bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Evaluation of Angiotensin-Converting Enzyme Inhibitors in Renal Elimination with Selected Molecular Descriptors
Authors: Trbojevic Jovana , Odovic Jadranka , Trbojevic-Stankovic Jasna , Stojimirovic Biljana , Jelic Ratomir 
Published: June 2017

Abstract
Angiotensin-converting enzyme (ACE) inhibitors modulate the function of the renin-angiotensin-aldosterone system, and they are commonly prescribed antihypertensive drugs especially in patients with renal failure. In this study, the relationships between several molecular properties of eight ACE inhibitors (enalapril, quinapril, fosinopril, ramipril, benazepril, perindopril, moexipril, trandolapril) and their renal elimination data, from relevant literature, were investigated. The ’molecular descriptors of the ACE inhibitors, which included aqueous solubility data (logS); an electronic descriptor, polar surface area (PSA);, a constitutional parameter, molecular mass (Mr); and a geometric descriptor, volume value (Vol), as well as lipophilicity descriptors (logP values), were calculated using different software packages. Simple linear regression analysis showed the best correlation between renal elimination data and lipophilicity descriptor AClogP values (R2 = 0.5742). In the next stage of the study, multiple linear regression was applied to assess a higher correlation between the ACE inhibitors’ renal elimination data and lipophilicity, AClogP, with one additional descriptor as an independent variable. Good correlations were established between renal elimination data from the literature and the AClogP lipophilicity descriptor using the constitutional parameter (molecular mass (R2 = 0.7425)) or the geometric descriptor (volume value (R2 = 0.7224)) as an independent variable. The application of computed molecular descriptors in evaluating drug elimination is of great importance in drug research.
Brückners Höflichkeitskonzept (1916): Linguistik oder Ideologie?
Authors: Warditz Vladislava 
Published: June 2017

Summary
The paper presents the Polish study Ty-wy-pan. Kartka z dziejów próżności ludzkiej (‘You (singular)–you (plural)–Lord. An overview on the history of the people’s vanity’, 1916) by Alexander Brückner from a linguistic-pragmatical as well as ideological point of view. In his pioneer study on politeness, the German-Polish slavist Brückner (1856–1939) critically reflects on the current system of Polish addresses and titles, especially in relating to the soon-to-be refoundation of the Second Polish Republic (1918). The paper analyzes how his linguistic description and his ideas for reformation of the Polish addressative system are pragmatically justified and how they are ideologically motivated. Furthermore, the paper reconstructs the status of Brückner’s concept of politeness in the context of current studies on Polish pragmatics.
Characterization of electrochemical flow cell configurations with implemented disposable electrodes for the direct coupling to mass spectrometry
Authors: Herl Thomas , Matysik Frank-Michael 
Published: June 2017

Abstract
The characterization of the redox behavior of analytes is a very important aspect for many applications. Pure
electrochemical approaches can provide useful information on electroactive species, but are of limited use regarding the
identification of generated species. The hyphenation of electrochemistry and mass spectrometry (EC-MS) is a powerful
method to investigate redox systems. In the present work, we show a simple approach to on-line EC-MS based on the
application of electrochemical flow cells with implemented disposable electrodes. They are connected to electrospray
ionization mass spectrometry (ESI-MS) via fused silica capillary tubing. The modularity of the flow cells offers a high
flexibility of experimental setup and settings, so that a fast detection of oxidation or reduction products can be
achieved. The usage of disposable electrodes guarantees a high level of quality assurance for EC-MS measurements.
Toward understanding non-coding RNA roles in intracranial aneurysms and subarachnoid hemorrhage
Authors: Huang Fengzhen , Yi Jiping , Zhou Tieqiao , Gong Xiaoxiang , Jiang Hong , Yao Xiaoxi 
Published: June 2017

AbstractSubarachnoid hemorrhage (SAH) is a common and frequently life-threatening cerebrovascular disease, which is mostly related with a ruptured intracranial aneurysm. Its complications include rebleeding, early brain injury, cerebral vasospasm, delayed cerebral ischemia, chronic hydrocephalus, and also non neurological problems. Non-coding RNAs (ncRNAs), comprising of microRNAs (miRNAs), small interfering RNAs (siRNAs) and long non-coding RNAs (lncRNAs), play an important role in intracranial aneurysms and SAH. Here, we review the non-coding RNAs expression profile and their related mechanisms in intracranial aneurysms and SAH. Moreover, we suggest that these non-coding RNAs function as novel molecular biomarkers to predict intracranial aneurysms and SAH, and may yield new therapies after SAH in the future.
Ruling-in and Ruling-out Significant Fibrosis and Cirrhosis in Patients with Chronic Hepatitis C Using a Shear Wave Measurement Method
Authors: Ferraioli Giovanna , Maiocchi Laura , Lissandrin Raffaella , Tinelli Carmine , De Silvestri Annalisa , Filice Carlo 
Published: May 2017

