bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an Emergency Medicine Wellness Curriculum
Authors: Williamson Kelly , Lank Patrick M. , Lovell Elise O. ,   the Emergency Medicine Education Research Alliance (EMERA)
Published: November 2017

AbstractBurnout, the triad of emotional exhaustion, depersonalization, and low personal accomplishment, begins early in medical education and the prevalence continues to increase over time among U.S. physicians. The Accreditation Council for Graduate Medical Education (ACGME) now requires that programs and sponsoring institutions have the same responsibility to address well‐being as they do other aspects of resident competence. Yet, there are no studies published in the emergency medicine (EM) literature that discuss the development and institution of a formal wellness curriculum. The authors conducted a needs analysis among EM residents with the aim of creating a multifaceted 12‐month wellness curriculum. The needs analysis determined that residents are not comfortable with their knowledge of wellness principles. In response, the authors developed a curriculum by integrating components of published non‐EM wellness curricula and online academic wellness programs with commonly accepted domains of wellness. The curriculum was subsequently introduced at five EM residencies. This curriculum represents an example of successful multi‐institution collaboration to meet an ACGME Common Program Requirement.
Dual Functionalization of White Phosphorus: Formation, Characterization, and Reactivity of Rare‐Earth‐Metal Cyclo‐P3 Complexes
Authors: Du Shanshan , Yin Jianhao , Chi Yue , Xu Ling , Zhang Wen‐Xiong 
Published: November 2017

AbstractThe [3+1] fragmentation reaction of rare‐earth metallacyclopentadienes 1 a–c with 0.5 equivalents of P4 affords a series of rare‐earth metal cyclo‐P3 complexes 2 a–c and a phospholyl anion 3. 2 a–c demonstrate an unusual η3 coordination mode with one P−P bond featuring partial π‐bonding character. 2 a–c are the first cyclo‐P3 complexes of rare‐earth metals, and also the first organo‐substituted polyphosphides in the category of Group 3 and f‐block elements. Rare‐earth metallacyclopentadienes play a dual role in the combination of aromatization and Diels–Alder reaction. Compounds 2 a–c can coordinate to one or two [W(CO)5] units, yielding 4 a–c or 5 c, respectively. Furthermore, oxidation of 2 a with p‐benzoquinone produces its corresponding phospholyllithium and regenerated P4.
Selective Functionalization of Aromatic C(sp2)−H Bonds in the Presence of Benzylic C(sp3)−H Bonds by Electron‐Deficient Carbenoids Generated from 4‐Acyl‐1‐Sulfonyl‐1,2,3‐Triazoles
Authors: Miura Tomoya , Zhao Qiang , Murakami Masahiro 
Published: November 2017

AbstractA rhodium(II)‐catalyzed reaction of newly prepared 4‐acyl‐1‐sulfonyl‐1,2,3‐triazoles with benzene, and its derivatives, is investigated. Acceptor/acceptor carbenoids generated from 4‐acyltriazoles undergo selective insertion at aromatic C(sp2)−H bonds in the presence of benzylic C(sp3)−H bonds to produce N‐sulfonylenaminones.
Processability‐enhanced bimodal high‐density polyethylene with comb‐branched high‐density polyethylene
Authors: Tsou Andy H. , Doufas Antonios K. , Atienza Crisita Carmen H. , Passino Hillary L. 
Published: November 2017

ABSTRACTTwo solution reactors in series were utilized to synthesize comb‐branched high‐density polyethylene (HDPE), cbHDPE, where the first reactor prepares vinyl‐terminated HDPE macromers catalyzed by an organometallic catalyst favoring beta hydride transfer and the second reactor copolymerizes HDPE macromers with ethylene using a different organometallic catalyst capable of incorporating macromers. A bimodal HDPE, biHDPE with bimodalities in molecular weight, and hexene content of the desired composition distribution was also prepared in a gas phase reactor using silica supported dual organometallic catalysts. By blending 3% solution‐made cbHDPE into the gas‐phase biHDPE, the resulting trimodal HDPE preserves the excellent stiffness and toughness of the bimodal HDPE while having exceptional melt strength and processability. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45755.
A general framework for constraint approaches to adjusted risk differences
Authors: Tang Yuanyuan , Xia Michelle , Sun Liangrui , Spertus John A. , Jones Philip G. 
Published: November 2017

