bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemosensitizing Activity of Histone Deacetylases Inhibitory Cyclic Hydroxamic Acids for Combination Chemotherapy of Lymphatic Leukemia
Authors: Mishchenko Denis V. , Neganova Margarita E. , Klimanova Elena N. , Sashenkova Tatyana E. , Klochkov Sergey G. , Shevtsova Elena F. , Vystorop Igor V. , Tarasov Vadim V. , Chubarev Vladimir N. , Samsonova Anna N. , Ashraf Ghulam Md , Barreto George , Yarla Nagendra Sastry , Aliev Gjumrakch 
Published: December 2017

Background:
Anti-tumor effect of hydroxamic acid derivatives is largely connected with
its properties as efficient inhibitors of histone deacetylases, and other metalloenzymes involved in
carcinogenesis.

Objective:
The work was aimed to (i) determine the anti-tumor and chemosensitizing activity of the
novel racemic spirocyclic hydroxamic acids using experimental drug sensitive leukemia P388 of mice,
and (ii) determine the structure-activity relationships as metal chelating and HDAC inhibitory agents.

Method:
Outbreed male rat of 200-220 g weights were used in biochemical experiments. In vivo
experiments were performed using the BDF1 hybrid male mice of 22-24 g weight. Lipid peroxidation,
Fe (II) -chelating activity, HDAC fluorescent activity, anti-tumor and anti-metastatic activity,
acute toxicity techniques were used in this study.

Results:
Chemosensitizing properties of water soluble cyclic hydroxamic acids (CHA) are evaluated
using in vitro activities and in vivo methods and found significant results. These compounds possess
iron (II) chelating properties, and slightly inhibit lipid peroxidation. CHA prepared from triacetonamine
(1a-e) are more effective Fe (II) ions cheaters, as compared to CHA prepared from 1-
methylpiperidone (2a-e). The histone deacetylase (HDAC) inhibitory activity, lipophilicity and acute
toxicity were influenced by the length amino acids (size) (Glycine < Alanine < Valine < Leucine
< Phenylalanine). All compounds bearing spiro-N-methylpiperidine ring (2a-e) are non-toxic up to
1250 mg/kg dose, while compounds bearing spiro-tetramethylpiperidine ring (1a-e) exhibit moderate
toxicity which increases with increasing lipophility, but not excite at 400 mg/kg.

Conclusion:
It was shown that the use of combination of non-toxic doses of cisplatin (cPt) or cyclophosphamide
with CHA in most cases result in the appearance of a considerable anti-tumor effect of
cytostatics. The highest chemosensitizing activity with respect to leukemia Р388 is demonstrated by
the CHA derivatives of Valine 1c or 2c.
The Effect of Flubendazole on Adhesion and Migration in SW480 and SW620 Colon Cancer Cells
Authors: Hanušová Veronika , Skálová Lenka , Králová Věra , Matoušková Petra 
Published: December 2017

Background:
Colon cancer is the most common type of gastrointestinal cancer. Despite advances
during the last two decades, the efficacy of colorectal cancer treatment is still insufficient and new anticancer
agents are necessary.

Methods:
In our study, colon cancer cells derived from a primary tumor (SW480) and lymph node metastasis
(SW620) from the same patient were used and compared. The effect of flubendazole (FLU) on cell adhesion and
migration was monitored using the x-CELLigence Real-Time Cell Analysis system. Expressions of molecules involved
in adhesion and migration were analyzed using RT-PCR and western blot. Furthermore, RNA silencing of
nuclear factor-κB in SW620 cells was used to determine the involvement of the NF-κB p65 regulation pathway
in FLU action.

Results:
FLU significantly suppressed the adhesion of SW480 cells and reduced the expression of adhesion
markers (ICAM-1, αE-catenin; β-catenin; integrin α5 and β1). Moreover, a significant anti-migratory potential
of FLU was manifested in the SW620 cells. In addition, FLU suppressed the phosphorylation of NF-κB p65 and
potentiated the suppression of several metastatic markers (ICAM-1, EpCAM, integrin α5, β1, α-tubulin) caused
by NF-κB p65 silencing.

