bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of inflammatory markers in pathogenesis of venous thromboembolism
Authors: Cocoi Alexandra Florina , Pop Dana , Cocoi Mihai , Serban Adela Mihaela , Vida-Simiti Luminita Animarie 
Published: August 2017

Abstract
Inflammation of the venous wall is involved in thrombogenesis, thrombus resolution, wall remodeling and the post-thrombotic syndrome. Different mechanisms are involved in both arterial and venous thrombosis and patients with atherothrombosis hold a higher risk of venous thrombosis. Although inflammation may represent the connection between arterial and venous thrombosis, it is not yet sure if it is the cause or consequence of venous thrombosis. Consequently, the relationships between inflammation markers as indicators of the inflammatory process and clinical venous thromboembolism need to be investigatd. For example, inflammation mediators such as the pro-inflammatory cytokines interleukin 8 (IL-8), IL-6, monocyte chemotactic protein 1 (MCP-1), C Reactive Protein (CRP), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), matrix metalloproteinases and tumor necrosis factor alpha (TNF alpha) are all involved in thrombogenesis. Studies of venous thromboembolism on animal models proved that there are specific phases of the inflammatory process in venous thromboembolism and thrombus resolution. Knowing the molecular and immunologic mechanisms, identifying and understanding the inflammation markers which are relevant for venous thrombosis, can help to target specific pathways and to develop future therapies of this disease
Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis
Authors: Arghirescu Smaranda , Boia Eugen , Ursu Emilia , Savescu Delia , Boc Madalina , Jinca Cristian , Serban Margit 
Published: August 2017

Abstract
The adequate performance and correct interpretation of assays for coagulation factor inhibitors play a critical role for the hemostasis laboratory. Both, false positive and false negative inhibitor assays may be reported, leading to erroneous patient’s management. Therefore, we decided to present a case with a spurious image of an exceptionally rare acquired combined haemophilia A, B and C, with severe factor ( F) VIII, IX and XI deficiency, associated with high titre anti - F VIII, IX and XI inhibitors in a 4 years old girl with Henoch-Schönlein type vasculitis. Finally, performing, beside coagulometric methods also antigenic ELISA assays, we had to invalidate the diagnosis. The performance of antiphospholipd antibodies clarified the diagnosis , finally concluding as definite diagnosis Transient Lupus Anticoagulant Syndrome, with decisive impact on therapy and follow-up.
Stock Price Simulation Using Bootstrap and Monte Carlo
Authors: Pažický Martin 
Published: August 2017

Abstract
In this paper, an attempt is made to assessment and comparison of bootstrap experiment and Monte Carlo experiment for stock price simulation. Since the stock price evolution in the future is extremely important for the investors, there is the attempt to find the best method how to determine the future stock price of BNP Paribas′ bank. The aim of the paper is define the value of the European and Asian option on BNP Paribas′ stock at the maturity date. There are employed four different methods for the simulation. First method is bootstrap experiment with homoscedastic error term, second method is blocked bootstrap experiment with heteroscedastic error term, third method is Monte Carlo simulation with heteroscedastic error term and the last method is Monte Carlo simulation with homoscedastic error term. In the last method there is necessary to model the volatility using econometric GARCH model. The main purpose of the paper is to compare the mentioned methods and select the most reliable. The difference between classical European option and exotic Asian option based on the experiment results is the next aim of tis paper.
Primary Sources of Corporate Investment in Hungary
Authors: Katona Klára 
Published: August 2017

Abstract
This research aims to reveal how Hungarian companies have financed investments over the last two decades. Which financing strategy characterized them: was internal capital accumulation or external resources, such as bank loans or foreign capital the primary source of corporate investments? The study gives an overview of the conditions typical in the Hungarian financing and capital market over the last 25 years through an empirical analysis. Using a linear regression model, the paper examines the main investments sources among the top 5000 Hungarian firms according to revenues between 1996 and 2014. The model proved that the effect of loans in financing investments was significant and positive in all examined firms, independently from their ownership in the whole period. The rate of indebtedness of foreign companies was mainly attributable to local bank credits and not loans granted by mother companies.
Volatility Nexus Between Stock Market and Macroeconomic Variables in Bangladesh: an Extended GARCH Approach
Authors: Hasan Md. Abu , Zaman Anita 
Published: August 2017

