bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-Layer Artificial Neural Network for Pricing Multi-Asset European Option
Authors: Zhou Zhiqiang , Wu Hongying , Li Yuezhang , Kang Caijuan , Wu You 
Published: September 2024

This paper studies an artificial neural network (ANN) for multi-asset European options. Firstly, a simple three-layer ANN-3 is established with undetermined weights and bias. Secondly, the time–space discrete PDE of the multi-asset option is given and the corresponding discrete data are fed into the ANN-3. Then, using least squares error as the objective function, the weights and bias of ANN-3 are trained well. Numerical examples are carried out to confirm the stability, accuracy and efficiency. Experiments show the ANN’s relative error is about 0.8%. This method can be extended into multi-layer ANN-q(q>3) and extended into American options.
Comprehensive Microbiological and Metagenomic Analysis of the Guillain–Barré Syndrome Outbreak in Lima, 2019
Authors: Rojas Jesús D. , Ramos Mariana , Cruz Cristopher , Long Kyle A. , Voegtly Logan J. , Meza Rina , Espinoza Nereyda , Ttito Ana Ramos , Cáceres Hugo Umeres , Cuentas Alejandro Llanos , Meza Yocelinda , Troncos Gilda , Poly Frédéric M. , Paskey Adrian C. , Lueder Matthew R. , Rice Gregory K. , Cer Regina Z. , Bishop-Lilly Kimberly A. , Silva María , Grogl Max 
Published: September 2024

In 2018/2019, two large Guillain–Barré Syndrome (GBS) outbreaks took place in Peru. Here, we report a comprehensive analysis of biological samples from GBS patients from the 2019 outbreak. We applied metagenomic, microbiologic, and serological analyses to different biological samples collected from GBS patients. Further phenotypic and genomic characterization was conducted on Campylobacter jejuni isolates from GBS samples. Microbiologic and metagenomic analyses revealed several patients with multiple co-infections, yet no common infectious agents were found other than C. jejuni. Four C. jejuni isolates were isolated from rectal swabs. Twenty-one patients had detectable IgG serum antibodies related to C. jejuni, of whom seven had IgM antibodies. Genomic analyses showed that these four strains were clonal (ST2993) and contained the class A lipooligosaccharide biosynthesis locus. These results further support the idea that that C. jejuni is the etiological agent that triggered the GBS outbreak in Peru in 2019 and that the strains are not restricted to Peru, hence could be regarded as a broad public health concern. Furthermore, though we cannot delineate the role played by co-infections in GBS development, results obtained herein highlight metagenomic analysis as a potential new tool for depicting a yet unknown area of research in GBS.
Risks of AI Applications Used in Higher Education
Authors: Schaeffer Donna , Coombs Lori , Luckett Jonathan , Marin Marvin , Olson Patrick 
Published: September 2024

As artificial intelligence (AI) tools become more widely used in higher education, we must pay attention to the risks that can emerge. AI projects, whether applied in classroom learning or used for decision-making regarding admissions, financial aid allocation, or hiring, must include attention to governance and compliance issues, regardless of the project’s scope and scale. Concerns highlighted in this work include transparency, user privacy, data confidentiality, data integrity, and system availability, however, we note that this is a non-exhaustive list of risks. In this paper, risk assessment is defined, and two examples of risk management frameworks, namely the United States National Institute of Standards and Technology Artificial Intelligence Risk Management Framework and the non-profit humanitarian effort ForHumanity’s Independent Audit of AI, Algorithmic, and Autonomous Systems are briefly described. We identify characteristics of AI applications that need to be assessed for vulnerabilities they may present, such as bias and discrimination. This paper aims to facilitate discussion among stakeholders about the risks that may be encountered from using AI in higher education, as well as to suggest ways developers, decision-makers, and users can mitigate these risks. Much discussion and published literature has focused on risk management frameworks designed for large organizations or enterprises or frameworks that do not consider risks specific to AI. We hope that decision-makers carefully consider the risks, perform due diligence when implementing AI applications, and create a plan for mitigating the risks. This research supports e-learning practice because students and faculty are embracing AI applications. Leaders and decision-makers in higher education need to be proactive in protecting their varied stakeholders. The paper asks what risks may be encountered by institutions of higher education when using AI tools and products in the classroom and for various aspects of decision-making and if published frameworks can mitigate these risks.
RESULTS OF DIFFERENT PLANT PROTECTION MEANS AGAINST CODLING MOTH IN APPLE PLANTATIONS
Authors: Кочкина А.М. , Каширская Н.Я. 
Published: September 2024

