bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bradykinin Promotes Cell Proliferation, Migration, Invasion, and Tumor Growth of Gastric Cancer Through ERK Signaling Pathway
Authors: Wang Guojun , Sun Junfeng , Liu Guanghui , Fu Yang , Zhang Xiefu 
Published: May 2017

ABSTRACTBradykinin (BK) has been reported to be involved in the progression of diverse types of cancer. In the present study, we investigated the possible role of BK in cell proliferation, migration, invasion, and tumor growth of gastric cancer (GC). Cell proliferation was evaluated by MTT assays. Cell migration and invasion were assessed by Transwell assays. Tumor growth of nude mice was detected by establishing subcutaneous xenograft tumor model. Silencing of bradykinin B1 receptor (B1R) and the bradykinin B2 receptor (B2R) was performed by transfecting cells with si‐B1R and si‐B2R, respectively. The protein expression levels of phospho‐ERK1/2 (p‐ERK1/2), matrix metalloproteinase (MMP)‐2, MMP‐9, and E‐Cadherin were examined by Western blot. Data revealed that BK promoted cell proliferation, migration, invasion, and the in vivo tumor growth of GC cells SGC‐7901 and HGC‐27. Furthermore, BK elevated the protein levels of p‐ERK1/2, MMP‐2, and MMP‐9, but reduced E‐Cadherin. In addition, by repressing B2R using si‐B2R or inhibiting ERK signaling pathway using PD98059, BK‐mediated promotion of cell proliferation, migration, and invasion and upregulation of p‐ERK1/2, MMP‐2/9, as well as downregulation of E‐Cadherin were attenuated. Taken together, the present study demonstrated that BK promoted cell proliferation, migration, invasion, and tumor growth by binding to B2R via ERK signaling pathway. Our findings may provide promising options for the further treatment of GC. J. Cell. Biochem. 118: 4444–4453, 2017. © 2017 Wiley Periodicals, Inc.
Relationship of Fibroblast Growth Factor 23 (FGF‐23) Serum Levels With Low Bone Mass in Postmenopausal Women
Authors: Shen Jun , Fu Shiping , Song Yuan 
Published: May 2017

ABSTRACTThe aim of this study was to determine the relationship between serum fibroblast growth factor‐23 (FGF‐23) level and bone mass in postmenopausal women. A total of 60 premenopausal, 60 early postmenopausal, and 60 late postmenopausal women were investigated by the measurement of bone mineral densities (BMDs) at lumbar spine and proximal femur by DXA, together with serum concentrations of Ca, P, 25 (OH) D3, OC, iPTH, CTX‐I, PINP, and FGF‐23. The levels of FGF‐23 and PINP in early postmenopausal group were significantly higher than that in the premenopausal or the late postmenopausal groups, their changing patterns were different form 25(OH)D3, iPTH, IGF, CTX‐I, and OC. According to the AUCs in the ROC analysis, we found that serum FGF‐23 level was associated with the highest validity as compared to the other bone metabolism factors. Further study indicated the significant negative relationships between serum FGF‐23 level and lumbar spine/proximal femur BMDs in postmenopausal women. After detection of the sensitivity and specificity of serum FGF‐ 23 for the low bone mass at different T‐score (SD) lumbar spine/proximal femur BMDs, we found that serum FGF‐23 level may be a reliable marker for low bone mass in postmenopausal women. The performance of FGF‐23 in the differential diagnosis low bone mass from healthy participants indicated that FGF‐23 has the capacity to differentiate the women with low bone mass from the normal ones. Our study indicated that serum FGF‐23 level could be served as the utility in the early detection of women with low bone mass. J. Cell. Biochem. 118: 4454–4459, 2017. © 2017 Wiley Periodicals, Inc.
P120‐Catenin Mediates Intermittent Cyclic Mechanical Tension‐Induced Inflammation in Chondrocytes
Authors: Xu Hong‐guang , Gao Zhi , Ma Ming‐ming , Xu Jia‐jia , Xiao Liang , Wang Hong , Zhang Tao , Liu Xiang , Xu Yong‐ming , Zhang Xiao‐ling 
Published: May 2017

