bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paternal history of depression or anxiety disorder and infant–father attachment
Authors: Lucassen Nicole , Tharner Anne , Prinzie Peter , Verhulst Frank C. , Jongerling Joran , Bakermans‐Kranenburg Marian J. , van IJzendoorn Marinus H. , Tiemeier Henning 
Published: November 2017

AbstractPaternal depression and anxiety are important risk factors for a problematic parent–child relationship and subsequent child development. We explored the association between paternal history of depression and anxiety disorder and infant–father attachment security, taking into account the possible mediating roles of sensitivity and perceived family stress. In a sample of 94 infant–father dyads, a structured diagnostic interview and a questionnaire on family stress were administered during pregnancy. Paternal sensitivity was observed using the Ainsworth coding scales, and infant–father attachment was observed in the strange situation procedure during a lab visit at 14 months. Linear regression models were used to examine the association of father's lifetime depression or anxiety with the continuous scales for infant–father attachment security and disorganization. Father's history of depression or anxiety disorder was not significantly related to infant–father attachment security in the total sample. Interestingly, daughters of fathers with a history of depression or anxiety had higher scores on attachment security than daughters of fathers without this diagnosis. Perceived family stress and paternal sensitivity were not significant mediators. We discuss these unexpected findings, suggesting alternative mechanisms for how paternal vulnerability to depression or anxiety may be associated with the infant–father attachment relationship.Highlights

We examine the association between paternal history of depression and anxiety disorder and infant‐father attachment security.
In 94 infant‐father dyads, a structured diagnostic interview was administered and infant‐father attachment was observed in the Strange Situation Procedure.
Daughters of fathers with a psychiatric history had higher scores on attachment security. Mechanisms of paternal vulnerability are discussed.
Association between urine retinol‐binding protein levels and nonalcoholic fatty liver disease: A cross‐sectional study in Chinese population
Authors: Zhang Juanwen , Liu Zeyu , Zhang Xuyao , Zhang Li , Jin Xi 
Published: November 2017

ObjectiveThe prevalence of nonalcoholic fatty liver disease (NAFLD) has been rapidly increased, becoming a public health problem worldwide. Our objective was to investigate the association between urine retinol‐binding protein (RBP) and NAFLD in a Chinese population and develop a multivariate logistic regression model for NAFLD prediction.MethodsA total of 317 NAFLD patients and 391 healthy controls were enrolled in this cross‐sectional study based on inclusion and exclusion criteria, from whom fasting urine and blood were collected for further study. Urine RBP level and other parameters were measured and compared between NAFLD subjects and controls.ResultsUrine RBP levels (expressed by RBP/creatinine ratio) in NAFLD patients were significantly higher than controls (median 133.1 mg/g vs 110.7 mg/g; P < .001). Urine RBP/creatinine ratio was verified as an independent factor for NAFLD prediction after adjustment in multivariate logistic regression. The area under curve (AUC) of receiver operating characteristic (ROC) was 0.889 with the 95% confidence interval from 0.867 to 0.912.With a cutoff point of 0.215, the sensitivity and specificity of urine RBP/creatinine ratio in NAFLD prediction were 81.1% and 84.5%, respectively.ConclusionOur results demonstrated that urine RBP/creatinine ratio was an independent risk factor for NAFLD while the predictive model for NAFLD diagnosis is noninvasive with high sensitivity and specificity.
Measurement of HE4 and CA125 and establishment of reference intervals for the ROMA index in the sera of pregnant women
Authors: Lu Jie , Zheng Zhipeng , Zhang Qi , Li Guoli , Li Fengying , Le Zhian , Huang Jun , Xie Xinyou , Zhang Jun 
Published: November 2017

IntroductionCancer antigen 125 (CA125) and human epididymis protein 4 (HE4) are biomarkers for ovarian cancer. Their specificity and sensitivity are often limited during pregnancy as a result of great fluctuations. The risk of ovarian malignancy algorithm (ROMA) score, which combines CA125, HE4, and menopausal status, may improve diagnostic performance. There are no reports regarding the ROMA index in pregnant women. Therefore, the aim of our study was to establish appropriate reference intervals (RIs) for the ROMA index in pregnant Chinese women and compare them with those of CA125 and HE4 during pregnancy.MethodsSerum concentrations of CA125 and HE4 were simultaneously measured in healthy pregnant women via electrochemiluminescence immunoassay (ECLIA). The ROMA index was calculated using premenopausal algorithms.ResultsThe RIs for the ROMA index calculated by premenopausal algorithms were substantially closer to the normal range in the first 2 trimesters. For pregnant women, the great misclassifications identified in CA125 may be reversed by the use of ROMA index.ConclusionsWe established the RIs for HE4 and CA125, as well as the ROMA index, in pregnant women at different gestational periods. The ROMA index is suggested to be a more promising tumor marker for pregnant women diagnosed with malignance.
Chemometric analysis of minerals in gluten‐free products
Authors: Gliszczyńska‐Świgło Anna , Klimczak Inga , Rybicka Iga 
Published: November 2017

