bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nostalgia for America's past can buffer collective guilt
Authors: Baldwin Matthew , White Mark H. , Sullivan Daniel 
Published: November 2017

AbstractThis research examined when, and for whom, American collective nostalgia can relieve feelings of collective guilt. In the Pilot Study, path analyses revealed that national glorification is associated with collective nostalgia, and collective nostalgia is associated with lower collective guilt. Our experimental studies test the role of these variables in determining responses to the elevated salience of past ingroup harm doing. Collective nostalgia was associated with lower collective guilt especially after reminders of America's harm doing in Study 1. In Study 2 we predicted and showed that reminders of American harm doing would evoke spontaneous collective nostalgia for participants high in national glorification. The remaining studies tested the hypothesis that collective nostalgia serves to buffer collective guilt. Collective guilt was lower after reminders of past harm doing for participants who engaged in collective nostalgia (Study 3), and this was especially pronounced for participants high in national glorification (Study 4).
Metallophthalocyanines Bearing Polymerizable {[5‐({(1E)‐[4‐(Diethylamino)phenyl]methylene}amino)‐ 1‐naphthy1]oxy} Groups as Electrochemical Pesticide Sensor
Authors: Akyüz Duygu , Keleş Turgut , Biyiklioglu Zekeriya , Koca Atıf 
Published: November 2017

AbstractThe synthesis and characterization of novel metallophthalocyanines (MPcs(ea)) carrying {[5‐({(1E)‐[4‐(diethylamino)phenyl]methylene}amino)‐1‐naphthyl]oxy} groups on four peripheral positions have been reported. These complexes have been characterized by a combination of FT‐IR, 1H and 13C NMR, mass and UV‐Vis spectroscopy techniques. Redox active metal centers in the core of the Pc rings (Co (II) [CoPc(ea)], Mn(III) [Cl–MnPc(ea)], and Ti(IV)O [TiOPc(ea)]) and electropolymerizable substituents on the peripheral positions of Pc rings were used to increase redox activity and electrochemically polymerization ability of the complexes. The redox properties of MPcs(ea) were determined with voltammetry and in situ spectroelectrochemistry techniques. Then, GCE/MPc(ea) electrodes were constructed with the electropolymerization of MPcs and these electrodes were tested as the pesticide sensors. Sensing studies indicated that type of the metal center of the complexes effectively influenced the sensing activities. While all complexes showed interaction abilities for the fenitrothion, parathion and eserine, GCE/CoPc(ea) electrode detected the parathion selectively with LOD value of 4.52×10−7 mol dm−3 among studied three pesticides. Moreover, GCE/MnClPc(ea) electrode selectively detected eserine with LOD value of 6.43×10−7 mol dm−3 and GCE/TiOPc(ea) electrode detected parathion with LOD value of 8.64×10−7 mol dm−3. All GCE/MPcs(ea) electrodes showed high sensitivity and wide linear ranges for those pesticides. These sensing data illustrated the usability of these modified electrodes in real samples such as seawater with good selectivity and sensitivity.
Antileishmanial Drug Miltefosine‐dsDNA Interaction in situ Evaluation with a DNA‐Electrochemical Biosensor
Authors: Machini W. B. S. , Oliveira‐Brett A. M. 
Published: November 2017

AbstractLeishmaniasis is one of the most important parasitic neglected disease. The electrochemical evaluation of the antileishmanial drug miltefosine‐dsDNA interaction was investigated in incubated solutions and using dsDNA‐electrochemical biosensors, following the changes in the oxidation peaks of guanosine and adenosine residues, and the occurrence of the free guanine residues, electrochemical signal. The electrochemical behaviour of miltefosine was also investigated, at a glassy carbon electrode, using cyclic, differential pulse and square wave voltammetry and no electrochemical redox processes were observed. The interaction mechanism of miltefosine‐dsDNA occurs in two ways: independent of the dsDNA sequence, and leading to the condensation/aggregation of DNA strands, producing a rigid miltefosine‐dsDNA complex structure, and a preferential interaction between the guanine hydrogen atoms in the C−G base pair and miltefosine, causing the release of guanine residues detected on the electrode surface. Miltefosine did not induce oxidative damage to DNA in the experimental conditions used.
Predicting the geomorphological responses of gravel‐bed rivers to flow and sediment source perturbations at the watershed scale: an application in an Alpine watershed
Authors: Alcayaga Hernán A. , Mao Luca , Belleudy Philippe 
Published: November 2017

