bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artesunate-driven autophagy: a shield against liver hypoxia/reoxygenation insult in rats via modulation of GLP1R, the chief metabolic kinase AMPK, mTOR, ULK1, P70S6K, cyclin D1, Akt, and GSK3β
Authors: Ghoneim Mai El-Sayed , El-Abhar Hanan S. , Abdallah Dalaal M. 
Published: October 2024

Abstract
Background
Hepatic hypoxia/reoxygenation (H/R) insult is a critical issue in hepatic transplant and surgeries, profoundly influencing postoperative prognosis. One crucial pathomechanism in this condition is impaired autophagy flux, which disrupts liver homeostasis. Artesunate, an antimalarial drug, has shown potential in providing hepatoprotection against H/R injury; however, whether it can modulate disrupted autophagy to enhance hepatoprotection remains unclear.

Purpose of the study
Accordingly, we delved into the potential mechanism(s) through which artesunate modulates the autophagy process in a hepatic H/R injury model.

Methods and results
Rats were categorized into three groups, viz. sham operated, H/R, and artesunate-treated (50 mg/kg, i.p). Disease regression was evaluated microscopically, and molecular alternations were assessed biochemically using ELISA and western blotting techniques. Mechanistic analysis revealed that artesunate administration at reperfusion time significantly upregulated the gene expression of GLP1R protein expression of p-AMPK, accompanied by a downregulation in those of p-mTOR, and its target molecule p-ULK1, presenting the first trail to initiate autophagy. Additionally, artesunate reduced H/R-induced hepatic upregulated protein expression of p-mTOR/P70S6K cue, and cyclin D1 content, which positively correlated with the mTOR/P70S6K axis. Moreover, artesunate sharply upregulated active p-Akt, which in turn phosphorylated/inactivated GSK3β, a cascade that indirectly promotes autophagy. Consequently, artesunate increased the hepatic beclin-1 and LC3-II to further uphold its autophagic capacity. The hepato-therapeutic effectiveness of artesunate was further evidenced by reduced serum ALT and AST levels, along with diminished hepatic histopathological alterations.

Conclusion
Artesunate protected liver by triggering autophagy partly by modulating the GLP1R/AMPK/mTOR/ULK1, GLP1R/AMPK/mTOR/P70S6K, cyclin D1, and Akt/GSK3β trajectories providing a significant therapeutic potential in managing hepatic H/R insult.
Exploring the optimal plateau durations of tone burst to elicit masseteric vestibular evoked myogenic potentials: a within-subjects study
Authors: Bhagat Sanket , Neupane Anuj Kumar 
Published: October 2024

Abstract
Objective
The purpose of the present study was to explore the effect of plateau duration in eliciting masseter vestibular evoked myogenic potentials (mVEMPs) in healthy individuals with hearing sensitivity ≤ 15dBHL.

Method
A within-subjects design was utilized in the study. Therefore, ipsilateral tone burst evoked mVEMPs were obtained from 30 healthy individuals using the zygomatic montage at 500 Hz tone bursts. Self-monitoring biofeedback was given during the procedure to confirm the tension of the masseter muscle. mVEMPs were recorded across three different plateau duration from 0 to 2 ms with rise/fall time of 2 ms at 95dBnHL. Hence the median and interquartile range were calculated for descriptive analysis of the data followed by non-parametric inferential statistics.

Results
Tone burst evoked mVEMPs were found to be 100% present across all three plateau durations for both ears at 95 dBnHL. P11 and N21 latencies increased with longer plateau durations in both ears. There were no significant differences in P11-N21 peak-to-peak amplitude or interaural amplitude ratio (IAAR) observed across different plateau durations. IAAR was lowest for a 2 ms plateau duration in the 2–2-2 cycle. No significant variations were found across the three plateau durations.

