bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memory detection with concurrent behavioral, autonomic, and neuroimaging measures in a mock crime
Authors: Wang Chongxiang , Yi Xingyu , Li Hongrui , Ke Ni , Lei Zhili , Fu Genyue , Lin Xiaohong Allison 
Published: October 2024

AbstractConcealed information test (CIT) has been utilized for long to perform single measurements. The combination of multiple measures outperforms single measures because of the diverse cognitive processes they reflect and the reduction in random errors facilitated by multiple measures. To further explore the performance of the CIT with multiple measurements, 57 participants were recruited and randomly assigned into guilty and innocent groups. Subsequently, simultaneously recorded reaction time (RT), skin conductance responses (SCRs), heart rate (HR), and neuroimaging data were collected from functional near‐infrared spectroscopy (fNIRS) to detect participants' concealed information in a standard CIT. The results demonstrated that all indicators including RT (area under the curve (AUC) = 0.87), SCRs (AUC = 0.79), HR (AUC = 0.78), and fNIRS (channel 8, AUC = 0.85) could differentiate guilty and innocent groups. Importantly, the use of multiple indicators achieved higher detection efficiency (AUC = 0.96) compared to the use of any single indicator. These results illustrate the effectiveness and feasibility of integrating multiple indicators for concealed information detection in CIT.
Heavenly metrics, hyper‐Lagrangians and Joyce structures
Authors: Dunajski Maciej , Moy Timothy 
Published: October 2024

AbstractIn [Proc. Sympos. Pure Math., American Mathematical Society, Providence, RI, 2021, pp. 1–66], Bridgeland defined a geometric structure, named a Joyce structure, conjectured to exist on the space of stability conditions of a triangulated category. Given a non‐degeneracy assumption, a feature of this structure is a complex hyper‐Kähler metric with homothetic symmetry on the total space of the holomorphic tangent bundle. Generalising the isomonodromy calculation which leads to the Joyce structure in [Math. Ann. 385 (2023), 193–258], we obtain an explicit expression for a hyper‐Kähler metric with homothetic symmetry via construction of the isomonodromic flows of a Schrödinger equation with deformed polynomial oscillator potential of odd‐degree . The metric is defined on a total space of complex dimension and fibres over a ‐dimensional manifold which can be identified with the unfolding of the ‐singularity. The hyper‐Kähler structure is shown to be compatible with the natural symplectic structure on in the sense of admitting an affine symplectic fibration as defined in [Lett. Math. Phys. 111 (2021), 54]. Separately, using the additional conditions imposed by a Joyce structure, we consider reductions of Plebański's heavenly equations that govern the hyper‐Kähler condition. We introduce the notion of a projectable hyper‐Lagrangian foliation and show that in dimension four such a foliation of leads to a linearisation of the heavenly equation. The hyper‐Kähler metrics constructed here are shown to admit such a foliation.
Diophantine approximation by rational numbers of certain parity types
Authors: Kim Dong Han , Lee Seul Bee , Liao Lingmin 
Published: October 2024

AbstractFor a given irrational number, we consider the properties of best rational approximations of given parities. There are three different kinds of rational numbers according to the parity of the numerator and denominator, say odd/odd, even/odd, and odd/even rational numbers. We study algorithms to find best approximations by rational numbers of given parities and compare these algorithms with continued fraction expansions.
Pacific Ocean Windspeeds Prediction by Gaidai Multivariate Risks Evaluation Method, Utilizing Self-Deconvolution
Authors: Gaidai Oleg 
Published: October 2024

Abstract
The current study advances research on the consequences of global climate change by utilizing the novel Gaidai multivariate risks evaluation methodology to conduct spatiotemporal analysis of areal windspeeds. Multidimensional structural and environmental dynamic systems that have been either physically observed or numerically simulated over a representative time-lapse are particularly suitable for the Gaidai risks evaluation methodology. Current research also presents a novel non-parametric deconvolution extrapolation method. As this study has shown, given in situ environmental input, it is possible to accurately predict environmental system hazard risks, based even on a limited underlying dataset. Furthermore, because of their complex nonlinear cross-correlations between various environmental system-critical dimensions or components and large dimensionality, environmental dynamic systems are difficult to handle using traditional methods for evaluating risks. In the North Pacific, close to the Hawaiian Islands, NOAA buoys gathered raw in situ wind speed data, which has been utilized in the current study. Areal ocean wind speeds constitute quite a complex environmental dynamic system that is challenging to analyze because of its nonlinear, multidimensional, cross-correlated nature. Global warming had impacts on ocean windspeeds in the recent decade. Developing novel state-of-the-art environmental system risk evaluation methods is a principal component of modern offshore structural analysis in light of adverse weather. The advocated novel risk/hazard assessment approach may be used for resilient island cities design, especially those that are near ocean shore and hence exposed to extreme weather.
Late Quaternary slip rate of the strike-slip faults on the eastern margin of the Qaidam Basin on the Tibetan Plateau and its implication on regional strain partitioning
Authors: Bao Guodong , Ren Zhikun , Liu Jinrui , Ha Guanghao , Ji Haomin , Wang Lei 
Published: October 2024

