bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shortened Nonword Repetition Task (NWR-S): A Simple, Quick, and Less Expensive Outcome to Identify Children With Combined Specific Language and Reading Impairment
Authors: le Clercq Carlijn M. P. , van der Schroeff Marc P. , Rispens Judith E. , Ruytjens Liesbet , Goedegebure André , van Ingen Gijs , Franken Marie-Christine 
Published: July 2017

Purpose
The purpose of this research note was to validate a simplified version of the Dutch nonword repetition task (NWR; Rispens & Baker, 2012). The NWR was shortened and scoring was transformed to correct/incorrect nonwords, resulting in the shortened NWR (NWR-S).

Method

NWR-S and NWR performance were compared in the previously published data set of Rispens and Baker (2012;
N
= 88), who compared NWR performance in 5 participant groups: specific language impairment (SLI), reading impairment (RI), both SLI and RI, one control group matched on chronological age, and one control group matched on language age.

Results
Analyses of variance showed that children with SLI + RI performed significantly worse than other participant groups in NWR-S, just as in NWR. Logistic regression analyses showed that both tasks can predict an SLI + RI outcome. NWR-S holds a sensitivity of 82.6% and a specificity of 95.4% in identifying children with SLI + RI. The sensitivity of the original NWR is 87.0% with a specificity of 87.7%.

Conclusions
As the original NWR, the NWR-S comprising a subset of 22 nonwords scored with a simplified scoring system can identify children with combined SLI and RI while saving a significant amount of the needed assessment time.

Supplemental Materials

https://doi.org/10.23641/asha.5150116
The disappearance and reformation of the accretion disc during a low state of FO Aquarii
Authors: Hameury J.-M. , Lasota J.-P. 
Published: July 2017

Context. FO Aquarii, an asynchronous magnetic cataclysmic variable (intermediate polar) went into a low state in 2016, from which it slowly and steadily recovered without showing dwarf nova outbursts. This requires explanation since in a low state, the mass-transfer rate is in principle too low for the disc to be fully ionised and the disc should be subject to the standard thermal and viscous instability observed in dwarf novae.
Aims. We investigate the conditions under which an accretion disc in an intermediate polar could exhibit a luminosity drop of two magnitudes in the optical band without showing outbursts.
Methods. We use our numerical code for the time evolution of accretion discs, including other light sources from the system (primary, secondary, hot spot).
Results. We show that although it is marginally possible for the accretion disc in the low state to stay on the hot stable branch, the required mass-transfer rate in the normal state would then have to be extremely high, of the order of 1019 g s-1 or even larger. This would make the system so intrinsically bright that its distance should be much larger than allowed by all estimates. We show that observations of FO Aqr are well accounted for by the same mechanism that we have suggested as explaining the absence of outbursts during low states of VY Scl stars: during the decay, the magnetospheric radius exceeds the circularisation radius, so that the disc disappears before it enters the instability strip for dwarf nova outbursts.
Conclusions. Our results are unaffected, and even reinforced, if accretion proceeds both via the accretion disc and directly via the stream during some intermediate stages; the detailed process through which the disc disappears still requires investigation.
Decreased Expression of Integrin Subunits α3, α6, and α8 in the Branching Airway Mesenchyme of Nitrofen-Induced Hypoplastic Lungs
Authors: Takahashi Toshiaki , Friedmacher Florian , Zimmer Julia , Puri Prem 
Published: July 2017

