bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival Dynamics of Invasive Fungal Diseases in Pediatric Hemato-Oncology Patients at a Tertiary Medical Facility in Mexico from July 2020 to July 2023
Authors: V Ariana Ordoñez , H Miguel Minero , Ordoñez Javier , G Itzel Villanueva , Morayta Alfredo R 
Published: October 2024

Abstract

Background
Invasive fungal diseases (IFD) have been increasing in prevalence over the past two decades, with filamentous fungi being the most common cause. However, candidiasis remains the predominant etiology of infection, especially in cases of neutropenic fever accompanied by neutropenic colitis. The prevalence of infections caused by Aspergillus species, Mucor species, Fusarium, and other species is higher among individuals with severe and extended neutropenia and those who have undergone hematopoietic progenitor cell transplantation.

Methods
A retrospective, descriptive, observational study was conducted to identify cases of patients diagnosed with invasive fungal diseases, categorizing them as possible, probable, or confirmed. In our comprehensive analysis of cases, we prioritize the examination of diseases induced by filamentous fungi, while considering the specific chemotherapy regimen administered and the particular oncological condition.

Results
The predominant etiology observed was invasive aspergillosis, followed by mucormycosis. A total of 18 cases suggestive of invasive Aspergillosis were identified, but clinical or histopathological investigations were not conducted due to limitations. The majority of cases were pulmonary, accounting for 92% of cases, while rhinosinusal involvement was identified in 8%. Factors such as clinical characteristics, imaging studies, serum galactomannan determination, and microbiological culture were considered. The patient survival rate was found to be 86.7%, with an average treatment duration of six weeks. A mortality rate of 3.7% was observed due to the underlying disease during the consolidation phase of invasive fungal diseases.

Conclusion
In our study, invasive aspergillosis emerged as the predominant invasive fungal disease in pediatric hemato-oncology patients. Despite challenges in conducting comprehensive investigations, our findings underscore the importance of timely diagnosis and management. The 86.7% survival rate reflects the efficacy of the treatment approach employed, while the observed mortality emphasizes the impact of underlying diseases on outcomes. This study contributes valuable insights to the understanding and improvement of survival dynamics in pediatric patients facing invasive fungal diseases.
Extending the Dixon and Coles model: an application to women’s football data
Authors: Michels Rouven , Ötting Marius , Karlis Dimitris 
Published: October 2024

Abstract
The prevalent model by Dixon and Coles extends the double Poisson model where two independent Poisson distributions model the number of goals scored by each team by moving probabilities between the scores 0-0, 0-1, 1-0, and 1-1. We show that this is a special case of a multiplicative model known as the Sarmanov family. Based on this family, we create more suitable models by moving probabilities between scores and employing other discrete distributions. We apply the new models to women’s football scores, which exhibit some characteristics different than that of men’s football.
Effective percutaneous treatment of severe necrotizing pancreatitis: a case report
Authors: Asenov Yavor , Vasilev Ivan , Sedloev Theophyl , Penkov Nikolay , Kunev Boris 
Published: October 2024

Abstract
Necrotizing pancreatitis (NP) is a severe form of acute pancreatitis associated with high morbidity and mortality. The management of infected necrotizing pancreatitis (INP) has evolved from open surgical necrectomy to minimally invasive techniques, such as percutaneous catheter drainage (PCD). We report the case of a 71-year-old male with a history of cholelithiasis who presented with acute abdominal pain, nausea, and vomiting. Initial imaging revealed an enlarged pancreas with peripancreatic fluid collections. Conservative treatment improved his condition, but nine days later signs of sepsis, including a persistent fever were presented. Computed tomography (CT) verified several large gas-containing fluid collections spreading from the pancreas to the left iliac crest along with bilateral pleural effusions. The patient underwent PCD with multiple drains inserted. Microbiological analysis showed Meropenem-resistant E. coli, leading to a change in antibiotic therapy. Follow-up imaging confirmed the resolution of fluid collections, and the patient recovered without requiring laparotomy. PCD has emerged as a crucial component of the step-up approach in managing INP. Compared with open necrectomy, PCD offers lower mortality and morbidity rates. The PAncreatitis, Necrosectomy versus sTEp up appRoach (PANTER) trial and subsequent studies have validated the efficacy of PCD, demonstrating its ability to reduce complications and healthcare costs while improving patient outcomes. PCD is a safe and effective treatment for INP, representing a valuable alternative to traditional surgical methods. This case underscores the importance of minimally invasive strategies in the management of NP.
Early surgical intervention is critical for strangulated Richter’s hernia
Authors: Smith Christopher R , Chatzikonstantinou Michail 
Published: October 2024

