bluuebunny/crossref_metadata_2025_split huggingface dataset:
The climatic impact of food consumption in a representative sample of Irish adults and implications for food and nutrition policy
Authors: Hyland John J , Henchion Maeve , McCarthy Mary , McCarthy Sinéad N 
Published: September 2016

AbstractObjectiveTo evaluate the greenhouse gas emissions (GHGE) associated with the diet of Irish adults.DesignGHGE were estimated by applying conversion factors to habitual food consumption data taken from the National Adult Nutrition Survey, which was representative of the population. Descriptive analyses were undertaken for GHGE for the total population, as well as accounting for energy misreporting and across categories of sociodemographic and socio-economic factors and tertiles of emissions.SettingRepublic of Ireland.SubjectsAdults aged 18–87 years (n1500).ResultsThe GHGE derived from daily dietary intakes was estimated as 6·5 kg of CO2equivalents (CO2eq) per person. Males, younger consumers, those with secondary education and student employment status were associated with significantly higher GHGE. Red meat was the highest contributor to GHGE with 1646 g CO2eq arising from a mean intake of 47 g/d. Dairy and starchy staples were the next largest dietary GHGE sources, with mean daily emissions of 732 g CO2eq and 647 g CO2eq, respectively. The lowest emissions were associated with consumption of vegetables, fruits and legumes/pulses/nuts.ConclusionsBased on profiling using actual food consumption data, it is evident that one single measure is not sufficient and a range of evidence-based mitigation measures with potential to lower emissions throughout the food chain should be considered. The research contributes towards an improved understanding of the climatic impact of the dietary intakes of Irish adults and can serve to inform a sustainability framework to guide action in food and nutrition policy development.
A cross-sectional observation on habitual non-alcoholic beverage consumption among adolescents from four Irish post-primary schools
Authors: Millar Sophie , O’Donoghue Megan , McNulty Breige , Kirwan Laura , McKevitt Aideen 
Published: September 2016

AbstractObjectiveNo up-to-date data on the dietary intake of Irish adolescents are available. The aim of the present pilot study was to obtain and compare cross-sectional information on habitual adolescent beverage consumption between four distinct post-primary schools in the Republic of Ireland, in 2014–2015.DesignA cross-sectional observation study. A beverage consumption questionnaire was used to obtain data on beverage intake and influences on consumption.SettingFour post-primary mixed-sex schools in Ireland representing the following school classifications were selected for the study: urban fee-paying, urban disadvantaged, rural fee-paying and rural disadvantaged.SubjectsStudents (n 761) aged 12–18 years.ResultsData were analysed by Kruskal–Wallis (non-parametric) ANOVA to compare the distribution of beverage consumption across the schools. Water was the most highly consumed beverage among students from all four schools (median 1425 ml/d). Students from urban and rural disadvantaged schools reported a significantly higher volume of carbonated beverage intake than students from fee-paying schools. Students from an urban disadvantaged school also reported a significantly higher volume of carbonated beverage and energy drink intake compared with the other three schools. Students from an urban fee-paying school reported the highest consumption of water, while rural disadvantaged school students were the biggest consumers of tea and milk.ConclusionsSignificant differences in beverage consumption (ml/d) were reported by adolescents from four schools in Ireland. Surveillance on current beverage consumption trends among adolescents is vital to guide policies and interventions, and for appropriate targeting of resources.
An Evolving Landscape: From Information Gatekeeper to Knowledge Professional
Authors: Bradbury Jane , Beaumont Jon , Barlow Tim 
Published: September 2016

AbstractThis paper is based on a presentation of the same title given by Jane Bradbury, Head of Knowledge and Information at the law firm Slaughter and May, at the inaugural seminar of the BIALL Knowledge Management Group on 9th May 2016. The article has been compiled by the other two authors, Jon Beaumont and Tim Barlow, and so not all of the opinions expressed are attributable to Jane. The authors are also indebted to Anne Ashdown, of recruitment firm tfpl, who presented at the same seminar on the subject of recruitment for legal knowledge management (KM) roles and whose observations are also incorporated in the article. The paper considers the increasing impact of KM on the work of library and information professionals in law firms. It discusses the related role of professional support lawyers (PSLs), the knowledge “hot topics” which are driving evolution of the profession, the transferability of information skills, and opportunities for development and career progression beyond the traditional boundaries of library and information management.
The Challenge of Printed UK Official Publications: Improving Access at Warwick University Library
Authors: Riley Helen 
Published: September 2016

