bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durable Complete Response After Discontinuation of Pembrolizumab in Patients With Metastatic Melanoma
Authors: Robert Caroline , Ribas Antoni , Hamid Omid , Daud Adil , Wolchok Jedd D. , Joshua Anthony M. , Hwu Wen-Jen , Weber Jeffrey S. , Gangadhar Tara C. , Joseph Richard W. , Dronca Roxana , Patnaik Amita , Zarour Hassane , Kefford Richard , Hersey Peter , Zhang Jin , Anderson James , Diede Scott J. , Ebbinghaus Scot , Hodi F. Stephen 
Published: December 2017

Purpose Pembrolizumab provides durable antitumor activity in metastatic melanoma, including complete response (CR) in about 15% of patients. Data are limited on potential predictors of CR and patient disposition after pembrolizumab discontinuation after CR. We describe baseline characteristics and long-term follow-up in patients who experienced CR with pembrolizumab in the KEYNOTE-001 study ( ClinicalTrials.gov identifier: NCT01295827). Patients and Methods Patients with ipilimumab-naive or -treated advanced/metastatic melanoma received one of three dose regimens of pembrolizumab. Eligible patients who received pembrolizumab for ≥ 6 months and at least two treatments beyond confirmed CR could discontinue therapy. Response was assessed every 12 weeks by central Response Evaluation Criteria in Solid Tumors version 1.1. For this analysis, CR was defined per investigator assessment, immune-related response criteria, and potential predictors of CR were evaluated using univariate and multivariate analyses. Results Of 655 treated patients, 105 (16.0%) achieved CR after median follow-up of 43 months. At data cutoff, 92 patients (87.6%) had CR, with median follow-up of 30 months from first CR. Fourteen (13.3%) patients continued to receive treatment for a median of ≥ 40 months. Pembrolizumab was discontinued by 91 patients (86.7%), including 67 (63.8%) who proceeded to observation without additional anticancer therapy. The 24-month disease-free survival rate from time of CR was 90.9% in all 105 patients with CR and 89.9% in the 67 patients who discontinued pembrolizumab after CR for observation. Tumor size and programmed death-ligand 1 status were among the baseline factors independently associated with CR by univariate analysis. Conclusion Patients with metastatic melanoma can have durable complete remission after discontinuation of pembrolizumab, and the low incidence of relapse after median follow-up of approximately 2 years from discontinuation provides hope for a cure for some patients. The mechanisms underlying durable CR require further investigation.
Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage
Authors: Heinitz Sascha , Basolo Alessio , Piaggi Paolo , Piomelli Daniele , Jumpertz von Schwartzenberg Reiner , Krakoff Jonathan 
Published: December 2017

AbstractContextThe endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), as well as the related acylethanolamide oleoylethanolamide (OEA), have been implicated in energy expenditure (EE) regulation and metabolic diseases. Muscle (fat-free mass) and fat (fat mass) are metabolically active compartments and main determinants of EE.ObjectiveTo assess whether human muscle, adipose, and plasma endocannabinoids correlate with EE.DesignMuscle, adipose, and plasma AEA, 2-AG, and OEA concentrations were measured via liquid chromatography–mass spectrometry. EE was assessed by indirect whole-room calorimetry.SettingClinical trial.ParticipantsObese/overweight Native Americans of full (n = 35) and at least half (n = 21) Southwestern heritage.Main Outcome MeasuresTwenty-four-hour EE, sleeping EE (SLEEP), resting EE (REE), respiratory quotient (RQ), and macronutrient oxidation.ResultsIn full Natives, muscle AEA concentration correlated with SLEEP (r = −0.65, P = 0.004) and REE (r = −0.53, P = 0.02). Muscle 2-AG was associated with SLEEP (r = −0.75, P = 0.0003). Adipose OEA concentration correlated with RQ (r = −0.47, P = 0.04) and lipid oxidation (r = 0.51, P = 0.03). Plasma OEA concentration was associated with SLEEP (r = −0.52, P = 0.04). After adjustment for major determinants, these lipids explained nearly 20% of the additional variance of the respective measure. Similarly, in Native Americans of at least half Southwestern heritage, investigated lipids correlated with EE measures.ConclusionEndocannabinoids in metabolically relevant peripheral tissues explained a large part of EE variation and may be involved in regulating EE. Dysregulation of peripheral endocannabinoids may predispose people to metabolic diseases via an effect on EE and lipid oxidation.
Progesterone-Mediated Inhibition of the GnRH Pulse Generator: Differential Sensitivity as a Function of Sleep Status
Authors: Kim Su Hee , Lundgren Jessica A , Bhabhra Ruchi , Collins Jessicah S , Patrie James T , Burt Solorzano Christine M , Marshall John C , McCartney Christopher R 
Published: December 2017

