bluuebunny/crossref_metadata_2025_split huggingface dataset:
To be or not to be (an older driver): social identity theory and driving cessation in later life
Authors: PACHANA NANCY A. , JETTEN JOLANDA , GUSTAFSSON LOUISE , LIDDLE JACKI 
Published: June 2016

ABSTRACTAnticipated driving cessation required due to health or cognitive decline often evokes concerns about practical aspects of retaining mobility and quality of life as well as personal and social identity changes in older persons. While driving cessation is often perceived as stressful because it disrupts peoples' lives and poses practical hurdles, we argue that part of the stress associated with driving cessation can be attributed to identity change with regard to thinking of oneself as ‘no longer a driver’ as well as the perception of ‘getting old’. In an exploratory study, 208 older adults who had either ceased driving or had a plan to stop driving in the near future completed a ‘Driver Identity Survey’ with multiple questions about how they thought they would feel before and after stopping driving, as well as worries about practical hassles, life changes and changed relationships. Participants reported driving cessation as a significant life event associated with subjectively feeling older. Irrespective of current driving status, older participants identified the state of having ceased driving as associated with feeling older than their chronological age. Participants' expectations about practicalities and social identity changes were both significant predictors of stress associated with driving cessation. Discussion focuses on how expectations of anticipated changes in functionality and identity may influence driving cessation decisions and adjustment in later life.
Children's on-line processing of epistemic modals
Authors: MOSCATI VINCENZO , ZHAN LIKAN , ZHOU PENG 
Published: June 2016

AbstractIn this paper we investigated the real-time processing of epistemic modals in five-year-olds. In a simple reasoning scenario, we monitored children's eye-movements while processing a sentence with modal expressions of different force (might/must). Children were also asked to judge the truth-value of the target sentences at the end of the reasoning task. Consistent with previous findings (Noveck, 2001), we found that children's behavioural responses were much less accurate compared to adults. Their eye-movements, however, revealed that children did not treat the two modal expressions alike. As soon as a modal expression was presented, children and adults showed a similar fixation pattern that varied as a function of the modal expression they heard. It is only at the very end of the sentence that children's fixations diverged from the adult ones. We discuss these findings in relation to the proposal that children narrow down the set of possible outcomes in undetermined reasoning scenarios and endorse only one possibility among several (Acredolo & Horobin, 1987, Ozturk & Papafragou, 2015).
I.—The Influence of James Geikie's Researches on the Development of Glacial Geology
Authors: Horne John 
Published: June 2016

My first duty is to express my cordial thanks to the Council and Fellows of this Society for electing me as President in succession to the late Professor Geikie. I have accepted the honour with great reluctance, for I am conscious of the fact that others have far stronger claims, and have waived their claims under very exceptional circumstances. But I may take this opportunity of assuring the Fellows that since they have been pleased to confirm the recommendation of the Council, I shall take an active interest in the affairs of the Society and do my best to promote its welfare.The list of papers read during the past session shows that important contributions relating to different branches of science have been made to the Society. Notwithstanding the strain caused by the war, the output of original work is noteworthy. In this connection reference may be made to some researches having a direct bearing on the war. Last session the Council appointed a Committee, composed of leading scientists, to conduct investigations in connection with submarines, aeroplanes, asphyxiating gas, and high explosives.
New Light on the Sedition Act of 1798: The Missing Half of the Prosecutions
Authors: Bird Wendell 
Published: June 2016

Federalist enforcement machinery ground out at least seventeen verifiable indictments. Fourteen were found under the Sedition Act, and three were returned under the common law … .James Morton Smith
A spate of recent books, and even a smash Broadway musical (Hamilton), have celebrated the Federalist Party for state-building, active government, decisive leadership, forward-looking plans, and other political virtues. However, the rehabilitation of the Federalists cannot succeed without successfully confronting the Alien and Sedition Acts, which the Hamiltonian Federalists sponsored and which the recent books tend to speak softly about (and to which the musical does not give a song).
Violations of the International Code of Marketing of Breast-milk Substitutes: Indonesia context
Authors: Hidayana Irma , Februhartanty Judhiastuty , Parady Vida A 
Published: June 2016

