bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors
Authors: de Veer Simon J. , Swedberg Joakim E. , Brattsand Maria , Clements Judith A. , Harris Jonathan M. 
Published: February 2016

Abstract
Kallikrein-related peptidase 5 (KLK5) is a promising therapeutic target in several skin diseases, including Netherton syndrome, and is emerging as a potential target in various cancers. In this study, we used a sparse matrix library of 125 individually synthesized peptide substrates to characterize the binding specificity of KLK5. The sequences most favored by KLK5 were GRSR, YRSR and GRNR, and we identified sequence-specific interactions involving the peptide N-terminus by analyzing kinetic constants (k
cat and K
M) and performing molecular dynamics simulations. KLK5 inhibitors were subsequently engineered by substituting substrate sequences into the binding loop (P1, P2 and P4 residues) of sunflower trypsin inhibitor-1 (SFTI-1). These inhibitors were effective against KLK5 but showed limited selectivity, and performing a further substitution at P2′ led to the design of a new variant that displayed improved activity against KLK5 (K
i=4.2±0.2 nm), weak activity against KLK7 and 12-fold selectivity over KLK14. Collectively, these findings provide new insight into the design of highly favored binding sequences for KLK5 and reveal several opportunities for modulating inhibitor selectivity over closely related proteases that will be useful for future studies aiming to develop therapeutic molecules targeting KLK5.
Risk Management Optimization for Sovereign Debt Restructuring
Authors: Consiglio Andrea , Zenios Stavros A. 
Published: February 2016

AbstractDebt restructuring is one of the policy tools available for resolving sovereign debt crises and, while unorthodox, it is not uncommon. We propose a scenario analysis for debt sustainability and integrate it with scenario optimization for risk management in restructuring sovereign debt. The scenario dynamics of debt-to-GDP ratio are used to define a tail risk measure, termedconditional Debt-at-Risk. A multi-period stochastic programming model minimizes the expected cost of debt financing subject to risk limits. It provides an operational model to handle significant aspects of debt restructuring: it collects all debt issues in a common framework, and can include contingent claims, multiple currencies and step-up or linked contractual features. Alternative debt profiles – obtained by maturity rescheduling, interest payment concessions or nominal value haircuts – are analyzed for their expected cost-risk tradeoffs. With a suitable re-calculation of the efficient frontier, the risk of debt un-sustainability of alternative risk profiles can be ascertained with a given confidence level. The model is applied to Greece sovereign debt crisis analyzing the suitability of various proposals to restore debt sustainability.
An efficient computer based wavelets approximation method to solve Fuzzy boundary value differential equations
Authors: Alam Khan Najeeb , Razzaq Oyoon Abdul 
Published: February 2016

AbstractIn the present work a wavelets approximation method is employed to solve fuzzy boundary value differential equations (FBVDEs). Essentially, a truncated Legendre wavelets series together with the Legendre wavelets operational matrix of derivative are utilized to convert FB- VDE into a simple computational problem by reducing it into a system of fuzzy algebraic linear equations. The capability of scheme is investigated on second order FB- VDE considered under generalized H-differentiability. Solutions are represented graphically showing competency and accuracy of this method.
Homotopy Perturbation Transform Method with He’s Polynomial for Solution of Coupled Nonlinear Partial Differential Equations
Authors: Sharma Dinkar , Singh Prince , Chauhan Shubha 
Published: February 2016

AbstractIn this paper, a combined form of the Laplace transform method with the homotopy perturbation method (HPTM) is applied to solve nonlinear systems of partial differential equations viz. the system of third order KdV Equations and the systems of coupled Burgers’ equations in one- and two- dimensions. The nonlinear terms can be easily handled by the use of He’s polynomials. The results shows that the HPTM is very efficient, simple and avoids the round-off errors. Four test examples are considered to illustrate the present scheme. Further the results are compared with Homotopy perturbation method (HPM) which shows that this method is a suitable method for solving systems of partial differential equations.
A magnetic nanosorbent for cesium removal in aqueous solutions
Authors: Zhao Liang , Dudek Jakub , Polkowska-Motrenko Halina , Chmielewski Andrzej G. 
Published: February 2016

