bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interfacial Chemistry‐Modified QD‐Coupled CdTe Solid Nanowire and Its Hybrid with Graphene Quantum Dots for Enhanced Photocurrent Properties
Authors: Premkumar Sellan , Nataraj Devaraj , Bharathi Ganapathi , Khyzhun Oleg Yu , Thangadurai T. Daniel 
Published: December 2017

AbstractHere in, we report the formation of CdTe quantum dot interconnected solid nanowire network by a bottom up process. The as formed nanostructure, also, named as quantum dot solid structure has exhibited a high magnitude photocurrent value of 0.25 mA, corresponding to the biasing voltage of 1.5 V. The improved photocurrent generation is a consequence of suppressed inter‐dot charge transport resistance upon quantum solid nanowire network formation. This interesting network structure was further decorated with graphene quantum dots by optimizing the growth parameters. The hybrid nanostructure has shown a further enhancement in the photocurrent generation. Formation of such new nanostructures and their interesting photo‐physical properties are discussed in detail.
A New Facile Synthesis of Tungsten Oxide from Tungsten Disulfide: Structure Dependent Supercapacitor and Negative Differential Resistance Properties
Authors: Mandal Debasish , Routh Parimal , Nandi Arun K. 
Published: December 2017

AbstractTungsten oxide (WO3) is an emerging 2D nanomaterial possessing unique physicochemical properties extending a wide spectrum of novel applications which are limited due to lack of efficient synthesis of high‐quality WO3. Here, a facile new synthetic method of forming WO3 from tungsten sulfide, WS2 is reported. Spectroscopic, microscopic, and X‐ray studies indicate formation of flower like aggregated nanosized WO3 plates of highly crystalline cubic phase via intermediate orthorhombic tungstite, WO3.H2O phase. The charge storage ability of WO3 is extremely high (508 F g−1 at current density of 1 A g−1) at negative potential range compared to tungstite (194 F g−1 at 1 A g−1). Moreover, high (97%) capacity retention after 1000 cycles and capacitive charge storage nature of WO3 electrode suggest its supremacy as a negative electrode of supercapacitors. The asymmetric supercapacitor, based on the WO3 as a negative electrode and mildly reduced graphene oxide as a positive electrode, manifests high energy density of 218.3 mWhm−2 at power density 1750 mWm−2, and exceptionally high power density, 17 500 mW m−2, with energy density of 121.5 mWh m−2. Furthermore, the negative differential resistance (NDR) property of both WO3 and WO3.H2O are reported for the first time and NDR is explained with density of state approach.
Generalized Synthesis of Ultrathin Cobalt‐Based Nanosheets from Metallophthalocyanine‐Modulated Self‐Assemblies for Complementary Water Electrolysis
Authors: Wu Hao , Chen Zhimin , Zhang Jialin , Wu Feng , Xiao Fei , Du Shichao , He Chunying , Wu Yiqun , Ren Zhiyu 
Published: December 2017

AbstractThe development of effective approaches for preparing large‐area, self‐standing, ultrathin metal‐based nanosheets, which have proved to be favorable for catalytic applications such as water electrolysis, is highly desirable but remains a great challenge. Reported herein is a simple and versatile strategy to synthesize ultrathin Co3O4 and CoP NSs consisting of close‐packed nanoparticles by pyrolyzing cobalt(II) phthalocyanine/graphene oxide (CoPc/GO) assemblies in air and subsequent topotactic phosphidation while preserving the graphene‐like morphology. The strong π–π stacking interactions between CoPc and GO, and the inhibiting effect of the tetrapyrrole‐derived macrocycle for grain growth during the catalytic carbon gasification contribute to the NSs forming. The resulting homologous Co3O4 and CoP NSs display outstanding catalytic activity in alkaline media toward the oxygen evolution reaction and the hydrogen evolution reaction, respectively, ascribed to the richly exposed active sites, and the expedited electrolyte/ion transmission path. The integrated asymmetrical two‐electrode configuration also presents a superior cell voltage of 1.63 V at 10 mA cm−2 for overall water splitting, accompanied with the excellent durability during long‐term cycling. Further evidences validate that this strategy is appropriate to fabricate graphene‐like ultrathin NSs of many other metal oxides, such as Fe2O3, NiO, MoO3, and mixed‐metal oxides, for various applications.
A Novel Algorithm for Lifetime Extrapolation, Prediction, and Estimation of Emerging PV Technologies
Authors: Rizzo Antonio , Cester Andrea , Madsen Morten V. , Krebs Frederik C. , Gevorgyan Suren A. 
Published: December 2017

