bluuebunny/crossref_metadata_2025_split huggingface dataset:
CILIOCHOROIDAL EFFUSION AND ACUTE MACULAR NEURORETINOPATHY ASSOCIATED WITH CERVICAL TRACTION THERAPY
Authors: Dedania Vaidehi S. , Ghodasra Devon H. , Kay Christine N. , Roseman Robert , Johnson Mark W. 
Published: September 2016

Purpose:
To report an unusual case of ciliochoroidal effusion and presumed acute macular neuroretinopathy associated with cervical traction therapy for the treatment of cervical spinal stenosis.

Methods:
Case report.

Results:
A 75-year-old man reported sudden onset of a wedge-shaped paracentral scotoma in the right eye. Fundus examination showed a ciliochoroidal effusion in the right eye. Optical coherence tomography revealed intraretinal fluid in both eyes without leakage on fluorescein angiography. B-scan ultrasonography and anterior segment ultrasound biomicroscopy of the right eye showed peripheral ciliochoroidal effusion. He had recently started intensive cervical traction therapy for the treatment of cervical spinal stenosis. There was spontaneous resolution of the choroidal effusion and intraretinal fluid after stopping cervical traction treatments. Optical coherence tomography imaging after resolution of the intraretinal fluid revealed thinning of the outer nuclear layer and attenuation of the ellipsoid and interdigitation zones corresponding to a persistent paracentral scotoma, consistent with acute macular neuroretinopathy.

Conclusion:
This is the first report of adverse ocular effects of cervical traction. We postulate that venous and arterial compromise during cervical traction therapy resulted in both ciliochoroidal effusion and a watershed infarct in the outer retina.
Legionnaires Disease With Focal Neurologic Deficits and a Reversible Lesion in the Splenium of the Corpus Callosum
Authors: Raybould Jillian E. , Conroy Megan E. , Timpone Joseph G. , Kumar Princy N. 
Published: September 2016

Abstract
Patients with Legionnaires pneumonia frequently present with neurologic abnormalities but normal neuroimaging findings. We present a case of a healthy 52-year-old man presenting with severe Legionella pneumonia and a unique constellation of focal neurologic deficits including bowel and bladder incontinence, hemiparesis, and ataxia with progression to somnolence. A transient lesion was identified at the splenium of the corpus callosum on magnetic resonance imaging. His recovery was marked by prolonged limb and oral apraxia, but the patient improved with an early combination antibiotic treatment and the late use of corticosteroids. To our knowledge, this is the ninth case reported in the English literature of a patient presenting with Legionnaires disease with neurologic deficits and a reversible lesion at the splenium of the corpus callosum. We present a review of the literature including previous cases, with a focus on neurologic examination, neuroimaging findings, combination antibiotic therapy, and the use of corticosteroids.
Implementing Effective Policy in a National Mental Health Reengagement Program for Veterans
Authors: Smith Shawna N. , Lai Zongshan , Almirall Daniel , Goodrich David E. , Abraham Kristen M. , Nord Kristina M. , Kilbourne Amy M. 
Published: September 2016

Abstract
Policy is a powerful motivator of clinical change, but implementation success can depend on organizational characteristics. This article used validated measures of organizational resources, culture, and climate to predict uptake of a nationwide Veteran's Health Administration (VA) policy aimed at implementing Re-Engage, a brief care management program that reestablishes contact with veterans with serious mental illness lost to care. Patient care databases were used to identify 2738 veterans lost to care. Local recovery coordinators (LRCs) were to update disposition for 2738 veterans at 158 VA facilities and, as appropriate, facilitate a return to care. Multivariable regression was used to assess organizational culture and climate as predictors of early policy compliance (via LRC presence) and uptake at 6 months. Higher composite climate and culture scores were associated with higher odds of having a designated LRC but were not predictive of higher uptake. Sites with LRCs had significantly higher rates of updated documentation than sites without LRCs.
Fundus Autofluorescence in Age-related Macular Degeneration
Authors: Ly Angelica , Nivison-Smith Lisa , Assaad Nagi , Kalloniatis Michael 
Published: September 2016

