bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eighteen‐Months Safety and Efficacy Following Intraperitoneal Treatment With 224Radium‐Labeled Microparticles After CRS‐HIPEC in Patients With Peritoneal Metastasis From Colorectal Cancer
Authors: Larsen S. G. , Graf W. , Larsen R. H. , Revheim M.‐E. , Mariathasan A. M. , Sørensen O. , Spasojevic M. , Rashid G. , Lundstrøm N. , Gjertsen T. J. , Aksnes A.‐K. , Bruland Ø. S. 
Published: October 2024

ABSTRACTBackground and ObjectivesPeritoneal metastasis from colorectal cancer carries a high risk for relapse after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC). A novel alpha‐emitting radiopharmaceutical (Radspherin) has been designed to deliver short‐range radiation to micrometastases and free‐floating tumor cells.MethodsA Phase 1/2a study evaluated the safety, tolerability, and signal of efficacy of escalating doses of Radspherin injected intraperitoneally after CRS‐HIPEC.ResultsEleven patients received 1−4 MBq (Group 1) whereas 12 patients received 7 MBq; nine patients single dose/three patients split‐dose (Group 2). Median age was 66.5 and 61.5 years, and median peritoneal cancer index 6 and 7, respectively. One hundred and seventy‐eight adverse events were reported, only seven were deemed related to Radspherin. Thirteen serious adverse events (SAEs) were reported in eight patients and no SAEs were related to Radspherin. At 18‐months, none of the 12 patients receiving 7 MBq experienced peritoneal recurrences, however four had non‐peritoneal recurrences. Across both groups (n = 22), 41% had recurrent disease, only 14% of them in the peritoneum.ConclusionsRadspherin was well tolerated. At 18 months, median disease‐free survival has not been reached, and none of the patients receiving the recommended dose (7 MBq) had peritoneal recurrences. The results are encouraging and warrant further clinical evaluation.
Combining RNA tape stripping with dermoscopic features for melanoma identification
Authors: von Knorring Terese , Heerfordt Ida M. , Andersen Jeppe D. , Rosenkrantz Hølmich Lisbet , Karmisholt Katrine , Omland Silje H. , Knudsen Frederikke F. , Philipsen Peter A. , Mogensen Mette 
Published: October 2024

AbstractBackgroundA noninvasive, accurate diagnostic method for melanoma is needed to improve early detection and decrease number of excisions. Gene expression as measured by RNA levels uses tape strips to directly assesses genetic markers from skin lesions. Commercial RNA assays show varying diagnostic accuracy in melanoma detection. Combining dermoscopic features with RNA tape strips could reduce unnecessary removal of benign lesions by increasing specificity.ObjectivesTo test an RNA‐based rule‐out test and integrate dermoscopic features with RNA analysis to improve diagnostic accuracy of malignant melanoma (MM). Furthermore, we explore the association between RNA profiles and dermoscopic features.MethodsSeventy patients with pigmented skin lesions suspected of being melanoma were imaged with dermoscopy and tape stripped for RNA analysis before surgical excision. The images were evaluated for seven dermoscopic features, and RNA levels of 11 genes were analyzed. A combined test using both gene expression and dermoscopic features was developed. Associations between RNA profiles and dermoscopic features were explored.ResultsHistopathology revealed 19 malignant lesions (17 MM and two basal cell carcinomas) and 51 benign lesions. The combined dermoscopy and RNA test identified all malignant lesions (100% sensitivity) based on PRAME expression, blotch and regression structures and patient age. This combined model increased specificity to 35%, compared to 24% with the original RNA rule‐out test, without missing any malignant lesions. Significant differences in RNA profiles were observed for lesions expressing atypical network and regression structures.ConclusionsCombining RNA tape stripping with dermoscopic features can reduce the removal of benign lesions by over one‐third while maintaining 100% sensitivity. We found specific RNA profiles to be strongly associated with dermoscopic features, presenting a promising opportunity to integrate molecular and morphological information and provide valuable guidance for dermatologists managing atypical pigmented lesions.
The Potential Application of Mung Bean (Vigna radiata L.) Protein in Plant‐Based Food Analogs: A Review
Authors: Tarahi Mohammad 
Published: October 2024

