bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Eosinophilic Esophagitis in Refractory gastroesophageal reflux disease in Egyptian Patients
Authors: Hisham Basma , Gadallah Abdelnaser , Shayeb El Sayed El , Abdou Asmaa 
Published: September 2024

Abstract

Background: Gastroesophageal reflux disease (GERD) stands out as a highly common gastrointestinal ailment, marked by a variety of symptoms and lesions affecting both the esophagus and other areas, caused by the backward flow of stomach contents into the esophagus. Eosinophilic esophagitis (EoE) has emerged as an important alternative diagnosis in individuals experiencing persistent GERD symptoms. The purpose of this study is to evaluate how widespread EoE is among Egyptian patients who do not respond adequately to GERD treatments.
Esophageal tissue samples were collected from all patients exhibiting persistent GERD symptoms. EoE was diagnosed when esophageal mucosal biopsies revealed a minimum of 15 eosinophils per high-power field (HPF), along with symptoms indicating esophageal dysfunction and ruling out other causes of eosinophilia.
Results: In our latest study, we included 300 patients with persistent GERD symptoms. These patients were categorized into two groups: those diagnosed with EoE (n=12) and those without the condition (n=288). Dysphagia emerged as the predominant symptom in patients with EoE. The symptoms experienced by EoE patients closely resembled those of individuals with refractory GERD, with both groups reporting abdominal pain (100%, 87.5%) and heartburn (100%, 100%). Consequently, it is essential to conduct examinations and obtain biopsies from these patients to rule out EoE.
Conclusion: The occurrence of EoE among Egyptian patients with persistent GERD symptoms was determined to be 4%. Ie is relatively rare in individuals with refractory GERD symptoms.
Design and Psychometric Evaluation of the Nurses’ Professionalism Questionnaire (NPQ): A Sequential Exploratory Mixed-Method Study
Authors: Parastesh Sakineh , Hosseini Mohammadali , Mohammadi-Shahbolaghi Farahnaz , Ebadi Abbas , Maddah Sadat Seyyed Bagher 
Published: September 2024

Abstract

Background: With advancements in nursing tasks and technologies, the demand for professional nurses has increased, highlighting issues such as the low average of nurses' professional skills and the lack of a reliable tool to assess nurses' professional status. This study aimed to develop and psychometrically evaluate the Nurses’ Professionalism Questionnaire.
Methods: This study employed a mixed-method approach in two stages: item generation and psychometric testing. Initially, a 79-item questionnaire was developed through an integrated review of the literature and expert opinions using a directed content analysis approach. Psychometric testing included content and construct validity, reliability, interpretability, and scoring. A total of 310 nurses participated in the exploratory factor analysis phase, and 203 nurses participated in the confirmatory factor analysis phase. Data were analyzed using SPSS 21.0 and LISREL 8.8, with a significance level set at 0.05.
Results: In the primary validity assessment, 79 items were included in the initial tool. Following content and construct validity analyses, 32 items were removed, resulting in 47 items loaded onto four factors: professional competence, professional self-awareness, professional commitment and interaction, and accountability and advocacy. These factors explained 45% of the variance in professionalism. The confirmatory factor analysis model of the NPQ demonstrated a good fit. The Cronbach’s alpha and intraclass correlation coefficient (ICC) for the NPQ were 0.94 and 0.93, respectively, and the scale content validity index (S-CVI) was 0.96.
Conclusion: The NPQ is valid and reliable for evaluating nurses’ professionalism. Nursing managers and policymakers can utilize it to plan and improve nurses' professional behavior.
Integrating Mulligan Mobilization with Scapular Focused Exercises Brings Increased Benefits to Rock Climbers Suffering Shoulder Impingement Syndrome
Authors: Zanjani Bita , Shojaedin Seyed Sadredin , Abbasi Hamed 
Published: September 2024

