bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of diesel exhaust particles on macrophage polarization
Authors: Labranche N , Khattabi C El , Berkenboom G , Pochet S 
Published: May 2016

Background: Exposure to diesel exhaust particles (DEP) has long been associated with increased cardiovascular morbidity and mortality. The development of DEP toxicity seems to be linked to inflammation in which macrophages play a critical role. Macrophages can be polarized into proinflammatory M1 or anti-inflammatory M2 macrophages. The aim of this study was to identify the role of inflammation in DEP-induced toxicity by assessing the effects of DEP on macrophage polarization. Methods: Monocyte-derived macrophages (Mϕ) were stimulated with interferon γ and lipopolysaccharide or interleukin (IL)-4 to obtain M1 and M2 subtypes, respectively. To test the polarization capacity of DEP, Mϕ cells were exposed to DEP and compared to Mϕ, M1, and M2. We also studied the effects of DEP on already-polarized M1 or M2. The M1 markers assessed were tumor necrosis factor α (TNF-α) and IL-1β, while the M2 markers were the mannose receptor C type 1 (MRC-1) and transglutaminase 2 (TGM2). Results: Western blots revealed a 31 kDa band corresponding to pro-IL-1β, but only in M1-polarized macrophages. In M1, we also observed an upregulation of TNF-α messenger RNA (mRNA) expression. MRC-1 and TGM2 mRNA expression were only significantly enhanced in M2. DEP had no effect on any of the M1/M2 markers assessed. Moreover, DEP were not able to modify the phenotype of already-polarized M1 or M2. Conclusion: Mϕ incubation with DEP did not have any effect on macrophage polarization, at least on the markers assessed in this study, namely, TNF-α/IL-1β for M1, and MRC-1/TGM2 for M2. Hence, these data argue against an important role of inflammation in DEP-induced vascular toxicity.
Solution-Focused Brief Therapy With Substance-Using Individuals
Authors: Kim Johnny S. , Brook Jody , Akin Becci A. 
Published: May 2016

Objective: This study examined the effectiveness of solution-focused brief therapy (SFBT) intervention on substance abuse and trauma-related problems. Methods: A randomized controlled trial design was used to evaluate the effectiveness of SFBT in primary substance use treatment services for child welfare involved parents in outpatient treatment for substance use disorders. Mixed linear models were used to test within- and between-group changes using intent-to-treat analysis ( N = 64). Hedges’s g effect sizes were also calculated to examine magnitude of treatment effects. Results: Both groups decreased on the Addiction Severity Index-Self-Report and the Trauma Symptom Checklist-40. The between group effect sizes were not statistically significant on either measures, thus SFBT produced similar results as the research supported treatments the control group received. Conclusion: Results support the use of SFBT in treating substance use and trauma and provide an alternative approach that is more strengths based and less problem focused.
Quantifying beliefs regarding telehealth: Development of the Whole Systems Demonstrator Service User Technology Acceptability Questionnaire
Authors: Hirani Shashivadan P , Rixon Lorna , Beynon Michelle , Cartwright Martin , Cleanthous Sophie , Selva Abi , Sanders Caroline , Newman Stanton P 
Published: May 2016

Introduction Telehealth (TH) is a potential solution to the increased incidence of chronic illness in an ageing population. The extent to which older people and users with chronic conditions accept and adhere to using assistive technologies is a potential barrier to mainstreaming the service. This study reports the development and validation of the Whole Systems Demonstrator (WSD) Service User Technology Acceptability Questionnaire (SUTAQ). Methods Questionnaires measuring the acceptability of TH, quality of life, well-being and psychological processes were completed by 478 users of TH. The 22 acceptability items were subject to principal components analysis (PCA) to determine sub-scales. Scale scores, relationships between scales and other patient-reported outcome measures (PROMs), and group differences on scales were utilised to check the reliability and validity of the measure. Results PCAs of SUTAQ items produced six TH acceptability scales: enhanced care, increased accessibility, privacy and discomfort, care personnel concerns, kit as substitution and satisfaction. Significant correlations within these beliefs and between these scales and additional PROMs were coherent, and the SUTAQ sub-scales were able to predict those more likely to refuse TH. Discussion The SUTAQ is an instrument that can be used to measure user beliefs about the acceptability of TH, and has the ability to discriminate between groups and predict individual differences in beliefs and behaviour. Measuring acceptability beliefs of TH users can provide valuable information to direct and target provision of services to increase uptake and maintain use of TH.
The prevalence and clinical significance of anemia in patients hospitalized with acute heart failure
Authors: Frigy Attila , Fogarasi Zoltán , Kocsis Ildikó , Máthé Lehel , Nagy Előd 
Published: May 2016

