bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legal Mobilization Networks and the LGBT Rights Revolution in Colombia (1992–2022): Using Litigation and Amicus Curiae Briefs in Rights Struggles
Authors: Jaramillo Juliana 
Published: October 2024

Abstract
Identifying what actors drive social change through the courts has been a central pursuit in the socio-legal literature. This article studies Colombia’s LGBT rights revolution (1992–2022) by focusing on the broad legal mobilization network that promoted these rights through litigation and amicus curiae briefs. While legal mobilization scholarship has traditionally explained significant legal reforms by focusing on social movements and their support structures, this study adopts a network approach to capture the diversity of both civil society and state actors involved in court-based rights struggles. Based on an original database of 133 rulings, interviews, and network analysis, this work shows the emergence of a broad and dense pro-LGBT network that played a crucial role in advancing LGBT rights and countering conservative-religious mobilization by exerting sustained pressure on judges, providing valuable information, and lending legitimacy to legal claims. This research demonstrates that a network approach contributes to developing a more comprehensive theory of the different actors, resources, and mobilizing structures that influence legal change.
Multidimensional analysis of matched primary and recurrent glioblastoma identifies contributors to tumor recurrence influencing time to relapse
Authors: Shekarian Tala , Ritz Marie-Françoise , Hogan Sabrina , Martins Tomás A , Schmassmann Philip , Gerber Alexandra , Roux Julien , Kaymak Deniz , Durano Célia , Burger Bettina , Matter Matthias , Hutter Gregor 
Published: October 2024

Abstract
Glioblastoma (GBM) is a lethal brain tumor without effective treatment options. This study aimed to characterize longitudinal tumor changes in order to find potentially actionable targets to prevent GBM relapse. We extracted RNA and proteins from fresh frozen tumor samples from patient-matched IDHwt WHO grade 4 primary (pGBM) and recurrent (rGBM) tumors for transcriptomics and proteomics analysis. A tissue microarray containing paired tumor samples was processed for spatial transcriptomics analysis. Differentially expressed genes and proteins between pGBM and rGBM were involved in synapse development and myelination. By categorizing patients into short (STTR) and long (LTTR) time-to-lapse, we identified genes/proteins whose expression levels positively or negatively correlated with TTR. In rGBM, expressions of Fcγ receptors (FCGRs) and complement system genes were negatively correlated with TTR, whereas expression of genes involved in DNA methylation was positively correlated with TTR. Spatial transcriptomics of the tumor cells showed enrichment of oligodendrocytes in rGBM. Besides, we observed changes in the myeloid compartment such as a switch from quiescent to activated microglia and an enrichment in B and T cells in rGBM with STTR. Our results uncover a role for activated microglia/macrophages in GBM recurrence and suggest that interfering with these cells may hinder GBM relapse.
Surgical treatment of coexisting intra and extralobar sequestration in an infant
Authors: Saleh Ahmad , Awwad Adam , Bhattacharyya Ratul , Bhattacharyya Nishith 
Published: October 2024

Abstract
Pulmonary sequestration is a rare congenital malformation in which a nonfunctional segment of lung tissue has no communication with the tracheobronchial tree and does not participate in gas exchange. We present a rare case of a 20-month old female with extralobar pulmonary sequestration that was diagnosed at birth. The patient was also found to have a coexisting intralobar sequestration, found during surgery.
Molecular line lists for the singlet states in gaseous YN at high temperature
Authors: Farhat Ayman , Hammoud Sami 
Published: October 2024

ABSTRACT
Our aim in this study is to investigate the electronic structure of the gaseous YN molecule and provide an accurate molecular line list of spectroscopic transitions between the five lowest singlet states. The calculations were done by using large basis set for yttrium aug-cc-pVQZ-PP with relativistic effective core potentials at the spin-free level. We first used the method of complete active space self-consistent field, which was followed by the multireference singles and doubles configuration interaction. Potential energy curves and permanent and transition dipole moments were calculated at the internuclear distance range of 1.3–2.96 Å. For each state, we calculated the spectroscopic constants (Te, ωe, ωexe, ωeye, Be, αe, Re). The calculated values of the spectroscopic constants are in excellent agreement with the experimental constants available, with a relative difference of less than 5 cm−1. We further calculated the transition intensities of allowed transitions, and we provided the absorption spectra up to a temperature of 4000 K. The computed molecular line list contains 2.6 million transitions calculated between almost 18 186 vibro-rotational energy levels. It covers the frequency range between 0 and 30 000 cm−1. The effect of temperature on the spectra of hot YN was investigated with partition functions calculated between 298 and 4000 K. This study should help in identifying the singlet state spectrum of the hot YN molecule, which is possibly found in the atmospheres of cool stars and hot rocky super-Earths.
Generalized linear model study of the T90–T50 relation of gamma-ray bursts
Authors: Dutta Sourav , Sunanda  , Moharana Reetanjali , Kumar Manish 
Published: October 2024

