bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entwicklung eines vorläufigen Best Practice Modells für
stationsäquivalente psychiatrische Behandlung aus Sicht von Nutzer*innen:
Konsensprozess mit partizipativen Anteilen
Authors: Schwarz Julian , Scheunemann Kim , Mundry Hannah , Kula Emma , Randzio Nadine , Salzmann Marie , Längle Gerhard , Raschmann Svenja , Holzke Martin , Brieger Peter , Hamann Johannes , Hardt Olaf , Rout Sandeep , Hirschmeier Constance , Herwig Uwe , Senner Simon , Richter Janina , Timm Jürgen , Kilian Reinhold , Nikolaidis Konstantinos , Weinmann Stefan , Bechdolf Andreas , von Peter Sebastian 
Published: October 2024

Zusammenfassung
Ziel Die stationsäquivalente Behandlung (StäB) ist neuartig in Deutschland
und bedarf daher einer Qualitätsentwicklung. Es wird ein Best Practice Modell
(BPM) für StäB aus Sicht von Nutzer*innen erarbeitet.
Methodik 1. Sammeln und Ordnen der Evidenz zu Qualitätskriterien
(Literaturrecherche; n=55 Interviews), 2. Qualitative Inhaltsanalyse und
Formulierung von Kriterien; 3. Konsentierung und Gruppierung der Kriterien
(modifiziertes Delphi-Verfahren).
Ergebnisse Es wurden 58 Best Practice Kriterien in 8 Gruppen entwickelt:
1. Information, Zugang und Krisenmanagement; 2. Rahmen der Behandlung,
Behandlungsende und Kontinuität; 3. Terminplanung, Organisation der Kontakte und
Flexibilität; 4. Praktische Unterstützung und Aktivierung; 5. Behandlungs- und
Therapieangebote; 6. Behandlungsteam und Mitarbeiter*innen; 7. Angehörige,
Bezugspersonen und Community und 8. Privatsphäre und Verhalten im häuslichen
Umfeld.
Schlussfolgerung Das BPM gibt erste Hinweise für eine
nutzer*innenfokussierte Überprüfung der Umsetzung von StäB.
Consensus Statement on the Outcome of the European Herbal Health Products Summit – Which Way Forward?
Authors: Heinrich Michael , Reiken Babette , Roether Bernd , Müller Angela , Rumsch Julia , Symma Nico 
Published: October 2024

AbstractHerbal medicinal products are a vital part of the healthcare system in Europe and beyond. Being predominantly sold as non-prescription medicines in pharmacies, they are very popular with patients, physicians, and pharmacists and are therefore an important part of self-medication. Interest in this sector has recently gained momentum, reflecting the ongoing revision of the general pharmaceutical legislation and the recent discussion on nutrition and health claims on foods based on the implementation report of Regulation (EC) No 1924/2006 by the European Parliament 1. Therefore, on 20th February 2024, the Society for Medicinal Plant and Natural Product Research (GA), in collaboration with the German Pharmaceutical Industry Association (BPI) and the German Medicines Manufacturersʼ Association (BAH, now Pharma Deutschland), hosted an in-person summit in Brussels entitled ‘European Herbal Health Products Summit – Which way forward?ʼ. The summit
featured a wide range of speakers, including policymakers, regulatory authorities, industry representatives, and academic experts. It was divided into several sessions covering topics such as the future and relevance of herbal medicinal products in the EU, the revision of the EU pharmaceutical legislation, and the resulting impact on herbal medicinal products. Furthermore, the discussions delved into the “Health Claims Regulation” – the European Parliamentʼs implementation report and the related regulatory challenges of herbal medicinal products at an EU level. This consensus paper summarises the current status and provided recommendations to pave the way for future strategies to ascertain the continued use of herbal medicinal products as an important therapeutic option for patients.
Glucagon-like peptide-1 receptor agonists significantly affect the quality of bowel preparation for colonoscopy
Authors: Abu-Freha Naim , Yitzhak Avraham , Shirin Haim , Nevo-Shor Anat , Abu-Jaffar Jafar , Abu-Rafe Samer , Afianish Yaser , Cohen Daniel L. , Bermont Anton 
Published: October 2024

