bluuebunny/crossref_metadata_2025_split huggingface dataset:
Purpose, processes, partnerships, and products: four Ps to advance participatory socio‐environmental modeling
Authors: Gray Steven , Voinov Alexey , Paolisso Michael , Jordan Rebecca , BenDor Todd , Bommel Pierre , Glynn Pierre , Hedelin Beatrice , Hubacek Klaus , Introne Josh , Kolagani Nagesh , Laursen Bethany , Prell Christina , Schmitt Olabisi Laura , Singer Alison , Sterling Eleanor , Zellner Moira 
Published: September 2017

AbstractIncluding stakeholders in environmental model building and analysis is an increasingly popular approach to understanding ecological change. This is because stakeholders often hold valuable knowledge about socio‐environmental dynamics and collaborative forms of modeling produce important boundary objects used to collectively reason about environmental problems. Although the number of participatory modeling (PM) case studies and the number of researchers adopting these approaches has grown in recent years, the lack of standardized reporting and limited reproducibility have prevented PM's establishment and advancement as a cohesive field of study. We suggest a four‐dimensional framework (4P) that includes reporting on dimensions of (1) the Purpose for selecting a PM approach (the why); (2) the Process by which the public was involved in model building or evaluation (the how); (3) the Partnerships formed (the who); and (4) the Products that resulted from these efforts (the what). We highlight four case studies that use common PM software‐based approaches (fuzzy cognitive mapping, agent‐based modeling, system dynamics, and participatory geospatial modeling) to understand human–environment interactions and the consequences of ecological changes, including bushmeat hunting in Tanzania and Cameroon, agricultural production and deforestation in Zambia, and groundwater management in India. We demonstrate how standardizing communication about PM case studies can lead to innovation and new insights about model‐based reasoning in support of ecological policy development. We suggest that our 4P framework and reporting approach provides a way for new hypotheses to be identified and tested in the growing field of PM.
MnO2 Nanoflowers and Reduced Graphene Oxide 3D Composites for Ultrahigh‐Energy‐Density Asymmetric Supercapacitors
Authors: Zhang Junying , Zhang Xiaoming , Liu Zhi , Zheng Jun , Zuo Yuhua , Xue Chunlai , Li Chuanbo , Cheng Buwen , Wang Qiming 
Published: September 2017

AbstractUniform MnO2 nanoflowers and a reduced graphene oxide (rGO) 3D nanostructure composite are synthesized on Ni foam using a two‐step electrodeposition and hydrothermal method. The surface morphology and composition of the 3D nanostructure hybrid are intensively analyzed. MnO2/rGO/Ni is tested using a typical three‐electrode system for potential use as a supercapacitor electrode. The hybrid electrode has a high areal specific capacitance. An asymmetric supercapacitor (ASC) device is assembled and characterized using MnO2/rGO/Ni as the positive electrode and rGO/Ni as the negative electrode to further evaluate the electrochemical capability of the hybrids. Electrochemical characterizations indicate that the ASC device can be cycled reversibly between 0 V and 2.0 V in 1 m Na2SO4 aqueous electrolyte. The maximum areal specific capacitance of 760.1 mF cm−2 (1266.83 F g−1) and the maximum ultrahigh energy density of 150.45 Wh kg−1 are obtained, demonstrating the potential for use as binder‐free electrodes in pseudocapacitors.
Use of a clinical‐laboratory score to guide treatment of gestational diabetes
Authors: do Valle Juliana B. , Silva Jean C. , Oliveira Daniela S. , Martins Lisiane , Lewandowski Amanda , Horst Wagner 
Published: September 2017

