bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Method for Precision Evaluation of 3D Printing‐based System for Pelvic Tumor Resection and Reconstruction
Authors: Wu Junxiang , Luo Dinghao , Ran Zhaoyang , Wu Wen , Wang Lei , Hao Yongqiang 
Published: September 2024

Abstract

Background:
Three-dimensional (3D)-printed osteotomy guides and personalized 3D-printed prostheses have been used in pelvic tumor resection and reconstruction, and achieved good results. However, there is a lack of methods to evaluate its precision. This study aimed to establish a novel method to evaluate the precision of osteotomy and prosthesis installation using our 3D printing-based system in pelvic tumor surgeries.
Methods:
A retrospective analysis was conducted on 24 patients with malignant pelvic tumors who underwent surgery with 3D-printed osteotomy guides and personalized prostheses between April 2014 and June 2024. Data regarding the preoperative design plans and postoperative follow-up imaging were collected. Additionally, 3D reconstruction was conducted to compare and measure. The deviation was categorized into “Excellent” (±5 mm), “Good” (±10 mm), and “Fair” (±10 mm and above). The deviation distance of osteotomy was defined as the absolute value of the difference between the actual safe distance and preoperatively planned safety margin. The deviation distance of acetabular center was defined as the straight-line distance between preoperatively planned acetabular center and the reconstructed acetabular center.
Results:
The osteotomy satisfaction rate was 87.5%, with 21 cases classified as “Excellent” and 3 as “Good”. The average deviation distance of osteotomy using 3D-printed guides was 2.74 ± 2.36mm (range, 0.13–9.29 mm). The average deviation distance of the acetabular centers reconstructed with 3D-printed personalized prostheses was 5.57 ± 3.71mm (range, 0.91–15.94 mm).
Conclusions:
The study provides a theoretical basis for the postoperative precision evaluation of 3D printing‐based system for pelvic tumor resection and reconstruction.
Chronic Treatment with SGLT-2 Inhibitors is Associated with ICU Admission and Disease Severity in Patients with Diabetic Ketoacidosis: A Propensity Score–Matched Cohort Study
Authors: Sebastian-Valles Fernando , Tapia-Sanchiz Maria Sara , Navas-Moreno Víctor , López-Ruano Marta , Martínez-Otero Carmen , Carrillo-Lopez Elena , Ganga Carolina Sager-La , Raposo-López Juan José , Amar Selma , Gonzalez-Castañar Sara , Teleki Andres Von Wernitz , Arco Carmen del , Martin Jose Alfonso Arranz , Marazuela Monica 
Published: September 2024

Abstract

Introduction: SGLT-2 inhibitors (SGLT-2i) are linked to a higher risk of diabetic ketoacidosis (DKA). However, it is still unclear whether the severity of SGLT-2i associated DKA is higher.
Methods: This is a retrospective cohort study with patients admitted for DKA at a tertiary hospital (2013-2024). Patients were matched by propensity score for age, sex, diabetes duration, type, and ischemic heart disease. ICU admission risk and clinical severity were compared between SGLT-2i users and controls.
Results: The matched sample included 105 subjects (35 SGLT-2i users, 70 controls). The average age was 63.1±15.4 years, and 40 (38.1%) patients were women. ICU admission was higher in the treatment group (65.7% versus 24.6%, p<0.001). A conditional logistic regression showed higher risk of ICU admission in the treatment group (odds ratio 12.7, 95% confidence interval 1.9 - 84.3, p=0.009) after adjusting for confounding factors. The treatment group exhibited less favorable blood gas results (pH 7.10±0.17 vs 7.18±0.16, p=0.024) and shorter symptom duration (2 [1-3] vs 3 [2-7] days, p<0.002). No significant differences were found in diabetes type, ketonemia, creatinine, or DKA precipitating factors.
Conclusion: DKA in patients with diabetes treated with SGLT-2i is associated with more severe acidosis with quicker onset, leading to higher risk of ICU admission compared to patients not receiving this treatment. We recommend temporary discontinuation of SGLT-2i during any acute event until resolution, regardless of diabetes type or the patient's glycemic control.
Investigation of the Contrast Changing of Copper Surfaces in the Laser Marking Process
Authors: Lazov Lyubomir , Teirumnieks Edmunds , Yankov Emil , Angelov Nikolay , Ghalot Risham Singh 
Published: September 2024

