bluuebunny/crossref_metadata_2025_split huggingface dataset:
Irish national real-world analysis of the clinical and economic impact of 21-gene oncotype DX® testing in early-stage, 1-3 lymph node-positive, oestrogen receptor-positive, HER2-negative, breast cancer
Authors: Browne I. M. , McLaughlin R. A. , Weadick C. S. , O’Sullivan S. , McSorley L. M. , Hadi D. K. , Millen S. J. , Higgins M. J. , Crown J. P. , Prichard R. S. , McCartan D. P. , Hill A. DK. , Connolly R. M. , Noonan S. A. , O’Mahony D. , Murray C. , O’Hanlon-Brown C. , Hennessy B. T. , Quinn C. M. , Kelly C. M. , O’Reilly S. , Morris P. G. , Walshe J. M. 
Published: October 2024

Abstract

Purpose
The treatment landscape of Oestrogen receptor-positive (ER-positive) breast cancer is evolving, with declining chemotherapy use as a result of Oncotype DX Breast Recurrence Score® testing. Results from the SWOG S1007 RxPONDER trial suggest that adjuvant chemotherapy may benefit some premenopausal women with ER-positive, HER2-negative disease with 1–3 positive lymph nodes (N1), and a Recurrence Score® (RS) of ≤ 25. Postmenopausal women with similar characteristics did not benefit from adjuvant chemotherapy. We examine the clinical and economic impact of Oncotype DX® testing on treatment decisions in patients with N1 disease in Ireland using real world data.

Methods
From March 2011 to October 2022, a retrospective, cross-sectional observational study was performed of patients with ER-positive, HER2-negative N1 breast cancer, who had Oncotype DX testing across 5 of Ireland’s largest cancer centres. Patients were classified into low risk (RS 0–13), intermediate risk (RS 14–25) and high risk (RS > 25). Data were collected via electronic patient records. Information regarding costing was provided primarily by pre-published sources.

Results
A total of 828 N1 patients were included in this study. Post Oncotype DX testing, 480 patients (58%) were spared chemotherapy. Of the patients who had a change in chemotherapy recommendation based on Oncotype DX testing, 271 (56%), 205 (43%), 4 (1%) had a RS result of 0–13, 14–25 and > 25 respectively. Use of Oncotype DX testing was associated with a 58% reduction in chemotherapy administration overall. This resulted in estimated savings of over €6 million in treatment costs. Deducting the assay cost, estimated net savings of over €3.3 million were achieved. Changes in the ordering demographics of Oncotype DX tests were identified after RxPONDER data were presented, with increased testing in women ≥ 50 years and a reduction in proportion of tests ordered for women < 50 years.

Conclusion
Between 2011 and 2022, assay use resulted in a 58% reduction in chemotherapy administration and net savings of over €3.3 million.
Carceral Logics in Benevolent Places: How Institutions of Care Criminalize Justice-Involved Black Mothers
Authors: Mondé Geniece Crawford 
Published: October 2024

AbstractScholarship examining the challenges that formerly incarcerated mothers experience after imprisonment often focuses on how their ex-offender status limits opportunities and leaves them alienated from their roles as citizens and as mothers. What is less understood however, is how women experience social exclusion from institutions that they initially perceive as supportive. Interviews with 33 formerly incarcerated Black mothers reveal how women respond to negative experiences with institutions after their imprisonment and how they interpret similar encounters of marginalization prior to their arrest and incarceration. In taking a life history approach to examining women’s experiences with social service agencies, this analysis examines the interplay between carceral logics, and the institutions purposed with facilitating women’s reintegration. The paper introduces the concept carceral logics of benevolence to capture how institutions that marginalized groups rely upon to extend benevolence, often further marginalize already vulnerable groups. Findings reveal that women interpret and respond to carceral logics of benevolence by engaging in institutional cynicism and drawing upon repertories of systemic marginalization.
Task Characteristics Associated with Mathematical Word Problem-Solving Performance Among Elementary School-Aged Children: A Systematic Review and Meta-Analysis
Authors: Vessonen T. , Dahlberg M. , Hellstrand H. , Widlund A. , Korhonen J. , Aunio P. , Laine A. 
Published: October 2024

