bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Evaluation of Neem Mouthwash on Plaque and Gingivitis: A Double-blind Crossover Study
Authors: Dhanya RS , Adarsh VJ , Jalaluddin Md , Rajasekaran UB , Sudeep CB 
Published: August 2017

ABSTRACT

Aim
The present study aimed at evaluating the impact of neemcontaining mouthwash on plaque and gingivitis.

Materials and methods
This randomized, double-blinded, crossover clinical trial included 40 participants aged 18 to 35 years with washout period of 1 week between the crossover phases. A total of 20 participants, each randomly allocated into groups I and II, wherein in the first phase, group I was provided with 0.2% chlorhexidine gluconate and group II with 2% neem mouthwash. After the scores were recorded, 1-week time period was given to the participants to carry over the effects of the mouthwashes and then the second phase of the test was performed. The participants were instructed to use the other mouthwash through the second test phase.

Results
There was a slight reduction of plaque level in the first phase as well as in the second phase. When comparison was made between the groups, no statistically significant difference was seen. Both the groups showed reduction in the gingival index (GI) scores in the first phase, and there was a statistically significant difference in both groups at baseline and after intervention (0.005 and 0.01 respectively). In the second phase, GI scores were reduced in both groups, but there was a statistically significant difference between the groups only at baseline scores (0.01).

Conclusion
In the present study, it has been concluded that neem mouthwash can be used as an alternative to chlorhexidine mouthwash based on the reduced scores in both the groups.

Clinical significance
Using neem mouthwash in maintaining oral hygiene might have a better impact in prevention as well as pervasiveness of oral diseases as it is cost-effective and easily available.

How to cite this article
Jalaluddin M, Rajasekaran UB, Paul S, Dhanya RS, Sudeep CB, Adarsh VJ. Comparative Evaluation of Neem Mouthwash on Plaque and Gingivitis: A Double-blind Crossover Study. J Contemp Dent Pract 2017;18(7):567-571.
Assessment of the Effect of Orthodontic Treatment on the Periodontal Health of Endodontically Restored Tooth
Authors: Asnani Mohil M , Jalaluddin Md , Goyal Vinod , Naqvi Zuber A , Gupta Bhaskar , Sonigra Hitesh M 
Published: August 2017

ABSTRACT

Intorduction
Patients usually undergo orthodontic treatment for achieving ideal interocclusal relationship between the dental tissue and bony tissue along with improving the speech, mastication, and facial esthetic appearance. Literature quotes paucity in the studies evaluating the effect of orthodontic treatment on the periodontal health of endodontically treated teeth. Hence, we planned the present study to assess the effect of orthodontic treatment on the periodontal health of endodontically restored tooth.

Materials and methods
The present study included assessment of 80 patients who underwent orthodontic treatment. All the patients were divided broadly into two study groups: groups I and II. Group I included patients with the absence of endodontically treated teeth, while group II included patients which maxillary central incisors were resorted endodontically. Examination of the periodontal health of the patients was done using the community periodontal index of treatment need (CPITN) around the selected teeth. All the values were recorded during the preorthodontic time, postorthodontic time, and after the first 6 months of starting of the orthodontic treatment. All the results were recorded separately and analyzed.

Results
In the groups I and II, 28 and 25 patients respectively, had score of 1, while 10 patients in group I and 12 patients in group II had score of 2. Nonsignificant results were obtained while comparing the CPITN score in between the two study groups when measured at the pre-, intra-, and postortho time.

Conclusion
In patients undergoing orthodontic treatment, having endodontically resorted teeth, no difference exists in relation to the periodontal health.

Clinical significance
Orthodontic treatment can be safely carried in patients with endodontically restored teeth.

How to cite this article
Jalaluddin M, Goyal V, Naqvi ZA, Gupta B, Asnani MM, Sonigra HM. Assessment of the Effect of Orthodontic Treatment on the Periodontal Health of Endodontically Restored Tooth. J Contemp Dent Pract 2017;18(7):587-590.
Therapeutic Evaluation of Cervical Dysfunction in Patients with Myofascial Pain Dysfunction Syndrome: A Prospective Study
Authors: Jagdhari B Smriti , Mukta Motwani , Saket A Golhar , Golhar Anil V 
Published: August 2017

ABSTRACT

Aim
The aim of this study was to find out the therapeutic correlation between cervical dysfunction and myofascial pain dysfunction syndrome (MPDS).

