bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioglass in Alveolar Bone Regeneration in Orthodontic Patients
Authors: El Shazley N. , Hamdy A. , El-Eneen H.A. , El Backly R.M. , Saad M.M. , Essam W. , Moussa H. , El Tantawi M. , Jain H. , Marei M.K. 
Published: August 2016

This study was designed as a split-mouth randomized controlled clinical trial to evaluate the effects of a novel bioactive glass scaffold—tailored amorphous multiporous (TAMP)—for the preservation of alveolar bone following tooth extraction in class II orthodontic patients. TAMP scaffolds were prepared and sterilized. Patients were screened for eligibility, and 6 patients accounting for 14 extraction sockets were included in this stage. Sockets were randomly allocated to either control (left empty) or test (grafted with TAMP scaffold particles). Follow-up was done after 1, 2, 4, 8, and 12 to 17 wk with digital periapical radiographs to evaluate changes in crestal bone height and bone mineral density (BMD), 3-dimensional volumetric analysis of impression casts, and histologic analysis of core biopsies. Furthermore, alveolar bone marrow mesenchymal stem cells were cultured from control and test sockets following biopsy retrieval to evaluate the ability of TAMP bioactive glass scaffolds to recruit host progenitor cells. Results showed that sockets grafted with TAMP bioactive glass scaffolds better preserved height after 3 mo where mesially 57.1% of test cases showed preservation of socket height, compared with 28.6% of control cases. Distally, this was 42.9% of test cases versus none of the control cases. Regarding BMD, the test sides had higher BMD in all 3 sections of the socket, with the greatest reduction in BMD found in the coronal third. Results were not statistically significant. Histologically, sockets grafted with TAMP bioactive glass scaffolds showed a distinct pattern of bone healing characterized by vertical trabeculae and large vascularized marrow spaces with sockets showing corticalization. Volumetric analysis showed a better preservation of socket contour with TAMP bioactive glass scaffolds. TAMP bioactive glass scaffolds appeared to enhance the recruitment of stem cells from the grafted sockets. In conclusion, TAMP scaffolds appear to better preserve alveolar bone following extraction and allow for a more active bone modeling and remodeling process( ClinicalTrials.gov identifier:NCT01878084). Knowledge Transfer statement: The results of this study set the stage for the recommended use of novel biomimetic scaffolds, such as the tailored amorphous multiporous bioactive glass for preservation of the socket following extraction. This can be valuable for patients and clinicians alike when deciding on long-term prosthetic alternatives that not only result in immediate bone preservation but will accommodate the dynamic nature of bone.
Comparison of survival between radiation therapy and trans-oral laser microsurgery for early glottic cancer patients; a retrospective cohort study
Authors: De Santis R. J. , Poon I. , Lee J. , Karam I. , Enepekides D. J. , Higgins K. M. 
Published: August 2016

Background The literature reports various treatment methodologies, such as trans-oral laser microsurgery, radiation therapy, total/partial laryngectomies, and concurrent radiation chemotherapy for patients with early larynx cancer. However, at the forefront of early glottis treatment is trans-oral laser microsurgery and radiation therapy, likely due to better functional and survival outcomes. Here we conduct the largest Canadian head-to-head comparison of consecutive patients treated with either radiation therapy or trans-oral laser microsurgery. Additionally, we compare these two treatments and their 5-year survival rates post treatment to add to the existing literature. Methods Charts of patients who were diagnosed with early glottic cancer between 2006 and 2013 were reviewed. Seventy-five patients were identified, and split into 2 groups based on their primary treatment, trans-oral laser microsurgery and radiation therapy. Kaplan–Meier survival curves, life-tables, and the log-rank statistic were reported to determine if there was a difference between the two treatment groups and their disease-specific survival, disease-free survival, and total laryngectomy-free survival. Additionally, each different survival analysis was stratified by potential confounding variables, to help conclude which treatment is more efficacious in this population. Results The 5-year disease-specific survival rate is 93.3 % σ = 0.063 and 90.8 % σ = 0.056 for patients treated with trans-oral laser microsurgery and radiation therapy, respectively ( χ2 < 0.001, p = 0.983). The disease free survival rate is 60.0 % (σ =0.121) for patients treated with trans-oral laser microsurgery, and 67.2 % (σ = 0.074) for those who received RT ( χ2 = 0.19, p = 0.663). Additionally, the total laryngectomy-free survival rate is 84.1 % (σ = 0.1) and 79.1 % (σ = 0.072) for patients’ early glottic cancer treated by trans-oral laser microsurgery and radiation therapy, respectively ( χ2 = 0.235, p = 0.628). Chi-square analysis of age-group versus treatment group ( χ2 = 6.455, p = 0.04) and T-stage versus treatment group ( χ2 = 11.3, p = 0.001) revealed a statistically significant relationship, suggesting survival analysis should be stratified by these variables. However, after stratification, there was no statistically significant difference between the trans-oral laser microsurgery and radiation therapy groups in any of the survival analyses. Conclusion No difference was demonstrated in the 5-year disease-specific survival, disease-free survival, and total laryngectomy-free survival, between the RT and TLM treatment groups. Additionally, both groups showed similar 5-year survival after stratifying by confounding variables.
Draft genome sequence of Mycobacterium rufum JS14T, a polycyclic-aromatic-hydrocarbon-degrading bacterium from petroleum-contaminated soil in Hawaii
Authors: Kwak Yunyoung , Li Qing X. , Shin Jae-Ho 
Published: August 2016

