bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the IDH1 Mutation Status
Authors: Uckermann Ortrud , Juratli Tareq A. , Galli Roberta , Conde Marina , Wiedemuth Ralf , Krex Dietmar , Geiger Kathrin , Temme Achim , Schackert Gabriele , Koch Edmund , Steiner Gerald , Kirsch Matthias 
Published: December 2017

Abstract
Purpose: Somatic mutations in the human cytosolic isocitrate dehydrogenase 1 (IDH1) gene cause profound changes in cell metabolism and are a common feature of gliomas with unprecedented predictive and prognostic impact. Fourier-transform infrared (FT-IR) spectroscopy addresses the molecular composition of cells and tissue and was investigated to deduct the IDH1 mutation status.
Experimental Design: We tested the technique on human cell lines that were transduced with wild-type IDH1 or mutated IDH1 and on 34 human glioma samples. IR spectra were acquired at 256 positions from cell pellets or tissue cryosections. Moreover, IR spectra were obtained from fresh, unprocessed biopsies of 64 patients with glioma.
Results: IDH1 mutation was linked to changes in spectral bands assigned to molecular groups of lipids and proteins in cell lines and human glioma. The spectra of cryosections of brain tumor samples showed high interpatient variability, for example, bands related to calcifications at 1113 cm−1. However, supervised classification recognized relevant spectral regions at 1103, 1362, 1441, 1485, and 1553 cm−1 and assigned 88% of the tumor samples to the correct group. Similar spectral positions allowed the classification of spectra of fresh biopsies with an accuracy of 86%.
Conclusions: Here, we show that vibrational spectroscopy reveals the IDH1 genotype of glioma. Because it can provide information in seconds, an implementation into the intraoperative workflow might allow simple and rapid online diagnosis of the IDH1 genotype. The intraoperative confirmation of IDH1 mutation status might guide the decision to pursue definitive neurosurgical resection and guide future in situ therapies of infiltrative gliomas. Clin Cancer Res; 24(11); 2530–8. ©2017 AACR.
See related commentary by Hollon and Orringer, p. 2467
New reconstruction algorithm for digital breast tomosynthesis: better image quality for humans and computers
Authors: Rodriguez-Ruiz Alejandro , Teuwen Jonas , Vreemann Suzan , Bouwman Ramona W , van Engen Ruben E , Karssemeijer Nico , Mann Ritse M , Gubern-Merida Albert , Sechopoulos Ioannis 
Published: December 2017

Background The image quality of digital breast tomosynthesis (DBT) volumes depends greatly on the reconstruction algorithm. Purpose To compare two DBT reconstruction algorithms used by the Siemens Mammomat Inspiration system, filtered back projection (FBP), and FBP with iterative optimizations (EMPIRE), using qualitative analysis by human readers and detection performance of machine learning algorithms. Material and Methods Visual grading analysis was performed by four readers specialized in breast imaging who scored 100 cases reconstructed with both algorithms (70 lesions). Scoring (5-point scale: 1 = poor to 5 = excellent quality) was performed on presence of noise and artifacts, visualization of skin-line and Cooper’s ligaments, contrast, and image quality, and, when present, lesion visibility. In parallel, a three-dimensional deep-learning convolutional neural network (3D-CNN) was trained (n = 259 patients, 51 positives with BI-RADS 3, 4, or 5 calcifications) and tested (n = 46 patients, nine positives), separately with FBP and EMPIRE volumes, to discriminate between samples with and without calcifications. The partial area under the receiver operating characteristic curve (pAUC) of each 3D-CNN was used for comparison. Results EMPIRE reconstructions showed better contrast (3.23 vs. 3.10, P = 0.010), image quality (3.22 vs. 3.03, P < 0.001), visibility of calcifications (3.53 vs. 3.37, P = 0.053, significant for one reader), and fewer artifacts (3.26 vs. 2.97, P < 0.001). The 3D-CNN-EMPIRE had better performance than 3D-CNN-FBP (pAUC-EMPIRE = 0.880 vs. pAUC-FBP = 0.857; P < 0.001). Conclusion The new algorithm provides DBT volumes with better contrast and image quality, fewer artifacts, and improved visibility of calcifications for human observers, as well as improved detection performance with deep-learning algorithms.
Validation of the ICD-9 Diagnostic Code for Palliative Care in Patients Hospitalized With Heart Failure Within the Veterans Health Administration
Authors: Feder Shelli L. , Redeker Nancy S. , Jeon Sangchoon , Schulman-Green Dena , Womack Julie A. , Tate Janet P. , Bedimo Roger J. , Budoff Matthew J. , Butt Adeel A. , Crothers Kristina , Akgün Kathleen M. 
Published: December 2017

