bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concomitant implantation of Impella® on top of veno‐arterial extracorporeal membrane oxygenation may improve survival of patients with cardiogenic shock
Authors: Pappalardo Federico , Schulte Christian , Pieri Marina , Schrage Benedikt , Contri Rachele , Soeffker Gerold , Greco Teresa , Lembo Rosalba , Müllerleile Kai , Colombo Antonio , Sydow Karsten , De Bonis Michele , Wagner Florian , Reichenspurner Hermann , Blankenberg Stefan , Zangrillo Alberto , Westermann Dirk 
Published: October 2016

AbstractAimsVeno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) support stabilizes patients with cardiogenic shock. Despite improved oxygenation and peripheral circulation, LV unloading may be impeded due to the increased afterload, resulting in a failing static left ventricle and in high mortality.Methods and resultsWe describe for the first time a large series of patients treated with the combination of VA‐ECMO and Impella® compared with patients with VA‐ECMO only. We retrospectively collected data on patients from two tertiary critical care referral centres. We enrolled 157 patients treated with VA‐ECMO from January 2013 to April 2015: 123 received VA‐ECMO support and 34 had concomitant treatment with VA‐ECMO and Impella. A propensity‐matching analysis was performed in a 2:1 ratio, resulting in 42 patients undergoing VA‐ECMO alone (control group) compared with 21 patients treated with VA‐ECMO and Impella. Patients in the VA‐ECMO and Impella group had a significantly lower hospital mortality (47% vs. 80%, P < 0.001) and a higher rate of successful bridging to either recovery or further therapy (68% vs. 28%, P < 0.001) compared with VA‐ECMO patients. A higher need for continuous veno‐venous haemofiltration (48% vs. 19%, P = 0.02) and increased haemolysis (76% vs. 33%, P = 0.004) were reported in the study group due to higher survival. There was no difference in major bleeding rates between the two groups (VA‐ECMO and Impella 38% vs. VA‐ECMO 29%, P = 0.6).ConclusionsConcomitant treatment with VA‐ECMO and Impella may improve outcome in patients with cardiogenic shock compared with VA‐ECMO only. Nevertheless, randomized studies are needed to validate these promising results further.
Rhodium and Iridium Fluorido and Bifluorido Complexes Derived from Peroxido Precursors
Authors: Baumgarth Hanna , Meier Gregor , Braun Thomas , Braun‐Cula Beatrice 
Published: October 2016

AbstractInvited for the cover of this issue is the group of Thomas Braun at Humboldt‐Universität zu Berlin, Germany. The cover image shows the reaction pathways to the bifluorido and difluorido complexes mentioned in the paper.
Comparing single-feeding and multi-feeding approaches for experimentally assessing trophic transfer of metals in fish
Authors: Pouil Simon , Warnau Michel , Oberhänsli François , Teyssié Jean-Louis , Bustamante Paco , Metian Marc 
Published: October 2016

Abstract

Diet is an important pathway for metal uptake in marine organisms, and assimilation efficiency is one of the most relevant parameters to quantify trophic transfer of metals along aquatic food webs. The most commonly used method to estimate this parameter is pulse-chase feeding using radiolabeled food. This approach is, however, based on several assumptions that are not always tested in an experimental context. The present study aimed to validate the approach by assessing single-feeding and multiple-feeding approaches, using a model species (the turbot Scophthalmus maximus). Using the kinetic data obtained from the single-feeding experiment, the reconstruction of a multi-feeding experiment was tested for consistency with data provided by an actual multi-feeding performed under the same experimental conditions. The results validated the single-feeding approach. Environ Toxicol Chem 2017;36:1227–1234. © 2016 SETAC
The construction of the Obervermuntwerk II pumped storage power station / Die Bauausführung des Pumpspeicherkraftwerks Obervermuntwerk II
Authors: Schönlechner Christian , Bitschnau Markus 
Published: October 2016

