bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anything is better than nothing’: exploring attitudes towards novel therapies in leukodystrophy clinical trials
Authors: Wilson Ella , Leventer Richard , Cunningham Chloe , de Silva Michelle G. , Hodgson Jan , Uebergang Eloise 
Published: September 2024

Abstract
Background/Aim
Leukodystrophies comprise a group of genetic white matter disorders that lead to progressive motor and cognitive impairment. Recent development of novel therapies has led to an increase in clinical trials for leukodystrophies. To enable recruitment of individuals with a leukodystrophy into clinical trials, clinical trial acceptability should be ascertained. We sought therefore, to identify the motivations for and barriers to clinical trial participation in addition to clinical trial features that may be of concern to individuals with a leukodystrophy and/or their carers.

Methods
Adults with a leukodystrophy and parents/carers of individuals with a leukodystrophy were recruited through the Australian Leukodystrophy Registry and through online advertisements. Qualitative semi-structured interviews were used to explore participants views on what clinical trials involve, the perceived risks and benefits of clinical trials, their desire to participate in clinical trials and their personal experience with leukodystrophy. Thematic analysis of data was performed with co-coding of interview transcripts.

Results
5 interviews were held with parents of children with leukodystrophy, 4 with parents of adults with leukodystrophy and 3 with adults diagnosed with leukodystrophy. Motivations for clinical trial enrolment include access to potentially lifesaving novel treatments and improved prognostic outcomes. Participants were concerned about adverse clinical trial outcomes, including side effects and exacerbation of illness. Despite this, majority of participants were willing to try anything in clinical trials, demonstrating a high tolerance for first in human trials and trials utilising invasive treatment options.

Conclusions
Interviewees communicated a strong desire to participate in interventional clinical trials involving novel therapies. To support enrolment into future leukodystrophy clinical trials we suggest the provision of transparent information regarding clinical trial treatments, consideration of alternative trial control measures, and inclusion of treating clinicians in the trial recruitment process. Clinicians play an integral role in initiating transparent conversations regarding trial risks and adverse outcomes.
Epithelial cell-cell interactions in an overcrowded environment: jamming or live cell extrusion
Authors: Pajic-Lijakovic Ivana , Milivojevic Milan , McClintock Peter V. E. 
Published: September 2024

AbstractEpithelial tissues respond strongly to the mechanical stress caused by collective cell migration and are able to regulate it, which is important for biological processes such as morphogenesis, wound healing, and suppression of the spread of cancer. Compressive, tensional, and shear stress components are produced in cells when epithelial monolayers on substrate matrices are actively or passively wetted or de-wetted. Increased compressive stress on cells leads to enhanced cell-cell interactions by increasing the frequency of change the cell-cell distances, triggering various signalling pathways within the cells. This can ultimately lead either to cell jamming or to the extrusion of live cells. Despite extensive research in this field, it remains unclear how cells decide whether to jam, or to extrude a cell or cells, and how cells can reduce the compressive mechanical stress. Live cell extrusion from the overcrowded regions of the monolayers is associated with the presence of topological defects of cell alignment, induced by an interplay between the cell compressive and shear stress components. These topological defects stimulate cell re-alignment, as a part of the cells’ tendency to re-establish an ordered trend of cell migration, by intensifying the glancing interactions in overcrowded regions. In addition to individual cell extrusion, collective cell extrusion has also been documented during monolayer active de-wetting, depending on the cell type, matrix stiffness, and boundary conditions. Cell jamming has been discussed in the context of the cells’ contact inhibition of locomotion caused by cell head-on interactions. Since cell-cell interactions play a crucial role in cell rearrangement in an overcrowded environment, this review is focused on physical aspects of these interactions in order to stimulate further biological research in the field.
3D printed versus milled stabilization splints for the management of bruxism and temporomandibular disorders: study protocol for a randomized prospective single-blinded crossover trial
Authors: Rabel Kerstin , Lüchtenborg Jörg , Linke Marie , Burkhardt Felix , Roesner Anuschka J. , Nold Julian , Vach Kirstin , Witkowski Siegbert , Hillebrecht Anna-Lena , Spies Benedikt C. 
Published: September 2024

Abstract
Background
Nowadays, stabilization splints for the management of bruxism and temporomandibular disorders (TMD) can be produced utilizing a digital workflow comprising a digital impression of the teeth, digital splint design, and computer-aided manufacturing of the splints. The latter is usually a milling process, however, more recently 3D printing gained popularity due to its better cost and time efficiency. It remains unknown whether 3D printed stabilization splints are inferior to milled splints regarding clinical outcomes.