Abstract

Background: Shoulder impingement syndrome is a prevalent condition among athletes, often resulting in decreased athletic performance due to altered proprioception, muscle imbalances, and altered movement patterns. This study aimed to investigate the effects of eight weeks of focused scapular training combined with mobilization on pain reduction and proprioception improvement in female rock climbers with shoulder impingement syndrome.
Methods: Thirty-six female rock climbers with shoulder impingement syndrome were randomly assigned to three groups: the scapular focused exercises group (n=12), the scapular focused exercises with mobilization group (n=12), and the control group (n=12). The intervention consisted of eight weeks of scapular-focused exercises, with or without mobilization, in addition to regular rock-climbing activities. Compared with those in the control group, significant reductions in pain and improvements in proprioception (joint position sense) were observed in both the scapular focused exercises and scapular focused exercises with mobilization groups (P≤0.005).
Results: The findings suggest that eight weeks of scapular-focused exercise, with or without mobilization, resulted in improved pain reduction and proprioception in female rock climbers with shoulder impingement syndrome. Compared with the control, the addition of mobilization to scapular-focused exercises resulted in better scores.
Conclusions: These results highlight the potential benefits of incorporating scapular exercises and mobilization into rehabilitation programs for athletes with shoulder impingement syndrome.
Trial registration: Retrospectively Registered. Ethics. research.ac.ir Identifier: IR.SSRC.REC.1402.170 on 2023-10-22
Inhibition of colony-stimulating factor 1 receptor improves synaptic plasticity and cognitive performance in aged mice
Authors: Strackeljan Luisa , Baidoe-Ansah David , Mirzapourdelavar Hadi , Kaushik Rahul , Cangalaya Carla , Dityatev Alexander 
Published: September 2024

Abstract

Depletion of microglia in the aged mouse brain is known to improve cognitive functions. However, even temporal ablation of microglia puts the brain at a high risk of infection. Hence, in the present work, we studied if the partial reduction of microglia with PLX3397 (pexidartinib), an inhibitor of the colony-stimulating factor 1 receptor (CSF1R), could bring similar benefits as reported for microglia ablation. Aged (two-year-old) mice were treated with PLX3397 for 28 days, which reduced microglia numbers in the hippocampus to the levels seen in young mice and resulted in layer-specific ablation in the expression of microglial complement protein C1q mediating synaptic remodeling. This treatment boosted long-term potentiation in the CA1 region and improved performance in the hippocampus-dependent novel object location recognition task. Although PLX3397 treatment did not alter the number or total intensity of Wisteria floribundaagglutinin-positive perineuronal nets (PNN) in the CA1 region of the hippocampus, it changed the fine structure of PNNs and elevated the expression of perisynaptic proteoglycan brevican, presynaptic vGluT1 and postsynaptic PSD95 proteins at the excitatory synapses in the CA1 stratum radiatum. Thus, targeting the CSF1R may provide a safe and efficient strategy to boost synaptic and cognitive functions in the aged brain.
Baseline toxicity and ovicidal action of different insecticides on new invasive insect pest into India: Fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae)
Authors: S Guruprasad G , Race Masedi O. , Guruprasad G.S. , Udikeri S.S. 
Published: September 2024

Abstract

Fall armyworm (Spodoptera frugiperda) (J.E. Smith) is a recent and invasive destructive insect pest of corn and other major crops of India; if left uncontrolled, it can destroy a crop totally. The pest carries history of resistance to many insecticides from its nativity and spread across the globe. It is likely to bear and /or develop resistance to a range of insecticides presently being used for its management in India, a possibility that has to be monitored regularly. The egg, being the first stage of the pest’s life cycle, is ideal for controlling its proliferation, and assessing the toxicity of different pesticides to eggs and larvae, and resistance, if any, to the pesticides is important for baseline studies. Accordingly, the present study assessed with common pesticides. In terms of their larvicidal action 72 h after application, chlorantraniliprole was found to be the most toxic, followed, in that order, by emamectin benzoate, flubendiamide, spinetoram, Spinosad, and azadirachtin. That order changed when the insecticides were tested for ovicidal action: thiodicarb was the most toxic, followed by spinetoram. Mortality was the highest in 3-day-old eggs, higher than that recorded in 1- or 2-day-old eggs and higher at the recommended doses than at half the recommended doses. Such differences in the target – larvae or eggs – are crucial to devising effective strategies for controlling insect pests. The strategies will be even more effective if the mechanism of action of the newer insecticides is elucidated.
A seismic damage-based design methodology for mass-eccentric moment-frame buildings
Authors: Masaeli Mohammad Ehsan , Behnamfar Farhad 
Published: September 2024

