bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Shunting After Aneurysmal Subarachnoid Hemorrhage
Authors: Adams Hadie , Ban Vin Shen , Leinonen Ville , Aoun Salah G. , Huttunen Jukka , Saavalainen Taavi , Lindgren Antti , Frosen Juhana , Fraunberg Mikael , Koivisto Timo , Hernesniemi Juha , Welch Babu G. , Jaaskelainen Juha E. , Huttunen Terhi J. 
Published: September 2016

Background and Purpose—
Shunt dependent hydrocephalus after aneurysmal subarachnoid hemorrhage (aSAH) is a common sequela that may lead to poor neurological outcome and predisposes to various interventions, admissions, and complications. We reviewed post-aSAH shunt dependency in a population-based sample and tested the feasibility of a clinical risk score to identify subgroups of aSAH patients with increasing risk of shunting for hydrocephalus.

Methods—
A total of 1533 aSAH patients from the population-based Eastern Finland Saccular Intracranial Aneurysm Database (Kuopio, Finland) were used in a recursive partitioning analysis to identify risk factors for shunting after aSAH. The risk model was built and internally validated in random split cohorts. External validation was conducted on 946 aSAH patients from the Southwestern Tertiary Aneurysm Registry (Dallas, TX) and tested using receiver-operating characteristic curves.

Results—
Of all patients alive ≥14 days, 17.7% required permanent cerebrospinal fluid diversion. The recursive partitioning analysis defined 6 groups with successively increased risk for shunting. These groups also successively risk stratified functional outcome at 12 months, shunt complications, and time-to-shunt rates. The area under the curve–receiver-operating characteristic curve for the exploratory sample and internal validation sample was 0.82 and 0.78, respectively, with an external validation of 0.68.

Conclusions—
Shunt dependency after aSAH is associated with higher morbidity and mortality, and prediction modeling of shunt dependency is feasible with clinically useful yields. It is important to identify and understand the factors that increase risk for shunting and to eliminate or mitigate the reversible factors. The aSAH-PARAS Consortium (Aneurysmal Subarachnoid Hemorrhage Patients’ Risk Assessment for Shunting) has been initiated to pool the collective insights and resources to address key questions in post-aSAH shunt dependency to inform future aSAH treatment guidelines.
A second species, and first Central American record, of the phorid fly genus Lenkoa Borgmeier (Diptera: Phoridae)
Authors: BROWN BRIAN V. , PORRAS WENDY 
Published: September 2016

A second species, and first Central American record, of the phorid fly genus Lenkoa Borgmeier (Diptera: Phoridae). Many species of phorid flies have wingless or brachypterous females. Mostly, they belong to a group classified within the subfamily Metopininae corresponding to the Metopina group of genera of Brown (1992a) or the tribe Metopinini of Disney (2003, not 1987). The males of this group are much more typical in appearance, with well-developed wings, larger eyes, and fully developed abdominal tergites. These males carry females during a mating flight, often dispersing them to new breeding sites (Miller 1984). Generally, the sexual dimorphism is so great that the sexes cannot be confidently associated unless they are collected in copula. This has led to a profusion of species being described as males and females in separate genera. Some of these brachypterous females, both within the Metopinini and elsewhere in other Phoridae, have been correctly associated with their males when they are found together (e.g., Brown 1986, 1992b, 1994), but many remain unassociated.
Toward Understanding the Properties of High Ice Clouds at the Naqu Site on the Tibetan Plateau Using Ground-Based Active Remote Sensing Measurements Obtained during a Short Period in July 2014
Authors: Zhao Chuanfeng , Liu Liping , Wang Qianqian , Qiu Yanmei , Wang Wei , Wang Yang , Fan Tianyi 
Published: September 2016

