bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extortion experiences of recent adult immigrants from Latin America: self-reported prevalence, associated costs, and current mental health
Authors: Vargas Laura , Epperson C. Neill , Richmond Therese S. , Sharif Shadi , Berkowitz Lily , Giano Zachary , Hargarten Stephen , Ungar Mark , Weigend-Vargas Eugenio , Sakai Joseph 
Published: September 2024

AbstractViolence across Latin America is an increasingly important factor influencing migration to the US. A particular form of violence that is experienced by many Latinx migrants is extortion. This research analyzes the extortion experiences of Latinx immigrant adults arriving at the US southern border and the impact these experiences have on mental health. We find that on average, participants paid $804 in extortion during their migration. The most common perpetrators of extortion in our study were police followed by immigration officials throughout Latin America. Pregnant participants were less likely to experience extortion and adults traveling with children were more likely to be extorted. Participants who were extorted for money reported significantly greater severity of post-traumatic stress disorder (PTSD) symptoms compared to those who were not extorted. This research is the first of its kind to analyze extortion experiences among Latinx immigrants to the US, quantifying the prevalence, amounts paid, countries where extortion occurs, and perpetrators of extortion. In addition, extortion experiences are associated with negative effects on the mental health of newly arrived Latinx immigrants to the US. Based upon these findings, we recommend that extortion should be considered a significant stressor in the migrant experience, particularly for those adults traveling with children.
Community partnership approaches to safe sleep (CPASS) program evaluation
Authors: Lowell Gina S. , Sanford Jillian , Radecki Linda , Hanes Allison , Kozial Bonnie , Clark Felicia , McCain Jennifer , Abbasi Asim , Dalabih Sevilay , Hoffman Benjamin D. , Lee Lois K. 
Published: September 2024

Abstract
Background
Sudden unexpected infant death (SUID) continues to be a leading cause of death in infants in the United States (US), with significant disparities by race and socio-economic status. Infant safe sleep behaviors are associated with decreasing SUID risk, but challenges remain for families to practice these routinely. The objective of this program was to implement and evaluate a novel approach for an infant safe sleep pilot program built upon partnerships between hospitals and community-based organizations (CBOs) serving pregnant and parenting families in at-risk communities.

Methods
Community Partnership Approaches to Safe Sleep (CPASS) was a prospectively implemented infant safe sleep program. CPASS included children’s hospitals partnered with CBOs across five US cities: Portland, OR, Little Rock AR, Chicago, IL, Birmingham, AL, and Rochester, NY. The program consisted of (1) monthly learning community calls; (2) distribution of Safe Sleep Survival Kits; and (3) surveys of sites and families regarding program outcomes. Survey measures included (1) site participation in CPASS activities; (2) recipients’ use of Safe Sleep Kits; and (3) recipients’ safe sleep knowledge and behaviors.

Results
CPASS learning community activities were consistently attended by at least two representatives (1 hospital-based, 1 CBO-based) from each site. Across the five sites, 1002 safe kits were distributed over 9 months, the majority (> 85%) to families with infants ≤ 1 month old. Among participating families, 45% reported no safe sleep location before receipt of the kit. Family adherence to nighttime safe sleep recommendations included: (1) no bedsharing (M 6.0, SD 1.8, range 0–7); (2) sleep on back (M 6.3, SD 1.7, range 0–7); and (3) sleep in a crib with no blankets/toys (M 6.0, SD 2.0, range 0–7). Site interviews described how participation in CPASS influenced safe sleep conversations and incorporated local data into counseling. Hospital-CBO relationships were strengthened with program participation.

Conclusions
The CPASS pilot program provides a new, innovative model built on hospital-community partnerships for infant safe sleep promotion in SUID-impacted communities. CPASS reached families before their infant’s peak age risk for SUID and empowered families with knowledge and resources to practice infant safe sleep. Important lessons learned included improved ways to center and communicate with families.
Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism
Authors: Kant Ravi , Tilford Hannah , Freitas Camila S. , Ferreira Dayana A. Santos , Ng James , Rucinski Gwennan , Watkins Joshua , Pemberton Ryan , Abramyan Tigran M. , Contreras Stephanie C. , Vera Alejandra , Christodoulides Myron 
Published: September 2024

Abstract
Background
Neisseria gonorrhoeae (Ng) causes the sexually transmitted disease gonorrhoea. There are no vaccines and infections are treated principally with antibiotics. However, gonococci rapidly develop resistance to every antibiotic class used and there is a need for developing new antimicrobial treatments. In this study we focused on two gonococcal enzymes as potential antimicrobial targets, namely the serine protease L,D-carboxypeptidase LdcA (NgO1274/NEIS1546) and the lytic transglycosylase LtgD (NgO0626/NEIS1212). To identify compounds that could interact with these enzymes as potential antimicrobials, we used the AtomNet virtual high-throughput screening technology. We then did a computational modelling study to examine the interactions of the most bioactive compounds with their target enzymes. The identified compounds were tested against gonococci to determine minimum inhibitory and bactericidal concentrations (MIC/MBC), specificity, and compound toxicity in vitro.

