bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symbolic WCET Computation
Authors: Ballabriga Clément , Forget Julien , Lipari Giuseppe 
Published: December 2017

Parametric Worst-case execution time (WCET) analysis of a sequential program produces a formula that represents the worst-case execution time of the program, where parameters of the formula are user-defined parameters of the program (as loop bounds, values of inputs, or internal variables, etc).
In this article we propose a novel methodology to compute the parametric WCET of a program. Unlike other algorithms in the literature, our method is not based on Integer Linear Programming (ILP). Instead, we follow an approach based on the notion of symbolic computation of WCET formulae. After explaining our methodology and proving its correctness, we present a set of experiments to compare our method against the state of the art. We show that our approach dominates other parametric analyses and produces results that are very close to those produced by non-parametric ILP-based approaches, while keeping very good computing time.
An interview with Prof. Ramesh Jain
Authors: Jain Ramesh , Riegler Michael 
Published: December 2017

Ramesh Jain is an entrepreneur, researcher, and educator. He is a Donald Bren Professor in Information & Computer Sciences at University of California, Irvine. Earlier he has been at Georgia Tech, University of California, San Diego, University of Michigan, and some other universities in many countries. He was educated at Nagpur University (B.E.) and Indian Institute of Technology, Kharagpur (Ph.D.) in India. His current research is in Social Life Networks including EventShop and Objective Self, and Health Intelligence. He has been an active member of professional community serving in various positions and contributing more than 400 research papers and coauthoring several books including text books in Machine Vision and Multimedia Computing. He is a Fellow of AAAI, AAAS, ACM, IEEE, IAPR, and SPIE.
Ramesh co-founded several companies, managed them in initial stages, and then turned them over to professional management. He also advised major companies in multimedia and search technology. He still enjoys the thrill of start-up environment.
His research and entrepreneurial interests have been in computer vision, AI, multimedia, and social computing. He is the founding director of Institute for Future Health at UCI.
Empresas y Derechos Humanos
Authors: Ljubetic Yerko 
Published: December 2017

La actividad económica, tanto pública como privada suele tener un impacto directo sobre las personas y comunidades que se desenvuelven tanto en su entorno como en su interior. Las consecuencias sobre el medio ambiente, la salud, la afectación de los derechos de las comunidades, especialmente indígenas, la vulneración de los derechos fundamentales de sus trabajadores, particularmente a través de la adopción de medidas discriminatorias de distinta naturaleza, son los ejemplos más reiterativos de una realidad cada vez más acuciante. Este articulo plantea desafío de las empresas de revisar sus formas de organización a los efectos de dar debida cuenta de estas responsabilidades.
miR-204-5p and miR-211-5p Contribute to BRAF Inhibitor Resistance in Melanoma
Authors: Díaz-Martínez Marta , Benito-Jardón Lucía , Alonso Lola , Koetz-Ploch Lisa , Hernando Eva , Teixidó Joaquin 
Published: December 2017

Abstract
Melanoma treatment with the BRAF V600E inhibitor vemurafenib provides therapeutic benefits but the common emergence of drug resistance remains a challenge. We generated A375 melanoma cells resistant to vemurafenib with the goal of investigating changes in miRNA expression patterns that might contribute to resistance. Increased expression of miR-204-5p and miR-211-5p occurring in vemurafenib-resistant cells was determined to impact vemurafenib response. Their expression was rapidly affected by vemurafenib treatment through RNA stabilization. Similar effects were elicited by MEK and ERK inhibitors but not AKT or Rac inhibitors. Ectopic expression of both miRNA in drug-naïve human melanoma cells was sufficient to confer vemurafenib resistance and more robust tumor growth in vivo. Conversely, silencing their expression in resistant cells inhibited cell growth. Joint overexpression of miR-204-5p and miR-211-5p durably stimulated Ras and MAPK upregulation after vemurafenib exposure. Overall, our findings show how upregulation of miR-204-5p and miR-211-5p following vemurafenib treatment enables the emergence of resistance, with potential implications for mechanism-based strategies to improve vemurafenib responses.
Significance: Identification of miRNAs that enable resistance to BRAF inhibitors in melanoma suggests a mechanism-based strategy to limit resistance and improve clinical outcomes. Cancer Res; 78(4); 1017–30. ©2017 AACR.
Genomic and Epigenomic Signatures in Ovarian Cancer Associated with Resensitization to Platinum Drugs
Authors: Fang Fang , Cardenas Horacio , Huang Hao , Jiang Guanglong , Perkins Susan M. , Zhang Chi , Keer Harold N. , Liu Yunlong , Nephew Kenneth P. , Matei Daniela 
Published: December 2017