AbstractThis article by Helen Riley explains how changes in official publishing have affected the provision of official publications at Warwick University Library, and discusses the pros and cons of print versus online publications. It also explains how using and promoting good online databases may help to save staff time and shelf space at a time when library budgets are being curtailed.
Law Student Views on the Principles of a Legal Research Website: a User Experience Study
Authors: Intahchomphoo Channarong , Jeske Margo , Landriault Emily , Brown Michelle 
Published: September 2016

AbstractThe Principles of Legal Research (PLR) website of the University of Ottawa's Brian Dickson Law Library is a bilingual (English and French) online learning tool for all first year students in both Common Law and Civil Law.1 Law librarians use this e-learning website to facilitate teaching components such as student assignments and assessments. This user experience study aims to investigate law students’ real experience with the system. Their feedback will be used for future development planning as well as analysing user behaviour trends. The authors investigate the following aspects: accuracy of information, interface design, navigation system, Web 2.0, social media, and smartphone version.
Searching for wisdom in oncology care: A scoping review
Authors: Butlin Helen , Kinsella Elizabeth Anne , Garcia Carla , Bauman Glenn 
Published: September 2016

ABSTRACTObjective:The concept of “wisdom” is beginning to emerge in the oncology literature, raising questions concerning: (1) how the concept of wisdom is used in oncology literature; (2) the ways in which wisdom has been a focus of inquiry within oncology care; and (3) how wisdom is characterized when the term is used.Method:A scoping review, using Arksey and O'Malley's five-step framework, was undertaken to address these questions. In consultation with oncology reference librarians, “wisdom”- and “oncology”-related search terms were identified, and four electronic databases were searched: CINAHL, SocINDEX, PubMed, and PsychINFO. After removal of duplicates and application of inclusion and exclusion criteria, 58 records were identified and included for analysis.Results:The concept of wisdom was employed with a breadth of meanings, and 58 records were schematized into 7 genres, including: (1) empirical research with wisdom foregrounded as a study focus (n= 2); (2) empirical research articles where “wisdom” appears in the findings (n= 16); (3) a quality-improvement project where wisdom is an embedded concept (n= 1); (4) essays where wisdom is an aspect of the discussion (n= 5); (5) commentary/opinion pieces where wisdom is an aspect of its focus (n= 6); (6) personal stories describing wisdom as something gleaned from lived experience with cancer (n= 2); and (7) everyday/taken-for-granted uses of wisdom (n= 26).Significance of Results:The notion of wisdom has a taken-for-granted presence in the published oncology literature and holds promise for future research into patient and clinician wisdom in oncology care. Nonetheless, the terminology is varied and unclear. A scholarly focus on wisdom has not been brought to bear in cancer care to the degree it has in other fields, and research is in the early stages. Various characterizations of wisdom are present. If such a resource as “wisdom” exists, dwelling in human experiences and practices, there may be benefit in recognizing wisdom as informing the epistemologies of practice in oncology care.
Sub-molecular modulation of a 4f driven Kondo resonance by surface-induced asymmetry
Authors: Warner Ben , El Hallak Fadi , Atodiresei Nicolae , Seibt Philipp , Prüser Henning , Caciuc Vasile , Waters Michael , Fisher Andrew J. , Blügel Stefan , van Slageren Joris , Hirjibehedin Cyrus F. 
Published: September 2016

