bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and safety of home exercise training in children with sickle cell anemia
Authors: Liem Robert I. , Akinosun Moriyike , Muntz Devin S. , Thompson Alexis A. 
Published: June 2017

AbstractExercise guidelines do not exist for individuals with sickle cell anemia (SCA) despite the impact of disease‐related complications on physical functioning. Thirteen subjects (mean 15.1 ± 2.8 years old) with SCA were prescribed three exercise sessions/week for 12 weeks on a stationary bicycle placed at home. In total, 77% of subjects completed 89% of prescribed sessions without exercise‐related adverse events, thus meeting feasibility and safety criteria. Adherence to prescribed duration and target heart rate during training decreased during the second half of the study. Future trials are warranted to further evaluate training benefits associated with regular exercise in children with SCA.
Epithelioid hemangioendotheliomas of the liver and lung in children and adolescents
Authors: Hettmer Simone , Andrieux Geoffroy , Hochrein Jochen , Kurz Philipp , Rössler Jochen , Lassmann Silke , Werner Martin , von Bubnoff Nikolas , Peters Christoph , Koscielniak Ewa , Sparber‐Sauer Monika , Niemeyer Charlotte , Mentzel Thomas , Busch Hauke , Boerries Melanie 
Published: June 2017

AbstractEpithelioid hemangioendothelioma (EHE) is a rare, vascular sarcoma. Visceral forms arise in the liver/ lungs. We review the clinical and molecular phenotype of pediatric visceral EHE based on the case of a 9‐year‐old male child with EHE of the liver/lungs. His tumor expressed the EHE‐specific fusion oncogene WWTR1‐CAMTA1. Molecular characterization revealed a low somatic mutation rate and activated interferon signaling, angiogenesis regulation, and blood vessel remodeling. After polychemotherapy and resection of lung tumors, residual disease remained stable on oral lenalidomide. Literature review identified another 24 children with EHE of the liver/lungs. Most presented with multifocal, systemic disease. Only those who underwent complete resection achieved complete remission. Four children experienced rapid progression and died. In six children, disease remained stable for years without therapy. Two patients died from progressive EHE 21 and 24 years after first diagnosis. Natural evolution of pediatric visceral EHE is variable, and long‐term prognosis remains unclear.
Cover Image, Volume 66, Issue 7
Authors: Di Bello Maria Pia , Mergola Lucia , Scorrano Sonia , Del Sole Roberta 
Published: June 2017

The cover image, by Maria Pia Di Bello et al., is based on the Research Article Towards a new strategy of a chitosan‐based molecularly imprinted membrane for removal of 4‐nitrophenol in real water samples, DOI: 10.1002/pi.5360.
image
Hill climbing hysteresis of perovskite‐based solar cells: a maximum power point tracking investigation
Authors: Pellet Norman , Giordano Fabrizio , Ibrahim Dar M. , Gregori Giuliano , Zakeeruddin Shaik Mohammed , Maier Joachim , Grätzel Michael 
Published: June 2017

AbstractThe surge of the power conversion efficiency of metal halide lead perovskite solar cells comes with concerns, such as the long‐term ecotoxicity of lead compounds, their sensitivity toward moisture and oxygen, or the scarcity of some of their components. Most perovskite solar cells still suffer from serious stability problems when measured under real working conditions (maximum power point tracking at 60°C). In the long run, stability will certainly decide on the fate of CH3NH3PbI3 and related lead perovskites for their use in photovoltaic modules. Herein, we show an effective and inexpensive strategy to perform ageing of perovskite solar cells under maximum power point tracking. For the first time, we analyze the issue of power extraction from solar cells exhibiting hysteresis. We show that a standard tracking algorithm such as perturb and observe fails to converge to the maximum power point of the solar cell if it exhibits j(V) hysteresis, and we present an effective strategy to stabilize the algorithm. We show that enforcing oscillations in forward bias can boost the mean power output of some perovskite solar cells by more than 10%, in contrast to a reference crystalline silicon solar cell. Copyright © 2017 John Wiley & Sons, Ltd.
A rapid and easy protein N‐terminal profiling strategy using (N‐Succinimidyloxycarbonylmethyl)tris(2,4,6‐trimethoxyphenyl)phosphonium bromide (TMPP) labeling and StageTip
Authors: Li Yanchang , Wang Zhiqiang , Zhou Wenjing , Zhang Kun , Ma Jie , Wu Feilin , Ji Jianguo , Hong Xuechuan , Deng Zixin , He Simin , Xu Ping 
Published: June 2017

