bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three novel obese indicators perform better in monitoring management of metabolic syndrome in type 2 diabetes
Authors: Ma Chun-Ming , Lu Na , Wang Rui , Liu Xiao-Li , Lu Qiang , Yin Fu-Zai 
Published: August 2017

AbstractThe present study evaluated the performance of three novel obese indicators, visceral adiposity index (VAI), lipid accumulation product (LAP) and waist circumference-triglyceride index (WTI), for identifying metabolic syndrome(MetS) in type 2 diabetes. A cross-sectional study was conducted on 711 type 2 diabetes in Qinhuangdao. The MetS was defined as the definition of Chinese Diabetes Society. Receiver operating characteristic curve analyses were performed to assess the accuracy of three obese indicators as diagnostic tests for MetS. The prevalence of MetS was 71.3%. In men, among all three obese indicators, the LAP had the highest area under curve (AUC) value (AUC = 0.894), followed by VAI (AUC = 0.860) and WTI (AUC = 0.855). In women, among all three obese indicators, the LAP had the highest AUC value (AUC = 0.906), followed by WTI (AUC = 0.887) and VAI (AUC = 0.881). However. there was no significant difference between the three obese indicators(P > 0.05). Three obese indicators were effective indicators for the screening of MetS, LAP and WTI are more simple.
A reverse micelle strategy for fabricating magnetic lipase-immobilized nanoparticles with robust enzymatic activity
Authors: Yi Shixiong , Dai Fangyin , Zhao Cunyi , Si Yang 
Published: August 2017

AbstractEnzyme-immobilized nanoparticles that are both catalysis effective and recyclable would have wide applications ranging from bioengineering and food industry to environmental fields; however, creating such materials has proven extremely challenging. Herein, we present a scalable methodology to create Candida rugosa lipase-immobilized magnetic nanoparticles (L-MNPs) by the combination of nonionic reverse micelle method and Fe3O4 nanoparticles. Our approach causes the naturally abundant and sustainable Candida rugose lipase to ordered-assemble into nanoparticles with high catalytic activity and durability. The resultant L-MNPs exhibit the integrated properties of high porosity, large surface area, fractal dimension, robust enzymatic activity, good durability, and high magnetic saturation (59 emu g−1), which can effectively catalyze pentyl valerate esterification and be easily separated by an external magnet in 60 second. The fabrication of such fascinating L-MNPs may provide new insights for developing functional enzyme-immobilized materials towards various applications.
Dissecting the Molecular Mechanism of the Subcellular Localization and Cell-to-cell Movement of the Sugarcane mosaic virus P3N-PIPO
Authors: Cheng Guangyuan , Dong Meng , Xu Qian , Peng Lei , Yang Zongtao , Wei Taiyun , Xu Jingsheng 
Published: August 2017

AbstractThe coding sequence of P3N-PIPO was cloned by fusion PCR from Sugarcane mosaic virus (SCMV), a main causal agent of sugarcane (Saccharum spp. hybrid) mosaic disease. SCMV P3N-PIPO preferentially localized to the plasma membrane (PM) compared with the plasmodesmata (PD), as demonstrated by transient expression and plasmolysis assays in the leaf epidermal cells of Nicotiana benthamiana. The subcellular localization of the P3N-PIPO mutants P3N-PIPOT1 and P3N-PIPOT2 with 29 and 63 amino acids deleted from the C-terminus of PIPO, respectively, revealed that the 19 amino acids at the N-terminus of PIPO contributed to the PD localization. Interaction assays showed that the 63 amino acids at the C-terminus of PIPO determined the P3N-PIPO interaction with PM-associated Ca2+-binding protein 1, ScPCaP1, which was isolated from the SCMV-susceptible sugarcane cultivar Badila. Like wild-type P3N-PIPO, P3N-PIPOT1 and P3N-PIPOT2 could translocate to neighbouring cells and recruit the SCMV cylindrical inclusion protein to the PM. Thus, interactions with ScPCaP1 may contribute to, but not determine, SCMV Pm3N-PIPO’s localization to the PM or PD. These results also imply the existence of truncated P3N-PIPO in nature.
Phosphatidylinositol-3 Kinase Inhibitors, Buparlisib and Alpelisib, Sensitize Estrogen Receptor-positive Breast Cancer Cells to Tamoxifen
Authors: Chen I-Chun , Hsiao Li-Ping , Huang I-Wen , Yu Huei-Chieh , Yeh Ling-Chun , Lin Ching-Hung , Wei-Wu Chen Tom , Cheng Ann-Lii , Lu Yen-Shen 
Published: August 2017

