bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility
Authors: Wang Yujia , Wu Zenghui , Luo Hongyu , Peng Junzheng , Raelson John , Ehret Georg B. , Munroe Patricia B. , Stoyanova Ekatherina , Qin Zhao , Cloutier Guy , Bradley W. Edward , Wu Tao , Shen Jian-Zhong , Hu Shenjiang , Wu Jiangping 
Published: December 2016

AbstractSeveral erythropoietin-producing hepatocellular receptor B family (EPHB) and their ligands, ephrinBs (EFNBs), are involved in blood pressure regulation in animal models. We selected 528 single nucleotide polymorphisms (SNPs) within the genes of EPHB6, EFNB2, EFNB3 and GRIP1 in the EPH/EFN signalling system to query the International Blood Pressure Consortium dataset. A SNP within the glutamate receptor interacting protein 1 (GRIP1) gene presented a p-value of 0.000389, approaching the critical p-value of 0.000302, for association with diastolic blood pressure of 60,396 individuals. According to echocardiography, we found that Efnb3 gene knockout mice showed enhanced constriction in the carotid arteries. In vitro studies revealed that in mouse vascular smooth muscle cells, siRNA knockdown of GRIP1, which is in the EFNB3 reverse signalling pathway, resulted in increased contractility of these cells. These data suggest that molecules in the EPHB/EFNB signalling pathways, specifically EFNB3 and GRIP1, are involved blood pressure regulation.
Nano-hemostats and a Pilot Study of Their Use in a Large Animal Model of Major Vessel Hemorrhage in Endoscopic Skull Base Surgery
Authors: Murphy Jae , Vreugde Sarah , Psaltis Alkis , Wormald P. , Jukes Alistair 
Published: December 2016

AbstractNano-hemostats are synthetic amino acid chains that self-assemble into a scaffold under certain conditions. These have been shown to be effective in stopping bleeding in small animal models of hemorrhage. Proposed mechanisms for their effect are that they form a mesh analogous to the fibrin plug in native hemostasis and that they may potentiate both platelet activation and the coagulation cascade. These may potentially become valuable adjuncts to endoscopic skull base surgery where there is the potential for both major vessel injury and smaller perforator injury to eloquent areas where bipolar cautery may not be suitable. We present a summary of the clinical studies to date and a small pilot study of nano-hemostat in an endoscopic sheep model of major vessel hemorrhage to determine its efficacy in stopping bleeding in this potentially catastrophic complication.
Invariant superoscillatory electromagnetic fields in 3D-space
Authors: Makris K G , Papazoglou D G , Tzortzakis S 
Published: December 2016

Abstract
We derive exact solutions of Maxwell’s equations based on superoscillatory superpositions of vectorial Bessel beams. These novel beams are diffraction-free and can support subwavelength features in their transverse electromagnetic fields, without the presence of any evanescent waves. These features can be propagated into the far field. Approximate solutions in closed form are also derived based on asymptotic expansions of Bessel functions for simple prescribed subwavelength patterns. The superoscillatory characteristics of both electric, magnetic field components (transverse and longitudinal), and the Poynting vector, as well as, the effect of nonparaxiality are systematically investigated.
Prevalence of HPV infection in racial–ethnic subgroups of head and neck cancer patients
Authors: Ragin Camille , Liu Jeffrey C. , Jones Gieira , Shoyele Olubunmi , Sowunmi Bukola , Kennett Rachel , Gibbs Denise , Blackman Elizabeth , Esan Michael , Brandwein Margaret S. , Devarajan Karthik , Bussu Francesco , Chernock Rebecca , Chien Chih-Yen , Cohen Marc A. , El-Mofty Samir , Suzuki Mikio , D’Souza Gypsyamber , Funchain Pauline , Eng Charis , Gollin Susanne M. , Hong Angela , Jung Yuh-S , Krüger Maximilian , Lewis James , Morbini Patrizia , Landolfo Santo , Rittà Massimo , Straetmans Jos , Szarka Krisztina , Tachezy Ruth , Worden Francis P. , Nelson Deborah , Gathere Samuel , Taioli Emanuela 
Published: December 2016

AbstractThe landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P &lt; 0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P &lt; 0.0001). There was no statistically significant difference in HPV16,18 prevalence in non-oropharyngeal cancer by race (P = 0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6%, respectively) [P &lt; 0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
Explaining the Increase in Female Mayors: Gender-Segregated Employment and Pathways to Local Political Leadership
Authors: TSUJI Yuki 
Published: December 2016