AbstractPredicting morphological channel changes using physically‐based models requires extended data for the description of the river channel and for hydrological and sedimentological inputs. At the watershed scale, these data are usually scarce, and such a refined modeling is typically difficult to build. A simpler modeling of the morphological impacts due to the changes in the principal drivers that control channel shape and dynamics is more adaptable. In this study we focused on the morphological responses of gravel‐bed rivers to flow and sediment source perturbation at watershed scale. The aim is to develop and test a tool capable of semi‐quantitatively predicting the morphological river response at the watershed scale due to a set of spatially distributed perturbations. The model considers flow regime (Q) and sediment supply (S) as the two main factors controlling the fluvial morphology in alluvial rivers. Two indicators have been proposed to evaluate the alteration on Q and S, and they are illustrated as vectors on each reach of the river network. The magnitude of the vectors corresponds to the intensity of the perturbation and its direction represents the changing trend that nine selected morphological variables (bed elevation, slope, width, depth, wetted area, width to depth ratio, d50, terrace formation, and colonization of vegetation) are likely to follow from an initial state. The trends or trajectories of changes were assessed based on empirical relations, case studies, and conceptual models. This method was applied to the Isère watershed (5700 km2) at Grenoble (France), a river that hosts large and complex hydropower plant systems constructed during 50s ‐70s. The predictions over 23 river reaches and eight variables were evaluated in the range where the model was capable of predicting the morphological evolution of the river system. Its performance was verified and in the majority of the cases the results were coherent with field surveys and previous observations. The results indicate that this is a complex problem which needs more careful consideration of constraints that are difficult to assess, such as simultaneous and different sources of perturbations, hypotheses of initial dynamic equilibrium, and sediment supply quantification. Copyright © 2017 John Wiley & Sons, Ltd.
Multifluid flows with weak and strong discontinuous interfaces using an elemental enriched space
Authors: Idelsohn Sergio R. , Gimenez Juan M. , Nigro Norberto M. 
Published: November 2017

SummaryIn a previous paper, the authors presented an elemental enriched space to be used in a finite‐element framework (EFEM) capable of reproducing kinks and jumps in an unknown function using a fixed mesh in which the jumps and kinks do not coincide with the interelement boundaries. In this previous publication, only scalar transport problems were solved (thermal problems). In the present work, these ideas are generalized to vectorial unknowns, in particular, the incompressible Navier‐Stokes equations for multifluid flows presenting internal moving interfaces. The advantage of the EFEM compared with global enrichment is the significant reduction in computing time when the internal interface is moving. In the EFEM, the matrix to be solved at each time step has not only the same amount of degrees of freedom (DOFs) but also the same connectivity between the DOFs. This frozen matrix graph enormously improves the efficiency of the solver. Another characteristic of the elemental enriched space presented here is that it allows a linear variation of the jump, thus improving the convergence rate, compared with other enriched spaces that have a constant variation of the jump. Furthermore, the implementation in any existing finite‐element code is extremely easy with the version presented here because the new shape functions are based on the usual finite‐element method shape functions for triangles or tetrahedrals, and once the internal DOFs are statically condensed, the resulting elements have exactly the same number of unknowns as the nonenriched finite elements.
Perinatal maternal depressive symptoms alter amygdala functional connectivity in girls
Authors: Soe Ni Ni , Wen Daniel J. , Poh Joann S. , Chong Yap‐Seng , Broekman Birit Fp , Chen Helen , Shek Lynette P. , Tan Kok Hian , Gluckman Peter D. , Fortier Marielle V. , Meaney Michael J. , Qiu Anqi 
Published: November 2017

