bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial effect of silver nanoparticles against Bacillus sp. under plasmon resonance condition
Authors: Lozovski Valeri , Rybalchenko Nataliya , Petrik Iryna , Kryvokhyzha Kostiantyn , Vasiljev Anatoliy , Vasyliev Taras 
Published: October 2024

Abstract

The interaction between the silver nanoparticles colloidal solutions and bacteria Bacillus sp. under plasmon resonance conditions is studied in the present work. The resonance conditions are realized by irradiating the bacteria/nanoparticles suspension with external light of resonant wavelength. Three types of nanoparticles are used - nanoparticles obtained with the method of chemical reduction (type I), thermal recovery method (type II), and photoreduction method (type III). For all three types of colloids, the antibacterial effect is not revealed in the case of simple mixing of the nanoparticle colloid with the bacteria solution. The antibacterial effect appears under irradiation by the light of resonance wavelength. In particular, the effect of external irradiation of resonant wavelength leads to a decrease in the infection activity of bacteria by 15–25% for all types of nanoparticles. The antibacterial effect is due to the action of ponderomotive forces on the bacterium membrane after the adsorption of the nanoparticle on it. The strength of the antibacterial effect depends on the thickness of the quercetin shell of the silver nanoparticle. In the case of a thick quercetin shell, the local field is smaller. Therefore, ponderomotive forces acting on the bacterial membrane are smaller.
Basement structural control in urban fracturing, a case study in Zacatecas, Mexico
Authors: Escalona-Alcázar Felipe de Jesús , García-Paniagua Estefanía , Pineda-Martínez Luis Felipe , Rodríguez-González Baudelio , Reveles-Flores Sayde María Teresa , Valle-Rodríguez Santiago 
Published: October 2024

Abstract

In this groundbreaking research we present a novel methodology for systematic fracture measurement in streets, sidewalks and walls. This approach, which incorporates both urban fracture data and geologic fault data, is a significant step forward in our understanding of the relationship between urban fractures and geologic faults. By calculating the paleostress axis, we were able to determine if fractures follow the urban area street array or if geologic faults control fracturing, leading to parallel data. The result reveals reverse faults dispersed in the NW and SE quadrants, while the normal faults have a clear tendency towards the NW and, to a lesser extent, to the NE, with the extension axis directed to the NE-SW. The orientation of the normal faults is parallel to that observed in the fractures in sidewalks, streets, and walls, as well as to the distribution of slopes and to that of the basement deformation. Moreover, the main drainage is also directed towards the WNW-ESE, it is, fault controlled. The parallelism between the urban fracturing and basement deformation suggests a close relationship between them, despite the construction process or materials quality.
Effect of Autism on Overweight in Children from a Socio-ecological Perspective
Authors: Kim Taeeung , Kwon Eun Hye 
Published: October 2024

Abstract

Background Although autism spectrum disorder (ASD) is known to be correlated with chronic physical conditions such as gastrointestinal disorders, musculoskeletal problems, and sensory processing disorders, a nationwide nonclinical sample of overweight children with ASD is limited. We aimed to use a large nationally representative non-clinical sample to explore the relationship between ASD and childhood adjusted for socio-ecological factors.Methods This cross-sectional data analysis from the 2021 National Survey of Children’s Health was conducted with the modified ecological systems theory model as the guiding framework. A propensity-score matching analysis helped isolate the factors affecting the weight status (i.e., being overweight) in children with ASD, controlling for demographic characteristics, physical activity habits, and familial and environmental circumstances.Results Among the 20,091 individuals (mean age, 13.77 years; girls, 48.59%; equivalent to 32,211,963 individuals in the general population) identified for this study, 1,348 individuals (mean age, 13.94 years; girls, 22.55%; representing 1,904,381 individuals from the general population) were examined in our final matched model to determine the link between ASD and being overweight in children. ASD had a statistically significant effect on being overweight. Notably, children with ASD and those with similar socio-ecological factors showed a higher risk of being overweight if they were Hispanic, had less healthy parents, or were involved in more structured activities (all p-values < .05).Conclusions Our findings underscore a pronounced association between autistic children and being overweight. This underscores the necessity for careful attention towards preventing excessive weight gain and for tailored management in children who experience the neuropsychological difficulties associated with ASD.
Development of Predictive Models for Pathological Response Status in Breast Cancer after Neoadjuvant Therapy Based on Peripheral Blood Inflammatory Indexes
Authors: Liu Shuqiang , Jiang Cong , Wu Danping , Zhang Shiyuan , Qiao Kun , Yang Xiaotian , Yu Boqian , Huang Yuanxi 
Published: October 2024

