bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Brookite TiO2 Photocatalyzed Degradation of Phenol in Presence of Phosphate, Fluoride, Sulfate and Borate Anions.
Authors: Zhang Xiao , Xiong Xianqiang , Xu Yiming 
Published: September 2016

AbstractPhotocatalytic measurements are carried out with a 1 g/L suspension of brookite TiO2 in presence of PO43‐, F‐, B4O72‐, and SO42‐ as well as 0.43 mmol Ph‐OH (300 W Hg lamp with 3.3 mW/cm2) and 2,4‐dichlorophenol.
ChemInform Abstract: Bimetallic Ag—Cu Alloy Nanoparticles as a Highly Active Catalyst for the Enamination of 1,3‐Dicarbonyl Compounds.
Authors: Rout Lipeeka , Kumar Aniket , Dhaka Rajendra S. , Dash Priyabrat 
Published: September 2016

AbstractThe catalyst is recyclable and reusable at least 4 times.
ChemInform Abstract: The Synthesis of Pyrroles and Oxazoles Based on Gold α‐Imino Carbene Complexes.
Authors: Loy Nicole S. Y. , Choi Subin , Kim Sunggak , Park Cheol‐Min 
Published: September 2016

AbstractCationic gold complexes of α‐oximimino carbenes react with weak nucleophiles including enol ethers and nitriles to provide the highly efficient synthesis of pyrroles and oxazoles.
ChemInform Abstract: Iron(III)‐Catalyzed Carbonyl—Olefin Metathesis.
Authors: Ludwig Jacob R. , Zimmerman Paul M. , Gianino Joseph B. , Schindler Corinna S. 
Published: September 2016

AbstractThe direct carbon—carbon bond construction between carbonyl and olefin moieties relying on iron as an environmentally benign catalyst is established.
ChemInform Abstract: Synthesis of 1,2,3‐Triazolylmethoxyphenyl[1,2,4]triazolo[1,2‐a]indazoletrione Derivatives by Combining Click and Multicomponent Reactions.
Authors: Zolfigol Mohammad Ali , Khazaei Ardeshir , Faal‐Rastegar Toktam , Mallakpour Shadpour , Khavasi Hamid Reza , Salehi Peyman , Fakharian Mahsa 
Published: September 2016

AbstractA one‐pot four‐component reaction between propargylated benzaldehydes, azides, dimedone and urazoles provides the title products in high yields.
ChemInform Abstract: Catalytic, Asymmetric Difluorination of Alkenes to Generate Difluoromethylated Stereocenters.
Authors: Banik Steven M. , Medley Jonathan William , Jacobsen Eric N. 
Published: September 2016

AbstractA new method for the catalytic, asymmetric, migratory geminal difluorination of β‐substituted styrenes to access a variety of products bearing difluoromethylated tertiary or quaternary stereocenters is reported.
ChemInform Abstract: Diastereoselective Radical Hydroacylation of Alkylidenemalonates with Aliphatic Aldehydes Initiated by Photolysis of Hypervalent Iodine(III) Reagents.
Authors: Selvakumar Sermadurai , Sakamoto Ryu , Maruoka Keiji 
Published: September 2016

AbstractThe mild, metal‐free reaction delivers chiral ketones in a highly diastereoselective manner.
ChemInform Abstract: A Multi‐Component Synthesis of Functionalized O,S‐Dialkyldithiocarbonates.
Authors: Patra Gopal C. , Pal Sutanuka , Bhunia Sankar C. , Hazra Nirmal K. , Pal Sudhir C. 
Published: September 2016

AbstractEmploying DABCO as catalyst, primary, secondary, and non‐allylic alcohols are effectively utilized in the synthesis of the title dithiocarbonates under mild reaction conditions.
ChemInform Abstract: Low‐Valent Cobalt‐Catalyzed C—H Allylation.
Authors: Cong Xuefeng , Zhai Shengxian , Zeng Xiaoming 
Published: September 2016

AbstractAn efficient 2‐pyridyl directed C—H allylation of arenes is developed using a Grignard reagent as base and a simple Co(II)‐salt as catalyst.
ChemInform Abstract: Difunctionalization of Alkenes Using 1‐Chloro‐1,2‐benziodoxol‐3‐(1H)‐one.
Authors: Egami Hiromichi , Yoneda Takahiro , Uku Minako , Ide Takafumi , Kawato Yuji , Hamashima Yoshitaka 
Published: September 2016

