bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Foreign Aid Target the Poorest?
Authors: Briggs Ryan C. 
Published: December 2016

AbstractTo examine the extent to which foreign aid reaches people at different levels of wealth in Africa, I use household surveys to measure the subnational distribution of a country's population by wealth quintiles and match this information to data on the location of aid projects from two multilateral donors. Within countries, aid disproportionately flows to regions with more of the richest people. Aid does not favor regions with more of the poorest people. These findings violate the stated preferences of the multilateral donors under study, suggesting that the donors either cannot or are not willing to exercise control over the location of aid projects within countries. The results also suggest that aid is not being allocated effectively to alleviate extreme poverty.
Grammar of Difference? The Dutch Colonial State, Labour Policies, and Social Norms on Work and Gender, c.1800–1940
Authors: van Nederveen Meerkerk Elise 
Published: December 2016

AbstractThis article investigates developments in labour policies and social norms on gender and work from a colonial perspective. It aims to analyse the extent to which state policies and societal norms influenced gendered labour relations in the Netherlands and its colony, the Netherlands Indies (present-day Indonesia). In order to investigate the influence of the state on gender and household labour relations in the Dutch empire, this paper compares as well as connects social interventions related to work and welfare in the Netherlands and the Netherlands Indies from the early nineteenth century up until World War II. At the beginning of the nineteenth century, work was seen as a means to morally discipline the poor, both in the Netherlands and the Netherlands Indies. Parallel initiatives were taken by Johannes van den Bosch, who, in 1815, established “peat colonies” in the Netherlands, aiming to transform the urban poor into industrious agrarian workers, and in 1830 introduced the Cultivation System in the Netherlands Indies, likewise to increase the industriousness of Javanese peasants. While norms were similar, the scope of changing labour relations was much vaster in the colony than in the metropole.During the nineteenth century, ideals and practices of the male breadwinner started to pervade Dutch households, and children’s and women’s labour laws were enacted. Although in practice many Dutch working-class women and children continued to work, their official numbers dropped significantly. In contrast to the metropole, the official number of working (married) women in the colony was very high, and rising over the period. Protection for women and children was introduced very late in the Netherlands Indies and only under intense pressure from the international community. Not only did Dutch politicians consider it “natural” for Indonesian women and children to work, their assumptions regarding inherent differences between Indonesian and Dutch women served to justify the protection of the latter: a fine example of what Ann Stoler and Frederick Cooper have called a “grammar of difference”.
Conquerors, Employers, and Arbiters: States and Shifts in Labour Relations 1500–2000, Introduction
Authors: Hofmeester Karin , Kessler Gijs , Moll-Murata Christine 
Published: December 2016

AbstractThe introductory article to this volume offers an analytical framework for the capacities in which states have historically affected labour relations. The framework captures the full range of possible manifestations of state power, including early states, empires, regional authorities, and city states. It distinguishes between the state as a direct actor or participant, carrying out tasks deemed essential for its functioning, and the state as an arbiter, redistributor, or regulator. As conquerors or employers, states are confronted with a basic dilemma: how to extract and allocate the labour resources required to accomplish state tasks. Borrowing from Charles Tilly, the two broad categories of capital and coercion are used as a heuristic device to bring order to the ways in which states have solved this dilemma. Contrary to Tilly’s trajectories of state formation, states’ reliance on capital or coercion is subject to a great degree of flexibility, both over time and across space. In their capacities as mediators and regulators, modern states came to have an even more profound impact on labour relations, as state building moved away from the single focus on organizing the extraction of resources to a wider mission of fostering welfare, economic development, and human capital formation.
The rise and fall of hospitalizations for skin infections in New Zealand, 2004–2014: trends by ethnicity and socioeconomic deprivation
Authors: LIM A. , RUMBALL-SMITH J. , JONES R. , KAWACHI I. 
Published: December 2016

