bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative Oncology in Cancer Care
Authors: Lopez Gabriel , Lee Richard T. , Chaoul Alejandro , Garcia M. Kay , Cohen Lorenzo 
Published: May 2017

OverviewIntegrative medicine seeks to merge conventional medicine and complementary therapies in a manner that is comprehensive, personalized, evidence based, and safe. Integrative oncology is the term used to describe the application of integrative medicine to cancer care. The field of integrative oncology is a constantly evolving set of disciplines. This chapter reviews the role of integrative medicine in cancer care with an emphasis on effective communication, an overview of the evidence, integrative‐based resources to guide health care providers and patients, and presents a model of how to effectively incorporate integrative medicine within cancer care. Existing research suggests that the majority of cancer patients desire communication with their physicians about integrative medicine. It is the healthcare professional's responsibility to ask patients about their use of complementary medicines and to provide evidence‐based advice to guide patients in this evolving area. Key findings in the areas of mind‐body practices, massage, and acupuncture are presented. Mind‐body practices help to improve mood, sleep quality, physical functioning, and overall well‐being. Massage is helpful at relieving pain, anxiety, and increasing relaxation. Acupuncture has the greatest evidence to support its use in managing symptoms such as chemotherapy‐induced nausea, vomiting, and pain; initial research suggests benefit in providing relief for radiation‐induced xerostomia and other symptoms. Many authoritative resources now exist to help guide patients' appropriate use of complementary therapies, allowing the medical team to follow evidence‐based guidelines.
Carbonylative Tertiary Amide Synthesis from Aryl Iodides and Tertiary Amines via Oxidant‐Free C−N Bond Cleavage Catalyzed by Palladium(II) Chloride in Polyethylene Glycol/Water
Authors: Mane Rajendra S. , Bhanage Bhalchandra M. 
Published: May 2017

AbstractIn this work, we have described the carbonylative synthesis of amides from aryl iodides and tertiary amines as an aminal source via oxidant‐free C(sp3)−N bond cleavage using in situ formation of palladium(0) nanoparticles from palladium(II) chloride in polyethylene glycol 400/water. Notably, these reactions were performed under base‐free, ligand‐free conditions and do not require any oxidant for the C−N bond cleavage. The developed protocol offers the selective N‐dealkylation of tertiary amines in a polyethylene glycol/water solvent system. Numerous symmetrical and unsymmetrical aliphatic, alicyclic, benzyl, as well as aromatic tertiary amines with aryl iodides were well tolerated and afforded the desired products in good yields. Furthermore, the in situ generation of palladium(0) nanoparticles in the polyethylene glycol 400 was confirmed by TEM, FEG‐SEM, EDS and XRD techniques, which strongly indicate that the palladium nanoparticles are highly active species and the reaction proceeds through the classical palladium(0)/palladium(II) pathway. Additionally, the syntheses can be easily scaled up and the catalytic system can be recycled up to five times without loss of its catalytic activity and selectivity.magnified image
Ein Organoruthenium‐Tumortherapeutikum mit unerwartet hoher Selektivität für Plectin
Authors: Meier Samuel M. , Kreutz Dominique , Winter Lilli , Klose Matthias H. M. , Cseh Klaudia , Weiss Tamara , Bileck Andrea , Alte Beatrix , Mader Johanna C. , Jana Samir , Chatterjee Annesha , Bhattacharyya Arindam , Hejl Michaela , Jakupec Michael A. , Heffeter Petra , Berger Walter , Hartinger Christian G. , Keppler Bernhard K. , Wiche Gerhard , Gerner Christopher 
Published: May 2017

AbstractMetallorganische Tumortherapeutika werden durch Ligandenaustausch aktiviert, und es wird gemeinhin angenommen, dass die resultierenden aktivierten Spezies geringe Selektivität für potenzielle zelluläre Ziele zeigen. Durch ein Proteomik‐basiertes Ziel‐Antwort‐Profiling konnte jedoch nachgewiesen werden, dass ein Ruthenium‐Aren‐Pyridincarbothioamid (Plecstatin) eine unerwartet hohe Selektivität für Plectin, ein Strukturprotein und Vernetzer des Zytoskeletts, zeigt, was in einem Plectin‐Knock‐out‐Modell in vitro validiert wurde. In Sphäroidkulturen konnte gezeigt werden, dass die gezielten Wechselwirkungen mit Plectin das Potenzial haben, den invasiven Charakter von Tumoren zu inhibieren. Nach oraler Gabe wirkte Plecstatin‐1 im invasiven B16‐Melanom stärker tumorinhibierend als im CT‐26‐Kolonkarzinom‐Tumormodell.
Insulin – von seiner Entdeckung bis zur industriellen Synthese moderner Insulin‐Analoga
Authors: Moroder Luis , Musiol Hans‐Jürgen 
Published: May 2017

