bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages
Authors: Peterson Teresa E. , Kirkpatrick Nathaniel D. , Huang Yuhui , Farrar Christian T. , Marijt Koen A. , Kloepper Jonas , Datta Meenal , Amoozgar Zohreh , Seano Giorgio , Jung Keehoon , Kamoun Walid S. , Vardam Trupti , Snuderl Matija , Goveia Jermaine , Chatterjee Sampurna , Batista Ana , Muzikansky Alona , Leow Ching Ching , Xu Lei , Batchelor Tracy T. , Duda Dan G. , Fukumura Dai , Jain Rakesh K. 
Published: April 2016

Significance
Inhibition of the VEGF/VEGF receptor (VEGFR) pathway has failed to increase overall survival in phase III trials in patients with glioblastoma (GBM). Previously we identified the angiopoietin-2 (Ang-2)/TEK receptor tyrosine kinase (Tie-2) pathway as a potential driver of resistance to VEGF inhibition in GBM. Here we show that dual inhibition of VEGFRs and Ang-2 inhibits tumor growth and prolongs vessel normalization compared with VEGFR inhibition alone, resulting in improved survival in murine GBM models. Furthermore, by blocking macrophage recruitment, we demonstrate that macrophages contribute to the beneficial effects of dual therapy.
The quantum needle of the avian magnetic compass
Authors: Hiscock Hamish G. , Worster Susannah , Kattnig Daniel R. , Steers Charlotte , Jin Ye , Manolopoulos David E. , Mouritsen Henrik , Hore P. J. 
Published: April 2016

SignificanceBillions of birds fly thousands of kilometers every year between their breeding and wintering grounds, helped by an extraordinary ability to detect the direction of the Earth’s magnetic field. The biophysical sensory mechanism at the heart of this compass is thought to rely on magnetically sensitive, light-dependent chemical reactions in cryptochrome proteins in the eye. Thus far, no theoretical model has been able to account for the <5° precision with which migratory birds are able to detect the geomagnetic field vector. Here, using computer simulations, we show that genuinely quantum mechanical, long-lived spin coherences in realistic models of cryptochrome can provide the necessary precision. The crucial structural and dynamical molecular properties are identified.
Monoclonal antibody therapy for Junin virus infection
Authors: Zeitlin Larry , Geisbert Joan B. , Deer Daniel J. , Fenton Karla A. , Bohorov Ognian , Bohorova Natasha , Goodman Charles , Kim Do , Hiatt Andrew , Pauly Michael H. , Velasco Jesus , Whaley Kevin J. , Altmann Friedrich , Gruber Clemens , Steinkellner Herta , Honko Anna N. , Kuehne Ana I. , Aman M. Javad , Sahandi Sara , Enterlein Sven , Zhan Xiaoguo , Enria Delia , Geisbert Thomas W. 
Published: April 2016

Significance
There are no Food and Drug Administration approved drugs available for preventing or treating Argentine hemorrhagic fever (AHF), and the current treatment option is limited to administration of immune plasma. With the expanding clinical use of monoclonal antibodies (mAbs) for acute and chronic conditions, it has become clear that mAbs offer a highly specific, potent, and generally safe drug platform for antivirals, and may be a useful alternative to immune plasma. Here, we show that mAbs are effective in the Junin virus guinea pig model and likely to be an economical therapy for AHF.
The identification of post-starburst galaxies at z ∼ 1 using multiwavelength photometry: a spectroscopic verification
Authors: Maltby David T. , Almaini Omar , Wild Vivienne , Hatch Nina A. , Hartley William G. , Simpson Chris , McLure Ross J. , Dunlop James , Rowlands Kate , Cirasuolo Michele 
Published: April 2016