SUMMARYSince the 1990s, New Zealand (NZ) has seen an increasing incidence of paediatric skin infections leading to hospitalization. We sought to describe the epidemiology of these infections over time. Hospital discharge data were analysed for all children admitted to any NZ public hospital from 2004 to 2014. We found the age-standardized incidence of hospitalizations due to skin infections increased during this period from 522/100 000 in 2004 to a peak of 644/100 000 in 2011, after which it declined to 524/100 000 in 2014. This decline in incidence was driven primarily by the decline in hospitalization rates in high-risk groups including children living in the most deprived areas as well as Māori and Pacific children. Recent targeted policies focused on improving healthcare access through school-based and primary care-based interventions in these high-risk groups could potentially explain the decline in hospitalization rates. However, even with the closing of the inequality gap, significant socioeconomic and ethnic health disparities persist.
Epidemiological and serological investigation of a waterborneCampylobacter jejunioutbreak in a Danish town
Authors: KUHN K. GAARDBO , FALKENHORST G. , EMBORG H.-D. , CEPER T. , TORPDAHL M. , KROGFELT K. A. , ETHELBERG S. , MØLBAK K. 
Published: December 2016

SUMMARYFollowing an unusually heavy rainfall in June 2009, a community-wide outbreak ofCampylobactergastroenteritis occurred in a small Danish town. The outbreak investigation consisted of (1) a cohort study using an e-questionnaire of disease determinants, (2) microbiological study of stool samples, (3) serological study of blood samples from cases and asymptomatic members of case households, and (4) environmental analyses of the water distribution system. The questionnaire study identified 163 cases (respondent attack rate 16%). Results showed a significant dose-response relationship between consumption of tap water and risk of gastroenteritis.Campylobacter jejunibelonging to two relatedflaAtypes were isolated from stool samples. Serum antibody levels againstCampylobacterwere significantly higher in cases than in asymptomatic persons. Water samples were positive for coliform bacteria, and the likely mode of contamination was found to be surface water leaking into the drinking-water system. This geographically constrained outbreak presented an ideal opportunity to study the serological response in persons involved in aCampylobacteroutbreak. The serology indicated that asymptomatic persons from the same household may have been exposed, during the outbreak period, toCampylobacterat doses that did not elicit symptoms or alternatively had been exposed toCampylobacterat a time prior to the outbreak, resulting in residual immunity and thus absence of clinical signs.
Distribution and origin of ground ice in University Valley, McMurdo Dry Valleys, Antarctica
Authors: Lapalme Caitlin , Lacelle Denis , Pollard Wayne , Fisher David , Davila Alfonso , Mckay Christopher P. 
Published: December 2016

AbstractGround ice is one of the most important and dynamic geologic components of permafrost; however, few studies have investigated the distribution and origin of ground ice in the McMurdo Dry Valleys of Antarctica. In this study, ice-bearing permafrost cores were collected from 18 sites in University Valley, a small hanging glacial valley in the Quartermain Mountains. Ground ice was found to be ubiquitous in the upper 2 m of permafrost soils, with excess ice contents reaching 93%, but ground ice conditions were not homogeneous. Ground ice content was variable within polygons and along the valley floor, decreasing in the centres of polygons and increasing in the shoulders of polygons towards the mouth of the valley. Ground ice also had different origins: vapour deposition, freezing of partially evaporated snow meltwater and buried glacier ice. The variability in the distribution and origin of ground ice can be attributed to ground surface temperature and moisture conditions, which separate the valley into distinct zones. Ground ice of vapour-deposition origin was predominantly situated in perennially cryotic zones, whereas ground ice formed by the freezing of evaporated snow meltwater was predominantly found in seasonally non-cryotic zones.
Biomarkers in Prodromal Parkinson Disease: a Qualitative Review
Authors: Cooper Christine A. , Chahine Lama M. 
Published: December 2016