AbstractInternationally, Japan ranks very low in the number of women in political leadership roles. Since the 1990s, the number of women serving in the national and local legislative assemblies has increased, and since 2000, the number of women serving as governors or mayors has also gradually increased. In particular, the number of female mayors has grown significantly in recent years. This article attempts to clarify the reasons for the increase in female mayors by examining the careers of women elected since the early 21st century and four case studies that illuminate various pathways to power for female mayors. We suggest that Japan’s gender-segregated employment practices have inadvertently created a new pathway to local power for women, from housewife to civil society leaders, and ultimately to local politician. We consider issues such as supply and demand, and other background environmental factors that affect women’s candidacy within mayoral elections. Furthermore, through four case studies, we show that three of four women capitalized on their ‘outsider’ profiles in their mayoral elections through critiques of the previous mayors’ management. Moreover, all of the women made campaign promises on the expansion of care services and the realization of local fiscal responsibility.
Transcriptional signatures of connectomic subregions of the human striatum
Authors: Parkes Linden , Fulcher Ben , Yücel Murat , Fornito Alex 
Published: December 2016

AbstractFunctionally distinct regions of the brain are thought to possess a characteristic connectional fingerprint – a profile of incoming and outgoing connections that defines the function of that area. This observation has motivated efforts to subdivide cortical and subcortical areas using their patterns of connectivity. However, it remains unclear whether these connectomically-defined subregions of the brain can be distinguished at the molecular level. Here, we combine high-resolution diffusion-weighted magnetic resonance imaging with comprehensive transcriptomic data to show that connectomically-defined subregions of the striatum carry distinct transcriptional signatures. Using data-driven clustering of diffusion tractography, seeded from the striatum, in 100 healthy individuals, we identify a tripartite organization of the caudate and putamen that comprises ventral, dorsal, and caudal subregions. We then use microarray data of gene expression levels in 19 343 genes, taken from 98 tissue samples distributed throughout the striatum, to accurately discriminate the three connectomically-defined subregions with 80-90% classification accuracy using linear support vector machines. This classification accuracy was robust at the group and individual level. Genes contributing strongly to the classification were enriched for gene ontology categories including dopamine signaling, glutamate secretion, response to amphetamine, and metabolic pathways, and were implicated in risk for disorders such as schizophrenia, autism, and Parkinson’s disease. Our findings highlight a close link between regional variations in transcriptional activity and interregional connectivity in the brain, and suggest that there may be a strong genomic signature of connectomically-defined subregions of the brain.
RL mechanisms of short-term plasticity of auditory cortex
Authors: Krugliakova Elena , Gorin Alexey , Shestakova Anna , Fedele Tommaso , Klucharev Vasily 
Published: December 2016

AbstractThe decision-making process is exposed to modulatory factors, and, according to the expected value (EV) concept the two most influential factors are magnitude of prospective behavioural outcome and probability of receiving this outcome. The discrepancy between received and predicted outcomes is reflected by the reward prediction error (RPE), which is believed to play a crucial role in learning in dynamic environment. Feedback related negativity (FRN), a frontocentral negative component registered in EEG during feedback presentation, has been suggested as a neural signature of RPE. In modern neurobiological models of decision-making the primary sensory input is assumed to be constant over the time and independent of the evaluation of the option associated to it. In this study we investigated whether the electrophysiological changes in auditory cues perception is modulated by the strengths of reinforcement signal, represented in the EEG as FRN.We quantified the changes in sensory processing through a classical passive oddball paradigm before and after performance a neuroeconomic monetary incentive delay (MID) task. Outcome magnitude and probability were encoded in the physical characteristics of auditory incentive cues. We evaluated the association between individual biomarkers of reinforcement signal (FRN) and the degree of perceptual learning, reflected by changes in auditory ERP components (mismatch negativity and P3a). We observed a significant correlation of MMN and valence - dFRN, reflecting differential processing of gains and omission of gains. Changes in P3a were correlated to probability - dFRN, including information on salience of the outcome, in addition to its valence.MID task performance evokes plastic changes associated with more fine-grained discrimination of auditory anticipatory cues and enhanced involuntary attention switch towards these cues. Observed signatures of neuro-plasticity of the auditory cortex may play an important role in learning and decision-making processes through facilitation of perceptual discrimination of valuable external stimuli. Thus, the sensory processing of options and the evaluation of options are not independent as implicitly assumed by the modern neuroeconomics models of decision-making.
A systematic literature review on green manufacturing concepts in cement industries
Authors: Shrivastava Sanjeev , R.L. Shrivastava 
Published: December 2016

Purpose
The purpose of this paper is to survey the technical performance of the cement industry including those related to procedures; groundwork of raw materials, fuels and semi-finished products for processing; accessibility of machinery, plant and equipment for various operations; arrangement and process control management.

