bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyridines as novel skin protecting and anti-aging agents
Authors: Saeed Aamer , Shahzad Danish , Larik Fayaz Ali , Channar Pervaiz Ali , Mahfooz Haroon , Abbas Qamar , Hassan Mubashir , Raza Hussain , Seo Sung-Yum , Shabir Ghulam 
Published: June 2017

A series of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyri-dines 6a-6h were prepared by using the one-pot three component synthetic method. The target compounds 6a-6h were synthesized by reacting two molar equivalents of ketone functionality and one mole of aromatic aldehydes in ammonium acetate to obtain the desired products. The structures of newly synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, and elemental analysis. All the synthesized compounds were screened for their elastase inhibition and antioxidant activity. Almost all of the com-pounds 6a-h showed good to excellent activities against elastase enzyme more than the reference drug. Compounds 6d and 6b at 0.2 ± 0.0 µM and 0.2 ± 0.0 µM were found to most potent derivatives against elastase enzyme. Compound 6a exhibited prominent free radical scavenging activity. From the results of the biological activity, we infer that some derivatives can serve as lead molecules in pharmacology.
Video Clip of Methodology:
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Quand l’État convoque la rue
Authors: Boussaguet Laurie , Faucher Florence 
Published: June 2017

À contre-courant de la littérature sur les mouvements sociaux, qui envisage les manifestations comme un instrument de la société civile pour s’exprimer face au pouvoir, la marche républicaine du 11 janvier 2015 à Paris peut être vue comme une « manifestation d’État », au sens où ce sont les principaux acteurs de l’exécutif qui ont joué le rôle d’organisation du mouvement social. Certes, le choc représenté par les attentats et la vague d’émotion qui a submergé la population ont été des éléments favorables ; certes, l’initiative est venue des partis politiques et un député, organisateur officiel, a été l’une des chevilles ouvrières de ce grand rassemblement. Cependant, ce n’est qu’en regardant les actes, les gestes, les prises de parole et les discours des gouvernants que l’on peut réellement expliquer l’organisation et le succès de cette marche historique.
Les effets du Grenelle de l’environnement sur l’action publique
Authors: Halpern Charlotte , Pollard Julie 
Published: June 2017

La concertation produit-elle des effets sur l’action publique ? Ou, plus précisément, dans quelle mesure un dispositif de concertation constitue-t-il un facteur explicatif des recompositions de l’action publique sectorielle ? À partir d’une analyse comparée des effets du Grenelle de l’environnement sur deux secteurs, cet article contribue aux réflexions en cours sur les effets de la concertation, et au-delà, du rôle de la concertation dans les processus de changement dans l’action publique. Le choix d’une analyse comparée entre secteurs et, pour chaque secteur, de trois dimensions de l’action publique, permet d’identifier les effets propres au Grenelle, mais des degrés et des formes différenciés du changement sectoriel.
Le matérialisme incarné en action
Authors: Salleh Ariel , Blanchard Aurélien 
Published: June 2017

Dans cet entretien réalisé en 2010 pour la revue canadienne Polygraph , Ariel Salleh expose sa version de l’écoféminisme : un « matérialisme incarné » qui refuse le postmodernisme, valet du néolibéralisme à ses yeux, et cherche à reconstruire les notions décriées de femme et de nature. Elle en développe les implications politiques sur divers sujets d’actualité (dette écologique et postcoloniale, agro-industrie…) et justifie l’espoir qu’elle place dans la classe des « travailleurs méta-industriels » pour impulser une alternative juste et soutenable à la mondialisation.
Effets disciplinaires du dossier informatisé dans l’accompagnement social de la précarité
Authors: Thorel Jérôme 
Published: June 2017

Comment s’opère l’informatisation des processus de prestation sociale ? Comment les discours ont été adaptés pour accompagner ces nouvelles pratiques tant au niveau de l’usager que de l’agent du travail social ? L’auteur montre que l’outil informatique (et le fichage individuel qui en est le corollaire) – si souvent présenté comme objet « neutre » en ce qu’il dépendrait des seuls usages que l’on en fait – agit sensiblement, même de manière indirecte, sur la relation complexe usager-agent, et notamment sur leurs capacités à adhérer plus ou moins activement à ces processus de contrôle social.
Jacques Riboud, promoteur militant
Authors: Dehan Philippe 
Published: June 2017

