bluuebunny/crossref_metadata_2025_split huggingface dataset:
State Medicaid Expansion and Citizens’ Quality of Life*
Authors: Flavin Patrick 
Published: July 2017

ObjectivesThe U.S. Supreme Court's 2012 ruling on the Affordable Care Act was a federal exogenous shock that presented all states with the decision to continue their Medicaid program in its current form or expand it to include thousands of newly eligible recipients. This article takes advantage of this exogenous shock to evaluate the impact of Medicaid expansion on citizens’ quality of life.MethodsI evaluate changes from 2010 to 2014 in low‐income citizens’ subjective well‐being (SWB) using Gallup‐Healthways survey data and a difference‐in‐differences estimation strategy.ResultsAverage levels of SWB increased among low‐income citizens in states that expanded Medicaid eligibility compared to states that did not. In a series of placebo tests, I also demonstrate that the expansion had no effect on the SWB of middle‐ or high‐income citizens who are unlikely to directly benefit from more generous Medicaid eligibility requirements.ConclusionsThe empirical findings suggest that the expansion of Medicaid has important implications for the well‐being of low‐income Americans and, more broadly, contribute to the growing literature on how government policy choices can concretely impact the quality of life that citizens experience.
Effect of catheter size and injection rate of contrast agent on enhancement and image quality for triple‐phase helical computed tomography of the liver in small dogs
Authors: Lee Sang‐Kwon , Lee Dahae , Kim Dongeun , Cha Ahyoung , Choi Jihye 
Published: July 2017

AbstractRapid contrast injection is recommended for triple‐phase helical computed tomography (CT) of the liver. However, a large‐gauge catheter is needed for faster contrast injection and this is not practical for small breed dogs or cats. The purpose of this crossover group study was to evaluate applicability of a lower injection rate with a small‐gauge (G) catheter for triple‐phase hepatic CT in small dogs. Triple‐phase CT images were acquired for six beagle dogs using three protocols: an injection rate of 1.5 ml/s with a 24 G catheter, 3.0 ml/s with a 22 G catheter, and 4.5 ml/s with a 20 G catheter. Enhancement of the aorta, portal vein, and hepatic parenchyma was measured in each phase (arterial, portal, and delayed) and image quality was scored subjectively by two observers. Injection duration, time to scan delay, and time to peak enhancement were also recorded. Contrast injection duration decreased with a higher injection rate (n = 6, P ≤ 0.01), but time to peak enhancement and time to scan delay were not significantly affected by injection rates and catheter sizes. Contrast injection rate did not significantly affect aortic, portal, and hepatic enhancement. In addition, separation between each phase and quality of images was subjectively scored as good regardless of injection rate. Findings from the current study supported using an injection rate of 1.5 ml/s with a catheter size of 24 G for triple‐phase hepatic CT in small dogs (weight < 12 kg).
Complete Genome Sequence of Bacillus horikoshii Strain 20a from Cuatro Cienegas, Coahuila, Mexico
Authors: Zarza Eugenia , Alcaraz Luis D. , Aguilar-Salinas Bernardo , Islas Africa , Olmedo-Álvarez Gabriela 
Published: July 2017

ABSTRACT

We sequenced the
Bacillus horikoshii
20a genome, isolated from sediment collected in Cuatro Cienegas, Mexico. We identified genes involved in establishing antagonistic interactions in microbial communities (antibiotic resistance and bacteriocins) and genes related to the metabolism of cyanophycin, a reserve compound and spore matrix material potentially relevant for survival in an oligotrophic environment.
Draft Genome Sequences of 43
Lactobacillus
Strains from the Species
L. curvatus
,
L. fermentum
,
L. paracasei
,
L. plantarum
, L. rhamnosus, and
L. sakei
, Isolated from Food Products
Authors: Inglin Raffael C. , Meile Leo , Stevens Marc J. A. 
Published: July 2017

ABSTRACT

The genome sequences of 43
Lactobacillus
strains from the species
L. curvatus
,
L. fermentum
,
L. paracasei
,
L. plantarum
,
L. rhamnosus
, and
L. sakei
were determined using Illumina MiSeq.
Draft Genome Sequence of
Rathayibacter
sp. Strain VKM Ac-2630 Isolated from Leaf Gall Induced by the Knapweed Nematode
Mesoanguina picridis
on
Acroptilon repens
Authors: Starodumova Irina P. , Tarlachkov Sergey V. , Prisyazhnaya Natalia V. , Dorofeeva Lubov V. , Ariskina Elena V. , Chizhov Vladimir N. , Subbotin Sergei A. , Evtushenko Lyudmila I. , Vasilenko Oleg V. 
Published: July 2017

