bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arrhythmogenic gene remodelling in elderly patients with type 2 diabetes with aortic stenosis and normal left ventricular ejection fraction
Authors: Ashrafi R. , Modi P. , Oo A. Y. , Pullan D. M. , Jian K. , Zhang H. , Gerges J. Yanni , Hart G. , Boyett M. R. , Davis G. K. , Wilding J. P. H. 
Published: August 2017

New Findings
What is the central question of this study?
Type 2 diabetes is associated with a higher rate of ventricular arrhythmias compared with the non‐diabetic population, but the associated myocardial gene expression changes are unknown; furthermore, it is also unknown whether any changes are attributable to chronic hyperglycaemia or are a consequence of structural changes.

What is the main finding and its importance?
We found downregulation of left ventricular ERG gene expression and increased NCX1 gene expression in humans with type 2 diabetes compared with control patients with comparable left ventricular hypertrophy and possible myocardial fibrosis. This was associated with QT interval prolongation. Diabetes and associated chronic hyperglycaemia may therefore promote ventricular arrhythmogenesis independently of structural changes.

Type 2 diabetes is associated with a higher rate of ventricular arrhythmias, and this is hypothesized to be independent of coronary artery disease or hypertension. To investigate further, we compared changes in left ventricular myocardial gene expression in type 2 diabetes patients with patients in a control group with left ventricular hypertrophy. Nine control patients and seven patients with type 2 diabetes with aortic stenosis undergoing aortic valve replacement had standard ECGs, signal‐averaged ECGs and echocardiograms before surgery. During surgery, a left ventricular biopsy was taken, and mRNA expressions for genes relevant to the cardiac action potential were estimated by RT‐PCR. Mathematical modelling of the action potential and calcium transient was undertaken using the O'Hara–Rudy model using scaled changes in gene expression. Echocardiography revealed similar values for left ventricular size, filling pressures and ejection fraction between groups. No difference was seen in positive signal‐averaged ECGs between groups, but the standard ECG demonstrated a prolonged QT interval in the diabetes group. Gene expression of KCNH2 and KCNJ3 were lower in the diabetes group, whereas KCNJ2, KCNJ5 and SLC8A1 expression were higher. Modelling suggested that these changes would lead to prolongation of the action potential duration with generation of early after‐depolarizations secondary to a reduction in density of the rapid delayed rectifier K+ current and increased Na+–Ca2+ exchange current. These data suggest that diabetes leads to pro‐arrythmogenic changes in myocardial gene expression independently of left ventricular hypertrophy or fibrosis in an elderly population.
Dopant occupancy and UV-VIS-NIR spectroscopy of Mg (0, 4, 5 and 6 mol.%):Dy:LiNbO3crystal
Authors: Dai Li , Liu Chunrui , Han Xianbo , Wang Luping , Tan Chao , Yan Zhehua , Xu Yuheng 
Published: August 2017

A series of Dy:LiNbO3crystals with x mol.% Mg[Formula: see text] ions (x =0, 4, 5 and 6 mol.%) were grown by the Czochralski method. The effective segregation coefficient of Mg[Formula: see text] and Dy[Formula: see text] ions was studied by the inductively coupled plasma-atomic emission spectrometry (ICP-AES). UV-VIS-NIR absorption spectra and Judd–Ofelt theory were used to investigate their spectroscopic properties. J–O intensity parameters ([Formula: see text], [Formula: see text], and [Formula: see text]) and larger spectroscopic quality factor (X = 2.26) for Mg:(6 mol.%)Dy:LiNbO3crystals were obtained.
The Brazilian Science Data Center (BSDC)
Authors: de Almeida Ulisses Barres , Bodmann Benno , Giommi Paolo , Brandt Carlos H. 
Published: August 2017