Abstract
The composite of magnetic Fe(hydr) Oxide and cobalt potassium ferrocyanide with excellent adsorption capacity of cesium has been
prepared by chemical coprecipitation method. The results of structural testing confirm the successful preparation of magnetic material
K2[CoFe(CN)6]. It is applied as adsorbent for the separation of cesium from water solution. At pH 7 and
293 K, the maximum adsorption capacity for cesium can achieve to 141.44 mg/g. Adsorption of cesium on magnetic
K2[CoFe(CN)6] surface is an spontaneous process. The as-synthesized adsorbent can be separated from aqueous solution in
the magnetic field. The results of adsorption process show that it has the potential to be an effective adsorbent for practical use.
Emerging trends in eco-compliant, synergistic, and hybrid assembling of multifunctional polymeric bionanocomposites
Authors: Idumah Christopher Igwe , Hassan Azman 
Published: February 2016

AbstractThe quest to develop eco-benign polymeric hybrid materials arose out of the need to protect the environment from the harmful effects of synthetic petroleum polymeric waste and meet the specific needs of industries such as oil and gas, aerospace, automotives, packaging, electronics biomedicals, pharmaceuticals, agricultural, and construction. This has resulted in synergistic hybrid assembling of natural fibers, polymers, biopolymers, and nanoparticles. Bionanocomposites based on inorganic nanoparticle reinforced biofiber, polymers and biopolymers, and polysaccharides such as chitosan, alginate, and cellulose derivatives, and so on, exhibiting at least a dimension at the nanometer scale, are an emerging group of nanostructured hybrid materials. These hybrid bionanocomposites exhibit structural and multifunctional properties suitable for versatile applications similar to polymer nanocomposites. Their biocompatibility and biodegradability provide opportunities for applications as eco-benign green nanocomposites. This review presents state-of-the-art progress in synergistic nanotechnological assembling of bionanocomposites relative to processing technologies, product development, and applications.
pNET co-secreting GHRH and calcitonin: ex vivo hormonal studies in human pituitary cells
Authors: Zornitzki Taiba , Rubinfeld Hadara , Lysyy Lyudmila , Schiller Tal , Raverot Véronique , Shimon Ilan , Knobler Hilla 
Published: February 2016

Summary
Acromegaly due to ectopic GHRH secretion from a neuroendocrine tumor (NET) is rare and comprises <1% of all acromegaly cases. Herein we present a 57-year-old woman with clinical and biochemical features of acromegaly and a 6 cm pancreatic NET (pNET), secreting GHRH and calcitonin. Following surgical resection of the pancreatic tumor, IGF1, GH and calcitonin normalized, and the clinical features of acromegaly improved. In vitro studies confirmed that the tumor secreted large amounts of both GHRH and calcitonin, and incubation of pNET culture-derived conditioned media stimulated GH release from a cultured human pituitary adenoma. This is a unique case of pNET secreting both GHRH and calcitonin. The ability of the pNET-derived medium to stimulate in vitro GH release from a human pituitary-cell culture, combined with the clinical and hormonal remission following tumor resection, confirmed the ectopic source of acromegaly in this patient.

Learning points

Signs, symptoms and initial work-up of acromegaly due to ectopic GHRH secretion are similar to pituitary-dependent acromegaly. However, if no identifiable pituitary lesion is found, somatostatin receptor scan and further imaging (CT, MRI) should be performed.

Detection of GHRH in the blood and in the tumor-derived medium supports the diagnosis of ectopic GHRH secretion.

Functional bioactivity of pNET-secreted GHRH can be proved in vitro by releasing GH from human pituitary cells.
A Virtual Standoff – Using Q Methodology to Analyze Virtual Reference
Authors: Shrimplin Aaron , Hurst Susan 
Published: February 2016

Abstract

Objective - To develop an exploratory understanding of reference librarians’ perceptions of virtual reference.

Methods – Q methodology was used to uncover points of view about virtual reference. Thirty-four librarians sorted 28 statements covering a wide range of opinions about virtual reference. Factor analysis was used to analyze the Q-sorts and factor scores were calculated to aid the task of understanding and interpretation.

Results - The factor analysis revealed three attitudinal typologies: Technophiles, Traditionalists, and Pragmatists. Each factor represents a group of reference librarians who think similarly about virtual reference.

