bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining drones and satellite tracking as an effective tool for informing policy change in riparian habitats: a proboscis monkey case study
Authors: Stark Danica J. , Vaughan Ian P. , Evans Luke J. , Kler Harjinder , Goossens Benoit 
Published: July 2017

AbstractRapid reaction times to undesirable events are becoming increasingly important for the protection and conservation of habitats and species. This study demonstrates how Unmanned Aerial Vehicles, or drones, and satellite tracking of individual animals can be combined to identify important conservation issues (e.g. deforestation). When quickly disseminated, the information can lead to a rapid change in conservation policy. An adult male proboscis monkey, belonging to a one‐male social group, wasGPStracked for 6 months in Sabah, Malaysian Borneo during 2012. Riparian habitats featured heavily (25.4% of total time, 88.6% of all sleeping sites) in the group's home range. A fixed‐wing drone was used in 2015 to map the habitat in high‐resolution. These data revealed that 47.54 ha of forest had been cleared shortly before the drone flights.GPStagging data revealed the importance of this area for a one‐male proboscis monkey group. A total of 30.1% of the proboscis monkeys' home range area had been cleared, as well as 11.4% of sleeping sites. Furthermore, drone images revealed that the felling extended to the river's edge, disregarding water resources laws requiring riparian reserves of a minimum of 20 m. Following this discovery, a press release including drone imagery combined withGPSdata, was published linking habitat destruction to a species that is economically important for the tourism industry in Sabah. The day following dissemination of the data, the Sabah State Government ordered an immediate cessation on further land clearing at sensitive riparian reserves along the river. We propose that this combination of satellite and aerial data provides potential for an effective conservation tool for endangered, iconic and economically important species. This visually compelling data, feasible over large spatial scales, can directly inform policy change in a quick and timely manner.
Physiological insights of recent clinical diagnostic and therapeutic technologies for cardiovascular diseases
Authors: Shigemi Kenji , Fuke Soichiro , Une Dai , Saku Keita , Shimizu Shuji , Kawada Toru , Shishido Toshiaki , Sunagawa Kenji , Sugimachi Masaru 
Published: July 2017

AbstractDiagnostic and therapeutic methods for cardiovascular diseases continue to be developed in the 21st century. Clinicians should consider the physiological characteristics of the cardiovascular system to ensure successful diagnosis and treatment. In this review, we focus on the roles of cardiovascular physiology in recent diagnostic and therapeutic technologies for cardiovascular diseases. In the first section, we discuss how to evaluate and utilize left ventricular arterial coupling in the clinical settings. In the second section, we review unique characteristics of pulmonary circulation in the diagnosis and treatment of pulmonary hypertension. In the third section, we discuss physiological and anatomical factors associated with graft patency after coronary artery bypass grafting. In the last section, we discuss the usefulness of mechanical ventricular unloading after acute myocardial infarction. Clinical development of diagnostic methods and therapies for cardiovascular diseases should be based on physiological insights of the cardiovascular system.
Education Gains Attributable to Fertility Decline: Patterns by Gender, Period, and Country in Latin America and Asia
Authors: Li Jing , Dow William H. , Rosero-Bixby Luis 
Published: July 2017

AbstractWe investigate the heterogeneity across countries and time in the relationship between mother’s fertility and children’s educational attainment—the quantity-quality (Q-Q) trade-off—by using census data from 17 countries in Asia and Latin America, with data from each country spanning multiple census years. For each country-year, we estimate micro-level instrumental variables models predicting secondary school attainment using number of siblings of the child, instrumented by the sex composition of the first two births in the family. We then analyze correlates of Q-Q trade-off patterns across countries. On average, one additional sibling in the family reduces the probability of secondary education by 6 percentage points for girls and 4 percentage points for boys. This Q-Q trade-off is significantly associated with the level of son preference, slightly decreasing over time and with fertility, but it does not significantly differ by educational level of the country.
Postmarital Living Arrangements in Historically Patrilocal Settings: Integrating Household Fission and Migration Perspectives
Authors: Pearlman Jessica , Pearce Lisa D. , Ghimire Dirgha J. , Bhandari Prem , Hargrove Taylor 
Published: July 2017

