bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell surface binding, uptaking and anticancer activity of L-K6, a lysine/leucine-rich peptide, on human breast cancer MCF-7 cells
Authors: Wang Che , Dong Shaodan , Zhang Lin , Zhao Ying , Huang Lili , Gong Xiange , Wang He , Shang Dejing 
Published: August 2017

AbstractCell surface binding and internalization are critical for the specific targeting and biofunctions of some cationic antimicrobial peptides (CAPs) with anticancer activities. However, the detailed cellular process for CAPs interacting with cancer cells and the exact molecular basis for their anticancer effects are still far from being fully understood. In the present study, we examined the cell surface binding, uptaking and anti-cancer activity of L-K6, a lysine/leucine-rich CAP, in human MCF-7 breast cancer cells. We found that L-K6 preferentially interact with MCF-7 cells. This tumor-targeting property of L-K6 might be partially due to its interactions with the surface exposed and negatively charged phosphatidylserine. Subsequently, L-K6 could internalize into MCF-7 cells mainly through a clathrin-independent macropinocytosis, without significant cell surface disruption. Finally, the internalized L-K6 induced a dramatic nuclear damage and MCF-7 cell death, without significant cytoskeleton disruption and mitochondrial impairment. This cytotoxicity of L-K6 against MCF-7 cancer cells could be further confirmed by using a mouse xenograft model. In summary, all these findings outlined the cellular process and cytotoxicity of L-K6 in MCF-7 cancer cells, and might help understand the complicated interactions between CAPs and cancer cells.
A Collaborative Model for Return to Academics After Concussion: Athletic Training and Speech-Language Pathology
Authors: Dachtyl Sarah A. , Morales Pedro 
Published: August 2017

PurposeIn this article, we describe an academic concussion management protocol designed for grades Pre-K to 12, called Cognitive Return to Exertion (CoRTEx). Collaboration between the speech-language pathologist (SLP) and athletic trainer (AT) is highlighted.MethodA description of CoRTEx is provided, and the need for collaboration is emphasized. A case study illustrates an example of how CoRTEx can be implemented at the individual student level.ResultsA total of 165 students went through CoRTEx from the pilot in April 2014 through December 2016. Referrals to CoRTEx were highest for football, blows to the head, and soccer. Anecdotal evidence suggests that CoRTEx provided necessary support for students and their families, although research is needed to provide objective data.ConclusionsCoRTEx and other similar protocols can be used as models for SLPs to create their own academic concussion management protocols. For cases in which the injured student is an athlete, the SLP–AT collaboration is critical to carefully coordinate return to academics and return to play so that students are successful in school, as well as ready to safely return to sport. Suggestions are made for designing research studies that can provide empirical evidence for the efficacy of such academic concussion management protocols.
Orbiting a binary
Authors: Bonavita M. , D’Orazi V. , Mesa D. , Fontanive C. , Desidera S. , Messina S. , Daemgen S. , Gratton R. , Vigan A. , Bonnefoy M. , Zurlo A. , Antichi J. , Avenhaus H. , Baruffolo A. , Baudino J. L. , Beuzit J. L. , Boccaletti A. , Bruno P. , Buey T. , Carbillet M. , Cascone E. , Chauvin G. , Claudi R. U. , De Caprio V. , Fantinel D. , Farisato G. , Feldt M. , Galicher R. , Giro E. , Gry C. , Hagelberg J. , Incorvaia S. , Janson M. , Jaquet M. , Lagrange A. M. , Langlois M. , Lannier J. , Le Coroller H. , Lessio L. , Ligi R. , Maire A. L. , Meyer M. , Menard F. , Perrot C. , Peretti S. , Petit C. , Ramos J. , Roux A. , Salasnich B. , Salter G. , Samland M. , Scuderi S. , Schlieder J. , Surez M. , Turatto M. , Weber L. 
Published: August 2017

