bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: HELENINDERIVATE 1. MITT. BIOLOGISCH AKTIVE DERIVATE DES ISOALANTOLACTONS
Authors: DRJANOWSKA‐NONINSKA L. , TODOROWA‐AVRAMOVA P. , NAJDENOWA E. , LOBUTOWA L. 
Published: March 2016

AbstractHelenin, das hauptsächlich aus den Sesquiterpenlactonen A1anto‐(I) und Isoa.= lantolacton (II) besteht, wird in äthanolischer Lösung mit den sekundären Aminen (III) umgesetzt.
ChemInform Abstract: THE PREPARATION OF STEROIDAL AMIDES PART 1, TRIPHENYLPHOSPHITE METHOD PART 2, IMIDAZOLIDE METHOD AND EEDQ METHOD
Authors: HERZ J. E. , MANTECON R. E. 
Published: March 2016

AbstractLithocholsäure‐3‐formiat (I) liefert nach der Methode von Mitin und Glinzkaya durch Umsetzung mit den Aminen (IIa)‐(IIf) und Triphenylphosphit in Gegenwart von Imidazol in Tetrahydrofuran bei 40°C in 65 ‐ 83%iger Ausbeute die Amide (IIIa)‐(IIIf).
ChemInform Abstract: IMPROVED SOLID‐PHASE SYNTHESIS OF TRYPTOPHAN‐CONTAINING PEPTIDES PART 2, USE OF N(ALPHA)‐T‐BUTYLOXYCARBONYL‐N(I)‐FORMYLTRYPTOPHAN
Authors: OHNO MOTONORI , TSUKAMOTO SADAJI , SATO SHIN‐ICHI , IZUMIYA NOBUO 
Published: March 2016

AbstractDas durch Formylierung von Tryptophan (Trp) erhaltene Ni‐Formyl‐tryptophan [Trp(CHO)] ist gegenüber Oxidation durch HCl in Essigsäure resistenter als Trp.
ChemInform Abstract: NEUE VERFAHREN ZUR ANOMEREN C‐FUNKTIONALISIERUNG, ZUGANG ZU CHEMISCHEN VORLAEUFERN VON C‐NUCLEOSIDEN
Authors: OGAWA T. , PERNET A. G. , HANESSIAN S. 
Published: March 2016

AbstractAus Zuckeracylaten wie (I) erhält man mit Zinntetrachlorid die Salze (II), die mit Trimethylsilylenoläthern wie Trimethylsilyl‐cyclohexenol (III) unter C‐Verknüpfung das Kondensat (IV) geben.
ChemInform Abstract: NUCLEOPHILIC DISPLACEMENT OF CARBOHYDRATE PRIMARY HALIDES WITH LITHIO‐1,3‐DITHIANE
Authors: SEPULCHRE A. M. , VASS G. , GERO S. D. 
Published: March 2016

AbstractAus den beiden 5‐funktionellen Ribofuranosiden (Ia) und (Ib) erhält man mit 2‐Lithio‐1,3‐dithian (II) das Kondensationsprodukt (III), das zum Aldehyd (IV) verseift und dann zum Carbinol (V) reduziert wird.
ChemInform Abstract: C‐GLYCOSYL NUCLEOSIDES PART 2, REACTION OF SUGAR ALDEHYDE WITH ACETYLENIC GRIGNARD REAGENTS
Authors: OGURA H. , OGIWARA M. , ITOH T. , TAKAHASHI H. 
Published: March 2016

AbstractDie Diisopropyliden‐aldehydo‐D‐ribose (I) reagiert mit den Grignard‐Verbindungen (II) in Tetrahydrofuran zu den epimeren Heptin‐Derivaten (III) und (IV).
ChemInform Abstract: CARBOCYCLIC ANALOGS OF 6‐SUBSTITUTED PURINE RIBONUCLEOSIDES AND OF ADENOSINE RIBONUCLEOTIDES
Authors: SHEALEY Y. F. , CLAYTON J. D. 
Published: March 2016

