bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arrive, survive and thrive: essential stages in the re-colonization and recovery of zooplankton in urban lakes in Sudbury, Canada
Authors: Yan Norman D. , Bailey John , McGeer James C. , Manca Marina M. , Keller Wendel (Bill) , Celis-Salgado Martha P. , Gunn John M. 
Published: May 2016

<p>The recovery of lakes from severe, historical acid and metal pollution requires that colonists of extirpated species arrive, survive and subsequently thrive. We employed 40 year records from weekly to monthly crustacean zooplankton samples from Middle and Clearwater lakes near Sudbury, Canada, to identify the main mechanistic bottlenecks in this recovery process. While both lakes now have circum-neutral pH, acidity decreased more rapidly in Middle Lake because of past liming interventions, while Clearwater Lake, being larger and supporting more housing, likely receives more zooplankton colonists than Middle Lake. Community richness increased much faster in Middle Lake than in Clearwater Lake, at 1.6 <em>vs</em> 0.9 species decade<sup>-1</sup>, respectively. Richness has recovered in Middle Lake, when assessed against a target of 9-16 species collection<sup>-1</sup> determined from regional reference lakes, but it has not yet recovered in Clearwater Lake. Species accumulation curves and a metric of annual persistence show that this difference is a product not of greater rates of species introduction into Middle Lake, but rather to their greater annual persistence once introduced. Greater annual persistence was associated with better habitat quality (<em>i.e</em>., lower acid and metal toxicity) in Middle Lake, particularly early in the record, and lower planktivore abundance, more recently. These results support a growing consensus that ecological recovery of zooplankton from acidification and metal pollution does not depend strongly on propagule introduction rates which are adequate, but rather on propagule persistence, in lake-rich, suburban landscapes such as those near Sudbury. </p>
Past, present and future of the fish community of Lake Orta (Italy), one of the world’s largest acidified lakes
Authors: Volta Pietro , Yan Norman D. , Gunn John M. 
Published: May 2016

<p>Since 1926, the fishes in Lake Orta, one of Italy’s deepest natural lakes, were heavily damaged by profundal hypoxia and acidification linked to oxidation of ammonia from industrial effluents and by industrial metal pollution. Of the original 28 fish species, only perch survived the lake’s contamination. Recently, the water quality of the lake has been largely restored by reductions in pollutant inputs, and a massive liming intervention. These interventions restored fish habitat, but it is unclear whether the recent fish reintroductions were successful, and the present status of the fish community is unknown. Here we reviewed the history of the Lake Orta fish assemblage. Using an extensive 2014 sampling campaign, we compared the present fish community to both its pre-pollution composition and to the assemblages of nearby un-polluted, but otherwise similar lakes, Lake Mergozzo and Lake Maggiore. While nearshore fish density now appears normal in lake Orta, the open water community remains impoverished both in numbers and in species. Epilimnetic and hypolimnetic benthic nets were dominated by perch and roach in all the three lakes, but the catch of pelagic nets differed among lakes. Perch (<em>Perca fluviatilis)</em>, rudd (<em>Scardinius erythrophthalmus)</em> and brown trout (<em>Salmo trutta</em>) dominated in Lake Orta while shad (<em>Alosa fallax lacustris</em>) and coregonids (<em>Coregonus</em> spp.) were dominant in the open waters of the other two lakes, but missing from Lake Orta. Many fully or partially migratory species, including marble trout (<em>Salmo trutta marmoratus)</em>, eel (<em>Anguilla Anguilla)</em> and barbel (<em>Barbus plebejus)</em> were also missing from Lake Orta, a consequence of their initial extirpation and blocked re-colonization routes along the River Strona. In comparison with both pre-pollution and contemporary reference data, the fish community of Lake Orta has not been rehabilitated. The recovery of the littoral community is complete, but cold water species such as burbot (<em>Lota lota), </em>Arctic charr (<em>Salvelinus alpinus)</em> and bullhead (<em>Cottus gobio)</em> are still lacking, as are the pelagic zooplanktivores European whitefish (<em>Coregonus lavaretus)</em> and shad, which dominate offshore communities in the reference lakes, as they did a century ago in Lake Orta. To propose priorities for fish community rehabilitation in Lake Orta, we categorized the conservation, ecological and fishing values of each missing fish species in the lake, and evaluated the cost and probability of success of the needed intervention for each species. This analysis indicated that rehabilitation of shad and European whitefish should receive highest priority.</p>
Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India
Authors: Pandey Avinash , Desai A. , Ostwal V. , Patil V. , Kulkarni A. , Kulkarni R. , Patil N. , Chaukar D. , Prabhash K. , Banavali Shripad D. 
Published: May 2016