AbstractContextDuring normal, early puberty, luteinizing hormone (LH) pulse frequency is low while awake but increases during sleep. Mechanisms underlying such changes are unclear, but a small study in early pubertal girls suggested that differential wake-sleep sensitivity to progesterone negative feedback plays a role.ObjectiveTo test the hypothesis that progesterone acutely reduces waking LH pulse frequency more than sleep-associated pulse frequency in late pubertal girls.DesignRandomized, placebo-controlled, double-blinded crossover study.SettingAcademic clinical research unit.ParticipantsEleven normal, postmenarcheal girls, ages 12 to 15 years.InterventionSubjects completed two 18-hour admissions in separate menstrual cycles (cycle days 6 to 11). Frequent blood sampling for LH assessment was performed at 1800 to 1200 hours; sleep was encouraged at 2300 to 0700 hours. Either oral micronized progesterone (0.8 mg/kg/dose) or placebo was given at 0700, 1500, 2300, and 0700 hours, before and during the first admission. A second admission, performed at least 2 months later, was identical to the first except that placebo was exchanged for progesterone or vice versa (treatment crossover).Main Outcome MeasuresLH pulse frequency during waking and sleeping hours.ResultsProgesterone reduced waking LH pulse frequency by 26% (P = 0.019), with no change observed during sleep (P = 0.314). The interaction between treatment condition (progesterone vs placebo) and sleep status (wake vs sleep) was highly significant (P = 0.007).ConclusionsIn late pubertal girls, progesterone acutely reduced waking LH pulse frequency more than sleep-associated pulse frequency. Differential wake-sleep sensitivity to progesterone negative feedback may direct sleep-wake LH pulse frequency changes across puberty.
A 6-Year Follow-Up of Fracture Incidence and Volumetric Bone Mineral Density Development in Girls With Turner Syndrome
Authors: Soucek Ondrej , Schönau Eckhard , Lebl Jan , Willnecker Johannes , Hlavka Zdenek , Sumnik Zdenek 
Published: December 2017

Abstract

Context
Patients with Turner syndrome (TS) are at risk for osteoporotic fractures.

Objective
The aims of this study were to assess the incidence of clinically important fractures in girls with TS and prospectively describe the development of volumetric bone mineral density (BMD).

Design
Peripheral quantitative computerized tomography (pQCT) of the radius every other year over the 6 years of observation.

Setting
Government-funded university referral center.

Participants
Thirty-two girls with TS, aged 6 to 16 years, were included in the analyses. Fracture incidence was compared with the data in the general population. Bone density and strength were compared with data from 185 healthy girls.

Outcomes
The main clinical outcome was the fracture occurrence. The secondary outcomes were the changes in Z-scores of the bone parameters.

Results
Three girls with TS sustained four fractures during 6 years of observation. The fracture rate in TS was not substantially higher than the downward-biased fracture-rate estimate from age-matched, healthy controls (P = 0.48). Whereas the trabecular BMD Z-score decreased with age (β estimate −0.21 ± 0.04, P &lt; 0.001), total bone cross-sectional area correspondingly increased (+0.16 ± 0.04, P &lt; 0.001), which led to normal bone strength. A positive history of incident fractures was not significantly associated with any of the pQCT-derived bone parameters.

Conclusions
Current pediatric TS patients that are treated with growth hormone and estrogens are not at risk for osteoporotic fractures. Low BMD in TS may be counterweighted by enlarged bone radius, which leads to normal bone strength at the appendicular skeleton.
Embryonic Exposure to Dexamethasone Affects Nonneuronal Cells in the Adult Paraventricular Nucleus of the Hypothalamus
Authors: Frahm Krystle A , Handa Robert J , Tobet Stuart A 
Published: December 2017

