bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety, Performance, and Satisfaction Outcomes in the Operating Room: A Literature Review
Authors: Joseph Anjali , Bayramzadeh Sara , Zamani Zahra , Rostenberg Bill 
Published: April 2017

Objective: This review of empirical literature focuses on the design of operating rooms (ORs) by investigating the physical environmental features of ORs associated with patient and staff outcomes. Background: Many ORs built more than 30 years ago remain operational today. However, most are inadequately designed to handle the equipment, processes, and people that a contemporary OR needs to accommodate. However, the evidence base for designing ORs has been sorely lacking, and little guidance exists on how OR design can improve safety and performance outcomes. Method: A literature search was conducted using PubMed and the university’s linked databases. The inclusion criteria included peer-reviewed journal articles that reported some aspect of the physical environment of ORs along with outcomes. The study included empirical studies as well as nonempirical best practice papers. Results: This literature review uncovered 211 articles. The main themes that emerged include OR design-related factors, ventilation, temperature and humidity, acoustical environment, lighting, and materials. Some environmental threats to patient safety in the OR include frequent door openings, clutter, poor air quality, surface contamination, and noise. Further, staff performance and satisfaction were impacted by factors such as the OR layout and equipment and furniture ergonomics. Conclusion: This literature review provides an overview of the research organized into design-focused topic areas to support decision-making by architects and designers. This article highlights gaps in the research and identifies areas where best practice and design assumptions need to be evaluated using rigorous design research.
Diagnosis, management and mortality in acute aortic syndrome: results of the Spanish Registry of Acute Aortic Syndrome (RESA-II)
Authors: Evangelista Arturo , Rabasa José Manuel , Mosquera Victor X , Barros Antonio , Fernández-Tarrio Ruben , Calvo-Iglesias Francisco , Ferrera Carlos , Rozado Jose , López-Ayerbe Jordi , Garrote Carmen , San román Jose-Alberto , Nistal Francisco , Sanchez Violeta , García Robles Jose-Antonio , Valera Francisco , Ballester Carlos , Gil-Albarova Oscar , Domínguez Francisco , Vivancos Ricardo , Mateo-Martinez Alicia , Gallego Pastora , González-Molina Mercedes , Fernández-Golfin Covadonga , Josa Miguel , Hurlé Aquilino , Rodríguez-Sanchez Ibon , Rodríguez-Palomares Jose 
Published: April 2017

Background: Recent advances in the diagnosis and treatment of acute aortic syndrome should improve the outcome of this disease. The Spanish Registry of Acute Aortic Syndrome aimed to assess current results in acute aortic syndrome management in a wide cohort of hospitals in the same geographical area. Methods: From January 2012 to January 2014, 26 tertiary hospitals included 629 consecutive patients with acute aortic syndrome: 73% men, mean age 64.7±14 years (range 22–92), 443 type A (70.4%) and 186 type B (29.6%). Results: Time elapsed between symptom onset and diagnosis was <12 hours in 70.7% of cases and <24 hours in 84.0% (median 5 hours; 25th–75th percentiles, 2.7–15.5 hours). Computed tomography was the first diagnostic technique in 78% of patients and transthoracic echocardiography in 15%. Surgical treatment was indicated in 78.3% of type A acute aortic syndrome. The interval between diagnosis and surgery was 4.8 hours (quartile 1–3, 2.5–11.4 hours). Among the patients with type B acute aortic syndrome, treatment was medical in 116 cases (62.4%), endovascular in 61 (32.8%) and surgical in nine (4.8%). Type A mortality during hospitalisation was 25.1% in patients treated surgically and 68% in those treated medically. Mortality in type B was 13.8% in those with medical treatment, 18.0% with endovascular therapy and 33.0% with surgical treatment. Conclusion: Improvements in the diagnosis and treatment of acute aortic syndrome have not resulted in a significant reduction in hospital mortality. The results of this study reflect more overall and less selected information on acute aortic syndrome management and the need for sustained advances in the therapeutic strategy of acute aortic syndrome.
Setting New Directions for Research in Childhood Nephrotic Syndrome: Results From a National Workshop
Authors: Samuel Susan M. , Takano Tomoko , Scott Shannon , Benoit Genevieve , Bitzan Martin , Mammen Cherry , Ryan Laurel , Morgan Catherine ,   the Canadian Childhood Nephrotic Syndrome Project Team, Arora Steven , Beanlands Heather , Benoit Geneviève , Bifsha Panojot , Bitzan Martin , Dart Allison , Eddy Allison , Erickson Robin , Feber Janusz , Filler Guido , Geier Pavel , Grisaru Silviu , Haddad Elie , Mammen Cherry , Midgley Julian , Morgan Catherine , Muruve Daniel , Nettel-Aguirre Alberto , Parekh Rulan , Pinsk Maury , Ryan Laurel , Samuel Susan M. , Scott Shannon , Takano Tomoko , Tee James , Wade Andrew , Zappitelli Michael , Schreuder Michiel 
Published: April 2017

