bluuebunny/crossref_metadata_2025_split huggingface dataset:
The shift step optimization of belt conveyor in self-advancing semi-continuous mining technology based on SIMIO
Authors: Li Xinwang , Li Li , Lv Huayong , Guan Tianqiang 
Published: June 2017

Purpose
This paper aims to develop a computer simulation processing method to simulate the mining operation of self-advancing semi-continuous mining technology and optimize the shift step of belt conveyor by using simulation modeling framework based on intelligent objects (SIMIO). The method would effectively solve the challenge of field testing such large-scale equipment.

Design/methodology/approach
The four operational modes of self-advancing semi-continuous mining technology at single bench had been illustrated. The operational system of this technology was analyzed and broken down to single units. By analyzing the time constitution of one operation cycle, the theoretical optimization model of shift step can be established and the optimization criteria is the time utilization ratio being maximum. Once the simulation flow was determined, a three-dimensional (3D) computer simulation model of this mining technology was developed by adapting the SIMIO simulating software to the theoretical model. The models were run to investigate the outputs from different operational modes using geological and mining data from East open-pit mine.

Findings
The result of these simulations showed that the four-mining-width one-shift (FMWOS) is at maximum production capacity during all operation modes. If transfer equipment is necessary, then this mode can adapt, but system will become more complex. There are minor differences between two-mining-width one-shift and three-mining-width one-shift. If transfer equipment is not necessary, then the two-mining-width one-shift can adapt during actual production.

Originality/value
The simulation results show that the proposed method can achieve the optimal shift step of a belt conveyor and effectively reduce the time loss caused by the coordination of multiple pieces of equipment while simultaneously improving operational efficiency.
Aging in hair follicle stem cells and niche microenvironment
Authors: Ji Jiang , Ho Bryan Siu‐Yin , Qian Ge , Xie Xiao‐Ming , Bigliardi Paul Lorenz , Bigliardi‐Qi Mei 
Published: June 2017

AbstractHair graying and hair loss are prominent and common characteristics of the elderly population. In some individuals these processes can significantly impact their quality of life, leading to depression, anxiety and other serious mental health problems. Accordingly, there has been much interest in understanding the complex physiological changes within the hair follicle in the aging individual. It is now known that hair follicles represent a prototypical stem cell niche, where both micro‐ and macroenvironmental influences are integrated alongside stem cell–stem cell and stem cell–stem niche interactions to determine hair growth or hair follicle senescence. Recent studies have identified imbalanced stem cell differentiation and altered stem cell activity as important factors during hair loss, indicating new avenues for the development of therapeutic agents to stimulate hair growth. Here, we pull together the latest findings on the hair follicle stem cell niche and the multifactorial interactions underlying the various forms of hair loss.
Novel serum metabolomics‐based approach by gas chromatography/triple quadrupole mass spectrometry for detection of human skin cancers: Candidate biomarkers
Authors: Fukumoto Takeshi , Nishiumi Shin , Fujiwara Susumu , Yoshida Masaru , Nishigori Chikako 
Published: June 2017

AbstractSkin cancer incidence rates are continuing to rise; however, if detected at an early stage, they can be cured with minimally invasive treatment. Therefore, the identification of novel and robust biomarkers for the early detection of skin cancer is required to improve the quality of life of the patient after treatment. In the present study, we aimed to identify novel biomarkers of skin cancers. We carried out serum metabolomics using gas chromatography/triple quadrupole mass spectrometry for two types of skin cancer: squamous cell carcinoma and melanoma. The changes in the expression of metabolites compared with healthy volunteers were analyzed by principal component analysis. Among all 118 metabolites, 27 in patients with squamous cell carcinoma and 33 in patients with melanoma showed significant changes in comparison with healthy volunteers. Principal component analysis showed that both skin cancer groups could be distinguished from the healthy volunteers group. We further investigated the specific metabolites most useful for these distinctions. In the squamous cell carcinoma group, these metabolites were glycerol, 4‐hydroxybenzoic acid, sebacic acid, fucose and suberic acid. In the melanoma group, these metabolites were glutamic acid, sebacic acid, suberic acid, 4‐hydroxybenzoic acid and phenylalanine. The present study identified several metabolites that were distinct for certain skin cancer types, which could potentially be used as diagnostic biomarkers leading to novel clinical management strategies.
First isolation of Rickettsia monacensis from a patient in South Korea
Authors: Kim Yeon‐Sook , Choi Yeon‐Joo , Lee Kyung‐Min , Ahn Kyu‐Joong , Kim Heung‐Chul , Klein Terry , Jiang Ju , Richards Allen , Park Kyung‐Hee , Jang Won‐Jong 
Published: June 2017

