bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fears and joys of writing in the fiction of Roberto Bolaño
Authors: González Aníbal 
Published: September 2024

Abstract
Roberto Bolaño’s achievement is to have written “literature about literature” that nevertheless feels profoundly alive, immediate, and exciting. This literature recognizes the intimidating and ethically dubious aspects of fiction writing, and of writing as a whole, while also imbuing its storytelling with feelings of energy and exultation. This article discusses Bolaño’s novel Distant Star and his other works, including the novel Amuleto. Drawing upon a framework of religion, secularism, and postsecularism, this article shows how Bolaño follows an ethics of writing which turns the fear of writing into a joyful and liberating activity.
A Deployable Viscoelastic Coagulation Monitor Enables Point-of-Care Assessment of Coagulopathy in Swine With Polytrauma
Authors: Roberts Teryn R , Garcia Isabella , Slychko Ivan , Dalton Heidi J , Batchinsky Andriy I 
Published: September 2024

ABSTRACT

Introduction
Absence of pre-hospital coagulation tests challenges prompt management of hemostasis after trauma. The Viscoelastic Coagulation Monitor (VCM, Entegrion, Durham, NC) is a hand-held coagulation test for point-of-care. We evaluated VCM in a translational swine polytrauma model, hypothesizing that VCM correlates with a laboratory reference method, the TEG 5000 (Haemonetics, Boston, MA), and can identify coagulopathic phenotypes relevant to trauma. Our secondary hypothesis was that pre-warming of VCM disposable test cartridges using a heating plate versus pre-warming of cartridges by carrying the cartridge in the user’s pocket does not significantly alter results.

Materials and Methods
This study was conducted in tandem with a parent study involving anesthetized, mechanically ventilated swine (n = 20; 54 ± 5 kg) that encountered traumatic brain injury, pulmonary contusion and hemorrhage, or combination/polytrauma injury. Blood was collected at baseline, post-injury, post-shock, post-transfusion, and 6-, 24-, and 48 h post-injury to perform VCM at point-of-care. Within-group effect of time was assessed. Spearman correlation examined linear relations between VCM and standard laboratory-based coagulation tests; as well as lactate, ionized calcium, and body temperature. Logistic regression examined predictiveness of VCM to identify coagulopathic phenotypes, with receiver operator characteristic curves generated to assess diagnostic capability. At a subset of timepoints, necessity of pre-warming the VCM test cartridge using a heating plate versus pre-warming the cartridge by placement in the user’s pocket was assessed by conducting simultaneous tests on two separate instruments, with results analyzed by paired t-test with crossover design.

Results
VCM revealed time-dependent changes in clotting time, clot formation time (CFT), alpha, maximum clot firmness (MCF), and lysis index (LI30). All VCM metrics correlated with the respective TEG 5000 metrics, with strongest correlation for VCM MCF with TEG MA (rhos = 0.77, P &lt; .0001) and VCM LI30 with TEG LY30 (rhos = −0.76, P &lt; .0001). VCM demonstrated good (area under the curve &gt;0.70) to excellent (area under the curve &gt;0.90) diagnostic accuracy in detection of low platelet count (MCF), low hematocrit (clotting time, clot formation time, alpha, and MCF), low fibrinogen (MCF), and high fibrinogen (alpha, MCF). There was no statistically or clinically relevant effect of cartridge warming method on results.

Conclusions
In a trauma model, VCM detected significant changes in coagulation at point-of-care in a simplified portable form factor. VCM could enable informed hemostasis management in pre-hospital settings where coagulations tests are unavailable, pending further validation in clinical trials.
Early galaxies and early dark energy: a unified solution to the hubble tension and puzzles of massive bright galaxies revealed by JWST
Authors: Shen Xuejian , Vogelsberger Mark , Boylan-Kolchin Michael , Tacchella Sandro , Naidu Rohan P 
Published: September 2024

