bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial
Authors: Ruschitzka Frank , Borer Jeffrey S , Krum Henry , Flammer Andreas J , Yeomans Neville D , Libby Peter , Lüscher Thomas F , Solomon Daniel H , Husni M Elaine , Graham David Y , Davey Deborah A , Wisniewski Lisa M , Menon Venu , Fayyad Rana , Beckerman Bruce , Iorga Dinu , Lincoff A Michael , Nissen Steven E 
Published: August 2017

Aims
Non-steroidal anti-inflammatory drugs (NSAIDs), both non-selective and selective cyclooxygenase-2 (COX-2) inhibitors, are among the most widely prescribed drugs worldwide, but associate with increased blood pressure (BP) and adverse cardiovascular (CV) events. PRECISION-ABPM, a substudy of PRECISION was conducted at 60 sites, to determine BP effects of the selective COX-2 inhibitor celecoxib vs. the non-selective NSAIDs naproxen and ibuprofen.

Methods and results
In this double-blind, randomized, multicentre non-inferiority CV-safety trial, 444 patients (mean age 62 ± 10 years, 54% female) with osteoarthritis (92%) or rheumatoid arthritis (8%) and evidence of or at increased risk for coronary artery disease received celecoxib (100–200 mg bid), ibuprofen (600–800 mg tid), or naproxen (375–500 mg bid) with matching placebos in a 1: 1: 1 allocation, to assess the effect on 24-h ambulatory BP after 4 months. The change in mean 24-h systolic BP (SBP) in celecoxib, ibuprofen and naproxen-treated patients was -0.3 mmHg [95% confidence interval (CI), −2.25, 1.74], 3.7 (95% CI, 1.72, 5.58) and 1.6 mmHg (95% CI, −0.40, 3.57), respectively. These changes resulted in a difference of − 3.9 mmHg (P = 0.0009) between celecoxib and ibuprofen, of − 1.8 mmHg (P = 0.12) between celecoxib and naproxen, and of − 2.1 mmHg (P = 0.08) between naproxen and ibuprofen. The percentage of patients with normal baseline BP who developed hypertension (mean 24-h SBP ≥ 130 and/or diastolic BP ≥ 80 mmHg) was 23.2% for ibuprofen, 19.0% for naproxen, and 10.3% for celecoxib (odds ratio 0.39, P = 0.004 and odds ratio 0.49, P = 0.03 vs. ibuprofen and naproxen, respectively).

Conclusions
In PRECISION-ABPM, allocation to the non-selective NSAID ibuprofen, compared with the COX-2 selective inhibitor celecoxib was associated with a significant increase of SBP, and a higher incidence of new-onset hypertension.

ClinicalTrials
gov number NCT00346216
Feeling Economically Stuck: The Effect of Perceived Economic Mobility and Socioeconomic Status on Variety Seeking
Authors: Yoon Sunyee , Kim Hyeongmin Christian 
Published: August 2017

AbstractFive studies provide converging evidence for the joint effect of perceived economic mobility and socioeconomic status (SES) on compensatory behavior, such that low SES consumers who perceive low economic mobility (i.e., economically stuck consumers) seek more variety than other consumers. We trace this effect to these consumers’ desire to compensate for their low sense of personal control. Furthermore, we show that these consumers’ variety-seeking tendency disappears when their sense of control is boosted by other means or when the more varied option is not associated with a sense of control. Alternative explanations based on instrumental benefits, reactance, and affect were tested and did not account for the effect. Thus, the current research provides fresh insights to consumer research by contributing to the literature on compensatory behavior, variety seeking, and SES.
Lateral Cerebellar Nucleus Stimulation has Selective Effects on Glutamatergic and GABAergic Perilesional Neurogenesis After Cortical Ischemia in the Rodent Model
Authors: Chan Hugh H , Cooperrider Jessica , Chen Zhihong , Gale John T , Baker Kenneth B , Wathen Connor A , Modic Claire R , Park Hyun-Joo , Machado Andre G 
Published: August 2017

Abstract

BACKGROUND
Chronic deep brain stimulation of the rodent lateral cerebellar nucleus (LCN) has been demonstrated to enhance motor recovery following cortical ischemia. This effect is concurrent with synaptogenesis and expression of long-term potentiation markers in the perilesional cerebral cortex.