Methods
This clinical trial assesses the non-inferiority of 3D printed occlusal splints compared to milled occlusal splints in a monocentric prospective randomized single-blinded crossover trial with two cohorts. One cohort includes 20 participants with bruxism, the other 20 participants with pain-related TMD, i.e., myalgia, myofascial pain, or arthralgia of the jaw muscles/the temporomandibular joint(s) diagnosed according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Michigan-type stabilization splints are fabricated in a digital workflow by milling or 3D printing using CE-marked materials within their intended purpose. The participants wear a milled and a 3D printed splint in a randomized order for 3 months each, with follow-up visits after 2 weeks and 3 months. Investigated outcome parameters are oral health-related quality of life (OHRQoL) evaluated by the Oral Health Impact Profile (OHIP-G14), participant satisfaction as rated on a visual analog scale, therapeutic efficacy, and technical result of the splints. In this context, therapeutic efficacy means antagonist wear and—in the TMD group—reduction of pain/disability assessed by the Graded Chronic Pain Scale (GCPS v2.0) and clinical assessment following the DC/TMD standard, while technical outcome measures splint fit, wear and fracture rate.

Discussion
The trial will provide important information on the clinical outcome of 3D printed stabilization splints in comparison to milled splints and will, therefore, enable an evidence-based decision in favor of or against a manufacturing process. This, in turn, will guarantee for a maximum of the patient’s OHRQoL during splint therapy, therapeutic efficacy, and longevity of the splints.

Trial registration
German Clinical Trials Register (DRKS) DRKS00033904. Registered on March 15, 2024.
Incidence of symptomatic Borrelia burgdorferi sensu lato infection in Romania, 2018−2023
Authors: Angulo Frederick J. , Olsen Julia , Purdel Veronica , Lupșe Mihaela , Hristea Adriana , Briciu Violeta , Colby Emily , Pilz Andreas , Halsby Kate , Kelly Patrick H. , Brestrich Gordon , Moïsi Jennifer C. , Stark James H. 
Published: September 2024

Abstract
Background
Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl), is the most common tick-borne disease in Europe. Although public health surveillance for LB has been conducted in Romania since 2007, the extent of under-detection of Bbsl infections by LB surveillance has not been estimated. We therefore estimated the under-detection of symptomatic Bbsl infections by LB surveillance to better understand the LB burden in Romania.

Methods
The number of incident symptomatic Bbsl infections were estimated from a seroprevalence study conducted in six counties (population 2.3 M) and estimates of the symptomatic proportion and duration of persistence of anti-Bbsl immunoglobulin G (IgG) antibodies. The number of incident symptomatic Bbsl infections were compared with the number of surveillance-reported LB cases to derive an under-detection multiplier, and then the under-detection multiplier was applied to LB surveillance data to estimate the incidence of symptomatic Bbsl infection from 2018 to 2023.

Results
We estimate that there were 1968 individuals with incident symptomatic Bbsl infection in the six counties where the seroprevalence study was conducted in 2020, compared with the 187 surveillance-reported LB cases, resulting in an under-detection multiplier of 10.5 (i.e., for every surveillance-reported LB case, there were 10.5 symptomatic incident Bbsl infections). The incidence of symptomatic Bbsl infection in the six counties was 86.9/100,000 population in 2023, similar to the incidence in 2018−2020 (86.0) and higher than in 2021−2022 (40.3).

Conclusions
There is a higher incidence of symptomatic Bbsl infection than is reported through public health surveillance for LB in Romania. Additional efforts are needed to strengthen disease prevention and address the important public health problem of LB.

Graphic Abstract
A potential biomarker for age-related macular degeneration disease: iris freckles
Authors: Koc Hakan , Uzunoğlu Seda 
Published: September 2024

Abstract
Backgraund
To determine the potential relationship between age-related macular degeneration and iris freckles.

Method
In this case-control study, iris photographs of 300 eyes of 300 patients diagnosed with age-related macular degeneration and 300 eyes of 300 healthy volunteers were obtained with the help of a high-resolution mobile phone camera. The evaluated iris photographs were classified according to the Descriptive Iris Color Classification Scale.