Abstract
The spatial variation in slip rates of large-scale strike-slip faults provides crucial support for the conceptual models of continental collision. However, the reasons for the decrease in slip rate of the East Kunlun Fault at the eastern margin of the Qaidam Basin on the Tibetan Plateau are still unclear. At the eastern margin of the Qaidam Basin, we identified four active strike-slip faults—two NW-SE–orientated dextral (the Xiariha Fault and Yingdeerkang Fault) and two E-W–orientated sinistral (the Reshui-Taosituohe Fault and Taosituohenan Fault)—and determined their slip rates using uncrewed aerial vehicle-based topography and optically stimulated luminescence dating. For the Xiariha Fault, from north to south slip rates are 1.39 +0.51/−0.34 mm/yr, 1.19 +0.15/−0.14 mm/yr, and 0.9 +0.19/−0.16 mm/yr. The Yingdeerkang Fault slips at 0.66 +0.08/−0.07 mm/yr. The Reshui-Taosituohe Fault, from west to east, slips at 0.95 +0.22/−0.19 mm/yr and 1.20 +0.11/−0.09 mm/yr. The Taosituohenan Fault, west to east, slips at 0.62 +0.12/−0.12 mm/yr to 1.01 +0.21/−0.19 mm/yr and 1.21 +0.43/−0.25 mm/yr. We believe that the gradual decrease in slip rate of the East Kunlun Fault at the Tuosuo Lake segment toward the east is influenced by the activity of the four active strike-slip faults with a slip rate of ~1 mm/yr along the eastern margin of the Qaidam Basin and the Elashan Fault. The decrease in fault slip rate is not solely attributed to the diverse structural styles of the fault itself but also to the strain absorption by the development of differently oriented faults around its periphery.
Poor venous outflow is associated with hyperintense acute reperfusion marker on follow-up MRI in patients with acute ischemic stroke with a large vessel occlusion
Authors: Zamarud Aroosa , Yuen Nicole , Wouters Anke , Mlynash Michael , Hugdal Stephen M , Seners Pierre , Kesten Jamie , Yedavalli Vivek , Faizy Tobias D , Albers Gregory W , Lansberg Maarten G , Heit Jeremy J 
Published: October 2024

BackgroundHyperintense acute reperfusion marker (HARM) refers to delayed enhancement in the subarachnoid or subpial space on post-contrast fluid attenuated inversion recovery (FLAIR) images. HARM is a measure of blood–brain barrier breakdown, which has been correlated with poor outcomes in patients with acute ischemic stroke with large vessel occlusion (AIS-LVO). We hypothesized that unfavorable venous outflow (VO) would be correlated with HARM after thrombectomy treatment of AIS-LVO.ObjectiveTo determine whether poor VO is associated with HARM on follow-up MRI after stroke in patients with AIS-LVO.MethodsPatients with AIS-LVO from the prospective CRISP2 and DEFUSE2 studies with a baseline CT angiography (CTA) scan and a follow-up MRI with FLAIR sequence were screened for enrollment. VO was measured on the baseline CTA scan using the cortical venous opacification score (COVES). HARM was determined on FLAIR sequences at the follow-up MRI. The primary outcome was the occurrence of HARM between those with good VO (VO+; COVES 3–6) and bad VO (VO−; COVES 0–2).Results121 patients were included; 60.3% (n=73) had VO+ and 39.7% (n=48) had VO−. Patients with VO− had higher presentation National Institutes of Health Stroke Scale scores (18 (IQR 12–20) vs 12 (IQR 8–16) in VO+; P<0.001). Middle cerebral artery M1 segment occlusions were more common in VO− patients (65% vs 43% VO+; P=0.028). VO− patients also had a larger pre-treatment ischemic core (23 (4–44) mL vs 12 (3–22) mL in VO+; P=0.049) and Tmax >6 s volumes (105 (72–142) mL vs 66 (35–95) mL in VO+; P<0.001). VO− patients were more likely to develop HARM after thrombectomy (31% vs 10% in VO+; P=0.003). On multivariable regression analysis, VO− (OR=3.6 (95% CI 1.2 to 10.6); P=0.02) and the presence of any ICH (OR=3.6 (95% CI 1.2 to 10.5); P=0.02) were independently associated with the occurrence of HARM.ConclusionsIn patients with AIS-LVO, VO− correlated with HARM on post-thrombectomy MRI.
Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival Signaling in Head and Neck Squamous Cell Carcinoma
Authors: Morgan Ethan L. , Saleh Anthony D. , Cornelius Shaleeka , Carlson Sophie G. , Toni Tiffany , Cheng Hui , Jeon Jun , Viswanathan Ramya , Yang Xinping , Silvin Christopher , Clavijo Paul E. , Sowers Anastasia L. , Mitchell James B. , Ormanoglu Pinar , Lal Nag Madhu , Martin Scott E. , Chen Zhong , Van Waes Carter 
Published: October 2024

