bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomes of Aegilops umbellulata provide new insights into unique structural variations and genetic diversity in the U‐genome for wheat improvement
Authors: Singh Jatinder , Gudi Santosh , Maughan Peter J. , Liu Zhaohui , Kolmer James , Wang Meinan , Chen Xianming , Rouse Matthew N. , Lasserre‐Zuber Pauline , Rimbert Héléne , Sehgal Sunish , Fiedler Jason D. , Choulet Frédéric , Acevedo Maricelis , Gupta Rajeev , Gill Upinder 
Published: September 2024

SummaryAegilops umbellulata serve as an important reservoir for novel biotic and abiotic stress tolerance for wheat improvement. However, chromosomal rearrangements and evolutionary trajectory of this species remain to be elucidated. Here, we present a comprehensive investigation into Ae. umbellulata genome by generating a high‐quality near telomere‐to‐telomere genome assembly of PI 554389 and resequencing 20 additional Ae. umbellulata genomes representing diverse geographical and phenotypic variations. Our analysis unveils complex chromosomal rearrangements, most prominently in 4U and 6U chromosomes, delineating a distinct evolutionary trajectory of Ae. umbellulata from wheat and its relatives. Furthermore, our data rectified the erroneous naming of chromosomes 4U and 6U in the past and highlighted multiple major evolutionary events that led to the present‐day U‐genome. Resequencing of diverse Ae. umbellulata accessions revealed high genetic diversity within the species, partitioning into three distinct evolutionary sub‐populations and supported by extensive phenotypic variability in resistance against several races/pathotypes of five major wheat diseases. Disease evaluations indicated the presence of several novel resistance genes in the resequenced lines for future studies. Resequencing also resulted in the identification of six new haplotypes for Lr9, the first resistance gene cloned from Ae. umbellulata. The extensive genomic and phenotypic resources presented in this study will expedite the future genetic exploration of Ae. umbellulata, facilitating efforts aimed at enhancing resiliency and productivity in wheat.
Infantile hemangioma precursor lesions on day of life 1: A Mayo Clinic retrospective case series
Authors: Jing Frank Z. , Villalpando Beija K. , Tollefson Megha M. 
Published: September 2024

AbstractBackgroundInfantile hemangiomas (IHs), the most prevalent vascular tumors in infancy, are generally understood to be absent at birth, appearing in the initial weeks of life during their proliferative stage. While the classic presentation is recognizable, the precursor lesion of IHs may be misinterpreted as other entities, including vascular malformations.MethodsA retrospective, single‐center study was conducted, examining neonates with photographed IH precursor lesions on day of life (DOL) 1 and matured classical IHs. The study spanned from 2017 to 2023.ResultsThe case series is comprised of nine neonates all exhibiting precursor lesions on DOL 1. A comparative display of photographs featuring precursor lesions and classic IH is presented. Further tabulated information for each case includes IH locations, subsequent treatment modalities, and further diagnostic workup if necessary.ConclusionsImproving recognition of precursor lesions increases diagnostic accuracy, decreasing unnecessary workup. This, in turn, allows dermatologists to confidently employ close follow‐up management strategies. Additionally, in cases of extensive involvement, recognition of the precursor lesion allows for expedited investigation for syndromes such as PHACE (posterior fossa malformations, hemangioma, arterial anomalies, coarctation of the aorta/cardiac defects, and eye abnormalities) and LUMBAR (lower body IH, urogential anomalies, ulceration, myelopathy, bony deformities, anorectal malformations, arterial anomalies, and renal anomalies).
Categorial versus naturalized epistemology
Authors: Zangwill Nick 
Published: September 2024

AbstractHow do we know what kinds of things constitute knowledge or justified belief? Naturalized epistemology is committed to denying a priori insight into the kinds of kinds that are and are not knowledge or justification makers. By contrast, it is argued here that knowledge of these matters is a priori knowledge of a special kind. Such knowledge may be called “categorial.” The dialectical give and take between categorial and naturalized epistemology is pursued, before endorsing an argument that breaks the standoff in favor of categorial epistemology. In particular, an argument is given for a certain kind of mathematical skepticism that is entirely a priori. The skeptical argument turns on categorial claims about actuality. Responses are considered before defending a method of categorial dumbfounding in certain circumstances. This yields a positive argument for the categoriality of fundamental epistemic principles. The categorial rationalist conclusions are embraced and some consequences noted.
Dynamic responses of chlorophyll fluorescence parameters to drought across diverse plant families
Authors: Zait Yotam , Shemer Or Emma , Cochavi Amnon 
Published: September 2024