AbstractTamoxifen is the standard first-line hormonal therapy for premenopausal women with estrogen receptor (ER)-positive metastatic breast cancer (BC). One of the crucial mechanisms underlying hormonal therapy resistance is the collateral activation of the phosphatidylinositol-3 kinase (PI3K)/AKT pathway. We explored whether PI3K inhibitors, buparlisib and alpelisib, enhance the efficacy of tamoxifen against ER-positive BC cells. We have observed a synergism between alpelisib or buparlisib and tamoxifen in the treatment for ER-positive BC cell lines harboring different PI3K alterations. Immunoblotting analysis showed alpelisib, buparlisib, or either drug in combination with tamoxifen downregulated the PI3K downstream targets in the MCF-7 and ZR75-1 cells. In the MCF-7 cells transfected with a constitutive active (myristoylated) AKT1 construct or mutant ER, the synergistic effect between alpelisib and tamoxifen was markedly attenuated, indicating that synergism depends on AKT inhibition or normally functioning ER. Combining alpelisib or buparlisib with tamoxifen also attenuated MCF-7 tumor growth in Balb/c nude mice. Our data suggest that additional PI3K blockade might be effective in enhancing the therapeutic effect of tamoxifen in ER-positive BC and support the rationale combination in clinical trials.
Proteomics analysis to reveal biological pathways and predictive proteins in the survival of high-grade serous ovarian cancer
Authors: Xie Hongyu , Wang Wenjie , Sun Fengyu , Deng Kui , Lu Xin , Liu Huijuan , Zhao Weiwei , Zhang Yuanyuan , Zhou Xiaohua , Li Kang , Hou Yan 
Published: August 2017

AbstractHigh-grade serous ovarian cancer (HGSC) is an aggressive cancer with a worse clinical outcome. Therefore, studies about the prognosis of HGSC may provide therapeutic avenues to improve patient outcomes. Since genome alteration are manifested at the protein level, we integrated protein and mRNA data of ovarian cancer from The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) and utilized the sparse overlapping group lasso (SOGL) method, a new mechanism-driven variable selection method, to select dysregulated pathways and crucial proteins related to the survival of HGSC. We found that biosynthesis of amino acids was the main biological pathway with the best predictive performance (AUC = 0.900). A panel of three proteins, namely EIF2B1, PRPS1L1 and MAPK13 were selected as potential predictive proteins and the risk score consisting of these three proteins has predictive performance for overall survival (OS) and progression free survival (PFS), with AUC of 0.976 and 0.932, respectively. Our study provides additional information for further mechanism and therapeutic avenues to improve patient outcomes in clinical practice.
Alpha-Glucan, Water Dikinase 1 Affects Starch Metabolism and Storage Root Growth in Cassava (Manihot esculenta Crantz)
Authors: Zhou Wenzhi , He Shutao , Naconsie Maliwan , Ma Qiuxiang , Zeeman Samuel C. , Gruissem Wilhelm , Zhang Peng 
Published: August 2017

