bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clival Osteomyelitis Presenting as a Skull Base Mass
Authors: Michalowicz Matthew , Ramanathan Murugappan 
Published: June 2017

AbstractCentral skull base osteomyelitis is a rare, but potentially life-threatening disease entity often lacking otologic symptoms or external auditory canal pathology. We present a case of a man in his 70s who had developed cranial nerve deficits with radiographic evidence that was consistent with a tumor due to this uncommon entity. The radiologic findings and our experience are discussed to increase awareness in the otolaryngology community.
Patienten zeigen sich zufrieden mit der Arzt-Patienten-Kommunikation – eine Pilotstudie mit dem „Individual Clinician Feedback“- Fragebogen
Authors: Prengel Peggy , Kotte Nina , Antoine Sunya-Lee , Eikermann Michaela , Neugebauer Edmund , Stahl Katja , Pieper Dawid 
Published: June 2017

Zusammenfassung
Ziel der Studie Die Patientenzentrierung als ein wesentliches Qualitätsmerkmal der Patientenversorgung gewinnt immer mehr an Bedeutung. Das Ziel des Pilotprojektes ist es, Einblicke in die Arzt-Patienten-Kommunikation aus Patientensicht zu gewinnen. Im Vordergrund steht die Erprobung des deutschen Fragebogens in einer Klinik der Maximalversorgung.
Methodik Der deutsche „Individual Clinician Feedback“- Fragebogen (ICF) wurde in einer Pilotstudie in den Spezialsprechstunden einer Klinik an einer freiwilligen Kohorte chirurgisch tätiger Ärzte getestet. Im Erhebungszeitraum von Juni – August 2015 wurde der Fragebogen an die Patienten ausgegeben. Dem Arzt werden seine Bewertungsergebnisse (Feedback) in komprimierter Form als Score zur Verfügung gestellt. Die Bewertung erfolgt auf einer Skala von 1 bis 10, wobei 10 „sehr gut“ ist.
Ergebnisse Es wurden 12 Ärzte aus 5 Fachabteilungen rekrutiert. Es konnte eine hohe Rücklaufquote von 46% (n=219) erzielt werden. Die Kommunikation bewerten die Patienten als sehr gut (im Mittel über alle Items und Ärzte 8,5–9,5 Punkte). 89% der Patienten hatten das Gefühl, dass sich der Arzt genügend Zeit für sie genommen hat, dabei waren 50% der Patienten 11–20 min beim Arzt. Für 12% der Patienten bestanden nach der Behandlung noch offene Fragen, die sie nicht gestellt haben. Zu 19 bzw. 21% gaben die Patienten an, dass der Arzt nicht angeboten hat, Fragen zu stellen oder dass sie es einfach am Ende der Behandlung vergessen haben.
Schlussfolgerung Die Ergebnisse der Pilotstudie gehen mit einer guten Rücklaufquote einher und die Patienten zeigten sich größtenteils sehr zufrieden mit der Arzt-Patienten-Kommunikation. Ein Selektionsbias unter den teilnehmenden Ärzten ist jedoch wahrscheinlich.
Eine Aufgabe mit Schlüsselfunktion
Authors: Stricker Cornelia , Schlüer Anna-Barbara , Händler-Schuster Daniela 
Published: June 2017

Zusammenfassung
Erfahrungsbericht Im Rahmen ihres Studiums Master of Science in Nursing an
der Zürcher Hochschule für Angewandte Wissenschaften in Winterthur absolvierte
Cornelia Stricker ein Workshadowing im Pflegedienst des
Universitätskinderspitals Zürich. Innerhalb von zwei Wochen erhielt sie einen
direkten Einblick in die Pflegepraxis der Pflegeexpertinnen APN Kardiologie, APN
Onkologie und APN Kontinenz und über ihre Verankerung in der klinischen Praxis.
Hier beschreibt sie die vielfältigen Aufgaben pädiatrischer Pflegeexperten APN
in der klinischen Praxis und zeigt Möglichkeiten des Umgangs auf.
Morbiditätskompression bei Schlaganfall? Langzeitanalysen zur Veränderung des Auftretens von Schlaganfall
Authors: Bachus Lena , Eberhard Sveja , Weißenborn Karin , Muschik Denise , Epping Jelena , Geyer Siegfried 
Published: June 2017

