bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Route to the Smallest Doped Semiconductor: Mn2+‐Doped (CdSe)13 Clusters.
Authors: Bacher Gerd , et al.  
Published: January 2016

AbstractMn2+‐doped (CdSe)13 clusters are produced in large scale by heating a mixture of CdCl2 and MnCl2 (10:1) in octylamine (120 °C, 2 h) before adding an octylammonium selenocarbamate solution (25 °C, 40 h).
ChemInform Abstract: Low‐Temperature Synthesis of Cu2CoSnS4 Nanoparticles by Thermal Decomposition of Metal Precursors and the Study of Its Structural, Optical and Electrical Properties for Photovoltaic Applications.
Authors: Krishnaiah Mokurala , Bhargava Parag , Mallick Sudhanshu 
Published: January 2016

AbstractCu2CoSnS4 (CCTS) nanoparticles are prepared from a 1.85:1:1:12 molar mixture of Cu(OAc)2, CoCl2, SnCl2, and CS(NH)2 in EtOH which is ball milled prior to thermal decomposition (alumina crucible, 250‐450 °C, 1‐6 h).
ChemInform Abstract: Efficient and Inexpensive Sodium—Magnesium Hybrid Battery.
Authors: Walter Marc , Kravchyk Kostiantyn V. , Ibanez Maria , Kovalenko Maksym V. 
Published: January 2016

AbstractA hybrid intercalation battery based on a NaBH4/Mg(BH4)2 dual salt electrolyte in diglyme, metallic Mg anode, and a cathode based on FeS2 nanocrystals is constructed.
ChemInform Abstract: Bismuth Based Hybrid Perovskites A3Bi2I9 (A: Methylammonium or Cesium) for Solar Cell Application.
Authors: Park Byung‐Wook , Philippe bertrand , Zhang Xiaoliang , Rensmo Hakan , Boschloo Gerrit , Johansson Erik M. J. 
Published: January 2016

AbstractIn view of the possible replacement of toxic lead perovskites in solar cells by a less toxic electrode material, Bi‐based perovskites A3Bi2I9 (A: MeNH3, Cs) are synthesized by reaction of metallic Cs or MeNH3I with BiI3 in a 7:3 DMF/DMSO mixture.
ChemInform Abstract: A Novel Visible Light‐Driven Silver Isocyanate Photocatalyst: Superior Stability Enhanced by Intrinsic Resonance Effect.
Authors: Fan Shuo , Chen Gang , Li Chunmei , Lv Chade , Han Zhonghui , Rao Jiancun , Hu Yidong , Zhang Congmin 
Published: January 2016

AbstractAgNCO is precipitated from an aqueous urea solution of AgNO3 (2 h, darkness).
ChemInform Abstract: Intermolecular versus Intramolecular Palladium‐Catalyzed Direct Arylations Between 1‐(2‐Bromobenzyl)imidazoles and Aryl Bromides.
Authors: Xu Xiaowen , Zhao Liqin , Li Yiqun , Soule Jean‐Francois , Doucet Henri 
Published: January 2016

Abstractas a route to polycyclic imidazoles and fused azepine derivatives
ChemInform Abstract: Catalytic Enantioselective 1,4‐Iodofunctionalizations of Conjugated Dienes.
Authors: Tripathi Chandra Bhushan , Mukherjee Santanu 
Published: January 2016

AbstractTreatment of unsaturated oximes and hydrazones with NIS in the presence of chiral catalysts (I) gives optically active isoxazolines and pyrazolines.
ChemInform Abstract: Rh‐Catalyzed Reagent‐Free Ring Expansion of Cyclobutenones and Benzocyclobutenones.
Authors: Chen Peng‐hao , Sieber Joshua , Senanayake Chris H. , Dong Guangbin 
Published: January 2016

AbstractThe title reaction gives a variety of indanones [e.g. (II)] and poly‐substituted cyclopentenones [e.g. (VIII)] without additional oxidants or reductants.
ChemInform Abstract: Reactions of Tertiary Allylic Amines and Dichlorocarbenes.
Authors: Wang Meili , Xiao Fenfen , Bai Yinjuan , Hu Xiangdong 
Published: January 2016