Background: Patients with heart failure (HF) are at increased risk of unmet palliative care needs. The International Classification of Diseases, Ninth Revision ( ICD-9) code, V66.7, can identify palliative care services. However, code validity for specialist palliative care in the Veterans Health Administration (VHA) has not been determined. Objective: To validate the ICD-9 code for specialist palliative care and determine common reasons for specialist palliative care consultation among VHA patients hospitalized with HF. Design: Electronic health record review of data from the Veterans Aging Cohort Study. Setting/Participants: The sample included 100 patients hospitalized with HF from 2003 to 2012. Measurements: Data from 50 patients with V66.7 were matched by age, race, site of care, hospital length of stay, intensive care unit admission, and fiscal year of study discharge to 50 patients with HF without V66.7 who had died within a year of hospitalization. We calculated positive and negative predictive values (PPV, NPV), sensitivity, and specificity. Results: All patients included in the sample were male, 66% black ethnicity, and mean age = 65 years (standard deviations [SD] ± 10.5 for cases; SD ± 9.8 for matches). Specialist palliative care was documented for 49 of 50 patients with V66.7 (PPV = 98%, 95% confidence interval [CI]: 88-99) and 9 of 50 patients without the code (NPV = 82%, 95% CI: 68-91). Sensitivity was 84% (95% CI: 72-92), and specificity was 98% (95% CI: 86-99). Establishing goals of care was the most frequent reason for palliative care consultation (43% of the sample). Conclusion: The ICD-9 code V66.7 identifies specialist palliative care for hospitalized patients with HF in the VHA. Replication of findings in other data sources and populations is needed.
Predictive Factors for Percutaneous Endoscopic Gastrostomy Tube Placement After Anterior Cervical Fusion
Authors: De la Garza-Ramos Rafael , Goodwin C. Rory , Abu-Bonsrah Nancy , Jain Amit , Passias Peter G. , Neuman Brian J. , Sciubba Daniel M. 
Published: December 2017

Study Design: Retrospective case-control study. Objectives: To identify incidence and risk factors for percutaneous endoscopic gastrostomy (PEG) tube placement after anterior cervical fusion (ACF). Methods: Adult patients undergoing elective ACF with/without corpectomy for spondylosis from 2002 to 2011 were identified using the Nationwide Inpatient Sample database. The primary outcome measure was PEG tube placement; secondary outcomes included in-hospital mortality, total hospital charges, and discharge disposition. Multiple regression analyses were conducted to identify independent predictors of PEG tube placement. Results: Of 164 097 patients, 217 (0.13%) required a PEG tube. Patients needing PEG tube placement were older (69 vs 52 years; P < .001) and more likely to be male (65% vs 46.6%; P < .001) when compared with control patients. After regression analysis, age over 65 year (odds ratio [OR] = 4.16; P < .001) was the strongest independent predictor for PEG tube placement; other associated factors included male gender (OR = 2.14; P < .001), congestive heart failure (OR = 4.11; P < .001), anemia (OR = 3.52; P < .001), alcohol abuse (OR = 2.80; P = .009), renal failure (OR = 2.25; P = .003), chronic lung disease (OR = 1.78; P < .001), corpectomy (OR = 2.16; P < .001), and fusion of ≥3 segments (OR = 1.74; P < .001). Mortality rate for patients requiring PEG tube placement was 5.1% versus 0.05% for controls ( P < .001); average hospital charges were $134 379 versus $39 519 ( P < .001), and nonroutine discharges were seen in 89.3% versus only 6.4% for controls ( P < .001). Conclusions: The incidence of PEG tube placement after ACF was 0.13% in this study. Identified risk factors included age >65, corpectomy, fusion of ≥3 segments, and various comorbidities. Additionally, there may be increased risk of in-hospital mortality, hospital charges, and nonroutine discharges among these patients.
Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air–lung study
Authors: Sack Coralynn , Vedal Sverre , Sheppard Lianne , Raghu Ganesh , Barr R. Graham , Podolanczuk Anna , Doney Brent , Hoffman Eric A. , Gassett Amanda , Hinckley-Stukovsky Karen , Williams Kayleen , Kawut Steve , Lederer David J. , Kaufman Joel D. 
Published: December 2017