Materials and methods
The study included 46 patients out of which 23 had MPDS with cervical pain (group I), and 23 patients had only MPDS (group II). Detailed history and examination of the patients were carried out, and the factors taken into consideration were pain and tenderness of muscles of mastication and neck muscles, maximum comfortable mouth opening, and cervical range of motion. All the patients were randomly divided and advised physical exercises, light amplification by stimulated emission of radiation (LASER) therapy, and the combination of both exercise and LASER. Patients were assessed for the relief of signs and symptoms of myofascial pain and cervical pain posttreatment, every month for 2 months.

Results
Both the groups showed a similar response to all the different treatment modalities. In group I, the patients also had relief in their cervical pain although the treatment was directed for MPDS. Patients from both the groups who were advised LASER and combination of both exercise and LASER showed better response in terms of reduction in visual analog scale, number of tender muscles, and increased maximum comfortable mouth opening posttreatment and during the follow-up, as compared with the patients who were advised only exercise.

Conclusion
Patients having cervical pain showed significant improvement comparable with patients having no cervical pain. Hence, the conclusion drawn was that there is a positive interrelationship between MPDS and cervical (neck) pain; MPDS may act as a catalyst for precipitating cervical pain.

Clinical significance
Cervical pain showed significant improvement to physiotherapy in the form of exercise, LASER, and combination treatment, though the effective modality was LASER and combination of exercise and LASER therapy.

How to cite this article
Jagdhari BS, Mukta M, Saket AG, Golhar AV. Therapeutic Evaluation of Cervical Dysfunction in Patients with Myofascial Pain Dysfunction Syndrome: A Prospective Study. J Contemp Dent Pract 2017;18(7):601-606.
Alteration in Taste Perception among Young Children during the use of Removable Orthodontic Appliance Therapy
Authors: Singh Smita , Goyal Vinod , Naqvi Zuber A , Razdan Priyanka , Sakthivel VS , Tripathi Swati 
Published: August 2017

ABSTRACTBackgroundThe sense of smell is very influential in the taste of foods. If the smell pleases us, we anticipate the taste of the food with a great deal of relish. If our sense of smell is impaired, so is our taste. The effect of appliance on taste perceptions has always had a controversial subject.Materials and methodsThe present study was designed to analyze the change in taste perception in children using removable orthodontic appliances. All the selected volunteers were given different taste stimuli and were asked to score as per their perception. The verbal score was calculated based on the correct and incorrect taste stimuli given to them. Visual analog scale was used to assess intensity and hedonic (palatability) estimation of the volunteers.ResultsThe volunteers from both study and control groups scored different values for taste stimuli. The majority of stimuli were estimated correctly by both groups. There was no statistically significant difference between the study and control groups.ConclusionIn different testing sessions, the scoring of the volunteers was nearly constant, indicating that an appliance does not play a major role in the alteration of taste stimuli.Clinical significanceThe appliance brings about transient change in taste perception, we should educate the patient before delivering the appliance about the transient change in taste perception and encourage full-time wear of the appliance, including during meals, without fear of affecting taste sensations.How to cite this articleRazdan P, Sakthivel VS, Naqvi ZA, Goyal V, Tripathi S, Singh S. Alteration in Taste Perception among Young Children during the use of Removable Orthodontic Appliance Therapy. J Contemp Dent Pract 2017;18(7):607-613.
Adhesive Bonding to Computer-aided Design/Computer-aided Manufacturing Esthetic Dental Materials: An Overview
Authors: Bhandi Shilpa H , Awad Mohamed Moustafa , Alqahtani H , Al-Mudahi A , Murayshed MS , Alrahlah A 
Published: August 2017

ABSTRACT

Aim
To review the adhesive bonding to different computer-aided design/computer-aided manufacturing (CAD/CAM) esthetic restorative materials.

Background
The use of CAD/CAM esthetic restorative materials has gained popularity in recent years. Several CAD/ CAM esthetic restorative materials are commercially available. Adhesive bonding is a major determinant of success of CAD/ CAM restorations.

Review result
An account of the currently available bonding strategies are discussed with their rationale in various CAD/ CAM materials.

Conclusion
Different surface treatment methods as well as adhesion promoters can be used to achieve reliable bonding of CAD/CAM restorative materials. Selection of bonding strategy to such material is determined based on its composition. Further evidence is required to evaluate the effect of new surface treatment methods, such as nonthermal atmospheric plasma and self-etching ceramic primer on bonding to different dental ceramics.