Abstract

Background.
Achieving a pathological complete response (pCR) after neoadjuvant therapy (NAT) is considered to be a critical factor for a favourable prognosis in breast cancer. However, discordant pathological complete response (DpCR), characterised by isolated responses in the breast or axillary, represents an intermediate pathological response category between no response and complete response. This study aims to investigate predictive factors and develop models based on peripheral blood inflammatory indexes to more accurately predict NAT outcomes.
Method.
A total of 789 eligible patients were enrolled in this retrospective study. The patients were randomized into training and validation cohort according to a 7:3 ratio. Lasso and uni/multivariate logistic regression analysis were applied to identify the predictor variables. Two Nomograms combining clinico-pathologic features and peripheral blood inflammatory indexes were developed.
Result.
Molecular Subtype, HALP, P53, and FAR were used to construct the predictive models for traditional non-pCR (T-NpCR) and total-pCR (TpCR). The T-NpCR group was divided into DpCR and non-pCR (NpCR) subgroups to construct a new model to more accurately predict NAT outcomes. cN, HALP, FAR, Molecular Subtype, and RMC were used to construct the predictive models for NpCR and DpCR. The receiver operating characteristic (ROC) curves indicate that the model exhibits robust predictive capacity. Clinical Impact Curves (CIC) and Decision Curve Analysis (DCA) indicate that the models present a superior clinical utility.
Conclusion.
HALP and FAR were identified as peripheral blood inflammatory index predictors for accurately predicting NAT outcomes.
Analyzing Trends in Socioeconomic Disparities in Oral Health Services: A concentration index decomposition approach (2005- 2021)
Authors: Liu Jie , Huang Xiangyu , Fan Weihua , Liu Zhi’e , Huang Shaohong , Qin Yuandong 
Published: October 2024

Abstract

Background
This study aims to (a) examine trends in socioeconomic-related inequalities in the utilization of oral health services among adults in Guangdong Province from 2005 to 2021, and (b) decompose these trends to identify the underlying factors influencing these inequalities.
Methods
Three cross-sectional studies were conducted among adults aged 35–44 and 65–74 in Guangdong Province during 2005–2006 (OHES I), 2015–2016 (OHES II), and 2021–2022 (OHES III). Participants underwent oral health examinations and completed questionnaires about their oral health. The study employed concentration curves and the Erreygers-corrected concentration index (EI) to measure trends in socioeconomic-related inequality in the utilization of oral health services. Additionally, the horizontal inequity index (HI) was calculated to assess the degree of inequity in oral health care utilization after accounting for need factors (self-rated oral health, DMFT, and number of teeth). Decomposition analyses were conducted to evaluate the contributions of income level, need factors, and other variables (age, gender, education, and medical insurance coverage) to overall inequality in dental care utilization.
Results
The findings reveal a growing trend of inequality in dental care utilization, with a marked concentration among wealthier individuals. Decomposition analysis highlighted that household income, education level, and medical insurance coverage are significant contributors to this inequality. Specifically, higher income and educational attainment exacerbated disparities, while the current medical insurance systems were insufficient in mitigating these gaps. Universal basic education was found to promote more equitable access to dental care, but overall, medical insurance did not effectively address the inequality.
Conclusions
The study underscores an increasing concentration of dental care utilization among higher-income groups and identifies critical areas for healthcare reform. Enhancing subsidies for lower-income individuals and improving medical insurance coverage are essential steps to reduce socioeconomic disparities in dental care access. These findings provide valuable insights for policymakers aiming to achieve greater equity in oral health services.
Midkine promotes tumor growth and attenuates the effect of cisplatin in small cell lung cancer
Authors: Ito Shotaro , Sakakibara-Konishi Jun , Sato Mineyoshi , Shoji Tetsuaki , Furuta Megumi , Takahashi Hirofumi , Tsuji Kosuke , Morinaga Daisuke , Kashima Masahiro , Kitai Hidenori , Kikuchi Junko , Kikuchi Eiki , Hatanaka Kanako C , Hatanaka Yutaka , Hida Kyoko , Noguchi Takuro , Konno Satoshi 
Published: October 2024

