bluuebunny/crossref_metadata_2025_split huggingface dataset:
The sociological dimension of concrete interiors during the 1960s
Authors: Campens Angelique 
Published: May 2017

AbstractAlmost all architects today have abandoned making prescriptions for how people should live. They have learned from the mistakes of Modernism, when architects sought to construct the ideal home for the family. The now nearly universal judgment is that they inhibited the very thing they promised because their ideals failed to understand that living is a continual process of growth and adaptation. Nevertheless, many modernist homes still exist, and many are strikingly beautiful, with unique aesthetic and sculptural qualities. Of particular note are homes built in the 1960s, when a series of architects used the booming trade in concrete to create buildings of the most imaginary shapes and forms. But how can the modern family make their everyday lives in a space that is itself a work of art? How are inhabitants making homes in these complex, concrete structures? How did the family unit grow and evolve in them? To answer the questions, the most proscriptive designs are the most interesting to study. They take us beyond formal analyses and into the praxis of art, where we must rely on sociology and psychology as much as aesthetics. This article will engage these broader questions through a specific focus on homes designed by Juliaan Lampens. The research draws from archival work, literature study, on-site visits and interviews. Lampens is significant not only for the boldness of his forms but for his insistence on limiting walls and creating extremes of openness within the home. This article argues against a pure ideological critique of Lampens’ homes and focus instead on an understanding of how the homes were actually inhabited. In this way this article seeks to restore to modernism its complexity as a lived reality rather than criticize it in terms of its own formalism. These are considered alongside other architects, contemporary to Lampens, who shared similar ideas about living and building. Together these dwellings constitute a constellation that highlights the international scope and variation of Brutalism and, furthermore, brings to light the often overlooked unique sculptural qualities, forms and characteristics that emerged within Brutalist architecture. The essay focuses on two homes: the Vandenhaute home, built for a family of six, and the Vanwassenhove home that had a solo inhabitant. Lampens proposed strict regulations for those in his homes. The essay traces how Lampens developed this position to the extreme, and, in so doing, really did change how people lived. At the same time, this paper insists that architecture is part of a social world, and we need to evaluate both its successes and failures in order to better understand the potentials for future utopian design. This article is published as part of a collection on interiorities.
Cap-binding protein 4EHP effects translation silencing by microRNAs
Authors: Chapat Clément , Jafarnejad Seyed Mehdi , Matta-Camacho Edna , Hesketh Geoffrey G. , Gelbart Idit A. , Attig Jan , Gkogkas Christos G. , Alain Tommy , Stern-Ginossar Noam , Fabian Marc R. , Gingras Anne-Claude , Duchaine Thomas F. , Sonenberg Nahum 
Published: May 2017

Significance
miRNAs are important components of gene regulatory networks and affect all aspects of cell biology by controlling the stability and translation efficiency of their target mRNAs. Here, we identified the mRNA cap-binding eIF4E-related protein 4EHP as an effector of miRNA-mediated translation repression. Through screening for protein interactions in cells via the BioID method, we identified 4EHP as a component of the CCR4–NOT/DDX6/4E-T axis. Direct interaction between 4E-T and 4EHP increases the latter’s cap-binding affinity, suggesting that this interaction potentiates its competition with the eIF4F complex for binding to the mRNA 5′ cap. Our findings suggest that 4EHP facilitates the formation of a closed-loop structure between the 3′ UTR of the mRNA and its 5′ cap, which causes repression of mRNA translation.
Single-crystal
I

h

ice surfaces unveil connection between macroscopic and molecular structure
Authors: Brumberg Alexandra , Hammonds Kevin , Baker Ian , Backus Ellen H. G. , Bisson Patrick J. , Bonn Mischa , Daghlian Charles P. , Mezger Markus , Shultz Mary Jane 
Published: May 2017

Significance
Ice surface molecular structures determine reactions and interactions on ice. Observation of macroscopic (etch pit) and microscopic (electron backscatter diffraction orientation density function) images definitively shows the molecular-level termination and the layer structure. Identification of the molecular-level structure enables a statistical model that accounts for observation of contrasting growth from the vapor and growth from the liquid. At the solid–vapor interface, the surface is dominated by primary prism and basal faces. In contrast, the secondary prism face dominates at the solid–liquid interface. A statistical model suggests a basis for this contrast: growth at the liquid–solid interface is enthalpically driven, whereas poor thermal transport in the vapor suppresses growth of the secondary prism face.
Bilateral comparison of 10 pF and 100 pF standards (ongoing BIPM key comparisons BIPM.EM-K14.a and 14.b) between the NIS (Egypt) and the BIPM
Authors: Gournay Pierre , Helmy M , Raouf A , Hamed Heba A M , Gad A Eliwa 
Published: May 2017