AbstarctRegulation of storage root development by source strength remains largely unknown. The cassava storage root delay (srd) T-DNA mutant postpones storage root development but manifests normal foliage growth as wild-type plants. The SRD gene was identified as an orthologue of α-glucan, water dikinase 1 (GWD1), whose expression is regulated under conditions of light/dark cycles in leaves and is associated with storage root development. The GWD1-RNAi cassava plants showed both retarded plant and storage root growth, as a result of starch excess phenotypes with reduced photosynthetic capacity and decreased levels of soluble saccharides in their leaves. These leaves contained starch granules having greatly increased amylose content and type C semi-crystalline structures with increased short chains that suggested storage starch. In storage roots of GWD1-RNAi lines, maltose content was dramatically decreased and starches with much lower phosphorylation levels showed a drastically reduced β-amylolytic rate. These results suggested that GWD1 regulates transient starch morphogenesis and storage root growth by decreasing photo-assimilation partitioning from the source to the sink and by starch mobilization in root crops.
Hydrogen enhances strength and ductility of an equiatomic high-entropy alloy
Authors: Luo Hong , Li Zhiming , Raabe Dierk 
Published: August 2017

AbstractMetals are key materials for modern manufacturing and infrastructures as well as transpot and energy solutions owing to their strength and formability. These properties can severely deteriorate when they contain hydrogen, leading to unpredictable failure, an effect called hydrogen embrittlement. Here we report that hydrogen in an equiatomic CoCrFeMnNi high-entropy alloy (HEA) leads not to catastrophic weakening, but instead increases both, its strength and ductility. While HEAs originally aimed at entropy-driven phase stabilization, hydrogen blending acts opposite as it reduces phase stability. This effect, quantified by the alloy’s stacking fault energy, enables nanotwinning which increases the material’s work-hardening. These results turn a bane into a boon: hydrogen does not generally act as a harmful impurity, but can be utilized for tuning beneficial hardening mechanisms. This opens new pathways for the design of strong, ductile, and hydrogen tolerant materials.
The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond Functionalization
Authors: Besset Tatiana , Zhao Qun , Poisson Thomas , Pannecoucke Xavier 
Published: August 2017

In recent years, the C–H bond activation field has known very fast expansion offering valuable synthetic tools. Consequently, the quest for new approaches to afford atom- and step-economical processes has driven the scientific community to imagine original strategies. In this context, the direct functionalization of substrates by a transition-metal-catalyzed C–H bond activation using a transient directing group has emerged as a promising approach. This short review focuses on the major progress made in this field to provide to the reader an overview of the recent advances.1	Introduction2	From a Historical Point of View3	Functionalization of Carbonyl Derivatives4	Functionalization of Amines Derivatives5	Summary and Outlook
Endovascular Extraction of a Needle from the Internal Carotid Artery: A Novel Approach to a Controversial Dental Misadventure
Authors: Giurintano Jonathan , Somerville Jessica , Sebelik Merry , Hoit Daniel , Michael L. , Shires Courtney 
Published: August 2017

Objective To review the literature concerning the management of dental needles broken off into the deep spaces of the neck, to report what we believe is the first case of a fractured dental needle migrating into the jugular foramen, and the unconventional use of endovascular intervention to retrieve the needle fragment.
Design Case report with review of literature.
Setting Academic tertiary care center.
Participants Intervention was performed by the otolaryngology–head and neck surgery, vascular surgery, and neurovascular interventional radiology teams.
Results Transoral exploration, including palatal split and exposure of the poststyloid parapharyngeal space with C-arm image guidance, was unable to retrieve the broken needle, which traversed the internal carotid lumen with the distal end entering the jugular foramen. Through endovascular intervention, the neurovascular interventional radiology team captured the proximal end of the needle and retrieved it through the femoral artery. The patient recovered uneventfully.
Conclusion Fracture and loss of oral injection needles remain a persistent and preventable problem. This case demonstrates a novel, minimally invasive, well-tolerated, and successful method to extract a fractured needle that migrated into the lumen of the internal carotid artery at the level of the skull base.
Razonamiento Quirúrgico en Inestabilidad Crónica Posterolateral de Rodilla
Authors: Díaz Allende Pedro 
Published: August 2017