AbstractThe joint venture Bau Obervermuntwerk II, consisting of the companies Jäger Bau, Porr, Östu‐Stettin and Hinteregger are constructing the pumped storage works Obervermunt II (OVW II) under a contract from the Vorarlberger Illwerke AG between the Silvretta and the Vermunt reservoirs. The Obervermuntwerk II is being built as a parallel works to the existing Obervermuntwerk (OVW). Together with the OVW II, a new headrace is being built for the existing Obervermuntwerk and the existing overground penstock will be demolished. All excavation is being undertaken conventionally by drill and blast; only the surge tank and the pressure shaft will be excavated by raise boring previously excavated mucking shafts. The aggregates for the concrete of the Obervermunt II power station (about 200,000 m3) are being prepared from excavated material as far as possible. A dedicated material processing plant for the project is being operated in Vermunt as well as a batching plant.Die Arbeitsgemeinschaft Bau Obervermuntwerk II, bestehend aus den Firmen Jäger Bau, Porr, Östu‐Stettin und Hinteregger errichtet im Auftrag der Vorarlberger Illwerke AG zwischen dem Speichersee Silvretta und dem Speichersee Vermunt das Pumpspeicherwerk Obervermunt II (OVW II). Das Obervermuntwerk II wird als Parallelwerk zum bestehenden Obervermuntwerk (OVW) errichtet. Mit der Errichtung des OVW II wird auch eine neue Triebwasserführung für das bestehende Obervermuntwerk hergestellt und die bestehende oberirdische Druckrohrleitung abgetragen. Sämtliche Ausbrucharbeiten erfolgen konventionell im Sprengvortrieb, lediglich beim Wasserschloss und dem Druckschacht werden mittels Raiseboring vorab Schutterschächte hergestellt. Die Zuschlagstoffe für den Beton des Kraftwerks Obervermunt II (ca. 200.000 m3) werden so weit wie möglich aus dem Ausbruchmaterial aufbereitet. Für diese Maßnahme wird im Bereich Vermunt eine eigene Materialaufbereitungsanlage sowie eine Betonmischanlage betrieben.
Hydroshield drive with a diameter of 13 m in the Lower Inn Valley – Project design and experience from construction of contract H3‐4 / Hydroschildvortrieb mit 13 m Durchmesser im Unterinntal – Projektplanung und Erfahrungen im Baulos H3‐4
Authors: Klitzen Jens , Herdina Johann 
Published: October 2016

AbstractIn the Lower Inn Valley of the Tyrol, Autria, the existing railway line has been upgraded. In the course of these works a two‐track tunnel with an excavated diameter of 13.03 m was built in the track section H3‐4 Münster/Wiesing. The tunnel was excavated with a slurry TBM. Demanding geotechnical conditions on this difficult contract necessitated changes to the overall concept. After tendering and the award of contract, the client and the contractor started the construction phase with different expectations. We report on the strongly differing experiences of the parties during the construction of the works. At the end, we draw conclusions for both parties from the experience gained during the successful completion of the project.Im Tiroler Unterinntal wurde im Zuge des Ausbaus der bestehenden Bahntrasse im Streckenabschnitt H3‐4 Münster/Wiesing ein zweigleisiger Tunnel mit einem Ausbruchsdurchmesser von 13,03 m ausgeführt. Zum Einsatz kam hierbei eine Schildmaschine mit flüssigkeitsgestützter Ortsbrust. Die besonderen Anforderungen im geotechnisch anspruchsvollen Baulos haben bereits in der Phase der Projektierung eine Reihe von Anpassungen des Gesamtkonzepts erforderlich gemacht. Nach Ausschreibung und Vergabe sind Auftraggeber (AG) und Auftragnehmer (AN) mit bestimmten tlw. nicht deckungsgleichen Erwartungshaltungen in die Bauausführung gestartet. Über dies und die tlw. davon stark abweichenden Erfahrungen, die während der Ausführung gemacht wurden, wird berichtet. Zudem werden die für beide Vertragspartner wesentlichen Schlussfolgerungen aus dem technisch und vertraglich erfolgreich abgewickelten Bauvorhaben zusammengefasst.
The Granitztal Tunnel Chain – State of works on the second longest tunnel system on the Koralmbahn / Tunnelkette Granitztal – Stand der Arbeiten für das zweitlängste Tunnelsystem an der Koralmbahn
Authors: Bauer Johann , Kohlböck Bernhard , Moritz Bernd , Zwittnig Gerald 
Published: October 2016

