bluuebunny/crossref_metadata_2025_split huggingface dataset:
РОЗВИТОК ДІТЕЙ, НАРОДЖЕНИХ ІЗ ЗАСТОСУВАННЯМ ДОПОМІЖНИХ РЕПРОДУКТИВНИХ ТЕХНОЛОГІЙ: ПСИХОСОЦІАЛЬНІ АСПЕКТИ У ПЕРІОДІ ВАГІТНОСТІ ТА ОСОБЛИВОСТІ СТАНУ ЗДОРОВ’Я НА ПЕРШОМУ РОЦІ ЖИТТЯ
Authors: Synenko V. V. 
Published: March 2016

<p>Резюме. У роботі проведено аналіз захворюваності, динаміки психофізичного розвитку 28 дітей, народжених із застосуванням ДРТ, на першому році життя. Встановлено, що такі діти мають певні закономірності росту і розвитку, а також широкий спектр діагностованої патології. Паралельно проведено порівняльне обстеження вагітних жінок, які попередньо спостерігалися з приводу безпліддя, задля виявлення особливостей різних сфер життєдіяльності. Отримані дані дозволили зробити висновок щодо необхідності оптимізації спостереження дітей та жінок означених категорій.</p><p> </p>Ключові слова: діти, допоміжні репродуктивні технології, психофізичний стан.
ДОСЛІДЖЕННЯ ЯКІСНИХ ОСОБЛИВОСТЕЙ ФАРМАЦЕВТИЧНОГО ЗАБЕЗПЕЧЕННЯ ХВОРИХ НА ЦИРОЗИ ПЕЧІНКИ ІЗ ВСТАНОВЛЕНИМИ УСКЛАДНЕННЯМИ ОСНОВНОГО ДІАГНОЗУ
Authors: Fedyak I. O. , Maksymenko О. V. , Sholoyko N. V. 
Published: March 2016

<p>РЕЗЮМЕ. У статті наведено результати частотного аналізу листків призначень хворих на цирози печінки різної етіології. Вони вказують, що препарати, які були спожиті пацієнтами в умовах стаціонару, насамперед призначалися для лікування ускладнень основного діагнозу. Встановлено, що гепатоцелюлярна недостатність різного ступеня спостерігалася у 94 % пацієнтів, портальна гіпертензія – у 87,4 %, асцит – у 37,9 %. Тому найчастіше призначали: Верошпірон (Gedeon Richter Plc., Угорщина) – отримали 64,2 % пацієнтів, Тіогама Турбо (Woerwag Pharma GmbH &amp; Co. KG, Німеччина) – 45,8 % та Дуфалак (Solvay Pharmaceuticals B.V., Нідерланди) – 41 % хворих.</p><p> </p><p>КЛЮЧОВІ СЛОВА: цирози печінки; ускладнення цирозу печінки; частотний аналіз; лікарські засоби, що застосовуються при захворюваннях печінки.</p>
Emergency Cardiovascular Hospitalization Risk Attributable to Cold Temperatures in Hong Kong
Authors: Tian Linwei , Qiu Hong , Sun Shengzhi , Lin Hualiang 
Published: March 2016

Background—
Associations between ambient temperature and cardiovascular morbidity have been well studied worldwide; however, few studies determined the cardiovascular disease burden attributable to temperature. We aimed to assess the risk attributed to temperature based on the exposure–lag–response relationship between temperature and circulatory diseases.

Methods and Results—
We collected daily time series data of emergency hospital admissions, mean temperature, and air pollution concentrations from January 2005 to December 2012 in Hong Kong. The association with temperature was modeled using a distributed lag nonlinear model integrated in quasi-Poisson regression. The cumulated effects of cold/hot temperature were abstracted. Attributable risk measures because of below optimal temperature (OT) were calculated to summarize the disease burden, and further separated into contributions from moderate and extreme cold temperatures. We observed significant nonlinear and delayed cold effect but no apparent hot effect lasting for 3 weeks on emergency circulatory hospitalizations. Compared with the identified OT at 23.0°C, the cumulative relative risk during 0 to 21 lag days was 1.69 (95% confidence interval, 1.56–1.82) for extreme cold (first percentile) and 1.22 (95% confidence interval, 1.15–1.29) for moderate cold temperature (10th percentile). Cold temperatures were responsible for temperature-related circulatory emergency hospitalizations, with attributable fraction of 6.33% for moderate cold and 0.82% for extreme cold while inducing 33 030 and 4257 cases, respectively. Several specific causes of cardiovascular diseases showed higher vulnerability.

