bluuebunny/crossref_metadata_2025_split huggingface dataset:
The perspectives of Māori on community treatment orders: A thematic analysis
Authors: Kirikiri Arahia , Young Greg , Beaglehole Ben , Newton-Howes Giles 
Published: September 2024

Aim: To understand the themes for Māori subjected to compulsory community treatment orders. Background: The Mental Health (Compulsory Assessment and Treatment) Act 1992 has been utilised in Aotearoa New Zealand for more than three decades. Despite Māori having higher rates of being subject to community treatment orders, there is little research examining their perspectives of its benefits and harms. Methods: Thematic analysis of a purposive sample of Māori in Hawke’s Bay, New Zealand. Results: Five themes were developed. Māori described community treatment orders as restrictive and stigmatising. Some Māori described being poorly informed of the structures surrounding the use of community treatment orders and saw it as a mechanism to circumvent information-giving regarding treatment. Counterbalancing these, Māori described community treatment orders as mandating support and saw them as a mechanism to access care. Finally, some described their compulsory treatment status as unimportant and irrelevant. Conclusions: Thematic analysis identified five clear themes from interview participants. Conceptualisation of community treatment orders was largely negative, although Māori acknowledged that being subject to community treatment orders demanded more support from services. Themes of stigma and restriction are common in the literature, however, conception of the use of community treatment orders to bypass consent is novel. The literature describes community treatment orders as providing support, however, in this study, the interpretation suggests a need to lose personal autonomy to receive care, a potentially ‘slippery slope’ towards a two-tier type service. These findings remind services of the importance of attending to cultural elements of care, being clear around the process of consent. In terms of policy, weaving in cultural understanding appears to be important from an Indigenous perspective.
Psychometric properties evaluation of the Persian version of the self-report outcome scale for lupus disease Lupus_PRO version 1.7
Authors: Mahmoudzadeh Bahareh , Mohammadian Youkhabeh , Assar Shirin , Ahmadi Seyyed Mojtaba 
Published: September 2024

Purpose Systemic Lupus Erythematosus (SLE) significantly affects both the quality of life related to health and non-health aspects. This study aims to evaluate the psychometric properties of the Persian version of the Lupus_PRO questionnaire, version 1.7. The questionnaire serves as a specific self-report outcome scale for assessing the treatment outcomes of Lupus disease. Methods The Lupus_PRO questionnaire, version 1.7, was translated into Persian using the standard forward-backward method. After being completed by 218 patients with Lupus, the psychometric properties of the instrument were examined. The Convergent and Discriminant Validity of the scale were assessed using Average Variance Extracted and Cross Loadings, respectively. The construct validity of the questionnaire was also evaluated through Confirmatory Factor Analysis (CFA). Cronbach’s alpha was calculated to assess the reliability of the questionnaire dimensions. Findings Out of the 218 patients with lupus who participated in the current study, 13 (6%) were male, and 205 (94%) were female. The mean (SD) age of participants was 40.29 (10.94) years. The Average Variance Extracted (AVE) for HRQOL and Non-HRQOL constructs, except for the Coping and Cognition dimension, was greater than 0.50, indicating satisfactory convergent validity. The interdimensional correlation coefficient (Discriminant Validity) for each dimension with other questionnaire dimensions was less than 0.10, indicating that the questionnaire has good convergent and discriminant validity. Additionally, the results of the Confirmatory Factor Analysis (CFA) indicated that the questionnaire was a suitable fit. In terms of reliability, Cronbach’s alpha for the various questionnaire dimensions ranged from 0.51 to 0.91, indicating good internal consistency. Conclusion The Persian version of the Lupus_PRO questionnaire, version 1.7, demonstrates acceptable validity and reliability in the Iranian population. This instrument can effectively measure various aspects of the quality of life in patients with lupus.
Clinical outcomes and complications of a non-modular dual-mobility acetabular device, minimum 2 years follow-up
Authors: Todderud Julia E , Holbrook Lauren , Scott David F 
Published: September 2024

