bluuebunny/crossref_metadata_2025_split huggingface dataset:
PTPRZ1-Targeting RNA CAR T Cells Exert Antigen-Specific and Bystander Antitumor Activity in Glioblastoma
Authors: Martinez Bedoya Darel , Marinari Eliana , Davanture Suzel , Castillo Cantero Luis , Erraiss Sarah , Dockerill Millicent , Barluenga Sofia , Winssinger Nicolas , Schaller Karl , Bijlenga Philippe , Momjian Shahan , Voize Christel , Tissot Stéphanie R. , Kandalaft Lana E. , Hammel Philippe , Cosson Pierre , Walker Paul R. , Dutoit Valérie , Migliorini Denis 
Published: September 2024

Abstract
The great success of chimeric antigen receptor (CAR) T-cell therapy in the treatment of patients with B-cell malignancies has prompted its translation to solid tumors. In the case of glioblastoma (GBM), clinical trials have shown modest efficacy, but efforts to develop more effective anti-GBM CAR T cells are ongoing. In this study, we selected protein tyrosine phosphatase receptor type Z (PTPRZ1) as a target for GBM treatment. We isolated six anti-human PTPRZ1 single-chain variable fragments from a human phage display library and produced second-generation CAR T cells in an RNA format. Patient-derived GBM PTPRZ1–knockin cell lines were used to select the CAR construct that showed high cytotoxicity while consistently displaying high CAR expression (471_28z). CAR T cells incorporating 471_28z were able to release IFNγ, IL2, TNFα, granzyme B, IL17A, IL6, and soluble FasL and displayed low tonic signaling. Additionally, they maintained an effector memory phenotype after in vitro killing. In addition, 471_28z CAR T cells displayed strong bystander killing against PTPRZ1-negative cell lines after preactivation by PTPRZ1-positive tumor cells but did not kill antigen-negative nontumor cells. In an orthotopic xenograft tumor model using NOD/SCIDγ mice, a single dose of anti-PTPRZ1 CAR T cells significantly delayed tumor growth. Taken together, these results validate PTPRZ1 as a GBM target and prompt the clinical translation of anti-PTPRZ1 CAR T cells.
Evaluating factors in urban dengue prevention and control during Indonesia's COVID-19
Authors: Boerman Baequni , Nasir Narila Mutia , Karyadi Karyadi 
Published: September 2024

Amidst the COVID-19 pandemic, dengue hemorrhagic fever (DHF) persisted as a critical public health challenge in South Tangerang. This study employed a cross-sectional design and snowball sampling technique to evaluate the engagement of urban communities in dengue prevention, involving 234 participants. Findings indicate that while practices such as container emptying (76.5%) and water storage sealing (57.7%) were prevalent, activities like mosquito larvae inspection (36.3%) and breeding item disposal (34.6%) were less common. Alarmingly, personal protective measures, including mosquito net usage (11.1%) and repellent application (16.7%), were significantly lacking. Statistical analyses revealed notable correlations (p-value&lt;0.05) between dengue prevention behaviours and factors, including beliefs, attitudes towards prevention, support from family and healthcare professionals, and knowledge about dengue prevention. The study highlights a critical disparity in dengue prevention efforts, showing a community bias towards environmental management over personal protection strategies. It calls for increased participation from families and healthcare professionals in dengue prevention initiatives and stresses the need for governmental interventions to improve training for healthcare workers. Ultimately, the study advocates for a comprehensive approach that merges environmental management with personal protective measures, urging governments to adopt integrated strategies for more effective dengue prevention.<p> </p>
Prerequisites for the Positioning of Scientific Disciplines: An Analysis Including Values, Norms, and Science-Related Issues
Authors: Haase Michaela 
Published: September 2024