AbstractThe reaction of tertiary allylic amines with intermediate dichlorocarbenes formed in situ from chloroform affords either formylamides via de‐N‐allylation or dichlorocyclopropane derivatives via addition of CCl2 to the allylic double bond.
ChemInform Abstract: Mononuclear Nonheme Iron(III)‐Iodosylarene and High‐Valent Iron‐Oxo Complexes in Olefin Epoxidation Reactions.
Authors: Wang Bin , Lee Yong‐Min , Seo Mi Sook , Nam Wonwoo 
Published: January 2016

AbstractA non‐heme Fe(III)‐complex, generated from Fe(II)‐complex (ITT) and chiral iodosoarene (CIB) in the presence of HClO4, is successfully applied to the catalytic enantioselective epoxidation of di‐ and trisubstituted α,β‐unsaturated enones.
ChemInform Abstract: Direct Ruthenium‐Catalyzed Hydrogenation of Carboxylic Acids to Alcohols.
Authors: Cui Xinjiang , Li Yuehui , Topf Christoph , Junge Kathrin , Beller Matthias 
Published: January 2016

AbstractAryl, benzyl, and alkylcarboxylic acids endowed with a range of functional groups as well as dicarboxylic acids are efficiently reduced to the corresponding alcohols.
ChemInform Abstract: Electrophilic N‐Trifluoromethylation of N—H Ketimines.
Authors: Zheng Gang , Ma Xiaoli , Li Jiaheng , Zhu Dongsheng , Wang Mang 
Published: January 2016

AbstractTwo novel protocols for the direct N‐trifluoromethylation of ketimines are developed: Ruppert—Prakash reagent (II) (with PhI(OAc)2/KF as promoter) and Togni′s reagent II (VI) (with Cu(OAc)2 as catalyst) are both applied with similar outcomes.
ChemInform Abstract: A Desulfonylative Approach in Oxidative Gold Catalysis: Regiospecific Access to Donor‐Substituted Acyl Gold Carbenes.
Authors: Chen Hongyi , Zhang Liming 
Published: January 2016

AbstractGold‐catalyzed oxidation of alkynyl sulfonamides (I) with pyridine N‐oxides produces acyl gold carbene intermediates by in situ expulsion of sulfur dioxide.
ChemInform Abstract: Silver(I)‐Promoted ipso‐Nitration of Carboxylic Acids by Nitronium Tetrafluoroborate.
Authors: Natarajan Palani , Chaudhary Renu , Venugopalan Paloth 
Published: January 2016

AbstractA novel and efficient method for the regioselective nitration of a series of aliphatic and aromatic carboxylic acids to their corresponding nitro compounds using nitronium tetrafluoroborate and silver carbonate in dimethylacetamide is reported.
ChemInform Abstract: Oxidative Addition of Trifluoroacetamide to Alkenes, 2,5‐Dimethylhexa‐2,4‐diene and Conjugated Cyclic Dienes.
Authors: Shainyan Bagrat A. , Moskalik Mikhail Yu. , Astakhova Vera V. , Sterkhova Irina V. , Ushakov Igor A. 
Published: January 2016

AbstractDepending on the substrates used amidoiodination, amidodiodination, or tandem addition‐cyclization reactions take place selectively.
ChemInform Abstract: Rhodium(III)‐Catalyzed Coupling of Aromatic Ketazines or Oximes with 2‐Vinyloxirane via C—H Activation.
Authors: Wen Jing , Wu An , Miao Yuqin , Zhu Jin 
Published: January 2016

AbstractThe ortho‐selective mono‐coupling proceeds under mild conditions and tolerates diverse substituents.
ChemInform Abstract: A Bioorthogonal Ligation of Cyclopropenones Mediated by Triarylphosphines.
Authors: Shih Hui‐Wen , Prescher Jennifer A. 
Published: January 2016

AbstractRing‐opening of cyclopropenones by amines affords α,β‐unsaturated amides by a novel bioorthogonal ligation between cyclopropenones and phosphines.
ChemInform Abstract: Ultrasound‐Promoted Knoevenagel Condensation Catalyzed by KF‐Clinoptilolite.
Authors: Keipour Hoda , Hosseini Abolfazl , Khalilzadeh Mohammad A. , Ollevier Thierry 
Published: January 2016

AbstractThe cheap and very efficient title reaction of ethyl cyanoacetate or malononitrile with aryl or hetarylaldehydes is described.
ChemInform Abstract: Thermal Reaction of 4‐(p‐Aminophenyl)‐1‐sulfonyl‐1,2,3‐triazoles Furnishing Benzoyl Cyanides Through N‐Sulfinyl Imine Intermediates.
Authors: Miura Tomoya , Zhao Qiang , Funakoshi Yuuta , Murakami Masahiro 
Published: January 2016

