bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomenclature for congenital and paediatric cardiac disease: the International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Iteration of the International Classification of Diseases (ICD-11)
Authors: Franklin Rodney C. G. , Béland Marie J. , Colan Steven D. , Walters Henry L. , Aiello Vera D. , Anderson Robert H. , Bailliard Frédérique , Boris Jeffrey R. , Cohen Meryl S. , Gaynor J. William , Guleserian Kristine J. , Houyel Lucile , Jacobs Marshall L. , Juraszek Amy L. , Krogmann Otto N. , Kurosawa Hiromi , Lopez Leo , Maruszewski Bohdan J. , St. Louis James D. , Seslar Stephen P. , Srivastava Shubhika , Stellin Giovanni , Tchervenkov Christo I. , Weinberg Paul M. , Jacobs Jeffrey P. 
Published: December 2017

AbstractAn internationally approved and globally used classification scheme for the diagnosis of CHD has long been sought. The International Paediatric and Congenital Cardiac Code (IPCCC), which was produced and has been maintained by the International Society for Nomenclature of Paediatric and Congenital Heart Disease (the International Nomenclature Society), is used widely, but has spawned many “short list” versions that differ in content depending on the user. Thus, efforts to have a uniform identification of patients with CHD using a single up-to-date and coordinated nomenclature system continue to be thwarted, even if a common nomenclature has been used as a basis for composing various “short lists”. In an attempt to solve this problem, the International Nomenclature Society has linked its efforts with those of the World Health Organization to obtain a globally accepted nomenclature tree for CHD within the 11th iteration of the International Classification of Diseases (ICD-11). The International Nomenclature Society has submitted a hierarchical nomenclature tree for CHD to the World Health Organization that is expected to serve increasingly as the “short list” for all communities interested in coding for congenital cardiology. This article reviews the history of the International Classification of Diseases and of the IPCCC, and outlines the process used in developing the ICD-11 congenital cardiac disease diagnostic list and the definitions for each term on the list. An overview of the content of the congenital heart anomaly section of the Foundation Component of ICD-11, published herein in its entirety, is also included. Future plans for the International Nomenclature Society include linking again with the World Health Organization to tackle procedural nomenclature as it relates to cardiac malformations. By doing so, the Society will continue its role in standardising nomenclature for CHD across the globe, thereby promoting research and better outcomes for fetuses, children, and adults with congenital heart anomalies.
The 2017 Seventh World Congress of Paediatric Cardiology and Cardiac Surgery: “The Olympics of our Profession”
Authors: Cohen Mitchell I. , Jacobs Jeffrey P. , Cicek Sertac 
Published: December 2017

AbstractThe 1st World Congress of Paediatric Cardiology was held in London, United Kingdom, in 1980, organised by Dr Jane Somerville and Prof. Fergus Macartney. The idea was that of Jane Somerville, who worked with enormous energy and enthusiasm to bring together paediatric cardiologists and surgeons from around the world. The 2nd World Congress of Paediatric Cardiology took place in New York in 1985, organised by Bill Rashkind, Mary Ellen Engle, and Eugene Doyle. The 3rd World Congress of Paediatric Cardiology was held in Bangkok, Thailand, in 1989, organised by Chompol Vongraprateep. Although cardiac surgeons were heavily involved in these early meetings, a separate World Congress of Paediatric Cardiac Surgery was held in Bergamo, Italy, in 1988, organised by Lucio Parenzan. Thereafter, it was recognised that surgeons and cardiologists working on the same problems and driven by a desire to help children would really rather meet together. A momentous decision was taken to initiate a Joint World Congress of Paediatric Cardiology and Cardiac Surgery. A steering committee was established with membership comprising the main organisers of the four separate previous Congresses and additional members were recruited in an effort to achieve numerical equality of cardiologists and surgeons and a broad geographical representation. The historic 1st “World Congress of Paediatric Cardiology and Cardiac Surgery” took place in Paris in June, 1993, organised by Jean Kachaner. The next was to be held in Japan, but the catastrophic Kobe earthquake in 1995 forced relocation to Hawaii in 1997. Then followed Toronto, Canada, 2001, organised by Bill Williams and Lee Benson; Buenos Aires, Argentina, 2005, organised by Horatio Capelli and Guillermo Kreutzer; Cairns, Australia, 2009, organised by Jim Wilkinson; Cape Town, South Africa, 2013, organised by Christopher Hugo-Hamman; and Barcelona, Spain, 2017, organised by Sertac Cicek. With stops in Europe (1993), Asia-Pacific (1997), North America (2001), South America (2005), Australia (2009), Africa (2013), and Europe again (2017), in 2021, The World Congress of Paediatric Cardiology and Cardiac Surgery will be held for the first time in the continental United States.1 The 8th World Congress of Paediatric Cardiology and Cardiac Surgery will be held in Washington DC, United States of America, 19–24 September, 2021, and will be organised by Jeffrey P. Jacobs and Gil Wernovsky. Mitchell I. Cohen served as the Scientific Program Co-Chair for the 2017 World Congress of Paediatric Cardiology and Cardiac Surgery, and he will again serve as the Scientific Program Co-Chair for the 2021 World Congress of Paediatric Cardiology and Cardiac Surgery along with Kathyrn Dodds RN, MSN, CRNP. Information about the upcoming 8th World Congress of Paediatric Cardiology and Cardiac Surgery can be found at www.WCPCCS2021.org
Validation of a photographic seafood portion guide to assess fish and shrimp intakes
Authors: Mathews Anne E , Al-Rajhi Ali , Kane Andrew S 
Published: December 2017