Abstract
Immune and radiation resistance of cancer cells to cytotoxicity mediated by TNFα is promoted by the transcription factor NF-κB in several cancers, including head and neck squamous cell carcinoma (HNSCC). Genomic alterations that converge on the TNFα/NF-κB signal axis were found in ∼40% of HNSCCs by The Cancer Genome Atlas. However, identification of therapeutic targets that contribute to aberrant TNFα/NF-κB activation and resistance has been challenging. Here, we conducted a functional RNAi screen to identify regulators of TNFα-induced NF-κB activation and cell viability, using parallel NF-κB β−lactamase reporter and cell viability assays in a HNSCC cell line which harbors expression and genomic alterations typically found in human papillomavirus–negative HNSCC. Besides multiple components of canonical TNFα/NF-κB signaling, we identified components of the WNT, NOTCH, and TGFβ pathways that we previously showed contribute to noncanonical activation of NF-κB. Unexpectedly, we also observed that multiple G2/M cell-cycle kinases [Aurora kinase A, polo-like kinase 1, WEE1, and threonine tyrosine kinase (TTK)], and structural kinetochore/microtubule components (NDC80 and NUF2), modulate TNFα-induced NF-κB activation and cell viability. Several of these targets inhibit TNF-induced nuclear translocation of RELA, consistent with prior reports linking NF-κB activation to G2/M kinases or microtubule assembly. Further investigation of an understudied mitotic kinase, TTK/monopolar spindle 1, shows that its inhibition or depletion attenuates TNFα-induced RELA nuclear translocation, promoting cell death, DNA damage, polyploidy, and mitotic catastrophe, leading to radiosensitization. Together, our RNAi screening identifies a critical linkage between the G2/M cell-cycle checkpoint/kinetochore components and NF-κB activity, as well as targets that can sensitize HNSCC cells to TNFα or radiation.

Significance:
Here, RNAi library screening reveals that multiple G2/M and kinetochore components, including TTK/monopolar spindle 1, modulate TNFα-induced NF-κB activation, cell survival, and genotoxicity, underscoring their potential importance as therapeutic targets in HNSCC.
Major Adverse Cardiovascular Events Following Coronary Artery Stenting by History of Hypertensive Disorder of Pregnancy
Authors: Gunnarsson Omar Sigurvin , Pihlsgård Mats , Handmark Moa , Sarno Giovanna , Gonçalves Isabel , Timpka Simon 
Published: October 2024

Background
A history of hypertensive disorders of pregnancy is associated with at least twice the risk of incident ischemic heart disease. Whether the long‐term outcome following treatment with coronary artery stenting is associated to the history of hypertensive disorders of pregnancy is unknown.

Methods and Results

We included 8364 women (age ≤65 years) undergoing first coronary artery stenting 2006 to 2022 following their first delivery in 1973 or later, linking nationwide data on percutaneous coronary intervention and delivery history. In total, 1122 women (13.4%) had a history of hypertensive disorders of pregnancy. The main outcome, a major adverse cardiovascular event, was defined as any incident myocardial infarction, ischemic heart disease, cardiac arrest, arrhythmias, angina pectoris, heart failure, cerebral infarction, or sudden death. During a median follow‐up time of 5 years, 258 women with a history of hypertensive disorders of pregnancy had a major adverse cardiovascular event, compared with 1465 women without a history of hypertensive disorders of pregnancy (23% versus 20.2%,
P
=0.028 for log‐rank test). Estimates adjusted for patient‐ and procedural characteristics in proportional hazards regression models suggested that the hazard rate increased only after 4–8 years of follow‐up (hazard ratio [HR], 1.36 [95% CI, 1.05–1.78]) and was primarily driven by women with history of gestational hypertension (HR, 2.15 [95% CI, 1.49–3.11]).

