bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postural Heart Rate Changes in Young Patients With Vasovagal Syncope
Authors: Medow Marvin S. , Merchant Sana , Suggs Melissa , Terilli Courtney , O’Donnell-Smith Breige , Stewart Julian M. 
Published: March 2017

BACKGROUND AND OBJECTIVES:
Recurrent postural vasovagal syncope (VVS) is caused by transient cerebral hypoperfusion from episodic hypotension and bradycardia; diagnosis is made by medical history. VVS contrasts with postural tachycardia syndrome (POTS), defined by chronic daily symptoms of orthostatic intolerance with excessive upright tachycardia without hypotension. POTS has recently been conflated with VVS when excessive tachycardia is succeeded by hypotension during tilt testing. We hypothesize that excessive tachycardia preceding hypotension and bradycardia is part of the vasovagal response during tilt testing of patients with VVS.

METHODS:
We prospectively performed head-up tilt (HUT) testing on patients with recurrent VVS (n = 47, 17.9 ± 1.1 y), who fainted at least 3 times within the last year, and control subjects (n = 15, 17.1 ± 1.0 y), from age and BMI-matched volunteers and measured blood pressure, heart rate (HR), cardiac output, total peripheral resistance, and end tidal carbon dioxide.

RESULTS:
Baseline parameters were the same in both groups. HR (supine versus 5 and 10 minutes HUT) significantly increased in control (65 ± 2.6 vs 83 ± 3.6 vs 85 ± 3.7, P &lt; .001) and patients with VVS (69 ± 1.6 vs 103 ± 2.3 vs 109 ± 2.4, P &lt; .001). HUT in controls maximally increased HR by 20.3 ± 2.9 beats per minute; the increase in patients with VVS of 39.8 ± 2.1 beats per minute was significantly greater (P &lt; .001). An increase in HR of ≥40 beats per minute by 5 and 10 minutes or before faint with HUT, occurred in 26% and 44% of patients with VVS, respectively, but not in controls.

CONCLUSIONS:
Orthostasis in VVS is accompanied by large increases in HR that should not be construed as POTS.
Movimento pela democracia: a luta política do PCdoB na imprensa alternativa durante o processo de redemocratização brasileira (1979)
Authors: Macedo Michelle Reis de 
Published: March 2017

A partir da segunda metade dos anos 1970, durante o processo de abertura política no Brasil, a imprensa alternativa assumiu um papel fundamental na criação de uma opinião pública antiditadura e na propagação de uma cultura de esquerda, ligada aos valores democráticos. Criado em 1975, o jornal Movimento atraiu, além de jornalistas sem espaços na grande imprensa, militantes de diversas correntes políticas, sobretudo do Partido Comunista do Brasil (PCdoB). Abandonando a estratégia da luta armada, parte daqueles que sobreviveram à repressão sentiram a necessidade de engajamento na luta política legal pelas liberdades democráticas e adotaram Movimento como porta-voz de suas demandas. A proposta, portanto, é refletir acerca das estratégias de luta de setores da esquerda brasileira pela democracia representativa através das páginas do jornal alternativo Movimento.
THE PERIPHERAL BLOOD LEUKOCYTES SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO CHANGE AMONGST CHILDREN WITH INFECTIOUS MONONUCLEOSIS
Authors: Kurtasova L. M. , Shakina N. A. , Ikkes L. A. 
Published: March 2017

Objective: to measure cell susceptibility of peripheral blood leukocytes to interferon-α2 in vitro at children during the acute period in 1 and 6 months after infectious mononucleosis caused by the Epstein–Barr virus. 47 children aged 4–6 years with moderately severe form of the disease in the acute period of infectious mononucleosis caused by the Epstein–Barr virus (EBV) were examined, as well as in 1 month (n = 17) and 6 months (n = 11) after the disease. The focus group consisted of 36 nearly healthy children. The cell susceptibility to interferon-α2 in vitro was determined by the method of Kurtasova L.M. et al. (2007). Chemiluminescence of blood leukocytes was studied by De Sole et al. (1983). The susceptibility change of peripheral blood leukocytes to interferon-α2 in vitro at children with infectious mononucleosis caused by Epstein–Barr virus in dynamics of the disease has been revealed. The expansion of the range of cell susceptibility to interferon-α2 in 6 months after the disease has been enclosed. The dependence of the susceptibility of peripheral blood leukocytes to interferon-α2 in vitro on the dose and the period of the disease has been fixed.
SEVERE INTESTINAL FAILURE IN A CHAGAS’S DISEASE PATIENT AFTER TOTAL COLECTOMY PLUS PARTIAL ILEECTOMY
Authors: Duarte Thaís Castro , Melo Fernanda Godoi , Santos-Júnior José Rodrigues , Moussa Marcel P. , De-Souza Daurea Abadia 
Published: March 2017

