bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a French version of the Sleep Condition Indicator: a clinical screening tool for insomnia disorder according to DSM‐5 criteria
Authors: Bayard Sophie , Lebrun Cindy , Maudarbocus Khaalid Hassan , Schellaert Vanessa , Joffre Alicia , Ferrante Esther , Le Louedec Marie , Cournoulat Alice , Gely‐Nargeot Marie‐Christine , Luik Annemarie I. 
Published: May 2017

SummaryInsomnia disorder is frequent in the population, yet there is no French screening instrument available that is based on the updated DSM‐5 criteria. We evaluated the validity and reliability of the French version of an insomnia screening instrument based on DSM‐5 criteria, the Sleep Condition Indicator, in a population‐based sample of adults. A total of 366 community‐dwelling participants completed a face‐to‐face clinical interview to determine insomnia disorder against DSM‐5 criteria and several questionnaires including the French Sleep Condition Indicator version. Three‐hundred and twenty‐nine participants completed the Sleep Condition Indicator again after 1 month. Statistical analyses were performed to determine the reliability, construct validity, divergent validity and temporal stability of the French translation of the Sleep Condition Indicator. In addition, an explanatory factor analysis was performed to assess the underlying structure. The internal consistency (α = 0.87) and temporal stability (r = 0.86, P < 0.001) of the French Sleep Condition Indicator were high. When using the previously defined cut‐off value of ≤ 16, the area under the receiver operating characteristic curve was 0.93 with a sensitivity of 95% and a specificity of 75%. Additionally, good construct and divergent validity were demonstrated. The factor analyses showed a two‐factor structure with a focus on sleep and daytime effects. The French version of the Sleep Condition Indicator demonstrates satisfactory psychometric properties while being a useful instrument in detecting cases of insomnia disorder, consistent with features of DSM‐5, in the general population.
Night‐to‐night variability of obstructive sleep apnea
Authors: Stöberl Anna S. , Schwarz Esther I. , Haile Sarah R. , Turnbull Christopher D. , Rossi Valentina A. , Stradling John R. , Kohler Malcolm 
Published: May 2017

SummaryOne night of a sleep study is the standard for diagnosis and exclusion of obstructive sleep apnea. Single testing requires high sensitivity of the test method and a stable disease of interest to warrant a low rate of false‐negative tests. Obstructive sleep apnea is diagnosed and graded by conventional thresholds of apneas and hypopneas per hour of sleep, and treatment is usually initiated in the presence of symptoms. The aim of this study was to assess night‐to‐night variability of obstructive sleep apnea to reassess the current practice. Seventy‐seven patients previously diagnosed with obstructive sleep apnea, randomised to continuous positive airway pressure withdrawal within four trials, performed nightly pulse‐oximetry over 2 weeks while off continuous positive airway pressure. The main outcome of interest was the coefficient of variation of the oxygen desaturation index marking night‐to‐night variability in obstructive sleep apnea. Obstructive sleep apnea was categorised according to conventional thresholds using oxygen desaturation index (no obstructive sleep apnea: <5 per h; mild: 5–15 per h; moderate: 15–30 per h; and severe: >30 per h). High night‐to‐night variability of obstructive sleep apnea was evidenced by a coefficient of variation of oxygen desaturation index of 31.1% (SD 16.5). Differences in oxygen desaturation index of >10 per h between nights were found in 84.4% and shifts in obstructive sleep apnea severity category in 77.9% of patients. The probability of missing moderate obstructive sleep apnea was up to 60%. Variability was higher in less severe obstructive sleep apnea. Obstructive sleep apnea shows a considerable night‐to‐night variability. Single‐night diagnostic sleep studies are prone to miscategorise obstructive sleep apnea if arbitrary thresholds are used. Thus, treatment decisions should be based less on the conventional derivatives from sleep studies, especially in patients with less severe obstructive sleep apnea. Clinical trial registration: www.controlled-trials.com (ISRCTN 93153804, ISRCTN 73047833) and www.clinicaltrials.gov (NCT01332175 & NCT02050425).
Non‐shivering thermogenesis as a mechanism to facilitate sustainable weight loss
Authors: Palmer B. F. , Clegg D. J. 
Published: May 2017

