bluuebunny/crossref_metadata_2025_split huggingface dataset:
Historical Apprenticeship and the Historian’s Craft A Competency-Based Pathway
Authors: Berthon-Dumurgier Alexandre 
Published: April 2017

Abstract
A skills-based approach encourages us to see learning as a journey between the simplest and the most elaborate level of competence, which can be developed over a whole lifetime. Teachers in a middle school in Vitry-sur-Seine (to the south of Paris) have developed a competency-based approach to history that focuses on the key techniques of professional historians, including developing hypotheses by analyzing sets of documents and writing historical narratives. The link between “academic history” and “school history” strengthens students’ learning.
From Didactics to the Epistemology of History A Shared Reflexivity
Authors: Girault Bénédicte 
Published: April 2017

Abstract
Behind the complex issue of the relationship between the professionalization of teacher training and the spaces where academic and disciplinary knowledge is produced lie questions about the very nature of historical research. This paper suggests that the reflexive practices of professional historians and of those who teach history can be a meeting ground for scientific, didactic, and pedagogical questions that concern secondary schools and universities alike. In terms of the training of future history teachers, this implies combining the acquisition of historical knowledge and a personal, hands-on experience of researching and writing history from the very beginning of the learning process.
E-story, or the New Hollywood Myth
Authors: Moatti Claudia 
Published: April 2017

Abstract
David Armitage and Jo Guldi’s History Manifesto has sparked an important debate in the United States. This article criticizes three specific aspects of their work. First, it takes issue with their description of a “moral crisis” of history, which they postulate without any discussion of serious epistemological and political issues. Second, it calls into question their enthusiasm for technological solutions, an ideological stance highlighted by their call for a return to long-term history and large-scale syntheses relying on the crunching of vast quantities of digitized data. Finally, it interrogates their conception of the utility of history, a notion that reveals serious confusion between research, teaching, and popularization and supports their unquestioning acceptance of the direction taken by institutions of higher learning. Although the scientism and positivism expressed in their manifesto illuminate their lack of attention to, and perhaps simply awareness of, the slow construction and transmission of accumulated knowledge, they do reflect the prevailing intellectual nonchalance and philosophical regression. The authors’ vision would see the replacement of “history” by “e-story,” the dissolution of historicity and scholarly critique and their substitution by techno-chronology and marketing.
Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy
Authors: Lin Congcong , Wong Blenda Chi Kwan , Chen Hubiao , Bian Zhaoxiang , Zhang Ge , Zhang Xue , Kashif Riaz Muhammad , Tyagi Deependra , Lin Ge , Zhang Yanbo , Wang Jinjin , Lu Aiping , Yang Zhijun 
Published: April 2017

AbstractAntibody-decorated liposomes can facilitate the precise delivery of chemotherapeutic drugs to the lung by targeting a recognition factor present on the surface of lung tumor cells. Carbonic anhydrase IX (CA IX) is an enzyme expressed on the surface of lung cancer cells with a restricted expression in normal lungs. Here, we explored the utility of anti-carbonic anhydrase IX (CA IX) antibody, conjugated to the surface of triptolide (TPL)-loaded liposomes (CA IX-TPL-Lips), to promote the therapeutic effects for lung cancer via pulmonary administration. It was found that the CA IX-TPL-Lips significantly improved the cellular uptake efficiency in both CA IX-positive human non-small cell lung cancer cells (A549) and A549 tumor spheroids, resulting in the efficient cell killing compared with free TPL and non-targeted TPL-Lips. In vivo, CA IX-Lips via pulmonary delivery showed specificity and a sustained release property resided up to 96 h in the lung, both of which improved the efficiency of TPL formulations in restraining tumor growth and significantly prolonged the lifespan of mice with orthotopic lung tumors. The results suggest that CA IX-decorated liposomes can potentially be used as an effective therapeutic strategy for lung cancer.
A genome-wide SNP-based genetic map and QTL mapping for agronomic traits in Chinese cabbage
Authors: Huang Li , Yang Yafei , Zhang Fang , Cao Jiashu 
Published: April 2017

