bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rituximab for Recurrence of Primary Focal Segmental Glomerulosclerosis After Kidney Transplantation: Clinical Outcomes
Authors: Garrouste Cyril , Canaud Guillaume , Büchler Mathias , Rivalan Joseph , Colosio Charlotte , Martinez Frank , Aniort Julien , Dudreuilh Caroline , Pereira Bruno , Caillard Sophie , Philipponnet Carole , Anglicheau Dany , Heng Anne Elisabeth 
Published: April 2016

Background
Rituximab has shown encouraging results for the treatment of kidney transplantation recipients with focal segmental glomerulosclerosis (FSGS) recurrence. However, the correct, opportune, and safe use of rituximab for this indication remains to be determined.

Methods
This multicenter retrospective study reports on 19 new cases aged 35 (15-66) years who developed FSGS recurrence at 12 (1.5-27) days posttransplantation. Initial treatment consisted of plasma exchanges (PE), high doses of calcineurin inhibitors, and steroids. Rituximab was introduced either immediately (N = 6) or after failure of the initial treatment (N = 10) or failed attempted weaning from PE (N = 3).

Results
Overall, we observed 9 of 19 complete remissions and 3 of 19 partial remissions. Estimated glomerular filtration rates (Modification of Diet in Renal Disease 4) were significantly higher in the responding patients than in nonresponding patients at month (M)12, M36, and M60. Overall, kidney survival at 5 years was 77.4% (95% range, 41.9-92.7). The 5-year graft survival rates in the responding patients and the nonresponding patients were 100% and 36.5%, respectively (P = 0.01). A further course of rituximab was required for 4 patients as a result of FSGS relapse, with good results. During the first year after renal transplantation, 14 patients developed severe infections (16 bacterial, 4 viral, 1 parasitic).

Conclusions
In kidney transplantation recipients with recurrent FSGS, rituximab therapy may be a recommended treatment for cases that have failed either the initial treatment or weaning from PE.
Summertime Dyskinesia-Hyperpyrexia Syndrome: The “Dual Heat” Hypothesis
Authors: Herreros-Rodriguez Jaime , Sánchez-Ferro Álvaro 
Published: April 2016

Abstract
The dyskinesia-hyperpyrexia syndrome is a rare complication of Parkinson disease. Here, we present an exceptional case affected by this syndrome. Its singularity is 2-fold. On one hand, the patient presented periodic episodes of dyskinesia-hyperpyrexia during 3 consecutive summers. On the other, after unsuccessfully trying several therapies, she had an excellent response to an infusion of enteral L-dopa. Both features allow us to hypothesize that this complication is central in origin and propose a new potential mean of treating future refractory cases.
Chm7 and Heh1 form a nuclear envelope subdomain for nuclear pore complex quality control
Authors: Webster Brant M. , Thaller David J. , Jäeger Jens , Ochmann Sarah E. , Lusk C. Patrick 
Published: April 2016

AbstractMechanisms that ensure the integrity of the nuclear envelope rely on membrane remodeling proteins like the ESCRTs and the AAA ATPase Vps4, which help seal the nuclear envelope at the end of mitosis and prevent the formation of defective nuclear pore complexes (NPCs). Here, we show that the integral inner nuclear membrane proteins Heh1 and Heh2 directly bind the ESCRT-III, Snf7, and the ESCRT-II/III chimera, Chm7, in their ‘open’ forms. Moreover, Heh1 is required for Chm7-recruitment to the nuclear envelope. As Chm7 accumulates on the nuclear envelope upon blocks to NPC assembly, but not to nuclear transport, interactions between ESCRTs and the Heh proteins might form a biochemically distinct nuclear envelope subdomain that delimits regions of assembling NPCs. Interestingly, deletion ofCHM7suppresses the formation of the storage of improperly assembled NPC compartment prevalent invps4Δstrains. Thus, our data support that the Heh1-dependent recruitment of Chm7 is a key component of a quality control pathway whose local regulation by Vps4 and the transmembrane nup, Pom152, prevents loss of nuclear compartmentalization by defective NPCs.
Heat*seq: an interactive web tool for high-throughput sequencing experiment comparison with public data
Authors: Devailly Guillaume , Mantsoki Anna , Joshi Anagha 
Published: April 2016