AbstractMycobacterium rufum JS14T (=ATCC BAA-1377T, CIP 109273T, JCM 16372T, DSM 45406T), a type strain of the species Mycobacterium rufum sp. . belonging to the family Mycobacteriaceae, was isolated from polycyclic aromatic hydrocarbon (PAH)-contaminated soil in Hilo (HI, USA) because it harbors the capability of degrading PAH. Here, we describe the first genome sequence of strain JS14T, with brief phenotypic characteristics. The genome is composed of 6,176,413 bp with 69.25 % G + C content and contains 5810 protein-coding genes with 54 RNA genes. The genome information on M. rufum JS14T will provide a better understanding of the complexity of bacterial catabolic pathways for degradation of specific chemicals.
Lymph Node Count From Neck Dissection Predicts Mortality in Head and Neck Cancer
Authors: Divi Vasu , Chen Michelle M. , Nussenbaum Brian , Rhoads Kim F. , Sirjani Davud B. , Holsinger F. Christopher , Shah Jennifer L. , Hara Wendy 
Published: August 2016

Purpose Multiple smaller studies have demonstrated an association between overall survival and lymph node (LN) count from neck dissection in patients with head and neck cancer. This is a large cohort study to examine these associations by using a national cancer database. Patients and Methods The National Cancer Database was used to identify patients who underwent upfront nodal dissection for mucosal head and neck squamous cell carcinoma between 2004 and 2013. Patients were stratified by LN count into those with < 18 nodes and those with ≥ 18 nodes on the basis of prior work. A multivariable Cox proportional hazards regression model was constructed to predict hazard of mortality. Stratified models predicted hazard of mortality both for patients who were both node negative and node positive. Results There were 45,113 patients with ≥ 18 LNs and 18,865 patients with < 18 LNs examined. The < 18 LN group, compared with the ≥ 18 LN group, had more favorable tumor characteristics, with a lower proportion of T3 and T4 lesions (27.9% v 39.8%), fewer patients with positive nodes (46.6% v 60.5%), and lower rates of extracapsular extension (9.3% v 15.1%). Risk-adjusted Cox models predicting hazard of mortality by LN count showed an 18% increased hazard of death for patients with < 18 nodes examined (hazard ratio [HR] 1.18; 95% CI, 1.13 to 1.22). When stratified by clinical nodal stage, there was an increased hazard of death in both groups (node negative: HR, 1.24; 95% CI, 1.17 to 1.32; node positive: HR, 1.12; 95% CI, 1.05 to 1.19). Conclusion The results of our study demonstrate a significant overall survival advantage in both patients who are clinically node negative and node positive when ≥ 18 LNs are examined after neck dissection, which suggests that LN count is a potential quality metric for neck dissection.
Drosophila's contribution to stem cell research
Authors: Singh Gyanesh 
Published: August 2016

