bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of iodine in excess on seminiferous tubular structure and epididymal sperm character in male rats
Authors: Chandra Amar K , Chakraborty Arijit 
Published: February 2017

AbstractExcess iodine induced public health problems are now emerging in many iodine sufficient regions for indiscriminate intake of iodine through various iodized products. It has been reported that excess iodine can disrupt overall male reproductive physiology by generating oxidative stress in the testis. However, information on the possible effect of iodine in excess on spermatozoa found less. In the present investigation flow cytometric techniques and scanning electron microscopy (SEM) have been used to study the spermatozoal functional as well as structural status under the influence of excess iodine; generation of ROS in the spermatozoa as evident by DCFDA, altered acrosomal integrity as observed by fluorescence lectin staining method and depolarized mitochondrial membrane potential (ΔΨm) noticed by JC‐1 staining. Ultrastructure of seminiferous tubule after excess iodine exposure indicated severe deterioration of seminiferous tubular surface architecture. Significant increase in spermatozoal DNA fragmentation and apoptotic sperms were found by acridine orange and Annexin V, respectively, however the plasma membrane integrity/viability was decreased as evident by propidium iodide staining in various incremental doses and durations under iodine excess. The study reveals that excess iodine could cause apoptosis of spermatozoal cells by inducing ROS that ultimately affects male fertility potential.
Inborn errors of metabolism associated with psychosis: literature review and case–control study using exome data from 5090 adult individuals
Authors: Trakadis Yannis J. , Fulginiti Vanessa , Walterfang Mark 
Published: February 2017

AbstractA literature review was conducted, using the computerized “Online Mendelian Inheritance in Man” (OMIM) and PubMed, to identify inborn errors of metabolism (IEM) in which psychosis may be a predominant feature or the initial presenting symptom. Different combinations of the following keywords were searched using OMIM: “psychosis”, “schizophrenia”, or “hallucinations” and “metabolic”, “inborn error of metabolism”, “inborn errors of metabolism”, “biochemical genetics”, or “metabolic genetics”. The OMIM search generated 126 OMIM entries, 40 of which were well known IEM. After removing IEM lacking evidence in PubMed for an association with psychosis, 29 OMIM entries were identified. Several of these IEM are treatable. They involve different small organelles (lysosomes, peroxisomes, mitochondria), iron or copper accumulation, as well as defects in other met‐abolic pathways (e.g., defects leading to hyperammonemia or homocystinemia). A clinical checklist summarizing the key features of these conditions and a guide to clinical approach are provided. The genes corresponding to each of these con‐ditions were identified. Whole exome data from 2545 adult cases with schizophrenia and 2545 unrelated controls, accessed via the Database of Genotypes and Phenotypes (dbGaP), were analyzed for rare functional variants in these genes. The odds ratio of having a rare functional variant in cases versus controls was calculated for each gene. Eight genes are significantly associated with schizophrenia (p < 0.05, OR >1) using an unselected group of adult patients with schizophrenia. Increased awareness of clinical clues for these IEM will optimize referrals and timely metabolic interventions.
New and Uncommon Fatty Acids in Lipids of Deep‐Sea Foraminifera
Authors: Kharlamenko Vladimir I. , Svetashev Vasily I. , Tarasova Tatyana S. 
Published: February 2017

AbstractFatty acids (FA) of agglutinating foraminifera of two genera, Bathysiphon and Rhabdammina, collected from a depth of 3307–3377 m in the Kuril Basin, Sea of Okhotsk, and adjacent deep‐sea waters of the Pacific Ocean, were analyzed. In lipids of two Bathysiphon species, in addition to common FA typical for marine organisms, the uncommon ∆4 and ∆7 monoenoic acids and ∆4,7‐dienoic acid were found in noticeable amounts. FA of two Rhabdammina species included also such uncommon acids as ∆5,8,11,14–21:4, ∆5,8,11,14–22:4, and ∆5,8,11,14–23:4, which are homologues to arachidonic acid. High levels of cis‐vaccenic and arachidonic acids were typical for lipids of all the studied species. At the same time, we observed a substantial difference in FA composition between members of these two genera. Using GC and GC–MS of FAME, pyrrolidide and DMOX derivatives, the structures of 10 new FA were confirmed: ∆4‐i‐16:1 (1.1–0.6%), ∆7‐i‐21:1 (0.4%), ∆7‐ai‐21:1 (0.3–0.8%), ∆4,11–18:2 (0.3–0.9%), ∆4,7–20:2 (8.8%), ∆7,12–20:2 (0.4–0.6%), ∆4,7–21:2 (0.6%), ∆7,12–22:2 (6.4–2.1%); ∆5,8,11,14–22:4 (1.2–2.0%), and ∆5,8,11,14–23:4 (1.7–2.3%). The origin of the new FA and the role of foraminifera FA in deep‐sea communities are discussed.
The theory contribution of case study research designs
Authors: Ridder Hans-Gerd 
Published: February 2017

