bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of polymer dispersed liquid crystal doped with bilayer nanofiber membranes and phase‐change microcapsule coating for enhanced infrared modulation
Authors: Zhong Zhenlei , Zhao Yuzhen , Li Xun , He Zemin , Gao Hong , Guo Zhun , Wang Dong , Wang Lei , Luan Yi 
Published: August 2024

AbstractThe effective manipulation and regulation of infrared (IR) radiation represent significant advancements in the realm of liquid crystal applications. In this investigation, the synergistic integration of nanofiber membranes and phase change microencapsulated film with polymer dispersed liquid crystal (PDLC) layers was employed for IR modulation. To obtain the excellent electro‐optical properties of PDLC composite films, the ratio of the PDLC system, the thickness of the nanofiber membrane, and the concentration of phase‐change microcapsules were meticulously regulated, and the polymer network morphology of the PDLC films was analyzed to achieve a high contrast ratio (162.72) of PDLC composite films. The fabricated PDLC composite devices show excellent IR shielding efficiency of 15% in the presence of doped nanofiber membranes and phase change microencapsulated films. Notably, patterned nanofiber layers and phase‐change microcapsule coating were obtained by template electrospinning, resulting in patternable PDLC composite film devices.
Efficient Deep‐Blue Fluorescent OLEDs Based on a D–π–A Emitter Profiting From Intramolecular Hydrogen Bonds and a Hybridized Excited State
Authors: Ji Ying , Ma Chenglin , Qiu Xu , Liu Xinyong , Li Jingwei , Zhou Jiadong , Xue Shanfeng 
Published: August 2024

AbstractHigh performance deep‐blue emitters with a Commission International de l'Eclairage (CIE) coordinate of CIEy≤0.08 are highly desired in ultrahigh‐definition displays. Herein, we designed and synthesized an efficient D–π–A deep‐blue emitter, 2‐(6‐([1,1′ : 3′,1′′‐terphenyl]‐5′‐yl)pyridin‐3‐yl)‐1‐phenyl‐1H‐phenanthro[9,10‐d] imidazole (mPTPH), using the synergistic effect of intramolecular hydrogen bond (H‐bond) and hybridized excited state. Single‐crystal structure analysis confirmed that there exist intra‐ and intermolecular H‐bond interactions which could inhibit the structure vibration and increase photoluminescence efficiency. The photophysical and theoretical results show that mPTPH exhibited hybridized local and charge‐transfer (HLCT) feature with strong deep‐blue emission. Ultimately, the non‐doped device based on mPTPH exhibited high maximum luminance of 20610 cd m−2. The doped device achieved high maximum external quantum efficiency of 5.4 % and small efficiency roll‐off with deep‐blue emission peak of 413 nm and CIE coordinate of (0.16, 0.08).
Sleep and health improvement programme (SHIP) for patients with prostate cancer and caregivers
Authors: Loeb Stacy , Robbins Rebecca , Sanchez‐Nolasco Tatiana , Byrne Nataliya , Ruan Andrea , Rivera Adrian , Gupta Natasha , Kenfield Stacey A. , Chan June M. , Van Blarigan Erin L. , Carter Patricia , Jean‐Louis Girardin , Orstad Stephanie L. 
Published: August 2024

AbstractObjectiveThe objective of this study is to determine whether a sleep and health improvement programme (SHIP) to promote healthy sleep, eating and physical activity would be feasible, acceptable and have a positive impact on lifestyle behaviours for prostate cancer survivors and caregivers.MethodsWe recruited 50 participants for a single group 3‐month pre‐post pilot study. The SHIP intervention included (1) website about sleep, nutrition and physical activity (≥1 view/week), (2) two email newsletters with goal‐setting exercises and resources and (3) midpoint health coach call. The primary outcome was changes in validated sleep scales; secondary outcomes included changes in diet, physical activity and concentration from baseline to 3 months.ResultsOf 50 participants enrolled, median age was 65, 30% were Black and 8% were Hispanic. Thirty‐four patients and 7 family caregivers completed the pilot study (82%). Following the intervention, we observed a statistically significant improvement in the Sleep Hygiene Index (pre: 15, post: 13, p < 0.01), and a trend toward lower Insomnia Severity Index (pre: 12, post: 9, p = 0.07). There were no statistically significant improvements in sleep quality or physical activity, but there were improvements in healthy eating (e.g., increase in cruciferous vegetables and reduction in dairy) and in fatigue‐related problems and concentration. Exit interview feedback was positive.ConclusionsA web‐based sleep and healthy lifestyle programme for patients with prostate cancer and their caregivers is feasible and acceptable. A randomized controlled trial is planned to test whether a refined SHIP improves sleep and lifestyle in patients with prostate cancer and caregivers.
Climate Change and Congenital Anomalies: A Population‐Based Study of the Effect of Prolonged Extreme Heat Exposure on the Risk of Neural Tube Defects in France
Authors: Bruckner Tim A. , Trinh Nhung T. H. , Lelong Nathalie , Madani Kaveh , Slama Rémy , Given Joanne , Khoshnood Babak 
Published: August 2024