SummaryBetter protocols and decreasing costs have made high-throughput sequencing experiments now accessible even to small experimental laboratories. However, comparing one or few experiments generated by an individual lab to the vast amount of relevant data freely available in the public domain might be limited due to lack of bioinformatics expertise. Though several tools, including genome browsers, allow such comparison at a single gene level, they do not provide a genome-wide view. We developed Heat*seq, a web-tool that allows genome scale comparison of high throughput experiments (ChIP-seq, RNA-seq and CAGE) provided by a user, to the data in the public domain. Heat*seq currently contains over 12,000 experiments across diverse tissue and cell types in human, mouse and drosophila. Heat*seq displays interactive correlation heatmaps, with an ability to dynamically subset datasets to contextualise user experiments. High quality figures and tables are produced and can be downloaded in multiple formats.AvailabilityWeb application:www.heatstarseq.roslin.ed.ac.uk/. Source code:https://github.com/gdevailly.ContactGuillaume.Devailly@roslin.ed.ac.uk;Anagha.Joshi@roslin.ed.ac.uk
How do idiosyncratic deals contribute to the employability of older workers?
Authors: Oostrom Janneke K. , Pennings Martine , Bal P. Matthijs 
Published: April 2016

Purpose– The purpose of this paper is to examine the relationships of i-deals with the employability of older workers, and introduce two distinct theoretical processes through which these effects occur. On the one hand, a self-enhancement perspective postulates that i-deals enhance self-efficacy through which older workers become more employable. On the other hand, a lifespan perspective postulates that i-deals enhance older workers’ future time perspective through which they become more employable.Design/methodology/approach– Data were gathered among 244 employees via an online questionnaire that had been sent to employees of 45 years or older at eight companies in the Netherlands.Findings– Results showed that task and work responsibilities i-deals are strongly related to older workers’ employability, and that this relationship is mediated by future time perspective and self-efficacy. Location flexibility i-deals were positively related to employability. Financial i-deals and schedule flexibility i-deals were unrelated to employability.Research limitations/implications– This study introduces two novel ways through which i-deals for older workers can be studied: a self-enhancement and a future time perspective. Both can explain how older workers may enhance their employability by negotiating i-deals.Practical implications– As the percentage of older workers will increase, there is a great need for organizations to focus on the employability of older workers. The present study shows that organizations are able to increase the employability of older workers by individual arrangements.Originality/value– Individualization of work arrangements has been theorized to facilitate older workers’ employability, but the present study is the first to investigate how i-deals may contribute to greater employability.
School leadership styles among educators in Abu Dhabi
Authors: Litz David , Juma Qusay Abu , Carroll Kevin S. 
Published: April 2016

Purpose– The purpose of this paper is to report on an examination of the perceptions of two principals and two lead teachers regarding their own leadership styles, including how they define and perform their roles as leaders.Design/methodology/approach– The research employed a case study design whereby two principals and two lead teachers (one of each from a government school (GS) and a private school in Abu Dhabi UAE) were interviewed over the course of one semester.Findings– Results suggest that the two principals viewed themselves as succeeding in six domains – school climate, school leadership, personnel management, administration and school management, student management, and relationships with parents and the community – but that they desired to improve with regard to curriculum development and professional and in-service development. The two lead teachers primarily defined their leadership roles as providing assistance to others and modeling best practice and flexibility, and considered themselves bridges between other teachers and the administration, as well as task facilitators and task achievers.Originality/value– The paper reveals that both principals and teachers in Abu Dhabi engage in a number of activities consistent with much of the literature on effective school leadership styles. However, the findings also shed light on several marked differences between private and GSs in the Emirate, a lack of genuine collaboration between principals and teachers, and possible constraints on school leadership caused by top-down administrative practices.
Entrepreneurship and liminality: the case of self-storage based businesses
Authors: Daniel Elizabeth , Ellis-Chadwick Fiona 
Published: April 2016

