bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling of terracette‐hillslope soil moisture as a function of aspect, slope and vegetation in a semi‐arid environment
Authors: Corrao Mark V. , Link Timothy E. , Heinse Robert , Eitel Jan U.H. 
Published: January 2017

AbstractIn the semi‐arid western United States, water availability plays a defining role in land use. Soil moisture, vegetation, and microtopography are key variables in the hydrologic function of these ecosystems. Previous research has not addressed the influence of site‐specific aspect, vegetation, or slope gradient on terracette soil moisture patterns in semi‐arid rangelands. Therefore, the objectives of this study were to: (1) assess the influence of terracette site aspect, vegetation cover, and slope on soil moisture; (2) conceptualize conditions at the hillslope scale given terracette morphology; and (3) estimate the extent of terracettes at a regional scale. The Simultaneous Heat and Water (SHAW) model was used to simulate soil water dynamics of terracettes given variations in site conditions. These results were coupled with time‐of‐flight laser scans to quantify terracette bench and riser percent‐area, and statewide assessments of terracette extent using digital orthoimagery and a geographical information system (GIS). Modeling results indicated site aspect had minimal influence (±0.005 m3 m−3) on terracette soil moisture. Vegetation, represented as leaf area index (LAI), had the single‐most influential effect on terracette volumetric water content (θv) demonstrated by an inverse relationship of LAI to mean terracette hillslope θv; and slope increases of ≥15% on northern azimuths increased mean θv which contrasted with southern azimuths for similar slope increases. Laser scanning results indicated bench width and riser length could be estimated from mean site slope (R2 = 0.82 risers and R2 = 0.93 benches). Aerial orthoimagery/GIS assessments estimated >159 000 ha of terracettes throughout the State of Idaho, with >41 000 ha (~26%) occurring on lands managed as grazing allotments. These findings provide an increased understanding of rangeland hydrologic processes as influenced by cattle density, vegetation, and terracettes which can aide land managers in their selection and application of best management practices on these lands. Copyright © 2017 John Wiley & Sons, Ltd.
An assessment of direct and indirect effects of two herbicides on aquatic communities
Authors: Hasenbein Simone , Lawler Sharon P. , Connon Richard E. 
Published: January 2017

Abstract

Herbicides are often detected in watersheds at concentrations that are toxic to phytoplankton, potentially causing indirect effects on higher trophic organisms. The long-term effects of 5 applications over 30 d of binary mixtures of the herbicides diuron and hexazinone were assessed at “low” and “high” concentrations typically found in the environment, using mesocosms. Sixteen of 95 phytoplankton taxa, 3 of 18 zooplankton taxa, and 6 of 14 macroinvertebrate taxa responded negatively to contaminant exposures. Herbicide applications altered the phytoplankton community structure. Relative abundance of Cyanophyceae decreased following 5 applications from 52.1% in the control to 37.3% in the low treatment and to 25.9% in the high treatment, while Chlorophyceae increased to 50.6% in the low treatment and to 61.7% in the high treatment compared with the control (39.7%). Chlorophyceae had the greatest number of affected species (8), whereas 1 species within the Cyanophyceae was negatively affected on more than 1 sampling day. Further, chlorophyll a was reduced on 4 and 5 d out of the 8 total sampling days in the low and high treatments, respectively, compared with the control. These results highlight that integrating multiple taxa and contaminants with long-term exposures in ecological risk assessments of herbicides can facilitate the ability to make predictive and mechanistic generalizations about the role of herbicides in shaping patterns of species abundance in natural systems. Environ Toxicol Chem 2017;36:2234–2244. © 2017 SETAC
Inhibition of immune responses and related proteins in Rhamdia quelen exposed to diclofenac
Authors: Ribas João L.C. , Sherry James P. , Zampronio Aleksander R. , Silva de Assis Helena C. , Simmons Denina B.D. 
Published: January 2017

