bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near-infrared Variability of Obscured and Unobscured X-Ray-selected AGNs in the COSMOS Field
Authors: Sánchez P. , Lira P. , Cartier R. , Pérez V. , Miranda N. , Yovaniniz C. , Arévalo P. , Milvang-Jensen B. , Fynbo J. , Dunlop J. , Coppi P. , Marchesi S. 
Published: November 2017

Abstract
We present our statistical study of near-infrared (NIR) variability of X-ray-selected active galactic nuclei (AGNs) in the COSMOS field, using UltraVISTA data. This is the largest sample of AGN light curves in YJHKs
bands, making it possible to have a global description of the nature of AGNs for a large range of redshifts and for different levels of obscuration. To characterize the variability properties of the sources, we computed the structure function. Our results show that there is an anticorrelation between the structure function A parameter (variability amplitude) and the wavelength of emission and a weak anticorrelation between A and the bolometric luminosity. We find that broad-line (BL) AGNs have a considerably larger fraction of variable sources than narrow-line (NL) AGNs and that they have different distributions of the A parameter. We find evidence that suggests that most of the low-luminosity variable NL sources correspond to BL AGNs, where the host galaxy could be damping the variability signal. For high-luminosity variable NL sources, we propose that they can be examples of “true type II” AGNs or BL AGNs with limited spectral coverage, which results in missing the BL emission. We also find that the fraction of variable sources classified as unobscured in the X-ray is smaller than the fraction of variable sources unobscured in the optical range. We present evidence that this is related to the differences in the origin of the obscuration in the optical and X-ray regimes.
L’impact de la T2A sur la gestion des établissements publics de santé
Authors: Burnel Philippe 
Published: November 2017

Le présent article a pour objet de faire un point, après 12 ans de mise en œuvre, sur les effets induits par la tarification à l’activité (T2A) sur la gestion et l’organisation des établissements publics de santé (EPS). Il met en évidence, en s’appuyant sur la littérature, que les effets attendus en termes d’efficience ne se sont que partiellement réalisés. Les EPS n’ont pas révisé en profondeur leurs processus et leurs organisations se contentant de mesures d’ajustement sur les charges variables. Il s’ensuit une dégradation des conditions de travail et une perte de sens qui affecte les personnels soignants et, parfois médicaux. Pour dépasser ces limites, cet article explore les voies d’un approche réellement médico-économique centrée sur la refonte des processus de prise en charge en se fondant sur ce qui motive l’action des personnels soignants : les dynamiques du progrès médical qui offre des opportunités nouvelles et la recherche de l’amélioration de la qualité des soins.
Le débat sur le « moral bioenhancement » entre dressage & perfectionnement
Authors: Adorno Francesco Paolo 
Published: November 2017

Les discours et pratiques relevant de l’augmentation de notre volonté morale ( moral enhancement ) par voie médicamenteuse illustrent un cas où la volonté de réussir pousse la volonté à reconnaître ses limites physiologiques. Dès lors que nos choix résultent, entre autres choses, de certains taux de neurotransmetteurs dans nos cerveaux, l’absorption de certaines substances chimiques peut nous aider à « mieux vouloir », c’est-à-dire à choisir ce que nous ne choisissons pas spontanément, mais que nous devrions vouloir choisir, si notre désir (subjectif) pouvait s’aligner sur notre intérêt (objectif). Cette morale médicamentée prétend court-circuiter notre volonté spontanée pour imposer cet alignement par la force irrésistible de la chimie.
Les media du XXI e siècle
Authors: Hansen Mark B. N. , Citton Yves 
Published: November 2017

Un nouveau type de media, propres au XXI e siècle, ne s’adresse plus à nos consciences, ni même à nos perceptions, mais vise à connecter automatiquement différents points de sensibilité du monde (y compris au sein de notre propre corps), sans plus s’adresser à des « sujets » humains. L’internet des objets a pour vocation de fonctionner tout seul, sans se laisser entraver par l’erratisme des volontés subjectives, ni ralentir par les aléas de délibérations collectives – comme une vaste architecture de choix agencés pour notre bien, mais par des programmes. C’est bien un nouveau type de médialité qu’il faut reconnaître ici, appelant de nouveaux types d’interventions.
Existe-t-il des territoires kanak ?
Authors: Pantz Pierre-Christophe 
Published: November 2017

