bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring influential factors in selecting halal pharmaceuticals among students (study case IAI Tazkia & University Ibnu Khaldun in Bogor)
Authors: Suriedi Muhammad Ridho Al Fathan , Priantina Anita 
Published: September 2024

Users of halal-certified medicines involve individuals, groups, and organizations; individual actors cannot be separated from students. Several factors influence students who use halal-certified medicines, including attitudes, subjective norms, and purchase intentions. These factors are motivated by the desires and needs of students. This study investigates the impact of knowledge, attitudes, and subjective norms on the purchase intention of halal-certified medicines. The research explores the factors influencing the intention to purchase halal-certified over-the-counter medicines among students at IAI Tazkia and Ibn Khaldun University in Bogor. Data collection primarily comprises primary data. The primary data utilized in this study were gathered by distributing questionnaires to 215 student respondents. This research uses a qualitative methodology and is analyzed using Structural Equation Modeling (SEM) with the help of SmartPLS 3 software with 215 respondents. The results showed that the attitude variables and subjective norms were significantly affected. On the other hand, the knowledge variable was found to have a low influence on the purchase intention of halal medicines among Muslim students, indicating that other factors may play a more significant role in their purchase decisions.

Keywords: Attitude, Halal medicine, Purchase intention, Subjective norms
Women's experiences of vaginal examinations in labour: a literature review
Authors: Searle Harriet , White Helen 
Published: September 2024

Background/Aims Evidence for vaginal examinations to assess labour progress is inconclusive and indicates some negative psychological impacts for women. Understanding women's perceptions of vaginal examinations is essential to guide future clinical practice. This literature review aimed to explore women's experiences of vaginal examinations in labour. Methods A comprehensive review of four databases was carried out, searching for publications made between 2012 and 2023. Findings were synthesised using thematic analysis. Results Eight relevant papers were included. Four themes emerged: frequency of vaginal examinations, true, informed consent, emotional reactions and rapport building and humanisation. Conclusions Negative experiences were associated with overuse and lack of properly informed consent. Positive experiences linked to continuity in carer. Further research into alternative ways of assessing labour progression to minimise non-clinically indicated vaginal examinations may improve women's labour experience. Implications for practice There is a need for further education for healthcare professionals on ongoing informed consent, appropriate communication, the necessary frequency of vaginal examinations and avoiding desensitisation. Additional training should be well-established in hospitals to minimise exams when not clinically indicated.
The Systemic Inflammatory Response Index as a Novel Diagnostic Indicator for Bell’s Palsy
Authors: Liu Jianhui , Li Guangyu , Wu Rui , Qin Xuan , Pan Shuixiang , Liang Ping , Sun Jingbo 
Published: September 2024

Aims/Background The systemic inflammatory response index (SIRI), an emerging hematological marker of inflammation, has shown promise as a promising biomarker for a variety of inflammatory conditions. This study aims to explore the diagnostic role of SIRI in Bell’s palsy (BP). Methods For this retrospective study, 73 people diagnosed with BP between January 2021 and December 2023 were recruited, along with 73 healthy controls who were age- and sex-matched. The SIRI and other blood inflammatory markers, including the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), were determined for all participants, by enumerating their peripheral blood cell counts. Facial nerve function was assessed upon admission and after one month of treatment using the House-Brackmann Facial Nerve Grading System (H-B). According to this system, patients with an H-B grade of 1–2 are considered recovered, while those with an H-B grade of 3–6 are regarded as not recovered. Results The SIRI (0.94 vs 0.48, p < 0.001), SII (480.3 vs 329.12, p < 0.001), NLR (2.42 vs 1.41, p < 0.001), and PLR (141.05 vs 117.28, p = 0.001) showed a significant increase in the BP group compared to the control group. The receiver operating characteristic (ROC) curve analysis revealed that the area under the curve (AUC) for SIRI was higher than those for SII, NLR, and PLR, respectively. Upon one-month follow-up, significant differences in the values of SIRI, SII, and NLR were observed between the favorable prognosis group and the poor prognosis group (SIRI: 1.07 vs 0.87, p = 0.011; SII: 647.85 vs 422.11, p = 0.005; NLR: 3.31 vs 2.11, p = 0.013). The AUC of ROC curve for SIRI was found to be lower than that of SII but higher than that of NLR. Conclusion The SIRI has the potential to be an important BP diagnostic and prognostic marker.
Involving children and young people in supportive cancer care research: the value of FDS grant funding and charitable partnerships
Authors: Heggie Claudia , Kisby Natalie , Day Peter , Phillips Bob 
Published: September 2024

