bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective study on symptom generation according to spicy food intake and TRPV1 genotypes in functional dyspepsia patients
Authors: Lee S.‐Y. , Masaoka T. , Han H. S. , Matsuzaki J. , Hong M. J. , Fukuhara S. , Choi H. S. , Suzuki H. 
Published: April 2016

AbstractBackgroundCapsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (TRPV1), and Koreans eat more capsaicin‐rich food than do Japanese. This study aimed to compare symptom generation according to TRPV1 genotypes and the intake of spicy foods.MethodsConsecutive functional dyspepsia (FD) patients who were evaluated at Konkuk University Medical Centre (Korea) and Keio University Hospital (Japan) were included. Questionnaires on spicy food intake, patient assessment of gastrointestinal symptoms (PAGI‐SYM), patient assessment of quality of life, and hospital anxiety and depression scale were provided. Blood was sampled for the detection of TRPV1 polymorphisms, and upper gastrointestinal endoscopy was performed with biopsies.Key ResultsOf 121 included subjects, 35 and 28 carried the TRPV1 CC and GG genotypes, respectively, with the prevalence rates not differing between Japan and Korea. The prevalence of FD subtypes did not differ with the spicy food intake, TRPV1 genotypes, or Helicobacter pylori infection. Neither TRPV1 polymorphisms nor H. pylori infections were related to scores on the PAGI‐SYM questionnaires, but spicy food intake was positively correlated with the scores for stomach fullness (p = 0.001) and retching (p = 0.001). Using the linear regression analysis, stomach fullness was associated with spicy food intake (p = 0.007), whereas retching was related to younger age (p < 0.001) and female gender (p = 0.014).Conclusions & InferencesUpper gastrointestinal symptoms are more common in subjects with a higher consumption of spicy foods, younger age and female gender, regardless of TRPV1 genotypes and the H. pylori infection status. Capsaicin‐rich foods may induce stomach fullness.
Warming benefits a native species competing with an invasive congener in the presence of a biocontrol beetle
Authors: Lu Xinmin , Siemann Evan , He Minyan , Wei Hui , Shao Xu , Ding Jianqing 
Published: April 2016

Summary

Climate warming may affect biological invasions by altering competition between native and non‐native species, but these effects may depend on biotic interactions.

In field surveys at 33 sites in China along a latitudinal and temperature gradient from 21°N to 30.5°N and a 2‐yr field experiment at 30.5°N, we tested the role of the biocontrol beetle Agasicles hygrophila in mediating warming effects on competition between the invasive plant Alternanthera philoxeroides and the native plant Alternanthera sessilis.

In surveys, native populations were perennial below 25.8°N but only annual populations were found above 26.5°N where the invader dominated the community. Beetles were present throughout the gradient. Experimental warming (+ 1.8°C) increased native plant performance directly by shifting its lifecycle from annual to perennial, and indirectly by releasing the native from competition via disproportionate increases in herbivory on the invader. Consequently, warming shifted the plant community from invader‐dominated to native‐dominated but only in the presence of the beetle.

Our results show that herbivores can play a critical role in determining warming effects on plant communities and species invasions. Understanding how biotic interactions shape responses of communities to climate change is crucial for predicting the risk of plant invasions.
Nationwide survey of neonatal transportation practices in Japan
Authors: Hiroma Takehiko , Ichiba Hiroyuki , Wada Kazuko , Shiraishi Jun , Sugiura Hiroshi , Nakamura Tomohiko 
Published: April 2016

