bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pasireotide: successful treatment of a sparsely granulated tumour in a resistant case of acromegaly
Authors: Amarawardena W K M G , Liyanarachchi K D , Newell-Price J D C , Ross R J M , Iacovazzo D , Debono M 
Published: July 2017

Summary
The granulation pattern of somatotroph adenomas is well known to be associated with differing clinical and biochemical characteristics, and it has been shown that sparsely granulated tumours respond poorly to commonly used somatostatin receptor ligands (SRLs). We report a challenging case of acromegaly with a sparsely granulated tumour resistant to multiple modalities of treatment, ultimately achieving biochemical control with pasireotide. A 26-year-old lady presented with classical features of acromegaly, which was confirmed by an oral glucose tolerance test. Insulin-like growth factor 1 (IGF1) was 1710 µg/L (103–310 µg/L) and mean growth hormone (GH) was >600 U/L. MRI scan showed a 4 cm pituitary macroadenoma with suprasellar extension and right-sided cavernous sinus invasion. She underwent trans-sphenoidal pituitary surgery. Histology displayed moderate amounts of sparsely granular eosinophilic cytoplasm, staining only for GH. Postoperative investigations showed uncontrolled disease (IGF1:1474 µg/L, mean GH:228 U/L) and residual tumour in the cavernous sinus. She received external beam fractionated radiation. Over the years, she received octreotide LAR (up to 30 mg), lanreotide (up to 120 mg) two weekly, cabergoline, pegvisomant and stereotactic radiosurgery to no avail. Only pegvisomant resulted in an element of disease control; however, this had to be stopped due to abnormal liver function tests. Fifteen years after the diagnosis, she was started on pasireotide 40 mg monthly. Within a month, her IGF1 dropped and has remained within the normal range (103–310 µg/L). Pasireotide has been well tolerated, and there has been significant clinical improvement. Somatostatin receptor subtyping revealed a positivity score of two for both sst5 and sst2a subtypes.

Learning points:

Age, size of the tumour, GH levels on presentation, histopathological type and the somatostatin receptor status of the tumour in acromegaly should be reviewed in patients who poorly respond to first-generation somatostatin receptor ligands.

Tumours that respond poorly to first-generation somatostatin receptor ligands, especially sparsely granulated somatotroph adenomas, can respond to pasireotide and treatment should be considered early in the management of resistant tumours.

Patients with membranous expression of sst5 are likely to be more responsive to pasireotide.
Integrated GIS Based Approach in Mapping Groundwater Potential Zones in Kota Kinabalu, Sabah, Malaysia
Authors: Isnain Zulherry , Akhir Juhari Mat 
Published: July 2017

DOI: 10.17014/ijog.4.2.111-120The shortage of clean water occurs almost everywhere around the world. The demand for water supply increases from time to time due to various problems such as development, population growth, pollution, global warming, agricultural activities, logging, and so on. This study was conducted in the vicinity of Kota Kinabalu, Sabah, by using the Geographic Information System (GIS) for mapping the groundwater potential zones. The main objective of this study was to generate the predictive map of groundwater potential zones in the studied area through the integration of various thematic maps by using the GIS. This study includes five stages, namely collection and preparation of basic data, data analyses, development of space database, spatial analyses, and space integration. There are eleven parameters used in this study, namely rainfall, drainage, soil type, landuse, lithology, lineament density, topography, slope steepness, the ratio of sand and clay, major fault zones, and syncline zones. By using the Heuristic method, the final map of groundwater potential zones in the studied area is divided into five classes, which are very low, low, moderate, high, and very high.
Salivary Levels of NLRP3 Inflammasome‐Related Proteins as Potential Biomarkers of Periodontal Clinical Status
Authors: Isaza‐Guzmán Diana M. , Medina‐Piedrahíta Verónica M. , Gutiérrez‐Henao Carolina , Tobón‐Arroyave Sergio I. 
Published: July 2017