AbstractDas aus dem Diaminopyrimidin (I) durch Cyclisierung mit Orthoameisensäureester (II) in Gegenwart von konzentrierter Salzsäure′ hergestellte Purinderivat (III) wird durch Behandlung mit Aminen, Hydroxylamin und Natriummethylat in die Verbindungen (IV) umgewandelt.
ChemInform Abstract: METALLFREIE DERIVATE DES CORPHIN‐LIGANDSYSTEMS
Authors: MUELLER PETER M. , FAROOQ SALEEM , HARDEGGER BRUNO , SALMOND WILLIAM S. , ESCHENMOSER ALBERT 
Published: March 2016

AbstractAus dem über das bereits beschriebene Verfahren der J od‐enamin‐Thiolactam‐ Kupplung erhältlichen Ni‐Komplex (I) wird durch Behandlung mit K‐tert‐butoxid die Cyanid‐Schutzgruppe entfernt (gute Ausbeute).
ChemInform Abstract: SYNTHETIC ENTRY INTO THE PROSTAGLANDIN C SERIES
Authors: COREY E. J. , MOINET GERARD 
Published: March 2016

AbstractUmsetzung des Lactols (I) mit dem Metallcarbonyl (II) liefert den Komplex (III), der mit dem Phosphoran (IV) in die Säure (V) übergeführt wird.
Nb‐Doped Hematite Nanorods for Efficient Solar Water Splitting: Electronic Structure Evolution versus Morphology Alteration
Authors: Fu Yanming , Dong Chung‐Li , Lee Wan‐Yi , Chen Jie , Guo Penghui , Zhao Liang , Shen Shaohua 
Published: March 2016

AbstractIn this study, Nb‐doped α‐Fe2O3 nanorod photoanodes were prepared via a facile solution‐based process by directly adding NbCl5 in the aqueous solution. The morphology and electronic structure of Nb‐doped α‐Fe2O3 films depended strongly on the dopant concentrations. Compared with the undoped sample, the optimal Nb‐doped α‐Fe2O3 film showed an approximately 4‐fold photocurrent increase under solar light at 1.0 V versus Ag/AgCl, and the incident photon‐to‐current conversion efficiency was increased by 2.5 times, reaching 13.7 % at 350 nm and 1.23 V versus RHE. The enhancement in PEC activity, as induced by moderate Nb doping, was attributed to the increased charge carrier density for promoted charge transfer ability as well as the smaller nanorod diameter for shortened charge transfer distance. However, superfluous Nb dopants would destroy the nanorod structure and greatly reduce the thickness of α‐Fe2O3 films, leading to poor optical absorption and thus decreased photoelectrochemical performance.
Multiphase partitioning and risk assessment of endocrine-disrupting chemicals in the Pearl River, China
Authors: Gong Jian , Huang Youda , Huang Wen , Ran Yong , Chen Diyun 
Published: March 2016