SummaryCurrently, there is a significant percentage of the population who are or will be classified as obese, necessitating novel strategies to facilitate sustainable weight loss. Reductions in basal metabolic rate occur in the face of weight loss and pose formidable barriers to individuals attempting to sustain meaningful weight reductions. Here, we discuss the mechanisms by which non‐shivering thermogenesis may provide insight into metabolic pathways that can become druggable targets to facilitate sustainable weight loss. Specifically, we highlight the fact that non‐shivering thermogenesis results in activation and expansion of brown and beige adipose tissues as well as activates pathways in skeletal muscle which increase metabolic flux and activity of muscle fibres through futile calcium cycling across the endoplasmic reticulum all facilitating an increase in metabolism. Finally, we highlight the fact there are sexual dimorphisms with respect to these metabolic processes in keeping with the National Institutes of Health mandate of treating sex as a biologic variable.
Seasonal variability of the parameters of the Ball–Berry model of stomatal conductance in maize (Zea mays L.) and sunflower (Helianthus annuus L.) under well‐watered and water‐stressed conditions
Authors: Miner Grace L. , Bauerle William L. 
Published: May 2017

AbstractThe Ball–Berry (BB) model of stomatal conductance (gs) is frequently coupled with a model of assimilation to estimate water and carbon exchanges in plant canopies. The empirical slope (m) and ‘residual’ gs (g0) parameters of the BB model influence transpiration estimates, but the time‐intensive nature of measurement limits species‐specific data on seasonal and stress responses. We measured m and g0 seasonally and under different water availability for maize and sunflower. The statistical method used to estimate parameters impacted values nominally when inter‐plant variability was low, but had substantial impact with larger inter‐plant variability. Values for maize (m = 4.53 ± 0.65; g0 = 0.017 ± 0.016 mol m−2 s−1) were 40% higher than other published values. In maize, we found no seasonal changes in m or g0, supporting the use of constant seasonal values, but water stress reduced both parameters. In sunflower, inter‐plant variability of m and g0 was large (m = 8.84 ± 3.77; g0 = 0.354 ± 0.226 mol m−2 s−1), presenting a challenge to clear interpretation of seasonal and water stress responses – m values were stable seasonally, even as g0 values trended downward, and m values trended downward with water stress while g0 values declined substantially.
Chemical and physical characteristics of carrageenan extracted from Eucheuma spinosum harvested from three different Indonesian coastal sea regions
Authors: Diharmi Andarini , Fardiaz Dedi , Andarwulan Nuri , Heruwati Endang S. 
Published: May 2017

SUMMARYCarrageenan extracted from Eucheuma spinosum harvested from three different coastal sea regions, where this alga has been mainly cultivated, were determined for their chemical and physical characteristics. The carrageenan was extracted from the seaweed using hot alkali followed by precipitation, drying, and milling. The carrageenan properties were determined in terms of yield, ash, mineral, sulfate content, functional group, molecular weight, and viscosity profile. Physical characteristics of carrageenan were evaluated by a texture analyzer for gel strength and a rapid visco analyzer for viscosity. The yield of carrageenan from Sumenep (34.81 ± 5.83%) and Takalar (37.16 ± 3.26%) was found to be relatively higher than that of Nusa Penida (25.81 ± 1.93%). The calcium content was higher than magnesium, potassium and sodium content, and no cadmium, lead, mercury, and arsenic detected in all carrageenan. The ash content was around 29%; while, the sulfate content was in the range of 30–32%, and those were not different in all carrageenan. The presence of sulfate content was identified by FTIR at absorption band of 1373 cm−1. It was found that the molecular weight of carrageenan from Takalar were relatively higher and the gel strength of carrageenan from Takalar were significantly higher than that of carrageenan from Nusa Penida and Sumenep. Likewise, upon cooling from 80 to 20°C, the viscosity profile of carrageenan from Takalar characterized by higher viscosity compared to that of carrageenan from Sumenep and Nusa Penida. These results indicated that carrageenan from Nusa Penida, Sumenep, and Takalar were identified as iota‐carrageenan with similar physico‐chemical characteristics except for the gel strength, viscosity profile upon cooling from 80 to 20°C and the yield.
Taxonomic revision of Dictyochales (Dictyochophyceae) based on morphological, ultrastructural, biochemical and molecular data
Authors: Chang Fook Hoe , Sutherland Judy , Bradford‐Grieve Janet 
Published: May 2017

