bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients
Authors: Yu Li-Rong , Cao Zhijun , Makhoul Issam , Daniels Jaclyn R , Klimberg Suzanne , Wei Jeanne Y , Bai Jane PF , Li Jinong , Lathrop Julia T , Beger Richard D , Todorova Valentina K 
Published: December 2017

Cancer treatment with doxorubicin (DOX) can induce cumulative dose-dependent cardiotoxicity. Currently, there are no specific biomarkers that can identify patients at risk during the initial doses of chemotherapy. The aim of this study was to examine plasma cytokines/chemokines and potential cardiovascular biomarkers for the prediction of DOX-induced cardiotoxicity. Plasma samples were collected before (T0), and after the first (T1) and the second (T2) cycles of DOX-based chemotherapy of 27 breast cancer patients, including five patients who presented with >10% decline of left ventricular ejection fraction (LVEF), five patients with LVEF decline of 5–10%, and 17 patients who maintained normal LVEF at the end of chemotherapy (240 mg/m2 cumulative dose of DOX from four cycles of treatment). Multiplex immunoassays were used to screen plasma samples for 40 distinct chemokines, nine matrix metalloproteinases, 33 potential markers of cardiovascular diseases, and the fourth-generation cardiac troponin T assay. The results showed that the patients with abnormal decline of LVEF (>10%) had lower levels of CXCL6 and sICAM-1 and higher levels of CCL23 and CCL27 at T0; higher levels of CCL23 and lower levels of CXCL5, CCL26, CXCL6, GM-CSF, CXCL1, IFN-γ, IL-2, IL-8, CXCL11, CXCL9, CCL17, and CCL25 at T1; and higher levels of MIF and CCL23 at T2 than the patients who maintained normal LVEF. Patients with LVEF decline of 5–10% had lower plasma levels of CXCL1, CCL3, GDF-15, and haptoglobin at T0; lower levels of IL-16, FABP3, and myoglobin at T1; and lower levels of myoglobin and CCL23 at T2 as compared to the patients who maintained normal LVEF. This pilot study identified potential biomarkers that may help predict which patients are vulnerable to DOX-induced cardiotoxicity although further validation is needed in a larger cohort of patients. Impact statement Drug-induced cardiotoxicity is one of the major concerns in drug development and clinical practice. It is critical to detect potential cardiotoxicity early before onset of symptomatic cardiac dysfunction or heart failure. Currently there are no qualified clinical biomarkers for the prediction of cardiotoxicity caused by cancer treatment such as doxorubicin (DOX). By using multiplex immunoassays, we identified proteins with significantly changed plasma levels in a group of breast cancer patients who were treated with DOX-based chemotherapy and produced cardiotoxicity. These proteins were associated with immune response and were identified before DOX treatment or at early doses of treatment, thus they could be potential predictive biomarkers of cardiotoxicity although further validation is required to warrant their clinical values.
Uncovered Chimney Stent Graft for Renal Arteries With the Nellix Endovascular Aneurysm Sealing Technique
Authors: Garriboli Luca , Jannello Antonio Maria 
Published: December 2017

Purpose: To describe the application of uncovered chimney stent grafts with the Nellix endovascular aneurysm sealing technique (ChEVAS) for juxtarenal abdominal aortic aneurysms (JAAAs). Case Report: Two patients with JAAA and multiple comorbidities were considered unfit for open surgery and were selected for an endovascular approach. Fenestrated and branched endografts were too expensive, and a chimney endovascular approach was considered inappropriate for the relatively high incidence of proximal type I endoleak and graft migration. ChEVAS was performed successfully with the novel addition of uncovered chimney stents to further reduce costs and possibly improve target vessel patency. JAAA exclusion and visceral vessel patency was confirmed at 18-month follow-up. Conclusion: ChEVAS with bare chimney stents is technically less complex, potentially reduces access complications and procedural costs, and may improve long-term patency compared to alternative techniques. Results at 18 months seem promising, but strict follow-up is necessary as the long-term durability is unknown.
Expected Time to Return to Athletic Participation After Stress Fracture in Division I Collegiate Athletes
Authors: Miller Timothy L. , Jamieson Marissa , Everson Sonsecharae , Siegel Courtney 
Published: December 2017