Purpose– The purpose of this paper is to apply the theoretical lens of liminality to a consideration of non-traditional entrepreneurial locations. The study exemplifies such locations by empirically exploring self-storage based businesses: that is, businesses that operate for a significant number of hours each week from self-storage facilities.Design/methodology/approach– The study draws on interviews with entrepreneurs operating self-storage based businesses and operators of self-storage facilities. The interview data is supported by site visits, businesses’ websites, promotional and marketing materials and press coverage.Findings– Consistent with the liminal lens, entrepreneurs view their time operating from self-storage as a transitional phase. They do not suffer the high levels of uncertainty and unsettledness usually associated with liminality. However, they experience anxiety related to perceptions of operating from a business location outside the mainstream. Whilst the entrepreneurs benefit from additional services provided by the self-storage operators, this may be at the expense of extra “liminal” work and anxiety experienced by the storage operators’ staff.Originality/value– The study contributes to entrepreneurship by answering Steyaert and Katz’s (2004) call for studies in unfamiliar places and spaces. The authors identify a number of ways in which liminality can arise when considering entrepreneurial locations. Drawing on extant entrepreneurial studies, the authors theorise that idiosyncratic characteristics of such spaces attract entrepreneurs with particular personal characteristics and needs, who will in turn be influenced by those spaces. In the case of self-storage facilities, the liminal space allows trepidatious entrepreneurs to “try on” (Hawkins and Edwards, 2015, p. 39) operating a new venture.
The effect of gaze on consumers’ encounter evaluation
Authors: Andersson Pernille , Wästlund Erik , Kristensson Per 
Published: April 2016

Purpose
– The research concerns the effect of frontline employees’ averted or direct gaze on consumers’ evaluation of the encounter. The purpose of this paper is to demonstrate that in normal interactions, a direct or averted gaze affects people’s evaluation of others. The question was whether this finding would hold true in commercial interactions.

Design/methodology/approach
– The authors conducted three experiments using a written scenario with a photograph among a total sample of 612 participants.

Findings
– This research showed that consumers’ social impression of the frontline employees mediated the effect of the employees’ gazing behaviour on consumers’ emotions and satisfaction with the encounters. The findings also showed that averting gaze had a negative effect on consumers’ first impression of the frontline employee, which affected consumers’ satisfaction with the encounter. The findings also showed that a direct gaze had a negative effect on encounter satisfaction when consumers sought to purchase embarrassing products.

Originality/value
– The research demonstrated that the effect of gaze on encounter satisfaction was mediated by the social impression and moderated by consumers’ approach/avoidance motivation.
International firms in Africa’s food retail business-emerging issues and research agenda
Authors: Nandonde Felix Adamu , Kuada John 
Published: April 2016

Purpose
– The purpose of this paper is to describe the state of the retail sector in Sub-Saharan Africa, to point out the lack of information on some critical issues and to raise some questions about relevant topics for researchers and practitioners in the retail area for the African market.

Design/methodology/approach
– This paper is comprised of a comprehensive review of the literature and integrates the fragmented body of knowledge on the area of retail internationalisation and food marketing. The gaps in the literature identified here may help to understand the sector better and develop academic research agendas on both the growth of the modern food retail sector and the agribusiness sector in Africa.

Findings
– Four major topics were identified in the urban agri-food retail business in the African continent: large global retailers in Africa’s food sector; the internationalisation of African food retailers; the procurement practices of international retailers; and, the food-buying behaviour of Africa’s middle class.

