bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding leisure‐time physical activity: Voices of people with MS who have moderate‐to‐severe disability and their family caregivers
Authors: Fakolade Afolasade , Lamarre Julie , Latimer‐Cheung Amy , Parsons Trisha , Morrow Sarah A. , Finlayson Marcia 
Published: July 2017

AbstractBackgroundPhysical activity (PA) is beneficial for all people, yet people affected by multiple sclerosis (MS) find regular PA challenging. These people may include individuals with the disease who have moderate‐to‐severe disability and their family caregivers. For researchers and clinicians to effectively promote PA among caregiver/care‐recipient dyads with moderate‐to‐severe MS, a comprehensive understanding of the shared PA experiences of these dyads would be beneficial.ObjectiveWe explored shared experiences of caregiver/care‐recipient dyads affected by moderate‐to‐severe MS about PA and directions for intervention.MethodsSix focus groups with 23 people with moderate‐to‐severe MS and 12 family caregivers were conducted. Data were analysed using a constant comparative approach.ResultsThree major themes emerged as follows: (i) PA is a continuum, (ii) cycle of disengagement and (iii) cycle of adjustment. The first theme captured the dyads understanding that PA falls along a continuum ranging from highly structured to unstructured activities. Cycle of disengagement captured the experiences of dyads engaging in little or no PA. These dyads perceived internal and external issues as drivers of the cycle of disengagement, while availability of supportive programmes and services or people helped the dyads to break out of the cycle. When the cycle of disengagement was broken, the dyads described moving towards the cycle of adjustment, where they were able to learn skills and take action to incorporate PA into daily routines.ConclusionThis research highlights the need to adopt an integrative approach that acknowledges the caregiver/care‐recipient dyad with moderate‐to‐severe MS as a focus for PA intervention.
Mineral chemistry and petrogenesis of chromitites from theKhoy ophiolite complex,NorthwesternIran:Implications for aggregation of two ophiolites
Authors: Zaeimnia Fatemeh , Kananian Ali , Arai Shoji , Mirmohammadi Mirsaleh , Imamalipour Ali , Khedr Mohamed Zaki , Miura Makoto , Abbou‐Kebir Khadidja 
Published: July 2017

AbstractTheKhoy ophiolitic complex inNorthwestern Iran is a part of theTethyan ophiolite belt, and is divided into two sections: theEastern ophiolite inQeshlaq andKalavanes (Jurassic–Cretaceous) and theWestern ophiolite inBarajouk,Chuchak andHessar (LateCretaceous). Our chromitites can be clearly classified into two groups: high‐Al chromitites (Cr# = 0.38–0.44) from theEastern ophiolite, and high‐Cr chromitites (Cr# = 0.54–0.72) from theWestern ophiolite. The chromian spinels in high‐Al chromitite include primary mineral inclusions mainly asNa‐bearing diopside and pargasite with subordinate rutile and their formation was probably related to reaction between aMORB(mid‐ocean‐ridge basalt)‐like melt with depleted harzburgite, possibly in a back‐arc setting. Their host harzburgites contain clinopyroxene with higher contents ofAl2O3,Na2O,Cr2O3, andTiO2relative toWestern harzburgites and are possibly residue after moderate partial melting (~15 %) whereas the Western harzburgite is residue after high partial melting (~25 %). The chromian spinel in theWesternKhoy chromitites contains inclusions such as clinopyroxene, olivine and platinum group mineral‐bearing sulfides. TheseWestern chromitites were possibly formed at two stages during arc growth and are divided into the moderately high‐Cr# chromitites (Barajouk andHessar) and the high‐Cr# chromitites (ChuchakAandC). The former crystallized from island‐arc‐tholeiite (IAT) melts during reaction with the host depleted harzburgites, whereas the latter crystallized from boninitic melts (second stage melt) during reaction with highly depleted harzburgite in a supra‐subduction‐zone environment. Based on the mineral chemistry of chromian spinels, pyroxenes, and mineral inclusions, the chromitites and the host peridotites from theEastern andWesternKhoy ophiolites were formed in a back‐arc basin and arc‐related setting, respectively. TheKhoy ophiolitic complex is a tectonic aggregate of the two different ophiolites formed in two different tectonic settings at different ages.
Diagnostic and prognostic value of low percentage of glycosylated ferritin in acquired hemophagocytic lymphohistiocytosis: A single‐center study
Authors: Nabergoj M. , Marinova M. , Binotto G. , Brugnaro L. , Zaninotto M. , Plebani M. , Semenzato G. , Vianello F. 
Published: July 2017

