bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of Gran Teatro Nacional in Lima—A world class opera house in South America
Authors: Nepomuceno José A. , Gaspar Julio 
Published: May 2016

The design of Gran Teatro Nacional in Lima, Peru, started in 2009 as very special task. Peru needed a venue with world-class standards to host local and international events of opera, concerts, and ballet. The theater has a built area of about 26 000 m2 with 1500 seats capacity. It has a fully equipped fly tower with motorized winches, an 11 m tall acoustical shell, 4 double deck stage lifts, 2 orchestra lifts, and a pit for 100 players. The equipment complies with the most restrictive European standards. The acoustics oriented the design, from room shaping to its volume, from materiality to seats selection. The acoustical consultants assumed modified horseshoe plan to improved intimacy and three tier levels. The hall has two reverberation chambers and several acoustical banners to provide variability in the acoustical response of the hall. Computer modeling and physical model supported the design. Since the Gala Opening in 2012 the theater has been getting remarkable reviews from conductors, international orchestras, and artists in general. The theater complied with the mission of bringing a world class performing art center to Peru. The paper provides the history of the project, architectural, and construction details and acoustical data.
Draft Genome Sequences of Seven Thermophilic Spore-Forming Bacteria Isolated from Foods That Produce Highly Heat-Resistant Spores, Comprising
Geobacillus
spp., Caldibacillus debilis, and Anoxybacillus flavithermus
Authors: Berendsen Erwin M. , Wells-Bennik Marjon H. J. , Krawczyk Antonina O. , de Jong Anne , van Heel Auke , Holsappel Siger , Eijlander Robyn T. , Kuipers Oscar P. 
Published: May 2016

ABSTRACT

Here, we report the draft genomes of five strains of
Geobacillus spp.
, one
Caldibacillus debilis
strain, and one draft genome of
Anoxybacillus flavithermus
, all thermophilic spore-forming Gram-positive bacteria.
Complete Genome Sequences of Three African Foot-and-Mouth Disease Viruses from Clinical Samples Isolated in 2009 and 2010
Authors: Van Borm Steven , Rosseel Toon , Haegeman Andy , Fana Mpolokang Elliot , Seoke Latoa , Hyera Joseph , Matlho George , Vandenbussche Frank , De Clercq Kris 
Published: May 2016

ABSTRACT
The complete genome sequences of three foot-and-mouth disease viruses (one virus of each serotype SAT1, SAT2 and O) were directly sequenced from RNA extracted from clinical bovine samples, demonstrating the feasibility of full-genome sequencing from strong positive samples taken from symptomatic animals.
Simple Interventions Improve the Quality of a Missed Lab Appointment Process
Authors: Mookadam Martina , Grover Michael , Pullins Chris , Winscott Mary , Pierce Susan 
Published: May 2016

Simple interventions resolve the problem of missed lab appointments.It is essential that patients complete ordered laboratory studies. This maintains clinical quality and, potentially, keeps patients safe from harm. In our academic family medicine practice, baseline data demonstrated patients completed 94.7% of labs as ordered (26850/28348 patients per year) while 1498 (5.3%) did not. Our baseline patient reminder process, a mail or portal based generic letter, resulted in only 449 (30%) of patients ultimately completing them (1049 [70%] did not). Our baseline system was 96.3 % reliable. This process did not allow for provider review or input, and was not personalized for patients.We designed a quality improvement project involving three PDSA (Plan, Do, Study, and Act) cycles of about two months each. Desk staff created weekly reports of unresolved lab orders. A message in the electronic medical record (EMR) solicited provider input. Providers could elect to cancel studies (if already completed, reordered, or no longer clinically indicated) or have the patient receive a personalized reminder, including provider name and associated diagnoses. This reminder was sent by patient portal secure messaging (if an account existed) or with a mailed letter. These interventions resulted in 98.8 % process reliability. The frequency of unresolved lab orders decreased from 70% at baseline to 25%.In the second PDSA cycle, we contacted patients by the portal only if there was evidence of an active account. Otherwise, they were contacted by telephone. Patients without a portal account continued to receive a letter by mail. These modified processes resulted in an overall reliability rate of 99.2%. The frequency of unresolved lab orders decreased to 17%.A final PDSA cycle utilized only telephone contact with patients with unresolved lab orders. Schedulers offered patients a choice of appointment dates if they spoke personally. Otherwise, they were left messages with a future lab appointment date two weeks later.Overall process reliability now increased to 100%. The frequency of unresolved lab orders decreased to 0%.Our interventions resulted in increased system reliability.Provider input was not perceived as burdensome. Desk staff work effort was not increased.Telephone patient contact resulted in more frequent lab order completion than other methods.
Introducing routine HIV screening for patients on an internal medicine residency inpatient service: a quality improvement project
Authors: Padrnos Leslie J , Barr Patrick J , Klassen Christine L , Fields Heather E , Azadeh Natalya , Mendoza Neil , Saadiq Rayya A , Pauwels Emanuel M , King Christopher S , Chung Andrew A , Sakata Kenneth K , Blair Janis E 
Published: May 2016

