bluuebunny/crossref_metadata_2025_split huggingface dataset:
Portuguese Validation of the Perfectionism Self Presentation Scale
Authors: Pereira A.T. , Marques C. , Martins M.J. , Araújo A.I. , Cabaços C. , Brito M.J. , Mendonça L. , Macedo A. 
Published: June 2017

IntroductionPerfectionist Self Presentation represents the interpersonal expression of perfectionism wherein individuals engage in strategies that promote their supposed perfection and conceal their perceived imperfections (Hewitt et al., 2003).ObjectiveTo investigate the psychometric properties of the Portuguese version of the Perfectionist Self Presentation Scale/PSPS.MethodsTwo hundred and eighty-six university students (69.2% females; mean age = 21.09 ± 2.133) answered the Portuguese preliminary version of the PSPS, and the Portuguese validated versions of: Multidimensional Perfectionism Scales, Dirty Dozen and Depression Anxiety and Stress Scale. To study the temporal stability, 30 participants (66.7% females) answered the PSPS again after six weeks. SPSS and MPlus were used.ResultsThe PSPS Cronbach alpha was .91. The test-retest correlation coefficient was .66 (P < .01). Exploratory factor analysis resulted in a three dimension's model (χ2 = 1974.015, P < .01; RMSEA = 0.079, 90% CI = 0.069–0.088; CFI = 0.869; TLI = 0.812; SRMR = 0.046). The three factors presented good internal consistency: F1 Perfectionist self-presentation (PSPS; a = .85), F2 Interpersonal Concern over mistakes (ICM; a = .79); F3 Perfectionist image (PI; a = .70).PSP and ICM (and PI with fewer significant coefficients and lower magnitudes) were moderately to highly correlate with personal standards, concern over mistakes, doubts about action, self-oriented perfectionism and social prescribed perfectionism (≥ .40). Correlations with narcissism and machiavellianism, anxiety and stress were moderate (r = .30) (all P < .01).ConclusionsThe Portuguese version of PSPS has good reliability and validity, with the factorial model presenting an acceptable fit (Hair et al., 2004). It could be very useful both in clinical and research contexts, namely in an ongoing research project on the relationship between perfectionism and interpersonal functioning.Disclosure of interestThe authors have not supplied their declaration of competing interest.
The Factor Structure of the Portuguese Version of the Personality Inventory for DSM-5 (PID-5)
Authors: Pires R. , Sousa Ferreira A. , Gonçalves B. 
Published: June 2017

IntroductionThe DSM-5 Section III proposes a dimensional-categorical model of conceptualizing personality and its disorders, which includes assessment of impairments in personality functioning (criterion A) and maladaptive personality traits (criterion B). The Personality Inventory for DSM-5 (PID-5) is a self-report, composed of 220 items, organized into 25 facets nested in five domains of personality differences, and was developed to operationalize criterion B.ObjectivesThis study explores the factor structure of the Portuguese adaptation of the PID-5.AimsThe five-factor structure that has emerged in previous studies with the PID-5 (cf. Krueger & Markon) is expected to be replicated in the current study.MethodsExploratory factor analyses with varimax oblique rotation were conducted on a sample of Portuguese adults from the general population (n = 379, Mage = 31.49, SD = 14.16, 25.3% males, 74.7% females).ResultsA six factor structure was retained in which the first 5 factors resemble the PID-5 domains. The model showed good fit indices (KMO = 0.897). The total explained variance was 68.25%. All the facets but four had primary loadings on the expected factor.ConclusionsThe similarity of results across studies and nationalities contributes to the validation of the Portuguese translation of the PID-5 and highlights the structural resemblance among the DSM-5 model and the five factor model (FFM) and the personality psychopathology-five model (PSY-5), drawing attention to the relevance of these models for the diagnosis of Personality Disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Measuring Motivation in Patients with Schizophrenia with Apathy Evaluation Scale (AES). Pilot Study of the Russian Version
Authors: Minyaycheva M. , Kiselnikova K. , Movina L. , Gladyshev I. , Papsuev O. 
Published: June 2017

