bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyrene Based Schiff Base for Cascade Fluorescent “On‐Off” Detection of Aluminium(III) and Fluoride Ions and its Applications in Live Cells Imaging
Authors: Bhardwaj Kanishk , Yadav Rashmi , Samanta Animesh , Jangir Ritambhara , Jali Bigyan Ranjan , Kumar SK Ashok , Sahoo Suban K. 
Published: October 2024

AbstractAn easy‐to‐prepare pyrene‐based Schiff base PNZ was synthesized by condensing equimolar amount of 1‐pyrenebutyric hydrazide with 2‐hydroxy‐naphthaldehyde, and employed as a fluorescent chemosensor for in‐situ cascade detection of aluminium (Al3+) and fluoride (F−) ions. In DMSO:H2O (1 : 1, v/v), the weakly emissive PNZ showed a significant fluorescence enhancement at 455 nm selectively upon the addition of Al3+ due to the complexation‐induced formation of a pyrene excimer. Schiff base PNZ and Al3+ formed a complex in 2 : 1 binding ratio with the estimated binding constants of K1:1=9826.01 M−1 and K2:1=3188.49 M−1. The sensing mechanism was explored by performing quantum mechanical calculations and 1H‐NMR titration of PNZ with Al3+. The in‐situ formed PNZ‐Al3+ complex species enabled the fluorescent turn‐off detection of F−. Using PNZ and PNZ‐Al3+, the concentrations of Al3+ and F− ions can be detected down to 2.89×10−7 M and 1.88×10−7 M, respectively. The cytotoxicity of the PNZ and its ability to bioimage Al3+ and F− ions was examined in the human cervical cancer cell line. Finally, the receptor PNZ was applied for the quantification of Al3+ and F− ions in various real samples, such as tap water, river water, rainwater, mouthwash, and toothpaste.
Design, Synthesis and Biological Activities Evaluation of Novel Pterostilbene‐Urea Derivatives as Potential Anti‐Inflammatory Agents
Authors: Wang Shouchuan , Huang Shaoling , Peng Feng , Wu Yanchun , Pan Weigao , Huang Yunhou , Luo Peng 
Published: October 2024

Abstract1. The toxicity of derivatives was removed by the reasonable modification of bioactive skeleton. 2. As potential COX‐2 inhibitor with IC50 values ranging from 39.42 to 179.84 nM/L, compounds (Q4‐Q10, Q20) exhibited superior anti‐inflammatory activity at low micromolar concentrations. 3. Q7 (IC50 (COX‐2)= 61.05 nM/L), Q10 (IC50 (COX‐2)= 54.68 nM/L) and Q20 (IC50 (COX‐2)= 39.42 nM/L) showed stronger COX‐2 inhibitory abilities than Celecoxib (IC50 (COX‐2)= 67.89 nM/L). 4. The strongest anti‐inflammatory agent, Q20 (IC50 NO= 9.96 μM/L, IC50 (COX‐2)= 39.42 nM/L) effectively inhibited the secretion of IL‐1β and TNF‐α, exhibited the IC50 values of 12.30 and 9.07 μM/L respectively. 5. Q20 exerted as anti‐inflammatory actives via targeting COX‐2, down‐regulating iNOS and TLR4 protein, and inhibiting the activation of NLRP3 inflammasome and NF‐κB signal pathway.
PLGA‐Loaded Nedaplatin (PLGA‐NDP) Inhibits 7,12‐Dimethylbenz[a]anthracene (DMBA) Induced Oral Carcinogenesis via Modulating Notch Signaling Pathway and Induces Apoptosis in Experimental Hamster Model
Authors: Ilanchit Chenni Senkuttuvan , Suresh Kathiresan , Theerthu Azhamuthu , Ahamed Abulkalam A. N. , Pugazhendhi Ravichandran , Vasu Rajeswari 
Published: October 2024

