bluuebunny/crossref_metadata_2025_split huggingface dataset:
Who was Dr. William C. Baum?
Authors: Ladd Mitchell R. , Zeiger Martha A. 
Published: January 2018

AbstractThe first discovery of primary hyperaldosteronism secondary to an aldosterone‐secreting adrenal adenoma has been credited solely to Dr. Jerome Conn, an endocrinologist at the University of Michigan and for whom, Conn syndrome was named. Dr. William Baum, a urologist at the University of Michigan, however, was instrumental in the appropriate operation and historical aldosteronoma resection. Despite Dr. Baum’s important role in this discovery, he was never included as an author in any of the subsequent papers describing Conn syndrome and, few today would recognize his name. So, who was Dr. Baum and what happened? This historical article aims to revisit the history surrounding the discovery of aldosteronoma as a cause of Conn’s syndrome and to catalog the life and involvement of Dr. William C. Baum in that discovery.
Immobilization of Methylosinus trichosporium OB3b for methanol production
Authors: Taylor Anne , Molzahn Paige , Bushnell Tanner , Cheney Clint , LaJeunesse Monique , Azizian Mohamad , Semprini Lewis 
Published: January 2018

Abstract
Due to the natural gas boom in North America, there is renewed interest in the production of other chemical products from methane. We investigated the feasibility of immobilizing the obligate methanotrophic bacterium Methylosinus trichosporium OB3b in alginate beads, and selectively inactivating methanol dehydrogenase (MDH) with cyclopropane to produce methanol. In batch cultures and in semi-continuous flow columns, the exposure of alginate-immobilized cells to cyclopropane or cyclopropanol resulted in the loss of the majority of MDH activity (&gt; 80%), allowing methanol to accumulate to significant concentrations while retaining all of M. trichosporium OB3b’s methane monooxygenase capacity. Thereafter, the efficiency of methanol production fell due to recovery of most of the MDH activity; however, subsequent inhibition periods resulted in renewed methanol production efficiency, and immobilized cells retained methane-oxidizing activity for at least 14 days.
Biochemical changes and clinical outcomes in 34 patients with classic galactosemia
Authors: Yuzyuk Tatiana , Viau Krista , Andrews Ashley , Pasquali Marzia , Longo Nicola 
Published: January 2018

AbstractImpaired activity of galactose‐1‐phosphate uridyltransferase (GALT) causes galactosemia, an autosomal recessive disorder of galactose metabolism. Early initiation of a galactose‐restricted diet can prevent or resolve neonatal complications. Despite therapy, patients often experience long‐term complications including speech impairment, learning disabilities, and premature ovarian insufficiency in females. This study evaluates clinical outcomes in 34 galactosemia patients with markedly reduced GALT activity and compares outcomes between patients with different levels of mean galactose‐1‐phosphate in red blood cells (GAL1P) using logistic regression: group 1 (n = 13) GAL1P ≤1.7 mg/dL vs. group 2 (n = 21) GAL1P ≥ 2 mg/dL. Acute symptoms at birth were comparable between groups (p = 0.30) with approximately 50% of patients presenting with jaundice, liver failure, and failure‐to‐thrive. However, group 2 patients had significantly higher prevalence of negative long‐term outcomes compared to group 1 patients (p = 0.01). Only one of 11 patients >3 yo in group 1 developed neurological and severe behavioral problems of unclear etiology. In contrast, 17 of 20 patients >3 yo in group 2 presented with one or more long‐term complications associated with galactosemia. The majority of females ≥15 yo in this group also had impaired ovarian function with markedly reduced levels of anti‐Müllerian hormone. These findings suggest that galactosemia patients with higher GAL1P levels are more likely to have negative long‐term outcome. Therefore, evaluation of GAL1P levels on a galactose‐restricted diet might be helpful in providing a prognosis for galactosemia patients with rare or novel genotypes whose clinical presentations are not well known.
Seismic Moment Release Data in Earthquake Catalogue: Application of Hurst Statistics in Delineating Temporal Clustering and Seismic Vulnerability
Authors: Mukhopadhyay Basab , Sengupta Diptansu 
Published: January 2018

