bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of volatile components and identification of the most potent odour‐active component in fermented meat sauce
Authors: Ohata Motoko , Zhou Lanxi , Higuchi Kaori , Nagai Tsugumi , Kasamatsu Hiroko , Arihara Keizo 
Published: April 2017

AbstractThe present study investigated the volatile constituents of fermented meat sauce (FMS) and identified some of the potent odour‐active components. The FMS was prepared by fermenting a mixture of ground pork, koji, and salt for 12 months. After 12 months' fermentation, four potent odour components: 3‐hydroxy‐4,5‐dimethyl‐2(5H)‐furanone (sotolon), 4‐hydroxy‐2(or 5)‐ethyl‐5(or 2)‐methyl‐3(2H)‐furanone (ethyl furaneol), 4‐hydroxy‐2,5‐dimethyl‐3(2H)‐furanone, and 3‐methylbutanoic acid, were found in FMS by gas chromatography‐olfactometry analysis. The most characteristic components were sotolon and ethyl furaneol and contributed strongly to the FMS odour. These two components were detected in the FMS after 6 and 9 months' fermentation, respectively; especially sotolon concentration was 147.43 mg/l after 12 months' fermentation. These components were generated by fermentation and might play an important role in the FMS odour after 12 months' fermentation.
An HPLC method for the detection of hydro peroxides derived from linalyl acetate in citrus oils, using post‐column luminol‐mediated chemiluminescence detection
Authors: Calandra Michael J. , Wang Ying 
Published: April 2017

AbstractLinalyl acetate is an unsaturated terpene commonly found in many essential oils, and it is easily oxidized by atmospheric oxygen to form hydroperoxides. The hydroperoxides of linalyl acetate are known to be sensitizers capable of causing allergic contact dermatitis. The standard iodometric titration methods (peroxide value [POV] methods) typically used to measure hydroperoxide levels in essential oils provide only a total level of all oxidizing species, including hydroperoxides. These POV methods are not capable of species differentiation and therefore may not reliably correlate well with the dermatological sensitizing potency of a particular sample. This laboratory has previously reported a high‐performance liquid chromatographic method using a post‐column chemiluminescent reaction to detect hydroperoxides derived from limonene and linalool. Herein we report that this same method is also useful for the detection of hydroperoxides derived from linalyl acetate.
Valuing productivity costs using the friction‐cost approach: Estimating friction‐period estimates by occupational classifications for the UK
Authors: Kigozi Jesse , Jowett Sue , Lewis Martyn , Barton Pelham , Coast Joanna 
Published: April 2017

AbstractThe friction cost approach has been proposed as an alternative to the human capital approach in estimating productivity costs. However, it is difficult, in practice, to apply this approach due to limited availability of context‐specific data. Using national and firm‐level data on vacancy durations sourced from 4 organisations, we estimated vacancy durations, and consequently, length of friction period for the United Kingdom disaggregated by occupational classification. We found comparable estimates to previously reported friction periods elsewhere. The disaggregated friction period analysis confirmed occupational class has an effect on the estimated length of the friction period. The research presents estimates on vacancy durations and friction periods necessary to use the friction cost approach in a practical way in economic evaluations.
Ventral, but not dorsal, hippocampus inactivation impairs reward memory expression and retrieval in contexts defined by proximal cues
Authors: Riaz Sadia , Schumacher Anett , Sivagurunathan Seyon , Van Der Meer Matthijs , Ito Rutsuko 
Published: April 2017

AbstractThe hippocampus (HPC) has been widely implicated in the contextual control of appetitive and aversive conditioning. However, whole hippocampal lesions do not invariably impair all forms of contextual processing, as in the case of complex biconditional context discrimination, leading to contention over the exact nature of the contribution of the HPC in contextual processing. Moreover, the increasingly well‐established functional dissociation between the dorsal (dHPC) and ventral (vHPC) subregions of the HPC has been largely overlooked in the existing literature on hippocampal‐based contextual memory processing in appetitively motivated tasks. Thus, the present study sought to investigate the individual roles of the dHPC and the vHPC in contextual biconditional discrimination (CBD) performance and memory retrieval. To this end, we examined the effects of transient post‐acquisition pharmacological inactivation (using a combination of GABAA and GABAB receptor agonists muscimol and baclofen) of functionally distinct subregions of the HPC (CA1/CA3 subfields of the dHPC and vHPC) on CBD memory retrieval. Additional behavioral assays including novelty preference, light‐dark box and locomotor activity test were also performed to confirm that the respective sites of inactivation were functionally silent. We observed robust deficits in CBD performance and memory retrieval following inactivation of the vHPC, but not the dHPC. Our data provides novel insight into the differential roles of the ventral and dorsal HPC in reward contextual processing, under conditions in which the context is defined by proximal cues.
The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation
Authors: Bermeo Sandra , Al‐Saedi Ahmed , Kassem Moustapha , Vidal Christopher , Duque Gustavo 
Published: April 2017

ABSTRACTMutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism of this pro‐osteogenic phenotype remains unknown. We increased and decreased MAN1 expression in mesenchymal stem cells (MSC) upon which standard osteogenic and adipogenic differentiation were performed. MAN1 knockdown increased osteogenesis and mineralization. In contrast, osteogenesis remained stable upon MAN1 overexpression. Regarding a mechanism, we found that low levels of MAN1 facilitated the nuclear accumulation of regulatory smads and smads‐related complexes, with a concurrently high expression of nuclear β‐Catenin. In addition, we found adipogenesis to be decreased in both conditions, although predominantly affected by MAN1 overexpression. Finally, lamin A, a protein of the nuclear envelope that regulates MSC differentiation, was unaffected by changes in MAN1. In conclusion, our studies demonstrated that lower levels of MAN1 in differentiating MSC are associated with higher osteogenesis and lower adipogenesis. High levels of MAN1 only affected adipogenesis. These effects could have an important role in the understanding of the role of the proteins of the nuclear envelope in bone formation. J. Cell. Biochem. 118: 4425–4435, 2017. © 2017 Wiley Periodicals, Inc.
The influence of different muscle mass measurements on the diagnosis of cancer cachexia
Authors: Blauwhoff‐Buskermolen Susanne , Langius Jacqueline A.E. , Becker Annemarie , Verheul Henk M.W. , de van der Schueren Marian A.E. 
Published: April 2017

AbstractBackgroundProgressive loss of muscle mass is a major characteristic of cancer cachexia. Consensus definitions for cachexia provide different options to measure muscle mass. This study describes the effect of different methods to determine muscle mass on the diagnosis of cancer cachexia. In addition, the association of cachexia with other features of cachexia, quality of life, and survival was explored.MethodsPrior to chemotherapy, cachexia was assessed by weight loss, body mass index, and muscle mass measurements, the latter by mid‐upper arm muscle area (MUAMA), computed tomography (CT) scans, and bio‐electrical impedance analysis (BIA). In addition, appetite, inflammation, muscle strength, fatigue, quality of life, and survival were measured, and associations with cachexia were explored.ResultsIncluded were 241 patients with advanced cancer of the lung (36%), colon/rectum (31%), prostate (18%), or breast (15%). Mean age was 64 ± 10 years; 54% was male. Prevalence of low muscle mass was as follows: 13% with MUAMA, 59% with CT, and 93% with BIA. In turn, the prevalence of cachexia was 37, 43, and 48%, whereby weight loss >5% was the most prominent component of being defined cachectic. Irrespective of type of muscle measurement, patients with cachexia presented more often with anorexia, inflammation, low muscle strength, and fatigue and had lower quality of life. Patients with cachexia had worse overall survival compared with patients without cachexia: HRs 2.00 (1.42–2.83) with MUAMA, 1.64 (1.15–2.34) with CT, and 1.50 (1.05–2.14) with BIA.ConclusionsAlthough the prevalence of low muscle mass in patients with cancer depended largely on the type of muscle measurement, this had little influence on the diagnosis of cancer cachexia (as the majority of patients was already defined cachectic based on weight loss). New studies are warranted to further elucidate the additional role of muscle measurements in the diagnosis of cachexia and the association with clinical outcomes.
Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+/calmodulin‐dependent kinase II
Authors: Seeger Christian , Talibov Vladimir O. , Danielson U. Helena 
Published: April 2017

