bluuebunny/crossref_metadata_2025_split huggingface dataset:
An audit to assess the clinical use of blood and blood components at a tertiary care hospital
Authors: Yadav Anurag , Yadav Anmol Manaswini , Sirigere Muruga , Nandakumar LG  
Published: October 2024

An understanding of trends in blood and its product usage profile and current usage can help predict future trends in demand and help to put efforts to reduce use in particular areas. Present study aimed to assess the use of blood and blood components issued by blood bank and indication for selection of specific blood products. The present cross sectional observational time bound study was conducted at Father Muller Medical College & Hospital, which included all the patients to whom the whole or blood component are issued from blood between Jan 2016 to Jan 2020. All the units of blood and blood components issued to outside hospitals and institutions were excluded. A total of 20000 components were dispatched to 5002 patients request for the blood components from the blood bank, 2968 were males and 2032 were female patients (male to female ratio of 1.46:1). Highest request for blood components for transfusion was received from Medicine department and allied with 6063 units, followed with various Intensive care units (4477 units), oncology department (5729 units), OBG (1841 units), orthopaedics (1248 units) and surgery (453 units). The most common diagnosis for patients requiring blood components was haematological causes or Bleeding followed by elective surgery. Auditing the use of blood, its components and indications for their use by the various departments of the hospital has helped to finding the trend of number of blood.
La concurrencia de acreedores sobre bienes muebles inscribibles: análisis de los criterios de preferencia establecidos por el artículo 1136 del Código Civil y propuesta de reforma legislativa
Authors: Rubio Alcántara David , Ruiz Coral Maria Paula 
Published: October 2024

El actual régimen de concurrencia de acreedores de bienes muebles inscribibles ha sido objeto de numerosas críticas y comentarios. Por ello, el presente artículo examinará el tratamiento que ha recibido este régimen por la legislación aplicable y la jurisprudencia actual, así como su relación con los sistemas de transferencia de propiedad y los signos de cognoscibilidad de los derechos.Los autores se proponen identificar las soluciones que ofrece el artículo 1136 del Código Civil ante este supuesto para preguntarse e intentar responder cuál sería la regulación más acorde. Para ello, se empleará la doctrina, jurisprudencia y propuestas de reforma existentes.
La fianza como contrato y como carta: ¿dos caras de la misma moneda?
Authors: Peña Villanueva Álvaro 
Published: October 2024

La fianza es una figura jurídica que permite mayor seguridad en las transacciones y reduce los riesgos asociados a las inversiones y contrataciones. Con frecuencia, la imagen de la fianza como contrato y como carta converge; sin embargo, el autor muestra que ambas figuras poseen importantes matices y rasgos diferenciados. En esta línea, el presente trabajo aborda esta institución con un enfoque comparativo entre lo regulado por el Código Civil de 1936 y nuestro Código Civil vigente, mostrando las continuidades y modificaciones que ha sufrido la misma. Así, el autor establece que la regulación actual ofrece una mayor precisión conceptual y formalidad en la figura, haciendo más segura su aplicación.El autor también realiza un importante repaso de la aplicación de los términos de la fianza a través de un análisis de la reciente jurisprudencia. Este paso conlleva describir y analizar cuáles son los requisitos para participar/constituir una operación de este carácter.
Prevalence of chronic myocarditis in patients with atrial fibrillation according to the results of a single-center study
Authors: Archakov E. A. , Batalov R. E. , Khlynin M. S. , Dragunova M. A. , Sitkova E. S. , Eshmatov O. R. , Moskovskikh T. V. , Usenkov S. Yu. , Stepanov I. V. , Afanasyev S. A. , Popov S. V. 
Published: October 2024

