bluuebunny/crossref_metadata_2025_split huggingface dataset:
PAROKSIZMALNA NOČNA HEMOGLOBINURIJA - PRIPOROČILA ZA ODKRIVANJE BOLEZNI TER PREGLED POPULACIJE BOLNIKOV V SLOVENIJI
Authors: Hauptman Jasmina , Žontar Darja , Preložnik Zupan Irena 
Published: November 2017

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease associated with hemolytic anemia, bone marrow failure, thrombosis, and, frequently, poor quality of life. It is caused by defects in the membrane of blood cells, where there is a lack of protein on the cell surface, which inhibits complement activation. We wanted to know the recognition of the disease in Slovenia and the incidence. We prepared the recommendations for discovering of the disease. Patients and methods: We collected data of 68 patients with prospective analysis of one – year period from 1.10.2013 to 30.9.2014 whose blood was sent to the laboratory of immunology and cytology because of suspected presence of PNH clone. The analysis of peripheral blood was performed with multiparametric high specific flow cytometry in a specialized laboratory KO of Haematology University Medical Centre in Ljubljana. Results: PNH clone was positive in 13/68 (19%) patients, 55/68 (81%) patients had a negative PNH clone, most positive samples were sent from the University Medical Centre Ljubljana (7/13). 4/13 positive patients were newly discovered. In average the incidence through 10-years was 1,3 / 1,000,000 population/year. The most common cause of PNH patient referral to a specialist hematologist was unexplained cytopenia - 12/13 (92.3%), the most common symptoms were fatigue and dyspnea (100%), in 2/13 patients was present dark urine with hemoglobinuria, 2/13 patients had transient renal insufficiency. 11/13 patients with positive PNH clone had associated a bone marrow failure (aplastic anemia or myelodysplastic syndrome). The size of PNH clone varied from patient to patient. Conclusions: Early identification of PNH is a key to effective treatment and survival of patients. We recommend determining PNH clone at Coombs negative hemolytic anemia, hemoglobinuria, an unexplained cytopenia, aplastic anemia, myelodysplastic syndrome with laboratory evidence of haemolysis and unexplained thrombosis.
Uporaba zdravil in dojenje v poporodnem obdobju v Sloveniji
Authors: Krajec Maja , Natek Neva , Geršak Ksenija 
Published: November 2017

Background: To date there are no known data about the use and administration of medicine in the postpartum period in Slovenia.Methods: We included 1,070 women after they gave birth in a prospective cross-sectional study while they were routinely admitted to the Maternal and Neonatal Unit of the Department of Perinatology at the University Medical Centre Ljubljana’s, from October 2011 to February 2012. Data were collected through written questionnaires and finally statistically analysed. The same questionnaires were given at time points of 3, 6, and 12 months after giving birth.Results: Three days after giving birth 96.5% of women were breastfeeding fully or partially. The most commonly used medications during this period were analgetics, laxatives and iron supplements. In the period of up to 3 months after giving birth, 84.0% of women were breastfeeding fully or partially, whereas the number decreased to 72.4% in the period from 3 to 6 months after giving birth. Analgetics, vitamins and/or minerals and folic acid supplements were the most used medications in both periods. From 6 to 12 months after giving birth 51.5% of women were breastfeeding. Vaginally administered antimycotics were most commonly used medicines in this time period in addition to analgetics, vitamins and/or mineral supplements.Conclusions: No significant difference could be determined in the frequency of medicine use in all three time periods after giving birth between both groups of breastfeeding and non-breastfeeding mothers. Moreover, no difference could be observed in the frequency of medicine use between the fully and partially breastfeeding mothers. This study has also shown that the most frequent used medicinal substances were folic acid, vitamins and/or minerals, analgetics, and antimycotics in the form of vaginal tablets.
Priporočila za odkrivanje in zdravljenje periferne arterijske bolezni
Authors: Blinc Aleš , Kozak Matija , Šabovič Mišo , Boc Vinko , Poredoš Pavel , Flis Vojko , Breznik Silva , Ključevšek Tomaž , Kuhelj Dimitrij , Gasparini Mladen , Kerin Klemen , Žuran Ivan , Poklukar Janez , Valentinuzzi Vladimir , Klokočovnik Tomislav 
Published: November 2017