Abstract
This paper examines the volatility of the Bangladesh stock market returns in response to the volatility of the macroeconomic variables employing monthly data of general index of Dhaka Stock Exchange (DSE) and four macroeconomic variables (Call Money Rate, Crude Oil Price, Exchange Rate and SENSEX of Bombay Stock Exchange) from January 2001 to December 2015. The results of GARCHS models reveal that the volatility of DSE return is significantly guided by the volatility of macroeconomic variables, such as, exchange rate and SENSEX. Specifically, volatility of the DSE is expected to 19% increase by 1% increase of exchange rate. Moreover, the volatility of the Bangladesh stock market returns is expected to dampen down by 2% with an increase in the volatility of Indian stock market of 1%. Thus, we can comment that adding exchange rate or stock returns of India in the GARCH model provides significant knowledge about the behaviour of the DSE volatility.
An Empirical Analysis of the Determinants of Economic Growth in the Western Balkans
Authors: Fetai Besnik Taip , Mustafi Besime Fekri , Fetai Ariana Besnik 
Published: August 2017

Abstract
The objective of this paper is to assess the main determinants and the policies that affect economic growth in the Western Balkan over the period 1994 to 2015. It employs techniques such as pooled OLS, fixed and random effects model, and Hausman-Taylor model with instrumental variables (IV). The study shows evidence of conditional convergence, indicating the need for an upward move in the steady state level. The results show that foreign direct investments, gross savings and domestic credit to the private sector have a positive effect on per capita growth. On the other hand, initial level of per capita growth, corruption, unemployment, and general government final consumption, have a negative relationship with per capita growth. The study also shows a puzzling result, that schooling is not a significant factor for growth in Western Balkans. The study also highlights the relevance of attracting more foreign direct investments and reduction in corruption.
Isolating of a putative glyceraldehyde-3 phosphate dehydrogenase (GAPDH) from Calophyllum brasiliense, an important tropical forest tree
Authors: Patreze C. M. , Felix D. B. , Scarano F. R. , Alves-Ferreira M. 
Published: August 2017

Abstract
Calophyllum brasiliense Cambess. has characteristics that made it an excellent candidate model for ecogenomics in rain forest trees such as widespread natural occurrence and geographical patterns of adaptive genetic variation. Besides, it is also becoming a popular species for reforestation efforts in Brazil. Although, very little is known about its genetic diversity and the molecular mechanisms involved genetic adaptation traits. The first difficulty in launching genetic studies in a wild wood species is the lack of an optimized protocol for RNA and DNA isolation. In this work we built the essential framework for molecular genetics research with C. brasiliense comparing four distinct methods of RNA extraction from of three different tissues: leaves, stems and roots. We also were successful in the isolation of genomic DNA by an optimized CTAB method. Finally, degenerated oligonucleotide primers were designed for isolating of the glyceraldehyde-3 phosphate dehydrogenase (GAPDH) gene of C. brasiliense from the corresponding gene in closely related species. This gene is commonly used in plants as reference in expression gene analysis by Reverse Transcription Polymerase Chain Reaction (RT-PCR). Primers for RT-PCR were designed based on partial sequence obtained using degenerate primers designed. The optimized methods of RNA and DNA extraction combined with the identification, isolation and specific primer design for RT-PCR of a traditional Reference Gene provide the essential framework for molecular genetics research with C. brasiliense.
Variation in Floral Phenological Synchronization in a Clonal Seed Orchard of Pinus tabuliformis in Northeast of China
Authors: Li Wei , Wang Xiaoru , Li Yue 
Published: August 2017

