bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational future time perspective and mental health problems across adolescence: Random‐intercept cross‐lagged panel analysis and alternative variations
Authors: Yang Yi , Obsuth Ingrid , Zhu Xinxin , Ribeaud Denis , Eisner Manuel , Murray Aja 
Published: October 2024

AbstractIntroductionAdolescence is a crucial developmental stage characterized by escalating mental health issues as well as an increasing awareness of future career possibilities. Occupational future time perspective has been shown to be a promotive factor for social functioning and mental health, and a component in evidence‐based clinical practices and randomized controlled trial intervention studies. However, it requires more rigorous and ecological corroboration from longitudinal analysis at the within‐person level.MethodsRandom intercept cross‐lagged panel models with several adjustments and sensitivity analyses were applied to the longitudinal data from the Zurich Project on the Social Development from Childhood to Adulthood (Zurich, Switzerland), to analyze how occupational future time perspective and psychological/neurodevelopmental outcomes (attention deficit hyperactivity disorder symptoms/externalizing/internalizing problems) covaried across ages 13 (N = 1365), 15 (N = 1446), and 17 (N = 1305) in the years 2016, 2018, and 2020, after controlling for sex (52% male), SES, and school type.ResultsA small effect was found in a random intercept cross‐lagged panel model whereby occupational future time perspective at age 15 predicted externalizing problems at age 17 (β = .146, p = .05, [95% CI = 0.000, 0.292]), and in a random intercept (contemporaneous) reciprocal panel model specification attention deficit hyperactivity disorder symptoms at age 17 were contemporaneously associated with occupational future time perspective at age 17 (β = −.310, p < .05, [95% CI = −0.580, −0.041]). No cross‐lagged associations were found to be robust across different model specifications/adjustments.ConclusionsThese findings suggest that improving occupational future time perspective may have limited impact on enhancing mental health, offering valuable insights for school‐based interventions. Further research and replication are necessary to confirm these results.
Exploiting News Analytics for Volatility Forecasting
Authors: Bodilsen Simon Tranberg , Lunde Asger 
Published: October 2024

ABSTRACTThis study investigates the potential of news sentiment in predicting stock market volatility. We augment traditional time series models of realized volatility with the sentiment of macroeconomic and firm‐specific news. Our results demonstrate that incorporating the sentiment of domestic macroeconomic news significantly improves volatility predictions for individual stocks and the S&P 500 Index. Notably, we find substantial enhancements in long‐horizon volatility predictions when including the sentiment of macroeconomic news in the regression models. In contrast, firm‐specific news sentiment shows only modest predictive power in the general framework. However, expanding the set of predictors to include the news count of firm‐specific news occurring overnight between two consecutive trading periods significantly improves one‐period‐ahead volatility forecasts.JEL Classification: C53, C55, C58, G14, G17
Association of Muscle Strength With All‐Cause Mortality in the Oldest Old: Prospective Cohort Study From 28 Countries
Authors: Andersen Lars Louis , López‐Bueno Rubén , Núñez‐Cortés Rodrigo , Cadore Eduardo Lusa , Polo‐López Ana , Calatayud Joaquín 
Published: October 2024