In the article, recommendations for the diagnostics in suspected peripheral arterial disease are presented together with therapeutic procedures and long- term follow up of the affected patients.
Le vieillissement des électeurs communistes à l’épreuve des vicissitudes du communisme municipal
Authors: Gouard David 
Published: November 2017

Le comportement électoral des anciens électeurs communistes au sein des quartiers populaires a souvent fait l’objet de controverses. Si une partie des recherches insistent sur la fidélité électorale qui continue de caractériser les générations ouvrières, d’autres recherches pointent au contraire la croissance de l’abstention et la progression du vote d’extrême-droite au sein de ces groupes sociaux. Cet article se donne précisément pour objectif d’interroger la diversité des trajectoires sociopolitiques des personnes âgées qui apportaient autrefois régulièrement leur soutien électoral en faveur des candidats communistes. Cette étude se fonde sur une enquête monographique et comparative de deux anciens quartiers ouvriéro-communistes de la région parisienne qui ont, depuis les années 80, connu des trajectoires sociales et politiques nettement contrastées. L’essentiel des matériaux d’enquête repose sur des questionnaires recueillis à la sortie des bureaux de vote, des entretiens et des observations. La comparaison des deux quartiers fait apparaître deux grands modèles de vieillissement. Dans le premier quartier, là où le fait communiste s’est largement émoussé, les populations âgées évoluent dans une forme d’anomie sociale et politique qui tend à nourrir la désaffiliation électorale à l’égard de l’ancien ordre politique local. À l’inverse, la revalorisation symbolique de l’autre quartier, là où les descendants de l’ancienne « aristocratie politique » locale se sont majoritairement installés, participe au maintien d’une cohésion intergénérationnelle et intragénérationnelle favorable à la fois à l’exercice de la citoyenneté à l’échelle locale, mais également au maintien d’une loyauté aux candidats communistes.
Time Complexity Analysis of the Binary Tree Roll Algorithm
Authors: Božinovski Adrijan , Tanev George , Stojčevska Biljana , Pačovski Veno , Ackovska Nevena 
Published: November 2017

This paper presents the time complexity analysis of the Binary Tree Roll algorithm. The time complexity is analyzed theoretically and the results are then confirmed empirically. The theoretical analysis consists of finding recurrence relations for the time complexity, and solving them using various methods. The empirical analysis consists of exhaustively testing all trees with given numbers of nodes and counting the minimum and maximum steps necessary to complete the roll algorithm. The time complexity is shown, both theoretically and empirically, to be linear in the best case and quadratic in the worst case, whereas its average case is shown to be dominantly linear for trees with a relatively small number of nodes and dominantly quadratic otherwise.
Organization of Laboratory for Monitoring Security in the Food Industry in Order to Detect the Presence of Allergens
Authors: Gojković Vesna , Beribaka Mirjana , Marjanović-Balaban Željka 
Published: November 2017

Allergens are substances that cause allergic reactions. Allergic reactions differ from person to person in a sensitive and specific response to the presence of the same allergen. Groceries that often cause allergies are cow’s milk, eggs, fish, crustaceans and shellfish, wheat, soy, peanuts, walnuts, almonds, hazelnuts and strawberries.Organisation is the main factor for the success and the quality of a research in food industry laboratories, in order to detect the presence of allergens. All kinds of equipments are needed, as well as professional staff to perform the tests. Allergen testing in the food industry is often performed using biochemical and separation methods. For analysis of deoxyribonucleic acid (DNA), the most suitable method is polymerase chain reaction (PCR) and electrophoresis. In our laboratory, we use immunological methods for qualitative and quantitative testing of allergens and we have two accredited methods: Enzyme-Linked Immunosorbent Assays (ELISA) and High Performance Liquid Chromatography (HPLC). It is also necessary that stuff have adequate competence in handling the specific equipment, performing tests, evaluating the results and signing test reports and calibration certificates, have adequate competences. Laboratory have to prove that have been fulfiled all the requirements for validation. Validation includes: specification of requirements, characterization of method, verification that requirements can be fulfilled using the method.The results of each test are presented in form of a report, which has to be correct, clear, unambiguous, objective and must include all the informations required by the client.
Everolimus for treatment of tuberous sclerosis complex‐associated neuropsychiatric disorders
Authors: Krueger Darcy A. , Sadhwani Anjali , Byars Anna W. , de Vries Petrus J. , Franz David N. , Whittemore Vicky H. , Filip‐Dhima Rajna , Murray Donna , Kapur Kush , Sahin Mustafa 
Published: November 2017