Abstract
Neurons in the paraventricular nucleus of the hypothalamus (PVN) integrate peripheral signals and coordinate responses that maintain numerous homeostatic functions. An excess of glucocorticoids during fetal development results in long-lasting consequences tied to disrupted PVN development. The PVN contains a distinct neuronal population and a threefold greater vascular density than the surrounding brain regions that prepubertally is reduced in offspring exposed to excess glucocorticoids in utero. This study expands the examination of sex-specific nonneuronal PVN composition by examining astrocytes, astrocytic endfeet, and pericytes. Blood-brain barrier (BBB) competency and composition were examined along with depressive-like behavior and hypothalamic-pituitary-adrenal function in male and female mice. For PVN vasculature, female offspring of vehicle (veh)-treated mothers had significantly more astrocytes and pericytes than male offspring from the same litters. Female offspring from dexamethasone (dex)-treated mothers had significantly lower levels of astrocytes than female offspring from veh-treated mothers, whereas male offspring from dex-treated mothers had greater levels of pericytes compared with veh-treated male offspring. Using the tail-suspension test, male and female offspring from dex-treated mothers had significantly shorter latencies to immobility, indicating an increase in depression-like behavior, and showed greater plasma corticosterone after restraint stress, which was significantly greater in female offspring from dex-treated mothers even after recovery. Therefore, in addition to long-term sex differences in cellular components of the BBB in the PVN that were differentially regulated by fetal glucocorticoid exposure, there were behavioral differences observed into early adulthood in a sex-specific manner.
Clinical Utility of Intraoperative Motor-Evoked Potential Monitoring to Prevent Postoperative Spinal Cord Injury in Thoracic and Thoracoabdominal Aneurysm Repair: An Audit of the Japanese Association of Spinal Cord Protection in Aortic Surgery Database
Authors: Yoshitani Kenji , Masui Kenichi , Kawaguchi Masahiko , Kawamata Mikito , Kakinohana Manabu , Kato Shinya , Hasuwa Kyoko , Yamakage Michiaki , Yoshikawa Yusuke , Nishiwaki Kimitoshi , Aoyama Tadashi , Inagaki Yoshimi , Yamasaki Kazumasa , Matsumoto Mishiya , Ishida Kazuyoshi , Yamashita Atsuo , Seo Katsuhiro , Kakumoto Shinichi , Hayashi Hironobu , Tanaka Yuu , Tanaka Satoshi , Ishida Takashi , Uchino Hiroyuki , Kakinuma Takayasu , Yamada Yoshitsugu , Mori Yoshiteru , Izumi Shunsuke , Nishimura Kunihiro , Nakai Michikazu , Ohnishi Yoshihiko 
Published: December 2017

BACKGROUND:
Spinal cord ischemic injury is the most devastating sequela of descending and thoracoabdominal aortic surgery. Motor-evoked potentials (MEPs) have been used to intraoperatively assess motor tract function, but it remains unclear whether MEP monitoring can decrease the incidence of postoperative motor deficits. Therefore, we reviewed multicenter medical records of patients who had undergone descending and thoracoabdominal aortic repair (both open surgery and endovascular repair) to assess the association of MEP monitoring with postoperative motor deficits.

METHODS:
Patients included in the study underwent descending or thoracoabdominal aortic repair at 12 hospitals belonging to the Japanese Association of Spinal Cord Protection in Aortic Surgery between 2000 and 2013. Using multivariable mixed-effects logistic regression analysis, we investigated whether intraoperative MEP monitoring was associated with postoperative motor deficits at discharge after open and endovascular aortic repair.

RESULTS:
We reviewed data from 1214 patients (open surgery, 601 [49.5%]; endovascular repair, 613 [50.5%]). MEP monitoring was performed in 631 patients and not performed in the remaining 583 patients. Postoperative motor deficits were observed in 75 (6.2%) patients at discharge. Multivariable logistic regression analysis revealed that postoperative motor deficits at discharge did not have a significant association with MEP monitoring (adjusted odds ratio [OR], 1.13; 95% confidence interval [CI], 0.69–1.88; P = .624), but with other factors: history of neural deficits (adjusted OR, 6.08; 95% CI, 3.10–11.91; P < .001), spinal drainage (adjusted OR, 2.14; 95% CI, 1.32–3.47; P = .002), and endovascular procedure (adjusted OR, 0.45; 95% CI, 0.27–0.76; P = .003). The sensitivity and specificity of MEP <25% of control value for motor deficits at discharge were 37.8% (95% CI, 26.5%–49.5%) and 95.5% (95% CI, 94.7%–96.4%), respectively.