AbstractPerinatal maternal depressive symptoms influence brain development of offspring. Such effects are particularly notable in the amygdala, a key structure involved in emotional processes. This study investigated whether the functional organization of the amygdala varies as a function of pre‐ and postnatal maternal depressive symptoms. The amygdala functional network was assessed using resting‐state functional magnetic resonance imaging (rs‐fMRI) in 128 children at age of 4.4 to 4.8 years. Maternal depressive symptoms were obtained at 26 weeks of gestation, 3 months, 1, 2, 3, and 4.5 years after delivery. Linear regression was used to examine associations between maternal depressive symptoms and the amygdala functional network. Prenatal maternal depressive symptoms were significantly associated with the functional connectivity between the amygdala and the cortico‐striatal circuitry, especially the orbitofrontal cortex (OFC), insula, subgenual anterior cingulate (ACC), temporal pole, and striatum. Interestingly, greater pre‐ than post‐natal depressive symptoms were associated with lower functional connectivity of the left amygdala with the bilateral subgenual ACC and left caudate and with lower functional connectivity of the right amygdala with the left OFC, insula, and temporal pole. These findings were only observed in girls but not in boys. Early exposure to maternal depressive symptoms influenced the functional organization of the cortico‐striato‐amygdala circuitry, which is intrinsic to emotional perception and regulation in girls. This suggests its roles in the transgenerational transmission of vulnerability for socio‐emotional problems and depression. Moreover, this study underscored the importance of gender‐dependent developmental pathways in defining the neural circuitry that underlies the risk for depression.
A multimethod approach to inform epikarst drip discharge modelling: Implications for palaeo‐climate reconstruction
Authors: Campbell Micheline , Callow John Nikolaus , McGrath Gavan , McGowan Hamish 
Published: November 2017

AbstractResolving the hydrological processes that form speleothems and the palaeo‐climate archives that they contain is difficult. Typical approaches to hydrological investigation are not suited to karst landscapes, geophysics are seldom applied, drip monitoring and modelling have limitations, and ignoring potential hydrological impacts can result in a proxy record that does not reflect the external environment. We aim to understand the processes and controls that have created a palaeo‐climate proxy record preserved in a speleothem (JC001) in the “Grotto of Oddities,” part of the Jersey Cave at the Yarrangobilly Caves, Australia, to infer the likely nature and resolution of this record. Electrical resistivity tomography (ERT), traditional surveying, and drip discharge monitoring (April 2013 to February 2015) were used to investigate the structure and hydrology of the epikarst overlying the Grotto of Oddities. Data collected through these methods were then used to construct a physically informed and parsimonious drip hydrology model. Geophysics showed that changes in hillslope above the Grotto of Oddities are collocated with a region of low resistivity, which forms an epikarstic reservoir acting to supply enhanced discharge to the speleothem. Drip monitoring showed hysteretic behaviour with a distinct threshold response, and a simple drip classification indicated that the speleothem associated with the drip has the potential to record palaeo‐seasonality or an annual–decadal signal. Discharge modelling indicated discharge was comprised of quick and slow flow, and that discharge is probably perennial. These multimethod results together indicate that the speleothem likely represents a palaeo‐climate record of a length and resolution unprecedented for nonglacial areas of the Southern Hemisphere and for Australia in particular and will significantly enhance current knowledge of the climate of southeast Australia. Although ERT methods have previously been applied in the karst landscape, to our knowledge, this represents the first application of these multiple methods in combination as an approach to assess the fidelity of a speleothem, based on an understanding of the hydrological processes for palaeo‐climate reconstruction.
A comparison of nanoparticulate CpG immunotherapy with and without allergens in spontaneously equine asthma‐affected horses, an animal model
Authors: Klier John , Geis Sabine , Steuer Jeanette , Geh Katharina , Reese Sven , Fuchs Sebastian , Mueller Ralf S. , Winter Gerhard , Gehlen Heidrun 
Published: November 2017

AbstractIntroductionNew therapeutic strategies to modulate the immune response of human and equine allergic asthma are still under extensive investigation. Immunomodulating agents stimulating T‐regulatory cells offer new treatment options beyond conventional symptomatic treatment or specific immunotherapy for human and equine allergic airway diseases, with the goal of a homoeostatic T‐helper cell balance. The aim of this study was to evaluate the effects of a nebulized gelatin nanoparticle‐CpG formulation (CpG‐GNP) with and without specific allergens for the treatment of spontaneous allergic equine asthma as a model for human asthma.MethodsTwenty equine asthma‐affected horses were treated either with CpG‐GNP alone or CpG‐GNP with allergens. Two specific allergens were selected for each horse based on history and an in‐vitro test. Each horse received seven administrations of the respective nebulized composition and was examined before treatment, immediately after and 6 weeks after the treatment course.ResultsClinical parameters such as breathing rate, indirect interpleural measurement, arterial blood gases, amount of tracheal mucus and percentage of neutrophils and cytokines in tracheal washes and serum samples were evaluated. Treatment with CpG‐GNP alone as well as in combinations with relevant allergens resulted in clinical improvement of nasal discharge, breathing rate, amount of secretion and viscosity, neutrophil percentage and partial oxygen pressure directly after and 6 weeks after treatment. There were no significant differences between the two treatments in clinical parameters or local cytokine profiles in the tracheal wash fluid (IL‐10, IFN‐g, and IL‐17). IL‐4 concentrations decreased significantly in both groups.ConclusionNonspecific CpG‐GNP‐based immunotherapy shows potential as a treatment for equine and possibly also human allergic asthma.
Mechanisms of the action of adenine on anti‐allergic effects in mast cells
Authors: Hosoi Toru , Ino Shinsuke , Ohnishi Fumie , Todoroki Kenichi , Yoshii Michiko , Kakimoto Mai , Müller Christa E. , Ozawa Koichiro 
Published: November 2017