Abstract
Background: Oral cavity cancer is the most common cancer among rural India. There is a paucity of data for outcomes of operable oral cavity cancer from rural India. Use of maintenance metronomic may delay or avoid relapse. Aim: To evaluate outcomes of operable oral cavity carcinoma and evaluate impact of maintenance metronomic chemotherapy. Objectives: To evaluate disease-free survival (DFS), overall survival (OS), and factors affecting the outcome in operable oral cavity cancer. Materials and Methods: Data of patients diagnosed with oral cavity cancer registered between May 2008 and May 2014 were retrieved. Only those patients with operable oral cavity cancer and upfront definitive surgery were included in the study. Demographic profile, stage, tobacco consumption, adjuvant therapy, and pattern of failure were collected. Kaplan-Meir survival analysis was used to determine DFS and OS. Log-rank test was used to evaluate factors affecting outcome. Results: Median follow-up is 24 months. Out of 335 patients, 225 (67%) had advanced operable cancer with 42/225 (18%) and 183/225 (82%) as Stages III and IVA, respectively. Buccal mucosa was the most common subsite (178/335, 53%) followed by tongue (63/335, 19%). Ninety-two percent patients were addicted to smokeless tobacco, whereas 27% were smokers. Median DFS is 13 months with 2 years relative DFS 32%. Median OS is 30 months, with 2 years OS of 54%. Metronomic adjuvant oral chemotherapy was given in 130/225 (58%); Stage III and IVA patients with median of 14 months (3-18 months). Use of metronomic chemotherapy improved DFS (8 vs. 14 months, P = 0.22) and OS (14 vs. 26 months, P = 0.04). Conclusion: Oral cavity cancer is a major health care problem in rural India. Presentation at advanced stage leads to suboptimal outcomes. Benefit of metronomic maintenance chemotherapy in locally advanced oral cavity needs to be further evaluated prospectively.
Weekly paclitaxel as metronomic palliative chemotherapy in small cell lung cancer
Authors: Noronha Vanita , Sahu Arvind , Patil Vijay M. , Joshi Amit , Ramaswamy Anant , Chandrasekharan Arun , Kadam Nandkumar , Prabhash Kumar 
Published: May 2016

