bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult with autism – oxidative stress, co-morbidity and predisposition
Authors: Bækgaard Thorsen M. , Bilenberg N. , Munk-Jørgensen P. , Fex Svenningsen Å. , Heegaard N. , Maria Michel T. 
Published: June 2017

IntroductionThe etiology of autism spectrum disorder (ASD) is unclear. Studies involving children with ASD suggest that oxidative stress could explain some of the pathology. Few reports have investigated the role of oxidative stress into adulthood. Furthermore, the knowledge on psychiatric and somatic comorbidities, as well as socio-economic status in a trajectory across lifespan is sparse.ObjectivesInvestigating oxidative stress related markers in ASD, along with trajectories in socio-economic functioning and comorbidities.AimsTo evaluate the importance of oxidative stress in the neurobiology of adults with ASD and assess the socio-economic level of functioning and comorbidities.MethodsPlasma levels of antioxidant super-oxide-dismutase isoenzymes (SOD1 and SOD2) and pro-oxidant xanthineoxidase (XO) were measured in 56 patients ≥18 years of age, diagnosed in childhood with ASD (F84.0, F84.1, F84.5 or F84.8), along with gender and age matched controls. Participants were interviewed regarding their health, familial predisposition and social status.ResultsCases showed higher levels of SOD1 (268.2 ng/mL vs. 205.6 ng/mL). We found no differences regarding SOD2 and XO. Patients had a higher BMI (27 vs. 24), fewer drank alcohol (40% vs. 75%), more had a psychiatric co-morbidity (50% vs. 2%), more had family member with a psychiatric diagnosis (80% vs. 50%). None of the bio-psycho-social factors showed association with biomarker levels.ConclusionOxidative stress seems to play a role in ASD. Furthermore, patients with ASD often have psychiatric comorbidities; more often have a family history of psychiatric diagnoses, and are less healthy physically.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Genetic determinants of psychic resilience after a diagnosis of cancer
Authors: Christensen M. , Drago A. 
Published: June 2017

IntroductionCo-morbidity between cancer and psychiatric disorders including adjustment disorder, depressive disorders or angst can seriously influence the prognosis and the quality of life of patients.AimThe identification of the psychological and biological profile of patients at risk for such co-morbidity is not yet available. Classical candidate genes such as the BDNF, the 5-HTLPR and genes whose products are involved in inflammatory events have received some attention, but results are inconclusive.Object and methodsIn the present review the association between cancer and psychiatric disorders is reviewed, a focus on the investigation of the Gene X environment and the epigenetic control over the activation of the HPA axis is proposed as a tool to refine the definition of the biologic profile at risk for co-morbidity between psychiatry and cancer.Results and conclusionA number of genes and socio-demographic variables that may influence risk to suffer from a psychiatric disorder after a diagnosis of cancer is identified and discussed. The identification of such biologic and socio-demographic profile is instrumental in the identification of subjects at risk of a double diagnosis, both somatic and psychiatric. An early identification of such profile risk would pave the way to the implementation of early intervention strategies.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Is 22q11.2 deletion syndrome a genetic subtype of schizophrenia?
Authors: Hernandez Anton R. , Red Gallego H. De La , Gomez Garcia M. , Alonso Sanchez A. , Mayor Toranzo E. , Blanco Garrote J.A. , De Lorenzo Calzon M. , Hernandez Garcia M. , Dominguez E. , De Cegama F. Uribe Ladron , Molina Rodriguez V. 
Published: June 2017