Abstract

Purpose
Small cell lung cancer (SCLC) is a highly aggressive disease with poor survival. Nevertheless, the addition of an anti-programmed death ligand 1 antibody to platinum combination chemotherapy can improve its prognosis. However, only a few patients achieve a long-term response; thus, establishing new therapies for SCLC is crucial. Midkine (MDK) is a heparin-binding growth factor that plays a role in various biological processes such as cell proliferation and chemotherapy resistance in diverse cancers. MDK has garnered attention as a therapeutic and diagnostic target for several cancers; however, studies evaluating its expression and function in SCLC are scarce.
Methods
The MDK expression was analyzed in vitro and in vivo by ELISA, immunohistochemistry, western blotting. The effect of MDK on cell proliferation and the effect of cisplatin was evaluated by MTT assay.
Results
MDK was expressed pathologically in human SCLC tumor tissues but not in normal lung tissues. Human serum MDK concentration in patients with SCLC reflected the SCLC tumor burden and was correlated to the response to treatment. Moreover, MDK induced cell proliferation and attenuated the effect of cisplatin in SCLC cell lines. The combination of an MDK inhibitor and cisplatin exerted synergistic antitumor effects both in vitro and in vivo. Additionally, MDK positively regulated the AKT pathway.
Conclusion
The present results indicate that MDK contributes to cell proliferation and chemotherapy resistance by activating the AKT pathway in SCLC. Therefore, MDK may be a potential therapeutic and diagnostic target for SCLC.
Collagen turnover biomarkers to predict outcome of patients with biliary cancer
Authors: Kaps Leonard , Genc Muhammed A. , Moehler Markus , Grabbe Stephan , Schattenberg Jörn M. , Schuppan Detlef , Pedersen Rasmus Sund , Karsdal Morten A. , Mildenberger Philipp , Maderer Annett , Willumsen Nicholas 
Published: October 2024

Abstract

Background
The collagen-rich tumor stroma plays a crucial role in biliary tract cancer (BTC). Circulating collagen turnover markers of type I collagen (reC1M), type III collagen (PRO-C3), type IV collagen (C4G), type VIII collagen (PRO-C8), type XI collagen (PRO-C11), type XVII collagen (PRO-C17) and type VIII collage (TUM) may be used as potential non-invasive biomarkers.
Methods
We measured the seven biomarkers of collagen turnover in sera of 72 patients with BTC at baseline and after first and second chemotherapy cycle (CTX). Markers were also assessed in sera of 50 healthy donors and compared to levels of patients at baseline. The diagnostic and prognostic value of the markers was evaluated for overall survival (OS) and progression-free survival (PFS).
Results
Except C4G, all collagen turnover markers were significantly (p < 0.001) increased in serum from patients with BTC compared to healthy controls. PRO-C3 was the best marker to discriminate between patients with BTC and controls, reaching an AUROC of 0.98 (95% CI 0.95; 0.99) with a sensitivity (92%) and specificity (94%) balanced cutoff of 77.3 ng/ml. Patients with high levels (cohort separated by median split) of PRO-C8 (HR 2.85, 95% CI 1.42; 5.73) followed by C3M (HR 2.33, 95% CI 1.2; 4.5), PRO-C3 (HR 3.09, 95% CI 1.5; 6.36) and CA 19 − 9 (HR 2.52, 95% CI 1.37; 4.64) as reference biomarker had a shorter OS. Notably, only the novel marker PRO-C8 was also predictive of PFS (HR 3.26, 95% CI 1.53; 6.95). Associations with survival outcomes remained significant after adjusting for relevant risk factors (CA 19 − 9 and CEA at baseline, age, presence of metastases, weight, height and gender).
Conclusion
The collagen turnover markers PRO-C8, C3M, PRO-C3 and the established biomarker CA 19 − 9 were prognostic for OS in patients with BTC while only PRO-C8 was also predictive for PFS. PRO-C3 showed the best diagnostic performance to discriminate between patients with BTC and controls.
Dynamic changes in maternal cardiac function in pregnancy
Authors: Wang Xiu-Juan , Chen Ling-Ling , Kong Ling-Yun , Xiang Wei , Fu Li , Li Xiao-Wei , Hong Ming-Huan , Liu Fang 
Published: October 2024