AbstractThe objective of this paper is to highlight similarities and differences across various case study designs and to analyze their respective contributions to theory. Although different designs reveal some common underlying characteristics, a comparison of such case study research designs demonstrates that case study research incorporates different scientific goals and collection and analysis of data. This paper relates this comparison to a more general debate of how different research designs contribute to a theory continuum. The fine-grained analysis demonstrates that case study designs fit differently to the pathway of the theory continuum. The resulting contribution is a portfolio of case study research designs. This portfolio demonstrates the heterogeneous contributions of case study designs. Based on this portfolio, theoretical contributions of case study designs can be better evaluated in terms of understanding, theory-building, theory development, and theory testing.
The Impact of Social Marketing Campaigns on Reducing Mental Health Stigma: Results From the 2009–2014 Time to Change Programme
Authors: Sampogna G. , Bakolis I. , Evans-Lacko S. , Robinson E. , Thornicroft G. , Henderson C. 
Published: February 2017

AbstractBackgroundIn England, during 2009–2014 the ‘Time to Change’ anti-stigma programme has included a social marketing campaign (SMC) using mass media channels, social media and social contact events but the efficacy of such approach has not been evaluated yet.MethodsThe target population included people aged between mid-twenties/mid-forties, from middle-income groups. Participants were recruited through an online market research panel, before and after each burst of the campaign (with a mean number of unique participants per each burst: 956.9 ± 170.2). Participants completed an online questionnaire evaluating knowledge [Mental Health Knowledge Schedule (MAKS)]; attitudes [Community Attitudes toward Mental Illness (CAMI)]; and behaviours [Reported and Intended Behaviour Scale (RIBS)]. Socio-demographic data and level of awareness of the SMC were also collected.ResultsA total of 10,526 people were interviewed. An increasing usage of the SMC-media channels as well as of the level of awareness of SMC was found (P < 0.001). Being aware of the SMC was found to be associated with higher score at MAKS (OR = 0.95, CI = 0.68 to 1.21; P < 0.001), at ‘tolerance and support’ CAMI subscale (OR = 0.12, CI = 0.09 to 0.16; P < 0.001), and at RIBS (OR = 0.71, CI = 0.51 to 0.92; P < 0.001), controlling for confounders.ConclusionThe SMC represents an important way to effectively reduce stigma. Taking into account these positive findings, further population-based campaigns using social media may represent an effective strategy to challenge stigma.
TEMPORAL FREQUENCY OF SOIL TEST INFORMATION EFFECTS ON RETURNS TO POTASSIUM FERTILIZATION IN COTTON PRODUCTION
Authors: HARMON XAVIER , BOYER CHRISTOPHER N. , LAMBERT DAYTON M. , LARSON JAMES A. 
Published: February 2017

AbstractLittle research exists on the optimal temporal frequency between soil tests, given empirical data on potassium (K) carryover and its interaction with cotton yield. We evaluate how decreasing the temporal frequency between obtaining K soil test information affects the net present value (NPV) of cotton production. Monte Carlo simulation was used to determine NPV for cotton production using five soil test schedules ranging from soil testing annually to every fifth year. NPV of returns to K was maximized at $7,580/ac. when producers updated soil testing information every 2 years, which was $2/ac. per year greater than annual soil testing.
Exploring the Relations Between Childhood Experiences in Nature and Young Adults’ Environmental Attitudes and Behaviours
Authors: Broom Catherine 
Published: February 2017