Astrophysics and Space Science are becoming increasingly characterised by what is now known as “big data”, the bottlenecks for progress partly shifting from data acquisition to “data mining”. Truth is that the amount and rate of data accumulation in many fields already surpasses the local capabilities for its processing and exploitation, and the efficient conversion of scientific data into knowledge is everywhere a challenge. The result is that, to a large extent, isolated data archives risk being progressively likened to “data graveyards”, where the information stored is not reused for scientific work. Responsible and efficient use of these large data-sets means democratising access and extracting the most science possible from it, which in turn signifies improving data accessibility and integration. Improving data processing capabilities is another important issue specific to researchers and computer scientists of each field. The project presented here wishes to exploit the enormous potential opened up by information technology at our age to advance a model for a science data center in astronomy which aims to expand data accessibility and integration to the largest possible extent and with the greatest efficiency for scientific and educational use. Greater access to data means more people producing and benefiting from information, whereas larger integration of related data from different origins means a greater research potential and increased scientific impact. The project of the BSDC is preoccupied, primarily, with providing tools and solutions for the Brazilian astronomical community. It nevertheless capitalizes on extensive international experience, and is developed in full cooperation with the ASI Science Data Center (ASDC), from the Italian Space Agency, granting it an essential ingredient of internationalisation. The BSDC is Virtual Observatory-complient and part of the “Open Universe”, a global initiative built under the auspices of the United Nations.
REMARKS ON WITTGENSTEIN’S PHILOSOPHY: PRIVATE LANGUAGE AND MEANING
Authors: Hansen Kaj Børge 
Published: August 2017

This essay is a critical analysis of some themes in Wittgenstein’s later philosophy. It is not primarily Wittgenstein-exegesis. Much more modestly, my purpose is to express my own thoughts about some questions which Wittgenstein has treated in his writings. It is the first in a series of two articles. The second article, “Remarks on Wittgenstein’s Philosophy: Philosophical Method and Contradictions”, will occur in next year’s issue of the present YEARBOOK.

Section 1, “The Private Language Argument”. An independent argument is given for Wittgenstein’s thesis that there is no private language. I show that psychological terms in ordinary language, in contrast to an implication of Wittgenstein’s own private language argument, in their meanings do contain references to inner states, processes, or events.

Section 2, “Meaning”. Wittgenstein’s definition of meaning as use in the language is criticised. Meaning is instead identified with something in the content of a conscious mind. Applications are given to some suggestions in philosophy of language by Chomsky, Grice, Harman and Fodor, and Kripke.
For orientation, I also include here the abstract for the second article, “Remarks on Wittgenstein’s Philosophy: Philosophical Method and Contradictions”.

Section 1, “Philosophical Method”. Wittgenstein’s conception of philosophy as language therapy is criticised. Instead philosophy is construed as foundational research. Wittgenstein’s statement that mathematical logic cannot contribute to progress in philosophy is repudiated. Several examples of ideas and results in mathematical logic which have led to the solution of philosophical problems are given.

Section 2, “Contradictions: The Wittgenstein-Turing Debate”. In lectures on the foundations of mathematics given in 1939, Wittgenstein claimed that contradictions in mathematical theories are harmless. A debate ensued on this question between him and Alan Turing. In support of Turing’s standpoint, I use the theorem on Taylor series, Church’s Theorem, and Gentzen’s Cut-Elimination Theorem to show that Wittgenstein’s standpoint is untenable.
Comparing the prevalence and the risk profile for antenatal depressive symptoms across cultures
Authors: Corbani Irene E , Rucci Paola , Iapichino Elena , Quartieri Bollani Marta , Cauli Gilla , Ceruti Mara R , Gala Costanzo , Bassi Mariano 
Published: August 2017