AbstractAccurate determination of the lifetime of novel hybrid and organic solar cells is often rather challenging due to the very dynamic behavior of such cells over time and ageing curves with shapes of varying nature. Therefore, in order to accurately and reproducibly determine the lifetime of photovoltaic devices with such a behavior, a novel elaboration algorithm is developed, which enables automatic smoothing, filtering, and extrapolation of the real lifetime data and reproducible determination of the lifetime parameters defined in the International Summit on OPV Stability guiding standards. The algorithm is also capable of predicting the lifetime of devices, not tested until the end of sample life, given that there is sufficient number of measured data points to perform reliable extrapolation of ageing curves (to a limited time frame). The algorithm is discussed in detail and a range of examples for different lifetime data are presented.
Collection of blood from wild‐caught mice (Peromyscus) via submandibular venipuncture
Authors: Berl Jacob L. , Voorhees Matthew W. , Wu Jonathan W. , Flaherty Elizabeth A. , Swihart Robert K. 
Published: December 2017

ABSTRACSubmandibular venipuncture is a common technique used to harvest whole blood from laboratory‐strain mice, but its effectiveness on wild‐caught Peromyscus spp. has not been formally tested. We used submandibular venipuncture to collect repeated blood samples from 30 wild‐caught deer mice (Peromyscus maniculatus) and white‐footed mice (P. leucopus) in captivity and used a capture–mark–recapture field study to evaluate the influence of blood collection on apparent survival of deer mice in wild populations in Tippecanoe County, Indiana, USA in 2015–2016. We were able to collect sufficient (0.05–0.10 mL) whole‐blood samples rapidly (within <1 min) without the use of anesthesia. The procedure caused only localized tissue damage; puncture sites generally healed within 24 hours. We documented 1 case of venipuncture‐induced mortality in 73 blood collections (1.3%) from captive Peromyscus, and found no influence of blood collection on apparent survival of wild deer mice. We found submandibular venipuncture to be an efficient and humane procedure that is well‐suited for field conditions when proper technique is used; small mammal researchers should consider its use instead of traditional methods involving bleeding from the retro‐orbital sinus or tail clipping. © 2017 The Wildlife Society.
Piecing together cis‐regulatory networks: insights from epigenomics studies in plants
Authors: Huang Shao‐shan C. , Ecker Joseph R. 
Published: December 2017

5‐Methylcytosine, a chemical modification of DNA, is a covalent modification found in the genomes of both plants and animals. Epigenetic inheritance of phenotypes mediated by DNA methylation is well established in plants. Most of the known mechanisms of establishing, maintaining and modifying DNA methylation have been worked out in the reference plant Arabidopsis thaliana. Major functions of DNA methylation in plants include regulation of gene expression and silencing of transposable elements (TEs) and repetitive sequences, both of which have parallels in mammalian biology, involve interaction with the transcriptional machinery, and may have profound effects on the regulatory networks in the cell. Methylome and transcriptome dynamics have been investigated in development and environmental responses in Arabidopsis and agriculturally and ecologically important plants, revealing the interdependent relationship among genomic context, methylation patterns, and expression of TE and protein coding genes. Analyses of methylome variation among plant natural populations and species have begun to quantify the extent of genetic control of methylome variation vs. true epimutation, and model the evolutionary forces driving methylome evolution in both short and long time scales. The ability of DNA methylation to positively or negatively modulate binding affinity of transcription factors (TFs) provides a natural link from genome sequence and methylation changes to transcription. Technologies that allow systematic determination of methylation sensitivities of TFs, in native genomic and methylation context without confounding factors such as histone modifications, will provide baseline datasets for building cell‐type‐ and individual‐specific regulatory networks that underlie the establishment and inheritance of complex traits.This article is categorized under:

Laboratory Methods and Technologies > Genetic/Genomic Methods
Biological Mechanisms > Regulatory Biology
Erectile Dysfunction Medications and Treatment for Cardiometabolic Risk Factors: A Pharmacoepidemiologic Study
Authors: Skeldon Sean C. , Cheng Lucy , Morgan Steven G. , Detsky Allan S. , Goldenberg S. Larry , Law Michael R. 
Published: December 2017

Abstract

Background
Erectile dysfunction (ED) can be a sentinel marker for future cardiovascular disease and has been described as providing a “window of curability” for men to receive targeted cardiovascular risk assessment.

