bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Claims Data Algorithms Identify the Physician of Record?
Authors: DuGoff Eva H. , Walden Emily , Ronk Katie , Palta Mari , Smith Maureen 
Published: March 2017

Background:
Claims-based algorithms based on administrative claims data are frequently used to identify an individual’s primary care physician (PCP). The validity of these algorithms in the US Medicare population has not been assessed.

Objective:
To determine the agreement of the PCP identified by claims algorithms with the PCP of record in electronic health record data.

Data:
Electronic health record and Medicare claims data from older adults with diabetes.

Subjects:
Medicare fee-for-service beneficiaries with diabetes (N=3658) ages 65 years and older as of January 1, 2008, and medically housed at a large academic health system.

Measures:
Assignment algorithms based on the plurality and majority of visits and tie breakers determined by either last visit, cost, or time from first to last visit.

Results:
The study sample included 15,624 patient-years from 3658 older adults with diabetes. Agreement was higher for algorithms based on primary care visits (range, 78.0% for majority match without a tie breaker to 85.9% for majority match with the longest time from first to last visit) than for claims to all visits (range, 25.4% for majority match without a tie breaker to 63.3% for majority match with the amount billed tie breaker). Percent agreement was lower for nonwhite individuals, those enrolled in Medicaid, individuals experiencing a PCP change, and those with >10 physician visits.

Conclusions:
Researchers may be more likely to identify a patient’s PCP when focusing on primary care visits only; however, these algorithms perform less well among vulnerable populations and those experiencing fragmented care.
Application of telepractice for head and neck cancer management: a review of speech language pathology service models
Authors: Ward Elizabeth C. , Wall Laurelie R. , Burns Clare L. , Cartmill Bena , Hill Anne J. 
Published: March 2017

Purpose of review
Head and neck cancer (HNC) is a complex and heterogeneous disease, requiring specialist intervention from a multidisciplinary team including speech language pathology (SLP). Unfortunately, multiple patient and service-related challenges exist which currently limit equitable access to SLP support for all individuals. This review highlights the existing evidence for different telepractice models designed to help patients and services optimize management of swallowing and communication disorders arising from HNC.

Recent findings
Emerging evidence exists for using computerized screening to enhance the identification of treatment-related toxicities and assist referrals to services, including SLP. Asynchronous telepractice applications are being used to assist delivery of intensive home-based dysphagia therapy, whereas videoconferencing can offer a feasible and effective method to support ongoing management for patients with limited access to local specialist SLP services. Patient and clinician satisfaction with all models has been high.

Summary
SLP services can be redesigned to incorporate a range of telepractice models to optimize clinical care at different stages of the HNC survivorship pathway. Early evidence supports telepractice can improve patient access to services, enhance outcomes, and optimize health service efficiency; however, further systematic research is needed into these models, particularly relating to large-scale implementation and costs/economic analyses.
Pediatric enteric neuropathies: diagnosis and current management
Authors: Westfal Maggie L. , Goldstein Allan M. 
Published: March 2017

Purpose of review
Neurointestinal diseases are increasingly recognized as causes of significant gastrointestinal morbidity in children. This review highlights the most common pediatric enteric neuropathies and their diagnosis and management, emphasizing insights and discoveries from the most recent literature available.

Recent findings
The embryologic and histopathologic causes of enteric neuropathies are varied. They range from congenital aganglionosis in Hirschsprung disease, to autoimmune-mediated loss of neuronal subtypes in esophageal achalasia and Chagas disease, to degenerative neuropathies in some cases of chronic intestinal pseudo-obstruction and gastroparesis. Increased awareness of the clinical presentation and diagnostic evaluation of these conditions is essential as it allows for earlier initiation of treatment and improved outcomes. Most current therapies, which include medical management, neurostimulation, and operative intervention, aim to minimize the symptoms caused by these conditions. The evidence base for many of these treatments in children is poor, and multiinstitutional prospective studies are needed. An innovative therapy on the horizon involves using neuronal stem cell transplantation to treat the underlying disorder by replacing the missing or damaged neurons in these diseases.

