bluuebunny/crossref_metadata_2025_split huggingface dataset:
“On the move, or staying put?” An analysis of intrametropolitan residential mobility and ageing in place
Authors: Atkins Mariana T. 
Published: August 2017

AbstractPopulation ageing and urbanisation are worldwide phenomena that are transforming societies and having profound economic and social effects on cities and countries throughout the world. Ageing is not taking place evenly, and in many developed cities, ageing growth rates are greater in peripheral areas than in the centre. This paper determines how intrametropolitan residential mobility and ageing‐in‐place patterns vary across age categories and geographical scales, explored through a case study of metropolitan Perth, a rapidly growing, low‐density, sprawling city. Using a life course perspective, this study examines Australian residential mobility census data between 2006 and 2011 and disaggregates this into 4 age categories: preretirement (ages 55–64), seniors in active retirement (ages 65–74), mature‐aged seniors (ages 75–84), and older aged seniors (over 85 years). This study adds to the internal migration literature by offering new insights into the age‐specific mobility patterns of older populations within metropolitan areas. The results reveal that the overriding dynamic is one of stability across the metropolitan area with the dominant trend being “ageing in place.” It was found that the likelihood of residential mobility varies by age, and a 2‐peak mobility pattern was identified, with the preretirement and the older aged seniors exhibiting the most mobility. Additionally, although the majority of moves were short distance, younger ages moved farther than did the older aged categories. The study makes empirical and conceptual contributions to our understanding of ageing residential mobility trends within metropolitan areas.
Multi‐system reliability trend analysis model using incomplete data with application to tank maintenance
Authors: Na Il Yong , Chang Woojin 
Published: August 2017

AbstractThis paper focuses on the estimation of power law type reliability trend analysis model given incomplete failure data from multiple homogeneous machines. In many real situations, we encounter data having missing parts especially in the initial recording stage, so‐called left censored data. We provide a method to estimate the failure intensity function of power law process using left censored data from multiple machines. The method consists of two folds: initially estimate parameters via the law of large numbers theory and revise the estimated parameters recursively through the EM algorithm. The validity of our method is confirmed by simulation experiments. We also apply our method to the real‐world case, Korean ARMY tank maintenance data, and show that our proposed method is applicable to practical maintenance planning.
Quantification of six potential unspecific human biomarkers of 1‐vinyl‐2‐pyrrolidone exposure in Sprague‐Dawley rat urine using gas chromatography coupled with triple mass spectrometry
Authors: Bertram J. , Schettgen T. , Kraus T. 
Published: August 2017

RationaleThe monomer 1‐vinyl‐2‐pyrrolidone (VP) is a substance with excellent solvent features. It is used in a wide variety of pharmaceutical, cosmetic, food industrial or technical applications and produced on an industrial scale. Since VP has caused adenocarcinoma of the nasal cavity and liver cell carcinoma in long‐term experiments with rats, a human biomarker would be appreciated for risk assessment.MethodsA sensitive analytical electron ionization gas chromatography/tandem mass spectrometry (GC/MS/MS) method for the determination of six possible biomarkers for VP in urine was established and validated. Two isotope‐labeled internal standards (ISTD) were used for quantification. A simple and easy to use freeze‐drying step was performed prior to derivatization with N‐tert‐butyldimethylsilyl‐N‐methyltrifluoracetamide (MTBSTFA) and following sample extraction for cleanup purposes.ResultsA calibration curve with six calibration standards ranging from 50 μg/L to 2000 μg/L (10‐fold higher for H‐OPAA) in urine was prepared. Validation results were satisfactory with recoveries ranging from 88.2 to 110.2 % with two exceptions for the lowest quality control for two substances without ISTD (126.4 % and 139.3 %). Three of the substances could be identified as VP metabolites in an exposure study with Sprague‐Dawley (SD) rats.ConclusionsA quick and easy to use method has been established for six target molecules investigated for a better understanding of the metabolism of VP. Two of three substances identified as metabolites of VP could serve as a nonspecific human biomarker for VP exposure as shown with an excerpt of an exposure study performed in SD rats.
Cooperative output regulation of heterogeneous multiagent systems based on event‐triggered control with fixed and switching topologies
Authors: Jia Hongwei , Zhao Jun 
Published: August 2017