The discovery ofDrosophilastem cells with striking similarities to mammalian stem cells has brought new hope for stem cell research. Recent developments inDrosophilastem cell research is bringing wider opportunities for contemporary stem cell biologists. In this regard,Drosophilagerm cells are becoming a popular model of stem cell research. In several cases, genes that controlledDrosophilastem cells were later discovered to have functional homologs in mammalian stem cells. Like mammals,Drosophilagermline stem cells (GSCs) are controlled by both intrinsic as well as external signals. Inside theDrosophilatestes, germline and somatic stem cells form a cluster of cells (the hub). Hub cells depend on JAK-STAT signaling, and, in absence of this signal, they do not self-renew. InDrosophila, significant changes occur within the stem cell niche that contributes to a decline in stem cell number over time. In case of agingDrosophila, somatic niche cells show reduced DE-cadherin and unpaired (Upd) proteins. Unpaired proteins are known to directly decrease stem cell number within the niches, and, overexpression ofupdwithin niche cells restored GSCs in older males also . Stem cells in the midgut ofDrosophilaare also very promising. Reduced Notch signaling was found to increase the number of midgut progenitor cells. On the other hand, activation of the Notch pathway decreased proliferation of these cells. Further research in this area should lead to the discovery of additional factors that regulate stem and progenitor cells inDrosophila.
Clinical Decision Support: a 25 Year Retrospective and a 25 Year Vision
Authors: Sittig D. F. , Wright A. , Middleton B. 
Published: August 2016

Summary
Objective: The objective of this review is to summarize the state of the art of clinical decision support (CDS) circa 1990, review progress in the 25 year interval from that time, and provide a vision of what CDS might look like 25 years hence, or circa 2040. Method: Informal review of the medical literature with iterative review and discussion among the authors to arrive at six axes (data, knowledge, inference, architecture and technology, implementation and integration, and users) to frame the review and discussion of selected barriers and facilitators to the effective use of CDS.Result: In each of the six axes, significant progress has been made. Key advances in structuring and encoding standardized data with an increased availability of data, development of knowledge bases for CDS, and improvement of capabilities to share knowledge artifacts, explosion of methods analyzing and inferring from clinical data, evolution of information technologies and architectures to facilitate the broad application of CDS, improvement of methods to implement CDS and integrate CDS into the clinical workflow, and increasing sophistication of the end-user, all have played a role in improving the effective use of CDS in healthcare delivery.
Conclusion: CDS has evolved dramatically over the past 25 years and will likely evolve just as dramatically or more so over the next 25 years. Increasingly, the clinical encounter between a clinician and a patient will be supported by a wide variety of cognitive aides to support diagnosis, treatment, care-coordination, surveillance and prevention, and health maintenance or wellness.
LA CENTRALITÉ LINGUISTIQUE DU FRANÇAIS DANS L’AFFICHAGE PUBLICITAIRE À MÉDÉA EN ALGÉRIE
Authors: HAMIDI Djamel 
Published: August 2016

<p><strong>RÉSUMÉ. </strong>Ce travail s’attache à approcher l’affichage publicitaire de point de vue sociolinguistique. Plus précisément, Il s’agit de voir les langues en présence dans l’espace urbain de Médéa. Pour ce faire, sur le plan théorique, nous avons inscrit notre objet d’étude dans le champ de la sociolinguistique urbaine, discipline qui questionne les pratiques sociolangagières dans leur complexité. Sur le plan méthodologique, nous nous appuyons sur un corpus constitué d’affiches publicitaires. Par le biais de ce corpus, nous focalisons notre attention, d’abord, sur la distribution des langues en contexte urbain ; puis, nous nous intéressons à la place de la langue française dans le paysage graphique urbain. Notre intérêt est donc de vérifier le poids des langues affichées dans la ville de Médéa.</p><p><strong> </strong></p><p><strong>Mots-clés : </strong><em>appropriation, langue, sociolinguistique</em><em>.</em></p><p><em><br /></em></p><p><strong>ABSTRACT. </strong>This work deals with the urban publicity boards from a sociolinguistic point of view. Mainly, it does deal with the languages presented in urban places of Médéa town. For that, theoretically, we have chosen to subscribe our object of study under the urban sociolinguistic field. This later studies sociolinguistic practices with their various complexities. From a methodological side, we have chosen a corpus consists of billboards. Using that corpus, we have focused first on the distribution of the languages on urban spaces, and after that, we have dealt with the place of French in this urban area. So, our objective is to know the value of all the languages in the city of médéa.</p><p><strong> </strong></p><p><strong>Keywords: </strong><em>appropriation<strong>, </strong>language, sociolinguistic.</em><strong></strong></p><p><em><br /></em></p>
RÉÉCRITURE ET APPROPRIATION DES TECHNIQUES RÉDACTIONNELLES DES ÉCRITS PROFESSIONNELS
Authors: KOAMA Clément 
Published: August 2016