INTRODUCTION Involvement of children and young people in research has a multitude of benefits for children, researchers and the quality of the research itself. Despite the benefits of involvement, this is not always completed or reported in practice. METHODS This paper looks at the involvement of children and young people during a research study exploring the acceptability of photobiomodulation for mucositis management. It considers the importance of costing involvement into grant funding, and the value of charitable partnerships in conducting research with patient and public involvement. RESULTS Children and young people with experience of cancer, and their parents, were involved at the stages of grant application, research design, data analysis and dissemination. Involvement of families resulted in changes to inclusion criteria, plain language summaries and participant information documents. They provided insight into data analysis, and designed and filmed co-created video outputs to support acceptability of the treatment, dissemination of the research and research involvement of other children. Involvement was supported both practically and financially by charitable partnership with the Candlelighters children’s cancer charity as well as research grant funding from the Royal College of Surgeons of England’s Faculty of Dental Surgery. CONCLUSIONS Child and parent contributors shaped the research project, resulting in changes to the study design, data analysis and co-creation of video resources. Charitable partnership and flexibility of involvement supported diversity in the context of paediatric cancer research. Researchers should consider what they can contribute in return to child contributors and charities who provide support.
Delays to accessing healthcare for older adults with disabilities in Bengaluru, India: views of healthcare providers and older adults
Authors: Patil Divya Sussana , Bailey Ajay , George Sobin , Ashok Lena 
Published: September 2024

Introduction:
A person’s ability to live independently may be limited by physical and cognitive declines associated with ageing, including disabilities that affect mobility and self-care. This study examines the delays to accessing healthcare facilities among older adults who are frail or have disabilities, using the three-delays model.

Methods:
A qualitative study was conducted during March and April 2022 among 21 older adults (aged 60 or above) who were frail or disabled (using assistive devices) in Bengaluru and nine key informants, consisting of geriatricians, physiotherapists, psychologists and NGO workers. Data were analysed using NVivo 12.

Results:
Delays in accessing healthcare for older adults were attributed to multidimensional factors related to the individual (disability; lack of trust in healthcare workers; low/no income), the community and household (neglect/lack of awareness by the family; limited, inaccessible and unaffordable transport modes) and the health system (poor staffing; under-supplied healthcare facilities; waiting times at the hospital). Delays led to complications, hospitalisations and financial burdens for the older adults. The key informant interviews supported these findings.

Conclusion:
This research highlights that it is important to overcome delays in accessing healthcare for older adults to ensure better health and wellbeing among this group. A holistic approach is needed to reach out to individuals, communities and households, and the healthcare system. Providing adequate transport services to hospitals should be planned in conjunction with the health department for timely delivery of care. Providing health insurance for older adults and improving geriatric care would be highly beneficial to improving health outcomes.
Modeling and application of a bidirectional Mach–Zehnder electro-optic modulator with enhanced high-frequency modulation efficiency
Authors: Ma Xuepei , Ou Yiwen , Qian Li , Guo Huiyong , Cheng Chunfu , Zhou Ciming , Lv Hui 
Published: September 2024