AbstractBenzoyl cyanides (II) are prepared by thermolysis of the corresponding sulfonyltriazoles (I).
ChemInform Abstract: Iterative Coupling of Two Different Enones by Nitromethane Using Bifunctional Thiourea Organocatalysts. Stereocontrolled Assembly of Cyclic and Acyclic Structures.
Authors: Varga Szilard , Jakab Gergely , Csampai Antal , Soos Tibor 
Published: January 2016

AbstractVarious unsaturated aldehydes and ketones are utilized for the highly diastereoselective and enantioselective construction of cyclic syn‐ketols and acyclic compounds with multiple contiguous stereocenters.
ChemInform Abstract: Copper‐Catalyzed N‐Benzoylation of Amines via Aerobic C—C Bond Cleavage.
Authors: Fan Wenyou , Yang Youqing , Lei Jianhua , Jiang Qijian , Zhou Wang 
Published: January 2016

Abstract1,2‐Diarylethanones suffer ‐CO‐CH2‐ bond scission under aerobic conditions in the presence of CuCl2 as catalyst enabling the formation of amides with a broad variety of aryl‐, hetaryl‐, and (di)alkylamines in modest to high yields.
ChemInform Abstract: The Insertion of Arynes into the O—H Bond of Aliphatic Carboxylic Acids.
Authors: Wen Chunxiao , Chen Qian , He Zhenwen , Yan Xinxing , Zhang Changyuan , Du Zhiyun , Zhang Kun 
Published: January 2016

AbstractAn efficient O‐arylation of aliphatic carboxylic acids through the insertion of arynes into the O—H bond promoted by sodium carboxylates under mild conditions is developed.
ChemInform Abstract: Assembly of Homoallylamine Derivatives Through Iron‐Catalyzed Three‐Component Sulfonamidoallylation Reaction.
Authors: Fan Xiaohui , Zhu Hong‐Bo , Lv Hao , Guo Kun , Guan Yong‐Hong , Cui Xiao‐Meng , An Bin , Pu Yan‐Ling 
Published: January 2016

AbstractThe title three‐component reaction only applies to aromatic or cinnamylaldehydes [e.g. (I) and (V)], sulfonamides [e.g. (II) and (XI)], and allylsilanes [e.g. (III), (VII), and (IX)], but it doesn′t apply to alkyl aldehydes, ketones, α‐alkylated cinnamylaldehyde, carbamates, or silylalkynes.
ChemInform Abstract: Design of Novel Dispirooxindolopyrrolidine and Dispirooxindolopyrrolothiazole Derivatives as Potential Antitubercular Agents.
Authors: Mhiri Chourouk , Boudriga Sarra , Askri Moheddine , Knorr Michael , Sriram Dharmarajan , Yogeeswari Perumal , Nana Frederic , Golz Christopher , Strohmann Carsten 
Published: January 2016

AbstractTitle compounds [(IV) and (VI)] are synthesized in good yields by three‐component 1,3‐dipolar cycloaddition reactions.
ChemInform Abstract: Enantioselective Synthesis of Functionalized Quaternary Stereocenters.
Authors: Manchoju Amarender , Thorat Rakesh G. , Pansare Sunil V. 
Published: January 2016

AbstractThe target products (V) and (IX) are obtained through a stereoselective Suzuk—Miyaura cross‐coupling reaction giving disubstituted alkylidenemorpholinones (III) and (VIII) followed by a highly stereoselective Prins reaction.
ChemInform Abstract: N‐Heterocyclic Carbene‐Palladium(II)‐1‐Methylimidazole Complex Catalyzed Direct C—H Bond Arylation of Benzo[b]furans with Aryl Chlorides.
Authors: Yin Shun‐Chao , Zhou Quan , Zhao Xiao‐Yun , Shao Li‐Xiong 
Published: January 2016

AbstractFor the first time, sole regioselective C2‐arylation of benzofurans with aryl chlorides using a NHC‐Pd(II) complex as catalyst is achieved.
ChemInform Abstract: 3‐Aza π‐Allyl Palladium Derived from Imino Migration in Palladium‐Carbene: MCRs Toward Multiple Substituted Indole Skeleton.
Authors: Dai Qiang , Jiang Yan , Guo Songjin , Yu Jin‐Tao , Cheng Jiang 
Published: January 2016

