bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Reactions of Carbonyl Compounds with Phosphorus Ylide Generated from Tribromofluoromethane and Tris(dimethylamino)phosphine.
Authors: Hirai Go , Nishizawa Eri , Kakumoto Daiki , Morita Masaki , Okada Mitsuaki , Hashizume Daisuke , Nagashima Sayoko , Sodeoka Mikiko 
Published: April 2016

AbstractReaction of the title ylide with simple aldehydes and ketones affords the expected Wittig products as mixtures of EIZ‐isomers.
ChemInform Abstract: Highly Regioselective Palladium‐Catalyzed Carboxylation of Allylic Alcohols with CO2.
Authors: Mita Tsuyoshi , Higuchi Yuki , Sato Yoshihiro 
Published: April 2016

AbstractAllylic alcohols are carboxylated in the presence of a catalytic amount of PdCl2 and PPh3 using stoichiometric ZnEt2 as transmetalation agent under CO2 atmosphere.
ChemInform Abstract: Palladium‐Catalyzed Benzylic C—H Arylation of Azaarylmethylamines.
Authors: Kim Byeong‐Seon , Jimenez Jacqueline , Gao Feng , Walsh Patrick J. 
Published: April 2016

AbstractAzaarylmethyl amines with cyclic or acyclic amino groups efficiently react with aryl and hetarylbromides or chlorides to form the corresponding aryl or hetaryl substituted azaarylmethylamines in high yields.
ChemInform Abstract: Selective Liquid‐Phase Hydrogenation of a Nitro Group in Substituted Nitrobenzenes over Au/Al2O3 Catalyst in a Packed‐Bed Flow Reactor.
Authors: Nuzhdin Alexey L. , Moroz Boris L. , Bukhtiyarova Galina A. , Reshetnikov Sergey I. , Pyrjaev Pavel A. , Aleksandrov Pavel V. , Bukhtiyarov Valerii I. 
Published: April 2016

AbstractNitrobenzenes are reduced to the corresponding anilines with nearly full conversion and excellent selectivities while reduction‐sensitive substituents (e.
ChemInform Abstract: Deep Eutectic Solvent Catalyzed Eco‐Friendly Synthesis of Imines and Hydrobenzamides.
Authors: Azizi Najmedin , Edrisi Mahtab 
Published: April 2016

AbstractImines (II) and hydrobenzamides (V) are synthesized using an urea—choline chloride‐based deep eutectic solvent as an efficient catalyst and reaction medium in good to high yields.
ChemInform Abstract: Unexpected Squaramide‐Induced Cleavage of Benzils: Synthesis and Characterization of Mono‐Aroyl Squarimides.
Authors: Sanna Elena , Lopez Carlos , Ballester Pablo , Rotger Carmen , Costa Antoni 
Published: April 2016

AbstractAn unprecedented cleavage of the inter‐carbonyl single bond of benzils is promoted by squaramide anions.
ChemInform Abstract: Indium‐Catalyzed Amide Allylation of N‐Carbonyl Imides: Formation of Azaspiro‐γ‐lactones via Ring Opening—Reclosure.
Authors: Sengoku Tetsuya , Murata Yusuke , Aso Yuwa , Kawakami Ai , Inuzuka Toshiyasu , Sakamoto Masami , Takahashi Masaki , Yoda Hidemi 
Published: April 2016

AbstractThe novel facile approach provides a new class of succinimide or phthalimide‐derived azaspiro‐γ‐lactones with an exo‐methylene lactam ring as potential drug candidates.
ChemInform Abstract: Stereo‐ and Chemodivergent NHC‐Promoted Functionalisation of Arylalkylketenes with Chloral.
Authors: Douglas James J. , Churchill Gwydion , Slawin Alexandra M. Z. , Fox David J. , Smith Andrew D. 
Published: April 2016