Abstract
Flowering phenology in an orchard is a crucial factor affecting the gene exchange among clones and consequently changing genetic composition of the seed crop. Pinus tabuliformis is now at the crucial period from first generation clonal seed orchards to advanced generation seed orchards in China. In this study, variation and stability in floral phenological synchronization of all the clones and possible mating pairs, in terms of an index of phenological overlap, were observed in a first generation clonal seed orchard which located in northeast of China. Results showed that significant variations occurred in the clones and mating pairs. This kind of variation was apparently related with temperature and humidity of the research site. With increasing age, levels of flowering synchronization were likely to rise in the clones and mating pairs. In general, the average flowering synchronization of male parents was slightly higher than that of female parents, female management in a seed orchard should be paied more attention. Flowering time was under strong genetic control and this genetic control was stronger in the female flowering process than of the males in terms of board sense heritability and year to year correlation analysis. Flowering synchronization of female parents was positively correlated between most years and can be a reliable reference for early and late predication in Pinus tabuliformis seed orchard during stage of initial seed harvest to stable seed production. According to their average levels of flowering synchronization, 49 clones in the first generation clonal seed orchard were divided into 11 different groups. Results of this paper provided the basic information for first generation seed orchard management and advanced seed orchard establishment of Pinus tabuliformis.
Optimisation of a multiplex PCR assay of nuclear microsatellite markers for population genetics and clone identification in Robinia pseudoacacia L.
Authors: Liesebach H. , Ewald E. 
Published: August 2017

Abstract
Black locust (Robinia pseudoacacia L.) is a tree species native to North America. The multipurpose tree is cultivated worldwide, but causes problems due to its partially invasive character. The application of nuclear microsatellite loci has many aims in population genetic studies. Here we introduce a very cost-effective method for combining the information of 14 nuclear microsatellite loci into two multiplex PCR sets as a contribution to greater standardisation and more comparable results. Combined non-exclusion probabilities for clone identification using example populations are estimated at between 1.37*E-5 and 1.67*E-11, and for paternity analysis for 1.59*E-4. The detected weak linkage between some microsatellite loci is not considered to be a substantial restriction to the reliability of the set of markers in providing an appropriate method for fingerprinting and parentage analysis.
Provenance Variation in Radial Increment and Wood Characteristics Revealed by 30 Years Old Norway Spruce Comparative Trials
Authors: Şofletea N. , Budeanu M. , Pârnuţă G. 
Published: August 2017

AbstractThe performance of 33 Norway spruce [Picea abies (L.) Karst.] seed sources from the Romanian Carpathians was evaluated with respect to growth and wood characteristics in comparative trials located at two different site conditions: Avrig- outside of the natural range of Norway spruce and Bret¸cu - within the natural range of this species. The radial increment (RI), latewood percentage (LWP) and conventional wood density (CWD) traits were evaluated at age 30 years after plantation. Phenotypic correlations between the evaluated traits, on the one hand, and between the same traits and the geographic gradients of the origin of seed sources, on the other hand, were calculated. Analysis of variance showed significant (p<0.01) differences between seed sources for RI, while for LWP and CWD, the differences were highly significant (p<0.001). These results suggest that selection at seed sources level could be possible. The test sites influence the LWP and CWD, while the RI is almost similar in both sites. For RI, the most valuable populations are situated in the Eastern and Western Romanian Carpathians. The highest LWP was registered for the Eastern Carpathian populations, while the lowest was recorded for the Western Carpathian populations. The Southern Carpathian populations, characterized by a lower growth rate, had higher values for wood density.
Early Selection for Improving Volume Growth in Coastal Douglas-fir Breeding Programs
Authors: Ye T. Z. , Jayawickrama K. J. S. 
Published: August 2017

AbstractMeasurements on growth traits up to 41 years of age from 68 progeny sites in eight first-generation breeding zones of coastal Douglas-fir (Pseudotsuga menziesii [MIRB.] FRANCO var. menziesii) in the US Pacific Northwest were used to investigate age trends of genetic parameters and to determine optimum age of selection. Heritabilities and age-age genetic correlations were estimated using univariate or bivariate mixed model analyses. Heritability estimates tended to increase with age for both total growth and growth increment traits. The estimates showed different age trends among breeding zones, but the differences were generally small. Age-age genetic correlations for total growth traits fitted Lambeth’s model surprisingly well, despite the data being collected from multiple breeding zones. Using rotation-age (i.e., 50yr) volume as the selection criterion, the greatest correlated gains per year were achieved by making family selection at juvenile ages (i.e., 9 for height, 13 for diameter, and 11 for volume). Similar results were obtained for within-family selection except that the optimum ages of selection were 2~4 years later than that from family selection, i.e., 11 for height, 15 for diameter and volume. Early selection on total height was always more efficient and had earlier optimum ages than on other growth traits. The optimum ages of early family selection on total growth were 4~11 years earlier than on the corresponding growth increment traits. It was also evident that the optimum ages of selection occurred later for slow-growth trials than for fast-growing trials.
Estimating coancestry within open-pollinated progenies of a dioecious species: the case study of Myracrodruon urundeuva
Authors: Moraes M. A. , Gaino A. P. S. , Moraes M. L. T. , Freitas M. L. M. , Sebbenn A. M. 
Published: August 2017