Conclusions—
Moderate cold weather was responsible for a considerable attributable risk for cardiovascular diseases. The temperature-related hospitalizations risk found in this study may provide evidence for guiding the public health policies and preventions for cardiovascular diseases.
Stroke, Physical Function, and Death Over a 15-Year Period in Older Australian Women
Authors: Hubbard Isobel J. , Vo Kha , Forder Peta M. , Byles Julie E. 
Published: March 2016

Background and Purpose—
As populations age, an increasing number of older women are living with stroke. This study looks at long-term outcomes for women with stroke, comparing mortality rates for women with poor physical function (PF) and those with higher levels of function. The purpose is to understand not only how long women might live after a stroke, but also how long they live with physical disability.

Methods—
The study uses 15 years of data on women from the Australian Longitudinal Study on Women’s Health 1921 to 1926 cohort. The risk of stroke and the risk of stroke and poor PF were estimated using Cox proportional hazard model. Among women who reported a stroke during the study period, mortality risk was compared according to their physical functioning level after that stroke.

Results—

Almost half of the women who had a stroke and poor PF survived past 10 years. The 10-year mortality rate was 37% for women with stroke and adequate PF and 51% for women with stroke and poor PF at the time of the stroke (hazard rate ratio, 1.52; 95% CI, 1.18–1.95;
P
=0.0015 adjusting for demographic and health covariates).

Conclusions—
This study provides evidence of the long-term outcomes of stroke among older women, with women living for many years with poor PF. This outcome has important implications for the women’s quality of life during their later years and in understanding the burden of disability associated with stroke.
Acute Rhinosinusitis
Authors: Benninger Michael S. , Holy Chantal E. , Trask Douglas K. 
Published: March 2016

ObjectiveUnderstand real‐world prescription patterns for patients presenting with a first diagnosis of ARS and evaluate adherence to published medical guidelines.Study DesignRetrospective administrative database analysis.SettingUS‐based outpatient settings.MethodsFrom a US claims database (MarketScan), 99,033 patients were identified with acute rhinosinusitis (ARS) in 2012 (“index”), with a complete medical and prescription history for 12 months preindex and 18 months postindex and no diagnoses of asthma or chronic rhinosinusitis. Of these, a random 10,000‐patient sample was generated matched for age and sex to the initial cohort. Prescriptions and procedures at index, as well as complications up to 12 months postindex, were analyzed.ResultsNearly 90% of all patients received a prescription at index. Antibiotics were prescribed for 84.8% patients, followed by antitussives (16.2% for adults, 6.2% for pediatrics), nasal corticosteroids (15.5% adults, 7.5% for pediatrics), and systemic corticosteroids (10.3% for adults, 5.5% for pediatrics), with 49% adults and 29% children receiving >1 medication at first visit. Macrolides were the most frequently prescribed antibiotics (35.6% adults, 28.6% pediatrics), followed by amoxicillin/clavulanate and amoxicillin. Within 12 months of index, 3 patients presented with meningitis and 3 with orbital cellulitis.ConclusionSignificant variability in ARS treatment was observed, highlighting the need for heightened awareness of existing guidelines.
Quantitative Proteomics of Vestibular Schwannoma Cerebrospinal Fluid
Authors: Kazemizadeh Gol Mohammad Abraham , Lund Troy C. , Levine Samuel C. , Adams Meredith E. 
Published: March 2016

This pilot study aimed to identify candidate proteins for future study that are differentially expressed in vestibular schwannoma (VS) cerebrospinal fluid (CSF) and to compare such proteins with those previously identified in perilymph and specimen secretions. CSF was collected intraoperatively prior to removal of untreated sporadic VS (3 translabyrinthine, 3 middle cranial fossa approaches) and compared with reference CSF samples. After proteolytic digestion and iTRAQ labeling, tandem mass spectrometry with ProteinPilot was used to identify candidate proteins. Of the 237 proteins detected, 13 were dysregulated in ≥3 of the 6 VS patients versus controls, and 13 were dysregulated (12 up, 1 down) in samples from patients with class D versus class B hearing. Four perilymph proteins of interest were dysregulated in ≥1 VS CSF samples. Thus, 26 candidate VS CSF biomarkers were identified that should be considered in future VS biomarker and tumor pathophysiology investigations.
A Systematic Review of Diuretics in the Medical Management of Ménière’s Disease
Authors: Crowson Matthew G. , Patki Aniruddha , Tucci Debara L. 
Published: March 2016