AbstractIntroductionHemophagocytic lymphohistiocytosis (HLH) is an aggressive and life‐threatening syndrome characterized by an excessive immune activation. Glycosylated ferritin (GF) level has been proposed as highly specific of HLH.MethodsWe have studied 12 subjects with HLH according to the HLH‐04 trial criteria and 11 patients with a clinical and laboratoristic suspicion of HLH. The percentage of GF was measured by an in‐house assay.ResultsThe only biomarkers that were significantly different in the two groups were fraction of GF (P<.001) and the presence of hemophagocytosis in bone marrow (P=.006). Subjects with HLH had significantly lower percentage of GF than patients with other inflammatory conditions mimicking HLH. A fraction of GF ≤20% was strongly consistent with a diagnosis of HLH.ConclusionsFraction of GF is useful to identify subjects at high risk for early death and therefore in need of early treatment.
Classical, Critical and Constructive: Paul Hinlicky's Beloved Community
Authors: Peters Ted 
Published: July 2017

AbstractThis engagement with Paul Hinlicky's systematic theology, Beloved Community, provides both analysis of his text and constructive enhancement of the wider discussion of the Trinity. The term ‘Beloved Community’ is what Hinlicky calls the Trinity, an open Trinity that invites believers into the divine life. This book, like a springboard, encourages diving into the new trinitarianism inaugurated by the two Karls, Karl Barth and Karl Rahner. I place Hinlicky into this stream of thought and then raise the critical question: is this new trinitarianism conflictual or compatible with the classical theism we find in both Christianity and Islam?
“Back There We Had Nothing to Eat”: The Case of Transnational Food Insecurity
Authors: Carney Megan A. 
Published: July 2017

AbstractThis article discusses migrant food insecurity in the United States from the perspective of Mexican and Central American migrant women. Many describe migrating because they had nothing to eat in their countries of origin. Migration is thus framed as a necessary strategy for overcoming food insecurity. I argue that these women's perspectives are unique in the migration literature because food security comprises a gendered labour from which men are frequently spared. Unfortunately, food insecurity still prevails in these women's households in the US. Assuming a “double‐duty” workday of earning wages and overseeing care within households, these women experience the added burden of ensuring food security of households “back there.” Thus, I argue that the food practices of Mexican and Central American migrant women provide a unique lens through which to understand the increased feminization of transnational migration from Latin America to other regions of the world.
Optimal portfolio trading subject to stochastic dominance constraints under second‐order autoregressive price dynamics
Authors: Singh Arti , Dharmaraja Selvamuthu 
Published: July 2017

AbstractThis paper studies the optimal portfolio trading problem under the generalized second‐order autoregressive execution price model. The problem of minimizing expected execution cost under the proposed price model is formulated as a quadratic programming (QP) problem. For a risk‐averse trader, problem formulation under the second‐order stochastic dominance constraints results in a quadratically constrained QP problem. Under some conditions on the execution price model, it is proved that the portfolio trading problems for risk‐neutral and risk‐averse traders become convex programming problems, which have many theoretical and computational advantages over the general class of optimization problems. Extensive numerical illustrations are provided, which render the practical significance of the proposed execution price model and the portfolio trading problems.
A novel fabrication method for glass foams with small pore size and controllable pore structure
Authors: Huo Wenlong , Yan Shu , Wu Jia‐Min , Liu Jingjing , Chen Yugu , Qu Yanan , Tang Xinyue , Yang Jinlong 
Published: July 2017

AbstractIn this paper, a novel fabrication method for glass foams has been introduced based on colloidal suspension foaming method using waste glass as starting materials. It is demonstrated for the first time that foam stabilization via in‐situ hydrophobization of waste glass particles is possible. The fabrication conditions for stable glass particle‐stabilized foams are optimized by investigating the influences of pH value, concentration of propyl gallate and ball milling time, respectively. It is demonstrated that this is a versatile method for fabrication of stable foamed glass suspension and final glass foams with small pore size of dozens of microns, which is much smaller than that of most glass foams in previous literatures. This novel method enables both closed pore structure and open pore structure simply by tailoring solid loading of glass suspension. A “sieve‐like” hierarchical pore structure can be achieved by adjusting sintering temperature. The glass foams with controllable structure could be applied in thermal insulation fields for closed pores, and in catalyst loading, filtration, and separation fields for open pores and hierarchical pore structure.
Blood pressure–lowering efficacy of indapamide SR/amlodipine combination in older patients with hypertension: A post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria)
Authors: Hanon Olivier , Caillard Laure , Chaussade Edouard , Hernandorena Intza , Boully Clemence 
Published: July 2017

