bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional difference in sulcal infolding progression correlated with cerebral cortical expansion in cynomolgus monkey fetuses
Authors: Sawada Kazuhiko , Fukunishi Katsuhiro , Kashima Masatoshi , Imai Noritaka , Saito Shigeyoshi , Aoki Ichio , Fukui Yoshihiro 
Published: January 2017

AbstractThe present study aimed to specify the cerebral sulci developed by cortical expansion in cynomolgus monkey fetuses. The degree of sulcal infolding was evaluated by the gyrification index (GI), which was quantified using ex vivo magnetic resonance imaging. The correlation of cortical volume with the sulcal GI was most frequent during embryonic days (EDs) 100 to 120. Interestingly, the high correlation was marked during EDs 140 to 150 in restricted primary sulci in prefrontal, parietotemporal and medial temporal regions. The present results suggest that cortical expansion is involved in gyral demarcation by sulcal infolding, followed by the sulcal infolding progression in phylogenetically‐newer cortices.
Cannabis use and dating violence among college students: A call for research
Authors: Shorey Ryan C. , Haynes Ellen , Strauss Catherine , Temple Jeff R. , Stuart Gregory L. 
Published: January 2017

AbstractDating violence is a serious and prevalent problem on college campuses. Although there is a robust literature documenting that alcohol use is consistently associated with increased risk for perpetrating dating violence, little research has examined the role of cannabis in dating violence perpetration. With increasing legalisation of cannabis throughout the world, it is imperative to understand what role, if any, cannabis may play in the important public health problem of dating violence. In this commentary, we discuss the current state of the research on cannabis and dating violence and suggest avenues for additional research in this area. It is critical that we conduct methodologically sound research on the association between cannabis and dating violence so that we can understand what role, if any, cannabis exerts on this important problem. [Shorey RC, Haynes E, Strauss C, Temple JR, Stuart GL. Cannabis use and dating violence among college students: A call for research. Drug Alcohol Rev 2017;36:17–19]
Stability of alcohol use and teen dating violence for female youth: A latent transition analysis
Authors: Choi Hye Jeong , Elmquist JoAnna , Shorey Ryan C. , Rothman Emily F. , Stuart Gregory L. , Temple Jeff R. 
Published: January 2017

AbstractIntroduction and AimsAlcohol use is one of the most widely accepted and studied risk factors for teen dating violence (TDV). Too little research has explored longitudinally if it is true that an adolescent's alcohol use and TDV involvement simultaneously occur. In the current study, we examined whether there were latent status based on past‐year TDV and alcohol use and whether female adolescents changed their statuses of TDV and alcohol use over time.MethodsThe sample consisted of 583 female youths in seven public high schools in Texas. Three waves of longitudinal data collected from 2011 to 2013 were utilised in this study. Participants completed self‐report assessments of alcohol use (past‐year alcohol use, number of drinks in the past month and episodic heavy drinking within the past month) and psychological and physical TDV victimisation and perpetration. Latent transition analysis was used to examine if the latent status based on TDV and alcohol use changed over time.ResultsFive separate latent statuses were identified: (i) no violence, no alcohol; (ii) alcohol; (iii) psychological violence, no alcohol; (iv) psychological violence, alcohol; and (v) physical and psychological violence, alcohol. Latent transition analysis indicated that adolescents generally remained in the same subgroup across time.DiscussionThis study provides evidence on the co‐occurrence of alcohol use and teen dating violence, and whether teens' status based on dating violence and alcohol use are stable over time. Findings from the current study highlight the importance of targeting both TDV and substance use in intervention and prevention programs. [Choi HJ, Elmquist J, Shorey RC, Rothman EF, Stuart GL,Temple JR. Stability of alcohol use and teen dating violence for female youth: Alatent transition analysis. Drug Alcohol Rev 2017;36:80–87]
Application of the CRISPR gene‐editing technique in insect functional genome studies – a review
Authors: Cui Yubao , Sun Jin‐Lu , Yu LiLi 
Published: January 2017