AbstractChlorophyll fluorescence measurement is a quick and efficient tool for plant stress‐level detection. The use of Pulse amplitude modulation (PAM), allows the detection of the plant stress level under field conditions. Over the years, several parameters estimating different parts of the chlorophyll and photosystem response were developed to describe the plant stress level. Despite all fluorescence parameters being based on the same measurements, their relationship remains unclear, and their response to drought stress is significantly influenced by the incoming light intensity. In this study, we use six different annual plants from different families, both C3 and C4 photosynthesis types, to describe the plant response to drought through the fluorescence parameters response (NPQ, Y(NPQ), and qN). To describe the dynamic response to drought, we employed light‐response curves, adapting and fitting an equation for each curve to compare the drought response for each fluorescence parameter. The results demonstrated that the non‐photochemical quenching (NPQ) and the quantum yield of non‐photochemical quenching [Y(NPQ)] maximal values decrease when the PSII functionality (Fv/Fm) is lower than ~0.7. The basal fluorescence level ( and remained unaffected by the stress level and stayed stable across the various plants and stress levels. Our results indicate that the response of different stress parameters follows a distinct order under continuous drought. Consequently, monitoring just one parameter during long‐term stress assessments may result in biased analysis outcomes. Incorporating multiple chlorophyll fluorescence parameters offers a more accurate reflection of the plant's stress level.
The virtue of ignorance: How epistemic agency needs cognitive limitations
Authors: Rancourt Benjamin T. 
Published: September 2024

AbstractThe thesis defended in this article is that epistemology should treat some of our cognitive limitations not as unfortunate defects or external perturbations to be idealized away in theories of epistemic agency, but as necessary underpinnings of good reasoning. We begin with a problem regarding deliberation that calls epistemic agency into question: our reasons in support of belief are never conclusive and never rule out all doubt. Yet we must rule out all doubt to close deliberation; we must close deliberation to form a full belief; and we must form a full belief to have knowledge. The problem with the first step calls the whole into question. The solution (if we seek an alternative to rejecting traditional epistemic agency, including the existence of beliefs) is our limitations: they prevent us from considering all possible doubt, leaving a tractable space of possibilities. When these limitations are virtuous, they contribute to an effective cognitive system. Once we understand the role of our limitations, it will lead us to a deeper understanding of deliberation, belief, epistemic virtue, and epistemic agency. Limitations are as much a part of agency as, for example, logical relations are. Idealizing them away means idealizing away actual agency.
FORM: Anthropology as design
Authors: Coffey Victoria Baskin , Deger Jennifer 
Published: September 2024

AbstractThis essay argues for design as an expression of analytic rigour and ethical commitment. It explores what it might mean to ‘write’ in collaboration with the entities and forces from Country, ancestors, oceans, soil, honeyeaters, sound, wild bores, frogs, fire, ash, sand, trees, and echoes, to colour, code, bitrates, cameras, computers, and archives. Every design decision in ‘Epistemic attunements’ was conceptually‐motivated and informed by an anthropologically‐attuned sensibilty. It was never simply a case of making things look ‘beautiful’. The analytic force of the design propelled our intermedial arguments forward, but also sideways, down through layers, into shifts of sensation and abrupt moments of pause for specific critical effect.
Attunement: Form in motion
Authors: Tsing Anna L. 
Published: September 2024

AbstractTo nurture and protect even small fragments of liveability, we must get to know the lives of others, human and nonhuman. The Anthropocene collates projects of erasure, and we forget that we need companions. What might it take to bring us back into remembrance? I use the word ‘attunement’ in this essay to refer to attempts to get to know, through alignment, how others express themselves in the world. I'm particularly interested in forms of alignment that refuse Cartesian dreams of minds in contact.
The Fences: A webcomic on collective debt and ruination in Paraguay
Authors: Bernardou Enrique , Bueno David , Schuster Caroline E. 
Published: September 2024