AbstractObjectiveTo assess the outcomes of implementing a clinical‐laboratory score in the treatment of pregnant women with gestational diabetes.MethodsA retrospective before‐and‐after implementation analysis was undertaken using data and neonatal outcomes for pregnant women with gestational diabetes treated before (January 2011–December 2012; control group) and after (January 2013–December 2014; score group) introduction of a newly developed score. To evaluate the effects of score adoption, odds ratios with 95% confidence intervals were calculated after adjustment for confounding factors.ResultsThe control group included a greater proportion of women treated with diet alone (170/312 [54.5%]) than the study group did (122/391 [31.2%]; P<0.001). By contrast, more women in the study group received metformin (172 [44.0%] vs 77 [24.7%]; P<0.001). The neonatal outcomes, including low Apgar scores at 1 minute and at 5 minutes and neonatal intensive care unit admission, were similar in both groups. Multivariate logistic regression analysis showed that the adoption of the score did not significantly affect the choice of treatment or the birth weight rating.ConclusionThe score served well as an orientation tool in therapeutic decision making and had no negative effect on the treatment choice and perinatal outcomes.
Stem cell mobilization in patients with dialysis‐dependent multiple myeloma: Report of the Polish Myeloma Study Group
Authors: Waszczuk‐Gajda Anna , Drozd‐Sokołowska Joanna , Boguradzki Piotr , Dybko Jarosław , Wróbel Tomasz , Basak Grzegorz Władysław , Mądry Krzysztof , Snarski Emilian , Charliński Grzegorz , Frączak Ewa , Matuszkiewicz‐Rowińska Joanna , Klinger Marian , Augustyniak‐Bartosik Hanna , Krajewska Magdalena , Żebrowski Paweł , Król Maria , Urbanowska Elżbieta , Jurczyszyn Artur , Taszner Michał , Jędrzejczak Wieslaw Wiktor , Dwilewicz‐Trojaczek Jadwiga 
Published: September 2017

AbstractIntroductionHigh‐dose chemotherapy with autologous hematopoietic stem cell transplantation (auto‐HSCT) improves the outcome of patients with multiple myeloma (MM). It seems that auto‐HSCT is also a feasible therapeutic option in MM dialysis‐dependent (MMDD) patients. However, to perform transplantation, a sufficient number of stem cells must be collected.Materials and MethodsGiven that data on mobilization of auto‐HSC efficacy and safety in dialysis‐dependent patients are limited, we report data from all Polish Centers belonging to the Polish Myeloma Study Group. Twenty‐eight dialysis‐dependent MM‐patients were enrolled into this retrospective analysis. The study population comprised patients diagnosed between 2004 and 2015 in whom an attempt to collect auto‐HSC was made (68%: women, median age: 56). Patients received granulocyte‐colony stimulating factor (G‐CSF) alone or in combination with chemotherapy and autologous peripheral blood stem cells (auto‐PBSCs) were collected by leukapheresis.Results and ConclusionsThe success rate in terms of obtaining sufficient number of CD34(+) cells/kg for an auto‐HSCT (≥2 × 106 cells/kg body weight) during the first mobilization attempt was 92% (26/28 patients), and for 2 auto‐HSCTs (≥4 × 106 cells/kg) – was 75% (21/28 patients). After the second mobilization attempt (undertaken in 8 patients), a sufficient number of CD34(+)/kg cells for an auto‐HSCT was obtained for all patients and the number of CD34(+)/kg collected cells was sufficient for 2 auto‐HSCT in 6 additional patients. Hematologic toxicity and infections were the most frequent complications. Higher doses of cytarabine (>1.6 g/m2) and cyclophosphamide (> 2 g/m2) should be avoided in MMDD patients due to toxicity. Further studies are needed to establish mobilization regimens, confirm their safety, and dosing in MMDD patients.
Therapeutic plasma exchange in the treatment of complicated Plasmodium falciparum malaria: A case report
Authors: Ou Tsong‐Yih , Chuang Cheng‐Yen , Chen Chun‐Da , Cheng Chung‐Yi 
Published: September 2017

ABSTRACTSevere falciparum malaria is associated with multiple organ dysfunction and a high rate of fatal outcome. Malaria is a world‐wide disease in tropical areas through the bites of vector mosquitoes. Parasitic protozoans introduced by the mosquito's saliva to the blood travel to the liver then mature and reproduce. In humans, malaria is caused by Plasmodium falciparum, P. malariae, P. ovale, P. vivax, and P. knowlesi, and P. falciparum causes most deaths. Typical malaria symptoms include fever, chills, fatigue, headache, nausea, and vomiting. In severe cases, it can cause jaundice, seizures, coma, or death. Jaundice, caused by intravascular hemolysis is a usual complication of malaria, especially in patients with P. falciparum infection. The use of exchange transfusion in malaria is not currently advocated by the Centers of Disease Control and Prevention (CDC) of the United States of America. The role of therapeutic plasma exchange as an adjunctive therapy in malaria has not been widely discussed in the literature. Here, we present a 23‐year‐old patient with jaundice, acute renal failure, and cerebral involvement who was successfully treated with plasma exchange and hemodialysis.
Bridging Adult Experience to Pediatrics in Oncology Drug Development
Authors: Leong Ruby , Zhao Hong , Reaman Gregory , Liu Qi , Wang Yaning , Stewart Clinton F. , Burckart Gilbert 
Published: September 2017

