bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oncolytic virus-induced cell death and immunity: a match made in heaven?
Authors: De Munck Jolien , Binks Alex , McNeish Iain A , Aerts Joeri L 
Published: July 2017

Abstract
Our understanding of the mechanisms responsible for cancer development has increased enormously over the last decades. However, for many cancers, this has not been translated into a significant improvement in overall survival, and overall mortality remains high. Treatment for many malignancies remains based on surgery, chemotherapy, and radiotherapy. Significant progress has been made toward the development of more specific, more potent, and less invasive treatment modalities, but such targeted therapies remain the exception for most cancers. Thus, cancer therapies based on a different mechanism of action should be explored. The immune system plays an important role in keeping tumor growth at bay. However, in many cases, these responses are not strong enough to keep tumor growth under control. Thus, immunotherapy aims to boost the immune system to suppress tumor growth efficiently. This has been demonstrated by the recent successes of immune checkpoint therapy in several cancers. Oncolytic viruses (OVs) are another exciting class of immunotherapy agent. As well as replicating selectively within and killing tumor cells, OVs are able to elicit potent anti-tumor immune responses. Therapeutic vaccination with OVs, also referred to as cancer virotherapy, can thus be tailored to elicit vigorous cellular immune responses and even target individual malignancies in a personalized manner. In this review, we will describe the intricate link among oncolytic virotherapy, tumor immunology, and immunogenic cell death (ICD) and discuss ways to harness optimally their potential for future cancer therapy.
Framework Agreements in Procurement: An Auction Model and Design Recommendations
Authors: Gur Yonatan , Lu Lijian , Weintraub Gabriel Y. 
Published: July 2017

Framework agreements (FAs) are procurement mechanisms commonly used by buying agencies around the world to satisfy demand that arises over a certain time horizon. This paper is one of the first in the literature that provides a formal understanding of FAs, with a particular focus on the cost uncertainty bidders face over the FA time horizon. We generalize standard auction models to include this salient feature of FAs and analyze this model theoretically and numerically. First, we show that FAs are subject to a sort of winner’s curse that in equilibrium induces higher expected buying prices relative to running first-price auctions as needs arise. Then, our results provide concrete design recommendations that alleviate this issue and decrease buying prices in FAs, highlighting the importance of (i) monitoring the price charged at the open market by the FA winner to bound the buying price; (ii) implementing price indexes for the random part of suppliers’ costs; and (iii) allowing suppliers the flexibility to reduce their prices to compete with the open market throughout the selling horizon. These prescriptions are already being used by the Chilean government procurement agency that buys US$2 billion worth of contracts yearly using FAs. The online appendix is available at https://doi.org/10.1287/msom.2017.0623 .
Re-using blood products as an alternative supplement in the optimisation of clinical-grade adipose-derived mesenchymal stem cell culture
Authors: Phetfong J. , Tawonsawatruk T. , Seenprachawong K. , Srisarin A. , Isarankura-Na-Ayudhya C. , Supokawej A. 
Published: July 2017

Objectives Adipose-derived mesenchymal stem cells (ADMSCs) are a promising strategy for orthopaedic applications, particularly in bone repair. Ex vivo expansion of ADMSCs is required to obtain sufficient cell numbers. Xenogenic supplements should be avoided in order to minimise the risk of infections and immunological reactions. Human platelet lysate and human plasma may be an excellent material source for ADMSC expansion. In the present study, use of blood products after their recommended transfusion date to prepare human platelet lysate (HPL) and human plasma (Hplasma) was evaluated for in vitro culture expansion and osteogenesis of ADMSCs. Methods Human ADMSCs were cultured in medium supplemented with HPL, Hplasma and a combination of HPL and Hplasma (HPL+Hplasma). Characteristics of these ADMSCs, including osteogenesis, were evaluated in comparison with those cultured in fetal bovine serum (FBS). Results HPL and HPL+Hplasma had a significantly greater growth-promoting effect than FBS, while Hplasma exhibited a similar growth-promoting effect to that of FBS. ADMSCs cultured in HPL and/or Hplasma generated more colony-forming unit fibroblasts (CFU-F) than those cultured in FBS. After long-term culture, ADMSCs cultured in HPL and/or Hplasma showed reduced cellular senescence, retained typical cell phenotypes, and retained differentiation capacities into osteogenic and adipogenic lineages. Conclusion HPL and Hplasma prepared from blood products after their recommended transfusion date can be used as an alternative and effective source for large-scale ex vivo expansion of ADMSCs. Cite this article: J. Phetfong, T. Tawonsawatruk, K. Seenprachawong, A. Srisarin, C. Isarankura-Na-Ayudhya, A. Supokawej. Re-using blood products as an alternative supplement in the optimisation of clinical-grade adipose-derived mesenchymal stem cell culture. Bone Joint Res 2017;6:414–422. DOI: 10.1302/2046-3758.67.BJR-2016-0342.R1.
Untersuchung des Entscheidungsverhaltens in kooperativen
Verkehrssituationen am Beispiel einer Engstelle
Authors: Imbsweiler Jonas , Palyafári Renáta , Puente León Fernando , Deml Barbara 
Published: July 2017