OBJECTIVE
To further investigate the cellular changes associated with chronic LCN stimulation in the ischemic rodent by examining neurogenesis along the cerebellothalamocortical pathway.

METHODS
Rats were trained on the pasta matrix task, followed by induction of cortical ischemia and electrode implantation in the contralesional LCN. Electrical stimulation was initiated 6 wk after stroke induction and continued for 4 wk prior to sacrifice. Neurogenesis was examined using immunohistochemistry.

RESULTS
Treated animals showed enhanced performance on the pasta matrix task relative to sham controls. Increased cell proliferation colabeled with 5’-Bromo-2’-deoxyuridine and neurogenic markers (doublecortin) was observed in the perilesional cortex as well as bilateral mediodorsal and ventrolateral thalamic subnuclei in treated vs untreated animals. The neurogenic effect at the level of motor cortex was selective, with stimulation-treated animals showing greater glutamatergic neurogenesis but significantly less GABAergic neurogenesis.

CONCLUSION
These findings suggest that LCN deep brain stimulation modulates postinjury neurogenesis, providing a possible mechanistic foundation for the associated enhancement in poststroke motor recovery.
Burden-driven feedback control of gene expression
Authors: Ceroni F , Furini S , Gorochowski TE , Boo A , Borkowski O , Ladak YN , Awan AR , Gilbert C , Stan GB , Ellis T 
Published: August 2017

ABSTRACTCells use feedback regulation to ensure robust growth despite fluctuating demands on resources and different environmental conditions. Yet the expression of foreign proteins from engineered constructs is an unnatural burden on resources that cells are not adapted for. Here we combined multiplex RNAseq with anin vivoassay to reveal the major transcriptional changes in twoE. colistrains when a set of inducible synthetic constructs are expressed. We identified that native promoters related to the heat-shock response activate expression rapidly in response to synthetic expression, regardless of the construct. Using these promoters, we built a CRISPR/dCas9-based feedback regulation system that automatically adjusts synthetic construct expression in response to burden. Cells equipped with this general-use controller maintain capacity for native gene expression to ensure robust growth and as such outperform unregulated cells at protein yields in batch production. This engineered feedback is the first example of a universal, burden-based biomolecular control system and is modular, tuneable and portable.
ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins
Authors: Krassowski Michal , Paczkowska Marta , Cullion Kim , Huang Tina , Dzneladze Irakli , Francis Ouellette B. F. , Yamada Joseph T. , Fradet-Turcotte Amelie , Reimand Jüri 
Published: August 2017

AbstractInterpretation of genetic variation is required for understanding genotype-phenotype associations, mechanisms of inherited disease, and drivers of cancer. Millions of single nucleotide variants (SNVs) in human genomes are known and thousands are associated with disease. An estimated 20% of disease-associated missense SNVs are located in protein sites of post-translational modifications (PTMs), chemical modifications of amino acids that extend protein function. ActiveDriverDB is a comprehensive human proteo-genomics database that annotates disease mutations and population variants using PTMs. We integrated >385,000 published PTM sites with ∼3.8 million missense SNVs from The Cancer Genome Atlas (TCGA), the ClinVar database of disease genes, and inter-individual variation from human genome sequencing projects. The database includes interaction networks of proteins, upstream enzymes such as kinases, and drugs targeting these enzymes. We also predicted network-rewiring impact of mutations by analyzing gains and losses of kinase-bound sequence motifs. ActiveDriverDB provides detailed visualization, filtering, browsing and searching options for studying PTM-associated SNVs. Users can upload mutation datasets interactively and use our application programming interface for pipelines. Integrative analysis of SNVs and PTMs helps decipher molecular mechanisms of phenotypes and disease, as exemplified by case studies of disease genesTP53,BRCA2andVHL. The open-source database is available athttps://www.ActiveDriverDB.org.
Widespread utilization of passive energy recapture in swimming medusae
Authors: Gemmell Brad J. , Colin Sean P. , Costello John H. 
Published: August 2017