Ingénieur pétrolier, Jacques Riboud se lance dans la promotion immobilière au milieu des années 50. Il vise à proposer une alternative aux grands ensembles par la construction de petites villes nouvelles privées, totalement équipées, composée très majoritairement de maisons individuelles en quartiers denses. Il conçoit la Haie Bergerie comme un premier laboratoire visant à démontrer ses thèses, qu’il promeut à travers de nombreux livres et articles. Son approche industrielle qui intègre au sein d’un même groupe l’ensemble des compétences (promotion, urbanisme, architecture et construction) se détache de celle des grands ensembles par des choix constructifs et économiques originaux et son attention aux désirs des habitants. Un exemple toujours actuel dans la perspective d’un urbanisme durable.
« La partie supérieure de l’Univers » et « la matière première » : cosmos et renovatio mundi chez Loys Le Roy et Giordano Bruno
Authors: Severini Maria Elena 
Published: June 2017

En 1575, l’humaniste courtisan Loys Le Roy dit Regius publie à Paris le traité De la vicissitude ou variété des choses en l’univers, destiné à devenir une des histoires de la civilisation parmi les plus lues en Europe aux xvie et xviie siècles. Cet article vise à identifier le modus operandi par lequel l’humaniste utilise les sources néoplatoniciennes anciennes et modernes vers une nouvelle perspective, qui, tout en tenant compte du principe de la correspondance entre le ciel et la terre et de l’harmonie universelle, met en valeur la liberté individuelle. L’érudit de Coutance retourne à Platon à travers la médiation du néoplatonisme mêlé d’une façon syncrétiste à la conception de la substance aristotélicienne. À travers l’analyse de quelques passages du traité nous visons à montrer comment Le Roy accorde ses sources avec la notion de vicissitude qui implique la persistence de la substance universelle. Sa perspective valorise la singularité et l’individualité, qui deviennent, par rapport à tout déterminisme, un point de force extraordinaire, le pivot même de la liberté humaine, le départ de tout progrès
Evaluation of pain during intravitreal aflibercept injections
Authors: Doguizi Sibel , Sekeroglu Mehmet A. , Inanc Merve , Anayol Mustafa A. , Yilmazbas Pelin 
Published: June 2017

Purpose: To evaluate the pain associated with intravitreal aflibercept injections. Methods: The study included 119 patients who received intravitreal aflibercept injection at a single institution. Pain was evaluated by visual analog scale (VAS) immediately after the injection of 2 mg/0.05 mL aflibercept into the vitreous cavity using a 27-G needle. Additional variables including age, sex, indication for the injection, injection site by quadrant (superotemporal or inferotemporal), position during injection (sitting or supine), number of previous intravitreal injections in the study eye, presence of diabetes mellitus or hypertension, and lens status (phakic or pseudophakic) were recorded and assessed with self-reported pain scores. Results: Pain scores on the VAS ranged from 9 to 70, with a median of 18. Indications for injection included diabetic macular edema (21.0%), macular edema secondary to central retinal vein occlusion (12.6%), and neovascular age-related macular degeneration (66.38%). Pain did not significantly correlate with any of the recorded variables. Conclusions: This is the first series evaluating the pain associated with intravitreal aflibercept injections. We demonstrated that pain associated with intravitreal aflibercept injection is generally mild with low pain scores.
Outcomes of nondisplaced intracapsular femoral neck fractures with internal screw fixation in elderly patients: a systematic review
Authors: Oñativia Ignacio J. , Slulittel Pablo A.I. , Diaz Dilernia Fernando , Gonzales Viezcas Juan M. , Vietto Valeria , Ramkumar Prem N. , Buttaro Martin A. , Piuzzi Nicolas S. 
Published: June 2017

