bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Modification on Hoffman’s Pocket Technique With Scleral Fixation of Intraocular Lens (IOL), Case Series of Unique Scenarios
Authors: Alsirhy Ehab , Alanazi Tariq , Alghamdi Nawaf , Alorainy Jehad , Alanzan Abdullah , Alwadani Saeed 
Published: October 2024

Purpose: The purpose of this study is to present our experience with Hoffman’s SFIOL using double‐armed Gore‐Tex sutures (polytetrafluoroethylene) instead of 9.0 polypropylene suture method in four cases.Observation: In this case series article, we present our experience with Hoffman’s SFIOL using double‐armed Gore‐Tex sutures (polytetrafluoroethylene) instead of 9.0 polypropylene sutures; the postoperative evaluation revealed well‐centered IOL which did not exhibit any signs of instability in all four eyes, demonstrating a successful surgical outcome without observed complications.Conclusions and Importance: Hoffman’s SFIOL using double‐armed Gore‐Tex could be safe and effective methods for cases with no adequate capsular support for the IOL implantation. Compared to prolene suture, Gore‐Tex gives more tensile strength and requires less manipulation during surgery minimizing postoperative inflammation which could be a valuable option in the nearby future for similar cases.
A Rare Presentation of Intracerebellar Schwannoma: A Case Report
Authors: Alhantoobi Mohamed , Alkhoori Nadeen , Khayat Hassan , Zhang Euan , Algird Almunder , Provias John 
Published: October 2024

Background: Intracerebellar schwannoma is an extremely rare disease entity with only 21 case reports described in the literature.Case Description: A 68‐year‐old male presented with chronic headaches, dizziness, gait imbalance, and incoordination. Previous MRI had revealed a cystic lesion in the right cerebellum; however, patient was lost to follow‐up. Updated MRI revealed dramatic enlargement of the lesion in addition to worsening clinical status. The patient underwent successful surgical resection.Conclusion: Intracerebellar schwannoma can be challenging to diagnose preoperatively due to its rare occurrence; however, it should be included in the differential diagnosis of cystic lesions in the cerebellum, and most cases can be successfully treated with complete surgical resection. Pathological examination revealed a spindle cell neoplasm with other typical histopathological features of schwannoma.
KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition
Authors: Fey Sigrid K. , Najumudeen Arafath K. , Watt Dale M. , Millett Laura M. , Ford Catriona A. , Gilroy Kathryn , Simpson Rosalin J. , McLay Kathy , Upstill-Goddard Rosanna , Chang David , Clark William , Nixon Colin , Birch Joanna L. , Barry Simon T. , Morton Jennifer P. , Campbell Andrew D. , Sansom Owen J. 
Published: October 2024

Abstract
Pancreatic cancer is characterized by the prevalence of oncogenic mutations in KRAS. Previous studies have reported that altered KRAS gene dosage drives progression and metastasis in pancreatic cancer. Whereas the role of oncogenic KRAS mutations is well characterized, the relevance of the partnering wild-type (WT) KRAS allele in pancreatic cancer is less well understood and controversial. Using in vivo mouse modeling of pancreatic cancer, we demonstrated that WT KRAS restrains the oncogenic impact of mutant KRAS and dramatically impacts both KRAS-mediated tumorigenesis and therapeutic response. Mechanistically, deletion of WT Kras increased oncogenic KRAS signaling through the downstream MAPK effector pathway, driving pancreatic intraepithelial neoplasia initiation. In addition, in the KPC mouse model, a more aggressive model of pancreatic cancer, lack of WT KRAS led to accelerated initiation but delayed tumor progression. These tumors had altered stroma and an enrichment of immunogenic gene signatures. Importantly, loss of WT Kras sensitized Kras mutant tumors to MEK1/2 inhibition though tumors eventually became resistant and then rapidly progressed. This study demonstrates the repressive role of WT KRAS during pancreatic tumorigenesis and highlights the critical impact of the presence of WT KRAS in both tumor progression and therapeutic response in pancreatic cancer.
Significance: KRAS allelic status impacts pancreatic cancer progression and has the potential to guide effective treatment in a substantial subset of patients.
Large-Scale Comparative Analysis of Canine and Human Osteosarcomas Uncovers Conserved Clinically Relevant Tumor Microenvironment Subtypes
Authors: Patkar Sushant , Mannheimer Joshua , Harmon Stephanie A. , Ramirez Christina J. , Mazcko Christina N. , Choyke Peter L. , Brown Gregory Thomas , Turkbey Baris , LeBlanc Amy K. , Beck Jessica A. 
Published: October 2024

