bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation, evaluation & comparison of traditional poly herbal shampoo powders with marketed formulation
Authors: PAVAN AMPAPURAM RAJESH , Hima Bindu K , Prasanna Kumari M , Maddileti R , Anitha Lakshmi G 
Published: September 2024

The aim of present work is to formulate poly herbal powder by using different natural herbs like Aswagandha, Tulsi, Ginger, Hibiscus, Aloe vera, Amla and Soap nut to have safety and effectiveness which can avoid toxic effects by chemical ingredients and prepared formulations were compared with marketed poly herbal shampoo. Prepared formulation strengths hair growth, prevents hair fall, dandruff and also acts as antibacterial conditioner and foaming agent without affecting or damaging hair. All the herbs have been selected to formulate poly herbal traditional shampoo powder on the basis of traditional system with scientific modern uses of poly herbs. In this present work herbs like Aswagandha, Tulsi, Ginger, Hibiscus, Aloe vera, Amla and Soap nut were collected, dried, powdered and sieved by passing through sieve no.60, stored in an air tight container and used for further formulation. Then the powders were formulated into four different formulations namely F1, F2, F3, F4 and evaluated for their organoleptic properties like color, odor and texture etc., General powder characteristics like angle of repose, bulk density and true density etc. and physiochemical properties like pH, moisture content, total ash contents, acid insoluble ash, other parameters evaluated were dirt dispersion and foaming capacity. All the four formulations offered good results in all the evaluation tests. The organoleptic characteristics were found to be good, general powder characteristics results were in specified limits and physicochemical evaluation like pH, foaming action, Dirt dispersion were found to yield good satisfactory results. So, the present work successfully formulated poly herbal traditional shampoo powder which meets the modern uses of hair without causing any damage to both skin and hair. Further the Scope of work need to be extended to carry out the stability studies.
Keywords: Poly herbal, Traditional
A new stability indicating RP-HPLC method for estimation of Osimertinib Mesylate
Authors: Chakradhar Talluri , Mondal Sumanta , Vanapalli Goutham Kumar 
Published: September 2024

A simple stability-indicating high-performance liquid chromatographic method was developed and validated for the determination of Osimertinib Mesylate in tablet dosage forms. Reversed-phase chromatography was performed on Shimadzu Model CBM-20A/20 Alite, using a mixture of 0.1% T.E.A and methanol (50:50, v/v) as mobile phase with a flow rate of 1.0 mL/min. Detection was carried at 211nm. Linearity was observed over the concentration range of 10–400 μg/mL (R2 = 0.9992) with regression equation y = 125927x + 192648 Osimertinib Mesylate was subjected to stress conditions (acidic, alkaline, oxidation and thermal degradation) and validated as per ICH guidelines. The validated method can be applied to perform long-term and accelerated stability studies of Osimertinib Mesylate formulations.
Enhancement of Sulfamethoxazole by Solid Dispersion using Spray Dryer Technique
Authors: Gadakh Pravin , Valvi Surup Singh , Jagatp Shubham , Gomase Amol 
Published: September 2024

The aim of this study was to enhance the solubility of SMZ by preparing solid dispersion using a spray dryer. Different polymers were used to study their effect on the solubility of SMZ. Effect of polymer on solubility of drug in the form of solid dispersion was studied by determining the solubility of each solid dispersion separately. It was observed that solubility of drug changes with change in the polymer. As a result of this study, it was found that solubility of SMZ was significantly enhanced by solid dispersion with the polymers especially with the PVP K30 and HPMC E15.
Keywords SMZ, Solubility, Solid dispersion, Spray dryer.
Formulation and Evaluation of Sustained Release Matrix Tablets of Isoxsuprine Hydrochloride by Direct Compression Method
Authors: Jain Priyanshi , Ekta , , Kushwaha R S , Khan Azaz 
Published: September 2024