AbstractThe Granitztal Tunnel Chain is not only the second longest tunnel system on the Koralmbahn line but also an essential part of the future new railway line between Graz and Klagenfurt (New South Range Line). At the time of reporting, more than two‐thirds of the tunnel excavation works on the Graniztal contract are completed. After a detailed description of the project with four simultaneously advancing TBM drive and the extensive concreting ad earthworks in the Granitztal, the geological and geotechnical conditions and the experience gained until now are described. Particular attention is paid to the challenging geotechnical conditions in the Langer Berg section and the overground section in the Granitztal. The intensive design work to optimise future maintenance work is also described.Mit der Tunnelkette Granitztal entsteht derzeit nicht nur das zweitlängste Tunnelsystem an der Koralmbahn, sondern ein wesentlicher Mosaikstein für die künftige Hochleistungsstrecke zwischen Graz und Klagenfurt. Zum Berichtszeitpunkt wird mehr als zwei Drittel der Vortriebsarbeiten für dieses Baulos abgeschlossen sein. Nach einer detaillierten Beschreibung des Projekts mit seinen vier gleichzeitig laufenden Vortrieben und den umfangreichen Beton‐ und Erdarbeiten im Granitztal wird über die geologischen und geotechnischen Verhältnisse und die bis dato gewonnenen Erkenntnisse berichtet. Besonderes Augenmerk wird auf die anspruchsvollen geotechnischen Verhältnisse im Abschnitt Langer Berg sowie im Übertage‐Abschnitt Granitztal gelegt. Weiters wird über die intensiven Planungsaktivitäten zum Zwecke der Instandhaltungsoptimierung berichtet.
Tunnel geothermics – International experience with renewable energy concepts in tunnelling / Tunnelgeothermie – Internationale Erfahrungen zu regenerativen Energiekonzepten im Tunnelbau
Authors: Moormann Christian , Buhmann Patrik , Friedemann Wolf , Homuth Sebastian , Pralle Norbert 
Published: October 2016

AbstractShallow geothermal energy now provides an essential contribution to the base load of heating energy. The thermal activation of tunnels is an interesting alternative and an economically appropriate supplement to the present hybrid systems in the field of ground engineering. An essential difference between the tunnel absorber and structures such as activated piles and diaphragm wall elements is the use of heat fluxes from the ground, as well as from the inside of the tunnel. Due to this circumstance, the tunnel absorber is assigned to the group of the duo‐hybrid systems. The tunnel air temperature is essential for the heat flux inside the tunnel. Stuttgart‐Fasanenhof and Jenbach are two geothermal tunnel plants which have been delivering dependable measurement data of the subsoil temperature, the tunnel lining temperature and the tunnel air temperature for four years. Based on the selected operation modes and case studies, the measurement results are analyzed and discussed. In addition, the possible geothermal potential of a geothermal tunnel system is introduced.Oberflächennahe Geothermie leistet mittlerweile einen wesentlichen Beitrag zur Grundlastversorgung mit Wärmeenergie. Die thermische Aktivierung von Tunneln ist eine interessante Alternative und ökonomisch sinnvolle Ergänzung der bisherigen Hybridsysteme des Spezialtiefbaus. Ein wesentliches Unterscheidungsmerkmal des Tunnelabsorbers gegenüber z. B. aktivierten Pfählen oder Schlitzwandelementen ist die Nutzung von Wärmeströmen sowohl aus dem Erdreich als auch aus der Tunnelluft. Damit ist der Tunnelabsorber in die Gruppe der Duo‐Hybrid‐Systeme einzuordnen. Wesentlich für den Wärmestrom aus dem Tunnelinneren ist die Tunnellufttemperatur. Mit den Tunneln Stuttgart‐Fasanenhof und Jenbach existieren zwei Tunnelgeothermieanlagen, die seit nunmehr vier Jahren verlässliche Messdaten zu Baugrund‐, Tunnelschalen‐ und Tunnellufttemperatur liefern. An ausgesuchten Betriebsphasen und Modellstudien werden Messergebnisse analysiert und diskutiert sowie das mögliche tunnelgeothermische Potenzial vorgestellt.
Active place avoidance is no more stressful than unreinforced exploration of a familiar environment
Authors: Lesburguères Edith , Sparks Fraser T. , O'Reilly Kally C. , Fenton André A. 
Published: October 2016