AbstractThis article presents the findings of a research study with young adults who explored the connections between their early childhood experiences in nature and their attitudes and actions towards the environment in adulthood. Drawing on E. Wilson's (1984) work, environmental or ecological consciousness is theorised to connect to ecological identity and relates to an individual's deep reflection on, connection to, and engagement with the natural environment. The study's survey tool invited young adults to select various options that described their experiences in nature as children and their views of, and actions towards, the environment in the present. The findings illustrated connections between childhood experiences in nature and later views of, and actions towards, the environment. The correlations between expressed views about caring for the environment and environmentally friendly actions were surprising, however, as actions did not necessarily align with beliefs. The article concludes with recommendations based on the findings, outlining how positive attitudes and actions towards the environment may be fostered in childhood.
Association between geographic range and initial survival of Mesozoic marine animal genera: circumventing the confounding effects of temporal and taxonomic heterogeneity
Authors: Ritterbush Kathleen A. , Foote Michael 
Published: February 2017

AbstractWe investigate the association between geographic range and survival in Mesozoic marine animal genera. Previous work using data from the Paleobiology Database (paleobiodb.org) demonstrated greater survivorship overall among Phanerozoic genera that were widespread during their stage of first appearance, but this relationship did not hold during the Mesozoic. To explore this unexpected result, we consider geographic range in conjunction with temporal variation in survival and variation in survival among higher taxa. Because average range and average survival are negatively correlated among stages, for reasons that are still unclear, and because the data are heavily influenced by cephalopods, which include many wide-ranging and short-lived genera, the effect of geographic range on survival is obscured in the aggregate data. Thus, range is not a significant predictor of survival when data are analyzed in aggregate, but it does have a significant effect when variation in average range and average survival among stages and classes is taken into account. The best-fitting models combine range with both temporal and taxonomic heterogeneity as predictive factors. Moreover, when we take stage-to-stage variation into account, geographic range is an important predictor of survival within most classes. Cephalopod genera must be more widespread than genera in other classes for geographic range to significantly increase odds of survival, and factoring in survival heterogeneity of superfamilies further increases model fit, demonstrating a nested nature in the sensitivity of range and taxonomic aggregation.
How lives became lists and scientific papers became data: cataloguing authorship during the nineteenth century
Authors: CSISZAR ALEX 
Published: February 2017

AbstractTheCatalogue of Scientific Papers, published by the Royal Society of London beginning in 1867, projected back to the beginning of the nineteenth century a novel vision of the history of science in which knowledge was built up out of discrete papers each connected to an author. Its construction was an act of canon formation that helped naturalize the idea that scientific publishing consisted of special kinds of texts and authors that were set apart from the wider landscape of publishing. By recovering the decisions and struggles through which theCataloguewas assembled, this essay aims to contribute to current efforts to denaturalize the scientific paper as the dominant genre of scientific life. By privileging a specific representation of the course of a scientific life as a list of papers, theCataloguehelped shape underlying assumptions about the most valuable fruits of a scientific career. Its enumerated lists of authors’ periodical publications were quickly put to use as a means of measuring scientific productivity and reputation, as well as by writers of biography and history. Although it was first conceived as a search technology, this essay locates theCatalogue’s most consequential legacy in its uses as a technology of valuation.
Deterrent activity of hops flavonoids and their derivatives against stored product pests
Authors: Jackowski J. , Popłoński J. , Twardowska K. , Magiera-Dulewicz J. , Hurej M. , Huszcza E. 
Published: February 2017

AbstractFive flavonoids from hops, two of their derivatives, along with naringenin used as a model compound, were tested for their antifeedant activity against three coleopteran stored product pests: Sitophilus granarius L., Tribolium confusum Duv. and Trogoderma granarium Everts. The introduction, into the tested flavonoid molecules, of additional structural fragments such as prenyl or dimethylpyran moiety, is proposed to significantly alter the deterrent activity of the compounds. The prenyl moiety in flavonoids increased the deterrent activity of these compounds in all three of the grain feeding species used in the tests. It is also concluded that the introduction of dimethylpyran moiety to the flavonoid structure increases its deterrent activity in S. granarius and T. confusum, but in one of the test insects, T. granarium, an increased feeding was observed in response to the introduction of dimethylpyran moiety to the flavonoid structure.
The Minories Eagle: A New Sculpture from London's Eastern Roman Cemetery
Authors: Lerz Antonietta , Henig Martin , Hayward Kevin 
Published: February 2017

