bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of carotid ultrasound screening in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study
Authors: Bryce Yolanda , Whitton Jillian A. , Stratton Kayla L. , Leisenring Wendy M. , Chow Eric J. , Armstrong Gregory , Weil Brent , Dieffenbach Bryan , Howell Rebecca M. , Oeffinger Kevin C. , Nathan Paul C. , Tonorezos Emily S. 
Published: October 2024

AbstractIntroductionMany childhood cancer survivors are at risk for cardiovascular disease and stroke. The North American Children's Oncology Group long‐term follow‐up guidelines recommend carotid ultrasound in cancer survivors 10 years after neck radiation therapy (RT) ≥40 Gy. The use of carotid ultrasound in this population has not been described.MethodsSurvivors of childhood cancer diagnosed 1970‐1999 (N = 8693) and siblings (N = 1989) enrolled in the Childhood Cancer Survivor Study were asked if they had ever had a carotid ultrasound. Prevalence of carotid ultrasound was evaluated. Prevalence ratios (PR) and 95% confidence intervals (CIs) were evaluated in multivariate Poisson regression models.ResultsAmong participants with no reported cardiovascular condition, prevalence of carotid ultrasound among survivors with RT ≥40 Gy to the neck (N = 172) was 29.7% (95% CI, 22.5–36.8), significantly higher than those with <40 Gy (prevalence 10.7%; 95% CI, 9.9%–11.4%). Siblings without a cardiovascular condition (N = 1621) had the lowest prevalence of carotid ultrasound (4.7%; 95% CI, 3.6%–5.7%). In a multivariable models among survivors with no reported cardiovascular condition and RT ≥40 Gy to the neck, those who were over age 50 (vs. 18–49) at follow‐up (PR = 1.82; 95% CI, 1.09–3.05), with a history of seeing a cancer specialist in the last 2 years (PR = 2.58; 95% CI, 1.53–4.33), or having a colonoscopy (PR = 2.02; 95% CI, 1.17–3.48) or echocardiogram (PR = 6.42; 95% CI, 1.54–26.85) were more likely to have had a carotid ultrasound.ConclusionMany survivors do not undergo carotid ultrasound despite meeting existing guidelines. Health care delivery features such as having seen a cancer specialist or having other testing are relevant.
In Situ Preparation of Highly Active and Selective Fe‐MOF/V–C3N4 for Photocatalytic Hydroxylation of Benzene to Phenol
Authors: Jia Xu , Qiao Jiaolong , Xu Xuetong , Liu Cong , Zhang Liuxue , Liu Mengge , Zhang Huiqin , Li Wenzhuo , Jiao Shuyan , Wang Xiulian 
Published: October 2024

AbstractThe selective photocatalytic oxidation of benzene to phenol under mild conditions is of great significance for the next‐generation phenol industry. In order to improve the efficiency of the phenol production process, a heterojunction catalyst based on Fe‐MOF/V–C3N4 was synthesized by solvothermal method. Compared with Fe‐MOF and C3N4, the photogenerated charge separation rate of this composite catalyst was significantly enhanced, and the photogenerated electron‐hole complexation was significantly weakened.Under the optimal conditions, the yield and selectivity of phenol were 18.75 % and 96 % respectively, and the photocatalytic activity remained high after four reaction cycles. The improved strategy for this catalyst will provide some new insights for the development of more efficient photocatalysts for the direct hydroxylation of benzene to phenol.
Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Recombinant Neorudin, a New Anticoagulant Drug in Patients With Acute Coronary Syndrome
Authors: Liu Yu‐bin , Liang Yan , Liu Hui‐chen , Feng Guang‐xun , Zhou Xing‐chen , Zhang Lin , Zhang Xiao‐long , Li Qiang , Ren Bo‐yuan , Xia Xia , Zhu Jun , Wu Chu‐tse , Jin Ji‐de 
Published: October 2024