Introduction22q11.2 deletion syndrome is a primary immunodeficiency due to micro-deletion on the large arm of chromosome 22. Patients suffer from several anomalies, including metal illness, that such the case we present, mean a warning sign for further study.MethodsTwenty-one years-old male, with psychotic symptoms, typical of schizophrenia, behavioral disorders and mental confusion, plus epileptic episodes and psychomotor agitation. Two previous incomes with the diagnosis of psychotic disorder not otherwise specified. Treated with anti-psychotics at low doses with inter-episode stability.BackgroundPrematurity, low birth weight, neonatal asphyxia, generalized seizures, otitis and recurrent urinary tract infections, hypernasal voice, poor academic performance, difficulty relating. Physical examination: hypernasal voice, furred tongue, dysmorphic faces, scoliosis, hipotanía, stereotypes, delusions, auditory hallucinationsd negative symptoms.ResultsWe considered the possibility of a neurodevelopmental disorder, with a multidisciplinary approach, resulting in the diagnosis of paranoid schizophrenia and velocardiofacial syndrome, which had gone unnoticed. Mean doses of clozapine, haloperidol and topiramate were used. He accepted psychiatry and other specialties follow-up, since it requires a complex and multidisciplinary approach.ConclusionsDefinition of velocardiofacial Syndrome and lack of consensus on terminology:– syndrome 22q11.2 DS as genetic subtype of schizophrenia? Opportunity to study the pathogenesis of schizophrenia;– the importance of a comprehensive approach to early diagnosis, clinical improvement and preventing complications.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Does the Use of Psychotropic Medication go up During Focused Efforts to Bring Coercion and Restraint Down?
Authors: Højlund M. , Høgh L. , Munk-Jørgensen P. , Stenager E. 
Published: June 2017

IntroductionAntipsychotic or anxiolytic medicine is widely used in agitated patients in risk of coercion. However this medication is also known to contribute to cardio-vascular disease and reduced life expectancy. Department of Psychiatry in Aabenraa, Denmark participates in a nation-wide Danish project supporting efforts to reduce coercion and restraint. Our hypothesis is that reduction of coercion might lead to unwanted increase in doses of psychotropic medication.ObjectiveTo document the use of psychotropic medication during the project period, in order to learn more about the impact of interventions to reduce coercion and restraint on psychopharmacological treatment.AimTo compare type and doses of psychotropic prescriptions during the project period with the time before implementation.MethodsCohort study of patients in risk of agitation and coercion admitted to the wards during first quarter of 2013 and 2016. Eligible patients were diagnosed as having organic mental disorders, substance abuse, psychotic disorders, mania, bipolar affective disease or personality disorders (ICD-10: F0x, F1x, F2x, F30-31, F60). Primary outcome is the exposure to antipsychotic medication measured as defined daily doses, and secondary outcomes are exposure to benzodiazepines, polypharmacy and compliance with guidelines on agitated patients.ResultsData collection is carried out during autumn of 2016, and the results will be presented at the congress.ConclusionsResults from this study will contribute to our understanding of the implications of the initiative to reduce restraint and coercion in psychiatry. The results will also sharpen our awareness of possible inexpedient practice.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Microanalysis: The Ethical Minefield
Authors: Nagpal R. , Mital A.K. 
Published: June 2017

Mental health professionals had always yearned for an intervention, which was restricted to them alone, was safe and had a commercial potential. Narco analysis or chemical hypnosis with or without the supervision of an anesthetist presented such an opportunity in India's largely poorly regulated medical practice. The turning point however was the unrestricted use of narco analysis for forensic reasons often against the will of the recipient that caught the attention of the judiciary. Professionals in candid confessions spoke of the tool replacing normal polite enquiries and unnecessary voyeuristic information being fettered out. Anecdotal evidence suggested police resorting to this tool without client consent or judicial permission. A series of fiats after searching enquiry on the statute has led to complete disarray. The legal issues have relegated the ethical issues of consent, the usefulness of “forced” information, the aftermath of “forced” information to the backburner. Currently, the tool is regulated by the judiciary and selectively applied with consent. In the clinical setting, it is fast disappearing.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Access to Mental Health Services Among Internally Displaced Persons in Ukraine: Results from a Nationwide Survey
Authors: Roberts B. , Makhashvili N. , Javakhishvili J. 
Published: June 2017

