bluuebunny/crossref_metadata_2025_split huggingface dataset:
In a Nutshell, or transforming childness through music across media: Maurice Sendak’s Nutshell Library and all the Really Rosies
Authors: Papazian Gretchen 
Published: October 2024

Abstract
Situated in several historical and scholarly contexts—Roland Barthes’s discussions of image/music/text, Michel Chion’s and Claudia Gorbman’s scholarship on film music, Linda Hutcheon’s (and others’) urgings to extend adaptation scholarship beyond book and film, and Kamilla Elliott’s call to disrupt the binaries of word/image literature/film—this article’s main intent is to look at the role music plays in adaptation. To do so, it focuses on Maurice Sendak’s 1962 Nutshell Library and the four concept books it contains (One was Johnny, Alligators All Around, Pierre, and Chicken Soup with Rice), these stories’ translation to television in 1975, and their subsequent transformation into a Broadway musical in 1980. The article argues for the value of looking to texts for children in relation to adaptation studies and especially with regard to music’s effects as a part of the adaptation process and product. As it does, it claims that, through music’s specific abilities to intensify emotion, position emphasis, and establish sequence, it transforms the literacy lessons of Sendak’s Nutshell Library, the ideologies of child agency put forward by that text, and the place of the real child in and in relation to media. In this, it highlights music’s capacity to disrupt and alter the word–image relationship across books, films, and embodied performance.
Reimagining and rebranding advance care planning
Authors: Malhotra Chetna 
Published: October 2024

Abstract
Advance care planning (ACP) has traditionally aimed at ensuring that patients’ end-of-life (EOL) wishes are understood and respected. However, recent literature raises concerns about its effectiveness, with many trials indicating that ACP does not significantly improve goal-concordant care, enhance quality of life or reduce healthcare costs. This is because patients’ future decisions are influenced by their transient preferences due to projection bias. To remain relevant, ACP requires a radical shift in perspective, implementation and branding. First, ACP’s mission must be redefined with a focus on: Educate, Share and Prepare. This perspective emphasises ongoing conversations about patient health and illness, sharing of patients’ current values and goals of care and preparation for the future, rather than making definitive future decisions. Second, ACP should be integrated into routine care, normalising these discussions. Simplifying ACP processes and shifting incentives to support shared responsibility among stakeholders can enhance integration. Last, rebranding ACP as ‘Advance Care Preparation’ can clarify its purpose, distinguishing it from EOL planning and increasing its uptake. This rebranding ensures that ACP meets the evolving needs of patients and their families, ultimately enhancing the quality of care and patient satisfaction. These changes in perspective, implementation and branding can transform ACP into a valuable tool for delivering compassionate, patient-centred healthcare, making it relevant to all individuals.
“Research happens a lot in other settings—so why not here?” A qualitative interview study of stakeholders’ views about advance planning for care home residents’ research participation
Authors: Nocivelli Brittany , Wood Fiona , Hood Kerenza , Wallace Carolyn , Shepherd Victoria 
Published: October 2024

Abstract

Background
Underrepresentation of care home residents in research has resulted in a poorer evidence base for health care in care homes. Fewer opportunities to take part in research, as well as assumptions made by others about their interest or wishes, creates challenges for residents’ inclusion in research. Early discussions about research preferences and wishes may be beneficial. This qualitative study aimed to explore stakeholders’ views about how care home residents can be supported to communicate their wishes about research participation.

Method
Semi-structured interviews were conducted with 25 stakeholders: care home residents (n = 5), relatives (n = 5), care home staff (n = 5), other health and social care professionals who work with care homes (n = 6), and care home researchers (n = 4). Interviews were conducted virtually or face-to-face and data were analysed using thematic analysis.

Results
Views about resident research participation, the barriers and facilitators to their inclusion, and the role of advance research planning were iteratively organized into three themes: (i) We’re of no value to research; (ii) Research is difficult; and (iii) Advance research planning: good in theory, challenging in practice. Subthemes were also identified, and findings were discussed with a Patient and Public Involvement group for additional reflections.

