bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Dual Function of the Polybasic Juxtamembrane Region of Syntaxin 1A in Clamping Spontaneous Release and Stimulating Ca2+-Triggered Release in Neuroendocrine Cells
Authors: Singer-Lahat Dafna , Barak-Broner Noa , Sheinin Anton , Greitzer-Antes Dafna , Michaelevski Izhak , Lotan Ilana 
Published: November 2017

The exact function of the polybasic juxtamembrane region (5RK) of the plasma membrane neuronal SNARE, syntaxin 1A (Syx), in vesicle exocytosis, although widely studied, is currently not clear. Here, we addressed the role of 5RK in Ca2+-triggered release, using our Syx-based intramolecular fluorescence resonance energy transfer (FRET) probe, which previously allowed us to resolve a depolarization-induced Ca2+-dependent close-to-open transition (CDO) of Syx that occurs concomitant with evoked release, both in PC12 cells and hippocampal neurons and was abolished upon charge neutralization of 5RK. First, using dynamic FRET analysis in PC12 cells, we show that CDO occurs following assembly of SNARE complexes that include the vesicular SNARE, synaptobrevin 2, and that the participation of 5RK in CDO goes beyond its participation in the final zippering of the complex, because mutations of residues adjacent to 5RK, believed to be crucial for final zippering, do not abolish this transition. In addition, we show that CDO is contingent on membrane phosphatidylinositol 4,5-bisphosphate (PIP2), which is fundamental for maintaining regulated exocytosis, as depletion of membranal PIP2 abolishes CDO. Prompted by these results, which underscore a potentially significant role of 5RK in exocytosis, we next amperometrically analyzed catecholamine release from PC12 cells, revealing that charge neutralization of 5RK promotes spontaneous and inhibits Ca2+-triggered release events. Namely, 5RK acts as a fusion clamp, making release dependent on stimulation by Ca2+.SIGNIFICANCE STATEMENTSyntaxin 1A (Syx) is a central protein component of the SNARE complex, which underlies neurotransmitter release. Although widely studied in relation to its participation in SNARE complex formation and its interaction with phosphoinositides, the function of Syx's polybasic juxtamembrane region (5RK) remains unclear. Previously, we showed that a conformational transition of Syx, related to calcium-triggered release, reported by a Syx-based FRET probe, is abolished upon charge neutralization of 5RK (5RK/A). Here we show that this conformational transition is dependent on phosphatidylinositol 4,5-bisphosphate (PIP2) and is related to SNARE complex formation. Subsequently, we show that the 5RK/A mutation enhances spontaneous release and inhibits calcium-triggered release in neuroendocrine cells, indicating a previously unrecognized role of 5RK in neurotransmitter release.
Религиозно­-церковная политика советского режима в отношении Польской автокефальной православной церкви на Волыни в 1939–1941 гг.
Authors: Гордиенко Вячеслав , Гордиенко Галина 
Published: November 2017

В статье раскрывается содержание советской религиозно­‑церковной политики в первый период Второй мировой войны на оккупированных польских землях. Показаны условия жизнедеятельности части Польской автокефальной православной церкви (ПАПЦ), которая оказалась на советской территории. Акцентировано внимание на противоречиях в отношениях советского атеистического режима к православным в Западной Украине и Белоруссии. Изложены факты, которые опровергают концепцию «либерализации» религиозной политики советского партийно­‑государственного руководства в 1939–1941 гг. Анализируется активность Московского патриархата, направленную на переподчинение православных приходов ПАПЦ в Западной Украине и Белоруссии под юрисдикцию РПЦ. В статье доказывается, что инициатором деятельности Московского патриархата по ликвидации автокефалии Польской православной церкви на оккупированных землях были советские спецслужбы. Показано, что мероприятия по переподчинению православных приходов бывшей Польской православной церкви Московскому патриархату осуществлялись под контролем и опекою органов НКВД. Обосновывается вывод о том, что наличие в Западной Украине и Белоруссии полноценной, функциональной, численной и автокефальной православной конфессии вынудило советский режим к взаимодействию с Московским патриархатом. Доказывается, что вновьприобретенный опыт был потом использован партийно­‑государственным руководством СССР в Прибалтике и в годы немецко­‑советской войны.
The Impact of Prenatal Yoga on Exercise Attitudes and Behavior: Teachable moments from a Randomized Controlled Trial
Authors: Babbar Shilpa , Porter Blake W. , Williams Karen B. 
Published: November 2017

