bluuebunny/crossref_metadata_2025_split huggingface dataset:
MANAGEMENT OF ENDOCRINE DISEASE: Flushing: current concepts
Authors: Huguet Isabel , Grossman Ashley 
Published: October 2017

ObjectiveFlushing can be defined as a sensation of warmth accompanied by erythema that most commonly is seen on the face and which occurs in episodic attacks. Such a problem can be clinically problematic, since many conditions and drugs can be related to flushing, and while often there appears to be no underlying organic disease, it is important to exclude disorders since they may be life-threatening conditions.Design and methodsWe performed a search in MEDLINE using the terms ‘flushing’ in combination with ‘carcinoid syndrome’, ‘pheochromocytoma’, ‘mastocytosis’, ‘menopausal hot flush’ and ‘treatment’. European and American guidelines relating to neuroendocrine tumours, mastocytosis and menopause were reviewed.ResultsIn this review, we discuss the main causes of flushing and propose an algorithm based on pathogenesis, which can be used to guide the clinical evaluation process. We also review recent significant developments in the assessment and treatment of the carcinoid syndrome and menopausal hot flushes, which should guide the clinical practice regarding this common but sometimes confusing condition.ConclusionsWhen evaluating flushing, a precise systematic approach is needed to exclude potentially serious underlying causes, although despite this, the cause of the disorder is not always found. If symptoms are not progressive, the patient should be advised about its apparently benign nature in order to avoid unnecessary studies or initiating treatments of minimal benefit.
Somatic USP8 mutations are frequent events in corticotroph tumor progression causing Nelson’s tumor
Authors: Pérez-Rivas Luis G , Theodoropoulou Marily , Puar Troy H , Fazel Julia , Stieg Mareike R , Ferraù Francesco , Assié Guillaume , Gadelha Monica R , Deutschbein Timo , Fragoso Maria C , Kusters Benno , Saeger Wolfgang , Honegger Jürgen , Buchfelder Michael , Korbonits Márta , Bertherat Jérôme , Stalla Günter K , Hermus Ad R , Beuschlein Felix , Reincke Martin 
Published: October 2017

Objective
Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene are frequent in corticotroph tumors causing Cushing’s disease (CD). Corticotroph tumor progression, the so-called Nelson’s syndrome (NS), is a potentially life-threatening complication of bilateral adrenalectomy in patients with refractory CD that is caused by the development of an ACTH-secreting tumor of the pituitary gland. Whether USP8 alterations are also present in progressive Nelson’s tumors has not been studied in detail so far.

Design and Methods
Retrospective, multicenter study involving tumors from 33 patients with progressive corticotroph tumors (29 females) and screening for somatic mutations on the mutational hotspot of the USP8 gene in the exon 14 with Sanger sequencing.

Results
Fifteen out of 33 tumors (45%) presented with a mutation in the exon 14 of USP8, with c.2159C>A (p.Pro720Gln) being the most frequent (9/33), followed by c.2155_2157delTCC (p.Ser718del, 4/33) and c.2152T>C (p.Ser718Pro, 2/33). This prevalence is similar to that previously reported for CD. Mutations were found exclusively in females. Other variables, such as age at diagnosis with NS, body mass index, hyperpigmentation, visual field defects, adenoma size or mortality, did not significantly differ between patients with wild-type and mutant tumors. Patients with USP8 mutant tumors exhibited higher levels of plasma ACTH after surgery (median: 640 vs 112 pg/mL, P = 0.03). No differences were observed in ACTH normalization (<50 pg/mL) and tumor control after surgery for Nelson’s tumor.

Conclusion
Somatic mutations in USP8 are common in Nelson’s tumors, indicating that they do not drive the corticotroph tumor progression that leads to NS, and may be associated with a less favorable biochemical outcome after surgery for Nelson’s tumor.
Systematic review of the association between physical activity and burnout
Authors: Naczenski Lea M , de Vries Juriena D , van Hooff Madelon L M , Kompier Michiel A J 
Published: October 2017

Abstract

Objective
Burnout constitutes a health risk, and interventions are needed to reduce it. The aim of this study was to synthesize evidence regarding the relationship between physical activity and burnout by conducting a systematic review of longitudinal and intervention studies.