Conclusions
Stakeholders identified a number of barriers to including care home residents in research, including knowing their preferences about research. The development of interventions to facilitate communication that can be adapted to individuals’ requirements are needed to support discussions and decision-making with care home residents about wishes and preferences for future research participation.
Expanding the triangle of U: comparative analysis of the Hirschfeldia incana genome provides insights into chromosomal evolution, phylogenomics and high photosynthesis-related traits
Authors: Hoang Nam V , Walden Nora , Caracciolo Ludovico , Luoni Sofia Bengoa , Retta Moges , Li Run , Wolters Felicia C , Woldu Tina , Becker Frank F M , Verbaarschot Patrick , Harbinson Jeremy , Driever Steven M , Struik Paul C , van Amerongen Herbert , de Ridder Dick , Aarts Mark G M , Schranz M Eric 
Published: October 2024

Abstract

Background and Aims
The Brassiceae tribe encompasses many economically important crops and exhibits high intra- and interspecific phenotypic variation. After a shared whole-genome triplication (WGT) event (Br-α, ~15.9 Mya), differential lineage diversification and genomic changes contributed to an array of divergence in morphology, biochemistry and physiology underlying photosynthesis-related traits. Here, the C3 species Hirschfeldia incana is studied because it displays high photosynthetic rates in high-light conditions. Our aim was to elucidate the evolution that gave rise to the genome of H. incana and its high-photosynthesis traits.

Methods
We reconstructed a chromosome-level genome assembly for H. incana (Nijmegen, v.2.0) using nanopore and chromosome conformation capture (Hi-C) technologies, with 409 Mb in size and an N50 of 52 Mb (a 10× improvement over the previously published scaffold-level v.1.0 assembly). The updated assembly and annotation were subsequently used to investigate the WGT history of H. incana in a comparative phylogenomic framework from the Brassiceae ancestral genomic blocks and related diploidized crops.

Key Results
Hirschfeldia incana (x = 7) shares extensive genome collinearity with Raphanus sativus (x = 9). These two species share some commonalities with Brassica rapa and Brassica oleracea (A genome, x = 10 and C genome, x = 9, respectively) and other similarities with Brassica nigra (B genome, x = 8). Phylogenetic analysis revealed that H. incana and R. sativus form a monophyletic clade in between the Brassica A/C and B genomes. We postulate that H. incana and R. sativus genomes are results of hybridization or introgression of the Brassica A/C and B genome types. Our results might explain the discrepancy observed in published studies regarding phylogenetic placement of H. incana and R. sativus in relationship to the ‘triangle of U’ species. Expression analysis of WGT retained gene copies revealed sub-genome expression divergence, probably attributable to neo- or sub-functionalization. Finally, we highlight genes associated with physio-biochemical–anatomical adaptive changes observed in H. incana, which are likely to facilitate its high-photosynthesis traits under high light.

Conclusions
The improved H. incana genome assembly, annotation and results presented in this work will be a valuable resource for future research to unravel the genetic basis of its ability to maintain a high photosynthetic efficiency in high-light conditions and thereby improve photosynthesis for enhanced agricultural production.
Manipulation of the Nasal Superficial Musculoaponeurotic System to Enhance Midvault and Supratip Contouring
Authors: Glener Adam D , Bailey Virginia E , Sheen Derek , Cochran Spencer 
Published: October 2024

Abstract

Background
Management of dorsal dead space and the aesthetics of a supratip break are paramount to achieving reproducible and reliable results in rhinoplasty.

Objectives
The authors present a modified technique of redraping the nasal soft tissue envelope in structural rhinoplasty by utilizing the nasal superficial musculoaponeurotic system (SMAS) to help obliterate dorsal dead space and restore normal anatomy, thereby enhancing midvault and supratip contouring.

Methods
A standard open rhinoplasty approach is utilized. A planar transition from supraperichondrial to subperichondrial/subperiosteal is completed during the dorsal dissection. The open structural rhinoplasty then proceeds as previously published by the senior author. After any desired tip work is completed, the cephalically based SMAS layer is reconstituted with suture fixation laterally along the caudal border of the upper lateral cartilages. A more robust technical discussion is borne out in the manuscript.

Results
At submission, the senior author has performed &gt;100 rhinoplasties employing this technique over roughly 1 year. Subjectively, patients have had better immediate supratip contour with less residual dorsal soft tissue edema. A case example with photographs is included at a 1 year postoperative time point.

Conclusions
Using this described technique, surgeons can employ an open, structural, approach to rhinoplasty while using restoration of natural anatomy to achieve a refined postoperative result, accentuating supratip break while minimizing dorsal soft tissue dead space.