ABSTRACTA Rickettsia sp. was isolated from the blood of a patient with an acute febrile illness using the shell vial technique; the isolate was named CN45Kr and was identified by molecular assay as Rickettsia monacensis, which was first recognized as a pathogen in Spain. Sequencing analysis showed that the gltA sequence of the isolate was identical to that of Rickettsia sp. IRS3. The ompA‐5mp fragment sequence showed 100% identity to those of R. monacensis and Rickettsia sp. In56 and ompA‐3pA In56 and 100% identity to that of Rickettsia sp. IRS3. The ompB sequence was found to have 99.9% similarity to that of R. monacensis IrR/Munich. This study confirms the pathogenicity of this agent and provides additional information about its geographic distribution.
Associations between expressive and receptive language and internalizing and externalizing behaviours in a community‐based prospective study of slow‐to‐talk toddlers
Authors: Conway Laura J. , Levickis Penny A. , Mensah Fiona , McKean Cristina , Smith Kylie , Reilly Sheena 
Published: June 2017

AbstractBackgroundEvidence suggests that language and social, emotional and behavioural (SEB) difficulties are associated in children and adolescents. When these associations emerge and whether they differ by language or SEB difficulty profile is unclear. This knowledge is crucial to guide prevention and intervention programmes for children with language and SEB difficulties.AimsTo determine whether receptive and expressive language skills are associated with internalizing and externalizing behaviours in slow‐to‐talk toddlers.Methods & ProceduresIn a community‐based prospective study of 200 slow‐to‐talk children, language was measured at 24 and 36 months using Preschool Language Scale 4th Edition and at 48 months using Clinical Evaluation of Language Fundamentals—Preschool 2nd Edition. Internalizing and externalizing behaviours were measured by parent report at each age. Longitudinal data were analysed using repeated‐measures regression, with up to three observations per child. Robust standard errors were used to account for non‐independence of measures within participants. The shape of the associations were examined by fitting quadratic and cubic terms. The effects of confounders on the associations were examined.Outcomes & ResultsReceptive language had a negative linear association with internalizing behaviours after adjusting for confounders (β= –0.16, 95% [CI = –0.26, –0.07],p= .001); and a negative curved association with externalizing behaviours after adjusting for biological confounders (βquadratic= 0.08 [0.01, 0.15],p= .03,βcubic= –0.04 [–0.07, –0.02],p= .001), attenuating after adjusting for environmental confounders (βquadratic= 0.06 [–0.01, 0.13],p= .09,βcubic= –0.03 [–0.06, –0.003],p= .03). The curvature suggests that the negative association with externalizing behaviours only existed for children with either very low or very high receptive language scores. After controlling for confounders, there was no evidence that expressive language scores were associated with internalizing (β= –0.08, 95% [CI = –0.17, 0.01],p= .10) or externalizing behaviours (β= 0.03, 95% [CI = –0.09, 0.18],p= .61). Tests of interaction revealed no evidence of a differential association by age.Conclusions & ImplicationsIn 24–48‐month‐old slow‐to‐talk children, lower receptive language scores were associated with higher internalizing behaviours. The magnitude of the association was small. For children with very poor receptive language scores, lower receptive language skills were associated with higher externalizing behaviours. Young children with low receptive language abilities may be at risk of internalizing difficulties; those with very low receptive language skills may be at particular risk of externalizing difficulties. This has clinical implications for interventions for young children with receptive language difficulties.
Soluble CEACAM1 and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy
Authors: Mach Pawel , Gellhaus Alexandra , Prager Sebastian , Moore Tom , Wennemuth Gunther , Kimmig Rainer , Köninger Angela , Singer Bernhard B. 
Published: June 2017