Results
AtomNet identified 74 compounds that could potentially interact with Ng-LdcA and 84 compounds that could potentially interact with Ng-LtgD. Through MIC and MBC assays, we selected the three best performing compounds for both enzymes. Compound 16 was the most active against Ng-LdcA, with a MIC50 value < 1.56 µM and MBC50/90 values between 0.195 and 0.39 µM. In general, the Ng-LdcA compounds showed higher activity than the compounds directed against Ng-LtgD, of which compound 45 had MIC50 values of 1.56–3.125 µM and MBC50/90 values between 3.125 and 6.25 µM. The compounds were specific for gonococci and did not kill other bacteria. They were also non-toxic for human conjunctival epithelial cells as judged by a resazurin assay. To support our biological data, in-depth computational modelling study detailed the interactions of the compounds with their target enzymes. Protein models were generated in silico and validated, the active binding sites and amino acids involved elucidated, and the interactions of the compounds interacting with the enzymes visualised through molecular docking and Molecular Dynamics Simulations for 50 ns and Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA).

Conclusions
We have identified bioactive compounds that appear to target the N. gonorrhoeae LdcA and LtgD enzymes. By using a reductionist approach involving biological and computational data, we propose that compound Ng-LdcA-16 and Ng-LtgD-45 are promising anti-gonococcal compounds for further development.
Radiopharmaceutical small-scale preparation in Europe: will we be able to harmonize the situation?
Authors: Moya Estrella , Cerrato Celia , Bedoya Luis Miguel , Guerra José Antonio 
Published: September 2024

Abstract
Background
Radiopharmaceuticals have been considered a special group of medicines in Europe since 1989. The use of radiopharmaceuticals that have marketing authorization should always be the first option in clinical use, however due to their special properties the availability of approved radiopharmaceuticals is limited. For this reason, they can be produced on a small scale outside the marketing authorization process.

Main body
The in-house radiopharmaceutical preparations represent an important source of these special medicines for routine nuclear medicine practice. However, a lack of harmonization in Member States’ regulations leads to extreme differences in the use and availability of radiopharmaceuticals across Europe. The aim of this work is to provide an overview of the different national regulatory frameworks in which Directive 2001/83/UE is adopted on the preparation of radiopharmaceuticals outside the marketing authorization track in Europe. Nine different national regulations have been studied to describe how unlicensed radiopharmaceuticals are prepared. Special attention is paid to reflect the minimum standards that these preparations should meet as well as the educational requirements to be a radiopharmacist in charge of them.

Conclusion
The rapid development of new radiopharmaceuticals used in radiometabolic therapy requires a common regulation that allows balance between the use and preparation of licensed and unlicensed radiopharmaceuticals. The absence of a harmonized regulation for the radiopharmaceutical small-scale preparation and the implementation of Good Manufacture Practices, leads to extreme differences in the use, quality assurance and availability of radiopharmaceuticals in Europe.
Whether medicine supply is really meeting primary health care needs: a mixed-methods study in Shandong Province, China
Authors: Fan Zhixin , Gao Tiantian , Sun Qiang , Babar Zaheer-Ud-Din 
Published: September 2024

Abstract
Background
With the aging population, the increasing prevalence of chronic non-communicable diseases, and the diversified needs for primary health care (PHC) medicines, it is necessary to rethink the functional role of the supply of PHC medicines. This study aims to evaluate the supply of PHC medicines and the status of meeting PHC medicine needs.

Methods
The mixed-methods study was conducted to evaluate the supply of PHC medicines in Shandong Province. In the quantitative study, survey questionnaires were distributed to county hospitals, township hospitals, and patients, and a prescription review was performed in township hospitals. In the qualitative study, semi-structured interviews were conducted with the pharmacy managers, physicians, and patients in county hospitals, township hospitals, and village clinics. A senior pharmacist from a tertiary hospital who has rich experience on the indications for medicine use, accompanied us on a visit to inspect the PHC pharmacies to survey medicine equipment with a professional perspective.

Results
Quantitative analysis revealed that 211 county hospitals and 1,581 township hospitals participated in the survey, revealing the median annual frequency of medicine shortages of 5.0 times for county hospitals and 2.0 times for township hospitals. Of the 6,323 patient medication surveys, after excluding 152 patients not involved in medication use, 945 (15.3%) indicated medicine shortages, with half of these attributable to institutions lacking required medicines (52.8%). On average, the prescription qualified rate of 37 township hospitals was 72.2%. Four final themes emerged during the qualitative data analysis: (1) Supply of PHC medicines; (2) Solutions to the shortage of off-list medicines; (3) Appropriateness of PHC medicines list; (4) Pharmacist workforce development and pharmacy services.

