bluuebunny/crossref_metadata_2025_split huggingface dataset:
Newborn screening algorithm distinguishing potential symptomatic isovaleric acidemia from asymptomatic newborns
Authors: Rock Rachel , Rock Oded , Daas Suha , Biton‐Regev Vered , Sagiv Nadav , Salah Nasser Abu , Anikster Yair , Barel Ortal , Cohen Ronen Hady , Dumin Elena , Fattal‐Valevski Aviva , Falik‐Zaccai Tzipora , Herskovitz Eli , Josefsberg Sagi , Khammash Hatem , Kneller Katya , Korman Stanley H. , Landau Yuval E. , Lerman‐Sagie Tally , Mandel Hanna , Pras Elon , Reznik‐Wolf Haike , Shaag Avraham , Lotan Nava Shaul , Spiegel Ronen , Tal Galit , Staretz‐Chacham Orna , Wilnai Yael , Almashanu Shlomo 
Published: September 2024

AbstractNewborn screening (NBS) for isovaleric acidemia (IVA) reduces mortality and morbidity; however, it has also resulted in the detection of individuals with an asymptomatic or mild presentation for which early detection via newborn screening has not been proven to alter neurological outcome. We reevaluated biochemical and molecular data for newborns flagged positive for IVA in aim of developing a new screening algorithm to exclude the latter from positive screening. Among 2 794 365 newborns underwent routine newborn screening in Israel, 412 flagged positive for IVA, of which, 371 were false positives on recall sample testing and 41 positive newborns were referred to the clinic. 38/41 have biochemical and molecular confirmation in keeping with IVA. Among the 38 patients, 32% (12/38) were classified as symptomatic while, 68% (26/38) were classified as asymptomatic. 69% of the latter group harbor the known variant associated with mild potentially asymptomatic phenotype, c.932C>T; p. Ala311Val. Among asymptomatic patients, only 46% (12/26) are currently treated. Two novel variants have been detected in the IVD gene: c.487G>A; p. Ala163Thr and c.985A>G; p. Met329Val. Cut‐off recalculation, of referred newborns' initial biochemical results, after classifying the referred patients to two binary groups of symptomatic and asymptomatic, resulted in an improved NBS algorithm comprising of C5 >5 μM and C5/C2>0.2 and C5/C3>4 flagging only those likely to have the classic symptomatic phenotype.
Perspectives Toward an Integrative Structural Biology Pipeline With Atomic Force Microscopy Topographic Images
Authors: Pellequer Jean‐Luc 
Published: September 2024

ABSTRACTAfter the recent double revolutions in structural biology, which include the use of direct detectors for cryo‐electron microscopy resulting in a significant improvement in the expected resolution of large macromolecule structures, and the advent of AlphaFold which allows for near‐accurate prediction of any protein structures, the field of structural biology is now pursuing more ambitious targets, including several MDa assemblies. But complex target systems cannot be tackled using a single biophysical technique. The field of integrative structural biology has emerged as a global solution. The aim is to integrate data from multiple complementary techniques to produce a final three‐dimensional model that cannot be obtained from any single technique. The absence of atomic force microscopy data from integrative structural biology platforms is not necessarily due to its nm resolution, as opposed to Å resolution for x‐ray crystallography, nuclear magnetic resonance, or electron microscopy. Rather a significant issue was that the AFM topographic data lacked interpretability. Fortunately, with the introduction of the AFM‐Assembly pipeline and other similar tools, it is now possible to integrate AFM topographic data into integrative modeling platforms. The advantages of single molecule techniques, such as AFM, include the ability to confirm experimentally any assembled molecular models or to produce alternative conformations that mimic the inherent flexibility of large proteins or complexes. The review begins with a brief overview of the historical developments of AFM data in structural biology, followed by an examination of the strengths and limitations of AFM imaging, which have hindered its integration into modern modeling platforms. This review discusses the correction and improvement of AFM topographic images, as well as the principles behind the AFM‐Assembly pipeline. It also presents and discusses a series of challenges that need to be addressed in order to improve the incorporation of AFM data into integrative modeling platform.
Endoscopic diagnosis of asymptomatic appendicitis in a pediatric patient
Authors: Mostafavi Mojdeh , Katz Aubrey J. 
Published: September 2024