Aim
To determine whether the prescription of phosphodiesterase type 5 inhibitors (PDE5is) for ED leads to the detection and treatment of previously undiagnosed cardiometabolic risk factors.

Methods
We performed a retrospective population-based cohort study of residents of British Columbia, Canada using linked health care databases from 2004 to 2011. An individual-level time series analysis with switching replications was used to determine changes in drug use for hypertension, hypercholesterolemia, and diabetes in men 40 to 59 years old. The observation window for each patient was 720 days before and 360 days after the index date.

Outcomes
The primary outcome was changes in prescriptions for antihypertensive, statin, and oral antidiabetic drugs, with secondary outcomes being laboratory tests for plasma cholesterol and glucose.

Results
5,858 men 40 to 59 years old newly prescribed a PDE5i were included in the analysis. We found a sudden increase in prescriptions for antihypertensive drugs (40 per 1,000; P &lt; .001), statins (10 per 1,000; P = .001), and antidiabetic drugs (17 per 1,000; P = .002) in the 90 days after a new prescription for a PDE5i. For hypercholesterolemia and diabetes, most of this change was observed in men with relevant screening tests performed in the 30 days after their PDE5i prescription. Only 15% and 17% of men who did not have a screening test for cholesterol and glucose, respectively, in the year before their PDE5i prescription went on to have one in the subsequent 30 days.

Clinical Implications
The paucity of screening tests observed in our study after PDE5i prescriptions suggests that physicians should be educated on the recommended screening guidelines for men newly diagnosed with ED.

Strengths and Limitations
The number of men who were ordered a laboratory test or written a prescription but chose not to complete or fill it, respectively, is unknown.

Conclusion
Treatment for ED with PDE5is can be a trigger or “gateway drug” for the early detection and treatment of cardiometabolic risk factors provided physicians perform the requisite screening investigations.
EMS Coverage of a Female-Only Event with 10,000 Attendees: Preparation and Implementation in One Week
Authors: AlAssaf Wajdan Ibrahim 
Published: December 2017

AbstractThis report describes the medical coverage provided for 10KSA, a charity event held in Saudi Arabia for breast cancer awareness. More than 10,000 women attended the event. A total of 41 attendees sought medical care; four patients (9.8%) presented directly to the clinic and 37 patients (90.2%) presented to the first aid units, mostly for check-ups. This report may be helpful for care providers arranging medical coverage for future events with similar challenging situations (women only, distant location).AlAssafWI. EMS coverage of a female-only event with 10,000 attendees: preparation and implementation in one week. Prehosp Disaster Med. 2017;32(6):694–698.
Complexity in eating disorders: a case for simple or complex formulation and treatment?
Authors: Mountford Victoria A. , Tatham Madeleine , Turner Hannah , Waller Glenn 
Published: December 2017

AbstractEating disorders are commonly regarded as complex psychiatric conditions, although this perception might be a product of the high levels of physical and psychological co-morbidity that are present in many such cases, rather than being about complexity in the eating disorderper se. This paper will consider the reasons that eating disorders are seen as complex, and whether or not that perceived complexity should be seen as a genuine reason to deviate from existing evidence-based cognitive behavioural therapy (CBT) protocols. Case examples will be used to illustrate how complex presentations can require clinicians to work skilfully with relatively simple formulations to achieve the best outcome, rather than using unnecessarily complex formulations and treatments. The importance of clear supervision is also stressed, as it can play a role in clinicians’ perception of the need for a complex or simple formulation, it can support the clinician in developing a collaborative, focused and efficient formulation, and it can keep the clinician on track with an evidence-based CBT approach.
NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A
Authors: Wu Chenglei , Su Zexiong , Lin Meng , Ou Jiayu , Zhao Wei , Cui Jun , Wang Rong-Fu 
Published: December 2017

