables subies par L’homme et la société au cours de ces cinquante années. D’abord, sur le plan institutionnel, en se dotant par exemple d’un comité de rédaction comprenant de nombreux membres ; mais aussi sur un plan plus théorique et thématique, en s’ouvrant notamment à d’autres influences que le marxisme. Ces multiples inflexions ont eu lieu sans pour autant renoncer à ce qui semble avoir été la marque de fabrique de la revue dès ses débuts, celle d’allier la science et le politique, c’est-à-dire d’orienter la compréhension du monde dans la perspective de son émancipation.
L’ardeur et la lumière
Authors: Pérez Joseph 
Published: January 2017

Les trois grâces que Thérèse déclare avoir reçues de Dieu (l’expérience mystique, le discernement, le don d’expression) illustrent ce qu’on a pu appeler la lutte d’un esprit contre un tempérament : la raison l’emporte sur la passion qu’elle se soumet et qu’elle discipline.
La passion selon Thérèse d’Avila
Authors: Kristeva Julia 
Published: January 2017

À partir de la fiction d’un personnage, Sylvia Leclercq, psychanalyste, psychothérapeute et critique littéraire, comme elle, Julia Kristeva, rencontre à un moment critique de sa propre vie, la figure de Thérèse d’Avila, qui lui apparaît rassembler en elle les valeurs de la culture européenne, essentiellement plurielles et notamment juives et chrétiennes. La jouissance féminine dont relèvent la mystique de Thérèse, son expérience « extravagante » de Dieu, qui la conduit à des extases et des divisions, sont l’objet d’une analyse doublement menée dans les domaines de la psychanalyse et de la critique littéraire, conduisant à une identification des jeux de l’écriture et de la transmission.
AS VIOLÊNCIAS INSTITUCIONAL E ESTRUTURAL VIVENCIADAS POR MORADORAS DE RUA
Authors: De Antoni Clarissa , Munhós Aline Assmass Ruas 
Published: January 2017

A presença de mulheres moradoras de rua é uma realidade crescente no Brasil e há escassos estudos sobre esse fenômeno, principalmente os que evidenciam os fatores de risco enfrentados pelas mesmas. Este estudo investigou a percepção de moradoras de rua da cidade Porto Alegre, Brasil, sobre a violência que vivenciaram em seus sistemas ecológicos, por meio da Teoria Bioecológica do Desenvolvimento Humano. Trata-se de um estudo qualitativo de cunho exploratório, no qual seis participantes foram entrevistadas. Os dados foram submetidos à análise de conteúdo, e emergiram duas categorias: violência institucional e a violência estrutural. Essas violências estão presentes em todos os contextos ecológicos (micro-, meso-, exo- e macrossistema). Na institucional, evidenciou-se principalmente aquela perpetrada por profissionais vinculados a instituições públicas; e na estrutural, relacionada às diferentes formas de manutenção das desigualdades sociais, culturais, de gênero, etárias e étnicas que produzem a miséria, a fome e as várias formas de submissão e exploração de umas pessoas pelas outras. Conclui-se que a existência de múltiplas formas de violência leva a situações de vulnerabilidade que agravam ainda mais o quadro de miserabilidade a que estão expostas e a qualidade de vida dessas moradoras. Além disso essas violências oprimem sua individualidade, seus desejos e necessidades.
FITOTOXICIDADE DE EXTRATOS DE Dasyphyllum tomentosum (Spreng). Cabrera
Authors: PAULA Cristiane Da Silva , MIGUEL Obdúlio Gomes , MIGUEL Marilis Dallarmi 
Published: January 2017

Este trabalho visou avaliar a ação fitotóxica de extrato e frações obtidas da casca do caule de Dasyphyllum tomentosum sobre a atividade das enzimas α-amilase, catalase, peroxidase, polifenoloxidase e superóxido dismutase em plântulas de alface (Lactuca sativa, var Grand rapis). Sementes de alface foram expostas às concentrações de 250, 500 e 1000 µg.mL-1do extrato de D. tomentosum e frações do mesmo, em condições ambientais controladas. No sétimo dia após germinação, as amostras foram submetidas à avaliação da atividade enzimática utilizando técnica específica para cada enzima e leitura espectrofotométrica. O efeito sobre as enzimas que demonstram alterações no sistema de defesa antioxidante de L. sativa mostram que o extrato bruto e frações alteraram a produção das enzimas α- amilase, peroxidase, catalase e polifenol oxidase em, ao menos, uma das concentrações testadas, sendo um indicativo de estresse que interfere na divisão celular. Os resultados obtidos apontam para a presença de compostos com atividade inibidora ou estimulatória nas cascas de D. tomentosum revelando potencial fitotóxico sobre as plântulas de alface.
Osmolyte regulation by TonEBP/NFAT5 during anoxia-recovery and dehydration–rehydration stresses in the freeze-tolerant wood frog (Rana sylvatica)
Authors: Al-attar Rasha , Zhang Yichi , Storey Kenneth B. 
Published: January 2017

