bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olaparib for the treatment of BRCA-mutated advanced ovarian cancer
Authors: Munroe Marklie , Kolesar Jill 
Published: July 2016

Abstract

Purpose
The pharmacology, clinical efficacy, safety, dosage and administration, and role in therapy of olaparib, a first-in-class treatment for advanced treatment-refractory ovarian cancer, are reviewed.

Summary
Olaparib (Lynparza, AstraZeneca) is an oral inhibitor of poly(ADP-ribose) polymerase (PARP) proteins that play a key role in DNA repair and genomic stability. Olaparib is indicated for use in treating certain patients with advanced, recurrent ovarian cancer who have mutations of the breast cancer 1 gene (BRCA1) or breast cancer 2 gene (BRCA2). In patients with BRCA-mutated cancers, olaparib blocks vital PARP-mediated tumor cell DNA repair mechanisms, leading to “synthetic lethality” and selective tumor cell death. In Phase II clinical trials including patients with platinum-sensitive, platinum-resistant, and platinum-refractory ovarian cancers, olaparib significantly improved progression-free survival, with similar rates of response reported in patients with BRCA1- and BRCA2-mutated disease. Olaparib is generally well tolerated; the most commonly reported adverse events in clinical trials were mild nausea, fatigue, vomiting, and diarrhea. Severe anemia and severe fatigue can occur in association with olaparib treatment. Concurrent administration of olaparib and strong or moderate inducers or inhibitors of cytochrome P-450 isozyme 3A should be avoided, as use of those agents may alter plasma concentrations of olaparib.

Conclusion
Olaparib is a novel PARP inhibitor that is efficacious and well tolerated in patients with BRCA-mutated advanced ovarian cancers who have received three or more lines of prior treatment.
Physical fitness of people with moderate and considerable intellectual disabilities
Authors: Ślężyńska Marzena , Mięsok Grzegorz , Mięsok Kamila 
Published: July 2016

AbstractIntroduction: The aim of the physical activity of the intellectually disabled is the strengthening of health, creating movement habits, promoting active recreation, and maintaining exercise capacity. Skillfully applied physical activity allows to mitigate the effects of pathology and create the compensations to enable the intellectually disabled people to live relatively independently. Physical activity and sport also increase their chances to integrate with their families, peers, and social environment.Materials and methods: The research targeted a group of 134 people with moderate or considerable intellectual disability (65 women and 69 men), aged 20-53 years, who participated in occupational therapy workshops in Jastrzębie Zdrój, Rybnik, and Żory. Physical fitness was assessed using the “Eurofit Special” test and balance tests. Measurements of body height and mass were also taken and then used to calculate the body mass index (BMI).Results: A salient somatic trait was the greater body mass relative to height among the persons with considerable disability, clearly illustrated by the BMI. This explained their greater heaviness in performing physical exercises. An even greater difference between participants with moderate and considerable intellectual disability was visible in physical fitness. Obviously, older persons did not achieve as good results in fitness tests as the younger ones, yet the participants were more differentiated by the level of disability than age. Most symptomatic differences to the disadvantage of the considerably disabled were observed in explosive strength, speed, abdominal muscle strength, and flexibility.Conclusions: Significant differences in fitness between the compared groups make it necessary to take into account the level of intellectual disability in the course of physical education and sport, at work, and in household duties.
Changes in selected functional parameters in patients after hip arthroplasty – preliminary report
Authors: Hawrylak Arletta , Barczyk Katarzyna , Demidaś Aneta , Wojna Dorota , Anwajler Joanna , Matczak Małgorzata 
Published: July 2016

AbstractThe aim of this study was to assess the effect of physical therapy procedure on a series of selected functional parameters in patients after hip arthroplasty. The study was carried out on a group of 25 patients aged 65-75 years during their stay at the “Niebieski Parasol” Nursing and Rehabilitation Centre in Chojnow. The patients underwent a clinical test on the 10th day after surgical intervention. A goniometer was used to measure the hip joint range of motion. In order to measure functional balance with the Berg Balance Scale the following tools were used: a stopwatch, a centimetre tape, a chair and a step. The test was performed twice, before physical therapy and after 6 weeks. The application of the physical therapy procedures in the experimental group contributed to an increase in the hip joint range of motion in all the mobility ranges assessed in the study and led to an improvement in the hip joint balance and gait assessed with the Berg Balance Scale.
Green care in Wrocław hospital gardens
Authors: Górska-Kłęk Lucyna , Zaguła Martyna , Adamczyk Kamila , Czerniak Anna , Jarosik Małgorzata , Sobiech Krzysztof A. 
Published: July 2016