Background: Emerging evidence suggests that activation of inflammasomes plays a central mechanism in pathogenesis of periodontitis. This study aims to compare salivary levels of nod‐like receptor family pyrin domain containing protein (NLRP) 3, apoptosis‐associated speck‐like protein containing a caspase recruitment domain (ASC), cysteine aspartase (caspase)‐1, and interleukin (IL)‐1β from individuals with aggressive (AgP) or chronic periodontitis (CP) and healthy controls (HC), as well as elucidate its association with periodontal clinical status.Methods: Saliva samples from individuals with CP (n = 75), AgP (n = 20), and HC (n = 69) were collected. Periodontal status was assessed by measurement of probing depth, clinical attachment level, and extent and severity of disease. Salivary levels of analytes were analyzed by enzyme‐linked immunosorbent assay. Association between biomarkers with CP or AgP was analyzed using multivariate binary logistic regression models.Results: Significantly higher levels of NLRP3, ASC, and IL‐1β were detected in periodontitis groups in comparison to the periodontally HC group. However, no significant differences were observed for caspase‐1 levels between clinical groups, and only NLRP3 salivary concentration was significantly higher in AgP compared with CP patients. Also, positive significant correlations among NLRP3, ASC, and IL‐1β salivary concentrations and clinical parameters were observed. Logistic regression analyses revealed a strong/independent association of NLRP3, ASC, and IL‐1β salivary levels with CP and AgP.Conclusion: Although the concentration of caspase‐1 in saliva samples makes its determination useless for detection of periodontal disease and/or its severity, salivary levels of NLRP3, ASC, and IL‐1β may act as strong/independent indicators of amount and extent of periodontal breakdown in both CP and AgP and could potentially be used for prevention and therapy of this group of diseases.
EFFECTS OF WHOLE BODY VIBRATION INTERVENTION ON HANDGRIP STRENGTH OF BRAZILIAN HEALTHY SOLDIERS
Authors: Morel Danielle Soares , Moreira-Marconi Eloá , Sobrinho Neto Samuel Brandão , Domingos Laisa Liane Paineiras , Souza Patrícia Lopes de , Sá Caputo Danúbia da Cunha de , Costa Glenda Dias , De Figueiredo Cláudia Ferreira , Resende Carmo Roberto Carlos , De Paiva Patrícia de Castro , Sousa Gonçalves Cintia Renata , Kütter Cristiane Ribeiro , De Aguiar Eliane de Oliveira Guedes , Bernardo-Filho Mario 
Published: July 2017

Background: Whole body vibration (WBV) exercises have been investigated as an alternative and complementary
method to traditional resistance programs for fitness improvements in healthy subjects. Active militaries must have a
high fitness level and have to improve some physical abilities to accomplish some specific tasks in Army, as climb
ropes, climb walls and pull up.
Materials and methods: Seven young and healthy soldiers from Brazilian Army were exposed to mechanical vibration
in a push-up position, with different frequencies, as 25 (first session), 30 (second session), 35 (third session), 40 (fourth
session) and 45 Hz (fifth session). The WBV intervention consisted of five WBV sessions over a consecutive two and a
half-weeks period of time. A WBV session consisted of twenty bouts, each one with 10- second vibration, interspersed
with 10 seconds of passive rest and 4 minutes pause after the first 10 bouts. Handgrip strength was measured, as
proposed by American Society of Hand Therapists – ASHT, before and after the session using 25 Hz of frequency and
45 Hz of frequency (1st and 5th sessions).
Results: No significant results were found between groups.
Conclusion: Intervention of WBV exercises with 25 and 45 Hz of frequency applied by hands of healthy and young
soldiers had no significant results. Further investigations should focus on the efficacy of WBV in the improvement of
handgrip strength of young and healthy people.
Use of Nickel Nanoparticles for Promoting Aquathermolysis Reaction During Cyclic Steam Stimulation
Authors: Yi Siyuan , Babadagli Tayfun , Andy Li Huazhou 
Published: July 2017

