bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory Effect of Non-Coding RNAs on Programmed Cell Death in Melanoma: Novel Therapeutic Crosstalk for Targeted Therapy
Authors: Fazlollahpour-naghibi Andarz , Taha Seyed Reza , Shariatzadeh Mahdieh , Daneshdoust Danyal , Bagheri Kimia , Farkhondeh Tahereh , Samini Mohammad , Pourhanifeh Mohammad Hossein , Samarghandian Saeed 
Published: February 2025

Abstract:
Cutaneous melanoma, one of the most fatal and aggressive types of skin cancer, is a malignant tumor created from pigment-producing cells called melanocytes. The mor-bidity and incidence rate of melanoma are increasing around the world. Considering all developments in diagnostic and therapeutic approaches, early diagnosis and more effective targeted therapies are still urgent for melanoma. Non-coding RNAs (ncRNAs), including microRNAs and long non-coding RNAs, are key role players in fundamental cellular pro-cesses and have various biological properties. It has been demonstrated that the dysregula-tion of these biomarkers contributes to melanoma pathogenesis. Furthermore, programmed cell death (PCD), as an important cellular event, has been shown to play a role in the initi-ation and progression of cutaneous melanoma. Recent investigations have reported that the interplay between ncRNAs and PCD can be considered a novel choice for targeted therapy in melanoma. Thus, this review discusses PCD-related ncRNAs in melanoma, focusing on underlying pathways.
Evaluating the influence of St. John’s Wort on Naproxen Pharmacokinetics and Pharmacodynamics: A Drug Interaction Assessment
Authors: Halumane Keerthana S. , Kadiri Sunil Kumar 
Published: February 2025

Introduction:
Rheumatoid arthritis (RA) is a chronic autoimmune disease which leads to pain and disability that may trigger anxiety and sleep disturbances. Naproxen and St.John’s Wort concomitant administration in RA and anxiety raises the question of safety due to a potential drug interaction.

Materials and Methods:
Albino Wistar rats were treated with naproxen and St. John’s Wort for 30 days. The study involved the evaluation of safety of naproxen when combined with St. John’s Wort by estimation of biochemical markers such as SGOT, SGPT, TG’s, Creatinine, BUN, the extent of gastromucosal damage and estimation of AUC, t1/2 and Clearance using blood serum analysis with HPLC after 30 days of treatment. Histopatho-logical studies were also conducted to determine the tissue architecture.

Results:
Elevated levels of hepatic markers SGOT, SGPT, TG, and gastro-mucosal dam-age with enhanced ulcer index were found in naproxen-St. John’s Wort treated rats as compared to only naproxen treated rats. HPLC analysis displayed increased AUC and t1/2 of naproxen with decreased clearance in naproxen-St. John’s Wort treated rats. Histo-pathological findings revealed tissue rupture and mucosal damage supporting the naproxen toxicity.

Conclusion:
Consulting a healthcare professional before combining St. John's Wort with naproxen is essential to assess potential risks, manage drug interactions, and ensure safety. Personalized advice helps optimize treatment outcomes for both rheumatoid arthritis and mental health.

other:
Keywords: Naproxen, St. John’s Wort, biochemical, gastromucosal, drug interactions, NSAID, rheumatoid arthritis.
Life’s Essential 8, Cardiovascular Health, and Chronic Kidney Disease Progression among Hispanic/Latino Adults, the HCHS/SOL Study
Authors: Chakrabarti Amit , Drexler Yelena , Swift Samuel , Lash James P. , Kaplan Robert C. , Perreira Krista M , Mendoza Jair Munoz , Daviglus Martha , Pirzada Amber , Sotres-Alvarez Daniela , Johns Tanya , Elfassy Tali 
Published: February 2025

Background:
The primary cause of death in chronic kidney disease (CKD) is cardiovascular disease. Life’s Essential 8 (LE8) is an established measure of cardiovascular health. Our objective was to examine the relationship between cardiovascular health (LE8 score) and CKD progression among Hispanic/Latino adults, an understudied but growing population.