Conclusion:
FLU has a significant anti-migratory effect in intestinal cancer cell SW480 and its lymph node
metastatic cells SW620. FLU decreases the expression of some proteins involved in metastatic processes and
inhibits activation of NF-κB p65.
Karakter Seleksi pada Generasi Awal untuk Adaptasi Padi terhadap Cekaman Suhu Tinggi
Authors: Manalu Victor Manotar Pademan , Wirnas Desta , Sudarsono Dan 
Published: December 2017

<div class="WordSection1"><p align="center"><strong>ABSTRACT</strong></p><p align="center"><strong> </strong></p><p><em> Developing new rice varieties adaptive to heat stress is important to maintain high rice production in anticipating global warming effects. This research was aimed to find selection characters and to select the best segregant in early generation based on agronomic characters for adaptation of rice to heat stress. The experiment was carried out in September 2014 to Januari 2015. About 210 F2 segregants generated trough hybridization between IPB 4S (sensitive parent) and Situ Patenggang (tolerant parent), 20 individuals of IPB 4S, and 20 individuals of Situ Patenggang, were used as genetic control. All genetic materials were exposed to high temperature stress by growing in a green house of Bogor Agricultural University. The average temperature in the research period was 24 °C and 42.09 °C, respectively for minimum and maximum temperature. The results showed that charachters of productive and total tiller number, total grain number, and seed weight had high heritability, high coeffiecient of genetics variability-with an additive gene action. That charachters could be proposed as selection criteria in early generation for rice breeding of adaptation to high temperature stress. The characters could be applied in either single trait or multiple traits selection. Based on multiple traits selection we found 50 the best F2 segregation.<br /><br />Keywords: differential selection, early generation, heat tolerant, heritability, gene action, variability genetics coeffiecient <br /><br /></em><strong><em></em></strong><br clear="all" /><strong><em> </em></strong></p></div>
La noción de "alma bella" en el pensamiento de Hölderlin de Hegel
Authors: Alfaro Carlos 
Published: December 2017

Varios comentaristas sostienen que el pensamiento de Friedrich Hölderlin es un ejemplo de la concepción hegeliana de «alma bella». En el presente artículo, se demostrará que la figura del Espíritu antes mencionada tiene fundamentos ontológicos que difieren del contenido de la noción de «alma bella» concebida por Hölderlin.
The e-Learning Needs Analysis in Graduate Programs of Universitas Negeri Makassar
Authors: Hasyim Nurhikmah , Haling Abdul 
Published: December 2017

This research aims to develop learning materials and tutorial videos e-learning for students of PPs UNM. Accurately, this research will produce learning materials, video tutorials, and scholarly articles. Product development refers to the ADDIE model (Analysis-Design-Develop-Implement-Evaluate) developed by Reiser and Mollenda in 1990. The research subject is graduate PPs UNM and the data gathering methods are documentation, interview, questionnaire, and tests, then analyzed by the descriptive qualitative method. In the first stage of research conducted analysis, i.e., identifying characteristics or profiles of prospective participants learn, identify gaps, and the identification of needs. The result shows, 1) characteristic of participants, i.e., in the range 25-35 years adult category, the respondent's gender dominated by women and respondents are dominated by kindergarten teacher/PAUD until lecturer, and they have a very high motivation to learn the program; 2) Some gap identify based on question form given to the respondents, i.e., they strongly agree with the application of e-learning-based lesson at school and University, but abilities and skills related to the program is still very limited; and 3) needed learning materials in the form of video tutorials that can help them to learn independentlyÂ and master the lesson of e-learning based program.
Potential of Red Spinach Leaves Ethanolic Extract (Amaranthus tricolor L.) as a Complementary Therapy For Hiperlipidemia: Study in Vivo of Histopathologic and Activity of Alanin Aminotransferase (ALT)
Authors: Pradana Dimas Adhi , Anggriani Irna Destya , Setyaningrum Tri Ratna 
Published: December 2017

