bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversing Immunosenescence with Senolytics to Enhance Tumor Immunotherapy
Authors: Liu Niu , Wu Jiaying , Deng Enze , Zhong Jianglong , Wei Bin , Cai Tingting , Duan Xiaohui , Fu Sha , Osei-Hwedieh David O. , Sha Ou , Chen Yunsheng , Lv Xiaobin , Zhu Yingying , Zhang Lizao , Lin Hsinyu , Li Qunxing , Lu Peichia , Miao Jiahao , Yamada Teppei , Cai Lei , Du Hongwei , Baca Sylvan C. , Huang Qingpei , Ferrone Soldano , Wang Xinhui , Xu Fang , Fan Xiaoying , Fan Song 
Published: October 2024

AbstractRecent advancements in cancer immunotherapy have improved patient outcomes, yet responses to immunotherapy remain moderate. We conducted a Phase II clinical trial (NCT04718415) involving 51 cancer patients undergoing neoadjuvant chemoimmunotherapy and applied single-cell RNA and T/BCR sequencing on tumor and blood samples to elucidate the immune cell perturbations. Our findings associate poor response with reduced levels of CCR7+CD4 Naïve T cells and CD27+Memory B cells, as well as higher expression of immunosenescence-related genes in T and B cell subsets. Using naturally aged andErcc1+/-transgenic aging mouse models, we found that senolytics enhance the therapeutic efficacy of immunotherapy in multiple solid tumors by mitigating tumor immunosenescence. Notably, we launched a Phase II clinical trial, COIS-01 (NCT05724329), which pioneers the combination of senolytics with anti-PD-1 therapy. The clinical results demonstrate that this therapeutic strategy is associated with a favorable safety profile and therapeutic efficacy, significantly mitigating adverse effects and alleviating immunosenescence. These findings underscore the pivotal role of immunosenescence characteristics in influencing the effectiveness of immunotherapy and suggest a promising therapeutic efficacy along with a beneficial safety assessment for the combination of senolytics with anti-PD-1 therapy.
A novel prediction model for immunotherapy induced pneumonitis prediction based on Chest CT and electronic health record
Authors: Lyu Qing , Yuan Hongyu , Lin Zhen , Ponnatapura Janardhana , Whitlow Christopher T 
Published: October 2024

AbstractImmune checkpoint inhibitors (ICIs) have been extensively used for the treatment of non-small cell lung cancer patients in recent years, providing a significant survival benefit. However, a major drawback of ICIs-related immunotherapy is the risk of developing post-surgical pneumonitis. In this study, we propose a deep learning-embedded, multi-modality prediction approach to assess whether patients will develop ICI-pneumonitis after receiving ICIs-based immunotherapy. This approach utilizes multi-modal data, including clinical data and pre-treatment lung screening computed tomography (CT) images. We extracted three types of features: 1) deep learning features from CT scans using a pretrained vision transformer, 2) radiomic features from CT scans using predefined radiomic algorithms, and 3) clinical features from patients’ clinical records. We then compared multiple machine learning algorithms for prediction based on these extracted features. Our results demonstrated a prediction accuracy of 0.823 and an area under the receiver operating characteristic curve of 0.895.
Structure of the turnip yellows virus particles. How is the readthrough domain exposed on the capsid surface?
Authors: Lai-Kee-Him Joséphine , Trapani Stefano , Boissinot Sylvaine , Reinbold Catherine , Fallet Chloé , Ancelin Aurélie , Lecorre François , Hoh François , Ziegler-Graff Véronique , Brault Véronique , Bron Patrick 
Published: October 2024

AbstractTurnip yellows virus (TuYV) is a plant virus infecting important crops such as oilseed rape. TuYV is phloem-restricted and transmitted by aphids. The capsid contains two subunit types: the major capsid protein (CP) and a minor component (RTP*) which arises from the C-terminal cleavage of a readthrough product (RTP). RTP* contains the CP sequence fused with a structured domain (denotedNRTD) which is a key determinant of virus transmission. Though both CP and RTP* are involved in virus movement and aphid transmission, how RTP* is incorporated into the capsid is poorly understood. We present here the structural characterisation (by immunogold labelling and 3D cryo-EM) of the wild-type TuYV and a mutant whose capsid contains the CP only. We show that incorporation of RTP* does not impair the capsid structure, and theNRTD does not adopt well-defined positions at the capsid surface. The number of incorporated RTP*s suggests a random insertion.
Most L1CAM is not associated with extracellular vesicles in human biofluids and iPSC–derived neurons
Authors: Kadam Vaibhavi , Wacker Madeleine , Oeckl Patrick , Korneck Milena , Dannenmann Benjamin , Skokowa Julia , Hauser Stefan , Otto Markus , Synofzik Matthis , Mengel David 
Published: October 2024

