bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and risk factors of postpartum depression among preterm infant mothers
Authors: Ellouze S. , Aloulou J. , Thabet A. Ben , Halouani N. , Gargouri A. , Amami O. 
Published: June 2017

IntroductionThe birth of a preterm infant evokes considerable psychological distress in mothers and is associated with an increased risk for postpartum depression.ObjectivesThe aim of this study was to assess the prevalence of postnatal depression among preterm infant mothers and to identify highlighting associated factors.MethodsWe conducted a cross-sectional, descriptive and analytical study, including 97 mothers of premature infants who presented to the outpatient unit of neonatology at the UH Hedi Chaker of Sfax in Tunisia. For each mother, we collected sociodemographic and obstetric data. We used the Edinburgh Postnatal Depression Scale (EPDS) for screening postpartum depression.ResultsAverage age of mothers was 30.2 years. Average gestational age was 32.82 weeks. Almost all the mothers were married (99%), had a satisfactory couple relationship (93.7%), almost two thirds were multiparous (64.9%), and 77.3% gave birth by caesarean section. Prematurity was unexpected by 56.7% of women. Regarding newborns, digestive problems were noted in 25.8% of cases and sleep disturbances in 20.6% of them. Prevalence of depression in the population studied was 39.2%. It was significantly associated with unexpected prematurity (P < 0.001), impaired couple relationship (P = 0.001), digestive problems (P = 0.013) and sleep disturbances (P = 0.002).ConclusionMothers of preterm infants seem to be particularly vulnerable to postpartum depression. Systematic screening for depressive symptoms in this obstetric population can help to have an optimal psychological outcomes for mothers and infants during a crucial period of development of mother–infant coregulation.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Depression among elderly cancer patients
Authors: Ghanmi L. , Aloulou S. , Mechri A. , Zitoun K. , Hmida A. Ben , Zouari L. , Maalej M. 
Published: June 2017

IntroductionDepression is one of the most common mental illnesses in the elderly and its consequences are severe.AimsTo measure the prevalence of depression in elderly cancer patients and subsequently determine the sociodemographic and clinical factors correlated with this disorder.MethodsWe conducted a descriptive and analytical cross-sectional study of patients aged over than 65 years old, suffering from cancer and who had no cognitive impairment, admitted in 2013 in the Oncology and palliative care unit of Gabes regional Hospital (Tunisia). We used a self-rating questionnaire to detect sociodemographics and clinical variables, the Geriatric depression scale (GDS) to assess depressive symptoms, and the Activity of Daily Living to determine the degree of autonomy.ResultsAt the end of our investigation, we included 60 patients. The prevalence of depression was 48%. Depression was significantly correlated with: marital status (widower subjects were more depressed (74% vs. 34%, P = 0.007)), less degree of autonomy (80% vs. 38%, P = 0.04), fatigue (62% vs. 26%, P = 0.007), pain (59% vs. 26%, P = 0.02), family psychiatric history (80% vs. 20%, P = 0.02), family history of death by cancer (72% vs. 38%, P = 0.01), WHO condition (67% vs. 34%, P = 0.04) and the presence of co morbidity in particularly diabetes (69% vs. 41%, P = 0.05).ConclusionDepression is prevalent in oncogeriatric environments. This could compromise quality of support and care of these patients. Close collaboration between oncologist and psychiatrist is needed to support and relieve these patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Seasonal affective disorder (SAD) and light therapy: State of the science
Authors: Glod C. 
Published: June 2017

