bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality Related to Appendectomy; a Population Based Analysis over Two Decades in Finland
Authors: Kotaluoto Sannamari , Ukkonen Mika , Pauniaho Satu‐Liisa , Helminen Mika , Sand Juhani , Rantanen Tuomo 
Published: August 2016

AbstractObjectTo define the mortality rate of appendectomy patients and appendectomy‐related risk factors.BackgroundAppendectomy has been considered as a safe operation and negative appendectomies acceptable in order to avoid perforations. There are few publications on appendectomy‐related mortality. Removal of a normal appendix has been suggested to be related to a higher mortality rate versus removal of an inflamed appendix.MethodsData on all appendectomy patients between 1990 and 2010 in Finland were retrieved from the Discharge Register of the National Institute for Health and Welfare and combined with data from the Death Certificate Register of Statistics Finland. Thirty‐day mortality was identified and compared with overall mortality. Detailed information from death certificates of patients dying within 30‐day post‐surgery was collected and analyzed.ResultsOver the study period, the thirty‐day post‐appendectomy mortality rate was 2.1/1000. Increased mortality was found in patients over 60 years of age. Negative appendectomy and complicated appendicitis were related to mortality. The negative appendectomy rate was higher in patients older than 40 years of age. During the study period, both mortality and the rate of negative appendectomies decreased, while the rate of laparoscopic appendectomies increased.ConclusionsPost‐appendectomy mortality is related to both negative appendectomies and complicated appendicitis. Diagnostic accuracy is fundamental in the care of patients with acute appendicitis, especially in the elderly. Improved diagnostic accuracy may have reduced mortality over the last two decades in Finland.
Overexpressing target helper genes enhances secretion and glycosylation of recombinant proteins in Pichia pastoris under simulated microgravity
Authors: Huangfu Jie , Xu Yinghua , Li Chun , Li Jun 
Published: August 2016

Abstract
In this study, the potential helper genes were identified through the data analysis of transcriptomic and proteomic profiling in recombinant Pichia pastoris cultured under simulated microgravity (SMG). Co-expressing of four genes PRX1, YAP1, AHA1, and YPT6, involved in the oxidative stress response and protein folding, exhibited promising helper factor effects on the recombinant protein yields in engineered P. pastoris, respectively. When two of the above genes were co-expressed simultaneously, β-glucuronidase (PGUS) specific activity was further increased by 30.3–50.6 % comparing with that of single helper gene, particularly when the oxidative stress response and protein folding genes were both present in the combinations. In addition, co-expressing co-chaperone AHA1 and transcription factor YAP1 not only enhanced PGUS secretion, but also affected its glycosylation. Thus, through deep “omics” analysis of SMG effects, our results provided combined impact of new helper factors to improve the efficacy of recombinant protein secretion and glycosylation in engineered P. pastoris.
Composition and Structure of Single Cell Oil Produced by Schizochytrium limacinum SR31
Authors: Zhang Tao , Lou Fei , Tao Guanjun , Liu Ruijie , Chang Ming , Jin Qingzhe , Wang Xingguo 
Published: August 2016

AbstractSchizochytrium limacinum sp. was commercially utilized to produce single cell oil (SCO), but its detailed lipid profile remains unknown. In order to analyze the composition and structure of SCO produced by Schizochytrium limacinum SR31, the SCO extracted at stationary growth phase was separated into neutral lipids (NL), polar lipids and glycolipids by using silica gel column chromatography. The result of lipid classes in NL revealed that triacylglycerol (TAG) was the primary glyceride (93.81 %). Fatty acid (FA) analysis by gas chromatography–mass spectrometer (GC–MS) proved that palmitic acid (29.78 %) and docosahexaenoic acid (25.64 %) were the major FA. Quadrupole time of flight mass spectrometry in electrospray ionization mode coupled with ultra‐performance liquid chromatography was carried out to investigate TAG structures. More than 80 species were identified. Positional distribution of FA in TAG might contribute to further study of the FA shifts during the lipid turnover stage and nutritional evaluation of the SCO.
Compartment syndrome in infants and toddlers
Authors: Broom Alexander , Schur Mathew D. , Arkader Alexandre , Flynn John , Gornitzky Alex , Choi Paul D. 
Published: August 2016

