bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limitations of ocular care facility use amongst fifty period aged as well as greater population inside western Afghanistan. A descriptive research
Authors: Rahimi Ghulam Farooq , Rahimi Ibrarullah , Zahirzai Mohammad Sediqe , Sherzad Abdul Ghafar 
Published: September 2024

Background: Visual impairment and blindness from ocular diseases are important public health difficulty in developing countries, including Afghanistan. Evidence recommends that poor uptake of available eye services by potential beneficiaries is a major barrier for achieving a global reception to eye services. This research was performed to observe the limitation to use ocular care facilities between people elderly 50 life-span and greater inside Eye Department of Nangarhar University Teaching Hospital, Nangarhar-Afghanistan. Materials & Methods: The information of this descriptive research was accumulated 794 recently recorded patients who came for receiving ocular care facilities during 1-June-2020 to 20 December- 2020. Information was analyzed with IBM SPSS (version 21). Descriptive statistics of the variables were tabulated in frequency chart with percentile, bivariate analysis of the variables were carried out utilizing chi-square tests, p-value less than 0.05 considered as notable. Findings: Inside the Out Patient Department (OPD), from 800 recently recorded patients, 794 approve (99.3%) and finished meeting following ocular investigation. The ordinary limits to ocular health facility use were reported at the moment that ‘issue un sensed’ by 77,3%., accompanied by ‘un cash to move’ 12,0%, as well as ‘no one to help’ 11.2%, ‘this is extremely away’ 2.6%, ‘ this is from Allah,s view’ 0.9%, ‘ no moment for turning to ’ 0.8%, as well as ‘unable move (according of the other illnesses) 0.6% properly . Conclusion: Major part of the participants have never used the ocular care facilities due to an alert of the issues. In fact, a few preventable deprive of sight ocular illnesses which are persistent in genius and progress extremely unhurriedly without recognizing the issue inside the ocular, leading to absolute vision loss prior to searching for care, for the reason subordinate avoidable measures and society based ocular keeping safe advancement timetable including ocular keeping safe instruction inside the society are approved. Health advancement stages compulsory to incorporate community based health education as well as to observe the ways of making ocular care facilities inexpensive inside rustic area.
Numerical implementation of solving a boundary value problem with parameter for Fredholm integro-differential equation
Authors: Bakirova Elmira , Iskakova Narkesh , Kadirbayeva Zhazira 
Published: September 2024

The boundary value problem with parameter for Fredholm integro-differential equation with degenerate kernel is investigated in this paper. The aim of the paper is to establish the solvability conditions, to construct analytical and numerical solutions of the considered problem. The basis for achieving the goal is the ideas of Dzhumabayev parameterization method, classical numerical methods of solving Cauchy problems and numerical integration techniques. A problem with parameters is obtained by introducing an additional parameter and a new unknown function. A system of equations with respect to parameters is compiled according to the initial data of the considered equation and boundary conditions. The unknown function is found as a solution of the Cauchy problem for the ordinary differential equation. The equivalence of the original problem and the problem with parameters, the conditions of unique solvability are established and the formula for finding an analytical solution is obtained. Test examples of finding analytical and approximate solutions of the original problem are given.
Kilka uwag o odpowiedzialności karnej za nakłanianie lub udzielenie pomocy w przerwaniu ciąży za zgodą kobiety i o aborcji ze wskazań terapeutycznych.
Authors: Plebanek Ewa 
Published: September 2024

This paper focuses on selected Issues of the criminal liability for the participation in the abortion on the basis of provisions being in force. Analysis concerns the possibility of punishing for the incitement and the assistance to terminate pregnancy. The following paper examines the criteria of the act prohibited under Article 152 of the Polish Criminal Code with the blanket clause referring to the Act on Family Planning after the Constitutional Tribunal’s Judgment of 22 October 2020, K 1/20 which judgment eliminated the embryopathological grounds for termination of pregnancy.
Czy podawanie leków aptecznych z innych państw Unii Europejskiej stanowi przestępstwo wprowadzania do obrotu produktów leczniczych bez pozwolenia? Rozważania na tle art. 124 Prawa farmaceutycznego
Authors: Bobkier Robert 
Published: September 2024