AbstractThis study integrates theory and research on household fission (or partition) and migration to better understand living arrangements following marriage, especially in historically patrilocal and primarily agricultural settings. Using panel data from the Chitwan Valley Family Study to analyze the sequential decision-making process that influences men’s living arrangements subsequent to first marriage, we demonstrate the importance of distinguishing among extended family living, temporary migration, and the establishment of an independent household. We find that community economic characteristics, such as access to markets or employment, as well as household wealth affect the initial decision to leave the natal home. Household resources and use of farmland, along with the young men’s own education, media exposure, travel, and marital behavior, influence the decision to make the departure from the natal home permanent. Our findings explain why previous results regarding household fission and those focused on migration have provided such mixed results, and we establish a new framework for thinking about how families and individuals manage living situations.
Relevance versus reliability of accounting information with unlimited and limited commitment
Authors: Schöndube-Pirchegger Barbara , Schöndube Jens Robert 
Published: July 2017

AbstractWe consider a two-period LEN-type agency problem. The principal needs to implement one out of two accounting systems. One emphasizes relevance, the other reliability. Both systems produce identical inter-temporally correlated signals. The relevant system reports an accounting signal in the period in which it is produced. The reliable system reports a more precise signal, but with a one period delay. Accounting information is contractible only if it is reported within the two-period horizon of the game. Accordingly, accounting information produced in the second period becomes uncontractible with the reliable system in place. Non-accounting information needs to be used for contracting to provide any second period incentives at all. We derive optimal compensation contracts in a full and in a limited commitment setting. With full commitment, the reliable system trades-off more precise first and less precise second-period contractible information, as compared to the relevant system. If the reduction of noise in the accounting signals is strong and the distortion in the non-accounting measure is weak, the reliable system is preferred. With limited commitment we identify a similar trade-off if intertemporal correlation of the signals is negative. If it is positive, this trade-off might reverse: The reliable system is possibly preferred if noise reduction is small and the non-accounting measure is heavily distorted. Noisiness in performance measures then serves as a commitment device. It reduces otherwise overly high powered incentives and thus benefits the principal.
Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health
Authors: Stephen Alison M. , Champ Martine M.-J. , Cloran Susan J. , Fleith Mathilde , van Lieshout Lilou , Mejborn Heddie , Burley Victoria J. 
Published: July 2017

AbstractResearch into the analysis, physical properties and health effects of dietary fibre has continued steadily over the last 40–50 years. From the knowledge gained, countries have developed guidelines for their populations on the optimal amount of fibre to be consumed each day. Food composition tables from many countries now contain values for the dietary fibre content of foods, and, from these, combined with dietary surveys, population intakes have been determined. The present review assessed the uniformity of the analytical methods used, health claims permitted, recommendations and intakes, particularly from national surveys across Europe and around the world. It also assessed current knowledge on health effects of dietary fibre and related the impact of different fibre types on health. The overall intent was to be able to provide more detailed guidance on the types of fibre which should be consumed for good health, rather than simply a total intake figure, the current situation. Analysis of data indicated a fair degree of uniformity in the definition of dietary fibre, the method used for analysis, the recommended amount to be consumed and a growing literature on effects on digestive health and disease risk. However, national dietary survey data showed that intakes do not reach recommendations and very few countries provide guidance on the types of fibre that are preferable to achieve recommended intakes. Research gaps were identified and ideas suggested to provide information for more detailed advice to the public about specific food sources that should be consumed to achieve health benefits.
Brain network dynamics in high-functioning individuals with autism
Authors: Watanabe Takamitsu , Rees Geraint 
Published: July 2017

