bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent mood and anxiety disorders are associated with pharmacoresistant seizures in patients with MTLE
Authors: Nogueira Mateus H. , Yasuda Clarissa L. , Coan Ana C. , Kanner Andres M. , Cendes Fernando 
Published: May 2017

SummaryObjectiveTo investigate whether mood disorders (MD) and anxiety disorders (AD) are associated with seizure control in patients with mesial temporal lobe epilepsy (MTLE). We compared patients without any current psychiatric disorder, patients with current MD and/or AD, patients with subsyndromic depression episodes (SSDE) and anxiety episodes (SSAE), and patients with family psychiatric history.MethodsIn a cross‐sectional study, we included 144 consecutive patients with MTLE (82 pharmacoresistant and 62 treatment‐responsive patients). Every patient underwent a psychiatric evaluation including the Structured Clinical Interview for DSM‐IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) Axis I (SCID‐I), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Neurological Disorders Depression Inventory for Epilepsy (NDDI‐E), and Interictal Dysphoric Disorder Inventory (IDDI). Patients were divided into four groups: PsychNeg (G1, n = 61), current SSDE and SSAE (G2, n = 26), Current MD or AD (G3, n = 25), and current mixed MD/AD (G4, n = 32).ResultsAmong patients with pharmacoresistant MTLE, 68.3% (56/82) experienced symptoms of depression and/or anxiety (G2, G3, and G4) (odds ratio [OR] 2.8, 95% confidence interval [CI] 1.41–5.53, p < 0.01). Patients with mixed MD/AD (G4, n = 24/32) were more likely to have pharmacoresistant MTLE (OR 4.04, 95% CI 1.57–10.42, p < 0.01) than psychiatric asymptomatic patients (G1, n = 26/61), and their seizure frequency was significantly higher (p < 0.01). Positive family psychiatric history was more frequent in pharmacoresistant patients (n = 27/82, OR 2.28, 95% CI 1.02–5.05, p = 0.04). Finally, 31.6% of patients with MD and or AD were not receiving psychiatric treatment.SignificanceIdentification of comorbid MD/AD and of family psychiatric history is of the essence in patients with MTLE, as they appear to be associated with worse seizure control.
Early ictal and interictal patterns in FIRES: The sparks before the blaze
Authors: Farias‐Moeller Raquel , Bartolini Luca , Staso Katelyn , Schreiber John M. , Carpenter Jessica L. 
Published: May 2017

SummaryObjectiveFebrile infection–related epilepsy syndrome (FIRES) is a catastrophic epileptic encephalopathy described as explosive onset of super refractory status epilepticus (SRSE) in previously healthy children. We describe electroencephalography (EEG) abnormalities in the hyperacute phase of FIRES, with the aim of contributing to the diagnostic characterization of a syndrome otherwise lacking specific biomarkers.MethodsThis is a retrospective single‐center, case series of seven children with FIRES. Cases were identified from a Neurocritical Care database. Patient characteristics and clinical course were obtained from electronic medical records. Electroencephalography recordings were reviewed in two segments: the initial 12 h of recording and the 12 h prior to initiation of a medically induced burst suppression (BS).ResultsFourteen 12‐h segments of video–electroencephalography (EEG) recordings were analyzed for commonalities. A beta–delta complex resembling extreme delta brush (EDB) occurred in at least one 12‐h segment for all patients. In six patients, seizures were brief and relatively infrequent during the first recording, with a gradual evolution to status epilepticus by the second. We observed a characteristic electrographic seizure pattern in six of seven patients with prolonged focal fast activity at onset. Shifting seizures were seen in four of seven patients.SignificanceThe diagnosis of FIRES is typically assigned late in a patient's clinical course, which has broad implications for clinical care and research. We retrospectively analyzed acute EEG features in seven patients with FIRES and discovered three common features: gradual increase in seizure burden, presence of a recurrent EDB, and a typical seizure pattern. Recognition of this pattern may facilitate early diagnosis and treatment.
Head, withers and pelvic movement asymmetry and their relative timing in trot in racing Thoroughbreds in training
Authors: Pfau T. , Noordwijk K. , Sepulveda Caviedes M. F. , Persson‐Sjodin E. , Barstow A. , Forbes B. , Rhodin M. 
Published: May 2017