ABSTRACTTo study the role of the nuclear factor (NF)‐κB signaling pathway and P120‐catenin in the inflammatory effects of intermittent cyclic mechanical tension (ICMT) on endplate chondrocytes. Inflammatory reactions of endplate chondrocyte were measured by real‐time reverse transcription‐polymerase chain reaction, enzyme‐linked immunosorbent assays, a dual‐luciferase reporter assay system, immunofluorescence, and Western blot analysis. ICMT loading led to inflammatory reactions of endplate chondrocytes in both the rabbit endplate cartilage model and rat endplate chondrocytes in vitro. Inhibition of NF‐κB signaling significantly ameliorated the inflammation induced by ICMT in endplate chondrocytes. Moreover, the expression of P120‐catenin was decreased by ICMT. However, over‐expression of P120‐catenin suppressed NF‐κB signaling and reversed the inflammatory effects. P120‐catenin prevents endplate chondrocytes from undergoing ICMT‐mediated inflammation by suppressing the expression of NF‐κB. J. Cell. Biochem. 118: 4508–4516, 2017. © 2017 Wiley Periodicals, Inc.
Correlations of ALDH2 rs671 and C12orf30 rs4767364 polymorphisms with increased risk and prognosis of esophageal squamous cell carcinoma in the Kazak and Han populations in Xinjiang province
Authors: Liu Pan , Zhao Hua‐Rong , Li Fang , Zhang Lei , Zhang Hua , Wang Wen‐Ran , Mao Rui , Su Wei‐Peng , Zhang Yang , Bao Yong‐Xing 
Published: May 2017

ObjectiveGenetic polymorphisms in ALDH2 and C12orf30 genes have been reported to increase the risk of developing esophageal squamous cell carcinoma (ESCC). This study aims to investigate the relationship between ALDH2 rs671 and c12orf30 rs4767364 polymorphisms in the chromosome 12q24 gene, and risk and prognosis of individuals developing esophageal cancer (ESCC) in Xinjiang Kazak and Han populations.MethodsThe case group consisted of 127 ESCC patients. The control group comprised of 125 healthy individuals. Subjects that were recruited all come from Xinjiang province. TaqMan and the Hardy‐Weinberg equilibrium were the main methods employed to detect and examine the distribution of genotypes of rs671 and rs4767364.ResultsThe genotype frequencies of ALDH2 rs671 between the Kazak case and control groups were statistically significant, while no significant difference was observed between the Han case and control groups (P>.05). Moreover, ALDH2 rs671 (G>A) was associated with poor prognosis of ESCC in both Kazak and Han populations, and c12orf30 rs4767364 (A>G) was also connected with poor prognosis of ESCC in Kazak but not in Han population.ConclusionIn the chromosome 12q24 locus, ALDH2 rs671 (G>A) is related to the susceptibility to ESCC in Kazak populations, and it is also associated with poor prognosis of EC in Kazak and Han populations. Furthermore, c12orf30 rs4767364 (A>G) may be correlated with poor ESCC prognosis in Kazak population.
A case of tracheo‐innominate artery fistula successfully treated with endovascular stent of the innominate artery
Authors: Yogo Aoi , Komori Masafumi , Yano Yudai , Fujita Koji , Sando Eiichiro , Kotani Mitsuhisa , Sugimura Hiroshi , Ochi Atsushi , Moody Sandra , Yaegashi Makito 
Published: May 2017

AbstractTracheo‐innominate artery fistula (TIF) is a rare but life‐threatening complication of tracheostomy. We describe a 44‐year‐old man who was admitted for a pressure ulcer infection with a third tracheostomy in place. He showed massive hemoptysis from the TIF, followed by cardiopulmonary arrest. The cuff of the tube was hyperinflated; however, even a slight movement of the tube resulted in recurrent massive hemorrhage. Thus, an endovascular stent graft was placed. Our case shows that sentinel bleeding may be found prior to TIF, and an endovascular repair can be a lifesaving temporizing option, when the hemorrhage was not controlled by hyperinflating the cuff of the tube.
Silicosis, then microscopic polyangiitis—antineutrophil cytoplasmic antibodies‐associated vasculitis may be work‐related disease in patients with silicosis
Authors: Nishimura Yoshito , Tsuda Tomohiro , Nishina Shinichi , Omoto Akiyoshi , Misawa Mahito , Yabe Hiroki , Nagao Toshihiko 
Published: May 2017