Abstract
Objective: Pregnancy serves as an opportune time for “teachable moments” to elicit positive behavior change. We evaluated change in exercise perception, behavior and gestational weight gain in participants engaged in a one-hour educational experience.
Methods: Women between 28 0/7 to 36 6/7 weeks with no prior yoga experience carrying a non-anomalous singleton fetus participated in a randomized controlled trial on prenatal yoga. The yoga group engaged in a one-hour yoga class; the attention control educational group, in a one-hour presentation on exercise, nutrition and obesity in pregnancy. Maternal perception of yoga, exercise effects and current health status was conducted before and after the intervention. Gestational weight gain (GWG) and body mass index (BMI) were assessed. A postpartum survey was performed to determine self-reported behavioral changes during and after pregnancy.
Results: Over 6 months, 52 women were randomized and 46 (88%) completed the study. Women reported a more positive attitude towards exercise and yoga after the yoga intervention. Total GWG was similar (yoga 32.9 versus education 32.8 pounds, p = 0.98). Stratified by pre-pregnancy BMI, 13% gained within and 61% gained above the Institute of Medicine guidelines in each group. Of 29 inactive women prior to the intervention, 60% of the yoga group and 75% of the education group began prenatal exercises after the intervention and 50% of each group continued to exercise after delivery. There were no significant differences between groups.
Conclusion: A one-time, one-hour intervention teaching a new exercise or educating women during pregnancy can positively impact pregnancy behaviors and perception with the potential to improve maternal and neonatal outcomes.
Clinical Trial Registration: Clinicaltrials.gov, www.clinicaltrials.gov, NCT02063711.
Yoga practice is associated with superior motor imagery performance
Authors: Hartnoll Susannah H , Punt T David 
Published: November 2017

Abstract
Yoga is an activity that aims to integrate physical, mental and spiritual elements and is an increasingly popular approach to enhancing physical fitness. The integration of imagery within yoga practice is considered an important component and may be critical in contributing to the benefits of yoga that have been reported. In this study, we tested whether individuals who practice yoga demonstrate superior performance on an objective measure of implicit motor imagery. Thirty-six participants (18 yoga, 18 non-yoga) matched for age, sex and handedness, undertook the hand laterality recognition task; an objective measure of implicit motor imagery performance. Accuracy and response times were gathered and analysed to determine any group differences as well as any differences relating to the typical hallmarks of imagery (i.e. dominance and awkwardness effects) on the task. Response Times (RTs) in the yoga group were significantly faster than controls (p &lt; 0.05) and there was also a trend towards greater accuracy for the Yoga group (p = 0.073). Dominance effects (faster responses to images corresponding with the dominant limb) and Awkwardness effects (faster responses to images corresponding with natural compared with awkward postures) were evident across groups, supporting the participants' use of motor imagery in undertaking the task. Additionally, a Group × Awkwardness interaction (p &lt; 0.05) revealed that the enhanced imagery performance for the yoga group was most pronounced for awkward postures. This is the first study to show that yoga practice is associated with superior motor imagery performance; an association that may be important in explaining the established rehabilitative value of yoga for chronic pain.
Guidelines for teaching yoga to women with breast cancer-related lymphoedema: an evidence-based approach
Authors: Loudon Annette , Barnett Tony , Williams Andrew D. , Visentin Denis , Immink Maarten A. , Piller Neil 
Published: November 2017

Abstract
Breast cancer-related lymphoedema (BCRL) is a chronic condition that requires lifelong management to prevent the condition worsening and to reduce the threat of infection. Women are affected in all domains of their life. As a holistic practice, yoga may be of benefit by reducing both the physical and psychosocial effects of lymphoedema. Women with BCRL are attending yoga classes in increasing numbers, so it is essential that yoga be based on principles that ensure lymphoedema is controlled and not exacerbated. Two Randomised Controlled Trials with a yoga intervention have had positive results after an 8-week intervention (n=28) and 6-months after a 4-week intervention (n=18). The first study had several significant results and women reported increased biopsychosocial improvements. Both studies showed trends to improved lymphoedema status. The yoga interventions compromised breathing, physical postures, meditation and relaxation practices based on Satyananda Yoga®, with modifications to promote lymphatic drainage and following principles of best current care for those with BCRL. Individual needs were considered. The yoga protocol that was used in the 8-week trial is presented. Our aim is to provide principles for yoga teachers/therapists working with this clientele that can be adapted to other yoga styles. Further, these principles may provide a basis for the development of yoga programs for people with secondary lymphoedema in other areas of their body as the population requiring cancer treatment continues to increase. Whilst the style of yoga presented here has had positive outcomes, further application and research is needed to fully demonstrate its effectiveness.
A REVIEW STUDY OF ZINC OXIDE NANOPARTICLES SYNTHESIS FROM PLANT EXTRACTS
Authors: Lakshmi Sagili Jhansi , Bai R S Roopa , H Sharanagouda , Nidoni Uday kumar 
Published: November 2017