ABSTRACT

A draft genome sequence of
Rathayibacter
sp. strain VKM Ac-2630 was derived using Ion Torrent sequencing technology. The genome size of this strain is 3.88 Mb, with an average G+C content of 72.0%. Genomic evidence of an aerobic mode of respiration and a heterotrophic lifestyle of this bacterium was obtained.
Genome Sequence of Leuconostoc mesenteroides LK-151 Isolated from a Japanese Sake Cellar as a High Producer of
d
-Amino Acids
Authors: Kato Shiro , Oikawa Tadao 
Published: July 2017

ABSTRACT

Here, we report the complete genome sequence of strain LK-151 of
Leuconostoc mesenteroides
, which was isolated from a Japanese sake cellar and has the potential to produce large amounts of
d
-amino acids, namely,
d
-Ala and
d
-Glu. The genome contains 4 genes related to
d
-amino acid production.
Microbiomes of American Oysters (
Crassostrea virginica
) Harvested from Two Sites in the Chesapeake Bay
Authors: Ossai Sylvia , Ramachandran Padmini , Ottesen Andrea , Reed Elizabeth , DePaola Angelo , Parveen Salina 
Published: July 2017

ABSTRACT

In this study, we used 16S rRNA gene amplicons to describe the bacterial microbiota associated with oysters (
Crassostrea virginica
) and seawater collected from two sites in the Chesapeake Bay. The dominant bacterial groups included those belonging to the order
Pelagibacteraceae
, family
Enterobacteriaceae
, and genus
Synechococcus
. The microbiomes varied among oysters from the same site and between the two sites and months.
Complete Genome Sequence of Campylobacter jejuni subsp.
jejuni
ATCC 35925
Authors: Gardner Susan P. , Kendall Kevin J. , Taveirne Michael E. , Olson Jonathan W. 
Published: July 2017

ABSTRACT

Here, we report the complete genome sequence of
Campylobacter jejuni
ATCC 35925, an avian isolate from Sweden. The genome gives insight into the ATCC 35925 strain’s remarkable ability to tolerate copper and its permissiveness to plasmid transformation.
A Matter of Scale and Dimensions: Chromatin of Chromosome Landmarks in the Fungi
Authors: Erlendson Allyson A. , Friedman Steven , Freitag Michael 
Published: July 2017

ABSTRACT

Chromatin and chromosomes of fungi are highly diverse and dynamic, even within species. Much of what we know about histone modification enzymes, RNA interference, DNA methylation, and cell cycle control was first addressed in
Saccharomyces cerevisiae
,
Schizosaccharomyces pombe
,
Aspergillus nidulans
, and
Neurospora crassa
. Here, we examine the three landmark regions that are required for maintenance of stable chromosomes and their faithful inheritance, namely, origins of DNA replication, telomeres and centromeres. We summarize the state of recent chromatin research that explains what is required for normal function of these specialized chromosomal regions in different fungi, with an emphasis on the silencing mechanism associated with subtelomeric regions, initiated by sirtuin histone deacetylases and histone H3 lysine 27 (H3K27) methyltransferases. We explore mechanisms for the appearance of “accessory” or “conditionally dispensable” chromosomes and contrast what has been learned from studies on genome-wide chromosome conformation capture in
S. cerevisiae
,
S. pombe
,
N. crassa
, and
Trichoderma reesei
. While most of the current knowledge is based on work in a handful of genetically and biochemically tractable model organisms, we suggest where major knowledge gaps remain to be closed. Fungi will continue to serve as facile organisms to uncover the basic processes of life because they make excellent model organisms for genetics, biochemistry, cell biology, and evolutionary biology.
Herbal medications for surgical patients: a systematic review protocol
Authors: Arruda Ana Paula Nappi , Ayala Ana Patricia , Lopes Luciane C , Bergamaschi Cristiane C , Guimarães Caio , Grossi Mariana Del , Righesso Leonardo A R , Agarwal Arnav , Dib Regina El 
Published: July 2017