Abstract

Purpose:
Osteosarcoma is an aggressive bone cancer lacking robust biomarkers for personalized treatment. Despite its scarcity in humans, it is relatively common in adult pet dogs. This study aimed to analyze clinically annotated bulk tumor transcriptomic datasets of canine and patients with human osteosarcoma to identify potentially conserved patterns of disease progression.

Experimental Design:
Bulk transcriptomic data from 245 pet dogs with treatment-naïve appendicular osteosarcoma were analyzed using deconvolution to characterize the tumor microenvironment (TME). The TME of both primary and metastatic tumors derived from the same dog was compared, and its impact on canine survival was assessed. A machine learning model was developed to classify the TME based on its inferred composition using canine tumor data. This model was applied to eight independent human osteosarcoma datasets to assess its generalizability and prognostic value.

Results:
This study found three distinct TME subtypes of canine osteosarcoma based on cell type composition of bulk tumor samples: immune enriched, immune enriched dense extracellular matrix-like, and immune desert. These three TME-based subtypes of canine osteosarcomas were conserved in humans and could predict progression-free survival outcomes of human patients, independent of conventional prognostic factors such as percent tumor necrosis post standard of care chemotherapy treatment and disease stage at diagnosis.

Conclusions:
These findings demonstrate the potential of leveraging data from naturally occurring cancers in canines to model the complexity of the human osteosarcoma TME, offering a promising avenue for the discovery of novel biomarkers and developing more effective precision oncology treatments.
Processing, evaluating, and understanding FMRI data with afni_proc.py
Authors: Reynolds Richard C. , Glen Daniel R. , Chen Gang , Saad Ziad S. , Cox Robert W. , Taylor Paul A. 
Published: October 2024

Abstract
FMRI data are noisy, complicated to acquire, and typically go through many steps of processing before they are used in a study or clinical practice. Being able to visualize and understand the data from the start through the completion of processing, while being confident that each intermediate step was successful, is challenging. AFNI’s afni_proc.py is a tool to create and run a processing pipeline for FMRI data. With its flexible features, afni_proc.py allows users to both control and evaluate their processing at a detailed level. It has been designed to keep users informed about all processing steps: it does not just process the data, but also first outputs a fully commented processing script that the users can read, query, interpret, and refer back to. Having this full provenance is important for being able to understand each step of processing; it also promotes transparency and reproducibility by keeping the record of individual-level processing and modeling specifics in a single, shareable place. Additionally, afni_proc.py creates pipelines that contain several automatic self-checks for potential problems during runtime. The output directory contains a dictionary of relevant quantities that can be programmatically queried for potential issues and a systematic, interactive quality control (QC) HTML. All of these features help users evaluate and understand their data and processing in detail. We describe these and other aspects of afni_proc.py here using a set of task-based and resting-state FMRI example commands.
Proline: A versatile amino acid in the presence of salinity and drought in the Capsicum genus
Authors: Escalante-Magaña Camilo , Lizama-Gasca Marta , Bojorquez-Quintal Emanuel , Medina-Lara Maria de Fatima , Echevarria-Machado Ileana , Martínez-Estevez Manuel 
Published: October 2024