Zusammenfassung
Eine der zukünftigen Herausforderungen, um einen erfolgreichen
Mischverkehr zwischen automatisch geführten und von Menschen
geführten Fahrzeugen zu bewältigen, ist, dass in kooperativen
Situationen – z. B. an einer gleichrangigen Engstelle – die
Teilnehmer am Straßenverkehr das Fahrverhalten des Gegenübers
verstehen. Eine der Fragen, die Färber
Färber, B.
(2015). Kommunikationsprobleme zwischen autonomen
Fahrzeugen und menschlichen Fahrern. In: M. Maurer, J. C. Gerdes, B. Lenz & H. Winner
(Hrsg.), Autonomes Fahren. Technische, rechtliche und gesellschaftliche
Aspekte. Berlin: Springer Vieweg.
aufwirft, ist, ob
Menschen in der Lage sind, schwierige kooperative Situationen mit
automatisch geführten Autos zu bewältigen. Im täglichen
Straßenverkehr haben Verkehrsteilnehmer die Möglichkeit, sich
per expliziter oder impliziter Kommunikation an eine Engstelle zu
nähern und so dem Gegenüber die eigene Intention zu
vermitteln. In einem Quasi-Experiment (N = 22) wurden verschiedene
Annäherungsweisen an eine gleichrangige Engstelle untersucht und
u. a. das Entscheidungsverhalten sowie das Kommunikationsverhalten
analysiert, um Rückschlüsse darüber ziehen zu können,
wie sich automatisch geführte Autos in einer solchen Situation
verhalten sollten. Auf diese Weise sollen die Verhaltensweisen
herausgefiltert werden, die es ermöglichen, eine schwierig zu
lösende Situation für beide Verkehrsteilnehmer adäquat zu
bewältigen.
Modern energetics: current problems in energy conversion and utilization of produced energy
Authors: Alfimov Michail V. , Razumov Vladimir F. 
Published: July 2017

Abstract
In this study, we discussed the state-of-art in global energy industry in a historical retrospective and the forecast of its development for the next 25 years. At least in the nearest quarter of a century, the main source of primary energy will remain the chemical energy of different hydrocarbon fuels, including natural gas, coal, oil, and biofuels. In this context, of current importance becomes the problem of more rational utilization of produced energy. We analyzed the basic physical constraints that define a maximum efficiency of energy conversion and utiliztion of primary energy sources.
Slovenia. Occupation, Repression, Partisan Movement, Collaboration, and Civil War in Historical Research
Authors: Troha Nevenka 
Published: July 2017

Abstract
The author discusses recent Slovenian historiography on the Second World War, establishing that numerous high quality works were written before 1990, and before the breakup of Yugoslavia. These works, however, put the history of the liberation struggle into the foreground. In the 1980s, historians started to research several topics that had previously gone unstudied. This decade saw a process of democratization in Slovenia, and new archival materials became accessible. Scholars researching the war after 1990 can be roughly divided into three camps: those with a continued interest in the liberation movement and the partisan war; those who take an apologetic stance towards the issue of collaboration, maintaining that the war in the Slovenian lands was first of all a civil war that had been initiated by the communists; and, finally, those who have asked new questions and explored them in such a way that have put them at eye-level with European standards of scholarship.
Crystal structure and theoretical investigation of bis(cis-1,2-diaminocyclohexane)zinc(II) tetrachloridozincate(II)
Authors: Akhtar Muhammad , Zierkiewicz Wiktor , Michalczyk Mariusz , Rüffer Tobias , Lang Heinrich , Isab Anvarhusein A. , Mazhar Muhammad , Ahmad Saeed 
Published: July 2017