Methods:
The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a longitudinal cohort of Hispanic/Latino adults aged 18-74 years from four cities in the United States, examined at visit 1 (V1, 2008-2011) and visit 2 (V2, 2014-2017). At V1, participants underwent a comprehensive assessment of health behaviors (diet, physical activity, nicotine exposure, sleep health) and clinical measurements (body mass index, blood lipids, blood glucose, blood pressure) used to estimate an LE8 score (range: 0 to 100). We included 1,284 participants with CKD at V1, defined as estimated GFR (eGFR) <60 ml/min/1.73 m2 and/or urine albumin-to-creatinine ratio (ACR) ≥30 mg/g. Change in eGFR and log(ACR) were defined as the difference in each measure between V1 and V2. To estimate the association between LE8 score with change in eGFR and log(ACR), we used linear regression models adjusted for follow-up time and demographic, socio-economic, and clinical factors. All analyses accounted for HCHS/SOL complex survey design.

Results:
Among 1284 Hispanic/Latino participants with CKD at V1, mean age was 48.6 years (Standard Error: 0.8), 57.2% were women, and mean LE8 score was 61.1 (Standard Error: 0.7). Over an average of six years of follow-up, eGFR declined by 5.8 ml/min/1.73 m2 and log(ACR) declined by 0.60. From multivariable adjusted models, for each 10-unit higher LE8 score, eGFR was lower by 0.97 ml/min/1.73 m2 less (95% CI: -1.93, -0.02) and log(ACR) was lower by an additional 0.15 (95% CI: 0.05, 0.25).

Conclusion:
Among diverse US Hispanic/Latino adults with CKD, higher LE8 score (better cardiovascular health) was associated with a slower decline in eGFR and lower albuminuria over six years.
Pengaruh Penerapan Zonasi Terhadap Pemenuhan Hak Anak Atas Pendidikan Berdasarkan Peraturan Menteri Pendidikan Dan Kebudayaan Nomor 1 Tahun 2021 (Studi Kasus Di SMAN 1 Ungaran)
Authors: Milliano Franzito Risky 
Published: February 2025

Hak anak atas pendidikan merupakan bagian dari Hak Asasi Manusia yang harus diakui secara penuh. Namun zonasi telah merampas kebebasan sebagian anak untuk dapat bersekolah sesuai dengan keinginan dan kemampuannya. Penerapan zonasi tidak membedakan peserta didik berdasarkan kemampuan kognitifnya, setiap peserta didik berhak bersekolah dekat dengan domisili tempat tinggalnya.Penelitian hukum ini dilakukan untuk mengetahui penerapan zonasi dalam memenuhi hak anak atas pendidikan di SMAN 1 Ungaran TA 2023/2024, dan mengetahui faktor pendukung dan penghambat dalam penerapan zonasi sekolah di SMAN 1 Ungaran. Penelitian dilakukan dengan metode kualitatif, dengan spesifikasi penelitian deskriptif-analisis. Objek penelitian ialah terkait pemenuhan hak anak atas pendidikan melalui zonasi di SMAN 1 Ungaran. Teknik pengumpulan data menggunakan dua cara, yaitu wawancara dan studi pustaka.Hasil penelitian yang dilakukan oleh peneliti dapat disimpulkan bahwa penerapan zonasi di SMAN 1 Ungaran : (1) Memiliki dasar hukum penerapan zonasi yang jelas, SMAN 1 Ungaran menerima sebanyak 319 siswa / 74% (tujuh puluh empat persen) dari jalur zonasi. (2) Faktor pendukung mencakup: (1) Regulasi; (2) Pemahaman terhadap hilangnya label ‘Sekolah Favorit’; (3) Kemudahan akses pendaftaran. Faktor Penghambat: (1) Kuota; (2) Kendala sistem PPDB; (3) Tidak meratanya SMAN di Kab. Semarang.
Desain Sistem Monitoring Kelembapan Tanah, Suhu, dan Intensitas Ultraviolet Menggunakan Arduino Mega 2560 Berbasis Internet of Things (IoT)
Authors: Pramono Subur , Ulum Miftahul , Rudiana  , Safitri Ramona Dyah 
Published: February 2025

