bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rate and Timing of Revision and Contralateral Anterior Cruciate Ligament Reconstruction Relative to Index Surgery
Authors: Halperin Scott J. , Dhodapkar Meera M. , McLaughlin William M. , Hewett Timothy E. , Grauer Jonathan N. , Medvecky Michael J. 
Published: October 2024

Background: After anterior cruciate ligament (ACL) reconstruction (ACLR), ipsilateral ACL graft reinjury or contralateral ACL injury has been reported. The rate and predictors of such subsequent ACL injuries have not been reported in recent years and in large patient cohorts. Purpose: The current study utilized a large, national, multi-insurance, administrative database to assess subsequent ACLR and factors associated with its occurrence. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Using the PearlDiver M151 database, patients who underwent ACLR within the United States between 2015 and 2021 were abstracted. All included patients had ≥3 years of evaluation after initial ACLR. Patients who underwent a subsequent reconstruction (ipsilateral or contralateral) within 3 years were determined and the timing assessed. Using univariable and multivariable logistic regression, the factors associated with having a subsequent ACLR and the factors associated with returning for ipsilateral versus contralateral ACLR were examined. Results: In total, 40,151 patients who underwent initial ACLR during the study period were identified. Of these, subsequent ACLR was performed for 1689 patients (4.2%). These included ipsilateral revision for 1018 (60.3%) and contralateral reconstruction for 671 (39.7%) patients. Patients returning for ipsilateral reconstruction did so sooner than patients needing a contralateral reconstruction. On multivariable analysis, the only factor independently associated with subsequent ACLR was younger age (odds ratio [OR] = 4.17 for 10-14 years relative to 25-29 years; P < .0001). Factors associated with returning for an ipsilateral revision ACLR as opposed to contralateral ACLR were earlier revision (OR = 1.49 within 1.5 years relative to after 1.5 years; P = .0001) and female sex (OR = 0.62 relative to male sex; P < .0001). Conclusion: The overall rate of requiring a subsequent ACLR was found to be 4.2%, with 60.3% of these being to the ipsilateral ACL. This information may be helpful for evolving injury-prevention programs and patient counseling.
A phase 2 multicenter trial of ruxolitinib to treat bronchiolitis obliterans syndrome after allogeneic HCT
Authors: DeFilipp Zachariah , Kim Haesook T. , Cheng Guang-Shing , Hamilton Betty K. , Chhabra Saurabh , Hamadani Mehdi , Sandhu Karamjeet S. , Perez Lia , Lee Catherine J. , Brennan Timothy L. , Garrelts Cassandra , Brown Bergin M. , Gallagher Kathleen , Newcomb Richard A. , El-Jawahri Areej , Chen Yi-Bin 
Published: October 2024

Abstract
Bronchiolitis obliterans syndrome (BOS) occurring after allogeneic hematopoietic cell transplantation (HCT) is a high-risk manifestation of chronic graft-versus-host disease. In this prospective, multicenter phase 2 trial, adult participants with BOS were treated with ruxolitinib 10 mg twice daily, continuously in 28-day cycles for up to 12 cycles. Participants enrolled into newly diagnosed (&lt;6 months since BOS diagnosis, cohort A) or established (≥6 months since BOS diagnosis, cohort B) disease cohorts. The primary objective was to evaluate the early treatment effect of ruxolitinib, assessed by the change in forced expiratory volume in 1 second (FEV1) at 3 months compared with enrollment. The primary end point differed according to cohort (cohort A, improvement, defined as ≥10% increase in FEV1; cohort B, stabilization, defined as an absence of ≥10% decrease in FEV1). Between 2019 and 2022, 49 participants meeting the criteria for BOS were enrolled and treated (cohort A, n = 36; cohort B, n = 13). The primary end point was achieved by 27.8% of participants with new BOS and 92.3% of participants with established BOS. According to the 2014 National Institutes of Health Consensus Criteria, the best lung-specific overall response rate on ruxoltinib for the 49 participants was 34.7% (16.3% complete response and 18.4% partial response), with most responses occurring in mild or moderate disease. Noninfectious severe (grade ≥3) treatment-emergent adverse events were infrequent. Nine severe infectious events occurred and were largely respiratory in nature. These results support the use of ruxolitinib in the management of BOS after allogeneic HCT. This trial was registered at www.ClinicalTrials.gov as #NCT03674047.
Estimation of mass and moisture content of flat square lumber in a stack during air-drying process by the vibration method with additional mass
Authors: Kubojima Yoshitaka , Sonoda Satomi , Kato Hideo 
Published: October 2024

