bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying the influence of global warming on unprecedented extreme climate events
Authors: Diffenbaugh Noah S. , Singh Deepti , Mankin Justin S. , Horton Daniel E. , Swain Daniel L. , Touma Danielle , Charland Allison , Liu Yunjie , Haugen Matz , Tsiang Michael , Rajaratnam Bala 
Published: April 2017

Significance
Extreme climate events have increased in many regions. Efforts to test the influence of global warming on individual events have also increased, raising the possibility of operational, real-time, single-event attribution. We apply four attribution metrics to four climate variables at each available point on a global grid. We find that historical global warming has increased the severity and probability of the hottest monthly and daily events at more than 80% of the observed area and has increased the probability of the driest and wettest events at approximately half of the observed area. Our results suggest that scientifically durable operational attribution is possible but they also highlight the importance of carefully diagnosing and testing the physical causes of individual events.
NIP1;2 is a plasma membrane-localized transporter mediating aluminum uptake, translocation, and tolerance inArabidopsis
Authors: Wang Yuqi , Li Ruihong , Li Demou , Jia Xiaomin , Zhou Dangwei , Li Jianyong , Lyi Sangbom M. , Hou Siyu , Huang Yulan , Kochian Leon V. , Liu Jiping 
Published: April 2017

SignificanceAluminum (Al) toxicity is a major constraint for crops grown on acid soils. Various plant species have adopted an Al exclusion/avoidance mechanism and/or internal tolerance mechanisms to ameliorate Al toxicity. InArabidopsis, the root organic acid exudation-based Al exclusion mechanism has been well characterized; however, no evidence for an internal Al tolerance mechanism has been reported. Here we identify NIP1;2 as an Al-malate transporter involved in Al removal from root cell walls and root-to-shoot Al translocation. We report that the NIP1;2-mediated Al-malate transport is dependent on Al-activated root malate efflux mediated by ALMT1 inArabidopsis. Taken together, our findings demonstrate the importance of the coordination between Al exclusion and internal Al detoxification mechanisms in Al tolerance inArabidopsis.
Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin
Authors: Liu Kang , Lin Fang-Tsyr , Graves Joshua D. , Lee Yu-Ju , Lin Weei-Chin 
Published: April 2017

Significance
Mutant form of p53 (mutp53) proteins are expressed at high levels in many human cancers and can promote tumor cell growth. However, their mechanisms of action have not been fully understood. Elucidation of the mechanisms may identify new therapeutic strategies for treating many cancers that contain mutp53s. We describe a role for several hotspot mutp53s in reducing the checkpoint response to replication stress through interacting with TopBP1. This finding provides a rationale for a synthetic lethality strategy to treat mutp53-harboring cancer cells with inhibitors of another ATR activator, DNA2. We also find that certain mutp53s directly promote DNA replication by bridging the interaction between TopBP1 and Treslin. These results uncover mechanisms by which mutp53 enhances DNA replication.
Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis
Authors: Rogers James A. , Mishra Manoj K. , Hahn Jennifer , Greene Catherine J. , Yates Robin M. , Metz Luanne M. , Yong V. Wee 
Published: April 2017

SignificanceGestational bisphenol-A exposure increases susceptibility to autoimmunity in a mouse model of multiple sclerosis; the disease manifested in adult male, but not female, mice when a suboptimal insult was applied. Bisphenol-A may be an environmental factor encountered during embryonic life that changes the immune system, leading to a lowered threshold for development of multiple sclerosis in later life.
Semibatch monomer addition as a general method to tune and enhance the mechanics of polymer networks via loop-defect control
Authors: Gu Yuwei , Kawamoto Ken , Zhong Mingjiang , Chen Mao , Hore Michael J. A. , Jordan Alex M. , Korley LaShanda T. J. , Olsen Bradley D. , Johnson Jeremiah A. 
Published: April 2017