AbstractThis study describes the microphysical properties of high ice clouds (with bases above 5 km) using ground-based millimeter cloud radar cirrus-mode observations over the Naqu site of the Tibetan Plateau (TP) during a short period from 6 to 31 July 2014. Empirical regression equations are applied for the cloud retrievals in which the parameters are given on the basis of a review of existing literature. The results show a unimodal distribution for the cloud ice effective radius re and ice water content with maximum frequencies around 36 μm and 0.001 g m−3, respectively. Analysis shows that clouds with high ice re are more likely to occur at times from late afternoon until nighttime. The clouds with large (small) re mainly occur at low (high) heights and are likely orographic cumulus or stratocumulus (thin cirrus). Further analysis indicates that ice re decreases with increasing height and shows strong positive relationships between ice re (μm) and depth h (m), with a regression equation of re = 35.45 + 0.0023h + (1.7 × 10−7)h2. A good relationship between ice re and temperature T (°C) is found, re = 44.65 + 0.1438T, which could serve as a baseline for retrieval of characteristic ice re properties over the TP.
Criminals in Our Midst: Middle-Class Reactions to Representations of the “Ordinary” in a Buenos Aires Shantytown
Authors: Lederman Jacob 
Published: September 2016

Building upon the concept of moral indignation, an analysis of the social reaction to a Buenos Aires shantytown shows how discourses that emphasize the criminality of its inhabitants are mobilized to explain the economic and ontological instability experienced by the local middle class. The media’s use of rhetorical frames that highlight the lack of boundaries between the middle-class readership and the residents of the shantytown produces indignation directed against the urban poor. The newspaper’s readership reconstructs social difference through discourses that frame the shantytown’s inhabitants as predatory, undeserving, and dangerous. Partiendo del concepto de indignación moral, el análisis de la reacción social a una villa miseria de Buenos Aires demuestra como los discursos que enfatizan la criminalidad de los habitantes de la barriada son usados para explicar la inestabilidad económica y ontológica que sufre la clase media local. Los medios usan marcos retóricos que resaltan la falta de fronteras entre sus lectores de clase media y los residentes de las barriadas pobres y esto produce una indignación dirigida contra los pobres de las zonas urbanas. Los lectores del periódico reconstruyen las diferencias sociales por medio de discursos que definen a los habitantes de esas barriadas como depredadores, indignos y peligrosos.
Identification of two phosphorylation sites essential for annexin A1 in blood–brain barrier protection after experimental intracerebral hemorrhage in rats
Authors: Wang Zhong , Chen Zhouqing , Yang Junjie , Yang Ziying , Yin Jia , Zuo Gang , Duan Xiaochun , Shen Haitao , Li Haiying , Chen Gang 
Published: September 2016

Annexin A1 has been reported to exert a blood–brain barrier protection. This study was designed to examine the role of annexin A1 in intracerebral hemorrhage-induced blood–brain barrier dysfunction. A collagenase intracerebral hemorrhage model was performed in adult male Sprague Dawley rats. First, a possible relationship between annexin A1 and intracerebral hemorrhage pathology was confirmed by a loss of annexin A1 in the cerebrovascular endothelium and serum of intracerebral hemorrhage rats, and the rescue effects of i.v. administration of human recombinant annexin A1 in vivo and annexin A1 overexpression in vitro on the barrier function of brain microvascular endothelial cells exposed to intracerebral hemorrhage stimulus. Second, we found that intracerebral hemorrhage significantly increased the phosphorylation ratio of annexin A1 at the serine/threonine residues. Finally, based on site-specific mutagenesis, we identified two phosphorylation sites (a) annexin A1 phosphorylation at threonine 24 is required for its interaction with actin cytoskeleton, and (b) phosphorylation at serine27 is essential for annexin A1 secretion, both of which were essential for maintaining cytoskeleton integrity and paracellular permeability. In conclusion, annexin A1 prevents intracerebral hemorrhage-induced blood–brain barrier dysfunction in threonine 24 and serine27 phosphorylation-dependent manners. Annexin A1 phosphorylation may be a self-help strategy in brain microvascular endothelial cells after intracerebral hemorrhage; however, that was almost completely abolished by the intracerebral hemorrhage-induced loss of annexin A1.
Review of Systemic Treatment Options for Adult Atopic Dermatitis
Authors: Gooderham Melinda , Lynde Charles W. , Papp Kim , Bourcier Marc , Guenther Lyn , Gulliver Wayne , Hong Chih-ho , Poulin Yves , Sussman Gordon , Vender Ronald 
Published: September 2016

