bluuebunny/crossref_metadata_2025_split huggingface dataset:
دورالتخطـيط الضريبي لكبارالمكلفين في زيادةالايرادات الضريبية
Authors: حسن سالم محسن  , ميسون عبد الكريم احمد  
Published: October 2024

تأتي اهمية البحث من اهمية السياسة الضريبية وهي احدى الادوات التي تعمل على تحقيق الاهداف الاقتصادية والمالية والاجتماعية وتحسين البيئة الاستثمـارية للبلاد ليصبح اكثر قدرة على تنشيطـ عجلة الاقتصاد الوطـني انطـلق البحث من مشكلة هي (هل التخطـيطـ الضريبي الذي يمارسه كبار المكلفين يؤثر في الوعاء الضريبي على المدى البعيد من خلال الاستفادة من الوفورات النقدية والتوسع بالنشاطـات المختلفة اوانشاء مشاريع جديدة مما ينعكس على الوعاء الضريبي وبالتالي زيادة الايرادات الضريبية) بينما فرضية البحث نصت على ان التخطـيطـ الضريبي الذي يمارسه كبار المكلفين يسهم في التشجيع بالدخول في مشاريع جديدة تتناسب تناسباً طـرديا مع الايرادات الضريبية في المدىالطـويل ويهدف البحث الى توضيح مفهوم التخطـيطـ الضريبي واهميته واستراتيجياته ومدى مساهمته في رسم سياسات التوسع بالاستثمـار، واسفر البحث عن جملة من الاستنتاجات ابرزها ان كبار المكلفين عينة البحث قد اتفقوا على ان الوفورات الضريبية التي يتم الحصول عليها من خلال التخطـيطـ الضريبي تعد عاملاً رئيسي في تحديد المركز الاقتصادي للدولة في المدى القصير والسبب الرئيسي للنمو الاقتصادي في المدى البعيد وهوالسبب في خلق فرص عمل جديدة وضخ الانتاج والخدمات ونقل التكنلوجيا وزيادة الصادرات وبالنتيجة ينعكس ذلك ايجابياً في مساهمة هذه الشركات في نمو الاقتصاد وزيادة الايرادات الضريبية في المستقبل، ومن اهم التوصيات في البحث هي على كبار المكلفين ابداء المزيد من الاهتمام بعملية التخطـيطـ الضريبي لغرض تخفيض الالتزامات الضريبية دون ان يكون هناك تعارض مع القانون وتحقيق المزيد من الارباح والوفورات النقدية واستخدامها في مجالات التوسع بنشاطـاتها وفتح شركات متخصصة او فروع داخل او خارج البلد وضمان استمرار عملها.
DESEMPENHO DE CULTIVARES DE FEIJÃO-CAUPI SOB APLICAÇÃO FOLIAR DE SILÍCIO NO CERRADO PIAUIENSE
Authors: Dos Santos Graziela Pereira , Avelino Gabriella Guedes , Silva Fabiano de Oliveira , Leite Wallace de Sousa 
Published: October 2024

