bluuebunny/crossref_metadata_2025_split huggingface dataset:
An enhanced user authentication solution for mobile payment systems using wearables
Authors: Wong Kok‐Seng , Kim Myung Ho 
Published: October 2016

AbstractAs technology continues to evolve, banks and other enterprises are restructuring their businesses to provide services to customers anywhere and anytime. However, it is challenging to move from conventional payment systems toward digital wallets across a range of payment services. Mobile devices are easily lost or stolen, so the rapid adoption of mobile devices for payment systems requires protection against unauthorized access to private applications and data. When mobile devices communicate with merchant point‐of‐sale systems, there is a risk of data leakage because third party applications in point‐of‐sale systems might access private data stored on the device without the user's knowledge or permission. We thus propose the use of wearable devices to store partial private data for the user and to participate in the user authentication. In this paper, we design a practical user authentication solution for mobile payment systems, and the main idea is to split the user's private data, such as credit card and banking information, and then store them across two separate devices (e.g., a smartphone and a wearable device). Our solution can improve the security of existing mobile payment systems that utilize user biometrics as an authentication factor, such as Apple Pay and Samsung Pay. Copyright © 2016 John Wiley & Sons, Ltd.
A more secure and privacy‐aware anonymous user authentication scheme for distributed mobile cloud computing environments
Authors: Amin Ruhul , Islam SK Hafizul , Biswas G.P. , Giri Debasis , Khan Muhammad Khurram , Kumar Neeraj 
Published: October 2016

AbstractNow‐a‐days, the low‐power handheld mobile devices make our life more comfortable. With the fast advancement of mobile communication technologies and Internet, mobile users are accessing remote services at home over the Internet. Recently, Tsai and Lo put forwarded a user authentication scheme for distributing mobile cloud environments. Unfortunately, we observed that Tsai and Lo's scheme suffers from user impersonation attack and known session‐specific temporary information attack. Besides, the scheme does not support the wrong password and fingerprint detection in the authentication phase. The scheme also violates the user anonymity property. Moreover, the password update functionality is absent in Tsai and Lo's scheme. In order to provide more securities and functionalities, this article put forwarded an enhanced scheme for distributing mobile cloud environments. The simulation on automated validation of Internet security protocols and applications tool ensures that our scheme is secure against the active and passive attacks. Our cryptanalysis gives surety that the scheme can defend related security attacks. We also compare our scheme with the previous schemes with respect to computation cost and security aspects. Copyright © 2016 John Wiley & Sons, Ltd.
Tumores glómicos en el miembro superior. Revisión de la literatura e informe de 14 casos
Authors: Barreiro G. , Bestilleiro A. , del Castillo F. , Martel R.M. , García J. , Loureda R. 
Published: October 2016

Objetivo: Revisar los resultados del tratamiento quirúrgico de los tumores glómicos del miembro superior tratados en nuestro servicio de cirugía de la mano en los últimos 15 años y comparar con la bibliografía especializada los datos de una serie de 14 tumores operados.Material y método: Se trataron 14 tumores glómicos en 14 pacientes: 7 hombres y 7 mujeres. La media de edad fue de 50,7 años (rango 31-70).En todos los pacientes se anotó la zona de presentación del tumor, su aspecto macroscópico con registro fotográfico, la técnica quirúrgica y el resultado final, funcional y estético.Resultados: En todos los pacientes se dieron presentaciones únicas y todos se curaron completamente con el tratamiento quirúrgico, pero en 2 hubo recidivas y uno de ellos debió operarse hasta 5 veces para erradicar el tumor completamente.Conclusión: El tumor glómico, por su infrecuencia, es poco conocido fuera del ámbito de la cirugía de la mano y de la dermatología, de ahí la demora en el diagnóstico que padecen buena parte de los pacientes. Los de presentación extradigital no suelen sospecharse y su diagnóstico lo aporta el estudio anatomopatológico.El tratamiento quirúrgico, consistente en la exéresis de la masa tumoral y el legrado de la cavidad ósea si la hay, es resolutivo en la mayor parte de los casos, si bien la tasa de recidivas es muy elevada, probablemente por haberse realizado una escisión incompleta.La complicación más frecuente es de tipo estético, por deformidades de la uña en los tumores de presentación subungueal.
Patients as Patches: Ecology and Epidemiology in Healthcare Environments
Authors: Lofgren Eric T. , Egizi Andrea M. , Fefferman Nina H. 
Published: October 2016