AbstractThis study evaluated the safety, tolerability, pharmacodynamics, and pharmacokinetics of recombinant neorudin (EPR‐hirudin [EH]) in patients with acute coronary syndrome (ACS), providing a basis for further therapeutic research. This open‐label, single‐center, nonrandomized, nonblinded, and noncontrolled trial categorized 24 patients with nonprogressive ACS who met the screening criteria into 3 groups. They received an intravenous injection of neorudin (0.4 mg/kg), followed by an intravenous drip at doses of 0.15, 0.30, and 0.45 mg/kg/h for 3 days in the low‐, medium‐, and high‐dose groups, respectively. The safety, tolerability, pharmacodynamics, and pharmacokinetics of EH were assessed after treatment, indicating that neorudin was safe and well tolerated in nonprogressive ACS. No serious adverse events or clinical composite end points were observed. The activated partial thromboplastin time and thrombin time increased significantly and dose dependently following EH administration across all groups compared to pretreatment values. Conversely, thrombin activity significantly decreased after drug administration but returned to baseline levels shortly after drug withdrawal. Within the administered dose range, neorudin exposure increased with the dose, and its half‐life was approximately 2 hours. Neorudin was found to be safe and tolerable for treating patients with nonprogressive ACS, demonstrating therapeutic efficacy at doses up to 0.45 mg/kg/h over a 3‐day period.
Conformational and Solvent Effects on the Photoinduced Electron Transfer Dynamics of a Zinc Phthalocyanine–Benzoperylenetriimide Conjugate: A Nonadiabatic Dynamics Simulation
Authors: Liu Sha‐Sha , Wei Xin , Zheng Yan , Liu Shuai , Xu Dong‐Hui , Li Laicai , Cui Ganglong , Liu Xiang‐Yang 
Published: October 2024

AbstractHerein, we employed a combination of static electronic structure calculations and nonadiabatic dynamics simulations at linear‐response time dependent density functional theory (LR‐TDDFT) level with the optimally tuned range‐separated hybrid (OT‐RSH) functional to explore the ultrafast photoinduced dynamics of a zinc phthalocyanine‐benzoperylenetriimide (ZnPc‐BPTI) conjugate. Due to the flexibility of the linker, we identified two major conformations: the stacked conformation (ZnPc‐BPTI‐1) and the extended conformation (ZnPc‐BPTI‐2). Since the charge transfer states are much lower than the lowest local excitation in ZnPc‐BPTI‐1, which is contrary to ZnPc‐BPTI‐2, the ultrafast electron transfer (~3.6 ps) is only observed in the nonadiabatic simulations of ZnPc‐BPTI‐1 upon local excitation around the absorption maximum of ZnPc. However, when considering the solvent effects in benzonitrile: the lowest S1 states are both charge transfer states from ZnPc to BPTI for different conformers. Subsequent nonadiabatic dynamics simulations indicate that both conformers experience ultrafast electron transfer in benzonitrile with two time constants of 90 [100] fs and 1.40 [1.43] ps. Our present work not only agrees well with previous experimental study, but also points out the important role of conformational changes and solvent effects in regulating the photodynamics of organic donor‐acceptor conjugates.
Stoichiometric‐Ratio‐Controlled Fe and Ni Non‐Noble Metal Catalysts Supported on γ‐Al2O3 for Turquoise Hydrogen and Carbon Nanotubes Production
Authors: Rajpoot Aakash , Ahmad Khan Afaq , Mohan Indra , Sengupta Siddhartha , Ahmad Ejaz 
Published: October 2024

