bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Simple Probe to Smart Composites: Water‐Soluble Pincer Complex With Multi‐Stimuli‐Responsive Luminescent Behaviors
Authors: Duan Lixin , Zheng Qingshu , Liang Yanlin , Tu Tao 
Published: September 2024

AbstractWater‐soluble smart materials with multi‐stimuli‐responsiveness and ultra‐long room‐temperature phosphorescence (RTP) have garnered broad attention. Herein, a water‐soluble terpyridine zinc complex (MeO‐Tpy‐Zn‐OAc), featuring a simple donor‐π‐acceptor (D‐π‐A) structure is presented, which responds to a variety of stimuli, including changes in solvents, pH, temperature, and the addition of amino acids. Notably, MeO‐Tpy‐Zn‐OAc functions as a fluorescence probe, capable of visually and selectively discriminating aspartate or histidine among other common amino acids in water. Additionally, when incorporated into polyvinyl alcohol (PVA) to form the composite MeO‐Tpy‐Zn‐OAc@PVA, the material exhibits reversible writing, photochromism, and a prolonged RTP with a 14 s afterglow. These unique properties enable the composite to be utilized in potential applications such as secure data encryption and inkless printing.
4D Printing Hybrid Soft Robots Enabled by Shape‐Transformable Liquid Metal Nanoparticles
Authors: Huang Xumin , Zhang Liwen , Hang Jiangyu , Quinn Thomas , Nasar Naufal Kabir Ahamed , Lin Yiliang , Hu Chenyang , Pang Xuan , Chen Xuesi , Davis Thomas P. , Qiao Ruirui 
Published: September 2024

AbstractIn recent years, soft robotics has emerged as a rapidly expanding frontier research field that draws inspiration from the locomotion mechanisms of soft‐bodied creatures in nature to achieve smooth and complex motion for diverse applications. However, the fabrication of soft robots with hybrid structures remains challenging due to limitations in material selection and the complex, multi‐step processes involved in traditional manufacturing methods. Herein, a novel direct one‐step additive manufacturing (3D printing) approach is introduced for the fabrication of hybrid robots composed of soft and rigid components for sophisticated tasks. Inspired by the shape‐transformable liquid metal nanoparticles (LMNPs), a functional material toolkit with tuneable mechanical properties and deformability is developed by integrating differently shaped gallium‐based nanoparticles (GNPs) into the 3D printing polymers. Then the direct printing of assembled or one‐piece hybrid soft‐rigid robots is presented through a single recipe of GNPs‐integrated inks. This fabrication method enables precise control of the mechanical properties and shape memory properties within the hybrid structures of robot body with a customized structure design. Their capabilities are further demonstrated through the design and fabrication of hybrid robots as high‐precision gripper, bioinspired motor, and hand rehabilitation device.
WS2 Moiré Superlattices Supporting Au Nanoclusters and Isolated Ru to Boost Hydrogen Production
Authors: Chen Dechao , Gao Tianyu , Wei Zengxi , Wang Mengjia , Ma Yingfei , Xiao Dongdong , Cao Changsheng , Lee Cheng‐You , Liu Pan , Wang Dengchao , Zhao Shuangliang , Wang Hsiao‐Tsu , Han Lili 
Published: September 2024

AbstractMaximizing the catalytic activity of single‐atom and nanocluster catalysts through the modulation of the interaction between these components and the corresponding supports is crucial but challenging. Herein, guided by theoretical calculations, a nanoporous bilayer WS2 Moiré superlattices (MSLs) supported Au nanoclusters (NCs) adjacent to Ru single atoms (SAs) (Ru1/Aun‐2LWS2) is developed for alkaline hydrogen evolution reaction (HER) for the first time. Theoretical analysis suggests that the induced robust electronic metal–support interaction effect in Ru1/Aun‐2LWS2 is prone to promote the charge redistribution among Ru SAs, Au NCs, and WS2 MSLs support, which is beneficial to reduce the energy barrier for water adsorption and thus promoting the subsequent H2 formation. As feedback, the well‐designed Ru1/Aun‐2LWS2 electrocatalyst exhibits outstanding HER performance with high activity (η10 = 19 mV), low Tafel slope (35 mV dec−1), and excellent long‐term stability. Further, in situ, experimental studies reveal that the reconstruction of Ru SAs/NCs with S vacancies in Ru1/Aun‐2LWS2 structure acts as the main catalytically active center, while high‐valence Au NCs are responsible for activating and stabilizing Ru sites to prevent the dissolution and deactivation of active sites. This work offers guidelines for the rational design of high‐performance atomic‐scale electrocatalysts.
Deep‐Learning‐Assisted Triboelectric Whisker Sensor Array for Real‐Time Motion Sensing of Unmanned Underwater Vehicle
Authors: Liu Bo , Dong Bowen , Jin Hao , Zhu Peng , Mu Zhaoyang , Li Yuanzheng , Liu Jianhua , Meng Zhaochen , Zhou Xinyue , Xu Peng , Xu Minyi 
Published: September 2024