BackgroundThere are an estimated 1.4 million internally displaced persons (IDPs) in Ukraine as a result of the armed conflict in Ukraine.Objectives(i) Measure the burden of key mental disorders (PTSD, depression and anxiety); (ii) examine rates of utilization of health and psychosocial support services; (iii) examine the patterns of utilisation of services.MethodsThe study used a cross-sectional survey design and was conducted throughout Ukraine between March and May 2016 with 2203 IDPs aged 18 years and over. Time-location sampling was chosen as a probabilistic sampling method. Outcome measures were the PCL-5 for PTSD, the PHQ-9 for depression and the GAD-7 for anxiety. Descriptive and multivariate regression analyses were used.ResultsOf the 2203 respondents, 703 reported experiencing a mental health or emotional problem over the previous 12 months and were also screened positive with PTSD, depression or anxiety. Of these 703, 180 had sought care (with sources of care to be given in the presentation). Therefore, 523 respondents did not seek care, equating to an overall treatment gap of 74%, (74% for PTSD, 71% for depression and 70% for anxiety). Key reasons for not utilising treatment included preferring to use their own medications (n = 176); unaffordability of health services (n = 118) or medications (n = 140); poor understanding by health care providers (n = 123); poor quality of services (n = 78) and stigma/embarrassment (n = 41).ConclusionsThe findings support the need for a scaled-up, comprehensive and trauma informed response to provision of the mental health care of IDPs in Ukraine.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Fit Note Use in UK Clinical Practice 2010–2016: A Systematic Review of Quantitative Research
Authors: Dorrington S. , Roberts E. , Hatch S. , Madan I. , Hotopf M. 
Published: June 2017

BackgroundThe fit note, introduced in England, Wales and Scotland in 2010, was designed to radically change the sickness certification process from advising on individuals’ inability to work to what they could do if adjustments were made available. Our review aimed to evaluate: (1) the percentage of fit notes utilizing the new “may be fit for work” option or advising on work adjustments, (2) the impact of the fit note on sickness absence and return to work, (3) demographic variation in fit note use.MethodsWe systematically searched in Embase, Cochrane CENTRAL, Pub Med, Worldcat, Ovid and PsychInfo from 1 Jan 2010–30 Nov 2016 for studies on working aged adults which included the search terms “fit note” or “fitnote”. Relevant abstracts were extracted and we assessed the quality of the papers and assessed bias using the modified Newcastle Ottawa Scale.ResultsNine papers met the inclusion criteria, four of which were based on the same cohort. Maybe fit notes made up just 6.6% of all fit notes. Work adjustments were most often recommended for patients who were less deprived, female and patients with physical health problems. Fit note advice for patients with physical health problems increased over time, but the opposite was seen for patients with mental health problems.ConclusionsFurther research needed to evaluate the use, impact and potential of the fit note, especially for patients with mental illness.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Connection Between Coping Strategies and Quality of Life in Outpatient with Depression – Cross-sectional Study
Authors: Holubova M. , Prasko J. 
Published: June 2017

BackgroundThe quality of life is a multidimensional phenomenon which represents all aspects of patient's well-being and various areas of the patient's life. Specific coping strategies may be connected with the quality of life and also with the severity of the disorder. The objective of this study was to explore the relationship between the coping strategies and quality of life in outpatients with depressive disorder.MethodsEighty-two outpatients, who met ICD-10 criteria for depressive disorders, were enrolled in the cross-sectional study. Data on sociodemographic and clinical variables were recorded. Individuals with depression filled out the standardized measures: The Stress Coping Style Questionnaire (SVF-78), The Quality of Life Satisfaction and Enjoyment Questionnaire (Q-LES-Q), and The Clinical Global Impression (CGI).ResultsThe patients overuse negative coping strategies, especially, escape tendency and resignation. Using of positive coping is in average level (the strategy Positive self-instruction is little used). Coping strategies are significantly associated with quality of life. Higher using of positive coping has a positive association with QoL. The main factors related to QoL are the subjective severity of the disorder, employment and positive coping strategies according to regression analysis.ConclusionsThis study revealed the connection between coping strategies and quality of life in patients with depressive disorders. Strengthening the use of positive coping strategies may have a positive effect on the quality of life, mental conditions and treatment of patients with depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Features of Formation and System of Psychoprophylaxis of Suicidal Behavior in Young Patients with Depression
Authors: Kozhyna H. , Mykhaylov V. , Zelenskay K. 
Published: June 2017