Aims. In this paper we present the results of the SPHERE observation of the HD 284149 system, aimed at a more detailed characterisation of both the primary and its brown dwarf companion.
Methods. We observed HD 284149 in the near-infrared with SPHERE, using the imaging mode (IRDIS+IFS) and the long-slit spectroscopy mode (IRDIS-LSS). The data were reduced using the dedicated SPHERE pipeline, and algorithms such as PCA and TLOCI were applied to reduce the speckle pattern.
Results. The IFS images revealed a previously unknown low-mass (~0.16 M⊙) stellar companion (HD 294149 B) at ~0.1′′, compatible with previously observed radial velocity differences, as well as proper motion differences between Gaia and Tycho-2 measurements. The known brown dwarf companion (HD 284149 b) is clearly visible in the IRDIS images. This allowed us to refine both its photometry and astrometry. The analysis of the medium resolution IRDIS long slit spectra also allowed a refinement of temperature and spectral type estimates. A full reassessment of the age and distance of the system was also performed, leading to more precise values of both mass and semi-major axis.
Conclusions. As a result of this study, HD 284149 ABb therefore becomes the latest addition to the (short) list of brown dwarfs on wide circumbinary orbits, providing new evidence to support recent claims that object in such configuration occur with a similar frequency to wide companions to single stars.
The Protruding Ear: Cosmetic and Reconstruction
Authors: Ali Kausar , Meaike Jesse , Maricevich Renata , Olshinka Asaf 
Published: August 2017

AbstractEar prominence is a relatively common cosmetic deformity with no associated functional deficits, but with profound psychosocial impact, especially in young patients. Protruding ears in children have propagated surgical advances that incorporate reconstructive techniques. Here we outline a systematic framework to evaluate the protruding ear and present various reconstructive surgical options for correction. Both cosmetic and reconstructive perspectives should be entertained when addressing this anatomical deformity.
Of hopes and plans
Authors: Bös Birte 
Published: August 2017

Abstract
This study investigates a specialised corpus of prefatory metadiscourse, i.e. newsmakers’ comments published in the first editions of their newspapers which appeared on the market at the end of the seventeenth century and in the first decades of the eighteenth century. The material analysed provides insights into contemporary journalistic practices and ideals, the ways newsmakers positioned themselves and projected their audiences. Certain structural similarities, e.g. a recurrent three-step argumentation structure, suggest that newsmakers often resorted to prevalent rhetorical patterns. Yet, the period under investigation also displays some diachronic changes, from a preference for relatively concise, practically oriented comments to more elaborate metadiscursive passages featuring fictional editorial personae and an ornate literary style.
Strengthening of beam - column joint with steel fibre reinforced concrete under seismic loading
Authors: Prasanna K , Ramasubramani R , Anandh K S , Saisabarish  , Maddu Vijay Krupaker 
Published: August 2017

Abstract
Earthquakes not only kill the human beings but the structures too. Considering this above fact, there is a necessity to take care of the beam column joint region in a structure. Under seismic excitation, the bar segment joint district is subjected to even and the vertical shear force extents are normally commonly greater than those in the adjoining bits of the structural segments. In the event that the joint is not precisely nitty gritty, the shaft segment joint may end up plainly frail. To keep this, an adequate control ought to be given in the joint area. The seismic examination and outline technique ought to be utilised as a part of the plan of the building structures and their segments ought to be recommended in the segment. The building structures incorporate finish sidelong and vertical drive opposing frameworks fit for giving satisfactory quality. Stiffness and the vitality dissemination ability to withstand the outline ground movements inside the recommended furthest reaches of twisting and quality request. The plan ground movements are accepted to happen along any even headings of a building structure. This work focuses on behaviour of M20 concrete in beam-column joint subjected to seismic loading, by using steel fibre (1.5%). The specimens detailed as per IS: 456-2000 and IS: 13920-1993 were casted and tested under cyclic and reverse cyclic loading. The parameters analysed were ductility, energy dissipation, load v/s displacement curve, beam-column reinforcement strain and crack pattern. From the experimental investigation, it is found that the fibre reinforced beam-column joint with fibre (1.50% of steel fibre) performs better ductility, load carrying capacity, energy dissipation and strength by 10% more than conventional reinforced beam-column joint.
PyLasso: a PyMOL plugin to identify lassos
Authors: Gierut Aleksandra M , Niemyska Wanda , Dabrowski-Tumanski Pawel , Sułkowski Piotr , Sulkowska Joanna I 
Published: August 2017