Originality/value
– This research paper relied heavily on grey literature such as newspapers and unpublished masters’ dissertations and PhD theses. With this material as a context, this paper provides guidance as to how scholars can advance the study of retail internationalisation in Africa, not only through further empirical and conceptual research but also by developing usable prescriptions for agribusiness value-chain actors on the continent.
Impact of core product quality on sport fans’ emotions and behavioral intentions
Authors: Foroughi Behzad , Nikbin Davoud , Hyun Sunghyup Sean , Iranmanesh Mohamad 
Published: April 2016

Purpose– The purpose of this paper is to examine the relationships among the core product quality (team characteristics and player performance), emotion (anxiety, anger, dejection, happiness, and excitement), and the fans behavioral intentions.Design/methodology/approach– Data were gathered on the team characteristics and player performance, emotions of anxiety, anger, dejection, happiness, and excitement using a survey from subjects comprised of 233 spectators attending Iranian Premier League soccer matches.Findings– The results showed that both the core product quality dimensions of the team characteristics and player performance are related significantly to the negative emotion of anxiety and both positive emotions of excitement and happiness. Moreover, the positive emotions of excitement and happiness were positively related to the fan attendance, while the negative emotions of anxiety and dejection were negatively and significantly related to the fans behavioral intentions. The practical implications of the findings are discussed briefly.Originality/value– The paper provides useful information for sports marketing executives, suggesting that they strive for unique organizational advantages and employ them in their marketing messages when their teams are unsuccessful. Such a strategy can allow organizations to maximize the positive emotions of spectators in the face of poor core product quality.
Data reliability in citizen science: learning curve and the effects of training method, volunteer background and experience on identification accuracy of insects visiting ivy flowers
Authors: Ratnieks Francis L. W. , Schrell Felix , Sheppard Rebecca C. , Brown Emmeline , Bristow Oliver E. , Garbuzov Mihail 
Published: April 2016

Summary

Citizen science, the involvement of volunteers in collecting of scientific data, can be a useful research tool. However, data collected by volunteers are often of lower quality than those collected by professional scientists.

We studied the accuracy with which the volunteers identified insects visiting ivy (Hedera) flowers in Sussex, England. In the first experiment, we examined the effects of training method, volunteer background and prior experience. Fifty‐three participants were trained for the same duration using one of three different methods (pamphlet, pamphlet + slide show or pamphlet + direct training). Almost immediately following training, we tested the ability of the participants to identify live insects on ivy flowers to one of 10 taxonomic categories and recorded whether their identifications were correct or incorrect, without providing feedback.

The results showed that the type of training method had a significant effect on identification accuracy (P = 0·008). Participants identified 79·1% of insects correctly after using a one‐page colour pamphlet, 85·6% correctly after using the pamphlet and viewing a slide show and 94·3% correctly after using the pamphlet in combination with direct training in the field.

As direct training cannot be delivered remotely, in the following year we conducted a second experiment, in which a different sample of 26 volunteers received the pamphlet plus slide show training repeatedly three times. Moreover, in this experiment, participants received c. 2 min of additional training material, either videos of insects or stills taken from the videos. Testing showed that identification accuracy increased from 88·6% to 91·3% to 97·5% across the three successive tests. We also found a borderline significant interaction between the type of additional material and the test number (P = 0·053), such that the video gave fewer errors than stills in the first two tests only.

The most common errors made by volunteers were misidentifications of honeybees and social wasps with their hover fly mimics. We also tested six experts who achieved nearly perfect accuracy (99·8%), which shows what is possible in practice.

Overall, our study shows that two or three sessions of remote training can be as good as one of direct training, even for relatively challenging taxonomic discriminations that include distinguishing models and mimics.
History and development of an isolated outbreak ofAsian longhorn beetleAnoplophora glabripennis(Coleoptera:Cerambycidae) in southernEngland
Authors: Straw Nigel A. , Fielding Nick J. , Tilbury Christine , Williams David T. , Cull Thomas 
Published: April 2016