AbstractThe adaptor protein TRAF6 has a central function in Toll-like receptor (TLR) signalling, yet the molecular mechanisms controlling its activity and stability are unclear. Here we show that NLRP11, a primate specific gene, inhibits TLR signalling by targeting TRAF6 for degradation. NLRP11 recruits the ubiquitin ligase RNF19A to catalyze K48-linked ubiquitination of TRAF6 at multiple sites, thereby leading to the degradation of TRAF6. Furthermore, deficiency in either NLRP11 or RNF19A abrogates K48-linked ubiquitination and degradation of TRAF6, which promotes activation of NF-κB and MAPK signalling and increases the production of proinflammatory cytokines. Therefore, our findings identify NLRP11 as a conserved negative regulator of TLR signalling in primate cells and reveal a mechanism by which the NLRP11-RNF19A axis targets TRAF6 for degradation.
Structural insights into the potency of SK channel positive modulators
Authors: Nam Young-Woo , Orfali Razan , Liu Tingting , Yu Kunqian , Cui Meng , Wulff Heike , Zhang Miao 
Published: December 2017

AbstractSmall-conductance Ca2+-activated K+ (SK) channels play essential roles in the regulation of cellular excitability and have been implicated in neurological and cardiovascular diseases through both animal model studies and human genetic association studies. Over the past two decades, positive modulators of SK channels such as NS309 and 1-EBIO have been developed. Our previous structural studies have identified the binding pocket of 1-EBIO and NS309 that is located at the interface between the channel and calmodulin. In this study, we took advantage of four compounds with potencies varying over three orders of magnitude, including 1-EBIO, NS309, SKS-11 (6-bromo-5-methyl-1H-indole-2,3-dione-3-oxime) and SKS-14 (7-fluoro-3-(hydroxyimino)indolin-2-one). A combination of x-ray crystallographic, computational and electrophysiological approaches was utilized to investigate the interactions between the positive modulators and their binding pocket. A strong trend exists between the interaction energy of the compounds within their binding site calculated from the crystal structures, and the potency of these compounds in potentiating the SK2 channel current determined by electrophysiological recordings. Our results further reveal that the difference in potency of the positive modulators in potentiating SK2 channel activity may be attributed primarily to specific electrostatic interactions between the modulators and their binding pocket.
CRISPR/Cas9 delivery with one single adenoviral vector devoid of all viral genes
Authors: Ehrke-Schulz Eric , Schiwon Maren , Leitner Theo , Dávid Stephan , Bergmann Thorsten , Liu Jing , Ehrhardt Anja 
Published: December 2017

AbstractThe Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 system revolutionized the field of gene editing but viral delivery of the CRISPR/Cas9 system has not been fully explored. Here we adapted clinically relevant high-capacity adenoviral vectors (HCAdV) devoid of all viral genes for the delivery of the CRISPR/Cas9 machinery using a single viral vector. We present a platform enabling fast transfer of the Cas9 gene and gRNA expression units into the HCAdV genome including the option to choose between constitutive or inducible Cas9 expression and gRNA multiplexing. Efficacy and versatility of this pipeline was exemplified by producing different CRISPR/Cas9-HCAdV targeting the human papillomavirus (HPV) 18 oncogene E6, the dystrophin gene causing Duchenne muscular dystrophy (DMD) and the HIV co-receptor C-C chemokine receptor type 5 (CCR5). All CRISPR/Cas9-HCAdV proved to be efficient to deliver the respective CRISPR/Cas9 expression units and to introduce the desired DNA double strand breaks at their intended target sites in immortalized and primary cells.
Integrated DNA methylome and transcriptome analysis reveals the ethylene-induced flowering pathway genes in pineapple
Authors: Wang Jiabin , Li Zhiying , Lei Ming , Fu Yunliu , Zhao Jiaju , Ao Mengfei , Xu Li 
Published: December 2017

