bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered sleep patterns in patients with non-functional GHRH receptor
Authors: Oliveira Francielle T , Salvatori Roberto , Marcondes José , Macena Larissa B , Oliveira-Santos Alecia A , Faro Augusto C N , Campos Viviane C , Oliveira Carla R P , Costa Ursula M M , Aguiar-Oliveira Manuel H 
Published: April 2017

ObjectivesGH-releasing hormone (GHRH) exerts hypnotic actions increasing the non-rapid eye movement (NREM) sleep. Conversely, GH stimulates the REM sleep. GH deficiency (GHD) often leads to sleep problems, daytime fatigue and reduced quality of life (QoL). GHD may be due to lack of hypothalamic GHRH or destruction of somatotroph cells. We have described a cohort with isolated GHD (IGHD) due to GHRH resistance caused by a homozygousnullmutation (c.57 + 1G > A) in the GHRH receptor gene. They have normal QoL and no obvious complaints of chronic tiredness. The aim of this study was to determine the sleep quality in these subjects.MethodsA cross-sectional study was carried out in 21 adult IGHD subjects, and 21 age- and gender-matched controls. Objective sleep assessment included polygraphic records of the awake, stages NREM [N1 (drowsiness), N2 and N3 (already sleeping)] and REM (R). Subjective evaluation included the Pittsburgh Sleep Quality Index, the Insomnia Severity Index and the Epworth Sleepiness Scale.ResultsIGHD subjects showed a reduction in sleep efficiency (P = 0.007), total sleep time (P = 0.028), duration of N2 and R in minutes (P = 0.026 andP = 0.046 respectively), but had increased duration and percentage of N1 stage (P = 0.029 andP = 0.022 respectively), wake (P = 0.007) and wake-time after sleep onset (P = 0.017). There was no difference in N3 or in sleep quality questionnaire scores.ConclusionPatients with IGHD due to GHRH resistance exhibit objective reduction in the sleep quality, with changes in NREM and REM sleep, with no detectable subjective consequences. GHRH resistance seems to have a preponderant role over GHD in the sleep quality of these subjects.
Everolimus Plus Exemestane in Advanced Breast Cancer: Safety Results of the BALLET Study on Patients Previously Treated Without and with Chemotherapy in the Metastatic Setting
Authors: Generali Daniele , Montemurro Filippo , Bordonaro Roberto , Mafodda Antonino , Romito Sante , Michelotti Andrea , Piovano Pierluigi , Ionta Maria Teresa , Bighin Claudia , Sartori Donata , Frassoldati Antonio , Cazzaniga Marina Elena , Riccardi Ferdinando , Testore Franco , Vici Patrizia , Barone Carlo Antonio , Schirone Alessio , Piacentini Federico , Nolè Franco , Molino Annamaria , Latini Luciano , Simoncini Edda Lucia , Roila Fausto , Cognetti Francesco , Nuzzo Francesco , Foglietta Jennifer , Minisini Alessandro Marco , Goffredo Francesca , Portera Giuseppe , Ascione Gilda , Mariani Gabriella 
Published: April 2017

Abstract

Background
The BALLET study was an open-label, multicenter, expanded access study designed to allow treatment with everolimus plus exemestane in postmenopausal women with hormone receptor-positive metastatic breast cancer progressed following prior endocrine therapy. A post hoc analysis to evaluate if previous chemotherapy in the metastatic setting affects the safety profile of the combination regimen of everolimus and exemestane was conducted on the Italian subset, as it represented the major part of the patients enrolled (54%).

Patients and Methods
One thousand one hundred and fifty-one Italian patients were included in the present post hoc analysis, which focused on two sets of patients: patients who never received chemotherapy in the metastatic setting (36.1%) and patients who received at least one chemotherapy treatment in the metastatic setting (63.9%).

Results
One thousand one hundred and sixteen patients (97.0%) prematurely discontinued the study drug, and the main reasons reported were disease progression (39.1%), local reimbursement of everolimus (31.1%), and adverse events (AEs) (16.1%). The median duration of study treatment exposure was 139.5 days for exemestane and 135.0 days for everolimus. At least one AE was experienced by 92.5% of patients. The incidence of everolimus-related AEs was higher (83.9%) when compared with those that occurred with exemestane (29.1%), and the most commonly reported everolimus-related AE was stomatitis (51.3%). However, no significant difference in terms of safety related to the combination occurred between patients without and with chemotherapy in the metastatic setting.

