bluuebunny/crossref_metadata_2025_split huggingface dataset:
The safety and efficacy of N-acetylcysteine as an augmentation in the treatment of obsessive-compulsive disorder in adults: a systematic review and meta-analysis of randomized clinical trials
Authors: Eghdami Shayan , Eissazade Negin , Heidari Mokarar Mohsen , Boroon Mahsa , Orsolini Laura , Shalbafan Mohammadreza 
Published: September 2024

BackgroundObsessive-compulsive disorder (OCD) ranks as the fourth most prevalent psychiatric disorder, with selective serotonin reuptake inhibitors (SSRIs) as its mainstay pharmacological treatment. However, approximately 40 to 60% of patients do not adequately respond to initial treatment, highlighting the need for alternative options. N-acetylcysteine (NAC) is one of the several medications that have been used in augmentation with SSRIs to enhance their efficacy.ObjectivesWe aimed to investigate the safety and efficacy of NAC, a glutamate-modulating agent, as an augmentation in the treatment of moderate to severe OCD.MethodWe conducted a thorough search across PubMed, Scopus, Web of science, and ProQuest to identify relevant trials published until December 2023. The primary outcome of interest was the mean difference between the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores before and after administrating augmented NAC among patients with moderate to severe OCD. Furthermore, we compared the occurrence of adverse drug events between the experimental and control groups.ResultsWe included six randomized controlled trials with 195 patients. The results of our study indicated a positive outcome for the experimental group in terms of the total Y-BOCS score when using the medication for a period of five to eight weeks (p-Value = 0.05). However, no significant difference was observed for durations shorter than five weeks or longer than 12 weeks. Additionally, no significant difference was found between the two groups in terms of the obsession and compulsion Y-BOCS scores. Furthermore, no significant differences were observed in terms of adverse events.ConclusionAugmentation of NAC with SSRIs may benefit patients with moderate to severe OCD. However, it is necessary to conduct additional multi-center trials over extended periods to develop a comprehensive strategy for action.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023463683.
Women coaches leadership development programme: an evaluation study of programme effectiveness
Authors: Jowett Sophia , Slade Katelynn , Gosai Jyoti , Davis Louise 
Published: September 2024

IntroductionWomen's sport has been experiencing continuous growth, yet the low levels of women coaches in the United Kingdom (UK) suggests that the sport is missing out on potential talent. Guided by empirical research, a women-only leadership development programme was designed and implemented by UK Sport to a cohort of 20 coaches from January to June 2021. The main characteristics of the programme included raising awareness of gender bias while at the same time focusing on women coaches' leadership purpose and skills within a safe environment that supports coaches to build their leader identity.MethodsKirkpatrick's (1998) four-level model was employed to guide the evaluation of programme effectiveness: reactions, learnings, applications and results. Interviews were conducted with 17 participating coaches.ResultsContent analysis of the qualitative data revealed five general categories (a) evaluations were mainly positive highlighting the aspects of the programme they liked, enjoyed and made most impression onto them; (b) learnings that impacted their work directly and immediately emerged as was the importance of on-going development; and (c) the majority of the women desired progression and transitioning to senior coach leadership positions was felt within their grasp; nonetheless, (d) challenges emerged and were described as organisational (e.g., recruitment, remuneration) and personal (e.g., work-life balance, childcare).DiscussionOverall, the effectiveness of the programme was captured in its capacity to raise awareness, develop knowledge, build connections, and inspire so much so that its effects translated to many of these women moving to more senior leadership positions post-programme. Practically, this evaluation highlights that investment in individual coaches is part of the systemic change required to bring about gender balance in the coach workforce.
Effects of a 12-week training program in outdoor gym equipment in morphological and functional parameters, quality of life, and physical activity levels in older adults
Authors: Barbosa Welmo A. , Machado Alexandre F. , Bergamin Marco , Gobbo Stefano , Bullo Valentina , Pontes Junior Francisco Luciano , Evangelista Alexandre L. , Scartoni Fabiana R. , Rica Roberta L. , Bocalini Danilo S. 
Published: September 2024

