bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotic and Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy, Multicenter Study From Saudi Arabia
Authors: Alyami Mohammad , Abdulrahem Abdullah Muhammed , Alqannas Mashhour , AlHabes Hessa , Alyami Awad , Alshammari Sulaiman , Guiral Delia Cortes , Alzamanan Mahdi , Alzahrani Nayef , Bin Traiki Thamer 
Published: September 2024

ABSTRACTBackgroundPeritoneal metastasis (PM) is a common evolution of abdominal tumors. Without aggressive multimodal treatment, it is associated with a poor prognosis. The aim of this study is to present a multicenter results from Saudi Arabia on minimally invasive CRS and HIIPEC.MethodsA retrospective analysis of a prospective maintained multicenter database was queried for all patients treated with laparoscopic or robotic CRS and HIPEC between 2019 and 2024 in Saudi Arabia. Surgical and oncological outcome was analyzed.ResultsEleven consecutive patients underwent minimally invasive CRS and HIPEC between 2019 and 2024. Eight patients (72.7%) were operated by laparoscopy, one of them by single port access and three patients (27.3%) were operated robotically. Six patients (54.5%) were female. Median age was 42 (29–64). Primary tumor was PMP from the appendix, colon, and MCM in 6 (54.5%), 4 (36.4%), and 1 (9.1%) respectively. The median duration to complete the surgical procedure for all patients was 330 (230–580) min and for robotic CRS the median docking time was 570 (330–580) min. Median PCI was 2 (1–7) and completeness Cytoreduction (CC score 0) was achieved in the all patients (100%). Median hospital stay was 8 days (3–20). Four patients had one night postoperative ICU stay. Major morbidity (CTCAE) 3 and 4 occurred in three patients (27.3%) (Port site hernia, bleeding, and wound infection). No readmission to the hospital and no 90 days mortalities.ConclusionThe minimally invasive approach by laparoscopy or robot is a feasible and promising option for CRS and HIPEC. It reduces the hospital stay, early return to intended oncological treatment (RIOT). Further prospective clinical studies are needed to evaluate this approach.
Good rate of satisfaction but suboptimal clinical outcome at long‐term follow‐up in a large series of patients who had operative stabilization of the deltoid ligament of the ankle
Authors: Krogsgaard Michael Rindom , Palm Henrik , Obionu Kenneth , Astrup Yvette , Lange Naja Bjørslev , Haak Tobias , Dippmann Christian 
Published: September 2024

AbstractPurposeTo report results following deltoid ligament reconstruction in a large series of patients.MethodsFor consecutive patients who had a medial ankle ligament stabilization 2010–2018 information from their medical files was registered, and they were invited for follow‐up in 2021–2022. They answered questions about satisfaction with the treatment and current symptoms, and they completed the Foot and Ankle Measurement (FAAM) questionnaire.ResultsOf the 503 patients, 342 (68%) had a history of trauma to the ankle and 114 (23%) had previous ankle surgery. 67% had other procedures (besides synovectomy) simultaneous to medial ligament reconstruction. 269 patients (54%) responded to the invitation for follow‐up. For 182 (71%) of the responders, the operation solved their ankle problems. 163 (63%) were satisfied with the surgery. 192 (71%) would repeat the operation. 173 (67%) had pain in the ankle during the past week, and 86 (50%) of these were not able to run. FAAM ADL‐scores were significantly higher than in a mixed group of ankle/foot patients but not normal.ConclusionThe relatively high degree of satisfaction despite suboptimal clinical results may reflect the complex nature of the deltoid ligament insufficient ankle. It is concluded that repair or reconstruction of the deltoid ligament is only performed in patients reporting ankle instability and with peroperatively demonstrated medial instability and pathology to the ligament.Level of EvidenceLevel III.
Design of a LiDAR ranging system based on dual‐frequency phase modulation
Authors: Mu Yuanhui , Feng Shanshan , Liu Ruzhang , Liu Luyin , Wang Shuying , Cai Enlin 
Published: September 2024

