bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and risk factors of latent tuberculosis infection in Africa: a systematic review and meta-analysis protocol
Authors: Basera Tariro J , Ncayiyana Jabulani , Engel Mark E 
Published: July 2017

IntroductionLatent tuberculosis infection (LTBI) remains a major public health problem and one of the major contributors to the pool of active tuberculosis cases. The true burden of LTBI in Africa is not known. Early modelling studies estimate that over 33% of the world’s population is infected with latent tuberculosis. We propose conducting a systematic review and a meta-analysis to evaluate the burden and risk factors of LTBI in Africa reported in studies from 2000 to 2017.Methods and analysisWe will include cross-sectional studies, cohort studies and case-control studies estimating either tuberculin skin test (TST) or interferon-gamma release assay (IGRA) confirmed prevalence of LTBI and associated risk factors among people in African countries. A comprehensive search of relevant literature will be conducted on electronic databases using common and medical subject heading (MeSH) terms for LTBI, and an African search filter. Risk of bias will be evaluated by assessing all qualifying full-text articles for quality and eligibility using a quality score assessment tool. Standardised data extraction will be carried out after which prevalence estimates will be pooled using random-effects models in Stata V.13. Where there is sufficient data , subgroup meta-analyses will be conducted by risk factors including participant’s age group, occupation, location and HIV status. This systematic review will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses Protocols 2015 Statement.Ethics and disseminationNo ethical issues were foreseen given that this was a protocol for a systematic review of published studies. The results of this study will be published in a peer-reviewed journal and presented at conferences.Trial registration numberSystematic review registration: PROSPERO CRD42016037997
Retrospective analysis of newly recorded certifications of visual impairment due to diabetic retinopathy in Wales during 2007–2015
Authors: Thomas Rebecca L , Luzio Stephen D , North Rachel V , Banerjee Sanjiv , Zekite Antra , Bunce Catey , Owens David R 
Published: July 2017

ObjectiveThe aim of this study was to analyse the changes in new certifications for both sight impairment (SI) and severe sight impairment (SSI, blindness) in Wales due to diabetic retinopathy (DR)/maculopathy between 2007 and 2015.Research design and methodsThis is a retrospective analysis of annual data of new certifications for visual impairment and blindness (Certificate of Vision Impairment) for England and Wales derived from the national database provided by the Certifications Office, Moorfields Eye Hospital, over a period of 8 years from 2007.ResultsIn Wales there were 339 less new certifications for both SI and severe SSI from any cause combined from 2007–2008 to 2014–2015. The number SI and SSI combined specifically due to DR was reduced by 22 in people with known diabetes. This was a reduction in new certifications over the observation period from 82.4 to 46.9 per 100 000 (−43.1%) with a fall in SSI from 31.3 to 15.8 per 100 000 (−49.4%), respectively. During this observation period however, there was a parallel increase in 52 229 (39.8%) persons with diabetes in Wales.ConclusionsWhile acknowledging the limitations of the certification process and the increasing numbers of persons with diabetes, the incidence of SI and SSI per 100 000 population of persons with diabetes in Wales has almost halved over an 8-year period up to 2015. This may reflect the earlier diagnosis of DR and sight-threatening DR since the introduction of screening and/or improved diabetes management with timely onward referral and newer treatments.
Concomitant preterm birth and severe small-for-gestational age birth weight among infants of immigrant mothers in Ontario originating from the Philippines and East Asia: a population-based study
Authors: Bartsch Emily , Park Alison L , Jairam Jennifer , Ray Joel G 
Published: July 2017

