bluuebunny/crossref_metadata_2025_split huggingface dataset:
dMARCH8,aDrosophilaubiquitin E3 ligase, regulates polymodifications of tubulin in the spermiogenic pathway
Authors: Gosavi Ujwala A. S. , Chatterjee Nabanita , Nyachhyon Utsav , Pearce Brian R , Harvey Robert J , Bazinet Christopher 
Published: February 2017

ABSTRACTCiliary stability and function are regulated by the covalent addition of polyglutamate and polyglycine chains to axonemal tubulin subunits. TheDrosophilagene CG13442 encodes a predicted ubiquitin E3 ligase involved in the regulation of tubulin glycylation and glutamylation. Homologous to mammalian MARCH8, CG13442/dMARCH8is required for male fertility. Sperm indMARCH8mutant testes appear to undergo a normal individualization process but fail to be transferred to the seminal vesicle. This phenotype is very similar to that of mutants in theNtlgene, shown here to be a glycine transporter using a [3H]glycine uptake assay. Mutations indMARCH8are associated with a reduction of both polyglutamylation and polyglycylation of sperm tubulin. Polyglutamylation of tubulin is significantly increased in theNtl−background, and recovers to wild-type levels in theNtl−-dMARCH8−double mutant background, indicating that glycine and glutamate compete for some common site(s) on tubulin molecules in this system. By analogy to the regulation of the mammalian glycine transporter GlyT2 through ubiquitin-mediated trafficking between the plasma membrane and endosome,dMARCH8may targetNtland glutamate transporters, or other upstream regulators of these proteins.
International environmental NGOs and the politics of genetically modified organisms
Authors: Reis Yuna , Guedes Ana Lucia 
Published: February 2017

Purpose
The purpose of the paper is to problematize the resistance role played by international environmental non-governmental organizations (IENGOs) in the governance debate over genetically modified organisms (GMOs) to sustain that some of them are important actors in global environmental governance due to their resistance to transnational corporations.

Design/methodology/approach
The paper presents a reflection on the literature review focused on civil society and IENGOs. Accordingly, the political role of IENGOs in GMO governance is highlighted grounded on the negotiation process of the Cartagena Protocol. At the end, the authors stress that some IENGOs act as resistance actors to corporations’ practices.

Findings
The investigation of the political role played by the IENGOs in the negotiation process of the Cartagena Protocol highlighted that these actors use information to influence decision-makers and power holders, often providing know-how and material resources to local activists and social movement organizations at the domestic level. As a result, the political role played by IENGOs in GMO governance places these international actors as highly influential on the international business (IB) domain.

Originality/value
This paper highlights the importance of IENGOs as resistant actors in what regards corporations’ practices. The authors also sustain that the relationships between states, corporations and civil society actors at the governance level should be part of IB’s research agenda to advance the understanding of how civil society mobilizes, articulates and produces consent and coercion in the international domain. Therefore, the paper contributes to foster actors and voices from the margins as a relevant IB research topic.
Generation Y’s positive and negative eWOM: use of social media and mobile technology
Authors: Zhang Tingting (Christina) , Abound Omran Behzad , Cobanoglu Cihan 
Published: February 2017

Purpose
This paper aims to explore the factors that influence Generation Y’s positive or negative electronic word-of-mouth (eWOM) behavior via social media and mobile technology in the foodservice sector. Three types of dining experiences were examined: positive and negative customer experiences and negative customer service followed by a satisfactory recovery package.

Design/methodology/approach
A survey was adopted to test the factors posited to influence Generation Y consumers in these service contexts. Participants were recruited through Amazon Mechanical Turk , and multi-group structural equation modeling was performed to analyze the data.

Findings
Active use of social media and peer influence had a sweeping influence on Generation Y’s intentions to engage in eWOM about their service experiences. Technological sophistication with mobile technology influenced Generation Y to spread positive or negative service experiences, rather than satisfactory recovery experiences. Family influence had a mixed influence on Generation Y subgroups (21-24 years old vs 25-35 years old) to engage in eWOM about their satisfactory or poor service experiences. In satisfactory recovery experiences, family influence showed no significant influence on Generation Y’s eWOM behaviors.