AbstractPhase‐based light detection and ranging (LiDAR) technology is emerging in the fields of industrial mapping, autonomous driving, and robotics, but the traditional phase‐based ranging technology generally suffers from the problem that the ranging accuracy is inversely proportional to the measurement range under a single measurement frequency, the system structure is complicated, and the performance is unstable, and so forth. In this article, a new type of LiDAR system design based on phase ranging is proposed. The system adopts a 100 + 1 MHz double measuring ruler modulation light source, uses the laser to control the phase difference detection method of the same frequency reference, optimizes the structure of the transceiver optical system, and the design of AD8302 high‐resolution signal phase discriminator circuit, builds a high‐precision laser ranging system, and carries out the experiments on the measurement accuracy of the LiDAR ranging system. The experimental results show that the measurement accuracy of the system is millimeter level, which is simple, practical, and can meet the needs of a wide range of practical applications. This study provides a feasible and innovative solution for LiDAR technology in high‐precision distance measurement.
Scatterer spacing based on Gabor atoms matched from harmonic ultrasound echoes to improve assessment of microwave‐induced thermal lesions
Authors: Zeng Xiuhua , Zhang Yufeng , Li Zhiyao , Yang Jian , Gao Lian , Zhang Junhua 
Published: September 2024

AbstractBackgroundMicrowave ablation (MWA) is a minimally invasive alternative for the treatment of unresectable liver tumors. To verify the effectiveness and safety of MWA, it is critical to measure the temperature variation and assess the regions of the microwave‐induced thermal lesions.PurposeRecent studies have indicated that the locations of optimally matched Gabor atoms (LOMGA) from ultrasound radiofrequency (RF) echo signals allow accurate and stable scatterer spacing estimation. Herein, a harmonic‐based LOMGA method is proposed to estimate the scatterer spacing for improving the assessment of microwave‐induced thermal lesions.MethodsThe mean scatterer spacing (MSS) is estimated via the LOMGA method incorporating the selection of concise atoms from separated second‐harmonic RF echo signals with the pulse‐inversion algorithm for thermal lesion evaluation. In vitro experiments, 10 fresh porcine liver samples were ablated at different time nodes during the ablation period, and 200 sets of second‐harmonic and fundamental RF echo signals were randomly selected from the regions of interest in the coagulated liver samples for MSS estimation. The means and standard deviations of the MSSs, as well as the linear regression for the mean MSSs, were calculated from fundamental and second‐harmonic signals for comparison and evaluation, the receiver operating characteristic (ROC) curves for the 200 sets of fundamental‐based and harmonic‐based MSS estimates from the 10 liver samples at five pairs of adjacent time nodes were calculated, and one‐way analysis of variance (ANOVA) tests were performed for the five pairs of adjacent time nodes. The fundamental and harmonic‐based p‐values in the ANOVA tests and the areas under the ROC curves (AUCs) were calculated to statistically analyze the differences in the MSSs between adjacent time nodes.ResultsThe harmonic‐based increments in the intensity variation and coherent components were larger than the fundamental‐based increments with the increasing ablation time. The harmonic‐based MSSs from the 10 liver samples at five pairs of adjacent time nodes were found to be highly statistically significant (p < 0.01). Thus, the harmonic‐based MSSs had greater variations. Compared with the fundamental‐based results, for the five preset ST values, the average increment in the harmonic‐based mean slopes was 69.22% and the average decrement in the mean standard deviations was 11.67% for the linear‐fitting MSS results, and the results were statistically significant (p < 0.05).ConclusionHarmonic‐based MSSs are more sensitive and robust to variations in coagulated tissues, which is advantageous for the assessment of microwave‐induced thermal lesions.
Access for ALL in ALS: A large‐scale, inclusive, collaborative consortium to unlock the molecular and genetic mechanisms of amyotrophic lateral sclerosis
Authors: Berry James D. , Paganoni Sabrina , Harms Matthew B. , Shneider Neil , Andrews Jinsy , Miller Timothy M. , Babu Suma , Sherman Alex V. , Harris Brent T. , Provenzano Frank A. , Phatnani Hemali P. , Shefner Jeremy , Garret Mark A. , Ladha Shaffeeq S. , Tsou Amy Y. , Mohan Praveena , Igne Courtney ,   The ALL ALS Consortium, Bowser Robert 
Published: September 2024