Abstract

Nonsteroidal anti-inflammatory drugs are among the most widely detected pharmaceuticals in surface water worldwide. The nonsteroidal anti-inflammatory drug diclofenac is used to treat many types of pain and inflammation. Diclofenac's potential to cause adverse effects in exposed wildlife is a growing concern. To evaluate the effects of waterborne diclofenac on the immune response in Rhamdia quelen (South American catfish), fish were exposed to 3 concentrations of diclofenac (0.2, 2.0, and 20.0 μg/L) for 14 d. Some of the exposed fish were also given an intraperitoneal injection on day 14 of 1 mg/kg of carrageenan to evaluate cell migration to the peritoneum. Total blood leukocyte count and carrageenan-induced leukocyte migration to the peritoneal cavity, particularly of polymorphonuclear cells, were significantly affected for all diclofenac exposure groups. Nitric oxide production was significantly reduced in the diclofenac-treated fish. Plasma and kidney proteins were analyzed by means of liquid chromatography–tandem mass spectrometry in a shotgun proteomic approach. In both plasma and kidney of diclofenac-exposed R. quelen, the expression of 20 proteins related to the inflammatory process, nitric oxide production, leukocyte migration, and the complement cascade was significantly altered. In addition, class I major histocompatibility complex was significantly decreased in plasma of diclofenac-treated fish. Thus, waterborne exposure to diclofenac could lead to suppression of the innate immune system in R. quelen. Environ Toxicol Chem 2017;36:2092–2107. © 2017 SETAC
Imperfect (de)convolution may introduce spurious psychophysiological interactions and how to avoid it
Authors: Di Xin , Reynolds Richard C. , Biswal Bharat B. 
Published: January 2017

AbstractPsychophysiological interaction (PPI) is a widely used regression‐based method to study connectivity changes in different experimental conditions. A PPI effect is generated by point‐by‐point multiplication of a psychological variable (experimental design) and a physiological variable (time series of a seed region). If the psychological variable is non‐centered with a constant component, the constant component will add a physiological variable to the PPI term. The physiological component would in theory be accounted for by the physiological main effect in the model. But due to imperfect deconvolution and convolution with hemodynamic response function, the physiological component in PPI may no longer be exactly the same as the physiological main effect. This issue was illustrated by analyzing two block‐designed fMRI datasets, one simple visual checkerboard task and a set of different tasks designed to activate different hemispheres. When PPI was calculated with deconvolution but without centering, significant results were usually observed between regions that are known to have baseline functional connectivity. These results could be suppressed by simply centering the psychological variable when calculating the PPI term or adding a deconvolve–reconvolved version of the physiological covariate. The PPI results with centering and with deconvolve–reconvolved physiological covariate are consistent with an explicit test for differences in coupling between conditions. It was, therefore, suggested that centering of the psychological variable or the addition of a deconvolve–reconvolved covariate is necessary for PPI analysis. Hum Brain Mapp 38:1723–1740, 2017. © 2017 Wiley Periodicals, Inc.
Intramolecular Excited‐State Hydrogen Transfer in Rutin and Quercetin
Authors: Simkovitch Ron , Huppert Dan 
Published: January 2017

AbstractSteady‐state and time‐resolved optical spectroscopy techniques were employed to study the excited‐state intramolecular hydrogen transfer (ESIHT) in rutin, a flavonol that contains a disaccharide and is a natural product in plants. The results are compared with those of a similar natural compound, quercetin, which also has a flavonol structure. The fluorescence decay signal of the normal form of these two compounds is composed of three time components. The ESIHT rate in both compounds has a time constant of 70 fs or less. The ESIHT processes of both compounds show a distinctive kinetic isotope effect of 1.5 or more. The intermediate and long‐time components are about 300 fs and a few picoseconds, respectively, for both compounds. The amplitude of the intermediate component in rutin is twice that of quercetin. We explain this difference as arising from the hydrogen bonding of the glucose in rutin to the ESIHT active site.
Oxidative Stress Promotes Doxorubicin‐Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions
Authors: Pinzón‐Daza Martha L. , Cuellar‐Saenz Yenith , Nualart Francisco , Ondo‐Mendez Alejandro , Del Riesgo Lilia , Castillo‐Rivera Fabio , Garzón Ruth 
Published: January 2017