AbstractIncidental diagnosis of asymptomatic appendicitis is exceptionally rare, even more so when identified endoscopically. This is among the first reported cases of appendicitis incidentally diagnosed during colonoscopy in a pediatric patient. Most notably, the identification of subclinical appendicitis allowed for early referral to pediatric surgery for management, which in turn may have prevented progression to acute symptomatic appendicitis.
Unraveling consumer behavior: Exploring the influence of consumer ethnocentrism, domestic country bias, brand trust, and purchasing intentions
Authors: Kinawy Ream Nabil 
Published: September 2024

AbstractThis narrative review examines consumer ethnocentrism, the preference for domestic products over foreign ones, as a significant factor influencing consumer behavior in both emerging and developed markets. Studies suggest that ethnocentric tendencies are more pronounced in emerging markets, driven by factors like national pride, perceived superiority, and familiarity with local products. This preference for domestic products is often linked to domestic country bias, the general inclination toward goods and brands from one's own country. However, this bias is not absolute and is moderated by product quality perceptions and the perceived capabilities of developing nations to produce high‐quality goods. In contrast, consumers in developed markets, exposed to international brands, may display a greater openness to foreign products, often driven by psychological factors like self‐expression and the symbolic value associated with these brands. Understanding these nuances of consumer ethnocentrism and domestic country bias is crucial for businesses to effectively tailor their marketing strategies and cater to diverse consumer preferences in different markets.
Optimizing insect repellence in open sun drying of fish through the combined influence of salt, turmeric, pepper and the bacteriocin nisin under tropical conditions
Authors: Nusrat Nadia , Reza Md. Shaheed , Hasan Muhammad Mehedi , Kamal Md. 
Published: September 2024

AbstractBackgroundSun drying of fish in open air is an age‐old traditional practice in Asia and some other parts of the world. This study aims to suggest optimal field doses of turmeric, pepper, salt and the bacteriocin nisin (food additive, E234) for open‐sun‐dried silver jewfish (Johnius argentatus) under a tropical environment. Investigations were carried out on the blowfly infestation, proximate composition, water reconstitution properties and organoleptic and microbial quality of open‐air‐dried fish samples.ResultsA direct relationship between moisture reduction and drying period was observed with salt‐treated samples demonstrating accelerated moisture reduction, reaching as low as 14.1% after 34 h. Turmeric and pepper treatments provided some protection against weight loss but ultimately extended the drying time to 38 h. Botanical pesticides like turmeric or pepper exhibited significant efficacy against blowfly adult and larval infestation with similar efficacy observed in 15% and 25% salt‐treated samples. Proximate composition analysis revealed that salt‐treated samples had lower moisture ranging from 14.1% to 16.0% but higher protein of 58.2%–62.1%, while the lipid and ash content did not vary significantly (p > 0.05). The water reconstitution properties of salt‐treated samples exhibited superior rehydration rates, with the highest in nisin (Niseen S) + 15% salt‐treated samples at 60°C, while organoleptic evaluations revealed salt‐treated samples to possess favourable attributes with minimal insect infestation and broken pieces. Finally, microbial analysis demonstrated the lowest aerobic plate count in dried fish samples treated with nisin (Niseen S) alone or in combination with 15% salt and/or 3% turmeric ranging from 3.97 ± 0.20 to 4.33 ± 0.07 log cfu/g.ConclusionIt is concluded that 200 ppm nisin (Niseen S)‐treated samples in combination with 3% turmeric and/or 15% salt are a viable option for producing high‐quality dried fish in traditional open‐air sun‐drying practices.
Species selection for automatic chemical kinetic mechanism generation
Authors: Johnson Matthew S. , Pang Hao‐Wei , Liu Mengjie , Green William H. 
Published: September 2024