ProblemCEACAM1 and CEACAM6 belong to the carcinoembryonic antigen (CEA) family and may play an immune‐modulatory role during pregnancy. The aim of the study was to determine the blood serum levels of soluble CEACAM1 and CEACAM6 over the course of pregnancy and postpartum.Method of studyCEACAM1 and CEACAM6 levels were determined with customized in‐house Sandwich‐enzyme‐linked immunosorbent assay (ELISA) systems. The study population (n=125) was divided into four groups according to the pregnancy trimester and postpartum. Additionally, samples of non‐pregnant women (n=14) were analyzed.ResultsSerum levels of CEACAM1 in healthy pregnant women were much lower than in non‐pregnant women, a difference not seen for CEACAM6. Comparison between the trimesters and postpartum revealed a significant difference in CEACAM1 serum levels. The highest CEACAM1 levels were detected in third trimester. These levels were statistically significantly different from the CEACAM1 levels in first trimester and second trimester. The lowest levels were observed in the second trimester. Postpartum CEACAM1 serum concentrations were slightly lower than in the third trimester, but higher than in the first trimester and significantly higher compared to levels in the second trimester.ConclusionDecreased concentration of CEACAM1 during the pregnancy suggests its regulatory role in the immune tolerance during the course of pregnancy.
Association of risk genotypes of ARMS2/LOC387715 A69S and CFH Y402H with age‐related macular degeneration with and without reticular pseudodrusen: a meta‐analysis
Authors: Jabbarpoor Bonyadi Mohammad Hossein , Yaseri Mehdi , Nikkhah Homayoun , Bonyadi Mortaza , Soheilian Masoud 
Published: June 2017

AbstractTo pool the results of published data regarding association of ARMS2/LOC387715 A69S, CFH Y402H and CFH I62V genotypes with age‐related macular degeneration (AMD) with and without reticular pseudodrusen (RPD). The results of this pooled data used to estimate the contribution of each of these genes in the pathogenesis of RPD. Heterogeneity of studies was evaluated using Cochran Q‐test and I2 index. To modify the heterogeneity in the variables, we used the random effects model. Meta‐analysis was performed using STATA. Odds ratio (OR) of genotypes in each study was calculated. Six studies of AMD with RPD and AMD without RPD cases included in this analysis. Analysis of pooled data showed that risk genotypes frequency of ARMS2 A69S was significantly different between AMD with RPD and AMD without RPD [OR = 1.82, 95% confidence interval (CI): 1.26–2.63 for GT versus GG ARMS2 A69S; OR = 2.40, 95% CI: 1.50–3.84 for TT versus GG ARMS2 A69S]. Further analysis also showed that the risk genotype frequency of CFH Y402H was not significantly different between these two groups (OR = 1.02, 95% CI: 0.69–1.50 for CT versus TT CFH Y402H; OR = 1.09, 95% CI: 0.74–1.60 for CC versus TT CFH Y402H). Comparison of above‐mentioned ORs revealed statistically higher values for GT and TT genotypes of ARMS2 A69S compared with CFH Y402H genotypes (p = 0.011, p = 0.014, respectively).Our analysis showed stronger contribution of ARMS2 in AMD with RPD group versus AMD without RPD group, in comparison with CFH genotypes.
One‐year effectiveness and safety of vedolizumab therapy for inflammatory bowel disease: a prospective multicentre cohort study
Authors: Amiot A. , Serrero M. , Peyrin‐Biroulet L. , Filippi J. , Pariente B. , Roblin X. , Buisson A. , Stefanescu C. , Trang‐Poisson C. , Altwegg R. , Marteau P. , Vaysse T. , Bourrier A. , Nancey S. , Laharie D. , Allez M. , Savoye G. , Moreau J. , Vuitton L. , Viennot S. , Aubourg A. , Pelletier A.‐L. , Bouguen G. , Abitbol V. , Gagniere C. , Bouhnik Y. ,   the OBSERV‐IBD study group and the GETAID
Published: June 2017

SummaryBackgroundWe recently showed that vedolizumab is effective in patients with Crohn's disease (CD) and ulcerative colitis (UC) with prior anti‐TNF failure in a multicentre compassionate early‐access programme before marketing authorisation was granted to vedolizumab.AimsTo assess effectiveness and safety of vedolizumab at week 54 in patients UC and CD.MethodsBetween June and December 2014, 173 patients with Crohn's disease (CD) and 121 with ulcerative colitis (UC) were treated with vedolizumab induction therapy. Among those 294 patients, 272 completed the induction period and were evaluated at the week 14 visit (161 patients with CD and 111 with UC). Disease activity was assessed using the Harvey‐Bradshaw Index for CD and the partial Mayo Clinic score for UC. The primary outcome was steroid‐free clinical remission at week 54.ResultsAt week 54, steroid‐free clinical remission rates at week 54 were 27.2% and 40.5% in patients with CD and UC respectively. In addition, the sustained steroid‐free clinical remission (from week 14 to week 54) rates were 8.1% and 19.0% respectively. No deaths were observed. Severe adverse events occurred in 17 (7.2%) patients, including six (2.5%) leading to vedolizumab discontinuation.ConclusionVedolizumab is able to maintain steroid‐free clinical remission in up to one‐third of patients with UC and CD at week 54 with a reasonable safety profile. A significant number of patients experienced loss of response during the first year of treatment, particularly in patients with CD.
Influence of opioids on immune function in patients with cancer pain: from bench to bedside
Authors: Boland Jason W , Pockley A Graham 
Published: June 2017