Introduction: To report the clinical course of a Chagas’s disease patient with severe intestinal failure after resection of the total colon and terminal ileum.Case Report: The patient underwent rectosigmoidectomy (of the sigmoid volvulus, December 2009) and total colectomy plus partial ileectomy (May 2011). Patient evolved with multiple hospitalizations caused by severe diarrhea (up to 23 stools/day), hydroelectrolyte disturbance and acute renal failure, severe protein-energy malnutrition [loss of 34.9% of usual body weight (uBW)], and multiple episodes of sepsis. Were prescribed parenteral nutrition solutions exclusively or concurrently with very small volumes (e.g., 40ml/day) of semi-elemental diet with low fat and high protein. After several weeks predetermined amounts of carbohydrate-rich foods (potatoes, rice, pasta, cassava), vegetables (chayote, carrots), low-fat meat, cream crackers, coconut water and fruit (watermelon, melon, banana) were progressively introduced. After 36 months, the patient was metabolically stable (BW=67.2 kg, weight recovery of 23.6 kg), with hydroelectrolytic balance. Due to the recovery of the functional capacity, the patient was advised to return to his work activities. Conclusions: Chagas’s disease patient submitted to intestinal resection may have severe intestinal failure and protein-energy malnutrition. Specialized nutritional therapy and clinical and laboratory monitoring by a multidisciplinary team, can contribute to better prognostic.
Factors affecting survival of women with breast cancer in King Fahad Medical City, Saudi Arabia
Authors: Abu Zaid Lamyaa Z. , Nuzhat Ayesha , Rafiqe Munazzah 
Published: March 2017

Background: Breast cancer is the most frequently diagnosed cancer among women in 140 of 184 countries worldwide. The association between breast cancer survival and socio-demographic and pathologic factors has been widely studied in the developed countries. But scarce data is available from Saudi Arabia. We aimed to determine the overall observed one year and three years survival rate of female breast cancer patients and to investigate the factors affecting survival rate. Methods: Retrospective data was collected from the cancer center registry at King Fahad Medical City (KFMC) that included all women diagnosed with breast cancer between 1st January 2011 till 31st December 2012 and were followed to 31st December 2015 (cut off point for follow-up). Kaplan-Meier analysis was done to assess overall survival. The factors affecting survival rate such as age, histological type, tumor grade at diagnosis, metastases and treatment options were investigated using log rank test and Cox regression analysis. Results: The overall observed survival probability of the study population at 1, and 3 years was 95%, and 85%, respectively. The 3 year survivals for the younger (≤40 years), 41-50 years and older (50+ years) patients were 83.9%, 90.6% and 80.6% respectively, the differences not reaching statistical significance. There were statistically significant associations between three year survival and histological type of tumour, laterality, metastases and type of treatment by the univariate analysis log rank test. Conclusions: One and three-year survival rate of breast cancer at KFMC was 96% and 85% respectively. Investigating the factors affecting survival rate is one of the most essential means of improving cancer prognosis.
Zrównoważony rozwój sektora rolnego na Ukrainie w kontekście strategii „Europa 2020”
Authors: Łopatynskyi Yurii M. 
Published: March 2017

W artykule omówiono podstawowe elementy zrównoważonego rozwoju sektora rolnego na przykładzie Ukrainy. Zaproponowano główne kierunki harmonizacji uwarunkowań zrównoważonego rozwoju w kontekście strategii „Europa 2020”.
Hospital Based Birth Defect Surveillance in a Tertiary Care Centre
Authors: Kumar MK Mohan , Vinodkumar M.S. , Indu , 
Published: March 2017

