bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways
Authors: Zhang Yang , Wang Jing-Hao , Zhang Yi-Yuan , Wang Ying-Zhe , Wang Jin , Zhao Yue , Jin Xue-Xin , Xue Gen-Long , Li Peng-Hui , Sun Yi-Lin , Huang Qi-He , Song Xiao-Tong , Zhang Zhi-Ren , Gao Xu , Yang Bao-Feng , Du Zhi-Min , Pan Zhen-Wei 
Published: March 2016

AbstractInterleukin 6 (IL-6) has been shown to be an important regulator of cardiac interstitial fibrosis. In this study, we explored the role of interleukin-6 in the development of diabetic cardiomyopathy and the underlying mechanisms. Cardiac function of IL-6 knockout mice was significantly improved and interstitial fibrosis was apparently alleviated in comparison with wildtype (WT) diabetic mice induced by streptozotocin (STZ). Treatment with IL-6 significantly promoted the proliferation and collagen production of cultured cardiac fibroblasts (CFs). High glucose treatment increased collagen production, which were mitigated in CFs from IL-6 KO mice. Moreover, IL-6 knockout alleviated the up-regulation of TGFβ1 in diabetic hearts of mice and cultured CFs treated with high glucose or IL-6. Furthermore, the expression of miR-29 reduced upon IL-6 treatment, while increased in IL-6 KO hearts. Overexpression of miR-29 blocked the pro-fibrotic effects of IL-6 on cultured CFs. In summary, deletion of IL-6 is able to mitigate myocardial fibrosis and improve cardiac function of diabetic mice. The mechanism involves the regulation of IL-6 on TGFβ1 and miR-29 pathway. This study indicates the therapeutic potential of IL-6 suppression on diabetic cardiomyopathy disease associated with fibrosis.
The Empathizing-Systemizing Theory, Social Abilities, and Mathematical Achievement in Children
Authors: Escovar Emily , Rosenberg-Lee Miriam , Uddin Lucina Q. , Menon Vinod 
Published: March 2016

AbstractThe Empathizing-Systemizing (E-S) theory describes a profile of traits that have been linked to autism spectrum disorders, and are thought to encompass a continuum that includes typically developing (TD) individuals. Although systemizing is hypothesized to be related to mathematical abilities, empirical support for this relationship is lacking. We examine the link between empathizing and systemizing tendencies and mathematical achievement in 112 TD children (57 girls) to elucidate how socio-cognitive constructs influence early development of mathematical skills. Assessment of mathematical achievement included standardized tests designed to examine calculation skills and conceptual mathematical reasoning. Empathizing and systemizing were assessed using the Combined Empathy Quotient-Child (EQ-C) and Systemizing Quotient-Child (SQ-C). Contrary to our hypothesis, we found that mathematical achievement was not related to systemizing or the discrepancy between systemizing and empathizing. Surprisingly, children with higher empathy demonstrated lower calculation skills. Further analysis using the Social Responsiveness Scale (SRS) revealed that the relationship between EQ-C and mathematical achievement was mediated by social ability rather than autistic behaviors. Finally, social awareness was found to play a differential role in mediating the relationship between EQ-C and mathematical achievement in girls. These results identify empathy, and social skills more generally, as previously unknown predictors of mathematical achievement.
Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1
Authors: Cui Xu , Wang Shaojie , Cai Heguo , Lin Yuan , Zheng Xinpeng , Zhang Bing , Xia Chun 
Published: March 2016

AbstractOsteoarthritis (OA) is a degenerative disease characterized by deterioration of articular cartilage. Recent studies have demonstrated the importance of some microRNAs in cartilage damage. The aim of this study was to identify and characterize the expression of microRNA-634 (miR-634) in normal and OA chondrocytes, and to determine its role in OA pathogenesis. Human normal and OA chondrocytes obtained from patients were cultured in vitro. Transfection with miR-634 mimic or inhibitor was employed to investigate the effect of miR-634 on chondrocyte survival and matrix synthesis, and to identify miR-634 target. The results indicated that miR-634 was expressed at lower level in high grade OA chondrocyte compared with normal chondrocytes. Overexpression of miR-634 could inhibit cell survival and matrix synthesis in high grade OA chondrocytes. Furthermore, miR-634 targeted PIK3R1 gene that encodes the regulatory subunit 1 of class I PI3K (p85α) and exerted its inhibitory effect on the phosphorylation of Akt, mTOR, and S6 signal molecules in high grade OA chondrocytes. Therefore, the data suggested that miR-634 could suppress survival and matrix synthesis of high grade OA chondrocytes through targeting PIK3R1 gene to modulate the PI3K/Akt/S6 and PI3K/Akt/mTOR/S6 axes, with important implication for validating miR-634 as a potential target for OA therapy.
Visual straight-ahead preference in saccadic eye movements
Authors: Camors Damien , Trotter Yves , Pouget Pierre , Gilardeau Sophie , Durand Jean-Baptiste 
Published: March 2016

