bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jealousy in adolescents' daily lives: How does it relate to interpersonal context and well‐being?
Authors: Lennarz Hannah K. , Lichtwarck‐Aschoff Anna , Finkenauer Catrin , Granic Isabela 
Published: November 2016

ABSTRACTPast studies have shown that jealousy peaks in adolescence. However, little is known about how and when adolescents experience jealousy in their daily lives. The current study aimed to examine the relation between state jealousy, the more general propensity to feel jealous, the interpersonal contexts in which jealousy arises, and different forms of social comparison. The impact of jealousy on perceptions of well‐being was also explored. We used an experience sampling method during two weekends with 68 adolescents (Mage = 13.94; 64.70% girls). Jealousy was common: On average, 90% of our sample experienced jealousy in 20% of the assessments. Adolescents reported more jealousy with peers than with family. Additionally, they experienced more jealousy when in online contexts than when in face‐to‐face peer contexts. The normative nature of jealousy, its developmental function and relation with well‐being, and implications for understanding jealousy triggered in (highly social) online contexts are discussed.
STELES AND STATUS: EVIDENCE FOR THE EMERGENCE OF A NEW ELITE IN YUAN NORTH CHINA
Authors: Iiyama Tomoyasu 
Published: November 2016

AbstractDrawing on stele inscriptions in a Yuan-period ancestral graveyard, this article aims to shed light on the emergence and evolution of a Chinese office-holding family in North China under Mongol rule (thirteenth- to fourteenth century). Tracing the family's connections with Mongols, it argues that adaptation to the Mongolian patronage system was essential to obtaining and maintaining political status during the Yuan, and that the kin group was stratified with the patronized descent line monopolizing political privilege. In doing so, the article highlights the value of stone inscriptions in clarifying official status, patronage, and inheritance rights in North China during the Yuan period.
THE HARMONIZATION OF THE AVOIDANCE RULES IN EUROPEAN UNION INSOLVENCIES
Authors: Keay Andrew 
Published: November 2016

AbstractCross-border transactions and resultant legal proceedings often cause problems. One major problem is knowing which law should govern the transaction and any legal proceedings. Cross-border insolvencies in the EU are subject to the European Regulation on Insolvency Proceedings (EIR) but this legislation does not determine which substantive insolvency law rules apply in a given insolvency. There are many differences in the insolvency rules applicable in the various EU Member States and this has caused concern in relation to the avoidance of transactions entered into by an insolvent prior to the opening of insolvency proceedings. In light of this, the paper examines options to address divergence between national avoidance rules. One option, harmonization, is analysed as well as its possible benefits and drawbacks.
Morphological awareness as a function of semantics, phonology, and orthography and as a predictor of reading comprehension in Chinese
Authors: LI HONG , DRONJIC VEDRAN , CHEN XI , LI YIXUN , CHENG YAHUA , WU XINCHUN 
Published: November 2016

AbstractThis study investigates the contributions of semantic, phonological, and orthographic factors to morphological awareness of 413 Chinese-speaking students in Grades 2, 4, and 6, and its relationship with reading comprehension. Participants were orally presented with pairs of bimorphemic compounds and asked to judge whether the first morphemes of the words shared a meaning. Morpheme identity (same or different), whole-word semantic relatedness (high or low), orthography (same or different), and phonology (same or different) were manipulated. By Grade 6, children were able to focus on meaning similarities across morphemes while ignoring the distraction of form, but they remained influenced by whole-word semantic relatedness. Children's ability to overcome the distraction of phonology consistently improved with age, but did not reach ceiling, whereas the parallel ability for orthography reached ceiling at Grade 6. Morphological judgment performance was a significant unique predictor of reading comprehension when character naming and vocabulary knowledge were accounted for.
THE PLACE OF FORCE IN GENERAL JURISPRUDENCE
Authors: Pojanowski Jeffrey A. 
Published: November 2016