The work covers the study of the formation of suicidal behavior in young adults with depressive disorders and developing of pathogenetic based system of its prevention. There were clinical and psychopathological signs of depressive disorders in young patients analyzed. Anxiety, asthenia, asthenic-apathetic and melancholy variants of depressive disorders in young patients with suicidal behavior were highlighted. In this study, there were the markers of suicide risk for young patients with depressive disorders determined: high suicide risk, low death self-consciousness, high anhedonia level, clinical manifestations of anxiety and depression by the hospital anxiety and depression scale, severe anxiety and depression by the Hamilton anxiety rating scale, major depressive episode by the Montgomery-Asberg depression rating scale. It has been proved that in observed young patients with depressive disorders with suicide behavior increased concentrations of serotonin, cortisol, noradrenaline and decreased levels of adrenaline and melatonine in plasma were observed. These changes were determined as neurohormonal background for depletion of adaptation resource in stress situations. There were approaches to differentiated prevention of suicidal behavior in depressive disorders in young people validated that include pharmacotherapy (selective SSRI, melatonin, serotonin and norepinephrine), psychotherapy and psychoeducation. Psychotherapeutic complexin patients with depressive episode must include personality-oriented psychotherapy, cognitive behavioral therapy, family therapy and autogenous training; in disorders of adaptation – rational psychotherapy, cognitive-behavioral analytic psychotherapy, family therapy, autogenic training. Psychoeducation should be carried out using information modules, training a positive self-image, improved compliance; formation of communication skills, problem solving, interpersonal interaction and problem-oriented discussions.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Cognitive Function Before and After Electroconvulsive Therapy in Patients with Major Depression
Authors: Tmava A. , Eicher I. , Seitz D.E. , Mörkl S. , Blesl C. , Wurm W. , Ebner C. , Painold A. , Holl A. 
Published: June 2017

BackgroundDespite its high effectiveness, electroconvulsive therapy (ECT) is not a widely used method to treat depression. One of the reasons for this could be the fear of cognitive side effects. The aim of this study was to investigate effects of ECT on cognitive function.MethodsWe conducted a prospective study with a sample size of 23 patients (10 male), who met the criteria of treatment-resistant depression according to ICD–10 and gave their informed consent for ECT treatment. Before and after ECT, the following investigations have been performed: Beck depression inventory (BDI), Montgomery-Asberg depression rating scale (MADRS), Mehrfachwahl-Wortschatz-Intelligenztest (MWT-B), trail making test (TMT) A and B, stroop-test, mini mental state examination (MMSE) and the German version of the California verbal learning test (MGT).ResultsAfter ECT treatment, we found highly significant changes of depression-scales BDI (P = 0.028) and MADR-Scale (P = 0.001). IQ as measured by the MWT-B (P = 0.851), executive functions as measured by trail making test A (P = 0.568) and B (P = 0.372) and stroop-test, memory functions as measured by the MGT (P = 0.565) (Figure 1) and MMSE (P = 0.678) did not differ significantly after ECT treatment.ConclusionThere were no significant differences in cognitive function before and after ECT treatment. To confirm these findings, it would be necessary to perform larger studies.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Substance use Disorder in the Offspring of Antenatally Depressed Mothers in the Northern Finland 1966 Birth Cohort: Relationship to Parental History of Severe Mental Disorder
Authors: Mäki P. , Taka-Eilola T. , Veijola J. 
Published: June 2017