As plantas estão sujeitas a estresses abióticos a qualquer momento, e estes afetam negativamente o crescimento e a produção de espécies de interesse agronômico, como o feijão-caupi. Neste contexto, o Silício (Si) surge como uma alternativa estratégica de manejo visando melhorar o desempenho das plantas em condições adequadas de cultivo, e principalmente, sob condições com restrições, devido a sua atuação potencializadora no desenvolvimento das plantas. No entanto, estudos em campo sob sequeiro que englobem elementos minerais benéficos no feijão-caupi ainda são incipientes. Nesse sentido, o objetivo do estudo foi avaliar a ação de diferentes doses de silício nos parâmetros de crescimento e produtividade de grãos de duas cultivares do feijão-caupi. O estudo foi conduzido em campo sob condições de sequeiro, na Fazenda Experimental do IFPI- campus Uruçuí, no delineamento experimental de blocos ao acaso com quatro repetições, em esquema de parcelas subsubdivididas 2 x 4, as parcelas correspondendo as duas cultivares de feijão-caupi (BRS Novaera e BRS Tumucumaque) e as subparcelas constituídas por quatro doses de Si (0, 5, 10, 20 g ha-1). Foram avaliados os seguintes caracteres: altura da planta, massa seca da parte aérea, número de vagens por planta, número de grãos por vagem, massa de 100 grãos e a produtividade média de grãos. A aplicação de silício influenciou positivamente a altura de plantas e a produtividade média das cultivares. A cultivar BRS Tumucumaque apresentou um incremento de 59,97% na produtividade de grãos quando o Si foi fornecido na dose de 10 g ha-1, e a BRS Novaera teve um melhor comportamento quanto a produtividade de grãos na dose de 20 g ha-1, com incremento de 46,93%. Conclui-se que a suplementação com silício é uma estratégia promissora para melhorar o desempenho agronômico do feijão-caupi.
SILAGEM DE SORGO CULTIVAR IG100 E XS9454 APÓS A COLHEITA DO GRÃO: PERFIL FERMENTATIVO E ESTABILIDADE AERÓBICA
Authors: Da Silva Welder Willian Angêlo , Júlio Silva Arthur Lucas , De Lira dos Santos Keyla Laura 
Published: October 2024

Avaliou-se as características fermentativas e a estabilidade aeróbica da silagem de sorgo granífero após a colheita dos grãos. A pesquisa foi desenvolvida na Universidade Federal Rural de Pernambuco – Unidade Acadêmica de Serra Talhada (UFRPE-UAST), sendo o sorgo plantado na área da Empresa Pernambucana de Pesquisa – IPA. O delineamento experimental foi inteiramente casualizado, com três tratamentos, sorgo 1G100 adubado com NPK, 1G100 sem adubo e XS9454 com adubo NPK e três repetições. Para a produção da silagem foram utilizadas mini silos experimentais de cano de PVC 0,10 x 0,50 cm e sacolas de 20 L. Após 35 dias, os silos foram abertos e realizadas as seguintes análises: sensoriais (cor, odor e textura); MS, pH, perdas fermentativas e estabilidade aeróbica e submetidos à análise de variância e teste de média. As características sensoriais foram realizadas no momento da abertura dos silos, sendo a cor, odor e textura de todas as silagens caracterizadas entre boa e média. Houve efeito (P<0,05) para o teor de MS e pH da silagem. A perda de gases e MS não diferiram (P>0,05) e foram consideradas adequadas ao padrão processo fermentativo. Após período de 240h (10 dias) de exposição ao ar os valores de pH entre as silagens não se diferiram (P>0,05), apresentando valores de 4,51, 4,40, 4,36 para 1G100 s/adubo, 1G100 c/adubo e XS9454/adubo, respectivamente, porém já era possível visualizar o crescimento de fungos. Conclui-se que as silagens foram classificadas como de boa a média qualidade em termos de teor de matéria seca, características sensoriais e fermentação. Nenhuma das silagens apresentou deterioração completa durante o período de estabilidade aeróbica de 240 horas observadas, mantendo-se, grandes partes estáveis ao longo desse período, o que permite melhor utilização da silagem.
Testing the Efficiency of a Heat Pump with Radiant Systems in Heating Mode
Authors: Šimko Martin , Petráš Dušan , Szabó Daniel , Živner Lukáš , Takács Ján 
Published: October 2024

The paper deals with the experimental testing of the efficiency of the operation of an air/water heat pump in connection with three radiant systems in heating mode in an office building, which is part of the central laboratories of the Slovak university of Technology in Bratislava. The testing was aimed at verifying the manufacturer's theoretical claims about efficiency of the heat pump based on the COP and SCOP values according to EN 14511-1:2022 and EN 14825:2022. The testing period was from 7 Jan. 2024 until 15 Jan. 2024. The aim of the testing measurements was to evaluate the calculated value of SPF efficiency for individual days and for the testing period. During the measuring period, the wall radiant system consumed 188 kWh, the ceiling system 216 kWh, and the floor radiant system 196 kWh. The heat pump consumed 227 kWh of electricity. The calculated SPF value was 2.64.
Стимулювання інноваційної діяльності підприємства: фінансовий, логістичний та цифровий аспекти
Authors: Птащенко О.В. 
Published: October 2024