This study was conducted to determine the potential of ethanolic extract of red spinach leaves (Amaranthus tricolor L.) with control quality as a complementary treatment of hyperlipidemic based on histopathology and activity of alanin aminotrasferase (ALT). A total of 24 male Wistar rats were randomized in 6 groups: normal group; positive control group were given the drug simvastatin; negative control group; 1st treatment group was given extract at dose of 400mg/kgBW rat, 2nd group was given extract at dose of 400mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat; 3rd treatment groups were given extract at dose of 800mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat. Induction hyperlipidemic using high fat diet and poloxamer. The data obtained were tested normality with the Shapiro-Wilk test. Statistical analysis using Oneway ANOVA and Post-Hoc Tukey HSD to determine the significance of differences between groups for ALT parameter. Result show the use of ethanolic extract of red spinach leaves can reduce fatty liver condition based on decreased level of ALT and liver histopathologic. It is concluded that the ethanolic extract of red spinach leaves dose 400mg/kgBW rat combine with simvastatin can reduce activity of ALT until 31.57 U1-1.
MINYAK KENANGA (Canangium odoratum Baill) SEBAGAI REPELLENT LALAT RUMAH (Musca domestica)
Authors: Sari Wijayanti Ratna , Muryoto Muryoto , Kadarusno Abdul Hadi 
Published: December 2017

Lalat merupakan vektor beberapa penyakit seperti disentri, kholera, typhoid, diare, dan kecaci-ngan. Berbagai teknik pengendalian lalat dapat dilakukan, salah satunya dengan cara kimia menggunakan repellent. Minyak kenanga (Canangium odoratum Baill) mempunyai kemampuan sebagai repellent lalat karena mengandung linalool, eugenol dan geraniol yang merupakan senyawa fenol penolak serangga. Tujuan penelitian ini untuk mengetahui pengaruh pengguna-an variasi konsentrasi minyak kenanga terhadap lalat rumah (Musca domestica) dengan me-ngukur daya dan durasi dari repellent yang diperoleh. Penelitian bersifat experiment dengan memakai post-test only with control group design. Obyek penelitian, yaitu lalat rumah yang ber-jumlah 625 ekor, digunakan untuk lima kelompok penelitian yang terdiri dari tiga kelompok per-lakuan dan dua kelompok kontrol dengan pengulangan sebanyak lima kali. Hasil uji dengan one way anova pada α 0,05, memperlihatkan bahwa daya repellent yang dimiliki oleh konsen-trasi minyak kenanga 20 %, 30 %, dan 40 %, serta kontrol positif (kamfer) dan kontrol negatif (minyak jarak) berbeda secara bermakna, sehingga dapat disimpulkan bahwa konsentrasi mi-nyak kenanga berpengaruh terhadap daya repellent. Namun, tehadap durasi, pengaruhnya ti-daklah signifikan. Penelitian menyimpulkan bahwa konsentrasi 40 % (40 ml minyak kenanga dalam 60 ml minyak jarak) adalah yang paling efektif untuk mengusir lalat rumah, dengan daya repellent sebesar 34,4 % dan durasi 8,4 jam.
HUBUNGAN TEMPAT PENAMPUNGAN AIR BUATAN DENGAN KEBERADAAN JENTIK Aedes aegypti DI DUSUN KEBONAGUNG DESA TRIDADI KECAMATAN SLEMAN KABUPATEN SLEMAN
Authors: Sekarwati Novita 
Published: December 2017