AbstractRapid resuscitation and appropriate transportation of sick infants can greatly improve infant survival and neurological prognosis. To gain an understanding of the status of neonatal transport in Japan, we conducted a survey of neonatal transportation capabilities at perinatal medical centers across the country. Survey content included the number of neonatal transportation cases and the method of transportation. Twenty percent of infants admitted to neonatal intensive care units were transported to the medical centers from other institutions. Half of the level III perinatal medical centers owned an ambulance specialized for neonatal transport. A total of 36% of sick newborns, however, were transported by fire department ambulances that are ill‐equipped to care for infants. Thirteen percent of centers reported problems with the emergency transportation of newborns in fire department ambulances. Centers lacked specialized ambulances primarily because of financial constraints. Adequate medical insurance coverage is needed to increase the number of specialized ambulances at perinatal medical centers.
Identification of glucose‐regulated protein 78 (grp78) cDNA from Aphis gossypii and its expression during development, heat shock and nutritional ingestion
Authors: Cha Sangmok , Shim Jae‐Kyoung , Lee Kyeong‐Yeoll 
Published: April 2016

AbstractGlucose‐regulated protein 78 (GRP78) is a heat shock protein 70 (HSP70) specific to the endoplasmic reticulum (ER). It acts as a chaperone and a signalling regulator that responds to ER stresses in vertebrates. However, its role in invertebrates, including in insects, is uncertain. The present study determines the full grp78 cDNA sequence and expression patterns of grp78 in Aphis gossypii Glover, which is a major pest of numerous crop plants worldwide. The A. gossypii grp78 cDNA contains highly conserved motifs of the HSP70 family, as well as the C‐terminal KDEL motif that is characteristic of ER‐specific HSPs. The amino acid sequence also exhibits 97–98% identity with HSP70 of other aphid species. Quantitative real‐time reverse transcriptase‐polymerase chain reaction analysis shows that the grp78 level is higher in fourth‐instar nymphs than in the younger instar‐nymphs and adults. Its level is not significantly affected by exposure to 0–40 °C for 1 h. The grp78 level gradually increases after ingestion of sucrose solutions that range in concentration from 0% to 30% (w/v) using Parafilm feeding chambers. In addition, the grp78 levels vary among aphids that are fed on the leaves of 13 different plant species for 24 h. More specifically, grp78 levels are higher in aphids that fed on eggplant and pepper than any other host plants examined in the present study. Thus, the results demonstrate that grp78 expression is highly associated with the nutritional uptake of aphids and provide important insights for understanding the molecular aspects of relationships between insects and their host plants.
Proteomic and Physiological Studies Provide Insight into Photosynthetic Response of Rice (Oryza sativa L.) Seedlings to Microgravity
Authors: Chen Boya , Wang Yingping 
Published: April 2016

AbstractThe mechanisms whereby how photosynthesis is regulated and maintained under conditions of microgravity remain incompletely understood. Herein, we took a combination of proteomic and physiological approaches to examine the response of rice (Oryza sativa L.) seedlings to spaceflight conditions. Our results show that both PSI fluorescence emission peak and P700 absorbance amplitude are severely decreased in spaceflight seedlings under microgravity. This is consistent with an observed significant reduction in PSI efficiency (ϕI). To further analyze global changes of protein profiles under microgravity, isobaric tags for relative and absolute quantization (iTRAQ) labeling technology were deployed. Four hundred fifty‐four differentially expressed proteins were identified by comparison of spaceflight and ground control. Of proteins relevant to photosynthesis, 34 were downregulated and 4 were upregulated. The significantly downregulated ones are essential components of PSI, NDH and the Cytb6f complex. This downregulation of PSI proteins and/or protein structure changes may cause the overall reduction in PSI activity. Intriguingly, although abundance of some PSII proteins was altered under microgravity, no significant changes in PSII activity were detected. Taken together, our results suggest that PSI, rather than PSII being usually much more sensitive to environmental stresses, is more susceptible to spaceflight conditions in rice seedlings.
Frontal asymmetry and alcohol cue reactivity: Influence of core personality systems
Authors: Mechin Nicole , Gable Philip A. , Hicks Joshua A. 
Published: April 2016