Major depression with a fall/winter seasonal pattern, also known as seasonal affective disorder (SAD), is a recurrent and prevalent disorder. Treatment may include either pharmacological (antidepressant) or non-pharmacological options, most commonly light therapy. Over the years, light therapy has been explored using various delivery methods including light-emitting diode (LED) devices. For over 20 years, cool-white fluorescent sources that yield 10,000 lux of polychromatic white light have been the standard treatment for SAD. Many investigations have confirmed the clinical effectiveness of white light, its overall tolerability, and adverse reactions, such as agitation, insomnia, and headache. Building upon this, more recent studies have compared alternative light sources and different wavelengths of light, such as white, red, green, and blue. If certain wavelengths are more potent and effective, lower intensities of light could reduce side effects and increase tolerability and adherence. Furthermore, studies of the ocular system particularly, intrinsically photosensitive retinal ganglion cells, discovered differences among specific wavelengths of light. While some reports have suggested that 446–477 nm wavelengths of blue light may be the most potent, published clinical trials have revealed mixed results. The purpose of this session is to review the state of the science on light therapy in the treatment of SAD, and suggest recommendations for clinical practice and implications for patients.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Body appreciation: A buffer against the impact of shame on depression
Authors: Marta-Simões J. , Ferreira C. , Mendes A.L. 
Published: June 2017

Shame is defined as a painful affect, associated with the perception that one's personal characteristics and/or behaviours are seen by others as unattractive. Since it signals the possibility of rejection, high levels of shame associate with high psychological suffering and several psychopathological conditions, namely depression. In contrast, body appreciation is considered a set of attitudes of acceptance and affection towards one's body image, even when one is displeased with certain body characteristics, being therefore a disposition to self-soothing and care. Taking into account the association of body appreciation with healthy mental functioning, this study aimed at exploring the buffering effect of body appreciation against shame's impact on the display of depression symptoms. This hypothesis was tested through path analysis in a community sample of adult men and women. Results revealed body appreciation as a significant moderator of the association between external shame and depressive symptomatology. The tested model explained 45% of the variance of depressive symptomatology. A graphical representation allowed understanding that this moderator effect is particularly expressive in those who experience medium to high levels of shame. In these cases, men and women who present higher body appreciation tend to display fewer depression symptoms. These results seem to emphasize the importance of establishing a positive relationship with one's own body image, which appears to be protective either for men's and women's mental health. Considering its buffering effect of shame's impact on depression, upcoming interventions in this area could benefit from the assessment and cultivation of positive body image.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Comorbid depression and ulcerative colitis – is there a connection?
Authors: Melada A. , Krišto-Mađura I. , Vidović A. 
Published: June 2017

Ulcerative colitis (UC) is a subset disorder of inflammatory bowel disease (IBD) with chronic course and symptoms such as fatigue, gastrointestinal pain, fever, etc. IBD is associated with psychological manifestations including depression and anxiety. There is an increased number of studies trying to link these comorbidities. The gut-brain axis is regulated by intestinal microbiota and this bidirectional communication including immune, neural, endocrine and metabolic mechanisms may bring us closer to the answer. The following case concerns a 56-year-old patient with history of major depressive disorder who was in continuous psychiatric care and treated with antidepressants. Several years after the beginning of psychiatric treatment, he was hospitalized for diagnostic examination due to subfebrility of unknown etiology, but with no final somatic diagnosis. After two years he was referred to our department and at administration the patient showed symptoms of depression, anxiety, lack of motivation and suicidal thoughts and tendencies. Subfebrility was still present at that time. His psychopharmacotherapy was revised and there was a slight improvement in mood and behaviour. During outpatient follow-ups the symptoms of depression were still prominent and remission was not achieved even with modulation of antidepressant pharmacotherapy. The following year the patient was diagnosed with UC and started specific treatment after he presented with diarrhea in addition to subfebrility. Subsequently his mood improved, suicidal thoughts were diminished and ultimately remission was achieved. This case suggests that only after UC was being treated the psychiatric symptoms also withdrew which implicates that inflammatory mediators were involved in pathogenesis of depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Personality disorders and affective temperament in unipolar and bipolar mood disorder
Authors: Nivoli A. , Floris L. , Antonioli M. , Folini L. , Nivoli L.F. , Milia P. , Vento L.I. , Depalmas C. , Lorettu L. 
Published: June 2017