Background: Few studies have documented expected time to return to athletic participation after stress fractures in elite athletes. Hypothesis: Time to return to athletic participation after stress fractures would vary by site and severity of stress fracture. Study Design: Retrospective cohort study. Level of Evidence: Level 3. Methods: All stress fractures diagnosed in a single Division I collegiate men’s and women’s track and field/cross-country team were recorded over a 3-year period. Site and severity of injury were graded based on Kaeding-Miller classification system for stress fractures. Time to return to full unrestricted athletic participation was recorded for each athlete and correlated with patient sex and site and severity grade of injury. Results: Fifty-seven stress fractures were diagnosed in 38 athletes (mean age, 20.48 years; range, 18-23 years). Ten athletes sustained recurrent or multiple stress fractures. Thirty-seven injuries occurred in women and 20 in men. Thirty-three stress fractures occurred in the tibia, 10 occurred in the second through fourth metatarsals, 3 occurred in the fifth metatarsal, 6 in the tarsal bones (2 navicular), 2 in the femur, and 5 in the pelvis. There were 31 grade II stress fractures, 11 grade III stress fractures, and 2 grade V stress fractures (in the same patient). Mean time to return to unrestricted sport participation was 12.9 ± 5.2 weeks (range, 6-27 weeks). No significant differences in time to return were noted based on injury location or whether stress fracture was grade II or III. Conclusion: The expected time to return to full unrestricted athletic participation after diagnosis of a stress fracture is 12 to 13 weeks for all injury sites. Clinical Relevance: Athletes with grade V (nonunion) stress fractures may require more time to return to sport.
Acute stress disorder and C-reactive protein in patients with acute myocardial infarction
Authors: Bielas Hannes , Meister-Langraf Rebecca E , Schmid Jean-Paul , Barth Jürgen , Znoj Hansjörg , Schnyder Ulrich , Princip Mary , von Känel Roland 
Published: December 2017

Background Myocardial infarction-triggered acute stress disorder (ASD) and subclinical inflammation associate with the development of posttraumatic stress disorder, and worsen the prognosis of myocardial infarction patients. We examined the relationship between ASD severity and C-reactive protein levels in patients with acute myocardial infarction. Methods We assessed 190 patients (median age 59 years; 83% men) with a verified myocardial infarction within 48 h of an acute coronary intervention. Circulating levels of C-reactive protein were categorized according to their prognostic risk for cardiovascular disease: 0 to <5, 5 to <10, 10 to <20, and ≥ 20 mg/l. Patients completed the ASD-Scale (ASDS) for myocardial infarction-triggered symptoms and questionnaires for demographic factors, health behaviours, cardiac-related variables and psychosocial characteristics. Results The ASDS sum score was positively associated with C-reactive protein categories in the bivariate analysis ( r = 0.20, p < 0.01). Significant relationships with C-reactive protein also emerged for dissociation ( r = 0.25, p < 0.001) and avoidance ( r = 0.19, p < 0.01), but not for arousal and re-experiencing. Similarly, C-reactive protein levels ≥ 20 mg/l versus < 20 mg/l were predicted by the ASDS sum score, and the dissociation, avoidance and arousal subscores (all p-values < 0.05) in the fully adjusted binary regression analyses. C-reactive protein levels ≥ 20 mg/l were also independently predicted by male gender, body mass index, lower education, and lower left ventricular ejection fraction and higher white blood cell count. Conclusions Higher levels of myocardial infarction-triggered ASD symptoms associate with a greater inflammatory response in patients with acute myocardial infarction independently of important covariates. The findings suggest a link between myocardial infarction-triggered ASD symptoms and a heightened acute phase response with a potential impact on cardiovascular disease prognosis.
Spontaneous cerebrospinal fluid leak from the optic canal
Authors: Hannabass Kyle , Justice Jeb M 
Published: December 2017