In patients with cancer, opioids are principally used for the management of acute surgical and chronic cancer‐related pain. However, opioids have many non‐analgesic effects, including direct and indirect effects on cancer cells and on anti‐tumour immunity (NK cells, macrophages and T‐cells). Direct effects on immune cells are manifested via opioid and non‐opioid toll‐like receptors, whereas indirect effects are manifested via the sympathetic nervous system and hypothalamic–pituitary–adrenal axis. Opioids can also decrease/alter immune cell infiltration into the tumour micro‐environment. Animal models have shown that this is not a class effect, in that morphine and fentanyl suppress NK cell cytotoxicity; buprenorphine does not affect NK cell cytotoxicity, whereas tramadol increases NK cell cytotoxicity, reducing metastasis. In healthy individuals, morphine suppresses and fentanyl enhances NK cell cytotoxicity. In patients undergoing surgery, fentanyl decreased and tramadol increased NK cell cytotoxicity; clinical outcomes were not determined. Meta‐analyses of opioid‐sparing surgical studies report an association between improved recurrence‐free and/or overall survival with regional/neuraxial anaesthesia compared with systemic opioids. In patients receiving opioids for non‐surgical cancer‐related pain, morphine has variable effects on immunity; clinical outcomes were not assessed. Although there is a potential association between systemic opioid administration and shorter survival in cancer patients with a prognosis of months to years, studies have not been designed to primarily assess survival, as a consequence of which causality cannot be apportioned. Pain is immunosuppressive, so analgesia is important. Opioids for cancer‐related pain will continue to be recommended until definitive data on the effects of opioids on clinical outcomes in specific patient groups becomes available.Linked ArticlesThis article is part of a themed section on Emerging Areas of Opioid Pharmacology. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.14/issuetoc
Reply to White et al.: Providing Perspective on Ocean Conservation Targets
Authors: O'Leary Bethan C. , Winther‐Janson Marit , Bainbridge John M. , Aitken Jemma , Hawkins Julie P. , Roberts Callum M. 
Published: June 2017

AbstractIn O'Leary et al. (2016), we undertook a quantitative synthesis (rather than a true statistical meta‐analysis) of research to consider how much of the sea should be protected to achieve various conservation and management goals. We aimed to provide perspective on the appropriateness of global marine protected area coverage targets, particularly the United Nations Sustainable Development Goal 14/Convention on Biological Diversity goals to protect >10% of the sea by 2020. White et al. (2017) question the methodology of our approach, and we offer the following response.
Kinetic modeling and thermodynamic properties of soybean cultivar (BRS257) during hydration process
Authors: Borges Cristiane Wing Chong , Jorge Luiz Mario de Matos , Jorge Regina Maria Matos 
Published: June 2017

AbstractThe hydration kinetics of transgenic soybean cultivar BRS257 was studied at temperatures 30, 40, 50, and 60 °C for 480 min. Peleg and Omoto–Jorge models and its generalized equations were used in this work to describe the kinetics of water absorption. At all temperatures, the models represented the main trends of the hydration process with deviations of less than 3%. However, the Peleg model presents the best fit to the experimental data (R2 = 0.99; P < 3.0%; RMSE = 0.97; SE = 1.07). The moisture transfer is affected by temperature, with higher absorption rates at higher temperatures and the Peleg's constant K1 decreased, while K2 was almost constant. The activation energy (Ea) = −34.797 kJ/mol and average enthalpy (ΔH) = −37.442 kJ/mol, entropy (ΔS) = −1.917E–01 kJ/mol/K, Gibbs free energy (ΔG) = 2.347E+01 kJ/mol were estimated from the adjusted parameters and Arrhenius equation. The values obtained show that hydration is not a spontaneous phenomenon. The grain density (0.97 ± 0.08 g/cm3) presented almost constant values during the experiments.Practical applicationsThe practical application of this work aims to evaluate the hydration process of the transgenic cultivar BRS257, for different conditions of time and temperature. This cultivar presents an important characteristic compared to other cultivars, because it does not require severe thermal treatment conditions to inactivate the Lipoxygenases enzymes, responsible for an adstringent taste. This work allowed to know thermodynamic properties of the hydration process. Furthermore the appropriate model is useful for future process optimization, aiming to decrease the time and the energy required.
Clinical outcome and its predictors in hemodialysis patients with critical limb ischemia undergoing endovascular therapy
Authors: Kataoka Shohei , Yamaguchi Junichi , Nakao Masashi , Jujo Kentaro , Hagiwara Nobuhisa 
Published: June 2017