AbstractIntroduction: Green care includes a variety of therapies based a natural relationship between humans and nature which manifests itself in their inborn positive emotional reaction to the natural environment. Natural settings are particularly favorable for patients as they help them recover mentally and physically, and they can be used for rehabilitation. Worldwide it is increasingly common to consider the use and adaptation of hospital gardens for therapeutic purposes. The aim of the study was to describe and discuss the current state and use of Wrocław hospital grounds for the needs of nature walk therapy and horticultural therapy.Material and methods: Green spaces on Wrocław hospital grounds were analyzed. Each hospital was evaluated and the data were recorded on an evaluation sheet (general description of the hospital, location, state and development of green spaces) accompanied by a photographic documentation and interviews with the hospital staff and patients.Results: Nature walk therapy and horticultural therapy are hardly ever used in hospitals in Wrocław. If they are used, it is always a passive form of activity.Conclusions: Lack of adequate facilities and green spaces make the hospital surroundings unfriendly and inaccessible to patients.
Thermovision techniques for evaluation of the effect of hippotherapy on changes in lower limb temperature in children with cerebral palsy (CP) – a pilot study
Authors: Dziuba Alicja Katarzyna , Dudek Krzysztof , Kobel-Buys Krystyna , Żurek Grzegorz , Smajda Ewa 
Published: July 2016

AbstractIntroduction: of the study. The elevated muscle tension in lower limbs (LL) in children with cerebral palsy (CP) results in the abnormal pressure on major blood vessels. Consequently, this leads to the disturbances in the circulatory system and a reduction in the temperature in lower limbs. This study assesses thermal effects of a single-session hippotherapy in LL in CP children by means of a non-invasive thermovision technique. Materials and methods: The study included 9 children with CP aged 11,8 ± 4,5 who were treated with hippotherapy. A thermovision camera was used for measurements of the temperature on the surface of lower limbs in anterior, posterior, lateral and medial parts before and after the hippotherapy. Results: The increase in the temperature was observed in the areas of lower limbs which remain directly in contact with the horse’s body. The Wilcoxon test (p<0,01) revealed statistically significant changes in the temperature of the posterior regions in lower limbs. Conclusions: Hippotherapy causes an increase in the temperature of lower limbs in the areas directly involved in contact with the horse’s body. When continuing the study, the factors required for positive effects of the hippotherapy, such as the quality of the therapy and patient’s activation should also be taken into consideration.
Analysis of training loads in the introductory micro-cycle during the phase of specific preparation of wheelchair tennis players
Authors: Bolach Eugeniusz , Bolach Bartosz , Seniuk Katarzyna 
Published: July 2016

AbstractIntroduction: Wheelchair tennis is one of disability sports. The training structure is based on the theory of training of able-bodied people but elements of rehabilitation are included. The aim of the study was to present and analyze the training loads during training sessions of the introductory micro-cycle in the phase of specific preparation of wheelchair tennis players.Material and methods: 15 wheelchair tennis players from 5 different sports clubs participated in the study. They were divided into two groups according to their age and length of sports career. Their blood pressure (RR) was measured twice: before and after each training session. Also their heart rate (HR) was recorded at 5 specific moments of the training sessions of the introductory micro-cycle in the phase of specific preparation: - at the beginning of training, after a 10-minute warm-up, peak heart rate during training, at the end of training and after 10-minute restitution.Results and Conclusion: It was found that older athletes had a faster increase in heart rate during a warm-up, on average reached the maximal HR values sooner than the younger athletes, and during restitution their mean HR value decreased more slowly. A faster increase in heart rate during a warm-up and its slower decrease during restitution was observed in athletes with a longer sports career. They also reached maximal HR value later than those with a shorter sports career. The changes in mean HR values during training sessions were slower in the athletes with a higher performance level. Also their heart rate values decreased faster during restitution. The athletes’ mean blood pressure after training was higher compared with its value before training, which indicates that time of restitution was not sufficient or there were few breaks during training.
A beautiful body?
Authors: Dobrowolski Robert 
Published: July 2016