ABSTRACT
Gamma-ray bursts (GRBs) can be studied with their linearly dependent parameters alongside the standard $T_{90}$ distribution. The generalized linear model (GLM) identifies the number of linear dependences in a two-parameter space. Classically, GRBs are classified into two classes by the presence of bimodality in the histogram of $T_{90}$. However, additional classes and different features of GRBs are fascinating topics to explore. In this work, we investigate GRB features in the $T_{90} {-}T_{50}$ plane using the GLM for three major catalogues: Swift, the Fermi Gamma-ray Burst Monitor (GBM), and the Burst And Transient Source Experiment (BATSE). This study shows five linear features for the Fermi GBM catalogue and four linear features for the BATSE catalogue, directing us towards the possibility of non-Gaussianity in the light curves of GRBs.
A two-minute burst of highly polarized radio emission originating from low Galactic latitude
Authors: Dobie Dougal , Zic Andrew , Oswald Lucy S , Pritchard Joshua , Lower Marcus E , Wang Ziteng , Qiu Hao , Hurley-Walker Natasha , Wang Yuanming , Lenc Emil , Kaplan David L , Anumarlapudi Akash , Auchettl Katie , Bailes Matthew , Cameron Andrew D , Cooke Jeffrey , Deller Adam , Driessen Laura N , Freeburn James , Murphy Tara , Shannon Ryan M , Stewart Adam J 
Published: October 2024

ABSTRACT
Several sources of repeating coherent bursts of radio emission with periods of many minutes have now been reported in the literature. These ‘ultralong period’ (ULP) sources have no clear multiwavelength counterparts and challenge canonical pulsar emission models, leading to debate regarding their nature. In this work, we report the discovery of a bright, highly polarized burst of radio emission at low Galactic latitude as part of a wide-field survey for transient and variable radio sources. ASKAP J175534.9$-$252749.1 does not appear to repeat, with only a single intense two-minute $\sim$200-mJy burst detected from 60 h of observations. The burst morphology and polarization properties are comparable to those of classical pulsars but the duration is more than one hundred times longer, analogous to ULPs. Combined with the existing ULP population, this suggests that these sources have a strong Galactic latitude dependence and hints at an unexplored population of transient and variable radio sources in the thin disc of the Milky Way. The resemblance of this burst with both ULPs and pulsars calls for a unified coherent emission model for objects with spin periods from milliseconds to tens of minutes. However, whether or not these are all neutron stars or have the same underlying power source remains open for debate.
Effectiveness and Safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide in Late-Presenting People With HIV-1 Infection
Authors: Yang Xiaoyan , Xie Xiaoxin , Fu Yanhua , Gan Lin , Ma Shujing , Long Hai 
Published: October 2024

Abstract

Background
The efficacy and safety of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) have been demonstrated in treatment-naive clinical trials. However, real-world evidence for this regimen in late-presenting patients with HIV-1 (PWH) is lacking. We investigated the virologic and safety outcomes of BIC/FTC/TAF in late-presenting PWH.

Methods
This retrospective cohort analysis consisted of late-presenting PWH who initiated an antiretroviral regimen of BIC/FTC/TAF between June 2021 and June 2023. Treatment effectiveness, defined as HIV-1 RNA &lt;50 copies/mL, was analyzed. Changes in immunologic, metabolic, liver, and renal parameters were evaluated. Late-presenting PWH were defined as surviving PWH with CD4 &lt;200 cells/μL or surviving patients who met the criteria for AIDS-defining conditions with a CD4 ranging from 200 to 499 cells/μL.

Results
A total of 130 participants were included in the study. At week 48, 93.8% (122/130) of the patients achieved HIV-1 RNA levels &lt;50 copies/mL. CD4 increased by 150.0 cells/μL, and CD4/CD8 increased by 0.16 (P &lt; .001). Sixteen (12.3%) participants experienced adverse events, and 6 (4.6%) experienced drug-related adverse events. None of the participants discontinued treatment due to either a lack of effectiveness or adverse events.