Aims: To prospectively assess the cutoff values of a point shear wave measurement (SWM) method for ruling-in and ruling-out significant fibrosis and cirrhosis using transient elastography (TE) as the reference standard.Method: Consecutive patients with chronic hepatitis C were enrolled. Liver stiffness was assessed with the SWM method implemented on the HI VISION Ascendus ultrasound system (Hitachi Ltd, Japan) and with the TE method of the FibroScan® device (Echosens, France). For staging significant fibrosis (F≥2) and cirrhosis (F=4) we used the TE cutoffs of 7.0 and 12.0 kiloPascal (kPa), respectively. The diagnostic performance of SWM was assessed by calculating the area under the receiver operating characteristic (AUROC) curve. Cutoffs with specificity or sensitivity > 90% were chosen to rule-in or rule-out F≥2 and F=4.Results: 445 individuals [235 males, 210 females; mean age, 61.1 (13.3) years] were studied: 190 (42.7%) individuals had F0-F1 fibrosis stage, 82 (18.4%) F2, 46 (10.3%) F3, and 127 (28.6%) F4 fibrosis stage. For ruling-in F≥2 the SWM cutoff was 6.78 kPa [sensitivity, 76.9%(70.6-82.4); specificity, 90.3% (85.0-94.3)] and for ruling-out it was 5.55 kPa [sensitivity, 90.6% (85.8-94.1); specificity, 72.2% (64.9-78.6)]. For ruling-in F=4 the SWM cutoff was 9.15 kPa [sensitivity, 83.3% (74.4-90.2); specificity, 90.1% (86.0-93.2)] and for ruling-out it was 8.41 kPa [sensitivity, 90.6% (82.9-95.6); specificity, 82.2% (77.3-86.4)]. AUROCs were 0.92 (0.89-0.94) for F≥2 and 0.94 (0.91-0.96) for F=4.Conclusions. In clinical practice, the use of a dual cutoff of SWM may increase the confidence in staging liver fibrosis with a non-invasive shear wave elastography technique.Abbreviations: ARFI: acoustic radiation force impulse; AUROC: area under the ROC curve; CCC: concordance correlation coefficient; IQR/M: interquartile range/median; LSM: liver stiffness measurement; ROC: receiver operating characteristic; pSWE: point shear wave elastography; SWM: shear wave measurement; TE: transient elastography; US: ultrasound.
Major Hereditary Gastrointestinal Cancer Syndromes: a Narrative Review
Authors: Chintalacheruvu Lakshmi Manogna , Shaw Trudy , Buddam Avanija , Diab Osama , Kassim Thamer , Mukherjee Sandeep , Lynch Henry T. 
Published: May 2017

Gastrointestinal cancer is one of the major causes of death worldwide. Hereditary gastrointestinal cancer syndromes constitute about 5-10% of all cancers. About 20-25% of undiagnosed cases have a possible hereditary component, which is not yet established. In the last few decades, the advance in genomics has led to the discovery of multiple cancer predisposition genes in gastrointestinal cancer. Physicians should be aware of these syndromes to identify high-risk patients and offer genetic testing to prevent cancer death. In this review, we describe clinical manifestations, genetic testing and its challenges, diagnosis and management of the major hereditary gastrointestinal cancer syndromes.Key words: − − − − .Abbreviations: ACG: American College of Gastroenterology; AFAP: attenuated FAP; APC: adenomatous polyposis coli; CDH1: E-cadherin; CHRPE: congenital hypertrophy of the retinal pigment epithelium; CRC: colorectal cancer; FAMMM: Familial atypical multiple mole melanoma; FAP: Familial adenomatous polyposis; GC: gastric cancer; HDGC: Hereditary diffuse gastric cancer; IHC: immunohistochemical; IPAA: ileal pouch–anal anastomosis; IRA: ileorectal anastomosis; MSI: microsatellite instability; MMR: mismatch repair; miRNA: micro RNA.
Legitimation theological of suffering as pedagogy: critical in Veena Das
Authors: Coelho Allan Da Silva 
Published: May 2017