Abstract
DNA methylation aberrations have been implicated in acquired resistance to platinum drugs in ovarian cancer. In this study, we elucidated an epigenetic signature associated with platinum drug resensitization that may offer utility in predicting the outcomes of patients who are coadministered a DNA methyltransferase inhibitor. The ovarian cancer specimens we analyzed were derived from a recent clinical trial that compared the responses of patients with recurrent platinum-resistant ovarian cancer who received carboplatin plus the DNA methyltransferase inhibitor guadecitabine or a standard-of-care chemotherapy regimen selected by the treating physician. Tumor biopsies or malignant ascites were collected from patients before treatment (day 1, cycle 1) or after treatment (after 2 cycles) for epigenomic and transcriptomic profiling using the Infinium HumanMethylation450 BeadChip (HM450). We defined 94 gene promoters that were hypomethylated significantly by guadecitabine, with 1,659 genes differentially expressed in pretreatment versus posttreatment tumors. Pathway analysis revealed that the experimental regimen significantly altered immune reactivation and DNA repair pathways. Progression-free survival correlated with baseline expression levels of 1,155 genes involved in 25 networks. In functional investigations in ovarian cancer cells, engineered upregulation of certain signature genes silenced by promoter methylation (DOK2, miR-193a, and others) restored platinum drug sensitivity. Overall, our findings illuminate how inhibiting DNA methylation can sensitize ovarian cancer cells to platinum drugs, in large part by altering gene expression patterns related to DNA repair and immune activation, with implications for improving the personalized care and survival outcomes of ovarian cancer patients.
Significance: Epigenomic targeting may improve therapeutic outcomes in platinum-resistant and recurrent ovarian cancer in part by effects on DNA repair and antitumor immune responses. Cancer Res; 78(3); 631–44. ©2017 AACR.
Race Disparities in the Contribution of miRNA Isoforms and tRNA-Derived Fragments to Triple-Negative Breast Cancer
Authors: Telonis Aristeidis G. , Rigoutsos Isidore 
Published: December 2017

Abstract
Triple-negative breast cancer (TNBC) is a breast cancer subtype characterized by marked differences between White and Black/African-American women. We performed a systems-level analysis on datasets from The Cancer Genome Atlas to elucidate how the expression patterns of mRNAs are shaped by regulatory noncoding RNAs (ncRNA). Specifically, we studied isomiRs, that is, isoforms of miRNAs, and tRNA-derived fragments (tRF). In normal breast tissue, we observed a marked cohesiveness in both the ncRNA and mRNA layers and the associations between them. This cohesiveness was widely disrupted in TNBC. Many mRNAs become either differentially expressed or differentially wired between normal breast and TNBC in tandem with isomiR or tRF dysregulation. The affected pathways included energy metabolism, cell signaling, and immune responses. Within TNBC, the wiring of the affected pathways with isomiRs and tRFs differed in each race. Multiple isomiRs and tRFs arising from specific miRNA loci (e.g., miR-200c, miR-21, the miR-17/92 cluster, the miR-183/96/182 cluster) and from specific tRNA loci (e.g., the nuclear tRNAGly and tRNALeu, the mitochondrial tRNAVal and tRNAPro) were strongly associated with the observed race disparities in TNBC. We highlight the race-specific aspects of transcriptome wiring by discussing in detail the metastasis-related MAPK and the Wnt/β-catenin signaling pathways, two of the many key pathways that were found differentially wired. In conclusion, by employing a data- and knowledge-driven approach, we comprehensively analyzed the normal and cancer transcriptomes to uncover novel key contributors to the race-based disparities of TNBC.
Significance: This big data-driven study comparing normal and cancer transcriptomes uncovers RNA expression differences between Caucasian and African-American patients with triple-negative breast cancer that might help explain disparities in incidence and aggressive character. Cancer Res; 78(5); 1140–54. ©2017 AACR.
Opposing Actions of Fibroblast and Cardiomyocyte Smad3 Signaling in the Infarcted Myocardium
Authors: Kong Ping , Shinde Arti V. , Su Ya , Russo Ilaria , Chen Bijun , Saxena Amit , Conway Simon J. , Graff Jonathan M. , Frangogiannis Nikolaos G. 
Published: December 2017

