bluuebunny/crossref_metadata_2025_split huggingface dataset:
Balancing Privacy and Precision: Evaluating Meta-Analysis for National Health Data Integration in Canada
Authors: Harmon Megan , Black Jason , Li Na , Sajobi Tolulope , Holodinsky Jessalyn , Williamson Tyler 
Published: September 2024

BackgroundIn Canada, legislative restrictions exist for the disclosure and transfer of patient data across provincial boundaries. Often, meta-analysis techniques are employed to pool province-specific results to enable national results while maintaining compliance with privacy legislation. However, the effectiveness of this technique remains unexamined using electronic data. To evaluate its performance, we compare results obtained through meta-analysis with those from a fully pooled model.
MethodsUsing chronic kidney disease as a case study, this retrospective cohort study simulates the meta-analysis method to evaluate its performance using real data. We analyze data from the Canadian Primary Care Sentinel Surveillance Network (CPCSSN), a nationwide database of electronic medical records. We meta-analyze provincial logistic regression models to predict nephropathy over a 5-year period at a national level. Estimates are compared to a fully pooled national model.
ResultsAnalyses are currently ongoing. We expect the meta-analysis technique to produce similar estimates compared to the fully pooled model. However, we expect certain differences as meta-analysis techniques are insensitive to heterogeneity within provinces that impact the precision of estimates. Observed differences will help to inform future work where we will examine a potential new methodology to analyze health information without sharing patient data.
ConclusionsBased on our results, we will reveal strengths and limitations of the meta-analysis technique for interprovincial analyses. Limitations of the meta-analysis technique may underscore the need for further exploration into alternative methodologies that can effectively analyze health information without compromising patient privacy to facilitate better healthcare decision-making and policy development in Canada.
Center for Advanced Studies in Child Welfare, University of Minnesota
Authors: Johnson Sydney , Piescher Kristine , Lindstrom Rhea Leah , Stetzel Amy 
Published: September 2024

Objective and ApproachPrior research has found that experiences of homelessness are associated with an increased likelihood of child protection involvement, and vice-versa. However, it is not clear how involvement with the child welfare system may impact family housing stability during and after their involvement. The objective of this study was to more deeply understand the housing stability of families involved with child welfare over time.
To examine this issue, we linked administrative data from Minnesota’s Homelessness Management Information System with social services data from the Department of Human Services (e.g., receipt of food support, childcare or housing assistance, child welfare), for families involved with child welfare in Minnesota between 2019 and 2021.
ResultsApproximately a quarter of child welfare-involved families experienced homelessness during their involvement with the child welfare system. Rates of homelessness were similarly high in the two years prior to and following child welfare involvement. Although a large proportion of families experienced homelessness before and during their child welfare involvement, we saw no increase in the proportion of families receiving housing support after their involvement in the system.
Conclusions and ImplicationsOur findings indicate that involvement with the child welfare system and the resources provided through this involvement do not have a significant impact on family’s experiences of homelessness. This suggests the need for closer collaboration between the child welfare system and housing services to identify more effective solutions for housing instability among families within the child welfare system.
Assessing Hospital Data Quality: Application of a Data Quality Tool in 15 Countries
Authors: Sandhu Namneet , Whittle Sarah , Varela Lucia Otero , Eastwood Cathy A , Southern Danielle A , Quan Hude 
Published: September 2024

IntroductionGlobally, differences in coding practices and guidelines lead to variations in hospital-administrative data. Studies on patient safety found that better hospital-data quality is associated with higher rates of patient safety events. This study outlines our process of creating a standardized tool for countries to assess their hospital-administrative data quality.
ApproachWe developed 24 indicators across five different dimensions through a Delphi-consensus method. To test applicability of these indicators, we approached representatives from 50 countries with an online survey comprised of qualitative and quantitative questions. Characteristics of each country and indicator scores were noted. A data quality overall score, out of 20, was calculated for each country based on survey responses. The score was classified into 3 data quality categories: high (≥18), moderate (13-17.9), and low (<13).
ResultsOf the 50 countries invited, 17 responded. Surveys from two countries were excluded due to insufficient data. Country responses (n=15) were evaluated and scored by dimension. The data quality indicators showed positive face validity and were applicable for most countries providing comparative information for development of the tool with good discrimination. Canada, USA, New Zealand, UK, and Spain were among the countries with an overall high data quality score (≥18). Most countries scored high in 3 out of 5 dimensions of data quality. A few countries scored 0 out of 4 in ‘Relevance’ and ‘Timeliness’ dimensions resulting in a lower overall score.
ConclusionWe propose our developed tool be used for comparing hospital-administrative data quality for applying the same standard across countries.
Platform enabling population-level imaging and data linkage in Scotland
Authors: Sutherland James , Nind Thomas , MacLeod Ruairidh , Brooks Andrew , Prodan Bianca , Krueger Susan , Jefferson Emily 
Published: September 2024