AbstractTransmembrane L1 cell adhesion molecule (L1CAM) is widely used as a marker to enrich for neuron-derived extracellular vesicles (EVs), especially in plasma. However, this approach lacks sufficient robust validation. This study aimed to assess whether human biofluids are indeed enriched for EVs, particularly neuron-derived EVs, by L1CAM immunoaffinity, utilizing multiple sources (plasma, CSF, conditioned media from iPSC-derived neurons [iNCM]) and different methods (mass spectrometry [MS], nanoparticle tracking analysis [NTA]).Following a systematic multi-step validation approach, we confirmed isolation of generic EV populations using size-exclusion chromatography (SEC) and polymer-aided precipitation (PPT) – two most commonly applied EV isolation methods – from all sources. Neurofilament light (NfL) was detected in both CSF and blood-derived EVs, indicating their neuronal origin. However, L1CAM immunoprecipitation did not yield enrichment of L1CAM in EV fractions. Instead, it was predominantly found in its free-floating form. Additionally, MS-based proteomic analysis of CSF-derived EVs also did not show L1CAM enrichment.Our study validates EV isolation from diverse biofluid sources by several isolation approaches and confirms that some EV subpopulations in human biofluids are of neuronal origin. Thorough testing across multiple sources by different orthogonal methods, however, does not support L1CAM as a marker to reliably enrich for a specific subpopulation of EVs, particularly of neuronal origin.
Likelihood analysis of the newly observed
f0(2020)
,
f0(2330)
, and
f0(2470)
in
J/ψ→γη′η′
as high-lying unflavored scalar mesons
Authors: Liu Cheng-Xi , Wang Li-Ming , Li Ting-Yan , Liu Xiang 
Published: October 2024

Inspired by the newly observed three scalar states f0(2020), f0(2330), and f0(2470) by the BESIII collaboration in J/ψ→γη′η′, we carried out the study of spectroscopic behavior of these high-lying unflavored scalar mesonic states. In this work, using the phenomenological description of radial (n,M2) trajectory and the quark pair creation model, we discussed the assignments of the f0(2020), f0(2330), and f0(2470) associated with the f0(2200) as the isoscalar high-lying scalar mesonic states and predicted the spectroscopic properties of their high-lying partners. The present study may provide valuable information for the construction of the scalar meson family.

Published by the American Physical Society
2024
Factors influencing consumers' purchase behavior toward indigenous chicken: insights from a cognitive affect behavior model
Authors: Abbasi Iffat Abbas , Shamim Amjad , Ashari Hasbullah 
Published: October 2024

PurposeThis study addresses a critical gap in understanding consumer behavior toward indigenous chicken, investigating the interaction between cognitive factors and purchase decisions. The current research offers a valuable contribution to the field of sustainable food marketing by shedding light on these dynamics.Design/methodology/approachThe research employed a quantitative survey method to gather data from consumers of indigenous chicken in Malaysia and analyzed it using structural equation modeling.FindingsHealth and price consciousness, along with effort expectancy, significantly influence consumer attitudes toward indigenous chicken. However, environmental consciousness and availability do not directly impact attitude. Similarly, attitude mediates the relationship between health consciousness, price consciousness, effort expectancy and purchase behavior, while attitude does not mediate the relationship between environmental consciousness, availability and purchase behavior of indigenous chicken.Originality/valueThis study is one of the pioneering works to apply the cognitive affect behavior (CAB) model to examine the factors influencing consumer attitudes and purchase behavior toward indigenous chicken. It investigates how constructs such as health consciousness, environmental consciousness, price consciousness, effort expectancy and availability affect these attitudes and behaviors, offering novel insights into the purchase intentions of younger and educated individuals.
Winners and losers in Africa: a longitudinal examination of market-share gains by advanced and emerging market multinationals versus local firms
Authors: Khan Huda , Ozkan Kubilay S.L. , Cavusgil Erin 
Published: October 2024

Purpose
Market share gain is one of the key objectives for all firms for seeking growth. It is also a fundamental aspect of competitive rivalry. The extant review of the literature points to a gap among market share performances of emerging market multinationals (EMNEs) firms, advanced economy multinationals (AMNEs) and local firms. The purpose of this study is to delineate and contrast the market share performance of EMNEs, AMNEs and local firms in Africa.

Design/methodology/approach
The study used available longitudinal data (2013–2022) of six industries across four African countries from Euromonitor Passport, a rich, proprietary database.

Findings
Applying contingency theory, the study shows that, over time, there is no clear-cut winner in all markets and industries. Rather, market share gain is contingent on country and industry settings in Africa. Empirical analysis demonstrates that high-tech EMNE firms operating in Africa will exceed those of high-tech AMNEs and local firms. The findings also show that local firms generally performed better during the pandemic.