IntroductionReduction of mental productivity and motivation in patients with schizophrenia is one of the core features of negative symptoms of schizophrenia spectrum disorders. Lack of motivation affects social functioning and outcomes, reduces effects of psychosocial treatment and rehabilitation.ObjectivesTo research AES abilities in measuring motivation in patients with schizophrenia spectrum disorders. The aim of the study was to investigate correlations of Russian translation of clinician-rated and self-rated versions with PANSS amotivation subscale and negative subscale items.MethodsFifty patients with schizophrenia spectrum disorders were recruited to participate in the study and were assessed with PANSS, AES-C and AES-S by trained raters. Only patients in “stabilized” state that met inclusion criteria of PANSS total score ≤ 80 points were eligible for consecutive AES assessment.ResultsOverall, moderate positive correlations were established between AES-C and PANSS amotivation subscale N2 and N4 items, N6 item and total PANSS negative subscale. No significant correlations with G16 item were registered. AES-C and AES-S versions also showed positive Spearman correlations (r = 0.43; P < 0.05), while no correlations between AES-S and amotivation PANSS items were registered.DiscussionModerately strong correlations between AES-C and PANSS N2, N4 and N6 items show feasibility of AES-C version in terms of measuring motivation in patients with schizophrenia spectrum disorders. Results of AES-S analysis demonstrate certain problems in patients’ abilities in self-assessing motivation. Patients with prevailing paranoid syndrome showed poorer results in AES-S scores.ConclusionsAES-C is a sensitive psychometric tool with good properties in measuring amotivation in patients with schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Assessment of Suicide-related Knowledge and Skills in a Sample of Health Professionals and Students
Authors: Pompili M. , Erbuto D. , Innamorati M. , Migliorati M. , Girardi P. 
Published: June 2017

ObjectiveAssessment of suicide risk is of paramount importance for proper prevention.AimsTo examine the association between gatekeeper training and suicide-related knowledge among a diverse set of health care workers (psychiatrists, nurses, psychologists, and educators) and students enrolled in medical and psychological schools who took part in the world suicide prevention day 2015 conference.MethodAmong 223 participants who completed the assessment, 204 provided complete data for analyses. Participants were administered the applied suicide intervention skills training (ASIST), a 13-item survey questionnaire to assess participants’ knowledge about suicidal behavior and comfort dealing with suicidal clients. There were 62 psychiatrists; 23 nurses, 51 psychologists, 11 educators, and 57 university students.ResultsAmong participants, 57.1% of the sample had experiences of suicide a patient (students were excluded from these analyses). Those who reported a suicide among patients (compared with others) less frequently answered that suicide risk is more alarming in older adults than youths. They also less frequently disagreed with questions asking if they had the training to deal with suicidal patients. Students more frequently answered correctly on the association between depression and suicide risk, and less frequently chose the correct answer on the seriousness of suicide intent in borderline personality disorder. Students also more frequently disagreed with questions asking on their suicide assessment skill.ConclusionsOur study highlights that differences exist when it comes to knowledge and skills related to suicide risk assessment both among health professionals and students. Our results also indicate that suicide awareness among these groups should be promoted.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Family-based Whole Exome Sequencing of Autism Spectrum Disorder Reveals Novel De Novo Variants in Korean Population
Authors: Yoo H. , Kim S.A. , Park M. , Kim J. , Lim W.J. , Noh D.H. , Han D.W. , Shin C. , Kim N. 
Published: June 2017

ObjectivesThe objective of this family-based whole exome sequencing (WES) is to examine genetic variants of autism spectrum disorder (ASD) in Korean population.MethodsThe probands with ASD and their biological parents were recruited in this study. We ascertained diagnosis based on DSM-5™ criteria, using Autism Diagnostic Observation Schedule and Autism Diagnostic Interview–Revised. We selected probands with typical phenotypes of ASD both in social interaction/communication and repetitive behaviour/limited interest domains, with intellectual disability (IQ < 70), for attaining homogeneity of the phenotypes. First, we performed WES minimum 50× for 13 probands and high-coverage pooled sequencing for their parents. We performed additional WES for 38 trio families, at least 100× depth. De novo mutations were confirmed by Sanger sequencing. All the sequence reads were mapped onto the human reference genome (hg19 without Y chromosome). Bioinformatics analyses were performed by BWA-MEM, Picard, GATK, and snpEff for variant annotation. We selected de novo mutation candidates from probands, which are neither detected in two pooled samples nor both parents.ResultsFifty-one subjects with ASD (5 females, 40∼175 months, mean IQ 42) and their families were included in this study. We discovered 109 de novo variants from 46 families. Twenty-nine variants are expected to be amino acid changing, potentially causing deleterious effects. We assume CELSR3, MYH1, ATXN1, IDUA, NFKB1, and C4A/C4B may have adverse effect on central nerve system.ConclusionsWe observed novel de novo variants which are assumed to contribute to development of ASD with typical phenotypes and low intelligence in WES study.Disclosure of interestThis work has been supported by Healthcare Technology R&D project (No: A120029) by Ministry of Health and Welfare, Republic of Korea.
Prevalence of metabolic syndrome and of symptoms of anxiety and depression in patients undergoing colonoscopy
Authors: Marchi M. , Alboni S. , Fabbrizi A. , Feltri L. , Galli G. , Guicciardi A. , Mancini S. , Mattei G. , Minarini A. , Perrone D. , Rioli G. , Roncucci L. , Sena P. , Ferrari S. 
Published: June 2017

