bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxide‐Bridged Mixed‐Valence Tetranuclear Cobalt 4‐Nitrophenol Inclusion Complex Showing Single Molecule Magnet Property
Authors: Shankar Krapa , Mondal Abhishake , Li Yanling , Journaux Yves , Baruah Jubaraj B. 
Published: September 2017

AbstractTwo tetranuclear hydroxide‐bridged mixed‐valence cobalt complexes, one having 4‐nitrophenolate anions and other having 4‐nitrophenol as guest, namely [(μ2‐dea)2(phen)2Co2(μ3‐OH)2Co2(phen)2](np)4•H2O (1), [(μ2‐dea)2(phen)2Co2(μ3‐OH)2 Co2(phen)2]Cl4•2Hnp•9H2O (2) (Hnp=4‐nitrophenol, phen=1,10‐phenanthroline, dea=di‐deprotonated diethanolamine) were synthesized and structurally characterized. Complex cation of these two complexes are based on Co4O4(OH)2 units where two cobalt ions are in Co2+ and other two are in Co3+ oxidation states. Reaction of same set of reactants namely phen, Hnp and diethanolamine with cobalt nitrate in presence or absence of hydrochloric acid resulted complex 1 and 2 respectively. The two triply‐bridging hydroxides of complex 1 are in identical environment, but the complex 2 has two triply‐bridging hydroxides in slightly different environments having differences in Co‐O(hydroxide) bond distances around them. Complex 2 is ferromagnetic and shows field induced Single Molecule Magnets (SMM) behavior.
Understanding Chemico‐Biological Interactions of Glutamate MMP‐2 Inhibitors through Rigorous Alignment‐Dependent 3D‐QSAR Analyses
Authors: Adhikari Nilanjan , Amin Sk Abdul , Saha Achintya , Jha Tarun 
Published: September 2017

AbstractThe current study involves different alignment techniques (pharmacophore‐based, docking‐based and Open3DALIGN‐based) extensively at the first time to build three‐dimensional quantitative structure‐activity relationship (3D‐QSAR) models on some potential glutamate‐based in house MMP‐2 inhibitors. The docking‐based alignment method yields the best 3D‐QSAR models though other alignment‐based methods also provide statistically significant and validated models. 3D‐QSAR models are correlated with molecular docking study and pharmacophore mapping. Biphenyl moiety of glutamines enters into the S1′ pocket and involves π‐π interactions with Tyr142 and His120, while none of the phenylacetyl/naphthylacetyl isoglutamines interacts with Tyr142. 3D‐QSAR models also suggest the importance of hydrophobicity and steric features of biphenyl function required for higher MMP‐2 inhibition. The sulfonyl oxygen may form potential hydrogen bonding interaction with Leu83 and Ala84 of S1' pocket. This study clearly points out that biphenylsulfonyl glutamines are favorable than phenylacetyl/naphthylacetyl isoglutamines for imparting higher MMP‐2 inhibition.
A Greener and Facile Synthesis of Imidazole and Dihydropyrimidine Derivatives under Solvent‐Free Condition Using Nature‐Derived Catalyst
Authors: Tamuli Kashyap Jyoti , Dutta Deepjyoti , Nath Shyamalendu , Bordoloi Manobjyoti 
Published: September 2017

AbstractNatural substances are increasingly used now‐a‐days in organic syntheses for their safety aspects towards the environment. We have identified a natural substance which can promote organic reaction and can be sustainable as it can be obtained from plant sources. The natural substance can promote the synthesis of imidazole and dihydropyrimidine derivatives under solvent‐free condition. The method is economical, greener, metal and solvent free for the synthesis of highly functionalized imidazole and dihydropyrimidine derivatives and was promoted by water extract of pomelo (WEP) at room temperature. These WEP promoted reactions are found to afford high yield for the desired products and can be an alternative protocol for the existing procedures.
Supramolecular Germicide Switches through Host‐Guest Interactions for Decelerating Emergence of Drug‐Resistant Pathogens
Authors: Bai Haotian , Fu Xuancheng , Huang Zehuan , Lv Fengting , Liu Libing , Zhang Xi , Wang Shu 
Published: September 2017