Depuis plusieurs décennies, la relation fusionnelle des Kanaks avec leur terre ancestrale a été mise en lumière par les sciences humaines. Mais s’agit-il pour autant de territoires , définis d’un point de vue occidental comme des espaces agis, appropriés et délimités par des frontières ? Dans la culture et les langues kanak, le terme de territoire n’existe pas selon cette acception. De la période pré-coloniale, où ils étaient apparentés à un réseau de lieux, de chemins et de géosymboles, jusqu’à la période coloniale, où l’administration a voulu les transformer en réserves, les territoires kanak ont subi de profondes recompositions, qui rendent nécessaires de nouveaux outils conceptuels : ceux de territorialité et de territorialisation.
HIPAA, HIPAA, Hooray?: Current Challenges and Initiatives in Health Informatics in the United States
Authors: Joshi Sanjaya 
Published: November 2017

A review of the current challenges, trends and initiatives around the various regulations as related to Health Informatics in the United States is presented. A summary of the functions in a workflow-based approach organized into the process and compliance for HIPAA, secure email and fax communications interfaces, e-prescriptions and patient safety and the health information technology savings claims versus costs follows: • HIPAA compliance is complex; data interoperability and integration remains difficult. • Email and faxing is possible with current over-the-shelf technologies within the purview of the HIPAA Security and Privacy rule. • Integration of e-prescribing and NPI data is an area where health informatics can make a real difference. • Medical errors remain high. • There are no real savings yet from the usage of health information technologies; the costs for implementation remain high, and the business model has not evolved to meet the needs. • Health Information Technology (Health IT) projects continue to have a significant failure rate; Open Source technologies are a viable alternative both for cost reduction and scalability. A discussion on the macro view of health informatics is also presented within the context of healthcare models and a comparison of the U.S. system against other countries.
Artificial Neural Networks for Early Prediction of Mortality in Patients with Non Variceal Upper GI Bleeding (UGIB)
Authors: Grossi Enzo , Marmo Riccardo , Intraligi Marco , Buscema Massimo 
Published: November 2017

Background Mortality for non variceal upper gastrointestinal bleeding (UGIB) is clinically relevant in the first 12–24 hours of the onset of haemorrhage and therefore identification of clinical factors predictive of the risk of death before endoscopic examination may allow for early corrective therapeutic intervention. Aim 1) Identify simple and early clinical variables predictive of the risk of death in patients with non variceal UGIB; 2) assess previsional gain of a predictive model developed with conventional statistics vs. that developed with artificial neural networks (ANNs). Methods and Results Analysis was performed on 807 patients with nonvariceal UGIB (527 males, 280 females), as a part of a multicentre Italian study. The mortality was considered “bleeding-related” if occurred within 30 days from the index bleeding episode. A total of 50 independent variables were analysed, 49 of which clinico-anamnestic, all collected prior to endoscopic examination plus the haemoglobin value measured on admission in the emergency department. Death occurred in 42 (5.2%). Conventional statistical techniques (linear discriminant analysis) were compared with ANNs (Twist® system-Semeion) adopting the same result validation protocol with random allocation of the sample in training and testing subsets and subsequent cross-over. ANNs resulted to be significantly more accurate than LDA with an overall accuracy rate near to 90%. Conclusion Artificial neural networks technology is highly promising in the development of accurate diagnostic tools designed to recognize patients at high risk of death for UGIB.
Low Serum Alpha-1 Antitrypsin (AAT) in Family Members of Individuals with Autism Correlates with PiMZ Genotype
Authors: Russo Anthony J. , Neville Lauren , Wroge Christine 
Published: November 2017