Abstract
Richter’s hernia is a rare but serious surgical emergency involving the entrapment or strangulation of part of the bowel’s circumference in the hernial orifice, often without causing complete luminal obstruction. This case report describes a man in his 70s presenting with a 3-day history of abdominal pain and vomiting, despite normal bowel movements. Blood results revealed raised inflammatory markers, and computed tomography imaging suggested small bowel obstruction due to an incarcerated left inguinal hernia. Emergency surgery confirmed a Richter’s hernia with a strangulated but viable bowel loop. Early surgical intervention led to a positive outcome. This case underscores the importance of high suspicion, early referral, and timely imaging in managing Richter’s hernia to prevent severe complications, such as gangrene and perforation. Despite the absence of obstructive symptoms, early surgical intervention is critical when there is clinical concern regarding strangulation.
A simple model of globally magnetized accretion discs
Authors: Begelman Mitchell C 
Published: October 2024

ABSTRACT
We present an analytic, quasi-local model for accretion discs threaded by net, vertical magnetic flux. In a simple slab geometry and ignoring stochastic mean-field dynamo effects, we calculate the large-scale field resulting from the balance between kinematic field amplification and turbulent diffusion. The ability of the disc to accumulate magnetic flux is sensitive to a single parameter dependent on the ratio of the vertical diffusion time to the Alfvén crossing time, and we show how the saturation levels of magnetorotational and other instabilities can govern disc structure and evolution. Under wide-ranging conditions, inflow is governed by large-scale magnetic stresses rather than internal viscous stress. We present models of such ‘magnetically boosted’ discs and show that they lack a radiation pressure-dominated zone. Our model can account for ‘magnetically elevated’ discs as well as instances of midplane outflow and field reversals with height that have been seen in some global simulations. Using the time-dependent features of our model, we find that the incorporation of global transport effects into disc structure can lead to steady or episodic ‘magnetically arrested discs’ that maximize the concentration of magnetic flux in their central regions.
Decoding the early Universe: exploring a merger scenario for the high-redshift cluster JKCS041 using numerical models
Authors: Felix Sharon , Gogoi Antareep , Shavelle Kaitlyn , Sike Brandon , King Lindsay , Andreon Stefano , Chadayammuri Urmila , ZuHone John , Romero Charles 
Published: October 2024

ABSTRACT
JKCS041 ($z=1.8$) is one of the most distant galaxy cluster systems known, seen when the Universe was less than 4 billion years old. Recent Sunyaev–Zeldovich (SZ) observations show a temperature decrement that is less than expected based on mass estimates of the system from X-ray, weak gravitational lensing, and galaxy richness measurements. In this paper, we seek to explain the observables – in particular the low SZ decrement and single SZ peak, the projected offset between the X-ray and SZ peaks of $\approx$220 kpc, the gas mass measurements and the lensing mass estimate. We use the gamer-2 hydrodynamic code to carry out idealized numerical simulations of cluster mergers and compare resulting synthetic maps with the observational data. Generically, a merger process is necessary to reproduce the observed offset between the SZ and X-ray peaks. From our exploration of parameter space, seen a few tenths of a Gyr after first core passage, two components with total mass of $\approx 2\times 10^{14} \,\text{M}_\odot$, mass ratio of $\approx$2:3, gas fraction of $0.05-0.1$, and Navarro, Frenk and White mass density profile concentrations c$\approx$ 5 are scenarios that are consistent with the observational data. For consistency with the SZ and X-ray measurements, our simulations exclude total mass in excess of $\approx 3\times 10^{14} {\rm M}_{\odot }$, primarily based on the SZ signal. The mass ratio is constrained by the SZ–X-ray offset and magnitude of the SZ signal, ruling out systems with equal and vastly different masses.
Isolated central nervous system lymphomatoid granulomatosis in an older adult patient with systematic lupus erythematosus: A case report
Authors: Kambe Takayuki , Yamaguchi Makoto , Katsuno Takayuki , Sugiyama Hirokazu , Kamiya Keisuke , Imai Kentaro , Kinashi Hiroshi , Banno Shogo , Ito Yasuhiko , Ishimoto Takuji 
Published: October 2024