AbstractRecently, it has been shown that some medusae are capable of swimming very efficiently, i.e.; with a low cost of transport, and that this is in part due to passive energy recapture (PER) which occurs during bell relaxation. We compared the swimming kinematics among a diverse array of medusae, varying in taxonomy, morphology and propulsive and foraging modes, in order to evaluate the prevalence of PER in medusae. We found that while PER is commonly observed among taxa, the magnitude of the contribution to overall swimming varied greatly. The ability of medusae to utilize PER was not related to morphology and swimming performance but was controlled by their swimming kinematics. Utilizing PER required the medusae to pause after bell expansion and individuals could modulate their PER by changing their pause duration. Passive energy recapture can greatly enhance swimming efficiency but there appear to be trade-offs associated with utilizing PER.
Intrinsic functional connectivity of the central extended amygdala
Authors: Tillman Rachael M. , Stockbridge Melissa D. , Nacewicz Brendon M. , Torrisi Salvatore , Fox Andrew S. , Smith Jason F. , Shackman Alexander J. 
Published: August 2017

ABSTRACTThe central extended amygdala (EAc)—including the bed nucleus of the stria terminalis (BST) and central nucleus of the amygdala (Ce)—plays a key role in orchestrating states of fear and anxiety and is implicated in the development and maintenance of anxiety disorders, depression, and substance abuse. Although it is widely thought that these disorders reflect the coordinated actions of large-scale functional circuits in the brain, the architecture of the EAc functional network, and the degree to which the BST and the Ce show distinct patterns of intrinsic functional connectivity, remains incompletely understood. Here, we leveraged a combination of approaches to trace the connectivity of the BST and the Ce in 130 psychiatrically healthy, racially diverse, community-dwelling adults with enhanced power and precision. Multiband imaging, high-precision data registration techniques, and spatially unsmoothed data were used to maximize anatomical specificity. Using newly developed seed regions, whole-brain regression analyses revealed robust functional connectivity between the BST and Ce via the sublenticular extended amygdala (‘substantia innominata’), the ribbon of subcortical gray matter encompassing the ventral amygdalofugal pathway. Both regions displayed significant coupling with the ventromedial prefrontal cortex (vmPFC), midcingulate cortex (MCC), insula, and anterior hippocampus. The BST showed significantly stronger connectivity with prefrontal territories—including the vmPFC, anterior MCC and pregenual anterior cingulate cortex—as well as the thalamus, striatum, and the periaqueductal gray. The only regions showing stronger functional connectivity with the Ce were located in the anterior hippocampus and dorsal amygdala. These observations provide a baseline against which to compare a range of special populations, inform our understanding of the role of the EAc in normal and pathological fear and anxiety, and highlight the value of several new approaches to image registration which may be particularly useful for researchers working with ‘de-identified’ neuroimaging data.GRAPHICAL ABSTRACTIntrinsic functional connectivity of bed nucleus of the stria terminalis (BST) and the central nucleus of the amygdala (Ce) in 130 psychiatrically healthy adults.HIGHLIGHTSBST and Ce implicated in normal and pathological fear and anxietyTraced the intrinsic functional connectivity of the BST and the Ce in 130 adultsMultiband imaging, high-precision registration, unsmoothed data, newly developed seedsBST and Ce show robust coupling with one another, hippocampus, insula, MCC, and vmPFCBST shows stronger coupling with prefrontal/cingulate territories and brainstem/PAG
Accurate typing of class I human leukocyte antigen by Oxford nanopore sequencing
Authors: Liu Chang , Xiao Fangzhou , Hoisington-Lopez Jessica , Lang Kathrin , Quenzel Philipp , Duffy Brian , Mitra Robi David 
Published: August 2017

ABSTRACTOxford Nanopore Technologies’ MinION has expanded the current DNA sequencing toolkit by delivering long read lengths and extreme portability. The MinION has the potential to enable expedited point-of-care human leukocyte antigen (HLA) typing, an assay routinely used to assess the immunological compatibility between organ donors and recipients, but the platform’s high error rate makes it challenging to type alleles with clinical-grade accuracy. Here, we developed and validated Athlon, an algorithm that iteratively scores nanopore reads mapped to a hierarchical database of HLA alleles to arrive at a consensus diploid genotype; Athlon achieved a 100% accuracy in class I HLA typing at high resolution.
Facilitated analysis of large data sets by interactive visualisation
Authors: Lu Zhigang , Zhang Yanyan 
Published: August 2017