Abstract
Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) affect gastrointestinal motility, slowing gastric emptying and colonic transit. GLP-1RAs have an impact on gastric residue before endoscopy, but only limited data are available regarding its effect on the adequacy of colonic preparation. We investigated the association between GLP-1RA use and inadequate bowel preparation (IBP) for colonoscopy.
Methods We performed a multicenter retrospective study with GLP-1RA cases matched with controls (using propensity scores for age, sex, diabetes mellitus [DM], obesity, and co-morbidities). Data on demographics, medication use, procedural indications, and colonoscopy findings were collected. IBP (“poor preparation” on Aronchik scale or Boston Bowel preparation scale <5) was the primary outcome.
Results 4876 patients treated with GLP-1RAs were included in the analysis and compared with 4876 controls selected from 333 648 patients without GLP-1RA use. Among the GLP-1RA patients, 10% (n = 487) had IBP compared with 197 (4%) of the control group (P<0.001). Subgroup analysis showed a higher rate of IBP among diabetic patients treated with GLP-1RA (284/2364 [12%]) than among diabetic patients without GLP-1RA treatment (118/2364 [5%]; P<0.001). Additionally, 203/2512 nondiabetic patients treated with GLP-1RAs had IBP (8%) compared with 79 of the nondiabetic non-GLP-1RA group (3%; P<0.001). On multivariate analysis, diabetes and GLP-1RA use were both found to be independent risk factors for IBP (odds ratio [OR] 1.4 and OR 2.7, respectively; both P<0.001).
Conclusion Our findings highlight the necessity for special attention and tailored recommendations for both diabetic and nondiabetic patients treated with GLP-1RAs in terms of colonic preparation prior to colonoscopy.
Taking a Team Approach: Keep Up with the EHR with a Training and Optimization Program
Authors: McEntee Rachel K. , Hitt Juvena R. , Sieja Amber 
Published: October 2024

Abstract
Objectives This study aimed to describe the current landscape of electronic health record (EHR) training and optimization programs (ETOPs) and their impact on health care workers' (HCWs) experience with the EHR.
Methods A 72-question electronic survey was developed and distributed to health care organization (HCO) leaders in clinical informatics (Chief Medical Information Officer [CMIO]/Chief Nursing Information Officer [CNIO]/Medical Informatics Executive, Associate CMIO/Medical Director of, Clinical/Nurse/Physician Informaticist) through various channels such as national informatics conferences, social media, and email distribution lists of vendors and informatics associations. The survey collected data on the characteristics, resourcing, approach, and outcomes of ETOPs. Descriptive statistics were applied to analyze the data.
Results There were 193 responses from 147 distinct HCOs. Of these, 69% offer ongoing EHR training, and 52% offer some version of an ETOP. Offered ETOPs vary in their timing, modality, audience, team composition, duration, and EHR build strategy. The most commonly measured outcomes were EHR satisfaction, efficiency, and provider burnout, and most ETOPs reported improvement in these areas.
Conclusion The findings suggest that ETOPs are inconsistently implemented across HCOs, and while there are some commonalities, there is a wide variety of designs and methods of evaluation for the programs. Though the problems to solve (EHR efficiency, proficiency, and satisfaction) are the same, the organizational structure and culture of HCOs vary widely, which may partially explain the variability seen in reported ETOPs. When considering the measured outcomes, ETOPs may have direct and indirect effects on HCW burnout by improving EHR efficiency and satisfaction, as well as driving organizational culture toward teamwork and flexible problem-solving. For this reason, ETOPs may also serve as a model for addressing other challenges in health care delivery. ETOPs are a promising intervention to enhance HCW experience with the EHR and reduce burnout. More research is needed to identify the optimal features, methods, and outcomes of ETOPs, and to disseminate them across HCOs.
Effect of Listening Music on Nulliparous Singleton Pregnancies Who Underwent Induction of Labor: A Randomized Clinical Trial
Authors: Saccone Gabriele , Malferà Maria Chiara , D'Antonio Lucia , Gallo Pasquale , Ammendola Alessandra , Buonomo Giorgia , Colacurci Dario , Zapparella Rosanna , Locci Mariavittoria 
Published: October 2024