Protein N‐terminal profiling is crucial when characterizing biological functions and provides proteomic evidences for genome reannotations. However, most of the current N‐terminal enrichment approaches involve multiple chemical derivatizations and chromatographic separation processes which are time consuming and can contribute to N‐terminal peptide losses. In this study, a fast, one‐step approach utilizing (N‐Succinimidyloxycarbonylmethyl)tris(2,4,6‐trimethoxyphenyl)phosphonium bromide (TMPP) derivatization and StageTip separation was developed to enhance N‐terminal peptide enrichment and analysis. Based on the characteristics of TMPP‐derivatized samples, such as a higher hydrophobicity and increased likelihood to produce a and b ions in collision‐induced dissociation or HCD fragmentation modes, first the SDS‐PAGE was optimized to increase protein loading and gel entry and to remove unbound TMPP. Then, this process was combined with a simplified StageTip separation and a new scoring criterion (considering a, b and y ions) to identify more TMPP‐modified N‐terminal spectra. When utilizing a low amount of starting material (∼20 μg protein), a total of 581 yeast N‐terminal peptides were identified, with 485 of them being TMPP modified, in only about one third of the general experimental time. It is hoped that the workflow constructed herein will provide a fast and practical strategy for N‐terminomic studies.
Informing System Design Using Human Performance Modeling
Authors: Watson Michael , Rusnock Christina , Miller Michael , Colombi John 
Published: June 2017

ABSTRACTHumans play a key role in the operation and support of most systems and model‐based systems engineering (MBSE) offers new opportunities to properly consider human capabilities and involvement. This research presents an approach for systems engineers to integrate system models with human performance modeling for early and more effective system design. Unlike analyses using traditional physics‐based models found in most extant MBSE literature, adjusting system parameters for human‐based analyses can greatly impact the design of the system itself. Adjusting a human‐system parameter can lead to design implications including adjustments to task allocation, process and workflow, and interface design. To demonstrate this, a quantitative case‐study approach is used. Starting with a set of Systems Modeling Language (SysML) diagrams, a task analysis is performed to inform an “as is” model of human performance in the Improved Performance Research Integration Tool (IMPRINT). An alternative IMPRINT model is created with varying design parameters and utilized to perform a trade study. Through the analysis, constraints and assumptions placed on the human are verified and the results of varying automation estimated. With current design emphasis in MBSE and model‐based engineering (MBE), there is great opportunity to emphasize human considerations and integrate human performance analysis.
Successful fertility‐sparing surgery and chemotherapy for stage IC3 ovarian cancer with the postoperative use of the traditional Japanese herbal formulation hachimijiogan: A case report
Authors: Nishio Eiji , Kawai Satoshi , Akita Eri , Fujii Takuma 
Published: June 2017

ABSTRACTCaseA 32‐year old, unmarried, nulligravida woman was diagnosed as having ovarian cancer stage IC3. The patient received six cycles of carboplatin and paclitaxel every 4 weeks after surgery. She was given a gonadotropin‐releasing hormone agonist as an ovarian safeguard while receiving treatment with anticancer agents.OutcomeAfter treatment with the traditional Japanese herbal formulation hachimijiogan and oral contraceptives, the patient spontaneously became pregnant and gave birth to a healthy baby at 40 gestational weeks.ConclusionA hachimijiogan treatment may be effective for treating decreased ovarian function following chemotherapy.
Postnatal outcome of fetal isolated ventricular size disproportion in the absence of aortic coarctation
Authors: van Nisselrooij A. E. L. , Rozendaal L. , Linskens I. H. , Clur S. A. , Hruda J. , Pajkrt E. , van Velzen C. L. , Blom N. A. , Haak M. C. 
Published: June 2017

