bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bytízite, a new Cu-Sb selenide from Příbram, Czech Republic
Authors: Škácha Pavel , Sejkora Jiří , Plášil Jakub 
Published: June 2017

ABSTRACTThe new mineral bytízite was found in the dump of shaft No. 16, one of the mines in the Příbram uranium and base-metal district, central Bohemia, Czech Republic. Bytízite is associated with chaméanite, příbramite, giraudite, berzelianite, umangite, eskebornite, hakite, tetrahedrite, bukovite, crookesite and uraninite in a calcite-dominant gangue. The new mineral occurs as anhedral grains up to 40 µm, growing together in aggregates up to 300 µm across. Bytízite is steel-grey in colour and has a metallic lustre. Mohs hardness is ca. 2–3; the calculated density is 6.324 g cm–3. In reflected light bytízite is grey with a yellowish hue, yellowish and brownish. Bireflectance and pleochroism are weak. Anisotropy is strong with grey to brownish rotation tints. Internal reflections were not observed. The empirical formula, based on electron-microprobe analyses, is (Cu3.00Fe0.01Ag0.01)3.02(Sb0.97As0.06)1.03Se2.94. The ideal formula is Cu3SbSe3, which requires Cu 34.71, Sb 22.16 and Se 43.13, total 100.00 wt.%. Bytízite is orthorhombic, Pnma, a = 7.9594(12), b = 10.5830(14), c = 6.8240(11) Å, with V = 574.82(15) Å3 and Z = 4. The strongest reflections of the calculated powder X-ray diffraction pattern [d, Å (I)(hkl)] are: 3.73(37)(210), 3.27(62)(211), 2.867(40)(022), 2.698(100)(122) and 2.646(37)(040). According to the single-crystal X-ray diffraction data (Robs = 0.0437), bytízite is isostructural with synthetic Cu3SbSe3. The structure of bytízite contains two Cu, one Sb, and two Se sites (the latter is occupied both by Se and S atoms). In the structure of both synthetic Cu3SbSe3 and bytízite, there are groups of three cis-edge-sharing tetrahedra [Cu3Se8], which are interlinked to a 3D framework by SbSe3 groups. Bytízite is named after its type locality, the Bytíz deposit, near the village Bytíz.
Gadolinite-(Nd), a new member of the gadolinite supergroup from Fe-REEdeposits of Bastnäs-type, Sweden
Authors: Škoda Radek , Plášil Jakub , Čopjaková Renata , Novák Milan , Jonsson Erik , Galiová Michaela Vašinová , Holtstam Dan 
Published: June 2017