AbstractA vibration test to measure the mass of a specimen without weighing it using the difference between the resonance frequency with an additional mass and that without it (vibration method with additional mass, VAM) was applied to Japanese cedar flat square lumber with dimensions of 210 mm × 135 mm × 3000 mm both with and without a pith in the process of air-drying. The longitudinal and bending vibration tests were performed on the specimens with and without an additional mass. The accuracy of VAM that was expressed by the estimated mass by VAM to the measured mass (MVAM/M0) was sufficiently high throughout the air-drying process. The accuracy of VAM for the longitudinal vibration was higher than that for the bending vibration. The moisture content based on the estimated mass by VAM was in the expected range.
Large right middle cerebral artery stroke with hemorrhagic transformation
Authors: Niles Jack , Bhasin Garv , Ganti Latha 
Published: October 2024

AbstractThe authors present a case of an acute right middle cerebral artery infarct in a 65-year-old male with a history of diabetes, hypertension, and cardiovascular disease. The timeline of treatment and the evolution of the stroke is described. This case highlights the significant burden of right-sided cerebral artery stroke, even when intervention is swift.
The power of deep learning in simplifying feature selection for hepatocellular carcinoma: a review
Authors: Mostafa Ghada , Mahmoud Hamdi , Abd El-Hafeez Tarek , E.ElAraby Mohamed 
Published: October 2024

Abstract
Background
Hepatocellular Carcinoma (HCC) is a highly aggressive, prevalent, and deadly type of liver cancer. With the advent of deep learning techniques, significant advancements have been made in simplifying and optimizing the feature selection process.

Objective
Our scoping review presents an overview of the various deep learning models and algorithms utilized to address feature selection for HCC. The paper highlights the strengths and limitations of each approach, along with their potential applications in clinical practice. Additionally, it discusses the benefits of using deep learning to identify relevant features and their impact on the accuracy and efficiency of diagnosis, prognosis, and treatment of HCC.

Design
The review encompasses a comprehensive analysis of the research conducted in the past few years, focusing on the methodologies, datasets, and evaluation metrics adopted by different studies. The paper aims to identify the key trends and advancements in the field, shedding light on the promising areas for future research and development.

Results
The findings of this review indicate that deep learning techniques have shown promising results in simplifying feature selection for HCC. By leveraging large-scale datasets and advanced neural network architectures, these methods have demonstrated improved accuracy and robustness in identifying predictive features.

Conclusions
We analyze published studies to reveal the state-of-the-art HCC prediction and showcase how deep learning can boost accuracy and decrease false positives. But we also acknowledge the challenges that remain in translating this potential into clinical reality.
A multifaceted analysis of decreasing trust in health institutions in the EU during the COVID-19 pandemic
Authors: Yaddanapudi Lahari , Hahn Julia , Ladikas Miltos 
Published: October 2024

Abstract
Background
Public trust is crucial during health crises, such as the COVID-19 pandemic, for the effective implementation of scientific and policy interventions. This study investigates factors contributing to the decline in trust in the health sector within the European Union during the pandemic.

Methods
Using the publicly available 2020–2022 Standard Eurobarometer dataset, we employed a "geography of trust" approach. We applied equal quantile mapping to visualise high and low trust countries and Local Spatial Autocorrelation (LISA) to identify statistically significant clusters. Using a series of one-way ANOVA, we found associations between socio-economic and other variables available in the same dataset with trust.

Results
Trust in health institutions and medical staff declined in 20 of 27 EU countries from 2020 to 2022. Clear geographical clusters of Western and Central Europe as the high-trust countries and Eastern Europe as the low-trust countries emerged through mapping. One-way ANOVA revealed that contrary to several studies, age, gender, and most demographics did not vary with trust, but trust was directly associated with the satisfaction with measures taken to fight the COVID-19 pandemic, and individual perceptions about their life and national affairs (p < 0.001).