BackgroundThe wood frog,Rana sylvatica, tolerates freezing as a means of winter survival. Freezing is considered to be an ischemic/anoxic event in which oxygen delivery is significantly impaired. In addition, cellular dehydration occurs during freezing because water is lost to extracellular compartments in order to promote freezing. In order to prevent severe cell shrinkage and cell death, it is important for the wood frog to have adaptive mechanisms for osmoregulation. One important mechanism of cellular osmoregulation occurs through the cellular uptake/production of organic osmolytes like sorbitol, betaine, and myo-inositol. Betaine and myo-inositol are transported by the proteins BGT-1 and SMIT, respectively. Sorbitol on the other hand, is synthesized inside the cell by the enzyme aldose reductase. These three proteins are regulated at the transcriptional level by the transcription factor, NFAT5/TonEBP. Therefore, the objective of this study was to elucidate the role of NFAT5/TonEBP in regulating BGT-1, SMIT, and aldose reductase, during dehydration and anoxia in the wood frog muscle, liver, and kidney tissues.MethodsWood frogs were subjected to 24 h anoxia-4 h recovery and 40% dehydration-full rehydration experiments. Protein levels of NFAT5, BGT-1, SMIT, and aldose reductase were studied using immunoblotting in muscle, liver, and kidney tissues.ResultsImmunoblotting results demonstrated downregulations in NFAT5 protein levels in both liver and kidney tissues during anoxia (decreases by 41% and 44% relative to control for liver and kidney, respectively). Aldose reductase protein levels also decreased in both muscle and kidney tissues during anoxia (by 37% and 30% for muscle and kidney, respectively). On the other hand, BGT-1 levels increased during anoxia in muscle (0.9-fold compared to control) and kidney (1.1-fold). Under 40% dehydration, NFAT5 levels decreased in liver by 53%. Aldose reductase levels also decreased by 42% in dehydrated muscle, and by 35% in dehydrated liver. In contrast, BGT-1 levels increased by 1.4-fold in dehydrated liver. SMIT levels also increased in both dehydrated muscle and liver (both by 0.8-fold).DiscussionOverall, we observed that osmoregulation through an NFAT5-mediated pathway is both tissue- and stress-specific. In both anoxia and dehydration, there appears to be a general reduction in NFAT5 levels resulting in decreased aldose reductase levels, however BGT-1 and SMIT levels still increase in certain tissues. Therefore, the regulation of osmoregulatory genes during dehydration and anoxia occurs beyond the transcriptional level, and it possibly involves RNA processing as well. These novel findings on the osmoregulatory mechanisms utilized by the wood frog advances our knowledge of osmoregulation during anoxia and dehydration. In addition, these findings highlight the importance of using this model to study molecular adaptations during stress.
Advanced Hierarchical Computational Modeling‐Based Rational Development of Platinum (II) Nanocomplex to Improve Lung Cancer Therapy
Authors: Huang Haozhe , Ji Beihong , Huang Yixian , Li Shichen , Luo Zhangyi , Chen Shangyu , Li Sihan , Chen Yuang , Bain Daniel J. , Sun Jingjing , Yang Da , Burns Timothy F. , Wang Junmei , Li Song 
Published: September 2024