Zusammenfassung
Ziel der Studie Nach Fries liegt Morbiditätskompression dann vor, wenn das Alter des Eintretens von Krankheit und chronischer Behinderung und Tod über die Zeit ansteigt oder wenn Erkrankungsraten über die Zeit stärker oder im gleichen Maße sinken wie die standardisierten Sterberaten. In beiden Fällen wird gesunde Lebenszeit gewonnen. Die Befunde der bisher durchgeführten Studien sind uneinheitlich, und es gibt nur wenige zu spezifischen Erkrankungen. Am Beispiel des Schlaganfalls wird untersucht, ob über den untersuchten Neunjahreszeitraum Morbiditätskompression stattgefunden hat. Dies bezieht sich auf Veränderungen der Raten von Schlaganfall und Tod. Zusätzlich wird untersucht, ob sich das Alter bei Manifestation von Schlaganfall und das Sterbealter wie von Fries angenommen bei Frauen und Männern nach oben verschieben.
Methodik Die Analysen basieren auf den pseudonymisierten Daten einer gesetzlichen Krankenversicherung der Jahre 2006–2014. Die Analysen wurden für alle Schlaganfälle sowie differenziert nach Hirninfarkten und Blutungen (ICD 10: I60-I62) durchgeführt. Für jedes Jahr standen die Daten von ca. 2 Mio. Versicherten zur Verfügung. Die Berechnungen wurden mit Survivalanalysen sowie mit multivariater Regression durchgeführt.
Ergebnisse Die Raten reduzierten sich bei beiden Geschlechtern, jedoch nur für blutungsbedingte Schlaganfälle. Die Veränderungen des Eintrittsalters waren schwer interpretierbar. Das Sterbealter sowie die standardisierten Sterberaten veränderten sich nur bei Männern.
Schlussfolgerung Belege für die Kompressionsthese wurden nur für Änderungen in den Raten blutungsbedingter Schlaganfälle gefunden. Diese Befunde beziehen sich auf eine einzige Erkrankung, die relativ spät im Lebensverlauf eintritt. Eine abschließende Beurteilung über das Vorliegen von Morbiditätskompression ist erst nach der Untersuchung einer breiten Spanne von Erkrankungen möglich.
Secular rise in economically valuable personality traits
Authors: Jokela Markus , Pekkarinen Tuomas , Sarvimäki Matti , Terviö Marko , Uusitalo Roope 
Published: June 2017

Significance
The secular rise in intelligence across birth cohorts is one of the most widely documented facts in psychology. This finding is important because intelligence is a key predictor of many outcomes such as education, occupation, and income. Although noncognitive skills may be equally important, there is little evidence on the long-term trends in noncognitive skills due to lack of data on consistently measured noncognitive skills of representative populations of successive cohorts. Using test score data based on an unchanged test taken by the population of Finnish military conscripts, we find steady positive trends in personality traits that are associated with high income. These trends are similar in magnitude and economic importance to the simultaneous rise in intelligence.
Future of fundamental discovery in US biomedical research
Authors: Levitt Michael , Levitt Jonathan M. 
Published: June 2017

Significance
Innovative fundamental basic science research is traditionally done by young people. This makes the steady fall in the number of younger US basic scientists a serious concern. Our analysis suggests that this happened mainly due to a bias against younger applicants, with more money going to older principal investigators (PIs). We also find a large number of postdoctoral scholars and research associates, a rapid rise in number of PIs over 71, and a steady shift of NIH funds away from R01 grants. NIH is attempting to deal with some of these issues.
Stability of ferrous-iron-rich bridgmanite under reducing midmantle conditions
Authors: Shim Sang-Heon , Grocholski Brent , Ye Yu , Alp E. Ercan , Xu Shenzhen , Morgan Dane , Meng Yue , Prakapenka Vitali B. 
Published: June 2017

Significance
This paper reports an unexpected change in the oxidation state of Fe in bridgmanite, the most dominant mineral in the lower mantle. The oxidation state change resolves the discrepancy between laboratory and seismic studies on the chemical composition of the lower mantle, showing that the lower mantle has major element chemistry similar to the upper mantle. The oxidation state change will also lead to a lower Fe content in bridgmanite in the midmantle, whereas the total Fe content remains the same. Such a change can lead to an increase in viscosity at 1,100- to 1,700-km depths, providing a viable mineralogical explanation on possible viscosity elevation suggested by geophysical studies at the same depth range.
An Exportin-1–dependent microRNA biogenesis pathway during human cell quiescence
Authors: Martinez Ivan , Hayes Karen E. , Barr Jamie A. , Harold Abby D. , Xie Mingyi , Bukhari Syed I. A. , Vasudevan Shobha , Steitz Joan A. , DiMaio Daniel 
Published: June 2017