understand the relationship that the Indian anthropologist Veena Das articulates between pedagogy and theodicies in social legitimacy of human suffering. How the theological legitimacy of suffering constitute pedagogic fundamentals of practices that educate the body and administer the sense of living in the framework of the capitalist ethos? For Das, a theodicy, as necessary suffering, displaced from the religious to the secular uses pain and suffering as a basis for Pedagogy. In Modernity, pain and suffering are played in the symbolic universe, the configuration and adherence to modern apitalist ethos, indicating the “way of being” normal as acceptance of a moral sense to the suffering and subordination in the face of laws and institutions. It is pedagogy for subalternizar, but not always resign. Sometimes in dispute of meanings, prepares a form of resistance facing the absurdity non-sense of pain.
ACADEMIC INTEGRITY SUPPORT SYSTEM FOR UKRAINIAN UNIVERSITIES
Authors: Sherstjuk V. G. , Zharikova M. V. 
Published: May 2017

Purpose. Developing the methodology for providing academic integrity in the university. The methodology is based on Web-oriented academic integrity support system, developed by the authors, which enters into the information system of learning process control. Academic integrity support system is aimed at maintaining academic integrity as a basic institutional value, which will help to reduce corruption, plagiarism and other types of academic dishonesty. Methodology. The methodology of problem to solve is based on the development of the information system of education process control with the integral elements of quality control. The information subsystem of academic integrity support is its basic part. Findings. The proposed information system allows us to fulfill the following levels: educational process monitoring; audit of internal processes, which is necessary for developing the effective quality control system; assessment of achievements of educational process participants; formalization of the interaction of educational process participants. The system is aimed at the development of new academic society based on the following principles: open access to the information, at which the access of wide audience to the information provides participation, forming the sense of responsibility and social control; transparency of the information, by which its relevance, quality, reliability are meant; responsibility of all members of educational process; measurability, at which any action in educational process should be measured; detail of describing the actions, results and processes; support, which is meant by automatic tools of the realization of the principles of open access to the information, transparency of the information, responsibility of all participants of educational process, measurability, detail, support. The practical realization of information system is based on the development of a common repository of university information. The repository should be organized as a hypercube having abundance of dimensions, for example by students, teachers, courses, rooms, educational programs and plans. Originality. The new four-level concept of the information system of academic integrity support is first proposed. Practical value. The proposed system allows increasing dishonesty in academic society and gives rise to the integration of Ukrainian universities into the Europe. The proposed ideas will be represented in the pilot project of information system of learning process control in Kherson National Technical University.
Social Network Structures of Breast Cancer Patients and the Contributing Role of Patient Navigators
Authors: Gunn Christine M. , Parker Victoria A. , Bak Sharon M. , Ko Naomi , Nelson Kerrie P. , Battaglia Tracy A. 
Published: May 2017

Abstract

Background
Minority women in the U.S. continue to experience inferior breast cancer outcomes compared with white women, in part due to delays in care delivery. Emerging cancer care delivery models like patient navigation focus on social barriers, but evidence demonstrating how these models increase social capital is lacking. This pilot study describes the social networks of newly diagnosed breast cancer patients and explores the contributing role of patient navigators.

Materials and Methods
Twenty-five women completed a one hour interview about their social networks related to cancer care support. Network metrics identified important structural attributes and influential individuals. Bivariate associations between network metrics, type of network, and whether the network included a navigator were measured. Secondary analyses explored associations between network structures and clinical outcomes.

Results
We identified three types of networks: kin-based, role and/or affect-based, or heterogeneous. Network metrics did not vary significantly by network type. There was a low prevalence of navigators included in the support networks (25%). Network density scores were significantly higher in those networks without a navigator. Network metrics were not predictive of clinical outcomes in multivariate models.