Background: We report on the proceedings of a national workshop held in Canada with the aims to identify priorities for research in childhood nephrotic syndrome and to develop a national strategy to address these priorities. Methods: A diverse group of participants attended the meeting, including patients, family members, researchers, and health care providers. We used small group discussions to explore priorities as perceived by patients and families and by health care providers and researchers. Results: Research evaluating glucocorticoid minimization or glucocorticoid-sparing regimens was a consistent theme in the patient and family discussion group. Families also indicated the need for precise prognostic information at diagnosis, more information to help them choose the best available therapy, and more resources for disease management. Health care providers emphasized the importance of better disease characterization including genotyping and phenotyping patients, better understanding the pathogenesis, and the need of providing targeted therapy and precise prognostic information. Conclusions: These priorities will inform the development and future directions of the Canadian Childhood Nephrotic Syndrome (CHILDNEPH) project, a national research initiative to improve care and outcomes of patients with childhood onset nephrotic syndrome.
Adjuvant Systemic Therapy and Adjuvant Radiation Therapy for Stage I to IIIA Completely Resected Non–Small-Cell Lung Cancers: American Society of Clinical Oncology/Cancer Care Ontario Clinical Practice Guideline Update
Authors: Kris Mark G. , Gaspar Laurie E. , Chaft Jamie E. , Kennedy Erin B. , Azzoli Christopher G. , Ellis Peter M. , Lin Steven H. , Pass Harvey I. , Seth Rahul , Shepherd Frances A. , Spigel David R. , Strawn John R. , Ung Yee C. , Weyant Michael 
Published: April 2017

Purpose The panel updated the American Society of Clinical Oncology (ASCO) adjuvant therapy guideline for resected non–small-cell lung cancers. Methods ASCO convened an update panel and conducted a systematic review of the literature, investigating adjuvant therapy in resected non–small-cell lung cancers. Results The updated evidence base covered questions related to adjuvant systemic therapy and included a systematic review conducted by Cancer Care Ontario current to January 2016. A recent American Society for Radiation Oncology guideline and systematic review, previously endorsed by ASCO, was used as the basis for recommendations for adjuvant radiation therapy. An update of these systematic reviews and a search for studies related to radiation therapy found no additional randomized controlled trials. Recommendations Adjuvant cisplatin-based chemotherapy is recommended for routine use in patients with stage IIA, IIB, or IIIA disease who have undergone complete surgical resections. For individuals with stage IB, adjuvant cisplatin-based chemotherapy is not recommended for routine use. However, a postoperative multimodality evaluation, including a consultation with a medical oncologist, is recommended to assess benefits and risks of adjuvant chemotherapy for each patient. The guideline provides information on factors other than stage to consider when making a recommendation for adjuvant chemotherapy, including tumor size, histopathologic features, and genetic alterations. Adjuvant chemotherapy is not recommended for patients with stage IA disease. Adjuvant radiation therapy is not recommended for patients with resected stage I or II disease. In patients with stage IIIA N2 disease, adjuvant radiation therapy is not recommended for routine use. However, a postoperative multimodality evaluation, including a consultation with a radiation oncologist, is recommended to assess benefits and risks of adjuvant radiation therapy for each patient with N2 disease. Additional information is available at www.asco.org/lung-cancer-guidelines and www.asco.org/guidelineswiki .
Significance of Optimization of Phospholipid Poly(Ethylene Glycol) Quantity for Coating Carbon Nanohorns to Achieve Low Cytotoxicity
Authors: Nakamura Maki , Tahara Yoshio , Fukata Shinsuke , Zhang Minfang , Yang Mei , Iijima Sumio , Yudasaka Masako 
Published: April 2017