Objective(1) Review evidence for the use of oral diuretic medications in the management of Ménière’s disease. (2) Analyze therapy‐related hearing and vertigo outcomes.Data SourcesLiterature was obtained through directed searches of MEDLINE, EMBASE, Web of Science, EBSCO Host, Cochrane Reviews, and linked citations through seminal papers. We searched independent electronic databases for articles that reported the use of diuretics in patients with Ménière’s disease.Review MethodsAll articles of level 4 evidence or higher, per the Oxford Centre for Evidence‐Based Medicine, were included with no limit for number of patients, duration of therapy, or follow‐up period. Two independent investigators reviewed the articles for inclusion eligibility. Outcomes were tabulated, including subjective or quantitative measures of hearing, tinnitus, vertigo episode frequency, and medication adverse effects.ResultsNineteen articles were included from 1962 to 2012 from 11 countries. Twelve retrospective case series, 4 randomized controlled trials, 2 case‐control trials, and 1 prospective case series were identified. Six studies investigated isosorbide; 5, hydrochlorothiazide; 2, acetazolamide; 2, chlorthalidone; and 1 each of betahistine, hydrochlorothiazide, chlorthalidone, acetazolamide, hydrochlorothiazide‐triamterene, and nimodipine. Eight (42.1%) studies reported hearing outcomes improvement. Fifteen (79.0%) studies reported vertigo outcomes improvement. Ten (52.6%) studies reported no side effects, and 4 studies (21.1%) reported abdominal discomfort. No significant morbidity or mortality was reported in any study.ConclusionMultiple low evidence–level studies report that oral diuretic therapy may be beneficial in the medical management of Ménière’s disease. Improvement in vertigo episode frequency was consistently reported, with less convincing evidence for improvement in hearing outcomes.
Trends in the Incidence of Oropharyngeal Cancers in the United States
Authors: Enomoto Laura M. , Bann Darrin V. , Hollenbeak Christopher S. , Goldenberg David 
Published: March 2016

ObjectiveThe incidence of oropharyngeal squamous cell carcinoma (SCCa) has increased in the United States despite a decrease in tobacco usage, and it may be driven by an increase in oral human papilloma virus (HPV) infection. We studied the incidence of tongue base and tonsillar SCCa over time to understand the changing epidemiology of oropharyngeal SCCa.SettingLarge national tumor registry.Subjects and MethodsWe studied patients diagnosed with oropharyngeal SCCa in SEER data (Surveillance, Epidemiology, and End Results) from 1973 to 2009. Age‐adjusted incidence rates standardized to the 2000 US population were computed, with stratifications for age, sex, race, and stage.ResultsThe sample included 10,061 tongue base and 11,515 tonsillar oropharyngeal cancers. When stratified by age, the incidence of oropharyngeal SCCa in patients ≤55 years of age more than doubled over 30 years. While the incidence rate in females remained stable, the rate in males more than doubled, from 2 per 100,000 persons in 1973 to >4 per 100,000 persons in 2009. The age‐adjusted incidence of oropharyngeal SCCa in patients of black race/ethnicity remained consistently elevated, but the incidence in patients of white race/ethnicity rose from 1.3 per 100,000 persons to >2.5 per 100,000 persons, surpassing the incidence in black patients starting in 2002.ConclusionThe observation that the incidence of oropharyngeal SCCa is increasing among younger white males, despite a reduction in tobacco usage in the United States, is consistent with HPV as the source. Primary and secondary prevention strategies may be warranted in this population.
Associations of Volume and Thyroidectomy Outcomes
Authors: Liang Tsung‐Jung , Liu Shiuh‐Inn , Mok King‐Tong , Shi Hon‐Yi 
Published: March 2016