AbstractObjectiveTo evaluate if short‐term treatment with everolimus was safe and could improve neurocognition and behavior in children withTSC.MethodsThis was a prospective, double‐blind randomized, placebo‐controlled two‐center phaseIIstudy. Participants diagnosed withTSCand age 6–21 years were treated with 4.5 mg/m2per day of oral everolimus (n = 32) or matching placebo (n = 15) taken once daily for 6 months. For efficacy, a comprehensive neurocognitive and behavioral evaluation battery was performed at baseline, 3 months, and 6 months. For safety, adverse events recorded continuously via patient diary were categorized and graded perNCICommon Toxicity Criteria for Adverse Events, version 3.0 (CTCAE3.0). Analyses were performed on the intention‐to‐treat population (n = 47).ResultsNearly all assessment measures failed to demonstrate significant differences between the two groups at the end of 6 months. Only one measure each of executive function (Cambridge Neuropsychological Test Automated Battery Stockings of Cambridge) favoring placebo (P = 0.025) and social cognition (Social Responsiveness Scale Social Cognition Subscale) favoring everolimus (P = 0.011) was observed. A total of 473 adverse events (AE) were reported. The average number of totalAEper subject was similar for both placebo and everolimus. Most were mild or moderate in severity and seriousAEwere rare.InterpretationWhile safe, oral everolimus administered once daily for 6 months did not significantly improve neurocognitive functioning or behavior in children withTSC.
Effects of the electrolyte content on the electrical permittivity, thermal stability, and optical dispersion of poly(vinyl alcohol)–cesium copper oxide–lithium perchlorate nanocomposite solid‐polymer electrolytes
Authors: Al‐Gunaid Murad Q. A. , Saeed Adel M. N. , Siddaramaiah  
Published: November 2017

ABSTRACTSolid‐polymer electrolytes (SPEs) in the form of poly(vinyl alcohol) (PVA) doped with various amounts (5, 10, and 15 wt %) of lithium perchlorate trihydrate (LiClO4·3H2O) and 2 wt % cesium copper oxide (Cs2CuO2) nanoparticles were fabricated by a solvent intercalation method. The obtained nanocomposites were evaluated for their chemical structure and microstructural and morphological behaviors via Fourier transform infrared spectroscopy, X‐ray diffraction, and scanning electron microscopy methods, respectively. The obtained dielectric behaviors, alternating‐current conductivity, dielectric modulus, and dielectric relaxation of the SPEs depended on the volume fraction of the electrolyte. Linear behavior of the current–voltage characteristics for all of the SPE films was observed with a slight deviation at a higher voltage. The thermal behaviors of the PVA–Cs2CuO2–LiClO4 films were evaluated by differential scanning calorimetry and thermogravimetric analysis. The refractive index, band‐gap energy, and optical dispersion were examined with UV–visible spectroscopy. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45852.
The role of radical polymerization in the production of thermoregulating microcapsules or polymers from saturated and unsaturated fatty acids
Authors: Szczotok Anna M. , Carmona Manuel , Kjøniksen Anna‐Lena , Rodriguez Juan F. 
Published: November 2017

ABSTRACTThe microencapsulation of linoleic (LinA), oleic, erucic, and palmitic acids (PAs) from styrene and divinylbenzene were studied by using the suspension‐like polymerization technique. All materials exhibited a spherical shape, with a particle size between 166 and 416 μm. The phase change material (PCM) content decreased with the presence of double bonds in the fatty acid molecule. The thermal energy storage (TES) capacity of the microcapsules (MC) containing saturated PA was the highest (123.30 J g−1). Whereas, the lowest TES capacity was observed for the LinA. TES capacity values from unsaturated fatty acid materials and the high particle yield indicated that these kinds of acids played two different roles, as PCM and also as monomers, in the radical polymerization processes. At high initiator concentrations, the unsaturated fatty acids were observed to react. This was confirmed by Fourier transform infrared where the peak assigned to the CC bond disappears in the spectrum of MC. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45970.
Electroconductive and catalytic performance of polypyrrole/montmorillonite/silver composites synthesized through in situ oxidative polymerization
Authors: Tran Xuan Tin , Park Sung Soo , Hussain Manwar , Kim Hee Taik 
Published: November 2017

