bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Social and Structural Determinants on Depression, Prescription Opioid Use, Opioid Misuse, and Opioid Use Disorder
Authors: Rottnek Fred , Bello-Kottenstette Jennifer K 
Published: October 2024

Abstract
The impact of social and structural determinants of health (SSDOH) on pain, depression, and prescription opioid use, misuse, and development of opioid use disorder (OUD) is complex and multifactorial. SSDOH are rooted in systems fraught with systemic racism that exacerbate intergenerational poverty through the cycle of chronic stress, psychological trauma, and deprivation that lead to poor mental health and substance use. The chapter describes the five domains of SSDOH outlined by Healthy People 2030 and gives examples of how each domain impacts pain, depression, and opioid use. It explains the need for an interdisciplinary approach that extends beyond a traditional healthcare model to address the interconnected problems of pain, depression, and OUD at individual, family, and community levels.
The sky's the limit: improving satellite imagery data literacy to address non-communicable diseases
Authors: Hughes M Courtney , Folkmann Elizabeth J 
Published: October 2024

Abstract
Low-and middle-income countries experience 77% of the world's premature deaths caused by non-communicable diseases, and their underlying health determinant data are often scarce and inaccurate. Improving satellite imagery data literacy worldwide is an integral step toward using the vast amount of publicly available data collected via satellites, such as air pollution, green space and light at night—all determinants of non-communicable diseases. Existing machine learning–based algorithms enable automated analysis of satellite imagery data, but health officials and scientists must know where to find and how to apply these algorithms to measure risk and target interventions.
Making the Climate Malleable? “Weak” and “Strong” Governance Objects and the Transformation of International Climate Politics
Authors: Corry Olaf 
Published: October 2024

Abstract
Object-oriented theories have been used to understand how the climate and other entities like “the economy” have been produced as discrete, malleable and politically salient “governance objects.” These have structuring effects not only on policy debates but also on entire polities and the international system. However, a failure to distinguish between different kinds of governance objects has obscured their fundamentally different political implications. This article revises earlier definitions and develops a novel distinction between “weakly” and “strongly” malleable governance objects. The former are governable only in terms of not being perturbed in relation to a baseline condition, while “strongly governable” objects are construed as malleable along multiple dimensions, the telos of governing them no longer a given. The weak/strong distinction is applied to elicit implications of four climate strategies: mitigation, adaptation, and prospective “geoengineering” techniques of carbon dioxide removal and solar radiation modification that would deliberately alter the climate. Increasingly billed as risky but necessary, given the fraught politics of mitigation, geoengineering is shown to potentially transform the climate from weak to more strongly governable object. This could “untether” climate governance from the aim of remaining close to a pre-industrial climate, with a "design approach" to geoengineering adding layers of politicization, potentially increasing the fractiousness of global climate politics. However the analysis also highlights possible new routes to depoliticization of the climate, were it to be retethered—potentially to security imperatives or economic indicators. Analysis of governance objects requires much greater attention to types of malleability and politicization.
Oliver Goldsmith’s Indigent Philosopher, U.S. Foreign Policy, and Three American Editions of The Vicar Of Wakefield, 1791–1839
Authors: Ross Ian Campbell 
Published: October 2024

Abstract
Oliver Goldsmith is not usually associated with the foreign policy of the United States. Nevertheless a speech attributed to the ‘Indigent Philosopher’, first published in the London Lloyd’s Evening Post in February 1762 and included in Goldsmith’s Essays (1765; 2nd corrected edn 1766), was reprinted on three separate occasions, at the conclusion of new editions of the author’s The Vicar of Wakefield (1766). The editions were published in the-then US capital of Philadelphia in 1791 and 1795, and in the new capital, Washington, in 1839. The speech, an exhortation not to declare war against Spain, has a direct relevance to three distinct historical moments, however unexpected the context of republication.
Children who are HIV exposed-uninfected: does maternal ART regimen matter?
Authors: Ellis Richard Patrick , Evans Ceri , Wedderburn Catherine J. , Prendergast Andrew J. 
Published: October 2024

Purpose of review
Differences in health outcomes between children who are HIV-exposed but uninfected (CHEU) compared to children who are HIV-unexposed (CHU) have been reported both before and since the availability of antiretroviral therapy (ART) during pregnancy and breastfeeding. This review highlights recent studies investigating the impact of ART on the health, growth and development of CHEU.