Results
The average age of the AMD group is 73.05 ± 6.93, and the average age of the control group is 73.43 ± 5.72. (p = 0.124) While freckles were present in 200 (66.7%) of the patients in the AMD group, freckles were not observed in 100 patients (33.3%) of AMD group. While freckles were present in 142 (47.3%) of the patients in the control group, freckles were not observed in 158 of control group(52.7%). There was a significant difference in the presence of freckles between the two groups. (p < 0.001) The average number of freckles in the AMD group was 3.97 ± 3.07, and the number of freckles in the control group was 3.06 ± 2.55. (p = 0.001)

Conclusion
We think that evaluation of iris details, especially the presence of iris freckles, should be used routinely in age-related macular degeneration screening. The risk of age-related macular degeneration can be predicted by evaluating iris details, which is an easy and inexpensive method.
A mixed-method randomised controlled feasibility trial of digital CBT and emotion regulation skills training for employees in the workplace (REST)
Authors: Moukhtarian T. R. , Fletcher S. , Walasek L. , Kershaw C. , Patel K. , Hurley-Wallace A. L. , Russell S. , Daly G. , Tang N. K. Y. , Toro C. T. , Meyer C. 
Published: September 2024

Abstract
Background and aim
Digital interventions for depression and anxiety can be as effective as face-to-face therapy. One in six workers experience some form of mental health problems, making the workplace a potential avenue to deliver mental health interventions as part of a stepped care model. This study aimed to assess the acceptability, feasibility, and preliminary efficacy of a digital cognitive behavioural therapy (dCBT) on depression and anxiety for employees in the workplace.

Methods
A mixed-methods evaluation of employees allocated to dCBT (n=25), or a waitlist control group (n=27) was used to assess five feasibility objectives related to recruitment of employers and employees, engagement, study procedure and preliminary efficacy of the intervention. Quantitative outcome measures and qualitative interviews at 8 weeks post-randomisation were used. Quantitative outcomes were also assessed within subject at 3-, 6-, and 12-month follow-up. Qualitative data was analysed using thematic and framework analysis in Nvivo, whilst quantitative outcomes were analysed using mixed effect linear models between and within subject in R and SPSS.

Results
Thirty-Three businesses agreed to facilitate the delivery of three trials run by the University of Warwick in their workplaces. 52 participants consented into the REST trial. Adherence/usage of participants of the treatment platform was just over 50% across the whole sample. There was a reduction in depression and anxiety symptoms post-intervention and at follow-up timepoints across all participants and over time although there were no statistically significant between group differences. High acceptability and satisfaction of the intervention were reported by participants based on qualitative interview data at post-intervention.

Conclusions
Results from this feasibility study suggests that the dCBT programme (REST) was acceptable and shows improvement in depression and anxiety symptoms, albeit not over and above the treatment effects in the control group. Recruitment of participants and engagement with the intervention made the feasibility of the delivery somewhat challenging. With better recruitment promotion and engagement strategies, as well as implementing the learnings from the feasibility trial, a fully powered study can inform the efficacy of the REST intervention.

Trial registration
The study is registered in the BMC Springer Nature ISRCTN registry ISRCTN31161020 (registered on 08/06/2021).
Potential of E-Learning Interventions and Artificial Intelligence–Assisted Contouring Skills in Radiotherapy: The ELAISA Study
Authors: Rasmussen Mathis Ersted , Akbarov Kamal , Titovich Egor , Nijkamp Jasper Albertus , Van Elmpt Wouter , Primdahl Hanne , Lassen Pernille , Cacicedo Jon , Cordero-Mendez Lisbeth , Uddin A.F.M. Kamal , Mohamed Ahmed , Prajogi Ben , Brohet Kartika Erida , Nyongesa Catherine , Lomidze Darejan , Prasiko Gisupnikha , Ferraris Gustavo , Mahmood Humera , Stojkovski Igor , Isayev Isa , Mohamad Issa , Shirley Leivon , Kochbati Lotfi , Eftodiev Ludmila , Piatkevich Maksim , Bonilla Jara Maria Matilde , Spahiu Orges , Aralbayev Rakhat , Zakirova Raushan , Subramaniam Sandya , Kibudde Solomon , Tsegmed Uranchimeg , Korreman Stine Sofia , Eriksen Jesper Grau 
Published: September 2024