To examine the antihypertensive efficacy and safety of indapamide sustained‐release (SR)/amlodipine compared with enalapril/amlodipine in patients 65 years and older with uncontrolled blood pressure (BP) on monotherapy, a post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria) was conducted. NESTOR randomized 570 patients (n=197, aged ≥65 years) with hypertension (systolic BP 140–180/diastolic BP <110 mm Hg) to indapamide SR 1.5 mg or enalapril 10 mg. If target BP (<140/85 mm Hg) was not achieved at 6 weeks, amlodipine 5 mg was added with uptitration to 10 mg if required. A total of 107 patients aged 65 years and older received dual therapy (53 indapamide SR/amlodipine and 54 enalapril/amlodipine). Amlodipine uptitration occurred in 22 and 24 patients, respectively. At 52 weeks, mean systolic BP (±SE) reduction was significantly greater with indapamide SR/amlodipine vs enalapril/amlodipine 6.2±2.7 mm Hg (P=.02). Indapamide SR/amlodipine was also associated with a greater BP response rate (88% vs 75%, respectively). Both regimens were well tolerated. Indapamide SR/amlodipine may be more effective than enalapril/amlodipine for lowering systolic BP in patients with hypertension aged 65 years and older.
Rho‐associated protein kinases as therapeutic targets for both vascular and parenchymal pathologies in Alzheimer's disease
Authors: Lai Aaron Y. , McLaurin JoAnne 
Published: July 2017

AbstractThe causes of late‐onset Alzheimer's disease are unclear and likely multifactorial. Rho‐associated protein kinases (ROCKs) are ubiquitously expressed signaling messengers that mediate a wide array of cellular processes. Interestingly, they play an important role in several vascular and brain pathologies implicated in Alzheimer's etiology, including hypertension, hypercholesterolemia, blood–brain barrier disruption, oxidative stress, deposition of vascular and parenchymal amyloid‐beta peptides, tau hyperphosphorylation, and cognitive decline. The current review summarizes the functions of ROCKs with respect to the various risk factors and pathologies on both sides of the blood–brain barrier and present support for targeting ROCK signaling as a multifactorial and multi‐effect approach for the prevention and amelioration of late‐onset Alzheimer's disease.
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This article is part of the Special Issue “Vascular Dementia”.
In vitro evaluation of chitosan‐coated liposome containing both coenzyme Q10 and alpha‐lipoic acid: Cytotoxicity, antioxidant activity, and antimicrobial activity
Authors: Zhao Guodong , Hu Caibiao , Xue Ying 
Published: July 2017

SummaryBackgroundChitosan‐coated liposome containing both coenzyme Q10 and alpha‐lipoic acid (CCAL) was a novel multifunctional nano delivery system exhibited long‐term stability at room temperature and high encapsulation efficiency. Which containing two kinds of antioxidants (coenzyme Q10 and alpha‐lipoic acid) and two antibacterial agents (chitosan and alpha‐lipoic acid). However, the further biocompatibility, such as cytotoxicity and antioxidant activity, and antimicrobial activity of CCAL, has not been systematically evaluated.ObjectivesThis study aims to evaluate the cytotoxicity, antioxidant activity and antimicrobial activity of CCAL.MethodsThis article evaluated the in vitro cytotoxicity and antioxidant activity of CCAL by CCK8 assay, and antimicrobial activity on Staphylococcus aureus and Escherichia coli was investigated.ResultsFor antioxidant activity study, CCAL displayed significant antioxidant effect when compared with control group (P<.01). Finally, CCAL also exhibited antimicrobial activity, and CCAL showed stronger bactericidal effect with Gram‐positive bacteria than Gram‐negative bacteria.ConclusionsCCAL could be a potential antioxidant delivery system for cosmetics or pharmaceuticals without cytotoxicity and artificial preservatives free.
Safety of orbital atherectomy in patients with left ventricular systolic dysfunction
Authors: Shlofmitz Evan , Meraj Perwaiz , Jauhar Rajiv , Sethi Sanjum S. , Shlofmitz Richard A. , Lee Michael S. 
Published: July 2017

