bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost‐effectiveness of indwelling pleural catheter compared with talc in malignant pleural effusion
Authors: Olfert Jordan A.P. , Penz Erika D. , Manns Braden J. , Mishra Eleanor K. , Davies Helen E. , Miller Robert F. , Luengo‐Fernandez Ramon , Gao Song , Rahman Najib M. 
Published: December 2016

ABSTRACT
Background and objectiveMalignant pleural effusion is associated with morbidity and mortality. A randomized controlled trial previously compared clinical outcomes and resource use with indwelling pleural catheter (IPC) and talc pleurodesis in this population. Using unpublished quality of life data, we estimate the cost‐effectiveness of IPC compared with talc pleurodesis.MethodsHealthcare utilization and costs were captured during the trial. Utility weights produced by the EuroQol Group five‐dimensional three‐level questionnaire and survival were used to determine quality‐adjusted life‐years (QALYs) gained. The incremental cost‐effectiveness ratio (ICER) was calculated over the 1‐year trial period. Sensitivity analysis used patient survival data and modelled additional nursing time required per week for catheter drainage.ResultsUtility scores, cost and QALYs gained did not differ significantly between groups. The ICER for IPC compared with talc was favorable at $US10 870 per QALY gained. IPC was less costly with a probability exceeding 95% of being cost‐effective when survival was <14 weeks, and was more costly when 2‐h nursing time per week was assumed for catheter drainage.Conclusion
IPC is cost‐effective when compared with talc, although substantial uncertainty exists around this estimate. IPC appears most cost‐effective in patients with limited survival. If significant nursing time is required for catheter drainage, IPC becomes less likely to be cost‐effective. Either therapy may be considered as a first‐line option in treating malignant pleural effusion in patients without history of prior pleurodesis, with consideration for patient survival, support and preferences.
Detecting Bias Arising from Delayed Recording of Time
Authors: De Stavola Bianca L. , Cox D. R. 
Published: December 2016

Summary
Sometimes in studies of the dependence of survival time on explanatory variables the natural time origin for defining entry into study cannot be observed and a delayed time origin is used instead. For example, diagnosis of disease may in some patients be made only at death. The effect of such delays is investigated both theoretically and in the context of the England and Wales National Cancer Register.
Statistical Inference of The Mechanisms Driving Collective Cell Movement
Authors: Ferguson Elaine A. , Matthiopoulos Jason , Insall Robert H. , Husmeier Dirk 
Published: December 2016

SummaryNumerous biological processes, many impacting on human health, rely on collective cell movement. We develop nine candidate models, based on advection–diffusion partial differential equations, to describe various alternative mechanisms that may drive cell movement. The parameters of these models were inferred from one-dimensional projections of laboratory observations of Dictyostelium discoideum cells by sampling from the posterior distribution using the delayed rejection adaptive Metropolis algorithm. The best model was selected by using the widely applicable information criterion. We conclude that cell movement in our study system was driven both by a self-generated gradient in an attractant that the cells could deplete locally, and by chemical interactions between the cells.
The Scandinavian Fantasy: The Sources of Intergenerational Mobility in Denmark and the US
Authors: Landersø Rasmus , Heckman James J. 
Published: December 2016

AbstractThis paper examines the sources of differences in social mobility between the US and Denmark. Measured by income mobility, Denmark is a more mobile society, but not when measured by educational mobility. There are pronounced non‐linearities in income and educational mobility in both countries. Greater Danish income mobility is largely a consequence of redistributional tax, transfer, and wage compression policies. While Danish social policies for children produce more favorable cognitive test scores for disadvantaged children, they do not translate into more favorable educational outcomes, partly because of disincentives to acquire education arising from the redistributional policies that increase income mobility.
Comparisons of the Interpersonal–Psychological Theory of Suicide Constructs Among Individuals Without Suicidality, Ideators, Planners, and Attempters
Authors: Forrest Lauren N. , Smith April R. 
Published: December 2016