AbstractIntroductionMast cells play an important role in allergic responses.MethodsWe herein demonstrated the mechanisms of inhibitory effect of adenine on IgE/antigen‐induced degranulation and TNF‐α release in mast cells.ResultsWe found that these effects were dependent on the amino group of adenine because purine only weakly inhibited degranulation. Adenine also inhibited Ca2+ ionophore‐ and thapsigargin‐induced degranulation, however, this inhibitory effect was weaker than that of the antigen. Therefore, the inhibitory effects of adenine on degranulation may be mediated before as well as after the Ca2+ raise under the antigen stimulus. Adenine inhibited antigen‐induced Syk and the subsequent induction of AKT and ERK activation under FcϵRI‐mediated signal. Adenine also attenuated antigen‐induced increase in Ca2+. Furthermore, adenine inhibited IgE/antigen‐induced IKKα/β activation, which is involved in degranulation. Finally, adenine protected mice against anaphylactic allergic responses in vivo.ConclusionsThe present study revealed a key role of adenine in the attenuation of allergic responses through the inhibition of Syk‐mediated signal transduction and IKK‐mediated degranulation.
Selective C−H Functionalizations by Electrochemical Reactions with Palladium Catalysts
Authors: Kakiuchi Fumitoshi , Kochi Takuya 
Published: November 2017

AbstractEfficient, selective, transition‐metal‐catalyzed C−H functionalizations have been widely studied and are recognized as atom‐ and step‐economical tools in organic synthesis. During the past two decades, a variety of catalytic reactions involving C−H bond cleavage have been developed. In this review, we briefly survey studies dealing with transition‐metal‐catalyzed efficient and selective C−H functionalization by electrochemical reactions.
Meta‐analysis of associations between maternal breast cancer and the risk of adverse delivery outcomes
Authors: Sun Chenyu , Ding Xiuxiu , Wu Yile , Yang Liqi 
Published: November 2017

AbstractBackgroundResearch into the effects of breast cancer on delivery outcomes has generated inconsistent findings.ObjectivesTo pool data from existing observational studies of the effect of breast cancer on preterm delivery and low delivery weight.Search strategyA systematic literature search of PubMed, Embase, and Web of Science databases using keywords including, “breast cancer” and “birth outcome” up to March 7, 2017, was performed.Selection criteriaObservational studies of the effect of breast cancer on delivery outcomes were included.Data collection and analysisArticles were reviewed independently by two authors and data were extracted. Risk ratios and 95% confidence intervals were calculated.Main resultsPreterm delivery data were included from seven studies including 6 687 579 patients and low delivery weight data were retrieved from five studies including 6 687 103 patients. Maternal breast cancer was associated with an increased risk of preterm delivery (pooled risk ratio 1.82, 95% confidence interval 1.44–2.30) and low delivery weight (pooled risk ratio 1.41, 95% confidence interval 1.15–1.74). No publication bias was detected in the meta‐analysis.ConclusionsThe present meta‐analysis demonstrated that maternal breast cancer was associated with increased risk of preterm delivery and low delivery weight.
The prognostic value of perioperative, pre‐systemic therapy CA125 levels in patients with high‐grade serous ovarian cancer
Authors: May Taymaa , Stewart Jocelyn M. , Bernardini Marcus Q. , Ferguson Sarah E. , Laframboise Stephane , Jiang Haiyan , Rosen Barry 
Published: November 2017

