bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pomalidomide Plus Low-Dose Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma and Renal Impairment: Results From a Phase II Trial
Authors: Dimopoulos Meletios , Weisel Katja , van de Donk Niels W.C.J. , Ramasamy Karthik , Gamberi Barbara , Streetly Matthew , Offidani Massimo , Bridoux Frank , de la Rubia Javier , Mateos Maria-Victoria , Ardizzoia Antonio , Kueenburg Elisabeth , Collins Shona , Di Micco Antonia , Rosettani Barbara , Li Yan , Bacon Pamela , Sonneveld Pieter 
Published: February 2018

Purpose Renal impairment (RI) limits treatment options in patients with relapsed/refractory multiple myeloma (RRMM). Here, we prospectively studied pomalidomide plus low-dose dexamethasone (LoDEX) in patients with RRMM and moderate or severe RI, including those receiving hemodialysis. Patients and Methods MM-013, a noncomparative, European phase II trial, enrolled three patient cohorts: moderate RI (cohort A; estimated glomerular filtration rate, 30 to < 45 mL/min/1.73 m2); severe RI (cohort B; estimated glomerular filtration rate, < 30 mL/min/1.73 m2); and severe RI that requires hemodialysis (cohort C). Patients received pomalidomide 4 mg/d on days 1 to 21 and LoDEX 20 or 40 mg once per week in 28-day cycles. The primary end point was overall response rate. Results Of 81 enrolled patients (33, 34, and 14 patients in cohorts A, B, and C, respectively), 13 were still receiving treatment at data cutoff (January 28, 2017). Overall response rates were 39.4%, 32.4%, and 14.3%, with a median duration of response of 14.7 months, 4.6 months, and not estimable, respectively. Of importance, 100%, 79.4%, and 78.6% of patients, respectively, achieved disease control. With a median follow-up of 8.6 months, median overall survival was 16.4 months, 11.8 months, and 5.2 months, respectively. Complete renal responses were observed only in cohort A (18.2%), and no patients in cohort C became hemodialysis independent. Grade 3 and 4 hematologic treatment-emergent adverse events and pomalidomide discontinuations as a result of treatment-emergent adverse events occurred more frequently in cohort C. Pomalidomide pharmacokinetics were comparable among the three renal cohorts. Conclusion Pomalidomide 4 mg/d plus LoDEX is efficacious in patients with RRMM with moderate or severe RI, including those who had more advanced disease and required hemodialysis. The safety profile was acceptable among the three groups, and no new safety signals were observed.
Nanocomposite of Conjugated Polymer/Nano-Flowers Cu(II) Metal-Organic System with 2-Methylpyridinecarboxaldehyde Isonicotinohydrazide as a Novel and Hybrid Electrode Material for Highly Capacitive Pseudocapacitors
Authors: Ehsani Ali , Bigdeloo Mohammad , Ansari Mahboubeh Yousefi , Mirtamizdoust Babak , Heidari Ali Akbar , Hadi Mojtaba , Shiri Hamid Mohammad 
Published: February 2018

Abstract
Herein, Cu2[2-mpinh (2-methylpyridinecarboxaldehyde isonicotinohydrazide)2Cl2(H2O)]n or [Cu2(2-mpinh)2Cl2(H2O)]n was first fabricated through a chemical method, and subsequently, POAP/[Cu2(2-mpinh)2Cl2(H2O)]n hybrid films were prepared using electro-polymerization of POAP, carried out in the presence of the as-prepared [Cu2(2-mpinh)2Cl2(H2O)]n nanoparticles, to apply as the active electrode in an electrochemical supercapacitor application. Not only surface analyses but also electrochemical techniques, including cyclic voltammetry, galvanostatic charge–discharge experiments along with electrochemical impedance spectroscopy, were conducted to characterize the prepared [Cu2(2-mpinh)2Cl2(H2O)]n composite films and examine the performance of the system, respectively. In this study, novel nanocomposite materials are presented for electrochemical redox capacitors possessing the merits of high active surface area and high stability in an aqueous electrolyte, as well as ease of fabrication.
Detection of vertebral metastases: a comparison between the modified Dixon turbo spin echo T
2 weighted MRI and conventional T
1 weighted MRI: a preliminary study in a tertiary centre
Authors: Hahn Seok , Lee Young Han , Suh Jin-Suck 
Published: February 2018

Objective:
To compare the diagnostic performance of modified Dixon (mDixon) turbo spin echo (TSE) T 2 weighted MRI and conventional T 1 weighted MRI in vertebral metastasis detection.