ABSTRACTP‐glycoprotein (Pgp) and breast cancer resistance protein (BCRP) are ATP binding cassette (ABC) transporters that are overexpressed in different drug‐resistant cancer cell lines. In this study, we investigated whether doxorubicin promotes Pgp and/or BCRP expression to induce drug resistance in colon cancer cells under hypoxic conditions. We analyzed HIF‐1α activity via ELISA, Pgp, and BCRP expression by qRT‐PCR and the relationship between doxorubicin uptake and ABC transporter expression via confocal microscopy in HT‐29WT and HT‐29 doxorubicin‐resistant colon cancer cells (HT‐29DxR). These cells were treated with doxorubicin and/or CoCl2 (chemical hypoxia), and reactive oxygen species inductors. We found that the combination of chemically induced hypoxia and doxorubicin promoted Pgp mRNA expression within 24 h in HT‐29WT and HT‐29DxR cells. Both doxorubicin and CoCl2 alone or in combination induced Pgp and BCRP expression, as demonstrated via confocal microscopy in each of the above two cell lines. Thus, we surmised that Pgp and BCRP expression may result from synergistic effects exerted by the combination of doxorubicin‐induced ROS production and HIF‐1α activity under hypoxic conditions. However, HIF‐1α activity disruption via the administration of E3330, an APE‐1 inhibitor, downregulated Pgp expression and increased doxorubicin delivery to HT‐29 cells, where it served as a substrate for Pgp, indicating the existence of an indirect relationship between Pgp expression and doxorubicin accumulation. Thus, we concluded that Pgp and BCRP expression can be regulated via cross‐talk between doxorubicin and hypoxia, promoting drug resistance in HT‐29 WT, and HT‐29DxR cells and that this process may be ROS dependent. J. Cell. Biochem. 118: 1868–1878, 2017. © 2017 Wiley Periodicals, Inc.
Therapeutic Potential of Curcumin in Treatment of Pancreatic Cancer: Current Status and Future Perspectives
Authors: Hosseini Mina , Hassanian Seyed Mahdi , Mohammadzadeh Elham , ShahidSales Soodabeh , Maftouh Mina , Fayazbakhsh Hasan , Khazaei Majid , Avan Amir 
Published: January 2017

ABSTRACTPancreatic cancer is among the leading cause of deaths due to cancer with extremely poor prognosis. Gemcitabine is being used in the treatment of patient with pancreatic ductal adenocarcinoma (PDAC), although, the response rate is bellow 12%. A recent phase III trial revealed that FOLFIRINOX could be an option for the treatment of metastatic PDAC patients, although it is associated with increased toxicity. Therefore, identification of novel agents that either improves gemcitabine activity, within novel combinatorial approaches, or with a better efficacy than gemcitabine is warranted. The antitumor activity of curcumin in several tumors, including prostate, breast and colorectal cancers have investigated. A recent phase II trial explored the effects of curcumin in advanced pancreatic cancer patient. They found that oral curcumin was well tolerated. Another trial showed the activity of 8,000 mg of curcumin in combination with gemcitabine in patients with advanced pancreatic cancer. This review summarizes the current knowledge about possible molecular mechanisms of curcumin in PDAC with particular emphasis on preclinical/clinical studies in pancreatic cancer treatment. J. Cell. Biochem. 118: 1634–1638, 2017. © 2017 Wiley Periodicals, Inc.
Establishment of reference intervals for complete blood count parameters during normal pregnancy in Beijing
Authors: Li Aiwei , Yang Shuo , Zhang Jie , Qiao Rui 
Published: January 2017

ObjectiveTo observe the changes of complete blood count (CBC) parameters during pregnancy and establish appropriate reference intervals for healthy pregnant women.MethodsHealthy pregnant women took the blood tests at all trimesters. All blood samples were processed on Sysmex XE‐2100. The following CBC parameters were analyzed: red blood cell count (RBC), hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), white blood cell count (WBC), and leukocyte differential count. Reference intervals were established using the 2.5th and 97.5th percentile of the distribution.ResultsComplete blood count parameters showed dynamic changes during trimesters. RBC, Hb, Hct declined at trimester 1, reaching their lowest point at trimester 2, and began to rise again at trimester 3. WBC, neutrophil count (Neut), monocyte count (MONO), RDW, and PDW went up from trimester 1 to trimester 3. On the contrary, MCHC, lymphocyte count (LYMPH), PLT, and MPV gradually descended during pregnancy. There were statistical significances in all CBC parameters between pregnant women and normal women, regardless of the trimesters (P<.001). The median obtained were (normal vs pregnancy) as follows: RBC 4.50 vs 3.94×1012/L, Hb 137 vs 120 g/L, WBC 5.71 vs 9.06×109/L, LYMPH% 32.2 vs 18.0, Neut% 58.7 vs 75.0, and PLT 251 vs 202×109/L.ConclusionThe changes of CBC parameters during pregnancy are described, and reference intervals for Beijing pregnant women are demonstrated in this study.
Spatiotemporal patterns of annual and seasonal precipitation extreme distributions across China and potential impact of tropical cyclones
Authors: Gu Xihui , Zhang Qiang , Singh Vijay P. , Liu Lin , Shi Peijun 
Published: January 2017