Significance
Quiescence is a growth-arrested cellular state; genes involved in this process are finely regulated by several factors, including miRNAs. During miRNA biogenesis, Exportin-5 transports miRNA precursors from the nucleus to the cytoplasm. In this study, we demonstrated the existence of an alternative miRNA biogenesis pathway in quiescent primary human cells. This pathway involves the repression of Exportin-5 expression by autophagy and miRNAs and the 2,2,7-trimethylguanosine-cap modification of specific primary miRNAs (pri-miRNAs), which signal their export to the cytoplasm by Exportin-1. We further showed that these pri-miRNAs are processed rapidly in the cytoplasm by a small isoform of Drosha. Collectively, these results reveal an alternative mechanism of miRNA biogenesis that will expand our understanding of miRNA regulation in normal or disease-related cells.
Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants
Authors: Chekan Jonathan R. , Estrada Paola , Covello Patrick S. , Nair Satish K. 
Published: June 2017

Significance
The class of bioactive cyclic plant natural products called orbitides was first identified nearly half a century ago. Here we describe how a single enzyme can catalyze the cyclization of a range of ribosomally synthesized linear peptides into the corresponding cyclic products of varying ring sizes. These studies may provide a means for producing large libraries of cyclic peptides without any sequence bias.
Temperature variability is integrated by a spatially embedded decision-making center to break dormancy in
Arabidopsis
seeds
Authors: Topham Alexander T. , Taylor Rachel E. , Yan Dawei , Nambara Eiji , Johnston Iain G. , Bassel George W. 
Published: June 2017

Significance
Both plants and animals make decisions in response to the environment to maximize their fitness. Plants use dormancy in seeds to move through time and space, and timing of the transition to germination is influenced by external cues, including temperature. Here, we report the presence of a decision-making center within the root tip of dormant seeds and demonstrate that it shares a similar configuration as some systems within the human brain. Unlike in humans, where this spatial structure is used to filter out noisy inputs from the environment, seeds use this arrangement to harness fluctuating temperatures and stimulate the termination of dormancy. Variable inputs therefore act as an instructive signal for seeds, enhancing the accuracy with which plants are established in ecosystems.
Dapagliflozin suppresses glucagon signaling in rodent models of diabetes
Authors: Wang May-yun , Yu Xinxin , Lee Young , McCorkle Sara Kay , Chen Shiuhwei , Li Jianping , Wang Zhao V. , Davidson Jaime A. , Scherer Philipp E. , Holland William L. , Unger Roger H. , Roth Michael G. 
Published: June 2017

Significance
Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower blood glucose in humans with diabetes. These drugs inhibit the reabsorption of glucose in the kidney, resulting in its urine excretion. It was reported that SGLT2 inhibitors increase the secretion of glucagon and increase endogenous glucose production by the liver. These effects would elevate blood glucose, counteracting the effect of urinary glucose loss. Here we show in a rodent model of type 1 diabetes that the SGLT2 inhibitor dapagliflozin inhibited the secretion of glucagon from the pancreas. In two rodent models of severe type 2 diabetes, livers from animals treated with dapagliflozin showed decreased glucagon signaling and had reduced expression of the glucagon receptor. Our results suggest dapagliflozin lowers blood glucose concentrations in diabetic animals in part through inhibiting hepatic glucagon signaling.
Achievements
Authors: Strong Samuel 
Published: June 2017

Abstract
Achievements perform an essential entertainment function in video games. They instruct and reward gamers, and they serve as status symbols or bragging rights within gaming communities. These texts can be challenging for localisers, since they have multiple functions, align with or subvert game mechanics and narrative, and can contain a range of intertextual references, understood as references to other texts, genres, or popular culture (Mangiron and O’Hagan, 2006). Their localisation, therefore, warrants special handling. In this article, I make the case for achievement texts being a unique text type based on Bernal-Merino’s (2014) classification. Further, I propose a macro-level analysis approach that enables localisers to re-render these texts’ essential component parts.
Cross-linguistic influence in scope ambiguity
Authors: Meroni Luisa , Smeets Liz , Unsworth Sharon 
Published: June 2017

