bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of Resting Metabolic Rate Prediction Equations in Athletes
Authors: Jagim Andrew R. , Camic Clayton L. , Kisiolek Jacob , Luedke Joel , Erickson Jacob , Jones Margaret T. , Oliver Jonathan M. 
Published: July 2017

Abstract
Jagim, AR, Camic, CL, Kisiolek, J, Luedke, J, Erickson, J, Jones, MT, and Oliver, JM. Accuracy of resting metabolic rate prediction equations in athletes. J Strength Cond Res 32(7): 1875–1881, 2018—The purpose of this study was to determine the accuracy of 5 different resting metabolic rate (RMR) prediction equations in male and female athletes. Twenty-two female (19.7 ± 1.4 years; 166.2 ± 5.5 cm; 63.5 ± 7.3 kg; 49.2 ± 4.3 kg of fat-free mass (FFM); 23.4 ± 4.4 body fat (BF) percent) and 28 male (20.2 ± 1.6 years; 181.9 ± 6.1 cm; 94.5 ± 16.2 kg; 79.1 ± 7.2 kg of FFM; 15.1 ± 8.5% BF) athletes were recruited to participate in 1 day of metabolic testing. Assessments comprised RMR measurements using indirect calorimetry, and body composition analyses using air displacement plethysmography. One-way repeated-measures analysis of variance with follow-up paired t tests were selected to determine differences between indirect calorimetry and 5 RMR prediction equations. Linear regression analysis was used to assess the accuracy of each RMR prediction method. An alpha level of p ≤ 0.05 was used to determine statistical significance. All the prediction equations significantly underestimated RMR while the Cunningham equation had the smallest mean difference (−165 kcals). In men, the Harris-Benedict equation was found to be the best prediction formula with the lowest root-mean-square prediction error value of 284 kcals. In women, the Cunningham equation was found to be the best prediction equation with the lowest root-mean-squared error value of 110 kcals. Resting metabolic rate prediction equations consistently seem to underestimate RMR in male and female athletes. The Harris-Benedict equation seems to be most accurate for male athletes, whereas the Cunningham equation may be better suited for female athletes.
Understanding Anthropometric Characteristics Associated With Performance in Manual Lifting Tasks
Authors: Beck Ben , Middleton Kane J. , Billing Daniel C. , Caldwell Joanne N. , Carstairs Greg L. 
Published: July 2017

Abstract
Beck, B, Middleton, KJ, Billing, DC, Caldwell, JN, and Carstairs, GL. Understanding anthropometric characteristics associated with performance in manual lifting tasks. J Strength Cond Res 33(3): 755–761, 2019—Manual lifting is an essential military job task and is commonly linked to occupational injury. Methods to reduce injury risk focus on ensuring that employees have the requisite physical capacity to safely conduct critical job tasks. The aim of this study was to investigate which anthropometric characteristics are associated with lifting performance to inform targeted training programs for job-critical lifting tasks. Sixty-three (42 men and 21 women) participants conducted 3 maximal lifts to a platform (pack lift to 1.5 m, box lift to 1.3 m and box lift to 1.5 m). A dual-energy x-ray absorptiometry scan was used to quantify anthropometric characteristics (body region–specific lean mass and fat mass). Although anthropometric measures were strongly associated with each other, multivariable linear regression revealed that a significant proportion of the total variation in lifting performance in each of the 3 tasks was explained by upper-arm lean mass (pack lift: β = 5.42, p < 0.001; box lift 1.3 m: β = 5.64, p < 0.001; box lift 1.5 m: β = 7.00, p < 0.001). Leg lean mass also significantly contributed to the variation of pack lift performance (β = 0.93, p = 0.01). When controlling for key anthropometric characteristics in these 3 tasks, separate analyses showed no significant effect of sex or stature on lift performance. These results suggest that the perceived limitations of stature and sex may be overcome by targeted training programs to improve specific physical characteristics associated with lifting performance.
Entrevista com Mariana Estevão: A Prática da Arquitetura e Urbanismo com a Promoção à Saúde da População Brasileira
Authors: Estevão Mariana , Medvedovski Nirce Saffer 
Published: July 2017

