bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconciling Regulatory Space with External Accountability through WTO Adjudication – Trade, Environment and Development
Authors: WEIMER MARIA 
Published: July 2017

AbstractThis article argues in favour of broadening the trade and environment debate in the World Trade Organization (WTO) to include a developmental perspective. WTO litigation involving environmental regulation touches upon the issue of global justice and the power asymmetries structurally embedded in the global economy. The recognition of the WTO as a legitimate global institution, therefore, depends on its ability to reconcile the respect for the right to regulate with the need to give due regard to the interests and concerns of foreign constituencies affected by domestic regulation. By imposing other-regarding obligations, WTO law can act as a mechanism of external accountability of powerful states vis-à-vis affected foreigners, especially where asymmetric relations and different stages of economic development are involved. The article applies this framework to analyze the legal reasoning of the Appellate Body in theUS-Tuna IIdispute between the US and Mexico – a dispute illustrating the complex intertwinement between economic, environmental and developmental issues. It concludes that the use of the concepts of ‘even-handedness’ and ‘calibration’ under Article 2.1 of the Technical Barriers to Trade Agreement and Article XX of the General Agreement on Tariffs and Trade did not enable the Appellate Body to strike an adequate balance between the right to regulate and external accountability. While in the original report the Appellate Body used ‘even-handedness’ to impose only a minimal level of external accountability on the US, in the compliance report, the Appellate Body has gone too far by failing to defer to the US risk assessment amidst scientific controversy and uncertainty.
Europeanisation and Catalonia’s in(ter)dependence
Authors: MORENO LUIS 
Published: July 2017

Abstract:The European Union has transcended many of the old prerogatives of national independence bringing about the very function of interdependence among Member States. Within the latter there are sub-state communities claiming simultaneously both self-government and ‘more Europe’. The future intent of this political process in the Old Continent is to make territorial subsidiarity consistent with home rule within European framework legislation and continental institutions. The first part of this article focuses on the idea of a closer European Union based upon the implementation of territorial subsidiarity, as well as on the challenges posed by democratic accountability, multi-level governance and the preservation of the European Social Model (ESM). The second section illustrates some of these challenges in practice through an analysis of how the meaning of independence has developed in a ‘stateless nation’ such as Catalonia. In Spain, the lack of territorial accommodation, together with a long-standing centre–periphery controversy, has fuelled claims for secession by some Catalan nationalists. The conclusions ponder on how ‘cosmopolitan localism’ can optimise both independence and interdependence of stateless nations like Catalonia in the global context.
Indigenous autonomy in Colombia: State-building processes and multiculturalism
Authors: RUEDA-SAIZ PABLO 
Published: July 2017

Abstract:This article shows a novel facet in the complex relation between multiculturalism, the state and the market. Contrary to conventional theories in political science, sociology and anthropology, it shows that it is not just the success, but also the failure of the state and the market to commoditise nature and turn it into property that can actually help to foster ethnic identity. While state-driven market incentives to expand the agricultural frontier in Colombia during the 1960s and 1970s failed, they did help to foster differentiated indigenous identities and organisations, which converged around the revival of long-forgotten nineteenth century indigenous laws and other political opportunities to reclaim lands that had been taken away from them. Moreover, this article also shows that during a period of institutional openness in the late 1980s and early 1990s, the political emergence of indigenous identities became an important component of Colombia’s state-building processes by helping this country to maintain its territorial integrity through a model of delegated indigenous governance.
The smectic order of wrinkles
Authors: Aharoni Hillel , Todorova Desislava V. , Albarrán Octavio , Goehring Lucas , Kamien Randall D. , Katifori Eleni 
Published: July 2017

AbstractA thin elastic sheet lying on a soft substrate develops wrinkled patterns when subject to an external forcing or as a result of geometric incompatibility. Thin sheet elasticity and substrate response equip such wrinkles with a global preferred wrinkle spacing length and with resistance to wrinkle curvature. These features are responsible for the liquid crystalline smectic-like behaviour of such systems at intermediate length scales. This insight allows better understanding of the wrinkling patterns seen in such systems, with which we explain pattern breaking into domains, the properties of domain walls and wrinkle undulation. We compare our predictions with numerical simulations and with experimental observations.
Crystalline metamaterials for topological properties at subwavelength scales
Authors: Yves Simon , Fleury Romain , Berthelot Thomas , Fink Mathias , Lemoult Fabrice , Lerosey Geoffroy 
Published: July 2017