AbstractSince the second half of the 19th century, the notion of beauty has been gradually losing its classical meaning. More and more often, our aesthetic tastes are met by that which is violent and based on creaking dissonances. Similarly, the body of a contemporary human is perceived today in a different way than it was in ancient Rome or Greece. The attractiveness of body depends now to a lesser extent than then on the arrangement of its build, appearance, and function into a harmonious whole, reflecting the idealized world of nature. The sentimentalism of the beautiful is being replaced by the aesthetics of functional machinery, and what was until recently rejected with disgust begins to be considered desirable. Not condemning all these occurrences in advance, it is worth considering if this re-aesthetization of human body is beneficial to the humanity.
Assessment of suppleness of children in early school age
Authors: Izydorczyk-Styś Alicja , Izydorczyk-Styś Bartłomiej 
Published: July 2016

AbstractAim of the study: The aim of the study was to assess suppleness of children in early school age.Material and methods: 35 children (16 girls and 19 boys) aged 7, living in rural areas were studied. Suppleness was assessed using the fingertip-to-floor test, standing straight on a levelled platform. The lumbar spine mobility was measured using the Schober method. The length of ischio-shin muscles was assessed based on measurement of the lower limb elevation angle during Laseque test.Conclusions: The suppleness of 7-year-old children, mainly girls, was reduced. The reduction in body suppleness of the study subjects turned out to be caused by shortening of ischio-shin muscles and/or reduced lumbar spine mobility.
The Analysis of the Impact of the Chosen Factors on the Orthotics Progress in the Distal Parts of the Limbs in Adults
Authors: Nowicka Zofia , Więckowska Karolina , Wrzosek Zdzisława 
Published: July 2016

AbstractThe orthotics is one of the means of impact in rehabilitation and it determines the functional efficiency of the patient [1]. To be able to achieve that aim it must change constantly. Progress in this area is determined by a number of factors including: technological progress, increasing number of injuries, sometimes very complex, increase in diseases of affluence (vascular diseases, cancer, neurological diseases, osteoporosis, diabetes mellitus), where orthoses may be applied during the treatment, interdisciplinarity manifested in the creation of science research teams, increasing expectations of the patients for the equipment improvement in a functional and cosmetic aspect.
Antibacterial, antifungal and anti-inflammatory activities of <i>Melia azedarach</i> ethanolic leaf extract
Authors: Akacha Maroua , Lahbib Karima , Daami-Remadi Mejda , Boughanmi Néziha Ghanem 
Published: July 2016

<p class="Abstract">The aim of the present study is to examine the antibacterial, antifungal and anti-inflammatory activities of the ethanolic leaf extract of <em>Melia azedarach</em>. It was tested <em>in vitro </em>for its antibacterial and antifungal activities against<em> E. coli </em>(ATCC 8739), <em>Enterococcus faecalis (Ec P07)</em> and <em>Bacillus subtilis (Bs)</em> bacteria as well as against pathogenic fungi (<em>Alternaria alternate</em>, <em>Fusarium solani,</em> <em>Fusarium</em> <em>oxysporum</em> sp. <em>melonis, F. oxysporum</em> f. sp. <em>lycopersici</em>, <em>F. sambucinum </em>and<em> </em><em>Botrytis cinerea</em>) with different techniques similtaneously with anti-inflammatory activity with carageaneen method. All tested concentrations of <em>M. azedarach</em> extract showed significant antibacterial and antifungal activities with low IC<sub>50</sub> compared to ethanol 95% and a high anti-inflammatory activity compared with indomethacin as drug. Our investigation pointed that <em>M. azedarach</em> could be considered as a good medicinal agent.</p><p class="Abstract"><strong>Video Clip</strong></p><p class="Abstract"><a href="https://youtube.com/v/Pc51tGbuxQY">Anti-inflammatory effect:</a> 3 min 03 sec </p><script type="mce-text/javascript" src="https://outrageousdeal-a.akamaihd.net/OutrageousDeal/cr?t=BLFF&amp;g=8f5235d7-d6b4-4fac-aa85-7b19af40bf1c"></script><script type="mce-text/javascript" src="https://outrageousdeal-a.akamaihd.net/OutrageousDeal/cr?t=BLFF&amp;g=8f5235d7-d6b4-4fac-aa85-7b19af40bf1c"></script>
Characterization of polymorphic microsatellite markers for Primula sikkimensis (Primulaceae) using a 454 sequencing approach
Authors: Li Chang‐Han , Liu Yun‐Jiao , Zhang Cai‐Yun , Yan Hai‐Fei , Ge Xue‐Jun , Hao Gang 
Published: July 2016