AbstractThe clustered regularly interspaced short palindromic repeats (CRISPR) structural family form an acquired immune system in bacteria that is able to degrade invading virus or phage DNA. The CRISPR/Cas system has been co‐opted as an RNA‐mediated nuclease for use in targeted genome engineering. The CRISPR/Cas system provides a novel tool for manipulating genomic DNA using an approach that is simple, convenient, and easy to learn. Since its first description as a genome editor in 2012, it has been widely applied to bacteria, yeast, nematodes, flies, zebrafish, mice, rats, and human cells. This review describes the basic principles of the system and its application. In particular, we focus on CRISPR as a tool to manipulate and study the functional genomes of the planet's most abundant organisms, insects, which have diverse impacts on humans and the environment.
Aromatic plants affect the selection of host tomato plants by Bemisia tabaci biotype B
Authors: Carvalho Mateus Gimenez , Bortolotto Orcial Ceolin , Ventura Maurício Ursi 
Published: January 2017

AbstractThe effects of intercropping aromatic plants (AP) on behavior and population development of Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) were investigated in the field (adults) and in the greenhouse (nymphs). The responses of adults to the volatiles of tomato, Solanum lycopersicum L. (Solanaceae), plants plus AP [T + coriander (Co), rue (R), marigold (M), Greek basil (B), or citronella (Ci)] vs. humidified air or tomato volatiles only were assessed in laboratory Y‐tube olfactometer assays. We found higher responses of adult B. tabaci to the humidified air than to the T + Co, T + B, and T + Ci treatments. The responses to T + R and T + M were similar to those to the humidified air. Responses to tomato volatiles were also greater than to T + Co, T + B, and T + Ci. In field assays, populations of adult insects were evaluated in tomato alone, in tomato intercropped with coriander or Greek basil, and in tomato mulched with citronella grass for 6 weeks. Adult whiteflies were generally found in greater numbers in the tomato‐alone treatment compared to tomato intercropped with coriander or basil and tomato with citronella grass mulch. Reduction in adult whitefly populations compared to the population found in tomato alone was 84, 79, and 69% in intercrops of T + Co and T + B, and the tomato with citronella mulch treatment, respectively. Infestations of B. tabaci nymphs in plots of tomato plants cultivated alone or intercropped with reseeded coriander plants were also determined in a greenhouse. Nymph counts in the greenhouse assay were generally lower in tomato intercropped with coriander than in tomato alone for all six assessments. The mean reduction in nymphs in tomato intercropped with coriander was 37.7% compared with tomato alone. These results indicate that intercropping aromatic plants reduces infestations of B. tabaci.
Diversity, spatial distribution, and sampling for ant management decision‐making in integrated pest management programs in citrus groves
Authors: Martínez‐Ferrer María Teresa , Campos‐Rivela José Miguel 
Published: January 2017

AbstractAnts play important ecological roles, such as predation on other arthropods, seed dispersal, and soil structure maintenance. In citrus agroecosystems, ants are considered a secondary pest. The damage they cause is indirect through the disruption of the biological control of pests, especially honeydew producers. In integrated pest management programs, adequate and precise sampling methods are required to accurately determine the need for chemical ant control to minimize the economic and environmental costs of unnecessary chemical treatments and to reduce the risk of crop loss by pests. In Mediterranean citrus groves, eight ant species that differed in abundance and frequency have been found foraging on citrus trees: Lasius grandis Forel, Pheidole pallidula (Nylander), Plagiolepis pygmaea (Latreille), Formica gerardi Bondroit, Formica rufibarbis Fabricius, Camponotus sylvaticus (Olivier), Linepithema humile (Mayr), and Tapinoma erraticum (Latreille) (all Hymenoptera: Formicidae). The trunk was selected as the most efficient sampling unit to establish the monitoring method. Aggregation indices on the trunk of these species were calculated, and enumerative and binomial sampling methods were developed for the most frequent species, L. grandis and Ph. pallidula. Ant species differed in spatial distributions within citrus orchards, and required different sample sizes to estimate population abundance. The minimum sample size required, taking into account the maximum average abundance found – 44.1 L. humile, 17.3 L. grandis, and 3.5 Ph. pallidula per trunk per min –, would be 28, 25, and 54 trees, respectively.
Optimising irradiation dose in mass‐produced Queensland fruit fly, Bactrocera tryoni, for sterile insect release: the incorporation of residual effects on F1 progeny
Authors: Bloomfield C.I.A. , Fanson B.G. , Mirrington R. , Gillespie P.S. , Dominiak B.C. 
Published: January 2017