IntroductionPostoperative nausea and vomiting (PONV) affect approximately 80% of surgical patients and is associated with increased length of hospital stay and systemic costs. Preoperative and postoperative pain, anxiety and depression are also commonly reported. Recent evidence regarding their safety and effectiveness has not been synthesised. The aim of this systematic review is to evaluate the efficacy and safety of herbal medications for the treatment and prevention of anxiety, depression, pain and PONV in patients undergoing laparoscopic, obstetrical/gynaecological and cardiovascular surgical procedures.Methods and analysisThe following electronic databases will be searched up to 1 October 2016 without language or publication status restrictions: CENTRAL, MEDLINE, EMBASE, CINAHL, Web of Science and LILACS. Randomised clinical trials enrolling adult surgical patients undergoing laparoscopic, obstetrical/gynaecological and cardiovascular surgeries and managed with herbal medication versus a control group (placebo, no intervention or active control) prophylactically or therapeutically will be considered eligible. Outcomes of interest will include the following: anxiety, depression, pain, nausea and vomiting. A team of reviewers will complete title and abstract screening and full-text screening for identified hits independently and in duplicate. Data extraction, risk of bias assessments and evaluation of the overall quality of evidence for each relevant outcome reported will be conducted independently and in duplicate using the Grading of Recommendations Assessment Development and Evaluation classification system. Dichotomous data will be summarised as risk ratios; continuous data will be summarised as standard average differences with 95% CIs.Ethics and disseminationThis is one of the first efforts to systematically summarise existing evidence evaluating the use of herbal medications in laparoscopic, obstetrical/gynaecological and cardiovascular surgical patients. The findings of this review will be disseminated through peer-reviewed publications and conference presentations.Systematic review registrationPROSPERO CRD42016042838.
Liver allograft biopsies with histological cholestasis: a clinicopathological study of 254 cases from a single centre
Authors: Lo Regina Cheuk-lam , Chan Kristy Kwan-shuen , Chok Kenneth Siu-ho , Ng Irene Oi-lin 
Published: July 2017

AimsLiver allograft biopsy is important in the management of liver transplant (LT) recipients. Cholestasis is an indicator of liver dysfunction, and histological evidence of cholestasis can be observed in a wide range of pathological entities in the post-LT setting. In this study, we describe the clinicopathological features and significance of liver allograft biopsies with histological cholestasis over 11 years in our centre.MethodsLiver allograft biopsies performed in Queen Mary Hospital, Hong Kong from 2004 to 2014 showing histological cholestasis were retrieved from the pathology archive. Clinical and pathological data were retrospectively reviewed and analyzed.ResultsAmong the 254 biopsies from 167 patients, large duct obstruction (LDO) and acute cellular rejection (ACR) were the two main aetiologies associated with cholestasis. There was a decrease in sepsis as a cause over the study duration. In cases showing cholestasis at 6 months or more after LT, LDO was more common than ACR. Over half (61%) of the 254 biopsies showed mild cholestasis. Severe panacinar cholestasis was more often observed in LDO. Mild cholestasis was most commonly observed regardless of the severity of ACR. Severe cholestasis was associated with poorer 1-year and 3-year graft survival and patient survival, as well as higher 3-month and 6-month post-biopsy mortality.ConclusionHistological cholestasis and its severity in liver allograft biopsies has clinical and prognostic significance. Our study summarizes our previous experience and provides further insights into the management of post-LT patients.
Physical activity patterns and socio-demographic correlates of physical activity among medical undergraduates in Sri Lanka: an observational study
Authors: Medagama Arjuna , Galgomuwa Manoj , De Silva Chinthani 
Published: July 2017

