bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorescently Sensing of DNA Triplex Assembly Using an Isoquinoline Alkaloid as Selector, Stabilizer, Inducer, and Switch‐On Emitter
Authors: Hu Yuehua , Lin Fan , Wu Tao , Wang Ying , Zhou Xiao‐Shun , Shao Yong 
Published: June 2016

AbstractDNA triplex assembly has attracted a variety of interest in the regulation of genetic expression, drug screening, molecular switches, and sensors. However, these achievements are essentially dependent on the formation and stability of the triplex assembly. Herein, the recognition of DNA triplex assembly with various isoquinoline alkaloids was investigated. We found that natural chelerythrine (CHE) exhibits the highest selectivity in recognizing the triplex structure. The DNA triplex stability is substantially increased upon CHE binding, as opposed to the invariance in the stability of the duplex counterpart. CHE also favors the assembly of the triplex‐forming oligonucleotide (TFO) with its duplex counterpart. The triplex binding switches CHE to a strong fluorescent emitter, which suggests CHE as a useful probe in following triplex assembly. As a unique triplex selector, inducer, and emitter, CHE successfully reports the wide pH‐ and metal‐ion‐dependent tunability of the triplex nanoswitch in a label‐free manner.
Backfilling‐Free Strategy for Biopatterning on Intrinsically Dual‐Functionalized Poly[2‐Aminoethyl Methacrylate‐co‐Oligo(Ethylene Glycol) Methacrylate] Films
Authors: Lee Bong Soo , Lee Juno , Han Gyeongyeop , Ha EunRae , Choi Insung S. , Lee Jungkyu K. 
Published: June 2016

AbstractWe demonstrated protein and cellular patterning with a soft lithography technique using poly[2‐aminoethyl methacrylate‐co‐oligo(ethylene glycol) methacrylate] films on gold surfaces without employing a backfilling process. The backfilling process plays an important role in successfully generating biopatterns; however, it has potential disadvantages in several interesting research and technical applications. To overcome the issue, a copolymer system having highly reactive functional groups and bioinert properties was introduced through a surface‐initiated controlled radical polymerization with 2‐aminoethyl methacrylate hydrochloride (AMA) and oligo(ethylene glycol) methacrylate (OEGMA). The prepared poly(AMA‐co‐OEGMA) film was fully characterized, and among the films having different thicknesses, the 35 nm‐thick biotinylated, poly(AMA‐co‐OEGMA) film exhibited an optimum performance, such as the lowest nonspecific adsorption and the highest specific binding capability toward proteins.
Prognosis following surgical bypass compared with laparotomy alone in unresectable pancreatic adenocarcinoma
Authors: Insulander J , Sanjeevi S , Haghighi M , Ivanics T , Analatos A , Lundell L , Del Chiaro M , Andrén-Sandberg Å , Ansorge C 
Published: June 2016

Abstract

Background
Resection with curative intent has been shown to prolong survival of patients with locoregional pancreatic ductal adenocarcinoma (PDAC). However, up to 33 per cent of patients are deemed unresectable at exploratory laparotomy owing to unanticipated locally advanced or metastatic disease. In these patients, prophylactic double bypass (PDB) procedures have been considered the standard of care. The aim of this study was to compare PDB with exploratory laparotomy alone in terms of impact on postoperative course, chemotherapy and overall survival.

Methods
This retrospective observational cohort study (2004–2013) was conducted using a prospective institutional database. Patients with histologically confirmed, unresectable PDAC were included. Relationships between PDB procedures, exploratory laparotomy alone, postoperative chemotherapy and best supportive care were investigated by means of Cox regression. Overall survival was compared using Kaplan–Meier estimations and log rank test.

Results
Of 503 patients with PDAC scheduled for resection with curative intent, 104 were deemed unresectable at laparotomy (resection rate 79·3 per cent). Seventy-four patients underwent PDB procedures and 30 had exploratory laparotomy alone. PDB and exploratory laparotomy were similar in terms of perioperative mortality, initiation of chemotherapy and overall survival. Compared with best supportive care, postoperative chemotherapy prolonged survival (8·0 versus 14·4 months in locally advanced PDAC, P = 0·007; 2·3 versus 8·0 months in metastatic PDAC, P &lt; 0·001). Patients undergoing chemotherapy following exploratory laparotomy alone had longer median overall survival than patients undergoing chemotherapy following PDB procedures (16·3 versus 10·3 months; P = 0·040).