IntroductionMetabolic syndrome (MetS) is defined by metabolic and cardio-vascular impairments and is frequently associated with anxiety and depressive disorders. Both MetS and anxiety-depressive syndromes feature similar systemic inflammatory alterations. Inflammation of the large bowel is also a key factor for the development of colorectal cancer (CRC).ObjectiveTo measure the prevalence of MetS and symptoms of anxiety and depression among patients undergoing colonoscopy.MethodsCross-sectional study. Patients undergoing colonoscopy aged 40 or more, with negative history for neoplasia or inflammatory bowel disease, were enrolled. Data collected: colonoscopy outcome, presence/absence of MetS (IDF and ATP III criteria), presence/absence of depressive and anxiety symptoms assessed with HADS.ResultsThe sample was made up of 53 patients (female 24, 45.3%). Mean age was 60.66 ± 9.08. At least one adenoma was found to 23 patients (43.3%). Prevalence of MetS ranged from 34% to 36% (ATP III and IDF criteria, respectively). Prevalence of depressive and anxiety symptoms was 20% and 33%, respectively.ConclusionPrevalence of MetS, anxiety and depressive symptoms among patients undergoing colonoscopy was higher than in the general population.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Hope, self-stigma, personality traits and quality of life in patients with psychotic disorders
Authors: Vrbova K. , Prasko J. , Latalova K. , Kamaradova D. , Ociskova M. , Marackova M. , Holubova M. , Slepecky M. 
Published: June 2017

IntroductionRecently, as a result of an increased emphasis on patients’ needs, the awareness on the quality of life has been engaged into account in the exploration of schizophrenia.ObjectivesThe aim of the study was to explore the relations between hope, self-stigma, personality traits and quality of life in patients with schizophrenia spectrum disorder.MethodsFifty-two stabilized outpatients with schizophrenia spectrum disorders participated in cross-sectional study. The psychiatrist assessed each patient with Mini International Neuropsychiatric Interview and Clinical Global Impression-Severity. The patients completed Quality of Life Satisfaction and Enjoyment Questionnaire, Internalized Stigma of Mental Illness Scale, Temperament and Character Inventory, Adult Dispositional Hope Scale, Drug Attitude Inventory, Liebowitz Social Anxiety Scale, Beck Depression Inventory – II, and Beck Anxiety Inventory.ResultsThe quality of life was significantly higher in employed patients, and individuals with higher hope, self-directedness, and persistence. The quality of life was lower among the patients with higher number of hospitalizations, those with higher severity of the disorder and individuals who were taking more medication. The patients with more pronounced symptoms of depression, anxiety, and social anxiety had a lower quality of life. Finally, the quality of life was lower among the individuals with higher harm avoidance, and self-stigmatization.ConclusionsDetection of the quality of life in the context of personality traits, hope, self-stigma and demographical and clinical factors may be an important part of the treatment of patients with schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Enhancing the DHA content in milk from dairy cows by feeding ALL-G-RICH™
Authors: Moran C. A. , Morlacchini M. , Fusconi G. 
Published: June 2017