AbstractBackground: Over the past several years, the concept of prodromal Parkinson disease (PD) has been increasingly recognized. This term refers to individuals who do not fulfill motor diagnostic criteria for PD, but who have clinical, genetic, or biomarker characteristics suggesting risk of developing PD in the future. Clinical diagnosis of prodromal PD has low specificity, prompting the need for objective biomarkers with higher specificity. In this qualitative review, we discuss objectively defined putative biomarkers for PD and prodromal PD. Methods: We searched Pubmed and Embase for articles pertaining to objective biomarkers for PD and their application in prodromal cohorts. Articles were selected based on relevance and methodology. Key Findings: Objective biomarkers of demonstrated utility in prodromal PD include ligand-based imaging and transcranial sonography. Development of serum, cerebrospinal fluid, and tissue-based biomarkers is underway, but their application in prodromal PD has yet to meaningfully occur. Combining objective biomarkers with clinical or genetic prodromal features increases the sensitivity and specificity for identifying prodromal PD. Conclusions: Several objective biomarkers for prodromal PD show promise but require further study, including their application to and validation in prodromal cohorts followed longitudinally. Accurate identification of prodromal PD will likely require a multimodal approach. (JINS, 2016, 22, 956–967)
Patterns of Cortical and Subcortical Amyloid Burden across Stages of Preclinical Alzheimer’s Disease
Authors: Edmonds Emily C. , Bangen Katherine J. , Delano-Wood Lisa , Nation Daniel A. , Furst Ansgar J. , Salmon David P. , Bondi Mark W. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: December 2016

AbstractObjectives: We examined florbetapir positron emission tomography (PET) amyloid scans across stages of preclinical Alzheimer’s disease (AD) in cortical, allocortical, and subcortical regions. Stages were characterized using empirically defined methods. Methods: A total of 312 cognitively normal Alzheimer’s Disease Neuroimaging Initiative participants completed a neuropsychological assessment and florbetapir PET scan. Participants were classified into stages of preclinical AD using (1) a novel approach based on the number of abnormal biomarkers/cognitive markers each individual possessed, and (2) National Institute on Aging and the Alzheimer’s Association (NIA-AA) criteria. Preclinical AD groups were compared to one another and to a mild cognitive impairment (MCI) sample on florbetapir standardized uptake value ratios (SUVRs) in cortical and allocortical/subcortical regions of interest (ROIs). Results: Amyloid deposition increased across stages of preclinical AD in all cortical ROIs, with SUVRs in the later stages reaching levels seen in MCI. Several subcortical areas showed a pattern of results similar to the cortical regions; however, SUVRs in the hippocampus, pallidum, and thalamus largely did not differ across stages of preclinical AD. Conclusions: Substantial amyloid accumulation in cortical areas has already occurred before one meets criteria for a clinical diagnosis. Potential explanations for the unexpected pattern of results in some allocortical/subcortical ROIs include lack of correspondence between (1) cerebrospinal fluid and florbetapir PET measures of amyloid, or between (2) subcortical florbetapir PET SUVRs and underlying neuropathology. Findings support the utility of our novel method for staging preclinical AD. By combining imaging biomarkers with detailed cognitive assessment to better characterize preclinical AD, we can advance our understanding of who is at risk for future progression. (JINS, 2016, 22, 978–990)
The theory of capital as a theory of capitalism
Authors: BRAUN EDUARD 
Published: December 2016

AbstractBefore economists and sociologists came up with their own definitions of the term ‘capital’, it was commonly understood as money invested in businesses by their owners or shareholders, and it continues to be understood this way in everyday business practice. In a recent article, Hodgson (2014) advises economists to return to this pre-Smithian usage of the term. This paper takes up Hodgson's demand and develops a theory of capital that is based upon this business notion of capital. It also argues that the Austrian theory of capital, if interpreted correctly, can serve as a starting point. Despite the conviction of its adherents to the contrary, the Austrian theory of capital is not universal or ahistorical, but dovetails with Hodgson's vision of an approach to capital that analyses historically specific features of capitalism.
Introduction to the Douglass C. North memorial issue
Authors: HODGSON GEOFFREY M. 
Published: December 2016

AbstractThis introduction considers the highly influential contribution of Douglass C. North to economic history and institutional economics, as it developed from the 1960s until his death in 2015. It sketches the evolution of his arguments concerning the roles of institutions, organizations and human agency. North's conception of the economic actor became progressively more sophisticated, by acknowledging the role of ideology and adopting insights from cognitive science. Eventually, he abandoned the proposition that institutions are generally efficient, to propose instead that sub-optimal institutional forms could persist. A few noted criticisms of North's work are also considered here, ranging from those which are arguably off the mark, to others that retain some force. The contributions to this memorial issue are outlined at the end of this introduction.
A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC
Authors: Seebacher Nicole A , Richardson Des R , Jansson Patric J 
Published: December 2016