The US Centers for Disease Control and Prevention (CDC) recommend human immunodeficiency virus (HIV) screening for all persons aged 13 to 64 years who present to a health care provider. We sought to improve adherence to the CDC guidelines on the Internal Medicine Resident Hospital Service. We surveyed residents about the CDC guidelines, sent email reminders, provided education, and engaged them in friendly competition. Credit for guideline adherence was awarded if an offer of HIV screening was documented at admission, if a screening test was performed, or if a notation in the resident sign out sheet indicated why screening was not performed.We examined HIV screening of a postintervention group of patients admitted between August 8, 2012, and June 30, 2013, and compared them to a preintervention group admitted between August 1, 2011, and June 30, 2012. Postintervention offers of HIV screening increased significantly (7.9% [44/559] vs 55.5% [300/541]; P<.001), as did documentation of residents' contemplation of screening (8.9% [50/559] vs 67.5% [365/541]; P<.001). A significantly higher proportion of HIV screening tests was ordered postintervention (7.7% [43/559] vs 44.4% [240/541]; P<.001). Monthly HIV screening documentation ranged from 0% (0/53) to 17% (9/53) preintervention, whereas it ranged from 30.6% (11/36) to 100% (62/62) postintervention.HIV screening adherence can be improved through resident education, friendly competition, and system reminders. Barriers to achieving sustained adherence to the CDC guidelines include a heterogeneous patient population and provider discomfort with the subject.
Exploring a new ultrasound score as a clinical predictive tool in patients with rheumatoid arthritis starting abatacept: results from the APPRAISE study
Authors: D'Agostino Maria-Antonietta , Boers Maarten , Wakefield Richard J , Berner Hammer Hilde , Vittecoq Olivier , Filippou Georgios , Balint Peter , Möller Ingrid , Iagnocco Annamaria , Naredo Esperanza , Østergaard Mikkel , Gaillez Corine , Le Bars Manuela 
Published: May 2016

ObjectivesTo explore whether changes in a composite (power Doppler/greyscale ultrasound (PDUS)) synovitis score, developed by the OMERACT-EULAR-Ultrasound Task Force, predict disease activity outcomes in rheumatoid arthritis (RA).MethodsPatients with RA who were methotrexate inadequate responders starting abatacept were evaluated. Individual joint PDUS scores were combined in the Global OMERACT-EULAR Synovitis Score (GLOESS) for metacarpophalangeal joints (MCPs) 2–5, all joints (22 paired) and a reduced (9 paired) joint set. The predictive value of changes in GLOESS at week 1–16 evaluations for clinical status and response (Disease Activity Score (DAS)28 (C reactive protein, CRP) <2.6; DAS28(CRP) ≤3.2; DAS28(CRP) ≥1.2 improvement) up to week 24, and correlations between DAS28 and GLOESS were assessed.ResultsEighty-nine patients completed the 24-week treatment period. Changes in GLOESS (MCPs 2–5) from weeks 1 to 16 were unable to predict DAS28 outcomes up to week 24. However, significant improvements in GLOESS (MCPs 2–5) were observed at week 12 in patients with DAS28 ≥1.2 improvement at week 24 versus those who did not achieve that clinical response. In patients achieving DAS28 ≥1.2 improvement or DAS28 ≤3.2 at week 24, changes in GLOESS (22 and 9 paired joint sets) were greater in patients who already achieved DAS28 ≥1.2 at week 12 than in those who did not. No significant correlations were found between changes in DAS28 and GLOESS definitions at any time point.ConclusionsPDUS was not correlated with clinical status or response as measured by DAS28-derived criteria, and PDUS changes were not predictive of clinical outcome. The discrepancies require further exploration.Trial registration numberNCT00767325; Results.
Outcome After Thrombectomy and Intravenous Thrombolysis in Patients With Acute Ischemic Stroke
Authors: Minnerup Jens , Wersching Heike , Teuber Anja , Wellmann Jürgen , Eyding Jens , Weber Ralph , Reimann Gernot , Weber Werner , Krause Lars Udo , Kurth Tobias , Berger Klaus ,   for the REVASK Investigators, Homberg V. , Petrovitch A. , Heuser L. , Mönnigs P. , Krogias C. , Wallner B. , Hennigs S. , Ahlers A. , Sahl H. , Ranft A. , Dobis C. , Brassel F. , Nolden-Koch M. , Schmitt H. , Chapot R. , Nordmeyer H. , Schlamann M. , Weimar C. , Busch F. , Busch E.W. , Sigges E. , Ruf H. , Wohlfahrt K. , Karatschai R. , Klein B. , Höhle T. , Haass A. , Nasreldein A. , Büchele B. , Gahn G. , Sterker M. , Hantel T. , Krämer C. , Henningsen H. , Adelt I. , König M. , Schmidt C. , Hofmann A. , Niederstadt T. , Unrath M. , Rehfeldt T. , Fauser B. , Pfeiffer A. , Lowens S. , Stögbauer F. , Staudacher T. , Erdmann P. , Grotemeyer K.H. , Spüntrup E. , Bücke P. , Wienecke P. , Faiss J. , Wolzik-Großmann M. , Brune N. , Isenmann S. , Thomas C. , Mucha D. 
Published: May 2016