Abstract
Despite decades of study, we still do not fully understand why some massive galaxies abruptly switch off their star formation in the early Universe, and what causes their rapid transition to the red sequence. Post-starburst galaxies provide a rare opportunity to study this transition phase, but few have currently been spectroscopically identified at high redshift (z &gt; 1). In this paper, we present the spectroscopic verification of a new photometric technique to identify post-starbursts in high-redshift surveys. The method classifies the broad-band optical–near-infrared spectral energy distributions (SEDs) of galaxies using three spectral shape parameters (supercolours), derived from a principal component analysis of model SEDs. When applied to the multiwavelength photometric data in the UKIDSS Ultra Deep Survey, this technique identified over 900 candidate post-starbursts at redshifts 0.5 &lt; z &lt; 2.0. In this study, we present deep optical spectroscopy for a subset of these galaxies, in order to confirm their post-starburst nature. Where a spectroscopic assessment was possible, we find the majority (19/24 galaxies; ∼80 per cent) exhibit the strong Balmer absorption (H δ equivalent width Wλ &gt; 5 Å) and Balmer break, characteristic of post-starburst galaxies. We conclude that photometric methods can be used to select large samples of recently-quenched galaxies in the distant Universe.
Jean-Luc Godard
Authors: Morrey Douglas 
Published: April 2016

Few filmmakers have attracted as much academic and critical writing as Jean-Luc Godard. Perhaps only Alfred Hitchcock is comparable in terms of the sheer number of scholars who have approached his work over three or four generations. Unlike Hitchcock, Godard has spawned few imitators among other film directors. Godard’s style is so idiosyncratic that, still today, hardly any films could truthfully be described as “like Godard.” Godard scholarship is comparable to Hitchcock criticism, however, in that it has been the privileged site, over the past half century, for the development of key ideas, arguments, and theories within film studies. Godard’s own writing as a critic in the 1950s contributed to the development of key concepts in film theory, such as the auteur, montage, and mise-en-scène. The French New Wave, one of the most significant movements in global film history, would certainly not have had the same revolutionary impact on French and world cinemas without Godard’s first features. Godard’s work has been frequently cited by scholars seeking to catalogue the stylistic tendencies of a broadly defined “art cinema”: Godard’s films changed the way we think about narration, editing, mise-en-scène, sound and music, and work with actors. Godard’s departure from “mainstream” cinema in 1968 to experiment with collective filmmaking with an explicitly revolutionary Marxist agenda was a central inspiration to theorists in the 1970s and beyond in debating the forms and functions of political cinema. The director’s early experiments with video in the 1970s have enabled scholars to think through the relations among cinema, video, and television. The celebrated works of Godard’s return to 35mm filmmaking in the early 1980s helped generate certain key questions of representation that have resonated in film studies ever since: What is the relationship of film to painting? Under what conditions can cinema represent the sacred? Is it possible to conceive of a new way of filming bodies and sexuality (especially women’s bodies) without being complicit in exploitative conventions? The monumental Histoire(s) du Cinéma (1998) contributed to debates around the centenary of cinema, the medium’s much-heralded “death,” and its replacement by digital progeny. Godard’s most recent features—Film socialisme (2010) and Adieu au langage (2014)—have attracted immediate critical acclaim for their unparalleled formal innovation while tackling the contemporary political context of the global financial crisis. With such a rich legacy of work, the field of Godard studies will, without doubt, continue to grow rapidly in the decades to come.
“Is Voice A Marker for Autism Spectrum Disorder? A Systematic Review And Meta-Analysis”
Authors: Fusaroli Riccardo , Lambrechts Anna , Bang Dan , Bowler Dermot M , Gaigg Sebastian B 
Published: April 2016