AbstractTheoretically, autism should be underpinned by aberrant brain dynamics. However, how brain activity changes over time in individuals with autism spectrum disorder (ASD) remains unknown. Here we characterize brain dynamics in autism using an energy-landscape analysis applied to resting-state fMRI data. Whereas neurotypical brain activity frequently transits between two major brain states via an intermediate state, high-functioning adults with ASD show fewer neural transitions due to an unstable intermediate state, and these infrequent transitions predict the severity of autism. Moreover, in contrast to the controls whose IQ is correlated with the neural transition frequency, IQ scores of individuals with ASD are instead predicted by the stability of their brain dynamics. Finally, such brain–behaviour associations are related to functional segregation between brain networks. These findings suggest that atypical functional coordination in the brains of adults with ASD underpins overly stable neural dynamics, which supports both their ASD symptoms and cognitive abilities.
Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
Authors: Huang Lei , Pan Dongning , Chen Qingbo , Zhu Lihua J. , Ou Jianhong , Wabitsch Martin , Wang Yong-Xu 
Published: July 2017

AbstractBrowning of subcutaneous white fat (iWAT) involves several reprograming events, but the underlying mechanisms are incompletely understood. Here we show that the transcription factor Hlx is selectively expressed in brown adipose tissue (BAT) and iWAT, and is translationally upregulated by β3-adrenergic signaling-mediated suppression of the translational inhibitor 4E-BP1. Hlx interacts with and is co-activated by Prdm16 to control BAT-selective gene expression and mitochondrial biogenesis. Hlx heterozygous knockout mice have defects in brown-like adipocyte formation in iWAT, and develop glucose intolerance and high fat-induced hepatic steatosis. Conversely, transgenic expression of Hlx at a physiological level drives a full program of thermogenesis and converts iWAT to brown-like fat, which improves glucose homeostasis and prevents obesity and hepatic steatosis. The adipose remodeling phenotypes are recapitulated by fat-specific injection of Hlx knockdown and overexpression viruses, respectively. Our studies establish Hlx as a powerful regulator for systematic white adipose tissue browning and offer molecular insights into the underlying transcriptional mechanism.
A new energy transfer channel from carotenoids to chlorophylls in purple bacteria
Authors: Feng Jin , Tseng Chi-Wei , Chen Tingwei , Leng Xia , Yin Huabing , Cheng Yuan-Chung , Rohlfing Michael , Ma Yuchen 
Published: July 2017

AbstractIt is unclear whether there is an intermediate dark state between the S2 and S1 states of carotenoids. Previous two-dimensional electronic spectroscopy measurements support its existence and its involvement in the energy transfer from carotenoids to chlorophylls, but there is still considerable debate on the origin of this dark state and how it regulates the energy transfer process. Here we use ab initio calculations on excited-state dynamics and simulated two-dimensional electronic spectrum of carotenoids from purple bacteria to provide evidence supporting that the dark state may be assigned to a new Ag+ state. Our calculations also indicate that groups on the conjugation backbone of carotenoids may substantially affect the excited-state levels and the energy transfer process. These results contribute to a better understanding of carotenoid excited states.
Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease
Authors: Istas Geoffrey , Declerck Ken , Pudenz Maria , Szic Katarzyna Szarc vel , Lendinez-Tortajada Veronica , Leon-Latre Montserrat , Heyninck Karen , Haegeman Guy , Casasnovas Jose A. , Tellez-Plaza Maria , Gerhauser Clarissa , Heiss Christian , Rodriguez-Mateos Ana , Berghe Wim Vanden 
Published: July 2017

