bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ship space to database: emerging infrastructures for studies of the deep subseafloor biosphere
Authors: Darch Peter T. , Borgman Christine L. 
Published: November 2016

BackgroundAn increasing array of scientific fields face a “data deluge.” However, in many fields data are scarce, with implications for their epistemic status and ability to command funding. Consequently, they often attempt to develop infrastructure for data production, management, curation, and circulation. A component of a knowledge infrastructure may serve one or more scientific domains. Further, a single domain may rely upon multiple infrastructures simultaneously. Studying how domains negotiate building and accessing scarce infrastructural resources that they share with other domains will shed light on how knowledge infrastructures shape science.MethodsWe conducted an eighteen-month, qualitative study of scientists studying the deep subseafloor biosphere, focusing on the Center for Dark Energy Biosphere Investigations (C-DEBI) and the Integrated Ocean Drilling Program (IODP) and its successor, the International Ocean Discovery Program (IODP2). Our methods comprised ethnographic observation, including eight months embedded in a laboratory, interviews (n = 49), and document analysis.ResultsDeep subseafloor biosphere research is an emergent domain. We identified two reasons for the domain’s concern with data scarcity: limited ability to pursue their research objectives, and the epistemic status of their research. Domain researchers adopted complementary strategies to acquire more data. One was to establish C-DEBI as an infrastructure solely for their domain. The second was to use C-DEBI as a means to gain greater access to, and reconfigure, IODP/IODP2 to their advantage. IODP/IODP2 functions as infrastructure for multiple scientific domains, which creates competition for resources. C-DEBI is building its own data management infrastructure, both to acquire more data from IODP and to make better use of data, once acquired.DiscussionTwo themes emerge. One is data scarcity, which can be understood only in relation to a domain’s objectives. To justify support for public funding, domains must demonstrate their utility to questions of societal concern or existential questions about humanity. The deep subseafloor biosphere domain aspires to address these questions in a more statistically intensive manner than is afforded by the data to which it currently has access. The second theme is the politics of knowledge infrastructures. A single scientific domain may build infrastructure for itself and negotiate access to multi-domain infrastructure simultaneously. C-DEBI infrastructure was designed both as a response to scarce IODP/IODP2 resources, and to configure the data allocation processes of IODP/IODP2 in their favor.
Do Emergency Medicine Residents Prefer Resident‐initiated or Attending‐initiated Feedback?
Authors: McGhee Jonathan , Crowe Colleen , Kraut Aaron , Pierce Ava , Porat Avital , Schnapp Benjamin , Laurie Amber , Fu Rongwei , Yarris Lalena 
Published: November 2016

AbstractBackgroundReal‐time feedback is crucial to improving physician performance. Emerging theory suggests that learner‐initiated feedback may be more effective in changing performance than attending‐initiated feedback, but little is known about how residents perceive resident‐ versus attending‐initiated feedback.ObjectivesThe primary aim was to determine whether residents' satisfaction varied by learner‐versus attending‐initiated feedback encounters. We hypothesized that residents would be more satisfied with resident‐initiated feedback.MethodsThis was a multicenter study of five emergency medicine residency programs. We developed a milestones‐based, real‐time feedback intervention that provided behavioral anchors for ED subcompetencies and prompted a feedback discussion. The intervention was implemented at all sites for a 3‐month period from March to November 2014. Residents were asked to initiate one card per shift; attendings were also invited to initiate encounters and, in either instance, asked to provide one specific suggestion for improvement. Residents confidentially rated their satisfaction with feedback on a 10‐point scale. Reported satisfaction was categorized as “very satisfied” (score of 10) versus “less than very satisfied” (score < 10). Logistic regression was used to assess the difference in satisfaction between resident‐ versus attending‐initiated feedback, and random effects were used to account for the clustering of repeated ratings within resident and by site.ResultsA total of 785 cards was collected from five sites. Participation varied by site (range = 21–487 cards per site). Of the 587 cards with both feedback initiator and satisfaction data, 67% (396/587) were resident‐initiated, and median satisfaction score was 10 (range = 4–10). There was no difference in the odds of being “very satisfied” by resident‐ vesus attending‐initiated encounters (odds ratio = 1.08, 95% confidence interval = 0.41 to 2.83).ConclusionsOur results suggest that residents are likely to be as satisfied with self‐initiated feedback as attending‐initiated feedback. Further research is needed to determine whether resident‐initiated feedback is more likely to be incorporated into practice and result in objective performance improvements.
Electrodeposition of insulating poly(phenylene oxide) films with variable thickness
Authors: Timmermans Marina Y. , Mattelaer Felix , Moitzheim Sébastien , Clerckx Nick , Sepulveda Alfonso , Deheryan Stella , Detavernier Christophe , Vereecken Philippe M. 
Published: November 2016