AbstractObjectivesTo measure compliance with the International Code of Marketing of Breast-milk Substitutes (‘the Code’) in Indonesia.DesignThe study was a cross-sectional survey using the Interagency Group on Breastfeeding Monitoring protocol.SettingPublic and private health facilities in six provinces on Java island in Indonesia.SubjectsA total of 874 women (382 pregnant women and 492 breast-feeding mothers of infants below 6 months) and seventy-seven health workers were recruited from eighteen participating health facilities. The study also analysed a total of forty-four labels of breast-milk substitute products, twenty-seven television commercials for growing-up milk (for children >12 months) of nine brands and thirty-four print advertisements of fourteen brands.ResultsThe study found that 20 % of the women had received advice and information on the use of breast-milk substitutes and 72 % had seen promotional materials for breast-milk substitutes. About 15 % reported receiving free samples and 16 % received gifts. Nearly a quarter of the health workers confirmed receiving visits from representatives of breast-milk substitute companies. Two health workers reported having received gifts from the companies. The most common labelling violations found were statements or visuals that discouraged breast-feeding and the absence of mention about the consideration of local climate in the expiration date.ConclusionsViolations of the Code by health workers, breast-milk substitute companies and their representatives were found in all provinces studied. A regular monitoring system should be in place to ensure improved compliance with and enforcement of the Code.
Interstitial rules and the contested application of human rights law and the laws of war in counterterrorism
Authors: NEWELL MICHAEL E. 
Published: June 2016

Abstract:The laws of war and international human rights law (IHRL) overlap, often with competing obligations. When two or more areas of the law overlap, political agents attempt to address these areas of ambiguity with interstitial rules. However, a lack of consensus on interstitial rules can destabilise the law, leading to increased contestation of legal norms and principles. Such is the case for international law in counterterrorism. Prior to the 11 September 2001 attacks (9/11), international agreements and US domestic practices placed counterterrorism within the framework of law enforcement. After 9/11, the Bush Administration replaced law enforcement with armed conflict and the laws of war as the dominant paradigm for counterterrorism, but this decision, among other legal justifications in the War on Terror, has been contested by the international legal community. As IHRL still applies in law enforcement operations, international law in counterterrorism now sits within a contested overlap of IHRL and the laws of war. The contestation of US policies in the War on Terror, including the use of drone strikes in particular, is a product of this unresolved overlap and the lack of clear interstitial rules. Lacking these rules, US counterterrorism policies risk undermining the rule of law.
Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease
Authors: Celardo I , Costa A C , Lehmann S , Jones C , Wood N , Mencacci N E , Mallucci G R , Loh S H Y , Martins L M 
Published: June 2016

AbstractMutations in PINK1 and PARKIN cause early-onset Parkinson’s disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1 and parkin mutants, defective mitochondria also give rise to endoplasmic reticulum (ER) stress signalling, specifically to the activation of the protein kinase R-like endoplasmic reticulum kinase (PERK) branch of the unfolded protein response (UPR). We show that enhanced ER stress signalling in pink1 and parkin mutants is mediated by mitofusin bridges, which occur between defective mitochondria and the ER. Reducing mitofusin contacts with the ER is neuroprotective, through suppression of PERK signalling, while mitochondrial dysfunction remains unchanged. Further, both genetic inhibition of dPerk-dependent ER stress signalling and pharmacological inhibition using the PERK inhibitor GSK2606414 were neuroprotective in both pink1 and parkin mutants. We conclude that activation of ER stress by defective mitochondria is neurotoxic in pink1 and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria. A video abstract for this article is available online in the supplementary information
Operating organic light-emitting diodes imaged by super-resolution spectroscopy
Authors: King John T. , Granick Steve 
Published: June 2016