ObjectivesWomen from the Philippines form one of the largest immigrant groups to North America. Their newborns experience higher rates of preterm birth (PTB), and separately, small-for-gestational age (SGA) birth weight, compared with other East Asians. It is not known if Filipino women are at elevated risk of concomitant PTB and severe SGA (PTB–SGA), a pathological state likely reflective of placental dysfunction and neonatal morbidity.MethodsWe conducted a population-based study of all singleton or twin live births in Ontario, from 2002 to 2011, among immigrant mothers from the Philippines (n=27 946), Vietnam (n=15 297), Hong Kong (n=5618), South Korea (n=5148) and China (n=42 517). We used modified Poisson regression to generate relative risks (RR) of PTB-SGA, defined as a birth <37 weeks’ gestation and a birth weight <5th percentile. RRs were adjusted for maternal age, parity, marital status, income quintile, infant sex and twin births.ResultsRelative to mothers from China (2.3 per 1000), the rate of PTB–SGA was significantly higher among infants of mothers from the Philippines (6.5 per 1000; RR 2.91, 95% CI 2.27 to 3.73), and those from Vietnam (3.7 per 1000; RR 1.68, 95% CI 1.21 to 2.34). The RR of PTB–SGA was not higher for infants of mothers from Hong Kong or South Korea.InterpretationAmong infants born to immigrant women from five East Asian birthplaces, the risk of PTB–SGA was highest among those from the Philippines. These women and their fetuses may require additional monitoring and interventions.
MDHAQ/RAPID3 scores in patients with osteoarthritis are similar to or higher than in patients with rheumatoid arthritis: a cross-sectional study from current routine rheumatology care at four sites
Authors: El-Haddad Carlos , Castrejon Isabel , Gibson Kathryn A , Yazici Yusuf , Bergman Martin J , Pincus Theodore 
Published: July 2017

ObjectiveTo compare patients with a primary diagnosis of osteoarthritis (OA) versus rheumatoid arthritis (RA) for scores on a patient self-report MDHAQ/RAPID3 (Multidimensional Health Assessment Questionnaire/Routine Assessment of Patient Index Data 3), and for physician global assessment (DOCGL).MethodsAll patients with all diagnoses complete an MDHAQ/RAPID3 at all routine rheumatology visits in the waiting area before seeing a rheumatologist at four sites, one in Australia and three in the USA. The two-page MDHAQ includes 0–10 scores for physical function (in 10 activities), pain and patient global assessment [on 0–10 visual analogue scales (VAS)], compiled into a 0–30 RAPID3, as well as fatigue and self-report painful joint count scales. Rheumatologists estimate a 0–10 DOCGL VAS. Demographic, MDHAQ/RAPID3 and DOCGL data from a random visit were compared in patients with RA versus patients with OA using multivariate analysis of variance, adjusted for age, disease duration and formal education level.ResultsMedian RAPID3 was higher in OA versus RA at all four sites (11.7–16.8 vs 6.2–11.8) (p<0.001 at three sites). Median DOCGL in OA versus RA was 5 vs 4, 4 vs 3.7, 2.2 vs 2.5 and 2 vs 1. Patterns were similar for individual RAPID3 items, fatigue and painful joint scales, and in stratified analyses of patients aged 55–70.ConclusionPatient MDHAQ/RAPID3 and physician DOCGL indicate similar or higher disease burden in OA versus RA. Routine MDHAQ/RAPID3 allows direct comparisons of the two diseases. The findings suggest possible revision of current clinical and public policy views concerning OA.
Prediction and benefits of minimal disease activity in patients with psoriatic arthritis and active skin disease in the ADEPT trial
Authors: Mease Philip J , Kavanaugh Arthur , Coates Laura C , McInnes Iain B , Hojnik Maja , Zhang Ying , Anderson Jaclyn K , Dorr Alexander P , Gladman Dafna D 
Published: July 2017

ObjectivesTo determine the proportion of patients with psoriatic arthritis in the Adalimumab Effectiveness in Psoriatic Arthritis trial achieving minimal disease activity (MDA) and its individual components at 1 or more visits over 144 weeks, identify baseline predictors of MDA achievement, and evaluate the association of MDA status with independent quality of life (QoL)-related patient-reported outcomes (PROs).MethodsUnivariate and multivariate analyses were used to identify the baseline characteristics that predicted achievement of MDA at individual time points (weeks 12 through 144) or sustained MDA (achievement of MDA at 2 consecutive time points 12 weeks apart). The association of independent QoL-related PROs with MDA achievement was evaluated at weeks 24 and 144.ResultsIn univariate analyses, higher baseline patient assessment of pain, tender joint count (TJC), enthesitis and Health Assessment Questionnaire-Disability Index (HAQ-DI) score were significantly associated with lower likelihood of achieving MDA at later time points. Multivariate analyses confirmed higher baseline HAQ-DI as a significant predictor for failure to achieve MDA at later time points. Achievement of sustained MDA was associated with lower baseline TJC and HAQ-DI score. Achievement of different MDA components appeared to be treatment dependent. MDA achievers had significantly better QoL-related PROs and greater improvements in PROs from baseline to week 24 compared with non-achievers.ConclusionsHigher HAQ-DI score was the most consistent baseline factor that decreased the likelihood of achieving MDA and sustained MDA at later time points. Achieving MDA was associated with better independent QoL-related PROs.
Representing delayed force feedback as a combination of current and delayed states
Authors: Avraham Guy , Mawase Firas , Karniel Amir , Shmuelof Lior , Donchin Opher , Mussa-Ivaldi Ferdinando A. , Nisky Ilana 
Published: July 2017