Design/methodology/approach
A broad range of survey and research was reviewed, and all revealed the methods to recognize the key influences for development of green technology. The study explores the present scenario of green manufacturing (GM) strategies of Indian cement companies and provides the industrial ecology, ways of reducing energy consumption, environmental impact data collection, design and control of manufacturing systems and integration of product and manufacturing system. It also reveals the problems in decision-making systems owing to the impact of the green product design. Here, in this paper, all information is obtained by the medium of internet, journals, articles, and magazines.

Findings
This paper describes a problem of global warming, gas, water and other wastages emissions at the time of cement manufacturing and put forward a path that enables decision makers to assess the perception of GM in their organization and in prioritizing GM efforts.

Originality/value
This perspective survey is to provide an integrative outlook of performance methods for GM practices in the Indian cement industries. It gives important information, which expectantly will help in cement industry to adopt GM practices. This paper fills the gap in the literature on identification, establishment, and validation of performance measures of GM for Indian cement industries.
Supply chain management and quality management integration
Authors: Fernandes Ana Cristina , Sampaio Paulo , Sameiro Maria , Truong Huy Quang 
Published: December 2016

Purpose
The purpose of this paper is to develop a theoretical basis for integration of quality management (QM) and supply chain management (SCM). For that purpose, some common practices of both approaches are identified as having impact on the four balanced scorecard perspectives.

Design/methodology/approach
The main concepts of SCM and QM were reviewed from the literature in order to develop key practices that are common to both approaches.

Findings
The findings suggest that the synergies of QM and SCM can promote the integration of the approaches which will promote a set of significant organizational benefits.

Originality/value
This study focuses on the integration of QM and SCM through their common practices. This issue has not been broadly explored and for that reason this paper contributes to the understanding of the critical factors for an effective integration of supply chain QM.
The X-bar control chart with restriction of the capability indices
Authors: Oprime Pedro Carlos , Mendes Glauco Henrique de Sousa 
Published: December 2016

Purpose
The purpose of this paper is to find the configuration of the number (m) and size (n) of the sample in Phase I that would make it possible to detect the out-of-control (OOC) state of the process with the smallest number of samples and ensure a capability index (Cpk) that would meet the customer’s requirements.

Design/methodology/approach
The suggested approach addresses this problem using simulation techniques and design of experiments (DOE). The simulation techniques made it possible to reproduce the normal operating conditions of the process. The DOE was used to construct a predictive model for control chart performance and thus to determine combinations of m and n in Phase I that would meet the capability objectives of the process. A numerical example and a simulation study were conducted to illustrate the proposed method.

Findings
Using simulation techniques and DOE, the authors can find the number (m) and size (n) of the sample in Phase I that would make it possible to detect the OOC state of the process with the smallest number of samples and ensure a Cpk that would meet the customer’s requirements.

Originality/value
In the real situations of many companies, choosing the numbers and sizes of samples (m and n) in Phases I and II is a crucial decision in relation to implementing a control chart. The paper shows that the simulation method and use of linear regression are effective alternatives because they are better known and more easily applied in industrial settings. Therefore, the need for alternatives to the X control chart comes into play.
Application of the mixed Weibull distribution in machine reliability analysis for a cell formation problem
Authors: Ghavijorbozeh Reza , Zeinal Hamadani Ali 
Published: December 2016

Purpose
The purpose of this paper is to understand the consequence of the use of mixed Weibull distribution in the cell formation problem. In reliability theory, a mixed distribution is used for more than one hazard cause, and the Weibull distribution can be used for ascendant, monotonous and descendant failure rate. Here, the authors mixed these two theme and use it in a common problem in group technology.

Design/methodology/approach
In this paper, the authors made a non-polynomial-hard mathematical model based on past research and solved it with an exact algorithm. The algorithm is coded and solved in GAMS to illustrate the model, and the authors use simulation. A common numerical example is solved with the model, and the results are compared.

Findings
Reliability analysis model based on the mixed Weibull distribution approach will give options to a user to select the suitable failure rate and modes for a specific situation. If the user uses the exponential or Weibull distribution instead of the mixed Weibull distribution, the calculated cost and reliability are wrong; therefore, it leads to user making wrong decisions.

