bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Systems Change in Early Implementation of Housing First in Canadian Communities: An Examination of Facilitators/Barriers, Training/Technical Assistance, and Points of Leverage
Authors: Worton S. Kathleen , Hasford Julian , Macnaughton Eric , Nelson Geoffrey , MacLeod Timothy , Tsemberis Sam , Stergiopoulos Vicky , Goering Paula , Aubry Tim , Distasio Jino , Richter Tim 
Published: December 2017

AbstractWe present interim findings of a cross‐site case study of an initiative to expand Housing First (HF) in Canada through training and technical assistance (TTA). HF is an evidence‐based practice designed to end chronic homelessness for consumers of mental health services. We draw upon concepts from implementation science and systems change theory to examine how early implementation occurs within a system. Case studies examining HF early implementation were conducted in six Canadian communities receiving HF TTA. The primary data are field notes gathered over 1.5 years and evaluations from site‐specific training events (k = 5, n = 302) and regional network training events (k = 4, n = 276). We report findings related to: (a) the facilitators of and barriers to early implementation, (b) the influence of TTA on early implementation, and (c) the “levers” used to facilitate broader systems change. Systems change theory enabled us to understand how various “levers” created opportunities for change within the communities, including establishing system boundaries, understanding how systems components can function as causes of or solutions to a problem, and assessing and changing systems interactions. We conclude by arguing that systems theory adds value to existing implementation science frameworks and can be helpful in future research on the implementation of evidence‐based practices such as HF which is a complex community intervention. Implications for community psychology are discussed.
Injury, illness, and disability risk in American seafarers
Authors: Lefkowitz Rafael Y. , Slade Martin D. , Redlich Carrie A. 
Published: December 2017

BackgroundSeafarers are an understudied and essential workforce, isolated from medical care. This study describes injuries, illness, and risk factors for resultant disability in one shipping company with a majority of American seafarers.MethodsThe study used a telemedicine database of injury and illness incidence in seafarers, and applied descriptive statistical methods and logistic regression modeling.ResultsIllnesses were more frequently reported than injuries (860 vs 479). The overall injury rate was 113 per 1000 person‐years, and the overall illness rate was 211 per 1000 person‐years. Seafarer ratings had higher risk for disability compared to officers (OR = 1.60; 95%CI 1.17, 2.18), and incidents on dry cargo ships (OR = 2.70; 95%CI 1.49, 4.91) and articulated tug‐barges (ATBs) (OR = 2.21; 95%CI 1.26, 3.86) had higher disability risk compared to container vessels.ConclusionAdditional research in this vital American workforce may be useful to confirm these findings forming a basis for preventive interventions.
Peripheral Templation‐Modulated Interconversion between an A4L6 Tetrahedral Anion Cage and A2L3 Triple Helicate with Guest Capture/Release
Authors: Bai Xuemin , Jia Chuandong , Zhao Yanxia , Yang Dong , Wang Shi‐Cheng , Li Anyang , Chan Yi‐Tsu , Wang Yao‐Yu , Yang Xiao‐Juan , Wu Biao 
Published: December 2017

AbstractAn anion‐coordination‐based A4L6 (“A” denotes anion and “L” is ligand) tetrahedral cage was constructed by a C2‐symmetric bis‐bis(urea) ligand and phosphate anion, which showed reversible interconversion with the A2L3 triple helicate as a response to the template, concentration, or solvent. Notably, an unusual “peripheral” templation was found to be critical to stabilize the tetrahedral structure. This peripheral effect was utilized to assemble an “empty” A4L6 cage that allows the multi‐stimuli‐controlled capture/release of biologically important species such as choline and acetylcholine.
Direct Annulation between Aryl Iodides and Epoxides through Palladium/Norbornene Cooperative Catalysis
Authors: Li Renhe , Dong Guangbin 
Published: December 2017

AbstractHerein we report a direct annulation between aryl iodides and epoxides through palladium/norbornene (Pd/NBE) cooperative catalysis. An iso‐propyl ester substituted NBE was found to be most efficient to suppress the formation of multiple‐NBE‐insertion byproducts and affords the desired 2,3‐dihydrobenzofuran derivatives in 44–99 % yields. The reaction is scalable and tolerates a range of functional groups. Asymmetric synthesis is realized using an enantiopure epoxide. Application of this method into a concise synthesis of insecticide fufenozide is demonstrated.
Separation of Linear and Branched Alkanes Using Host–Guest Complexation of Cyclic and Branched Alkane Vapors by Crystal State Pillar[6]arene
Authors: Ogoshi Tomoki , Saito Kazuki , Sueto Ryuta , Kojima Ryosuke , Hamada Yukie , Akine Shigehisa , Moeljadi Adhitya Mangala Putra , Hirao Hajime , Kakuta Takahiro , Yamagishi Tada‐aki 
Published: December 2017

