bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized Controlled Trial of Family Finding
Authors: Vandivere Sharon , Malm Karin E. , Allen Tiffany J. , Williams Sarah Catherine , McKlindon Amy 
Published: February 2017

Background: Youth who have experienced foster care are at risk of negative outcomes in adulthood. The family finding model aims to promote more positive outcomes by finding and engaging relatives of children in foster care in order to provide options for legal and emotional permanency. Objectives: The present study tested whether family finding, as implemented in North Carolina from 2008 through 2011, improved child welfare outcomes for youth at risk of emancipating foster care without permanency. Research Design: A randomized controlled trial evaluation was carried out in nine counties in North Carolina. All children eligible for intervention services between 2008 and 2011 underwent random assignment. Effects were tested with an intent-to-treat design. Outcome data were obtained for all subjects from child welfare administrative data. Additional outcome data for a subset of older youth came from in-person interviews. Subjects: Subjects included 568 children who were in foster care, were 10–17 years old (at time of referral), had no identified permanent placement resource, and had no plan for reunification. Measures: The confirmatory outcome was moves to more family-like placements, whether through a step-down in foster care placement or discharge from foster care to legal permanency. Results: No impact on the confirmatory outcome was observed. Findings regarding exploratory impacts are also described; these must be interpreted with caution, given the large number of outcomes compared. Conclusions: The evaluation failed to find evidence that family finding improves the outcomes of older youth at risk of emancipation from foster care.
Characterization of the L-glutamate clearance pathways across the blood–brain barrier and the effect of astrocytes in an in vitro blood–brain barrier model
Authors: Helms Hans CC , Aldana Blanca I , Groth Simon , Jensen Morten M , Waagepetersen Helle S , Nielsen Carsten U , Brodin Birger 
Published: February 2017

The aim was to characterize the clearance pathways for L-glutamate from the brain interstitial fluid across the blood–brain barrier using a primary in vitro bovine endothelial/rat astrocyte co-culture. Transporter profiling was performed using uptake studies of radiolabeled L-glutamate with co-application of transporter inhibitors and competing amino acids. Endothelial abluminal L-glutamate uptake was almost abolished by co-application of an EAAT-1 specific inhibitor, whereas luminal uptake was inhibited by L-glutamate and L-aspartate (1 mM). L-glutamate uptake followed Michaelis–Menten-like kinetics with high and low affinity at the abluminal and luminal membrane, respectively. This indicated that L-glutamate is taken up via EAAT-1 at the abluminal membrane and exits at the luminal membrane via a low affinity glutamate/aspartate transporter. Metabolism of L-glutamate and transport of metabolites was examined using [U-13C] L-glutamate. Intact L-glutamate and metabolites derived from oxidative metabolism were transported through the endothelial cells. High amounts of L-glutamate-derived lactate in the luminal medium indicated cataplerosis via malic enzyme. Thus, L-glutamate can be transported intact from brain to blood via the concerted action of abluminal and luminal transport proteins, but the total brain clearance is highly dependent on metabolism in astrocytes and endothelial cells followed by transport of metabolites.
Interval cancers in a guaiac-based colorectal cancer screening programme: Consequences on sensitivity
Authors: Blom Johannes , Törnberg Sven 
Published: February 2017

Objective To evaluate interval cancers in the population-based colorectal cancer screening programme of Stockholm/Gotland, Sweden. Methods From 2008, individuals aged 60–69 were invited to colorectal cancer screening using biennial guaiac-based faecal occult blood test (Hemoccult®). Interval cancers, defined as colorectal cancer among participants not diagnosed by the screening programme but registered in the Swedish cancer register, were evaluated by cross-checking the screening histories for all cancers in the region 2008–2012. Results Of 203,848 individuals from nine different birth cohorts who participated (∼60%), 4530 (2.2%) tested positive. All invited individuals were followed up for 24 months after invitation. The cancer register reported 557 colorectal cancer, 219 (39.3%) screen-detected cancers and 338 (60.7%) interval cancers, generating both test- and episode sensitivities of approximately 40% and an interval cancer-rate of 17.1/10,000 tests. Among individuals with positive tests without colorectal cancer diagnosed at work-up colonoscopy, 37 interval cancers (10.9%) occurred. There was statistically significant lower sensitivity in women, ranging 22.4–32.2%, compared with 43.2–52.0% in men. Age-group and tumour location were not strongly correlated to screen-detected cancer rates. The programme sensitivity increased by year (20.3–25.0%), with successively more colorectal cancers diagnosed within the expanding programme (11.6–16.2%). Conclusion Interval cancer is a quality indicator of a screening programme. As the interval cancer-rate determined in a well-organized population-based screening programme was actually higher than the screen-detected cancer rate, a change to a more sensitive screening test is indicated. The lower screen-detected cancers among women, and compliance and quality of work-up colonoscopies also need attention.
The effect of inhibitory control and its training on L1 and a new learned language switching
Authors: Liu Huanhuan , Dunlap Susan , Liang Lijuan , Chen Baoguo 
Published: February 2017