AbstractA 74‐year‐old man with silicosis was admitted to the hospital because of prolonged fever. After referral to internal medicine for persistent fever and renal dysfunction, workup revealed antineutrophil cytoplasmic antibodies (ANCA) positivity. He was diagnosed with microscopic polyangiitis (MPA). After treatment with immunosuppressive therapy, his condition improved. Herein, we discuss silica exposure and the risk of ANCA‐associated vasculitis (AAV), particularly in terms of work‐related diseases. Silica exposure is a notorious risk factor for developing AAV, which is potentially lethal when not identified. When we see a silicosis patient with new‐onset prolonged fever and generalized fatigue, AAV should be taken into consideration. This case report provides beneficial information to reliably assess patients at high risk of developing AAV in primary care settings.
Noninvasive imaging in cardiac deposition diseases
Authors: Shah Ranjit , Nucifora Gaetano , Perry Rebecca , Selvanayagam Joseph B. 
Published: May 2017

Infiltrative cardiomyopathy represents a heterogeneous group of diseases of the heart tissue with similar phenotypic expression. The condition is rare, but can be easily mistaken for other more common conditions of the heart. The diagnosis of infiltrative cardiomyopathy is therefore challenging and has often required the use of invasive procedures in the past. In the last decade there have been great advances in non‐invasive cardiac imaging modalities like echocardiography, cardiovascular magnetic resonance and nuclear imaging. Although no single imaging modality abnormality on its own is pathognomic for infiltrative cardiomyopathy, a combination of these different modalities are synergistic, and can greatly aid in the clinical diagnosis. In this review, we describe these advancements in non‐invasive cardiac imaging modalities with a particular focus on cardiovascular magnetic resonance imaging.Level of Evidence: 1Technical Efficacy: Stage 3J. Magn. Reson. Imaging 2018;47:44–59.
Perylene‐Containing Conjugated Microporous Polymers for Photocatalytic Hydrogen Evolution
Authors: Xu Yunfeng , Mao Na , Feng Shi , Zhang Chong , Wang Feng , Chen Yu , Zeng Jinghui , Jiang Jia‐Xing 
Published: May 2017

Three perylene‐containing conjugated microporous polymers (PrCMPs) are synthesized via Suzuki–Miyaura cross‐coupling reaction from perylene with four polymerizable functional groups and a range of different substituted benzene derivatives. The pore property and bandgap of the resulting PrCMPs can be tuned by changing the comonomer of benzene with different substituted groups and positions. The photocatalytic performances of the polymers are highly dependent on the surface area, geometry, and bandgap of the PrCMPs. It was found that the 1,2,4,5‐linked polymer of PrCMP‐3 shows the highest hydrogen evolution rate (HER) of 12.1 µmol h−1 under UV–vis light irradiation among the three polymers because of its high surface area, broad light absorption, and suitable bandgap. PrCMP‐3 also exhibits good photocatalytic stability for prolonged hydrogen production reaction. This result demonstrates that the crucial role of the linkage geometry offers a general principle for the rational design of conjugated microporous polymer photocatalysts.
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On Fejér's inequalities for the Legendre polynomials
Authors: Alzer Horst , Kwong Man Kam 
Published: May 2017

AbstractWe present various inequalities for the sum
urn:x-wiley:0025584X:media:mana201600461:mana201600461-math-0001where denotes the Legendre polynomial of degree k. Among others we prove that the inequalities
urn:x-wiley:0025584X:media:mana201600461:mana201600461-math-0003hold for all and . The constant factors 2/5 and are sharp. This refines a classical result of Fejér, who proved in 1908 that is nonnegative for all and .
Bor und Stickstoff statt Kohlenstoff
Authors: Helten Holger , Ayhan Ozan , Lorenz Thomas 
Published: May 2017

