bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of proximate composition, and mineral content of five soybean varieties in two research centers
Authors: Ateye Mahamed Dol , Ali Abdulkarim Mohammed , Hassen Shamsedin Mahdi , Jama Hodo Mohamed 
Published: October 2024

Abstract

Soybean is a valuable source of high-quality protein and oil, widely used in human diets. This study aimed to evaluate the proximate composition and mineral content of soybean varieties from two Ethiopian research centers and Dolo-Ado. Mature soybean seeds were collected from Kelafo, Dolo-Ado, and local markets. Proximate composition (moisture, ash, fat, protein, fiber) and mineral content (calcium, iron, magnesium, zinc) were analyzed using standard methods, with triplicate measurements. Data were analyzed using Design Expert version 13 and Excel 2019. Moisture content ranged from 4.78–7.34%, protein 19.65–30.35%, fat 5.37–21.61%, and fiber 3.75–6.29%. Calcium ranged from 48.9–157.2 mg/100g, iron 5.37–12.06 mg/100g, magnesium 658.5–2429.1 mg/100g, and zinc 3.79–6.45 mg/100g. Varieties K-Pawa 1, K-Pawa 3, D-Pawa 3, and D-Gezale exhibited high nutritional value, making them suitable for addressing protein-energy malnutrition and mineral deficiencies, particularly in vulnerable populations such as infants and lactating mothers.
Unveiling the Dynamics of Alternative Investment Funds (AIFs): A Comprehensive Analysis of Their Role in Capital Formation in the Indian Financial Landscape
Authors: Paul Vethamuthu Richard 
Published: October 2024

Abstract

This study delves into the intricate dynamics of Alternative Investment Funds (AIFs) in the context of the Indian financial landscape. The primary focus is on understanding how these factors influence gross capital formation, making AIFs increasingly integral to capital-raising activities in the Indian economy. By employing pooled data, this research sheds light on the multifaceted investments made by AIFs and their role in shaping the future of capital formation. The study reveals that AIFs, with their encompassing categories I, II and III of investment avenues, can play a pivotal role in transforming traditional investment practices. The findings underscore the significance of AIFs in offering alternative avenues for investment, providing a way forward for traditional investors. The implications of these results extend to policy considerations, particularly for developing countries exploring innovative approaches to capital formation.
Comparison of Plasma Corin Levels in Gestational Hypertensive Patients, Normotensive Pregnant and Normotensive Non-Pregnant Women
Authors: Humaira Fayyaz  , Al-Aqmer Noora Hassan Hezam , , Sibgha Zulfiqar  
Published: October 2024

Background: Multiple factors play role in gestational hypertension including vasopressin production and Renin-angiotensin-aldosterone system activation. Opposing these effects, corin plays an important role in mediating natriuretic peptide biosynthesis cascade which is an important factor in regulating fluid balance and blood pressure. Corin levels have been studied in relation to gestational hypertension and results were controversial.Objective:: This study aimed at comparing plasma corin levels in gestational hypertensive patients, normotensive pregnant women, and normotensive non-pregnant women.Methods: This was a cross sectional comparative study conducted for one year at Shaikh Zayed Medical Complex. By convenient sampling, ninety women aged 18-45 years were included; thirty pregnant (primigravida and multigravida) with gestational hypertension, thirty pregnant (primigravida and multigravida) normotensive women, and thirty non-pregnant normotensive women. Patients with gestational diabetes, renal diseases, hypertension before pregnancy, and other cardiovascular diseases were excluded. Informed consent was taken and demographic data was recorded. Three ml of blood was taken from each participant and corin levels were measured using ELISA kit. Data was analysed using SPSS 24.Results: A significant difference was found in BMI among the three groups with the gestational hypertensive patients having the highest BMI (p-value < 0.05). There was no significant difference in gravid and parity count between gestational hypertensive patients and pregnant normotensive women. No significant difference was found in corin levels among the three groups and there was no significant correlation between corin levels and age nor between corin levels and BMI.Conclusion: There is no significant difference in plasma corin levels amongst gestational hypertensive patients, normotensive pregnant women, and normotensive non-pregnant women.
Orexin Receptor System: Molecular Insights and Therapeutic Implications
Authors: Sharma Prachi , Choudhary Gunjan , Sachdeva Monika , Mehta Geetika , Tripathi Rashmi 
Published: October 2024