AbstractOcular saccades bringing the gaze toward the straight-ahead direction (centripetal) exhibit higher dynamics than those steering the gaze away (centrifugal). This is generally explained by oculomotor determinants: centripetal saccades are more efficient because they pull the eyes back toward their primary orbital position. However, visual determinants might also be invoked: elements located straight-ahead trigger saccades more efficiently because they receive a privileged visual processing. Here, we addressed this issue by using both pro- and anti-saccade tasks in order to dissociate the centripetal/centrifugal directions of the saccades, from the straight-ahead/eccentric locations of the visual elements triggering those saccades. Twenty participants underwent alternating blocks of pro- and anti-saccades during which eye movements were recorded binocularly at 1 kHz. The results confirm that centripetal saccades are always executed faster than centrifugal ones, irrespective of whether the visual elements have straight-ahead or eccentric locations. However, by contrast, saccades triggered by elements located straight-ahead are consistently initiated more rapidly than those evoked by eccentric elements, irrespective of their centripetal or centrifugal direction. Importantly, this double dissociation reveals that the higher dynamics of centripetal pro-saccades stem from both oculomotor and visual determinants, which act respectively on the execution and initiation of ocular saccades.
LTE‐A compliant multi‐band radio and gigabit/s baseband transmission over 50 m of 1 mm core diameter GI‐POF for in‐home networks
Authors: Forni F. , Shi Y. , van den Boom H.P.A. , Tangdiongga E. , Koonen A.M.J. 
Published: March 2016

The transmission of multiple standard‐compliant long‐term evolution advance (LTE‐A) bands together with a 4‐pulse amplitude modulation (PAM) baseband signal over 50‐m‐long 1 mm core diameter polymethyl methacrylate graded‐index plastic optical fibre is demonstrated. Transmission of eight LTE‐A 64‐QAM bands and a 1.2 Gbit/s 4‐PAM baseband signal over the fibre was achieved resulting in an error vector magnitude <8% and pre‐forward error correction (FEC) BER < 10−3, respectively.
Infrared spectral normal emittance/emissivity comparison
Authors: Hanssen L , Wilthan B , Filtz J -R , Hameury J , Girard F , Battuello M , Ishii J , Hollandt J , Monte C 
Published: March 2016

The National Measurement Institutes (NMIs) of the United States, Germany, France, Italy and Japan, have joined in an inter-laboratory comparison of their infrared spectral emittance scales. This action is part of a series of supplementary inter-laboratory comparisons (including thermal conductivity and thermal diffusivity) sponsored by the Consultative Committee on Thermometry (CCT) Task Group on Thermophysical Quantities (TG-ThQ). The objective of this collaborative work is to strengthen the major operative National Measurement Institutes' infrared spectral emittance scales and consequently the consistency of radiative properties measurements carried out worldwide. The comparison has been performed over a spectral range of 2 μm to 14 μm, and a temperature range from 23 °C to 800 °C. Artefacts included in the comparison are potential standards: oxidized Inconel, boron nitride, and silicon carbide. The measurement instrumentation and techniques used for emittance scales are unique for each NMI, including the temperature ranges covered as well as the artefact sizes required. For example, all three common types of spectral instruments are represented: dispersive grating monochromator, Fourier transform and filter-based spectrometers. More than 2000 data points (combinations of material, wavelength and temperature) were compared. Ninety-eight percent (98%) of the data points were in agreement, with differences to weighted mean values less than the expanded uncertainties calculated from the individual NMI uncertainties and uncertainties related to the comparison process.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCT, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Co-designing social marketing programs
Authors: Dietrich Timo , Rundle-Thiele Sharyn , Schuster Lisa , Connor Jason 
Published: March 2016