Purpose To study the cause, diagnosis, treatment and outcome of acute compartment syndrome in infants and toddlers aged <3 years. Methods Fifteen patients aged <3 years with acute compartment syndrome were identified from two large pediatric trauma centers over a fifteen-year period. All children underwent fasciotomy. The mechanism of injury, time of injury, time to diagnosis, compartment pressures, time to fasciotomy, and outcome at the time of the latest follow-up were recorded. Results Nine (60 %) of fifteen patients developed compartment syndrome secondary to trauma, four (4/15, 27 %) due to infection, and two (2/15, 13 %) due to intravenous infiltration. The average time from injury or hospital admission to fasciotomy was 31.8 h (range 2.9–136.3 h). In general, the functional outcome was excellent at the latest follow-up with thirteen (13/15, 87 %) patients having an excellent outcome. No cases of Volkmann's ischemia were noted at the time of fasciotomy, even when performed as late as 5 days after injury. Conclusions Compared to the general pediatric population, the diagnosis of compartment syndrome in infants and toddlers may be further delayed, i.e., >24 h after injury. Despite delays in diagnosis and time to treatment, the present study shows that outcomes in infants and toddlers remain favorable even when fasciotomy is performed 48–72 h after injury. Level of evidence Case series, level IV.
Numerical investigation of the flow over a model transonic turbine blade tip
Authors: Wheeler Andrew P. S. , Sandberg Richard D. 
Published: August 2016

Direct numerical simulations (DNS) are used to investigate the unsteady flow over a model turbine blade tip at engine-scale Reynolds and Mach numbers. The DNS are performed with an in-house multiblock structured compressible Navier–Stokes solver. The particular case of a transonic tip flow is studied since previous work has suggested that compressibility has an important effect on the turbulent nature of the separation bubble at the inlet to the tip–casing gap and subsequent flow reattachment. The flow is simulated over an idealized tip geometry where the tip gap is represented by a constant-area channel with a sharp inlet corner to represent the pressure side edge of the turbine blade. The effects of free-stream disturbances, cross-flow and the pressure side boundary layer on the tip flow aerodynamics and heat transfer are studied. For ‘clean’ inflow cases we find that even at engine-scale Reynolds numbers the tip flow is intermittent in nature, i.e. neither laminar nor fully turbulent. The breakdown to turbulence occurs through the development of spanwise streaks with wavelengths of approximately 15 %–20 % of the gap height. Multidimensional linear stability analysis confirms the two-dimensional base state to be most unstable with respect to spanwise wavelengths of 25 % of the gap height. The linear stability analysis also shows that the addition of cross-flows with 25 % of the streamwise gap exit velocity increases the stability of the tip flow. This is confirmed by the DNS, which also show that the turbulence production is significantly reduced in the separation bubble. For the case when free-stream disturbances are added to the inlet flow, viscous dissipation and the rapid acceleration of the flow at the inlet to the tip–casing gap cause significant distortion of the vorticity field and reductions of turbulence intensity as the flow enters the tip gap. The DNS results also suggest that the assumption of the Reynolds analogy and a constant recovery factor are not accurate, in particular in regions where the skin friction approaches zero while significant temperature gradients remain, such as in the vicinity of flow reattachment.
Analysis of Residual Stresses on the Vibration of a Circular Sensor Diaphragm with Surface Effects
Authors: Zhou S.-S. , Zhou S.-J. , Li A.-Q. , Wang B.-L. 
Published: August 2016

AbstractResonant micro-biochemical sensors play important roles in a wide range of emerging applications to detect biochemical molecules. As the resonators of micro-biochemical sensors, the vibration characteristics of circular sensor diaphragms are important for the design of diaphragm-based resonant micro-biochemical sensors. In this paper, the influence of residual stresses on the vibration of a circular sensor diaphragm with surface effects is analyzed. Based on the Kirchhoff's plate theory and surface elasticity theory, the governing equation is presented. The material characteristic lengths for different surface effects are obtained. The influences of residual stresses on the effective flexural rigidity and natural frequency of the diaphragm with surface effects are discussed. Results show that the influence of residual stresses on the effective flexural rigidity becomes obvious with the increasing of residual stresses. The first order natural frequency increases rapidly when the tension parameter is larger than 30 for the stiffened surfaces, while for the softened surfaces the value is 10. Moreover, surface effects can influence the transition range of diaphragm from the plate behavior to membrane behavior in terms of the tension parameter. The transition range can be enlarged by the stiffened surface and be shortened by the softened surface. The analysis and results are helpful for the design of sensor diaphragm-based resonant micro-biochemical sensors and some related researches.
Effects of isovalerate supplementation on growth performance and ruminal fermentation in pre- and post-weaning dairy calves
Authors: LIU Q. , WANG C. , ZHANG Y. L. , PEI C. X. , ZHANG S. L. , WANG Y. X. , ZHANG Z. W. , YANG W. Z. , WANG H. , GUO G. , HUO W. J. 
Published: August 2016