Introduction: Non-modular dual-mobility (DM) acetabular bearing constructs are becoming more popular due to their potential advantages for addressing range of motion (ROM) and stability. The objective of this post-market clinical study was to assess clinical outcomes, including patient satisfaction, pain and function, survivorship, and component positioning, in patients ⩾2 years after primary THA using non-modular DM acetabular components. Methods: This retrospective, multicentre study evaluated complications and functional outcomes in recipients of non-modular DM acetabular constructs at least 2 years post-THA. Our primary outcomes included the dislocation rate and mean Hip disability and Osteoarthritis Outcomes Score (HOOS). Secondary outcomes included radiographic measurements, patient satisfaction, Forgotten Joint Score (FJS), Harris Hip Score (HHS), and survivorship. Results: 316 eligible patients enrolled in this study across 3 sites, including 168 men (53%) and 148 women (47%). The cohort averaged 5.37 years post-THA (range 2.2–10.1 years) at the study visit. The mean FJS, HHS, and HOOS were good to excellent, with values of 82.3, 90.7, and 92.0, respectively. Patient satisfaction averaged 4.68, between “Very Good” (4) and “Excellent” (5). Minimal radiolucent lines (RLL) surrounded the acetabulum. More RLL surrounded the femur, but most lines were less than 1 mm (4.7% of the study population). There were few adverse events (4 events, 1.3%). Three revisions were performed (0.9%), with one patient requiring removal of the acetabular cup. Discussion: The high mid- to long-term survivorship and low to no dislocation and reoperation rates indicate this acetabular DM device is a viable option for THA patients. The patient metrics reflect satisfaction, alleviated pain, and restored function with a low risk of adverse outcomes.
Multiple sclerosis and cancer: Navigating a dual diagnosis
Authors: Nesbitt Cassie , Van Der Walt Anneke , Butzkueven Helmut , Devitt Bianca , Jokubaitis Vilija G 
Published: September 2024

Healthcare breakthroughs are extending the lives of multiple sclerosis (MS) patients and cancer survivors, creating a growing cohort of individuals navigating a dual diagnosis. Determining the relationship between MS and cancer risk remains challenging, with inconclusive findings confounded by age, risk exposures, comorbidities, genetics and the ongoing introduction of new MS disease-modifying therapies (DMTs) across study periods. This research places significant emphasis on cancer survival, with less attention given to the impact on MS outcomes. Our review explores the existing literature on MS, cancer risk and the intersection of DMTs and cancer treatments. We aim to navigate the complexities of managing MS in cancer survivors to optimise outcomes for both conditions. Continuous research and the formulation of treatment guidelines are essential for guiding future care. Collaboration between neuro-immunology and oncology is crucial, with a need to establish databases for retrospective and ultimately prospective analysis of outcomes in these rapidly evolving fields.
Silver-plated stretchable elastomeric electrodes for electrotherapy applications
Authors: Ali Azam , Tomkova Blanka , Islam Saharin , Farooq Assad , Howari Haidar , Subrova Tereza , Wiener Jakub , Militky Jiri 
Published: September 2024

The present study aimed to develop wearable, electrically conductive hygienic electrodes and their use for Transcutaneous Electrical Nerve Stimulation (TENS) application. The development of electrodes was done in two stages. Firstly, the dispersion of conductive activated carbon particles was done into flexible elastomer followed by its silver electroplating. The Orthogonal Array Testing (OATS) technique was used to optimize the silver-plating recipe. The Fourier transform infrared spectroscopy (FTIR) analysis confirmed the impact of activated carbon by increase in intensity of stretching bands. To improve electrode properties in response to various human body movements, resistivity changes due to stretching and repeated extension were tested on conductive elastomers. Increasing the extension degree allowed a very minute change in electrical resistivity. Therefore, the resistivity can be considered almost constant within the 0-60 % stretch range. While, a notable increase in electrical resistivity was observed after 70 % of stretch. However, the resistivity of elastomers remained stable even after repetitive extension (for over 100 cycles). Conversely, no significant change in resistivity was observed over time when subjected to a constant current. Furthermore, to minimize the effect of skin electrode resistivity during electrotherapy, the range of different pressure was applied over the surface of electrodes. Minimum value of resistivity about 1 Ω.mm was obtained at 6 N/cm2 of applied pressure. Additionally, hygienic properties, such as antiviral, antibacterial and antifungal were examined using different pathogens to assess the impact of the deposited silver particles. In the end, the durability of electrodes against washing and rubbing was confirmed. The potential applications of prepared electrodes are in the field of electrostimulation and electrotherapy etc.
Role of Olive Leaf Extract, Mesenchymal Stem Cells or Low Radiation Dose in Alleviating Hepatic Injury in Rats
Authors: Gharib Ola A. , Fahmy Hanan A. , Abdou Fatma Y. 
Published: September 2024