ABSTRACTBackgroundExposure to long‐lasting extreme ambient temperatures in the periconceptional or early pregnancy period might increase the risk of neural tube defects (NTDs). We tested whether prolonged severe heat exposure as experienced during the 2003 extreme heatwave in France, affected the risk of NTDs.MethodsWe retrieved NTD cases spanning from January 1994 to December 2018 from the Paris Registry of Congenital Malformations. The 2003 heatwave was characterized by the long duration and high intensity of nine consecutive days with temperatures ≥35°C. We classified monthly conceptions occurring in August 2003 as “exposed” to prolonged extreme heat around conception (i.e., periconceptional period). We assessed whether the risk of NTDs among cohorts exposed to the prolonged severe heatwave of 2003 in the periconceptional period differed from expected values using Poisson/negative binomial regression.FindingsWe identified 1272 NTD cases from January 1994 to December 2018, yielding a monthly mean count of 4.24. Ten NTD cases occurred among births conceived in August 2003. The risk of NTD was increased in the cohort with periconceptional exposure to the August 2003 heatwave (relative risk = 2.14, 95% confidence interval: 1.46 to 3.13), compared to non‐exposed cohorts. Sensitivity analyses excluding July and September months or restricting to summer months yielded consistent findings.InterpretationEvidence from the “natural experiment” of an extreme climate event suggests an elevated risk of NTDs following exposure to prolonged extreme heat during the periconceptional period.
Formate Salt as a Bifunctional Reagent for Hydroxylation and Carbonylation Reactions Under Photochemically Driven Nickel Catalysis
Authors: Yang Yi , Su Junping , Guerin Timothe , Nielsen Martin , Tlili Anis 
Published: August 2024

AbstractIn this study, we disclose for the first time that formate salt can be used as a bifunctional reagent for the synthesis of phenol derivatives and as a CO source for carbonylative cross‐coupling processes using the COware gas reactor under activation free conditions. Key to this success is the in‐situ synthesis of aryl formate via an unprecedented nickel/organophotocatalyst system under blue LED irradiation. This developed system demonstrated high applicability to various aryl iodide substrates for synthesizing phenol derivatives. Moreover, the generated CO could be utilized in a range of carbonylative C‐heteroatom and C−C processes. Notably, commercially available H13COONa salt can serve as a bifunctional reagent for both synthesizing phenols and generating 13CO.
Predictors of mortality by an artificial intelligence enhanced electrocardiogram model for cardiac amyloidosis
Authors: Amadio Jennifer M. , Grogan Martha , Muchtar Eli , Lopez‐Jimenez Francisco , Attia Zachi I. , AbouEzzeddine Omar , Lin Grace , Dasari Surendra , Kapa Suraj , Borgeson Daniel D. , Friedman Paul A. , Gertz Morie A. , Murphree Dennis H. , Dispenzieri Angela 
Published: August 2024