Summary
Late cycles of cyclic steam stimulation (CSS) are characterized by a decreasing heavy-oil recovery and an increasing water cut. Nickel nanoparticles can be used to promote aquathermolysis reactions between water and heavy oil in steam-injection processes, thereby increasing the recovery factor (RF). In this paper, detailed investigations were performed to determine the optimal operational parameters and answers to the following questions:
What is the optimal concentration of nickel nanoparticles for promoting aquathermolysis under high steam temperature? Can we improve oil recovery at lower steam temperatures with the presence of nickel nanoparticles? What effect does the penetration depth of nickel nanoparticles have on the final oil recovery?
CSS experiments were conducted between temperatures of 150 and 220°C. Steam generated under these temperatures was injected into sandpacks saturated with Mexican heavy oil. Powder-form nickel nanoparticle was introduced into this process to boost the oil production. In an attempt to obtain the optimal concentration, different concentrations were tested. Next, oil sands without any nanoparticle additives were first added into the cylinder. Then, only one-third of the sandpack was mixed with nickel nanoparticles near the injection port. Experiments were executed to study the effects of temperature, nickel concentrations, and nanoparticle-penetration depth on the ultimate oil recovery and produced oil/water ratios after each cycle. Produced-oil quality and emulsion formation were evaluated with gas-chromatography (GC) analysis, viscosity measurements, saturates/asphaltenes/resins/aromatics (SARA) tests, and microscopic analysis of the effluents.
Experimental results show that the best concentration of nickel nanoparticles, which gives the highest ultimate oil RF, is 0.20 wt% of initial oil in place (IOIP) under 220°C, whereas the nickel concentration of 0.05 wt% provides the highest RFs at the early stages. A lower temperature of 150°C provides a much-lower RF than 220°C, which is mainly because of a lower level of aquathermolysis reactions at 150°C. By analyzing the compositions of produced oil and gas samples with GC and SARA tests, we confirm that the major reaction mechanism during the aquathermolysis reaction is the breakage of the carbon/sulfur (C/S) bond; the nickel nanoparticles can act as catalyst for the aquathermolysis reaction; and the catalytic effect becomes less remarkable from cycle to cycle. One run of the experiment to test the effect of particle-penetration depth revealed that the nickel nanoparticles distributed near the injection port greatly contributed to the ultimate RF.
Echocardiographic assessment of right ventricle diastolic function in patients with multivessel coronary artery disease
Authors: Sinelnikov Yu. , Orekhova E. , Osetrova O. , Balyshova O. 
Published: July 2017

Aim. The study was aimed at assessing the right ventricle diastolic function in patients with multivessel coronary artery disease.Methods. 62 patients (32 males (51.6 %)) with multivessel coronary artery disease (SYNTAX Score 33.04±4.1) were examined over a period from 2014 to 2016. The mean age was 58.5±8.3 years). To examine the diastolic function of the left and right ventricles (LV, RV), conventional echocardiographic (EchoCG) parameters, as well as a longitudinal diastolic strain rate at the level of RV free wall segments were analyzed by using tissue Doppler imaging in 2D strain imaging mode.Results. The systolic function of both ventricles was moderately decreased (LV EF 43.2 ± 5.5%, RV EF 42±6 %). 41 patients (66.1 %) demonstrated LV diastolic dysfunction (DD, impaired relaxation) of grade I and 46 patients (74.2 %) – RV DD of grade I. Pseudonormal LV DD grade II was revealed in 18 patients (29 %) and RV DD of grade II – in 15 patients (24.2 %). 3 patients (4.8 %) had LV DD (restrictive) of grade III and only 1 patient (1.6 %) showed a restrictive type of RV filling. The early diastolic strain rate (ESR) was 0.86±0.18 s–1 in patients with DD of grade I, the late diastolic strain rate was 0.88±0.27 s–1 (ASR), with their ratio ESR / ASR running to 0.99±0.16. For patients with DD of grade II, ESR was 0.62±0.04 s–1, ASR – 0.41±0.04 s–1 and the ratio of ESR / ASR – 1.5±0.19. For patients with DD of grade III (n = 1), ESR was 0.41 s–1, ASR – 0.2 s–1 and the ratio ESR / ASR – 2.05. A significant inverse correlation between the coronary artery disease complexity (SYNTAX Score) and the strain rate in the early diastolic phase of RV filling ESR (RS = –0.73, p = 0.001) was identified.Conclusion. Longitudinal systolic strain and diastolic strain rate decrease in parallel, thus reflecting a close relation of systolic and diastolic mechanics of the right ventricle. The intensity of right ventricle diastolic dysfunction is associated with the coronary artery disease complexity.Received 18 October 2016. Accepted 6 February 2017.Financing: The study required no additional funding and sponsorship.Conflict of interest: The authors declare no conflict of interest.Author contributionsConception and study design: E.N. Orekhova, O.A. Osetrova.Data collection and analysis: O.A. Osetrova, O.A. Balyshova.Drafting the article: E.N. Orekhova, O.A. Osetrova.Critical revision of the article: Yu.S. Sinelnikov, E.N. Orekhova.Final approval of the version to be published: Yu.S. Sinelnikov, E.N. Orekhova, O.A. Osetrova, O.A. Balyshova.
Efektivitas Antihiperurisemia Ekstrak Etanol Daun Seledri (EEDS) pada Tikus Induksi Kalium Oksonat
Authors: Rakanita Yasinta , L Hastuti , Tandi Joni , Mulyani Sri 
Published: July 2017