ABSTRACTThe present study is designed to evaluate the nanotherapeutic efficacy of prepared PLGA‐loaded Nedaplatin (PLGA‐NDP) against 7,12‐dimethyl benz(a)anthracene (DMBA)‐induced experimental oral carcinogenesis in hamster buccal pouch (HBP) model. The buccal pouch of golden Syrian hamsters was painted with 0.5% DMBA in liquid paraffin three times a week for 14 weeks, ultimately leading to the development of oral squamous cell carcinoma (OSCC). Oral administration of PLGA‐NDP (preinitiation) and Cisplatin delivery (5 mg/kg b.wt) started 1 week before the carcinogen exposure and continued on alternative days. Post‐administration of PLGA‐NDP (5 mg/kg b.wt) started 2 days after carcinogen (DMBA) induction until the end of the experiment. After the 14th week, we observed that DMBA‐painted hamsters exhibited tumor formation, morphological alterations, and well‐differentiated OSSC in addition to the responsive molecular proteins during oral carcinogenesis. Furthermore, immunoblotting analysis demonstrated that PLGA‐NDP inhibits Notch signaling, as evidenced by downregulation of Bcl‐Xl, Bcl‐2, p21, PGE2, HGF, and CXCL12 proteins, and upregulation of p53 and Bax. This apoptotic response is crucial for PLGA‐NDP to induce apoptosis. In addition, RT‐PCR results showed that PLGA‐NDP nanoparticles play a downregulatory role in the therapeutic action of the notch signaling gene (Notch1, Notch 2, Hes1, Hey1, and Jagged1) at the mRNA transcription level in HBP carcinoma. Taken together, these data indicate that PLGA‐NDP is a potent inhibitor of oral carcinogenesis and the expansion of cells that specifically target the Notch signaling pathway indicates that obstructing Notch signaling could potentially serve as a new and innovative therapeutic approach for oral squamous cell carcinoma (OSCC).
Molecular Architecture @ MOFs: Designing a Multifunctional Catalyst for the Cascade Reaction of Olefins via Epoxides to Cyclic Carbonates
Authors: Hemmer Karina , Hegelmann Markus , Fischer Roland A. , Cokoja Mirza 
Published: October 2024

AbstractEmploying enzymatic reaction cascade principles to synthesize artificial materials with multiple autonomously operating active sites is one of the holy grails in modern catalysis research. In this regard, metal–organic frameworks (MOFs) are promising host platforms. Yet, applying MOFs as enzyme‐mimicking catalysts is synthetically challenging. Herein, we present a design strategy for the synthesis of porphyrin‐based MOFs for the cascade catalysis of the conversion of olefins to epoxides and their cycloaddition with CO2 to cyclic carbonates. The MOFs feature tunable dual active sites with synthetically controllable metal variations. A clear dependence of the metal combination on the catalytic performance of the MOF catalysts is shown. This work advances the understanding essential for designing sophisticated, multifunctional porphyrin MOFs for efficient one‐pot cascade catalysis.
Trace Amount of Ir Decorated NiFe Phosphide In‐Situ Grown on Carbon Cloth as Cost‐Effective Electrocatalyst for Oxygen Evolution Reaction
Authors: Chen Xue , Xia Jiawei , Tong Yuxuan , Zhou Miaoen , He Yuming , Wang Kun , He Guangyu , Chen Haiqun 
Published: October 2024

AbstractCost‐effective electrocatalysts is a key constituent to establish the balance of cost and catalytic efficiency for oxygen evolution reaction (OER) via water electrolysis in the area of energy conversion and storage. NiFe phosphide decorated with trace amount of iridium (Ir) species in‐situ grown on carbon cloth was prepared by a facile wet chemistry approach followed by a phosphorization post‐treatment at a relative low temperature. The optimal electrocatalyst, Ir2‐NiFePx/CC, exhibits excellent OER activity, with an low overpotential of 190 mV at 10 mA cm−2 for alkaline OER, and a desirable long‐term durability over 90 h. The outstanding OER performance stems from the structural evolution via phosphorization process, Ir decoration with more high‐valence stated Ir4+ species, and tight connection between individual components of the electrode, which gives rise to the strong activity to the active sites and faster reaction kinetics in the alkaline OER process. Mover, the Ir loading was as low as approximately ~1.7 wt % (0.29 mg cm−2), showing promissing propective in cost‐effective OER.
Unlocking the Chemical and Structural Complexity of Aluminum Hydroxy Acetates: from Commodity Chemicals to Porous Materials
Authors: Achenbach Bastian , Liedtke Lena‐Marie , Näther Christian , Svensson Grape Erik , Ken Inge A. , Stock Norbert 
Published: October 2024

AbstractAluminum acetates have been in use for more than a century, but despite their widespread commercial applications, essential scientific knowledge of their synthesis‐structure‐property relationships is lacking. High‐throughput screening, followed by fine tuning and extensive optimization of reaction conditions using Al3+, OH− and CH3COO− ions, has unraveled their complex synthetic chemistry, yielding for the first time the four phase pure products Al(OH)(O2CCH3)2 ⋅ x H2O (x=0, 2) (1A and CAU‐65, 1B), Al3O(HO2CCH3)(O2CCH3)7 (2), and the porous aluminum salt [Al24(OH)56(CH3COO)12](OH)4 (CAU‐55‐OH, 3). Structure determination by electron and X‐ray diffraction was carried out and the data suggested porosity for 1B and 3, which was confirmed by physisorption experiments. Even the scale‐up to the 10 L scale was accomplished for 1A, 1B and 3 with yields of up to 1.1 kg (99 %). This study of a seemingly simple chemical system provides important information on both fundamental inorganic chemistry and porous materials.
Chiral Self‐Sorting Process With C2 Symmetric Bisimidazoline Ligands
Authors: Dussart Caitlyn , Maisse‐François Aline , Bellemin‐Laponnaz Stéphane 
Published: October 2024