Aims: This study aimed to investigate how individuals’ inhibitory control (IC) ability affects language switching in the initial period of language learning. Design: Using a pretest/posttest design and event-related potential (ERP) methodology, we investigated the effect of IC on Chinese–English bilinguals during their language switching between Chinese (L1) and Korean (a language new to the participants, Lnew). All participants were required to name pictures (picture-naming task) in their L1 and Lnew in the pretest and posttest. Low-IC participants received an IC task training between the pretest and the posttest, while the high-IC group did not. Data and analysis: Analyses of both response latencies and ERP data were conducted by repeated-measures ANOVA. Findings: Results showed that the high-IC group exhibited symmetrical switch costs in both the pretest and the posttest. Besides, a more obvious late positive component (LPC) was observed when the high-IC participants switched from L1 to Lnew than the other way around, indicating their ability to inhibit cross-language interference. In contrast, the low-IC group exhibited asymmetrical switch costs, and no amplitude difference when switching between Lnew and L1 in the pretest. However, in the posttest, the switch costs pattern and the LPC results of the low-IC group became similar to those of the high-IC group. Innovation: The present study was a first attempt to provide electrophysiological evidence that IC ability plays an important role during L1–Lnew switching. Significance: These findings support the hypothesis that individuals’ IC ability plays a role of suppressing the non-target lexical access during language switching in the initial period of second language learning. The results also indicate that the relevant training in IC ability could contribute to the improvement of the language-switching efficiency in the initial period of language learning.
Appraising the methodological quality of the clinical practice guideline for diabetes mellitus using the AGREE II instrument: a methodological evaluation
Authors: Radwan Mahmoud , Akbari Sari Ali , Rashidian Arash , Takian Amirhossein , Abou-Dagga Sanaa , Elsous Aymen 
Published: February 2017

Objectives To evaluate the methodological quality of the Palestinian Clinical Practice Guideline for Diabetes Mellitus using the Translated Arabic Version of the AGREE II. Design Methodological evaluation. A cross-cultural adaptation framework was followed to translate and develop a standardised Translated Arabic Version of the AGREE II. Setting Palestinian Primary Healthcare Centres. Participants Sixteen appraisers independently evaluated the Clinical Practice Guideline for Diabetes Mellitus using the Translated Arabic Version of the AGREE II. Main outcome measures Methodological quality of diabetic guideline. Results The Translated Arabic Version of the AGREE II showed an acceptable reliability and validity. Internal consistency ranged between 0.67 and 0.88 (Cronbach’s α). Intra-class coefficient among appraisers ranged between 0.56 and 0.88. The quality of this guideline is low. Both domains ‘Scope and Purpose’ and ‘Clarity of Presentation’ had the highest quality scores (66.7% and 61.5%, respectively), whereas the scores for ‘Applicability’, ‘Stakeholder Involvement’, ‘Rigour of Development’ and ‘Editorial Independence’ were the lowest (27%, 35%, 36.5%, and 40%, respectively). Conclusions The findings suggest that the quality of this Clinical Practice Guideline is disappointingly low. To improve the quality of current and future guidelines, the AGREE II instrument is extremely recommended to be incorporated as a gold standard for developing, evaluating or updating the Palestinian Clinical Practice Guidelines. Future guidelines can be improved by setting specific strategies to overcome implementation barriers with respect to economic considerations, engaging of all relevant end-users and patients, ensuring a rigorous methodology for searching, selecting and synthesising the evidences and recommendations, and addressing potential conflict of interests within the development group.
Epidemiology of surgically managed anterior cruciate ligament ruptures in a sports surgery practice
Authors: Sayampanathan Andrew Arjun , Howe Bryan Koh Thean , Bin Abd Razak Hamid Rahmatullah , Chi Chong Hwei , Tan Andrew Hwee Chye 
Published: February 2017