Methods:
Between September 2014 and October 2016, 33 patients with 68 metastases who had undergone whole-spine MRI were enrolled. The following sagittal image sets were evaluated: T 1WI, and mDixon TSE T 2 weighted water and fat images. Two radiologists independently evaluated each image-set for metastasis. The MR findings were compared with positron emission tomography-CT (PET-CT) scans. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for each sequence. The diagnostic performance of each sequence was evaluated using receiver operating characteristic (ROC) curves.

Results:
Sensitivity, specificity, PPV and NPV for reviewer 1 were 83.8, 99.1, 89.1 and 98.6%, respectively, with T 1WI; 79.4, 98.8, 85.7 and 98.2%, respectively, with mDixon TSE T 2 weighted water imaging; and 86.8, 99.1, 89.4 and 98.8%, respectively, with mDixon TSE T 2 weighted fat imaging. For reviewer 2, the respective scores were 91.2, 99.2, 91.2 and 99.2%; 85.3, 99.5, 93.4 and 98.7%; and 89.7, 99.3, 92.4 and 99.1%. With PET-CT as the gold standard, the ROC curves of the three sequences showed no significant difference (all p &gt; 0.05).

Conclusion:
The diagnostic performance of mDixon TSE T 2 weighted water and fat imaging was comparable to that of conventional T 1WI in the detection of vertebral metastases.

Advances in knowledge:
mDixon TSE T 2WI can be a good alternative to conventional T 1WI for detecting vertebral metastases.
Εγκαταστάσεις υγιεινής στη μεσαιωνική πόλη της Ρόδου
Authors: ΚΑΣΔΑΓΛΗ (Anna-Maria KASDAGLI) Άννα-Μαρία 
Published: February 2018

Το άρθρο παρακολουθεί την εξέλιξη της έρευνας στον τομέα της αστικής υγιεινής στη μεσαιωνική πόλη της Ρόδου κατά την Ιπποτοκρατία. Η αποκάλυψη αποχωρητηρίων στις οχυρώσεις της πόλης και σε δημόσια κτήρια στο εσωτερικό της κατά την ανασκαφική διερεύνηση που διενεργήθηκε στο πλαίσιο των μελετώναποκατάστασης συγκεκριμένων μνημείων, οδήγησε στη μελέτη της βιβλιογραφίας που αναλύει πρακτικές σχετικές με την υγιεινή στις πόλεις του Μεσαίωνα, καιστη διαμόρφωση υποθέσεων σχετικά με τη λειτουργία της ιπποτικής Ρόδου στον συγκεκριμένο τομέα.
Issues Identified by Postdischarge Contact after Pediatric Hospitalization: A Multisite Study
Authors: Rehm Kris P. , Brittan Mark S. , Stephens John R. , Mummidi Pradeep , Steiner Michael J. , Gay James C. , Ayubi Soleh Al , Gujral Nitin , Mittal Vandna , Dunn Kelly , Chiang Vincent , Hall Matt , Blaine Kevin , O'Neill Margaret , McBride Sarah , Rogers Jayne , Berry Jay G. 
Published: February 2018

BACKGROUNDMany hospitals are considering contacting hospitalized patients soon after discharge to help with issues that arise.OBJECTIVESTo (1) describe the prevalence of contact‐identified postdischarge issues (PDI) and (2) assess characteristics of children with the highest likelihood of having a PDI.DESIGN, SETTING, AND PATIENTSA retrospective analysis of hospital‐initiated follow‐up contact for 12,986 children discharged from January 2012 to July 2015 from 4 US children's hospitals. Contact was made within 14 days of discharge by hospital staff via telephone call, text message, or e‐mail. Standardized questions were asked about issues with medications, appointments, and other PDIs. For each hospital, patient characteristics were compared with the likelihood of PDI by using logistic regression.RESULTSMedian (interquartile range) age of children at admission was 4.0 years (0‐11); 59.9% were non‐Hispanic white, and 51.0% used Medicaid. The most common reasons for admission were bronchiolitis (6.3%), pneumonia (6.2%), asthma (5.1%), and seizure (4.9%). Twenty‐five percent of hospitalized children (n = 3263) reported a PDI at contact (hospital range: 16.0%‐62.8%). Most (76.3%) PDIs were related to follow‐up appointments (eg, difficulty getting one); 20.8% of PDIs were related to medications (eg, problems filling a prescription). Patient characteristics associated with the likelihood of PDI varied across hospitals. Older age (age 10‐18 years vs <1 year) was significantly (P < .001) associated with an increased likelihood of PDI in 3 of 4 hospitals.CONCLUSIONSPDIs were identified often through hospital‐initiated follow‐up contact. Most PDIs were related to appointments. Hospitals caring for children may find this information useful as they strive to optimize their processes for follow‐up contact after discharge.
Centros Comerciales a Cielo Abierto como política de renovación de las centralidades tradicionales en el Conurbano Bonaerense
Authors: Vecslir Lorena , Rodriguez Luciana 
Published: February 2018