IntroductionThis study aimed to investigate the effectiveness of a supervised physical training program with controlled cadence on functional fitness parameters, quality of life perception, and physical activity level in older adults.MethodsSixty physically independent older adults were randomly divided into three groups: Supervised Training (ST,n = 20), Unsupervised Training (UT,n = 20), and a Control Group (C,n = 20). The ST and UT groups participated in a 12-week program, performing exercises three times a week for 30 min. The ST group had structured weekly sessions consisting of a 5-minute warm-up (walking at 60% of max heart rate), 20 sets of 30 s at a moderate pace controlled by a metronome with 30 s of passive recovery, and a 5-minute cool-down on non-consecutive days. The UT group trained spontaneously using senior gym equipment, including elliptical machines, rowing machines, air skiers, and leg press machines. The control group maintained their usual daily routines throughout the study. Parameters evaluated included body mass, body mass index (BMI), muscle thickness (biceps brachii, triceps brachii, and vastus lateralis), and functional capacity tests (walking 10 m [W10 m], rising from a sitting position [RSP], rising from the prone position [RVDP], sitting and rising from a chair and moving around the house [SRCW]). Quality of life was assessed across physical, psychological, environmental, and social domains, and physical activity levels were also measured.ResultsNo significant changes (p &gt; 0.05) in body mass, BMI, or muscle thickness were observed between groups before and after the intervention. However, significant time effects in functional fitness tests were found only in the ST group for W10 m (p = 0.0469), RVDP (p &lt; 0.0004), RSP (p &lt; 0.0001), and SRCW (p &lt; 0.0001). Quality of life improved significantly over time in the ST and UT groups across all domains (p &lt; 0.0001). Both ST and UT groups also showed significant increases in weekly physical activity time (p &gt; 0.0001).Conclusion12 weeks of training improved quality of life perception and physical activity levels in older adults.
Coumarins with Different Substituents from Leonurus japonicus Have Opposite Effects on Uterine Smooth Muscle
Authors: Fan Yunqiu , Liu Chenhao , Wang Fang , Li Lei , Guo Yuqin , Zhou Qinmei , Xiong Liang 
Published: September 2024

Leonurus japonicus Houtt is an exceptional medicinal herb used to treat obstetrical and gynecological diseases in traditional Chinese medicine, and it has significant effects on the treatment of dysmenorrhea and postpartum hemorrhage. This study investigated the effects of coumarins with diverse substituent groups from L. japonicus on isolated uterine smooth muscle and the preliminary mechanism of the most effective compound. Eight coumarins isolated from L. japonicus were assessed for their effects on the isolated uterine smooth muscle of nonpregnant rats in vitro. Coumarins 1 and 2 significantly promoted the contraction of rat uterine smooth muscle strips, whereas coumarins 3–5 showed remarkable relaxing effects against oxytocin (OT)-induced rat uterine smooth muscle contraction. Further mechanism investigations revealed that bergapten (coumarin 1) significantly increased the level of Ca2+ in uterine tissues by promoting extracellular Ca2+ influx and intracellular Ca2+ release, which were related to the activation of L-type Ca2+ channels and α-receptors. By contrast, osthole (coumarin 5), an α receptor antagonist, inhibited OT-induced uterine smooth muscle contraction by decreasing the level of Ca2+ in uterine tissues via inhibition of extracellular Ca2+ influx and intracellular Ca2+ release. This study demonstrates that the coumarins from L. japonicus are effective substances for regulating uterine smooth muscle contraction, but different coumarins with diverse substituent groups have different, even opposite effects. It can be inferred that coumarins are closely related to the efficacy of L. japonicus in the treatment of dysmenorrhea and postpartum hemorrhage.
The Anti-Vitiligo Effects of Feshurin In Vitro from Ferula samarcandica and the Mechanism of Action
Authors: Nueraihemaiti Mayire , Deng Zang , Kamoldinov Khamidulla , Chao Niu , Habasi Maidina , Aisa Haji Akber 
Published: September 2024