PURPOSE Most research on artificial intelligence–based auto-contouring as template (AI-assisted contouring) for organs-at-risk (OARs) stem from high-income countries. The effect and safety are, however, likely to depend on local factors. This study aimed to investigate the effects of AI-assisted contouring and teaching on contouring time and contour quality among radiation oncologists (ROs) working in low- and middle-income countries (LMICs). MATERIALS AND METHODS Ninety-seven ROs were randomly assigned to either manual or AI-assisted contouring of eight OARs for two head-and-neck cancer cases with an in-between teaching session on contouring guidelines. Thereby, the effect of teaching (yes/no) and AI-assisted contouring (yes/no) was quantified. Second, ROs completed short-term and long-term follow-up cases all using AI assistance. Contour quality was quantified with Dice Similarity Coefficient (DSC) between ROs' contours and expert consensus contours. Groups were compared using absolute differences in medians with 95% CIs. RESULTS AI-assisted contouring without previous teaching increased absolute DSC for optic nerve (by 0.05 [0.01; 0.10]), oral cavity (0.10 [0.06; 0.13]), parotid (0.07 [0.05; 0.12]), spinal cord (0.04 [0.01; 0.06]), and mandible (0.02 [0.01; 0.03]). Contouring time decreased for brain stem (–1.41 [–2.44; –0.25]), mandible (–6.60 [–8.09; –3.35]), optic nerve (–0.19 [–0.47; –0.02]), parotid (–1.80 [–2.66; –0.32]), and thyroid (–1.03 [–2.18; –0.05]). Without AI-assisted contouring, teaching increased DSC for oral cavity (0.05 [0.01; 0.09]) and thyroid (0.04 [0.02; 0.07]), and contouring time increased for mandible (2.36 [–0.51; 5.14]), oral cavity (1.42 [–0.08; 4.14]), and thyroid (1.60 [–0.04; 2.22]). CONCLUSION The study suggested that AI-assisted contouring is safe and beneficial to ROs working in LMICs. Prospective clinical trials on AI-assisted contouring should, however, be conducted upon clinical implementation to confirm the effects.
Long-term Metabolic Dysfunction Programming in Female Mice by Serial Moderate Restriction of a High-fat High-sucrose Diet
Authors: Wildes Micah P , Fernando Deemantha G , Grobe Connie C , Reho John J , Grobe Justin L , Kidambi Srividya , Kindel Tammy L , Kwitek Anne E , Segar Jeffrey L , Williams Joni S , Morselli Lisa L 
Published: September 2024

Abstract

Background
While intermittent fasting leads to weight loss and improved glucose metabolism, food insecurity, the insufficient access to food for a healthy life, is associated with obesity and adverse cardiometabolic health, especially in women. We aimed to characterize the effects of intermittently restricted feeding on energy balance and glucose tolerance in female mice.

Methods
Female C57BL/6J mice were fed a high-fat, high-sucrose diet and intermittently food restricted to 60% of control littermates’ ad libitum intake, starting at weaning and until week 19. Restricted mice were subsequently allowed ad libitum access to the same diet. Body composition and energy balance were measured at weeks 18.5, 19, 30, and 40. At week 42, mice underwent an intraperitoneal glucose tolerance test and plasma appetitive hormones measurements after nutrient gavage.

Results
During the food restriction phase, restricted mice accrued lower weight and fat mass than controls despite periodic ad libitum food access. Reintroduction of continuous ad libitum food caused increased food intake during the light phase and increased body mass in restricted mice. Minor differences in body composition-adjusted energy expenditure between groups were observed at week 40. At week 42, glucose tolerance was impaired in restricted mice compared to controls, and trends toward lower levels of postprandial anorexigenic hormones glucagon-like peptide-1 and pancreatic polypeptide were observed.

Conclusion
Our findings suggest that repeated intermittent food restriction leads to changes in eating behavior that predispose to glucose intolerance when food is freely available. Future studies are needed to elucidate the specific mechanisms underlying these changes.
Hyperoxia disproportionally benefits the aerobic performance of large fish at elevated temperature
Authors: Kuchenmüller Luis L. , Hoots Elizabeth C. , Clark Timothy D. 
Published: September 2024

ABSTRACT
Increasing evidence shows that larger fish are more vulnerable to acute warming than smaller individuals of the same species. This size-dependency of thermal tolerance has been ascribed to differences in aerobic performance, largely owing to a decline in oxygen supply relative to demand. To shed light on these ideas, we examined metabolic allometry in 130 rainbow trout ranging from 12 to 358 g under control conditions (17°C) and in response to acute heating (to 25°C), with and without supplemental oxygen (100% versus 150% air saturation). Under normoxia, high temperature caused an average 17% reduction in aerobic scope compared with 17°C. Aerobic performance disproportionally deteriorated in bigger fish as the scaling exponent (b) for aerobic scope declined from b=0.87 at 17°C to b=0.74 at 25°C. Hyperoxia increased maximum metabolic rate and aerobic scope at both temperatures and disproportionally benefited larger fish at 25°C as the scaling exponent for aerobic scope was reestablished to the same level as at 17°C (b=0.86). This suggests that hyperoxia may provide metabolic refuge for larger individuals, allowing them to sustain aerobic activities when facing acute warming. Notably, the elevated aerobic capacity afforded by hyperoxia did not appear to improve thermal resilience, as mortality in 25°C hyperoxia (13.8%, n=4) was similar to that in normoxia (12.1%, n=4), although we caution that this topic warrants more targeted research. We highlight the need for mechanistic investigations of the oxygen transport system to determine the consequences of differential metabolic scaling across temperature in a climate warming context.
Επανεξετάζοντας τις εικόνες του τέμπλου από τον ναό της Μεταμόρφωσης στη Βελτσίστα (Κληματιά) Ιωαννίνων
Authors: ΔΗΜΗΤΡΑΚΟΠΟΥΛΟΥ (Polykseni DIMITRAKOPOULOU) Πολυξένη 
Published: September 2024