AbstractThe Fences: A webcomic on collective debt and ruination in Paraguay is a production of the Australian‐Paraguayan comics studio CómicsClub comprised of anthropologist and writer Caroline E. Schuster and artists Enrique Bernardou and David Bueno. This webcomic began as an anthropological fieldwork study of climate financing ‐ that is, novel financial arrangements that address the emerging weather‐related risks to human communities of global warming, deforestation, and mass extinction. As we enter an era of ‘global weirding’ characterised by strange and extreme weather, insurance companies have welcomed the opportunity to cast themselves as financial ‘first responders,’ offering coverage for drought, floods, bushfires, and other so‐called secondary perils that cost billions of dollars annually in property damage and reconstruction costs. The webcomic tells this story through interactive sequential art. Through branching timelines and ‘what if?’ scenarios, the project recuperates a critical speculative imagination and offers alternatives to financial modes of ‘buying the future.’
Fire's habit: Elemental media and the politics of apprehension
Authors: Fisher Daniel 
Published: September 2024

AbstractThis article weaves together text, photography, and audio recordings drawn from long‐term ethnographic research in northern Australia to ask what fire is becoming as its everyday, urban manifestations are tethered to the diacritics of catastrophic bushfire, on the one hand, and Indigenous expertise and cultural fire, on the other. In exploring both menacing and mundane facets of urban fire in northern Australia, the article and accompanying exegesis offer ways to see and hear fire's capacities spilling beyond these enduring axes of public concern to differently animate and illuminate a city's eco‐acoustic vitality, complexity, and Indigeneity.
City Influence Network: Mining and Analyzing the Influence of Chinese Cities Based on Social Media
Authors: Wang Lihua , Jiang Shengyi 
Published: September 2024

ABSTRACTThere have been very few studies done on measuring the influence of all prefecture‐level cities on a national scale due to the limited availability of public data, challenges in data collection, and insufficient data comprehensiveness. In this paper, we aim to fill this gap by investigating this problem in China. We first collected 692,859 news articles spanning one full year from the WeChat Official Accounts of 339 cities and Taiwan Province, which served as our study area and dataset. Then, we developed a city extractor module to reduce the ambiguity of place names and constructed a city interaction network. Then, we modeled the City Influence Index (CII) and the intensity of its influence. Finally, we proposed an analytical framework that examines the relationship between CII and Gross Domestic Product (GDP), compares it with the Global Cities Index, conducts influence analysis of cities at different levels, and more. The experimental results demonstrate that our analytical framework can effectively measure the influence of cities on a national scale and uncover the implicit relationships between cities. In doing so, our study offers a new perspective for measuring city influence. Code is available at: https://github.com/vczero/CII.
Leukemia cutis as a prominent clinical sign in a dog with acute myeloid leukemia
Authors: Rogato Francesco , Szladovits Balazs , Martineau Henny , Yale Andrew D. , Mitchell Jordan L. , Holmes Emma J. , Gardner Rachel H. , Guillén Alexandra 
Published: September 2024

AbstractAn eight‐year‐old male neutered crossbreed dog presented with erosive and ulcerative cutaneous lesions in the inguinal regions, the medial aspect of both thighs, and the stifles. Hematologic assessment revealed nonregenerative anemia, thrombocytopenia, and high numbers of neoplastic mononuclear cells with a variable degree of maturation. The mononuclear neoplastic cells, with nuclei measuring 10–20 microns in diameter, accounted for 57% of the nucleated blood cells. In addition, the blood contained increased numbers of mature neutrophils and monocytes with atypical morphology. Cytologic examination of the right popliteal lymph node found high numbers of large mononuclear cells with similar morphology to those in the peripheral blood. Flow cytometry of peripheral blood revealed expression by the mononuclear neoplastic cells of the pan‐leukocyte marker CD45 and myeloid markers CD14, MAC387, and myeloperoxidase (MPO). These results confirmed a diagnosis of acute myeloid leukemia (AML). Computed tomography found moderate nodular hepatosplenomegaly and multifocal bi‐cavitary lymphadenopathy. Histopathologic examination of biopsies from the cutaneous lesions identified infiltration of the dermis by intermediate to large neoplastic round cells. Further treatment was declined, and the owners elected euthanasia. Postmortem examination confirmed AML involvement in the bone marrow, peripheral and intracavitary lymph nodes, heart, liver, kidney, and skin. Neoplastic cells in the bone marrow and skin showed positive immunolabeling for ionized calcium‐binding adaptor protein 1 and MPO. To the best of our knowledge, this is the first report of ulcerative cutaneous lesions observed among the presenting clinical signs in a dog with AML and secondary leukemia cutis.
ДИРОФИЛЯРИОЗ В ПРАКТИКЕ ВРАЧА
Authors: Кнаус А.А. , Бигали А.Б. 
Published: September 2024