Conclusion
High-trust Western European countries share characteristics in health systems, governance, and pandemic responses. Understanding this interplay could inform trust-building strategies. The persistent low trust in Eastern Europe may stem from slow government responses and requires nuanced approaches considering unique contexts. The decline in traditionally high-trust countries highlights challenges even in established social contexts. This study provides valuable insights for policymakers aiming to foster trust during health crises.
Digital communication between mothers and community health workers to support neonatal health (CHV-NEO): study protocol for a randomized controlled trial
Authors: Ronen Keshet , Pothan Lincoln C. , Apondi Violet , Otieno Felix A. , Mwakanema Daniel , Otieno Felix O. , Osborn Lusi , Dettinger Julia C. , Shrestha Priyanka , Manguerra Helena , Mukumbang Ferdinand , Masinde Millicent , Waweru Evelyn , Amulele Mercy , Were Christine , Wasunna Beatrice , John-Stewart Grace , Weiner Bryan , Means Arianna Rubin , Richardson Barbra A. , Hedstrom Anna B. , Unger Jennifer A. , Kinuthia John 
Published: October 2024

Abstract
Background
Provision of essential newborn care at home, rapid identification of illness, and care-seeking by caregivers can prevent neonatal mortality. Mobile technology can connect caregivers with information and healthcare worker advice more rapidly and frequently than healthcare visits. Community health workers (CHWs) are well-suited to deliver such interventions. We developed an interactive short message service (SMS) intervention for neonatal health in Kenya, named CHV-NEO. CHV-NEO sends automated, theory-based, actionable, messages throughout the peripartum period that guide mothers to evaluate maternal and neonatal danger signs and facilitate real-time dialogue with a CHW via SMS. We integrated this intervention into Kenya’s national electronic community health information system (eCHIS), which is currently used at scale to support CHW workflow.

Methods
The effect of CHV-NEO on clinical and implementation outcomes will be evaluated through a non-blinded cluster randomized controlled trial. Twenty sites across Kisumu County in Western Kenya were randomized 1:1 to provide either the national eCHIS with integrated CHV-NEO messaging (intervention) or standard of care using eCHIS without CHV-NEO (control). We will compare neonatal mortality between arms based on abstracted eCHIS data from 7200 pregnant women. Secondary outcomes include self-reported provision of essential newborn care (appropriate cord care, thermal care, and timely initiation of breastfeeding), knowledge of neonatal danger signs, and care-seeking for neonatal illness, compared between arms based on questionnaires with a subgroup of 2000 women attending study visits at enrollment in pregnancy and 6 weeks postpartum. We will also determine CHV-NEO’s effect on CHW workflows and evaluate determinants of intervention acceptability, adoption, and fidelity of use through questionnaires, individual interviews, and messaging data.

Discussion
We hypothesize that the CHV-NEO direct-to-client communication strategy can be successfully integrated within existing CHW workflows and infrastructure, improve the provision of at-home essential newborn care, increase timely referral of neonatal illness to facilities, and reduce neonatal mortality. The intervention’s integration into the national eCHIS tool will facilitate rapid scale-up if it is clinically effective and successfully implemented.

Trial registration
ClinicalTrials.gov, NCT05187897. The CHV-NEO study was registered on January 12, 2022.
Terminal differentiation precedes functional circuit integration in the peduncle neurons in regenerating Hydra vulgaris
Authors: Escobar Alondra , Kim Soonyoung , Primack Abby S. , Duret Guillaume , Juliano Celina E. , Robinson Jacob T. 
Published: October 2024