SummaryThis paper addresses the cooperative output regulation problem of multiagent systems with fixed and switching topologies. Each agent is a heterogeneous linear system, and the output of the exosystem can be available to only a subset of agents. For the agents that can directly access the exosystem, a common observer based on an event‐triggered strategy is constructed to estimate the exogenous signal for feedback control design. For the rest of the agents, estimators based on an event‐triggered mechanism to acquire the estimation value of the exogenous signal are designed under some essential assumptions. A decentralized event‐triggered formulation is considered first by applying a Lyapunov function for a fixed topology. Furthermore, a topology‐dependent triggering condition and the average dwell‐time switching law are deduced simultaneously by using multiple Lyapunov functions for switching topologies. Under communication constraints, we propose observer‐based and estimator‐based feedback controllers to solve the cooperative output regulation problem using available local information among agents. Two examples are finally provided to verify the effectiveness of the proposed theoretical results.
An improved robust model predictive control for linear parameter‐varying input‐output models
Authors: Abbas H. S. , Hanema J. , Tóth R. , Mohammadpour J. , Meskin N. 
Published: August 2017

SummaryThis paper describes a new robust model predictive control (MPC) scheme to control the discrete‐time linear parameter‐varying input‐output models subject to input and output constraints. Closed‐loop asymptotic stability is guaranteed by including a quadratic terminal cost and an ellipsoidal terminal set, which are solved offline, for the underlying online MPC optimization problem. The main attractive feature of the proposed scheme in comparison with previously published results is that all offline computations are now based on the convex optimization problem, which significantly reduces conservatism and computational complexity. Moreover, the proposed scheme can handle a wider class of linear parameter‐varying input‐output models than those considered by previous schemes without increasing the complexity. For an illustration, the predictive control of a continuously stirred tank reactor is provided with the proposed method.
Does Corporate Sustainability Performance Increase Corporate Financial Performance? Focusing on the Information and Communication Technology Industry in Korea
Authors: Jung Seonmin , Nam Changi , Yang Dong‐Hoon , Kim Seongcheol 
Published: August 2017

AbstractCorporate sustainability has increased in importance, because corporations must survive in a social and ecological network as an interdependent going concern. However, from a business perspective, it is an empirical issue whether the firm's corporate sustainability performance is associated with its financial performance. In this paper, based on Ohlson's residual income model, the effect of corporate sustainability performance on financial performance is examined by utilizing the newly developed Korea Sustainability Index as a proxy for corporate sustainability performance. It was found that a firm's corporate sustainability performance is positively associated with its financial performance, and this positive association is more sensitive in the information and communications technology (ICT) industry than in non‐ICT firms. Furthermore, this moderating effect is mainly attributable to the service sector in the ICT industry. These effects are prominent in smaller low‐leveraged firms. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Light‐Induced Contraction/Expansion of 1D Photoswitchable Metallopolymer Monitored at the Solid–Liquid Interface
Authors: Garah Mohamed El , Borré Etienne , Ciesielski Artur , Dianat Arezoo , Gutierrez Rafael , Cuniberti Gianaurelio , Bellemin‐Laponnaz Stéphane , Mauro Matteo , Samorì Paolo 
Published: August 2017