The Interpersonal–Psychological Theory of Suicide (IPTS) proposes that combinations of thwarted belongingness, perceived burdensomeness, and acquired capability lead to suicide ideation, planning, and attempting. We compared individuals with and without suicidality on thwarted belongingness and perceived burdensomeness, and compared a combined group of planners and attempters to ideators on fearlessness about death (one component of acquired capability). Individuals with suicidality had higher thwarted belongingness and perceived burdensomeness than individuals without suicidality. Planners and attempters did not have higher fearlessness about death than ideators. These findings partially support IPTS hypotheses. Assessing thwarted belongingness and perceived burdensomeness may improve suicide risk determination.
Effect of live fences of Gliricidia sepium on CO2 fluxes in tropical livestock systems
Authors: Villanueva‐López G. , Casanova‐Lugo F. , Martínez‐Zurimendi P. , Parsons D. , Aguilar‐Solís L. A. 
Published: December 2016

AbstractLive fences have the potential to improve microclimatic conditions, moderate soil CO2 fluxes and function as carbon sinks. We quantified variation in soil CO2 fluxes from livestock silvopastoral systems under the canopies of live fences (LF), formed by Gliricidia sepium trees, or artificial fences (AF). We determined the responses of soil CO2 fluxes to environmental factors, including diurnal and seasonal variations in temperature and relative humidity in each fencing system. Measurements were made from April to June (dry season) and from July to September (rainy season), 2012. Fluxes were similar between the two livestock systems; LF emitted 1.00 μmol CO2/m2/s and AF 1.02 μmol CO2/m2/s. Soil temperatures at 5 cm depth were 3% warmer in AF than in LF, and relative humidity was 16% greater in LF than in AF. Seasonal variation in temperature greatly affected soil CO2 fluxes, which changed seasonally in parallel with temperature of the topsoil and relative humidity at 1 m height, peaking in late summer. Fluxes in LF and AF were greater in the rainy season (1.1 μmol CO2/m2/s, for both systems), when soil temperature was cooler and relative humidity was greatest, than during the dry season (0.9 μmol CO2/m2/s, for both systems). Soil fluxes were larger at night (00:00–06:00 h), when soil temperature was cooler and relative humidity greater, than during the morning (6:00–12:00 h), when soil temperature was warmer and relative humidity was less. The presence of G. sepium trees in LF did not influence soil CO2 fluxes.
A new genus and species of hypodermatine bot flies (Diptera: Oestridae)
Authors: PAPE THOMAS , PIWCZYŃSKI MARCIN , WYBORSKA DOMINIKA , AKBARZADEH KAMRAN , SZPILA KRZYSZTOF 
Published: December 2016

AbstractThe bot fly Gruninomyia mira Szpila & Pape, gen.n., sp.n. is described from Iran, North Khorasan, based on a single adult male and with no larval or host data. The monotypic genus shows a mixture of features otherwise found in either the rodent/lagomorph‐parasitizing oestromyine clade (Oestroderma + Oestromyia) or the artiodactyl‐parasitizing hypodermatine clade (Hypoderma + Pallasiomyia + Pavlovskiata + Przhevalskiana + Strobiloestrus) of subfamily Hypodermatinae. A morphology‐based phylogenetic analysis is marginally in favour of a position of Gruninomyia Szpila & Pape, gen.n. as sister taxon of (Oestroderma + Oestromyia). The COI barcode sequence is provided for the new species, and a phylogenetic analysis based on this marker for Oestridae retrieved from GenBank is in agreement with the conclusions based on morphological data.This published work has been registered in ZooBank: http://zoobank.org/urn:lsid:zoobank.org:pub:8F0CBE07‐4E74‐4186‐B690‐2C97D7ED7DA7.
The interrelated use of geological information and other types of geoinformation in local governments
Authors: Häggquist Elisabeth 
Published: December 2016