Purpose
– Most alcohol education programs are designed by experts, with the target audience largely excluded from this process. Theoretically, application of co-creation which comprises co-design and co-production offers an opportunity to better orient programs to meet audience needs and wants and thereby enhance program outcomes. To date, research has centered on value co-creation, with content co-design receiving limited research attention. This study aims to understand how a target audience would design an intervention and continues by contrasting an audience-designed program with the earlier implemented expert-designed program.

Design/methodology/approach
– Six co-design sessions were conducted with 58 Year 10 adolescents, aged between 14-16 years old, who had participated in Game On: Know Alcohol, a program developed by experts to address binge drinking. The data were content analyzed.

Findings
– Analysis revealed that a co-designed program would differ substantially from the expert-driven Game On: Know Alcohol program recently trialed. The results indicate that adolescents prefer interactive activities that engage and challenge. Three alternative program solutions, catering to identified segments in the target audience, are suggested for future implementation and evaluation.

Research limitations/implications
– This sample is limited to adolescents from Catholic schools in one state of Australia, and future research is recommended to extend findings beyond this group. This study is limited to establishment of audience (adolescent) preferences, and future experimental field research is needed to develop, implement and evaluate a co-designed program.

Originality/value
– This study details a co-design process highlighting differences between expert-designed and audience-designed programs. Future research investigating whether a co-designed program will deliver superior outcomes to an expert-designed program is recommended.
Knowledge management for library building design
Authors: Yi Zhixian 
Published: March 2016

Purpose
– In the digital age, constant changes in libraries inform contemporary building design. An innovative library building design is a complicated process and can be viewed as a continuous process of the use of tacit and explicit knowledge and innovative tools and approaches. Knowledge management (KM) can bring about the much needed innovation, and transform tacit knowledge to explicit knowledge. For the design of a library to be successful, it is necessary to apply KM to library building design. The purpose of this paper is to look at key change impacts, to explore how to manage knowledge in building design and to identify key design principles.

Design/methodology/approach
– This paper looks at key change impacts, explores how to manage knowledge in library building design and pinpoints design principles.

Findings
– This paper finds that KM can be vital to library building design, and it can be used in all stages: to examine the internal and external environments, transform tacit knowledge to explicit knowledge by using portals, and analyze existing and future issues and trends. When effectively used, KM will result in innovative design strategies and also will reduce the time and costs of the building design and plan processes. The main principles of library building design are flexibility, accessibility, safety and security, applicability, adaptability, efficiency, and sustainability.

Practical implications
– This paper provides a useful overview of how to manage knowledge in library building design and design principles.

Originality/value
– The views, discussions, and suggestions will be of value to improve the effectiveness of library building design.
Development of accounting standards in selected Middle Eastern countries in comparison to the United States of America
Authors: Aghimien Peter A 
Published: March 2016

Purpose
– The purpose of this paper is to compare the development of accounting standards in five diverse Middle Eastern countries with those of the USA.

Design/methodology/approach
– A comparative analysis of each country with what is obtained in the USA.

Findings
– While there are some similarities that influence the development of accounting standards in each country, there also exist a variety of differences, particularly in the areas of taxation, use of International Financial Reporting Standards (IFRS), religion, population and so on.

Research limitations/implications
– The findings are limited to the five countries analyzed. Future research may want to expand the number of Middle Eastern countries included in the population studied.