Methods
A literature search resulted in the identification of a final set of ten studies: four longitudinal and six intervention studies. In separate analyses for each category, evidence was synthesized by extracting the study characteristics and assessing the methodological quality of each study. The strength of evidence was calculated with the standardized index of convergence (SIC).

Results
In longitudinal studies, we found moderately strong evidence (SIC (4) = – 1) for a negative relationship between physical activity and the key component of burnout, i.e., exhaustion. We found strong evidence (SIC (6) = – 0.86) for the effect of physical activity on reducing exhaustion in intervention studies. As only one study could be classified as a high quality study, these results of previous studies need to be interpreted with some caution.

Conclusions
This systematic review suggests that physical activity constitutes an effective medium for the reduction of burnout. Although consistent evidence was found, there is a lack of high quality longitudinal and intervention studies considering the influence of physical activity on burnout. Therefore, future research should be conducted with the aim to produce high quality studies, to develop a full picture of physical activity as a strategy to reduce burnout.
Changes in Influenza Vaccination Rates After Withdrawal of Live Vaccine
Authors: Robison Steve G. , Dunn Aaron G. , Richards Deborah L. , Leman Richard F. 
Published: October 2017

BACKGROUND:
Before the start of the 2016–2017 influenza season, the Advisory Committee on Immunization Practices withdrew its recommendation promoting the use of live attenuated influenza vaccines (LAIVs). There was concern that this might lessen the likelihood that those with a previous LAIV would return for an injectable influenza vaccine (IIV) and that child influenza immunization rates would decrease overall.

METHODS:
Using Oregon's statewide immunization registry, the ALERT Immunization Information System, child influenza immunization rates were compared across the 2012–2013 through 2016–2017 seasons. Additionally, matched cohorts of children were selected based on receipt of either an LAIV or an IIV during the 2015–2016 season. Differences between the IIV and LAIV cohorts in returning for the IIV in the 2016–2017 season were assessed.

RESULTS:
Overall, influenza immunization rates for children aged 2 to 17 years were unchanged between the 2015–2016 and 2016–2017 seasons. Children aged 3 to 10 with a previous IIV were 1.03 (95% confidence interval, 1.02 to 1.04) times more likely to return for an IIV in 2016-2017 than those with a previous LAIV, whereas children aged 11 to 17 years with a previous IIV were 1.08 (95% confidence interval, 1.05 to −1.09) times more likely to return.

CONCLUSIONS:
Withdrawal of the LAIV recommendation was not associated with an overall change in child influenza immunization rates across seasons. Children with a previous (2015–2016) IIV were slightly more likely to return during the 2016–2017 season for influenza immunization than those with a previous LAIV.
The Effect of Reduction Mammaplasty on Quality of Life in Adolescents With Macromastia
Authors: Nuzzi Laura C. , Firriolo Joseph M. , Pike Carolyn M. , Cerrato Felecia E. , Webb Michelle L. , Faulkner Heather R. , DiVasta Amy D. , Labow Brian I. 
Published: October 2017

OBJECTIVES:
To measure changes in health-related quality of life and breast-related symptoms after reduction mammaplasty in adolescents.

METHODS:
In this longitudinal cohort study, we administered the Short-Form 36v2 (SF-36), Rosenberg Self-Esteem Scale (RSES), Breast-Related Symptoms Questionnaire (BRSQ), and Eating Attitudes Test-26 to 102 adolescents with macromastia and 84 female controls, aged 12 to 21 years. Patients with macromastia completed surveys preoperatively and after reduction mammaplasty at 6 months and 1, 3, and 5 years. Controls completed baseline and follow-up surveys at the same intervals.

RESULTS:
Patients with macromastia demonstrated significant score improvements postoperatively from baseline on the RSES, BRSQ, and in 7 out of 8 SF-36 domains: physical functioning, role-physical, bodily pain, vitality, social functioning, role-emotional, mental health (P &lt; .001, all). By the 6-month follow-up visit, postoperative subjects scored similarly to or more favorably than controls on the RSES, BRSQ, Eating Attitudes Test-26 , and SF-36; these benefits persisted for at least 5 years and were not significantly affected by BMI category or age.