ABSTRACTThe present study demonstrates a simple approach to the formation of polypyrrole/montmorillonite/silver (PPy/Mt/Ag) composites via in situ oxidative polymerization of pyrrole (Py) in the presence of AgNO3 acting as a direct oxidant. The polymerization was performed in the presence of dodecylbenzenesulfonic acid, which acts as a stabilizing and doping agent. The morphological, structural, and thermal properties of PPy/Mt/Ag composites are discussed in detail and a possible formation mechanism is proposed. The electrical conductivities of the composites pressed at different pressing pressures were investigated using four‐probe analyzer. X‐ray diffraction, transmission electron microscopy, and scanning electron microscopy results indicated the partially exfoliated structure of the composites and Fourier transforms infrared results suggested the strong interactions between SiOSi groups in Mt and NH groups in PPy chains. The addition of Mt in the PPy polymer enhanced thermal property of the polymer. The conductivity of 1.08 S cm−1 was observed in the sample with 20 wt % Mt loading and applied pressure of 5 MPa. The composites obtained in the present study catalyze the reduction of methylene blue by sodium borohydride, achieving 92% conversion of MB to colorless within a few minutes. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45986.
Trajectories of resting frontal brain activity and psychopathology in female adolescents exposed to child maltreatment
Authors: Tang Alva , Miskovic Vladimir , Lahat Ayelet , Tanaka Masako , MacMillan Harriet , Van Lieshout Ryan J. , Schmidt Louis A. 
Published: November 2017

AbstractResting frontal electroencephalogram (EEG) alpha asymmetry patterns reflecting different affective and motivational tendencies have been proposed as a putative mechanism underlying resilience among maltreated youth. This 2‐year prospective study examined whether developmental stability of resting frontal alpha asymmetry moderated the relation between child maltreatment severity and psychopathology in female adolescents (n = 43; ages 12–16) recruited from child protection agencies. Results identified two trajectories of resting frontal asymmetry: 60.5% displayed stable right and 39.5% displayed stable left frontal alpha asymmetry. Although individuals with these alpha asymmetry profiles experienced comparable childhood trauma severity, adolescents with stable left alpha asymmetry and lower levels of trauma were less likely to present symptoms or an episode of posttraumatic stress disorder (PTSD) and depression over 2 years than those with stable right alpha asymmetry and lower levels of trauma. These findings suggest that developmental patterns of resting left frontal brain activity may buffer against psychopathology in maltreated female youth.
Using population viability analysis, genomics, and habitat suitability to forecast future population patterns of Little OwlAthene noctuaacross Europe
Authors: Andersen Line Holm , Sunde Peter , Pellegrino Irene , Loeschcke Volker , Pertoldi Cino 
Published: November 2017

AbstractThe agricultural scene has changed over the past decades, resulting in a declining population trend in many species. It is therefore important to determine the factors that the individual species depend on in order to understand their decline. The landscape changes have also resulted in habitat fragmentation, turning once continuous populations into metapopulations. It is thus increasingly important to estimate both the number of individuals it takes to create a genetically viable population and the population trend. Here, population viability analysis and habitat suitability modeling were used to estimate population viability and future prospects across Europe of the Little OwlAthene noctua, a widespread species associated with agricultural landscapes. The results show a high risk of population declines over the coming 100 years, especially toward the north of Europe, whereas populations toward the southeastern part of Europe have a greater probability of persistence. In order to be considered genetically viable, individual populations must count 1,000–30,000 individuals. As Little Owl populations of several countries count <30,000, and many isolated populations in northern Europe count <1,000 individuals, management actions resulting in exchange of individuals between populations or even countries are probably necessary to prevent losing <1% genetic diversity over a 100‐year period. At a continental scale, a habitat suitability analysis suggested Little Owl to be affected positively by increasing temperatures and urban areas, whereas an increased tree cover, an increasing annual rainfall, grassland, and sparsely vegetated areas affect the presence of the owl negatively. However, the low predictive power of the habitat suitability model suggests that habitat suitability might be better explained at a smaller scale.
In situ production of active vitamin B12 in cereal matrices using Propionibacterium freudenreichii
Authors: Chamlagain Bhawani , Sugito Tessa A. , Deptula Paulina , Edelmann Minnamari , Kariluoto Susanna , Varmanen Pekka , Piironen Vieno 
Published: November 2017