AbstractInfections caused by drug‐resistant pathogens have posed a series of public health crises across the world. To address this challenging issue, development of new antibiotics is one of the most effective methods, however it always lags behind the spreading of antibiotic resistance unfortunately. In this work we illustrate an innovative supramolecular strategy to design germicide switch for decelerating the emergence of drug‐resistant bacteria. The germicide switches are built up between commercial germicides and cucurbit[7]uril (CB[7]) through host‐guest interactions, and their bactericidal activity is switched “off” and “on” reversibly by assembly and dis‐assembly processes of germicide/CB[7] complex. Structure‐property relation exhibits that the interaction between active sites of germicides and CB[7] plays a decisive role in the antimicrobial activity of these germicide switches. By turning antibacterial activity “on” when needed and turning it “off” when not needed, the germicide switch will not continue to produce pressure on bacteria, thus decelerating the emergence of drug‐resistant bacteria. This work offers a proof‐of‐concept approach to efficiently prevent the emergence of drug‐resistant bacteria by controllable and reversible release and concealment of active sites of germicides by supramolecular strategy.
One Step Carbon‐Phosphor Bond Formation and N‐Alkylation of Tetrahydroisoquinolines under Silver Catalysis
Authors: Yi Fengping , Fan Yanxia , Zhang Lirong , Yi Weiyin 
Published: September 2017

AbstractHeterocycles with tetrahydroisoquinolines moiety are important biologically, and α‐aminophosphonates derivatives have unusual features in agrochemicals and medicines. In this paper, we combined these two parts to afford α‐aminophosphonates tetrahydroisoquinolines. A highly facile, one step direct carbon‐phosphor bond formation and N‐alkylation of tetrahydroisoquinolines was developed. It is a three‐component reaction of Nitrogen‐unprotected tetrahydroisoquinolines, aldehydes and trialkyl phosphites, which provides C1‐phosphonylated and N‐alkylation of THIQs (Tetrahydroisoquinolines) with moderate to high yields. The mild reaction conditions were investigated to give a broad range of substrates. Under the optimized reaction condition at reaction temperature 120 oC, after heating 8 h the desired final product was given in 90% yield, which is a satisfied reaction result. The different substituted benzaldehydes and THIQs were investigated in detail and proved to be broad. The proposed mechanism was also showed.
Hybrid Organic–Inorganic Perovskite Photodetectors
Authors: Tian Wei , Zhou Huanping , Li Liang 
Published: September 2017

AbstractHybrid organic–inorganic perovskite materials garner enormous attention for a wide range of optoelectronic devices. Due to their attractive optical and electrical properties including high optical absorption coefficient, high carrier mobility, and long carrier diffusion length, perovskites have opened up a great opportunity for high performance photodetectors. This review aims to give a comprehensive summary of the significant results on perovskite‐based photodetectors, focusing on the relationship among the perovskite structures, device configurations, and photodetecting performances. An introduction of recent progress in various perovskite structure‐based photodetectors is provided. The emphasis is placed on the correlation between the perovskite structure and the device performance. Next, recent developments of bandgap‐tunable perovskite and hybrid photodetectors built from perovskite heterostructures are highlighted. Then, effective approaches to enhance the stability of perovskite photodetector are presented, followed by the introduction of flexible and self‐powered perovskite photodetectors. Finally, a summary of the previous results is given, and the major challenges that need to be addressed in the future are outlined. A comprehensive summary of the research status on perovskite photodetectors is hoped to push forward the development of this field.
Photoactuation Healing of α‐FeOOH@g‐C3N4 Catalyst for Efficient and Stable Activation of Persulfate
Authors: Zhang Gong , Wu Zhang , Liu Huijuan , Ji Qinghua , Qu Jiuhui , Li Jinghong 
Published: September 2017