ResumenLos pacientes con mal alineamiento en varo pueden ser difíciles de tratar cuando tienen una lesión crónica de la esquina posterolateral (EPL), resultando en doble o triple varo y subsecuentemente varus thrust durante la marcha. Una osteotomía tibial alta es un procedimiento útil y necesario particularmente en el estadío crónico. Este artículo revisa los fundamentos de la planificación preoperatoria en una lesión crónica de la EPL.
Knowledge and Compliance in Practices in Diagnosis and Treatment of Syphilis in Maternity Hospitals in Teresina - PI, Brazil
Authors: Santos Raquel Rodrigues dos , Niquini Roberta Pereira , Domingues Rosa Maria Soares Madeira , Bastos Francisco Inácio 
Published: August 2017

Objective To assess the knowledge and compliance of health professionals regarding the diagnostic and treatment practices for syphilis in patients admitted for childbirth in public maternity hospitals in the city of Teresina, in the state of Piauí, Northeastern Brazil.
Methods A cross-sectional study was performed in 2015 with obstetricians and nurses working in the public maternity hospitals in Teresina (n = 159) using a self-administered questionnaire, with 5% of losses and 10% of refusals. The study used 21 evaluation criteria: 13 of them were related to knowledge (5 on serological tests and 8 on treatment adequacy); 8 were related to practices (3 on diagnosis, 4 on treatment, and 1 on post-test counseling). The knowledge of and compliance to the practices was estimated as the proportion of health professionals' answers that were in agreement with Brazilian Ministry of Health protocols.
Results The obstetricians were in agreement with two criteria concerning the knowledge of serological tests, one for diagnostic practices, and one for treatment practice. Among nurses, no single match between actual procedures and guidelines was observed.
Conclusions Low compliance with the protocols results in missed opportunities for the diagnosis and treatment of pregnant and postpartum women and their partners. Strategies for training and integrating the various professional groups, improved data recording on prenatal cards, and greater accountability of the hospital team in managing the women's partners are needed to overcome the barriers identified in the study and to interrupt the syphilis transmission chain.
Rotura espontánea del tendón extensor largo del pulgar – transferencia tendínea con técnica anestésica WALANT
Authors: Sanhueza Faúndez Miguel , Azócar Sanhueza Camila , Carrasco Penna Gabriel 
Published: August 2017

ResumenLa rotura espontanea del tendón extensor largo del pulgar (ELP), es una patología infrecuente existiendo casos reportados en la literatura donde no se logra encontrar factores predisponentes. El manejo quirúrgico suele realizarse utilizando una técnica de transposición tendínea del tendón del extensor propio del índice. En la actualidad, la técnica anestésica de WALANT “Wide Awake Local Anesthesia with No-Torniquet” ha sido de amplio desarrollo en la cirugía de la mano, sobre todo para la resolución quirúrgica de patología de tendones, con buenos y excelentes resultados. Se presenta un caso de un paciente con rotura espontánea del tendón ELP, que fue manejado con una transferencia tendínea utilizando la técnica anestésica WALANT.
Surgical Strategy for Dermoid and Epidermoid Tumors of the Posterior Fossa - Experience with 21 Patients
Authors: Lynch José , Welling Leonardo , Aversa Antonio , Esteves Celestino , Nogueira Jânio , Gonçalves Mariângela , Lopes Hélio 
Published: August 2017

Objective The aim of this paper is to describe our surgical strategy and technique and to identify the best management for posterior fossa dermoid and epidermoid tumors (PFDETs).
Methods We retrospectively identified 21 consecutive patients (11 males and 10 females), with a mean age of 33.2 years, a mean follow-up of 6.1 years, and pathologically confirmed PFDETs. Total 17 patients were submitted to the extended retrosigmoid approach. This approach incorporates transverse sigmoid sinus exposure and a generous mastoidectomy.
Results Gross total tumor removal was achieved in 16 (76.1%) cases, with no surgical mortality and a recurrence rate of 9.5%.
Conclusions The surgical strategies used in this group of patients enabled the total removal of most tumors without surgical mortality and with minimal morbidity and recurrence rates. The extended retrosigmoid approach used is an alternative path regarding cranial base approaches. This approach is quick, simple and safe, and decreases the retraction of the cerebellum.
Informieren, interpretieren, interagieren
Authors: Hillmer Lisa 
Published: August 2017