Abstract

This study is focused on developing a damage-based design procedure for torsionally coupled moment-frame structures under earthquake ground motion. The core idea is selecting a design value for the Park-Ang damage index and determining a target maximum drift ratio under torsion to be input to a displacement-based design procedure. The target drift ratio is calculated using the results of an extensive incremental dynamic analysis. In each round of analysis, the damage index and maximum drift ratio of the structure are determined as a couple. It makes it possible to derive an equation for the maximum drift ratio as a function of the damage index, by regression analysis. An almost linear relation is shown to be present between the two for the whole practical range of torsional mass eccentricity, with a very good correlation. Moment frame buildings having 5 and 10 stories, are shown to meet the sample damage index value for zero, 5 and 10 percents of eccentricity ratio.
Study of subjective well-being of diabetic patients and effect of positive psychology intervention
Authors: Xichao Xia , Jihong Wang , Jian Feng , Xiaolin Li , Yujing Zhou , Moyu Shang , Shirui Wang , Xin Li , Kaige Li , Hubin Ming 
Published: September 2024

Abstract

Background
To study of subjective well-being of diabetic patients and effect of positive psychology intervention.
Methods
The well-being of diabetic patients were analyzed by Subjective Well-being Scale. Diabetic patients were divided into control group and experimental group. Patients of control group were treated by traditional clinical care, while the experimental group with positive psychological intervention.
Results
Scores of health concerns, energy, life interest, depression control, behavior control and tension control were close associated with educational background and economic income. After positive psychological intervention, the anxiety score of intervention group was reduced by 13.43% in the intervention group. Compared with that of control group, the anxiety score decreased by 5.28% in the intervention group at the experiment end. After positive psychological intervention, the depression score decreased 10.52% in intervention group. Compared with the control group, the score of the experimental group decreased 3.49% at experiment end.
Conclusion
Well-being of diabetic patients showed different characterizations with respect of education and monthly income. Application of positive psychological interventions can result in a improving role on the anxiety and depression of diabetic patients.
Rotating Twisted Tape Turbulators and CuO Nanofluid Synergy: Investigating Heat Transfer Characteristics in Tubular Systems
Authors: KN Pavan , Kapilan N , CK Madhusudana 
Published: September 2024

Abstract

This study investigates the synergistic effect of rotating twisted tape turbulators (RTTT) and copper oxide (CuO) nanofluid on heat transfer characteristics within tubular systems with a focus on maintaining constant wall conditions. The investigation is conducted in a heat exchanger setup, where the rotating twisted tape turbulator is employed to induce turbulence and enhance heat transfer. Simultaneously, the nanofluid, consisting of 0.2% volume concentration CuO nanoparticles dispersed in a water as base fluid, is introduced to exploit the superior thermal conductivity of nanoparticles. The experimental investigation and numerical prediction encompass a comprehensive parametric study, varying rotational speeds of the twisted tape (0-300 RPM) with twist ratio (y = 2.88), 0.2% CuO nanofluid volume concentration, and varying flow rates (1–6 LPM). Heat transfer performance is assessed through measurements of temperature distribution, heat transfer coefficients, and overall thermal performance. The results reveal a significant augmentation in heat transfer efficiency attributed to the combined influence of the RTTT and 0.2% CuO NF. The synergy between the rotating twisted tape and nanofluid enhances convective heat transfer, breaking the thermal boundary layer and promoting effective heat dissipation. The limited research conducted in this area underscores the need of the rotational speed of the twisted tape and the concentration of CuO nanoparticles emerge as critical parameters influencing the heat transfer characteristics. Furthermore, the study provides insights into the interplay of fluid dynamics and thermophysical properties, shedding light on the underlying mechanisms that contribute to the observed heat transfer enhancement.
Causal relationships between basal metabolic rate and epigenetic age acceleration: bidirectional Mendelian randomization and mediation analysis
Authors: Wang Yiming , Liu Zhibing , Yu Jing , Wang YIngru , Zhang Kai , Li Jibin , Shi Dan 
Published: September 2024

