bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of parameter estimation in hepatitis C viral dynamics models
Authors: Arthur Joseph G. , Tran Hien T. , Aston Philip 
Published: February 2016

Abstract
Methodologies are presented for assessing the feasibility of parameter estimation in nonlinear ordinary differential equation (ODE) models. These methods are applied to a recent model for hepatitis C viral dynamics. Subset selection is performed on the model parameters, and maximum likelihood estimation is conducted using available data from the literature.
A Cognitive Theory-based Opportunistic Resource-Pooling Scheme for Ad hoc Networks
Authors: Hegde Seema B. , Babu B. Satish , Venkataram Pallapa 
Published: February 2016

AbstractResource pooling in ad hoc networks deals with accumulating computing and network resources to implement network control schemes such as routing, congestion, traffic management, and so on. Pooling of resources can be accomplished using the distributed and dynamic nature of ad hoc networks to achieve collaboration between the devices. Ad hoc networks need a resource-pooling technique that offers quick response, adaptability, and reliability. In this context, we are proposing an opportunistic resource-pooling scheme that uses a cognitive computing model to accumulate the resources with faster resource convergence rate, reliability, and lower latency. The proposed scheme is implemented using the behaviors-observations-beliefs cognitive model, in which the resource-pooling decisions are made based on accumulated knowledge over various behaviors exhibited by nodes in ad hoc networks.
Determination of antepartum and intrapartum risk factors associated with neonatal intensive care unit admission
Authors: Burgess Angela P.H. , Katz Justin , Pessolano Joanna , Ponterio Jane , Moretti Michael , Lakhi Nisha A. 
Published: February 2016

AbstractTo determine antepartum and intrapartum factors that are associated with admission to neonatal intensive care unit (NICU) among infants delivered between 36.0 and 42.0 weeks at our institution.The retrospective cohort study included 73 consecutive NICU admissions and 375 consecutive non-NICU admissions. Data on demographic, antepartum, intrapartum and neonatal factors were collected. The primary endpoint defined was admission to NICU. Univariate analyses using the Student’sThose with a significantly higher risk of NICU admission underwent induction of labor with prostaglandin analogs (12.5% vs. 24.7%, P=0.007). Length of first stage ≥720 min (33.5% vs. 51.9%, P=0.011), length of second stage of labor ≥240 min (10.6% vs. 31.6%, P<0.001) and prolonged rupture of membranes ≥120 min (54.0% vs. 80.0%, P=0.001) were all associated with an increased chance of NICU admission. Intrapartum factors predictive of NICU admission included administration of meperidine (11.7% vs. 27.4%, P<0.001), presence of preeclampsia (5.5% vs. 0.8%, P=0.015), use of intrapartum IV antihypertensives (1.1% vs. 13.7%, P<0.001), maternal fever (5.3% vs. 31.5%, P<0.001), fetal tachycardia (1.9% vs. 12.3%, P<0.001), and presence of meconium (30% vs. 8%, P<0.001).Identification of modifiable risk factors may reduce neonatal morbidity and mortality. Results from this study can be used to develop and validate a risk model based on combined antepartum and intrapartum risk factors.
Crystal structure of succinic acid — 4-((pyridin-4-ylmethyl)sulfanylpyridine (1/1), C15H16N2O4S
Authors: Wang Zhi-Peng , Zhang Fan , Zhang Qi-Qi , Sun Xin-Zhan 
Published: February 2016

Abstract
C15H16N2O4S, triclinic, P1̅ (no. 2), a = 7.3024(6) Å, b = 10.7115(7) Å, c = 11.2743(6) Å, α = 109.491(5)°, β = 100.496(5)°, γ = 107.860(5)°, V = 750.44(9) Å3, Z = 2, R
gt
(F) = 0.0691, wR
ref
(F
2
) = 0.2136, T = 296 K.
Crystal structure of aquabis(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydroquinoline-3-carboxylato-κ2
O,O′)copper(II) thiophene-2,5-dicarboxylate trihydrate, [Cu(C17H18N3FO3)2(H2O)](C6H2SO4)·3(H2O)
Authors: Fan Zhuo-Wen , Li Long , Wang Liang-Liang , Liu Ji-Zhi 
Published: February 2016