ABSTRACTThis essay reviews Frederick Schauer's book, The Force of Law (2015). Schauer argues that coercion is central to legal practice and should be no less important in legal theory. In doing so, Schauer presents formidable challenges to standard versions of legal positivism—and does so from within the positivist framework. Much of Schauer's criticism on that score is sound. His analysis of the role coercion can play in accomplishing law's moral tasks is also welcome and important. Nevertheless, Schauer's jurisprudential framework comes up short in its inability to distinguish law from other social practices that also use force. The Force of Law’s strong critique of contemporary positivism and the incompleteness of its own method make an indirect case for the classical tradition of theorizing that understands law in light of its moral purposes.
Fast ensemble representations for abstract visual impressions
Authors: Leib Allison Yamanashi , Kosovicheva Anna , Whitney David 
Published: November 2016

AbstractMuch of the richness of perception is conveyed by implicit, rather than image or feature-level, information. The perception of animacy or lifelikeness of objects, for example, cannot be predicted from image level properties alone. Instead, perceiving lifelikeness seems to be an inferential process and one might expect it to be cognitively demanding and serial rather than fast and automatic. If perceptual mechanisms exist to represent lifelikeness, then observers should be able to perceive this information quickly and reliably, and should be able to perceive the lifelikeness of crowds of objects. Here, we report that observers are highly sensitive to the lifelikeness of random objects and even groups of objects. Observers’ percepts of crowd lifelikeness are well predicted by independent observers’ lifelikeness judgements of the individual objects comprising that crowd. We demonstrate that visual impressions of abstract dimensions can be achieved with summary statistical representations, which underlie our rich perceptual experience.
Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions
Authors: Manzi Lucio , Barrow Andrew S. , Scott Daniel , Layfield Robert , Wright Timothy G. , Moses John E. , Oldham Neil J. 
Published: November 2016

AbstractSpecific interactions between proteins and their binding partners are fundamental to life processes. The ability to detect protein complexes, and map their sites of binding, is crucial to understanding basic biology at the molecular level. Methods that employ sensitive analytical techniques such as mass spectrometry have the potential to provide valuable insights with very little material and on short time scales. Here we present a differential protein footprinting technique employing an efficient photo-activated probe for use with mass spectrometry. Using this methodology the location of a carbohydrate substrate was accurately mapped to the binding cleft of lysozyme, and in a more complex example, the interactions between a 100 kDa, multi-domain deubiquitinating enzyme, USP5 and a diubiquitin substrate were located to different functional domains. The much improved properties of this probe make carbene footprinting a viable method for rapid and accurate identification of protein binding sites utilizing benign, near-UV photoactivation.
Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases
Authors: Padovani Dominique , Hessani Assia , Castillo Francine T. , Liot Géraldine , Andriamihaja Mireille , Lan Annaïg , Pilati Camilla , Blachier François , Sen Suvajit , Galardon Erwan , Artaud Isabelle 
Published: November 2016

AbstractAccumulating evidence suggests that abnormal levels of homocysteine are associated with vascular dysfunctions, cancer cell proliferation and various neurodegenerative diseases. With respect to the latter, a perturbation of transition metal homeostasis and an inhibition of catalase bioactivity have been reported. Herein, we report on some of the molecular bases for the cellular toxicity of homocysteine and demonstrate that it induces the formation of sulfcatalase, an irreversible inactive state of the enzyme, without the intervention of hydrogen sulfide. Initially, homocysteine reacts with native catalase and/or redox-active transition metal ions to generate thiyl radicals that mediate compound II formation, a temporarily inactive state of the enzyme. Then, the ferryl centre of compound II intervenes into the unprecedented S-oxygenation of homocysteine to engender the corresponding sulfenic acid species that further participates into the prosthetic heme modification through the formation of an unusual Fe(II) sulfonium. In addition, our ex cellulo studies performed on cancer cells, models of neurodegenerative diseases and ulcerative colitis suggest the likelihood of this scenario in a subset of cancer cells, as well as in a cellular model of Parkinson’s disease. Our findings expand the repertoire of heme modifications promoted by biological compounds and point out another deleterious trait of disturbed homocysteine levels that could participate in the aetiology of these diseases.
In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development
Authors: Ozerov Ivan V. , Lezhnina Ksenia V. , Izumchenko Evgeny , Artemov Artem V. , Medintsev Sergey , Vanhaelen Quentin , Aliper Alexander , Vijg Jan , Osipov Andreyan N. , Labat Ivan , West Michael D. , Buzdin Anton , Cantor Charles R. , Nikolsky Yuri , Borisov Nikolay , Irincheeva Irina , Khokhlovich Edward , Sidransky David , Camargo Miguel Luiz , Zhavoronkov Alex 
Published: November 2016