ABSTRACT
Sequential cumulative moment release data of macro-earthquakes (Mw≥4.3) of seventeen seismic zones (A to Q) belonging to NE-Himalaya, Burmese-Andaman arc and West-Sunda arc are analysed by Hurst analysis, a non-parametric statistical procedure to identify clustering of low and high values in a time series. The moment release in a zone occurs in alternate positive, negative and positive sloping segments forming a wave like pattern with intervening small horizontal segment. The negative sloping segments indicate decelerated moment release pattern or temporal slackening of elastic strain release with high b–value (&gt;0.95). The horizontal segment indicates temporal clustering of moderate magnitude events/seismic moments with moderate b-values (0.8–0.95). The positive segment is characterised by accelerated moment release within a short span of time indicating temporal clustering of larger magnitude earthquakes/seismic moments and exhibit lowest b–value (&lt;0.7). All zones attest moderate to high Hurst K values, range 0.7-0.86. The pattern in Hurst plots, specially a reversal of trend after prolong negative slope is used for earthquake prognostication in the seismic zones. Our analysis shows that most of the zones register a notable reversal of Hurst clustering trend after a prolonged negative slope which is accompanied by a major earthquake near its end. However, South Burma region (Zone-I) and Tripura fold belt and Bangladesh Plain (Zone-K) do not show any moderate or large shock around the end of the negative sloping trend in Hurst plot. Hence, these two zones can be considered more prone to produce moderate to larger earthquakes in future.
Structural Data Extraction from Stereographic or Equal Area Projections using Image Processing
Authors: Singhal Vaibhav , Misra Surajit , Gupta Saibal 
Published: January 2018

ABSTRACT
Structural orientation data from the field are commonly represented on stereographic or equal area projections, and the raw data are usually not accessible to other workers for integration into larger datasets or comparative study. We have developed a technique for retrieving raw planar structural data from the above projection types using image analysis techniques. The principle involves two steps: (i) conversion of the foliation pole plots in the image into Cartesian coordinates, and (ii) inversion of the data so-obtained into a geographic reference frame. The process involves either scanning of the target projection, or cropping of the projection figure from a pdf file using image processing software, followed by tracing of the data points and generation of an image file that can be subsequently input into a MATLAB supported program, “StrucExtract”. The results from the program are displayed in the form of dips and dip directions. The program has been tested with synthetic and natural examples, and may be invaluable for retrieval of structural data from older structural literature.
Lithium Enrichment and Isotopic Variation in Minerals from Peridotite Xenoliths from Northwestern Ethiopian Plateau
Authors: Alemayehu Melesse , Zhang Hong-Fu , Sakyi Patrick Asamoah , Haji Muhammed 
Published: January 2018

ABSTRACT
We report Lithium (Li) concentrations and isotopic compositions for co-existing olivine, orthopyroxene (opx), and clinopyroxene (cpx) mineral separates from depleted and metasomatised peridotite xenoliths hosted by basaltic lavas from northwestern Ethiopian plateau (Gundeweyn area). The peridotites contain five lherzolites and one harzburgite and are variably depleted and enriched in LREE relative to HREE. In both depleted and enriched lherzolites, Li is preferentially incorporated into olivine (2.4-3.3 ppm) compared to opx (1.4-2.1 ppm) and cpx (1.4-2.0 ppm) whereas the Li contents of olivines (5.4 ppm) from an enriched harzburgiteare higher than those of lherzolites. Olivines from the samples show higher Li abundances than normal mantle olivines (1.6-1.9 ppm) indicating the occurrence of Li enrichments through melt-preroditite interaction. The average δ7 Li values range from +2.2 to +6.0‰ in olivine, from -0.1 to +2.0‰ in opx and from -4.4 to -0.9‰ in cpx from the lherzolites. The Li isotopic composition (3.5‰) of olivines from harzburgite fall within the range of olivine from lherzolites but the opxs show low in δ7Li (-2.0‰). Overall Li isotopic compositions of olivines from the peridotites fall within the range of normal mantle olivine, δ7Li values of ∼+4±2‰ within uncertainty, reflecting metasomatism (enrichment) of the peridotites by isotopically heavy Li-rich asthenospheric melt. Li isotope zonation is also observed in most peridotite minerals. Majority of olivine grains display isotopically heavy cores and light rims and the reverse case is observed for some olivine grains. Orthopyroxene and clinopyroxene grains show irregular distribution in δ7Li. These features of Li isotopic compositions within and between grains in the samples reflect the effect of diffusion-driven isotopic fractionation during melt-peridotite interaction and cooling processes.
P11 promoter methylation predicts the antidepressant effect of electroconvulsive therapy
Authors: Neyazi Alexandra , Theilmann Wiebke , Brandt Claudia , Rantamäki Tomi , Matsui Nobuaki , Rhein Mathias , Kornhuber Johannes , Bajbouj Malek , Sperling Wolfgang , Bleich Stefan , Frieling Helge , Löscher Wolfgang 
Published: January 2018