Abstract
Scientific disciplines are faced with the need to position themselves as part of both science and society. This article explores the foundations of such positioning on the basis of a sociological model of the division of disciplinary labor, interpreted as a general model of the social organization of disciplinary labor, as well as on the basis of models of science and of the science–society relationship. As models of the relationship between science and society, the republican American model and the model of the scientific public sphere embody the normative ideals of autonomous and embedded science that are essential for the positioning of a scientific discipline. With cognition as the main goal of science, the (post-)positivist roots of the close connection between basic research and instrumental knowledge are explored. The transformation discourse testifies to the interest in solving complex problems in democratic science; and the concept of scientific knowledge as a common good links science and society by pointing to the possibility of a public interest in scientific knowledge. The article concludes that a scientific community needs axiological skills in addition to theoretical, methodological, and communicative skills.
Artistic Resistance and Resilience in Sank, or the Patience of the Dead, by Aristide Tarnagda
Authors: Tiendrebeogo Pingdewindé Issiaka 
Published: September 2024

Abstract
Burkina Faso has faced a security crisis unlike any other in its history for the past eight years. The government has lost control of up to 35 % of the national territory, and there are as many as two million internally displaced persons living in the big cities. The emblematic figure of Thomas Sankara, Burkina Faso’s president from 1984 to 1987, has soared beyond the local image of the “upright man” (the ideal to which the very name “Burkina Faso” refers) to that of a globally recognised icon of resistance against imperialism. Theatre artists are inspired to create theatrical performances that “represent” (or “face up”) this great figure, as the recent edition of the Ouagadougou-based biannual theatre festival called Les Récréâtrales invited them to do. This paper emphasises theatre’s contribution to efforts of artistic resilience and resistance in Burkina Faso. It addresses the question: How do Burkinabè artists produce acts of artistic resilience through performance? In other words, does the staging proposed by the Burkinabè playwright Aristide Tarnagda carry the seeds of hope for a Burkina Faso entirely liberated from terrorism? The theory of communication developed by J.L. Austin in How to Do Things With Words (1962) and Anne Ubersfeld’s (1982) semiotic analysis theory provide the key critical concepts of this study.
The Ethiopia-Egypt Controversy on the Renaissance Dam and the Role of a Benefit-Sharing Approach in the Nile Basin
Authors: Alamineh Asabu Sewenet 
Published: September 2024

Abstract
The Nile River has been both an engine of development and a cause of controversy among its riparian states for millennia. This paradox took on an international dimension with the inception of the Grand Ethiopian Renaissance Dam (GERD). Using a qualitative research method, this paper investigates the GERD controversy and the role of a benefit-sharing approach in the Nile Basin. The dam negotiations have been hampered by unjust colonial treaties, the hardline interests of Egypt and Ethiopia, politicisation, uncertainty about the consequences of the dam’s use and lopsided third-party intervention. The paper argues that the adoption of a benefit-sharing approach in the basin can sustain the Nile ecosystem, promote regional peace, increase water flow and decrease unnecessary expenses through modest intraregional cooperation. The resolution of the Nile Basin conflict thus relies on identifying the potential of the basin and on integrated cooperative frameworks adopted by the technocrats of its riparian states and international experts.
Hydro Political Relation in the Eastern Nile Basin
Authors: Mulugeta Getaye , Asress Degu 
Published: September 2024

Abstract
Hydropolitical relations have long attracted the world of academia, and hydrohegemony and counter-hydrohegemony frameworks have recently become important in analysing power relations between riparian states. However, little attention has been given to the hydrohegemonic situation of the Nile River. This study tries to analyse this status, specifically in the Eastern Nile Basin. The data, elicited through unstructured interviews from purposively selected informants, has been analysed thematically. The findings reveal that Egypt aspires to be a hegemon in the basin but is not. Despite its use of different coercive and subtle mechanisms to induce ideational or hegemonic compliance, these have not been successful: Ethiopia has not consented to or accepted Egypt’s claim over the Nile. Concomitantly, since the 1990s, Ethiopia’s position has transcended from veiled to overt contest, which anticipates a new order, challenging the monopolistic position of Egypt.
The City Mayor as a Policy Entrepreneur of Sustainable Development: Evidence from a Highly- Urbanized City in the Philippines, 2016–2019
Authors: Blanco Dennis V. 
Published: September 2024