Abstract
A zinc(II) complex of cis-1,2-diaminocyclohexane (Dach), [Zn(Dach)2][ZnCl4] (1), was prepared and its structure was determined by X-ray crystallography. Theoretical (density functional theory) studies were performed for the two model compounds, [Zn(Dach)2][ZnCl4] (1) and {[Zn(Dach)2][ZnCl4]}3 (1

3
). The structure of complex 1 is composed of [Zn(Dach)2]2+ cations and [ZnCl4]2− anions. The Zn1 atom in the cationic complex adopts a severely distorted tetrahedral geometry, while in the anionic part, Zn2 displays only a slight distortion from tetrahedral coordination. The adjacent cations and anions are associated with each other through hydrogen bonding interactions to form a two-dimensional network in the solid state.
The Effect of Physical Activity Agains The Telomere Length in The Leukocytes Cells of KONI (Indonesian National Sports Committee) Athletes
Authors: Purwaningsih Endang , Djannatun Titiek , Widayanti Etty , Suciati Yulia , Zulhamidah Yenni 
Published: July 2017

<p><br /> Telomeres are strands of non coding DNA at the ends of chromosomes that have the primary function to protect DNA from damage and maintain chromosomal stability. Physical exercise will increase the antioxidant activity can increase telomere proteins, lengthen telomeres and or protein networks associated with telomere so that the telomere remains long, or stopping telomere shortening. Telomere length was also associated with age. The purpose of the research was to determine telomere length of leukocyte cells in the KONI athletes in Jakarta,<br /> The research method is descriptive, by measuring telomere length using quantitative PCR on leukocyte cells. Samples are KONI athletes from several sports, including men and women athletes, with ages between 15-20 years. Used a control group (not athletes) is students of the Faculty of Medicine, University of YARSI. The results showed that there was no significant difference (p&gt; 0.05) between telomere length group of athletes with the control group in both sexes. Similarly, telomere length between athlete male with female athletes also showed no significant difference (p&gt; 0.05). It was concluded that physical exercise in athletes KONI at the age of 15- 20 years had no effect on telomere length in leukocytes. The results of this study provide information about the telomere length in Indonesian athletes at an early age</p>
Diversity and Distribution of Myrmecophytes in Bengkulu Province
Authors: Safniyeti Safniyeti , Sulistijorini Sulistijorini , Chikmawati Tatik 
Published: July 2017

<p>Myrmecophyte is a common medicinal plant used by local people in Indonesia for treating various diseases especially in Papua. Bengkulu province is one of the myrmecophyte habitats, but there has no report on its identity and distribution. The objectives of this research were to identify the diversity and analyze the myrmecophytes distribution as well as factor affecting its presence. This study used purposive sampling method by exploring the area where myrmecophytes commonly found. The myrmecophyte distribution was analyzed using <em>Morishita</em> index and <em>Arcgis</em> 10.1, and the autecological analysis of abiotic factors was performed using <em>Principal Component Analysis</em> (PCA) generated from Minitab 16. The results of this research showed that there were two species of myrmecophytes in Bengkulu province, namely <em>Hydnophytum formicarum</em> and <em>Myrmecodia tuberosa</em>, as well as two variants of <em>M. tuberosa</em> i.e. <em>M. tuberosa</em> 'armata’ and <em>M. tuberosa</em> 'siberutensis'. The distribution of myrmecophytes was mostly randomly scattered in Central Bengkulu regency, Seluma, North Bengkulu, South Bengkulu, and Kaur. Their distributions were affected by light intensity and temperature. The data of this research can be used as basic information for carried out conservation efforts in Bengkulu province. The abundance of myrmecophytes is also used as a source of additional income for local people in Bengkulu province. </p>
Impact of transition on quality of life in patients with congenital adrenal hyperplasia diagnosed during childhood
Authors: Bachelot Anne , Vialon Magaly , Baptiste Amandine , Tejedor Isabelle , Elie Caroline , Polak Michel , Touraine Philippe , _ _ 
Published: July 2017

Background
Health-related quality of life (QoL) in adult patients with congenital adrenal hyperplasia (CAH) has been variously reported. However, there is no study evaluating the impact of transition on quality of life.