В представленій роботі акцентовано увагу на тому що у сучасному бізнес-середовищі інноваційна діяльність є основою для досягнення конкурентних переваг і забезпечення сталого розвитку підприємств. В умовах швидко змінюваного ринкового середовища і технологічних революцій, підприємства повинні постійно адаптуватися і вдосконалювати свої продукти, послуги та бізнес-процеси. Стимулювання інноваційної діяльності є критично важливим фактором, який впливає на здатність компаній залишатися на передовій лінії розвитку і забезпечувати високі результати. Метою представленої роботи є визначення основних стимулів інноваційної діяльності підприємства, а також аналіз фінансового логістичного та цифрового аспектів впливу на інноваційну діяльність сучасного підприємства. Основними методами представленої роботи є: методи аналізу та синтезу, логічний метод, метод узагальнення, метод систематизації, табличний метод, графічний метод, методи індукції та дедукції. Представлені методи дозволяють обґрунтовано провести аналіз представленої проблематики та визначити основні завдання поточного дослідження. Так основні аспекти впливу на стимулювання інноваційної діяльності підприємства представлені як: фінансовий, цифровий та логістичний. Фінансовий аспект інноваційної діяльності передбачає забезпечення достатніх ресурсів для реалізації нових ідей і проектів. Інвестиції в інновації часто вимагають значних витрат, тому ефективне фінансування стає ключовим чинником успіху. Це може включати не лише власні ресурси компанії, але й залучення зовнішнього капіталу через венчурний капітал, гранти або кредитування. Логістичний аспект охоплює управління ресурсами і процесами, необхідними для впровадження інновацій. Це включає організацію виробництва, постачання матеріалів, управління ланцюгами постачання та оптимізацію внутрішніх процесів. Ефективна логістика забезпечує безперебійний потік ресурсів і знижує витрати, що є важливим для швидкого і успішного виведення нових продуктів на ринок. Цифровий аспект стимулювання інновацій охоплює використання сучасних технологій і цифрових інструментів для підтримки і розвитку інноваційних процесів. Це включає впровадження цифрових платформ, аналітики даних, штучного інтелекту та інших технологій, що дозволяють не лише автоматизувати бізнес-процеси, але й створювати нові продукти та послуги, які відповідають потребам ринку. Таким чином, стимулювання інноваційної діяльності підприємства вимагає комплексного підходу, що охоплює фінансові, логістичні та цифрові аспекти. Збалансоване управління цими компонентами дозволяє підприємствам ефективно реалізовувати свої інноваційні стратегії, забезпечувати конкурентоспроможність і досягати успіху в умовах сучасного ринку.
Identification and Growth Characteristics of Cellulase Producing Bacteria
Authors: Wang Qingrong , Wu Chao , Lv Jixia 
Published: October 2024

This study was envisaged to from fresh cow dung using the Congo red staining method, and screened by measuring their endoglucanase activity (CMC enzyme activity), exoglucanase activity (Cex enzyme activity), and filter paper enzyme activity (FPA enzyme activity). Subsequently, the molecular, morphological characteristics, and growth characteristics were studied. Three strains showed clear transparent circles on the Congo red cellulose medium. LY3 exhibited strong enzyme production ability, with relatively higher enzyme activity than the other two strains. LY3 was found to be a dominant strain that required a temperature of 40℃and pH 7.0 for optimal growth. Based on the molecular and morphological characteristics, the three strains were preliminarily identified as Bacillus.
Bangladesh J. Bot. 53(3): 849-856, 2024 (September) Special
Evaluation of STK17B as a cancer immunotherapy target utilizing highly potent and selective small molecule inhibitors
Authors: Scheuplein Felix , Renner Florian , Campbell John E. , Campbell Robert , De Savi Chris , Eckmann Jan , Fischer Holger , Ge Jie , Green Luke , Jakob Peter , Kim Joseph L. , Kinkema Caitlin , McGinn Katie , Medina Ricardo , Müller Annemarie , Perez Nisha , Perola Emanuele , Timsit Yoav , Traore Tary , Hopfer Ulrike , Tyanova Stefka , Tzouros Manuel , Wang Ruduan , Woessner Richard , Dorsch Marion , Bischoff James R. 
Published: October 2024