Abstract
Using the elite and expert interview approaches, the article situates the city mayor of a highly urbanized city in the Philippines as a policy entrepreneur championing sustainable development based on Mintrom and Norman’s (2009) four essential qualities of policy entrepreneurs, namely, social acuity, problem-solving, leading by example, and team-building as supported by the narratives and discourses culled from an elite interview and reinforced by relevant literature, documents, independent sources and scholars. More importantly, the article seeks to discover the policy-entrepreneurial qualities of the city mayor on sustainable development, analyze the sustainable development issues and challenges the city mayor encounter, and synthesize how the city mayor addresses such issues and challenges as a problem-solver. Finally, the article implies the necessity of exploring policy entrepreneurship as a potential research thrust in the context of sustainable development particularly at the local government which is the level of governance closest to the people.
Practices and Challenges in Documenting Endangered Jewish Languages
Authors: Benor Sarah Bunin , Tirosh-Becker Ofra 
Published: September 2024

Abstract
This forum brings together nine researchers to offer their perspectives on the process of language documentation. Questions include how they find speakers, how they conduct their research, and what linguistic data and metadata they collect. We asked about practical and scholarly issues that have arisen in their fieldwork, including speakers avoiding stigmatized linguistic features and exhibiting influences from Modern Hebrew. Some of the points apply specifically to Jewish languages, and others are generalizable to endangered language documentation or even linguistic research more broadly.
Revisiting the “East African Paradox”: CMIP6 Models Also Struggle to Reproduce Strong Observed Long Rain Drying Trends
Authors: Schwarzwald Kevin , Seager Richard 
Published: September 2024

Abstract
Societies in much of the Horn of Africa are affected by variability in two distinct rainy seasons: the March–May (MAM) “long” rains and the October–December (OND) “short” rains. A recent five-season, La Niña–forced drought has renewed concerns about possible anthropogenic drying trends in the long rains, which had partially recovered after a multidecadal drying trend in the 1980s through the 2000s. Despite observed drying, previous generations of global climate models (GCMs) have consistently projected long-term wetting due to increased greenhouse gas concentrations, an East African “paradox” which complicates the interpretation of East African rainfall projections. We investigate the paradox in new phase 6 of the Coupled Model Intercomparison Project (CMIP6) and seasonal forecast models, leveraging an improved observational record and large ensembles to better differentiate internal and forced trends. We find observed drying trends are at the limits of the GCM spread during the peak paradox period, though the recent recovery is comfortably within the model spread. We find that the apparent paradox is largely removed by prescribing sea surface temperatures (SSTs) and is likely caused by the GCM difficulties in simulating observed tropical Pacific SST trends in recent decades. In line with arguments that these SST trends are at least partially forced anthropogenically, we recommend users of future rainfall projections in East Africa consider the possibility of long-term MAM drying despite GCM wetting and call for future model simulations that better sample the expected spread of SSTs.

Significance Statement
Societies in the Horn of Africa depend on the March–May “long” rains and the September–December “short” rains to support agricultural and pastoral practices on rain-fed lands. Recent major droughts have raised worries about possible anthropogenically forced drying trends in the long rains through global climate models (GCMs) project wetting. This East African “paradox” complicates long-term climate adaptation planning. We find the paradox continues in the newest generation of GCMs and seasonal forecast models; though a recent recovery in rainfall is well-captured, the strongest observed drying trends are rare in simulations. The paradox likely arises from known GCM biases in the Pacific Ocean interacting with natural variability. We recommend that researchers and policymakers consider possible long-term drying despite GCM projections of wetting.
γ-Cyclodextrin-metal organic framework as a carrier for trans-N-p-coumaroyltyramine: A study of drug solubability, stability, and inhibitory activity against α-glucosidase
Authors: Niu Dandan , Zhou Danyang , Zhan Mengke , Lei Lijing , Zhu Jinhua , Liu Xiuhua 
Published: September 2024

