bluuebunny/crossref_metadata_2025_split huggingface dataset:
Canadian Treatment Guidelines on Psychosocial Treatment of Schizophrenia in Adults
Authors: Norman Ross , Lecomte Tania , Addington Donald , Anderson Elizabeth 
Published: September 2017

Objective: It is generally recognised that psychosocial interventions are essential components of the effective treatment of schizophrenia in adults. A considerable body of research is being published regarding the effectiveness of such interventions. In the current article, we derive recommendations reflecting the current state of evidence for their effectiveness. Methods: Recommendations were formulated on the basis of a review of relevant guidelines, particularly those formulated by the Scottish Intercollegiate Guideline Network (SIGN) and National Institute for Health and Care Excellence (NICE). Results: There is evidence strongly supporting the use of family interventions, supported employment programs, and cognitive-behavioural therapy. There are also reasons to recommend the use of cognitive remediation, social skills training, and life skills training under specified circumstances. It is important that all patients and families be provided with education about the nature of schizophrenia and its treatment. Several recent innovative psychosocial approaches to treatment are awaiting more thorough evaluation. Conclusions: There continues to be strong evidence for the effectiveness of several psychosocial interventions in improving outcomes for adults with schizophrenia. In the past decade, innovative interventions have been described, several of which are the subject of ongoing evaluative research.
Canadian Practice Guidelines for Comprehensive Community Treatment for Schizophrenia and Schizophrenia Spectrum Disorders
Authors: Addington Donald , Anderson Elizabeth , Kelly Martina , Lesage Alain , Summerville Chris 
Published: September 2017

Objective: The objective of this review is to identify the features and components of a comprehensive system of services for people living with schizophrenia. A comprehensive system was conceived as one that served the full range of people with schizophrenia and was designed with consideration of the incidence and prevalence of schizophrenia. The system should provide access to the full range of evidence-based services, should be recovery oriented, and should provide patient-centred care. Method: A systematic search was conducted for published guidelines for schizophrenia and schizophrenia spectrum disorders. The guidelines were rated by at least 2 raters, and recommendations adopted were primarily drawn from the National Institute for Clinical Excellence (2014) Guideline on Psychosis and Schizophrenia in adults and the Scottish Intercollegiate Guidelines Network guidelines on management of schizophrenia. Results: The recommendations adapted for Canada cover the range of services required to provide comprehensive services. Conclusions: Comprehensive services for people with schizophrenia can be organized and delivered to improve the quality of life of people with schizophrenia and their carers. The services need to be organized in a system that provides access to those who need them.
Canadian Schizophrenia Guidelines: Schizophrenia and Other Psychotic Disorders with Coexisting Substance Use Disorders
Authors: Crockford David , Addington Donald 
Published: September 2017

Objective: Persons with schizophrenia and other psychotic disorders frequently have coexisting substance use disorders that require modifications to treatment approaches for best outcomes. The objectives of this review were to identify evidence-based practices best practices that improve outcomes for individuals with schizophrenia and substance used disorders. Method: We reviewed guidelines that were published in the last 5 years and that included systematic reviews or meta-analyses. Most of our recommendations came from 2 publications from the National Institute for Health and Care Excellence (NICE): the 2011 guidance titled Coexisting Severe Mental Illness (Psychosis) and Substance Misuse: Assessment and Management in Healthcare Settings and the 2014 guidance titled Psychosis and Schizophrenia in Adults: Prevention and Management. We placed these recommendations into the Canadian context to create this guideline. Results: Evidence supports the inclusion of individuals with coexisting substance use disorders in first-episode psychosis programs. The programs should integrate psychosis and substance use treatments, emphasizing ongoing monitoring of both substance use and patterns and symptoms. The best outcomes are achieved with combined use of antipsychotic medications and addiction-based psychosocial interventions. However, limited evidence is available to recommend using one antipsychotic medication over another or one psychosocial intervention over another for persons with schizophrenia and other psychotic disorders with coexisting substance use disorders. Conclusions: Treating persons who have schizophrenia and other psychotic disorders with coexisting substance use disorders can present clinical challenges, but modifications in practice can help engage and retain people in treatment, where significant improvements over time can be expected.
Guidelines for the Pharmacotherapy of Schizophrenia in Adults
Authors: Remington Gary , Addington Donald , Honer William , Ismail Zahinoor , Raedler Thomas , Teehan Michael 
Published: September 2017

