bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel, simple and rapid route to the synthesis of boron cabonitride nanosheets: combustive gaseous unfolding
Authors: Jalaly Maisam , José Gotor Francisco , Semnan Masih , Jesús Sayagués María 
Published: June 2017

AbstractThe ternary compound boron carbonitride (BCN) was synthesized in the form of few-layer nanosheets through a mechanically induced self-sustaining reaction (MSR). Magnesium was used to reduce boron trioxide in the presence of melamine in a combustive manner. The process to form the nanostructured material was very rapid (less than 40 min). The prepared powder was investigated by various techniques such as X-ray diffraction (XRD), Fourier Transform infrared (FTIR), Micro-Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), high-resolution transmission electron microscopy (HRTEM), and electron energy loss spectroscopy (EELS). The thermal stability and the optical behavior of the BCN nanosheets were also studied by thermal analysis and UV-vis spectroscopy, respectively. The formation mechanism of the nanosheet morphology was described in detail.
Genome-wide analyses of SWEET family proteins reveal involvement in fruit development and abiotic/biotic stress responses in banana
Authors: Miao Hongxia , Sun Peiguang , Liu Qing , Miao Yulu , Liu Juhua , Zhang Kaixing , Hu Wei , Zhang Jianbin , Wang Jingyi , Wang Zhuo , Jia Caihong , Xu Biyu , Jin Zhiqiang 
Published: June 2017

AbstractSugars Will Eventually be Exported Transporters (SWEET) are a novel type of sugar transporter that plays crucial roles in multiple biological processes. From banana, for the first time, 25 SWEET genes which could be classified into four subfamilies were identified. Majority of MaSWEETs in each subfamily shared similar gene structures and conserved motifs. Comprehensive transcriptomic analysis of two banana genotypes revealed differential expression patterns of MaSWEETs in different tissues, at various stages of fruit development and ripening, and in response to abiotic and biotic stresses. More than 80% MaSWEETs were highly expressed in BaXi Jiao (BX, Musa acuminata AAA group, cv. Cavendish), in sharp contrast to Fen Jiao (FJ, M. acuminata AAB group) when pseudostem was first emerged. However, MaSWEETs in FJ showed elevated expression under cold, drought, salt, and fungal disease stresses, but not in BX. Interaction networks and co-expression assays further revealed that MaSWEET-mediated networks participate in fruit development signaling and abiotic/biotic stresses, which was strongly activated during early stage of fruit development in BX. This study provides new insights into the complex transcriptional regulation of SWEETs, as well as numerous candidate genes that promote early sugar transport to improve fruit quality and enhance stress resistance in banana.
Masked Visual Analysis: Minimizing Type I Error in Visually Guided Single-Case Design for Communication Disorders
Authors: Byun Tara McAllister , Hitchcock Elaine R. , Ferron John 
Published: June 2017

Purpose
Single-case experimental designs are widely used to study interventions for communication disorders. Traditionally, single-case experiments follow a response-guided approach, where design decisions during the study are based on participants' observed patterns of behavior. However, this approach has been criticized for its high rate of Type I error. In masked visual analysis (MVA), response-guided decisions are made by a researcher who is blinded to participants' identities and treatment assignments. MVA also makes it possible to conduct a hypothesis test assessing the significance of treatment effects.

Method
This tutorial describes the principles of MVA, including both how experiments can be set up and how results can be used for hypothesis testing. We then report a case study showing how MVA was deployed in a multiple-baseline across-subjects study investigating treatment for residual errors affecting rhotics. Strengths and weaknesses of MVA are discussed.

Conclusions
Given their important role in the evidence base that informs clinical decision making, it is critical for single-case experimental studies to be conducted in a way that allows researchers to draw valid inferences. As a method that can increase the rigor of single-case studies while preserving the benefits of a response-guided approach, MVA warrants expanded attention from researchers in communication disorders.
Applying a potential difference to minimise damage to carbon fibres
during carbon nanotube grafting by chemical vapour deposition
Authors: Anthony David B , Qian Hui , Clancy Adam J , Greenhalgh Emile S , Bismarck Alexander , Shaffer Milo S P 
Published: June 2017