AbstractAquatic animals can perceive their surrounding flow fields through highly evolved sensory systems. For instance, a seal whisker array understands the hydrodynamic field that allows seals to forage and navigate in dark environments. In this work, a deep learning‐assisted underwater triboelectric whisker sensor array (TWSA) is designed for the 3D motion estimation and near‐field perception of unmanned underwater vehicles. Each sensor comprises a high aspect ratio elliptical whisker shaft, four sensing units at the root of the elliptical whisker shaft, and a flexible corrugated joint simulating the skin on the cheek surface of aquatic animals. The TWSA effectively identifies flow velocity and direction in the 3D underwater environments and exhibits a rapid response time of 19 ms, a high sensitivity of 0.2V/ms−1, and a signal‐to‐noise ratio of 58 dB. The device also locks onto the frequency of the upstream wake vortex, achieving a minimal detection accuracy of 81.2%. Moreover, when integrated with an unmanned underwater vehicle, the TWSA can estimate 3D trajectories assisted by a trained deep learning model, with a root mean square error of ≈0.02. Thus, the TWSA‐based assisted perception holds immense potential for enhancing unmanned underwater vehicle near‐field perception and navigation capabilities across a wide range of applications.
Plasma‐Generated Luminescent Coatings: Innovations in Thermal Sensitivity and Corrosion Resistance
Authors: Wang Ziyao , Wang Baochen , Yang Xinyao , Li Hui , Mi Ruiyu , Liu Yangai 
Published: September 2024

AbstractThe strategic design of traditional coating materials has long been pivotal in broadening their range of applications. In this work, europium‐doped TiO2 coatings are grown in situ on the surface of titanium substrate using plasma electrolytic oxidation technology. The core reaction took no more than five minutes. Incorporating europium into the coating preserved the inherent corrosion resistance of PEO coatings while imparting anticipated thermal‐sensitive luminescence capabilities. The intrinsic emission of TiO2 and the characteristic emission of Eu3+ (5D0 → 7F2) are employed as the self‐reference for the LIR thermometry. The absolute and relative temperature sensitivity of the coating reached 0.0087 K−1 and 0.739% K−1, respectively. Notably, the coating exhibited a signal discriminability of up to 5100 cm−1 and a temperature uncertainty of only 0.18 K, which is comparable to some TiO2: Eu nanoparticles. The ingenious fusion of corrosion resistance and thermal‐sensitive luminescence of the coating not only makes it a classic protective structure but also facilitates its applicability to diverse scenarios, including optical thermometry in extreme environments.
Supporting companies dealing with asbestos risk: Practical tools for occupational health services, risk prevention specialists, and companies
Authors: Monnerais Isabelle , Loizeau Mireille 
Published: September 2024

AbstractAlthough asbestos has been officially banned in France for over two decades, it remains a major public health and occupational health issue. In 2012, French asbestos regulations became considerably more stringent and complex. Consequently, French Public Works and Building Trades Prevention Organisation (OPPBTP) and occupational health services have been working together for several years to support construction professionals. This support involves information, training and advice. This article presents the range of tools developed by OPPBTP and occupational health services to better understand the asbestos risk as it affects construction companies. These tools and this partnership have demonstrated positive results in confronting risk and in the implementation of suitable means of prevention. They serve the best interests of employees, companies and clients, by combining safeguards to employees' health and worksite performance.
Craniotubular Dysplasia Ikegawa Type: Further Delineation of the Phenotype
Authors: van Ommeren Babeth , Hoekstra Maud , van Gassen Koen , van Jaarsveld Richard , van Haaften Gijs , Mathijssen Irene , Dammers Ruben , van Veelen Marie‐Lise , Baars Rolanda , Giltay Jacques C. 
Published: September 2024

ABSTRACTCraniotubular Dysplasia Ikegawa type is a sclerosing bone disorder recently identified in five patients from four independent Indian families. It is caused by homozygous or compound heterozygous mutations in TMEM53. Deficient TMEM53 leads to overactive BMP signaling which promotes bone formation. Here, we present another three siblings with intronic mutations in TMEM53, identified by exome sequencing, from a Caucasian family. All three siblings displayed skeletal and radiographic features, similar to the earlier described individuals. All our patients had additional features such as cardiac and urogenital anomalies. Our results confirm the phenotype of CTDI. We discuss whether the additional features in our patients are separate from CTDI or reflect a broader spectrum of the syndrome.
A cost utility analysis for the management of acute exacerbations of chronic rhinosinusitis
Authors: Chu Matthew M. , Garcia Jack T. , Sedaghat Ahmad R. , Scangas George A. , Phillips Katie M. 
Published: September 2024