ABSTRACTObjectiveCardiac ventricular size disproportion is a marker for aortic coarctation (CoA) in fetal life, but approximately 50% of fetuses do not have CoA after birth. The aim of this study was to evaluate the postnatal outcome of cases with fetal ventricular size disproportion in the absence of CoA after birth.MethodsAll cases with fetal isolated ventricular size disproportion diagnosed between 2002 and 2015 were extracted from a prenatal congenital heart defects regional registry. Cases were stratified according to presence or absence (non‐CoA) of aortic arch anomalies after birth. Postnatal outcome of non‐CoA cases was evaluated by assessing the presence of cardiac and other congenital malformations, genetic syndromes and other morbidity after birth. Non‐CoA cases were further classified according to whether they had cardiovascular pathology requiring medication or intervention.ResultsSeventy‐seven cases with fetal ventricular size disproportion were identified, of which 46 (60%) did not have CoA after birth. Of these, 35 did not require cardiovascular intervention or medication, whereas 11 did. Of the 46 non‐CoA cases, six presented with clinical pulmonary hypertension requiring treatment after birth, cardiac defects were present in 24 cases and syndromic features were seen in four. Overall, 43% of all non‐CoA children were still under surveillance at the end of the study period.ConclusionsThe postnatal course of cases with fetal ventricular size disproportion is complicated by prenatally undetected congenital defects (46%) and pulmonary or transition problems (35%) in a significant number of cases that do not develop CoA. Proper monitoring of these cases is therefore warranted and it is advisable to incorporate the risks for additional morbidity and neonatal complications in prenatal counseling. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Detecting deceptive engagement in social media by temporal pattern analysis of user behaviors: a survey
Authors: Xiao Qian , Bertino Elisa 
Published: June 2017

Deceptive engagement in social media, such as spamming, commenting, or rating with automatic scripts, spreading fabricated facts, seriously affects users’ trust on online services. Given the large volumes of information generated by users, effectively spotting users involved such deceptive engagement has become a challenging problem. Recent research has shown that techniques for analyzing temporal behavioral patterns are critical to address such problem. In this study, we survey recent advances in these techniques. We first summarize three approaches to model temporal information. Then, by using representative application examples, we discuss recent approaches with respect to their applications to real‐world large‐scale social media. With a focus on the temporal perspective, we then discuss advantages and challenges of each approach. WIREs Data Mining Knowl Discov 2017, 7:e1210. doi: 10.1002/widm.1210This article is categorized under:

Fundamental Concepts of Data and Knowledge > Knowledge Representation
Fundamental Concepts of Data and Knowledge > Motivation and Emergence of Data Mining
Technologies > Prediction
STARR with Contour Transtar for Obstructed Defecation Syndrome: Long‐Term Results
Authors: Mari Francesco Saverio , Pezzatini Massimo , Gasparrini Marcello , Antonio Brescia 
Published: June 2017

AbstractIntroductionObstructed defecation syndrome (ODS) is a widespread and disabling syndrome. With this study, we want to evaluate the long‐term results of stapled transanal rectal resection (STARR) performed with Contour Transtar device in the treatment for ODS. A re‐evaluation of 113 patients subjected to STARR from June 2007 to January 2010 was conducted.MethodsAll the patients treated for symptomatic ODS with STARR with Contour Transtar were included in the study. We re‐evaluate all patients treated in the study period with clinical examination and specific questionnaire to verify the stability of the functional results and the satisfaction at 5 years from surgery. Constipation was graded using the Agachan–Wexner constipation score; eventual use of aids to defecate and patient satisfaction were assessed preoperatively, 6 months and 5 years after surgery. Long‐term complications were also investigated.ResultsConstipation intensity decreased from the preoperative value of 15.8 (±4.9) to 5.2 (±3.9) (p < 0.0001) at 6 months and remained stable after 5 years (7.4 ± 4.1; p < 0.01). Patients who use laxatives and enema decrease from 74 (77%) and 27 (28%) to only 16 (17%; p < 0.001) and 5 (5%; p < 0.001), respectively, at 5‐year follow‐up. None continue to help themselves with digitations after surgery. Also the satisfaction rate remained stable (3.64 vs 3.81) during the 5 years of the study.ConclusionThe long‐term results have demonstrated the efficacy of the STARR with Contour Transtar in treating ODS and the stability over time of the defecatory improvements.Clinical trial registrationClinicaltrials.gov NCT02971332.
New eco-friendly low-cost binders for Li-ion anodes
Authors: Versaci D. , Nasi R. , Zubair U. , Amici J. , Sgroi M. , Dumitrescu M. A. , Francia C. , Bodoardo S. , Penazzi N. 
Published: June 2017