Background and Purpose—
In patients with ischemic stroke, randomized trials showed a better functional outcome after endovascular therapy with new-generation thrombectomy devices compared with medical treatment, including intravenous thrombolysis. However, effects on mortality and the generalizability of results to routine clinical practice are uncertain.

Methods—
In a prospective observational register-based study patients with ischemic stroke treated either with thrombectomy, intravenous thrombolysis, or their combination were included. Primary outcome was the modified Rankin scale score (0 [no symptoms] to 6 [death]) at 3 months. Ordinal logistic regression was used to estimate the common odds ratio as treatment effects (shift analysis). Propensity score matching was applied to compare patients treated either with intravenous thrombolysis alone or with intravenous thrombolysis plus thrombectomy.

Results—

Among 2650 recruited patients, 1543 received intravenous thrombolysis, 504 underwent thrombectomy, and 603 received intravenous thrombolysis in combination with thrombectomy. Later time-to-treatment was associated with worse outcomes among patients treated with thrombectomy plus thrombolysis. In 241 pairs of propensity score–matched patients with a proximal intracranial occlusion, thrombectomy plus thrombolysis was associated with improved functional outcome (common odds ratio, 1.84; 95% confidence interval, 1.32–2.57), and reduced mortality (15% versus 33%;
P
<0.0001) compared with intravenous thrombolysis alone. Results were similar in various sensitivity analyses accounting for missing outcome data and different analytic methods.

Conclusions—
Results from this large prospective registry show that also in routine clinical care thrombectomy plus thrombolysis compared with thrombolysis alone improved functional outcome and reduced mortality in patients with ischemic stroke. Earlier treatment was associated with better outcomes.
S4: An O2R/R2O Infrastructure for Optimizing Satellite Data Utilization in NOAA Numerical Modeling Systems: A Step Toward Bridging the Gap between Research and Operations
Authors: Boukabara Sid A. , Zhu Tong , Tolman Hendrik L. , Lord Steve , Goodman Steven , Atlas Robert , Goldberg Mitch , Auligne Thomas , Pierce Bradley , Cucurull Lidia , Zupanski Milija , Zhang Man , Moradi Isaac , Otkin Jason , Santek David , Hoover Brett , Pu Zhaoxia , Zhan Xiwu , Hain Christopher , Kalnay Eugenia , Hotta Daisuke , Nolin Scott , Bayler Eric , Mehra Avichal , Casey Sean P. F. , Lindsey Daniel , Grasso Louie , Kumar V. Krishna , Powell Alfred , Xu Jianjun , Greenwald Thomas , Zajic Joe , Li Jun , Li Jinliong , Li Bin , Liu Jicheng , Fang Li , Wang Pei , Chen Tse-Chun 
Published: May 2016