AbstractThe aim of this work was to construct a high-resolution genetic map for the dissection of complex morphological and agronomic traits in Chinese cabbage (Brassica rapa L. syn. B. campestris). Chinese cabbage, an economically important vegetable, is a good model plant for studies on the evolution of morphologic variation. Herein, two high-generation inbred Chinese cabbage lines, ‘Huangxiaoza’ and ‘Bqq094-11’, were crossed. Then restriction-site-associated DNA sequencing (RAD-seq) was performed on the parents and 120 F2 individuals. A genetic map containing 711 bins representing 3985 single nucleotide polymorphism (SNP) markers was constructed. By using WinQTL with composite interval mapping (CIM) and mixed-model based composite interval mapping (MCIM) analysis via QTLNetwork, quantitative trait loci (QTL) linked to 16 genetic traits related to plant size, color and leaf characteristics were mapped to 10 linkage groups. The high density genetic map and QTL identified for morphological and agronomic traits lay the groundwork for functional gene mapping, map-based cloning and marker-assisted selection (MAS) in Chinese cabbage.
Zero birefringence films of pullulan ester derivatives
Authors: Danjo Takahiro , Enomoto Yukiko , Shimada Hikaru , Nobukawa Shogo , Yamaguchi Masayuki , Iwata Tadahisa 
Published: April 2017

AbstractHigh-performance films with almost zero-birefringence and zero-wavelength dispersion were succeeded to prepare from pullulan esters derivatives (PLEs) without any additives. Optical transmittance analysis, birefringence measurement of PLE cast film and hot stretched films, and infrared dichroism analysis were conducted to characterize optical properties of PLE films comparing with cellulose triacetate which is commercially used as low-birefringence in optical devices. The aims of this study, characterization of optical properties of pullulan esters, can develop a deep understanding of the fundamental knowing and applicability of polysaccharides. Accordingly, authors believe this paper will open the gate for researches in the application of polysaccharides.
Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation
Authors: Sandén Emma , Dyberg Cecilia , Krona Cecilia , Gallo-Oller Gabriel , Olsen Thale Kristin , Enríquez Pérez Julio , Wickström Malin , Estekizadeh Atosa , Kool Marcel , Visse Edward , Ekström Tomas J. , Siesjö Peter , Johnsen John Inge , Darabi Anna 
Published: April 2017

AbstractMedulloblastomas comprise a heterogeneous group of tumours and can be subdivided into four molecular subgroups (WNT, SHH, Group 3 and Group 4) with distinct prognosis, biological behaviour and implications for targeted therapies. Few experimental models exist of the aggressive and poorly characterized Group 3 tumours. In order to establish a reproducible transplantable Group 3 medulloblastoma model for preclinical therapeutic studies, we acquired a patient-derived tumour sphere culture and inoculated low-passage spheres into the cerebellums of NOD-scidmice. Mice developed symptoms of brain tumours with a latency of 17–18 weeks. Neurosphere cultures were re-established and serially transplanted for 3 generations, with a negative correlation between tumour latency and numbers of injected cells. Xenografts replicated the phenotype of the primary tumour, including high degree of clustering in DNA methylation analysis, high proliferation, expression of tumour markers,MYCamplification and elevatedMYCexpression, and sensitivity to theMYCinhibitor JQ1. Xenografts maintained maintained expression of tumour-derived VEGFA and stromal-derived COX-2. VEGFA, COX-2 and c-Myc are highly expressed in Group 3 compared to other medulloblastoma subgroups, suggesting that these molecules are relevant therapeutic targets in Group 3 medulloblastoma.
Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent
Authors: Cruz-Roa Angel , Gilmore Hannah , Basavanhally Ajay , Feldman Michael , Ganesan Shridar , Shih Natalie N.C. , Tomaszewski John , González Fabio A. , Madabhushi Anant 
Published: April 2017