To adapt to deterministic force perturbations that depend on the current state of the hand, internal representations are formed to capture the relationships between forces experienced and motion. However, information from multiple modalities travels at different rates, resulting in intermodal delays that require compensation for these internal representations to develop. To understand how these delays are represented by the brain, we presented participants with delayed velocity-dependent force fields, i.e., forces that depend on hand velocity either 70 or 100 ms beforehand. We probed the internal representation of these delayed forces by examining the forces the participants applied to cope with the perturbations. The findings showed that for both delayed forces, the best model of internal representation consisted of a delayed velocity and current position and velocity. We show that participants relied initially on the current state, but with adaptation, the contribution of the delayed representation to adaptation increased. After adaptation, when the participants were asked to make movements with a higher velocity for which they had not previously experienced with the delayed force field, they applied forces that were consistent with current position and velocity as well as delayed velocity representations. This suggests that the sensorimotor system represents delayed force feedback using current and delayed state information and that it uses this representation when generalizing to faster movements. NEW & NOTEWORTHY The brain compensates for forces in the body and the environment to control movements, but it is unclear how it does so given the inherent delays in information transmission and processing. We examined how participants cope with delayed forces that depend on their arm velocity 70 or 100 ms beforehand. After adaptation, participants applied opposing forces that revealed a partially correct representation of the perturbation using the current and the delayed information.
Emergent cortical circuit dynamics contain dense, interwoven ensembles of spike sequences
Authors: Dechery Joseph B. , MacLean Jason N. 
Published: July 2017

Temporal codes are theoretically powerful encoding schemes, but their precise form in the neocortex remains unknown in part because of the large number of possible codes and the difficulty in disambiguating informative spikes from statistical noise. A biologically plausible and computationally powerful temporal coding scheme is the Hebbian assembly phase sequence (APS), which predicts reliable propagation of spikes between functionally related assemblies of neurons. Here, we sought to measure the inherent capacity of neocortical networks to produce reliable sequences of spikes, as would be predicted by an APS code. To record microcircuit activity, the scale at which computation is implemented, we used two-photon calcium imaging to densely sample spontaneous activity in murine neocortical networks ex vivo. We show that the population spike histogram is sufficient to produce a spatiotemporal progression of activity across the population. To more comprehensively evaluate the capacity for sequential spiking that cannot be explained by the overall population spiking, we identify statistically significant spike sequences. We found a large repertoire of sequence spikes that collectively comprise the majority of spiking in the circuit. Sequences manifest probabilistically and share neuron membership, resulting in unique ensembles of interwoven sequences characterizing individual spatiotemporal progressions of activity. Distillation of population dynamics into its constituent sequences provides a way to capture trial-to-trial variability and may prove to be a powerful decoding substrate in vivo. Informed by these data, we suggest that the Hebbian APS be reformulated as interwoven sequences with flexible assembly membership due to shared overlapping neurons. NEW & NOTEWORTHY Neocortical computation occurs largely within microcircuits comprised of individual neurons and their connections within small volumes (<500 μm3). We found evidence for a long-postulated temporal code, the Hebbian assembly phase sequence, by identifying repeated and co-occurring sequences of spikes. Variance in population activity across trials was explained in part by the ensemble of active sequences. The presence of interwoven sequences suggests that neuronal assembly structure can be variable and is determined by previous activity.
Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells
Authors: Sampson Josephina , O'Regan Laura , Dyer Martin J.S. , Bayliss Richard , Fry Andrew M. 
Published: July 2017

