bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hit Identification of a Novel Dual Binder for h‐telo/c‐myc G‐Quadruplex by a Combination of Pharmacophore Structure‐Based Virtual Screening and Docking Refinement
Authors: Rocca Roberta , Costa Giosuè , Artese Anna , Parrotta Lucia , Ortuso Francesco , Maccioni Elias , Pinato Odra , Greco Maria Laura , Sissi Claudia , Alcaro Stefano , Distinto Simona , Moraca Federica 
Published: March 2016

AbstractIt is well known that G‐quadruplexes are targets of great interest for their roles in crucial biological processes, such as aging and cancer. Hence, a promising strategy for anticancer drug therapy is the stabilization of these structures by small molecules. We report a high‐throughput in silico screening of commercial libraries from several different vendors by means of a combined structure‐based pharmacophore model approach followed by docking simulations. The compounds selected by the virtual screening procedure were then tested for their ability to interact with human telomeric G‐quadruplex folding by circular dichroism, fluorescence spectroscopy, and fluorescence intercalator displacement. Our approach resulted in the identification of a 13‐[(dimethylamino)methyl]‐12‐hydroxy‐8H‐benzo[c]indolo[3,2,1‐ij][1,5]naphthyridin‐8‐one derivative as a novel promising stabilizer of G‐quadruplex structures within the human telomeric and the c‐myc promoter sequences.
Systematic approach for deriving feasible mappings of parallel algorithms to parallel computing platforms
Authors: Arkin Ethem , Tekinerdogan Bedir , İmre Kayhan M. 
Published: March 2016

SummaryThe need for high‐performance computing together with the increasing trend from single processor to parallel computer architectures has leveraged the adoption of parallel computing. To benefit from parallel computing power, usually parallel algorithms are defined that can be mapped and executed on parallel computing platforms. In general, different alternative mappings can be defined each with different performance. For small computing platforms with a limited number of processing nodes, the mapping process can be carried out manually. However, for large‐scale parallel computing platforms in which hundreds of thousands of processing nodes are applied, the number of possible mapping alternatives increases dramatically, and the mapping process becomes intractable for the human engineer. To assist the parallel computing engineer, we provide a systematic approach to derive feasible mapping alternatives of parallel algorithms to parallel computing platforms. The approach includes activities for modeling the parallel algorithm and parallel computing platform, generation of feasible mapping alternatives, generation of the deployment code, and finally the deployment of the generated code to the nodes. We evaluate our approach for deriving feasible mapping alternatives for four well‐known parallel algorithms. The evaluation is based on both simulations and real executions of the generated mapping alternatives. Copyright © 2016 John Wiley & Sons, Ltd.
Survival rate of teeth with periodontally hopeless prognosis after therapies with intentional replantation and perioprosthetic procedures ‐ a study of case series for 5–12 years
Authors: Hou Guey‐Lin , Hou Lein‐Tuan , Weisgold Arnold 
Published: March 2016

AbstractThe purpose of the present study was to evaluate the longitudinal survival rate of the treatment of teeth affected with periodontally hopeless prognosis and secondary occlusal traumatism (SOT) using intentional replantation (IR) and periodontal prosthesis. We collected data from 17 individuals who received IR and participated in the study during 1995 to 2014. Of the 17 teeth affected by periodontally extreme conditions with deep angular bone defects, severe alveolar bone loss extending to or beyond the apex, and SOT, was recognized as having hopeless prognosis. Those teeth were treated sequentially using procedures that included basic periodontal therapy, therapeutic provisional prosthesis, IR, fixed dental prosthesis, crown and sleeve‐coping telescopic dentures (CSCTDs), or fixed prosthesis and CSCTD combined. Longitudinal assessments of clinical parameters and radiographic bone change before and after IR were evaluated. Clinical results showed that the overall cumulative survival rate of assayed teeth after IR therapy (5–12 years) was 88.2%. The mean (±SD) estimated radiographic alveolar bone loss was 12.7 ± 2.1 mm (88.5% ± 13.3%) of the root length, initially, and estimated radiographic alveolar bone gain was 4.0 ± 2.2 mm ultimately, in 17 replanted teeth with SOT. Only one tooth (5.9%) exhibited root resorption. Ankylosis was not observed during the study. Periapical radiographs demonstrated that satisfactory periodontal healing of lamina dura and bone fills occurred in all replanted teeth with SOT. Generally, tooth mobility and SOT were significantly improved after therapy. Most treated teeth functioned well and remained stable clinically throughout the periods of study. The present study documented a promising outcome for autogenous IR and periprosthetic therapy of 17 periodontally hopeless teeth for 5–12 years. The present study revealed good bone gain and elimination of SOT and prominent occlusal function. We concluded that the application of IR, minocycline‐HCL and periodontal prosthetic procedures later elevated the prognosis of these otherwise hopeless teeth with SOT, which are valuable options for retaining teeth with periodontally extreme situations.
Prevalence of furcation‐involved molars in a Swedish adult population. A radiographic epidemiological study
Authors: Najim Uday , Slotte Christer , Norderyd Ola 
Published: March 2016