AbstractLay AbstractIndividuals with Autism Spectrum Disorder (ASD) are reported to speak in distinctive ways. Distinctive vocal production should be better understood as it can affect social interactions and social development and could represent a noninvasive marker for ASD. We systematically review the existing scientific literature reporting quantitative acoustic analysis of vocal production in ASD and identify repeated and consistent findings of higher pitch mean and variability but not of other differences in acoustic features. We also identify a recent approach relying on multiple aspects of vocal production and machine learning algorithms to automatically identify ASD from voice only. This latter approach is very promising, but requires more systematic replication and comparison across languages and contexts. We outline three recommendations to further develop the field: open data, open methods, and theory-driven research.Scientific AbstractIndividuals with Autism Spectrum Disorder (ASD) tend to show distinctive, atypical acoustic patterns of speech. These behaviours affect social interactions and social development and could represent a non-invasive marker for ASD. We systematically reviewed the literature quantifying acoustic patterns in ASD. Search terms were: (prosody OR intonation OR inflection OR intensity OR pitch OR fundamental frequency OR speech rate OR voice quality OR acoustic) AND (autis* OR Asperger). Results were filtered to include only: empirical studies quantifying acoustic features of vocal production in ASD, with a sample size > 2, and the inclusion of a neurotypical comparison group and/or correlations between acoustic measures and severity of clinical features. We identified 34 articles, including 30 univariate studies and 15 multivariate machine-learning studies. We performed meta-analyses of the univariate studies, identifying significant differences in mean pitch and pitch range between individuals with ASD and comparison participants (Cohen's d of 0.4–0.5 and discriminatory accuracy of about 61–64%). The multivariate studies reported higher accuracies than the univariate studies (63–96%). However, the methods used and the acoustic features investigated were too diverse for performing meta-analysis. We conclude that multivariate studies of acoustic patterns are a promising but yet unsystematic avenue for establishing ASD markers. We outline three recommendations for future studies: open data, open methods, and theory-driven research.
Potential pitfalls in estimating viral load heritability
Authors: Leventhal Gabriel E. , Bonhoeffer Sebastian 
Published: April 2016

AbstractIn HIV patients, the set-point viral load (SPVL) is the most widely used predictor of disease severity. Yet SPVL varies over several orders of magnitude between patients. The heritability of SPVL quantifies how much of the variation in SPVL is due to transmissible viral genetics. There is currently no clear consensus on the value of SPVL heritability, as multiple studies have reported apparently discrepant estimates. Here we illustrate that the discrepancies in estimates are most likely due to differences in the estimation methods, rather than the study populations. Importantly, phylogenetic estimates run the risk of being strongly confounded by unrealistic model assumptions. Care must be taken when interpreting and comparing the different estimates to each other.
Devoted to you my love: brand devotion amongst young consumers in emerging Indian market
Authors: Sarkar Abhigyan , Sarkar Juhi Gahlot 
Published: April 2016

Purpose
Research investigating brand devotion among young consumers is scarce particularly in emerging Asian market context. The objective of this study was to qualitatively explore the evolutionary process leading to brand devotion amongst the young Indian consumers.

Design/methodology/approach
Semi-structured depth interviews were conducted to collect data. Data was analyzed using grounded theory method.

Findings
The grounded theory framework developed shows single brand devotion in a product category as the key phenomenon along with the associated factors and evolutionary processes.

Originality/value
This study explores how single brand devotion is distinct from romantic brand love, as experienced by consumers. Value of this article also lies in developing a grounded theory framework for single brand devotion in emerging Asian market context.
The moderating effects of single vs multiple-grounds of perceived-discrimination on work-attitudes
Authors: Baruch Yehuda , Humbert Anne Laure , Wilson Doirean 
Published: April 2016

