bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-Cigarette Marketing Online: A Systematic Content Analysis of Manufacturers and Retailers
Authors: Klein EG , Berman M , Hemmerich N , Carlson C , Htut S , Slater M 
Published: March 2016

Abstract
Purpose: To identify the current atmosphere of online sales of Electronic Nicotine Delivery Systems (ENDS) in regards to key health-related and legal claims being made and to analyze the legal framework for regulating such claims. Methods: In December 2014, a systematic search protocol was employed with 3 popular search engines using six terms: 1) e-cigarettes, 2) e-cigs, 3) e-juice, 4) e-liquid, 5) e-hookah, and 6) vape pen. Websites from ENDS manufacturers and retailers were eligible for inclusion, and excluded review sites, blogs, or other non-commercial sites. Three pages of content were examined for each search term. In Phase I, included sites were independently coded for several health-related and legal themes, including: Modified or Reduced Risk, Cessation, Smoke anywhere, Health Benefits, Cleanliness, Environmentally Friendly, and Modern. In Phase II, gathered qualitative data was further coded for primary (explicit) and secondary (implicit) claims. Results: The final web search (n = 115) identified eligible sites and these were divided into two categories Manufacturers (n = 78) and Retailers (n = 32). Between both groups, the most common claims were Modified or reduced risk claims (63.6%), Cessation claims (41.8%), and Claims regarding one's ability to get around clean indoor air laws (42.7%) for Manufacturers and Retailers, combined. Overall, Manufacturers were more likely to make any health or legal claim than Retailers. Conclusions: The unregulated marketing of ENDS has led to a proliferation of health-related claims. Applying a legal/regulatory perspective, this research reveals the different types of health-related claims being made by ENDS manufacturers and retailers on their websites. For claims that are misleading or deceptive, the specifics content and context of each claim may influence whether the FDA has the current regulatory authority to address it. This research demonstrates that the FDA should complete the proposed “deeming” rule and develop a comprehensive regulatory scheme to addresses health-related claims by ENDS manufacturers and retailers.
Entrectinib, a Pan–TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications
Authors: Ardini Elena , Menichincheri Maria , Banfi Patrizia , Bosotti Roberta , De Ponti Cristina , Pulci Romana , Ballinari Dario , Ciomei Marina , Texido Gemma , Degrassi Anna , Avanzi Nilla , Amboldi Nadia , Saccardo Maria Beatrice , Casero Daniele , Orsini Paolo , Bandiera Tiziano , Mologni Luca , Anderson David , Wei Ge , Harris Jason , Vernier Jean-Michel , Li Gang , Felder Eduard , Donati Daniele , Isacchi Antonella , Pesenti Enrico , Magnaghi Paola , Galvani Arturo 
Published: March 2016

Abstract
Activated ALK and ROS1 tyrosine kinases, resulting from chromosomal rearrangements, occur in a subset of non–small cell lung cancers (NSCLC) as well as other tumor types and their oncogenic relevance as actionable targets has been demonstrated by the efficacy of selective kinase inhibitors such as crizotinib, ceritinib, and alectinib. More recently, low-frequency rearrangements of TRK kinases have been described in NSCLC, colorectal carcinoma, glioblastoma, and Spitzoid melanoma. Entrectinib, whose discovery and preclinical characterization are reported herein, is a novel, potent inhibitor of ALK, ROS1, and, importantly, of TRK family kinases, which shows promise for therapy of tumors bearing oncogenic forms of these proteins. Proliferation profiling against over 200 human tumor cell lines revealed that entrectinib is exquisitely potent in vitro against lines that are dependent on the drug's pharmacologic targets. Oral administration of entrectinib to tumor-bearing mice induced regression in relevant human xenograft tumors, including the TRKA-dependent colorectal carcinoma KM12, ROS1-driven tumors, and several ALK-dependent models of different tissue origins, including a model of brain-localized lung cancer metastasis. Entrectinib is currently showing great promise in phase I/II clinical trials, including the first documented objective responses to a TRK inhibitor in colorectal carcinoma and in NSCLC. The drug is, thus, potentially suited to the therapy of several molecularly defined cancer settings, especially that of TRK-dependent tumors, for which no approved drugs are currently available. Mol Cancer Ther; 15(4); 628–39. ©2016 AACR.
ABO Blood Group and Risk of Thromboembolic and Arterial Disease
Authors: Vasan Senthil K. , Rostgaard Klaus , Majeed Ammar , Ullum Henrik , Titlestad Kjell-Einar , Pedersen Ole B.V. , Erikstrup Christian , Nielsen Kaspar Rene , Melbye Mads , Nyrén Olof , Hjalgrim Henrik , Edgren Gustaf 
Published: March 2016