SummaryThe objective of this study was to evaluate the effect of the dietary inclusion of 6 g/kg dry matter intake of an unextractedAurantiochytrium limacinumalgae (AURA) in mid-lactation Italian Friesian cows under commercial conditions on milk yield, milk composition and docosahexaenoic acid (DHA) content. Cows were allocated to two groups (n = 18; 108.2 ± 66.1 and 104.4 ± 54.6 days in milk, control and treated groups, respectively). Feeding AURA for 84 d had no effect on dry matter intake, body condition score or weight gain, but did improve milk yield by 1.9 kg/cow/d (+5.4%; P < 0.1) over the course of the experiment. Milk fat concentration declined by 12% (P < 0.0001) without any significant change in 4% fat corrected milk, protein or lactose. Supplementing AURA for 12 weeks substantially altered the fatty acid profile of milk compared with milk from CON-fed cows such that the proportion of unsaturated fatty acids increased, omega-3 fatty acid content increased by 73.1% (P < 0.0001) and was accompanied by a favourable increase in the omega-3:6 fatty acid ratio by 75.0% (P < 0.0001). The AURA supplement, during day 7–84, increased the DHA concentration to 0.37 g /100 g milk total fatty acids (P < 0.0001) with a mean transfer efficiency of 18.1% from feed to milk. Together these results indicated that supplementing a dairy cow diet with DHA-rich microalgae is a feasible and efficient means for creating DHA-enriched milk for human consumption.
Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer
Authors: Wang Bi-Dar , Ceniccola Kristin , Hwang SuJin , Andrawis Ramez , Horvath Anelia , Freedman Jennifer A. , Olender Jacqueline , Knapp Stefan , Ching Travers , Garmire Lana , Patel Vyomesh , Garcia-Blanco Mariano A. , Patierno Steven R. , Lee Norman H. 
Published: June 2017

AbstractClinical challenges exist in reducing prostate cancer (PCa) disparities. The RNA splicing landscape of PCa across racial populations has not been fully explored as a potential molecular mechanism contributing to race-related tumour aggressiveness. Here, we identify novel genome-wide, race-specific RNA splicing events as critical drivers of PCa aggressiveness and therapeutic resistance in African American (AA) men. AA-enriched splice variants ofPIK3CD,FGFR3,TSC2andRASGRP2contribute to greater oncogenic potential compared with corresponding European American (EA)-expressing variants. Ectopic overexpression of the newly cloned AA-enriched variant,PIK3CD-S, in EA PCa cell lines enhances AKT/mTOR signalling and increases proliferative and invasive capacityin vitroand confers resistance to selective PI3Kδ inhibitor, CAL-101 (idelalisib), in mouse xenograft models. HighPIK3CD-Sexpression in PCa specimens associates with poor survival. These results highlight the potential of RNA splice variants to serve as novel biomarkers and molecular targets for developmental therapeutics in aggressive PCa.
Combined Magnetomotive ultrasound, PET/CT, and MR imaging of 68Ga-labelled superparamagnetic iron oxide nanoparticles in rat sentinel lymph nodes in vivo
Authors: Evertsson Maria , Kjellman Pontus , Cinthio Magnus , Andersson Roger , Tran Thuy A , in’t Zandt Rene , Grafström Gustav , Toftevall Hanna , Fredriksson Sarah , Ingvar Christian , Strand Sven-Erik , Jansson Tomas 
Published: June 2017

AbstractCurrent methods for intra-surgical guidance to localize metastases at cancer surgery are based on radioactive tracers that cause logistical challenges. We propose the use of a novel ultrasound-based method, magnetomotive ultrasound (MMUS) imaging that employ a nanoparticle-based contrast agent that also may be used for pre-operative PET/MRI imaging. Since MMUS is radiation free, this eliminates the dependence between pre- and intra-operative imaging and the radiation exposure for the surgical staff. This study investigates a hypothetical clinical scenario of pre-operative PET imaging, combined with intra-operative MMUS imaging, implemented in a sentinel lymph node (SLN) rat model. At one-hour post injection of 68Ga-labelled magnetic nanoparticles, six animals were imaged with combined PET/CT. After two or four days, the same animals were imaged with MMUS. In addition, ex-vivo MRI was used to evaluate the amount of nanoparticles in each single SLN. All SLNs were detectable by PET. Four out of six SLNs could be detected with MMUS, and for these MMUS and MRI measurements were in close agreement. The MRI measurements revealed that the two SLNs undetectable with MMUS contained the lowest nanoparticle concentrations. This study shows that MMUS can complement standard pre-operative imaging by providing bedside real-time images with high spatial resolution.
Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways
Authors: Mantawy Eman M. , Esmat Ahmed , El-Bakly Wesam M. , Salah ElDin Rania A. , El-Demerdash Ebtehal 
Published: June 2017

