bluuebunny/crossref_metadata_2025_split huggingface dataset:
Education level is associated with the occurrence and timing of hysterectomy: A cohort study of Canadian women
Authors: Brennand Erin A. , Scime Natalie V. , Huang Beili , McDonagh Hull Pauline 
Published: September 2024

AbstractIntroductionHysterectomy is a common surgery with discernible practice variations that could be influenced by socioeconomic factors. We examined the association between level of educational attainment and the occurrence and timing of hysterectomy in Canadian women.Material and MethodsWe conducted a prospective cohort study of 30 496 females in the Alberta's Tomorrow Project (2000–2015) followed approximately every 4 years using self‐report questionnaires. Educational attainment was defined as high school diploma or less, college degree, university degree (reference group), and postgraduate degree. We used logistic regression analyzing hysterectomy occurrence at any time and before menopause, separately, and flexible parametric survival models analyzing hysterectomy timing with age as the time scale. Multivariable models controlled for race/ethnicity, rural/urban residence, parity, oral contraceptive use, and smoking.ResultsOverall, 39.1% of females reported a high school diploma or less, 28.9% reported a college degree, 23.5% reported a university degree, and 8.5% reported a postgraduate degree. A graded association was observed between lower education and higher odds of hysterectomy (high school or less: adjusted odds ratio [AOR] 1.68, 95% CI 1.55–1.82; college degree: AOR 1.58, 95% CI 1.45–1.72); results were similar for premenopausal hysterectomy. A graded association between lower education and earlier timing of hysterectomy was also observed up to approximately age 60 (eg at age 40: high school or less adjusted hazard ratio [AHR] 1.61, 95% CI 1.49–1.75; college degree AHR 1.53, 95% CI 1.40–1.67).ConclusionsWomen with lower levels of education were more likely to experience hysterectomy, including hysterectomy before menopause and at younger ages.
Editorial: Cardiometabolic criteria matters inMASLD
Authors: Teng Margaret L. P. , Muthiah Mark D. , Huang Daniel Q. 
Published: September 2024

LINKED CONTENTThis article is linked to Tamaki et al papers. To view these articles, visithttps://doi.org/10.1111/apt.18205andhttps://doi.org/10.1111/apt.18243
Letter: Potential impact ofHelicobacter pyloriinfection on oesophageal disorders in chronic liver disease—Authors' reply
Authors: Idalsoaga Francisco , Díaz Luis Antonio , Ayares Gustavo , Cabrera Daniel , Chahuan Javier , Monrroy Hugo , Halawi Houssam , Arrese Marco , Arab Juan Pablo 
Published: September 2024

LINKED CONTENTThis article is linked to Idalsoaga et al papers. To view these articles, visithttps://doi.org/10.1111/apt.18193andhttps://doi.org/10.1111/apt.18220
Use of, time to, and type of first add‐on anti‐hyperglycaemic therapy to metformin in Australia, 2018–2022
Authors: Milder Tamara Y. , Lin Jialing , Pearson Sallie‐Anne , Greenfield Jerry R. , Day Richard O. , Stocker Sophie L. , Neuen Brendon L. , Falster Michael O. , de Oliveira Costa Juliana 
Published: September 2024

AbstractAimsThe aim of this study was to examine contemporary trends in the use of, time to, and type of first add‐on anti‐hyperglycaemic therapy to metformin in Australia.MethodsWe used the dispensing records of a 10% random sample of Pharmaceutical Benefits Scheme (PBS) eligible people. We included people aged 40 years and older initiating metformin from 1 January 2018 to 31 December 2020. Our primary outcome was first add‐on anti‐hyperglycaemic medicine within 2 years of metformin initiation. We analysed time to dispensing of first add‐on therapy. All analyses were stratified by metformin initiation year.ResultsOverall, 38 747 people aged 40 years and older initiated metformin between 2018 and 2020. Approximately one‐third (n = 12 946) of people received add‐on therapy with the proportion increasing slightly by year of metformin initiation (32.3% in 2018 to 34.8% in 2020). Amongst people with add‐on therapy following metformin initiation, sodium‐glucose cotransporter 2 inhibitor (SGLT2i) use increased from 28.8% (2018) to 35.0% (2020), and glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) increased from 3.0% to 9.6%, respectively. Dipeptidyl peptidase‐4 inhibitors and sulfonylureas as first add‐on therapy decreased and insulin remained stable. One‐third of people with add‐on therapy initiated the therapy on the same day metformin was initiated, i.e. initial combination therapy.ConclusionsAmongst people initiating metformin from 2018 to 2020, there was an increasing proportion of SGLT2i and GLP‐1 RA being used as first add‐on therapy. However, the overall prevalence of add‐on therapy was low. Advocacy to promote add‐on therapy with cardiorenal beneficial medicines is critical to reduce type 2 diabetes morbidity and mortality.
Quantifying regulatory limits for multiple stressors in an open and transparent way
Authors: Stoffels Rick J. , White Richard S. A. 
Published: September 2024