В условиях ЦЧР отмечено увеличение численности и вредоносности яблонной плодожорки, которая является основным вредителем в период роста и созревания плодов. Инсектициды широкого спектра действия следует заменять высокоселективными препаратами, которые избирательно действуют на вредные объекты и являются малоопасными для полезных элементов агробиоценоза и окружающей среды. В 2019–2021 гг. были выполнены исследования в насаждениях яблони ФГБНУ «ФНЦ им. И.В. Мичурина» на сорте Богатырь. Краткосрочный прогноз сроков проведения защитных мероприятий осуществляли на основе подсчёта суммы эффективных температур и наблюдениями за началом массового лёта бабочек первого и второго поколений с помощью использования феромонных ловушек. Биологическая эффективность препаратов из группы регуляторов роста и развития насекомых (кораген, герольд, атаброн) колебалась в пределах 94–98%. Использование препаратов из группы регуляторов роста и развития насекомых наряду с авантом, КЭ (0,35 л/га) в период начала отрождения личинок и калипсо, КС (0,4 л/га), обладающего пролонгированным действием против яблонной плодожорки обеспечивает эффективность до 97%.
An increase in number and harmfulness of codling moth is observed in the Central chernozem region where the moth is the main pest during the growing season and fruit ripening. Broad spectrum insecticide should be replaced by highly selective chemicals which act selectively on objects and are not so dangerous for useful elements of agrobiocenosis and environment. The investigations of 2019–2021 were carried out in apple plantations of the FSSI “I.V. Michurin FSC” on Bogatyr variety. Short term forecast of the seasonal procedures for plant protection was carried out on the base of calculation of the effective temperatures sum and observation of initiation of mass moth spread of the first and second generation with the use of pheromone traps. Biological efficiency of chemicals from the group of the growth regulators and pest management (coragen, gerold, atabron) varied within 94–98%. The use of such preparation together with avant, CE ( 0,35 l/ha ) in the period way out of larvae and calypso, CS (0,4 l/ ha) having long-term effect against codling moth provide the effective to 97%.
REACTION OF APPLE TREE PLANTS TO TRANSFORMATION WATERTEMPERATURE REGIME OF THE CENTRAL CHERNOZEM REGION
Authors: Цуканова Е.М. , Ткачев Е.Н. 
Published: September 2024

Приведены результаты подробного анализа температурного и водного режима Центрального Черноземья на последние 25 лет. Выявлены существенные изменения температурных и влажностных характеристик территории. Круглогодичное изучение реакции плодовых растений на стрессоры гидротермического режима позволило установить наиболее уязвимые периоды в годичном цикле их развития и закономерности реакции обменных систем на воздействие стрессоров. Выявлены существенные изменения длительности периода и сроков вхождения и выхода растений яблони в состояние глубокого покоя — отмечен не только ранний выход растений из состояния глубокого покоя (уже в середине — конце декабря), но и значительное сокращение этого периода.
The results of a detailed analysis of the temperature and water regime of the Central Black Earth Region for the last 25 years are presented. Significant changes in the temperature and humidity characteristics of the territory were revealed. Year-round study of the response of fruit plants to stressors of the hydrothermal regime made it possible to establish the most vulnerable periods in the annual cycle of their development and the patterns of reaction of metabolic systems to the influence of stressors. Significant changes in the duration of the period and timing of the entry and exit of apple tree plants into a state of deep dormancy were revealed — not only an early exit of plants from a state of deep dormancy was noted (already in the middle — end of December), but also a significant reduction in this period.
The diffusion of tempone spin probe in poly-D,L-lactide and polymethylmethacrylate plasticized with sub- and supercritical carbon dioxide
Authors: Попова А.А. , Голубева Е.Н. 
Published: September 2024