Background and aims: Although several studies have analyzed the risk factors of antenatal and post-partum depression, evidence on the prevalence and the risk profile for antenatal depressive symptoms (ADS) between native-born and different groups of non-native born women living in the same country is scant. The aim of this article is to compare the prevalence and the risk profile for ADS across geographical areas in women recruited from two large hospitals of North-western Italy. Method: The presence of ADS was defined as an Edinburgh Post-natal Depression Scale (EPDS) score ≥12 or a Beck Depression Inventory, Short Form (BDI-SF) score ≥9 or the presence of suicidal ideation/behavior. Crude and adjusted odds ratios (ORs) of ADS were calculated using logistic regression models. Results: The prevalence of ADS was 12.4% among Italian women and ranged from 11.4% in other European to 44.7% in North-African women. Crude ORs of ADS were OR = 3.3 (95% confidence interval (CI), 1.2–8.8) for Asian, 3.3 (95% CI, 1.9–5.6) for South-American and 5.7 (95% CI, 3.4–9.6) for North-African women. Marital problems, at-risk pregnancy, past psychiatric history, pharmacological treatment, psychological treatment, financial problems, change in residence and number of children were significantly associated with ADS in multivariate analyses, regardless of women’s origin. After adjusting for these variables, the OR of ADS remained significant for South-American and North-African women. Conclusion: Our results demonstrate that the risk of ADS varies across geographical areas of origin and is highest among North-African women. The risk factors identified should be assessed in routine obstetric care to inform decisions about interventions to prevent post-partum depression and its consequences on the mothers and the newborns.
Critical Shoulder Angle and Acromial Index Do Not Influence 24-Month Functional Outcome After Arthroscopic Rotator Cuff Repair
Authors: Lee Merrill , Chen Jerry Yongqian , Liow Ming Han Lincoln , Chong Hwei Chi , Chang Paul , Lie Denny 
Published: August 2017

Background:Recent studies have shown a correlation between scapular geometry and the development of atraumatic rotator cuff tears. However, a paucity of literature is available on the effects of critical shoulder angle (CSA) and acromial index (AI) on functional outcomes after arthroscopic rotator cuff repair.Hypothesis/Purpose:The purpose was to investigate the influence of CSA and AI on 24-month functional outcomes after arthroscopic rotator cuff repair. The hypothesis was that a larger CSA or AI would result in poorer postoperative outcomes.Study Design:Cohort study; Level of evidence, 3.Methods:The study included 147 patients who underwent arthroscopic double-row rotator cuff repair for radiologically documented full-thickness supraspinatus tears. An independent reviewer measured the CSA and AI on preoperative radiographs. These patients were prospectively enrolled and were evaluated preoperatively as well as at 3, 6, 12, and 24 months postoperatively. Functional outcome was assessed with the Constant Shoulder Score (CSS), Oxford Shoulder Score (OSS), and University of California at Los Angeles (UCLA) Shoulder Rating Scale. The patients were first divided based on CSA: (1) ≤35° (control CSA) and (2) >35° (increased CSA); and then based on AI: (1) ≤0.7 and (2) >0.7. The Student unpaired t test, Pearson chi-square test, and Pearson correlation were performed to examine the influence of CSA and AI on postoperative functional outcome scores.Results:At 6 months of follow-up, the CSS, OSS, and UCLA Shoulder Rating Scale were 10 ± 1, 4 ± 2, and 3 ± 1 points poorer in the increased CSA group compared with the control CSA group ( P = .005, P = .030, and P = .035, respectively). These scores were not significantly different between both AI groups. By 24 months of follow-up, all outcome scores were comparable between both CSA groups as well as between both AI groups. No significant correlation was found between either CSA or AI when compared with CSS, OSS, or UCLA Shoulder Rating Scale at 24 months of follow-up.Conclusion:CSA and AI do not appear to influence 24-month functional outcomes postoperatively and hence are not contraindications to arthroscopic rotator cuff repair.
Comparing the New York State Smokers’ Quitline Reach, Services Offered, and Quit Outcomes to 44 Other State Quitlines, 2010 to 2015
Authors: Mann Nathan , Nonnemaker James , Chapman LeTonya , Shaikh Asma , Thompson Jesse , Juster Harlan 
Published: August 2017