Background: Vitiligo is a complex disorder characterized by skin depigmentation; the canonical Wnt signaling pathway that involves β-catenin plays a crucial role in promoting the melanin production in melanocytes. Targeted inhibition of the Janus kinase JAK-STAT pathway can effectively diminish the secretion of the chemokine C-X-C motif ligand CXCL10, thereby safeguarding melanocytes. Ferula has been applied as a treatment regimen for a long period; however, its use for the treatment of vitiligo has not been previously documented. Methods: CCK-8 assay, Intracellular melanin content assay, Tyrosinase activity assay, Western blotting, qRT-PCR, and ELISA methods were employed. Using molecular docking verified the inhibitory effects of feshurin on the JAK1. Results: The sesquiterpene coumarin feshurin was separated from Ferula samarcandica. Feshurin was shown to induce GSK-3β phosphorylation, resulting in the translocation of β-catenin into the nucleus. This translocation subsequently upregulated the transcription of microphthalmia-associated transcription factor (MITF), leading to increased tyrosinase activity and melanin production. In addition, feshurin inhibited the production of chemokine CXCL10 via the JAK-STAT signaling pathway, which was verified by molecular docking. Conclusions: Based on these findings, it can be concluded that feshurin exhibits significant potential for the development of novel anti-vitiligo therapeutics.
Effects of Acmella radicans Invasion on Soil Seed Bank Community Characteristics in Different Habitats
Authors: Wu Xiaohan , Yang Kexin , Zheng Fengping , Xu Gaofeng , Fan Zewen , Clements David Roy , Yang Yunhai , Yang Shaosong , Jin Guimei , Zhang Fudou , Shen Shicai 
Published: September 2024

To examine the effects of the recent Acmella radicans invasion on plant community and diversity in invaded habitats, the composition, density, species richness, diversity indices, and evenness index of the soil seed bank community of two different habitats (wasteland and cultivated land) in Yunnan Province, China, were analyzed through field sampling and greenhouse germination tests. A total of 28 species of plants belonging to 15 families and 28 genera, all annual herbs, were found in the soil seed bank. Seed densities and species number in the seed bank tended to be greater in April than in October; cultivated land also featured higher seed densities and species numbers compared to wasteland. With increased A. radicans cover, the seed bank population of A. radicans also significantly increased, but the seed bank populations of many other dominant species (e.g., Ageratum conyzoides and Gamochaeta pensylvanica) and native species (e.g., Laggera crispata and Poa annua) clearly declined. The germination of A. radicans seeds was concentrated during the period from the 4th to the 5th weeks. Vertically, the seed number of A. radicans was significantly different among the 0–5 cm, 5–10 cm and 10–20 cm layers that accounted for 80.7–90.6%, 9.4–16.1% and 0.0–3.2% of the total seed density in wasteland, respectively; and in cultivated land, A. radicans accounted for 56.8–64.9%, 26.7–31.8% and 8.1–13.5% of the total seed density, respectively. With reduced A. radicans cover, the species richness, Simpson index, Shannon–Wiener index, and Pielou indices of the weed community generally increased, and most diversity indices of weed communities in cultivated land were lower than in wasteland under the same cover of A. radicans. The results indicate that the invasion of A. radicans has negatively affected local weed community composition and reduced weed community diversity, and that these negative impacts in cultivated land may be enhanced by human disturbance. Our study was the first to elucidate the influence of A. radicans invasion on soil seed bank community characteristics in invaded habitats, providing a better understanding of its invasion and spread mechanisms in order to aid in developing a scientific basis for the prevention and control of this invader.
Evaluation of utilization and consequences of CRP point-of-care-testing in primary care practices: qualitative interviews with general practitioners from Germany
Authors: Jung Paul , Bleidorn Jutta , Doepfmer Susanne , Heintze Christoph , Krause Markus , Kuempel Lisa , Kuschick Doreen , Lehmann Lena-Sophie , Rost Liliana , Toutaoui Kahina J , Wolf Florian 
Published: September 2024

