bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mission Theology Revisited: Keeping up with the Crises
Authors: Frazier William B. 
Published: January 2016

Maryknoll, the Catholic Foreign Mission Society of America, holds its General Chapter, or assembly, every six years. This is a gathering of leaders and delegates, representing Maryknoll Missioners from around the world, to reflect on the affairs and concerns of the society. The General Chapter provides a prime occasion for reflecting on missional principles and reassessing priorities. In preparation for the most recent chapter, held in late 1984, Father William B. Frazier, M.M., Professor of Systematic Theology at Maryknoll School of Theology, Maryknoll, New York, prepared a painstaking and comprehensive study entitled “Mission Theology Revisited.” Although this was prepared as an “in-house” document to help fellow Maryknollers clarify their thinking about fundamental issues Maryknoll has been confronting in recent years, the society and Father Frazier have kindly agreed to share the study with the readers of the International Bulletin. Two decades ago Frazier captured the attention of missiologists when, in the aftermath of Vatican Council II, he published “Guidelines for a New Theology of Mission” (Worldmission 18, No. 4, Winter 1967–68; reprinted in Gerald H. Anderson and Thomas F. Stransky, eds., Mission Trends No. 1 [1974]). In the current study, he analyzes the tension—and the implications far mission theory and practice—between those missioners who retain a more or less traditional focus on the evangelization of persons and those who wish to emphasize the “evangelization” of societal institutions and systemic structures. Although lengthy and at times occupied with developments particular to Maryknoll, Frazier's study, we believe, makes a major contribution toward explicating the current missiological debate and ferment. Few, if any, of today's mission agencies—Protestant or Catholic—can hope to remain aloof from the dynamics of the issues he discusses. Testimony to the seriousness of the situation and the debate is found in the reflections of three mission leaders invited by the editors to respond to Father Frazier's study. Their responses appear following Frazier's article below.
Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation
Authors: Estevez Brian , Kim Kyungho , Delaney M. Keegan , Stojanovic-Terpo Aleksandra , Shen Bo , Ruan Changgeng , Cho Jaehyung , Ruggeri Zaverio M. , Du Xiaoping 
Published: January 2016

Key PointsGPIb-IX signaling cooperates with PAR signaling to promote platelet response to low concentrations of thrombin, which are important in vivo. Thrombin induces a GPIb-IX–specific signaling pathway that requires the cytoplasmic domain of GPIbα, 14-3-3 protein, Rac1, and LIMK1.
Adipose-derived endothelial and mesenchymal stem cells enhance vascular network formation on three-dimensional constructs in vitro
Authors: Freiman Alina , Shandalov Yulia , Rozenfeld Dekel , Shor Erez , Segal Sofia , Ben-David Dror , Meretzki Shai , Egozi Dana , Levenberg Shulamit 
Published: January 2016

Abstract
Background
Adipose-derived mesenchymal stem cells (MSCs) have been gaining fame mainly due to their vast clinical potential, simple isolation methods and minimal donor site morbidity. Adipose-derived MSCs and microvascular endothelial cells have been shown to bear angiogenic and vasculogenic capabilities. We hypothesized that co-culture of human adipose-derived MSCs with human adipose-derived microvascular endothelial cells (HAMECs) will serve as an effective cell pair to induce angiogenesis and vessel-like network formation in three-dimensional scaffolds in vitro.

Methods
HAMECs or human umbilical vein endothelial cells (HUVECs) were co-cultured on scaffolds with either MSCs or human neonatal dermal fibroblasts. Cells were immunofluorescently stained within the scaffolds at different time points post-seeding. Various analyses were performed to determine vessel length, complexity and degree of maturity.

Results
The HAMEC:MSC combination yielded the most organized and complex vascular elements within scaffolds, and in the shortest period of time, when compared to the other tested cell combinations. These differences were manifested by higher network complexity, more tube alignment and higher α-smooth muscle actin expression. Moreover, these generated microvessels further matured and developed during the 14-day incubation period within the three-dimensional microenvironment.