Introduction Pulmonary hypoplasia (PH), characterized by smaller lung size and reduced airway branching, remains a major cause of neonatal mortality in newborns with congenital diaphragmatic hernia (CDH). Integrin-mediated cell–matrix interactions play an essential role in the fetal lung mesenchyme by stimulating branching morphogenesis. Mice lacking integrin subunits α3 (Itga3) and α6 (Itga6) exhibit severe PH. Furthermore, Itga8-knockout mice show defective airway branching, suggesting that Itga3, Itga6, and Itga8 are crucial for fetal lung development. We hypothesized that expression of Itga3, Itga6, and Itga8 is decreased in the branching airway mesenchyme of hypoplastic rat lungs in the nitrofen-induced CDH model.
Materials and Methods Time-mated rats received nitrofen or vehicle on gestational day 9 (D9). Fetuses were sacrificed on D15, D18, and D21, and dissected lungs were divided into control and nitrofen-exposed specimens (n = 12 per time-point and group, respectively). Pulmonary gene expression of Itga3, Itga6, and Itga8 was analyzed by quantitative real-time polymerase chain reaction. Immunofluorescence double-staining for Itga3, Itga6, and Itga8 was combined with the mesenchymal marker Fgf10 to evaluate protein expression and localization in branching airway tissue.
Results Relative mRNA expression of Itga3, Itga6, and Itga8 was significantly decreased in lungs of nitrofen-exposed fetuses on D15, D18, and D21 compared with controls. Confocal laser scanning microscopy showed markedly diminished immunofluorescence of Itga3, Itga6, and Itga8 mainly in mesenchymal cells surrounding branching airways of nitrofen-exposed fetuses on D15, D18, and D21 compared with controls.
Conclusion Decreased expression of Itga3, Itga6, and Itga8 in the pulmonary mesenchyme may lead to disruptions in airway branching morphogenesis, thus contributing to PH in the nitrofen-induced CDH model.
Management of Axillary Web Syndrome after Breast Cancer: Evidence-Based Practice
Authors: Luz Clarissa Medeiros da , Deitos Julia , Siqueira Thais Cristina , Palú Marina , Heck Ailime Perito Feiber 
Published: July 2017

AbstractAxillary web syndrome is characterized as a physical-functional complication that impacts the quality of life of women who have undergone treatment for breast cancer. The present study aims to verify the physiotherapy treatment available for axillary web syndrome after surgery for breast cancer in the context of evidence-based practice. The selection criteria included papers discussing treatment protocols used for axillary web syndrome after treatment for breast cancer. The search was performed in the MEDLINE, Scopus, PEDro and LILACS databases using the terms axillary web syndrome, lymphadenectomy and breast cancer, focusing on women with a previous diagnosis of breast cancer who underwent surgery with lymphadenectomy as part of their treatment. From the 262 studies found, 4 articles that used physiotherapy treatment were selected. The physiotherapy treatment was based on lymphatic drainage, tissue mobilization, stretching and strengthening. The four selected articles had the same outcome: improvement in arm pain and shoulder function and/or dissipation of the axillary cord. Although axillary web syndrome seems to be as frequent and detrimental as other morbidities after cancer treatment, there are few studies on this subject. The publications are even scarcer when considering studies with an interventional approach. Randomized controlled trials are necessary to support the rehabilitation resources for axillary web syndrome.
Induction of Labor using Misoprostol in a Tertiary Hospital in the Southeast of Brazil
Authors: Silva Tácito Augusto Godoy , Borges Júnior Luciano Eliziário , Tahan Luisa Almeida , Costa Taynná Ferreira Arantes , Magalhães Fernanda Oliveira , Peixoto Alberto Borges , Martins Wellington de Paula , Araujo Júnior Edward 
Published: July 2017

Purpose To assess cases of labor induction with vaginal 25-µg tablets of misoprostol and maternal outcomes in a tertiary hospital in southeastern Brazil.
Methods This was a retrospective cohort study of 412 pregnant women with indication for labor induction. Labor induction was performed with vaginal 25-µg tablets of misoprostol in pregnant women with Bishop scores < 6. Stepwise regression analysis was used to identify the factors present at the beginning of induction that could be used as predictors of successful labor induction.
Results A total of 69% of the pregnant women who underwent labor induction progressed to vaginal delivery, and 31% of the women progressed to cesarean section. One or two misoprostol tablets were used in 244 patients (59.2%). Of the 412 patients, 197 (47.8%) required oxytocin later on in the labor process, after induction with misoprostol. The stepwise regression analysis showed that only Bishop scores of 4 and 5 and previous vaginal delivery were independent factors with statistical significance in the prediction of successful vaginal labor induction (β = 0.23, p < 0.001, for a Bishop score of 4 and 5, and β = 0.22, p < 0.001, for previous vaginal delivery).
Conclusion Higher Bishop scores and previous vaginal delivery were the best predictors of successful labor induction with vaginal 25-µg tablets of misoprostol.
Diagnostik der periprothetischen Gelenkinfektion bei Schulterendoprothesen
Authors: Fink Bernd , Sevelda Florian 
Published: July 2017