SignificanceWe demonstrate that slow monomer addition during step-growth polymer network formation changes the fraction of loop defects within the network, thus providing materials with tunable and significantly improved mechanical properties. This phenomenon is general to a range of network-forming reactions and offers a powerful method for tuning the mechanics of materials without changing their composition.
Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia
Authors: Krabbe Grietje , Minami S. Sakura , Etchegaray Jon I. , Taneja Praveen , Djukic Biljana , Davalos Dimitrios , Le David , Lo Iris , Zhan Lihong , Reichert Meredith C. , Sayed Faten , Merlini Mario , Ward Michael E. , Perry David C. , Lee Suzee E. , Sias Ana , Parkhurst Christopher N. , Gan Wen-biao , Akassoglou Katerina , Miller Bruce L. , Farese Robert V. , Gan Li 
Published: April 2017

Significance
Frontotemporal dementia (FTD) is a disease characterized by degeneration of the frontal and/or temporal lobes of the brain. Symptoms of FTD include changes in personality, such as loss of social awareness and impulse control. A significant portion of inherited FTD cases are due to mutations in progranulin (PGRN). These mutations lead to a decrease in the production of PGRN. How lower levels of PGRN lead to FTD is unknown. Here, we show that humans carrying PGRN mutations and mice lacking PGRN display obsessive–compulsive disorders (OCDs). In mice, OCD behavior results partially from elevated levels of the cytokine TNFα and aberrant activation of immune cells of the brain known as microglia. Our findings provide evidence that targeting innate immune pathways could be a new therapeutic strategy to treat FTD.
Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate
Authors: Wu Wan-fu , Maneix Laure , Insunza Jose , Nalvarte Ivan , Antonson Per , Kere Juha , Yu Nancy Yiu-Lin , Tohonen Virpi , Katayama Shintaro , Einarsdottir Elisabet , Krjutskov Kaarel , Dai Yu-bing , Huang Bo , Su Wen , Warner Margaret , Gustafsson Jan-Åke 
Published: April 2017

SignificanceProstate cancer is an androgen receptor (AR)-dependent disease. Goals in treatment of prostate cancer include keeping low Gleason grades low and preventing development of the lethal disease castration-resistant metastatic prostate cancer. The present study revealed that ERβ modulates AR signaling by repressing AR driver RORc and increasing AR corepressor DACH1/2. Loss of ERβ resulted in up-regulation of genes whose expression is associated with poor prognosis in prostate cancer accompanied by down-regulation of tumor-suppressive or tumor-preventive genes. Treatment of mice with an ERβ agonist resulted in the nuclear import of PTEN and repression of AR signaling. ERβ may be a promising target for treating early stage prostate cancer to prevent cancer progression.
Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins
Authors: Li Jianchao , He Yunyun , Weck Meredith L. , Lu Qing , Tyska Matthew J. , Zhang Mingjie 
Published: April 2017

Significance
MyTH4-FERM myosins (Myo7a, Myo7b, and Myo15a) regulate actin-bundle protrusion structures in various tissues, including brush border microvilli of intestines and stereocilia of inner ear hair cells. Mutations of the cargo binding MyTH4-FERM tandems of these myosins are frequently associated with human diseases, including hearing loss, vision defects, and digestive disorders, but with poorly understood mechanisms. In this work, we present the high-resolution crystal structure of Myo7b C-terminal MyTH4-FERM tandem (CMF) in complex with the USH1C PDZ3 domain. The structure, together with biochemical studies, indicates that binding to PDZ domain scaffold proteins is a general property of these myosins. The complex structure reported here also helps to explain why numerous mutations identified in Myo7a CMF can cause deafness and blindness in humans.
Morphotype of bacteroids in different legumes correlates with the number and type of symbiotic NCR peptides
Authors: Montiel Jesús , Downie J. Allan , Farkas Attila , Bihari Péter , Herczeg Róbert , Bálint Balázs , Mergaert Peter , Kereszt Attila , Kondorosi Éva 
Published: April 2017