BackgroundThe use and advantages of point-of-care tests (POCTs) for C-reactive protein (CRP) in general practice, especially for upper respiratory tract infections (uRTIs), have been studied extensively. However, there is limited knowledge about test indications, prerequisites, and integration of these tests into everyday practice.AimThis study aims to investigate the attitudes and experiences of general practitioners (GPs) in Germany regarding the use of semi-quantitative CRP-POCTs. The study places special emphasis on implementation in routine care, including testing procedures, feasibility, opportunities and barriers for specific consultation scenarios, as well as test indications and their impact on GP-patient communication.Design & settingQualitative interview study with 10 GPs (May/2023 to Aug/2023)MethodTen German GPs who participated in an observational study on CRP-POCT use in general practices were interviewed using semi-structured interviews. Audio recordings were transcribed and content analysis was performed.ResultsInterviewed GPs stated that CRP-POCTs offer several advantages for various treatment cases. They improve diagnostic confidence and certainty of GPs’ therapeutic decisions, and offer a broad spectrum of indications and application scenarios. Additionally, they have a positive impact on GP-patient communication, and their ease of use enables rapid implementation into existing workflows. On the other hand, CRP-POCT increase the time required for test performance and patient consultation.ConclusionDue to the numerous benefits of semi-quantitative CRP-POCTs, interviewed GPs have a favourable attitude towards their regular integration into everyday practice. Implementation barriers include increased time and personnel expenses for testing and inadequate reimbursement by German statutory health insurance.
HUMMINGBIRD STRUCTURE OF SOUTHEAST SASKATCHEWAN
Authors: Smith David G. , Pullen Jack R. 
Published: September 2024

ABSTRACT
Saskatchewan’s first Devonian oil pool was discovered September, 1966 at Hummingbird, 45 mi southwest of Weyburn, Saskatchewan. The Hummingbird structure, located on the northwest flank of the Williston basin, is domal in nature and covers approximately 1 sq mi. Oil production is from two zones. The Ratcliffe Member of the Mississippian Charles Formation produces from an average of 49 ft in an algal and bioclastic limestone. The Devonian Birdbear Formation produces from an average of 56 ft in a fine-crystalline, vuggy dolomite.
The Hummingbird structure is not diastrophic in nature. Rather, it is a sedimentary structure resulting from multiple-stage salt solution and collapse. Recurring local solution of Middle Devonian Prairie Evaporite salt during Late Devonian and Early Mississippian time resulted in collapse of overlying strata and deposition of compensating thicknesses of Souris River, Duperow and Bakken sediments. Between Mississippian and Cretaceous time, solution of Prairie Evaporite salt in the surrounding area caused collapse of all post-Prairie Evaporite beds. The extra Souris River, Duperow and Bakken strata at Hummingbird created the structure. Vertical migration of formation waters along a high-angle fault is suggested as the cause of the local salt solution at Hummingbird.
Debris Index before and after gargling with moringa leaves
Authors: Putri Zahra Aulia , Lestari Syifa Yulia , Ngatemi Ngatemi 
Published: September 2024

Background: Dental and oral hygiene is one of the factors that trigger dental caries. Preventive efforts can be made to anticipate oral health problems, one of which is gargling. The chemical mouthwash ingredient that is often used is chlorhexidin, while if used for a long time it can cause side effects in the form of bacterial resistance and discomfort. Therefore, the need for natural ingredients to minimize side effects that can arise cheap, safe and effective natural ingredients for gargling, one of which is moringa leaves. Objective: The purpose of this study was to determine the debris index before and after gargling with moringa reduce water in TPQ Al-Barokah Bojonggede students in 2024. Methods: This research method is quasi experiment research. This study was conducted with a sample of 30 students obtained using purposive sampling technique. The instrument used was the debris index examination sheet. Results: The difference of the debris index score before and after gargling with moringa reduce water is 0.43. With an average debris index score before gargling is 1,56 and the average debris index score after gargling is 1,13. Conclusion: It can be concluded that after gargling with moringa reduce water can reduce the debris index score.
Faktor-Faktor yang Berhubungan dengan Pengetahuan Wanita Usia Subur tentang Pemeriksaan Inspeksi Visual Asam Asetat (IVA)
Authors: Farlikhatun Lili , Idealistiana Lia 
Published: September 2024

