bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between skating mechanical capabilities and off‐ice physical abilities of highly trained teenage ice hockey players
Authors: Glaude‐Roy Julien , Ducas Julien , Brunelle Jean‐François , Lemoyne Jean 
Published: September 2024

AbstractThis study examines the associations between force and velocity characteristics of forward skating and off‐ice speed, agility, and power of highly trained teenage ice hockey players. Players attending the Quebec ice hockey federation's off‐season evaluation camp were invited to participate in this study. Final sample consists of 107 highly trained teenage ice hockey players (Males: n = 38; 13.83 ± 0.38 years; Females: n = 69: 14.75 ± 0.90 years). Individual force–velocity profiles (F–V) were determined during a 44 m skating sprint. Off‐ice speed, agility, and power were measured using 30 m sprint, 5‐10‐5 agility, and standing long jump. Associations between F–V mechanical capabilities and off‐ice indicators were analyzed with correlational analyses and multivariate analysis of covariance (MANCOVA). Results of pooled data indicate that the three off‐ice measures had moderate associations with F0 and V0 and large associations with Pmax. Associations with Rfmax, Drf, and Sfv were moderate to small. F0 had stronger associations with off‐ice performance in female players while V0 was more important with male players. MANCOVA identified 5‐10‐5 times as the better predictor for F0 while 30 m sprints times better predicted V0. To maximize physical attributes of skating ability, practitioners are encouraged to focus on a general physical preparation for highly trained teenage players. Prioritizing types of exercises that use change of direction or acceleration and linear speed should have distinct effects on F0 and V0 on the ice.
Nano Silicon Integrated Hard Carbon from Conjugated Microporous Polymer for High‐Efficient Lithium Storage
Authors: Shu Qiqi , Zhang Qingtang , Wu Xiaoyu , Xie Zhimin , Liang Chenli , Xie Zhengwei 
Published: September 2024

AbstractIt is a significant issue to develop silicon/carbon composite anode with high‐capacity and long cycling stability for lithium‐ion batteries. However, the huge volume expansion of silicon during lithiation leads to severe pulverization of silicon, resulting in serious capacity fading over cycles. Herein, nano silicon integrated hard carbon (20Si@HC, 20 wt% nano silicon) is prepared by pyrolyzing nano silicon in‐situ coated a conjugated microporous polymer (CMP). CMP‐derived hard carbon coating features developed porous structure, which not only deliver a high lithium storage capacity, but also provide enough space for the volume expansion of nano silicon. When evaluated as an anode for lithium‐ion batteries, the 20Si@HC delivers an impressive 1037 mAh g−1 at 0.1 A g−1 and a capacity retention ratio of 72.07% for 100 cycles at 0.6 A g−1, providing some reference for designing high‐capacity silicon/carbon composites.
The reverse genetic as a potential of virus‐induced gene silencing in tomato biology
Authors: Tang Qiong , Wei Sishan , Chen Zexun , Zheng Xiaodong , Tu Pengcheng , Tao Fei 
Published: September 2024

AbstractIn the realm of plant genomics, virus‐induced gene silencing (VIGS) technology emerges as a potent tool, employing a reverse genetic strategy to elucidate plant gene functions. Recognized for its simplicity, cost‐effectiveness, and broad applicability, VIGS facilitates the exploration of novel genes in vegetable crops and unveils mechanisms underlying disease resistance and stress response. Moreover, it offers vital support for crop enhancement and molecular breeding. In the context of tomato biology, VIGS holds promise for transformative advancements, spanning from genomics and variety improvement to molecular breeding. This review comprehensively analyzes the pivotal breakthroughs achieved in tomato physiology through global applications of VIGS and explores its strengths and limitations. Future prospects suggest VIGS's pivotal role in reshaping tomato biology, modulating secondary metabolism, and bolstering stress resilience. By delineating diverse applications of VIGS technology, this review fosters innovation in tomato research, opening new vistas for its utilization in plant gene functional analysis.
Quinic acid as an inhibitor of α‐glucosidase activity, nonenzymatic glycosylation, and glucose transport in Caco‐2 cells
Authors: Han Ziyi , Wang Leyu , Sun Panjie , Huang Mengxin , Yu Fei , Liu Junsheng , Wu Yuanyuan , He Puming , Tu Youying , Li Bo 
Published: September 2024

