bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyphenol-Mediated Modulation of Non-Coding RNAs: A New Therapeutic Approach for Hypertension - A Review
Authors: Gareev Ilgiz , Beylerli Ozal , Ilyasova Tatiana , Wang Chunlei 
Published: September 2024

:
Hypertension (HTN) is a leading risk factor for cardiovascular diseases (CVDs) and a
major contributor to global morbidity and mortality. Conventional pharmacological treatments
have been effective but are often accompanied by side effects and do not address all pathological
aspects of the disease. Recent advances in molecular biology have identified non-coding RNAs (ncRNAs),
including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), as key regulators
in the pathogenesis of hypertension. These ncRNAs influence various cellular processes, such
as gene expression, vascular tone, and inflammation, making them promising targets for therapeutic
intervention. This review explores the potential of polyphenols, a diverse group of phytochemicals
with potent antioxidant and anti-inflammatory properties, in modulating ncRNA expression
and function. We discuss how polyphenols, such as epigallocatechin-3-gallate (EGCG), resveratrol,
curcumin, and quercetin impact the regulation of ncRNAs, particularly focusing on their roles
in reducing oxidative stress, improving endothelial function, and ameliorating vascular remodeling
associated with hypertension. The review synthesizes current evidence from both in vitro and
in vivo studies, highlighting significant findings and the mechanisms by which polyphenols exert
their effects on ncRNA-mediated pathways.

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Moreover, we address the challenges of translating these findings into clinical applications, including
issues related to bioavailability, dosing, and the complex interactions of polyphenols with
other cellular components. Future directions for research are suggested, with an emphasis on the
need for comprehensive clinical trials to establish the efficacy of polyphenol-based therapies targeting
ncRNAs in hypertension management. By targeting ncRNAs, polyphenols offer a novel
therapeutic strategy that could enhance the treatment landscape for hypertension and potentially
other cardiovascular conditions.
Blockchain Security:"Botnets and Bitcoin Mining” - A Study on the Impacts and Countermeasures
Authors: Kundu Krishanu 
Published: September 2024

Introduction:
Botnets have become a significant threat to cybersecurity, as they can
be used for a wide range of malicious activities, including Distributed Denial-of-Service (DDoS)
attacks, spamming, and cryptocurrency mining. Bitcoin Mining, in particular, has become a
lucrative target for cybercriminals, as it requires massive computing power and can generate
significant profits.

Methods:
In this paper, the author presents a study on a botnet that uses an HTA file to gain
initial access and execute code on a victim's device, followed by the installation of mining
software to infect the device and bitcoins.

Results:
The author analyzes the botnet's behaviour, including its evasion techniques and Bitcoin Mining
activities, and discusses the implications of current findings for cybersecurity and Bitcoin Mining.

Conclusion:
Future research should also investigate the use of different command and control
servers and other advanced attack frameworks in botnet operations and examine the potential
connections between botnets and other cybercrime activities, such as ransomware and espionage.
From Enzyme to Vaccine: Preliminary Insights into the Immunogenic Epitopes in Adenylate Kinase 8 (ADK8) of Echinococcus granulosus
Authors: Ghamazi Nilofar , Azimi-Resketi Mojtaba , Najafi Alireza , Ghiabi Shadan , Asghari Ali , Fathollahzadeh Mohammad , Majidiani Hamidreza 
Published: September 2024

Background:
Globally, developing livestock countries are affected by Cystic Echinococcosis
(CE), a neglected zoonosis. Thus, vaccination would help to prevent this neglected zoonosis.

Objective:
This study aimed to predict the primary biochemical characteristics of E. granulosus
Adenylate Kinase 8 (ADK8) and its potential B- and T-cell-binding epitopes as a candidate for
vaccination.

Methods:
Prediction were conducted on multiple web servers to identify immunogenic epitopes as
well as biochemical, antigenic, structural, and subcellular properties.