Abstract
In the production of commercial Li-ion batteries, the active materials slurries are generally prepared using polyvinylidene fluoride (PVdF) as binder because of its good adhesion properties and electrochemical stability. Unfortunately, there are some disadvantages related to the use of PVdF: the most important is the use of toxic and environmentally unfriendly solvents, such as N-methyl-pyrrolidone (NMP), and the second is the high costs. In the light of these considerations, it seemed straightforward to investigate the suitability of some water-soluble, inexpensive, and eco-friendly materials to test as alternative binders (sodium alginate, chitosan tragacanth gum, gelatin). The rheological properties of these materials have been investigated in addition to the electrochemical characterization. Furthermore, graphite electrodes with PVdF, carboxymethyl cellulose (CMC), and styrene-butadiene rubber (SBR) binders have been considered for sake of comparison. We found that some of these water-soluble binders, besides good electrochemical performances, showed a high adhesion to the current collector and a good electrochemical stability under the experimental conditions employed, which makes them interesting for the next generation of Li-ion batteries.
Modern Freshwater Reservoir Offsets in the Eurasian Steppe: Implications for Archaeology
Authors: Svyatko Svetlana V , Reimer Paula J , Schulting Rick 
Published: June 2017

AbstractThis paper presents the results of the first broad-scale study of modern freshwater reservoir effects (FREs) in various regions of the Eurasian Steppe, associated with archaeological sites. The aim of this work was not only to demonstrate the widespread variability of modern FREs in the region, but also to draw the attention of specialists working in the area to the necessity of taking into account this important and still not fully understood factor involving radiocarbon dating of human and some faunal remains from archaeological sites. To identify modern FREs, modern fish of different species from 10 regions of Siberia and Kazakhstan have been subjected to accelerator mass spectrometry radiocarbon (AMS 14C) dating and stable carbon and nitrogen isotope analysis, and the results are compared with the existing data from previous research. Freshwater reservoir offsets have been detected in all analyzed regions, with the exception of Kharga Lake (Buryatia, Russia) and Kyzylkoi River (central Kazakhstan), varying not only between, but also within regions depending on fish species. The most significant offset in this study has been recorded for the Chuya River basin (Altai Mountains, 1097±40 14C yr), though not as high as observed in previous research for the Caspian lowlands (1477±52 and 1037±52 14C yr) and Upper Lena River basin (Lake Baikal area, 1981±30 14C yr). Both δ13C and δ15N values have been measured with the majority of samples reflecting C3 ecology of local reservoirs and δ15N depending on the diet of particular species, with predatory species such as pike, perch, and burbot demonstrating the highest δ15N. No general relationship has been observed between freshwater reservoir offsets and either δ13C or δ15N values of the samples.
Evaluation of the impact of 2 years of a dosing intervention on canine echinococcosis in the Alay Valley, Kyrgyzstan
Authors: VAN KESTEREN F. , MASTIN A. , TORGERSON P. R. , MYTYNOVA BERMET , CRAIG P. S. 
Published: June 2017

SUMMARYEchinococcosis is a re-emerging zoonotic disease in Kyrgyzstan. In 2012, an echinococcosis control scheme was started that included dosing owned dogs in the Alay Valley, Kyrgyzstan with praziquantel. Control programmes require large investments of money and resources; as such it is important to evaluate how well these are meeting their targets. However, problems associated with echinococcosis control schemes include remoteness and semi-nomadic customs of affected communities, and lack of resources. These same problems apply to control scheme evaluations, and quick and easy assessment tools are highly desirable. Lot quality assurance sampling was used to assess the impact of approximately 2 years of echinococcosis control in the Alay valley. A pre-intervention coproELISA prevalence was established, and a 75% threshold for dosing compliance was set based on previous studies. Ten communities were visited in 2013 and 2014, with 18–21 dogs sampled per community, and questionnaires administered to dog owners. After 21 months of control efforts, 8/10 communities showed evidence of reaching the 75% praziquantel dosing target, although only 3/10 showed evidence of a reduction in coproELISA prevalence. This is understandable, since years of sustained control are required to effectively control echinococcosis, and efforts in the Alay valley should be and are being continued.
Surges of advanced medical support associated with influenza outbreaks
Authors: KING J. C. , SCHWEINLE J. E. , HATCHETT R. J. , GAO Y. , LICHENSTEIN R. , ZHOU J. 
Published: June 2017