AbstractThe risk difference is an intelligible measure for comparing disease incidence in two exposure or treatment groups. Despite its convenience in interpretation, it is less prevalent in epidemiological and clinical areas where regression models are required in order to adjust for confounding. One major barrier to its popularity is that standard linear binomial or Poisson regression models can provide estimated probabilities out of the range of (0,1), resulting in possible convergence issues. For estimating adjusted risk differences, we propose a general framework covering various constraint approaches based on binomial and Poisson regression models. The proposed methods span the areas of ordinary least squares, maximum likelihood estimation, and Bayesian inference. Compared to existing approaches, our methods prevent estimates and confidence intervals of predicted probabilities from falling out of the valid range. Through extensive simulation studies, we demonstrate that the proposed methods solve the issue of having estimates or confidence limits of predicted probabilities out of (0,1), while offering performance comparable to its alternative in terms of the bias, variability, and coverage rates in point and interval estimation of the risk difference. An application study is performed using data from the Prospective Registry Evaluating Myocardial Infarction: Event and Recovery (PREMIER) study.
The short‐ and long‐term efficacy analysis of stereotactic surgery combined external ventricular drainage in the treatment of the secondary intraventricular hemorrhage
Authors: Han Wei Yi , Tao Ying Qun , Xu Feng , Zhang You Qian , Li Zhi Yong , Liang Guo Biao 
Published: November 2017

AbstractObjectiveTo evaluate the clinical value of minimally invasive stereotactic puncture therapy (MISPT) combined with external ventricular drainage (EVD) on secondary intraventricular hemorrhage (SIVH).MethodsA retrospective analysis of the patients of intraventricular hemorrhage from May 2013 to January 2015 was conducted in our hospital, according to the enrollment criterion; of which 40 patients were treated by MISPT combined with EVD (ME group) and 45 patients by conventional craniotomy combined with EVD (CE group). Related indicators were compared in the two groups of patients with short‐ and long‐term efficacy.ResultsThe patients in the ME group showed obvious amelioration in the GCS score compared with that of the CE group. There were no statistically significant differences in Graeb score and hematoma volume. Compared with the CE group, the incidence of postoperative complications was significantly decreased in the ME group. The mortalities of the ME and CE groups were 13.3% and 22.6%, respectively. The incidences of rebleeding in the ME and CE groups were 10.0% and 15.6%, respectively. For the four parameters representing long‐term efficacy of 6 months postoperation, the Glasgow Outcome Scale (GOS), Barthel Index (BI), modified Rankin Scale (mRS), and Karnofsky Scale (KPS) scores in the ME group were ameliorated more significantly than those of the CE group.ConclusionsOur data showed that the main advantages of ME in the treatment for SIVH were in minimal trauma, low incidence of complications, and the possibility to improve the long‐term prognosis significantly.
Organizational Culture and Environmental Activity Management
Authors: Baird Kevin , Su Sophia , Tung Amy 
Published: November 2017

AbstractThis study uses the mail survey approach to examine the association between four of the Organizational Culture Profile dimensions of O'Reilly et al. (1991) (teamwork, innovation, outcome orientation and attention to detail) and the adoption of environmental activity management (EAM). The findings indicate that three dimensions of organizational culture (teamwork, innovation and attention to detail) exhibit an association with specific dimensions of EAM. Specifically, teamwork is positively associated with the extent of use of environmental activity analysis, innovation is positively associated with the extent of use of both environmental activity cost analysis and environmental activity‐based costing (EABC) and attention to detail is positively associated with extent of use of EABC. The findings contribute to the contingency literature examining the factors influencing the adoption of environmental cost initiatives by providing managers with an insight into the organizational culture that is conducive to the implementation of EAM. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Hitherto unseen survival in an ALK‐positive‐patient with advanced stage adult ganglioneuroblastoma treated with personalized medicine
Authors: Risum Signe , Knigge Ulrich , Langer Seppo W. 
Published: November 2017