AbstractCalmodulin (CaM) functions depend on interactions with CaM‐binding proteins, regulated by
. Induced structural changes influence the affinity, kinetics, and specificities of the interactions. The dynamics of CaM interactions with neurogranin (Ng) and the CaM‐binding region of
/calmodulin‐dependent kinase II (CaMKII290−309) have been studied using biophysical methods. These proteins have opposite
dependencies for CaM binding. Surface plasmon resonance biosensor analysis confirmed that
and CaM interact very rapidly, and with moderate affinity (
). Calmodulin‐CaMKII290−309 interactions were only detected in the presence of
, exhibiting fast kinetics and nanomolar affinity (
). The CaM–Ng interaction had higher affinity under
‐depleted (
and k−1 = 1.6 × 10−1s−1) than
‐saturated conditions (
). The IQ motif of Ng (Ng27−50) had similar affinity for CaM as Ng under
‐saturated conditions (
), but no interaction was seen under
‐depleted conditions. Microscale thermophoresis using fluorescently labeled CaM confirmed the surface plasmon resonance results qualitatively, but estimated lower affinities for the Ng (
) and CaMKII290−309(
) interactions. Although CaMKII290−309 showed expected interaction characteristics, they may be different for full‐length CaMKII. The data for full‐length Ng, but not Ng27−50, agree with the current model on Ng regulation of
/CaM signaling.
Characterization of tunable graphene metasurfaces over an ultrawide terahertz band using a 1‐step leapfrog hybrid implicit‐explicit FDTD method
Authors: Zhai Meng‐Lin , Peng Hong‐Li , Li De‐Min , Wang Da‐Wei , Xie Hao , Yin Wen‐Yan 
Published: April 2017

AbstractAn improved 1‐step leapfrog hybrid implicit‐explicit finite‐difference time domain method is developed for simulating tunable characteristics of graphene metasurfaces over an ultrawide terahertz band for different physical and geometrical parameters. The graphene conductivity is described by a closed‐form approximate expression and further expanded into a rational sum of complex‐conjugate pole‐residue pairs using the vector‐fitting technique. It is further implemented into the leapfrog hybrid implicit‐explicit finite‐difference time domain by an associated auxiliary differential equation formulation. Parametric studies are performed for capturing terahertz band responses of some typical graphene metasurfaces, with their tunabilities investigated and compared for different chemical potentials, layer numbers of graphene surface, operating temperatures, etc. When the results are compared with conventional finite‐difference time domain and analytical solutions, the proposed method demonstrates both high efficiency and good accuracy.
Synoptic climatology of lake‐effect snowfall conditions in the eastern Great Lakes region
Authors: Suriano Zachary J. , Leathers Daniel J. 
Published: April 2017

ABSTRACTThe characteristics of overlying synoptic conditions play an important role in the production of lake‐effect snowfall within the Great Lakes region of North America. With a synoptic climatological approach, the synoptic‐scale patterns conducive to lake‐effect snowfall are identified for the eastern Great Lakes region during the November–March seasons of 1950–2009. Seven synoptic types identified as lake effect are combined with daily snowfall observations to examine the role of individual synoptic types on seasonal snowfall. The types exhibit a wide range of surface and 850 hPa temperatures and winds, sea‐level pressures, snowfall intensities, and inter‐annual frequencies. These factors result in substantial differences in the location and magnitude of seasonal lake‐effect snowfall.Recent research has revealed that snowfall within portions of the Great Lakes region subject to lake‐effect snow has undergone a trend reversal, declining in recent decades. Examining the inter‐annual frequency of the seven lake‐effect synoptic types, a majority of types increased in frequency prior to 1980, before becoming less frequent thereafter. The variability in frequency of lake‐effect synoptic types can partially be explained by relationships to large‐scale atmospheric and oceanic modes of variability. The majority of lake‐effect synoptic types occur in association with an upper‐level trough over the eastern United States. This trough is consistent with the upper‐level pattern associated with a negative phase Arctic Oscillation (AO) and North Atlantic Oscillation (NAO), or positive Pacific/North American pattern (PNA), such that when the AO, NAO, and/or PNA pattern are in those respective phases, there is a significant increase in the frequency of lake‐effect synoptic types.
Short‐term treatments with high CO2 and low O2 concentrations on quality of fresh goji berries (Lycium barbarum L.) during cold storage
Authors: Kafkaletou Mina , Christopoulos Miltiadis V , Tsantili Eleni 
Published: April 2017