Significance
The mutualistic association between legumes and rhizobia has ecological and agronomical relevance because of its contribution to the global nitrogen cycle by biological nitrogen fixation. Legumes from the Inverted Repeat Lacking Clade (IRLC) impose irreversible differentiation to their endosymbionts through nodule-specific cysteine-rich (NCR) peptides. This study indicates that NCR gene families evolved via different pathways in IRLC species, in which their size and composition directly impacted the morphotype of their bacterial partners. The positive correlation between the diversity of NCRs with their physiological effects on bacteria provides a better understanding of the multiple roles played by this large family in nodule functioning.
‘I’m a Scouser’
Authors: Fitzgerald Richard , Thornborrow Joanna 
Published: April 2017

Abstract
Despite the emergence of newer forms of web-based political engagement, radio phone-ins continue to have a significant role in the enactment of the democratic process, providing a live forum for direct encounters between members of the public and politicians, beyond the professional forms of mediated encounters between studio journalists and politicians. In this paper, drawing on data from the BBC’s 2015 phone-in Election Call, we use Membership Categorisation Analysis to examine the ways in which political engagement is configured within this forum in the run up to the UK General Election in 2015. In particular, we examine how callers and politicians engage in live political debate through transforming personal experiences into politicised social categories. What emerges most significantly here is that, whereas in previous Election Call series participants configured political categories through personal social identities, in 2015 there is a particular emphasis on callers’ geographical locations as political categories.
Highly efficient inverted organic light emitting diodes by inserting a zinc oxide/polyethyleneimine (ZnO:PEI) nano-composite interfacial layer
Authors: Kaçar Rifat , Mucur Selin Pıravadılı , Yıldız Fikret , Dabak Salih , Tekin Emine 
Published: April 2017

Abstract
The electrode/organic interface is one of the key factors in attaining superior device performance in organic electronics, and inserting a tailor-made layer can dramatically modify its properties. The use of nano-composite (NC) materials leads to many advantages by combining materials with the objective of obtaining a desirable combination of properties. In this context, zinc oxide/polyethyleneimine (ZnO:PEI) NC film was incorporated as an interfacial layer into inverted bottom-emission organic light emitting diodes (IBOLEDs) and fully optimized. For orange-red emissive MEH-PPV based IBOLEDs, a high power efficiency of 6.1 lm W−1 at a luminance of 1000 cd m−2 has been achieved. Notably, the external quantum efficiency (EQE) increased from 0.1 to 4.8% and the current efficiency (CE) increased from 0.2 to 8.7 cd A−1 with rise in luminance (L) from 1000 to above 10 000 cd m−2 levels when compared to that of pristine ZnO-based devices. An identical device architecture containing a ZnO:PEI NC layer has also been used to successfully fabricate green and blue emissive IBOLEDs. The significant enhancement in the inverted device performance, in terms of luminance and efficiency, is attributed to a good energy-level alignment between the cathode/organic interface which leads to effective carrier balance, resulting in efficient radiative-recombination.
Water treatment: Chitosan associated with electrochemical methods
Authors: Tamiasso-Martinhon Priscila , de Souza João Marques Teixeira , da Silva Silvia Maria Cruzeiro , Pessoa Fernando Luiz Pellegrini , Sousa Célia 
Published: April 2017

Abstract
Pollution of water bodies due to the presence of toxic metals and organic compounds, bring out a series of environmental problems of public, government and social character. In addition, water pollution, has become the target and source of concern in many industrial sectors. Therefore, it is essential to develop technologies for treatment and purification of water. Chitosan is a natural product derived from chitin, extracted mainly from the shells of crustaceans. It is a low cost, renewable and biodegradable biopolymer of great socioeconomic and environmental importance. The classic treatment of wastewater containing metals involves physical chemistry processes of precipitation, ion exchange and electrochemistry. Electrochemical technology has been presented as the most promising methods for treating wastewater polluted with metals, colloids, dyes or oil in water emulsions; besides being used in removing organic compounds. Alternative methods like adsorption with biosorbents have been investigated. The great advantage of this latter over other techniques is the low generation of residues, easy recovery of metals and the possibility of reuse of the adsorbent. This article aimed to carry out an exploratory study, of bibliographical nature, on the use of chitosan in electrochemical methods for water treatment.
Portraits by the Artists as Young Men: Proust, Valéry, Colour
Authors: Watt Adam 
Published: April 2017