Key Clinical MessageSurvival of stage 4 ganglioneuroblastoma (GNB) patients is poor; no reports exist of patients surviving up to 5 years (1, 2). We report the clinical and therapeutic course of a patient with stage 4 GNB surviving beyond expectations due to a multimodal treatment approach incorporating new technologies in cancer diagnostic and treatment.
3D Heterogeneous Co3O4@Co3S4 Nanoarrays Grown on Ni Foam as a Binder‐Free Electrode for Lithium‐Ion Batteries
Authors: Wang Xia , Liu Changkun , Li Qiang , Li Hongsen , Xu Jie , Chu Xianming , Zhang Lijuan , Zhao Guoxia , Li Hongliang , Guo Peizhi , Li Shandong , Zhao Xiu Song 
Published: November 2017

AbstractCo3O4@Co3S4 nanoarrays on Ni foam (abbreviated as Co3O4@Co3S4 NAs) were prepared by using a facile synthesis method, which involves hydrothermal preparation, low‐temperature thermal decomposition of Co(OH)y(CO3)0.5(2‐y) ⋅ 11H2O, and sulfurization. The material exhibited good electrical conductivity, high specific capacity, and cycling stability with a reversible capacity of 1050 mAh g−1 at 200 mA g−1 after 40 cycles and an initial coulombic efficiency of 82.25 %. At a high current density (1500 mA g−1), the capacity reached up to 808.1 mAh g−1. The excellent lithium‐storage performance of Co3O4@Co3S4 NAs can be ascribed to the synergistic effect between Co3O4 and Co3S4, along with the contribution of the Ni foam. The method described in this paper can be extended to enhance the electrochemical performance of other metal oxides.
An Incomplete Spin Transition Associated with a Z′=1→Z′=24 Crystallographic Symmetry Breaking
Authors: Capel Berdiell Izar , Kulmaczewski Rafal , Cespedes Oscar , Halcrow Malcolm A. 
Published: November 2017

AbstractCrystalline [FeL2][BF4]2⋅Me2CO (L=N‐[2,6‐di{pyrazol‐1‐yl}pyrid‐4‐yl]acetamide) is high‐spin at room temperature, and undergoes an abrupt, hysteretic spin‐crossover at T
=137 K (ΔT
=14 K) that proceeds to about 50 % completeness. This is associated with a crystallographic phase transition, from phase 1 (P21/c, Z=4) to phase 2 (P21, Z=48). The cations associate into chains in the crystal through weak intermolecular π⋅⋅⋅π interactions. Phase 2 contains a mixture of high‐spin and low‐spin molecules, which are grouped into triads along these chains. The perchlorate salt [FeL2][ClO4]2⋅Me2CO also adopts phase 1 at room temperature but undergoes a different phase transition near 135 K to phase 3 (P21/c, Z=8) without a change in spin state.
Mass Transport in a Liquid‐Liquid Plug Flow in a Micro‐Capillary Reactor
Authors: Heckmann Christian , Kurt Safa Kutup , Ehrhard Peter , Kockmann Norbert 
Published: November 2017

AbstractMithilfe der Mikroverfahrenstechnik kann die verfahrensspezifische Prozessleistung gegenüber konventionellen Apparaten gesteigert werden. Ein Modell zur Simulation des Stofftransports in einer Flüssig/Flüssig‐Pfropfenströmung in einem Mikrokapillarreaktor wird vorgestellt. Ausgehend von der Interface‐Tracking‐Methode erfolgt die Modellierung auf separaten formangepassten gekoppelten Rechengebieten auf Grundlage einer importierten Grenzflächentopologie. Experimentelle Untersuchungen erfolgen mit einem Standardextraktionssystem. Während der Pfropfenerzeugung findet etwa ein Drittel der Extraktion statt.
Competitive reactive adsorption desulphurization of dibenzothiophene and hydrogenation of naphthalene over Ni/ZnO
Authors: Huang Lichun , Ge Hui , Yan Lai , Wang Guofu , Qin Zhangfeng , Wang Jianguo 
Published: November 2017

AbstractNi‐based catalysts are good alternatives to noble metal ones for hydrogenation. However, few effective sulphur‐resistant supported Ni catalysts are available commercially so far. This paper presents a Ni/ZnO catalyst prepared by coprecipitation. The optimal calcination temperature is found to be 350 °C. A set of experiments were conducted with addition of naphthalene and dibenzothiophene (DBT) as a model diesel. The reactive adsorption desulphurization activity increases with increasing reaction pressure. The Ni/ZnO catalyst exhibits high activity for naphthalene hydrogenation. The presence of naphthalene caused inhibition of the hydrogenation route and the conversion of DBT decreased slightly. DBT inhibited the hydrogenation of naphthalene and the conversion of naphthalene is 98 % and remained unchanged before 20 h time on stream at 0.4 MPa.
Trends and variations in postmastectomy radiation therapy for breast cancer in patients with 1 to 3 positive lymph nodes: A National Cancer Data Base analysis
Authors: Ohri Nisha , Sittig Mark P. , Tsai Chiaojung Jillian , Hwang Eun‐Sil Shelley , Mittendorf Elizabeth Ann , Shi Weiji , Zhang Zhigang , Ho Alice Y. 
Published: November 2017