ABSTRACTThe increasing demand for plant‐based food products by consumers along with the growing global population requires the discovery of novel and sustainable protein sources to address environmental challenges and meet nutritional requirements. Among various plant proteins, mung bean protein (MBP) exhibits several unique characteristics that make it a valuable ingredient in the field of plant‐based food analogs. This literature review aims to express the unique structure and composition of MBP, in addition to its physicochemical, functional, and nutritional properties. Furthermore, its potential applications in novel meat, dairy, and egg analogs are highlighted to meet the growing demand for sustainable, nutritious, and delicious plant‐based food alternatives. Structurally, MBP consists of a complex arrangement of amino acids, forming a globular protein with distinct functional properties. Its composition is also rich in essential amino acids, particularly leucine and lysine, making it a promising protein source for plant‐based diets. From a techno‐functional perspective, MBP exhibits remarkable gelling, emulsifying, foaming, and binding properties, which are necessary for the development of stable emulsions, airy foams, firm gels, and cohesive textures in various plant‐based food formulations. Moreover, MBP and its derivatives can possess notable bio‐functional properties, including antioxidant activity and anti‐inflammatory benefits, as well as cholesterol‐lowering, anti‐obesity, antidiabetic, antihypertensive, and anticancer effects. Consequently, the production of food analogs based on MBP not only improves the techno‐functional attributes of the final products but also can promote consumer health and well‐being.
Medication Use and Treatment Indications in Huntington's Disease; Analyses from a Large Cohort
Authors: Feleus Stephanie , Skotnicki Lara E.M. , Roos Raymund A.C. , de Bot Susanne T. 
Published: October 2024

AbstractBackgroundHuntington's Disease is a rare neurodegenerative disorder in which appropriate medication management is essential. While many medications are prescribed based on expert knowledge, overviews of actual medication use in HD are sparse.ObjectivesWe provide a detailed overview of medication use and associated indications across HD disease stages, considering sex and regional differences.MethodsData from the largest observational HD study, ENROLL‐HD, were used. We created HD‐related medication and indication classes to identify medication trends in manifest, premanifest and control subjects. We studied medication use in adult, childhood‐ and adolescent‐onset HD, incorporating disease stage (including phenoconverters), sex and regional differences.ResultsIn 8546 manifest HD patients, 84.6% used medication (any type), with the average number of medications per user rising from 2.5 in premanifest HD to 5.2 in end stage disease. Antipsychotics (29.2%), SSRIs (27.5%) and painkillers (21.8%) were most often used. Medication use varied with disease progression. Several differences were observed between the sexes, and notably between Europe and Northern America as well. Medication use increased after phenoconversion (from 64.8% to 70.6%, P < 0.05), with the largest difference in antipsychotic use (4.4%–7.8%, P < 0.05). Medication patterns were different in childhood‐onset HD, with no use of painkillers, less use of anti‐chorea and antidepressant drugs, and more for aggression and irritability.ConclusionsMedication use in HD increases with disease progression, with varying types of medications prescribed based on disease stage, sex, and region of living. Recognizing these medication trends is vital for further personalized HD management.
Accelerated cardiac cine with spatio‐coil regularized deep learning reconstruction
Authors: Demirel Omer Burak , Ghanbari Fahime , Morales Manuel Antonio , Pierce Patrick , Johnson Scott , Rodriguez Jennifer , Street Jordan Amy , Nezafat Reza 
Published: October 2024