Summary
Although recent advances in basic and clinical neurogastroenterology have significantly improved our awareness and understanding of enteric neuropathies, the efficacy of current treatment approaches is limited. The development of novel therapies, including pharmacologic modulators of neurointestinal function, neurostimulation to enhance gut motility, and neuronal cell-based therapies, is essential to improve the long-term outcomes in children with these disorders.
An In Vitro Assessment of the Efficacy of Various IV Cannulas for the Rapid IV Fluid Administration
Authors: Kamata Mineto , Walia Hina , Hakim Mumin , Tumin Dmitry , Tobias Joseph D. 
Published: March 2017

Objectives:
The current study prospectively evaluates the administration of fluid through commonly used vascular cannulas of various length and diameter.

Design:
Observational, in vitro experiment.

Setting:
Not applicable.

Subjects:
No human subjects.

Interventions:
None.

Measurements and Main Results:
Fluid (500 mL) was administered via gravity flow and with pressure assistance (pressure bag set at 300 mm Hg) through various vascular cannulas including peripheral IV catheters (22 gauge, 1 inch; 20 gauge, 1.16 and 1.88 inch; and 18 gauge, 1.16 and 1.88 inch), 3-Fr central line lumens (lengths 50, 80, and 120 mm), and a 4-Fr, 10 cm Micropuncture catheter (Cook Medical, Bloomington, IN). During gravity flow, drain time decreased by approximately 50% when moving from a 22 to 20 to 18 gauge cannula and increased by approximately 20% as the catheter length increased from 50 to 80 to 120 cm. Flow rates were highest with the Micropuncture catheter, which achieved a drain time of 2.7 minutes for the 500 mL bag when infused with pressure assistance.

Conclusions:
In general, the delivery of crystalloid solutions through commonly used vascular cannulas was fastest with larger diameter and shorter length cannulas. Pressure-assisted flow was able to partially compensate for the increased resistance with smaller and longer catheters. The unique design of the tip of the Micropuncture catheter compensated for the increased length and allowed for rapid fluid delivery. This design may compensate for the increased length when longer catheters are needed for ultrasound-guided placement.
TheDrosophilaEmbryo at Single Cell Transcriptome Resolution
Authors: Karaiskos Nikos , Wahle Philipp , Alles Jonathan , Boltengagen Anastasiya , Ayoub Salah , Kipar Claudia , Kocks Christine , Rajewsky Nikolaus , Zinzen Robert P. 
Published: March 2017

ABSTRACTDrosophilais a premier model system for understanding the molecular mechanisms of development. By the onset of morphogenesis, ~6000 cells express distinct gene combinations according to embryonic position. Despite extensive mRNAin situscreens, combinatorial gene expression within individual cells is largely unknown. Therefore, it is difficult to comprehensively identify the coding and non-coding transcripts that drive patterning and to decipher the molecular basis of cellular identity. Here, we single-cell sequence precisely staged embryos, measuring >3100 genes per cell. We produce a ‘transcriptomic blueprint’ of development – a virtual embryo where 3D locations of sequenced cells are confidently identified. Our “Drosophila-Virtual-Expression-eXplorer” performs virtual in situ hybridizations and computes expression gradients. Using DVEX, we predict spatial expression and discover patterned lncRNAs. DEVX is sensitive enough to detect subtle evolutionary changes in expression patterns betweenDrosophilaspecies. We believe DVEX is a prototype for powerful single cell studies in complex tissues.
Methods to Reduce Sea Turtle Interactions in the Atlantic Canadian Pelagic Long Line Fleet
Authors: Sherker Zachary T. 
Published: March 2017