Background:
Transforming growth factor–βs regulate a wide range of cellular responses by activating Smad-dependent and Smad-independent cascades. In the infarcted heart, Smad3 signaling is activated in both cardiomyocytes and interstitial cells. We hypothesized that cell-specific actions of Smad3 regulate repair and remodeling in the infarcted myocardium.

Methods:
To dissect cell-specific Smad3 actions in myocardial infarction, we generated mice with Smad3 loss in activated fibroblasts or cardiomyocytes. Cardiac function was assessed after reperfused or nonreperfused infarction using echocardiography. The effects of cell-specific Smad3 loss on the infarcted heart were studied using histological studies, assessment of protein, and gene expression levels. In vitro, we studied Smad-dependent and Smad-independent actions in isolated cardiac fibroblasts.

Results:
Mice with fibroblast-specific Smad3 loss had accentuated adverse remodeling after reperfused infarction and exhibited an increased incidence of late rupture after nonreperfused infarction. The consequences of fibroblast-specific Smad3 loss were not a result of effects on acute infarct size but were associated with unrestrained fibroblast proliferation, impaired scar remodeling, reduced fibroblast-derived collagen synthesis, and perturbed alignment of myofibroblast arrays in the infarct. Polarized light microscopy in Sirius red–stained sections demonstrated that the changes in fibroblast morphology were associated with perturbed organization of the collagenous matrix in the infarcted area. In contrast, α-smooth muscle actin expression by infarct myofibroblasts was not affected by Smad3 loss. Smad3 critically regulated fibroblast function, activating integrin-mediated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase–2 (NOX-2) expression. Smad3 loss in cardiomyocytes attenuated remodeling and dysfunction after infarction. Cardiomyocyte-specific Smad3 loss did not affect acute infarct size but was associated with attenuated cardiomyocyte apoptosis in the remodeling myocardium, accompanied by decreased myocardial NOX-2 levels, reduced nitrosative stress, and lower matrix metalloproteinase–2 expression.

Conclusions:
In healing myocardial infarction, myofibroblast- and cardiomyocyte-specific activation of Smad3 has contrasting functional outcomes that may involve activation of an integrin/reactive oxygen axis.
Prospective Study of Fasting Blood Glucose and Intracerebral Hemorrhagic Risk
Authors: Jin Cheng , Li Guohong , Rexrode Kathryn M. , Gurol Mahmut E. , Yuan Xiaodong , Hui Ying , Ruan Chunyu , Vaidya Anand , Wang Yanxiu , Wu Shouling , Gao Xiang 
Published: December 2017

Background and Purpose—
Although diabetes mellitus is an established independent risk factor for ischemic stroke, the association between fasting blood glucose and intracerebral hemorrhage (ICH) is limited and inconsistent. The objective of the current study was to examine the potential impact of long-term fasting blood glucose concentration on subsequent risk of ICH.

Methods—
This prospective study included 96 110 participants of the Kailuan study, living in Kailuan community, Tangshan city, China, who were free of cardiovascular diseases and cancer at baseline (2006). Fasting blood glucose concentration was measured in 2006, 2008, 2010, and 2012. Updated cumulative average fasting blood glucose concentration was used as primary exposure of the current study. Incident ICH from 2006 to 2015 was confirmed by review of medical records.