SUMMARYThe taxonomy of the siliceous members of Dictyochales has been based exclusively on the structure of their silica skeletons. In this study, other morphological, ultrastructural, pigment and molecular characters, in addition to the silica skeletons, were used in the systematics of the siliceous members of this group. As very little is known about the ultrastructure of Dictyocha octonaria, cells of both the skeleton‐bearing and naked forms were also studied. A cladistic analysis based on morphological data and a molecular phylogeny based on nuclear coded small subunit ribosomal DNA retrieved a well‐supported monophyletic Dictyochales. D. octonaria and D. speculum were resolved together with strong support. There was no support for a clade for the three species currently placed in Dictyocha; D. fibula is clearly distinct from the other two Dictyocha taxa, D. speculum and D. octonaria. It is highly likely there are two or three undescribed species within D. octonaria/D. speculum clade and two undescribed genera within the Dictyochales, based on the positions of sequences from uncultured eukaryotes present in GenBank. These findings necessitate a taxonomic revision of the three siliceous, skeleton‐bearing species. Because D. fibula is the type species of Dictyocha, we propose that D. octonaria and D. speculum be reassigned respectively to the genus Octactis as O. octonaria Hovasse and O. speculum (Ehrenberg) F. H. Chang, J. M. Grieve & J. E. Sutherland, comb. nov.
Genome Sequence of a Marine Spirillum, Oceanospirillum multiglobuliferum ATCC 33336
T
, Isolated from Japan
Authors: Carney Joshua G. , Trachtenberg Ariel M. , Rheaume Bruce A. , Linnane Joshua D. , Pitts Natalie L. , Mykles Donald L. , MacLea Kyle S. 
Published: May 2017

ABSTRACT

Oceanospirillum multiglobuliferum
ATCC 33336
T
is a motile gammaproteobacterium with bipolar tufted flagella, noted for its low salt tolerance compared to other marine spirilla. This strain was originally isolated from the putrid infusions of
Crassostrea gigas
near Hiroshima, Japan. This paper presents a draft genome sequence for
O. multiglobuliferum
ATCC 33336
T
.
Whole-Genome Sequence of the Bacteriophage-Sensitive Strain Campylobacter jejuni NCTC12662
Authors: Gencay Yilmaz Emre , Sørensen Martine C. H. , Brøndsted Lone 
Published: May 2017

ABSTRACT

Campylobacter jejuni
NCTC12662 has been the choice bacteriophage isolation strain due to its susceptibility to
C. jejuni
bacteriophages. This trait makes it a good candidate for studying bacteriophage–host interactions. We report here the whole-genome sequence of NCTC12662, allowing future elucidation of the molecular mechanisms of phage–host interactions in
C. jejuni
.
Draft Genome Sequence of
Acidihalobacter ferrooxidans
DSM 14175 (Strain V8), a New Iron- and Sulfur-Oxidizing, Halotolerant, Acidophilic Species
Authors: Khaleque Himel N. , Ramsay Joshua P. , Murphy Riley J. T. , Kaksonen Anna H. , Boxall Naomi J. , Watkin Elizabeth L. J. 
Published: May 2017