ABSTRACTA new member of the gadolinite supergroup, gadolinite-(Nd), IMA2016-013, ideally Nd2FeBe2Si2O10, was found in the Malmkärra mine, ~3.5 km WSW of Norberg, south-central Sweden, where it occurs in association with fluorbritholite-(Ce), västmanlandite-(Ce), dollaseite-(Ce), bastnäsite-(Ce) and tremolite. Gadolinite-(Nd) forms anhedral grains up to 150 µm in size, commonly occurring as aggregates of olive green colour. The crystals are transparent with vitreous to adamantine lustre. Gadolinite-(Nd) is brittle with conchoidal fracture, no cleavage or parting was observed. It has a white streak, the Mohs hardness is 6.5–7 and the calculated density is 4.86 g cm–3. Optically, the mineral is weakly pleochroic in shades of olive green, biaxial (–), nα = 1.78(1), nβ(calc.) = 1.80, nγ = 1.81(1) measured in white light, 2V(meas.) = 62(3)°. Electron-microprobe and laser ablation inductively coupled plasma mass spectrometry analysis [in wt.%] provided SiO221.77, Y2O35.49, La2O32.78, Ce2O314.04, Pr2O33.28, Nd2O319.27, Sm2O35.30, Eu2O30.24, Gd2O34.10, Tb2O30.36, Dy2O31.32, Ho2O30.18, Er2O30.38, MgO 0.51, CaO 0.14, MnO 0.10, FeO 10.62, B2O30.10, BeOcalc.8.99, H2Ocalc.0.55 and total 99.52 giving the following empirical formula (based on 2 Si): (Nd0.632Ce0.472Y0.268Sm0.168Gd0.125Pr0.110La0.094Dy0.039Ca0.014Er0.011Tb0.011Eu0.008Ho0.008)∑1.957(Fe0.816Mg0.070Mn0.008)∑0.894(Be1.984B0.016)∑2.000Si2O9.660OH0.337. A weak Raman vibration band at ~3525 cm–1confirms the presence of water in the structure. Gadolinite-(Nd) is monoclinic,P21/c, witha = 4.8216(3) Å,b = 7.6985(4) Å,c = 10.1362(6) Å, β = 90.234(4)°,V = 376.24(6) Å3andZ = 2. The strongest X-ray diffraction lines are [dobsin Å (hkl)Irel]: 4.830 (100) 72, 3.603 (021) 37, 3.191(-112) 52, 3.097 (013) 35, 2.888 (121) 100, 2.607(113) 49, 2.412 (200) 24. Along with the Malmkärra mine, gadolinite-(Nd) was also recorded also at Johannagruvan and Nya Bastnäs. The minerals of the gadolinite subgroup together with fluorbritholite-(Ce) incorporate the highest fraction of medium-to-heavy rare-earth elements among associated rare-earth element minerals in the Malmkärra mine and possibly in all Bastnäs-type deposits.
An original and effective technique to improve exposure in open surgery
Authors: Nohuz E. , Chêne G. 
Published: June 2017

Abstract
Background
Exposure, especially when the organs are enlarged, remains one of the most important issue in open surgery. Considering this constraint appears critical in the progress of the surgical procedure. We highlight our technique which affords optimal exposure and improves manipulation and extraction of enlarged organs.

Results
This original and effective technique is derived from an obstetrical device used to perform an assisted vaginal delivery. It improves exposure, reduces tissue manipulation, and enhances removal of the surgical specimen during hysterectomies and myomectomies. It can be similarly helpful sometimes to grasp and remove (by mini laparotomy) enlarged adnexa during laparoscopic procedures. Moreover, this trick appears particularly suited in case of obese patients.

Conclusion
This new technique procures a real benefit for both the patient and the surgeon in terms of ergonomics and safety.
Psychological treatments for schizophrenia spectrum disorder: What is around the corner?
Authors: Turkington Douglas , Lebert Latoyah 
Published: June 2017

SummaryThe evidence base for cognitive-behavioural therapy (CBT), family therapy, psychoeducation and cognitive remediation as adjuncts to antipsychotic medication in the treatment of schizophrenia is well established. It is, however, clear that the moderate effect size of the best researched of these treatments (CBT) compared with treatment as usual reduces to small when compared with an active psychological treatment. It would seem that many different psychosocial interventions de liver benefit in schizophrenia. We are now at a stage in their development when new treatments are being energetically piloted and combination treatments tested. This article outlines the most promising of these new interventions and attempts to answer the crucial question as to their differential effects on different psychotic presentations.Learning Objectives• Be aware of the most promising new psychosocial treatments for schizophrenia• Learn the key elements of each intervention• Understand which of these approaches might be best suited to particular presentations of schizophrenia spectrum disorder
Diagnosis and treatment: Are psychiatrists choosing wisely?
Authors: Maughan Daniel , James Adrian 
Published: June 2017

