bluuebunny/crossref_metadata_2025_split huggingface dataset:
Greater sensitivity to multiple sclerosis disability worsening and progression events using a roving versus a fixed reference value in a prospective cohort study
Authors: Kappos Ludwig , Butzkueven Helmut , Wiendl Heinz , Spelman Timothy , Pellegrini Fabio , Chen Yi , Dong Qunming , Koendgen Harold , Belachew Shibeshih , Trojano Maria ,   On Behalf of the Tysabri® Observational Program (TOP) Investigators
Published: May 2017

Background: Confirmed Expanded Disability Status Scale (EDSS) progression occurring after a fixed-study entry baseline is a common measure of disability increase in relapsing-remitting multiple sclerosis (RRMS) studies but may not detect all disability progression events, especially those unrelated to overt relapses. Objective: To evaluate possible measures of disability progression unrelated to relapse using EDSS data over ≈5.5 years from the Tysabri® Observational Program (TOP). Methods: TOP is an ongoing, prospective, open-label study in RRMS patients receiving intravenous 300 mg natalizumab every 4 weeks. Measures of increasing disability were assessed using as a reference either study baseline score or a “roving” system that resets the reference score after ⩾24- or ⩾48-week confirmation of a new score. Results: This analysis included 5562 patients. Approximately 70% more EDSS progression events unrelated to relapse and 50% more EDSS worsening events overall were detected with a roving reference score (cumulative probability: 17.6% and 29.7%, respectively) than with a fixed reference baseline score (cumulative probability: 10.1% and 20.3%, respectively). Conclusion: In this long-term observational RRMS dataset, a roving EDSS reference value was more efficient than a study baseline EDSS reference in detecting progression/worsening events unrelated to relapses and thus the transition to secondary progressive disease.
The Use of Computerized Decision Support Systems in Preventive Cardiology—Principal Results from the National Precard® Survey in Denmark
Authors: Bonnevie Lise , Thomsen Troels , Jørgensen Torben 
Published: May 2017

Background The PRECARD® program has been used for electronic cardiovascular disease (CVD) risk assessment and management in Denmark since 1999. The use of and attitudes toward the program are reported. Design and Methods Using an Internet and postal survey to all Danish general practitioners, a total of 592 Danish general practitioners participated in the Internet part of the survey (response rate 19%) and 291 in the postal survey (response rate 73%). Results in all, 21.5% of the GPs use PRECARD®, whereas 10% are ex-users. The program is used on average once a week and 64% of the users report that PRECARD® prolongs the consultation somewhat or a lot Both users and ex-users perceive the program to have a favourable effect on the patients, and as an improvement to the dialogue between GP and patient Reasons for no longer using the program are varied, such as technical problems and lack of routine with the program. Conclusions Our results indicate that an electronic risk management tool like PRECARD®, is perceived as a quality improvement in preventive cardiology in primary care. However the use of the program is not optimal and it may prolong the consultation. Eur J Cardiovasc Prev Rehabil 12:52-55 © 2005 The European Society of Cardiology
The SaM (Screening and Monitoring) Approach to Cardiovascular Risk-Reduction in Primary Care—Cyclic Monitoring and Individual Treatment of Patients at Cardiovascular Risk using the Electronic Medical Record
Authors: Rabinowitz Israel , Tamir Ada 
Published: May 2017

Background Cardiovascular disease (CVD) prevention suffers from a major gap between clinical evidence (information) and clinical practice (implementation). Insufficient control risk factor levels and under-utilization of aspirin, statins, angiotensin-converting enzyme (ACE) inhibitors and beta-blockers are well-known examples. Methods The SaM (Screening and Monitoring) approach was devised by a family physician in order to facilitate closure of this gap. It does so by providing solutions to problems in the fields of information and implementation. A simple manipulation of the electronic medical record used in the practice serves to facilitate cyclic monitoring of patients with cardiovascular risk factors. Technological and human resources available in the primary care setting are used. The approach is described in the first part of the article. The second part presents results obtained by employing the approach on one family physician's patient population. Results The final results demonstrate a marked improvement over time in risk factor levels and use of medications in accordance with Indications. The values achieved are superior to those reported in the literature. Blood pressure in hypertensive patients 134/75 mmHg; haemoglobin A1c 7.27%; low-density lipoprotein-cholesterol in patients with CVD or diabetes, 97mg/dl; patients with CVD receiving anti-thrombotic medication, 94%; dyslipidaemic patients with CVD or diabetes receiving lipid-lowering drugs, 90%; post myocardial infarction patients receiving beta-blockers, 76%; hypertensive diabetics or patients with chronic heart failure (CHF) receiving ACE-inhibitors/angiotensin receptor blockers, 86%. Conclusions In this one-practice pilot-study, the SaM approach was employed with marked improvement in risk factor levels and use of appropriate medications. This may translate into reductions in morbidity and mortality in a larger population. Eur J Cardiovasc Prev Rehabil 12:56-62 © 2005 The European Society of Cardiology
Socio-Economic Status in Relation to Risk Factors Associated with Cardiovascular Disease, in Healthy Individuals from the ATTICA Study
Authors: Panagiotakos Demosthenes B. , Pitsavos Christos , Manios Yannis , Polychronopoulos Evangelos , Chrysohoou Christina A. , Stefanadis Christodoulos 
Published: May 2017