AbstractThe exciting discovery of topological condensed matter systems has lately triggered a search for their photonic analogues, motivated by the possibility of robust backscattering-immune light transport. However, topological photonic phases have so far only been observed in photonic crystals and waveguide arrays, which are inherently physically wavelength scaled, hindering their application in compact subwavelength systems. In this letter, we tackle this problem by patterning the deep subwavelength resonant elements of metamaterials onto specific lattices, and create crystalline metamaterials that can develop complex nonlocal properties due to multiple scattering, despite their very subwavelength spatial scale that usually implies to disregard their structure. These spatially dispersive systems can support subwavelength topological phases, as we demonstrate at microwaves by direct field mapping. Our approach gives a straightforward tabletop platform for the study of photonic topological phases, and allows to envision applications benefiting the compactness of metamaterials and the amazing potential of topological insulators.
Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
Authors: Teichert Martin , Milde Laura , Holm Annegret , Stanicek Laura , Gengenbacher Nicolas , Savant Soniya , Ruckdeschel Tina , Hasanov Zulfiyya , Srivastava Kshitij , Hu Junhao , Hertel Stella , Bartol Arne , Schlereth Katharina , Augustin Hellmut G. 
Published: July 2017

AbstractThe Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has not been unravelled through which mechanisms pericyte Angiopoietin/Tie signalling affects angiogenesis. Here we show that human and murine pericytes express functional Tie2 receptor. Silencing of Tie2 in pericytes results in a pro-migratory phenotype. Pericyte Tie2 controls sprouting angiogenesis in in vitro sprouting and in vivo spheroid assays. Tie2 downstream signalling in pericytes involves Calpain, Akt and FOXO3A. Ng2-Cre-driven deletion of pericyte-expressed Tie2 in mice transiently delays postnatal retinal angiogenesis. Yet, Tie2 deletion in pericytes results in a pronounced pro-angiogenic effect leading to enhanced tumour growth. Together, the data expand and revise the current concepts on vascular Angiopoietin/Tie signalling and propose a bidirectional, reciprocal EC-pericyte model of Tie2 signalling.
Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing
Authors: Farlie Peter G. , Davidson Nadia M. , Baker Naomi L. , Raabus Mai , Roeszler Kelly N. , Hirst Claire , Major Andrew , Mariette Mylene M. , Lambert David M. , Oshlack Alicia , Smith Craig A. 
Published: July 2017

AbstractThe ratites are a distinctive clade of flightless birds, typified by the emu and ostrich that have acquired a range of unique anatomical characteristics since diverging from basal Aves at least 100 million years ago. The emu possesses a vestigial wing with a single digit and greatly reduced forelimb musculature. However, the embryological basis of wing reduction and other anatomical changes associated with loss of flight are unclear. Here we report a previously unknown co-option of the cardiac transcription factorNkx2.5to the forelimb in the emu embryo, but not in ostrich, or chicken and zebra finch, which have fully developed wings.Nkx2.5is expressed in emu limb bud mesenchyme and maturing wing muscle, and mis-expression ofNkx2.5throughout the limb bud in chick results in wing reductions. We propose thatNkx2.5functions to inhibit early limb bud expansion and later muscle growth during development of the vestigial emu wing.
Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
Authors: Wehner Daniel , Tsarouchas Themistoklis M. , Michael Andria , Haase Christa , Weidinger Gilbert , Reimer Michell M. , Becker Thomas , Becker Catherina G. 
Published: July 2017