ABSTRACT

The use of halotolerant acidophiles for bioleaching provides a biotechnical approach for the extraction of metals from regions where high salinity exists in the ores and source water. Here, we describe the first draft genome of a new species of a halotolerant and iron- and sulfur-oxidizing acidophile,
Acidihalobacter ferrooxidans
DSM-14175 (strain V8).
Certain Topological Indices of Titania Carbon Nanotubes TiO2(m, n)
Authors: Gao Wei , Jamil Muhammad Kamran , Farahani Mohammad Reza , Imran Muhammad 
Published: May 2017

Let G(V, E) be a simple graph. Then for an edge e = uv∈e(G), nu is the number of vertices lying closer to v than u, nv is analogously. The second geometric-arithmetic index and second atom-bond-connectivity
indices are defined as GA2(G) = <mml:math display="block"> <mml:msub> <mml:mo>∑</mml:mo> <mml:mrow> <mml:mi>u</mml:mi><mml:mi>v</mml:mi><mml:mo>∈</mml:mo><mml:mi>E</mml:mi><mml:mo
stretchy="false">(</mml:mo><mml:mi>G</mml:mi><mml:mo stretchy="false">)</mml:mo> </mml:mrow> </mml:msub> <mml:mo stretchy="false">(</mml:mo><mml:mn>2</mml:mn><mml:msqrt> <mml:mrow> <mml:msub> <mml:mi>n</mml:mi>
<mml:mi>u</mml:mi> </mml:msub> <mml:msub> <mml:mi>n</mml:mi> <mml:mi>v</mml:mi> </mml:msub> <mml:mo stretchy="false">)</mml:mo> </mml:mrow> </mml:msqrt> <mml:mtext> / (</mml:mtext><mml:msub>
<mml:mi>n</mml:mi> <mml:mi>u</mml:mi> </mml:msub> <mml:mo>+</mml:mo><mml:msub> <mml:mi>n</mml:mi> <mml:mi>v</mml:mi> </mml:msub> <mml:mtext>)</mml:mtext> </mml:math>, and ABC2
= <inline-formula> <mml:math display="block"> <mml:msub> <mml:mo>∑</mml:mo> <mml:mrow> <mml:mi>u</mml:mi><mml:mi>v</mml:mi><mml:mo>∈</mml:mo><mml:mi>E</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>G</mml:mi><mml:mo
stretchy="false">)</mml:mo> </mml:mrow> </mml:msub> <mml:msqrt> <mml:mrow> <mml:mo stretchy="false">(</mml:mo><mml:msub> <mml:mi>n</mml:mi> <mml:mi>u</mml:mi> </mml:msub> <mml:mo>+</mml:mo><mml:msub>
<mml:mi>n</mml:mi> <mml:mi>v</mml:mi> </mml:msub> <mml:mo>−</mml:mo><mml:mn>2</mml:mn><mml:mo>/</mml:mo><mml:mo stretchy="false">(</mml:mo><mml:msub> <mml:mi>n</mml:mi> <mml:mi>u</mml:mi>
</mml:msub> <mml:msub> <mml:mi>n</mml:mi> <mml:mi>v</mml:mi> </mml:msub> <mml:mo stretchy="false">)</mml:mo><mml:mo>,</mml:mo> </mml:mrow> </mml:msqrt> </mml:math> </inline-formula>, respectively. In
this paper, we compute the second versions of geometric arithmetic and atom bond connectivity indices of Titania carbon Nanotubes TiO2(m, n).
Eksistensi Konsep Nilai “Luan dan Teben” sebagai Pembagian Ruang pada Level Makro Berdasarkan Nilai Tradisional Bali di Wilayah Selatan Kabupaten Badung
Authors: Budhiari Ni Made Dwi Sulistia , Buchori Imam 
Published: May 2017