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. Isoxsuprine hydrochloride is structurally a novel vasodilator. The short biological half-life (5±2 hr) and the fast clearance make the drug, a suitable candidate for the development of modified release formulation. A novel oral controlled delivery system for isoxsuprine hydrochloride was developed and optimized. Matrix tablets of isoxsuprine hydrochloride were prepared by using hydroxypropylmethylcellulose (HPMC K15), Gaur Gum and PVP K 30 as polymer substance to achieve required sustained release profile. The matrix tablets were prepared by direct compression method which is now days considered a cost effective and simple method of manufacturing. It is considered as an appropriate method for hygroscopic and thermolabile substances. Six formulations of different polymer percentages were formulated (F1-F6). Pre-compression parameters were evaluated. The influence of matrix forming agents and binary mixtures of them on isoxsuprine hydrochloride release was investigated. The formulated tablets were characterized by hardness, friability, thickness, weight variation and in vitro drug release. The formulated tablets had acceptable physicochemical characters. There was no chemical interaction found between the drug and excipients throughout FT-IR and UV study thought of in the present investigation. The quantity of isoxsuprine hydrochloride present in the tablets and the release medium were estimated by a simple, rapid and validated UV method. The dissolution results show that increased amount of polymer resulted in reduced and extended drug release. F4 formulation is the optimum formulation due to its better targeting profile in terms of release. First order kinetic profiles were achieved. This formulation may provide an alternative for oral controlled delivery of isoxsuprine hydrochloride and be helpful in the future treatment of peripheral vascular disease.
Keywords: Isoxsuprine hydrochloride, HPMC K15, Gaur Gum, PVP K30, Direct compression method, Dissolution
Oviasose: A Novel Oligosaccharide from the Milk of Gaddi Sheep (Ovis aries)
Authors: Singh Pushpraj , Shahi Sanyogita , Deepak Desh 
Published: September 2024

Oligosaccharides are the most biologically diverse and important carbohydrate among biological system, present as natural constituents in fruits, vegetables, milk, blood, bacteria fungus etc. Oligosaccharides present in milk protect infants by reducing the number of pathogen infections and promoting the development of the intestinal epithelium. Oligosaccharides isolated from sheep milk strongly stimulate the immune system and are used for treatment of immune system related disorders. Keeping above mentioned biological activities of Gaddi sheep’s (Gaddi is a breed of sheep found at higher altitude of Himalayan region) milk oligosaccharides in mind we have isolated a novel oligosaccharide namely Oviasose from sheep’s milk and elucidated its structure by chemical degradation & spectroscopic techniques (like 1H NMR, 13C NMR, COSY, TOCSY, HSQC and HMBC) and Mass Spectrometry. The structure of Oviasose was established by comparing the chemical shift (1H NMR and 13C NMR) of anomeric signals and other important signals of isolated milk oligosaccharide with the chemical shifts of known milk oligosaccharides, 2D-NMR and mass of Oviasose.
Keywords: Sheep milk, Oligosaccharides, NMR, Oviasose.
Effervescent Floating Drug Delivery System: A review
Authors: Pakhale Nilesh V , Gondkar S.B , Saudagar R.B. 
Published: September 2024

Effervescent floating drug delivery systems release gas CO2, thus reduce the density of the system and remain buoyant in the stomach 2 for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. In the present article we will discuss in detail about effervescent agent and mechanism of effervescent floating drug delivery system. Oral sustained release gastro-retentive dosage forms offer many advantages for drugs with the absorption from upper parts of the gastro intestinal tract. Gastric emptying is a complex process and it is highly variable. The floating drug delivery systems are useful methods to avoid this variability which increases the retention time of the drug delivery systems for more than 12 hours. This review article is in pursuit of giving detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. At attempt has been made in this review article to introduce the readers to current development in floating drug delivery system,
Keywords: Effervescent system, Floating drug delivery system, Effervescent agent, floating lag time, Gastric residence time.
Physicochemical evaluation, in vitro anti-inflammatory, in vitro anti-arthritic activities and GC-MS analysis of the oil from the leaves of Gaultheria fragrantissima Wall of Meghalaya
Authors: Uriah Tiewlasubon , Rai Swarnim , Mohanty J. P. , Ghosh Pallab 
Published: September 2024