AbstractThe purpose of this study was to identify the prevalence of molars with furcation involvements grades II and III in adults participating in the Jönköping Oral Health Study 2003. The second aim was to study correlations between different variables and the presence of furcation involvement in these individuals. The present study was performed using bitewing and apical radiographs from 329 subjects. Furcations were considered healthy if the furcation was filled with bone up to the fornix. Two thousand fourteen molars fulfilled the inclusion criteria. The prevalence of molars with furcation involvements was 8.3%. Univariate analysis showed that plaque, age, and presence of periodontal pockets were significantly correlated with furcation‐involved molar/s (P ˂ 0.0001). Gingivitis and education were also significantly correlated to the presence of furcation involvement (P ˂ 0.006) and (P ≤ 0.01), respectively. Gender had no association with presence of involvements. Multivariate analysis showed that age and presence of periodontal pockets were significantly correlated with furcation involvement (P ˂ 0.0001). Smoking was also found to be associated with furcation involvement (P ˂ 0.04). The tooth most frequently and least likely displaying furcation involvement was the maxillary first molar and the mandibular second molar, respectively. Periodontal pockets, age, and smoking were risk indicators for furcation involvement.
A single‐stage LED streetlight driver with PFC and digital PWM dimming capability
Authors: Cheng Chun‐An , Chung Tsung‐Yuan 
Published: March 2016

SummaryThis paper proposes a single‐stage light‐emitting diode (LED) driver that offers power‐factor correction and digital pulse–width modulation (PWM) dimming capability for streetlight applications. The presented LED streetlight driver integrates an alternating current–direct current (AC–DC) converter with coupled inductors and a half‐bridge‐type LLC DC–DC resonant converter into a single‐stage circuit topology. The sub‐circuit of the AC–DC converter with coupled inductors is designed to be operated in discontinuous‐conduction mode for achieving input‐current shaping. Zero‐voltage switching of two active power switches and zero‐current switching of two output‐rectifier diodes in the presented LED driver decrease the switching losses; thus, the circuit efficiency is increased. A prototype driver for powering a 144‐W‐rated LED streetlight module with input utility‐line voltages ranging from 100 to 120 V is implemented and tested. The proposed streetlight driver features cost‐effectiveness, high circuit efficiency, high power factor, low levels of input‐current harmonics, and a digital PWM dimming capability ranging from 20% to 100% output rated LED power, which is fulfilled by a micro‐controller. Satisfying experimental results, including dimming tests, verify the feasibility of the proposed LED streetlight driver. Copyright © 2016 John Wiley & Sons, Ltd.
Age‐related changes in the effects of stress in pregnancy on infant motor development by maternal report: The Queensland Flood Study
Authors: Simcock Gabrielle , Kildea Sue , Elgbeili Guillaume , Laplante David P. , Stapleton Helen , Cobham Vanessa , King Suzanne 
Published: March 2016