AbstractStereo‐ and chemodivergent enantioselective reaction pathways are observed upon treatment of alkylarylketenes and trichloroacetaldehyde (chloral) with N‐heterocyclic carbenes, giving selectively either β‐lactones or α‐chloro esters.
ChemInform Abstract: An Efficient One‐Pot Two Catalyst System in the Construction of 2‐Substituted Benzimidazoles: Synthesis of Benzimidazo[1,2‐c]quinazolines.
Authors: Cimarelli Cristina , Di Nicola Matteo , Diomedi Simone , Giovannini Riccardo , Hamprecht Dieter , Properzi Roberta , Sorana Federico , Marcantoni Enrico 
Published: April 2016

AbstractA Ce(III)/Cu(I)‐catalytic system mediates the reaction of aryl‐ and alkylaldehydes (I) and (IV) with o‐phenylenediamine (II) to the title compounds in good yields.
ChemInform Abstract: Iodine Mediated Synthesis of Coumarins from Chromenes.
Authors: Sharma Himanshu , Mourya Mohini , Soni Lokesh K. , Guin Debanjan , Joshi Yogesh C. , Dobhal Mahaveer P. , Basak Ashok K. 
Published: April 2016

AbstractThe presence of water is essential for the iodine‐mediated conversion of chromenes into coumarin derivatives.
ChemInform Abstract: Copper‐Promoted Tandem Reaction of Azobenzenes with Allyl Bromides via N=N Bond Cleavage for the Regioselective Synthesis of Quinolines.
Authors: Yi Xiangli , Xi Chanjuan 
Published: April 2016

AbstractOperationally simple conditions for the reaction of azobenzenes with allyl bromides to quinolines are reported which tolerate diversely substituted substrates.
ChemInform Abstract: Novel Exocyclic Enamides: Synthesis and Evaluation of the Fungicidal Activities of 5‐Methylene‐2‐(trifluoromethyl)morpholin‐3‐one Derivatives.
Authors: Tian Lei , Cui Can , Zhu Cong , Yang Hui‐Hui , Li Jian‐Qiang , Zhao Wei‐Guang 
Published: April 2016

AbstractThe novel exocyclic enamides are efficiently obtained by reaction of various trifluoroatrolactamides with propargyl bromide.
ChemInform Abstract: Organocatalytic Synthesis of Fused Bicyclic 2,3‐Dihydro‐1,3,4‐oxadiazoles Through an Intramolecular Cascade Cyclization.
Authors: Fugard Alison J. , Thompson Bethany K. , Slawin Alexandra M. Z. , Taylor James E. , Smith Andrew D. 
Published: April 2016

AbstractThe reaction tolerates various hydrazone‐carboxylic acid based substrates, and depending on the functional groups present the products are obtained in moderate to very high yields.
ChemInform Abstract: A Catalyst‐Free Synthesis of Phosphinic Amides Using O‐Benzoylhydroxylamines.
Authors: Zhu Rui , Pan Chongqing , Gu Zhenhua 
Published: April 2016

AbstractIn contrast to conventional methods the novel protocol tolerates a broad range of secondary phosphine oxides and O‐benzoylhydroxylamines while providing the products in moderate to very high yields.
ChemInform Abstract: New Acylated Flavonol Glycosides and a Phenolic Profile of Pritzelago alpina, a Forgotten Edible Alpine Plant
Authors: Corradi Elisabetta , De Mieri Maria , Cadisch Larissa , Abbet Christian , Hamburger Matthias , Potterat Olivier 
Published: April 2016

Abstractisolation and structure elucidation of eleven new acylated flavonoid glycosides from the aerial parts of Pritzelago alpina (Brassicaceae)
ChemInform Abstract: Eight New Alkaloids with PTP1B and α‐Glucosidase Inhibitory Activities from the Medicinal Mushroom Hericium erinaceus
Authors: Wang Kai , Bao Li , Ma Ke , Liu Ning , Huang Ying , Ren Jinwei , Wang Wenzhao , Liu Hongwei 
Published: April 2016