Abstract
Proline (Pro) is a low-molecular-weight cyclic amino acid that plays an important role as a source of energy and reducing power and as a source of carbon and nitrogen compounds for plant development. In most plant species, Pro is considered a stress marker. It is also a common compatible solute and is used cumulatively by plants under osmotic stress. The pepper genus, which includes species of great economic importance distributed throughout the world, is the target of different types of stresses, both biotic and abiotic, and Pro plays an important role in tolerance to some of these stresses. In this work, we discuss the general aspects of the metabolism, transport, and different functions of Pro in the Capsicum genus. Special focus is given to critical investigations that should be conducted with respect to Pro accumulation under stress conditions, such as salinity and water deficit.
Educational and Career Trajectories in Russia: Introducing a New Source and Datasets with a High Granularity
Authors: Valko Danila , Vasilevskaia Mariia , Bunina Maria , Kozlova Mariia , Filippova Anna Maria , Rud Daria 
Published: October 2024

Abstract
Studying Russian society is challenging, especially during the period of the Russian military invasion. However, it takes on special significance during a period of economic and social transformation. Studying the career and educational trajectories of Russians in the context of East Studies offers a multifaceted perspective on the state of the job market and education sector and gives an understanding of the current situation of the country’s economy and social structure. The lack of data with a high level of granularity is critical, especially for studying people with a focus on their career and educational trajectories. In this article, the authors respond to this request and present two datasets that can be useful for studying spatial and temporal patterns associated with people’s life trajectories in the context of work and education. The authors utilised open data on cv s created or updated by employment portal users over the period 2015–2023 from the Federal Service for Labor and Employment (Rostrud) and prepared two cleaned datasets covering 83 regions of Russia. Dataset 1 is on the educational and career trajectories (N = 6,221,439) and Dataset 2 is on the activity of unemployed and job-seeking candidates (N = 7,662,089).
Feasibility of preventing massive contrast media extravasation using a sensor device in contrast-enhanced CT: an observational study
Authors: Matsumoto Yoriaki , Chikasue Ayaka , Kondo Miho , Akita Tomoyuki , Kiguchi Masao , Nakamura Yuko , Awai Kazuo 
Published: October 2024

Background Recent guidelines recommend direct patient observation, pressure monitoring, and sensor devices to prevent extravasation during contrast media (CM) injection. However, it is impractical in terms of time and cost to install sensors for all patients. Purpose To identify risk factors for CM extravasations during contrast-enhanced computed tomography (CECT) in a large population and to establish criteria for placing the sensor device on patients. Material and Methods This retrospective study included 143,556 patients who underwent CECT at our hospital between April 2012 and July 2022. We performed multivariable logistic regression analysis between patients with (n = 350) and randomly selected patients without CM extravasation (n = 350). We investigated the percentage of patients with sensor devices and their sensitivity for detecting extravasation using receiver operating characteristic curve analysis. Results The extravasation rate was 0.27%. Multivariable logistic regression analysis showed that the injection rate (adjusted odds ratio [AOR] = 1.61, 95% confidence interval [CI] = 1.33–1.95: P <0.001), catheter gauge (AOR = 3.86, 95% CI = 1.92–7.76; P <0.001), the use of anticancer drugs (AOR = 1.81, 95% CI = 1.32–2.50; P <0.001), and existing catheters (AOR = 1.52, 95% CI = 1.10–2.11; P = 0.009) were significantly associated with extravasation. To achieve a sensitivity of 90%, 80%, 70%, 60%, and 50%, 80%, 65%, 50%, 40%, and 28% of all patients required the placement of a sensor device, respectively. Conclusion Sensitivity analysis established criteria for effective placing sensor devices.
Proton therapy for pediatric malignancies: Indications and challenges focusing on the oncological landscape
Authors: Vennarini Sabina , Colombo Francesca , Filippi Andrea R , Orlandi Ester 
Published: October 2024