AbstractOxy‐, di‐ and azidochlorination, chlorothiocyanation and iodoesterification proceed in the presence of Togni reagent Bio‐Cl (XVII) in a site‐selective manner.
ChemInform Abstract: New Benzimidazolium‐Based Chiral Ionic Liquids: Synthesis and Application in Enantioselective Sodium Borohydride Reductions in Water.
Authors: Singh Avtar , Chopra Harish Kumar 
Published: September 2016

AbstractNew chiral ionic liquids with good thermal stability and fluorescence activity are synthesized and employed in enantioselective sodium borohydride reductions of prochiral ketones to optically active alcohols.
ChemInform Abstract: Hofmann Rearrangement of Carboxamides Mediated by N‐Bromoacetamide.
Authors: Jevtic Ivana I. , Dosen‐Micovic Ljiljana , Ivanovic Evica R. , Ivanovic Milovan D. 
Published: September 2016

AbstractThe title reaction is successfully applied to aliphatic and aromatic amides, including diamides.
ChemInform Abstract: Iron‐Catalyzed One‐Pot N‐Aroylation of NH‐Sulfoximines with Methylarenes Through Benzylic C—H Bond Oxidation.
Authors: Muneeswara Madithedu , Kotha Surya Srinivas , Sekar Govindasamy 
Published: September 2016

AbstractThe efficient title reaction tolerates a broad range of functional groups.
ChemInform Abstract: Asymmetric Organocatalytic Assembly of Oxindoles Fused with Spiro‐3,4‐dihydropyrans with Three Contiguous Stereocenters Consisting of Vicinal Quaternary Centers.
Authors: Vishwanath Manjunatha , Vinayagam Poopathy , Gajulapalli V Pratap Reddy , Kesavan Venkitasamy 
Published: September 2016

AbstractAn organocatalytic, inverse‐electron demand hetero‐Diels—Alder reaction of isatylidene β,γ‐unsaturated α‐ketoesters with cyclic β‐oxoaldehydes is developed.
ChemInform Abstract: Sc(OTf)3‐Catalyzed Diastereoselective Formal [3 + 2] Cycloaddition Reactions of Alkynylcyclopropane Ketones with Electron‐Rich Aromatic Aldehydes to Yield 2,5‐trans‐Tetrahydrofurans.
Authors: Zhang Chi , Xu Muyun , Ren Jun , Wang Zhongwen 
Published: September 2016

AbstractFurthermore, the cycloadducts can be converted to polycyclic products such as (XII).
ChemInform Abstract: A Chiral Electrophilic Selenium Catalyst for Highly Enantioselective Oxidative Cyclization.
Authors: Kawamata Yu , Hashimoto Takuya , Maruoka Keiji 
Published: September 2016

AbstractThe first transformation of β,γ‐unsaturated carboxylic acids to γ‐butenolides according to the title reaction is elaborated.
ChemInform Abstract: Cu0‐Promoted Cyclization of Unsaturated α‐Halogeno Amides to Give β‐ and γ‐Lactams.
Authors: Clark Andrew J. , Duckmanton Jonathan N. , Felluga Fulvia , Gennaro Armando , Ghelfi Franco , Hardiman Jack R. D. , Isse Abdirisak A. , Manferdini Claudia , Spinelli Domenico 
Published: September 2016

AbstractGenerally, pyrrolidinones are obtained as products whereas in case of substrate (VI) azetidinones are obtained.
ChemInform Abstract: Visible Light Initiated Hantzsch Synthesis of 2,5‐Diaryl‐Substituted Pyrroles at Ambient Conditions.
Authors: Lei Tao , Liu Wen‐Qiang , Li Jian , Huang Mao‐Yong , Yang Bing , Meng Qing‐Yuan , Chen Bin , Tung Chen‐Ho , Wu Li‐Zhu 
Published: September 2016

AbstractThe key intermediates in this reaction are alkyl radicals generated by single‐electron transfer from the photoexcited catalyst to α‐bromo ketones, which subsequently react with enamines to undergo the Hantzsch reaction rapidly at ambient conditions.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Carbene Insertion into C(sp3)—H Bonds.
Authors: Sole Daniel , Mariani Francesco , Bennasar M.‐Lluisa , Fernandez Israel 
Published: September 2016