AbstractNach der Entdeckung des Insulins als Medikament gegen Diabetes stand die pharmazeutische Industrie vor der Aufgabe, den Bedarf an Insulin aus tierischen Quellen in möglichst hoher Reinheit und in den benötigten Mengen zu decken. Infolge der Immunreaktion vieler Patienten auf Insulin aus tierischem Pankreasextrakt erlangte der Zugang zu Human‐Insulin höchste Priorität. Nur die enzymkatalysierte Semisynthese am C‐Terminus der Insulin‐B‐Kette ermöglichte eine kommerzielle Herstellung, die jedoch von der Bereitstellung von Schweine‐Insulin abhängig war und zu Versorgungsengpässen führte. Erst die Entwicklung der rDNA‐Technologie ermöglichte die kommerzielle Herstellung von Human‐Insulin über Biosynthese in nahezu unbegrenzten Mengen. Eine erhöhte chemische Diversität war nur durch chemische Synthese erreichbar, vereinfacht durch Fortschritte bei der Festphasenpeptidsynthese und der chemischen Ligation. So wurden Synthesen einkettiger Insulin‐Vorstufen entwickelt, die schnelle Screenings von Insulin‐Analoga mit verbesserten biophysikalischen, biologischen und damit auch neuen therapeutischen Eigenschaften sowie die industrielle Herstellung biosynthetisch nicht zugänglicher Insulin‐Analoga ermöglichten.
Sol–Gel‐Derived Biohybrid Materials Incorporating Long‐Chain DNA Aptamers
Authors: Carrasquilla Carmen , Kapteyn Emily , Li Yingfu , Brennan John D. 
Published: May 2017

AbstractSol–gel‐derived bio/inorganic hybrid materials have been examined for diverse applications, including biosensing, affinity chromatography and drug discovery. However, such materials have mostly been restricted to the interaction between entrapped biorecognition elements and small molecules, owing to the requirement for nanometer‐scale mesopores in the matrix to retain entrapped biorecognition elements. Herein, we report on a new class of macroporous bio/inorganic hybrids, engineered through a high‐throughput materials screening approach, that entrap micron‐sized concatemeric DNA aptamers. We demonstrate that the entrapment of these long‐chain DNA aptamers allows their retention within the macropores of the silica material, so that aptamers can interact with high molecular weight targets such as proteins. Our approach overcomes the major limitation of previous sol–gel‐derived biohybrid materials by enabling molecular recognition for targets beyond small molecules.
Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography
Authors: Örkényi Róbert , Éles János , Faigl Ferenc , Vincze Péter , Prechl Anita , Szakács Zoltán , Kóti János , Greiner István 
Published: May 2017

AbstractContinuous‐flow multistep synthesis is combined with quasi‐continuous final‐product purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4‐difluoronitrobenzene with morpholine followed by a heterogeneous catalytic hydrogenation, the desired monosubstituted product can be continuously separated from the co‐ and by‐products in a purity of over 99 % by coupling a flow reactor sequence to a multiple dual‐mode (MDM) centrifugal partition chromatography (CPC) device. This purification technique has many advantages over HPLC, such as higher resolution and no need for column replacement or silica recycling, and it does not suffer from irreversible adsorption.
CsPbBr3 QD/AlOx Inorganic Nanocomposites with Exceptional Stability in Water, Light, and Heat
Authors: Loiudice Anna , Saris Seryio , Oveisi Emad , Alexander Duncan T. L. , Buonsanti Raffaella 
Published: May 2017