CONCLUSIONS:
MEP monitoring was not significantly associated with motor deficits at discharge.
The first transcriptomes from field-collected individual whiteflies (Bemisia tabaci, Hemiptera: Aleyrodidae)
Authors: Sseruwagi Peter , Wainaina James , Ndunguru Joseph , Tumuhimbise Robooni , Tairo Fred , Guo Jian-Yang , Vrielink Alice , Blythe Amanda , Kinene Tonny , De Marchi Bruno , Kehoe Monica A. , Tanz Sandra , Boykin Laura M. 
Published: December 2017

Background: Bemisia tabaci species (B. tabaci), or whiteflies, are the world’s most devastating insect pests. They cause billions of dollars (US) of damage each year, and are leaving farmers in the developing world food insecure. Currently, all publically available transcriptome data for B. tabaci are generated from pooled samples, which can lead to high heterozygosity and skewed representation of the genetic diversity. The ability to extract enough RNA from a single whitefly has remained elusive due to their small size and technological limitations. Methods: In this study, we optimised the single whitefly RNA extraction procedure, and sequenced the transcriptome of four individual adult Sub-Saharan Africa (SSA1) B. tabaci. Transcriptome sequencing resulted in 39-42 million raw reads. De novo assembly of trimmed reads yielded between 65,000-162,000 transcripts across B. tabaci transcriptomes. Results: Bayesian phylogenetic analysis of mitochondrion cytochrome I oxidase (mtCOI) grouped the four whiteflies within the SSA1 clade. BLASTn searches on the four transcriptomes identified five endosymbionts; the primary endosymbiont Portiera aleyrodidarum and four secondary endosymbionts: Arsenophonus, Wolbachia, Rickettsia, and Cardinium spp. that were predominant across all four SSA1 B. tabaci samples with prevalence levels between 54.1-75%. Amino acid alignments of the NusG gene of P. aleyrodidarum for the SSA1 B. tabaci transcriptomes of samples WF2 and WF2b revealed an eleven amino acid residue deletion that was absent in samples WF1 and WF2a. Comparison of the protein structure of the NusG protein from P. aleyrodidarum in SSA1 with known NusG structures showed the deletion resulted in a shorter D loop. Conclusions: The use of field-collected specimens means time and money will be saved in future studies using single whitefly transcriptomes in monitoring vector and viral interactions. Our method is applicable to any small organism where RNA quantity has limited transcriptome studies.
Use of Promogran to treat venous leg ulcers
Authors: Barrett Simon A , Moore Keith 
Published: December 2017

Based on the outcome of a series of symposia, this series aims to answer the question, ‘what is compromised wound healing and how do we increase our understanding of chronic wounds?’ Ultimately, we hope to explore the feasibility of developing a chronicity predictor. Many venous leg ulcers fail to heal when treated with compression and dressings that simply create a moist wound environment. Promogran is designed not only to produce a moist wound environment but also to inhibit protease activity, counteract a pro-oxidant environment, protect growth factors and modulate fibroblast activity. In two case reports concerning hard-to-heal venous leg ulcers, use of Promogran resulted in reduced exudation and stimulation of healing. Clinical observations found with these ulcers were consistent with Promogran's proposed mode of action
Ocho apellidos vascos and the poetics of post-ETA Spain
Authors: Miguélez-Carballeira Helena 
Published: December 2017

Abstract
The article takes as a starting point the idea that the ceasefire announced by ETA (Euskadi Ta Askatasuna) in October 2011 has allowed for the appearance of newly inflected cultural engagements with the legacies of the Basque-Spanish violent conflict. Among these, the blockbuster Ocho apellidos vascos (OAV) is without a doubt the most significant exponent of a post-ETA poetics that engages with the present memory wars on the Basque-Spanish conflict from a state-aligned perspective on consensus. This perspective is characterized by the use of soft metaphors related to (heteronormative) romantic or familial love as a way of condensing the complexities of Spain’s internal national conflicts; the privileging of individual forms of memorialization over collective ones; the fetishization of affects such as forgiveness; and the erasure of politics and history. After an analysis of how these strategies play out in OAV and its sequel Ocho apellidos catalanes (OAC) (Martínez Lázaro, 2015), the article places these films in relation to a larger corpus of statealigned post-ETA cultural products comprising, for example, the repenting ex-ETA member Iñaki Rekarte’s autobiography, published in 2015. By way of contrast, the article proposes that other post-ETA cultural products such as Ion Arretxe’s memoirs Intxaurrondo: la sombra de un nogal (2015a), the art exhibition Todo lo demás (Katakrak, Iruña-Pamplona, 2016) and recent Basque-language literature disrupt the narratives and metaphors of state-aligned consensus on the legacies of the Basque-Spanish conflict.
The evaluation of the effectiveness of diet therapy for obese patients basing on studying of the polymorphism rs9939609 of the FTO gene
Authors: Lapik Irina A. , Gapparova Kamila M. , Sorokina Elena Y. , Grigorian Olga N. 
Published: December 2017

