bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory extracorporeal membrane oxygenation for severe sepsis and septic shock in adults: a propensity score analysis in a multicenter retrospective observational study
Authors: Takauji Shuhei , Hayakawa Mineji , Ono Kota , Makise Hiroshi 
Published: July 2017

AimThis multicenter retrospective observational study aimed to evaluate the efficacy of extracorporeal membrane oxygenation (ECMO) support for septic patients with severe respiratory failure using propensity score analyses.MethodsThe data of severe sepsis patients from 42 intensive care units between January 2011 and December 2013 were retrospectively collected. Propensity score matching analyses were undertaken for severe respiratory failure patients with/without veno‐venous ECMO support. The main outcome was in‐hospital all‐cause mortality.ResultsOf 3195 patients with severe sepsis, 570 had severe respiratory failure. Forty patients in the ECMO group were matched with 150 patients in the control group. A survival time analysis revealed no difference in the in‐hospital survival (hazard ratio, 0.854; 95% confidence interval, 0.531–1.373; P = 0.515). Two‐hundred and eighty‐five patients had severe respiratory failure induced by lung infection. Twenty‐five ECMO group patients were matched with 89 patients in the control group. In the ECMO group, the survival time was longer than in the control group (hazard ratio, 0.498; 95% confidence interval, 0.279–0.889; P = 0.018). The number of renal replacement therapy‐ and vasopressor‐free days improved. The ECMO group received more red blood cells transfused than the control group, but there was no significant difference in the rate of severe bleeding complications between the groups.ConclusionsThere was no difference in the in‐hospital survival between the ECMO group and control group among overall septic patients with severe respiratory failure. However, in sepsis patients with severe respiratory failure induced by lung infection, ECMO support may improve their survival time.
Tailored Engineering of an Unusual (C4H9NH3)2(CH3NH3)2Pb3Br10 Two‐Dimensional Multilayered Perovskite Ferroelectric for a High‐Performance Photodetector
Authors: Li Lina , Sun Zhihua , Wang Peng , Hu Weida , Wang Sasa , Ji Chengmin , Hong Maochun , Luo Junhua 
Published: July 2017

AbstractTwo‐dimensional (2D) layered hybrid perovskites have shown great potential in optoelectronics, owing to their unique physical attributes. However, 2D hybrid perovskite ferroelectrics remain rare. The first hybrid ferroelectric with unusual 2D multilayered perovskite framework, (C4H9NH3)2(CH3NH3)2Pb3Br10 (1), has been constructed by tailored alloying of the mixed organic cations into 3D prototype of CH3NH3PbBr3. Ferroelectricity is created through molecular reorientation and synergic ordering of organic moieties, which are unprecedented for the known 2D multilayered hybrid perovskites. Single‐crystal photodetectors of 1 exhibit fascinating performances, including extremely low dark currents (ca. 10−12 A), large on/off current ratios (ca. 2.5×103), and very fast response rate (ca. 150 μs). These merits are superior to integrated detectors of other 2D perovskites, and compete with the most active CH3NH3PbI3.
Insights into Magnetic Interactions in a Monodisperse Gd12Fe14 Metal Cluster
Authors: Zheng Xiu‐Ying , Zhang Hui , Wang Zhenxing , Liu Pengxin , Du Ming‐Hao , Han Ying‐Zi , Wei Rong‐Jia , Ouyang Zhong‐Wen , Kong Xiang‐Jian , Zhuang Gui‐Lin , Long La‐Sheng , Zheng Lan‐Sun 
Published: July 2017

AbstractThe largest Ln–Fe metal cluster [Gd12Fe14(μ3‐OH)12(μ4‐OH)6(μ4‐O)12(TEOA)6(CH3COO)16(H2O)8]⋅(CH3COO)2(CH3CN)2⋅(H2O)20 (1) and the core–shell monodisperse metal cluster of 1 a@SiO2 (1 a=[Gd12Fe14(μ3‐OH)12(μ4‐OH)6(μ4‐O)12(TEOA)6(CH3COO)16 (H2O)8]2+) were prepared. Experimental and theoretical studies on the magnetic properties of 1 and 1 a@SiO2 reveal that encapsulation of one cluster into one silica nanosphere not only effectively decreases intermolecular magnetic interactions but also significantly increases the zero‐field splitting effect of the outer layer Fe3+ ions.
Genome‐Wide Association Meta‐Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci
Authors: McIntosh Laura A. , Marion Miranda C. , Sudman Marc , Comeau Mary E. , Becker Mara L. , Bohnsack John F. , Fingerlin Tasha E. , Griffin Thomas A. , Haas J. Peter , Lovell Daniel J. , Maier Lisa A. , Nigrovic Peter A. , Prahalad Sampath , Punaro Marilynn , Rosé Carlos D. , Wallace Carol A. , Wise Carol A. , Moncrieffe Halima , Howard Timothy D. , Langefeld Carl D. , Thompson Susan D. 
Published: July 2017

ObjectiveJuvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and has a strong genomic component. To date, JIA genetic association studies have had limited sample sizes, used heterogeneous patient populations, or included only candidate regions. The aim of this study was to identify new associations between JIA patients with oligoarticular disease and those with IgM rheumatoid factor (RF)−negative polyarticular disease, which are clinically similar and the most prevalent JIA disease subtypes.MethodsThree cohorts comprising 2,751 patients with oligoarticular or RF‐negative polyarticular JIA were genotyped using the Affymetrix Genome‐Wide SNP Array 6.0 or the Illumina HumanCoreExome‐12+ Array. Overall, 15,886 local and out‐of‐study controls, typed on these platforms or the Illumina HumanOmni2.5, were used for association analyses. High‐quality single‐nucleotide polymorphisms (SNPs) were used for imputation to 1000 Genomes prior to SNP association analysis.ResultsMeta‐analysis showed evidence of association (P < 1 × 10−6) at 9 regions: PRR9_LOR (P = 5.12 × 10−8), ILDR1_CD86 (P = 6.73 × 10−8), WDFY4 (P = 1.79 × 10−7), PTH1R (P = 1.87 × 10−7), RNF215 (P = 3.09 × 10−7), AHI1_LINC00271 (P = 3.48 × 10−7), JAK1 (P = 4.18 × 10−7), LINC00951 (P = 5.80 × 10−7), and HBP1 (P = 7.29 × 10−7). Of these, PRR9_LOR, ILDR1_CD86, RNF215, LINC00951, and HBP1 were shown, for the first time, to be autoimmune disease susceptibility loci. Furthermore, associated SNPs included cis expression quantitative trait loci for WDFY4, CCDC12, MTP18, SF3A1, AHI1, COG5, HBP1, and GPR22.ConclusionThis study provides evidence of both unique JIA risk loci and risk loci overlapping between JIA and other autoimmune diseases. These newly associated SNPs are shown to influence gene expression, and their bounding regions tie into molecular pathways of immunologic relevance. Thus, they likely represent regions that contribute to the pathology of oligoarticular JIA and RF‐negative polyarticular JIA.
Natural Compounds in Cancer Prevention: Effects of Coffee Extracts and Their Main Polyphenolic Component, 5‐O‐Caffeoylquinic Acid, on Oncogenic Ras Proteins
Authors: Palmioli Alessandro , Ciaramelli Carlotta , Tisi Renata , Spinelli Michela , De Sanctis Gaia , Sacco Elena , Airoldi Cristina 
Published: July 2017

AbstractRecent epidemiological studies have demonstrated that the consumption of healthy foods that are particularly rich in polyphenols might reduce the incidence of cancer and neurodegenerative diseases. In particular, chlorogenic acids (CGAs) occur ubiquitously in food and represent the most abundant polyphenols in the human diet. A number of beneficial biological effects of CGAs, such as anti‐inflammatory activity, anti‐carcinogenic activity, and protection against neurodegenerative diseases, have been reported. However, the molecular mechanisms at the base of these biological activities have not yet been investigated in depth. By combining NMR spectroscopy, molecular docking, surface plasmon resonance and ex vivo assays of the Ras‐dependent breast cancer cell line MDA‐MB‐231, we contribute to the elucidation of the molecular basis of the activity of CGAs and natural extracts from green and roasted coffee beans as chemoprotective dietary supplements.
A Pyridoindole‐Based Multifunctional Bioprobe: pH‐Induced Fluorescence Switching and Specific Targeting of Lipid Droplets
Authors: Sk Bahadur , Thakre Pilendra Kumar , Tomar Raghuvir Singh , Patra Abhijit 
Published: July 2017