BackgroundSocial status has been related with the prevalence and incidence of cardiovascular disease. The aim of this study is to investigate the relationships between socio-economic status (SES) and clinical and biochemical factors related to coronary heart disease, in a sample of cardiovascular disease-free men and women.DesignCross-sectional survey.MethodsDuring 2001-2002, 1514 men (20-87 years old) and 1528 women (20-89 years old) from the Attica region (Greece) were randomly enrolled into the study. Trends in established and emerging cardiovascular risk factors were examined across the participants' socio-economic status. A special index was developed (years of school by annual income) and three socio-economic classes were created.ResultsAn inverse relationship was found regarding all lipids and glucose levels across the tertiles of the SES index. An inverse association was observed between body mass index, waist-to-hip ratio and SES in men, but not in women. Furthermore, compared to the lowest tertile, individuals who were classified in the highest SES tertile had lower levels of C-reactive protein, fibrinogen, homocysteine, tumour necrosis factor-α, interleukin-6 levels and white blood cell counts, even after adjusting for various potential confounders. Finally, a considerable proportion of men and women reported lack of health knowledge and education.ConclusionsAn inverse association between SES and factors related to cardiovascular risk exists, but the causal pathway itself requires more detailed explanation before the social status can have explanatory power.
A Comparative Biomechanical Analysis of 2 Double-Row, Distal Triceps Tendon Repairs
Authors: Dorweiler Matthew A. , Van Dyke Rufus O. , Siska Robert C. , Boin Michael A. , DiPaola Mathew J. 
Published: May 2017

Background: Triceps tendon ruptures are rare orthopaedic injuries that almost always require surgical repair. This study tests the biomechanical properties of an original anchorless double-row triceps repair against a previously reported knotless double-row repair. Hypothesis: The anchorless double-row triceps repair technique will yield similar biomechanical properties when compared with the knotless double-row repair technique. Study Design: Controlled laboratory study. Methods: Eighteen cadaver arms were randomized into 2 groups. One group received the anchorless repair and the other received the knotless anchor repair. A materials testing system (MTS) machine was used to cycle the repaired arms from 0° to 90° with a 2.5-pound weight for 1500 cycles at 0.25 Hz. Real-time displacement of the tendon was measured during cycling using a probe. Load to failure was performed after completion of cyclic loading. Results: The mean displacement with the anchorless technique was 0.77 mm (SD, 0.25 mm) at 0° (full elbow extension) and 0.76 mm (SD, 0.38 mm) at 90° (elbow flexion). The mean displacement with the anchored technique was 0.83 mm (SD, 0.57 mm) at 0° and 1.01 mm (SD, 0.62 mm) at 90°. There was no statistically significant difference for tendon displacement at 0º ( P = .75) or 90º ( P = .31). The mean load to failure with the anchorless technique was 618.9 N (SD, 185.6 N), while it was 560.5 N (SD, 154.1 N) with the anchored technique, again with no statistically significant difference ( P = .28). Conclusion: Our anchorless double-row triceps repair technique yields comparable biomechanical properties to previously described double-row triceps tendon repair techniques, with the added benefit of avoiding the cost of suture anchors. Clinical Relevance: This anchorless double-row triceps tendon repair can be considered as an acceptable alternative to a knotless anchor repair for triceps tendon ruptures.
(Un)beliveable wages? An analysis of minimum wage policies in Europe from a living wage perspective
Authors: Fabo Brian , Belli Sharon Sarah 
Published: May 2017