Results:
The extracellular 38.78 KDa protein possessed no allergenic fragments, while it showed
hydrophilicity (GRAVY: -0.239), wide thermotolerance (aliphatic: 98.02), and 36 post-translational
modification sites. The secondary structure mostly included helices and random coils, and the
best-generated 3D model by the Robetta server had a confidence score of 0.79. Three servers identified
common B-cell epitopes and evaluated them for solubility, allergenicity, and antigenic properties.
Furthermore, following the screening, MHC-associated epitopes for humans and mice were
predicted in the E. granulosus ADK8.

Conclusion:
These results provide a basis for future research into the development of a proper
vaccine against CE. Additional empirical studies using the protein and/or its epitopes alone or in
combination with additional antigens are demanded.
The Digitalization of Social Care in England and Implications for Older, Unpaid Carers: Constructionist Thematic Analysis
Authors: Rousaki Anastasia , Zamani Efpraxia D , Sbaffi Laura , Hamblin Kate , Black Rachael 
Published: September 2024

Background
Globally, populations are aging, generating concerns about the sustainability of health and social care provision. In terms of the public provision of social care in particular, unpaid carers provide much of the support to people with disabilities and older people. In addition, there is an increased onus in many countries on digital transformation projects, in the hope that the digitalization of services can create efficiencies and savings in both costs and care labor. In England, the focus of this paper, the shift to digital services is also framed as a means to enhance choice and control for older unpaid carers, while being part of a broader offering that includes nondigital alternatives and support to mitigate digital exclusion.

Objective
This study examines the impact of digitalization on older, unpaid carers—a group more likely to be both expected to engage digitally with services and at risk of digital exclusion—in England, focusing on their lived experiences in terms of caring and access to social care.

Methods
We used a constructionist approach to thematic analysis, where data from 48 older unpaid carers collected through focus groups were analyzed using thematic analysis, resulting in 4 prevailing themes.

Results
Our findings indicated that while unpaid carers largely acknowledge the benefits of digitalization, they also highlight several points of failure, whereby engagement with digital spaces is experienced as coercive and exacerbates feelings of exclusion. These are further worsened by government failures to address issues of connectivity, imposing additional financial burdens and complicating tasks such as benefit applications.

Conclusions
In this study, we have highlighted the need for greater involvement in shaping both policy and technological solutions, which in turn will be more inclusive and aligned to the aspirations and circumstances of older carers.
DONZELA-GUERREIRA? IMAGINÁRIO LITERÁRIO BRASILEIRO SOBRE BALTASAR DO COUTO CARDOSO/MARIA ÚRSULA DE ABREU E LENCASTRO
Authors: Maia Helder Thiago 
Published: September 2024

Após breve apresentação sobre os estudos literários em torno das donzelas-guerreiras, e sobre o lugar ocupado por Baltasar do Couto Cardoso/Maria Úrsula de Abreu e Lencastro (1682-1730) dentro dessa perspectiva crítica, examinamos textos históricos e literários brasileiros que narram a vida dessa personagem. Estamos interessados não só em perceber as repetições e as rupturas entre o discurso histórico e o literário, mas também em observar como é narrado o trânsito de gênero de Baltasar/Maria Úrsula. Nesse sentido, foram analisados dezenove textos históricos, publicados entre 1822 e 1955, além do romance A Senhora de Pangim (1932), de Gustavo Barroso, e da revista em quadrinhos A Senhora de Pangim (1956), de Gutenberg Monteiro e Gustavo Barroso.
AS MULHERES NA GESTÃO DO IFSC - CÂMPUS FLORIANÓPOLIS
Authors: Kaminski Corso Gizelle 
Published: September 2024