Methods
Adult patients with classic or non-classic CAH diagnosed during childhood CAH, born between 1970 and 1990, were recruited from the registers of Pediatric departments belonging to the French reference center for endocrine rare disease. Primary end point was the QoL (WHOQOL-BREF).

Results
Seventy-three patients were included in the study, among them 59/73 were transferred to adult endocrinologist by their pediatricians for transition. WHOQOL-BREF scores were similar between patients with or without transition to specialist adult services, except for environment dimension score, which was slightly higher in CAH patients without transition. However, CAH patients with a regular follow-up had a better physical health, psychological health and environment score and item global QoL than the group without regular follow-up after transition.

Conclusion
Regular medical follow-up in adulthood is associated with the transition between pediatric and adult care and is associated with better QoL in adults with CAH.
A novel computed tomography method to detect normal from abnormal psoas muscle: a pilot feasibility study
Authors: Patel Jayshil J , Baruah Dhiraj , Shahir Kaushik 
Published: July 2017

AbstractBackgroundSarcopenia is a syndrome characterized by progressive loss of skeletal muscle which can be detected by computed tomography (CT) by estimating total psoas muscle cross‐sectional area (CSA). Relying on total psoas CSA alone takes into account abnormal muscle and intramuscular fat, both of which may be increased in sarcopenic obesity. We developed a novel CT‐method to identify the proportion of normal to abnormal psoas muscle at the third lumbar (L3) level. The primary objective of our pilot study was to measure inter‐observer agreement between measuring total psoas CSA and proportion of normal and abnormal psoas muscle using a novel CT‐method. We hypothesized total psoas CSA and proportion of normal and abnormal psoas muscle would be reliably quantifiable.MethodsCT abdomen images were obtained for 20 adults. Two radiologists independently identified and traced the L3 psoas muscle circumference to estimate CSA. Hounsfield units were applied to the tracing to identify proportion of normal muscle, abnormal muscle, and fat. Inter‐observer agreement was assessed using Pearson's correlation coefficient.ResultsOf the 20 patients, 13 were male and six were obese. Mean age was 66 years. Correlation coefficient was excellent for total psoas CSA (r=0.93, p‐value<0.00001) and proportion of normal psoas muscle (r=0.94, p‐value<0.0001). Correlation was excellent between BMI and abnormal muscle (r=0.67, p‐value=0.001). Correlation was poor between total psoas CSA and body mass index (BMI) (r=0.369, p‐value=0.108) and negative between proportion of normal muscle and BMI (r= ‐0.50, p‐value=0.025).ConclusionsOur study findings demonstrate that total psoas CSA and proportion of normal and abnormal psoas can be reliably quantified. Our CT‐method may be superior to total psoas CSA in identifying sarcopenic obesity, the results of which can be used to explore clinical outcomes.
Correlation of prolonged fasting and gall bladder sludge formation after emergency G. I. surgery
Authors: Singh Shailendra Pal , Singh Pradeep Kumar , Singh Praveen , Verma Shashank , Tiwari Krishna Kumar 
Published: July 2017