SUMMARYThe objective of the present study was to evaluate the effects of isovalerate supplementation on growth performance and ruminal fermentation in pre- and post-weaning dairy calves. Forty-eight Chinese Holstein male calves at 15 days of age and 45·1 ± 0·36 kg body weight (BW) were assigned randomly to four groups. The treatments were: control, low-isovalerate, moderate-isovalerate (MIV) and high-isovalerate (HIV) with 0, 3, 6 and 9 g isovalerate per calf per day, respectively. Isovalerate was hand-mixed into milk in pre-weaning calves and the concentrate portion in post-weaning calves. The study lasted 75 days, including a 15-day adaptation period followed by a 60-day sampling period. Weaning was conducted when calves were 60 days old. Six calves were chosen from each treatment at random and slaughtered at 30 and 90 days of age. Average daily weight gain increased linearly whether during pre-weaning or post-weaning period with increasing isovalerate supplementation. Dry matter intake linearly increased at 90 days of age with increasing isovalerate supplementation. During weaning, ruminal pH and ammonia nitrogen (N) decreased linearly, whereas total ruminal volatile fatty acid concentration increased linearly with increasing isovalerate supplementation. The ratio of acetate to propionate increased linearly with increasing isovalerate supplementation due to increased acetate concentration and the unchanged propionate concentration. Activities of caboxymethyl-cellulase, cellobiase, xylanase and pectinase linearly increased at 90 days of age, α-amylase and β-amylase activities linearly increased at 30 and 90 days of age. Relative quantities of Butyrivibrio fibrisolvens, Ruminococcus albus, Fibrobacter succinogenes and Ruminococcus flavefaciens increased linearly with increasing isovalerate supplementation. Ruminal fermentation, enzyme activities and cellulolytic bacteria were higher for HIV and MIV than for the control. The present results indicate that isovalerate accelerated growth of calves by improving ruminal fermentation, microbial enzyme activities and cellulolytic bacteria growth during weaning. In the experimental conditions of the current trial, the optimum isovalerate dose was about 6·0 g isovalerate per calf per day.
Research on a multimodal actuator-oriented power-assisted knee exoskeleton
Authors: Han Yali , Zhu Songqing , Zhou Zhou , Shi Yu , Hao Dabin 
Published: August 2016

SUMMARYA multimodal actuator was proposed to achieve a more agile power-assisted exoskeleton in uncertain complex walking environments. A power-assisted knee exoskeleton prototype based on a multimodal actuator was constructed. With this multimodal actuator, several modes of operation in the power-assisted knee exoskeleton during a motion cycle are actuated, including series elastic actuation, stiff position control, and energy storage and release. Also, a control strategy for power-assisted knee exoskeleton motion control based on a state machine is developed. The ability of the power-assisted knee exoskeleton to follow human motion was tested, and the results showed that the angle error of the knee exoskeleton followed the human motion is not more than 0.4˚, and the response time error of the knee exoskeleton followed the human motion is not more than 0.2 s.
Current epidemiology of tetanus in England, 2001–2014
Authors: COLLINS S. , AMIRTHALINGAM G. , BEECHING N. J. , CHAND M. A. , GODBOLE G. , RAMSAY M. E. , FRY N. K. , WHITE J. M. 
Published: August 2016