ABSTRACTWe have studied the coordination chemistry of chiral imidazoline‐based C2‐symmetric ligands with zinc (II) and copper (II). Two types of bisimidazoline ligands were studied, one with the free amine (BIM‐H) and the other with the amine protected by a toluene sulfonyl group in position 6 (BIM‐Ts). The complexes formed were isolated, purified, and characterized, in particular by X‐ray diffraction studies and CD in the case of the enantiopure complexes. By playing with the choice of ligand system (enantiopure or racemate), we were able to show that the selective formation of homoleptic and heteroleptic metal complexes can be controlled by means of the chiral molecular instruction of bisimidazoline ligands.
Myosin VI Is Associated With the Endoplasmic Reticulum in Regions of Sertoli Cells Containing Tubulobulbar Complexes
Authors: Tretjakov Samuel , Palia Prunveer , Vogl A. Wayne 
Published: October 2024

ABSTRACTMyosin VI has been reported by others to localize in association with various regions of apical tubulobulbar complexes (TBCs) at sites of attachment between Sertoli cells and late spermatids in the mouse. Tubulobulbar complexes internalize “intact” intercellular junctions during sperm release and during spermatocyte translocation through the blood‐testis barrier. Here, we use super‐resolution (STED—stimulated emission depletion) and electron microscopy of immunolabeled sections of rat testis to clearly define the localization of anti‐myosin VI reactivity both at apical and basal sites in the epithelium. In data stacks collected by STED imaging, staining at TBCs was predominantly associated with bulb regions of the complexes. At apical sites, when data stacks were analyzed with an Imaris software, staining appeared around and extended between adjacent bulbs. At basal sites, in addition to labeling at TBC bulbs, reactive sites appeared concentrated in regions close to but not directly associated with intercellular junctions. At the ultrastructural level, labeling was predominantly associated with cisternae of the endoplasmic reticulum associated with the bulbs of TBCs and near to basal junction complexes. We conclude that myosin VI may be associated with specific subdomains of the endoplasmic reticulum related to TBC bulbs and associated basal junction complexes between Sertoli cells.
Carfilzomib‐Induced Thrombotic Microangiopathy—Two Case Reports
Authors: Attucci Irene , Pilerci Sofia , Messeri Maria , Pengue Ludovica , Tomasino Giulia , Caroti Leonardo , Vannucchi Alessandro M. , Antonioli Elisabetta 
Published: October 2024

ABSTRACTBackgroundThrombotic microangiopathy (TMA) is a pathological syndrome characterized by a combination of three key features: microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and organ damage, primarily affecting the kidneys. There are several drugs known to have a definite or probable causal association with TMA, and carfilzomib, a second‐generation irreversible proteasome inhibitor (PI), approved for the treatment of multiple myeloma (MM), is one of them. In the medical literature, there have been a growing number of reports describing this serious adverse event occurring in MM patients. The precise mechanisms underlying the development of PI‐induced TMA are not yet fully understood. Significant improvements in both renal and hematological aspects have been documented following the administration of eculizumab.Recent FindingsIn this report, we present two cases of MM patients who developed TMA while undergoing carfilzomib therapy. These cases were successfully treated at the Haematology Unit, Careggi Hospital in Florence. In our cases as well, the introduction of eculizumab resulted in rapid enhancements in renal function and platelet count, ultimately leading to the discontinuation of hemodialysis after 4 and 2 weeks, respectively.Discussion and ConclusionWe assessed 91 patients who received carfilzomib‐based therapies at our Haematology Department, during which we identified two cases of DITMA (2.2% incidence). Additionally, we conducted a literature review and discovered a total of 75 documented cases of carfilzomib‐induced TMA. Our experience aligns with the cases reported in literature: this adverse event can manifest at any point during treatment, regardless of the specific drug combinations used alongside carfilzomib. The initial and most crucial step in its management involves discontinuing carfilzomib therapy; therefore, recognizing TMA in a timely manner is of utmost importance. Eculizumab could play a role in improving and expediting the resolution of this potentially fatal adverse event, but further studies are needed.In a MM patient receiving carfilzomib, presenting with anemia, thrombocytopenia, and impaired renal function, a carfilzomib‐induced TMA should be suspected in order to discontinue the causative agent.
Preparation and Catalytic Properties of Gold Single‐Atom and Cluster Catalysts Utilizing Nanoparticulate Mg‐Al Layered Double Hydroxides
Authors: Nakayama Akihiro , Yoshida Ayano , Aono Chika , Honma Tetsuo , Sakaguchi Norihito , Taketoshi Ayako , Fujita Takashi , Murayama Toru , Shimada Tetsuya , Takagi Shinsuke , Ishida Tamao 
Published: October 2024