Sangat rendahnya ABJ di Dusun Kebonagung (5,26 %) dibandingkan angka nasional (95 %) di-pengaruhi oleh beberapa faktor yaitu perilaku penduduk menampung air untuk keperluan sehari-hari tidak hanya pada satu tempat dan jarang membersihkan bak penampungan air. Tujuan penelitian ini adalah untuk mengetahui hubungan tempat penampungan air buatan dan keber-adaan jentik nyamuk Aedes aegypti di Dusun Kebonagun yang terletak di Desa Tridadi Keca-matan Sleman Kabupaten Sleman. Metoda penelitian yang digunakan adalah observasional analitik dengan desain cross sectional. 106 buah rumah sampel diperoleh dengan menggunakan teknik simple random sampling. Data dikumpulkan dengan menggunakan check-list serta be-berapa alat bantu untuk pemeriksaan jentik. Hasil penelitian menemukan bahwa tempat penam-pungan air buatan yang positif jentik nyamuk Aedes aegypti sebanyak 12 buah dengan nilai HI 11,32 %. Berdasarkan hasil uji dengan Fisher’s Exact pada derajat kepercayaan 95 %, diketahui bahwa antara tempat penampungan air buatan dan keberadaan jentik Aedes aegypti, ada hu-bungan yang bermakna (nilai p < 0,001). Dari hasil uji regresi logistik diperoleh nilai Exp(B) se-besar 0,128 yang berarti bahwa tiap satu tempat penampungan air buatan akan meningkatkan risiko keberadaan jentik nyamuk Aedes aegypti sebesar 0,128 kali.
Analisis Faktor Risiko Kecelakaan Kerja pada Tenaga Kerja Produksi PT Indotama Omicron Kahar di Purworejo, Jawa Tengah
Authors: Pravitra Disca , Bagyono Tuntas , Hendrarini Lilik 
Published: December 2017

Kecelakaan kerja adalah suatu kejadian yang tidak dikehendaki oleh tenaga kerja. Pencegahan terhadap hal tersebut perlu dilakukan dengan cara menganalisis faktor risiko yang meliputi: penggunaan APD, perilaku kerja serta faktor peralatan yang terdiri dari tata letak alat dan peng-aman mesin. Penelitian ini bertujuan untuk mengetahui faktor risiko penyebab terjadinya kece-lakaan akibat kerja pada tenaga kerja produksi bagian pengupasan kulit di PT Indotama Omi-cron Kahar di Purworejo, Jawa Tengah, dengan melakukan cross sectional survey. Sampel pe-nelitian adalah seluruh 140 tenaga kerja di bagian pengupasan kulit. Hasil penelitian dianalisis secara deskriptif dan analitik dengan uji korelasi Pearson dengan tingkat signifikansi 95 %. Hasil dan kesimpulan dari penelitian ini menunjukkan bahwa: ada hubungan antara penggunaan APD dengan kejadian kecelakaan kerja (p-value < 0,001); ada hubungan antara perilaku kerja de-ngan kejadian kecelakaan kerja (p-value 0,003); ada hubungan antara tata letak alat dengan ke-jadian kecelakaan kerja (p-value < 0,001); dan peralatan kerja yang tidak terdapat pengaman mesin memiliki prosentase kecelakaan kerja sebanyak 67,3 % atau dialami oleh 70 responden. Pihak industri disarankan untuk memberi penyuluhan pada tenaga kerja mengenai pentingnya penggunaan APD pada saat bekerja, melakukan kajian mengenai tata letak mesin dan peralatan produksi, serta melengkapi peralatan yang digunakan dengan pengaman mesin.
O sistema cicloviário como alternativa para a mobilidade urbana: uma análise em piracicaba – são paulo. - Cycling system as an alternative for urban mobility: an analysis in piracicaba- são paulo.
Authors: Diego Gobbo Alves José , Leonardo Rodrigues da Cunha Eric 
Published: December 2017