Abstractisolation and structure elucidation of erinacerin M (I), erinacerin N—P (II), erinacerin Q (III), erinacerin R (IV), erinacerin S (V), and erinacerin T (VI)
ChemInform Abstract: New 2‐Benzoxazolinone Derivatives with Cytotoxic Activities from the Roots of Acanthus ilicifolius.
Authors: Zhao Dan , Xie Lijun , Yu Lei , An Ni , Na Wei , Chen Feng , Li Youbin , Tan Yinfeng , Zhang Xiaopo 
Published: April 2016

AbstractFour new 2‐benzoxazolinone‐type alkaloids, acanthosides A—D, are isolated along with three known ones.
ChemInform Abstract: Silica Based Superhydrophobic Coating for Long‐Term Industrial and Domestic Applications.
Authors: Mahadik Satish A. , Pedraza Fernado , Vhatkar Rajiv S. 
Published: April 2016

AbstractA MeOH/H2O solution containing MeSi(O‐Et)3, HO2C‐CO2H, and NH3 is hydrolysized for 15 h at 20 °C before being sprayed on Ge, brass, steel, Cu, and glass substrates (2 min, 125 °C, 40% rel.
ChemInform Abstract: Towards High‐Efficiency Nanoelectrocatalysts for Oxygen Reduction Through Engineering Advanced Carbon Nanomaterials
Authors: Zhou Ming , Wang Hsing‐Lin , Guo Shaojun 
Published: April 2016

AbstractReview: recent developments of carbon‐based noble‐metal‐free high‐efficiency oxygen reduction electrocatalysts, including heteroatom‐doped, transition metal‐based nanoparticles, and especially iron carbide (Fe3C)‐based carbon nanomaterial composites; 295 refs.
ChemInform Abstract: Silica‐Supported Polyphosphoric Acid (PPA‐SiO2): An Efficient and Reusable Heterogeneous Catalyst for Ecofriendly Organic Synthesis
Authors: Vekariya Rajesh H. , Prajapati Neelam P. , Patel Hitesh D. 
Published: April 2016

AbstractReview: 130 refs.
ChemInform Abstract: To Rebound or Dissociate? This Is the Mechanistic Question in C—H Hydroxylation by Heme and Nonheme Metal—Oxo Complexes
Authors: Cho Kyung‐Bin , Hirao Hajime , Shaik Sason , Nam Wonwoo 
Published: April 2016

AbstractReview: review on hydroxylation reactions where dissociative non‐rebound mechanism is shown to dominate; 50 refs.
The challenge of being a young manager: The effects of contingent reward and participative leadership on team‐level turnover depend on leader age
Authors: Buengeler Claudia , Homan Astrid C. , Voelpel Sven C. 
Published: April 2016

SummaryEffective leadership requires a leaderclaimingas well as team membersgrantingthe leadership position. Contingent reward and participative leadership may both facilitate this mutual process. However, these behaviors differ in the degree to which they require a leader to have status and be prototypical. Their effectiveness might thus depend on the status‐related characteristics of the leader. In this respect, we propose that younger leaders, by deviating from the leader prototype in terms of age, lack a natural status cue, which will determine the effectiveness of these two leadership behaviors in shaping turnover. Two pilot studies (N = 113 and 121 individuals) confirm that younger leaders are perceived as less prototypical and to have lower status than older leaders. Examining 83 work teams, we show that leader age differently moderates the effects of contingent reward and participative leadership on time‐lagged team turnover. For younger (compared with older) leaders, contingent reward was effective as illustrated by decreased voluntary turnover and increased involuntary turnover, whereas participative leadership, which was associated with increased voluntary turnover and decreased involuntary turnover, was ineffective. These findings point to the importance of incorporating natural status cues of leaders for understanding the effectiveness of different leadership behaviors. Copyright © 2016 John Wiley & Sons, Ltd.
Tendon‐derived progenitor cells improve healing of collagenase‐induced flexor tendinitis
Authors: Durgam Sushmitha S. , Stewart Allison A. , Sivaguru Mayandi , Wagoner Johnson Amy J. , Stewart Matthew C. 
Published: April 2016