AbstractEthylene has long been used to promote flowering in pineapple production. Ethylene-induced flowering is dose dependent, with a critical threshold level of ethylene response factors needed to trigger flowering. The mechanism of ethylene-induced flowering is still unclear. Here, we integrated isoform sequencing (iso-seq), Illumina short-reads sequencing and whole-genome bisulfite sequencing (WGBS) to explore the early changes of transcriptomic and DNA methylation in pineapple following high-concentration ethylene (HE) and low-concentration ethylene (LE) treatment. Iso-seq produced 122,338 transcripts, including 26,893 alternative splicing isoforms, 8,090 novel transcripts and 12,536 candidate long non-coding RNAs. The WGBS results suggested a decrease in CG methylation and increase in CHH methylation following HE treatment. The LE and HE treatments induced drastic changes in transcriptome and DNA methylome, with LE inducing the initial response to flower induction and HE inducing the subsequent response. The dose-dependent induction of FLOWERING LOCUS T-like genes (FTLs) may have contributed to dose-dependent flowering induction in pineapple by ethylene. Alterations in DNA methylation, lncRNAs and multiple genes may be involved in the regulation of FTLs. Our data provided a landscape of the transcriptome and DNA methylome and revealed a candidate network that regulates flowering time in pineapple, which may promote further studies.
Locally Advanced Disease and Pelvic Exenterations
Authors: Kontovounisios Christos , Tekkis Paris 
Published: December 2017

AbstractAdvanced primary and recurrent colorectal cancer can be successfully treated by experienced, dedicated centers delivering good outcomes with low mortality and morbidity. Development and implementation of a comprehensive referral pathway is to be encouraged. Multidisciplinary team management is essential in the management of this complex group of patients and is associated with significantly more complete preoperative evaluation and more accurate provision of patient information, as well as improved access to the most appropriate individualized management plan. A structured selection process can improve outcomes through standardized approaches to service delivery to provide the highest quality of care.
Coronary Artery Disease in Young Females: Current Scenario
Authors: Kher Monica , Sathyanarayan Bysani 
Published: December 2017

Background Despite coronary artery disease (CAD) being the leading cause of morbidity and mortality in females, women still have been underrepresented in clinical trials. We have abundant data for young males with obstructive CAD, but there is scarcity of data for young females.
Objectives To observe the presentation, disease pattern, risk factors, ventricular function, and percutaneous coronary intervention (PCI) efficiency in young females in comparison with young males with obstructive CAD who required PCI.
Material and Methods We conducted a hospital-based retrospective study and analyzed the data of young patients (< 45 years of age) who had undergone PCI over the past 2 years. We observed the demographic profile, clinical findings, and investigative and treatment modalities in these patients.
Results Total 200 young patients underwent PCI for obstructive CAD over a span of 2 years. Among these patients, 42 patients were females. In comparison to males, hypertension (43.7% vs. 69.1%, p = 0.008) was more among females, which was statistically significant. Smoking was predominant in young males than young females. Also, males presented as acute ST-elevation MI, whereas females presented with unstable angina or non–ST-elevation MI (NSTEMI). Multivessel involvement, LV dysfunction, success of PCI, and complication rates were similar in both the groups. Anemia was more predominant in females (< 11 g/dL) than in males (< 13 g/dL). Also, complexity of lesion on angiography (B2 or C type of lesions) was greater in females than males, which was statistically significant (p = 0.02).
Conclusion Diabetes, hypertension, and other metabolic factors play a very important role in the onset of CAD in young women. NSTEMI and complex lesions showed greater predominance in females than in males in our study. However, the success and complication rate of PCI remained the same.
Management of Malocclusion after Maxillofacial Trauma
Authors: Sharma Ashish , Hondorp Brian , Gaiduchik Andrey , Baba Nadim , Thakker Jayini , Inman Jared 
Published: December 2017

AbstractEfficacious management of malocclusion following maxillofacial trauma requires understanding of the interaction between teeth and alveolar bone, facial skeleton, temporomandibular joints, and facial neuromusculature. Success is best achieved with a multidisciplinary approach. This article describes the management of malocclusion after primary repair by highlighting important clinical features and offering guidelines for secondary repair through revision surgical reduction, prosthodontic rehabilitation, orthodontic therapy, restorative dentistry, and orthognathic surgery.