AbstractUnderstanding how neural circuits are regenerated following injury is a fundamental question in neuroscience. Hydra is a powerful model for studying this process because it has a simple neural circuit structure, significant and reproducible regenerative abilities, and established methods for creating transgenics with cell-type-specific expression. While Hydra is a long-standing model for regeneration and development, little is known about how neural activity and behavior is restored following significant injury. In this study, we ask if regenerating neurons terminally differentiate prior to reforming functional neural circuits, or if neural circuits regenerate first and then guide the constituent naive cells toward their terminal fate. To address this question, we developed a dual-expression transgenic Hydra line that expresses a cell-type-specific red fluorescent protein (tdTomato) in ec5 peduncle neurons, and a calcium indicator (GCaMP7s) in all neurons. With this transgenic line, we can simultaneously record neural activity and track the reappearance of the terminally-differentiated ec5 neurons. Using SCAPE (Swept Confocally Aligned Planar Excitation) microscopy, we monitored both calcium activity and expression of tdTomato-positive neurons in 3D with single-cell resolution during regeneration of Hydra’s aboral end. The synchronized neural activity associated with a regenerated neural circuit was observed approximately 4 to 8 hours after expression of tdTomato in ec5 neurons. These data suggest that regenerating ec5 neurons undergo terminal differentiation prior to re-establishing their functional role in the nervous system. The combination of dynamic imaging of neural activity and gene expression during regeneration make Hydra a powerful model system for understanding the key molecular and functional processes involved in neural regeneration following injury.
A multivariate approach to assessing landscape structure effects on wildlife crossing structure use
Authors: Yamashita Thomas J. , Perotto-Baldivieso Humberto L. , Wester David B. , Ryer Kevin W. , Kline Richard J. , Tewes Michael E. , Young John H. , Lombardi Jason V. 
Published: October 2024

Abstract
Background
Complexity in landscape structure is often assessed using individual metrics related to ecological processes. However, this rarely incorporates important relationships among metrics and may miss landscape structure effects. Multivariate statistics provide techniques for assessing overall landscape structure effects. We assessed how multivariate statistics could be used to connect landscape structure with an ecological process [bobcat (Lynx rufus) wildlife crossing structure (WCS) use]. We tested how landscape structure at WCS sites compared to the surrounding landscape and how structure affected detections at WCS sites. Our study was conducted in Cameron County, Texas, USA where WCSs are in various stages of construction and monitoring. We used a classified land use/land cover map and aerial LiDAR to calculate configuration and density metrics at WCS and random sites. We created indices for configuration and density using principal components analysis to assess landscape structure effects on camera trap detections at WCSs.

Results
Landscape structure at WCSs did not differ from random locations. Wildlife crossing structure use increased with greater woody cover and decreased with increasing vegetation density. Our indices allowed identification of differences in how configuration and density impacted WCS use. Ordination methods helped identify individual contributions of landscape metrics to the overall landscape structure effect.

Conclusions
Wildlife crossing structures are permanent fixtures on landscapes, so selecting appropriate locations using broad-scale landscape structure likely increases target species use. Using indices of landscape structure provides planners with a more holistic approach to WCS placement and provides a more comprehensive picture of landscape pattern and process relationships.
Growth of sulfate-reducing Desulfobacterota and Bacillota at periodic oxygen stress of 50% air-O2 saturation
Authors: Dyksma Stefan , Pester Michael 
Published: October 2024

Abstract
Background
Sulfate-reducing bacteria (SRB) are frequently encountered in anoxic-to-oxic transition zones, where they are transiently exposed to microoxic or even oxic conditions on a regular basis. This can be marine tidal sediments, microbial mats, and freshwater wetlands like peatlands. In the latter, a cryptic but highly active sulfur cycle supports their anaerobic activity. Here, we aimed for a better understanding of how SRB responds to periodically fluctuating redox regimes.

Results
To mimic these fluctuating redox conditions, a bioreactor was inoculated with peat soil supporting cryptic sulfur cycling and consecutively exposed to oxic (one week) and anoxic (four weeks) phases over a period of > 200 days. SRB affiliated to the genus Desulfosporosinus (Bacillota) and the families Syntrophobacteraceae, Desulfomonilaceae, Desulfocapsaceae, and Desulfovibrionaceae (Desulfobacterota) successively established growing populations (up to 2.9% relative abundance) despite weekly periods of oxygen exposures at 133 µM (50% air saturation). Adaptation mechanisms were analyzed by genome-centric metatranscriptomics. Despite a global drop in gene expression during oxic phases, the perpetuation of gene expression for energy metabolism was observed for all SRBs. The transcriptional response pattern for oxygen resistance was differentiated across individual SRBs, indicating different adaptation strategies. Most SRB transcribed differing sets of genes for oxygen consumption, reactive oxygen species detoxification, and repair of oxidized proteins as a response to the periodical redox switch from anoxic to oxic conditions. Noteworthy, a Desulfosporosinus, a Desulfovibrionaceaea, and a Desulfocapsaceaea representative maintained high transcript levels of genes encoding oxygen defense proteins even under anoxic conditions, while representing dominant SRB populations after half a year of bioreactor operation.