SummaryBackgroundHorses show compensatory head movement in hindlimb lameness and compensatory pelvis movement in forelimb lameness but little is known about the relationship of withers movement symmetry with head and pelvic asymmetry in horses with naturally occurring gait asymmetries.ObjectivesTo document head, withers and pelvic movement asymmetry and timing differences in horses with naturally occurring gait asymmetries.Study designRetrospective analysis of gait data.MethodsHead, withers and pelvic movement asymmetry and timing of displacement minima and maxima were quantified from inertial sensors in 163 Thoroughbreds during trot‐ups on hard ground. Horses were divided into 4 subgroups using the direction of head and withers movement asymmetry. Scatter plots of head vs. pelvic movement asymmetry illustrated how the head–withers relationship distinguishes between contralateral and ipsilateral head–pelvic movement asymmetry. Independent t test or Mann–Whitney U test (P<0.05) compared pelvic movement asymmetry and timing differences between groups.ResultsThe relationship between head and withers asymmetry (i.e. same sided or opposite sided asymmetry) predicts the relationship between head and pelvic asymmetry in 69–77% of horses. Pelvic movement symmetry was significantly different between horses with same sign vs. opposite sign of head–withers asymmetry (P<0.0001). Timing of the maximum head height reached after contralateral (‘sound’) stance was delayed compared to withers (P = 0.02) and pelvis (P = 0.04) in horses with contralateral head–withers asymmetry.Main limitationsThe clinical lameness status of the horses was not investigated.ConclusionIn the Thoroughbreds with natural gait asymmetries investigated here, the direction of head vs. withers movement asymmetry identifies the majority of horses with ipsilateral and contralateral head and pelvic movement asymmetries. Withers movement should be further investigated for differentiating between forelimb and hindlimb lame horses. Horses with opposite sided head and withers asymmetry significantly delay the upward movement of the head after ‘sound’ forelimb stance.
Additive manufacturing and characterization of complex Al2O3 parts based on a novel stereolithography method
Authors: An Di , Li Hezhen , Xie Zhipeng , Zhu Tianbin , Luo Xudong , Shen Zhijian , Ma Jing 
Published: May 2017

AbstractIn this work, we prepared Al2O3 ceramic green parts with complex geometry and architecture using an additive manufacturing process based on stereolithography. The rheological and thermal behavior of Al2O3 slurry was firstly examined and used to establish the conditions for molding and debinding. As opposed to previous researches that only focused on manufacture techniques, the sintering behavior and densification process were systematically investigated. In addition, special attentions were paid to the evolution of microstructure between green bodies and sintered parts. The results showed that debound parts were equipped with uniform particle packing and narrow pore size distribution. The dimensions of the Al2O3 parts changed anisotropically with the different processing steps. The densification process was greatly accelerated by the decrease in pore size and annihilating of interconnected pores in which significant grain growth was observed above 1450°C. The sintered part also had a homogeneous microstructure and no interface between adjacent layers. High densification (relative density of 99.1%) and much desirable Vickers hardness (17.9 GPa) of Al2O3 parts were achieved at the sintering temperature of 1650°C.
Impact of activator chemistry on permeability of alkali‐activated slags
Authors: Blyth Anna , Eiben Catherine A. , Scherer George W. , White Claire E. 
Published: May 2017

AbstractDurability of alkali‐activated slags has been assessed by measuring the permeability using the beam‐bending technique. This nondestructive technique obtains permeability values by measuring the hydrodynamic load relaxation curve of a saturated slender beam of solid paste placed in three‐point bending. The impact of activator selection on the permeability of alkali‐activated slags has been assessed together with the effects of water‐to‐precursor ratio, revealing that free silica in the activating solution is the dominant factor controlling permeability. The permeability results have been correlated with nitrogen sorption and mercury intrusion porosimetry to elucidate the percolated pore size controlling permeability. Comparison with existing beam‐bending results for ordinary portland cement (OPC) paste shows that alkali‐activated slags can be synthesized with permeability having the same order of magnitude as for OPC, indicating that certain alkali‐activated slags are as resistant as OPC to ingress of solutions associated with deterioration processes.
Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled clinical trial
Authors: Cairo Francesco , Barbato Luigi , Tonelli Paolo , Batalocco Guido , Pagavino Gabriella , Nieri Michele 
Published: May 2017