AbstractCoupling between a magnetic impurity and an external bath can give rise to many-body quantum phenomena, including Kondo and Hund’s impurity states in metals, and Yu-Shiba-Rusinov states in superconductors. While advances have been made in probing the magnetic properties of d-shell impurities on surfaces, the confinement of f orbitals makes them difficult to access directly. Here we show that a 4f driven Kondo resonance can be modulated spatially by asymmetric coupling between a metallic surface and a molecule containing a 4f-like moment. Strong hybridization of dysprosium double-decker phthalocyanine with Cu(001) induces Kondo screening of the central magnetic moment. Misalignment between the symmetry axes of the molecule and the surface induces asymmetry in the molecule’s electronic structure, spatially mediating electronic access to the magnetic moment through the Kondo resonance. This work demonstrates the important role that molecular ligands have in mediating electronic and magnetic coupling and in accessing many-body quantum states.
Real-time encoding and compression of neuronal spikes by metal-oxide memristors
Authors: Gupta Isha , Serb Alexantrou , Khiat Ali , Zeitler Ralf , Vassanelli Stefano , Prodromakis Themistoklis 
Published: September 2016

AbstractAdvanced brain-chip interfaces with numerous recording sites bear great potential for investigation of neuroprosthetic applications. The bottleneck towards achieving an efficient bio-electronic link is the real-time processing of neuronal signals, which imposes excessive requirements on bandwidth, energy and computation capacity. Here we present a unique concept where the intrinsic properties of memristive devices are exploited to compress information on neural spikes in real-time. We demonstrate that the inherent voltage thresholds of metal-oxide memristors can be used for discriminating recorded spiking events from background activity and without resorting to computationally heavy off-line processing. We prove that information on spike amplitude and frequency can be transduced and stored in single devices as non-volatile resistive state transitions. Finally, we show that a memristive device array allows for efficient data compression of signals recorded by a multi-electrode array, demonstrating the technology’s potential for building scalable, yet energy-efficient on-node processors for brain-chip interfaces.
Structure–function insights reveal the human ribosome as a cancer target for antibiotics
Authors: Myasnikov Alexander G. , Kundhavai Natchiar S. , Nebout Marielle , Hazemann Isabelle , Imbert Véronique , Khatter Heena , Peyron Jean-François , Klaholz Bruno P. 
Published: September 2016

AbstractMany antibiotics in clinical use target the bacterial ribosome by interfering with the protein synthesis machinery. However, targeting the human ribosome in the case of protein synthesis deregulations such as in highly proliferating cancer cells has not been investigated at the molecular level up to now. Here we report the structure of the human 80S ribosome with a eukaryote-specific antibiotic and show its anti-proliferative effect on several cancer cell lines. The structure provides insights into the detailed interactions in a ligand-binding pocket of the human ribosome that are required for structure-assisted drug design. Furthermore, anti-proliferative dose response in leukaemic cells and interference with synthesis of c-myc and mcl-1 short-lived protein markers reveals specificity of a series of eukaryote-specific antibiotics towards cytosolic rather than mitochondrial ribosomes, uncovering the human ribosome as a promising cancer target.
Next generation sequencing data of a defined microbial mock community
Authors: Singer Esther , Andreopoulos Bill , Bowers Robert M. , Lee Janey , Deshpande Shweta , Chiniquy Jennifer , Ciobanu Doina , Klenk Hans-Peter , Zane Matthew , Daum Christopher , Clum Alicia , Cheng Jan-Fang , Copeland Alex , Woyke Tanja 
Published: September 2016

AbstractGenerating sequence data of a defined community composed of organisms with complete reference genomes is indispensable for the benchmarking of new genome sequence analysis methods, including assembly and binning tools. Moreover the validation of new sequencing library protocols and platforms to assess critical components such as sequencing errors and biases relies on such datasets. We here report the next generation metagenomic sequence data of a defined mock community (Mock Bacteria ARchaea Community; MBARC-26), composed of 23 bacterial and 3 archaeal strains with finished genomes. These strains span 10 phyla and 14 classes, a range of GC contents, genome sizes, repeat content and encompass a diverse abundance profile. Short read Illumina and long-read PacBio SMRT sequences of this mock community are described. These data represent a valuable resource for the scientific community, enabling extensive benchmarking and comparative evaluation of bioinformatics tools without the need to simulate data. As such, these data can aid in improving our current sequence data analysis toolkit and spur interest in the development of new tools.
Mesoporous Silica Supported Pd-MnOx Catalysts with Excellent Catalytic Activity in Room-Temperature Formic Acid Decomposition
Authors: Jin Min-Ho , Oh Duckkyu , Park Ju-Hyoung , Lee Chun-Boo , Lee Sung-Wook , Park Jong-Soo , Lee Kwan-Young , Lee Dong-Wook 
Published: September 2016