ABSTRACTThe current study examined the effects of a natural disaster (a sudden onset flood) as a stressor in pregnancy on infant fine and gross motor development at 2, 6, and 16 months of age. Whether the timing of the stressor in pregnancy or sex of the infant moderated the impact of the prenatal maternal stress on motor development was also explored. Mothers' objective experiences of the flood, emotional reactions and distress, and their cognitive appraisal of the event were assessed retrospectively. Infants' fine and gross motor skills were assessed with the Ages and Stages Questionnaire, and results showed age‐related changes in the effects of prenatal maternal stress on these domains. At 2 months, higher levels of prenatal maternal stress was positively related to infant motor development, yet at 6 and 16 months of age there was a negative association, particularly if flood exposure occurred later in pregnancy and if mothers had negative cognitive appraisals of the event. Results also showed differential effects of the maternal stress responses to the floods on infants' fine and gross motor development at each age and that infant sex did not buffer these effects. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58: 640–659, 2016.
Morphological and niche divergence of pinyon pines
Authors: Ortiz‐Medrano Alejandra , Scantlebury Daniel Patrick , Vázquez‐Lobo Alejandra , Mastretta‐Yanes Alicia , Piñero Daniel 
Published: March 2016

AbstractThe environmental variables that define a species ecological niche should be associated with the evolutionary patterns present in the adaptations that resulted from living in these conditions. Thus, when comparing across species, we can expect to find an association between phylogenetically independent phenotypic characters and ecological niche evolution. Few studies have evaluated how organismal phenotypes might mirror patterns of niche evolution if these phenotypes reflect adaptations. Doing so could contribute on the understanding of the origin and maintenance of phenotypic diversity observed in nature. Here, we show the pattern of niche evolution of the pinyon pine lineage (Pinus subsection Cembroides); then, we suggest morphological adaptations possibly related to niche divergence, and finally, we test for correlation between ecological niche and morphology. We demonstrate that niche divergence is the general pattern within the clade and that it is positively correlated with adaptation.
The challenge of predicting problematic chemicals using a decision analysis tool: Triclosan as a case study
Authors: Perez Angela L , Gauthier Alison M , Ferracini Tyler , Cowan Dallas M , Kingsbury Tony , Panko Julie 
Published: March 2016

Abstract

Manufacturers lack a reliable means for determining whether a chemical will be targeted for deselection from their supply chain. In this analysis, 3 methods for determining whether a specific chemical (triclosan) would meet the criteria necessary for being targeted for deselection are presented. The methods included a list-based approach, use of a commercially available chemical assessment software tool run in 2 modes, and a public interest evaluation. Our results indicated that triclosan was included on only 6 of the lists reviewed, none of which were particularly influential in chemical selection decisions. The results from the chemical assessment tool evaluations indicated that human and ecological toxicity for triclosan is low and received scores indicating that the chemical would be considered of low concern. However, triclosan's peak public interest tracked several years in advance of increased regulatory scrutiny of this chemical suggesting that public pressure may have been influential in deselection decisions. Key data gaps and toxicity endpoints not yet regulated such as endocrine disruption potential or phototoxicity, but that are important to estimate the trajectory for deselection of a chemical, are discussed. Integr Environ Assess Manag 2017;13:198–207. © 2016 SETAC

Key Points
Triclosan appears on 6 out of 122 or 5% of state, federal, and international regulatory and authoritative chemicals lists. The pros and cons of chemical analysis software to predict deselection are discussed. Despite receiving a “green” score of 93% using chemical analysis software, triclosan was marked for deselection based on possible human endocrine effects and aquatic toxicity. Several examples and case studies are presented for other chemicals where “green” grades were computed including 2 other widely used microbiocide chemicals that scored significantly lower than triclosan in their “Green Grade” with scores of 77% and 78%.
Effect of hyaluronic acid in bone formation and its applications in dentistry
Authors: Zhao Ningbo , Wang Xin , Qin Lei , Zhai Min , Yuan Jing , Chen Ji , Li Dehua 
Published: March 2016

