bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overdose in young children treated with anti-reflux medications: Poisons enquiry evidence of excess 10-fold dosing errors with ranitidine
Authors: Crawford C , Anderson M , Cooper G , Jackson G , Thompson J , Vale A , Thomas SHL , Eddleston M , Bateman DN 
Published: April 2017

Background: Accidental drug overdose is a common problem in young children. We examined the influence of formulation and dose in enquiries for different gastro-oesophageal reflux disease treatments in children under 5 years to the UK’s National Poisons Information Service. Methods: Overdose characteristics with ranitidine, omeprazole or domperidone were compared with those of metoclopramide and the H-1 antagonist chlorphenamine, for the period 1 July 2007 to 30 June 2015. Results: There were a total of 1092 ranitidine, 618 domperidone and 1193 omeprazole cases; 669, 281 and 424, respectively, were single agent enquiries; of these 77% (517) of ranitidine, 52% (145) domperidone and 32% (135) omeprazole cases occurred in children <5 years. In comparison, 17% (34/424) of metoclopramide and 53% (533/1013) of chlorphenamine were <5 years; 79% (410/517) of ranitidine overdose enquiries in children <5 years were under 6 months of age, higher than domperidone (68/145, 47%; p < 0.05), omeprazole (8/135, 6%), chlorphenamine (13/553, 2%) or metoclopramide (1/34, 3%) (all p < 0.01). In children aged <6 months, 101 were 10-fold overdoses, 86 with ranitidine. Conclusions: Tenfold overdoses in children (<5 years) were a feature of ranitidine enquiries, likely due to the high concentration of the syrup. This has relevance to other liquid formulations used for non-licenced indications in young children. Such therapeutic errors cause significant carer anxiety and healthcare utilization. Assistance is needed from manufacturers and legislators in modifying formulation so that drugs can be safely used in young children. Education of prescribers and carers is also needed to reduce the incidence of such errors that cause significant carer anxiety and healthcare utilization.
Outcomes of Surgeries Performed in Physician Offices Compared With Ambulatory Surgery Centers and Hospital Outpatient Departments in Florida
Authors: Ohsfeldt Robert L , Li Pengxiang , Schneider John E , Stojanovic Ivana , Scheibling Cara M 
Published: April 2017

Background: The proportion of outpatient surgeries performed in physician offices has been increasing over time, raising concern about the impact on outcomes. Objective: To use a private insurance claims database to compare 7-day and 30-day hospitalization rates following relatively complex outpatient surgical procedures across physician offices, freestanding ambulatory surgery centers (ASCs), and hospital outpatient departments (HOPDs). Methods: A multivariable logistic regression model was used to compare the risk-adjusted probability of hospitalization among patients after any of the 88 study outpatient procedures at physician offices, ASCs, and HOPDs over 2008-2012 in Florida. Results: Risk-adjusted hospitalization rates were higher following procedures performed in physician offices compared with ASCs for all procedures grouped together, for most procedures grouped by type, and for many individual procedures. Conclusions: Hospitalizations following surgery were more likely for procedures performed in physician offices compared with ASCs, which highlights the need for ongoing research on the safety and efficacy of office-based surgery.
Activation of GPR15 and its involvement in the biological effects of smoking
Authors: Kõks Sulev , Kõks Gea 
Published: April 2017

Smoking is one of the most significant modifiable environmental risk factors for many diseases. Smoking causes excessive mortality worldwide. Despite decades of long research, there has not been a clear understanding regarding the molecular mechanism that makes smoking harmful to health. Some recent studies have found that smoking influences most significantly the expression and methylation of GPR15. GPR15 is an orphan receptor that is involved in the regulation of the innate immunity and the T-cell trafficking in the intestinal epithelium. Further studies have confirmed that GPR15 is very strongly involved in smoking and smoking-induced molecular changes. Therefore, the altered expression and epigenetic regulation of GPR15 could have a significant role in the health impact of smoking. Impact statement The review describes an orphan receptor GPR15 that has recently been found to be influenced by smoking. This makes GPR15 very sensitive and adequate biomarker for smoking and smoking studies. Also, activation of GPR15 by smoking could help to explain its effects on health.
Thirty-Day Readmission Risk Factors Following Single-Level Transforaminal Lumbar Interbody Fusion (TLIF) for 4992 Patients From the ACS-NSQIP Database
Authors: Garcia Roxanna M. , Khanna Ryan , Dahdaleh Nader S. , Cybulski George , Lam Sandi , Smith Zachary A. 
Published: April 2017