Abstract
The application of an in situ potential difference between
carbon fibres and a graphite foil counter electrode (300 V, generating an
electric field ca 0.3–0.7 V μm−1),
during the chemical vapour deposition synthesis of carbon nanotube (CNT) grafted
carbon fibres, significantly improves the uniformity of growth without reducing
the tensile properties of the underlying carbon fibres. Grafted CNTs with
diameters 55 nm ± 36 nm and lengths around 10 μm
were well attached to the carbon fibre surface, and were grown without the
requirement for protective barrier coatings. The grafted CNTs increased the
surface area to 185 m2 g−1 compared to the
as-received sized carbon fibre 0.24 m2 g−1. The
approach is not restricted to batch systems and has the potential to improve CNT
grafted carbon fibre production for continuous processing.
Patterns of Opioid Prescription and Use After Cesarean Delivery
Authors: Bateman Brian T. , Cole Naida M. , Maeda Ayumi , Burns Sara M. , Houle Timothy T. , Huybrechts Krista F. , Clancy Caitlin R. , Hopp Stephanie B. , Ecker Jeffrey L. , Ende Holly , Grewe Kasey , Raposo Corradini Beatriz , Schoenfeld Robert E. , Sankar Keerthana , Day Lori J. , Harris Lynnette , Booth Jessica L. , Flood Pamela , Bauer Melissa E. , Tsen Lawrence C. , Landau Ruth , Leffert Lisa R. 
Published: June 2017

OBJECTIVE:
To define the amount of opioid analgesics prescribed and consumed after discharge after cesarean delivery.

METHODS:
We conducted a survey at six academic medical centers in the United States from September 2014 to March 2016. Women who had undergone a cesarean delivery were contacted by phone 2 weeks after discharge and participated in a structured interview about the opioid prescription they received on discharge and their oral opioid intake while at home.

RESULTS:
A total of 720 women were enrolled; of these, 615 (85.4%) filled an opioid prescription. The median number of dispensed opioid tablets was 40 (interquartile range 30–40), the median number consumed was 20 (interquartile range 8–30), and leftover was 15 (interquartile range 3–26). Of those with leftover opioids, 95.3% had not disposed of the excess medication at the time of the interview. There was an association between a larger number of tablets dispensed and the number consumed independent of patient characteristics. The amount of opioids dispensed did not correlate with patient satisfaction, pain control, or the need to refill the opioid prescription.

CONCLUSION:
The amount of opioid prescribed after cesarean delivery generally exceeds the amount consumed by a significant margin, leading to substantial amounts of leftover opioid medication. Lower opioid prescription correlates with lower consumption without a concomitant increase in pain scores or satisfaction.
A Shared Decision-Making Intervention to Guide Opioid Prescribing After Cesarean Delivery
Authors: Prabhu Malavika , McQuaid-Hanson Emily , Hopp Stephanie , Burns Sara M. , Leffert Lisa R. , Landau Ruth , Lauffenburger Julie C. , Choudhry Niteesh K. , Kaimal Anjali , Bateman Brian T. 
Published: June 2017

OBJECTIVE:
To assess whether a shared decision-making intervention decreases the quantity of oxycodone tablets prescribed after cesarean delivery.

TECHNIQUE:
A tablet computer-based decision aid formed the basis of a shared decision-making session to guide opioid prescribing after cesarean delivery. Women first received information on typical trajectories of pain resolution and expected opioid use after cesarean delivery and then chose the number of tablets of 5 mg oxycodone they would be prescribed up to the institutional standard prescription of 40 tablets.

EXPERIENCE:
From April 11, 2016, to June 10, 2016, 105 women were screened, 75 were eligible, and 51 consented to participate; one patient was excluded after enrollment as a result of prolonged hospitalization. The median number of tablets (5 mg oxycodone) women chose for their prescription was 20.0 (interquartile range 15.0–25.0), which was less than the standard 40-tablet prescription (P<.001).

CONCLUSION:
A shared decision-making approach to opioid prescribing after cesarean delivery was associated with approximately a 50% decrease in the number of opioids prescribed postoperatively in this cohort compared with our institutional standard prescription. This approach is a promising strategy to reduce the amount of leftover opioid medication after treatment of acute postcesarean pain.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, NCT02770612.
Bowel Dysfunction After Low Anterior Resection With Neoadjuvant Chemoradiotherapy or Chemotherapy Alone for Rectal Cancer: A Cross-Sectional Study from China
Authors: Qin Qiyuan , Huang Binjie , Cao Wuteng , Zhou Jie , Ma Tenghui , Zhou Zhiyang , Wang Jianping , Wang Lei 
Published: June 2017