AbstractMathematical word problem-solving skills are crucial for students across their lives, yet solving such tasks poses challenges for many. Therefore, understanding the characteristics of mathematical word problems that are associated with students’ performance is important. The objective of this systematic review and meta-analysis was to evaluate the effects of linguistic and numerical task characteristics associated with mathematical word problem-solving performance among elementary school-aged children (Grades 1 to 6). The systematic review was based on five electronic databases and citation searching. Reporting was conducted following The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). The findings (K = 69) showed that five of the six investigated linguistic task characteristics (i.e., the position of the unknown, schematic structure, irrelevant information, realistic considerations, and lexical consistency) and one of the two numerical task characteristics (i.e., number of operations) were related (g = 0.39 to 4.26) with elementary school-aged children’s mathematical word problem-solving. However, the findings did not provide support for a general association between a familiar situational narrative or the required operation with mathematical word problem-solving. The findings highlight that elementary school-aged children especially struggle with mathematical word problems requiring realistic considerations or multiple mathematical operations, containing lexical inconsistency, and problems in which the position of the unknown is the first value. This further understanding of elementary schoolers’ word problem-solving performance may guide the design of appropriate and progressive instruction and assessment tools and steer research into the interactions within task characteristics and with individual characteristics.
An Empirical Analysis of Spot and Forward Interest Rates in Seven European Countries via Principal Component Analysis and the Malliavin-Mancino Method
Authors: Liu Nien-Lin , Suzuki Ryoichi 
Published: October 2024

AbstractBuilding upon the empirical studies by Liu (2:57–60, 2010) and Liu and Mancino (2012), we investigate the determinants influencing the term structure of interest rates in seven European countries: Austria, Belgium, Britain, France, Germany, Italy, and Spain. We use two methods, namely principal component analysis (PCA) for covariance matrix estimated by realized volatility estimator and PCA of integrated volatility estimated by Malliavin-Mancino (MM) estimator using Fourier series method proposed by Malliavin and Mancino (6:49–61, 2002; 37: 1983–2010, 2009), to examine spot rates and forward rates derived from zero-coupon bond data. The results of the study confirm that although three factors account for the majority of spot rate variability, a more significant number of factors is essential to capture forward rate dynamics adequately. This research complements the results established by earlier studies, providing a more comprehensive understanding of interest rate dynamics across these European markets.
A novel high-resolution technique for the study of deep energy levels in semiconductors based on computerized Laplace-DLTS
Authors: Sánchez-Castro Angel D. , Kudriavtsev Yuriy , Rivera-Álvarez Zacarías 
Published: October 2024

AbstractThis paper describes a new computerized system for investigating deep levels in semiconductors by DLTS. We used a modified measurement mode, a new approach based on the inverse Laplace transform, and a new data processing algorithm. The developed method uses only a few transients derived and averaged from DLTS measurements at heating rates up to 2 °C/min, combined with low-frequency pulses. The paper presents data obtained for a phosphorus-doped silicon PIN diode, previously investigated using a conventional computerized DLTS system. Our new method allowed us to detect three electronic levels with energies of Ec – 0.53 eV, Ec – 0.39 eV, and Ec – 0.38 eV in less than 1 h, while the conventional DLTS system detected only two levels: Ec – 0.53 eV and Ec – 0.42eV. Thus, we have shown that the new approach drastically reduces the measurement time and increases the resolution.
Trying to find Safety, to make it Speakable, and to Mourn the Losses – Children’s Recovery from Domestic Abuse
Authors: Morrison Fiona 
Published: October 2024

Abstract
Purpose
This article addresses a gap in our understanding of children’s ‘recovery’ from domestic abuse. Whilst the impacts of domestic abuse on children have been well-documented and researched, their recovery from it has been under-theorized. By analyzing qualitative accounts on children’s participation in recovery programmes, the article uses Judith Herman’s trauma recovery model, to make the how of children’s recovery explicit.

Methods
Conducted in Scotland, the research involved individual qualitative interviews with 14 children (aged 7-15 years) and their 14 mothers, who had completed Cedar, a 12-week therapeutic and peer support group programme. A co-produced approach to initial data analysis foregrounded children and mothers’ own priorities for children’s recovery and afforded findings greater rigor. These priorities were then further analyzed using Herman’s trauma recovery framework.

