bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palifermin
Authors: Cada Dennis J. , Levien Terri , Baker Danial E. 
Published: December 2017

Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late Phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. With a subscription, the monographs are sent to you in print and CD ROM forms and are available online. Monographs can be customized to meet the needs of your facility. Subscribers to the The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. If you would like information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The June 2005 monograph topics are entecavir, esomeprazole sodium, mometasone furoate inhalation powder, and bromfenac ophthalmic solution. The DUE is on entecavir.
Micafungin Sodium
Authors: Cada Dennis J. , Levien Terri , Baker Danial E. 
Published: December 2017

Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. With a subscription, the monographs are sent to you in print and CD ROM forms and are available online. Monographs can be customized to meet the needs of your facility. Subscribers to the The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. If you would like information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The August 2005 monograph topics are sildenafil citrate for pulmonary arterial hypertension, paracalcitol capsules, galsulfase, dalbavancin, and febuxostat. The DUE is on paricalcitol capsules.
Entecavir
Authors: Cada Dennis J. , Levien Terri , Baker Danial E. 
Published: December 2017

Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. With a subscription, the monographs are sent to you in print and CD ROM forms and are available online. Monographs can be customized to meet the needs of your facility. Subscribers to the The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. If you would like information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The September 2005 monograph topics are tigecycline, insulin detemir injection, tipranavir, isosorbide dinitrate/hydralazine hydrochloride, and muraglitazar. The DUE is on paricalcitol tigecycline.
Preventing Inadvertent IV Administration of Nimodopine Capsule Contents Meant for Nasogastric Administration; Depo-SubQ Provera 104 – Potential for Confusion; Wrong Patient Error; Suggested United States Adopted Names
Authors: Cohen Michael R. 
Published: December 2017

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them in your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the USP Medication Errors Reporting Program (MERP), which is presented in cooperation with the Institute for Safe Medication Practices. If you have encountered medication errors and would like to report them, you may call USP toll-free, 24 hours a day, at 800-233-7767 (800-23-ERROR). Any reports published by ISMP will be anonymous. Comments are also invited; the writers’ names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported through the ISMP ( www.ismp.org ) or USP ( www.usp.org ) Web sites or communicated directly to ISMP by calling 800-FAIL-SAFE or via E-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters’ wishes as to the level of detail included in publications.
Use of Automated Controlled Substance Cabinets for Detection of Diversion in US Hospitals: A National Study
Authors: Crowson Karren , Monk-Tutor Mary 
Published: December 2017

Purpose Use of automated controlled substance cabinets (ACSCs) for storage and distribution of narcotics can provide documentation necessary to identify and detect drug diversion. This study investigated how ACSCs are used for narcotic control in US hospitals (including a comparison of detection rates pre- and post-automations) and looked at the difference between hospitals that used ACSCs vs those that did not; it also identified hospital policies related to drug diversion. Methods A survey mailed to a national sample of 311 hospitals achieved a 22% usable response rate. Data were entered into an Excel database and analyzed using descriptive statistics; diversion detection rates were calculated per 100 beds. Detection rates were defined as the average number of employees per year that were detected diverting controlled substances over the 3-year period (both pre- and post-ACSC installation); detection rates for those still using manual systems were defined in the same way but only for the 3-year period just prior to the study. Calculation of diversion detection rates were based on respondent estimates of such occurrences. Results Over 80% of the respondents indicated that their institution used an ACSC, and 62% provided the necessary information to calculate a diversion detection of 0.36 per 100 beds pre-automation and 1.12 per 100 beds post-automation (P < 0.001). Out of the 19% of the institutions not using ACSCs, 60% provided the necessary information to calculate a diversion detection rate that was determined to be 0.76 per 100 beds. All respondents reported having policies and procedures related to the diversion of controlled substances; however, they varied significantly regarding drug screening practices and specific conditions for the rehire of staff that were detected diverting drugs. Conclusions When used properly, with effective checks and balances, ACSCs have the capability to improve detection of narcotic diversion; and thus, may help to decrease diversion of controlled substances by health care professionals.
Preventing Magnesium Toxicity in Obstetrics: Coumadin–Cardura Mix-Ups
Authors: Cohen Michael R. 
Published: December 2017