Study Design: Retrospective cohort study. Objective: To describe the readmission rate and identify risk factors associated with 30-day readmission after transforaminal lumbar interbody fusion (TLIF) surgery. Methods: Patients who underwent elective single level TLIF surgery from 2011 to 2013 were identified in the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Emergency or trauma cases were excluded. Preoperative, intraoperative, and postoperative variables were extracted. A multivariate binary regression identified predictors correlated with 30-day readmission. Results: A total of 4992 patients were included in the analysis. The overall 30-day readmission rate was 5.51% (275/4992) for readmissions reported between 2011 to 2013. The mean age of patients readmitted was 62.40 years (standard error [SE] = 0.78) and 60.92 years (SE = 0.20) among those whom were not readmitted ( P = .05). The top three causes for readmission included postoperative pain control, deep or superficial surgical site infections. Predictors associated with 30-day readmission in a multivariate analysis included female gender (odds ratio [OR] = 1.27, 95% CI = 0.97-1.65), history of severe chronic obstructive pulmonary disease (OR = 1.81, 95% CI = 1.11-2.96), and in the postoperative period, American Society of Anesthesiologists class (OR = 1.30, 95% CI = 1.04-1.63), presence of superficial surgical site infection (OR= 18.23, 95% CI = 10.36-32.08), or urinary tract infection (OR = 4.93, 95% CI = 2.84-8.58). Conclusions: The readmission rate, risk factors, and causes following TLIF surgery are comparable to other lumbar spinal procedures reported from the ACS-NSQIP database.
Clinical Application of Ceramics in Anterior Cervical Discectomy and Fusion: A Review and Update
Authors: Zadegan Shayan Abdollah , Abedi Aidin , Jazayeri Seyed Behnam , Bonaki Hirbod Nasiri , Vaccaro Alexander R. , Rahimi-Movaghar Vafa 
Published: April 2017

Study Design: Narrative review. Objectives: Anterior cervical discectomy and fusion (ACDF) is a reliable procedure, commonly used for cervical degenerative disc disease. For interbody fusions, autograft was the gold standard for decades; however, limited availability and donor site morbidities have led to a constant search for new materials. Clinically, it has been shown that calcium phosphate ceramics, including hydroxyapatite (HA) and tricalcium phosphate (TCP), are effective as osteoconductive materials and bone grafts. In this review, we present the current findings regarding the use of ceramics in ACDF. Methods: A review of the relevant literature examining the clinical use of ceramics in anterior cervical discectomy and fusion procedures was conducted using PubMed, OVID and Cochrane. Result: HA, coralline HA, sandwiched HA, TCP, and biphasic calcium phosphate ceramics were used in combination with osteoinductive materials such as bone marrow aspirate and various cages composed of poly-ether-ether-ketone (PEEK), fiber carbon, and titanium. Stand-alone ceramic spacers have been associated with fracture and cracks. Metallic cages such as titanium endure the risk of subsidence and migration. PEEK cages in combination with ceramics were shown to be a suitable substitute for autograft. Conclusion: None of the discussed options has demonstrated clear superiority over others, although direct comparisons are often difficult due to discrepancies in data collection and study methodologies. Future randomized clinical trials are warranted before definitive conclusions can be drawn.
What Influences Mental Illness? Discrepancies Between Medical Education and Conception
Authors: Einstein Evan Hy , Klepacz Lidia 
Published: April 2017