AbstractAlthough electroconvulsive therapy (ECT) is among the most effective treatment options for pharmacoresistant major depressive disorder (MDD), some patients still remain refractory to standard ECT practise. Thus, there is a need for markers reliably predicting ECT non/response. In our study, we have taken a novel translational approach for discovering potential biomarkers for the prediction of ECT response. Our hypothesis was that the promoter methylation of p11, a multifunctional protein involved in both depressive-like states and antidepressant treatment responses, is differently regulated in ECT responders vs. nonresponders and thus be a putative biomarker of ECT response. The chronic mild stress model of MDD was adapted with the aim to obtain rats that are resistant to conventional antidepressant drugs (citalopram). Subsequently, electroconvulsive stimulation (ECS) was used to select responders and nonresponders, and compare p11 expression and promoter methylation. In the rat experiments we found that the gene promoter methylation and expression of p11 significantly correlate with the antidepressant effect of ECS. Next, we investigated the predictive properties of p11 promoter methylation in two clinical cohorts of patients with pharmacoresistant MDD. In a proof-of-concept clinical trial in 11 patients with refractory MDD, higher p11 promoter methylation was found in responders to ECT. This finding was replicated in an independent sample of 65 patients with pharmacoresistant MDD. This translational study successfully validated the first biomarker reliably predicting the responsiveness to ECT. Prescreening of this biomarker could help to identify patients eligible for first-line ECT treatment and also help to develop novel antidepressant treatment procedures for depressed patients resistant to all currently approved antidepressant treatments.
PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations
Authors: di Blasio Laura , Puliafito Alberto , Gagliardi Paolo Armando , Comunanza Valentina , Somale Desiana , Chiaverina Giulia , Bussolino Federico , Primo Luca 
Published: January 2018

AbstractSomatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel–Trenaunay syndrome. Although VM are often limited to specific tissue areas and can be well treated, in extended or recurrent lesions novel therapeutic approaches are needed. We generated a mouse model of VM by local expression of PIK3CA-activating mutation in endothelial cells. PIK3CA-driven lesions are characterized by large areas of hemorrhage, hyperplastic vessels, infiltrates of inflammatory cells, and elevated endothelial cell density. Such vascular lesions are ameliorated by administration of dual PI3K/mTOR inhibitor, BEZ235, and mTOR inhibitor, Everolimus. Unexpectedly, the expression of PIK3CA-activating mutations in human endothelial cells results in both increased proliferation rates and senescence. Moreover, active forms of PIK3CA strongly promote the angiogenic sprouting. Treatment with PI3K/mTOR inhibitors restores normal endothelial cell proliferation rate and reduces the amount of senescent cells, whereas treatment with Akt inhibitor is less effective. Our findings reveal that PIK3CA mutations have a key role in the pathogenesis of VM and PIK3CA-driven experimental lesions can be effectively treated by PI3K/mTOR inhibitors.
Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity
Authors: Sheikhbahaei Shahriar , Turovsky Egor A. , Hosford Patrick S. , Hadjihambi Anna , Theparambil Shefeeq M. , Liu Beihui , Marina Nephtali , Teschemacher Anja G. , Kasparov Sergey , Smith Jeffrey C. , Gourine Alexander V. 
Published: January 2018

AbstractAstrocytes are implicated in modulation of neuronal excitability and synaptic function, but it remains unknown if these glial cells can directly control activities of motor circuits to influence complex behaviors in vivo. This study focused on the vital respiratory rhythm-generating circuits of the preBötzinger complex (preBötC) and determined how compromised function of local astrocytes affects breathing in conscious experimental animals (rats). Vesicular release mechanisms in astrocytes were disrupted by virally driven expression of either the dominant-negative SNARE protein or light chain of tetanus toxin. We show that blockade of vesicular release in preBötC astrocytes reduces the resting breathing rate and frequency of periodic sighs, decreases rhythm variability, impairs respiratory responses to hypoxia and hypercapnia, and dramatically reduces the exercise capacity. These findings indicate that astrocytes modulate the activity of CNS circuits generating the respiratory rhythm, critically contribute to adaptive respiratory responses in conditions of increased metabolic demand and determine the exercise capacity.
A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors
Authors: An Zhengwen , Sabalic Maja , Bloomquist Ryan F. , Fowler Teresa E. , Streelman Todd , Sharpe Paul T 
Published: January 2018