AbstractSuper-resolution stimulated emission depletion (STED) microscopy is adapted here for materials characterization that would not otherwise be possible. With the example of organic light-emitting diodes (OLEDs), spectral imaging with pixel-by-pixel wavelength discrimination allows us to resolve local-chain environment encoded in the spectral response of the semiconducting polymer, and correlate chain packing with local electroluminescence by using externally applied current as the excitation source. We observe nanoscopic defects that would be unresolvable by traditional microscopy. They are revealed in electroluminescence maps in operating OLEDs with 50 nm spatial resolution. We find that brightest emission comes from regions with more densely packed chains. Conventional microscopy of an operating OLED would lack the resolution needed to discriminate these features, while traditional methods to resolve nanoscale features generally cannot be performed when the device is operating. This points the way towards real-time analysis of materials design principles in devices as they actually operate.
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance
Authors: Gautheron Jérémie , Vucur Mihael , Schneider Anne T. , Severi Ilenia , Roderburg Christoph , Roy Sanchari , Bartneck Matthias , Schrammen Peter , Diaz Mauricio Berriel , Ehling Josef , Gremse Felix , Heymann Felix , Koppe Christiane , Lammers Twan , Kiessling Fabian , Van Best Niels , Pabst Oliver , Courtois Gilles , Linkermann Andreas , Krautwald Stefan , Neumann Ulf P. , Tacke Frank , Trautwein Christian , Green Douglas R. , Longerich Thomas , Frey Norbert , Luedde Mark , Bluher Matthias , Herzig Stephan , Heikenwalder Mathias , Luedde Tom 
Published: June 2016

AbstractReceptor-interacting protein kinase 3 (RIPK3) mediates necroptosis, a form of programmed cell death that promotes inflammation in various pathological conditions, suggesting that it might be a privileged pharmacological target. However, its function in glucose homeostasis and obesity has been unknown. Here we show that RIPK3 is over expressed in the white adipose tissue (WAT) of obese mice fed with a choline-deficient high-fat diet. Genetic inactivation of Ripk3 promotes increased Caspase-8-dependent adipocyte apoptosis and WAT inflammation, associated with impaired insulin signalling in WAT as the basis for glucose intolerance. Similarly to mice, in visceral WAT of obese humans, RIPK3 is overexpressed and correlates with the body mass index and metabolic serum markers. Together, these findings provide evidence that RIPK3 in WAT maintains tissue homeostasis and suppresses inflammation and adipocyte apoptosis, suggesting that systemic targeting of necroptosis might be associated with the risk of promoting insulin resistance in obese patients.
Loss-tolerant state engineering for quantum-enhanced metrology via the reverse Hong–Ou–Mandel effect
Authors: Ulanov Alexander E. , Fedorov Ilya A. , Sychev Demid , Grangier Philippe , Lvovsky A. I. 
Published: June 2016

AbstractHighly entangled quantum states, shared by remote parties, are vital for quantum communications and metrology. Particularly promising are the N00N states—entangled N-photon wavepackets delocalized between two different locations—which outperform coherent states in measurement sensitivity. However, these states are notoriously vulnerable to losses, making them difficult to both share them between remote locations and recombine in order to exploit interference effects. Here we address this challenge by utilizing the reverse Hong–Ou–Mandel effect to prepare a high-fidelity two-photon N00N state shared between two parties connected by a lossy optical medium. We measure the prepared state by two-mode homodyne tomography, thereby demonstrating that the enhanced phase sensitivity can be exploited without recombining the two parts of the N00N state. Finally, we demonstrate the application of our method to remotely prepare superpositions of coherent states, known as Schrödinger’s cat states.
Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies
Authors: Rennert Robert C. , Januszyk Michael , Sorkin Michael , Rodrigues Melanie , Maan Zeshaan N. , Duscher Dominik , Whittam Alexander J. , Kosaraju Revanth , Chung Michael T. , Paik Kevin , Li Alexander Y. , Findlay Michael , Glotzbach Jason P. , Butte Atul J. , Gurtner Geoffrey C. 
Published: June 2016