We studied whether ambient air pollution is associated with interstitial lung abnormalities (ILAs) and high attenuation areas (HAAs), which are qualitative and quantitative measurements of subclinical interstitial lung disease (ILD) on computed tomography (CT).We performed analyses of community-based dwellers enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) study. We used cohort-specific spatio-temporal models to estimate ambient pollution (fine particulate matter (PM2.5), nitrogen oxides (NOx), nitrogen dioxide (NO2) and ozone (O3)) at each home. A total of 5495 participants underwent serial assessment of HAAs by cardiac CT; 2671 participants were assessed for ILAs using full lung CT at the 10-year follow-up. We used multivariable logistic regression and linear mixed models adjusted for age, sex, ethnicity, education, tobacco use, scanner technology and study site.The odds of ILAs increased 1.77-fold per 40 ppb increment in NOx(95% CI 1.06 to 2.95, p = 0.03). There was an overall trend towards an association between higher exposure to NOxand greater progression of HAAs (0.45% annual increase in HAAs per 40 ppb increment in NOx; 95% CI −0.02 to 0.92, p = 0.06). Associations of ambient fine particulate matter (PM2.5), NOxand NO2concentrations with progression of HAAs varied by race/ethnicity (p = 0.002, 0.007, 0.04, respectively, for interaction) and were strongest among non-Hispanic white people.We conclude that ambient air pollution exposures were associated with subclinical ILD.
Modelos para el diseño de experiencias transmedia en entornos educativos. Exploraciones en torno a The Walking Dead, La Odisea y Tom Sawyer
Authors: Montoya-Bermudez Diego-Fernando , Vásquez-Arias Mauricio 
Published: December 2017

Este texto presenta dos modelos para el diseño de experiencias transmediales aplicables desde el contexto de la comunicación a escenarios pedagógicos. Usando como método la investigación a través del diseño, se sistematizan dos prácticas de transmediación: una de carácter narrativo en contextos educativos formales, y la otra experiencial para entornos pedagógicos informales; ambos ejercicios con fines comunes: incentivar la lectura y la escritura en distintos públicos, y potenciar las prácticas transmedia como dinamizadores de procesos de alfabetización mediática, en una idea de poner los medios de comunicación del lado de la educación. Dichas propuestas permitieron evidenciar, tanto desde los sistemas intertextuales como desde los intermediales, las potencialidades de la transmedialidad como vector articulador de procesos de creación y experimentación. Finalmente, como aporte, el texto se centra en la elaboración de una propuesta metodológica para el diseño transmedia de experiencias mediante la cual se plantea la intermedialidad como una mirada más amplia hacia la transmediación.
Los eventos, herramienta clave en las estrategias de comunicación de marcas turísticas: de la linealidad a la transmedialidad
Authors: Martínez-Sala Alba-María , Campillo-Alhama Concepción 
Published: December 2017

La presente investigación aborda el reto que plantea la utilización de eventos en la creación y desarrollo de marcas turísticas. Desde el enfoque del protagonismo absoluto del individuo, se hace un recorrido conceptual de los eventos, de los eventos 2.0, de la narrativa transmedia y del transmedia branding para evaluar la explotación de su potencial comunicativo en la comunicación de marca. El objetivo principal se materializa en un análisis de la implementación de las premisas de la narrativa transmedia en la comunicación 2.0 de eventos. A partir de un muestreo intencional de trece destinos turísticos culturales españoles, Sitios Patrimonio Mundial, se analiza la difusión de eventos y la interacción generada en las redes sociales Facebook y Twitter mediante la metodología del case studies. Los resultados revelan una gestión incipiente de la comunicación transmedia de los eventos 2.0 en ambas redes sociales. Pese a ello, el análisis realizado y la bibliografía consultada corroboran el papel clave de los eventos en la creación de marcas país, territorio, turísticas, etc., y sustentan la principal aportación de esta investigación: la definición de las premisas de implementación de la narrativa transmedia en el ámbito de los eventos.
The WD+He star binaries as the progenitors of type Ia supernovae
Authors: Wang Bo , Liu Dongdong 
Published: December 2017

Abstract
Employing the MESA stellar evolution code, we computed He accretion onto carbon-oxygen white dwarfs (CO WDs).We found two possible outcomes for models in which the WD steadily grows in mass towards the Chandrasekhar limit. For relatively low He-accretion rates carbon ignition occurs in the center, leading to a type Ia supernova (SN Ia) explosion, whereas for relatively high accretion rates carbon is ignited off-center, probably leading to collapse. Thus the parameter space producing SNe Ia is reduced compared to what was assumed in earlier papers, in which the possibility of off-center ignition was ignored. We then applied these results in binary population synthesis modelling, finding a modest reduction in the expected birthrate of SNe Ia resulting from the WD+He star channel.
Effect of maternal age, height, BMI and ethnicity on birth weight: an Italian multicenter study
Authors: Spada Elena , Chiossi Giuseppe , Coscia Alessandra , Monari Francesca , Facchinetti Fabio 
Published: December 2017

Abstract

Aim:
To assess the effect of maternal age, height, early pregnancy body mass index (BMI) and ethnicity on birth weight.