Objective:The present guidelines address the pharmacotherapy of schizophrenia in adults across different stages, phases, and symptom domains.Method:Guidelines were developed using the ADAPTE process, which takes advantage of existing guidelines. Six guidelines were identified for adaptation, with recommendations extracted from each. For those specific to the pharmacotherapy of schizophrenia in adults, a working group selected between guidelines and recommendations to create an adapted guideline.Results:Recommendations can be categorized into 6 areas that include 1) first-episode schizophrenia, 2) acute exacerbation, 3) relapse prevention and maintenance treatment, 4) treatment-resistant schizophrenia, 5) clozapine-resistant schizophrenia, and 6) specific symptom domains. For each category, recommendations are made based on the available evidence, which is discussed and linked to other established guidelines.Conclusions:In most cases, evidence-based recommendations are made that can be used to guide current clinical treatment and decision making. Notably, however, there is a paucity of established evidence to guide treatment decision making in the case of clozapine-resistant schizophrenia, a subsample that represents a sizable proportion of those with schizophrenia.
Mid-Sole Release of the Plantar Fascia Combined With Percutaneous Drilling of the Calcaneus for Treatment of Resistant Heel Pain
Authors: Rizk Ahmed Shawkat , Kandel Wael A. , Tabl Eslam Abd Elshafi , Kandil Mahmoud I. 
Published: September 2017

Background: Heel pain with or without calcaneal spur is a challenging problem. Once conservative measures have failed, surgery may be indicated; there has been debate about the best surgical procedure. Two standard operative procedures have been either releasing the plantar fascia or removing the spur with drilling of the calcaneus. In this study, we evaluated the results of percutaneous drilling of the calcaneus combined with mid-sole release of the plantar fascia for treatment of resistant heel pain. Methods: This study included 20 cases with resistant heel pain after failure of conservative measures for 6 months. Clinical, radiological evaluation and scoring patients’ conditions according to the American Orthopaedic Foot & Ankle Society (AOFAS) Ankle-Hindfoot scale was done preoperatively and postoperatively. Percutaneous drilling of the calcaneus combined with mid-sole release of the plantar fascia was done in all cases, and the functional results were evaluated through the follow-up period that extended from 9 to 16 months with a mean duration of 12 ± 2.3 months. Results: There was statistically significant improvement in the mean AOFAS Ankle-Hindfoot scale score from 50.8 ± 7.5 preoperatively to 91.6 ± 7 postoperatively at the last follow-up. There were no surgery-related complications, and the mean time for full recovery was 8 ± 3.7 weeks with no recurrence of pain by the last follow-up. Conclusions: The results were very satisfactory with using this minimally invasive and simple technique for treatment for resistant heel pain. Level of Evidence: Level IV, retrospective case series.
Gastrocnemius Contracture in Patients With Rheumatoid Arthritis
Authors: Jastifer James R. , Green Adam 
Published: September 2017

Background: Rheumatoid arthritis is a chronic disease affecting multiple joints of the body. More than 90% of patients affected by rheumatoid arthritis develop foot or ankle pain over the course of their disease. The purpose of the current study was to report ankle dorsiflexion in rheumatoid arthritis patients as well as a control group utilizing a validated measurement instrument. Methods: Using a previously validated device, 70 patients presenting with rheumatoid arthritis and 70 controls were measured for ankle range motion and isolated gastrocnemius contractures. Clinical and goniometer measurement of ankle range of motion was also performed. Results: The rheumatoid arthritis group had a mean dorsiflexion of 12.3 degrees compared to a mean of 17.3 degrees in the control group ( P < .05). The difference in dorsiflexion was significantly less utilizing a goniometer than using the validated device, which may be due to measurement technique and external landmarks ( P < .05). Conclusion: Patients with rheumatoid arthritis had less ankle dorsiflexion than the control group. The clinical significance of this study is that it provides evidence that patients with rheumatoid arthritis have decreased ankle dorsiflexion even despite a lack of foot and ankle pain. In light of the high lifetime incidence of foot and ankle pain in these patients, this study provides some evidence that the decreased ankle dorsiflexion may be a contributing factor in foot and ankle pain, but further studies are needed. Level of Evidence: Level II, prospective cohort study.
The diagnostic accuracy of 1.5T magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries
Authors: Wade Ryckie G. , Itte Vinay , Rankine James J. , Ridgway John P. , Bourke Grainne 
Published: September 2017