AbstractWith the increasing ability to routinely and rapidly digitize whole slide images with slide scanners, there has been interest in developing computerized image analysis algorithms for automated detection of disease extent from digital pathology images. The manual identification of presence and extent of breast cancer by a pathologist is critical for patient management for tumor staging and assessing treatment response. However, this process is tedious and subject to inter- and intra-reader variability. For computerized methods to be useful as decision support tools, they need to be resilient to data acquired from different sources, different staining and cutting protocols and different scanners. The objective of this study was to evaluate the accuracy and robustness of a deep learning-based method to automatically identify the extent of invasive tumor on digitized images. Here, we present a new method that employs a convolutional neural network for detecting presence of invasive tumor on whole slide images. Our approach involves training the classifier on nearly 400 exemplars from multiple different sites, and scanners, and then independently validating on almost 200 cases from The Cancer Genome Atlas. Our approach yielded a Dice coefficient of 75.86%, a positive predictive value of 71.62% and a negative predictive value of 96.77% in terms of pixel-by-pixel evaluation compared to manually annotated regions of invasive ductal carcinoma.
TmCactin plays an important role in Gram-negative and -positive bacterial infection by regulating expression of 7 AMP genes in Tenebrio molitor
Authors: Jo Yong Hun , Kim Yu Jung , Park Ki Beom , Seong Jeong Hwan , Kim Soo Gon , Park Soyi , Noh Mi Young , Lee Yong Seok , Han Yeon Soo 
Published: April 2017

AbstractCactin was originally identified as an interactor of the Drosophila IκB factor Cactus and shown to play a role in controlling embryonic polarity and regulating the NF-κB signaling pathway. While subsequent studies have identified the roles for Cactin in the mammalian immune response, the immune function of Cactin in insects has not been described yet. Here, we identified a Cactin gene from the mealworm beetle, Tenebrio molitor (TmCactin) and characterized its functional role in innate immunity. TmCactin was highly expressed in prepupa to last instar stages, and its expression was high in the integument and Malpighian tubules of last instar larvae and adults. TmCactin was induced in larvae after infection with different pathogens and detectable within 3 hours of infection. The highest levels of TmCactin expression were detected at 9 hours post infection. TmCactin RNAi significantly decreased the survival rates of larvae after challenge with Escherichia coli and Staphylococcus aureus, but had no significant effect after challenge with Candida albicans. Furthermore, TmCactin RNAi significantly reduced the expression of seven antimicrobial peptide genes (AMPs) after bacterial challenge. Our results suggest that TmCactin may serve as an important regulator of innate immunity, mediating AMP responses against both Gram-positive and Gram-negative bacteria in T. molitor.
Host Determinants of Expression of the Helicobacter pylori BabA Adhesin
Authors: Kable Mary E. , Hansen Lori M. , Styer Cathy M. , Deck Samuel L. , Rakhimova Olena , Shevtsova Anna , Eaton Kathryn A. , Martin Miriam E. , Gideonsson Pär , Borén Thomas , Solnick Jay V. 
Published: April 2017

AbstractExpression of the Helicobacter pylori blood group antigen binding adhesin A (BabA) is more common in strains isolated from patients with peptic ulcer disease or gastric cancer, rather than asymptomatic colonization. Here we used mouse models to examine host determinants that affect H. pylori BabA expression. BabA expression was lost by phase variation as frequently in WT mice as in RAG2−/− mice that do not have functional B or T cells, and in MyD88−/−, TLR2−/− and TLR4−/− mice that are defective in toll like receptor signaling. The presence of other bacteria had no effect on BabA expression as shown by infection of germ free mice. Moreover, loss of BabA expression was not dependent on Leb expression or the capacity of BabA to bind Leb. Surprisingly, gender was the host determinant most associated with loss of BabA expression, which was maintained to a greater extent in male mice and was associated with greater bacterial load. These results suggest the possibility that loss of BabA expression is not driven by adaptive immunity or toll-like receptor signaling, and that BabA may have other, unrecognized functions in addition to serving as an adhesin that binds Leb.
A pathway linking reward circuitry, impulsive sensation-seeking and risky decision-making in young adults: identifying neural markers for new interventions
Authors: Chase H W , Fournier J C , Bertocci M A , Greenberg T , Aslam H , Stiffler R , Lockovich J , Graur S , Bebko G , Forbes E E , Phillips M L 
Published: April 2017