AbstractRecent progress in therapeutics for amyotrophic lateral sclerosis (ALS) has spurred development and imbued the field of ALS with hope for more breakthroughs, yet substantial scientific gaps persist. This unmet need remains a stark reminder that innovative paradigms are needed to invigorate ALS research. To move toward more informative, targeted, and personalized drug development, the National Institutes of Health (NIH) established a national ALS clinical research consortium called Access for ALL in ALS (ALL ALS). This new consortium is a multi‐institutional effort that aims to organize the ALS clinical research landscape in the United States. ALL ALS is operating in partnership with several stakeholders to operationalize the recommendations of the Accelerating Access to Critical Therapies for ALS Act (ACT for ALS) Public Private Partnership. ALL ALS will provide a large‐scale, centralized, and readily accessible infrastructure for the collection and storage of a wide range of data from people living with ALS (symptomatic cohort) or who may be at risk of developing ALS (asymptomatic ALS gene carriers). Importantly, ALL ALS is designed to encourage community engagement, equity, and inclusion. The consortium is prioritizing the enrollment of geographically, ethnoculturally, and socioeconomically diverse participants. Collected data include longitudinal clinical data and biofluids, genomic, and digital biomarkers that will be harmonized and linked to the central Accelerating Medicines Partnership for ALS (AMP ALS) portal for sharing with the research community. The aim of ALL ALS is to deliver a comprehensive, inclusive, open‐science dataset to help researchers answer important scientific questions of clinical relevance in ALS.
Self‐regulation and self‐efficacy of EFL learners in hybrid educational settings in Türkiye
Authors: Kaptanoğlu Mehmet Yağız , Kavanoz Suzan 
Published: September 2024

AbstractDistance learning, online learning and hybrid learning models have been a part of language education for a long time. The adoption of these models and research focusing on related phenomena have become even more frequent since the breakout of the COVID‐19 pandemic in 2019. This mixed‐method study examines the relationship between online learning self‐efficacy and online self‐regulation of preparatory class English as a Foreign Language (EFL) learners to provide a picture of the learners' perspective regarding the online segment of the hybrid education system that was in effect during the mentioned era, to provide deeper insights regarding learner perceptions during such times of emergency. Turkish adaptations of the Online‐Learning Self‐Efficacy Scale and Online Self‐regulated Learning Questionnaire were utilized as data collection instruments. To validate and expand the content of quantitative findings, semi‐structured interviews were conducted with a selected group of participants. The findings reveal that preparatory year Turkish EFL learners perceive themselves to be self‐efficacious and self‐regulated at a satisfactory level in online learning environments. The study provides insight into the learners' perceptions during this period and contributes to filling a significant gap within the field as well as offering new perspectives in case we face similar conditions in the future.
A single‐center retrospective review of metastatic prostate cancer on PSMA position emission tomography/computed tomography: Beyond lymph nodes and bones
Authors: De Jesus Gabriela N. C. , Pereira Veronica , Karak Prasanta , Shearier Emily 
Published: September 2024

AbstractBackgroundProstate‐specific membrane antigen (PSMA) Positron emission tomography/computed tomography (PET/CT) has become a crucial imaging modality for the staging of patients with prostate cancer. The purpose of this study is to retrospectively determine the frequency, anatomical distribution, and clinical‐pathologic correlates of extra‐nodal and extra‐osseous metastatic prostate cancer detected on PSMA PET/CT.MethodsAll available 650 PSMA PET/CT performed in patients with biopsy‐proved prostate cancer in our institution between September 2021 and December 2023 were reviewed for the presence of extra‐nodal and extra‐osseous metastatic disease (M1C disease). Thirty‐four patients with M1C disease were identified.ResultsThe most frequent sites of visceral/soft tissue metastases were the lungs (58.8%), liver (23.5%) and adrenal glands (20.6%). 75% of patients with lung metastases detected on PSMA PET/CT had concurrent intrathoracic lymph node involvement. A higher frequency of patients with M1C disease (55.9%) had a high Gleason score. The median prostate‐specific antigen (PSA) level at the time of the PSMA scan was 20.16 ng/mL. There was a statistically significant association between PSA level and osseous disease (p = 0.004), as well as PSA level and nodal disease (p = 0.008). While a large number of patients had concurrent osseous and nodal disease (82.4% and 79.4%, respectively), no visceral/soft tissue sites demonstrated a significant association with the presence of osseous or nodal involvement.ConclusionsGiven the increasing utilization of PSMA PET/CT, increased knowledge of the location and pattern of distribution of visceral/soft tissue metastatic sites is crucial not only for staging but also to better understand patterns of therapeutic response. We identified the lungs, liver and adrenal glands as the most common visceral/soft tissue metastatic sites from prostate cancer. We found that higher PSA levels at the time of PSMA PET/CT imaging were positively associated with concurrent osseous and nodal involvement.
Deep PSA response and extended time‐to‐nadir as robust predictors of survival in Asian patients with de novo metastatic hormone‐sensitive prostate cancer receiving upfront intensified treatment
Authors: Wong Chris H.‐M. , Ko Ivan C.‐H. , Leung David K.‐W. , Siu Brian , Cheng Cheuk‐K. K. , Lim Yung‐Y. J. , Mok Hiu T. , Kwok Chun‐F. B. , Tang Cheuk Y. , Leung Steven C.‐H. , Chiu Peter K.‐F. , Teoh Jeremy Y.‐C. , Ng Chi F. 
Published: September 2024

