bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial Technology and Literacy Shaping Students' Financial Management with Digital Literacy
Authors: Fadiyah Nur Laily , Widodo Heri 
Published: October 2024

Financial management behavior is crucial for students, particularly as they engage with evolving financial technologies. However, there is a limited understanding of how financial technology and financial literacy interact to shape financial behavior, especially when considering digital literacy as a moderating factor. This study addresses this knowledge gap by examining the roles of financial technology and financial literacy on students' financial management behavior, with digital literacy as a potential moderator. Using a quantitative research method, primary data were gathered through a questionnaire survey from a sample of 114 accounting students at Muhammadiyah University of Sidoarjo, class of 2020. The findings indicate a positive relationship between financial technology and financial literacy on financial management behavior. Furthermore, digital literacy was found to moderate the effect of financial technology, strengthening its influence on students' financial management behavior. However, digital literacy did not moderate the influence of financial literacy on financial management behavior. The novelty of this research lies in its exploration of digital literacy's role as a moderating variable. Implications suggest the importance of incorporating digital literacy into financial education programs to enhance students' financial management practices. Highlights: Positive Relationship: Financial technology and literacy improve students' financial management behavior. Moderating Role: Digital literacy strengthens the effect of financial technology on financial behavior. No Moderation: Digital literacy does not moderate the impact of financial literacy on behavior. Keywords: Financial Technology, Financial Literacy, Digital Literacy, Financial Management, Student Behavior
Innovative Solution for the Disposal of the Produced Water in the GoS Province
Authors: Dwiedar M. D. 
Published: October 2024

AbstractGulf of Suez is one of the largest provinces that produce oil in Egypt and Middle East. GOS oil reserve represents 46 % of Egypt's reserve where GOS oil production represents 23 % of Egypt's production. Water production rate in GOS is 500 Mbbl/day with salinity 80000 – 130000 ppm that represents an environmental hazard. There are different alternatives for disposing this large amount of produced water such as underground disposal, water injection, and using it in tertiary recovery methods. In this research, I will explain the three different alternatives that exist for disposing the produced water accompanying the produced oil in the GOS. Moreover, I will elaborate an innovative solution for this important issue. This solution depends on desalination of produced water using different desalination techniques until getting the desired salinity 40000 ppm that is environmentally accepted and using the large amount of waste brine from desalination to create sodium hydroxide. The brine-to-caustic process is shown to be technically feasible while oﬀering several advantages, that is, the reduced environmental impact of desalination through lessened brine discharge, and the increase in the overall water recovery ratio of the reverse osmosis facility. Additionally, best-use conditions are given for producing caustic not only for use within the plant, but also in excess amounts for potential revenue.
Improving adherence to the Guidelines on Nutritional Support in a Neonatal Intensive Care Unit: Association with an Electronic Health Records Implementation
Authors: Grelon Camille , Yverneau Mathilde , Prodhomme Mathilde , Coursin Arnaud , Delange Boris , Beuchée Alain 
Published: October 2024

Abstract

The aim of the study was to measure compliance with parenteral nutrition guidelines after the implementation of individualized prescription software forextremely low-birth-weight preterm infants and the impact of these guidelines on postnatal growth at 36weeks.
Materials and methods: All newborns with a birthweight of less than 1000 g who were born between January 2012 and December 2015 (period A),between January 2019 and September 2021 (period B), without malformation or congenital anomalies, and admitted to the University Hospital of Rennes within the first 24 hours of life were included. Adherence to the ESPGHAN recommendations wascompared between Periods A and B. Caloric and protein intakes were considered adequate if both the median caloric and protein intakes over days 5 to 7 were in agreement with the 2018 ESPGHAN recommendations. The association between thedelta Z score andweight at birth and at 36 weeks was assessed by multivariate analysis after weighting for the propensity score for adequate early intake.
Results: Following the implementation of individualized prescription software, adherence to the ESPGHAN recommendations significantly increased. In period B, there was 82% adherence tothe protein intake recommendations from D5 to D7 and 63% agreement for total calories. A correlation was observed between inadequate intake and postnatal growth failure.
Conclusion: The deployment of individualized prescription software with responsive calculations of anticipated intakes was associated with an improvement inthe accuracy ofparenteral nutrition guidelines for preterm infants.
Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy
Authors: He Siyu , Li Chunyu , Lu Mingxin , Lin Fang , Hu Sangyu , Peng Luying , Li Li 
Published: October 2024