BACKGROUNDHigh‐level evidence is lacking to guide treatment decisions about postmastectomy radiation therapy (PMRT) in patients who have breast cancer with 1 to 3 positive lymph nodes who receive contemporary systemic therapies, leading to potential variations in PMRT delivery. The objective of this study was to examine nationwide trends in PMRT use in this group.METHODSThe National Cancer Data Base (NCDB) was used to identify 93,372 women who had T1‐T2N1 breast cancer diagnosed between 2003 and 2012. Patients who received neoadjuvant chemotherapy or radiation therapy (RT) and those who had bilateral breast cancers were excluded. Time trends were evaluated using the Cochrane‐Armitage test and correlated the receipt of PMRT with various patient demographic, facility, clinicopathologic, and treatment variables using multivariable logistic regression. A second analysis was performed for patients who were diagnosed during 2010 and included radiation oncologist density as an additional covariate. P values < .0001 were considered statistically significant.RESULTSOverall, 22.5% of the study population received PMRT, representing an increase from 19.1% in 2003 to 30.3% in 2012. Factors associated with greater PMRT use included younger age, lower Charlson‐Deyo comorbidity scores, shorter distance to the treating facility, treatment at a comprehensive cancer program, facility location in the New England Census division, and higher density of radiation oncologists. Increased PMRT use was associated with later year of diagnosis, receipt of chemotherapy, receipt of hormone therapy, higher grade disease, larger tumor size, greater numbers of positive lymph nodes, positive margins, and absence of immediate breast reconstruction (all P < .0001).CONCLUSIONSThe receipt of PMRT by patients with breast cancer who have 1 to 3 positive lymph nodes has increased over time, with wide variability in practice patterns in the United States. Cancer 2018;124:482‐90. © 2017 American Cancer Society.
Prevalence of anthracycline‐related cardiac dysfunction in long‐term survivors of adult‐onset lymphoma
Authors: Armenian Saro H. , Mertens Luc , Slorach Cameron , Venkataraman Kalyanasundaram , Mascarenhas Kristen , Nathwani Nitya , Wong F. Lennie , Forman Stephen J. , Bhatia Smita 
Published: November 2017

BACKGROUNDAnthracycline‐related heart failure is a leading cause of morbidity in survivors of adult‐onset lymphoma. There is a paucity of information on screening for late‐occurring preclinical disease, which, in turn, has limited guidelines for early detection and intervention. The objectives of this study were to examine the prevalence and risk of cardiac dysfunction, as measured by echocardiography (abnormal left ventricular systolic/diastolic function or strain), in lymphoma survivors who received treatment with anthracyclines and to evaluate the diagnostic yield of blood biomarkers in the asymptomatic setting.METHODSLymphoma survivors who underwent hematopoietic cell transplantation (HCT) (n = 78) or received conventional therapy (non‐HCT; n = 77) were compared with each other and with a group of matched controls (n = 51); the study was limited to lymphoma survivors who were >5 years from diagnosis.RESULTSAt a median follow‐up of 9.4 years after diagnosis, 1 in 5 (20.6 %) lymphoma survivors had cardiac dysfunction; the odds of having cardiac dysfunction were 6.6‐fold greater (odds ratio [OR], 6.6; P = .01) among lymphoma survivors compared with matched controls. There was a dose‐dependent risk of cardiac dysfunction according to the cumulative anthracycline dose (controls [referent group], 1‐249 mg/m2 [OR, 4.7; P = .05], and ≥250 mg/m2 [OR, 7.6; P < .01]), but there was no difference in the prevalence of cardiac dysfunction between conventionally treated and HCT survivors. The diagnostic accuracy of cardiac blood biomarkers in the asymptomatic setting was quite poor.CONCLUSIONSIn these long‐term survivors, there was a high rate of cardiac dysfunction that was independent of HCT status. The growing number of lymphoma survivors makes it imperative to identify reliable and cost‐effective strategies to decrease the burden of heart failure in this population. Cancer 2018;124:850‐7. © 2017 American Cancer Society.
Approach for gait analysis in persons with limb loss including residuum and prosthesis socket dynamics
Authors: LaPrè A.K. , Price M.A. , Wedge R.D. , Umberger B.R. , Sup Frank C. 
Published: November 2017

