bluuebunny/crossref_metadata_2025_split huggingface dataset:
The crystal structure of bis(3-oxo-1,3-diphenylprop-1-en-1-olato-κ
2
O:O′)-bis(1,4-dioxane-κ
1
O)nickel(II), C38H38O8Ni
Authors: Wei Fanzhi 
Published: September 2024

Abstract
C38H38O8Ni, orthorhombic, Cmc21 (no. 36), a = 19.0266(4) Å, b = 8.2409(2) Å, c = 21.4315(5) Å, V = 3,360.38(13) Å3, Z = 4, Rgt
(F) = 0.0406, wRref
(F
2) = 0.1058, T = 293 K.
Exploring the mechanism of genistein in treating hepatocellular carcinoma through network pharmacology and molecular docking
Authors: Wang Siliang , Chen Wenlian , Dong Changsheng , Wu Jia , Zheng Miaomiao , Ma Yushui , Xue Yuwen 
Published: September 2024

Abstract

Objectives
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, with treatment options limited and outcomes often poor, especially in advanced stages. This study explores the therapeutic potential of genistein, a soybean-derived isoflavone, on HCC using network pharmacology to uncover its multi-targeted anti-cancer mechanisms.

Methods
Potential targets of genistein were predicted using databases such as Super-PRED, PharmMapper, and SwissTargetPrediction. Abnormally expressed genes in HCC tissues were analyzed from TCGA and GEO datasets, with genes linked to the prognosis of HCC patients selected as potential therapeutic targets. GO and KEGG pathway enrichment analyses were conducted for both genistein’s targets and the HCC-related gene set. Key targets were identified through network analysis using Cytoscape software. Molecular docking was performed with Autodock to assess the binding affinity between genistein and these key targets. The therapeutic effects of genistein on HCC were validated through animal experiments and cell line studies.

Results
This study identified 343 potential targets for genistein in treating hepatocellular carcinoma (HCC). Analyses revealed enrichment in cell cycle regulation pathways through GO and KEGG assessments. Transcriptomic data from HCC datasets unveiled 184 potential therapeutic targets, emphasizing cell cycle regulation. Notably, 12 proteins were identified as targets of both genistein and HCC treatment. Molecular docking studies demonstrated genistein’s strong binding affinity with CDC25C and MELK. In vitro and in vivo validations affirmed genistein’s role in inhibiting HCC proliferation by inducing G2/M phase arrest. This study elucidates genistein’s multi-target mechanism in suppressing HCC cell proliferation, supporting its potential clinical application in HCC treatment.

Conclusions
This study demonstrates that genistein effectively suppresses the malignant growth of HCC by interfering with the transition from the G2 to M phase, revealing a multifaceted mechanism of action.
Radiochemical separation of 161 Tb from neutron irradiated Gd target by liquid-liquid extraction technique
Authors: Shahr El-Din Ahmed M. , Gizawy Mohamed A. , Borai Emad H. 
Published: September 2024

Abstract
No-carrier-added (NCA) 161 Tb, which has advisable nuclear properties to be applied for cancer radiotherapy was produced at the Egyptian Second Research Reactor (ETRR-2) by neutron irradiation of natural gadolinium target via indirect nuclear reaction. The radiochemical separation of 161 Tb from irradiated gadolinium target was investigated based on solvent extraction technique using Cyanex 302. Several separation parameters were checked and optimized. According to the obtained results, the separation process of the investigated radioisotopes proceeds in two steps. The first step is an extraction of all of them into the organic phase in which the extraction % (98 %) was optimized at pH 4, 0.15 M of Cyanex 302 and 2.5 h extraction time. Moreover, the slope analysis method confirmed the participation of 2 mol of the organic extractant for the separation of 161 Tb from irradiated gadolinium. The second step is the separation of the 161 Tb isotope that was purified by the stripping of 159Gd with a citrate solution at pH 9, which is considered as a highly efficient and promising method for separation and purification of the two radioisotopes.
Aproximación geomecánica usando velocidades de onda y su relación con el parámetro “b”
Authors: Espinoza Peter 
Published: September 2024