AbstractIn biological research analysis of large data sets, such as RNA-seq gene expression, often involves visualisation of thousands of data points and associated database query. Static charts produced by traditional tools lack the ability to reveal underlying information, and separated database query is laborious and involves a lot of manual effort. Interactive charting is able to make the data transparent but the use of visualisation tools often requires certain programming skills, which hinders most academic users. We present here an open-source chart editor for interactive visualisation, which is designed for academic users with no programming experience. It can not only visualise the data in an interactive way, but also link the data points to external databases, by which the user can save a lot of manual effort. We believe that interactive visualisation using such tools will facilitate analysis of large data sets as well as presenting and interpreting the data.
DrugPattern: a web-based tool for drug set enrichment analysis
Authors: Huang Chuanbo , Yang Weili , Wang Junpei , Zhou Yuan , Geng Bin , Kararigas Georgios , Yang Jichun , Cui Qinghua 
Published: August 2017

ABSTRACTSet enrichment analysis based methods (e.g. gene set enrichment analysis) have provided great helps in mining patterns in biomedical datasets, however, tools for inferring regular patterns in drug-related datasets are still limited. For the above purpose, here we developed a web-based tool, DrugPattern. DrugPattern first collected and curated 7019 drug sets, including indications, adverse reaction, targets, pathways etc. For a list of interested drugs, DrugPattern then evaluates the significance of the enrichment of these drugs in each of the 7019 drug sets. To validate DrugPattern, we applied it to predict the potential protective roles of oxidized low-density lipoprotein (oxLDL), a widely accepted deleterious factor for the body. We predicted that oxLDL has beneficial effects on some diseases, most of which were supported by literature except type 2 diabetes (T2D), in which oxLDL was previously believed to be a risk factor. Animal experiments further validated that oxLDL indeed has beneficial effects on T2D. These data confirmed the prediction accuracy of our approach and revealed unexpected protective roles for oxLDL in various diseases including T2D. This study provides a tool to infer regular patterns in biomedical datasets based on drug set enrichment analysis.
Disease mediated changes to life history and demography threaten the survival of European amphibian populations
Authors: Campbell Lewis J. , Garner Trenton W. J. , Tessa Giulia , Scheele Benjamin C. , Griffiths Amber G.F. , Wilfert Lena , Harrison Xavier A. 
Published: August 2017

AbstractInfectious diseases can influence the life history strategy of their hosts and such influences subsequently impact the demography of infected populations, reducing viability independently of increased mortality or morbidity. Amphibians are the most threatened group of vertebrates and emerging infectious diseases play a large role in their population declines. Viruses of genusRanavirusare responsible for one of the deadliest of these diseases. To date no work has evaluated the impact of ranaviruses on host life-history post metamorphosis or population demographic structure at the individual level. In this study, we used skeletochronology and morphology to evaluate the impact of ranaviruses on the demography of populations of European common frog (Rana temporaria) in the United Kingdom. We compared ecologically similar populations that differed only in their historical presence or absence of ranaviral disease. Our results suggest that ranaviruses are associated with shifts in the age structure of infected populations, potentially caused by increased adult mortality and associated shifts in the life history of younger age classes. Population projection models indicate that such age truncation could heighten the vulnerability of frog populations to stochastic environmental challenges. Our individual level data provide further compelling evidence that the emergence of infectious diseases can alter host demography, subsequently increasing population vulnerability to additional stressors.
Acute Hepatitis E Virus infection in two geographical regions of Nigeria
Authors: Ifeorah I.M. , Faleye T. O. C. , Bakarey A. S. , Adewumi M. O. , Akere A. , Omoruyi E. C. , Ogunwale A. O. , Adeniji J. A. 
Published: August 2017