Abstract
C40H46Cu1N6O14F2S, monoclinic, P21/c, a = 15.6688(5) Å, b = 14.2411(4) Å, c = 22.0126(10) Å, β = 124.327(3)°, V = 4056.4(3) Å3, Z = 4, R
gt
(F) = 0.0579, wR
ref
(F
2
) = 0.1677, T = 293 K.
Crystal structure of trans-bis(2-methylmaleato-κ
2O,O′) bis(piperazinium-κ
N) cobalt(II) trihydrate, C18H36CoN4O11
Authors: Kang Jaeun , Ok Kang Min , Do Junghwan 
Published: February 2016

Abstract
C18H36CoN4O11, monoclinic, C2/c (no. 15), a = 19.3607(4) Å, b = 13.4260(3) Å, c = 11.2917(2) Å, β = 125.299(1), V = 2395.50(8) Å3, Z = 4, R
gt
(F) = 0.0251, wR
ref
(F2) = 0.0719, T = 123 K.
Urban Policy in Election Campaigns – The Case of the Presidents of the Biggest Cities of Lower Silesia
Authors: Glinka Kamil 
Published: February 2016

Abstract
The main aim of the article is to present the relationship between urban policy and the marketing activity of the presidents of Wrocław, Wałbrzych, Legnica, and Jelenia Góra during the period of the 2014 local government election campaign. Analysis of the marketing activity of the presidents, conducted via chosen social media, enables presentation of the most important conditions and reasons for using urban policy in the competition for the support of citizens – potential voters. First, it will show that the marketing actions of a president during an election campaign are not the means of creating the image of a city but gaining the support of voters. Second, the analysis will prove that the election message constructed by presidents is based on the actions conducted in the various areas of urban policy.
Issues relating to classification of colluvial soils in young morainic areas (Chełmno and Brodnica Lake District, northern Poland)
Authors: Świtoniak Marcin 
Published: February 2016

Abstract
Colluvial soils (in Polish: gleby deluwialne) are an important part of the soil cover in young morainic landscapes of northern Poland. They evolved as a result of the accumulation of eroded material at the foot of the slopes and bottoms of closed depressions. The aim of this study was to determine the systematic position of colluvial soils commonly found in the Chełmno and Brodnica Lake District, northern Poland. Ten soil pits located in different types of landscapes were selected for testing soil properties. The colluvial material is characterized by diversified properties: thickness, particle-size distribution, organic carbon content, color, pH, and base saturation. As a result, the investigated soils represent broad spectrum of typological units according to Polish Soil Classification (2011). Some of them contain epipedons mollic and meet the criteria of colluvial chernozemic soils. They were found mainly on buried black earths in areas with small slope inclinations. Many pedons contain pale colored acidic colluvial material with low base saturation and low organic carbon content and must be classified as other types: arenosols (in Polish: arenosole) or rusty soils (in Polish: gleby rdzawe). These soils occur mostly in areas with intensive relief and overlay the different soil types, including rusty soil and organic soils. They are formed as a result of soils lessivés and rusty soils truncation. An introduction of the additional units of “proper colluvial soils” which have epipedon ochric, and “rusty-colluvial soils” with endopedon sideric to the next edition of Polish Soil Classification would enable a more precise expression of the genesis of these soils in the type rank. Moreover, the definition of chernozemic colluvial soils could be extended to colluvial soils with umbric horizon. Classifying soils derived from colluvial material as soils of other types leads to the disappearance of this units on maps and underestimation of the impact of denudation on the soil cover.
A Numerical Study for the Relationship between Natural Manganese Dendrites and DLA Patterns
Authors: Ozbey Tugba , Bayirli Mehmet 
Published: February 2016