The development of nanotechnology is making the interest of researchers towards the synthesis of nanoparticles for the bioapplication. Metal oxides such as ZnO have received increasing attention as antibacterial materials in recent years because of their stability under harsh processing conditions, and also because they are generally regarded as safe materials for human beings and animals. Zinc activates 300 enzymes, and it plays a role in many other phenomena like growth, membrane stability, bone mineralization, tissue growth, and repair, wound healing and cell signalling.
Many studies have shown that ZnO nanoparticles have enhanced antibacterial activity. Use of plant and plant materials for the synthesis of Zinc nanoparticles is relatively new and exciting research field. Various plants were used for the synthesis of nanoparticles using a green synthesis method.
Nanoparticles were synthesized from all the parts of the plant separately like stem, flower, leaf, latex, root, peel, stem bark and fruits. The prepared nanoparticles of Zinc oxide were characterized by using XRD, FTIR, UV-VIS Spectroscopy, EDAX, Particle size analyzer, TGA, and SEM.
The objective of this review was to report on the synthesis of Zinc oxide nanoparticles by using different plant extracts and their significance in different fields.
Call for Submissions: Special Issue, Cultural and Pedagogical Inquiry (CPI)
Authors: DePass Cecille 
Published: November 2017

The Politics of Contemporary Education with Guest Editor: Paul A. Crutcher (University of Arkansas - Little Rock)Through scholarly and creative work, this proposed CPI Special Issue explores central aspects and impacts of the contentious politics of contemporary education. Potential contributors to this Special Issue should submit a proposal to Dr. Paul A. Crutcher (pacrutcher@ualr.edu) by December 15, 2017. Proposals should be single Word or PDF files that include: (a) a title of up to 150 characters, (b) an abstract of up to 150 words, and (c) a description of the proposed paper or creative work of up to 500 words.
NEOLIBERALIZAM I OBRAZOVANJE U KONTEKSTU GLOBALNE OBRAZOVNE POLITIKE
Authors: Kanić Sanela , Kovač Vesna 
Published: November 2017

Pojam globalne obrazovne politike javio se u posljednjih nekoliko desetljeća, a riječ je o fenomenu koji obuhvaća obilježja obrazovnih reformi prisutnih na globalnoj razini do kojih je došlo uslijed globalizacijskih mehanizama, odnosno opisuje ih, definira i nastoji ustanoviti tko stoji iza njihove diseminacije. Uslijed globalizacije, došlo je i do tvorbe transnacionalnog obrazovnog prostora gdje su se, uz vlade, pojavili i novi akteri, čiji su utjecaji na obrazovne politike postajali sve snažniji. Najistaknutijima se smatraju međunarodne organizacije koje različitim mehanizmima utječu na vlade mnogih zemalja, prilikom čega imaju mogućnost promicanja vlastitih agenda koje karakterizira jedna zajednička točka – neoliberalna doktrina. Pojava neoliberalizma uslijed svjetske ekonomske stagnacije sedamdesetih godina prošlog stoljeća rezultirala je prisutnošću tržišnih rješenja s naglaskom na učinkovitost, konkurenciju i slobodu izbora, što se, zahvaljujući globalizaciji, trajno ukorijenilo u obrazovne sustave gotovo svih zemalja. Pojave poput decentralizacije, privatizacije, novog javnog menadžmenta i novog profesionalizma postale su temelj za formiranje novih globalnih obrazovnih trendova, a uključenost privatnog sektora i redefinirana uloga vlade u pružanju i financiranju obrazovnih usluga smatra se svojevrsnim imperativom kada je riječ o neoliberalnim utjecajima na obrazovanje. Naposljetku, došlo je do prisutnosti javno-privatnih partnerstva, čija pojavnost uprizoruje prodor privatizacije i tržišnih mehanizama u obrazovanje.
The Impact of World Food Price Fluctuation towards Indonesian Macroeconomics
Authors: Ilmia Jami - , Wilantari Regina Niken , Luthfi Agus - 
Published: November 2017