This report presents the results of a bilateral comparison of 10 pF and 100 pF capacitance standards between the NIS (Egypt) and the BIPM carried out in 2016. The comparison at 10 pF forms part of the ongoing BIPM key comparison BIPM.EM-K14.a and that at 100 pF of the ongoing BIPM key comparison BIPM.EM-K14.b. The BIPM is the pilot laboratory for both of these comparisons.
Two 10 pF and 100 pF travelling standards belonging to the BIPM were used in this comparison carried out with an 'A-B-A' pattern of measurements. The standards were measured first at the BIPM for a period of about one month, then for a similar period at the NIS, and finally again at the BIPM. The measurand was the two terminal-pair capacitance at a frequency of either 1000 Hz or 1592 Hz, for a measuring rms voltage of 15 V at 10 pF and 10 V at 100 pF.
One of the 10 pF travelling standards had to be eliminated from the comparison due to a bistable behaviour, possibly due to transportation.
The results from the NIS and the BIPM at both 1000 Hz and 1592 Hz were found to be in good agreement, with a difference smaller than the relative expanded uncertainty (95 % confidence, k = 2) of about 0.72 × 10-6 at 10 pF and about 0.65 × 10-6 at 100 pF.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Bilateral comparison of 100 pF standards (ongoing BIPM key comparison BIPM.EM-K14.b) between the NSAI-NML (Ireland) and the BIPM
Authors: Gournay Pierre , Power Oliver 
Published: May 2017

This report presents the results of a bilateral comparison of capacitance at 100 pF between the NSAI-NML (Ireland) and the BIPM carried out in 2016. This comparison forms part of the ongoing BIPM key comparison BIPM.EM-K14.b in which the BIPM is the pilot laboratory.
Two 100 pF travelling standards belonging to the BIPM were used in this comparison carried out with an 'A-B-A' pattern of measurements. The standards were measured first at the BIPM for a period of about one month, then for a similar period at the NSAI-NML, and finally again at the BIPM. The measurand was the two terminal-pair capacitance at a frequency of 1000 Hz, for a measuring rms voltage of 15 V.
The results from the NSAI-NML and the BIPM were found to be in relatively good agreement, with a difference smaller than the relative expanded uncertainty (95 % confidence, k = 2) of 0.85 × 10-6.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Bilateral comparison of 10 pF and 100 pF standards (ongoing BIPM key comparisons BIPM.EM-K14.a and 14.b) between the NMISA (South Africa) and the BIPM
Authors: Gournay Pierre , Khoza Michael 
Published: May 2017

This report presents the results of a bilateral comparison of 10 pF and 100 pF capacitance standards between the NMISA (South Africa) and the BIPM carried out in 2016. The comparison at 10 pF forms part of the ongoing BIPM key comparison BIPM.EM-K14.a and that at 100 pF of the ongoing BIPM key comparison BIPM.EM-K14.b. The BIPM is the pilot laboratory for both of these comparisons.
Two 10 pF and 100 pF travelling standards belonging to the BIPM were used in this comparison carried out with an 'A-B-A' pattern of measurements. The standards were measured first at the BIPM for a period of about one month, then for a similar period at the NMISA, and finally again at the BIPM. The measurand was the two terminal-pair capacitance at a frequency of either 1000 Hz or 1592 Hz, for a measuring rms voltage of 15 V at 10 pF and 10 V at 100 pF.
One of the 10 pF travelling standards had to be eliminated from the comparison due to a bistable behaviour, possibly due to transportation.
The results from the NMISA and the BIPM at both 1000 Hz and 1592 Hz were found to be in good agreement, with a difference smaller than the relative expanded uncertainty (95 % confidence, k = 2) of maximum value 0.33 × 10-6 at 10 pF and 0.24 × 10-6 at 100 pF (and 1000 Hz in both cases).

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Recent computational developments on CLIP-seq data analysis and microRNA targeting implications
Authors: Bottini Silvia , Pratella David , Grandjean Valerie , Repetto Emanuela , Trabucchi Michele 
Published: May 2017

