bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of pre- and postnatal maternal stress on infant temperament and autonomic nervous system reactivity and regulation in a diverse, low-income population
Authors: Bush Nicole R. , Jones-Mason Karen , Coccia Michael , Caron Zoe , Alkon Abbey , Thomas Melanie , Coleman-Phox Kim , Wadhwa Pathik D. , Laraia Barbara A. , Adler Nancy E. , Epel Elissa S. 
Published: November 2017

AbstractWe examined the prospective associations of objective and subjective measures of stress during pregnancy with infant stress reactivity and regulation, an early-life predictor of psychopathology. In a racially and ethnically diverse low-income sample of 151 mother–infant dyads, maternal reports of stressful life events (SLE) and perceived stress (PS) were collected serially over gestation and the early postpartum period. Infant reactivity and regulation at 6 months of age was assessed via maternal report of temperament (negativity, surgency, and regulation) and infant parasympathetic nervous system physiology (respiratory sinus arrhythmia [RSA]) during the Still Face Paradigm. Regression models predicting infant temperament showed higher maternal prenatal PS predicted lower surgency and self-regulation but not negativity. Regression models predicting infant physiology showed higher numbers of SLE during gestation predicted greater RSA reactivity and weaker recovery. Tests of interactions revealed SLE predicted RSA reactivity only at moderate to high levels of PS. Thus, findings suggest objective and subjective measures of maternal prenatal stress uniquely predict infant behavior and physiology, adjusting for key pre- and postnatal covariates, and advance the limited evidence for such prenatal programming within high-risk populations. Assessing multiple levels of maternal stress and offspring stress reactivity and regulation provides a richer picture of intergenerational transmission of adversity.
Reward sensitivity, impulse control, and social cognition as mediators of the link between childhood family adversity and externalizing behavior in eight countries
Authors: Lansford Jennifer E. , Godwin Jennifer , Bornstein Marc H. , Chang Lei , Deater-Deckard Kirby , Di Giunta Laura , Dodge Kenneth A. , Malone Patrick S. , Oburu Paul , Pastorelli Concetta , Skinner Ann T. , Sorbring Emma , Steinberg Laurence , Tapanya Sombat , Alampay Liane Peña , Uribe Tirado Liliana Maria , Al-Hassan Suha M. , Bacchini Dario 
Published: November 2017

AbstractUsing data from 1,177 families in eight countries (Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the United States), we tested a conceptual model of direct effects of childhood family adversity on subsequent externalizing behaviors as well as indirect effects through psychological mediators. When children were 9 years old, mothers and fathers reported on financial difficulties and their use of corporal punishment, and children reported perceptions of their parents’ rejection. When children were 10 years old, they completed a computerized battery of tasks assessing reward sensitivity and impulse control and responded to questions about hypothetical social provocations to assess their hostile attributions and proclivity for aggressive responding. When children were 12 years old, they reported on their externalizing behavior. Multigroup structural equation models revealed that across all eight countries, childhood family adversity had direct effects on externalizing behaviors 3 years later, and childhood family adversity had indirect effects on externalizing behavior through psychological mediators. The findings suggest ways in which family-level adversity poses risk for children's subsequent development of problems at psychological and behavioral levels, situated within diverse cultural contexts.
Dimensions of childhood adversity have distinct associations with neural systems underlying executive functioning
Authors: Sheridan Margaret A. , Peverill Matthew , Finn Amy S. , McLaughlin Katie A. 
Published: November 2017