Conclusions
BIC/FTC/TAF demonstrated robust virologic suppression and tolerability in patients presenting late in the course of HIV infection.
TRANSPARENT TESTA 16 collaborates with the MYB-bHLH-WD40 transcriptional complex to produce brown fiber cotton
Authors: Li Yuanxue , Yao Tian , Fu Chao , Wang Nian , Xu Zhiyong , Yang Ningyu , Zhang Xianlong , Wen Tianwang , Lin Zhongxu 
Published: October 2024

Abstract
Naturally colored cotton (NCC; Gossypium spp.) does not require additional chemical dyeing and is an environmentally friendly textile material with great research potential and applications. Our previous study using linkage and association mapping identified TRANSPARENT TESTA 2 (Gh_TT2) as acting on the proanthocyanin synthesis pathway. However, limited information is available about the genetic regulatory network of NCC. Here, we verified the effectiveness of Gh_TT2 and the roles of Gh_TT2 and red foliated mutant gene (Re) in pigment formation and deposition of brown fiber cotton (BFC). Variations in Gh_TT2 derived from interspecific hybridization between Gossypium barbadense acc. Pima 90-53 and Gossypium hirsutum acc. Handan208 resulted in gene expression differences, thereby causing phenotypic variation. Additionally, the MYB-bHLH-WD complex was found to be negatively modulated by TRANSPARENT TESTA 16/ARABIDOPSIS BSISTER (TT16/ABS). RNA-seq suggested that differential expression of homologous genes of key enzymes in the proanthocyanin synthesis pathway strongly contributes to the color rendering of natural dark brown and light brown cotton. Our study proposes a regulatory model in BFC, which will provide theoretical guidance for the genetic improvement of NCC.
Role of Embolic Protection in Percutaneous Coronary Intervention Without Saphenous Venous Graft Lesions in ST-Segment–Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis
Authors: Maliha Maisha , Satish Vikyath , Chi Kuan Yu , Zeas Diego Barzallo , Kharawala Amrin , Shama Nishat , Abittan Nathaniel , Nandy Sneha , Osabutey Anita , Madan Nidhi , Singh Prabhjot , Gashi Eleonora 
Published: October 2024

Introduction:
Embolic protection devices (EPDs) are catheter-based devices that can be used to capture atherosclerotic remnants released during percutaneous coronary intervention (PCI). We aim to study the efficacy and safety of EPDs in PCIs without saphenous vein grafts (SVGs) in ST-segment–elevation myocardial infarction (MI).

Methods:
Three electronic databases of MEDLINE, Web of Science, and Embase were searched from inception to April 10, 2024, to identify relevant randomized controlled trials that compared outcomes of patients subjected to EPD during PCI with a control group where EPDs were not utilized. The primary outcome was 30-day all-cause mortality. Secondary outcomes were major adverse cardiovascular and cerebrovascular events at 30 days, post-PCI thrombolysis in MI grade 3 flow attainment, ST-segment resolution at 90 minutes post-procedure, and postprocedure angiographically detectable signs of distal embolization. The effect estimates of outcomes were assessed using risk ratio (RR) with a 95% confidence interval (CI). Random-effects meta-analysis was conducted using the restricted maximum likelihood method, given that the interstudy variance was inevitable.

Results:
We included 3 randomized controlled trials enrolling 741 patients (age, 61.6 ± 12.15 years; 22% females) undergoing PCI without SVG lesions. As opposed to the control group, the use of EPD did not yield a significant effect on all-cause mortality [RR, 0.76 (95% CI, 0.31–1.86); I2 = 0%], major adverse cardiovascular and cerebrovascular events [RR, 0.66 (95% CI, 0.34–1.27); I2 = 0%], post-PCI thrombolysis in MI 3 flow [RR, 1.18 (95% CI, 0.86–1.62); I2 = 77%], and ST-segment resolution at 90 minutes post-procedure [RR, 1.05 (95% CI, 0.90–1.22); I2 = 0%]. However, EPD significantly decreased angiographically detectable signs of distal embolization [RR, 0.60 (95% CI, 0.36–0.99); I2 = 0%].