SummaryThe UK's Choosing Wisely campaign aims to tackle the pressing issue of overuse in healthcare (i.e. overdiagnosis and overtreatment) through improving awareness and promoting shared decisionmaking. This campaign involves medical societies developing lists of interventions that are of questionable value and so require a genuine discussion between doctors and patients about their use. This article is about the problem of overuse and the launch of the Royal College of Psychiatrists' Choosing Wisely campaign. It provides a critical review of why this might occur and whether Choosing Wisely is likely to be successful.Learning Objectives• Understand the aims of the Choosing Wisely programme• Define overdiagnosis and overtreatment• Develop a critical perspective on potential areas of overuse in your clinical practice
Controversy over exercise therapy for chronic fatigue syndrome: Key lessons for clinicians and academics
Authors: Mitchell Alex J. 
Published: June 2017

SummaryChronic fatigue syndrome (CFS) is syndrome of unremitting fatigue of at least 6 months' duration that causes significant disability. Exercise therapy has a proven track record in medicine and could be effective for some patients with CFS. An updated Cochrane review of eight studies appeared to suggest that exercise helps fatigue symptoms, but with only a small probability of recovery and/or improvement in daily function. Provisional data on acceptability suggest that most patients are willing to participate. However, one key study (PACE), which was well powered and influential in the Cochrane review, has been met with considerable controversy owing to lack of clarity on outcomes. Following release of the PACE study primary data, re-analysis suggested smaller effect sizes than initially reported.
Newer generation antidepressants for young people: Real-life evidence needed
Authors: Hussain Haseena , Dubicka Bernadka , Wilkinson Paul 
Published: June 2017

SummaryMajor depressive disorder in children and adolescents is common and associated with significant morbidity and mortality. This 2012 meta-analysis by Hetrick et al shows statistically significant, but small, improvements in depressive symptom scores and probability of remission with second-generation antidepressants (SGAs) compared with placebo. SGAs lead to a small, but significant, increase in risk of suicidal thoughts/attempts compared with placebo. Patients included in the primary studies had milder depression, less psychiatric comorbidity and less suicidality than those normally seen in clinical practice in the UK's National Health Service. However, primary studies had significant methodological shortcomings. Therefore, caution is needed when trying to generalise results to clinical practice.
Randomized, Noncomparative, Phase II Trial of Early Switch From Docetaxel to Cabazitaxel or Vice Versa, With Integrated Biomarker Analysis, in Men With Chemotherapy-Naïve, Metastatic, Castration-Resistant Prostate Cancer
Authors: Antonarakis Emmanuel S. , Tagawa Scott T. , Galletti Giuseppe , Worroll Daniel , Ballman Karla , Vanhuyse Marie , Sonpavde Guru , North Scott , Albany Costantine , Tsao Che-Kai , Stewart John , Zaher Atef , Szatrowski Ted , Zhou Wei , Gjyrezi Ada , Tasaki Shinsuke , Portella Luigi , Bai Yang , Lannin Timothy B. , Suri Shalu , Gruber Conor N. , Pratt Erica D. , Kirby Brian J. , Eisenberger Mario A. , Nanus David M. , Saad Fred , Giannakakou Paraskevi ,   on behalf of the TAXYNERGY Investigators
Published: June 2017