AbstractChildhood adversity is associated with increased risk for psychopathology. Neurodevelopmental pathways underlying this risk remain poorly understood. A recent conceptual model posits that childhood adversity can be deconstructed into at least two underlying dimensions, deprivation and threat, that are associated with distinct neurocognitive consequences. This model argues that deprivation (i.e., a lack of cognitive stimulation and learning opportunities) is associated with poor executive function (EF), whereas threat is not. We examine this hypothesis in two studies measuring EF at multiple levels: performance on EF tasks, neural recruitment during EF, and problems with EF in daily life. In Study 1, deprivation (low parental education and child neglect) was associated with greater parent-reported problems with EF in adolescents (N= 169; 13–17 years) after adjustment for levels of threat (community violence and abuse), which were unrelated to EF. In Study 2, low parental education was associated with poor working memory (WM) performance and inefficient neural recruitment in the parietal and prefrontal cortex during high WM load among adolescents (N= 51, 13–20 years) after adjusting for abuse, which was unrelated to WM task performance and neural recruitment during WM. These findings constitute strong preliminary evidence for a novel model of the neurodevelopmental consequences of childhood adversity.
Does striving to succeed come at a physiological or psychosocial cost for adults who experienced child maltreatment?
Authors: Doom Jenalee R. , Hazzard Vivienne M. , Bauer Katherine W. , Clark Cari Jo , Miller Alison L. 
Published: November 2017

AbstractWhile striving to succeed in the face of adversity may provide individuals with outward benefits, it may come at a cost to individuals’ physical health. The current study examines whether striving predicts greater physiological or psychosocial costs among those who experienced child maltreatment, a stressor that disrupts the caregiving environment and threatens relationship security. Using data from the National Longitudinal Study of Adolescent to Adult Health, we tested whether greater striving after childhood maltreatment would come at a cost, increasing underlying cardiovascular disease (CVD) risk and depressive symptoms despite showing outward success via income and college degree attainment. The study included 13,341 Black, Hispanic, and White adolescents who self-reported striving and their experiences of childhood neglect, physical abuse, and sexual abuse. As young adults, participants reported depressive symptoms, income, and college degree attainment and completed a health assessment from which a 30-year Framingham-based CVD risk score was calculated. Higher striving was associated with lower CVD risk and depressive symptoms, and higher income and college degree attainment, regardless of maltreatment history. These findings highlight the potential for striving as a target for interventions and support the need to examine multiple biological and behavioral outcomes to understand the multifaceted nature of resilience.
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
Authors: Liu Juan , Zhang Cen , Zhao Yuhan , Yue Xuetian , Wu Hao , Huang Shan , Chen James , Tomsky Kyle , Xie Haiyang , Khella Christen A. , Gatza Michael L. , Xia Dajing , Gao Jimin , White Eileen , Haffty Bruce G. , Hu Wenwei , Feng Zhaohui 
Published: November 2017

AbstractMutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson’s disease. Accumulating evidence suggests that Parkin is a tumor suppressor, but the underlying mechanism is poorly understood. Here we show that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1α (HIF-1α). Parkin interacts with HIF-1α and promotes HIF-1α degradation through ubiquitination, which in turn inhibits metastasis of breast cancer cells. Parkin downregulation in breast cancer cells promotes metastasis, which can be inhibited by targeting HIF-1α with RNA interference or the small-molecule inhibitor YC-1. We further identify lysine 477 (K477) of HIF-1α as a major ubiquitination site for Parkin. K477R HIF-1α mutation and specific cancer-associated Parkin mutations largely abolish the functions of Parkin to ubiquitinate HIF-1α and inhibit cancer metastasis. Importantly, Parkin expression is inversely correlated with HIF-1α expression and metastasis in breast cancer. Our results reveal an important mechanism for Parkin in tumor suppression and HIF-1α regulation.
Allosteric inhibitor remotely modulates the conformation of the orthestric pockets in mutant IDH2/R140Q
Authors: Chen Jiao , Yang Jie , Sun Xianqiang , Wang Zhongming , Cheng Xiaolan , Lu Wuguang , Cai Xueting , Hu Chunping , Shen Xu , Cao Peng 
Published: November 2017