Conclusions - This type of analysis provides data on the actual range of feelings and attitudes about providing virtual reference services. The factor analysis demonstrates that there are still a variety of strongly held viewpoints concerning virtual reference. Convergence towards either acceptance or rejection does not appear to be forthcoming.
By using this type of analysis and the resulting data as a basis for decision making, administrators could staff services more efficiently and with the resulting better fit between librarians and their positions, possibly increase morale.
Further Research is Required to Determine Which Database Products Best Support Research in Public Administration
Authors: Hook David 
Published: February 2016

A review of:

Tucker, James, Corey. “Database Support for Research in Public Administration.” Behavioral & Social Sciences Librarian 24.1 (2005): 47-60.

Objective – To examine the extent to which six commercial database products support student and faculty research in the area of public administration.

Design – Bibliometric study.

Setting – Academic library in the United States.

Subjects – Six commercial business-related database products were examined: Proquest’s ABI/INFORM Global edition (ABI), EBSCO’s Business Source Premier (BSP), Gale’s General BusinessFile ASAP (GBF), EBSCO’s Academic Search Premier (ASP), EBSCO’s Expanded Academic Index (EAI) and Proquest’s International Academic Research Library (ARL). Three of the databases (ABI, BSP, GBF) were chosen because they address the management, human resource, and financing elements of public administration. The other three (ASP, EAI, ARL) were included because of their multidisciplinary coverage.

Methods – A list of journal titles covering public administration was assembled from the Institute of Scientific Information’s Social Sciences Citation Index and previously published lists of recommended journals in the field. The author then compared the compiled list of journal titles against the journal titles indexed by the six database
products. He further analyzed the results by level of journal coverage (abstract only, full-text, and full-text with embargo) and subject area based on categories described in Ulrich’s Periodicals Directory.

Main Results – The study found that three of the six database products --EAI, BSP, and ARL -- provide indexing for the greatest number of public administration journals contained in the compiled list. EIA and ARL cover the greatest number of those that are full-text journals, while BSP and ASP cover the greatest number of those full-text journals limited by publisher embargoes.

Conclusion – The author concludes that of the six databases examined, EAI, BSP, and ARL are the best for public administration research, based on their strength in the subject areas of public administration and public finance. The author also recommends that librarians in the field of public administration “carefully evaluate each database to see which one best fits the needs of the library and patrons” (56).
EBLIG Report: Interest Group Meets in Atlantic Canada and New Co-convenors are Chosen
Authors: Wilson Virginia , Currie Lyn 
Published: February 2016

May was a month of travel for many Evidence-Based Librarianship Interest Group (EBLIG) members. From May 6 – 11, the 4th International Evidence Based Library and Information Practice conference was held in Durham-Chapel Hill, North Carolina. From May 22 – 26, EBLIG members attended the Canadian Library Association (CLA) conference in St. John’s, Newfoundland. As the second anniversary of the formation of EBLIG has come around, the inaugural co-conveners, Lyn Currie and Virginia Wilson, are wrapping up their two-year term. Congratulations to Sue Fahey of Memorial University of Newfoundland and Renée deGannes, Canadian Dental Association, Ottawa, who have taken over the reins and accepted a two-year term as EBLIG’s new co-conveners.

EBLIG has been active this past year, mainly in the area of conference workshops and sessions. At the organizers’ invitation, we successfully submitted and presented a half-day post-conference workshop for the 4th International Evidence Based Librarianship Conference. How to Assess the Evidence: A Critical Appraisal Tool for Library and Information Research, facilitated by Lindsay Glynn, of Memorial University of Newfoundland, was an extremely well-received session with nearly 30 participants in attendance.

Virginia Wilson and Stephanie Hall created a practical toolkit on evidence-based library and information practice specifically for public librarians: http://ebltoolkit.pbwiki.com/. This toolkit was unveiled at the 2007 CLA conference in St. John’s by Stephanie Hall.

A wiki was launched in 2007 entitled eblibrarianship: the Wiki of the Evidence Based Librarianship Interest Group (EBLIG) to facilitate interest group collaboration, sharing, and information access, as well as a means of communication: http://eblibrarianship.pbwiki.com/

EBLIG members are active in the EBLIP community and beyond:

EBLIG members edited and contributed to an EBL-themed issue of Feliciter.
EBLIG members are participating as editors, on the editorial advisory board, and on the evidence summary team of the open access journal, Evidence Based Library and Information Practice.
As a result of a posting on the eblibrarianship wiki for the CLA conference session, Evidence-Based Librarianship: A Toolkit for Public Libraries, Virginia Wilson and Stephanie Hall have been invited to present a 1-hour audio conference for the Education Institute in the fall of 2007.