Kami telah berhasil membangun sistem monitoring kelembapan tanah, pH, suhu, dan intensitas ultraviolet (UV) berbasis Internet of Things (IoT) menggunakan Arduino mega 2560. Sensor yang digunakan untuk mengukur kelembapan tanah, suhu, dan ultraviolet adalah sensor soil moisture, sensor DHT-11, dan sensor GY-ML8511. Aplikasi Node MCU ESP8266 digunakan untuk komunikasi antara Arduino Mega 2560 dan smartphone. Luaran dari sensor kelembapan tanah dihubungkan dengan water pump pada kelembapan di bawah dan blower pada kelembapan di atas 80%. Adapun sensor suhu dan sensor UV hanya digunakan untuk monitoring sistem yang ditinjau. Data intensitas terbesar yang didapatkan menggunakan sensor UV GY-ML8511 adalah dengan nilai ADC sendor 213 dan tegangan 1,01 V. berdasarkan pengujian sistem, didapatkan bahwa sistem berjalan secara optimal
Kualitas Biobriket Variasi Komposisi Tempurung Kelapa, Kulit Kacang Tanah, dan Tinja Sapi sebagai Sumber Energi Alternatif
Authors: Safitri Aan , Sahara Sahara , Jumardin Jumardin 
Published: February 2025

Penelitian fokus pada pengujian biobriket dari komposisi arang tempurung kelapa, kulit kacang tanah, dan tinja sapi dengan perekat tepung kanji. Penelitian ini bertujuan untuk mengetahui kualitas briket yang meliputi parameter kerapatan, kadar air, kadar abu, dan nilai kalor berdasarkan standar SNI. Penelitian ini menggunakan metode karbonisasi untuk tempurung kelapa dan kulit kacang dan pada perlakuan bahan tinja sapi menggunakan metode tanpa karbonisasi. Hasil penelitian menunjukkan bahwa nilai kadar air, kadar abu dan nilai kalor optimal diperoleh pada sampel D masing-masing sebesar 3,5%, 1% dan 5483,26 kal/gram. Untuk pengujian nilai kerapatan briket dari rentang 0,58 gr/𝑐𝑚3 sampai 0,77 gr/𝑐𝑚3. Dari keseluruhan komposisi semuanya memenuhi standar SNI briket dengan sampel terbaik pada komposisi sampel D yang terdiri dari 45% tempurung kelapa, 30% kulit kacang tanah, 15% tinja sapi dan perekat sebanyak 10%.
A Review of Romanian Children’s Literature since the 90s from the Perspective of Moretti’s (Geo)criticism
Authors: Cîrtog Alin C. 
Published: February 2025

Abstract
This article aims to analyze the relationship between Moretti’s theories and methods of critical research and Romanian children’s literature, proposing both a new approach and a new way of reading children’s literature. The main idea is that Romanian children’s literature from the past three decades has become an increasingly developed and effervescent field, with openings towards world literature and, therefore, it needs new research methods pertaining to World Literature studies. Since Franco Moretti’s theories are already integrated into Western (geo)criticism, it is important to metabolize them in the local context precisely in order to legitimize a coherent geocritical approach to Romanian children’s literature.
Effectiveness of the calcification identification and discrimination module incorporated into the computer aided detection system for mammography: the results of the single-center, prospective, randomised study
Authors: Pasynkov D. V. , Romanycheva Е. А. , Egoshin I. A. , Kolchev A. А. , Merinov S. N. , Busygina O. V. 
Published: February 2025