AbstractBACKGROUNDGoji berries (Lycium barbarum L.) are functional fruits but are usually marketed as a dried product. The aim of this study was to investigate the storability of fresh goji berries treated with high CO2 and low O2 concentrations before air storage at 1 °C for 21 days.RESULTSBerries harvested without stems were exposed to air (controls) or subjected for 2 days at 1 °C to the following controlled atmosphere (CA) treatments: 21% O2 + 0% CO2 (21+0), 5% O2 + 15% CO2 (5+15), 10% O2 + 10% CO2 (10+10) and 20% O2 + 20% CO2 (20+20). During 14 days of storage, all treatments decreased weight loss, while treatments 5+15 and 20+20 prevented fungal decay. No fermentation was observed. The treatments did not affect color changes, decreases in soluble sugars and increases in total soluble solids, titratable acidity, ascorbic acid, total carotenoids, total phenolics and ferric‐reducing antioxidant power (FRAP) during storage, apart from the marginally reduced FRAP by treatment 20+20 on day 7. Treatments 5+15, 10+10 and 20+20 resulted in residual decreases in respiration rates and pH values early during storage. After 14 days of storage, panelists rated the CA‐treated samples as sweet, with good acceptance.CONCLUSIONTreatments 5+15 and 20+20 showed the best results after 14 days of storage. © 2017 Society of Chemical Industry
Duty‐Related Trauma Exposure and Posttraumatic Stress Symptoms in Professional Firefighters
Authors: Lee Junghyun H. , Lee Dayoung , Kim Jiae , Jeon Kyoungsun , Sim Minyoung 
Published: April 2017

Firefighters commonly encounter traumatic events during duty hours. The purpose of this study was to investigate the characteristics of duty‐related trauma as risk factors for posttraumatic stress disorder in professional firefighters. A sample of 212 firefighters participated in the study and completed self‐reported questionnaires. Potentially traumatic events (PTE) were assessed using a list of 17 traumatic event types. The posttraumatic stress symptoms (PTSS) were measured by the Impact of Event Scale‐Revised (Lim et al., 2009; Weiss, 2007). A higher score for the composite index, which reflects both multiple PTE and peritraumatic suffering, increased the odds for significant PTSS after adjusting for age, sex, marital status, education, numbers of years worked, childhood trauma, and depressive symptoms (adjusted odds ratio [AOR] = 2.26, p = .001, Cohen's d = 0.20). Furthermore, indirect (AOR = 1.93, p = .009, Cohen's d = .16) and colleague‐related PTE (AOR = 1.97, p = .037, Cohen's d = .16) showed significant associations with PTSS. It is noteworthy that the combination of multiple PTE and peritraumatic suffering was more predictive of PTSS than either factor alone. Our findings also suggest that daily work exposure to indirect PTE may contribute to the occurrence of PTSS among professional firefighters.
Iterative model and trajectory refinement for orbital trajectory optimization
Authors: Hudson Jennifer , Gupta Rohit , Li Nan , Kolmanovsky Ilya 
Published: April 2017

SummaryAn iterative model and trajectory refinement (IMTR) strategy is proposed for trajectory optimization of nonlinear systems. A high‐ and a low‐fidelity models are used. The high‐fidelity model accurately represents the system but is not easily amenable to trajectory optimization, because of degree of nonlinearity, computational cost, or to being of “black‐box” type. The low‐fidelity model is suitable for numerical optimization but approximates the system dynamics with an error. The IMTR method is proposed to systematically iterate between the 2 models and efficiently converge on a control solution. Examples are drawn from orbital mechanics. The IMTR approach is compared to optimal nonlinear quadratic control using Pontryagin maximum principle. A convergence criterion for the IMTR iterations is established.
Safety profile of medication used during pregnancy: results of a multinational European study
Authors: Trønnes Johanne N. , Lupattelli Angela , Nordeng Hedvig 
Published: April 2017

AbstractPurposeThe present study describes the safety profile of medications used during pregnancy across European countries and examines maternal factors associated with the use of risky medications during pregnancy.MethodsThis study is based on a multinational, web‐based study conducted in 15 European countries from October 2011 to February 2012. Information about maternal demographics, illnesses, and medication use during pregnancy was collected via an electronic questionnaire. Pregnant women and new mothers with a child less than 1‐year‐old could participate. The Swedish, Australian, and U.S. risk classification systems were used to evaluate medication safety. Descriptive statistics and generalized estimating equation models were used.ResultsA total of 587 medications were reported by the study sample (n = 6657). Sixty‐nine percent of the women used medications classified as safe, 28% used medications classified as risky, and 3% used medications with no classification available. Both socio‐demographic and medical factors were associated with the use of risky medications during pregnancy. Having a chronic disorder was the factor with the strongest association with the use of risky medications during pregnancy (adjusted odds ratio = 3.99, 95% confidence interval 3.54–4.49).ConclusionsThe majority of women used medications classified as safe to use during pregnancy. However, a considerable proportion of women still used medications classified as risky. Having a chronic disorder was an important driver for using risky medications. Such use may still be appropriate when considering the woman's underlying condition. Pre‐pregnancy counselling is important to ensure safe medication use for both mother and child. © 2017 The Authors. Pharmacoepidemiology & Drug Safety Published by John Wiley & Sons Ltd.
Silencing of Agrobacterium tumefaciens oncogenes ipt and iaaM induces resistance to crown gall disease in plum but not in apricot
Authors: Alburquerque Nuria , Faize Lydia , Burgos Lorenzo 
Published: April 2017