Aim. To assess the incidence of chronic myocarditis in patients with atrial fibrillation.Material and methods. The study included 145 patients. The majority of patients were male — 118 (81.4%). The median age was 45 (38; 50) years. Most had paroxysmal AF — 60 (41.4%), slightly fewer had persistent AF — 55 (37.9%), 30 (20.7%) patients had long-term persistent AF. All patients underwent radiofrequency ablation of AF and endomyocardial biopsy (EMB) with subsequent histological and immunohistochemical studies (IHC). Morphological verification of myocarditis was performed in accordance with the Dallas criteria modified by the World Heart Federation.Results. Signs of chronic myocarditis were identified in 64 patients (44.1%). The median age of patients with myocarditis was 44 (36.5;49) years, without myocarditis — 46 (38;51) years. In men, myocarditis was detected in 50 cases (42%), in women — in 14 (51.9%). In paroxysmal AF, myocarditis was detected in 25 patients (41.7%), in persistent AF — in 23 (41.8%), and in long-term persistent AF — in 16 (53.3%). The groups with and without chronic myocarditis were comparable when compared based on the main echocardiographic parameters. Regression analysis did not show a significant influence of these factors on the probability of detecting chronic myocarditis in patients with AF. In patients under 30 years of age, there were no signs of inflammation without the presence of myocardial fibrosis, while the maximum stage of fibrosis occurred in patients from 31 to 40 years of age. The stage of fibrosis did not depend on gender. More often than others, a combination of enterovirus and herpes virus type 6 was detected in biopsy specimens. In patients over 51 years of age, biopsies generally did not express any virus on immunohistochemical studies.Conclusion. Chronic myocarditis in patients with AF was significantly more often detected in younger patients (up to 50 years inclusive), and was more common in women, as well as in the presence of a long-term persistent form of AF, regardless of gender. Detection of myocardial fibrosis signs is more typical for young patients with the maximum stage at the age of 31 to 40 years.
Nephroprotective and anticoagulant therapy in patients with atrial fibrillation and chronic kidney disease: real-world data
Authors: Listratov A. I. , Ivanov I. I. , Ziskina N. K. , Efimenko V. V. , Zhavoronkova A. V. , Milyakova E. S. , Kudrjavtseva A. A. , Napalkov D. A. , Sokolova A. A. 
Published: October 2024

Aim. To assess the compliance of nephroprotective and anticoagulant therapy in patients with atrial fibrillation (AF) and chronic kidney disease (CKD) with modern clinical guidelines.Material and methods. The study included patients with CKD in combination with AF and in sinus rhythm. Clinical characteristics were retrospectively assessed, as were the use of renin-angiotensin system inhibitors (RASi), statins, sodium-glucose transporter type 2 inhibitors (SGLT-2i) and oral anticoagulants (OAC).Results. A total of 464 patients (aged 66-80 years) were divided retrospectively in two subgroups — with and without AF. AF was detected in 210 (45.3%) patients. Patients from the subgroup with AF were significantly older (75 vs 72 years, p=0.001), more often had type 2 diabetes mellitus (T2DM) (28.6% vs 20.5%, p=0.042), coronary artery disease (CAD) (40.5% vs 30.7%, p=0.028) and chronic heart failure (CHF). (57.6% vs 22.8%, p<0.001). Mean estimated glomerular filtration rate (eGFR) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was lower (46 vs 51 ml/min/1.73 m2, p<0.001) in patients with AF compared with the group without AF. ACE inhibitors (ACEi) were prescribed in 127 cases (27.4%), angiotensin II receptor blockers (ARBs) — in 227 (49%), angiotensin receptor neprilysin inhibitor (ARNI) — 33 (7.1%), statins — 362 (78%), SGLT2i — 63 (13.6%), direct oral anticoagulants (DOACs) — 203 (43.8%) and warfarin — in 10 cases (2.2%). In those patients in whom SGLT2i was prescribed, eGFR according to the CKD-EPI equation was significantly lower (47 vs 49 ml/min/1.73 m2, p=0.043). In patients with T2DM, SGLT-2i-2 was prescribed in 33.9% of cases, in patients with chronic heart failure with reduced ejection fraction (CHFrEF) — in 68.4% of cases. In 196 patients with AF, DOACs were prescribed, in 10 cases — warfarin.Conclusion. Most patients with CKD receive nephroprotective therapy with RASi and statins according to current KDIGO guidelines. A significant proportion of patients with CHFrEF receive SGLT-2i, but only a third of patients with T2DM and CKD received SGLT-2i therapy.
Association of Systemic Immune Inflammation Index and System Inflammation Response Index with Cardiovascular Disease among prediabetes and diabetes
Authors: Sun Jiayu , Liu Min , Zhang Andong , Dong Yutong , Shi Mengmeng 
Published: October 2024