We present a simple way to enhance bidirectional broadband modulation in a traveling wave Mach–Zehnder electro-optic modulator (EOM) by removing matched impedance and effecting a reflection of the microwave signal. A model was devised for determining the modulation efficiency (ME) in the presence of microwave reflection, without access to the physical parameters of the EOM. By using the model, the simulated MEs matched well with the measured ones, which verified the correctness of the model and demonstrated that the internal parameters of the modulator could be inferred from the model. Compared with the traditional unidirectional EOM, the measured ME of the bidirectional modulator for the optical signal that counter-propagates with the incident microwave signal was improved by 10 times at least. When the velocities of microwave and optical signals were matched, the MEs at the frequency higher than 3.3 GHz were further improved. Our model was also used to derive the optical interference signal utilizing bidirectional modulation. It was found that the signal intensity was enhanced significantly, and further improved after introducing the velocity match. This work can be expected to open up many microwave photonics applications where bidirectional optical modulation is utilized in novel sensing and metrology.
Optical circuit switched three-stage twisted-folded Clos-network design model guaranteeing admissible blocking probability
Authors: Taniguchi Ryotaro , Inoue Takeru , Anazawa Kazuya , Oki Eiji 
Published: September 2024

Some data center networks have already started to use optical circuit switching (OCS) with potential performance benefits, including high capacity, low latency, and energy efficiency. This paper addresses a switching network design to maximize the network radix, i.e., the number of terminals connected to the network under the condition that a specified number of identical switches with the size N×N and the maximum admissible blocking probability are given. Previous work presented a two-stage twisted and folded Clos network (TF-Clos) with a blocking probability guarantee for OCS, which has a larger network radix than TF-Clos with a strict-sense non-blocking condition. Expanding the number of stages allows for enhancing the network radix. This paper proposes a model designing an OCS three-stage TF-Clos structure with a blocking probability guarantee to increase the network radix compared to the two-stage TF-Clos. We formulate the problem of obtaining the network configuration that maximizes the network radix as an optimization problem. We conduct an algorithm based on an exhaustive search to obtain a feasible solution satisfying the constraints of the optimization problem. This algorithm identifies the structure with the largest network radix in non-increasing order to avoid unnecessary searches. Numerical results show that the proposed model achieves a larger network radix than the two-stage model.
Artificial intelligence-based digital pathology for the detection and quantification of soil-transmitted helminths eggs
Authors: Cure-Bolt Nancy , Perez Fernando , Broadfield Lindsay A. , Levecke Bruno , Hu Peter , Oleynick John , Beltrán María , Ward Peter , Stuyver Lieven 
Published: September 2024

Background
Conventional microscopy of Kato-Katz (KK1.0) thick smears, the primary method for diagnosing soil-transmitted helminth (STH) infections, has limited sensitivity and is error-prone. Artificial intelligence-based digital pathology (AI-DP) may overcome the constraints of traditional microscopy-based diagnostics. This study in Ucayali, a remote Amazonian region of Peru, compares the performance of AI-DP-based Kato-Katz (KK2.0) method to KK1.0 at diagnosing STH infections in school-aged children (SAC).

Methods
In this prospective, non-interventional study, 510 stool samples from SAC (aged 5–14 years) were analyzed using KK1.0, KK2.0, and tube spontaneous sedimentation technique (TSET). KK1.0 and KK2.0 slides were evaluated at 30-minute and 24-hour timepoints for detection of Ascaris lumbricoides, Trichuris trichiura, and hookworms (at 30-minute only). Diagnostic performance was assessed by measuring STH eggs per gram of stool (EPG), sensitivity of methods, and agreement between the methods.

Results
KK2.0 detected more A. lumbricoides positive samples than KK1.0, with detection rates for T. trichiura and hookworms being comparable. At 30-minutes, 37.6%, 23.0%, and 2.6% of the samples tested positive based on KK1.0 for A. lumbricoides, T. trichiura, and hookworms, while this was 49.8%, 24.4%, and 1.9% for KK2.0. At 24-hours, 37.1% and 27.1% of the samples tested positive based on KK1.0 for A. lumbricoides and T. trichiura, while this was 45.8% and 24.1% for KK2.0. Mean EPG between KK2.0 and KK1.0 were not statistically different across STH species and timepoints, except for T. trichiura at 24-hours (higher mean EPG for KK1.0, p = 0.036). When considering infection intensity levels, KK2.0 identified 10% more of the total population as low-infection intensity samples of A. lumbricoides than KK1.0 (p ≤ 0.001, both timepoints) and similar to KK1.0 for T. trichiura and hookworms. Varying agreement existed between KK1.0 and KK2.0 in detecting STH eggs (A. lumbricoides: moderate; T. trichiura: substantial; hookworms: slight). However, these findings should be interpreted carefully as there are certain limitations that may have impacted the results of this study.