Conclusion
Real-life data of the Italian patients BALLET-related cohort were an adequate setting to state that previous chemotherapy did not affect the safety profile of the combination regimen of everolimus and exemestane.
RELACIÓN DEL PROVEEDOR DE SERVICIOS FARMACÉUTICOS CON SUS CLIENTES: UNA MIRADA DESDE EL MARKETING RELACIONAL EN EL DEPARTAMENTO DE SUCRE
Authors: Martínez Benítez John Pablo 
Published: April 2017

El presente artículo de investigación se realizó con el objetivo de analizar la relación del proveedor de servicios farmacéuticos con sus clientes, desde el marketing relacional en el departamento de Sucre (Colombia). El estudio se fundamentó en la perspectiva del paradigma interpretativo, y se utilizó el método de investigación descriptivo, basado en la estructura de investigación de Quivy y Campenhoudt, que se articuló con las etapas del procedimiento científico. Entre los resultados obtenidos, se destaca la identificación de tres tipos de clientes en el sector farmacéutico. Además, se encontró que los proveedores de este sector en Sucre han generado fuertes lazos con sus clientes, a pesar de que los canales de comunicación con estos son insuficientes. Los proveedores farmacéuticos también han generado alianzas con los distribuidores mayoristas para satisfacer las necesidades de los clientes. Se concluyó que para qué la relación del sector farmacéutico con sus clientes perdure, se requiere brindar un servicio que inspire confianza y le proporcione al cliente la seguridad de que el producto que se le ofrece llena sus expectativas. ABSTRACTThis research paper, whose aim was to analyze the relationship between pharmaceutical services provider and customers from the relationship marketing in Sucre, Colombia. The study was based on the perspective of the interpretive paradigm and the research method used was descriptive, based on the research structure of Quivy and Campenhouldt, articulated with the stages in the scientific procedure. Among the results obtained, three types of clients within the pharmaceutical sector were identified; besides, providers of the Pharmaceutical sector in Sucre have created strong bonds with their customers, despite the fact that channels of communication with them are insufficient. Pharmaceutical providers have also created partnerships with wholesale distributors of the Pharmaceutical sector to meet the customers’ needs. It was concluded that for the relationship between the Pharmaceutical sector and clients’ lasts, it requires to provide a service that inspires confidence and assure them that the product offered will meet their expectations.
Epidemiology of major limb amputations: a cross sectional study from a South Indian tertiary care hospital
Authors: P. Unnikrishnan E. , Rollands Rakesh , Parambil Sasi M. 
Published: April 2017

Background: Limb loss to amputation is a major problem especially in developing countries where majority of the cases are preventable. It is a burden, not just for the patient, but also for their care givers which imposes tremendous financial and psychological burden upon them. The aim was to outline the patterns, indications and short term complications of major limb among patients attending Government Medical College, Kozhikode, Kerala, India which is a tertiary care centre.Methods: This was a prospective, observational study that was conducted at Govt. Medical College, Kozhikode, for a period of 18 months. 81 patients underwent major limb amputations in our hospital during the study period.Results: The age ranged between 23 to 90 years (mean 59.23±14.79). Males outnumber females by a ratio of 4:1. Above knee (transtibial) amputations were the most common. Diabetes mellitus was the most common cause (39.5%) followed by chronic NDMVI (33.3%). Younger individuals who underwent amputation were mostly due to trauma. Most common post op complication was surgical site infection (21%) and the most common organism cultured from the wound was Pseudomonas (50%). The most common additional procedure done was wound debridement. Themortality rate was 10% and mean duration of hospital stay was 23 days. Conclusions: Complications of diabetic foot ulcers and chronic vascular disease were the most common indications for major limb amputation in our environment. Trauma was the most common indication in younger individuals. The majority of these amputations are preventable by provision of health education, early presentation and appropriate management of the common indications.
PUSAT PEMELIHARAAN KESEHATAN, KECANTIKAN, DAN KEBUGARAN KHUSUS WANITA DENGAN KONSEP HEALING ENVIRONMENT DI SURAKARTA
Authors: Azizati Aini , Wahyuwibowo Agung Kumoro , Yuliarso Hari 
Published: April 2017