AbstractHerein, the assembly of CsPbBr3 QD/AlOx inorganic nanocomposites, by using atomic layer deposition (ALD) for the growth of the amorphous alumina matrix (AlOx), is described as a novel protection scheme for such QDs. The nucleation and growth of AlOx on the QD surface was thoroughly investigated by miscellaneous techniques, which highlighted the importance of the interaction between the ALD precursors and the QD surface to uniformly coat the QDs while preserving the optoelectronic properties. These nanocomposites show exceptional stability towards exposure to air (for at least 45 days), irradiation under simulated solar spectrum conditions (for at least 8 h), and heat (up to 200 °C in air), and finally upon immersion in water. This method was extended to the assembly of CsPbBrxI3−x QD/AlOx and CsPbI3 QD/AlOx nanocomposites, which were more stable than the pristine QD films.
‘Carrots for Corporate Sustainability’: Impacts of Incentive Inclusiveness and Variety on Environmental Performance
Authors: Dahlmann Frederik , Branicki Layla , Brammer Stephen 
Published: May 2017

AbstractIn this paper we explore the role that managerial incentives play in improving corporate environmental performance, finding that greater inclusiveness of incentive beneficiaries and greater variety of incentive types are important factors in firms' incentive schemes. Drawing on a large dataset of multinational enterprises, our results suggest that including more beneficiaries from different levels within the corporate hierarchy and offering both monetary and non‐monetary rewards are generally more likely to lead to reductions in corporate greenhouse gas emissions. Developing two principles of incentive design, inclusiveness and variety, and the conceptualization of patterns of these in organizations as configurations of incentives, our research contributes substantially to normative advice regarding the relative effectiveness of alternative systems of environmental incentives. Such an understanding of the potential of incentives is critical to informing how firms address complex problems such as sustainability in the context of increasingly extended organizational hierarchies and designs. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Alkynyl N‐Nosylhydrazones: Easy Decomposition to Alknynl Diazomethanes and Application in Allene Synthesis
Authors: Yang Yang , Liu Zhaohong , Porta Alessio , Zanoni Giuseppe , Bi Xihe 
Published: May 2017

AbstractThe decomposition of N‐tosylhydrazones is a safe and convenient method for the generation of donor carbenes. However, alkynyl carbenes cannot be isolated by this route because they readily undergo intramolecular cyclization to pyrazoles as soon as formed from alkynyl N‐tosylhydrazones. Here, the use of alkynyl N‐nosylhydrazones for the in situ generation of alkynyl carbenes and their coupling reaction with boronic acids under metal‐free conditions is reported, giving rise to a wide array of di‐ and trisubstituted allenes. Preliminary mechanistic investigations demonstrated that γ‐protodeboration of propargyl boric acid was responsible for the initial allene formation. This methodology based on the nosyl group allows for novel transformations that involve an alkynylcarbene transient species.
Metal‐Dependent Strengthening and Weakening of M−H and M−C Bonds by an Oxo Ligand: Thermal Gas‐Phase Activation of Methane by [OMH]+ and [MH]+ (M=Mo, Ti)
Authors: Firouzbakht Marjan , Zhou Shaodong , González‐Navarrete Patricio , Schlangen Maria , Kaupp Martin , Schwarz Helmut 
Published: May 2017

AbstractThe thermal gas‐phase reactions of methane with [OMoH]+ and [MoH]+ were investigated by using electrospray‐ionization mass spectrometry (ESI‐MS) complemented by quantum‐chemical calculations. In contrast to the inertness of [MoH]+ towards methane, [OMoH]+ activates the C−H bond to form the ionic product [OMo(CH3)]+ concomitantly with the liberation of H2. The origin of the varying reactivities is traced back to a different influence of the oxo ligand on the Mo−C and Mo−H bonds. While the presence of this ligand weakens both the Ti−H and the Ti−CH3 bonds, both the Mo−H and Mo−CH3 bonds are strengthened. The more pronounced strengthening of the Mo−CH3 bond compared to the Mo−H bond favors the exothermicity of the reaction of [OMoH]+ with CH4.
Self‐Assembly of Di‐N‐Heterocyclic Carbene‐Gold‐Adorned Corannulenes on C60
Authors: Mejuto Carmen , Escobar Luis , Guisado‐Barrios Gregorio , Ballester Pablo , Gusev Dmitry , Peris Eduardo 
Published: May 2017