AbstractInspired by living systems, the construction of smart devices that can self‐heal in response to structural damage is a promising technology for maintaining the high activity and stability of catalysts during heterocatalytic reactions. Here this study demonstrates an ingenious platform that enabled efficient persulfate (PS) activation for contaminant degradation via integrating a catalyst with photoactuation regeneration. Under irradiation, it is unambiguously confirmed that the collective properties of a tailored FeOOH@C3N4 catalyst permit interfacial photoexcited electron transport from the photocatalyst substrate to needle‐shaped FeOOH. This results in the simultaneous recovery of Fe(III) and optimization of the Fe(II)/Fe(III) ratio on FeOOH surface during PS activation process, so that the healed chemical structure ensures that subsequent PS activation remains unimpaired. Aqueous organic contaminant (bisphenol A) oxidation efficacy in this system is almost 20 times higher than for photo‐ or Fenton‐oxidation alone. This work highlights the concept of catalyst regeneration for stable reactive species generation in solution, which represents alternative application of photocatalysis for practical environmental remediation. Further, the photoactuation healing approach can be expanded into various domains, such as material fabrication or chemical synthesis.
Low‐Cost TiS2 as Hole‐Transport Material for Perovskite Solar Cells
Authors: Huckaba Aron J. , Gharibzadeh Saba , Ralaiarisoa Maryline , Roldán‐Carmona Cristina , Mohammadian Nasim , Grancini Giulia , Lee Yonghui , Amsalem Patrick , Plichta Edward J. , Koch Norbert , Moshaii Ahmad , Nazeeruddin Mohammad Khaja 
Published: September 2017

AbstractA room‐temperature low‐cost TiS2 p‐type contact material is applied for the first time as the hole‐transporting material (HTM) in perovskite solar cells, with power conversion efficiencies surpassing 13.5%. Synthesized by a simple two‐step hot‐injection method, it presents a much lower price per m2 than octakis(4‐methoxyphenyl)‐9,9′‐spirospirobi[9H‐fluorene]‐2,2′,7,7′‐tetramine (spiro‐OMeTAD), 30 times lower in price ($0.046 for TiS2 and $1.36 for spiro‐OMeTAD at 13.54% efficiency), standing out over most of the reported HTM alternatives.
UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway
Authors: Mao Jiahui , Liang Zhaofeng , Zhang Bin , Yang Huan , Li Xia , Fu Hailong , Zhang Xu , Yan Yongmin , Xu Wenrong , Qian Hui 
Published: September 2017

Abstract
The deficiency or mutation of p53 has been linked to several types of cancers. The mesenchymal stem cell (MSC) is an important component in the tumor microenvironment, and exosomes secreted by MSCs can transfer bioactive molecules, including proteins and nucleic acid, to other cells in the tumor microenvironment to influence the progress of a tumor. However, whether the state of p53 in MSCs can impact the bioactive molecule secretion of exosomes to promote cancer progression and the regulatory mechanism remains elusive. Our study aimed to investigate the regulation of ubiquitin protein ligase E3 component n-recognin 2 (UBR2) enriched in exosomes secreted by p53 deficient mouse bone marrow MSC (p53–/–mBMMSC) in gastric cancer progression in vivo and in vitro. We found that the concentration of exosome was significantly higher in p53–/–mBMMSC than that in p53 wild-type mBMMSC (p53+/+mBMMSC). In particular, UBR2 was highly expressed in p53–/–mBMMSC cells and exosomes. P53–/–mBMMSC exosomes enriched UBR2 could be internalized into p53+/+mBMMSC and murine foregastric carcinoma (MFC) cells and induce the overexpression of UBR2 in these cells which elevated cell proliferation, migration, and the expression of stemness-related genes. Mechanistically, the downregulation of UBR2 in p53–/–mBMMSC exosomes could reverse these actions. Moreover, a majority of Wnt family members, β-catenin, and its downstream genes (CD44, CyclinD1, CyclinD3, and C-myc) were significantly decreased in MFC knockdown UBR2 and β-catenin depletion, an additional depletion of UBR2 had no significant difference in the expression of Nanog, OCT4, Vimentin, and E-cadherin. Taken together, our findings indicated that p53–/–mBMMSC exosomes could deliver UBR2 to target cells and promote gastric cancer growth and metastasis by regulating Wnt/β-catenin pathway.
Are Incidental Gallbladder Cancers Missed with a Selective Approach of Gallbladder Histology at Cholecystectomy?
Authors: Lundgren Linda , Muszynska Carolina , Ros Axel , Persson Gunnar , Gimm Oliver , Valter Lars , Andersson Bodil , Sandström Per 
Published: September 2017