AbstractBackgroundPhysical inactivity is the fourth leading risk factor for mortality worldwide and a leading risk factor for type 2 diabetes and cardiovascular disease. Medical undergraduates are a group of young adults expected to have a sound knowledge of the benefits of physical activity (PA) and have an active lifestyle.ObjectiveTo quantifyPA levels among medical undergraduates of a Sri Lankan university and to determine the socio-demographic correlates of physical inactivity.MethodsMedical undergraduates in their third, fourth and fifth years of study were recruited for this quantitative, descriptive, cross-sectional study using a self-administered questionnaire.ResultsA total of 421 students were recruited. Overall 41% were physically inactive. Females (47%) were more inactive than males (34%). The total mean weekly metabolic equivalent (MET)-minutes was 1468.2±1873. Males (1676.2±1629) had a higher mean weekly MET minutes than females (1319±20102), p=0.05. 88% owned a portable internet device such as a smartphone or tablet. Students using health-related apps on their devices had significantly higherPA (p=0.01) and lower body mass index (BMI) (p=0.04), than those who did not. Binary logistic regression revealed physical inactivity to be significantly associated with gender (p=0.01), not using a health-promoting app on their portable device (p=0.01) and the year of study (p=0.03).ConclusionPhysical inactivity is a significant problem among medical undergraduates. The use of health applications was associated with a higher PA and lower BMI. The reasons for inactivity and the discrepancy in activity levels between males and females needs to be explored in greater detail.
MPEG column: 117th MPEG Meeting
Authors: Timmerer Christian 
Published: July 2017

The 117th MPEG meeting was held in Geneva, Switzerland and its press release highlights the following aspects:
•MPEG issues Committee Draft of the Omnidirectional Media Application Format (OMAF)
•MPEG-H 3D Audio Verification Test Report
•MPEG Workshop on 5-Year Roadmap Successfully Held in Geneva
•Call for Proposals (CfP) for Point Cloud Compression (PCC)
•Preliminary Call for Evidence on video compression with capability beyond HEVC
•MPEG issues Committee Draft of the Media Orchestration (MORE) Standard
•Technical Report on HDR/WCG Video Coding
JPEG column: 74th JPEG meeting
Authors: Pinheiro Antonio 
Published: July 2017

The 74th JPEG meeting was held at ITU Headquarters in Geneva, Switzerland, from 15 to 20 January featuring the following highlights:
•A Final Call for Proposals on JPEG Pleno was issued focusing on light field coding;
•Creation of a test model for the upcoming JPEG XS standard;
•A draft Call for Proposals for JPEG Privacy & Security was issued;
•JPEG AIC technical report finalized on Guidelines for image coding system evaluation;
•An AHG was created to investigate the evidence of high throughput JPEG 2000;
•An AHG on next generation image compression standard was initiated to explore a future image coding format with superior compression efficiency.
Toward Precision Radiotherapy for Use with Immune Checkpoint Blockers
Authors: Vanpouille-Box Claire , Formenti Silvia C. , Demaria Sandra 
Published: July 2017

Abstract
The first evidence that radiotherapy enhances the efficacy of immune checkpoint blockers (ICB) was obtained a dozen years ago in a mouse model of metastatic carcinoma refractory to anti–CTLA-4 treatment. At the time, ICBs had just entered clinical testing, an endeavor that culminated in 2011 with the approval of the first anti–CTLA-4 antibody for use in metastatic melanoma patients (ipilimumab). Thereafter, some patients progressing on ipilimumab showed systemic responses only upon receiving radiation to one lesion, confirming clinically the proimmunogenic effects of radiation. Preclinical data demonstrate that multiple immunomodulators synergize with radiotherapy to cause the regression of irradiated tumors and, less often, nonirradiated metastases. However, the impact of dose and fractionation on the immunostimulatory potential of radiotherapy has not been thoroughly investigated. This issue is extremely relevant given the growing number of clinical trials testing the ability of radiotherapy to increase the efficacy of ICBs. Recent data demonstrate that the recruitment of dendritic cells to neoplastic lesions (and hence the priming of tumor-specific CD8+ T cells) is highly dependent on radiotherapy dose and fractionation through a mechanism that involves the accumulation of double-stranded DNA in the cytoplasm of cancer cells and consequent type I IFN release. The molecular links between the cellular response to radiotherapy and type I IFN secretion are just being uncovered. Here, we discuss the rationale for an optimized use of radiotherapy as well as candidate biomarkers that may predict clinical responses to radiotherapy combined with ICBs. Clin Cancer Res; 24(2); 259–65. ©2017 AACR.
Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen through ERα Reexpression
Authors: Anbalagan Muralidharan , Sheng Mei , Fleischer Brian , Zhang Yifang , Gao Yuanjun , Hoang Van , Matossian Margarite , Burks Hope E. , Burow Matthew E. , Collins-Burow Bridgette M. , Hangauer David , Rowan Brian G. 
Published: July 2017