Objectives This study was conducted to determine the efficacy of mesenchymal stem cells (MSCs) or low-dose gamma radiation (LDR) on liver injury compared to the effect of olive leaf extract as a hepatoprotective agent. Methods Rats were allocated into six groups; group I served as the negative control. Group II received 5% dextran sodium sulfate (DSS) in its drinking water for 1 week. Group III was injected with a single dose of 1 × 106 bone marrow-derived mesenchymal stem cells (BM-MSCs) intravenously. Group IV was treated as in group III after 5% DSS treatment. Group V was given 5% DSS, followed by olive leaf extract (OLE) (1000 mg/ kg, oral). Group VI: 5% DSS for 1 week, then was exposed to low-dose gamma radiation (LDR) (0.05 Gy). Results Rats treated with OLE, BM-MSCs, or exposed to LDR exerted significant alleviation in all hepatic biomarkers, significant enhancements in oxidative stress parameters, and improvements in inflammatory biomarkers Interleukin-1 beta (IL-1β) and Interferon gamma (INF-γ) hepatic contents compared with those of the DSS group. Histological pictures emphasized the biochemical findings. Conclusions BM-MSCs might be a valuable therapeutic approach to overcome hepatic injury. Exposure to LDR provided protective mechanisms that allow the body to survive better.
The Incidence of Injuries to Ramp Semimembranosus Complex Lesions After ACL Injury: An MRI Study
Authors: Druel Julien , Jacquet Christophe , Escudier Jean-Charles , Desmaison Chloé , Raghbir Khakha , Ollivier Matthieu , Guenoun Daphné 
Published: September 2024

Background: Medial meniscal ramp lesions have recently been an area of interest because of their recognized prevalence in association with anterior cruciate ligament (ACL) ruptures. Anatomically, the medial meniscal ramp is composed of the meniscocapsular ligament in continuity with the semimembranosus muscle and the meniscotibial ligament. Diagnosis of ramp semimembranosus complex (RSC) injuries remains challenging, and their prevalence is likely to be underestimated in comparison with ramp lesions. Purpose: To determine the prevalence of RSC lesions after a complete ACL rupture. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A retrospective database analysis was performed. The cohort consisted of the first 100 patients with complete ACL rupture confirmed by magnetic resonance imaging (MRI) who underwent knee arthroscopy for ACL reconstruction in 2019. The semimembranosus lesions were identified using MRI by 2 independent radiologists specializing in musculoskeletal imaging. The ramp lesions were initially diagnosed using MRI and then confirmed during arthroscopy by an experienced knee surgeon. The magnitude of rotatory instability was recorded using the pivot-shift test. A multivariate analysis was used to determine the lesions associated with the semimembranosus complex. Results: Of 100 patients, 53 showed lesions of the RSC; among them, 30 ramp lesions were confirmed after arthroscopic evaluation, and 40 semimembranosus lesions (23 without ramp lesion and 17 with ramp lesion) were found using MRI. A positive pivot shift was present in 57% of patients with combined RSC injury ( P = .04) compared with 36% in patients without an RSC lesion. Conclusion: Lesions of the RSC were found in more than half of ACL ruptures in this retrospective cohort. Rotational instability could be associated with combined ACL and RSC injury.
Immune reconstitution and evolution of B-cell–stimulating cytokines after R-CHOP therapy for HIV-associated DLBCL
Authors: Liévin Raphaël , Maillard Alexis , Hendel-Chavez Houria , Krzysiek Roman , Lancar Remi , Algarte-Genin Michele , Costagliola Dominique , Assoumou Lambert , Taoufik Yassine , Besson Caroline 
Published: September 2024