Abstract

Summary
Entanglement in macromolecules is an important phenomenon and a subject of multidisciplinary research. As recently discovered, around 4% of proteins form new entangled motifs, called lassos. Here we present the PyLasso—a PyMOL plugin to identify and analyse properties of lassos in proteins and other (bio)polymers, as well as in other biological, physical and mathematical systems. The PyLasso is a useful tool for all researchers working on modeling of macromolecules, structure prediction, properties of polymers, entanglement in fluids and fields, etc.

Availability and implementation
The PyLasso and tutorial videos are available at http://pylasso.cent.uw.edu.pl
Conditional asymptotic inference for the kernel association test
Authors: Wang Kai 
Published: August 2017

Abstract

Motivation
The kernel association test (KAT) is popular in biological studies for its ability to combine weak effects potentially of opposite direction. Its P-value is typically assessed via its (unconditional) asymptotic distribution. However, such an asymptotic distribution is known only for continuous traits and for dichotomous traits. Furthermore, the derived P-values are known to be conservative when sample size is small, especially for the important case of dichotomous traits. One alternative is the permutation test, a widely accepted approximation to the exact finite sample conditional inference. But it is time-consuming to use in practice due to stringent significance criteria commonly seen in these analyses.

Results
Based on a previous theoretical result a conditional asymptotic distribution for the KAT is introduced. This distribution provides an alternative approximation to the exact distribution of the KAT. An explicit expression of this distribution is provided from which P-values can be easily computed. This method applies to any type of traits. The usefulness of this approach is demonstrated via extensive simulation studies using real genotype data and an analysis of genetic data from the Ocular Hypertension Treatment Study. Numerical results showed that the new method can control the type I error rate and is a bit conservative when compared to the permutation method. Nevertheless the proposed method may be used as a fast screening method. A time-consuming permutation procedure may be conducted at locations that show signals of association.

Availability and implementation
An implementation of the proposed method is provided in the R package iGasso.
“I Want to Know the Answer! Give Me Fish ’n’ Chips!”: The Impact of Curiosity on Indulgent Choice
Authors: Wang Chen , Huang Yanliu 
Published: August 2017

Abstract
This research examines how incidentally induced consumer curiosity influences subsequent indulgent decisions. Prior research has primarily focused on the effect of curiosity on information seeking in the present domain. The current research goes further to propose that the curiosity effect can spill over to prompt consumers to prefer indulgent options in other, unrelated domains (e.g., food, money). This situation is likely to occur because curiosity motivates individuals to seek the missing information as the specific information reward in the current domain. Such desire to obtain the information reward primes a reward-seeking goal, which in turn leads to increased preferences for indulgent options in subsequent, unrelated domains. Furthermore, the impact of curiosity on indulgent options possesses goal-priming properties as identified by the literature. That is, the effect should (1) persist after a time delay, and (2) diminish when the reward-seeking goal is satiated by the obtainment of a reward before the indulgent task. We conduct a series of studies to provide support for our hypotheses. This research contributes to both curiosity and indulgence decision literature and offers important practical implications.
i-Factor™ Bone Graft vs Autograft in Anterior Cervical Discectomy and Fusion: 2-Year Follow-up of the Randomized Single-Blinded Food and Drug Administration Investigational Device Exemption Study
Authors: Arnold Paul M , Sasso Rick C , Janssen Michael E , Fehlings Michael G , Heary Robert F , Vaccaro Alexander R , Kopjar Branko 
Published: August 2017

Abstract

BACKGROUND
i-Factor™ Bone Graft (Cerapedics Inc, Westminster, Colorado) is a composite bone substitute material consisting of P-15 synthetic collagen fragment adsorbed onto anorganic bone mineral suspended in an inert biocompatible hydrogel carrier. A pivotal, noninferiority, US FDA Investigational Device Exemption study demonstrated the benefits of i-Factor™ compared to local autograft bone in single-level anterior cervical discectomy and fusion at 1-yr postoperative.