<p><strong>RÉSUMÉ.</strong><strong> </strong>Cet article présente les résultats d’analyse d’une activité de réécriture en contexte universitaire. Au regard de ses préoccupations préprofessionnelles, le français sur objectifs universitaires accorde une grande importance à l’apprentissage de la rédaction des écrits professionnels. Toutefois, la bonne maîtrise de ces écrits est tributaire de la qualité des activités d’apprentissage proposées. La recherche de cette qualité oriente sans cesse vers l’exploration de nouvelles pistes. L’activité dont les résultats sont ici exposés mesure la plus-value de la réécriture en termes d’appropriation des techniques rédactionnelles du rapport, à partir de productions réécrites de manière collaborative.</p><p> </p><p><strong>Mots-clés:</strong> <em>apprentissage, didactique de l’écrit, rédaction professionnelle, réécriture.</em></p><p><em><br /></em></p><p><strong>ABSTRACT. </strong>This article presents the results of analysis of a university context rewriting activity. In relation to its pre-vocational concerns, French for academic purposes attaches great importance to learning the writing of professional writing. However, tight control of these writings is dependent on the quality of the proposed learning activities. The research of this quality oriented continually towards exploring new avenues. The activity whose results are here exposed measure the added value of rewriting in terms of ownership drafting the report techniques, from productions rewritten collaboratively.</p><p> </p><p><strong>Keywords:</strong><strong> </strong><em>Learning, teaching of writing, professional writing, rewriting.</em></p><p><em><br /></em></p>
Time-averaging e suas implicações para o registro fóssil marinho
Authors: Ritter Matias do Nascimento , Erthal Fernando 
Published: August 2016

A Tafonomia é uma área da Paleontologia que estuda como a informação biológica é alterada na rota teórica vivo-mortofóssil. Esta ciência tem se tornado cada vez mais quantitativa e se utilizado de estudos em ambientes modernos para generalizar os efeitos ao registro fóssil. Aqui é apresentada uma extensa revisão sobre o processo tafonômico denominado time-averaging, no qualfósseis não contemporâneos são encontrados em uma mesma camada fóssil, com base principalmente em invertebrados marinhos (moluscos). Além dos efeitos ao registro fóssil, são apresentadas as principais variáveis que atuam na formação do registro fóssil em um ambiente marinho de margem passiva.
A modelação aplicada à temática dos riscos naturais: O caso concreto de instituições de ensino superior em Portugal
Authors: Moutinho Sara Batista Gomes , Moura Rui Miguel Marques , Vasconcelos Clara Maria da Silva 
Published: August 2016

O recurso à modelação como metodologia de ensino é relevante no processo de recriação e simulação de fenómenos naturais, nomeadamente fenómenos geológicos e ambientais. Pretendendo-se verificar se o recurso à modelação é uma metodologia significativa no sucesso da aprendizagem dos estudantes de riscos naturais do ensino superior português, foram analisadas as fichas das unidades curriculares que abordam temáticas de riscos naturais nas universidades públicas portuguesas, tendo-se optado por selecionar apenas unidades curriculares do primeiro ciclo de estudos – licenciatura. No total foram analisadas, com recurso a uma grade de análise, oito fichas de unidades curriculares, ministradas em sete universidades públicas portuguesas. Asevidências encontradas indicam que nenhum dos documentos em análise contempla a utilização da modelação como metodologia de ensino de temáticas de riscos naturais, predominando um ensino essencialmente tradicional, sobressaindo a necessidade de intervenção ao nível das metodologias de ensino valorizando-se a manipulação e a exploração de modelos no ensino superior.
Políticas de Gênero e Desenvolvimento em Cabo Verde
Authors: Moassab Andréia , Vieira Miriam Steffen 
Published: August 2016