Kanker serviks merupakan jenis penyakit kanker yang paling banyak diderita wanita. Kanker serviks ini menduduki urutan nomor dua penyakit kanker di dunia, bahkan sekitar 500.000 wanita diseluruh dunia didiagnosa menderita kanker serviks dan rata-rata 270.000 meninggal setiap tahun dan Insidensi dilaporkan lebih tinggi terjadi di negara berkembang dari pada di negara maju. Dari data Badan Kesehatan Dunia diketahui terdapat 493.243 jiwa pertahun penderita kanker serviks baru di dunia dengan angka kematian sebanyak 273.505 jiwa pertahun. Untuk mengetahui Faktor-faktor yang berhubungan dengan pengetahuan wanita usia subur tentang pemeriksaan inspeksi visual asam asetat (IVA) di Puskesmas Pondok Gede Tahun 2018. Penelitian yang dilakukan adalah metode analitik dengann rancangan cross sectional yang artinya variabel dependen dan independen, diukur secara bersamaan dalam waktu yang sama. variable yang berhubungan dengan pengetahuan wanita usia subur tentang pemerikksaan IVA adalah umur (P value: 0,004), pendidikan (P value: 0,001), pekerjaan (P value: 0,001), sumber informasi ( P value: 0,003).
Hubungan antara Status Gizi Ibu dengan Kejadian BBLR pada Kehamilan Aterm Di RSUD Kabupaten Bekasi Tahun 2018
Authors: Tridiyawati Feva , Mariyani  
Published: September 2024

Angka kejadian BBLR di Indonesia adalah sekitar 11,1 persen pada tahun 2011. Tahun 2013 angka BBLR di Indonesia memang sedikit menurun, yaitu mencapai 10,2 persen, dengan prevalensi tertinggi ditempati oleh Propinsi Nusa Tenggara Timur (19,2 persen) dan terendah di Propinsi Sumatra Barat (6 persen) (UNICEF, 2011; Riskesdas, 2013). Menurut data Laporan Program Kesehatan Anak Provinsi Jawa Barat Tahun 2010 – 2012, jumlah kematian neonatus yang dilaporkan di Jawa Barat mencapai angka 3.624 dan kematian bayi mencapai 4.650. Untuk Untuk mengetahui hubungan antara status gizi ibu dengan kejadian Bayi Berat Lahir Rendah pada kehamilan aterm di RSUD Kabupaten Bekasi Periode Januari-Maret tahun 2018. Metode penelitian yang digunakan adalah analitik deskriptif, Populasi dalam penelitian ini adalah seluruh ibu yang bersalin di RSUD Kabupaten Bekasi Periode Januari-Maret 2016 dengan jumlah sampel sebanyak 53 orang. Berdasarkan dari hasil penelitian didapatkan hasil terbanyak pada status gizi ibu kurang yaitu sebanyak 37 orang (69,8%) dan didapatkan hasil terendah pada status gizi ibu normal yaitu sebanyak 16 orang (30,2%).
The Influence Of Consumer Ethnocentrism, Attitudes And Consumer Intentions On Actual Purchasing Behavior On Instant Noodle Products
Authors: Fatrisia Mixilia Embun , Witjaksono Beny , Yudistria Yuyus , Baskara Ika 
Published: September 2024

Consumer ethnocentrism is very important because it affects consumer purchasing decisions. This study aims to reveal how demographic factors such as age, gender, education, and income affect consumers' views on domestically made instant noodles and foreign-made instant noodles which affect attitudes, intentions, and purchasing behavior. This study uses a purposive sampling method involving 200 consumers who consume domestically made instant noodle products and foreign-made instant noodle products in the JABODETABEK area. The results of primary data analysis were carried out using the Structural Equation Modeling (SEM) method. The sample criteria are consumers who consume domestically made instant noodle products and instant noodle products made abroad at least 2 times. The results showed that consumer demographics affect consumer ethnocentrism, consumer ethnocentrism affects consumer attitudes, consumer attitudes affect consumer intentions, consumer ethnocentrism has no effect on consumer intentions, consumer intentions affect actual purchasing behavior. This study contributes that age, income and ethnocentrism significantly influence consumer attitudes and intentions towards local products and it is recommended that the sample be expanded and additional factors that may influence the relationship between ethnocentrism, consumer attitudes and purchase intentions be taken into account. Further research could also examine the long-term impact of ethnocentrism on actual purchase behavior as well as other factors that could potentially influence consumer decisions in greater depth.
Keywords: Consumer demographics, Consumer ethnocentrism, Attitudes, Consumer intentions and Actual purchase behavior