Abstract

Background
Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the progression of DCM and associated immunotherapeutic approaches.
Methods
We constructed a single-cell transcriptional atlas of DCM and normal patients. Then, the xCell algorithm, EPIC algorithm, MCP counter algorithm, and CIBERSORT method were applied to identify DCM-related cell types with a high degree of precision and specificity using RNA-seq datasets. We further analyzed the heterogeneity among cell types, performed trajectory analysis, examined transcription factor regulatory networks, investigated metabolic heterogeneity, and conducted intercellular communication analysis. Finally, we used bulk RNA-seq data to confirm the roles of M2-like2 subpopulations and GAS6 in DCM.
Results
We integrated and analyzed Single-cell sequencing (scRNA-seq) data from 7 DCM samples and 3 normal heart tissue samples, totaling 70,958 single-cell data points. Based on gene-specific expression and prior marker genes, we identified 9 distinct subtypes, including fibroblasts, endothelial cells, myeloid cells, pericytes, T/NK cells, smooth muscle cells, neuronal cells, B cells, and cardiomyocytes. Using machine learning methods to quantify bulk RNA-seq data, we found significant differences in fibroblasts, T cells, and macrophages between DCM and normal samples. Further analysis revealed high heterogeneity in tissue preference, gene expression, functional enrichment, immunodynamics, transcriptional regulatory factors, metabolic changes, and communication patterns in fibroblasts and myeloid cells. Among fibroblast subpopulations, proliferative F3 cells were implicated in the progression of DCM, while myofibroblast F6 cells promoted the transition from DCM to heart failure. Additionally, two subpopulations of M2 macrophages, M2-like1 and M2-like2, were identified with distinct features. The M2-like2 cell subpopulation, which was enriched in glycolysis and fatty acid metabolism, involved in inflammation inhibition and fibrosis promotion. Cell‒cell communication analysis indicated the GAS6-MERTK axis might exhibit interaction between M2 macrophage and M2-like1 macrophage. Furthermore, deconvolution analysis for bulk RNA-seq data revealed a significant increase in M2-like2 subpopulations in DCM, suggesting a more important role for this cell population in DCM.
Conclusions
We revealed the heterogeneity of non-cardiomyocytes in DCM and identified subpopulations of myofibroblast and macrophages engaged in the progression of DCM, which suggested a potential significance of non-cardiomyocytes in treatment of DCM.
Community Support, Self-Management Behavior, and The Effectiveness of Chronic Disease Management: Evidence from China
Authors: Wang Xiaohui , Wang Jingru , Miao Haimin 
Published: October 2024

Abstract

Community support plays a crucial role in community chronic disease management, but there is still a lack of analysis of the role testing mechanism based on the Chinese context. Based on CHARLS (2018), explore the impact of community support on the effectiveness of patient chronic disease management. The results showed that community support significantly promoted the control effect of chronic disease patients, and self-management behavior played a part of the mesomeric effect. Through multidimensional analysis, the mediating role of daily life management is minimal, while professional guidance has the greatest mediating effect. A community chronic disease support system centered on patient self-management should be established, and efforts should be made to improve the health promotion strategies for community chronic disease management.
The tradition of washing hands in a common bowl before eating: a qualitative study of the practice of communal bowl hand rinsing before mealtimes, in rural and urban Mali
Authors: Asamane Evans Atiah , Adams Rachel L , Poole Chloe , Sidibe Cheick , Diarra Youssouf , Diarra Hawa , Yazdani Mariam , Bajaj Mitali , Sfeir Selina , Weber Katinka , Toure Ousmane , Gale Nicola , Manaseki-Holland Semira 
Published: October 2024