ABSTRACTBackgroundAgeing is associated with a gradual loss of muscle strength, which in the end may have consequences for survival. Whether muscle strength and mortality risk associate in a gradual or threshold‐specific manner remains unclear. This study investigates the prospective association of muscle strength with all‐cause mortality in the oldest old.MethodsWe included 1890 adults aged ≥ 90 years (61.6% women, mean age 91.0 ± 1.5 years) from 27 European countries and Israel participating in the Survey of Health, Ageing and Retirement in Europe (SHARE) study. Muscle strength was assessed using handgrip dynamometry (unit: kilogram). Using time‐varying Cox regression with restricted cubic splines, we determined the prospective association of muscle strength with mortality, controlling for age, sex, smoking, BMI, marital status, education, geographical region and self‐perceived health.ResultsOver a mean follow‐up of 4.2 ± 2.4 years, more than half of the participants died (n = 971, 51.4%). The mean handgrip strength was 20.4 ± 8.0 kg for all participants, with men (26.7 ± 7.5 kg) showing significantly higher strength than women (16.4 ± 5.4 kg) (p < 0.001). Using the median level of muscle strength as reference (18 kg), lower and higher levels were associated in a gradual and curvilinear fashion with higher and lower mortality risk, respectively. The 10th percentile of muscle strength (10 kg) showed a hazard ratio (HR) of 1.27 (95% CI 1.13–1.43, p < 0.001). The 90th percentile (31 kg) showed an HR of 0.69 (95% CI 0.58–0.82, p < 0.001). Stratified for sex, the median levels of muscle strength were 26 kg for men and 16 kg for women. The 10th percentile of muscle strength showed HRs of 1.33 (95% CI 1.10–1.61, p < 0.001) at 15 kg for men and 1.19 (95% CI 1.05–1.35, p < 0.01) at 10 kg for women. The 90th percentile of muscle strength showed HRs of 0.75 (95% CI 0.59–0.95, p < 0.01) at 35 kg for men and 0.75 (95% CI 0.62–0.90, p < 0.001) at 23 kg for women. Sensitivity analyses, which excluded individuals who died within the first 2 years of follow‐up, confirmed the main findings.ConclusionRather than a specific threshold, muscle strength is gradually and inversely associated with mortality risk in the oldest old. As muscle strength at all ages is highly adaptive to resistance training, these findings highlight the importance of improving muscle strength in both men and women among the oldest old.
Associations of fetal and infant growth patterns with behavior and cognitive outcomes in early adolescence
Authors: Gonçalves Romy , Gaillard Romy , Ferguson Kelly K. , Sammallahti Sara , Hillegers Manon H. , Steegers Eric A. P. , El Marroun Hanan , Jaddoe Vincent W. V. 
Published: October 2024

AbstractBackgroundFetal life and infancy might be critical periods for brain development leading to increased risks of neurocognitive disorders and psychopathology later in life. We examined the associations of fetal and infant weight growth patterns and birth characteristics with behavior and cognitive outcomes at the age of 13 years.MethodsPopulation‐based prospective cohort study from fetal life until adolescence. Pregnant women with a delivery date between April 2002 and January 2006 were eligible. Follow‐up measurements were available for 4716 children. Fetal weight was estimated in the second and third trimesters of pregnancy by ultrasonography. Infant weight was measured at birth and at 6, 12, and 24 months. Fetal and infant weight acceleration or deceleration were defined as a change in SD greater than 0.67 between time points. Total, internalizing and externalizing problems and attention‐deficit hyperactivity disorder (ADHD) symptoms were measured using Child Behavior Checklist (CBCL/6–18), autistic traits by the Social Responsiveness Scale (SRS) and intelligence quotient (IQ) by the Wechsler Intelligence Scale for Children‐Fifth Edition (WISC‐V).ResultsOne week longer gestational age at birth was associated with a −0.03 SDS (95% Confidence Interval (CI): −0.04, −0.01) lower total behavior problems score, a −0.02 SDS (95% CI: −0.04, −0.01) lower ADHD symptoms score. Also an increase in birth weight of 500 g was associated with a lower odds of having high externalizing problems (OR 0.92 (95% CI: 0.86, 0.98) and of having a low IQ score (OR 0.79 (95% CI: 0.71, 0.88). Compared to children with normal fetal and infant growth, those with accelerated fetal and infant growth had a 0.27 SDS higher IQ (95% Confidence Interval 0.11, 0.44).ConclusionsBoth fetal and infant weight development are associated with behavioral and cognitive outcomes in early adolescence. Follow‐up studies are needed to assess whether these associations link to later life mental health outcomes.
Interleukin‐6 transcripts up‐regulation in lymph nodes from unicentric and multicentric Castleman disease
Authors: Lucioni Marco , Morello Gaia , Cristinelli Caterina , Fraticelli Sara , Neri Giuseppe , Travaglino Erica , Minetto Marco , Antoci Francesca , Libretti Paolo , Gambacorta Marcello , Arcaini Luca , Tripodo Claudio , Paulli Marco 
Published: October 2024