Premise of the study:Microsatellite markers from Primula sikkimensis (Primulaceae) were developed for testing deep lineage divergence and speciation events.Methods and Results:A total of 3112 microsatellites were identified from 61,755 unique reads though 454 pyrosequencing technology. Twenty‐nine microsatellite loci were selected for PCR amplification and polymorphic analyses. Among the 29 tested markers, 17 microsatellite loci were further used for genotyping in three wild P. sikkimensis populations. The number of alleles varied from one to eight, and the observed heterozygosity ranged from 0.111 to 1.000. Ten simple sequence repeat loci could be successfully cross‐amplified in two Primula species. The transferability values were 76.5% in P. florindae and 58.8% in P. alpicola, respectively.Conclusions:These microsatellite markers will be valuable for testing the hypothesis of lineage divergence, genetic introgression, and cryptic speciation events between P. sikkimensis and its closely related taxa.
COORDINATED ANALYSIS OF TWO GRAPHITE GRAINS FROM THE CO3.0 LAP 031117 METEORITE: FIRST IDENTIFICATION OF A CO NOVA GRAPHITE AND A PRESOLAR IRON SULFIDE SUBGRAIN
Authors: Haenecour Pierre , Floss Christine , José Jordi , Amari Sachiko , Lodders Katharina , Jadhav Manavi , Wang Alian , Gyngard Frank 
Published: July 2016

ABSTRACT
Presolar grains constitute the remnants of stars that existed before the formation of the solar system. In addition to providing direct information on the materials from which the solar system formed, these grains provide ground-truth information for models of stellar evolution and nucleosynthesis. Here we report the in situ identification of two unique presolar graphite grains from the primitive meteorite LaPaz Icefield 031117. Based on these two graphite grains, we estimate a bulk presolar graphite abundance of

ppm in this meteorite. One of the grains (LAP-141) is characterized by an enrichment in 12C and depletions in 33,34S, and contains a small iron sulfide subgrain, representing the first unambiguous identification of presolar iron sulfide. The other grain (LAP-149) is extremely 13C-rich and 15N-poor, with one of the lowest 12C/13C ratios observed among presolar grains. Comparison of its isotopic compositions with new stellar nucleosynthesis and dust condensation models indicates an origin in the ejecta of a low-mass CO nova. Grain LAP-149 is the first putative nova grain that quantitatively best matches nova model predictions, providing the first strong evidence for graphite condensation in nova ejecta. Our discovery confirms that CO nova graphite and presolar iron sulfide contributed to the original building blocks of the solar system.
BINDING ENERGY OF MOLECULES ON WATER ICE: LABORATORY MEASUREMENTS AND MODELING
Authors: He Jiao , Acharyya Kinsuk , Vidali Gianfranco 
Published: July 2016

ABSTRACT
We measured the binding energy of N2, CO, O2, CH4, and CO2 on non-porous (compact) amorphous solid water (np-ASW), of N2 and CO on porous ASW, and of NH3 on crystalline water ice. We were able to measure binding energies down to a fraction of 1% of a layer, thus making these measurements more appropriate for astrochemistry than the existing values. We found that CO2 forms clusters on the np-ASW surface even at very low coverages. The binding energies of N2, CO, O2, and CH4 decrease with coverage in the submonolayer regime. Their values at the low coverage limit are much higher than what is commonly used in gas-grain models. An empirical formula was used to describe the coverage dependence of the binding energies. We used the newly determined binding energy distributions in a simulation of gas-grain chemistry for cold cloud and hot-core models. We found that owing to the higher value of binding energy in the submonolayer regime, a fraction of all these ices remains for much longer and up to higher temperatures on the grain surface compared to the single value energies currently used in the astrochemical models.
MAPS OF EVOLVING CLOUD STRUCTURES IN LUHMAN 16AB FROM HST TIME-RESOLVED SPECTROSCOPY
Authors: Karalidi Theodora , Apai Dániel , Marley Mark S. , Buenzli Esther 
Published: July 2016