AbstractThe sterile insect technique (SIT) is a potential tool for the management and eradication of incursions of Queensland fruit fly, Bactrocera tryoni (Froggatt) (Diptera: Tephritidae). Mass‐produced B. tryoni are irradiated during the pupal stage to induce reproductive sterility. As increasing irradiation dosage results in declining fly quality, determining the lowest possible dosage that induces sufficient reproductive sterility is of particular interest. However, in calculating reproductive sterility, previous research has not considered carryover irradiation effects to F1 progeny. To test for these effects, B. tryoni pupae were exposed to one of five target dose ranges: 0, 20–25, 40–45, 60–65, or 70–75 Gy. Upon adult eclosure, fly quality was assessed using standard quality control (QC) measures: adult eclosure rates, flight ability, sex ratio, and longevity under nutritional stress. No effect of irradiation dose on any of the QC measures was found. Residual fertility was assessed by measuring larval eclosure failure for all doses. For the 0–45 Gy doses, mortality was measured during development of F1 progeny and larval eclosure rates were measured in F2 progeny. For irradiated females, irradiation dose significantly affected egg production, as well as increasing mortality during pupation of F1 progeny. For irradiated males, irradiation dose strongly affected larval eclosure of F1 progeny and, similar to females, mortality increased during pupation with higher doses. Our results suggest that residual effects of irradiation dose decreases F1 progeny viability and current estimates of residual fertility for B. tryoni underestimate the actual residual fertility. We conclude by synthesising our results with the previous findings and we propose that the target irradiation dose for B. tryoni may be lowered to 55–60 Gy.
Characterizing spring emergence of adult Halyomorpha halys using experimental overwintering shelters and commercial pheromone traps
Authors: Bergh J. Christopher , Morrison William R. , Joseph Shimat V. , Leskey Tracy C. 
Published: January 2017

AbstractTo improve our understanding of adult Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) overwintering biology and to better inform models of its population dynamics, its temporal pattern of spring emergence was investigated using experimental overwintering shelters in screened cages within protective structures. In 2012, plastic shelters containing 100 adults were deployed in unheated, unlighted buildings, and adjacent woodlots in Virginia, USA. In 2013 and 2014, wooden shelters containing 300 paint‐marked adults were deployed in pairs in six woodlots across Virginia, West Virginia, and Maryland, USA; one in a closed cage and one in a cage with the top removed, enabling emerged adults to be counted or to disperse, respectively. In 2013 and 2014, pheromone‐baited and non‐baited pyramid traps encircled the shelters at each site. Regular counts of adults that emerged into the closed cage and of marked and ‘wild’ (unmarked) adults captured in traps were conducted from February or March through early July. In 2012, emergence patterns from shelters in buildings and woodlots were very similar and matched those recorded from woodlots in 2013 and 2014. In all years, a small peak of emergence occurred in about mid‐April, a larger and more prolonged peak was observed between mid‐May and early June, and emergence ended by early July. Of the 449 H. halys adults captured in traps between 2013 and 2014, only three were marked individuals from shelters in the open cage, suggesting that adults emerging from overwintering sites may require a dispersal flight before responding to pheromone‐baited traps. In 2013 and 2014, respectively, 98 and 93% of captures were in pheromone‐baited traps, but there was no correlation between the weekly number of adults that emerged from shelters in the closed cages and captures in traps.
Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction
Authors: Beuke Katharina , Schildberg Frank A. , Pinna Federico , Albrecht Ute , Liebe Roman , Bissinger Michaela , Schirmacher Peter , Dooley Steven , Bode Johannes G. , Knolle Percy A. , Kummer Ursula , Breuhahn Kai , Sahle Sven 
Published: January 2017