Abstract

Background
Basal metabolic rate (BMR) reflecting the body's energy expenditure at rest, may be a crucial indicator of accelerated aging. However, there is a lack of evidence for the causal effect of BMR on accelerated aging. We aimed to apply Mendelian randomization (MR) and mediation analysis to explore the causal relationships between BMR and epigenetic age acceleration.
Method
Genetic variants linked to BMR and epigenetic age (GrimAge, PhenoAge, HannumAge and HorvathAge) acceleration were extracted from genome-wide association study datasets. MR analysis primarily utilizes the Inverse variance weighted (IVW), followed by a range of sensitivity analyses to validate the robustness of our findings.
Results
The univariable MR demonstrated a significant causal effect of BMR on GrimAge (IVW: Beta 0.38 [95% CI 0.12 to 0.64]), and and PhenoAge accelerations (IVW: Beta 0.91 [95%CI 0.67 to 1.45]), but not in the reverse direction. In the multivariate MR analysis adjusting for body mass index (BMI), hypertension, type 2 diabetes mellitus (T2D), physical activity, smoking, alcohol intake frequency, total and bioavailable testosterone levels, we found that the causal effects of BMR on PhenoAge and GrimAge accelerations were both dependent on BMI, and also dependent on T2D, smoking, and bioavailable testosterone levels for GrimAge acceleration. Mediation analysis indicated that 7.24%, 16.29%, 6.95%, and 5.36% of effect from BMR on GrimAge acceleration was mediated by hypertension, T2D, lack of physical activity and alcohol intake.
Conclusion
A positive and unidirectional causal effect of BMR on epigenetic age acceleration, which was dependent of BMI.
Elucidating the anti-atherosclerosis mechanism of Si Jun Zi Decoction by integrating network pharmacology and transcriptomic with experimental validation in vivo
Authors: Chen Weiyan , Ji Tianmin , Yang Ying , Zhao Zhuo , Gao Hao , Zhou Lijiang , Wang Ying 
Published: September 2024

Abstract

Objective: Sijunzi Decoction (SJZD) is a kind of traditional Chinese medicine (TCM) formula,which has the contribution to anti-atherosclerosis.This study aims to explore the potential mechanism of the treatment of atherosclerosis (AS) with SJZD.
Methods: Comprehensive analysis with transcriptomics and network pharmacology,combining with in vivo experiment and therapeutic targets.
Results: Through the in vivo experiment,it was found that SJZD could significantly improve the blood lipid level and lipid deposition in ApoE−/− mice.Furthermore,4 biological processes(lipid localization,specific granule,positive regulation of lipid localization,positive regulation of lipid transport),7 targets (SPP1,EGF,OLR1,LDLR,PON1,SLP1,PLAU), and 6 active ingredients(including beta-sitosterol,kaempferol,quercetin,stigmasterol, naringenin and isorhamnetin) play an extremely important role in the treatment of AS with SJZD.We also found that the genes of OLR,SPP1 and EGF were involved in regulating oxidative stress during the progress of atherosclerosis and the improvement of endothelial dysfunction.Furthermore,SJZD could interfere the expression of mRNA and protein of OLR1,SPP1 and EGF,and respectively reduce and increase the density level of MDA and SOD in serum significantly.
Conclusion:Inhibiting excessively oxidative stress and improving endothelial dysfunction by regulating OLR1/SPP1/EGF pathway could be the mechanism,by which Sijunzi decoction resists AS.
Effects of Dietary Zinc Alginate Complex Supplementation on Growth Performance, Nutrient Utilisation ,Tibia bone characteristics, Ileum morphology, Carcass characteristics, Meat quality and Footpad Health in Broiler Chicken
Authors: Selvapandian Sridhar , N Muthusamy , C Kathirvelan , G Kumaresan , P Vasanthakumar , R.P Senthilkumar 
Published: September 2024