AbstractCross-Linking Immunoprecipitation associated to high-throughput sequencing (CLIP-seq) is a technique used to identify RNA directly bound to RNA-binding proteins across the entire transcriptome in cell or tissue samples. Recent technological and computational advances permit the analysis of many CLIP-seq samples simultaneously, allowing us to reveal the comprehensive network of RNA–protein interaction and to integrate it to other genome-wide analyses. Therefore, the design and quality management of the CLIP-seq analyses are of critical importance to extract clean and biological meaningful information from CLIP-seq experiments. The application of CLIP-seq technique to Argonaute 2 (Ago2) protein, the main component of the microRNA (miRNA)-induced silencing complex, reveals the direct binding sites of miRNAs, thus providing insightful information about the role played by miRNA(s). In this review, we summarize and discuss the most recent computational methods for CLIP-seq analysis, and discuss their impact on Ago2/miRNA-binding site identification and prediction with a regard toward human pathologies.
POSSUM: a bioinformatics toolkit for generating numerical sequence feature descriptors based on PSSM profiles
Authors: Wang Jiawei , Yang Bingjiao , Revote Jerico , Leier André , Marquez-Lago Tatiana T , Webb Geoffrey , Song Jiangning , Chou Kuo-Chen , Lithgow Trevor 
Published: May 2017

Abstract

Summary
Evolutionary information in the form of a Position-Specific Scoring Matrix (PSSM) is a widely used and highly informative representation of protein sequences. Accordingly, PSSM-based feature descriptors have been successfully applied to improve the performance of various predictors of protein attributes. Even though a number of algorithms have been proposed in previous studies, there is currently no universal web server or toolkit available for generating this wide variety of descriptors. Here, we present POSSUM (Position-Specific Scoring matrix-based feature generator for machine learning), a versatile toolkit with an online web server that can generate 21 types of PSSM-based feature descriptors, thereby addressing a crucial need for bioinformaticians and computational biologists. We envisage that this comprehensive toolkit will be widely used as a powerful tool to facilitate feature extraction, selection, and benchmarking of machine learning-based models, thereby contributing to a more effective analysis and modeling pipeline for bioinformatics research.

Availability and implementation
http://possum.erc.monash.edu/.

Supplementary information
Supplementary data are available at Bioinformatics online.
PROXiMATE: a database of mutant protein–protein complex thermodynamics and kinetics
Authors: Jemimah Sherlyn , Yugandhar K , Michael Gromiha M 
Published: May 2017

Abstract

Summary
We have developed PROXiMATE, a database of thermodynamic data for more than 6000 missense mutations in 174 heterodimeric protein–protein complexes, supplemented with interaction network data from STRING database, solvent accessibility, sequence, structural and functional information, experimental conditions and literature information. Additional features include complex structure visualization, search and display options, download options and a provision for users to upload their data.

Availability and implementation
The database is freely available at http://www.iitm.ac.in/bioinfo/PROXiMATE/. The website is implemented in Python, and supports recent versions of major browsers such as IE10, Firefox, Chrome and Opera.

Supplementary information
Supplementary data are available at Bioinformatics online.
Mining 100 million notes to find homelessness and adverse childhood experiences: 2 case studies of rare and severe social determinants of health in electronic health records
Authors: Bejan Cosmin A , Angiolillo John , Conway Douglas , Nash Robertson , Shirey-Rice Jana K , Lipworth Loren , Cronin Robert M , Pulley Jill , Kripalani Sunil , Barkin Shari , Johnson Kevin B , Denny Joshua C 
Published: May 2017

AbstractObjectiveUnderstanding how to identify the social determinants of health from electronic health records (EHRs) could provide important insights to understand health or disease outcomes. We developed a methodology to capture 2 rare and severe social determinants of health, homelessness and adverse childhood experiences (ACEs), from a large EHR repository.Materials and MethodsWe first constructed lexicons to capture homelessness and ACE phenotypic profiles. We employed word2vec and lexical associations to mine homelessness-related words. Next, using relevance feedback, we refined the 2 profiles with iterative searches over 100 million notes from the Vanderbilt EHR. Seven assessors manually reviewed the top-ranked results of 2544 patient visits relevant for homelessness and 1000 patients relevant for ACE.Resultsword2vec yielded better performance (area under the precision-recall curve [AUPRC] of 0.94) than lexical associations (AUPRC = 0.83) for extracting homelessness-related words. A comparative study of searches for the 2 phenotypes revealed a higher performance achieved for homelessness (AUPRC = 0.95) than ACE (AUPRC = 0.79). A temporal analysis of the homeless population showed that the majority experienced chronic homelessness. Most ACE patients suffered sexual (70%) and/or physical (50.6%) abuse, with the top-ranked abuser keywords being “father” (21.8%) and “mother” (15.4%). Top prevalent associated conditions for homeless patients were lack of housing (62.8%) and tobacco use disorder (61.5%), while for ACE patients it was mental disorders (36.6%–47.6%).ConclusionWe provide an efficient solution for mining homelessness and ACE information from EHRs, which can facilitate large clinical and genetic studies of these social determinants of health.
Basilar Artery Ectasia Causing Trigeminal Neuralgia: An Evolved Technique of Transpositional Suture-Pexy
Authors: Singh Harminder , da Silva Harley Brito , Zeinalizadeh Mehdi , Elarjani Turki , Straus David , Sekhar Laligam N 
Published: May 2017

Abstract

BACKGROUND
Microvascular decompression for patients with trigeminal neuralgia (TGN) is widely accepted as one of the modalities of treatment. The standard approach has been retrosigmoid suboccipital craniotomy with placement of a Teflon pledget to cushion the trigeminal nerve from the offending artery, or cauterize and divide the offending vein(s). However, in cases of severe compression caused by a large artery, the standard decompression technique may not be effective.