Results—
During 817 531 person-years of follow-up, we identified 755 incident ICH cases. The nadir risk of ICH was observed at fasting blood glucose concentration of 5.3 mmol/L. The adjusted hazard ratios and their 95% confidence intervals (CIs) of ICH were 1.59 (95% CI, 1.26–2.02) for diabetes mellitus or fasting blood glucose ≥7.00 mmol/L, 1.31 (95% CI, 1.02–1.69) for impaired fasting blood glucose (fasting blood glucose, 6.10–6.99 mmol/L), 0.98 (95% CI, 0.78–1.22) for fasting blood glucose 5.60 to 6.09 mmol/L, and 2.04 (95% CI, 1.23–3.38) for hypoglycemia (fasting blood glucose, <4.00 mmol/L), comparing with normal fasting blood glucose 4.00 to 5.59 mmol/L. The results persisted after excluding individuals who used hypoglycemic, aspirin, antihypertensive agents, or anticoagulants, and those with intracerebral hemorrhagic cases occurred in the first 2 years of follow-up.

Conclusions—
In this large community-based cohort, low (<4.0 mmol/L) and high (≥6.1 mmol/L) fasting blood glucose concentrations were associated with higher risk of incident ICH, relative to fasting blood glucose concentrations of 4.00 to 6.09 mmol/L.
A Reflection on China’s Economic Reform from the Perspective of Catholic Social Teaching
Authors: Gao Zhe 
Published: December 2017

Abstract
It has been nearly four decades since China initiated its economic reform in 1978. In spite of the fact that this reform has brought unprecedented economic growth to China, it is viewed by many (including myself) as problematic and has recently been caught in a tension between recession and inequity. This article explores the structural flaws of China’s economic reforms in the light of modern Catholic social teaching, with particular reference to the basic theological principles it applies within the political-economic spheres. On the basis of the Catholic understanding of economic liberty, market, government, and equity, this article furnishes a public theological agenda for China’s economic reforms, in order to help resolve the problems they are facing. Meanwhile, based on the same theological standpoint, it also provides a critical assessment of the New Left’s negation of the liberal economy.
The Influence of Inter-Cultural Engagement on the Perceptions of Mendicant Friars in the Thirteenth Century Concerning Islam and Muslims
Authors: Lette Rickie 
Published: December 2017

Abstract
A commonly accepted interpretation of how Christians and Muslims perceived and responded to each other during the medieval period remains elusive. While broad surveys have established the existence of dominant perspectives and trends, smaller-scale studies are revealing that responses could be much more complex and nuanced. This article attempts to negotiate a middle ground to examine the perceptions of Islam and Muslims of three mendicant friars. The study demonstrates that direct encounters with Muslims, and their customs, practices, and beliefs, or active engagement with Greco-Arabic philosophy, or both, provided these three men with new means to rationalise the reality of Islam and its followers, breaking the bonds of traditional ideological responses and enabling them to produce novel and more informed perspectives on both. It indicates the potential impact that inter-cultural engagement may have had on the inter-religious perceptions of mendicant friars in the latter part of the thirteenth century.
Tradition in Transition: Mudejar Art and the Emergence of the Illuminated Sephardic Bible in Christian Toledo
Authors: Shalev-Eyni Sarit 
Published: December 2017

Abstract
From their early beginnings, around 1260, Sephardic Bibles were illuminated with carpet pages bearing vegetal and geometric patterns associated with mudejar art. In the early literature, the Muslim-like decoration of the biblical codices was regarded as a possible indication for the existence of local schools of Hebrew Bible decoration in Al-Andalus before the reconquista, a period from which no example has survived. In more recent literature, this assumption has been rejected, and the choice of mudejar is interpreted as a new and conscious preference. This article seeks to revisit the phenomenon through a fresh analysis of the emergence of the Sephardic illuminated Bible in Christian Toledo. The discussion reveals the importance of this first stage for an understanding of the whole phenomenon. It exposes the special connection between mudejar art and biblical codices and the cultural and social circumstances in which this connection was first crystallized and turned into a local tradition.
Dialogue and Heritage in the Cultural Strategy of unesco
Authors: Spivak Dimitri 
Published: December 2017

Abstract
unesco is a scientific, educational, and cultural branch – or specialized agency, to speak in technical terms – of the United Nations organization, which has for the latest seventy years been instrumental in setting standards, promoting scientific research and societal discussions, and supporting innovations, both nationally and internationally. Intercultural dialogue has invariably served as a focal point of its manifold activities. Tracing back some of the basic issues in the elaboration of intercultural dialogue as well as the most actual trends in its development forms the main objective of the present paper. This account comes from years of experience as head of one of the well-known and respected unesco research and educational chairs: Comparative Studies of Spiritual Traditions, their Specific Cultures and Interreligious Dialogue.1
A new species of Bhatia (asexual ascomycetes) and new records from Brazil
Authors: MONTEIRO JOSIANE SANTANA , CARMO LUANA TEIXEIRA DO , SOTÃO HELEN MARIA PONTES 
Published: December 2017