Conclusion
Patient navigators were not frequently included in support networks, but provided distinctive types of support. If navigators can identify patients with poorly integrated (less dense) social networks, or who have unmet tangible support needs, the intensity of navigation services could be tailored. Services and systems that address gaps and variations in patient social networks should be explored for their potential to reduce cancer health disparities.
Estudio exploratorio sobre las inferencias generadas por el texto de poesía religiosa, en los jóvenes universitarios de la carrera de comunicación social de la universidad politécnica salesiana de Guayaquil.
Authors: Merchan arias Hugo Alain 
Published: June 2017

<p>El presente trabajo es una investigación exploratoria cualitativa sobre las inferencias que se generan a partir de la lectura de poesía religiosa, con la intensión de para rescatar y valorizar este género literario en la ciudad portuaria de Guayaquil. Planteándonos conocer que inferencia son producido luego de leer poesía religiosa guayaquileña, Se pudo determinar por medio del análisis de contenido, que los jóvenes coinciden con el valor trasmitidos por los poetas en comparación a la música de reggaetón, que no genera ningún tipo de inferencias en los participantes universitarios, las inferencias generadas por la poesía religiosa están relacionadas con la Vinculación de respeto ecológico; El sentido de amar en nuestras interrelaciones; Capacidad creativa para superar las adversidades de la vida con ayuda de los pares; como el equilibrio integrar del dolor y el amor para sobreponerse a las pruebas de la vida; y conexión cognitiva con lo divino.</p>
Los Museos ¿Espacios para incentivar conocimientos y disertaciones sobre el pasado?
Authors: Uribe Taborda Saúl Fernando 
Published: June 2017

<p>El presente artículo reflexiona el rol del Museo como institución que salvaguarda y conserva los vestigios del pasado, cuya función se configura como espacio estructurador, condicionante y eje institucional de las miradas hacia la memoria social y colectiva de los pueblos latinoamericanos. En este trabajo argumento cómo el museo constituye un espacio que contribuye a la reproducción y legitimación de ideas e ideologías enraizadas en el proyecto de modernidad/colonialidad, y de qué forma se establecen visiones del pasado que excluyen las historias y experiencias de los “otros”. </p>
Impacto del sistema de alertas "semaforo" del contenido de azúcar, sal y grasa en etiquetas de alimentos procesados: enfoque cualitativo
Authors: Poveda Antonio 
Published: June 2017

<pre id="tw-target-text" class="tw-data-text tw-ta tw-text-small" style="text-align: left; height: 960px;" dir="ltr" data-placeholder="Translation" data-fulltext=""><span lang="es">El Ministerio de Salud Pública de Ecuador (LATAM), por decreto ministerial implementado en noviembre de 2013 una medida innovadora en un esfuerzo por mejorar los hábitos alimenticios de la población ecuatoriana y así reducir la incidencia de enfermedades causadas por una nutrición deficiente. Los productores de alimentos procesados se vieron obligados a poner en sus etiquetas de producto un sistema gráfico que indica a los consumidores la cantidad de grasa, azúcar y sal en sus productos mediante el uso de colores rojo, amarillo y verde como advertencia. Esta investigación busca analizar el impacto de la implementación de este sistema de alerta en el consumo de alimentos procesados para considerar si la medida realmente ha tenido el impacto deseado y ha reducido el consumo de productos con altos niveles de azúcar, sal y grasa. A través de entrevistas en profundidad con los jefes de familia de clase media y alta de la ciudad de Guayaquil, se encontró que en general los ciudadanos están de acuerdo con la medida y consideran negativamente los productos con alerta roja (alto contenido de azúcar, sal y grasa). Incluso pensando que han reducido la cantidad de consumo de este tipo de productos, son pesimistas acerca de la posibilidad de dejar de comprarlos.</span></pre>
ELETROESTIMULAÇÃO DO NERVO TIBIAL POSTERIOR EM MULHERES COM BEXIGA HIPERATIVA: REVISÃO SISTEMÁTICA
Authors: Monteiro Alana Karina Santos , Pinho Liziane Estrela , Gomes Asley Pimenta , Aragão dos Santos Adriana Saraiva 
Published: May 2017