Abstract

Background
Pregnant women experience a number of physiologic changes that, if uncompensated, may result in varied degrees of cardiac function impairment. Left ventricular (LV) global longitudinal strain (GLS) and P-wave to A’ duration on tissue Doppler imaging (PA-TDI) are more sensitive and can identify changes in cardiac function early on.
Methods
The study was a cross-sectional study. A total of 165 healthy pregnant women were enrolled in this study, including 48 women in early pregnancy (before 13 weeks' gestation), 37 in mid-pregnancy (14–27 weeks’ gestation), 80 in late pregnancy (after 28 weeks' gestation), while 142 age, height, and weight matched healthy nonpregnant women were included. The clinical data and echocardiographic parameters concerning left atrial and left ventricular function were assessed.
Results
PA-TDI was prolonged in late pregnancy [121.11 (113.03-129.18)] compared to the first trimester [117.65 (107.27-121.11); P = 0.041] and the second trimester of pregnancy [114.19 (105.54-117.65); P = 0.043]. The inclusion of week of gestation, heart rate, pre-pregnancy body mass index (BMI), and hemoglobin to construct a multifactorial regression equation showed a significant difference in the effect of week of gestation on PA-TDI (b = 0.391, t = 3.960, P < 0.001). Left ventricular ejection fraction was lower in late gestation than in early gestation. The absolute value of LV-GLS gradually decreased with increasing gestational weeks (early gestation: 19.49% ± 3.69%; mid-gestation: 18.15% ± 4.00%; late gestation: 15.23% ± 3.87%; P < 0.001). The multifactor regression analysis revealed a significant difference in the influence of gestational week on LV-GLS (b = 0.149, t = 5.618, P < 0.001). LV mass (LVM) was higher in late pregnancy. Additionally, mitral valve E peak, E/A, and e' were lower than in early pregnancy. E/e' was not statistically different in early, middle and late pregnancy.
Conclusion
Healthy pregnant women showed a trend of reduced left atrial function, left ventricular systolic function and diastolic function, but not to the extent of left heart dysfunction. Moreover, PA-TDI and LV-GLS can be used to evaluate early changes in left cardiac function in pregnant women, and PA-TDI measurements are simple, convenient, accurate and reproducible.
The impact of forced internal displacement on cognitive and executive skills in Colombian adolescents: protocol for an observational case-control study
Authors: Valencia Angélica , García-Sánchez Efraín , Vernaza María Alejandra , Bejarano-Valencia Yamileth , Jiménez-Polania Amparo , Provasi Joëlle 
Published: October 2024