Propinsi Bali telah memiliki nilai-nilai kearifan lokal sebagai konseptual dalam pembangunan wilayahnya. Tatanan nilai konseptual ini merupakan suatu elaborasi yang diterapkan secara komprehensif dan sistematis pada setiap aspek pembangunan. Konsep nilai yang menjiwai unsur-unsur tersebut dijiwai oleh nilai-nilai Budaya yang diterjemahkan ke dalam wujud keruangan. Setiap konsep nilai tersebut masing-masing nilai memiliki wilayah yang bersifat madya ( tengah ) . Sistem perzoningan tersebut menghasilkan wilayah dengan peruntukkan untuk jenis kegiatan tertentu, yang bertujuan untuk menjaga keseimbangan makrokosmos dan mikrokosmos. Dewasa ini arah pembangunan yang terjadi di Kabupaten Badung dirasakan mulai tidak terkendali, hal ini dikarenakan eksistensi Bali sebagai ODTW, mengakibatkan tingginya minat berinvestasi yang pada akhirnya memberikan dampak positif dan negatif. Fenomena ini menarik dilakukan suatu kajian, mengingat dalam pemanfaatan ruang di wilayah Bali harus berdasarkan pada konsep pembagian ruang makro yang tersirat dalam aturan positif. Berdasarkan hasil analisa dengan melakukan perbandingan antara peta overlay pemanfaatan ruang terhadap konsep nilai “local genius” pembagian ruang pada level makro di wilayah Selatan Kabupaten Badung, maka dapat dilihat bahwa eksistensi dari konsep nil ai tersebut telah mengalami pergeseran secara luasan dan tidak terdapat lagi jenis peruntukkan yang mengkhusus seperti yang telah ditentukan sesuai konsep nilai tersebut.Kata kunci: konsep nilai, ruang makro, tradisional Bali
Congo red fluorescence upon binding to macromolecules – a possible explanation for the enhanced intensity
Authors: Zemanek Grzegorz , Jagusiak Anna , Chłopaś Katarzyna , Piekarska Barbara , Stopa Barbara 
Published: May 2017

Abstract
The present study attempts to explain the reason for the selective generation of an increase in intensity of Congo red (CR) fluorescence as an effect of the dye interacting with proteins and polysaccharides. This supramolecular dye, which creates ribbon-shaped micelles in aqueous solutions when excited with blue light (470 nm), presents low fluorescence with a maximum within the orange-red light range (approximately 600 nm). In the same conditions, CR-stained preparations of heat-denatured proteins, some native proteins (e.g. cell surface receptors) and cellulose show intense orange-red fluorescence when observed using a fluorescence microscope. The fluormetric measurements showed that the factors that cause the dissociation of the ribbon-shaped CR micelle – ethanol, urea, dimethyl sulfoxide (DMSO) and cholate – all contributed to a significant increase in the fluorescence intensity of the CR solutions. The fluorescence measurements of CR bound to the immunoglobulin light lambda (L λ) chain and soluble carboxymethyl cellulose (CMC) showed a fluorescence intensity which was many times higher. In the case of the denatured (65°C) immunoglobulin L λ chain, the fluorescence intensity significantly exceeded the values observed for the factors which break down the CR micelles. The dissociation of the ribbon-shaped micelles and the complexation of the monomeric CR form with polymers are two of the factors explaining the intense fluorescence of protein and polysaccharide preparations stained with CR.
Trade and growth in a model of allocative inefficiency
Authors: Cothren Richard , Radhakrishnan Ravi 
Published: May 2017

AbstractThe empirical evidence on the causal relationship between international trade and economic growth is inconclusive. While some studies show that trade leads to growth, others have pointed to a reverse causation. In this paper, we develop a model of international trade and productivity growth in the presence of a misallocation of resources. Misallocation in a country arises as a result of lobbying by firms to establish barriers to the competitive allocation of labor. Misallocation prevents the country from exploiting its technological comparative advantage and leads to a reduction in the volume of trade in the absence of any explicit trade barriers. In the model, whether barriers diminish or worsen with productivity growth depends on the extent of the initial resource misallocation. If the initial resource misallocation is not severe, then productivity growth leads to diminishing barriers and vice versa. In either case, productivity growth strengthens the comparative advantage over time and therefore increases the volume of trade.
Privatization Neutrality Theorem in Free Entry Markets
Authors: Matsumura Toshihiro , Okumura Yasunori 
Published: May 2017