Abstract
Cancer cells frequently possess extra amplified centrosomes clustered into two poles whose pseudo-bipolar spindles exhibit reduced fidelity of chromosome segregation and promote genetic instability. Inhibition of centrosome clustering triggers multipolar spindle formation and mitotic catastrophe, offering an attractive therapeutic approach to selectively kill cells with amplified centrosomes. However, mechanisms of centrosome clustering remain poorly understood. Here, we identify a new pathway that acts through NIMA-related kinase 6 (Nek6) and Hsp72 to promote centrosome clustering. Nek6, as well as its upstream activators polo-like kinase 1 and Aurora-A, targeted Hsp72 to the poles of cells with amplified centrosomes. Unlike some centrosome declustering agents, blocking Hsp72 or Nek6 function did not induce formation of acentrosomal poles, meaning that multipolar spindles were observable only in cells with amplified centrosomes. Inhibition of Hsp72 in acute lymphoblastic leukemia cells resulted in increased multipolar spindle frequency that correlated with centrosome amplification, while loss of Hsp72 or Nek6 function in noncancer-derived cells disturbs neither spindle formation nor mitotic progression. Hence, the Nek6–Hsp72 module represents a novel actionable pathway for selective targeting of cancer cells with amplified centrosomes. Cancer Res; 77(18); 4785–96. ©2017 AACR.
MAPK Pathway and TERT Promoter Gene Mutation Pattern and Its Prognostic Value in Melanoma Patients: A Retrospective Study of 2,793 Cases
Authors: Bai Xue , Kong Yan , Chi Zhihong , Sheng Xinan , Cui Chuanliang , Wang Xuan , Mao Lili , Tang Bixia , Li Siming , Lian Bin , Yan Xieqiao , Zhou Li , Dai Jie , Guo Jun , Si Lu 
Published: July 2017

Abstract
Purpose: Ethnic differences are conspicuous in melanoma. This study is to obtain a comprehensive view of a genomic landscape and a better understanding of the correlations of gene mutation status with clinicopathologic characteristics and disease prognosis in the Asian population.
Experimental Design: A total of 2,793 melanoma patient samples were retrospectively collected and analyzed for mutations in C-KIT, BRAF, NRAS, and PDGFRA coding regions and telomerase reverse transcriptase (TERT) promoter region by Sanger sequencing. Mutations were correlated to clinicopathologic features and overall survival.
Results: The incidences of somatic mutations within the BRAF, NRAS, C-KIT, TERT-228, TERT-250, and PDGFRA genes were 23.7%, 10.4%, 8.0%, 5.9%, 5.5%, and 1.4%, respectively. Hotspot mutations accounted for 95.8% and 87.2% of BRAF and NRAS mutations, respectively; meanwhile, C-KIT and PDGFRA mutations showed more heterogeneity. BRAF, C-KIT, and NRAS mutations were mutually exclusive. BRAF, C-KIT, NRAS, and numbers of gene mutations of the MAPK pathway were all independent negative prognostic factors (P = 0.007, other P &lt; 0.001, respectively). In acral melanoma, BRAF, C-KIT, and NRAS mutations were all independent prognostic factors of worse overall survival (all P &lt; 0.001), whereas in mucosal melanoma, only C-KIT was (P = 0.006). Although correlated with BRAF mutations (P = 0.001 and P &lt; 0.001 for C228T and C250T, respectively), TERT promoter gene mutations were not correlated with overall survival (P = 0.406 and 0.256, respectively).
Conclusions: The MAPK pathway and TERT promoter gene mutations are differentially represented in the Asian population. Mutations in BRAF, C-KIT, and NRAS have prognostic values that vary by melanoma subtypes. Clinical treatment targeting these critical pathways should be aimed directly at these poor-prognosis subpopulations for maximum potential impact. Clin Cancer Res; 23(20); 6120–7. ©2017 AACR.
Low-Level Jets over Utö, Finland, Based on Doppler Lidar Observations
Authors: Tuononen Minttu , O’Connor Ewan J. , Sinclair Victoria A. , Vakkari Ville 
Published: July 2017