The modern healthcare system involves complex interactions among microbes, patients, providers, and the built environment. It represents a unique and challenging setting for control of the emergence and spread of infectious diseases. We examine an extension of the perspectives and methods from ecology (and especially urban ecology) to address these unique issues, and we outline 3 examples: (1) viewing patients as individual microbial ecosystems; (2) the altered ecology of infectious diseases specifically within hospitals; and (3) ecosystem management perspectives for infection surveillance and control. In each of these cases, we explore the accuracy and relevance of analogies to existing urban ecological perspectives, and we demonstrate a few of the potential direct uses of this perspective for altering research into the control of healthcare-associated infections.Infect Control Hosp Epidemiol. 2016;1507–1512
Comprehensive screening for immunodeficiency-associated vaccine-derived poliovirus: an essential oral poliovirus vaccine cessation risk management strategy
Authors: DUINTJER TEBBENS R. J. , THOMPSON K. M. 
Published: October 2016

SUMMARYIf the world can successfully control all outbreaks of circulating vaccine-derived poliovirus that may occur soon after global oral poliovirus vaccine (OPV) cessation, then immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) from rare and mostly asymptomatic long-term excretors (defined as ⩾6 months of excretion) will become the main source of potential poliovirus outbreaks for as long as iVDPV excretion continues. Using existing models of global iVDPV prevalence and global long-term poliovirus risk management, we explore the implications of uncertainties related to iVDPV risks, including the ability to identify asymptomatic iVDPV excretors to treat with polio antiviral drugs (PAVDs) and the transmissibility of iVDPVs. The expected benefits of expanded screening to identify and treat long-term iVDPV excretors with PAVDs range from US$0.7 to 1.5 billion with the identification of 25–90% of asymptomatic long-term iVDPV excretors, respectively. However, these estimates depend strongly on assumptions about the transmissibility of iVDPVs and model inputs affecting the global iVDPV prevalence. For example, the expected benefits may decrease to as low as US$260 million with the identification of 90% of asymptomatic iVDPV excretors if iVDPVs behave and transmit like partially reverted viruses instead of fully reverted viruses. Comprehensive screening for iVDPVs will reduce uncertainties and maximize the expected benefits of PAVD use.
Mental health literacy as a mediator in use of mental health services among older korean adults
Authors: Kim Young Sun , Rhee T. Greg , Lee Hee Yun , Park Byung Hyun , Sharratt Monica L. 
Published: October 2016

ABSTRACTBackground:Existing literature suggests that mental health literacy is positively associated with mental health services utilization. Despite an aging population that faces significant mental health concerns in Korea, the role of mental health literacy on mental health services utilization is not known among older adults in Korea. This study aimed to (1) identify whether mental health literacy mediates the association between population characteristics and mental health services utilization and (2) identify an optimal path model for mental health services utilization among Korean older adults.Methods:Using a cross-sectional survey with a quota sampling strategy, we collected and analyzed responses from 596 community-dwelling individuals ages 65 years and older. We used structural equation modeling (SEM) to estimate the effect of mental health literacy as a mediator.Results:When controlling for other relevant covariates in the optimal path model, mental health literacy mediated the relationships between three socio-demographic factors (education, general literacy, and health status) and mental health services utilization. The model fit index shows that the SEM fits very well (CFI = 0.92, NFI = 0.90, RMSEA = 0.07).Conclusions:Efforts to improve mental health literacy through community-based education programs may need to particularly target Korean older adults with the relevant socio-demographic characteristics to enhance their utilization of appropriate mental health services.
A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles
Authors: Bekdemir Ahmet , Stellacci Francesco 
Published: October 2016