AbstractMany important chemical kinetic systems require detailed chemical kinetic models to resolve. These detailed kinetic models can involve thousands of species and hundreds of thousands of chemical reactions, making them difficult to construct by hand. Modern automatic mechanism generation algorithms can mostly be divided into two classes: rule and rate based. Rule‐based generators choose species based on user defined constraints on species and reaction classes. Rate‐based generators generate a much larger set of potentially important species and reactions and then choose which ones to add based on running simulations of species and reactions deemed important and calculating the flux to potentially important species. In principle, the latter is preferable, as it requires the user to make far fewer assumptions about what is important in the system. However, while the effectiveness of the rate‐based approach has been demonstrated in a wide variety of systems, it has also been demonstrated to have difficulty picking up important low‐flux chemistries. Here we present a discussion of the challenges associated with rate‐based mechanism generation and new algorithms that are able to efficiently mitigate these challenges improving species selection during mechanism generation in a set of case studies.
All Inorganic Scintillating Fiber for Thermal Neutron Detection
Authors: Zhu Hongliang , Lv Shichao , Hou Dianhao , Li Xueliang , Zhang Feng , Jiang Tianzhi , Yang Zhenlei , Li Jin , Zhou Shifeng , Li Yulan 
Published: September 2024

AbstractThermal neutron detection with scintillating fibers has excellent scientific and technological potential for remote and spatially resolved detection. However, most fibers are polymers, and developing all‐inorganic scintillating fibers remains a significant challenge. Herein, all‐inorganic scintillating fibers and prototype neutron detection devices are successfully constructed for neutron detection. The scintillating fibers with a perfect waveguide configuration and tunable size have been fabricated through the melt‐in‐tube method. The interactions between the thermal neutron and scintillating fiber have been theoretically analyzed. The dependence of the neutron absorption ability on the core diameter, cladding thickness, and 6Li abundance has been investigated. Guided by the above experimental and theoretical results, the configuration of the scintillating fiber and the corresponding neutron detection prototype device has been built. Its practical application for neutron detection has been demonstrated, and importantly, the single thermal neutron event can be successfully monitored. The device shows great promise for neutron detection applications in special scenarios such as tiny space and electromagnetic interference environments.
Amyloid Proteins Adhesive for Slippery Liquid‐Infused Porous Surfaces
Authors: Feng Na , Miao Shuting , Guo Xin , Yang Ziyi , Yan Luke , Yang Peng , Kong Jia 
Published: September 2024

AbstractBiomimetic slippery liquid‐infused porous surfaces (SLIPS) have emerged as a promising solution to solve the limitations of superhydrophobic surfaces, such as inadequate durability in corrosion protection and a propensity for frosting. However, the challenge of ensuring strong, lasting adhesion on diverse materials to enhance the durability of the lubricant layer remains. The research addresses this by leveraging amyloid phase‐transitioned lysozyme (PTL) as an adhesive interlayer, conferring stable attachment of SLIPS across a variety of substrates, including metals, inorganics, and polymers. The silica‐textured interface robustly secures the lubricant with a notably low sliding angle of 1.15°. PTL‐mediated adhesion fortifies the silicone oil attachment to the substrate, ensuring the retention of its repellent efficacy amidst mechanical stressors like ultrasonication, water scrubbing, and centrifugation. The integration of robust adhesion, cross‐substrate compatibility, and durability under stress affords the PTL‐modified SLIPS exceptional anti‐fouling, anti‐icing, and anti‐corrosion properties, marking it as a leading solution for advanced protective applications.
Elastomer Particle Monolayers Formed by the Compression of Poly(methyl acrylate) Microparticles at an Air/Water Interface
Authors: Sasaki Yuma , Nishizawa Yuichiro , Watanabe Natsuki , Uchihashi Takayuki , Suzuki Daisuke 
Published: September 2024