SUMMARYWe utilized de-identified data to evaluate increases in four outcomes during influenza outbreak periods (IOPs) including: hospitalization, intensive care unit admission, mechanical ventilation or death for adults aged 18 years or older with medically attended acute respiratory illnesses (MAARI) admitted to any of Maryland's 50 acute-care hospitals over 12 years. Weekly numbers of positive influenza tests in the Maryland area were obtained from the US Center for Disease Control and Prevention interactive website. The fewest consecutive weeks around the peak week containing at least 85% of the positive tests defined the IOP. Weekly counts of individual study outcomes were positively correlated with regional weekly counts of positive influenza tests during all the IOPs over 12 years. Also, rate ratios comparing daily occurrences of each study outcome between the IOP and non-IOP were significantly elevated. These results confirm conclusions of previous studies that influenza outbreaks are clearly associated with deaths and increased use of advanced medical resources by patients with MAARI. These data analyses suggest that increased efforts to develop more effective influenza vaccines and therapeutics should be a priority.
Is the medical treatment for arterial hypertension after primary aortic coarctation repair related to age at surgery? A retrospective cohort study
Authors: Lillitos Peter J , Nassar Mohamed S. , Tibby Shane M , Simmonds Joy , Salih Caner , Austin Conal , Anderson David , Krasemann Thomas 
Published: June 2017

AbstractBackgroundHypertension following primary coarctation repair affects up to a third of subjects. A number of studies suggest that future hypertension risk is reduced if primary repair is performed at a younger age.ObjectivesThe objective of this study was to evaluate the risk of future medical treatment for hypertension depending on age of primary coarctation repair.MethodsThis study was carried out at a tertiary paediatric cardiology referral centre. Retrospective database evaluation of children aged <16 years undergoing primary surgical coarctation repair between October, 2005 and October, 2014 was carried out. Patients with complex heart diseases were excluded. The following age groups were considered: neonate (⩽28 days), infant (>28 days and ⩽12 months), and children (>12 months). Main outcome measure is the need for long-term anti-hypertensive medication. The risk for re-coarctation was also evaluated.ResultsA total of 87 patients were analysed: 60 neonates, 17 infants, 10 children. Among them, 6.7% neonates, 29.4% infants, and 40% children required long-term anti-hypertensive medications. Group differences were statistically significant (p=0.004). After adjustment for type of repair, the risk of long-term anti-hypertensive therapy was 4.5 (95% confidence interval 1.2–16.9, p=0.025) and 10.5 times (95% confidence interval 2.6–42.3, p=0.001) higher if primary repair was carried out in infancy and childhood, respectively, compared with neonates. Among all, 13 patients developed re-coarctation: 21.7% in the neonatal group, 5.9% in the infant group, and 20% in the child group. We could not demonstrate a significant difference between these proportions or calculate a reliable risk for developing re-coarctation.ConclusionsRisk of medical treatment for hypertension was lowest when primary repair was carried out during the neonatal period, rising 10-fold if first operated on as a child. Knowing the likelihood of hypertension development depending on age of primary repair is useful for long-term surveillance and counselling.
Dental students’ concerns regarding OSPE and OSCE: a qualitative feedback for process improvement
Authors: Shahzad Ambreen , Saeed M Humza Bin , Paiker Sadia 
Published: June 2017

Abstract
Objectives:
Objective structured practical examination (OSPE) and objective structured clinical examination (OSCE) have become established as reliable, valid and objective methods of assessing practical and clinical skills in dental schools. This study explored the perceptions of dental undergraduates' regarding OSPE and OSCE.

Design and Setting:
Two focus groups were made; the first consisted of students who had recently undergone an OSPE, while the other group was of fresh graduates (FG) who had given an OSCE in the final examination. A trained facilitator conducted the discussion-based interview for each focus group. Both discussions were recorded via audio recorders and transcribed verbatim. The data were thereafter analysed thematically.

Results:
Findings from the study suggested that the students and FGs were generally satisfied with the OSPE and OSCE. However, they perceived that the time allocated to the stations was not well balanced, nor were the examiners trained to conduct the examination. More importantly, the FGs opined that practical skills were not adequately tested on the OSCE, and thus the curricular content was not adequately covered.

Conclusion:
The study highlights issues that may arise while conducting the OSPE and OSCE, thus informing future guidelines for conducting OSPE and OSCE.