Research limitations/implications
This study enriches online reviews and eWOM marketing theories, adds to service failure and recovery literature and enhances understanding of consumer behavior expressed by Generation Y through the empirical investigation of Generation Y consumers’ behavioral motivations to engage in eWOM through social media and mobile technology.

Practical implications
Engaging Generation Y consumers with social media campaigns and mobile technology development is not merely sufficient in eWOM marketing strategies. Instead, it is essential to create integrative peer communities to motivate Generation Y consumers to engage in eWOM marketing. Marketers need to pay attention to the mixed effects of family influences on the eWOM behaviors of subgroups of Generation Y in positive or negative service experiences.

Originality/value
Given the scarcity of consumer behavior research into Generation Y as an emerging market segment, this paper makes an incremental contribution by developing and validating a model of factors that influence Generation Y consumers’ eWOM intentions through social networking and mobile technologies in three major service contexts: positive, negative and recovery following a service failure.
Roles of negative emotions in customers’ perceived helpfulness of hotel reviews on a user-generated review website
Authors: Lee Minwoo , Jeong Miyoung , Lee Jongseo 
Published: February 2017

PurposeThis paper aims to explore how emotional expressions embedded in online hotel reviews influence consumers’ helpfulness perceptions. In particular, this study develops and tests hypotheses analyzing empirical data with a text-mining method in the context of hotels to investigate how review valence influences the perceived helpfulness of online hotel reviews and to examine the role of negative emotional expressions embedded in online consumer reviews with respect to perceived helpfulness.Design/methodology/approachThis study collected 520,668 online reviews involving 488 hotels in New York City (NYC) on Tripadvisor.com. Of these reviews, 69,202 reviews (13.29 per cent) that had received helpfulness votes were analyzed by a text mining method and negative binomial regression.FindingsThis study demonstrates that negative reviews are considered more helpful than positive reviews when potential customers read online hotel reviews for their future stay. However, when intensively negative emotions were expressed, the degree of helpfulness regarding negative reviews was diminished.Originality/valueWhile emotional expressions prevail in online consumer reviews, surprisingly little attention has been devoted to the consequences of emotional expressions in consumers’ information processing and decision-making. Due to the nature of service, given the inseparability of production and consumption, which often hinders the execution of flawless service, consumers tend to be more dependent on reviews to minimize any potential failures they may encounter later on. Therefore, this study fills a gap by demonstrating that negative reviews and emotional expressions play a more crucial role in consumers’ information processing and decision-making.
Flexible working arrangements and strategic positions in SMEs
Authors: Kotey Bernice Adei 
Published: February 2017

Purpose
Under the Australian Fair Work Act 2009, employees can request flexible working arrangements (FWAs) from their employers. Provision of FWAs is costly to small and medium enterprises (SMEs). They can, however, use FWAs to achieve competitive advantage. The purpose of this paper is to investigate strategic positions associated with FWA availability in SMEs. It also examines the effects of size and industry sector on FWA availability in SMEs.

Design/methodology/approach
With a sample of 1,541 cases comprising micro, small and medium firms from the Australian Bureau of Statistics’ Business Longitudinal Database, binary regression models were used to analyse the relationships between FWAs and the independent variables: strategic position, firm-size and industry of operation.

Findings
Flexible working hours, flexible leave arrangements and roster/shift selection were used by SMEs pursuing a strategy focussed on human resources. In contrast, a strategic focus on cost correlated negatively with paid parental leave and flexible rosters/shifts. SMEs pursuing innovation were unlikely to provide flexible leave while job sharing was less visible in SMEs focussing on quality. An industry effect was evident with working from home unlikely for firms in industry sectors where employees had to be present at work. Micro- and small-sized firms were less likely than medium firms to provide FWA to their employees.