Objective: This preliminary study examined the differences between what was taught during a formal medical education and medical students’ and psychiatry residents’ conceptions of notions regarding the causes and determinants of mental illness. Methods: The authors surveyed 74 medical students and 11 residents via convenience sampling. The survey contained 18 statements which were rated twice based on truthfulness in terms of a participant’s formal education and conception, respectively. Descriptive statistics and a Wilcoxon signed rank test determined differences between education and conception. Results: Results showed that students were less likely to perceive a neurotransmitter imbalance to cause mental illness, as opposed to what was emphasized during a formal medical education. Students and residents also understood the importance of factors such as systemic racism and socioeconomic status in the development of mental illness, which were factors that did not receive heavy emphasis during medical education. Furthermore, students and residents believed that not only did mental illnesses have nonuniform pathologies, but that the Diagnostic and Statistical Manual of Mental Disorders also had the propensity to sometimes arbitrarily categorize individuals with potentially negative consequences. Conclusions: If these notions are therefore part of students’ and residents’ conceptions, as well as documented in the literature, then it seems appropriate for medical education to be further developed to emphasize these ideas.
Prevalence of Early Minor and Major Complications After Reverse Shoulder Arthroplasty According to the Pathology in Treatment and Comorbidities
Authors: Almeida Alexandre , Piluski Paulo César Faiad , Lech Osvandré Luiz Canfield , Carvalho Eurico Rafael Gonçalves , Rodrigues Carlos Castilhos , de Almeida Letícia Agostini 
Published: April 2017

Objective To assess the prevalence of early minor and major complications (MMC) of reverse shoulder arthroplasty (RSA) according to the underlying pathology responsible for the surgical indication. Methods Between August 2009 and September 2015, 75 shoulders were submitted to RSA. Revision surgeries and patients with less than 2 months of follow-up were excluded. We analyzed 72 shoulders. The cuff tear arthropathy (CTA) represented 56.9% of cases and proximal humeral 4-part fractures (4PF) represented 13.8%. The index of MMC was analyzed according to the indication of basic pathology and the presence of rheumatoid arthritis, diabetes mellitus, and obesity. Results The evaluation was performed with a median of 11.5 months. Minor complications were found in 14 patients (19.4%) and major complications in 29 patients (40.3%). The statistical analysis was performed adding the contents of MMC—47.2%. In CTA patients, there were 43.9% (18/41) of MMC. In all other joint diseases, there were 51.6% (16/31) MMC. There was no statistical difference in the prevalence of MMC among the cases of CTA and the other diseases. There was a tendency, although not significant, of lower prevalence of MMC in cases of 4PF compared to CTA patients. Patients with rheumatoid arthritis and diabetes mellitus did not present with a higher prevalence of MMC, and obesity significantly increased the prevalence of MMC. Conclusion It was not possible to demonstrate a higher prevalence of MMC according to the pathology being treated. The presence of obesity significantly increased the prevalence of MMC. Rheumatoid arthritis and diabetes mellitus did not increase the prevalence of MMC.
Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL
Authors: Ding Wei , LaPlant Betsy R. , Call Timothy G. , Parikh Sameer A. , Leis Jose F. , He Rong , Shanafelt Tait D. , Sinha Sutapa , Le-Rademacher Jennifer , Feldman Andrew L. , Habermann Thomas M. , Witzig Thomas E. , Wiseman Gregory A. , Lin Yi , Asmus Erik , Nowakowski Grzegorz S. , Conte Michael J. , Bowen Deborah A. , Aitken Casey N. , Van Dyke Daniel L. , Greipp Patricia T. , Liu Xin , Wu Xiaosheng , Zhang Henan , Secreto Charla R. , Tian Shulan , Braggio Esteban , Wellik Linda E. , Micallef Ivana , Viswanatha David S. , Yan Huihuang , Chanan-Khan Asher A. , Kay Neil E. , Dong Haidong , Ansell Stephen M. 
Published: April 2017

Key Points
Pembrolizumab was first shown to be clinically active in CLL patients with RT. PD-1 and PD-L1 expression in tumor microenvironment are promising biomarkers to select RT patients for PD-1 blockade.
Isomorphism classes for higher order tangent bundles
Authors: Suri Ali 
Published: April 2017

