bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Vinorelbine-Cisplatin with Gemcitabine-Cisplatin in Patients with Advanced Non-Small Cell Lung Cancer
Authors: Ozkaya Sevket , Findik Serhat , Uzun Oguz , Atici Atilla Guven , Erkan Levent 
Published: September 2017

Purpose The objective of this trial was to compare cisplatin-plus-vinorelbine regimen with cisplatin-plus-gemcitabine regimen in patients with stage IIIB-IV non-small cell lung cancer (NSCLC). Patients and Methods Chemonaive patients with stage IIIB-IV NSCLC received either vinoelbine 30 mg/m2 (days 1 and 8) plus cisplatin 80 mg/m2 (day 1) every 21 days (VC arm) or gemcitabine 1250 mg/m2 (days 1 and 8) plus cisplatin 80 mg/m2 (day 1) every 21 days (GC arm). Results One hundred thirtyfour patients (67 VC and 67 GC) were included to the study. Overall response rates for the VC arm (31.2%) were not significantly different from that of the GC arm (34.3%). There were no differences in overall survival and one-year survival rates. Median survival and one-year survival rates for the VC and GC groups were 10.6 and 11.5 months, 45% and 46.8%, respectively. Grade 3-4 thrombocytopenia was significantly higher on the GC arm (VC 1.4% v GC 8.9%, p < 0.05), as was febrile neutropenia on the VC arm (VC 8.9% v GC 1.4%, p < 0.05). Conclusion VC and GC demonstrated similar efficacy but there were differences in toxicity profiles.
Endoscopic Needle Knife Precut Papillotomy for Inaccessible Bile Duct following Failed Pancreatic Duct Access
Authors: Miyatani Hiroyuki , Yoshida Yukio 
Published: September 2017

Aims To evaluate the safety, effectiveness, success rate and complications of needle knife precut papillotomy for inaccessible bile duct after failed pancreatic ducts access. Methods Selective common bile duct cannulation was required for 582 patients from November 2004 to May 2008. Precut sphincterotomy was performed in 28 patients (16 male, 12 female; mean age 71). When standard bile duct cannulation was unsuccessful after more than 20 minutes, the bile duct was considered inaccessible. Group A consisted of patients where pancreatic duct access was possible and transpancreatic papillary septotomy was performed (20 patients). If pancreatic duct cannulation also failed, needle knife precut method was performed and these patients belonged to group B (8 patients). The success and complication rates of the two groups were compared using the Chi-square test. Results The success rates were 85% and 87.5% respectively. Of the 28 patients in group A, 6 had mild to moderate pancreatitis and one patient had mild bleeding. The complication rates were 35% and 0% respectively and the differences were not significant. Conclusion Needle knife precut papillotomy is useful and acceptable in patients after failed pancreatic duct access.
Emergency Medical Services Support for Acute Ischemic Stroke Patients Receiving Thrombolysis at a Primary Stroke Center
Authors: Spencer Byron R. , Khan Omar M. , Bobrow Bentley J. , Demaerschalk Bart M. 
Published: September 2017

Background Emergency Medical Services (EMS) is a vital link in the overall chain of stroke survival. A Primary Stroke Center (PSC) relies heavily on the 9-1-1 response system along with the ability of EMS personnel to accurately diagnose acute stroke. Other critical elements include identifying time of symptom onset, providing pre-hospital care, selecting a destination PSC, and communicating estimated time of arrival (ETA). Purpose Our purpose was to evaluate the EMS component of thrombolysed acute ischemic stroke patient care at our PSC. Methods In a retrospective manner we retrieved electronic copies of the EMS incident reports for every thrombolysed ischemic stroke patient treated at our PSC from September 2001 to August 2005. The following data elements were extracted: location of victim, EMS agency, times of dispatch, scene, departure, emergency department (ED) arrival, recordings of time of stroke onset, blood pressure (BP), heart rate (HR), cardiac rhythm, blood glucose (BG), Glasgow Coma Scale (GCS), Cincinnati Stroke Scale (CSS) elements, emergency medical personnel field assessment, and transport decision making. Results Eighty acute ischemic stroke patients received thrombolysis during the study interval. Eighty-one percent arrived by EMS. Two EMS agencies transported to our PSC. Mean dispatch-to-scene time was 6 min, on-scene time was 16 min, transport time was 10 min. Stroke onset time was recorded in 68%, BP, HR, and cardiac rhythm each in 100%, BG in 81%, GCS in 100%, CSS in 100%, and acute stroke diagnosis was made in 88%. Various diagnostic terms were employed: cerebrovascular accident in 40%, unilateral weakness or numbness in 20%, loss of consciousness in 16%, stroke in 8%, other stroke terms in 4%. In 87% of incident reports there was documentation of decision-making to transport to the nearest PSC in conjunction with pre-notification. Conclusion The EMS component of thrombolysed acute ischemic stroke patients care at our PSC appeared to be very good overall. Diagnostic accuracy was excellent, field assessment, decision-making, and transport times were very good. There was still room for improvement in documentation of stroke onset and in employment of a common term for acute stroke.
Views of Emergency Physicians on Thrombolysis for Acute Ischemic Stroke
Authors: Bobrow Bentley J. , Demaerschalk Bart M. , Wood Joseph P. , Villarin Albert , Clark Lani , Jennings Anthony 
Published: September 2017