AbstractThe inhibitory extracellular matrix in a spinal lesion site is a major impediment to axonal regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial axon re-growth, leading to recovery of movement. However, little is known about regulation and composition of the growth-promoting extracellular matrix. Here we demonstrate that activity of the Wnt/β-catenin pathway in fibroblast-like cells in the lesion site is pivotal for axon re-growth and functional recovery. Wnt/β-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment. Overexpression of col12a1a rescues the effects of Wnt/β-catenin pathway inhibition and is sufficient to accelerate regeneration. We demonstrate that in a vertebrate of high regenerative capacity, Wnt/β-catenin signaling controls the composition of the lesion site extracellular matrix and we identify Collagen XII as a promoter of axonal regeneration. These findings imply that the Wnt/β-catenin pathway and Collagen XII may be targets for extracellular matrix manipulations in non-regenerating species.
An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins
Authors: Li Song , Koe Chwee Tat , Tay Su Ting , Tan Angie Lay Keng , Zhang Shenli , Zhang Yingjie , Tan Patrick , Sung Wing-Kin , Wang Hongyan 
Published: July 2017

AbstractThe switch between quiescence and proliferation is central for neurogenesis and its alteration is linked to neurodevelopmental disorders such as microcephaly. However, intrinsic mechanisms that reactivate Drosophila larval neural stem cells (NSCs) to exit from quiescence are not well established. Here we show that the spindle matrix complex containing Chromator (Chro) functions as a key intrinsic regulator of NSC reactivation downstream of extrinsic insulin/insulin-like growth factor signalling. Chro also prevents NSCs from re-entering quiescence at later stages. NSC-specific in vivo profiling has identified many downstream targets of Chro, including a temporal transcription factor Grainy head (Grh) and a neural stem cell quiescence-inducing factor Prospero (Pros). We show that spindle matrix proteins promote the expression of Grh and repress that of Pros in NSCs to govern their reactivation. Our data demonstrate that nuclear Chro critically regulates gene expression in NSCs at the transition from quiescence to proliferation.
Spin caloritronic nano-oscillator
Authors: Safranski C. , Barsukov I. , Lee H. K. , Schneider T. , Jara A. A. , Smith A. , Chang H. , Lenz K. , Lindner J. , Tserkovnyak Y. , Wu M. , Krivorotov I. N. 
Published: July 2017

AbstractEnergy loss due to ohmic heating is a major bottleneck limiting down-scaling and speed of nano-electronic devices, and harvesting ohmic heat for signal processing is a major challenge in modern electronics. Here, we demonstrate that thermal gradients arising from ohmic heating can be utilized for excitation of coherent auto-oscillations of magnetization and for generation of tunable microwave signals. The heat-driven dynamics is observed in Y3Fe5O12/Pt bilayer nanowires where ohmic heating of the Pt layer results in injection of pure spin current into the Y3Fe5O12 layer. This leads to excitation of auto-oscillations of the Y3Fe5O12 magnetization and generation of coherent microwave radiation. Our work paves the way towards spin caloritronic devices for microwave and magnonic applications.
Structural basis for dolichylphosphate mannose biosynthesis
Authors: Gandini Rosaria , Reichenbach Tom , Tan Tien-Chye , Divne Christina 
Published: July 2017

AbstractProtein glycosylation is a critical protein modification. In biogenic membranes of eukaryotes and archaea, these reactions require activated mannose in the form of the lipid conjugate dolichylphosphate mannose (Dol-P-Man). The membrane protein dolichylphosphate mannose synthase (DPMS) catalyzes the reaction whereby mannose is transferred from GDP-mannose to the dolichol carrier Dol-P, to yield Dol-P-Man. Failure to produce or utilize Dol-P-Man compromises organism viability, and in humans, several mutations in the human dpm1 gene lead to congenital disorders of glycosylation (CDG). Here, we report three high-resolution crystal structures of archaeal DPMS from Pyrococcus furiosus, in complex with nucleotide, donor, and glycolipid product. The structures offer snapshots along the catalytic cycle, and reveal how lipid binding couples to movements of interface helices, metal binding, and acceptor loop dynamics to control critical events leading to Dol-P-Man synthesis. The structures also rationalize the loss of dolichylphosphate mannose synthase function in dpm1-associated CDG.
Long-term hepatitis B infection in a scalable hepatic co-culture system
Authors: Winer Benjamin Y. , Huang Tiffany S. , Pludwinski Eitan , Heller Brigitte , Wojcik Felix , Lipkowitz Gabriel E. , Parekh Amit , Cho Cheul , Shrirao Anil , Muir Tom W. , Novik Eric , Ploss Alexander 
Published: July 2017