CONCLUSIONS:
Reduction mammaplasty was significantly associated with improvements in health-related quality of life and breast-related symptoms of adolescent patients, with measureable improvements in physical and psychosocial well-being evident by 6 months postoperatively and still demonstrable after 5-years. These results largely do not vary by BMI category or age. Patients and providers should be aware of the potential positive impact that reduction mammaplasty can provide adolescents with symptomatic macromastia. Historic concerns regarding age and BMI category at the time of surgery should be reconsidered.
The Bakhshālī Manuscript: A Response to the Bodleian Library's Radiocarbon Dating
Authors: Wujastyk Dominik , Hayashi Takao , Keller Agathe , Montelle Clemency , Plofker Kim 
Published: October 2017

Popular attention has recently been captured by the results of the Bodleian Library's 2017 project of radiocarbon datingportions of the birch-bark fragments constituting what is known as the Bakhshālī Manuscript. In this paper, we disagree with the interpretation of the findings announced by the Bodleian team. In particular, we argue that the earliest dated folio of this manuscript is unlikely to be the date of the whole text. Rather, the latest dateable folio is logically the date of the scribal activity. This fits well with past estimates of the date of the Bakhshālī Manuscript based on historical, philological and palaeographic arguments.. And we argue that the Bakhshālī Manuscript does include written zeros that function as arithmetical operators, i.e., as numbers in their own right, and not merely as place-holders, as asserted by the Bodleian team. Finally, we express regret that the Bodleian Library chose to announce scientific results without peer-review and through a press release to newspapers and a YouTube video.
Socio-economic determinants of asthma and allergic diseases among students of lower secondary schools in Bytom
Authors: Czech Elżbieta , Wypych-Ślusarska Agata , Kasznia-Kocot Joanna , Niewiadomska Ewa , Skrzypek Michał , Słowiński Jerzy , Malinowska-Borowska Jolanta 
Published: October 2017

WstępWdrażanie odpowiednich programów profilaktycznych, minimalizujących skutki astmy bądź umożliwiających jej skuteczną kontrolę wymaga właściwej identyfikacji czynników ryzyka, w tym również uwarunkowań społeczno-ekonomicznych. Celem badania było określenie społeczno-ekonomicznych uwarunkowań astmy oraz chorób alergicznych występujących u dzieci z Bytomia.Materiał i metodyNa przełomie 2011/2012 r. przeprowadzono epidemiologiczne badanie przekrojowe wśród 1099 uczniów szkół gimnazjalnych w Bytomiu. Kwestionariusz, wypełniany przez uczniów, zawierał pytania pochodzące z kwestionariusza stosowanego w badaniu Health Behavior in School-aged Children (HBSC). Badano wpływ skali zasobów materialnych rodziny FAS (Family Affluence Scale) oraz wykształcenia matki na częstość występowania: astmy oskrzelowej, napadów duszności, świszczącego oddechu, alergii na kurz, pyłki roślin oraz sierść zwierząt, a także na częstość wykonywania testów alergicznych. Analiza danych została przeprowadzona w programie Statistica 10.0. Przyjęto poziom znamienności statystycznej p < 0,05.WynikiCzęstość rozpoznanej kiedykolwiek astmy oskrzelowej wynosiła 9,9%, napadów duszności 24,4% oraz świszczącego oddechu 17,5% i problemy te częściej występowały u dzieci z rodzin o niskim FAS. Astma oskrzelowa częściej dotyczy dzieci, których matki legitymują się wykształceniem podstawowym lub zawodowym. Dzieci z rodzin o wysokim statusie społeczno-ekonomicznym (wysoki poziom skali FAS i wyższe wykształcenie matek) częściej mają wykonywane testy alergiczne i częściej też zgłaszają alergię na kurz domowy, pyłki roślin oraz sierść zwierząt.WnioskiPrzeprowadzone badanie wskazuje na wpływ niższego wykształcenia matek na częstsze występowanie astmy oskrzelowej u dzieci, co związane może być z niekorzystnymi zachowaniami zdrowotnymi. Uczulenia na alergeny wziewne są charakterystyczne dla dzieci z rodzin o wysokim SES, co może być związane z częstszym wykonywaniem testów alergicznych w tej grupie.
Editorial
Authors: Santos Gildenir Carolino 
Published: October 2017