Art. 124 of the Pharmaceutical Law penalizes the act of placing a medicinal product on the market without a marketing authorization. On the basis of this provision, consideration should be given to the worrying practice of instituting criminal proceedings by law enforcement agencies against doctors, who administer to patients, pharmaceutical drugs manufactured in other EU countries, than Poland. The subject of the first part of the article is to answer the question whether the administration of medicinal products to patients, as part of the conducted medical practice, constitutes an act of placing on the market at all. For this purpose, the notion of medical services and treatment in terms of Polish law, doctrine and Community regulations was analyzed. Subsequently, the subject of considerations is the characteristic of "placing on the market" under Art. 124 of the Pharmaceutical Law, not defined in this Act. Against the background of the judicial activity of the Supreme Court and common courts, an clearly view can be formulated, that the perpetrator of the act may only be the person who made the first transaction with a medicinal product, transferring its possession for further circulation by physically handing it over to the recipient. This position is also confirmed by other penal provisions of the Pharmaceutical Law, which use additional features of "use" and "sharing" of a medicinal product. Thus, it should be considered that in Art. 124 of the Pharmaceutical Law, the legislator decided to criminalize only the act of placing medicinal products on the market, without providing for a criminal sanction for their use, delivery or making available.
Udoskonalanie człowieka. Uwagi na marginesie przypadku udoskonalonego lekarza
Authors: Holocher Justyna , Kosielińska-Grabowska Urszula 
Published: September 2024

The problem of human enhancement technologies (HET) is linked to Transhumanism, a trend which advocates the improvement of human beings and the possibility of taking control of ever larger areas of human activity. Using enhancers might appear desirable, but permitting (or perhaps making obligatory) the use of enhancers by certain professional groups raises important issues. Medical professionals in particular bear technical, moral and legal responsibilities for the lives and health of other people, and questions relating to the involvement of enhancers on the part of practitioners touch upon a number of concerns. Among them are agreement on the definition of 'enhancement and 'enhancers; the motivations for which a physician has decided to use HET, and not least, the consequences for safeguarding patient rights. These issues must be decided under the applicable standards and regimes of civil, criminal or professional liability. These regimes do not at present refer directly to the responsibility of an 'enhanced' physician. They propose, however a 'cautious' approach to the problems of the use of enhancers, indicating that use of technologies (that are not already specifically prohibited) might be permitted where there is no exposure to the possibility of harm or any threat to human life or health. The de lege ferenda proposal is to introduce legislative changes which would specifically and unequivocally refer to the situations under consideration.
Penser le développement des compétences transformatives par les arts dans une perspective d’interculturalité
Authors: Rosso Nithaël , Terrien Pascal 
Published: September 2024

Un individu se construit en interaction avec son environnement. La société française présente une pluriculturalité venant interroger notamment la transmission des normes et des valeurs à l’École. Cette dernière est investie d’une fonction sociale visant l’émancipation et la cohésion des personnes dans la société. Les politiques éducatives françaises tournées vers l’homogénéisation des traits culturels créent de débats vifs quant au partage d’un même espace-temps (Garnier, 2014). Par conséquent, le développement de compétences socio-citoyennes et interculturelles à travers les enseignements artistiques pourrait ainsi être pensé comme un outil favorisant l’unité sociale. Cet article pose quelques préalables conceptuels à l’axe « Le développement de compétences transformatives à travers l’apprentissage des et par les arts ». La méthodologie réside en une analyse comparative de différents textes institutionnels français afin d’étudier la pertinence des enseignements artistiques dans une perspective interculturelle (Abdallah-Pretceille, 1997).
Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients
Authors: Lötsch Jörn , Gasimli Khayal , Malkusch Sebastian , Hahnefeld Lisa , Angioni Carlo , Schreiber Yannick , Trautmann Sandra , Wedel Saskia , Thomas Dominique , Ferreiros Bouzas Nerea , Brandts Christian H , Schnappauf Benjamin , Solbach Christine , Geisslinger Gerd , Sisignano Marco 
Published: September 2024