Abstract
In biological studies, phospholipid poly(ethylene glycol) (PLPEG) is used to disperse nanocarbons, which effectively reduces the macrophage uptake of nanocarbons. Single-walled carbon nanohorn (CNH), a type of nanocarbon, was dispersed with PLPEG in this study, and the effect of PLPEG quantity on the cytotoxicity of PLPEG-CNH in RAW264.7 mouse macrophages was revealed. The results were compared with the macrophage uptake quantity of PLPEG-CNH or agglomeration size of PLPEG-CNH. It is concluded that the optimum PLPEG:CNH weight ratio was 0.5:1 and 1:1. At the higher or lower ratios, the PLPEG-CNH toxicity and the macrophage uptake quantity increased and large agglomerates appeared. These tendencies at the lower PLPEG:CNH ratio were caused by the CNHs surfaces not being sufficiently well covered by PLPEG. The tendency at the higher PLPEG:CNH ratio was curious, for which we deduced that PLPEG adsorbed on CNHs was detached to form micelles, leading to the reappearance of the CNHs not well covered with PLPEG.
Development of Neighboring Electrophilic Activation of Active Center in Catalytic Reactions via Organometallic Intermediates
Authors: Endo Kohei 
Published: April 2017

Abstract
Strategies for electrophilic activation by neighboring atoms should contribute to the development of novel catalytic performance in organic reactions. Neighboring electron-withdrawing Lewis acidic atoms can change the character of molecular catalysts, which might be more electrophilic toward inactive electron-rich molecules. In this context, the development of carbene intermediates, diborylmethane derivatives, and multinuclear catalysts has realized efficient transformations. The use of cyclopropenes can generate electrophilic carbenoid intermediates in the presence of a Ag-catalyst, the reaction of which with an organozinc reagent gives allylzinc intermediates. The subsequent allylation reaction of other electrophiles takes place in situ as a 3-components coupling reaction. The novel reactivity of diborylmethane derivatives shows the generation of borate intermediates under ambient conditions, which can take part in the Suzuki–Miyaura cross-coupling reaction. The mono-coupling reaction occurs exclusively without di-coupling reaction to give alkylboronates. The stereoselective synthesis of tetrasubstituted alkenylboronates was successful via the deprotonation of diborylalkanes, subsequent nucleophilic attack to ketones, and syn-elimination. The development of multinuclear catalysts using phosphorous ligands bearing protic moieties has realized efficient stereoselective 1,4-addition reaction of organozinc and organoaluminum reagents, where the creation of chiral quaternary stereogenic centers using acyclic enones is notable.
Development of a clinical algorithm for treating urethral strictures based on a large retrospective single-center cohort
Authors: Tolkach Yuri , Herrmann Thomas , Merseburger Axel , Burchardt Martin , Wolters Mathias , Huusmann Stefan , Kramer Mario , Kuczyk Markus , Imkamp Florian 
Published: April 2017