ABSTRACT

Fundus autofluorescence (FAF) provides detailed insight into the health of the retinal pigment epithelium (RPE). This is highly valuable in age-related macular degeneration (AMD) as RPE damage is a hallmark of the disease. The purpose of this paper is to critically appraise current clinical descriptions regarding the appearance of AMD using FAF and to integrate these findings into a chair-side reference. A wide variety of FAF patterns have been described in AMD, which is consistent with the clinical heterogeneity of the disease. In particular, FAF imaging in early to intermediate AMD has the capacity to reveal RPE alterations in areas that appear normal on funduscopy, which aids in the stratification of cases and may have visually significant prognostic implications. It can assist in differential diagnoses and also represents a reliable, sensitive method for distinguishing reticular pseudodrusen. FAF is especially valuable in the detection, evaluation, and monitoring of geographic atrophy and has been used as an endpoint in clinical trials. In neovascular AMD, FAF reveals distinct patterns of classic choroidal neovascularization noninvasively and may be especially useful for determining which eyes are likely to benefit from therapeutic intervention. FAF represents a rapid, effective, noninvasive imaging method that has been underutilized, and incorporation into the routine assessment of AMD cases should be considered. However, the practicing clinician should also be aware of the limitations of the modality, such as in the detection of foveal involvement and in the distinction of phenotypes (hypo-autofluorescent drusen from small areas of geographic atrophy).
Evaluation of the SVOne Handheld Autorefractor in a Pediatric Population
Authors: Rosenfield Mark , Ciuffreda Kenneth J. 
Published: September 2016

ABSTRACT

Purpose
The SVOne is a portable, Hartmann-Shack wavefront aberrometer, which can be attached to a smartphone to determine the refractive error of the eye objectively. Previous results have shown the device to provide measurements equivalent to those of standard clinical techniques in young, healthy adults. The aim of the present study was to compare the findings of the SVOne with retinoscopy, subjective refraction, and two commercially available autorefractors (Retinomax-3 and WAM-5500) in a pediatric population.

Method
The refractive error of the right eye was assessed both without and with cycloplegia in 40 visually normal children between 5 and 17 years of age (mean age = 11.3 years) using the five techniques described above. Further, to assess repeatability of the instruments, the entire procedure was repeated in a subgroup of five subjects. All data were analyzed in terms of power vectors (M, J0, and J45).

Results
No significant difference was observed between the mean values of M (spherical equivalent) for the different techniques. Retinoscopy showed the best agreement with subjective refraction, both without and with cycloplegia, followed by the open-field WAM-5500. The most repeatable procedures, when measured without and with cycloplegia, were the WAM-5500 and retinoscopy, respectively. Measurements with the SVOne showed a decline in repeatability under cycloplegia.

Conclusions
The results indicate that the SVOne provides measurements of refractive error in a normal, pediatric population that are not significantly different from other subjective and objective procedures. Accurate alignment along the visual axis, especially when measuring through a dilated pupil, is critical. This instrument is valuable for vision screenings, for examinations taking place outside the clinical office, and a starting point for the refractive assessment.
Identifying the Species Threat Hotspots from Global Supply Chains
Authors: Moran Daniel , Kanemoto Keiichiro 
Published: September 2016

Summary SentenceSpatially explicit footprints make it possible to locate biodiversity hotspots linked to global supply chains.Identifying species threat hotspots has been a successful approach for setting conservation priorities. One major challenge in conservation is that in many hotspots export industries continue to drive overexploitation. Conservation measures must consider not just the point of impact, but also the consumer demand that ultimately drives resource use. To understand which species threat hotspots are driven by which consumers, we have developed a new approach to link a set of biodiversity footprint accounts to the hotspots of threatened species on the IUCN Red List. The result is a map connecting global supply chains to impact locations. Connecting consumption to spatially explicit hotspots driven by production has not been done before on a global scale. Locating biodiversity threat hotspots driven by consumption of goods and services can help connect conservationists, consumers, companies, and governments in order to better target conservation actions.
Learning of speech categories in humans and Zebra Finches
Authors: Botskaris D. , Kriengwatana B. , ten Cate C. 
Published: September 2016