Findings
Findings offer insight on the ways in which structures, resources, and values designed into the recovery programmes can mobilize children’s experiences of domestic abuse to help them find safety; make domestic abuse ‘speakable’; as well as provide space for children to mourn the losses resulting from domestic abuse. Findings further indicate the power of group-based interventions and the ways in which they can promote recovery through ideas of nurture and care.

Conclusions
By using Herman’s theoretical lens for recovery, the article makes a new contribution to understandings of children’s recovery from domestic abuse. It identifies key factors that contribute to children’s ability to recover including: their sense of safety, the role of the mother–child relationship and significance of the child-father relationship.
Plasticization of Polylactide Using Biobased Epoxidized Isobutyl Esters Derived from Waste Soybean Oil Deodorizer Distillate
Authors: Najera-Losada L. , Narváez-Rincón P. C. , Orjuela A. , Gomez-Caturla J. , Fenollar O. , Balart R. 
Published: October 2024

AbstractA series of epoxidized isobutyl esters (EIE) derived from soybean oil deodorizing distillate (SODD) were synthesized via esterification with isobutanol followed by epoxidation. Epoxidized isobutyl soyate (EIS), epoxidized isobutyl soyate distillate (EISD), as well as the epoxidized esters of the main fatty acids contained in SODD, namely, epoxidized isobutyl linoleate (EIL), and epoxidized isobutyl oleate (EIO) were also synthesized and assessed as environmentally friendly plasticizers for polylactide (PLA). A comparison of the plasticizing efficiency of 10 wt.% of these EIE on PLA properties is addressed in this work. The effects of the different EIE on mechanical properties (tensile and impact tests) at 21 ºC, thermal transitions and thermal degradation, dynamic-mechanical thermal properties and dimensional change with temperature, and morphology are evaluated and compared with commercial epoxidized soybean oil (ESBO), and acetyl tributyl citrate (ATBC). Tensile tests indicate that EIE provide increased elongation at break from 8.8% (neat PLA), up to 10–32%, depending on the EIE. EIE seem to be more compatible with PLA as observed by field emission scanning electron microscopy (FESEM) since they do not give evidence of phase separation, or plasticizer saturation, which is clearly observed with ESBO. Regarding thermal properties, all EIE provide a noticeable decrease in the glass transition temperature (Tg) from 61.6 ºC (neat PLA), down to values ranging from 42 to 48 ºC, remarkably lower than the decrease provided by ESBO with a Tg value of 56.6 ºC. These findings reveal that EIE are promising plasticizers for PLA with balanced properties and contribute to improve its intrinsic brittleness by increasing the impact toughness.
Effect of Epoxy Chain Extender and Multiple Processing on Poly-(R)-3-Hydroxybutyrate’s Properties
Authors: Hinterberger Klaus , Main Priyanka , Waly Christoph , Lucyshyn Thomas 
Published: October 2024

AbstractThe semi-crystalline poly-(R)-3-hydroxybutyrate (PHB) is a biobased and biodegradable polymer. This makes it a promising alternative to polypropylene (PP), especially for packaging applications. PHB has excellent barrier properties to O2, CO2, and H2O, but is susceptible to degradation from heat and hydrolysis. The epoxy chain extender Joncryl® was added to PHB in a simulated recycling process to reverse the degradation due to processing. The effects of the chain extender and the degradation due to processing were investigated with thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), small strain oscillatory plate-plate rheometry, tensile tests, and notched Charpy impact tests. With the addition of the chain extender, a decrease in peak crystallization temperature and tensile modulus, and an increase in zero-shear viscosity and elongation at break were observed. For each additional processing step the zero-shear viscosity, the elongation at break, and the notched impact strength decreased, while the tensile modulus increased. The effect of the thermal load during processing on the material properties is significantly higher compared to the effect of the addition of the chain extender. Therefore, the practical application of the investigated chain extender alone in a multi-stage recycling process seems limited. This is due to the low processing temperature of PHB, which seems to limit the full potential of Joncryl® due to the slow reaction speed at this temperature.
Chromatographic separation of Re-188 from reactor produced W-188 using Bio-Rex 5 anion exchange resin
Authors: Gizawy Mohamed A. , Ebrahiem Ebrahiem Esmail , Abobeah R. M. , Aboul-Fotouh Tarek M. , Yaseen Amr Ahmad 
Published: October 2024