Abstract

Background
Diarrhoeal disease is a leading cause of death in children under 5 years old globally, despite being largely preventable. It is widely known that individual handwashing with soap is key in preventing transmission of enteric pathogens. Communal bowl hand rinsing (CB-HR) is the act of two or more people washing hands in a shared bowl of water without the use of soap, and without changing the water between individuals; this remains a commonplace cultural practice in many African countries. It occurs before household mealtimes, at gatherings and in schools. Evidence demonstrates that communal water provides a reservoir for communicable diseases, however there is limited evidence about the motivations including the social and cultural norms underpinning its continued practice. The aim of this study was to gain a better understanding of public perspectives on CB-HR, identifying the reasoning and exploring the beliefs behind the practice and determining factors preventing the improvement of hand hygiene.
Methods
We recorded 59 semi-structured interviews and 26 focus groups, in the local language of Bambara, across both rural and urban communities in Mali. Participants included mothers, fathers, grandmothers and grandfathers. Recordings were transcribed into French, translated into English and analysed using thematic analysis.
Results
CB-HR was commonplace amongst our participants, they confirmed that CB-HR was rooted in tradition for the purposes of social cohesion and family unity. The exact way in which CB-HR was practised varied. There was wide awareness of the infection-related risks associated with CB-HR. Various reasons were given for not practising and maintaining individual handwashing with soap. Ways of combining CB-HR and individual handwashing with soap were described, including the need for role models to maintain motivation.
Conclusion
CB-HR was widespread in our rural & urban sample despite knowledge of its health risks, and access to running water and handwashing equipment (vessels and soap) because of the belief that it maintained social cohesion. Programmes aimed at improving infection control need to address the social and cultural drivers of CB-HR, or to adapt interventions in ways that are not perceived to threaten family unity.
Choroid Plexus Aging: Structural and Vascular Insights from the HCP-Aging Dataset
Authors: Sun Zhe , Li Chenyang , Zhang Jiangyang , Wisniewski Thomas , Ge Yulin 
Published: October 2024

Abstract

Background: The choroid plexus (ChP), a highly vascularized structure within the ventricles, is essential for cerebrospinal fluid (CSF) production and metabolic waste clearance, crucial for neurofluid homeostasis and cognitive function. ChP enlargement is seen in normal aging and neurodegenerative diseases like Alzheimer's disease (AD). Despite its key role of in the blood-CSF barrier (BCSFB), detailed studies on age-related changes in its perfusion and microstructure remain limited.
Methods: We analyzed data from 641 healthy individuals aged between 36 and 90, using the Human Connectome Project Aging (HCP-A) dataset. Volumetric, perfusion, and diffusion metrics of the ChP were derived from structural MRI, arterial spin labeling (ASL), and diffusion-weighted imaging (DWI), respectively. Partial correlations were used to explore age-related ChP changes, and independent t-tests to examine sex differences across age decades. One-way ANOVA was employed to compare perfusion characteristics among ChP, gray matter (GM), and white matter (WM). Relationships between volume, perfusion, and diffusion were investigated, adjusting for age and sex. Additionally, the distribution of cyst-like structures within the ChP and their diffusion/perfusion MRI characteristics were analyzed across different age groups.
Results: The ChP undergoes notable changes with age, including an increase in volume (r2 = 0.2, P < 0.001), a decrease in blood flow (r2 = 0.17, P < 0.001), and elevated mean diffusivity (MD) values (r2 = 0.16, P < 0.001). Perfusion characteristics showed significant differences between the ChP, GM, and WM (P < 0.001). Both the ChP and GM exhibited age-related declines in CBF, with a more pronounced decline in the ChP. A negative correlation was observed between the age-related increase in ChP volume and the decrease in CBF, suggesting compensatory dystrophic hyperplasia in response to perfusion decline. Cyst-like structures in ChP, characterized by lower MD and reduced CBF, were found to be more prevalent in older individuals.
Conclusions: Our findings provide a detailed quantitative assessment of age-related changes in ChP perfusion and diffusion, which may affect CSF production and circulation, potentially leading to waste solute accumulation and cognitive impairment.
Report and analysis of a rare case of missed and mistreated gastrointestinal bleeding secondary to gallbladder pseudoaneurysm
Authors: Zhu Zimo , Zhu Jun , Duan Jintao , Peng Min 
Published: October 2024