ABSTRACTThe limestone sculpture of an eagle firmly clasping a serpent in its beak was recovered from within the eastern Roman cemetery of London on the last day of excavations at 24–26 Minories, EC3 in September 2013. The sculpture, which is dated stylistically to the late first or early second centurya.d., had been carefully buried within the backfill of a roadside ditch no later than the mid-second century. The Minories eagle is one of the finest and earliest examples of freestone sculpture from the London cemeteries and presumably adorned the tomb of a rich and important individual or family located nearby. Petrological analysis of the sculpture has revealed it is carved from oolitic limestone quarried from the south Cotswolds. The article presents the context of the findspot and a detailed description of the eagle sculpture with an in-depth discussion of the iconography of the image and the results of the petrological examination. The Supplementary Material available online (http://journals.cambridge.org/bri) presents an account of the site stratigraphy, integrated with the specialist finds and the environmental reports.
Facets of Pantomime
Authors: Goldenberg Georg 
Published: February 2017

AbstractObjectives: Exploring the nature of defective pantomime in apraxia. Methods: Critical review of behavioral associations and dissociations between defective pantomime, imitation of gestures, and real tool use. Analysis of congruencies between crucial lesions for pantomime, imitation, and tool use. Results: There are behavioral double dissociations between pantomime and imitation, and their cerebral substrates show very little overlap. Whereas defective pantomime is bound to temporal and inferior frontal lesions, imitation is mainly affected by parietal lesions. Pantomime usually replicates the motor actions of real use but on scrutiny there are important differences between the movements of real use and of pantomime that cast doubt on the assumption that pantomime is produced by the same motor programs as actual use. A more plausible proposal posits that pantomime is a communicative gesture that uses manual actions for conveying information about objects and their use. The manual actions are constructed by selection and combination of distinctive features of tools and actions. They frequently include replications of characteristic motor actions of real use, but the main criterion for selection and modification of features is the comprehensibility of the gestures rather than the accurate replication of the motor actions of real use. Conclusions: Pantomime of tool use is a communicative gesture rather than a replication of the motor actions of real use. (JINS, 2017, 23, 121–127)
Troubled Relationships under the GATS: Tensions between Market Access (Article XVI), National Treatment (Article XVII), and Domestic Regulation (Article VI)
Authors: MULLER GILLES 
Published: February 2017

AbstractThe General Agreement on Trade in Services (GATS) was adopted in order to establish meaningful liberalization rules, while preserving the right of Members to regulate. To that end, three provisions form the centerpiece of liberalization: market access (Article XVI GATS), national treatment (Article XVII GATS), and domestic regulation (Article VI GATS). Although these provisions contain different obligations, in certain conditions they can overlap. How this issue is resolved could undermine the delicate balance between liberalization and the right to regulate. As the GATS provides no guidance, the task of determining the applicable rules has been delegated to the World Trade Organization (WTO) adjudicating bodies. This paper examines how the three provisions have been interpreted, and analyzes the most applicable way to address the diversity of barriers to trade in services.
IPHIGÉNIE EN HAÏTI: PERFORMING GLUCK'S PARIS OPERAS IN THE FRENCH COLONIAL CARIBBEAN
Authors: PREST JULIA 
Published: February 2017

ABSTRACTGluck has been hailed as the ‘first truly international opera composer’, but his internationalism is always understood in strictly European terms. This article seeks to expand our understanding of Gluck's international scope beyond Europe and specifically into the French colonial Caribbean. Saint-Domingue (now Haiti) enjoyed the most vibrant theatrical tradition of the entire Caribbean in the eighteenth century, and three of Gluck's Paris operas that had premiered in the 1770s were given there in the 1780s. Performances of these works are examined in turn, with an emphasis on performance practices in the context of local conditions, both social and practical. Gluck's operas are seen to have reached a mixed, though segregated, audience that incorporated some free people of colour, including a small number of black people, and the first documented performance of a singer of colour in a Gluck opera is uncovered. Our understanding of Gluck's reach, reception and status is thus broadened and deepened in some significant ways, and some new areas of research are opened up.
THE IMPERIAL CORONATION OF LEOPOLD II AND MOZART, FRANKFURT AM MAIN, 1790
Authors: GLATTHORN AUSTIN 
Published: February 2017