Esta pesquisa objetiva apresentar dificuldades, desafios e reflexões das mulheres na gestão do Instituto Federal de Santa Catarina - Câmpus Florianópolis. É uma pesquisa de abordagem qualitativa e quantitativa, realizada por meio de fontes bibliográficas, documentais e aplicação de questionário. Como resultado principal, constatou-se que a maioria das servidoras não recebeu formação específica para atuar na gestão e não se sentia preparada para o cargo. Os maiores desafios estavam relacionados à gestão de pessoas e às relações interpessoais e as maiores dificuldades, ao fato de as servidoras não serem ouvidas e à existência de machismo no âmbito da instituição.
La gestión escolar: una oportunidad que promueve la reflexión sobre las crianzas y fortalece el vínculo entre la escuela y las familias
Authors: Marcos Cayetano Juan Antonio 
Published: September 2024

Para responder a la pregunta ¿Cómo la gestión escolar promueve la reflexión sobre las crianzas y fortalece el vínculo entre la escuela y las familias? Se desplegó un estudio cualitativo de investigación acción en una escuela primaria, lugar donde se organizaron sesiones de trabajo con grupos de padres de familia de los alumnos que convergen en el centro educativo y que representaron los sujetos del estudio, una muestra intencionada de 296 mujeres y 35 hombres.
Como actor que hace posible la gestión en las escuelas de educación básica, se resaltó la colaboración del director escolar con el equipo de USAER para organizar sesiones de trabajo en el marco de “escuela para padres” con el objetivo de fortalecer el vínculo entre la escuela y las familias, y promover la reflexión sobre los estilos de crianza. Dichas sesiones se organizaron en seis momentos, denominados: bienvenida y justificación, confianza y acercamiento, la lectura, los estilos de crianza, una reflexión en grupo y la precepción final a través de dos preguntas a las familias en las que sugieren la organización de más actividades similares. Se concluye que la gestión del director escolar es un camino de colaboración que hace posible el vínculo entre la escuela y las familias a través del establecimiento de estrategias y redes de participación en la comunidad escolar y que los padres de familia muestran interés hacia las actividades que se proponen desde la escuela.
Correction of Grammatical Structure Disorders in Older Preschoolers with Severe Speech Disorders Using Children’s Fiction
Authors: Nigmatullina A. A. 
Published: September 2024

Introduction. Currently, one of the most urgent problems of special education is the development of effective approaches to the correction of violations of grammatical structure of speech in older preschool children with severe speech disorders. The leading activity of this age period is play. It allows the formation of all important mental neo-formations. Thisnecessitates the use of game methods in the process of corrective-developmental activities for older preschool children. Objective. To select a set of correctional techniques, including the use of reading children’s fiction, for the correction of grammatical structure disorders in older preschoolers with severe speech disorders. Materials and Methods. To assess the formation of grammatical skills in older preschoolers, we used an adapted “Methodology of Psycholinguistic Research of Oral Speech Disorders in Children” by R. I. Lalaeva and “Comprehensive Educational Program of Preschool Education for Children with Severe Speech Disorders” by N. V. Nishcheva. Results. The experimental study was conducted with the involvement of 10 children (6 boys and 4 girls) of preschool age with the speech therapy conclusion “erased dysarthria” at the age of 5.5 to 6 years, attending kindergarten No. 52 in Taganrog. The results of the study showed that the use of the developed methods and techniques of speech therapy allowed to develop concentration of attention, diligence in classes and to correct the revealed violations of the grammatical structure of speech, which were manifested at the beginning of the work. Discussion. It was revealed that the use of a large number of visual teaching aids, taking into account individual and age-specific features of older preschool children with severe speech disorders allowed to bring the level of development of children’s speech skills closer to the age norm: they built their answers consistently and logically, and also learned to operate independent speech.
The perfusion index as a method of assessing epidural anaesthesia efficacy in healthy dogs
Authors: Itoh Harumichi , Inoue Hajime , Itamoto Takuya , Tani Kenji , Sunahara Hiroshi , Nemoto Yuki , Nakaichi Munekazu , Iseri Toshie , Itamoto Kazuhito 
Published: September 2024

Abstract

Introduction
Perfusion index (PI) is used as assessment of epidural anaesthesia efficacy in human medicine, but its usefulness in dogs is unknown. The aim of this study was to evaluate the usefulness of PI in determining epidural anaesthesia effectiveness.