Originality/value
As Africa is a region of interest for scholars and practitioners, critical international business (IB) research contributions in Africa have predominantly focused on foreign investments from a particular nation. The present study enriches the literature by comparing the market share performance of AMNEs, EMNEs and local firms in this important region – during and prepandemic. The study offers theoretical and managerial implications for understanding the long-term performance of these three types of firms.
Design process of ruins of the Great East Japan Earthquake: Nakahama Elementary School
Authors: Motoe Masashige 
Published: October 2024

PurposeThis study clarifies the design process for preserving and opening Nakahama Elementary School, damaged in the 2011 Great East Japan Earthquake, to the public in 2020 as a museum facility that allows visitors to view the interior and learn about what was experienced here on March 11, 2011.Design/methodology/approachThere are several unique aspects of the processes for preserving Nakahama Elementary School and the design for reopening it as a disaster ruins and museum facility. This paper explains the significances of the processes and results and provides detailed insights from involvement in the design process and includes a detailed chronology of the process. It also deals with important questions raised regarding the preservation of disaster remains and what lessons should be conveyed to visitors based on the reality of the disaster experience on this site.FindingsOver 10 years, storytelling, committee recommendations, a master plan, regulations and renovation design were developed through a layered, step-by-step process to determine the meaning of the ruins. Rather than emphasizing earthquake threats or reconstruction achievements, it was important to understand the latent meaning of the site through stakeholder discussions, capture details of the disaster experience for visitors to relive and express the region’s unique disaster culture.Originality/valueThis original case study comprehensively describes administrative procedures and community relationships in preserving and utilizing disaster remains. As the author served on the initial study committee and continued to be responsible for the basic planning, architectural renovation design, exhibition planning and actual production of the guidebooks, the paper presents rare insights from the real experience of practical involvement in the planning and design process of the preservation of this heritage site.
The dark side of stock repurchases: do they affect marketing capabilities?
Authors: Wen Yuan , John-Mariadoss Babu , Umesh U.N. , Sa Vinhas Alberto , Kuzmich Daniel 
Published: October 2024

Purpose
This study aims to investigate the effect of stock repurchase – firms buying back their own stocks – on firm performance, focusing specifically on the role of marketing capability. The authors also investigate the moderating influence of competitive intensity on this effect. This research sheds light on how marketing capability explains the negative effect of stock repurchase on firm performance, and how this effect varies in different competitive intensity environments.

Design/methodology/approach
The authors test their hypotheses using US firm-level longitudinal data collected from a sample set of firms obtained from the Compustat database for the 1989–2015 period. The authors specify a panel data regression model to test the hypotheses.

Findings
The authors find that adoption of stock repurchase ultimately results in a decrease in firm performance, through a decrease in marketing capability. The authors also find that the indirect effect of stock repurchase on firm performance is moderated by firm competitive intensity, such that at higher levels of competitive intensity, the negative relationship between stock repurchase and marketing capability will become amplified and at lower levels of competitive intensity, the negative relationship between stock repurchase and marketing capability will get attenuated.

Research limitations/implications
This study indicates that the risk from stock repurchase is the diversion of funds from other beneficial activities such as marketing budgets, leading to lowered marketing capability.

Practical implications
This study's results will help managers improve their understanding of the dark side of the stock repurchase strategy and help take corrective action.

Originality/value
The present study empirically tests the effects of stock repurchase on marketing capability and firm performance.
What drives viewers’ engagement in travel live streaming: a mixed-methods study from perceived value perspective
Authors: Chen Yuangao , Tao Liyan , Zheng Shuang , Yang Shuiqing , Li Fujun 
Published: October 2024

Purpose
The purpose of this study is to explore the factors influencing viewers’ engagement intention in travel live streaming (TLS) from a perceived value perspective.

Design/methodology/approach
This study used a mixed-methods approach. In Study 1, 48 semistructured interviews were analyzed based on grounded theory and perceived value theory, and a research framework was established to investigate the impact of viewers’ engagement intentions in TLS. In Study 2, partial least squares structural equation modeling (PLS-SEM) was used to empirically validate survey data from 255 TLS viewers.

Findings
Through an analysis of the interview content, it was found that the expertise and interaction of the live streamer in TLS as well as the immersion, aesthetics and novelty of the live streaming scene are key influencing factors that affect the engagement of TLS viewers. This finding was confirmed through empirical research.

Practical implications
This research provides practical suggestions for live streamers, TLS platforms and local government to increase viewer engagement. Specifically, it provides methods and directions for the individual improvement of live streamers, further promotes the development and construction of the platform and underscores the importance of government initiatives in policy support and regulatory framework development.