AbstractThe deprotonation of a corannulene‐based bisazolium salt allowed the preparation of a corannulene‐based NHC di‐AuI complex. The prepared di‐AuI‐complex was tested in the recognition of fullerene‐C60, demonstrating good binding affinity in toluene solution, and producing a host–guest complex with 3:1 stoichiometry, as evidenced by a combination of NMR spectroscopy and ITC titrations. The experimental results are fully supported by DFT calculations. The binding of C60 with the di‐AuI complex in toluene solution is enthalpically and entropically favoured. Remarkably, the entropic term is the dominant parameter in the binding process. The good complementarity that exists between the concave shape of the corannulene‐di‐gold complex and the convex surface of the fullerene, together with the presence of tBu groups and the AuCl fragment are key factors for the measured high affinity between host and guest. The obtained results indicate that fullerene may be acting as a template for the formation of a self‐assembled aggregate involving up to three molecules of the di‐AuI complex.
Tellurite‐Squarate Driven Assembly of a New Family of Nanoscale Clusters Based on (Mo2O2S2)2+
Authors: Purcell Jamie W. , Miras Haralampos N. , Long De‐Liang , Markopoulou Panagiota , Cronin Leroy 
Published: May 2017

AbstractThe preparation and characterization of a new family of four polyoxothiometalate (POTM) clusters are reported, with varying size and complexity, based upon the dimeric [Mo2O2S2(H2O)6]2+ cation with the general formula (NMe4)aKb[(Mo2O2S2)c(TeO4)d(C4O4)e(OH)f] where a,b,c,d,e,f={1,7,14,2,4,10}=1, {Mo28Te2}; {2,26,36,12,10,48}=2, {Mo72Te12}; {0,11,15,3,3,21}=3, {Mo30Te3}; {2,6,12,2,4,16}=4, {Mo24Te2}. The incorporation of tellurite anions allowed the fine tuning of the templating and bridging of the available building blocks, leading to new topologies of increased complexity. The structural diversity of this family of compounds ranges from the highly symmetrical cross‐shaped {Mo24Te2} to the stacked ring structure of {Mo72Te12}, which is the largest tellurium‐containing POTM cluster reported so far. Also a detailed experimental analysis revealed that the pH isolation window extends from acidic to basic values. ESI‐MS analyses not only confirmed the stability of this family in solution but also revealed the stability of the observed virtual building blocks.
Organizational attention and learning under regulatory intervention: Governmental investigation into auto engine quality
Authors: Rhee Mooweon , Kim Young‐Choon 
Published: May 2017

AbstractWe examine the efficacy of government regulation on a firm's product. We draw on the behavioural approach of organization research in order to understand the micromechanisms whereby the regulatory intervention process affects corporate operation. We suggest that while government investigations may limit the improvements in product quality by distracting a firm's attention, this unintended outcome depends on the extent to which the firm engages in a substantive problem‐solving process with the regulator during an investigation process. A longitudinal analysis of the US government's investigation into motor vehicle engine production offers overall support for our argument. The paper concludes with a discussion of the implications that our findings present to learning theory and institutional literature. Copyright © 2017 ASAC. Published by John Wiley & Sons, Ltd.
Characterization of Protonated Model Disaccharides from Tandem Mass Spectrometry and Chemical Dynamics Simulations
Authors: Rossich Molina Estefania , Eizaguirre Ane , Haldys Violette , Urban Dominique , Doisneau Gilles , Bourdreux Yann , Beau Jean‐Marie , Salpin Jean‐Yves , Spezia Riccardo 
Published: May 2017

AbstractThe fragmentation mechanisms of prototypical disaccharides have been studied herein by coupling tandem mass spectrometry (MS) with collisional chemical dynamics simulations. These calculations were performed by explicitly considering the collisions between the protonated sugar and the neutral target gas, which led to an ensemble of trajectories for each system, from which it was possible to obtain reaction products and mechanisms without pre‐imposing them. The β‐aminoethyl and aminopropyl derivatives of cellobiose, maltose, and gentiobiose were studied to observe differences in both the stereochemistry and the location of the glycosidic linkage. Chemical dynamics simulations of MS/MS and MS/MS/MS were used to suggest some primary and secondary fragmentation mechanisms for some experimentally observed product ions. These simulations provided some new insights into the fundamentals of the unimolecular dissociation of protonated sugars under collisional induced dissociation conditions.
The Effect of Temperature on Selectivity in the Oscillatory Mode of the Phenylacetylene Oxidative Carbonylation Reaction
Authors: Parker Julie , Novakovic Katarina 
Published: May 2017