Conclusions
This study demonstrates the potential of the AI-DP-based method for STH diagnosis. While similar to KK1.0, the AI-DP-based method outperforms it in certain aspects. These findings underscore the potential of advancing the AI-DP KK2.0 prototype for dependable STH diagnosis and furthering the development of automated digital microscopes in accordance with WHO guidelines for STH diagnosis.
The impact of the exercise on the social mentality of the Chinese people
Authors: Ji Shuyu , Zhang Kaiqi , Xu Ludan , Wang Xiaolin , Dong Delong , Yang Xiannan 
Published: September 2024

Objective
Engaging in exercise not only encompasses its intrinsic attributes but also signifies its social dimensions. It reflects an underlying emotional tone and cumulative value attributed to exercise by individuals, forming a broad, macro-level socio-psychological relationship in alignment with the conceptual definition of societal mentality. The social mentality is an indicator of a nation’s governance capacity and mirrors the overall socio-psychological profile and needs of its citizens. This study, therefore, aims to investigate the influence of exercise, specifically through the lens of sports, on the sociall mentality of the Chinese population, encompassing aspects of social trust and social equity. Additionally, we explore the distinct mechanisms underlying differences in social class, generation disparities, and spatial dimensions. This inquiry aims to contribute to enhancing governance capabilities and societal stability.

Method
Data for this study was sourced from the 2023 China General Social Survey. We selected 20 variables and analyzed a sample of 6,746 individuals. We employed Ordinary Least Squares (OLS) multiple linear regression models to construct our analysis.

Results
The findings indicate that exercise has a positive influence on the social mentality of the Chinese population. A higher frequency of participation in sports correlates with a more advanced level of social mentality development. Notably, significant disparities exist between the macro-level and micro-level impacts of exercise, suggesting ample room for improvement. Social class, generational disparities, and spatial dimensions demonstrate substantial impact, each exhibiting unique characteristics depending on the specific research question. Furthermore, the weightings of social trust orientation and social equity orientation within the societal mentality dimensions exhibit variability and fluctuations.

Conclusion
When exploring the topic of social mentality, it is recommended to separately discuss the various dimensions it encompasses, thus providing a comprehensive, detailed, and precise portrayal of specific issues. To bolster the influence of exercise on the social mentality, as well as to enhance governance capabilities and societal stability, the following recommendations are proposed: (1) In-depth exploration of differences within social strata to optimize the mechanisms through which exercise influences the social mentality; (2) Balancing generational disparities to establish a solid foundation for the influence of exercise on the social mentality; (3) Recognizing spatial dimensions to harness the spatial dynamism of exercise in shaping the social mentality.
LOTUS: Protocol for a double-blind placebo controlled randomized trial of hemp-derived cannabidiol for the treatment of cannabis use disorder
Authors: Bidwell L. Cinnamon , Martin-Willett Renee , Melendez Samantha N. , Rosa Luiza , Giordano Gregory , Hutchison Kent E. , Bryan Angela D. 
Published: September 2024

Background
As cannabis legalization continues to spread across the United States, average Δ9-tetrahydrocannabinol concentrations in recreational products have significantly increased, and no prior study has evaluated effective treatments to reduce cannabis use among high potency cannabis users. Some research has found that the non-intoxicating cannabinoid cannabidiol reduces cannabis use and cannabis use disorder-related symptoms, such as affective disturbance and withdrawal. Results of these studies are promising but limited to synthetic or isolated forms of cannabidiol.