Abstract:
Neuropeptide neurotransmitters, orexins, are produced in the lateral hypothalamus.
They are extensively dispersed throughout the central nervous system, except the cerebellum and
peripheral nervous system. Orexin works by attaching themselves to G-protein-coupled receptors:
orexin receptor 1 (OXR1) & orexin receptor 2 (OXR2). They play a role in the regulation of energy
homeostasis, appetite, sleep-wake cycles, and other disorders like cancer, ischemic stroke, depression,
Alzheimer's disease, and narcolepsy. Prepro-orexin peptide undergoes proteolytic breakdown
to create these neurotransmitters. Orexin receptor antagonists decrease both non-rapid eye
movement and rapid eye movement sleep, which increases awake through the lateral preoptic region.
It encourages eating and supports the control of feeding habits, thus can be used in the treatment
of obesity. In Alzheimer's disease, orexin enhances tau protein-mediated neurodegeneration
and beta-amyloid buildup by interacting with the biomarkers of the illness found in the cerebrospinal
fluid (beta-amyloid/tau proteins). It also lessens neuroinflammation, enhances cognitive performance,
and prevents the formation of plaque, which contains beta-amyloid and tau proteins.
Revolutionizing Quinolone Development for DNA Gyrase Targeting; Discovering the Promising Approach to Fighting Microbial Infections
Authors: . Shafiurrahman , Hasan Syed Misbahul , Singh Kuldeep , Kumar Arun , . Suvaiv , Bano Jeba , Shahanawaz Mo. , Ahmad Sana , Kushwaha Shom Prakash 
Published: October 2024

Abstract:
DNA gyrase is a type II topoisomerase enzyme that can cause negative supercoiling in DNA by using the energy produced by ATP hydrolysis. There are two main types of topoi-somerases: type I and type II. Type I enzymes cut a single strand of DNA and are further clas-sified as type IA if they connect to a 5′ phosphate of DNA, or type IB if they link to a 3′ phos-phate. Type II topoisomerases break both strands, creating a staggered double-strand break.
Antimicrobial resistance is a major concern for the global healthcare system. Resistance is the ability of microorganisms to neutralize and withstand antimicrobial drugs previously used to treat microbial infections. Some known classes of DNA gyrase inhibitors are coumarins, cyclo-thialidines, and quinolones. Antimicrobial medicines such as quinolones have been widely used to treat microbiological diseases. However, the increased use of quinolones has led to the emer-gence of quinolone-resistant bacteria, which poses a serious risk to public health. Microorgan-isms can cause resistance due to changes in the target enzymes, DNA gyrase, and topoisomerase IV, which are responsible for transcription and DNA replication. Additionally, differences in drug entry and efflux may also play a role in resistance. Plasmids that produce the Qnr protein can mediate resistance to quinolones by protecting the quinolone targets from inhibition. This review aims to revolutionize the discovery of quinolone-based antibiotics, specifically targeting DNA gyrase, a critical enzyme in bacterial DNA replication, to enhance the efficacy and spec-ificity of anti-microbail agents against microbial infections.
Correlation between Cognitive Impairment and Peripheral Biomarkers - Significance of Phosphorylated Tau and Amyloid-β in Alzheimer’s Disease: A New Insight
Authors: Sarkar Subhajit , Bhui Utpal , Kumar Bimlesh , Ashique Sumel , Kumar Prashant , Sharma Himanshu , Bhowmick Mithun , Pal Radheshyam , Kumar Tinku 
Published: October 2024