Abstract
Background: Topotecan is the standard second line agent used in relapsed small cell lung cancer (SCLC). However, the erratic availability and the cost of the drug has been a prohibitive factor for its use in second-line setting in India. Paclitaxel has shown antitumor activity in heavily pretreated patients with SCLC. Hence, this audit was performed to study the efficacy of weekly paclitaxel as a form of metronomic therapy in the second-line setting in SCLC. Materials and Methods: Fifty-seven patients of relapsed SCLC who presented to the thoracic medical oncology unit of Tata Memorial Centre, Mumbai between January 2011 and December 2015 were selected for this analysis. Weekly paclitaxel at a dose of 80 mg/m 2 was administered until progression or development of intolerable side effects or patient refusal. Data regarding baseline demographics, previous treatment history, response rate, progression-free survival, overall survival (OS), and toxicity to weekly paclitaxel was extracted from a prospectively maintained database in the thoracic medical oncology unit and was analyzed using SPSS version 16 (IBM, New York, USA). Kaplan-Meier survival analysis was performed. Results: Median age of the cohort was 58 years (40-77 years). Etoposide with carboplatin was the regimen used in 40 patients (70.2%) whereas the remaining 17 patients received etoposide with cisplatin (29.8%). Eastern Cooperative Oncology Group performance status at relapse was 1 in 3 (5.3%), 2 in 49 (86.0%), and 3 in 5 (8.7%) patients. The response rate and clinical benefit rate were 9.1% (5 patients) and 52.7% (29 patients), respectively. Grade 3-4 toxicities were seen in 10.5% (6 patients). The median PFS was 145 days (95% confidence interval [CI]: 116.6-173.5 days) whereas the median OS was 168 days (95% CI: 112.5-223.5 days). Conclusion: Weekly paclitaxel as a second line agent in relapsed small cell cancer of the lung is a feasible and well-tolerated agent.
Long term results of comparison of concurrent low‑dose daily cisplatin versus the standard weekly cisplatin with six fractions per week radiotherapy in locally advanced head neck cancer
Authors: Gupta Pramod Kumar , Lal Punita , Bajpai Ranjeet , Goel Anshu , Yadav Rajan , Verma Mranalini , Kumar Shaleen 
Published: May 2016

Abstract
Aim and Objective: Weekly administration of cisplatin (cis-diamminedichloroplatinum [CDDP]) appears more feasible and substantially more popular than the 3 weekly schedules due to better compliance. Different concurrent cisplatin schedules have been attempted including a daily schedule. We did a comparison of two consecutive single arm studies, i.e., use of weekly cisplatin versus daily cisplatin when used with concurrently with a moderately accelerated radiotherapy (RT) schedule. Patients and Methods: Two prospective feasibility, safety and efficacy studies were carried out consecutively within the department. The weekly CDDP study was done from August 2003 to August 2005 and daily CDDP study was conducted from November 2005 to June 2007. Both studies included locally advanced stage III and IV squamous cell carcinoma of the head and neck region with RT dose of 70 Gy. Concurrent single-agent cisplatin was administered weekly (35 mg/m 2) in the first and daily (6 mg/m 2) in the second study. Results: Weekly cisplatin study had 68 and daily CDDP study had 52 patients. The median follow-up in the two studies was 93 and 63 months, respectively. Compliance in the two studies was comparable. Acute Grade III/IV mucositis and dysphagia were significantly higher in weekly cisplatin study. Late Grade II/III toxicities such as xerostomia, dysphagia, ototoxicity and nephrotoxicity were similar. The 5 years locoregional control was 18% and 25% and 5 years overall survival rate was 32% and 31% in weekly and daily cisplatin studies, respectively. Conclusions: Modest acceleration along with either "weekly" or "daily" cisplatin, whichever is possible in one′s setup, is do-able, provided due attention is paid to patient selection and supportive care.
Hip Fracture Types in Canadian Men and Women Change Differently with Age: A Population-Level Analysis
Authors: Crilly Richard G. , Kloseck Marita , Mequanint Selam 
Published: May 2016

Background We have previously reported a gender difference in the occurrence of hip fracture type with age in our local population. In the current report, we have explored this phenomenon in a Canadian population using five years of data from a national administrative database. We have compared community-dwelling and institutionalized individuals to determine if frailty is important and has a differential effect on the type of hip fracture experienced. Methods Hospitalization records from 2005 to 2009, in which the most responsible diagnosis, that is the diagnosis causing the admission to hospital, was a hip fracture, were obtained from the Discharge Abstract Database of the Canadian Institute for Health Information. Hip fracture type was identified using the Canadian Classification of Health Interventions and the International Classification of Diseases 10th Revision, Canada (ICD-10-CA). Hip fracture proportions were calculated for the study period and stratified by age group and sex. Results The relative proportion of intertrochanteric fractures in women rose from 35% in the youngest group (55–59 years) to 51% in the oldest group (84+ years; P < 0.0001). In men, the proportions remain relatively stable (47% and 44%, respectively). Community and institutionalized patients showed the same pattern. Conclusions The change in the proportion of the two hip fracture types that occur in women but not men may point to differences in the etiology and consequently the approaches to prevention for the two fracture types. Level of frailty did not seem to be important.
Skills for Interviewing Adolescent Patients: Sustainability of Structured Feedback in Undergraduate Education on Performance in Residency
Authors: Joukhadar Nadim , Bourget Genna , Manos Sarah , Mann Karen , Hatchette Jill , Blake Kim 
Published: May 2016