The aim of our present study is to assess the in vitro anti-inflammatory activity against denaturation of proteins whereby the test oil sample at different concentrations was incubated with egg albumin and the absorbance was determined at 660 nm. The anti-arthritic activity was investigated by two methods; firstly, in-vitro method by bovine serum protein denaturation and the absorbance was measured at 255 nm and secondly in vitro method by egg albumin denaturation where the absorbance was measured at 660 nm. In all the studies diclofenac sodium was used as thestandard drug. The physicochemical parameters like colour, solubility, refractive index, boiling point, specific gravity, carbon residue, iodine value, acid value, ester value were evaluated. The different components of the volatile oil were determined by GC-MS analysis. Ten organic compounds were identified out of which Methyl salicylate C8H8O6 was found to be the most dominant organic compound of Gaultheria fragrantissima oil (97.7%). The present results exhibited a concentration dependent inhibition of protein (albumin) denaturation by the test oil. The study reveals that diclofenac sodium was less effective when compared with the test oil. From the present findings it can be concluded that the essential oil of Gaultheria fragrantissima from Meghalaya possessed significant anti-inflammatory and anti- arthritic effects against the denaturation of protein in vitro. This effect could be due to the high content of methyl salicylate (97.7%) which is an inflammation-fighting compound. The high altitude and conducive climatic conditions of Meghalaya make wintergreen from this region far more superior in comparison to the ones grown in other parts of the world.
Keywords: Gaultheria fragrantissima, anti-inflammatory, anti-arthritic, GC-MS, methyl salicylate.
Formulation, Development and Evaluation of Floating Microsphere of Losartan Potassium Using Natural Polymer
Authors: Patel Bharti , Kushwaha R S , Jain Shailesh 
Published: September 2024

Floating drug delivery system is one of the novel drug delivery system. Floating drug delivery system have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. Various approaches have been used to retain the dosage form in stomach as a way of increasing the gastric residence time, including floatation systems, high-density systems, mucoadhesive systems, magnetic systems, unfoldable, extensible, or swellable systems and superporous hydrogel systems. The objective of this study was to prepare and evaluate floating microspheres of losartan potassium for the prolongation of gastric residence time. The microspheres were prepared by solvent diffusion–evaporation method using ethyl cellulose, hydroxypropylmethylcellulose and sodium alginate as natural polymers. Ethanol/dichloromethane blend was used as solvent in a ratio of 1:2. The floating microspheres were evaluated for flow properties, particle size, zeta potential, drug entrapment, as well as In-vitro release studies and stability studies. The shape and surface morphology of the microspheres were characterized by optical and scanning electron microscopy. The floating microspheres showed particle size, buoyancy, drug entrapment efficiency and yield in the ranges of 331.6 nm, 69±3 to 81±2%, and 60.25±0.25 to 75.65±0.74% and 69.98±0.56 to81.47±0.52%, respectively. Maximum drug release after 12 hr was 99.45 % for formulations F4. Scanning electron micrographs indicate pores both on the surface and interior of the microspheres. Accelerated stability study was also performed for three months indicated that optimized formulation was stable. The developed losartan microsphere system is a promising floating drug delivery system for oral sustained administration of losartan.
Keywords: Losartan Potassium, Floating microspheres, Drug entrapment, In-vitro drug release, Ethyl cellulose, Hydroxyl propyl methylcellulose
Dhattura Lavana: An Eccentric Salt Preparation in Folklore
Authors: Amrutha O.P. , Govinda Sharma K. , Ajith Kumar G. , Savitha H.P. 
Published: September 2024

Lavana kalpana is a formulation in Ayurveda which is prepared from combination of certain drugs with lavana (Salt). A particular heating pattern is followed for drugs and lavana in an earthen crucible by subjecting it to putapaka. Number of lavana kalpana like Narikela lavana Arka lavana and other such formulations are being practiced in Ayurveda. Dhattura lavana is also a formulation of Dhattura and lavana used in alcohol dependence. An attempt was made in this work to gather the information about this formulation. It is observed that this formulation is used by traditional practioners of Kerala. The reference of Dhattura lavana could not be found in the books or literatures of Ayurveda. Deviating from the general method of preparation of putapaka, Dhattura lavana is prepared in a unique way. In this formulation, a decoction of Dhattura is prepared first and to that equal amount of lavana is added and dehydrated.
Keywords: Dhattura lavana, Lavana kalpana, madatyaya, tadarthakari chikitsa.
Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Tenofovir Alafenamide Fumarate and Emtricitabine in Bulk and Tablet Dosage Form
Authors: Kalamkar Chaitali S , Bhawar Sanjay B 
Published: September 2024