AbstractBackgroundThe management of acute exacerbations of chronic rhinosinusitis (AECRS) is understudied and the most cost‐effective management of AECRS has not been previously investigated. The aim of this study is to determine the most cost‐effective strategy for the initial management of AECRS.MethodsThe study design consisted of a decision‐tree economic model comparing three different initial strategies for managing a patient perceived AECRS: observation, upfront rescue medications, or clinic visit with diagnostic nasal endoscopy (DNE). The primary study outcome was the disease burden of a single AECRS, which was determined by the health utility value and the duration of symptoms. Strategies with an incremental cost‐effectiveness ratio < $50,000/quality‐adjusted life year (QALY) or equivalently < $137/quality‐adjusted life day (QALD) were considered cost‐effective.ResultsObservation was the most cost‐effective strategy at a willingness to pay of $137 per QALD. One‐way sensitivity analysis demonstrated that observation was more effective than upfront rescue medications when the probability of bacterial infection as the cause of AECRS was <24.0%. Upfront rescue medications wer more cost effective than observation when the probability of bacterial infection exceeded 49.0%. Clinic visit with DNE was the most effective strategy to manage an AECRS, but it was not considered cost‐effective.ConclusionObservation is the most cost‐effective strategy for the initial management of AECRS when there is a low likelihood of bacterial infection. When the probability of bacterial etiology of AECRS exceeds 49.0%, upfront rescue medications proved to be the most cost‐effective strategy.
Unraveling the Potential of Mononuclear Zn(II) and Cu(II) Schiff Base Metal Complexes: Microwave‐Aided Synthesis, Theoretical Analysis and Application in Biomimetic Catalysis, CT‐DNA Interaction, and In Vitro Biological Assays
Authors: Paul Sneha , Sanjurani Thangjam , Talukdar Jyotirmoy , Barman Pranjit , Das Ankita , Pandey Piyush 
Published: September 2024

ABSTRACTGiven the widespread and diverse effects of transition metal ions such as copper and zinc in multiple biological processes, this research endeavor addresses herein the microwave‐aided synthesis of two novel tetradentate ONNO (L1) and tridentate NNO (L2) donor Schiff base ligands derived from 4,5‐dimethyl‐1,2‐phenylenediamine and 4‐bromo‐2‐hydroxybenzaldehyde in a 1:2 ratio and from 4,5‐dimethyl‐1,2‐phenylenediamine and 5‐methoxy‐2‐hydroxybenzaldehyde in a 1:1 ratio, with their respective zinc, ZnL1(1) and ZnL2(3), and copper, CuL1(2) and CuL2(4), Schiff base metal complexes, which are comprehensively characterized utilizing physiochemical and analytical techniques, along with geometry optimization using the DFT approach. Spectrophotometric analyses have been used to assess the biomimetic activity in the conversion of 3,5‐DTBC to 3,5‐DTBQ with turnover numbers 53.4 and 78 h−1 in methanol for 2 and 4, whereas the zinc complexes are found to be ineffective. With CT‐DNA, possible modes of interaction with the synthesized complexes have been explored using absorption spectroscopy, where the associated binding constants ranged between 1.541 × 105 and 2.186 × 105 M−1. EtBr‐bound DNA was used in the fluorescence quenching experiments with Stern–Volmer constant (Ksv) values in the range 4.084 × 104 and 3.402 × 104 M−1, showing a stronger association with CT‐DNA. The compounds' ability to inhibit bacterial strains was also examined in vitro, as well as their ability to reduce inflammation, through the protein denaturation method and the DPPH assay for antioxidant activity have been performed. Furthermore, molecular docking simulations have been carried out to obtain a deeper comprehension of the molecular‐level interactions with CT‐DNA and cyclooxygenase‐2 (COX‐2).
Estimating the activation energy of crystallization in blends of poly L‐lactic acid and poly(propylene 2,5‐furan dicarboxylate) during isothermal melt crystallization using temperature dependent infrared spectroscopy
Authors: Sharma Reeha , Lata Roselyn , Patel Tejesvi , Bikiaris Dimitrios N. , Kuboyama Keiichi , Rohindra David 
Published: September 2024