ABSTRACT
Lymphomatoid granulomatosis (LYG) is a rare, T-cell-rich Epstein–Barr virus (EBV)-positive B-cell lymphoproliferative systemic disease. Only a few cases of LYG have been described in patients with autoimmune disorders, with only one case described in a patient with systemic lupus erythematosus (SLE). However, no cases of isolated central nervous system (CNS)–LYG have been reported in patients with autoimmune diseases. Since isolated CNS involvement is rare, its clinicopathological features remain incompletely understood. Herein, we report about an 85-year-old Japanese woman who was diagnosed with SLE 26 years ago and was stable and maintained on prednisone (5 mg/day) for 20 years. Twenty-six days before admission, she developed cognitive dysfunction. Brain magnetic resonance imaging (MRI) revealed multiple nodular lesions with ring-like enhancements seen on gadolinium-enhanced T1-weighted imaging. A brain biopsy was performed on the right frontal lobe lesion. Pathological findings revealed T-cell infiltration surrounding the blood vessels with fibrin deposition, a few multinucleated cells, and large atypical cells with prominent nucleoli. Large atypical cells positive for CD20 and EBV-encoded RNA were seen at a density of &gt;100 cells per high-power field. Based on laboratory testing, imaging, and pathology findings, the patient was diagnosed with Grade III LYG. Treatment with tirabrutinib (480 mg once daily) was started. The patient achieved clinical response to treatment, as evidenced by improved mental status. In patients with SLE who present with multiple nodular or ring-like lesions on brain MRI, a brain biopsy with histological diagnosis is crucial for the exclusion of CNS–LYG.
Pediatric cranial stereotactic radiosurgery: Meta-analysis and international stereotactic radiosurgery society practice guidelines
Authors: Murphy Erin S , Sahgal Arjun , Regis Jean , Levivier Marc , Fariselli Laura , Gorgulho Alessandra , Ma Lijun , Pollock Bruce , Yomo Shoji , Sheehan Jason , Paddick Ian , Suh John H , Saxena Anshul , Ahmed Md Ashfaq , Kotecha Rupesh 
Published: October 2024

Abstract

Background
There are limited data on the use of stereotactic radiosurgery (SRS) for pediatric patients. The aim of this systematic review was to summarize indications and outcomes specific to pediatric cranial SRS to inform consensus guidelines on behalf of the International Stereotactic Radiosurgery Society.

Methods
A systematic review, using the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses, analyzed English-language articles on SRS, published between 1989 and 2021, that included outcomes for at least 5 pediatric patients. MEDLINE database terms included tumor types and locations, and radiosurgical and age-specific terms. We excluded nonclinical reports, expert opinions, commentaries, and review articles. Meta-regressions for associations with local control were performed for medulloblastoma, craniopharyngioma, ependymoma, glioma, and arteriovenous malformation (AVM).

Results
Of the 113 articles identified for review, 68 met the inclusion criteria. These articles described approximately 400 pediatric patients with benign and malignant brain tumors and 5119 with AVMs who underwent cranial SRS. The rates of local control for benign tumors, malignant tumors, and AVMs were 89% (95% CI, 82%–95%), 71% (95% CI, 59%–82%), and 65% (95% CI, 60%–69%), respectively. No significant associations were identified for local control with the patient-, tumor-, or treatment-related variables.

Conclusions
This review is the first to summarize outcomes specific to SRS for pediatric brain tumors and AVMs. Although data reporting is limited for pediatric patients, SRS appears to provide acceptable rates of local control. We present ISRS consensus guidelines to inform the judicious use of cranial SRS for pediatric patients.
Prevalence, treatment patterns, and survival of patients with brain metastases from small cell lung cancer: A retrospective study using the TriNetX Oncology Database
Authors: Parker Megan , Kalluri Anita , Jiang Kelly , Materi Joshua , Azad Tej D , Murray Joseph , Ha Jinny Suk , Kamson David O , Kleinberg Lawrence R , Redmond Kristin J , Brahmer Julie R , Ye Xiaobu , Bettegowda Chetan , Rincon-Torroella Jordina 
Published: October 2024

Abstract

Background
Brain metastases (BM) portend increased morbidity and mortality in patients with small cell lung cancer (SCLC). We aimed to characterize the prevalence, timing, treatment patterns, and survival outcomes of BM associated with SCLC over the past decade.