Scotland has more than five million people within a single health system, using a single central Picture Archiving and Commication System (PACS) for radiography data. This enabled the project team to build a research resource exceeding a petabyte of imaging from 2010 onwards, with open-source tooling to collate and de-identify images on demand. Image metadata, treatment and diagnostic records can be used to define large cohorts of patients then make the data available remotely to researchers in a Trusted Research Environment (TRE).
Original identifiable images are stored in one of three isolated zones with controlled data transfer to protect patient privacy and prevent inadvertent disclosure. Linkage to other records is performed in the second zone on de-identified images using encrypted patient identifiers. Automated screening with optical character recognition and natural language processing was implemented to identify and redact personally identifiable information before release to researchers in the third zone.
A recent extension to this system has provided an ongoing feed of routine imaging, which is securely shared with regional counterparts to ensure the minimal possible additional load is placed on clinical PACS resources and avoid duplicate requests.
The project launched in April 2022 and since then a variety of research projects have already used this environment and data representing millions of pounds of funding, some using large cohorts with historical data up to 14 years old, re-assessing historical scans with the benefit of subsequent diagnosis to investigate possible early warning signs of conditions including dementia and pre-cancerous lung nodules.
Guides visant à faciliter la mise en oeuvre et l’évaluation de la prescription sociale : leçons tirées du modèle « Accès aux ressources communautaires »
Authors: Saluja Kiran , Dahrouge Simone 
Published: September 2024

Résumé

La prescription sociale est une approche globale qui agit sur les déterminants sociaux de la santé. « Accès aux ressources communautaires » (ARC) est un programme de prescription sociale novateur aux services bilingues qui offre un point d’entrée unique pour les besoins en matière de santé et de services sociaux et qui permet d’apporter des changements dans les lieux de pratique dans le but d’aider les fournisseurs de soins primaires à mobiliser leurs patients, grâce à un intervenant-pivot non clinicien qui aide les patients à accéder aux ressources communautaires pertinentes. L’équipe du programme ARC a créé une trousse d’outils de prescription sociale qui contient des conseils pratiques sur l’établissement, la mise en oeuvre et l’évaluation de programmes de prescription sociale ainsi que sur le suivi des progrès. Les quatre guides du programme ARC sont facilement adaptables à divers milieux de pratique et de recherche.
Evaluation of Morphological and Cytological Variations in Colchicine-Induced M1 and M2 Generations of Bambara Groundnut (Vigna subterranea L.)
Authors: Alisha Tarra Syifa , Saptadi Darmawan , Damanhuri Damanhuri 
Published: September 2024

Kacang bambara (Vigna subterranea L.) memiliki potensi dalam mengamankan pasokan pangan dalam menghadapi perubahan iklim karena memiliki manfaat dari aspek kandungan gizi, kesehatan, dan agronominya. Keterbatasan sumberdaya genetik menghambat pengembangan varietas unggul kacang bambara di Indonesia. Pemuliaan mutasi menggunakan kolkisin merupakan salah satu metode untuk meningkatkan keragaman kacang bambara. Penelitian ini bertujuan untuk mengevaluasi keragaman morfologi dan sitologi pada dua generasi kacang bambara yang diinduksi oleh kolkisin pada konsentrasi yang berbeda. Eksperimen dilakukan di dua waktu dan lokasi yang berbeda, yaitu Maret-Juli 2022 di lapangan percobaan Fakultas Pertanian Universitas Brawijaya dan Maret-Juli 2023 di rumah kaca di wilayah Joyo Agung, Lowokwaru, Kota Malang, Jawa Timur. Perlakuan kolkisin dilakukan dengan metode tetes pada pucuk apikal bibit dengan konsentrasi yang berbeda (0, 0,1, 0,2, 0,3, dan 0,4%). Pengamatan karakteristik morfologi dan sitologi dilakukan pada generasi M1 dan M2. Perlakuan kolkisin mempengaruhi perubahan morfologi dan sitologi tanaman kacang bambara pada generasi M1 dan M2. Pada generasi M2, perlakuan kolkisin konsentrasi 0,4% meningkatkan lebar daun sebesar 31%, panjang daun sebesar 32%, waktu berbunga sebesar 28%, lebar biji sebesar 29%, panjang biji sebesar 47%, bobot 100 biji sebesar 3%, lebar stomata sebesar 20%, dan panjang stomata sebesar 25% dibandingkan dengan kontrol. Namun, perlakuan kolkisin menurunkan jumlah daun sebesar 30%, tinggi tanaman sebesar 1%, jumlah biji pertanaman sebesar 58%, bobot biji pertanaman sebesar 56%, dan kerapatan stomata sebesar 15% dibandingkan dengan kontrol. Perlakuan induksi kolkisin menyebabkan peningkatan jumlah kromosom pada generasi M2 sehingga dapat digunakan untuk meningkatkan variasi dan mengatasi keterbatasan sumber daya genetik kacang Bambara.
Pensando en tiempos de infancias
Authors: Oballe Silvia Gladys 
Published: September 2024