Abstract:
The correlation between elevated levels of amyloid-β and phosphorylated
tau (p-tau) protein and AD is widely recognized. A rise in pTau and amyloid-
β levels aids in separating AD from other neurodegenerative conditions. In
this study, we have assessed the correlation between cognitive impairment and
peripheral biomarkers, tau and amyloid-β levels, in AD patients with mild
Alzheimer's disease in order to develop protein-based markers in a more useful
way. An enzyme-linked immunosorbent assay has been used to determine the
levels of tau and p-tau in the serum of the different groups and it has revealed
their levels to be noticeably greater in AD compared to mild AD and even higher
compared to elderly controls. Based on the cutoff levels for tau, p-tau, and
amyloid-β in patients with AD and mild AD, having high sensitivity and specificity,
which have been described in numerous studies by respective International
Research Groups (with the greatest number of pieces of available evidence),
the plasma concentration of these proteins can be used as a diagnostic indicator
for AD and mild AD. These levels may also offer a practical guide to their implementation
in the clinical routine.
“Open the world of art to residents and guests of the city” about the artistic work of N. I. Verkhoturov in the Irkutsk province at the turn of the 19th – 20th centuries
Authors: Tkachev V. V. 
Published: October 2024

Relevance. Throughout the entire period of development of the urban environment, artists changed their attitude towards artistic spaces. N. I. Verkhoturov is one of many who not only sought to increase the interest of residents in his works, but also to create an artistic environment in the Irkutsk province. These aspects strengthen and intensify the work on studying the artistic heritage of the master, which has been preserved in the archives and museums of Irkutsk.The purpose is to present the work of N. I. Verkhoturov on creating artistic spaces for the interaction of artists with visitors to exhibitions in the Irkutsk province at the turn of the 19th - 20th centuries.Objectives: to identify materials about the activities of N. I. Verkhoturov, within the framework of which the process of coordinating the work of the creative community is described; explore artistic events aimed at disseminating knowledge about Russian art; analyze archival materials in the context of their influence on the attitude of N. I. Verkhoturov in the construction of pedagogical and creative activities, cooperation with artists and collectors.Methodology. The work is based on an integrated approach. The principles of historicism, objectivity, and scientific character are taken into account; problem-chronological and historical-genetic methods are used.Results. As part of the work in the archives of the Irkutsk region, materials were identified that describe the activities of N. I. Verkhoturov at the turn of the 19th - 20th centuries in creating educational institutions and organizing exhibition pavilions. Considering stories related to the master’s participation in events, one can be convinced of a change in the public’s attitude towards artists, museums, and art collections.Conclusions. N.I. Verkhoturov participated in the creation of a drawing school, the work of educational institutions and public and scientific organizations. As a result of interaction with artists and collectors, centers of artistic life appeared in the Irkutsk province. Studying publications and materials on the history of art and the urban environment, the artist showed interest in creating educational institutions, workshops, and maintaining the work of museums and art galleries.
Challenging (appealing) decisions, actions (inaction) of state bodies (their officials) and other persons (organizations) involved in the process of state registration of a legal entity
Authors: Gabov A. V. 
Published: October 2024