AbstractThe survival of organisms depends highly on their ability to adjust their behavior according to proper categorizations of various events. More than one strategy can be used in categorization. One is the Rule-Based (RB) strategy and the other is Information-Integration (II) strategy. In this research we analyzed the differences between avian and human cognition. Twelve Greek listeners and four Zebra finches were tested in speech category learning tasks. In particular, both humans and Zebra finches had to categorize between Dutch vowels that differ on duration, frequency or both depending on the condition. Feedback was given for correct and incorrect responses. The results showed that humans and Zebra finches are probably using the same methods of learning depending on the categorization tasks that they are exposed to. If Zebra Finches are actually able to acquire (RB) and (II) category structures using the same strategies as humans, the utility of multiple systems of categorization might not be restricted to primates as current literature suggest.
TRANSPORTIN1 Promotes the Association of MicroRNA with ARGONAUTE1 in Arabidopsis
Authors: Cui Yuwei , Fang Xiaofeng , Qi Yijun 
Published: September 2016

Abstract
In Arabidopsis thaliana, microRNAs (miRNAs) are mainly loaded into ARGONAUTE1 (AGO1) to posttranscriptionally regulate gene expression. We previously found that ENHANCED MiRNA ACTIVITY1 (EMA1), an importin β family protein, negatively regulates miRNA loading into AGO1. In this study, through a suppressor screening of ema1, we identified another importin β protein, TRANSPORTIN1 (TRN1), as a regulatory component in the miRNA pathway. Mutation of TRN1 did not reduce miRNA accumulation, but it impaired miRNA activity. We found that TRN1 interacted with AGO1. Mutation of the three conserved residues required for cargo recognition of TRN1 reduced its interaction with AGO1 and compromised its function in regulating miRNA activity. Intriguingly, TRN1 dysfunction did not change the cytoplasmic-nuclear distribution of miRNAs and AGO1 but reduced the amount of miRNAs associated with AGO1. These results indicate that TRN1 positively regulates miRNA activity by promoting the association of miRNAs with AGO1, and they reveal opposing roles of two importin β family proteins in miRNA loading.
The library and the academic resource center
Authors: Pun Raymond 
Published: September 2016

Purpose
– This paper aims to explore the library’s on-going relationship with the academic resource center (ARC), and how over the past two years, there have been new services and programs thriving as a result of this collaboration. The paper presents three case studies that demonstrate the library’s collaboration with the ARC and assesses the opportunities and challenges in working with this department in a new university.

Design/methodology/approach
– The approach of this paper is to explore three case studies on how the library collaborated with the ARC in supporting students. The case studies explore the opportunities for partnerships in developing innovative services, programs and resources. Librarians are integral members of the ARC and are embedded in this community by providing support to the department as well.

Findings
– The paper finds that collaborations between the library and the ARC are mutually beneficial: academic libraries may consider partnering with tutoring centers to create synergies in enhancing the students’ research experience. However, not all collaborative projects or programs are successful or repeatable in success. They are still opportunities to build and strengthen the relationship between the library and the ARC.

Originality/value
– This paper presents three case studies on how the library works closely with the “Global Academic Fellows” (GAF) from the ARC. The GAFs work closely with faculty and librarians as they teach, tutor and collaborate with different university departments to create programs or initiatives that enrich the student experience and the university. Their roles have been instrumental in collaborating with the library to create innovative programs, events and support services throughout the two years since the university opened in 2013.
The usability study on the multicultural children’s book project of the National Library for Children and Young Adults (NLCY) in Korea
Authors: Jeong Wooseob 
Published: September 2016

Purpose
– The purpose of this study is to identify usability issues on a storytelling digital library with six languages provided by the National Library for Children and Young Adults (NLCY) in Korea, and to provide suggestions for future improvement to create a better interface.

Design/methodology/approach
– In this study, usability issues at the multicultural children’s book project Web site of the NLCY were identified, with comparison between the previous interface and the current one, based on the findings of established literature on children’s use of computer applications and web interface.