Abstract

Multiphase partitioning of endocrine-disrupting chemicals (EDCs) in the Pearl River (China) were investigated. The colloidal concentrations for 4-tert-octylphenol, 4-nonylphenol, bisphenol A (BPA), and estrone (E1) were in the ranges of 0.2 ng/L to 0.8 ng/L, 23.2 ng/L to 108 ng/L, 2.3 ng/L to 97.6 ng/L, and not detectable (nd) to 0.32 ng/L, respectively; for truly dissolved concentrations, the ranges were 0.5 ng/L to 5.4 ng/L, 39 ng/L to 319 ng/L, 13.7 ng/L to 91.2 ng/L, and nd to 1.2 ng/L, respectively. Positive correlations of EDCs with colloidal organic carbon (COC) were observed. The in situ COC normalized partitioning coefficients (log KCOC) for 4-tert-octylphenol (5.35 ± 0.42), 4-nonylphenol (5.69 ± 0.50), and BPA (5.51 ± 0.77) were within the ranges reported by other studies, whereas they were 1 to 2 orders of magnitude higher than their particulate/truly dissolved phase partition coefficients (log KOCint), revealing much strong sorption of EDCs by aquatic colloids. Moreover, colloid-bound percentages of 4-tert-octylphenol, 4-nonylphenol, and BPA ranged, respectively, from 6.9% to 36.4%, from 16.7% to 63.1%, and from 3.6% to 52.4%; their estimated mass fractions were 0.29 ± 0.21, 0.38 ± 0.26, and 0.39 ± 0.33, respectively. Obviously the colloid-bound fractions are significant. Furthermore, a medium risk of estrogenic effects was estimated from the truly dissolved concentrations of EDCs in the Pearl River, which was lower than the estimated high risk according to the conventionally dissolved concentrations. It is suggested that the presence of colloids be incorporated into future water quality prediction and ecological risk assessment. Environ Toxicol Chem 2016;35:2474–2482. © 2016 SETAC
Docking and subduction of the West Pacific seamounts along the Mariana Trench and their effects
Authors: Zhang Bin , Li Guangxue , Li Sanzhong , Dada Olusegun A. 
Published: March 2016

AbstractThe Mariana Trench is located at the edge of the West Pacific Plate, with a lot of large aseismic ridges lying there. These seamounts significantly affect the trench morphology and topographic change by the continuous subduction associated with NW‐directed Pacific Plate motion. In this article, the topography of the Mariana Trench is analysed by considering the free‐space and Bouguer‐gravity anomalies and the interaction between the seamounts and the plate boundary. All results indicate that following the movement of relatively isolated large‐sized seamounts near the plate boundary to the edge of the Mariana Trench, the impact of the subducting plate on the surrounding area lessens. As a consequence, the trench becomes shallower and jumps towards the seaward edge. Furthermore, a large area of large‐sized seamounts and oceanic rises will incise the subducting plate while approaching the trench axis, promote the subduction processes and increase the trench bathymetries. Shallower bathymetries at the middle section of the Mariana Trench, the discontinuous trench axes and some fickle topographic features in the front of the arc, are mostly caused by the docking or the subduction of the relatively isolated large‐scale seamounts. The docking or the subduction of a large area of seamounts has certain influences on the formation of a deep‐sea trench at the south section. Copyright © 2016 John Wiley & Sons, Ltd.
Effective impervious area for runoff in urban watersheds
Authors: Ebrahimian Ali , Gulliver John S. , Wilson Bruce N. 
Published: March 2016

AbstractEffective impervious area (EIA), or the portion of total impervious area (TIA) that is hydraulically connected to the storm sewer system, is an important parameter in determining actual urban runoff. EIA has implications in watershed hydrology, water quality, environment, and ecosystem services. The overall goal of this study is to evaluate the application of successive weighted least square (WLS) method to urban catchments with different sizes and various hydrologic conditions to determine EIA fraction. Other objectives are to develop insights on the data selection issues, EIA fraction, EIA/TIA ratio, and runoff source area patterns in urban catchments. The successive WLS method is applied to 50 urban catchments with different sizes from less than 1 ha to more than 2000 ha in Minnesota, Wisconsin, Texas, USA as well as Europe, Canada, and Australia. The average, median, and standard deviation of EIA fractions for the 42 catchments with residential land uses are found to be 0.222, 0.200, and 0.113, respectively. These values for the EIA/TIA ratio in the same 42 catchments are 0.50, 0.48, and 0.21, respectively. While the EIA/TIA results indicate the importance of EIA, 95% prediction interval of the mean EIA/TIA is found to be 0.07 to 0.93, which shows that using an average value for this ratio in each land use to determine EIA from TIA in ungauged urban watersheds can be misleading. The successive WLS method was robust and is recommended for determining EIA in gauged urban catchments. Copyright © 2016 John Wiley & Sons, Ltd.
Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts
Authors: Lord Megan S. , Farrugia Brooke L. , Yan Claudia M. Y. , Vassie James A. , Whitelock John M. 
Published: March 2016