A new species and new records of asexual ascomycetes from Brazil were documented during field trips in the National Forest of Amapá, Amapá State, in the Amazon Forest biome. Bhatia laevispora sp. nov., collected on decaying leaflets of Astrocaryum murumuru (Arecaceae), is described and illustrated. It differs from the type species by monoblastic conidiogenous cells with percurrent extensions and bigger, smooth conidia with brown to dark brown apical cells, paler central cells and pale brown to subhyaline basal cell. Cirrenalia donnae is a new record for the Neotropical region, and Balaniopsis kirkii and Dictyosporium pandani are new records for the American continent. Taxonomic information including descriptions, geographical distribution, comments and illustrations are provided. The genera Balaniopsis, Bhatia and Cirrenalia constitute new additions to the Brazilian mycobiota. This work expands the geographic range of these species to Brazil
Lightning Prediction for Australia Using Multivariate Analyses of Large-Scale Atmospheric Variables
Authors: Bates Bryson C. , Dowdy Andrew J. , Chandler Richard E. 
Published: December 2017

AbstractLightning is a natural hazard that can lead to the ignition of wildfires, disruption and damage to power and telecommunication infrastructures, human and livestock injuries and fatalities, and disruption to airport activities. This paper examines the ability of six statistical and machine-learning classification techniques to distinguish between nonlightning and lightning days at the coarse spatial and temporal scales of current general circulation models and reanalyses. The classification techniques considered were 1) a combination of principal component analysis and logistic regression, 2) classification and regression trees, 3) random forests, 4) linear discriminant analysis, 5) quadratic discriminant analysis, and 6) logistic regression. Lightning-flash counts at six locations across Australia for 2004–13 were used, together with atmospheric variables from the ERA-Interim dataset. Tenfold cross validation was used to evaluate classification performance. It was found that logistic regression was superior to the other classifiers considered and that its prediction skill is much better than using climatological values. The sets of atmospheric variables included in the final logistic-regression models were primarily composed of spatial mean measures of instability and lifting potential, along with atmospheric water content. The memberships of these sets varied among climatic zones.
On Boussinesq Dynamics near the Tropopause
Authors: Asselin Olivier , Bartello Peter , Straub David N. 
Published: December 2017

Abstract
The near-tropopause energy spectrum closely follows a −5/3 power law at mesoscales. Most theories addressing the mesoscale spectrum assume unbalanced dynamics but ignore the tropopause (near which the bulk of the data were collected). Conversely, it has also been proposed that the mesoscale spectrum results from tropopause-induced alterations of geostrophic turbulence. This paper seeks to reconcile these a priori mutually exclusive theories by presenting simulations that permit both unbalanced motion and tropopause-induced effects. The model integrates the nonhydrostatic Boussinesq equations in the presence of a rapidly varying background stratification profile (an idealized tropopause). Decaying turbulence simulations were performed over a wide range of Rossby numbers. In the limit of weak flow (U ≲ 1 m s−1), the essential features of the Boussinesq simulations are well captured by a quasigeostrophic version of the model: secondary roll-ups of filaments and shallow spectral slopes are observed near the tropopause but not elsewhere. However, these tropopause-induced effects rapidly disappear with increasing flow strength. For flow strengths more typical of the tropopause (U ~ 10 m s−1), the spectrum develops a shallow, near −5/3 tail associated with fast-time-scale, unbalanced motion. In contrast to weak flows, this spectral shallowing is evident at any altitude and regardless of the presence of a tropopause. Diagnostics of the fast component of motion reveal significant inertia–gravity wave activity at large horizontal scales (where the balanced flow dominates). However, no evidence points to such activity in the shallow range. That is, the mesoscale of the model is dominated by unbalanced turbulence, not waves. Implications and limitations of these findings are discussed.