Conclusions:
EPD significantly reduced angiographically detectable signs of distal embolization in PCI without SVG lesions in ST-segment–elevation MI though there were no clinical signs of improved flow or mortality. Further trials are necessary to thoroughly evaluate the potential benefits and requirements of EPD usage in such procedures.
Economics of risk stratification for skin cancer screening in solid organ transplant recipients
Authors: McAuliffe Dominic L. , Griffith Cynthia F. , Korzeniowski Pamela 
Published: October 2024

Background:
Solid organ transplant recipients (SOTRs) have different risks of developing skin cancer depending on patient characteristics. However, there is currently no widely used tool to stratify skin cancer risk in these patients. The Skin and Ultraviolet Neoplasia Transplant Risk Assessment Calculator (SUNTRAC) is an attempt to stratify skin cancer risk in SOTRs and guide screening recommendations for those patients.

Materials and methods:
It was assumed that the 2022 solid organ transplant population in the United States would follow the same distribution of skin cancer risk as the population in the study that led to the development of the SUNTRAC. The total number of skin cancer screening visits and the total cost of those visits over 10 years were determined utilizing the screening recommendations in the SUNTRAC.

Results:
If all SOTRs received yearly skin cancer screens, 428,870 office visits would be conducted over 10 years for a total cost of $94,780,270. If the SUNTRAC were utilized, 336,666 office visits would be conducted for a 10-year cost of $74,403,186.

Conclusions:
Utilizing the SUNTRAC to guide skin cancer screening recommendations in SOTRs has the potential to minimize over-screening and lower the total cost of skin cancer screening visits for SOTRs. Initial studies into the applicability of the SUNTRAC have found similar risk distribution in different populations of SOTRs. Utilizing this model to guide skin cancer screening recommendations will better allocate resources to the highest risk patients while also avoiding unnecessary health care costs.
Plan of Care Visits
Authors: Masiano Steven P. , Rose Susannah , Wolfe Judith , Albert Nancy M. , Milinovich Alex , Jurecko Leslie , Ridgeway Beri , Kattan Michael W. , Misra-Hebert Anita D. 
Published: October 2024

Background:
Plan of Care of Visits (POCV), including the patient, nurse, and hospital provider were implemented across an integrated health system to improve provider-patient communication during hospitalization and patient outcomes.

Objectives:
To assess POCV adoption after implementation, patient characteristics assosites were classified as teachsites were classified as teachsites were classified as teachsites were classified as ciated with POCV completion, and association of POCV with 30-day readmissions.

Methods:
This retrospective cohort study utilized electronic medical record (EMR) data of 237,430 adult patients discharged to home from 11 hospitals from January 2020 to December 2022. POCV completion was a discrete EMR variable. POCV adoption was estimated monthly by hospital as proportion of patients with at least 1 POCV during hospitalization, with variation among hospitals measured using the Variance Partition Coefficient (VPC). Multivariable logistic regressions assessed factors associated with POCV completion and POCV association with 30-day readmission.

Results:
POCV adoption increased from 69% to 94% (2020–2022) and varied by 50% across hospitals (VPC 0.50, 95% CI: 0.29–0.70). Odds of a discharge-day POCV were lower among older patients (≥65 vs. 18–34 y, OR 0.81, CI: 0.79–0.83), and higher among female (OR 1.06; CI: 1.04–1.07), Asian (vs. White, OR 1.13; CI: 1.06–1.21), Hispanic (OR 1.09; CI: 1.05–1.13), and surgical patients (vs. medical, OR 1.33; CI: 1.30–1.35). Patients completing discharge-day POCV had lower 30-day readmission odds (2022 OR 0.76, CI: 0.73–0.79). Patients with POCV on ≥75% of hospital days had similar readmission odds trends.

Conclusions:
POCV implementation was successful, and POCV completion was associated with fewer 30-day readmissions. Future work should focus on increasing POCV adoption while reducing hospital variation.
The current state of tolerance induction in vascularized composite allotransplantation
Authors: Blades Caitlin M. , Huang Christene A. , Mathes David W. 
Published: October 2024

Purpose of review
Significant advancements have been made in the field of vascularized composite allotransplantation (VCA); however, like solid organ transplantation, bypassing the recipient's immune response remains a significant obstacle to long-term allograft survival. Therefore, strategies to overcome acute and chronic rejection and minimize immunosuppressive therapy are crucial for the future of VCA. This review highlights recent attempts to induce tolerance in VCA and discusses key findings through a clinical lens.