The Aim. The aim of the study was to develop and evaluate the effectiveness of dietary therapy in obese patients on the basis of studying the polymorphism rs9939609 of the FTO gene.
Materials and methods. 100 patients with obesity of I-III degree aged from 18 to 55 years were examined. All patients underwent genotyping using allele-specific amplification with real-time detection of results. Depending on the genotypes of the FTO gene, obese patients received different diet therapy and were divided into 3 groups: patients with the TT and AT genotype received a standard low-calorie diet, and with the AA genotype a personalized diet.
Results. It was found that a decrease in the caloric content of the diet contributed to a decrease in body weight in obese patients, mainly due to muscle mass in carriers of the genotype AT, and in carriers of genotypes TT and AA - mainly due to the fat component.
Conclusions. Thus, the carriers of the mutant allele A in the homozygous and heterozygous variant require the selection of only a personalized diet. Therefore, in the appointment of dietary therapy to obese patients, it is recommended to carry out molecular genetic studies that will not only identify individuals with increased need for personalization of dietary therapy, but also increase the effectiveness of treatment for obesity and prevent the development of its complications.
Discusión: La enseñanza del cine
Authors: Filippelli Rafael , Oubiña David , Wolf Sergio , Hevia Hernán , Falco Agustín , Deré Pedro 
Published: December 2017

Esta mesa de Discusión sobre La enseñanza del cine se realizó en el Encuentro de Cine Documental 2016, donde también se exhibió At Berkeley, de Frederick Wiseman.
Libro "Santa Fe: Ciudad Set", de Sergio Peralta
Authors: Peralta Sergio , Gerbaudo Analía , Beceyro Raúl 
Published: December 2017

El 30 de marzo de 2017 se presentó el libro Santa Fe: Ciudad Set, de Sergio Peralta, editado por Grupo de Cine y Universidad Nacional del Litoral, participando su autor Sergio Peralta, su prologuista Analía Gerbaudo y Raúl Beceyro.
Dispositivos de libertad en los espacios marginales del río de la plata. El caso de corrientes en la primera mitad del siglo XIX
Authors: VALENZUELA FÁTIMA 
Published: December 2017

El presente trabajo se insertar en las Discusiones historiográficas actuales sobre el abolicionismo en el Río de la Plata, a partir de un diálogo con la literatura existente sobre la materia. A estos efectos, se analiza el recorrido gestado en Corrientes atendiendo a las respuestas localistas generadas en este espacio en torno a la supresión de la esclavitud, esto es, el proceso iniciado en 1830 a partir de la aparición de estatutos internos que legislaron la condición del liberto, que continuó con las disposiciones que pusieron fin a la esclavitud en el contexto bélico de 1839 - 1842 . El abordaje aspira a contribuir a la historiografía local existente en Corrientes sobre los esclavizados y libres; y busca explorar un período clave en la construcción de los estados provinciales como fue la primera mitad del siglo XIX.
Determinants of Television Media Libraries’ Use, Collections, and Services among the Television Media Professionals in Bengaluru
Authors: Kumara Prasanna , Divyananda K. 
Published: December 2017

The purpose of this study is to examine the utilisation of television media libraries use, resources and services among the media professional working in various television channels at Bengaluru. Based on this background, a survey method has been adopted and well-structured questionnaire was distributed to collect relevant data about usage behaviour by the media professionals. The study covers media professional working at various television media in Bengaluru. Data was collected from 1132 media professionals and final results indicate that minimum usage of the television media libraries is observed in respondents. The overall statistics shows that usage, collections and services of television media libraries as somehow satisfactory. It is found that primary purpose of the media library is archival and not for referral. An effort has been made by the authors to study the ways to accomplish the demands of television media professionals in television media of Bengaluru, Karnataka.