International membership to the interest group is available without having to become a full member of CLA. For only $30 CAD, people residing outside of Canada can join EBLIG and take advantage of networking and continuing education opportunities. More information on international membership is available at http://www.cla.ca/about/igroups/evidence_based.htm.

The past two years have been challenging and exciting. An active and engaged membership goes a long way in making this interest group vital and productive.
There is a Significant Relationship Between Computer Attitudes and Library Anxiety Among African American Graduate Students
Authors: Needham Gill 
Published: February 2016

Objective – To investigate whether African American students’ computer attitudes predict levels of library anxiety.

Design – A user study in which two instruments were administered to a group of graduate students to measure computer attitudes and library anxiety.

Setting – The College of Education at an historically black college and university in the United States of America.

Subjects – Ninety-four, predominantly female, African American graduate students, ranging in age from 22-62 years old, and enrolled in either a statistics or a measurement course.

Methods – Two instruments, the Computer Attitude Scale (CAS) and the Library Anxiety Scale (LAS) were administered to all the study participants. The Computer Anxiety Scale contains forty Likert-type items that assess individuals’ attitudes toward computers and their use. It includes four scales which can be administered separately:

1.	Anxiety or fear of computers
2.	Confidence in the ability to use computers
3.	Liking or enjoying working with computers
4.	Computer usefulness

The LAS contains forty-three, 5-point, Likert-format items that assess levels of library anxiety experienced by college students. It also has five subscales as follows:

1.	Barriers with staff
2.	Affective barriers
3.	Comfort with the library
4.	Knowledge of the library
5.	Mechanical barriers

Main results – There were twenty correlations between the library anxiety subscale scores and the computer attitude subscale scores. Four of these correlations were statistically significant. Liking or enjoying working with computers was statistically significantly linked to affective barriers, comfort with the library, and knowledge of the library. There was also a statistically significant association between an attitude of computer usefulness and knowledge of the library.

Conclusion – These findings suggest that in this group of students there is a medium to strong relationship between computer attitudes and library anxiety.
Evolución del cooperativismo de consumo
Authors: Martínez Charterina Alejandro 
Published: February 2016

<p>La cooperativa de consumo se sitúa en el origen del cooperativismo moderno. A lo largo del tiempo se han producido muchos cambios, en algunos momentos muy intensos y muy rápidos, y han afectado a la marcha y existencia de las cooperativas de consumo. Estas han evolucionado para profundizar en su servicio y mantener su sentido. Se examina con detenimiento el caso de la cooperativa Eroski, que con origen en el País Vasco extiende su actividad y se sitúa entre las grandes sociedades de distribución siguiendo un nuevo modelo, y se fija la atención también en una cooperativa local, de barrio, la Park Slope Food Coop de Brooklyn, como una alternativa. En ambos casos el consumidor, su formación y la defensa de sus derechos son de la máxima importancia. </p><strong>Recibido</strong>: 16.06.11<br /><strong>Aceptado</strong>: 05.07.11
La función económica de la cooperativa y la necesidad de una legislación adecuada
Authors: Gadea Soler Enrique 
Published: February 2016

<p>El objetivo de este trabajo es doble: por una parte, se analiza el origen histórico y la función económica actual de las sociedades cooperativas y, por otra, se realiza un estudio crítico de su normativa aplicable, con el objeto de determinar las bases de la futura legislación. </p><p><strong>Recibido</strong>: 31.05.11<br /><strong>Aceptado</strong>: 05.07.11</p>
La actualidad institucional y económica de España en el marco de la Unión Europea
Authors: Iñarritu Beatriz 
Published: February 2016