AbstractNeomorphic mutation R140Q in the metabolic enzyme isocitrate dehydrogenase 2 (IDH2) is found to be a driver mutation in cancers. Recent studies revealed that allosteric inhibitors could selectively inhibit IDH2/R140Q and induce differentiation of TF-1 erythroleukemia and primary human AML cells. However, the allosteric inhibition mechanism is not very clear. Here, we report the results from computational studies that AGI-6780 binds tightly with the divalent cation binding helices at the homodimer interface and prevents the transition of IDH2/R140Q homodimer to a closed conformation that is required for catalysis, resulting in the decrease of the binding free energy of NADPHs. If the allosteric inhibitor is removed, the original open catalytic center of IDH2/R140Q will gradually reorganize to a quasi-closed conformation and the enzymatic activity might recover. Unlike IDH2/R140Q, AGI-6780 locks one monomer of the wild-type IDH2 in an inactive open conformation and the other in a half-closed conformation, which can be used to explain the selectivity of AGI-6780. Our results suggest that conformational changes are the primary contributors to the inhibitory potency of the allosteric inhibitor. Our study will also facilitate the understanding of the inhibitory and selective mechanisms of AG-221 (a promising allosteric inhibitor that has been approved by FDA) for mutant IDH2.
Robust generation of entangled state via ground-state antiblockade of Rydberg atoms
Authors: Zhao Y. J. , Liu B. , Ji Y. Q. , Tang S. Q. , Shao X. Q. 
Published: November 2017

AbstractWe propose a mechanism of ground-state antiblockade of Rydberg atoms, which is then exploited to prepare two-atom entangled state via three different kinds of pulses. First we use the pulses in the form of sin2 and cos2 functions and obtain a maximally entangled state at an accurate interaction time. Then the method of stimulated Raman adiabatic passage (STIRAP) is adopted for the entanglement generation, which is immune to the fluctuations of revelent parameters but requires a long time. Finally we capitalize the advantages of the former two methods and employ shortcuts to adiabatic passage (STAP) to generate the maximal entanglement. The strictly numerical simulation reveals that the current scheme is robust against spontaneous emission of atoms due to the virtual excitation of Rydberg states, and all of the above methods favor a high fidelity with the present experimental technology.
Characteristic of entire corneal topography and tomography for the detection of sub-clinical keratoconus with Zernike polynomials using Pentacam
Authors: Xu Zhe , Li Weibo , Jiang Jun , Zhuang Xiran , Chen Wei , Peng Mei , Wang Jianhua , Lu Fan , Shen Meixiao , Wang Yuanyuan 
Published: November 2017

AbstractThe study aimed to characterize the entire corneal topography and tomography for the detection of sub-clinical keratoconus (KC) with a Zernike application method. Normal subjects (n = 147; 147 eyes), sub-clinical KC patients (n = 77; 77 eyes), and KC patients (n = 139; 139 eyes) were imaged with the Pentacam HR system. The entire corneal data of pachymetry and elevation of both the anterior and posterior surfaces were exported from the Pentacam HR software. Zernike polynomials fitting was used to quantify the 3D distribution of the corneal thickness and surface elevation. The root mean square (RMS) values for each order and the total high-order irregularity were calculated. Multimeric discriminant functions combined with individual indices were built using linear step discriminant analysis. Receiver operating characteristic curves determined the diagnostic accuracy (area under the curve, AUC). The 3rd-order RMS of the posterior surface (AUC: 0.928) obtained the highest discriminating capability in sub-clinical KC eyes. The multimeric function, which consisted of the Zernike fitting indices of corneal posterior elevation, showed the highest discriminant ability (AUC: 0.951). Indices generated from the elevation of posterior surface and thickness measurements over the entire cornea using the Zernike method based on the Pentacam HR system were able to identify very early KC.
Exteroceptive expectations modulate interoceptive processing: repetition-suppression effects for visual and heartbeat evoked potentials
Authors: Marshall Amanda C. , Gentsch Antje , Jelinčić Valentina , Schütz-Bosbach Simone 
Published: November 2017