Findings
– Suggestions for improvements include brighter colors, bigger fonts and graphics, more lively animation and sound, easier navigation, consistent interface, summary availability, better organization of information and labeling and multilingual searching and browsing function. A user study is being planned for future development.

Originality/value
– There is a great value in making 400 children’s books available to the public at the NLCY digital library in six different languages with their original pictures animated and their stories performed in a storytelling mode. However, to provide more pleasant access to the valuable site, particularly for children users, there is much room for improvement in terms of the user interface. Based on these findings, a user study is being planned for future development, which should be more intuitive for users, particularly children.
Migrating a specialized locally created database into WorldCat
Authors: Nelson David N. , Hansard Larry , Turney Linda 
Published: September 2016

Purpose
– The purpose of this paper is to describe the process and the personnel skills required for converting a non-MARC database file into a MARC file for uploading to both OCLC and a local catalog. It also examines the various decisions that need to be made when mapping from one file structure to another.

Design/methodology/approach
– Applied–Database record conversion.

Findings
– While MARCEDIT is a remarkably powerful tool for cataloging and database maintenance purposes, dealing with non-MARC records requires additional programming skills and tools for the successful completion of a file conversion project.

Practical implications
– Discusses the importance of converting locally produced databases, especially those with bibliographic content, to national and international standards to significantly increase their discoverability.

Originality/value
– Provides an overview of file conversion issues and considerations.
Separation of novel phosphoproteins of Porphyromonas gingivalis using phosphate‐affinity chromatography
Authors: Izumigawa Masashi , Hasegawa Yoshiaki , Ikai Ryota , Horie Toshi , Inomata Megumi , Into Takeshi , Kitai Noriyuki , Yoshimura Fuminobu , Murakami Yukitaka 
Published: September 2016

ABSTRACTPhosphorylation of serine, threonine and tyrosine is a central mechanism for regulating the structure and function of proteins in both eukaryotes and prokaryotes. However, the action of phosphorylated proteins present in Porphyromonas gingivalis, a major periodontopathogen, is not fully understood. Here, six novel phosphoproteins that possess metabolic activities were identified, namely PGN_0004, PGN_0375, PGN_0500, PGN_0724, PGN_0733 and PGN_0880, having been separated by phosphate‐affinity chromatography. The identified proteins were detectable by immunoblotting specific to phosphorylated Ser (P‐Ser), P‐Thr, and/or P‐Tyr. These results imply that novel phosphorylated proteins might play an important role for regulation of metabolism in P. gingivalis.
Joint up/down decomposition and reconstruction using three‐component streamers with or without ghost model: the sampling theory
Authors: Tang Zijian , Campman Xander 
Published: September 2016

ABSTRACTThis paper addresses two artefacts inherent to marine towed‐streamer surveys: 1) ghost reflections and 2) too sparse a sampling in the crossline direction. A ghost reflection is generated when an upcoming reflection bounces off the sea surface back into the sensors and can, in principle, be removed by decomposing the measured wavefield into its up‐ and downgoing constituents. This process requires a dense sampling of the wavefield in both directions along and perpendicular to the streamers. A dense sampling in the latter direction is, however, often impossible due to economical and operational constraints. Recent multi‐component streamers have been designed to record the spatial gradients on top of the pressure, which not only benefits the wavefield decomposition but also facilitates a lower‐than‐Nyquist sampling rate of the pressure. In this paper, wavefield reconstruction and deghosting are posed as a joint inverse problem. We present two approaches to establish a system matrix that embeds both a deghosting and an interpolation operator. The first approach is derived with a ghost model, whereas the second approach is derived without a ghost model. The embodiment of a ghost model leads to an even lower sampling rate but relies on a more restrictive assumption on the sea surface.
tipdatingbeast: an r package to assist the implementation of phylogenetic tip‐dating tests using beast
Authors: Rieux Adrien , Khatchikian Camilo E. 
Published: September 2016