AbstractFor the application of formic acid as a liquid organic hydrogen carrier, development of efficient catalysts for dehydrogenation of formic acid is a challenging topic, and most studies have so far focused on the composition of metals and supports, the size effect of metal nanoparticles, and surface chemistry of supports. Another influential factor is highly desired to overcome the current limitation of heterogeneous catalysis for formic acid decomposition. Here, we first investigated the effect of support pore structure on formic acid decomposition performance at room temperature by using mesoporous silica materials with different pore structures such as KIE-6, MCM-41, and SBA-15, and achieved the excellent catalytic activity (TOF: 593 h−1) by only controlling the pore structure of mesoporous silica supports. In addition, we demonstrated that 3D interconnected pore structure of mesoporous silica supports is more favorable to the mass transfer than 2D cylindrical mesopore structure, and the better mass transfer provides higher catalytic activity in formic acid decomposition. If the pore morphology of catalytic supports such as 3D wormhole or 2D cylinder is identical, large pore size combined with high pore volume is a crucial factor to achieve high catalytic performance.
Serum sclerostin levels in renal cell carcinoma patients with bone metastases
Authors: Wibmer C. , Amrein K. , Fahrleitner-Pammer A. , Gilg M. M. , Berghold A. , Hutterer G. C. , Maurer-Ertl W. , Gerger A. , Leithner A. , Pichler M. , Szkandera J. 
Published: September 2016

AbstractSclerostin has been proposed as a potent inhibitor of bone formation. Sclerostin antibodies are under clinical development to treat osteoporosis and metastatic bone disease. Serum sclerostin level is elevated in multiple myeloma, an osteolytic malignancy, where it might serve as predictive marker for the use of sclerostin-directed antibodies. As renal cell carcinoma (RCC) patients often present with osteolytic metastases, we aimed to investigate serum sclerostin levels in RCC patients. Our study included 53 RCC patients (19 with bone metastases, 25 with visceral metastases and 9 with localized disease) and 53 age- and gender-matched non-osteoporotic controls. Frozen serum samples were subjected to sclerostin quantitative sandwich ELISA. The mean serum sclerostin levels of RCC patients and controls were 45.8 pmol/l and 45.1 pmol/l, respectively (p = 0.86). Analysis of variance showed no difference between the subgroups of RCC patients with regard to visceral or bone metastases or localized disease (p = 0.22). There was no significant association between eGFR (estimated glomerular filtration rate) and serum sclerostin levels in RCC patients (r = 0.05; p = 0.74) and controls (r = 0.06; p = 0.68). Our results indicate that serum sclerostin levels appear not to be a valuable biomarker to assess the occurrence of bone metastases in RCC patients.
TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A
Authors: Fan Wenchun , Wu Mengge , Qian Suhong , Zhou Yun , Chen Huanchun , Li Xiangmin , Qian Ping 
Published: September 2016

AbstractThe members of tripartite-motif containing (TRIM) protein participate in various cellular processes and play an important role in host antiviral function. TRIM proteins exert their antiviral activity either directly by degrading viral proteins through their E3 ligase activity, or indirectly by promoting host innate immunity. This study demonstrated for the first time that TRIM52 is a novel antiviral TRIM protein against Japanese encephalitis virus (JEV) infection. Overexpression of TRIM52 restricted JEV replication in BHK-21 and 293T cells. In addition, JEV nonstructural protein 2A (NS2A) is a protein that interacts with TRIM52. Their interaction degraded NS2A in a proteasome-dependent manner via the E3 ligase activity of TRIM52. Thus, TRIM52 is a novel antiviral TRIM protein, and it exerted antiviral activity against JEV infection by targeting and degrading viral NS2A.
Evaluating the performance of infectious disease forecasts: A comparison of climate-driven and seasonal dengue forecasts for Mexico
Authors: Johansson Michael A. , Reich Nicholas G. , Hota Aditi , Brownstein John S. , Santillana Mauricio 
Published: September 2016