AbstractHyaluronic acid (HA), the simplest glycosaminoglycan, participates in several important biological procedures, including mediation of cellular signaling, regulation of cell adhesion and proliferation, and manipulation of cell differentiation. The effect of HA on cell proliferation and differentiation depends on its molecular weight (MW) and concentration. Moreover, the properties of high viscosity, elasticity, highly negative charge, biocompatibility, biodegradability, and nonimmunogenicity make HA attractive in tissue engineering and disease treatment. This review comprises an overview of the effect of HA on cell proliferation and differentiation in vitro, the role of HA in bone regeneration in vivo, and the clinical applications of HA in dentistry, focusing on the mechanism underlining the effect of MW and concentration of HA on cell proliferation and osteogenic differentiation. It is expected that practical progress of HA both in laboratory‐based experiments and clinical applications will be achieved in the next few years. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1560–1569, 2016.
Malaria sporozoite protein expression enhances baculovirus‐mediated gene transfer to hepatocytes
Authors: Tamura Takahiko , Kawabata Chiaki , Matsushita Shunsuke , Sakaguchi Miako , Yoshida Shigeto 
Published: March 2016

AbstractBackgroundBaculovirus vector (BV) is able to transduce foreign genes into mammalian cells efficiently and safely by incorporating a mammalian promoter. In the present study, we tailored the surface proteins expressed by malaria sporozoites to enhance hepatocyte transduction. Sporozoites infect hepatocytes within minutes of initial entry into the blood circulation. Infectivity and hepatocyte‐specific selectivity are mediated by the interplay between hepatocytes and sporozoite surface proteins. The circumsporozoite protein (CSP) and the thrombospondin‐related anonymous protein (TRAP) bind to the heparan sulfate proteoglycan on the hepatocyte surface and contribute to sporozoite infection and hepatocyte selectivity.MethodsBVs displaying an ectodomain consisting of three different CSP variants (full‐length, N‐terminal and C‐terminal) or TRAP on the virus envelope were constructed, and the resulting in vitro hepatocyte transduction efficiency was evaluated.ResultsWe demonstrated improved hepatocyte transduction efficiency in BVs expressing CSP or TRAP ectodomains compared to BVs without malaria surface proteins. In addition, gene transduction efficiencies for BVs displaying CSP or TRAP are higher than those expressing the preS1 antigen of the hepatitis B virus.ConclusionsBVs expressing CSP or TRAP in the ectodomain could represent a promising hepatocyte‐specific gene delivery methodology. Copyright © 2016 John Wiley & Sons, Ltd.
Myocardial extracellular volume fraction measurement in chronic total coronary occlusion: Association with myocardial injury, angiographic collateral flow, and functional recovery
Authors: Chen Yin‐yin , Ren Dao‐yuan , Zeng Meng‐su , Yang Shan , Yun Hong , Fu Cai‐xia , Ge Jun‐bo , Jin Hang , Qian Ju‐ying , Zhang Wei‐guo 
Published: March 2016

PurposeTo investigate whether myocardial extracellular volume fraction (ECV) measurement by cardiac MR is indicative of myocardial injury, angiographic collateral flow, and functional recovery in patients with chronic total coronary occlusion (CTO).Materials and MethodsA total of 50 CTO patients undergoing 1.5 Tesla MR were prospectively enrolled, and 28 underwent a second MR 6 months after revascularization. T1‐mapping based indices, including pre‐ and postcontrast T1 values and ECV, were obtained from infarcted and non‐infarcted myocardium, myocardial segments, and coronary territory. The severity of myocardial injury was rated by transmurality extent of infarction (TEI) and regional wall motion abnormalities (RWMA) score. Angiographic collateral flow was evaluated using Rentrop classification. Improvement in segmental wall motion at 6 months was also assessed.ResultsECV and postcontrast T1 value significantly outperformed precontrast T1 value for identifying myocardial infarction (area under the receiver operating characteristic curve [AUC]: 0.998 and 0.953 versus 0.824, all P < 0.02). Myocardial ECV was strongly correlated with TEI (P = 0.000), RWMA score (P = 0.000), and collateral classification (P = 0.007 for left anterior descending artery [LAD] territory, P = 0.001 for non‐LAD territory). Furthermore, the likelihood of functional recovery was better predicted by ECV than by late gadolinium enhancement (LGE) (AUC: 0.76 versus 0.68, P < 0.02).ConclusionMyocardial ECV may be a useful surrogate to assess myocardial injury and angiographic collateral flow in CTO, and ECV provides incremental value to LGE in assessing functional recovery after revascularization. J. MAGN. RESON. IMAGING 2016;44:972–982.
Variability and bias assessment in breast ADC measurement across multiple systems
Authors: Keenan Kathryn E. , Peskin Adele P. , Wilmes Lisa J. , Aliu Sheye O. , Jones Ella F. , Li Wen , Kornak John , Newitt David C. , Hylton Nola M. 
Published: March 2016