Conclusions
Women with a history of hypertensive disorders of pregnancy have an increased risk of a major adverse cardiovascular event following coronary artery stenting compared with other parous women. A history of hypertensive disorders of pregnancy warrants further attention in the secondary prevention setting of coronary artery disease.
A convenient and versatile culturomics platform to expand the human gut culturome of Lachnospiraceae and Oscillospiraceae
Authors: Plomp N. , Liu L. , Walters L. , Bus-Spoor C. , Khan M.T. , Sheridan P.O. , Veloo A.C.M. , Walker A.W. , Harmsen H.J.M. , Tsompanidou E. 
Published: October 2024

Abstract
The human gut microbiota is increasingly being recognised to play an important role in maintaining health. The families Lachnospiraceae and Oscillospiraceae in particular, are often reduced in disease states but are relatively poorly represented in culture collections. Cultured representatives are required to investigate the physiology and host interactions of gut microbes. Establishing cultured isolate collections can be laborious and expensive owing to the fastidious growth requirements of these organisms and the costs associated with taxonomic classification. This study proposes a culturomics platform combining a single basal culture medium with matrix-assisted laser adsorption/ionisation coupled to time-of-flight mass spectrometry (MALDI-TOF MS) for fast and reliable isolation and identification of hundreds of novel isolates. In this study, basal YCFA medium supplemented with either glucose, apple pectin, or porcine mucin was used to cultivate a total of 724 different isolates derived from only 11 different faecal samples from healthy volunteers, of which 389 isolates belonged to the Lachnospiraceae and Oscillospiraceae families. Moreover, 27 isolates could not be assigned to known species based on their 16S rRNA gene, 17 of which may even represent novel genera. To aid MALDI-TOF MS identification of gut bacteria, the commercial database was complemented with the MaldiGut database presented here, containing a collection of 132 different Main Spectrum Profiles, including the profiles of 125 Firmicutes species, 3 Bacteroidetes species, 3 Actinobacteria species, and one Verrucomicrobia species. The culturomics platform and MaldiGut database presented here will enable further expansion of the gut culturome, especially within the understudied Lachnospiraceae and Oscillospiraceae families.
Incidence and Outcomes of Pregnant Trauma Patients With Positive Urine Toxicology: A Southern California Multicenter Study
Authors: Clark Isabel , Nahmias Jeffry , Jebbia Mallory , Aryan Negaar , Lucas Alexa N. , Fierro Nicole , Dhillon Navpreet K. , Ley Eric J. , Smith Jennifer , Burruss Sigrid , Dahan Alden , Johnson Arianne , Ganske William , Biffl Walter L. , Bayat Dunya , Castelo Matthew , Wintz Diane , Schaffer Kathryn B. , Zheng Dennis J. , Tillou Areti , Coimbra Raul , Tuli Rahul , Santorelli Jarrett E. , Emigh Brent , Schellenberg Morgan , Inaba Kenji , Duncan Thomas K. , Diaz Graal , Tay-Lasso Erika , Zezoff Danielle C. , Grigorian Areg 
Published: October 2024

Background: The use of illicit substances during pregnancy has increased 4-fold in the past two decades, negatively impacting both mother and fetus. The rate and clinical outcomes of substance use in pregnant trauma patients (PTPs) are not well studied. We sought to evaluate clinical outcomes of PTPs with positive urine toxicology, hypothesizing a higher rate of in-hospital maternal complications for PTPs with a positive urine toxicology ((+)Utox) compared to those testing negative ((−)Utox). Methods: PTPs (≥18 years old) were included in this multicenter retrospective study between 2016 and 2021. We included patients with known urine toxicology results and compared (+)Utox vs (−)Utox PTPs. Results: From 852 PTPs, 84 (9.8%) had a (+)Utox with the most common illicit substance being THC (57%) followed by methamphetamine (44%). (+)Utox PTPs had higher rates of blunt head injury (9.5% vs 4.2%, P = .028), extremity injury (14.3% vs 6.5%, P = .009), domestic violence (21.4% vs 5.9%, P < .001), suicide attempt (3.6% vs 0.3%, P < .001), and uterine contractions (46% vs 23.5%, P < .001). Abnormal fetal heart tracing, premature rupture of membranes and placental injury were similar between groups (all P > .05). The rate of maternal complications was similar in both groups (all P > .05). Conclusion: In this study, the rate of (+)Utox in PTPs was 9.8%. The (+)Utox group had similar rates of maternal complications but more commonly experienced uterine contractions which may be related to the physiology of drugs such as methamphetamines. PTPs with (+)Utox also more commonly were victims of domestic violence and suicide attempt, which merits further prevention research efforts.
Nonlinear model predictive dynamic positioning of a remotely operated vehicle with wave disturbance preview
Authors: Walker Kyle L. , Jordan Laura-Beth , Giorgio-Serchi Francesco 
Published: October 2024