Abstract

BackgroundInternal displacement, where individuals are forced to flee their homes but remain within their country of origin, is a significant issue in conflict-affected countries like Colombia. Internally displaced (ID) adolescents experience disrupted living conditions, ongoing conflict exposure, and elevated rates of post-traumatic stress disorders (PTSD). Despite the impact of these factors on neurocognitive development, this area remains underexplored in ID adolescents. This study aims to evaluate the cognitive ability and executive functioning of Colombian ID adolescents compared to non-ID adolescents, and also examine how household income, parental education levels, and area of residence moderate the association between ID status and these skills.MethodThis observational case-control study will recruit two groups of adolescents (aged 12 to 16) from six high schools in a Colombian municipality affected by armed conflict. ID adolescents (n = 130) and non-ID adolescents (n = 130) will complete the Wechsler Intelligence Scale for Children-V (WISC-V) to assess cognitive ability and the 'Batería Neuropsicológica de Funciones Ejecutivas y Lóbulos Frontales-3' (BANFE-3) to assess executive functioning. Socioeconomic data will be collected from the municipal school database and a self-administered parental questionnaire. Regression analysis will be used to address the study objectives.DiscussionThis study will address the critical need for data on the impact of internal displacement on the cognitive and executive skills of ID adolescents. The findings will inform targeted interventions to mitigate the potential risk of cognitive impairments in these adolescents, thereby promoting their well-being, as encouraged and emphasized by international guidelines. Although this study will focus on Colombian ID adolescents, our results could benefit a broader panel of victims of internal displacement, the number of which has doubled globally in the last decade.Trial registrationThe study is preregistered on the Open Science Framework.
Polyploid cancer cells reveal signatures of chemotherapy resistance
Authors: Hicks James , Schmidt Michael , Nahgdloo Amin , Prabakar Rishvanth , Kamal Mohamed , Cadaneanu Radu , Garraway Isla , Lewis Michael , Aparicio Ana , Zurita Amado , Corn Paul , Kuhn Peter , Pienta Kenneth , Amend Sarah 
Published: October 2024

Abstract

Therapeutic resistance in cancer significantly contributes to mortality, with many patients eventually experiencing recurrence after initial treatment responses. Recent studies have identified therapy-resistant large polyploid cancer cells in patient tissues, particularly in late-stage prostate cancer, linking them to advanced disease and relapse. Here, we analyzed bone marrow aspirates from 44 advanced prostate cancer patients and found the presence of CTC-IGC was significantly associated with poorer progression-free survival. Single cell copy number profiling of CTC-IGC displayed clonal origins with typical CTCs, suggesting complete polyploidization. Induced polyploid cancer cells from PC3 and MDA-MB-231 cell lines treated with docetaxel or cisplatin were examined through single cell DNA sequencing, RNA sequencing, and protein immunofluorescence. Novel RNA and protein markers, including HOMER1, TNFRSF9, and LRP1, were identified as linked to chemotherapy resistance. These markers were also present in a subset of patient CTCs and associated with recurrence in public gene expression data. This study highlights the prognostic significance of large polyploid tumor cells, their role in chemotherapy resistance, and their expression of markers tied to cancer relapse, offering new potential avenues for therapeutic development.
Investigating metabolic control and complications in type 2 diabetic patients with low income in northwest of Iran, 2023
Authors: Yarahmadi Shahin , Nikkhoo Bahram , Miraki Paria , Rahmani Khaled 
Published: October 2024

Abstract

Background and aim: Socioeconomic factors are very important in non-communicable diseases (NCD) and their complications as a risk factor or as a barrier to receive
effective health care. This study aimed to determine the prevalence of diabetes complications and factors related to glycemic control in type 2 diabetic patients with low income in Kurdistan Province, Iran.
Method: This cross-sectional study was conducted on 608 diabetic patients supported by the Imam Khomeini Relief Foundation in 2023 in the province of Kurdistan, northwest of Iran. In addition to collecting demographic data, major complications of diabetes were specified by clinical examination by specialist physicians and paraclinical data. Data analysis was performed in Stata version 16 using descriptive statistics and logistic regression modeling.
Results: A total of 608, 76.6% female, with mean age 62.7 years were investigated. Prevalence of retinopathy, nephropathy, neuropathy, and diabetic foot ulcers were 42.9%, 6.9%, 3.3% and 4.3%, respectively. HbA1C levels were favorable (≤7.5) in only 231 (38.0%) patients. Longer duration of diabetes was associated with worse glycemic control, whereas comorbidity of DM and hypertension was significantly associated with good glycemic control.
Conclusion: Based on the results obtained, the health care and glycemic control status of low-income diabetic patients is not favorable. Considering the vulnerability of this group due to their low-risk perception and low income, it is recommended to teach self-care behaviors and plan routine care to prevent disease complications and, if necessary, fully cover the cost of care for these patients by the national health system.