AbstractA versatile fluorescent probe, PITE, based on alkyl‐substituted pyridoindole (PI) and tetraphenylethylene (TE), which exhibits facile pH‐induced fluorescence switching in solution, as nanoparticles, and in the solid state, is presented. Strong fluorescence in the solid state, as well as in solution and the aggregated state, allow sensing of toxic acid vapors. Fluorescence “off–on” switching of PITE through exposure to trifluoroacetic acid and triethylamine vapor is visualized by the naked eye. A unified picture of the switchable fluorescence of PITE is obtained by comprehensive spectroscopic investigations coupled with quantum mechanical calculations. Strong fluorescence, a large Stokes shift, high photostability, and biocompatibility of PITE make it a viable probe for subcellular imaging. Extensive fluorescence microscopic studies by employing organisms including lower and higher eukaryotes reveal specific localization of PITE to lipid droplets (LDs). LDs are dynamic subcellular organelles linked to various physiological processes and human diseases. Hence, the specific detection of LDs in diverse organisms is important to biomedical research and healthcare. Isolation of LDs and subsequent colocalization studies ascertain selective targeting of LDs by the easily affordable, lipophilic bioprobe, PITE. Thus, PITE is a promising multifunctional probe for chemosensing and the selective tracking of LDs.
Uncertain Saturated Discrete‐Time Sliding Mode Control for A Wind Turbine Using A Two‐Mass Model
Authors: Zaafouri Chaker , Torchani Borhen , Sellami Anis , Garcia Germain 
Published: July 2017

AbstractThe aim of this paper is to propose a new design variable speed wind turbine control by discrete‐time sliding mode approach. The control objective is to obtain a maximum extraction of wind energy, while reducing mechanical loads and rotor speed tracking combined with an electromagnetic torque. For this application, we designed a discrete time sliding mode control using the equivalent discrete time reaching law. Furthermore, a systematic and improved design procedure for uncertainties discrete‐time sliding mode control (SMC) with saturation problem is provided in this paper. The saturation constraint is reported on inputs vector. LMI technique and polytopic models are used in the design of the switching surface. To achieve some performance requirements and good robustness, in the sliding mode, the pole clustering method is investigated. Based on the unit vector control approach, a robust control is developed, then, to direct and maintain the system states onto the sliding manifold in finite time. Finally, a systematic design procedure for DSMC required to achieve a given performance level is provided and its effectiveness is varied by applying it to variable speed wind turbine systems.
Metformin synergistic pemetrexed suppresses non‐small‐cell lung cancer cell proliferation and invasion in vitro
Authors: Zhang Yan , Feng Xiuli , Li Tao , Yi Erpan , Li Yu 
Published: July 2017

AbstractThe aim of this study was to investigate whether metformin in combination with pemetrexed has an effect on the treatment of non‐small‐cell lung cancer (NSCLC) models and to explore the related molecular mechanism. The half maximal inhibitory concentration (IC50) and combination index (CI) of metformin and pemetrexed were detected by the CCK8 assay to assess the antiproliferative and therapeutic effects of the two‐drug combination. Flow cytometry (FCM) and invasion assays were used to estimate the variation in apoptosis rate and invasion ability of the differently treated NSCLC cell lines. Apoptotic markers were detected by western blotting to validate the data related to the antiproliferation and proapoptosis effects. Metformin monotherapy inhibited the growth of NSCLC cell lines and reduced the invasion ability to different degrees compared with the control groups (P < 0.05). Metformin in combination with pemetrexed produced a synergistic effect (CI < 0.90) compared with the two drugs in monotherapy in the three tested NSCLC cell lines. Metformin in combination with pemetrexed significantly increased the cell numbers of HCC827 cells at S phase (P < 0.001), and the combination therapy had no influence on the A549 and H1975 cell lines. We found that combining metformin with pemetrexed induced more cell apoptosis than metformin or pemetrexed used alone (P < 0.05), which was validated by the apoptotic markers. These results demonstrate that the combination of metformin and pemetrexed has a synergistic effect on the treatment of NSCLC cell lines by inducing apoptosis or blocking the cell cycle. Our data indicate that the combination of metformin and pemetrexed could have beneficial antitumor effects on NSCLC cells in vitro.
A first‐in‐human phase I, multicenter, open‐label, dose‐escalation study of the oral RAF/VEGFR‐2 inhibitor (RAF265) in locally advanced or metastatic melanoma independent from BRAF mutation status
Authors: Izar Benjamin , Sharfman William , Hodi F. Stephen , Lawrence Donald , Flaherty Keith T. , Amaravadi Ravi , Kim Kevin B. , Puzanov Igor , Sosman Jeffrey , Dummer Reinhard , Goldinger Simone M. , Lam Lyhping , Kakar Shefali , Tang Zhongwen , Krieter Oliver , McDermott David F. , Atkins Michael B. 
Published: July 2017