ZusammenfassungPeriprothetische Gelenkinfektionen sind eine der häufigsten Ursachen für Schmerzen und Revisionsoperationen bei Schulterendprothesen. Propionibacterium acnes ist einer der am häufigsten nachgewiesenen Keime und ist aufgrund des sehr langsamen Wachstums schwer zu identifizieren. Die verschiedenen Verfahren zur Verifizierung einer periprothetischen Schulterinfektion werden in dieser Arbeit dargestellt. Hierbei ist eine Kombination von unspezifischen und spezifischen (Keimisolation mit Antibiogramm) Testverfahren hilfreich, um eine periprothetische Infektion bestmöglich zu diagnostizieren. Ein Punktat des Gelenks erlaubt, verschiedene unspezifische und spezifische Testverfahren zu kombinieren. Bei einer Punctio sicca und Infektverdacht empfehlen wir die Biopsie des Gelenks.
High Level of Progesteron Receptor Membrane Component 1 (PGRMC 1) in Tissue of Breast Cancer Patients is Associated with Worse Response to Anthracycline-Based Neoadjuvant Therapy
Authors: Willibald Marina , Wurster Isabel , Meisner Christoph , Vogel Ulrich , Seeger Harald , Mueck Alfred , Fehm Tanja , Neubauer Hans 
Published: July 2017

AbstractPGRMC1 is known to be highly expressed in breast cancer tissue and is associated with chemoresistance in breast cancer cells. However, its role in breast cancer signaling is not fully understood yet. In the present study, the expression status of PGRMC1 and its phosphorylated version (pPGRMC1) in breast cancer tissue and surrounding stroma before and after neoadjuvant therapy was examined to find a possible association to therapy response. Tissue biopsies of 69 breast cancer patients were analyzed by immunohistochemistry for expression levels of PGRMC1 and pPGRMC1. Expression status of PGRMC1 and pPGRMC1 in tumor tissue was compared with expression status of progesterone receptor (PR), estrogen receptor α (ERα), total estrogen receptor β (ERβ), ERβ1, ERβ2, the proliferation marker Ki-67, and human epidermal growth factor receptor 2 (HER2/neu). Correlations were calculated for expression of PGRMC1 and pPGRMC1 before and after neoadjuvant-therapy. PGRMC1 and pPGRMC1 were highly abundant in every breast cancer tissue sample. Considerably lower signals were detected in surrounding tissue. Further, PGRMC1 and pPGRMC1 abundance was found to correlate with ERβ expression. A lower level of pPGRMC1 could be found in post-therapy surgical specimens compared to specimens before treatment. Interestingly, patients with high PGRMC1 tumor levels showed worse response to anthracycline-based therapy as patients with lower PGRMC1 levels. These new findings demonstrate that PGRMC1 might play an important role in progression and therapy resistance of human breast tumors and could offer an interesting target for anticancer therapy.
Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus
Authors: Cheng Yuan-Bin , Liu Fan-Jin , Wang Chih-Hsin , Hwang Tsong-Long , Tsai Yung-Fong , Yen Chia-Hung , Wang Hui-Chun , Tseng Yen-Hsueh , Chien Ching-Te , Chen Yi-Ming , Chang Fang-Rong , Wu Yang-Chang 
Published: July 2017

AbstractPhytochemical investigation of the leaves and twigs of Lithocarpus litseifolius and Lithocarpus corneus resulted in the isolation of four new triterpenoids (1–4), three triterpenoids (5–7) isolated from a natural source for the first time, and six known compounds (8–13). In addition, four known triterpenoids (14–17) were isolated from L. corneus. Compound 1 is a 3,4-seco-lupane-type triterpenoid, and compounds 2–4 are lupane-type triterpenoids in different oxidation states. The structures of all isolated compounds were identified by spectroscopic methods, especially NMR and mass spectrometry data. The absolute configuration of 2 and 3 was confirmed by X-ray single crystallographic analysis. The anti-inflammatory activities of 1–17 and anti-HIV activities of 2–17 were evaluated. Among them, 3-epi-betulinic acid (8) showed a strong anti-HIV activity comparable to abacavir, a drug used for treating HIV/AIDS. 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid (5) exhibited potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 µM.
Microscopic dynamics of charge separation at the aqueous electrochemical interface
Authors: Kattirtzi John A. , Limmer David T. , Willard Adam P. 
Published: July 2017