Conclusions
These data demonstrate optimal vascular network formation upon co-culture of microvascular endothelial cells and adipose-derived MSCs in vitro and constitute a significant step in appreciation of the potential of microvascular endothelial cells and MSCs in different tissue engineering applications that can also be advantageous in in vivo studies.
Detection of hepatic maturation by Raman spectroscopy in mesenchymal stromal cells undergoing hepatic differentiation
Authors: Wu Hao-Hsiang , Ho Jennifer H. , Lee Oscar K. 
Published: January 2016

Abstract
Introduction
Mesenchymal stromal cells (MSCs) are well known for their application potential in tissue engineering. We previously reported that MSCs are able to differentiate into hepatocytes in vitro. However, conventional methods for estimating the maturation of hepatic differentiation require relatively large amounts of cell samples. Raman spectroscopy (RS), a photonic tool for acquisition of cell spectra by inelastic scattering, has been recently used as a label-free single-cell detector for biological applications including phenotypic changes and differentiation of cells and diagnosis. In this study, RS is used to real-time monitor the maturation of hepatic differentiation in live MSCs.

Methods
The MSCs were cultured on the type I collagen pre-coating substrate and differentiated into hepatocytes in vitro using a two-step protocol. The Raman spectra at different time points are acquired in the range 400–3000 cm–1and analyzed by quantification methods and principle component analysis during hepatic differentiation from the MSCs.

Results
The intensity of the broad band in the range 2800–3000 cm–1 reflects the amount of glycogen within lipochrome in differentiated hepatocytes. A high correlation coefficient between the glycogen amount and hepatic maturation was exhibited. Moreover, principle component analysis of the Raman spectra from 400 to 3000 cm–1 indicated that MSC-derived hepatocytes were close to the primary hepatocytes and were distinct from the undifferentiated MSCs.

Conclusions
In summary, RS can serve as a rapid, non-invasive, real-time and label-free biosensor and reflects changes in live cell components during hepatic differentiation. The use of RS may thus facilitate the detection of hepatic differentiation and maturation in stem cells. Such an approach may substantially improve the feasibility as well as shorten the time required compared to the conventional molecular biology methods.
Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells
Authors: Leibacher Johannes , Henschler Reinhard 
Published: January 2016

AbstractMesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. They were found to be potent in situations such as tissue repair or severe inflammation. Still, data are lacking with regard to the biodistribution of MSCs, their cellular or molecular target structures, and the mechanisms by which MSCs reach these targets. This review discusses current hypotheses for how MSCs can reach tissue sites. Both preclinical and clinical studies using MSCs applied intravenously or intra-arterially are discussed in the context of our current understanding of how MSCs might work in physiological and pathological situations.
Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma
Authors: Cheng Caixia , Cui Heyang , Zhang Ling , Jia Zhiwu , Song Bin , Wang Fang , Li Yaoping , Liu Jing , Kong Pengzhou , Shi Ruyi , Bi Yanghui , Yang Bin , Wang Juan , Zhao Zhenxiang , Zhang Yanyan , Hu Xiaoling , Yang Jie , He Chanting , Zhao Zhiping , Wang Jinfen , Xi Yanfeng , Xu Enwei , Li Guodong , Guo Shiping , Chen Yunqing , Yang Xiaofeng , Chen Xing , Liang Jianfang , Guo Jiansheng , Cheng Xiaolong , Wang Chuangui , Zhan Qimin , Cui Yongping 
Published: January 2016

Abstract

Background
Esophageal squamous cell carcinoma (ESCC) is the sixth most lethal cancer worldwide and the fourth most lethal cancer in China. Genomic characterization of tumors, particularly those of different stages, is likely to reveal additional oncogenic mechanisms. Although copy number alterations and somatic point mutations associated with the development of ESCC have been identified by array-based technologies and genome-wide studies, the genomic characterization of ESCCs from different stages of the disease has not been explored. Here, we have performed either whole-genome sequencing or whole-exome sequencing on 51 stage I and 53 stage III ESCC patients to characterize the genomic alterations that occur during the various clinical stages of ESCC, and further validated these changes in 36 atypical hyperplasia samples.