AbstractMinimum wage is one of the most debated issues in the labour policy area. Often perceived as a trade-off between employment and equality in earnings, the debate on minimum wage is highly polarized. With regard to the undergoing discussions on the Social Pillar of the European integration, we aim to extend the debate to include the aspect of minimum living standards, by empirically showing the gap between minimum wages and the minimum living wages in the peripheral countries of the European Union.JEL Classification:J39
The progress of Chinese burn medicine from the Third Military Medical University—in memory of its pioneer, Professor Li Ao
Authors: Li Haisheng , Wang Fengjun , Zhou Junyi , Peng Yizhi , Zhang Jiaping , Peng Xi , Luo Qizhi , Yuan Zhiqiang , Yan Hong , Peng Daizhi , He Weifeng , Liang Guangping , Huang Yuesheng , Wu Jun , Luo Gaoxing 
Published: May 2017

Abstract
Professor Li Ao was one of the founders of Chinese burn medicine and one of the most renowned doctors and researchers of burns in China. He established one of the Chinese earliest special departments for burns at Third Military Medical University (TMMU) in 1958. To memorialize Professor Li Ao on his 100th birthday in 2017 and introduce our extensive experience, it is our honor to briefly review the development and achievement of the Chinese burn medicine from TMMU. The epidemiology and outcomes of admitted burn patients since 1958 were reviewed. Furthermore, main achievements of basic and clinical research for the past roughly 60 years were presented. These achievements mainly included the Chinese Rule of Nine, fluid resuscitation protocol, experience in inhalation injury, wound treatment strategies, prevention and treatment of burn infections, nutrition therapy, organ support therapies, and rehabilitation. The progress shaped and enriched modern Chinese burn medicine and promoted the development of world burn medicine.
Iterative reconstruction in single-source dual-energy CT angiography: feasibility of low and ultra-low volume contrast medium protocols
Authors: Hou Ping , Feng Xiangnan , Liu Jie , Zhou Yue , Jiang Yaojun , Jiang Xiaochen , Gao Jianbo 
Published: May 2017

Objective:
To evaluate the feasibility of using contrast medium (CM) of low and ultra-low volumes and injection rates in aortic CT angiography (CTA) through the joint application of single-source dual-energy CT (ssDECT) and adaptive statistical iterative reconstruction (ASIR).

Methods:
120 patients with known or suspected aortic dissection underwent aortic CTA and were equally divided into 3 groups. Conventional 120-kVp scan with a CM volume of 70 ml and an injection rate of 5 ml s−1 was performed on Group A. Groups B and C underwent ssDECT scan with CM volumes of 0.6 and 0.4 ml kg−1, respectively. 40% and 50% ASIR algorithms were applied for Groups B and C, respectively. A five-point grading scheme was utilized to subjectively evaluate the image quality, and the CT value and contrast-to-noise ratio were recorded as objective measures. The radiation dose was also evaluated.

Results:
Groups B and C had equivalent subjective scores and CT values as Group A, whereas they had higher or equivalent contrast-to-noise ratios. Group B had 40.1% and 30% reductions on CM volume and injection rate, respectively, than Group A. Group C further resulted in 19.2% and 22% lesser CM volume and injection rate than Group B. The average effective radiation doses for the study groups were 22.5–24.5% lower than the control group.

Conclusion:
With the aid of ASIR and ssDECT for aortic CTA, it is feasible to adopt low and ultra-low CM volumes and injection rates while obtaining good quality images.

Advances in knowledge:
Low and ultra-low CM volumes and injection rates are feasible in CTA through the joint application of ssDECT and ASIR.
Optimal Merchandise Testing with Limited Inventory
Authors: Chen Li , Mersereau Adam J. , Wang Zhe (Frank) 
Published: May 2017

We consider the allocation of inventory to stores in a “merchandise test,” whereby a fashion retailer deploys a new product to stores in limited quantities in order to learn about demand prior to the main selling season. Our problem formulation includes practical considerations like fixed costs and multiperiod inventory considerations but is challenging to analyze directly. Instead, we take a bounding approach that isolates the novel aspect of our problem: the impact of test inventory allocation on demand learning. We specifically examine a trade-off between the quantity of stores tested and the quality of observations, which can be impacted by demand censoring due to inventory stockouts. We find that the visibility into the timing of each sales transaction has a pivotal impact on the allocation decisions that optimize learning. When such timing information is unobservable, the retailer may need to consolidate inventory in few stores to increase service levels during the test and thereby to minimize the negative impacts of demand censoring. When sales timing information is observable, the retailer optimizes learning by maximizing the number of sales during the test period without regard to stockouts in individual stores. In a numerical study, we show that heuristics motivated by our analyses are near optimal and that inefficient allocations can considerably reduce the learning value of the merchandise test. We also examine the interplay between the retailer’s learning incentive and the natural incentives brought by fixed costs and profits earned during the test itself. We find that it is sufficient for the retailer to consider only the learning incentive when the main selling period is relatively long compared with the testing period.The online appendix is available at https://doi.org/10.1287/opre.2017.1596 .
A hematologic scoring system and C-reactive protein compared to blood cultures for diagnosing bacterial neonatal sepsis
Authors: Liestiadi Deddy Eka Febri , Azlin Emil , Nafianti Selvi 
Published: May 2017