Abstract

We aimed to explore the association of the systemic immune inflammation (SII) index and system inflammation response index (SIRI) with CVD among prediabetes and diabetes. The cross-sectional study included 4534 participants with prediabetes and diabetes from the National Health and Nutrition Examination Survey (NHANES) 2015–2018. Multivariate logistic regression analysis was used to assess the association of SII and SIRI with CVD. Restricted cubic spline (RCS) model was used to examine the dose-response relationships between SII, SIRI, and CVD. Among 4,534 individuals with prediabetes and diabetes, the prevalence of CVD was 16.6%, with 19.4% in males and 14.0% in females. SII (OR: 1.27, 95%CI: 1.04–1.56) and SIRI (OR: 1.38, 95%CI: 1.09–1.76) were positively associated with CVD among prediabetes and diabetes. Among prediabetes, SIRI was positively associated with CVD (OR: 1.32, 95%CI: 1.03–1.70). Among diabetes, there was a similar finding that SIRI was positively associated with CVD (OR: 1.43, 95%CI: 1.04–1.96). The dose-responses relationship of SIRI with CVD was significantly nonlinear (P for nonlinear < 0.001). SIRI index may be an important biomarker in people with diabetes and prediabetes. Therefore, we recommended long-term monitoring of the SII index and SIRI in these vulnerable individuals.
Association between lactate and 28-day mortality in elderly patients with sepsis among different BMI groups:a cohort study
Authors: Zhang Haofeng , Tang Li , Zhang Jun 
Published: October 2024

Abstract

Introduction:The purpose of this study is to explore the association of baseline lactate level with 28-day mortality in elderly sepsis patients among different Body Mass Index (BMI) groups after ICU admission. Methods:In this retrospective cohort study,a total of 5699 patients with sepsis and age > 65 years were include from the Electronic Intensive Care Unit (eICU) Collaborative Research Database (eICU-CRD) from 208 distinct ICUs across the United States in 2014–2015.Lactate level and BMI at admission were obtained,and the outcome indicator was all-cause mortality within 28 days after ICU admission. A two-segment linear regression model was performed to verify the threshold effects of lactate on outcome and its differences among different BMI.Smooth curve fitting were also performed. Results:The ICU 28-day mortality of elderly sepsis patients in this study was 12.56%(n = 716). After adjustment for potential cofounders,for per 1mmol/L increase in lactate,the odds ratio(OR) of ICU 28-day mortality was 1.195(95%CI 1.136–1.257,P < 0.00001).Smooth fitting curves indicated a non-linear positive relationship between lactate and ICU 28-day mortality,with the turning point of lactate level was 5.5mmol/L.Below this threshold, each 1mmol/L increase in lactate increased the mortality risk by 37.5% (effect size 1.375, 95% CI 1.230–1.536, P < 0.0001).Results showed that the relationship between lactate and 28-day mortality exhibited different nonlinear patterns across BMI groups. Notably, in the group with BMI < 25, a significant increase in mortality risk was observed when lactate concentration was below 3.2mmol/L (1.630, 95% CI: 1.161, 2.287, P = 0.0047), while above this breakpoint, the increase in mortality risk was smaller (1.186, 95% CI: 1.024, 1.373, P = 0.0228). This pattern was also observed in the group with BMI ≥ 30, but the breakpoint effect was not significant in the group with BMI between 25 and 30. Conclusion: In critically ill patients with sepsis(age > 65 years) in ICU,a non linear positive relationship was discovered between lactate and ICU 28-day mortality.And the impact of lactate concentration on ICU 28-day mortality is not only related to lactate levels themselves but is also significantly influenced by BMI.This insight is crucial for clinicians in assessing patient mortality risk.
Bioinformatics Evidence of the Macrophage Inhibition In the Alleviation of Nonalcoholic Steatohepatitis Caused by Bariatric Surgery
Authors: Wang Ya Yun , ZHENG QIANWEN , Deng Shizhou , Chen Xiyu , Yang Yanling 
Published: October 2024

Abstract

The incidence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, and effective treatment is urgently needed. To understand the molecular mechanisms behind the effectiveness of bariatric surgery in treating NASH, we integrated single-cell and bulk RNA sequencing data to identify the role of liver macrophage polarization in alleviating NASH and screen possible drugs for treatment. Analysis revealed that bariatric surgery alleviates NASH by inhibiting liver M1 macrophage polarization with 12 differentially expressed M1 macrophage-related genes. Additionally, 56 potentially effective drugs were predicted for NASH treatment. These findings shed light on the effectiveness of bariatric surgery in treating NASH and offer potential drug candidates for further exploration.
Can an authoritarianism-compatible argument lead to greater support for immigration?
Authors: Buchanan Tessa , Young David J. , Ackland James , Renwick Alan , de-Wit Lee 
Published: October 2024