AbstractPd‐catalyzed multicomponent reactions of α‐iodoanilines, aryl isonitriles, N‐tosylhydrazones (and solvent) are developed furnishing substituted indole derivatives in good yields.
ChemInform Abstract: Enantioselective Steglich Rearrangement of Oxindole Derivatives by Easily Accessible Chiral N,N‐4‐(Dimethylamino)pyridine Derivatives.
Authors: Mandai Hiroki , Fujiwara Takuma , Noda Katsuaki , Fujii Kazuki , Mitsudo Koichi , Korenaga Toshinobu , Suga Seiji 
Published: January 2016

AbstractThe rearrangement of O‐acylated oxidoles proceeds smoothly in the presence of chiral pyridine catalysts (I) to give oxindole derivatives in excellent yields with enantioselectivities up to 98%.
ChemInform Abstract: Metal‐Free Trifluoroethylation of Activated Alkenes: Rapid Access to Construct Fluorinated 3,3‐Disubstituted 2‐Oxindoles.
Authors: Mai Wen‐Peng , Sun Bin , Qian Guan‐Sheng , Yuan Jin‐Wei , Mao Pu , Yang Liang‐Ru , Xiao Yong‐Mei 
Published: January 2016

AbstractA novel and mild fluorination/cyclization reaction of activated alkenes under metal‐free conditions is reported.
ChemInform Abstract: An Efficient Synthesis of 4‐Isochromanones via Parham‐Type Cyclization with Weinreb Amide.
Authors: Wang Chaolei , Wu Zheng , Wang Jia , Liu Jie , Yao Hequan , Lin Aijun , Xu Jinyi 
Published: January 2016

AbstractThe efficient synthesis of 4‐isochromanones via Parham‐type cyclization proceeds within one minute.
ChemInform Abstract: An Alternative Synthetic Approach to 3‐Alkylated/Arylated 5‐Nitropyridines.
Authors: Le Song Thi , Asahara Haruyasu , Nishiwaki Nagatoshi 
Published: January 2016

AbstractAldehydes react with 1‐methyl‐3,5‐dinitro‐2‐pyridone (I) in the presence of an excess of ammonium acetate as the N source to afford the title compounds via a three‐component ring transformation process.
ChemInform Abstract: MCM‐41 Functionalized with B—F Bond: Preparation, Characterization and Catalytic Application in the Synthesis of Polyhydroquinolines.
Authors: Abdollahi‐Alibeik Mohammad , Rezaeipoor‐Anari Ali 
Published: January 2016

AbstractA one‐pot one‐step transformation of dimedone, aryl aldehydes, ammonium acetate, and β‐keto esters to polyhydroquinolines is described.
ChemInform Abstract: Synthesis of New Chiral Lactam‐Fused Pyridine Derivatives.
Authors: Sengoku Tetsuya , Murata Yusuke , Suzuki Chihiro , Takahashi Masaki , Yoda Hidemi 
Published: January 2016

AbstractThe acid‐promoted cyclization of benzylidene modified tetramic acids with enamines gives chiral C2 symmetric and asymmetric pyridine fused lactams with excellent enantioselectivities.
ChemInform Abstract: Photocycloaddition and Rearrangement Reactions in a Putative Route to the Skeleton of Plicamine‐Type Alkaloids.
Authors: Rimboeck Karl‐Heinz , Poethig Alexander , Bach Thorsten 
Published: January 2016

AbstractIntramolecular [2+2] photocycloaddition of isoquinolones (I) affords the corresponding cyclobutanes containing an exocyclic methylene group with high diastereoselectivity.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Synthesis of δ‐Sultones via α,β‐Unsaturated Sulfonyl Azolium Intermediates.
Authors: Ungureanu Andrei , Levens Alison , Candish Lisa , Lupton David W. 
Published: January 2016

Abstractα,β‐Unsaturated sulfonyl azolium salts, generated in situ from 1,3‐diketone derived silyl enol ethers and NHC‐carbene catalyst (IMes) are developed as novel double bond electrophiles which react with vinyl sulfonyl fluorides to give δ‐sultones in generally moderate yields.
ChemInform Abstract: Aryl λ3‐Iodane‐Mediated 6‐exo‐trig Cyclization to Synthesize Highly Substituted Chiral Morpholines.
Authors: Kishore Vandavasi Jaya , Hu Wan‐Ping , Chandru Senadi Gopal , Chen Hui‐Ting , Chen Hsing‐Yin , Hsieh Kuang‐Chan , Wang Jeh‐Jeng 
Published: January 2016