Seledri adalah tanaman yang memiliki kandungan kimia seperti alkaloid, flavonoid, saponin, dan tanin. Penelitian ini bertujuan untuk membuktikan efektivitas ekstrak etanol daun seledri dalam menurunkan kadar asam urat pada tikus putih jantan dan menentukan dosis ekstrak daun seledri yang efektif dalam menurunkan kadar asam urat pada tikus putih jantan. Ekstrak daun seledri dibuat secara maserasi dengan pelarut etanol 96%. Rancangan penelitian yang digunakan adalah Rancangan Acak Kelompok. Data yang diperoleh dianalisis dengan mengunakan uji statistik Analisis Sidik Ragam pada taraf kepercayaan 95% yang mengunakan 30 ekor tikus putih jantan dibagi 6 kelompok perlakuan, tiap perlakuan terdiri dari 5 ekor. Model hewan dibuat hiperurisemia menggunakan penginduksi kalium oksonat dengan dosis 250 mg/kg BB. Kelompok I (normal) diberikan pakan standar, kelompok II (negatif) diberi suspensi Na CMC 0,5%, kelompok III (positif) diberi suspensi allopurinol 5,4 mg/kg BB, kelompok IV, V, dan VI diberi ekstrak etanol daun seledri masing-masing dengan dosis 50 mg/kg BB, 100 mg/kg BB, dan 200 mg/kg BB. Berdasarkan uji lanjut BNJ diperoleh hasil bahwa dosis ekstrak etanol daun seledri yang efektif adalah 50 mg/kg BB.
Determining H0 with the Latest H ii Galaxy Measurements
Authors: Wang Deng , Meng Xin-He 
Published: July 2017

Abstract
We use the latest H ii galaxy measurements to determine the value of H
0 by adopting a combination of model-dependent and model-independent methods. By constraining five cosmological models, we find that the obtained values of H
0 are more consistent with the recent local measurement by Riess et al. at the 1σ confidence level. For the first time, we implement the model-independent Gaussian processes using the H ii galaxy measurements, and confirm the correctness of H
0 values obtained by the model-dependent method at the 1σ confidence level.
Sagittarius
A
*
High-energy X-Ray Flare Properties during NuStar Monitoring of the Galactic Center from 2012 to 2015
Authors: Zhang Shuo , Baganoff Frederick K. , Ponti Gabriele , Neilsen Joseph , Tomsick John A. , Dexter Jason , Clavel Maïca , Markoff Sera , Hailey Charles J. , Mori Kaya , Barrière Nicolas M. , Nowak Michael A. , Boggs Steven E. , Christensen Finn E. , Craig William W. , Grefenstette Brian W. , Harrison Fiona A. , Madsen Kristin K. , Stern Daniel , Zhang William W. 
Published: July 2017

Abstract
Understanding the origin of the flaring activity from the Galactic center supermassive black hole Sagittarius A* is a major scientific goal of the NuSTAR Galactic plane survey campaign. We report on the data obtained between 2012 July and 2015 April, including 27 observations on Sgr A*, with a total exposure of

≃
1

Ms. We found a total of 10 X-ray flares detected in the NuSTAR observation window, with luminosities in the range of

L

3
–
79

keV

∼
(
0.2

–

4.0
)
×

10

35

erg

s

−
1

. With this largest hard X-ray Sgr A* flare data set to date, we studied the flare spectral properties. Seven flares are detected above

5
σ

significance, showing a range of photon indices (Γ ∼ 2.0–2.8) with typical uncertainties of ±0.5 (90% confidence level). We found no significant spectral hardening for brighter flares, as indicated by a smaller sample. The accumulation of all of the flare spectra in 1–79 keV can be well fit with an absorbed power-law model with

Γ
=
2.2
±
0.1

, and does not require the existence of a spectral break. The lack of variation in the X-ray spectral index with luminosity would point to a single mechanism for the flares and is consistent with the synchrotron scenario. Lastly, we present the quiescent-state spectrum of Sgr A*, and derive an upper limit on the quiescent luminosity of Sgr A* above 10 keV to be

L

Xq
,
10
–
79

keV

≤
(
2.9
±
0.2
)
×

10

34

erg s−1.
Simulation d’entretien d’embauche dans un cours de français des affaires : retour sur l’expérience du jeu de rôle enregistré
Authors: Kis Zsuzsa 
Published: July 2017