SUMMARYPublic Health England conducts enhanced national surveillance of tetanus, a potentially life-threatening vaccine-preventable disease. A standardized questionnaire was used to ascertain clinical and demographic details of individuals reported with clinically suspected tetanus. The 96 cases identified between 2001 and 2014 were analysed. The average annual incidence was 0·13/million (95% confidence interval 0·10–0·16) of which 50·0% were male. Where reported, 70·3% of injuries occurred in the home/garden (45/64). Overall, 40·3% (31/77) cases were in people who inject drugs (PWID), including a cluster of 22 cases during 2003–2004. Where known (n = 68), only 8·8% were age-appropriately immunized. The overall case-fatality rate was 11·0% (9/82). All tetanus-associated deaths occurred in adults aged >45 years, none of whom were fully immunized. Due to the success of the childhood immunization programme, tetanus remains a rare disease in England with the majority of cases occurring in older unimmunized or partially immunized adults. Minor injuries in the home/garden were the most commonly reported likely sources of infection, although cases in PWID increased during this period. It is essential that high routine vaccine coverage is maintained and that susceptible individuals, particularly older adults, are protected through vaccination and are offered timely post-exposure management following a tetanus-prone wound.
Varicella-zoster immunoglobulin treatment in pregnant women in Denmark from 2005 to 2015: descriptive epidemiology and follow-up
Authors: JESPERSEN C. , HELMUTH I. G. , KRAUSE T. G. 
Published: August 2016

SUMMARYPrimary infection with varicella-zoster virus in pregnancy poses a risk of severe infection and embryopathies. Upon exposure, seronegative women are candidates for varicella-zoster immunoglobulin (VZIG). The aim of this paper was to describe risk factors for VZIG treatment including sources of varicella exposure and to study how many women developed clinical infection and received postpartum vaccination. We identified all pregnant women who received VZIG from December 2005 to March 2015. Additional information was obtained from Danish registers and a follow-up questionnaire. A total of 104 women were included and 88 completed the questionnaire. Significantly more women had ‘other country of origin’ than Denmark. They were more often second para (57%) and had most commonly been exposed to varicella by their own child (58%). Five women developed clinical varicella infection, and only 26·5% were vaccinated after delivery. The study concludes that few women developed infection after VZIG and none developed pneumonia. General practitioners should be particularly aware of obtaining varicella anamnesis in parous women from non-temperate countries in order to perform selective vaccination prior to pregnancy. In case of varicella exposure during pregnancy in a seronegative woman, postpartum vaccination is crucial.
Alcohol Consumption Does not Impede Recovery from Mild to Moderate Traumatic Brain Injury
Authors: Silverberg Noah D. , Panenka William , Iverson Grant L. , Brubacher Jeffrey R. , Shewchuk Jason R. , Heran Manraj K.S. , Oh Gary C.S. , Honer William G. , Lange Rael T. 
Published: August 2016

AbstractObjectives: To examine the effect of pre-injury alcohol use, acute alcohol intoxication, and post-injury alcohol use on outcome from mild to moderate traumatic brain injury (TBI). Methods: Prospective inception cohort of patients who presented to the Emergency Department with mild to moderate TBI and had a blood alcohol level (BAL) taken for clinical purposes. Those who completed the 1-year outcome assessment were eligible for this study (N=91). Outcomes of interest were the count of post-concussion symptoms (British Columbia Post-Concussion Symptom Inventory), low neuropsychological test scores (Neuropsychological Assessment Battery), and abnormal regions of interest on diffusion tensor imaging (low fractional anisotropy). The main predictors were pre-injury alcohol consumption (Cognitive Lifetime Drinking History interview), BAL, and post-injury alcohol use. Results: The alcohol use variables were moderately to strongly inter-correlated. None of the alcohol use variables (whether continuous or categorical) were related to 1-year TBI outcomes in generalized linear modeling. Participants in this cohort generally had a good clinical outcome, regardless of their pre-, peri-, and post-injury alcohol use. Conclusions: Alcohol may not significantly alter long-term outcome from mild to moderate TBI. (JINS, 2016, 22, 816–827)
Herschel/SPIRE colors of galaxies at z>2.5
Authors: Yuan F.-T. , Buat V. , Burgarella D. , Ciesla L. , Heinis S. , Shen S. , Shao Z.-Y. , Hou J. -L. 
Published: August 2016