<p><strong>Sumario:</strong> I. Introducción.—II. El Estado de la Integración. 1. Debate en el Reino Unido en relación a la Unión Europea. 2. Islandia retira su solicitud de adhesión a la UE. 3. Gobernanza económica: el Semestre Europeo 2015. 4. Debate sobre la gobernanza económica europea: la ambiciosa propuesta española. 5. Acuerdo político sobre el Plan Juncker. 6. La Comisión propone una multa a España por el falseamiento del déficit público.— III. Cuestiones generales de la actualidad económica. 1. BCE: Compra masiva de Deuda pública. 2. Mecanismo Europeo de Estabilidad: primera emisión de deuda con intereses negativos. 3. Acuerdo Trasatlántico UEEEUU: negociaciones pospuestas. 4. Competencia-ayudas públicas: investigación sobre las ayudas a las compañías eléctricas de once países y al sector bancario de cuatro países. 5. Competencia-abuso de posición de dominio: acusaciones a Google y Gazprom. 6. Bruselas recurre la decisión del Tribunal sobre las deducciones fiscales aplicadas por empresas españolas por la adquisición de empresas extranjeras. 7. Tribunal de Justicia: nuevo dictamen en contra de la Ley Hipotecaria española. 8. Competencia: autorización de compra de Jazztel por parte de Orange. 9. Inmigración: plan de acogida a solicitantes de asilo.</p>
Espacio judicial autonómico
Authors: Zorrilla Ruiz Manuel María 
Published: February 2016

1. Dimensión institucional de las Comunidades Autónomas del Estado compuesto. 2. Significado de la organización judicial en el marco territorial de las Comunidades Autónomas. 3. Acciones racionalizadoras de las Comunidades Autónomas. 4. Justificación y prevalencia del principio de unidad jurisdiccional. 5. ¿Traslaciones anejas a un poder judicial autonómico?. 6. Peripecias del planteamiento del problema. 7. ¿Sustantividad y aplicación judicial de un ordenamiento jurídico autonómico?. 8. Depósito de los derechos históricos. 9. Redefinición de las realidades sociales del Estado autonómico. 10. Agotamiento de las instancias procesales en el ámbito de las Comunidades Autónomas. 11. Recurso al juicio de equidad en el conflicto social autonómico. 12. Reconstitución autonómica de conceptos jurídicos indeterminados. 13. Garantías adicionales de los derechos subjetivos en las Comunidades Autónomas. 14. Incidencia del sistema de recursos jurisdiccionales en la autonomización o regionalización del Derecho del Estado. 15. Uso judicial de los idiomas autonómicos. 16. Consideraciones finales.
Aproximaciones al concepto de interés general
Authors: Zorrilla Ruiz Manuel María 
Published: February 2016

1. Morfología y difusión del poder. 2. Ordenación racional y razonable del poder. 3. Respuestas del poder a los requerimientos del interés general. 4. Descripción del espacio habitable. 5. Repercusiones de la estructura social. 6. Variedad y escenificación de los conflictos sociales. 7. Exigencias de la colaboración individual y social. 8. Incesante retorno de los apremios y valores de la solidaridad. 9. Aspectos complementarios de la colaboración. 10. Dimensión expansiva de la participación. 11. Divulgación y plenitud de los intereses generales.
Inhumanidad del terrorismo en el espacio judicial
Authors: Zorrilla Ruiz Manuel María 
Published: February 2016

1. Correlaciones de la mundialización y el terrorismo. 2. Ejercicio de competencias judiciales. 3. Decisionismo juridicopenal del legislador positivo. 4. Ambito y extensión de las acciones del Poder Judicial. 5. Actitudes sicológicas del Poder Judicial. 6. Complejidad de las acciones judiciales de represión del terrorismo. 7. Valor didáctico de la literatura judicial al respecto. 8. Coherencia de la persecución judicial del terrorismo. 9. Unidad criminal de dirección y de riesgo a efectos de responsabilidades civiles. 10. Variedad y valoración de los daños causados. 11. Control judicial de los procesos resocializadores. 12. Reacciones de la opinión pública ante el tratamiento judicial del terrorismo. 13. Politización de los procesos en pro de los intereses terroristas. 14. Objeto específico de la acción terrorista.
Modernidad y moralidad de la mundialización
Authors: Zorrilla Ruiz Manuel María 
Published: February 2016

1. Significado de la ideología de lo justo. 2. Emergencia de la mundialización. 3. Pasado edificante de la mundialización. 4. Efecto convincente de la mundialización. 5. Mundialización promotora de los valores sociales. 6. Mundialización disolvente de la Política Social. 7. Recivilización falsa del Derecho Social. 8. Racionalización moral de la vida económica.
La dimensión jurídica de la novela 'El Proceso' de Franz Kafka
Authors: Álvarez Patallo José Andrés 
Published: February 2016

Sumario: Introducción. La pesadilla de la Justicia. De la Justicia y sus servidores. Kafka ante la Ley. El laberinto de la burocracia. El hombre frente al sistema. Exculpación de los funcionarios. Vigencia de la novela. Bibliografía.