AbstractHyperglycemia and diabetes are common metabolic disorders. It is considered a safe and effective strategy to screen active ingredients from food and herbs for controlling blood sugar levels. Quinic acid (QA) is a natural polyphenolic acid with various health‐promoting properties. In this study, QA was found to exhibit a potent inhibitory effect on α‐glucosidase activity, with a half maximal inhibitory concentration (IC50) of 5.46 mM. This inhibitory property surpassed that of three common organic acids including gallic acid, malic acid, and citric acid. A combination of 25% acarbose (0.5 mM) and 75% QA (5 mM) (v/v) exhibited synergistic inhibition of α‐glucosidase activity. Enzyme kinetics, fluorescence spectra, and molecular docking analyses indicated that QA acted as an uncompetitive inhibitor of α‐glucosidase, with hydrogen bonds playing a key role in the intermolecular interactions. Moreover, QA was found to effectively inhibit three major nonenzymatic glycation products including advanced glycosylation end products (AGEs), fructosamine, and α‐dicarbonyl in a dose‐dependent manner, outperforming the positive control aminoguanidine (AG) within the tested concentration range. Utilizing a Caco‐2 cell model, QA demonstrated the ability to inhibit the transmembrane absorption of glucose. This study highlighted QA as a promising food functional factor that had been overlooked in the past, offering potential benefits in improving hyperglycemia, diabetes, and associated complications through the inhibition of α‐glucosidase, nonenzymatic glycosylation, and glucose uptake.
Sensitivity of Frequency Domain Near Infrared Spectroscopy for Neurovascular Structure Detection in Biotissue Volume: Numerical Modeling Results
Authors: Belsheva Mariia , Safonova Larisa , Shkarubo Alexey 
Published: September 2024

ABSTRACTThrough numerical modeling, it has been determined that near infrared spectroscopy with a frequency domain approach can detect neurovascular structures with diameters from 0.5 mm at source‐detector distances of 5–8 mm, depending on optical parameters and technical implementation of the method. Among the five classical machine learning methods considered, quadratic discriminant analysis is the most effective for detection. Furthermore, it has been demonstrated that the use of a photomultiplier tube and the registration of both amplitude and phase signal components exhibit the highest sensitivity. Spectroscopy can rival modern ultrasound for detecting arterial vessels. A cross‐shaped probe configuration improves sensitivity, and the ratio of reduced scattering coefficient values at different wavelengths is informative for blood‐filled vessel detection. These findings are consistent with and significantly extend previous experimental in vivo and in situ studies and could be valuable for intraoperative diagnostic tasks, particularly in neurosurgery.
The LTAR Cropland Common Experiment at Upper Mississippi River Basin–St. Paul
Authors: Dalzell Brent J. , Baker John M. , Venterea Rodney T. , Spokas Kurt A. , Feyereisen Gary W. , Rice Pamela J. , Alexander Jonathan R. 
Published: September 2024

AbstractThe Soil and Water Management Research Unit of the USDA‐Agricultural Research Service is located in St. Paul, MN, and conducts long‐term research at the University of Minnesota Research and Outreach Center located at Rosemount, MN. As part of USDA's Long‐Term Agroecosystem Research (LTAR) network, the croplands common experiment (CCE) at this location is focused on integration of a kura clover (Trifolium ambiguum M. Bieb.) living mulch (KCLM) system into the prevailing 2‐year rotation of corn (Zea mays L.) and soybean (Glycine max L.) that is typical of the midwestern Corn Belt. The LTAR‐CCE conducted at Rosemount, MN, aims to compare the long‐term environmental and agronomic performance of KCLM while identifying challenges and developing management strategies for this alternative practice. The use of a living mulch for this region is advantageous because, once established, it does not require additional time for fall field operations typically associated with winter cover crops. Results from LTAR‐CCE studies at this site show that KCLM results in a substantial increase in soil field‐saturated hydraulic conductivity and decreases in leaching of nitrate‐nitrogen (NO3−‐N). Disadvantages of the KCLM system include potential for increased emissions of nitrous oxide (N2O) and reduced crop yields, particularly during drought. Also, the optimal approach for crop row establishment in the spring remains uncertain. Ongoing LTAR‐CCE research with KCLM aims to better understand and quantify both benefits and risks across conditions of interannual weather variability and changing climate to develop guidance for suitable adoption and management of this alternative practice.
Mixed autoimmune hemolytic anemia as the initial presentation of systemic lupus erythematosus: A case report and review
Authors: Edwards Brian P. , Senapati Sidhartha Gautam , Kasianchyk Mariia , Shah Joel , Ayvali Fatih , Maharaj Satish 
Published: September 2024