In this research, an exhaustive and rigorous analysis about microseismicity and its importance for the analysis of geological structures will be presented, with special attention on the application of the GSI table and its relationship with safety. Microseismicity is the technique of detection and analysis of small seismic events that occur during the advance and mining exploitation, and its study is fundamental to guarantee a safe and efficient operation. The presence of these seismic events indicates the existence of stresses and deformations in the geological structures, which can have a significant impact on the safety of the operation. Therefore, microseismicity monitoring is an essential tool for geomechanical risk management. In this thesis the relationship between microseismicity and geological structures will be explored, using the GSI table as an important tool for the interpretation of microseismic data. The GSI table is a tool developed by the International Society for Rock Mechanics to assess the geomechanical stability of rock structures. In this work, the microseismic data will be analyzed and correlated with the GSI table, which will allow a better understanding of the geomechanical characteristics of the mine and a more accurate evaluation of geomechanical risk.
Simultaneous quantification of the main components of Thymus vulgaris essential oil in edible coating formed from nanocapsules using HS-SPME-GC-FID
Authors: González-Moreno Barbara Johana , Galindo-Rodríguez Sergio Arturo , Pérez-López Luis Alejandro , Portillo-Castillo Omar J. , Álvarez-Román Rocío 
Published: September 2024

AbstractThe use of edible coatings (ECs) containing essential oils (EOs), such as that derived from the Thymus vulgaris plant (EO-Tv), offers a natural option for preserving and increasing the shelf life of fruit and vegetable products. However, considering their physicochemical properties, the incorporation of EOs into nanocapsules (NCs) represents an alternative to reduce their volatility and oxidation. In this way, quantitative determination of the EOs incorporated into NCs is necessary for simultaneous monitoring of their main components during the nanoencapsulation process, as well as for the future precise and accurate dosage of EO components in fruit and vegetable products. In this study, ECs were formed from NCs loaded with EO-Tv and sodium alginate (AL). The EO-Tv was characterized through GC-MS and GC-FID analysis, and it was found that the major component of EO-Tv was thymol, with an abundance of 30.91%. Subsequently, an analytical method based on HS-SPME-GC-FID was developed and validated for quantification of the EO-Tv encapsulated in NCs and incorporated into the EC. The method was found to be precise and accurate for quantification of the main components of EO-Tv in the formed EC. Once the analytical method was validated, it was established that the encapsulation efficiency was greater than 50% in the case of NC-EO-Tv purified via evaporation at reduced pressure. On the other hand, 35.78 μg cm−2 of thymol was quantified in the EC formed from the NCs and AL. The present work presents an analytical tool for simultaneous quantification of the main components of EO-Tv in NCs, as well as in the ECs formed with NCs, promoting its potential application in fruit and vegetable products.
Effects of aerobic exercise at different intensities on articular cartilage in mice
Authors: He Chunxiao , Tsubaki Toshiya , Inoue Shota , Hatakeyama Junpei , Jiang Hanlin , Moriyama Hideki 
Published: September 2024

AbstractBackgroundMaintaining intrinsic articular cartilage homeostasis is essential for the health of cartilage. However, the impact of aerobic exercise of varying intensities on the articular cartilage homeostasis has never been studied. This study aims to elucidate the influence of different aerobic exercise intensities on the anabolic and catabolic processes within articular cartilage.MethodsForty-eight male C57BL/6J mice, aged 7 weeks, were divided into 4 aerobic exercise groups and 1 control group. The aerobic exercise groups were subjected to both acute and chronic exercise protocols with varying intensities of 8, 12, 16, 20, and 24 m min−1. Total RNA from the knee joint cartilage was extracted in both phases to quantify mRNA of anabolic (Sox9, Col2a1, and Acan) and catabolic (MMP-13 and ADAMTS5) markers. In the chronic exercise, articular cartilage thickness and chondrocyte density were histologically assessed. Additionally, immunohistochemical staining quantified relevant molecules involved in cartilage metabolism.ResultsIn the acute exercise, the 8 m min−1 group exhibited reduced ADAMTS5 expression compared to the control, 16 m min−1, and 24 m min−1 groups. Chronic exercise showed enhanced articular cartilage thickness in both the 8 and 12 m min−1 groups relative to the control group. Moreover, the 8 m min−1 group demonstrated elevated aggrecan levels in comparison to both the control and 24 m min−1 groups. Additionally, the 24 m min−1 group exhibited significantly higher ADAMTS5 levels than the control group.ConclusionOur findings suggest that consistent low-intensity aerobic exercise suppresses catabolic molecule expression in articular cartilage, thereby fostering anabolic activity. Conversely, continuous high-intensity aerobic exercise can potentially disrupt cartilage homeostasis by enhancing catabolic processes. This dichotomy underscores the need for balanced exercise regimens to maintain cartilage health.
IMPACTOS DAS ATIVIDADES ANTRÓPICAS NA COMUNIDADE MANGUEIRA, TERRA INDÍGENA ARAÇÁ EM AMAJARÍ - RORAIMA
Authors: Souza Jacqueline Gomes de Melo Benicio , Falcão Márcia Teixeira , Gomide Plínio Henrique Oliveira , Beserra Neta Luiza Câmara 
Published: September 2024