AbstractA regioselective Pd‐catalyzed cyclization of α‐diazoesters to N‐arylpyrrolidines is developed.
ChemInform Abstract: 3,4‐Dihydro‐2H‐pyrrole‐2‐carbonitriles: Useful Intermediates in the Synthesis of Fused Pyrroles and 2,2′‐Bipyrroles.
Authors: Nebe Marco M. , Kucukdisli Murat , Opatz Till 
Published: September 2016

AbstractDiarylated cyanopyrrolines are subjected to the reaction with α‐bromo‐ω‐chloroalkanes and dichloroalkene (XI) under different conditions.
ChemInform Abstract: Catalytic Synthesis of 3‐Thioindoles Using Bunte Salts as Sulfur Sources under Metal‐Free Conditions.
Authors: Qi Hong , Zhang Tongxin , Wan Kefeng , Luo Meiming 
Published: September 2016

AbstractThe title protocol is advantageous with respect to the use of odorless and stable Bunte salts as sulfenylating agents and iodine as non metallic catalyst.
ChemInform Abstract: Enantioselective Carbene Cascade: An Effective Approach to Cyclopentadienes and Applications in Diels—Alder Reactions.
Authors: Wang Xiangbo , Zhou Yunfei , Qiu Lihua , Yao Ruwei , Zheng Yang , Zhang Cheng , Bao Xiaoguang , Xu Xinfang 
Published: September 2016

AbstractAn asymmetric carbene cascade reaction, which proceeds through a carbene/alkyne metathesis and a formal [3+2] cycloaddition and converts alkynyl‐tethered enol diazoacetates to chiral bicyclic cyclopentadienes, is presented.
ChemInform Abstract: Synthesis of 9H‐Pyrrolo[1,2‐a]indole and 3H‐Pyrrolizine Derivatives via a Phosphine‐Catalyzed Umpolung Addition/Intramolecular Wittig Reaction.
Authors: Saleh Nidal , Voituriez Arnaud 
Published: September 2016

AbstractOptimized reaction conditions are developed for the title process allowing cyclization reactions of heteroaryl aldehydes (I) or (IV) with acetylene dicarboxylate (II) to form the title products in high yields.
ChemInform Abstract: Regioconvergent and Enantioselective Rhodium‐Catalyzed Hydroamination of Internal and Terminal Alkynes: A Highly Flexible Access to Chiral Pyrazoles.
Authors: Haydl Alexander M. , Hilpert Lukas J. , Breit Bernhard 
Published: September 2016

AbstractThe reaction has a broad substrate scope and tolerates multiple functional groups.
ChemInform Abstract: Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter.
Authors: Vila Carlos , Amr Fares Ibrahim , Blay Gonzalo , Munoz M. Carmen , Pedro Jose R. 
Published: September 2016

AbstractAn asymmetric one‐pot reaction between isatin‐derived ketimines and pyrazolones provides the title products in high yields and with very high enantioselectivities.
ChemInform Abstract: Stereoselective anti‐Markovnikov Geminal Diamination and Dioxygenation of Vinylarenes Mediated by the Bromonium Ion.
Authors: Balaji Pandur Venkatesan , Chandrasekaran Srinivasan 
Published: September 2016

AbstractThe geminal dioxygenation of styrenes with 1,2‐ and 1,3‐diols is achieved in the presence of NBS/AgOTf as oxidant to give dioxoheterocycles completely stereoselectively.
ChemInform Abstract: Regiodivergent Cross‐Dehydrogenative Coupling of Pyridines and Benzoxazoles: Discovery of Organic Halides as Regio‐Switching Oxidants.
Authors: Yamada Shuya , Murakami Kei , Itami Kenichiro 
Published: September 2016

AbstractThe use of organic halides as oxidants to achieve the cross‐dehydrogenative coupling reaction of two unfunctionalized heteroarenes (pyridines and benzoxazoles) with palladium catalyst is described.
ChemInform Abstract: DBU‐Mediated [3 + 2] Cycloaddition Reactions of Donor—Acceptor Cyclopropanes with Nitromethane: Efficient Strategy for the Construction of Isoxazole Skeletons.
Authors: Xue Shuwen , Liu Jiaming , Wang Cunde 
Published: September 2016

AbstractIn addition to nitromethane other nitro compounds are employed.
ChemInform Abstract: Visible Light Triggered, Catalyst Free Approach for the Synthesis of Thiazoles and Imidazo[2,1‐b]thiazoles in EtOH : H2O Green Medium.
Authors: Mishra Anu , Srivastava Madhulika , Rai Pratibha , Yadav Snehlata , Tripathi Bhartendu Pati , Singh Jaya , Singh Jagdamba 
Published: September 2016