AbstractIntroductionCastleman disease (CD) represents a spectrum of heterogeneous lymphoproliferative disorders sharing peculiar histopathological features, clinically subdivided into unicentric CD (UCD) and multicentric CD (MCD) and presenting with variable inflammatory symptoms. Interleukin (IL)‐6 and other cytokines play a major role in mediating CD inflammatory manifestations. Although the local microenvironment seems to be among the major sources of hypercytokinemia, the precise cellular origin of IL‐6 production in CD is still debated.MethodsA series of five nodal CD of different subtypes (one UCD, two idiopathic MCDs [iMCDs], one HIV‐negative human herpesvirus 8 (HHV8)‐associated MCD, and one HIV‐positive HHV8‐associated MCD) and a non‐CD reactive control were tested using RNAscope analysis and a dual in situ hybridization (ISH)/immunohistochemistry technique, in order to quantify IL‐6 expression and its spatial distribution. Quantitative analyses of in situ mRNA were performed on digitalized slides using the HISTOQUANT software (3DHISTECH) and differences between cases were evaluated by the Kruskal‐Wallis test.ResultsRNA‐ISH documented increased IL‐6 expression in all CD lymph nodes, independently from clinical and pathological subtypes, however, the highest levels were found in HHV8+ cases and statistically significant differences in IL‐6 expression were found only between HHV8+ MCD and control case. Dual RNA‐ISH for IL6 coupled with immunohistochemistry analysis showed that IL‐6 was overexpressed in CD31‐positive endothelial cells in 5/5 CD tested cases but not in the control case.ConclusionOur findings suggest that nodal IL‐6 expression seems to be significantly upregulated in HHV8+ MCD, but a trend toward increased nodal IL‐6 expression was noticed also in UCD and iMCD‐not otherwise specified. CD31+ endothelial cells probably represent one of the major sources of IL‐6 production in the nodal microenvironment.
Continuous Global Improvement of Human Papillomavirus (HPV) Genotyping Services: The 2022 and 2023 HPV LabNet International Proficiency Studies
Authors: Arroyo Mühr Laila Sara , Eklund Carina , Lagheden Camilla , Yilmaz Emel , Forslund Ola , Lilja Marina , Dillner Joakim 
Published: October 2024

AbstractThe International Human Papillomavirus (HPV) Reference Center launches annual global HPV genotyping proficiency panels to enhance the precision and international standardization of HPV genotyping services. This study aims to assess the proficiency levels achieved in the global HPV genotyping proficiency panels conducted in 2022 and 2023, and to evaluate trends in performance over time. The proficiency panels comprised 44 blinded samples each, including 40 samples containing various purified plasmids corresponding to HPV types combined with human DNA, plus four control samples (one negative control and three extraction controls). Proficiency required a sensitivity of 50 International Units (IU)/5 µL for HPV 16 and HPV 18 500 IU/5 µL for HPVs 6, 11, 31, 33, 45, 52, and 58 and 500 genome equivalents (GE)/5 µL for other HPV types in both single and multiple infections, while avoiding false positivity. In 2022, 78 laboratories submitted a total of 154 data sets, and in 2023, 81 laboratories contributed 141 data sets. Most data sets (87%, 258/295) utilized commercially available HPV assays. Proficiency was common, with 77% of data sets meeting the proficiency criteria in 2022 and 79% in 2023. False positive results significantly decreased from 22% in 2022 to 13% in 2023. The high proficiency and increasing specificity in HPV genotyping services indicates progress toward more reliable HPV testing. High accuracy is crucial for supporting global efforts in HPV and cervical cancer elimination.
Analysis of etched drain based Cylindrical agate‐all‐around tunnel field effect transistor based static random access memory cell design
Authors: Beohar Ankur , Mathew Ribu , Sarode Darshan , Upadhyay Abhishek Kumar , Khare Kavita 
Published: October 2024