ABSTRACTAbility to control key characteristics of electrodeposited polymers plays a vital role for their applications. In this work the results on tailoring the thickness of electronically insulating poly(phenylene oxide) (PPO) type polymer films have been showed. Pinhole‐free PPO films with variable thickness in the range of 10–50 nm were grown by controlling the potential applied during the electrochemical polymerization on the surface of titanium nitride (TiN) substrates. The insulating properties of the PPO film were confirmed by testing its permeability to redox species by cyclic voltammetry. Thermal stability of the PPO films with different thicknesses was investigated by in‐situ spectroscopic ellipsometry up to 400 °C in various environments. This insight is important for the optimization of the PPO anneal conditions in order to remove the residual solvent and potentially improve the polymer chains stacking. Our results provide the basis for electrodeposition of PPO films with variable thickness for diverse applications. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44533.
An inflammatory biomarker‐based nomogram to predict prognosis of patients with nasopharyngeal carcinoma: an analysis of a prospective study
Authors: Li Xiao‐Hui , Chang Hui , Xu Bing‐Qing , Tao Ya‐Lan , Gao Jin , Chen Chen , Qu Chen , Zhou Shu , Liu Song‐Ran , Wang Xiao‐Hui , Zhang Wen‐Wen , Yang Xin , Zhou Si‐Lang , Xia Yun‐Fei 
Published: November 2016

AbstractChronic inflammation plays an important role in tumor progression. The aim of this analysis was to evaluate whether inflammatory biomarkers such as the Glasgow prognostic score (GPS), the neutrophil‐lymphocyte ratio (NLR), the platelet‐lymphocyte ratio (PLR), and the lymphocyte‐monocyte ratio (LMR) could predict the prognosis of nasopharyngeal carcinoma (NPC). In this analysis, pretreatment GPS, NLR, PLR, LMR of 388 patients who were diagnosed as nonmetastatic NPC and recruited prospectively in the 863 Program No. 2006AA02Z4B4 were assessed. Of those, the 249 cases enrolled between December 27th 2006 and July 31st 2011 were defined as the development set. The rest 139 cases enrolled between August 1st 2011 and July 31st 2013 were defined as the validation set. The variables above were analyzed in the development set, together with age, gender, Karnofsky performance score, T stage, and N stage, with respect to their impact on the disease‐specific survival (DSS) through a univariate analysis. The candidate prognostic factors then underwent a multivariate analysis. A nomogram was established to predict the DSS, by involving the independent prognostic factors. Its predction capacity was evaluated through calculating Harrell's concordance index (C‐index) in the validation set. After multivariate analysis for the development set, age (≤50 vs. >50 years old), T stage (T1–2 vs. T3–4), N stage (N0–1 vs. N2–3) and pretreatment GPS (0 vs. 1–2), NLR (≤2.5 vs. >2.5), LMR (≤2.35 vs. >2.35) were independent prognostic factors of DSS (P values were 0.002, 0.008, <0.001, 0.004, 0.018, and 0.004, respectively). A nomogram was established by involving all the factors above. Its C‐index for predicting the DSS of the validation set was 0.734 (standard error 0.056). Pretreatment GPS, NLR, and LMR were independent prognostic factors of NPC. The nomogram based on them could be used to predict the DSS of NPC patients.
ChemInform Abstract: Single Crystal Growth of CeTAl3 (T: Cu, Ag, Au, Pd and Pt).
Authors: Franz C. , et al.  
Published: November 2016

AbstractSingle crystals of the title series are grown by optical float zoning of polycrystalline samples prepared from CeAl2 and the Pt‐group metals (5 mm/h growth rate, 6 rpm counter‐rotation of polycrystalline feed and seed rod).
ChemInform Abstract: Anion Ordering, Magnetic Structure and Properties of the Vacancy Ordered Perovskite Ba3Fe3O7F.
Authors: Clemens Oliver , Reitz Christian , Witte Ralf , Kruk Robert , Smith Ronald I. 
Published: November 2016