AbstractSignalling pathway activation analysis is a powerful approach for extracting biologically relevant features from large-scale transcriptomic and proteomic data. However, modern pathway-based methods often fail to provide stable pathway signatures of a specific phenotype or reliable disease biomarkers. In the present study, we introduce the in silico Pathway Activation Network Decomposition Analysis (iPANDA) as a scalable robust method for biomarker identification using gene expression data. The iPANDA method combines precalculated gene coexpression data with gene importance factors based on the degree of differential gene expression and pathway topology decomposition for obtaining pathway activation scores. Using Microarray Analysis Quality Control (MAQC) data sets and pretreatment data on Taxol-based neoadjuvant breast cancer therapy from multiple sources, we demonstrate that iPANDA provides significant noise reduction in transcriptomic data and identifies highly robust sets of biologically relevant pathway signatures. We successfully apply iPANDA for stratifying breast cancer patients according to their sensitivity to neoadjuvant therapy.
Mechanical gating of a mechanochemical reaction cascade
Authors: Wang Junpeng , Kouznetsova Tatiana B. , Boulatov Roman , Craig Stephen L. 
Published: November 2016

AbstractCovalent polymer mechanochemistry offers promising opportunities for the control and engineering of reactivity. To date, covalent mechanochemistry has largely been limited to individual reactions, but it also presents potential for intricate reaction systems and feedback loops. Here we report a molecular architecture, in which a cyclobutane mechanophore functions as a gate to regulate the activation of a second mechanophore, dichlorocyclopropane, resulting in a mechanochemical cascade reaction. Single-molecule force spectroscopy, pulsed ultrasonication experiments and DFT-level calculations support gating and indicate that extra force of >0.5 nN needs to be applied to a polymer of gated gDCC than of free gDCC for the mechanochemical isomerization gDCC to proceed at equal rate. The gating concept provides a mechanism by which to regulate stress-responsive behaviours, such as load-strengthening and mechanochromism, in future materials designs.
Deconvoluting complex structural histories archived in brittle fault zones
Authors: Viola G. , Scheiber T. , Fredin O. , Zwingmann H. , Margreth A. , Knies J. 
Published: November 2016

AbstractBrittle deformation can saturate the Earth’s crust with faults and fractures in an apparently chaotic fashion. The details of brittle deformational histories and implications on, for example, seismotectonics and landscape, can thus be difficult to untangle. Fortunately, brittle faults archive subtle details of the stress and physical/chemical conditions at the time of initial strain localization and eventual subsequent slip(s). Hence, reading those archives offers the possibility to deconvolute protracted brittle deformation. Here we report K-Ar isotopic dating of synkinematic/authigenic illite coupled with structural analysis to illustrate an innovative approach to the high-resolution deconvolution of brittle faulting and fluid-driven alteration of a reactivated fault in western Norway. Permian extension preceded coaxial reactivation in the Jurassic and Early Cretaceous fluid-related alteration with pervasive clay authigenesis. This approach represents important progress towards time-constrained structural models, where illite characterization and K-Ar analysis are a fundamental tool to date faulting and alteration in crystalline rocks.
Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells
Authors: Brandalise Federico , Carta Stefano , Helmchen Fritjof , Lisman John , Gerber Urs 
Published: November 2016