ObjectiveThis study explored how different hospital volumes and surgeon volumes affect thyroidectomy outcomes in terms of length of stay (LOS), costs, and in‐hospital mortality.Data SourcesMEDLINE and EMBASE databases.Review MethodsThis study retrospectively analyzed a cohort of 125,037 thyroidectomy patients treated at Taiwan hospitals from 1996 to 2010. Relationships between hospital/surgeon volume and patient outcomes were retrospectively analyzed by propensity score matching. In conjunction with the retrospective study, a systematic review and meta‐analysis of the relevant literature also were performed.ResultsThe mean LOS for all thyroidectomies performed during the study period was 3.3 days, and the mean cost was $1193.5. Both high‐volume hospitals and high‐volume surgeons were associated with significantly shorter LOS and lower costs compared with their low‐volume counterparts (P <. 001). Different volume groups had similar in‐hospital mortality rates. The meta‐analysis results consistently showed that the benefits of high‐volume hospitals/surgeons are reduced LOS and costs. However, low in‐hospital mortality rates were associated with high‐volume surgeons but not with high‐volume hospitals.ConclusionsThis meta‐analysis showed that patients who received thyroidectomies performed by high‐volume hospitals and surgeons had shorter LOS and lower costs compared with those treated by low‐volume hospitals and surgeons. In addition, in‐hospital survival rates were better in patients treated by high‐volume surgeons. Further research is needed to define the learning curve for thyroidectomy and to clarify how hospital volume and surgeon volume affect its success rate.
A Charge Comparison of Audiometric Testing in the Pediatric Population
Authors: Trosman Samuel J. , Geelan‐Hansen Katie , Anne Samantha 
Published: March 2016

ObjectiveTo determine the charges associated with performing combined tympanometry and otoacoustic emissions vs a comprehensive audiogram in the pediatric population and to analyze its implications for future practice.Study DesignRetrospective charge analysis.SettingTertiary care academic center.Subjects and MethodsAnalysis was performed on 538 pediatric patients who underwent audiometric hearing testing from May through October 2014.ResultsIn total, 401 patients had combined tympanometry and otoacoustic emissions testing and 91 patients underwent a comprehensive audiogram, while 46 patients underwent all 3 tests. The technical and professional charges for combined tympanometry and otoacoustic emissions were $139 and $116, respectively, with an overall charge of $255. The technical and professional charges for an audiogram were $124 and $198, respectively, with an overall charge of $322.ConclusionObjective testing with a combination of tympanometry and otoacoustic emissions charges insurers $67 less than an audiogram. Given the questionable reliability of behavioral audiometry in very young children, this is a factor to consider when choosing the appropriate test. With a large number of pediatric auditory hearing tests performed each year, the cost savings within the health care system could be substantial.
Placebo caffeine reduces withdrawal in abstinent coffee drinkers
Authors: Mills Llewellyn , Boakes Robert A , Colagiuri Ben 
Published: March 2016

Background: Expectancies have been shown to play a role in the withdrawal syndrome of many drugs of addiction; however, no studies have examined the effects of expectancies across a broad range of caffeine withdrawal symptoms, including craving. Aims: The purpose of the current study was to use caffeine as a model to test the effect of expectancy on withdrawal symptoms, specifically whether the belief that one has ingested caffeine is sufficient to reduce caffeine withdrawal symptoms and cravings in abstinent coffee drinkers. Methods: We had 24-h abstinent regular coffee drinkers complete the Caffeine Withdrawal Symptom Questionnaire (CWSQ) before and after receiving decaffeinated coffee. One-half of the participants were led to believe the coffee was regular caffeinated coffee (the ‘Told Caffeine’ condition) and one-half were told that it was decaffeinated (the ‘Told Decaf’ condition). Results: Participants in the Told Caffeine condition reported a significantly greater reduction in the factors of cravings, fatigue, lack of alertness and flu-like feelings of the CWSQ, than those in the Told Decaf condition. Conclusions: Our results indicated that the belief that one has consumed caffeine can affect caffeine withdrawal symptoms, especially cravings, even when no caffeine was consumed.
The face validity and clinical utility of the Activity Card Sort – United Kingdom (ACS-UK)
Authors: Laver-Fawcett Alison , Brain Leanne , Brodie Courtney , Cardy Lauren , Manaton Lisa 
Published: March 2016