Abstract In a cohort of patients hospitalized with acute heart failure (AHF) the prevalence of anemia and the existence of a correlation between anemia and the severity of the clinical picture were assessed. Methods. 50 consecutive patients (34 men, 16 women, mean age 67.5 years) hospitalized with AHF were enrolled. Statistical analysis was performed using a chi-square test, for studying univariate correlation between anemia and the presence of diverse parameters reflecting the severity and prognosis of AHF (α=0.05). Results. 21 patients (14 men, 7 women, mean age 69.6 years), representing 42%, had anemia (Hb<12 g/dl) at admission. Comparing patients with and without anemia there were no significant differences regarding age, gender, presence of atrial fibrillation (p=0.75), diabetes (p=1), ischemic heart disease (p=0.9), ejection fraction < 35% (p=1), hypotension at admission (p=0.34), tachycardia>100 b/min at admission (p=0.75), creatinine level >1.5mg% (p=0.12), and need of high dose of loop diuretic >80 mg/day (p=0.23). Conclusions. Anemia is a frequent finding in patients hospitalized with AHF. The presence of anemia was not correlated with other factors related to AHF severity and prognosis. This fact suggests its independent role in influencing the clinical picture and prognosis.
Socio-Psychological Mechanisms of Specialty Image Formation During Professional Evolution
Authors: Гусарова  , Gusarova E. 
Published: May 2016

Results of based on attributive theories researches of social and psychological mechanisms and regularities
related to specialty image formation during professional development have been considered in this
paper. Specialty image definition is presented, attributive theoretical model of the specialty image and its
mechanisms of personal, object and environmental attribution is described and justified.
A technique of this research carrying out has been described in the paper too, and results of empirical
research of the specialty image related to persons at professional development’s various stages (pupils of
profile classes, students, specialists working on the chosen specialty) have been also stated in detail. The
specialty image structure with description of attributive classes and their elements has been presented.
Types of attributive mechanisms and their combinations which are inherent in each of the professional
development considered stages are described in this work too. It has been shown which of these mechanisms
are the most effective for formation of an adequate professional picture of the world.
The author has also presented possible directions for optimization of vocational training process with
participation of business and educational institutions for the best adaptation of young personnel in the
professional environment.
Problem of Professional Self-Determination Formation and Person’s Professional Typology Construction
Authors: Колосова  , Kolosova O. 
Published: May 2016

This paper is based on the results of research related to a problem of professional self-determination
formation and person’s professional typology construction, and devoted to how the knowledge of students’
individual-psychological and social-psychological features will allow during training in higher education
institution not only adequately use natural tendencies and abilities, but also to help in formation of activity’s
individual style allowing to compensate a lack of some components development by development of others
ones. As a result this will allow solve effectively the same professional problems by people with various
combination of operational components in person’s structure. Therefore in this case it is appropriately to
focus attention on the typological approach to person’s features similarity studying under the profession
influence, and, taking this approach as a basis, a more flexible studying of this problem is offered, assuming
the possibility for existence of several types in the same professional community. Therefore, there is an
opportunity for dynamic development of person’s qualities in the presence of strongly expressed motivation
to professional activity.
This direction of researches is especially topical in connection with political and social-economical
transformations in society, and introduction of professional standards, demanding essential changes in
training of specialists. Nowadays there is rather serious gap between employers’ requirements in the labor
market, and knowledge and skills which are gained by graduates during the training. The professional
standards regulating requirements to work’s quality and content and being an obligatory element for an
assessment of graduate’s training quality and his readiness for the future professional activity only describe
necessary parameters, without answering a question how these parameters may be created at the youth
choosing the certain profession, taking into account person’s specific features. If the person’s professional
choice is defined by random factors and there is no activity’s individual style formation during the training,
such mistakes will be cost much in the future to both the person and the higher education institution.
Social and International Identity of Students’ Personality in the Globalized World: Vietnamese Students’ Experience
Authors: Куликова  , Kulikova O. 
Published: May 2016

This paper is based on the results of studying in Moscow higher educational institutions Vietnamese students’
depth interview. Research is devoted to how students from other countries build their identification, attracting
their social communications networks. This research results allow understand how foreign students face
and cross cultural distinctions to define new prospects of identity that gives them a chance to perform
special social roles and increase their national and heritage identity. This paper suggests that international
educational programs originators consider cultural diversity, recognizing social and cultural influences as
defining factors in foreign students’ learning and everyday life, to make the curriculum and use pedagogical
methods which give a chance to foreign students to develop self-knowledge, openness and citizenship.
Managerial Conflicts in Management Psychology and Institutional Economics
Authors: Лигновская  , Lignovskaya T. , Ерзнкян  , Yerznkyan Bagrat 
Published: May 2016