Background—
ABO blood groups have been shown to be associated with increased risks of venous thromboembolic and arterial disease. However, the reported magnitude of this association is inconsistent and is based on evidence from small-scale studies.

Methods and Results—
We used the SCANDAT2 (Scandinavian Donations and Transfusions) database of blood donors linked with other nationwide health data registers to investigate the association between ABO blood groups and the incidence of first and recurrent venous thromboembolic and arterial events. Blood donors in Denmark and Sweden between 1987 and 2012 were followed up for diagnosis of thromboembolism and arterial events. Poisson regression models were used to estimate incidence rate ratios as measures of relative risk. A total of 9170 venous and 24 653 arterial events occurred in 1 112 072 individuals during 13.6 million person-years of follow-up. Compared with blood group O, non-O blood groups were associated with higher incidence of both venous and arterial thromboembolic events. The highest rate ratios were observed for pregnancy-related venous thromboembolism (incidence rate ratio, 2.22; 95% confidence interval, 1.77–2.79), deep vein thrombosis (incidence rate ratio, 1.92; 95% confidence interval, 1.80–2.05), and pulmonary embolism (incidence rate ratio, 1.80; 95% confidence interval, 1.71–1.88).

Conclusions—
In this healthy population of blood donors, non-O blood groups explain >30% of venous thromboembolic events. Although ABO blood groups may potentially be used with available prediction systems for identifying at-risk individuals, its clinical utility requires further comparison with other risk markers.
Effect of Reference Scheme on Power and Phase of the Local Field
Potential
Authors: Shirhatti Vinay , Borthakur Ayon , Ray Supratim 
Published: March 2016

Abstract
Brain signals are often analyzed in the spectral domain, where the power spectral density (PSD) and phase differences and consistency can reveal important information about the network. However, for proper interpretation, it is important to know whether these measures depend on stimulus/behavioral conditions or the reference scheme used to analyze data. We recorded local field potential (LFP) from an array of microelectrodes chronically implanted in area V1 of monkeys under different stimulus/behavioral conditions and computed PSD slopes, coherence, and phase difference between LFPs as a function of frequency and interelectrode distance while using four reference schemes: single wire, average, bipolar, and current source density. PSD slopes were dependent on reference scheme at low frequencies (below 200 Hz) but became invariant at higher frequencies. Average phase differences between sites also depended critically on referencing, switching from 0 degrees for single-wire to 180 degrees for average reference. Results were consistent across different stimulus/behavioral conditions. We were able to account for these results based on the coherence profile across sites and properties of the spectral estimator. Our results show that using different reference schemes can have drastic effects on phase differences and PSD slopes and therefore must be interpreted carefully to gain insights about network properties.
Why symbolic representation frames parliamentary public engagement
Authors: Leston-Bandeira Cristina 
Published: March 2016