AbstractThis paper aims to propose a novel method for designing an static random access memory (SRAM) cell using an etched drain based Cyl GAA TFET with a hetero‐substrate material and an elevated density strip. The aim is to reduce power dissipation and improve stability, as demonstrated through analysis utilizing static noise margin (SNM) as well as N‐curve methods. With respect to the 16 nm MOSFET based SRAM cell, the proposed device‐based SRAM cell shows significant improvements with a 68.305% reduction in leakage power, a 15.58% increase in static voltage noise margin (SVNM), an 8.623% increase in static current noise margin (SINM), an 8.152% increase in write trip voltage (WTV), a 12.86% increase in write trip current (WTI), a 27.62% increase in static power noise margin (SPNM), and a 19.95% increase in write trip power (WTP). The design is implemented and analyzed using Cadence Virtuoso software, and a novel approach of look up tables and Verilog A is utilized for the device to circuit application. These results indicate promising advancements in the design of SRAM cells, which could have significant implications for the development of advanced computer systems.
Pathogenicity of Bacillus subtilis Against Symbiotic Fungus of Euwallacea fornicates (Coleoptera: Scolytidae) From South India
Authors: Ashif Kammatterikunnu , Rabeesh Thattanteparambil 
Published: October 2024

ABSTRACTIn India, the shot‐hole borer, Euwallacea fornicates, commonly known as the tea borer, infests the galleries of tea plant twigs under natural conditions and is a major pest of tea. The current investigation focuses on the antagonistic ability of Bacillus subtilis to directly inhibit the growth of plant pathogens in two different climatic regions of tea‐growing area. The evaluation reveals that (a) B. subtilis can directly suppress the growth of plant pathogens (b) in the in vitro evaluation; the B. subtilis suppressed the growth of the Fusarium ambrossium, which is the nourishment for the ambrosia beetle, (c) it also revealed that the antagonistic microbes and the entomopathogens are able to control the pest population of the shot hole borer of tea. The impact of B. subtilis on mycelial growth, sporulation, and spore germination of F. ambrosium in agar medium was observed. In the field condition on the post‐treatment assessments shows an average decline of 40% in both foliar and soil drenching. Hence, we recommend the antagonistic bacterium B. subtilis for including as an IPM for the management of shot hole borer in tea.
Assessment of Lethal, Sublethal, Transgenerational, and Biochemical Effects of Isaria fumosorosea on Mythimna separata
Authors: Raza Mudasar , Freed Shoaib , Ahmed Rizwan , Naeem Afifa 
Published: October 2024

ABSTRACTMythimna separata is a destructive polyphagous pest of field crops. Insecticides are generally applied for its control which not only negatively affect natural enemies and the environment and cause resistance in the insect pests. There is a need for the friendly method which is safe for the environment and life. Currently, entomopathogenic fungi are being used as biological control agents for different insects. The influence of Isaria fumosorosea on survival, life table parameters, and enzymatic activities of M. separata were assessed. On the seventh day post‐treatment, the highest concentration 3 × 108 spores/mL−1 caused the 92.5% larval mortality. The effect of LC15 and LC50 of I. fumosorosea were recorded on parental generation (F0) and first filial generation (F1) of M. separata. The life table parameters of F1 showed a decreasing trend in the intrinsic rate (r), net reproductive rate (Ro), mean generational time (T), total larval duration, and fecundity ratio in treated groups. In LC15 and LC50, groups the average fecundity ratio was 319.2 and 191.18 eggs/female, respectively. The activities of detoxifying enzymes were concentration‐dependent and highest activities were recorded on the third day. I. fumosorosea negatively affected the growth parameters of M. separata and can be included in M. separata management program.
Compact Metasurface Terahertz Spectrometer
Authors: Ji Wenye , Chang Jin , Mirzaei Behnam , Ridder Marcel , Jellema Willem , Kao Tsung‐Yu , Lee Alan , Gao Jian Rong , Urbach Hendrik Paul , Adam Aurèle J. L. 
Published: October 2024

AbstractThe terahertz frequency region of the electromagnetic spectrum is crucial for understanding the formation and evolution of galaxies and stars throughout the universe's history, as well as the process of planet formation. Detecting the unique spectral signatures of molecules and atoms requires terahertz spectrometers, which must be operated in space observatories due to water vapor absorption in the Earth's atmosphere. However, current terahertz spectrometers face challenges such as low resolution, limited bandwidth, large volume, and complexity. In this paper, the issues of size and weight are addressed by demonstrating a concept for a centimeter‐sized, low‐weight terahertz spectrometer using a metasurface. The design of the metasurface spectrometer is first discussed for the 1.85 to 2.4 THz range, followed by its fabrication. Next, an array of quantum cascade lasers operating at slightly different frequencies around 2.1 THz is utilized to characterize the spectrometer. Finally, a spectrum inversion method is applied to analyze the measured data, confirming a resolution R (λ/Δλ) of at least 273. This concept can be extended to other application areas, such as planetary observations and various wavelengths in the far‐infrared (FIR) and near‐infrared (NIR) ranges.
Agency mode selection and software competition in supply chains
Authors: Ren Tinghai , Zeng Nengmin , Wang Dafei , Yuan Kaifu 
Published: October 2024