AbstractIn the previous study (Green Chem., 2023, 25, 3418), highly stretchable and mechanically tough poly(methyl acrylate) (pMA) microparticle‐based elastomers can be formed by drying a microparticle‐containing aqueous dispersion. This discovery has the potential to overcome the mechanical weakness of industrially produced aqueous latex films. However, in 3D‐arranged particle films, structural complexity, such as the existence of defects, makes it difficult to clearly understand the relationship between the particle film structure and its mechanical properties. In this study, 2D‐ordered pMA particle monolayers at the air/water interface of a Langmuir trough are prepared. Under high compression at the air/water interface, the microparticles contact their neighboring particles, and the resulting monolayers can be successfully transferred onto a solid substrate. The compression of the monolayer films is linked to an increase in the elastic modulus of the monolayer film on the solid substrate as evident from the local Young's modulus mapping using atomic force microscopy. Thus, pMA particle films with different mechanical properties can be created using a Langmuir trough.
Heavy metal in radiation therapy: A simple method to differentiate hip prosthesis materials
Authors: Miéville Frédéric A. , Pitteloud Nicolas , Pisaturo Olivier , Tercier Pierre‐Alain , Lamanna Giorgio , Achard Vérane , Allal Abdelkarim S. 
Published: September 2024

AbstractBackgroundIn recent years, the number of hip replacement patients receiving radiation therapy has steadily increased. In parallel, strategies have been developed to reduce metal artifacts in computed tomography (CT) images and improve the accuracy of dose calculation algorithms. However, in certain situations, knowledge of the type of prosthesis material is required to accurately determine the dose distribution.PurposeThis study aims to identify physical materials in hip prostheses to correctly assign them in the treatment planning system and improve dose calculation accuracy.MethodsWe first verified the validity of the extended CT mass density calibration curve measured on titanium (Ti) and stainless steel (SS) metal inserts of two different diameters. Then using dedicated reference objects of various circular diameters, we developed a method based on interpolation functions to differentiate between Ti and SS material groups. Forty data sets from 18 patients were used to validate our method on two different reconstruction kernels: a standard Br44f and the electron DirectDensity (Sd40f) kernels from Siemens.ResultsHounsfield units (HU) of Ti and SS inserts were found to vary widely depending on insert diameter, CT spectrum, and reconstruction kernels due to cupping artifacts. The largest HU difference (‐79%) was obtained for SS at 70 kV with Br44f when the diameter increased from 8 to 30 mm. Therefore, under these conditions, the extended CT‐density calibration curve is not recommended for heavy metal density determination. Using our interpolation‐based method, we achieved excellent detection (100%) and material differentiation (100%) results for stems in both reconstruction kernels. At CT energies between 110 and 140 kV, the detection and material differentiation rates were 93.3% and 92.9% for the heads and 93.3% and 92.9% for the acetabular cups, respectively, with the Br44f. Similarly, the use of Sd40f resulted in detection and differentiation rates of 94.7% and 100% for the heads and 100% and 95.0% for the acetabular cups, respectively.ConclusionThis method makes it possible to differentiate between hip prosthesis materials and correctly assign them to the Ti or SS group without prior knowledge of the prosthesis type, regardless of the reconstruction kernels. In combination with the Acuros XB (Varian) or Monte Carlo dose algorithms, excellent dosimetric accuracy can be achieved even in the vicinity of hip prostheses. By performing basic measurements, the method can be adapted to other CT units and reconstruction kernels, replacing the use of an extended CT‐density calibration curve.
Competencies for health‐enhancing physical activity are associated with body mass: results of an updated data pooling across 18 samples
Authors: Carl Johannes , Zheng Miaobing , Popp Johanna , Eckert Katharina , Geidl Wolfgang , Blaschke Simon , Schmid Julia , Grüne Eva , Oppermann Leonard , Liphardt Anna‐Maria , Morf Harriet , Weissenfels Anja , Pfeifer Klaus 
Published: September 2024