AbstractHigh trait impulsive sensation seeking (ISS) is common in 18–25-year olds, and is associated with risky decision-making and deleterious outcomes. We examined relationships among: activity in reward regions previously associated with ISS during an ISS-relevant context, uncertain reward expectancy (RE), using fMRI; ISS impulsivity and sensation-seeking subcomponents; and risky decision-making in 100, transdiagnostically recruited 18–25-year olds. ISS, anhedonia, anxiety, depression and mania were measured using self-report scales; clinician-administered scales also assessed the latter four. A post-scan risky decision-making task measured ‘risky’ (possible win/loss/mixed/neutral) fMRI-task versus ‘sure thing’ stimuli. ‘Bias’ reflected risky over safe choices. Uncertain RE-related activity in left ventrolateral prefrontal cortex and bilateral ventral striatum was positively associated with an ISS composite score, comprising impulsivity and sensation-seeking–fun-seeking subcomponents (ISSc;P⩽0.001). Bias positively associated with sensation seeking–experience seeking (ES;P=0.003). This relationship was moderated by ISSc (P=0.009): it was evident only in high ISSc individuals. Whole-brain analyses showed a positive relationship between: uncertain RE-related left ventrolateral prefrontal cortical activity and ISSc; uncertain RE-related visual attention and motor preparation neural network activity and ES; and uncertain RE-related dorsal anterior cingulate cortical activity and bias, specifically in high ISSc participants (all ps<0.05, peak-level, family-wise error corrected). We identify an indirect pathway linking greater levels of uncertain RE-related activity in reward, visual attention and motor networks with greater risky decision-making, via positive relationships with impulsivity, fun seeking and ES. These objective neural markers of high ISS can guide new treatment developments for young adults with high levels of this debilitating personality trait.
Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women
Authors: Bethlehem R A I , Lombardo M V , Lai M-C , Auyeung B , Crockford S K , Deakin J , Soubramanian S , Sule A , Kundu P , Voon V , Baron-Cohen S 
Published: April 2017

AbstractOxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male biased and often constrained by task-based inferences. Here, we investigate the impact of oxytocin on resting-state connectivity between subcortical and cortical networks in women. We collected resting-state functional magnetic resonance imaging (fMRI) data on 26 typically developing women 40 min following intranasal oxytocin administration using a double-blind placebo-controlled crossover design. Independent components analysis (ICA) was applied to examine connectivity between networks. An independent analysis of oxytocin receptor (OXTR) gene expression in human subcortical and cortical areas was carried out to determine plausibility of direct oxytocin effects on OXTR. In women, OXTR was highly expressed in striatal and other subcortical regions, but showed modest expression in cortical areas. Oxytocin increased connectivity between corticostriatal circuitry typically involved in reward, emotion, social communication, language and pain processing. This effect was 1.39 standard deviations above the null effect of no difference between oxytocin and placebo. This oxytocin-related effect on corticostriatal connectivity covaried with autistic traits, such that oxytocin-related increase in connectivity was stronger in individuals with higher autistic traits. In sum, oxytocin strengthened corticostriatal connectivity in women, particularly with cortical networks that are involved in social-communicative, motivational and affective processes. This effect may be important for future work on neurological and psychiatric conditions (for example, autism), particularly through highlighting how oxytocin may operate differently for subsets of individuals.
Mapping the Early Language Environment Using All-Day Recordings and Automated Analysis
Authors: Gilkerson Jill , Richards Jeffrey A. , Warren Steven F. , Montgomery Judith K. , Greenwood Charles R. , Kimbrough Oller D. , Hansen John H. L. , Paul Terrance D. 
Published: April 2017

Purpose
This research provided a first-generation standardization of automated language environment estimates, validated these estimates against standard language assessments, and extended on previous research reporting language behavior differences across socioeconomic groups.

Method
Typically developing children between 2 to 48 months of age completed monthly, daylong recordings in their natural language environments over a span of approximately 6–38 months. The resulting data set contained 3,213 12-hr recordings automatically analyzed by using the Language Environment Analysis (LENA) System to generate estimates of (a) the number of adult words in the child's environment, (b) the amount of caregiver–child interaction, and (c) the frequency of child vocal output.