AbstractPediatric drug development in the United States has grown under the current regulations made permanent by the Food and Drug Administration Safety and Innovation Act of 2012. Over 1200 pediatric studies have now been submitted to the US FDA, but there is still a high rate of failure to obtain pediatric labeling for the indication pursued. Pediatric oncology represents special problems in that the disease is most often dissimilar to any cancer found in the adult population. Therefore, the development of drug dosing in pediatric oncology patients represents a special challenge. Potential approaches to pediatric dosing in oncology patients include extrapolation of efficacy from adult studies in those few cases where the disease is similar, inclusion of adolescent patients in adult trials when possible, and bridging the adult dose to the pediatric dose. An analysis of the recommended phase 2 dose for 40 molecularly targeted agents in pediatric patients provides some insight into current practices. Increased knowledge of tumor biology and efforts to identify and validate molecular targets and genetic abnormalities that drive childhood cancers can lead to increased opportunities for precision medicine in the treatment of pediatric cancers.
Somatic Mutation Analysis of Human Cancers: Challenges in Clinical Practice
Authors: Tsongalis Gregory J. , Coleman William B. 
Published: September 2017

AbstractSomatic mutation analysis of human cancers has become the standard of practice. Whether screening for single gene variants or sequencing hundreds of cancer‐related genes, this genomic information is the basis for precision medicine initiatives in oncology. Genomic profiling results in information that allows oncologists to make a more educated selection of appropriate therapeutic strategies that more often combine traditional cytotoxic chemotherapy and radiation with novel targeted therapies. Here we discuss the nuances of implementing somatic mutation testing in a clinical setting.
White Diet with split‐dose Picosalax is preferred, better tolerated, and non‐inferior to day‐before clear fluids with polyethylene glycol plus sodium picosulfate‐magnesium citrate for morning colonoscopy: A randomized, non‐inferiority trial
Authors: Dwyer Jeremy P , Tan Jonathan Y C , Paul Eldho , Bunn Catherine , Mangira Dileep , Secomb Robyn , Gibson Peter R , Brown Gregor 
Published: September 2017

Background and AimBowel preparations with polyethylene glycol (PEG) and clear fluids are often poorly tolerated. We compared an innovative low‐residue White Diet and low‐volume, split‐dose Picosalax with the standard preparation at our institution of day‐before clear fluids and combination PEG plus sodium picosulfate/magnesium citrate (SPMC).MethodsAdults undergoing morning colonoscopy were randomized to either the White Diet and split‐dose, two sachets of Picosalax (WD/PICO) or day‐before clear fluids and 1‐L PEG plus two sachets of SPMC (CF/PEG + SPMC). The primary endpoint was successful bowel preparation defined by an Ottawa bowel preparation score ≤ 6. An intention‐to‐treat analysis with a predefined non‐inferiority margin of 15% was used to compare efficacy.ResultsA total of 250 patients were randomized (125 WD/PICO and 125 CF/PEG + SPMC). WD/PICO was non‐inferior to CF/PEG + SPMC for successful bowel preparation by intention‐to‐treat analysis (58% WD/PICO vs 62% CF/PEG + SPMC, 95%CI: −14.2 to 6.2%) and per‐protocol analysis (64% WD/PICO vs 65% CF/PEG + SPMC, 95%CI: −11.3 to 9.4%). Patients in the WD/PICO group reported greater satisfaction with the diet (P < 0.001), greater ease of following the diet (P < 0.001), and improved experience compared with prior colonoscopy (P < 0.0001), less bloating (P = 0.02), less weakness (P = 0.046), less hunger (P < 0.0001), and less interference with daily activities (P = 0.001). Procedure/withdrawal times and adenoma detection rates were similar between groups.ConclusionBowel preparation with the White Diet and low‐volume, split‐dose Picosalax was preferred and better tolerated without detriment to bowel preparation success compared with clear fluids and combination PEG plus SPMC for morning colonoscopy.
Regiospecific Isomerization of 2‐Benzoxazinon‐2‐yl Benzoic Acid Toward Some Nitrogen Nucleophiles as Environmental Insecticide
Authors: El‐Hashash Maher A. , Rizk Sameh A. , El‐Naggar Abeer M. , El‐Bana Mohamed G. 
Published: September 2017