<p class="Normal1"><span class="normalchar"><em>Stability of price is a crucial factor for export and import activities, especially food commodities.</em></span><span class="apple-converted-space"><span> </span></span><span class="normalchar"><em>Indonesia with the characteristics of a small open economy are vulnerable to external price shock as the implication of economic globalization.</em></span><span class="apple-converted-space"><span> </span></span><span class="normalchar"><em>Understanding the food price shock useful for designing risk mitigation to minimize the effects of shocks to macroeconomic variables.</em></span><span class="apple-converted-space"><span> </span></span><span class="normalchar"><em>The purpose of this research is to analyze the impact of macroeconomics from </em></span><span class="normalchar"><em><span lang="EN-US">V</span>ector </em></span><span class="normalchar"><em><span lang="EN-US">A</span>uto</em></span><span class="normalchar"><em><span lang="EN-US">-R</span>egression (VAR) methods.</em></span><span class="apple-converted-space"><span> </span></span><span class="normalchar"><em>The sensitivity of impulse response estimation and variance decomposition which outlines how large and how the effect of the food price shock.</em></span><span class="apple-converted-space"><span> </span></span><span class="normalchar"><em>Impulse response analysis shows shocks on global food price got the response by fastest and the most powerful by inflation.</em></span><span class="apple-converted-space"><span> </span></span><span class="normalchar"><em>While the description of variance decomposition, variation described by economic growth.</em></span><span class="apple-converted-space"><span> </span></span><span class="normalchar"><em>The results show that the global food price affects economic growth that is transmitted through inflation.</em></span></p>
The Epidemiology of Adult Distal Femoral Shaft Fractures in a Central London Major Trauma Centre Over Five Years
Authors: Khan Akib Majed , Tang Quen Oat , Spicer Dominic 
Published: November 2017

Background:Distal femoral fractures account for 3-6% of adult femoral fractures and 0.4% of all fractures and are associated with significant morbidity and mortality rates. As countries develop inter-hospital trauma networks and adapt healthcare policy for an aging population there is growing importance for research within this field.Methods:Hospital coding and registry records at the central London Major Trauma Center identified 219 patients with distal femoral shaft fractures that occurred between December 2010 and January 2016. CT-Scans were reviewed resulting in exclusion of 73 inappropriately coded, 10 pediatric and 12 periprosthetic cases. Demographics, mechanism of injury, AO/OTA fracture classification and management were analyzed for the remaining 124 patients with 125 fractures. Mann Whitney U and Chi Squared tests were used during analyses.Results:The cases show bimodal distribution with younger patients being male (median age 65.6) compared to female (median age 71). Injury caused through high-energy mechanisms were more common in men (70.5%) whilst women sustained injuries mainly from low-energy mechanisms (82.7%) (p<0.0001). Majority of fractures were 33-A (52.0%) followed by 33-B (30.4%) and 33-C (17.6%). Ninety-two (73.6%) underwent operative management. The most common operation was locking plates (64.1%) followed by intramedullary nailing (19.6%).Interpretation:The epidemiology of a rare fracture pattern with variable degrees of complexity is described. A significant correlation between biological sex and mechanism of injury was identified. The fixation technique favored was multidirectional locking plates. Technical requirements for fixation and low prevalence of 33-C fractures warrant consideration of locating treatment at centers with high caseloads and experience.
PHYCHEMISTRY, PHYTOCHEMICAL, PHARMACOLOGICAL AND MOLECULAR STUDY OF ZINGIBER OFFICINALE ROSCOE: A REVIEW
Authors: Ashraf Kamran , Sultan Sadia , Shah Sayed Adnan Ali 
Published: November 2017

The rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, is one of the most widely used spice and condiment. It is also an integral part of many traditional medicines and has been extensively used in Chinese, Ayurvedic, Tibb-Unani, Srilankan, Arabic, and African traditional medicines, since antiquity, for many unrelated human ailments including common colds, fever, sore throats, vomiting, motion sickness, gastrointestinal complications, indigestion, constipation, gastritis, epigastric discomfort, gastric ulcerations, indigestion, nausea vomiting etc. and scientific studies have validated the ethnomedicinal uses. The chemistry, phytochemical, pharmacological and molecular studies of Z. officinale is reviewed. This review was compiled to provide consolidated information covering different aspects of the plant, to provide a basis on which to plan future studies and to promote sustainable use of Z. officinale.
DEVELOPMENT OF NEW PYRAZOLE HYBRIDS AS ANTITUBERCULAR AGENTS: SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDY
Authors: Shaikh Sameer I. , Zaheer Zahid , Mokale Santosh N. , Lokwani Deepak K. 
Published: November 2017

Objective: synthesis of new 1, 3-diphenyl pyrazole derivatives 9(a-f) and 10(a-f) using molecular hybridization approach for antitubercular and cytotoxic studies.Methods: The structures of synthesized compounds were confirmed by 1H-NMR, 13C-NMR and mass spectra’s. The antitubercular activity of compounds and standard drugs were assessed against Mycobacterium tuberculosis using microplate Alamar Blue assay (MABA). The cytotoxic activities were performed by Sulforhodamine B (SRB) assay. The molecular docking and in silico ADME prediction were studied by using Schrodinger.Results: The results reveals that the compounds 9c, 9d, 10c and 10d exhibited substantial antitubercular potential with MIC < 20 μM. The cytotoxic studies revealed that the active compounds (9d, 10a, and 10d) are non-toxic to HeLa cancer cell lines with selectivity index >10. The molecular docking study was performed to study the binding orientation and affinity of synthesized compounds for InhA enzyme.Conclusion: The study explored that the 1, 3-diphenyl pyrazole hybrids coupled with well known antitubercular drugs could be a potential lead for antitubercular agents. In-silico molecular docking study helps to identify their corresponding intermolecular ligand-protein interactions with target enzyme. Also ADME prediction studies revealed that the compounds were in acceptable range to have pharmacokinetic parameters.
Factors associated with long-term vertical skeletal changes induced by facemask therapy in patients with Class III malocclusion
Authors: Kwak Hee-Jong , Park Hae-Jin , Kim Yoon-Ji , Lee Dong-Yul 
Published: November 2017

ABSTRACT

Objectives:
This study investigated the long-term vertical skeletal changes induced by facemask therapy in patients with Class III malocclusion and different vertical skeletal patterns.

Materials and Methods:
A total of 54 patients (20 boys and 34 girls; mean age, 7.7 ± 2.0 years) with Class III malocclusion who were successfully treated with facemask therapy were included in this study. Vertical skeletal changes (overbite depth indicator, angle between the Sella-Nasion (SN) plane and Gonion-Gnathion (GoGn) line, angle between the Frankfort horizontal (FH) plane and mandibular plane, gonial angle, and angle between the SN plane and palatal plane) were measured on lateral cephalograms from before treatment (T0) to after facemask therapy (T1) and from T0 to after retention (T2). Multivariate linear regression analysis was used to study the associations of the patients' skeletal patterns with the short-term (T0–T1) and long-term (T0–T2) vertical skeletal changes as a result of facemask therapy.

Results:
The mean treatment period of facemask therapy (T0–T1) was 1.4 ± 0.6 years, and the mean retention period (T1–T2) was 6.9 ± 2.6 years. Age at T0 was significantly correlated with vertical skeletal changes from T0 to T1. Differences in the treatment results between sexes were not significant. The angle between point A-point B line and mandibular plane to mandibular plane angle at T0 and the angle between the FH plane and mandibular plane at T0 were significant predictors for short-term and long-term changes. Changes in the Sella-Nasion-point A from T0 to T1 and from T1 to T2 significantly affected vertical changes in the short term and long term, respectively.

Conclusions:
Vertical skeletal changes as a result of facemask therapy are significantly associated with severity of the skeletal Class III malocclusion and mandibular plane angulation before treatment and the amount of forward maxillary growth during the treatment and retention periods.
Basal Cell Carcinoma with Adnexal Differentiation, a Rare Entity and Challenging Histopathology Presentation. Case Report
Authors: Paniagua Gonzalez Lizy M , Shimizu Ikue 
Published: November 2017

We report an 88 year-old male with a history of multiple non-melanoma skin cancers who presented for Mohs micrographic surgery with a biopsy proven infiltrative and nodular basal cell carcinoma located on the right posterior ear. During Mohs surgery, frozen sections revealed a typical nodular BCC on stage 1. However, on stage 2, frozen section showed nodular aggregates of regular cuboidal cells with pale cytoplasm with areas mimicking multi-nucleated giant cells. Deeper permanent sections were consistent with BCC with adnexal differentiation. This histopathological presentation of basal cell carcinoma is uncommon and we sought to report the clinical and pathological features of this case.