Abstract

The surface treatment for product marking indicates a significant impact on the recognition of a product by an electronic reader for both the manufacturer and the end customer. This is achieved by receiving a unique code, which must be robust and durable over time. This paper investigates the influence of technological parameters speed, raster step, pulse duration, power density and effective energy on the marking of copper samples with Yb-doped fiber and CuBr MOPA lasers. The studies were conducted in two groups: on the one hand, for pulses with 100 ns and 200 ns duration for the fiber laser and on the other hand, for pulses with 30 ns duration for the copper bromide laser. The speed change in these experiments varied across the interval from 10 mm/s to 80 mm/s. The raster step intervals are from 3 µm to 20 µm for the fiber laser and from 3 µm to 27 µm for the CuBr laser. The results are compared at different pulse durations of the fiber laser and the role of the wavelengths of the two types of lasers on the technological process is investigated. Optimal intervals for visual perception of information have been determined for the effective energy in raster marking with Yb-doped fiber and CuBr lasers. For the fiber laser it is from 17.4 kJ/cm2 to 43.1 kJ/cm2 and for the copper bromide laser from 9.90 kJ/cm2 to 43.1 kJ/cm2.
Metabolomics Approach Reveals Key Plasma Biomarkers for Tumor Biology in Multiple Myeloma
Authors: Wang Xiaoxue , Cheng Longhao , Liu Aijun , Liu Lihong , Gong Lili , Shen Guolin 
Published: September 2024

Abstract

Background
Multiple myeloma (MM) is the most aggressive and prevalent primary malignant tumor within the blood system, and can be classified into grades RISS-I, II, and III. High-grade tumors are associated with decreased survival rates and increased recurrence rates. To better understand metabolic disorders and expand the potential targets for MM, we conducted large-scale untargeted metabolomics on plasma samples from MM patients and healthy controls (HC).
Methods
Our study included thirty-three HC, thirty-eight newly diagnosed MM patients (NDMM) categorized into three RISS grades (grade I: n = 5; grade II: n = 19; grade III: n = 8), and ninety-two MM patients post-targeted therapy with bortezomib-based regimens. Metabolites were analyzed and identified using ultra high liquid chromatography coupled with Q Orbitrap mass spectrometry (UPLC-HRMS), followed by verification through a self-built database.
Results
Compared with HC participants, seventy metabolites, primarily associated with the citrate cycle, amino acids and glycerophospholipid/sphingolipid metabolism, and nine metabolic pathways (citrate cycle, choline metabolism, glyceropholipid metabolism, sphingolipid metabolism, valine, leucine and isoleucine biosynthesis, etc.) exhibited significant changes in NDMM. Notably, lactic acid and leucine have emerged not only as diagnostic biomarkers but also as markers for tumor monitoring in staging and prognosis, respectively.
Conclusion
Our findings on key metabolites and metabolic pathways provide novel insights into the exploration of diagnostic and therapeutic targets for MM. A prospective study is essential to validate these discoveries for future MM patient care.
GluR2 overexpression in ACC glutamatergic neurons alleviates cancer-induced bone pain in rats
Authors: Ba Futing , Wei Jinrong , Feng Qi-Yan , Yu Chen-Yang , Song Meng-Xue , Hu Shufen , Xu Guang-Yin , Zhang Hai-Long , Jiang Guo-Qin 
Published: September 2024