AbstractCerium oxide nanoparticles are being widely explored for cell therapies. In this study, nanoceria was functionalized with hyaluronan (HA) using the organosilane linker, 3‐aminopropyltriethoxysilane. HA‐nanoceria was found to be cytocompatible and to reduce intracellular reactive oxygen species in human fibroblasts. The HA‐nanoceria was found to colocalize with CD44 on the surface of the cells and once internalized traffic to the lysosomes, be degraded and induce markers of autophagy. These particles were also effective in reducing the cell surface expression of CD44. Together these data suggest that HA‐nanoceria is a promising drug delivery material to target CD44‐expressing cells through a variety of mechanisms. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1736–1746, 2016.
Going beyond work and family: A longitudinal study on the role of leisure in the work–life interplay
Authors: Knecht Michaela , Wiese Bettina S. , Freund Alexandra M. 
Published: March 2016

SummaryGoing beyond the relation of work and family, the present three‐wave longitudinal study spanning one year assessed different forms of conflict and facilitation between leisure and the life domains work and family and their relation to subjective well‐being. A sample of N = 277 employed men and women reported their perceived conflict and facilitation between leisure, work, and family and subjective well‐being. Results suggest that leisure is a source of facilitation for work and family, and, at the same time, a major recipient of conflict from work and family. Moreover, leisure conflict was negatively correlated and leisure facilitation was positively associated with concurrent subjective well‐being. Both conflict and facilitation between all three life domains remained highly stable over the course of one year. Only few and non‐systematic lagged effects were found, indicating that the variance of the stability of the constructs and their relations over time leave little room for longitudinal predictions. Taken together, the study demonstrates that, similar to work–family relations, conflict and facilitation with the leisure domain are also associated with subjective well‐being and remain highly stable over the course of a year in the lives of young and middle‐aged adults. Copyright © 2016 John Wiley & Sons, Ltd.
Role of myeloid early endothelial progenitor cells in bone formation and osteoclast differentiation in tissue construct based on hydroxyapatite poly(ester‐urethane) scaffolds
Authors: Shi Yang , Wang Fanlu , Tiwari Sanjay , Yesilbas Meran , Steubesand Nadine , Weitkamp Jan‐Tobias , Klüter Tim , Lippross Sebastian , Eglin David , Seekamp Andreas , Fuchs Sabine 
Published: March 2016

ABSTRACTEngineering of a vascularized bone construct is a highly challenging task which needs to take into account the impact of different components on the bone regeneration process. Bone repair influencing factors in such constructs range from the material properties and scaffold design, to the interaction of different cell types contributing to bone formation and remodeling or neovascularization, respectively. In this context, early endothelial progenitor cells (EPC), mononuclear cells isolated from the peripheral blood, express the endothelial marker CD31 but also a series of myeloid markers and have been shown to support the formation of vessel‐like structures. These cells are also characterized by a highly adaptable phenotype influenced by other cells creating an instructive niche. The present study was designed to investigate the impact of EPC on bone formation or remodeling using a co‐culture system of outgrowth endothelial cells, mature endothelial cells isolated from the peripheral blood cell cultures, and mesenchymal stem cells grown on hydroxyapatite poly(ester‐urethane) scaffolds. The formation of vessel‐like structures in these constructs was shown by CLSM and immunohistochemistry and further evaluated by real time RT‐PCR. Osteogenic differentiation in these constructs was investigated by von Kossa, Alizarin Red, and real time PCR. Data indicated that osteogenic differentiation occurred within the constructs after 14 days of culture but without a direct influence by EPC in this process. Finally, although we observed a series of osteoclast related makers in the constructs when EPC were included, no indications for an increased osteoclast‐like activity, which might lead to increased bone resorption, were observed. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1922–1932, 2016.
Lipid production from hemicellulose with Lipomyces starkeyi in a pH regulated fed‐batch cultivation
Authors: Brandenburg Jule , Blomqvist Johanna , Pickova Jana , Bonturi Nemailla , Sandgren Mats , Passoth Volkmar 
Published: March 2016