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them in your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the USP Medication Errors Reporting Program (MERP), which is presented in cooperation with the Institute for Safe Medication Practices. If you have encountered medication errors and would like to report them, you may call USP toll-free, 24 hours a day, at 800-233-7767 (800-23-ERROR). Any reports published by ISMP will be anonymous. Comments are also invited; the writers’ names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported through the ISMP ( www.ismp.org ) or USP ( www.usp.org ) Web sites or communicated directly to ISMP by calling 800-FAIL-SAFE or via E-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters’ wishes as to the level of detail included in publications.
Modafinil: Multiple Sclerosis-Related Fatigue
Authors: Generali Joyce , Cada Dennis J. 
Published: December 2017

Off-Label Drug Uses This Hospital Pharmacy feature is extracted from Off-Label DrugFacts, a quarterly publication available from Wolters Kluwer Health. Off-Label DrugFacts is a practitioner-oriented resource for information about specific FDA-unapproved drug uses. This new guide to the literature will enable the health care professional/clinician to quickly identify published studies on off-label uses and to determine if a specific use is rational in a patient care scenario. The most relevant data are provided in tabular form, so the reader can easily identify the scope of information available. A summary of the data—including background, study design, patient population, dosage information, therapy duration, results, safety, and therapeutic considerations—precedes each table of published studies. References direct the reader to the full literature for more comprehensive information prior to patient care decisions. Direct questions or comments on “Off-Label Drug Uses” to hospital pharmacy@drugfacts.com .
Sex differences and the influence of social factors in a Chilean urban psychiatric hospital population
Authors: Roselló Peñaloza Miguel , Gómez Fuentealba Pablo , Castillo Gallardo Patricia 
Published: December 2017

Background: The epidemiological literature has reported differences by sex in the prevalence of psychiatric diagnoses. However, we know little about how other socio-demographic factors participate in these differences. Aim: To identify the socio-demographic factors that correlate with prevalent psychiatric diagnoses in women and men in a Chilean urban psychiatric hospital population. Method: Socio-demographic information (age, educational level, marital status, family group and work status), psychiatric diagnoses and sex of the population were collected for 3,920 patients of a tertiary care hospital during a period of 8 years (2007–2014). The data were subjected to bivariate and multivariate analyses comparing the results by sex. Results: Among the most prevalent psychiatric diagnoses, those significantly correlated with sex were eating disorders and major depression (women) and schizophrenia (men). Socio-demographic factors behave differently in men and women regarding those diagnoses. Among the differences, working and being married correlated directly with the diagnosis of depression only among women. Living alone correlated directly with the diagnosis of schizophrenia among men, but correlated inversely among women. Conclusion: Dissimilar associations between sex, psychiatric diagnosis and socio-demographic factors found in this Latin American sample invite us to reflect on how social conditions crosscut the relation between sex and psychopathology and to include gender perspectives in psychiatric practices.
Strengths and virtues and the development of resilience: A qualitative study in Suriname during a time of economic crisis
Authors: Hendriks Tom , Graafsma Tobi , Hassankhan Aabidien , Bohlmeijer Ernst , de Jong Joop 
Published: December 2017

Background: Resilience can be described as the capacity to deal with adversity and traumatic events. The current economic situation in Suriname and its social economic consequences may demand a great amount of resilience for people living in Suriname. In this explorative study, we examined the relation between strengths and resilience among the three major ethnic groups in Suriname. Method: Semi-structured interviews were conducted with 25 participants. We sought to gather viewpoints from community representatives, health care professionals and academic scholars about the personal resources used by people in Suriname to help them deal with the consequences of the current socio-economic crisis. Results: We identified major five strengths that were associated with resilience: religiousness, hope, harmony, acceptance and perseverance. While these strengths contribute to the development of resilience, they can under certain circumstances have an ambiguous influence. Conclusion: Our findings suggest that religiousness is the bedrock strength for the development of resilience in Suriname. We recommend that future positive psychological interventions in non-Western countries integrate positive activities with religious elements into program interventions to achieve a better cultural fit.
Providers’ competencies positively affect personal recovery of involuntarily admitted patients with severe mental illness: A prospective observational study
Authors: Jas Ellen , Wieling Martijn 
Published: December 2017