Identification of root avulsions is of critical importance in traumatic brachial plexus injuries because it alters the reconstruction and prognosis. Pre-operative magnetic resonance imaging is gaining popularity, but there is limited and conflicting data on its diagnostic accuracy for root avulsion. This cohort study describes consecutive patients requiring brachial plexus exploration following trauma between 2008 and 2016. The index test was magnetic resonance imaging at 1.5 Tesla and the reference test was operative exploration of the supraclavicular plexus. Complete data from 29 males was available. The diagnostic accuracy of magnetic resonance imaging for root avulsion(s) of C5-T1 was 79%. The diagnostic accuracy of a pseudomeningocoele as a surrogate marker of root avulsion(s) of C5-T1 was 68%. We conclude that pseudomeningocoles were not a reliable sign of root avulsion and magnetic resonance imaging has modest diagnostic accuracy for root avulsions in the context of adult traumatic brachial plexus injuries. Level of evidence: III
The calendar of cytokines: Seasonal variation of circulating cytokines in chronic venous insufficiency
Authors: Spath Paolo , Tisato Veronica , Gianesini Sergio , Tessari Mirko , Menegatti Erica , Manfredini Roberto , Occhionorelli Savino , Secchiero Paola , Zamboni Paolo 
Published: September 2017

Objectives To assess if in chronic venous insufficiency, there is a seasonal variation of cytokines levels which could explain the typical worsening of symptoms during Spring and Summer. Participants From 193 chronic venous insufficiency patients, we selected 32 patients in clinical stage C2–C3 of the Clinical–Etiology–Anatomy–Pathophysiology classification. Design A prospective, comparative and blinded cytokines assessment in two different seasons. Setting We sorted patients by two homogenous groups, 17 Autumn Group and 15 Spring Group. A complete clinical and haemodynamic assessment and laboratory analysis of 22 circulating cytokines were performed on each patient. Main outcome measures Circulating cytokines levels assessment. Results The two groups resulted homogenous for age, gender, clinical class, and haemodynamic parameters. Comparing cytokines expressions in Autumn Group vs. Spring Group, we found a significant difference of 11 out of 22 circulating cytokines (p < 0.05). Particularly Eotaxin, Interleukin-8, Monocyte Chemoattractant Protein-1, Tumour Necrosis Factor-α and Vascular Endothelial Growth Factor were increased in Autumn compared to the Control Group (p < 0.001); while significantly reduced in Spring, within the normal range (p, not significant). Conclusions Symptoms of chronic venous insufficiency are self-reported by patients more intense during warm seasons. Surprisingly, in our study, cytokines levels were significantly higher during Autumn and downregulated in Spring. These variations show for the first time the presence of a ‘Calendar of Cytokines’ in chronic venous insufficiency, which needs to be further investigated.
Leószilárdite, the first Na,Mg-containing uranyl carbonate from the Markey Mine, San Juan County, Utah, USA
Authors: Olds Travis A. , Sadergaski Luke R. , Plášil Jakub , Kampf Anthony R. , Burns Peter C. , Steele Ian M. , Marty Joe , Carlson Shawn M. , Mills Owen P. 
Published: September 2017