AbstractBiodiversity is confronted globally by multiple stressors. Environmental policies must regulate these stressors to achieve targets, but how should that be done when the outcomes of limits on one stressor are contingent on other stressors, about which there is imperfect knowledge? Deriving regulatory frameworks that incorporate these contingencies is an emerging challenge at the science–policy interface. To be fit for implementation, these frameworks need to facilitate the inherently sociopolitical process of policy implementation and account transparently for uncertainty, such that practitioners and other stakeholders can more realistically anticipate the range of potential outcomes to policy. We developed an approach to quantify stressor limits that explicitly accounts for multistressor contingencies. Using an invertebrate data set collected over 30 years throughout New Zealand, we combined ecological and ecotoxicological models to predict biodiversity loss as a function of one stressor, treating multistressor contingencies as a form of uncertainty about the outcomes of limits on that stressor. We transparently accounted for that uncertainty by presenting regulatory limits as bands bounded between optimistic and pessimistic views that practitioners may have about the local context within which limits are applied. In addition to transparently accounting for uncertainties, our framework also leaves room for practitioners to build stakeholder consensus when refining limits to suit different local contexts. A criticism of this open, transparent approach is that it creates too much scope for choosing limits that are lenient on polluters, paralyzing on‐the‐ground management of multiple stressors, but we demonstrate that this is not necessarily the case.
BET inhibitors (BETi) influence oxidative phosphorylation metabolism by affecting mitochondrial dynamics leading to alterations in apoptotic pathways in triple‐negative breast cancer (TNBC) cells
Authors: Rossi Teresa , Iorio Egidio , Chirico Mattea , Pisanu Maria Elena , Amodio Nicola , Cantafio Maria Eugenia Gallo , Perrotta Ida , Colciaghi Francesca , Fiorillo Marco , Gianferrari Alessia , Puccio Noemi , Neri Antonino , Ciarrocchi Alessia , Pistoni Mariaelena 
Published: September 2024

AbstractRepressing BET proteins' function using bromodomain inhibitors (BETi) has been shown to elicit antitumor effects by regulating the transcription of genes downstream of BRD4. We previously showed that BETi promoted cell death of triple‐negative breast cancer (TNBC) cells. Here, we proved that BETi induce altered mitochondrial dynamics fitness in TNBC cells falling in cell death. We demonstrated that BETi treatment downregulated the expression of BCL‐2, and proteins involved in mitochondrial fission and increased fused mitochondria. Impaired mitochondrial fission affected oxidative phosphorylation (OXPHOS) inducing the expression of OXPHOS‐related genes, SDHa and ATP5a, and increased cell death. Consistently, the amount of mitochondrial DNA and mitochondrial membrane potential (∆Ψm) increased in BETi‐treated cells compared to control cells. Lastly, BETi in combination with Metformin reduced cell growth. Our results indicate that mitochondrial dynamics and OXPHOS metabolism support breast cancer proliferation and represent novel BETi downstream targets in TNBC cells.
Marandu palisade grass‐forage peanut mixed pastures: Forage intake, animal behaviour, and canopy structure as affected by grazing intensities
Authors: Rodrigues da Cruz Priscila Junia , Vieira da Silva Denise , de Lima Italo Braz Gonçalves , Alves Gustavo Campos , Homem Bruno Grossi Costa , Alves Bruno Jose Rodrigues , Boddey Robert Michael , Sbrissia Andre Fischer , Casagrande Daniel Rume 
Published: September 2024