AbstractThis study investigated lipid production from the hemicellulosic fraction of birch wood by the oleaginous yeast Lipomyces starkeyi. Birch wood chips were thermochemically pretreated by hot water extraction, and the liquid phase, containing 45.1 g/l xylose as the major sugar, 13.1 g/l acetic acid and 4.7 g/l furfural, was used for cultivations of L. starkeyi CBS1807. The hydrolysate strongly inhibited yeast growth; the strain could only grow in medium containing 30% hydrolysate at pH 6. At pH 5, growth stopped already upon the addition of about 10% hydrolysate. In fed‐batch cultures fed with hydrolysate or a model xylose–acetic acid mixture, co‐consumption of xylose and acetic acid was observed, which resulted in a pH increase. This phenomenon was utilized to establish a pH‐stat fed‐batch cultivation in which, after an initial feeding, hydrolysate or model mixture was connected to the pH‐regulation system of the bioreactor. Under these conditions we obtained growth and lipid production in cultures grown on either xylose or glucose during the batch phase. In cultivations fed with model mixture, a maximum lipid content of 60.5% of the cell dry weight (CDW) was obtained; however, not all xylose was consumed. When feeding hydrolysate, growth was promoted and carbon sources were completely consumed, resulting in higher CDW with maximum lipid content of 51.3%. In both cultures the lipid concentration was 8 g/l and a lipid yield of 0.1 g/g carbon source was obtained. Lipid composition was similar in all cultivations, with C18:1 and C16:0 being the most abundant fatty acids. Copyright © 2016 John Wiley & Sons, Ltd.
Massive post‐polypectomy hemorrhage: Successful tulip‐bundle technique with endoloop for hemostasis
Authors: Yen Hsu‐Heng , Yang Chia‐Wei , Wu Shun‐Sheng , Soon Maw‐Soan 
Published: March 2016

SummaryColonoscopic polypectomy is a common procedure for removing colonic polyps to prevent subsequent development of colon cancer. Hemorrhage is the most common complication following polypectomy, with a reported rate of 0.3% to 6.0%. The risk increases to 12.5% when the size of the polyp stalk exceeds 1 cm. The most commonly used endoscopic preventive techniques, such as injection therapy, prophylactic use of endoclip, or endoloop, were found to decrease the rate of post‐polypectomy hemorrhage, and repeated use of these techniques is useful for controlling bleeding. Here, we reported a case of a 65‐year‐old man with refractory post‐polypectomy hemorrhage for a 2‐cm adenomatous polyp. Application of an endoloop using the tulip‐bundle technique achieved successful hemostasis. To our knowledge, this is the first report of this technique being used to treat refractory acute post‐polypectomy hemorrhage.
Burnout en médicos internos de pregrado del Hospital General de México Dr. Eduardo Liceaga
Authors: Athié Gutiérrez César , Cardiel Marmolejo Lino Eduardo , Camacho Aguilera Jaime , Mucientes Avellaneda Víctor Manuel , Terronez Girón Andrea Del Mar 
Published: March 2016

Introducción: El síndrome de burnout, entendido como una reacción afectiva en respuesta al estrés laboral crónico, se integra con 3 ejes fundamentales: desgaste emocional, despersonalización y falta de realización personal. Repercute significativamente tanto a instituciones como a empleados, particularmente los relacionados con la medicina.
Jornadas laborales extenuantes, alta exigencia académica y demandas emocionales son constantes durante el internado médico de pregrado, siendo los médicos internos de pregrado (MIP) vulnerables para desarrollar burnout. Por esto es conveniente realizar estudios para identificar dicho síndrome y sus componentes, implementar medidas preventivas y mejorar las condiciones laborales, garantizando una mejor calidad de servicio al paciente.

Objetivo: Determinar la prevalencia del síndrome de burnout en los MIP del Hospital General de México Dr. Eduardo Liceaga y establecer asociaciones con factores de riesgo.