Aim: to develop the module of automated calcification identification (MACI) capable to mark the different types of breast calcifications and suitable for incorporation into the computer-aided detection (CAD) system for mammography, as well as to assess its clinical efficiency.Material and methods. We performed prospective, randomized study included 9078 women who underwent the mammography. All the subjects were randomized (1:1) into the control (CAD) and experimental (CAD + MACI) arms. In the CAD arm the mammography images were processed with the help of CAD MammCheck (with no MACI). In the CAD + MACI arm we used the combined CAD and MACI image processing. After the primary screening completion the subjects were followed for minimum 3 years.Results. During the visual mammography image analysis in the CAD + MACI и CAD arms 170 (3.74%) и 159 (3.50%; р = 0.3716) breast carcinoma (BC) cases were proven, respectively. After the CAD markings analysis we additionally proven 10 and 6 BC cases, respectively (р = 0.8175). During the subsequent MACI markings analysis in the CAD + MACI arm 7 (0.15%) BC cases were verified. Totally, during the primary screening we found 187 and 165 BC cases, respectively (р = 0.0477). During the 3-year follow-up in the CAD + MACI arm 16 BC cases were proven (0.35%), of them in 2 (0.04%) cases the microcalcifications were found in the area of the subsequently verified BC. In the CAD arm the corresponding values were 22 (0.48%) and 9 (0.20%) BC cases (р = 0.054).Conclusion. MACI incorporation into the CAD design significantly increases (5.81%) the detection rate of BC associated with microcalcifications at the expense of small (0.89%) increase of the recall rate.
Perencanaan Lanskap Ekowisata Bendungan Karinga dengan Pendekatan Budaya Sumba Timur
Authors: Wulandari Desi Tri , Franjaya Eduwin Eko , Hutriani Ina Winiastuti 
Published: February 2025

Ekowisata merupakan suatu kegiatan mengunjungi tempat-tempat yang masih alami dan belum tercemari atau terpengaruhi oleh aktivitas manusia, dengan tujuan untuk menikmati pemandangan alam, flora dan fauna, serta budaya masyarakat yang ada, baik dari masa lampau maupun masa kini. Mengacu pada Permendagri Nomor 33 Tahun 2009, bahwa di Sumba Timur terdapat wilayah yang berpotensi untuk dijadikan perwujudan pengembangan destinasi ekowisata yang menarik salah satunya, yaitu kawasan Bendungan Karinga berbasis budaya air. Penelitian ini bertujuan untuk menganalisis potensi serta masalah dalan perencanaan lanskap ekowisata pada Bendungan Karinga, menyusun konsep rencana, dan merencanakan lanskap ekowisata pada Bendungan Karinga dengan pendekatan budaya daerah Sumba Timur. Metode penelitian ini adalah kualitatif – deskriptif Gold yang terdiri dari tahapan persiapan, inventarisasi, analisis, sintesis, dan perencanaan lanskap. Hasil dari penelitian menunjukkan bahwa Kawasan Bendungan Karinga memiliki kendala pada perekonomian masyarakat yang rendah, curah hujan yang rendah, tetapi memiliki potensi alam serta nilai budaya berbasis air. Konsep yang digunakan pada perencanaan lanskap ekowisata Bendungan Karinga yaitu li humba, tana marappu, li karinga. Konsep ini menekankan nilai penting masyarakat, budaya, dan lingkungan Sumba Timur. Perencanaan lanskap yang di olah terdapat tiga rencana struktur untuk pusat kegiatan, yaitu : zona marappu wanno (penerima), zona li humba (budaya) dan zona tana beri ina mu (konservasi).
Authors: Yasa I Ketut Gede Udha Krisna , Dwidasmara Ida Bagus Gede , Arya Kadyanan I Gusti Agung Gede 
Published: February 2025