AbstractBlends of Poly‐L‐Lactic Acid (PLLA) and Poly(propylene‐2,5‐furan dicarboxylate) (PPF) which have similar thermal properties were prepared by melt‐mixing. The crystalline/crystalline blends were investigated by Differential Scanning Calorimetry, Polarized Optical Microscopy, Wide Angle X‐Ray Diffraction and temperature dependent Fourier Transform Infrared Spectroscopy. The presence of two glass transition temperatures (Tg) in the blends confirmed immiscibility. The X‐Ray diffraction pattern ruled out the formation of new crystal morphology. PLLA formed large negative birefringent spherulites while PPF spherulites were extremely small. The isothermal crystallization kinetics of the two polyesters in the blends were investigated by monitoring the absorbance intensities of the crystalline infrared bands at 711 cm−1 and 990 cm−1 for PLLA and PPF respectively. Both neat polyesters exhibited a slower crystallization rate, but their behavior varied in the blends. The activation energy (Ea) of crystallization of PLLA and PPF calculated using the Arrhenius equation were −96.58 and −148.59 kJmol−1 respectively. The Ea of both polyesters increased as the content of PLLA in the blends increased. Temperature dependent FTIR was successful in determining the crystallization parameters in crystalline/crystalline blends of PLLA and PPF.
Efficacy and Safety of Intravenous Secukinumab in Patients With Active Axial Spondyloarthritis: Results From a Randomized, Placebo‐Controlled, Phase 3 Study
Authors: Deodhar Atul , Supronik Jerzy , Kivitz Alan , Valenzuela Guillermo , Kapur Karen , Rohrer Susanne , Dokoupilová Eva , Richards Hanno B. , Pavelka Karel 
Published: September 2024

ObjectiveOur goal was to assess the efficacy and safety of intravenous (IV) secukinumab for the treatment of adults with active axial spondyloarthritis (axSpA) in INVIGORATE‐1.MethodsINVIGORATE‐1 (NCT04156620) was a randomized, double‐blind, parallel‐group, phase 3 trial in patients with active axSpA (either radiographic or nonradiographic). Patients were randomized one to one to receive IV secukinumab (6 mg/kg at baseline followed by 3 mg/kg every four weeks) or IV placebo for 16 weeks. After week 16, patients randomized to placebo were switched to IV secukinumab (3 mg/kg every four weeks), and patients randomized to secukinumab continued treatment through week 52. The primary endpoint was the Assessment of SpondyloArthritis International Society (ASAS40) response at week 16. Safety was evaluated through week 60.ResultsAmong patients initially randomized to IV secukinumab (n = 264) or placebo (n = 262), 86.0% and 88.9% completed the entire 60‐week study period, respectively. A higher proportion of patients receiving secukinumab versus placebo met the primary endpoint (ASAS40 response) at week 16 (40.9% vs 22.9%; P < 0.0001). By week 24, patients who switched from placebo to secukinumab at week 16 achieved ASAS40 response rates comparable to those in patients originally randomized to secukinumab. All secondary efficacy endpoints were met at week 16, and responses were sustained through week 52. No new or unexpected safety signals were observed with IV secukinumab.ConclusionIV secukinumab was effective for the treatment of adults with active axSpA over 52 weeks. The safety profile was consistent with that in previous reports on subcutaneous secukinumab.
Efficacy and Safety of Intravenous Secukinumab for the Treatment of Active Psoriatic Arthritis: Results From a Randomized, Placebo‐Controlled Phase 3 Study
Authors: Kivitz Alan , Sedova Liliana , Churchill Melvin , Kotha Roshan , Singhal Atul , Torres Alexander , Valenzuela Guillermo , Whelan Sarah , Dumortier Thomas , Zhu Xuan , Martin Ruvie , Pricop Luminita 
Published: September 2024