Objective: To present a case of successful repair of a spontaneous cerebrospinal fluid leak in a previously unreported anatomic site. Methods: Retrospective chart review. Results: A 48-year-old woman developed a spontaneous cerebrospinal fluid leak from the optic nerve sheath and underwent a multilayer endoscopic closure with no damage to the optic nerve. Conclusion: Endoscopic surgeons can successfully repair cerebrospinal fluid leaks from the optic nerve sheath without causing loss of vision.
Comprehensive home-based care coordination for vulnerable elders with dementia: Maximizing Independence at Home-Plus—Study protocol
Authors: Samus Quincy M , Davis Karen , Willink Amber , Black Betty S , Reuland Melissa , Leoutsakos Jeannie , Roth David L , Wolff Jennifer , Gitlin Laura N , Lyketsos Constantine G , Johnston Deirdre 
Published: December 2017

Introduction Despite availability of effective care strategies for dementia, most health care systems are not yet organized or equipped to provide comprehensive family-centered dementia care management. Maximizing Independence at Home-Plus is a promising new model of dementia care coordination being tested in the U.S. through a Health Care Innovation Award funded by the Centers for Medicare and Medicaid Services that may serve as a model to address these delivery gaps, improve outcomes, and lower costs. This report provides an overview of the Health Care Innovation Award aims, study design, and methodology. Methods This is a prospective, quasi-experimental intervention study of 342 community-living Medicare–Medicaid dual eligibles and Medicare-only beneficiaries with dementia in Maryland. Primary analyses will assess the impact of Maximizing Independence at Home-Plus on risk of nursing home long-term care placement, hospitalization, and health care expenditures (Medicare, Medicaid) at 12, 18 (primary end point), and 24 months, compared to a propensity-matched comparison group. Discussion The goals of the Maximizing Independence at Home-Plus model are to improve care coordination, ability to remain at home, and life quality for participants and caregivers, while reducing total costs of care for this vulnerable population. This Health Care Innovation Award project will provide timely information on the impact of Maximizing Independence at Home-Plus care coordination model on a variety of outcomes including effects on Medicaid and Medicare expenditures and service utilization. Participant characteristic data, cost savings, and program delivery costs will be analyzed to develop a risk-adjusted payment model to encourage sustainability and facilitate spread.
Care coordination in a business-to-business and a business-to-consumer model for telemonitoring patients with chronic diseases
Authors: Grustam Andrija S , Vrijhoef Hubertus , Cordella Antonio , Koymans Ron , Severens Johan L 
Published: December 2017

Introduction For telemonitoring to support care coordination, a sound business model is conditional. The aim of this study is to explore the systemic and economic differences in care coordination via business-to-business and business-to-consumer models for telemonitoring patients with chronic diseases. Methods We performed a literature search in order to design the business-to-business and business-to-consumer telemonitoring models, and to assess the design elements and themes by applying the activity system theory, and describe the transaction costs in each model. The design elements are content, structure, and governance, while the design themes are novelty, lock-in, complementarities, and efficiency. In the transaction cost analysis, we looked into all the elements of a transaction in both models. Results Care coordination in the business-to-business model is designed to be organized between the places of activity, rather than the participants in the activity. The design of the business-to-business model creates a firm lock-in but for a limited time. In the business-to-consumer model, the interdependencies are to be found between the persons in the care process and not between the places of care. The differences between the models were found in both the design elements and the design themes. Discussion Care coordination in the business-to-business and business-to-consumer models for telemonitoring chronic diseases differs in principle in terms of design elements and design themes. Based on the theoretical models, the transaction costs could potentially be lower in the business-to-consumer model than in the business-to-business, which could be a promoting economic principle for the implementation of telemonitoring.
Use of Visual Decision Aids in Physician–Patient Communication
Authors: Mercer Mary Beth , Rose Susannah L , Talerico Cassandra , Wells Brian J , Manne Mahesh , Vakharia Nirav , Jolly Stacey , Milinovich Alex , Bauman Janine , Kattan Michael W 
Published: December 2017