AbstractThe use of a bottom‐up approach to the fabrication of nanopatterned functional surfaces, which are capable to respond to external stimuli, is of great current interest. Herein, the preparation of light‐responsive, linear supramolecular metallopolymers constituted by the ideally infinite repetition of a ditopic ligand bearing an azoaryl moiety and Co(II) coordination nodes is described. The supramolecular polymerization process is followed by optical spectroscopy in dimethylformamide solution. Noteworthy, a submolecularly resolved scanning tunneling microscopy (STM) study of the in situ reversible trans‐to‐cis photoisomerization of a photoswitchable metallopolymer that self‐assembles into 2D crystalline patterns onto a highly oriented pyrolytic graphite surface is achieved for the first time. The STM analysis of the nanopatterned surfaces is corroborated by modeling the physisorbed species onto a graphene slab before and after irradiation by means of density functional theory calculation. Significantly, switching of the monolayers consisting of supramolecular Co(II) metallopolymer bearing trans‐azoaryl units to a novel pattern based on cis isomers can be triggered by UV light and reversed back to the trans conformer by using visible light, thereby restoring the trans‐based supramolecular 2D packing. These findings represent a step forward toward the design and preparation of photoresponsive “smart” surfaces organized with an atomic precision.
The architectural template method: templating architectural knowledge to efficiently conduct quality‐of‐service analyses
Authors: Lehrig Sebastian , Hilbrich Marcus , Becker Steffen 
Published: August 2017

SummarySoftware architects plan the realization of software systems by assessing design decisions on the basis of architectural models. Using these models as input, architectural analyses assess the impact of architects' decisions on quality‐of‐service properties. While the creation of suitable architectural models requires software architects to apply complex architectural knowledge, for example, in the form of established architectural styles and patterns, current architectural analyses lack support for directly reusing such knowledge. This lack points to an unused potential to make the work of software architects more effective and efficient.To use this potential, we introduce the architectural template (AT) method, an engineering method that makes design‐time analyses of quality‐of‐service properties of software systems more efficient. The AT method allows to quantify quality‐of‐service properties on the basis of reusable modeling templates that capture recurring architectural knowledge. Architects just need to customize such templates with system‐specific parts. In a case study, we illustrate the applicability of the AT method in the domains of distributed and cloud computing and its suitability for the quality‐of‐service properties performance, scalability, elasticity, and cost‐efficiency. Copyright © 2017 John Wiley & Sons, Ltd.
A seven-year retrospective analysis of the clinicopathological and mycological manifestations of fungal rhinosinusitis in a single-centre tropical climate hospital
Authors: Goh L C , Shakri E D , Ong H Y , Mustakim S , Shaariyah M M , Ng W S J , Zulkiflee A B 
Published: August 2017

AbstractObjective:To evaluate the clinicopathological and mycological manifestations of fungal rhinosinusitis occurring in the Tengku Ampuan Rahimah Hospital, in Klang, Malaysia, which has a tropical climate.Methods:Records of patients treated from 2009 to 2016 were analysed retrospectively. Data from the records were indexed based on age, gender, clinical presentations, symptom duration, clinical signs and mycological growth.Results:Of 80 samples, 27 (33.75 per cent) had fungal growth. Sixteen patients were classified as having non-invasive fungal rhinosinusitis and 11 as having invasive fungal rhinosinusitis. The commonest clinical presentation was nasal polyposis in non-invasive fungal rhinosinusitis patients (p < 0.05) and ocular symptoms in invasive fungal rhinosinusitis patients (p < 0.05). The commonest organism was aspergillus sp. (p < 0.05) in non-invasive fungal rhinosinusitis and mucorales in invasive fungal rhinosinusitis.Conclusion:There is an almost equal distribution of both invasive and non-invasive fungal rhinosinusitis, as seen in some Asian countries. Invasive fungal rhinosinusitis, while slightly uncommon when compared to non-invasive fungal rhinosinusitis, is potentially life threatening, and may require early and extensive surgical debridement. The clinical presentation of nasal polyposis was often associated with non-invasive fungal rhinosinusitis, whereas ocular symptoms were more likely to be associated with invasive fungal rhinosinusitis.
Alternative splicing discriminates molecular subtypes and has prognostic impact in diffuse large B-cell lymphoma
Authors: Leivonen S-K , Taskinen M , Cervera A , Karjalainen-Lindsberg M-L , Delabie J , Holte H , Lehtonen R , Hautaniemi S , Leppä S 
Published: August 2017