Purpose– Moving from a focus on a single aspect of diversity to multiple-diversity characteristics, the purpose of this paper is to develop and empirically test a model that examines whether self-efficacy (SE) and protean career (PC) measures relate to intention to stay (ITS), as a possible mediation of job satisfaction (JS). The authors then explored whether perceived discrimination – on single and multiple grounds – modify these relationships.Design/methodology/approach– A survey of 316 US managers, of which 95 reported perceived discrimination: 51 perceived discrimination on a single ground and a further 44 on multiple grounds.Findings– SE and PC are associated with increased ITS where there is higher JS. Furthermore, multiple discrimination results in more negative outcomes compared to a single source of perceived discrimination.Research limitations/implications– Employees with multiple diversities might be more prone to feelings of discrimination, which in an organizational context that lacks diversity awareness can generate negative implications on performance, esteem, working relationships, and ultimately ITS.Originality/value– The research provides valuable insights into the issue of diversity and discrimination relating to more than one single source of diversity.
Exploring the social identity threat response framework
Authors: Holmes IV Oscar , Whitman Marilyn V. , Campbell Kim S. , Johnson Diane E. 
Published: April 2016

Purpose
– The purpose of this paper is to explore what individuals perceive as social identity threats, the sources of the threat, individuals’ responses, and the consequences of the threat.

Design/methodology/approach
– Narratives from 224 individuals were collected. A sample of 84 narratives were analyzed in depth using a qualitative content analysis approach.

Findings
– Initial support for identity threat response theory was found. Three new distinct threat responses – constructive action, ignore, and seek assistance – were uncovered. Additionally, harm/loss appraisals were found to be perceived and reacted to similarly to Petriglieri-defined identity threats.

Originality/value
– This study contributes to identity scholarship by shedding further light on the “theoretical black box” associated with identity threat. Such insight is necessary in further enhancing our understanding of the impact that identity threat has at the individual and organizational level.
Reflections on organizational team diversity research
Authors: Schoenung Benjamin , Dikova Desislava 
Published: April 2016

Purpose– Research on organizational team diversity operates under the assumption that team diversity matters for organizational team behavior. The purpose of this paper is to outline this assumption by referring to three aspects which this type of research has conventionally employed, that is, the conceptual definition, IPO logic, and the concept’s operationalization. The authors subsequently search for its logical support.Design/methodology/approach– The search covers several pieces of information: the possible origins of organizational team diversity research, models on group composition, and models on collective behavior.Findings– The authors do not find strong evidence in favor of the field’s assumption.Originality/value– The implications of this are put into context with contemporary research practices and diversity’s popularity.
The contribution of subjective measures to the quantification of social progress
Authors: Messner Wolfgang 
Published: April 2016

Purpose
– Statistical indicators, such as human health, are important for designing government policies, as well as for influencing the functioning of economic markets. However, there is often a discrepancy between statistical measures and the citizens’ prevalent feelings. In order to produce more relevant indicators of social progress, governments are currently shifting their measurement emphasis from objective to subjective measures. While the philosophical tradition of hedonic psychology views individuals as the best judges of their own conditions, little empirical evidence shows that individually reported health scores provide accurate information about a population’s health status. The purpose of this paper is to evaluate if subjective health questions contain genuine information about the status of human health, and are meaningful at an aggregated level.

Design/methodology/approach
– Subjective health data are extracted from the 2012/2013 European Social Survey (28 European countries plus Israel, n=54,427). Objective health data are based on the 2012 World Bank statistics for life expectancy at birth. The author check if aggregated subjective health correlates with life expectancy at country level, and can reliably be compared across countries.

Findings
– The findings support the idea of including subjective data into country statistics of social progress. Because of substantial between-country differences, social development programs should be devised individually for each country.

Originality/value
– By showing that subjective health measures can reliably contribute to the quantification of social progress, the author offer a bridge between objective neoclassical economics and subjective hedonic psychology.
Between rights and obligations – rethinking youth participation at the margins
Authors: Määttä Mirja , Aaltonen Sanna 
Published: April 2016