AbstractLeószilárdite (IMA2015-128), Na6Mg(UO2)2(CO3)6·6H2O, was found in the Markey Mine, Red Canyon, White Canyon District, San Juan County, Utah, USA, in areas with abundant andersonite, natrozippeite, gypsum, anhydrite, and probable hydromagnesite along with other secondary uranium minerals bayleyite, čejkaite and johannite. The new mineral occurs as aggregates of pale yellow bladed crystals flattened on ﹛001﹜ and elongated along [010], individually reaching up to 0.2 mmlong. More commonly it occurs as pale yellow pearlescent masses to 2 mm consisting of very small plates. Leószilárdite fluoresces green under both longwave and shortwave ultraviolet light, and is translucent with a white streak, hardness of 2 (Mohs), and brittle tenacity with uneven fracture. The new mineral is readily soluble in room temperature H2O. Crystals have perfect cleavage along ﹛001﹜, and exhibit the forms ﹛110﹜,﹛001﹜,﹛100﹜,﹛101﹜ and ﹛101﹜. Optically, leószilárdite is biaxial (-), α= 1.504(1), β= 1.597(1), γ= 1.628(1) (white light); 2V (meas.) = 57(1)°, 2V (calc.) = 57.1°; dispersion r > v, slight. Pleochroism: X= colourless, Y and Z= light yellow; X<Y ≈ Z The average of six wavelength dispersive spectroscopic analyses provided Na2O 14.54, MgO 3.05, UO3 47.95, CO2 22.13, H2O 9.51, total 97.18 wt.%. The empirical formula is Na5.60Mg0.90U2O28C6H12.60, based on 28 O apfu. Leószilárdite is monoclinic, C2/m, a = 11.6093(21), b = 6.7843(13), c = 15.1058(28) Å, β = 91.378(3)°, V= 1189.4(4) Å3 and Z = 2. The crystal structure (R1 = 0.0387 for 1394 reflections with Iobs > 4σI), consists of uranyl tricarbonate anion clusters [(UO2)(CO3)3]4- held together in part by irregular chains of NaO5(H2O) polyhedra sub parallel to [010]. Individual uranyl tricarbonate clusters are also linked together by three-octahedron units consisting of two Na-centred octahedra that share the opposite faces of a Mg-centred octahedron at the centre (Na–Mg–Na), and have the composition Na2MgO12(H2O)4. The name of the new mineral honours the Hungarian-American physicist, inventor and biologist Dr. Leó Szilárd (1898–1964).
Crystal chemistry of zinc incorporation in strunzite-group minerals containing zeolitic water
Authors: Grey I. E. , Keck E. , MacRae C. M. , Glenn A. M. , Kampf A. R. , Nash B. P. , Mills S. J. 
Published: September 2017

AbstractA comparative study is presented of the chemistry and crystallography of zinc-bearing strunzites from Hagendorf Süd, Bavaria, Germany and the Sitio do Castelo mine, Folgosinho, Portugal. Electron microprobe analyses of samples from the two localities show quite different cation substitutions. The Hagendorf Süd mineral is a Zn-bearing ferristrunzite, with compositional zoning due to Zn2+replacing predominantly Fe3+as well as minor Mn2+, whereas the Portugese mineral is a Zn-bearing strunzite, in which Zn2+replaces Mn2+, with minor replacement of Fe3+by Mn3+. Zincostrunzite, with dominant Zn in the interlayer octahedrally coordinated site, is a new strunzite-group mineral that has been characterized at both locations. Analysis of single-crystal synchrotron data for zinc-bearing ferristrunzite and zincostrunzite crystals from Hagendorf Süd show that the structures of both minerals contain zeolitic water in the interlayer region. The formula for strunzite-group minerals containing the zeolitic water isMFe23+(PO4)2(OH)2·6.5H2O, M=Fe, Mn, Zn. This formulation agrees with that found for zincostrunzite from the Sitio do Castelo mine, but differs from that reported previously for strunzite,MFe2+(PO4)2(OH)2·6H2O, which has no interlayer water. Interestingly, the zincostrunzites from the two localities differ in the location of the interlayer water molecule, with a corresponding difference in the H bonding.
Dzierżanowskite, CaCu2S2 – a new natural thiocuprate from Jabel Harmun, Judean Desert, Palestine Autonomy, Israel
Authors: Galuskina Irina O. , Galuskin Evgeny V. , Prusik Krystian , Vapnik Yevgeny , Juroszek Rafał , Jeżak Lidia , Murashko Mikhail 
Published: September 2017

AbstractDzierżanowskite, , a thiocuprate, was found in larnite pseudoconglomerate rocks of the Hatrurim Complex at Jabel Harmun, Palestinian Autonomy, Israel. Dzierżanowskite occurs in larnite pebbles, which are embedded in a low-temperature mineral matrix. Associated minerals are larnite, brownmillerite, fluorellestadite, ye'elimite, gehlenite, periclase, ternesite, nabimusaite, vorlanite, vapnikite, fluormayenite, fluorkyuygenite, oldhamite, jasmundite, covellite, chalcocite and pyrrhotite. Electron microprobe analyses yield an average composition of Cu 55.25, Fe 0.13, S 27.46 and Ca 16.99, total 99.83 wt.%. The empirical formula of dzierżanowskite, based on 5 atoms, is Ca0.98Cu2.02Fe0.01S1.99. Dzierżanowskite forms grains up to 15 μm in size or rims on oldhamite and laminar intergrowths with chalcocite and covellite. Dzierżanowskite is dark orange, has a cream streak and a submetallic lustre. In reflected light it is grey, with a cream tint and characteristic yellow-orange internal reflections. The calculated density of dzierżanowskite is 4.391 g cm -3. Three bands at 300, 103 and 86 cm -1 are observed in the Raman spectrum. The strongest lines of the calculated powder diffraction pattern are [d, Å (I) hkl]: 2.358(100) 102, 1.970(93)110, 3.023(78) 011, 6.523(36) 001, 3.412 (28) 100, 1.834(28) 103. Dzierżanowskite was also found in unusual jasmundite rocks, forming small ‘paleofumaroles’ within areas of low-temperature hydrothermal rocks bearing larnite pseudoconglomerates at Jabel Harmun. Dzierżanowskite is a superimposed phase of the high-temperature alteration of pyrometamorphic rocks subjected to by-products (melts/fluids and gases) of pyrometamorphism originating in the deeper levels of combustion.
Complex exsolution microstructures in ilmenite–pyrophanite from the Garnet Codera dyke pegmatite (Central Italian Alps): an electron microscopy investigation
Authors: Capitani Gian Carlo 
Published: September 2017