AbstractAsian longhorn beetleAnoplophora glabripennisis a major international quarantine pest that is capable of killing a wide range of broadleaved trees. In 2012, an outbreak ofA. glabripenniswas discovered atPaddockWood in southernEngland, which prompted an eradication programme and research to determine when the population had established, as well as how quickly it was spreading.Tree ring analysis of infested stems and branches showed that the firstA. glabripennisadult emerged in 2003 and that the beetle had been present for approximately 10 years before it was discovered. However, the population had increased relatively slowly and, even though it could be shown that some beetles travelled 96–203 m to lay eggs in new trees, the population as a whole had not spread further than 234 m.Survival rates of larvae were similar to rates observed in otherA. glabripennispopulations, although failure at the egg‐laying stage and adult mortality at or before emergence were higher than recorded elsewhere.A combination of factors appears to have allowedA. glabripennisto establish atPaddockWood: the presence of a highly susceptible host (sycamore), multiple introductions of adult beetles over several years, and a run of warmer than average summers at the time of the initial colonization.
Prospective evaluation of the utility of routine neuromonitoring for an established thyroid surgical practice
Authors: Lee Jane , Fraser Sheila , Glover Anthony , Sidhu Stan 
Published: April 2016

BackgroundThe use of routine intraoperative neuromonitoring (IONM) is controversial in thyroid surgery. Guidelines have been published to standardize IONM. This study examines the impact of routine IONM on a high‐volume thyroid surgeon.MethodsA prospective study was conducted using IONM between May 2013 and December 2014. Demographics, type of operation, pathology, recurrent laryngeal nerve (RLN) and external branch of the superior laryngeal nerve (EBSLN) visualization and sub‐type classification, cricothyroid or cricopharyngeal twitch/electrode depolarization were obtained, and complications were recorded. Outcomes were compared with 500 thyroidectomies performed by the same surgeon without neuromonitoring.ResultsTwo hundred and ninety‐nine total thyroidectomies and 191 hemithyroidectomies were performed with IONM resulting in 789 RLN and 789 EBSLN at risk of injury. Demographics, indication, pathology and complications were similar between the two groups. IONM provided additional information for 58 RLN dissections (7.4%) stratifying surgical decision‐making. Loss of signal was detected in 1.8% of nerves at risk. IONM assisted in identification of 109 (13.8%, P < 0.0001) EBSLN, including a 15.8% improvement in identifying type 2b EBSLN. Utility of IONM was not predicted by surgery indication; however, multinodular goitre was a significant predictor of IONM assisted identification of type 2b EBSLN (OR = 2.24, P = 0.01).ConclusionRoutine IONM provides intraoperative information to a high‐volume thyroid surgeon regarding the recurrent and external nerves over and above direct visualization alone, and its utility could not be predicted by operative indication.
Incidence, clinical presentation and mortality of liver cirrhosis in Southern Sweden: a 10‐year population‐based study
Authors: Nilsson E. , Anderson H. , Sargenti K. , Lindgren S. , Prytz H. 
Published: April 2016

SummaryBackgroundIn Sweden, the most common causes of liver cirrhosis are alcohol overconsumption and hepatitis C. However, recent data on the clinical characteristics of Swedish patients with cirrhosis are scarce.AimsTo determine the incidence, clinical presentation, aetiological spectrum and survival rates of liver cirrhosis in Southern Sweden from 2001 to 2011.MethodsWe used population‐based medical registries to conduct a cohort study of all patients with liver cirrhosis in the southernmost region of Sweden with a population of 1.17 million. Medical records and histopathology data were reviewed. Patients were classified according to aetiology, and clinical parameters were registered. Patients were followed until death or December 2014.ResultsA total of 1317 patients with cirrhosis were identified. The crude annual incidence of cirrhosis was estimated at 14.1/100 000. The most common aetiology was alcohol overconsumption with or without additional causes of cirrhosis (58%) followed by HCV alone (13%) and cryptogenic cirrhosis (12%). At diagnosis, ascites occurred in 43%, variceal bleeding in 6% and overt encephalopathy in 4%. The median follow‐up was 4.3 years. The total 1‐, 5‐ and 10‐year survival rates were 79%, 47% and 27% respectively. Survival rates were better for women than for men. A 10‐year cumulative incidence of transplantation was 7.3%. Mortality was worst for alcoholic cirrhosis with concomitant HCV when adjusted for age and gender.ConclusionsSweden continues to have a low incidence of cirrhosis compared with other European countries. Mortality varies with gender, aetiology and severity at diagnosis. Patients with alcoholic cirrhosis with concomitant HCV infection fare worst.