ABSTRACTTendinitis is a common and a performance‐limiting injury in athletes. This study describes the value of intralesional tendon‐derived progenitor cell (TDPC) injections in equine flexor tendinitis. Collagenase‐induced tendinitis was created in both front superficial digital flexor (SDF) tendons. Four weeks later, the forelimb tendon lesions were treated with 1 × 107autogenous TDPCs or saline. Tendinitis was also induced by collagenase in one hind SDF tendon, to study the survival and distribution of DiI‐labeled TDPCs 1, 2, 4, and 6 weeks after injection. The remaining normal tendon was used as a “control.” Twelve weeks after forelimb TDPC injections, tendons were harvested for assessment of matrix gene expression, biochemical, biomechanical, and histological characteristics. DiI‐labeled TDPCs were abundant 1 week after injection but gradually declined over time and were undetectable after 6 weeks. Twelve weeks after TDPC injection, collagens I and III, COMP and tenomodulin mRNA levels were similar (p = 0.3) in both TDPC and saline groups and higher (p < 0.05) than normal tendon. Yield and maximal stresses of the TDPC group were significantly greater (p = 0.005) than the saline group's and similar (p = 0.6) to normal tendon. However, the elastic modulus of the TDPC and saline groups were not significantly different (p = 0.32). Histological assessment of the repair tissues with Fourier transform‐second harmonic generation imaging demonstrated that collagen alignment was significantly better (p = 0.02) in TDPC group than in the saline controls. In summary, treating collagenase‐induced flexor tendon lesions with TDPCs improved the tensile strength and collagen fiber alignment of the repair tissue. Study Design © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:2162–2171, 2016.
NIPT and Informed Consent: an Assessment of Patient Understanding of a Negative NIPT Result
Authors: Piechan Julie L. , Hines Karrie A. , Koller Daniel L. , Stone Kristyne , Quaid Kimberly , Torres‐Martinez Wilfredo , Wilson Mathews Divya , Foroud Tatiana , Cook Lola 
Published: April 2016

AbstractSince becoming clinically available in 2011, the use of noninvasive prenatal testing (NIPT) to screen for fetal aneuploidy has continued to increase. However, it has been questioned whether the education of patients undergoing NIPT consistently meets informed consent standards. We sought to evaluate patients’ basic understanding of NIPT, such as conditions assessed and accuracy. In addition, we investigated patient self‐assessment of NIPT knowledge and satisfaction with the testing process. We distributed an anonymous paper survey to pregnant women during prenatal visits following a negative NIPT result. The survey assessed patient NIPT knowledge, gathered pregnancy‐specific and demographic information, and allowed respondents to rank their basic understanding of NIPT and provide written feedback about the testing process. A total of 95 completed and 3 partially completed surveys were returned. Participants scored lowest on knowledge questions involving whether a negative NIPT result ensures a healthy baby or eliminates the possibility of Down syndrome. Most perceived themselves to have a good basic understanding of NIPT and two‐thirds of the written feedback proposed no changes to NIPT administration. Overall, most patients appear satisfied with their understanding of NIPT and the testing process, yet they may not fully appreciate the limitations of this screening method.
Outcomes of Proximal Humerus Fracture Open Reduction Internal Fixation with Concomitant Ipsilateral Shoulder Girdle Injuries: A Case Control Study
Authors: Berkes Marschall B. , Little Milton T. M. , Pardee Nadine C. , Schottel Patrick C. , Lazaro Lionel E. , Lorich Dean G. 
Published: April 2016