Introduction: Anterior cruciate ligament (ACL) tears are common knee injuries, especially among sportsmen and sportswomen. The aim of this study is to better understand the epidemiology of surgically managed ACL tears sustained in our institution. Methods: All patients who underwent arthroscopic ACL reconstruction by the senior author of this article in Singapore from 2008 to 2013 were studied. Patients who were diagnosed clinically and/or radiologically to have a complete tear of the ACL and subsequently underwent arthroscopic ACL reconstruction were included. Patients who suffered from traumatic knee dislocation were excluded. Two hundred and ninety-two patients were available for analysis. All patients were operated on by the senior author. Results: 83.9% of patients were male. 60.5, 23.0, 8.46, and 8.11% were of Chinese, Malay, Indian and other origins, respectively. 69.6 and 28.7% were in white-collared and blue-collared jobs, respectively, while 1.69% were unemployed. Mean age at operation was 29.4 years. Mean body mass index was 25.3 kg/m2. 82.4 and 17.6% of ACL tears were sports (contact—27.5%; non-contact—72.5%) and non-sports injuries (activities of daily living—94.2%, road traffic accidents—5.77%), respectively. The top four sporting activities causing ACL tears were soccer, basketball, racquet games and volleyball. 56.2% of ACL tears presented with concomitant knee injuries (medial meniscus—63.4%; lateral meniscus—31.1%; posterior cruciate ligament—5.49%). 84.5% were primary tears. Conclusions: In this epidemiological review of ACL injuries, we found that ACL injuries tend to cluster within certain population subgroups. Patterns of mechanisms of injuries have been observed. These findings may lead to better preventive and treatment strategies in the management of ACL tears.
Thawing frozen shoulder by steroid injection
Authors: Pushpasekaran Narendran , Kumar Narender , Chopra RK , Borah Diganta , Arora Sumit 
Published: February 2017

Background: Frozen shoulder is not an uncommon disorder, and steroid injection into the glenohumeral (GH) joint is one of the most well-known approaches for the frozen shoulder. However, their results have been varied with beneficial effects or no additional advantage. With the understanding about the pathological changes taking place in frozen shoulder and the biomechanics involved, we wanted to evaluate the short- and long-term efficacy of steroid injection by a novel three-site (NTS) injection technique and compare it with the single-site injection (SSI). Material and methods: This was a prospective study with 85 patients including all stages and randomized into two groups. SSI group received steroid injection through posterior approach. NTS group received the same dose of steroid in diluted doses at three sites (posterior capsule, subacromial and subcoracoid). Second sitting was repeated after 3 weeks. Both groups had received the same physiotherapy. The patients were evaluated by CONSTANT score at initial, 3 week, 6 week and 6 month. Results: NTS group patients had significant pain relief and early improvement in activities of daily living ( p < 0.005). Both groups had improvement in shoulder movements but with NTS group, early near-normal scores were attained and sustained after 6 months. About 43% in SSI group could not attain near-normal levels and had relapses. Conclusion: The three-site approach to steroid instillation in frozen shoulder is a safe method and provides early recovery and better improvement in shoulder function with less relapses.
Three-dimensional dynamic motion analysis of the first carpometacarpal ligaments
Authors: Nanno Mitsuhiko , Kodera Norie , Tomori Yuji , Hagiwara Yusuke , Takai Shinro 
Published: February 2017