AbstractThe intracellular distribution of a drug can cause significant variability in both activity and selectivity. Herein, we investigate the mechanism by which the anti-cancer agents, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and the clinically trialed, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), re-instate the efficacy of doxorubicin (DOX), in drug-resistant P-glycoprotein (Pgp)-expressing cells. Both Dp44mT and DpC potently target and kill Pgp-expressing tumors, while DOX effectively kills non-Pgp-expressing cancers. Thus, the combination of these agents should be considered as an effective rationalized therapy for potently treating advanced and resistant tumors that are often heterogeneous in terms of Pgp-expression. These studies demonstrate that both Dp44mT and DpC are transported into lysosomes via Pgp transport activity, where they induce lysosomal-membrane permeabilization to release DOX trapped within lysosomes. This novel strategy of loading lysosomes with DOX, followed by permeabilization with Dp44mT or DpC, results in the relocalization of stored DOX from its lysosomal 'safe house' to its nuclear targets, markedly enhancing cellular toxicity against resistant tumor cells. Notably, the combination of Dp44mT or DpC with DOX showed a very high level of synergism in multiple Pgp-expressing cell types, for example, cervical, breast and colorectal cancer cells. These studies revealed that the level of drug synergy was proportional to Pgp activity. Interestingly, synergism was ablated by inhibiting Pgp using the pharmacological inhibitor, Elacridar, or by inhibiting Pgp-expression using Pgp-silencing, demonstrating the importance of Pgp in the synergistic interaction. Furthermore, lysosomal-membrane stabilization inhibited the relocalization of DOX from lysosomes to the nucleus upon combination with Dp44mT or DpC, preventing synergism. This latter observation demonstrated the importance of lysosomal-membrane permeabilization to the synergistic interaction between these agents. The synergistic and potent anti-tumor efficacy observed between DOX and thiosemicarbazones represents a promising treatment combination for advanced cancers, which are heterogeneous and composed of non-Pgp- and Pgp-expressing tumor cells.
‘Normalizing’ the malignant phenotype of luminal breast cancer cells via alpha(v)beta(3)-integrin
Authors: Abu-Tayeh Hanan , Weidenfeld Keren , Zhilin-Roth Alisa , Schif-Zuck Sagi , Thaler Sonja , Cotarelo Cristina , Tan Tuan Z , Thiery Jean P , Green Jeffrey E , Klorin Geula , Sabo Edmond , Sleeman Jonathan P , Tzukerman Maty , Barkan Dalit 
Published: December 2016

AbstractReestablishing tissue organization of breast cancer cells into acini was previously shown to override their malignant phenotype. In our study, we demonstrate that alpha(v)beta(3) integrin (Int-αvβ3), previously shown to play a role in cancer progression, promoted differentiation and growth arrest of organoids derived from luminal A breast cancer cells grown in their relevant three-dimensional microenvironment. These organoids differentiated into normal-like acini resembling a benign stage of breast tissue. Likewise, we demonstrate that Int-αvβ3 is selectively expressed in the epithelium of the benign stage of breast tissues, and is lost during the early stages of luminal A breast cancer progression. Notably, the organoids’ reversion into normal-like acini was mediated by cancer luminal progenitor-like cells expressing both EpCAMhighCD49flowCD24+ and Int-αvβ3. Furthermore, downregulation of Notch4 expression and downstream signaling was shown to mediate Int-αvβ3-induced reversion. Intriguingly, when luminal A breast cancer cells expressing Int-αvβ3 were injected into a humanized mouse model, differentiated tumors developed when compared with that generated by control cells. Hence, our data suggest that promoting differentiation of luminal A breast cancer cells by signaling emanating from Int-αvβ3 can potentially promote ‘normalization’ of their malignant phenotype and may prevent the malignant cells from progressing.
Distinct outcomes of CRL–Nedd8 pathway inhibition reveal cancer cell plasticity
Authors: Rulina Anastasia V , Mittler Frédérique , Obeid Patricia , Gerbaud Sophie , Guyon Laurent , Sulpice Eric , Kermarrec Frédérique , Assard Nicole , Dolega Monika E , Gidrol Xavier , Balakirev Maxim Y 
Published: December 2016