AbstractAimsWe aim to determine if our previously validated, diagnostic artificial intelligence (AI) electrocardiogram (ECG) model is prognostic for survival among patients with cardiac amyloidosis (CA).MethodsA total of 2533 patients with CA (1834 with light chain amyloidosis (AL), 530 with wild‐type transthyretin amyloid protein (ATTRwt) and 169 with hereditary transthyretin amyloid (ATTRv)] were included. An amyloid AI ECG (A2E) score was calculated for each patient reflecting the likelihood of CA. CA stage was calculated using the European modification of the Mayo 2004 criteria for AL and Mayo stage for transthyretin amyloid (ATTR). Risk of death was modelled using Cox proportional hazards, and Kaplan–Meier was used to estimate survival.ResultsMedian age of the cohort was 67 [inter‐quartile ratio (IQR) 59, 74], and 71.6% were male. The median overall survival for the cohort was 35.6 months [95% confidence interval (CI) 32.3, 39.5]. For AL, ATTRwt and ATTRv, respectively, median survival was 22.9 (95% CI 19.2, 28.2), 47.2 (95% CI 43.4, 52.3) and 61.4 (95% CI 48.7, 75.9) months. On univariate analysis, an increasing A2E score was associated with more than a two‐fold risk of all‐cause death. On multivariable analysis, the A2E score retained its importance with a risk ratio of 2.0 (95% CI 1.58, 2.55) in the AL group and 2.7 (95% CI 1.81, 4.24) in the ATTR group.ConclusionsAmong patients with AL and ATTR amyloidosis, the A2E model helps to stratify risk of CA and adds another dimension of prognostication.
Explorative sensory profile evaluation in central neuropathic pain following spinal cord injury
Authors: Landmann G. , Ernst M. , Opsommer E. , Stockinger L. , Vollert J. , Baron R. 
Published: August 2024

AbstractBackgroundSensory profiling in neuropathic pain using quantitative sensory testing (QST) has not been extended to central neuropathic pain due to spinal cord injury (SCI). This study aims to fill this gap by evaluating sensory profiles in patients with neuropathic SCI pain.MethodWe retrospectively analysed consecutive QST data from 62 patients with neuropathic spinal cord injury pain (SCIP), following the German Research Network on Neuropathic Pain protocol. The study included at‐level and below‐level SCIP due to a spinal cord lesion, and at‐level SCIP following a cauda equina lesion. QST parameters were compared between diagnostic groups. QST profiles of below‐level SCIP (central neuropathic pain) were manually assigned to sensory phenotypes based on literature and expert opinion.ResultsNo statistical difference in QST parameters between pain diagnoses was found. For central neuropathic pain (below‐level SCIP), three phenotypes were descriptively observed: loss of function (59%), thermal and mechanical hyperalgesia combination (16%), and mechanical hyperalgesia (19%). The remaining 5% of patients did not fit a common pattern. There was no statistical difference in clinical and psychological variables between phenotypes. In a subgroup analysis, the loss of function phenotype weakly correlated with older age, longer time since injury, and longer pain duration.ConclusionsHere, we capture sensory phenotypes of central neuropathic pain following SCI. The limited sample size, high rate of missing values, and the retrospective nature of the study mean that results should be seen as strictly exploratory. Further research should replicate these findings and explore the significance of phenotypes.Significance statementThe evaluation of sensory phenotypes by quantitative sensory testing in central neuropathic pain due to SCI adds a new perspective on sensory phenotypes in comparison to peripheral neuropathic pain. The described thermal and mechanical hyperalgesia combination might represent involvement of the spinothalamic tract. In addition, there was a trend towards older age and longer time since injury in patients with loss of function.
Next‐generation sequencing in pediatric‐onset epilepsies: Analysis with target panels and personalized therapeutic approach
Authors: Castellotti Barbara , Ragona Francesca , Freri Elena , Messina Giuliana , Magri Stefania , Previtali Roberto , Solazzi Roberta , Franceschetti Silvana , Taroni Franco , Canafoglia Laura , Gellera Cinzia , Granata Tiziana , DiFrancesco Jacopo C. 
Published: August 2024