Introduction: Although the preferred treatment for displaced femoral neck fractures in the elderly is hip arthroplasty, the treatment for impacted or undisplaced femoral neck fractures (UFNF) is still a subject of controversy. Our purpose was to systematically review studies of elderly patients with UFNF treated with internal fixation using screws: (i) what is the reported mortality; (ii) what is the reoperation rate; (iii) what are the clinical and radiological outcomes; and (iv) what is the methodological quality of the included studies? Methods: This systematic review was performed through a search of PubMed and the Cochrane database using a structured search algorithm including studies enrolling patients older than 60 years old, with UFNF treated with internal fixation using screws. Our literature search returned 950 studies and 11 were selected for final abstraction. Results: 6 studies reported mortality rate. At 1-year follow-up mortality was reported by 3 studies: 18.8%; 22%, and 19%. At 5 years, 1 study reported mortality rate of 42%. Overall reoperation rate was reported by 9 studies and ranged from 8%-19%, while conversion to hip arthroplasty was performed in the range between 8% and 16% according to 6 studies. Conclusions: Internal fixation with cannulated screws for UFNF in the elderly is a valuable option, although it has substantial reoperation and mortality rates. Further prospective high-quality, randomised controlled trials are required to establish the optimal approach for the treatment of UFNF.
Single-center comparison of the efficacy and complications of arterial vascular closure devices in interventional radiology
Authors: Elmasri Matthew A. , Kee Stephen T. , Moriarty John M. , Gomes Antoinette , Lee Edward W. , McWilliams Justin P. 
Published: June 2017

Introduction Vascular closure devices (VCDs) are commonly used to achieve hemostasis of arterial access sites, but there is little comparative data on the variety of VCDs currently in clinical use. We reviewed the VCD experience at our institution to determine the safest and most effective VCD. Materials and Methods Retrospective analysis of 907 consecutive arterial procedures in interventional radiology from June 2012 to June 2014 was performed. Five VCDs were used: Angio-Seal (n = 478), FISH (n = 56), Mynx (n = 56), Perclose (n = 61), and Starclose (n = 68). Patients who underwent manual compression (n = 188) without use of VCDs were also studied as a comparison group. Patient demographics and pre-procedural laboratory parameters were recorded. The technical success rate for achievement of hemostasis and complication rates were noted. Results Complete hemostasis rate (aka technical success rate) was 93.5% for Angio-Seal, 83.9% for FISH, 53.6% for Mynx, 73.7% for Perclose, 76.5% for Starclose, and 91.5% for manual compression. The differences among the devices were statistically significant (p<0.001). Fourteen major complications (1.5%) were encountered: nine with Angio-Seal (1.9%), one with Mynx (1.8%), one with Starclose (1.5%), and three with manual compression (1.6%); these differences were not statistically significant. Of the demographic and laboratory parameters studied, none were significantly correlated with hemostasis failure or development of complications. Conclusions In our single-center institutional experience, Angio-Seal is the device with the best technical success rate. Major complications of VCDs were rare, with no statistically significant difference between devices.
Port in oncology practice: 3-monthly locking with normal saline for catheter maintenance, a preliminary report
Authors: Solinas Gianfranca , Platini Francesca , Trivellato Maurizio , Rigo Carla , Alabiso Oscar , Galetto Alessandra S. 
Published: June 2017

Introduction Patients with cancer need stable venous access using central vascular devices like central venous ports and peripherally inserted central catheters that can be used for a wide range of indications. Numerous flushing protocols exist including different frequencies for catheter locking to maintain catheter patency. The aim of this retrospective study was to evaluate the incidence of lumen occlusion of central venous ports in a group of adult cancer patients, adopting a policy of locking with normal saline every three months. Methods This is a single-center retrospective observational study. During follow-up, we analyzed adult cancer patients who had undergone port insertion from January 1st, 2007 to August 31st, 2014. Flushing and locking were performed every three months with a syringe containing normal saline. Results We collected data from 381 patients with ports inserted in subclavian vein (379 patients) and in the right jugular vein (2 patients). Locking was performed during 3-monthly follow-up visits. Median follow-up was 810 days (90-2700 days). Among 381 ports, 59 were removed; the reasons for removal were: end of use (45 cases), catheter rupture (9 cases), dislocation (3 cases) and catheter-related bloodstream infection (2 cases). We had no reports of lumen occlusion. Conclusions Our data suggest that locking ports with normal saline every three months is not associated with an increased risk of lumen occlusion.
Innovation and Customer Retention in the Ghanaian telecommunication industry
Authors: Kyei Daniel Asante , Bayoh Augustine Thomas Mambu 
Published: June 2017