Objective: There is limited research on the patient–provider relationship in inpatient settings. The purpose of this study was to measure the effect of mental healthcare providers’ recovery-promoting competencies on personal recovery in involuntarily admitted psychiatric patients with severe mental illness. Methods: In all, 127 Dutch patients suffering from a severe mental illness residing in a high-secure psychiatric hospital reported the degree of their personal recovery (translated Questionnaire about Processes of Recovery questionnaire (QPR)) and the degree of mental healthcare providers’ recovery-promoting competence (Recovery Promoting Relationship Scale (RPRS)) at two measurement points, 6 months apart. Analyses: (Mixed-effects) linear regression analysis was used to test the effect of providers’ recovery-promoting competence on personal recovery, while controlling for the following confounding variables: age, gender drug/alcohol problems, social relationships, activities of daily living, treatment motivation and medication adherence. Results: Analyses revealed a significant positive effect of providers’ recovery-promoting competencies on the degree of personal recovery ( t = 8.4, p < .001) and on the degree of change in personal recovery over time ( ts > 4, p < .001). Conclusion: This study shows that recovery-promoting competencies of mental healthcare providers are positively associated with (a change in) personal recovery of involuntarily admitted patients. Further research is necessary on how to organize recovery-oriented care in inpatient settings and how to enhance providers’ competencies in a sustainable way.
Role of rheology in tunning thermal conductivity of polyamide 12/polyamide 6 composites with a segregated multiwalled carbon nanotube network
Authors: Arboleda-Clemente Laura , García-Fonte Xoán , Abad María-José , Ares-Pernas Ana 
Published: December 2017

Effect of multiwalled carbon nanotubes in thermal conductivity of an immiscible blend of polyamides, 50/50 (wt%/wt%) polyamide 12/polyamide 6, was analyzed as function of nanofiller amount and temperature. Effect of the molding temperature in the structure of conductive network was investigated by rheology. Data show that 5 vol% multiwalled carbon nanotubes caused an increase of 41% in thermal diffusivity and 78% in thermal conductivity respect to polyamide blend values. Thermal conductivity improvement could be described by percolation theory, with a low threshold composition (φc = 0.09 vol% carbon nanotube). Fitting parameters obtained from Agari’s adjustment model show that polyamides structure is not affected by carbon nanotubes and the nanofillers can easily form conductive paths in the polyamide 12/polyamide 6 matrix. The temperature increase facilitates nanofiller dispersion causing the formation of a denser carbon nanotube network and rising the thermal diffusivity of carbon nanotube composites with low percolation level, as was proved on annealed samples at 255℃.
A feasibility randomized controlled trial of ReaDySpeech for people with dysarthria after stroke
Authors: Mitchell Claire , Bowen Audrey , Tyson Sarah , Conroy Paul 
Published: December 2017

Objective: To evaluate the feasibility of a multicentre randomized controlled trial of ReaDySpeech, an online speech therapy programme for people with dysarthria. Design: Feasibility randomized controlled trial, 2:1 minimization procedure. Setting: Four UK NHS services across hospital and community. Participants: Forty participants with dysarthria at least one week post-stroke. Interventions/comparator: ReaDySpeech with usual care ( n = 26) versus usual care only ( n = 14). Main outcomes: Feasibility measures included the following: recruitment and retention rate, time taken to carry out assessments, success of outcome assessor blinding, fidelity and adherence. Participant baseline and outcome measures collected before and after 8–10 weeks of intervention were the Frenchay Dysarthria Assessment II, Therapy Outcome Measure, Communication Outcomes After Stroke Scale, EQ-5D-5L and Dysarthria Impact Profile. Results: Recruited 40 participants out of 74 eligible people, 1–13 weeks post stroke and mean age 69 years (37–99). Retention was very high (92%). Assessor blinding was not achieved with intervention allocation correctly guessed for 70% of participants (26/37). Time to carry out assessments was acceptable to participants. ReaDySpeech was delivered to 16 of 26 allocated participants, who completed 55% of prescribed activities, but both interventions were delivered at low intensity (mean 6.6 face-to-face sessions of 40-minute duration). Conclusion: Recruitment and retention in this randomized controlled trial of computerized therapy for dysarthria is feasible for acute stroke. However, further feasibility work is needed to evaluate whether it is possible to recruit chronic stroke; increase intervention delivery, intensity and adherence; achieve outcome assessor blinding by video-recording and to determine sample size for a larger trial of effectiveness.
Efficacy and safety of multitarget therapy with cyclophosphamide and tacrolimus for lupus nephritis: a prospective, single-arm, single-centre, open label pilot study in Japan
Authors: Sakai R , Kurasawa T , Nishi E , Kondo T , Okada Y , Shibata A , Nishimura K , Chino K , Okuyama A , Takei H , Nagasawa H , Amano K 
Published: December 2017