Purpose: The purpose of this study was to analyze the dynamic motion of the first carpometacarpal (CMC) ligaments on a three-dimensional (3-D) surface model and to examine the changes in the ligament lengths during the motion of the first CMC joint. Methods: Six fresh-frozen cadaver wrists were used to analyze the motion of the first CMC ligaments on a 3-D coordinate system using a digitizer. Four ligaments, namely, dorsoradial ligament (DRL), posterior oblique ligament (POL), superficial anterior oblique ligament (SAOL), and deep anterior oblique ligament (dAOL), were dissected and identified. Their attachments were digitized and represented on 3-D bone images. The distances between the ligament attachments of the first metacarpal and the trapezium, which were the ligament lengths, were measured during the extension–flexion and adduction–abduction of the first CMC joint. Results: Both the DRL and POL lengthened during flexion of the first CMC joint, and both the SAOL and dAOL lengthened during extension. Both the DRL and SAOL lengthened during adduction, and both the POL and dAOL lengthened during abduction. The DRL alone lengthened significantly at flexion and adduction when the first CMC joint was in dorsoradial dislocation. Conclusions: The lengths of four ligaments changed significantly during first CMC joint motion. This study suggested that the DRL contributes substantial stability to the first CMC joint, preventing dorsoradial dislocation. This 3-D information improves the knowledge and understanding of the function of individual ligaments and their roles in the stability of the first CMC joint.
Orthopaedic surgeon attitudes towards current limitations and the potential for robotic and technological innovation in arthroscopic surgery
Authors: Jaiprakash Anjali , O’Callaghan William B , Whitehouse Sarah L , Pandey Ajay , Wu Liao , Roberts Jonathan , Crawford Ross W 
Published: February 2017

Purpose: To determine the perceptions of surgeons at both consultant and resident level to the difficulties of performing knee arthroscopy and to determine their willingness to adopt robotic technology. Methods: A questionnaire was designed to discern the attitude of orthopaedic consultants and residents to the technical challenges of performing knee arthroscopy and the possible role of robotically enhanced surgery. The questionnaire included 31 questions across five key domains. Results: Iatrogenic damage to articular cartilage was thought to occur in at least 1 in 10 cases by 50% of respondents with 15% believing that it occurred in every case. One hundred or more procedures were thought to be necessary to overcome the learning curve by 40% of respondents and 77.5% believed that 50 procedures or above were necessary. Ninety-nine per cent of respondents agreed that higher technical skills would decrease unintended damage. Despite such difficulties with the procedure and no prior experience with robotic surgery, 47% of respondents see a role for semiautonomous arthroscopic systems in the future. Conclusions: Surgeons believe that knee arthroscopy is a difficult procedure with a long learning curve and a high incidence of iatrogenic cartilage damage. Many find it ergonomically challenging and have frustration with current tools and technology. Clinical Relevance: This is the first study that highlights surgeons’ difficulties performing knee arthroscopy despite the commonly held attitudes that it is a straightforward procedure. Systems that are able to decrease these problems should improve patients’ outcomes and decrease the risk of harm.
Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines
Authors: van Nimwegen Frederika A. , Ntentas Georgios , Darby Sarah C. , Schaapveld Michael , Hauptmann Michael , Lugtenburg Pieternella J. , Janus Cecile P. M. , Daniels Laurien , van Leeuwen Flora E. , Cutter David J. , Aleman Berthe M. P. 
Published: February 2017

Key Points
Risk of HF increases following cardiac radiation doses above 20 Gy. Anthracyclines increase HF rate by threefold independently of radiation.
Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models
Authors: Burkitt Michael D. , Duckworth Carrie A. , Williams Jonathan M. , Pritchard D. Mark 
Published: February 2017

ABSTRACT
Gastric colonization with Helicobacter pylori induces diverse human pathological conditions, including superficial gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma and its precursors. The treatment of these conditions often relies on the eradication of H. pylori, an intervention that is increasingly difficult to achieve and that does not prevent disease progression in some contexts. There is, therefore, a pressing need to develop new experimental models of H. pylori-associated gastric pathology to support novel drug development in this field. Here, we review the current status of in vivo and ex vivo models of gastric H. pylori colonization, and of Helicobacter-induced gastric pathology, focusing on models of gastric pathology induced by H. pylori, Helicobacter felis and Helicobacter suis in rodents and large animals. We also discuss the more recent development of gastric organoid cultures from murine and human gastric tissue, as well as from human pluripotent stem cells, and the outcomes of H. pylori infection in these systems.
Cement-in-cement femoral component revision in the multiply revised total hip arthroplasty
Authors: Sandiford N. A. , Jameson S. S. , Wilson M. J. , Hubble M. J. W. , Timperley A. J. , Howell J. R. 
Published: February 2017