<div><p><em>According to WHO in 2010, an estimated 270000 deaths globally were attributable to congenital anomalies during first 28 days of life. In an effort to decrease the number of congenital anomalies worldwide, 63<sup>rd</sup> the WHO adopted a birth defects resolution. The aim was to prevent congenital anomalies and raise awareness about their effects. Hospital based surveillance was implemented in India in collaboration with WHO. Institute of Maternal and Child Health (IMCH), Govt. Medical College Kozhikode was selected from the state of Kerala. Aim of this study includes, monitor and detect clusters (outbreaks) of congenital anomalies among a defined population and refer affected infants to appropriate services in a timely manner. Out of 15519 live births and 409 still births during the period of one year from November 2015 to 2016, there were 123 newborns with selected external congenital anomalies. </em><em></em></p></div>
Pharmacological Characteristics Analysis of Two Molecular Structures
Authors: Zhao Bo , Wu Hualong 
Published: March 2017

Abstract
Each year a large number of new diseases were found worldwide, which requires the development of new drugs to cure these diseases. In this process, researchers need to do a lot of work to test the effectiveness of new drugs and side effects. Due to the intrinsic connection between the characteristics of compound and its molecular structure, methods of pharmaceutical theory are widely used in the analysis of the features of the drug. By calculating the chemical indices of drug molecular structure, scientists could learn the chemistry and pharmacy characteristics of the corresponding drugs. In this paper, from the theoretical perspective, we state the following conclusions: (1) the exact expression of generalized degree distance for starlike tree is determined; (2) the eccentricity related indices of hetrofunctional dendrimer are discussed. The results obtained have broad application prospects in the pharmaceutical sciences.
A Holistic Approach to Sustainable Operational Risk Assessments in E&P Industry
Authors: Laskar Sandipan 
Published: March 2017

Abstract
The oil and gas industry has long recognized the necessity of periodically revalidating operational risk assessments by performing Process Hazard Analyses (PHAs), such as Hazard and Operability Studies and What-if analyses. To be successful in creating a sustainable business in hazardous industries, organization need to collectively manage risk across their operations in a routine and efficient way. This requires a change in the dynamic between safety and productivity, where safety is not set against production and risk mitigation becomes an integral part of efficient and effective operations.CCPS has published a book which describes this work process titled Revalidating Process Hazard Analyses. However there is limited guidance for revalidating supplemental risk analyses. The objectives of performing periodic revalidations are to address the cumulative changes in risk that occur over time and to continuously improve our understanding of that risk.
The purpose of operational risk assessments are to identify and understand the hazards associated with the process being reviewed, to understand the potential resultant hazardous events, and to prevent those events by identifying all the potential routes to those events and ensuring that adequate safeguards are in place to mitigate their risk. The application of a suitable hazards evaluation methodology (e.g., Hazard and Operability [HAZOP], Failure Mode and Effect Analysis [FMEA], What If, Checklist) is a core process of the risk assessment. All of the most-used methodologies are ultimately just different ways of asking "What If" questions. The key to success is asking (and, of course, correctly answering) the "right" What If questions. This paper will look at how a variation on an old theme can significantly improve the likelihood of asking all of the right questions, in a way that capitalizes on the strengths of some of the other approaches while avoiding their weaknesses. The work process mentioned in this paper will be illustrated with actual field examples and case studies.
This paper will guide operation managers, Health and Safety (HS) managers, and risk assessment team in effective preparation before and during a risk assessment meeting thereby can reduce the total resources required and improve the overall efficiency. The work process furnishes a company with an effective tool for revalidating operational risk assessments and will provide a holistic and common mean of balancing risk against production at all levels of the operation.
Performance Framework for Evolving Sustainability Strategies
Authors: Moon F. , Theys S. O. 
Published: March 2017

Abstract
Evolutions of strategies require company wide commitment to obtain business objectives and targets. Integrating sustainability into business strategies can present challenges for execution because organizational capability beyond that which is necessary for usual operations is often required.
Organizational capability is at the root of successful realization of such goals but can be the weakest area for companies seeking to evolve sustainability performance. A proposed performance framework for evolving sustainability strategies that is built upon several maturity models drawn from the oil and gas industry safety journey, value creation and sustainability concepts is presented with examples that illustrate common practices in the industry and elsewhere. For the sustainability journey, a sustainability maturity model aimed toward cultural transformation is built upon multiple concepts discussed in the paper.
All-Natural Process for the Rapid Treatment and Recycling of Hydrocarbon-Contaminated Solid Wastes Offers a Cost-Saving and Environmentally-Green Solution for the Petroleum Industry
Authors: Miles Andrew R. 
Published: March 2017