ABSTRACT
JWST has revealed a large population of UV-bright galaxies at $z\gtrsim 10$ and possibly overly massive galaxies at $z\gtrsim 7$, challenging standard galaxy formation models in the ΛCDM cosmology. We use an empirical galaxy formation model to explore the potential of alleviating these tensions through an Early Dark Energy (EDE) model, originally proposed to solve the Hubble tension. Our benchmark model demonstrates excellent agreement with the UV luminosity functions (UVLFs) at $4\lesssim z \lesssim 10$ in both ΛCDM and EDE cosmologies. In the EDE cosmology, the UVLF measurements at $z\simeq 12$ based on spectroscopically confirmed galaxies (eight galaxies at $z\simeq 11\!-\!13.5$) exhibit no tension with the benchmark model. Photometric constraints at $12 \lesssim z\lesssim 16$ can be fully explained within EDE via either moderately increased star-formation efficiencies ($\epsilon _{\ast}\sim 3\!-\!10\ \hbox{per cent}$ at $M_{\rm halo}\sim 10^{10.5}{\, \rm M_\odot }$) or enhanced UV variabilities ($\sigma _{\rm UV}\sim 0.8\!-\!1.3$ mag at $M_{\rm halo}\sim 10^{10.5}{\, \rm M_\odot }$) that are within the scatter of hydrodynamical simulation predictions. A similar agreement is difficult to achieve in $\Lambda$CDM, especially at $z\gtrsim 14$, where the required $\sigma _{\rm UV}$ exceeds the maximum value seen in simulations. Furthermore, the implausibly large cosmic stellar mass densities inferred from some JWST observations are no longer in tension with cosmology when the EDE is considered. Our findings highlight EDE as an intriguing unified solution to a fundamental problem in cosmology and the recent tensions raised by JWST observations. Data at the highest redshifts reached by JWST will be crucial for differentiating modified galaxy formation physics from new cosmological physics.
The JWST EXCELS survey: too much, too young, too fast? Ultra-massive quiescent galaxies at 3 &lt; z &lt; 5
Authors: Carnall A C , Cullen F , McLure R J , McLeod D J , Begley R , Donnan C T , Dunlop J S , Shapley A E , Rowlands K , Almaini O , Arellano-Córdova K Z , Barrufet L , Cimatti A , Ellis R S , Grogin N A , Hamadouche M L , Illingworth G D , Koekemoer A M , Leung H -H , Lovell C C , Pérez-González P G , Santini P , Stanton T M , Wild V 
Published: September 2024

ABSTRACT
We report ultra-deep, medium-resolution spectroscopic observations for four quiescent galaxies with log$_{10}(M_*/\mathrm{M_\odot })\gt 11$ at $3 \lt z \lt 5$. These data were obtained with JWST NIRSpec as part of the Early eXtragalactic Continuum and Emission Line Science (EXCELS) survey, which we introduce in this work. The first two galaxies are newly selected from PRIMER UDS imaging, both at $z=4.62$ and separated by 860 pkpc on the sky, within a larger structure for which we confirm several other members. Both formed at $z\simeq 8-10$. These systems could plausibly merge by the present day to produce a local massive elliptical galaxy. The other two ultra-massive quiescent galaxies are previously known at $z=3.99$ and 3.19, with the latter (ZF-UDS-7329) having been the subject of debate as potentially too old and too massive to be accommodated by the $\Lambda$-CDM halo-mass function. Both exhibit high stellar metallicities, and for ZF-UDS-7329 we are able to measure the $\alpha -$enhancement, obtaining [Mg/Fe] = $0.42^{+0.19}_{-0.17}$. We finally evaluate whether these four galaxies are consistent with the $\Lambda$-CDM halo-mass function using an extreme value statistics approach. We find that the $z=4.62$ objects and the $z=3.19$ object are unlikely within our area under the assumption of standard stellar fractions ($f_*\simeq 0.1-0.2$). However, these objects roughly align with the most massive galaxies expected under the assumption of 100 per cent conversion of baryons to stars ($f_*$=1). Our results suggest extreme galaxy formation physics during the first billion years, but no conflict with $\Lambda$-CDM cosmology.
Hot gas accretion fuels star formation faster than cold accretion in high-redshift galaxies
Authors: Kocjan Zuzanna , Cadiou Corentin , Agertz Oscar , Pontzen Andrew 
Published: September 2024