Background: Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease resulting from defects in skin barrier and aberrant immune responses. AD significantly affects the quality of life. Not all patients respond to topical therapies, and often systemic therapy is required to control the disease. Objective: To review the treatment options for adult AD patients including those options for patients who do not respond adequately or have contraindications to oral systemic therapy. Methods: A working group of clinicians with experience managing AD was convened to review the current literature on treatment options for adult AD patients. This review is based on the best available evidence from a published systematic review and an additional literature search. Results: Current treatments for AD are reviewed, including options for adult AD patients who do not respond or have contraindications to current systemic therapies. A new approach with targeted therapies is reviewed based on best available evidence. Conclusion: Many AD patients respond satisfactorily to topical or systemic treatments, but for those patients who do not respond or have contraindications, new biologic agents appear to be promising therapies.
Interviews With Patients Who Traveled From Macedonia/Kosovo, The Netherlands, and Sweden for Paid Kidney Transplantations
Authors: van Balen L. J. , Ambagtsheer Frederike , Ivanovski N. , Weimar W. 
Published: September 2016

Background: Patients travel worldwide for paid kidney transplants. Although transplantations abroad are not always illegal, they are commonly perceived to be illegal and unethical involving risks. Aim: We aimed to describe the motivations and experiences of patients who traveled abroad for paid kidney transplantations and to examine how these transplantations were facilitated. Methods: We interviewed 22 patients who traveled from Macedonia/Kosovo, the Netherlands, and Sweden for paid kidney transplantations between years 2000 and 2009. Results: Patients traveled because of inadequate transplant activity in their domestic countries and dialysis-related complaints. However, 6 patients underwent preemptive transplantations. Cultural factors such as patients’ affinity with destination countries, feelings of being discriminated against by the health-care system, and family ties also help explain why patients travel abroad. Seven of the 22 patients went to their country of origin. They were able to organize their transplantations by arranging help from family and friends abroad who provided contacts of caregivers there and who helped cover the costs of their transplants. The costs varied from €5000 to €45 000 (US$6800-US$61 200). Seven patients paid the hospital, 5 paid their doctor, 4 paid a broker, and 6 paid their donors. Conclusion: Research should include interviews with brokers, transplant professionals, and other facilitators to achieve a full picture of illegally performed transplantations.
Understanding Differences in Helicopter Mission Sets Prior to Human Error Analysis
Authors: Morowsky Katarina , Funk Kenneth H. 
Published: September 2016

Helicopters are essential for completion of many critical missions that are impossible for fixed-wing aircraft since they can operate around rough terrain and require minimal ground infrastructure. Like many complex environments, human error is thought to be a contributing factor for roughly eighty percent of helicopter accidents. While the aviation industry favors umbrella strategies within the United States Federal Aviation Regulations, this approach may be less than optimal for rotor-wing operations given the diversity of tasks within different mission sets. To understand the differences in tasks across mission sets, interviews were conducted with pilots to create Hierarchical Task Analysis (HTA) models of tasks required to successfully complete Helicopter Air Ambulance (HAA) and Maritime Search and Rescue (SAR) missions. The HTA models were compared to identify differences in tasks across missions. The tasks identified within the HTA models will be combined with findings from subsequent accident report analysis studies to develop mitigation strategies specific to helicopter missions.
Sortilin regulates sorting and secretion of Sonic hedgehog
Authors: Campbell Charles , Beug Shawn , Nickerson Philip E. B. , Peng Jimmy , Mazerolle Chantal , Bassett Erin A. , Ringuette Randy , Jama Fadumo A. , Morales Carlos , Christ Annabel , Wallace Valerie A. 
Published: September 2016