El presente trabajo propone un análisis comparativo de diversas iniciativas de renovación de las centralidades tradicionales en el Conurbano Bonaerense bajo el modelo de Centros Comerciales a Cielo Abierto. Se parte del origen del concepto y de las primeras experiencias en Estados Unidos y Europa entre los años setenta y ochenta, para luego relacionarlas con la circulación de ideas hacia Latinoamérica una década más tarde y, en especial, con su reinterpretación y aplicación en la región metropolitana de Buenos Aires desde inicios de los 2000. Se estudia el patrón de distribución territorial de estas políticas, el tamaño y tipo de operaciones, el grado de realización, los actores involucrados y la articulación con otras políticas públicas locales. Con base en este análisis, se reflexiona, finalmente, acerca de la imagen urbana, del perfil comercial y de las prácticas sociales promovidas, así como de sus alcances y limitaciones frente a las diferentes formas y procesos de la centralidad metropolitana, y la capacidad de vinculación con otras políticas urbanas de escala territorial.
Expansión de la ciudad en la zona metropolitana de Pachuca: procesos desiguales y sujetos migrantes e inmobiliarios
Authors: Pérez Marcial César Raúl 
Published: February 2018

La expansión de la ciudad de Pachuca a la zona metropolitana tiene, por un lado, a inmobiliarias que influyen desde los años ochenta con una oferta de viviendas encima del promedio nacional, sin una demanda real; y, por el otro, a los migrantes indígenas que con precariedad participan de la ampliación de la ciudad. Con una importante distinción entre ambos aspectos, este artículo busca identificar los componentes diferenciales de los actores de la expansión urbana de la ciudad y su expresión inicial en las zonas que ocupan, por lo que es importante definir la actuación institucional que responde a ciertas directrices y a la migración a condiciones estructurales, pues ambas generan una nueva visión del contexto urbano. A partir de posiciones teóricas, y por medio de mediciones funcionales a través de índices de urbanización en el orden estatal y regional, de marginación, de vulnerabilidad y de migración interna, se tiene como resultado la expresión de una estructuración sintética de la zona metropolitana de Pachuca (en adelante, zmp), donde las instituciones e inmobiliarias han creado una imagen idílica de la ciudad y los migrantes han generado zonas de la ciudad en condiciones fortuitas y de amplia fragilidad. Estas situaciones hacen que el proceso de metropolización en Pachuca sea intermitente, dependiente, fragmentado e incompleto.
Análisis de trade-off en el borde de una reserva forestal en el gradiente urbano-rural de Bogotá
Authors: Corrales Roa Elcy , Osorno Acosta Viviana 
Published: February 2018

El sistema socio ecológico (en adelante, sse) de la microcuenca de la quebrada San Cristóbal se encuentra localizado en el borde urbano rural de la localidad de Usaquén y la Reserva Forestal de los Cerros Orientales (Bogotá). Este sse ha sido transformado por el fenómeno de crecimiento urbano, lo cual ha generado cambios en el uso del suelo y en la degradación ambiental del ecosistema, y ha afectado la biodiversidad y el servicio ecosistémico (en adelante, se) de aprovisionamiento hídrico. Las decisiones o intervenciones humanas generan compromisos o tradeoff espaciales, temporales y sociales, que se analizan para el caso mencionado. La identificación y posterior análisis de estos trade-offs se hace a partir de diversas fuentes y consultas con diferentes actores. De esta manera se identifican los momentos clave que propiciaron la transformación del ecosistema, los efectos sobre el servicio ecosistémico a diferentes escalas espaciales y el balance de actores sociales que ganan o pierden en el proceso. Finalmente, a partir de las lecciones aprendidas, se encuentran variables y actores sociales clave, posibles escenarios y gestiones orientadas a la conservación o mejoramiento del se.
El arrendamiento residencial en los barrios populares: las redes de relaciones y la generación de compromisos
Authors: Sáenz Acosta Hernando 
Published: February 2018