Purpose: To summarize the reach, services offered, and cessation outcomes of the New York Quitline and compare with other state quitlines. Design: Descriptive study. Setting: Forty-five US states. Participants: State-sponsored tobacco cessation quitlines in 45 US states that provided complete data to the Centers for Disease Control and Prevention’s National Quitline Data Warehouse (NQDW) for 24 quarters over 6 years (2010-Q1 through 2015-Q4). Intervention: Telephone quitlines that offer tobacco use cessation services, including counseling, self-help materials, and nicotine replacement therapy (NRT), to smokers at no cost to them. Measures: Percentage of adult tobacco users in the state who received counseling and/or free NRT from state quitlines (reach), services offered by state quitlines, and cessation outcomes among quitline clients 7 months after using quitline services. Analysis: Reach, services offered, and cessation outcomes for the New York Quitline were compared with similar measures for the other 44 state quitlines with complete NQDW data for all quarters from 2010 through 2015. Results: New York’s average annual quitline reach from 2010 through 2015 was 3.0% per year compared to 1.1% per year for the other 44 states examined. Conclusion: Although the New York Quitline was open fewer hours per week and offered fewer counseling sessions and a smaller amount of free NRT than most of the other 44 state quitlines, the New York Quitline had similar quit rates to most of those state quitlines.
Probable Rivaroxaban-Induced Full Body Rash: A Case Report
Authors: Sasson Evan , James Marian , Russell Mark , Todorov Darko , Cohen Henry 
Published: August 2017

Introduction: Rivaroxaban is a novel oral anticoagulant with several indications, one of which is for stroke prevention in nonvalvular atrial fibrillation. We present a case of probable rivaroxaban-induced rash. Case Summary: A 79-year-old female with a medical history of atrial fibrillation experienced a stroke, after which she was prescribed rivaroxaban 20 mg. After several days, she developed a rash requiring admission to the emergency department and several days of treatment. The rash resolved and she was switched from rivaroxaban to apixaban and did not experience any adverse drug events. Discussion: Onset of symptoms occurred within days of rivaroxaban initiation. The patient had no allergy history and never reported a similar reaction while on concurrent home medication regimen. The resolution of rash and toleration of apixaban suggest a rivaroxaban-specific reaction. The mechanism of this rash is currently unclear. Conclusion: We report one of the first cases of probable rivaroxaban-induced rash, whereas the patient tolerated apixaban. Further investigation is warranted, but prescribers should be cognizant of this potential issue when choosing a factor Xa inhibitor for anticoagulation.
Evaluation of Direct-Acting Oral Anticoagulant Use in Patients With Cancer
Authors: Davis Daphne O. , Davis Kyle A. 
Published: August 2017

Purpose: To evaluate the use of direct-acting oral anticoagulants in patients with cancer and venous thromboembolism (VTE) treated at Ochsner Medical Center with the intent of determining the efficacy and safety of these agents. Methods: Patients were identified by a retrospective data extraction of patients treated at Ochsner Medical Center from January 1, 2013, through December 31, 2015. Patients were included for review if they were ≥18 years of age, with a confirmed diagnosis of VTE and active or history of cancer, and if they received dabigatran, apixaban, rivaroxaban, or edoxaban for at least 6 months. The primary objectives were the rate of recurrence of VTE and the incidence of bleeding at 6 months. Results: Thirty-seven patients were identified. Twelve patients were diagnosed with PE, 21 with DVT, 3 with DVT and PE, and 1 with DVT and superficial vein thrombosis (SVT). Apixaban was used most often (n = 27). No patients experienced a recurrent DVT or PE at 6 months. Two patients experienced adverse effects during treatment. Conclusions: In this single-center, retrospective, observational study in patients with cancer receiving DOAC therapy, there were no episodes of recurrent VTE and only 2 episodes of clinically significant bleeding.
Socioeconomic Disparities in Smoking Behavior and Early Smoking Initiation Among Men in Malawi
Authors: Yaya Sanni , Bishwajit Ghose , Shah Vaibhav , Ekholuenetale Michael 
Published: August 2017