Background Pulsed cyclophosphamide or mycophenolate mofetil for lupus nephritis has limited efficacy. We previously reported a case of mixed-class IV + V lupus nephritis successfully treated with cyclophosphamide and tacrolimus. This study assessed the efficacy and safety of multitarget therapy with cyclophosphamide and tacrolimus for the treatment of lupus nephritis. Methods In a prospective, single-arm, open label pilot study, we recruited 15 patients aged 18–64 years with active lupus nephritis who met the American College of Rheumatology criteria for a diagnosis of systemic lupus erythematosus (1997). The treatment protocol was a starting dose of prednisolone of 0.6−1.0 mg/kg/day for 2 weeks and then tapered to a maintenance dose, intravenous cyclophosphamide (500 mg biweekly for 3 months) and tacrolimus (3.0 mg/day). Tacrolimus was continued as maintenance therapy. Complete remission was defined as a spot urine protein/creatinine ratio of < 0.5 g/gCr with no active urine casts and a serum creatinine level that was either normal or within 30% of a previously abnormal baseline level. We retrospectively compared results for the study patients with those of 18 historical controls conventionally treated with cyclophosphamide and prednisolone. Results At baseline, the mean patient age was 41.5 ± 14.6 years (male:female ratio 2:13), urine protein/creatinine ratio 3.9 ± 2.3 g/gCr and serum creatinine 84.6 ± 34.6 µmol/L. Lupus nephritis classifications included classes IV ( n = 8), III + V ( n = 1), IV + V ( n = 5) and unclassified ( n = 1). Eleven patients completed the treatment protocol and four withdrew. At 6 months, 12 of 15 (80.0%) had achieved complete remission using intention-to-treat analysis, significantly more than historical controls (seven of 18 patients, 38.9%). A transient increase in serum creatinine and gastric symptoms occurred in three cases. One patient withdrew due to cytomegalovirus antigenemia and severe diabetes, and one patient died of thrombotic microangiopathy. Conclusions Multitarget therapy with cyclophosphamide and tacrolimus can be a therapeutic option for lupus nephritis. Clinical trials registration Combination therapy of tacrolimus and intravenous cyclophosphamide for remission induction of lupus nephritis, UMIN: 000004893, URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000005830&language=E . Date of registration: 18 January 2011.
A Second-Order Confirmatory Factor Analysis of the Moral Distress Scale-Revised for Nurses
Authors: Sharif Nia Hamid , Shafipour Vida , Allen Kelly-Ann , Heidari Mohammad Reza , Yazdani-Charati Jamshid , Zareiyan Armin 
Published: December 2017

Background: Moral distress is a growing problem for healthcare professionals that may lead to dissatisfaction, resignation, or occupational burnout if left unattended, and nurses experience different levels of this phenomenon. Objectives: This study aims to investigate the factor structure of the Persian version of the Moral Distress Scale–Revised in intensive care and general nurses. Research design: This methodological research was conducted with 771 nurses from eight hospitals in the Mazandaran Province of Iran in 2017. Participants completed the Moral Distress Scale–Revised, data collected, and factor structure assessed using the construct, convergent, and divergent validity methods. The reliability of the scale was assessed using internal consistency (Cronbach’s alpha, Theta, and McDonald’s omega coefficients) and construct reliability. Ethical considerations: This study was approved by the Ethics Committee of Mazandaran University of Medical Sciences. Findings: The exploratory factor analysis ( N = 380) showed that the Moral Distress Scale–Revised has five factors: lack of professional competence at work, ignoring ethical issues and patient conditions, futile care, carrying out the physician’s orders without question and unsafe care, and providing care under personal and organizational pressures, which explained 56.62% of the overall variance. The confirmatory factor analysis ( N = 391) supported the five-factor solution and the second-order latent factor model. The first-order model did not show a favorable convergent and divergent validity. Ultimately, the Moral Distress Scale–Revised was found to have a favorable internal consistency and construct reliability. Discussion and conclusion: The Moral Distress Scale–Revised was found to be a multidimensional construct. The data obtained confirmed the hypothesis of the factor structure model with a latent second-order variable. Since the convergent and divergent validity of the scale were not confirmed in this study, further assessment is necessary in future studies.