Research Highlights and Abstract The UK Parliament’s activity in public engagement has recently expanded considerably. Faced with declining levels of trust, it has invested considerable time and resources to new activities focusing specifically on engagement: educational resources and cultural events among many others. This embodies a new role for parliament of increasing importance particularly in the context of the 21st-century parliament. But it is an area that still requires further study, as we know little about the role performed by parliamentary public engagement. This article explores the institution’s aims in developing public engagement and reflects on the extent to which this embodies elements of symbolic representation. We utilise different theories on representation to develop a framework to understand the role played by public engagement in the 21st-century context. We then employ this perspective to analyse the aims and characteristics of public engagement activity in the UK Parliament. Besides a normative reflection on representation and engagement, our article is based on qualitative research which included elite in-depth interviews with parliamentary officials complemented by documentary analysis. Our research shows that public engagement planning in the UK Parliament aims to develop among the public a sense of connectivity that relies on more collective and symbolic forms of representation, which seek to present the institution detached from its actors and politics. The UK Parliament’s activity in public engagement has recently expanded considerably. Faced with declining levels of trust, it has invested considerable time and resources to new activities focusing specifically on engagement: educational resources and cultural events among many others. This embodies a new role for parliament of increasing importance particularly in the context of the 21st-century parliament. This article analyses the aims of public engagement and its consequences for representation. We explore the potential representative role of public engagement, identifying key changes that have affected the relationship between public and parliament. We utilise evidence from documentary analysis and elite in-depth interviews with parliamentary officials to show that public engagement planning aims to develop among the public a sense of connectivity that relies on more collective and symbolic forms of representation, which seek to present the institution detached from its actors and politics. We utilise constructivist representation theories to support our analysis.
Extracorporeal membrane oxygenation for failed tPA therapy of pulmonary embolism
Authors: Newman Joshua , Park David , Manetta Frank 
Published: March 2016

Background: Pulmonary embolism may cause cardiac arrest secondary to obstruction of blood flow. Traditional treatment strategies include anticoagulation, thrombolysis, and mechanical extraction. Some advocate for support with extra corporeal membrane oxygenation; however, surgical therapies are contraindicated following thrombolytics. Methods: We describe the emergent use of peripheral extra corporeal membrane oxygenation following thrombolytic therapy for a saddle pulmonary embolism associated with multiple episodes of cardiac arrest. Results: The patient was stabilized with peripheral extra corporeal membrane oxygenation, anticoagulated and subsequently weaned from extra corporeal membrane oxygenation without any major bleeding complications. Conclusion: The administration of thrombolytics should not be a contraindication for extra corporeal membrane oxygenation in patients with massive pulmonary embolism associated with hemodynamic instability.
1-year follow-up of neurofeedback treatment in adolescents with attention-deficit hyperactivity disorder: randomised controlled trial
Authors: Bink Marleen , Bongers Ilja L. , Popma Arne , Janssen Tieme W. P. , Nieuwenhuizen Chijs van 
Published: March 2016

BackgroundEstimates of the effectiveness of neurofeedback as a treatment for attention-deficit hyperactivity disorder (ADHD) are mixed.AimsTo investigate the long-term additional effects of neurofeedback (NFB) compared with treatment as usual (TAU) for adolescents with ADHD.MethodUsing a multicentre parallel-randomised controlled trial design, 60 adolescents with a DSM-IV-TR diagnosis of ADHD receiving NFB+TAU (n=41) or TAU (n=19) were followed up. Neurofeedback treatment consisted of approximately 37 sessions of theta/sensorimotor rhythm (SMR)-training on the vertex (Cz). Outcome measures included behavioural self-reports and neurocognitive measures. Allocation to the conditions was unmasked.ResultsAt 1-year follow-up, inattention as reported by adolescents was decreased (range ηp2=0.23–0.36, P<0.01) and performance on neurocognitive tasks was faster (range ηp2=0.20–0.67, P<0.005) irrespective of treatment group.ConclusionsOverall, NFB+TAU was as effective as TAU. Given the absence of robust additional effects of neurofeedback in the current study, results do not support the use of theta/SMR neurofeedback as a treatment for adolescents with ADHD and comorbid disorders in clinical practice.
Numerical Assessment of a One-Mass Spring-Based Electromagnetic Energy Harvester on a Vibrating Object
Authors: Chiu Min-Chie , Chang Ying-Chun , Yeh Long-Jyi , Chung Chiu-Hung 
Published: March 2016