AbstractThe in situ production of active vitamin B12 was investigated in aqueous cereal‐based matrices with three strains of food‐grade Propionibacterium freudenreichii. Matrices prepared from malted barley flour (33% w/v; BM), barley flour (6%; BF), and wheat aleurone (15%; AM) were fermented. The effect of cobalt and the lower ligand 5,6‐dimethylbenzimidazole (DMBI) or its natural precursors (riboflavin and nicotinamide) on active B12 production was evaluated. Active B12 production was confirmed by UHPLC–UV–MS analysis. A B12 content of 12–37 μg·kg−1 was produced in BM; this content increased 10‐fold with cobalt and reached 940–1,480 μg·kg−1 with both cobalt and DMBI. With riboflavin and nicotinamide, B12 production in cobalt‐supplemented BM increased to 712 μg·kg−1. Approximately, 10 μg·kg−1 was achieved in BF and AM and was increased to 80 μg·kg−1 in BF and 260 μg·kg−1 in AM with cobalt and DMBI. The UHPLC and microbiological assay (MBA) results agreed when both cobalt and DMBI or riboflavin and nicotinamide were supplemented. However, MBA gave ca. 20%–40% higher results in BM and AM supplemented with cobalt, indicating the presence of human inactive analogues, such as pseudovitamin B12. This study demonstrates that cereal products can be naturally fortified with active B12 to a nutritionally relevant level by fermenting with P. freudenreichii.
Visual evaluation of sliced Italian salami by image analysis
Authors: Romano Annalisa , Masi Paolo , Cavella Silvana 
Published: November 2017

AbstractVisual inspection is an important part of quality control not only for manufacturers but also for retailers and consumers. The object of this investigation was to determine fat content in sliced salami by means of image analysis. The image analysis procedure is applied to digital images of sliced Italian salami produced in 16 different salami factories (A–P). The image analysis method described in this work is nondestructive and the necessary equipment is cheap. It extracts directly interpretable parameters of fat particle morphology (e.g., area, roundness) and number of fat particles from 15 digital images for each sample (A–P). The correlations between the fat features extracted from the images with the chemical fat content measured on the samples were also studied. Good relationships were found between the fat particle characteristics measured by image analysis procedure and the percentage of chemically extractable fat by correlation (R2=0.75) and principal component analysis.
Synthesis of thermo‐responsive bovine hemoglobin imprinted nanoparticles by combining ionic liquid immobilization with aqueous precipitation polymerization
Authors: Wang Yongmei , Yang Chongchong , Sun Yan , Qiu Fengtao , Xiang Yang , Fu Guoqi 
Published: November 2017

AbstractSurface molecular imprinting over functionalized nanoparticles has proved to be an effective approach for construction of artificial nanomaterials for protein recognition. Herein, we report a strategy for synthesis of core–shell protein‐imprinted nanoparticles by the functionalization of nano‐cores with ionic liquids followed by aqueous precipitation polymerization to build thermo‐responsive imprinted polymer nano‐shells. The immobilized ionic liquids can form multiple interactions with the protein template. The polymerization process can produce thermo‐reversible physical crosslinks, which are advantageous to enhancing imprinting and facilitating template removal. With bovine hemoglobin as a model template, the imprinted nanoparticles showed temperature‐sensitivity in both dispersion behaviors and rebinding capacities. Compared with the ionic‐liquid‐modified core nanoparticles, the imprinted particles exhibited greatly increased selectivity and two orders of magnitude higher binding affinity for the template protein. The imprinted nanoparticles achieved relatively high imprinting factor up to 5.0 and specific rebinding capacity of 67.7 mg/g, respectively. These nanoparticles also demonstrated rapid rebinding kinetics and good reproducibility after five cycles of adsorption–regeneration. Therefore, the presented approach may be viable for the fabrication of high‐performance protein‐imprinted nanoparticles with temperature sensitivity.