AbstractIntroductionIn de novo metastatic hormone‐sensitive prostate cancer (mHSPC) treated with upfront intensification using androgen receptor signaling inhibitor or chemotherapy (Docetaxel), achieving a PSA nadir less than 0.2 ng/mL, indicative of superior survival in trials, may often be unattainable in real‐world settings. We explored the predictive value of the degree of PSA decline and time to PSA nadir (TTPN) on oncological outcomes.MethodsA prospectively maintained database of consecutive prostate cancer cases in Hong Kong was accessed. Patients diagnosed with de novo mHSPC from 2016 to 2022 and treated with upfront intensification were included in this analysis. Landmark analysis on PSA kinetics at 6‐months following treatment intensification was performed. They were classified based on 1) TTPN (≥6 months vs. <6 months), and 2) a combined response (deep responders achieving both ≥95% PSA decline and TTPN ≥ 6 months vs. shallow responders). Multivariable regression analysis was employed to identify the effects of confounders.FindingsA total of 131 patients were included in this analysis. Classifying patients by combined response best predicted survival outcomes. Deep responders had better progression‐free survival (HR = 0.56; 95%CI = 0.34–0.91; p = 0.019), overall survival (HR = 0.50; 95%CI = 0.26–0.97; p = 0.036), and cancer‐specific survival (HR = 0.43; 95%CI = 0.19–0.99; p = 0.042). Difference in overall survival remained significant after adjustment in multivariable regression analysis.ConclusionOur analysis demonstrates that alternative PSA targets can predict treatment response and survival outcomes in de novo mHSPC patients in a real‐world setting, providing valuable information for patient counselling and potentially guiding future trial design.
Population pharmacokinetic–pharmacodynamic model of elinzanetant based on integrated clinical phase I and II data
Authors: Willmann Stefan , Lloyd Adam , Austin Rupert , Joseph Shiju , Solms Alexander , Zhang Yang , Schneider Annika R. P. , Frechen Sebastian , Schultze‐Mosgau Marcus‐Hillert 
Published: September 2024

AbstractElinzanetant is a potent and selective dual neurokin‐1 (NK‐1) and ‐3 (NK‐3) receptor antagonist that is currently developed for the treatment of women with moderate‐to‐severe vasomotor symptoms (VMS) associated with menopause. Here, we report the development of a population pharmacokinetic (popPK) model for elinzanetant and its principal metabolites based on an integrated dataset from 366 subjects (including 197 women with VMS) collected in 10 phase I or II studies. The pharmacokinetics of elinzanetant and its metabolites could be well described by the popPK model. Within the investigated dose range of 40–160 mg, the oral bioavailability of elinzanetant was dose independent and estimated to be 36.7%. The clearance of elinzanetant was estimated to be 7.26 L/h and the central and peripheral distribution volume were 23.7 and 168 L. No intrinsic or extrinsic influencing factors have been identified in the investigated population other than the effect of a high‐fat breakfast on the oral absorption of elinzanetant. The popPK model was then coupled to a pharmacodynamic model to predict occupancies of the NK‐1 and NK‐3 receptors. After repeated once‐daily administration of the anticipated therapeutic dose of 120 mg elinzanetant, the model‐predicted median receptor occupancies are >99% for NK‐1 and >94.8% for NK‐3 during day and night‐time, indicating sustained and near‐complete inhibition of both target receptors during the dosing interval.
Procyanidin B1 Promotes PSMC3‐NRF2 Ubiquitination to Induce Ferroptosis in Glioblastoma
Authors: Gao Wei , Li Yuan , Lin Xiang , Deng Kun , Long Xinmiao , Li Danyang , Huang Meng , Wang Xiangyu , Xu Yucong , She Xiaoling , Wu Minghua 
Published: September 2024