AbstractObjectiveThe objective of this study is to report the results of the genetic analysis in a large and well‐characterized population with pediatric‐onset epilepsies and to identify those who could benefit from precision medicine treatments.MethodsIn this retrospective observational study, we consecutively recruited patients with pediatric‐onset epilepsy observed at a tertiary neurological center over a time span of 7 years, collecting clinical and laboratory findings. Following in‐depth diagnostic process to exclude possible structural and metabolic causes of the disease, patients with a suspected genetically determined etiology underwent next‐generation sequencing (NGS) screening with panels for the analysis of target genes causative of epilepsy.ResultsWe detected likely pathogenic or pathogenic variants (classes IV and V) in 24% of the 562 patients who underwent genetic investigations. By the evaluation of patients' data, we observed that some features (onset of epilepsy before one year old, presence of neurological deficits, psychomotor delay/cognitive disability, and malformative aspects at brain MRI) were significantly associated with class IV or V variants. Moreover, statistical analysis showed that the diagnostic yield resulted higher for patients affected by Progressive Myoclonic Epilepsy (PME) and with early onset developmental and epileptic encephalopathies (DEE), compared with focal epilepsies, genetic generalized epilepsies, DEE with onset at/after 1 y.o., and unclassified epileptic syndromes. According to the results of the genetic screening, up to 33% of patients carrying class IV or V variants resulted potentially eligible for precision medicine treatments.SignificanceThe large‐scale application of NGS multigene panels of analysis is a useful tool for the molecular diagnosis of patients with pediatric‐onset epilepsies, allowing the identification of those who could benefit from a personalized therapeutic approach.Plain Language SummaryThe analysis of patients with pediatric‐onset epilepsy using advanced technologies for the screening of all the implicated genes allows the identification of the cause of diseases in an ever‐increasing number of cases. Understanding the pathogenic mechanisms could, in some cases, guide the selection and optimization of appropriate treatment approaches for patients.
Unveiling the antibacterial efficacy of thiazolo [3,2‐a] pyrimidine: Synthesis, molecular docking, and molecular dynamic simulation
Authors: Patel Vishant C. , Patel Ankit J. , Patel Darshan S. , Dholakia Amit B. , Ansari Siddique Akber , Agrawal Mohit 
Published: August 2024

AbstractTwo series of C‐Mannich base derivatives were synthesized and evaluated through the reaction of formaldehyde, two thiazolo‐pyrimidine compounds, and various 2°‐amines. The chemical structures and inherent properties of the synthesized compounds were authenticated using a variety of spectroscopic techniques. The aseptic bactericidal potential of the compounds was assessed alongside five common bacterial microbes, with Ampicillin employed as the reference drug. Compounds 9b and 9d demonstrated comparable antibacterial activity to ampicillin against Bacillus subtilis and Bacillus megaterium, respectively, at 100 μg/mL. Furthermore, compounds 9f and 10f exhibited noteworthy action against Staphylococcus aureus (MIC: 250 μg/mL). Compounds 10b and 10f displayed excellent efficacy versus Escherichia coli, boasting (MIC: 50 μg/mL). Molecular docking studies elucidated the necessary connections and energies of molecular entities with the E. coli DNA gyrase B enzyme, a pivotal target in bacterial DNA replication. Further thermodynamic stability of the ligand‐receptor complex of 10b and 10f were further validated though 200 ns molecular dynamics simulation. The findings highlight the potential of these synthesized derivatives as effective antibacterial agents and provide valuable insights into their mechanism of action.
Melatonin alleviates arsenic‐induced liver injury by regulating protein RKIP and enhancing antioxidant defencse mechanisms
Authors: Rezvankhah Soheil , Zargari Felor , Sharifi Rasoul 
Published: August 2024

AbstractArsenic (As) is a highly toxic metal and one of the main factors in cancer development through oxidative stress and production of reactive oxygen species. Prior research has demonstrated melatonin's potential as a free radical scavenger. Raf kinase inhibitory protein (RKIP) is an important regulator of intracellular signaling pathways that has been linked to various types of cancer. The aim of this research was to explore the influence of melatonin's antioxidant properties on the expression of the protein RKIP and the antioxidant status of liver tissue in rats that were exposed to arsenic. Thirty two male Wistar rats were divided into four groups of eight, including control, melatonin‐treated (20 mg/Kg of melatonin), sodium arsenite‐treated (5.5 mg/Kg of sodium arsenite), and melatonin + sodium arsenite‐treated groups (combination) for 4 weeks. The expression level of protein RKIP was measured by Western blot, and malondialdehyde (MDA) content of the liver as well as the activities of antioxidant enzymes were measured. The data analyzed using one‐way ANOVA (significance level of p < 0.05) and GraphPad Prism (9) software. Sodium arsenite treatment led to a significant decrease in RKIP protein expression and antioxidant enzyme activity, and an increase in liver MDA levels (p < 0.001). Conversely, melatonin treatment in the combination group resulted in a significant increase in RKIP protein expression and antioxidant enzyme activity and a decrease in liver MDA levels (p < 0.05). These findings suggest that melatonin can attenuate oxidative damage caused by arsenic in liver cells by enhancing RKIP protein expression and antioxidant enzyme activity.
Microbial biofertilizers and algae‐based biostimulant affect fruit yield characteristics of organic processing tomato
Authors: Quintarelli Valentina , Borgatti Daniele , Baretta Mattia , Stazi Silvia Rita , Allevato Enrica , Pancaldi Simonetta , Baldisserotto Costanza , Mancinelli Roberto , Tedeschi Paola , Radicetti Emanuele , Ben Hassine Mortadha 
Published: August 2024