AbstractMusculoskeletal modeling and marker‐based motion capture techniques are commonly used to quantify the motions of body segments, and the forces acting on them during human gait. However, when these techniques are applied to analyze the gait of people with lower limb loss, the clinically relevant interaction between the residual limb and prosthesis socket is typically overlooked. It is known that there is considerable motion and loading at the residuum‐socket interface, yet traditional gait analysis techniques do not account for these factors due to the inability to place tracking markers on the residual limb inside of the socket. In the present work, we used a global optimization technique and anatomical constraints to estimate the motion and loading at the residuum‐socket interface as part of standard gait analysis procedures. We systematically evaluated a range of parameters related to the residuum‐socket interface, such as the number of degrees of freedom, and determined the configuration that yields the best compromise between faithfully tracking experimental marker positions while yielding anatomically realistic residuum‐socket kinematics and loads that agree with data from the literature. Application of the present model to gait analysis for people with lower limb loss will deepen our understanding of the biomechanics of walking with a prosthesis, which should facilitate the development of enhanced rehabilitation protocols and improved assistive devices.
In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF‐00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor
Authors: Ripp Sharon L. , Mukherjee Arnab , Eng Heather , Stock Thomas , Fleishaker Dona , Checchio Tina , Tammara Brinda 
Published: November 2017

AbstractThe dissociated agonists of the glucocorticoid receptor are a novel class of agents in clinical development for rheumatoid arthritis. PF‐04171327 (fosdagrocorat) is a phosphate ester prodrug of PF‐00251802 (dagrocorat), a selective high‐affinity partial agonist of the glucocorticoid receptor, which is further metabolized to PF‐04015475. This study evaluated the cytochrome P450 (CYP)–mediated drug–drug interaction (DDI) potential of PF‐00251802 and PF‐04015475 in vitro and used model‐based prediction approaches to estimate clinical impact. PF‐00251802 is a reversible inhibitor of several CYPs, but modeling has suggested no clinically relevant interaction. PF‐00251802 and PF‐04015475 are time‐dependent inhibitors and inducers of CYP3A in vitro; PF‐00251802 is also a time‐dependent inhibitor of CYP2D6. Model‐based prediction suggested the potential for weak inhibition of CYP3A in vivo. A clinical DDI study was conducted with midazolam, a sensitive CYP3A substrate. A phase 1 open‐label, multiple‐dose study evaluated the effect of PF‐04171327 on midazolam pharmacokinetics and safety in 12 healthy volunteers. Administration of midazolam alone or concomitantly with PF‐04171327 resulted in equivalent pharmacokinetic profiles (AUCinf, 21.17 vs 20.28 ng·h/mL, respectively), indicating that PF‐04171327 had no net effect on CYP3A activity in vivo. These findings support the further development of PF‐00251802 and PF‐04171327 as potential treatments for patients with rheumatoid arthritis (NCT00987038).
Growth and Properties of CH3NH3PbI3 Single Crystal
Authors: Su Jing , Lu Di , Zhang Lei , Wang Di , Bai Yu , Wang Wangfu 
Published: November 2017

AbstractOrganic‐inorganic hybrid perovskites CH3NH3PbI3 single crystals were grown by inversion crystallization with GBL solvent. The structural, thermal properties and morphology of CH3NH3PbI3 crystal were characterized using PXRD, FT‐IR, TG/DTA and TEM methods. The results shows the CH3NH3PbI3 single crystals were of tetragonal phase with lattice constants a = b = 8.8526 Å and c = 12.6523 Å. The peaks of FT‐IR spectrum were assigned. Thermal decomposition mechanism of CH3NH3PbI3 in the temperature range of 25–800 °C were analyzed. HRTEM shows that the crystal grown is of good quality and dendritic crystallization was observed using GBL as solvent.