ABSTRACT
We use high-resolution ($\simeq$35pc) hydrodynamical simulations of galaxy formation to investigate the relation between gas accretion and star formation in galaxies hosted by dark matter haloes of mass $10^{12}$${{\mathrm{M}}_{\odot }}$ at $z = 2$. At high-redshift, cold-accreted gas is expected to be readily available for star formation, while gas accreted in a hot mode is expected to require a longer time to cool down before being able to form stars. Contrary to these expectations, we find that the majority of cold-accreted gas takes several hundred Myr longer to form stars than hot-accreted gas after it reaches the inner circumgalactic medium (CGM). Approximately 10 per cent of the cold-accreted gas flows rapidly through the inner CGM on to the galactic disc. The remaining 90 per cent is trapped in a turbulent accretion region that extends up to $\sim 50$ per cent of the virial radius, from which it takes several hundred Myr for the gas to be transported to the star-forming disc. In contrast, most hot shock-heated gas avoids this ‘slow track’, and accretes directly from the CGM on to the disc where stars can form. We find that shock-heating of cold gas after accretion in the inner CGM and supernova-driven outflows contribute to, but do not fully explain, the delay in star formation. These processes combined slow down the delivery of cold-accreted gas to the galactic disc and consequently limit the rate of star formation in Milky Way mass galaxies at $z \gt 2$.
Assessment of gradient-based samplers in standard cosmological likelihoods
Authors: Mootoovaloo Arrykrishna , Ruiz-Zapatero Jaime , García-García Carlos , Alonso David 
Published: September 2024

ABSTRACT
We assess the usefulness of gradient-based samplers, such as the no-U-turn sampler (NUTS), by comparison with traditional Metropolis–Hastings (MH) algorithms, in tomographic $3\times 2$ point analyses. Specifically, we use the Dark Energy Survey (DES) Year 1 data and a simulated dataset for the Large Synoptic Survey Telescope (LSST) survey as representative examples of these studies, containing a significant number of nuisance parameters (20 and 32, respectively) that affect the performance of rejection-based samplers. To do so, we implement a differentiable forward model using jax-cosmo, and we use it to derive parameter constraints from both data sets using the nuts algorithm implemented in numpyro, and the Metropolis–Hastings algorithm as implemented in cobaya. When quantified in terms of the number of effective number of samples taken per likelihood evaluation, we find a relative efficiency gain of $\mathcal {O}(10)$ in favour of NUTS. However, this efficiency is reduced to a factor $\sim 2$ when quantified in terms of computational time, since we find the cost of the gradient computation (needed by nuts) relative to the likelihood to be $\sim 4.5$ times larger for both experiments. We validate these results making use of analytical multivariate distributions (a multivariate Gaussian and a Rosenbrock distribution) with increasing dimensionality. Based on these results, we conclude that gradient-based samplers such as NUTS can be leveraged to sample high-dimensional parameter spaces in Cosmology, although the efficiency improvement is relatively mild for moderate ($\mathcal {O}(50)$) dimension numbers, typical of tomographic large-scale structure analyses.
The effect of cosmic web filaments on galaxy evolution
Authors: O’Kane Callum J , Kuchner Ulrike , Gray Meghan E , Aragón-Salamanca Alfonso 
Published: September 2024

ABSTRACT
Galaxy properties are known to be affected by their environment. This is well established for the extremes of the density scales, between the high-density cluster environment and the low-density field. It is, however, not fully understood how the intermediate-density regime of cosmic web filaments affects galaxy evolution. We investigate this environmental effect using a mass complete sample of 23 441 galaxies in the Sloan Digital Sky Survey DR8 Main Galaxy Sample (${M}_{\text{Stellar}} \gt 10^{9.91} \text{M}_{\odot }$). We define six environments, probing different density regimes and representing unique stages in the structure formation process, comparing the differences in star formation activity and morphology between them. We find that galaxies in filaments tend to be less star-forming and favour more early-type morphologies than those in the field. These differences persist when considering stellar mass-matched samples, suggesting that this is a consequence of the environment. We further investigate whether these trends are a result of the large-scale or local environment through constructing samples matched both in stellar mass and local galaxy density. We find that when also matching in local galaxy density, the differences observed between the filament and field population vanishes, concluding that the environmental effect of filaments can be entirely parametrized by a local galaxy density index. We find that differences can still be seen in comparisons with the interiors of clusters, suggesting these are unique environments which can impart additional physical processes not characterized by local galaxy density.
Elucidating the z-dependence of the MOND acceleration (a0) within the scale invariant vacuum (SIV) paradigm
Authors: Gueorguiev Vesselin G 
Published: September 2024