Atividades humanas têm provocado mudanças significativas em diversas regiões, especialmente em áreas habitadas por comunidades indígenas, onde o equilíbrio entre desenvolvimento e preservação ambiental é essencial. Este estudo tem como objetivo investigar os impactos das atividades antrópicas na Comunidade Indígena Mangueira, situada na Terra Indígena Araçá, em Amajari, Roraima. A pesquisa surge em um contexto onde as comunidades indígenas enfrentam crescentes pressões ambientais e socioeconômicas. Para realizar a pesquisa, obtivemos a devida autorização do Comitê de Ética em Pesquisa (CAAE nº 57979522.1.0000.5621). Foram conduzidas pesquisas in loco para identificar as principais formas de uso da terra, entrevistas com os moradores da comunidade e o uso de técnicas de geoprocessamento para mapeamento. Os resultados revelaram um processo significativo de desmatamento na comunidade Mangueira, causado por atividades como a introdução de novas áreas de cultivo, a retirada de madeira para construção de moradias e a substituição da vegetação nativa por espécies frutíferas. Embora essas alterações sejam moderadas e atendam às necessidades da população, a comunidade demonstra preocupação com esses impactos e discute soluções em assembleias comunitárias. A conscientização e a preocupação demonstradas pela comunidade são passos positivos, indicando um caminho promissor para a implementação de práticas que minimizem os danos ambientais enquanto atendem às necessidades da população local. Essas iniciativas são essenciais para garantir a sustentabilidade e a integridade ecológica da Terra Indígena Araçá em Roraima.
Certeza metafisica y certeza moral: una interpretación de la duda metódica cartesiana a partir de una distinción conceptual
Authors: Urrutia Soto Álvaro 
Published: September 2024

En las últimas décadas los especialistas de la filosofía cartesiana se han enfocado en indagar si la naturaleza de la duda metódica que el meditador instaura en la primera de las Meditaciones debe ser considerada como una preocupación sistemáticamente rigurosa o si, por el contrario, corresponde a un artificio que cumple un valor instrumental dentro del planteamiento que propone el autor, con la esperanza de que la respuesta a esta pregunta logre esclarecer el proceso que guía a las Meditaciones. Tanto quienes sostienen que la duda metódica es fingida como quienes piensan que, en algún sentido, debe ser considerada rigurosamente, recurren a una distinción conceptual advertida por el propio Descartes para validar sus respectivas lecturas, a saber: la distinción entre certeza metafísica y certeza moral. En el presente artículo se postula que la interpretación más apropiada es la que sostienen quienes consideran que la duda metódica guarda cierto nivel genuino de rigurosidad. Para justificar nuestra adhesión se evaluará el rendimiento explicativo de cada interpretación, tanto para el orden de desarrollo planteado en la primera meditación como para la aproximación a otros problemas filosóficos planteados en las Meditaciones.
Teacher Performance Supervision in International Elementary Schools: Principal Challenges
Authors: Triyadi Triyadi , Yusuf Munawir , Subagya Subagya 
Published: September 2024