AbstractThe title synthesis from phenacyl bromide and thioureas or 2‐amino thiazoles features catalyst free, no additional oxidants, short reaction time, and excellent yields.
ChemInform Abstract: Transition Metal‐Free Steric Controlled One‐Pot Synthesis of Highly Substituted N‐Amino 1,2,3‐Triazole Derivatives via Diazo Transfer Reaction from β‐Keto Esters.
Authors: Nagarajan Rajendran , Jayashankaran Jayadevan , Emmanuvel Lourdusamy 
Published: September 2016

AbstractDiazo transfer to in situ generated hydrazones using imidazosulfonyl azide as reagent results in the formation of 1,2,3‐triazoles in good yields.
ChemInform Abstract: Synthesis of Novel Polycyclic Heterosystems Based on 5‐Nitro[1,2,5]thiadiazolo[3,4‐e]benzofuroxan.
Authors: Starosotnikov Aleksei M. , Bastrakov Maxim A. , Pavlov Alexander A. , Fedyanin Ivan V. , Dalinger Igor L. , Shevelev Svyatoslav A. 
Published: September 2016

AbstractComplex polycyclic compounds with potential NO‐donor activity are prepared utilizing Diels—Alder and Michael reactions.
ChemInform Abstract: Synthesis of 4‐(Alkoxyamino)chroman‐2‐ones via 6‐exo‐trig Cyclization of Carbon‐Centered Radicals into Oxime Ethers.
Authors: Bejarano Carlos A. , Diaz John E. , Loaiza Alix E. 
Published: September 2016

AbstractThe synthesis of the title chromanones leads to reasonably good yields and diastereoselectivity, when precursors contain a secondary alkyl bromide.
ChemInform Abstract: Access to 4,6‐Diarylpicolinates via a Domino Reaction of Cyclic Sulfamidate Imines with Morita—Baylis—Hillman Acetates of Nitroolefins/Nitrodienes.
Authors: Majee Debashis , Biswas Soumen , Mobin Shaikh M. , Samanta Sampak 
Published: September 2016

AbstractThe title process is advantageous with regards to operational simplicity, high yields and good functional group tolerance.
ChemInform Abstract: Base‐Mediated Synthesis of Highly Functionalized 2‐Aminonicotinonitriles from α‐Keto Vinyl Azides and α,α‐Dicyanoalkenes.
Authors: Shu Ke , Shao Jiaan , Li Hong , Chen Binhui , Tang Pai , Liu Xingyu , Chen Wenteng , Yu Yongping 
Published: September 2016

AbstractThe possible mechanism of the title synthesis involves not only the formation of 2H‐azirine from the thermolysis of vinyl azide and vinylogous carbanion from dicyanoalkene, but also an intramolecular nucleophilic attack between the nitrogen of the aziridine and a cyano group followed by cyclization, ring‐opening, and intramolecular rearrangement.
ChemInform Abstract: Gold(I) Catalyzed Tandem Cyclization of Propargylic Esters to 4‐Acyloxy‐1,2‐dihydroquinolines.
Authors: Sun Yuan‐Ming , Gu Peng , Gao Yu‐Ning , Xu Qin , Shi Min 
Published: September 2016

AbstractA facile method to synthesize 4‐acyloxy‐1,2‐dihydroquinolines is established through a gold(I)‐catalyzed tandem [3,3]‐rearrangement and intramolecular hydroamination of propargylic esters, giving the desired products in good yields under mild conditions.
ChemInform Abstract: Copper‐Catalyzed Intermolecular Amidation of 8‐Methylquinolines with N‐Fluoroarylsulfonimides via Csp3—H Activation.
Authors: Zhang Xiaolei , Wu Rui , Liu Wanyi , Qian Dang‐Wei , Yang Jinhui , Jiang Pengju , Zheng Qing‐Zhong 
Published: September 2016

AbstractThe reaction tolerates various functional groups and does not require an additional oxidant.
ChemInform Abstract: Pyridofuropyrrolo[1,2‐a]pyrimidines and Pyridofuropyrimido[1,2‐a]azepines: New Chemical Entities (NCE) with Anticonvulsive and Psychotropic Properties.
Authors: Sirakanyan Samvel N. , Geronikaki Athina , Spinelli Domenico , Paronikyan Ruzanna G. , Dzhagatspanyan Irina A. , Nazaryan Ivetta M. , Akopyan Asmik H. , Hovakimyan Anush A. 
Published: September 2016