AbstractAu single atoms and clusters were stabilized on Mg−Al layered double hydroxide nanoparticles (LDH NPs), and the obtained Au@LDH NPs were supported on SiO2 and CeO2. After hydrogen reduction, Au single atoms were found together with Au clusters on LDH/SiO2. In contrast to Au single‐atom catalysts which are deposited in metal vacancies of oxide supports, the LDH NPs stabilize very small Au species despite the absence of metal vacancies. The obtained Au(0)@LDH/SiO2 catalyzed aerobic oxidation of alcohols, and Au single atoms maintained after the reaction. Given that only Au NPs were observed on bulk LDH, the abundant surface OH group of LDH NPs would contribute to stabilize Au, resulting in higher activity than Au/LDH‐bulk. After calcination to transform LDH to mixed metal oxide (MMO), the obtained Au(0)@MMO/SiO2 also exhibited high catalytic activity. Moreover, Au(0)@LDH/CeO2 exhibited higher activity and excellent selectivity for hydrogenation of 4‐nitrostyrene to 4‐aminostyrene than conventional Au catalysts such as Au/CeO2 and Au/TiO2. We demonstrated that Au size can be minimized using LDH NPs, exhibiting high catalytic performance. The basic surface OH groups of LDH would be also beneficial for deprotonation of alcohols and heterolytic dissociation of H2 in the catalytic reactions.
Hydrophilic Ultra‐Fine SiC Nanowires Enhance the Performance of Hydrated Salt Phase‐Change Energy Storage Materials
Authors: Chen Wenchao , Chen Qi , Yu Yajie , Gao Huabo , Ma Bin 
Published: October 2024

AbstractIn this study, ultrafine linear nanostructured SiC with high wettability and large specific surface area were synthesized via the carbothermal reduction method. These nanowires were impregnated with Na2SO4 ⋅ 10H2O, CaCl2 ⋅ 6H2O, MgCl2 ⋅ 6H2O, and CaMg2Cl6 ⋅ 12H2O to obtain composite phase change materials (CPCMs), which demonstrated improved phase separation and significantly reduced supercooling. In particular, the supercooling degree of CaCl2 ⋅ 6H2O was minimized to 0.1 °C. The SiC nanowires effectively prevented issues of dehydration and deliquescence in hydrated salts. The thermal storage capacities of the CPCMs exceeded 90 %, with Na2SO4 ⋅ 10H2O and MgCl2 ⋅ 6H2O reaching 107.10 % and 103.35 %, respectively. Furthermore, the CPCMs exhibited greater sensitivity to changes in temperature compared with the pure hydrated salt phase change materials (PCMs). These results indicate that ultra‐fine SiC nanowires can act as a versatile carrier for hydrated salt PCMs at low and intermediate temperatures.
Corporate hypocrisy and ESG rating divergence
Authors: He Renxiang , Chen Hongtao , Zhu Xiang 
Published: October 2024

AbstractWe draw upon impression management theory and cognitive dissonance theory to examine whether or not corporate hypocrisy triggers substantial environmental, social, and governance (ESG) rating divergence and to further investigate the influence channels of cognitive dissonance and impression management. In addition, our study explores the moderating role of media coverage with different emotional biases in shaping the relationship between corporate hypocrisy and ESG rating divergence. By utilizing a comprehensive dataset comprising 3562 Chinese listed companies and 25,898 firm‐year observations from 2010 to 2022, findings reveal that hypocritical firms exhibit significantly large ESG rating divergence. In particular, these firms induce cognitive dissonance among rating agencies, resulting in rating disparities, which are further magnified when using impression management through the selective disclosure of negative information or symbolic promotion of positive information. Furthermore, positive media coverage weakens the positive association between corporate hypocrisy and ESG rating divergence, whereas negative media coverage strengthens this relationship. Lastly, we find that the impact of corporate hypocrisy on ESG rating divergence is more pronounced for companies with higher average ESG scores, lower long‐term charitable involvement, and lower information opacity. These findings withstand various sensitivity tests utilizing alternative measures for rating divergence and corporate hypocrisy, as well as different sample compositions. Our conclusions remain robust even after addressing endogeneity concerns using a two‐stage least squares regression model.
Aqueous‐Based Assembly of Plant‐Derived Proteins Yields a Crosslinker‐Free Biodegradable Bioplastic Consistent with Green Chemistry Principles
Authors: Sarkar Amit Kumar , Yang Ziyu , Astruc Tal , Amdursky Nadav 
Published: October 2024