γ-Cyclodextrin-based metal-organic frameworks (γ-CD-MOF) were successfully synthesized using the solvent diffusion method and applied as carriers for trans-N-p-coumaroyltyramine (N-p-t-CT, NCT) to study the solubability, stability, sustained release and inhibitory activity against α-glucosidase. The solubilization effect of γ-CD-MOF on N-p-t-CT was performed using impregnation (NCT@CD-MOF-1) and co-crystallization (NCT@CD-MOF-2) methods. X-ray diffraction, scanning electron microscope (SEM), fourier transform infrared spectrometer (FTIR), and N2 adsorption/desorption were used to characterize the MOFs before and after loading NCT. The results showed that NCT@CD-MOF-2 had a better solubability for N-p-t-CT, 145.03 μg/mg of drug loading capacity could be achieved, and the solubility of NCT@CD-MOF-2 in water was 366 times higher than free N-p-t-CT. In addition, the stabilities of N-p-t-CT under temperature, UV light and pH conditions were greatly improved after encapsulation in γ-CD-MOF. Furthermore, NCT@CD-MOFs had a sustained release of N-p-t-CT over an extended period in vitro due to the primary encapsulation in pore structures. Notably, γ-CD-MOF loaded with N-p-t-CT showed superior inhibitory activity against α-glucosidase compared to free N-p-t-CT. Cytotoxicity studies demonstrated that NCT@CD-MOF-2 had low toxicity in vitro and perfect biocompatibility with HL-7702 cells, and γ-CD-MOF could reduce the toxicity of free N-p-t-CT at higher concentrations.
Prevalence, predictors and outcomes of self-reported feedback for EMS professionals: a mixed-methods diary study
Authors: Wilson Caitlin , Budworth Luke , Janes Gillian , Lawton Rebecca , Benn Jonathan 
Published: September 2024

Abstract
Background
Providing feedback to healthcare professionals and organisations on performance or patient outcomes may improve care quality and professional development, particularly in Emergency Medical Services (EMS) where professionals make autonomous, complex decisions and current feedback provision is limited. This study aimed to determine the content and outcomes of feedback in EMS by measuring feedback prevalence, identifying predictors of receiving feedback, categorising feedback outcomes and determining predictors of feedback efficacy.

Methods
An observational mixed-methods study was used. EMS professionals delivering face-to-face patient care in the United Kingdom’s National Health Service completed a baseline survey and diary entries between March-August 2022. Diary entries were event-contingent and collected when a participant identified they had received feedback. Self-reported data were collected on feedback frequency, environment, characteristics and outcomes. Feedback environment was measured using the Feedback Environment Scale. Feedback outcomes were categorised using hierarchical cluster analysis. Multilevel logistic regression was used to assess which variables predicted feedback receipt and efficacy. Qualitative data were analysed using content analysis.

Results
299 participants completed baseline surveys and 105 submitted 538 diary entries. 215 (71.9%) participants had received feedback in the last 30 days, with patient outcome feedback the most frequent (n = 149, 42.8%). Feedback format was predominantly verbal (n = 157, 73.0%) and informal (n = 189, 80.4%). Significant predictors for receiving feedback were a paramedic role (aOR 3.04 [1.14, 8.00]), a workplace with a positive feedback-seeking culture (aOR 1.07 [1.04, 1.10]) and white ethnicity (aOR 5.68 [1.01, 29.73]). Feedback outcomes included: personal wellbeing (closure, confidence and job satisfaction), professional development (clinical practice and knowledge) and service outcomes (patient care and patient safety). Feedback-seeking behaviour and higher scores on the Feedback Environment Scale were statistically significant predictors of feedback efficacy. Solicited feedback improved wellbeing (aOR 3.35 [1.68, 6.60]) and professional development (aOR 2.58 [1.10, 5.56]) more than unsolicited feedback.

Conclusion
Feedback for EMS professionals was perceived to improve personal wellbeing, professional development and service outcomes. EMS workplaces need to develop a culture that encourages feedback-seeking to strengthen the impact of feedback for EMS professionals on clinical decision-making and staff wellbeing.
Trends in COPD severe exacerbations, and all-cause and respiratory mortality, before and after implementation of newer long-acting bronchodilators in a large population-based cohort
Authors: Guay Charles-Antoine , Maltais François , Beaudoin Claudia , Carmichael Pierre-Hugues , Laouan Sidi Elhadji Anassour , Perreault Laurie , Sirois Caroline , Provencher Steeve 
Published: September 2024

Abstract
Background
Little is known about the trends in morbidity and mortality at the population level that followed the introduction of newer once-daily long-acting bronchodilators for COPD. The purpose of the study was to evaluate whether the availability of new bronchodilators was associated with changes in the temporal trends in severe COPD exacerbations and mortality between 2007 and 2018 in the older population with COPD; and whether this association was homogeneous across sex and socioeconomic status classes.