Background:Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify the particular types of lipids that are regulated as a consequence of paclitaxel administration and may be associated with the occurrence of post-therapeutic neuropathy.Methods:High-resolution mass spectrometry lipidomics was applied to quantify d=255 different lipid mediators in the blood of n=31 patients drawn before and after paclitaxel therapy for breast cancer treatment. A variety of supervised statistical and machine-learning methods was applied to identify lipids that were regulated during paclitaxel therapy or differed among patients with and without post-therapeutic neuropathy.Results:Twenty-seven lipids were identified that carried relevant information to train machine learning algorithms to identify, in new cases, whether a blood sample was drawn before or after paclitaxel therapy with a median balanced accuracy of up to 90%. One of the top hits, sphinganine-1-phosphate (SA1P), was found to induce calcium transients in sensory neurons via the transient receptor potential vanilloid 1 (TRPV1) channel and sphingosine-1-phosphate receptors.SA1P also showed different blood concentrations between patients with and without neuropathy.Conclusions:Present findings suggest a role for sphinganine-1-phosphate in paclitaxel-induced biological changes associated with neuropathic side effects. The identified SA1P, through its receptors, may provide a potential drug target for co-therapy with paclitaxel to reduce one of its major and therapy-limiting side effects.Funding:This work was supported by the Deutsche Forschungsgemeinschaft (German Research Foundation, DFG, Grants SFB1039 A09 and Z01) and by the Fraunhofer Foundation Project: Neuropathic Pain as well as the Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD). This work was also supported by the Leistungszentrum Innovative Therapeutics (TheraNova) funded by the Fraunhofer Society and the Hessian Ministry of Science and Arts. Jörn Lötsch was supported by the Deutsche Forschungsgemeinschaft (DFG LO 612/16-1).
Gene expression panel predicts metastatic‐lethal prostate cancer outcomes in men diagnosed with clinically localized prostate cancer
Authors: Rubicz Rohina , Zhao Shanshan , Wright Jonathan L. , Coleman Ilsa , Grasso Catherine , Geybels Milan S. , Leonardson Amy , Kolb Suzanne , April Craig , Bibikova Marina , Troyer Dean , Lance Raymond , Lin Daniel W. , Ostrander Elaine A. , Nelson Peter S. , Fan Jian‐Bing , Feng Ziding , Stanford Janet L. 
Published: February 2017

Prognostic biomarkers are needed to distinguish patients with clinically localized prostate cancer (PCa) who are at high risk of metastatic progression. The tumor transcriptome may reveal its aggressiveness potential and have utility for predicting adverse patient outcomes. Genomewide gene expression levels were measured in primary tumor samples of 383 patients in a population‐based discovery cohort, and from an independent clinical validation dataset of 78 patients. Patients were followed for ≥ 5 years after radical prostatectomy to ascertain outcomes. Area under the receiver‐operating characteristic curve (AUC), partialAUC(pAUC, 95% specificity), andP‐value criteria were used to detect and validate the differentially expressed transcripts. Twenty‐three differentially expressed transcripts in patients with metastatic‐lethal compared with nonrecurrentPCa were validated (P < 0.05; false discovery rate < 0.20) in the independent dataset. The addition of each validated transcript to a model with Gleason score showed that 17 transcripts significantly improved theAUC(range: 0.83–0.88; allP‐values < 0.05). These differentially expressedmRNAs represent genes with diverse cellular functions related to tumor aggressiveness. This study validated 23 gene transcripts for predicting metastatic‐lethalPCa in patients surgically treated for clinically localized disease. Several of thesemRNAbiomarkers have clinical potential for identifying the subset of PCa patients with more aggressive tumors who would benefit from closer monitoring and adjuvant therapy.
Mechanical models favor a ramp geometry for the Ventura‐pitas point fault, California
Authors: Marshall Scott T. , Funning Gareth J. , Krueger Hannah E. , Owen Susan E. , Loveless John P. 
Published: February 2017