Alat musik tradisional merupakan salah satu wujud representasi identitas budaya dari tiap-tiap daerah. Alat musik tradisional diciptakan dalam bentuk dan fungsi yang berbeda-beda dalam setiap penggunaannya. Kegiatan memainkan alat musik tradisional bagi masyarakat merupakan salah satu bentuk kesenian yang lahir dari dalam diri. Kesenian itu sendiri merupakan salah satu warisan budaya, yang lebih dikenal dengan kesenian daerah yang secara turun temurun diwariskan. Alat musik tradisional memiliki ciri khasnya masing-masing seperti contoh alat musik Kendang Bali. Kendang bali merupakan salah satu instrumen musik yang sangat erat kaitannya dengan seni karawitan. Seni karawitan secara singkat adalah seni suara dengan mengolah bunyi benda atau alat musik (instrumen) secara gamelan tradisional. Kendang dimainkan dengan cara ditepak menggunakan telapak tangan. Instrumen kendang termasuk ke dalam golongan madya, yang berfungsi sebagai pemimpin dari sebuah barungan gamelan. Di Bali instrumen kendang biasanya dimainkan secara berpasangan dan individu. Jika dimainkan secara berpasangan maka kendang itu dinamakan kendang lanang dan wadon. Di era yang serba digital seperti sekarang ini banyak masyarakat khususnya masyarakat Bali hanya sebatas mengenal istilah kendang bali tanpa mengetahui jenis atau makna lain yang terkandung di dalamnya. Seiring perkembangan zaman, banyak masyarakat yg lebih tertarik dengan alat musik modern sehingga alat musik tradisional perlahan mulai dilupakan. Penggunaan ontologi sebagai teknik dokumentasi atau representasi ini menjadi solusi dalam permasalahan ini, Ontologi dalam web semantik adalah sebuah katalog dimana skema yang dibuat menggunakan ontologi. Ontologi diperlukan karena berguna untuk meningkatkan pengembangan aplikasi web semantic. Ontologi untuk warisan budaya daerah Bali, instrumen atau gamelan Bali khususnya Kendang Bali, dapat digunakan untuk mendokumentasikan dan merepresentasikan pengetahuan yang melingkupi domain Kendang Bali dan juga membuat pengetahuan tentang Kendang Bali tidak hanya secara tacit namun secara eksplisit.
PENERAPAN MARKETING MIX UNIVERSITAS WIRARAJA DALAM UPAYA MENINGKATKAN MINAT MAHASISWA BARU
Authors: Wijaya Nur Qoudri 
Published: February 2025

The development of science and technology requires people to make the changes so that they can keep abreast of the times. The role of knowledge is significant for any society that wants to improve its ability to follow the competitive rivalry in the multidimensional crisis. Thus, Wiraraja University as a Higher Education institution has a task that is noteasy, it needs a good management system. This is so that educational institutions become one of the services in the field of education that has contributed to the development of the Nation and State. This research aims to analyzes the factors supporting and inhibiting factors as well as the concept of Marketing Mix to increase interest in new students at the University Wiraraja Sumenep. This research is descriptive quantitative research, the technique used in data collection are interviews, observation, Documentation and the questionnaire.The results of the group of dataare analyzed using methodsForce Field Analysis. Marketing Mix in the University Wiraraja in an effort to increase student interest in new approaches 7 P yaituProduct (products), Price (price), people (human resources), Place (location / place), Promotion (promotion), Physical Evidence (Physical Infrastructure) , Proces (Service) has not run optimally. Need for strategy development to increase interest in new students, skill soft equip the students, increased educational qualifications for lecturers, do not raise the cost of education, the provision of entrepreneurial provision for students. And to increase the number of new students is required new student recruitment agency aims to increase the number of new students.
μ-Centralizers with Commutativity Results of Prime and Semiprime Γ-Rings
Authors: Ahmad Maalim Salam , Majeed Abdulrahman H. 
Published: February 2025