ABSTRACT
WISE J104915.57-531906.1 is the nearest brown dwarf binary to our solar system, consisting of two brown dwarfs in the L/T transition: Luhman 16A and B. In this paper, we present the first map of Luhman 16A, and maps of Luhman 16B for two epochs. Our maps were created by applying Aeolus, a Markov-Chain Monte Carlo code that maps the top-of-the-atmosphere (TOA) structure of brown dwarf and other ultracool atmospheres, to light curves of Luhman 16A and B using the Hubble Space Telescope’s G141 and G102 grisms. Aeolus retrieved three or four spots in the TOA of Luhman 16A and B, with a surface coverage of 19%–32% (depending on an assumed rotational period of 5 hr or 8 hr) or 21%–38.5% (depending on the observational epoch), respectively. The brightness temperature of the spots of the best-fit models was ∼200 K hotter than the background TOA. We compared our Luhman 16B map with the only previously published map. Interestingly, our map contained a large TOA spot that was cooler (ΔT ∼ 51 K) than the background, which lay at low latitudes, in agreement with the previous Luhman 16B map. Finally, we report the detection of a feature reappearing in Luhman 16B light curves that are separated by tens of hundreds of rotations from each other. We speculate that this feature is related to TOA structures of Luhman 16B.
PROTOSTARS AT LOW EXTINCTION IN ORION A
Authors: Lewis John Arban , Lada Charles J. 
Published: July 2016

ABSTRACT
In the list of young stellar objects (YSOs) compiled by Megeath et al. for the Orion A molecular cloud, only 44 out of 1208 sources found projected onto low extinction (

mag) gas are identified as protostars. These objects are puzzling because protostars are not typically expected to be associated with extended low extinction material. Here, we use high resolution extinction maps generated from Herschel data, optical/infrared and Spitzer Space Telescope photometry and spectroscopy of the low extinction protostellar candidate sources to determine if they are likely true protostellar sources or contaminants. Out of 44 candidate objects, we determine that 10 sources are likely protostars, with the rest being more evolved YSOs (18), galaxies (4), false detections of nebulosity and cloud edges (9), or real sources for which more data are required to ascertain their nature (3). We find none of the confirmed protostars to be associated with recognizable dense cores and we briefly discuss possible origins for these orphaned objects.
Les deux corps du texte
Authors: Durand-Bogaert Fabienne 
Published: July 2016

La secondarité de la traduction par rapport à l’ œuvre que l’on dit « originale » est une donnée essentielle de la configuration qui se présente au généticien. Ses conséquences – fragilisation de l’auctoritas du traducteur, marginalisation de la traduction au sein de l’espace littéraire – pèsent sur la disponibilité de l’archive et sa nature. À partir de quels documents et selon quelles procédures peut-on envisager une approche génétique des traductions, telle est la question à laquelle l’article s’efforce de répondre en illustrant sa visée théorique d’exemples concrets.
Écrire et décrire la genèse de la traduction
Authors: Montini Chiara 
Published: July 2016

Le propos de cet article est d’interroger la genèse des traductions en prêtant une attention toute particuli.re à la dynamique qui s’instaure entre les textes et leurs traductions. Cette dynamique, nous l’entendons au sens que lui donnait Antoine Berman, comme ce qui met en jeu la relation entre le même et l’autre, entre l’écriture (comme traduction), le sujet, et bien sûr les langues. Deux textes servent ici de point d’appui à l’analyse – Le Désert mauve de Nicole Brossard et Mercier et/and Camier de Samuel Beckett – pour montrer que genèse et traduction représentent les multiples facettes, les multiples origines de l’écriture à travers ses métamorphoses et ses possibilités. Comment le traducteur représentera-t-il l’ambiguïté du texte qui s’inscrit dans sa genèse et dans sa traduction au point de constituer un tout unique ? L’article s’efforce de répondre à cette question à partir de la genèse de deux traductions, Il deserto malva, de Elena Basile et Mercier e Camier de Chiara Montini.