Clinical significance
An understanding of the currently available bonding strategies to CA/CAM materials can help the clinician to select the most indicated system for each category of materials.

How to cite this article
Awad MM, Alqahtani H, Al-Mudahi A, Murayshed MS, Alrahlah A, Bhandi SH. Adhesive Bonding to Computer-aided Design/Computer-aided Manufacturing Esthetic Dental Materials: An Overview. J Contemp Dent Pract 2017;18(7):622-626.
Clinical Efficacy and Safety of Punarnavadi Mandura and Dadimadi Ghrita in the Management of Iron Deficiency Anemia: A Prospective Open-label Multicenter Study
Authors: Sannd Rajesh , Meena HML , Das Banmali , Bhuyan GC , Padhi MM 
Published: August 2017

ABSTRACT

Background
Iron deficiency anemia is one of the most prevalent types of nutritional disorder in the world. Its etiology is multifaceted and it generally results when the iron demands of the body are not met by iron absorption. Iron deficiency anemia can be symptomatically compared with Pandu Roga in Ayurveda.

Aims and objectives
To evaluate the efficacy and safety of Punarnavadi Mandura and Dadimadi Ghrita in patients suffering from iron deficiency anemia.

Materials and methods
A prospective, open-label multicenter study was carried out at three peripheral centers of the Central Council for Research in Ayurvedic Sciences. One hundred three patients satisfying the selection criteria were enrolled from the outpatient department of these centers and were administered Punarnavadi Mandura (500 mg) and Dadimadi Ghrita (10 gm) twice daily before food with lukewarm water for 12 weeks. Follow-up was done finally after 2 weeks without medication. However, data of 90 patients were used for analysis. Hematological parameters, viz., hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular volume, packed cell volume, total iron-binding capacity, serum ferritin, and serum iron, were assessed at baseline, 42nd day, and at the end of the treatment period of 12 weeks (i.e., 84th day). Paired sample t-test was used to compare mean change from baseline with the 84th day. A p-value of <0.05 was considered significant.

Results
At the end of 12 weeks, compared with baseline, statistically significant increase was observed in mean serum iron level (p-value = 0.005). However, mean change from baseline to 84th day in hemoglobin level (p-value = 0.325) was not significant. A significant improvement in symptoms of anemia, such as weakness, fatigue, dizziness, and headache, was also seen. The treatment was found to be safe and effective in the patients with iron deficiency anemia as all the safety parameters were within the stipulated range. No adverse drug reaction or adverse events were reported during the trial period.

Conclusion
Punarnavadi Mandura and Dadimadi Ghrita administered together in the above-mentioned dose were found effective and safe in patients suffering from iron deficiency anemia.

How to cite this article
Sannd R, Meena HML, Das B, Yadav B, Dua P, Khanduri S, Rana R, Singhal R, Bhuyan GC, Ota S, Srikanth N, Padhi MM, Dhiman KS. Clinical Efficacy and Safety of Punarnavadi Mandura and Dadimadi Ghrita in the Management of Iron Deficiency Anemia: A Prospective Open-label Multicenter Study. J Res Ayurvedic Sci 2017;1(1):1-8.
Clinical Efficacy and Safety of Ashokarishta, Ashvagandha Churna and Pravala Pishti in the Management of Menopausal Syndrome: A Prospective Open-label Multicenter Study
Authors: Padhi MM , Tomar Rinku , Kumari Indira , Gangurde Vilas 
Published: August 2017

ABSTRACT

Introduction
The menopausal period comprises about one-third of average women's life. During this period, women are vulnerable to conditions caused by estrogen deficiency from short-term discomfort to long-term health problems.

Aim
To evaluate the clinical efficacy of Ashokarishta, Ashvagandha Churna and Pravala Pishti in the management of menopausal syndrome and to evaluate changes in the quality of life in women.

Materials and methods
This trial was a multicenter single-arm study conducted at three Institutes of Central Council for Research in Ayurvedic Sciences. One hundred fifteen women aged between 40 and 55 years with Kupperman menopausal index score ≥15, follicle-stimulating hormone ≥20 IU/L, and endometrial thickness ≤5 mm were included in the study. Three Ayurvedic classical formulations, viz., Ashokarishta, Ashvagandha Churna and Pravala Pishti, were administered for 12 weeks followed by subsequent 2 weeks without intervention follow-up. Outcome measures were changes in menopausal symptoms using menopause rating scale (MRS) and improvement in the quality of life using menopause-specific quality of life (MENQOL) questionnaire and they were assessed at the baseline, 84th day, and at the end of 2 weeks after the completion of intervention period. Paired sample t-test was used to compare mean change from baseline to 84th day. A p-value <0.05 was considered significant.