AbstractCancer stem cells (CSCs) are known to be one of the determining factors that contribute to therapeutic resistance. However, much remains to be understood about the reprogramming network leading to the generation of CSCs driven by chemotherapy. In this study, guided by bioinformatics study, deeper insight is uncovered and provided into the CSC enrichment mechanism driven by cisplatin (CDDP) treatment. It is discovered that CDDP can repopulate the level of CSC by activating AKT1 oncogenic pathway that is further enhanced by COX‐2 inflammatory signaling. Simultaneously blocking these two pathways can synergistically restrain the number of CSCs. Under the guidance of advanced hierarchical computational modeling, including molecular docking, molecular dynamics (MD) simulation and binding free energy analysis, MK‐2206 is selected as the AKT1 inhibitor to achieve optimal codelivery of CDDP, MK‐2206 and 5‐ASA (COX‐2 inhibitor) through 5‐ASA‐derivatized dual functional immunostimulatory nanocarrier (PASA). This triple combination (PASA/CDDP/MK‐2206) significantly reduces tumor burden in both orthotopic and metastatic lung cancer models. Mechanistic studies show that this improved therapeutic activity is due to elimination of CSCs and reversal of the immunosuppressive tumor microenvironment. This study suggests that PASA/CDDP/MK‐2206 may represent a simple and effective lung cancer therapy via reversing CSCs‐associated chemoresistance.
Carbon Dot‐Based Smart Soil with Automatically Adjustable Porosity and Aggregate Size
Authors: Niu Qianjie , Jiang Jiwei , Zhan Changsong , Tao Yujie , Ye Zijun , Huang Jian , Dong Bin , Kang Zhenhui 
Published: September 2024

AbstractWith the world's population expanding rapidly, modern agriculture is evolving at a swift pace, leading to a significant increase in food production, primarily through the use of chemical fertilizers. However, this heavy reliance on fertilizers has led to issues such as soil compaction and decrease of earthworm abundance. Herein this study reports a smart soil consisting of conventional soil and carbon dots (CDot) based smart material which is capable of automatically adjusting its porosity and soil aggregate size. Due to the responsiveness, The CDot‐based smart soil can lift its height up to 150% upon humidity stimulation due to the increased porosity which is similar to the effect caused by earthworms. Based on this effect, this smart soil can increase the growth rate of maize seedlings by 40%, thus showing great potentials in agriculture.
Direct Ionic Ink Writing on and Penetrating into Elastomer for Patternable, Waterproof, and Wear‐Resistant Ionic Circuits
Authors: An Yao , Wu Junshi , Xu Beihang , Zhu Jinghao , Ma Antong , Wang Wenjin , Yang Yongjia , Lian Xiaodong , Yang Zhaoxiang , Wang Yapei , He Yonglin 
Published: September 2024

AbstractThe increasing need for ionic circuits has driven the demand for patterning methods with excellent wear resistance and ease of preparation. However, the traditional method of the circuits modified on the surface frequently suffers from wear and detachment during use. Herein, an interpenetrating network of poly(ionic liquid) and polyurethane is employed, creating a patternable ionic circuit that can resist the abrasion of sandpaper or taping. Hydrophobic ionic liquids are successfully polymerized inside the polyurethane to achieve a waterproof ionic circuit, simultaneously reducing the impact of environmental humidity. Additionally, this ionic circuit possesses the capability to perceive the multisignals of temperature, pressure, and pressing shapes with the assistance of artificial intelligence. The interpenetrating network provides a simple and practical solution for the fabrication of wear‐resistant and stable patterned ionic circuits.
Low‐Temperature and Fast‐Charging Sodium Metal Batteries Enabled by Molecular Structure Regulation of Fluorinated Solvents
Authors: Gao Yiwen , Wang Zhicheng , Tu Haifeng , Xue Jiangyan , Weng Shixiao , Lu Suwan , Liu Lingwang , Sun Guochao , Peng Keyang , Zhang Xin , Li Dejun , Liu Yang , Xu Jingjing , Li Hong , Wu Xiaodong 
Published: September 2024

AbstractReversible cycling of sodium metal batteries (SMBs) is limited by Na dendrite growth, unstable solid‐electrolyte interphase (SEI) formation, and poor Na+ transport/de‐solvation kinetics, especially under the conditions of low‐temperature and fast‐charging. Here, a series of electrolytes for low‐temperature and fast‐charging SMBs by regulating the molecular structure of solvents is presented, in which ethyl acetate (EA) is selected as a baseline solvent, ethyl difluoroacetate (EDFA) and 2,2‐difluoroethyl acetate (DFEA) solvents are obtained by introducing difluorination group into EA molecule at different positions. It is found that the difluorination at the space‐position of oxygen in DFEA causes the lowest binding energy with Na+, which brings faster Na+ transport/de‐solvation ability in DFEA‐based electrolytes. In addition, more ionic aggregates (AGGs) structures are also observed in DFEA‐based electrolytes, leading to a stable inorganic‐rich SEI layer formed on the Na‐metal surface. Therefore, the optimal DFEA‐based electrolyte shows prolonged cycle life (>1500 h) in Na||Na cell and evidently improves cycle performance in the Na3V2(PO4)3 (NVP)||Na cell at −20 °C, achieving high discharge capacity (93.64 mAh g−1 at 0.5C) and ultra‐stable capacity retention (99.27% after 400 cycles). Furthermore, the NVP||Na cell also reveals outstanding fast‐charging ability at room temperature, showing capacity retention of 81.84% at 10C over 1000 cycles.
Oxidized Carbon Nanoparticles Enhance Cellular Energetics With Application to Injured Brain
Authors: Mouli Karthik , Liopo Anton V. , McHugh Emily A. , Underwood Erica , Zhao Jing , Dash Pramod K. , Vo Anh T. T. , Malojirao Vikas H. , Hegde Muralidhar L. , Tour James M. , Derry Paul J. , Kent Thomas A. 
Published: September 2024