AbstractAutoimmune hemolytic anemia (AIHA) is an acquired condition caused by autoantibody mediated destruction of erythrocytes. AIHA is classified as warm or cold depending on whether the autoantibodies involved react optimally at or below body temperature (37°C), respectively. Mixed AIHA, with features of both, is rare and clinically more severe. We report a case of mixed AIHA that was found to be the presentation of systemic lupus erythematosus (SLE). Treatment with rituximab and prednisone resulted in good response. Although more commonly associated with warm AIHA, SLE can present with mixed AIHA.
Effects of different slaughtering methods on the energy metabolism, apoptosis process and quality of grouper (Epinephelus fuscoguttatus) during cold storage at 4 °C
Authors: Zhao Xin , Xu Zhilong , Liu Yu , Mei Jun , Xie Jing 
Published: September 2024

AbstractBACKGROUNDThe aquatic processing industry is increasingly aware of the need to ensure that slaughtering is carried out under high welfare standards, so there is a need to explore the impact of slaughter methods on fish fillets. This study aimed to investigate the effects of different slaughtering methods (M1, lethality by hammering; M2, gas mixture causing death; M3, lethality by clove oil anesthesia + ice slurry; M4, lethality by ice slurry; M5, lethality by gradient cooling) on the energy metabolism, apoptosis and flesh mass in grouper (Epinephelus fuscoguttatus).RESULTSTherefore, 120 fish (24 per treatment) were slaughtered by the five methods. The results showed that the succinate dehydrogenase (SDH) enzyme activity of M5 sample was higher. The serum glucose level of M2 samples and DAPI staining fluorescence of M2 samples were the highest, indicating that the stress response of M2 was strong. In addition, the texture, pH, total volatile basic nitrogen (TVB‐N), thiobarbituric acid (TBA) and K value results showed M5 samples had better flesh quality.CONCLUSIONGradient cooling lethality had the least effect on oxidative damage and apoptosis in grouper during cold storage as the gradient cooling lethality had the least effect on antioxidant enzyme activities. © 2024 Society of Chemical Industry.
Impact of proton pump inhibitors on pathologic response rates following fluoropyrimidine‐based neoadjuvant chemotherapy in pancreatic cancer patients
Authors: Steadman Jessica A. , Sultan Ahmer , Day Courtney N. , Parish Marie A. , Warner Susanne G. , Kendrick Michael L. , Truty Mark J. , Jin Zhaohui , Thiels Cornelius A. 
Published: September 2024

AbstractBackgroundProton pump inhibitors (PPIs) negatively impact fluoropyrimidine‐based chemotherapy efficacy in colorectal cancer. This study assessed PPI impact on major pathologic response (mPR) rates of pancreatic adenocarcinoma (PDAC) patients receiving fluoropyrimidine‐based chemotherapy.MethodsAn institutional retrospective review of resected PDAC patients receiving neoadjuvant fluoropyrimidine‐based chemotherapy (98% FOLFIRINOX) from 2011 to 2021 was conducted. Outcomes were stratified by use or nonuse of PPIs within 6 months of neoadjuvant chemotherapy initiation. Primary outcome was mPR defined as complete or near complete response.ResultsAmong 540 patients included, the median age was 64 (IQR: 60–70) years, 297 (55%) were male, and 202 (37%) were PPI users. 170 (31%) patients had mPR with similar rates among PPI users and nonusers (29% vs. 33%, p = 0.38). No difference in mPR was seen between PPI users and nonusers receiving chemoradiation (35% vs. 36%, p = 0.89) or ≥8 cycles of NAC (33% vs. 36%, p = 0.55). Median OS for PPI users was 30.9 versus 31.7 months for nonusers (p = 0.62). On multivariable analysis, PPI therapy was not associated with decreased survival.ConclusionPPI usage did not significantly influence mPR or OS following neoadjuvant fluoropyrimidine‐based chemotherapy in resected PDAC patients. Further analysis of all patients, not just those who underwent resection, is required.
Performance of Prenatal Ultrasound Screening for the Relative Positioning of Mesenteric Vessels
Authors: Faure Jean Michel , Larroque‐Devigne Anne , Forgues Dominique , Mousty Eve , Couture Alain , Kalfa Nicolas , Prodhomme Olivier , Fuchs Florent 
Published: September 2024