AbstractActivated crystals of pillar[6]arene produced by removing the solvent upon heating were able to take up branched and cyclic alkane vapors as a consequence of their gate‐opening behavior. The uptake of branched and cyclic alkane vapors by the activated crystals of pillar[6]arene induced a crystal transformation to form one‐dimensional channel structures. However, the activated crystals of pillar[6]arene hardly took up linear alkane vapors because the cavity size of pillar[6]arene is too large to form stable complexes with linear alkanes. This shape‐selective uptake behavior of pillar[6]arene was further utilized for improving the research octane number of an alkane mixture of isooctane and n‐heptane: interestingly, the research octane number was dramatically improved from a low research octane number (17 %) to a high research octane number (>99 %) using the activated crystals of pillar[6]arene.
Novel strategy for molybdenum disulfide nanosheets grown on titanate nanotubes for enhancing the flame retardancy and smoke suppression of epoxy resin
Authors: Li Aijiao , Xu Wenzong , Wang Guisong , Wang Xiaoling 
Published: December 2017

ABSTRACTA novel hybrid consisting of a molybdenum disulfide (MoS2) coating on a titanium dioxide nanotube (TNT) surface (MoS2–TNT) was synthesized by a hydrothermal method. The MoS2, TNTs, and MoS2–TNT hybrid were incorporated into epoxy resin (EP) to study their effects on its thermal performance and flame retardancy. Thermogravimetric analysis results show that the char yield at 700 °C of EP–MoS2–TNTs was obviously increased compared with that of the EP–MoS2 or EP–TNTs; this indicated that MoS2–TNTs had a good carbonization effect. The limiting oxygen index, cone calorimetry, and smoke density tests showed that MoS2–TNTs effectively improved the flame retardancy and smoke suppression of EP. This was attributed to the physical barrier effect of MoS2 and the adsorption of TNTs. Moreover, the flame retardancy and smoke suppression of the EP–MoS2–TNTs were better than those of the EP–MoS2 or EP–TNTs alone with the same amount of addition; this indicated that there was a synergistic effect between MoS2 and TNTs. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46064.
The effect of mass transfer resistance and nonuniform initial solvent concentration on permeation through polymer membranes
Authors: Zielinski John M. , Alsoy Altinkaya Sacide 
Published: December 2017

ABSTRACTA numerical simulation model has been developed which enables one to examine the effects of surface mass transfer resistance on the evaluation of permeation (P*), diffusion (D), and solubility (S) coefficients from unsteady‐state mass transfer experiments as well as the transmission rate. A complementary analytical expression has been developed which validates the numerical model and facilitates the evaluation of the concentration dependence of P*, D, and S from sequential step‐change experiments, under experimental conditions when the surface mass transfer resistance can be neglected. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46126.
Zeolite filled siloxane composite foams: Compression property
Authors: Calabrese Luigi , Bonaccorsi Lucio , Bruzzaniti Paolo , Gullì Giuseppe , Freni Angelo , Proverbio Edoardo 
Published: December 2017

ABSTRACTIn this article, mechanical behavior under compression loads of an innovative adsorbent material, based on silicone composite foams filled with SAPO 34 zeolite, is presented. The innovative composite foams were obtained profiting by the dehydrogenative coupling of siloxane constituents. These new adsorbent systems have been proposed to overcome to the low mechanical stability of conventional SAPO‐34 coating for adsorption chiller. In this concern, static and cyclic compressive tests at room temperature have been carried out. Samples at increasing content of SAPO 34 zeolite were tested to evaluate the influence of the filler content on the mechanical behavior of the composite foam. The results showed that the presence of zeolite reduces the elastic limit of the foam and increases the strength. The foams evidenced also acceptable mechanical stability to cyclic compressive loads. The encouraging results confirm the possible use of these new composite foams as adsorbent materials for cyclic adsorption heat pumps. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46145.
Toward green three‐phase composites with enhanced dielectric permittivity
Authors: Zyane Adel , Brouillette François , Belfkira Ahmed , Lucas Romain , Marchet Pascal 
Published: December 2017