AbstractWerden in π‐konjugierten Systemen einige C‐C‐Doppelbindungen durch isoelektronische B‐N‐Einheiten ersetzt, entstehen organisch‐anorganische Hybridmaterialien. Werden nur B‐N‐Einheiten verwendet, ergeben sich Polyiminoborane: neue anorganische Hauptgruppenpolymere, die sich formal von Polyacetylen ableiten.
Erste Hilfe aus dem Meer – vom Schwimmkörper zum Klebstoff
Authors: Grunwald Ingo , von Byern Janek , Zheden Vanessa , Klepal Waltraud 
Published: May 2017

AbstractDie gestielte Meereichel Dosima fascicularis nutzt ein Floß aus einem schaumartigen Proteinhydrogel zum Überleben. Das Gel wäre aufgrund seines Aufbaus und der Zusammensetzung ein idealer Klebstoff für die Medizin.
Electronic π‐to‐π* Excitations of Rhodamine Dyes Exhibit a Time‐Dependent Kohn–Sham Theory “Cyanine Problem”
Authors: Moore Barry , Schrader Robert L. , Kowalski Karol , Autschbach Jochen 
Published: May 2017

AbstractThe longest‐wavelength π‐to‐π* electronic excitations of rhodamine‐like dyes (RDs) with different group 16 heteroatoms (O, S, Se, Te) have been investigated. Time‐dependent Kohn–Sham theory (TDKST) calculations were compared with coupled‐cluster (CC) and equations‐of‐motion (EOM) CC results for π‐to‐π* singlet and triplet excitations. The RDs exhibit characteristics in the TDKST calculations that are very similar to previously investigated cyanine dyes, in the sense that the singlet energies obtained with nonhybrid functionals are too high compared with the CC results at the SD(T) level. The errors became increasingly larger for functionals with increasing amounts of exact exchange. TDKST with all tested functionals led to severe underestimations of the corresponding triplet excitations and overestimations of the singlet–triplet gaps. Long‐range‐corrected range‐separated exchange and “optimal tuning” of the range separation parameter did not significantly improve the TDKST results. A detailed analysis suggests that the problem is differential electron correlation between the ground and excited states, which is not treated sufficiently by the relatively small integrals over the exchange‐correlation response kernel that enter the excitation energy expression. Numerical criteria are suggested that may help identify “cyanine‐like” problems in TDKST calculations of excitation spectra.
Developing local oral reading fluency cut scores for predicting high‐stakes test performance
Authors: Grapin Sally L. , Kranzler John H. , Waldron Nancy , Joyce‐Beaulieu Diana , Algina James 
Published: May 2017

AbstractThis study evaluated the classification accuracy of a second grade oral reading fluency curriculum‐based measure (R‐CBM) in predicting third grade state test performance. It also compared the long‐term classification accuracy of local and publisher‐recommended R‐CBM cut scores. Participants were 266 students who were divided into a calibration sample (n = 170) and two cross‐validation samples (n = 46; n = 50), respectively. Using calibration sample data, local fall, winter, and spring R‐CBM cut scores for predicting students’ state test performance were developed using three methods: discriminant analysis (DA), logistic regression (LR), and receiver operating characteristic curve analysis (ROC). The classification accuracy of local and publisher‐recommended cut scores was evaluated across subsamples. Only DA and ROC produced cut scores that maintained adequate sensitivity (≥.70) across cohorts; however, LR and publisher‐recommended scores had higher levels of specificity and overall correct classification. Implications for developing local cut scores are discussed.
A mixed‐method efficacy and fidelity study of Check and Connect
Authors: Powers Kristin , Hagans Kristi , Linn Megan 
Published: May 2017

AbstractThe effectiveness of the Check and Connect dropout prevention program was examined, over the course of 2 ½ years, with 54 middle school students from diverse backgrounds experiencing one or more conditions of risk for dropout. Participants were randomly assigned to receive the Check and Connect intervention or business as usual (i.e., control) in sixth grade. Students in the treatment group had significantly better eighth grade attendance than the control. There were no significant differences between the two groups in eighth grade cumulative grade point average or office disciplinary referrals. An in‐depth analysis of the quality and quantity of the intervention delivered to the students in the treatment group identified conditions that were associated with higher treatment integrity and better student outcomes.
The Effects of Hydrogenation on Graphitic C3N4 Nanosheets for Enhanced Photocatalytic Activity
Authors: Zhou Minjie , Hou Zhaohui , Chen Xiaobo 
Published: May 2017