AbstractThere is a growing interest in the use of geoinformation in government decision‐making. Studies on the usability of geological information, which is one type of geoinformation, have however been scarce in the literature. A system built for an efficient organization may, therefore, not be catering to the needs of the individual user and understanding the perceived barriers to using geological information should be an important goal of geodata implementation. The objectives of this article are to: (1) investigate whether the analyses of user patterns are improved by considering an interrelated estimation with two types of geoinformation, and (2) explore whether there are gender differences in how peer advice affects the use of geoinformation. The data were collected in 2014 through a web survey, and the sample consisted of 390 women and 287 men working in Swedish municipalities. The results indicates a more accurate prediction pattern when a secondary geoinformation decision was included, thus suggesting that different types of geoinformation should be jointly analyzed. The officials tend to use both types of geoinformation, alluding to a demand for combined geoinformation products among the target population. Finally, there is evidence of women's decision to use geoinformation being affected by peer advice.
Brassinosteroid signaling converges with SUPPRESSOR OF PHYTOCHROME B4‐#3 to influence the expression of SMALL AUXIN UP RNA genes and hypocotyl growth
Authors: Favero David S. , Le Kimberly Ngan , Neff Michael M. 
Published: December 2016

SummaryInteractions between signaling pathways help guide plant development. In this study, we found that brassinosteroid (BR) signaling converges with SUPPRESSOR OF PHYTOCHROME B4‐#3 (SOB3) to influence both the transcription of genes involved in cell elongation and hypocotyl growth. Specifically, SOB3 mutant hypocotyl phenotypes, which are readily apparent when the seedlings are grown in dim white light, were attenuated by treatment with either brassinolide (BL) or the BR biosynthesis inhibitor brassinazole (BRZ). Hypocotyls of SOB3 mutant seedlings grown in white light with a higher fluence rate also exhibited altered sensitivities to BL, further suggesting a connection to BR signaling. However, the impact of BL treatment on SOB3 mutants grown in moderate‐intensity white light was reduced when polar auxin transport was inhibited. BL treatment enhanced transcript accumulation for all six members of the SMALL AUXIN UP RNA19 (SAUR19) subfamily, which promote cell expansion, are repressed by SOB3 and light, and are induced by auxin. Conversely, BRZ inhibited the expression of SAUR19 and its homologs. Expression of these SAURs was also enhanced in lines expressing a constitutively active form of the BR signaling component BZR1, further indicating that the transcription of SAUR19 subfamily members are influenced by this hormone signaling pathway. Taken together, these results indicate that SOB3 and BR signaling converge to influence the transcription of hypocotyl growth‐promoting SAUR19 subfamily members.
Overexpression of the triose phosphate translocator (TPT) complements the abnormal metabolism and development of plastidial glycolytic glyceraldehyde‐3‐phosphate dehydrogenase mutants
Authors: Flores‐Tornero María , Anoman Armand D. , Rosa‐Téllez Sara , Toujani Walid , Weber Andreas P.M. , Eisenhut Marion , Kurz Samantha , Alseekh Saleh , Fernie Alisdair R. , Muñoz‐Bertomeu Jesús , Ros Roc 
Published: December 2016

SummaryThe presence of two glycolytic pathways working in parallel in plastids and cytosol has complicated the understanding of this essential process in plant cells, especially the integration of the plastidial pathway into the metabolism of heterotrophic and autotrophic organs. It is assumed that this integration is achieved by transport systems, which exchange glycolytic intermediates across plastidial membranes. However, it is unknown whether plastidial and cytosolic pools of 3‐phosphoglycerate (3‐PGA) can equilibrate in non‐photosynthetic tissues. To resolve this question, we employed Arabidopsis mutants of the plastidial glycolytic isoforms of glyceraldehyde‐3‐phosphate dehydrogenase (GAPCp) that express the triose phosphate translocator (TPT) under the control of the 35S (35S:TPT) or the native GAPCp1 (GAPCp1:TPT) promoters. TPT expression under the control of both promoters complemented the vegetative developmental defects and metabolic disorders of the GAPCp double mutants (gapcp1gapcp2). However, as the 35S is poorly expressed in the tapetum, full vegetative and reproductive complementation of gapcp1gapcp2 was achieved only by transforming this mutant with the GAPCp1:TPT construct. Our results indicate that the main function of GAPCp is to supply 3‐PGA for anabolic pathways in plastids of heterotrophic cells and suggest that the plastidial glycolysis may contribute to fatty acid biosynthesis in seeds. They also suggest a 3‐PGA deficiency in the plastids of gapcp1gapcp2, and that 3‐PGA pools between cytosol and plastid do not equilibrate in heterotrophic cells.
Clinical characteristics of doxorubicin‐associated alopecia in 28 dogs
Authors: Falk Elizabeth F. , Lam Andrea T. H. , Barber Lisa G. , Ferrer Lluis 
Published: December 2016