AbstractThe computational repertoire of neurons is enhanced by regenerative electrical signals initiated in dendrites. These events, referred to as dendritic spikes, can act as cell-intrinsic amplifiers of synaptic input. Among these signals, dendritic NMDA spikes are of interest in light of their correlation with synaptic LTP induction. Because it is not possible to block NMDA spikes pharmacologically while maintaining NMDA receptors available to initiate synaptic plasticity, it remains unclear whether NMDA spikes alone can trigger LTP. Here we use dendritic recordings and calcium imaging to analyse the role of NMDA spikes in associative LTP in CA3 pyramidal cells. We show that NMDA spikes produce regenerative branch-specific calcium transients. Decreasing the probability of NMDA spikes reduces LTP, whereas increasing their probability enhances LTP. NMDA spikes and LTP occur without back-propagating action potentials. However, action potentials can facilitate LTP induction by promoting NMDA spikes. Thus, NMDA spikes are necessary and sufficient to produce the critical postsynaptic depolarization required for associative LTP in CA3 pyramidal cells.
Contributions of distinct gold species to catalytic reactivity for carbon monoxide oxidation
Authors: Guo Li-Wen , Du Pei-Pei , Fu Xin-Pu , Ma Chao , Zeng Jie , Si Rui , Huang Yu-Ying , Jia Chun-Jiang , Zhang Ya-Wen , Yan Chun-Hua 
Published: November 2016

AbstractSmall-size (<5 nm) gold nanostructures supported on reducible metal oxides have been widely investigated because of the unique catalytic properties they exhibit in diverse redox reactions. However, arguments about the nature of the gold active site have continued for two decades, due to the lack of comparable catalyst systems with specific gold species, as well as the scarcity of direct experimental evidence for the reaction mechanism under realistic working conditions. Here we report the determination of the contribution of single atoms, clusters and particles to the oxidation of carbon monoxide at room temperature, by the aid of in situ X-ray absorption fine structure analysis and in situ diffuse reflectance infrared Fourier transform spectroscopy. We find that the metallic gold component in clusters or particles plays a much more critical role as the active site than the cationic single-atom gold species for the room-temperature carbon monoxide oxidation reaction.
Polarization curling and flux closures in multiferroic tunnel junctions
Authors: Peters Jonathan J. P. , Apachitei Geanina , Beanland Richard , Alexe Marin , Sanchez Ana M. 
Published: November 2016

AbstractFormation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields are deliberately maximized, that is, in films between insulating layers. As such configurations are devoid of screening charges provided by metal electrodes, commonly used in electronic devices, it is wise to investigate if curling polarization structures are innate to ferroelectricity or induced by the absence of electrodes. Here we show that in unpoled Co/PbTiO3/(La,Sr)MnO3 ferroelectric tunnel junctions, the polarization in active PbTiO3 layers 9 unit cells thick forms Kittel-like domains, while at 6 unit cells there is a complex flux-closure curling behaviour resembling an incommensurate phase. Reducing the thickness to 3 unit cells, there is an almost complete loss of switchable polarization associated with an internal gradient.
Epigenetic and genetic components of height regulation
Authors: Benonisdottir Stefania , Oddsson Asmundur , Helgason Agnar , Kristjansson Ragnar P. , Sveinbjornsson Gardar , Oskarsdottir Arna , Thorleifsson Gudmar , Davidsson Olafur B. , Arnadottir Gudny A. , Sulem Gerald , Jensson Brynjar O. , Holm Hilma , Alexandersson Kristjan F. , Tryggvadottir Laufey , Walters G. Bragi , Gudjonsson Sigurjon A. , Ward Lucas D. , Sigurdsson Jon K. , Iordache Paul D. , Frigge Michael L. , Rafnar Thorunn , Kong Augustine , Masson Gisli , Helgason Hannes , Thorsteinsdottir Unnur , Gudbjartsson Daniel F. , Sulem Patrick , Stefansson Kari 
Published: November 2016