Supervision conducted by school principals is an important element in improving the effectiveness of teaching and learning in schools. Through the supervision process, principals provide support, feedback and guidance that are essential for teachers' professional development. This collaborative approach to supervision that focuses on improving the quality of learning plays an important role in achieving the educational goals of the school. This study aims to describe and analyze the challenges faced by principals in conducting teacher performance supervision in international primary schools. This type of research is qualitative research with a narrative approach. Data were collected through observation, interviews, and document analysis of seven principals of international primary schools in Surakarta. The results of this study showed that principals in international primary schools face several challenges, including (1) the time of supervision; (2) communication; (3) the consistency of assessment; (4) perceptual differences; and (5) the skill for conducting supervision. This research provides an in-depth insight into the complexity of the principals’ challenges in conducting teacher performance supervision in international primary schools. This research is expected to help understand the dynamics of supervision in the international primary schools, which can be applied more broadly in improving teacher professionalism in the academic process.
Development of human digestive organ media based on Assemblr EDU
Authors: Yasa Arnelia Dwi , Kumala Farida Nur , Alfianto Rujian Nur Andi , Salimi Moh 
Published: September 2024

This study focuses on developing and evaluating a new learning media called Assemblr EDU-based human digestive organs media for elementary science learning. The motivation behind this research is the limitation of current learning materials, such as books and worksheets, which hinder students' understanding of the subject. The ADDIE development research model is employed, with 5th-grade students as the subjects. The study utilizes descriptive data analysis techniques and collects data through questionnaires using a Likert scale. The media is evaluated by material experts, media experts, linguists, teachers, and students. The results reveal that the media is considered feasible, with 88.5 percent of media experts rating it as "Very Feasible," 90 percent of material experts evaluating it as "Very Feasible," and 62.5 percent of linguists considering it as "Feasible." Furthermore, a practicality test conducted with teachers and students shows a 90 percent positive response. The effectiveness test, assessed through a t-test, demonstrates significant improvement in learning outcomes. Overall, the Assemblr EDU-based human digestive organ media proves feasible, practical, and effective in enhancing learning in elementary science. AbstrakKeterbatasan media pembelajaran khususnya pada pembelajaran IPA yang hanya menggunakan buku dan LKS saja tentang organ pencernaan manusia menyebabkan siswa kurang memahami materi yang disampaikan, sehingga pengembangan media pembelajaran perlu dilakukan. Tujuan penelitian ini untuk mendeskripsikan pengembangan media alat pencernaan manusia berbasis Assemblr EDU pada pembelajaran IPA SD serta mengetahui kelayakan, kepraktisan dan keefektifan media tersebut. Penelitian ini menggunakan model penelitian pengembangan ADDIE dengan subjek penelitian kelas 5 Sekolah Dasar. Penelitian ini menggunakan teknik analisis data deskriptif, dengan angket menggunakan skala likert oleh ahli materi, ahli media, ahli bahasa, serta respon guru dan siswa untuk pengumpulan data. Berdasarkan analisis data, hasil penelitian menunjukkan validasi ahli media menilai penggunaan media ini layak digunakan dengan hasil akhir 88,5 persen dinilai “Sangat Layak”, validasi ahli materi 90 persen dinilai “Sangat Layak”, dan validasi ahli bahasa 62,5 persen dinilai “Layak”. Sedangkan, uji praktikalitas diperoleh dari angket respon guru dan siswa mencapai 90 persen. Uji efektivitas yang dinilai melalui uji-t menunjukkan peningkatan hasil belajar yang signifikan. Media organ pencernaan manusia berbasis Assemblr EDU pada pembelajaran IPA SD layak, praktis dan efektif dalam meningkatkan pembelajaran.Kata Kunci: Assemblr EDU; organ pencernaan manusia; IPA
Ende-zu-Ende gedacht
Authors: Handke Florian , Bohara Rohit , Harig Alexander , Isaak Dominik , Jan Pelzl Jan Pelzl , Philipp Andreas , Priesterjahn Claudia , Schwinne Christian 
Published: September 2024