Conclusion
Patients with pancreatic cancer deemed unresectable at laparotomy may derive survival benefit from subsequent chemotherapy as opposed to supportive care alone. At laparotomy, proceeding with a bypass procedure for prophylactic symptom control may be prognostically unfavourable.
Development of a web interface for performing morphological operations on CUDA platform
Authors: Kuşcu Ömer , Çetiner Halit , Çetin Özdemir 
Published: June 2016

ABSTRACTIn order to make use of the performance advantages offered by modern graphics processing units (GPUs), certain image‐processing methods are used on GPU platforms. This study presents a web‐based interface, named cuDO‐Lab, whose capabilities include morphological operations. Different from other similar studies, using this interface, experimental studies can be done on both CPU and GPU platforms. NVIDIA®'s Compute Unified Device Architecture (CUDA®) platform was employed to perform GPU operations. Thanks to cuDO‐Lab, students can perform basic morphological operations without paying for licenses or requiring hardware such as CUDA® enabled GPU and software or driver installations. The cuDO‐Lab also offers a responsive web‐user interface, so the laboratory can be accessed from many devices, such as phones, tablets, laptops, and personal computers, with any screen resolution. This offers time savings, ease of use, and access from anywhere. © 2016 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:787–798, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21751
Prognostic value of health‐related quality of life for death risk stratification in patients with unresectable glioblastoma
Authors: Paquette Brice , Vernerey Dewi , Chauffert Bruno , Dabakuyo Sandrine , Feuvret Loic , Taillandier Luc , Frappaz Didier , Taillia Hervé , Schott Roland , Ducray François , Fabbro Michel , Tennevet Isabelle , Ghiringhelli François , Guillamo Jean‐Sébastien , Durando Xavier , Castera Daniel , Frenay Marc , Campello Chantal , Dalban Cécile , Skrzypski Jérome , Chinot Olivier , Anota Amélie , Bonnetain Franck 
Published: June 2016

AbstractGlioblastoma is the most common malignant brain tumor in adults. Baseline health‐related quality of life (HRQoL) is a major subject of concern for these patients. We aimed to assess the independent prognostic value of HRQoL in unresectable glioblastoma (UGB) patients for death risk stratification. One hundred and thirty‐four patients with UGB were enrolled from the TEMAVIR trial. HRQoL was evaluated at baseline using the EORTC QLQ‐C30 and BN20 brain cancer module. Clinical and HRQoL parameters were evaluated in univariable and multivariable Cox analysis as prognostic factors for overall survival (OS). Performance assessment and internal validation of the final model were evaluated with Harrel's C‐index, calibration plot, and bootstrap sample procedure. Two OS independent predictors were identified: future uncertainty and sensitivity deficit. The final model exhibited good calibration and acceptable discrimination (C statistic = 0.63). The internal validity of the model was verified with robust uncertainties around the hazard ratio. The prognostic score identified three groups of patients with distinctly different risk profiles with median OS estimated at 16.2, 9.2, and 4.5 months. We demonstrated the additional prognostic value of HRQoL in UGB for death risk stratification and provided a score that may help to guide clinical management and stratification in future clinical trials.
Brand placement disclosure effects on persuasion: The moderating role of consumer self‐control
Authors: Janssen Loes , Fransen Marieke L. , Wulff Rebecca , van Reijmersdal Eva A. 
Published: June 2016