Background The 3-hour window for treating stroke with intravenous tissue plasminogen activator (t-PA) requires well-organized, integrated efforts by emergency physicians and stroke neurologists. Objective To evaluate attitudes and knowledge of emergency physicians about intravenous t-PA for acute ischemic stroke, particularly in primary stroke centers (PSCs) with stroke neurology teams. Methods A 15-question pilot Internet survey administered by the Arizona College of Emergency Physicians. Results Between March and August 2005, 100 emergency physicians responded: 71 in Arizona and 29 in Missouri. Forty-eight percent practiced at PSCs; 48% thought t-PA was effective, 20% did not, and 32% were uncertain. PSC or non-PSC location of practice did not influence endorsement (odds ratio, 0.96; 95% confidence interval, 0.27–1.64). Of those opposing t-PA, 87% cited risk of hemorrhage. Conclusions Most emergency physicians did not endorse t-PA. Improved collaboration between emergency physicians and stroke neurologists is needed.
Triple-wavelength depolarization-ratio profiling of Saharan dust over Barbados during SALTRACE in 2013 and 2014
Authors: Haarig Moritz , Ansmann Albert , Althausen Dietrich , Klepel André , Groß Silke , Freudenthaler Volker , Toledano Carlos , Mamouri Rodanthi-Elisavet , Farrell David A. , Prescod Damien A. , Marinou Eleni , Burton Sharon P. , Gasteiger Josef , Engelmann Ronny , Baars Holger 
Published: September 2017

Abstract. Triple-wavelength polarization lidar measurements in Saharan dust layers were performed at Barbados (13.1° N, 59.6° W), 5000–8000 km west of the Saharan dust sources, in the framework of the Saharan Aerosol Long-range Transport and Aerosol-Cloud-Interaction Experiment (SALTRACE-1, June–July 2013, SALTRACE-3, June–July 2014). Three case studies are discussed. High quality was achieved by comparing the dust linear depolarization ratio profiles measured at 355, 532, and 1064 nm with respective dual-wavelength (355, 532 nm) depolarization ratio profiles measured with a reference lidar. A unique case of long-range transported dust over more than 12 000 km is presented. Saharan dust plumes crossing Barbados were measured with an airborne triple-wavelength polarization lidar over Missouri in the midwestern United States 7 days later. Similar dust optical properties and depolarization features were observed over both sites indicating almost unchanged dust properties within this 1 week of travel from the Caribbean to the United States. The main results of the triple-wavelength polarization lidar observations in the Caribbean in the summer seasons of 2013 and 2014 are summarized. On average, the particle linear depolarization ratios for aged Saharan dust were found to be 0.252 ± 0.030 at 355 nm, 0.280 ± 0.020 at 532 nm, and 0.225 ± 0.022 at 1064 nm after approximately 1 week of transport over the tropical Atlantic. Based on published simulation studies we present an attempt to explain the spectral features of the depolarization ratio of irregularly shaped mineral dust particles, and conclude that most of the irregularly shaped coarse-mode dust particles (particles with diameters > 1 µm) have sizes around 1.5–2 µm. The SALTRACE results are also set into the context of the SAMUM-1 (Morocco, 2006) and SAMUM-2 (Cabo Verde, 2008) depolarization ratio studies. Again, only minor changes in the dust depolarization characteristics were observed on the way from the Saharan dust sources towards the Caribbean.
Characterizing the spatial variations and correlations of large rainstorms for landslide study
Authors: Gao Liang , Zhang Limin , Lu Mengqian 
Published: September 2017