ABSTRACTNRF2 signaling is a crucial antioxidant defense mechanism against ferroptosis in tumors, and targeting NRF2 is essential for tumor therapy. However, the effectiveness of NRF2 inhibitors remains unexplored. The active ingredients of traditional Chinese medicine serve as important sources of NRF2 inhibitors. In this study, we established an intracranial glioblastoma (GBM) orthotopic model and observed the effects of procyanidin B1 on tumor growth and ferroptosis. Using protein‐small‐molecule docking, z‐stack assay of laser confocal imaging, surface plasmon resonance assay, immunoprecipitation, mass spectrometry, and western blotting, we detected the binding between procyanidin B1 and NRF2 and the effect of PSMC3 on the ubiquitin‐dependent degradation of NRF2 in GBM cells. Our results showed that procyanidin B1 acted as a novel NRF2 inhibitor to suppress GBM cell proliferation and prolonged the survival of GBM‐bearing mice; it also mediated the interaction between PSMC3 and NRF2 to promote ubiquitin‐dependent protein degradation of NRF2, which induced ferroptosis in GBM cells. In addition, we found that procyanidin B1 enhanced H₂O₂ accumulation by downregulating NRF2 during ferroptosis in GBM cells. The botanical agent procyanidin B1 induced ferroptosis and exerted anti‐tumor effects through PSMC3‐mediated ubiquitin‐dependent degradation of NRF2 proteins, providing a potential drug candidate for adjuvant therapy in patients with GBM.
Influence of Pumping Laser Intensity Uniformity on Hybrid Optically Pumped Comagnetometer in the SERF Regime
Authors: Ma Longyan , Liu Ye , Pang Haoying , Quan Jiale , Ge Xiaohan , Duan Lihong , Quan Wei 
Published: September 2024

AbstractThe effect of pumping laser intensity uniformity (PLIU) on the operation of a hybrid optically pumped comagnetometer operating in the spin‐exchange relaxation‐free regime (SERF) regime is investigated in this paper. First, an analytical steady‐state output model for the comagnetometer with two alkali‐metal atoms and one noble‐gas atom is presented. By varying the diameter of the pumping laser beam to control the PLIU, 3D distribution models of the electron spin and nuclear spin polarization under different PLIU conditions are obtained. In the experiment, the effects of PLIU on multi‐parameter, low‐frequency magnetic‐noise suppression capability, and long‐term stability of the SERF comagnetometer are studied. The results indicate that within a certain range, increasing the diameter of the pumping laser beam improves the polarization uniformity of the atomic ensemble and reduces the light shift of the comagnetometer. As a result, both the low‐frequency magnetic noise suppression capability and the long‐term stability of the system increase. However, further reduction of the pumping laser diameter leads to a reversal of the system performance metrics, suggesting the presence of a tipping point. The research presented in this article is critical for advancing the efficient polarization study and hyperpolarization of SERF comagnetometers.
Pulmonary Langerhans cell histiocytosis with multiple cavitary nodules after lung cancer surgery
Authors: Sugihara Minoru , Okamoto Sawako , Taniguchi Tetsuo 
Published: September 2024

AbstractPulmonary Langerhans cell histiocytosis (PLCH) is a subtype of Langerhans cell histiocytosis, a rare neoplastic disease characterized by lung involvement. Here, we present a case involving a patient with multiple cavitary nodules who was diagnosed with PLCH during surveillance after lung cancer surgery. A 74‐year‐old woman underwent right upper lobe resection surgery for right upper lobe lung adenocarcinoma, pStage IIA, 5 years ago. The patient underwent surveillance without adjuvant chemotherapy. During the fifth year of follow‐up, multiple nodules with cavitation were observed on computed tomography in both lung fields. Chemotherapy was considered to address the suspected recurrence of lung cancer; however, video‐assisted thoracoscopic surgery was performed due to the need for biomarker testing. Pathological examination led to the diagnosis of PLCH. This case emphasizes the importance of a proactive histological diagnosis to determine the appropriate treatment strategy, even in situations where lung cancer recurrence is clinically suspected.
Concurrent learning for adaptive pontryagin's maximum principle of nonlinear systems with inequality constraints
Authors: Zhang Bin , Zhang Yuqi , Jia Yingmin 
Published: September 2024

AbstractIn this article, a finite‐horizon adaptive Pontryagin's maximum principle is presented for nonlinear systems with state inequality constraints. Concurrent learning (CL) technique is adopted to identify the unknown parameters of the dynamic systems. Based on the identification model, a novel adaptive iterative algorithm under the Pontryagin's framework is introduced to learn the finite‐horizon optimal control solution. Convergence analysis of the algorithm is provided by showing that the cost function sequence is monotonically decreasing. Furthermore, we extend the adaptive iterative algorithm to time‐varying nonlinear systems. The new algorithm overcomes the technical obstacles of the existing adaptive/approximate dynamic programming (ADP) approaches to deal with the time‐varying characteristic of Hamilton–Jacobi–Bellman (HJB) partial differential equation (PDE), especially when state constraints exist. Simulation examples are carried out to validate the effectiveness of the theoretical results.