AbstractUnderstanding the coancestry coefficient within openpollinated progenies has long been an area of interest because of the implications of coancestry on estimates of additive genetic variation, variance effective size and the number of seed trees required for seed collection for ex situ conservation, tree breeding and environmental restoration. This study compares three methods to calculate the coancestry coefficient within open-pollinated progenies of the dioecious tree species, Myracrodruon urundeuva, using six microsatellite loci. The methods compared were: i) correlated mating model (CMM) (RITLAND, 1989); ii) TWOGENER method (SMOUSE et al., 2001) to estimate the differentiation among pollen pools (TGM); and iii) HARDY et al.’s 2004 method using the estimate of coancestry from LOISELLE et al. (1995) (HLM) and from RITLAND (1996) (HRM). The data analysis was based on four data sets: two populations were composed of 12 progenies, two of 24 progenies, and all progenies consisted of 15 plants. The coancestry estimated using CMM ranged among populations from 0.145 to 0.158, using TGM it ranged from 0.153 to 0.181, using HLM from 0.153 to 0.162, and HRM from 0.144 to 0.147. To investigate the bias of the estimates of true relatedness within progenies we simulated two half-sib and two full-sib populations. The most accurate method found in the study was CMM because the estimated values presented no bias for true half- or full-sib progenies and these values were very similar to those expected (0.125 and 0.25, respectively). These results have significant implications for breeding and conservation programs because coancestry-within-progenies is a key parameter in assessing the variance effective size.
Geomechanical Numerical Analysis as a Guidance for Preservation Works of the “Wieliczka” Salt Mine Site
Authors: D’Obyrn Kajetan , Tajduś Antoni 
Published: August 2017

Abstract
Salt was excavated at the “Wieliczka” Salt Mine for over 700 years. Underground mining operations terminated in 1996, by which time almost 2,400 chambers and 245 km of galleries had been created underground, situated on 9 levels and a few interlevels. In 1978, the mine was included in the UNESCO World Heritage List, which stated that parts of the mine with historical value had to be preserved for future generations. In order to preserve the most valuable chambers and galleries, activities aimed at establishing a protection pillar for excavations were conducted in the conservation area on Levels I-V. The need of large scope preserving works created the necessity to conduct a new and truly comprehensive geomechanical analysis. Such an analysis could only be done by means of advanced numerical modelling codes. Three-dimensional calculations were performed by means of FLAC 3D finite difference code. Rock mass stability assessment in the vicinity of excavations was carried out on the basis of the distribution and range of the so called failure zones. This comprehensive geomechanical analysis allows for verification and give the directions for future preservation and closure works in the “Wieliczka” mine.
Structural and Textural Characteristics of Selected Copper-Bearing Rocks as One of the Elements Aiding in the Assessment of Gasogeodynamic Hazard
Authors: Pajdak Anna , Kudasik Mateusz 
Published: August 2017