Abstract
HIV infection is associated with an increased risk of diffuse large B-cell lymphoma (DLBCL). In this prospective study, we analyzed the evolution of B-cell activating cytokines (interleukin-6 [IL-6], IL-10, and B-cell activating factor [BAFF]) and main functional subsets of circulating B and T cells in 51 patients with HIV-associated DLBCL treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, Oncovin [vincristine], and prednisone). R-CHOP therapy was associated with a decrease of IL-10, whereas IL-6 levels fluctuated, and BAFF levels increased during the first 3 months and decreased thereafter. We observed a rapid rise in CD19+ B cells composed mostly of naïve B cells whereas marginal zone–like B cells and memory B cells recovered gradually. With a median follow-up of 41 months, progression-free survival and overall survival at 5 years were 61.8% (95% confidence interval [CI], 47.6-80.4) and 67.4% (95% CI, 53.4-85.0), respectively. Progression (17.5%) and sepsis (12.5%) were the main causes of death. Baseline risk factors for death and progression were poor revised International Prognostic Index (P = .049), natural killer cell lymphopenia (P = .001), lower proportion of naïve B cells (P = .017), and higher IL-6 serum levels (P = .001). Our data suggest that patients treated with R-CHOP for HIV-associated DLBCL have a disturbed peripheral B-cell compartment and that the low pool size of circulating naïve B cells negatively affects their clinical outcome. In an era of development of B-cell–depleting therapies including B-cell–targeting chimeric antigen receptor T cells, assessment of perturbations within nontumoral B-cell counterparts are warranted for risk profiling in HIV-associated DLBCL. This trial was registered at www.ClinicalTrials.gov as #NCT01164436.
Tocilizumab for cystoid macular edema secondary to retinitis pigmentosa
Authors: Abramowicz Stéphane , Kamgang Semeu Prochore , Nubourgh Isabelle , Postelmans Laurence , Willermain François 
Published: September 2024

Abstract
Purpose
To describe the effect of tocilizumab (TCZ) on cystoid macular edema (CME) and retinal vascular leakage (RVL) in retinitis pigmentosa (RP).

Methods
Retrospective case series.

Results
We present 2 cases of RP with marked inflammatory features in the form of CME and RVL. There was initial diagnostic uncertainty with posterior uveitis. Both patients were treated with corticosteroids, conventional disease-modifying antirheumatic drugs (cDMARDs), and biological DMARDs (bDMARDs) for the inflammatory features with partial and inconsistent treatment response. When treatment was switched to intravenous (IV) TCZ, dramatic reduction in CME and RVL were observed in both patients. Diagnosis of RP was eventually made based on findings of ancillary tests (macular spectral-domain optical coherence tomography, visual fields, full-field electroretinogram). Genetic testing led to a molecular diagnosis of EYS-related autosomal recessive RP in patient 1, while patient 2 had negative gene panel results.

Conclusions
IV TCZ can be an effective treatment option in RP-related CME and RVL. Whether this treatment strategy has an effect on prognosis remains to be established, but it is possible considering chronic CME-related retinal damage is a major driver of central vision loss in RP.
Hypoxia increases triacylglycerol levels and unsaturation in tomato roots
Authors: Striesow Johanna , Welle Marcel , Busch Larissa Milena , Bekeschus Sander , Wende Kristian , Stöhr Christine 
Published: September 2024

Abstract
Background
Plants are designed to endure stress, but increasingly extreme weather events are testing the limits. Events like flooding result in submergence of plant organs, triggering an energy crisis due to hypoxia and threaten plant growth and productivity. Lipids are relevant as building blocks and energy vault and are substantially intertwined with primary metabolism, making them an ideal readout for plant stress.