ABSTRACTTraining in the active place avoidance task changes hippocampus synaptic function, the dynamics of hippocampus local field potentials, place cell discharge, and active place avoidance memory is maintained by persistent PKMζ activity. The extent to which these changes reflect memory processes and/or stress responses is unknown. We designed a study to assess stress within the active place avoidance task by measuring serum corticosterone (CORT) at different stages of training. CORT levels did not differ between trained mice that learned to avoid the location of the mild foot shock, and untrained no‐shock controls exposed to the same environment for the same amount of time. Yoked mice, that received unavoidable shocks in the same time sequence as the trained mice, had significantly higher CORT levels than mice in the trained and no‐shock groups after the first trial. This increase in CORT disappeared by the fourth trial the following day, and levels of CORT for all groups matched that of home cage controls. The data demonstrate that place avoidance training is no more stressful than experiencing a familiar environment. We conclude that changes in neural function as a result of active place avoidance training are likely to reflect learning and memory processes rather than stress. © 2016 Wiley Periodicals, Inc.
Hypermethylation of PRDM1/Blimp‐1 promoter in extranodal NK/T‐cell lymphoma, nasal type: an evidence of predominant role in its downregulation
Authors: Zhang Zhang , Liang Li , Li Dong , Nong Lin , Liu Jumei , Qu Linlin , Zheng Yalin , Zhang Bo , Li Ting 
Published: October 2016

AbstractThe loss of PRDM1 expression is common in extranodal NK/T‐cell lymphoma, nasal type (EN‐NK/T‐NT), but the role of promoter methylation in silencing PRDM1 expression remains unclear. Hence, we performed pyrosequencing analysis to evaluate the promoter methylation of PRDM1 gene in vivo and in vitro, to analyze the association between methylation and its expression, and to assess cellular effects of PRDM1 reexpression. The promoter hypermethylation of PRDM1 gene was detected in 11 of 25 EN‐NK/T‐NT cases (44.0%) and NK92 and NKL cells. The promoter hypermethylation of PRDM1 was significantly correlated with PRDM1 expression in vivo and in vitro, predominantly contributing to the loss of PRDM1 expression compared with genetic deletion and aberrant expression of miR‐223 in EN‐NK/T‐NT. PRDM1 expression was significantly restored by demethylation treatment, which induced cell proliferation suppression, cell cycle arrest, and apoptosis increase. We also found that PRDM1 reexpression could downregulate the expression of Ets‐1, T‐bet, granzyme B, and c‐myc. Our findings demonstrated that the promoter hypermethylation of PRDM1 harbored a predominant role in the downregulation of PRDM1 expression, significantly affecting the biological behavior of tumor cells in EN‐NK/T‐NT.
Experimental Investigation of Overall Heat Transfer Coefficient of Al2O3/Water–Mono Ethylene Glycol Nanofluids in an Automotive Radiator
Authors: Subhedar Dattatraya G. , Ramani Bharat M. , Gupta Akhilesh 
Published: October 2016

AbstractIn this research, the overall heat transfer coefficient of Al2O3/water–mono ethylene glycol (MEG) nanofluids is investigated experimentally in a car radiator under laminar flow conditions. The experimental rig developed is similar to the automotive cooling system. The stable nanofluid used is prepared by a two‐step method. Ultrasonication is done for proper dispersion of 20 nm Al2O3 nanoparticle in carrier fluid water and MEG mixture with 50:50 proportions by volume. The experimental study showed that use of a nanofluid enhances the overall heat transfer coefficient as compared to the base fluid. In this study as the nanoparticle volume fraction increases from 0% to 0.8%, the overall heat transfer coefficient also increases. It was observed that as the nanofluid inlet temperature increased from 65 °C to 85 °C, the overall heat transfer coefficient decreased. It was found that using a 0.2% volume fraction Al2O3/water–MEG nanofluid can enable a 36.69 % reduction in surface area of the radiator.
Monitoring litter interception of rainfall using leaf wetness sensor under controlled and field conditions
Authors: Acharya Bharat Sharma , Stebler Elaine , Zou Chris B. 
Published: October 2016