New Analytical method was developed for the estimation of Emtricitabine and Tenofovir Alafenamide Fumarate in drug product by liquid chromatography. The chromatographic separation was achieved on Cosmosil C18 column (250mm×4.6ID, 5µm) at ambient temperature. The separation achieved employing a mobile phase consists of Methanol:water(80:20v/v). The flow rate was 0.8ml/ minute and ultra violet detector at 252nm. The average retention time for Emtricitabine and Tenofovir Alafenamide Fumarate found to be 4.277min and 5.293min. The proposed method was validated for selectivity, precision, linearity and accuracy. All validation parameters were within the acceptable range. The assay methods were found to be linear from 10-50µg/ml for Emtricitabine and 15-75µg/ml for Tenofovir Alafenamide Fumarate.
Keywords: Emtricitabine and Tenofovir Alafenamide Fumarate, HPLC, Methanol and validation.
Pharmacognostical and Preliminary Phytochemical Screening of Nardostachys jatamansi Dc Rhizome, Achyranthus aspera Linn plant and Trachyspermum ammi Linn fruit
Authors: Shah Vrunda V , Shah Vipul K , Santani Devdas D 
Published: September 2024

Nardostachys jatamansi, Achyranthus aspera and Trachyspermum ammi are very important medicinal plants which are traditionally used in many medical conditions. The present study involves Pharmacognosy and preliminary phytochemical investigations of the rhizomes, whole plant and fruit parts of above three plants respectively .This study consist of the morphological and microscopical study of the plant; the phytochemical screening and testing for alkaloids, glycosides, tannins, steroids and flavonoids; TLC study and HPTLC fingerprinting. The parameters from the above were recorded with an objective of drawing an attention on the plant as well as a reference for further scientific investigations.
Keywords: Nardostachys jatamansi, Achyranthus aspera, Trachyspermum ammi, Flavanoids, Microscopical, Pharmacognosy.
Nanosponges: A Novel Trend for Targeted Drug Delivery
Authors: Jagtap Sneha R. , Bhusnure Omprakash G. , Mujewar Imran N. , Gholve Sachin B. , Panchabai V.B. 
Published: September 2024

Effective targeted drug delivery system has been a dream for a long time, but it has been largely frustrated by the complex chemistry that is involved in the development of new systems. Topical drug delivery system has many problems like poor permeability, skin irritation, allergic reactions etc. major problems of newly developed chemical entities is their poor solubility in water and pharmacokinetic issues. These poorly-water soluble drugs show many problems in formulating them in conventional dosage forms and the critical problems associated is its very low bioavailability. The invention of Nanosponge has become a significant step towards overcoming these problems. Nanosponge is tiny sponges with a size about a virus (250nm-1um), which can be filled with a wide variety of drugs. Nanosponge play vital role in targeting drugs delivery in a controlled manner. This sponge can circulate around the body until interact with specific target site and stick on surface and releasing drug in controlled manner both lipophilic and hydrophilic drugs are incorporated in nanosponge . Important characteristics of these sponges are their solubility in aqueous from and suitable for the drugs with poor solubility. This review is focusing on the preparation method, applications of nanosponge, factor in the field of drug delivery.
Keywords: nanosponge, poor solubility, Biodegradable polymers, synthesis, preparation
A Review on Pharmacological Activities of Calotropis Procera
Authors: Mali Rohit P , Rao Priya S , Jadhav R. S. 
Published: September 2024