AbstractCurrent progenitor cell therapies have only modest efficacy, which has limited their clinical adoption. This may be the result of a cellular heterogeneity that decreases the number of functional progenitors delivered to diseased tissue, and prevents correction of underlying pathologic cell population disruptions. Here, we develop a high-resolution method of identifying phenotypically distinct progenitor cell subpopulations via single-cell transcriptional analysis and advanced bioinformatics. When combined with high-throughput cell surface marker screening, this approach facilitates the rational selection of surface markers for prospective isolation of cell subpopulations with desired transcriptional profiles. We establish the usefulness of this platform in costly and highly morbid diabetic wounds by identifying a subpopulation of progenitor cells that is dysfunctional in the diabetic state, and normalizes diabetic wound healing rates following allogeneic application. We believe this work presents a logical framework for the development of targeted cell therapies that can be customized to any clinical application.
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
Authors: Brinkman C. Colin , Iwami Daiki , Hritzo Molly K. , Xiong Yanbao , Ahmad Sarwat , Simon Thomas , Hippen Keli L. , Blazar Bruce R. , Bromberg Jonathan S. 
Published: June 2016

AbstractRegulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal migration and allograft protection. Treg LTαβ rapidly modulates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non-canonical NFκB signalling via LTβR. These results demonstrate a form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function and is a unique therapeutic focus for modulating suppression.
A foraminiferal δ18O record covering the last 2,200 years
Authors: Taricco Carla , Alessio Silvia , Rubinetti Sara , Vivaldo Gianna , Mancuso Salvatore 
Published: June 2016

AbstractThanks to the precise core dating and the high sedimentation rate of the drilling site (Gallipoli Terrace, Ionian Sea) we were able to measure a foraminiferal δ18O series covering the last 2,200 years with a time resolution shorter than 4 years. In order to support the quality of this data-set we link the δ18O values measured in the foraminifera shells to temperature and salinity measurements available for the last thirty years covered by the core. Moreover, we describe in detail the dating procedures based on the presence of volcanic markers along the core and on the measurement of 210Pb and 137Cs activity in the most recent sediment layers. The high time resolution allows for detecting a δ18O decennial-scale oscillation, together with centennial and multicentennial components. Due to the dependence of foraminiferal δ18O on environmental conditions, these oscillations can provide information about temperature and salinity variations in past millennia. The strategic location of the drilling area makes this record a unique tool for climate and oceanographic studies of the Central Mediterranean.
The brain imaging data structure, a format for organizing and describing outputs of neuroimaging experiments
Authors: Gorgolewski Krzysztof J. , Auer Tibor , Calhoun Vince D. , Craddock R. Cameron , Das Samir , Duff Eugene P. , Flandin Guillaume , Ghosh Satrajit S. , Glatard Tristan , Halchenko Yaroslav O. , Handwerker Daniel A. , Hanke Michael , Keator David , Li Xiangrui , Michael Zachary , Maumet Camille , Nichols B. Nolan , Nichols Thomas E. , Pellman John , Poline Jean-Baptiste , Rokem Ariel , Schaefer Gunnar , Sochat Vanessa , Triplett William , Turner Jessica A. , Varoquaux Gaël , Poldrack Russell A. 
Published: June 2016

AbstractThe development of magnetic resonance imaging (MRI) techniques has defined modern neuroimaging. Since its inception, tens of thousands of studies using techniques such as functional MRI and diffusion weighted imaging have allowed for the non-invasive study of the brain. Despite the fact that MRI is routinely used to obtain data for neuroscience research, there has been no widely adopted standard for organizing and describing the data collected in an imaging experiment. This renders sharing and reusing data (within or between labs) difficult if not impossible and unnecessarily complicates the application of automatic pipelines and quality assurance protocols. To solve this problem, we have developed the Brain Imaging Data Structure (BIDS), a standard for organizing and describing MRI datasets. The BIDS standard uses file formats compatible with existing software, unifies the majority of practices already common in the field, and captures the metadata necessary for most common data processing operations.
A collection of intrinsic disorder characterizations from eukaryotic proteomes
Authors: Vincent Michael , Schnell Santiago 
Published: June 2016