Zusammenfassung
Kommunikation im OP-Team Der Risikobereich OP wird oft mit einem
Flugzeug-Cockpit verglichen. Durch zahlreiche Studien ist bekannt, dass die
meisten Flugunfälle auf mangelhafte Kommunikation und Interaktion im Team
zurückzuführen sind 1 – das Gleiche gilt auch
für Fehler, die im OP passieren. Unsere Autorin hat untersucht, wodurch
Kommunikation im OP-Team beeinflusst wird und wie sie optimiert werden kann, um
Missverständnisse zu vermeiden.
Clinical Value of Contrast Enema Prior to Ileostomy Closure
Authors: Goetz Andrea , da Silva Natascha , Moser Christian , Agha Ayman , Dendl Lena-Marie , Stroszczynski Christian , Schreyer Andreas 
Published: August 2017

Purpose To determine the value of routine contrast enema of loop ileostomy before elective ileostomy closure regarding the influence on the clinical decision-making.
Materials and Methods Retrospective analysis of contrast enemas at a tertiary care center between 2005 und 2011. Patients were divided into two groups: Group I with ileostomy reversal, group II without ileostomy closure. Patient-related parameters (underlying disease, operation method) and parameters based on the findings (stenosis, leakage of anastomosis, incontinence) were evaluated.
Results Analyzing a total of 252 patients in 89 % (group I, n = 225) ileostomy closure was performed. In 15 % the radiologic report was the only diagnostic modality needed for therapy decision; in 36 % the contrast enema and one or more other diagnostic methods were decisive. In 36 % the radiological report of the contrast imaging was not relevant for decision at all. In 11 % (group II, n = 27) no ileostomy closure was performed. In this group in 11 % the radiological report of the contrast enema was the only decision factor for not performing the ileostomy reversal. In 26 % one or more examination was necessary. In 26 % the result of the contrast examination was not relevant.
Conclusion The radiologic contrast imaging of loop ileostomy solely plays a minor role in complex surgical decision-making before planned reversal, but is important as first imaging method in detecting complications and often leads to additional examinations.
Key points
Citation Format
Betriebliches Gesundheitsmanagement und Betriebsrat – Hürden und Potenziale in der
Zusammenarbeit mit Arbeitnehmervertretungen
Authors: Lange M. 
Published: August 2017

ZusammenfassungDer Erfolg von Maßnahmen im Rahmen des betrieblichen Gesundheitsmanagements ist stark von der
Zusammenarbeit verschiedener Interessenparteien wie die der Arbeitnehmer, der Arbeitgeber und der
Arbeitnehmervertretung geprägt. Die Rolle der Arbeitnehmervertretung gestaltet sich je nach Kontext
unterschiedlich und kann für eine erfolgreiche Umsetzung sowohl förderlich als auch hinderlich sein. Als
Grundlage für eine ergebnisorientierte Zusammenarbeit zwischen Arbeitgeber und Arbeitnehmervertretung
gelten verschiedene Gesetzesgrundlagen, die den Akteuren nur selten bekannt sind. Ziel dieses Beitrags
ist es, einen groben rechtlichen Rahmen im Kontext des betrieblichen Gesundheitsmanagements aufzuzeigen
und somit die Hürden und Potenziale in der Zusammenarbeit mit Arbeitnehmervertretungen zu optimieren. Die
Inhalte des Beitrags richten sich an betriebliche Gesundheitsberater, Arbeitnehmervertreter und andere
Interessierte.
Betriebliche Gesundheitskommunikation: Strategischer Einsatz von Kommunikationsinstrumenten
und Gesundheitsbrokern
Authors: Wäsche H. 
Published: August 2017