Aim: To analyze clinical data from male patients treated with urethrotomy and to develop a clinical decision algorithm. Materials and methods: Two large cohorts of male patients with urethral strictures were included in this retrospective study, historical (1985-1995, n=491) and modern cohorts (1996-2006, n=470). All patients were treated with repeated internal urethrotomies (up to 9 sessions). Clinical outcomes were analyzed and systemized as a clinical decision algorithm. Results: The overall recurrence rates after the first urethrotomy were 32.4% and 23% in the historical and modern cohorts, respectively. In many patients, the second procedure was also effective with the third procedure also feasible in selected patients. The strictures with a length ≤ 2 cm should be treated according to the initial length. In patients with strictures ≤ 1 cm, the second session could be recommended in all patients, but not with penile strictures, strictures related to transurethral operations or for patients who were 31-50 years of age. The third session could be effective in selected cases of idiopathic bulbar strictures. For strictures with a length of 1-2 cm, a second operation is possible for the solitary low-grade bulbar strictures, given that the age is > 50 years and the etiology is not post-transurethral resection of the prostate. For penile strictures that are 1-2 cm, urethrotomy could be attempted in solitary but not in high-grade strictures. Conclusions: We present data on the treatment of urethral strictures with urethrotomy from a single center. Based on the analysis, a clinical decision algorithm was suggested, which could be a reliable basis for everyday clinical practice.
Książka naukowa – między środowiskiem akademickim a branżą wydawniczą
Authors: Breczko Sylwia 
Published: April 2017

Celem artykułu jest zwrócenie uwagi na książkę naukową jako przedmiot badawczy, istniejący na przecięciu socjologicznego nurtu badań nad szkolnictwem wyższym i badań nad rynkiem książki. Książka naukowa od lat dominuje na polskim rynku książki w zakresie liczby publikowanych pierwszych wydań, jednak jej znaczenie dla rynku wydawniczego uznawane jest za znikome. Równocześnie monografia naukowa, przez lata uważana – przynajmniej w obszarze nauk humanistycznych i społecznych – za „złoty standard” pracy naukowej, będący wyznacznikiem prestiżu i podstawą awansu akademickiego, zmienia swoją funkcję wraz z reformami szkolnictwa wyższego w Polsce, w coraz większym stopniu nastawionymi na docenianie artykułów w najbardziej uznanych czasopismach (najlepiej z impact factor) i publikacji w formule open access, a także w obliczu dokonujących się innowacji technologicznych dotyczących produkcji, opracowania i dystrybucji tekstu. Analiza tych przemian poprzez poznanie głównych interesariuszy (naukowców i wydawców, ale również bibliotekarzy, księgarzy, czytelników, nie zapominając o politycznych decydentach i gremiach eksperckich odpowiedzialnych za politykę w zakresie nauki i szkolnictwa wyższego) i ich zaplecza instytucjonalnego może nie tylko mieć znaczenie teoretyczne, ale także przyczynić się do dyskusji nad rolą wydawców naukowych i znaczeniem samej monografii naukowej w kontekście przyszłych reform szkolnictwa wyższego.
Nadane stopnie i tytuły naukowe – czy coś się zmieniło?
Authors: Rodzik Piotr 
Published: April 2017

Artykuł poświęcony jest trendom w obszarze nadawanych w kraju stopni naukowych doktora i doktora habilitowanego, stopni w zakresie sztuki oraz tytułu naukowego profesora i tytułu profesora w zakresie sztuki. Podczas prezentacji wyników uwzględniono podział osób uzyskujących stopnie i tytuły według płci. Pokazano, jak zmienia się liczba osób, którym nadano stopnie i tytuły w kolejnych latach. Omówiono strukturę nadanych stopni/tytułów w poszczególnych obszarach nauki i sztuki. Określono również, jak zmienia się liczba nadanych stopni i tytułów w poszczególnych latach w zależności od wieku osób uzyskujących stopień lub tytuł. Analizy oparto na danych jednostkowych znajdujących się w Bazie Wiedzy o Nauce Polskiej i obejmujących ostatnie 16 lat (2000-2015).
Change of School Playground Environment on Bullying: A Randomized Controlled Trial
Authors: Farmer Victoria L. , Williams Sheila M. , Mann Jim I. , Schofield Grant , McPhee Julia C. , Taylor Rachael W. 
Published: April 2017