ABSTRACTStatistical properties of annual and seasonal daily maximum precipitation in terms of nonstationarity, upper tail properties, and impact of tropical cyclones (TCs) were analysed, using data from 728 meteorological stations across China andTCstracks data covering a period of 1951–2014. The change points and trends detected by stepwise regression method and modified Mann–Kendall, respectively, provide limited evidence of the violation of the stationarity assumption in both annual and seasonal extreme precipitation, and we cannot make conclusive statements about the presence of a possible climate change signal. For stationary stations, the ratio of scale to location parameters of generalized extreme value (GEV) distribution shows exponential for annual and seasonal extreme precipitation in some sub‐regions. On the other hand, annual and seasonal maxima point to an unbounded‐above and heavy‐tail behaviour, and discussion of these upper tail properties in light of mixtures of different rainfall‐generating mechanisms is provided. In addition, anomalous values of theGEVshape parameter are associated withTCsin controlling the upper tail of annual maxima on China's coastal areas with strong spatial heterogeneities.
Investigation into the role of endogenous abscisic acid during ripening of imported avocado cv. Hass
Authors: Meyer Marjolaine D , Chope Gemma A , Terry Leon A 
Published: January 2017

AbstractBACKGROUNDThe importance of ethylene in avocado ripening has been extensively studied. In contrast, little is known about the possible role of abscisic acid (ABA). The present work studied the effect of 1‐methylcyclopropene (1‐MCP) (0.3 μL L−1), e+® Ethylene Remover and the combination thereof on the quality of imported avocado cv. Hass fruit stored for 7 days at 12 °C. Ethylene production, respiration, firmness, colour, heptose (C7) sugars and ABA concentrations in mesocarp tissue were measured throughout storage.RESULTSTreatment with e+® Ethylene Remover reduced ethylene production, respiration rate and physiological ripening compared with controls. Fruit treated with 1‐MCP + e+® Ethylene Remover and, to a lesser extent 1‐MCP alone, had the lowest ethylene production and respiration rate and hence the best quality. Major sugars measured in mesocarp tissue were mannoheptulose and perseitol, and their content was not correlated with ripening parameters. Mesocarp ABA concentration, as determined by mass spectrometry, increased as fruit ripened and was negatively correlated with fruit firmness.CONCLUSIONSResults suggest a relationship between ABA and ethylene metabolism since blocking ethylene, and to a larger extent blocking and removing ethylene, resulted in lower ABA concentrations. Whether ABA influences avocado fruit ripening needs to be determined in future research. © 2017 Society of Chemical Industry
Role of microbial inoculation and industrial by‐product phosphogypsum in growth and nutrient uptake of maize (Zea mays L.) grown in calcareous soil
Authors: Al‐Enazy Abdul‐Aziz R , Al‐Oud Saud S , Al‐Barakah Fahad N , Usman Adel RA 
Published: January 2017