Background Proximal humerus fractures treated in the face of ipsilateral injuries to the shoulder girdle may be predisposed to worse clinical outcomes. Questions/Purposes The purpose of this investigation was to examine outcomes of proximal humerus fractures treated with open reduction internal fixation (ORIF) using an endosteal augment in the presence of a concomitant shoulder girdle injury in comparison to isolated proximal humerus fractures treated with ORIF and endosteal augment. Methods A prospective database was used to identify proximal humerus fractures with ipsilateral shoulder girdle injuries (glenohumeral and acromioclavicular dislocation, fractures of the acromion, clavicle, scapula, or humeral diaphysis). These were compared to isolated proximal humerus fractures treated in the same fashion (ORIF with endosteal augment). Minimum of 1 year follow-up was required for inclusion. Outcomes assessed included range of motion (ROM), development of avascular necrosis (AVN), hardware-related complications, reoperation, and subjective outcome assessments including the Disabilities of Arm Shoulder and Hand questionnaire (DASH), Constant score, UCLA rating scale, and the Short Form-36 (SF-36). Results Fifteen ipsilateral injuries were seen in 14 patients. Seventy-seven isolated proximal humerus fractures were available for comparison. The ipsilateral injury group had significantly worse forward flexion (141 vs 156°, p = 0.02), external rotation (56 vs 64°, p = 0.03), higher rates of avascular necrosis (4 of 14, 28.6% vs 1 of 77, 1.3%, p = 0.002), and inferior SF-36 physical health scores (48.5 vs 63.5; p = .04). Despite these differences, no significant differences were seen with hardware-related complications or DASH, Constant score, or UCLA rating scale results. No patients required secondary reconstructive procedures. Conclusion Despite a statistically higher rate of AVN and decreased ROM, patient-based outcomes of proximal humerus fractures with ipsilateral shoulder injuries approached those seen in isolated proximal humerus fractures. This suggests that these injuries can achieve similarly good clinical results provided any associated shoulder pathology is identified and treated appropriately.
Dynamic Assessment of Functional Lipidomic Analysis in Human Urine
Authors: Rockwell Hannah E. , Gao Fei , Chen Emily Y. , McDaniel Justice , Sarangarajan Rangaprasad , Narain Niven R. , Kiebish Michael A. 
Published: April 2016

AbstractThe development of enabling mass spectrometry platforms for the quantification of diverse lipid species in human urine is of paramount importance for understanding metabolic homeostasis in normal and pathophysiological conditions. Urine represents a non‐invasive biofluid that can capture distinct differences in an individual's physiological status. However, currently there is a lack of quantitative workflows to engage in high throughput lipidomic analysis. This study describes the development of a MS/MSALL shotgun lipidomic workflow and a micro liquid chromatography–high resolution tandem mass spectrometry (LC–MS/MS) workflow for urine structural and mediator lipid analysis, respectively. This workflow was deployed to understand biofluid sample handling and collection, extraction efficiency, and natural human variation over time. Utilization of 0.5 mL of urine for structural lipidomic analysis resulted in reproducible quantification of more than 600 lipid molecular species from over 20 lipid classes. Analysis of 1 mL of urine routinely quantified in excess of 55 mediator lipid metabolites comprised of octadecanoids, eicosanoids, and docosanoids generated by lipoxygenase, cyclooxygenase, and cytochrome P450 activities. In summary, the high‐throughput functional lipidomics workflow described in this study demonstrates an impressive robustness and reproducibility that can be utilized for population health and precision medicine applications.
Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa
Authors: Mohiyuddin S.M. Azeem , Padiyar B. Vageesh , Suresh T.N. , Mohammadi Kouser , Sagayaraj A. , Merchant Shuaib , Sultana Azeem Mahnaaz 
Published: April 2016