Objective A recent randomized clinical trial (RCT) showed that listening to music reduces the pain level and anxiety levels in women with spontaneous labor at term. The effect on pregnant women undergoing induction of labor is still unclear.This study aimed to test the hypothesis that in nulliparous women with singleton pregnancies, undergoing induction of labor at term, listening to music would reduce the pain level during labor.
Study Design Parallel group, non-blinded, RCT conducted at a single center in Italy. Nulliparous women with singleton pregnancies and vertex presentation, admitted for induction of labor with either oral or vaginal prostaglandins, between 370/7 and 420/7 weeks, were randomized in a 1:1 ratio to receive music during induction of labor or no music during induction. The endpoints of the trials were the pain level during induction, and in the active phase of labor, recorded using the visual analog scale for pain, ranging from 0 (no pain) to 10 (unbearable pain). The effect of music use on each outcome was quantified as the mean difference (MD) with a 95% confidence interval (CI).
Results During the study period, 30 women agreed to take part in the study, underwent randomization, and were enrolled and followed up. Fifteen women were randomized in the music group and 15 in the control group. No patients were lost to follow-up for the primary outcome. Pain level during the induction procedure was 8.8 ± 0.9 in the music group, and 9.8 ± 0.3 in the control group (MD −2.60 points, 95% CI −3.94 to −1.26; p < 0.01). Music during labor and delivery was also associated with decreased anxiety during the induction procedure (MD −3.80 points, 95% CI −5.53 to −2.07; p < 0.01).
Conclusion In nulliparous women, listening to music during the induction of labor reduces pain and anxiety levels.
Key Points
Auricular Reconstruction
Authors: Kurian Keerthi E. , Oyer Samuel L. , Park Stephen S. 
Published: October 2024

AbstractThe auricle is susceptible to various injuries due to its location and projection from the scalp. The unique contours of the external ear makes reconstruction a challenging endeavor. This chapter provides a comprehensive overview of auricular reconstruction, based on the depth, location, and size of injury. Strategies for reconstructing superficial, composite, and full-thickness injuries are discussed in relation to the location of the defect. Targeted reconstructive options for injuries of the upper, middle, and lower thirds of the auricle are outlined. Methods for total auricular reconstruction and auricular prosthesis are discussed. Options for managing traumatic injuries are reviewed, including avulsion/amputation injuries, burns, electrical injuries, frostbite, and human/animal bites. This chapter provides a practical framework for surgeons faced with complex auricular defects, offering insights to recreate a discreet, harmonious ear.
Datennutzung für eine bessere Gesundheitsversorgung–Plädoyer für eine
kooperative Forschungsdatenplattform der gesetzlichen und privaten
Krankenversicherung und dem Netzwerk Universitätsmedizin (NUM)
Authors: Schmitt Jochen , Ihle Peter , Schoffer Olaf , Reese Jens-Peter , Ortmann Steffen , Swart Enno , Hanß Sabine , Hoffmann Falk , Stallmann Christoph , Kraus Monika , Semler Sebastian Claudius , Heyder Ralf , Vehreschild Jörg Janne , Heuschmann Peter , Krefting Dagmar , Sedlmayr Martin , Hoffmann Wolfgang ,   und die gemeinsame Arbeitsgruppe „Externe Daten“ des Netzwerks
                        Universitätsmedizin (NUM) und der Medizininformatik-Initiative*
Published: October 2024

ZusammenfassungDas BMBF fördert mit dem Netzwerk Universitätsmedizin (NUM) und der
Medizininformatik-Initiative (MII) zwei richtungsweisende strukturbildende
Forschungsmaßnahmen, die nun zusammengeführt werden. Die
Datenintegrationszentren (DIZ) der MII sollen im NUM verstetigt werden. Ziel ist
der Aufbau einer einheitlichen Dateninfrastruktur, innerhalb der die vorhandenen
Daten aus der klinischen Routineversorgung der 36 deutschen Universitätskliniken
des NUM, aus klinischen Kohorten und klinisch-epidemiologischen Studien auf
Antrag und über abgestimmte Prozesse für unterschiedliche Forschungsfragen
genutzt werden können. Rechtsgrundlage bildet hierfür der mit Ethikkommissionen
und Datenschutzbehörden abgestimmte und in allen NUM-Standorten implementierte
„Broad Consent“ der Universitätsmedizin mit einem so genannten „Kassenmodul“,
das die Erhebung und Verlinkung von medizinischen Routinedaten der gesetzlichen
Krankenversicherung (GKV) und der privaten Krankenversicherungen (PKV) als eine
Kategorie versorgungsnaher Daten (VeDa) erlaubt. Die Verknüpfung dieser
Routinedaten mit Daten aus Klinikinformationssystemen bietet ein besonders hohes
Potenzial, da keine Datenquelle allein ein vollständiges Bild der medizinischen
Versorgung zeichnet und sich die beiden Datenquellen ideal komplementär
ergänzen. Ziel ist es nun, in einer strategischen Partnerschaft mit gesetzlichen
Krankenkassen und privaten Krankenversicherungen diese Routinedaten in die
sichere, transparente und partizipative Forschungsinfrastruktur des NUM zu
integrieren. Dies fördert den Forschungsstandort Deutschland und trägt
entscheidend dazu bei, die Qualität und Sicherheit der Gesundheitsversorgung in
Deutschland evidenzbasiert zu verbessern.
Visible-Light-Induced Photoredox Construction of Trifluoromethylated Quaternary All-Carbon Centers and Tertiary Alcohols via C(sp3)–Si Bond Cleavage
Authors: Bai Dachang , Ma Dandan , Chang Lingna , Cai Yue 
Published: October 2024