Introduction: A risk calculator paired with a personalized decision aid (RC&DA) may foster shared decision-making in primary care. We assessed the feasibility of using an RC&DA with patients in a primary care outpatient clinic and patients’ experiences regarding communication and decision-making. Methods: This pilot study was conducted with 15 patients of 3 primary care physicians at a clinic within a tertiary medical center. An atherosclerotic cardiovascular disease (ASCVD) risk calculator was used to generate a personalized RC&DA that displayed absolute 10-year risk information as an icon array graphic. Patient perceptions of utility of the RC&DA, preferences for decision-making, and uncertainty with risk reduction decisions were measured with a semi-structured interview. Results: Patients reported that the RC&DA was easy to understand and knowledge gained was useful to modify their ASCVD risk. Patients used the RC&DA to make decisions and reported low uncertainty with those decisions. Conclusions: Our findings demonstrate the feasibility of, and positive patient experiences related to using, an RC&DA to facilitate shared decision-making between physicians and patients in an outpatient primary care setting.
Sustainable aquaculture development in floating nets at Cirata reservoir (West Java, Indonesia) through single-sex nilem fish introduction
Authors: YUSTIATI AYI , ANDRIANI YULI , HERAWATI TITIN 
Published: December 2017

Yustiati A, Andriani Y, Herawati T. 2017. Sustainable aquaculture development in floating nets at Cirata reservoir (West Java, Indonesia) through single-sex nilem fish introduction. Asian J Agric 1: 29-34. This research aims to develop a sustainable aquaculture system using single-sex nilem fish in trophic level-based farming and to analyze the feeding habits, types of meal and preference level of the feed in nilem farmed in Cirata Reservoir. In addition, it also aims to determine the fish's ability as a biocontrol agent for water cleaning by measuring the ability to utilize periphyton attached to the floating nets. Research conducted at the Laboratory of Ciparanje, Faculty of Fisheries and Marine Sciences, Universitas Padjadjaran and floating nets of Cirata reservoir. Observation of the performance of biological testing and food feeding applies the experimental design method of Completely Randomized Design (CRD) consisting 5 treatments and 3 replications. The five treatments include non-artificial feeding (treatment A), 1% feeding of body weight per day (treatment B), 2% feeding of body weight per day (treatment C), 3% of feeding of body weight per day (treatment D), and 4% feeding of body weight per day (treatment E). The results showed there was no difference in the survival and growth levels of the female single-sex fish given both commercial and non-commercial feed. The highest feed efficiency was observed in the 3% of commercial feeding treatment, amounting to 55.30%. The fish are herbivorous and generalist with trophic levels between 1.03% and 1.45% eating planktons for living. Fish fed with artificial food to 4% of the biomass still graze on phytoplankton as the main source of food, but adapt by changing the natural feeding and tend to be ineffective in utilizing the available food resources in the waters. During the study, the types and amount of periphyton attached to the nets have decreased. Higher commercial feeding level results in the higher density of periphyton in the floating nets.
Non-timber forest products extracted activities of the upstream Mamberamo basinâ€™s traditional communities of West Papua, Indonesia
Authors: RAHAWARIN YOHANES Y. 
Published: December 2017

Rahawarin YY. 2017. Non-timber forest products extracted activities of the upstream Mamberamo basinâ€™s traditional communities of West Papua, Indonesia. Asian J For 1: 23-26. The aim of this study is to find utilization activities of extracting nontimber forest products by local communities on the upstream part of Mamberamo Basin. Survey, observation and semi-structural interview were taken to generate data and information. The result showed that the local communities extracted several of non-timber forest products over the course of their generations to fulfill basic daily necessities. There were several types of non-timber forest products that have been used by local communities either from plants wild animals that living across different types of forest. These activities were lasted for generations so that people called it as a traditional conservation. They are still exist recently and believed to maintain the long-lasting of non timber forest products continuity to keep the availability of traditional food sources for the daily needs over generations.
Theatre and democracy in the Athenian city state
Authors: Allern Tor-Helge 
Published: December 2017