AbstractThe inclusion of branded products in media entertainment has become a popular marketing strategy, because viewers are less likely to recognize the persuasive intent of sponsored content as compared with traditional advertising. To guarantee fair communication and protect consumers against unobtrusive persuasion attempts, European media policy has obligated broadcasters to disclose the presence of brand placement in their television shows. Recent studies demonstrate that disclosures raise viewers' persuasion knowledge; however, the circumstances under which brand placement disclosures may affect brand evaluations and resistance to the persuasive impact of brand placement are still unclear. In two experiments, we uncovered self‐control depletion as an important moderator of disclosure effects on brand evaluations and resistance to brand placement influence. Whereas disclosures increase resistance and decrease persuasion for viewers not depleted of their self‐control, disclosures do not affect resistance and even result in more favorable brand evaluations when viewers' self‐control is depleted by a previous self‐control task. Because a state of self‐control depletion can be perceived as the “couch‐potato” mindset in which people expose themselves to entertaining television content, our findings imply that instead of protecting consumers from hidden persuasion, disclosures may unintentionally increase the persuasive effects of brand placement. We discuss several possible mechanisms that could explain our findings. Copyright © 2016 John Wiley & Sons, Ltd.
Structure and Stability of Carbohydrate–Lipid Interactions. Methylmannose Polysaccharide–Fatty Acid Complexes
Authors: Liu Lan , Siuda Iwona , Richards Michele R. , Renaud Justin , Kitova Elena N. , Mayer Paul M. , Tieleman D. Peter , Lowary Todd L. , Klassen John S. 
Published: June 2016

AbstractWe report a detailed study of the structure and stability of carbohydrate–lipid interactions. Complexes of a methylmannose polysaccharide (MMP) derivative and fatty acids (FAs) served as model systems. The dependence of solution affinities and gas‐phase dissociation activation energies (Ea) on FA length indicates a dominant role of carbohydrate–lipid interactions in stabilizing (MMP+FA) complexes. Solution 1H NMR results reveal weak interactions between MMP methyl groups and FA acyl chain; MD simulations suggest the complexes are disordered. The contribution of FA methylene groups to the Ea is similar to that of heats of transfer of n‐alkanes from the gas phase to polar solvents, thus suggesting that MMP binds lipids through dipole‐induced dipole interactions. The MD results point to hydrophobic interactions and H‐bonds with the FA carboxyl group. Comparison of collision cross sections of deprotonated (MMP+FA) ions with MD structures suggests that the gaseous complexes are disordered.
Enhanced Reactivity of Water Clusters towards Oxidation in Water/Acetonitrile Mixtures
Authors: Hidalgo‐Acosta Jonnathan C. , Scanlon Micheál D. , Méndez Manuel A. , Peljo Pekka , Opallo Marcin , Girault Hubert H. 
Published: June 2016

AbstractThe water oxidation process in acidified water/acetonitrile mixtures was studied by cyclic voltammetry using fluorinated tin oxide (FTO) electrodes modified layer‐by‐layer with deposited bilayers of positively charged poly(diallyldimethylammonium chloride) (PDDA) polymer and negatively charged citrate‐stabilized iridium oxide (IrO2) nanoparticles. The voltammetric profiles obtained at high water contents resemble those in aqueous media and remain approximately unchanged. However, as the water content decreases below a water mole fraction (XH2O) of 0.6, a tipping point is reached and the onset potential for water oxidation gradually decreases. This reflects an enhanced reactivity, and therefore lower overpotential, of water molecules towards oxidation in water/acetonitrile mixtures. These lower kinetic barriers towards water oxidation are rationalized based on the degradation of the hydrogen bond network upon the formation of water/acetonitrile mixtures. Thus, as the ice‐like structure of neat water transitions to clusters and low‐bonded oligomers, these water molecules in more “free” states exhibit an enhanced susceptibility to water oxidation.
Effective Electrochemical Sterilization Based on Electrocatalysis of Oxygen Reduction by Multiwalled Carbon Nanotubes
Authors: Li Zheng‐Hong , You Shi‐Jie , Gong Xiao‐Bo , Wan Xiao‐Yun , Ren Nan‐Qi 
Published: June 2016