AbstractObjectiveTo validate a novel photographic portion guide as a tool to estimate consumption of fish and shrimp. Application of such a validated tool can facilitate accurate individual and community seafood intake assessments and provide meaningful data relative to health benefits and hazard assessment, particularly in response to environmental contamination and disasters.DesignA photographic fish and shrimp portion guide presenting a stepped range of cooked portion sizes was used by participants to estimate their typical portion sizes. Participants selected their typical portion size from the photographic guide and also from a selection of freshly cooked reference meals. Photographic portions selections were compared with plated reference portions for each participant.SettingAcademic sensory testing laboratory in the USA.SubjectsSeparate groups of adults (25–64 years) contributed to fish (n54) and shrimp (n53) portion size comparison studies.ResultsIn the fish study, there was no difference between photographic portion selections (6·59 (sd2·65) oz (186·8 (sd75·1) g)) and reference plate selections (7·04 (sd2·63) oz (199·6 (sd74·6) g);P=0·384). Similarly in the shrimp study, there was no difference between photographic portion selections (6·88 (sd3·40) oz (195·0 (sd96·4) g)) and reference plate selections (6·06 (sd2·65) oz (171·8 (sd75·1) g);P=0·159). Photographic portions predicted plated reference portions for both fish and shrimp based on linear regression (P<0·001). Bland–Altman plot analyses showed good agreement between the two methods, <1 oz (<28·3 g) bias, in both fish and shrimp studies.ConclusionsThis validated photographic seafood portion guide provides a utilitarian tool for accurately assessing fish and shrimp intake in a community setting.
Acetylacetone photodynamics at a seeded free-electron laser
Authors: Squibb R. J. , Sapunar M. , Ponzi A. , Richter R. , Kivimäki A. , Plekan O. , Finetti P. , Sisourat N. , Zhaunerchyk V. , Marchenko T. , Journel L. , Guillemin R. , Cucini R. , Coreno M. , Grazioli C. , Di Fraia M. , Callegari C. , Prince K. C. , Decleva P. , Simon M. , Eland J. H. D. , Došlić N. , Feifel R. , Piancastelli M. N. 
Published: December 2017

AbstractThe first steps in photochemical processes, such as photosynthesis or animal vision, involve changes in electronic and geometric structure on extremely short time scales. Time-resolved photoelectron spectroscopy is a natural way to measure such changes, but has been hindered hitherto by limitations of available pulsed light sources in the vacuum-ultraviolet and soft X-ray spectral region, which have insufficient resolution in time and energy simultaneously. The unique combination of intensity, energy resolution, and femtosecond pulse duration of the FERMI-seeded free-electron laser can now provide exceptionally detailed information on photoexcitation–deexcitation and fragmentation in pump-probe experiments on the 50-femtosecond time scale. For the prototypical system acetylacetone we report here electron spectra measured as a function of time delay with enough spectral and time resolution to follow several photoexcited species through well-characterized individual steps, interpreted using state-of-the-art static and dynamics calculations. These results open the way for investigations of photochemical processes in unprecedented detail.
C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
Authors: Cheng Weiwei , Wang Shaopeng , Mestre Alexander A. , Fu Chenglai , Makarem Andres , Xian Fengfan , Hayes Lindsey R. , Lopez-Gonzalez Rodrigo , Drenner Kevin , Jiang Jie , Cleveland Don W. , Sun Shuying 
Published: December 2017