Introduction The Activity Card Sort – United Kingdom version is a self-report interview assessment requiring older adults to sort activity photograph cards to evaluate their levels of participation. The face validity and clinical utility of the activity card sort – United Kingdom were explored. Method The sample comprised 27 community dwelling older adults (>65 years) and eight assessors. The Activity Card Sort – United Kingdom was administered, followed by a semi-structured interview to explore participants' opinions and experiences of undertaking the assessment. Time taken to administer and score was measured. Results Mean administration and scoring time was 14 minutes and 30 seconds, which was considered reasonable by older people and assessors. The majority of participants found the Activity Card Sort – United Kingdom straightforward, easy to do and considered activities and activity labels clear. All participants considered that photographs looked like the activities they were depicting. Participants made recommendations which have led to some improvements to the assessment. Conclusion The Activity Card Sort – United Kingdom has good clinical utility in terms of ease of use and time required for administering and scoring the assessment. Face validity, in terms of acceptability, was good, but more detailed instructions in the manual will be required to guide therapists on how to explain the purpose of the assessment to clients.
Prevalence of Knee Osteoarthritis in 100 Athletically Active Veteran Soccer Players Compared With a Matched Group of 100 Military Personnel
Authors: Paxinos Odysseas , Karavasili Alexandra , Delimpasis Georgios , Stathi Afroditi 
Published: March 2016

Background: Although knee injuries in professional soccer (football) have been extensively studied, the prevalence of knee osteoarthritis (OA) in veteran players is not well documented. Purpose: To investigate the prevalence of knee OA in retired professional soccer players in comparison with a group of athletically active military personnel. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A group of 100 veteran Greek soccer players aged 35 to 55 years (mean [±SD] age, 46.90 ± 5.9 years) were examined for knee OA and were administered the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire. A matched group of 100 athletically active military personnel served as a comparison group. Results: The sonographic prevalence of OA was significantly higher in the veteran soccer group (52%) than in the military group (33%) (n = 200; P = .010). This difference remained significant even after excluding participants with a history of knee surgery (44.1% vs 25.3%, respectively) (n = 151; P = .010). Femoral cartilage thickness was similar between the 2 groups ( P = .473), while altered knee alignment had no effect on the prevalence of OA ( P = .740). With the exception of perceived pain being more prevalent in the military group, there were no other statistically significant differences between the 2 groups in KOOS values. Conclusion: Veteran soccer players had a higher sonographic prevalence of knee OA but better pain scores than a matched group of athletically active military personnel.
Learning Differences Between 3D vs. 2D Entertainment and Educational Games
Authors: Koops Martijn C. , Verheul Ineke , Tiesma Rinus , de Boer Cees-Willem , Koeweiden Ruben T. 
Published: March 2016

Background. Many physics concepts can be abstract and difficult to learn from books or lectures. Experiments are frequently used to overcome such difficulties and provide a sound learning experience. However, some concepts may not be experienced through experimentation or may not be experienced in real life. Recently, computer games, based on physics simulations, have been utilized to provide an alternative learning tool. Aim. Educational games designed to overcome misconceptions have proven to provide an effective alternative learning option. In this research, the authors investigate if commercial entertainment games can be used to overcome misconceptions of Newton’s laws of motion as well. Method. The application of a commercial entertainment game as an effective learning tool in physics education is compared with a self-designed, 2-dimensional game. Results. Self-designed educational games induce a significantly higher learning gain than the commercial entertainment game. Conclusions and Recommendations. For teaching specific concepts using educational games, special-purpose games may produce larger learning gains.
Investigating the Winner’s Curse Based on Decision Making in an Auction Environment
Authors: Karl Christian K. 
Published: March 2016

Background. The majority of bidding models, such as those developed by Friedman and Gates focus on the mark-up decision. Despite a large body of literature, particularly related to the construction industry, these bidding models largely ignore human behavior. Aim. This article has two aims. The first is to contribute to the potential use of business games to study the results of auction behavior in a construction business environment. The second is to investigate the winner’s curse and its effects on individual companies and the market. Method. The methodology for this study is rooted in game theory. The reasoning which leads to the winner’s curse is explored through a behavioral multi-actor experiment. I developed a database-driven, online multiplayer auction game which served as a laboratory experiment. The study included 42 participants. Data were collected during the game, and debriefing results were analyzed. Results. The results show that contractors suffer from the winner’s curse for a variety of reasons including their own bidding strategy, strong competition within the construction market, and inaccurate estimates of project costs. These reasons affect the behavior of contractors and the intention to win the project’s bid as well as their willingness to take risks. Conclusion and Recommendations. The approach outlined in this article contributes to decision-making research in the context of the ‘reverse’ auction low bid method. I recommend that future researchers consider second-price, sealed-bid auctions (Vickrey auctions); this type of auction is also easy to implement.