AbstractThe extent to which heterogeneity within mesenchymal stem cell (MSC) populations is related to function is not understood. Using the archetypal MSC in vitro surface marker, CD90/Thy1, here we show that 30% of the MSCs in the continuously growing mouse incisor express CD90/Thy1 and these cells give rise to 30% of the differentiated cell progeny during postnatal development. In adulthood, when growth rate homeostasis is established, the CD90/Thy1+ MSCs decrease dramatically in number. When adult incisors are cut, the growth rate increases to rapidly re-establish tooth length and homeostasis. This accelerated growth rate correlates with the re-appearance of CD90/Thy+ MSCs and re-establishment of their contribution to cell differentiation. A population of Celsr1+ quiescent cells becomes mitotic following clipping and replenishes the CD90/Thy1 population. A sub-population of MSCs thus exists in the mouse incisor, distinguished by expression of CD90/Thy1 that plays a specific role only during periods of increased growth rate.
Reemergence of high-Tc superconductivity in the (Li1-xFe
x
)OHFe1-ySe under high pressure
Authors: Sun J. P. , Shahi P. , Zhou H. X. , Huang Y. L. , Chen K. Y. , Wang B. S. , Ni S. L. , Li N. N. , Zhang K. , Yang W. G. , Uwatoko Y. , Xing G. , Sun J. , Singh D. J. , Jin K. , Zhou F. , Zhang G. M. , Dong X. L. , Zhao Z. X. , Cheng J.-G. 
Published: January 2018

AbstractIn order to elucidate pressure-induced second superconducting phase (SC-II) in A
x
Fe2−ySe2 (A = K, Rb, Cs, and Tl) having an intrinsic phase separation, we perform a detailed high-pressure magnetotransport study on the isoelectronic, phase-pure (Li1−xFe
x
)OHFe1−ySe single crystals. Here we show that its ambient-pressure superconducting phase (SC-I) with a critical temperature Tc ≈ 40 K is suppressed gradually to below 2 K and an SC-II phase emerges above Pc ≈ 5 GPa with Tc increasing progressively to above 50 K up to 12.5 GPa. Our high-precision resistivity data uncover a sharp transition of the normal state from Fermi liquid for SC-I to non-Fermi liquid for SC-II phase. In addition, the reemergence of high-Tc SC-II is found to accompany with a concurrent enhancement of electron carrier density. Without structural transition below 10 GPa, the observed SC-II with enhanced carrier density should be ascribed to an electronic origin presumably associated with pressure-induced Fermi surface reconstruction.
Experimental investigation of practical unforgeable quantum money
Authors: Bozzio Mathieu , Orieux Adeline , Trigo Vidarte Luis , Zaquine Isabelle , Kerenidis Iordanis , Diamanti Eleni 
Published: January 2018

AbstractWiesner’s unforgeable quantum money scheme is widely celebrated as the first quantum information application. Based on the no-cloning property of quantum mechanics, this scheme allows for the creation of credit cards used in authenticated transactions offering security guarantees impossible to achieve by classical means. However, despite its central role in quantum cryptography, its experimental implementation has remained elusive because of the lack of quantum memories and of practical verification techniques. Here, we experimentally implement a quantum money protocol relying on classical verification that rigorously satisfies the security condition for unforgeability. Our system exploits polarization encoding of weak coherent states of light and operates under conditions that ensure compatibility with state-of-the-art quantum memories. We derive working regimes for our system using a security analysis taking into account all practical imperfections. Our results constitute a major step towards a real-world realization of this milestone protocol.
Characterization of Nanodiamond-based anti-HIV drug Delivery to the Brain
Authors: Roy Upal , Drozd Vadym , Durygin Andriy , Rodriguez Jesse , Barber Paul , Atluri Venkata , Liu Xiaohua , Voss Thomas G. , Saxena Surendra , Nair Madhavan 
Published: January 2018