Conclusions
The discrepancy between patients’ need for PHC medicine and present medicine supply is noteworthy. It is suggested that governments should optimize the existing lists to adequately meet patient medicine needs and prioritize medicines for chronic diseases, which is also particularly important for developing countries. Integrated health care may be a novel strategy to establish unified medicines list and achieve uniform pharmaceutical services in PHC.
Bacterial biodegradation of synthetic plastics: a review
Authors: Heris Yousef Sefidi 
Published: September 2024

Abstract
Background
Plastics are synthetic polymers that are reluctant to degradation. Therefore, their unlimited use has caused environmental problems. The reuse, reduce, and recycle methodology can solve these problems. However, this method is not efficient for mixed plastic wastes. As a result, more efficient and eco-friendly methods are necessary to remove these pollutants.

Main body of the abstract
Biodegradation is a more effective and operative method for resolving the global plastic waste problem. This method is defined as breaking down chemical compounds by the enzymes released by organisms. Bacteria are among the plastic-degrading organisms. Plastic biodegradation by bacteria occurs in four successive steps: biodeterioration, depolymerization, assimilation, and mineralization. Plastic biodegradation by these microorganisms includes different enzymatic reactions, converting synthetic plastics into simple mineral materials. These enzymes are part of metabolic pathways that use these polymers as primary substrates. Several factors, including the chemical structure of synthetic plastics, can affect their biodegradation efficacy.

Short conclusion
Although it is a promising solution for a global problem, bacterial biodegradation of synthetic plastics suffers from limitations such as slowness. The aim of the present study is to examine different aspects of bacterial biodegradation of synthetic plastics. These include the introduction of important plastic-degrading bacterial genera and enzymes involved in this biodegradation process. Additionally, metabolic pathways of synthetic plastic biodegradation, factors controlling this process, and limitations of this eco-friendly solution are examined.
On the effects of non-zero yaw on leading-edge tubercled wings
Authors: New T. H. , Mandrà S. 
Published: September 2024

AbstractSteady-state numerical simulations were conducted to capture the aerodynamic characteristics and flow patterns resulting from a tubercled and non-tubercled wing subjected to various combined pitch and yaw conditions at $$Re=1.8 \times 10^{5}$$

R
e
=
1.8
×

10
5

. Pitch angle ranged from $$0^{\circ }$$

0
∘

to $$25^{\circ }$$

25
∘

, while two different yaw angles of $$10^{\circ }$$

10
∘

and $$30^{\circ }$$

30
∘

were used. Results show that $$10^{\circ }$$

10
∘

yaw angle does not impact upon the lift and drag characteristics significantly, while a $$30^{\circ }$$

30
∘

yaw angle leads to substantial lift and drag losses. Additionally, the tubercled wing continues to confer favourable stall-mitigating characteristics even for the larger yaw angle. Finally, despite skewing the flow structures significantly, the $$30^{\circ }$$

30
∘

yaw angle also reduces the formations of bi-periodic flow structures, flow separations and recirculating regions along the leading-edge tubercles, suggesting potentially better flow stability and controllability.
Food additives and contaminants in infant foods: a critical review of their health risk, trends and recent developments
Authors: Soni Swati , W. Anvil Jennifer , Kurian Christine , Chakraborty Prapti , Paari Kuppusamy Alagesan 
Published: September 2024

AbstractThe infant food market has expanded rapidly over the past two decades. However, the industry faces significant challenges, including concerns over the health effects of infant food additives and issues with food safety. However, new evidences suggest that certain food additives, such as those used to preserve and transport infant formula to keep it fresh for longer, should be avoided. Science into the effects of additives on human behavior makes up a sizable sector of the additives market. Problems such as hypernatremic dehydration, malnutrition, and obesity in infants are directly linked to faulty formula production. The Food and Drug Administration (FDA) has established the toxicity types and chemical tests necessary for evaluating the safety of food additives and GRAS (Generally Recognized as Safe) compounds. These tests are crucial in understanding the food safety aspects of food additives. The health effects of different types of food additives on infants are discussed in this context. The article gives an outline of various national and global agencies that provides recommendations and standards to gauge the quality of baby food. The immunological responses, allergic reaction pathways and other related health hazards among the infants and young children caused by the food additive are discussed in this article.
Graphical Abstract
The sound heritage of Kotagede: the evolving soundscape of a living museum
Authors: Mediastika Christina E. , Sudarsono Anugrah S. , Utami Sentagi S. , Setiawan Teguh , Mansell James G. , Santosa Revianto B. , Wiratama Army , Yanti Ressy J. , Cliffe Laurence 
Published: September 2024