IntroductionPersonality disorders (PD) and Affective temperaments (AT) have been considered vulnerability factors for the development of mood disorder (MD).ObjectiveTo study the simultaneous presence of PD and AT in patients with DU and differences between unipolar depression (DD) and bipolar disorder BD.MethodsAn observational study was conducted. Patients were administered the Temperament Evaluation of Memphis, Pisa, Paris and San Diego questionnaire (TEMPS-A) for AT and the Structured Clinical Interview for DSM IV Axis II Disorders (SCID-II) for PD. The interrelationships of the different PD and AT were studied by factor analysis (principal component analysis, PCA) (orthogonal rotation, Varimax).ResultsParticipants were 156 adult patients with MD, 37.1% with DD and 62.9% with BD. DD patients presented with significantly more paranoid PD (P = 0.009), depressive (P = 0.029), anxious (P = 0.009) and irritable temperament (P = 0.006) compared to BD. PCA results showed four significant factors, explaining the 63.1% of total variance, corresponding to four potential groups of patients with specific PD and AT associations.ConclusionThe comorbidity between MD and PD and AT may differentiate DD from BD. Specific patterns of comorbidity may be useful as they may substantially influence the course of the mood disorders and how patients respond to treatment.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Exploring perinatal depression symptom clusters as predictors of childbearing outcomes
Authors: Records K. , Rice M.J. , Apugan Z.D. 
Published: June 2017

IntroductionPerinatal depression is related to poorer outcomes for women and their children. Measurement indices that categorize perinatal depression as present or absent are commonly used in clinical practice and research efforts. Categorization minimizes the health effects of potentially different symptom clusters and may confound understanding of health outcomes.ObjectivesThe objective of this investigation is to explore the symptom clusters resulting from administering two commonly used depression screening instruments during pregnancy and postpartum.Aims(1) Identify the depressive symptom clusters for perinatal depression; (2) Test whether symptom clusters predict maternal and newborn outcomes, and if so, whether these differ from categorization analytics.MethodsA secondary analysis was conducted on data from a longitudinal study of 139 women. They participated from their 3rd trimester of pregnancy through 8 months after birth and completed surveys at five times using the center for epidemiologic studies Depressed Mood Scale (CES-D) and the Edinburgh Postnatal Depression Survey (EPDS). Analysis procedures included cluster analysis and hierarchical regression.ResultsIndividual symptoms were reported by 2.9–31.7% of the sample. Separate clusters (CES-D = 4; EPDS = 2) were identified and, of these, two clusters were primary predictors of maternal and newborn outcomes. Results differed from that obtained with cut-score analytics.ConclusionsExamination of depression symptom clusters as related to health outcomes during childbearing has significance for clinical practice and research, particularly for women who would not score as depressed on established screening instruments.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Folate and pyridoxine to ssri in major depression and residual cognitive Decline
Authors: Savic V. , Golubovic O. , Nikolic S. 
Published: June 2017

IntroductionDepressive disorders are very common conditions, lifetime risk for experiencing major depression is approximately 15%.ObjectivePatients with major depression having an insufficient response to SSRI may benefit from addition of methylfolate and pyridoxine.AimThe aim of our study was to determine the effect of folate and pyridoxine augmentation to SSRI on emotional, physical and cognitive symptoms in major depression.MethodsEighteen patients with MDD were enrolled, were on citalopram 20 mg/day when folate/15 mg per day/and pyridoxine/40 mg per day/were added. They have been monitored for three months using standard scales for depression and assessment by interview.ResultsAfter three months of using folate and pyridoxine to SSRI there was a significant improvement in depression as measured by the scales. In 8 patients were recorded improvements of 30–50%. The most prominent changes were in cognitive sphere of depression such as attention, reasoning and problem solving, working memory and speed of processing.ConclusionLow levels of folate and pyridoxine have been associated with the presence of depression and residual poor cognitive function. Our study confirms that folate and pyridoxine as adjunctive therapy to SSRI-partially refractory major depression is useful in particular to issues of residual cognitive interference conditions such as impaired concentration and memory, slow mentation, attention/vigilance, problem solving, working memory and speed of processing.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Clinical and neurocognitive characteristics associated with treatment-resistant depression
Authors: Serafini G. , Adavastro G. , Canepa G. , Conigliaro C. , Pompili M. , Girardi P. , Amore M. 
Published: June 2017