AbstractThe construction of trifluoromethylated quaternary carbon centers and tertiary alcohols is realized by organo-photoredox catalysis. The process proceeds via visible-light-induced C(sp3)–Si bond cleavage for the generation of α-trifluoromethylated benzyl radicals, which are readily trapped by electron-deficient alkenes with excellent regioselectivity for the construction of trifluoromethylated quaternary all-carbon centers. The α-difluoromethyl counterparts are also suitable for this radical conjugate addition. Furthermore, the in situ oxidation of these α-trifluoromethylated radicals with O2 from air affords tertiary alcohols in high yields, which extends the Fleming–Tamao reaction to tertiary carbon systems.
Three-Component Syntheses of Functionalized Selenocyanates
Authors: Ostapiuk Yurii V. , Schmidt Andreas , Barabash Oksana V. , Ostapiuk Mary Y. , Herzberger Colin , Plieth Mattes 
Published: October 2024

AbstractA metal-free Meerwein-type arylation protocol of α,β-unsaturated compounds is reported. 4-Aryl-3-selenocyanatobutan-2-ones, methyl 3-aryl-2-selenocyanatopropanoates, 3-aryl-2-selenocyanatopropanenitriles, and 1-aryl-2-phenyl-2-selenocyanatoethanes were prepared by a selenocyanatoarylation reaction from easily available arenediazonium tetrafluoroborates, potassium selenocyanate, and methyl vinyl ketone, methyl acrylate, acrylonitrile, or styrene, respectively, in 39–84% yields. The reaction proceeds smoothly and quickly under mild reaction conditions. The reaction can be scaled to the gram scale. A mechanism for this reaction is proposed.
Desmoplastic Small Round Cell Tumor of the Spinal Canal: A Rare Presentation in a Female Pediatric Patient
Authors: Ahuja Sana , Malik Shaivy , Yadav Vivek , Ahluwalia Charanjeet 
Published: October 2024

AbstractDesmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy primarily affecting young individuals, typically originating in the abdominal cavity. While spinal involvement by DSRCT is exceedingly rare, especially in pediatric patients, recognizing such atypical presentations is crucial for optimal management. Here, we present a case of DSRCT involving the spinal canal in a 3-year-old female child, representing one of the youngest documented instances in the literature. Initial symptoms included weakness, lower limb pain, and urinary incontinence. Magnetic resonance imaging revealed an enhancing soft tissue lesion in the spinal canal, prompting tumor excision and histopathological examination. The tumor exhibited characteristic features of DSRCT, including small round cells within a desmoplastic stroma. Immunohistochemistry confirmed the diagnosis, showing positivity for Wilms tumor 1, epithelial membrane antigen, desmin, and synaptophysin. This case highlights the challenges in diagnosing and managing rare tumors like spinal DSRCT, emphasizing the importance of a comprehensive approach to differential diagnosis and individualized treatment strategies.
Structural Alterations in Diverticular Disease
Authors: Lopez Kerri , Maguire Lillias H. 
Published: October 2024

AbstractClinicians appreciate the structural alterations of diverticular disease when navigating narrow, angulated colons with a colonoscope or removing stiff, fixed sigmoid colons at surgery. Investigation of these tissues reveals increased thickness of smooth muscle, alterations in the amount and structure of the extracellular matrix, and changes to the motility of the colon. More sophisticated technologies now allow scientists to unravel the connections between these alterations and the individual genetic background. This article explores the structural alterations of diverticular disease including collagen, smooth muscle, the enteric nervous system, and the interstitial cells of Cajal.
A Case of Giant Extracalvarial Epidermal Cyst with Intracranial Extension
Authors: Bhasme Vishal , Jain Divya 
Published: October 2024