AbstractInhibition of protein degradation by blocking Cullin-RING E3 ligases (CRLs) is a new approach in cancer therapy though of unknown risk because CRL inhibition may stabilize both oncoproteins and tumor suppressors. Probing CRLs in prostate cancer cells revealed a remarkable plasticity of cells with TMPRSS2-ERG translocation. CRL suppression by chemical inhibition or knockdown of RING component RBX1 led to reversible G0/G1 cell cycle arrest that prevented cell apoptosis. Conversely, complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL regulator Cand1. We analyzed cell signaling to understand how varying degrees of CRL inhibition translated to distinct cell fates. Both tumor suppressor and oncogenic cell signaling pathways and transcriptional activities were affected, with pro-metastatic Wnt/β-catenin as the most upregulated. Suppression of the NF-κB pathway contributed to anti-apoptotic effect, and androgen receptor (AR) and ERG played decisive, though opposite, roles: AR was involved in protective quiescence, whereas ERG promoted apoptosis. These data define AR–ERG interaction as a key plasticity and survival determinant in prostate cancer and suggest supplementary treatments that may overcome drug resistance mechanisms regulated by AR–ERG interaction.
Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice
Authors: Dawar Swati , Shahrin Nur Hezrin , Sladojevic Nikolina , D'Andrea Richard J , Dorstyn Loretta , Hiwase Devendra K , Kumar Sharad 
Published: December 2016

AbstractThe apoptotic cysteine protease caspase-2 has been shown to suppress tumourigenesis in mice and its reduced expression correlates with poor prognosis in some human malignancies. Caspase-2-deficient mice develop normally but show ageing-related traits and, when challenged by oncogenic stimuli or certain stress, show enhanced tumour development, often accompanied by extensive aneuploidy. As stem cells are susceptible to acquiring age-related functional defects because of their self-renewal and proliferative capacity, we examined whether loss of caspase-2 promotes such defects with age. Using young and aged Casp2−/− mice, we demonstrate that deficiency of caspase-2 results in enhanced aneuploidy and DNA damage in bone marrow (BM) cells with ageing. Furthermore, we demonstrate for the first time that caspase-2 loss results in significant increase in immunophenotypically defined short-term haematopoietic stem cells (HSCs) and multipotent progenitors fractions in BM with a skewed differentiation towards myeloid progenitors with ageing. Caspase-2 deficiency leads to enhanced granulocyte macrophage and erythroid progenitors in aged mice. Colony-forming assays and long-term culture-initiating assay further recapitulated these results. Our results provide the first evidence of caspase-2 in regulating HSC and progenitor differentiation, as well as aneuploidy, in vivo.
Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors
Authors: Falk Sebastian , Finogenova Ksenia , Melko Mireille , Benda Christian , Lykke-Andersen Søren , Jensen Torben Heick , Conti Elena 
Published: December 2016

AbstractThe eukaryotic RNA exosome participates extensively in RNA processing and degradation. In human cells, three accessory factors (RBM7, ZCCHC8 and hMTR4) interact to form the nuclear exosome targeting (NEXT) complex, which directs a subset of non-coding RNAs for exosomal degradation. Here we elucidate how RBM7 is incorporated in the NEXT complex. We identify a proline-rich segment of ZCCHC8 as the interaction site for the RNA-recognition motif (RRM) of RBM7 and present the crystal structure of the corresponding complex at 2.0 Å resolution. On the basis of the structure, we identify a proline-rich segment within the splicing factor SAP145 with strong similarity to ZCCHC8. We show that this segment of SAP145 not only binds the RRM region of another splicing factor SAP49 but also the RRM of RBM7. These dual interactions of RBM7 with the exosome and the spliceosome suggest a model whereby NEXT might recruit the exosome to degrade intronic RNAs.