ABSTRACT
In a recent paper: “On the time dependency of $a_0$” the authors claim that they have tested “one of the predictions of the Scale Invariant Vacuum (SIV) theory on MOND” by studying the dependence of the Modified Newtonian Dynamics (MOND) acceleration at two data sets, low-z ($3.2\times 10^{-4}\le z\le 3.2\times 10^{-2}$) and high-z ($0.5\le z\le 2.5$). They claim “both samples show a dependency of $a_0$ from z”. Here, the work mentioned above is revisited. The explicit analytic expression for the z-dependence of the $a_0$ within the SIV theory is given. Furthermore, the first estimates of the $\Omega _m$ within SIV theory give $\Omega _{m}=0.28\pm 0.04$ using the low-z data only, while a value of $\Omega _{m}=0.055$ is obtained using both data sets. This much lower $\Omega _m$ leaves no room for non-baryonic matter! Unlike in the mentioned paper above, the slope in the z-dependence of $A_0=\log _{10}(a_0)$ is estimated to be consistent with zero Z-slope for the two data sets. Finally, the statistics of the data are consistent with the SIV predictions; in particular, the possibility of change in the sign of the slopes for the two data sets is explainable within the SIV paradigm; however, the uncertainty in the data is too big for the clear demonstration of a z-dependence yet.
The Fate of a Polygenic Phenotype Within the Genomic Landscapes of Introgression in the European Seabass Hybrid Zone
Authors: Leitwein Maeva , Durif Ghislain , Delpuech Emilie , Gagnaire Pierre-Alexandre , Ernande Bruno , Vandeputte Marc , Vergnet Alain , Duranton Maud , Clota Frederic , Allal François 
Published: September 2024

Abstract
Unraveling the evolutionary mechanisms and consequences of hybridization is a major concern in biology. Many studies have documented the interplay between recombination and selection in modulating the genomic landscape of introgression, but few have considered how associations with phenotype may affect this landscape. Here, we use the European seabass (Dicentrarchus labrax), a key species in marine aquaculture that undergoes natural hybridization, to determine how selection on phenotype modulates the introgression landscape between Atlantic and Mediterranean lineages. We use a high-density single nucleotide polymorphism array to assess individual local ancestry along the genome and improve the mapping of muscle fat content, a polygenic trait that is divergent between lineages. Taking into account variation in recombination rates, we reveal a purging of Atlantic ancestry in the admixed Mediterranean populations. While Atlantic individuals had higher muscle fat content, we observed that genomic regions associated with this trait in Mediterranean populations displayed reduced introgression of Atlantic ancestry. These results emphasize how selection against maladapted alleles shapes the genomic landscape of introgression.
Nietzsche contra Schopenhauer on Art and Truth
Authors: Page Jeremy 
Published: September 2024

ABSTRACT
Part of Plato’s complaint about the cognitive status of art cites the pollution of aesthetic cognition by the affective side of our natures. Schopenhauer, by contrast, takes aesthetic cognition to transcend (some of) the limitations of everyday cognition precisely because in it agents become the “pure, will-less subject of cognition” (WWR I 219). On the orthodox reading of his later philosophy, Nietzsche scorns Plato and Schopenhauer’s association of the value of art with its truthfulness. I challenge the orthodox reading and argue that one strand of art’s value is its penetrative cognitive power. In contrast to Schopenhauer, Nietzsche understands this cognitive power to result from the embracing and exploitation of the affects in the artistic process rather than their extirpation.
DNA breathing integration with deep learning foundational model advances genome-wide binding prediction of human transcription factors
Authors: Kabir Anowarul , Bhattarai Manish , Peterson Selma , Najman-Licht Yonatan , Rasmussen Kim Ø , Shehu Amarda , Bishop Alan R , Alexandrov Boian , Usheva Anny 
Published: September 2024