AbstractObjectiveTo evaluate the margins of resected specimen of oral squamous cell carcinoma (SCC) and to document the surgical margin (measured at the time of resection) and margins at the time of pathological examination (after immersion of the specimen in formalin).MethodsPatients who were diagnosed and confirmed with squamous carcinoma of buccal mucosa were included in the study. Patients underwent resection of the tumor with a margin of 1 cm. Soon after resection, the distance between outermost visible margin of the tumor and the margin of the specimen was measured and documented. Specimens were fixed in 10% formalin and submitted for gross and histopathological examination. The closest histopathologic margin was compared with the in situ margin (10 mm) to determine and document any shrinkage of the margin and the percentage of discrepancy if any.ResultsA total of 52 specimens were collected from patients between January 2014 and December 2014. All specimens were obtained from the oral cavity (n = 52) of which 43 (82.7%) were squamous cell carcinoma and 9 (17.3%) were verrucous variant of squamous cell carcinoma. The average decrease in tumor margins measured after fixation in formalin was found to be statistically significant (P < 0.05) in 65% of cases.ConclusionTumor margin shrinks significantly after formalin fixation by about 25%. The operating surgeon and pathologist should be well aware of such changes while planning for further management thereby ensuring adequate margin of resection and adjuvant treatment wherever required to prevent possible local recurrence of the disease.
Subglacial processes on an Antarctic ice stream bed. 1: Sediment transport and bedform genesis inferred from marine geophysical data
Authors: LIVINGSTONE STEPHEN J. , STOKES CHRIS R. , Ó COFAIGH COLM , HILLENBRAND CLAUS-DIETER , VIELI ANDREAS , JAMIESON STEWART S. R. , SPAGNOLO MATTEO , DOWDESWELL JULIAN A. 
Published: April 2016

ABSTRACTThe spatial pattern and morphometry of bedforms and their relationship to sediment thickness have been analysed in the Marguerite Bay Palaeo-ice stream Trough, western Antarctic Peninsula. Over 17 000 glacial landforms were measured from geophysical datasets, and sediment thickness maps were generated from acoustic sub-bottom profiler data. These analyses reveal a complex bedform pattern characterised by considerable spatial diversity, influenced heavily by the underlying substrate. The variability in length and density of mega-scale lineations indicates an evolving bedform signature, whereby landforms are preserved at different stages of maturity. Lineation generation and attenuation is associated with regions of thick, soft till where deformation was likely to be the greatest. The distribution of soft till and the localised extent of grounding-zone wedges (GZWs) indicate a dynamic sedimentary system characterised by considerable spatio-temporal variability in sediment erosion, transport and deposition. Formation of GZWs on the outer shelf of Marguerite Trough, within the error range of the radiocarbon dates, requires large sediment fluxes (upwards of 1000 m3a−1(m grounding line width)−1), and a >1 m thick mobile till layer, or rapid basal sliding velocities (upwards of 6 km a−1).
A possiblePararcus diepenbroekivertebra from the Vossenveld Formation (Triassic, Anisian), Winterswijk, the Netherlands
Authors: During M.A.D. , Voeten D.F.A.E. , Schulp A.S. , Reumer J.W.F. 
Published: April 2016

AbstractAn isolated, completely ossified vertebra tentatively ascribed to the non-cyamodontid placodontPararcus diepenbroekiis described from the Anisian Vossenveld Formation in Winterswijk, the Netherlands, and compared to other material from the same locality. This fossil is the first completely ossified vertebra of the taxon and most likely originates from an adult specimen. It was recovered c. 16 m deeper in the stratigraphy than previously described material of the species, which is thus far known only from Winterswijk. Based on the slanting angle of the transverse process, the vertebra is interpreted to originate from the dorsal region. Besides the overall agreements in morphology that warrant a tentative identification asPararcus diepenbroeki, the newly described vertebra deviates from other knownPararcusvertebrae in the presence of a longer, well-ossified neural spine and a strongly constricted, less pachyostotic and ovaloid vertebral centrum. General agreement in morphology with previously described vertebrae suggests this novel condition indicates a different anatomical position and perhaps a varied ossification pattern.