AbstractWe compiled a sample of 57 galaxies with spectroscopically confirmed redshifts and SPIRE detections in all three bands at z = 2.5-6.4, and compared their SPIRE colors with SED templates from local and high-z libraries. We find that local calibrations are inconsistent with high-z observations. For high-z libraries, the templates with an evolution from z = 0 to 3 can describe the average colors of the observations at high redshift well. Based on the templates, we defined color cuts to divide the SPIRE color-color diagram into different regions with different mean redshifts. We tested this method and two other color cut methods using a larger sample (783 galaxies) with photometric redshifts. We find that these color cuts can separate the sample into subsamples with different mean redshifts, but the dispersion of redshifts in each subsample is considerably large. Additional information is needed for better sampling.
Life in Low Density Environments – Field Galaxies from z=1.0 to the Present
Authors: Jørgensen Inger , Fisher Scott , Woodrum Charity , Kwan Teiler , Bieker Jacob 
Published: August 2016

AbstractWe present results on the stellar populations of bulge-dominated field galaxies at redshifts up to ≈1.0. The sample consists of non-cluster galaxies observed as part of the spectroscopic observations for the Gemini/HST Galaxy Cluster Project (GCP). Our preliminary results show that the bulge-dominated field galaxies contain younger stellar populations than cluster galaxies at similar redshifts. Future work will include photometry from Hubble Space Telescope and will be aimed at establishing the evolution of the sizes and the mass-to-light ratios for the field galaxies.
Early and Late Life - Bulge-Dominated Galaxies over the Last 8-9 Gyr
Authors: Jørgensen Inger , Chiboucas Kristin , Bergmann Marcel , Toft Sune , Schiavon Ricardo 
Published: August 2016

AbstractWe present results from our investigation of galaxy evolution in dense cluster environments up to redshift z=1.3 based on high S/N ground-based spectroscopy and HST imaging of bulge-dominated galaxies: (1) An analysis of sizes, M/L ratios and line indices of galaxies in massive clusters out to z=1.3. The results are published in Jørgensen & Chiboucas (2013) and Jørgensen et al. (2014). (2) A preliminary analysis (Fig. 1) of absorption line indices, ages, metallicities and abundance ratios for galaxies in nine massive clusters out to z=0.9. New data cover three clusters at z=0.2-0.5.
Anomalies in the GRBs' distribution
Authors: Bagoly Zsolt , Horváth István , Hakkila Jon , Tóth L. Viktor 
Published: August 2016

AbstractGamma-ray bursts are the most luminous objects known: they outshine their host galaxies making them ideal candidates for probing large-scale structure. Earlier it has been found that the angular distribution of different groups of GRBs (long, intermediate and short) show deviation from the full randomness at different levels (e.g. Vavrek et al. (2008)).In the current sample there are more than 361 GRBs with position and redshift: the large scale homogeneous and isotropic distribution were checked with nearest-neighbour tests and with the two-point correlation function.
Environmental Effects on Galaxy Evolution: Multifrequency study of nearby clusters
Authors: Bravo-Alfaro H. , Venkatapathy Y. , Durret F. , Caretta C. A. , Gamez V. 
Published: August 2016

AbstractWe show first results of a multifrequency survey focused on the mechanisms driving the transformation of cluster galaxies, from late to earlier S0-types. We compare the ram-pressure effects seen on 21cm-HI images with those mechanisms affecting the old stellar disks seen on deep optical and NIR images. Our targets are the Abell clusters A85, A496, A2670, which span different relaxation degrees, masses and X-ray luminosities.
The self-regulated AGN feedback loop: the role of chaotic cold accretion
Authors: Gaspari M. 
Published: August 2016

AbstractSupermassive black hole accretion and feedback play central role in the evolution of galaxies, groups, and clusters. I review how AGN feedback is tightly coupled with the formation of multiphase gas and the newly probed chaotic cold accretion (CCA). In a turbulent and heated atmosphere, cold clouds and kpc-scale filaments condense out of the plasma via thermal instability and rain toward the black hole. In the nucleus, the recurrent chaotic collisions between the cold clouds, filaments, and central torus promote angular momentum cancellation or mixing, boosting the accretion rate up to 100 times the Bondi rate. The rapid variability triggers powerful AGN outflows, which quench the cooling flow and star formation without destroying the cool core. The AGN heating stifles the formation of multiphase gas and accretion, the feedback subsides and the hot halo is allowed to cool again, restarting a new cycle. Ultimately, CCA creates a symbiotic link between the black hole and the whole host via a tight self-regulated feedback which preserves the gaseous halo in global thermal equilibrium throughout cosmic time.