AimDeficiency of Alpha-1-antitrypsin (AAT) can be a genetic condition that increases the risk of developing liver, lung and possibly gastrointestinal disease. Since many autistic children also have gastrointestinal disorders, this study was designed to measure serum concentration of AAT and establish AAT genotypes in autistic children, age and gender matched non-autistic siblings, parents and controls.Subjects and MethodsWe used an indirect ELISA with monoclonal IgG to AAT to measure AAT serum concentrations in 71 members from 16 families of individuals with autism and 18 controls (no family history of autism). We used a duplex polymerase chain reaction to detect M, S and Z alleles for alpha-1 antitrypsin expression in 52 members of 12 of the above families.ResultsA significantly high number of autistic family members had lower than normal serum levels of AAT when compared to controls. Autistic children with regressive onset had significantly lower levels of AAT compared to controls, and a significant number of autistic children with low serum AAT also had hyperbilirubinemia, gastrointestinal disease and respiratory problems. We also found that a significantly high number of these individuals had the PiMZ genotype and correspondingly low levels of serum alpha-1 antitrypsin.DiscussionKnowing that low levels of alpha-1 antitrypsin may be inherited, and that low levels of AAT may be associated with GI disease in autistic children, genotyping autistic children may help identify individuals susceptible to developing digestive problems.
Breath Hydrogen Gas Concentration Linked to Intestinal Gas Distribution and Malabsorption in Patients with Small-bowel Pseudo-obstruction
Authors: Urita Yoshihisa , Watanabe Toshiyasu , Maeda Tadashi , Sasaki Yosuke , Ishihara Susumu , Hike Kazuo , Sanaka Masaki , Nakajima Hitoshi , Sugimoto Motonobu 
Published: November 2017

Summary Background The patient with colonic obstruction may frequently have bacterial overgrowth and increased breath hydrogen (H2) levels because the bacterium can contact with food residues for longer time. We experienced two cases with intestinal obstruction whose breath H2 concentrations were measured continuously. Case 1 A 70-year-old woman with small bowel obstruction was treated with a gastric tube. When small bowel gas decreased and colonic gas was demonstrated on the plain abdominal radiograph, the breath H2 concentration increased to 6 ppm and reduced again shortly. Case 2 A 41-year-old man with functional small bowel obstruction after surgical treatment was treated with intravenous administration of erythromycin. Although the plain abdominal radiograph demonstrated a decrease of small-bowel gas, the breath H2 gas kept the low level. After a clear-liquid meal was supplied, fasting breath H2 concentration increased rapidly to 22 ppm and gradually decreased to 9 ppm despite the fact that the intestinal gas was unchanged on X-ray. A rapid increase of breath H2 concentration may reflect the movement of small bowel contents to the colon in patients with small-bowel pseudo-obstruction or malabsorption following diet progression. Conclusions Change in breath H2 concentration had a close association with distribution and movement of intestinal gas.
Pathway Analysis of Differentially Expressed Genes in Patients with Acute Aortic Dissection
Authors: Mohamed Salah A. , Sievers Hans H. , Hanke Thorsten , Richardt Doreen , Schmidtke Claudia , Charitos Efstratios I. , Belge Gazanfer , Bullerdiek Joern 
Published: November 2017

BackgroundAcute aortic dissection (AAD) is a life-threatening condition with high mortality and a relatively unclarified pathophysiological mechanism. Although differentially expressed genes in AAD have been recognized, interactions between these genes remain poorly defined. This study was conducted to gain a better understanding of the molecular mechanisms underlying AAD and to support the future development of a clinical test for monitoring patients at high risk.Materials and MethodsAortic tissue was collected from 19 patients with AAD (mean age 61.7 ± 13.1 years), and from eight other patients (mean age 32.9 ± 12.2 years) who carried the mutated gene for Marfan syndrome (MS). Six patients (mean age 56.7 ± 12.3 years) served as the control group. The PIQOR™ Immunology microarray with 1076 probes in quadruplicates was utilized; the differentially expressed genes were analysed in a MedScan search using PathwayAssist software. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and protein analysis were performed.ResultsInteractions of MS fibrillin-1 (FBN1) in the MedScan pathway analysis showed four genes, fibulin-1 (FBLN1), fibulin-2 (FBLN2), decorin (DCN) and microfibrillar associated protein 5 (MFAP5), which were differentially expressed in all tissue from AAD. The validation of these genes by qRT-PCR revealed a minimum of three-fold downregulation of FBLN1 (0.5 ± 0.4 vs. 6.1 ± 2.3 fold, p = 0.003) and of DCN (2.5 ± 1.0 vs. 8.5 ± 4.7 fold, p = 0.04) in AAD compared to MS and control samples.ConclusionsDownregulation of fibrillin-1 (FBN1) may weaken extracellular components in the aorta and/or interfer with the transmission of cellular signals and eventually cause AAD. Additional research on these four identified genes can be a starting point to develop a diagnostic tool.
Possible Mitochondria-Associated Enzymatic Role in Non-Hodgkin Lymphoma Residual Disease
Authors: Kusao Ian , Troelstrup David , Shiramizu Bruce 
Published: November 2017