Temos o prazer de apresentar mais uma edição da ETD – Educação Temática Digital, contemplando o fascículo referente ao período de julho a dezembro de 2012, sob a temática “Perspectivas da educação multidisciplinar nos diversos campos de aprendizagem e formação”. Aqui publicamos 8 (oito) trabalhos da Seção Artigos; 8 (oito) trabalhos da Seção Pesquisa e 1 (um) trabalho da Seção Ensaio.
O paradigma emergente da educação: o professor como mediador de emoções
Authors: Arruda Marina Patricio 
Published: October 2017

Este ensaio tem como propósito refletir e atualizar o conceito de mediação que, minado por incertezas e opacidade, requer um novo exercício de compreensão, de modo a favorecer a renovação da nossa capacidade de agir e educar. Mais do que qualquer outra estratégia de ação, caberá ao professor assumir-se como mediador de emoções num mundo cujas relações sociais se apresentam cada vez mais complexas.
Editorial
Authors: Santos Gildenir Carolino 
Published: October 2017

Temos a satisfação de apresentar a primeira edição da ETD – Educação Temática Digital – na periodicidade quadrimestral, conforme dissemos no editorial da última edição (2012). A partir deste número, lançaremos anualmente três números temáticos, o que permitirá favorecer todos os trabalhos submetidos, que não precisarão aguardar a publicação de dois números para publicação no ano seguinte. Dessa forma, poderemos também seguir as recomendações para mudança de estratificação, de acordo com os procedimentos e as regras do Qualis/Capes.
O “novo” profissional da Rede Estadual do RS e as tecnologias na educação
Authors: Cimadevila Mely Paula Rabadan , Zuchetti Dinorá Tereza , Bassani Patrícia B. Scherer 
Published: October 2017

Educar na sociedade da informação não implica apenas na capacitação para o uso das tecnologias da informação e comunicação (TIC), mas envolve oportunizar o desenvolvimento de competências que permitam ao sujeito o efetivo envolvimento na sociedade permeada pelas tecnologias digitais. Entende-se que vivenciar novas formas de ensinar e aprender mediadas pelas TIC remete a um (re)pensar sobre os processos de formação de professores. A pesquisa O ‘novo’ profissional da rede estadual do RS e as tecnologias na educação, foi realizada em duas etapas: a primeira, de natureza quantitativa, foi responsável pela caracterização do profissional que ingressou na rede entre os anos de 2008 a 2010. A segunda, de natureza qualitativa, envolveu o estudo sobre o uso das tecnologias na atividade do professor, a partir da metodologia da autoconfrontação cruzada. Traçou-se o perfil do profissional da educação pública especialmente no que se refere à inserção no serviço público bem como a apropriação tecnológica de professores contratados que atuam em uma escola de Porto Alegre. O artigo destaca a relevância da metodologia da autoconfrontação como espaço de formação docente no que se refere às tecnologias em educação. A apropriação tecnológica existente não é decorrente da formação de graduação e nem é advinda da formação em serviço, apesar de o governo prever esta modalidade de qualificação através da política estadual de inclusão digital. São as experiências da vida diária que dão os parcos suportes para a atuação nesta modalidade de atividade.
Capoeira e temas transversais: avaliação de um blog didático para as aulas de educação física
Authors: Silva Luciana Maria Fernandes , Rufino Luiz Gustavo Bonatto , Darido Suraya Cristina 
Published: October 2017

A internet, atualmente, é uma significativa fonte de informação, sendo necessária a construção de sites educacionais resultantes de pesquisas científicas que fomentem reflexões pedagógicas. É preciso também fundamentar possibilidades de relações entre os temas transversais, grandes problemas da sociedade que devem ser contextualizados na escola, na prática educativa. Na Educação Física, a capoeira, parte integrante da cultura corporal de movimento, deve também ser abordada ao longo da prática pedagógica. Avaliou-se um blog desenvolvido para abordar os Temas Transversais e a Capoeira, levando-se em consideração a opinião de 23 professores participantes (12 mulheres e 11 homens, média de idade de 30 anos). Optou-se pela pesquisa qualitativa e análise de conteúdo a partir de um questionário desenvolvido para avaliar o blog. Dividiu-se a análise em duas categorias: apresentação do blog didático elaborado e análise dos resultados oriundos da avaliação dos participantes, sendo esta categoria dividida em 3 subcategorias: opiniões a respeito do design e da configuração do blog; interesse e motivação; considerações acerca dos temas transversais. Os resultados foram favoráveis quanto à coerência, à linguagem, a adequação do conteúdo ao tema e ao público-alvo, à visualização, à confiabilidade e o rigor conceitual do blog. Todos os participantes afirmaram ainda que utilizariam o conteúdo sugerido pelo blog para o desenvolvimento de suas aulas. A partir destes resultados, considera-se que o blog pode se tornar um material didático virtual, auxiliando os professores no processo de ensino-aprendizagem, contribuindo para o fazer didático da Educação Física escolar.
Acima de tudo, que a escola nos ensine. Em defesa da escola de surdos.
Authors: Lopes Maura Corcini , Veiga-Neto Alfredo 
Published: October 2017