AbstractPlastics are an indispensable part of modern life. Due to the harmful environmental consequences of petroleum‐based plastic usage, there is an urgent need to replace them with biodegradable bioplastics that meet the sustainability standards required for a low environmental footprint. Here, we use plant‐derived proteins to produce bioplastics. Since most plant‐derived proteins are not water‐soluble, there has always been a need to use acidic or basic solutions or organic solvents with plasticizers and crosslinkers to produce bioplastic. Here, we present a counterintuitive approach for using water‐insoluble plant‐derived soy and pea proteins to manufacture large‐scale bioplastics using only water as a solvent without common plasticizers or crosslinkers. We show that bioplastics can form via a self‐assembly process initiated by a small molecular initiator while maintaining favourable mechanical properties. The lack of crosslinking and the protein nature of the bioplastic leads to a rapid biodegradation process under various conditions. Overall, the approach we present is highly attractive in terms of cost and time, and most importantly, it obeys all the relevant principles of green chemistry in bioplastics production.
Liquid biopsy—A biomarker‐based revolutionising technique in cancer therapy
Authors: Sarkar Subham , Chakraborty Samraggi , Ghosh Soubhagya , Chowdhury Ekanansha Roy , Rajak Jenifer , Mitra Arup Kumar , Kumer Ajoy , Dhara Bikram 
Published: October 2024

AbstractBackground and AimsCancer has grabbed the attention of scientists and medical professionals all over the world much more than any other disease. In the past few decades, the medical field has improved quite a lot but progress in the path to find a solution for cancer is very less. As the popularity of invasive technologies is diminishing in cancer treatment, scientists have come up withminimally invasive or non‐invasive alternatives, among which liquid biopsy, by far is the most suitable.MethodsLiquid biopsy is used to analyse nucleic acids, subcellular components and circulating tumour cells in various biological fluids for diagnosis of cancer. It can also be used to know the efficacy of cancer drugs in a patient by analysing multiple samples.OutcomesLiquid biopsy is becoming standard of care as it allows biopsy of those samples in which solid tumour biopsies are not possible. The diversity of sampling procedures, such as collection of urine for urothelial carcinoma or bladder or prostate cancer and phlebotomy for other types of cancer, make liquid biopsy one of the best methods for diagnosis of cancer.ConclusionThis review aims in discussing the several techniques used for the detection of cancer biomarkers and some clinical manifestations due to the changes in the biomarkers which are analysed by liquid biopsy.
EphB2, EphB4, and ephrin‐B1 expression and localization in postnatal developing epididymis in mice
Authors: Gofur Md. Royhan , Ogawa Kazushige 
Published: October 2024

AbstractBackgroundEph receptors and ephrin ligands, the transmembrane proteins, function as a mechanism of communication between cells. Therefore, we intended to explore the expression array of EphB2 and EphB4 receptors and ephrin‐B1 ligand in postnatal developing mouse epididymis during 1 day to 8 weeks using RT‐PCR amplification and immunofluorescence staining.ResultsRT‐PCR analysis indicated that the expression levels of EphB2, EphB4, and ephrin‐B1 in the epididymis declined with the advancement of age during the initial phases of postnatal development and stayed relatively near to adult levels until 4 weeks. We discovered that the predominant compartments expressing EphB2/B4 and ephrin‐B1 emerged in the excurrent duct epithelia of postnatal developing epididymis until 3 weeks. Consequently, even before spermatozoa reach the excurrent duct in epididymis, at the age of 3 weeks, the epididymal excurrent duct system exhibits characteristics similar to those of an adult in terms of expression of EphB2/B4 and ephrin‐B1. Moreover, ephrin‐B1 was expressed in epididymal epithelial cells throughout the development and EphB4 was expressed only in early postnatal stages while basal cells expressed EphB4 throughout the postnatal development.ConclusionThe study represents the first expression analysis of ephrin‐B1, EphB2, and EphB4 in the normal mouse epididymis during the postnatal development.