Results
Child vocalization frequency and turn-taking increased with age, whereas adult word counts were age independent after early infancy. Child vocalization and conversational turn estimates predicted 7%–16% of the variance observed in child language assessment scores. Lower socioeconomic status (SES) children produced fewer vocalizations, engaged in fewer adult–child interactions, and were exposed to fewer daily adult words compared with their higher socioeconomic status peers, but within-group variability was high.

Conclusions
The results offer new insight into the landscape of the early language environment, with clinical implications for identification of children at-risk for impoverished language environments.
Randomized Controlled Trial in Clinical Settings to Evaluate Effectiveness of Coping Skills Education Used With Progressive Tinnitus Management
Authors: Henry James A. , Thielman Emily J. , Zaugg Tara L. , Kaelin Christine , Schmidt Caroline J. , Griest Susan , McMillan Garnett P. , Myers Paula , Rivera Izel , Baldwin Robert , Carlson Kathleen 
Published: April 2017

PurposeThis randomized controlled trial evaluated, within clinical settings, the effectiveness of coping skills education that is provided with progressive tinnitus management (PTM).MethodAt 2 Veterans Affairs medical centers,N= 300 veterans were randomized to either PTM intervention or 6-month wait-list control. The PTM intervention involved 5 group workshops: 2 led by an audiologist (teaching how to use sound as therapy) and 3 by a psychologist (teaching coping skills derived from cognitive behavioral therapy). It was hypothesized that PTM would be more effective than wait-list control in reducing functional effects of tinnitus and that there would be no differences in effectiveness between sites.ResultsAt both sites, a statistically significant improvement in mean Tinnitus Functional Index scores was seen at 6 months for the PTM group. Combined data across sites revealed a statistically significant improvement in Tinnitus Functional Index relative to wait-list control. The effect size for PTM using the Tinnitus Functional Index was 0.36 (small).ConclusionsResults suggest that PTM is effective at reducing tinnitus-related functional distress in clinical settings. Although effect sizes were small, they provide evidence of clinical effectiveness of PTM in the absence of stringent research-related inclusion criteria and with a relatively small number of sessions of cognitive behavioral therapy.
University Students' Perceptions of a Person Who Clutters With or Without Video Education
Authors: Blanchet Paul G. , Farrell Lindsey M. , Snyder Greg 
Published: April 2017

Purpose
The purpose of this study was to examine the effects of video education about cluttering on students' perceptions of a person who clutters.

Method
A total of 193 undergraduate students served as participants. Ninety-five students were provided with a written definition of cluttering, while 98 were also provided with video education about cluttering. Students then rated a person who clutters on speech and personality scales.

Results
Results yielded significant group differences in ratings of intelligibility, speech rate, ease of listening, and competence. Respondents who viewed the educational video rated a person who clutters significantly more negatively along these dimensions than respondents who read a definition only. However, participants who did not view the video reported knowing significantly more people who clutter.

Conclusion
Findings suggest that this particular form of video education might provide students with “realistic” exposure to cluttering. Further research is needed to assess effects of exposure to and interaction with a person who clutters on perceptions of cluttering. Implications include the impact of prior exposure to those who clutter, as well as potential confusion between cluttering and “fast speech.” These factors might have influenced identification rates of individuals who clutter, which could have affected the results.
Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis
Authors: Li Bin , Ding Siyuan , Feng Ningguo , Mooney Nancie , Ooi Yaw Shin , Ren Lili , Diep Jonathan , Kelly Marcus R. , Yasukawa Linda L. , Patton John T. , Yamazaki Hiroyuki , Shirao Tomoaki , Jackson Peter K. , Greenberg Harry B. 
Published: April 2017

Significance
Many clinically significant human viral and bacterial pathogens use dynamin-dependent endocytosis to initiate infection or deliver toxin into host cells. Owing to the complex nature of this cellular process, the molecular mechanisms that regulate this pathway remain to be fully elucidated. Here, we use rotavirus (RV) as a model and identify drebrin as a regulatory protein that restricts the cell entry of multiple viruses. We demonstrate that genetic depletion or chemical inhibition of drebrin leads to enhanced RV infection in vitro and increased diarrhea incidence and virus shedding in vivo. Our current study provides insights into endocytosis regulation in general and highlights the potential broad application of blocking drebrin to augment the uptake of viruses and other dynamin-mediated cargo.