Abstract

This article analyses the diagnostic and treatment process of a case of chronic gallbladder stone cholecystitis secondary to gallbladder pseudoaneurysm formation and resulting in bleeding from an ulcer in the duodenal bulb with the aim of increasing clinicians' attention to the rupture and bleeding of a ruptured pseudoaneurysm of the gallbladder artery (CAP), diagnosis and timely treatment. Informed consent was obtained from the patient before writing this article.
Establishing Measurable Residual Disease Trajectories for Patients on Treatment for Newly Diagnosed Multiple Myeloma as Benchmark for Deployment of T-cell Redirection Therapy
Authors: Bal Susan , Magnusson Tylan , Ravi Gayathri , Giri Smith , Godby Kelly , Dhakal Binod , Callander Natalie , Silbermann Rebecca , Dholaria Bhagirathbhai , Reddy Vishnu , Costa Luciano 
Published: October 2024

Abstract

Autologous stem cell transplantation (ASCT) has been the prime consolidative strategy to increase the depth and duration of response in newly diagnosed multiple myeloma (NDMM), albeit with short- and long-term toxicities. Minimal residual disease (MRD) is an important early response endpoint correlating with clinically meaningful outcomes and may be used to isolate the effect of ASCT. We report the impact of ASCT on MRD burden and generate a benchmark for evaluation of novel treatments as consolidation. We collected MRD by next generation sequencing (NGS; clonoSEQ®) post induction and post-ASCT in consecutive patients (N = 330, quadruplet, N = 279; triplet, N = 51). For patients receiving quadruplets, MRD < 10− 5 post-induction was 29% (MRD < 10− 6 15%) increasing to 59% post-ASCT (MRD < 10− 6 45%). Among patients with MRD≥10− 5 post-induction, ASCT lowered the MRD burden≥1 log10 for 69% patients. The use of quadruplet induction (vs. triplet) did not reduce the effect of ASCT on MRD burden. Reduction in MRD burden with ASCT was most pronounced in patients with high-risk chromosome abnormalities. This dataset provides granular data to delineate the impact of ASCT on MRD as legacy consolidative strategy in NDMM and provides an important benchmark for evaluation of efficacy of TCRT as experimental consolidative strategy.
Exosomal Manf originated from endothelium regulated osteoclast differentiation by down- regulating NF-κB signaling pathway
Authors: Pi Zhilong , Wu You , Wang Xinyu , Li Pingyue , Wang Renkai 
Published: October 2024

Abstract

Background
Endothelium-derived exosomes has been reported to enhanced osteogenesis. However, the role of endothelial exosomes on osteoclastgenesis is still unknown.
Methods
Human umbilical vein endothelial cells (HUVECs) were used to isolate exosomes. PBS or HUVEC-Exos were used to treat RAW 264.7 cells. Then, the preconditioned RAW 264.7 cells were subjected to TRAP staining and RT-qPCR assays. In vivo, we constracted osteoporosis mice model. PBS or HUVEC-Exos were injected through tail vein after ovariectomy surgery. Bone mass was assessed by micro-CT and TRAP staining. Furthermore, we conducted RNA sequencing and found the genes that were differentially expressed.
Results
Osteoclast differentiation was inhibited by endothelium-derived exosomes in this study. Moreover, HUVEC-Exos demonstrated a specific action on bones to promote in vivo bone resorption. Furthermore, exosomal Manf promoted bone resorption via down-regulating NF-κB signaling, and HUVEC-Exos Manf inhibited osteoclast differentiation in vivo.
Conclusion
HUVEC-exosomal Manf suppressed osteoclastogenesis via down-regulating NF-κB signaling.
The Central Nervous System Tightly Controls Rollator-Supported Transitions Between Sitting and Standing
Authors: Herzog Michael , Krafft Frieder C. , Fiedler Janis , Berger Denise J. , Sloot Lizeth H. , d’Avella Andrea , Stein Thorsten 
Published: October 2024