Abstract
The characteristics of copper-bearing rocks that include the structural and textural parameters are an important factor determining a possible gas accumulation in those rocks. In September 2009, in the Rudna copper mine in Poland, an outburst of gases and dolomite occurred. The analysis of the outburst mass showed that one of the main causes of the outburst was the different structural properties such as high porosity and presence of gas in the pores. This paper presents data from the structural analysis of dolomite from the Polkowice-Sieroszowice copper mine and the Rudna copper mine. Seven rock samples from various areas of the mines were tested by the following methods: mercury porosimetry (MIP), low pressure gas adsorption (LPNA), scanning electron microscopy (SEM), computed microtomography (micro-CT). The SEM analyses of the rock samples allowed pores of various sizes and shapes to the observed. The porosity (MIP) of the dolomite changed in the range of 3-15%. The total micro and mesopore volume (LPNA) was from 0.002 cm3/g to 0.005 cm3/g. The macropore volume (MIP) was from 0.01 cm3/g to 0.06 cm3/g and the mean macropore diameter was from 0.09 μm to 0.18 μm. The dolomite samples varied in the surface area (LPNA) (0.7-1.5 m2/g) and the pore distribution. The structure of dolomite determines the possibility of the occurrence of gasogeodynamic phenomena and hence it is urgent that research be conducted into its changeability. To better understand the gasogeodynamic processes in copper-bearing rocks, it is necessary to constantly monitor and analyse in detail those areas that have different structural properties.
Temperature Changes in the Vicinity of Thermally Loaded Structure Embedded in the Soil: Effect of Sand Content and Saturation Degree
Authors: Różański Adrian 
Published: August 2017

Abstract
Due to the rapid development of geothermal technologies, the problem of efficient and proper evaluation of soil thermal conductivity becomes extremely important. Factors mostly affecting the soil conductivity are the conductivity of solid phase and the degree of saturation. The former one is mainly affected by the mineral composition, in particular, by the content of quartz whose conductivity is the highest one among all the minerals forming soil skeleton. Organic matter, because of its relatively low conductivity, influences the solid conductivity as well. The problem addressed in the paper is the influence of mentioned factors on temperature changes in the vicinity of thermally loaded structure embedded in the soil medium. Numerical simulations are carried out for different values of soil thermal conductivity resulting from various quartz contents and degrees of saturation. In addition, a weak coupled - heat and water transport - problem is considered.
Functional Performance With Age: The Role of Long-Term Strength Training
Authors: Unhjem Runar , van den Hoven Lene T. , Nygård Mona , Hoff Jan , Wang Eivind 
Published: August 2017

Background and Purpose:
Physical function is shown to decline with age. However, how long-term strength training may attenuate the age-related limitation in functional tasks with various force demands is unclear.

Methods:
In a cross-sectional study, we assessed maximal muscle strength, initial and late phase rate of force development (RFD), as well as 4 tests of functional performance in 11 strength-trained master athletes (MAs), 11 recreationally active older adults (AEs), 10 sedentary older adults (SOAs), and 9 moderately active young controls. Functional performance was divided into 2 categories: more force-demanding (chair-rising ability and stair-climbing power) and less force-demanding (habitual walking speed and 1-leg standing) tasks.

Results:
MA exhibited 75%, 45%, and 26% higher leg press maximal strength compared with SOA, AE, and young, respectively (P < .01). MA leg press RFD was not different from young, but was higher compared to AE and SOA during both the initial (0-50 ms: 104%-177%, P < .05) and late phase (100-200 ms: 37%-52%, P < .05) of muscle contraction. MA also showed better mean (SD) performance compared with AE and SOA (P < .05) in more force-demanding functional tasks; chair-rising ability (MA: 6.2 (1.2) seconds; AE: 8.6 (1.8) seconds; SOA: 9.7 (3.0) seconds; young: 6.5 (1.0) seconds) and stair-climbing power (MA: 701 (161) W; AE: 556 (104) W; SOA: 495 (116) W; young: 878 (126) W). No differences (mean (SD)) were observed between MA and AE in less force-demanding tasks, but both groups were superior (P < .05) compared with SOA in walking speed (MA: 1.49 (0.21) m·s−1; AE: 1.56 (0.17) m·s−1; SOA: 1.27 (0.22) m·s−1; young: 1.62 (0.22) m·s−1) and balance test completion (MA: 45%; AE: 45%; SOA: 0%; young: 100%).

Conclusion:
Our results reveal that maintaining a high muscle force–generating capacity into older age is related to beneficial effects on functional performance, which may not be achieved with recreational activity, thus highlighting strength training as an important contribution to healthy aging.