AbstractDoxorubicin (DOX) is the mainstay chemotherapeutic agent against a variety of human neoplasmas. However, its clinical utility is limited by its marked cardiotoxicity. Chrysin, is a natural flavone which possesses antioxidant, anti-inflammatory and anti-cancer properties. The current study aimed to investigate the potential protective effect of chrysin against DOX-induced chronic cardiotoxicity and the underlying molecular mechanisms. Male Sprague-Dawley rats were treated with either DOX (5 mg/kg, once a week) and/or chrysin (50 mg/kg, four times a week) for four weeks. Chrysin prevented DOX-induced cardiomyopathy which was evident by conduction abnormalities, elevated serum CKMB and LDH and histopathological changes. Chrysin also ameliorated DOX-induced oxidative stress by decreasing lipid peroxidation and upregulating the antioxidant enzymes. Moreover, chrysin attenuated DOX-induced apoptosis via decreasing expression of p53, Bax, Puma, Noxa, cytochrome c and caspase-3 while increasing expression of Bcl-2. DOX induced activation of MAPK; p38 and JNK and increased expression of NF-κB. Meanwhile, DOX suppressed AKT pathway via decreasing expression of its upstream activator VEGF and increasing expression of PTEN. Conversely, chrysin effectively neutralised all these effects. Collectively, these findings indicate that chrysin effectively protected against DOX-induced cardiomyopathy via suppressing oxidative stress, p53-dependent apoptotic pathway, MAPK and NF-κB pathways while augmenting the VEGF/AKT pathway.
Detection of EGFR mutation in plasma using multiplex allele-specific PCR (MAS-PCR) and surface enhanced Raman spectroscopy
Authors: Li Xiaozhou , Yang Tianyue , Li Caesar Siqi , Wang Deli , Song Youtao , Jin Lili 
Published: June 2017

AbstractIn this study, surface enhanced Raman spectroscopy (SERS) in combination with multiplexed polymerase chain reaction (PCR) was utilized to detect mutations of exons 19 and 21 of the epidermal growth factor receptor (EGFR) gene. Through the use of multiplexed PCR, the two mutation types were amplified in a single reaction. SERS was used on the PCR products to detect mutations. DNA mixtures with increasing mutation percentages showed good linear relationship between mutation rates and peak height. Then, this PCR-SERS method was used on the plasma of 48 patients with non-small cell lung cancer (NSCLC) to detect EGFR mutations. Analysis of variance (ANOVA) and receiver operating characteristic (ROC) analysis revealed that the peak height ratios were significant for identifying different mutation types. The specificity, sensitivity and accuracy obtained were all 100%. The proposed method was then validated through comparison with high resolution melting (HRM) and showed high concordance with HRM (Pearson correlation is 0.92). Finally, logistic regression was performed on EGFR mutation status and the clinical features of the 48 patients. Our study indicates that PCR-SERS is an effective, noninvasive, and economical method for the detection and monitoring of EGFR mutations in the plasma of patients with NSCLC.
Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy
Authors: Tan Xia , Chen Guochun , Liu Yu , Zhou Letian , He Liyu , Liu Di , Liu Yexin , Zhang Fan , Li Huiqiong , Liu Hong 
Published: June 2017

AbstractRenal biopsy has been widely recommended in clinic to determine the histological patterns of kidney disease. To prevent bleeding complications, patients should routinely stop anticoagulants prior to renal biopsy. However, patients with kidney disease are susceptible to thromboembolisms, particularly in those with severe hypoalbuminemia. This study was designed to investigate the application of serum D-dimer as a predictor for thrombotic events after renal biopsy. 400 consecutive native renal biopsies were prospectively included in this 2-month follow-up study. The overall incidence of bleeding and thrombotic complication is 4%, including hematuria or large perinephric hematoma (2.5%, n = 10) and thrombotic complication (1.5%, n = 6). Compared to low serum D-dimer (<2.00 μg/ml), subjects in the group of high serum D-dimer (≥2.00 μg/ml) were more incline to develop thrombotic complications (9.1% versus 0.3%; RR, 30.33; p < 0.001). D-dimer correlated positively with age (rs = 0.258, P < 0.001). Inverse correlations were found for albumin (rs = −0.339, P < 0.001). Taken together, patients with high serum D-dimer carry an increased risk of thrombotic complications after renal biopsy. Our findings suggest that serum D-dimer can serve as a potential predictor for thrombotic events in patients with kidney disease. Further cautions should be given to these subjects.