Conclusions
In situ-relevant peatland SRB established large populations despite periodic one-week oxygen levels that are one order of magnitude higher than known to be tolerated by pure cultures of SRB. The observed decrease in gene expression regulation may be key to withstand periodically occurring changes in redox regimes in these otherwise strictly anaerobic microorganisms. Our study provides important insights into the stress response of SRB that drives sulfur cycling at oxic-anoxic interphases.
Intraoperative indocyanine green fluorescence for precise resection of nonocclusive mesenteric ischemia: a case report and diagnostic considerations based on pathology findings
Authors: Mizukami Akihito , Furuya Shinji , Takiguchi Koichi , Shiraishi Kensuke , Nakata Yuki , Akaike Hidenori , Kawaguchi Yoshihiko , Amemiya Hidetake , Kawaida Hiromichi , Ichikawa Daisuke 
Published: October 2024

Abstract
Background
Nonocclusive mesenteric ischemia (NOMI) is characterized by intestinal ischemia caused by spasms in the peripheral intestinal vessels without organic obstruction in the main mesenteric vessels. NOMI can be fatal in case of delayed diagnosis and treatment. Although the use of indocyanine green (ICG) fluorescence in assessing intestinal viability during NOMI surgery is well recognized, there is a paucity of reported cases using this technique. Herein, we present a case of NOMI that was successfully managed through accurate diagnosis and resection of the ischemic intestines guided by ICG fluorescence.

Case presentation
An 81-year-old man presented with abdominal pain. Contrast-enhanced computed tomography revealed intrahepatic portal vein gas, superior mesenteric vein gas, and terminal ileal edema. Considering these findings, the patient was diagnosed with NOMI and emergency surgery was performed. Intestinal edema was observed 30 cm upstream of the terminal ileum without serosal discoloration. ICG fluorescence revealed areas of normal perfusion as well as mild and moderate hypoperfusion. The small bowel, including the hypoperfusion area, was resected. As no clinical signs of residual bowel ischemia were observed during the postoperative course, a second-look operation was deemed unnecessary. Intraoperative ICG fluorescence and histopathological findings indicated mucosal edema in the mildly hypoperfused area and mucosal necrosis in the moderately hypoperfused area.

Conclusions
This case highlights the use of intraoperative ICG fluorescence in the disease. ICG fluorescence is invaluable in assessing the extent of bowel ischemia and guiding precise resection. Thus, future efforts should focus on identifying accumulation of cases and quantification of ICG fluorescence intensity to further improve diagnostic performance.
High-grade mucinous tubular and spindle cell carcinoma of the kidney in a patient on hemodialysis: a case report and literature review
Authors: Yamashita Kaori , Yoshida Keita , Sakamoto Tetsushi , Kubota Satoshi , Shiseki Takahiro , Nakazawa Tadao , Nagashima Yoji , Inui Masashi 
Published: October 2024

Abstract
Background
End-stage renal disease is a risk factor for renal cell carcinoma. However, mucinous tubular and spindle cell carcinoma of the kidney is rare. We report a patient on hemodialysis who had high-grade mucinous tubular and spindle cell carcinoma of the kidney.

Case presentation
A 62-year-old Japanese woman had end-stage renal disease and had been on hemodialysis for the previous 4 years. However, periodic imaging examinations to detect kidney cancer had not been conducted. The patient visited our department of urology complaining of general fatigue and dyspnea. Computed tomography with enhancement revealed a solid renal mass with a diameter of 66 mm. It had invaded the right psoas muscle and had multiple lymph node metastases. In addition, the patient had massive ascites and right-sided predominant pleural effusion. We drained the pleural effusion, but she died 11 days after admission. An autopsy was performed. Pathological examination revealed high-grade mucinous tubular and spindle cell carcinoma of the right kidney; multiple organ metastases to the bilateral lungs, liver, gall bladder, uterus, ovary, and inferior vena cava; cancerous pleuritis; and cancerous peritonitis. Our case indicates that high-grade mucinous tubular and spindle cell carcinoma emerging in end-stage kidney causes a detrimental clinical course.

Conclusion
High-grade mucinous tubular and spindle cell carcinoma of the kidney had a severe clinical course. We recommend periodic screening of patients with end-stage renal disease, using computed tomography or ultrasound.