Subjects and methods:
A cross-sectional study was conducted on more than 42,000 newborns. Ethnicity was defined by maternal country of birth or, when missing (<0.6% of records), by citizenship. The effect of maternal characteristics on birth weight was evaluated with general linear models.

Results:
Maternal height and BMI, although not age, significantly affected birth weight. Among Italian babies, 4.7% of newborns were classified as appropriate-for-gestational age (AGA) (birth weight between the 10th and the 90th centile) according to the country-specific Italian Neonatal Study (INeS) charts and were re-classified as either large-(LGA) (birth weight >90th centile) or small-(SGA) (birth weight <10th centile) for gestational age (GA) after adjustment for maternal characteristics. On the contrary, 1.6% of Italian newborns were classified as SGA or LGA according to the INeS charts and re-classified as AGA after adjustment. Maternal ethnicity had a significant impact on birth weight. Specifically, babies born to Senegalese mothers were the lightest, whilst babies born to Chinese mothers were the heaviest.

Conclusions:
Maternal height and early pregnancy BMI, should be considered in the evaluation of birth weight. The effect of ethnicity suggests the appropriateness of ethnic-specific charts. Further studies are necessary to determine if changes in birth weight classification, may translate into improved detection of subjects at risk of adverse outcomes.
Preparation and Physico-Chemical Stability of Dexamethasone Oral Suspension
Authors: Binson Guillaume , Venisse Nicolas , Bacle Astrid , Beuzit Karine , Dupuis Antoine 
Published: December 2017

AbstractBackgroundDexamethasone is commonly used to treat a wide variety of diseases including oncological disorders. The aim of this study was to propose a liquid formulation of dexamethasone. Therefore we have developed and assessed the stability of a 5 mg/mL dexamethasone oral suspension.MethodsA stability-indicating analytical method, using HPLC-UV, was developed and fully validated according to well-recognized international guidelines. The dexamethasone suspension was prepared using dexamethasone acetate powder and Ora-SweetResultsThe mean dexamethasone concentration of the compounded oral suspensions was equal to 5.07±0.17 mg/mL. No colour modifications, precipitate or suspending troubles was observed throughout the storage period and the pH of the oral suspensions was decreased slightly, from 4.41±0.01 to 4.20±0.02. According to the dexamethasone content determined by HPLC-UV, whatever storage condition was used, no significant degradation of dexamethasone occurred over the 60 days of the study period.ConclusionDexamethasone oral suspension prepared according to our conditions is stable over 60 days under regular storage temperatures (at 4±2 °C or at 21±3 °C).
Reexamination of the crystal structure of semseyite, Pb9Sb8S21
Authors: Matsushita Yoshitaka 
Published: December 2017

Abstract
The crystal structure of semseyite, Pb9Sb8S21 was successfully refined using a single-crystal specimen from Wolfsberg, Harz, Germany, having chemical composition (EPMA) Pb9.01(1)Sb8.00(3)S21.05(5). The structure belongs to the monoclinic C2/c space group (a=13.6267(10) Å, b=11.9742(9) Å, c=24.5891(18) Å, β=105.997(3)°, V=3856.8(5) Å3, Z=4, Dc
=6.048 g/cm3). Crystal structure refinement with all atoms refined anisotropically converged to R
1=4.64% (I>2σ(I)). The crystal structure is built of two subunits (A and B) showing TlSbS2-like topology. Each of them stacks parallel to (001), and c/2 in thickness. Two cation sites (Pb1 and Sb5) located at central part of the subunit, show mixed occupancy behavior as 95% Pb and 5% Sb at the Pb5 site, and 95% Sb and 5% Pb at the Sb1 site, respectively. Each of subunits are related by unit cell-level twinning mechanism “tropochemical cell twinning” with the TlSbS2-like subunits alternatively parallel to (1 1 −4) and (−1 1 4) planes.
Dynamic Fracture Characterization of Cantilever Structure Specimens with V-Notch Tips
Authors: Yue Zhongwen , Zhang Wang , Song Yao , Hu Qingwen , Xie Luzhou 
Published: December 2017