Abstract. Rainfall is the primary trigger of landslides in Hong Kong; hence, rainstorm spatial distribution is an important piece of information in landslide hazard analysis. The primary objective of this paper is to quantify spatial correlation characteristics of three landslide-triggering large storms in Hong Kong. The spatial maximum rolling rainfall is represented by a rotated ellipsoid trend surface and a random field of residuals. The maximum rolling 4, 12, 24, and 36 h rainfall amounts of these storms are assessed via surface trend fitting, and the spatial correlation of the detrended residuals is determined through studying the scales of fluctuation along eight directions. The principal directions of the surface trend are between 19 and 43°, and the major and minor axis lengths are 83–386 and 55–79 km, respectively. The scales of fluctuation of the residuals are found between 5 and 30 km. The spatial distribution parameters for the three large rainstorms are found to be similar to those for four ordinary rainfall events. The proposed rainfall spatial distribution model and parameters help define the impact area, rainfall intensity and local topographic effects for landslide hazard evaluation in the future.
Aggregation effects on tritium-based mean transit times and young water fractions in spatially heterogeneous catchments and groundwater systems
Authors: Stewart Michael K. , Morgenstern Uwe , Gusyev Maksym A. , Małoszewski Piotr 
Published: September 2017

Abstract. Kirchner (2016a) demonstrated that aggregation errors due to spatial heterogeneity, represented by two homogeneous subcatchments, could cause severe underestimation of the mean transit times (MTTs) of water travelling through catchments when simple lumped parameter models were applied to interpret seasonal tracer cycle data. Here we examine the effects of such errors on the MTTs and young water fractions estimated using tritium concentrations in two-part hydrological systems. We find that MTTs derived from tritium concentrations in streamflow are just as susceptible to aggregation bias as those from seasonal tracer cycles. Likewise, groundwater wells or springs fed by two or more water sources with different MTTs will also have aggregation bias. However, the transit times over which the biases are manifested are different because the two methods are applicable over different time ranges, up to 5 years for seasonal tracer cycles and up to 200 years for tritium concentrations. Our virtual experiments with two water components show that the aggregation errors are larger when the MTT differences between the components are larger and the amounts of the components are each close to 50 % of the mixture. We also find that young water fractions derived from tritium (based on a young water threshold of 18 years) are almost immune to aggregation errors as were those derived from seasonal tracer cycles with a threshold of about 2 months.
Rabindranath Tagore’s Syncretistic Philosophy and the Persian Sufi Tradition
Authors: Lewisohn Leonard 
Published: September 2017

Abstract
Rabindranath Tagore (1861–1941) has been praised by a number of Bengali Muslim authors for his sympathetic portrayal of Islamic concepts and ideals, and it is well known that some of his works of prose and verse were influenced by Persian poetry and Sufism. Tagore’s father knew Persian and could recite the poetry of Ḥāfiẓ (d. 1389) by heart. Tagore himself was also deeply influenced by the Persian classical poet. In the last decade of his life, Tagore described his admiration for the great Persian Sufi poets, visiting the tombs of Ḥāfiẓ and Sa‘dī in Shiraz. In this article, I will discuss the spiritual milieu of the Persianate culture of nineteenth- and early twentieth-century Bengal to shed light on the extent of the influence of Persian Sufi ideas on this milieu in general and Tagore in particular. Attention will also be given to other aspects of Tagore’s religious syncretism: Bāul mysticism and its lyric poetry, Sahaja Buddhism, Vedanta philosophy, the Upanishads, and a few other currents of Eastern thought. Lastly, I will explore Tagore’s relationship with Persian Sufi concepts and poetry and discuss the effect of his visit to Iran and his encounter with the poet Ḥāfiẓ.
HOPE Scholarship Status of Students in a Large General Education Course
Authors: Heaton Eleanore T. , Ciancio Dennis J. , Williams Robert L. 
Published: September 2017

Abstract
We examined the extent to which socioeconomic status (SES), precollege academic variables, non-course collegiate measures, and in-course collegiate measures predicted receipt and/or retention of a Helping Outstanding Pupils Educationally (HOPE) scholarship at a major southeastern state university. Students (N = 181) enrolled in seven sections of a 200-level general education course participated in the study. Logistic regression analyses revealed that SES and precollege academic models significantly predicted HOPE receipt. Within these models, high school grade point average proved to be the most consistent predictor of HOPE receipt. SES, in-course collegiate, and college grade models were the strongest predictors of HOPE retention.
Connecting Student Engagement to Student Satisfaction: A Case Study at East Carolina University
Authors: Pelletier Christopher , Rose Jaya , Russell Mona , Guberman Daniel , Das Kanchan , Bland Joseph , Bonner Heidi , Renée Chambers Crystal 
Published: September 2017