AbstractBACKGROUNDIn this study, two vectors with short‐length chimeric transgenes were used to produce Prunus rootstocks resistant to crown gall disease through RNA‐interference‐mediated gene silencing of the Agrobacterium tumefaciens oncogenes ipt and iaaM.RESULTSTransgenic plum and apricot lines were produced with efficiencies of up to 7.7 and 1.1% respectively. An in vitro evaluation method allowed identification of susceptible lines and reduction in the number of lines to be evaluated in the greenhouse. Five transgenic plum lines, expressing transgene‐derived small interfering RNA (siRNA) and low levels of transgene hairpin RNA (hpRNA), showed a significant reduction in the development of the disease after infection with Agrobacterium strains C58 and A281 under greenhouse conditions. However, unexpectedly, all transgenic apricot lines were gall susceptible. The infection of apricot plants with a binary vector containing only the 6b oncogene demonstrated that the expression of this gene is involved in the induction of tumours in the apricot species.CONCLUSIONRNAi‐mediated gene silencing can be used for inducing crown gall resistance in plum rootstocks. These could be used to graft non‐genetically modified commercial fruit cultivars reducing, or eliminating, the disease symptoms. © 2017 Society of Chemical Industry
Area‐wide mass trapping by pheromone‐based attractants for the control of sugar beet weevil (Bothynoderes punctiventris Germar, Coleoptera: Curculionidae)
Authors: Drmić Zrinka , Tóth Miklós , Lemić Darija , Grubišić Dinka , Pospišil Milan , Bažok Renata 
Published: April 2017

AbstractBACKGROUNDOwing to the changing climate, narrow crop rotation, and changes in insecticide application practice, sugar beet weevil (SBW) (Bothynoderes punctiventris Germar) has become the most important economic pest in sugar beet. To develop alternative control methods, an area‐wide (AW) control program using aggregation pheromones was implemented over 4 years on an area of 6 and 14.8 km2 in east Croatia.RESULTSThe mass trapping of SBW on the ‘old’ sugar beet fields reduced the population from 0.73% to 11.59%. Owing to the strong attack, mass trapping was not effective enough to avoid an insecticide application. However, it significantly reduced the number of insecticide applications, the amount of insecticide used, and the damage compared to the fields outside the mass trapping area.CONCLUSIONThis is the first study to implement an AW program for SBW. It may not be possible to state from this study that trapping alone can reduce the SBW population below the economic threshold level. However, the data do suggest that trapping can play an important role in the reduction of insecticide applications and in creating an integrated pest management plan for dealing with SBW under similar circumstances. © 2017 Society of Chemical Industry
Electrochemical Hydrazine Oxidation Catalyzed by Iron Phosphide Nanosheets Array toward Energy‐Efficient Electrolytic Hydrogen Production from Water
Authors: Zhang Ling , Liu Danni , Hao Shuai , Xie Lisi , Qu Fengli , Du Gu , Asiri Abdullah M. , Sun Xuping 
Published: April 2017

AbstractIt is highly needed but still a difficult challenge to achieve energy‐saving electrolytic hydrogen generation. In this communication, we describe the first use of iron phosphide nanosheets array on Ni foam as a high‐active and durable catalyst for electrochemical hydrazine oxidation reaction (HzOR) in alkaline media. The high hydrogen‐evolving activity of this catalyst electrode and the substitution of sluggish oxygen evolution with thermodynamically more favorable HzOR enables the construction of a stable two‐electrode energy‐efficient electrolytic hydrogen generation system capable of driving 125 mA cm−2 at a cell voltage of 0.5 V to in 1.0 M KOH with 0.5 M hydrazine.