ABSTRACTIn the autumn of 1790 Mozart undertook the penultimate journey of his life to participate in the coronation of Leopold II as Holy Roman Emperor in Frankfurt am Main. His attendance and performance at this significant imperial gathering were an investment designed to improve his fortunes. But Mozart's gamble failed. Though it was a key political event, and despite its significance as one of Mozart's final sojourns, not much more is known about the music of the Frankfurt coronation. This article offers a new understanding of Leopold II's imperial accession, positing the coronation as a vibrant context for music culture. Contrary to narratives that position Mozart's concert above all others, I argue that this was far from the case according to his contemporaries. During the coronation festivities the city hosted three theatre companies and many celebrated musicians, including Ludwig Fischer, Johann Hässler, Vincenzo Righini, Antonio Salieri and Georg Vogler, among others. Frankfurt was indeed filled with musicians who cooperated with and competed against one another in the hope of attracting substantial audiences comprised of the Empire's elite. Yet for Mozart, whose concert was poorly advertised and unfortunately timed, this competition proved too intense. By investigating the musical and political events of Leopold II's imperial coronation, I assert that Mozart's investment, which had the potential to alter his life forever, was unsuccessful in part because of a rumour that caused his desired audience to leave Frankfurt temporarily the very morning his performance took place.
microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
Authors: Hajarnis Sachin , Lakhia Ronak , Yheskel Matanel , Williams Darren , Sorourian Mehran , Liu Xueqing , Aboudehen Karam , Zhang Shanrong , Kersjes Kara , Galasso Ryan , Li Jian , Kaimal Vivek , Lockton Steven , Davis Scott , Flaten Andrea , Johnson Joshua A. , Holland William L. , Kusminski Christine M. , Scherer Philipp E. , Harris Peter C. , Trudel Marie , Wallace Darren P. , Igarashi Peter , Lee Edmund C. , Androsavich John R. , Patel Vishal 
Published: February 2017

AbstractAutosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of renal failure. Here we identify miR-17 as a target for the treatment of ADPKD. We report that miR-17 is induced in kidney cysts of mouse and human ADPKD. Genetic deletion of the miR-17∼92 cluster inhibits cyst proliferation and PKD progression in four orthologous, including two long-lived, mouse models of ADPKD. Anti-miR-17 treatment attenuates cyst growth in short-term and long-term PKD mouse models. miR-17 inhibition also suppresses proliferation and cyst growth of primary ADPKD cysts cultures derived from multiple human donors. Mechanistically, c-Myc upregulates miR-17∼92 in cystic kidneys, which in turn aggravates cyst growth by inhibiting oxidative phosphorylation and stimulating proliferation through direct repression of Pparα. Thus, miR-17 family is a promising drug target for ADPKD, and miR-17-mediated inhibition of mitochondrial metabolism represents a potential new mechanism for ADPKD progression.
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
Authors: Feng Qiyu , Zhang Chengliang , Lum David , Druso Joseph E. , Blank Bryant , Wilson Kristin F. , Welm Alana , Antonyak Marc A. , Cerione Richard A. 
Published: February 2017

AbstractNon-classical secretory vesicles, collectively referred to as extracellular vesicles (EVs), have been implicated in different aspects of cancer cell survival and metastasis. Here, we describe how a specific class of EVs, called microvesicles (MVs), activates VEGF receptors and tumour angiogenesis through a unique 90 kDa form of VEGF (VEGF90K). We show that VEGF90K is generated by the crosslinking of VEGF165, catalysed by the enzyme tissue transglutaminase, and associates with MVs through its interaction with the chaperone Hsp90. We further demonstrate that MV-associated VEGF90K has a weakened affinity for Bevacizumab, causing Bevacizumab to be ineffective in blocking MV-dependent VEGF receptor activation. However, treatment with an Hsp90 inhibitor releases VEGF90K from MVs, restoring the sensitivity of VEGF90K to Bevacizumab. These findings reveal a novel mechanism by which cancer cell-derived MVs influence the tumour microenvironment and highlight the importance of recognizing their unique properties when considering drug treatment strategies.