Purpose The TAXYNERGY trial ( ClinicalTrials.gov identifier: NCT01718353) evaluated clinical benefit from early taxane switch and circulating tumor cell (CTC) biomarkers to interrogate mechanisms of sensitivity or resistance to taxanes in men with chemotherapy-naïve, metastatic, castration-resistant prostate cancer. Patients and Methods Patients were randomly assigned 2:1 to docetaxel or cabazitaxel. Men who did not achieve ≥ 30% prostate-specific antigen (PSA) decline by cycle 4 (C4) switched taxane. The primary clinical endpoint was confirmed ≥ 50% PSA decline versus historical control (TAX327). The primary biomarker endpoint was analysis of post-treatment CTCs to confirm the hypothesis that clinical response was associated with taxane drug-target engagement, evidenced by decreased percent androgen receptor nuclear localization (%ARNL) and increased microtubule bundling. Results Sixty-three patients were randomly assigned to docetaxel (n = 41) or cabazitaxel (n = 22); 44.4% received prior potent androgen receptor–targeted therapy. Overall, 35 patients (55.6%) had confirmed ≥ 50% PSA responses, exceeding the historical control rate of 45.4% (TAX327). Of 61 treated patients, 33 (54.1%) had ≥ 30% PSA declines by C4 and did not switch taxane, 15 patients (24.6%) who did not achieve ≥ 30% PSA declines by C4 switched taxane, and 13 patients (21.3%) discontinued therapy before or at C4. Of patients switching taxane, 46.7% subsequently achieved ≥ 50% PSA decrease. In 26 CTC-evaluable patients, taxane-induced decrease in %ARNL (cycle 1 day 1 v cycle 1 day 8) was associated with a higher rate of ≥ 50% PSA decrease at C4 ( P = .009). Median composite progression-free survival was 9.1 months (95% CI, 4.9 to 11.7 months); median overall survival was not reached at 14 months. Common grade 3 or 4 adverse events included fatigue (13.1%) and febrile neutropenia (11.5%). Conclusion The early taxane switch strategy was associated with improved PSA response rates versus TAX327. Taxane-induced shifts in %ARNL may serve as an early biomarker of clinical benefit in patients treated with taxanes.
Perioperative Surgical Home: Evaluation of a New Protocol Focused on a Multidisciplinary Approach to Manage Children Undergoing Posterior Spinal Fusion Operation
Authors: Kim Eugene , Lee Brian , Cucchiaro Giovanni 
Published: June 2017

BACKGROUND:
The concept of Perioperative Surgical Home has been gaining significant attention in surgical centers. This model is delivering and improving coordinated care in a cost-effective manner to patients undergoing surgical procedures. It starts with the decision for surgical intervention, continues to the intraoperative and postoperative periods, and follows into long-term recovery. Constant re-evaluation of outcomes and modifications of delivery provides a feedback loop for improvement. Children’s Hospital Los Angeles initiated a new protocol in June 2014 to manage children undergoing Posterior Spinal Fusion (PSF) with the goal to improve patient experience and lower the hospital length of stay and cost.

METHODS:
A retrospective chart review identified patients who underwent a PSF for idiopathic scoliosis before and after initiation of a new treatment protocol designed by a team of anesthesiologists, surgeons, nurses, and physical therapists. The new protocol included preoperative teaching of parents and patients, intraoperative anesthetic and surgical management, and immediate to long-term postoperative medical management. In addition to demographics, we examined length of stay, cost of hospitalization, pain scores on discharge, length of patient-controlled analgesia use, time to first solid food intake, and time to ambulation.

RESULTS:
Thirty-six patients were identified preinitiation and postinitiation of the protocol (total n = 72). There was no statistically significant difference in age, sex, use of intrathecal morphine, or estimated blood loss. Patients enrolled in the new protocol had higher American Society of Anesthesiologists classification (P = .003), significantly lower duration of patient-controlled analgesia use, time to first solid food intake, and time to ambulation (P= .001). The pain scores were higher at the time of discharge, although the difference was not statistically significant. Length of stay was significantly shorter in the new protocol group (P = .001), accounting for $292,560 in cost savings for the hospital.

CONCLUSIONS:
These data show that the cooperation of different teams in designing new management guidelines for patients requiring a PSF can significantly decrease the total length of stay and cost of hospitalization without altering quality of care.
Respiratory System Mechanics During Low Versus High Positive End-Expiratory Pressure in Open Abdominal Surgery: A Substudy of PROVHILO Randomized Controlled Trial
Authors: D’Antini Davide , Huhle Robert , Herrmann Jacob , Sulemanji Demet S. , Oto Jun , Raimondo Pasquale , Mirabella Lucia , Hemmes Sabrine N. T. , Schultz Marcus J. , Pelosi Paolo , Kaczka David W. , Vidal Melo Marcos Francisco , Gama de Abreu Marcelo , Cinnella Gilda 
Published: June 2017