AbstractBackgroundIncidental gallbladder cancer (IGBC) is an unexpected finding when a cholecystectomy is performed upon a benign indication, and the use of routine or selective histological analysis of gallbladder specimen is still debated. The aim of this study was to investigate whether the proportion of submitted gallbladder specimens for pathological investigation influences the proportion of IGBC found, and what possible factors preoperatively or perioperatively could influence the selection process.MethodsAll cholecystectomies between January 2007 and September 2014 registered in the Swedish Registry of Gallstone Surgery and ERCP (GallRiks) were included. Proportion of histological analysis was divided into four subgroups (0–25%, >25–50%, >50–75%, >75–100%).ResultsA total of 81,349 cholecystectomies were registered, and 36,010 (44.3%) gallbladder specimens were sent for histological analysis. A total of 213 cases of IGBC were discovered, which constituted 0.26% of all cholecystectomies performed and 0.59% of the number of gallbladder specimens sent for histological analysis. Hospitals submitting >75–100% of the gallbladder specimens had significantly more IGBC/1000 cholecystectomies performed (p = 0.003). Hospitals with the most selective approach had a significantly higher proportion of IGBC/1000 gallbladders that were sent for histological analysis (p < 0.001). Factors such as higher age (p < 0.001), female gender (p = 0.048) and macroscopic cholecystitis (p < 0.001) were more common in gallbladder specimens from hospitals that had a selective approach to histological analysis.ConclusionA routine approach to histological analysis in cholecystectomies with a benign indication for surgery can uncover a higher proportion of IGBC cases. When a selective approach is used, risk factors should be taken into account.
Liver involvement in urea cycle disorders: a review of the literature
Authors: Bigot Adrien , Tchan Michel C. , Thoreau Benjamin , Blasco Hélène , Maillot François 
Published: September 2017

AbstractUrea cycle disorders (UCDs) are inborn errors of metabolism of the nitrogen detoxification pathway and encompass six principal enzymatic deficiencies. The aging of UCD patients leads to a better knowledge of the long‐term natural history of the condition and to the reporting of previously unnoticed manifestations. Despite historical evidence of liver involvement in UCDs, little attention has been paid to this organ until recently. Hence, we reviewed the available scientific evidence on acute and chronic liver dysfunction and liver carcinogenesis in UCDs and discuss their pathophysiology. Overall, liver involvement, such as acute liver failure or steatotic‐like disease, which may evolve toward cirrhosis, has been reported in all six main UCDs. Excessive glycogen storage is also a prominent histologic feature, and hypoglycemia has been reported in citrin deficiency. Hepatocarcinomas seem frequent in some UCDs, such as in citrin deficiency, and can sometimes occur in non‐cirrhotic patients. UCDs may differ in liver involvement according to the enzymatic deficiency. Ornithine transcarbamylase deficiency may be associated more with acute liver failure and argininosuccinic aciduria with chronic liver failure and cirrhosis. Direct toxicity of metabolites, downstream metabolic deficiencies, impaired tricarboxylic acid cycle, oxidative stress, mitochondrial dysfunction, energy deficit, and putative toxicity of therapies combine in various ways to cause the different liver diseases reported.
What California sea lions exposed to domoic acid might teach us about autism: lessons for predictive and preventive medicine
Authors: Lahvis Garet Paul 
Published: September 2017

Abstract
Autism spectrum disorder (ASD) shares many biological and behavioral similarities with the deleterious effects of domoic acid (DA) exposure. DA is produced by marine algae and most commonly by species of Pseudo-nitzschia. Humans and marine mammals can be exposed to DA when they consume whole fish or shellfish. The mammalian fetus is highly sensitive to the deleterious effects of DA exposure. Both ASD and exposures to toxic levels of DA feature repetitive behaviors, challenges with social interaction, and seizures. They can also share a commonality in brain anatomy and function, particularly the balance between excitatory and inhibitory mechanisms. The current article is relevant to predictive, preventive, and personalized medicine for three reasons. First, shellfish consumption may be a risk factor for ASD and the regulatory limit for DA should be adjusted to prevent this possibility. Human contributions to increased algal production of DA in coastal waters should be identified and reduced. Second, evaluations of sentinel species wild and free-roaming in the environment, though typically outside the purview of biomedical research, should be much more fully employed to gain insights to risk factors for human disease. To better identify and prevent disease, biomedical researchers should study wild populations. Third, studies of DA exposure highlight the possibility that glutamate additives to processed foods may also have deleterious impacts on human brain development and behavior.
Love Death—A Retrospective and Prospective Follow-Up Mortality Study Over 45 Years
Authors: Lange Lena , Zedler Barbara , Verhoff Marcel A. , Parzeller Markus 
Published: September 2017

Abstract

Background
Although sexual activity can cause moderate stress, it can cause natural death in individuals with pre-existing illness. The aim of this study was to identify additional pre-existing health problems, sexual practices, and potential circumstances that may trigger fatal events.