ABSTRACT
Sonic Hedgehog (Shh) is a secreted morphogen that is an essential regulator of patterning and growth. The Shh full-length protein undergoes autocleavage in the endoplasmic reticulum to generate the biologically active N-terminal fragment (ShhN), which is destined for secretion. We identified sortilin (Sort1), a member of the VPS10P-domain receptor family, as a new Shh trafficking receptor. We demonstrate that Sort–Shh interact by performing coimmunoprecipitation and proximity ligation assays in transfected cells and that they colocalize at the Golgi. Sort1 overexpression causes re-distribution of ShhN and, to a lesser extent, of full-length Shh to the Golgi and reduces Shh secretion. We show loss of Sort1 can partially rescue Hedgehog-associated patterning defects in a mouse model that is deficient in Shh processing, and we show that Sort1 levels negatively regulate anterograde Shh transport in axons in vitro and Hedgehog-dependent axon–glial interactions in vivo. Taken together, we conclude that Shh and Sort1 can interact at the level of the Golgi and that Sort1 directs Shh away from the pathways that promote its secretion.
Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy
Authors: Tobin Stephanie Wales , Yang Dabo , Girgis John , Farahzad Ali , Blais Alexandre , McDermott John C. 
Published: September 2016

ABSTRACT
Mycocyte enhancer factor 2 (MEF2) and activator protein 1 (AP-1) transcription complexes have been individually implicated in myogenesis, but their genetic interaction has not previously been addressed. Using MEF2A, c-Jun and Fra-1 chromatin immunoprecipitation sequencing (ChIP-seq) data and predicted AP-1 consensus motifs, we identified putative common MEF2 and AP-1 target genes, several of which are implicated in regulating the actin cytoskeleton. Because muscle atrophy results in remodelling or degradation of the actin cytoskeleton, we characterized the expression of putative MEF2 and AP-1 target genes (Dstn, Flnc, Hspb7, Lmod3 and Plekhh2) under atrophic conditions using dexamethasone (Dex) treatment in skeletal myoblasts. Heat shock protein b7 (Hspb7) was induced by Dex treatment and further analyses revealed that loss of MEF2A using siRNA prevented Dex-regulated induction of Hspb7. Conversely, ectopic Fra-2 or c-Jun expression reduced Dex-mediated upregulation of Hspb7 whereas AP-1 depletion enhanced Hspb7 expression. In vivo, expression of Hspb7 and other autophagy-related genes was upregulated in response to atrophic conditions in mice. Manipulation of Hspb7 levels in mice also impacted gross muscle mass. Collectively, these data indicate that MEF2 and AP-1 confer antagonistic regulation of Hspb7 gene expression in skeletal muscle, with implications for autophagy and muscle atrophy.
Field-oriented control of five-phase induction motor with open-end stator winding
Authors: Listwan Jacek , Pieńkowski Krzysztof 
Published: September 2016

Abstract
The mathematical model of the five-phase squirrel-cage induction motor and the system of the dual five-phase voltage source inverter have been presented. The control methods and control systems of the field-oriented control of the five-phase induction motor with an open-end stator winding are described. The structures of the direct fieldoriented control system (DFOC) and the Indirect Field-oriented control system (IFOC) with PI controllers in outer and inner control loops are analyzed. A method of space vector modulation used to control the system of the dual five-phase voltage source inverter has been discussed. The results of simulation studies of the field-oriented control methods are presented. Comparative analysis of the simulation results was carried out.
The flying-capacitor SEPIC converter with the balancing circuit
Authors: Kawa Adam , Stala Robert 
Published: September 2016

AbstractThe paper presents investigation results of the natural balancing phenomena in the flying-capacitor SEPIC converters. The SEPIC converters topologies can be reconfigured to the flying-capacitor topology. Owing to this modification the advantageous increase of frequency of the current in the chokes and the decrease of semiconductors voltages can be achieved which is shown in this paper. Similarly to other multilevel flying capacitor topologies the adequate voltage sharing of the flying capacitors is an important issue for safe operation of the converter. The paper focuses on the analysis of the flying capacitor voltages balancing in the converter by natural currents as well as by the application of the additional RLC balancing booster. The paper proves that the natural balancing can be achieved by the specific application of the balancing circuit in the flying-capacitor SEPIC topology and proves the specific differences in the balancing process by natural currents of converter and with the usage of the balancing circuit. An operation of the converter with the balancing circuit and the natural balancing ability is studied here.
A new technique to design planar dipole antennas by using Bezier curve and Particle Swarm Optimization
Authors: Homsup Nuttaka , Silabut Winyou , Kesornpatumanum Vuttichai , Boonek Pravit , Kuhirun Waroth 
Published: September 2016