ObjectivesWe evaluated the angiographic and clinical outcomes in patients with severely calcified lesions and systolic dysfunction who underwent orbital atherectomy (OA). We hypothesized that OA would provide similar outcomes in patients with systolic dysfunction compared with patients with preserved systolic function.BackgroundSystolic dysfunction is associated with an increased risk of adverse clinical events after percutaneous coronary intervention (PCI). The effects of OA in patients with systolic dysfunction are unknown.MethodsOur analysis retrospectively analyzed 438 patients (n = 69 with EF ≤ 40%) who underwent OA. The primary endpoint was the rate of major adverse cardiac and cerebrovascular events (MACCE) at 30 days.ResultsThere were no significant differences between patients with preserved versus reduced systolic function in terms of dissections (0.9% vs. 1.6%, P = 0.51), perforation (0.3% vs. 3.2%, P = 0.07), or no reflow (0.3% vs. 3.2%, P = 0.07). Patients with systolic dysfunction had higher rates of the composite of 30‐day MACCE (1.1% vs. 8.7%, P = 0.002) and the individual end points of death (0.3% vs. 7.2%, P < 0.001), and myocardial infarction (0.5% vs. 4.3%, P = 0.03). The rates of target vessel revascularization (0% vs. 0%, P = 1), stroke (0.3% vs. 0%, P > 0.9), and stent thrombosis (0.8% vs. 1.4%, P = 0.5) were low in both groups and did not differ.ConclusionPlaque modification with OA was safe and well tolerated in patients with systolic dysfunction. In this high‐risk cohort, adverse clinical outcomes occurred more frequently than in a lower risk population.
Solubility and molecular interactions of ferulic acid in various (isopropanol + water) mixtures
Authors: Haq Nazrul , Siddiqui Nasir A , Shakeel Faiyaz 
Published: July 2017

Abstract

Objective
The solubility of an herbal compound ferulic acid (FA) in various (isopropanol (IPA) + water) mixtures was measured and correlated at temperatures ‘T = 298.2 K to 318.2 K’ and pressure ‘p = 0.1 MPa’.

Methods
The experimental solubilities of FA in mole fraction were determined using a static equilibrium method and correlated with ‘Apelblat, Van't Hoff, Yalkowsky and Jouyban–Acree models’.

Key findings
The maximum mole fraction solubilities of FA were obtained in neat IPA (2.58 × 10−2 at T = 318.2 K) followed by minimum in neat water (4.87 × 10−5 at T = 298.2 K). The activity coefficients of FA in various (IPA + water) mixtures were determined to evaluate the molecular interactions between FA and co solvent mixtures. Strong molecular interactions were seen between FA and neat IPA in comparison with FA and neat water. ‘Apparent thermodynamic analysis’ indicated an ‘endothermic and entropy-driven dissolution’ of FA in all (IPA + water) mixtures evaluated.

Conclusions
Isopropanol was investigated as a good cosolvent in the solubility enhancement of FA in water; therefore, it could be used as solubilizer in solubility enhancement and formulation development of FA.
Collection of voucher specimens for bat research: conservation, ethical implications, reduction, and alternatives
Authors: Russo Danilo , Ancillotto Leonardo , Hughes Alice C. , Galimberti Andrea , Mori Emiliano 
Published: July 2017

AbstractVoucher specimens have played a fundamental role in biology, but ethical and conservation concerns have been raised over unnecessary collection of organisms. From 1996 to 2017, 222 studies mentioned the collection of 7482 bats of 376 species, mostly from South America and Asia (India, China, and South‐East Asia). Researchers mostly aimed to compile checklists or establish geographic ranges. Strong ethical reasons exist to avoid unnecessary collection, and suitable alternatives should be sought; for example, collecting voucher specimens for retrospective taxonomic confirmation can be replaced with molecular methods. We provide information on alternative methods and when to use them to avoid harming fragile populations of bats.
Narrative and Metaphysical Ambition: On Being “in Christ”
Authors: Lett Jonathan 
Published: July 2017