Abstract
The focus of the present study is whether student engagement as measured at the class level via the Classroom Level Survey of Student Engagement (CLASSE) is associated with higher levels of student satisfaction. To do so, we administered the CLASSE survey to 370 first-year, sophomore, junior, and senior students across nine classrooms. There were no statistically significant relationships between student engagement and overall satisfaction. When analyzed with student responses to questions about their satisfaction in the classroom, we found no variation in student satisfaction by race, gender, or class level. Implications for future research and practice are discussed.
Association between breastfeeding, obstetric factors and child development in Northeast Brazil
Authors: Severiano André Augusto De Oliveira , Dantas Diego De Sousa , Oliveira Vanessa Lopes Costa de , Lopes Johnnatas Mikael , Souza Damião Ernane de , Magalhães Adriana Gomes 
Published: September 2017

Introduction: Child development is a complex process influenced by several factors, among others is highlighted the practice of breastfeeding. Beyond the biological effects, breastfeeding has effects on the social dimension and the psychological apparatus of the actors directly involved. Objective: To analyse the influence of exclusive breastfeeding and associated factors on the neurodevelopment (ND) of children up to 36 months old. Methods: A cross-sectional, community-based study with individuated data of 99 children up to 36 months old, evaluated socio demographic, obstetric and neonatal variables and assessed ND through the Development Monitoring Instrument. The variables were analysed using descriptive statistics and regression testing. Data were considered significant when p <0.05. Results: Regarding ND, 70.71% of the children had achieved the motor milestones for their age, 98.99% of mothers breastfed, 37.38% of them had exclusive breastfed (EBF) for six months. Factors that positively influenced the ND were vaginal delivery when compared to children with other types of delivery, and EBF for 6 months when compared to children who had EBF less than six months. Conclusions: The practice of exclusive breastfeeding for less than six months is associated with a higher prevalence of lower psychomotor development of children from zero to 36 months old. Other factors associated with delay in development are instrumented vaginal delivery with forceps or caesarean delivery.
Heterologous expression of Plasmodium vivax apical membrane antigen 1 (PvAMA1) for binding peptide selection
Authors: Chew Ching Hoong , Lim Yvonne Ai Lian , Chua Kek Heng 
Published: September 2017

Background
Plasmodium is an obligate intracellular parasite. Apical membrane antigen 1 (AMA1) is the most prominent and well characterized malarial surface antigen that is essential for parasite-host cell invasion, i.e., for sporozoite to invade and replicate within hepatocytes in the liver stage and merozoite to penetrate and replicate within erythrocytes in the blood stage. AMA1 has long served as a potent antimalarial drug target and is a pivotal vaccine candidate. A good understanding of the structure and molecular function of this Plasmodium protein, particularly its involvement in host-cell adhesion and invasion, is of great interest and hence it offers an attractive target for the development of novel therapeutics. The present study aims to heterologous express recombinant Plasmodium AMA1 ectodomain of P. vivax (rPvAMA1) for the selection of binding peptides.

Methods
The rPvAMA1 protein was heterologous expressed using a tag-free Profinity eXactTM system and codon optimized BL21-Codon Plus (DE3)-RIL Escherichia coli strain and further refolded by dialysis for renaturation. Binding peptides toward refolded rPvAMA1 were panned using a Ph.D.-12 random phage display library.

Results
The rPvAMA1 was successfully expressed and refolded with three phage-displayed dodecapeptides designated as PdV1 (DLTFTVNPLSKA), PdV2 (WHWSWWNPNQLT), and PdV3 (TSVSYINNRHNL) with affinity towards rPvAMA1 identified. All of them exhibited positive binding signal to rPvAMA1 in both direct phage assays, i.e., phage ELISA binding assay and Western blot binding assay.