Abstract
In 2011, the National Oceanic and Atmospheric Administration (NOAA) began a cooperative initiative with the academic community to help address a vexing issue that has long been known as a disconnection between the operational and research realms for weather forecasting and data assimilation. The issue is the gap, more exotically referred to as the “valley of death,” between efforts within the broader research community and NOAA’s activities, which are heavily driven by operational constraints. With the stated goals of leveraging research community efforts to benefit NOAA’s mission and offering a path to operations for the latest research activities that support the NOAA mission, satellite data assimilation in particular, this initiative aims to enhance the linkage between NOAA’s operational systems and the research efforts. A critical component is the establishment of an efficient operations-to-research (O2R) environment on the Supercomputer for Satellite Simulations and Data Assimilation Studies (S4). This O2R environment is critical for successful research-to-operations (R2O) transitions because it allows rigorous tracking, implementation, and merging of any changes necessary (to operational software codes, scripts, libraries, etc.) to achieve the scientific enhancement. So far, the S4 O2R environment, with close to 4,700 computing cores (60 TFLOPs) and 1,700-TB disk storage capacity, has been a great success and consequently was recently expanded to significantly increase its computing capacity. The objective of this article is to highlight some of the major achievements and benefits of this O2R approach and some lessons learned, with the ultimate goal of inspiring other O2R/R2O initiatives in other areas and for other applications.
A Global Ocean Observing System for Measuring Sea Level Atmospheric Pressure: Effects and Impacts on Numerical Weather Prediction
Authors: Centurioni Luca , Horányi András , Cardinali Carla , Charpentier Etienne , Lumpkin Rick 
Published: May 2016

Abstract
Since 1994 the U.S. Global Drifter Program (GDP) and its international partners cooperating within the Data Buoy Cooperation Panel (DBCP) of the World Meteorological Organization (WMO) and the United Nations Education, Scientific and Cultural Organization (UNESCO) have been deploying drifters equipped with barometers primarily in the extratropical regions of the world’s oceans in support of operational weather forecasting. To date, the impact of the drifter data isolated from other sources has never been studied. This essay quantifies and discusses the effect and the impact of in situ sea level atmospheric pressure (SLP) data from the global drifter array on numerical weather prediction using observing system experiments and forecast sensitivity observation impact studies. The in situ drifter SLP observations are extremely valuable for anchoring the global surface pressure field and significantly contributing to accurate marine weather forecasts, especially in regions where no other in situ observations are available, for example, the Southern Ocean. Furthermore, the forecast sensitivity observation impact analysis indicates that the SLP drifter data are the most valuable per-observation contributor of the Global Observing System (GOS). All these results give evidence that surface pressure observations of drifting buoys are essential ingredients of the GOS and that their quantity, quality, and distribution should be preserved as much as possible in order to avoid any analysis and forecast degradations. The barometer upgrade program offered by the GDP, under which GDP-funded drifters can be equipped with partner-funded accurate air pressure sensors, is a practical example of how the DBCP collaboration is executed. Interested parties are encouraged to contact the GDP to discuss upgrade opportunities.
Improving High-Impact Forecasts through Sensitivity-Based Ensemble Subsets: Demonstration and Initial Tests
Authors: Ancell Brian C. 
Published: May 2016

AbstractEnsemble sensitivity can reveal features in the flow at early forecast times that are relevant to the predictability of chosen high-impact forecast aspects (e.g., heavy precipitation) later in time. In an operational environment, it thus might be possible to choose ensemble subsets with improved predictability over the full ensemble if members with the smallest errors in regions of large ensemble sensitivity can be identified. Since numerous observations become available hourly, such a technique is feasible and could be executed well before the next assimilation/extended forecast cycle, potentially adding valuable lead time to forecasts of high-impact weather events. Here, a sensitivity-based technique that chooses subsets of forecasts initialized from an 80-member ensemble Kalman filter (EnKF) is tested by ranking 6-h errors in sensitive regions toward improving 24-h forecasts of landfalling midlatitude cyclones on the west coast of North America. The technique is first tested within an idealized framework with one of the ensemble members serving as truth. Subsequent experiments are performed in more realistic scenarios with an independent truth run, observation error added, and sparser observations. Results show the technique can indeed produce ensemble subsets that are improved relative to the full ensemble for 24-h forecasts of landfalling cyclones. Forecast errors are found to be smallest when the greatest 70% of ensemble sensitivity magnitudes with subsets of size 5–30 members are used, as well as when only the cases of the largest forecast spread are considered. Finally, this study presents considerations for extending this technique into fully realistic situations with regard to additional high-impact events.
Different percentages of false-positive results obtained using five methods for the calculation of reference change values based on simulated normal and ln-normal distributions of data
Authors: Lund Flemming , Petersen Per Hyltoft , Fraser Callum G , Sölétormos György 
Published: May 2016