<p><em>Modern women in urban areas with high mobility, tend to be easily stress and then impact on her body fitness, beauty, and even her health. Stress has become part of modern human life, and one way to cure it is with relaxation. Nowadays not only the beauty treatments but also health care are also sought by women. There is connection between beauty and health, because they’re influence and rely on each other. Beauty basically will decrease and fade, if their body not health, and vice versa. Modern women who has little time, requires an efficient and practical way of treatment to relaxation her body. This issue bring the idea to design a special space to fulfill of women needs, where is consist of health, beauty, and fitness care center. The formulation of the problems in this design is to realize six principles of healing environment. This care center is designed as a place that provides a variety of women needs from health, beauty, fitness, and also as a relaxation space. So it requires a comfortable and quiet atmosphere. Healing environment was selected as the method of design concepts, so can be expected to provide quiet atmosphere, and also can accommodate visitors to help the healing process both physically and psychologically, so</em><em> </em><em>that visitors can get fitter. </em><em>The application of healing environment concept applied trough nature texture and material so can give perseption to visitors to feel close with nature</em><em>, </em><em> and health colour applied in interior trough furniture or wall colour. The application of healing environment concept in exterior applied trough healing garden with variety and colours of vegetation in exterior.</em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: Care Center, Healing garden, Healing environment, Surakarta.</em></p>
PERANCANGAN DAN PENGEMBANGAN TERMINAL PENUMPANG BANDARA INTERNASIONAL RADIN INTEN II LAMPUNG
Authors: Saprilantu Galih , Iswati Tri Yuni , Sumadyo Amin 
Published: April 2017

<p><em>Lampung Province area development that keeps increasing every year, in tune with new anyway that is the industrial sector and increasing tourism anyway. Liquid air transport one of the factors that play a role in developing regional Lampung, in addition it also in modern air transport become main options as a means of access to this provincial entry exit. Lampung Province local Government planned to maximize the group by doing airport development Radin Inten II airport into an international class that can accomodate superbly will access inward or outward in the sphere of Indonesia (SNI) and internationally. Development and design of the airport focused more to the passenger terminal, without neglecting other support facilities. Design question is how petite and mass terminal developed concept able to accommodate the predicted flight activities will grow each year, as well as the Lampung Province local wisdom impressions that will be highlighted. This method is used in the design and development is the method of architecture, so that the results obtained are supporting facilities that comply with the standard of the airport that simply playing on international flights, as well as the development of the area of the terminal in order to maximize undertakes activities in it.</em><em></em></p><p><em> </em></p><strong><em>Keywords</em></strong><em>: Development, Passanger Terminal, International Airport, Radin Inten II, Lampung Province.</em>
PLACEMAKING RUANG JALAN KORIDOR KOMERSIAL KOTA SURAKARTA
Authors: T Patrani Victorya , Utomo Rizon Pamardhi , Yudana Galing 
Published: April 2017

<p><em>Placemaking is an attempt to form a space into a place that has meaning for its users. The concept of placemaking motivated by all the existing space in the city, both of street and public space that can have meaning as a place where it will occur at the site of social interaction and communication among users of space. Street in a commercial corridor in Surakarta is an important infrastructure to support commercial activities, but the function of the cause of street becomes passive and less interested in the community to conduct joint activities in that space. This shows that street is still not able to accommodate other activities simultaneously and social interactions that lead to placemaking. The problem in this study is whether placemaking already happening commercial corridor street and how much street placemaking commercial corridors. Scope of this research include the way to commercial corridor </em><em>S</em><em>urakarta with sample corridor commercial there are six . The method used to determine how much placemaking happened in the commercial corridor of </em><em>street</em><em> to be reviewed based on variables derived from placemaking elements, namely comfort and i</em><em>mage</em><em>, accessibility and li</em><em>nkage</em><em>, </em><em>uses</em><em> and activities, as well as sosialibilit</em><em>y</em><em>. The research proves that placemaking has occurred in the commercial corridor of street in Surakarta. But the realization of placemaking in commercial corridor street is still weak, as indicated by the lack of availability of means of supporting activities in the form sitting group. Pedestrian walkway used for informal traders activity and social interaction has not been evenly occurs in the entirety of the commercial corridors in the city of Surakart</em><em>a.</em></p><p><strong><em> </em></strong></p><p><strong><em>Keywords:</em></strong><em> </em><em>placemaking, street, commercial corridor.</em><em></em></p>
PENGEMBANGAN WISATA BUKIT TARUWONGSO MENJADI TAMAN SATWA TARUWONGSO DENGAN PRINSIP ARSITEKTUR HIJAU DI SUKOHARJO
Authors: Winoto Ardi , Wahyuwibowo Agung Kumoro , Pramesti Leny 
Published: April 2017