Οι εικόνες από το τέμπλο του ναού της Μεταμόρφωσης στη Βελτσίστα (σημ. Κληματιά) Ιωαννίνων, έχουν ήδη συνδεθεί με την Κρητική σχολή. Με βάση, ωστόσο, εικονογραφικές και τεχνοτροπικές ομοιότητες ανάμεσα στις δεσποτικές εικόνες, τα βημόθυρα και τον ζωγραφικό διάκοσμο του ναού, και μετά από τις τελευταίες εργασίες συντήρησης που πραγματοποιήθηκαν σε ηπειρωτικά τοιχογραφικά σύνολα, θεωρούμε ότι οι ζωγράφοι των εικόνων αυτών κατάγονταν από την Ήπειρο και πιθανόν είχαν επαφές με το εργαστήρι των αδελφών Κονταρή. Η Δέηση και τα αποστολικά μπορούν να αποδοθούν σε ζωγράφους από την Κρήτη, οι οποίοι είχαν επηρεαστεί από την τέχνη των σημαντικών εκπροσώπων της κρητικής ζωγραφικής, την περίοδο της ακμής της.
Κλήμης Ασλανίδης, Βυζαντινή ναοδομία στη Νάξο. Η μετεξέλιξη από την παλαιοχριστιανική στη μεσοβυζαντινή αρχιτεκτονική
Authors: ΑΘΑΝΑΣΟΥΛΗΣ (Dimitris Athanasoulis) Δημήτρης 
Published: September 2024

Κλήμης Ασλανίδης, Βυζαντινή ναοδομία στη Νάξο. Η μετεξέλιξη από την παλαιοχριστιανική στη μεσοβυζαντινή αρχιτεκτονική, Κέντρο Βυζαντινών Ερευνών – Βυζαντινά Μνημεία 17, Θεσσαλονίκη 2017, 629 σελ., 99 σχέδ. και 124 πίν. με ασπρόμαυρες φωτογραφίες στο τέλος κάθε λήμματος μνημείου. Αγγλική περίληψη: Klimis Aslanidis, “The evolution from Early-Christian to Middle-Byzantine church architecture on the island of Naxos”, σ. 571-584. Βιβλιογραφία (σ. 585-613). Ευρετήριο (615-629), 28×21 εκ. ISBN: 978-960-7856-56-2.
Alessandro Taddei, Hagia Sophia before Hagia Sophia. A study of the Great Church of Constantinople from its origins to the Nika Revolt of 532
Authors: ΧΑΤΖΗΛΑΖΑΡΟΥ (Dimitris Th. CHATZILAZAROU) Δημήτρης Θ. 
Published: September 2024

Alessandro Taddei, Hagia Sophia before Hagia Sophia. A study of the Great Church of Constantinople from its origins to the Nika Revolt of 532 (Saggi di storia dell’arte, 52), Campisano Editore, Ρώμη 2017, 310 σελ., 157 εικ., 15,50×21,50 εκ. ISBN: 978-88-85795-00-6.
Mirosłav Piotr Kruk (ed.), Icons from the 14th-16th Centuries in the National Museum in Krakow, Volume IMirosłav Piotr Kruk (ed.), Icons from the 14th-16th Centuries in the National Museum in Krakow, Volume I, Catalogue (in Polish and English),, Catalogue (in Polish and English),
Authors: Δρακοπούλου (Eugenia DRAKOPOULOU) Ευγενία 
Published: September 2024

Mirosłav Piotr Kruk (ed.), Icons from the 14th-16th Centuries in the National Museum in Krakow, Volume I, Catalogue (in Polish and English), The National Museum in Krakow, 2019, 759 pp., ISBN: 978-83-7581-293-7. Volume II, Technological Tests (in Polish and English), The National Museum in Krakow,2019, 343 pp., ISBN: 978-83-7581-295-4. Volume III, Illustrations (in Polish and English), The National Museum in Krakow, 2019, 611 pp., ISBN: 978-83-7581-293-1