IntroductionTreatment resistant depression (TRD) is a disabling condition associated with a relevant psychosocial impairment worldwide.ObjectivesThis exploratory study is aimed to evaluate the main clinical and neurocognitive characteristics in a sample of 21 subjects admitted to the Psychiatric Clinic of University of Genoa as inpatients between 2015 and 2016 and diagnosed with TRD according to Thase and Rush staging method.MethodsPatients have been assessed using the Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale, and Clinical Global Impression (CGI). The Continuous Performance Test (CPT), Trial Making Test (TMT-A/B), Stroop Color Word Interference Test, Verbal Fluency Test, and Rey auditory-verbal learning test (RAVLT) have been administered as well.ResultsSubjects with early-onset (< 50 years) depression had a longer illness duration, higher depressive episodes and more impaired performance at RAVLT while individuals with late-onset (> 50 years) depression showed a higher severity of depressive symptoms and more anxiety symptoms. Depressive symptoms were positively associated with anxiety (r = 0.82; P = 0.00) and negatively with TMT-A/B (r = −0.56, P = 0.01), Stroop Color Word Interference Test (r = −0.72, P = 0.005 and r = −0.616, P = 0.008), and RAVLT (r = −0.60; P = 0.02) performances. According to regression analyses, anxiety symptoms were the only significant predictor of depression severity (P = 0.02).ConclusionsEarly-onset depression is associated with more disability and worse neurocognitive performance whereas late-onset depression is linked to more anxiety symptoms and more depressive symptoms severity. Clinicians should closely monitor patients with TRD for the presence of anxiety symptoms that may represent a significant risk factor of poorer long-term outcome.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Depression screening in primary care patients
Authors: Thabet J. Ben , Turki M. , Mezghanni M. , Bouali M. Maalej , Charfi N. , Omri S. , Zouari N. , Zouari L. , Maalej M. 
Published: June 2017

IntroductionDepression is a common mental disorder that can be associated with more functional disability than most chronic medical illnesses and the increased reporting of medically unexplained somatic symptoms.AimTo assess the prevalence of depression in a Tunisian population, as well as the associated factors.MethodsWe conducted a cross-sectional, descriptive and analytic study, among 707 subjects consulting in 20 primary care units in Sfax and Tunis, Tunisia. These participants, randomly chosen, were asked to answer a questionnaire after their consent. Depressive symptoms were evaluated using the “Beck Depression Inventory” (BDI).ResultsThe mean age of participants was 39.84 years. Among them, 38.6% had a low educational level (illiterate or primary school level); 45.3% were professionally inactive and 92.9% had a low to medium socio economic level. Medical, psychiatric and suicide attempt histories were reported respectively in 51.2%, 7.6% and 1.8% of cases. According to BDI, a mild depression was noted in 22.9%; moderate 16.1%; severe 4.1%. Among those presenting a moderate to severe depression (MSD), only 16.8% were followed up in psychiatry, 4.2% were receiving antidepressant and 9.8% benzodiazepine. MSD was associated with low educational level (P < 0.001); low to medium socio economic level (P < 0.001); psychiatric histories (P < 0.001); suicide attempt histories (P < 0.001); somatic histories (P < 0.001).ConclusionOur study highlighted a high prevalence of depression that is still under diagnosed and therefore poorly managed. General practitioners should be made aware of the importance of screening for depression in medical patients because it not only complicates their overall medical treatments, but also impedes their physical and social functioning.Disclosure of interestThe authors have not supplied their declaration of competing interest.
The ICT4LIFE Project–Design and development of a new information technology platform for patients with Alzheimer's disease
Authors: Osvath P. , Voros V. , Kovacs A. , Greges I. , Fekete S. , Tenyi T. , Fekete S. ,   C.ICT4Life
Published: June 2017