AbstractThis project investigates the role of fisheries management in the conservation of loggerhead (Caretta caretta) and leatherback sea turtles (Dermochelys coriacea),both of which are currently listed as vulnerable by the IUCN (International Union for Conservation of Nature). These species migrate from nesting grounds in South America to feed on gelatinous zooplankton (jellyfish) in the North Atlantic off the coast of the United States and Canada. The seasonal foraging grounds of sea turtles heavily overlap with areas of high fishing effort for the longline tuna and swordfish fleet, a fishery that has significantly high rates of sea turtle incidents. The dynamic nature of sea turtle foraging patterns renders static spatio-temporal fishing area closures ineffective. Rather, turtle by-catch mitigation requires small-scale, event-triggered closures and decentralized management to reduce incidents while minimizing the negative socio-economic impact of area closures on fishermen. A number of methods that increase fishing selectivity have been implemented in other commercial fisheries around the globe and are suggested for the Atlantic Canadian fleet moving forward.
Efficacy of land use designation in protecting habitat in the miombo woodlands: Insights from Tanzania
Authors: Lobora Alex L. , Nahonyo Cuthbert L. , Munishi Linus K. , Caro Tim , Foley Charles , Beale Colin M. 
Published: March 2017

AbstractLoss of natural landscapes surrounding major conservation areas compromise their future and threaten long-term conservation. We evaluate the effectiveness of fully and lesser protected areas within Katavi-Rukwa and Ruaha-Rungwa ecosystems in south-western Tanzania to protecting natural landscapes within their boundaries over the past four decades. Using a time series of Landsat satellite imageries of September 1972, July 1990 and September 2015, we assess the extent to which natural habitat has been lost within and around these areas mainly through anthropogenic activities. We also test the viability of the remaining natural habitat to provide connectivity between the two ecosystems. Our analysis reveals that while fully protected areas remained intact over the past four decades, lesser protected areas lost a combined total area of about 5,984 km2during that period which is about 17.5% of habitat available in 1972. We also find that about 3,380 km2of natural habitat is still available for connectivity between the two ecosystems through Piti East and Rungwa South Open Areas. We recommend relevant authorities to establish conservation friendly village land use plans in all villages surrounding and between the two ecosystems to ensure long-term conservation of these ecosystems.
Communicability systematically explains transmission speed in a cortical macro-connectome
Authors: Shimono Masanori , Hatano Naomichi 
Published: March 2017

AbstractGlobal dynamics in the brain can be captured using fMRI, MEG, or electrocorticography (ECoG), but models are often restricted by anatomical constraints. Complementary single-/multi-unit recordings have described local fast temporal dynamics. However, because of anatomical constraints, global fast temporal dynamics remain incompletely understood. Therefore, we compared temporal aspects of cross-area propagations of single-unit recordings and ECoG, and investigated their anatomical bases. First, we demonstrated how both evoked and spontaneous ECoGs can accurately predict latencies of single-unit recordings. Next, we estimated the propagation velocity (1.0–1.5 m/s) from brain-wide data and found that it was fairly stable among different conscious levels. We also found that the anatomical topology strongly predicted the latencies. Finally,Communicability,a novel graph-theoretic measure, could systematically capture the balance between shorter or longer pathways. These results demonstrate that macro-connectomic perspective is essential for evaluating detailed temporal dynamics in the brain.Author SummaryThis study produced four main findings: First, we demonstrated that ECoG signals could predict the timing of evoked electrical spikes of neurons elicited by visual stimuli. Second, we showed that spontaneous ECoG recorded under a blindfold condition (without any stimuli) could also predict the timing of visually evoked neuronal spikes. We also clarified that performance predictions from blindfold data are essentially supported by the constraints of structural paths. Third, we quantified the propagation velocity (conductance velocity) as 1.0–1.5 m/s, and found that the velocity was stable among different conscious levels. Fourth,Communicabilitysuccessfully characterized the relative contributions of shorter and longer paths. This study represents an important contribution to the theoretical understanding of the brain in terms of connectomics, dynamical propagations, and multi-scale architectures.
The maternal environment interacts with genetic variation in regulating seed dormancy inArabidopsis thaliana
Authors: Kerdaffrec Envel , Nordborg Magnus 
Published: March 2017