Abstract

Background Cancer-induced bone pain (CIBP) is a complex chronic pain with poorly understood mechanisms. The anterior cingulate cortex (ACC) plays a critical role in processing and modulating chronic pain. This study investigates how the GluR2 receptors (calcium impermeable AMPA receptors) in ACC glutamatergic neurons regulate CIBP. Methods The CIBP models were established by injecting Walker 256 cells into the tibia of SD rats. Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) were used as indicators of hyperalgesia. The immunofluorescence staining was employed to detect the expression of c-Fos in ACC and identify the subtypes of co-labeled c-Fos+neurons. Real-time monitoring of calcium activity in ACC glutamatergic neurons was achieved through the fiber photometry. The excitability of glutamatergic neurons in ACC was modulated using chemicalgenetics and optogenetics techniques. The expression of GluR2 at the mRNA and protein level in ACC were assessed using RT-qPCR and Western blotting. Results There were significant reductions in PWT and PWL of CIBP rats after Walker 256 cell injection. The ACC of CIBP rats showed increased c-Fos expression compared to sham rats, with mainly activated c-Fos co-localized with glutamatergic neurons. Optogenetic or chemogenetic activation of ACC glutamatergic neurons led to increased hyperalgesia in sham rats, while suppression of their activity alleviated hyperalgesia in CIBP rats. Calcium activity in ACC glutamatergic neurons of CIBP rats was increased with suprathreshold stimulation of von Frey filament. Notably, surface GluR2 protein and mRNA were reduced in ACC of CIBP rats. Furthermore, overexpression of GluR2 by AAV-CaMKIIα-GluR2 injection was decreased c-Fos expression in ACC and alleviated hyperalgesia in CIBP rats. Conclusions These findings suggest that decreased surface GluR2 receptors in ACC glutamatergic neurons contribute to calcium activity and excessive excitability, thereby inducing CIBP in rats. Conversely, GluR2 overexpression in ACC glutamatergic neurons alleviates CIBP in rats. This study provides a new potential therapeutic approach for targeting the GluR2 receptor to alleviate CIBP for cancer patients.
Submesoscale Eddy-induced Nutrient Upwelling in the Upstream Kuroshio Current Forms Ecological Hotspot
Authors: Gomez Gloria Duran , Nagai Takeyoshi 
Published: September 2024

Abstract

While the Kuroshio, a western boundary current in the North Pacific, transports a large amount of nutrients in dark subsurface layers, it has been unclear whether these subsurface nutrients are supplied to continental shelves along southern coast of Japan. Recent observations revealed that the upstream Kuroshio flowing through rough topography forms a large-scale turbulence hotspot that may supply nutrients to sunlit surface layers. However, the Kuroshio-Island interaction in this region may also induce eddies and nutrient upwelling which have neither been observed directory nor quantified. Here, through high-resolution in-situ observations, we show submesoscale ~10 km nutrient structures along isopycnals, suggestive of eddy-induced upwelling. High-resolution simulations reproduce these features generated by submesoscale cyclonic eddy-induced nitrate upwelling at O(10 mmol m-2day-1), accounting ~9% of net primary production in the area 400 km downstream. Submesoscale eddies in the upstream Kuroshio partly explain how the Kuroshio sustains high biodiversity and biological production.
Blue Light-Emitting Diode Therapy for Recurrent Vulvovaginal Candidiasis: A Brazilian Report
Authors: Modesto Waleska , Frederice Claudia , Bardin Marcela 
Published: September 2024

Abstract

Objective
We conducted a prospective study with the objective of assessing the effects of antimicrobial blue light (ABL) therapy for recurrent vulvovaginal candidiasis (RVVC) in drug-resistant women.
Introduction:
RVVC is defined as three or more episodes of candidiasis in a 12-month period. Conventional treatment is complex and often involves long-term or multiple treatments. ABL therapy is a promising treatment option as it is acceptable to women and has with few side effects.
Methods
Our study enrolled RVVC drug-resistant women, who received ABL through 10 sessions for 20 minutes once a week from January 2023 to January 2024. All women were followed up by 6 months after therapy.
Results
We included 62 patients. The overall positive response rates were 79% immediately after treatment and 58% after 6 months, respectively. There was an improvement in the symptoms of pruritus, burning, oedema, erythema and leucorrhoea.
Conclusion
ABL was an effective therapy to be employed in drug-resistant women suffering from RVVC.
Carboniferous Lithofacies and paleogeography of the Hexi Corridor Basins, China
Authors: ya Tian , zhongkai Bai , youxing Yang , Zhili Du , lihong Liu 
Published: September 2024

Abstract

The Hexi Corridor Basin Group, which is rich in Carboniferous source rocks, has become a key target for oil and gas exploration. The extensive distribution and oil and gas indications in dark mudstone within the Carboniferous strata illustrate promising prospects for good oil and gas in the region. The lithofacies and paleogeography of the Carboniferous in the Hexi Corridor Basin Group are analyzed through fieldwork, drilling and geochemistry. The Basin Group is characterized by extensive transgressive deposits. At the end of the deposition of the Yanghugou Formation, transgression over the uplifted area on the western margin of the Ordos region was ovvurring, and the Qilian Sea was connected with the North China Sea in the Ordos region. A braided river facies was superseded by a barrier-lagoon facies, accompanied by the formation of peat swamps and the subsequent formation of coal seams. In the Late Carboniferous, a meandering river facies became characteristic, while the barrier-lagoon facies was more widely developed in combined marine and continental setting. The lithofacies and paleogeography were influenced by the presence of significant faults and a paleotopography.
The Relationship Between Leisure-time Physical Activity and Sleep Disorders in American Adults
Authors: Yang Juxiang , Zheng Xi , Song Gang 
Published: September 2024