Le jeu, sous ses formes diverses, permet aux étudiants d’acquérir des compétences professionnelles. L’IAE Lyon accueille des étudiants internationaux en master de gestion préparant un double diplôme. Un stage en entreprise complète leur formation au deuxième semestre. Ces étudiants doivent acquérir dans le cours de « français des affaires » les connaissances et les savoir-faire nécessaires pour postuler dans une entreprise en France en tant que stagiaires. La méthode de la simulation globale, jeu de rôle en entreprise, est un moyen ludique, permettant aux étudiants d’acquérir ces compétences. Cette fiche pédagogique explique la séance de l’entretien d’embauche, composée de deux cours de deux heures. La simulation de l’entretien est complétée par l’enregistrement vidéo de ces entretiens, qui assure une mise à distance et une prise de conscience par les apprenants de leur degré d’assimilation de la situation. Cette fiche s’appuie sur la présentation de l’expérience pédagogique avec une réflexion théorique sur l’importance de l’enregistrement et de son analyse.
Enjeux de l’improvisation théâtrale en cours de langues
Authors: Vazquez De Castro Isabel 
Published: July 2017

Cette fiche pédagogique présente les « Ateliers bilingues d’expression théâtrale » mis en place à l’université de Paris-Est Créteil depuis la rentrée 2013. Ces ateliers bénéficient du soutien IDEA - Initiative d’excellence ANR et ils sont insérés dans la formation du DELCIFE (FLE) et des options transversales proposées pour l’ensemble des étudiants, dont certains suivent un cursus en IUT. Le succès de cette expérience nous permet de préconiser des pratiques semblables en IUT pour l’enseignement apprentissage de langues vivantes. En effet, les ateliers ont permis une aisance suffisante aux étudiants pour pouvoir interagir entre eux autour d’un projet commun de mini-spectacle public final, résultat des tâtonnements produits lors des improvisations successives. Le travail des compétences transversales, de compréhension, expression, médiation linguistique et pragmatique des discours, sans pour autant oublier le travail accompli autour du corps dans l’espace scénique, du geste et de la voix, a permis d’obtenir des améliorations notables -au dire des étudiants- aussi bien en ce qui concerne les résultats académiques que la maîtrise de la langue en situation de communication.
Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology
Authors: Masopust David , Sivula Christine P. , Jameson Stephen C. 
Published: July 2017

Abstract
Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a “dirty” mouse model that better mimics the diverse infectious history that is typical of most humans.
On the limits of Köhler activation theory: how do collision and coalescence affect the activation of aerosols?
Authors: Hoffmann Fabian 
Published: July 2017

Abstract. Activation is necessary to form a cloud droplet from an aerosol, and it is widely accepted that it occurs as soon as a wetted aerosol grows beyond its critical radius. Traditional Köhler theory assumes that this growth is driven by the diffusion of water vapor. However, if the wetted aerosols are large enough, the coalescence of two or more particles is an additional process for accumulating sufficient water for activation. This transition from diffusional to collectional growth marks the limit of traditional Köhler theory and it is studied using a Lagrangian cloud model in which aerosols and cloud droplets are represented by individually simulated particles within large-eddy simulations of shallow cumuli. It is shown that the activation of aerosols larger than 0. 1 µm in dry radius can be affected by collision and coalescence, and its contribution increases with a power-law relation toward larger radii and becomes the only process for the activation of aerosols larger than 0. 4–0. 8 µm depending on aerosol concentration. Due to the natural scarcity of the affected aerosols, the amount of aerosols that are activated by collection is small, with a maximum of 1 in 10 000 activations. The fraction increases as the aerosol concentration increases, but decreases again as the number of aerosols becomes too high and the particles too small to cause collections. Moreover, activation by collection is found to affect primarily aerosols that have been entrained above the cloud base.
Does Rarity Confer Value? Nietzsche on the Exceptional Individual
Authors: Hassan Patrick 
Published: July 2017

Abstract
By drawing upon contemporary debates in the theory of value, in this article I explore the evidence for taking Nietzsche to defend the view that rarity—at least under certain qualified conditions—matters for its own sake. I argue that this evidence is compelling, and that many intuitive objections to the view can be deflected by challenging the axiological assumptions that motivate them. The question concerning the value of rarity has significant evaluative implications concerning Nietzsche's famed critique of morality, and in particular the component of equality. While Nietzsche is traditionally interpreted as rejecting equality in virtue of its “leveling-down” effects upon certain perfectionist values, I claim that if rarity is itself valuable then we are left with a second critique of equality: that it undercuts the value of peculiarity. I explore the extent and significance of this objection in the final section of the article.