Significance
Aqueous electrode interfaces serve as the backdrop for many important chemical processes in nature and technology. These interfaces continually garner much interest due to their ability to facilitate and even catalyze certain electrochemical reactions. Charge separation is a fundamental step in nearly all catalytic processes that occur at metal interfaces. Traditional electrochemical measurements are able to observe the consequences of charge separation but are limited in their ability to reveal direct molecular details. By studying detailed molecular models of charge transfer at water metal interfaces, we have uncovered the microscopic dynamics of this fundamental process. Elucidating the altered thermodynamics and kinetics of charge separation at water–metal interfaces and identifying their molecular underpinnings will inform the interpretation of macroscopic measurements and the design of better catalysts.
Genetic identification of a hindbrain nucleus essential for innate vocalization
Authors: Hernandez-Miranda Luis Rodrigo , Ruffault Pierre-Louis , Bouvier Julien C. , Murray Andrew J. , Morin-Surun Marie-Pierre , Zampieri Niccolò , Cholewa-Waclaw Justyna B. , Ey Elodie , Brunet Jean-Francois , Champagnat Jean , Fortin Gilles , Birchmeier Carmen 
Published: July 2017

Significance
Vocalization is a primary method of communication in many species and relies on coordinated muscle activity. Vocalization and breathing must be synchronized, because calls can be evoked only during expiration. How vocalization and breathing are coordinated is not well understood. Here, we show that newborn mice with impaired development of the nucleus tractus solitarius (NTS) are mute and cannot generate the expiratory pressure needed for vocalization. Furthermore, they do not receive appropriate maternal care. We demonstrate that the NTS contains premotor neurons that directly project to and entrain the activity of spinal (L1) and nucleus ambiguus motor neurons known to control expiratory pressure and laryngeal tension, respectively. We conclude that the NTS is an essential component of the vocal circuit.
Structure of the
Arabidopsis
TOPLESS corepressor provides insight into the evolution of transcriptional repression
Authors: Martin-Arevalillo Raquel , Nanao Max H. , Larrieu Antoine , Vinos-Poyo Thomas , Mast David , Galvan-Ampudia Carlos , Brunoud Géraldine , Vernoux Teva , Dumas Renaud , Parcy François 
Published: July 2017

Significance
In most biological processes, genes have to be activated and/or repressed. In plants, the TOPLESS protein is essential for gene repression through its action as a corepressor bridging transcription factor with chromatin remodeling complexes. Here we combine biochemical and structural studies to describe the structure of TOPLESS, how it tetramerizes, and how it interacts with its protein partners. We show that both the tetramerization interface and the binding site for protein partners have been conserved since algae, highlighting the ancestrality of TOPLESS function. Comparison of this plant protein with one of its animal counterparts also shows how corepressors can use a common domain differently to achieve similar properties, illustrating the tinkering of evolution in transcriptional repression.
BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation
Authors: Lewis Valerae O. , Devarajan Eswaran , Cardó-Vila Marina , Thomas Dafydd G. , Kleinerman Eugenie S. , Marchiò Serena , Sidman Richard L. , Pasqualini Renata , Arap Wadih 
Published: July 2017

Significance
In its metastatic/recurrent presentation, osteosarcoma is a high-risk tumor with poor management, essentially unchanged over the past 25 years. Osteosarcoma is a relatively rare cancer; however, because it affects predominantly teenagers and young adults, it is a leading disease-related cause of death and a major contributor to years of life lost in this age group. Here, we demonstrate the prognostic value of IL-11Rα in osteosarcoma progression and patient survival. We also report preclinical studies with the IL-11Rα–targeted peptidomimetic bone metastasis-targeting peptidomimetic (BMTP-11) as a therapeutic agent, either alone or in combination with gemcitabine, in both primary tumor and metastatic disease models. This study demonstrates successful applications directed against the IL-11Rα:IL-11 molecular axis in preclinical models of osteosarcoma.
Corticogeniculate feedback sharpens the temporal precision and spatial resolution of visual signals in the ferret
Authors: Hasse J. Michael , Briggs Farran 
Published: July 2017