ZusammenfassungUm den Erfolg von Maßnahmen des Betrieblichen Gesundheitsmanagements zu gewährleisten, ist es notwendig,
gezielt Kommunikationsstrategien zu entwickeln, um weniger gesundheitsaffine und schwer erreichbare
Mitarbeiter zu erreichen. Im vorliegenden Beitrag wird ein systematischer Ansatz der Betrieblichen
Gesundheitskommunikation entworfen und die Rolle des Gesundheitsbrokers darin herausgearbeitet. Durch
eine Verknüpfung und Integration verschiedener Konzepte der Marketingkommunikation, des
Gesundheitsverhaltens sowie der Netzwerktheorie lässt sich ein umfassender und problembezogener Ansatz
der Strategieentwicklung in der Betrieblichen Gesundheitskommunikation konzipieren.
BGF im Kontext des Präventionsgesetzes – Herausforderungen an eine gesetzliche
Krankenkasse
Authors: Vockert T. 
Published: August 2017

ZusammenfassungIm Bereich der betrieblichen Gesundheitsförderung birgt das Präventionsgesetz Potenziale und
Herausforderungen für gesetzliche Krankenkassen. Im Sinne einer nachhaltigen
Gesundheitsförderung im Setting Betrieb können zukünftige Chancen darin liegen, sowohl
Angebote der teilweise in Konkurrenz stehenden Akteure zu verzahnen sowie bestehende
Strukturen der Lebenswelt übergreifend zu nutzen.
Wiederaufbau der Brust
Authors: Schwind Margot , Gonzalez-Heiberger Edgar 
Published: August 2017

Zusammenfassung
OP-Ablauf Nach einer Brustamputation besteht die Möglichkeit, mit einer
Aufbauplastik das äußere Erscheinungsbild der Patientin wiederherzustellen. Wir
haben dem Team des Leopoldina-Krankenhauses Schweinfurt bei der
skin-and-nipple-sparing Mastektomie mit implantatgestütztem Wiederaufbau über
die Schulter geschaut.
Chronifizierungsprophylaxe von Anfang an – Schmerzprogramme für Kinder
Authors: Steinberger Martin 
Published: August 2017

ZusammenfassungChronische Schmerzen bei Kindern und Jugendlichen können beträchtliche Auswirkungen auf die Lebensqualität der betroffenen Kinder und deren Familien haben. Inzwischen werden eine ganze Reihe von Therapiemaßnahmen unter dem Begriff „Schmerzprogramme“ angeboten, die von mehrwöchigen stationären Klinikaufenthalten bis hin zu eigenverantwortlich anwendbaren internetbasierten Trainings reichen. Bei chronischen Schmerzen haben sich auch bei Kindern intensive interdisziplinäre multimodale Therapieformen bewährt.
ADHS: Ursachen und Behandlungsmöglichkeiten
Authors: Ogal Mercedes 
Published: August 2017

ZusammenfassungDer Beitrag stellt den aktuellen Stand der möglichen Ursachen/Auslöser in Bezug auf ein primäres AD(H)S (ADHS=Aufmerksamkeitsdefizit-Hyperaktivitäts-Syndrom) dar. Die aktuellen Erkenntnisse sprechen für eine multifaktorielle Genese, ein komplexes, bisher wenig verstandenes Zusammenspiel aus neurobiologischen, genetischen, psychischen und sozialen Faktoren. Mehr oder weniger ausgeprägt spricht man von einer Funktionsstörung des Gehirns in den Bereichen Problemlösung, Planung und Impulskontrolle. Die Ursachen für ein sekundäres AD(H)S werden nur am Rande gestreift, da diese auf die persönlichen Lebensumstände des jeweiligen Kindes zurückzuführen sind.Verschiedene Behandlungsmöglichkeiten werden in Umgebungszentrierte und Kindzentrierte Interventionen gegliedert und vorgestellt. Anhand eines Fallbeispiels wird ein mögliches Vorgehen in der Praxis aufgezeigt.