AbstractRecent investigations have provided new and significantly revised constraints on the subsurface structure of the Ventura‐Pitas Point fault system in southern California; however, few data directly constrain fault surfaces below ~6 km depth. Here, we use geometrically complex three‐dimensional mechanical models driven by current geodetic strain rates to test two proposed subsurface models of the fault system. We find that the model that incorporates a ramp geometry for the Ventura‐Pitas Point fault better reproduces both the regional long term geologic slip rate data and interseismic GPS observations of uplift in the Santa Ynez Mountains. The model‐calculated average reverse slip rate for the Ventura‐Pitas Point fault is 3.5 ± 0.3 mm/yr, although slip rates are spatially variable on the fault surface with > 8 mm/yr predicted on portions of the lower ramp section at depth.
N2‐Substituted 2′‐Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ
Authors: Gowda A. S. Prakasha , Lee Marietta , Spratt Thomas E. 
Published: February 2017

AbstractN2‐Alkyl‐2′‐deoxyguanosine triphosphate (N2‐alkyl‐dGTP) derivatives with methyl, butyl, benzyl, or 4‐ethynylbenzyl substituents were prepared and tested as substrates for human DNA polymerases. N2‐Benzyl‐dGTP was equal to dGTP as a substrate for DNA polymerase κ (pol κ), but was a poor substrate for pols β, δ, η, ι, or ν. In vivo reactivity was evaluated through incubation of N2‐4‐ethynylbenzyl‐dG with wild‐type and pol κ deficient mouse embryonic fibroblasts. CuAAC reaction with 5(6)‐FAM‐azide demonstrated that only cells containing pol κ were able to incorporate N2‐4‐ethynylbenzyl‐dG into the nucleus. This is the first instance of a Y‐family‐polymerase‐specific dNTP, and this method could be used to probe the activity of pol κ in vivo.
Transformation of Dipeptide‐Based Organogels into Chiral Crystals by Cryogenic Treatment
Authors: Liu Xingcen , Fei Jinbo , Wang Anhe , Cui Wei , Zhu Pengli , Li Junbai 
Published: February 2017

AbstractControlled molecular assembly is an important approach for the synthesis of single‐component materials with diverse functions. Unlike traditional heat treatment or solvent modulation, cryogenic treatment at 77 K enabled the tunable transition of a self‐assembled diphenylalanine organogel into a hexagonal crystal. Under these conditions, the assembled molecules undergo an internal rearrangement in the solid state to form a well‐defined chiral crystal structure. Moreover, these assemblies exhibit enhanced emission. This strategy for the synthesis of single‐component supramolecular assemblies can create new functions by manipulating phase transitions.
Optical Distinction between “Slow” and “Fast” Translational Motion in Degenerate Molecular Shuttles
Authors: Vukotic V. Nicholas , Zhu Kelong , Baggi Giorgio , Loeb Stephen J. 
Published: February 2017

AbstractA series of six [2]rotaxane molecular shuttles was designed which contain an axle with a benzo‐bis(imidazole) core (in either a neutral or dicationic form) and a single 24‐membered, crown ether wheel (24C6, B24C6, or DMB24C6), and the shuttling rates of the ring along the axle were determined. The charged versions showed much slower shuttling rates as a result of the increase in noncovalent interactions between the axle and wheel. The [2]rotaxane with a B24C6 wheel shows a difference in fluorescence between the charged and neutral species, while the [2]rotaxane with a DMB24C6 wheel exhibits a difference in color between the charged and neutral compounds. These changes in optical properties can be attributed to the structural differences in the co‐conformations of the [2]rotaxane as they adapt to the changes in acid/base chemistry. This allowed the relative rate of the translational motion of a molecular shuttle to be determined by observation of a simple optical probe.
A Stimuli‐Responsive Smart Lanthanide Nanocomposite for Multidimensional Optical Recording and Encryption
Authors: Li Xiang , Xie Yujie , Song Bo , Zhang Hao‐Li , Chen Hao , Cai Huijuan , Liu Weisheng , Tang Yu 
Published: February 2017

AbstractA stimuli‐responsive lanthanide‐based smart nanocomposite has been fabricated by supramolecular assembly and applied as an active material in multidimensional memory materials. Conjugation of the lanthanide complexes with carbon dots provides a stimuli response that is based on the modulation of the energy level of the ligand and affords microsecond‐to‐nanosecond fluorescence lifetimes, giving rise to intriguing memory performance in the spatial and temporal dimension. The present study points to a new direction for the future development of multidimensional memory materials based on inorganic–organic hybrid nanosystems.
Measuring Nanoscale Thermostability of Cell Membranes with Single Gold–Diamond Nanohybrids
Authors: Tsai Pei‐Chang , Epperla Chandra P. , Huang Jo‐Shan , Chen Oliver Y. , Wu Chih‐Che , Chang Huan‐Cheng 
Published: February 2017