Abstract
The dynamic fracture behavior of polymethyl methacrylate (PMMA) cantilever structure specimens with different notch angles under low-speed impact is studied using the digital array high-speed imaging system. First, dynamic caustic patterns at the notch tip and the propagating crack tip, respectively, are recorded. Then, the evolution of the stress intensity factor (SIF) and the crack propagation velocity are calculated, which are illustrated in detail based on the stress wave. Finally, the effect of notch angle on fracture behavior is analyzed, and the microscopic characterizations of the fracture surface are described. The results play an important role in evaluating the dynamic fracture properties of cantilever structures.
Genomic Prediction and Association Mapping of Curd-Related Traits in Gene Bank Accessions of Cauliflower
Authors: Thorwarth Patrick , Yousef Eltohamy A A , Schmid Karl J 
Published: December 2017

AbstractGenetic resources are an important source of genetic variation for plant breeding. Genome-wide association studies (GWAS) and genomic prediction greatly facilitate the analysis and utilization of useful genetic diversity for improving complex phenotypic traits in crop plants. We explored the potential of GWAS and genomic prediction for improving curd-related traits in cauliflower (Brassica oleracea var. botrytis) by combining 174 randomly selected cauliflower gene bank accessions from two different gene banks. The collection was genotyped with genotyping-by-sequencing (GBS) and phenotyped for six curd-related traits at two locations and three growing seasons. A GWAS analysis based on 120,693 single-nucleotide polymorphisms identified a total of 24 significant associations for curd-related traits. The potential for genomic prediction was assessed with a genomic best linear unbiased prediction model and BayesB. Prediction abilities ranged from 0.10 to 0.66 for different traits and did not differ between prediction methods. Imputation of missing genotypes only slightly improved prediction ability. Our results demonstrate that GWAS and genomic prediction in combination with GBS and phenotyping of highly heritable traits can be used to identify useful quantitative trait loci and genotypes among genetically diverse gene bank material for subsequent utilization as genetic resources in cauliflower breeding.
Produtividade de massa seca e atributos físico-químicos da forrageira capim mombaça (Panicum maximum) submetido a diferentes lâminas de irrigação e doses de nitrogênio
Authors: Cardoso Jean Claudio Queiroz , Tomaz Rafael Simões , Lima Ronaldo Cintra 
Published: December 2017

O capim Mombaça surge como boa alternativa para produtores em sistemas intensivos de produção em que se faz o uso da irrigação e adubação. O correto manejo de recursos hídricos via irrigação e o fornecimento de nutrientes como N, P, K é imprescindível para o bom desenvolvimento dessas espécies. O objetivo do trabalho foi verificar a influência de diferentes lâminas de irrigação e doses de nitrogênio sobre a produtividade de massa seca de forragem e atributos químicos do capim Mombaça. O experimento foi conduzido na FCAT-UNESP-Dracena. O delineamento utilizado foi DIC em esquema de parcelas subdivididas com 4 repetições, sendo tratamento principal 5 lâminas de irrigação, para repor o déficit hídrico, a partir da ETo, sendo elas: 130%; 100%; 70%; 30% e 0% (Kc=1,0). O tratamento secundário foi composto por 4 doses de nitrogênio (N): 0 (zero); 50; 100 e 150 Kg ha-1. Foram avaliados os macronutrientes foliares: nitrogênio (NF), fósforo (PF), potássio (KF) pela técnica da diagnose foliar; e a massa seca da forrageira. Foi realizada análise de variância e teste de Skott-knott (p<0,05) para comparação de médias. Foi detectada influência das doses de nitrogênio sobre a característica altura de plantas nos respectivos períodos analisados. Os teores foliares de N, P, K também foram beneficiados. O uso de maiores lâminas de irrigação e doses de nitrogênio proporcionou aumento na produção de massa seca de forragem. PALAVRAS-CHAVE: Manejo de irrigação, capim-mombaça, nutrientes foliares.
Analysis the economic growth factors of strategic zone in Aceh Province, Indonesia
Authors: Abd. Jamal, Muhammad Nasir Rahmattullah*, Mohd. Nur Syechalad, 
Published: December 2017

The purpose of this study was to analyse the economic growth factors strategic zone in Aceh Province, Indonesia of 2010-2016. The data used was data panel consisting of six zones namely the central, north, east, southeastern, south and west. The independent variables was development gaps, government budget, electrical energy, information technology, labor from magister/doctor. Dependent variable was economic growth. The method used was panel data regression. The result show that a model of fixed effect good enough explain economic growth. Factors that Influential very significant was information technology and electrical energy