AbstractGraphitic carbon nitride (g‐C3N4) has recently been studied as a promising metal‐free catalyst for photocatalytic hydrogen generation and environmental pollution removal. However, its photocatalytic activities are far from satisfactory, partially due to unsatisfied optical absorption and poor charge separation. Hydrogenation has recently been proven as an efficient approach in enhancing the optical absorption and improving the charge separation in oxide photocatalysts. In this study, the effects of hydrogenation on nonoxide g‐C3N4 nanosheets have been elucidated for photocatalytic applications. Hydrogenation introduces structural defects, leads to disaggregation and fragmentation, and increases the specific surface area. And it increases and redshifts the optical absorption, narrows the bandgap, and increases the donor density. The photocatalytic activities are remarkably enhanced for hydrogen production from water by 45% and pollutant removal by 650% under stimulated sunlight irradiation. The enhanced photocatalytic activity is due to the synergistic effects brought by hydrogenation: the increased optical absorption, reduced bandgap, enlarged specific surface area, and increased donor density. Thus, this study shows that hydrogenation can have a wide range of effects on the structural, optical, electronic, and photocatalytic properties of g‐C3N4, providing a facile approach to modify properties and performances of nonoxide photocatalysts.
Die CLC‐Multifunktionsdecke
Authors: Olipitz Michael 
Published: May 2017

AbstractIm vorliegenden Beitrag wird die österreichische Entwicklung einer Multifunktionsdecke beschrieben, die eine ganzheitliche Planung im Sinne nachhaltiger Gebäudekonzepte erfordert. Es genügt keinesfalls, Deckensysteme rein auf die Tragfunktion zu beschränken, sondern diese sollten integrativ und multifunktionell sein. Eine Beschreibung aller Möglichkeiten dieses neuartigen Verbunddeckensystems hinsichtlich Trageigenschaften, Bauphysik und Integration der Gebäudetechnik geben Einblicke für den Anwender. Es handelt sich um eine Stahl‐Verbundbauweise, bei der ein Stahl‐Wellsteg mit Hilfe der Vorspannung einen Formschluss und Verbund ermöglicht und damit eine hohe Ressourceneffizienz aufweist. Das Tragverhalten wurde durch zwei Großversuche bestätigt, die im Folgenden beschrieben werden. Die Systemeigenschaften der CLC‐Multifunktionsdecke im Zusammenwirken mit einem Bodenaufbau geben Einblick in die ganz spezifischen bauphysikalischen Möglichkeiten dieses Systems. Speziell durchgeführte Schallversuche nach EN ISO 10142 Teil 2 und Teil 3 beschreiben die Besonderheiten. Der Brandschutz erfordert getrennte Betrachtungen in allen drei Zonen der Decke. Beispiele für die Anwendung des Deckensystems für Büro‐ und Hotelnutzung zeigen die vielfältigen Anwendungsmöglichkeiten dieses innovativen Deckensystems.
Abbruch und Neubau der ÖBB‐Ennsbrücke Ardning
Authors: Stelzer Barbara , Dorrer Günther 
Published: May 2017

AbstractDer Abbruch und Neubau der ÖBB‐Ennsbrücke in Ardning auf der Strecke Linz–Selzthal km 101,121 erfolgt im Zuge der Totalsperre für die Sanierung des Bosrucktunnels und ermöglicht es, die im Jahre 1905 errichtete Bestandsbrücke rückzubauen. Das neue Tragwerk ist auf zukünftig zu erwartende Einwirkungen ausgelegt und erhöht durch das nun durchgehend vorhandene Schotterbett den Fahrkomfort für die Reisenden. Die vorgesehene Errichtung in Brückenendlage in Kombination mit den engen zeitlichen Rahmenbedingungen stellt alle Beteiligten vor große Herausforderungen und regt zum Nachdenken über alternative Montagekonzepte an.
An amazing ring – Die neue ÖAMTC‐Zentrale
Authors: Mühl Bernd , Ebner Dieter 
Published: May 2017