The plant Calotropis procera (Aiton) Dryand belong to the Apocynaceae family it is popularly known as “Rui” in Marathi, “ Mudar” in hindi other common name include Rubber Bush, Apple of sodom. (India & Pakistan). The bark and leaves are known to show wound healing, shows anti-Hyperglycemic effect, Analgesic, Anti pyretic, neuromuscular blocking activity, Purgative, anti-cancer activities. The phytochemistry of plant reveals presence of triterpenoids, flavonoids, cardiac glycosides, cardenolides, anthocyanins, α-amyrin, β-amyrin, lupeol, β-sitosterol, flavanols, mudarine, resins, a powerful bacteriolytic enzyme calactin, a nontoxic proteolytic enzyme calotropin, and a wax was isolated from the heartwood of Calotropis procera. The present review focuses on pharmacological activities of Calotropis procera.
Keywords: Calotropis procera, anti- Hyperglycemic effect, wound healing, pharmacological activities.
Rituximab therapy for Severe and Persistent Lichenoid drug-reaction
Authors: El-Reshaid Kamel , Al-Bader Shaima 
Published: September 2024

We report on a patient with severe and fixed lichenoid drug-reaction. She did not respond to 2 months treatment with high-dose corticosteroids. Hence, Rituximab was given. One month later, her lesions improved and remained stable for 14 months of follow up.
Keywords: fixed drug reaction, Prednesone, Rituximab.
Gandhahastadi Agada: A Review
Authors: Vidyavati T , Hussain Gazala , Nataraj H.R , Srinidhi S 
Published: September 2024

Agada Tantra is a branch of Ayurveda that deals with the science of toxicology. It deals with the treatment of various poisons. For the management of poisons various treatment procedures have been described, one among them is the use of formulations taken internally. Varied formulations are described of just herbal, animal origin drugs and also herbo- mineral in origin. One among them is Gandhahastadi agada that is mentioned in the treatment of visha. It is a formulation of nineteen drugs and the bhavana dravya is of animal origin drugs namely Ajamutra (Goat’s urine), Go pitta (cow’s bile) and Ashwa pitta (horse’s bile) alternatively for seven days. This is indicated in various conditions such as Visuchika, Pilla, Arbuda, Arma, Kandu, Kshaya (consumption), Dourbhalya (asthenia), Madatyaya (alcoholism), Pandu (anaemia), Moha (unconsciousness), etc. and also as nasya in sarvajwara (all types of fever).
Keywords: Gandhahastadi Agada, visha, formulation
Preparation, Quality Control and Stability Studies of Avipattikar churna
Authors: Patil Sonali , Shah Shruti 
Published: September 2024

Throughout world more people are turning to use medicinal plant products in healthcare system. Worldwide need of alternative medicine has resulted in growth of natural product markets and interest in traditional systems of medicine. Proper integration of modern scientific techniques and traditional knowledge is important. There is a growing focus on the importance of traditional health care system (viz. Ayurveda, Unani, Homoeopathy, Yoga) in solving health care problems. Systematic approach and well-designed methodologies for the standardization of herbal formulations are developed. In the present study preparation of Avipattikar Churna was carried out and then it was subjected to various quality control parameters. The formulation was prepared as per the guidelines mentioned in pharmacopeia & various tests performed were physical properties (such as moisture content) , biochemical test, ash value, HPLC, IR spectroscopy. The above parameters can be used as preliminary standardization for quality control of Avipattikar Churna .
Keywords: Standardization, herbal formulation, Avipattikar Churna, Physicochemical properties.
Formulation Development and Evaluation of Leaf Extract of Ficus benghalensis for Antidiabetic Activity
Authors: Laware Ravindra B. , Pulate Shubhangi P. , Dighe Santosh B , Bhawar Sanjay B 
Published: September 2024

Herbal products are known for their inherent property i.e. comparatively safe and economic. In present study, leaf extract of ficus benghalensis was evaluated for antidiabetic activity. The aim of the research work was to formulate and evaluate capsule dosage form of ethanolic extract. Leaves of Ficus benghalensis collected from local area of Ahmednagar district and shade dried. Ethanolic, Hydroalcoholic and petroleum ether extracts were prepared using soxhlet apparatus. Extracts were screened for antidiabetic activity using alloxan induced diabetes in rats. Oral glucose tolerance test was measured as parameter to check antidiabetic activity. Ethanolic extract was found most effective among them. Granules were prepared using ethanolic ectract and filled in capsule. Capsule were evaluated for parameters including uniformity of weight, disintegration time.
Keywords: Ficus benghalensis, Ethanolic extract, Antidiabetic activity