Background Reference change values provide objective tools to assess the significance of a change in two consecutive results for a biomarker from an individual. The reference change value calculation is based on the assumption that within-subject biological variation has random fluctuation around a homeostatic set point that follows a normal (Gaussian) distribution. This set point (or baseline in steady-state) should be estimated from a set of previous samples, but, in practice, decisions based on reference change value are often based on only two consecutive results. The original reference change value was based on standard deviations according to the assumption of normality, but was soon changed to coefficients of variation (CV) in the formula (reference change value = ± Z ċ 2½ ċ CV). Z is being dependent on the desired probability of significance, which also defines the percentages of false-positive results. The aim of this study was to investigate false-positive results using five different published methods for calculation of reference change value. Methods The five reference change value methods were examined using normally and ln-normally distributed simulated data. Results One method performed best in approaching the theoretical false-positive percentages on normally distributed data and another method performed best on ln-normally distributed data. The commonly used reference change value method based on two results (without use of estimated set point) performed worst both on normally distributed and ln-normally distributed data. Conclusions The optimal choice of method to calculate reference change value limits requires knowledge of the distribution of data (normal or ln-normal) and, if possible, knowledge of the homeostatic set point.
Bartering for a Compatible Kidney Using Your Incompatible, Live Kidney Donor: Legal and Ethical Issues Related to Kidney Chains
Authors: Tenenbaum Evelyn M. 
Published: May 2016

Kidney chains are a recent and novel method of increasing the number of available kidneys for transplantation and have the potential to save thousands of lives. However, because they are novel, kidney chains do not fit neatly within existing legal and ethical frameworks, raising potential barriers to their full implementation.Kidney chains are an extension of paired kidney donation, which began in the United States in 2000. Paired kidney donations allow kidney patients with willing, but incompatible, donors to swap donors to increase the number of donor/recipient pairs and consequently, the number of transplants. More recently, transplant centers have been using non-simultaneous, extended, altruistic donor (“NEAD”) kidney chains—which consist of a sequence of donations by incompatible donors—to further expand the number of donations. This Article fully explains paired kidney donation and kidney chains and focuses on whether NEAD chains are more coercive than traditional kidney donation to a family member or close friend and whether NEAD chains violate the National Organ Transplant Act's prohibition on the transfer of organs for valuable consideration.
Perinatal Health of Women with Intellectual and Developmental Disabilities and Comorbid Mental Illness
Authors: Brown Hilary K. , Cobigo Virginie , Lunsky Yona , Dennis Cindy-Lee , Vigod Simone 
Published: May 2016

Objective: Women with intellectual and developmental disabilities (IDD) have high rates of adverse perinatal outcomes. However, the perinatal health of women with co-occurring IDD and mental illness (dual diagnosis) is largely unknown. Our objectives were to 1) describe a cohort of women with dual diagnosis in terms of their social and health characteristics and 2) compare their risks for adverse maternal and neonatal outcomes to those of women with IDD only. Method: We conducted a population-based study using linked Ontario (Canada) health and social services administrative data to identify singleton obstetric deliveries to women with dual diagnosis ( n = 2080) and women with IDD only ( n = 1852; 2002–2012). Primary maternal outcomes were gestational diabetes, gestational hypertension, preeclampsia/eclampsia, and venous thromboembolism. Primary neonatal outcomes were preterm birth, small for gestational age, and large for gestational age. We also examined several secondary outcomes. Results: Women with dual diagnosis were more likely than women with IDD only to live in poor neighborhoods and to have prepregnancy health conditions; however, they had more frequent prenatal care. Infants born to women with dual diagnosis had increased risks for preterm birth (adjusted relative risk [aRR] 1.31, 95% confidence interval [CI] 1.08 to 1.59) and neonatal morbidity (aRR 1.35, 95% CI 1.03 to 1.76) compared with infants born to women with IDD only. All other primary and secondary outcomes were nonsignificant. Conclusions: Comorbid mental illness contributes little additional risk for adverse perinatal outcomes among women with IDD. Women with dual diagnosis and women with IDD alone require increased surveillance for maternal and neonatal complications.