bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimalisasi Intervensi Terapi Musik Klasik Terhadap Penurunan Tingkat Halusinasi Pendengaran Pada Pasien Gangguan Jiwa Di Rsjd Dr.Rm.Soedjarwadi Klaten Provinsi Jawa Tengah
Authors: Nadia Sulisti Azizah  , Sitti Rahma Soleman  , Wahyu Reknoningsih  
Published: September 2024

Background: Mental disorders are the condition of a person who has experienced disturbances in psychiatric functions, such as thought processes, emotions, willpower and psychomotor behavior. This type of music therapy is used for a variety of conditions including psychiatric disorders, medical problems, physical disability conditions, sensory disorders, developmental disabilities, and aging issues, to improve study concentration, support physical exercise, and stress and anxiety. Objective: To determine the results of the implementation of classical music therapy on the reduction of auditory hallucinations in patients with mental disorders at Dr. RM Hospital. Soedjarwadi Klaten. Methods: In this study, using the pre-test and post-test case study method conducted on two respondents, hallucination measurements were carried out with AHRS (Auditory Hallucinations Rating Scale), then classical music therapy was given for three days with a frequency of 1 time a day within 10-15 minutes. Results: The results obtained from the description and discussion above show that after 3 days of intervention on both respondents Mrs. M and Mrs. S respectively, namely 36:35, there was a significant decrease in auditory hallucination scores. Conclusions: There was a decrease in symptoms and hallucinations in both respondents after being given the classical music intervention with" a ratio of the AHRS scale of 22:20.
Integrasi Ilmu Pengetahuan Dalam Perspektif Filsafat Pendidikan Islam
Authors: Azizah Hanum OK  , Nurul Amirah  , Dicky Armanda  
Published: September 2024

This journal investigates the concept of knowledge integration in the context of Islamic education, viewed from the perspective of Islamic educational philosophy. Using philosophical analysis, this paper explores how science can be integrated holistically in the context of Islamic education. The approach applied is a qualitative method, focusing on data collection and analysis without the need for statistical calculations. This journal relies on library literature without involving direct observation or interviews, by utilizing various sources of information such as books, academic journals, magazines, newspapers and related literature. Based on Islamic educational philosophy, the main aim of this paper is to provide a deeper understanding of how to integrate science in the context of Islamic education in accordance with the views of Islamic educational philosophy.
Pengaruh Personal Selling, Respon Nasabah dan Minat Nasabah Terhadap Keputusan Nasabah dalam Mengaktifkan Aplikasi BRImo Mobile Banking
Authors: Saryadi Saryadi  , Indra Hastuti  , Liss Dyah Dewi Arini  
Published: September 2024

This study aims to determine the influence of personal selling, customer response, and customer interest on customer decisions in activating the BRImo application. Research is a type of quantitative research. A sample of 100 respondents using GForm from a total population of 3100. by accidental random sampling. The method uses multiple linear regression with statistical tests and classical assumptions. Classic assumptions are not a problem. The results showed that customer responses and customer interest were significantly positive in influencing customer decisions in activating the BRImo application, while personal selling had a positive effect was not significant. The F test shows that the simultaneous influence of personal selling, customer response and customer interest in customer decisions is significant, which is 70.298 with a significant value of 0.00< 0.05. The coefficient of determination is 0.687. This shows that the customer's decision can be explained by 68.7% by personal selling, customer response, and customer interest. The remaining 0.313 or 3.13% is explained by other variables outside the model, such as customer knowledge and education. The most dominant variable in influencing customer decisions is the customer response, which is shown to be a regression coefficient of 0.354 with a t-count of 4.153.
Synthesis and anticancer activity of new heterocyclic derived from diaryl β-lactam supported by molecular docking and toxicity LD50
Authors: Mohammed Fadhil Hassan  , Duaa Qassim kamil  , Thaer khazaal makki  , Muqdad Irhaeem Kadhim  , Hussein Ali Kadhim Kyhoiesh  
Published: September 2024