Results
The findings of the study reveal that the effect of therapy has shown statistically significant decrease in MRS total score (p-value <0.001). The mean MRS total score at the baseline was 22.43 and decreased to 5.29 after treatment at 84th day, and further reduced to 5.06 at the 14th week (follow-up period without trial interventions). The improvements of MENQOL in four domains, viz., vasomotor, psychosocial, sexual, and physical, at the end of 12th week and 14th week were also significant (p-value <0.001) in comparison with the baseline. Further, all the safety parameters like liver function tests and kidney function tests remained within the normal limits throughout the trial period and no adverse events or adverse drug reaction were reported, which confirm the clinical safety of the trial drugs.

Conclusion
Ashokarishta, Ashvagandha Churna and Pravala Pishti are found to be safe and effective in the management of menopausal syndrome.

How to cite this article
Tomar R, Sharma S, Kumari I, Gangurde V, Ota S, Dua P, Khanduri S, Yadav B, Rana R, Singhal R, Srikanth N, Padhi MM, Dhiman KS. Clinical Efficacy and Safety of Ashokarishta, Ashvagandha Churna and Pravala Pishti in the Management of Menopausal Syndrome: A Prospective Open-label Multicenter Study. J Res Ayurvedic Sci 2017;1(1):9-16.
An Open Label Efficacy Study of Amrita Guggulu and Pinda Taila in the Management of Hyperuricemia in Gout (Vatarakta) Patients
Authors: Sannd Rajesh , Padhi MM , Singh Harbans , Bhurke Laxman W , Kumari Krishna , Vedi SK , Singh Renu ,   Bharti 
Published: August 2017

ABSTRACT

Background
Vatarakta vis-à-vis gout is a common condition in both primary care and specialist practice. Gout is a systemic disease characterized by manifestations of chronic under­lying hyperuricemia, resulting in the deposition of monosodium urate crystals in various tissues. Gout is the most common of the crystal induced arthritis due to disturbed uric acid metabolism and precipitation of urate crystals in extracellular space of joints, periarticular tissue, bones, and other organs.

Aim and objective
To explore the therapeutic efficacy and safety of Amrita Guggulu and Pinda Taila in the management of hyperuricemia in gout (Vatarakta) patients.

Materials and methods
A total of 100 cases (25–65 years) of primary gouty arthritis fulfilling the diagnostic criteria as recommended by the American College of Rheumatology were selected for the present study from outpatient department of the Central Ayurveda Research Institute for Respiratory Disorders Patiala and Regional Ayurveda Research Institute for Urinary Disorders, Jammu, India, irrespective of their sex, religion, and socioeconomic status. Only those patients who presented themselves with at least 6 of 12 criteria of American College of Rheumatology (1977) were selected for the clinical trial. Amrita Guggulu was given 1000 mg twice daily orally and Pinda Taila was applied locally 10 mL twice daily for 84 days.

Results
The trial therapy was assessed based on the improvement in clinical features, Visual Analog Scale (VAS) score, Patient's Global Assessment Scale score, Physician's Global Assessment Scale Score, SF-36 Health Survey Score for quality of life (QOL), and biochemical parameters. Each patient was subjected to routine blood test, serum uric acid, liver function tests, and renal function tests before treatment, after 28 days of treatment, and after 84 days of treatment. The trial combination showed statistically significant improvement in the clinical manifestations, QOL as well as reduction in marker of hyperuricemia, i.e., serum uric acid; the mean serum uric acid at the baseline was 7.76 mg/dL, which was reduced to 6.50 mg/dL after the trial period of 84 days. There was also decrease in the level of VAS score, Patient's Global Assessment Scale score, and Physician's Global Assessment Scale score. There were no impairment in liver function test and renal function test, indicating the good safety profile of trial therapy.

Conclusion
Hence, Amrita Guggulu and Pinda Taila drug combination is an effective and safe remedy for gouty arthritis (Vatarakta) patients.