Nossa prática em extensão junto a comunidades em situação de vulnerabilidade social e ambiental nos aproximou da Arquiteta Mariana Estevão, através do projeto de pesquisa MORAR TS, financiado pelo FINEP, que visava aplicar as tecnologias sociais à promoção da habitação popular. Nesta entrevista procuramos encontrar os elos que unem a promoção da saúde à prática da arquitetura e urbanismo. Trazemos as reflexões da coordenadora da ONG Soluções Urbanas / Instituto Vital Brazil, que vem desenvolvendo desde 2008 a metodologia do Projeto Arquiteto de Família, promovendo melhorias habitacionais com foco na habitação saudável por meio da assistência técnica profissional e desenvolvimento de tecnologias sociais.
Competências desenvolvidas por equipe de saúde da família sobre o acolhimento após atividade educativa
Authors: HENTGES Isabel Cristina , COGO Ana Luísa Petersen 
Published: July 2017

Objetivo: identificar o conhecimento, as habilidades e as atitudes sobre acolhimento desenvolvidas por uma Equipe de Saúde. Métodos: pesquisa qualitativa do tipo estudo de caso realizado com 13 profissionais de uma Equipe de Saúde da Família após terem participado de atividade educativa em 2013 sobre o tema acolhimento. Os dados foram obtidos por entrevista grupal e analisados pela análise de conteúdo temática. Projeto aprovado por Comitê de Ética em Pesquisa (CAAE 12552613.6.0000.5347). Resultados: nas falas dos participantes emergiram os temas: ‘conhecimento sobre acolhimento’, ‘atitudes sobre o acolhimento’ e ‘habilidades sobre o acolhimento’. Considerações Finais: o estudo sinalizou a importância de fortalecer as competências do acolhimento envolvendo todos, os membros da Equipe de Saúde da Família.
Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSweMouse Models of Tauopathy and Amyloidosis
Authors: Briggs Denise Isabelle , Defensor Erwin , Memar Ardestani Pooneh , Yi Bitna , Halpain Michelle , Seabrook Guy , Shamloo Mehrdad 
Published: July 2017

AbstractEmerging evidence suggests that endoplasmic reticulum (ER) stress may be involved in the pathogenesis of Alzheimer’s disease (AD). Recently, pharmacological modulation of the eukaryotic translation initiation factor-2 (eIF2α) pathway was achieved using an integrated stress response inhibitor (ISRIB). While members of this signaling cascade have been suggested as potential therapeutic targets for neurodegeneration, the biological significance of this pathway has not been comprehensively assessed in animal models of AD. The present study investigated the ER stress pathway and its long-term modulation utilizingin vitroandin vivoexperimental models of tauopathy (MAPT P301S)PS19 and amyloidosis (APPSwe). We report that thapsigargin induces activating transcription factor-4 (ATF4) in primary cortical neurons (PCNs) derived from rat and APPSwenontransgenic (nTg) and transgenic (Tg) mice. ISRIB mitigated the induction of ATF4 in PCNs generated from wild-type (WT) but not APPSwemice despite partially restoring thapsigargin-induced translational repression in nTg PCNs.In vivo, C57BL/6J and PS19 mice received prolonged, once-daily administration of ISRIB. While the compound was well tolerated by PS19 and C57BL/6J mice, APPSwemice treated per this schedule displayed significant mortality. Thus, the dose was reduced and administered only on behavioral test days. ISRIB did not improve learning and memory function in APPSweTg mice. While ISRIB did not reduce tau-related neuropathology in PS19 Tg mice, no evidence of ER stress-related dysfunction was observed in either of these Tg models. Taken together, the significance of ER stress and the relevance of these models to the etiology of AD require further investigation.
Untangling Heteroplasmy, Structure, and Evolution of an Atypical Mitochondrial Genome by PacBio Sequencing
Authors: Peccoud Jean , Chebbi Mohamed Amine , Cormier Alexandre , Moumen Bouziane , Gilbert Clément , Marcadé Isabelle , Chandler Christopher , Cordaux Richard 
Published: July 2017