ABSTRACTThis work aims to investigate the dielectric potential of microcrystalline cellulose, a green biosourced material, as a third constituent in the three‐phase composites based on ethylene vinyl acetate‐vinyl ester of versatic acid (EVA‐VeoVa) terpolymer and BaTiO3. For that, new green three‐phase composites were prepared using an economic and green process, with simple implementation at room temperature and using water as a solvent. Compared with the binary composite EVA‐VeoVa/BaTiO3, the three‐phase composite EVA‐VeoVa/BaTiO3/microcrystalline cellulose showed an improvement of the BaTiO3 particles dispersion, enhanced relative permittivity, and reduced dielectric loss, which explains the significance of this study. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46147.
Synthesis and elastase inhibition activities of novel aryl, substituted aryl, and heteroaryl oxime ester derivatives
Authors: Hasdemir Belma , Sacan Ozlem , Yasa Hasniye , Kucuk Hatice B. , Yusufoglu Ayse S. , Yanardag Refiye 
Published: December 2017

AbstractFifteen novel aryl, substituted aryl and heteroaryl γ‐hydroxy‐ (2a–e), γ‐methoxyimino‐ (3a–e), and γ‐benzyloxyimino‐ (4a–e) butyric acid methyl esters were investigated for their enzyme inhibition, and the synthesis of 10 compounds (3a–e, 4a–e) is given in this study. The other five compounds (2a–e) were synthesized before in another study. Compounds 3a–e and 4a–e were synthesized in this work as original compounds and characterized by 1H and 13C NMR, IR, mass, and elemental analyses. Their (E/Z)‐isomerisation ratios were analyzed by 1H and 13C NMR. All of them are of pure (E)‐configuration. Due to the literature survey, the elastase inhibition activity was not studied for these compounds. Elastase inhibition ability was investigated in this work for five γ‐hydroxy‐ (2a–e), five γ‐methoxy‐ (3a–e), and five γ‐benzyloxyimino‐ (4a–e) butyric acid methyl esters. All these 15 compounds showed elastase inhibition activity. Compound 2b was the best one and exhibited a better activity than the standard ursolic acid whereas compound 2a worked like the standard. All these compounds can be novel elastase inhibitor agents in the pharmaceutical and cosmetic industries.
Impact and educational outcomes of a small group self‐directed teaching strategy in a clinical neuroscience curriculum
Authors: Nathaniel Thomas I. , Gainey Jordan C. , Williams Jessica A. , Stewart Bianca L. , Hood Michael C. , Brechtel Leanne E. , Faulkner Rakiya V. , Pendergrass Jasmine S. , Black Leigh‐Ann , Griffin Scott K. , Troup Christopher E. , Reuben Jayne S. , Black Asa C. 
Published: December 2017

The complexity of the material being taught in clinical neuroscience within the medical school curriculum requires creative pedagogies to teach medical students effectively. Many clinical teaching strategies have been developed and are well described to address these challenges. However, only a few have been evaluated to determine their impact on the performance of students studying clinical neuroscience. Interactive, 2‐hour, self‐directed small‐group interactive clinical case‐based learning sessions were conducted weekly for 4 weeks to integrate concepts learned in the corresponding didactic lectures. Students in the small groups analyzed cases of patients suffering from neurological disease that were based on eight learning objectives that allowed them to evaluate neuroanatomical data and clinical findings before presenting their case analysis to the larger group. Students’ performances on the formative quizzes and summative tests were compared to those of first‐year medical students in the previous year for whom the self‐directed, small‐group interactive clinical sessions were not available. There was a significant improvement in the summative performance of first‐year medical students with self‐directed clinical case learning in the second year (Y2) of teaching clinical neuroscience (P < 0.05) when compared with first‐year students in the first year (Y1) for whom the self‐directed learning approach was not available. Student performance in the formative assessments between Y1 and Y2 was not significantly different (P = 0.803). A target of ≥70% student scoring above 80% in the final summative examination was met. The current study revealed evidence for the impact and educational outcomes of a self‐directed, clinical teaching strategy in a clinical neuroscience curriculum for first‐year medical students. Anat Sci Educ 11: 478–487. © 2017 American Association of Anatomists.
Patterns of altered neural synchrony in the default mode network in autism spectrum disorder revealed with magnetoencephalography (MEG): Relationship to clinical symptomatology
Authors: Lajiness‐O'Neill Renée , Brennan Jonathan R. , Moran John E. , Richard Annette E. , Flores Ana‐Mercedes , Swick Casey , Goodcase Ryan , Andersen Tiffany , McFarlane Kaitlyn , Rusiniak Kenneth , Kovelman Ioulia , Wagley Neelima , Ugolini Maggie , Albright Jeremy , Bowyer Susan M 
Published: December 2017