AbstractHerein, we synthesized a series of catalysts comprising iron (Fe), and nickel (Ni) supported on γ‐Al2O3 nano‐powder (Fe−Ni/γ‐Al2O3) by controlling the stoichiometric ratio of the metals through the facile co‐precipitation method. The ratio of Fe and Ni on the γ‐Al2O3 support varied from 0 to 70 weight percent (wt %). The freshly prepared catalysts phase, structure, and crystallinity exhibited variability as the Fe and Ni stoichiometric ratios were altered. The catalyst demonstrated effective performance in methane cracking, producing turquoise hydrogen and carbon nanotubes (CNTs) using a temperature‐programmed reactor coupled with mass spectrometry. It was observed that the Fe3Ni4 catalyst, comprising 30 % Fe and 40 % Ni, exhibited a maximum methane conversion rate of 85 % and a hydrogen yield of 72.55 %. Moreover, the values of turnover frequency (2.38 min−1) indicated that the Fe3Ni4 had a better production rate and was consistent with the conversion process throughout the reaction. The structural attributes of the spent catalysts were examined, revealing variations in the lateral length, uniformity, and diameters (~33 to 56 nm) of the produced Carbon Nanotubes (CNTs) when transitioning from catalyst Fe0Ni7 to Fe7Ni0. The investigation underscored the significance of metal stoichiometrically controlled catalysts and their catalytic efficacy in methane cracking applications.
Orbital‐Driven Insights into Enantioselective Hydrofunctionalization of Alkenes Catalyzed by Co‐Salen Complexes: Study on Singlet and Triplet States
Authors: Gupta Shivangi , Rawal Parveen , Gupta Puneet 
Published: October 2024

AbstractThe Co(salen) ([LCo(II)]) mediated hydrofunctionalization of alkenes is a highly significant method for forming enantioselective products. In this work, we conducted comprehensive computational investigations to gain insights of the reaction mechanism. The orbital analysis and intrinsic bond orbital analysis (IBO) were utilized to unravel the flow of electrons during the progress of the reaction. We explored various spin state surfaces to understand the possible pathways for the reaction. Initially, [LCo(II)] reacts with an oxidant tertbutyl peroxybenzoate, yielding [LCo(III)OC(O)Ph] and [LCo(III)OtBu]. Subsequently, [LCo(III)OC(O)Ph] reacts with silane to form cobalt hydride ([LCo(III)H]), with the triplet spin state surface being the preferred pathway, featuring an energy barrier of 14.2 kcal mol−1. IBO analysis across this step revealed that it involves the transfer of hydrogen as a hydride. Subsequently, the [LCo(III)H] complex in a triplet spin state undergoes a minimum energy crossing point (MECP) to transition into the singlet spin state, representing its most stable configuration. The [LCo(III)H] complex further reacts with styrene via hydrogen atom transfer on the singlet spin state surface, followed by oxidation and subsequent reaction with indole on the doublet spin surface to yield the hydrofunctionalized product. This work also explores potential enantioselective steps in the reaction.
TiO2 Surface Hybridisation with Ag and CuO for Solar‐Assisted Environmental Remediation and Sustainable Energy Applications
Authors: Dvoranová D. , Koci K. , Lajaunie L. , Edelmannova M. F. , Seabra M. P. , Brezová V. , Arenal R. , Labrincha J. A. , Tobaldi D. M. 
Published: October 2024

AbstractIndustrialisation has led to unprecedented levels of outdoor air pollution, posing a significant health risk to human beings. Consequently, there is an urgent need to replace fossil fuels with sustainable energy sources, thereby mitigating these risks and providing a safer outdoor and indoor environment. Titanium dioxide is a versatile transition metal oxide with applications ranging from energy conversion to environmental remediation. However, it faces limitations, particularly in its absorption spectrum and charge separation efficiency, and enhancing these properties remains a significant challenge. In this research work, we have decorated the surface of TiO2 hybridising it with noble‐metal and/or noble‐metal oxides (Ag and/or CuO) to improve the photocatalytic performances (monitoring the removal of nitrogen oxides and benzene, and hydrogen generation from water splitting) under simulated solar‐light irradiation. Our results showed that titania modified with an Ag : Cu molar ratio equal to 1 : 1, not only exhibited the most promising performance in terms of nitrogen oxides and benzene removal, it was the optimum amount for the light‐induced generation of hydrogen from water splitting.
Understanding the CSR‐luxury paradox: The duality of luxury and responsibility in consumer perceptions
Authors: Sun Yanqi , Mai Tianxiang , Xu Cheng 
Published: October 2024