Relevance. A legal entity is a popular legal tool for citizens of the Russian Federation to implement their economic and other interests, as evidenced by the statistical data of the Federal Tax Service of Russia in terms of state registration of legal entities. The scale of interaction between applicants and authorized bodies, as well as persons (organizations) involved in the state registration process, the current (far from optimal) state of legislation on state registration, which creates a favorable basis for the emergence of conflicts and disputes, suggests the need to develop effective forms and means of protecting the rights and legally protected interests of applicants, which, unfortunately, does not exist yet.The purpose of the article is to identify key problems and trends in the development of legislation in terms of appealing (challenging) decisions, actions (inaction) of state bodies (their officials) and other persons (organizations) involved in the process of state registration of a legal entity.Objectives of the study: to analyze the development of legislation in terms of appealing (contesting) decisions, actions (inaction) of state bodies (their officials) and other persons (organizations) involved in the process of state registration of a legal entity; to identify the directions of such development, to understand the reasons for their formation; to identify the main problems and formulate ways to overcome them.Methodology. The article is written on the basis of traditional methods for legal research; the study is based on a systems analysis.Results. It has been established that the existing regulations were formed to a greater extent "spontaneously", in the absence of a special political and legal basis; inconsistency in the provisions of the main regulatory documents has been revealed; problems arising with pre-trial appeal of decisions (actions / inaction) of authorized bodies, actions of the MFC and its employees have been identified; problems with appealing / challenging the actions / inaction of notaries are indicated.Conclusion. The study shows the need for a systemic reform of the rules governing issues of appealing (challenging) decisions, actions (inaction) of state bodies (their officials) and other persons (organizations) involved in the state registration process; directions for appropriate changes are proposed.
Is it possible to raise the question of the responsibility of the court?
Authors: Filippov P. М. 
Published: October 2024

Relevance. Responsibility of the court for unlawful decisions has always been a matter of key concern. Since the times of Roman law which established the responsibility of judges for negligent performance of their duties to the parties, this issue with its diversified constituents has demanded to be thought over. The author reasons upon the need to establish social responsibility of judges, as well as the need to consolidate the principle of good faith in relation to their activities in the consideration and resolution of disputes.The purpose of the research is to establish the meaning and content of the court responsibility in the framework of civil proceedings.The research objectives are to determine social prerequisites needed to determine the responsibility of courts; to identify the importance of judges’ fair practices in determining their responsibility; and to critically comprehend the axiom "Jura novit curia" in the context of the topic under study.Methodology. The research is based on the universal dialectical method of scientific cognition with applying analysis, deduction, description, generalization and formal legal methods.The research resulted in the developed author's vision of the responsibility of courts. The author declares that the existence of social responsibility makes any person liable, so a judge must first of all foresee adverse consequences of his/her behavior. As the issue of good faith in terms of the judge’s conduct is not declared in procedural codes, the matter of the indisputable authority of the judicial system remains unresolved.Conclusion. The paper frames the author's conclusion generated by many years of research about the need for a radical transformation of the institution of responsibility of courts for unlawful decisions beyond the framework of procedural appeal that is established by law.
Civil law means of implementing state policy in the field of culture
Authors: Mokhov A. A. 
Published: October 2024

Relevance. The combination of external and internal threats in the field of mental (socio-cultural) security requires urgent measures in terms of correcting the state's cultural policy. Modern strategic planning documents in one way or another affect the ongoing cultural policy, identify its defects. In this regard, proposals are increasingly being made to prepare and adopt a Federal law "On Culture" that is adequate to modern geopolitical and socio-cultural realities. Ensuring mental security, preserving and strengthening traditional Russian spiritual and moral values, along with public measures, also require increased attention to civil law means of implementing state policy in the field of culture.The purpose is to develop theoretical recommendations for improving legislation governing the organization and holding of cultural, entertainment and other cultural events.Objectives: to establish the influence of civil law means aimed at ensuring state policy in the field of culture; to determine an approximate catalog, a list of means that can be used by the legislator in the development and adoption of the Federal Law "On Culture".Methodology. In the process of working on the study, the dialectical-materialistic method, the systematic method, the method of analysis and synthesis, formal legal, as well as comparative legal methods were used.Results of the study are reflected in the formulated proposals aimed at improving the legislation on culture by expanding the possible range of civil law tools that ensure a coordinated state policy in the field of culture.Conclusion. In the course of the study, a justification was presented for the need to introduce into the legislation on culture and the practice of organizing an appropriate type of activity, holding cultural and entertainment events and similar events such civil legal means as: contracts, corporate and ethical acts, as well as starting points on civil liability.
Legal regulation of intellectual property protection for artificial neural networks
Authors: Ogarok M. A. 
Published: October 2024