AbstractPurposeTo develop an iterative deep learning (DL) reconstruction with spatio‐coil regularization and multichannel k‐space data consistency for accelerated cine imaging.MethodsThis study proposes a Spatio‐Coil Regularized DL (SCR‐DL) approach for iterative deep learning reconstruction incorporating multicoil information in data consistency and regularizer. SCR‐DL uses shift‐invariant convolutional kernels to interpolate missing k‐space lines and reconstruct individual coil images, followed by a regularizer that operates simultaneously across spatial and coil dimensions using learned image priors. At 8‐fold acceleration, SCR‐DL was compared with Generalized Autocalibrating Partially Parallel Acquisition (GRAPPA), sensitivity encoding (SENSE)‐based DL and spatio‐temporal regularized (STR)–DL reconstruction. In the retrospective undersampled cine, images were quantitatively evaluated using normalized mean square error (NMSE) and structural similarity index measure (SSIM). Additionally, agreement for left‐ventricular ejection fraction and left‐ventricular mass were assessed using prospectively accelerated cine images at 2‐fold and 8‐fold accelerations.ResultsThe SCR‐DL algorithm successfully reconstructed highly accelerated cine images. SCR‐DL had significant improvements in NMSE (0.03 ± 0.02) and SSIM (91.4% ± 2.7%) compared with GRAPPA (NMSE: 0.09 ± 0.04, SSIM: 69.9% ± 11.1%; p < 0.001), SENSE‐DL (NMSE: 0.07 ± 0.04, SSIM: 86.9% ± 3.2%; p < 0.001), and STR‐DL (NMSE: 0.04 ± 0.03, SSIM: 90.0% ± 2.5%; p < 0.001) with retrospective undersampled cine. Despite the 3‐fold reduction in scan time, there was no difference between left‐ventricular ejection fraction (59.8 ± 4.5 vs. 60.8 ± 4.8, p = 0.46) or left‐ventricular mass (73.6 ± 19.4 g vs. 73.2 ± 19.7 g, p = 0.95) between R = 2 and R = 8 prospectively accelerated cine images.ConclusionsSCR‐DL enabled highly accelerated cardiac cine imaging, significantly reducing breath‐hold time. Compared with GRAPPA or SENSE‐DL, images reconstructed with SCR‐DL showed superior NMSE and SSIM.
A 3D fast MR elastography sequence with interleaved multislab acquisition and Hadamard encoding
Authors: Wang Runke , Chen Yu , Yan Fuhua , Yang Guang‐Zhong , Feng Yuan 
Published: October 2024

AbstractPurposesTo enhance the functional capability of MRI, this study aims to develop a novel MR elastography (MRE) sequence that achieves rapid acquisition without distortion artifacts.MethodsA displacement‐encoded stimulated echo (DENSE) with multiphase acquisition scheme was used to capture wave images. A center‐out golden‐angle stack‐of‐stars sampling pattern was introduced for improved SNR and data incoherence. A combination of Hadamard encoding and interleaved multislab acquisition schemes was used to increase the acquisition efficiency of MRE data with multiple directions and phase offsets. A generalized parallel‐imaging and compressed‐sensing method was further applied to accelerate the acquisition process. The imaging results of the proposed sequence were compared with those from six gradient echo (GRE)/EPI/DENSE–based MRE sequences via phantom and brain acquisitions.ResultsThe proposed sequence achieved a 6‐fold acceleration compared with GRE MRE. With the application of a conventional parallel‐imaging and compressed‐sensing algorithm, the scanning speed was further accelerated by 8‐fold, matching the speed of EPI‐based MRE. Phantom tests revealed small variances in stiffness measurements across the seven sequences (< 9.23%). The proposed sequence exhibited a higher contrast‐to‐noise ratio (1.38) than the two EPI‐based sequences (0.61/0.76) and similar to GRE‐based sequences (1.34/1.22/1.58). Brain imaging validated the effectiveness of the proposed sequence in accurate stiffness estimation and distortion artifact avoidance.ConclusionA rapid DENSE‐based MRE sequence with interleaved multislab acquisition and Hadamard encoding was developed at a speed matching EPI‐based sequences, without compromising SNR or introducing distortion artifacts.
Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z‐spectroscopy (UFZ) MRI at 3T
Authors: Ju Licheng , Schär Michael , Wang Kexin , Li Anna , Wu Yihan , Samuel T. Jake , Ganji Sandeep , van Zijl Peter C. M. , Yadav Nirbhay N. , Weiss Robert G. , Xu Jiadi 
Published: October 2024

AbstractPurposeTo investigate the feasibility of rapid CEST MRI acquisition for evaluating oxidative phosphorylation (OXPHOS) in human skeletal muscle at 3T, utilizing ultrafast Z‐spectroscopy (UFZ) combined with MRI and the Polynomial and Lorentzian line‐shape Fitting (PLOF) technique.MethodsUFZ MRI on muscle was evaluated with turbo spin echo (TSE) and 3D EPI readouts. Five healthy subjects performed in‐magnet plantar flexion exercise (PFE) and subsequent changes of amide, PCr, and partial PCr mixed Cr (Cr+) CEST dynamic signals post‐exercise were enabled by PLOF fitting. PCr/Cr CEST signal was further refined through pH correction by using the ratios between PCr/Cr and amide signals, named PCAR/CAR, respectively.ResultsUFZ MRI with TSE readout significantly reduces acquisition time, achieving a temporal resolution of <50 s for collecting high‐resolution Z‐spectra. Following PFE, the recovery/decay times (τ) for both PCr and Cr in the gastrocnemius muscle of the calf were notably longer when determined using PCr/Cr CEST compared to those after pH correction with amideCEST, namely = 87.1 ± 15.8 s and = 98.1 ± 20.4 s versus = 32.9 ± 19.7 s and = 43.0 ± 13.0 s, respectively. obtained via 31P MRS ( = 50.3 ± 6.2 s) closely resemble those obtained from pH‐corrected PCr/Cr CEST signals.ConclusionThe outcomes suggest potential of UFZ MRI as a robust tool for non‐invasive assessment of mitochondrial function in skeletal muscles. pH correction is critical for the reliable OXPHOS measurement by CEST.
Have a Good Travel Time in Routing: Bibliometric Analysis, Literature Review, and Future Directions
Authors: Zhou Guanghui , Bao Xinyue , Luo Jingxian , Bian Junsong 
Published: October 2024