AbstractThis article delves into the intricate dynamics between luxury businesses' environmental responsibility initiatives and consumer perceptions, grounded in the theory of reasoned action. Utilizing three experimental studies, this article explores the interplay of corporate social responsibility (CSR) message framing (responsibility‐focused vs. dignity‐focused) and the nature of the luxury business (established vs. entrepreneurial). Study 1 examines the interaction between luxury brand type and CSR message framing, revealing that responsibility‐focused narratives enhance consumer interest in entrepreneurial brands but not in established ones. Study 2 investigates the psychological mechanisms underlying these effects, finding that dignity‐focused narratives increase consumer engagement through perceived authenticity and alignment with self‐image. Study 3 employs longitudinal field research to track actual buying behaviors, showing that dignity‐focused messages significantly boost spending, brand loyalty, and satisfaction, particularly for entrepreneurial brands. The findings illuminate the nuanced consumer reactions to CSR initiatives, underscoring the importance of message framing and brand nature in shaping luxury consumption attitudes.
Stoichiometric Regeneration of Biomimetic Nicotinamide Coenzyme Powered by Biomass Sugars via In Vitro Synthetic Enzymatic Biosystems
Authors: Li Qiangzi , Su Hao , Meng Dongdong , Qin Yanmei , Wu Ranran , Zhu Zhiguang , Sheng Xiang , You Chun , Job Zhang Yi‐Heng P. 
Published: October 2024

AbstractBiomimetic nicotinamide coenzymes, including nicotinamide mononucleotide (NMN+), have been demonstrated as promising low‐cost alternatives to nicotinamide adenine dinucleotide (phosphate) (NAD(P)+) in biocatalysis. Herein, to efficiently regenerate NMNH from NMN+ in vitro powered by biomass sugars, a thermophilic NADP+‐dependent glucose 6‐phosphate dehydrogenase from Thermotoga maritima (TmG6PDH) was engineered to increase the activity toward NMN+. The catalytic efficiency (kcat/Km) of optimal mutant (TmG6PDH−R7) toward NMN+ increased by 71.7‐fold than TmG6PDH‐WT. As a result, compared to the wild type, the coenzyme specificity ([kcat/Km]NMN+/[kcat/Km]NADP+) of TmG6PDH−R7 increased by ~2.0×105‐fold. The structural analysis revealed that the introduced hydrophobic and bulky residues lead to the formation of a smaller binding pocket, which resulting in a higher affinity for NMN+ with small size than NADP+. Then several in vitro synthetic enzymatic biosystems (ivSEBs) comprising this thermophilic TmG6PDH−R7 and a previously engineered thermophilic 6‐phosphogluconate dehydrogenase were constructed. These ivSEBs harnessed the complete oxidation of renewable biomass sugars to facilitate the stoichiometric regeneration of 12 molecules of NMNH from 1 molecule of glucose, thereafter producing various products such as levodione, 2,3‐butanediol or bioelectricity, over a wide temperature range. This study could pave the way for using stable and low‐cost biomimetic coenzymes in ivSEBs for industrial biomanufacturing.
In‐Situ Preparation of Iron(II)‐phthalocyanine@multi‐Walled‐CNTs Nanocomposite for Quasi‐Solid‐State Flexible Symmetric Supercapacitors with Long Cycling Life
Authors: Lu Yongwang , Pang Xin , Li Minzhang , Liang Man , Wang Wei , He Qinyu , Qahramon Zarifzoda Afzalshoh , Chen Fuming 
Published: October 2024