RESUMOAs cidades brasileiras enfrentam sérios problemas de mobilidade urbana causados, principalmente, pelo padrão de desenvolvimento urbano (disperso, segregado e dependente do modal rodoviário). O aumento dos congestionamentos e acidentes, a precariedade do transporte coletivo público, o aumento das distâncias percorridas no cotidiano e a falta de infraestruturas necessárias tem se tornando, cada vez mais, problemas estruturais nas cidades. Este artigo propõe um diagnóstico da mobilidade urbana em Piracicaba, interior do estado de São Paulo, através do sistema cicloviário como alternativa para o panorama atual de mobilidade na cidade. Como metodologia, realizou-se levantamento bibliográfico, de dados e documental; trabalhos em campo e mapeamento temático. Os resultados desta pesquisa apontam para sérios problemas da mobilidade urbana apresentados na cidade, tais como o aumento na frota de automóveis (67%) e motocicletas (150%) entre os anos de 2002 e 2015 além de um sistema cicloviário deficitário, com trechos que não interligam as principais áreas das cidades, possuindo um caráter de lazer ao invés de funcional para as atividades do cotidiano da população.Palavras-chaves: Mobilidade Urbana; Sistema cicloviário; Piracicaba – São Paulo. ABSTRACTBrazilian cities have been facing serious urban mobility problems caused mainly by the pattern of urban development (dispersed, segregated and road modal dependent). The increases in traffic jams and accidents, the precarious public transport, the increase in daily life distances and the lack of necessary infrastructure are increasingly becoming structural problems in cities. This article proposes a diagnosis of urban mobility in the Piracicaba, in São Paulo state interior, through the bicycle system as an alternative to the current panorama of mobility in the city. As methodology, a bibliographical and data survey was carried out, also field work and thematic mapping. The results show serious urban mobility problems in the city, such as the increase in the car fleet (67%) and motorcycles (150%) from 2002 to 2015 and a deficient bicycle system, with non-interconnected paths to the city’s main areas and having a leisure character rather than functional for the population daily activities.Keywords: Urban Mobility; Bicycle path system; Piracicaba - São Paulo.
An evaluation of the clinical skills and experience within an orthopaedic Integrated Clinical Assessment and Treatment Service
Authors: Feist-Wilson Simon , Heron Neil 
Published: December 2017

BackgroundGeneral practice in the UK is ‘in crisis’. With 20% of GP workload relating to musculoskeletal (MSK) problems, an orthopaedic Integrated Clinical Assessment and Treatment Service (ICATS) could help support assessment of these patients in primary care, alleviating pressure on GPs. However, practitioners in ICATS must be trained appropriately to ensure its effectiveness.AimThis evaluation aimed to identify the training levels of doctors in one Northern Ireland orthopaedic ICATS system, what their future training needs are, and suggestions for how this service could be improved to better support general practice.Design & settingA questionnaire study in an orthopaedic ICATS, Northern Ireland.MethodAll seven doctors working within the Southern Trust orthopaedic ICATS were asked to complete a questionnaire detailing their training and experience in MSK medicine. Their views on how the service could be improved were elicited.ResultsSix of seven questionnaires were returned. All responders were Members of the Royal College of General Practitioners (MRCGP), while five of six held a Diploma in Sports and Exercise Medicine (Dip SEM). Half of responders suggested that MSK ultrasound could be beneficial within ICATS. However, it was viewed that extensive training would be required before paediatric MSK patients could be included.ConclusionHigh levels of training and experience were reported by responders, suggesting ICATS provides a high-level MSK service. Furthermore, it was noted that inclusion of MSK ultrasound and paediatric patients into this service could be beneficial but not without undertaking further training. With appropriate funding and support the ICATS service has the potential to expand the clinical services it offers to general practice, helping to reduce work pressures in primary care at this time of crisis for UK general practice.
Healthcare-seeking behaviour in case of influenza-like illness in the French general population and factors associated with a GP consultation: an observational prospective study
Authors: Ariza Matthieu , Guerrisi Caroline , Souty Cécile , Rossignol Louise , Turbelin Clément , Hanslik Thomas , Colizza Vittoria , Blanchon Thierry 
Published: December 2017