AbstractRhenium-188 (188Re) is a β−emitting radionuclide with a significant potential for use in targeted radionuclide therapy. The current study set out to assess the possibility of producing 188Re through double neutron capture on 186W at the Egyptian Second Research Reactor (ETRR-2). Using the MCNPX2.7.0 code, the neutron activation of a naturally occurring tungsten target positioned at the highest thermal neutron flux was simulated. There was a little discrepancy between the calculated results and the experimental data. The feasibility of using Bio-Rex 5 anionic resin for developing an 188W/188Re chromatographic generator was investigated using static and dynamic studies. Our results showed that a high adsorption capacity of 240 mg/g towards WO42− was attained. Additionally, more than 97.3 ± 0.6% of the 188Re could be recovered from the generator in the first 3 mL, with high chemical, radiochemical, and radionuclidic purities adequate for radiopharmaceutical preparations as well as clinical applications.
Applicability of atomic force microscopy for nuclear forensic examination
Authors: Tóbi Csaba , Khánh Nguyen Quoc , Homonnay Zoltán , Széles Éva 
Published: October 2024

AbstractThe applicability of the Atomic Force Microscopy (AFM) was examined for nuclear forensic purposes. The hyper-stoichiometric form of uranium-oxide was identified as novel signature which indicates the production technology of uranium fuel pellets. The AFM technique was compared with Scanning Electron Microscope (SEM) that is usually used for morphological study in nuclear forensics. AFM has some unique features comparing with SEM and as a fast and less expensive technique, it can be a good alternative solution or a supporting technique to the SEM.
Graphical abstract
Investigating Knowledge Flows in Scientific Communities: The Potential of Bibliometric Methods
Authors: Aman Valeria , Gläser Jochen 
Published: October 2024

AbstractIn their everyday work, scholars constantly acquire and transfer knowledge. Many of these knowledge flows are difficult to observe, not least because scholars are often not aware of them. This may be the reason why the attention to knowledge flows is very unevenly distributed across science studies, with bibliometric citation-based studies contributing the most research. Starting from the premise that bibliometric methods can be more readily exploited in the study of knowledge flows, this review explores the potential of bibliometric methods for the investigation of knowledge flows. Bibliometrics provides a portfolio of data and methods that can be used alone or in combination with qualitative methods to study knowledge flows. We organise contributions to the study of knowledge flows according to their object of study—formal, informal, or tacit knowledge—and according to the mode of flow—impersonal or interpersonal knowledge flow. The review shows that bibliometrics is strongly focused on the use of citation data for the investigation of impersonal flows of formal knowledge and has recently turned to the impersonal flow of informal knowledge via social media. In contrast, there are only few bibliometric studies that address interpersonal flows of knowledge. The review identifies an under-utilised potential of bibliometric methods and suggests some directions for future methodological development.
Impact of instrumentation material on local recurrence: a case-matched series using carbon fiber-PEEK vs. titanium
Authors: Ward Jacob , Damante Mark , Wilson Seth , Coelho Vicente , Franceschelli Dominic , Elguindy Ahmed Nader , Thomas Evan M. , Zhu Simeng , Blakaj Dukagjin , Beyer Sasha , Raval Raju , Singh Raj , Xu David S. , Elder J. Bradley , Palmer Joshua D. , Chakravarthy Vikram B. 
Published: October 2024

Abstract
Purpose
Spine metastases are a major burden of oncologic care, contributing to substantial morbidity. A well-established treatment paradigm for patients with metastatic epidural spinal cord compression includes separation surgery followed by stereotactic body radiotherapy (SBRT). Innovations in implant technology have brought about the incorporation of Carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation for spinal fixation. We present our experience of CFR-PEEK instrumentation, comparing outcomes and complication profiles with a matched cohort of titanium instrumented cases for spine metastatic disease.