Методом ЭПР оценены коэффициенты вращательной и трансляционной подвижности спинового зонда ТЕМПОН в полилактиде (ПЛА) и полиметилметакрилате (ПММА), пластифицированных сверх(СК)- и суб(СУБ)-критическим СО2. Коэффициенты трансляционной диффузии ТЕМПОН в системе ПММА-СК-СО2, на три порядка меньше, чем в ПЛА-СК-СО2, и имеют значения порядка 10-4 и 10-11 м2/с соответственно. Энергия активации вращения ТЕМПОН в ПЛА-СК-СО2 составляет 22 ± 5 кДж/моль. При импрегнации ПЛА зондом в субкритических условиях на протяжении всего эксперимента преимущественной является десорбция радикала. Спектр ТЕМПОН в ПЛА-СУБ-СО2 представляет собой суперпозицию узкого сигнала, аналогичного спектру ТЕМПОН в ПЛА-СК-СО2, а также широкого изотропного сигнала, вызванного магнитным концентрированием зондов ТЕМПОН в приповерхностном слое полимера. Снижение локальной концентрации со временем сопровождается появлением вращательной анизотропии в спектрах частиц второго типа. Полученные результаты свидетельствуют о преимуществах использования СК-СО2, как растворителя для импрегнации полимеров, обусловленных, прежде всего, высокими значениями коэффициентов диффузии.
The rotational and translational coefficients of the TEMPONE spin probe mobility were studied by ESR spectroscopy in the PLA and PMMA-based polymers plasticized with supercritical as well as subcritical carbon dioxide. Translational diffusion coefficients of TEMPONE in the PMMA-SC-CO2, system are 3 times inferior in comparison to PLA-SC-CO2 and the corresponding values are of 10-14 and 10-11 m2/s order of magnitude. The rotation activation energy of a value 22±5 kJ/mole was determined for the TEMPONE rotation in PLA-SC-CO2. It was found out that desorption of the radical exceeds TEMPONE diffusion into bulk PLA under subcritical conditions during the experimental period. Spectra of TEMPONE in PLA-SUB-CO2 turned out to be a superposition of two signals: a narrow one, which is similar to that of TEMPONE in PLA-SC-CO2, and a broad isotropic one caused by the TEMPONE paramagnetic particles accumulation in a polymer volume proximate to the surface. As local concentration decreases with time, the rotational anisotropy is exposed in the latter signal. The study gives an outlook on the SC-CO2 use as promising media to the polymer impregnation primarily taking into consideration both it’s and solutes’ higher mass diffusivity.
Some methodological aspects of solid phase–supercritical fluid equilibria modeling
Authors: Восков А.Л. , Демченко А.М. , Иванов А.С. , Лоскутова С.П. , Константинова Н.М. , Воробей А.М. , Костенко М.О. , Паренаго O.O. 
Published: September 2024