AbstractIt is known that if the number of entering firms is endogenous (free entry markets), privatization is not necessarily welfare neutral in mixed oligopolies under a uniform production subsidy policy. We revisit this problem by considering another policy tool, the output floor regulation. We investigate three free entry models with different time structures, a Cournot and two Stackelberg models. We find that neutrality is restored in free entry markets under the optimal output floor regulation, regardless of the time structure.
Preparation, calibration and evaluation of the First International Standard for human C-peptide
Authors: Moore Melanie , Dougall Thomas , Ferguson Jackie , Rigsby Peter , Burns Chris 
Published: May 2017

Abstract

Background:
Measurement of C-peptide by immunoassay contributes to the diagnosis of a number of disorders related to β cell function. Stocks of the current international reference reagent (IRR) for C-peptide, used to calibrate these immunoassays, are exhausted, and this report summarises the international study to establish a replacement World Health Organization (WHO) international standard (IS) to maintain the availability of a globally available reference material and support efforts to standardise C-peptide assays.

Methods:
The study was conducted in three phases; phase I involved the assignment of a value to a primary calibrant in mass units by amino acid analysis and phase II applied this value to the calibration of a candidate standard, 13/146, by reversed phase high-performance liquid chromatography (RP-HPLC) assay. In phase III, the candidate standard was compared to the first IRR by current immunoassays to assess its suitability to serve as an IS.

Results:
Calibration of the candidate standard by RP-HPLC gave a final estimated content of 8.64 μg/ampoule with expanded uncertainty of 8.21–9.07 μg/ampoule (95% confidence; k=2.45). The candidate standard also appears sufficiently stable to serve as an IS, based on HPLC analysis of accelerated thermal degradation samples of 13/146, and was also shown to have appropriate immunological activity. A difference in bias approach was used to assess the commutability of 13/146 with human serum and urine samples. With the exception of two laboratories, the candidate standard demonstrated commutability with respect to the serum and urine samples included in this study.

Conclusions:
The candidate standard, 13/146, is suitable to serve as the First International Standard for human C-peptide, and it has been formally adopted by the Expert Committee on Biological Standardisation of the WHO.
On Kiguradze’s problem on power-law asymptotic behavior of blow-up solutions to Emden–Fowler type differential equations
Authors: Astashova Irina V. 
Published: May 2017

Abstract
For higher-order Emden–Fowler type equations with regular nonlinearity, the asymptotic behavior of their blow-up solutions is investigated.
It is proved that for weakly superlinear differential equations, all such solutions have power-law asymptotic behavior.
Production of hemicellulose oligomers from softwood chips using autohydrolysis followed by an enzymatic post-hydrolysis
Authors: Deloule Vivien , Chirat Christine , Boisset Claire , Toussaint Bertrand , Chroboczek Jadwiga 
Published: May 2017

Abstract
In the context of value added valorization of hemicelluloses (HCs), their soft extraction by autohydrolysis (AH) of softwood (SW) chips has been optimized via the temperature/time parameters (170°C/2 h, 170°C/1 h and 150°C/1 h). Two enzyme mixtures containing mainly a glucanase and a mannanase were used to decrease the degree of polymerization (DP) of the extracted HCs. Hydrolysates containing HCs were analyzed in terms of monomers and oligomers, molecular weight distribution (MWD) and chemical composition. The MW was strongly dependent on AH conditions: most of the water-soluble HCs with 1800 Da MW were obtained at 150°C/1 h. The parameters 170°C/2 h gave rise to MWs<1800 Da. Enzymatic hydrolysis (EH) reduced efficiently the DP of HCs, and the glucosidase was more efficient than the mannanase, but the former also hydrolyzed more oligomers into their monomeric components.