Gut‐derived bacterial lipopolysaccharides (LPS) stimulate the secretion of tumour necrosis factor (TNF) from liver macrophages (MCs), liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs), which control the acute phase response in hepatocytes through activation of the NF‐κB pathway. The individual and cooperative impact of nonparenchymal cells on this clinically relevant response has not been analysed in detail due to technical limitations. To gain an integrative view on this complex inter‐ and intracellular communication, we combined a multiscale mathematical model with quantitative, time‐resolved experimental data of different primary murine liver cell types. We established a computational model for TNF‐induced NF‐κB signalling in hepatocytes, accurately describing dose‐responsiveness for physiologically relevant cytokine concentrations. TNF secretion profiles were quantitatively measured for all nonparenchymal cell types upon LPS stimulation. This novel approach allowed the analysis of individual and collective paracrine TNF‐mediated NF‐κB induction in hepatocytes, revealing strongest effects of MCs and LSECs on hepatocellular NF‐κB signalling. Simulations suggest that both cell types act together to maximize the NF‐κB pathway response induced by low LPS concentrations (0.1 and 1 ng/mL). Higher LPS concentrations (≥ 5 ng/mL) induced sufficient TNF levels from MCs or LSECs to induce a strong and nonadjustable pathway response. Importantly, these simulations also revealed that the initial cytokine secretion (1–2 h after stimulation) rather than final TNF level (10 h after stimulation) defines the hepatocellular NF‐κB response. This raises the question whether the current experimental standard of single high‐dose cytokine administration is suitable to mimic in vivo cytokine exposure.DatabaseThe computational models described in this manuscript are available in the JWS database via the following link: https://jjj.bio.vu.nl/database/beuke
Motivation, opportunity, and ability: Understanding new habits and changes adopted for weight management
Authors: Willmott Taylor , Parkinson Joy 
Published: January 2017

AbstractAs obesity rates continue to rise, both effective prevention and treatment programs are urgently required. Combating obesity requires weight management programs that are accessible and scalable to large numbers of people. There is growing evidence that commercial programs, which combine behavior change techniques with the key motivators for changing habits, are effective as the first line in helping people adopt healthier dietary and activity patterns. In particular, digital programs have the potential to provide a service to large numbers of people, be widely accessible and cost effective for the individual. However, to date, digital programs have been relatively under‐utilized and under‐evaluated. There is little published evidence on the performance of programs on a large scale, outside of partnerships with primary care, where participants self‐refer and pay a nominal fee. The purpose of the following study was to examine the interrelated effect of motivation, opportunity, and ability on the behavioral outcomes of a digital commercial weight management program. To address this aim, a thematic content analysis of participants' qualitative responses to habits learned and changes adopted was conducted. Findings reveal that habits learned and changes adopted as a result of participating in the program influence not only weight loss outcomes but other health and well‐being outcomes as well.
Intralesional immunotherapy compared to cryotherapy in the treatment of warts
Authors: Khozeimeh Fahime , Jabbari Azad Farahzad , Mahboubi Oskouei Yaghoub , Jafari Majid , Tehranian Shahrzad , Alizadehsani Roohallah , Layegh Pouran 
Published: January 2017