Recent findings
Several meta-analyses confirm higher rates of adverse birth outcomes among pregnant women with HIV compared to pregnant women without HIV. The highest risk of adverse birth outcomes is among women with HIV not receiving ART, and generally studies indicate that more time on ART is associated with lower risk of adverse birth outcomes; however, most data are from observational cohorts. Where studies have compared historic regimens, prior to dolutegravir use, adverse birth outcomes are more commonly associated with exposure to protease inhibitors. Recent population-based studies have not demonstrated an association between neural tube defects and dolutegravir exposure. In a recent, multisite randomized trial, infants born to mothers receiving dolutegravir vs. efavirenz had lower neonatal mortality, possibly mediated through reductions in small-for-gestational age and preterm birth. Neurodevelopment, neuroimaging and growth studies suggest a protective effect of earlier maternal ART initiation.

Summary
Dolutegravir continues to appear safe in pregnancy. Randomized trials of specific regimens during pregnancy and breastfeeding, including long-acting and newer ART drugs with long-term follow-up of children, are critical to understand the contribution of ART exposure to CHEU outcomes.
An update on surgical management for stress urinary incontinence
Authors: Gallo Kelsey , Weiner Hillary , Mishra Kavita 
Published: October 2024

Purpose of review
Stress urinary incontinence (SUI) is a common condition for which women often opt for surgical management. Synthetic midurethral slings (MUS) have been the dominant treatment for decades. Single-incision slings (SIS) have been introduced to lower the morbidity associated with trocar passage during MUS placement. Urethral bulking has been used less frequently owing to its lower cure rates. New data have recently emerged in support of single-incision slings (SIS) and urethral bulking with Bulkamid polyacrylamide hydrogel (PAHG).

Recent findings
Several studies with a follow-up ≥10 years have shown stable efficacy and complication rates of retropubic (RMUS) and transobturator (TMUS) midurethral slings over time. SIS products show equivalent efficacy to traditional TMUS and RMUS at up to 3 years of follow-up and can be placed under local anesthesia. While urethral bulking with PAHG results in lower cure rates compared to slings, satisfaction rates are high and responders have sustained improvement at 7 years follow-up.

Summary
All three types of available slings, TMUS, RMUS, and SIS, are now considered appropriate surgical options for the treatment of SUI. Although the absence of comparative data precludes a formal recommendation for one injectable over another, urethral bulking with PAHG has favorable long-term results and an excellent safety profile.
Does the Timing of Orthognathic Surgery Affect the Level of External Root Resorption?: Surgery-First Approach Versus Conventional Orthognathic Surgery
Authors: Albayrak Elif , Buyukcavus Muhammed Hilmi , Sari Ömer Faruk , Findik Yavuz 
Published: October 2024

Objective:
This study aimed to compare external root resorption levels, both linearly and areally, on panoramic radiographs in Class III patients whose treatment was completed with the conventional orthognathic surgery and the surgery-first approach.

Methods:
The study included 20 patients (10 female, 10 male; 23.98±2.63 y) treated with conventional orthognathic surgery and 18 patients (8 female, 10 male; 27.5±3.42 y) treated with surgery-first approach was included. Linear and area measurements were made on the digital panoramic radiographs taken before and at the end of the treatment of 38 patients who constituted the sample of the study. The mean changes observed in each group were evaluated using a paired t test. The chronological ages, skeletal features (type of Class III malocclusion), treatment durations, initial values, and mean changes that occurred in each group were compared using independent t test.