Methods
Oncology patients who underwent spinal fusion for metastatic spine disease from 2012 to 2023 were retrospectively reviewed. Ninety-nine cases with CFR-PEEK fusions were case-control matched with 50 titanium controls (2:1 ratio) based upon primary tumor type and spinal instability neoplastic score (SINS) location. Demographic, clinical, radiographic and progression free survival (PFS) were analyzed.

Results
In the study years, 263 patients underwent spinal decompression and fusion, for which 148 patients met predetermined inclusion criteria. Of these, 49 had titanium instrumentation, and 99 had CFR-PEEK. Complication profiles, including hardware failure and infection were similar between the groups. There was no significant difference in PFS between all CFR-PEEK and titanium patients (143 days versus 214 days; p = 0.41). When comparing patients in which recurrence was noted, CFR-PEEK patients had recurrence detected two times earlier than titanium patients (94 days versus 189 days; p = 0.013).

Conclusion
In this case matched cohort, CFR-PEEK demonstrated decreased overall PFS suggestive of earlier local recurrence identification. Long-term studies are warranted for better evaluation of the impact on survival and systemic disease progression.
Are We Getting Closer to Consensus? An Analysis of Changes in Socially Perceived Necessities Over Time in Japan
Authors: Abe Aya 
Published: October 2024

AbstractThe measurement of poverty using the material deprivation scale has become widespread throughout the world. One of the technical challenges in constructing the material deprivation scale is the identification of socially perceived necessities. Researchers have used methods ranging from focus groups to separate public opinion surveys to develop a list of socially perceived necessities. However, material deprivation is a relative concept. As society undergoes economic, demographic and political change, the list needs to be reviewed for relevance. The aim of this study was to examine the stability of perceptions of children's necessities in Japan at a time when public awareness of child poverty in Japan has risen sharply. The results of the analysis show that, using the 50% criterion, the list of socially perceived necessities for children has been surprisingly stable over 20 years. However, there has been a statistically significant change in the public's perception of necessity for 16 of the 25 items, even after controlling for age, gender, income and whether they have children. Furthermore, the analysis shows that although the consensus between genders and between income quintile groups is fairly stable or converging, there is a greater divergence in the consensus between age groups and between respondents with and without children. In a society with increasing numbers of elderly and childless people, we need to be increasingly careful that the items selected for the deprivation scale not only meet the 50% criteria, but are also agreed by different segments of the population.
The Manipulationist Threat to moral responsibility
Authors: Moody Kristoffer 
Published: October 2024

AbstractStandard compatibilist accounts adjudicating when individuals are morally responsible for their actions are predicated on the assumption that individuals will have responsibility for the valuational structure undergirding their actions. However, I will claim that evidence from psychology and social psychology seems to show that manipulation of our valuational structure, far from being esoteric, is more common than we might pre-theoretically think. I call this evidence of manipulation the Manipulationist Threat. Given the Manipulationist Threat, I will argue that the strategies employed by reasons-responsiveness and Deep Self accounts for responding to manipulation are inadequate; they fail at either giving appropriate excusing conditions, or explaining why individuals subject to manipulation maintain responsibility.
Random Walk Modeling of Conductive Heat Transport in Discontinuous Media
Authors: Baioni Elisa , Lejay Antoine , Pichot Géraldine , Porta Giovanni Michele 
Published: October 2024

AbstractWe consider heat transport within a discontinuous domain by relying on the modeling approach proposed by Baioni et al. Such approach has been specifically designed to address diffusive processes in media with discontinuous physical properties and generalized boundary conditions at the discontinuities. Three algorithms are here applied to estimate the conductive heat transport in a bimaterial medium. The algorithms undergo testing using two test cases that share the same computational domain but differ in terms of their initial conditions. According to the numerical results all the algorithms ensure the conservation of thermal energy and preserve thermal equilibrium under steady state conditions. The Generalized Uffink Method (GUM) and Generalized HYMLA demonstrate sensitivity to the choice of the time step, whereas the Generalized Skew Brownian Motion appears to be unaffected by the value of $$\Delta t$$

Δ
t

. The GUM algorithm presents an optimal trade-off between accuracy and computational time.