Based on the strategies of receptor structure‐guided benzoxazinone design, a series of nitrogen nucleophiles such as benzyl amine, sodium azide, 4,4‐bis o‐toluidine, 4‐butanolamine, glucosamine, 2‐amino pyridine, 2‐picolinyl amine, hydroxyl amine, and hydrazine derivatives, for example, hydrazine hydrate, semicarbazide, thiosemicarbazide, methylhydrazide, phenylhydrazide, could be reacted with 2‐benzoxazine‐2‐yl benzoic acid 1. According the basicity of nucleophiles, regiospecific isomerization of benzoxazinone has been considered through formation of the spiro derivatives. Organic reagents can be controlled on the course of reaction of benzoxazinonyl benzoic acid 1. Preliminary bioassays indicated that the insecticidal spectra of the synthesized compounds were ecofriendly biodegradable materials due to isomerization. Among these analogues, the quinazoline 2–4 showed 100% mortality against Nilaparvata lugens (LC50 = 0.087 mg/L). The insecticidal potency of our designed analogues was dual‐controlled by isomerization to quinazolinone and spiro derivatives that observed in vitro and shed light on the novel insecticidal mechanism. The chemical structure of the products can be confirmed by microanalytical, spectral data, optimized and stimulated by quantum chemical parameters.
Who wins in the weaning process? Juvenile feeding morphology of two freshwater mussel species
Authors: Araujo Rafael , Campos Miquel , Feo Carles , Varela Catuxa , Soler Joaquín , Ondina Paz 
Published: September 2017

AbstractThe global decline of freshwater mussels can be partially attributed to their complex life cycle. Their survival from glochidium to adulthood is like a long obstacle race, with juvenile mortality as a key critical point. Mass mortality shortly after entering into a juvenile state has been reported in both wild and captive populations, thus weakening the effective bivalve population. A similar phenomenon occurs during metamorphosis in natural and hatchery populations of juvenile marine bivalves. Based on a morphological analysis using scanning electron microscopy of newly formed juveniles of the freshwater species Margaritifera margaritifera (L.) (Margaritiferidae) and Unio mancus Lamarck (Unionidae), we show that a second metamorphosis, consisting of drastic morphological changes, occurs that leads to suspension feeding in place of deposit feeding by the ciliated foot. We hypothesize that suspension feeding in these two species improves due to a gradual development of several morphological features including the contact between cilia of the inner gill posterior filaments, the inner gill reflection, the appearance of the ctenidial ventral groove and the formation of the pedal palps. Regardless of the presence of available food, a suspension feeding mode replaces deposit feeding, and juveniles unable to successfully transition morphologically or adapt to the feeding changes likely perish.
Dynamic contrast‐enhanced MRI in orbital lymphoproliferative disorders: Effects of region of interest selection methods on time efficiency, measurement reproducibility, and diagnostic ability
Authors: Qian Wen , Xu Xiao‐Quan , Hu Hao , Su Guo‐Yi , Wu Jiang‐Fen , Shi Hai‐Bin , Wu Fei‐Yun 
Published: September 2017