Results
Recurrent somatic amplifications at 8q were found to be enriched in stage I tumors and the deletions of 4p-q and 5q were particularly identified in stage III tumors. In particular, the FAM84B gene was amplified and overexpressed in preclinical and ESCC tumors. Knockdown of FAM84B in ESCC cell lines significantly reduced in vitro cell growth, migration and invasion. Although the cancer-associated genes TP53, PIK3CA, CDKN2A and their pathways showed no significant difference between stage I and stage III tumors, we identified and validated a prevalence of mutations in NOTCH1 and in the NOTCH pathway that indicate that they are involved in the preclinical and early stages of ESCC.

Conclusions
Our results suggest that FAM84B and the NOTCH pathway are involved in the progression of ESCC and may be potential diagnostic targets for ESCC susceptibility.
Differences in cancer stage, treatment and in-hospital mortality
between patients with and without schizophrenia: retrospective matched-pair
cohort study
Authors: Ishikawa Hanako , Yasunaga Hideo , Matsui Hiroki , Fushimi Kiyohide , Kawakami Norito 
Published: January 2016

BackgroundHealthcare access and outcomes in cancer patients with schizophrenia
remain unclear.AimsTo investigate the likelihood of early diagnosis and treatment in
patients with schizophrenia who have cancer and their prognosis.MethodA retrospective matched-pair cohort of gastrointestinal cancer patients
was identified using a national in-patient database in Japan.
Multivariable ordinal/binary logistic regressions was modelled to compare
cancer stage at admission, invasive treatments and 30-day in-hospital
mortality between patients with schizophrenia (n = 2495)
and those without psychiatric disorders (n = 9980).ResultsThe case group had a higher proportion of stage IV cancer (33.9%
v. 18.1%), a lower proportion of invasive treatment
(56.5% v. 70.2%, odds ratio (OR) = 0.77, 95% CI
0.69–0.85) and higher in-hospital mortality (4.2% v.
1.8%, OR = 1.35, 95% CI 1.04–1.75).ConclusionsPatients with schizophrenia who had gastrointestinal cancer had more
advanced cancer, a lower likelihood of invasive treatment and higher
in-hospital mortality than those without psychiatric disorders.
ACTH overexpressing pituitary hyperplasia in a patient with ectopic ACTH-syndrome due to carcinoid of the lung
Authors: Dzeranova Larisa Konstantinovna , Skuridina Darya Viktorovna , Voronkova Iya Aleksandrovna , Rozhinskaya Lyudmila Yakovlevna , Manchenko Oksana VLadimirovna , Ablitsov Yuriy Alekseevich , Ablitsov Aleksey Yur'evich , Bolevich Stefani Sergeevna , Grigor'ev Andrey Yur'evich , Pigarova Ekaterina Aleksandrovna , Ankvab Maisna Konstantinova 
Published: January 2016

Ectopic ACTH-syndrome is the most diagnostically challenging variant of endogenous hypercortisolism. Particularly difficult differential diagnosis of this syndrome is from Cushing's disease (CD), as currently there is no single test sufficiently accurate to differentiate accurately ectopic ACTH production from the pituitary. The main functional tests are based on the fact that the vast majority of ectopic ACTH production is autonomous and suppresses one from pituitary. But in some cases this is not observed, and then the data obtained all necessary laboratory and instrumental research evidence in favor of central genesis of CD in a patient with ACTH ectopic secretion, which can lead to inappropriate treatment. If you confirm the ectopic ACTH-syndrome, it may take quite a long time of searching for the pathological focus, as there is no sufficiently precise imaging and diagnostic method for determining the localization of ectopic source of ACTH production. Thus, the differential diagnosis of ACTH-dependent hypercortisolism and localization of the ectopic tumor is the cornerstone of early and radical treatment of patients. We present a difficult clinical case of a patient having a pituitary hyperplasia with excessive ACTH expression with primary ectopic ACTH syndrome caused by lung carcinoid.
Scuttle fly infestation in deteriorating fluid-preserved specimens (Diptera: Phoridae: Megaselia scalaris)
Authors: Pocklington Kate 
Published: January 2016