<p><em>Taruwongso is a tourist destination in Sukoharjo with major potential is wildlife and nature. However, in the absence of a manager, a lack of attention by people around, and visitors irresponsible, so many animals at Taruwongso hill who have lost their natural habitat.</em></p><p><em>As the rescue efforts of wildlife and nature Taruwongso hill, the need for the development of Taruwongso hill travel into Taruwongso Animal Park that can accommodate a synergy between human behavior, animal behavior, and the behavior of nature in Sukoharjo.</em></p><p><em>The problem of the design are: a synergy between human behavior, animal behavior, and the behavior of nature that will be contained greatly affect the shape Taruwongso Animal Park.</em></p><p><em>Principles of Green Architecture is used as a basis for the synergy between human behavior, animal behavior, and the behavior of nature in Taruwongso Animal Park.</em></p><p><em>The results obtained Animal Park is a design that can accommodate a synergy between human behavior, animal behavior, and the behavior of nature with the principles of Green Architecture.</em></p><p><em> </em></p><strong><em>Keywords</em></strong><em>: Animal Park, Architecture, Green Architecture, Taruwongso Hill.</em>
Implementasi Outdoor Learning untuk Meningkatkan Hasil Belajar Kognitif Mahasiswa pada Mata Kuliah Sistematika Tumbuhan Tinggi
Authors: Nugroho Anwari Adi , Hanik Nur Rokhimah 
Published: April 2017

Outdoor learning was learning that gives students the opportunity to explore the surrounding environment as a source of learning. Students are required to be able to construct knowledge independently throgh the process of exploring the learning environment in Systematics of High Plant. This research aims to improve student cognitive learning outcomes through the implementation of outdoor learning in the subject of High Plant Systematics. The method used was classroom action research with 3 cycles. Each cycle consists of four basic stages, namely planning, implementation, observation and reflection. Samples used in this study was 22 fourth semester students of Biology Education Study Program, Faculty of Teaching and Education, University of Veteran Bangun Nusantara Sukoharjo .The study was conducted in March and May 2015. The cognitive learning was measured through the posttest. The results showed that the cognitive learning outcomes of students increased from the first cycle to the second cycle amounted to 27.56% and from the second cycle to the third cycle of 10.20%. Target of cognitive learning outcomes at least achieved grade of 75 in average.
Project Based Learning to Improve Written Argumentation Skill of Tenth Graders
Authors: TAMA NOVIAN BUDI , PROBOSARI RIEZKY MAYA , WIDORETNO SRI , INDRIYATI INDRIYATI 
Published: April 2017

The objectives of this research was to improve students written argumentation of the tenth grader of science class in a senior high school in Central Java through the aplication of projcet based learning. This research was a classroom action research conducted in three cycles. Each cycle consists of 4 stages, namely: planning, action, observing and reflecting. The subject of this research was 30 students in science class. The data of this research were obtained from test, observation and documentation. This research was descriptive qualitative research which was analyzed through three components: data reduction, data presentation, and taking the conclusion or verification. This research used a spiral model. The result shows that the aplication of project based learning improved students written argumentation skill, i.e. 22,04% in the pre-cycle, 30,48 in the first cycle, 25,74% in the second cycle, and 32,01% in the third cycle. It can be said that the implemantation of project based learning can improve students' written argumentation skill in science class.
THE TRANSLATION OF ELLIPSIS AND EVENT REFERENCE IN JK ROWLING'S HARRY POTTER AND THE GOBLET OF FIRE
Authors: Sujono Adi Loka 
Published: April 2017