AbstractObjectiveTo investigate the ability of preoperative CA125 and post‐surgical CA125 changes to predict outcomes among patients with high‐grade serous ovarian cancer (HGSC).MethodsThe present retrospective cohort study included patients with HGSC who underwent surgery between January 1, 2003, and December 31, 2011 at Princess Margaret Cancer Center, Toronto, ON, Canada. CA125 was measured at diagnosis and following surgery, and the CA125 ratio was calculated (preoperative CA125/postoperative CA125). Optimal CA125 cutoff levels were identified using the point with the most significant log‐rank‐test result. Univariate and multivariate analyses with Cox proportional hazard modeling was used to study overall survival.ResultsAmong 212 patients, an optimal baseline CA125 cutoff value of 174 U/mL and a seven‐fold decrease in CA125 after surgery were positive prognostic indicators. A 10‐fold increase in baseline CA125 was associated with decreased overall survival (univariate hazard ratio 1.55, 95% confidence interval [CI] 1.17–2.06; P=0.002; multivariate hazard ratio 1.72, 95% CI 1.21–2.44; P=0.002). An increase in the CA125 ratio (log10[preoperative CA125/postoperative CA125]) was associated with improved overall survival (univariate hazard ratio 0.63, 95% CI 0.43–0.90; P=0.012; multivariate hazard ratio 0.41, 95% CI 0.24–0.70, P<0.001).ConclusionCA125 demonstrated prognostic value for HGSC; baseline CA125 of 174 U/mL or lower and a post‐surgical decline of seven‐fold or greater were associated with improved overall survival.
A Queer Critical Media Literacies Framework in a Digital Age
Authors: van Leent Lisa , Mills Kathy 
Published: November 2017

AbstractMedia literacy skills are focal for many educators across the globe in an age of ubiquitous access to the Internet and the rapid circulation of digital texts. A critical media literacies perspective is often a key element in teaching adolescents to read a range of texts. A queer critical media literacies pedagogy supports a social justice agenda aimed at addressing inequalities in education for youths who identify as lesbian, gay, bisexual, transsexual, and queer (LGBTQ+), with the + accounting for other identities, such as asexual, agender, and questioning. Queer theories provide the basis of a new pedagogical model aimed at empowering educators to guide young adolescents in identity formation as they navigate a range of content. The model is presented as a queer critical media literacies framework aimed at directly supporting the work of teachers in classrooms, including illustrative key questions, learning experiences, and related teaching resources.
Transcriptional profiling reveals gene expression changes associated with inflammation and cell proliferation following short‐term inhalation exposure to copper oxide nanoparticles
Authors: Costa Pedro M. , Gosens Ilse , Williams Andrew , Farcal Lucian , Pantano Daniele , Brown David M. , Stone Vicki , Cassee Flemming R. , Halappanavar Sabina , Fadeel Bengt 
Published: November 2017

AbstractOur recent studies revealed a dose‐dependent proinflammatory response to copper oxide nanoparticles (CuO NPs) in rats following short‐term inhalation exposure for five consecutive days. Here transcriptomics approaches were applied using the same model to assess global gene expression in lung tissues obtained 1 day post‐exposure and after a recovery period of 22 days from rats exposed to clean air or 6 hour equivalent doses of 3.3 mg m−3 (low dose) and 13.2 mg m−3 (high dose). Microarray analyses yielded about 1000 differentially expressed genes in the high‐dose group and 200 in low‐dose compared to the clean air control group, and less than 20 after the recovery period. Pathway analysis indicated cell proliferation/survival and inflammation as the main processes triggered by exposure to CuO NPs. We did not find significant perturbations of pathways related to oxidative stress. Upregulation of epithelial cell transforming protein 2 (Ect2), a known oncogene, was noted and ECT2 protein was upregulated in the lungs of exposed animals. Proliferation of alveolar epithelial cells was demonstrated based on Ki67 expression. The gene encoding monocyte chemoattractant protein 1 (or CCL2) was also upregulated and this was confirmed by immunohistochemistry. However, no aberrant DNA methylation of inflammation‐associated genes was observed. In conclusion, we have found that inhalation of CuO NPs in rats causes upregulation of the oncoprotein ECT2 and the chemokine CCL2 and other proinflammatory markers as well as proliferation in bronchoalveolar epithelium after a short‐term inhalation exposure. Thus, pathways known to be associated with neoplastic processes and inflammation were affected in this model.