AbstractAt present, many software developers work with downstream service providers to sell software and services. For political or economic reasons, foreign developers may be not allowed to sell software and services directly in the country of providers, but they can authorize their software to the providers for sale. In this study, we examine two types of IT supply chain (ITSC), namely, “Agenting Domestic Software” (Mode 1) and “Agenting Foreign Software” (Mode 2), each with a domestic developer/a foreign developer, a service provider, and client enterprises. In both modes, clients can either pay a high price to purchase software with accessorial pre‐sale service from the provider, or firsthand acquire it from the domestic developer at a low price but without pre‐sale service. We observe that in Mode 1, the domestic developer's market scale and the competition intensity of software have no effect on the domestic developer's decisions and profit; however, they have influences on the provider's decisions and profit. In Mode 2, the profits of ITSC members may increase with the intensity of software competition. When the domestic developer's market scale is small (large), and the domestic developer has (loses) the advantage of low extended‐warranty‐service (EWS) cost, Mode 1 (2) is more beneficial to the domestic developer than Mode 2 (1); however, the provider is more willing to choose Mode 2 (Mode 1). In other cases, either Mode 1 or Mode 2 may result in a win‐win situation for the domestic developer and provider.
Six‐degrees‐of‐freedom pelvic bone monitoring on 2D kV intrafraction images to enable multi‐target tracking for locally advanced prostate cancer
Authors: Hewson Emily A , Dillon Owen , Poulsen Per R , Booth Jeremy T , Keall Paul J 
Published: October 2024

AbstractBackgroundPatients with locally advanced prostate cancer require the prostate and pelvic lymph nodes to be irradiated simultaneously during radiation therapy treatment. However, relative motion between treatment targets decreases dosimetric conformity. Current treatment methods mitigate this error by having large treatment margins and often prioritize the prostate at patient setup at the cost of lymph node coverage.PurposeTreatment accuracy can be improved through real‐time multi‐target adaptation which requires simultaneous motion monitoring of both the prostate and lymph node targets. This study developed and evaluated an intrafraction pelvic bone motion monitoring method as a surrogate for pelvic lymph node displacement to be combined with prostate motion monitoring to enable multi‐target six‐degrees‐of‐freedom (6DoF) tracking using 2D kV projections acquired during treatment.Material and methodsA method to monitor pelvic bone translation and rotation was developed and retrospectively applied to images from 20 patients treated in the TROG 15.01 Stereotactic Prostate Ablative Radiotherapy with Kilovoltage Intrafraction Monitoring (KIM) trial. The pelvic motion monitoring method performed template matching to calculate the 6DoF position of the pelvis from 2D kV images. The method first generated a library of digitally reconstructed radiographs (DRRs) for a range of imaging angles and pelvic rotations. The normalized 2D cross‐correlations were then calculated for each incoming kV image and a subset of DRRs and the DRR with the maximum correlation coefficient was used to estimate the pelvis translation and rotation. Translation of the pelvis in the unresolved direction was calculated using a 3D Gaussian probability estimation method. Prostate motion was measured using the KIM marker tracking method. The pelvic motion monitoring method was compared to the ground truth obtained from a 6DoF rigid registration of the CBCT and CT.ResultsThe geometric errors of the pelvic motion monitoring method demonstrated sub‐mm and sub‐degree accuracy and precision in the translational directions (, , ) and rotational directions (, , ). The 3D relative displacement between the prostate and pelvic bones exceeded 2, 3, 5, and 7 mm for approximately 66%, 44%, 12%, and 7% of the images.ConclusionsAccurate intrafraction pelvic bone motion monitoring in 6DoF was demonstrated on 2D kV images, providing a necessary tool for real‐time multi‐target motion‐adapted treatment.