AbstractIntegrating forage legumes into grasslands offers numerous ecosystem services. However, the management of grass‐legume pastures is challenging because the interaction between the defoliation frequency and severity may affect the legume persistence and forage intake by grazing animals. This 2‐year study evaluated the most effective grazing intensity to increase forage intake while maintaining a balanced legume proportion in tropical pastures consisting of Brachiaria brizantha and Arachis pintoi. Three treatments (grazing intensities) were assessed: severe, moderate, and low, corresponding to stubble heights of 10, 15, and 20 cm, respectively, and a pre‐grazing height of 25 cm. Two purebred Tabapua heifers were used for each treatment, and additional put‐and‐take animals were introduced, as required. Canopy structure, grazing behaviour, nutritive value, and forage intake were evaluated. The legume proportion in herbage mass remained consistent across all intensities, averaging 35% pre‐ and 32% post‐grazing. The grazing duration remained consistent across treatments on the first and third days, with an average grazing time of 390 and 440 min, respectively. Under post‐grazing conditions, low‐intensity grazing had a 52% greater intake rate than severe‐intensity grazing, which was attributed to a greater biting rate (37.9 bites/min) and bite weight (0.9 g DM/bite). Moderate grazing intensity (stubble height of ~15 cm associated with a pre‐grazing height of ~25 cm) is recommended to manage a mixture of B. brizantha and A. pintoi when the objective is to couple high forage intake with a balanced legume proportion in the pasture.
The impact of fear of attacks on pain‐related disability in cluster headache: Insights from the fear avoidance model
Authors: Fox Janosch , Gaul Charly , Slijepcevic Mirjana , Ohse Julia , Peperkorn Nicolina , Shiban Youssef 
Published: September 2024

AbstractObjectiveThis study utilized the theoretical framework of the “fear avoidance model” (FAM) and investigated the role of fear of attack in pain‐related disability. To this end, a measurement specific to cluster headache (CH) was used to investigate whether fear of attacks, alongside attack frequency, is a significant predictor of pain‐related disability in CH.BackgroundCluster headache substantially impacts daily functioning, yet empirical research exploring specific contributing factors is limited.MethodsA cross‐sectional online survey was undertaken in patients with CH, gathering sociodemographic, clinical data, and responses on the Cluster Headache Scale and the Depression, Anxiety and Stress Scale.ResultsAnalysis of data from 640 patients (chronic CH: 287/640 [44.8%]; female: 264/640 [41.3%]; male: 373/640 [58.3%]; gender diverse: three of 640 [0.5%]; age range: 18–86 years; mean [standard deviation] Cluster Headache Scales subscale disability score: 36.9 [9.8]; out of 869 respondents) revealed that both attack frequency and fear of attacks significantly predicted pain‐related disability (p < 0.001, percentage of variance explained: R2 = 0.24). More variance was explained by fear of attacks (R2 = 0.22) than by attack frequency (R2 = 0.02). This relationship remained significant even when controlling for depression and anxiety, which were also identified as independent predictors of pain‐related disability (p < 0.001, R2 = 0.44).ConclusionThis study emphasizes the relevance of psychological factors in CH‐related disability. Fear of attacks was found to be an independent predictor, while attack frequency was of minor relevance. Empirical investigation of the FAM in CH could improve the understanding of the mechanisms underlying disability and contribute to the development of CH‐specific interventions.
Patient Perceptions of Weight Stigma Experiences in Healthcare: A Qualitative Analysis
Authors: Robinson Kathleen M. , Robinson Kimberley A. , Scherer Aaron M. , Mackin Melissa Lehan 
Published: September 2024

ABSTRACTBackgroundWeight stigma is the social devaluation and denigration of individuals because of their excess body weight, resulting in poorer physical and mental health and healthcare avoidance. Attribution Theory and Goffman's theory of spoiled identity provided a general overarching framework for understanding weight stigma experiences.ObjectiveOur purpose was to explore weight stigma experiences from a broad range of perspectives emphasizing identities typically excluded in the weight stigma literature.DesignWe conducted a qualitative descriptive study with data drawn from 73 substantive narrative comments from participants who responded to a larger survey.ResultsAnalysis developed five themes: Working on weight, Not being overweight, Lack of help and empathy, Exposure and embarrassment and Positive experiences. Individuals who would be clinically assessed as overweight, especially men, often did not identify with having a weight problem and found the framing of personal responsibility for weight empowering. Participants with larger body sizes more often attributed embarrassment and shame about weight to treatment in the clinical setting. Older participants were more likely to have positive experiences.ConclusionsThe findings suggest ongoing tension between the framing of weight as a personal responsibility as opposed to a multifactorial condition with many uncontrollable aspects. Gender, age and body size shaped respondent perspectives, with some young male respondents finding empowerment through perceived personal control of weight. The healthcare system perpetuates weight stigma through lack of adequate equipment and excessively weight‐centric medical counselling. Recommending a healthy lifestyle to patients without support or personalized medical assessment may perpetuate weight stigma and associated detrimental health outcomes.Patient or Public ContributionPatients with obesity and overweight were integral to this study, providing comments for our qualitative analyses.
The Salience of Less Important Product Attributes
Authors: Park Jihye , Ko Dongwoo 
Published: September 2024