Abstract
The highly compact mitochondrial (mt) genome of terrestrial isopods (Oniscidae) presents two unusual features. First, several loci can individually encode two tRNAs, thanks to single nucleotide polymorphisms at anticodon sites. Within-individual variation (heteroplasmy) at these loci is thought to have been maintained for millions of years because individuals that do not carry all tRNA genes die, resulting in strong balancing selection. Second, the oniscid mtDNA genome comes in two conformations: a ∼14 kb linear monomer and a ∼28 kb circular dimer comprising two monomer units fused in palindrome. We hypothesized that heteroplasmy actually results from two genome units of the same dimeric molecule carrying different tRNA genes at mirrored loci. This hypothesis, however, contradicts the earlier proposition that dimeric molecules result from the replication of linear monomers—a process that should yield totally identical genome units within a dimer. To solve this contradiction, we used the SMRT (PacBio) technology to sequence mirrored tRNA loci in single dimeric molecules. We show that dimers do present different tRNA genes at mirrored loci; thus covalent linkage, rather than balancing selection, maintains vital variation at anticodons. We also leveraged unique features of the SMRT technology to detect linear monomers closed by hairpins and carrying noncomplementary bases at anticodons. These molecules contain the necessary information to encode two tRNAs at the same locus, and suggest new mechanisms of transition between linear and circular mtDNA. Overall, our analyses clarify the evolution of an atypical mt genome where dimerization counterintuitively enabled further mtDNA compaction.
Pesantren dan Konflik Keluarga: (Studi Kasus Pesantren Alfadiliyah Ciamis)
Authors: Aripudin Acep 
Published: July 2017

The fall of pesantren have been many differents problem one and the other. In the case of Alfadiliyah in this research has been many problems: first, leadership factor, which the successor of kyai leadership from old leaders to present has not followed normally method in generally tradisional pesantren; second, there are reformation movement on understanding and tradisional practices of culture pesantren which done by generation leader pesantren after die founder. Reformation movement like it mede opportunity to struggle from internal leader family, so stimulating struggle and conflict in pesantren; third, genetical factor as the influenced situation from many problems is competition in to pesantren assets, like materials, roles and power.
Episteme Dakwatologi Komunikasi: Menakar Komunikasi Islam dalam Epsitemologi Triangular Relationship
Authors: Wahyudin Aep 
Published: July 2017

Building a paradigm on Islamic communication does not actually have to start from the scratch. Synthesis heavy foundation can be use the existing communication theories, but the more important for Muslim scholars is to create a new synthesis through meta-theories aspects which include epistemology, ontology and perspectives. Settling on the aspects of the value and ethics dimensions must be able to collaborate with monotheism and responsibilities hereafter. Islamic communication functions is to realize the meaning of the equation, thus there will be changes in attitude or behavior of the Muslim societies. While the ultimate goal of Islam is the point which stressed on the aspect communicant, not the communicator. In the aspect of social change and community development, communication tends to be positivistic and functionally oriented to the individual, instead the social system and sociocultural functions that are critical to stimulate social changes. Quality of communication regarding the values of truth, simplicity, kindness, honesty, integrity, fairness, validity of the message and sources, are the important aspect in the Islamic communication. Therefore, in this perspective, communication is established to joint Islamic Triangular Relationship between "God, man and society".
A Phase II Multi-Center Study of Bevacizumab in Combination with Ixabepilone in Subjects with Advanced Renal Cell Carcinoma
Authors: Burotto Mauricio , Edgerly Maureen , Velarde Margarita , Balasubramaniam Sanjeeve , Drabkin Harry , Gormaz Juan G. , O'Sullivan Ciara , Madan Ravi , Fojo Tito 
Published: July 2017

Abstract

Lessons Learned
Accrual to renal cell carcinoma trials remains a challenge despite the lack of prolonged response to the available treatments. The observation of three responses among the 30 patients with median progression-free survival and overall survival of 8.3 and 15 months, respectively, indicates the combination has some activity, but it is not sufficient for further development.

Background
Treatment of metastatic renal cell carcinoma (mRCC) remains suboptimal. Preclinical data have previously shown that ixabepilone, a microtubule-stabilizing agent approved for the treatment of breast cancer, is active in taxane-sensitive and -resistant cells. In this single-arm phase II trial, we investigated a combination of ixabepilone plus bevacizumab in patients with refractory mRCC.

Methods
We enrolled 30 patients with histologically confirmed mRCC, clear cell subtype, who had not been previously treated with ixabepilone or bevacizumab but had received at least one prior U.S. Food and Drug Administration (FDA)-approved treatment for renal cell carcinoma (RCC). The treatment regimen consisted of 6 mg/m2 ixabepilone per day for 5 days and 15 mg/kg bevacizumab every 21 days. After 6 cycles, the treatment interval could be extended to every 28 days. The primary endpoint was the objective response rate according to the Response Evaluation Criteria in Solid Tumors (RECIST). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and the toxicity of the combination.

Results
The median number of prior therapies was two (range per patient one to five). Patients received a median of 8 cycles of ixabepilone plus bevacizumab (range 2–54). The median follow-up was 36.4 months (range 23.5–96.5). Nineteen patients (63.3%) had stable disease as a best response. Three patients (10%) had a partial response. The median PFS was 8.3 months (95% confidence interval [CI], 4.9–10.6) and the median OS was 15.0 months (95% CI, 11.3–28.8). The total number of cycle for safety evaluation was 289. Grade 3/4 adverse events (&gt;5% incidence) included lymphopenia (16.7%), hypertension (6.7%), and leukopenia (6.7%).