AbstractHepatitis B virus causes chronic infections in 250 million people worldwide. Chronic hepatitis B virus carriers are at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma. A prophylactic vaccine exists and currently available antivirals can suppress but rarely cure chronic infections. The study of hepatitis B virus and development of curative antivirals are hampered by a scarcity of models that mimic infection in a physiologically relevant, cellular context. Here, we show that cell-culture and patient-derived hepatitis B virus can establish persistent infection for over 30 days in a self-assembling, primary hepatocyte co-culture system. Importantly, infection can be established without antiviral immune suppression, and susceptibility is not donor dependent. The platform is scalable to microwell formats, and we provide proof-of-concept for its use in testing entry inhibitors and antiviral compounds.
Effects of Transgenic Rice Infected with SRBSDV on Bt expression and the Ecological Fitness of Non-vector Brown Planthopper Nilaparvata lugens
Authors: Xu Hong-Xing , He Xiao-Chan , Zheng Xu-Song , Zhou Xiao-Jun , Lin Yong-Jun , Lu Zhong-Xian 
Published: July 2017

AbstractThe susceptibility of rice lines, T1C-19, T2A-1, and MH63 to SRBSDV infection are similar and the contents of cry protein in T2A-1 and T1C-19 do not change significantly. The survival rates of BPH nymphs feeding on SRBSDV-infected T1C-19, Bt T2A-1, or MH63 rice plants were not significantly different. The developmental stages of female BPH fed on T1C-19 plants infected with SRBSDV were significantly shorter than those fed on uninfected rice, while the males showed no significant difference. The duration of BPH feeding on SRBSDV-infected T2A-1 and MH63 also showed no significant difference in comparison with the respective control groups. Longevities of BPH adults feeding on SRBSDV-infected T1C-19, T2A-1 or MH63 were also not significant. However, the longevity of male adult BPH feeding on un-infected MH63 was significantly reduced in comparison with that of adult males feeding on un-infected T1C-19 and T2A-1 rice. In addition, the different rice lines and the rice plants infected and uninfected with SRBSDV did not significantly affect the sex ratio, female body weight, longevity, fecundity, or egg hatchability of BPH. In general, transgenic Bt rice infected with SRBSDV had little effect on the ecological adaptability of BPH.
Dendritic optical antennas: scattering properties and fluorescence enhancement
Authors: Guo Ke , Antoncecchi Alessandro , Zheng Xuezhi , Sallam Mai , Soliman Ezzeldin A. , Vandenbosch Guy A. E. , Moshchalkov Victor. V. , Koenderink A. Femius 
Published: July 2017

AbstractWith the development of nanotechnologies, researchers have brought the concept of antenna to the optical regime for manipulation of nano-scaled light matter interactions. Most optical nanoantennas optimize optical function, but are not electrically connected. In order to realize functions that require electrical addressing, optical nanoantennas that are electrically continuous are desirable. In this article, we study the optical response of a type of electrically connected nanoantennas, which we propose to call “dendritic” antennas. While they are connected, they follow similar antenna hybridization trends to unconnected plasmon phased array antennas. The optical resonances supported by this type of nanoantennas are mapped both experimentally and theoretically to unravel their optical response. Photoluminescence measurements indicate a potential Purcell enhancement of more than a factor of 58.
Escape from humoral immunity is associated with treatment failure in HIV-1-infected patients receiving long-term antiretroviral therapy
Authors: Ouyang Yabo , Yin Qianqian , Li Wei , Li Zhenpeng , Kong Desheng , Wu Yanling , Hong Kunxue , Xing Hui , Shao Yiming , Jiang Shibo , Ying Tianlei , Ma Liying 
Published: July 2017