AbstractMuch of the current understanding of thermal effects in biological systems is based on macroscopic measurements. There is little knowledge about the local thermostability or heat tolerance of subcellular components at the nanoscale. Herein, we show that gold nanorod–fluorescent nanodiamond (GNR‐FND) hybrids are useful as a combined nanoheater/nanothermometer in living cells. With the use of a 594 nm laser for both heating and probing, we measure the temperature changes by recording the spectral shifts of the zero‐phonon lines of negatively charged nitrogen‐vacancy centers in FNDs. The technique allows us to determine the rupture temperatures of individual membrane nanotubes in human embryonic kidney cells, as well as to generate high temperature gradients on the cell membrane for photoporation and optically controlled hyperthermia. Our results demonstrate a new paradigm for hyperthermia research and application.
Cycloparaphenylenes and Their Catenanes: Complex Macrocycles Unveiled by Ion Mobility Mass Spectrometry
Authors: Zhang Wen , Abdulkarim Ali , Golling Florian E. , Räder Hans Joachim , Müllen Klaus 
Published: February 2017

AbstractThe insoluble product mixture obtained from cycloparaphenylene (CPP) synthesis from Suzuki coupling and reductive aromatization was analyzed. Traditional mass spectrometry suggests a homologous series of macrocycles with 12 to 84 phenylene units. Ion‐mobility mass spectrometry, however, unravels an unexpected complexity of isomers with identical chemical formula, but different topologies. Whereas macrocycles containing up to 30 phenylene units show only one structure, the homologue with 36 phenylene units forms at least four different isomers with significant molecular size differences. They can be assigned to catenanes composed of CPPs with 2×18 and 12+24 phenylene units together with the ordinary [36]CPP macrocycle. Most likely, a trefoil knot of the CPP with 36 moieties is also present. For the first time, catenanes can be elucidated in a simple reaction mixture by analyzing their ions in the gas phase, an analysis which lies beyond the scope of traditional analytical methods.
Messtechnische Untersuchung der Trocknung und des mikrobiellen Wachstums nach irregulären Feuchtezuständen in Estrichdämmschichten
Authors: Gebauer Ralf , Bianchi‐Janetti Michele , Ochs Fabian , Feist Wolfgang , Kirchmair Martin 
Published: February 2017

AbstractDie Bodenaufbauten von beheizten Massivgebäuden werden fast ausschließlich als Estriche auf Dämmschichten ausgeführt. Diese schwimmenden Estriche sind überwiegend nicht abgedichtet. Tritt ungewollt Wasser in solchen Gebäuden aus, läuft dieses über die Estrich‐Randfugen und sonstige Öffnungen in die Dämmschichtebene unter dem Estrich. Stahlbeton‐Geschossdecken (und ‐Bodenplatten) sind meist so dicht, dass das eingedrungene Wasser zunächst zwischen der Geschossdecke und der Dämmschichtebene verbleibt. Ist genügend freie Feuchtigkeit auf den Bauteiloberflächen vorhanden, keimen und wachsen nach kurzer Zeit mikrobiologische Lebewesen. Um solches Wachstum zu beenden bzw. die Auskeimung zu verhindern und weitere negative Einflüsse der Feuchtigkeit auf Bauteile zu vermeiden, werden solche Estriche technisch getrocknet. Die Untersuchung zeigt, dass bei den am häufigsten verwendeten Materialkombinationen eine technische Trocknung von Estrichen auf Dämmschichten nicht sicher und vollständig erreicht wird. Eine mikrobielle Eskalation während der Trocknung ist unvermeidbar. Durch den Einbau einer Ventilationsschicht zwischen der Stahlbeton‐Geschossdecke oder ‐Bodenplatte konnte eine vollständige Trocknung der Dämmplatten erzielt werden. Eine mikrobielle Eskalation hat sich dabei nicht eingestellt.