AbstractHexanucleotide repeat expansion inC9ORF72is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC)n-containing RNAs into poly-dipeptides can initiate in vivo without a 5′-cap. The primary RNA substrate for RAN translation of C9ORF72 sense repeats is shown to be the spliced first intron, following its excision from the initial pre-mRNA and transport to the cytoplasm. Cap-independent RAN translation is shown to be upregulated by various stress stimuli through phosphorylation of the α subunit of eukaryotic initiation factor-2 (eIF2α), the core event of an integrated stress response (ISR). Compounds inhibiting phospho-eIF2α-signaling pathways are shown to suppress RAN translation. Since the poly-dipeptides can themselves induce stress, these findings support a feedforward loop with initial repeat-mediated toxicity enhancing RAN translation and subsequent production of additional poly-dipeptides through ISR, thereby promoting progressive disease.
Iron diapirs entrain silicates to the core and initiate thermochemical plumes
Authors: Fleck J. R. , Rains C. L. , Weeraratne D. S. , Nguyen C. T. , Brand D. M. , Klein S. M. , McGehee J. M. , Rincon J. M. , Martinez C. , Olson P. L. 
Published: December 2017

AbstractSegregation of the iron core from rocky silicates is a massive evolutionary event in planetary accretion, yet the process of metal segregation remains obscure, due to obstacles in simulating the extreme physical properties of liquid iron and silicates at finite length scales. We present new experimental results studying gravitational instability of an emulsified liquid gallium layer, initially at rest at the interface between two glucose solutions. Metal settling coats liquid metal drops with a film of low density material. The emulsified metal pond descends as a coherent Rayleigh−Taylor instability with a trailing fluid-filled conduit. Scaling to planetary interiors and high pressure mineral experiments indicates that molten silicates and volatiles are entrained toward the iron core and initiate buoyant thermochemical plumes that later oxidize and hydrate the upper mantle. Surface volcanism from thermochemical plumes releases oxygen and volatiles linking atmospheric growth to the Earth’s mantle and core processes.
Brain Abscesses: An Overview in Children
Authors: Zangari Paola , De Luca Maia , Villani Alberto , Krzysztofiak Andrzej 
Published: December 2017

AbstractBrain abscesses in infants and children might be life threatening if not managed properly. They occur more frequently in the first two decades of life despite the reduced incidence of sinus and ear infections in pediatrics. The features of brain abscess in terms of location, pathogens, and symptoms depend on age and thus on predisposing factors. In infants and toddlers, bacterial meningitis or bacteremia is the major cause, and in older children, immunosuppression and cyanotic congenital heart diseases are common predisposing factors. The therapeutic management of brain abscesses involves a multidisciplinary team, including infectious disease specialist, neurosurgery, neuroradiology, and neurology. A prompt and long-term antimicrobial therapy is the mainstay of treatment, often associated with surgical drainage. These changes in the management have significantly improved the prognosis of patients with brain abscesses over the past 50 years.
Die ärztliche Kommunikation als Auslöser von Schlichtungsverfahren
Authors: Binter Isabell , Herold Christian , Allert Sixtus 
Published: December 2017