A novel compound called 3-chloro-4-(4-(dimethylamino)phenyl)-1-(6-methoxybenzo[d]thiazol-2-yl)azetidin-2-one (3-CDBA), derived from beta-lactams, was investigated for its effects on human leukemia (HL-60) cells, pancreatic cancer (TCP-1026) cells, and healthy cells (WRL68) for comparison. The compound showed an inhibitory concentration (IC50) of 91.55 µg/ml on the leukemia cells, 141.3 µg/ml on the pancreatic cancer cells, and 353.8 µg/ml on the healthy cells. This indicates that the compound selectively kills cancer cells while having minimal effect on healthy cells, as higher concentrations are required to kill half of the healthy cells. These findings suggest that the compound has the potential to inhibit the growth of cancer cells. In comparison to conventional antioxidants like ascorbic acid (vitamin C), the beta-lactam derivative (3-CDBA) exhibited a higher percentage of inhibition at the highest concentration, with a value of 72.95% and an IC50 of 42.67 µg/ml. Furthermore, the compound's effects were studied on two types of pathogenic bacteria, specifically Staphylococcus aureus (positive) and Escherichia coli (negative), as well as various Penicillium species. The compound showed the greatest inhibitory effect at a concentration of 1000 µg/ml. In a theoretical examination, molecular docking was employed to design and synthesize a drug using the beta-lactam derivative and a target associated with cancer cells from a protein database. The compound demonstrated a strong and close interaction with amino acids and different sites within the active pocket, resulting in a higher binding energy. This indicates that the compound has the potential to inhibit the growth of cancer cells by disrupting their metabolic processes. To determine the lethal dose (LD50), the beta-lactam derivative (3-CDBA) was administered to half of the animals in the study.
The Accuracy Of Ultrasonography And CT Scans In Diagnosing Liver Tumours
Authors: Salima Baqir Alsaadi  , Saad Abdul Kareem Mohammed  , Ali I. Omran Al-Saadawi  
Published: September 2024

Both benign and malignant liver tumours may occur. Multiple nodules or a single mass might be diffusely invasive. Our research diagnosed patients using CT scans and ultrasounds. We compared these strategies to determine which is better. A precise biopsy was performed on each tissue liver tumour to confirm the diagnosis of liver tumour. A 40 liver tumour patients were participated in this study included 24 men and 16 women. The average patient age was 52. The biopsy results were compared to CT and ultrasonography data for each subject. Ultrasonography resulted in 23 (57.5%) patients with malignant tumours and 9 (22.5) benign tumours, of which 8 (20%) were healthy. On the other hand, the CT scan results showed that 23 individuals (57.5%) had malignant tumours, and 17 (42.5%) had benign ones. These data suggest that CT scans are 100% more efficient than ultrasonography in identifying liver tumours.
Knowledge, Attitude and Practice Regarding Breast Cancer and Breast Self-Examination Among A Sample Of Women In Al-Diwaniyah City
Authors: Sarah Abdul Kareem Abdul Jabar  , Hassan Raji Jallab  
Published: September 2024

Background: breast cancer is the most common cancer among women, also it is the leading cause of cancer-related deaths in low-resource countries. So, every woman should know what it looks like, be aware of any changes, and know what to do if they are discovered. Meanwhile, early diagnosis and management are fundamental steps toward increasing survival and improving the quality of life Aims: The purpose of this study is to determine the knowledge, attitudes and practices of women in Al_Diwaniaya city regarding breast self-examination, and to explore their level of knowledge about breast cancer focusing on some risk factors.Method: Cross- sectional _ study was conducted among 350 women aged more than 18 years who attended breast screening department in Al- Diwaniyah teaching hospital during the period of study using face-to-face interviews questionnaire. Results: The total sample included in this study was 350 females, regarding the score of knowledge, the results showed near half of participants having moderate knowledge (49.1%), On the other hand, the attitude of study people was more interesting by enrolling questions. Concerning the attitude score, the findings indicated that 64% of the subjects had a moderate attitude. In terms of practice score, the findings revealed that 57% of participants had poor practice and only 6% had good practice. The study discovered that the age groups under 40 had better knowledge, attitudes, and practices than the age groups over 40, with a positive correlation also (p<0.001) in high education group.Conclusions: The results showed most of participants having moderate to good knowledge (78%) moderate attitude but poor practice of breast self-examination. the gap in knowledge in fields of breast self-examination emphasizes on the need to raise awareness among women about the correct method and timing of it.
Risk Factors That Lead To Poor Glycemic Control In Type 2 Diabetic Patients Attending Al Diwaniya Diabetes Mellitus Center In 2023
Authors: Lara Noori Hamza  , Hassan Raji  Jallab  
Published: September 2024

