bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polarimetric Radar Metrics Related to Tornado Life Cycles and Intensity in Supercell Storms
Authors: Van Den Broeke Matthew S. 
Published: June 2017

AbstractPolarimetric radar signatures have been related to the typical evolution of supercell storms, including through tornado life cycles. Now that polarimetric radar observations are available for a large sample of supercell storms, time series of new radar metrics can be derived. These metrics can be compared with phases of known tornado life cycles in an effort to develop new methods of anticipating tornadoes and to increase understanding of storm-scale structural and microphysical changes through supercell and tornado life cycles. In this paper, radar metrics including measures of differential reflectivity ZDR columns, ZDR arcs, polarimetrically inferred hailfall regions, and mean value of copolar correlation coefficient ρhv in the echo appendage are compared to the tornado life cycle and to storm-maximum tornado intensity in a sample of 35 tornadic supercells. It is shown that these radar metrics may change repeatedly and thus can be used to distinguish tornadic and nontornadic periods in single supercell storms, tornadogenesis from tornado demise times, and modes of storm evolution relative to tornadoes (e.g., if a storm produces one tornado or several). The polarimetric radar metrics are nearly as predictive of tornado intensity as commonly used measures of environmental variability for this sample.
Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta
Authors: Amudong Aierken , Muheremu Aikeremujiang , Abudourexiti Tuerhongjiang 
Published: June 2017

Objective To explore the relationship between cellular apoptosis and hypertrophy of the ligamentum flavum in the lumbar region. Methods Thirty patients with lumbar spinal stenosis were evaluated. Hypertrophy of the ligamentum flavum was present in 15 patients and absent in 15. Hematoxylin–eosin staining and transforming growth factor beta (TGF-β) immunohistochemical testing were applied to compare these two groups. Results Derangement of fibrous alignment, fibrocartilage changes, and infiltration of inflammatory cells were observed in the patients with hypertrophy of the ligamentum flavum, while fibrous alignment was normal and few inflammatory cells were observed in patients without hypertrophy. Immunohistochemical studies showed positive expression of TGF-β in patients with hypertrophy, while expression was negative in patients without hypertrophy. The integrated optical density was 2.6556708 in the hypertrophy group and 23104671 in the normal controls. Conclusions Expression of TGF-β was closely related to hypertrophy of the ligamentum flavum. Appropriate application of the TGF-β expression level can be used to predict progression of hypertrophy of the ligamentum flavum.
Known and unknown cerebral arteriovenous malformations in pregnancies: haemorrhage risk and influence on obstetric management
Authors: Lv Xianli , Li Wei , He Hongwei , Jiang Chuhan , Li Youxiang 
Published: June 2017

Objective The objective of this study was to evaluate the haemorrhage risk of known and unknown cerebral arteriovenous malformations and their obstetric management. Methods A retrospective review was performed and analysed 67 consecutive cases of arteriovenous malformation with pregnancy history. Results Sixty-seven cases of arteriovenous malformation with pregnancy histories were identified. In 14 cases (20.9%) of arteriovenous malformation diagnosed before pregnancy, 11 cases were treated (10 embolisation and one surgery), there was no haemorrhage in 14 pregnancies, 14 healthy babies were delivered by caesarean section in 12 pregnancies (85.7%) and vaginal delivery in two pregnancies (14.3%). In 53 cases (89.1%) of arteriovenous malformation diagnosed during/after pregnancy, there was one (1.6%) case of subarachnoid haemorrhage at 38 weeks’ gestation in 64 pregnancies, 64 healthy babies were delivered by caesarean section in 11 pregnancies (17.2%) and vaginal delivery in 53 pregnancies (82.8%). This resulted in 1.6% (95% confidence interval 0–4.6%) haemorrhage rate per pregnancy in unknown arteriovenous malformations. Known arteriovenous malformation gravida was prone to caesarean section; however, vaginal delivery did not increase the haemorrhage risk in unknown arteriovenous malformation gravidas (1.8% vs. 0%, P = 1.000). Conclusion Prior treatment for ruptured arteriovenous malformation could prevent its haemorrhage during pregnancy and the haemorrhage risk of unruptured arteriovenous malformation in pregnancies is low. Although known arteriovenous malformation gravida is prone to caesarean section, vaginal delivery seems not to increase the haemorrhage risk in unknown arteriovenous malformation gravidas.
Extended-release methylphenidate monotherapy in patients with comorbid social anxiety disorder and adult attention-deficit/hyperactivity disorder: retrospective case series
Authors: Koyuncu Ahmet , Çelebi Fahri , Ertekin Erhan , Kök Burcu Ece , Tükel Raşit 
Published: June 2017