El siguiente documento presenta un análisis del mercado de vivienda en arrendamiento en un barrio popular de la ciudad de Bogotá, y hace énfasis en los compromisos que se celebran entre arrendatarios y arrendadores. Para ello se presenta en un primer momento la metodología empleada en un trabajo de campo realizado entre el 2011 y el 2014 en el barrio Patio Bonito I, localizado al suroccidente de la ciudad. A partir de la Escuela de Convenciones Francesa como referente teórico, se exploran dos aspectos importantes para el funcionamiento de este mercado residencial: la existencia de redes de relaciones y la celebración de compromisos entre los agentes económicos. Estas características son cruciales para desarrollar una lectura institucional heterodoxa de este tipo de mercado —centrada en el concepto de las convenciones sociales— y comprender así las formas creadas por las comunidades en los barrios populares de la ciudad para su regulación.
A New Unbiased Stochastic Derivative Estimator for Discontinuous Sample Performances with Structural Parameters
Authors: Peng Yijie , Fu Michael C. , Hu Jian-Qiang , Heidergott Bernd 
Published: February 2018

In this paper, we propose a new unbiased stochastic derivative estimator in a framework that can handle discontinuous sample performances with structural parameters. This work extends the three most popular unbiased stochastic derivative estimators: (1) infinitesimal perturbation analysis (IPA), (2) the likelihood ratio (LR) method, and (3) the weak derivative method, to a setting where they did not previously apply. Examples in probability constraints, control charts, and financial derivatives demonstrate the broad applicability of the proposed framework. The new estimator preserves the single-run efficiency of the classic IPA-LR estimators in applications, which is substantiated by numerical experiments. The online appendix is available at https://doi.org/10.1287/opre.2017.1674 .
Pulsed electromagnetic field stimulation may improve fusion rates in cervical arthrodesis in high-risk populations
Authors: Coric D. , Bullard D. E. , Patel V. V. , Ryaby J. T. , Atkinson B. L. , He D. , Guyer R. D. 
Published: February 2018

Objectives Pulsed electromagnetic field (PEMF) stimulation was evaluated after anterior cervical discectomy and fusion (ACDF) procedures in a randomized, controlled clinical study performed for United States Food and Drug Administration (FDA) approval. PEMF significantly increased fusion rates at six months, but 12-month fusion outcomes for subjects at elevated risk for pseudoarthrosis were not thoroughly reported. The objective of the current study was to evaluate the effect of PEMF treatment on subjects at increased risk for pseudoarthrosis after ACDF procedures. Methods Two evaluations were performed that compared fusion rates between PEMF stimulation and a historical control (160 subjects) from the FDA investigational device exemption (IDE) study: a post hoc (PH) analysis of high-risk subjects from the FDA study (PH PEMF); and a multicentre, open-label (OL) study consisting of 274 subjects treated with PEMF (OL PEMF). Fisher’s exact test and multivariate logistic regression was used to compare fusion rates between PEMF-treated subjects and historical controls. Results In separate comparisons of PH PEMF and OL PEMF groups to the historical control group, PEMF treatment significantly (p < 0.05, Fisher’s exact test) increased the fusion rate at six and 12 months for certain high-risk subjects who had at least one clinical risk factor of being elderly, a nicotine user, osteoporotic, or diabetic; and for those with at least one clinical risk factor and who received at least a two- or three-level arthrodesis. Conclusion Adjunctive PEMF treatment can be recommended for patients who are at high risk for pseudoarthrosis. Cite this article: D. Coric, D. E. Bullard, V. V. Patel, J. T. Ryaby, B. L. Atkinson, D. He, R. D. Guyer. Pulsed electromagnetic field stimulation may improve fusion rates in cervical arthrodesis in high-risk populations. Bone Joint Res 2018;7:124–130. DOI: 10.1302/2046-3758.72.BJR-2017-0221.R1.
The phenomenology of Angry Birds: Virtual gravity and distributed proprioception in video game worlds
Authors: Giddings Seth 
Published: February 2018