BackgroundChemotherapy‐induced alopecia (CIA) is common in humans, but there are limited reports describing the clinical features of CIA in dogs.ObjectivesTo describe the epidemiological and clinical characteristics of doxorubicin‐associated alopecia (DAA) in canine patients at a teaching hospital from 2012 to 2014.AnimalsSignalment, diagnosis, treatment protocols and clinical examination findings were recorded in 150 dogs treated with doxorubicin from 2012 to 2014.MethodsMedical records were searched retrospectively for the keywords “alopecia” and “hypotrichosis.” Dogs were excluded if the causal link of hair loss was unclear.ResultsDoxorubicin‐associated alopecia was reported in 28 of 150 dogs (19%). Two parameters were statistically associated with the development of DAA: coat‐type and cumulative doxorubicin dose. Dogs with curly or wire‐haired coat‐type were significantly more likely to develop DAA than dogs with straight‐haired coat‐type [χ2 (1, N = 147) = 30, P < 0.0001]. After adjusting for sex, weight and doxorubicin dose, the odds of dogs with curly or wire‐haired coat‐type developing DAA were 22 times higher than those with straight‐haired coat‐type (P < 0.0001). Dogs that developed DAA received a significantly higher median cumulative doxorubicin dose (103.0 versus 84.5 mg/m2; P = 0.0039) than those that did not develop DAA.Conclusions and clinical importanceDogs treated with doxorubicin may be at risk for developing DAA. This risk increases as the cumulative dose of doxorubicin increases, and with a curly or wire‐haired coat‐type.
Aspirin treatment for chronic wounds: Potential beneficial and inhibitory effects
Authors: Darby Ian Andrew , Weller Carolina Dragica 
Published: December 2016

AbstractAspirin is a generally well‐tolerated drug that is now widely used in aged patients for its antithrombotic action. Aspirin works through several pathways to reduce inflammation, fever and to alter platelet activity. The scientific literature suggests that inhibition of the cyclooxygenase enzymes by aspirin or other nonsteroidal anti‐inflammatory drugs may be deleterious to normal wound repair processes and result in healing inhibition. However, novel effects of aspirin on other pathways that regulate inflammation and repair have been reported more recently. These pathways, including inhibition of inflammatory second messengers and transcription factor pathways and production of anti‐inflammatory, pro‐resolution factors (lipoxins), provide a possible explanation for beneficial effects of aspirin in chronic wound healing. There have been limited studies to date that provide good evidence to support aspirin use in chronic venous leg ulcers but this may change as we see results from randomized trials that are currently being undertaken. In this article, we look at possible effects that aspirin administration may have on venous leg ulcer healing and the expanding knowledge of potential beneficial effects of aspirin that operate via novel pathways. Though the literature suggests that aspirin treatment and cyclooxygenase inhibition may have deleterious effects in normal healing, it is possible that in chronic wounds that may be trapped in an inflammatory state that aspirin treatment may result in beneficial outcomes.
Effectiveness of Interactive Self‐Management Interventions in Individuals With Poorly Controlled Type 2 Diabetes: A Meta‐Analysis of Randomized Controlled Trials
Authors: Cheng Li , Sit Janet W. H. , Choi Kai‐chow , Chair Sek‐ying , Li Xiaomei , He Xiao‐le 
Published: December 2016