Abstract
Cross-linguistic influence of interface-conditioned properties in bilingual language acquisition has been reported in a large number of studies and various linguistic domains. While many of these studies have found that cross-linguistic influence can occur in the form of delay, few have shown evidence for acceleration (a.o., Kupisch, 2007; Meisel, 2007; Schwartz, Nir, Leikin, Levie, & Ravid, 2014). In this paper we investigate the interpretation of indefinites in sentences containing negation by simultaneous bilingual (2L1) English-Dutch and Italian-Dutch children. Our results provide evidence for cross-linguistic influence from Italian to Dutch in the form of acceleration, only. We conclude that in cases of partial overlap between a bilingual child’s two languages, the direction of cross-linguistic influence can also depend on language-internal properties.
Subtle aspectual differences in the L2 acquisition of German
Authors: Miller David , DeLuca Vincent , Berndt Denny , Iverson Michael , Rothman Jason 
Published: June 2017

Abstract
We examine the acquisition of progressivity in the German simple present tense (GPT) and related constructions by English natives of L2 German, under the guise of the Feature Reassembly Hypothesis. German lacks an explicit gerundial form; the AM + infinitive (am) and BEIM + infinitive (beim) constructions express progressivity, along with the GPT. Although semantically the am and beim constructions map to the English copula + gerund, their unique syntax creates grammaticality differences. We employ three experiments testing (1) the acquisition of the aspectual properties of the GPT, and knowledge of the (2) semantic distribution of, and (3) syntax of am and beim. Data from a control group (n = 25) and adult L2s (n = 20) suggest adult L2 feature reassembly is possible, albeit complicated.
Cross-linguistic influence meets language impairment
Authors: Tsimpli Ianthi Maria , Peristeri Eleni , Andreou Maria 
Published: June 2017

Abstract
Our study investigates the use of articles and object clitics in the L2-Greek of child speakers of Russian with and without Specific Language Impairment. Effects of language impairment were examined in the narratives of children whose languages differ in the expression of definiteness: Russian lacks articles and allows null objects with specific reference, while Greek requires object clitics in the same context and has definite and indefinite articles. Language impairment led to more article and clitic omission in obligatory contexts, as well as more substitution errors in clitics. The bilingual children with SLI lagged behind TD bilingual Russian-Greek peers in both grammatical knowledge of functional categories related to the D system in Greek and access to discourse information influencing definiteness.
Bioenergetics Models to Estimate Numbers of Larval Lampreys Consumed by Smallmouth Bass in Elk Creek, Oregon
Authors: Schultz L. D. , Heck Michael P. , Kowalski Brandon M. , Eagles-Smith Collin A. , Coates K. , Dunham Jason B. 
Published: June 2017

Abstract
Nonnative fishes have been increasingly implicated in the decline of native fishes in the Pacific Northwest. Smallmouth Bass Micropterus dolomieu were introduced into the Umpqua River in southwest Oregon in the early 1960s. The spread of Smallmouth Bass throughout the basin coincided with a decline in counts of upstream-migrating Pacific Lampreys Entosphenus tridentatus. This suggested the potential for ecological interactions between Smallmouth Bass and Pacific Lampreys, as well as freshwater-resident Western Brook Lampreys Lampetra richardsoni. To evaluate the potential effects of Smallmouth Bass on lampreys, we sampled diets of Smallmouth Bass and used bioenergetics models to estimate consumption of larval lampreys in a segment of Elk Creek, a tributary to the lower Umpqua River. We captured 303 unique Smallmouth Bass (mean: 197 mm and 136 g) via angling in July and September. We combined information on Smallmouth Bass diet and energy density with other variables (temperature, body size, growth, prey energy density) in a bioenergetics model to estimate consumption of larval lampreys. Larval lampreys were found in 6.2% of diet samples, and model estimates indicated that the Smallmouth Bass we captured consumed 925 larval lampreys in this 2-month study period. When extrapolated to a population estimate of Smallmouth Bass in this segment, we estimated 1,911 larval lampreys were consumed between July and September. Although the precision of these estimates was low, this magnitude of consumption suggests that Smallmouth Bass may negatively affect larval lamprey populations.
Received September 20, 2016; accepted March 31, 2017Published online June 6, 2017
Opioid vs Nonopioid Prescribers: Variations in Care for a Standardized Acute Back Pain Case
Authors: Hanley Kathleen , Zabar Sondra , Altshuler Lisa , Lee Hillary , Ross Jasmine , Rivera Nicomedes , Marvilli Christian , Gillespie Colleen 
Published: June 2017