ObjectivesThis study aimed to examine prognosis and causes of death in hemodialysis (HD) patients with critical limb ischemia (CLI) after endovascular therapy (EVT).BackgroundEVT is becoming a first‐line treatment in patients with CLI. Nonetheless, only a few studies have examined prognosis and its predictors in HD patients with CLI undergoing EVT, who are known to be at high‐risk. Moreover, causes of death in this population are not clarified to date.MethodsWe examined 175 consecutive patients who underwent EVT for CLI between March 2009 and March 2014.ResultsAmong these, 126 patients were dependent on HD and their 2‐year all‐cause death and 2‐year major amputation rates were 28% and 14%, respectively. Cox proportional hazards analyses revealed that lower body mass index (hazard ratio [HR] = 0.89, 95% confidence interval [CI] = 0.82‐0.98, P = 0.03) and prior stroke (HR = 2.34, 95%CI = 1.10‐4.85, P = 0.03) were independent predictors of all‐cause death, and lower serum albumin (HR = 0.44, 95%CI = 0.22‐0.92, P = 0.03) along with currently smoking (HR = 4.73, 95%CI = 1.43‐14.1, P = 0.01) were independent predictors of major amputation in HD patients. The leading cause of death in this population was infections, most of which were lower extremity infections.ConclusionsThe incidences of all‐cause death and major amputation seemed acceptable in HD patients undergoing EVT for CLI. In this high‐risk subset, management of infection might be a potential therapeutic target.
Bivalirudin versus heparin and provisional GP IIb/IIIa inhibitors in patients treated for ST‐segment elevation myocardial infarctions: Comparison of outcomes in a “real‐world” setting
Authors: Fach Andreas , Backhaus Tina , Schmucker Johannes , Zabrocki Robert , Garstka Daniela , Stehmeier Janina , Fiehn Eduard , Hambrecht Rainer , Wienbergen Harm 
Published: June 2017

IntroductionThe beneficial effects of bivalirudin during primary PCIs are controversially discussed, data on unselected patients are rare. It was the aim of the study to compare bivalirudin versus heparin and provisional glycoprotein IIb/IIIa inhibitors (GPIs) in a “real‐world” study.MethodsFrom 05/2013 until 11/2014, the STEMI‐patients in the Bremen STEMI registry were treated with periinterventional bivalirudin; before and after this period the standard anticoagulative treatment was heparin and provisional GPIs.ResultsIn 714 patients bivalirudin was used for PCI, this cohort was compared to 683 patients with heparin and provisional GPIs. In patients with bivalirudin a significantly lower rate of hospital bleedings was observed compared to patients with heparin (4.6% vs 8.1%, P < 0.01, multivariate HR 0.57, 95%CI 0.35‐0.93), in an exclusive analysis of severe bleedings a trend toward less bleedings was found in patients with bivalirudin (2.0% vs 3.5%, P = 0.07, multivariate HR 0.66, 95%CI 0.30‐1.42). The rate of stent thromboses reinfarctions and mortality was not different between the bivalirudin and the heparin group. During 1‐year follow‐up bivalirudin was associated with a lower rate of bleedings and no significant differences in stent thromboses, reinfarctions, and mortality. Bivalirudin was not associated with an excess of bleedings or stent thromboses in subgroups that are regularly underrepresented in randomized trials (older patients, women, cardiogenic shock).ConclusionsIn this “real‐world” cohort of patients with STEMI bivalirudin compared to heparin and GPIs was associated with less bleedings and no significant differences in stent thromboses, reinfarctions, and mortality during hospital and long‐term course.