Abstract

Objective
This study aims to explore the relationship between different domains of physical activity and sleep disorders.
Methods
We included 20,597 participants (aged ≥ 18 years) from the National Health and Nutrition Examination Survey (NHANES) (2007–2014). Restricted cubic spline models were utilized to explore the nonlinear relationship between leisure-time physical activity (LTPA) and sleep disorders, as well as its gender differences.
Results
1) Among different domains of physical activity, only LTPA showed a strong association with sleep disorders. 2) Participants engaging in LTPA according to the recommended levels (< 1 time (1-149 minutes/week), 1–2 times (150–299 minutes/week), or ≥ 2 times (300 minutes/week)) experienced a respective decrease in the risk of sleep disorders by 16% (OR 0.84, 95% CI 0.72–0.98), 19% (OR 0.81, 95% CI 0.68–0.96), and 26% (OR 0.74, 95% CI 0.64–0.85). 3) Stratified analysis by different strata (defined by age, gender, race, economic status, education, marital status, BMI, and smoking status) did not reveal any interaction with leisure-time physical activity. 4) Restricted cubic spline graphs (RCS) demonstrated a negative correlation between leisure-time physical activity and the risk of sleep disorders in males, while a U-shaped relationship was observed in females.
Conclusion
For sleep disorders, males appear to benefit from higher levels of leisure-time physical activity, whereas for females, more does not necessarily translate to greater benefits. However, irrespective of gender, marital status, education, economic status, and smoking status, engaging in leisure-time physical activity consistent with PA guidelines is associated with a lower risk of sleep disorders.
Intraoperative surgical complications of open surgery for congenital diaphragmatic hernia: A multicenter, observational study in Japan
Authors: Terui Keita , Nagata Kouji , Yamoto Masaya , Sato Yoshiaki , Okuyama Hiroomi , Maruyama Hidehiko , Yokoi Akiko , Kim Kiyokazu , Masumoto Kouji , Okazaki Tadaharu , Inamura Noboru , Toyoshima Katsuaki , Koike Yuhki , Yazaki Yuta , Sato Yasunori , Usui Noriaki 
Published: September 2024

Abstract

Purpose: This study aimed to clarify surgical complications associated with open surgery for congenital diaphragmatic hernia (CDH).
Methods: We performed an exploratory data analysis of the clinical characteristics of surgical complications of neonates with CDH who underwent laparotomy or thoracotomy between 2006 and 2021. Data of these patients were obtained from the database of the Japanese CDH Study Group.
Results: Among 1,111 neonates with left or right CDH, 852 underwent open surgery (laparotomy or thoracotomy). Of these 852 neonates, 51 had the following surgical complications: organ injury (n=48; 6% of open surgeries); circulatory failure caused by changes in the organ location (n=2); and skin burns (n=1). Injured organs included the spleen (n=30; 62% of organ injuries), liver (n=7), lungs (n=4), intestine (n=4), adrenal gland (n=2), and thoracic wall (n=2). Fourteen of the patients who experienced organ injury required a blood transfusion (2% of open surgeries). The adjusted odds ratio of splenic injury for patients with non-direct closure of the diaphragm was 2.2 (95% confidence interval, 1.1–4.9).
Conclusion: Of the patients who underwent open surgery for CDH, 2% experienced organ injury that required a blood transfusion. Non-direct closure of the diaphragmatic defect was a risk factor for splenic injury.
Post-NACA Aerodynamics: Optimizing H-Darrieus VAWT Design with CFD Simulations of Novel J-Blades
Authors: Abdallah Ahmed , William Micheal A. , Zidane Iham F. 
Published: September 2024