AbstractBackgroundPeri‐implant soft tissue may be critical to prevent inflammation and promote gingival margin stability. The purpose of this randomized clinical trial (RCT) is to compare xenogeneic collagen matrix (XCM) versus connective tissue graft (CTG) to increase buccal soft tissue thickness at implant site.Materials and methodsSoft tissue augmentation with XCM (test) or CTG (control) was performed at 60 implants in 60 patients at the time of implant uncovering. Measurements were performed by a blinded examiner at baseline, 3 and 6 months. Outcome measures included buccal soft tissue thickness (GT), apico‐coronal keratinized tissue (KT), chair time and post‐operative discomfort. Visual Analogue Scale (VAS) was used to evaluate patient satisfaction.ResultsAfter 6 months, the final GT increase was 0.9 ± 0.2 in the XCM group and 1.2 ± 0.3 mm in the CTG group, with a significant difference favouring the control group (0.3 mm; p = .0001). Both procedures resulted in similar final KT amount with no significant difference between treatments. XCM was associated with significant less chair‐time (p < .0001), less post‐operative pain (p < .0001), painkillers intake (p < .0001) and higher final satisfaction than CTG (p = .0195).ConclusionCTG was more effective than XCM to increase buccal peri‐implant soft tissue thickness.
Night‐shift work is associated with poorer glycaemic control in patients with type 2 diabetes
Authors: Manodpitipong Areesa , Saetung Sunee , Nimitphong Hataikarn , Siwasaranond Nantaporn , Wongphan Thanawat , Sornsiriwong Chotima , Luckanajantachote Pranee , Mangjit Prasitchai , Keesukphan Prasit , Crowley Stephanie J. , Hood Megan M. , Reutrakul Sirimon 
Published: May 2017

SummaryThe circadian system plays a role in regulating metabolism. Night‐shift work, a form of circadian misalignment, is associated with increased type 2 diabetes risk. This study aimed to determine if night‐shift workers with type 2 diabetes experience poorer glycaemic control than non‐shift workers. Patients with type 2 diabetes (104 unemployed, 85 day workers and 60 night‐shift workers) participated. Sleep duration, sleep quality, morningness–eveningness preference, depressive symptoms and dietary intake were assessed using standardized questionnaires. Haemoglobin A1c levels were measured. Night‐shift workers had significantly higher haemoglobin A1c levels compared with others, while there were no differences between day workers and unemployed participants (median 7.86% versus 7.24% versus 7.09%, respectively). Additionally, night‐shift workers were younger, had a higher body mass index, and consumed more daily calories than others. Among night‐shift workers, there were no significant differences in haemoglobin A1c levels between those performing rotating versus non‐rotating shifts (P = 0.856), or those with clockwise versus counterclockwise shift rotation (P = 0.833). After adjusting for age, body mass index, insulin use, sleep duration, morningness–eveningness preference and percentage of daily intake from carbohydrates, night‐shift work, compared with day work, was associated with significantly higher haemoglobin A1c (B = 0.059, P = 0.044), while there were no differences between unemployed participants and day workers (B = 0.016, P = 0.572). In summary, night‐shift work is associated with poorer glycaemic control in patients with type 2 diabetes.
Europe‐wide biogeographical patterns in the diet of an ecologically and epidemiologically important mesopredator, the red fox Vulpes vulpes: a quantitative review
Authors: Soe Egle , Davison John , Süld Karmen , Valdmann Harri , Laurimaa Leidi , Saarma Urmas 
Published: May 2017

Abstract

Understanding how the diet of an ecologically important mesopredator varies throughout a large region can provide an insight into the trophic responses of generalist carnivores to global change. We review the diet of the red fox Vulpes vulpes in Europe.

The main aims of this study were: (1) to identify biogeographical patterns in red fox diet throughout Europe; (2) to investigate the significance of the human footprint index (a measure of anthropogenic influence on habitats) for the Europe‐wide food habits of red foxes; and (3) to discuss the ecosystem role of red foxes in the face of global change.

We hypothesised that in the red fox: (1) diet composition is likely to vary along a latitudinal gradient, between seasons (pooled into warm and cold periods of the year), and in relation to human impact on habitats; and (2) dietary breadth will increase with latitude and be greater during the warm period than during the cold period. We conducted a Europe‐wide analysis of red fox diet, using data from 66 studies in 17 European countries. Multivariate analysis and generalised linear models were used to evaluate variation in diet composition and niche breadth in relation to latitude, season, and human footprint index.

The analysis revealed that red fox diet composition varies considerably in response to latitude, human influence, and warm and cold periods. Dietary breadth decreases at higher latitudes in the cold period, but not in the warm period, and increases in areas with high human impact. Among individual dietary items, the consumption of lagomorphs is more frequent in areas with higher human footprint index. The occurrence of rodents and birds in fox diet increases uniformly with latitude, while that of plants and invertebrates responds differently to latitude in the warm and cold periods.