AbstractThis article addresses some of the confusion regarding the role of metaphysical claims in narrative theology. Proponents and critics of narrative theology alike wonder at the ambiguous place of metaphysical speech about God as an objective reality. This essay enters the conversation through the side door of soteriology. Rather than focusing on the relationship between narrative and metaphysics or narrative and analogy or narrative and first‐order theological claims, I examine what sort of metaphysical statements are required to make the Christian claim that human beings are “in Christ” intelligible as a soteriological reality. I argue that the Christian grammar itself assumes a Christology with a certain kind of metaphysical ambition without which Christianity lapses into incoherence. To make this case, I show that David Kelsey's “narrative identity” Christology in Eccentric Existence lacks the metaphysical statements necessary to uphold his conviction that human beings are “in Christ.” A comparison with T. F. Torrance and the Book of Hebrews reveals that when narrative circumvents metaphysical statements about the incarnate Son, soteriological claims lack coherence and the biblical narrative itself is distorted by a false metaphysic. Thus, metaphysical claims internal to the narrative of Jesus are necessary to tell the story of God faithfully. In this way, narrative is the expression of a theological metaphysics.
Biology of SLAC1‐type anion channels – from nutrient uptake to stomatal closure
Authors: Hedrich Rainer , Geiger Dietmar 
Published: July 2017

SummaryStomatal guard cells control leaf CO2 intake and concomitant water loss to the atmosphere. When photosynthetic CO2 assimilation is limited and the ratio of CO2 intake to transpiration becomes suboptimal, guard cells, sensing the rise in CO2 concentration in the substomatal cavity, deflate and the stomata close. Screens for mutants that do not close in response to experimentally imposed high CO2 atmospheres identified the guard cell‐expressed Slowly activating anion channel, SLAC1, as the key player in the regulation of stomatal closure. SLAC1 evolved, though, before the emergence of guard cells. In Arabidopsis, SLAC1 is the founder member of a family of anion channels, which comprises four homologues. SLAC1 and SLAH3 mediate chloride and nitrate transport in guard cells, while SLAH1, SLAH2 and SLAH3 are engaged in root nitrate and chloride acquisition, and anion translocation to the shoot. The signal transduction pathways involved in CO2, water stress and nutrient‐sensing activate SLAC/SLAH via distinct protein kinase/phosphatase pairs. In this review, we discuss the role that SLAC/SLAH channels play in guard cell closure, on the one hand, and in the root–shoot continuum on the other, along with the molecular basis of the channels’ anion selectivity and gating.

Contents

Summary
46

I.
Introduction
46

II.
SLAC1 evolved before stomata
47

III.
Multisensory guard cells integrate abiotic and biotic signals (Fig. 3)
50

IV.
Anion channels in shoot and root
53

V.
Structural basis for selectivity and gating
56

VI.
Future opportunities
57

Accession numbers
58

Acknowledgements
58

References
58
CATALASE2 functions for seedling postgerminative growth by scavenging H2O2 and stimulating ACX2/3 activity in Arabidopsis
Authors: Liu Wen‐Cheng , Han Tong‐Tong , Yuan Hong‐Mei , Yu Zhen‐Dong , Zhang Lin‐Yu , Zhang Bing‐Lei , Zhai Shuang , Zheng Si‐Qiu , Lu Ying‐Tang 
Published: July 2017

AbstractIncreased fatty acid β‐oxidation is essential for early postgerminative growth in seedlings, but high levels of H2O2 produced by β‐oxidation can induce oxidative stress. Whether and how catalase (CAT) functions in fine‐tuning H2O2 homeostasis during seedling growth remain unclear. Here, we report that CAT2 functions in early seedling growth. Compared to the wild type, the cat2‐1 mutant, with elevated H2O2 levels, exhibited reduced root elongation on sucrose (Suc)‐free medium, mimicking soils without exogenous sugar supply. Treatment with the H2O2 scavenger potassium iodide rescued the mutant phenotype of cat2‐1. In contrast to the wild type, the cat2‐1 mutant was insensitive to the CAT inhibitor 3‐amino‐1,2,4‐triazole in terms of root elongation when grown on Suc‐free medium, suggesting that CAT2 modulates early seedling growth by altering H2O2 accumulation. Furthermore, like cat2‐1, the acyl‐CoA oxidase (ACX) double mutant acx2‐1 acx3‐6 showed repressed root elongation, suggesting that CAT2 functions in early seedling growth by regulating ACX activity, as this activity was inhibited in cat2‐1. Indeed, decreased ACX activity and short root of cat2‐1 seedlings grown on Suc‐free medium were rescued by overexpressing ACX3. Together, these findings suggest that CAT2 functions in early seedling growth by scavenging H2O2 and stimulating ACX2/3 activity.