BACKGROUND:
In the 2014 PROtective Ventilation using HIgh versus LOw positive end-expiratory pressure (PROVHILO) trial, intraoperative low tidal volume ventilation with high positive end-expiratory pressure (PEEP = 12 cm H2O) and lung recruitment maneuvers did not decrease postoperative pulmonary complications when compared to low PEEP (0–2 cm H2O) approach without recruitment breaths. However, effects of intraoperative PEEP on lung compliance remain poorly understood. We hypothesized that higher PEEP leads to a dominance of intratidal overdistension, whereas lower PEEP results in intratidal recruitment/derecruitment (R/D). To test our hypothesis, we used the volume-dependent elastance index %E
2, a respiratory parameter that allows for noninvasive and radiation-free assessment of dominant overdistension and intratidal R/D. We compared the incidence of intratidal R/D, linear expansion, and overdistension by means of %E
2 in a subset of the PROVHILO cohort.

METHODS:
In 36 patients from 2 participating centers of the PROVHILO trial, we calculated respiratory system elastance (E), resistance (R), and %E
2, a surrogate parameter for intratidal overdistension (%E
2 > 30%) and R/D (%E
2 < 0%). To test the main hypothesis, we compared the incidence of intratidal overdistension (primary end point) and R/D in higher and lower PEEP groups, as measured by %E
2.

RESULTS:

E was increased in the lower compared to higher PEEP group (18.6 [16…22] vs 13.4 [11.0…17.0] cm H2O·L−1; P < .01). %E
2 was reduced in the lower PEEP group compared to higher PEEP (−15.4 [−28.0…6.5] vs 6.2 [−0.8…14.0] %; P < .05). Intratidal R/D was increased in the lower PEEP group (61% vs 22%; P = .037). The incidence of intratidal overdistension did not differ significantly between groups (6%).

CONCLUSIONS:
During mechanical ventilation with protective tidal volumes in patients undergoing open abdominal surgery, lung recruitment followed by PEEP of 12 cm H2O decreased the incidence of intratidal R/D and did not worsen overdistension, when compared to PEEP ≤2 cm H2O.
Stroke Volume Variation–Guided Versus Central Venous Pressure–Guided Low Central Venous Pressure With Milrinone During Living Donor Hepatectomy: A Randomized Double-Blinded Clinical Trial
Authors: Lee Jiwon , Kim Won Ho , Ryu Ho-Geol , Lee Hyung-Chul , Chung Eun-Jin , Yang Seong-Mi , Jung Chul-Woo 
Published: June 2017

BACKGROUND:
We previously demonstrated the usefulness of milrinone for living donor hepatectomy. However, a less-invasive alternative to central venous catheterization and perioperative contributors to good surgical outcomes remain undetermined. The current study evaluated whether the stroke volume variation (SVV)–guided method can substitute central venous catheterization during milrinone-induced profound vasodilation.

METHODS:
We randomly assigned 42 living liver donors to receive either SVV guidance or central venous pressure (CVP) guidance to obtain milrinone-induced low CVP. Target SVV of 9% was used as a substitute for CVP of 5 mm Hg. The surgical field grade evaluated by 2 attending surgeons on a 4-point scale was compared between the CVP- and SVV-guided groups (n = 19, total number of scores = 38 per group) as a primary outcome variable. Multivariable analysis was performed to identify independent factors associated with the best surgical field as a post hoc analysis.

RESULTS:
Surgical field grades, which were either 1 or 2, were not found to be different between the 2 groups via Mann-Whitney U test (P = .358). There was a very weak correlation between SVV and CVP during profound vasodilation such as CVP ≤ 5 mm Hg (R = −0.06; 95% confidence interval, −0.09 to −0.04; P < .001). Additional post hoc analysis suggested that younger age, lower baseline CVP, and longer duration of milrinone infusion might be helpful in providing the best surgical field.