Disrupted neural synchrony may be a primary electrophysiological abnormality in autism spectrum disorders (ASD), altering communication between discrete brain regions and contributing to abnormalities in patterns of connectivity within identified neural networks. Studies exploring brain dynamics to comprehensively characterize and link connectivity to large‐scale cortical networks and clinical symptoms are lagging considerably. Patterns of neural coherence within the Default Mode Network (DMN) and Salience Network (SN) during resting state were investigated in 12 children with ASD (MAge = 9.2) and 13 age and gender‐matched neurotypicals (NT) (MAge = 9.3) with magnetoencephalography. Coherence between 231 brain region pairs within four frequency bands (theta (4–7 Hz), alpha, (8–12 Hz), beta (13–30 Hz), and gamma (30–80 Hz)) was calculated. Relationships between neural coherence and social functioning were examined. ASD was characterized by lower synchronization across all frequencies, reaching clinical significance in the gamma band. Lower gamma synchrony between fronto‐temporo‐parietal regions was observed, partially consistent with diminished default mode network (DMN) connectivity. Lower gamma coherence in ASD was evident in cross‐hemispheric connections between: angular with inferior/middle frontal; middle temporal with middle/inferior frontal; and within right‐hemispheric connections between angular, middle temporal, and inferior/middle frontal cortices. Lower gamma coherence between left angular and left superior frontal, right inferior/middle frontal, and right precuneus and between right angular and inferior/middle frontal cortices was related to lower social/social‐communication functioning. Results suggest a pattern of lower gamma band coherence in a subset of regions within the DMN in ASD (angular and middle temporal cortical areas) related to lower social/social‐communicative functioning.Autism Res2018, 11: 434–449. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryCommunication between different areas of the brain was observed in children with ASD and neurotypical children while awake, but not working on a task. Magnetoencephalography was used to measure tiny magnetic fields naturally generated via brain activity. The brains of children with ASD showed less communication between areas that are important for social information processing compared to the brains of neurotypical children. The amount of communication between these areas was associated with social and social communication difficulties.
Rückbau von Spannbeton‐Talbrücken mit Vorschubgerüst
Authors: Däbritz Michael , Mertinaschk André 
Published: December 2017

AbstractDie mitteleuropäische Fernstraßeninfrastruktur der 1960er‐ und 1970er‐Jahre ist geprägt durch eine zunehmende Überbeanspruchung. Instandsetzungsmaßnahmen an diesen Bauwerken ermöglichen die weitere Nutzung häufig nur für einen begrenzten Zeitraum. Rückbau und Ersatzneubau erfordern insbesondere in ökologisch sensiblen Bereichen und solchen mit hoher Dichte an kreuzenden Verkehrswegen Sorgfalt bei der Auswahl eines Rückbausystems, welches zudem sicherstellt, dass Unterbrechungen des Verkehrs auf der betroffenen Strecke während der Baumaßnahmen auf ein Minimum beschränkt werden.Der Rückbau von Talbrücken mit Vorschubgerüst stellt einen geeigneten Lösungsansatz dar, welcher den Anforderungen an die Bauwerke und die Verkehrssicherheit gerecht wird. Der Artikel beschreibt Einsatzbedingungen für das Rückbauverfahren, die Funktionsweise und die Unterscheidung zum bekannten Neubau mit Vorschubgerüsten. Im Vergleich zu Neubauvorhaben muss im Grundsatz von höheren Belastungen ausgegangen werden, von einer Unschärfe zu erwartender Lasten aus dem Bestandsbauwerk und von zusätzlichen am Projekt beteiligten Gewerken wie dem Abbruchunternehmen. Anhand bisher durchgeführter Projekte werden Anforderungen an Planung, Montage und Robustheit der Konstruktion beschrieben sowie Schnittstellen zu anderen Projektbeteiligten berührt, die vor und während des Rückbauvorhabens in teilweise größerem Maße zu berücksichtigen sind als beim Neubau.
Engineering tunable biosensors for monitoring putrescine in Escherichia coli
Authors: Chen Xue‐Feng , Xia Xiao‐Xia , Lee Sang Yup , Qian Zhi‐Gang 
Published: December 2017