AbstractInteroception refers to the signaling of internal bodily commands. Here, we explore repetition suppression of intero- and exteroceptive neural markers to test whether the perception and predictability of exteroceptive stimulus material affects their expression. Participants completed a repetition suppression paradigm in which angry or neutral facial expressions repeated or alternated. Participants received either an implicit (experiment 1) or explicit (experiment 2) cue enabling the formation of expectations regarding the upcoming facial expression. We measured the heartbeat-evoked potential (HEP) indexing cardiac processing and visual evoked potentials (VEP) in response to viewing the second (repeated or alternated) face. Repeating angry facial expressions produced repetition suppression of both HEP and VEP amplitude while repeating neutral expressions led to repetition enhancement of HEP amplitude. This effect was magnified when participants were explicitly aware of predictive cues. Furthermore, repetition suppression of HEP amplitude correlated with neural attenuation of VEP activity. Results highlight repetition effects for interoceptive as well as exteroceptive neural markers and support top-down, expectation-based accounts of the phenomenon. Furthermore, results demonstrate that the perception of exteroceptive stimulus information has an effect on the processing of interoceptive signals and suggest a direct neural connection between the processing of external and internal sensory information.
Subdiffusion via dynamical localization induced by thermal equilibrium fluctuations
Authors: Spiechowicz Jakub , Łuczka Jerzy 
Published: November 2017

AbstractWe reveal the mechanism of subdiffusion which emerges in a straightforward, one dimensional classical nonequilibrium dynamics of a Brownian ratchet driven by both a time-periodic force and Gaussian white noise. In a tailored parameter set for which the deterministic counterpart is in a non-chaotic regime, subdiffusion is a long-living transient whose lifetime can be many, many orders of magnitude larger than characteristic time scales of the setup thus being amenable to experimental observations. As a reason for this subdiffusive behaviour in the coordinate space we identify thermal noise induced dynamical localization in the velocity (momentum) space. This novel idea is distinct from existing knowledge and has never been reported for any classical or quantum system. It suggests reconsideration of generally accepted opinion that subdiffusion is due to broad distributions or strong correlations which reflect disorder, trapping, viscoelasticity of the medium or geometrical constraints.
Evaluation of radionuclides and decay simulation in a terrestrial environment for health risk assessment
Authors: Doyi I. N. , Essumang D. K. , Dampare S. B. , Duah D. , Ahwireng A. F. 
Published: November 2017

AbstractThis study is to assess the natural radioactivity level in soil samples in communities bordering the Tano Basin in Ghana. The radioactivity concentration of 238U, 232Th and 40K have been determined using γ-ray spectrometry, moreover, the absorbed dose rates and annual effective dose were calculated. MATLAB R2013 script was written to simulate the decay of the radionuclides 238U, 232Th and 40K using their respective half-lives. This is to determine the future impact of natural radionuclides and estimate future anthropogenic inputs. The level 238U, 232Th, and 40K ranged from (1.60 to 21.3), (2.78 to 32.2) and (111 to 528) with average values of be 8.65 Bqkg−1, 12.5 Bqkg−1 and 214 Bqkg−1 respectively in soil. The activity concentrations were lower than United Nations Scientific Committee on the Effects of Atomic Radiation guidelines for 238U, 232Th and 40K. The absorbed dose rates and annual effective dose were found to be in range of 7.79 to 37.8 nGy h−1 and 9.56E + 00 to 4.64E + 01 µSvy−1 respectively. The overall annual effective dose was lower than the allowable limit of 1mSvy−1 set by International Commission on Radiological Protection. Hex, Hin and excess lifetime cancer risk (ELCR) were calculated and found to be within internationally recommended values.
AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts
Authors: Sanchez-Alvarez Miguel , del Pozo Miguel Angel , Bakal Chris 
Published: November 2017

AbstractInositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases in protein folding competency, and ER expansion/remodeling. However, we still know surprisingly little regarding the principles by which this ER transducer is deactivated upon ER stress clearance. Here we show that Protein Kinase B-mechanistic Target of Rapamycin (PKB/AKT-mTOR) signaling controls the dynamics of IRE1 deactivation by regulating ER-mitochondria physical contacts and the autophosphorylation state of IRE1. AKT-mTOR-mediated attenuation of IRE1 activity is important for ER remodelling dynamics and cell survival in the face of recursive, transient ER stress. Our observations suggest that IRE1 attenuation is an integral component of anabolic programmes regulated by AKT-mTOR. We suggest that AKT-mTOR activity is part of a ‘timing mechanism’ to deactivate IRE1 immediately following engagement of the UPR, in order to limit prolonged IRE1 RNAse activity that could lead to damaging inflammation or apoptosis.
2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2
Authors: Xu Shangfu , Liu Jie , Shi Jingshan , Wang Zhengtao , Ji Lili 
Published: November 2017