Background: Diabetes mellitus (DM) is the most common metabolic disorder worldwide. DM is the most common chronic illness in adults. It is estimated that 300 million people will have DM by 2025, and it will reach approximately 439 million and the prevalence is estimated to be 7.7% by 2030. The decrease of blood glucose levels in patients with DM decreases the mortality and morbidity rates significantly.Objective: To identify the potential risk factors of poor glycemic control among patients having type2 Diabetes mellitus in Al-diwaniya city. Methods: A total of 340 patients were included in the study. This was cross sectional study conducted in the Diabetes Center at Al-diwaniya city, Iraq, from period of 1st of February to the 1st September2023. Based on the cutoff point of Glycosylated hemoglobin of 7, the poor control were the patients with (Glycosylated hemoglobin is ≥ 7) and the good control were the diabetic patient with Glycosylated hemoglobin is <7. A questionnaire developed to gather the demographic, lipid profile, disease characteristics and lifestyles behaviors and filled by the researcher through direct interview. Results: The total number of poor controls was 221 and the good control was 119 patients. There was no significant difference between the two groups regarding sex, age, marital status and occupation. A significant association was observed between the control status and high education level (p=0.001) dyslipidemia (p=0.001), cholesterol level (P=0.002), high TG level (p<0.001), and LDL level (p=0.025). Smoking, Body Mass Index and HDL level were not significant factors (p>0.005). All disease characteristics including the duration, family history of DM, FBS, type of medication were significant factors (p<0.001). Lifestyles behaviors including self-monitoring, healthy diet, physical activity, and adherence were significant factors (p<0.001). Conclusion: The most important potential risk factors for poor control diabetes were dyslipidemia, poor adherence and longer duration of diabetes. Enhancement of education of the patients and their healthcare providers on these factors are great benefit in glycemic control.
Pemberdayaan Masyarakat Melalui Pengembangan Desa Wisata Pantai di Desa Bondalem, Kecamatan Tejakula, Kabupaten Buleleng
Authors: Prastha Gede Sughi Adnyana Ousadhi 
Published: September 2024

The purpose of this study is to develop village tourism in empowering coastal community resources in Bondalem Village, Tejakula District, Buleleng Regency. The research method used in this study is a qualitative approach. The data types consist of both qualitative and quantitative data. The data sources consist of primary and secondary data. The main informants in this study are the tourism awareness group. Additional informants are the people of Bondalem village who provide information related to other matters not obtained from key informants and main informants. Data collection techniques include observation, interviews, and documentation. Data analysis techniques are divided into four, namely data collection, data reduction, data presentation, and conclusion drawing. The research results indicate the need for improvement in empowering natural resources and community resources, focusing on community empowerment in Bondalem Village. The challenges arising from the management of Bondalem ecodive are the lack of qualified human resources, as evidenced by the lack of individuals with diving certifications.
ABSTRAK
Tujuan penelitian ini mengembangkan desa wisata dalam pemberdayaan sumberdaya masyarakat pesisir di Desa Bondalem , Kecamatan Tejakula, Kabupaten Buleleng. Metode penelitian yang digunakan dalam penelitian ini adalah pendekatan kualitatif. Jenis data terdiri dari kualitatif dan kuantitatif. Sumber data terdiri dari data primer dan sekunder. Para informan utama dalam penelitian ini adalah kelompok sadar wisata. para informan tambahan yakni masyarakat desa Bondalem yang memberikan informasi terkait hal-hal lain yang tidak di dapatkan dari informan kunci dan informan utama. Teknik pengumpulan data dengan observasi, wawancara, dokumentasi Teknik analisis data dibagi menjadi empat, yakni pengumpulan data, reduksi data,penyajian data dan penarikan kesimpulan.Hasil penelitian menunjukkan bahwa perlu penyempurnaan dalam memberdayakan sumber daya alam dan sumber daya masyarakat, yang dalam hal ini berfokus pada pemberdayaan masyarakat di Desa Bondalem. Kendala yang muncul dari pengelolaan Bondalem ecodive adalah sumber daya manusia yang kurang memumpuni bisa dilihat dari kurangnya individu yang bersertifikat menyelam (diving).
Kata Kunci: Pemberdayaan Masyarakat, Pengembangan Desa Wisata.
PENERAPAN SISTEM PENGENDALIAN MANAJEMEN PADA SHINEWING INDONESIA
Authors: Yani Susetyo  , Chaterine Febby Larasati  
Published: September 2024