Results:
When the changes in root lengths and root surface areas were evaluated in all teeth in both groups, a significant loss in size was measured (P<0.001). More resorption was observed in teeth 12 and 22 in the conventional surgery group (P<0.05). When the amount of resorption in both groups was compared, there was significantly more resorption in tooth number 12 in the conventional surgery group (P<0.05).

Conclusion:
The study showed that there was external root resorption in all teeth in both protocols, but the root lengths of the lateral teeth were shortened more in both groups.
The Impact of Lexical-semantic Impairment on Spoken Verb Production in Individuals With Mild Cognitive Impairment
Authors: Macoir Joël , Laforce Robert , Hudon Carol 
Published: October 2024

Background:
Although episodic memory is the primary concern in individuals with mild cognitive impairment (MCI), other cognitive functions may also be affected, including language. Language impairment in individuals with MCI has been attributed primarily to the breakdown of semantic representations, difficulties in accessing semantic information, and the weakening of executive functions. However, in most prior studies of word processing in individuals with MCI, researchers have used measures focused on noun production.

Objective:
To investigate how verb production tasks might aid in detecting cognitive impairment in individuals with MCI.

Methods:
We compared the performance of 45 individuals with MCI and 45 healthy controls on action naming and action fluency tasks.

Results:
In the action naming task, the performance of participants with MCI was significantly impaired compared to healthy controls in terms of total score, the number of semantic errors produced, and the use of generic terms. In the action fluency task, participants with MCI produced significantly fewer verbs, fewer clusters, and fewer switches than healthy controls.

Conclusion:
The results of our study emphasize the utility of verb production tasks in the identification of cognitive impairment in individuals with MCI and provide evidence of the importance of including action naming and action fluency tasks in the assessment of individuals with MCI.
Taxation and entrepreneurship of migrant workers: evidence from China
Authors: Huang Lulu , Jiao Conghui , Liu Qiannan 
Published: October 2024

PurposeMigrant workers play a vital role in the development of countries such as China. However, they often face greater barriers in entrepreneurship. Yet, few studies have focused on the effect of institutional factors on migrant workers' entrepreneurial behaviors. To address this gap, this study concentrates on the role of taxation.Design/methodology/approachThis study takes the agricultural tax abolition reform implemented in rural China since 2004 as an exogenous shock and uses the difference-in-difference (DID) method to examine its effect on migrant workers' entrepreneurship based on longitudinal data from the China Health and Nutrition Survey (CHNS).FindingsWe find that the reform significantly improves the probability of migrant workers engaging in entrepreneurship. Heterogeneity analysis reveals that the reform exerts a notably more pronounced positive impact on male, younger and migrant workers in the Western region. Further analysis reveals that the three main mechanisms are increased household income, female human capital accumulation and increased social capital, including social networks and social trust.Originality/valueThis study is first to offers an institutional perspective on the determinants of migrant workers' entrepreneurship in China. Additionally, the study can provide insights for policymaking intended to support employment and entrepreneurship among low-skill migrant workers.
Child leader standing on a precipice: a case study of NextGenInnov8
Authors: Sinha Saloni , Faridi Mohammad Rishad , Cheema Surbhi 
Published: October 2024

Learning outcomes
After completion of the case study, students will be able to identify the traits required in child leadership and the ability to apply “The Whole Leadership Framework” child leadership model today, identify and discover opportunities to promote child leadership and analyse its sustainable impact and analyse how innovation clubbed with sustainability will create a competitive advantage with special reference to the innovative ultraviolet-C light sterilisation Suraksha Box.