Originality/value
SMEs with competitive positions based on human capital could use FWAs to attract the required skills. Employees in SMEs that compete on cost may benefit from FWAs in the form of temporary and casual positions.
Relative Width and Height of Handwritten Letter
Authors: Lizega Rika Joseba 
Published: February 2017

AbstractThis is an exploratory study that analyzes the width and the height of letters in two texts written by each of the 21 writers analyzed. After detrending the linear, text, and allograph trends, we proceeded to comparing the sizes obtained in different texts. The different detrended series were compared by means of correlation and t‐test. According to the results regarding the width of letters, the texts of 19 of 21 writers correlated strongly, whereas the texts of two writers did not correlate with the limits of the threshold. With regard to the height of letters, texts written by between 18 and 21 writers of 21 writers correlated strongly, whereas texts that did not correlate were within the threshold value. Regarding both the width and the height of letters, of 21 writers, texts written by between 19 and 21 individuals were found to correlate strongly.
Is the Public Corporation Really in Eclipse? Evidence from the Asia‐Pacific
Authors: Karolyi G. Andrew , Kim Dawoon 
Published: February 2017

AbstractWhile the US has experienced a 50% decline in the number of publicly listed corporations since the late 1990s, there has been an 800% increase in the Asia‐Pacific region. Notwithstanding these divergent paths, there are strikingly similar patterns in both regions in the evolution of corporate financial policies. Asia‐Pacific firms invest more in R&D and less in capital expenditures, as do US firms. They have higher cash holdings as a fraction of total assets. Dividends as a fraction of income are lower, the ranks of dividend‐paying firms in the Asia‐Pacific are declining, and, as in the US, share repurchase activity has grown. Concentration ratios of assets, income, cash, and dividends among US firms have risen to the already high levels seen in Asia‐Pacific markets. Changes in corporate financial policies that appear to reveal poorer incentives to invest cannot explain the dramatically different shifts in the landscape for public companies in the US and the Asia‐Pacific region.
VEGF165 induces differentiation of hair follicle stem cells into endothelial cells and plays a role in in vivo angiogenesis
Authors: Quan Renfu , Du Weibin , Zheng Xuan , Xu Shichao , Li Qiang , Ji Xing , Wu Ximei , Shao Rongxue , Yang Disheng 
Published: February 2017

AbstractWithin the vascular endothelial growth factor (VEGF) family of five subtypes, VEGF165 secreted by endothelial cells has been identified to be the most active and widely distributed factor that plays a vital role in courses of angiogenesis, vascularization and mesenchymal cell differentiation. Hair follicle stem cells (HFSCs) can be harvested from the bulge region of the outer root sheath of the hair follicle and are adult stem cells that have multi‐directional differentiation potential. Although the research on differentiation of stem cells (such as fat stem cells and bone marrow mesenchymal stem cells) to the endothelial cells has been extensive, but the various mechanisms and functional forms are unclear. In particular, study on HFSCs’ directional differentiation into vascular endothelial cells using VEGF165 has not been reported. In this study, VEGF165 was used as induction factor to induce the differentiation from HFSCs into vascular endothelial cells, and the results showed that Notch signalling pathway might affect the differentiation efficiency of vascular endothelial cells. In addition, the in vivo transplantation experiment provided that HFSCs could promote angiogenesis, and the main function is to accelerate host‐derived neovascularization. Therefore, HFSCs could be considered as an ideal cell source for vascular tissue engineering and cell transplantation in the treatment of ischaemic diseases.
Mesenchymal stem cell‐loaded cardiac patch promotes epicardial activation and repair of the infarcted myocardium
Authors: Wang Qiang‐li , Wang Hai‐jie , Li Zhi‐hua , Wang Yong‐li , Wu Xue‐ping , Tan Yu‐zhen 
Published: February 2017