Abstract
The tangent bundle TkM of order k of a smooth Banach manifold M consists of all equivalence classes of curves that agree up to their accelerations of order k. In previous work the author proved that TkM, 1 ≤ k ≤∞, admits a vector bundle structure on M if and only if M is endowed with a linear connection, or equivalently if a connection map on TkM is defined. This bundle structure depends heavily on the choice of the connection. In this paper we ask about the extent to which this vector bundle structure remains isomorphic. To this end we define the k-th order differential Tkg : TkM ⟶ TkN for a given differentiable map g between manifolds M and N. As we shall see, Tkg becomes a vector bundle morphism if the base manifolds are endowed with g-related connections. In particular, replacing a connection with a g-related one, where g : M ⟶ M is a diffeomorphism, one obtains invariant vector bundle structures. Finally, using immersions on Hilbert manifolds, convex combinations of connection maps and manifolds of Cr
maps we offer three examples for our theory, showing its interaction with known problems such as the Sasaki lift of metrics.
Young Stars in the Camelopardalis Dust and Molecular Clouds. VI. YSOs Verified by Spitzer and Akari Infrared Photometry
Authors: Straižys V. , Kazlauskas A. 
Published: April 2017

AbstractUsing photometric data of infrared surveys, young stellar object (YSO) status is verified for 141 objects selected in our previous papers in the Cassiopeia and Camelopardalis segment of the Milky Way bounded by Galactic coordinates (l, b) = (132-158°, ±12°). The area includes the known star- forming regions in the emission nebulae W3, W4 and W5 and the massive YSO AFGL490. Spectral energy distribution (SED) curves between 700 nm and 160 μm, constructed from the GSC 2, 2MASS, IRAS, MSX, Spitzer and AKARI data, are used to estimate the evolutionary stages of these stars. We confirm the YSO status for most of the objects. If all of the investigated objects were YSOs, 45% of them should belong to Class I, 41% to class II and 14% to Class III. However, SEDs of some of these objects can be affected by nearby extended infrared sources, like compact H II regions, infrared clusters or dusty galaxies.
Some Diptera newly recorded from Ukraine
Authors: Oboňa Jozef , Dvořák Libor , Manko Peter , Mariychuk Ruslan , Starý Jaroslav , Tkoč Michal 
Published: April 2017

AbstractResults of faunistic research of eight selected dipteran families (Bibionidae, Blephariceridae, Dixidae, Limoniidae, Pediciidae, Platypezidae, Ptychopteridae, and Rhagionidae) in the Uzh River Basin (Ukraine) are presented thanks to the support by the FAN (B) - Förderkreis für allgemeine Naturkunde (Biologie) in the framework of the project “Ephemeroptera, Plecoptera, Diptera biodiversity trip along the Uzh river, Ukraine”. Altogether 16 species are recorded as new to the fauna of Ukraine in the present paper. One species is newly recorded of the families Blephariceridae, Pediciidae, and Ptychopteridae, and two species each of the families Limoniidae and Bibionidae. Three species each belong to the families Dixidae, Platypezidae, and Rhagionidae.
Schellings Philosophische Briefe über Dogmatismus und Kriticismus
Authors: Pedro Teresa 
Published: April 2017

Abstract
The aim of the paper is to offer a pragmatic interpretation of Schelling’s Philosophical Letters on Dogmatism and Criticism by pointing out some important similarities with James’s Pragmatism. A New Name for Some Old Ways of Thinking. Both authors share the assumption that fundamental philosophical conflicts cannot receive a theoretical solution. Most notably, I interpret Schelling’s idea of the two different ‘demands’ (Forderungen) that result from the two philosophical systems of dogmatism and criticism, as being similar to James’s idea of ‘practical consequences’ of a theoretical statement. Both Schelling’s conception of the ‘demand’ and James’s idea of ‘practical consequences’ fulfil a double function: they bring the crucial point of disagreement between opposite philosophical positions to light and open the possibility of settling the conflict. I argue that a pragmatic interpretation of Schelling helps in better understanding his specific conception of the primacy of the practical.
Surgical data science: the new knowledge domain
Authors: Vedula S. Swaroop , Hager Gregory D. 
Published: April 2017