Background The mechanisms responsible for resistant or recurrent disease in childhood non-Hodgkin lymphoma (NHL) are not yet fully understood. A unique mechanism suggesting the role of the mitochondria as the key energy source responsible for residual cells has been assessed in the clinical setting on specimens from patients on therapy were found to have increased copies of mitochondrial DNA (mtDNA) associated with positive minimal residual disease and/or persistent disease (MRD/PD) status. The potential role of mtDNA in MRD/PD emphasizes queries into the contributions of relevant enzymatic pathways responsible for MRD/PD. This study hypothesized that in an in-vitro model, recovering or residual cells from chemotoxicity will exhibit an increase in both citrate synthase and isocitrate dehydrogenase expression and decrease in succinate dehydrogenase expression. Procedure Ramos cells (Burkitt lymphoma cell line) were exposed to varying concentrations of doxorubicin and vincristine for 1 hr; and allowing for recovery in culture over a 7-day period. cDNA was extracted on days 1 and 7 of the cell culture period to assess the relative expression of the aforementioned genes. Results Increase citrate synthase, increase isocitrate dehydrogenase and decrease succinate dehydrogenase expressions were found in recovering Ramos cells. Conclusion Recovering lymphoma cells appear to compensate by regulating enzymatic levels of appropriate genes in the Krebs Cycle suggesting an important role of the mitochondria in the presence of residual cells.
Equipamiento de laboratorio para mejorar el aprendizaje en comunicaciones móviles
Authors: Díaz Zayas Almudena , Rivas Tocado Francisco Javier , Merino Pedro 
Published: November 2017

Se espera que las generaciones venideras degraduados e investigadores de ingeniería desarrollen un conjunto integral de habilidades para adaptarse a la industria delas comunicaciones móviles y a las expectativas del mercado.Para satisfacer estas demandas las universidades tendrán que colaborar e innovar en sus estilos de educación, herramientas de investigación y procesos de aprendizaje. La evolución de la experimentación remota y la disponibilidad de sistemasavanzados de pruebas para comunicaciones móviles ofrecen nuevas oportunidades, como la experimentación con la clase Gigabit LTE-A. En este artículo discutimos cómo este equipo podría ser adoptado con fines educativos y cómo se pueden usar tecnologías de acceso a entornos de investigación federados para proporcionar un acceso remoto y controlado.
Modelo de colas con vacations aplicado a un sistema de captura de paquetes
Authors: Zabala Luis , Ferro Armando , Nieva Ander 
Published: November 2017

La mejora de sistemas de captura de paquetes de red ha sido extensamente cubierta como tema de investigación en los pasados años. La mayoría de estas iniciativas han sido respaldadas por evaluaciones experimentales; sin embargo, ha habido pocas propuestas de modelado. Este trabajo presenta el modelado y el análisis de un sistema de cola finito con vacations aplicado a la etapa de captura de paquetes de un sistema de monitorización de red. Se plantean dos modelos con disciplina de servicio diferente (exhaustiva y limitada) y se evalúan sus rendimientos, principalmente en forma de throughput de captura, para distintos escenarios. Éstos contemplan diferentes tasas de entrada de paquetes y tiempos de vacation. Los resultados teóricos, derivados de un estudio analítico basado en ecuaciones de balance y su desarrollo en forma matricial, también son comparados con los de una sonda real de tráfico de red que captura paquetes.
Red de Sensores Inalámbricos de Bajo Consumo Energético en Agricultura Hidropónica
Authors: Jimenez Jose Miguel , Cambra Carlos , Sendra Sandra , Lloret Jaime 
Published: November 2017