AbstractGreater left frontal activation appears to be a measure of appetitive reactivity for desired stimuli, such as alcohol cues. However, inconsistencies in past research examining frontal asymmetry to appetitive stimuli suggest that individual differences strongly influence frontal asymmetry to appetitive stimuli. Because core personality systems of approach, avoidance, and supervisory control play a fundamental role in directing alcohol behavior, the current study sought to determine which core system would influence asymmetric frontal activation to alcohol cues. Results revealed that greater trait impulsivity (reduced functioning of the supervisory control system) is related to greater relative left frontal activation in response to alcohol cues. Approach motivation and avoidance motivation were unrelated to greater relative left frontal activation in response to alcohol cues. These results suggest that decreased activation of the supervisory control system (increased trait impulsivity) is responsible for appetitive reactivity to alcohol cues.
Red blood cells with elevated cytoplasmic Ca2+ are primarily taken up by splenic marginal zone macrophages and CD207+ dendritic cells
Authors: Larsson Anders , Hult Andreas , Nilsson Anna , Olsson Mattias , Oldenborg Per‐Arne 
Published: April 2016

BACKGROUNDThe normal red blood cell (RBC) life span may be significantly reduced when RBCs are stored under blood bank conditions, resulting in a reduced 24‐hour survival after transfusion. The damage of stored RBCs is probably multifactorial as stored RBCs share features of both senescence and suicidal RBC death (eryptosis). Since an increased intracellular Ca2+ concentration ([Ca2+]i) is one key feature of eryptosis, we here investigated if stored human RBCs had increased [Ca2+]i and the mechanisms behind uptake of such RBCs in a murine model.STUDY DESIGN AND METHODSThe intracellular Ca2+ content of RBCs was determined using the Ca2+ probe Fluo‐3 and flow cytometry. In vivo uptake of Ca2+ ionophore–treated murine RBCs (Ca2+‐RBCs) was investigated in recipient mice, using flow cytometry and immunohistochemical analysis.RESULTSA small fraction of human RBCs accumulated [Ca2+]i during storage for up to 42 days under blood bank conditions. In a murine model, where fresh or Ca2+‐RBCs were transfused, Ca2+‐RBCs were mainly trapped by MARCO+ splenic marginal zone macrophages and CD11c+ CD207+ dendritic cells (DCs) within 1 hour after transfusion. In marked contrast, freshly transfused RBCs aging normally in circulation were cleared much slower and preferentially by F4/80+ red pulp macrophages. CD47 on the Ca2+‐RBCs did not affect their clearance by splenic phagocytic cells.CONCLUSIONSA small fraction of RBCs accumulate [Ca2+]i during storage, and in a murine model such RBCs are recognized by splenic macrophages and DCs in ways similar to what has been reported for nucleated apoptotic cells.
CANCER PREVENTION INITIATIVE: AN INTELLIGENT APPROACH FOR THYROID CANCER TYPE DIAGNOSTICS
Authors: Ahmed Jamil , Rehman M. Abdul 
Published: April 2016

In recent, medical Image mining has witnessed to be one of the emerging fields of machine learning. Particularly; the classification problem of DICOM (Digital Imaging and Communications in Medicine) images has become a prominent challenge. Thyroid cancer must be detected as earlier as possible; a little delay would extremely be proved hazards for human health and may be resulted into the most fatal threat to human life. Infect in-depth study of physical components of cells of FNAB (Fine needle aspiration Biopsy) would help to refine the results and provide more precise decisions about the potential occurrences of cancer, this paper proposes a system, so called ‘TCTD’ (Thyroid Cancer Type Diagnostics), which aims to assist the doctors during their diagnostic process conducted for thyroid follicular carcinoma and its sub-types. There are five main steps of our methodology. In first step image pre-processing techniques are used. In the second step; we use ensemble methods, such as Multi-SVM to build decision model and to analyze the frequencies between the variables. In third, fourth and fifth steps, model testing, result visualization and performance evaluation are performed by using precision, recall and f-measure estimations. The measured classification accuracy of proposed system is about 98.50% using 10 K-fold cross validation.
ASSESSMENT OF UNDERSTOREY VEGETATION OF MALAM JABBA FOREST, KPK AFTER CLEANUP OPERATION USING MULTIVARIATE TECHNIQUES
Authors: Siddiqui Muhammad Faheem , Arsalan Arsalan , Ahmed Moinuddin , Hussain Muhammad Ishtiaq , Iqbal Javed , Wahab Muhammad 
Published: April 2016