Abstract
The paper is an exploration of the optimal design parameters of a space-constrained electromagnetic vibration-based generator. An electromagnetic energy harvester is composed of a coiled polyoxymethylen circular shell, a cylindrical NdFeB magnet, and a pair of helical springs. The magnet is vertically confined between the helical springs that serve as a vibrator. The electrical power connected to the coil is actuated when the energy harvester is vibrated by an external force causing the vibrator to periodically move through the coil. The primary factors of the electrical power generated from the energy harvester include a magnet, a spring, a coil, an excited frequency, an excited amplitude, and a design space. In order to obtain maximal electrical power during the excitation period, it is necessary to set the system’s natural frequency equal to the external forcing frequency. There are ten design factors of the energy harvester including the magnet diameter (Dm), the magnet height (Hm), the system damping ratio (ζsys), the spring diameter (Ds), the diameter of the spring wire (ds), the spring length (ℓs), the pitch of the spring (ps), the spring’s number of revolutions (Ns), the coil diameter (Dc), the diameter of the coil wire (dc), and the coil’s number of revolutions (Nc). Because of the mutual effects of the above factors, searching for the appropriate design parameters within a constrained space is complicated. Concerning their geometric allocation, the above ten design parameters are reduced to four (Dm, Hm, ζsys, and Nc). In order to search for optimal electrical power, the objective function of the electrical power is maximized by adjusting the four design parameters (Dm, Hm, ζsys, and Nc) via the simulated annealing method.
Consequently, the optimal design parameters of Dm, Hm, ζsys, and Nc that produce maximum electrical power for an electromagnetic energy harvester are found.
Theoretical and experimental analysis of scan angle-depending pulse front tilt in optical systems for laser scanners
Authors: Büsing Lasse , Bonhoff Tobias , Behnke Lars , Stollenwerk Jochen , Loosen Peter 
Published: March 2016

Abstract
For realising fast and highly dynamical laser-based material processing, scanner systems are already utilised for many different industrial applications. Furthermore, ultra-short pulsed (<1 ps) laser sources provide possibilities of processing most different materials with highest accuracy. Owing to the large spectral bandwidth of ultra-short laser pulses, dispersion in optical components becomes relevant. The dispersion in optical systems for laser scanners may lead to scan angle-depending pulse properties as, for example, pulse front tilt. The investigation of these effects is not state of the art today but absolutely necessary to exploit the full potential of laser scanners for ultra-short pulse applications. By means of an exemplary focusing lens, the simulation and experimental analysis of scan angle-depending pulse front tilt is presented for the first time.
Placental massive perivillous fibrinoid deposition is associated with adverse pregnancy outcomes: a clinicopathological study of 12 cases
Authors: Qi Maili , En Chang Kenneth Tou , Quan Lian Derrick Wen , Khoo Chong Kiat , Tan Kok Hian 
Published: March 2016

Abstract

Introduction: Massive perivillous fibrinoid deposition (MPFD) is a very rare placental condition characterized by abnormally extensive fibrinoid deposition in the placental villous parenchyma. The aim of this study is to document clinical and pathological features with special focus on pregnancy outcomes of this condition in consecutive cases of MPFD in our local population.

Methods: This is a retrospective clinico-pathological study of cases affected by MPFD over the period January 2010–July 2014 in our hospital. We document clinical features (including perinatal outcome and subsequent pregnancies) and placental pathological characteristics.

Results: Twelve cases of MPFD were identified among 3640 placentas (0.33%). There was no identified recurrence. The affected infants had adverse outcomes, including intrauterine growth restriction (IUGR) (75%), preterm birth (58.3%), and fetal loss (25%). A high frequency of reduced PAPP-A in the first trimester (25%), and concurrent gestational hypertension or pre-eclampsia (25%) was noted.