Conclusion
Significant differences in P11 and N21 latencies were observed across the three stimulus cycles, while no significant differences were found for P11N21 amplitude and IAAR. Yet, there was found to have the highest amplitude and lowest IAAR for 2–2-2 cycle than 2–0-2 and 2–1-2, suggesting it to be the optimal stimulus among the three of them.
Parametric study for shear failure of bearing pads due to hurricane-induced wave loadings
Authors: Iqbal Waqas , Head Monique 
Published: October 2024

AbstractThe increasing frequency of extreme weather events, such as hurricanes and rising sea levels due to climate change, presents significant challenges to coastal infrastructure. With 42% of bridges in the United States exceeding 50 years of age, which surpasses their intended service life, there is a pressing need to assess their structural integrity, especially in coastal regions. This study focuses on evaluating the structural performance of bearing pads in coastal bridges under hurricane-induced wave loadings. Utilizing a combination of physics-based models (PBM), nonlinear modal time history analysis, and numerical validation, the research examines the hysteresis response of eight distinct bearing pad configurations. The findings indicate that reinforced circular bearing pads exhibit significantly greater shear displacements compared to plain elastomeric pads, underscoring the critical influence of shape factors on shear response. Fragility functions developed in the study illustrate the probability of shear failure, with reinforced circular pads showing a 28% higher likelihood of exceedance compared to rectangular plain pads. These results highlight the necessity for advanced design methodologies specifically for bearing pads to enhance the resilience of coastal infrastructure against severe hydrodynamic forces induced by hurricanes.
Compression rates of microbial genomes are associated with genome size and base composition
Authors: Bohlin Jon , Pettersson John H.-O. 
Published: October 2024

Abstract
Background
To what degree a string of symbols can be compressed reveals important details about its complexity. For instance, strings that are not compressible are random and carry a low information potential while the opposite is true for highly compressible strings. We explore to what extent microbial genomes are amenable to compression as they vary considerably both with respect to size and base composition. For instance, microbial genome sizes vary from less than 100,000 base pairs in symbionts to more than 10 million in soil-dwellers. Genomic base composition, often summarized as genomic AT or GC content due to the similar frequencies of adenine and thymine on one hand and cytosine and guanine on the other, also vary substantially; the most extreme microbes can have genomes with AT content below 25% or above 85% AT. Base composition determines the frequency of DNA words, consisting of multiple nucleotides or oligonucleotides, and may therefore also influence compressibility. Using 4,713 RefSeq genomes, we examined the association between compressibility, using both a DNA based- (MBGC) and a general purpose (ZPAQ) compression algorithm, and genome size, AT content as well as genomic oligonucleotide usage variance (OUV) using generalized additive models.

Results
We find that genome size (p < 0.001) and OUV (p < 0.001) are both strongly associated with genome redundancy for both type of file compressors. The DNA-based MBGC compressor managed to improve compression with approximately 3% on average with respect to ZPAQ. Moreover, MBGC detected a significant (p < 0.001) compression ratio difference between AT poor and AT rich genomes which was not detected with ZPAQ.

Conclusion
As lack of compressibility is equivalent to randomness, our findings suggest that smaller and AT rich genomes may have accumulated more random mutations on average than larger and AT poor genomes which, in turn, were significantly more redundant. Moreover, we find that OUV is a strong proxy for genome compressibility in microbial genomes. The ZPAQ compressor was found to agree with the MBGC compressor, albeit with a poorer performance, except for the compressibility of AT-rich and AT-poor/GC-rich genomes.
‘Once you've opened that can of worms’: qualitative study to understand why liaison psychiatry staff are not asking about domestic abuse following self-harm
Authors: Knipe Duleeka , Gregory Alison , Dangar Sarah , Woodhouse Tim , Padmanathan Prianka , Kapur Nav , Moran Paul , Derges Jane 
Published: October 2024

Background
Domestic abuse is a significant risk factor for self-harm and suicide. A large proportion of people presenting to healthcare services following self-harm have experienced domestic abuse. In the UK, routine enquiry for domestic abuse is recommended for people who present having self-harmed, but evidence indicates that this is not happening.