ObjectiveThe aim of this study was to evaluate the efficacy and safety of intravenous (IV) secukinumab in patients with active psoriatic arthritis (PsA).MethodsINVIGORATE‐2 (NCT04209205) was a randomized, placebo‐controlled, phase 3 trial. Patients with active PsA were randomized 1:1 to receive IV secukinumab (6 mg/kg at baseline followed by 3 mg/kg every four weeks [q4w]) or placebo. At week 16, patients randomized to placebo were switched to IV secukinumab (3 mg/kg q4w), and patients who received IV secukinumab continued treatment through week 52. The primary efficacy endpoint was achievement of 50% improvement in American College of Rheumatology response criteria (ACR50) at week 16. Efficacy and safety were evaluated through weeks 52 and 60, respectively.ResultsAmong 191 patients randomized to IV secukinumab and 190 to placebo/IV secukinumab, 177 (92.7%) and 170 (89.5%) completed the entire study period, respectively. A significantly higher proportion of patients who received IV secukinumab versus placebo achieved ACR50 at week 16 (31.4% vs 6.3%; adjusted P < 0.0001). All secondary efficacy endpoints were met at week 16 (all adjusted P < 0.05 using the predefined hypothesis‐testing hierarchy). Patients who switched from placebo to secukinumab at week 16 showed rapid improvements in ACR50 rates; by week 52, both treatment arms experienced similar improvements in efficacy outcomes. No new or unexpected safety signals were observed with receiving IV secukinumab. One death was reported in the placebo group before week 16.ConclusionIV secukinumab led to rapid and sustained improvements in clinical measures of PsA, and the safety profile was consistent with that of secukinumab administered subcutaneously.
Synthesis and characterization of piperine‐modified mesoporous silica nanoparticles for biomedical applications
Authors: Mohan Shimi , Thankaswamy Jarin 
Published: September 2024

AbstractMesoporous silica nanoparticles (MSNs) have displayed high‐potential prospects in biomedical use, especially for drug delivery due to large surface area, tunable pore size and simple surface functionalization. The objective behind the present research is to synthesize and profile piperine‐modified MSNs for their preparation due to antioxidative anticarcinogenic, anti‐inflammatory properties of the alkaloid chosen as a modifier. In the study, silica piperine nanoparticles (SPN) were fabricated based on a modified Stöber method. Characterization techniques including SEM, TEM, AFM, FTIR, XRD, and DSC showed significant differences of incorporated piperine in the production process to plain MSN properties. Piperine was observed to inhibit nanoparticles’ growth so that they became smaller, heterogeneous, with a changed morphology and surface chemistry. As a strong confirmation of covalent incorporation, spectroscopic data showed the presence of electrons in the piperine's functional group that were exchanged into some silanol groups and removed excessive surface energy. The antioxidant activity of SPNs revealed that the silica matrix, and moreover bioactive piperine combination resulted to significant increase in enhanced antioxidant potential. In general, the results of this study offer meaningful lessons about the utilization and manipulation of piperine to suit MSN in a bid to optimize them for biomedical uses such as drug delivery applications where its antioxidant characteristics may bring therapeutic benefits. This holistic characterization and standardization of piperine‐modified MSNs sets the solid stage for further project practice and advance adjustment in aluminosilicate nanostructures designed for biomedical application.
Extracellular glypican‐1 affects tumor progression and prognosis in esophageal cancer
Authors: Shibata Rie , Konishi Hirotaka , Arita Tomohiro , Yamamoto Yusuke , Matsuda Hayato , Yamamoto Taiga , Ohashi Takuma , Shimizu Hiroki , Komatsu Shuhei , Shiozaki Atsushi , Kubota Takeshi , Fujiwara Hitoshi , Otsuji Eigo 
Published: September 2024

AbstractIntroductionCells are covered with a glycan surface layer that is referred to as the glycocalyx (GCX). It has been reported that the formation of the GCX is promoted on cancer cells and is associated with tumor growth and metastasis. Heparan sulfate proteoglycan glypican‐1 (GPC1) is a core protein of the GCX that is overexpressed in esophageal squamous cell carcinoma (ESCC) and is involved in the development and progression of cancer cells. The purpose of the present study is to analyze the utility of GPC1 as a new biomarker ralated to glycocalyx that reflects therapeutic effect and prognosis of ESCC.MethodsWe measured the concentration of GPC1 protein in preoperative plasma from advanced esophageal cancer patients and examined its relationships with clinicopathological factors and therapeutic efficacy, and the effects of extracellular GPC1 were investigated.ResultsThe following clinical factors were significantly correlated with the preoperative high GPC1 concentration: male, tumor size ≥30 mm, venous invasion, pT factor ≥2, pStage ≥3, residual tumor, and distant metastatic recurrence. Both overall and recurrence‐free survival were significantly worse in the high GPC1 group. Extracellular GPC1 protein concentration reflected intracellular GPC1 expression. Furthermore, we examined the effects of extracellular recombinant human (rh)GPC1 on ESCC cells, and found that extracellular rhGPC1 affects cell motility, including migration and invasion.ConclusionsThese results demonstrated the utility of extracellular GPC1 as a biomarker, which can be assayed from a less invasive blood sample‐based liquid biopsy. Extracellular GPC1 protein plays a role in both tumor cell motility and cancer progression. Thus, plasma GPC1 is a useful biomarker for esophageal cancer progression and may be a potential candidate of therapeutic target.