Abstract

A biological trial was carried out with 256 numbers of sex-separated day-old broiler chicks distributed to four experimental groups with eight replicates, each replicate consisting of eight chicks. The experimental basal diet supplemented with zinc oxide (T1) at 80 ppm and three levels of zinc alginate complex at 56,45 and 34 ppm were designated as dietary treatments (T2, T3 and T4). At the end of 35 days T4, T3 and T2 groups had significantly (P < 0.01) higher body weight and FCR compared to the zinc oxide group and average daily feed intake (g/bird) was comparable among the zinc alginate complex groups and the zinc oxide-supplemented group. The tibial zinc was significantly (P < 0.01) increased with a low level of inclusion of zinc alginate complex compared to the zinc oxide group. However, serum zinc was not statistically significant, but the lower inclusion of zinc alginate complex at 34 ppm had numerically higher serum zinc concentration than the zinc oxide group. The zinc alginate complex at 34 ppm and 56 ppm significantly (P < 0.05) increased the dry matter digestibility and crude protein digestibility. At 34 ppm and 45 ppm significantly (P > 0.05) increased tibial bone length. The ileal villi height and ileal villi height to crypt depth ratio (VH: CD) were significantly (P < 0.01) increased in the zinc alginate complex. Overall, these findings underscore the potential benefits of zinc alginate complex in enhancing nutrient utilization, and growth performance in poultry farming.
Unexpected Winners of Climate Change: The Rise of Mosses
Authors: ERATA Hüseyin , KIRAÇ Akın , BATAN Nevzat 
Published: September 2024

Abstract

This study investigates the impact of climate change on the geographic distribution and ecological roles of terrestrial mosses. Given their remarkable adaptability, we anticipate that climate change will enable terrestrial mosses to expand across a wider geographic range. Mosses possess a remarkable ability to withstand dehydration and quickly resume the process of photosynthesis, which allows them to thrive and adapt effectively in the face of fluctuating climatic conditions. Mosses also have a significant impact on ecosystem equilibrium. Their crucial function in the global carbon cycle is defined by their ability to sequester carbon, particularly in places dominated by mosses such as peatlands. This study demonstrates that land mosses have the capacity to fulfill a crucial function in maintaining ecosystem sustainability and managing carbon levels in the face of climate change. Mosses could potentially restore the vigor and variety lost due to climate change, thereby restoring everything to its previous state.
The effectiveness of biotin in therapy alopecia of various origins, pathologies of the skin and nails
Authors: Torshin I. Yu. , Gromova O. A. 
Published: September 2024

Biotin deficiency is caused by inflammatory bowel diseases that impair the absorption of the vitamin, special dietary disorders with the consumption of raw eggs (excess avidin – a vitamin B7 blocker protein), magnesium deficiency, smoking, alcohol, treatment with broad-spectrum antibiotics, sulfonamides, and anticonvulsants. Hypovitaminosis B7 has also been noted in individuals with congenital genetic defects of the biotinidase gene or other genes involved in biotin metabolism. Deficiency of water-soluble vitamin B7 (vitamin H) – manifested by dry skin, seborrheic dermatitis, dermatitis around the eyes, nose, mouth, ears and groin, impaired nail growth, slow healing of skin cuts, atopic dermatitis, striations, splitting, brittle nails and alopecia (diffuse and androgenic form). Alopecia occurs when hair follicles die and leads to hair loss. The human proteome contains 51 proteins involved in biotin metabolism. In particular, D-biotin-dependent carboxylases play an important role in the metabolism of fatty acids, amino acids, carbohydrates, cell division and growth, incl. keratinocytes and hair follicle cells. The molecular mechanisms of the effects of D-biotin on the skin and its appendages may involve various growth factors: regulation of the signaling pathways of growth factors (IGF-1, FGF, KGF, HGF, VEGF, SIRT-1, Wnt and beta-catenin) has been shown. Hair follicle stem cells cause the cyclical growth of hair follicles. Growth factors are involved in the activation of stem cell growth by D-biotin; activation of the Wnt/β-catenin signaling cascade leads to the activation of cyclin D1 proteins (initiates DNA synthesis and leads to increased viability of hair follicles. The results of fundamental and clinical studies confirm the prospects of using biotin in dermatology for the treatment of diseases of the skin, hair and nails, incl. alopecia of various origins (androgenic, focal, diffuse). The results of the studies indicated that biotin was well tolerated, and there was no risk of hypervitaminosis even when taking megadoses (hundreds of milligrams).