Aims
An exploratory qualitative study to explore liaison psychiatry staff experiences of asking about domestic abuse, including the barriers and challenges to asking.

Method
Semi-structured qualitative interviews with active adult liaison psychiatry staff in the UK. Recruitment was via online platforms and professional networks. A reflexive thematic analysis of the narratives was carried out.

Results
Fifteen participants were interviewed across a variety of disciplines (ten nurses, four doctors, one social worker). The generated themes include the following: asking about domestic abuse – the tension between knowing and doing; ‘delving deeper’ and the fear of making things worse; the entanglement of shame, blame and despondency; domestic abuse was different from other clinical problems (mental illness/substance misuse); and biases, myths and misassumptions guiding practice. Participants indicated the need for better training and education, and clear protocols for eliciting and acting on disclosures.

Conclusion
There is a clear need to improve the support offered to victim-survivors of domestic abuse who self-harm and present to healthcare services. National implementation of education and training to better equip liaison psychiatry teams with the skills and knowledge to sensitively support victim-survivors of domestic abuse is required.
Plasma Renin: A Useful Marker for Mineralocorticoid Adjustment in Patients With Primary Adrenal Insufficiency
Authors: Piazzola Cécilia , Dreves Bleunn , Albarel Frédérique , Nakache Jérémie , Morera Julia , Joubert Michaël , Brue Thierry , Reznik Yves , Castinetti Frédéric 
Published: October 2024

Abstract

Context
Renin is a marker of blood volume. There is no consensus on the validity of plasma renin measurement for adjusting mineralocorticoid (MC) substitution in patients with primary adrenal insufficiency (PAI).

Objective
This work aimed to investigate if plasma renin could be used to adjust MC substitution in patients with PAI.

Methods
A total of 150 patients with at least one measurement of plasma renin followed for PAI at 2 tertiary expert centers between 2008 and 2022 were retrospectively included. As supraphysiological hydrocortisone might have additional MC activity, we integrated the individual hydrocortisone dose to obtain the MC equivalent dose (Eq-MC). Renin less than 20 mIU/L was considered oversubstituted, renin between 20 and 60 mIU/L as correctly substituted, and renin over 60 mIU/L as undersubstituted.

Results
The mean dose of fludrocortisone was 82.3 ± 46 μg/day. Plasma renin was abnormal in 56.7% of cases (7 patients oversubstituted and 78 patients undersubstituted). Abnormalities in electrolyte levels were observed in only 12.7% of patients. Plasma renin correlated negatively with sodium (P &lt; .01) and systolic blood pressure (P = .026), and positively with potassium (P &lt; .01). Doses changes in Eq-MC had a statistically significant effect on renin levels (P = .0037), with an increase of MC dose correlating with a decrease in renin level and vice versa; no correlation was observed using electrolytes or blood pressure.

Conclusion
Plasma renin correlates with electrolytes and blood pressure. While dose changes significantly alter renin levels, electrolytes and blood pressure do not, suggesting that renin may provide more information about MC replacement therapy than electrolytes and blood pressure.
Something old, something new: the origins of an unusual renal cell underpinning a beetle water-conserving mechanism
Authors: Beaven Robin , Koyama Takashi , Naseem Muhammad T. , Halberg Kenneth V. , Denholm Barry 
Published: October 2024

ABSTRACT
Tenebrionid beetles have been highly successful in colonising environments where water is scarce, underpinned by their unique osmoregulatory adaptations. These include a cryptonephridial arrangement of their organs, in which part of their renal/Malpighian tubules are bound to the surface of the rectum. Within the cryptonephridial tubules, an unusual cell type, the leptophragmata, plays a key physiological role underpinning water conservation. Nothing was known about the developmental mechanisms or evolution of these unusual renal cells. Here, we investigate mechanisms underpinning leptophragmata development in Tribolium castaneum. We find that leptophragmata express and require the Tiptop transcription factor, similar to secondary renal cells in Drosophila melanogaster, which express Teashirt and Tiptop, despite Drosophila lacking a crypronephridial arrangement. An additional transcription factor, Dachshund, is required to establish leptophragmata identity and to distinguish them from the secondary cells in the non-cryptonephridial region of renal tubule of Tribolium. Dachshund is also expressed in a sub-population of secondary cells in Drosophila. Leptophragmata, which are unique to the beetle lineage, appear to have originated from a specific renal cell type present ancestrally and to be specified by a conserved repertoire of transcription factors.
Near-maximally swimming schoolmaster snapper (Lutjanus apodus) have a greater metabolic capacity, and only a slightly lower thermal tolerance, than when tested at rest
Authors: Nati Julie J. H. , Malorey Peter , Gamperl Anthony K. 
Published: October 2024