В настоящее время проблема дирофиляриоза обусловлена широким распространением возбудителя в природной среде и недостаточной проводимой дегельминтизации зараженных животных. Определить реальную степень распространения заболевания среди людей по Республике Казахстан оказалось невозможным в силу отсутствия системы регистрации заболевания. Целью исследования стало изучение проблемы дирофиляриоза у человека и определение лабораторных методов диагностики данного гельминтоза в г. Караганда.
Возбудители инвазии Dirofilaria immitis являются облигатными паразитами для представителей семейств Псовых и Кошачьих. Заболевание передается трансмиссивным путем – через укусы комаров. По мнению большинства исследователей, человек является случайным и терминирующим хозяином для возбудителя, поскольку самки не достигают половой зрелости в организме человека. Однако В.П. Сергиев и его соавторы пришли к выводу, что личинки дирофилярий способны достигать половой зрелости в организме человека, и более того, самцы могут оплодотворять самок даже при небольшом числе паразитов.
Теоретически, диагностика дирофиляриоза у человека возможна путем комплексного анализа клинических данных и лабораторных исследований (иммунограмма, полимеразная цепная реакция, метод иммуноблота, методы иммуноферментного анализа) Однако в практике применяется только макроскопия – изучение морфологических особенностей паразита во время оперативного вмешательства из удаленной ткани при ревизии или случайном разрезе пораженного участка кожи.
Нами проведен анализ диагностики дирофиляриоза в клинико-диагностических лабораториях и ветеринарных клиниках г. Караганды путем изучения перечня предоставляемых услуг и устного опроса персонала. Несмотря на то, что в Караганде успешно развиваются крупные лабораторные центры разного профиля, диагностика дирофиляриоза у человека не входит в услуги ни одной клинико-диагностической лаборатории и только 2 ветеринарные клиники (40%) определяют данного возбудителя.
Отсутствие лабораторной диагностики дирофиляриоза у человека приводит к постановке только клинического диагноза и не ведет к регистрации случаев заболевания, что в свою очередь приводит к отсутствию эпидемиологического надзора за инфекцией и ведет к ее распространению.
Для успешной борьбы с дирофиляриозом в первую очередь необходимо своевременное и специфическое диагностирование возбудителя заболевания. В связи с этим возникает необходимость подготовки специалистов с углубленным изучением дисциплины «Паразитология» для обучающихся по образовательной программе «Биомедицина» и уделить особое внимание заболеванию, вызываемое паразитом Dirofilaria.
Impacts of Material and Machine on the Variation of Additively Manufactured Cooling Channels
Authors: Altland Abbigail Y. , Corbett Thomas M. , Thole Karen A. 
Published: September 2024

Abstract
While additive manufacturing (AM) can reduce component development time and create unique internal cooling designs, the AM process also introduces several sources of variability, such as the selection of machine, material, and print parameters. Because of these sources, wide variations in a part's geometrical accuracy and surface roughness levels can occur, especially for small internal cooling features that are difficult to post-process. This study investigates how the selection of machine and material in the AM process influences variations in surface quality and deviations from the design intent. Two microscale cooling geometries were tested: wavy channels and diamond-shaped pin fins. Test coupons were fabricated with five different additive machines and four materials using process parameters recommended by the manufacturers. The as-built geometry was measured non-destructively with computed tomography scans. To evaluate surface roughness, the coupons were cut open and examined using a laser microscope. Three distinct roughness profiles on the coupon surfaces were captured including upskin, downskin, and channel walls built at 90 deg to the build plate. Results indicated that both material and machine contribute to producing different roughness levels and very different surface morphologies. The roughness levels on the downskin surfaces are significantly greater than on the upskin or sidewall surfaces. Geometric analysis revealed that while the hydraulic diameter of all coupons was well captured, the pin cross section varied considerably. Along with characterizing the coupon surfaces, cooling performance was investigated by experimentally measuring friction factor and heat transfer. The variations in surface morphology as a function of material and machine resulted in heat transfer fluctuating by up to 50% between coupons featuring wavy channels and 26% for coupons with pin fin arrays. Increased arithmetic mean surface roughness led to increased heat transfer and pressure drop; however, a secondary driver in the performance of the wavy channels was found to be the roughness morphology, which could be described using the surface skewness and kurtosis.
Assessment of the Relationship Between Physical Performance and Percentage Change-of-Direction Deficit in Highly Trained Female Football Players
Authors: Roso-Moliner Alberto , Mainer-Pardos Elena , Bishop Chris , Gonzalo-Skok Oliver 
Published: September 2024