Zusammenfassung
Einleitung Die Grundlage einer vertrauensvollen Arzt-Patient-Beziehung wird unter anderem durch eine funktionierende Kommunikation
gebildet. Gute ärztliche Kommunikation ist in Zeiten von zunehmender Personal- und Zeitknappheit wichtiger denn je. Ziel dieser Arbeit war
zu prüfen, inwieweit ärztliche Kommunikation Einfluss auf die Auslösung von Schlichtungsverfahren hat.
Material und Methoden Analysiert wurden alle plastisch-chirurgischen Schlichtungsfälle, die die Norddeutschen Schlichtungsfälle für
Arzthaftpflichtfragen zwischen 2005 und 2015 abschließend bearbeitet hat. Nach Ausschluss der Fälle mit unvollständiger Datenlage wurden 280
Fälle ausgewertet. Die vorliegenden Unterlagen wurden auf Kommunikationsfehler und andere mögliche Auslöser des Verfahrens geprüft. Lagen
Kommunikationsfehler vor, wurden diese näher ausgewertet. Ferner wurde geprüft ob z. B. nachbehandelnde Ärzte Patienten Behandlungsfehler
suggerierten.
Ergebnisse 53,6 % aller Fälle ergaben Kommunikationsfehler in der Primärbehandlung. Kritischer Zeitraum ist die ambulante
Nachbehandlung (48,7 %), Hauptverursacher ist der behandelnde Arzt (93,7 %). In 30,9 % dieser Fälle fühlten sich die Patienten nicht ernst
genommen. Weitere Aspekte sind Nichtverfügbarkeit des behandelnden Arztes (12,2 %), Beleidigungen oder respektloser Umgang (8,5 %),
inadäquate Informationsbereitstellung (8,5 %) und fehlende Sicherungsaufklärung (8,1 %). In 43,9 % der Fälle wurde Patienten ein
Behandlungsfehler suggeriert. Vorrangiger Verursacher ist hier der nachbehandelnde Arzt (70,3 %).
Diskussion Es zeigt sich, dass eine fehlerhafte ärztliche Kommunikation erheblichen Einfluss auf die Gesamtzufriedenheit der Patienten
hat. Aussagen, die dem behandelnden Arzt ggf. normal erscheinen, können bei Patienten erhebliche emotionale Reaktionen hervorrufen. Die
vorliegende Arbeit zeigt, dass nicht nur „echte“ Behandlungsfehler und Schäden, sondern auch Kommunikationsprobleme Schlichtungsverfahren
auslösen. Gute Kommunikation und einfühlsamer Umgang helfen Unzufriedenheit zu mindern und senken das Risiko für mögliche juristische
Auseinandersetzungen.
Laudatio zur Salomon Neumann-Medaille 2017 an Herrn Prof. Dr. med. Bernt-Peter Robra, MPH
Authors: Raspe Heiner 
Published: December 2017

ZusammenfassungDie Deutsche Gesellschaft für Sozialmedizin und Prävention (DGSMP) verleiht die Salomon-Neumann-Medaille für besondere Verdienste um die Präventiv- und Sozialmedizin. Die Salomon Neumann-Medaille 2017 wurde an Bernt-Peter Robra, Institut für Sozialmedizin und Gesundheitsökonomie (ISMG) der Otto von Guericke Universität Magdeburg verliehen. Sie ehrt einen Sozialmediziner, in dessen Person und Institut die essentiellen Problemkreise der Sozialmedizin ebenso wie die Kompetenzen der 3 in Lübeck versammelten Fachgesellschaften - Epidemiologie, Medizinsoziologie und Sozialmedizin - und das sozialpolitische Engagement Salomon Neumanns zusammenkommen.
When linearity prevails over hierarchy in syntax
Authors: Willer Gold Jana , Arsenijević Boban , Batinić Mia , Becker Michael , Čordalija Nermina , Kresić Marijana , Leko Nedžad , Marušič Franc Lanko , Milićev Tanja , Milićević Nataša , Mitić Ivana , Peti-Stantić Anita , Stanković Branimir , Šuligoj Tina , Tušek Jelena , Nevins Andrew 
Published: December 2017

SignificanceSyntactic distance is standardly measured hierarchically only by counting the nodes in a tree-like structure. The dominance of hierarchy over the other logically possible measure of distance—e.g., counting words in a linear order—stems from a large body of research. We show a strong preference for the linear strategy in coordination structures in South Slavic languages, with a design comparing agreement controllers that can come either before or after their target. A large-scale study over six geographically and linguistically distinct varieties discovered remarkable uniformity in this preference. Variation discovered was mostly intraindividual, strongly suggesting that a language can entertain synchronous “multiple grammars,” the most striking of which is the one requiring direct reference to linear order.
PGA: post-GWAS analysis for disease gene identification
Authors: Lin Jhih-Rong , Jaroslawicz Daniel , Cai Ying , Zhang Quanwei , Wang Zhen , Zhang Zhengdong D 
Published: December 2017

Abstract

Summary
Although the genome-wide association study (GWAS) is a powerful method to identify disease-associated variants, it does not directly address the biological mechanisms underlying such genetic association signals. Here, we present PGA, a Perl- and Java-based program for post-GWAS analysis that predicts likely disease genes given a list of GWAS-reported variants. Designed with a command line interface, PGA incorporates genomic and eQTL data in identifying disease gene candidates and uses gene network and ontology data to score them based upon the strength of their relationship to the disease in question.