AbstractPerovskite‐type Ba3Fe3O7F is prepared by heating stoichiometric amounts of Ba2Fe2O5 and polyvinylidene difluoride in air (370 °C, 12 h) and subsequent heating under argon (450 °C, 24 h).
ChemInform Abstract: Soft Magnetic ε‐Fe3N: Synthesis, Characterization and Magnetic Properties.
Authors: Yin Wenxu , Zhang Daguang , Zhang Peng , Wang Xiaobai , Wang Wei , Lei Xiang , Shi Zhan , Yang Hua 
Published: November 2016

AbstractBlack polycrystalline ε‐Fe3N is precipitated from an anhydrous solution of FeCl3 in acetone to which different amounts of en are added as the nitrogen source prior to a calcination under N2 (560 °C, 30 min).
ChemInform Abstract: Zig‐Zag Magnetic Ordering in Honeycomb‐Layered Na3Co2SbO6.
Authors: Wong Cheryl , Avdeev Maxim , Ling Chris D. 
Published: November 2016

AbstractNa3Co2SbO6 is prepared by calcination of stoichiometric amounts of Na2CO3, Co3O4, and Sb2O3 in air (1.
ChemInform Abstract: Experimental Investigation of the Phase Diagram of the Fe‐Pd‐Nd Ternary System at 773 K.
Authors: Du Y.s. , Li C. R. , Cheng G. , Sun Y. Z. , Wu X. F. , Yao Q. R. 
Published: November 2016

AbstractThe 773 K isothermal section of the title system is investigated by XRD, SEM, DSC, and EDS techniques.
ChemInform Abstract: Synthesis, Crystal Structure, and Ionic Conductivity of a New Layered Metal Phosphate, Li2Sr2Al(PO4)3.
Authors: Kim Sung‐Chul , Kwak Hyun‐Jung , Yoo Chung‐Yul , Yun Hoseop , Kim Seung‐Joo 
Published: November 2016

AbstractSingle crystals of the title compound are grown from a molten hydroxide flux containing SrCO3, Al2O3, NH4H2PO4, and LiOH in the molar ratio of 2:0.5:3:100 (Ag tube, 1103 K, 24 h).
ChemInform Abstract: A Ta/W Mixed Addenda Heteropolyacid with Excellent Acid Catalytic Activity and Proton‐Conducting Property
Authors: Li Shujun , Peng Qingpo , Chen Xuenian , Wang Ruoya , Zhai Jianxin , Hu Weihua , Ma Fengji , Zhang Jie , Liu Shuxia 
Published: November 2016

AbstractH20 [P8W60Ta12(H2O)4 (OH)8O236]·125H2O (H‐1) is prepared by passing an aqueous solution of the precursor K8Na8H4 [P8W60Ta12(H2O)4 (OH)8O236]·42H2O through an acidified ion exchange resin and subsequent solvent evaporation (94.7% yield).
ChemInform Abstract: {[CuSn5Sb3]2‐}2: A Dimer of Inhomogeneous Superatoms.
Authors: Wilson Robert J. , Broeckaert Lies , Spitzer Fabian , Weigend Florian , Dehnen Stefanie 
Published: November 2016

AbstractCrystals of [K([2.2.2]crypt)]4 [CuSn5Sb3]2·3en (I) and [K([2.2.2]crypt)]4 [CuSn5Sb3]2·2toluene (II) are obtained in the reaction of equimolar amounts [K([2.2.2]crypt)]2[Sn2Sb2]·en (III) and the β‐diketiminato complex [LCu(MeCN)] (L: [(N(C6H3iPr2‐2,6)C(Me))2CH] ‐) in en or DMF (3 h; layering with toluene, 5 °C, 10—14 d).
ChemInform Abstract: Quaternary Germanides RE3TRh4Ge4 (RE: Ce, Pr, Nd; T: Nb, Ta) — A New Coloring Variant of the Aristotype AlB2.
Authors: Hoffmann Rolf‐Dieter , Vosswinkel Daniel , Matar Samir F. , Poettgen Rainer 
Published: November 2016

AbstractThe title compounds are prepared from the elements by arc‐melting and subsequent annealing (1400 K, 14 d).
ChemInform Abstract: Rhodium‐Catalyzed Asymmetric Arylation of N‐ and O‐Containing Cyclic Aldimines: Facile and Efficient Access to Highly Optically Active 3,4‐Dihydrobenzo[1,4]oxazin‐2‐ones and Dihydroquinoxalinones.
Authors: Zhang Xu , Xu Bin , Xu Ming‐Hua 
Published: November 2016