AbstractHuman Immunodeficiency Virus Type 1 (HIV-1) remains one of the leading causes of death worldwide. Present combination antiretroviral therapy has substantially improved HIV-1 related pathology. However, delivery of therapeutic agents to the HIV reservoir organ like Central nervous system (CNS) remains a major challenge primarily due to the ineffective transmigration of drugs through Blood Brain Barrier (BBB). The recent advent of nanomedicine-based drug delivery has stimulated the development of innovative systems for drug delivery. In this regard, particular focus has been given to nanodiamond due to its natural biocompatibility and non-toxic nature–making it a more efficient drug carrier than other carbon-based materials. Considering its potential and importance, we have characterized unmodified and surface-modified (-COOH and -NH2) nanodiamond for its capacity to load the anti-HIV-1 drug efavirenz and cytotoxicity,in vitro. Overall, our study has established that unmodified nanodiamond conjugated drug formulation has significantly higher drug loading capacity than surface-modified nanodiamond with minimum toxicity. Further, this nanodrug formulation was characterized by its drug dissolution profile, transmigration through the BBB, and its therapeutic efficacy. The present biological characterizations provide a foundation for further study ofin-vivopharmacokinetics and pharmacodynamics of nanodiamond-based anti-HIV drugs.
The compositional and nano-structural basis of fracture healing in healthy and osteoporotic bone
Authors: Mathavan Neashan , Turunen Mikael J. , Guizar-Sicairos Manuel , Bech Martin , Schaff Florian , Tägil Magnus , Isaksson Hanna 
Published: January 2018

AbstractOsteoporosis, a prevalent metabolic bone disorder, predisposes individuals to increased susceptibility to fractures. It is also, somewhat controversially, thought to delay or impair the regenerative response. Using high-resolution Fourier-transform infrared spectroscopy and small/wide-angle X-ray scattering we sought to answer the following questions: Does the molecular composition and the nano-structure in the newly regenerated bone differ between healthy and osteoporotic environments? And how do pharmacological treatments, such as bone morphogenetic protein 7 (BMP-7) alone or synergistically combined with zoledronate (ZA), alter callus composition and nano-structure in such environments? Cumulatively, on the basis of compositional and nano-structural characterizations of newly formed bone in an open-osteotomy rat model, the healing response in untreated healthy and ovariectomy-induced osteoporotic environments was fundamentally the same. However, the BMP-7 induced osteogenic response resulted in greater heterogeneity in the nano-structural crystal dimensions and this effect was more pronounced with osteoporosis. ZA mitigated the effects of the upregulated catabolism induced by both BMP-7 and an osteoporotic bone environment. The findings contribute to our understanding of how the repair processes in healthy and osteoporotic bone differ in both untreated and treated contexts and the data presented represents the most comprehensive study of fracture healing at the nanoscale undertaken to date.
Study of the soluble salts formation in a recently restored house of Pompeii by in-situ Raman spectroscopy
Authors: Prieto-Taboada Nagore , Fdez-Ortiz de Vallejuelo Silvia , Veneranda Marco , Marcaida Iker , Morillas Héctor , Maguregui Maite , Castro Kepa , De Carolis Ernesto , Osanna Massimo , Madariaga Juan Manuel 
Published: January 2018

AbstractThe walls and mural paintings of Pompeii exposed directly to the rainfalls are the most impacted in view of the observed decay. However, there are also wall paintings in protected rooms showing evidences of decaying. The aim of this research was to study the salts formed in such protected wall paintings only by non-invasive and in-situ Raman spectroscopy to understand their decaying processes. The perystile of the House of the Gilded Cupids (Regio VI, Insula 16), one of the most important houses of Pompeii was studied. Although an exhaustive restoration was carried out in 2004, a new conservation treatment was needed in 2013 and only two years later, extensive crystallizations of soluble salts were again threatening several of the restored surfaces, thus, the presence of an unsolved degradation pathway was deduced. Thank to the proposed methodology, it was pointed out that the key is the acidified rainfall impact in the non-protected backside of the walls containing the wall paintings. Thus, a new concept in the preservation of the houses of Pompeii is provided, in which the need of the protection of those walls from both sides is suggested to avoid the movement of water through the pores of the walls.