Originality/value
– The study is original particularly due to the diversity of the countries selected. While the USA is an economically and technologically developed country, almost all of the other countries could be classified as developing. Additionally, the USA is the only country with its own uniquely developed standards, which are universally respected, but different from the single set of high-quality standards commonly referred to as the IFRS, which more than 100 countries have adopted.
The wound/burn guidelines – 4: Guidelines for the management of skin ulcers associated with connective tissue disease/vasculitis
Authors: Fujimoto Manabu , Asano Yoshihide , Ishii Takayuki , Ogawa Fumihide , Kawakami Tamihiro , Kodera Masanari , Abe Masatoshi , Isei Taiki , Ito Takaaki , Inoue Yuji , Imafuku Shinichi , Irisawa Ryokichi , Ohtsuka Masaki , Ohtsuka Mikio , Kadono Takafumi , Kawaguchi Masakazu , Kukino Ryuichi , Kono Takeshi , Sakai Keisuke , Takahara Masakazu , Tanioka Miki , Nakanishi Takeshi , Nakamura Yasuhiro , Hashimoto Akira , Hasegawa Minoru , Hayashi Masahiro , Fujiwara Hiroshi , Maekawa Takeo , Matsuo Koma , Madokoro Naoki , Yamasaki Osamu , Yoshino Yuichiro , Le Pavoux Andres , Tachibana Takao , Ihn Hironobu ,   The Wound/Burn Guidelines Committee
Published: March 2016

AbstractThe Japanese Dermatological Association prepared guidelines focused on the treatment of skin ulcers associated with connective tissue disease/vasculitis practical in clinical settings of dermatological care. Skin ulcers associated with connective tissue diseases or vasculitis occur on the background of a wide variety of diseases including, typically, systemic sclerosis but also systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid arthritis (RA), various vasculitides and antiphospholipid antibody syndrome (APS). Therefore, in preparing the present guidelines, we considered diagnostic/therapeutic approaches appropriate for each of these disorders to be necessary and developed algorithms and clinical questions for systemic sclerosis, SLE, dermatomyositis, RA, vasculitis and APS.
Relationship between prior knowledge about herpes zoster and the period from onset of the eruption to consultation in patients with herpes zoster
Authors: Miyachi Motoko , Imafuku Shinichi 
Published: March 2016

AbstractHerpes zoster (HZ) is a common internal infection caused by latent varicella zoster virus. Emergence of antiviral chemotherapy has changed the treatment of HZ dramatically, but the effects of such therapy are documented only in patients who started treatment within 72 h of HZ onset of the eruption. There have been few studies addressing the question of factors that determine early attendance of patients at a clinic. We questioned 256 patients with acute HZ about: (i) date from onset of the eruption to first clinic visit; and (ii) their prior knowledge of HZ. We found a tendency that patients who already knew about HZ had consulted dermatology clinics earlier (P < 0.05). People most commonly obtained information about the disease from friends and family members who had previously had HZ, but not from the Internet or other mass media. Our results indicate that patient education is important for early attendance at dermatology clinics, which in turn, should result in the improved outcome of antiviral chemotherapy and prevention of postherpetic neuralgia.
A test of the effects of timing of a pulsed resource subsidy on stream ecosystems
Authors: Sato Takuya , El‐Sabaawi Rana W. , Campbell Kirsten , Ohta Tamihisa , Richardson John S. 
Published: March 2016

Summary

Spatial resource subsidies can alter bottom‐up and top‐down forces of community regulation across ecosystem boundaries. Most subsidies are temporally variable, and recent theory has suggested that consumer‐resource dynamics can be stabilized if the peak timing of a subsidy is desynchronized with that of prey productivity in the recipient ecosystem. However, magnitude of consumer responses per se could depend on the subsidy timing, which may be a critical component for community dynamics and ecosystem processes.

The aim of this study was to test (i) whether a recipient consumer (cutthroat trout) responds differently to a resource subsidy occurring early in its growing season than to a subsidy occurring late in the season and, if this is the case, (ii) whether the timing‐dependent consumer response has cascading effects on communities and ecosystem functions in streams.

To test those hypotheses, we conducted a large‐scale field experiment, in which we directly manipulated the timing of augmentation of the terrestrial invertebrates that enter stream (i.e. peak timing of June–August vs. August–October), keeping constant the total amounts of the invertebrates entered.

We found large increases in the individual growth rate and population biomass of the cutthroat trout, in response to the early resource pulse, but not to the late pulse. This timing‐dependent consumer response cascaded down to reduce benthic invertebrates and leaf breakdown rate, and increased water nutrient concentrations. Furthermore, the early resource pulse resulted in higher maturity rate of the cutthroat trout in the following spring, demonstrating the importance of the subsidy timing on long‐term community dynamics via the consumer's numerical response.