The competition within the telecommunication sector is increasing day by day in Ghana and therefore requires the telecom operators to be more adept in their strategic approach to meet the growing demands of customers. Effective innovation is believed to be key in the approach of wining and maintaining customers. This paper examines the effect of innovation on customer retention in the telecommunication industry in Ghana. Data were collected using self-administered questionnaires to 365 customers of 6 telecommunication companies in Accra, Ghana. Descriptive statistics and multiple regression were employed to examine the relationship between the independent and dependent variables. The result shows that there is positive and significant relationship between innovation and customer retention. The study also discloses that service innovation, process innovation, and marketing innovation were the key determinants of customer retention. The study found service innovation to be a significant chief driver of customer retention. The study recommends that telecommunication companies who desire to improve upon the level of customer retention should invest much in service innovation, process innovation, and marketing innovation.
Ureteral stricture formation after removal of proximal ureteral stone: retroperitoneal laparoscopic ureterolithotomy versus ureteroscopy with holmium: YAG laser lithotripsy
Authors: Hu Henglong , Xu Lu , Wang Shaogang , Yu Xiao , Yang Huan , Peng Ejun , Cui Lei , Li Cong 
Published: June 2017

Objective
To compare the risk of postoperative ureteral stricture formation following retroperitoneal laparoscopic ureterolithotomy (RPLU) and ureteroscopy with holmium: YAG laser lithotripsy (URSL) in patients with proximal ureteral stones.

Materials and Methods
We retrospectively reviewed the medical records of patients who underwent RPLU or URSL for proximal ureteral stones between April 2011 and May 2015. Patients were allocated into URSL group or RPLU group and the outcomes were compared.

Results
A total of 201 patients who underwent 209 procedures including 159 URSL and 50 RPLU with a median follow-up of 30 months were included. No significant difference was observed among the two groups in most baseline parameters, while the stone size was significantly larger in the RPLU group (11.37 ± 2.97 vs 14.04 ± 4.38 mm, p = 0.000). Patients in RPLU group had markedly longer operative time (p = 0.000) and longer postoperative hospital stay (p = 0.000). The initial and one-month stone-free rates were significantly higher in the RPLU group (78.6% vs 100%, p = 0.000 and 82.4% vs 100%, p = 0.001, respectively). Patients in the RPLU had a higher complication rate (18.0% vs 9.4%, p = 0.098) and lower ureteral stricture rate (2.5% vs 2.0%, p = 1.000), while the difference was not significant. Further logistic regression model identified RPLU and female sex as independent risk factors for postoperative complication (Odds Ratio[OR] = 3.57, p = 0.035 and OR = 3.57, p = 0.025, respectively); however, URSL was not an independent risk factor for the formation of postoperative ureteral stricture after adjusting confounding variables (OR = 0.90, p = 0.935).

Conclusion
RPLU and URSL have similar postoperative ureteral stricture formation risks. RPLU can provide significantly higher stone clearance rate, but relates with more postoperative complications.
ENVIRONMENTAL CHARACTERISTICS OF SOME MAJOR TYPES OF HARBORS
Authors: Elliott Francis E. , Tressler Willis L. 
Published: June 2017

The operational requirements for an ideal harbor are (Chao Hwa et al. 1945, Stewart 1945):
a. Provision for shelter from the waves of the open sea and a limited fetch*
b. Provision for shelter from strong winds from all directions.
c. Depth enough for a large vessel to maneuver over an extensive area.
d. Good holding ground for anchoring.
e. A deep draft entrance from the sea.
f. A minimum of annual expense for dredging.
g. Moderate or small tidal range,
h. Moderate tidal currents.
i. Sufficient circulation to remove contaminants.
j. A low fouling rate and relative freedom from marine borers.
k. Freedom from seiches and surges.
1. Freedom from tidal bores.
m. Freedom from ice.
n. Freedom from fog.
The reasons for these requirements are clear enough so that no further explanation seems to be necessary. Most of these operational requirements can readily be translated into physical phenomena provided by land, i.e., by configuration of the coast or topography.
NEW CONFIRMATION OF THE FORMULA FOR THE CALCULATION OF ROCK FILL DIKES
Authors: Iribarren Ramon , Nogales Casto 
Published: June 2017