AbstractThe title compounds are easily synthesized from furo[2,3‐b]pyridines using POCl3 as the reagent.
ChemInform Abstract: Catalyst and Solvent Free One‐Pot Microwave Synthesis of Fused Pyrimidine Diones and Triones.
Authors: Sontakke Madhuri M. , Dhonde Madhukar G. , Bhaskar Chandrakant S. , Berad Baliram N. 
Published: September 2016

AbstractThe title diones and triones are prepared by one‐pot three‐component condensation of barbituric acids, various aldehydes, and carbamides or thiocarbamides under mild reaction conditions.
ChemInform Abstract: Synthesis of Alkenylboronic Esters: An Alternative Route to Trisubstituted Homoallylic Alcohols.
Authors: Gehrke Yvonne , Berg Christina Annette , Vahabi Roza , Pietruszka Joerg 
Published: September 2016

AbstractBromoboration and subsequent reaction with optically active diol (II) provides 2‐bromo substituted alkenylboronic esters (III).
ChemInform Abstract: Palladium‐Catalyzed Oxidative Carbocyclization—Borylation of Enallenes to Cyclobutenes.
Authors: Qiu Youai , Yang Bin , Zhu Can , Baeckvall Jan‐E. 
Published: September 2016

AbstractEfficient reaction conditions are developed for the Pd‐catalyzed oxidative carbocyclization‐borylation of enallenes to allow the selective formation of cyclobutenes.
ChemInform Abstract: The Drastic Effect of Cobalt and Chromium Catalysts in the Borylation of Arylzinc Reagents.
Authors: Komeyama Kimihiro , Kiguchi Shinnosuke , Takaki Ken 
Published: September 2016

AbstractA drastic additive effect for increasing the reactivity of arylzinc reagents, enabling the borylation of unreactive arylzinc compounds to afford various arylboronic esters is reported.
ChemInform Abstract: Chemoselective Cu(I) Catalyzed Bis(pinacolato)diboron Conjugate Addition and Reduction onto α,β‐Unsaturated Carbonyl Compounds.
Authors: Wang Qing‐Dong , Yang Jin‐Ming , Fang Dong , Ren Jiangmeng , Dong Bin , Zhou Bin , Zeng Bu‐Bing 
Published: September 2016

AbstractThe conversion of ketones (I) into addition products (III) and hydrogenation products (IV) is controlled by the base used.
ChemInform Abstract: Wet‐Chemical Preparation of Barium Magnesium Orthophosphate, Ba2Mg(PO4)2:Eu2+, Nanorod Phosphor with Enhanced Optical and Photoluminescence Properties.
Authors: Song Hee Jo , Lee Chan Woo , Hwang Sung Won , Cho In Sun 
Published: September 2016

AbstractYellow‐emitting nanorod phosphors Ba2‐2xMg(PO4)2:Eu2x2+ (x = 0.01—0.09) are precipitated from stoichiometric aqueous solutions of Ba(NO3)2, Mg(NO3)2, (NH4)2HPO4, and Eu2O3 (pH 7—11 adjusted with NaOH, 90 °C, 6 h) followed by annealing (5%H2/N2, 600—800 °C, 2 h).
ChemInform Abstract: Synthesis of Composition Tunable and Highly Luminescent Cesium Lead Halide Nanowires Through Anion‐Exchange Reactions.
Authors: Yang Peidong , et al.  
Published: September 2016

AbstractMonodisperse CsPbX3 (X: Cl, Br, I) nanowires (NWs) are prepared by injecting octylamine (OAm) and octadecene (ODE) into a 120 °C solution of PbBr2 in octadecene under N2 (135 °C, 35 min) to which a solution of Cs oleate is quickly added (40‐60 min; cooling to 0 °C).
ChemInform Abstract: Intracell Hydrogen Adsorption‐Transmission in a Co2P Solid Hydrogen‐Storage Material.
Authors: Bao Di , Gao Peng , Li Chenliang , Wu Guoxun , Wang Yanbo , Chen Yujin , Zhou Han , Yang Piaoping 
Published: September 2016

AbstractCo2P nanoparticles are obtained by ball milling (600 rpm, 6 h) of stoichiometric amounts of Co and red P under argon.
Overview of Critical Parameters for the Design and Execution of a High‐Throughput Screen for Allosteric Ligands
Authors: Alt Andrew 
Published: September 2016