Abstract
The formation mechanisms and the origin of manganese dendrites on the magnesite ore have been under discussion. The growth process of the manganese dendrites is statistically studied by comparing them to aggregations obtained according to the diffusion limited aggregation (DLA) model via Monte Carlo simulations. In this case, ten manganese dendrite patterns changing from the least dense to the densest aggregations on the surface are separately selected to determine the relationship between real and simulated patterns. The sticking parameter is ranged from 0.05≤t≤1. The density–density correlation functions C(r) (their critical exponent A), fractal dimension D

f
, critical exponent α, and critical exponent β pertaining to the root mean square (rms) thickness have been computed for both the ten manganese dendrites and the simulated aggregations representing them. The results indicate that manganese dendrites may be determined with the general DLA model. Analyses of manganese dendrites, both scaling and simulations, suggest the growth mechanism for the macroscopic expression of crystalline anisotropy for the dendritic patterns. These results are in good agreement with the values in other literature and can be helpful in comparing natural and simulated aggregations (both dendritic and compact deposits).
Anaemia (thalassaemia) in the Middle Euphrates Valley of Syria in the second–fourth centuries AD?
Authors: Tomczyk Jacek , Palczewski Piotr , Mańkowska-Pliszka Hanna , Płoszaj Tomasz , Jędrychowska-Dańska Krystyna , Witas Henryk W. 
Published: February 2016

Abstract
REM Sleep Is Causal to Successful Consolidation of Dangerous and Safety Stimuli and Reduces Return of Fear after Extinction
Authors: Menz Mareike M. , Rihm Julia S. , Büchel Christian 
Published: February 2016

Sleep has a profound impact on memory consolidation. In this study, human participants underwent Pavlovian conditioning and extinction before we manipulated nocturnal memory consolidation by a split-night protocol with 80 healthy male participants in four groups. Recall after a second (recovery) night of sleep revealed that sleeping the first half of the night, which is dominated by slow-wave sleep, did not improve recall. Conversely, sleeping the second half of the night, which is dominated by rapid eye movement (REM) sleep, led to better discrimination between fear-relevant and neutral stimuli in behavioral and autonomic measures. Meanwhile, staying awake in the second half of the night led to an increase of discrimination between extinguished and neutral stimuli, which was paralleled by an activation of the ventromedial prefrontal cortex and amygdala. We conclude that sleep, especially REM sleep, is causal to successful consolidation of dangerous and safety stimuli and reduces return of fear after extinction.SIGNIFICANCE STATEMENTWe use a split-night protocol to investigate the influence of different sleep phases on successful consolidation of conditioned fear and extinction. Such a protocol uses the fact that in humans the first half of the night is dominated by slow-wave sleep, whereas during the second half, rapid eye movement (REM) sleep is more predominant. Our data show that only REM-rich sleep during the second half of the night promoted good discrimination between fear-relevant and neutral stimuli during recall, while staying awake led to a recovery of discrimination between extinguished and neutral stimuli. This suggests that sleep following extinction contributes independently to successful extinction memory consolidation.
Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives
Authors: Vyklicky Vojtech , Smejkalova Tereza , Krausova Barbora , Balik Ales , Korinek Miloslav , Borovska Jirina , Horak Martin , Chvojkova Marketa , Kleteckova Lenka , Vales Karel , Cerny Jiri , Nekardova Michaela , Chodounska Hana , Kudova Eva , Vyklicky Ladislav 
Published: February 2016

PostsynapticN-methyl-d-aspartate receptors (NMDARs) phasically activated by presynaptically released glutamate are critical for synaptic transmission and plasticity. However, under pathological conditions, excessive activation of NMDARs by tonically increased ambient glutamate contributes to excitotoxicity associated with various acute and chronic neurological disorders. Here, using heterologously expressed GluN1/GluN2A and GluN1/GluN2B receptors and rat autaptic hippocampal microisland cultures, we show that pregnanolone sulfate inhibits NMDAR currents induced by a prolonged glutamate application with a higher potency than the NMDAR component of EPSCs. For synthetic pregnanolone derivatives substituted with a carboxylic acid moiety at the end of an aliphatic chain of varying length and attached to the steroid skeleton at C3, the difference in potency between tonic and phasic inhibition increased with the length of the residue. The steroid with the longest substituent, pregnanolone hemipimelate, had no effect on phasically activated receptors while inhibiting tonically activated receptors. In behavioral tests, pregnanolone hemipimelate showed neuroprotective activity without psychomimetic symptoms. These results provide insight into the influence of steroids on neuronal function and stress their potential use in the development of novel therapeutics with neuroprotective action.SIGNIFICANCE STATEMENTSynaptic activation ofN-methyl-d-aspartate receptors (NMDARs) plays a key role in synaptic plasticity, but excessive tonic NMDAR activation mediates excitotoxicity associated with many neurological disorders. Therefore, there is much interest in pharmacological agents capable of selectively blocking tonically activated NMDARs while leaving synaptically activated NMDARs intact. Here, we show that an endogenous neurosteroid pregnanolone sulfate is more potent at inhibiting tonically than synaptically activated NMDARs. Further, we report that a novel synthetic analog of pregnanolone sulfate, pregnanolone hemipimelate, inhibits tonic NMDAR currents without inhibiting the NMDAR component of the EPSC and shows neuroprotective activityin vivowithout inducing psychomimetic side effects. These results suggest steroids may have a clinical advantage over other known classes of NMDAR inhibitors.
Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice
Authors: Tong Leslie M. , Yoon Seo Yeon , Andrews-Zwilling Yaisa , Yang Alyssa , Lin Victoria , Lei Hanci , Huang Yadong 
Published: February 2016

Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease (AD). However, the underlying mechanisms are still poorly understood. We previously reported that female apoE4 knock-in (KI) mice had an age-dependent decline in hilar GABAergic interneurons that correlated with the extent of learning and memory deficits, as determined by Morris water maze (MWM), in aged mice. Enhancing GABA signaling by treating aged apoE4-KI mice with the GABAAreceptor potentiator pentobarbital (PB) for 4 weeks before and during MWM rescued the learning and memory deficits. Here, we report that withdrawal of PB treatment for 2 weeks before MWM abolished the rescue in aged apoE4-KI mice, suggesting the importance of continuously enhancing GABA signaling in the rescue. However, treating apoE4-KI mice during middle adulthood (9–11 months of age) with PB for 6 weeks prevented age-dependent hilar GABAergic interneuron decline and learning and memory deficits, when examined at 16 month of age. These data imply that increasing inhibitory tone after substantial GABAergic interneuron loss may be an effective symptomatic, but not a disease-modifying, treatment for AD related to apoE4, whereas a similar intervention before substantial interneuron loss could be a disease-modifying therapeutic.SIGNIFICANCE STATEMENTWe previously reported that female apoE4-KI mice had an age-dependent decline in hilar GABAergic interneurons that correlated with the extent of cognitive deficits in aged mice. The current study demonstrates that enhancing GABA signaling by treating aged apoE4-KI mice with a GABAAreceptor potentiator pentobarbital (PB) before and during behavioral tests rescued the cognitive deficits; but withdrawal of PB treatment for 2 weeks before the tests abolished the rescue, suggesting the importance of continuously enhancing GABA signaling. However, treating apoE4-KI mice during middle adulthood with PB for a short period of time prevented age-dependent hilar GABAergic interneuron decline and cognitive deficits late in life, suggesting early intervention by enhancing GABA signaling as a potential strategy to prevent AD related to apoE4.
Use of botulinum toxin type A for the treatment of radiation therapy–induced myokymia and neuromyotonia in a dog
Authors: Rogatko Cleo P. , Glass Eric N. , Kent Marc , Hammond James J. , de Lahunta Alexander 
Published: February 2016

Abstract
CASE DESCRIPTION A 5-year-old castrated male Maltese was evaluated for intermittent clinical signs of muscle cramping and abnormal movements of the skin of the right pelvic limb at the site where an infiltrative lipoma had twice been resected. After the second surgery, the surgical field was treated with radiation therapy (RT). The clinical signs developed approximately 14 months after completion of RT.
CLINICAL FINDINGS When clinical signs were present, the right biceps femoris and semitendinosus muscles in the area that received RT were firm and had frequently visible contractions, and the skin overlying those muscles had episodic vermiform movements. Electromyography of those muscles revealed abnormal spontaneous activity with characteristics consistent with myokymic discharges and neuromyotonia. Magnetic resonance imaging of the affected leg revealed no evidence of tumor regrowth. The myokymia and neuromyotonia were considered secondary to RT.
TREATMENT AND OUTCOME 4 U of Clostridium botulinum toxin type A (BoNT-A) neurotoxin complex was injected into the affected muscles at each of 6 sites twice during a 24-hour period (ie, 48 U of BoNT-A were administered). The clinical signs were completely resolved 10 days after BoNT-A treatment and were controlled by repeated BoNT-A treatment every 3 to 4 months for > 1 year.
CLINICAL RELEVANCE To our knowledge, this is the first report of myokymia and neuromyotonia secondary to RT in a dog. For the dog of this report, injection of BoNT-A into the affected muscles was safe, effective, and easy to perform.
Urinary bladder retroversion and neourethrocystostomy for treatment of inadvertent prostatectomy and urethrectomy in a dog
Authors: Flesher Kathryn , Weisse Chick , Berent Allyson , Lin Rebecca 
Published: February 2016