ABSTRACT

Effective adolescent (10 to 19 years) interviewing by physicians is an essential skill that many trainees can find challenging.Background

We assessed whether structured adolescent interviewing using standardized patients (SPs) and feedback in undergraduate medical education (UME) has a sustained effect on residents' skills.Objective

Postgraduate year (PGY) 1 residents conducted interviews with a SP adolescent–mother pair. The SPs independently scored each PGY-1 interview using the structured communication adolescent guide (SCAG). Unpaired t tests were conducted comparing “Total-Item” and “Global” scores of PGY-1s who received structured SP adolescent interviewing with feedback in UME (“structured training” group) to those who had not (“no structured training” group).Methods

PGY-1s in the structured training group (n = 23) received significantly higher mean Total-Item scores from both the SP adolescent (40.78 ± 7.04 and 32.41 ± 10.12, respectively; P = .001) and the SP mother (40.48 ± 7.90 and 33.34 ± 10.90, respectively; P = .01) than those without structured training (n = 29). Statistically significant results favoring PGY-1s with prior training were also seen with the SP adolescent and mother total Global SCAG scores.Results

Structured training in adolescent interviewing with SPs and feedback in UME appears to have a sustained effect on residents' adolescent interviewing skills. PGY-1s will interview adolescents and may benefit from structured adolescent SP interviewing with feedback, especially individuals who did not have this experience during their medical school training.Conclusions
Developing a Tool to Assess Placement of Central Venous Catheters in Pediatrics Patients
Authors: Fleming Geoffrey M. , Mink Richard B. , Hornik Christoph , Emke Amanda R. , Green Michael L. , Mason Katherine , Petrillo Toni , Schuette Jennifer , Tcharmtchi M. Hossein , Winkler Margaret , Turner David A. 
Published: May 2016

ABSTRACT

Pediatric critical care medicine requires the acquisition of procedural skills, but to date no criteria exist for assessing trainee competence in central venous catheter (CVC) insertion.Background

The goal of this study was to create and demonstrate validity evidence for a direct observation tool for assessing CVC insertion.Objective

Ten experts used the modified Delphi technique to create a 15-item direct observation tool to assess 5 scripted and filmed simulated scenarios of CVC placement. The scenarios were hosted on a dedicated website from March to May 2013, and respondents recruited by e-mail completed the observation tool in real time while watching the scenarios. The goal was to obtain 50 respondents and a total of 250 scenario ratings.Methods

A total of 49 pediatrics intensive care faculty physicians (6.3% of 780 potential subjects) responded and generated 188 scenario observations. Of these, 150 (79.8%) were recorded from participants who scored 4 or more on the 5 scenarios. The tool correctly identified the expected reference standard in 96.8% of assessments with an interrater agreement kappa (standard error) = 0.94 (0.07) and receiver operating characteristic = 0.97 (95% CI 0.94–0.99).Results

This direct observation assessment tool for central venous catheterization demonstrates excellent performance in identifying the reference standard with a high degree of interrater reliability. These assessments support a validity construct for a pediatric critical care medicine faculty member to assess a provider placing a CVC in a pediatrics patient.Conclusions
Mapping Direct Observations From Objective Structured Clinical Examinations to the Milestones Across Specialties
Authors: Baker-Genaw Kimberly , Kokas Maria S. , Ahsan Syed F. , Darnley-Fisch Deborah , Drake Sean , Goyal Nikhil , Inamdar Kedar , Moutzouros Vasilios , Prabhakar Deepak , Rolland Laurie , Sangha Roopina , Shreve Maria , Woodward Ann 
Published: May 2016