In this study vegetation composition of understorey species of Malam Jabba forest is evaluated by multivariate analysis. Thirteen stands were quantitatively sampled by point centered quarter method. Environmental variables were recorded and correlate them with vegetation characteristic. In 13 stands 49 understory species were recorded. Multivariate techniques were employed to assess the vegetation groups and underlying group structure. Agglomerative Cluster analysis (Ward’s method) discloses four main groups of vegetation while Principle Component Analysis (PCA) clearly ordinate these groups on all three axes. The most common species distributed in all four groups were Adiantum capillus veneris, Adiantum venestum, Berberis lyceum, Chrysopogon aucheri, Oxalis corniculata, Pteris cretica and Trifolium repens while these species were observed in three groups i.e. Punica granatum and Plantago amplexicaulis. The Group 1 comprises on 23 species and the dominant species were Androsace rotundifolia, Aristida cynantha, Berberis lyceum, Dryopteris filix, Oxalis corniculata, Pteris cretica and Trifolium repens while Group 2 comprises on 18 species, the dominant were Pteris cretica, Adiantum venestum, Duchesnea indica while some other species included, Berberis lyceum, Chrysopogon aucheri, Chrysopogon aucheri, Dryopteris juxtapostia and Morus alba. Group 3 & 4 comprises 31 species each, in which 18 species were common i.e. Adiantum capillus veneris, Adiantum venustum, Arisaema jacquemontii, Berberis lyceum, Chrysopogon aucheri, Dryopteris filix, Dryopteris juxtapostia, Duchesnea indica, Oxalis corniculata, Plantago amplexicaulis, Polygala erioptera, Prunus avium, Pteris cretica, Punica granatum, Ranunculus muricatus, Rosa macrophylla, Trifolium fragiferum and Trifolium repens. Among the environmental variables elevation and slope played an overriding role in the distribution of vegetation. The relationships between the six PCA ordination axes with environmental factors generally showed few significant relations, only axis 2 showed marked relationship with all edaphic variables (except pH), suggesting that the edaphic gradient has an overriding role in the composition and distribution of understorey vegetation. Some other environmental factors showed weak correlations with ordination axes, it could be spurious correlation. Malam Jabba forests are highly disturbed due to civil war and anthropogenic causes. Slope of the forests prove to be an overriding role in the distribution of vegetation as evaluated by analysis of variance.
Reviewer Acknowledgements
Authors: Gibbs Nikki 
Published: April 2016

Applied Economics and Finance [AEF] would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether AEF publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 3, Number 1 Ali Massoud Arash Riasi Dimitrios Vortelinos George Theocharides Getamesay Bekele Ghazi Al-Assaf Haitham Nobanee Ian McFarlane Igor Matyushenko Iulia Lupu Jin Yong Yang Jolita Vveinhardt Jose SOLANA IBAÑEZ, Luca Giordano Magdalena Zioło Manuel CARAVACA Mohammed Alkali Yusuf Oluchukwu Anowor Patrycja Kowalczyk-Rólczynska Prof. Dr. Erdal Gumus Ramona Orastean Shahram Fattahi Szabolcs Blazsek Tudor Ciumara Vilas Gaikar Y. SAIDI Zachary A. Smith Nikki Gibbs Editorial Assistant On behalf of, The Editorial Board of Applied Economics and Finance Redfame Publishing 9450 SW Gemini Dr. #99416 Beaverton, OR 97008, USA URL: http://aef.redfame.com
Reviewer Acknowledgements
Authors: Eve Angelia 
Published: April 2016