Originality/value
This study focuses on the less-researched field of TLS. Using a mixed-methods approach combining interviews and PLS-SEM, this study explores the key factors that affect the engagement of TLS viewers based on the characteristics of live streamers and live streaming scenes.
Beyond teaching: the extended role of informal entrepreneurship education and training in challenging contexts
Authors: Akullo Grace , Aracil Elisa , Mwaura Samuel , McMillan Carolyn 
Published: October 2024

PurposeWe seek to understand how informal entrepreneurship education and training (EET) processes support marginalised women in challenging institutional contexts into gainful participation in entrepreneurial activities, facilitating empowerment and emancipation.Design/methodology/approachThe study employs an inductive qualitative approach drawing on in-depth individual interviews, a focus group and observation of how female informal EET educators facilitate hands-on EET to marginalised female entrepreneurs in Uganda.FindingsWe specify a range of novel complementary practices that informal EET educators undertake during the main instructional EET stage and present the wraparound purposive work, both pre-and-post the instructional stage, they enact to support female empowerment processes for their disadvantaged learners. We then propose a grounded model capturing practices enacted by EET practitioners that illuminates ways in which informal EET can contribute to processes of empowerment and emancipation.Originality/valueOur contributions are twofold. First, we conceptualise EET educators as institutional entrepreneurs undertaking institutional work beyond core teaching. Second, we specify a range of novel complementary practices they undertake before, during and after the conventional instructional part. This illuminates how EET can contribute to processes of empowerment and emancipation. Drawing on data from a unique institutional context, we illuminate novel practices enacted by informal EET educators thereby extending both the pedagogy and the realm of entrepreneurship education with implications for grander empowerment and emancipatory outcomes beyond the development of entrepreneurial competencies.
Cognition, horizon and practice: formation of the nonsynchronism in theoretical research of information science
Authors: Wang Fang , Zhu Hongzhi 
Published: October 2024

Purpose The nonsynchronism in theoretical research of information science (IS) is an interesting phenomenon that has not been sufficiently examined. This study is to reveal the mechanism of its formation from a microscopic perspective.Design/methodology/approach A qualitative research approach was adopted and 22 professors from different IS fields were interviewed. The data were analyzed with a six-step thematic analysis method.Findings The nonsynchronism in IS theoretical research is reflected in three dimensions. Theory cognition and theory practice shape each other under the constraint of theory horizon. Researchers with similar theory cognition and practice form a theoretical generation. The inter-generational gap may exist among IS researchers in different research areas, at different ages, or located in different countries or regions.Research limitations/implications This study reveals the formation mechanism of the nonsynchronism in IS theoretical research from a microscopic perspective of individual researcher’s theory using practice and offers new insights into the dynamics of the structural evolution of IS theoretical knowledge.Practical implicationsThe results of this study can help to promote internal or external communication in IS and enhance theoretical education for doctoral students.Originality/valueThis study identifies and theoretically defines a few core themes, theory horizon, theory cognition, theory practice and theoretical generation, and reveals their relationships. On this basis, a conceptual model of nonsynchronism in theoretical research is developed.
Improving community vitality: spiritually informed entrepreneurial actions
Authors: Dissanayake Srinath , Pavlovich Kathryn , Kovács Gábor 
Published: October 2024

Purpose
The purpose of this paper is to depict how entrepreneurs improve community vitality in the economic, social and environmental dimensions. The paper joins the conversation of business spirituality as the study participants were Sri Lankan Buddhist entrepreneurs from the emerging venture context (i.e. from enterprises which are less than 1–10 years old). The aim of the paper is to introduce spiritually informed entrepreneurial actions, thus contributing to a better understanding of entrepreneurial impact on communities.

Design/methodology/approach
The paper involves a qualitative, interpretivist research design. Data was collected by conducting 28 semi-structured interviews with 18 Sri Lankan Buddhist entrepreneurs. Research participants were selected from diverse business sectors. The research applied inductive thematic analysis for structuring and interpreting data.

Findings
For Sri Lankan Buddhist entrepreneurs, improving community vitality is an essential altruistic goal of their business agenda. During the operations of their ventures, this altruistic goal is translated into altruistic actions that improve the economic, social and environmental vitalities of communities. Research findings highlight that in the case of Sri Lankan Buddhist entrepreneurs, altruistic actions are informed by compassion, which is a fundamental value in the Buddhist religion. Drawing on the findings, an integrated model of community vitality, which describes the role of compassion and the mechanisms of entrepreneurial actions in a Buddhist setting was developed inductively.

Originality/value
Studying entrepreneurial actions to focus on the motivations behind improving community vitality is a new research topic. The paper provides valuable knowledge on business spirituality regarding the compassionate motivations of Buddhist entrepreneurs. The integrated model of community vitality, which describes the mechanisms of entrepreneurial actions to improve community vitality in a Buddhist setting could be an essential compass not only to entrepreneurs but also research scholars in the field of business spirituality.