AbstractBACKGROUNDMicrobial biofertilizers and algae‐based biostimulants have been recognized for supporting sustainable agriculture. Field experiments were conducted in 2022 and 2023 growing seasons in an organic farm located in Ferrara (Italy) with the aim of evaluating plant growth‐promoting microorganisms (PGPMs) and algae‐based biostimulants (Biost) in tomato (Solanum lycopersicum L.). The experimental treatments were: (i) two microbial biofertilizers (PGPM_1, PGPM_2) and no inoculated plants (No_PGPM); and (ii) two algae‐based biostimulant rates (0.5% (Biost_0.5%), 1.0% (Biost_1.0%)) and no application (No_Biost). PGPMs were applied at transplanting, while biostimulants at 15 and 30 days after transplanting. Treatments were replicated three times according to a split‐plot experimental design. Plant characteristics were evaluated at 30 days after transplanting in No_Biost treatments. During tomato cultivation, soil plant analysis development (SPAD), nitrogen difference vegetation index (NDVI), leaf area index (LAI) and photosynthetic photon flux density (PPFD) were monitored. Tomato yield was determined.RESULTSPGPM_2 showed the highest shoot biomass (132.9 g plant−1), plant height (44.7 cm), leaf number (34.0 plant−1) and root biomass (9.22 g plant−1). Intermediate values were observed in PGPM_1, while all parameters were lower in No_PGPM. Both PGPMs achieved higher values of SPAD, NDVI, PPFD and LAI than No_PGPM. Biost_1.0% increased all measured growth parameters followed by Biost_0.5% and No_Biost, respectively. Tomato yield was the highest for PGPM_2–Biost_1.0% (67.2 t ha−1). PGPMs affected fruit size and sugar content, while biostimulants were associated with color and lycopene.CONCLUSIONThe application of microbial biofertilizers and algae‐based biostimulants could be part of environment‐friendly practice in organic farming. © 2024 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Varying patterns of taxonomic and functional plant composition and diversity across different types of urban and rural grasslands
Authors: Swacha Grzegorz , Raduła Małgorzata W. , Jewticz Sabina , Kusak Barbara , Świerszcz Sebastian 
Published: August 2024

AbstractSemi‐natural grasslands are found predominantly in agricultural landscapes; however, their counterparts are also found in cities, referred to as urban grasslands. We sampled the most extensive patches of urban grasslands in Wrocław (Poland, Europe) in urban parks and along a river valley. We compared urban grasslands to broadly defined rural grasslands in terms of compositional gradients and both taxonomic and functional diversity. We also tested for relationships between rare species and different facets of diversity. Urban grasslands corresponded to three rural grassland habitat types: mesic pastures, mesic meadows, and alluvial meadows. We conducted analogous analyses, including and excluding habitat‐level assignment, to determine if emerging patterns between rural and urban grasslands are habitat‐dependent. Rural pastures and their urban counterparts showed high taxonomic and functional similarity, implying that short‐ and frequent‐cutting, applied in cities, mimics grazing management on agricultural sites. Rural mesic hay grasslands and alluvial meadows showed high taxonomic and functional dissimilarities from their urban counterparts. We found that rare species contribute to taxonomic diversity while only affecting functional diversity in a few cases. Varying patterns of taxonomic and functional similarity were observed across different habitats. Comparisons of grasslands without regard for habitat types mask diverging patterns in taxonomic and functional diversity. Despite high environmental and management pressures in urban areas (higher nutrient levels and temperatures, decreased moisture, and intensified management and soil disturbances), we showed that urban grasslands hold a considerable portion of the plant diversity found in rural grasslands.