AbstractIntrinsically disordered proteins and protein regions lack a stable three-dimensional structure under physiological conditions. Several proteomic investigations of intrinsic disorder have been performed to date and have found disorder to be prevalent in eukaryotic proteomes. Here we present descriptive statistics of intrinsic disorder features for ten model eukaryotic proteomes that have been calculated from computational disorder prediction algorithms. The data descriptor also provides consensus disorder annotations as well as additional physical parameters relevant to protein disorder, and further provides protein existence information for all proteins included in our analysis. The complete datasets can be downloaded freely, and it is envisaged that they will be updated periodically with new proteomes and protein disorder prediction algorithms. These datasets will be especially useful for assessing protein disorder, and conducting novel analyses that advance our understanding of intrinsic disorder and protein structure.
Experimental and Theoretical Investigation of Multispecies Oral Biofilm Resistance to Chlorhexidine Treatment
Authors: Shen Ya , Zhao Jia , de la Fuente-Núñez César , Wang Zhejun , Hancock Robert E. W. , Roberts Clive R. , Ma Jingzhi , Li Jun , Haapasalo Markus , Wang Qi 
Published: June 2016

AbstractWe investigate recovery of multispecies oral biofilms following chlorhexidine gluconate (CHX) and CHX with surface modifiers (CHX-Plus) treatment. Specifically, we examine the percentage of viable bacteria in the biofilms following their exposure to CHX and CHX-Plus for 1, 3 and 10 minutes, respectively. Before antimicrobial treatment, the biofilms are allowed to grow for three weeks. We find that (a). CHX-Plus kills bacteria in biofilms more effectively than the regular 2% CHX does, (b). cell continues to be killed for up to one week after exposure to the CHX solutions, (c). the biofilms start to recover after two weeks, the percentage of the viable bacteria recovers in the 1 and 3 minutes treatment groups but not in the 10 minutes treatment group after five weeks and the biofilms fully return to the pretreatment levels after eight weeks. To understand the mechanism, a mathematical model for multiple bacterial phenotypes is developed, adopting the notion that bacterial persisters exist in the biofilms together with regulatory quorum sensing molecules and growth factor proteins. The model reveals the crucial role played by the persisters, quorum sensing molecules and growth factors in biofilm recovery, accurately predicting the viable bacterial population after CHX treatment.
Comprehensive analysis of multi-tissue transcriptome data and the genome-wide investigation of GRAS family in Phyllostachys edulis
Authors: Zhao Hansheng , Dong Lili , Sun Huayu , Li Lichao , Lou Yongfeng , Wang Lili , Li Zuyao , Gao Zhimin 
Published: June 2016

AbstractGRAS family is one of plant specific transcription factors and plays diverse roles in the regulation of plant growth and development as well as in the plant disease resistance and abiotic stress responses. However, the investigation of GRAS family and multi-tissue gene expression profiles still remains unavailable in bamboo (Phyllostachys edulis). Here, we applied RNA-Seq analysis to monitor global transcriptional changes and investigate expression patterns in the five tissues of Ph. edulis, and analyzed a large-scale transcriptional events and patterns. Moreover, the tissue-specific genes and DEGs in different tissues were detected. For example, DEGs in panicle and leaf tissues were abundant in photosynthesis, glutathione, porphyrin and chlorophyll metabolism, whereas those in shoot and rhizome were majority in glycerophospholipid metabolism. In the portion of Ph. edulis GRAS (PeGRAS) analyses, we performed the analysis of phylogenetic, gene structure, conserved motifs, and analyzed the expression profiles of PeGRASs in response to high light and made a co-expression analysis. Additionally, the expression profiles of PeGRASs were validated using quantitative real-time PCR. Thus, PeGRASs based on dynamics profiles of gene expression is helpful in uncovering the specific biological functions which might be of critical values for bioengineering to improve bamboo breeding in future.