Abstract
This research presents a new technique which includes the principle of a Bezier curve and Particle Swarm Optimization (PSO) together, in order to design the planar dipole antenna for the two different targets. This technique can improve the characteristics of the antennas by modifying copper textures on the antennas with a Bezier curve. However, the time to process an algorithm will be increased due to the expansion of the solution space in optimization process. So as to solve this problem, the suitable initial parameters need to be set. Therefore this research initialized parameters with reference antenna parameters (a reference antenna operates on 2.4 GHz for IEEE 802.11 b/g/n WLAN standards) which resulted in the proposed designs, rapidly converted into the goals. The goal of the first design is to reduce the size of the antenna. As a result, the first antenna is reduced in the substrate size from areas of 5850 mm2 to 2987 mm2 (48.93% approximately) and can also operates at 2.4 GHz (2.37 GHz to 2.51 GHz). The antenna with dual band application is presented in the second design. The second antenna is operated at 2.4 GHz (2.40 GHz to 2.49 GHz) and 5 GHz (5.10 GHz to 5.45 GHz) for IEEE 802.11 a/b/g/n WLAN standards.
Modelling of a non-linear coil with loss in iron using the Runge-Kutta methods
Authors: Kolańska-Płuska Joanna , Grochowicz Barbara 
Published: September 2016

Abstract
This work presents a study on dynamics of a circuit with a non-linear coil, where loss in iron is also taken into account. A coil model is derived using a state space description. The work also includes the development of an application in C# for coil dynamics examination, where the implicit RADAU IIA method of various orders is applied for the purpose of solving non-linear differential equations modelling the non-linear coil with loss in iron.
Multi-objective analysis of Polish domestic power system development from point of view of unmanned factories. A cybernetic issue
Authors: Tchórzewski Jerzy 
Published: September 2016

Abstract
The paper contains selected results of research on the Domestic Power System (DPS) as an unmanned factory. Models of the DPS system of the MISO type, obtained as a result of identification for 14 inputs and 4 outputs were presented. Particular attention was given to the identification and the assessment of the DPS development based on the systems and control theory. The obtained models of the DPS development were analyzed and discussed. The studies were obtained model of the development of the DPS, and on the basis of is knowledge of the structural and parametrical changes of system development. The model can be used to analyze the design and development of the system from the point of view of the growth of internal organization system and the transition to higher levels of control.
Wrong transition and measurement models in power system state estimation
Authors: Kozierski Piotr , Lis Marcin , Horla Dariusz 
Published: September 2016

Abstract
The influence of wrong information about transition and measurement models on estimation quality has been presented in the paper. Two methods of a particle filter, with and without the Population Monte Carlo modification, and also the extended and unscented Kalman filters methods have been compared. A small 5-bus power system has been used in simulations, which have been performed based on one data set, and this data set has been chosen from among 100 different - to draw the most general conclusions. Based on the obtained results it has been found that for the particle filter methods the implementation of the slightly higher standard deviation than the true value, usually increases the estimation quality. For the Kalman filters methods it has been concluded that optimal values of variances are equal to the true values.
Algorithm for determining two-periodic steady-states in AC machines directly in time domain
Authors: Sobczyk Tadeusz J. 
Published: September 2016

Abstract
This paper describes an algorithm for finding steady states in AC machines for the cases of their two-periodic nature. The algorithm enables to specify the steady-state solution identified directly in time domain despite of the fact that two-periodic waveforms are not repeated in any finite time interval. The basis for such an algorithm is a discrete differential operator that specifies the temporary values of the derivative of the two-periodic function in the selected set of points on the basis of the values of that function in the same set of points. It allows to develop algebraic equations defining the steady state solution reached in a chosen point set for the nonlinear differential equations describing the AC machines when electrical and mechanical equations should be solved together. That set of those values allows determining the steady state solution at any time instant up to infinity. The algorithm described in this paper is competitive with respect to the one known in literature an approach based on the harmonic balance method operated in frequency domain.