AbstractBiosensors can be a powerful tool for real‐time monitoring of specific small molecules and for precise control of gene expression in biological systems. Thus, biosensors have attracted much attention for monitoring increasing number of molecules. However, strategies to tune the properties of biosensors remain less explored, which might restrict their wide applicability. Here we report the development of tunable biosensors for monitoring putrescine, an important member of biological polyamines, in Escherichia coli. The native putrescine‐responsive PuuR repressor protein was employed as a sensing component, and its cognate operator was installed in engineered promoters to control the expression of downstream green fluorescent protein (GFP) mut3 as a reporter protein. The engineered biosensors were specific for putrescine, and the response time could be modulated by altering growth medium of the biosensor strains. In addition, the response dynamics and detection ranges of the biosensors can be tuned at the genetic level by modulation of PuuR expression, and by manipulation of the chromosomal genes involved in putrescine biosynthesis. To demonstrate utility of the biosensors, we were able to monitor the changes of endogenous putrescine levels caused by genetic manipulations. Furthermore, a link between the excretory putrescine titer and intracellular GFP fluorescence was established for an E. coli strain that was engineered for improved putrescine biosynthesis and excretion. This study provides a strategy for engineering synthetic biosensor circuit for monitoring and tuning the dynamics in sensing putrescine, which can be generally applicable for monitoring other chemicals through taking a similar approach in circuit design.
HPLC‐MS/MS analysis of anthocyanins in human plasma and urine using protein precipitation and dilute‐and‐shoot sample preparation methods, respectively
Authors: Liu Junguo , Song Jiuxue , Huang Karen , Michel Deborah , Fang Jim 
Published: December 2017

AbstractA high‐performance liquid chromatography tandem–mass spectrometry (HPLC‐MS/MS) method has been developed to analyze anthocyanins in urine and plasma to further understand their absorption, distribution, metabolism and excretion. The method employed a Synergi RP‐Max column (250 × 4.6 mm, 4 μm) and an API 4000 mass spectrometer. A gradient elution system consisted of mobile phase A (water–1% formic acid) and mobile phase B (acetonitrile) with a flow rate of 0.60 mL/min. The gradient was initiated at 5% B, increased to 21% B at 20 min, and then increased to 40% B at 35 min. The analysis of anthocyanins presents a challenge because of the poor stability of anthocyanins during sample preparation, especially during solvent evaporation. In this method, the degradation of anthocyanins was minimized using protein precipitation and dilute‐and‐shoot and sample preparation methods for plasma and urine, respectively. No interferences were observed from endogenous compounds. The method has been used to analyze anthocyanin concentrations in urine and plasma samples from volunteers administered saskatoon berries. Cyanidin‐3‐galactoside, cyanidin‐3‐glucoside, cyanidin‐3‐arabinoside, cyanidin‐3‐xyloside and quercetin‐3‐galactoside, the five major flavonoid components in saskatoon berries, were identified in plasma and urine samples.
Identification of anti‐inflammatory active ingredients from Tumuxiang by ultra‐performance liquid chromatography/quadrupole time‐of‐flight‐MSE
Authors: Gao Xia , Ma Yuling , Wang Zhuowei , Bia Ruibin , Zhang Pei , Hu Fangdi 
Published: December 2017

AbstractThe dried roots of Inula helenium L. (IH) and Inula racemosa Hook f. (IR) are used commonly as folk medicine as ‘tumuxiang’ (TMX). The mixing and sharing of IH and IR in clinical use is a universal phenomenon. Modern pharmacological studies confirmed that IH and IR display anti‐inflammatory activities. However, the difference in anti‐inflammatory pharmacodynamic substances between these two herbs is still unknown. In the present study, the fingerprints of 18 IH and nine IR samples were established using UPLC/QTOF‐MSE. A dimethylbenzene‐induced mouse ear vasodilation model was applied in evaluating the anti‐inflammatory properties of all 27 samples. Then, the spectrum–efficacy model between chemical characteristic peaks and anti‐inflammatory activities was investigated using principal component regression and partial least squares. Finally, the combination of UNIFI Scientific Information System with a library search of traditional Chinese medicines was employed to automatically characterize the peaks. UNIFI identified a total of 80 chemical components. Among the components, the 53 characteristic peaks showed correlation with anti‐inflammatory activities, pointing to phenolic and organic acids as primary anti‐inflammatory ingredients of TMX. This approach can efficiently and intelligently facilitate the identification of bioactive components from traditional Chinese medicine.