Background Opioid analgesics are effective and appropriate therapy for many types of acute pain. Epidemiologic evidence supports a direct relationship between increased opioid prescribing and increases in opioid use disorders and overdoses. Objective: To tailor our residency curriculum, we designed and fielded an unannounced standardized patient (USP) case involving a patient with acute back pain who is requesting Vicodin (5/325 mg). We describe residents’ case management and examine whether their management decisions, including opioid prescribing, were related to their core clinical skills. Methods Results are based on 50 (USP) visits with residents in 2 urban primary care clinics. Highly trained USPs portrayed a patient with acute lower back pain who was taking leftover Vicodin with effective pain relief but was running out. We describe how residents managed this case, using both USP report and chart review data, and compare summary clinical skills scores between those who prescribed Vicodin and those who did not. Results Of the 50 residents, 18 prescribed Vicodin (10–60 pills). Among those who did not prescribe (32/50), most (50%) prescribed ibuprofen. Eighty-three percent of the prescribers and 72% of nonprescribers ordered physical therapy (nonsignificant). Of the 18 prescribers, 13 documented checking the prescription monitoring database. Prescribers had significantly better communication scores than nonprescribers (relationship development: 80% vs. 58% well done, P = .029; patient education: 59% vs. 31% well done, P = .018). Assessment summary scores were also higher (60% vs. 46%) but not significantly ( P = .060). Patient satisfaction and activation scores were higher in the prescribers than nonprescribers (71% vs. 39%, P = .004 and 48% vs. 26%, P = .034, respectively). Conclusions Most Vicodin prescribers did not follow prescribing guidelines, and they demonstrated better communication and assessment skills than the nonprescribers. Results suggest the need to guide residents in using a systematic approach to prescribing opioids safely and to develop an acceptable alternative pain management plan when they decide against prescribing.
Storied Objects, Scientific Objects, and Renaissance Experiment: The Case of Malleable Glass
Authors: Keller Vera 
Published: June 2017

AbstractThe career of storied objects can help highlight the agency of absence and historicize the notion of scientific objects more generally. Until the sixteenth century, lost, ancient flexible glass was studied separately from malleable glass. The latter appeared as a claimed chymical product and craft recipe. The bridging of social and epistemic registers merged these accounts. Malleable glass became a prestigious scientific object. Appearing in numerous utopias, it stimulated a participatory public of scientific amateurs. Such storied objects served as vectors for spreading experimental culture, yet declined as new professions emerged. The charisma that made malleable glass a seventeenth-century scientific object led to its rejection by newly professionalized eighteenth-century chemists and its replacement by a less evocative scientific object, “malleability.”
runBNG: a software package for BioNano genomic analysis on the command line
Authors: Yuan Yuxuan , Bayer Philipp E , Lee Huey-Tyng , Edwards David 
Published: June 2017

Abstract

Summary
We developed runBNG, an open-source software package which wraps BioNano genomic analysis tools into a single script that can be run on the command line. runBNG can complete analyses, including quality control of single molecule maps, optical map de novo assembly, comparisons between different optical maps, super-scaffolding and structural variation detection. Compared to existing software BioNano IrysView and the KSU scripts, the major advantages of runBNG are that the whole pipeline runs on one single platform and it has a high customizability.

Availability and implementation
runBNG is written in bash, with the requirement of BioNano IrysSolve packages, GCC, Perl and Python software. It is freely available at https://github.com/appliedbioinformatics/runBNG.

Supplementary information
Supplementary data are available at Bioinformatics online.
MoDMaps3D: an interactive webtool for the quantification and 3D visualization of interrelationships in a dataset of DNA sequences
Authors: Karamichalis Rallis , Kari Lila 
Published: June 2017

Abstract

Summary
MoDMaps3D (Molecular Distance Maps 3D) is an alignment-free, fast, computationally lightweight webtool for computing and visualizing the interrelationships within any dataset of DNA sequences, based on pairwise comparisons between their oligomer compositions. MoDMaps3D is a general-purpose interactive webtool that is free of any requirements on sequence composition, position of the sequences in their respective genomes, presence or absence of similarity or homology, sequence length, or even sequence origin (biological or computer-generated).

Availability and implementation
MoDMaps3D is open source, cross-platform compatible, and is available under the MIT license at http://moleculardistancemaps.github.io/MoDMaps3D/. The source code is available at https://github.com/moleculardistancemaps/MoDMaps3D/.

Supplementary information
Supplementary data are available at Bioinformatics online.