Applied Finance and Accounting [AFA] would like to thank the following reviewers for reviewing manuscripts from February 1, 2015 to July 31, 2015. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Many authors, regardless of whether AFA publishes their work, appreciate the helpful feedback provided by the reviewers. Redfame Publishing appreciates the following reviewers’ rigorous and conscientious efforts for this journal. Each of the reviewers listed below returned at least one review during this period. Abdelaziz HAKIMI Adam Zaremba Ana Iglesias-Casal Anastasia,Kopaneli Aneta Karina Bernat Augustine Akhidime Desti Kannaiah Feng Jui Hsu Florin Peci Ghazi Alassaf Gheorghe Morosan Haitham Nobanee, Hajar Jahangard Hong Bo Kesseven Padachi Lee Kian Tek Luca Sensini Luo Yongli Marco Muscettola Mazurina Mohd Ali Meri Boshkoska Mohamed Jalloh Nicoleta Radneantu Nikolay Patonov Noriaki Okamoto Odumeso-Jimoh M I John Peibiao Zhao Wei-Bin ZHANG Wilson E. Herbert Rui FERNANDES Shahram Fattahi Vineet Chouhan Yao Zheng Yu Peng Lin
Reviewer Acknowledgements
Authors: Evelyn Angelia 
Published: April 2016

Applied Finance and Accounting [AFA] would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether AFA publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 2, Number 1 Aneta Karina Bernat Augustine Akhidime Feng Jui Hsu Florin Peci Gheorghe Morosan Hajar Jahangard Hong Bo Iulia Lupu Kesseven Padachi Mazurina Mohd Ali Nicoleta Radneantu Noriaki Okamoto Odumeso-Jimoh M I John Professor Wilson E. Herbert Rui Fernandes Vineet Chouhan Angelia Evelyn Editorial Assistant On behalf of, The Editorial Board of Applied Finance and Accounting Redfame Publishing 9450 SW Gemini Dr. #99416 Beaverton, OR 97008, USA E-mail: afa@redfame.com URL: http://afa.redfame.com
Repetitive cryotherapy attenuates the in vitro and in vivo mononuclear cell activation response
Authors: Lindsay Angus , Othman Mohd Izani , Prebble Hannah , Davies Sian , Gieseg Steven P. 
Published: April 2016

New Findings
What is the central question of this study?
Acute and repetitive cryotherapy are routinely used to accelerate postexercise recovery, although the effect on resident immune cells and repetitive exposure has largely been unexplored and neglected.

What is the main finding and its importance?
Using blood‐derived mononuclear cells and semi‐professional mixed martial artists, we show that acute and repetitive cryotherapy reduces the in vitro and in vivo T‐cell and monocyte activation response whilst remaining independent of the physical performance of elite athletes.

We investigated the effect of repetitive cryotherapy on the in vitro (cold exposure) and in vivo (cold water immersion) activation of blood‐derived mononuclear cells following high‐intensity exercise. Single and repeated cold exposure (5°C) of a mixed cell culture (T cells and monocytes) was investigated using in vitro tissue culture experimentation for total neopterin production (neopterin plus 7,8‐dihydroneopterin). Fourteen elite mixed martial art fighters were also randomly assigned to either a cold water immersion (15 min at 10°C) or passive recovery protocol, which they completed three times per week during a 6 week training camp. Urine was collected and analysed for neopterin and total neopterin three times per week, and perceived soreness, fatigue, physical performance (broad jump, push‐ups and pull‐ups) and training performance were also assessed. Single and repetitive cold exposure significantly (P < 0.001) reduced total neopterin production from the mixed cell culture, whereas cold water immersion significantly (P < 0.05) attenuated urinary neopterin and total neopterin during the training camp without having any effect on physical performance parameters. Soreness and fatigue showed little variation between the groups, whereas training session performance was significantly (P < 0.05) elevated in the cold water immersion group. The data suggest that acute and repetitive cryotherapy attenuates in vitro T‐cell and monocyte activation. This may explain the disparity in in vivo neopterin and total neopterin between cold water immersion and passive recovery following repetitive exposure during a high‐intensity physical impact sport that remains independent of physical performance.