AbstractSeed dormancy is a complex adaptive trait that controls the timing of seed germination, one of the major fitness components in many plant species. Despite being highly heritable, seed dormancy is extremely plastic and influenced by a wide range of environmental cues. Here, using a set of 92Arabidopsis thalianalines from Sweden, we investigate the effect of seed maturation temperature on dormancy variation at the population level. The response to temperature differs dramatically between lines, demonstrating that genotype and the maternal environment interact in controlling the trait. By performing a genome-wide association study (GWAS), we identified several candidate genes that could account for this plasticity, two of which are involved in the photoinduction of germination. Altogether, our results provide insight into both the molecular mechanisms and the evolution of dormancy plasticity, and can serve to improve our understanding of environmentally dependent life-history transitions.HighlightThe effect of low seed-maturation temperatures on seed dormancy is highly variable inArabidopsis thalianaaccessions from Sweden, denoting strong genotype-environment interactions, and a genome-wide association study identified compelling candidates that could account for this plasticity.
Deciphering the combinatorial influence of diet and the microbiota on experimental colitis
Authors: Llewellyn Sean R. , Britton Graham J. , Contijoch Eduardo J. , Mortha Arthur , Colombel Jean-Frederic , Grinspan Ari , Clemente Jose C. , Merad Miriam , Faith Jeremiah J. 
Published: March 2017

AbstractBackground & AimsThe complex interactions between diet and the microbiota that influence mucosal inflammation and inflammatory bowel disease are poorly understood. Experimental colitis models provide the opportunity to control and systematically perturb diet and the microbiota in parallel to quantify the contributions between multiple dietary ingredients and the microbiota on host physiology and colitis.MethodsTo examine the interplay of diet and the gut microbiota on host health and colitis, we fed over 40 different diets with varied macronutrient sources and concentrations to specific pathogen free or germ free mice either in the context of healthy, unchallenged animals or colitis models (dextran sodium sulfate (DSS) and T cell transfer).ResultsDiet influenced physiology in both health and colitis across all models, with the concentration of protein and psyllium fiber having the most profound effects. Increasing dietary protein elevated gut microbial density and worsened DSS colitis severity. Depleting gut microbial density by using germ-free animals or antibiotics negated the effect of a high protein diet. Psyllium fiber influenced host physiology and attenuated colitis severity through microbiota-dependent and microbiota-independent mechanisms. Combinatorial perturbations to dietary protein and psyllium fiber in parallel explain most variation in gut microbial density, intestinal permeability, and DSS colitis severity, and changes in one ingredient can be offset by changes in the other.ConclusionsOur results demonstrate the importance of examining complex mixtures of nutrients to understand the role of diet in intestinal inflammation.
Natural disasters, entrepreneurship, and creation after destruction
Authors: Monllor Javier , Murphy Patrick J. 
Published: March 2017

Purpose
The purpose of this paper is to contribute a deeper understanding of how natural disasters influence entrepreneurial intentionality as an important antecedent of entrepreneurial intention. It reviews the conceptual and operational backgrounds of natural disaster research and entrepreneurship theories and formulates a distinctive conceptual approach to entrepreneurial intentions in natural disaster settings.

Design/methodology/approach
An exhaustive review of research articles published in peer-reviewed entrepreneurship journals is provided and focuses on entrepreneurship, natural disasters, and entrepreneurial opportunities.

Findings
Six propositions about the influence of natural disasters on entrepreneurial intentions in ways that are distinct to the specific circumstances of post-disaster environments.

Research limitations/implications
The paper’s findings serve as a useful foundation for future research of post-disaster entrepreneurial behavior. The propositions highlight the relationship between opportunities, self-efficacy, feasibility, desirability, fear of failure, and resilience that complement macro-level research with micro-level antecedents. Implications entail new methodological avenues for future studies of humanitarian and post-disaster entrepreneurial activities.

Practical implications
This paper suggests ways in which public policy and educational, state and community programs can be designed and executed so that entrepreneurial intentions are developed and entrepreneurial action is not hindered. Moreover, it clarifies several ways to achieve more effective action (or inaction) to serve those affected by natural disasters and minimize disaffection.