AbstractBACKGROUNDAlkaline soils with high calcium carbonate and low organic matter are deficient in plant nutrient availability. Use of organic and bio‐fertilizers has been suggested to improve their properties. Therefore, a greenhouse experiment was conducted to evaluate the integrative role of phosphogypsum (PG; added at 0.0, 10, 30, and 50 g PG kg−1), cow manure (CM; added at 50 g kg−1) and mixed microbial inoculation (Incl.; Azotobacter chroococcum, and phosphate‐solubilizing bacteria Bacillus megaterium var. phosphaticum and Pseudomonas fluorescens) on growth and nutrients (N, P, K, Fe, Mn, Zn and Cu) uptake of maize (Zea mays L.) in calcareous soil. Treatment effects on soil chemical and biological properties and the Cd and Pb availability to maize plants were also investigated.RESULTSApplying PG decreased soil pH. The soil available P increased when soil was inoculated and/or treated with CM, especially with PG. The total microbial count and dehydrogenase activity were enhanced with PG+CM+Incl. treatments. Inoculated soils treated with PG showed significant increases in NPK uptake and maize plant growth. However, the most investigated treatments showed significant decreases in shoot micronutrients. Cd and Pb were not detected in maize shoots.CONCLUSIONSApplying PG with microbial inoculation improved macronutrient uptake and plant growth. © 2017 Society of Chemical Industry
The impact of local control in the treatment of type II/III pleuropulmonary blastoma. Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS)
Authors: Sparber‐Sauer Monika , Seitz Guido , Kirsch Sylvia , Vokuhl Christian , Leuschner Ivo , Dantonello Tobias M. , Scheer Monika , von Kalle Thekla , Ljungman Gustaf , Bielack Stefan S. , Klingebiel Thomas , Fuchs Joerg , Koscielniak Ewa ,   on behalf of the CWS Study Group
Published: January 2017

Background and ObjectivesThis study aims at examining the potential survival benefits of primary versus secondary surgery in the management of children diagnosed with pleuropulmonary blastoma (PPB) type II/III.Patients and MethodsDisease characteristics, treatment, and survival of 29 children with localized PPB type II/III, treated in six prospective Cooperative Weichteilsarkom Studiengruppe (CWS) trials, were reviewed retrospectively.ResultsFive year event free survival (EFS) and overall survival (OS) of children treated according to CWS protocols was 72%. Patients with tumors ≤10 cm had a 5 year OS of 91% versus 57% in patients with tumors >10 cm (P = 0.025). Five year OS of patients with macroscopically incomplete upfront resections was 44% as opposed to 68% in patients with delayed/secondary microscopically or macroscopically complete resection after an initial biopsy (P = 0.476). Ten patients died of disease, one patient died of second malignancy. Tumor size and complete tumor resection at any time were significant prognostic factors (P = 0.025/0.003) for EFS. EFS for microscopically complete, microscopically incomplete, and macroscopically incomplete resection at any time was 91%, 90%, and 25%, respectively (P = 0.01).ConclusionsPrimary or secondary microscopically/macroscopically complete tumor resections in combination with chemotherapy correlates with long term survival in children with PPB. J. Surg. Oncol. 2017;115:164–172. © 2017 Wiley Periodicals, Inc.
Cost‐utility of osteoarticular allograft versus endoprosthetic reconstruction for primary bone sarcoma of the knee: A markov analysis
Authors: Wilson Robert J. , Sulieman Lina M. , VanHouten Jacob P. , Halpern Jennifer L. , Schwartz Herbert S. , Devin Clinton J. , Holt Ginger E. 
Published: January 2017

BACKGROUNDThe most cost‐effective reconstruction after resection of bone sarcoma is unknown. The goal of this study was to compare the cost effectiveness of osteoarticular allograft to endoprosthetic reconstruction of the proximal tibia or distal femur.METHODSA Markov model was used. Revision and complication rates were taken from existing studies. Costs were based on Medicare reimbursement rates and implant prices. Health‐state utilities were derived from the Health Utilities Index 3 survey with additional assumptions. Incremental cost‐effectiveness ratios (ICER) were used with less than $100 000 per quality‐adjusted life year (QALY) considered cost‐effective. Sensitivity analyses were performed for comparison over a range of costs, utilities, complication rates, and revisions rates.RESULTSOsteoarticular allografts, and a 30% price‐discounted endoprosthesis were cost‐effective with ICERs of $92.59 and $6 114.77. One‐way sensitivity analysis revealed discounted endoprostheses were favored if allografts cost over $21 900 or endoprostheses cost less than $51 900. Allograft reconstruction was favored over discounted endoprosthetic reconstruction if the allograft complication rate was less than 1.3%. Allografts were more cost‐effective than full‐price endoprostheses.CONCLUSIONSOsteoarticular allografts and price‐discounted endoprosthetic reconstructions are cost‐effective. Sensitivity analysis, using plausible complication and revision rates, favored the use of discounted endoprostheses over allografts. Allografts are more cost‐effective than full‐price endoprostheses.