AbstractA combination of KBr and a phenylalanine‐derived iodane reagent is used for the cyclization of N‐allyl aminoalcohols (I) leading to chiral morpholines (II).
ChemInform Abstract: A Gold‐Catalyzed 1,2‐Acyloxy Migration/Intramolecular Cyclopropanation/Ring Enlargement Cascade: Syntheses of Medium‐Sized Heterocycles.
Authors: Sun Yin‐Wei , Tang Xiang‐Ying , Shi Min 
Published: January 2016

AbstractA highly efficient procedure for the preparation of 10‐ and 11‐membered carbo‐ and heterocycles bearing a trans‐configured double bond is described.
ChemInform Abstract: Zinc‐Catalyzed Dual C—X and C—H Borylation of Aryl Halides.
Authors: Bose Shubhankar Kumar , Deissenberger Andrea , Eichhorn Antonius , Steel Patrick G. , Lin Zhenyang , Marder Todd B. 
Published: January 2016

AbstractA combined C—halogen and ortho C—H borylation process is developed using aryl iodides and bromides and (Bpin)2 as the boron source.
Broadly Neutralizing Antibody‐Guided Carbohydrate‐Based HIV Vaccine Design: Challenges and Opportunities
Authors: Liu Chang‐Cheng , Zheng Xiu‐Jing , Ye Xin‐Shan 
Published: January 2016

AbstractThe HIV envelope (Env) is heavily glycosylated, facilitating the spread and survival of HIV in many ways. Some potent broadly neutralizing antibodies (bnAbs) such as 2G12, PG9, PG16, and PGTs can recognize the conserved glycan residues on Env. The bnAbs, which often emerge after many years of chronic infection, provide insight into the vulnerability of HIV and can therefore guide the design of vaccines. Many carbohydrate‐conjugated vaccines have been designed to induce bnAb‐like antibodies, but none have yet been successful. The low antigenicity of these vaccines is one possible explanation. New strategies have been applied to obtain high‐affinity antigens of glycan‐dependent and other bnAbs. However, when used as immunogens in vivo, high‐affinity antigens are still insufficient in eliciting bnAb‐like antibodies. bnAbs generally possess some unusual features and may therefore be suppressed by the host immune system. In view of this situation, some immunization regimens based on the affinity maturation of antibodies have been tested. Herein we summarize recent studies into the design of carbohydrate‐based HIV vaccines and some valuable experiences gained in work with other bnAb‐based HIV vaccines.
Effects of color on expectations of drug effects: A cross‐gender cross‐cultural study
Authors: Tao Da , Wang Tieyan , Wang Tieshan 
Published: January 2016

AbstractTo study the role of color in expectations of drug effects, 80 Chinese participants (40 females and 40 males) were asked to classify each of seven single colored capsules and six differently colored two‐piece capsules into one of four classifications of drug effects. The results from the Chinese sample were also compared with that from four other cultural groups studied elsewhere. The Chi‐square test results showed that all seven single colored capsules yielded non‐chance distributions in classifications of drug effects, with six showing specific effects; and that five two‐colored capsules had non‐chance distributions, with four significantly associated with specific effects. Notable gender differences were observed in the expectations of drug effects. While the cross‐group comparison revealed consistent red‐stimulant and blue‐depressant associations across the five cultural groups, disagreements existed for other colors among the groups. The findings emphasized the importance of color in drug design and administration in support of drug differentiation, medication adherence, and drug efficacy, and suggest gender and cultural implications on the basis of color to achieve better drug effects. © 2016 Wiley Periodicals, Inc. Col Res Appl, 42, 124–130, 2017
Palladium on Nitrogen‐Doped Mesoporous Carbon: A Bifunctional Catalyst for Formate‐Based, Carbon‐Neutral Hydrogen Storage
Authors: Wang Fanan , Xu Jinming , Shao Xianzhao , Su Xiong , Huang Yanqiang , Zhang Tao 
Published: January 2016