AbstractCardiac patch is considered a promising strategy for enhancing stem cell therapy of myocardial infarction (MI). However, the underlying mechanisms for cardiac patch repairing infarcted myocardium remain unclear. In this study, we investigated the mechanisms of PCL/gelatin patch loaded with MSCs on activating endogenous cardiac repair. PCL/gelatin patch was fabricated by electrospun. The patch enhanced the survival of the seeded MSCs and their HIF‐1α, Tβ4, VEGF and SDF‐1 expression and decreased CXCL14 expression in hypoxic and serum‐deprived conditions. In murine MI models, the survival and distribution of the engrafted MSCs and the activation of the epicardium were examined, respectively. At 4 weeks after transplantation of the cell patch, the cardiac functions were significantly improved. The engrafted MSCs migrated across the epicardium and into the myocardium. Tendency of HIF‐1α, Tβ4, VEGF, SDF‐1 and CXCL14 expression in the infarcted myocardium was similar with expression in vitro. The epicardium was activated and epicardial‐derived cells (EPDCs) migrated into deep tissue. The EPDCs differentiated into endothelial cells and smooth muscle cells, and some of EPDCs showed to have differentiated into cardiomyocytes. Density of blood and lymphatic capillaries increased significantly. More c‐kit+ cells were recruited into the infarcted myocardium after transplantation of the cell patch. The results suggest that epicardial transplantation of the cell patch promotes repair of the infarcted myocardium and improves cardiac functions by enhancing the survival of the transplanted cells, accelerating locality paracrine, and then activating the epicardium and recruiting endogenous c‐kit+ cells. Epicardial transplantation of the cell patch may be applied as a novel effective MI therapy.
Using eHealth strategies in delivering dietary and other therapies in patients with irritable bowel syndrome and inflammatory bowel disease
Authors: Ankersen Dorit Vedel , Carlsen Katrine , Marker Dorte , Munkholm Pia , Burisch Johan 
Published: February 2017

AbstractHealth‐care systems around the world are facing increasing costs. Non‐adherent, chronically ill patients are one such expense incurred by health‐care providers. Web‐based home‐monitoring of patients—or eHealth—has been shown to increase adherence to medical therapy, facilitate contact between patients and health‐care professionals, and reduce time to remission for patients with inflammatory bowel disease (IBD). Web‐based treatment is a supportive tool for the health‐care provider in an out‐patient clinic. eHealth web‐programs, such as the Constant Care application, visualize disease activity in a traffic light system and empower patients to screen for disease activity, enabling them to respond appropriately to their symptoms. The eHealth screening procedure for monitoring both pediatric and adult IBD patients is based on a self‐obtained symptom score, together with a fecal biomarker for inflammation (fecal calprotectin) that the patients can measure independently using their smart phone, providing both patient and physician with an immediate disease status that they can react to instantaneously. Likewise, web applications for IBD patients, web applications for irritable bowel syndrome (IBS) patients and also IBD patients with co‐existing IBS, have proven valuable for monitoring and treating IBS symptoms with a diet low in fermentable oligo‐, di‐, monosaccharides and polyols (low‐FODMAP diet). With careful disease monitoring via the web application and increased patient adherence, eHealth might be capable of improving the natural disease course of IBD and IBS.
Explaining Export Performance through Inputs: Evidence from Aggregated Cross‐country Firm‐level Data
Authors: van der Marel Erik 
Published: February 2017

AbstractWhich trade barrier related to intermediate inputs forms a greater burden on the export performance of firms in developing countries? Using aggregated cross‐country firm‐level data covering 43 mostly developing economies, this paper estimates the marginal importance of the impact of various intermediate input trade cost barriers, namely tariffs, non‐tariff barriers (NTBs) and services barriers, on firms' export behavior. In a cross‐sectoral setting, this paper takes the firm's export performance in goods as a central focus to study the effects of these different trade barriers through the exporting firm's choice of use of intermediate inputs. The results show that the most significant trade barriers on inputs that impede export performance in developing countries are mainly NTBs and restrictions of services.
Use of TrueBeam developer mode for imaging QA
Authors: Valdes Gilmer , Morin Olivier , Valenciaga Yanisley , Kirby Niel , Pouliot Jean , Chuang Cynthia 
Published: February 2017