Level of Evidence: 5 (Therapeutic)
The Social Area of the Breast: An Evolution Through Cultures and Centuries
Authors: Bagdia Amitkumar M , Rocco Nicola , Catanuto Giuseppe , Calenda Fabrizia , Buccheri Ernesto , Villanucci Amedeo , Bagdia Madhusudan S , Koppiker Chaitanyanand , Nava Maurizio Bruno 
Published: October 2024

Abstract
Breasts have evolved as a functional and aesthetic unit. The perception of society toward social exposure of the breast has been extremely diverse, not only temporally through the same civilization but also among contemporary parallel societies in geographically diverse areas. This article explores the spatial and temporal evolution of the outlook toward social exposure of breast over the past 3000 years among different societies, countries, and religions. The level of “acceptance” or “tolerance” toward visibility of breast in social situations was historically guided by social conditioning. Recently, the personal attitudes and preferences of the women themselves have become more deterministic of the clothing choices. Consequently, the conventional oncoplastic notion of a “no-scar zone” being the upper-inner quadrant of the breast must also be redefined to match the dynamic personal preferences of the patient. It is important to know what the patient thinks is the “most social” area of the breast for her, and then to avoid scars in those areas if possible. The article discusses the quest to minimize scars and the importance of shared decision making.
Forecasting dominance of SARS-CoV-2 lineages by anomaly detection using deep AutoEncoders
Authors: Rancati Simone , Nicora Giovanna , Prosperi Mattia , Bellazzi Riccardo , Salemi Marco , Marini Simone 
Published: October 2024

Abstract
The COVID-19 pandemic is marked by the successive emergence of new SARS-CoV-2 variants, lineages, and sublineages that outcompete earlier strains, largely due to factors like increased transmissibility and immune escape. We propose DeepAutoCoV, an unsupervised deep learning anomaly detection system, to predict future dominant lineages (FDLs). We define FDLs as viral (sub)lineages that will constitute &gt;10% of all the viral sequences added to the GISAID, a public database supporting viral genetic sequence sharing, in a given week. DeepAutoCoV is trained and validated by assembling global and country-specific data sets from over 16 million Spike protein sequences sampled over a period of ~4 years. DeepAutoCoV successfully flags FDLs at very low frequencies (0.01%–3%), with median lead times of 4–17 weeks, and predicts FDLs between ~5 and ~25 times better than a baseline approach. For example, the B.1.617.2 vaccine reference strain was flagged as FDL when its frequency was only 0.01%, more than a year before it was considered for an updated COVID-19 vaccine. Furthermore, DeepAutoCoV outputs interpretable results by pinpointing specific mutations potentially linked to increased fitness and may provide significant insights for the optimization of public health ‘pre-emptive’ intervention strategies.
Cell cycle expression heterogeneity predicts degree of differentiation
Authors: Noller Kathleen , Cahan Patrick 
Published: October 2024

Abstract
Methods that predict fate potential or degree of differentiation from transcriptomic data have identified rare progenitor populations and uncovered developmental regulatory mechanisms. However, some state-of-the-art methods are too computationally burdensome for emerging large-scale data and all methods make inaccurate predictions in certain biological systems. We developed a method in R (stemFinder) that predicts single cell differentiation time based on heterogeneity in cell cycle gene expression. Our method is computationally tractable and is as good as or superior to competitors. As part of our benchmarking, we implemented four different performance metrics to assist potential users in selecting the tool that is most apt for their application. Finally, we explore the relationship between differentiation time and cell fate potential by analyzing a lineage tracing dataset with clonally labelled hematopoietic cells, revealing that metrics of differentiation time are correlated with the number of downstream lineages.
Measuring and Explaining Situational Fear of Crime: An Experimental Study Into the Effects of Disorder, Using Virtual Reality and Multimodal Measurement
Authors: Brands Jelle , Jansen Jochem Milan , van Doorn Janne , Spithoven Remco 
Published: October 2024