AbstractInterindividual heterogeneity in the disease progression of HIV-1-infected patients receiving long-term antiretroviral therapy suggests that some host-related factors may have limited treatment efficacy. To understand the nature of factors contributing to treatment failure, we performed a retrospective cohort study of 45 chronically HIV-1-infected individuals sharing a similar demographics and route of infection, compared the differences between virologically suppressed (VS) and treatment failure (TF) patients with respect to clinical, immunological and virological characteristics. We found that the baseline diversity of HIV-1 env quasispecies was the major difference between VS and TF group, and higher baseline diversity in TF patients. We further predicted TF-related env mutations using a selection pressure-based approach, followed by an analysis of these mutations based on the available three-dimensional structures of gp120/gp41 or their complexes with neutralizing antibodies. Notably, almost all of the identified residues could be mapped to the epitopes of known HIV-1 neutralizing antibodies, especially the epitopes of broadly neutralizing antibodies, and these mutations tended to compromise antibody-antigen interactions. These results indicate that the escape of HIV-1 from host humoral immunity may play a direct role in TF in long-term antiretroviral-experienced patients and that based on env gene sequence of the viruses in the patients.
Sugar intake from sweet food and beverages, common mental disorder and depression: prospective findings from the Whitehall II study
Authors: Knüppel Anika , Shipley Martin J. , Llewellyn Clare H. , Brunner Eric J. 
Published: July 2017

AbstractIntake of sweet food, beverages and added sugars has been linked with depressive symptoms in several populations. Aim of this study was to investigate systematically cross-sectional and prospective associations between sweet food/beverage intake, common mental disorder (CMD) and depression and to examine the role of reverse causation (influence of mood on intake) as potential explanation for the observed linkage. We analysed repeated measures (23,245 person-observations) from the Whitehall II study using random effects regression. Diet was assessed using food frequency questionnaires, mood using validated questionnaires. Cross-sectional analyses showed positive associations. In prospective analyses, men in the highest tertile of sugar intake from sweet food/beverages had a 23% increased odds of incident CMD after 5 years (95% CI: 1.02, 1.48) independent of health behaviours, socio-demographic and diet-related factors, adiposity and other diseases. The odds of recurrent depression were increased in the highest tertile for both sexes, but not statistically significant when diet-related factors were included in the model (OR 1.47; 95% CI: 0.98, 2.22). Neither CMD nor depression predicted intake changes. Our research confirms an adverse effect of sugar intake from sweet food/beverage on long-term psychological health and suggests that lower intake of sugar may be associated with better psychological health.
Obesity, adipokines, and C-peptide are associated with distinct plasma phospholipid profiles in adult males, an untargeted lipidomic approach
Authors: Pickens C. Austin , Vazquez Ana I. , Jones A. Daniel , Fenton Jenifer I. 
Published: July 2017

AbstractObesity is associated with dysregulated lipid metabolism and adipokine secretion. Our group has previously reported obesity and adipokines are associated with % total fatty acid (FA) differences in plasma phospholipids. The objective of our current study was to identify in which complex lipid species (i.e., phosphatidylcholine, sphingolipids, etc) these FA differences occur. Plasma lipidomic profiling (n = 126, >95% Caucasian, 48–65 years) was performed using chromatographic separation and high resolution tandem mass spectrometry. The responses used in the statistical analyses were body mass index (BMI), waist circumference (WC), serum adipokines, cytokines, and a glycemic marker. High-dimensional statistical analyses were performed, all models were adjusted for age and smoking, and p-values were adjusted for false discovery. In Bayesian models, the lipidomic profiles (over 1,700 lipids) accounted for >60% of the inter-individual variation of BMI, WC, and leptin in our population. Across statistical analyses, we report 51 individual plasma lipids were significantly associated with obesity. Obesity was inversely associated lysophospholipids and ether linked phosphatidylcholines. In addition, we identify several unreported lipids associated with obesity that are not present in lipid databases. Taken together, these results provide new insights into the underlying biology associated with obesity and reveal new potential pathways for therapeutic targeting.