AbstractAdult height is a highly heritable trait. Here we identified 31.6 million sequence variants by whole-genome sequencing of 8,453 Icelanders and tested them for association with adult height by imputing them into 88,835 Icelanders. Here we discovered 13 novel height associations by testing four different models including parent-of-origin (|β|=0.4–10.6 cm). The minor alleles of three parent-of-origin signals associate with less height only when inherited from the father and are located within imprinted regions (IGF2-H19 and DLK1-MEG3). We also examined the association of these sequence variants in a set of 12,645 Icelanders with birth length measurements. Two of the novel variants, (IGF2-H19 and TET1), show significant association with both adult height and birth length, indicating a role in early growth regulation. Among the parent-of-origin signals, we observed opposing parental effects raising questions about underlying mechanisms. These findings demonstrate that common variations affect human growth by parental imprinting.
Magnetofermionic condensate in two dimensions
Authors: Kulik L. V. , Zhuravlev A. S. , Dickmann S. , Gorbunov A. V. , Timofeev V. B. , Kukushkin I. V. , Schmult S. 
Published: November 2016

AbstractCoherent condensate states of particles obeying either Bose or Fermi statistics are in the focus of interest in modern physics. Here we report on condensation of collective excitations with Bose statistics, cyclotron magnetoexcitons, in a high-mobility two-dimensional electron system in a magnetic field. At low temperatures, the dense non-equilibrium ensemble of long-lived triplet magnetoexcitons exhibits both a drastic reduction in the viscosity and a steep enhancement in the response to the external electromagnetic field. The observed effects are related to formation of a super-absorbing state interacting coherently with the electromagnetic field. Simultaneously, the electrons below the Fermi level form a super-emitting state. The effects are explicable from the viewpoint of a coherent condensate phase in a non-equilibrium system of two-dimensional fermions with a fully quantized energy spectrum. The condensation occurs in the space of vectors of magnetic translations, a property providing a completely new landscape for future physical investigations.
Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
Authors: Damiani Devid , Goffinet André M. , Alberts Arthur , Tissir Fadel 
Published: November 2016

AbstractThe diaphanous homologue Diaph3 (aka mDia2) is a major regulator of actin cytoskeleton. Loss of Diaph3 has been constantly associated with cytokinesis failure ascribed to impaired accumulation of actin in the cleavage furrow. Here we report that Diaph3 is required before cell fission, to ensure the accurate segregation of chromosomes. Inactivation of the Diaph3 gene causes a massive loss of cortical progenitor cells, with subsequent depletion of intermediate progenitors and neurons, and results in microcephaly. In embryonic brain extracts, Diaph3 co-immunoprecipitates with BubR1, a key regulator of the spindle assembly checkpoint (SAC). Diaph3-deficient cortical progenitors have decreased levels of BubR1 and fail to properly activate the SAC. Hence, they bypass mitotic arrest and embark on anaphase in spite of incorrect chromosome segregation, generating aneuploidy. Our data identify Diaph3 as a major guard of cortical progenitors, unravel novel functions of Diaphanous formins and add insights into the pathobiology of microcephaly.
The threshold effects of meteorological factors on Hand, foot, and mouth disease (HFMD) in China, 2011
Authors: Du Zhicheng , Zhang Wangjian , Zhang Dingmei , Yu Shicheng , Hao Yuantao 
Published: November 2016

AbstractWe explored the threshold effects of meteorological factors on hand, foot and mouth disease (HFMD) in mainland China to improve the prevention and early warning. Using HFMD surveillance and meteorological data in 2011, we identified the threshold effects of predictors on the monthly incidence of HFMD and predicted the high risk months, with classification and regression tree models (CART). The results of the classification tree showed that there was an 82.35% chance for a high risk of HFMD when the temperature was greater than 24.03 °C and the relative humidity was less than 60.9% during non-autumn seasons. According to the heatmap of high risk prediction, the HFMD incidence in most provinces was beyond the normal level during May to August. The results of regression tree showed that when the temperature was greater than 24.85 °C and the relative humidity was between 80.59% and 82.55%, the relative risk (RR) of HFMD was 3.49 relative to monthly average incidence. This study provided quantitative evidence for the threshold effects of meteorological factors on HFMD in China. The conditions of a temperature greater than 24.85 °C and a relative humidity between 80.59% and 82.55% would lead to a higher risk of HFMD.