AbstractNanomedicine requires in-depth knowledge of nanoparticle–protein interactions. These interactions are studied with methods limited to large or fluorescently labelled nanoparticles as they rely on scattering or fluorescence-correlation signals. Here, we have developed a method based on analytical ultracentrifugation (AUC) as an absorbance-based, label-free tool to determine dissociation constants (KD), stoichiometry (Nmax), and Hill coefficient (n),for the association of bovine serum albumin (BSA) with gold nanoparticles. Absorption at 520 nm in AUC renders the measurements insensitive to unbound and aggregated proteins. Measurements remain accurate and do not become more challenging for small (sub-10 nm) nanoparticles. In AUC, frictional ratio analysis allows for the qualitative assessment of the shape of the analyte. Data suggests that small-nanoparticles/protein complexes significantly deviate from a spherical shape even at maximum coverage. We believe that this method could become one of the established approaches for the characterization of the interaction of (small) nanoparticles with proteins.
Chromosome biorientation produces hundreds of piconewtons at a metazoan kinetochore
Authors: Ye Anna A. , Cane Stuart , Maresca Thomas J. 
Published: October 2016

AbstractHigh-fidelity transmission of the genome through cell division requires that all sister kinetochores bind to dynamic microtubules (MTs) from opposite spindle poles. The application of opposing forces to this bioriented configuration produces tension that stabilizes kinetochore–microtubule (kt–MT) attachments. Defining the magnitude of force that is applied to kinetochores is central to understanding the mechano-molecular underpinnings of chromosome segregation; however, existing kinetochore force measurements span orders of magnitude. Here we measure kinetochore forces by engineering two calibrated force sensors into the Drosophila kinetochore protein centromere protein (CENP)-C. Measurements of both reporters indicate that they are, on average, under ∼1–2 piconewtons (pNs) of force at metaphase. Based on estimates of the number of CENP-C molecules and MTs per Drosophila kinetochore and envisioning kinetochore linkages arranged such that they distribute forces across them, we propose that kinetochore fibres (k-fibres) exert hundreds of pNs of poleward-directed force to bioriented kinetochores.
Visualizing ferromagnetic domain behavior of magnetic topological insulator thin films
Authors: Wang Wenbo , Chang Cui-Zu , Moodera Jagadeesh S , Wu Weida 
Published: October 2016

AbstractA systematic magnetic force microscopy (MFM) study of domain behavior in thin films of the magnetic topological insulator Sb1.89V0.11Te3 reveals that in the virgin domain state, after zero-field cooling, an equal population of up and down domains occurs. Interestingly, the cooling field dependence of MFM images demonstrates that a small cooling magnetic field (approximately 5–10 Oe) is sufficient to significantly polarize the film despite the coercive field (HC) for these films being on the order of a tesla at low temperature. By visualizing the magnetization reversal process around HC of V-doped Sb2Te3, we observed a typical domain behavior of a ferromagnet, i.e., domain nucleation and domain wall propagation. Our results provide direct evidence of ferromagnetic behavior of the magnetic topological insulator, a necessary condition for a robust quantum anomalous Hall effect.
Nuclear receptor nhr-48 is required for pathogenicity of the second stage (J2) of the plant parasite Meloidogyne incognita
Authors: Lu Chao-Jun , Tian Bao-Yu , Cao Yi , Zou Cheng-Gang , Zhang Ke-Qin 
Published: October 2016

AbstractNuclear receptors (NRs) are a diverse class of transcription factors, which are involved in regulating a large number of physiological events in metazoans. However, the function of NRs is poorly understood in plant-parasitic nematodes. Here, members of the NR1J+K group of NRs in nematodes, including the free-living and plant parasites, were examined and phylogenetically analyzed. We found that the number of members of the NR1J+K group in plant-parasitic nematodes was less than that in the free-living nematodes, suggesting this reduction of NR1J+K group members in plant parasites maybe arose during the separation of the free-living and intermediately plant parasitic nematodes (Bursaphelenchus xylophilus). Interestingly, the DNA-binding domain (DBD) and ligand-binding domain (LBD) of NR1J+K members were separated into two gene locations in the plant parasites. Knockdown of Meloidogyne incognita WBMinc13296, the ortholog of Caenorhabditis elegans nhr-48 DBD, reduced infectivity, delayed development, and decreased reproductivity. J2 of M. incognita subjected to silencing of WBMinc13295, the orthologs of B. xylophilus nhr-48 LBD, exhibited developmental lag within the host and reduced reproductivity. This study provides new insights into the function of NRs and suggests that NRs are potential targets for developing effective strategies for biological control of plant-parasitic nematodes.
Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study
Authors: Zhu Linling , Zhang Yu , Liu Yifeng , Zhang Runjv , Wu Yiqing , Huang Yun , Liu Feng , Li Meigen , Sun Saijun , Xing Lanfeng , Zhu Yimin , Chen Yiyi , Xu Li , Zhou Liangbi , Huang Hefeng , Zhang Dan 
Published: October 2016