AbstractFor the first time, a highly enantioselective rhodium‐catalyzed arylation of benzoxazinones and quinoxalinones is realized by employing an unsaturated chiral sulfoxide ligand.
ChemInform Abstract: Radical Beckmann Rearrangement and Its Application in the Formal Total Synthesis of Antimalarial Natural Product Isocryptolepine via C—H Activation.
Authors: Mahajan Pankaj S. , Humne Vivek T. , Tanpure Subhash D. , Mhaske Santosh B. 
Published: November 2016

AbstractThe Beckmann rearrangement of ketoximes is mediated by ammonium persulfate‐dimethyl sulfoxide as a reagent under neutral conditions.
ChemInform Abstract: A Practicable Synthesis of Oxazol‐5(4H)‐ones Through Hydrogenation: Scope and Applications.
Authors: Pinheiro Danielle L. J. , Avila Eloah P. , Amarante Giovanni W. 
Published: November 2016

AbstractA hydrogenation of arylidene oxazolones using Pd‐C as catalyst is presented.
ChemInform Abstract: B(C6F5)3‐Catalyzed Reduction of Aromatic and Aliphatic Nitro Groups with Hydrosilanes.
Authors: Porwal Digvijay , Oestreich Martin 
Published: November 2016

AbstractA transition‐metal‐free, B(C6F5)3‐catalyzed deoxygenation of aromatic and aliphatic nitro compounds by Et3SiH affords the corresponding amines.
ChemInform Abstract: A Zinc‐Catalyzed Oxidative Reaction of Ynamides with Phenols and Thiophenols: Highly Site‐Selective Synthesis of Versatile α‐Aryloxy Amides and α‐Arylthio Amides.
Authors: Ruan Peng‐Peng , Shen Cang‐Hai , Li Long , Liu Chao‐Yue , Ye Long‐Wu 
Published: November 2016

AbstractA novel zinc‐catalyzed oxidative reaction of ynamides with phenols, thiophenols, and anilines allows the access to various α‐substituted amides.
ChemInform Abstract: Regioselective Organocatalytic Formation of Carbamates from Substituted Cyclic Carbonates.
Authors: Sopena Sergio , Laserna Victor , Guo Wusheng , Martin Eddy , Escudero‐Adan Eduardo C. , Kleij Arjan W. 
Published: November 2016

AbstractA broad spectrum of substituted carbonate substrates is subjected to aminolysis in the presence of TBD.
ChemInform Abstract: New Access to Quaternary Aminocyclobutanes via Nucleophilic Addition on Cyclobutaniminium Salts.
Authors: Kolleth Amandine , Lumbroso Alexandre , Tanriver Gamze , Catak Saron , Sulzer‐Mosse Sarah , De Mesmaeker Alain 
Published: November 2016

Abstractgenerated in situ from N,N‐disubstituted amides of cyclobutanoic or phenylacetic acids and alkenes
ChemInform Abstract: Anthranil: An Aminating Reagent Leading to Bifunctionality for Both C(sp3)—H and C(sp2)—H under Rhodium(III) Catalysis.
Authors: Yu Songjie , Tang Guodong , Li Yingzi , Zhou Xukai , Lan Yu , Li Xingwei 
Published: November 2016

AbstractAnthranil is designed as novel bifunctional aminating reagent for both C(sp2)—H and C(sp3)—H bonds under rhodium(III) catalysis, thus affording a nucleophilic aniline tethered to an electrophilic carbonyl.
ChemInform Abstract: From a Sequential to a Concurrent Reaction in Aqueous Medium: Ruthenium‐Catalyzed Allylic Alcohol Isomerization and Asymmetric Bioreduction.
Authors: Rios‐Lombardia Nicolas , Vidal Cristian , Liardo Elisa , Moris Francisco , Garcia‐Alvarez Joaquin , Gonzalez‐Sabin Javier 
Published: November 2016

AbstractThe ruthenium‐catalyzed redox isomerization of allylic alcohols is successfully coupled with the enantioselective enzymatic ketone reduction (mediated by KREDs) in a concurrent process in aqueous medium.
ChemInform Abstract: Biomass‐Derived γ‐Valerolactone as an Efficient Solvent and Catalyst for the Transformation of CO2 to Formamides.
Authors: Song Jinliang , Zhou Baowen , Liu Huizhen , Xie Chao , Meng Qinglei , Zhang Zhanrong , Han Buxing 
Published: November 2016