Aims We present the clinical and radiological results at a minimum follow-up of five years for patients who have undergone multiple cement-in-cement revisions of their femoral component at revision total hip arthroplasty (THA). Patients and Methods We reviewed the outcome on a consecutive series of 24 patients (10 men, 14 women) (51 procedures) who underwent more than one cement-in-cement revision of the same femoral component. The mean age of the patients was 67.5 years (36 to 92) at final follow-up. Function was assessed using the original Harris hip score (HHS), Oxford Hip Score (OHS) and the Merle D’Aubigné Postel score (MDP). Results The mean length of follow-up was 81.7 months (64 to 240). A total of 41 isolated acetabular revisions were performed in which stem removal facilitated access to the acetabulum, six revisions were conducted for loosening of both components and two were isolated stem revisions (each of these patients had undergone at least two revisions). There was significant improvement in the OHS (p = 0.041), HHS (p = 0.019) and MDP (p = 0.042) scores at final follow-up There were no stem revisions for aseptic loosening. Survival of the femoral component was 91.9% (95% confidence intervals (CI) 71.5 to 97.9) at five years and 91.7% (95% CI 70 to 97) at ten years (number at risk 13), with stem revision for all causes as the endpoint. Conclusion Cement-in-cement revision is a viable technique for performing multiple revisions of the well cemented femoral component during revision total hip arthroplasty at a minimum of five years follow-up. Cite this article: Bone Joint J 2017;99-B:199–203.
Pre-operative functional mobility as an independent determinant of inpatient functional recovery after total knee arthroplasty during three periods that coincided with changes in clinical pathways
Authors: Sluis G. van der , Goldbohm R. A. , Elings J. E. , Sanden M. W. Nijhuis-van der , Akkermans R. P. , Bimmel R. , Hoogeboom T. J. , Meeteren N. L. van 
Published: February 2017

Aims To investigate whether pre-operative functional mobility is a determinant of delayed inpatient recovery of activities (IRoA) after total knee arthroplasty (TKA) in three periods that coincided with changes in the clinical pathway. Patients and Methods All patients (n = 682, 73% women, mean age 70 years, standard deviation 9) scheduled for TKA between 2009 and 2015 were pre-operatively screened for functional mobility by the Timed-up-and-Go test (TUG) and De Morton mobility index (DEMMI). The cut-off point for delayed IRoA was set on the day that 70% of the patients were recovered, according to the Modified Iowa Levels of Assistance Scale (mILAS) (a 5-item activity scale). In a multivariable logistic regression analysis, we added either the TUG or the DEMMI to a reference model including established determinants. Results Both the TUG (Odds Ratio (OR) 1.10 per second, 95% confidence intervals (CI) 1.06 to 1.15) and the DEMMI (OR 0.96 per point on the 100-point scale, 95% CI 0.95 to 0.98) were statistically significant determinants of delayed IRoA in a model that also included age, BMI, ASA score and ISAR score. These associations did not depend on the time period during which the TKA took place, as assessed by tests for interaction. Conclusion Functional mobility, as assessed pre-operatively by the TUG and DEMMI, is an independent and stable determinant of delayed inpatient recovery of activities after TKA. Future research, focusing on improvement of pre-operative functional mobility through tailored physiotherapy intervention, should indicate whether such intervention enhances post-operative recovery among high-risk patients. Cite this article: Bone Joint J 2017;99-B:211–17.
Weak Capacity and Modulus Comparability in
Ahlfors Regular Metric Spaces
Authors: Lindquist Jeff 
Published: February 2017

Abstract
Let (Z, d, μ) be a compact, connected, Ahlfors Q-regular metric space with Q > 1. Using a hyperbolic
filling of Z,we define the notions of the p-capacity between certain subsets of Z and of theweak covering
p-capacity of path families Γ in Z.We show comparability results and quasisymmetric invariance.As an application
of our methodswe deduce a result due to Tyson on the geometric quasiconformality of quasisymmetric
maps between compact, connected Ahlfors Q-regular metric spaces.