Availability and implementation
http://zdzlab.einstein.yu.edu/1/pga.html

Supplementary information
Supplementary data are available at Bioinformatics online.
An Interpretable Machine Learning Model for Accurate Prediction of Sepsis in the ICU
Authors: Nemati Shamim , Holder Andre , Razmi Fereshteh , Stanley Matthew D. , Clifford Gari D. , Buchman Timothy G. 
Published: December 2017

Objectives:
Sepsis is among the leading causes of morbidity, mortality, and cost overruns in critically ill patients. Early intervention with antibiotics improves survival in septic patients. However, no clinically validated system exists for real-time prediction of sepsis onset. We aimed to develop and validate an Artificial Intelligence Sepsis Expert algorithm for early prediction of sepsis.

Design:
Observational cohort study.

Setting:
Academic medical center from January 2013 to December 2015.

Patients:
Over 31,000 admissions to the ICUs at two Emory University hospitals (development cohort), in addition to over 52,000 ICU patients from the publicly available Medical Information Mart for Intensive Care-III ICU database (validation cohort). Patients who met the Third International Consensus Definitions for Sepsis (Sepsis-3) prior to or within 4 hours of their ICU admission were excluded, resulting in roughly 27,000 and 42,000 patients within our development and validation cohorts, respectively.

Interventions:
None.

Measurements and Main Results:
High-resolution vital signs time series and electronic medical record data were extracted. A set of 65 features (variables) were calculated on hourly basis and passed to the Artificial Intelligence Sepsis Expert algorithm to predict onset of sepsis in the proceeding T hours (where T = 12, 8, 6, or 4). Artificial Intelligence Sepsis Expert was used to predict onset of sepsis in the proceeding T hours and to produce a list of the most significant contributing factors. For the 12-, 8-, 6-, and 4-hour ahead prediction of sepsis, Artificial Intelligence Sepsis Expert achieved area under the receiver operating characteristic in the range of 0.83–0.85. Performance of the Artificial Intelligence Sepsis Expert on the development and validation cohorts was indistinguishable.

Conclusions:
Using data available in the ICU in real-time, Artificial Intelligence Sepsis Expert can accurately predict the onset of sepsis in an ICU patient 4–12 hours prior to clinical recognition. A prospective study is necessary to determine the clinical utility of the proposed sepsis prediction model.
Fractional microablative CO2 laser in breast cancer survivors affected by iatrogenic vulvovaginal atrophy after failure of nonestrogenic local treatments: a retrospective study
Authors: Pagano Tiziana , De Rosa Pasquale , Vallone Roberta , Schettini Francesco , Arpino Grazia , Giuliano Mario , Lauria Rossella , De Santo Irene , Conforti Alessandro , Gallo Alessandra , Nazzaro Giovanni , De Placido Sabino , Locci Mariavittoria , De Placido Giuseppe 
Published: December 2017

Abstract

Objective:
Vulvovaginal atrophy (VVA) is a condition frequently observed in menopause. Its symptoms can significantly affect the quality of life of patients. Since VVA is related to estrogen deficiency, chemotherapy and hormone therapy for breast cancer (BC) might cause VVA by inducing menopause. Given the lack of effective treatment for VVA in BC survivors, we retrospectively evaluated the efficacy and tolerability of fractional microablative CO2 laser therapy in these patients.

Methods:
We treated 82 BC survivors with three cycles of CO2 laser after failure of topical nonestrogenic therapy. The severity of symptoms was assessed with a visual analog scale (VAS) at baseline and after completion of laser therapy. Differences in mean VAS scores of each symptom before and after treatment were assessed with multiple t tests for pairwise comparisons. Multivariate analyses were used to adjust the final mean scores for the main confounding factors.

Results:
Pre versus post-treatment differences in mean VAS scores were significant for sensitivity during sexual intercourse, vaginal dryness, itching/stinging, dyspareunia and dysuria (P < 0.001 for all), bleeding (P = 0.001), probe insertion (P = 0.001), and movement-related pain (P = 0.011). Multivariate analyses confirmed that results were significant, irrespective of patients’ age and type of adjuvant therapy.

Conclusion:
This study shows that CO2 laser treatment is effective and safe in BC patients with iatrogenic menopause. However, the optimal number of cycles to administer and the need for retreatment remain to be defined. Prospective trials are needed to compare CO2 laser therapy with therapeutic alternatives.