BACKGROUND:Neoadjuvant therapy plays a vital role in the treatment of locally advanced rectal cancer but impairs bowel function after restorative surgery. Optimal decision making requires adequate information of functional outcomes.OBJECTIVE:This study aimed to assess postoperative bowel function and to identify predictors for severe dysfunction.DESIGN:The study included a cross-sectional cohort and retrospective assessments of pelvic anatomic features.SETTINGS:The study was conducted at a tertiary GI hospital in China.PATIENTS:Included patients underwent neoadjuvant chemoradiotherapy or chemotherapy without radiation and curative low anterior resection for rectal cancer between 2012 and 2014.MAIN OUTCOME MEASURES:Bowel function was assessed using the validated low anterior resection syndrome score. The thicknesses of the rectal wall, obturator internus, and levator ani were measured by preoperative MRI.RESULTS:A total of 151 eligible patients were identified, and 142 patients (94.0%) participated after a median of 19 months from surgery. Bowel dysfunction was observed in 71.1% (101/142) of patients, with 44.4% (63/142) reporting severe dysfunction. Symptoms of urgency and clustering were found to be major disturbances. Regression analysis identified preoperative long-course radiotherapy (p< 0.001) and a lower-third tumor (p= 0.002) independently associated with severe bowel dysfunction. Irradiated patients with a lower-third tumor (OR = 14.06;p< 0.001) or thickening of the rectal wall (OR = 11.09;p< 0.001) had a markedly increased risk of developing severe dysfunction.LIMITATIONS:The study was based on a limited cohort of patients and moderate follow-up after the primary surgery.CONCLUSIONS:Bowel function deteriorates frequently after low anterior resection for rectal cancer. Severe bowel dysfunction is significantly associated with preoperative long-course radiotherapy and a lower-third tumor, and the thickening of rectal wall after radiation is a strong predictor. Treatment decisions and patient consent should be implemented with raising awareness of bowel symptom burdens. SeeVideo Abstractat http://links.lww.com/DCR/A317.
Long-term Outcomes of Single-Site Laparoscopic Colectomy With Complete Mesocolic Excision for Colon Cancer: Comparison With Conventional Multiport Laparoscopic Colectomy Using Propensity Score Matching
Authors: Miyo Masaaki , Takemasa Ichiro , Ishihara Hiroyuki , Hata Taishi , Mizushima Tsunekazu , Ohno Yuko , Doki Yuichiro , Mori Masaki 
Published: June 2017

BACKGROUND:
Complete mesocolic excision has been suggested to improve oncological outcomes for patients with colon cancer. However, the long-term outcomes of single-site laparoscopic colectomy with complete mesocolic excision remain unclear.

OBJECTIVE:
We evaluated the long-term outcomes of single-site laparoscopic colectomy with complete mesocolic excision compared with conventional multiport laparoscopic colectomy for colon cancer, as well as the short-term outcomes.

DESIGN:
This is a single-center, retrospective study.

SETTINGS:
The study was conducted at Osaka University Hospital in Japan.

PATIENTS:
A total of 971 consecutive patients who underwent laparoscopic surgery for colon cancer between 2008 and 2014 were included. Of these patients, 517 were analyzed using propensity score matching (231 with single-site laparoscopic colectomy and 286 with conventional multiport laparoscopic colectomy).

MAIN OUTCOME MEASURES:
Recurrence, survival, intraoperative morbidity, and postoperative complications were analyzed.

RESULTS:
Before propensity score matching, the single-site laparoscopic colectomy group had greater proportions of women and of patients with right-sided and early stage tumors compared with the conventional multiport laparoscopic colectomy group. After matching, the 2 groups each included 200 patients and did not significantly differ in any patient characteristics. The median follow-up period was 41.4 months. The 2 groups showed similar rates of intraoperative morbidity (p = 0.22) and postoperative complications (p = 0.87). Rates of 3-year disease-free and overall survival in single-site laparoscopic colectomy and conventional, multiport, laparoscopic colectomy groups were 95.5% and 91.3% (p = 0.44) and 100.0% and 98.7% (p = 0.24). The 3-year disease-free and overall survival rates in each stage did not significantly differ between the 2 groups.

LIMITATIONS:
This study was limited by its retrospective nature.

CONCLUSIONS:
Single-site laparoscopic colectomy with complete mesocolic excision for colon cancer provided acceptable perioperative outcomes and oncological outcomes, similar to those achieved with conventional multiport laparoscopic colectomy. Evidence accumulation from randomized controlled trials will be necessary to promote the wide acceptance of single-site laparoscopic colectomy. See Video Abstract at http://links.lww.com/DCR/A326.
Tailored Treatment Strategy for Locally Advanced Rectal Carcinoma Based on the Tumor Response to Induction Chemotherapy: Preliminary Results of the French Phase II Multicenter GRECCAR4 Trial
Authors: Rouanet Philippe , Rullier Eric , Lelong Bernard , Maingon Philippe , Tuech Jean-Jacques , Pezet Denis , Castan Florence , Nougaret Stéphanie 
Published: June 2017

BACKGROUND:
Preoperative radiochemotherapy and total mesorectal excision are the standard-of-care for locally advanced rectal carcinoma, but some patients could be over- or undertreated.