Background: Tobacco smoking is a growing concern for health care systems as it is projected to become the leading cause of death in the developing world. Knowledge of how smoking behavior differs across socioeconomic groups is crucial for designing effective preventive policies and alleviating the disparities. The aim of this study was to report the prevalence of (1) smoking status, (2) early smoking initiation, and (3) association with socioeconomic status (SES) of the 2 among Malawian men. Methods: Cross-sectional data on 1693 men aged between 15 and 49 years were collected from the latest 2013-2014 Multiple Indicator Cluster Survey in Malawi. Educational qualification and wealth index quintile were used as the indicators of SES. Outcome variables were smoking status, first age of smoking being below 18 years, and ever using any form of smokeless tobacco products. Multiple logistic regression models were used to see the contribution of SES to smoking status and early smoking initiation. Results: Mean age of the sample population was 33.23 years (SD: 8.25). Prevalence of smoking, early initiation, and ever using any form of smokeless tobacco were, respectively, 46.6%, 33.7%, and 6%. Compared with men who had higher education, those who had no formal education, primary-level, and secondary-level qualification had, respectively, 21% (adjusted odds ratio [AOR] = 1.209; 95% confidence interval [CI] = 0.498-2.935), 40% (AOR = 1.4; 95% CI = 0.647-3.029), and 26% (AOR = 1.256; 95% CI = 0.593-2.661) higher odds of being a smoker. Those who had no formal education were 2.7 times (AOR = 2.734; 95% CI = 1.123-6.653) as likely to try smoking before reaching 18 years of age. Compared with the richest, those in the lowest wealth quintile had 32% lower odds (AOR = 0.676; 95% CI = 0.455-1.006) of early onset of smoking, 63% lower odds (AOR = 0.372; 95% CI = 0.201-0.690) of trying other tobacco products. Conclusions: Addressing the socioeconomic disparities could play a vital role in delaying early onset and limiting overall consumption of tobacco. Ongoing health policy talks to reduce the prevalence of smoking should take into consideration improving educational and material well-being among men.
Air pollution is associated to the multiple sclerosis inflammatory activity as measured by brain MRI
Authors: Bergamaschi Roberto , Cortese Andrea , Pichiecchio Anna , Berzolari Francesca Gigli , Borrelli Paola , Mallucci Giulia , Bollati Valentina , Romani Alfredo , Nosari Guido , Villa Silvia , Montomoli Cristina 
Published: August 2017

Background: Some environmental factors have been already associated to increased risk of multiple sclerosis (MS), but it is plausible that additional factors might play a role. Objective: To investigate in MS patients the relationship between inflammatory activity, detected by brain magnetic resonance imaging (MRI) with gadolinium (Gd), and air pollution, namely, particulate matters with diameter less than 10 μm (PM10). Methods: We analyzed from 52 remitting MS patients 226 brain MRIs, 34% with (Gd+MRI) and 66% without (Gd-MRI) T1-Gd-enhancing lesions. Daily recording of PM10 in the 30 days before MRI examination was obtained by monitors depending on the residence of subjects. Results: PM10 levels in the 5, 10, 15, 20, and 25 days before brain MRIs were higher (plus 16%, 21%, 24%, 25%, and 21%, respectively) with reference to Gd+MRI versus Gd-MRI. There was a significant association between Gd+MRI and PM10 levels ( p = 0.013), independent of immune therapies, smoker status, and season. In patients who had two repeated MRIs with opposite outcomes (Gd-MRI and Gd+MRI), PM10 levels were strongly higher in concurrence with Gd+MRI ( p < 0.0001). Conclusion: Our findings suggest that air pollution may be a risk factor for MS favoring inflammatory exacerbations.
The effect of a peer support intervention on early recovery outcomes in men recovering from coronary bypass surgery: A randomized controlled trial
Authors: Colella Tracey JF , King-Shier Kathryn 
Published: August 2017

Background and aim: Examine the effect of a professionally-guided telephone peer support intervention on recovery outcomes including depression, perceived social support, and health services utilization after coronary artery bypass graft surgery (CABG). Methods: A randomized controlled trial was conducted with post-coronary artery bypass graft surgery men ( N=185) who were randomized before hospital discharge. The intervention arm received telephone-based peer support through weekly telephone calls from a peer volunteer over six weeks, initiated within 3–4 days of discharge. Results: Although a significant difference was detected in pre-intervention depression scores at discharge, there were no differences between groups in changes in depression scores at six weeks ( p=0.08), 12 weeks (0.49) or over time ( p=0.51); and no significant differences in perceived social support scores over time ( p=0.94). At 12 weeks, the intervention group had significantly lower incidence of health services utilization (family physician ( p=0.02) and emergency room ( p=0.04)). Conclusions: Healthcare providers need to continue to investigate novel interventions to enhance social support and reduce depression in cardiac patients.