Abstract

Objectives/Scope
The objective of the manuscript is to inform the audience of a recently-designed, all-natural and costsaving technology that utilizes an engineered process for the on-site treatment of hydrocarbon-contaminated wastes from pipeline or storage tank leaks and spills, as well as the recycling of drilling wastes, which result in not only the elimination of the hydrocarbon but also the full re-use of the contaminated mediums.

Methods, Procedures, Process
The main body of the manuscript will inform the audience of the purposeful steps undertaken in the onsite treatment and reclamation of solid hydrocarbon-contaminated wastes and associated liquids. It will include the specifics of the regulatory factors and environmental liabilities surrounding the handling of the wastes, the technology and treatment of the wastes through the introduction of naturally-occurring microbes, and the available uses of the medium once it has been fully recycled. It will also depict a cost comparison to traditional methods of waste remediation as well as a time comparison to alternate methods of bio-remediation.

Results, Observations and Conclusions
Through the use of data, gathered from demonstrated field experiences and the 100% success rate of documented onsite reclamation projects, the audience will understand how the application of this technology and flexible process results in lab-verified elimination of the hydrocarbon contamination from the waste medium, as well as where the recycled product is safely being re-used and the pertinent economic factors when employment of the technology and process is being considered.

Novel/Additive Information
As with many new technologies and processes, there are ancillary benefits with this engineered protocol that are very real, despite the fact they likely would not appear in an economic study. Because this process is completed in the field at the site of the contamination, the hauling and disposal that accompanies traditional handling and treatment methods is eliminated. Less hauling and disposal results in, among other things, less heavy-vehicle traffic on public and private roads as well as a better air quality (dust and combustion exhaust) in the surrounding area. Other potential applications of the technology and process, as well as the applicability to other topic areas (HSE Management, Health and Social Responsibility), will also be introduced.
Quantitative Analysis of High Pressure Hazards in Oil and Gas Field Operations
Authors: Feo Giuseppe , Williams Wesley C. 
Published: March 2017

Abstract
This paper will discuss a simplified quantitative method for calculating the human health impacts of failures during high-pressure fluid operations. The methodology ties catastrophic high-pressure failure energies to specific human impacts. The methods are then applied to specific hazard situations found in the oil and gas-operating environment through examples. Simplified graphical methods for standard field piping "iron" at common design pressures are presented. These methods should assist engineers and operators in performing rapid quantitative assessment of the high-pressure hazards to their operations.
Since there has already been rigorous study of TNT explosions, we implement a TNT equivalent model relating it to an equivalent potential explosion energy of a pipeline based on the volume of the gas it contains. With an equivalent TNT energy, we can implement scaled distances for respective thresholds of injury based on biological studies that have created pressure-duration curves related to survivability. Using these survivability curves based on the overpressure and impulse respectively, we have created safe standoff distances for pipelines with a specific diameter and length.
Since survivability of an explosion depends on both overpressure and impulse respectively, a literature review was executed to account for these differences between a high explosive such as TNT and a pipeline explosion. We conclude that the differing explosion factors (overpressure and impulse) in a pipeline explosion counteract each other so that in terms of potential injury, a TNT explosion would produce relatively similar results.
Another difference between the two respective types of explosions is that the geometry of a pipeline explosion is highly directional and must be considered since it is not perfectly spherical as the TNT equivalent model assumes. Nevertheless, the calculations of the graphs are conservative relative to a TNT explosion in terms of both potential energy since the energy equation used represents an upper boundary. Additionally, the same applies in terms of the energy available for the explosion of a pipeline since not all gas will be readily available for detonation. In effect, we are describing a very complex problem that could potentially have many different outcomes. Thus, the conservative assumptions will allow the application of engineering judgement in assessing the risk of potential injury in specific drilling scenarios.
Association between Monocyte Count and Risk of Incident CKD and Progression to ESRD
Authors: Bowe Benjamin , Xie Yan , Xian Hong , Li Tingting , Al-Aly Ziyad 
Published: March 2017

Background and objectives
Experimental evidence suggests a role for monocytes in the biology of kidney disease progression; however, whether monocyte count is associated with risk of incident CKD, CKD progression, and ESRD has not been examined in large epidemiologic studies.