OBJECTIVE:To investigate whether increasing risk and challenge in primary school playgrounds influences interactions between children.METHODS:In a 2-year cluster-randomized controlled trial, 8 control schools were asked to not change their play environment, whereas 8 intervention schools increased opportunities for risk and challenge (eg, rough-and-tumble play), reduced rules, and added loose parts (eg, tires). Children (n = 840), parents (n = 635), and teachers (n = 90) completed bullying questionnaires at baseline, 1 (postintervention), and 2 (follow-up) years.RESULTS:Intervention children reported higher odds of being happy at school (at 2 years, odds ratio [OR]: 1.64; 95% confidence interval [CI]: 1.20–2.25) and playing with more children (at 1 year, OR: 1.66; 95% CI: 1.29–2.15) than control children. Although intervention children indicated they were pushed/shoved more (OR: 1.33; 95% CI: 1.03–1.71), they were less likely to tell a teacher (OR: 0.69; 95% CI: 0.52–0.92) at 2 years. No significant group differences were observed in parents reporting whether children had “ever” been bullied at school (1 year: P = .23; 2 years: P = .07). Intervention school teachers noticed more bullying in break time at 1 year (difference in scores: 0.20; 95% CI: 0.06–0.34; P = .009), with no corresponding increase in children reporting bullying to teachers (both time points, P ≥ .26).CONCLUSIONS:Few negative outcomes were reported by children or parents, except for greater pushing/shoving in intervention schools. Whether this indicates increased resilience as indicated by lower reporting of bullying to teachers may be an unanticipated benefit.
Nonemergency Acute Care: When It’s Not the Medical Home
Authors: Conners Gregory P. , Kressly Susan J. , Perrin James M. , Richerson Julia E. , Sankrithi Usha M. ,   COMMITTEE ON PRACTICE AND AMBULATORY MEDICINE,   COMMITTEE ON PEDIATRIC EMERGENCY MEDICINE,   SECTION ON TELEHEALTH CARE,   SECTION ON EMERGENCY MEDICINE,   SUBCOMMITTEE ON URGENT CARE,   TASK FORCE ON PEDIATRIC PRACTICE CHANGE, Simon Geoffrey R. , Boudreau Alexy D. Arauz , Baker Cynthia , Barden Graham A. , Hackell Jesse , Hardin Amy , Meade Kelley , Moore Scot , Shook Joan E. , Callahan James M. , Chun Thomas H. , Conway Edward E. , Dudley Nanette C. , Gross Toni K. , Lane Natalie E. , Macias Charles G. , Timm Nathan L. , Alexander Joshua J. , Bell Denise M. , Bunik Maya , Burke Bryan L. , Herendeen Neil E. , Kahn Joseph A. , Macias Charles G. , Mahajan Prashant V. , Gorelick Marc H. , Bajaj Lalit , Gonzalez del Rey Javier A. , Herr Sandra , Mull Colette C. , Schnadower David , Sirbaugh Paul E. , Lumba-Brown Angela , Dahl-Grove Deanna L. , Gross Toni K. , McAneney Constance M. , Remick Katherine E. , Sirbaugh Paul E. , Kharbanda Anupam , Nigrovic Lise , Mullan Paul C. , Wolff Margaret S. , Schor Jeffrey A. , Edwards Anne R. , Alexander Joshua J. , Flanagan Patricia J. , Hudak Mark L. , Katkin Julie P. , Kraft Colleen A. , Quinonez Ricardo A. , Shenkin Budd N. , Smith Tyler K. , Tieder Joel S. 
Published: April 2017