AbstractObjectiveAlthough previous studies have illuminated associations between body mass and physical activity (PA), there have been scant insights regarding the physical, cognitive, and motivational determinants of PA in relationship to body mass. This study aimed to model courses of competencies for health‐enhancing PA across the spectrum of BMI.MethodsWe used cross‐sectional data of 3670 individuals (mean [SD]: BMI, 25.54 [5.71] kg/m2; age, 46.11 [14.96] years) from a large data pooling with 18 primary samples employing the PA‐related health competence (PAHCO) instrument. ANCOVA determined differences in 10 PAHCO indicators by BMI categories (underweight, normal weight, overweight, and obesity). Covariate‐adjusted multilevel models described the nonlinear courses of the PAHCO indicators across the BMI spectrum.ResultsThe levels of all 10 PAHCO indicators differed significantly among the BMI categories (F ≥ 14.8; p < 0.001). All competencies for health‐enhancing PA could be best described by cubic functions having their maximum around normal weight while regressing with underweight and with increasing grades of obesity (0.02 ≤  ≤ 0.31).ConclusionsThis study adds to associations between BMI and PA levels by specifying individuals' multidimensional requirements for health‐enhancing PA. The present findings call for an integration of physical, motivational, and cognitive factors in practices of PA promotion and sustainable obesity treatment.
Elevated mir‐141 in obesity: Insights into the interplay with sirtuin 1 and non‐alcoholic fatty liver disease
Authors: Dadkhah Nikroo Nikta , Jafarinejad Habib , Yousefi Zeynab , Abdolvahabi Zohreh , Malek Mojtaba , Mortazavi Pejman , Pazouki Abdolreza , Mokhber Somayeh , Nourbakhsh Mitra 
Published: September 2024

AbstractBackgroundChanges in gene expression related to obesity are linked to microRNAs, such as miR‐141, which play a crucial role in metabolic homeostasis. Sirtuin 1 (SIRT1), an enzyme that plays a crucial role in regulating various cellular functions and metabolism, is implicated in obesity and the ensuing non‐alcoholic fatty liver disease (NAFLD). The aim of this research was to evaluate the levels of miR‐141 and its relationship with SIRT1 and NAFLD.MethodsA group of 100 adults (50 with obesity and 50 with normal‐weight) were selected and underwent complete clinical evaluation and anthropometric measurements. Biochemical parameters were assessed in blood serum, and the levels of miR‐141 in plasma were measured by real‐time PCR. The expression of the SIRT1 gene was also evaluated in the peripheral blood mononuclear cells using Real‐time PCR. The ELISA technique was used to determine insulin levels. Liver steatosis was assessed by ultrasound.ResultsThe results showed that levels of miR‐141 were significantly increased in participants with obesity compared with the control group. Conversely, the expression of the SIRT1 gene in individuals with obesity was lower than that in control participants. A strong negative correlation was observed between miR‐141 and SIRT1 and a strong positive association was observed between miR‐141 and metabolic parameters. Furthermore, participants with fatty liver had significantly elevated levels of miR‐141 gene expression and lower expression of SIRT1 gene, compared to those without fatty liver.Conclusionelevated levels of miR‐141 in individuals with obesity might be a contributing factor in the repression of SIRT1 in obesity and its consequences, including NAFLD. Therefore, miR‐141 might serve as a suitable diagnostic and therapeutic target in obesity and NAFLD.
Towards model‐guided feedback control of hydrogels bioprinting
Authors: Urrea‐Quintero Jorge‐Humberto , Wessels Henning , Wick Thomas 
Published: September 2024

AbstractThis contribution addresses the problem of controlling the Degree of Crosslinking (DoC) in printed hydrogels through feedback control as a product quality indicator from a modeling approach. We set up a simulation that resembles co‐axial printing of calcium‐alginate (Ca‐Alg) hydrogel as a case study. A well‐known Ca‐Alg gelation model composed of a set of nonlinear coupled diffusion‐reactions equations is adopted as a high‐fidelity model (HFM). A traditional proportional‐integral (PI) controller is designed based on a reduced‐order state‐space linear model of the gelation process. The linear state‐space model is identified from input‐output data collected from the HFM. We formulate an optimization problem to find optimal PI controller parameters that minimize a closed‐loop performance index. The PI controller is directly applied to the nonlinear diffusion‐reaction model to guide the printing process towards a desired DoC. We show its efficacy via some numerical simulations.