Debido a los cambios medioambientales, aumento demográfico o incluso la propia volatilidad de precios en los mercados, el sector agrícola necesita actualmente mejorar el manejo de los recursos agrarios. Las nuevas tecnologías son clave para mejorar la sostenibilidad en el sector agrícola y producir alimentos con calidad alimentaria contrastada. En los últimos años España está sufriendo etapas de escasez de agua y zonas semiáridas dedicadas a la horticultura sufren estos efectos, por lo que los agricultores se ven obligados a trasladar sus cultivos a zonas más húmedas que en muchas ocasiones, presentan condiciones climatológicas menos adecuadas. Gracias a la tecnología podemos monitorizar y crear entornos con condiciones ambientales idóneas mediante el uso de invernaderos, que nos permiten la producción de alimentos controlando todo tipo de parámetros ambientales, nutricionales y de la propia planta. En este artículo presentamos el desarrollo de una red de sensores móviles orientada a monitorizar los patrones de necesidades de las plantas y tomar decisiones inteligentes según la captación de datos ambientales obtenida. La red está compuesta por nodos sensores comunicados con tranceptores de radio distribuidos en una red mallada, que podría ser fácilmente dapatada a cualquier tipo de uso a petición del profesional. Esta red ha sido probada en un entorno de agricultura hidropónica. Finalmente el paper muestra los resultados obtenidos en cuanto a tráfico generado, lo que nos permitirá en un futuro, hacer la red escalable..
Technical Note: Corrosion Fatigue Crack Growth of Forged Type 316NG Austenitic Stainless Steel in 325°C Water
Authors: Xiao J. , Chen L.Y. , Zhou J. , Qiu S.Y. , Chen Y. 
Published: November 2017

Forged Type 316NG austenitic stainless steel is commonly used to fabricate primary coolant pipe in advanced pressurized water reactor systems, but it is subject to corrosion fatigue cracking in primary coolant environments. In this study, the fatigue crack growth of Type 316NG austenitic stainless steel in 325°C water was investigated. The corrosion fatigue effect in 325°C water was mainly correlated to the crack growth rate and load frequency. A maximum Fen (environment corrected factor) value up to 100 was observed at f = 0.005 Hz, ΔK = 13 MPa√m. The dissolved oxygen tended to have little influence on the fatigue crack growth. The crack path was deflected and branched. Most secondary cracks tended to be initiated from grain boundaries.
Ensemble prediction of air quality using the WRF/CMAQ model system for health effect studies in China
Authors: Hu Jianlin , Li Xun , Huang Lin , Ying Qi , Zhang Qiang , Zhao Bin , Wang Shuxiao , Zhang Hongliang 
Published: November 2017

Abstract. Accurate exposure estimates are required for health effect analyses of severe air pollution in China. Chemical transport models (CTMs) are widely used to provide spatial distribution, chemical composition, particle size fractions, and source origins of air pollutants. The accuracy of air quality predictions in China is greatly affected by the uncertainties of emission inventories. The Community Multiscale Air Quality (CMAQ) model with meteorological inputs from the Weather Research and Forecasting (WRF) model were used in this study to simulate air pollutants in China in 2013. Four simulations were conducted with four different anthropogenic emission inventories, including the Multi-resolution Emission Inventory for China (MEIC), the Emission Inventory for China by School of Environment at Tsinghua University (SOE), the Emissions Database for Global Atmospheric Research (EDGAR), and the Regional Emission inventory in Asia version 2 (REAS2). Model performance of each simulation was evaluated against available observation data from 422 sites in 60 cities across China. Model predictions of O3 and PM2.5 generally meet the model performance criteria, but performance differences exist in different regions, for different pollutants, and among inventories. Ensemble predictions were calculated by linearly combining the results from different inventories to minimize the sum of the squared errors between the ensemble results and the observations in all cities. The ensemble concentrations show improved agreement with observations in most cities. The mean fractional bias (MFB) and mean fractional errors (MFEs) of the ensemble annual PM2.5 in the 60 cities are −0.11 and 0.24, respectively, which are better than the MFB (−0.25 to −0.16) and MFE (0.26–0.31) of individual simulations. The ensemble annual daily maximum 1 h O3 (O3-1h) concentrations are also improved, with mean normalized bias (MNB) of 0.03 and mean normalized errors (MNE) of 0.14, compared to MNB of 0.06–0.19 and MNE of 0.16–0.22 of the individual predictions. The ensemble predictions agree better with observations with daily, monthly, and annual averaging times in all regions of China for both PM2.5 and O3-1h. The study demonstrates that ensemble predictions from combining predictions from individual emission inventories can improve the accuracy of predicted temporal and spatial distributions of air pollutants. This study is the first ensemble model study in China using multiple emission inventories, and the results are publicly available for future health effect studies.