AbstractExtracalvarial epidermal cysts are benign, uncommon type of tumors. Their incidence is around 0.2 to 1%. They are usually asymptomatic except for the absurd swelling over the scalp, which is associated with headache and rarely neurological deficits. Proper radiological diagnosis with accurate surgical approach and excision with capsule gives a good prognosis and prevents recurrence. Here we present the case of a 75-year-old gentleman with a large swelling over the scalp with mild pain. Surgical excision of the tumor with capsule was done followed by cranioplasty. The histopathology was consistent with an epidermal cyst. Case reports pertaining to such conditions are few.
Neuroendoscopy Training
Authors: Hedaoo Ketan , Sinha Mallika , Chauhan Bhanu Pratap Singh , Bajaj Jitin , Ratre Shailendra , Swamy M.N. , Parihar Vijay , Shakya Jitendra , Sharma Mukesh , Patidar Jayant , Yadav Yad Ram 
Published: October 2024

AbstractNeuroendoscopy can be learnt by assisting or doing live human surgery, cadaver dissection with or without augmented pulsatile vessel and cerebrospinal fluid (CSF) perfusion, and practicing on live animal, dead animal model, synthetic models, three-dimensional printing model with or without augmentation with animal, cadaver tissue, pulsatile vessel and reconstructed CSF model, virtual reality (VR) simulator, and hybrid simulators (combined physical model and VR model). Neurosurgery skill laboratory with basic and advanced learning should be there in all teaching hospitals. Skills can be transferred from simulation model or VR to cadaver to live surgery. Staged learning (first with simple model to learn basic endoscopic technique, then animal model, and then augmented cadavers) is the preferred method of learning. Although most surveys favor live surgery and practice on animal models and cadavers as the most preferred training model now, in future VR may also become a favored method of learning. This article is based on our experience in over 10,000 neuroendoscopic surgeries, and feedback from over 950 neuroendoscopic fellows or consultants who attended workshops conducted every 6 monthly since 2010. A literature search was done on PubMed and Google Scholar using (neuroendoscopy) AND (learning), and (neuroendoscopy) AND (training), which resulted in 121 and 213 results, respectively. Out of them, 77 articles were finally selected for this article. Most of the training programs typically focus on microneurosurgical training. There is lack of learning facilities for neuroendoscopy in most centers. Learning of neuroendoscopy differs greatly from microneurosurgery; switching from microneurosurgery to neuroendoscopy can be challenging. Postgraduate training centers should have well-equipped neuroendoscopy skill laboratory and the surgical educational curriculum should include neuroendoscopy training. Learning endoscopy is about taking advantages of the technique and overcoming the limitations of endoscopy by continuous training.
An effective approach for correlating Na+ concentrations with sweating rates in wearable sweat sensing platform
Authors: He Anwei , Wang Xiaohe , Zhang Liang , Zhang Haolong , Xu Xingli , Yu Chenyang , Ma Yongquan , Wei Wei , Niu Pengfei 
Published: October 2024

Accurately correlating the sweating rate and the concentration of biomarkers in sweat is essential in many sweat-based diagnostic applications. These two measurements are always done simultaneously in wearable sweat sensing platforms. However, concentration measurements of biomarkers are always delayed on the timeline compared with their production, whereas there is no such delay for sweating rate. Thus, a timeline mismatch exists between these two measurements. This means that the concentration vs rate correlation constructed on the basis of such measurements will deviate from the actual correlation. This study demonstrates the existence of this mismatch and explains its cause using sweat Na+ measurements. It also proposes an effective approach that applies a point-by-point compensation for the delay between Na+ measurements and the real-time sweating rates, such that the data on the repositioned concentration vs time curve correspond to exactly the same point on the timeline as their production. A vison sensor is developed to measure the sweating rate with high accuracy at a frequency of more than 0.1 Hz. Off-body and on-body measurements of sweating rate and Na+ concentration are carried out, and concentration–rate correlations are constructed using both measured and repositioned concentration curves. The least squares and random forest methods are employed to fit the constructed correlations and evaluate the reliability of the proposed approach. The use of the repositioned concentration curve gives a constructed correlation that is much closer to the actual one. This study indicates the necessity to rearrange sensor-measured biomarker concentration vs time curves when correlations of concentration with sweating rate need to be constructed and proposes a practical point-by-point data repositioning strategy for doing so. The results presented here will benefit the study of sweat biomarkers with unclear correlations with sweating rate, as well as providing a basis for the development of more reliable sweat-based diagnostic methods.