Results
By high resolution mass spectrometry, a distinct, hypoxia-related lipid composition of Solanum lycopersicum root tissue was observed. Out of 491 lipid species, 11 were exclusively detected in this condition. Among the lipid classes observed, glycerolipids and glycerophospholipids dominated by far (78%). Differences between the lipidomic profiles of both analyzed conditions were significantly driven by changes in the abundance of triacylglycerols (TGs) whereas sitosterol esters, digalactosyldiacylglycerols, and phosphatidylcholine play a significantly negligible role in separation. Alongside, an increased level of polyunsaturation was observed in the fatty acid chains, with 18:2 and 18:3 residues showing a significant increase. Of note, hexadecatetraenoic acid (16:4) was identified in hypoxia condition samples. Changes in gene expression of enzymes related to lipid metabolism corroborate the above findings.

Conclusion
To our knowledge, this is the first report on a hypoxia-induced increase in TG content in tomato root tissue, closing a knowledge gap in TG abiotic stress response. The results suggest that the increase in TGs and TG polyunsaturation degree are common features of hypoxic response in plant roots.
Assessing vaccine strategies for mpox outbreak in New York City using an age-structure model
Authors: Xiong Zixiao , Xue Ling , Li Xuezhi , Zhang Yanfen 
Published: September 2024

Abstract
Background
Since May 7 2022, mpox has been endemic in many countries which has attracted the attention of health authorities in various countries and made control decisions, in which vaccination is the mainstream strategy. However, the shortage of vaccine doses and the reduction of protective efficacy have led to unresolved issues such as vaccine allocation decisions and evaluation of transmission scale.

Methods
We developed an epidemiological model to describe the prevalence of the mpox virus in New York City and calibrated the model to match surveillance data from May 19 to November 3, 2022. Finally, we adjusted the model to simulate and compare several scenarios of non-vaccination and pre-pandemic vaccination.

Results
Relative to the status quo, if vaccination is not carried out, the number of new infections increases to about 385%, and the transmission time will be extended to about 350%, while if vaccinated before the epidemic, the number of new infections decreases to 94.2-96%.

Conclusions
The mpox outbreak in New York City may be linked to the Pride event. However, with current vaccine coverage, there will be no more large-scale outbreaks of mpox, even if there is another similar activity. For areas with limited vaccines, priority is given to high-risk groups in the age group [34–45] years as soon as possible.
The requirements of providing health education for rural people through electronic methods: the experiences and perspectives of community health workers
Authors: Hosseini Seyed Hadi , Tayebi Zahra , Amerzadeh Mohammad , Pouragha Behrooz , Hatefnia Effat , Moeini-Mostofi Shahab , Hosseini Seyedeh Sedreh , Poormoosa Yasaman 
Published: September 2024

Abstract
Background
Reliance solely on traditional approaches in health education is no longer considered sufficient, and electronic/digital education can be a complementary approach. Implementing electronic methods in health education requires identifying the requirements from the perspective of the service providers. Therefore, this study aimed to elucidate the experiences and perspectives of community health workers (Behvarzan) regarding the requirements for providing health education for rural people through electronic/digital means.

Methods
This descriptive qualitative study was conducted in 2022 at Alborz University of Medical Sciences. Data were collected through semi-structured interviews with 14 Behvarzan from Health Houses (HH) in Karaj City. The data were analyzed using the inductive Elo & Kyngas approach and conventional content analysis facilitated with MAXQDA software.

Results
After analyzing the results, we extracted 139 open codes, and by merging them for more precise coding and to facilitate the research process, we formed three main themes and ten subthemes. The themes included Technology (technical infrastructure, content production, content delivery methods, and content delivery channels), Facilities and equipment (communication equipment and electronic content repositories), and Stakeholders (training of providers, motivating providers, persuading learners and target groups, and reference groups).

Conclusion
From the perspective of rural healthcare workers, the implementation of electronic education requires necessary technology, equipment, facilities, processes, and content should be pursued and provided through specialized working groups, extending from the Ministry of Health and Medical Education to local HHs. These resources should be available to the healthcare workers and their target populations. Concurrently, educational programs and incentives should be defined and offered at the university level and within health networks for rural healthcare workers and their populations.