Conclusion: MPFD is associated with adverse perinatal outcomes. Further research to better understand its pathogenesis and to improve clinical diagnosis and management is warranted.
Convergence of modified S-iteration process for two asymptotically quasi-nonexpansive type mappings in CAT(0) spaces
Authors: Saluja G. S. 
Published: March 2016

Abstract
The purpose of this paper is to study convergence of a newly defined modified S-iteration process to a common fixed point of two asymptotically quasi-nonexpansive type mappings in the setting of CAT(0) space. We give a suffcient condition for convergence to a common fixed point and establish some strong convergence theorems for the said iteration process and mappings under suitable conditions. Our results extend and improve many known results from the existing literature.
Vashti and Sita: The Daring Sisters We Could Trust
Authors: Kebaneilwe Mmapula D. , Motswapong Pulane E. 
Published: March 2016

Abstract
The aim of this paper is to make a comparison between two female figures from two different religions. Vashti is one of the unsung heroines in the Book of Esther in the Hebrew Bible, while Sita in the Book of Ramayana is a revered female figure among Hindus. The tales of these women seem to display similarities in the ideals they embody and hence we endeavour to read them together. We wish to explore the extent to which Vashti and Sita’s tales of female courage and daring could inspire women today who continue to suffocate under oppressive patriarchal contexts. This is relevant to the context of Botswana, where despite global efforts to bend gender-based inequality, women continue to be victimised.
Interrogating Urban Spaces: Kali and the Intellectual in two Contemporary Novels
Authors: Raducanu Adriana 
Published: March 2016

Abstract
This article focuses on the complexity of the encounter between two Western male writers and the East as represented by the metropolis of Calcutta and Kali, its patron goddess. The novels under discussion are Dan Simmons’ Song of Kali and Paul Theroux’s A Dead Hand: A Crime in Calcutta. The theoretical framework of the comparative analysis argues for the conceptual blurring of boundaries between ‘flâneur’ and ‘badaud’, elusive hypostases of the male writer protagonists in the Eastern urban context.
Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review
Authors: Brilland Benoit , Sayegh Johnny , Croue Anne , Bridoux Frank , Subra Jean-François , Augusto Jean-François 
Published: March 2016

Light chain deposition disease (LCDD) is a rare multisystemic disorder associated with plasma cell proliferation. It mainly affects the kidney, but liver and heart involvement may occur, sometimes mimicking the picture of systemic amyloidosis. Liver disease in LCDD is usually asymptomatic and exceptionally manifests with severe cholestatic hepatitis. We report the case of a 66-year-old female with κ-LCDD and cast nephropathy in the setting of symptomatic multiple myeloma who, after a first cycle of bortezomib-dexamethasone chemotherapy, developed severe and rapidly worsening intrahepatic cholestasis secondary to liver κ-light chain deposition. Intrahepatic cholestasis was attributed to LCDD on the basis of the liver histology and exclusion of possible diagnoses. Chemotherapy was maintained and resulted in progressive resolution of cholestasis. We report here an uncommon presentation of LCDD, with prominent liver involvement that fully recovered with bortezomib-based chemotherapy, and briefly review the relevant literature.
Abbreviations: AKI: Acute kidney injury; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; CMV: Cytomegalovirus; EBV: Epstein–Barr virus; GGT: gamma-glutamyl transferase; HSV: Herpes simplex virus; LC: light chain; LCDD: Light chain deposition disease; MIDD: Monoclonal immunoglobulin deposition disease; MM: Multiple myeloma.
Neoliberalismo socioeconômico e mutações jurídicas do Estado moderno: o Estado Plurinacional boliviano
Authors: Botelho Martinho Martins , Winter Luís Alexandre Carta 
Published: March 2016

O objetivo do presente artigo é analisar as recentes modificações no ordenamento jurídico constitucional boliviano, no que tange à institucionalização do Estado Plurinacional, criado a partir do diálogo maior entre a democracia cultural, o direito e as instituições econômicas. Em 2009, fora aprovada a Constituição Política do Estado Plurinacional de Bolívia, depois de manifestação por meio de referendo. O legado da nova Constituição Política boliviana reside no desligamento com o antigo regime mais corporativista e voltado para a difusão de um ideal neoliberal socioeconômico. A compreensão da nova categoria constitucional poderá contribuir para o levantamento de elementos que possibilitem a compreensão de novas mutações constitucionais e intervenções jurídicas na sociedade do século XXI. O presente artigo busca refletir sobre a recente crise do Estado boliviano e na institucionalização do Estado Plurinacional como uma demanda social para a superação das ideias neoliberais.