Abstract

Background
Older individuals are at risk of falling. Assistive devices like rollators help to reduce that risk, especially by compensating for decreased leg muscle strength and balance problems. Paradoxically, rollators have been found to be a fall risk as well as being difficult to use. To investigate the causes, this study examines how different levels of rollator support (no assistance, light touch, and full support) and balance demands (standard lab floor, balance pads) affect movement coordination during standing up and sitting down movements.
Methods
Twenty young participants stood up and sat down while full-body kinematics and muscle activity (30 channels) were recorded. Participants stood up and at down using different movement strategies (e.g., forward leaning, hybrid, and vertical rise standing up movement strategies). For each movement strategy, spatial and temporal muscle synergies were extracted from the muscle activity patterns. Temporal muscle synergies provided a more compact, low-dimensional representation than spatial muscle synergies, so they were subsequently clustered with k-means++. The activation duration of the temporal muscle synergies was assessed with full-width at half-maximum at the main peak. Multivariate linear mixed models were used to investigate if the muscle activation vectors associated with the temporal muscle synergies differed across the support conditions.
Results
The activation profiles of the temporal muscle synergy timing, but not the shape, differed across the movement strategies for both types of movement. Across all tasks, temporal muscle synergies showed a narrower width of activation around the time of seat-off and seat-on than at the movement start and end. No support-specific temporal muscle synergies were found, but lower-limb muscle activity decreased while upper-limb muscle activity increased with increased support.
Conclusion
The narrow shape of the temporal synergy activation profiles suggests that the central nervous system controls the movements tightly, especially around seat-off and seat-on and in challenging conditions with increased balance demands. Furthermore, rollator support increases upper-body and decreases lower-body muscle activity, especially around seat-off and seat-on. Future studies may further investigate how the loss of tight movement control may cause falls in older individuals.
Impact of the digital health application ViViRA on spinal mobility, physical function, quality of life and pain perception in patients with seronegative spondyloarthropathies: a randomized controlled trial
Authors: Blaskowitz Paloma Palm von Alten , Bouzas Claudia , Coppers Birte , Liphardt Anna-Maria , Petit Pascal , Vuillerme Nicolas , Bundle Vanessa , Rudolf Sebastian , Knitza Johannes , Raimondo Maria Gabriella , Labinsky Hannah , Hatscher Lukas , Wirsching Andreas , Bohr Daniela , Araujo Elizabeth , Ramming Andreas , Ramming Alina , Schett Georg , Morf Harriet 
Published: October 2024

Abstract

Background: Seronegative spondyloarthropathies (SpA) are a group of common rheumatic diseases that often cause limited mobility and lower back pain. Physiotherapy is an integral part of treatment, but access to physiotherapy limits treatment success. Digital health applications (DHAs) enable home-based physiotherapy and could significantly improve access for SpA patients. The aim is to investigate the clinical effects of the DHA ViViRA compared with those of standard physiotherapy.
Methods: SpA patients with persistent back pain were enrolled in a randomized controlled trial. The intervention group received ViVira DHA, whereas the control group received standard physiotherapy. Pain (verbal rating scale, PAIN-Detect), quality of life (SF-36) and mobility (BASMI) were assessed at baseline and after 12 weeks as the primary outcomes.
Results: Data from 59 participants (71.2% female, mean age 45.2 years) were analyzed. The intervention group showed a significant improvement in mobility (average BASMI score: baseline: 1.12 [range 0.7-1.5]; follow-up: 0.95 [range 0.5-1.4]; p=0.047), whereas the control group showed a significant decrease in mobility (baseline: 1.5 [range 1.1-1.9]; follow-up: 1.8 [range 1.4-2.2]; p=0.002). The intervention group demonstrated significantly lower pain intensity (VRS pain level at week 3.5 ± 2.8) than did the control group (VRS pain level at week 4.5 ± 2) after 12 weeks.
Conclusion: Our results highlight the efficacy of DHAs such as ViViRA in the treatment of lower back pain in SpA patients. Compared with the current gold standard, physiotherapy, DHA use results in superior outcomes. However, further larger studies are needed to confirm these promising results.
Trial Registration: The study is registered in the German clinical trial registry (DRKS) under the following ID: DRKS00031254