Background: The relationship between social anxiety disorder (SAD) and attention-deficit/hyperactivity disorder (ADHD) is a subject which has recently become a topic of interest for research. Methods: In this study, 20 patients with comorbid SAD and adult ADHD who were treated with extended-release methylphenidate monotherapy were evaluated retrospectively. Results: Clinical response for both ADHD and SAD symptoms was observed in 17 of 20 patients. Overall, one patient did not respond to treatment and two patients dropped out of treatment at the beginning due to adverse effects. Conclusion: Extended-release methylphenidate improved both SAD and ADHD symptoms and was generally well tolerated. Further studies are required to investigate the relationship between SAD and ADHD.
Syk inhibitors interfere with erythrocyte membrane modification during P falciparum growth and suppress parasite egress
Authors: Pantaleo Antonella , Kesely Kristina R. , Pau Maria Carmina , Tsamesidis Ioannis , Schwarzer Evelin , Skorokhod Oleksii A. , Chien Huynh D. , Ponzi Marta , Bertuccini Lucia , Low Philip S. , Turrini Francesco M. 
Published: June 2017

Key PointsInhibitors of human Syk kinase suppress parasite egress. Syk inhibitors prevent the tyrosine phosphorylation of band 3 in P falciparum parasitized red blood cells, reducing the release of microparticles.
Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding
Authors: Westbury Sarah K. , Canault Matthias , Greene Daniel , Bermejo Emilse , Hanlon Katharine , Lambert Michele P. , Millar Carolyn M. , Nurden Paquita , Obaji Samya G. , Revel-Vilk Shoshana , Van Geet Chris , Downes Kate , Papadia Sofia , Tuna Salih , Watt Christopher ,   NIHR BioResource–Rare Diseases Consortium, Freson Kathleen , Laffan Michael A. , Ouwehand Willem H. , Alessi Marie-Christine , Turro Ernest , Mumford Andrew D. 
Published: June 2017

Key Points
Eleven pedigrees were identified with biallelic pathogenic variants in RASGPR2, which encodes platelet CalDAG-GEFI. CalDAG-GEFI deficiency is a severe, recessive, nonsyndromic platelet function disorder with defective aggregation to multiple agonists.
A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies
Authors: Liu Shu-Hui , Gu Yin , Pascual Bernadette , Yan Zhengming , Hallin Max , Zhang Cathy , Fan Conglin , Wang Wenlian , Lam Justine , Spilker Mary E. , Yafawi Rolla , Blasi Eileen , Simmons Brett , Huser Nanni , Ho Wei-Hsien , Lindquist Kevin , Tran Thomas-Toan , Kudaravalli Jyothirmayee , Ma Jing-Tyan , Jimenez Gretchen , Barman Ishita , Brown Colleen , Chin Sherman Michael , Costa Maria J. , Shelton David , Smeal Tod , Fantin Valeria R. , Pernasetti Flavia 
Published: June 2017

Key Points
PF-06747143, a novel CXCR4 antagonist IgG1 Ab, mobilizes malignant cells from the BM and induces their death via Fc-effector function. PF-06747143 reduces tumor burden in NHL, AML, and MM models, both as a monotherapy or in combination with standard-of-care agents.
Antagonizing miR-455-3p inhibits chemoresistance and aggressiveness in esophageal squamous cell carcinoma
Authors: Liu Aibin , Zhu Jinrong , Wu Geyan , Cao Lixue , Tan Zhanyao , Zhang Shuxia , Jiang Lili , Wu Jueheng , Li Mengfeng , Song Libing , Li Jun 
Published: June 2017

Abstract
Background
The plasticity of cancer stem cells (CSCs)/tumor-initiating cells (T-ICs) suggests that multiple CSC/T-IC subpopulations exist within a tumor and that multiple oncogenic pathways collaborate to maintain the CSC/T-IC state. Here, we aimed to identify potential therapeutic targets that concomitantly regulate multiple T-IC subpopulations and CSC/T-IC-associated pathways.

Methods
A chemoresistant patient-derived xenograft (PDX) model of human esophageal squamous cell carcinoma (ESCC) was employed to identify microRNAs that contribute to ESCC aggressiveness. The oncogenic effects of microRNA-455-3p (miR-455-3p) on ESCC chemoresistance and tumorigenesis were examined by in vivo and in vitro chemoresistance, tumorsphere formation, side-population, and in vivo limiting dilution assays. The roles of miR-455-3p in activation of the Wnt/β-catenin and transforming growth factor-β (TGF-β)/Smad pathways were determined by luciferase and RNA immunoprecipitation assays.