Relevance. Fundamental differences in the processes of development and maintenance of artificial neural networks from the algorithmic approach determine the relevance of the development of the existing scientific and methodological platform for solving technological and regulatory issues in the field of software development and legal protection of intellectual property of artificial intelligence systems.The purpose of the study is to formulate scientifically based conclusions that determine the directions for solving the scientific problem of legal protection of intellectual property on artificial neural networks.Objectives: to formulate a list of scientific tasks necessary for solving the scientific problem of legal protection of intellectual property rights to artificial neural networks; to develop proposals for improving the regulatory framework for registering intellectual property rights to artificial neural networks.Methodology. The methodological basis of scientific research was the dialectical method of understanding the phenomena and processes of the surrounding reality.Results. The obtained results of the study provide the opportunity to improve the regulatory framework establishing the basic principles of legal relations arising during the registration of intellectual property rights to artificial neural networks.Conclusion. The solution to the problem of legal protection of intellectual property on artificial neural networks should be based on the improvement of the existing regulatory framework for the registration of intellectual property rights, as well as regulatory acts that determine the rules for registering and securing intellectual property rights to arrays of training sample data and (or) arrays of trained models of artificial neural networks, as well as to the topology of integrated circuits of neuromorphic processors.
Strategi Pengelolaan Sampah di Kafe Rantiang Kota Padang
Authors: Fadila Shanista , Anzusi Syannajma , Effendi Aisyah , Aidil Muhammad , Wulandari Eka Pratiwi , Untari Elbunia , Emilza Lovia Phica Yola , Prayoga Ferry Ferdian , Gea Reri Damai , Nugraha Muhammad Ridho , Wahyuni Ameydea Nistrail 
Published: October 2024

Artikel ini mengkaji tentang strategi dan inovasi dalam mengelola sampah di Kafe Rantiang yang berlokasi di Jalan Parkit, Kota Padang. Penelitian ini dilakukan melalui observasi langsung, wawancara dengn pemilik kafe serta studi literatur untuk menemukan strategi dan inovasi yang tepat untuk mengatasi permasalahan yang ditemukan. Tujuan penulisan ini untuk menggali strategi dan inovasi yang dapat dilakukan untuk mengelola sampah terutama sampah yang ada di Kafe Rantiang dalam meminimalkan dampak lingkungan dari limbah sampah yang dihasilkan. Penelitian ini memberikan wawasan mendalam tentang bagaimana strategi dan inovasi dapat menjadi kunci dalam menciptakan model pengelolaan sampah yang berkelanjutan di sektor usaha kuliner. Implikasi temuan ini dapat memberikan inspirasi dan panduan bagi pelaku usaha serupa serta pemerintah daerah dalam upaya mencapai tujuan pembangunan berkelanjutan.
A note on the nomenclatural representation of plant transcription factors, and deviations thereof
Authors: Teixeira da Silva Jaime A. 
Published: October 2024

Abstract
Plant transcription factors (TFs) are integral proteins associated with gene transcription. That ability arises after TFs bind to specific DNA sequences, such as promoters, responding positively or negatively to a multitude of endogenous and exogenous factors or stressors. For this reason, in plants, the vast majority of TFs are associated with growth, development, and responses to biotic and abiotic stresses. As is commonly known, the genes coding for TFs are written in uppercase italics, whereas the resulting proteins are written in lowercase, such as OsWRKY28 and OsWRKY28, respectively for a member of the WRKY TF family in rice (Oryza sativa L.). However, despite the existence of some conventions for the nomenclature of TFs, some deviation from these norms has been observed in the literature. Several cases are highlighted, primarily related to NAC TFs. These cases emphasize the need for stricter quality control of literature pertaining to the nomenclature of plant TFs.