AimWith an increasingly growing population in Europe, cognitive impairment is a major social and health issue. According to the World Alzheimer Report (WHO, 2014), dementia, including Alzheimer's disease is one of the biggest global public health challenges our generation is facing. There are many efforts at European level to promote active and healthy ageing. This three-year project has the ambition to provide new services for integrated care with breakthrough research and radical innovation by employing user-friendly Information and Communication Technology (ICT) tools, ultimately increasing patients’ quality-of-life and autonomy at home.MethodsICT4Life proposes an innovative platform for integrated care by the use of sensor-based analytics for human behaviour. Novel ICT services are used to determine the relation between cognitive decline, related psychopathological symptoms and the quality-of-life of the patients, and to assess how these affect patients’ and caregivers’ daily living. ICT4Life platform uses advanced sensor-based analytics; to maximize elderly empowerment and self-care abilities thanks to a properly designed and reconfigurable recommendation system that will be able to exploit user-generated data; and to improve decision-making processes in care professionals’ daily activities. All solutions are developed following a user-centred methodology and tested in real-life scenarios.ResultsThe study design and the preliminary results of the ICT4Life project are presented on the poster.ConclusionICT4Life programme develops a solution for individuals with early stage cognitive impairment that will permit doctors and caregivers to extract useful information about patients, while contributing in a user-friendly way to extending their independence.Disclosure of interestCOI: This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N° 690090. Tamas Tenyi and Sandor Fekete are supported by the National Brain Research Program Grant N° NAP KTIA NAP-A-II/12.
Non-invasive brain stimulation treatment in a group of adolescents with anorexia
Authors: Costanzo F. , Maritato A. , Menghini D. , Castiglioni M.C. , Zanna V. , Vicari S. 
Published: June 2017

IntroductionAnorexia nervosa (AN) is characterized eating behaviors and body image disturbances. Given poor treatment outcomes are available for AN, treatment innovations are urgently needed. Recently, non-invasive neuromodulation tools have suggested having potential for reducing AN symptomatology targeting brain alterations.ObjectivesThe objective was to verify whether an excitatory transcranial direct current stimulation (tDCS) over the left prefrontal cortex may aid in altering/resetting inter-hemispheric balance in AN patients, re-establishing control over eating behaviors.AimsResearch is aimed to evaluate the potential of tDCS treatment in determining a more rapid improvement compared to classical treatments in adolescents with AN.MethodsTwenty-two adolescents with AN, underwent the treatment as usual (AU) plus the tDCS treatment (TDCS + AU: n = 8, age M 13.7 ± 1.9 years) or a family therapy (FT + AU: n = 14, age M 15.1 ± 1.75 years), for six weeks. Psychopathological scales (EDI-III, EAT 26, BUT, MASC, CDI) and anthropometric indicator of nutritional status (BMI) were assessed before and after treatment.ResultsBMI improved only in the TDCS + AU group (P < 0.01). Mean BMI percentage of improvement was 14.43% + 10.8 in the TDCS + AU and 4.83% ± 5.4 in the FT + AU. Both groups improved in the total scores of the EDI, EAT-26, MASC and CDI scales (all P < 0.01).ConclusionstDCS treatment improved BMI values more than classical treatment and determined comparable to the classical treatment improvement in the psychopathological scales. This results may be an important starting point to further explore the beneficial effect of brain based treatments for AN.Disclosure of interestThe authors have not supplied their declaration of competing interest.