AbstractA biomass‐derived γ‐valerolactone acts as the solvent and catalyst for transformation of CO2 with various primary and secondary amines in the presence of phenylsilane (PhSiH3).
ChemInform Abstract: Synthesis of β‐Ketosulfones by Using Sulfonyl Chloride as a Sulfur Source.
Authors: Xia Yingya , Chen Xiaolan , Qu Lingbo , Sun Kai , Xia Xiaoyi , Fu Wenkai , Chen Xi , Yang Yongkang , Zhao Yufen , Li Chaojun 
Published: November 2016

AbstractUsing tert‐butyl hydroperoxide as the oxidant, alkyl/aryl‐sulfonyl chlorides (I) react with vinyl(het)arenes (II) and (IV) to the corresponding (het)aryloylmethyl alkyl/aryl sulfones.
ChemInform Abstract: Silver(I)‐Catalyzed Three‐Component Reaction of Propargylic Alcohols, Carbon Dioxide and Monohydric Alcohols: Thermodynamically Feasible Access to β‐Oxopropyl Carbonates.
Authors: Zhou Zhi‐Hua , Song Qing‐Wen , Xie Jia‐Ning , Ma Ran , He Liang‐Nian 
Published: November 2016

AbstractThe procedure affords various title compounds in mostly high yields, if terminal propargylic alcohols are used.
ChemInform Abstract: Palladium Catalyzed Desulfinylative Couplings Between Aryl Sulfinates and Aryl Bromide/Iodide for the Synthesis of Biaryls.
Authors: Gund Sitaram Haribhau , Balsane Kishor Eknath , Nagarkar Jayashree Milind 
Published: November 2016

AbstractThe protocol has a broad substrate scope.
ChemInform Abstract: Enantioselective Construction of Novel Chiral Spirooxindoles Incorporating a Thiazole Nucleus.
Authors: Cui L.‐Y. , Wang Y.‐M. , Zhou Z.‐H. 
Published: November 2016

AbstractUsing a series of chiral bifunctional hydrogen‐bonding organocatalysts, the asymmetric cascade Michael/cyclization reaction between 2‐substituted thiazolones and 2‐(2‐oxoindolin‐3‐ylidene)malononitriles gives novel, potentially bioactive thiazole‐fused spirooxindoles with good product yields and excellent enantioselectivities.
ChemInform Abstract: Peptide‐Catalyzed Stereoselective Conjugate Addition Reactions of Aldehydes to Maleimide.
Authors: Gruenenfelder Claudio E. , Kisunzu Jessica K. , Wennemers Helma 
Published: November 2016

AbstractThe tripeptide H‐dPro‐Pro‐Asn‐NH2 is presented as catalyst for asymmetric conjugate addition reactions of aldehydes to maleimide.
ChemInform Abstract: From Aryl Iodides to 1,3‐Dipoles: Design and Mechanism of a Palladium Catalyzed Multicomponent Synthesis of Pyrroles.
Authors: Torres Gerardo M. , Quesnel Jeffrey S. , Bijou Diane , Arndtsen Bruce A. 
Published: November 2016

AbstractA three component reaction between imines, aryl iodides, and carbonmonoxide is developed which delivers 1,3‐dipoles prone for cycloaddition reactions with electron‐deficient terminal as well as internal alkynes or alkenes.
ChemInform Abstract: Promotion of 1,3‐Dipolar Cycloaddition Between Azides and β‐Enaminones by Deep Eutectic Solvents.
Authors: Pinto Martins Marcos Antonio , Caneppele Paveglio Guilherme , Valvassori Rodrigues Leticia , Piccinin Frizzo Clarissa , Zanatta Nilo , Bonacorso Helio Gauze 
Published: November 2016

AbstractThe 1,3‐dipolar cycloaddition between azides and β‐enaminones to afford triazole derivatives of type (III) is performed using the deep eutectic solvent choline chloride/ethylene glycol (1:2) as solvent.
ChemInform Abstract: Preparation of Novel 3‐Fluorophenyl Triazolothiadiazoles and of Triazolothiadiazines.
Authors: Aouad Mohamed R. , Al‐Saedi Amr M. Hassan , Ali Adeeb A. , Rezki Nadjet , Messali Mouslim 
Published: November 2016

AbstractThe title compounds are prepared by cyclization of amino(fluorophenyl)triazolethione (I) with versatile electrophiles under microwave irradiation conditions.
ChemInform Abstract: DABCO Catalyzed Unusual Formal [4 + 2] Cycloaddition of 3‐Acyl(or Alkoxycarbonyl)‐1,4‐enediones with 2,3‐Butadienoates: Effective Access to Highly Functionalized Pyrans.
Authors: Meng Xiang‐Suo , Jiang Shan , Xu Xiao‐Yun , Wu Qiang‐Xian , Gu Yu‐Cheng , Shi De‐Qing 
Published: November 2016