AbstractAllosteric ligands modulate the activity of receptor targets by binding to sites that are distinct from the orthosteric (native agonist) binding site. Allosteric modulators have potential therapeutic advantages over orthosteric agonists and antagonists, including improved selectivity, and maintenance of the spatial and temporal fidelity of native signaling patterns. The identification of allosteric ligands presents unique challenges because of the requirement for screening in the presence of an orthosteric agonist, the small signal window that is produced by many allosteric modulators, the proclivity of allosteric modulators to exhibit activity switching within a chemotype (e.g., one compound may be a positive allosteric modulator while a close analog is a negative allosteric modulator), and probe dependence (differential interactions with different orthosteric agonists). Described in this unit are emerging strategies for the identification of allosteric ligands by high‐throughput screening (HTS), including the use of multiple‐add/multiple‐read HTS assays and tool molecule‐based screening formats. © 2016 by John Wiley & Sons, Inc.
Delay‐locked loop based clock and data recovery with wide operating range and low jitter in a 65‐nm CMOS process
Authors: Wang Yuan , Liu Yuequan , Jia Song , Zhang Xing 
Published: September 2016

SummaryA delay‐locked loop (DLL) based clock and data recovery (CDR) circuit with a half‐rate clock is proposed. The CDR includes a coarse and a fine tuned block, in which the novel coarse and fine phase detectors form closed loops. It is designed in a 65‐nm complementary metal‐oxide semiconductor (CMOS) process using a 1.2‐V supply voltage. The simulation results show that it can cover a wide operating range from 500 Mbps to 8 Gbps and the corresponding peak‐to‐peak jitters are 1.63 ps and 0.96 ps, respectively. Copyright © 2016 John Wiley & Sons, Ltd.
New Horizons in Pediatric Psychopharmacology
Authors: Khan Sarah , Rathore Vijaylaxmi , Khan Shahida 
Published: September 2016

ABSTRACT

Preclinical Research

Recent advances in pediatric psychopharmacology have been rather uneven. Increased use of psychotropic drugs among the pediatric population has raised concerns regarding their inappropriate use and safety. While clinical trials have been conducted on various pediatric psychopharmacological drugs, there has been an insignificant amount of importance to innovation in holistic treatment. A rational approach toward elucidating the various challenges would be contingent on the convergence of the development of novel efficacious psychotropic drugs with concrete conceptual frameworks and guidelines fostering enhanced outcomes. A research infrastructure concerning the relevance of the clinician's perspective, combining drugs with alternative therapies, the need for pediatric specific formulations and relevance of these in developing countries provides a basis on which innovative treatment/development can be constructed. The current commentary highlights these comprehensive and targeted treatment guidelines as aspects necessary for building the future of the field. Drug Dev Res 77 : 474–478, 2016. © 2016 Wiley Periodicals, Inc.
Improving Current Treatments for Schizophrenia
Authors: Maric Nadja P. , Jovicic Milica J. , Mihaljevic Marina , Miljevic Cedo 
Published: September 2016

ABSTRACT

Preclinical Research

After the identification of the schizophrenia as an illness over a century ago, treatment of affected individuals included unspecific, mostly very robust methods including deep insulin coma and lobectomy/leucotomy. The first relatively specific treatment of schizophrenia started about 60 years ago with the antipsychotic chlorpromazine. All currently approved antipsychotic drugs block dopamine receptors, indicating that manipulation of dopaminergic function is fundamental to a therapeutic response in psychosis. Despite refinements in their mechanism of action, the therapeutic effects of subsequent generations of antipsychotics are insufficient in claiming superiority over the first generation, with the possible exception of clozapine. Dopamine receptor blockade is necessary but not always sufficient for antipsychotic response and improvements have been reported with molecules acting on other receptors (glutamate, glycine, cannabidiol, estrogen), intracellular signaling proteins, or products of identified risk genes. Here, we review the current status of drugs under investigation. In addition, we emphasize that the development of the novel compounds to target the underlying cognitive dysfunction and negative symptom dimension of full blown schizophrenia, or attenuated psychosis syndrome and specific endophenotypes related to the increased risk of psychosis in the general population, alongside efforts to deconstruct the concept of schizophrenia(s), represent the best way to meet patient needs for better therapies and more favorable outcomes. Drug Dev Res 77 : 357–367, 2016. © 2016 Wiley Periodicals, Inc.