Se trata de un texto que aborda la situación que viven niños, niñas y adolescentes en el siglo XXI. ¿Qué es lo que les proponen padres, madres y docentes? ¿Cuál pareciera ser la situación de las familias y de la escuela? Cambios en cada una de dichas instituciones en virtud de las modificaciones generadas por los diversos avances de época, desde lo tecnológico hasta lo emocional, o la influencia de los medios de comunicación masiva. Señalamientos acerca de marcas que va generando la época en la constitución de las subjetividades.
Transpulmonary cardiac output with room temperature saline is accurate and tracks directional changes in anesthetized dogs
Authors: Cannarozzo Cheyenne J. , Araos Joaquin , Martin-Flores Manuel 
Published: September 2024

Abstract

OBJECTIVE
To assess the performance of transpulmonary thermodilution (TPTD) using room-temperature saline (CORT) and waveform-derived continuous CO (CCO) compared with TPTD using iced saline (COICED) as the indicator for measurements of CO in isoflurane-anesthetized dogs.

METHODS
8 Beagles aged 1 to 2 years (7.4 to 11.2 kg) were enrolled in this experimental study from March 21 to 31, 2023. Dogs were anesthetized with 0.01 mg/kg acepromazine, 5 to 6 mg/kg propofol, and isoflurane and were mechanically ventilated. Dogs were instrumented with a central venous catheter and a femoral arterial catheter equipped with a thermistor. The COICED, CORT, and pulse wave-derived CCO values were obtained at baseline, during infusions of phenylephrine and norepinephrine, and during blood withdrawal and replacement. Data were analyzed with a mixed effect model, Bland-Altman plots, and concordance. Percent error was calculated. P < .05 was used for significance.

RESULTS
Data were collected from 8 dogs. Significant effects of time and the interaction of time and method were found. Bland-Altman plots showed negligible bias with limits of agreement between −0.35 and 0.25 L/min for CORT versus COICED and −1.23 and 1.15 L/min for CCO versus COICED. Percent errors were 17.7% and 66.6%, respectively. In the 4-quadrant plots, the concordance rate was 95% and 68% for measurements obtained with CORT and for CCO, respectively.

CONCLUSIONS
Transpulmonary thermodilution using room temperature saline was accurate and able to track changes in CO. Continuous CO had a large percent error and low tracking ability.

CLINICAL RELEVANCE
Transpulmonary thermodilution using room temperature saline is reliable for monitoring CO and obviates the need for iced preparations in clinical scenarios.
Integrating Sustainability and Digitalization in Business Model Innovation. A Bibliometric Study
Authors: Ogrean Claudia , Herciu Mihaela , Tichindelean Mihai 
Published: September 2024

Abstract
The aim of the study is to get a comprehensive understanding of the research landscape at the nexus between business model innovation, sustainability and/or digitalization, in order to determine key research patterns and trends. Accordingly, the following objectives have guided the development of the paper: (a) to examine the dynamics and structure of the research output (articles and citations) on the topic; (b) to explore the network of the most impactful articles; (c) to trace the origins of the research on the topic; (d) to decipher current developments in the research on the topic; and (e) to search for emerging trends in the research on the topic. An advanced search of the SCOPUS database was conducted to identify the relevant literature available; 1195 articles (published between 2014 and 2023) were selected and exported in VOSviewer for bibliometric analysis. The results suggest the emergence of a niche research area in the broad strategic management field, bringing together four related (sub)topics: (1) circular economy and sustainable business models; (2) tools, frameworks and processes for sustainable business model innovation; (3) digitalization and business model transformation; (4) business models for societal and sustainability transitions. For this research area to crystallize, the identified emerging research trends – on digital innovation and technology; strategic management and analytical methods; supply chain and manufacturing; policy, governance and sustainability – need to be further explored, both individually (in search of refinement and clarity) and collectively (in search of consistency and synergy).
Uncovering crosstalk between AMPK and the ATF4-Integrated Stress Response
Authors: Smee Lindsey , Galloro Elise 
Published: September 2024