ABSTRACT
To assess the relationship among various measures of thermal tolerance and performance suggested for use in fish, we determined the critical thermal maximum (CTmax), critical swimming speed (Ucrit), maximum thermal tolerance while swimming [CTSmax] and realistic aerobic scope (ASR) of juvenile schoolmaster snapper (Lutjanus apodus). Their CTSmax (37.5±0.1°C) was only slightly lower than their CTmax (38.9±0.1°C) and this is probably because their maximum metabolic rate (MMR) and ASR during the former test were ∼42 and 65% higher, respectively. Furthermore, we did not observe a transition to unsteady (i.e. anaerobically fueled) swimming in the CTSmax test as we did in the Ucrit protocol. These data strongly suggest that thermal tolerance tests on fishes whose lifestyle involves schooling or sustained activity should be performed at ecologically relevant swimming speeds. Our results do not support the hypothesis that failure during a CTSmax test is due to a fish's inability to meet its tissue oxygen demands.
The Liquidity Premium of Digital Payment Vehicle
Authors: Chen Zefeng , Jiang Zhengyang 
Published: October 2024

Do digital payment technologies generate liquidity premia like cash and Treasury? We provide an estimate in the context of the world’s largest digital payment platform, Alipay. Our empirical strategy exploits the variation in the timing of the introduction of money market funds that users on this platform can hold and use for digital transactions. We find that, once a fund becomes eligible for these transactions, its size increases by 45 times on average. Through the lens of an equilibrium demand system model, we show that this size increase implies a liquidity premium of 0.8% per annum. This result provides a unique perspective for understanding and calibrating the liquidity premium of digital currencies. This paper was accepted by Will Cong, finance. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.01309 .
Subjectivities and the Space of Possibilities in Youth Programs: Countering Majoritarian Stories as Social Change in the Australian Context
Authors: Keast Samuel P , Sonn Christopher C 
Published: October 2024

The status quo of many not-for-profit organisations is well-intentioned service provision often coupled with an absence of critical understanding sustained by the restricting nature of neoliberal bureaucracy and funding. In this context, programs aimed at assisting young people from marginalised communities can become mired in individualistic thinking that constrains the space of possibilities for young people through depoliticisation and decontextualization of their realities and thus the kinds of subjectivities available to them. The challenge for the evaluation we discuss in this paper was not only to evaluate the outcomes of the program, but to promote community narratives about the realities for young racialized people in Australia that counter majoritarian stories. We conclude that social change begins within the multidirectional relationships and contact zones of the stakeholders, participants and researchers of youth programs. This means, extending the focus beyond generic youth development and moving toward engaging young people in critical social analysis and empowering them as future social change agents in their communities.
Psychometric properties of the Perceived Parental Autonomy Support Scale (P-PASS) in Spanish late-adolescents
Authors: Rodríguez Menéndez Carmen 
Published: October 2024