Abstract
This article explores the nature of sensation, perception and proprioception in contemporary digital and mobile culture, as exemplified in digital games. It argues that the application of theories of the phenomenology of perception to digital media and games needs to be extended and adapted to acknowledge and describe the sensing and proprioceptive abilities of technological bodies (both hardware and software) as well as human bodies. The article explores the idea that the embodied ‘feeling’ (proprioception) of virtual physics, particularly gravity, in gameplay experience must be understood as distributed across and through human and non-human sensing bodies. It will take the popular mobile game Angry Birds as a starting point, but will then explore the achievement of distributed proprioception in other games and games hardware more broadly.
Blood hormones, metabolic parameters and fatty acid proportion in dairy cows fed condensed tannins and oils blend
Authors: Szczechowiak Joanna , Szkudelska Katarzyna , Szumacher-Strabel Małgorzata , Sadkowski Sławomir , Gwozdz Kinga , El-Sherbiny Mohamed , Kozłowska Martyna , Rodriguez Victor , Cieslak Adam 
Published: February 2018

Abstract
The aim of this study was to track the changes in blood parameters of mid-lactation multiparous Polish Holstein-Friesian cows in response to a diet supplemented with a mixture of fish-soybean oils blend and tannin-containing lingonberry shrub (Vaccinium vitis idaea; VVI) extract. Twelve lactating cows were randomly assigned to a crossover design of two treatments (6 cows per treatment) which consisted of a control diet containing no supplement (CON) and CON supplemented with a mixture of 99 g of VVI leaves extract and 660 g of blended fish-soybean oils (MIX) daily. The obtained results showed a significant increase in plasma glucose level, as well as C18:1t11 and n-3 fatty acids proportion. A significant decrease was also observed in insulin concentration, triglyceride and C18:0 proportion. Generally, the saturated fatty acid proportion decreased while the unsaturated fatty acid significantly increased with the MIX diet. In conclusion, using supplements of a mixture of VVI extract and fish-soybean oils blend modulated the unsaturated fatty acid proportion in blood, without affecting the dairy cows’ blood parameters which were all within the normal ranges.
Comparison of network processes between successful and unsuccessful offensive sequences in elite soccer
Authors: Peixoto Diogo , Praça Gibson Moreira , Bredt Sarah , Clemente Filipe Manuel 
Published: February 2018

AbstractPurpose. The study aimed to compare social network analysis (SNA) general measures and centrality levels of successful and unsuccessful offensive sequences performed by elite national teams in 64 matches of the FIFA World Cup 2014 tournament and to compare the level of centrality between playing positions. Methods. Adjacency matrices of passing sequences within an offensive unit were built and treated in a dedicated SNA software. Results. The main results indicated significantly lower values of total links and network density in successful sequences in comparison with unsuccessful ones in the teams that achieved the round of 8, semifinals, and the final. The comparisons between playing positions revealed that forwards showed the highest values of indegree centrality (balls received) and that midfielders presented the highest values of outdegree centrality (ball passed) in both successful and unsuccessful offensive units. Midfielders also exhibited the highest values of betweenness centrality (intermediation between teammates) in unsuccessful sequences and forwards in successful ones. Conclusions. Greater cooperation among teammates may not be determinant for successful sequences. Forwards are the prominent players to receive the ball and intermediate the passing sequence in offenses that end in a goal.
Convergence of explicitly coupled simulation tools (co-simulations)
Authors: Moshagen Thilo 
Published: February 2018

Abstract
In engineering, it is a common desire to couple existing simulation tools together into one big system by passing information from subsystems as parameters into the subsystems under influence. As executed at fixed time points, this data exchange gives the global method a strong explicit component. Globally, such an explicit co-simulation schemes exchange time step can be seen as a step of an one-step method which is explicit in some solution components. Exploiting this structure, we give a convergence proof for such schemes. As flows of conserved quantities are passed across subsystem boundaries, it is not ensured that system-wide balances are fulfilled: the system is not solved as one single equation system. These balance errors can accumulate and make simulation results inaccurate. Use of higher-order extrapolation in exchanged data can reduce this problem but cannot solve it. The remaining balance error has been handled in past work by recontributing it to the input signal in next coupling time step, a technique labeled balance correction methods. Convergence for that method is proven. Further, the lack of stability for co-simulation schemes with and without balance correction is stated.
Interprofessionelle Ausbildung für die Gesundheitsversorgung von morgen – eine Schweizer Perspektive
Authors: Kaap-Fröhlich Sylvia 
Published: February 2018

ZusammenfassungDer Beitrag skizziert den aktuellen Stand der interprofessionellen Ausbildung in der Schweiz. Er beschreibt die derzeit günstigen gesundheitspolitischen Rahmenbedingungen und zeigt mögliche Entwicklungen anhand von Zielgruppen, Inhalten und Methoden auf. Im Mittelpunkt aller interprofessionellen Ausbildungsbemühungen steht die patientenzentrierte Gesundheitsversorgung.