AbstractPro‐energetic effects of functionalized, oxidized carbon nanozymes (OCNs) are reported. OCNs, derived from harsh acid oxidation of single‐wall carbon nanotubes or activated charcoal are previously shown to possess multiple nanozymatic activities including mimicking superoxide dismutase and catalyzing the oxidation of reduced nicotinamide adenine dinucleotide (NADH) to NAD+. These actions are predicted to generate a glycolytic shift and enhance mitochondrial energetics under impaired conditions. Impaired mitochondrial energy metabolism is increasingly recognized as an important facet of traumatic brain injury (TBI) pathophysiology and decreases the efficiency of electron transport chain (ETC)‐coupled adenosine triphosphate (ATP) and NAD+ regeneration. In vitro, OCNs promote a pro‐aerobic shift in energy metabolism that persists through ETC inhibition and enhances glycolytic flux, glycolytic ATP production, and cellular generation of lactate, a crucial auxiliary substrate for energy metabolism. To address specific mechanisms of iron injury from hemorrhage, OCNs with the iron chelator, deferoxamine (DEF), covalently‐linked were synthesized. DEF‐linked OCNs induce a glycolytic shift in‐vitro and in‐vivo in tissue sections from a rat model of TBI complicated by hemorrhagic contusion. OCNs further reduced hemorrhage volumes 3 days following TBI. These results suggest OCNs are promising as pleiotropic mediators of cell and tissue resilience to injury.
Letrozole‐Based Near‐Infrared Dynamic Imaging Targeting Ductal‐Vascular RhoJ From Pancreatic Intraepithelial Neoplasia to Pancreatic Ductal Adenocarcinoma
Authors: Cao Zhi , Hu Zhuang , Wang Yishu , Zhao Fengyun , Li Jingmin , Li Ruihan , Hu Weibin , Liu Bei , Tang Shaohui , Wang Ping , Li Fugui , Chen Zilin , Wang Lisheng , Ma Xiaodong 
Published: September 2024

AbstractPancreatic ductal adenocarcinoma (PDAC) relies heavily on neoangiogenesis for its progression, making early detection crucial. Here, LTZi‐MHI148 (Letrozole inhibitor bonding with MHI‐148 dye), a near‐infrared (NIR) fluorescent agent is developed, to target RhoJ (Ras Homolog Family Member J), a protein expressed in neonatal vasculature, for both imaging and therapy of early PDAC. This agent is synthesized by conjugating Letrozole with MHI‐148, exhibiting excellent NIR characteristics and photostability. In vitro studies showed that LTZi‐MHI148 selectively accumulated within pancreatic cancer cells through Organic Anion Transporting Polypeptide (OATP) transporters and bound to cytoplasmic RhoJ. In vivo, the probe effectively targeted neoangiogenesis and Pancreatic Intraepithelial Neoplasias (PanINs) in various PDAC models, including the orthotopic, ectopic, spontaneous, and tamoxifen‐induced tumors. Notably, LTZi‐MHI148 detected preneoplastic PanIN lesions with Overexpressed RhoJ and active neoangiogenesis in both spontaneous and tamoxifen‐induced PDAC murine models. Longitudinal imaging studies revealed that RhoJ‐targeted neoangiogenesis tracks lesion progression, highlighting LTZi‐MHI148's utility in monitoring disease progression. Furthermore, multiple LTZi‐MHI148 administrations attenuated PanINs to PDAC progression, suggesting its potential as a therapeutic intervention. These findings underscore the translational potential of LTZi‐MHI148 for the early detection and targeted therapy of PDAC, utilizing NIR‐I/II imaging to monitor RhoJ overexpression in precancerous ductal neoplasia associated with neoangiogenesis.