AbstractThe lack of safe, efficient, and economical hydrogen storage technologies is a hindrance to the realization of the hydrogen economy. Reported herein is a reversible formate‐based carbon‐neutral hydrogen storage system that is established over a novel catalyst comprising palladium nanoparticles supported on nitrogen‐doped mesoporous carbon. The support was fabricated by a hard template method and nitridated under a flow of ammonia. Detailed analyses demonstrate that this bicarbonate/formate redox equilibrium is promoted by the cooperative role of the doped nitrogen functionalities and the well‐dispersed, electron‐enriched palladium nanoparticles.
Dietary CLA supplementation of pigs confers higher oxidative stability to Ciauscolo and Fabriano salami produced from their meat with no negative impact on the physico‐chemical, microbiological and sensorial characteristics
Authors: Branciari Raffaella , Balzano Michele , Pacetti Deborah , Trabalza‐Marinucci Massimo , Della Casa Giacinto , Miraglia Dino , Capotorti Andrea , Frega Natale G. , Ranucci David 
Published: January 2016

It has been reported that conjugated linoleic acid (CLA) isomers are considered particularly beneficial to human health and affect the technological properties of pork meat products such as salami. The objective of this study was to evaluate the effect of 0.5% CLA supplementation of heavy pig diets on the chemical composition, total fatty acids (FA), oxidative stability, sensory and microbial properties of Ciauscolo and Fabriano salami. The incorporation of CLA into the diet did not modify the chemical, microbial or sensory descriptive analysis of the salami. The CLA dietary supplementation changed the proportions of FA, in particular leading to an increase in the proportion of saturated fatty acids and CLA in both Ciauscolo and Fabriano salami. The results of consumer testing showed a higher degree of liking by consumers when the CLA sample was accompanied by product information, demonstrating the strong influence of the label on consumer perception. The interesting finding was the increase in the oxidative stability of the salami at the end of ripening. This confirms the hypothesis that CLA can affect the saturated and monounsaturated fatty acids/monounsaturated FA ratio in meat products and possesses antioxidative properties that can be transferred, through dietary supplementation, to salami.Practical applications: Feeding a 0.5% CLA diet to finisher pigs resulted in changes in the proportions of FA and enhanced the oxidative stability of salami but did not modify the sensory properties of the products. More research is needed to find the right inclusion level of CLA to be considered optimal from the point of view of producing a high quality product with superior organoleptical, technological and potential health‐related properties.Production of value‐added meat products, such as conjugated linoleic acids (CLA) enriched Ciauscolo and Fabriano salamis, by the inclusion of the c9 t11 and t10 c12 CLA isomers in the swine diet.
Social environment alters opioid‐induced hyperalgesia and antinociceptive tolerance in adolescent mice
Authors: Bates M.L.S. , Emery M.A. , Wellman P.J. , Eitan S. 
Published: January 2016

AbstractBackgroundChronic opioid treatment is complicated by the development of tolerance and hyperalgesia. Social environment alters both opioid‐induced behaviours and nociceptive mechanisms. Our previous studies demonstrated that, in adolescent rodents, the susceptibility to acquire opioid dependence and reward is dependent on the nature of social housing conditions. Specifically, our previous studies demonstrate that housing morphine‐treated mice with drug‐naïve animals mitigates the abuse liability of opioids. Thus, this study tested the effect of social housing conditions on the development of adaptive processes to morphine antinociception.MethodAdolescent males were group‐housed in different conditions. In the mixed treatment condition, mice treated with 20 mg/kg morphine (i.e. ‘morphine cage‐mates’) and saline (i.e. ‘saline cage‐mates’) were housed together. In the separated treatment conditions, all mice in the cage received morphine (i.e. ‘morphine only’) or saline (i.e. ‘saline only’). All animals were tested for baseline pain sensitivity and for the response to morphine in the tail withdrawal, hot plate, acetone and von Frey filament tests, during and after discontinuation of opioid treatment.ResultsBoth morphine cage‐mate and morphine only animals developed antinociceptive tolerance. However, this effect was more robust and persistent in the morphine only group. Notably, morphine only animals, but not morphine cage‐mates, developed opioid‐induced hyperalgesia.ConclusionThis study demonstrates that housing morphine‐treated mice with drug‐naïve animals mitigates the development of opioid‐induced hyperalgesia and antinociceptive tolerance. Thus, this study indicates that social environment influences the effectiveness of opioid pain management.