Material and Methods
This is prospective cross-over experimental study. Five healthy adult beagle dogs were anaesthetised and an epidural catheter was inserted in the lumbosacral area and adjusted so that the end of the catheter was placed at the fourth lumbar vertebra. Single-port catheters were used in the control group and multiple-port catheters were used in the treatment group. A PI probe was placed on a hind leg, and the catheter placement was confirmed via computed tomography. The treatment group received a bolus dose of lidocaine, and the control group received saline, via epidural catheter. The PI value was recorded every 5 min until 30 min after lidocaine injection.

Results
The PIs of the hind limbs were not significantly different over time, nor were they between the control and lidocaine-injected groups at any point in time.

Conclusion
The PI is not useful in determining the efficacy of epidural anaesthesia in dogs under general anaesthesia. In the future, finding a reliable method to evaluate the success of regional anaesthesia, even in patients under general anaesthesia, will be necessary.
Bacterial microbiome diversity along poultry slaughtering lines: insights from chicken carcasses and environmental sources
Authors: Telli Arife Ezgi , Biçer Yusuf , Telli Nihat , Sönmez Gonca , Turkal Gamze , Güzel İsmail 
Published: September 2024

Abstract

Introduction
This study aimed to determine the bacterial diversity of chicken carcasses and their surrounding environment at various stages along a poultry slaughter line.

Material and Methods
Amplicon sequencing of the 16S rRNA gene was employed to assess the shifts in bacterial community diversity at both phylum and genus levels. Samples were collected from September to November 2021, targeting carcass surfaces at various operational stages (post-defeathering, post-evisceration, post-water chilling, and post-cooling), as well as from the internal environments and air of these units. The study took place in a vertically integrated poultry slaughterhouse in Konya, Turkey.

Results
Microbial diversity increased after the chilling and storage stages as a result of redistribution of the microorganisms after the physical effect of the slaughtering stages. The final product sample taken after storage had the highest bacterial abundance. The abundance at this stage was found to be strongly correlated with that at other slaughtering stages, as well as with the abundance in chilling water and on the personnel’s hands. The common genera in chicken carcasses during slaughter stages were Macrococcus, Acinetobacter, Enterococcus, Escherichia-Shigella, Psychrobacter, Streptococcus, Lactococcus and Ligilactobacillus. Microbiome data in environmental samples indicated that the genera in highest relative abundance were Bacillus, Anoxybacillus, Acinetobacter and Psychrobacter. In air samples, the storage room had the highest diversity and in this place Bacillus spp. and Staphylococcus spp. were in the majority.

Conclusion
This study may provide some useful information to pinpoint the critical contamination sources in the poultry slaughtering process.
Numerical Study on the Effect of Weight Variables on the Roll Damping Coefficients for a Fishing Vessel
Authors: Seo Janghoon , Park Dong-Woo 
Published: September 2024

Abstract
The roll damping coefficient is essential when considering the viscous effect in the potential-based hydrodynamic analysis of fishing vessels; it is an important factor in the roll motion response. The present study performs free roll decay simulations, altering weight variables using Computational Fluid Dynamics (CFD) to investigate the correlation between the roll damping coefficient and the weight variation of a fishing vessel. The time series of roll amplitude and roll damping coefficient are compared, for varying vertical and longitudinal centres of gravity and radii of gyration in roll motion. As the vertical centre of gravity increases, both the roll decay period and the roll damping coefficient also increase. The roll decay period tends to increase with the increase in the radius of gyration during roll motion, while the roll damping coefficient exhibits a decrease. A longitudinal centre of gravity has a limited effect on free roll decay characteristics. The roll damping coefficients between the maximum and minimum combinations of weight variables show significant differences. The findings of the present study could enhance the understanding of the safety of fishing vessels based on their loading conditions. Consequently, future research could further improve the results obtained in the present study by considering various hull shapes and speeds.
Determination of Propeller-Rudder-Hull Interaction Coefficients in Ship Manoeuvring Prediction
Authors: Kołodziej Radosław , Hoffmann Paweł 
Published: September 2024