AbstractA novel regioselective one‐pot access to highly functionalized pyrans is described.
ChemInform Abstract: Direct and Facile Synthesis of 9‐Aminoacridine and Acridin‐9‐yl‐ureas.
Authors: Borovlev Ivan V. , Demidov Oleg P. , Amangasieva Gulminat A. , Avakyan Elena K. 
Published: November 2016

AbstractThe tautomerism and X ray structures of selected products is examined.
ChemInform Abstract: “Click‐fluors”: Triazole‐Linked Saccharide Sensors.
Authors: Zhai Wenlei , Chapin Brette M. , Yoshizawa Akina , Wang Hui‐Chen , Hodge Stephen A. , James Tony D. , Anslyn Eric V. , Fossey John S. 
Published: November 2016

AbstractUsing the CuAAC click strategy, several boronic acid‐containing saccharide receptors with triazole‐linked fluorophores are synthesized.
ChemInform Abstract: Delavatine A, a Structurally Unusual Cyclopenta[de]isoquinoline Alkaloid from Incarvillea delavayi
Authors: Zhang Zhongyin , Yang Fan , Fu Jian‐Jun , Shen Yun‐Heng , He Weiwei , Zhang Wei‐Dong 
Published: November 2016

Abstractisolation, structure and cytotoxicity against a panel of cancer cell lines
ChemInform Abstract: Synthesis, Characterization, and Application of Metal Nanoparticles Supported on Nitrogen‐Doped Carbon: Catalysis Beyond Electrochemistry
Authors: He Lin , Weniger Florian , Neumann Helfried , Beller Matthias 
Published: November 2016

AbstractReview: [use of metal nanoparticles modified by nitrogen‐doped carbon supports as promising catalysts for various transformations, including industrially relevant oxidations, reductions, Fischer—Tropsch syntheses, and H2 generation; 114 refs.
ChemInform Abstract: Effects of Hydrophobic Peptoid Substitutions on the Bacterial Cell Selectivity and Antimicrobial Activity of Piscidin 1
Authors: Jeong Min‐Cheol , Jeon Dasom , Shin Areum , Jin Sodam , Shin Song Yub , Park Yong Sun , Kim Yangmee 
Published: November 2016

AbstractReview: 28 refs.
ChemInform Abstract: Flavonoids and Naphthoflavonoids: Wider Roles in the Modulation of Cytochrome P450 Family 1 Enzymes
Authors: Dong Jinyun , Zhang Qijing , Cui Qing , Huang Guang , Pan Xiaoyan , Li Shaoshun 
Published: November 2016

AbstractReview: 106 refs.
Efficient Synthesis of Glycosylated Matijin‐Su Derivatives via Ultrasonic Irradiation
Authors: Liang Guangping , Hu Zhanxing , Yuan Jie , Liang Guangyi , Xu Bixue 
Published: November 2016

AbstractMatijin‐Su (1) is a phenylalanine dipeptide compound with anti‐hepatitis B virus (HBV) activity. Previous reports suggest that the synthesis of glycosylated Matijin‐Su derivatives needs at least 10 steps. To simplify the synthetic procedure, we have developed a shorter and more efficient method for the preparation via ultrasound irradiation. Two galactopyranosylated (2) and two glucopyranosylated (3) derivatives were synthesized in 6 or 7 steps. The overall yields for the total synthesis of galactopyranosylated derivatives were markedly increased to 39% (2a) or 22% (2b). And the yields for glucopyranosylated derivatives also reached 29% (3a) or 16% (3b).
Copper(I)‐Catalyzed Intramolecular N‐N Coupling of Cyclopropyl O‐Acyl Ketoximes: Synthesis of Spiro‐fused Pyrazolin‐5‐ones
Authors: Zhang Zhiguo , Li Junlong , Huang Guoqing , Sun Kai , Zhang Guisheng , Ma Nana , Liu Qingfeng , Liu Tongxin 
Published: November 2016

AbstractA convenient copper‐catalyzed approach has been developed for the synthesis of substituted spiro‐fused pyrazolin‐5‐ones from readily available cyclopropyl O‐acyl ketoximes via an intramolecular NN bond formation reaction. These catalytic reactions proceed in excellent yields with a broad scope.