Recent findings
Promising VCA tolerance protocols are being investigated, with five recent studies illustrating various successes. These preclinical approaches demonstrate a correlation between the presence of donor-derived T cells and VCA tolerance, the importance of using clinically available reagents within preclinical protocols, and the ability to induce sustained tolerance through nonmyeloablative methods. Furthermore, environmental factors, such as NB-UVB light are being investigated for their immunomodulation properties and may influence VCA graft rejection.

Summary
To widen the scope of VCA, minimization of immunosuppression is needed. Overall, tolerance induction protocols should have a low-toxicity level, minimally invasive induction therapies, and utilize short-term immunosuppressive medications. By examining the milestones of recent studies, researchers can gain new technical approaches to immune modulation and make data-driven amendments to tolerance protocols in preparation for clinical translation.
Mechanical thrombectomy by stent retriever for the treatment of arterial ischemic stroke in a pediatric patient with acute lymphoblastic leukemia: a case report
Authors: Khameneh Bagheri Arash , Khalili Mitra , Alavi Samin , Khaffafpour Zahra , Aghapour Mehdi , Zamani Alireza , Mirmoghaddam Paniz 
Published: October 2024

Introduction:
Arterial ischemic stroke (AIS) caused by occlusion of large vessels in childhood is a devastating rare condition that can contribute to long-term disabilities. Childhood leukemia is identified as a recognized risk factor for ischemic strokes. Mechanical thrombectomy is the standard of care for large vessel occlusions in adults. However, there are still no definite recommendations regarding the application and outcomes of endovascular thrombectomy and the devices used for pediatric patients with arterial ischemic stroke.

Case presentation:
The authors report a 13-year-old female with acute lymphoblastic leukemia who developed AIS due to thrombosis in the left internal carotid and proximal middle cerebral artery in the induction phase of treatment. The patient underwent successful mechanical thrombectomy via Solumbra by using “Embolus Retriever with Interlinked Cages (ERIC)” stent retriever and Sofia plus catheter, which resulted in successful recanalization of ICA and MCA.

Discussion:
Selected pediatric patients with AIS due to large vessel occlusions can benefit from mechanical thrombectomy. Although the recently published literature demonstrated the efficacy and safety of MT in children, strong guideline recommendations are still absent. At present, the last AHA/ASA guidelines for early management of AIS recommends intravenous thrombolysis and endovascular therapy in adults, whereas controversy still exists in children. An urgent approach within the defined therapeutic time frame and a multidisciplinary team specialized in pediatric stroke with professionally trained interventional neuroradiologist is essential for achieving optimal results.

Conclusion:
Mechanical thrombectomy provides promising results with high rates of arterial recanalization and favorable outcomes in pediatric patients with AIS.
Nurses’ Perception of Firearm Safety
Authors: Cypress Brigitte S. , Caboral-Stevens Meriam , Rosario-Sim Maria G. , Sagar Priscilla L. 
Published: October 2024

Abstract

Background
Firearm or gun violence has become a significant and ongoing public health crisis in the United States. There is little evidence of the current practices of nurses in assessing, screening, and counseling patients and families on firearm ownership and safety.

Objectives
The purpose of this exploratory qualitative study was to explore the attitudes, perceptions, and current practices in assessing, screening, and counseling gun ownership and safety among registered nurses, with a secondary aim of identifying the facilitators and barriers to implementing the practice.

Method
An exploratory qualitative research study design was used. We recruited focus group participants via e-mail, social media blasts, referrals, and personal contact requests. Participants were interviewed using structured focus group questions via Zoom. Five focus groups included 32 registered and advanced practice nurses. The audio-recorded and transcribed data were analyzed using Braun and Clarke’s approach to thematic analysis.

Results
We identified four key themes. First, there was a significant need to educate and train nurses in the assessment, screening, and counseling about firearm safety. Second, there was a need to extend this education to patients, families, and the community. Third, there was a need to advocate for the creation and implementation of policies. Fourth, there was a need to implement mental health assessment as a standard practice before owning a gun, which emerged as a potential solution. Additionally, we found a need to address barriers to assessment and counseling on gun use. The creation of state laws and organizational policies, along with the provision of current data, emerged as other facilitators for assessment, screening, and counseling among nurses about firearms use and safety.

Discussion
Ours is one of the first studies to explore attitudes and perceptions about gun ownership and current practices in gun safety assessment, screening, and counseling among registered nurses. The findings lay some foundation for a focused, multifaceted approach and interventions to address gun violence and safety concerns.