IntroductionThe serine/threonine kinase 17B (STK17B) is involved in setting the threshold for T cell activation and its absence sensitizes T cells to suboptimal stimuli. Consequently, STK17B represents an attractive potential target for cancer immunotherapy.MethodsTo assess the potential of STK17B as an immuno-oncology target, we developed potent and selective tool compounds from starting points in Blueprint Medicines Corporation's proprietary kinase inhibitor library. To characterize these molecules, enzyme and cellular assays for STK17A and STK17B were established to drive chemistry optimization. Mass spectrometry-based phosphoproteomics profiling with tool inhibitors led to the identification of Ser19 on myosin light chain 2 as STK17B substrate, which is then developed into a flow cytometry-based pharmacodynamic readout of STK17B inhibition both in vitro and in vivo.ResultsIn a mouse T cell activation assay, STK17B inhibitors demonstrated the ability to enhance interleukin-2 (IL-2) production. Similarly, treatment with STK17B inhibitors resulted in stronger cytokine secretion in human T cells activated using a T cell bispecific antibody. Subsequent chemistry optimization led to the identification of a highly selective and orally bioavailable tool compound, BLU7482. In vivo, STK17B inhibition led to dose-dependent modulation of myosin light chain 2 phosphorylation and enhanced priming of naïve T cells, as determined by upregulation of CD69, IL-2 and interferon-γ secretion. In line with increased T cell activation, treatment with STK17B inhibitor enhanced antitumor activity of anti–PD-L1 antibody in the MCA205 model.ConclusionsIn summary, we successfully identified and optimized STK17B kinase inhibitors which led to increased T cell responses in vitro and in vivo. This allowed us to evaluate the potential of STK17B inhibition as an approach for cancer immunotherapy.
Incidence rate of hemorrhagic fever with renal syndrome complicated with acute pancreatitis: a meta-analysis
Authors: Ye Zhenzhen , Liu Xiaoqing , Ding Sheng , Lu Ling , Zhang Tianchen , Zhou Wenfang , Dong Yonghai 
Published: October 2024

BackgroundAcute pancreatitis (AP) is a rare but serious complication in patients diagnosed with hemorrhagic fever with renal syndrome (HFRS). When AP complicates HFRS, the clinical outcome significantly worsens and the risk of mortality increases. However, the incidence of AP in HFRS patients and its associated mortality risk remain unclear. To address this knowledge gap, we conducted a meta-analysis to determine the AP incidence rate in HFRS patients and assess the impact of AP on mortality in these patients.MethodsWe systematically searched seven databases (PubMed, Web of Science, EMBase, Sinomed, Chinese National Knowledge Infrastructure, WanFang Data, and Chongqing VIP) for relevant studies on HFRS complicated by AP. The studies were selected using predefined inclusion and exclusion criteria based on the Population, Intervention, Comparison, Outcome, and Study design principle. Two independent reviewers screened the studies, and the quality of the included studies was assessed using the Agency for Healthcare Research and Quality and the Newcastle-Ottawa Evaluation Scale (NOS).ResultsIn total, 11 studies, encompassing 1,218 HFRS patients, met the inclusion criteria. The overall incidence of HFRS complicated by AP was 8.5% (95% CI for r 5.9–11.1%). The HFRS patients with AP had a significantly higher risk of mortality than those without AP (OR = 3.668, 95% CI for OR 1.112–12.031). No statistically significant differences were observed in the subgroup and meta-regression analyses.ConclusionAlthough the incidence of AP in HFRS patients is not high, it significantly increases the risk of mortality in these patients. Future large-scale prospective studies are required to further validate these findings.
Role of artificial intelligence in staging and assessing of treatment response in MASH patients
Authors: Akpinar Reha , Panzeri Davide , De Carlo Camilla , Belsito Vincenzo , Durante Barbara , Chirico Giuseppe , Lombardi Rosa , Fracanzani Anna Ludovica , Maggioni Marco , Arcari Ivan , Roncalli Massimo , Terracciano Luigi M. , Inverso Donato , Aghemo Alessio , Pugliese Nicola , Sironi Laura , Di Tommaso Luca 
Published: October 2024