AbstractDengue viruses, which infect millions of people per year worldwide, cause large epidemics that strain healthcare systems. Despite diverse efforts to develop forecasting tools including autoregressive time series, climate-driven statistical and mechanistic biological models, little work has been done to understand the contribution of different components to improved prediction. We developed a framework to assess and compare dengue forecasts produced from different types of models and evaluated the performance of seasonal autoregressive models with and without climate variables for forecasting dengue incidence in Mexico. Climate data did not significantly improve the predictive power of seasonal autoregressive models. Short-term and seasonal autocorrelation were key to improving short-term and long-term forecasts, respectively. Seasonal autoregressive models captured a substantial amount of dengue variability, but better models are needed to improve dengue forecasting. This framework contributes to the sparse literature of infectious disease prediction model evaluation, using state-of-the-art validation techniques such as out-of-sample testing and comparison to an appropriate reference model.
Coffee and cancer risk: A meta-analysis of prospective observational studies
Authors: Wang Anqiang , Wang Shanshan , Zhu Chengpei , Huang Hanchun , Wu Liangcai , Wan Xueshuai , Yang Xiaobo , Zhang Haohai , Miao Ruoyu , He Lian , Sang Xinting , Zhao Haitao 
Published: September 2016

AbstractMeta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg’s and egger’s test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48–0.99, I2 = 73.4%, P = 0.044), 0.87 (95% CI = 0.78–0.96, I2 = 28.4%, P = 0.007), 0.46 (95% CI = 0.37–0.57, I2 = 0%, P = 0), 0.89 (95% CI = 0.84–0.93, I2 = 30.3%, P = 0.003), 0.73 (95% CI = 0.67–0.80, I2  = 0%, P = 0) and 0.89 (95% CI = 0.80–0.99, I2  = 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26–3.75, I2  = 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67–0.79 for liver cancer, RR = 0.97, 95% CI = 0.96–0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85–0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.
Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen)
Authors: Gao Hongwei , Sun Wen , Zhao Jianping , Wu Xiaxia , Lu Jin-Jian , Chen Xiuping , Xu Qiong-ming , Khan Ikhlas A. , Yang Shilin 
Published: September 2016

AbstractFour novel compounds (1–4) as well as fourteen reported compounds (5–18) were isolated and purified from Salvia miltiorrhiza Bunge (Danshen). The structures of novel compounds were determined by 1D and 2D NMR, HRESIMS data, etc. The anti-inflammatory properties of all the compounds on RAW264.7 macrophages and their cytotoxicity on H1299 and Bel-7402 cell lines coupled with a structure-activity relationship (SAR) were investigated. Compound 4 demonstrated the best anti-inflammatory activity and was chosen for further research. Compound 4 greatly suppressed secretion of nitric oxide (NO), tumor necrosis factor (TNF)-α and interleukin-6 (IL-6) in the RAW264.7 macrophages stimulated by LPS. Additionally, the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was decreased and the nuclear translocation of NF-κB was attenuated after treatment with compound 4in vitro. Compound 4 was able to dramatically inhibit LPS-induced activation of JNK1/2 and ERK1/2 and remarkably disrupted the TLR4 dimerization in LPS-induced RAW264.7 macrophages. Thus, the new compound 4 suppressed LPS-induced inflammation partially is due to the blocking TLR4 dimerization. In addition, the anti-cancer activity investigation indicated that most of isolated compounds exhibited cytotoxicity and the SAR analysis showed that the intact D ring was indispensable and unsaturated D ring played vital role.