Methods
We used an interrupted time-series and three segments multivariate autoregressive models to evaluate the adjusted changes in slopes (i.e., trend effect) in monthly severe exacerbation and mortality rates after 03/2013 and 02/2015 compared to the tiotropium period (04/2007 to 02/2013). Cohorts of individuals > 65 years with COPD were created from the nationally representative database of the Quebec Integrated Chronic Disease Surveillance System in the province of Quebec, Canada. Whether these trends were similar for men and women and across different socioeconomic status classes was also assessed.

Results
There were 130,750 hospitalizations for severe exacerbation and 104,460 deaths, including 24,457 (23.4%) respiratory-related deaths, over the study period (928,934 person-years). Significant changes in trends were seen after 03/2013 for all-cause mortality (-1.14%/month;95%CI -1.90% to -0.38%), which further decreased after 02/2015 (-1.78%/month;95%CI -2.70% to -0.38%). Decreases in respiratory-related mortality (-2.45%/month;95%CI -4.38% to -0.47%) and severe exacerbation (-1,90%/month;95%CI -3.04% to -0.75%) rates were only observed after 02/2015. These observations tended to be more pronounced in women than in men and in higher socioeconomic status groups (less deprived) than in lower socioeconomic status groups (more deprived).

Conclusions
The arrival of newer bronchodilators was chronologically associated with reduced trends in severe exacerbation, all-cause and respiratory-related mortality rates among people with COPD > 65 years. Our findings document population benefits on key patient-relevant outcomes in the years following the introduction of newer once-daily long-acting bronchodilators and their combinations, which were likely multifactorial. Public health efforts should focus on closing the gap between lower and higher socioeconomic status groups.
Cost-effectiveness of proton beam therapy vs. conventional radiotherapy for patients with brain tumors in Sweden: results from a non-randomized prospective multicenter study
Authors: Sampaio Filipa , Langegård Ulrica , de Alva Patricio Martínez , Flores Sergio , Nystrand Camilla , Fransson Per , Ohlsson-Nevo Emma , Kristensen Ingrid , Sjövall Katarina , Feldman Inna , Ahlberg Karin 
Published: September 2024

Abstract
Background
This study assessed the cost-effectiveness of proton beam therapy (PBT) compared to conventional radiotherapy (CRT) for treating patients with brain tumors in Sweden.

Methods
Data from a longitudinal non-randomized study performed between 2015 and 2020 was used, and included adult patients with brain tumors, followed during treatment and through a one-year follow-up. Clinical and demographic data were sourced from the longitudinal study and linked to Swedish national registers to get information on healthcare resource use. A cost-utility framework was used to evaluate the cost-effectiveness of PBT vs. CRT. Patients in PBT group (n = 310) were matched with patients in CRT group (n = 40) on relevant observables using propensity score matching with replacement. Costs were estimated from a healthcare perspective and included costs related to inpatient and specialized outpatient care, and prescribed medications. The health outcome was quality-adjusted life-years (QALYs), derived from the EORTC-QLQ-C30. Generalized linear models (GLM) and two-part models were used to estimate differences in costs and QALYs.

Results
PBT yielded higher total costs, 14,639 US$, than CRT, 13,308 US$, with a difference of 1,372 US$ (95% CI, -4,914–7,659) over a 58 weeks’ time horizon. Further, PBT resulted in non-significantly lower QALYs, 0.746 compared to CRT, 0.774, with a difference of -0.049 (95% CI, -0.195–0.097). The probability of PBT being cost-effective was < 30% at any willingness to pay.

Conclusions
These results suggest that PBT cannot be considered a cost-effective treatment for brain tumours, compared to CRT.

Trial registration
Not applicable.