Originality/value
The study illustrates that natural disasters can and do create opportunities for entrepreneurial behavior even as they generate powerful and sweeping negative effects on socioeconomic systems. Its unique approach explores individual-level variables concerning intent and motivation that drive entrepreneurial decisions in disaster contexts.
Critical observations on the statistical process control implementation in the UK food industry
Authors: Abdul Halim Lim Sarina , Antony Jiju , He Zhen , Arshed Norin 
Published: March 2017

PurposeStatistical process control (SPC) is widely applied for control and improve processes in manufacturing, but very few studies have reported on the successful application of SPC in the food industry, in particular. The purpose of this paper is to critically assess the status of SPC in the UK food manufacturing industry and to suggest future research avenues.Design/methodology/approachA research project was carried out in the UK food manufacturing sector through questionnaires. The results of the study were analysed using descriptive statistics and statistical tests to be applied in the hypothesis testing.FindingsFindings revealed that 45 per cent of the respondents are SPC users andx¯-R andx¯-S charts are the most commonly applied SPC charts in this industry. It was determined that top management commitment is the most critical factor, while lack of SPC training is the most alarming challenge, and lack of awareness of SPC and its benefits are the main reasons for the food companies not implementing SPC.Research limitations/implicationsThe study considered only the food manufacturing companies. Future research could be addressed toward the food service and food supply chain.Practical implicationsThe paper provides information to food companies in the UK on most common practiced and important quality tools, SPC charts and critical success factors in the food industry. Moreover, the most challenging factors of SPC implementation in the food industry are presented.Originality/valueThis study depicted the current state of SPC practices in the food industry and the process performance in SPC and non-SPC companies is compared.
An assessment of national healthcare service delivery: a Ghanaian illustration
Authors: Boakye Kwabena G. , Blankson Charles , Prybutok Victor R. , Qin Hong 
Published: March 2017

Purpose
The purpose of this paper is to propose and test a healthcare framework of service quality, perceived value, and satisfaction in Ghana. More specifically, this study investigates the role and effect of service quality on patient satisfaction and perceived value in Ghana’s healthcare delivery.

Design/methodology/approach
Data were gathered through surveys administered to 113 healthcare patients in Ghana. partial least square-structural equation modeling analysis was used to empirically test the research model.

Findings
Results show healthcare quality significantly influences satisfaction and perceived value of healthcare delivery. Additionally, perceived value’s impact on satisfaction and behavioral intention shows that increasing perceived benefits while reducing perceived costs leads to repeat behavior and paves the way for retention strategy for healthcare management.

Research limitations/implications
This study yields a series of limitations in its results and conclusions. These limitations and future research are discussed in Section 7 of the study.

Originality/value
This study contributes to the literature by examining the effects of healthcare service quality on patient satisfaction and perceived value, determining the effect of healthcare service quality on patients’ behavioral intention, and testing the proposed framework in Ghana, a fast growing and economically liberalized emerging country in Sub-Saharan Africa.
Online corporate communications: website usability and content
Authors: García García María , Carrillo-Durán M. Victoria , Tato Jimenez Juan Luis 
Published: March 2017

Purpose
The purpose of this paper is to establish a categorization of corporate websites as tools of online communication, in accordance with how they apply usability to the content they present, and to determine the indicators of the content and usability variables which mark the differences between each group of websites.

Design/methodology/approach
The present study analyses how 754 firms manage the usability of the content they provide through the channels of their corporate websites. To this end, a cluster analysis was applied to distinguish the types of firms according to the usability and content of their websites, followed by a discriminant analysis to determine which variables differentiate the groups.

Findings
The work has presented a list of the indicators that the literature has considered to be determinant aspects of firms’ use of their websites for corporate strategic communications. These indicators can be applied in forming an instrument to measure the quality of company websites in this area.

Originality/value
The present paper has attempted to clarify the panorama of corporate online communication via websites, understanding the issue as being not just a mere technicality but addressing it from the perspective of the emitter of the communication as a strategic instrument.