AbstractLeaf litter interception of water is an integral component of the water budget for some vegetated ecosystems. However, loss of rainfall to litter receives considerably less attention than canopy interception due to lack of suitable sensors to measure changes in litter water content. In this study, a commercially available leaf wetness sensor was calibrated to the gravimetric water content of eastern redcedar (Juniperus virginiana) litter and used to estimate litter interception in a subhumid eastern redcedar woodland in north‐central Oklahoma. Under controlled laboratory conditions, a strong positive correlation between the leaf wetness sensor output voltage (mV) and measured gravimetric litter water content (ϴg) was determined: ϴg = (.0009 × mV2) − (0.14 × mV) − 11.41 (R2 = .94, p < .0001). This relationship was validated with field sampling and the output voltage (mV) accounted for 48% of the observed variance in the measured water content. The maximum and minimum interception storage capacity ranged between 1.16 and 12.04 and 1.12 and 9.62 mm, respectively. The maximum and minimum amount of intercepted rain was positively correlated to rainfall amount and intensity. The continuous field measurements demonstrated that eastern redcedar litter intercepted approximately 8% of the gross rainfall that fell between December 16, 2014 and May 31, 2015. Therefore, rainfall loss to litter can constitute a substantial component of the annual water budget. Long‐term in situ measurement of litter interception loss is necessary to gain a better estimate of water availability for streamflow and recharge. This is critical to manage water resources in the south‐central Great Plains, USA where grasslands are rapidly being transformed to woodland or woody dominated savanna.
Passivity enforced circuit model of frequency‐domain responses with source elements
Authors: Su Donglin , Li Bing , Wang Junjun , Song Xinwei 
Published: October 2016

AbstractThis paper presents an equivalent circuit model with source elements for systems containing external field. The coupling effect of the external field is considered with current sources (Is) added to the expression of admittance matrix (Y) of the system. The frequency‐domain responses of Y and Is could be fit to the rational polynomials with vector fitting method and then converted to equivalent circuits with the proposed method. As the dual quantities of Y and Is, the circuit extraction method from Z and Vs is also introduced. Passivity enforcement of the RLC elements in the circuits is realized with the optimization method. A novel circuit structure for the multi‐port system is proposed with this method based on the equivalence of the field‐port coupling and port‐port coupling. The proposed model is demonstrated to be effective to extract the equivalent circuits of the multiconductor transmission line system under an incident wave.
Effects of cell type and configuration on anabolic and catabolic activity in 3D co‐culture of mesenchymal stem cells and nucleus pulposus cells
Authors: Ouyang Ann , Cerchiari Alec E. , Tang Xinyan , Liebenberg Ellen , Alliston Tamara , Gartner Zev J. , Lotz Jeffrey C. 
Published: October 2016

ABSTRACTTissue engineering constructs to treat intervertebral disc degeneration must adapt to the hypoxic and inflammatory degenerative disc microenvironment. The objective of this study was to determine the effects of two key design factors, cell type and cell configuration, on the regenerative potential of nucleus pulposus cell (NPC) and mesenchymal stem cell (MSC) constructs. Anabolic and catabolic activity was quantified in constructs of varying cell type (NPCs, MSCs, and a 50:50 co‐culture) and varying configuration (individual cells and micropellets). Anabolic and catabolic outcomes were both dependent on cell type. Gene expression of Agg and Col2A1, glycosaminoglycan (GAG) content, and aggrecan immunohistochemistry (IHC), were significantly higher in NPC‐only and co‐culture groups than in MSC‐only groups, with NPC‐only groups exhibiting the highest anabolic gene expression levels. However, NPC‐only constructs also responded to inflammation and hypoxia with significant upregulation of catabolic genes (MMP‐1, MMP‐9, MMP‐13, and ADAMTS‐5). MSC‐only groups were unaffected by degenerative media conditions, and co‐culture with MSCs modulated catabolic induction of the NPCs. Culturing cells in a micropellet configuration dramatically reduced catabolic induction in co‐culture and NPC‐only groups. Co‐culture micropellets, which take advantage of both cell type and configuration effects, had the most immunomodulatory response, with a significant decrease in MMP‐13 and ADAMTS‐5 expression in hypoxic and inflammatory media conditions. Co‐culture micropellets were also found to self‐organize into bilaminar formations with an MSC core and NPC outer layer. Further understanding of these cell type and configuration effects can improve tissue engineering designs. © 2016 The Authors. Journal of Orthopaedic Research published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 35:61–73, 2017.