Desde a perspectiva de interseccionalidades como a relação entre distintos eixos de poder, este artigo apresenta uma análisesobre gênero e desenvolvimento nas áreas protegidas de CaboVerde. Focalizaremos a perspectiva de mulheres moradoras emtrês áreas protegidas – o Parque Natural de Serra Malagueta, oParque Natural do Fogo e o Parque Natural de Monte Gordo – emrelação às ações governamentais e não-governamentais visandoo“empoderamento” das mulheres. Para tanto, a análise estáamparada em trabalho de campo desenvolvido no período entreoutubro e novembro de 2010 e na realização de entrevistas comdiferentes intervenientes nas políticas de desenvolvimento e populações alvo. Foram analisadas as formações e microcréditosoferecidos nos Parques.
Interseccionalidades nas Quadrilhas Juninas em Aracaju/SE: Gênero, Geração e Sexualidades
Authors: Araújo Liana Matos 
Published: August 2016

O presente artigo é um estudo sobre as temáticas do gêneroe da geração que se tornaram pontos diacríticos durante umapesquisa de campo junto aos quadrilheiros de Aracaju/SE. Paraisso, toma-se a insterseccionalidade como a forma de articulartemas aparentemente distintos, porém relacionáveis, entre osmembros da instituição quadrilha junina. Pensar de forma interseccional possibilitará perceber como essas categorias estão interligadas e imbricadas nas práticas e sociabilidades das juventudes da Quadrilha Junina Apaga Fogueira. Desta maneira,a ideia é não fragmentar e nem hierarquizar uma categoria ou outra, mas entender como se dão as relações sociais entre elas mediante a transfiguração de alguns membros do sexo masculino vestidos com os trajes destinados ao sexo feminino tanto durante os ensaios quanto nas apresentações.
Well-Being Assessment of Youth in Urban Marginalized Community
Authors: Othman Saberi , Iskandar Mohd Mohni , Mohamed Nur Ikhwan 
Published: August 2016

This paper examines the well-being of eight domains of youth in the marginalized urban community. Study area was at Low Cost Housing Project of Lembah Pantai, Kuala Lumpur. Four hundred of youth age between 15 – 25 years old has been selected by stratified sampling. The average of well-being score is intermediate for the whole sample. However, the male score is slightly higher compared to female. Moral values show the highest score whilst participation in the community shows the lowest score for both male and female. As a conclusion, there is intermediate score of well-being of youth in the urban marginalized community.© 2016.The Authors. Published for AMER ABRA by e-International Publishing House, Ltd., UK. Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies, Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.Keywords: Well-being; marginalized; community; youth
LIMITS ON FAST RADIO BURSTS FROM FOUR YEARS OF THE V-FASTR EXPERIMENT
Authors: Burke-Spolaor S. , Trott Cathryn M. , Brisken Walter F. , Deller Adam T. , Majid Walid A. , Palaniswamy Divya , Thompson David R. , Tingay Steven J. , Wagstaff Kiri L. , Wayth Randall B. 
Published: August 2016

ABSTRACT
The V-FASTR experiment on the Very Long Baseline Array was designed to detect dispersed pulses of milliseconds in duration, such as fast radio bursts (FRBs). We use all V-FASTR data through 2015 February to report V-FASTR’s upper limits on the rates of FRBs, and compare these with rederived rates from Parkes FRB detection experiments. V-FASTR’s operation at

allows direct comparison with the 20 cm Parkes rate, and we derive a power-law limit of

(95% confidence limit) on the index of FRB source counts,

. Using the previously measured FRB rate and the unprecedented amount of survey time spent searching for FRBs at a large range of wavelengths (

cm), we also place frequency-dependent limits on the spectral distribution of FRBs. The most constraining frequencies place two-point spectral index limits of

and

, where fluence

if we assume that the burst rate reported by Champion et al. of

is accurate (for bursts of ∼3 ms duration). This upper limit on α suggests that if FRBs are extragalactic but noncosmological, on average they are not experiencing excessive free–free absorption due to a medium with high optical depth (assuming temperature ∼8000 K), which excessively inverts their low-frequency spectrum. This in turn implies that the dispersion of FRBs arises in either or both of the intergalactic medium or the host galaxy, rather than from the source itself.