The reprograming of cellular metabolism in cancer cells is directly inter-related to their capacity for uncontrolled growth. As such, targeting of mitochondrial function has been explored as a therapeutic strategy in cancer. However, inhibition of mitochondria inevitably leads to activation of cellular stress pathways including the integrated stress response (ISR). The ISR includes as a key feature, increased activity of activating transcription factor 4 (ATF4), which goes on to up-regulate a range of gene targets to restore cellular homeostasis. Inhibition of mitochondria also can impair bioenergetic and biosynthetic capacity, which might activate AMP-activated protein kinase (AMPK), a cellular energy sensor that also orchestrates metabolic homeostasis. While the ISR and AMPK both critically regulate metabolism in cancer cells, the link between these mechanisms remains unclear. To address this gap, we tested effects of various energetic stress conditions in MEF cell systems deficient in AMPK activity. To comprehensively impair metabolic networks, we used nutrient starvation treatments in combination with silencing of the protein OPA1 which maintains organisational integrity of the mitochondrial cristae. Our results suggest that AMPK may be involved in suppressing the ISR upon mitochondrial disruption. To further explore, we took the alternative approach to test a range of mitochondrial targeting drugs in wildtype or AMPK-deficient MEF. To gain insight into roles of AMPK in the ISR and related adaptive gene responses, we analysed resulting transcriptomes. These results further revealed a regulatory link between AMPK and the ATF4-ISR, showing that AMPK loss hypersensitizes the cell to energetic stress. Our work uncovering the crosstalk between AMPK and the ATF4-ISR has potential to reveal novel interactions that could suggest metabolic liabilities that may be relevant for targeting in cancer cells.
Understanding the Contributions of the Hippocampus
Authors: Reid Heather 
Published: September 2024

The hippocampus plays an important role in human memory, with its anterior portion contributing to coarse-grained representations and its posterior portion contributing to fine-grained ones (Poppenk et al., 2013). My USRA project is focused on understanding the role of the hippocampus in a potential third type of memory representation; a general synthesis of stimuli.
Beyond memory, the hippocampus has also been hypothesize to influence clinical disorders. For instance, preliminary research in our lab has found meta-cognitive memory abilities to be organized into factors resembling clinical disorders, when organized by variance in brain structure. My USRA project also aims to understand the contribution of the hippocampus to clinical disorders.
My role in this project has been to develop administrative and experimental structure for the protocol, which involves extensive testing. Participants will complete approximately 27 hours of memory tasks, designed to evaluate the nature of their memory, and whether it is oriented towards detail, gist, or a synthesis of all stimuli. To do so, I have developed an extensive task of reading and evaluating reviews, as well as a recall task of lab-generated stories. Participants will also complete approximately 3-4 hours of online questionnaires, administered through Qualtrics. Over the summer, I conducted research to identify validated questionnaires that assess metacognitive abilities, in the domains of memory, attention, language, motor control, social cognition and perception. Results on these questionnaires will be used to validate preliminary findings on the relationship between metacognitive memory, brain variance and sub-threshold levels of clinical disorders, and to investigate whether these findings expand to other forms of metacognition. Finally, participants will complete a number of structural and functional MRI scans (including DTI).

This work may help us understand the pure science of the function of human memory, as well as the nature of clinical disorders.
Antagonistic insulin-like signaling influencing glucose regulation in C. elegans
Authors: Wilson Mason 
Published: September 2024

The insulin/ IGF-signaling (IIS) is an evolutionary conserved signaling pathway within eukaryotic organisms that regulates glucose metabolism and cell division. The nematode, C. elegans is an excellent model for exploring IIS as they have 40 insulin-like peptides that act on a single receptor, DAF-2. We aim to explore the relationships between IIS and glucose metabolism, focusing on the antagonistic insulin-like peptide, INS-17 and its influence over FDGT-1 (facilitated glucose transporter 1). FDGT-1 is expressed throughout the nematode, including the basolateral membrane of intestinal cells and where it is theorized to export glucose to the surrounding somatic cells rather than absorb it from the intestinal tract. We hypothesize that IIS controls transcription of FDGT-1 and antagonistic peptides should lead to a decrease in FDGT-1 transcription, resulting in the increased lifespan and increased fat accumulation observed in daf-2(lf) loss of function and ins-17(oe) over expressing strains. In this study, survival assays are used to assess the impact which high-glucose content has on lifespan, along with Oil Red O (ORO) lipid staining to visualize lipid accumulation amongst conditions and protein quantification of FDGT-1:GFP to evaluate FDGT-1 protein levels. Our findings are consistent with the idea of low insulin signaling leading to extended lifespan as daf-2(lf) lived significantly longer than WT in both 0% and 2% glucose conditions and ins-17(oe) living significantly longer than wildtype in 2% glucose conditions. The ORO lipid staining revealed that high glucose conditions and low insulin signaling result in lipid accumulation within the nematode. Using the fdgt-1:gfp strain, we were able to determine an increase in the FDGT-1 in the presence of glucose, suggesting FDGT-1 expression is influenced by glucose. These findings aim to further our understanding of IIS regulating glucose uptake and metabolism, along with the significance of the FDGT-1 glucose transporter.