AbstractReaction temperature plays a major role in product selectivity in the oscillatory mode of the palladium‐catalyzed phenylacetylene oxidative carbonylation reaction. At 40 °C, dimethyl (2Z)‐2‐phenyl‐2‐butenedioate is the major product whereas at 0 °C the major product is 5,5‐dimethoxy‐3‐phenyl‐2(5H)‐furanone. The occurrence of oscillations in pH coincides with an increase in the rate of phenylacetylene consumption and associated product formation. Experiments were performed isothermally in a reaction calorimeter to correlate reactant consumption and product formation with the occurrence of pH oscillations and the heat released by the reaction. An increase in the size of the pH drop in a single oscillation correlates with an increase in energy, indicating that this section of a single oscillation relates to reactant consumption. Based on these observations, a reaction pathway responsible for product formation is provided.
Discontinuity surfaces and microfacies in a storm‐dominated shallow Epeiric Sea, Devonian Cedar Valley Group, Iowa
Authors: Brady Mara , Bowie Christopher 
Published: May 2017

AbstractDiscontinuity surfaces develop in carbonate successions in response to a range of environmental changes and represent an integral part of the stratigraphic record. In Palaeozoic shallow epeiric basins that are typified by extremely slow subsidence and intermittent sedimentation, discontinuity surfaces may represent the majority of the time‐rock record. A depositional and sequence‐stratigraphic model was developed through microfacies analysis and discontinuity surface characterization using three cores in a proximal to distal transect across the Middle to Upper Devonian Iowa Basin. Twelve microfacies are recognized, spanning supratidal to deep subtidal facies tracts. A total of 105 discontinuity surfaces were documented and classified as either submarine omission surfaces, subaerial exposure surfaces or submarine erosional surfaces. Omission surfaces increase in frequency basinward, indicating increased sediment starvation in the offshore direction. Exposure surfaces increase in frequency shoreward, indicating more frequent subaerial exposure in a shallower setting. Erosional surfaces are dominant in the inner and middle ramp and interpreted as the base of storm beds (tempestites); these surfaces are rare in the outer ramp due to its generally deeper setting below storm wave base. Moreover, discontinuity surfaces exhibit systematic groupings stratigraphically (vertically) across the three localities spanning the Devonian carbonate ramp. Zones of either exposure‐dominated, erosion‐dominated or omission‐dominated surfaces were recognized and correlated with their landward or basinward equivalents (along with shifts in major facies belts) and interpreted in a sequence‐stratigraphic context. This study highlights the importance of including a detailed characterization of both depositional facies and non‐depositional discontinuity surfaces in order to better understand the stratigraphic history of a basin. The framework of analysis provided here is particularly useful for marine carbonate strata deposited in epeiric basins, which are especially common in the Palaeozoic and where non‐deposition and erosion occur frequently, but can also be applied to other geological time periods and settings.
Transcriptome predictors of coral survival and growth in a highly variable environment
Authors: Bay Rachael A. , Palumbi Stephen R. 
Published: May 2017

AbstractConcern over rapid environmental shifts associated with climate change has led to a search for molecular markers of environmental tolerance. Climate‐associated gene expression profiles exist for a number of systems, but have rarely been tied to fitness outcomes, especially in nonmodel organisms. We reciprocally transplanted corals between two backreef locations with more and less variable temperature regimes to disentangle effects of recent and native environment on survival and growth. Coral growth over 12 months was largely determined by local environment. Survival, however, was impacted by native environment; corals from the more variable environment had 22% higher survivorship. By contrast, corals native to the less variable environment had more variable survival. This might represent a “selective sieve” where poor survivors are filtered from the more stressful environment. We also find a potential fitness trade‐off—corals with high survival under stressful conditions grew less in the more benign environment. Transcriptome samples taken a year before transplantation were used to examine gene expression patterns that predicted transplant survival and growth. Two separate clusters of coexpressed genes were predictive of survival in the two locations. Genes from these clusters are candidate biomarkers for predicting persistence of corals under future climate change scenarios.