ObjectivesAbnormal relative positioning of the superior mesenteric artery (SMA) and vein (SMV) can lead to intestinal malrotation that predisposes to midgut volvulus. The aim of this study was to assess the prenatal ultrasound ability to visualize the relative position of SMA and SMV in normal pregnancies.MethodsProspective cohort study performed in Montpellier University Hospital Centre, including 80 fetuses during routine 3rd trimester ultrasound scan. For each fetus included, the relative position of the vessels on an axial image was defined as SMV on the right, forward, or on the left of SMA. Doppler imaging was additionally used if necessary. Data were compared to the neonatal abdominal scans performed by pediatric radiologist.ResultsThe superior mesenteric vessels were identified in 79 fetuses. Prenatal findings showed a usual relative position of the vessels, that is, the vein on the right of the artery, in 96.2%. In 2 cases, the vein was strictly in front of the artery, and in 1 case, the vein was on the left side of the artery. Seventy‐four neonates were examined and comparison with prenatal finding showed a perfect agreement (Kappa coefficient of 100%). An intestinal malrotation was postnatally diagnosed corresponding to the case where vein was on the left side of the artery.ConclusionThis study showed that the relative position of the SMA and SMV could be assessed using ultrasound prenatal examination with a perfect agreement with postnatal findings. In case of abnormal vessels positioning more examinations should be promote including prenatal MRI and postnatal conventional radiologic examinations to confirm intestinal malrotation.
Reversible Addition‐Fragmentation Chain‐Transfer Polymerization in Supercritical CO2: A Review
Authors: Versteeg Friso G. , Picchioni Francesco 
Published: September 2024

AbstractThe development of cleaner, more environmentally friendly processes in polymerization technology is crucial due to the prevalent use of volatile organic solvents (VOCs), which are harmful and toxic. Future regulations are likely to limit or ban VOCs. This review explores the use of supercritical solvents, specifically supercritical CO2 (scCO2), in polymerization processes. The study focuses on reversible addition‐fragmentation chain‐transfer (RAFT) induced homo‐polymerization of various monomers using specific chain transfer agents (CTAs) in scCO2. RAFT polymerization, a reversible deactivation radical polymerization (RDRP) polymerization, relies heavily on the choice of CTA, which significantly influences the dispersity and molar mass of the resulting polymers. Stabilizers are also crucial in controlling product specifications for polymerizations in supercritical CO2, except for fluor‐based polymers, although they must be removed and preferably recycled to ensure product purity and sustainability. The review notes that achieving high molar mass through RAFT polymerization in scCO2 is challenging due to solubility limits, which lead to polymer precipitation. Despite this, RAFT polymerization in scCO2 shows promise for sustainable, circular production of low molar mass polymers, although these cannot yet be fully considered green products.
Proline‐Functionalized Magnetic Nanoparticles as Highly Performing Asymmetric Catalysts
Authors: Álvarez‐Bermúdez Olaia , Landfester Katharina , Zhang Kai A. I. , Muñoz‐Espí Rafael 
Published: September 2024

AbstractAmino acids have a crucial role in the field of asymmetric organocatalysis for the production of chiral compounds with high added value and specific biological activity. In particular, proline offers high activity and stereoselectivity for catalyzing aldol reactions in organic solvents. However, proline‐based catalysts often lack water‐solubility, accessibility, catalytic performance, or recovery in aqueous media. This work reports the design of proline‐functionalized poly(methyl methacrylate) (PMMA) nanoparticles with a magnetic core that offer high availability of chiral units in water and high recyclability. A proline‐based copolymerizable surfactant is designed and integrated onto the surface of PMMA nanoparticles through a miniemulsion polymerization process without using additional surfactants. The miniemulsion technique allows the incorporation of magnetite to the system to create a magnetically separable catalyst. The chiral nanocatalyst presents a high diastereoselective catalytic activity for the intermolecular aldol reaction between p‐nitrobenzaldehyde and cyclohexanone in water.
Adenoid cystic carcinoma: insights from molecular characterization and therapeutic advances
Authors: Jia Yunxuan , Liu Yupeng , Yang Haitang , Yao Feng 
Published: September 2024