Abstract

Marcel Proust and Paul Valéry have received very little comparative critical attention. My article undertakes the first comparative analysis of works written and published by Proust and Valéry just four years apart when both were in their early twenties: Valéry’s prose ‘Glose sur quelques peintures’ (1891), which focuses on portraits by Cristofano Allori and Francisco de Zurbarán, and Proust’s ‘Portraits de peintres’ (1895), verse poems in which he celebrates paintings by Albert Cuyp, Paulus Potter, Antoine Watteau, and Anthony Van Dyck. My focus will be on the role colour plays in these brief, intense texts that are structurally at odds with the much more expansive spaces of the authors’ later works —
À la recherche du temps perdu
(1913–27) and the
Cahiers
(compiled 1894–1945). How do Proust and Valéry use colour when transposing the visual medium of painting into text? Proust is above all a prose writer and Valéry made his name as a poet. Does Proust’s handling of colour in his poetic texts differ from the ways in which colour figures in
À la recherche
? How does Valéry’s use of colour in his prose ‘Glose’ relate to the chromatic features of his verse? By taking colour in works written about paintings as a common thread I aim to determine the similarities and divergences of Proust and Valéry during the years of their apprenticeship as writers.
Calculating the quality of public high-throughput sequencing data to obtain a suitable subset for reanalysis from the Sequence Read Archive
Authors: Ohta Tazro , Nakazato Takeru , Bono Hidemasa 
Published: April 2017

Abstract
It is important for public data repositories to promote the reuse of archived data. In the growing field of omics science, however, the increasing number of submissions of high-throughput sequencing (HTSeq) data to public repositories prevents users from choosing a suitable data set from among the large number of search results. Repository users need to be able to set a threshold to reduce the number of results to obtain a suitable subset of high-quality data for reanalysis. We calculated the quality of sequencing data archived in a public data repository, the Sequence Read Archive (SRA), by using the quality control software FastQC. We obtained quality values for 1 171 313 experiments, which can be used to evaluate the suitability of data for reuse. We also visualized the data distribution in SRA by integrating the quality information and metadata of experiments and samples. We provide quality information of all of the archived sequencing data, which enable users to obtain sufficient quality sequencing data for reanalyses. The calculated quality data are available to the public in various formats. Our data also provide an example of enhancing the reuse of public data by adding metadata to published research data by a third party.
Applications of network analysis to routinely collected health care data: a systematic review
Authors: Brunson Jason Cory , Laubenbacher Reinhard C 
Published: April 2017

Abstract

Objective
To survey network analyses of datasets collected in the course of routine operations in health care settings and identify driving questions, methods, needs, and potential for future research.

Materials and Methods
A search strategy was designed to find studies that applied network analysis to routinely collected health care datasets and was adapted to 3 bibliographic databases. The results were grouped according to a thematic analysis of their settings, objectives, data, and methods. Each group received a methodological synthesis.

Results
The search found 189 distinct studies reported before August 2016. We manually partitioned the sample into 4 groups, which investigated institutional exchange, physician collaboration, clinical co-occurrence, and workplace interaction networks. Several robust and ongoing research programs were discerned within (and sometimes across) the groups. Little interaction was observed between these programs, despite conceptual and methodological similarities.

Discussion
We use the literature sample to inform a discussion of good practice at this methodological interface, including the concordance of motivations, study design, data, and tools and the validation and standardization of techniques. We then highlight instances of positive feedback between methodological development and knowledge domains and assess the overall cohesion of the sample.
A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma
Authors: Cozzens Jeffrey W. , Lokaitis Barbara C. , Moore Brian E. , Amin Devin V. , Espinosa José A. , MacGregor Margaret , Michael Alex P. , Jones Breck A. 
Published: April 2017

Abstract

BACKGROUND: The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented. This drug has received regulatory approval in Europe but awaits approval in the United States.

OBJECTIVE: To identify the appropriate dose and toxicity or harms of 5-ALA used for enhanced intraoperative visualization of malignant brain tumors, reported from a single medical center in the United States.