This study analyzed psychometric characteristics the Spanish version of the Perceived Parental Autonomy Scale (P-PASS), a self-report questionnaire to assess the adolescent’s perception of parental autonomy support. Confirmatory factor analyses demonstrated the hypothesized two-factor structure of the P-PASS, indicating the distinction between parental autonomy support and controlling parenting. Moreover, convergent validity was confirmed by theoretically consistent associations between the P-PASS and others measures of parental psychological control. Results confirmed that parental autonomy support was a different dimension from overprotection and care. The findings from the hierarchical regression demonstrated the contributions of parental autonomy support and parental control to the development self -concept. Effect sizes findings highlight the upper weight of student’s perceived fathers’ behaviors on students’ family, social and physical self-concept.
Optimization of the static volumetric 3D display system based on two-step two-frequency upconversion of Er3+-doped tellurite glass
Authors: Li Wencai , Ji Kang , Zhao Qiang , Deng Yan , Miao Gang , Han Dongcheng , Chen Biao 
Published: October 2024

We demonstrate a high-brightness, high-contrast static volumetric three-dimensional (3D) display based on the two-step, two-frequency upconversion by optimizing the incidence angle and the number of two-dimensional graphical slices of the digital micromirror device (DMD). A homemade cubic volume of tellurite glass (22mm×22mm×22mm) doped with 0.7% erbium ions (Er3+) is used as the display medium. The volumetric pixels (voxels) of 546 nm luminescence are activated by two lasers of 850 nm and 1550 nm, which are meticulously scanned by a DMD of 1280×800 resolution and a galvanometer scanner, respectively. The brightness and contrast of the resulting 3D imagery are investigated by adjusting the incidence angle of the DMD and optimizing the number of two-dimensional graphical slices. Experimentally, the optimal incidence angle of 55.76° and slices of 25 with nearly 26 million voxels are obtained. The resultant image display is remarkably steady, devoid of any flicker, while delivering exceptional luminance and contrast.
Miniaturized optical system of a laser seeker based on a dynamic and static performance co-design
Authors: Wu Di , Zhang Xiao , Li Xiangping , Song Jinlong , Yi Aiqing , Sheng Kuang 
Published: October 2024

The laser semi-active seeker, crucial for miniaturizing guided munitions, offers high precision, anti-jamming, and rapid response. Current research focuses on system response, spot parameters, and angular velocity accuracy. With small-caliber munitions on the rise, further miniaturization and weight reduction are essential. This paper proposes a design for an optical system that balances dynamic imaging quality and miniaturized static structure. Using quadrant detector principles, factors affecting detection performance are analyzed to determine the optimal spot size and imaging range. Based on imaging requirements and the optical properties of a dual-reflector structure, we determine the design parameters of the system to achieve a combination of dynamic and static performance. Evaluations using ZEMAX and MATLAB confirm that the system achieves ±4∘ linear and ±8∘ full fields of view, 0.12% distortion, 4.52 mrad angular accuracy, a 15.72 mm axial length, and has the possibility of actual production. The system is compact, with excellent spot roundness, stability, and uniform energy distribution, providing a reference for future guided weapon research.
Analysis of the association between different domains and intensities of physical activity in adults: An observational and cross-sectional study
Authors: Christofaro Diego G. D. , Tebar William R. , Ferrari Gerson , dos Santos Amanda B. , Sasaki Jeffer E. , Ritti-Dias Raphael M. , Cucato Gabriel G. 
Published: October 2024

Background and objective
To analyze the association between different domains and intensities of physical activity (PA) in adults.

Methods
269 participants were randomly selected in a community-dwelling representative sampling process. The habitual PA practice was assessed in different domains (occupational, sports practice, and leisure time/commuting) using Baecke’s questionnaire and in different intensities (light, moderate, vigorous, and very vigorous) by accelerometry. Linear regression models analyzed the association between variables.

Results
Moderate and moderate-to-vigorous PA was positively associated with the three PA domain scores. Vigorous PA was associated with sports practice and leisure time/commuting PA. Only sports practice was associated with very vigorous-intensity PA (β = 1.32; 95% CI = 0.29; 2.35). Different associations were observed in stratified analyses according to sex and age groups. Men and younger participants showed an association of domain scores with higher intensity PA than their counterparts.

Conclusion
The findings suggest that higher intensities of PA were observed primarily in leisure time/commuting PA and sports practice, and this association varied according to sex and age.