AbstractKotagede, the capital of the ancient Mataram Kingdom and currently an area in the Yogyakarta Province of Indonesia, is known as a ‘real living museum’. It was previously a residential area with many vital premises and heritage buildings that became a tourist area. Its locally established activities enrich the visual and sound environment of the vicinity. However, it has gradually lost its distinguishing sounds. A series of studies aims to improve the possibility of restoring past soundmarks to preserve the intangible heritage and make living museums as rich as possible. This paper reports the initial stage of the series, which focuses on capturing the rich historical sounds of Kotagede. The study was carefully designed to collect comprehensive data on heritage sounds using qualitative methods consisting of an initial focus group discussion (FGD), in-depth interviews, and a final FGD. These methods resulted in a large amount of data that were processed and classified using the descriptive phenomenology approach with the Colaizzi protocol. The study found that Kotagede has various soundmarks grouped into local and outside sounds. The locally rooted sounds can be grouped into eight categories, some of which can be extended as past and present sounds and a few that have persisted from the past to the present. In the subsequent stage, this classification and local leaders' concerns helped the researchers select and prioritise sounds for preservation and tourism purposes. The study emphasises the importance of choosing suitable participants to provide detailed and comprehensive information.
Regional impairment of left ventricular longitudinal strain in aortic regurgitation
Authors: Ferreira Joana , Marta Liliana , Presume João , Freitas Pedro , Guerreiro Sara , Abecasis João , Reis Carla , Ribeiras Regina , Mendes Miguel , Andrade Maria João 
Published: September 2024

Abstract
Background
Aortic regurgitation (AR) has an important impact on myocardial mechanics and recent studies have proved the value of global longitudinal strain (GLS) in the assessment of its severity and prognosis. Our purpose was to assess if the direct impact of the regurgitant jet on the myocardial wall could affect regional longitudinal strain.

Methods
Eighty patients with chronic moderate/severe AR were retrospectively studied. Patients were considered to have a jet-related longitudinal strain reduction when the myocardial segments directly impacted by the jet had their longitudinal strain reduced by at least 30% compared to nonaffected segments. AR severity, left ventricular (LV) size and function were compared according to the presence/absence of this regional pattern. For those who underwent surgery, postoperative regional and global LV function was also analyzed.

Results
A pattern of regional longitudinal strain impairment was identified in 43% of patients, with a regional reduction (in median) of 10 percentage points in absolute strain values in the segments impacted by the jet, compared to nonaffected segments. In the subgroup who underwent surgery, this pattern became attenuated after surgery. Patients with regional longitudinal strain impairment were less likely to improve GLS after surgery (10% vs. 38% improved GLS by at least 2.5%, P = 0.049).

Conclusions
To our knowledge, this study identifies for the first time, a link between the location of the impact of the regurgitant jet in AR and regional longitudinal strain impairment. The presence of this regional pattern might be associated with worse postoperative LV recovery.
Design and Evaluation of Inorganic/Organic Hybrid Bio-composite for Site-Specific Oral Delivery of Darifenacin
Authors: Ishaq Wafa , Afzal Attia , Farooq Muhammad , Sarfraz Muhammad , Adnan Sherjeel , Ahmed Hammad , Waqas Muhammad , Safdar Zainab 
Published: September 2024

AbstractBenign hyperplasia (BHP) is a common disorder that affects men over the age of 60 years. Transurethral resection of the prostate (TURP) is the gold standard for operative treatment, but a range of drugs are also available to improve quality of life and to reduce BHP-associated urinary tract infections and complications. Darifenacin, an anti-muscarinic agent, has been found effective for relieving symptoms of overactive bladder associated with BHP, but the drug has poor solubility and bioavailability, which are major challenges in product development. An inorganic/organic bio-composite with gastric pH-resistant property was synthesized for the targeted oral delivery of Darifenacin to the lower gastrointestinal tract (GIT). This development was accomplished through co-precipitation of calcium carbonate in quince seed-based mucilage. The FTIR, XRD, DSC, and TGA results showed good drug-polymer compatibility, and the SEM images showed calcite formation in the quince hydrogel system. After 72 h, the drug release of 34% and 75% were observed in acidic (0.1N HCl) and 6.8 pH phosphate buffer, respectively. A restricted/less drug was permeated through gastric membrane (21.8%) as compared to permeation through intestinal membrane (65%.) The developed composite showed significant reduction in testosterone-induced prostatic hyperplasia (2.39 ± 0.12***) as compared to untreated diseased animal group. No sign of organ toxicity was observed against all the developed composites. In this study, we developed an inorganic–organic composite system that is highly biocompatible and effective for targeting the lower GIT, thereby avoiding the first-pass metabolism of darifenacin.
Graphical Abstract