Discussion
Phage display technology enables the mapping of protein-protein interactions based on a simple principle that a library of phage particles displaying peptides is used and the phage clones that bind to the target protein are selected and identified. The binding sites of each selected peptides toward PvAMA1 (Protein Data Bank, PDB ID: 1W8K) were in silico predicted using CABS-dock web server. In this case, the binding peptides provide a valuable starting point for the development of peptidomimetic as antimalarial antagonists directed at PvAMA1.
Propuesta metodológica para conocer la percepción en responsabilidad social universitaria de una muestra de estudiantil en una universidad mexicana
Authors: Torres Sánchez Ulises 
Published: September 2017

Cuando se piensa en términos de responsabilidad social a menudo se involucra al ámbito económico o empresarial, no obstante, este concepto puede ser aplicado a cualquier tipo de organización, desde empresas, hasta sociedades civiles, organismos no gubernamentales o instituciones de educación superior. La universidad como está incluida dentro del marco de la responsabilidad social, con la característica que la docencia y formación ciudadana, así como la investigación y difusión del conocimiento, adscritas como ejes rectores en unión con la gestión organizacional y la gestión social ya existentes en cualquier organización.
En la presente investigación se incluyen los resultados de las dos primeras fases propuestas por Vallaeys, de la Crus y Sasia (2009) en el Manual de Primeros Pasos en Responsabilidad Social Universitaria. La Universidad Autónoma de Yucatán (UADY) ha adoptado dicho modelo para la consecución de su visión en el 2020, retomando del autor una metodología que divide en cuatro fases un plan de trabajo que significará una década de estrategias, propuestas y convenios que se realizarán en conjunto por directivos, administrativos, personal docente, personal manual y los estudiantes que conforman la universidad.
Se incluye de igual manera, la propuesta de trabajo que se realizará con los estudiantes de una facultad objetivo, correspondiente a la tercera fase denominada cumplimiento y que contiene como uno de sus primeras instrucciones, el contraste de los resultados obtenidos en el autodiagnóstico que la UADY realizó entre los años 2009 y 2010, con las propuestas de trabajo que el Consejero alumno y el Presidente estudiantil elaboraron para un periodo de trabajo de dos años. Serán los estudiantes los encargados de elaborar propuestas de trabajo que inviten a una participación activa en la adopción de un modelo de universidad responsable, que supervise e incluya los cuatro ámbitos que la Universidad de Yucatán ha identificado y establecido para lograr constituirse como la institución de educación superior, con los más altos estándares de responsabilidad social en México.
Ética recostructiva ante la globalización
Authors: Alvarez Osses Ingrid Adriana 
Published: September 2017

Este avance de investigación trata de exponer una ética crítica en relación a la globalización hegemónica. Así, se reflexiona con la ética del bien común de Franz Hinkelammert, los aportes del diálogo intercultural de Raúl Fornet-Betancourt, la ética de la liberación de Enrique Dussel, el pensar situado y contextual de Rodolfo Kusch. Al mismo tiempo es un escrito que reflexiona sobre los dilemas de la globalización, sobre todo, respecto a la polarización y el desencuentro entre unos y otros. Desde allí, se intenta avizorar perspectivas para una ética crítica y situada ante el orden cultural y económico que rige el mundo. La relevancia de otros supuestos que asientan cambiar la lógica de la negación y el no reconocimiento que han llevado a lo Mismo y la Totalidad. En esta perspectiva, se propone una ética reconstructiva para la rehabilitación del orden global que no escucha la voz de los que sufren el imperio del cálculo de utilidad y la ética funcional basada en el utilitarismo. Esto devela el vacío de solidaridad que clama responsabilidad con los sectores más postergados históricamente. Así, se propone una ética que potencie el diálogo hacia otras posibilidades humanas.
Redes Sociales de apoyo entre personas que viven en situación de calle en la ciudad de Temuco, Chile
Authors: Parada Hernández Héctor 
Published: September 2017

Las personas en situación de calle se han constituido en una forma de vida urbana que activa recursos propios y del entorno. El objetivo de este trabajo ha sido caracterizar socioculturalmente las redes sociales de apoyo de las personas en situación de calle. Corresponde a un estudio etnográfico realizado el año 2014 en dos espacios de concentración de personas en situación de calle en la ciudad de Temuco-Chile. La muestra de carácter intencional fueron 12 personas que accedieron a participar en el estudio. Se realizaron 12 entrevistas semiestructuradas y 90 observaciones participantes y no participantes. El análisis consistió en la codificación de las narrativas, levantamiento de categorías conceptuales, construcción de esquemas y redes de relación entre las categorías. Los resultados indican la presencia de cinco redes sociales de apoyo: institucionales, religiosas, genéricas, de pares y familiares; las cuales inciden sobre el estar-ser en la calle. Se concluye que las personas en situación de calle generan una lógica de asociatividad socio-cultural, configurando redes de apoyo particular, las cuales les confieren seguridad, estilo e identidad.