ABSTRACTTravel time serves as a critical factor in routing problems, affecting routing decisions, congestion avoidance, and environmental sustainability. In this study, a thorough bibliometric and network analysis is presented based on 1752 documents collected from Web of Science published in the past three decades. CiteSpace is adopted to generate research clusters for topological analysis that graphically illustrate the publications' evolution over time and identify the current state and the emerging trends of routing problems with travel time focus. The collaboration network explores the cooperation patterns between countries and institutions. Attention toward the time‐dependency, uncertainty, dynamic characteristics of travel time, and the influence of travel speed on emissions, is uncovered through document co‐citation analysis. Furthermore, a comprehensive review of the literature has been conducted from an information quality and evolution perspective. Realistic scenarios such as fuel consumption and traffic conditions are eliciting more attention. Significant emphasis is increasingly placed on the time dependency, reliability, uncertainty, and dynamics of travel time. This study systematically reviews and analyzes relevant research on routing problems with travel time focus, identifying key emerging trends and knowledge gaps, and offering valuable insights for future research.
Association between treatment response and dose of blonanserin transdermal patch in patients with acute schizophrenia: A post hoc cluster analysis based on baseline psychiatric symptoms
Authors: Takekita Yoshiteru , Matsumoto Yuji , Masuda Takahiro , Yoshida Kazumasa , Koshikawa Yosuke , Kato Masaki 
Published: October 2024

AbstractAimTo explore the optimal dose of blonanserin transdermal patch (BNS‐P) based on baseline psychiatric symptomatic characteristics during acute schizophrenia.MethodsA post hoc cluster analysis was conducted using data from a 6‐week randomized, double‐blind, placebo‐controlled study of BNS‐P (40 or 80 mg/day) in acute schizophrenia. We classified patients into three clusters based on baseline psychiatric symptoms. Efficacy was assessed using the change from baseline to week 6 in the PANSS total score. Safety was assessed by the incidence of adverse events.ResultsAmong 577 patients, three clusters were identified, characterized by severe psychiatric (Cluster‐S; n = 122), predominant negative (Cluster‐N; n = 191), and predominant positive (Cluster‐P; n = 264) symptoms. In Cluster‐P, both BNS‐P 40 and 80 mg/day reduced PANSS total score significantly more than placebo (p = 0.036, effect size = 0.342; p < 0.001, effect size = 0.687, respectively). In Cluster‐S and ‐N, only BNS‐P 80 mg/day reduced PANSS total score significantly more than placebo (p = 0.045, effect size = 0.497; p = 0.034, effect size = 0.393, respectively). The effect size was greater at 80 mg/day than at 40 mg/day across all clusters. The most common treatment‐emergent adverse events were akathisia and skin‐related adverse events in all clusters.ConclusionBNS‐P exhibited a dose‐dependent antipsychotic effect in all clusters, particularly highlighting its efficacy in patients with predominant positive symptoms, even at lower doses. These findings provide novel and valuable insights for determining BNS‐P dose tailoring to individual symptomatic characteristics in real‐world practice.
Association of inpatient and outpatient pediatric palliative care with healthcare utilization and end‐of‐life outcomes in pediatric oncology
Authors: Shamah Rebecca L. , George Elizabeth , DeGroote Nicholas P. , Wasilewski Karen , Brock Katharine E. 
Published: October 2024