AbstractTo establish the maximum tolerated dose (MTD), dose‐limiting toxicities (DLT), safety profile, and anti‐tumor efficacy of RAF265. We conducted a multicenter, open‐label, phase‐I, dose‐escalation trial of RAF265, an orally available RAF kinase/VEGFR‐2 inhibitor, in patients with advanced or metastatic melanoma. Pharmacokinetic (PK) analysis, pharmacodynamics (PD) and tumor response assessment were conducted. We evaluated metabolic tumor response by 18[F]‐fluorodeoxyglucose‐positron‐emission tomography (FDG‐PET), tissue biomarkers using immunohistochemistry (IHC), and modulators of angiogenesis. RAF265 has a serum half‐life of approximately 200 h. The MTD was 48 mg once daily given continuously. Among 77 patients, most common treatment‐related adverse effects were fatigue (52%), diarrhea (34%), weight loss (31%) and vitreous floaters (27%). Eight of 66 evaluable patients (12.1%) had an objective response, including seven partial and one complete response. Responses occurred in BRAF‐mutant and BRAF wild‐type (WT) patients. Twelve of 58 (20.7%) evaluable patients had a partial metabolic response. On‐treatment versus pretreatment IHC staining in 23 patients showed dose‐dependent p‐ERK inhibition. We observed a significant temporal increase in placental growth factor levels and decrease in soluble vascular endothelial growth factor receptor 2 (sVEGFR‐2) levels in all dose levels. RAF265 is an oral RAF/VEGFR‐2 inhibitor that produced antitumor responses, metabolic responses, and modulated angiogenic growth factor levels. Antitumor activity occurred in patients with BRAF‐mutant and BRAF‐WT disease. Despite low activity at tolerable doses, this study provides a framework for the development of pan‐RAF inhibitors and modulators of angiogenesis for the treatment of melanoma.
Synthesis of C‐Glucosylated Octaketide Anthraquinones in Nicotiana benthamiana by Using a Multispecies‐Based Biosynthetic Pathway
Authors: Andersen‐Ranberg Johan , Kongstad Kenneth Thermann , Nafisi Majse , Staerk Dan , Okkels Finn Thyge , Mortensen Uffe Hasbro , Lindberg Møller Birger , Frandsen Rasmus John Normand , Kannangara Rubini 
Published: July 2017

AbstractCarminic acid is a C‐glucosylated octaketide anthraquinone and the main constituent of the natural dye carmine (E120), possessing unique coloring, stability, and solubility properties. Despite being used since ancient times, longstanding efforts to elucidate its route of biosynthesis have been unsuccessful. Herein, a novel combination of enzymes derived from a plant (Aloe arborescens, Aa), a bacterium (Streptomyces sp. R1128, St), and an insect (Dactylopius coccus, Dc) that allows for the biosynthesis of the C‐glucosylated anthraquinone, dcII, a precursor for carminic acid, is reported. The pathway, which consists of AaOKS, StZhuI, StZhuJ, and DcUGT2, presents an alternative biosynthetic approach for the production of polyketides by using a type III polyketide synthase (PKS) and tailoring enzymes originating from a type II PKS system. The current study showcases the power of using transient expression in Nicotiana benthamiana for efficient and rapid identification of functional biosynthetic pathways, including both soluble and membrane‐bound enzymes.
Oral manifestations of a rare variant of Marfan syndrome
Authors: Sinha Abhishek , Kaur Sandeep , Raheel Syed Ahmed , Kaur Kirandeep , Alshehri Mohammed , Kujan Omar 
Published: July 2017

Key Clinical MessageThis article reports the oral manifestations of an unusual presentation of Marfan syndrome (MFS) and provides an evidence to the importance of recognizing the oral features in confirming the diagnosis of MFS. Dentists have a vital role in confirming the diagnosis of developmental disorders that involve the craniofacial compendium.
Boron and Boron‐Containing Catalysts for the Oxidative Dehydrogenation of Propane
Authors: Grant Joseph T. , McDermott William P. , Venegas Juan M. , Burt Samuel P. , Micka Jack , Phivilay Somphonh P. , Carrero Carlos A. , Hermans Ive 
Published: July 2017

AbstractBoron nitride was recently identified as a highly selective catalyst for the oxidative dehydrogenation of propane. In this communication, we report that other boron‐containing materials such as boron carbide, titanium boride, nickel boride, cobalt boride, hafnium boride, and tungsten boride, as well as elemental boron itself, show the same exceptional behavior as boron nitride. X‐ray photoelectron and infrared spectroscopy suggest oxyfunctionalization of the surface. This observation disproves previous mechanistic hypotheses that edge sites on the boron nitride would be the active sites and rather suggests the formation of an analogous surface‐stabilized BOx active site for all tested boride catalysts.
Water‐Based Synthesis of Sub‐10 nm Pt Octahedra and Their Performance towards the Oxygen Reduction Reaction
Authors: Lee Chi‐Ta , Yang Xuan , Vara Madeline , Gilroy Kyle D. , Xia Younan 
Published: July 2017