Abstract
Unlike breast cancer that is positive for estrogen receptor-α (ERα), there are no targeted therapies for triple-negative breast cancer (TNBC). ERα is silenced in TNBC through epigenetic changes including DNA methylation and histone acetylation. Restoring ERα expression in TNBC may sensitize patients to endocrine therapy. Expression of c-Src and ERα are inversely correlated in breast cancer suggesting that c-Src inhibition may lead to reexpression of ERα in TNBC. KX-01 is a peptide substrate–targeted Src/pretubulin inhibitor in clinical trials for solid tumors. KX-01 (1 mg/kg body weight-twice daily) inhibited growth of tamoxifen-resistant MDA-MB-231 and MDA-MB-157 TNBC xenografts in nude mice that was correlated with Src kinase inhibition. KX-01 also increased ERα mRNA and protein, as well as increased the ERα targets progesterone receptor (PR), pS2 (TFF1), cyclin D1 (CCND1), and c-myc (MYC) in MDA-MB-231 and MDA-MB-468, but not MDA-MB-157 xenografts. MDA-MB-231 and MDA-MB-468 tumors exhibited reduction in mesenchymal markers (vimentin, β-catenin) and increase in epithelial marker (E-cadherin) suggesting mesenchymal-to-epithelial transition (MET). KX-01 sensitized MDA-MB-231 and MDA-MB-468 tumors to tamoxifen growth inhibition and tamoxifen repression of the ERα targets pS2, cyclin D1, and c-myc. Chromatin immunoprecipitation (ChIP) of the ERα promoter in KX-01–treated tumors demonstrated enrichment of active transcription marks (acetyl-H3, acetyl-H3Lys9), dissociation of HDAC1, and recruitment of RNA polymerase II. Methylation-specific PCR and bisulfite sequencing demonstrated no alteration in ERα promoter methylation by KX-01. These data demonstrate that in addition to Src kinase inhibition, peptidomimetic KX-01 restores ERα expression in TNBC through changes in histone acetylation that sensitize tumors to tamoxifen.
Implications: Src kinase/pretubulin inhibitor KX-01 restores functional ERα expression in ERα– breast tumors, a novel treatment strategy to treat triple-negative breast cancer. Mol Cancer Res; 15(11); 1491–502. ©2017 AACR.
Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity
Authors: van den Heuvel Corina N.A.M. , Navis Anna C. , de Bitter Tessa , Amiri Houshang , Verrijp Kiek , Heerschap Arend , Rex Karen , Dussault Isabelle , Caenepeel Sean , Coxon Angela , Span Paul N. , Wesseling Pieter , Hendriks Wiljan , Leenders William P.J. 
Published: July 2017

Abstract
The receptor tyrosine kinase (RTK) MET represents a promising tumor target in a subset of glioblastomas. Most RTK inhibitors available in the clinic today, including those inhibiting MET, affect multiple targets simultaneously. Previously, it was demonstrated that treatment with cabozantinib (MET/VEGFR2/RET inhibitor) prolonged survival of mice carrying orthotopic patient-derived xenografts (PDX) of the MET-addicted glioblastoma model E98, yet did not prevent development of recurrent and cabozantinib-resistant tumors. To exclude VEGFR2 inhibition-inflicted blood–brain barrier normalization and diminished tumor distribution of the drug, we have now investigated the effects of the novel MET-selective inhibitor Compound A in the orthotopic E98 xenograft model. In vitro, Compound A proved a highly potent inhibitor of proliferation of MET-addicted cell lines. In line with its target selectivity, Compound A did not restore the leaky blood–brain barrier and was more effective than cabozantinib in inhibiting MET phosphorylation in vivo. Compound A treatment significantly prolonged survival of mice carrying E98 tumor xenografts, but did not prevent eventual progression. Contrasting in vitro results, the Compound A–treated xenografts displayed high levels of AKT phosphorylation despite the absence of phosphorylated MET. Profiling by RNA sequencing showed that in vivo transcriptomes differed significantly from those in control xenografts.
Implications: Collectively, these findings demonstrate the plasticity of paracrine growth factor receptor signaling in vivo and urge for prudency with in vitro drug-testing strategies to validate monotherapies. Mol Cancer Res; 15(11); 1587–97. ©2017 AACR.