ABSTRACTThe significance of product attributes, as reflected in online reviews during the initial purchase, may undergo changes following positive or negative product usage experiences. The purpose of this research was to investigate whether positive or negative product consumption experiences influence shifts in the perceived importance of product attributes and subsequent product choices, based on online quality ratings by attributes. A series of experiments demonstrated that the importance associated with an attribute's expectation in the pre‐purchase process shifted after a negative consumption experience with that attribute. The results showed that a change in both attribute importance and product choice following a negative attribute experience. A less important attribute that malfunctioned during the consumption experience became more crucial in the subsequent purchase (Study 1). However, this shift in importance may not be universal for all attributes; it was observed only when the attribute was moderately important (Study 2). This study contributes valuable empirical findings to the existing literature on online reviews by highlighting dynamic shifts in the importance weight of product attributes. E‐commerce practitioners are encouraged to allow formal purchasers to leave product reviews without time constraints, providing a platform for reflecting users' lifelong consumption experiences.
Editor's highlights — October, 2024
Authors: Kemény Lajos 
Published: September 2024

AbstractDermatology has seen significant advancements in understanding and treating complex immune‐mediated chronic inflammatory skin conditions such as psoriasis and atopic dermatitis. This editorial highlights five pivotal studies that delve into the real‐world effectiveness of biological therapies and the challenges of treating pediatric patients with overlapping dermatological conditions. These studies collectively underscore the need for continued research and treatment approaches in dermatology.
Turpentine fruit paste as an ingredient of wheat bread: physicochemical and sensory properties
Authors: Qasem Akram A. , Mohamed Ahmed Isam A. , Mohammed Belal M. , Özcan Mehmet Musa , Albakry Zainab 
Published: September 2024

SummaryThe physical, chemical, phenolic constituents, fatty acids and mineral contents of the breads produced from wheat flour and turpentine paste at different concentrations were analysed by chromatographic and spectrophotometric methods. L*, a* and b* results of the breads were equal to 49.28–74.51, 0.90–6.55 and 13.45–20.19, respectively. Total phenolic and flavonoid quantities of the breads prepared by adding turpentine fruit paste at different concentrations were depicted to be between 26.15 (control) and 222.66 mg GAE/100 g (20%) to 74.52 (control) and 389.29 mg/100 g (20% turpentine fruit paste), respectively. Also, antioxidant activities of breads with turpentine paste were assigned to be between 2.44 (control) and 7.29 mmol kg−1 (20% turpentine paste). Gallic acid amounts of the breads were specified to be between 3.51 (control) and 16.98 mg/100 g (20% turpentine paste). Oleic and linoleic acid values of the bread oils were depicted to be between 45.34 (control) and 53.66% (3%) to 23.66 (3%) and 26.35% (control), respectively. K, P, S, Ca and Mg were the most abundant elements of bread samples. The changes in physical, chemical, phenolic components, fatty acids and mineral contents and sensory properties of the breads produced with turpentine paste added to wheat flour at different concentrations were determined.
Colorimetric loop‐mediated isothermal amplification (LAMP) for identification of crocodile meat in raw meat and commercial processed meat products
Authors: Thangsunan Pattanapong , Thangsunan Patcharapong , Uchuwittayakul Anurak , Suree Nuttee , Jakmunee Jaroon 
Published: September 2024