Conclusion
The combination of ixabepilone and bevacizumab was well tolerated, with modest activity in second - or later-line mRCC, but it is not recommended as a therapy without further clinical development. Alternative combinations with these agents could be explored in future studies.
Pengaruh Edukasi Kesehatan Mental Intensif Terhadap Stigma pada Pengguna Layanan Kesehatan Mental
Authors: Soebiantoro Jonathan 
Published: July 2017

Stigma terhadap pengguna kesehatan mental adalah masalah yang serius di Indonesia karena tingginya angka prevalensi masalah kesehatan mental. Kami memiliki hipotesis bahwa membaca artikel psikoedukasi secara intensif mampu menurunkan stigma sosial dan pribadi yang disematkan pada pengguna layanan kesehatan mental secara signifikan. Studi ini adalah studi kuantitatif dengan metode eksperimen melibatkan 20 partisipan (Pria = 10, Wanita = 10) dengan peserta paling muda berusia 19 tahun dan paling tua 52 tahun (M = 31.00, SD = 9.038) yang dialokasikan secara acak dalam 2 grup eksperimen (kontrol dan intervensi). Studi ini menemukan bahwa stigma sosial dapat dikurangi secara signifikan dengan membaca artikel psikoedukasi studi ini secara intensif (Mann–Whitney U = 24.5, n1 = n2 = 10, p < .05, two tails). Studi kami memiliki potensi untuk mendukung program Indonesia bebas pasung dengan meneliti cara – cara mengurangi stigma pada penderita gangguan jiwa dan layanannya.
Unstable Infiltration Experiments in Dry Porous Media
Authors: Cremer C.J.M. , Schuetz C. , Neuweiler I. , Lehmann P. , Lehmann E.H. 
Published: July 2017

Core Ideas
Gravity‐driven flow was studied in the presence of lenticular heterogeneity.
The importance of finger impingement position on heterogeneities was emphasized.
These experiments present a data set for testing of extended Richards' models.
Prediction of infiltration in porous media is challenged by finger formation and unstable displacement of the wetting front. We present a systematic experimental study on the effect of packings and infiltration rates on unstable flow into initially dry porous media. We conducted small two‐ and three‐dimensional experiments where water contents were measured with neutron radiography and larger two‐dimensional experiments, which we evaluated by obtaining commonly used finger properties such as width and velocity from image analysis. Our results from experiments in macroscopically homogeneous packings were tested for correspondence with theoretical finger property predictions and are in good agreement. For the smaller experiments, water content profiles including “overshoots” at the finger tips as well as finger properties depending on the packing matched well results reported in the literature. For all homogeneous experiments, we found a strong dependence of finger properties on porosity. Homogeneous experiments served as reference cases for comparison with larger two‐dimensional experiments where heterogeneity was induced by block‐shaped inclusions. Unstable flow propagation in heterogeneous experiments was documented by inclusion fill rates in addition to finger properties. We found a multifaceted finger propagation behavior that depends on the impingement position of instabilities on an inclusion. Thereby, we are able to show that the location of the impingement on an inclusion is crucial to the filling rate of the inclusion and the propagation velocity of the finger. Results from the conducted experiments present a data set for testing of extended Richards' models.
Characteristics of Acoustic Emissions from Soil Subjected to Confined Uniaxial Compression
Authors: Naderi-Boldaji Mojtaba , Bahrami Mostafa , Keller Thomas , Or Dani 
Published: July 2017