Método: Se realizó un estudio transversal, observacional y descriptivo a 141 MIP del Hospital General de México Dr. Eduardo Liceaga a través de la encuesta de Maslach Burnout Inventory para conocer la prevalencia de burnout y analizar su correlación con factores asociados mediante la prueba estadística Rho de Spearman.

Resultados: El total de la población presentó algún grado de desgaste laboral y el 16% cumplió con criterios de burnout. Se encontró relación estadisticamente significativa entre el burnout y el tiempo de traslado (p - —0.203, p 0.016), asi como la universidad de procedencia (p - -0.184, 0.029).

Conclusiones: En respuesta a los resultados obtenidos se sugiere realizar una valoración al inicio del internado para identificar población en riesgo, modificación en el rol de la rotación, otorgar la posguardia en servicios de alta demanda y apoyo psicológico en caso de ser necesario.
Intraosseous schwannoma localized in the anterior mandible with multilocular radiolucency: A case report
Authors: Kawasaki Yasuhiro , Kobashi Hironobu , Ishii Syouichirou , Yakushijib Noboru 
Published: March 2016

AbstractIntraosseous schwannoma in the oral and maxillofacial regions is rare. It arises most commonly in the posterior region of the mandible due to the presence of the inferior alveolar nerve. There have been only seven reported cases of intraosseous schwannoma localized in the anterior region of the mandible, all of which involved unilocular radiolucency. In this study, we report the rare case of an intraosseous schwannoma localized in the anterior mandible with multilocular radiolucency. The radiographic and clinical features of this case may be helpful for providing a correct diagnosis and treatment in the future.
Partial duplication of theCRYBB1-CRYBA4locus is associated with autosomal dominant congenital cataract
Authors: Siggs Owen M. , Javadiyan Shari , Sharma Shiwani , Souzeau Emmanuelle , Lower Karen M. , Taranath Deepa A. , Black Jo , Pater John , Willoughby John G. , Burdon Kathryn P. , Craig Jamie E. 
Published: March 2016

AbstractCongenital cataract is a rare but severe paediatric visual impediment, often caused by variants in one of several crystallin genes that produce the bulk of structural proteins in lens. Here we describe a pedigree with autosomal dominant isolated congenital cataract and linkage to the crystallin gene cluster on chromosome 22. No rare single nucleotide variants or short indels were identified by whole-exome sequencing, yet copy number variant analysis revealed a duplication spanning both CRYBB1 and CRYBA4. While the CRYBA4 duplication was complete, the CRYBB1 duplication was not, with the duplicated CRYBB1 product predicted to create a gain of function allele. This association suggests a new genetic mechanism for the development of isolated congenital cataract.Grant informationSupported by the National Health and Medical Research CouncilConflict of interestthe authors declare no conflict of interest.
Ductus venosus Doppler in the assessment of fetal cardiovascular health: an updated practical approach
Authors: Seravalli Viola , Miller Jena L. , Block‐Abraham Dana , Baschat Ahmet A. 
Published: March 2016

AbstractThe ductus venosus has a central role in the distribution of highly oxygenated umbilical venous blood to the heart. Its waveform is related to the pressure‐volume changes in the cardiac atria and it is therefore important in the monitoring of any fetal condition that may affect forward cardiac function. The cardiovascular parameters that can influence forward cardiac function include afterload, myocardial performance and preload. Decreased forward flow during atrial systole (a‐wave) is the most sensitive and ubiquitous finding when any of these parameters is affected. In contrast, decreased forward velocities during end‐systolic relaxation (v‐wave) are more specifically related to myocardial performance. The ductus venosus pulsatility index alone does not accurately reflect cardiac function, and in cases of suspected fetal cardiac dysfunction, echocardiography is required to identify the underlying mechanism. The role of ductus venosus Doppler in the assessment of fetal growth restriction, supraventricular tachycardia, fetal hydrops, complicated monochorionic twins and congenital heart disease is discussed with these considerations in mind.