Design, settings, participants, & measurements
We built a longitudinal observational cohort of 1,594,700 United States veterans with at least one eGFR during fiscal year 2004 (date of last eGFR during this period designated time zero) and no prior history of ESRD, dialysis, or kidney transplant. Cohort participants were followed until September 30, 2013 or death. Monocyte count closest to and before time zero was categorized in quartiles: quartile 1, >0.00 to ≤0.40 thousand cells per cubic millimeter (k/cmm); quartile 2, >0.40 to ≤0.55 k/cmm; quartile 3, >0.55 to ≤0.70 k/cmm; and quartile 4, >0.70 k/cmm. Survival models were built to examine the association between monocyte count and risk of incident eGFR<60 ml/min per 1.73 m2, risk of incident CKD, and risk of CKD progression defined as doubling of serum creatinine, eGFR decline ≥30%, or the composite outcome of ESRD, dialysis, or renal transplantation.

Results
Over a median follow-up of 9.2 years (interquartile range, 8.3–9.4); in adjusted survival models, there was a graded association between monocyte counts and risk of renal outcomes. Compared with quartile 1, quartile 4 was associated with higher risk of incident eGFR<60 ml/min per 1.73 m2 (hazard ratio, 1.13; 95% confidence interval, 1.12 to 1.14) and risk of incident CKD (hazard ratio, 1.15; 95% confidence interval, 1.13 to 1.16). Quartile 4 was associated with higher risk of doubling of serum creatinine (hazard ratio, 1.22; 95% confidence interval, 1.20 to 1.24), ≥30% eGFR decline (hazard ratio, 1.18; 95% confidence interval, 1.17 to 1.19), and the composite renal end point (hazard ratio, 1.19; 95% confidence interval, 1.16 to 1.22). Cubic spline analyses of the relationship between monocyte count levels and renal outcomes showed a linear relationship, in which risk was higher with higher monocyte count. Results were robust to changes in sensitivity analyses.

Conclusions
Our results show a significant association between higher monocyte count and risks of incident CKD and CKD progression to ESRD.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_03_27_St_Louis_VA.mp3
Conservación in vitro: una perspectiva para el manejo de los recursos fitogenéticos
Authors: Bonilla Morales Miguel Macgayver 
Published: March 2017

<p>Los recursos fitogenéticos comprenden la diversidad vegetal cultivada que tiene un valor real o potencial en la seguridad alimentaria de la humanidad.<br />Desde esta perspectiva, cada una de las especies que han presentado un proceso de domesticación tanto a nivel local o mundial, asociando<br />sus parientes silvestres, poseen un patrimonio genético invaluable. Por tal motivo, las especies cultivadas pueden beneficiarse mediante el flujo<br />genético de sus parientes en busca de resistencia a plagas y enfermedades, fitomejoramiento o material adaptado al cambio climático. De tal manera,<br />la conservación del germoplasma que posee una especie es prioridad para mantener la variabilidad genética inter e intra-especifica, así como la de<br />sus accesiones. Las estrategias de conservación ex situ, en campo, presentan el riesgo de pérdida por condiciones climáticas adversas, ataque de<br />agentes patógenos, altos costos asociados al manejo agronómico, preparación de terreno, insumos y dificultad del manejo e intercambio de material.<br />No obstante, las técnicas de cultivo de tejidos vegetales permiten mantener las plántulas en bancos de germoplasma in vitro, libres de patógenos,<br />en espacio reducido, a bajo costo y condiciones controladas que facilitan el manejo a corto y largo plazo de material vegetal, particularmente, de<br />especies con propagación vegetativa. Esta investigación tuvo como objetivo determinar los componentes claves para introducir especies cultivadas<br />y establecer bancos de germoplasma in vitro que faciliten el intercambio de material vegetal entre entidades y personas, para garantizar la conservación,<br />disponibilidad y uso de la diversidad genética obtenida por los cultivadores.</p>