Advances in therapeutic techniques and multimodal approaches have significantly improved the success rates of treatment for pediatric malignancies, with cure rates now close to 80%. This has led to an increase in long-term survival, with 0.10-0.15% of the general population being survivors of childhood cancer. In Italy, cancer registry data suggest that 75% of treated children become long-term survivors. However, these survivors face significant risks of late adverse events, including chronic diseases and severe conditions, highlighting the need for specialized follow-up care. Radiotherapy, a cornerstone of pediatric cancer treatment, contributes to late toxicities due to the susceptibility of growing tissues. Proton therapy offers advantages in reducing treatment-related toxicity, reducing the risk of secondary cancers, and allowing dose escalation for radioresistant tumors. Comparative studies suggest that proton therapy is superior in sparing healthy tissues and reducing long-term toxicities. Despite these benefits, challenges such as the high cost, limited proton therapy centers, and the need for clinical trials hinder the widespread adoption of proton therapy. Efforts to centralize care in high-ranking centers and ensure equitable access to proton therapy are crucial. In Italy, pediatric solid tumors are now eligible for proton therapy under national health policies, ensuring free access for all children. Dedicated proton therapy centers must provide comprehensive care involving multidisciplinary teams and supportive environments for pediatric patients and their families. Addressing current limitations and enhancing care environments are essential for improving outcomes for pediatric oncology patients.
A Most Neoliberal Encounter: When Covid-19 Met the British Welfare State
Authors: Fourton Clémence 
Published: October 2024

This article explores how the British welfare state was mobilized in the United Kingdom’s response to the Covid-19 pandemic in the context of neoliberal capitalism. This response was conditioned by neoliberal dynamics that had previously shaped the British welfare state, with low investment in healthcare as a case study. The crisis response itself reproduced and amplified neoliberal dynamics, such as poorly accountable contracting out in healthcare. The pandemic context allowed some of these dynamics to be made more visible to the general public, and therefore more questionable, although, as is shown with the example of the benefit system, no overhaul of the system ensued. Ultimately, the Covid-19 pandemic has not been a game changer for the British neoliberal welfare state. JEL Classification: P1, I1
Peripheral mononuclear cells and systemic lupus erythematosus association: Integrated study of single-cell sequencing and mendelian randomization analysis
Authors: Jian Shi , Li Han 
Published: October 2024

Objective Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease predominantly affecting women. Despite advances in treatment, recent developments in single-cell RNA sequencing (scRNA-seq) and Mendelian randomization (MR) continue to facilitate the need for precision medicine. Methods Data obtained from the GSE135779 dataset underwent quality control, normalization, and dimensionality reduction using Seurat and MonacoImmuneData. Marker genes identified subgroups for analysis with CellChat and ClusterProfilerR. MR analysis of these genes’ eQTLs was performed to establish causal relationships with SLE using IEU Open GWAS project data. Results Single-cell analysis revealed distinct cellular subtypes and highlighted increased monocyte levels in patients with SLE. MR analysis revealed 12 genes, particularly interferon induced protein with tetratricopeptide repeats 3 (IFIT3), causally related to SLE. Gene ontology and the Kyoto encyclopedia of genes and genomes analyses identified pathways significant to SLE pathogenesis. Visualization of these genes at the single-cell level revealed their role in disease progression. Cell communication differences between IFIT3-positive and -negative groups were also observed. Conclusion This study demonstrates the potential of scRNA-seq and MR in identifying critical factors in SLE pathogenesis, thereby supporting the need for targeted therapies. Identifying IFIT3, among other genes, as central to SLE progression opens new avenues for precision medicine approaches in SLE management.
Safety of Peripherally Infused Sympathomimetic Vasopressors in the Intensive Care Unit and Emergency Department
Authors: Zichichi Albert , Wallace Ryan , Daniell Jessica , Rouse Ginger , Ahearn Paul , Ammar Mahmoud 
Published: October 2024