Abstract
CASE DESCRIPTION A 15-month-old male Newfoundland was examined because of an inability to urinate, lethargy, inappetence, and intermittent vomiting that first became evident after bilateral cryptorchidectomy 2 days previously. The patient was referred for further evaluation and treatment.
CLINICAL FINDINGS Results of physical examination, serum biochemical analysis, and abdominocentesis led to a diagnosis of uroperitoneum. Retrograde cystography indicated urinary tract obstruction. In view of the history of recent elective cryptorchidectomy, a diagnosis of uroperitoneum with urethral obstruction secondary to iatrogenic prostatectomy and urethrectomy was made.
TREATMENT AND OUTCOME During a ventral midline celiotomy, the inadvertent prostatectomy and urethrectomy were found to have resulted in insufficient urethral length for primary repair. Surgical repair of the urethral defect was achieved by means of a novel technique of bladder retroversion and neourethrocystostomy at the apex of the bladder. A urethral stricture evident 1.5 months after surgery was initially treated with balloon dilatation, followed by temporary and then permanent placement of a self-expanding metallic stent. At the last follow-up 6.6 years after stent placement, the dog remained continent while receiving phenylpropanolamine and the owner was highly satisfied with the outcome.
CLINICAL RELEVANCE Caudal intraabdominal bladder retroversion with apex neourethrocystostomy may be a viable alternative to more complex urethral lengthening procedures in dogs and can potentially preserve lower urinary tract function. This treatment might be considered for patients with urethral trauma or malignant neoplasia necessitating extensive urethral resection. Urethral strictures may be effectively managed with stenting.
The Use of Video-Tacheometric Technology for Documenting and Analysing Geometric Features of Objects
Authors: Woźniak Marek , Świerczyńska Ewa , Jastrzębski Sławomir 
Published: February 2016

Abstract
This paper analyzes selected aspects of the use of video-tacheometric technology for inventorying and documenting geometric features of objects. Data was collected with the use of the video-tacheometer Topcon Image Station IS-3 and the professional camera Canon EOS 5D Mark II. During the field work and the development of data the following experiments have been performed: multiple determination of the camera interior orientation parameters and distortion parameters of five lenses with different focal lengths, reflectorless measurements of profiles for the elevation and inventory of decorative surface wall of the building of Warsaw Ballet School. During the research the process of acquiring and integrating video-tacheometric data was analysed as well as the process of combining “point cloud” acquired by using video-tacheometer in the scanning process with independent photographs taken by a digital camera. On the basis of tests performed, utility of the use of video-tacheometric technology in geodetic surveys of geometrical features of buildings has been established.
CCD MEASUREMENTS OF DOUBLE AND MULTIPLE STARS AT NAO ROZHEN AND ASV IN 2013 AND 2014. EIGHT LINEAR SOLUTIONS*
Authors: Cvetković Z. , Pavlović R. , Boeva S. 
Published: February 2016

ABSTRACT
Using the 2 m telescope of the Bulgarian National Astronomical Observatory at Rozhen, observations of 271 double or multiple stars were carried out during seven nights in 2013 and 2014. This is the eighth series of measurements of CCD frames of double and multiple stars obtained at Rozhen. Also in 2013 and 2014, using the 0.6 m telescope of the Serbian Astronomical Station on the mountain of Vidojevica, observations of 343 double or multiple stars were carried out during 21 nights. This is the third series of measurements of CCD frames of double and multiple stars obtained at this station. In this paper, we present the results for the position angle and angular separation for 721 pairs and residuals for 126 pairs with published orbital elements or linear solutions. These observations have angular separations in the range from 1.″24 to 202.″30, with a median angular separation of 7.″17. We also present eight linear solutions that have been calculated for the first time.