BackgroundGP consultation rates for influenza-like illness (ILI) are poorly known in France and there is a paucity of literature on this topic. In the few articles that have been published, the results are heterogeneous.AimThe aim of the present study was to estimate the proportion of ILI inducing a GP consultation, and to assess its determinants.Design & settingParticipants of a French web-based cohort study who reported ≥1 ILI episode between 2012 and 2015 were included. Sociodemographic characteristics, access to health care, and health status variables were collected.MethodHealthcare-seeking behaviour was analysed and factors associated with a GP consultation identified using a conditional logistic regression.ResultsOf the 6023 ILI episodes reported, 1961 (32.6%) led to a GP consultation, with no difference between those at risk of influenza complications and those not (P = 0.42). A GP consultation was more frequent for individuals living in a rural area (odds ratio [OR] = 1.21, 95% confidence interval [CI] = 1.02 to 1.43); those with a lower educational level (OR = 1.43, 95% CI = 1.18 to 1.74); those using the internet to find information about influenza (OR = 1.63, 95% CI = 1.30 to 2.03); patients presenting with worrying symptoms (fever, cough, dyspnoea, sputum, or asthenia); patients having a negative perception of their own health status (OR = 1.51, 95% CI = 1.07 to 2.13; and those having declared a personal doctor (OR = 2.86, 95% CI = 1.72 to 4.76). A GP consultation was less frequent for individuals using alternative medicine (OR = 0.68, 95% CI = 0.58 to 0.78).ConclusionThis study allows the identification of specific factors associated with GP consultation for an ILI episode. These findings may help to coordinate health information campaigns and to raise awareness, especially among individuals at risk of influenza complications.
Chronologie et mutations fonctionnelles dans la poterie-tuilerie médiévale de la Goulande (La Haute-Chapelle, Orne)
Authors: Fajal Bruno , Gallet Yves , Lanos Philippe , Le Goff Maxime 
Published: December 2017

L’atelier de la Goulande (La Haute-Chapelle, Orne)
se trouve au sein d’un vaste ensemble de fosses d’extraction d’argiles
utilisées pour fabriquer de la poterie commune, des grès et des
tuiles. Les prospections géophysiques menées à cet endroit ont permis
de distinguer deux anomalies magnétiques, correspondant à trois fours
référencés A, B et C. Le premier (A) est un four à pots longitudinal,
daté par une analyse archéomagnétique de la seconde moitié du xiiie siècle ou du début du
xive siècle. Sa
morphologie et les productions qu’on peut lui associer sont proches de
celles de l’atelier voisin de Saint-Georges-de-Rouelley, dont le
réexamen des données archéomagnétiques recueillies au milieu des
années 1980 conduit à une datation plus haute d’un demi-siècle
(1260-1280 au lieu de 1325-1350). Les deux ateliers de potiers
(Saint-Georges-de-Rouelley et four A de la Goulande) seraient donc
sensiblement contemporains. À environ 1,50 m plus à l’est, se trouvent
les restes des deux autres fours. Le premier (B) est un four à tuiles,
auquel s’est substitué un four à pots longitudinal (C). En accord avec
les données archéologiques, les résultats archéomagnétiques obtenus
donnent des datations différentes pour chacun des fours étudiés. La
production de tuiles qui s’y est développée a probablement pris fin au
début du xve siècle.
Finalement, une production de grès s’est substituée à la production de
tuiles, vraisemblablement jusqu’au dernier tiers du xve siècle.
Primary synchronous small and non-small cell lung cancer in the same lung lobe: A case report
Authors: Dzian Anton , Ivan FÃºÄela , Zdenko HuÅ¥ka , Peter SzÃ©pe 
Published: December 2017

Synchronous multiple primary lung cancer (SMPLC) means tumours present at the same time, which are separate and have different histology. We present the case of a 66-year-old patient with a combination of small-cell lung carcinoma (SCLC) with adenocarcinoma in the same lobe with metastasis of SCLC in the mediastinal lymph node. This is aÂ rare case. We performed a standard left upper video-assisted thoracoscopic lobectomy with mediastinal lymphadenectomy and adjuvant therapy targeted to SCLC was administered. Despite advances in imaging methods and diagnostic procedures in pneumology a diagnosis of SMPLC is often discovered only intraoperatively or accidentally during the histological examination. Actually, no guidelines exist for the treatment protocol of such cases. Multiple methods of management of SMPLC, mainly complete anatomical resection with lymphadenectomy combined with chemotherapy or radiotherapy should be adopted according to the histologic types, staging and molecular testing of the tumours. These rare cases of SMPLC require individual treatment and multidisciplinary approach.Â