AbstractDisinfection of drinking water is crucial for protecting the public from disease. It is therefore important to develop high‐efficiency, low‐cost and byproduct‐free technology for the effective deactivation of organisms or pathogens in water. A study on electrochemical disinfection based on the oxygen reduction reaction (ORR) catalyzed by multiwalled carbon nanotubes (MWCNTs) is reported. MWCNTs demonstrated higher activity and comparable selectivity compared with carbon blacks toward two‐electron ORR with the formation of hydrogen peroxide. By optimizing the operating conditions (pH 7.0, 50 mmol L−1 phosphate buffer concentration, current density 15 mA cm−2), a sterilization efficiency of 99.9 % toward E. coli is achieved following electrolysis for 15 min. The oxidative species attack the cell wall of E. coli, leading to the bursting of the cell membrane and the isolation of intracellular components. Based on electrochemical disinfection driven by two‐electron ORR on MWCNTs, microorganisms are removed with an efficiency of 99.9 % from the effluent of secondary clarification from a municipal wastewater treatment plant. Owing to lower energy consumption for the ORR at lower potential, this study provides a proof‐of‐concept demonstration of a more effective method for disinfection.
Restraining Capacity Increase To Achieve Ultrastable Lithium Storage: Case Study of a Manganese(II) Oxide/Graphene‐Based Nanohybrid and Its Full‐Cell Performance
Authors: Liu Dai‐Huo , Li Wei , Wan Fang , Fan Chao‐Ying , Wang Ying‐Ying , Zhang Lin‐Lin , Lü Hong‐Yan , Xing Yue‐Ming , Zhang Xiao‐Hua , Wu Xing‐Long 
Published: June 2016

AbstractAs is well known, a gradual increase in capacity during cycling is a common phenomenon in previously reported oxide‐based anodes for lithium‐ion batteries. However, not only may this be superfluous for practical applications, but it may also imply the presence of some electrochemical instabilities and side reactions. To achieve ultrastable Li storage without such a gradual increase in capacity, the mechanism of this increase by using a MnO/graphene‐based nanohybrid (MnO@C/RGO) as an example was comprehensively explored. Then, the gradual increase behavior of the specific capacity was effectively restrained by rationally optimizing the cutoff voltage, which resulted in the MnO@C/RGO electrode maintaining a nearly constant capacity during cycling at different current densities. Taking the high current density of 2 A g−1 as an example, there was no clear capacity change (increase/attenuation) even over 2000 cycles with stable coulombic efficiencies of around 99.7 %. This ultrastable Li‐storage capability should mainly benefit from rational testing parameters and an optimal 3D conductive network. More importantly and interestingly, full cells were also assembled and tested by coupling MnO@C/RGO and commercial LiFePO4 as the anode and cathode materials, respectively. The full cells impressively exhibited superior rate performance and excellent cycling stability.
Analyzing Electrochemiluminescence Mechanisms of Thiophene–Triazole–Thiophene Luminophores with In Situ Spectroscopy
Authors: Li Michelle S. M. , Chu Kenneth , Price Jacquelyn T. , Jones Nathan D. , Ding Zhifeng 
Published: June 2016

AbstractHerein, we report the electrochemical and electrochemiluminescence (ECL) study of thiophene luminophores, 1‐[2,2′]bithiophenyl‐4‐yl‐4‐thiophen‐2‐yl‐1H‐[1,2,3]triazole (TTT) and 4‐thiophen‐2‐yl‐1‐thiophen‐3‐yl‐1H‐[1,2,3]triazole (TT), in N,N‐dimethylformamide (DMF). Differential pulse voltammetry was used to determine the oxidation and reduction potentials of the two compounds. TTT and TT in DMF exhibited relatively weak ECL efficiencies following the annihilation mechanism. However, ECL was enhanced with co‐reactants, persulfate, benzoyl peroxide, and tri‐n‐propylamine. In these experiments, TTT displayed stronger ECL activity than TT, due to the quasireversible nature of the reduction reactions. Spooling ECL spectroscopy was utilized to gain analytical insight into light‐emission mechanisms. It was shown that whereas these two thiophene compounds could form photoinduced excited monomers, excimers were generated mainly in their co‐reactant ECL paths.
Engineering Porous Organic Cage Crystals with Increased Acid Gas Resistance
Authors: Zhu Guanghui , Hoffman Christopher D. , Liu Yang , Bhattacharyya Souryadeep , Tumuluri Uma , Jue Melinda L. , Wu Zili , Sholl David S. , Nair Sankar , Jones Christopher W. , Lively Ryan P. 
Published: June 2016