In the paper entitled "Una formula para el caloulo de los diques de escollera" (A Formula for the Calculation of Rock Fill Dikes) published July 1938* there was presented the expression,
P=NA^3d/((cosa- sina)^3(d-1)^3)
where
P = weight of the individual stones or blocks in kilograms
N = 15 for dikes of natural rook fill
N = 19 for dikes of artificial block fill
A = 2h = total height of the wave that breaks on the dike,measured in meters
d = specific weight of material of the stones in tons (metric) per oubic meter
a = angle of the dike's side slope with the horizontal
CONSIDERATIONS ON THE PROBLEM OF FENDERING SYSTEMS
Authors: D'Auriac P. Angles 
Published: June 2017

Two problems arise :
(a) What performances can reasonably be expected of fendering systems?
(b) Once these performances have been established, how should the fendering system be constructed ?

The first of these questions, which the author has barely touched on, involves the calculation of probabilities and a rational solution could only be found on the basis of copious and reliable statistics.

The second question is dealt with much more comprehensively, the different systems used are reviewed, their advantages and disadvantages are compared and the conclusion reached is that every time the amount of energy to be absorbed may happen to be larger than expected, a dashpot type of shock-absorber would seem to be the most efficient system.

Consequently, the author focuses his discussion on this solution and establishes a mathematical theory making it possible either to design a dashpot for a given problem or to calculate the operating characteristics for a given dashpot under given conditions.
RHYTHMIC PATTERN OF LONGSHORE BARS RELATED TO SEDIMENT CHARACTERISTICS
Authors: Hom-ma Masashi , Sonu Choule 
Published: June 2017

Despite a number of valuable contributions by many predecessors, namely F. F. Shepard (Ref. 1) and Q. H. Keulegan (Ref. 2), our knowledge regarding the effect of a longshore bar on the sedimentary process of a coast has long remained a plausible, qualitative understanding that a longshore bar constitutes a zone of active migration of bottom deposit due to agitation of breakers and currents. This was probably due mainly to the difficulty of performing an accurate hydrographic survey near the breaker zone. On the other hand, the geometrical characteristics along a single bar profile, which was sounded off either from a stable pier (Ref. 1) or a suspended cable (Ref. 3) resulted in a hopeless scatter.
An aerial photograph, if taken under favorable conditions, may show an Interesting picture of submerged topographies In a distinct contrast made by the bright tone of a shallow bar crest or a shoal, against the dark background of a deep trough or a rock bottom. By comparing such photographic records with convenient soundings derived from some of the Japanese coasts, an Interesting topographical feature of a longshore bar has been disclosed. A longshore bar may attain a rhythmic pattern consisting of echelons of arcuate (or lunate) bar unit, which in entire appearance strongly resembles that of a honeycomb. It has also been discovered that a rhythmic bar pattern is correlated with other Important factors either dynamic or static, which participate in the general processes of a coast, namely the shoreline configuration, the shoreface slope and deposit, the topographies on the offshore bottom, transformation of Incident waves, the longshore currents and the littoral drifts. The authors have further attempted to develop a hypothetical concept on the origin of littoral rhythms as well as the behaviors of alongshore movement of sediment, and to consider their engineering lmplications on the basis of such findings. Although our success which has been achieved so far is yet incomplete due to lack of available data, it is believed that the approach and concept as proposed in the present paper may suggest an encouraging line of research toward formulating a unified macroscopic view on the mechanics of the littoral process.
EFFECT OF ENTRANCE ON SEICHE MOTION IN OCEAN PORTS
Authors: Roy Nikhilesh 
Published: June 2017

The seiche motion induced in a partially open harbour is uniquely determined by the standing wave pattern formed in the outside ocean. The variable location and size of the coupling makes the problem essentially three-dimensional. Existing potential theory has been extended, for the case of a simple rectangular port, to simulate ocean conditions by approximating the open ocean by another rectangular basin of large size. The theoretical problem then reduces to solving the Neunan problem for the two-dimensional Helmholtz equation V*F + K*F m o for a polygonal contour. The finite dimensional approximation of an infinite domain is, however, unsatisfactory at least from the analytical point of view.
This difficulty has been removed, in this paper, by using elliptic-cylindrical co-ordinates for the semi-infinite domain in which the perturbation potential has been expanded in terms periodic Mathieu functions. These theoretical developments have been verified by a series of numerical calculations and experimental studies.