Die Anforderungen an die IT-Sicherheit von Maschinen und Anlagen werden fortlaufend komplexer. Dadurch wird die Verwendung von Maschinenidentitäten immer wichtiger. Sie spielen eine entscheidende Rolle beim Aufbau der IT-Sicherheit in industriellen Netzwerken. Maschinenidentitäten ermöglichen die Herstellung von Vertrauen zwischen Herstellern und Betreibern, z. B. durch den Nachweis der Herkunft von Komponenten und die Schaffung einer sicheren Rückverfolgbarkeit. Allerdings ist es aktuell noch schwierig, digitale Identitäten in industriellen Umgebungen einzuführen und zu verwalten. Die Inbetriebnahme, verbunden mit einer erstmaligen sicheren Integration der Geräte in das Netzwerk (Onboarding), ist dabei ein besonders kritischer Schritt. In diesem Artikel gehen wir auf die Bedeutung digitaler Identitäten für Komponenten ein, beschreiben notwendige Lösungsansätze wie das sichere Onboarding und geben mit unserem Forschungsprojekt Trustpoint ein Beispiel, wie eine sichere Verwaltung von digitalen Identitäten in der Industrie funktionieren kann.
Cave Levels in the Totes Gebirge (Eastern Alps)
Authors: Rummler Lina , Plan Lukas , Hauser Xenia 
Published: September 2024

Abstract
The Totes Gebirge is not only the largest karst massif in the Northern Calcareous Alps, it also contains the most cave passages. In this area we are investigating the vertical distribution of phreatic cave passages to determine cave levels. These are vertical zones with clusters of cave passages that can be correlated with former valley floors. Since only phreatic cave passages (i.e. caves that were permanently or episodically filled with water during their formation) are to be analysed, a genetic classification is made on the basis of field observations, cave maps, 3D surveys and descriptions.
As of Sept. 2023, the Totes Gebirge range, including the adjacent Warscheneck and the Hohe Schrott, contains 3172 known caves with a total length of 821 km, including the two longest cave systems in Austria, the Schönberg- (156 km) and the Schwarzmooskogel-Höhlensystem (137 km). As small caves do not contribute significantly to these statistics, only caves ≥50 m were included. The remaining 754 caves have a total length of 790 km. Only 46 % of these caves are at least partially of phreatic origin, but they contain 92 % of the total passage length. After subtracting the caves from which no data were available and cave sections that are not phreatic in origin (i.e. vadose or those created by weathering and erosion), 641 km of cave sections remained, which were analysed for their vertical distribution in 25 m increments.
The histogram of cave length distribution vs. elevation for the Totes Gebirge range shows only a single significant cluster of phreatic cave sections between 1300 and 1850 m above see level (a.s.l.), with a clear maximum at 1500 m. The massif was divided into four sub-regions and all of them show this main interval, which is why it was interpreted as a cave level. It correlates well with the Giant Cave Level known from all other karst massifs in the Northern Calcareous Alps analysed so far. However, it is peculiar that in the other massifs at least three cave levels are present. Other reasons, such as the lack of known caves and the large size of the massif, which could lead to overlapping of cave levels, are unlikely. Therefore, it seems possible that the palaeo surface drainage pattern around the Totes Gebirge or its uplift history was different from the other karst massifs in the Northern Calcareous Alps and that low-lying cave levels (Spring and Berger Cave Level) or an elevated one (Ruin Cave Level) did not develop. For each of the 21 largest cave systems (≥5 km in length), the peak of the vertical distribution of the phreatic passages was determined. Vectors were calculated in order to test whether palaeo-flow directions could be inferred from their distribution. These phreatic maxima indicate a general dip from ESE to WNW, which could be interpreted either as a palaeo-drainage direction or as a tectonic tilting of the whole massif after the formation of the passages.
Awareness about clear aligner among dental students- Cross sectional study
Authors: Daniel Jibin Joy 
Published: September 2024

To assess the awareness about clear aligner among dental students of first year, second year, third year, final year and interns of Pushpagiri College Of Dental Science.A cross-sectional questionnaire study conducted among Dental Students of Pushpagiri College of Dental Sciences, by collecting data using questionaire. Students of first year, second year, third year, final year and interns were included for the study. A questionnaire composed of 10 questions, designed to assess awareness about clear aligner among students. Fifty students participated in the study.The study reveals that out of fifty attendees – I)83.3% attendees didn’t used clear aligner before II) 91.7% of attendees aware about clear aligner III)83.3% attendees knows in which cases Invisalign can be use IV)83.3% attendees knows clear aligner have better oral hygiene than traditional brackets. Awareness program regarding clear aligner are necessary to create awareness among dental students.