Purpose– The purpose of this paper is to offer a critical view of participatory policies and measures by highlighting that participation is not only a right for young people, but also an obligation for many. This obligated participation is studied conceptually and empirically.Design/methodology/approach– The paper introduces a novel typology of youth participation that demonstrates the dimensions of institutional framing and a degree of choice in participation. The typology is applied in an empirical study on how the participation rights and obligations are formed and handled within an educational programme, aiming to support young people at the margins.Findings– Young people are controlled by their participation obligations, and are guided to reach maturity and claim personal responsibility for their choices. The acceptance of an obligation to participate has to be negotiated with young people in services; otherwise they may opt out of supportive measures.Research limitations/implications– More research is needed on how youth participation terminology is used in political programmes and professional practices.Social implications– It is vital to discuss the options and obligations of young people in professional support measures and consider their implications for different groups of young people. At the policy level, the challenge is to ensure that the right to participate at community and political levels is not ignored or made inaccessible to young people at the margins.Originality/value– The typology diversifies understanding of youth participation and enables the analysis of participation types. It can be applied in youth studies, policy-making and practices.
Does sophisticated DCF outperform heuristics driven PE? Evidence from India
Authors: SAYED SAMIE AHMED 
Published: April 2016

Purpose
PE and DCF are two popular valuation methodologies used by analysts to derive target price forecasts while performing equity research. Recent studies in developed markets show that analysts using sophisticated models like DCF produce more accurate target price forecasts as compared to heuristics driven models like PE. This study investigates if analysts using DCF outperform analysts using PE in an emerging market institutional set up.

Design/methodology/approach
An in-depth analysis of 392 equity research reports is conducted to understand the dominant valuation model used by analysts to derive target price forecasts. Research reports with clear mention of valuation methodology (PE or DCF) to derive target price forecast are used for the purpose of performing this analysis. Multivariate OLS and logit regression analysis has been conducted to investigate if analysts using DCF outperform analysts using PE to derive target price forecasts.

Findings
The study finds that analysts using PE produce significantly better short-term results than analysts using DCF i.e. when target price accuracy is measured anytime during forecast horizon of 12 months. However, there is no significant difference in target price performance or target price forecast error of PE and DCF model when analyst performance is measured at the end of the forecast horizon.

Practical implications
In contrast to results from developed markets, this study does not find evidence of superior target price performance of DCF. On the contrary, results suggest that PE outperforms DCF on the short-term measure of target price accuracy. This study shows that PE model which captures market moods and sentiments effectively is more suitable in dynamic, emerging markets like India.

Originality/value
Past studies have explored the performance of PE and DCF in developed markets and this study provides fresh empirical evidence on target price accuracy of valuation model from an emerging market like India. The superior short-term target price performance of PE as compared to DCF may be relevant exclusively in emerging markets like India.
Examining US principal perception of multiple leadership styles used to practice shared instructional leadership
Authors: Urick Angela 
Published: April 2016

Purpose
– Decades of research on different leadership styles shows that effective school leadership is the degree of influence or synergy between teachers and principals around the core business of schools, instruction. While various styles, such as transformational, instructional, shared instructional, point to the similar measures of high organizational quality, the inconsistency in how these styles are defined and relate make it unclear how principals systematically improve schools. The paper aims to discuss these issues.

Design/methodology/approach
– This study used the 1999-2000 schools and staffing survey, n=8,524 of US principals, since it includes a nationally representative sample of administrators who responded to a comprehensive set of leadership measures around a time of school restructuring reforms. Confirmatory factor analysis was used to identify different styles, and to measure the extent of their relationship. These factors were used to test a theory about why principals practice each of these styles to a different degree based on levels of shared instructional leadership.

Findings
– Based on the theoretical framework, principals should have a similar high influence over resources, safety and facilities regardless of degree of shared instructional leadership since these tasks address foundational school needs. However, principal and teacher influence over these resources differed across levels of shared instructional leadership more than principal-directed tasks of facilitating a mission, supervising instruction and building community.

Originality/value
– Differences in the practice of styles by shared instructional leadership did not fit changing, higher ordered needs as theorized instead seemed to vary by a hierarchy of control, the way in which principals shared influence with teachers.