BackgroundPrevious studies indicated that dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) could serve as a useful biomarker for differentiating malignant from benign orbital lymphoproliferative disorders (OLPDs).PurposeTo investigate the influence of different region of interest (ROI) selection methods on the measurements of DCE‐MRI parameters, and their diagnostic ability in discriminating malignant from benign OLPDs.Study TypeRetrospective study.PopulationIn all, 46 patients with OLPDs (22 benign and 24 malignant).Field Strength/Sequence3.T DCE‐MRI using a 2D turbo fast low angle shot sequence postcontrast.AssessmentDCE‐MRI data were analyzed using three different ROI selection methods, including whole‐tumor ROI (ROIWT), single‐slice ROI (ROISS) and hot‐spot ROI (ROIHS). Quantitative parameters (Ktrans, Kep, Ve) were calculated based on a modified Tofts model.Statistical TestingAnalysis of variance test, intraclass correlation coefficient (ICC), Bland–Altman plots, independent t‐test, and receiver operating characteristic curve analyses were used for statistical analyses.ResultsThe time required for outlining ROIWT was significantly longer than ROISS and ROIHS (P < 0.001). The measurements of DCE‐MRI‐derived parameters based on ROIHS demonstrated lowest ICC, followed by ROISS and ROIWT. Malignant OLPDs showed significantly higher Kep than benign mimics (P < 0.001), while no significant differences were found on Ktrans (ROIWT, P = 0.535; ROISS, P = 0.557; ROIHS, P = 0.400) and Ve (ROIWT, P = 0.071; ROISS, P = 0.079; ROIHS, P = 0.057). Kep‐ROIWT showed the highest area under curve for differentiating malignant from benign OLPDs, followed by Kep‐ROISS, and Kep‐ROIHS; however, the differences were not significant (ROIWT vs. ROISS, P = 0.407; ROIWT vs. ROIHS, P = 0.363; ROISS vs. ROIHS, P = 0.887).Data ConclusionROI selection methods could have an influence on the measurements of DCE‐MRI parameters. Taking measurement time, reproducibility, and diagnostic ability into account, we suggest single‐slice ROI to be used for differentiating malignant from benign OLPDs in clinical practice.Level of Evidence: 3Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:1298–1305.
Evaluating instrument responsiveness in joint function: The HOOS JR, the KOOS JR, and the PROMIS PF CAT
Authors: Hung Man , Saltzman Charles L. , Greene Tom , Voss Maren W. , Bounsanga Jerry , Gu Yushan , Anderson Mike B. , Peters Christopher L. , Gililland Jeremy , Pelt Christopher E. 
Published: September 2017

ABSTRACT12345Responsiveness is the ability to detect change over time and is an important aspect of measures used to detect treatment effects. The purpose of this study was to assess the responsiveness of the HOOS JR, the KOOS JR, and the PROMIS Physical Function (PF) computerized adaptive test (CAT) in a joint reconstruction practice. 983 patients were evaluated for joint conditions between 2014 and 2017 in an orthopaedic clinic and completed the three instruments at baseline and 3 and/or 6‐month follow‐up visits. Average age was 61.03 years (SD = 12.33, Range = 18–90 years) and the majority of the patients were White (n = 875, 89.0%). Three‐month responsiveness was calculated two ways, as between 80 and 100 days and as 90 days and beyond. Six‐month responsiveness was calculated as 170–190 days and as 180 days and beyond. All changes from baseline scores were significant at the 3‐, >3‐, and >6‐month follow‐up (p < 0.05). All three measures showed large effect sizes, ranging from 0.80–1.20 at each time‐point. The standardized response mean was large for each measure and at each time‐point (Range = 1.06–1.53). This study demonstrated the responsiveness of the HOOS JR, KOOS JR, and the PROMIS PF in adult reconstruction patients. The PROMIS PF was consistently the most responsive instrument in this analysis. Clinical significance: The HOOS JR, KOOS JR, and PROMIS PF are useful clinical instruments for assessing treatment change and may be selected as relevant to the specific needs and conditions of the adult joint reconstruction patient population. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1178–1184, 2018.
The southern Norwegian Sea during the last 45 ka: hydrographical reorganizations under changing ice‐sheet dynamics
Authors: Wary Melanie , Eynaud Frederique , Rossignol Linda , Zaragosi Sebastien , Sabine Marjolaine , Castera Marie‐Helene , Billy Isabelle 
Published: September 2017

ABSTRACTThe last glacial millennial Heinrich and Dansgaard–Oeschger events have been the subject of many studies in recent decades. However, significant uncertainties remain, notably regarding associated oceanic mechanisms. Here we investigate the evolution of hydrographical conditions in the 3–41 ka cal BP interval of core MD99‐2285 located in the southern Norwegian Sea. Our results reveal an unusual scheme with: (i) warm Greenland interstadials marked by a relatively cold and homogeneous upper water column seasonally ice‐covered and active deep water formation, (ii) cold Greenland and Heinrich stadials marked by a warm, low‐salinity and nearly sea ice‐free surface layer with iceberg calving, separated by a strong halocline from a colder and saltier subsurface layer, as well as strongly reduced deep convection, and (iii) close to modern Holocene oceanic conditions, but showing significant differences from interstadial conditions. Hence, our work strongly suggests different deep‐water convection modes in the Nordic Seas, with, notably, interstadial deep water formation mainly forced by brine release. According to our results, the transition from the glacial mode of deep water formation to the modern open ocean convection mode might have occurred at the end of deglaciation/beginning of the Holocene, when both modes probably occurred.