Abstract
This article discusses the relationship between theatre and democracy in the Athenian city-state. The multivocal form of theatre and its dialogical character were essential to a functioning democracy. In tragedy, the dialogical and participatory aspect also involved the staging of ambivalence, linguistic ambiguities, the characters’ misunderstandings, their selfish hubris and fatal choices. Tragedy shows the democratic potential of theatre to open up the acknowledgement that no single voice or way of living is absolutely or completely true. Tragedy was also an option when it came to giving marginalized groups (women, youth, slaves and foreigners) a voice, and challenging hegemonic perspectives and traditional conceptions; however, I will also show how both these institutions fortified men’s dominance in society.
Drama, dissensus, remediation and a fluttering butterfly
Authors: Kusk Hanne 
Published: December 2017

Abstract
Why is it important to pay attention to democracy and polyphony when working with remediation in a multimodal drama project in introductory schooling? This question is elucidated and investigated in this article on the basis of a drama project case study conducted at Hundborg Friskole. The study is analysed on the basis of the concepts of remediation (Bolter and Grusin 1999; Christoffersen 2009), dissensus (Biesta 2013; Rancière 2013), dialogue and polyphony (Dysthe, Bernhardt and Esbjørn 2012). The examples in the investigation show how dialogue, polyphony and dissensus influence the art-based process of remediation, and how this impacts children’s democratic education.
The teacher as leader of democratic processes in the drama classroom
Authors: Vangsnes Vigdis , Økland Nils Tore Gram 
Published: December 2017

Abstract
This is a follow-up study to a previous large-scale qualitative study that explored teacher practice, in which it was suggested that the teacher’s role is best understood by considering three main categories of activities: the directing, the supportive and the distal teacher roles. These three are dynamic roles or positions among which the pedagogue continuously alternates to achieve the aims that foster learning and socialization in students. Based on new data from primary school classrooms, where the teaching method is process drama, we analyse how the teacher can stimulate democratic bildung in the drama classroom through alternation between the directing, the supportive and the distal teacher roles. A dramaturgical and educational analysis of the participants’ actions and communication in the classroom shows that one important factor in democratic bildung in the classroom is the teacher’s pedagogical judgement. The alternation between teacher roles shows that the teacher has a conscious perspective of their professional role in the learning process. The analysis also shows that process drama is a teaching strategy that provides space and opportunity for the directing, the supportive and the distal teacher roles – all of which, when practised dynamically, make possible different forms of democratic student participation.
Towards a new ‘we’: Applied theatre as integration
Authors: Bruun Ellen Foyn 
Published: December 2017

Abstract
This article presents the Norwegian applied theatre project called P:UNKT, which suggests a meeting point, a crossroads and encounters. The aim of the project was to stimulate integration and cultural diversity, with the outreach nature of P:UNKT resulting in new ways of interaction and collaboration across groups and institutions. I conducted research on the project from 2010 to 2012 and three years later, in 2016. I claim that the project enabled ethnic Norwegians and immigrants to create unique storytelling theatre together that transcended the conventional preconceptions of us and them, resulting in the emergence of a new ‘we’. This type of social and applied theatre run by a professional, state-funded theatre is not common in Norway. The findings of my research are therefore of relevance to local communities, theatre companies and politicians. The P:UNKT project is an example of the active role that applied theatre can play in shaping Norwegian identity construction in the twenty-first century.
Our Lady’s Folk: Creating authoritative aesthetic communication in documentary theatre
Authors: Aune Vigdis 
Published: December 2017

Abstract
In 2014 there was a constitutional anniversary in Norway. The documentary theatre Vår Frues Folk (Our Lady’s Folk) was based on a hypothesis that staged experiences by people who function and live on the margins of the welfare state serve as a critical contribution to the celebration of the constitution. The director is at the heart of any theatre production, and is therefore at risk of colonizing the material and reproducing the interviewees’ voices from their own perspectives and artistic interests. A major question was therefore how ownership and authority could unfold thematically and aesthetically in collaboration with the interviewees. The theatre project was inspired by Hannah Arendt’s thoughts about authority and about creating arenas where the potential for spontaneous actions, dialogue and aesthetic experiences can be linked to debate about democratic politics. This article explains and discusses how design-based artistic strategies safeguarded the ability to act as an authority, act with authority, and create authoritative, aesthetic communication in documentary theatre.