AbstractEffect of alternative splicing (AS) on diffuse large B-cell lymphoma (DLBCL) pathogenesis and survival has not been systematically addressed. Here, we compared differentially expressed genes and exons in association with survival after chemoimmunotherapy, and between germinal center B-cell like (GCB) and activated B-cell like (ABC) DLBCLs. Genome-wide exon array-based screen was performed from samples of 38 clinically high-risk patients who were treated in a Nordic phase II study with dose-dense chemoimmunotherapy and central nervous system prophylaxis. The exon expression profile separated the patients according to molecular subgroups and survival better than the gene expression profile. Pathway analyses revealed enrichment of AS genes in inflammation and adhesion-related processes, and in signal transduction, such as phosphatidylinositol signaling system and adenosine triphosphate binding cassette transporters. Altogether, 49% of AS-related exons were protein coding, and domain prediction showed 28% of such exons to include a functional domain, such as transmembrane helix domain or phosphorylation sites. Validation in an independent cohort of 92 DLBCL samples subjected to RNA-sequencing confirmed differential exon usage of selected genes and association of AS with molecular subtypes and survival. The results indicate that AS events are able to discriminate GCB and ABC DLBCLs and have prognostic impact in DLBCL.
High sensitivity blood-based M-protein detection in sCR patients with multiple myeloma
Authors: Mills J R , Barnidge D R , Dispenzieri A , Murray D L 
Published: August 2017

AbstractWe assessed the ability of a mass spectrometry-based technique, called monoclonal immunoglobulin rapid accurate mass measurement (miRAMM), to extend the analytical range of M-protein detection in serum samples obtained from myeloma patients in stringent complete response (sCR) post-autologous stem cell transplant (ASCT). To aid the M-protein detection post ASCT, the accurate molecular mass of the M-protein light chain at diagnosis was determined in all patients (N=30) and used to positively identify clones in the sCR serum. Day 100 post-ASCT, sCR samples had miRAMM identifiable M-proteins in 81% of patients. Patients who had achieved only a partial remission (PR) pre-ASCT and those with IgG isotypes serum samples had the highest rate of M-protein detection by miRAMM. miRAMM positivity at single time points (day 100, 6 months or 12 months) did not correlate with progression-free survival (PFS). In contrast, sCR patients who did not decrease their miRAMM M-protein intensities in serial measurements had shorter PFS than those whose miRAMM intensities decreased (median 17.9 months vs 51.6 months; P<0.0017). miRAMM M-protein is a more sensitive blood-based test than traditional M-protein tests and could cost effectively aid in serially monitoring complete remission for continue response or biochemical relapse.
Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group
Authors: Hillengass J , Moulopoulos L A , Delorme S , Koutoulidis V , Mosebach J , Hielscher T , Drake M , Rajkumar S V , Oestergaard B , Abildgaard N , Hinge M , Plesner T , Suehara Y , Matsue K , Withofs N , Caers J , Waage A , Goldschmidt H , Dimopoulos M A , Lentzsch S , Durie B , Terpos E 
Published: August 2017

AbstractFor decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P<0.0001). Of 66 patients with SMM based on CSS, 12 (22.2%) had osteolytic lesions on WBCT. In comparison, WBCT failed to detect some bone destructions in the appendicular skeleton possibly due to limitations of the field of view. Presence of lytic bone lesions in WBCT was of borderline prognostic significance (P=0.051) for SMM patients, with a median time to progression of 38 versus 82 months for those without bone destructions. In conclusion, WBCT identifies significantly more sites of bone destruction than CSS. More than 20% of patients with SMM according to CSS have in fact active MM detectable with WBCT. On the basis of this and other studies, WBCT (either computed tomography (CT) alone or as part of a positron emission tomography-CT protocol) should be considered the current standard for the detection of osteolytic lesions in MM.
A 3D magnetic tissue stretcher for remote mechanical control of embryonic stem cell differentiation
Authors: Du Vicard , Luciani Nathalie , Richard Sophie , Mary Gaëtan , Gay Cyprien , Mazuel François , Reffay Myriam , Menasché Philippe , Agbulut Onnik , Wilhelm Claire 
Published: August 2017