AbstractBoth known and new CC3‐based porous organic cages are prepared and exposed to acidic SO2 in vapor and liquid conditions. Distinct differences in the stability of the CC3 cages exist depending on the chirality of the diamine linkers used. The acid catalyzed CC3 degradation mechanism is probed via in situ IR and a degradation pathway is proposed and supported with computational results. CC3 crystals synthesized with racemic mixtures of diaminocyclohexane exhibited enhanced stability compared to CC3‐R and CC3‐S. Confocal fluorescent microscope images reveal that the stability difference in CC3 species originates from an abundance of mesoporous grain boundaries in CC3‐R and CC3‐S, allowing facile access of aqueous SO2 throughout the crystal, promoting decomposition. These grain boundaries are absent from CC3 crystals made with racemic linkers.
Porous Mn2O3: A Low‐Cost Electrocatalyst for Oxygen Reduction Reaction in Alkaline Media with Comparable Activity to Pt/C
Authors: Wang Wenhai , Geng Jing , Kuai Long , Li Min , Geng Baoyou 
Published: June 2016

AbstractPreparing nonprecious metal catalysts with high activity in the oxygen reduction reaction (ORR) can promote the development of energy conversion devices. Support‐free porous Mn2O3 was synthesized by a facile aerosol‐spray‐assisted approach (ASAA) and subsequent thermal treatment, and exhibited ORR activity that is comparable to commercial Pt/C The catalyst also exhibits notably higher activity than other Mn‐based oxides, such as Mn3O4 and MnO2. The rotating ring disk electrode (RRDE) study indicates a typical 4‐electron ORR pathway on Mn2O3. Furthermore, the porous Mn2O3 demonstrates considerable stability and a good methanol tolerance in alkaline media. In light of the low cost and high earth abundance of Mn, the highly active Mn2O3 is a promising candidate to be used as a cathode material in metal–air batteries and alkaline fuel cells.
ChemInform Abstract: Synthesis, Single‐Crystal Structure Determination and Raman Spectra of the Tricyanomelaminates NaA5 [C6N9]2·4H2O (A: Rb, Cs).
Authors: Reckeweg Olaf , Schulz Armin , DiSalvo Francis J. 
Published: June 2016

AbstractTransparent colorless crystals of the title compounds are prepared from of solutions of Na3[C6N9] and RbF or CsF in boiling water by slow evaporation at room temperature.
ChemInform Abstract: Stabilization of 3d Transition Metal Hydrido Complexes in SrH2Mg2[Co(I)H5], BaH2Mg5[Co(‐I)H4]2, and RbH2Mg5[Co(‐I)H4Ni(0)H4] via Easily Polarizable Hydride Ligands.
Authors: Fahlquist Henrik , Moser David , Noreus Dag , Refson Keith , Parker Stewart F. 
Published: June 2016

AbstractThe structure and bonding of the new title compounds are characterized by powder XRD, neutron diffraction, inelastic neutron scattering, and DFT calculations.
ChemInform Abstract: Michael Addition Catalyzed by Difluorotris(pentafluoroethyl)phosphorane.
Authors: Bittner Bozena , Koppe Karsten , Frank Walter , Ignat'ev Nikolai 
Published: June 2016

AbstractMichael addition reactions of 1,3‐diketones or β‐ketoesters (Michael donors) with linear or cyclic unsaturated ketones (Michael acceptors) to give Michael products with moderate to high yields under mild reaction conditions are carried out.
ChemInform Abstract: Iridium‐Catalyzed Asymmetric Allylic Substitutions with Bulky Amines/Oxidative Double Bond Cleavage — Entry into the Reetz Synthesis of Amino Alcohols.
Authors: Seehafer Kai , Malakar Chandi C. , Bender Markus , Qu Jianping , Liang Chen , Helmchen Guenter 
Published: June 2016