Abstract
An infestation of scuttle flies, Megaselia scalaris (Loew, 1866), was found in deteriorating 19th century fluid-preserved specimens contained in a glass tank in the Vertebrate Spirit Store at Oxford University Museum of Natural History. A test showed ethanol levels were inadequate to maintain specimen preservation, and a vast amount of fluid had evaporated, leaving the specimens exposed and in a state of decomposition. The conditions provided a suitable habitat for the infestation and subsequent reproduction of M. scalaris. Here, I provide a method for the removal of M. scalaris from infested museum collections, as well as notes on their behavior and the conditions that promote fly infestation. Remedial salvage of the specimen that involves refixation, staging, and final preservation in 75% industrial methylated spirits (IMS/H2O) is described.
Conservation of a museum megamouth shark specimen by changing its preservative from aqueous ethanol to aqueous glycerol
Authors: MacLeod Ian Donald 
Published: January 2016

Abstract
The Western Australian Museum’s iconic 5.2-m megamouth shark (Megachasma pelagios) was relocated 20 km from Perth to the Maritime Museum in Fremantle for treatment in an exhibition gallery. A 70% ethanol solution was diluted to 16% before the glass lids of the fiberglass tank were removed to facilitate removal of the heavy shark. A custom-made stainless steel storage and exhibition tank containing 8,000 L of 30% glycerol solution was prepared inside the exhibition space prior to the arrival of the specimen. Portholes in the top sections provided access points to record the density of the solution using a digital densitometer. The density fell linearly with the logarithm of the immersion time. Equilibration was achieved after the solution showed no change in density for a period of 2 months. To increase the glycerol concentration, 2,000 L of the solution were decanted into storage tanks before the same volume of pure glycerol was added. This process was repeated four times to reach a final level of 62% during the 2.5-year conservation program. The color and flexibility of the shark improved and dehydration wrinkles from ethanol storage were significantly reduced.
Do cosmetic products which are prevent sweating cause breast cancer?<p>Terlemeyi önleyen kozmetik ürünler meme kanserine mi neden oluyor?
Authors: Güler Demir Sevil , Bulut Hülya 
Published: January 2016

<p>Today, underarm and antiperspirant deodorants are extensively consumed cosmetic products in order to prevent sweating. Increasing use of these products is revived the claims of increasing of breast cancer risk. While discussing these claims, drawn attention at society, in the popular press and on the Internet, it has begun to discuss in the scientific literature at the same time. There are academic studies which are shown the relation between underarm cosmetic products and breast cancer as well as the opposites. In this article, literature about whether there is relationship between underarm cosmetic products and breast cancer is reviewed and obtained findings are explained. </p><p> </p><p><strong>Özet</strong></p><p>Günümüzde koltuk altı ve antiperspirant deodorantlar terlemeyi önlemek amacıyla yaygın olarak kullanılan kozmetik ürünlerdir. Bu ürünlerin kullanımının artması, özellikle meme kanseri riskini arttırdığı iddialarını gündeme getirmiştir. Toplumun ilgisini de çeken bu iddialar popüler basın ve internet üzerinde tartışılırken, aynı zamanda bilimsel literatürde de tartışılmaya başlamıştır. Literatürde koltuk altı kozmetik ürünlerle meme kanseri arasında ilişki olduğunu belirten çalışmaların yanı sıra ilişki olmadığını gösteren çalışmalarda yer almaktadır. Bu makalede, koltuk altı kozmetik ürünlerle meme kanseri arasında ilişki olup olmadığına ilişkin literatür taranmış ve elde edilen bulgular açıklanmıştır.</p>
Alienation and anger relation in educational organizations (Şişli Technical and Industrıal Vhs)<p>Eğitim örgütlerinde yabancılaşma ve öfke ilişkisi (Şişli Teknik ve Eml)
Authors: Boz Mehmet , Garipağaoğlu Burçak Çağla 
Published: January 2016