Abstract

As the demand for sustainable energy sources continues to rise, improving the efficiency of existing renewable technologies is crucial. This study investigates the aerodynamic performance of a novel J-shaped blade design for H-Darrieus VAWT with the objective of enhancing starting torque and overall efficiency. A 2D URANS CFD model was employed to simulate the airflow around the J-shaped blades. The model underwent a comprehensive verification and validation process. This rigorous approach ensured the model's fidelity, enabling a systematic comparison of the J-shaped blade's aerodynamic performance with conventional NACA0015 airfoils. The numerical analysis reveals a significant enhancement in starting torque, with a 142% increase observed at low tip speed ratios (λ = 0.2). This finding positions the J-shaped blade as a promising solution to address the challenge of initiating rotation in low-wind environments, particularly relevant for urban applications. Furthermore, the simulations demonstrate comparable torque production between the J-shaped blade and the NACA0015 airfoil under typical operating conditions. The J-shaped blade exhibits improved torque uniformity and reduced wake turbulence intensity. This study highlights the potential of the J-shaped blade design to revolutionize VAWT technology by offering advancements in increased efficiency, reduced fatigue stresses on the turbine structure, and optimized energy generation.
Diagnostic Accuracy of Referral Biopsy Compared to Optical Biopsy in Large Non- Pedunculated Colorectal Polyps
Authors: Gorelik Yuri , Korytny Alexander , Arraf Tarek , Arsheid Nour , Mazzawi Fares , Awadie Halim , Klein Amir 
Published: September 2024

Abstract

Background
Endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (LNPCPs) offers excellent efficacy and safety. Referral biopsies are commonly obtained prior to EMR despite their potential adverse effects. We aimed to assess the diagnostic accuracy of referral biopsy as compared with optical evaluations and the polyp’s final pathology.
Methods
We analyzed a cohort from two centers that included adult patients referred for EMR of LNPCPs between 2017 and 2022. The NICE classification system was used for optical classification. We compared procedural outcomes of lesions with or without a referral biopsy and diagnostic accuracy of referral biopsy and optical evaluation to the final histopathology of the resected polyp.
Results
Of 605 EMR procedures, 398 (65.8%) had referral biopsies. Polyp size was larger in the biopsy group. No significant differences were observed in en-bloc resection rate, adequate lifting, procedural bleeding, or surveillance recurrence rates. Optical biopsies had higher diagnostic concordance with final histology (Cohen’s Kappa 0.62 vs. 0.55) and enhanced sensitivity for sessile serrated polyps/hyperplastic polyps (SSP/HP) and cancer as compared to referral biopsies (0.75 vs. 0.72, P<0.01, and 0.19 vs. 0.0, p<0.01, respectively). Optical evaluation was more accurate in non-biopsied lesions.
Conclusions
Referral biopsies do not offer additional diagnostic accuracy and may reduce the accuracy of optical evaluation for LNPCPs.
An Investigative Study on Depression Among Clinical Medical Students in Private Universities in North Central Nigeria
Authors: Obilade Titilola , Koleoso Peter O. , Nwenendah-Mpi Emelda W. 
Published: September 2024

Abstract

Background
Depression is among known mental health conditions and students in schools of medicine are not immune to it. In this investigative study, 211 clinical medical students of two private universities from North-Central Nigeria were examined on depression prevalence, the contributory factors and their coping strategies.
Methods
The Patient Health Questionnaire 9 (PHQ-9), the Medical Student’s Stressor Questionnaire (MSSQ) and identified coping strategies according to Coping Oriented to Problems Experienced Inventory (COPE) were instruments of data collection.
Results
The results were obtained by both descriptive analysis and test of association between some categorical variables. The depression prevalence amongst the participants was 159 (75.4%). Females (124 (78.0%)) were more depressed than males (35 (22.0%)). Factors identified as contributing to depression were the heavy academic workload (124 (78.5%)), insufficient family time (93 (58.1%)) and financial constraints (54 (34.0%)). The most utilized method of coping with their stress was engaging on social media (133 (84.2%)), followed by talking with relatives or friends (99 (62.7%)) and use of recreational drugs (20 (12.8%)). The findings from this study have shown that more than three-quarters of the respondents suffered from varying degrees of depression from mild, 63 (29.9%), moderate, 53 (25.1%) to severe, 43 (20.4%).
Conclusions
The heavy academic workload was a major source of depression. Colleges of Medicine should take pro-active steps towards their students’ mental health and academic workload should be well spaced to reduce the stress imposed by the frequency of examinations.