Shinewing Indonesia menerapkan sistem kontrol manajemen. Penelitian ini bertujuan untuk untuk membandingkan penerapan sistem pengendalian manajemen secara konseptual dan empiris di Shinewing Indonesia, bukan untuk menjelaskan keefektifannya. Penelitian ini membandingkan teori yang dipelajari dengan kegiatan praktik aktual yang berkaitan dengan penerapan sistem pengendalian manajemen di Shinewing Indonesia. Penelitian ini menggunakan metodologi kualitatif. Observasi dan wawancara digunakan untuk mengumpulkan data untuk penyelidikan ini. Temuan penelitian ini menunjukkan bahwa sistem pengendalian manajemen yang diterapkan di Shinewing Indonesia sangat berhasil dalam meningkatkan kinerja bisnis.
TINJAUAN HUKUM ISLAM TERHADAP SISTEM KEDUK PENGELOLAAN LAHAN PERTANIAN
Authors: Zainur Ridho  , Naylal Fithri  , Fasihul Lisan  
Published: September 2024

Tujuan dari penelitian ini yaitu bagaimana tinjauan hukum Islam tentang sistem pelaksanaan terhadap praktek kerjasama sietem Keduk dengan akad muzara’ah. dan tidak sedikit dari lahan di Desa Bulu dekat dengan aliran sungai, sehingga Desa ini disebut dengan Desa agraris. Kebanyakan pemilik sawah tidak mengelola sawahnya Penelitian dilakukan dengan melakukan wawancara (interview), dan obeservesi. Dilihat dari segi sumber data, bahan tambahan yang berasal dari sumber tertulis yaitu majalah ilmiah. Dari penelitian yang telah dilakukan dapat diketahui bahwa Pelaksanaan perjanjian bagi hasil antara pemilik sawah dan penggarap sawah masyarakat Desa Bulu, menggunakan sistem yang disebut dengan sistem Keduk. Sistem bagi hasi tersebut relatif jauh berbeda karena 20% untuk penggarap dan 80% untuk pemilik sawah, namun Apabila ditinjauan pada Hukum Islam kerjasama tersebut sah menurut hukum selama syarat dan rukunnya masih terpenuhi serta mempunyai kekuatan hukum yang tetap, karena tidak bertentangan dengan al-Qur’an dan Sunnah Rasulullah saw.
PENGARUH PELATIHAN DAN PENDAMPINGAN TERHADAP PENINGKATAN PENDAPATAN MUSTAHIQ BUNDA YATIM LAZ RUMAH AMAL ISTIQOMAH SIDOARJO
Authors: Reza Robby Reza Zulfikri 
Published: September 2024

Penelitian yang berjudul “Pengaruh Pelatihan dan Pendampingan terhadap Peningkatan Pendapatan Mustahiq Bunda Yatim LAZ Rumah Amal Istiqomah Sidoarjo” ini menggunakan penelitian kuantitatif yang bertujuan untuk mengetahui apakah pelatihan dan pendampingan berpengaruh secara signifikan terhadap peningkatan pendapatan mustahiq Bunda Yatim LAZ Rumah Amal Istiqomah Sidoarjo dan seberapa besar pengaruh pelatihan dan pendampingan terhadap peningkatan pendapatan mustahiq Bunda Yatim LAZ Rumah Amal Istiqomah Sidoarjo.
Penelitian ini menggunakan metode deskriptif kuantitatif. Jumlah sampel dalam penelitian ini sebanyak 30 responden. Adapun responden dalam penelitian ini adalah anggota Bunda Yatim LAZ Rumah Amal Istiqomah Sidoarjo. Teknik pengumpulan data dengan memberi kuesioner pada responden, wawancara dan dokumentasi. Dalam membuktikan dan menganalisis hal tersebut, maka digunakan uji validitas dan reliabilitas, uji asumsi klasik, uji regresi linier berganda serta uji f (simultan) dan uji t (parsial).
Hasil pengujian menunjukkan bahwa pelatihan dan pendampingan yang diberikan oleh LAZ Rumah Amal Istiqomah kepada anggota Bunda Yatim yang berupa pelatihan wirausaha dengan membuat aneka olahan bandeng dan pembuatan kue kering berpengaruh secara siginifikan terhadap peningkatan pendapatan mustahiq Bunda Yatim LAZ Rumah Amal Istiqomah Sidoarjo. Hasil pengujian tersebut diperoleh dari uji F yaitu Fhitung ≥Ftabel (13.533 ≥3.35) dan uji T yang menunjukkan nilai signifikansi pada variabel pelatihan (X1) 0.049 dan pada variabel pendampingan (X2) 0.025 atau ≤ 0.05, sehingga pelatihan (X1) dan pendampingan (X2) berpengaruh secara simultan maupun parsial terhadap peningkatan pendapatan (Y) mustahiq Bunda Yatim LAZ Rumah Amal Istiqomah Sidoarjo dengan besar R square 0,500 atau 50%.
Saran yang dapat penulis berikan bagi LAZ Rumah Amal Istiqomah Sidoarjo, yaitu agar lebih fokus dan konsisten dalam hal upaya pelatihan dan pendampingan yang diberikan kepada para mustahiq pada setiap program penyaluran zakat yang ada.