AbstractThe ability to create a 3D tissue structure from individual cells and then to stimulate it at will is a major goal for both the biophysics and regenerative medicine communities. Here we show an integrated set of magnetic techniques that meet this challenge using embryonic stem cells (ESCs). We assessed the impact of magnetic nanoparticles internalization on ESCs viability, proliferation, pluripotency and differentiation profiles. We developed magnetic attractors capable of aggregating the cells remotely into a 3D embryoid body. This magnetic approach to embryoid body formation has no discernible impact on ESC differentiation pathways, as compared to the hanging drop method. It is also the base of the final magnetic device, composed of opposing magnetic attractors in order to form embryoid bodies in situ, then stretch them, and mechanically stimulate them at will. These stretched and cyclic purely mechanical stimulations were sufficient to drive ESCs differentiation towards the mesodermal cardiac pathway.
Assessment of selected media supplements to improve F/HN lentiviral vector production yields
Authors: Gélinas Jean-François , Davies Lee A. , Gill Deborah R. , Hyde Stephen C. 
Published: August 2017

AbstractThe development of lentiviral-based therapeutics is challenged by the high cost of current Good Manufacturing Practices (cGMP) production. Lentiviruses are enveloped viruses that capture a portion of the host cell membrane during budding, which then constitutes part of the virus particle. This process might lead to lipid and protein depletion in the cell membrane and affect cell viability. Furthermore, growth in suspension also causes stresses that can affect virus production yields. To assess the impact of these issues, selected supplements (Cholesterol Lipid Concentrate, Chemically Defined Lipid Concentrate, Lipid Mixture 1, Gelatin Peptone N3, N-Acetyl-L-Cysteine and Pluronic F-68) were assayed in order to improve production yields in a transient transfection production of a Sendai virus F/HN-pseudotyped HIV-1-based third generation lentiviral vector in FreeStyle 293 (serum-free media) in suspension. None of the supplements tested had a significant positive impact on lentiviral vector yields, but small non-significant improvements could be combined to increase vector production in a cell line where other conditions have been optimised.
Increased expression of Siglec-9 in chronic obstructive pulmonary disease
Authors: Zeng Zhilin , Li Miao , Wang Meijia , Wu Xiaomei , Li Qinghai , Ning Qin , Zhao Jianping , Xu Yongjian , Xie Jungang 
Published: August 2017

AbstractChronic obstructive pulmonary disease (COPD) is a common inflammatory lung disease. Sialic acid-binding immunoglobulin-type lectins 9 (Siglec-9) is predominantly expressed on innate immune cells and has been shown to exert regulatory effect on immune cells through glycan recognition. Soluble Siglec-9 (sSiglec-9), the extracellular region of Siglec-9, might fulfill its function partly by competitive inhibiting siglec-9 binding to its ligands; however, the role of Siglec-9 and sSiglec-9 in the pathogenesis COPD remain largely unknown. In this study, we showed that Siglec-9 expression in alveolar and peripheral blood neutrophil were increased in COPD patients by immunofluorescence and flow cytometry, respectively. Plasma levels of sSiglelc-9 were elevated in COPD patients by ELISA. In vitro, Siglec-9 expression and/or sSiglelc-9 levels were up-regulated by cigarette smoke extract (CSE), lipopolysaccharide (LPS), some cytokines, and dexamethasone (DEX). Recombinant sSiglce-9 increased oxidative burst in neutrophil and enhanced neutrophil chemotaxis toward IL-8 independent on CXCR1 and CXCR2 expression, but it did not affect neutrophil apoptosis or secretions of inflammatory cytokines. In conclusion, Siglec-9 was complementarily increased to induce a negative feedback loop to limit neutrophil activation in COPD, sSiglce-9 enhanced neutrophil ROS and chemotaxis toward IL-8 likely via competitively inhibiting ligands binding to Siglec-9.