AbstractGenome-wide Illumina InfiniumMethylation 450 K DNA methylation analysis was performed on blood samples from clinical atherosclerosis patients (n = 8) and healthy donors (n = 8) in the LVAD study (NCT02174133, NCT01799005). Multiple differentially methylated regions (DMR) could be identified in atherosclerosis patients, related to epigenetic control of cell adhesion, chemotaxis, cytoskeletal reorganisations, cell proliferation, cell death, estrogen receptor pathways and phagocytic immune responses. Furthermore, a subset of 34 DMRs related to impaired oxidative stress, DNA repair, and inflammatory pathways could be replicated in an independent cohort study of donor-matched healthy and atherosclerotic human aorta tissue (n = 15) and human carotid plaque samples (n = 19). Upon integrated network analysis, BRCA1 and CRISP2 DMRs were identified as most central disease-associated DNA methylation biomarkers. Differentially methylated BRCA1 and CRISP2 regions were verified by MassARRAY Epityper and pyrosequencing assays and could be further replicated in blood, aorta tissue and carotid plaque material of atherosclerosis patients. Moreover, methylation changes at BRCA1 and CRISP2 specific CpG sites were consistently associated with subclinical atherosclerosis measures (coronary calcium score and carotid intima media thickness) in an independent sample cohort of middle-aged men with subclinical cardiovascular disease in the Aragon Workers’ Health Study (n = 24). Altogether, BRCA1 and CRISP2 DMRs hold promise as novel blood surrogate markers for early risk stratification and CVD prevention.
Ion Concentration Polarization by Bifurcated Current Path
Authors: Kim Junsuk , Cho Inhee , Lee Hyomin , Kim Sung Jae 
Published: July 2017

AbstractIon concentration polarization (ICP) is a fundamental electrokinetic process that occurs near a perm-selective membrane under dc bias. Overall process highly depends on the current transportation mechanisms such as electro-convection, surface conduction and diffusioosmosis and the fundamental characteristics can be significantly altered by external parameters, once the permselectivity was fixed. In this work, a new ICP device with a bifurcated current path as for the enhancement of the surface conduction was fabricated using a polymeric nanoporous material. It was protruded to the middle of a microchannel, while the material was exactly aligned at the interface between two microchannels in a conventional ICP device. Rigorous experiments revealed out that the propagation of ICP layer was initiated from the different locations of the protruded membrane according to the dominant current path which was determined by a bulk electrolyte concentration. Since the enhancement of surface conduction maintained the stability of ICP process, a strong electrokinetic flow associated with the amplified electric field inside ICP layer was significantly suppressed over the protruded membrane even at condensed limit. As a practical example of utilizing the protruded device, we successfully demonstrated a non-destructive micro/nanofluidic preconcentrator of fragile cellular species (i.e. red blood cells).
Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation
Authors: Jia Shuping , Rodriguez Miguel , Williams Arthur G. , Yuan Joseph P. 
Published: July 2017

AbstractThe molecular components of store-operated Ca2+ influx channels (SOCs) in proliferative and migratory vascular smooth muscle cells (VSMCs) are quite intricate with many channels contributing to SOCs. They include the Ca2+-selective Orai1 and members of the transient receptor potential canonical (TRPC) channels, which are activated by the endoplasmic reticulum Ca2+ sensor STIM1. The scaffolding protein Homer assembles SOC complexes, but its role in VSMCs is not well understood. Here, we asked whether these SOC components and Homer1 are present in the same complex in VSMCs and how Homer1 contributes to VSMC SOCs, proliferation, and migration leading to neointima formation. Homer1 expression levels are upregulated in balloon-injured vs. uninjured VSMCs. Coimmunoprecipitation assays revealed the presence and interaction of all SOC components in the injured VSMCs, where Homer1 interacts with Orai1 and various TRPC channels. Accordingly, knockdown of Homer1 in cultured VSMCs partially inhibited SOCs, VSMC migration, and VSMC proliferation. Neointimal area was reduced after treatment with an adeno-associated viral vector expressing a short hairpin RNA against Homer1 mRNA (AAV-shHomer1). These findings stress the role of multiple Ca2+ influx channels in VSMCs and are the first to show the role of Homer proteins in VSMCs and its importance in neointima formation.
SmMYB36, a Novel R2R3-MYB Transcription Factor, Enhances Tanshinone Accumulation and Decreases Phenolic Acid Content in Salvia miltiorrhiza Hairy Roots
Authors: Ding Kai , Pei Tianlin , Bai Zhengqing , Jia Yanyan , Ma Pengda , Liang Zongsuo 
Published: July 2017