Core IdeasAcoustic emissions (AEs) reveal information on soil deformation processes.We studied AEs during loading–unloading–reloading cycles under confined compression.The number of AE hits reflected well the soil deformation regimes.Soil compression and swelling indices correlate with AE parameters.The Gutenberg–Richter power lawbvalue varied with wet soil yield stress.Application of mechanical stresses to soil results in deformation, microfracturing, particle motion, and liquid reconfiguration that may release measurable amounts of stored elastic energy in the form of acoustic emissions (AEs). This study aimed to systematically study AE characteristics during confined uniaxial compression of soil samples and link various AE parameters to soil deformation regimes. We hypothesized that variations in AE characteristics could offer new insights into the transition between elastic and plastic soil deformation and noninvasively identify the onset of yield stress. We subjected soil samples at known water contents to a loading–unloading–reloading cycle under uniaxial compression using an oedometer coupled with an AE monitoring system. The soil was a sandy loam equilibrated with two initial gravimetric water contents (12 and 25%) and two initial bulk densities (1.3 and 1.55 Mg m−3) for each water content. Observed AE event numbers (hits) and their energy content (E) varied during stress application to soil samples. Close agreement was found between soil yield stress deduced from normalized cumulative AE parameters and measured stress–void ratio curves (precompression stress, σpc) for the dry soil; however, the yield stress deduced from AE parameters was significantly larger than σpcfor the wet soil. Swelling and compression indices were strongly correlated to AE hits andE, respectively. The preliminary results illustrate the potential of monitoring passive AE during load application to characterize soil mechanical parameters (potentially in situ). Nevertheless, additional studies with controlled pore water pressure and a range of soil types would be required to generalize these findings to offer a robust AE‐based method.
Caracteres anatómicos y fitoquímicos del tallo y raíz de Mammillaria uncinata (Cactaceae)
Authors: Loza-Cornejo Sofía , Aparicio-Fernández Xochitl , Patakfalvi Rita Judit , Rosas-Saito Greta Hanako 
Published: July 2017

Antecedentes y Objetivos: Los integrantes de la familia Cactaceae subsisten a través de adaptaciones anatómicas y metabólicas como la síntesis de metabolitos primarios y secundarios con funciones específicas que les permiten desarrollarse en regiones áridas y semiáridas. Mammillaria es un género perteneciente a la tribu Cacteae y la literatura con respecto a sus caracteres anatómicos y fitoquímicos es escasa. Particularmente para la especie Mammillaria uncinata los estudios con ese tipo de enfoque son ausentes, por lo que los objetivos del presente trabajo fueron describir la estructura anatómica-histoquímica y el perfil fitoquímico del tallo y la raíz de la especie con la finalidad de contribuir al conocimiento de su biología y composición química.Métodos: El estudio se realizó con ejemplares recolectados en la región Altos Norte de Jalisco, México. Se emplearon la microtécnica convencional de inclusión en parafina y técnicas histoquímicas para la descripción de los caracteres anatómicos e histoquímicos, así como técnicas cualitativas para el estudio del perfil fitoquímico.Resultados clave: Algunos de los caracteres anatómicos más distintivos son laticíferos que producen un látex lechoso y cristales de morfología variable en el tallo. El análisis del perfil fitoquímico reveló la presencia abundante de metabolitos secundarios en el tallo, incluyendo alcaloides, esteroles, flavonoides y saponinas, mientras que en la raíz únicamente se detectó, de manera escasa, la presencia de esteroles y saponinas.Conclusiones: El estudio mostró la presencia, en Mammillaria uncinata, de caracteres anatómicos similares a otras especies de Cactaceae, así como la abundancia de fitoquímicos con potencial aplicación en diferentes áreas.
Maternal-calf relationships and their influence on calves up to 120 days
Authors: Souza-Conde AL Emanoela , V. Andrea María , Conde L Marcy , Delgado-Mendez Jesus , Souza Fagner C. , Paranhos da Costa JR Mateus , Paranhos da Costa JR Mateus , De Bittencourt dos SC Thereza CB , De Oliveira N Kaliane 
Published: July 2017

Objectives. To research parental behavior and measure the weight of Nelore and Guzerat calves up to 120 days of age, collecting data from birth up to the first lactation. Materials and methods. Seven different corporal positions were considered to obtain specific data for each of the following categories: time to stand (TP), time to intend to feed after standing (TPTM), weight at birth (PN), weight at 120 days (P120), and time in contact with the calf (TCC). Additionally, independent variables were also evaluated, organized by class: weight at birth (CPN), number of calvings (CNP), order of calving in relation with the herd (CLPR), time of calving (CHP), and finally, hindering to feed (CTAT). Results. There was a significant result in favor of the Nelore race over the Guzerat race. The statistical averages for Nelore and Guzerat were: Time to stand averaged 71 and 153 minutes; time to intend to feed after standing, 39 minutes for Nelore and of 114 minutes for Guzerat. For variable weight at 120 days, Nelore reached an average of 122 kg, and Guzerat 109 kg. For the time in contact with the calf variable there was no significant variance between races. Conclusions. Results showed the superiority of the Nelore race, considering it better adapted to local environmental conditions. Key words: Behavior, calves, suckling, well being (Source: CAB).