Results
We found that miR-455-3p played essential roles in ESCC chemoresistance and tumorigenesis. Treatment with a miR-455-3p antagomir dramatically chemosensitized ESCC cells and reduced the subpopulations of CD90+ and CD271+ T-ICs via deactivation of multiple stemness-associated pathways, including Wnt/β-catenin and TGF-β signaling. Importantly, miR-455-3p exhibited aberrant upregulation in various human cancer types, and was significantly associated with decreased overall survival of cancer patients.

Conclusions
Our results demonstrate that miR-455-3p functions as an oncomiR in ESCC progression and may provide a potential therapeutic target to achieve better clinical outcomes in cancer patients.
A Standardized Approach for Transfusion Medicine Support in Patients With Morbidly Adherent Placenta
Authors: Panigrahi Anil K. , Yeaton-Massey Amanda , Bakhtary Sara , Andrews Jennifer , Lyell Deirdre J. , Butwick Alexander J. , Goodnough Lawrence Tim 
Published: June 2017

BACKGROUND:
The incidence of placenta accreta (PA) has increased from 0.8 to 3.0 in 1000 pregnancies, driven by increased rates of cesarean deliveries (32.2% in 2014) of births in the United States. The average blood loss for a delivery complicated by PA ranges from 2000 to 5000 mL, frequently requiring substantial transfusion medicine support. We report our own institutional multidisciplinary approach for managing such patients, along with transfusion medicine outcomes, in this setting over a 5-year period.

METHODS:
We reviewed records for patients referred to our program in placental disorders from July 1, 2009, to July 1, 2014. A placental disorders preoperative checklist was implemented to ensure optimal management of patients with peripartum hemorrhage.

RESULTS:
Of 136 patients whose placentas were reviewed postpartum, 21 had PA, 39 had microscopic PA, 17 had increta, 17 had percreta, and 42 had no accreta (of which 11 had placenta previa). For each subtype, the percentage of patients receiving blood products were 71% (PA), 28% (microscopic PA), 82% (increta), 82% (percreta), and 19% (no accreta). Among patients with PA or variants, 89% of patients with PA or variants underwent postpartum hysterectomy, compared to only 5% of patients with no or microscopic PA.

CONCLUSIONS:
Based on our experience and on the findings of our retrospective analysis, patients presenting with either antepartum radiological evidence or clinical suspicion of morbidly adherent placenta will benefit from a standardized protocol for clinical management, including transfusion medicine support. We found that massive hemorrhage is predictable when abnormal placentation is identified predelivery and that blood product support is substantial regardless of the degree of placental invasiveness. The protocol at our institution provides immediate access to sufficient volumes and types of blood products at delivery for patients at highest risk for life-threatening obstetric hemorrhage. Therefore, for patients with a diagnosis of morbidly adherent placenta scheduled for planned cesarean delivery with possible hysterectomy, a programmatic checklist that mobilizes a multidisciplinary team, including proactive transfusion medicine support, represents best practices.
Nonlinear diffusion in transparent media: The resolvent equation
Authors: Giacomelli Lorenzo , Moll Salvador , Petitta Francesco 
Published: June 2017

AbstractWe consider the partial differential equationu-f=div⁡(um⁢∇⁡u|∇⁡u|)u-f=\operatornamewithlimits{div}\biggl{(}u^{m}\frac{\nabla u}{|\nabla u|}% \biggr{)}withfnonnegative and bounded andm∈ℝ{m\in\mathbb{R}}. We prove existence and uniqueness of solutions for both the Dirichlet problem (with bounded and nonnegative boundary datum) and the homogeneous Neumann problem. Solutions, which a priori belong to a space of truncated bounded variation functions, are shown to have zero jump part with respect to theℋN-1{{\mathcal{H}}^{N-1}}-Hausdorff measure. Results and proofs extend to more general nonlinearities.
Considerations for Selecting Field-Based Strength and Power Fitness Tests to Measure Asymmetries
Authors: Bishop Chris , Turner Anthony , Jarvis Paul , Chavda Shyam , Read Paul 
Published: June 2017