Methods
This medicolegal postmortem, retrospective, and prospective study is based on data of autopsies performed at the Institute of Legal Medicine of the University hospital, Goethe-University, Frankfurt/Main, Germany.

Outcomes
Identification of pre-existing health problems, sexual practices, and potential circumstances than could trigger fatal events.

Results
From 1972 to 2016 (45 years) approximately 38,000 medicolegal autopsies were performed, of which 99 cases of natural death were connected to sexual activities (0.26%). Except for eight women, men represented most cases. The women’s mean age was 45 years (median = 45) and the men’s mean age was 57.2 years (median = 57). Causes of death were coronary heart disease (n = 28), myocardial infarction (n = 21) and reinfarction (n = 17), cerebral hemorrhage (n = 12), rupture of aortic aneurysms (n = 8), cardiomyopathy (n = 8), acute heart failure (n = 2), sudden cardiac arrest (n = 1), myocarditis (n = 1), and a combination of post myocardial infarction and cocaine intoxication (n = 1). Most cases showed increased heart weights and body mass indices. Death occurred mainly during the summer and spring and in the home of the deceased. If sexual partners were identified, 34 men died during or after sexual contact with a female prostitute, two cases at least two female prostitutes. Nine men died during or after sexual intercourse with their wife, in seven cases the sexual partner was a mistress, and in four cases the life partner. Five men died during homosexual contacts. Based on the situation 30 men were found in, death occurred during masturbation. Of the women, five died during intercourse with the life partner, two died during intercourse with a lover or friend, and in one case no information was provided.

Clinical Translation
Natural deaths connected with sexual activity appear to be associated with male sex and pre-existing cardiovascular disorders. Most cases recorded occurred with mistresses, prostitutes, or during masturbation. If death occurs, the spouse or life partner might need psychological support.

Strength and Limitations
To our knowledge, the present study contains the largest collection of postmortem data on natural deaths connected with sexual activities. However, the cases presented were of forensic interest; a larger number of undetected cases especially in the marital or stable relationship sector must be assumed.

Conclusion
Patients should be informed about the circumstances that could trigger the “love death.”
A cluster of patients with rhabdomyolysis after eating crayfish
Authors: Yang Wen-Xuan , Fan Kit-Ling , Leung Ling-Pong 
Published: September 2017

AbstractCrayfish or Procambarus clarkii is a freshwater crustacean with worldwide distribution. Tons of crayfish are consumed each year. In this report, four adult patients with rhabdomyolysis after consuming crayfish were described. All of them presented to the emergency department with myalgia. The diagnosis of rhabdomyolysis was supported by an elevated creatine kinase level. All recovered with supportive treatment. The clinical picture of these 4 patients was compatible with Haff disease. Haff disease is a syndrome in which rhabdomyolysis develops subsequent to consumption of certain cooked seafood. Crayfish is a common culprit. Diagnosis depends on obtaining a diet history and creatine kinase level. Most patients recover uneventfully with supportive treatment for rhabdomyolysis.
TEST VECTORS FOR LOCAL CUSPIDAL RANKIN–SELBERG INTEGRALS
Authors: KURINCZUK ROBERT , MATRINGE NADIR 
Published: September 2017

Let $\unicode[STIX]{x1D70B}_{1},\unicode[STIX]{x1D70B}_{2}$be a pair of cuspidal complex, or $\ell$-adic, representations of the general linear group of rank $n$over a nonarchimedean local field $F$of residual characteristic $p$, different to $\ell$. Whenever the local Rankin–Selberg $L$-factor $L(X,\unicode[STIX]{x1D70B}_{1},\unicode[STIX]{x1D70B}_{2})$is nontrivial, we exhibit explicit test vectors in the Whittaker models of $\unicode[STIX]{x1D70B}_{1}$and $\unicode[STIX]{x1D70B}_{2}$such that the local Rankin–Selberg integral associated to these vectors and to the characteristic function of $\mathfrak{o}_{F}^{n}$is equal to $L(X,\unicode[STIX]{x1D70B}_{1},\unicode[STIX]{x1D70B}_{2})$. As an application we prove that the $L$-factor of a pair of banal $\ell$-modular cuspidal representations is the reduction modulo $\ell$of the $L$-factor of any pair of $\ell$-adic lifts.