AbstractMolecular tip dating of phylogenetic trees is a growing discipline that uses DNA sequences sampled at different points in time to coestimate the timing of evolutionary events with rates of molecular evolution. In this context, beast, a program for Bayesian analysis of molecular sequences, is the most widely used phylogenetic tool. Here, we introduce tipdatingbeast, an r package built to assist the implementation of various phylogenetic tip‐dating tests using beast. tipdatingbeast currently contains two main functions. The first one allows preparing date‐randomization analyses, which assess the temporal signal of a data set. The second function allows performing leave‐one‐out analyses, which test for the consistency between independent calibration sequences and allow pinpointing those leading to potential bias. We apply those functions to an empirical data set and supply practical guidance for results interpretation.
Predictive modelling of ecological patterns along linear‐feature networks
Authors: Ladle Andrew , Avgar Tal , Wheatley Matthew , Boyce Mark S. 
Published: September 2016

Summary

Ecological patterns and processes often take place within linear‐feature networks, and this has implications when analysing the spatial configuration of such patterns or processes across a landscape.

One such pattern is the use of landscapes by human recreationists: an important variable in animal habitat selection and behaviour. Due to the difficulty in obtaining data, ecologists tend to use coarse metrics such as linear‐feature density, while the extent and timing of human activity are often ignored. Remote detector equipment and its increasing use in ecological studies allow for large volumes of data on human activity to be collected. However, the analysis of these data still can be challenging.

Using a combination of generalised linear mixed‐effects models and network‐based ordinary kriging, we developed a method for estimating spatial and temporal variations in motorised and non‐motorised activities across a complex linear‐feature network. Trail cameras were set up between 2012 and 2014 and monitored motorised and non‐motorised activities at 238 different trail sites across a 2824 km2 region of the eastern slopes and foothills of central Alberta's Rocky Mountains.

We evaluate the predictive capacity of this approach, demonstrate its application and discuss its merits and limitations. This method offers a straightforward analysis that can be applied to remotely acquired data to give a useful metric for assessing wildlife responses to human activity, and has potential application beyond the highlighted example.
Adalimumab or infliximab as monotherapy, or in combination with an immunomodulator, in the treatment of Crohn's disease
Authors: Cosnes J. , Sokol H. , Bourrier A. , Nion‐Larmurier I. , Wisniewski A. , Landman C. , Marteau P. , Beaugerie L. , Perez K. , Seksik P. 
Published: September 2016

SummaryBackgroundThe comparative efficacy of adalimumab (ADA) and infliximab (IFX) in Crohn's disease, and the benefit of initial combotherapy with an immunomodulator, are debated.AimTo assess the best anti‐TNF treatment regimens in Crohn's disease.MethodsWe included 906 biologic‐naïve Crohn's disease patients [median age, 31 years (24–41)] and performed a retrospective analysis of 1284 therapeutic exposures to ADA (n = 521) or IFX (n = 763) between 2006 and 2015. An immunomodulator was associated during the first 4–6 months (initial combotherapy) during 706 therapeutic exposures (55%). Median duration of anti‐TNF therapy was 39 months (IQR 17–67). Primary outcomes were 6‐month and 2‐year response rates and drug survival. Logistic regression with propensity scoring and Cox proportional hazard analysis determined variables associated with outcomes.ResultsThe response rates at 6 months and 2 years were 64% and 44% on ADA mono, 86% and 70% on ADA combo, 72% and 45% on IFX mono, and 84% and 68% on IFX combotherapy, respectively. Differences between ADA and IFX were not significant, whereas combotherapy was superior to monotherapy (P < 0.001). Drug survival was longer with combotherapy vs. monotherapy [adjusted hazard ratio 2.17 (1.72–2.70)] and not significantly different between ADA and IFX. During subsequent anti‐TNF exposures, IFX combotherapy fared better than other groups regarding response rates, drug survival, disease activity, hospitalisations and abdominal surgery.ConclusionIn this retrospective analysis of a large tertiary centre cohort of Crohn's disease patients, ADA and IFX had similar efficacy as first line treatment, while initial combotherapy with an immunomodulator improved all outcome measures.