The authors proceed from the fact that while teaching the management psychology to students which are
already familiar with the institutional economics foundations, it is useful to give them information enable to
draw parallels between these two academic disciplines that will help the students become more familiar not
only with each of these academic disciplines, but also more vividly present themselves problems emerging in
management. In this paper a comparison of typical cases from the management psychology and institutional
economics is carrying out on the example of managerial conflicts.
Family Instability and Locus of Control in Adolescence
Authors: Peter Frauke H. , Spiess C. Katharina 
Published: May 2016

Abstract
Investigating the impact of family instability is important as more and more children experience different family changes in many industrialized countries. In this paper we examine the dynamics of family structure, looking at the potential effect of yearly maternal partnership transitions on adolescents’ locus of control. We aim at combining research on family instability with research on non-cognitive skill formation. We use rich and nationwide German data to identify the relationship between family instability and adolescent locus of control. Combining entropy balancing with a novel econometric method to assess potential bias from omitted variables, we find that experiencing maternal partnership transitions is negatively associated with adolescents’ belief in self-determination and that internal locus of control is reduced by about a fifth of a standard deviation among those affected, even after conditioning on a large number of covariates. This is particularly true if the transitions take place during “middle childhood.”
Tectonic control on the distribution of onshore mud volcanoes in parts of the Upper Benue Trough, northeastern Nigeria.
Authors: Musa Ojochenemi K. , Kurowska Ewa E. , Schoeneich Krzysztof , Alagbe Solomon A. , Ayok Jeremiah 
Published: May 2016

AbstractOnshore mud volcanoes are rare geological phenomena, which in Nigeria were reported for the first time few years ago in the Upper Benue Trough. In this study a detail geological mapping of the area of mud volcanoes occurrence was carried out, with the primary aim of defining their relationship, if any, to the structural geology there. The systematic field reconnaissance included field observations of the structural features, as well as analysis of the location and distribution of the onshore mud volcanoes, marking their locations on the topographic and geological maps, analysis of the aerial photographs and satellite images. The study area covered the central part of the Upper Benue Trough where the onshore mud volcanoes were found. The study area is the part of a sedimentary basin comprising Cretaceous clastic rocks that have been deformed intensively by a network of faults often embedded in the underlying Precambrian basement. This network of faults underwent a rejuvenation period from the Aptian to the Palaeocene. The most prominent tectonic structure in the study area is the NE – SW trending Kaltungo Fault Zone, however, there are other minor faults with N – S and NW – SE trends. This study shows that the mud volcanoes found in the study area are usually located near or within fault zones, within the outcropping Upper Cretaceous Yolde Formation and Upper Bima Sandstone, both of which were deformed by the Kaltungo faults, as well as by other minor faults.Worldwide, incidences of onshore mud volcano formation are usually attributed to areas of tectonic activity, rapid sedimentation or hydrocarbon occurrence. In this study, the interpretation of the field observations and mapping results, combined with information on the structural evolution of the study area and seismic pattern (very scarce), have led to the conclusion that the location of onshore mud volcanoes in the Upper Benue Trough, being located along the fault zones, is structurally controlled. The close relationship between mud volcano location and the structural framework of the area may be interpreted as one of several possible subsurface geological responses to present tectonic activity.
Customer delight: perception of hotel spa consumers
Authors: Elias-Almeida Anabela , Miranda Francisco Javier , Almeida Paulo 
Published: May 2016

Abstract
Delighted customers are those whose expectations have been exceeded by the service provider. Competitors in the hotel business need to go beyond what is expected in order to satisfy the guest with an unpredictable positive experience. This study was aimed to clarify the significance of customer delight as an antecedent to customer loyalty, in five-star hotel spas in Portugal. To better understand spa consumers’ perception of delight, the development and testing of an integrated model was undertaken by examining the relationship between perceived service quality, customer satisfaction, loyalty and customer delight. The model was tested using surveyed data from 427 spa consumers and validated using partial least squares (PLS) technique. The results indicated that satisfaction had a direct positive effect on customer delight and, consequently, influences the effect of customer delight on customer loyalty.
Modeling of Position-, Tool- and Workpiece-Dependent Milling Machine Dynamics
Authors: Brecher Christian , Fey Marcel , Daniels Matthias 
Published: May 2016

AbstractDepending on the machine design, milling machines can show a significant variation of their dynamic properties with respect to the axes configurations, in particular at high speed spindle rotations and high feedrates. Moreover, the workpiece and the milling tool are critical parts of the machine tool and can have a major effect on the dynamic properties. Certain combinations of milling tool,workpiece, tool engagement, process parameters and axes configurations can come along with undesired forced or self-excited vibrations. So far, planning of milling processes usually does not account for these unwanted vibrations. The focus of this paper is to present a modeling framework, which accounts for the abovementioned influences via simulation. The dynamic properties of various workpieces and tools as well as the dynamic properties for many different axes configurations are stored in databases. Based on these databases, the dynamics of any given machine tool configuration can be simulated efficiently based on a substructure coupling approach and an interpolation strategy.
Second-Order Inference for the Mean of a Variable Missing at Random
Authors: Díaz Iván , Carone Marco , van der Laan Mark J. 
Published: May 2016