Kata Kunci: Pelatihan; Pendampingan dan Peningkatan Pendapatan.
Seasonal mouse cadaver microbial study: rupture time and postmortem interval estimation model construction
Authors: Zhao Xingchun , Yang Fengqin , Yang Fan , Nie Hao , Hu Sheng , Gui Peng , Guo Yadong , Zhang Changquan 
Published: September 2024

The estimation of postmortem interval (PMI) has long been a focal point in the field of forensic science. Following the death of an organism, microorganisms exhibit a clock-like proliferation pattern during the course of cadaver decomposition, forming the foundation for utilizing microbiology in PMI estimation. The establishment of PMI estimation models based on datasets from different seasons is of great practical significance. In this experiment, we conducted microbiota sequencing and analysis on gravesoil and mouse intestinal contents collected during both the winter and summer seasons and constructed a PMI estimation model using the Random Forest algorithm. The results showed that the MAE of the gut microbiota model in summer was 0.47 ± 0.26 d, R2 = 0.991, and the MAE of the gravesoil model in winter was 1.04 ± 0.22 d, R2 = 0.998. We propose that, in practical applications, it is advantageous to selectively build PMI estimation models based on seasonal variations. Additionally, through a combination of morphological observations, gravesoil microbiota sequencing results, and soil physicochemical data, we identified the time of cadaveric rupture for mouse cadavers, occurring at around days 24–27 in winter and days 6–9 in summer. This study not only confirms previous research findings but also introduces novel insights, contributing to the foundational knowledge necessary to advance the utilization of microbiota for PMI estimation.
Identifying transgene insertions in Caenorhabditis elegans genomes with Oxford Nanopore sequencing
Authors: Adams Paula E. , Thies Jennifer L. , Sutton John M. , Millwood Joshua D. , Caldwell Guy A. , Caldwell Kim A. , Fierst Janna L. 
Published: September 2024

Genetically modified organisms are commonly used in disease research and agriculture but the precise genomic alterations underlying transgenic mutations are often unknown. The position and characteristics of transgenes, including the number of independent insertions, influences the expression of both transgenic and wild-type sequences. We used long-read, Oxford Nanopore Technologies (ONT) to sequence and assemble two transgenic strains of Caenorhabditis elegans commonly used in the research of neurodegenerative diseases: BY250 (pPdat-1::GFP) and UA44 (GFP and human α-synuclein), a model for Parkinson’s research. After scaffolding to the reference, the final assembled sequences were ∼102 Mb with N50s of 17.9 Mb and 18.0 Mb, respectively, and L90s of six contiguous sequences, representing chromosome-level assemblies. Each of the assembled sequences contained more than 99.2% of the Nematoda BUSCO genes found in the C. elegans reference and 99.5% of the annotated C. elegans reference protein-coding genes. We identified the locations of the transgene insertions and confirmed that all transgene sequences were inserted in intergenic regions, leaving the organismal gene content intact. The transgenic C. elegans genomes presented here will be a valuable resource for Parkinson’s research as well as other neurodegenerative diseases. Our work demonstrates that long-read sequencing is a fast, cost-effective way to assemble genome sequences and characterize mutant lines and strains.