OBJECTIVE:
This study aimed to assess the feasibility of radiochemotherapy tailored based on the tumor response to induction chemotherapy (FOLFIRINOX) to obtain a minimum R0 resection rate of 90% in the 4 arms of the study.

DESIGN:
This study is a multicenter randomized trial (NCT01333709).

SETTING:
This study was conducted at 16 French cancer specialty centers.

PATIENTS:
Two hundred six patients with locally advanced rectal carcinoma were enrolled between 2011 and 2014.

INTERVENTIONS:
Good responders (≥75% tumor volume reduction) were randomly assigned to immediate surgery (arm A) or standard radiochemotherapy (Cap 50: 50 Gy irradiation and 1600 mg/m2 oral capecitabine daily) plus surgery (arm B). Poor responders were randomly assigned to Cap 50 (arm C) or intensive radiochemotherapy (Cap 60, 60 Gy irradiation, arm D) before surgery.

OUTCOME MEASURES:
The primary end point was a R0 resection rate (circumferential resection margin >1 mm).

STATISTICAL CONSIDERATIONS:
The experimental strategies were to be considered effective if at least 28 successes (R0 resection) among 31 patients in each arm of stratum I and 34 successes among 40 patients in each arm of stratum II were reported (Simon 2-stage design).

RESULTS:
After induction treatment (good compliance), 194 patients were classified as good (n = 30, 15%) or poor (n = 164, 85%) responders who were included in arms A and B (16 and 14 patients) and arms C and D (113 and 51 patients). The trial was prematurely stopped because of low accrual in arms A and B and recruitment completion in arms C and D. Data from 133 randomly assigned patients were analyzed: 11, 19, 52, and 51 patients in arms A, B, C, and D. Good responders had smaller tumors than poor responders (23 cm3 vs 45 cm3; p < 0.001). The surgical procedure was similar among groups. The R0 resection rates [90% CI] were 100% [70–100], 100% [85–100], 83% [72–91], and 88% [77–95]. Among the first 40 patients, 34 successes were reported in arms C and D (85% R0 resection rate). The circumferential resection margin ≤1 rates were 0%, 0%, 12%, and 5% in arms A, B, C, and D. The rate of transformation from positive to negative circumferential resection margin was 93%.

LIMITATIONS:
There was low accrual in arms A and B.

CONCLUSION:
Tailoring preoperative radiochemotherapy based on the induction treatment response appears safe for poor responders and promising for good responders. Long-term clinical results are needed to confirm its efficacy. See Video Abstract at http://links.lww.com/DCR/A359.
The Effect of the Timing of Radiotherapy on Clinical and Patient-Reported Outcomes After Latissimus Dorsi Breast Reconstruction: A 10-Year Study
Authors: Peiris Lashan J. , Dawson Nicola C. , Laws Siobhan A. M. , Rainsbury Richard M. 
Published: June 2017

Background:
Breast reconstruction (BR) is considered to be adversely affected by radiotherapy (RT), particularly when an implant is used. The aim of this study was to compare clinical and patient-reported outcomes after expander-assisted latissimus dorsi breast reconstruction depending on the timing of RT.

Methods:
Patients undergoing BR over a 10-year period (follow-up mean, 56 [14–134] months) were divided into 3 groups. Group 1, RT after mastectomy and BR, Group 2, RT before mastectomy and BR, and Group 3, RT after mastectomy but before BR. The primary endpoints were early and late surgical interventions. Validated questionnaires were circulated to all study patients and matched controls.

Results:
Three hundred thirteen patients underwent 389 BRs. One hundred eighteen patients received RT, of which 65 had undergone expander-assisted latissimus dorsi breast reconstruction. Both use and timing of RT influenced clinical outcomes. Overall, use of RT resulted in a 3-fold increase in complications (P = 0.003). Postreconstruction RT resulted in more than double the number of complications compared with prereconstruction RT (P = 0.008) and delaying BR until after mastectomy and RT reduced complications to levels observed in control patients (P = nonsignificant). Complications were halved in patients undergoing autologous LD reconstruction (P = 0.0001). Patient-reported outcomes were similar for emotional well-being, satisfaction, and shoulder symptoms, although a nonsignificant increase in chronic breast symptoms was reported by the RT group.