<p>The study aims to investigate the translation of ellipsis and event reference in JK Rowling‘s‘ Harry Potter and the Goblet of Fire. In this present study, a qualitative content analysis method was employed. In translating the ellipsis and event reference, semantic and syntactic referents should be taken into account. Concerning with reference to eventualities, three forms of referents namely verb phrase ellipsis, so anaphora and pronominal event reference are analysed. Some adjustments such as literal translation, explicitation, omission, and the like are made.</p>
KAJIAN ANALISIS WACANA KRITIS PADA CERITA BERGAMBAR ANAK DWI BAHASA KURA-KURA SI PENJAGA SAMUDRA (TURTLE THE GUARD OF THE OCEAN)
Authors: Wibowo Agung Prasetyo 
Published: April 2017

<p>Tulisan ini menyajikan kajian wacana kritis terhadap cerita bergambar bilingual<br />Kura-Kura Si Penjaga Samudra. Investigasi kritis itu difokuskan pada kekuatan<br />bahasa pada tataran mikro dan makro terhadap tokoh kura-kura. Hasil penelitian<br />menunjukkan bahwa penulis mencampur adukan habitat, kemampuan maupun<br />bentuk dan istilah dalam cerita agar mempermudah anak-anak dalam mengenal<br />hewan yang termasuk dalam ordo Chelonians ini. Karena memang untuk<br />membedakan ketiga jenis hewan tersebut dirasa cukup sulit untuk anak kecil.</p><p>Kata Kunci: analisis wacana, makro, mikro, olah bahasa, kura-kura</p><p> </p>
Congenital Pseudarthrosis of the Tibia
Authors: O’Donnell Courtney , Foster James , Mooney Ryan , Beebe Corey , Donaldson Nathan , Heare Travis 
Published: April 2017

➢ Patients with congenital pseudarthrosis of the tibia do not have a normal tibia. In such patients, the entire tibia is abnormal (even outside of the established pseudarthrosis site); the bone does not have a normal healing response to injury or osteotomy, and the proximal growth plate typically has an abnormal inclination. Operative attempts to promote union at the pseudarthrosis site (intramedullary nailing with bone-grafting, the Ilizarov technique, and microvascular free fibular transfer) fail to address the abnormal tibia as a whole.➢ We must critically evaluate treatment outcomes for patients with congenital pseudarthrosis of the tibia; the definition of a good result must include patient-related outcome scores rather than simply radiographic union. There is need for prospective Level-I studies to compare surgical treatment options with the addition of health-related quality-of-life scores.➢ Amputation should be viewed as a viable treatment option rather than a surgical failure.➢ The achievement of a healed, straight extremity by skeletal maturity, with as few surgical procedures as possible, is essential for a child with congenital pseudarthrosis of the tibia. The extremity must be strong enough to allow the patient to function with no activity restrictions, regardless of whether the treatment course has been limb preservation or amputation.
Impact of GCM structure uncertainty on hydrological processes in an arid area of China
Authors: Fang Gonghuan , Yang Jing , Chen Yaning , Li Zhi , De Maeyer Philippe 
Published: April 2017

AbstractQuantifying the uncertainty sources in assessment of climate change impacts on hydrological processes is helpful for local water management decision-making. This paper investigated the impact of the general circulation model (GCM) structural uncertainty on hydrological processes in the Kaidu River Basin. Outputs of 21 GCMs from the Coupled Model Intercomparison Project Phase 5 (CMIP5) under two representative concentration pathway (RCP) scenarios (i.e., RCP4.5 and RCP8.5), representing future climate change under uncertainty, were first bias-corrected using four precipitation and three temperature methods and then used to force a well-calibrated hydrological model (the Soil and Water Assessment Tool, SWAT) in the study area. Results show that the precipitation will increase by 3.1%–18% and 7.0%–22.5%, the temperature will increase by 2.0 °C–3.3 °C and 4.2 °C–5.5 °C and the streamflow will change by −26% to 3.4% and −38% to −7% under RCP4.5 and RCP8.5, respectively. Timing of snowmelt will shift forward by approximately 1–2 months for both scenarios. Compared to RCPs and bias correction methods, GCM structural uncertainty contributes most to streamflow uncertainty based on the standard deviation method (55.3%) while it is dominant based on the analysis of variance approach (94.1%).