Abstract
The assessment of ship manoeuvring properties is a crucial part of the process of ship design and is usually first carried out during the model test phase of the project. According to the International Maritime Organisation (IMO), the manoeuvrability of the ship can be assessed on the basis of the standard trial manoeuvres. In order to do this, free running model tests or captive model tests are used, in conjunction with a mathematical model of ship motion; this is considered to be a reliable prediction method. In recent years, numerical-based methods have also been widely used in ship hydrodynamics and constantly improving computing power and more accurate fluid dynamics models have made the simulation of more complex cases possible. The study presented in this paper focuses on the determination of propeller-rudder-hull interaction coefficients based on the Mathematical Modelling Group (MMG) standard method in ship manoeuvring prediction. The identification of the parameters uses both captive model tests and a simplified numerical method, as well as regression formulas. The results of 35° turning and 10°/10° zig-zag manoeuvres, obtained with the use of each prediction method, are then compared. The test case used in the study is the container type cargo ship equipped with a single propeller and rudder. The model scale, for which the referenced model tests were carried out, is equal to 1:25 and a NACA 0020 rudder profile was used. This research highlights the advantages and disadvantages of each presented prediction method and their potential for future improvement.
Increasing the Economic Efficiency of Marine Power Plants Using Waste Heat Boilers with Controlled Flow Separation
Authors: Kuznetsov Valerii , Kuznetsova Svitlana 
Published: September 2024

Abstract
Heat recovery of exhaust gases from main and auxiliary marine diesel engines is an effective way to improve the technical and economic parameters of marine power plants. Improvements in engine efficiency necessitate an increase in the weight-size parameters of the waste heat boilers, which makes it difficult to recover heat. Intensification of the heat transfer process is considered to be an effective way to reduce these indicators. By utilising mathematical modelling, this paper shows the effectiveness of using profiled heating surfaces of waste heat boilers for this purpose. The use of elliptical heating surfaces with a mechanism of controlled flow separation, in the form of a triangular notch, is proposed. This will reduce surface drag and increase the overall thermal-hydraulic efficiency of the heat transfer processes. It is shown that the use of such surfaces in waste heat boilers makes it possible to increase the efficiency of marine power plants in tankers with a deadweight of about 45,500 tons up to 1.5% absolute and container ships with a deadweight of about 122,000 tons up to 2.5% absolute.
Do Chairs Reduce a Navigator’s Mobility? Pilot Study on the Influence of Navigation Bridge Design on Lookout Routines
Authors: Stopa Michał 
Published: September 2024

Abstract
Despite technological progress in the maritime industry, navigators are still the final link of the decision-making chain and rely not only on equipment, but also on human senses. Visual observation of the vessel’s surroundings still plays a crucial role in navigation. Four different ships in service were visited to investigate the work of professional navigators and carry out a pilot experiment on real crews to test the methods for future full-scale research. The main objective was to better understand the influence of bridge design on lookout routines of navigators, while the additional goals were to check the presence of navigators in certain parts of the bridge and to determine if it is reasonable to forbid navigators to sit, as the practice is still used on some ships. Considering space limitations and differences in layouts of the wheelhouse, rarely mentioned in this kind of study, the movement of watch-keeping officers was analysed. In total, twenty observations were made to generate the heatmaps of presence during the routine duties. The results of the research indicate that many factors, including bridge design and layout of equipment, might affect lookout routines but it is possible to find similar patterns on the bridges of different shapes and arrangements. The pilot experiment confirms that it is reasonable to carry out a full-scale study, as there is still room for improvement in the area of ergonomic bridge design. Better understanding of modern lookout and movement routines might lead to the development of adequate ergonomic regulations and result in increased work comfort and the well-being of seafarers.