Abstract
Bishop, C, Turner, A, Jarvis, P, Chavda, S, and Read, P. Considerations for selecting field-based strength and power fitness tests to measure asymmetries. J Strength Cond Res 31(9): 2635–2644, 2017—The prevalence of lower limb asymmetries has been reported in numerous studies; however, methodological differences exist in the way they can be detected. Strength and jumping-based tasks have been most commonly used to examine these differences across both athlete and nonathlete populations. The aim of this review was to critically analyze the utility of strength and jumping tests that are frequently used to measure asymmetry. Reliability, validity, and considerations for assessment are examined to enhance test accuracy and effectiveness in the quantification of asymmetries during strength and jumping-based tasks. MEDLINE and SPORTDiscus databases were used with specific search terms to identify relevant articles in both athlete and nonathlete populations. The findings of the current review indicate that assessing interlimb differences during strength and jumping-based tasks may result in different levels of asymmetry; thus, interlimb differences seem to be task-dependent. Consequently, quantification during both types of assessment is warranted, and a selection of tests has been suggested to measure asymmetries in both strength and jumping-based tasks.
Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
Authors: Freedman Joshua D , Hagel Joachim , Scott Eleanor M , Psallidas Ioannis , Gupta Avinash , Spiers Laura , Miller Paul , Kanellakis Nikolaos , Ashfield Rebecca , Fisher Kerry D , Duffy Margaret R , Seymour Leonard W 
Published: June 2017

AbstractOncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express a bispecific single‐chain antibody, secreted from infected tumour cells into the microenvironment. This bispecific T‐cell engager (BiTE) binds to EpCAM on target cells and cross‐links them to CD3 on T cells, leading to clustering and activation of both CD4 and CD8 T cells. BiTE transcription can be controlled by the virus major late promoter, limiting expression to cancer cells that are permissive for virus replication. This approach can potentiate the cytotoxicity of EnAd, and we demonstrate using primary pleural effusions and peritoneal malignant ascites that infection of cancer cells with the BiTE‐expressing EnAd leads to activation of endogenous T cells to kill endogenous tumour cells despite the immunosuppressive environment. In this way, we have armed EnAd to combine both direct oncolysis and T cell‐mediated killing, yielding a potent therapeutic that should be readily transferred into the clinic.
Taxa de elocução e taxa de articulação em corpus utilizado na perícia de Comparação de Locutores
Authors: Gonçalves Cintia Schivinscki 
Published: June 2017

Neste estudo verificou-se a taxa de elocução (TE) e de articulação (TA), bem como a adequação do uso dessas medidas temporais na perícia de Comparação de Locutores. Calculou-se a TE/TA global e local média nas amostras de fala espontânea questionada (interceptações telefônicas judicialmente autorizadas realizadas sem a ciência dos locutores) e padrão (entrevista semidirigida gravada com o consentimento dos locutores) de sete falantes nativos do português brasileiro, de ambos os sexos, com idades entre 14 e 33 anos. Definiu-se o potencial individualizante da TE/TA e a relação entre essas e as variáveis independentes idade, sexo, escolaridade, tempo transcorrido entre as amostras (gap temporal), tipo de gravação e tamanho do intervalo de fala. Como resultado obteve-se coeficiente de correlação intraclasse satisfatório associado à TA, diferença significativa quanto à ciência da gravação na TE e correlação significativa entre gap temporal e TA e entre tamanho do intervalo de fala e TE.********************************************************************Speech rate and articulation rate in corpus used in the forensic Speaker ComparisonAbstract: This study examined the speech rate (SR) and the articulation rate (AR), as well as the appropriateness of the use of these temporal measures in the forensic Speaker Comparison. The global and local mean SR/AR in spontaneous speech samples – obtained from unaware audio recordings (legally authorized telephone interceptions) and known ones (semistructured interview) – from seven native speakers of Brazilian Portuguese, of both sexes, aged between 14 and 33 years were considered. The speaker-discriminating power of SR and AR and the relationship between rates and the independent variables age, sex, formal education, temporal gap between the recordings, type of recording, length of speech stretch were defined. As a result we obtained satisfactory intraclass correlation coefficient for the AR, significant difference between the factors of the variable type of recording in SR and significant correlation between temporal gap and AR and between length of speech stretch and SR.Keywords: Speech rate; Articulation rate; Forensic phonetics; Speaker Comparison
СТАЛИЙ РОЗВИТОК АГРОПРОДОВОЛЬЧОЇ СФЕРИ РЕГІОНУ НА ОСНОВІ КЛАСТЕРНОГО ПІДХОДУ
Authors: Самофатова В. А. 
Published: June 2017