Objective
Conduct a placebo-controlled randomized control trial comparing the effects of hemp-derived cannabidiol on reducing Δ9-tetrahydrocannabinol use in concentrate users with cannabis use disorder.

Methods
Design. Double-blind, three-arm randomized placebo-controlled trial.
Setting. University in the Denver-Boulder, CO, USA area.
Study population. Community members who are heavy, stable cannabis concentrate users that meet criteria for at least moderate cannabis use disorder and are seeking to decrease or stop cannabis use.
Data. Self-report demographics, substance use, and mental health characteristics, blood and urine based biomarkers and anthropometrics.
Outcomes. Affective, physiological, and physical withdrawal symptoms, Δ9-tetrahydrocannabinol use.
Analysis. Three-group ANOVAs and χ2 tests will be used to compare baseline variables between groups. Characteristics that differ between groups will be evaluated as potential covariates in subsequent analyses. A multilevel modeling framework will be used for primary outcome analysis to account for the repeated observations nested within participants over time. Pairwise post-hoc simple effects tests will be conducted to confirm patterns of differences.

Trial registration
ClinicalTrials.gov NCT06107062.
Cost-Effectiveness Analysis of Current Treatment Options for Eosinophilic Esophagitis
Authors: Hiramoto Brent , Muftah Mayssan , Flanagan Ryan , Shah Eric D. , Chan Walter W. 
Published: September 2024

INTRODUCTION:
The management strategies for eosinophilic esophagitis include proton pump inhibitors (PPIs), swallowed topical corticosteroids (tCSs), elimination diets, and the biologic agent dupilumab, although there remains little guidance on the selection of initial treatment. We performed cost-effectiveness analyses to compare these approaches of first-line therapy.

METHODS:
A Markov model was constructed from a payer perspective to evaluate the cost-effectiveness of first-line therapies for eosinophilic esophagitis, including PPI, tCS, and 6-food elimination diet (SFED), with crossover in treatments for primary and secondary nonresponse. The primary outcome was incremental cost-effectiveness ratio at 2 and 5-year time horizons. Secondary analyses included modeling from a societal perspective that also accounted for patient-specific costs, as well as a separate simplified model comparing dupilumab with tCS and PPI.

RESULTS:
In the base-case scenario (5-year time horizon), the average costs were SFED: $15,296.81, PPI: $16,153.77, and tCS: $20,975.33 as initial therapy, with SFED being the dominant strategy (more effective/less costly), while PPI offered the lowest cost on a 2-year time horizon. From a societal perspective, PPI was the dominant initial strategy on both 2 and 5-year time horizons. Among pharmacologic therapies, PPI was the most cost-effective first-line option. Dupilumab was not cost-effective relative to tCS, unless the quarterly cost is reduced from $7,311 to $2,038.50 per price threshold analysis under permissive modeling conditions.

DISCUSSION:
SFED was the most effective/least costly first-line therapy from the payer perspective while PPI was more cost-effective from the societal perspective. PPI is also the most cost-effective pharmacologic strategy. Dupilumab requires substantial cost reductions to be considered cost-effective first-line pharmacotherapy.
RETRACTED : Exploring Imami Shia Perspectives on the Quran in Bihar Al-Anwar by Al-Majlisy as a Reference for Understanding the Quran
Authors: Yusuf Muhammad 
Published: September 2024

This article has been retracted at the request of the Editor-in-Chief. Please see correcting the record https://ejournal.uin-suka.ac.id/ushuluddin/alquran/ethic#correcting Reason: This article contains some duplicate material of a paper that was originally published in Jurnal Penelitian Keislaman, Vol. 7, No. 1, Desember 2010: 1-28 https://www.academia.edu/35877133/TAFSIR_ESOTERIK_AL_MAJLISIY_DALAM_BIH%C3%82R_AL_ANW%C3%82R One of the conditions of submission of a paper for publication is that authors declare explicitly that all of their work is original and has not appeared in a publication elsewhere. We apologize to readers of the journal that this was not detected during the submission process.