Background: Sympathomimetic vasopressors may be administered through a peripheral catheter, but there are limited data available on the safety of peripheral use. Objective: The purpose of this study was to analyze the safety of peripherally infused sympathomimetic vasopressors. Methods: A multicenter, retrospective observational study was conducted to evaluate patients who received peripheral vasopressors. The study’s primary outcome was to assess the incidence of extravasation during the administration of peripheral vasopressors. Secondary outcomes include avoidance of central venous catheter (CVC) placement and institution protocol deviations. Results: There were 198 patients included in the study, of which 142 patients received norepinephrine, 48 patients received phenylephrine, and 8 patients received epinephrine peripherally. Extravasation events occurred in 11 (5.6%) patients. Seven patients required a pharmacologic antidote and 10 patients required a warm compress. No significant differences were seen in characteristics of patients who extravasated compared with those who did not. Protocol deviations identified during the study included 24 (12.1%) patients receiving doses above the protocol maximum, 19 (9.6%) with a body mass index above the protocol maximum, and 45 (22.7%) patients receiving peripheral vasopressor over 24 hours. The majority of patients were able to avoid CVC placement (59.1%). Conclusion and Relevance: Peripherally infused sympathomimetic vasopressors are safe to administer up to 24 hours with a low incidence of extravasation events while avoiding CVC placement in the majority of patients.
Are we advancing the quality of social work research?: An assessment of quantitative research published in social work journals
Authors: Hendrix Elizabeth , Koelling Elisabeth , Barusch Amanda , Abu-Bader Soleman , Gringeri Christina 
Published: October 2024

Summary Social work has grappled with quality of its knowledge base for over a hundred years. In the tradition of critical self-examination, this study was conducted to describe the methods employed in quantitative studies published in social work journals and to assess the extent to which they conform to widely accepted standards of quality. A random sample of 120 articles published in the top thirteen social work journals from 2010 to 2015 were reviewed to identify indicators of quality and rigor. Additional data on citations per year were collected through July 2022. Findings Most studies were cross-sectional and descriptive in nature (62%). While the majority of articles addressed the limitations of the study, only 40% contained reference to theory and 15% described how missing data were handled. Citations per year averaged 4.82, and citations per year exhibited a small, statistically significant positive association with quality indicators and reviewer global evaluations, but not with journal impact factor. Results did underscore the role of doctoral programs in promoting quality research. Applications Social work education programs should continue emphasizing quality social work research methodologies, particularly given the move toward postpositivism as a profession. We note a cycle of disincentivization may be occurring, where social work researchers take their best work to higher impact factor, non-social work journals. We also suggest lack of traditional indicators of rigor may be the result of “concerted resistance” to borrowed epistemologies; we call for consensus-based measures of rigor that reflect the realities of the social work profession.
Impairments in Proprioceptively-Referenced Limb and Eye Movements in Chronic Stroke
Authors: Tulimieri Duncan T. , Decarie Amelia , Singh Tarkeshwar , Semrau Jennifer A. 
Published: October 2024

Background Upper limb proprioceptive impairments are common after stroke and affect daily function. Recent work has shown that stroke survivors have difficulty using visual information to improve proprioception. It is unclear how eye movements are impacted to guide action of the arm after stroke. Here, we aimed to understand how upper limb proprioceptive impairments impact eye movements in individuals with stroke. Methods Control (N = 20) and stroke participants (N = 20) performed a proprioceptive matching task with upper limb and eye movements. A KINARM exoskeleton with eye tracking was used to assess limb and eye kinematics. The upper limb was passively moved by the robot and participants matched the location with either an arm or eye movement. Accuracy was measured as the difference between passive robot movement location and active limb matching (Hand-End Point Error) or active eye movement matching (Eye-End Point Error). Results We found that individuals with stroke had significantly larger Hand (2.1×) and Eye-End Point (1.5×) Errors compared to controls. Further, we found that proprioceptive errors of the hand and eye were highly correlated in stroke participants ( r = .67, P = .001), a relationship not observed for controls. Conclusions Eye movement accuracy declined as a function of proprioceptive impairment of the more-affected limb, which was used as a proprioceptive reference. The inability to use proprioceptive information of the arm to coordinate eye movements suggests that disordered proprioception impacts integration of sensory information across different modalities. These results have important implications for how vision is used to actively guide limb movement during rehabilitation.