With climate warming, red foxes may incorporate a wider spectrum of food categories into their diet in northern areas in the future. Widening of fox dietary niche breadth could have important consequences for ecosystems and for the spread of zoonotic diseases.
Japanese WDR45 de novo mutation diagnosed by exome analysis: A case report
Authors: Endo Hironobu , Uenaka Takeshi , Satake Wataru , Suzuki Yutaka , Tachibana Hisatsugu , Chihara Norio , Ueda Takehiro , Sekiguchi Kenji , Mariko Taniguchi‐Ikeda , Kowa Hisatomo , Kanda Fumio , Toda Tatsushi 
Published: May 2017

AbstractA 40‐year‐old Japanese woman presented with slowly progressing parkinsonism in adulthood. She had a history of epilepsy with intellectual disability in childhood. In a head magnetic resonance scan, T2‐weighted imaging showed low signal intensity areas in the globus pallidus and the substantia nigra; T1‐weighted imaging showed a halo in the nigra. Because the patient's symptoms and history were similar to those of patients with neurodegeneration with brain iron accumulation, we ran an exome analysis to investigate neurodegeneration with brain iron accumulation‐associated genes. We identified a c.700 C>T (p.Arg 234*) mutation in exon 9 of the WDR45 gene, which had not been reported in Japanese patients with beta‐propeller protein‐associated neurodegeneration (a neurodegeneration with brain iron accumulation subtype). Sanger sequencing confirmed a heterozygous mutation in this patient that was absent in both her parents, so it was judged to be a de novo nonsense mutation.
Tree water dynamics in a drying and warming world
Authors: Grossiord Charlotte , Sevanto Sanna , Borrego Isaac , Chan Allison M. , Collins Adam D. , Dickman Lee T. , Hudson Patrick J. , McBranch Natalie , Michaletz Sean T. , Pockman William T. , Ryan Max , Vilagrosa Alberto , McDowell Nate G. 
Published: May 2017

AbstractDisentangling the relative impacts of precipitation reduction and vapour pressure deficit (VPD) on plant water dynamics and determining whether acclimation may influence these patterns in the future is an important challenge. Here, we report sap flux density (FD), stomatal conductance (Gs), hydraulic conductivity (KL) and xylem anatomy in piñon pine (Pinus edulis) and juniper (Juniperus monosperma) trees subjected to five years of precipitation reduction, atmospheric warming (elevated VPD) and their combined effects. No acclimation occurred under precipitation reduction: lower Gs and FD were found for both species compared to ambient conditions. Warming reduced the sensibility of stomata to VPD for both species but resulted in the maintenance of Gs and FD to ambient levels only for piñon. For juniper, reduced soil moisture under warming negated benefits of stomatal adjustments and resulted in reduced FD, Gs and KL. Although reduced stomatal sensitivity to VPD also occurred under combined stresses, reductions in Gs, FD and KL took place to similar levels as under single stresses for both species. Our results show that stomatal conductance adjustments to high VPD could minimize but not entirely prevent additive effects of warming and drying on water use and carbon acquisition of trees in semi‐arid regions.
Positive role of phytochromes in Nicotiana tabacum against Cucumber mosaic virus via a salicylic acid‐dependent pathway
Authors: Chen L.‐J. , Fei C.‐Y. , Xu Z.‐P. , Wu G. , Lin H.‐H. , Xi D.‐H. 
Published: May 2017

Previous literature indicates that both light and photoreceptors may play key roles in host susceptibility to viruses. Studies have already suggested that phytochrome B is essential for the defence strategies of Nicotiana tabacum against Cucumber mosaic virus (CMV). Here, further investigations are made into the roles of phytochromes in N. tabacum against CMV. The recombinant vector pRNAi‐LIC‐PHYA/PHYB was used to produce tobacco phyA, phyB and phyAphyB mutants via the Agrobacterium‐mediated transformation method. The results suggest that both phyA and phyB deficiency increase the susceptibility of N. tabacum to CMV infection. Mutant plants showed more obvious CMV‐induced symptoms and higher transcriptional levels of the CMV coat protein gene than wild type plants, and the effect was clearly synergistic in the phyAphyB double mutant. Furthermore, the data show that mutations in phyA/phyB up‐regulate the sensitivity of N. tabacum to CMV by repressing the salicylic acid (SA)‐mediated defence pathway in tobacco plants. Additionally, the results indicate that phytochrome signalling strongly modulates the response of N. tabacum to endogenous SA but not to endogenous jasmonic acid. Taken together, these results reinforce the idea that intact phytochrome signalling plays a positive role in the ability of N. tabacum to resist CMV and is required for the induction and development of SA‐mediated defence responses in CMV‐inoculated N. tabacum.
Blood donors' attitudes towards voluntary non‐remunerated donation in Trinidad and Tobago
Authors: Charles K. S. , Poon King A. , Ramai A. , Rajnath K. , Ramkissoon D. , Ramkissoon S. , Ramlal C. , Ramnarine K. , Rampersad K. , Legall G. , Pooransingh S. , Chantry A. D. 
Published: May 2017