Case overview/synopsis
Aditya Pachpande was a child prodigy of India, who had stunned the world with his trailblazing attitude ever since the tender age of 12. Aditya’s father, Sandeep Pachpande, a Harvard alumnus, wondered – “My son is ahead of his time. Would institutions ever acknowledge my innovative boy as a child leader? Will my child become a teen chief executive officer (CEO)? Will he ever get accepted?” Aditya leads by example as a student, changemaker, edupreneur, innovator and keynote speaker. He thinks, “Age is just a number”, but has had to shout out loud to be heard. With the nickname “Lecture man” given by his teachers and peers, he went on to contribute in endorsing skill-based experiential and discovery-based teaching-learning that addresses real-world issues and sustainable development goals. A CEO at the age of 11 years, he co-founded NextGenInnov8 Global Solutions Private Limited and NextGenInnov8 Social Foundation. Although achieving these milestones, he had to manoeuvre through several curve balls hurled at him by the system. Not the one to ever compromise on ethics, values and purpose, today he was at the crossroads – whether he should choose social change over-commercialisation of his business, simplicity and minimalism over product perfection, crowdfunding over loans or angel investors, manufacture in China or make in India just to name a few. The unstoppable Aditya, aspiring for acceptance, dreamt that someday, these policymakers and businesses would acknowledge child innovators and not write them off just because they were adolescents. Aditya, standing on a precipice, dreamt along.

Complexity academic level
This case has been particularly focused on postgraduate-early stage-level students pursuing business or entrepreneurial education-related programs.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 3: Entrepreneurship.
Preventive health-care behavior: a serial multiple mediation analysis
Authors: De Gourab , Joshi Himanshu , Sondhi Neena , Bhattacharjee Ayona 
Published: October 2024

Purpose
Preventive health-care behavior (PHB) adoption as a primordial prevention to stay healthy and avoid lifestyle disease risk is a global trend. This paper aims to use the PHB model and stimulus-organism-response theory to empirically examine the role of individual and technological factors in influencing primordial PHB.

Design/methodology/approach
A sequential mixed-method was adopted to identify the primordial PHB adoption and propose a conceptual framework. The identified determinants and the hypothesized relationships were empirically tested using a convenience sample of 406 urban Indians. Partial least square structural equation modeling is used for data analysis.

Findings
The derived conceptual framework was empirically tested to assess the role of health literacy (HL), health value (HV) and digital health information seeking (DHIS) on primordial PHB. Findings confirmed the significant influence of DHIS on HL, HL on HV and PHB and HV on PHB. The direct effects of DHIS on PHB and HV were insignificant. HL solely mediated the indirect effect of DHIS on PHB, while the mediation of HV was insignificant. HL and HV fully mediated the relationship between DHIS and PHB.

Research limitations/implications
The impact of DHIS on PHB adoption and the serial multiple mediating roles of HL and HV are significant in understanding primordial PHB adoption for both academic theory and practice. However, the cross-sectional study on urban Indians needs further validation across geographies.

Originality/value
To the best of the authors’ knowledge, this pioneering study is among the first to propose and validate a comprehensive model of primordial PHB adoption.
Create and strengthening innovation ecosystem: roles of policy-affiliated transition intermediaries in latecomers
Authors: Attarpour Mohammadreza , Elyasi Mehdi , Mohammadi Akbar , Rezaalizadeh Hosein 
Published: October 2024

Purpose
This study aims to explore the functions of policy-affiliated intermediaries and their roles in driving innovation in latecomers.

Design/methodology/approach
Latecomers have recently recognized the significance of an innovation ecosystem in transitioning to an innovation-driven economy. However, these countries encounter various market and system failures, making policy-affiliated transition intermediaries crucial in orchestrating innovation ecosystems. To achieve this, this study used a case study of a policy-affiliated intermediary and conducted interviews with 19 managers. The results from the content analysis revealed that innovation intermediaries in latecomers perform more comprehensive duties than those mentioned in the literature in the transition to innovation-based development.

Findings
Results show that the most important of policy-affiliated innovation intermediaries’ roles is orientation to the government and private sector market, attracting the participation of the private sector through the implementation of tax credits and the development of the corporate innovation ecosystem, developing science and technology parks, developing laboratory research infrastructure, supporting prominent and capable professors to create innovation networks, developing innovation zones around research institutions and leading universities and developing international scientific cooperation. These are new and important functions that innovation intermediaries should play in the transition process.