Background and AimsThe risk of disease progression in MASH increases proportionally to the pathological stage of fibrosis. This latter is evaluated through a semi-quantitative process, which has limited sensitivity in reflecting changes in disease or response to treatment. This study aims to test the clinical impact of Artificial Intelligence (AI) in characterizing liver fibrosis in MASH patients.MethodsThe study included 60 patients with clinical pathological diagnosis of MASH. Among these, 17 received a medical treatment and underwent a post-treatment biopsy. For each biopsy (n = 77) a Sirius Red digital slide (SR-WSI) was obtained. AI extracts &gt;30 features from SR-WSI, including estimated collagen area (ECA) and entropy of collagen (EnC).ResultsAI highlighted that different histopathological stages are associated with progressive and significant increase of ECA (F2: 2.6% ± 0.4; F3: 5.7% ± 0.4; F4: 10.9% ± 0.8; p: 0.0001) and EnC (F2: 0.96 ± 0.05; F3: 1.24 ± 0.06; F4: 1.80 ± 0.11, p: 0.0001); disclosed the heterogeneity of fibrosis among pathological homogenous cases; revealed post treatment fibrosis modification in 76% of the cases (vs 56% detected by histopathology).ConclusionAI characterizes the fibrosis process by its true, continuous, and non-categorical nature, thus allowing for better identification of the response to anti-MASH treatment.
Multi-stage semi-supervised learning enhances white matter hyperintensity segmentation
Authors: Duarte Kauê T. N. , Sidhu Abhijot S. , Barros Murilo C. , Gobbi David G. , McCreary Cheryl R. , Saad Feryal , Camicioli Richard , Smith Eric E. , Bento Mariana P. , Frayne Richard 
Published: October 2024

IntroductionWhite matter hyperintensities (WMHs) are frequently observed on magnetic resonance (MR) images in older adults, commonly appearing as areas of high signal intensity on fluid-attenuated inversion recovery (FLAIR) MR scans. Elevated WMH volumes are associated with a greater risk of dementia and stroke, even after accounting for vascular risk factors. Manual segmentation, while considered the ground truth, is both labor-intensive and time-consuming, limiting the generation of annotated WMH datasets. Un-annotated data are relatively available; however, the requirement of annotated data poses a challenge for developing supervised machine learning models.MethodsTo address this challenge, we implemented a multi-stage semi-supervised learning (M3SL) approach that first uses un-annotated data segmented by traditional processing methods (“bronze” and “silver” quality data) and then uses a smaller number of “gold”-standard annotations for model refinement. The M3SL approach enabled fine-tuning of the model weights with the gold-standard annotations. This approach was integrated into the training of a U-Net model for WMH segmentation. We used data from three scanner vendors (over more than five scanners) and from both cognitively normal (CN) adult and patients cohorts [with mild cognitive impairment and Alzheimer's disease (AD)].ResultsAn analysis of WMH segmentation performance across both scanner and clinical stage (CN, MCI, AD) factors was conducted. We compared our results to both conventional and transfer-learning deep learning methods and observed better generalization with M3SL across different datasets. We evaluated several metrics (F-measure, IoU, and Hausdorff distance) and found significant improvements with our method compared to conventional (p &lt; 0.001) and transfer-learning (p &lt; 0.001).DiscussionThese findings suggest that automated, non-machine learning, tools have a role in a multi-stage learning framework and can reduce the impact of limited annotated data and, thus, enhance model performance.
Can the radiomics features of intracranial aneurysms predict the prognosis of aneurysmal subarachnoid hemorrhage?
Authors: Huang Tianxing , Li Wenjie , Zhou Yu , Zhong Weijia , Zhou Zhiming 
Published: October 2024