ABSTRACT

Little is known about residents' performance on the milestones at the institutional level. Our institution formed a work group to explore this using an institutional-level curriculum and residents' evaluation of the milestones.Background

We assessed whether beginner-level milestones for interpersonal and communication skills (ICS) related to observable behaviors in ICS-focused objective structured clinical examinations (OSCEs) for postgraduate year (PGY) 1 residents across specialties.Objective

The work group compared ICS subcompetencies across 12 programs to identify common beginner-level physician-patient communication milestones. The selected ICS milestone sets were compared for common language with the ICS-OSCE assessment tool—the Kalamazoo Essential Elements of Communication Checklist–Adapted (KEECC-A). To assess whether OSCE scores related to ICS milestone scores, all PGY-1 residents from programs that were part of Next Accreditation System Phase 1 were identified; their OSCE scores from July 2013 to June 2014 and ICS subcompetency scores from December 2014 were compared.Methods

The milestones for 10 specialties and the transitional year had at least 1 ICS subcompetency that related to physician-patient communication. The language of the ICS beginner-level milestones appears similar to behaviors outlined in the KEECC-A. All 60 residents with complete data received at least a beginner-level ICS subcompetency score and at least a satisfactory score on all 3 OSCEs.Results

The ICS-OSCE scores for PGY-1 residents appear to relate to beginner-level milestones for physician-patient communication across multiple specialties.Conclusions
Evaluation of three lidar scanning strategies for turbulence measurements
Authors: Newman Jennifer F. , Klein Petra M. , Wharton Sonia , Sathe Ameya , Bonin Timothy A. , Chilson Phillip B. , Muschinski Andreas 
Published: May 2016

Abstract. Several errors occur when a traditional Doppler beam swinging (DBS) or velocity–azimuth display (VAD) strategy is used to measure turbulence with a lidar. To mitigate some of these errors, a scanning strategy was recently developed which employs six beam positions to independently estimate the u, v, and w velocity variances and covariances. In order to assess the ability of these different scanning techniques to measure turbulence, a Halo scanning lidar, WindCube v2 pulsed lidar, and ZephIR continuous wave lidar were deployed at field sites in Oklahoma and Colorado with collocated sonic anemometers.Results indicate that the six-beam strategy mitigates some of the errors caused by VAD and DBS scans, but the strategy is strongly affected by errors in the variance measured at the different beam positions. The ZephIR and WindCube lidars overestimated horizontal variance values by over 60 % under unstable conditions as a result of variance contamination, where additional variance components contaminate the true value of the variance. A correction method was developed for the WindCube lidar that uses variance calculated from the vertical beam position to reduce variance contamination in the u and v variance components. The correction method reduced WindCube variance estimates by over 20 % at both the Oklahoma and Colorado sites under unstable conditions, when variance contamination is largest. This correction method can be easily applied to other lidars that contain a vertical beam position and is a promising method for accurately estimating turbulence with commercially available lidars.
Injury Surveillance with District Health Information System 2 (DHIS2)
Authors: Jayatilleke Achala U. , Ganewatta Megha , Amarakoon Pamod , Hewapathirana Roshan , Jayatilleke Achini 
Published: May 2016

Injuries are a major but neglected global public health problem. In 2001, World Health Organization (WHO) published injury surveillance guidelines emphasizing the importance of injury surveillance at country levels to cope with this grave problem. However there are no customizable generic injury surveillance systems which can be used in developing countries. Therefore we conducted this study to customize open source public health information system, District Health Information System 2 (DHIS2) for injury surveillance and pilot it in a resource constrained country, Sri Lanka.