AbstractThe construction of supercapacitor electrode materials with exceptional performance is crucial to the commercialisation of flexible supercapacitors. Here, a novel in‐situ precipitation technique was applied for constructing iron(II)‐phthalocyanine (FePc) based nanocomposite as the electrode material in quasi‐solid‐state flexible supercapacitors. The highly redox‐active FePc nanostructures were grown in the multi‐walled‐CNTs (MWCNTs) networks, which shows convenient electron/electrolyte ion transport pathways along with outstanding structural stability, leading to high energy storage and long cycling life. The electrode of FePc@MWCNTs delivered a higher specific capacity than that of individual MWCNTs and FePc. The quasi‐solid‐state symmetric flexible device that was constructed using FePc@MWCNTs electrode demonstrated impressive performance with a maximum energy density of 29.7 Wh kg−1 and a maximum power density of 4000 W kg−1. Moreover, the device demonstrated superior durability and flexibility, as evidenced by its exceptional cyclic stability (111.3 %) even after 30000 cycles at 8 A g−1. These results reveal that the FePc@MWCNTs nanocomposite prepared by this simple in‐situ precipitation method is promising as electrode material for next‐generation flexible wearable power sources.
Factors associated with knowledge in African immigrants with personal experiences of dementia
Authors: Nkimbeng Manka , Aswani Truphosa (Posa) , Albers Elle , Russell Wynfred N. , Shippee Tetyana P. , Gaugler Joseph E. 
Published: October 2024

AbstractINTRODUCTIONDementia literacy shapes understanding of care and caregiving and thus influences the health outcomes of the care partner and the person living with dementia.METHODSLinear regression models were used to identify factors associated with dementia knowledge among a cross‐sectional sample of African immigrants with personal experiences of dementia.RESULTSAmong 191 participants, the mean age was 36 (± 13.8) years, 64% were male, and 81% were care partners. Second‐generation African immigrants had statistically significant higher knowledge about dementia causes (4 ± 1.5 vs. 3.5 ± 1.6). Participants who would seek care at health organizations and community networks had higher dementia knowledge compared to those who would seek care at community networks alone (b: 1.23 95% confidence interval [0.25, 2.21]).DISCUSSIONWhere an African immigrant would seek care was associated with dementia knowledge. Thus, incorporating community care preferences and community‐based approaches into national programs such as the Healthy Brain Initiative, can enhance dementia outreach efforts.Highlights
Effective use of community engagement with Africans to explore current dementia knowledge.
Second‐generation African immigrants may have more dementia knowledge.
African immigrant caregivers may have more dementia knowledge.
African immigrants who seek community care only have limited dementia knowledge.
Shorter Migration Distance and Breeding Latitude Correlate With Earlier Egg‐Laying Across the Northeastern Pacific Ocean Range of the Rhinoceros Auklet (Cerorhinca monocerata)
Authors: Cross Cayle J. R. , Studholme Katharine R. , Drever Mark C. , Domalik Alice D. , Hipfner J. Mark , Crossin Glenn T. 
Published: October 2024

ABSTRACTModels of migratory behavior predict trade‐offs between fitness costs and benefits with respect to migration distance. Shorter migration distances may confer a fitness benefit by facilitating earlier breeding, however this is rarely investigated. We tested this hypothesis using a large‐scale geolocation (GLS) dataset from 109 rhinoceros auklets (Cerorhinca monocerata), a differentially migrating seabird, that was tagged at 12 breeding colonies along the Pacific Coast of North America, spanning southern California to the eastern Aleutian Islands, Alaska. Using GLS‐based position estimates, we determined the geographic centroid of the pelagic areas occupied by birds in winter (1 January–28 February) and then calculated the distance between their wintering centroids and colony of origin. We then used GLS light‐intensity and salt‐water immersion (wet/dry) data to determine each individual's date of egg‐laying the following spring. Rhinoceros auklets were very widely distributed across the northeastern Pacific Ocean in winter. Among all individuals, the distance between winter centroids and breeding colonies ranged from < 100 to > 2500 km, being greater among individuals originating from colonies at higher latitudes. As predicted, migration distance and colony latitude were positively related to lay date: after accounting for colony‐level differences in phenology, individuals that migrated shorter distances tended to lay their eggs earlier, a pattern that emerged across all populations. Our study links the migration distance of rhinoceros auklets to a fitness‐related outcome, underscoring the selective pressure that migration exerts on subsequent breeding activity.
Optimization of drawing sequence in longwall top coal caving mining through an FDM‐DEM model
Authors: Huo Yuming , Wang Shaozhuo , Zhu Defu , Wang Zhonglun 
Published: October 2024