Purpose: Different studies indicate that female players in team sports such as soccer tend to have a lower change-of-direction (COD) deficit (CODD) than their male counterparts and that players who performed better in linear and curved sprints tended to have a worse CODD, suggesting that maximum speed does not equate to a faster COD. This study assessed how performance variables related to speed and jumping influence the variability of %CODD among adult highly trained female soccer players. Methods: Fifty-two highly trained female soccer players (age 23.1 [3.25] y; height 163.6 [5.49] cm; weight 59.7 [5.71] kg) participated in this study and performed 180COD, 40-m sprint, countermovement jump, and standing broad jump tests. Results: Significant correlations were found between 180CODL, %CODDR, %CODDL, and between-limbs standing broad jump asymmetry (r = .28–.74). A very large correlation existed between %CODDR and %CODDL (r = .91). Regression analyses indicated a strong inverse relationship between the 10-m sprint time and %CODDR and %CODDL. No predictive models were found for 180COD in either limb. Differences in performance variables such as 180CODR, 180CODL, and asymmetry %CODD were significant between the high- and low-%CODD groups, with moderate to large effect sizes. Conclusion: The present study suggests that specific physical-performance variables, particularly acceleration and unilateral horizontal jumping, are vital to improving COD in highly trained female soccer players, highlighting the need for specific training interventions.
Serum ganciclovir drug exposure in children receiving standard ganciclovir dosing
Authors: Yang Wenyu , Irwin Adam , Weerdenburg Heather , McWhinney Brett , Cole Theresa , Lei Alice , Han Bing , Zhu Xiao , Gwee Amanda 
Published: September 2024

ABSTRACT

Intravenous ganciclovir (GCV) is used for the treatment of cytomegalovirus (CMV) infection in immunocompromised children. Although the therapeutic target for treatment is unclear, studies have shown a serum area under the concentration–time curve (AUC
24h
) ≥40 mg/L·h correlates with effective CMV prevention. This study aimed to externally validate existing GCV population pharmacokinetic (PopPK) models and develop a model if needed and evaluate the serum AUC
24h
achieved with standard GCV dosing and propose an optimized dosing strategy for immunocompromised children. Ganciclovir drug monitoring data from two pediatric hospitals were retrospectively collected, and published pediatric PopPK models were externally validated. The population AUC
24h
with standard GCV dosing (5 mg/kg twice daily) was calculated, and an optimized dosing strategy was determined using Monte Carlo simulations to achieve an AUC
24h
between 40 and 100 mg/L·h. Overall, 161 samples from 23 children with a median (range) age of 9.0 years (0.4–17.0) and weight of 28.2 kg (5.6–73.3) were analyzed. Transferability of published pediatric PopPK models was limited. Thus, a one-compartment model with first-order absorption and elimination with weight and serum creatinine as covariates was developed. The median (5th–95th percentiles) steady state AUC
24h
with standard dosing was 38.3 mg/L·h (24.8–329.2) with 13 children having an AUC
24h
<40 mg/L·h, particularly those aged <4 years (8/13). An optimized simulated GCV dosing regimen, ranging from 2 to 13 mg/kg twice daily for children with normal renal function, achieved 61%–78% probability of target attainment. Standard GCV dosing likely results in inadequate drug exposure in more than half of the children, particularly those aged <4 years. An optimized dosing regimen has been proposed for clinical validation.