CONCLUSIONS:
Milrinone-induced vasodilation resulted in favorable surgical environment regardless of guidance methods of low CVP during living donor hepatectomy. However, SVV was not a useful indicator of low CVP because of very weak correlation between SVV and CVP during profound vasodilation. In addition, factors contributing to the best surgical field such as donor age, proactive fasting, and proper dosing of milrinone need to be investigated further, ideally through prospective studies.
Deficiency of PHB complex impairs respiratory supercomplex formation and activates mitochondrial flashes
Authors: Jian Chongshu , Xu Fengli , Hou Tingting , Sun Tao , Li Jinghang , Cheng Heping , Wang Xianhua 
Published: June 2017

ABSTRACT
Prohibitins (PHBs; prohibitin 1, PHB1 or PHB, and prohibitin 2, PHB2) are evolutionarily conserved and ubiquitously expressed mitochondrial proteins. PHBs form multimeric ring complexes acting as scaffolds in the inner mitochondrial membrane. Mitochondrial flashes (mitoflashes) are newly discovered mitochondrial signaling events that reflect electrical and chemical excitations of the organelle. Here, we investigate the possible roles of PHBs in the regulation of mitoflash signaling. Downregulation of PHBs increases mitoflash frequency by up to 5.4-fold due to elevated basal reactive oxygen species (ROS) production in the mitochondria. Mechanistically, PHB deficiency impairs the formation of mitochondrial respiratory supercomplexes (RSCs) without altering the abundance of individual respiratory complex subunits. These impairments induced by PHB deficiency are effectively rescued by co-expression of PHB1 and PHB2, indicating that the multimeric PHB complex acts as the functional unit. Furthermore, downregulating other RSC assembly factors, including SCAFI (also known as COX7A2L), RCF1a (HIGD1A), RCF1b (HIGD2A), UQCC3 and SLP2 (STOML2), all activate mitoflashes through elevating mitochondrial ROS production. Our findings identify the PHB complex as a new regulator of RSC formation and mitoflash signaling, and delineate a general relationship among RSC formation, basal ROS production and mitoflash biogenesis.
Creating Online Quizzes with Multiple Attempts with Microsoft Excel and Word
Authors: Kim Dong-gook “DK” , Kim Jihye 
Published: June 2017

Problem solving plays an important role in students’ learning, especially in quantitative topics, such as mathematics, statistics, operations research, and management sciences. Learning management systems (LMS) and online homework management systems can assist students’ learning by offering quizzes and tests allowing multiple attempts with immediate feedback. In this paper, using the software readily available to most institutions (Microsoft Word and Microsoft Excel), we explain how to create quizzes in an LMS, such as Desire2Learn, that allow students multiple attempts. Although most systems offer a way to create questions algorithmically, the functions available for creating those questions are limited. As a result, they are often unsuitable for complex quantitative topics. The method shown in this paper overcomes the limitation of algorithmic questions in an LMS. The Excel dataset is available at https://doi.org/10.1287/ited.2017.0170
Sunny, Rainy, and Cloudy with a Chance of Mobile Promotion Effectiveness
Authors: Li Chenxi , Luo Xueming , Zhang Cheng , Wang Xiaoyi 
Published: June 2017

Although firms are leveraging weather conditions in promotions, they struggle to quantify the impact. This study exploits field experiment data on weather-based mobile promotions with over six million users. Results find that sunny and rainy weather have first-order main effects. Purchase responses to promotions are higher and faster in sunny weather relative to cloudy weather, whereas purchase responses to promotions are lower and slower in rainy weather. These findings are robust across different measures of weather changes with both backward-looking historical weather and forward-looking forecasts, as well as deviations from normal weather. Also, sunny and rainy weather have second-order interactive effects with ad copies of mobile promotions. Compared with the neutral ad copy, the prevention frame ad copy hurts the initial promotion boost induced by sunshine, but improves the initial promotion drop induced by rainfall. For marketers, these findings imply new opportunities in customer data analytics for more effective weather-based mobile targeting. Data and the online appendix are available at https://doi.org/10.1287/mksc.2017.1044 .