ABSTRACTAimsTo identify, assess,
and summarize available scientific evidence on the effectiveness of interactive self‐management interventions on glycemic control and patient‐centered outcomes in individuals with poorly controlled type 2 diabetes.MethodsMajor English and Chinese electronic databases including Medline, EMBASE, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, and WanFang Data were searched to identify randomized controlled trials that reported the effectiveness of interactive self‐management interventions in individuals with poorly controlled type 2 diabetes (glycated hemoglobin [HbA1c] ≥ 7.5% or 58 mmol/mol), from inception to June 2015. Data extraction and risk‐of‐bias assessment were performed by two reviewers independently. Meta‐analysis was performed using Review Manager 5.3.ResultsA total of 16 trials with 3,545 participants were included in the meta‐analysis. Interactive self‐management interventions could have a beneficial effect in individuals with poorly controlled type 2 diabetes in reducing HbA1c (mean difference: −0.43%, 95% CI: −0.67% to −0.18%), improving diabetes knowledge (standardized mean difference [SMD]: 0.30, 95% CI: 0.03 to 0.58), enhancing self‐efficacy (SMD: 0.29, 95% CI: 0.14 to 0.44), and reducing diabetes‐related distress (SMD: −0.21, 95% CI: −0.39 to −0.04). Self‐management interventions supported with theory and structured curriculum showed desirable results in glycemic control. The behavioral change techniques, including providing feedback on performance, problem‐solving, and action planning, were associated with a significant reduction in HbA1c.Linking Evidence to ActionIndividuals with poorly controlled type 2 diabetes could benefit from interactive self‐management interventions. Interventions targeting patients with poorly controlled diabetes, those who are at the greatest risk of developing complications, should be prioritized. Our findings indicate that providing feedback on performance, problem‐solving, and action planning are promising behavioral change techniques specifically for individuals with poor glycemic control.
Elevated skin and core temperatures both contribute to reductions in tolerance to a simulated haemorrhagic challenge
Authors: Pearson James , Lucas Rebekah A. I. , Schlader Zachary J. , Gagnon Daniel , Crandall Craig G. 
Published: December 2016

New Findings
What is the central question of this study?
Combined increases in skin and core temperatures reduce tolerance to a simulated haemorrhagic challenge. The aim of this study was to examine the separate and combined influences of increased skin and core temperatures upon tolerance to a simulated haemorrhagic challenge.

What is the main finding and its importance?
Skin and core temperatures increase during many occupational settings, including military procedures, in hot environments. The study findings demonstrate that both increased skin temperature and increased core temperature can impair tolerance to a simulated haemorrhagic challenge; therefore, a soldier's tolerance to haemorrhagic injury is likely to be impaired during any military activity that results in increased skin and/or core temperatures.

Tolerance to a simulated haemorrhagic insult, such as lower‐body negative pressure (LBNP), is profoundly reduced when accompanied by whole‐body heat stress. The aim of this study was to investigate the separate and combined influence of elevated skin (Tskin) and core temperatures (Tcore) on LBNP tolerance. We hypothesized that elevations in Tskin as well as Tcore would both contribute to reductions in LBNP tolerance and that the reduction in LBNP tolerance would be greatest when both Tskin and Tcore were elevated. Nine participants underwent progressive LBNP to presyncope on four occasions, as follows: (i) control, with neutral Tskin (34.3 ± 0.5°C) and Tcore (36.8 ± 0.2°C); (ii) primarily skin hyperthermia, with high Tskin (37.6 ± 0.2°C) and neutral Tcore (37.1 ± 0.2°C); (iii) primarily core hyperthermia, with neutral Tskin (35.0 ± 0.5°C) and high Tcore (38.3 ± 0.2°C); and (iv) combined skin and core hyperthermia, with high Tskin (38.8 ± 0.6°C) and high Tcore (38.1 ± 0.2°C). The LBNP tolerance was quantified via the cumulative stress index (in millimetres of mercury × minutes). The LBNP tolerance was reduced during the skin hyperthermia (569 ± 151 mmHg min) and core hyperthermia trials (563 ± 194 mmHg min) relative to control conditions (1010 ± 246 mmHg min; both P < 0.05). However, LBNP tolerance did not differ between skin hyperthermia and core hyperthermia trials (P = 0.92). The lowest LBNP tolerance was observed during combined skin and core hyperthermia (257 ± 106 mmHg min; P < 0.05 relative to all other trials). These data indicate that elevated skin temperature, as well as elevated core temperature, can both contribute to reductions in LBNP tolerance in heat‐stressed individuals. However, heat stress‐induced reductions in LBNP tolerance are greatest in conditions when both skin and core temperatures are elevated.