Originality/value
The research found that the innovation intermediary acts as a change agent in the mental model of other executive and decision-making bodies. Also result shows that this intermediaries can play more roles than what is mentioned in the literature for the development of innovation.
Estimation of tributary–mainstem migration of freshwater fishes by Sr isotope analysis of otoliths
Authors: Ohta Tamihisa , Sueyoshi Masanao , Shima Momoko , Ida Shinichiro , Iizuka Tsuyoshi 
Published: October 2024

AbstractThe study of fish movement patterns in freshwater ecosystems remains a major focus of contemporary research. Small freshwater fish are known to migrate between tributaries and mainstems at different stages of their life history, helping to avoid local extinctions and maintain genetic diversity. However, fitting small fish species with telemetry equipment is difficult, making it challenging to track their detailed migration history via conventional methods. We evaluated the suitability of otolith isotope analysis for verifying the migration histories of small fish species inhabiting small tributaries. In this study, we compared the 87Sr/86Sr values in stream water and the otoliths of two fish species (Nipponocypris temminckii and Rhinogobius flumineus) inhabiting small streams. The 87Sr/86Sr ratios in the stream waters within the study area displayed considerable variation among tributaries. Our findings indicate that only N. temminckii has high dispersal ability, showing movement between tributaries or between tributaries and the mainstem in some locations. In contrast, such movement was not generally observed for R. flumineus. These results show the potential of 87Sr/86Sr as a tool for estimating the migration patterns of small fishes that inhabit small tributaries.
What lies behind France's low level of income inequality?
Authors: Bozio Antoine , Guillot Malka , Puschnig Lukas , Tô Maxime 
Published: October 2024

AbstractWe document the evolution of working‐age individual pre‐tax and disposable income inequality in France since the late 1960s using household surveys. Disposable income inequality declined over the 1960s and 1970s and remained stable thereafter. This trend can be explained, in part, by changes in the tax and benefit system, notably through changes in employer contributions, and the evolution of the national minimum wage. Other dimensions than income bring a less positive perspective: low‐income individuals are now more likely to be immigrants, have low education, and live in households with no working adults.
DYNC2H1 splicing variants causing severe prenatal short‐rib polydactyly syndrome and postnatal orofaciodigital syndrome
Authors: Porto Vasconcelos Alice , Quental Sofia , Freixo João Parente , Pacheco João Machado , Rodrigues Sofia , Magalhães Magda , Oliveira Renata , Braga Ana Costa , Quental Rita 
Published: October 2024

AbstractThe DYNC2H1 gene has been associated with short‐rib polydactyly syndrome (SRPS), among other skeletal ciliopathies. Two cases are presented of distinctive phenotypes resulting from splicing variants in DYNC2H1. The first is a 14‐week‐old fetus with enlarged nuchal translucency, oral hamartoma, malformed uvula, bifid epiglottis, short ribs, micromelia, long bone agenesis, polysyndactyly, heart defect, pancreatic cysts, multicystic dysplastic kidney, megabladder and trident acetabulum. A ciliopathies NGS panel revealed two compound heterozygous variants in DYNC2H1: c.7840‐18T>G r.7841_7964del p.Gly2614Aspfs*5 and c.11070G>A r.11044_11116del p.Ile3682Aspfs*2. Both variants were initially classified as variants of uncertain significance but were reclassified as likely pathogenic after PCR‐based RNA testing. The second is an 11‐year‐old overweight male with multiple accessory oral frenula, median cleft lip and alveolar ridge, polysyndactyly, brachydactyly, normal rib length, and hypogonadism. Exome sequencing revealed two compound heterozygous variants in DYNC2H1: c.6315del p.(Thr2106Glnfs*7), classified as likely pathogenic, and c.3303‐16A>G p.(?), classified as a variant of uncertain significance. PCR‐based RNA testing suggested that c.3303‐16A>G induces an in‐frame deletion: r.3303_3458del p.Asp1102_Arg1153del, although the normal transcript is still produced. These results are consistent with both SRPS type I/III in the first case and orofaciodigital syndrome in the second, an unprecedented description. This work thus improves the clinical and molecular knowledge of the phenotypes associated with splicing variants in the DYNC2H1 gene.