Background Neonatal sepsis is the leading cause of death after pneumonia. Definitive bacterial sepsis diagnoses are made by blood culture results, which require a lengthy time. C-reactive protein (CRP) levels and a hematologic scoring system by Rodwell et al. are rapid tests that may be useful for diagnosing neonatal sepsis. Objective To determine the diagnostic value of CRP measurement and a hematologic scoring system compared to blood culture as the gold standard for diagnosing neonatal sepsis. Methods A cross-sectional study was conducted from April to August 2015 in the Neonatology Ward of Haji Adam Malik Hospital, Medan. A total of 43 neonates who were clinically suspected to have sepsis underwent CRP, hematologic scoring, and blood cultures. The IT ratio and procalcitonin indices were also examined. Diagnostic values were analyzed by a 2x2 table.Results Fourteen percent from all sample had positive bacterial culture. The CRP measurements had a sensitivity of 92.8%, specificity of 62%, positive predictive value (PPV) of 54.1%, negative predictive value (NPV) of 94.7%, positive likelihood ratio (PLR) of 2.44, and negative likelihood ratio (NLR) of 0.11. The hematologic scoring system had a sensitivity of 100%, specificity of 82.7%, PPV of 73.6%, NPV of 100%, PLR of 5.78, and NLR of 0. Procalcitonin and IT ratio show a good value of sensitivity and NPV, respectively. Conclusion The hematologic scoring system has better specificity than CRP measurement as compared to blood culture. However, both tests have good sensitivity for diagnosing neonatal sepsis.
Effect of oral administration of probiotics on intestinal colonization with drug-resistant bacteria in preterm infants
Authors: Kurt Abdullah , Ince Deniz Anuk , Ecevit Ayşe , Azap Özlem Kurt , Ecevit Zafer , Öğüş Ersin , Tuğcu Ali Ulaş , Tarcan Aylin 
Published: May 2017

Background Oral administration of probiotics in newborn preterm infants has been shown to be helpful, especially ın reducıng the incidence of necrotizing enterocolitis and overall mortality rates.Objective To evaluate the effect of probıotıc supplementation on ıntestınal colonization by antibiotic-resistant microorganisms in preterm infants receiving antibiotics in a neonatal intensive care unit (NICU).Methods The prospective, randomized trial was performed ın preterm infants who were hospitalized in the NICU at Baskent University Ankara Hospital between January 2011 and February 2012. A total of 51 infants were enrolled and randomly assigned to one of two groups: Group 1 (n=27) received probiotic therapy and Group 2 (n=24) did not receive probiotics. The probiotic used was Lactobacillus reuteri (Biogaia® AB, Sweden). Subjects underwent weekly nasal swab and stool cultures for a maxımum of 6 weeks, and at the tıme of dıscharge ıf thıs was prıor to 6 weeks. All posıtıve cultures were further tested for culture-specıfıc ıdentıfıcatıon and antıbıotıc suceptibility.Results A total of 607 cultures were evaluated. Posıtıve cultures were found ın 37.9% from Group 1 and 35.2% from Group 2. Intestınal colonızatıon by antıbıotıc-resıstant bacterıa dıd not sıgnıfıcantly dıffer between groups (P>0.05). Conclusions Oral supplementation with probiotics do not prevent the intestınal colonization of antibiotic-resistant microorganisms in preterm NICU patıents who receıved antıbıotıc treatment.
Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal
Authors: Streubel Gundula , Fitzpatrick Darren J , Oliviero Giorgio , Scelfo Andrea , Moran Bruce , Das Sudipto , Munawar Nayla , Watson Ariane , Wynne Kieran , Negri Gian Luca , Dillon Eugene T , Jammula SriGanesh , Hokamp Karsten , O'Connor Darran P , Pasini Diego , Cagney Gerard , Bracken Adrian P 
Published: May 2017