AbstractThe Longwall top coal caving (LTCC) technology is regarded as one of the most crucial approaches for exploiting thick coal seams. A crucial and effective approach for improving the recovery rate of top coal and reducing coal resource losses in LTCC faces is to reasonably select process parameters based on actual mining and geological conditions of different mines. The main focus of this paper is the engineering background of the 12,309 LTCC face in Wangjialing Coal Mine. A numerical model is developed using FALC3D and PFC3D software, employing a finite difference method and discrete element method. This model takes into account predetermined cutting and caving ratios, as well as drawing intervals. To examine the caving process and roof particles, three different drawing sequences were examined: sequential drawing, segmented sequential drawing, and intermittent drawing. The findings suggest that, in terms of the reset shape of the drawing body before individual and entire caving, the segmented sequential drawing method exhibits noticeable drawbacks compared to the other two methods. From the perspective of the drawing weight, following “closing drawing opening when seeing gangue”, the sequential drawing, segmented sequential drawing, and intermittent drawing methods can yield 32.42 t, 26.87 t, and 35.78 t of top coal, with corresponding recovery rates of 73.39%, 60.81%, and 82.97%. Therefore, it can be concluded that intermittent drawing is suitable for implementation on LTCC working face 12,309.
Application of Multivariate Data Analysis Methods for Rapid Detection and Quantification of Adulterants in Lavender Essential Oil Using Infrared Spectroscopy
Authors: El Mrabet Abdennacer , El Orche Aimen , Diane Abderrahim , Alami Lamiae , Said Amal Ait Haj , Bouatia Mustapha , El Otmani Ibrahim Sbai 
Published: October 2024

ABSTRACTLavender, widely cultivated in the Mediterranean region, produces essential oil known for its significant biological activities and is a key component of the perfume industry due to its high levels of Linalool and Linalyl acetate, along with low Camphor content, which contributes to its high cost. However, the market is plagued by adulterated lavender oil, often mixed with cheaper alternatives such as eucalyptus and rosemary. Current detection methods, primarily gas chromatography, are expensive, time‐consuming and often fail to detect low levels of adulteration. To address these limitations, this study examines the use of mid‐infrared spectroscopy for the detection and prediction of adulteration levels. A set of 105 samples, comprising pure lavender oil and adulterated lavender oil, was prepared in the laboratory. Principal component analysis (PCA), hierarchical clustering ascending (HCA) and K‐means clustering were applied to the FT‐MIR results for qualitative analysis to effectively discriminate between authentic and adulterated essential oils. For quantitative analysis, partial least squares regression (PLSR) was used to develop accurate calibration models for predicting the percentage of adulteration. The results from PCA, HCA and K‐means demonstrated the efficacy of these techniques in detecting adulteration, even at low levels (2%). Calibration models were developed using the PLSR method with different spectral preprocessing techniques to predict the percentage of adulteration, with results indicating that models generated on the raw data and those using MSC (multiplicative signal correction) pre‐processing are optimal. In addition, the use of interval‐partial least squares (IPLS) variable selection techniques (Forward, Backward) improved the predictive accuracy of the models developed by reducing the number of wavelengths used.