AbstractHepatitis E virus (HEV) remains a major public health concern in resource limited regions of the world. Yet data reporting is suboptimal and surveillance system inadequate. In Nigeria, there is dearth of information on prevalence of acute HEV infection. This study was therefore designed to describe acute HEV infection among antenatal clinic attendees and asymptomatic community dwellers from two geographical regions in Nigeria.In this study 750 plasma samples were tested for HEV IgM by Enzyme Linked lmmunosorbent Assay (ELISA) technique. The tested samples were randomly selected from a pool of 1,115 samples previously collected from selected populations (pregnant women – 272, Oyo community dwellers – 438, Anambra community dwellers – 405) for viral hepatitis studies between September 2012 and August 2013.One (0.4%) pregnant woman in her 3rdtrimester had detectable HEV IgM, while community dwellers from the two study locations had zero prevalence rates of HEV IgM.Detection of HEV IgM in a pregnant woman, especially in her 3rdtrimester is of clinical and epidemiological significance. The need therefore exists for establishment of a robust HEV surveillance system in Nigeria, and especially amidst the pregnant population in a bid to improve maternal and child health.
Explaining the expense ratio of international equity funds
Authors: Low Soo-Wah 
Published: August 2017

Purpose
The purpose of this paper is to examine the determinants of fund expense ratio for Malaysia-based international equity funds. An understanding of what these factors are and how they affect a fund’s expense ratio is important given that international funds can be expensive to operate and that fund expenses have negative impact on investors’ returns.

Design/methodology/approach
This study employs a standard cross-sectional regression model in examining the factors that influence fund expense ratio of international equity funds.

Findings
The findings show that sales charge is positively related to fund expense ratio although it is not included in the expense ratio computation. This suggests that investor could possibly incur additional “hidden cost” since sales charge represents an upfront cost that an investor has already paid at the time of the fund sale. Additionally, funds with aggressive investment objective and frequent portfolio turnover show higher expense ratios than funds with conservative investment objective and less trading activities. There is no evidence that fund size, fund age, and the number of funds in a fund family are significantly related to the fund expense ratio. While the lack of statistical finding for fund size in this study seems inconsistent with the results of the US market in general, the finding is supportive of the Thai equity fund market and thus implying that finding could be country specific.

Research limitations/implications
There is limited availability of international equity funds in Malaysia.

Practical implications
The findings provide useful insights for investors to make informed international fund selection decisions. Expense-conscious investors should pay particular attention to fund’s sales charge, turnover ratio, and its investment objective when selecting funds for investment.

Originality/value
This paper provides first evidence on the determinants of fund expense ratio of Malaysia-based international equity funds.
The influence of price and promotion on package size propensity
Authors: Ghosh Amit K. 
Published: August 2017

Purpose
The constantly changing prices, promotions, and packaging options have made decision making more complex for consumers of packaged goods. The purpose of this paper is to explore how price and promotions influence consumer propensity to buy a certain package size.

Design/methodology/approach
Scanner panel data for shelf-stable salad dressing obtained from Information Resources Inc. were used to compute the proportion of large packages bought, the relative price paid for large packages, propensity to use various types of promotions, and a behavioral covariate for each household. Data of over 5,600 households were analyzed using a multiple regression analysis for hypothesis testing.

Findings
The positive nature of relationship between the relative price of large packages and the proportion of large packages bought demonstrates the suboptimal nature of consumer decision making. The inefficiency is partially attributable to the abundance of promotions, to consumers’ lack of price awareness, and to the use of heuristics by consumers. Also, consumers who are prone to use promotions such as displays and temporary price reductions tend to purchase larger packages. They are more likely to buy impulsively and base their decisions on heuristics. In contrast, consumers who are influenced by featured price cuts and who utilize coupons tend to purchase smaller packages.

Research limitations/implications
Data were obtained from grocery stores; only a single product category was studied.

Practical implications
Offer coupons and advertise featured price cuts on small packages to increase the sales of smaller packages. To move large packages successfully, retailers should rely more on in-store displays and temporary price reductions.

Originality/value
The impact of price and promotions on package size propensity has never been investigated. This study is also one of the few that uses a household-level analysis based on observable purchase data for consumer packaged goods.