SUMMARYObjectivesTo assess the attitude towards voluntary non‐remunerated blood donation among blood donors in Trinidad and Tobago (TRT).BackgroundBlood donors in TRT are either family replacement (F/R, 87%) or remunerated (13%). There is chronic blood shortage and high seroreactivity for transfusion‐transmissible infections (TTI) in donors. Converting existing to voluntary non‐remunerated donors (VNRD) reduces the need to recruit news donors in achieving 100% VNRD.MethodsA questionnaire‐based, cross‐sectional survey was conducted at two blood collection centres at an interval of 8 years. Donors were surveyed for sociodemographic characteristics, awareness of the blood shortage, previous donation behaviour, donor‐beneficiary linkage if F/R, willingness to become VNRD and choice of motivators for converting to VNRD.ResultsA total of 400 and 595 donors respectively participated in Surveys 1 and 2, of whom 92·8 and 86·3% were F/R (P < 0·001), respectively. In both surveys, 52% of participants were unaware of an existing blood shortage (P = 0·983). Only 9·8 and 9·1% of participants expressed unwillingness to become VNRD (P = 0·720). The main motivators to convert to VNRD were reminders from the centre (84%) and extended opening hours (78%) in Survey 1 as compared to confidence that donated blood was used properly (73%) and shortened waiting times to donate (73%) in Survey 2.ConclusionDespite low awareness of blood shortage, willingness to become VNRD was high among existing donors. Accountability and donor convenience underpinned the main motivators for converting to VNRD.
Pulmonary pythiosis in a canine patient
Authors: Kepler Darin , Cole Robert , Lee‐Fowler Tekla , Koehler Jey , Shrader Stephanie , Newton Joe 
Published: May 2017

AbstractA Staffordshire terrier presented for evaluation of a chronic, nonproductive cough that was unresponsive to antibiotic therapy. A large mass identified in the pulmonary hilum was most consistent with tracheobronchial lymphadenopathy on radiographic and computed tomography (CT) images. Bronchoscopy confirmed a mass compressing the dorsal portion of the intrathoracic trachea. Bronchoscopic biopsies of the tracheal mass revealed necrosuppurative and eosinophilic inflammation with intralesional Pythium insidiousum hyphae. Pythiosis should be included as a differential diagnosis for tracheobronchial lymphadenopathy and bronchopneumopathy in dogs, especially when the patient is from or has visited a region endemic for Pythium insidiosum.
Modelling of water reserves in mineral soils with different retention properties
Authors: Orzepowski Wojciech , Paruch Adam M. , Kowalczyk Tomasz , Pokładek Ryszard , Pulikowski Krzysztof 
Published: May 2017

AbstractThis work focuses on modelling soil water reserves using an Artificial Neural Network (ANN). Four model variants were established based on 843 records (verified through 268 measurements) of soil water content (SWC) measured at full‐scale field sites located in Southwest Poland. It is revealed that commonly recorded climatic data (precipitation and temperature) linked with SWC and field water capacity (FWC) are applicable in the ANN modelling. The basic model (utilising the meteorological data) was the most suitable for soil profiles with thicknesses of 0–25 cm, while in profiles with thicknesses of 0–50 cm and 0–100 cm the comprehensive ANN model (linking climatic data, FWC and SWC) was the most appropriate. Furthermore, comparative studies of the measured and modelled data indicated their statistical convergence, thus providing support for the practical implementation of the proposed ANN modelling.
Complete Genome Sequence of Staphylococcus aureus Bacteriophage pSa-3
Authors: Kim Sang Guen , Jun Jin Woo , Giri Sib Sankar , Yun Saekil , Kim Hyoun Joong , Chi Cheng , Kim Sang Wha , Park Se Chang 
Published: May 2017

ABSTRACT

Staphylococcus aureus
phage pSa-3, isolated in South Korea from a sewage sample, has a 137-kb genome with 29% G+C content. This phage was targeted to control the bacteria in clinical isolates (mainly from skin lesions) and can be used in the decolonization of
S. aureus
.