Originality/value
The model the authors use is the one used in past research, but in the past, researchers did not use the mixed distribution for explaining failure time. Therefore, the model can be considered as a new and more complete model.
Stochastic modelling of a wind electric generating power plant
Authors: Goyal Nupur , Ram Mangey 
Published: December 2016

PurposeThe purpose of this paper is to analyse the performance of a wind electric generating power plant through the study of reliability measures. The enhancement of the performance of the wind power plant using various approaches is also an objective of this paper.Design/methodology/approachThis paper describes two models of a wind electric generating power plant using the Markov process and supplementary variable technique and solved with the help of Laplace transformation. The first model has been analyzed without fault coverage and Gumbel-Hougaard family of copula, while the second model of the wind power plant employs fault coverage and Gumbel-Hougaard family of copula which are used to enhance the performance. The proposed methodology is then illustrated in detail considering numerical examples.FindingsNumerous reliability characteristics such as availability, reliability and mean time to failure to examine the performance of the wind power plant have been investigated. Through the comparative study of both the models, the authors concluded that the plant can generate electricity over long periods of time by covering more and more detected faults, which is made possible with two types of repair facility.Originality/valueIn this work, the authors have developed a mathematical model based on a wind electric generating power plant. This work incorporates not only the component failures that stop or degrade the working of the plant but also deals with the catastrophic and repair strategy of the plant.
“Data and dissertations”-ETD 2016@ Université Lille Nord de France
Authors: Ghosh Maitrayee 
Published: December 2016

Purpose
Electronic theses and dissertation (ETD) symposium is one of the major international activities of Networked Digital Library of Theses and Dissertations (NDLTD), and its objectives provide a platform for the exchange of knowledge and skills relevant to ETD students, professors and information professionals. This symposium offers an opportunity to put forward innovative plans, debate on ideas and promote closer cooperation internationally. This report is a summary of selected events held during ETD international symposium 2016 on the theme “Data and Dissertations”, with a focus on the handling of research data.

Design/methodology/approach
It is a concise review of selected presentations during 19th electronic theses and dissertation annual symposium in University of Lille, France.

Findings
ETD 2016 meeting held in Lille was attended by nearly 100 attendees from 28 countries. This report includes a summary of selected presentations on research data, open-access and embargo policies, augmented ETDs and French system for ETDs. It is useful to managers of organizations, teachers and educators, librarians, open-access protagonists and members of information provider communities. The personal interaction with the participants from different countries enriched the author’s ideas about the ETD development.

Originality/value
The author, who was also a speaker, provides an overview of the selected presentations on the initiatives, namely, research data development, copyright laws, augmented digital theses, plagiarism, etc. The important events such as sight-seeing tours to a national museum, informal get-together are covered which may be useful to the audience who are not able to attend but interested to know about ETD 2016.
The Mental Health Parity and Addiction Equity Act Evaluation Study: Impact on Mental Health Financial Requirements among Commercial “Carve‐In” Plans
Authors: Friedman Sarah A. , Thalmayer Amber G. , Azocar Francisca , Xu Haiyong , Harwood Jessica M. , Ong Michael K. , Johnson Laura Lambert , Ettner Susan L. 
Published: December 2016

ObjectiveDid mental health cost‐sharing decrease following implementation of the Mental Health Parity and Addiction Equity Act (MHPAEA)?Data SourceSpecialty mental health copayments, coinsurance, and deductibles, 2008–2013, were obtained from benefits databases for “carve‐in” plans from a national commercial managed behavioral health organization.Study DesignBivariate and regression‐adjusted analyses compare the probability of use and (conditional) level of cost‐sharing pre‐ and postparity. An interaction term is added to compare differential levels of pre‐ and postparity cost‐sharing changes for plans that were and were not already at parity pre‐MHPAEA.FindingsControlling for employer/plan characteristics, MHPAEA is associated with higher intermediate care copayments ($15.9) but lower outpatient ($2.6) copayments among in‐network‐only plans. Among plans with in‐ and out‐of‐network benefits, MHPAEA is associated with lower inpatient ($23.2) and outpatient ($2.5) copayments, but increases in inpatient and intermediate in‐network and out‐of‐network coinsurance (about 1 percentage point). Among the few plans not at parity pre‐MHPAEA, changes in use and level of cost‐sharing associated with MHPAEA were more dramatic.ConclusionMixed evidence that MHPAEA led to more generous mental health benefits may stem from the finding that many plans were already at parity pre‐MHPAEA. Future policy focus in mental health may shift to slowing growth in cost‐sharing for all health services.