Methods
Data from 4014 patients with histologically confirmed SCLC were extracted from the TriNetX Oncology database. Clinical and demographic variables were compared between patients with and without BM using Chi-squared and t-tests. Kaplan–Meier and Cox regression analyses were used to evaluate overall survival (OS), after propensity score matching cohorts for age at diagnosis, sex, cancer stage at diagnosis, extracranial metastases, and cancer-directed therapy.

Results
Among 4014 patients with SCLC, 35.0% had BM (9.9% synchronous, 21.2% metachronous, 3.9% precocious). Patients who developed BM were younger (P &lt; .001) at SCLC diagnosis, more likely Black/African American (P = .0068), and presented with more advanced cancer stages (P &lt; .001) than patients who did not develop BM. The median BM-free survival from the time of SCLC diagnosis was 27.9 months. Patients with BM received higher rates of cancer-directed therapies than those without BM. Synchronous BM was associated with lower OS than metachronous BM after the diagnosis of SCLC (HR[95% CI] = 1.56[1.32–1.83]), but there was no difference in OS after the BM diagnosis. OS did not differ between patients with BM and patients with extracranial metastases only, following the diagnosis of metastatic disease.

Conclusions
Our findings support that independently of the chronicity of BM diagnosis, patients with SCLC have poor survival once the diagnosis of BM is conferred.
Microbiology of Actinomyces Species Isolated From Patients With Invasive Disease and Contaminated Samples in a Comprehensive Cancer Center
Authors: El-Atoum Mohammad , Gailor Mary E , Segal Brahm H , Bonnewell John P , Almyroudis Nikolaos G 
Published: October 2024

Abstract

Background
Actinomyces are mucous membrane commensals that infrequently cause invasive disease. Our goal was to define Actinomyces species prevalence, the predominant disease site and risk factors for actinomycosis.

Methods
We retrospectively reviewed patients with growth of Actinomyces species from cultures in a single-cancer center from July 2007 to June 2020. Proven invasive actinomycosis was defined as the presence of compatible clinical syndrome and radiographic findings with histopathological confirmation or culture from a normally sterile site. Probable invasive actinomycosis was defined based on the same criteria but without histologic confirmation. Contaminants were defined as culture growth in the absence of clinical or radiological findings consistent with disease. Speciation of Actinomyces was performed by the bioMerieux VITEK 2 anaerobic and coryneform identification card.

Results
Of 235 patients, 179 (76.2%) had malignancy. Among 90 (38.3%) patients with invasive actinomycosis, A odontolyticus was isolated in 32 (35.6%), followed by A meyeri in 20 (22.2%), and A naeslundii in 17 (18.9%). Among 145 (61.7%) colonized patients, A odontolyticus was isolated in 67 (46.2%), followed by A naeslundii in 27 (18.6%). Abdominopelvic infection was the most common site for invasive actinomycosis documented in 54 patients (60.0%) followed by orocervicofacial in 14 (15.6%) and thoracic in 10 (11.1%).

Conclusions
A odontolyticus, A meyeri, and A naeslundi were the most frequently isolated species causing invasive actinomycosis, and A odontolyticus and A nauslendii among colonizers. Abdominopelvic represented the most frequent site for invasive disease. Further studies are needed to investigate the epidemiology of Actinomyces species in this population.
De-etiolation is Almost Color Blind: The Study of Photosynthesis Awakening under Blue and Red Light
Authors: Banaś Agnieszka K , Leja Katarzyna , Zgłobicki Piotr , Jedynak Paweł , Kowalska Ewa , Strzałka Wojciech , Grzyb Joanna , Myśliwa-Kurdziel Beata 
Published: October 2024