Abstract
The current study combines an experimental research design, Virtual Reality (VR) and multimodal (survey and physiological) measurements to measure and explain situational fear of crime. 159 participants completed our VR experiment in which we focused on the role of physical and social disorder in engendering situational fear of crime. Drawing on our survey measures, we find significant effects of disorder on a variety of outcome variables: situationally experienced safety, fear of theft, fear of verbal aggression, fear and physical aggression and fear of sexually transgressive behaviour. Most of our physiological measures rendered null findings. Hence, we also conclude that the results from our two data sources (survey measures vs. physiological measures) diverge in important ways.
Association of Upper Gastrointestinal Surgery of Great Britain and Ireland (AUGIS)/perioperative quality initiative (POQI) consensus statement on prehabilitation in oesophagogastric surgery
Authors: Walker Robert C , Barman Sowrav , Pucher Philip H , Singh Pritam , Whyte Greg , Moore John , Huddy Fiona , Evans Orla , Tham Gemma , Noor Z Zainab , Hussey Juliette , West Malcolm A , Jack Sandy , Levett Denny , Underwood Timothy J , Gossage James A , Sultan Javed , Maynard Nicholas , Miller Timothy E , Grocott Michael P W , Davies Andrew R ,   AUGIS/POQI Prehabilitation Consensus Group, Davies Andrew , Walker Rob , Barman Sowrav , Pucher Philip , Singh Pritam , Miller Timothy E , Grocott Michael P W , Brown Rachel , Browning Mike , Butler Katrina , Evans Orla , Gossage James , Guinan Emer , Huddy Fiona , Hussey Juliette , Jack Sandy , Noor Zainab , Levett Denny , Markar Sheraz , Maynard Nick , Moore John , Moorthy Krishna , Pate Jim , Peters Christopher , Phillips Alexander , Preston Shaun , Skipworth Richard , Sultan Javed , West Malcolm , Whyte Greg , Wijnhoven Bas 
Published: October 2024

Abstract

Background
Prehabilitation is safe, feasible and may improve a range of outcomes in patients with oesophago-gastric cancer (OGC). Recent studies have suggested the potential of prehabilitation to improve body composition, sarcopenia and physical fitness, reduce surgical complications and improve quality of life. Despite this, prehabilitation services are not offered throughout all OGC centres in the UK. Where prehabilitation is offered, delivery and definitions vary significantly, as do funding sources and access.

Methods
A professional association endorsed series of consensus meetings were conducted using a modified Delphi process developed by the Peri-Operative Quality Initiative (POQI) to identify and refine consensus statements relating to the development and delivery of prehabilitation services for OGC patients. Participants from a variety of disciplines were identified based on a track record of published studies in the field of prehabilitation and/or practice experience encompassing prehabilitation of OGC patients. Approval from the POQI board was obtained and independent supervision provided by POQI.

Results
A total of 20 statements were developed and agreed by 26 participants over a preliminary meeting and 2 semi-structured formal POQI meetings. Ten research themes were identified. In the case of one statement, consensus was not reached and the statement was recorded and developed into a research theme. A strong recommendation was made for the majority of the consensus statements (17 of 20).

Discussion
Consensus statements encompassing the interventions and outcomes of prehabilitation services in oesophago-gastric cancer surgery have been developed to inform the implementation of programmes.
Radiosurgery versus observation for brainstem cavernous malformations: a 5-year multicentre cohort study
Authors: Li Da , Weng Jian-Cong , Sun Shi-Bin , Zhang Gui-Jun , Yao Bo-Han , Wang Guo-Kai , Chen Jing , Feng Shou-Xin , Liu Hai-Tao , Zhou Fu-Gui , Liu Pan-Pan , Kong Lu , Zhou Hui , Zhang Hao-Yu , Zeng Xiao-Jun , Wu Ze-Yu , Lin Jiu-Luan , Ren Cong , Wang Wei , Zhang Hong-Jun , Xu Xiao-Ying , Song Lai-Rong , Du Xin , Wang Liang 
Published: October 2024