The purpose of this study was to automate regular Imaging QA procedures to become more efficient and accurate. Daily and monthly imaging QA for SRS and SBRT protocols were fully automated on a Varian linac. A three‐step paradigm where the data are automatically acquired, processed, and analyzed was defined. XML scripts were written and used in developer mode in a TrueBeam linac to automatically acquire data. MATLAB R013B was used to develop an interface that could allow the data to be processed and analyzed. Hardware was developed that allowed the localization of several phantoms simultaneously on the couch. 14 KV CBCTs from the Emma phantom were obtained using a TrueBeam onboard imager as example of data acquisition and analysis. The images were acquired during two months. Artifacts were artificially introduced in the images during the reconstruction process using iTool reconstructor. Support vector machine algorithms to automatically identify each artifact were written using the Machine Learning MATLAB R2011 Toolbox. A daily imaging QA test could be performed by an experienced medical physicist in min. The same test, if automated using our paradigm, could be performed in min. In the same manner, a monthly imaging QA could be performed by a physicist in min and, if fully automated, in min. Additionally, quantitative data analysis could be automatically performed by Machine Learning Algorithms that could remove the subjectivity of data interpretation in the QA process. For instance, support vector machine algorithms could correctly identify beam hardening, rings and scatter artifacts. Traditional metrics, as well as metrics that describe texture, are needed for the classification. Modern linear accelerators are equipped with advanced 2D and 3D imaging capabilities that are used for patient alignment, substantially improving IGRT treatment accuracy. However, this extra complexity exponentially increases the number of QA tests needed. Using the new paradigm described above, not only the bare minimum — but also best practice — QA programs could be implemented with the same manpower.PACS number: 87, 87.10.‐e
Evaluation of the MIM Symphony treatment planning system for low‐dose‐rate‐ prostate brachytherapy
Authors: Dhanesar Sandeep K. , Lim Tze Y. , Du Weiliang , Bruno Teresa L. , Frank Steven J. , Kudchadker Rajat J. 
Published: February 2017

MIM Symphony is a recently introduced low‐dose‐rate prostate brachytherapy treatment planning system (TPS). We evaluated the dosimetric and planning accuracy of this new TPS compared to the universally used VariSeed TPS. For dosimetric evaluation of the MIM Symphony version 5.4 TPS, we compared dose calculations from the MIM Symphony TPS with the formalism recommended by the American Association of Physicists in Medicine Task Group 43 report (TG‐43) and those generated by the VariSeed version 8.0 TPS for iodine‐125 (I‐125; Models 6711 and IAI‐125A), palladium‐103 (Pd‐103; Model 200), and cesium‐131 (Cs‐131; Model Cs‐1). Validation was performed for both line source and point source approximations. As part of the treatment planning validation, first a QA phantom (CIRS Brachytherapy QA Phantom Model 045 SN#D7210‐3) containing three ellipsoid objects with certified volumes was scanned in order to check the volume accuracy of the contoured structures in MIM Symphony. Then the DICOM data containing 100 patient plans from the VariSeed TPS were imported into the MIM Symphony TPS. The 100 plans included 25 each of I‐125 pre‐implant plans, Pd‐103 pre‐implant plans, I‐125 Day 30 plans (i.e., from 1 month after implantation), and Pd‐103 Day 30 plans. The dosimetric parameters (including prostate volume, prostate D90 values, and rectum V100 values) of the 100 plans were calculated independently on the two TPSs. Other TPS tests that were done included verification of source input and geometrical accuracy, data transfer between different planning systems, text printout, 2D dose plots, DVH printout, and template grid accuracy. According to the line source formalism, the dosimetric results between the MIM Symphony TPS and TG‐43 were within 0.5% (0.02 Gy) for . In the line source approximation validation, MIM Symphony TPS values agreed with VariSeed TPS values to within 0.5% (0.09 Gy) for . Similarly, in point source approximation validation, the MIM Symphony values agreed to within 1% of the TG‐43 and VariSeed values for . The volume calculations obtained from the MIM Symphony TPS for the CIRS Brachytherapy QA Phantom were within 1% of the actual volume of the phantom. For the clinical cases, the volume and dosimetric parameter calculations for the prostate and rectum did not differ substantially between the pre‐implant and Day 30 plans. Overall, our investigations showed negligible differences in dosimetry calculations and planning parameters between the two TPSs. The tests done to check the performance of the MIM Symphony TPS, such as the library data, data transfer, isodose and DVH printout, were found to be satisfactory. On the basis of these results, we conclude that the MIM Symphony TPS can be used as an alternative to the VariSeed TPS for low‐dose‐rate prostate brachytherapy.PACS numbers: 87.53.Jw; 87.55.D‐, 87.55.Qr