Abstract
The synthesis and assembly of functioning photosynthetic complexes in chloroplasts developing from etioplasts during the de-etiolation of angiosperm seedlings are imperative for the plant’s autotrophic lifestyle. This study compared the de-etiolation process under monochromatic red or blue light of equal photon flux density during a 24-h illumination period of etiolated Arabidopsis seedlings. The aim was to elucidate the impact of these light wavelengths on the etioplast-to-chloroplast transformation and the initiation of light-dependent photosynthetic reactions. Both treatments led to the formation of functional young chloroplasts; however, the etioplast-to-chloroplast transition and the assembly of photosynthetic complexes occurred unevenly, with individual steps tuned by red or blue light. Ultrastructural analysis suggested faster prolamellar body’s disassembly under blue light, while low-temperature fluorescence studies indicated a slower transformation of protochlorophyllide to chlorophyllide, and chlorophyll a, under these conditions. The red light further promoted the synthesis of chlorophyll b and LHCII antenna proteins. However, the efficiency of antennae in dissipating excess absorbed energy was higher for seedlings de-etiolated under blue light; the maximum quantum yield of the photosystem II reached 0.81 after 24-h de-etiolation, equivalent to mature plants. Blue light seemed to enhance the development of well-functioning photosystems (I and II) and antennae. These findings are important for gaining a deeper understanding of photoreceptor regulation of de-etiolation and for utilizing selected light regimes to improve crop yield.
Engineering a cleaved, prefusion-stabilized influenza B virus hemagglutinin by identification and locking of all six pH switches
Authors: Juraszek Jarek , Milder Fin J , Yu Xiaodi , Blokland Sven , van Overveld Daan , Abeywickrema Pravien , Tamara Sem , Sharma Sujata , Rutten Lucy , Bakkers Mark J G , Langedijk Johannes P M 
Published: October 2024

Abstract
Vaccine components based on viral fusion proteins require high stability of the native prefusion conformation for optimal potency and manufacturability. In the case of influenza B virus hemagglutinin (HA), the stem's conformation relies on efficient cleavage. In this study, we identified six pH-sensitive regions distributed across the entire ectodomain where protonated histidines assume either a repulsive or an attractive role. Substitutions in these areas enhanced the protein's expression, quality, and stability in its prefusion trimeric state. Importantly, this stabilization enabled the production of a cleavable HA0, which is further processed into HA1 and HA2 by furin during exocytic pathway passage, thereby facilitating correct folding, increased stability, and screening for additional stabilizing substitutions in the core of the metastable fusion domain. Cryo-EM analysis at neutral and low pH revealed a previously unnoticed pH switch involving the C-terminal residues of the natively cleaved HA1. This switch keeps the fusion peptide in a clamped state at neutral pH, averting premature conformational shift. Our findings shed light on new strategies for possible improvements of recombinant or genetic-based influenza B vaccines.
Learning Curve Analysis for Robotic-assisted Harvest of Deep Inferior Epigastric Perforator Flap
Authors: Moreira Andrea , Chen Brian , Bailey Elizabeth , Nelson William , Murariu Daniel 
Published: October 2024

Summary:
The deep inferior epigastric perforator (DIEP) flap is the preferred method for autologous breast reconstruction after mastectomy, but risks the development of hernia, bulge, and decreased core strength. Robotic harvest of DIEP vessels may limit abdominal wall morbidity through smaller fascial incisions and preservation of motor nerves. This study shows the expected learning curve (LC) for robotic harvest and compares the LC between a general surgeon (GS) and a plastic surgeon (PS). A retrospective cohort study was performed for patients who underwent bilateral robotic DIEP flap harvest from October 2021 to September 2022. We evaluated robotic pedicle dissection time (DT) and compared the times between GS and PS. We calculated LC for each surgeon using the cumulative sum (CUSUM) method,

. The LC was identified as the peak of the CUSUM graph. Forty-four flap dissections were recorded during the collection period: 27 by the PS and 17 by the GS. There was no significant difference in DT between the GS and the PS (P = 0.366), and both surgeons saw a decrease in DT over time. Using the CUSUM method, we see the peak of the plot at patient 9 for the PS and the peak of the plot at patient 5 for the GS, after which cumulative DT decreased. As robotic harvest of DIEP flaps becomes accepted, plastic surgeons who wish to incorporate it into their practice may achieve proficiency in their DT within 10 flap harvests and a similar DT compared with robotic-trained GSs.