OBJECTIVE
To describe a unique technique of vasculopexy of the ectatic basilar artery to the tentorium in a patient with TGN attributed to a severely ectatic and tortuous basilar artery. A case series of patients who underwent this technique of vasculopexy for arterial compression is presented.

METHODS
The patient underwent a subtemporal transtentorial approach and the basilar artery was mobilized away from the trigeminal nerve. A suture was then passed through the wall of the basilar artery (tunica media) and secured to the tentorial edge, to keep the artery away from the nerve.

RESULTS
The neuralgia was promptly relieved after the operation, with no complications. A postoperative magnetic resonance imaging scan showed the basilar artery to be away from the trigeminal root. In a series of 7 patients who underwent this technique of vasculopexy, no arterial complications were noted at short- or long-term follow-up.

CONCLUSION
Repositioning and vasculopexy of an ectatic basilar artery for the treatment of TGN is safe and effective. This technique can also be used for other neuropathies that result from direct arterial compression.
Cannabis for the Treatment of Chronic Pain in the Era of an Opioid Epidemic: A Symposium-Based Review of Sociomedical Science
Authors: Maher Dermot P , Carr Daniel B , Hill Kevin , McGeeney Brian , Weed Valerie , Jackson William C , DiBenedetto David J , Moriarty Edward M , Kulich Ronald J 
Published: May 2017

Abstract

Objective
This manuscript reviews medical literature published pertaining to the management of chronic pain with medical marijuana therapy (MMJ), with an emphasis on the social, medical, and legal aspects of therapy.

Design
Narrative review of peer-reviewed literature.

Methods
The 3rd Symposium on Controlled Substances and Their Alternatives for the Treatment of Pain was held in Boston on February 27, 2016, with a focus on MMJ for the treatment of chronic pain. Invited speakers had diverse backgrounds, including pain management, addiction psychiatry, neurology, and legal authorities. The purpose of this conference and this subsequent narrative review is to provide a medical, legal, and logistical framework for physicians and other health care providers to refer to when considering the initiation of medical marijuana therapy.

Results
The invited speakers each covered a unique aspect of MMJ therapy for the treatment of chronic pain. These presentations highlighted the current data for and against the use of MMJ as a pain therapy. Optimal patient selection and screening, in addition to policy developments, were discussed.

Conclusions
Increasing interest in MMJ for chronic pain underscores a need for primary care and pain physicians to better understand the indications and evidence for its use free from cultural bias. Given a lack of full conclusive clinical utility, continued research is needed to better understand how to best utilize MMJ therapy for the treatment of chronic pain. Policy initiatives, such as enumerated indications, should follow medical science in order to prevent another abused substance epidemic.
Pediatric Resident Academic Projects While on Global Health Electives: Ten Years of Experience at the University of Minnesota
Authors: Pitt Michael B. , Slusher Tina M. , Howard Cynthia R. , Cole Valerie B. , Gladding Sophia P. 
Published: May 2017

Purpose
Many residency programs require residents to complete an academic project as part of a global health (GH) elective. However, there has been little description of the range of projects residents have pursued during GH electives or the extent to which these projects are consistent with proposed best practices.

Method
The authors conducted a document review of 67 written summaries or copies of presentations of academic projects (hereafter, summaries) completed by pediatric and medicine–pediatric residents at the University of Minnesota while on GH electives from 2005 to 2015. Two authors independently coded each summary for the type of project completed; when the project idea was generated; explicit mention of a mentor from the home institution, host institution, or both; whether a needs assessment was conducted; and whether there were plans for sustainability.

Results
Most of the 67 projects were categorized into one of three project types: quality/process improvement (28 [42%]), education (18 [27%]), or clinical research (14 [21%]). Most summaries explicitly mentioned a mentor (45 [67%]), reported conducting a needs assessment (38 [57%]), and indicated sustainability plans (45 [67%]). Of the 42 summaries that indicated the timing of idea generation, 30 (71%) indicated the idea was developed after arriving at the host site.

Conclusions
Residents undertook a wide range of academic projects during GH electives, most commonly quality/process improvement and education projects. The projects were largely aligned with best practices, with most summaries indicating the resident worked with a mentor, conducted a needs assessment, and made plans for sustainability.