Background: After emergency laparotomy due to some intestinal pathology patient are kept fasting to rest the bowel so that repaired pathology could get the proper time for healing. And during this period body’s nutritional requirement are replenished either by total parenteral nutrition or other intravenous fluids containing glucose and electrolytes. The major complication of TPN is liver disease that most commonly include steatosis, cholestasis, Cholelithiasis. Development of cholestasis, biliary sludge, and gall stone are due to loss of enteric stimulation and not directly linked to TPN. The effect of fasting on the composition of hepatic and gall bladder bile in humans has already been studied and this shows gall bladder bile is significantly supersaturated after fasting and can lead to sludge formation.Methods: A prospective study was conducted in department of general surgery, a rural tertiary care centre in north india (UPUMS, Saifai, Etawah, Uttar Pradesh, India) between January 2016 to May 2017. Study included all the patients in emergency who were planned for emergency laparotomy based on inclusion and exclusion criteria.Results: Of the 116 patients 83 (71.5%) were male patients and 33 (28.4%) were female patients, aged between (23 - 64 years). Total no. of sludge positive patients after 7 days was 39 (33.6%). Sludge positive female patients were 17 in 33 (51.1%) and sludge positive male patients were 22 out of 83 male patients (26.5%). Out of 53 patients of duodenal and gastric surgery 28 patients (52.8%) developed sludge formation. Out of other 63 surgeries only 10 (15.8%) patients developed sludge. Out of 39 sludge positive patients 28 (71.7%) were alone from group of duodenal and gastric surgery.Conclusions: our study supports that the prolonged restriction of oral food intake in patient operated on the gastrointestinal tract that results in decreased contractility due to absence of food stimulated gall bladder contraction, may be an important cause to sludge development in our group of patients.
Clinico sonological and laboratory co-relation with histopathology of acute appendicitis to develop new diagnostic scoring system (Yash scoring system)
Authors: Lamture Yashwant R. , Ramteke Harshal , Shinde R. K. , Shahapurkar Vinay V. , Gajbhiye Varsha P. 
Published: July 2017

Background: Of the many scoring systems currently available, the modified Alvarado scoring system (MASS) is the most widely employed, because of its ability to reduce negative appendectomy rate (NAR). Unfortunately, this system is more accurate in western population. In spite of the advances in the diagnostic and imaging techniques NAR have not decreased much. This clearly indicates the need of development of new diagnostic scoring system so we have developed new diagnostic scoring system (Yash Score). The objective of this study was to develop and study diagnostic accuracy of new diagnostic scoring system (Yash scoring system) for acute appendicitis.Methods: A prospective comparison YSS and MASS was done on 418 patients. Depending on clinical judgement appendicectomy was done. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy for YSS and MASS were calculated using SPSS 17.0 statistical software for statistical analysis and compared using Chi-square test.Results: The sensitivity and specificity of YSS was found to be 99.48 per cent and 92.86 percent respectively. The sensitivity and specify of MASS was 52.05 per cent and 100 per cent respectively. The positive predictive value and negative predictive value of YSS was 99.48 per cent and 92.86 per cent respectively. Negative and positive predictive values of MASS were 13.02% and 100% respectively.Conclusions: Comparison in between YSS and MASS in the present study shows significant statistical difference.
Clinicopathological profile, diagnosis and treatment of skin cancers at a tertiary care center: a retrospective study
Authors: Jina Abhishek , Singh Vineet , Saini Sunil , Chotan Neena , Rajan Manu 
Published: July 2017

Background: Majority of skin cancers are basal cell carcinoma, Squamous cell carcinoma and Malignant melanoma which account for more than 95% of total skin malignancies. There is an increase in incidence in India over some 10 years of period. This study was done for analysing clinicopathological profile of skin malignancies and association of human papilloma virus (HPV) in skin malignancies in Himalayan Institute of Medical Sciences (HIMS, Uttarakhand, India.Methods: It was a retrospective study done on 101 patients having malignant skin lesions attending the Department of Surgery at HIMS from October 2005 to October 2008 and given their consent.Results: Out of 101 patients, 68 had squamous cell carcinoma, 21 had basal cell carcinoma and 10 had malignant melanoma, prevalence is high in men of lower socioeconomic status (M:F) 1.9:1. The mean age was 54.50 years. Most of the patients were laborers, farmers and factory workers. Ulcers and ulceroproliferative growth were common mode of presentation. Most commonly associated risk factor was exposure to sunlight, the commonest location of skin cancer was face and scalp. Wide local excision was the commonest done procedure with closure of primary defect by SSG, fasciocutaneous or cutaneous flaps. No HPV association was seen.Conclusions: Skin cancers are quite common and their incidence has increased in last few decades, in this study we found that skin cancer were more common in males of lower socioeconomic status, probable cause was increased sun exposure and chemical exposure, in respect to females. Cancer could manifest in many forms but ulcers quite common, Squamous cell carcinoma outnumbered basal cell carcinoma, Wide local excision with skin grafts was main stay of treatment.