How to cite this article
Singh H, Sannd R, Bhurke LW, Kumari K, Singh R, Vedi SK, Kumar A, Bharti, Rana R, Singhal R, Srikanth N, Padhi MM, Dhiman KS. An Open Label Efficacy Study of Amrita Guggulu and Pinda Taila in the Management of Hyperuricemia in Gout (Vatarakta) Patients. J Res Ayurvedic Sci 2017;1(1):25-33.
A review on Lantana rhodesiensis Moldenke: traditional uses, phytochemical constituents and pharmacological activities
Authors: Jean BANGOU Mindiédiba , Nâg-Tiero MEDA Roland , Martin KIENDREBEOGO , Germaine NACOULMA Odile , Norma ALMARAZ-ABARCA 
Published: August 2017

<em>Lantana rhodesiensis</em> Moldenke an herbaceous, belonging to the Verbenaceae family is widely used in Africa folk medicine for the treatment of cancer, measles, malaria, smallpox, strength, coughs, fever, rheumatism, body pains, diabetes mellitus arrhythmia, parasitic diseases, arterial hypertension, old diarrhoeas. Many studies have been conducted on the chemical composition of the whole plant of <em>L. rhodesiensis</em> as well as biological activities. The aim of the present review was to give a detailed literature survey on its traditional uses, phytochemistry and therapeutical properties of <em>L. rhodesiensis</em>.
Curative effect of <em>Plumbago indica</em> root extract on thioacetamide induced hepatotoxicity in experimental rats
Authors: Binil Eldhose , Jayesh Kuriakose , Sankunni Latha Mukalel 
Published: August 2017

<p>The root parts of <em>Plumbago indica</em> is widely used in the Indian Ayurvedic traditional system. The study was designed to evaluate the hepato curative activity Plumbago<em> Indica</em> (PLBM) methanolic root extracts at different doses (100 and 200 mg/kg bw) against thioacetamide induced liver damage in albino wistar rats. Liver damage was induced by administration of Thioacetamide (100 mg/kg bw) and was assessed by evaluating the activity of liver-function marker enzymes, antioxidant enzymes and lipid peroxidation. The liver sections were evaluated for histopathological changes. PLBM significantly (<em>p </em>≤ 0.05) reversed the elevation of serum liver enzymes and hepatic levels of antioxidant markers. Histopathological findings also confirmed the curative effect of <em>Plumbago Indica</em> in a dose dependent manner. Thus this study scientifically rationale the use of <em>Plumbago indica </em> root as a promising drug against various liver disorders.</p>
Phytochemical screening and influence of extraction solvents on antioxidant and antimicrobial activities of Asparagus racemosus willd. Root
Authors: Tinrat Sirikhwan , Sila-asna Monnipha 
Published: August 2017

<p>The bioactive components present in the <em>Asparagus racemosus</em> root are known to be responsible for its medicinal properties. However, the solvent extraction for these bioactive components had effect on bioactive activities. The present study was aimed to compare the effect of using different extraction solvents to extract the active components, antioxidant and antimicrobial activities from <em>Asparagus racemosus</em> root. Aqueous (DW and NW) extracts showed the efficiency of <em>Asparagus racemosus</em> root as antioxidant agent and broad spectrum antibacterial agent against both Gram-positive and Gram-negative. 95% Ethanolic extract had the most potential in the Ferric Reducing Antioxidant Power (FRAP) of 14.400±0.001 mg AAE/100g FW. But aqueous (DW and NW) extracts showed the lowest IC<sub>50</sub> value of 4.716±0.002 - 4.757±0.001 mg/ml (IC<sub>50</sub> ascorbic acid of 3.422±0.001 mg/ml). Moreover, Natural distilled water extract had also the bactericidal effect on <em>P. aeruginasa</em> ATCC 27853 and <em>K. pneumoniae</em> and <em>E. faecalis</em> DMST 4736 at 3-6 h intervals after incubation. These biological activity may be due partly to the presence of various phytochemical compounds; phenolics, flavonoids saponins, steroids, terpenoids and cardiac glycosides. It also suggests that <em>Asparagus racemosus</em> root was a potential candidate in antioxidant and antimicrobial agents. It was useful in applications with modern medicine in the therapy or prevention of disease as well as the adoption in commercial various health products in the future. In addition to the ethanol and water were suitable solvent to extract the substance, natural distilled water was also the alternative solvent for bioactive compounds extraction. <strong></strong></p>