Abstract
We present a second-order estimator of the mean of a variable subject to missingness, under the missing at random assumption. The estimator improves upon existing methods by using an approximate second-order expansion of the parameter functional, in addition to the first-order expansion employed by standard doubly robust methods. This results in weaker assumptions about the convergence rates necessary to establish consistency, local efficiency, and asymptotic linearity. The general estimation strategy is developed under the targeted minimum loss-based estimation (TMLE) framework. We present a simulation comparing the sensitivity of the first and second-order estimators to the convergence rate of the initial estimators of the outcome regression and missingness score. In our simulation, the second-order TMLE always had a coverage probability equal or closer to the nominal value 0.95, compared to its first-order counterpart. In the best-case scenario, the proposed second-order TMLE had a coverage probability of 0.86 when the first-order TMLE had a coverage probability of zero. We also present a novel first-order estimator inspired by a second-order expansion of the parameter functional. This estimator only requires one-dimensional smoothing, whereas implementation of the second-order TMLE generally requires kernel smoothing on the covariate space. The first-order estimator proposed is expected to have improved finite sample performance compared to existing first-order estimators. In the best-case scenario of our simulation study, the novel first-order TMLE improved the coverage probability from 0 to 0.90. We provide an illustration of our methods using a publicly available dataset to determine the effect of an anticoagulant on health outcomes of patients undergoing percutaneous coronary intervention. We provide R code implementing the proposed estimator.
The rise of working pensioners: the Swedish case
Authors: Flood Lennart , Islam Nizamul 
Published: May 2016

Abstract
According to the Eurostat the old-age dependency (people aged 65 or above relative to those aged 15- 64) in the EU will rise from 28% in 2010 to 58% in 2060. During the same period total hours works are projected to fall contributing to a low projected economic growth over the next half-century. In this paper we argue that this gloomy picture might be challenged by an increase in the employment rates of older workers. Using Sweden as an illustration we show that the ratio of individuals with income from both pension and market work has increased strongly during the last decade. During the same period economic reforms have been introduced creating economic incentives in order to delay the exit from the labor market. In this paper we demonstrate the importance of these economic reforms in explaining increased working hours. The paper also evaluates the fiscal impact of the increase in the employment rates.
Phenotypic plasticity of wall ultrastructure in the green alga Pediastrum s.l. (Chlorophyta, Sphaeropleales)
Authors: Lenarczyk Joanna , Wołowski Konrad 
Published: May 2016

Abstract
This study examined wall ultrastructure variability in the microscopic green alga Pediastrum s.l. Its value as a diagnostic character is discussed. Field and cultured material of 21 taxa were compared using light and scanning electron microscopy. Nine ultrastructural elements occurring on the surface of Pediastrum are documented with LM and SEM micrographs. The highest number of taxa showed reticulate ornamentation composed of a trigonal mesh and granules situated on its corners. The paper considers the use of wall ultrastructure to reconcile traditional and modern taxonomical systems with regard to Pediastrum varieties, and addresses the phylogenetic relationships between strains representing different varieties.
Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP‐dependent biogenesis pathway
Authors: Sinzel Monika , Tan Tao , Wendling Philipp , Kalbacher Hubert , Özbalci Cagakan , Chelius Xenia , Westermann Benedikt , Brügger Britta , Rapaport Doron , Dimmer Kai Stefan 
Published: May 2016

AbstractMitochondria are separated from the remainder of the eukaryotic cell by the mitochondrial outer membrane (MOM). The MOM plays an important role in different transport processes like lipid trafficking and protein import. In yeast, the ER–mitochondria encounter structure (ERMES) has a central, but poorly defined role in both activities. To understand the functions of the ERMES, we searched for suppressors of the deficiency of one of its components, Mdm10, and identified a novel mitochondrial protein that we named Mdm10 complementing protein 3 (Mcp3). Mcp3 partially rescues a variety of ERMES‐related phenotypes. We further demonstrate that Mcp3 is an integral protein of the MOM that follows a unique import pathway. It is recognized initially by the import receptor Tom70 and then crosses the MOM via the translocase of the outer membrane. Mcp3 is next relayed to the TIM23 translocase at the inner membrane, gets processed by the inner membrane peptidase (IMP) and finally integrates into the MOM. Hence, Mcp3 follows a novel biogenesis route where a MOM protein is processed by a peptidase of the inner membrane.