AbstractPhenolic acids and tanshinones are two major bioactive components in Salvia miltiorrhiza Bunge. A novel endogenous R2R3-MYB transcription factor, SmMYB36, was identified in this research. This transcript factor can simultaneously influence the content of two types of components in SmMYB36 overexpression hairy roots. SmMYB36 was mainly localized in the nucleus of onion epidermis and it has transactivation activity. The overexpression of SmMYB36 promoted tanshinone accumulation but inhibited phenolic acid and flavonoid biosynthesis in Salvia miltiorrhiza hairy roots. The altered metabolite content was due to changed metabolic flow which was regulated by transcript expression of metabolic pathway genes. The gene transcription levels of the phenylpropanoid general pathway, tyrosine derived pathway, methylerythritol phosphate pathway and downstream tanshinone biosynthetic pathway changed significantly due to the overexpression of SmMYB36. The wide distribution of MYB binding elements (MBS, MRE, MBSI and MBSII) and electrophoretic mobility shift assay results indicated that SmMYB36 may be an effective tool to regulate metabolic flux shifts.
Heart rhythm characterization through induced physiological variables
Authors: Pons Jean-François , Haddi Zouhair , Deharo Jean-Claude , Charaï Ahmed , Bouchakour Rachid , Ouladsine Mustapha , Delliaux Stéphane 
Published: July 2017

AbstractAtrial fibrillation remains a major cause of morbi-mortality, making mass screening desirable and leading industry to actively develop devices devoted to automatic AF detection. Because there is a tendency toward mobile devices, there is a need for an accurate, rapid method for studying short inter-beat interval time series for real-time automatic medical monitoring. We report a new methodology to efficiently select highly discriminative variables between physiological states, here a normal sinus rhythm or atrial fibrillation. We generate induced variables using the first ten time derivatives of an RR interval time series and formally express a new multivariate metric quantifying their discriminative power to drive state variable selection. When combined with a simple classifier, this new methodology results in 99.9% classification accuracy for 1-min RR interval time series (n = 7,400), with heart rate accelerations and jerks being the most discriminant variables. We show that the RR interval time series can be drastically reduced from 60 s to 3 s, with a classification accuracy of 95.0%. We show that heart rhythm characterization is facilitated by induced variables using time derivatives, which is a generic methodology that is particularly suitable to real-time medical monitoring.
Effects of Aortic Valve Replacement on Severe Aortic Stenosis and Preserved Systolic Function: Systematic Review and Network Meta-analysis
Authors: Zheng Qishi , Djohan Andie H. , Lim Enghow , Ding Zee Pin , Ling Lieng H. , Shi Luming , Chan Edwin Shih-Yen , Chin Calvin Woon Loong 
Published: July 2017

AbstractThe survival benefits of aortic valve replacement (AVR) in the different flow-gradient states of severe aortic stenosis (AS) is not known. A comprehensive search in PubMed/MEDLINE, Embase, Cochrane Library, CNKI and OpenGrey were conducted to identify studies that investigated the prognosis of severe AS (effective orifice area ≤1.0 cm2) and left ventricular ejection fraction ≥50%. Severe AS was stratified by mean pressure gradient [threshold of 40 mmHg; high-gradient (HG) and low-gradient (LG)] and stroke volume index [threshold of 35 ml/m2; normal-flow (NL) and low-flow (LF)]. Network meta-analysis was conducted to assess all-cause mortality among each AS sub-type with rate ratio (RR) reported. The effects of AVR on prognosis were examined using network meta-regression. In the pooled analysis (15 studies and 9,737 patients), LF states (both HG and LG) were associated with increased mortality rate (LFLG: RR 1.88; 95% CI: 1.43-2.46; LFHG: RR: 1.77; 95% CI: 1.16-2.70) compared to moderate AS; and NF states in both HG and LG had similar prognosis as moderate AS (NFLG: RR 1.11; 95% CI: 0.81-1.53; NFHG: RR 1.16; 95% CI: 0.82-1.64). AVR conferred different survival benefits: it was most effective in NFHG (RR
with AVR
/RR
without AVR
: 0.43; 95% CI: 0.22-0.82) and least in LFLG (RR
with AVR
/RR
without AVR
: 1.19; 95% CI: 0.74-1.94).