IntroductionMaternal depression during pregnancy is common. However, reports of the adult offspring with maternal antenatal depression are scarce.ObjectivesOur aim was to study whether offspring of antenatally depressed mothers have increased risk for substance use disorder when taking account parental mental disorder.MethodsIn the Northern Finland 1966 Birth Cohort, the mothers of 12,058 children were asked at the antenatal clinic if they felt depressed. The offspring were followed for over 40 years. Substance use disorders were detected using the Finnish Care Register for Health Care, which was also used for identifying severe mental disorders in the parents till 1984.ResultsOf the mothers, 14% had rated themselves as depressed during pregnancy. Of the parents, 10% had had a hospital-treated mental disorder. The risk for substance use disorder was slightly increased in the offspring of antenatally depressed mothers (crude OR 1.6; 95% CI 1.2–2.1), when compared with the cohort members without maternal antenatal depression. The risk for substance use disorder was higher in the offspring with both maternal antenatal depression and parental mental disorder (2.8; 1.7–4.7) than in those with maternal depression but without parental mental disorder (1.4; 1.1–2.0) or those without maternal depression and with parental mental disorder (1.5; 1.1–2.2). The reference group was cohort members without maternal antenatal depression and without parental mental disorder. The association remained significant after adjustment [1].ConclusionsOffspring with both maternal depression during pregnancy and parental severe mental disorder have elevated risk for substance use disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.
A Study of Patient's Perspective of Schizophrenia Using Emic Perspective
Authors: Sanyal D. , Das D. 
Published: June 2017

IntroductionKnowledge about how patients perceive mental illness and how it possibly influences help seeking behaviour is important in development of proper plan for mental health reform.ObjectiveThis study planned to study disease related perception, first help seeking behaviour and stigma among schizophrenia patients admitted at a hospital.Aims(1) To know about patient's view regarding the problems; (2) attempt to predict help seeking behaviour.MethodsFifty-one patients suffering from schizophrenia according to DSM-5 and fit to be interviewed were assessed using EMIC (Explanatory Model Interview Catalogue) to get emic (insider or person's own cultural) perspective of disease related perception, help seeking behaviour and stigma.ResultsTerms used to describe their illness included “depression” (21.6%), “mental” (17.6%) “matha kharap” (9.8%). Most common perceived cause was stress (25.5%) and sorcery (23.5). Mental health specialist was visited by 27.5% Faith healer consultation was high (29.4%). Stigma score was higher with marriage related issues and social isolation. Using exhaustive CHAID analysis, it was found that patients with negative themes as disease name like “matha kharap” (loosely meaning crazy) are more likely to visit faith healers, while patients naming the condition with some medical related term like depression were more likely to visit mental health specialist.ConclusionClearly perception of patients regarding mental illness and its causation varies greatly from the way psychiatrists’ viewpoint and this perception is likely to influence help seeking behaviour. Understanding these issues is likely to enable better patient awareness and proper formulation of plans to address mental health issues.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Validation of the Arabic Version of the Oxford Happiness Inventory Among Undergraduates in Kuwait
Authors: Alansari B. , AlAli T. 
Published: June 2017

IntroductionThe Oxford Happiness Inventory (OHI) 29-Item, each involving the selection of four options that are different for each item. Although there is an Arabic version, it is not identical to the original version in terms of the number of items and response.Objectivesto evaluate the psychometric properties of the Arabic adaptation OHI and its factorial structure in undergraduate sample.MethodsThe participants were 720 first year undergraduate Kuwaitis: 360 males mean age = 20.38 ± 1.60 and 360 females; mean age = 19.71 ± 1.39 (t = 5.87, P < 0.001). The Arabic version of OHI (Argyle, Martin, & Crossland) was administered to participants. The internal consistency reliability, factor structure, and convergent validity of the OHI with Life Orientation Test (LOT-R, Adult Hope Scale (AHS), Satisfaction With Life Scale (SWLS) were assessed as well as divergent validity of the OHI with Beck Depression Inventory-II (BDI-II)ResultsInternal consistency was satisfactory for the OHI (Cronbach's alpha = 0.87) for males and (Cronbach's alpha = 0.86) for females. The results revealed no significant gender differences on happiness (F = 1.77, P > 05). Principal component analyses (PCA) showed that a seven-component solution explains %50.50 of the total variance for males and 51.47% for females. The OHI positively correlates with the following variables: SWLS (r = .52), LOT-R (r = 0.56) AHS (r = .48) while the OHI correlates negatively with BDI-II (r = -54).ConclusionsFindings confirm that the OHI provides satisfactory validation, and thus it can be recommended as a measure of happiness among Arab samples.Disclosure of interestThe authors have not supplied their declaration of competing interest.