Abstract
It was previously shown that DNA breathing, thermodynamic stability, as well as transcriptional activity and transcription factor (TF) bindings are functionally correlated. To ascertain the precise relationship between TF binding and DNA breathing, we developed the multi-modal deep learning model EPBDxDNABERT-2, which is based on the Extended Peyrard-Bishop-Dauxois (EPBD) nonlinear DNA dynamics model. To train our EPBDxDNABERT-2, we used chromatin immunoprecipitation sequencing (ChIP-Seq) data comprising 690 ChIP-seq experimental results encompassing 161 distinct TFs and 91 human cell types. EPBDxDNABERT-2 significantly improves the prediction of over 660 TF-DNA, with an increase in the area under the receiver operating characteristic (AUROC) metric of up to 9.6% when compared to the baseline model that does not leverage DNA biophysical properties. We expanded our analysis to in vitro high-throughput Systematic Evolution of Ligands by Exponential enrichment (HT-SELEX) dataset of 215 TFs from 27 families, comparing EPBD with established frameworks. The integration of the DNA breathing features with DNABERT-2 foundational model, greatly enhanced TF-binding predictions. Notably, EPBDxDNABERT-2, trained on a large-scale multi-species genomes, with a cross-attention mechanism, improved predictive power shedding light on the mechanisms underlying disease-related non-coding variants discovered in genome-wide association studies.
Sleep disorders associated with cranial radiation—A systematic review
Authors: Pascoe Maeve , Byrne Emma , King Amanda , Cooper Diane , Foldvary-Schaefer Nancy , Mehra Reena , Lathia Justin , Gilbert Mark R , Armstrong Terri S 
Published: September 2024

Abstract

Background
Radiation is the standard-of-care treatment for primary brain tumors (PBTs) but may have profound effects on sleep that have not yet been fully characterized. This systematic review aims to further our understanding of radiation therapy on the risk of development of sleep disorders in patients with PBTs, as well as potential opportunities for prevention and treatment.

Methods
A systematic search of PubMed, Embase, and Web of Science was performed (last Jan 2024) with predefined inclusion (PBT patients, radiation therapy, somnolence/circadian disruption) and exclusion (reviews/abstracts/cases/chapters, non-PBT cancer, lack of radiation) criteria, yielding 267 papers initially and 38 studies included. Data extraction and analysis (descriptive statistics, individual study summary) focused on the incidence of sleep disturbances, radiation types/doses, and pharmacologic interventions. Risk of bias assessment was conducted with the Effective Public Health Practice Project’s Quality Assessment Tool for Quantitative Studies.

Results
The included 38 studies (n = 2948 patients) demonstrated a high incidence of sleep disturbances in patients with PBTs throughout radiation therapy, but primarily from the end of radiation to 6 months after. Sleep symptoms were associated with radiation (dose-dependent), and pharmacotherapies were helpful in patients with formal sleep disorder diagnoses. Terminology and incidence reporting of sleep symptoms are inconsistent, and many studies had a high risk of bias.

Conclusions
This systematic review highlights the ongoing challenges with sleep symptoms/disorders related to cranial irradiation treatment in the primary brain tumor population. Further investigations on the interconnectedness of sleep disturbance constructs and possible pharmacotherapies to alleviate symptoms are warranted.
Unlocking nitrogen management potential via large-scale farming for air quality and substantial co-benefits
Authors: Li Baojie , Liao Hong , Li Ke , Wang Ye , Zhang Lin , Guo Yixin , Liu Lei , Li Jingyi , Jin Jianbing , Yang Yang , Gong Cheng , Wang Teng , Shen Weishou , Wang Pinya , Dang Ruijun , Liao Kaihua , Zhu Qing , Jacob Daniel J 
Published: September 2024

ABSTRACT
China's sustained air quality improvement is hindered by unregulated ammonia (NH3) emissions from inefficient nitrogen management in smallholder farming. Although the Chinese government is promoting a policy shift to large-scale farming, the benefits of this, when integrated with nitrogen management, remain unclear. Here we fill this gap using an integrated assessment, by combining geostatistical analysis, high-resolution emission inventories, farm surveys and air quality modeling. Smallholder-dominated farming allows only 13%–31% NH3 reduction, leading to limited PM2.5 decreases nationally due to non-linear PM2.5 chemistry. Conversely, large-scale farming would double nitrogen management adoption rates, increasing NH3 reduction potential to 48%–58% and decreasing PM2.5 by 9.4–14.0 μg·m−3 in polluted regions. The estimated PM2.5 reduction is conservative due to localized NH3-rich conditions under large-scale livestock farming. This strategy could prevent over 300 000 premature deaths and achieve a net benefit of US $68.4–86.8 billion annually, unlocking immense benefits for air quality and agricultural sustainability.