SummaryDeliberate and accidental adulteration or substitution of crocodile meat with other meats is possibly seen in meat products, which could be challenging to identify. This research aims to develop a new loop‐mediated isothermal amplification for accurately identifying crocodile meat in raw meat and processed food samples. Conditions for LAMP were initially optimised. The LAMP was proven for its high specificity to only crocodile DNA. The LAMP revealed a detection limit of 1 pg/μL crocodile DNA and 0.01% (w/w) crocodile meat in meat admixtures. From forty‐seven commercial processed meat samples, the LAMP detected crocodile content in ten products with the declaration of crocodile on their labels. Without the requirement of DNA purification, the direct LAMP showed its ability to detect crocodile content in both fresh meat and processed meat samples. This LAMP could become a promising alternative to support the food industry, especially for on‐site services and limited‐resource laboratories.
Curcumin‐loaded nanoparticles developed from sodium caseinate and OSA starch and the in vitro semi‐dynamic elderly digestion behaviour of fortified yogurt
Authors: Wang Ruijie , Deng Leiyu , Jin Weiping , Meng Qi , Han Jianzhong , Liu Weilin 
Published: September 2024

SummaryCurcumin is a bioactive substance, while poor stability and low bioavailability limit its effective utilisation. Curcumin‐loaded nanoparticles were prepared using the wall materials containing OSA starch alone (HI), sodium caseinate alone (SC), and a mixture of OSA starch and sodium caseinate (HS). Compared to HI and SC, HS had obvious network structure and smaller particle size, with the loading capacity higher than 20%. The storage stability at 4 °C were higher in HS and SC, FTIR and XRD results showed that all nanoparticles encapsulated curcumin through hydrogen bonding. When nanoparticles were added to yogurt, HI showed slower curcumin release during in vitro semi‐dynamic elderly digestion, whereas SC and HS can better accelerate the digestion rate of proteins in yogurt, leading to a decrease in the apparent viscosity of digestive emptying products. This study provided a reference for curcumin delivery wall materials and pushed forward development of functional foods for elderly.
Degradation of sesame hull pectin during roasting: catalytic effects of four inorganic chloride salts
Authors: Zheng Chuan‐Lei , Qin Zhi , Wang Kun‐Qi , Gao Tian‐Tian , Lu Hui‐Hui , Liu Xin‐Yao , Liu Hua‐Min , Wang Xue‐De , Wen Xin‐Yu , Zhang Hong‐Yu , Liu Hong‐Wei 
Published: September 2024

SummarySesame seed hull contains a substantial concentration of minerals. During the roasting, these minerals assume a catalytic function in the degradation of the sesame seed hull pectin. In this work, the effect of four inorganic chloride salts on the structure and thermal degradation products of sesame hull pectin during heating was investigated. The results indicated that, during roasting, chloride salts catalysed the degradation of pectin polysaccharide side chain regions more than the linear main chain. The introduction of chloride salts reduced the rate of mass loss from sesame hull pectin and resulted in a shift of the main peak towards a lower temperature range. The introduction of KCl and NaCl resulted in a significant decrease in the yield of furans and an increase in the proportion of small molecules such as acids and aldehydes in the thermal degradation products of sesame peel pectin, suggesting that the presence of KCl and NaCl facilitated the fragmentation of the sugar units. In contrast, MgCl2 and CaCl2 clearly facilitated the formation of furans and exhibited a discernible catalytic effect on the degradation of acidic substances. This study contributes to the understanding of the effect of minerals on the degradation behaviours of pectin in sesame hulls during sesame processing.
Shortbread cookies reformulation by raspberry powder enrichment: functional and sensory aspects
Authors: De Santis Diana , Ferri Serena , Rossi Alice , Frisoni Riccardo , Modesti Margherita 
Published: September 2024

SummaryThe consumer is looking for foods that can satisfy the need to combine nutrition and well‐being, not only balanced in their composition but also endowed with properties that can improve, or at least maintain, a good state of health. The study aims to enrich the short‐crust pastry with raspberry powder, as a base for breakfast biscuits, increasing its antioxidant properties. Optimising the extent of integration with raspberry powder helped avoid interference with the cross‐linking process of the gluten mesh. The reformulation of shortbread cookies was compared with that of non‐enriched biscuits to define chemical composition, antioxidant potential, and sensory profile. A consumer test helped to evaluate the acceptability of the new formulations. The results indicate that the integration with the optimal identified percentage of raspberry powder, by‐products of juice production, represents an excellent matrix to increase the health properties of shortbread cookies, improving functionality and sensory acceptability.