AbstractOver two years of meteorological observations from Utö, a small island in the Finnish outer archipelago in the Baltic Sea, were used to investigate the occurrence and characteristics of low-level jets (LLJs) and the diurnal and seasonal variations in these properties. An objective LLJ identification algorithm that is suitable for high-temporal-and-vertical-resolution Doppler lidar data was created and applied to wind profiles obtained from a combination of Doppler lidar data and two-dimensional sonic anemometer observations. This algorithm was designed to identify coherent LLJ structures and requires that they persist for at least 1 h. The long-term mean LLJ frequency of occurrence at Utö was 12%, the mean LLJ wind speed was 11.6 m s−1, and the vast majority of identified LLJs occurred below 150 m above ground level. The LLJ frequency of occurrence was much higher during summer (21%) and spring (18%) than in autumn (8%) and winter (3%). During winter and spring, the LLJ frequency of occurrence is evenly distributed throughout the day. In contrast, the LLJ frequency of occurrence peaks at night (1900–0100 UTC) during summer and during the evening hours (1700–1900 UTC) in autumn. The highest and strongest LLJs come from the southwest, which is also the predominant LLJ direction in all seasons. LLJs below 100 m are common in spring and summer, are weaker, and do not show a strong directional dependence.
Momentum Flux of Convective Gravity Waves Derived from an Offline Gravity Wave Parameterization. Part I: Spatiotemporal Variations at Source Level
Authors: Kang Min-Jee , Chun Hye-Yeong , Kim Young-Ha 
Published: July 2017

Abstract
Spatiotemporal variations in momentum flux spectra of convective gravity waves (CGWs) at the source level (cloud top), including nonlinear forcing effects, are examined based on calculations using an offline version of CGW parameterization and global reanalysis data for a period of 32 years (1979–2010). The cloud-top momentum flux (CTMF) is not solely proportional to the convective heating rate but is affected by the wave-filtering and resonance factor and background stability and temperature underlying the convection. Consequently, the primary peak of CTMF is in the winter hemisphere midlatitudes, associated with storm tracks, where a secondary peak of convective heating exists, whereas the secondary peak of CTMF appears in the summer hemisphere tropics and intertropical convergence zone (ITCZ), where the primary peak of convective heating exists. The magnitude of CTMF fluctuates largely with 1-yr and 1-day periods in major CTMF regions. At low latitudes and Pacific storm-track regions, a 6-month period is also significant, and the decadal cycle appears in the southern Andes. The equatorial eastern Pacific region exhibits a substantial interannual to decadal scale of variabilities. The correlation between convective heating and the CTMF is relatively lower in the equatorial region than in other regions. The CTMF in 10°N–10°S during the period of the pre-Concordiasi campaign approximately follows a lognormal distribution but with a slight underestimation in the tail of the probability density function. In Part II, the momentum flux and drag of CGW in the stratosphere will be examined.
Shallow Precipitation Detection and Classification Using Multifrequency Radar Observations and Model Simulations
Authors: Arulraj Malarvizhi , Barros Ana P. 
Published: July 2017

AbstractDetection of shallow warm rainfall remains a critical source of uncertainty in remote sensing of precipitation, especially in regions of complex topographic and radiometric transitions, such as mountains and coastlines. To address this problem, a new algorithm to detect and classify shallow rainfall based on space–time dual-frequency correlation (DFC) of concurrent W- and Ka-band radar reflectivity profiles is demonstrated using ground-based observations from the Integrated Precipitation and Hydrology Experiment (IPHEx) in the Appalachian Mountains (MV), United States, and the Biogenic Aerosols–Effects on Clouds and Climate (BAECC) in Hyytiala (TMP), Finland. Detection is successful with false alarm errors of 2.64% and 4.45% for MV and TMP, respectively, corresponding to one order of magnitude improvement over the skill of operational satellite-based radar algorithms in similar conditions. Shallow rainfall is misclassified 12.5% of the time at MV, but all instances of low-level reverse orographic enhancement are detected and classified correctly. The classification errors are 8% and 17% for deep and shallow rainfall, respectively, in TMP; the latter is linked to reflectivity profiles with dark band but insufficient radar sensitivity to light rainfall ( mm h−1) remains the major source of error. The potential utility of the algorithm for satellite-based observations in mountainous regions is explored using an observing system simulation (OSS) of concurrent CloudSat Cloud Profiling Radar (CPR) and GPM Dual-Frequency Precipitation Radar (DPR) during IPHEx, and concurrent satellite observations over Borneo. The results suggest that integration of the methodology in existing regime-based classification algorithms is straightforward, and can lead to significant improvements in the detection and identification of shallow precipitation.