Термодинамическое моделирование растворимости фармпрепаратов в сверхкритических флюидах необходимо для оптимизации процессов экстракции, очистки, микронизации и т. п. В работе на примере тройных систем СО2—этанол—аспирин и СО2—диметилсульфоксид (DMSO)—сульфат сальбутамола показана возможность использования для этих целей упрощенных моделей на основе кубического уравнения состояния Пенга—Робинсона. В нем описаны фазовые равновесия в двойных системах СО2—этанол при р = 0,1—12 МПа и Т= 290—345 К, а также СО2— DMSO при р = 0,5—18 МПа и Т= 275—50 К. В случае тройных систем успешно аппроксимированы данные по растворимости фармпрепаратов в смешанных растворителях. Для аспирина использовали имеющиеся экспериментальные данные при р = 7,5—35 МПа, Т = 298—328 К, х(С2Н5ОН) = 0 и 3 мол. %. Растворимость сульфата сальбутамола в смеси СО2 и DMSO была измерена визуально в термостатируемой ячейке постоянного объема при р = 8,6—21,7 МПа и Т= 313—323 К. Хотя построенные модели описывают фазовые равновесия, они не согласуются с данными по плотности флюида, особенно для богатых полярными компонентами составов. Однако, это не препятствует использованию кубических уравнений состояния для описания растворимости фармпрепаратов во флюидных системах.
Thermodynamic modeling of pharmaceutical drugs solubility in supercritical fluids is necessary of optimization of extraction, purification, micronization and other processes. The CO2-ethanol-aspirin and CO2—dimethylsulfoxide (DMSO)—salbutamol sulfate ternary systems were used to show possibility of application of simplified models based on Peng—Robinson cubic equation of state. They were used for descri ption of phase equilibria in the CO2—ethanol binary subsystem at p=0.1—12 MPa and T = 290—345 K and in the CO2—DMSO binary subsystem at p = 0.5—18 MPa and T = 275—350 K. In the case of ternary systems, the data on the pharmaceuticals solubility in the mixed solvents were successfully approximated. Existing data at p = 7.5—35 MPa, T = 298—328 K, x(C2H5OH) = 0 and 3 mol. % were used for aspirin. Salbutamol sulfate solubility in the CO2—DMSO mixture was measures in this work at p = 8.6—21.7 MPa and T = 313—323 K by means of visual method in the thermostatic cell of constant volume. Although the obtained models describe phase equilibria, they disagree with fluid density data, especially for composition that are rich with polar components. Nevertheless, it doesn’t cause problems with usage of cubic equations of state for description of pharmaceuticals solubility in the fluid-based systems.
PHASE EQUILIBRIA IN THE SYSTEM ND3 -WATER-NITRIC ACID--TODGA-CO2 AND THE EFFICIENCY OF SUPERCRITICAL FLUID EXTRACTION OF NEODYMIUM IONS
Authors: ЗУЕВ Я. И. , КОСТЕНКО М. О. , СИНЁВ М. Ю. , ПАРЕНАГО О. О. , БАРАНОВСКАЯ В. Б. 
Published: September 2024

Изучены некоторые равновесия в системе Nd3+-вода-азотная кислота-ТОДГА- CO2 (ТОДГА - N,N,N',N'-тетраоктилдигликольамид, или тетра-н-октиламид дигликолевой кислоты) и эффективность экстракции ионов Nd3+ из водных растворов в фазу сверхкритического (СК) CO2 при 313-353 К и 18,0-40,0 МПа. Показано, что в отсутствие ТОДГА переход ионов Nd3+ в СК-фазу не происходит. Эффективность экстракции возрастает при снижении температуры и с увеличением концентрации азотной кислоты (САК) в водном растворе. При 313 К, САК > 1,5 моль/л, содержании ТОДГА не менее 100 моль/г-ат. Nd и давлении CO2, обеспечивающем полное растворение ТОДГА (> 19,0 МПа), наблюдается полный переход Nd3+ в СК-фазу. С ростом содержания в системе ионов неодима происходит увеличение давления и количества CO2, необходимое для полного растворения ТОДГА. Это связано, по-видимому, со снижением интенсивности межмолекулярных взаимодействий в СК-фазе при переходе в нее полярных комплексов Nd с ТОДГА и нитрат-ионами.
Some equilibria in the system Nd3+-water-nitric acid-TODGA-CO2 (TODGA - N,N,N',N'-tetraoctyl diglycolamide) and the efficiency of extraction of Nd3+ ions from aqueous solutions into the supercritical (SC) CO2-based phase at 313-353 K and 180-400 bar were studied. It has been shown that in the absence of TODGA, the transfer of Nd3+ ions to the SC-phase does not occur. The extraction efficiency increases with decreasing temperature and with increasing concentration of nitric acid (CNA) in the aqueous solution. At 313 K, CNA ≥ 1.5 mol/l, TODGA content not less than 100 mol/g-at. Nd and CO2 pressure ensuring complete dissolution of TODGA (> 19 MPa), a complete transfer of Nd3+ to the SC-phase is observed. As the content of neodymium ions in the system increases, the pressure and amount of CO2 required for complete dissolution of TODGA increases too. This is apparently due to a decrease in the intensity of intermolecular interactions in the SC-phase at increasing concentration in it of large and polar Nd complexes with TODGA and nitrate ions.
Eficiência do Lecanemabe no manejo da Doença de Alzheimer: uma revisão integrativa
Authors: Marques Victória Souza , Ricardo Vieira Bittencourt  , Cecília Soares de Oliveira  , Julyana Eulália Pereira Pessoa  , Maria Ester Gonçalves Ferreira Cavalcanti Manso  , Bruno Oliveira Góes  , Camilla Catarina Braz de Albuquerque pontes Lopes  , Leticia Melo Guimarães Pinto  , Wilson Moraes Amaral Júnior  , Rostand Ramos de Lima Cavalcanti Filho  , Hulfshoff Damasceno Gama  , Paulo Brian Fagundes  , João Vítor Tomaz Ribeiro  , Franciele Rabelo Braga  , Maria Eduarda Lapa Nogueira Lima  , Walter Borges de Almeida  , Natália Caminha Freire de Albuquerque  , Bruna Lima Farias Batista  
Published: September 2024