AbstractHepatotoxicity induced by medicinal herb Polygonum multiflorum Thunb. attracts wide attention in the world recently. 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) is a main active compound in Polygonum multiflorum Thunb. This study aims to observe TSG-provided the aggravation on acetaminophen (APAP)-induced hepatotoxicity in mice by inducing hepatic expression of cytochrome P450 (CYP450) enzymes. Serum alanine/aspartate aminotransferase (ALT/AST) analysis and liver histological evaluation showed that TSG (200, 400, 800 mg/kg) exacerbated the hepatotoxicity induced by sub-toxic dose of APAP (200 mg/kg) in mice, but TSG alone had no hepatotoxicity. TSG aggravated hepatic reduced glutathione (GSH) depletion and APAP-cysteine adducts (APAP-CYS) formation induced by APAP in mice. TSG increased the expression of CYP2E1, CYP3A4 and CYP1A2 both in mice and in human normal liver L-02 hepatocytes. TSG also enhanced liver catalytic activity of CYP2E1, CYP3A4 and CYP1A2 in mice. TSG induced the nuclear translocation of aryl hydrocarbon receptor (AHR) and pregnane X receptor (PXR), and TSG-provided the aggravation on APAP-induced hepatotoxicity in mice was reversed by PXR or AHR inhibitors. In summary, our results demonstrate that TSG enhances hepatic expression of CYP3A4, CYP2E1 and CYP1A2, and thus exacerbates the hepatotoxicity induced by APAP in mice. PXR and AHR both play some important roles in this process.
Scene grammar shapes the way we interact with objects, strengthens memories, and speeds search
Authors: Draschkow Dejan , Võ Melissa L.-H. 
Published: November 2017

AbstractPredictions of environmental rules (here referred to as “scene grammar”) can come in different forms: seeing a toilet in a living room would violate semantic predictions, while finding a toilet brush next to the toothpaste would violate syntactic predictions. The existence of such predictions has usually been investigated by showing observers images containing such grammatical violations. Conversely, the generative process of creating an environment according to one’s scene grammar and its effects on behavior and memory has received little attention. In a virtual reality paradigm, we either instructed participants to arrange objects according to their scene grammar or against it. Subsequently, participants’ memory for the arrangements was probed using a surprise recall (Exp1), or repeated search (Exp2) task. As a result, participants’ construction behavior showed strategic use of larger, static objects to anchor the location of smaller objects which are generally the goals of everyday actions. Further analysis of this scene construction data revealed possible commonalities between the rules governing word usage in language and object usage in naturalistic environments. Taken together, we revealed some of the building blocks of scene grammar necessary for efficient behavior, which differentially influence how we interact with objects and what we remember about scenes.
Branched Pd@Rh core@shell nanocrystals with exposed Rh {100} facets: an effective electrocatalyst for hydrazine electro-oxidation
Authors: Wang Guojing , Jing Shengchang , Tan Yiwei 
Published: November 2017

AbstractShape control of noble metal (NM) nanocrystals (NCs) is of great importance for improving their electrocatalytic performance. In this report, branched Pd@Rh core@shell NCs that have right square prism-like arms with preferential exposure of Rh {100} facets (denoted as b-Pd@Rh-NCs thereafter) are synthesized and utilized as an electrocatalyst for the hydrazine electrooxidation (HEO) in acidic and alkaline electrolytes. The b-Pd@Rh-NCs are obtained by the heteroepitaxial growth of Rh on the pre-formed branched Pd NCs (denoted as b-Pd-NCs thereafter) core in the presence of poly(vinyl pyrrolidone) (PVP) and bromide ions. A comparative analysis of the voltammetric data for the HEO shows a higher activity on the b-Pd@Rh-NCs exposed with Rh {100} faces than on Rh black, the b-Pd-NCs, and Pd black in acid and alkaline solutions, indicating a structure sensitivity of the reaction. Analysis of the products from the b-Pd@Rh-NCs catalysed HEO reveals a very high hydrazine fuel efficiency, as determined by on-line differential electrochemical mass spectrometry (DEMS).