AbstractAm Standort Baumgasse 129 im dritten Wiener Gemeindebezirk, unmittelbar an der am stärksten befahrenen Straße Österreichs, wurde im März 2017 die neue Zentrale des Österreichischen Automobil‐, Motorrad‐ und Touringclub ÖAMTC eröffnet. Auf neun Ebenen des so genannten Mobilitätszentrums, mit einer Bruttogeschossfläche von 27 000 m2, entstanden Büro‐, Konferenz‐ und Schulungsräumlichkeiten. Diese bieten ein innovatives Arbeitsumfeld für rund 800 Mitarbeiter und fassen gleichzeitig fünf Bürostandorte zentral zusammen. Das Gebäude ist in Form einer Felge mit fünf „Bürospeichen” angelegt. Die 230 m lange und beinahe 17 m hohe Ringfassade ist das architektonische Highlight der neuen ÖAMTC‐Zentrale und bildet gleichzeitig das verbindende Element, das sich von Speiche zu Speiche erstreckt und somit einerseits als Schutzwand zur Wiener Südosttangente dient, andererseits konnten so die Fluchtwege aus den Büroräumlichkeiten konstruktiv in die Stahlkonstruktion integriert werden. Somit konnten die Tiefen des Bürogebäudes ausgenutzt und die Massivtreppenhäuser kleiner gehalten werden. Die prominent positionierte Stahl‐Glaskonstruktion der Ringfassade konnte durch den konsequenten Einsatz von BIM‐(Building Information Modeling)Technologien im Zuge der Ausführungsplanung durch das Zusammenspiel der planenden Architekten, des Tragwerksplaners und der ausführenden Unternehmen umgesetzt werden. Für die Ringfassade, die Hochgarage, den Hangar, den Heliport sowie die sieben Atriumstiegen zeichnet die international tätige Unger Steel Group aus Oberwart/Österreich verantwortlich.
Neuartige Sandwichfahrbahnplatte für Eisenbahnbrücken
Authors: Takács Patrik , Fink Josef 
Published: May 2017

AbstractAn der Technischen Universität Wien wird am Institut für Tragkonstruktionen im Forschungsbereich für Stahlbau eine neue, extrem schlanke Steel‐Concrete‐Steel‐Composite (SCSC)‐Platte untersucht, mit der wesentliche Randbedingungen (niedrige Bauhöhe, Reduktion Lärmemission durch Schotteroberbau) bei Ersatzneubauten von Eisenbahnbrücken älterer Bauart befriedigt werden. Der mehrschichtige Aufbau der Platte besteht aus zwei außenliegenden Stahlblechen mit unbewehrtem Betonkern, daher der Name Sandwichplatte. Lochdübelleisten, wechselweise nur am oberen und nur am unteren Blech angeschweißt, dienen der Schubübertragung zwischen den äußeren Blechen durch die Aktivierung von diagonal liegenden, horizontalen Betondruckstreben zwischen benachbarten Dübelleisten. Zusätzlich zur Weiterleitung der Vertikallasten in Querrichtung zu den Hauptträgern wirkt die SCSC‐Platte als Untergurt der Brückenhauptträger. Untersuchungen zur Tragfähigkeit ohne Ermüdung sowie die Erläuterung des Tragmechanismus der SCSC‐Platte erfolgten in ([1], [2] und [3]). Die rechnerische Beurteilung des Tragverhaltens bei Ermüdungsbeanspruchungen wird in dieser Arbeit vorgestellt, wobei der Fokus auf das Ermüdungsverhalten der Lochdübelleiste der SCSC‐Platte gerichtet ist.Die Ermüdungsanalysen wurden anhand eines nichtlinearen, dreidimensionalen Finite‐Elemente‐Modells als Grundlage für die Lebensdauerberechnung mithilfe der Kerbdehnungsmethode durchgeführt [4]. Ziel ist es, die Beziehung zwischen dem Niveau der Verkehrslast (Lastmodell LM71) und der ertragbaren Anzahl der Schwingspiele bis Rissbildung in den Dübelleisten entsteht, zu bestimmen. Dieser Beitrag gibt einen Überblick über die Ansätze und Ergebnisse zur Berechnung der Lebensdauer der Lochdübelleiste als Konstruktionselement mit Schlüsselfunktion (Schubübertragung durch Betondruckstreben) für die Tragwirkung der SCSC‐Platte und eine kurze Zusammenfassung der signifikanten Ergebnisse.