<p>This research aimed to determine the correlation of anger and alienation in educational organizations on the basis of perceptions of teachers. Data was collected from 146 teachers who worked in Şişli Vocational High School, İstanbul. The research was a correlational study which had a quality of relationship survey model. In order to collect the data necessary for the research, 'The work alienation scale ' by Elma ( 2003) and 'The scale of constant anger and anger expressions styles' which was prepared by Spielberger (1998) and translated and adapted by Ozer ( 1994) were conducted. The research results indicated that there was meaningful, medium level, positive sided correlation between the dimensions of work alienation and constant anger level with the dimensions of inward anger among the teachers. It was also found that there was meaningful, positive sided, low level correlation between the dimensions of work alienation and constant anger management level. However, there was not found any meaningful correlation between the dimensions of outward anger and work alienation. Besides, the research results showed that teachers feel alienation mostly in terms of school alienation and from the anger expression styles, they used anger control most frequently.</p><p> </p><p><strong>Özet</strong></p><p>Bu çalışmanın amacı; öğretmenlerin işe yabancılaşma düzeyleri ile sürekli öfke ve öfke ifade tarzları arasında anlamlı bir ilişki olup olmadığını tespit etmektir. Şişli Teknik ve Endüstri Meslek Lisesi’nde görev yapan 146 öğretmen üzerinde yapılan araştırma, nicel verilere dayalı, ilişkisel tarama modeli niteliğinde, korelasyonel bir çalışmadır. Araştırmada Elma (2003) tarafından hazırlanan “Öğretmen İşe Yabancılaşma Ölçeği” ve Spielberger (1988) tarafından geliştirilip, Özer (1994) tarafından çevirisi ve uyarlaması yapılan “Sürekli Öfke ve Öfke İfade Tarzı Ölçeği” kullanılmıştır. Araştırma sonucunda; öğretmenlerde, işe yabancılaşma ile sürekli öfke düzeyi ve öfke içte alt boyutu arasında, orta düzeyde, pozitif yönlü, anlamlı ilişki tespit edilmiştir. İşe yabancılaşma ile öfke kontrol alt boyutu arasında düşük düzeyde, pozitif yönlü, anlamlı ilişki tespit edilmiş, öfke dışta alt boyutu arasında ise anlamlı ilişki tespit edilememiştir. Ayrıca, öğretmenlerin yabancılaşma duygusunu, en çok okula yabancılaşma boyutunda yaşadığı ve öfke ifade tarzlarından, en sık öfke kontrolünü kullandıkları tespit edilmiştir.</p>
On the optimal control problem for two regions’ macroeconomic model
Authors: Surkov Platon G. 
Published: January 2016

Abstract
In this paper we consider a model of joint economic growth of two regions. This model bases on the classical Kobb-Douglas function and is described by a nonlinear system of differential equations. The interaction between regions is carried out by changing the balance of trade. The optimal control problem for this system is posed and the Pontryagin maximum principle is used for analysis the problem. The maximized functional represents the global welfare of regions. The numeric solution of the optimal control problem for particular regions is found. The used parameters was obtained from the basic scenario of the MERGE
Pinning synchronization of two general complex networks with periodically intermittent control
Authors: Meng Fanyu , Wen Bohui , Zhao Mo , Bao Weichuan 
Published: January 2016

AbstractIn this paper, the method of periodically pinning intermittent control is introduced to solve the problem of outer synchronization between two complex networks. Based on the Lyapunov stability theory, differential inequality method and adaptive technique, some simple synchronous criteria have been derived analytically. At last, both the theoretical and numerical analysis illustrate the effectiveness of the proposed control methodology. This method not only reduces the conservatism of control gain but also saves the cost of production.These advantages make this method having a large application scope in the real production process.
Selected Problems Of Transmission Wear Of The Mi-24 Helicopter
Authors: Gębura Andrzej , Zientalski Krzysztof 
Published: January 2016

AbstractThe hypothesis of mutual, destructive impact of the worn upper bearing of the WR-24 transmission on the Mi-24 helicopter's gearbox was stated. The Mi-24 is the only helicopter operated in Poland, in which the gearbox is mounted outside the main transmission – in the centre of the transmission shaft, between the main gearbox and the tail rotor. Damage to the gears in the gearbox of power generators is equivalent to termination of the tail rotor's drive. Such a termination immediately causes rotation of the body in the direction opposite to the direction of rotation of the main rotor. It is associated with the loss of lift and steering. It may lead to a disaster. Such an incident occurred in January 2011 in Afghanistan – both authors participated in its investigation. The authors, taking into account very good, almost legendary combat properties of the Mi-24, and their research of the specifics of wear and tear of the transmission elements, they think that, first, funds for development and implementation of the drive unit monitoring system should be made available specially for this helicopter. For this purpose, the authors propose to use the FAM-C method. It is characterised with significant ergonomics. Thank to this, multiple kinematic pairs can be observed simultaneously, and, therefore, the relationships between them as well.