ObjectivesThis study attempted to determine potential predictors among radiomics features for poor prognosis in aneurysmal subarachnoid hemorrhage (aSAH), develop models for prediction, and verify their predictive power.MethodsIn total, 252 patients with aSAH were included in this study and categorized into favorable and poor outcome groups based on the modified Rankin Scale score 3 months after event. Radiomics features of the ruptured intracranial aneurysm extracted from computed tomography angiography images were selected using least absolute shrinkage and selection operator regression and 10-fold cross-validation. A radiomics score was created by selecting the optimal features. Other risk factors for a poor prognosis were screened using multivariate regression analysis. Three models (clinical, aneurysm, and clinical-aneurysm combined models) were developed. The performance of the models was assessed using receiver operating characteristic (ROC) curves. A clinical-aneurysm combined nomogram was constructed to forecast the risk of poor prognosis in patients with aSAH.ResultsA total of three clinical variables and six radiomics features were shown to have a significant association with poor prognosis in patients with aSAH. In the training cohort, the clinical, aneurysm, and clinical-aneurysm combined models had areas under the ROC curves of 0.846, 0.762, and 0.893, respectively. In the testing cohort, these models had areas under the ROC curves of 0.848, 0.753, and 0.869, respectively.ConclusionThe radiomics characteristics of ruptured intracranial aneurysms are valuable to predict prognosis after aSAH. The clinical-aneurysm combined model exhibited the best among the three models. The clinical-aneurysm combined nomogram is a reliable and effective tool for predicting poor prognosis in patients with aSAH.
A rare case report of hemolysis in a newborn: hereditary elliptocytosis
Authors: Jiang Shouliang , Lu Ruifeng , Tang Jun 
Published: October 2024

IntroductionHereditary Elliptocytosis (HE) comprises clinically and genetically heterogeneous red cell membranopathies resulting from defects in the horizontal linkage between red blood cell (RBC) membrane and cytoskeletal proteins, which affect mechanical stability and deformability, thereby reducing RBC lifespan. The principal defect in HE is due to dysfunction or deficiency of RBC cytoskeletal proteins.Case descriptionThis study reported a case of severe hemolysis occurring within one day after birth in a term newborn. High-throughput sequencing was used to characterize the pathogenic gene variation in this child and to study the correlation between the identified variation and its corresponding phenotypic characteristics.ConclusionHE is caused by monoallelic mutations, which justify the phenotypic heterogeneity observed in patients. Furthermore, molecular analysis using high-throughput sequencing enables diagnosis in disorders with highly variable heterogeneity. HE can also present with severe hemolysis during the neonatal period.
Multifunctional nanomaterials composed entirely of active pharmaceutical ingredients for synergistically enhanced antitumor and antibacterial effects
Authors: An Qi , Wang Dongmei , Huang Liang , Chen Xiangyu , Wang Chuan 
Published: October 2024

IntroductionMultifunctional nanomaterials are emerging as promising tools for treating both cancer and bacterial infections. However, integrating dual therapeutic capabilities into a single system remains challenging. This study presents multifunctional nanoparticles (ECI-NPs) based on Epigallocatechin gallate (EGCG) oligomers, Curcumin (CUR), and Indocyanine Green (ICG) for combined cancer and bacterial treatment.MethodsECI-NPs were synthesized via oxidative coupling of EGCG, CUR, and ICG. The nanoparticles were characterized for stability, size, drug loading, and release profiles. Cellular uptake, phototoxicity in melanoma cells, and antibacterial activity against Escherichia coli and Staphylococcus aureus were also evaluated.ResultsECI-NPs demonstrated optimal stability, high drug loading, and controlled release. Cellular studies showed increased uptake and greater phototoxicity in melanoma cells compared to free drugs. ECI-NPs also exhibited enhanced anticancer effects and strong antibacterial activity, outperforming the individual components.DiscussionThe polyphenol-based ECI-NPs offer synergistic therapeutic effects, overcoming the limitations of free drugs in terms of solubility and efficacy. This dual-function platform shows potential for broader biomedical applications, addressing challenges in cancer and bacterial infections. Further research will focus on in vivo studies and clinical translation.