Introdução: A Síndrome da Bexiga Hiperativa (BH) consiste na segunda causa mais comum da incontinência urinária e apresenta um impacto psicológico considerável nas mulheres, principalmente com idade avançada. Sua desordem afeta o sistema parassimpático podendo interferir no esvaziamento vesical. A fisioterapia apresenta diversas intervenções conservadoras que ajudam na melhora do quadro do paciente, como a eletroestimulação do nervo tibial posterior (EENTP), essa técnica tem se mostrado menos invasiva, mais aceita e sem efeitos adversos quando comparada a outros métodos de tratamento para a BH. Este estudo tem como objetivo reunir evidências cientifica a fim de identificar os possíveis efeitos da EENTP em mulheres com BH. Metériais e Métodos: Revisão sistemática de literatura incluindo ensaios clínicos controlados randomizados encontrados nas bases de dados, LILACS, PubMed, PEDro, Cochrane e Bireme. Resultados: Foram encontrados 421, dos quais cinco corresponderam aos critérios de inclusão. As variáveis de interesse dos estudos foram: a presença dos sintomas de frequência urinária, urgência miccional, noctúria associada à incontinência urinária em mulheres antes e após o tratamento. Conclusão: Esse artigo mostrou que a EENTP é uma ferramenta conservadora da fisioterapia, menos invasiva que outras terapias, sendo bem tolerada pelos pacientes e tem demostrando eficaz no tratamento da bexiga hiperativa.
Outcome of ultrasound guided closed drainage of acute suppurative thyroid abscess as a definitive treatment modality
Authors: S. Ravi K. , Bhat Vinay S. 
Published: May 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Thyroid abscess are relatively uncommon conditions in otolaryngology-head and neck surgery because of thyroid glands anatomical and physiological protective barrier. When it occurs it results in significant morbidity with potential mortality. Traditionally, surgical incision and drainage with antibiotics has been the mainstay of treatment. Some reports have suggested that ultrasound guided closed drainage is a less invasive and effective alternative in selected cases. The aim of our study is to evaluate the efficacy of ultrasound guided percutaneous closed drainage in the management of thyroid abscess. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">From January 2013 to December 2016, patients presenting with thyroid abscess to the department of otolaryngology at Adichunchanagiri hospital and who subsequently underwent ultrasound guided percutaneous closed drainage were included in the study. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Five patients were recruited for the study. After the aspiration of pus under ultrasound guidance, all patients were symptomatically improved and no patients needed open surgical drainage afterwards. After treatment, all patients were cured of their disease completely without any complications and with reduced hospital stay. After discharge, no patient showed any signs of relapse on regular follow-up. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Ultrasound guided percutaneous closed drainage of thyroid abscess is an effective and safe procedure because of good clinical outcome, patient satisfaction and reduced hospital stay. It is an effective alternative to open incision and drainage of thyroid abscess.</span></p>
HAEMAGLUTINATION OF Shigella flexneri SUBUNIT PILI PROTEIN 18 KDA AS A MOLECULE ADHESION IN MICE ENTEROCYTES
Authors: Fitrianingsih Avin Ainur 
Published: May 2017

<p><em>Diarrhoeal diseases are still a major cause of the high morbidity and mortality of children globally, especially in children under five years.</em><em> </em><em>Diarrhea caused by </em><em>S</em><em>higella flexneri usual dealt with antibiotics seen it is getting resistant with various antibiotic</em><em>. </em><em> Prevention shigellosis with a vaccine that was developed and used now are still limited</em><em>. T</em><em>his study attempts to explore hemaglutinin protein pili </em><em>S</em><em> . </em><em>f</em><em>lexneri allegedly role in adhesion bacteria on the mice enterocyte.</em><em> </em><em>This research</em><em> using </em><em> hemaglutina</em><em>tion</em><em> </em><em>test </em><em>then adhesion</em><em> test </em><em> by means of </em><em>reacting </em><em>protein </em><em>sub unit </em><em>pili </em><em>18 kDa S. flexneri </em><em>with </em><em>mice </em><em>entero</em><em>cyte cells</em><em> and observed the amount of bacteria inherent in a </em><em>mice </em><em>cell entero</em><em>cyte</em><em>. The research found that</em><em> </em><em>proteins sub unit pili with molecules</em><em> weight</em><em> 18 k</em><em>D</em><em>a is a protein </em><em>that </em><em>capable </em><em>to agglutinate mice </em><em>red blood cells </em><em>with highest</em><em> dilution and capable </em><em>to</em><em> inhibit </em><em>adhesion</em><em> bacteria on the </em><em>mice </em><em>entero</em><em>cyte</em><em> significantly</em><em>.</em></p><p><strong><em> </em></strong></p><p><strong>Keywords</strong>:<em> Shigella flexneri, </em><em>protein </em><em>sub</em><em> </em><em>unit </em><em>pili </em><em>, hemagglutinin protein, adhesin</em><em> protein</em><em>.</em></p>