Conclusion:
The timing and type of LD reconstruction chosen by patients receiving RT has a significant impact on the risk of subsequent complications and unplanned interventions but has little impact on longer term patient well-being or satisfaction.
RESIDUAL VITREOUS CORTEX AT THE FOVEA DURING VITRECTOMY FOR PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT REPAIR
Authors: Cho Eun Hyung , Ku Hee Chan , Il Won , Lee Eun Koo 
Published: June 2017

Purpose:
To investigate the frequency of residual cortex and the effectiveness of removal of residual cortex in the fovea during vitrectomy for primary rhegmatogenous retinal detachment repair.

Methods:
We retrospectively reviewed the charts and the operative videos of the 80 patients (80 eyes) who underwent vitrectomy for repair and who were observed for more than 6 months. After triamcinolone acetonide injection, we observed residual cortex on the surface of the retina. Residual cortex was removed with a diamond-dusted scraper. After surgery, we watched for the occurrence of epiretinal membrane (ERM) for at least 6 months. We graded ERM according to the postoperative visual acuity (thin membranes that did not affect vision vs. thick membranes that reduced vision).

Results:
Of the 80 eyes, 60 eyes (75%) showed macular residual cortex, which we removed with a scraper, and 20 eyes (25%) did not have visible cortical remnants. Postoperative ERM occurred in 30% of eyes (24/80). The rate of postoperative ERM was 35% (21/60) in eyes with residual cortex and 15% (3/20) in eyes without residual cortex (P = 0.091). In the 60 eyes with residual cortex during vitrectomy, a thin membrane occurred in 18 eyes (30%) and a thick membrane occurred in 3 eyes (5%). In the 20 eyes without residual cortex, however, a thin membrane occurred in 3 eyes (15%) and no thick membrane was found.

Conclusion:
Eyes with residual cortex have a higher rate of ERM than eyes with no residual cortex after vitrectomy for primary repair. It is uncertain whether removing the cortex reduces the rate of postoperative ERM. The residual cortex may have already started the pathogenesis of ERM, or surgical trauma may have played a role.
Ab Interno Trabeculectomy With a Dual Blade: Surgical Technique for Childhood Glaucoma
Authors: Khouri Albert S. , Wong Sze H. 
Published: June 2017

Purpose:
To introduce a technique using the Kahook Dual Blade for treatment of childhood glaucoma.

Patient and Method:
An infant developed glaucoma after cataract extraction and anterior vitrectomy. Ab interno trabeculectomy was performed in both eyes using a dual-blade device.

Results:
Description of technique to treat childhood glaucoma. Intraocular pressure reduced from 35 to 17 mm Hg in the right eye and from 52 to 18 mm Hg in the left eye after 7 to 10 weeks. There were no complications.

Conclusions:
This was a successful, minimally invasive procedure for treatment of childhood glaucoma.
Effect of Direct-to-Consumer Advertising on Statin Use in the United States
Authors: Chang Hsien-Yen , Murimi Irene , Daubresse Matthew , Qato Dima M. , Emery Sherry L. , Alexander G. Caleb 
Published: June 2017

Importance:
The value of direct-to-consumer advertising (DTCA) of prescription drugs is widely debated, as is the effect of DTCA on prescription sales and health care utilization.

Objective:
We examined the association between DTCA intensity for statin medications and prescription sales and cholesterol-related health care utilization.

Design, Setting, and Participants:
We conducted an ecological study for 75 designated market areas from 2005 to 2009 in the United States using linked data regarding televised DTCA volume, non-DTCA marketing and promotion, retail, mail order and long-term care prescription drug sales, prescription drug and ambulatory care health care utilization, and contextual factors such as health care density and socioeconomic status. Main outcomes and measures were volume of sales, number of dispensed prescriptions, and high cholesterol-related outpatient visits. Analyses were conducted in 2016.

Results:
The intensity of rosuvastatin and atorvastatin ad exposures per household varied substantially across designated market areas. After adjustment for socioeconomic, demographic, and clinical characteristics, each 100-unit increase in advertisement viewership was associated with a 2.22% [95% confidence interval (CI), 0.30%–4.19%] increase in statin sales. Similar patterns were observed between DTCA and statin dispensing among the commercially insured. DTCA was associated with increases in high cholesterol-related outpatient visits among adults 18–45 years of age (3.15% increase in visits per 100-unit increase in viewership, 95% CI, 0.98%–5.37%) but not among those 46–65 years of age (0.51%, 95% CI, −1.49% to 2.55%).

Conclusion:
DTCA for statins is associated with increases in statin utilization and hyperlipidemia-related outpatient visits, especially for young adults.