Significance
The functional role of corticothalamic circuits, connecting the cortex to the thalamus in the feedback direction, has remained a fundamental mystery in neuroscience. In spite of the fact that corticothalamic inputs are numerous, their influence on thalamic activity is modest. We used an innovative combination of virus-mediated gene delivery and optogenetics to probe the function of corticothalamic feedback in vision. We found that corticothalamic feedback does not alter the visual response properties of thalamic neurons, but instead controls the timing and fidelity of their responses to incoming visual inputs. Thus, our results provide an answer to a long-standing question in neuroscience: A key function of corticothalamic feedback is to control the timing and precision of thalamic responses.
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
Authors: Wing James Badger , Kitagawa Yohko , Locci Michela , Hume Hannah , Tay Christopher , Morita Takayoshi , Kidani Yujiro , Matsuda Kyoko , Inoue Takeshi , Kurosaki Tomohiro , Crotty Shane , Coban Cevayir , Ohkura Naganari , Sakaguchi Shimon 
Published: July 2017

SignificanceT-follicular regulatory (Tfr) cells, a subset of Foxp3-expressing regulatory T (Treg) cells, have a critical role in the control of antibody responses. Whereas Treg cells express CD25 and are dependent on IL-2, Tfr cells also express the transcription factor BCL6 that is inhibited by IL-2 in T-follicular helper (Tfh) cells. In this report, we find that mature Tfr cells in the germinal centers or circulating in human blood down-regulate CD25 and gain a transcriptional signature mixed between Tfh cells and Treg cells while retaining their regulatory function. These cells represent an IL-2–independent branch of effector Treg cells losing CD25 expression but gaining increased expression of Tfh-related markers, such as BCL6 and CXCR5, in both mice and humans.
Bifunctionality of a biofilm matrix protein controlled by redox state
Authors: Arnaouteli Sofia , Ferreira Ana Sofia , Schor Marieke , Morris Ryan J. , Bromley Keith M. , Jo Jeanyoung , Cortez Krista L. , Sukhodub Tetyana , Prescott Alan R. , Dietrich Lars E. P. , MacPhee Cait E. , Stanley-Wall Nicola R. 
Published: July 2017

Significance
The biofilm matrix is a critical target in the hunt for novel strategies to destabilize or stabilize biofilms. Knowledge of the processes controlling matrix assembly is therefore an essential prerequisite to exploitation. Here, we highlight that the complexity of the biofilm matrix is even higher than anticipated, with one matrix component making two independent functional contributions to the community. The influence the protein exerts is dependent on the local environmental properties, providing another dimension to consider during analysis. These findings add to the evidence that bacteria can evolve multifunctional uses for the extracellular matrix components.
Are New Zealanders “rhotic”?
Authors: Marsden Sharon 
Published: July 2017

AbstractRhoticity is highly variable across English varieties. Traditionally, descriptions of English have distinguished between “rhotic” and “non-rhotic” varieties. However,Harris’s (2013)recent description of three core rhotic systems (R1, R2 and R3) demonstrates that this dichotomy is overly simplistic. The literature describes New Zealand English (NZE) as “non-rhotic”, with partial rhoticity in the lower South Island. This paper reports on data collected in two semi-rural towns in the North Island where young New Zealanders employ a “mixed” distribution of rhoticity. Alongside /r/ use which is traditionally associated with “non-rhotic” varieties (Harris’s R2 and R3), speakers also exhibit /r/ use which is associated with “rhotic” varieties (Harris’s R1). The findings suggest that dynamic rhoticity in NZE, which also persists historically in Englishes world-wide, can be represented more effectively by dispensing with the notions “rhotic” and “non-rhotic”, and by treating rhoticity as a continuum of /r/ use.
“Like getting nibbled to death by a duck”
Authors: Schwarz Sarah 
Published: July 2017

AbstractThis large-scale corpus study explores new parameters which might indicate grammaticalization of theget-passive in recent American English, where the construction has increased in frequency. To this end, large samples of bothbe- andget-passives from the TIME Magazine Corpus were analyzed with regard to tense, aspect, and situation type (Aktionsart). While tense and aspect preferences of the passives were diachronically stable, the results of the situation-type analysis were of interest for two reasons. First, they showed clear differences in the wayget- andbe-passives are used which reflect theget-passive’s inchoative origins. And second, the diachronic analysis of situation-type preferences forget-passives provides a first indication that they may be further grammaticalizing as they begin to behave more like canonicalbe-passives in the most recent data. This finding is tentatively supported by supplementary data from COHA.