OBJECTIVE
To report 2-yr follow-up.

METHODS
Subjects randomly received either autograft (n = 154) or i-Factor™ (n = 165) in a cortical ring allograft and followed using radiological, clinical, and patient-reported outcomes.

RESULTS
At 2 yr, the fusion rate was 97.30% and 94.44% in i-Factor™ and autograft subjects, respectively (P = .2513), and neurological success rate was 94.87% (i-Factor™) and 93.79% (autograft; P = .7869). Neck Disability Index improved 28.30 (i-Factor™) and 26.95 (autograft; P = .1448); Visual Analog Scale arm pain improved 5.43 (i-Factor™) and 4.97 (autograft) (p = .2763); Visual Analog Scale neck pain improved 4.78 (i-Factor™) and 4.41 (autograft; P = .1652), Short Form-36 (SF-36v2) Physical Component Score improved 10.23 (i-Factor™) and 10.18 (autograft; P = .4507), and SF36v2 Mental Component Score improved 7.88 (i-FactorTM) and 7.53 (autograft; P = .9872). The composite endpoint of overall success (fusion, Neck Disability Index improvement >15, neurological success, and absence of re-operations) was greater in i-Factor™ subjects compared to autograft subjects (69.83% and 56.35%, respectively, P = .0302). Twelve (7.45%) i-Factor™ subjects and 16 (10.53%) autograft subjects underwent re-operation (P = .3411). There were no allergic reactions associated with i-Factor™.

CONCLUSION
Use of i-Factor™ in anterior cervical discectomy and fusion is effective and safe, and results in similar outcomes compared to local autograft bone at 2 yr following surgery.
Polyelectrolyte Solutions and Gels
Authors: Dobrynin Andrey V. 
Published: August 2017

Abstract
This article examines the physics of polyelectrolytes, with particular emphasis on the properties of individual charged chains in solution, in more dense environments and in crosslinked gels. Polyelectrolyte solutions and gels are multicomponent systems comprised of solvent molecules, charged polymer chains, counterions, and salt ions. The properties of these systems depend on polymer and salt concentrations, the electrostatic interactions between charges, monomer-solvent interactions controlling the solvent affinity for the polymer backbone, and the interactions between charges and solvent molecules determining solvation of the ions by a solvent. This article first considers dilute salt-free polyelectrolyte solutions, focusing on polyelectrolyte chains, the condensation of counterions, and ionization equilibrium. The discussion then turns to a polyelectrolyte chain in salt solutions, semidilute polyelectrolyte solutions, and phase separation in polyelectrolyte solutions. The article concludes with an analysis of swelling in polyelectrolyte gels.
X-ray upper limits of GW151226 with MAXI
Authors: Serino Motoko , Kawai Nobuyuki , Negoro Hitoshi , Mihara Tatehiro , Masumitsu Takahiro , Nakahira Satoshi 
Published: August 2017

Abstract
The error region of the the gravitational-wave (GW) event GW151226 was observed with Monitor of All-sky X-ray Image (MAXI). MAXI was operating at the time of GW151226, and continuously observed up to 4 min after the event. MAXI covered about 84% of the 90% error region of the GW event during the first 92 min orbit after the event. No significant X-ray transient was detected in the GW error region. A typical 3 σ Gas Slit Camera upper limit for a scan is 1.2 × 10−9 erg cm−2 s−1 in the 2–20 keV band. The autodetection (MAXI nova-search) systems detected a short excess event with a low significance (2.85 σ) from 5257 s to 5260 s after the GW trigger. Finally, we discuss the sensitivity of MAXI to long X-ray emissions of short gamma-ray bursts, which are expected to accompany GW events.
neoantigenR: An annotation based pipeline for tumor neoantigen identification from sequencing data
Authors: Tang Shaojun , Madhavan Subha 
Published: August 2017