PurposeTo assess the ability of a recent, anatomically designed breast phantom incorporating T1 and diffusion elements to serve as a quality control device for quantitative comparison of apparent diffusion coefficient (ADC) measurements calculated from diffusion‐weighted MRI (DWI) within and across MRI systems.Materials and MethodsA bilateral breast phantom incorporating multiple T1 and diffusion tissue mimics and a geometric distortion array was imaged with DWI on 1.5 Tesla (T) and 3.0T scanners from two different manufacturers, using three different breast coils (three configurations total). Multiple measurements were acquired to assess the bias and variability of different diffusion weighted single‐shot echo‐planar imaging sequences on the scanner‐coil systems.ResultsThe repeatability of ADC measurements was mixed: the standard deviation relative to baseline across scanner‐coil‐sequences ranged from low variability (0.47, 95% confidence interval [CI]: 0.22–1.00) to high variability (1.69, 95% CI: 0.17–17.26), depending on material, with the lowest and highest variability from the same scanner‐coil‐sequence. Assessment of image distortion showed that right/left measurements of the geometric distortion array were 1 to 16% larger on the left coil side compared with the right coil side independent of scanner‐coil systems, diffusion weighting, and phase‐encoding direction.ConclusionThis breast phantom can be used to measure scanner‐coil‐sequence bias and variability for DWI. When establishing a multisystem study, this breast phantom may be used to minimize protocol differences (e.g., due to available sequences or shimming technique), to correct for bias that cannot be minimized, and to weigh results from each system depending on respective variability. J. Magn. Reson. Imaging 2016. J. MAGN. RESON. IMAGING 2016;44:846–855.
Perirenal lymphatic systems: Evaluation using spectral presaturation with inversion recovery T2‐weighted MR images with 3D volume isotropic turbo spin‐echo acquisition at 3.0T
Authors: Matsumoto Shunro , Mori Hiromu , Kiyonaga Maki , Yamada Yasunari , Takaji Ryo , Sato Fuminori , Mimata Hiromitsu , Hijiya Naoki , Moriyama Masatsugu , Tanoue Rika , Tomonari Kenichiro , Matsumoto Tomohiro , Hasebe Terumitsu 
Published: March 2016

PurposeTo evaluate the normal anatomy of the perirenal lymphatics using spectral presaturation with inversion recovery (SPIR) T2‐weighted magnetic resonance imaging (MRI) with 3D volume isotropic turbo spin‐echo acquisition (VISTA) at 3.0T.Materials and MethodsThis retrospective study was approved by the two Institutional Review Boards and informed consent was waived. Thin‐collimated axial images obtained using SPIR T2‐weighted MR imaging sequences with 3D VISTA at 3.0T from 50 patients (100 kidneys) with normal renal function were retrospectively reviewed. The perirenal lymphatic vessels were defined as fluid signal intensity structures on this MRI sequence. Two readers independently assessed the degree of visualization of the perirenal lymphatics using a 4‐point scale in four anatomical regions, including the renal hilar, capsular, communicating pericapsular, and subfascial lymphatics, and interobserver agreement was evaluated with weighted kappa statics. The detectability of each lymphatic system was calculated for each reader using confidence level ratings of grades 1 and 2 as positive and grades 3 and 4 as negative.ResultsInterobserver agreement for the visualization grades was almost perfect (kappa value = 0.9). The renal hilar lymphatics along the renal vein were clearly identified in all patients. The detectability of other perirenal lymphatics was 44% for the capsular lymphatics, 39% for communicating pericapsular lymphatics, and 22% for the subfascial lymphatics. There was no laterality regarding the detectability of the perirenal lymphatics.ConclusionThe findings of this study support the feasibility of SPIR T2‐weighted MR images with 3D‐VISTA at 3.0T for evaluating the perirenal lymphatic systems. J. MAGN. RESON. IMAGING 2016;44:897–905.