Exploiting preview information of disturbances within robot control is an effective method of handling state perturbations. For underwater vehicles operating in wave-dominated environments, disturbances significantly influence vehicle response and pose a threat to operational safety. In consideration of this, a complete end-to-end control architecture is developed in this work for disturbance rejection during station keeping tasks under wave perturbations, encompassing a nonlinear model predictive controller (NMPC) combined with a deterministic sea wave predictor (DSWP). The wave predictor exploits a continuous measurement of the wave elevation at a location upstream of the vehicle to form a forecast of the temporal evolution of the wave elevation at the vehicle location. The predicted wave parameters are then used to estimate the impending wave-induced hydrodynamic loading, enabling explicit consideration of accurate short-term disturbance forecasts within the controller, ensuring this preview is incorporated in the optimised control sequence. Experimental testing confirms the validity of the wave predictor, producing RMSE as low as 0.017 m. The proposed strategy is then simulated under various wave conditions, optimising control actions inclusive of the preview information. The NMPC outperforms a similar disturbance mitigating feed-forward controller, with average improvements of up to 52% and is found to perform best even with noisy, lower accuracy wave predictions, as well as with communication time delays, providing a high degree of robustness. This demonstrates the potential of the proposed control framework to effectively tackle disturbance mitigation of underwater vehicles subject to large magnitude wave disturbances, expanding the operational envelop of autonomous systems towards forbidding ocean environments.
Health Insurance for Universal Health  Coverage in India
Authors: Datta Shreyasee , Bagli Supravat 
Published: October 2024

The role of health insurance in expanding Universal Health Coverage is to ease the access to healthcare services and reduce the risk of unexpected health expenditure burden. In order to examine this role, this article assesses the contribution of enrolment in health insurance on the utilisation of healthcare services and out-of-pocket expenditure for working-age Indians. Investigation into these two issues, addressing the self-selection/endogeneity problem in buying health insurance, is uncommon in the literature. Against this end, the probability of utilising healthcare services and the incurred out-of-pocket expenditure has been estimated using National Sample Survey (2017–2018) data in India. Empirical findings reveal evidence of endogeneity in health insurance enrolment for hospitalisation, which indicates the presence of self-selection in health insurance enrolment. Addressing the endogeneity problem, this study has found a higher probability of utilising hospitalisation and lower out-of-pocket expenditure among insured individuals than others. Socio-economic and demographic variables like household income, education, gender, religion and state of residence are important to determine the utilisation of healthcare facilities. On the other hand, while out-of-pocket expenditure incurred for hospitalisation significantly varies with age, gender, social caste, religion, working status, state of residence, nature of ailment and type of hospital, household income and health status have no significant effect on out-of-pocket expenditure. Poor people are less likely to be hospitalised, and compared to males, females have a higher probability of utilising healthcare services at their reproductive age. State-level health policies and health insurance schemes play a crucial role in determining health insurance participation and utilisation of health services. JEL: C13, C21, C25, I10, I11, I13, I14, I18
Economic Openness and the Behaviour of Great Ratios in G20 Countries
Authors: Arjun  , Mishra Bibhuti Ranjan , Aneja Ranjan 
Published: October 2024

Most of the macroeconomic models suggest that great ratios of economics should be stable in the long term. Keeping the theoretical consequences in mind, the present study investigates the order of integration of two great ratios, viz. consumption–output and investment–output ratios. The study employs both mean shift and trend shift unit root tests with a structural break to examine the stationarity property of great ratios. This article attempts to analyse the relationship between economic openness and the behaviour of great ratios. Results of the study indicate a balanced growth path for 10 out of 18 G20 countries considered in our analysis. Findings show that countries that have a deficit trade balance with surplus foreign direct investment are more likely to demonstrate a balanced growth path. The multivariate analysis shows evidence in support of the balanced growth hypothesis in 13 of the 18 G20 countries. Of the 18 countries analysed, 8 internationally open and 6 financially open countries provide support for the balanced growth path. JEL: C20, E20, O50