Abstract

Immigration has been a major point of contention for voters in 2024, a record year for elections, yet politicians rarely speak up in favour of it. Here we test with three studies (n=6,107) whether British attitudes towards immigration become more positive when participants are exposed to a short text written to be compatible with moderate levels of what political psychologists call ‘authoritarianism’. In the first study (n=2,004), participants report feeling that they share more values with a fictitious immigrant but this is not sufficient to change overall immigration attitudes. The second study (n=1,006) shows that when factual arguments and an emotional appeal are added to this text, this shifts attitudes towards immigration overall. The third study (n=3,097) confirms these results with a nationally and politically representative sample sourced from YouGov. These findings demonstrate that persuasion is possible on contentious issues like immigration, that immigration attitudes are not fixed, and that arguments in favour of immigration can be effective in the right context.
Association between Serum Milk Fat Globule-EGF Factor 8 and Prognosis in Patients with Heart Failure
Authors: Lu Feng , Hou Jie , Huang Xueyun , Zhang Shuguang , Zhou Lei 
Published: October 2024

Abstract

Objective: Investigating the relationship between serum milk fat globule-EGF factor 8 (MFGE8) and prognosis in patients with heart failure (HF).
Methods:This research conducted a prospective observational analysis on patients with HF at Huai’an TCM Hospital, which is affiliated with Nanjing University of Chinese Medicine between September 2021 and September 2022. The main focus was determined as combined result of being readmitted to the hospital for HF or all-cause death within a year. Various methods were utilized to evaluate the relationship between MFGE8 and prognosis, such as least absolute shrinkage and selection operator regression (LASSO), logistic regression, generalized additive model (GAM), multivariate adaptive regression splines (MARS), and random forest.
Results:A total of 153 patients were enrolled, and 44 patients had outcome events (28.76%). The MFGE8 at hospital release were significantly lower in patients with primary the main outcome (398 [258, 762] vs. 600 [36, 892], P = 0.002), as was the fold change of MFGE8 at discharge and admission (ΔMFGE8) (4.37 [-73.34, 69.1] vs. 58.6 [30.2, 88.2], P < 0.001). Four variables were chosen using by LASSO regression: hypertension, body mass index, MFGE8 at discharge, and ΔMFGE8. Multivariate logistic regression was implemented using the chosen variables. The results showed that MFGE8 at discharge (beta = -0.001, OR = 1.000, P = 0.039) and ΔMFGE8 (beta = -3.786, OR = 0.022, P = 0.003) were independently associated with primary outcome. The random forest model determined that the ΔMFGE8 is the variable with the highest level of significance (GINI coefficient: 10.64).
Conclusion: The presence of Serum MFGE8 is inversely associated with the likelihood of clinical outcome in HF patients, suggesting that it might be a valuable indicator of the prognosis for HF patients.
Impact of Testicular Cancer on Socio- Economic Health, Sexual Health and Fertility of Survivors – A Questionnaire based Survey
Authors: Khan M Raheel , Sheehan Patrice Kearney , Bazin Ashley , Leonard Christine , Aleem Umair , Farooq Abdul R , Corrigan Lynda , McDermott Ray 
Published: October 2024