AbstractThis study was carried out to explore associations between assisted reproductive technology (ART) and maternal and neonatal outcomes compared with similar outcomes following spontaneously conceived births. We conducted a retrospective cohort study of pregnancies conceived by ART (N = 2641) during 2006–2014 compared to naturally conceived pregnancies (N = 5282) after matching for maternal age and birth year. Pregnancy complications, perinatal complications and neonatal outcomes of enrolled subjects were investigated and analysed by multivariate logistic regression. We found that pregnancies conceived by in vitro fertilization (IVF) were associated with a significantly increased incidence of gestational diabetes mellitus, gestational hypertension, preeclampsia, intrahepatic cholestasis of pregnancy, placenta previa, placental abruption, preterm premature rupture of membranes, placental adherence, postpartum haemorrhage, polyhydramnios, preterm labour, low birth weight, and small-for-date infant compared with spontaneously conceived births. Pregnancies conceived by intracytoplasmic sperm injection (ICSI) showed similar elevated complications, except some of the difference narrowed or disappeared. Singleton pregnancies or nulliparous pregnancies following ART still exhibited increased maternal and neonatal complications. Therefore, we conclude that pregnancies conceived following ART are at increased risks of antenatal complications, perinatal complications and poor neonatal outcomes, which may result from not only a higher incidence of multiple pregnancy, but also the manipulation involved in ART processes.
Strontium isotope evidence for a highly mobile population on the Pamir Plateau 2500 years ago
Authors: Wang Xueye , Tang Zihua , Wu Jing , Wu Xinhua , Wu Yiqun , Zhou Xinying 
Published: October 2016

AbstractArcheological researches have proposed arguments for human mobility and long-distance trading over the Eurasia before the Silk Roads. Here we utilize biologically available strontium isotope analysis to assess the extent of pre-Silk Road population movements and cultural communications across the Asian interior. From an early Iron Age cemetery (ca. 2500 yr B.P.) on the eastern Pamir Plateau, mean87Sr/86Sr ratios from 34 individuals display considerable isotopic variability, and 10 individuals are distinguished as migrants based on the local strontium isotope range of 0.710296–0.710572 defined by 12 ovicaprine bones. Comparison of the proportion (10/34) with the regional census data completed in 1909 A.D. (3% non-locals) suggests a highly migratory behavior on the plateau 2500 years ago. Furthermore, exotic mortuary objects, such as silk fabrics from eastern China and angular harp originated from the Near East, clearly demonstrate an interaction between different cultures on the plateau before the establishment of the Silk Road.
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase
Authors: Lewis-Ballester Ariel , Forouhar Farhad , Kim Sung-Mi , Lew Scott , Wang YongQiang , Karkashon Shay , Seetharaman Jayaraman , Batabyal Dipanwita , Chiang Bing-Yu , Hussain Munif , Correia Maria Almira , Yeh Syun-Ru , Tong Liang 
Published: October 2016

AbstractTryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) play a central role in tryptophan metabolism and are involved in many cellular and disease processes. Here we report the crystal structure of human TDO (hTDO) in a ternary complex with the substrates L-Trp and O2 and in a binary complex with the product N-formylkynurenine (NFK), defining for the first time the binding modes of both substrates and the product of this enzyme. The structure indicates that the dioxygenation reaction is initiated by a direct attack of O2 on the C2 atom of the L-Trp indole ring. The structure also reveals an exo binding site for L-Trp, located ~42 Å from the active site and formed by residues conserved among tryptophan-auxotrophic TDOs. Biochemical and cellular studies indicate that Trp binding at this exo site does not affect enzyme catalysis but instead it retards the degradation of hTDO through the ubiquitin-dependent proteasomal pathway. This exo site may therefore provide a novel L-Trp-mediated regulation mechanism for cellular degradation of hTDO, which may have important implications in human diseases.
Integrated analysis of bacterial and microeukaryotic communities from differentially active mud volcanoes in the Gulf of Cadiz
Authors: Coelho Francisco J. R. C. , Louvado António , Domingues Patrícia M. , Cleary Daniel F. R. , Ferreira Marina , Almeida Adelaide , Cunha Marina R. , Cunha Ângela , Gomes Newton C. M. 
Published: October 2016

AbstractThe present study assesses the diversity and composition of sediment bacterial and microeukaryotic communities from deep-sea mud volcanoes (MVs) associated with strike-slip faults in the South-West Iberian Margin (SWIM). We used a 16S/18S rRNA gene based pyrosequencing approach to characterize and correlate the sediment bacterial and microeukaryotic communities from MVs with differing gas seep regimes and from an additional site with no apparent seeping activity. In general, our results showed significant compositional changes of bacterial and microeukaryotic communities in sampling sites with different seepage regimes. Sediment bacterial communities were enriched with Methylococcales (putative methanotrophs) but had lower abundances of Rhodospirillales, Nitrospirales and SAR202 in the more active MVs. Within microeukaryotic communities, members of the Lobosa (lobose amoebae) were enriched in more active MVs. We also showed a strong correlation between Methylococcales populations and lobose amoeba in active MVs. This study provides baseline information on the diversity and composition of bacterial and microeukaryotic communities in deep-sea MVs associated with strike-slip faults.
A unique peptide deformylase platform to rationally design and challenge novel active compounds
Authors: Fieulaine Sonia , Alves de Sousa Rodolphe , Maigre Laure , Hamiche Karim , Alimi Mickael , Bolla Jean-Michel , Taleb Abbass , Denis Alexis , Pagès Jean-Marie , Artaud Isabelle , Meinnel Thierry , Giglione Carmela 
Published: October 2016

AbstractPeptide deformylase (PDF) is considered an excellent target to develop antibiotics. We have performed an extensive characterization of a new PDF from the pathogen Streptococcus agalactiae, showing properties similar to other known PDFs. S. agalactiae PDF could be used as PDF prototype as it allowed to get complete sets of 3-dimensional, biophysical and kinetic data with virtually any inhibitor compound. Structure-activity relationship analysis with this single reference system allowed us to reveal distinct binding modes for different PDF inhibitors and the key role of a hydrogen bond in potentiating the interaction between ligand and target. We propose this protein as an irreplaceable tool, allowing easy and relevant fine comparisons between series, to design, challenge and validate novel series of inhibitors. As proof-of-concept, we report here the design and synthesis of effective specific bacterial PDF inhibitors of an oxadiazole series with potent antimicrobial activity against a multidrug resistant clinical isolate.
Universal stress protein Rv2624c alters abundance of arginine and enhances intracellular survival by ATP binding in mycobacteria
Authors: Jia Qiong , Hu Xinling , Shi Dawei , Zhang Yan , Sun Meihao , Wang Jianwei , Mi Kaixia , Zhu Guofeng 
Published: October 2016

AbstractThe universal stress protein family is a family of stress-induced proteins. Universal stress proteins affect latency and antibiotic resistance in mycobacteria. Here, we showed that Mycobacterium smegmatis overexpressing M. tuberculosis universal stress protein Rv2624c exhibits increased survival in human monocyte THP-1 cells. Transcriptome analysis suggested that Rv2624c affects histidine metabolism, and arginine and proline metabolism. LC-MS/MS analysis showed that Rv2624c affects the abundance of arginine, a modulator of both mycobacteria and infected THP-1 cells. Biochemical analysis showed that Rv2624c is a nucleotide-binding universal stress protein, and an Rv2624c mutant incapable of binding ATP abrogated the growth advantage in THP-1 cells. Rv2624c may therefore modulate metabolic pathways in an ATP-dependent manner, changing the abundance of arginine and thus increasing survival in THP-1 cells.