Let A be a 2- torsion free prime Γ- ring, and L be a square closed Lie ideal of A i.e. xβx∈L for all x∈L and β∈Γ, suppose that μ is an endomorphism of A, and f is a right μ- centralizer which is not the identity map on L, satisfying f([x, b]_γ )=〖∓[x,b]〗_γ ( or f(xδr)=∓xδr) for all x,b∈L , γ∈Γ, then L⊆Z(A).
R*-Small Submodules and -Hollow Modules
Authors: Jasim Mustafa Mohammed , Khalid Wasan 
Published: February 2025

The purpose of this study is to present a new concepts on a module M over a ring, these concepts is called R*-small sub module, R*-hollow module which present generalizations of the small submodule and hollow module, respectively. Key characteristics of these concepts such as the image and direct sum of R*-small sub module, R*-hollow module are R*-small submodule, R*-hollow submodule, respectively.
Socio-demographic, exercise, and anthropometric profiles of adults participating in fitness exercise programs in Vhembe district, Limpopo province, South Africa
Authors: Ramashidzha Rendani Raymond , Makuse Sefora Hazel , Masoga Sylven 
Published: February 2025

Introduction Adults in Vhembe district participate in fitness exercise programs for optimal health. However, the nutritional profiles of these participants remain unknown.
Aim: To assess the socio-demography, calculate BMI and measure WC of adults participating in fitness exercise programs around Vhembe district, Limpopo Province.
Method: A cross–sectional study design was conducted to assess socio-demographic and anthropometric profiles of 112 adults participating in fitness exercise programs around Vhembe district, Limpopo Province. Ethical clearance was obtained from TREC and written consent by the participants. Socio-demographic profile included, for example, age, education status, duration and frequency of training. Anthropometry included weight and height to calculate BMI, and waist circumference. Data were analyzed using SPSS (v29). The Chi-square test, with a p-value of <0.05, was used to determine the association among variables.
Results: Males were aged 36.3±9.3 and females 32.1±8.7 years; training three times per week for two hours in aerobics and bodybuilding programs. Most participants had bachelor’s degrees (males, 35.5%; females, 29.8%) and diplomas (males, 32.3%; females, 27.7%). Unemployment was higher (57.4%) among females compared to males (38.5%). Aerobic participants were overweight (males, 27.8±4.7; females 28.8±4.8 kg/m²) whereas those in bodybuilding were obese (31.0±16.9, males and 37.5±0.0 kg/m², females). Participants in both programs had optimal waist circumferences (<102 cm, males and <88 cm, females). Anthropometry was associated (p<0.05) to demography among the aerobic exercise participants.
Conclusion: Participants trained once per day, three times a week for two hours. The majority had higher education qualifications, however, unemployed. Participants were overweight with acceptable waist circumference values
The link between serum vitamin D levels and bronchial asthma: A case control study
Authors: Kumar Pavan N , Amirullah Amirullah , Kumar R Deepak 
Published: February 2025

Objectives
Asthma is a common long-term respiratory condition that considerably increases morbidity worldwide. Because of its immunomodulatory properties, vitamin D may have an impact on the severity of asthma. This case control study explores the relationship between serum vitamin D levels and bronchial asthma.

Material and Methods
There were 70 participants in all, 35 of whom were matched controls and 35 of whom were asthma patients. Measurements of IgE and serum vitamin D were made to look for associations with asthma.

Results
Patients with asthma had higher IgE levels, suggesting heightened allergic reaction and substantially less vitamin D in their blood (13.83 ± 9.34 ng/mL) than control (27.34 ± 8.19 ng/mL) (p < 0.001).

Conclusion
This study highlights that individuals with bronchial asthma tend to have lower serum vitamin D levels and higher IgE levels, suggesting a link between vitamin D deficiency and asthma severity. Addressing vitamin D deficiency may offer a supportive role in asthma management, though further studies are needed to confirm these findings.