AbstractSin3a is the central scaffold protein of the prototypical Hdac1/2 chromatin repressor complex, crucially required during early embryonic development for the growth of pluripotent cells of the inner cell mass. Here, we compare the composition of the Sin3a‐Hdac complex between pluripotent embryonic stem (ES) and differentiated cells by establishing a method that couples two independent endogenous immunoprecipitations with quantitative mass spectrometry. We define the precise composition of the Sin3a complex in multiple cell types and identify the Fam60a subunit as a key defining feature of a variant Sin3a complex present in ES cells, which also contains Ogt and Tet1. Fam60a binds on H3K4me3‐positive promoters in ES cells, together with Ogt, Tet1 and Sin3a, and is essential to maintain the complex on chromatin. Finally, we show that depletion of Fam60a phenocopies the loss of Sin3a, leading to reduced proliferation, an extended G1‐phase and the deregulation of lineage genes. Taken together, Fam60a is an essential core subunit of a variant Sin3a complex in ES cells that is required to promote rapid proliferation and prevent unscheduled differentiation.
Perspektywy dla dziewic konsekrowanych żyjących w świecie wynikające z duchowości monastycznej
Authors: Stypułkowska Beata 
Published: May 2017

W niniejszym artykule została podjęta refleksja nad teraźniejszością dziewic konsekrowanych. Po przedstawieniu specyfiki dziewic konsekrowanych żyjących w świecie została ukazana charakterystyka duchowości monastycznej, ze szczególnym zwróceniem uwagi na brak drugorzędnego celu, uprzywilejowane miejsce modlitwy w życiu mniszym, realizowanej w dwóch formach: modlitwy liturgicznej oraz modlitwy prywatnej, stałość życia we wspólnocie i utrzymywanie się z własnej pracy. Zostało jeszcze zasygnalizowane zagadnienie teologii monastycznej. Wszystkie te aspekty były rozpatrywane w kontekście dziewic konsekrowanych.W części poświęconej modlitwie dziewic konsekrowanych została omówiona modlitwa liturgiczna (msza święta, spowiedź i kierownictwo duchowe, liturgia godzin) i modlitwa prywatna (adoracja Najświętszego Sakramentu, czytanie Pisma Świętego i rozmyślanie, specjalne nabożeństwo do Maryi).Całość artykułu kończą sugestie dla dziewic konsekrowanych inspirowane duchowością monastyczną.
Zmysły duchowe w duchowości chrześcijańskiej
Authors: Zyzak Wojciech 
Published: May 2017

Autor próbuje usystematyzować poglądy chrześcijańskich autorów na temat zmysłów duchowych. Przedstawia teologiczne podstawy teorii zmysłów duchowych, poglądy na ich istnienie, liczbę, hierarchię ważności, naturę i przedmiot. Opiera się głównie na danych Pisma Świętego, ojców Kościoła oraz najważniejszych teologów zajmujących się tym zagadnieniem.
Papieska elekcja i posługa w dokumentach soboru we Florencji
Authors: Medwid Wojciech 
Published: May 2017

Artykuł ma na celu odpowiedzieć na pytanie, w jaki sposób sobór florencki zdefiniował wybór papieża, jego kompetencje i znaczenie przewodnictwa Kościołowi oraz jak papieska funkcja wpłynęła na przezwyciężenie koncyliaryzmu. Sobór pokazał przewodnią rolę papieża nad Kościołem powszechnym i określił konkretne zadania i priorytety biskupa Rzymu oraz procedury jego wyboru. W przypadku wakatu w Stolicy Apostolskiej, który powstałby w trakcie obrad soborowych, wybór nowego biskupa Rzymu miał mieć miejsce tam, gdzie obradują ojcowie. Przed wejściem na konklawe elektorzy mieli złożyć przysięgę Bogu i Kościołowi. Papież jest pierwszym i najwyższym pasterzem owczarni Chrystusa i dlatego musi być osobą zatroskaną o zbawienie wszystkich dusz i o pożytek dla całego świata chrześcijańskiego. Biskup Rzymu ma zdecydowanie wyznawać i zachować wiarę katolicką, według tradycji apostolskiej, soborów powszechnych i świętych ojców. Papież musi być świadomy swojej funkcji i gotowy do największych poświęceń w służbie Bogu i wiernym. Ma także dbać o prowadzenie i kierowanie na drogę zbawienia duchowieństwa i ludu rzymskiego oraz musi naprawiać i usuwać wszystko, co może być skażone symonią lub konkubinatem. Papież nie może kierować się więzami pokrewieństwa, ma być dostępny dla wiernych.