Abstract
The role of radiosurgery in preventing haemorrhage in brainstem cavernous malformations remains a subject of debate. This study aimed to evaluate whether radiosurgery provides a protective benefit against haemorrhage in these patients. This multicentre, prospective observational study was conducted in 17 centres and enrolled eligible patients with brainstem cavernous malformations consecutively. Data collected included clinical baseline information, radiosurgery planning details, periodic follow-up evaluations and any adverse radiation effects. The primary outcome of the study was the incidence of first prospective haemorrhage, and the secondary outcome was the development of new or worsening neurological dysfunctions. The impact of radiosurgery was assessed using multivariate Cox regression analysis. From March 2016 to August 2018, the study enrolled 377 patients: 280 in the observation group receiving standard care alone and 97 in the radiosurgery group receiving both radiosurgery and standard care. The overall cohort consisted of 173 females (45.9%) with a mean age of 40.5 years (range, 18–68 years), and there were no significant differences in baseline characteristics between the two groups. After a median follow-up period of 70 months, haemorrhage occurred in 25.0% (n = 70) of patients in the observation group and 10.3% (n = 10) of patients in the radiosurgery group. Multivariate Cox regression analysis identified radiosurgery as an independent protective factor against haemorrhage (hazard ratio 0.379, 95% confidence interval 0.195–0.738, P = 0.004). Following 1:2 propensity score matching, the incidence of prospective haemorrhage was 24.9% (45/181) in the observation group compared with 10.3% (10/97) in the radiosurgery group (hazard ratio 0.379, 95% confidence interval 0.190–0.755, P = 0.006). Adverse radiation effects were observed in 12 patients (12.4%), with none being permanent. Additionally, new or worsening neurological dysfunctions were significantly more common in the observation group (28.9%) compared with the radiosurgery group (16.5%) (P = 0.016). These results suggest that radiosurgery is associated with a low rate of haemorrhage in patients with brainstem cavernous malformations and could provide a benefit in selected patients. However, further research is required to confirm these findings.
White matter protection with insulin-like growth factor-1 after hypoxia-ischaemia in preterm foetal sheep
Authors: Wassink Guido , Cho Kenta H T , Mathai Sam , Lear Christopher A , Dean Justin M , Gunn Alistair J , Bennet Laura 
Published: October 2024

Abstract
Perinatal hypoxia-ischaemia in extremely preterm infants is associated with long-term neurodevelopmental impairment, for which there is no specific treatment. Insulin-like growth factor-1 can reduce acute brain injury, but its effects on chronic white matter injury after hypoxia-ischaemia are unclear. Preterm-equivalent foetal sheep (0.6 gestation) received either sham-asphyxia or asphyxia induced by umbilical cord occlusion for 30 min, and recovered for either 3 or 35 days after asphyxia. The 35 day recovery groups received either an intracerebroventricular infusion of insulin-like growth factor-1 (1 µg/24 h) or vehicle, from 3 to 14 days after asphyxia. Asphyxia was associated with ventricular enlargement, and loss of frontal and parietal white matter area (P &lt; 0.05 versus sham-asphyxia). This was associated with reduced area fraction of myelin basic protein and numbers of oligodendrocyte transcription factor 2 and mature, anti-adenomatous polyposis coli-positive oligodendrocytes in periventricular white matter (P &lt; 0.05), with persistent inflammation and caspase-3 activation (P &lt; 0.05). Four of eight foetuses developed cystic lesions in temporal white matter. Prolonged infusion with insulin-like growth factor-1 restored frontal white matter area, improved numbers of oligodendrocyte transcription factor 2-positive and mature, anti-adenomatous polyposis coli-positive oligodendrocytes, with reduced astrogliosis and microgliosis after 35 days recovery (P &lt; 0.05 versus asphyxia). One of four foetuses developed temporal cystic lesions. Functionally, insulin-like growth factor-1-treated foetuses had faster recovery of EEG power, but not spectral edge. Encouragingly, these findings show that delayed, prolonged, insulin-like growth factor-1 treatment can improve functional maturation of periventricular white matter after severe asphyxia in the very immature brain, at least in part by suppressing chronic neural inflammation.
Umpolung of 4,4-disubstituted 2-hydroxycyclohexa-2,5-dienones for the regiodivergent synthesis of disubstituted catechols
Authors: Akazawa Ryunosuke , Mohamed Ahmed A B , Yahata Kenzo , Miyagaki Kohei , Togami Masaki , Sawama Yoshinari , Kanomata Kyohei , Akai Shuji 
Published: October 2024

Abstract
The umpolung of 4,4-disubstituted 2-hydroxycyclohexa-2,5-dienones 1 with PhI(OCOCF3)2 achieved the migration into the more electron-rich C3 position, providing exclusively 3,4-disubstituted catechols 3. Acid-induced rearrangement of 1 produced 4,5-disubstituted catechols 2. These two reactions enabled the highly selective production of two regioisomers of disubstituted catechols, especially biaryls containing catechol moieties, from the common intermediates 1.