Abstract
Healthcare in general, and surgery/interventional care in particular, is evolving through rapid advances in technology and increasing complexity of care, with the goal of maximizing the quality and value of care. Whereas innovations in diagnostic and therapeutic technologies have driven past improvements in the quality of surgical care, future transformation in care will be enabled by data. Conventional methodologies, such as registry studies, are limited in their scope for discovery and research, extent and complexity of data, breadth of analytical techniques, and translation or integration of research findings into patient care. We foresee the emergence of surgical/interventional data science (SDS) as a key element to addressing these limitations and creating a sustainable path toward evidence-based improvement of interventional healthcare pathways. SDS will create tools to measure, model, and quantify the pathways or processes within the context of patient health states or outcomes and use information gained to inform healthcare decisions, guidelines, best practices, policy, and training, thereby improving the safety and quality of healthcare and its value. Data are pervasive throughout the surgical care pathway; thus, SDS can impact various aspects of care, including prevention, diagnosis, intervention, or postoperative recovery. The existing literature already provides preliminary results, suggesting how a data science approach to surgical decision-making could more accurately predict severe complications using complex data from preoperative, intraoperative, and postoperative contexts, how it could support intraoperative decision-making using both existing knowledge and continuous data streams throughout the surgical care pathway, and how it could enable effective collaboration between human care providers and intelligent technologies. In addition, SDS is poised to play a central role in surgical education, for example, through objective assessments, automated virtual coaching, and robot-assisted active learning of surgical skill. However, the potential for transforming surgical care and training through SDS may only be realized through a cultural shift that not only institutionalizes technology to seamlessly capture data but also assimilates individuals with expertise in data science into clinical research teams. Furthermore, collaboration with industry partners from the inception of the discovery process promotes optimal design of data products as well as their efficient translation and commercialization. As surgery continues to evolve through advances in technology that enhance delivery of care, SDS represents a new knowledge domain to engineer surgical care of the future.
The subjectivity of older adults in the late works of eminent creators
Authors: Straś-Romanowska Maria M. 
Published: April 2017

Abstract
This article shows - in the light of personalistic psychology - the subjective features of old people which are manifested in the works of eminent creators. The progress of inner subjectivity is shown as a specific developmental tendency. It is characterized by reflection, concentration on one’s own experiences, remembrances and encapsulating life events. It is readily observable that old creators are open to spiritual values and that melancholy is a predominant mood in their creation.
Can Transcranial Direct Current Stimulation Improve Muscle Power in Individuals With Advanced Weight-Training Experience?
Authors: Lattari Eduardo , Campos Carlos , Lamego Murilo Khede , Legey Sandro , Neto Geraldo Maranhão , Rocha Nuno Barbosa , Oliveira Aldair José , Carpenter Carlos Sandro , Machado Sérgio 
Published: April 2017

Abstract
Lattari, E, Campos, C, Lamego, MK, Legey, S, Neto, GM, Rocha, NB, Oliveira, AJ, Carpenter, CS, and Machado, S. Can transcranial direct current stimulation improve muscle power in individuals with advanced weight-training experience? J Strength Cond Res 34(1): 97–103, 2020—The aim of this study was to investigate the effects of transcranial direct current stimulation (tDCS) on countermovement jump (CMJ) performance in men with advanced strength-training experience. Ten healthy male subjects with advanced strength training and squatting exercise experience were included. Participants took part in an initial visit to the laboratory to complete anthropometric measurements and CMJ kinematic test-retest reliability. Participants then completed 3 experimental conditions, 48–72 hours apart, in a randomized, double-blinded crossover design: anodal, cathodal, and sham-tDCS (2 mA for 20 minutes targeting the motor cortex bilaterally). Participants completed 3 CMJ tests before and after each experimental condition, with 1-minute recovery interval between each test. The best CMJ in each moment was selected for analysis. Two-way (condition by moment) repeated measures analysis of variance was performed for CMJ height, flight time (FT), and muscular peak power (PP). Effect sizes and interindividual variability of tDCS responses were also analyzed. There was a significant condition by moment interaction for all outcome measures, with a large prepost increase in CMJ height, FT, and PP in the anodal condition. All the participants displayed CMJ performance improvements after the anodal condition. There were no significant differences in both cathodal and sham conditions. Anodal tDCS may be a valuable tool to enhance muscle power–related tasks performance, which is extremely relevant for sports that require vertical jumping ability. Anodal tDCS may also be used to support strength training, enhancing its effects on performance-oriented outcome measures.