AbstractStudies indicate that more than 90% of human genes are alternatively spliced, suggesting the complexity of the transcriptome assembly and analysis. The splicing process is often disrupted, resulting in both functional and non-functional end-products (Sveen et al. 2016) in many cancers. Harnessing the immune system to fight against malignant cancers carrying aberrantly mutated or spliced products is becoming a promising approach to cancer therapy. Advances in immune checkpoint blockade have elicited adaptive immune responses with promising clinical responses to treatments against human malignancies (Tumor Neoantigens in Personalized Cancer Immunotherapy 2017). Emerging data suggest that recognition of patient-specific mutation-associated cancer antigens (i.e. from alternative splicing isoforms) may allow scientists to dissect the immune response in the activity of clinical immunotherapies (Schumacher and Schreiber 2015). The advent of high-throughput sequencing technology has provided a comprehensive view of both splicing aberrations and somatic mutations across a range of human malignancies, allowing for a deeper understanding of the interplay of various disease mechanisms.Meanwhile, studies show that the number of transcript isoforms reported to date may be limited by the short-read sequencing due to the inherit limitation of transcriptome reconstruction algorithms, whereas long-read sequencing is able to significantly improve the detection of alternative splicing variants since there is no need to assemble full-length transcripts from short reads. The analysis of these high-throughput long-read sequencing data may permit a systematic view of tumor specific peptide epitopes (also known as neoantigens) that could serve as targets for immunotherapy (Tumor Neoantigens in Personalized Cancer Immunotherapy 2017).Currently, there is no software pipeline available that can efficiently produce mutation-associated cancer antigens from raw high-throughput sequencing data on patient tumor DNA (The Problem with Neoantigen Prediction 2017). In addressing this issue, we introduce a R package that allows the discoveries of peptide epitope candidates, which are the tumor-specific peptide fragments containing potential functional neoantigens. These peptide epitopes consist of structure variants including insertion, deletions, alternative sequences, and peptides from nonsynonymous mutations. Analysis of these precursor candidates with widely used tools such as netMHC allows for the accurate in-silico prediction of neoantigens. The pipeline named neoantigeR is currently hosted inhttps://github.com/ICBI/neoantigeR.
MEG-BIDS: an extension to the Brain Imaging Data Structure for magnetoencephalography
Authors: Niso Guiomar , Gorgolewski Krzysztof J. , Bock Elizabeth , Brooks Teon L. , Flandin Guillaume , Gramfort Alexandre , Henson Richard N. , Jas Mainak , Litvak Vladimir , Moreau Jeremy , Oostenveld Robert , Schoffelen Jan-Mathijs , Tadel Francois , Wexler Joseph , Baillet Sylvain 
Published: August 2017

AbstractWe present a significant extension of the Brain Imaging Data Structure (BIDS) to support the specific aspects of magnetoencephalography (MEG) data. MEG provides direct measurement of brain activity with millisecond temporal resolution and unique source imaging capabilities. So far, BIDS has provided a solution to structure the organization of magnetic resonance imaging (MRI) data, which nature and acquisition parameters are different. Despite the lack of standard data format for MEG, MEG-BIDS is a principled solution to store, organize and share the typically-large data volumes produced. It builds on BIDS for MRI, and therefore readily yields a multimodal data organization by construction. This is particularly valuable for the anatomical and functional registration of MEG source imaging with MRI. With MEG-BIDS and a growing range of software adopting the standard, the MEG community has a solution to minimize curation overheads, reduce data handling errors and optimize usage of computational resources for analytics. The standard also includes well-defined metadata, to facilitate future data harmonization and sharing efforts.