AbstractWe report a facile, aqueous‐phase synthesis of sub‐10 nm Pt octahedral nanocrystals. The success of this synthesis relies on the use of poly(vinyl pyrrolidone) (PVP) as a mediator. By tracking the evolution of the Pt nanocrystals throughout the growth process, we found that single‐crystal seeds with a pseudo‐spherical shape are formed in the early stage of the synthesis, followed by growth through the preferential deposition of Pt atoms onto the {100} facets, directing the seeds to evolve into octahedra enclosed by {111} facets. We have manipulated the atom deposition rates by tuning various experimental parameters in an effort to support the mechanism for the formation of Pt octahedra. In addition, we have investigated the catalytic activity of these Pt nanocrystals towards oxygen reduction. For the 9‐nm Pt octahedra enclosed by {111} facets, they show a specific activity of 1.5 mA cm−2, much greater than that of Pt nanocubes enclosed by {100} facets, which only has a specific activity of 0.28 mA cm−2.
Lignin‐Retaining Transparent Wood
Authors: Li Yuanyuan , Fu Qiliang , Rojas Ramiro , Yan Min , Lawoko Martin , Berglund Lars 
Published: July 2017

AbstractOptically transparent wood, combining optical and mechanical performance, is an emerging new material for light‐transmitting structures in buildings with the aim of reducing energy consumption. One of the main obstacles for transparent wood fabrication is delignification, where around 30 wt % of wood tissue is removed to reduce light absorption and refractive index mismatch. This step is time consuming and not environmentally benign. Moreover, lignin removal weakens the wood structure, limiting the fabrication of large structures. A green and industrially feasible method has now been developed to prepare transparent wood. Up to 80 wt % of lignin is preserved, leading to a stronger wood template compared to the delignified alternative. After polymer infiltration, a high‐lignin‐content transparent wood with transmittance of 83 %, haze of 75 %, thermal conductivity of 0.23 W mK−1, and work‐tofracture of 1.2 MJ m−3 (a magnitude higher than glass) was obtained. This transparent wood preparation method is efficient and applicable to various wood species. The transparent wood obtained shows potential for application in energy‐saving buildings.
Preparation of Layered‐Spinel Microsphere/Reduced Graphene Oxide Cathode Materials for Ultrafast Charge–Discharge Lithium‐Ion Batteries
Authors: Luo Dong , Fang Shaohua , Yang Li , Hirano Shin‐ichi 
Published: July 2017

AbstractAlthough Li‐rich layered oxides (LLOs) have the highest capacity of any cathodes used, the rate capability of LLOs falls short of meeting the requirements of electric vehicles and smart grids. Herein, a layered‐spinel microsphere/reduced graphene oxide heterostructured cathode (LS@rGO) is prepared in situ. This cathode is composed of a spinel phase, two layered structures, and a small amount of reduced graphene oxide (1.08 wt % of carbon). The assembly delivers a considerable charge capacity (145 mA h g−1) at an ultrahigh charge– discharge rate of 60 C (12 A g−1). The rate capability of LS@rGO is influenced by the introduced spinel phase and rGO. X‐ray absorption and X‐ray photoelectron spectroscopy data indicate that Cr ions move from octahedral lattice sites to tetrahedral lattice sites, and that Mn ions do not participate in the oxidation reaction during the initial charge process.
ACMHS: Efficient access control for mobile health care system
Authors: Wan Changsheng , Zhang Juan , Huang Daoli 
Published: July 2017

SummaryTo provide privacy protection in mobile health care system, medical users typically encrypt their personal health information before publishing it to the health care center. And other medical users download, decrypt, and process it using an access control protocol. However, current access control protocols are mainly focusing the privacy of personal health information and lacking the protection for medical users' real identities, leading to a variety of security issues. At the same time, current access control protocols for mobile health care systems are usually based on bilinear map, resulting in high computation costs. Observing the above issues, we introduce a novel access control protocol with privacy‐preserving called Access Control for Mobile Healthcare System (ACMHS). Similar to protocols of this field, ACMHS can provide privacy protection for mobile health care systems. However, different from other well‐known approaches, ACMHS uses pseudonyms instead of real identities, which can provide privacy protection for medical users' real identities. Moreover, to reduce the computation cost of bilinear map, we introduce the algebraic signature to ACMHS and design a novel access control protocol, which is much more efficient than current bilinear‐map‐based protocols. By doing so, ACMHS can achieve high efficiency while still enjoying required security requirements. Experimental results show that ACMHS is feasible for real‐world applications.