Our results emphasize the need to acknowledge timing‐dependent consumer responses in understanding the effects of subsidies on communities and ecosystem processes. Elucidating the mechanisms by which consumers effectively exploit pulsed subsidies is an important avenue to better understand community dynamics in spatially coupled ecosystems.
Structured promotion of breastmilk expression is associated with shortened hospitalisation for very preterm infants
Authors: Healy David B. , Brennan Ann‐Marie , O'Donovan Rebecca , Daly Veronica , Doolan Anne , Dempsey Eugene M. 
Published: March 2016

AbstractAimThis study assessed neonatal outcomes following implementation of a structured, practical approach for promotion of breastmilk expression in mothers of very preterm infants.MethodsA multidisciplinary team developed a protocol that focussed on the enhancement of expression of human milk by mothers of very preterm infants. A pre‐ and poststudy intervention was subsequently performed. The group of infants enrolled in this time period was compared to a pre‐intervention group from 2010. Outcomes assessed included breastmilk expression, initiation of feeding, re‐attainment of birthweight, attainment of full enteral feeding, the incidence of necrotising enterocolitis (NEC), sepsis and duration of hospitalisation.ResultsIn total, 82 infants (39,43) were included. While there was no statistically significant difference in earlier initiation of enteral feeding with EBM (median = 2 days) nor earlier achievement of fully enteral feeding (median = 12 days), birthweight was regained earlier in the postintervention cohort (mean = 10.42 days; p = 0.038) and there was a reduced length of stay (mean = 50 days; p = 0.021).ConclusionA structured, focussed, multimodal approach to enhance breastmilk production has shown potential for producing positive end outcomes, particularly, a significant reduction in duration of hospitalisation.
Sézary‐Syndrom: von ungelösten Fragen zu neuen Therapieansätzen
Authors: Nicolay Jan P. , Felcht Moritz , Schledzewski Kai , Goerdt Sergij , Géraud Cyrill 
Published: March 2016

ZusammenfassungDas Sézary‐Syndrom, die leukämische Variante des kutanen T‐Zell‐Lymphoms, stellt immer noch eine Erkrankung mit vielen ungelösten Fragen sowie einer sehr ungünstigen Prognose dar. In jüngeren Forschungsarbeiten wurde jedoch eine Vielzahl an fehlregulierten molekularen Signalwegen identifiziert, die zur malignen Transformation und Therapieresistenz von Sézary‐Zellen (SC) beitragen. Im Hinblick auf die T‐Zell‐Entwicklung repräsentieren SC entweder naive T‐Zellen, T‐Effektor‐Gedächtniszellen oder zentrale T‐Gedächtniszellen. Funktionell können SC in Th2‐, Treg‐ oder sogar Th17‐Zellen differenzieren. Trotz ihrer Plastizität exprimieren SC charakteristische diagnostische Markerproteine, darunter CD158k, CD164, FcRL3, und PD‐1, sowie Haut‐spezifische Homing‐Rezeptoren wie CLA und CCR4. Wie bereits in (vor)klinischen Studien getestet, sind CD158k, PD‐1, CTLA‐4 und CCR4 auch vielversprechende therapeutische Zielmoleküle. Die molekularen Veränderungen bei SC betreffen Transkriptionsfaktoren wie STAT3, 4 und 5 sowie TWIST1 und TOX. TWIST1 induziert die Expression von DNM3os, das den miR‐199a2/214‐Cluster enthält, ein wichtiger Knotenpunkt, über den viele verschiedene Krebs‐Netzwerke reguliert werden. Darüber hinaus verursacht die Aktivierung von NFκB und des MAPK‐Signalwegs sowie eine veränderte TCR‐Signalgebung Resistenz gegenüber Apoptose. Kürzlich wurde durch Genom‐ und Exomsequenzierung gezeigt, dass somatische Variationen der Kopienzahl die vorherrschenden Mutationen bei SC darstellen, wodurch vor allem Apoptose, NFκB‐Signalgebung, DNA‐Integrität und T‐Zell‐Aktivierung beeinflusst werden. Um die Entwicklung neuer Therapien zu ermöglichen, wird zurzeit an besseren In‐vivo‐Modellen gearbeitet, die die Pathogenese und den klinischen Verlauf des Sézary‐Syndroms genauer widerspiegeln.