Introdução: O lecanemabe é um anticorpo monoclonal utilizado no tratamento da doença de Alzheimer, agindo especificamente nos oligômeros de beta-amiloide solúveis, com o intuito de facilitar a remoção pelo sistema imunológico, reduzindo a carga de beta-amiloide no cérebro. Objetivo: avaliar os impactos do lecanemabe no tratamento da Doença de Alzheimer. Métodos: Consiste em uma revisão integrativa realizada através das bases Scopus, PubMed® e SciELO, utilizando os descritores Lecanemabe, Doença de Alzheimer e anti-beta-amiloide. Foram incluídos estudos publicados nos últimos 9 anos, em idioma inglês, espanhol ou português, que abordassem a temática. Resultados: O lecanemabe mostrou eficácia consistente na redução das placas de amiloide cerebral, associadas à doença de Alzheimer, além de sugerir benefícios cognitivos e funcionais. Contudo, houve alguns efeitos adversos como infusão relacionada e ocorrência de anormalidades relacionadas à imagem de amiloide. Considerações: O lecanemabe demonstra maior eficácia que o placebo na redução da carga de Aβ em estágios iniciais da DA, com impacto significativo na diminuição das placas amiloides e no retardamento do declínio cognitivo. O fármaco foi bem tolerado, indicando um perfil de segurança aceitável. Contudo, apesar dos resultados promissores, são necessários estudos de longo prazo para avaliar completamente seu perfil de segurança e eficácia.
Strategi Coping Player Mobile Legends Dalam Menghadapi Tindakan Verbal Abuse
Authors: Putri Pillar Emeraldayanti , Oktaviana Mimbar 
Published: September 2024

Penelitian psikologi kualitatif ini memiliki tujuan untuk mengetahui bagaimana (1)bentuk dari perilaku Verbal Abuse yang diterima oleh player laki-laki di Game Mobile Legends (2)dampak dari tindakan Verbal Abuse yang diterima oleh player laki-laki di Mobile Legends, (3) seperti apa strategi coping yang mereka lakukan untuk mengatasi tindakan Verbal Abuse tersebut melalui pendekatan fenomenologi. Data dikumpulkan melalui wawancara semi-terstruktur dengan empat laki-laki player game Mobile Legends:Bang-Bang. Melalui metode IPA (Interpretative Phenomenological Analysis) didapatkan tiga tema induk yakni, pengalaman Verbal Abuse, dampak Verbal Abuse, dan strategi coping. Pada tema pertama dijelaskan bagaimana proses dan bentuk Verbal Abuse yang diterima oleh laki-laki di game Mobile Legends. Tema kedua menjelaskan tentang penurunan performa,kepercayaan diri, dan emosi negatif sebagai dampak dari Verbal Abuse. Tema ketiga menampilkan strategi coping yang dilakukan oleh player laki-laki. Dari studi ini dapat disimpulkan bahwa keempat partisipan dapat mengantarkan permasalahan yang mereka miliki melalui strategi coping.
Pengaruh Tenaga Kerja Terhadap Hasil Produksi Home Industri Kerajinan Cor Kuningan Di Desa Bejijong Kecamatan Trowulan Kabupaten Mojokerto
Authors: Pudjowati Juliani , Wahyuni Susi Tri , Masadah Masadah 
Published: September 2024