This Policy Statement was reaffirmed April 2024.
The American Academy of Pediatrics (AAP) affirms that the optimal location for children to receive care for acute, nonemergency health concerns is the medical home. The medical home is characterized by the AAP as a care model that “must be accessible, family centered, continuous, comprehensive, coordinated, compassionate, and culturally effective.” However, some children and families use acute care services outside the medical home because there is a perceived or real benefit related to accessibility, convenience, or cost of care. Examples of such acute care entities include urgent care facilities, retail-based clinics, and commercial telemedicine services. Children deserve high-quality, appropriate, and safe acute care services wherever they access the health care system, with timely and complete communication with the medical home, to ensure coordinated and continuous care. Treatment of children under established, new, and evolving practice arrangements in acute care entities should adhere to the core principles of continuity of care and communication, best practices within a defined scope of services, pediatric-trained staff, safe transitions of care, and continuous improvement. In support of the medical home, the AAP urges stakeholders, including payers, to avoid any incentives (eg, reduced copays) that encourage visits to external entities for acute issues as a preference over the medical home.
Csökkent munkaképességű krónikus mozgásszervi betegek reintegrációjának elősegítése
Authors: Sallai Julianna Rozália , Hunka Aniella , Héjj Gábor , Bálint Géza , Poór Gyula 
Published: April 2017

Abstract: Introduction: An important task of our institute is to support social reintegration: including occupational rehabilitation of patients suffering from chronic musculoskeletal diseases with decreased working ability. Aim: The aim of the authors was to provide informations of their daily practice, how they perform patient education, giving information for their patients about their disease, the rehabilitation possibilities, how they support the patients with decreased working ability to take part in their own rehabilitation. Method: Patients taking part in in-patient rehabilitation received teaching and education about their disease and rehabilitation options in groups. Patients interested in part-time jobs were individually interviewed by a 30–120 minutes talk about their educational level and training, social conditions and about the available part time jobs. The part time jobs were available with the help of the Motivation Foundation of the National Association of the Societies of Motion Disabled, and the Alfa Rehabilitation Nonprofit Rt. The data of patients receiving in-patient rehabilitation betwen the 1st of January 2009 and 31st of December 2014 were analyzed. Results: Out of the 230 patients seeking our help for part time job, our social service could organise jobs for 180 disabled persons, all town-inhabitants, but was unsuccesful in getting jobs for patients living in villages and separated farms. Conclusion: Part time jobs can be organized for musculoskeletal disabled living in cities and towns. For village-dwellers there are no suitable jobs and working places. It is necessary to organize rehabilitation working possibitities for musculoskeletal disabled patients living in villages. Orv Hetil. 2017; 158(17): 662–667.
A Lewy-testes demencia klinikai és neuropatológiai jellemzői
Authors: Bencze János , Simon Viktória , Bereczki Erika , Majer Réka , Varkoly Gréta , Murnyák Balázs , Kálmán János , Hortobágyi Tibor 
Published: April 2017

Abstract: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. The accurate diagnosis is often possible only by neuropathological examination. The morphologic hallmarks are the presence of α-synuclein-rich Lewy bodies and Lewy neurites, identical to those seen in Parkinson’s disease (PD) and Parkinson’s disease dementia (PDD). Neurotransmitter deficits, synaptic and ubiquitin-proteasome system (UPS) dysfunction play major role in the pathomechanism. Characteristic symptoms are cognitive fluctuation, parkinsonism and visual hallucinations. Due to the often atypical clinical presentation novel imaging techniques and biomarkers could help the early diagnosis. Although curative treatment is not available, therapies can improve quality of life. Clinicopathological studies are important in exploring pathomechanisms, ensuring accurate diagnosis and identifying therapeutic targets. Orv Hetil. 2017; 158(17): 643–652.