AbstractBackgroundWarts are the most common clinical manifestation of the human papilloma‐virus infection in the skin and mucous membranes. In spite of the various therapeutic modalities for nongenital skin warts, there is still no single method to be used as an approved treatment. In this study, we compared the efficacy of immunotherapy and cryotherapy on wart lesions.MethodsSixty patients with verruca vulgaris and plantar warts were randomly divided into two groups. One group received intralesional injection of candida antigen repeated every 3 weeks until complete improvement of all warts or for a maximum of three sessions. The second group was treated by cryotherapy with liquid nitrogen for a maximum of ten sessions or until clearance of all lesions. T‐test and chi‐square test were used for statistical analysis, and P < 0.05 was considered statistically significant.ResultsThe patients showed a significant therapeutic response to immunotherapy compared to cryotherapy (P = 0.023). Moreover, a significant difference was observed between the time‐elapsed before treatment and the therapeutic response between both groups (P = 0.041). 76.7% of patients were completely cured with immunotherapy, while only 56.7% responded to cryotherapy. Complete remission was observed with fewer sessions (20.17 ± 0.65) in immunotherapy compared to cryotherapy (3.82 ± 2.481), but no statistically significant difference was shown between groups. Immunotherapy was well‐tolerated except for the pain during injection that was the most common side effect.ConclusionsIntralesional immunotherapy is an effective treatment of warts. This method has a better therapeutic response, needs fewer sessions, and is capable of treating distant warts.
Retinoic acid‐inducible gene I (RIG‐I)‐like receptors (RLRs) in fish: current knowledge and future perspectives
Authors: Chen Shan Nan , Zou Peng Fei , Nie Pin 
Published: January 2017

SummaryRetinoic acid‐inducible gene I (RIG‐I) ‐like receptors (RLRs) are found conservatively present in teleost fish. All three members, RIG‐I, MDA5 and LGP2, together with the downstream molecules such as MITA, TRAF3 and TBK1, have been identified in a range of fish species. However, it is unexpected that RIG‐I has not been reported in fish of Acanthopterygii, and it would be important to clarify the presence and role of the RIG‐I gene in a broad range of taxa in Teleostei. RLRs in fish can be induced in vivo and in vitro by viral pathogens as well as synthetic dsRNA, poly(I:C), leading to the production of type I interferons (IFNs) and the expression of IFN‐stimulated genes (ISGs). Bacterial pathogens, such as Edwardsiella tarda, and their components, such as lipopolysaccharide are also found to induce the expression of RLRs, and whether such induction was mediated through the direct recognition by RLRs or through crosstalk with other pattern recognition receptors recognizing directly bacterial pathogen‐associated molecular patterns awaits to be investigated. On the other hand, RLR‐activated type I IFN production can be negatively regulated in fish by molecules, such as TBK‐1‐like protein and IRF10, which are found to negatively regulate RIG‐I and MAVS‐activated type I IFN production, and to block MITA or bind ISRE motifs, respectively. It is considered that the evolutionary occurrence of RLRs in fish, and their recognized ligands, especially those from their fish pathogens, as well as the mechanisms involved in the RLR signalling pathways, are of significant interest for further investigation.
TIGIT signalling pathway negatively regulates CD4+ T‐cell responses in systemic lupus erythematosus
Authors: Mao Lie , Hou Hongyan , Wu Shiji , Zhou Yu , Wang Juan , Yu Jing , Wu Xiaohui , Lu Yanfang , Mao Liyan , Bosco Munyemana Jean , Wang Feng , Sun Ziyong 
Published: January 2017

SummaryB‐lymphocyte hyperactivity in systemic lupus erythematosus (SLE) is T‐cell‐dependent, and CD4+ T‐cell activation is essential to SLE pathogenesis. However, the mechanism of the deregulation of CD4+ T cells in SLE is largely unknown. T‐cell immunoglobulin and ITIM domain (TIGIT) is a new inhibitory receptor preferentially expressed on activated CD4+ T cells. Here, we address the role of TIGIT in the pathogenesis of SLE. Our results showed that TIGIT expression on CD4+ T cells was significantly elevated in patients with SLE and highly correlated with the activity of the disease. TIGIT+ CD4+ T cells from both healthy individuals and patients with SLE had a more activated phenotype than TIGIT− CD4+ T cells. In contrast, the activation, proliferation and cytokine production potential of TIGIT+ CD4+ T cells were significantly lower than those of TIGIT− CD4+ T cells. Furthermore, activation of the TIGIT pathway by using CD155 could substantially down‐regulate the activities of CD4+ T cells from SLE patients in vitro, and in vivo administration of CD155 resulted in a delayed development of SLE in MRL/lpr mice. TIGIT is a powerful negative regulator of CD4+ T cells in SLE, which suggests that the TIGIT signalling pathway may be used as a potential therapeutic target for treating this disease.