METHODS: Prior to craniotomy for resection of a presumed high-grade glioma, individuals were given oral 5-ALA as part of a rapid dose-escalation scheme. At least 3 patients were selected for each dose level from 10 to 50 mg/kg in 10 mg/kg increments. Adverse events, intensity of tumor fluorescence, and results of biopsies in areas of tumor and the tumor bed under white light and deep blue light were recorded.

RESULTS: A total of 19 patients were studied in this phase 1 study. Serious adverse events were unrelated to the ingestion of 5-ALA. At the highest dose level studied (50 mg/kg), 2 out of 6 patients were observed to have transient dermatologic redness and peeling. These were grade 1 adverse events, which were not serious enough to be dose limiting. Patients at higher dose levels (>40 mg/kg) were more likely to have strong tumor fluorescence. There were no instances of false positive fluorescence.

CONCLUSION: The use of 5-ALA for brain tumor fluorescence is safe and effective to a dose of 50 mg/kg. Dose-limiting toxicity was not reached in this study.
Managing herpes zoster in older adults
Authors: Beuscher Linda , Reeves Geri , Harrell Debbie 
Published: April 2017

Abstract:
NPs must be aware of special prescribing considerations for medication safety when managing the care of older adults with herpes zoster. Age-related physiologic changes of the body impact the pharmacokinetics and pharmacodynamics of antiviral and pain medications and can lead to potential adverse events.
Noninvasive Ventilation in Acute Hypoxemic Nonhypercapnic Respiratory Failure: A Systematic Review and Meta-Analysis
Authors: Xu Xiu-Ping , Zhang Xin-Chang , Hu Shu-Ling , Xu Jing-Yuan , Xie Jian-Feng , Liu Song-Qiao , Liu Ling , Huang Ying-Zi , Guo Feng-Mei , Yang Yi , Qiu Hai-Bo 
Published: April 2017

Objective:
To evaluate the effectiveness of noninvasive ventilation in patients with acute hypoxemic nonhypercapnic respiratory failure unrelated to exacerbation of chronic obstructive pulmonary disease and cardiogenic pulmonary edema.

Data Sources:
PubMed, EMBASE, Cochrane library, Web of Science, and bibliographies of articles were retrieved inception until June 2016.

Study Selection:
Randomized controlled trials comparing application of noninvasive ventilation with standard oxygen therapy in adults with acute hypoxemic nonhypercapnic respiratory failure were included. Chronic obstructive pulmonary disease exacerbation and cardiogenic pulmonary edema patients were excluded. The primary outcome was intubation rate; ICU mortality and hospital mortality were secondary outcomes.

Data Extraction:
Demographic variables, noninvasive ventilation application, and outcomes were retrieved. Internal validity was assessed using the risk of bias tool. The strength of evidence was assessed using Grading of Recommendations Assessment, Development, and Evaluation methodology.

Data Synthesis:
Eleven studies (1,480 patients) met the inclusion criteria and were analyzed by using a random effects model. Compared with standard oxygen therapy, the pooled effect showed that noninvasive ventilation significantly reduced intubation rate with a summary risk ratio of 0.59 (95% CI, 0.44–0.79; p = 0.0004). Furthermore, hospital mortality was also significantly reduced (risk ratio, 0.46; 95% CI, 0.24–0.87; p = 0.02). Subgroup meta-analysis showed that the application of bilevel positive support ventilation (bilevel positive airway pressure) was associated with a reduction in ICU mortality (p = 0.007). Helmet noninvasive ventilation could reduce hospital mortality (p = 0.0004), whereas face/nasal mask noninvasive ventilation could not.

Conclusions:
Noninvasive ventilation decreased endotracheal intubation rates and hospital mortality in acute hypoxemia nonhypercapnic respiratory failure excluding chronic obstructive pulmonary disease exacerbation and cardiogenic pulmonary edema patients. There is no sufficient scientific evidence to recommend bilevel positive airway pressure or helmet due to the limited number of trials available. Large rigorous randomized trials are needed to answer these questions definitely.