AbstractBackgroundPediatric palliative care (PPC) is associated with improved end‐of‐life (EOL) outcomes. Inpatient and outpatient PPC have unique roles during the disease course. Yet, it is unknown whether the location of PPC receipt (inpatient vs. outpatient) is associated with healthcare utilization and EOL outcomes for pediatric and adolescent and young adult oncology patients.ProcedureA retrospective single‐institution chart review of pediatric patients (age 0–28) with cancer who died between January 2015 and December 2022 was performed to compare EOL outcomes and healthcare utilization metrics among inpatient PPC, any outpatient PPC, and non‐PPC recipients. Demographics and clinical factors were analyzed by PPC receipt location.ResultsAmong 450 patients, 292 (64.9%) received PPC (inpatient only 35%, any outpatient 65%). Patients who died without receiving PPC dropped from 69% to 22% following development of an outpatient PPC clinic (p < .001). In the last 6 months, 1 month, and last week of life, inpatient PPC recipients spent more days admitted to the hospital and intensive care unit (all p < .001), and had more intensive medical interventions performed (p < .01). Outpatient PPC recipients were less likely to receive intravenous (IV) chemotherapy (p < .01) or intubation (p = .05), and more likely to receive hospice, die at home, and have an outpatient do‐not‐resuscitate order (all p < .001).ConclusionsPPC receipt substantially increased after the creation of an outpatient PPC clinic, suggesting that outpatient PPC is critical in the provision of PPC to children with cancer. Outpatient PPC was associated with fewer hospital days, IV chemotherapy, and intubation at EOL, while increasing hospice enrollment and home death.
Enhancement of pin‐bearing behavior of pultruded FRP profiles by multi‐directional fiber architecture design
Authors: Zhang Leizhi , Wang Xin , Liu Jialin , Liu Xia , Wu Zhishen 
Published: October 2024

AbstractThe low resistance of bolted joints in pultruded unidirectional (UD) fiber‐reinforced polymer (FRP) profiles limits the load grade of truss bridges due to shear damage along UD fibers. To address this issue, this study proposes multi‐directional (MD) fiber architecture in FRP profiles to improve the ultimate bearing strength of bolted joints. The digital image correlation shows that the addition of off‐axis fibers in MD FRP profiles prevents shear failure in the UD FRP profile. As a result, the ultimate bearing strengths of MD FRP profiles are enhanced attributed to “off‐axis fiber tie action”. Micro‐computed tomography shows that fiber damage in MD FRP profiles emerged from outer plies, including fiber breakage in 90° and ±45° fibers and fiber kinking in 0° and ±45° fibers. The off‐axis fibers break due to tension when resisting the bearing load in MD FRP profiles. The fiber kinking indicated strength contribution from 0° to ±45° fibers. The fiber breakage and fiber kinking in each ply are dominant in bearing failure instead of delamination, which increases the bearing strength of the pultruded MD FRP profiles. These findings facilitate controlling damage evolution in the pultruded MD FRP profiles and designing high‐resistance bolted joints.Highlights
Multi‐directional fibers improved bearing strengths of FRP profiles by 28.5%–33%.
Off‐axis fibers bent under pin‐bearing, forming a tie action until breakage.
Fiber breakage and kinking in each ply contributed to the bearing failure.
Strain localization and redistribution were observed using DIC.
Exfoliation of boron nitride nanosheets by liquid phase method based on deep eutectic solvents and their thermal management application
Authors: Tong Xin , Zou Yangming , Dong Xinxin , Li Hongfei , Gu Xiaoyu , Sun Jun , Zhang Sheng 
Published: October 2024

AbstractBoron nitride had emerged as an innovative thermally conductive filler, garnering increasing attention from researchers. However, there was a need to create new methods for efficiently producing functionalized boron nitride nanosheets with enhanced thermal conductivity and dispersion. In this study, a novel approach was introduced to utilize deep eutectic solvents as additives to facilitate the exfoliation of boron nitride nanosheets. This method offered significant advantages in terms of cost‐effectiveness (low additives level) and high yield (about 60%). Furthermore, the resulting epoxy resin composite material exhibited outstanding thermal conductivity and thermal management properties. The thermal conductivity of EP/d‐BNNS composites reached 1.02 W/mK at 20 wt% d‐BNNS loading. Additionally, the composite material demonstrated good thermal stability and low dielectric properties. This work demonstrated that this proposed approach represents an effective means for the scalable production of boron nitride nanosheets.Highlights
The boron nitride nanosheets were obtained by deep eutectic solvents (DES) ball milling method.
The exfoliated boron nitride exhibits superior dispersion stability.
The thermal conductivity of EP composites is significantly improved.