В статті визначено сутність і передумови формування кластерів. Здійснено аналіз концептуальних підходів до формування і розвитку кластерів. Зосереджено увагу на доцільності створення і функціонування кластерів у агропродовольчій сфері Південного регіону. Проаналізовано потенціал розвитку агропродовольчої сфери Південного регіону за допомогою SWOT-аналізу як інструменту стратегічного управління
ІНТЕГРАЦІЙНІ ТЕНДЕНЦІЇ ТА ПРОБЛЕМИ РОЗВИТКУ УКРАЇНСЬКОГО РИНКУ МАКАРОННИХ ВИРОБІВ
Authors: Нікішина О. В. 
Published: June 2017

Здійснено аналіз динаміки відтворювальних процесів у секторах вітчизняного ринку макаронних виробів, визначено вектори сучасних інтеграційних процесів у системі вертикально суміжних до макаронного ринку, ідентифіковано прояви латентної дезінтеграції в міжринкових товарно-фінансових взаємодіях у межах даної системи. Систематизовано головні економічні проблеми розвитку виробничого сектору релевантного ринку, визначено трансформаційний вплив державного цінового регулювання на доходність підприємств. Обґрунтовано напрями побудови керованого інтеграційного механізму міжсуб’єктних взаємодій з цільовою орієнтацією на збалансований розвиток системи вертикально суміжних до макаронного ринків.
КОНКУРЕНТОСПРОМОЖНІСТЬ: СУТНІСТЬ ТА ОБ’ЄКТИ ДОСЛІДЖЕННЯ
Authors: Баранюк Х. О. 
Published: June 2017

В статті було розглянуто сутність категорії «конкурентоспроможність», яка представлена в публікаціях вітчизняних та іноземних вчених, об’єктів та рівнів дослідження, при дослідженні зроблено акцент саме на «конкурентоспроможність підприємства». Підкреслено, що ефективність економіки України не можлива без ефективного функціонування вітчизняних підприємств харчової промисловості, в тому числі підприємств малого бізнесу, що потребує забезпечення їх конкурентоспроможності, захисту і підтримки з боку держави. Удосконалено визначення сутності категорії «конкурентоспроможність підприємства малого бізнесу».
ХАРАКТЕРИСТИКА ПОЛБИ ЯК ПЕРСПЕКТИВНОЇ ЗЕРНОВОЇ КУЛЬТУРИ ТА ОСНОВНІ ПРОБЛЕМИ ЇЇ ПІСЛЯ ЗБИРАЛЬНОГО ОБРОБЛЕННЯ
Authors: ВАСИЛЬЄВ С. В. 
Published: June 2017

У статті здійснено огляд наукових праць, спрямованих на вивчення біологічних, фізико-технологічних і хімікотехнологічних властивостей зерна полби та визначення можливостей застосування продуктів його перероблення як сировини в харчовому виробництві. Показано, що сучасні сорти полби, зокрема й української селекції, створені з використанням генетичного потенціалу видів-співродичів, відзначаються, порівняно зі звичайною пшеницею, підвищеним вмістом білка, харчових волокон, незамінних мікроелементів (заліза, цинку, магнію), вітамінів групи В, вищою біологічною повноцінністю за амінокислотним складом, що суттєво збільшує поживну цінність страв і виробів із зерна цього злаку та дає змогу значно розширити асортимент продукції оздоровчого призначення. Розглянуто чинники, які актуалізують перспективність використання зерна полби як сировини у борошномельнокруп’яній, хлібопекарській і кондитерській галузях харчової промисловості, а також окреслено основні науково-практичні проблеми, що виникають на стадії його післязбирального оброблення й потребують ретельного вивчення та розв’язання. Сформульовано й обґрунтовано вихідні методологічні положення, які буде покладено в основу власних наукових досліджень у цьому напрямі. Акцентовано увагу на результатах проведених науковцями досліджень, які підтверджують доцільність і перспективність використання полб’яного борошна в рецептурах приготування хлібобулочних і кондитерських виробів. Запропоновані технології передбачають використання його як поліпшувача, а також для виробництва з нього харчових продуктів у чистому вигляді. За одностайним визнанням авторів праць, полба є безцінною круп’яною культурою, з якої в багатьох країнах готують страви високої смакової та поживної якості. На підставі аналізу численних напрацювань вітчизняних і зарубіжних учених зроблено також висновок про особливу цінність полб’яної пшениці за біологічними властивостями, зокрема скоростиглістю, невибагливістю до ґрунтовокліматичних умов вирощування, підвищеною стійкістю до шкідників та хвороб, що свідчить про актуальність відродження цієї зернової культури та збільшення її посівних площ в Україні в сучасних умовах.