Abstract

Purpose
Testicular cancer (TC) is diagnosed at a young age and carries a remarkably high cure rate even with advanced stage at diagnosis. Hence, there is a sizeable population living in the survivorship phase. Many studies have highlighted the plight of TC survivors as a result of late side effects of different therapeutic modalities used for treatment of TC. Although, a number of co-morbidities are known to cause chronic diseases and mortality in TC survivors, in this study we focus on the impact of TC on socio-economic health, sexual health and fertility.
Methods
We performed a questionnaire based survey on TC survivors in one of the cancer centres of Ireland. Questionnaires were designed to measure the impact on social, sexual and economic health on a five point Likert scale. Any effect on the fertility was investigated with questions regarding biological children before and after cancer with or without medical assistance.
Results
A total of 83 TC survivors participated in the study. Of all participants, 17% reported issues with fertility and the same proportion reported seeking medical help to conceive. The percentage of survivors who experienced fertility issues persisting for more than 1 year was 14%. Almost half of our respondents revealed some effect on their performance at work and personal finances. Around one third, had an impact on career choice, job security and relationship with their partner. Regarding sexual health, worst repercussions were noted on the sex drive and body image perception, where close to half of the respondents reported at least some deterioration. Ejaculation and erectile function was affected in 30% of the participants.
Conclusions
High cure rates in TC are coupled with long term side effects, consequently affecting the socio-economic and sexual health of survivors. A comprehensive and holistic survivorship program is needed to improve the quality of life and health of TC survivors.
Association between BMI and outcomes in critically ill patients: An analysis of the MIMIC-III database
Authors: Yu Wenbo , Jiang Weiwei , Yuan Jihong , Fan Tao , Xiao Huiyan , Sun Lizhu , Zhu Yan , Li Wenfang , Wu Shaoshuai 
Published: October 2024

Abstract

Background: Obesity is a significant public health challenge, yet the link between BMI and mortality in critical illness remains unclear.
Methods: This study analyzed 19,311 patients from the MIMIC-III database, categorized into underweight, healthy, overweight, and obese groups. Using Cox models and restricted cubic splines, we explored the complex relationship between BMI and mortality. Finally, multiple sensitivity analyses were performed to test the robustness of the results.
Results: The proportion of underweight patients (2.3%) was the lowest, while overweight (34.8%) and obese (34.5%) patients constituted a large proportion. Being underweight portended a greater risk, while being overweight or obese was associated with a lower risk of mortality, which is consistent with the sensitivity analysis. Moreover, we observed a typical L-shaped relationship between BMI and the risk of mortality with and without adjustment, with the lowest mortality occurring at approximately 32 kg/m². The overall pattern of the nonlinear association between BMI and mortality was similar for most subgroup analyses.
Conclusions: Underweight was associated with a greater risk of mortality, while obesity and overweight were both associated with a lower risk of mortality in critically ill patients. BMI had a typical L-shaped association with the risk of mortality.
A new combined reduction anatomical plate for the treatment of acetabular anterior column and posterior hemi-transverse fractures: a finite element analysis study
Authors: Chen Lin , Bao Chongshuai , Jun Ao , Wang Ansu 
Published: October 2024

Abstract

Background: Acetabularanterior column and posterior hemi-transverse fractures pose a significant challenge for orthopaedic surgeons. Traditional treatment methods are associated with high rates of post-operative complications and lengthy surgical procedures. To enhance treatment efficacy, this study developed a novel internal fixation device called the Combined Reduction Anatomical Plate (CRAP) and conducted a finite element analysis to compare its biomechanical properties to those of traditional internal fixation methods.
Methods: A standard finite element model of an anterior column and posterior hemi-transverse fracture of the acetabulum was established using finite element software. Subsequently, four different internal fixation devices were applied: CRAP, double-column locking plates (DLP), supra-pectineal quadrilateral anatomical plate (SQAP), and iliositus + anterior column plate (LACP). After determining the boundary conditions and material properties, the model was simulated in three different body positions (standing, sitting, and lying on the affected side) and subjected to vertical downward forces of 200 N, 400 N, and 600 N. Subsequently, the stress distribution and peak values among the four fixation methods were analyzed, and the maximum pelvic displacement and fracture fragment displacement were evaluated.
Results: In this study, the CRAP maximum stress on the steel plate and screws was 159.540 N, 160.540 N, 157.050 N, 177.330 N, 64.756 N, and 30.003 N, which was less than that of the SQAP and LACP and greater than that of the DLP. The maximum tangential micromotion of the CRAP was only 0.016 mm, and the maximum displacement of the pelvis was 0.855 mm. The results showed that the new type of plate developed and designed in this study exhibited a relatively uniform stress distribution and high stiffness, providing sufficient strength. However, the four groups showed no obvious difference in tangential fretting.
Conclusion: Compared with the other three fixation methods, the newly designed sectional anatomical reduction plate and screws showed a uniform stress distribution, greater rigidity, sufficient strength, and improved mechanical stability. The CRAP can therefore provide sufficient biomechanical stability and help fracture healing.