AbstractAdenoid cystic carcinoma (ACC) is a malignant tumor primarily originating from the salivary glands, capable of affecting multiple organs. Although ACC typically exhibits slow growth, it is notorious for its propensity for neural invasion, local recurrence, and distant metastasis, making it a particularly challenging cancer to treat. The complexity of ACC's histological and molecular features poses significant challenges to current treatment modalities, which often show limited effectiveness. Recent advancements in single‐cell RNA‐sequencing (scRNA‐seq) have begun to unravel unprecedented insights into the heterogeneity and subpopulation diversity within ACC, revealing distinct cellular phenotypes and origins. This review delves into the intricate pathological and molecular characteristics of ACC, focusing on recent therapeutic advancements. We particularly emphasize the insights gained from scRNA‐seq studies that shed light on the cellular landscape of ACC, underscoring its heterogeneity and pathobiology. Moreover, by integrating analyses from public databases, this review proposes novel perspectives for advancing treatment strategies in ACC. This review contributes to the academic understanding of ACC by proposing novel therapeutic approaches informed by cutting‐edge molecular insights, paving the way for more effective, personalized therapeutic approaches for this challenging malignancy.
Energy stability analysis of MHD flow in a rectangular duct
Authors: Boeck Thomas , Brynjell‐Rahkola Mattias , Duguet Yohann 
Published: September 2024

AbstractWe study the energy stability of pressure‐driven laminar magnetohydrodynamic flow in a rectangular duct in the presence of a transverse homogeneous magnetic field. The walls of the duct are electrically insulating. The quasistatic approximation of the induction equation is used. For sufficiently strong fields, the laminar velocity distribution has a uniform core and convex Hartmann and Shercliff boundary layers on the walls perpendicular and parallel to the magnetic field. The linear eigenvalue problem for the energy Reynolds number depends on the streamwise wavenumber, the Hartmann number, and the aspect ratio. We focus on duct geometries with small aspect ratios in order to compare with stability results from one‐dimensional channel flow. The lift‐up mechanism dominates in the limit of zero streamwise wavenumber and provides a linear dependence between the critical Reynolds and Hartmann number in the duct. For finite streamwise wavenumbers and decreasing aspect ratio, the duct results converge to Orr's original energy stability result for spanwise uniform perturbations to the plane Poiseuille base flow.
Thin porous Ni‐foam enhanced CFRP/Al adhesive joint inserted by ultrasonic vibration
Authors: Zhou Zhengwu , Wang Yongfei , Chen Chao 
Published: September 2024

AbstractTo enhance the mechanical properties of the adhesive layer in joints, a thin–structural open–cell porous Ni–foam was embedded into the adhesive interface through ultrasonics (US) assisted. The porous metal foam is effective in interlocking itself with adhesive. After the ultrasonic vibration was applied for 0.17 s, the adhesive penetrated Ni–foam, generating enough residue. This technique effectively improves the energy absorption and shear strength of the CFRP/Al single lap joint by more than 250.33% and 118.4% with a 0.5 mm thick Ni–foam insert, respectively. The fatigue resistance increased by 154% with a 0.3 mm thick Ni–foam insert based on the fatigue testing results and the Weibull distribution method. The S–N curves were established at different reliabilities for engineering applications. With the Ni–Foam insert, the failure modes were changed through crack deflexion, Ni–Foam degumming, and crack blocking.Highlights
Ultrasonic vibration assisting Ni‐foam inserts CFRP/Al adhesive joints.
The shear strength of joints with Ni‐foam was maximally increased by 118.4%.
The fracture forms of joints with Ni‐foam were changed.
The fatigue life of the joints with Ni‐foam was maximally increased by 154%.
S–N curve of joint with Ni–foam of different reliability levels was got.