AbstractBranched allylic amines are synthesized and transformed into N‐protected amino aldehydes.
ChemInform Abstract: From Protected‐Hydroxy Acylsilanes to Functionalized Silyl Enol Ethers and Applications in Mukaiyama Aldol Reactions.
Authors: Ruiz Johal , Karre Nagaraju , Roisnel Thierry , Chandrasekhar Srivari , Gree Rene 
Published: June 2016

AbstractThe reaction of protected β‐hydroxy acylsilanes (I) and (XII) with sulfones provides (E)‐silyl enol ethers, whereas the reaction with Grignard reagent (V) give the (Z)‐isomers (VI) as sole products.
ChemInform Abstract: Penta‐2,4‐dien‐1‐ones by Formal [3 + 2] Cycloaddition‐Rearrangement of Electron‐Deficient Diethyl 2‐(Dicyanomethylene)malonate with Alkynes.
Authors: Donckele Etienne J. , Reekie Tristan A. , Trapp Nils , Diederich Francois 
Published: June 2016

AbstractThe title reaction proceeds with excellent regioselectivity under catalyst free conditions.
ChemInform Abstract: Phosphanamine‐Functionalized Magnetic Nanoparticles (PAFMNP): An Efficient Magnetic Recyclable Ligand for the Pd‐Catalyzed Heck Reaction of Chloroarenes.
Authors: Panahi Farhad , Zarnaghash Narges , Khalafi‐Nezhad Ali 
Published: June 2016

AbstractHeck reaction of chloroarenes (I) with vinyl compounds (II) is accomplished using title nanoparticles as catalyst.
ChemInform Abstract: Enantioselective Construction of Aryl‐Substituted All‐Carbon Quaternary Stereocenters by Using Tertiary Amine‐Thiourea‐Catalyzed Michael Additions.
Authors: Chen Peng , Bao Xu , Zhang Le‐Fen , Liu Guo‐Jie , Jiang Yi‐Jun 
Published: June 2016

AbstractMichael addition of α‐cyanoketones and acrylates in the presence of chiral cinchonidine catalyst (CJN) produces the corresponding Michael adducts in high yields with moderate to good enantioselectivities.
ChemInform Abstract: Metal Free Bi(hetero)aryl Synthesis: A Benzyne Truce—Smiles Rearrangement.
Authors: Holden Catherine M. , Sohel Shariar M. A. , Greaney Michael F. 
Published: June 2016

AbstractA new benzyne transformation is described that affords versatile biaryl structures without using any transition‐metal catalysts or organometallic building blocks.
ChemInform Abstract: Gold‐Catalyzed Intramolecular Tandem Cyclization of Indole‐Ynamides: Diastereoselective Synthesis of Spirocyclic Pyrrolidinoindolines.
Authors: Zheng Nan , Chang Yuan‐Yuan , Zhang Li‐Jie , Gong Jian‐Xian , Yang Zhen 
Published: June 2016

AbstractTetracyclic spirocyclic pyrrolidinoindolines bearing an all‐carbon quaternary stereocenter are synthesized in a single step under mild reaction conditions.
ChemInform Abstract: One‐Pot Transformation of Aliphatic Carboxylic Acids into N‐Alkylsuccinimides with NIS and NCS/NaI.
Authors: Nakai Yuhta , Moriyama Katsuhiko , Togo Hideo 
Published: June 2016

AbstractTreatment of acids (I) with NIS affords the corresponding alkyl iodides.
ChemInform Abstract: Synthesis and Cytotoxicity Evaluation of New 3‐Substituted 4‐(4‐Methyloxy phenyl)‐1H‐pyrrole Derivatives.
Authors: Zhan Xiaoping , Lan Lan , Zhang Yuankui , Chen Jian , Zhao Kai , Wang Shuai , Xin Yuxuan , Mao Zhenmin 
Published: June 2016

AbstractThe title compounds (V) exhibit a broad‐spectrum of anticancer activities.