AbstractIlmenite–pyrophanite crystals from a garnet pegmatite dyke from the Upper Codera Valley (Sondrio, Italian Alps) showing exsolutions of titanohematite and columbite-tantalite were investigated by scanning and transmission electron microscopy. The titanohematite precipitates share the same crystallographic orientation of the ilmenite-pyrophanite host, are bean-shaped when observed on sections inclined to the pinacoidal section, and are elongated when observed on sections closer to the prism section, possibly because of their discoidal shape parallel to (001). The columbite-tantalite precipitates form a hexagonal network of needles elongated along ⟨110⟩ of the ilmenite–pyrophanite and titanohematite host. The following crystallographic relationship was established: [100]Col//[001]Ilm; [001]Col//(110)Ilm; , which can be explained in terms of preservation of the oxygen close packing between the ilmenite and columbite structures. The interfaces between any two of the three different phases are coherent but show lattice strain contrast and sometimes dislocations because of their different unit-cell dimensions. On the basis of textural observations, titanohematite is supposed to exsolve first, followed by columbite-tantalite at temperatures below 500°C. The addition of MnO to the Fe2O3–FeTiO3 system is supposed to considerably influence the topology of the related T-X phase diagram and the solubility of Nb2O5 and Ta2O5 in this system.
At least 20% donor myeloid chimerism is necessary to reverse the sickle phenotype after allogeneic HSCT
Authors: Fitzhugh Courtney D. , Cordes Stefan , Taylor Tiffani , Coles Wynona , Roskom Katherine , Link Mary , Hsieh Matthew M. , Tisdale John F. 
Published: September 2017

Key PointsResults based on our allogeneic model suggest genetic strategies aimed at correcting at least 20% of HSCs are necessary to reverse SCD. A minority of donor myeloid cells is adequate because of the vast differences in RBC survival between donor and recipient.
Is GDF5 gene promoter polymorphism +104T/C associated with osteoarthritis in the Eastern of Turkey population?
Authors: Tülüce Y. , Yildirim ć°. H. , í–zkol H. , EdiÌ‡z L. , Delen V. 
Published: September 2017

Osteoarthritis (OA) is the most common form of arthritis. Genetic factors have been shown to play important roles in the etiology of OA. The gene growth differentiation factor 5 (GDF5) has been implicated in skeletal development and joint morphogenesis in human and mice. A functional single nucleotide polymorphism (SNP) +104T/C in the 5'-UTR of GDF5 (rs143383) was reported to be associated with osteoarthritis susceptibility in Han Chinese and Japanese populations. Our objective was to assess whether this SNP was also associated with OA in the Eastern Turkey population.A total of 172 cases including 95 patients with idiopathic OA and 77 control cases were recruited into the study. DNA samples were extracted from peripheral blood lymphocytes of all cases by using salting out method. The +104T/C polymorphism was genotyped by PCR-RFLP method. In terms of genotype comparison there wasn't any correlation between patient and control groups. Frequency of C allele was found to be higher in-patient group than control group and statistical analysis showed a poor correlation in allele frequencies of the +104T/C SNP of GDF5 gene between cases and controls (p<0.05). Significant correlation between GDF5 and OA has been reported in Asian population, especially T alleles were found in higher frequencies and related to OA. Our study did not confirm this association and also in term of T allele. Interestingly, we found higher frequency of C allele in patient group than control group and our results are compatible with the study carried out in Greek population.