A luta é condição da existência surda. Em maio de 2011, surdos de todo o Brasil saíram às ruas em defesa da escola de surdos. Foi um movimento sem precedentes em nosso país. Mobilizados, os intelectuais surdos redigiram uma carta ao Ministro da Educação. Em sintonia com seu tempo, eles afirmavam o direito à educação que atendesse às suas especificidades linguísticas e culturais. A mobilização em defesa da escola ocupou as ruas quando era iminente a ameaça do fechamento do Instituto Nacional de Educação de Surdos (INES). Na carta, os surdos concordavam que crianças e jovens com deficiência deveriam estar na escola, mas discordavam que a escola inclusiva fosse o único e melhor espaço para que os alunos aprendessem. Diante dos discursos pró-inclusão, eles afirmavam quererem conviver com os demais cidadãos brasileiros; porém, acima de tudo, queriam que a escola ensinasse. A partir dos Estudos Foucaultianos articulados aos Estudos Surdos em Educação, propõe-se analisar documentos e narrativas surdas em defesa da escola de surdos. Para tanto, parte-se do entendimento da surdez como experiência de subjetivação constituída, entre outros atravessamentos, pela escola e pelos exercícios de liberdade e de convivência surda entre surdos na escola.
After in defence of the school: an interview with jan masschelein and maarten simons
Authors: Carvalho Alexandre Filordi de , Aquino Julio Groppa 
Published: October 2017

The intent of the interview with the authors of In defence of the school was debating the reception of such book in the context of educational research in Brazil. On one hand, the very outreach of the idea of defending the school was inquired, taking into account the socio-historical context which still circumscribes the school in the functional register of State apparatus. On the other hand, and as a consequence, once again was called into question the book’s theoretical horizon, capable of substantiating the defence of the school as res publica. On both fronts, the interview ends up shedding some light to a triple problematization: a) the impasses as to what arguing in favor of formal education nowadays means; b) the consequences of school practice being thought only according to a theoretical-pedagogical dimension, as the authors maintain; c) the constant tension existing between the actualization of historical experiences in the multiplicity of school context and the presupposition of thinking of a general school model. Stemming from the interview, either the opponents or the proponents of Masschelein and Simons’ theses obtain new tools to rethink the ethico-political contours of In defence of the school.
Scaling up and kinetic model validation of Direct Black 22 degradation by immobilized Penicillium chrysogenum
Authors: Durruty Ignacio , González Jorge Froilán , Wolski Erika Alejandra 
Published: October 2017

Abstract
This research was undertaken to develop tools that facilitate the industrial application of an immobilized loofah–fungi system to degrade Direct Black 22 (DB22) azo dye. In laboratory-scale tests, the DB22, and loofah as support, were used. Assays without loofah were used as a free-cells control. The use of natural carriers to facilitate adhesion and growth of the fungi has shown favorable results. The degradation rate of immobilized cells increased twice as compared to free-cells control. At day 5 the decolorization was almost complete, while without loofah the total decolorization took more than 10 days. After 10 days, the extent of growth was nine times higher for the immobilized assays in comparison with the control flask. In subsequent experiments decolorization of DB22 was proven in a bench-scale reactor. A previously developed kinetic model was validated during the process. The model validation over free-cells assays gives an average normalized root mean squared error (ANRMSE) of 0.1659. Recalibration steps allowed prediction of the degradation with immobilized cells, resulting in an ANRMSE of 0.1891. A new calibration of the model during the scaling-up process yielded an ANRMSE of 0.1136 for DB22. The results presented encourage the use of this modeling tool in industrial scale facilities.