Penelitian ini membahas Pengaruh Tenaga Kerja taerhadap hasil produksi Home Industri kerajinan cor kuningan Di Desa Bejijong Kecamatan Trowulan Kabupaten Mojokerto. Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis Pengaruh Tenaga Kerja taerhadap hasil produksi Home Industri kerajinan cor kuningan Di Desa Bejijong Kecamatan Trowulan Kabupaten Mojokerto. Metode yang dipergunakan adalah kuantitatif. Pengumpulan data menggunakan quisioner . Adapun sampel dari penelitian ini berjumlah 125 orang pengrajin industry cor kuningan Di Desa Bejijong.. Adapun variabel dalam penelitian ini terdapat dua varibel yaitu variabel dependent yaitu Hasil produksi (Y) dan variabel independent yaitu Tenaga kerja (X). Sedangkan analisis data menggunakan regresi linier sederhana dengan bantuan software SPSS versi 26. Hasil penelitian Terdapat Pengaruh tenaga kerja Terhadap hasil produksi melalui pengujian hipotesis yaitu t hitung 11,248 > t tabel 1.657 dengan tingkat signifkan 0,000 < 0,05 maka artinya terdapat pengaruh postif yang signifikan antara tenaga Kerja terhadap Hasil produksi Home Industri kerajinan cor kuningan Di Desa Bejijong Kecamatan Trowulan Kabupaten Mojokerto
Pengaruh Budaya Organisasi dan Komitmen Profesional Terhadap Kinerja Pegawai dengan Berbagi Pengetahuan sebagai Pemediasi pada Kantor Pelayanan Pajak Pratama Bukittinggi
Authors: Budiman Rully , Putri Eka Risma 
Published: September 2024

Penelitian ini dilatarbelakangi permasalahan yaitu yang dirasakan pada penerapan budaya organisasi yang kurang optimal dan rendah. Pegawai yang belum komitmen terhadap profesi nya sebagai pegawai pajak dan masih ada yang belum menjalankan profesinya secara maksimal lalu masih ada yang tidak menjalankan kegiatan berbagi pengetahuan dalam menunjang kinerja pegawai dalam menjalankan tugasnya. Jenis penelitian adalah kuantitatif dengan menggunakan pendekatan Partial Least Square dengan model persamaan Structural Equation Modeling. Pengumpulan data dengan kuesioner dan observasi. Populasi berjumlah 108 orang, namun responden penelitian berjumlah 67 orang pegawai yang memiliki kriteria dengan masa tugas diatas lima 5 tahun di kantor pajak dan telah bertugas diatas 2 tahun. Pengujian hipotesis menggunakan program SmartPLS3. Hasil penelitian ini ditemukan bahwa Budaya Organisasi berpengaruh positif dan signifikan terhadap Kinerja Pegawai pada Kantor Pelayanan Pajak Pratama Bukittinggi. Komitmen Profesional berpengaruh negatif dan tidak signifikan terhadap Kinerja Pegawai. Budaya Organisasi berpengaruh positif dan signifikan terhadap Berbagi Pengetahuan. Komitmen Profesional berpengaruh positif dan signifikan terhadap Berbagi Pengetahuan. Berbagi Pengetahuan bernilai positif namun tidak berpengaruh positif dan tidak signifikan terhadap Kinerja Pegawai Kantor Pelayanan Pajak Pratama Bukittinggi. Berbagi Pengetahuan tidak memediasi hubungan Budaya Organisasi terhadap Kinerja Pegawai pada Kantor Pelayanan Pajak Pratama Bukittinggi