AbstractBACKGROUNDNumerous studies indicate mineral deficiencies in people on a gluten‐free (GF) diet. These deficiencies may indicate that GF products are a less valuable source of minerals than gluten‐containing products. In the study, the nutritional quality of 50 GF products is discussed taking into account the nutritional requirements for minerals expressed as percentage of recommended daily allowance (%RDA) or percentage of adequate intake (%AI) for a model celiac patient. Elements analyzed were calcium, potassium, magnesium, sodium, copper, iron, manganese, and zinc. Analysis of %RDA or %AI was performed using principal component analysis (PCA) and hierarchical cluster analysis (HCA).RESULTSUsing PCA, the differentiation between products based on rice, corn, potato, GF wheat starch and based on buckwheat, chickpea, millet, oats, amaranth, teff, quinoa, chestnut, and acorn was possible. In the HCA, four clusters were created. The main criterion determining the adherence of the sample to the cluster was the content of all minerals included to HCA (K, Mg, Cu, Fe, Mn); however, only the Mn content differentiated four formed groups.CONCLUSIONGF products made of buckwheat, chickpea, millet, oats, amaranth, teff, quinoa, chestnut, and acorn are better source of minerals than based on other GF raw materials, what was confirmed by PCA and HCA. © 2017 Society of Chemical Industry
Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society
Authors: Bhatia Kailash P. , Bain Peter , Bajaj Nin , Elble Rodger J. , Hallett Mark , Louis Elan D. , Raethjen Jan , Stamelou Maria , Testa Claudia M. , Deuschl Guenther ,   the Tremor Task Force of the International Parkinson and Movement Disorder Society
Published: November 2017

ABSTRACTBackgroundConsensus criteria for classifying tremor disorders were published by the International Parkinson and Movement Disorder Society in 1998. Subsequent advances with regard to essential tremor, tremor associated with dystonia, and other monosymptomatic and indeterminate tremors make a significant revision necessary.ObjectivesConvene an international panel of experienced investigators to review the definition and classification of tremor.MethodsComputerized MEDLINE searches in January 2013 and 2015 were conducted using a combination of text words and MeSH terms: “tremor”, “tremor disorders”, “essential tremor”, “dystonic tremor”, and “classification” limited to human studies. Agreement was obtained using consensus development methodology during four in‐person meetings, two teleconferences, and numerous manuscript reviews.ResultsTremor is defined as an involuntary, rhythmic, oscillatory movement of a body part and is classified along two axes: Axis 1—clinical characteristics, including historical features (age at onset, family history, and temporal evolution), tremor characteristics (body distribution, activation condition), associated signs (systemic, neurological), and laboratory tests (electrophysiology, imaging); and Axis 2—etiology (acquired, genetic, or idiopathic). Tremor syndromes, consisting of either isolated tremor or tremor combined with other clinical features, are defined within Axis 1. This classification scheme retains the currently accepted tremor syndromes, including essential tremor, and provides a framework for defining new syndromes.ConclusionsThis approach should be particularly useful in elucidating isolated tremor syndromes and syndromes consisting of tremor and other signs of uncertain significance. Consistently defined Axis 1 syndromes are needed to facilitate the elucidation of specific etiologies in Axis 2. © 2017 International Parkinson and Movement Disorder Society
Effectiveness of fenugreek as a galactagogue: A network meta‐analysis
Authors: Khan Tahir Mehmood , Wu David Bin‐Chia , Dolzhenko Anton V. 
Published: November 2017

A systematic review and network‐meta analysis (NMA) were performed to test significance of the galactagogue effect of fenugreek administrated to lactating women versus other comparators (i.e., placebo/control/other galactagogues). A pairwise comparison for the treatment effect was carried out to generate the forest plot for the NMA. League tables were generated using treatment effect, weighted mean difference (WMD; 95% confidence interval, CI) for all pairwise comparisons, where WMD > 0 favors the column‐defining treatment. Five studies were identified with 122 participants receiving treatment with fenugreek. The NMA results of 4 studies indicated that consumption of fenugreek significantly increased amount of the produced breast milk [11.11, CI 95% 6.77, 15.46] versus placebo. The pairwise comparison revealed that fenugreek was effective as a galactagogue compared to placebo, control, and reference groups WMD 17.79 [CI 11.71, 23.88]. However, the effect of fenugreek was substantially inferior to Coleus amboinicus Lour and palm date. The NMA using pairwise comparison demonstrated the effect of C. amboinicus and palm date in the stimulation of the breast milk production was comparable and superior to all comparators.
Note on discounted continuous-time Markov decision processes with a lower bounding function
Authors: Guo Xin , Piunovskiy Alexey , Zhang Yi 
Published: November 2017

AbstractWe consider the discounted continuous-time Markov decision process (CTMDP), where the negative part of each cost rate is bounded by a drift function, sayw, whereas the positive part is allowed to be arbitrarily unbounded. Our focus is on the existence of a stationary optimal policy for the discounted CTMDP problems out of the more general class. Both constrained and unconstrained problems are considered. Our investigations are based on the continuous-time version of the Veinott transformation. This technique has not been widely employed in the previous literature on CTMDPs, but it clarifies the roles of the imposed conditions in a rather transparent way.
A dichotomy for sampling barrier-crossing events of random walks with regularly varying tails
Authors: Dieker A. B. , Lagos Guido R. 
Published: November 2017

AbstractWe study how to sample paths of a random walk up to the first time it crosses a fixed barrier, in the setting where the step sizes are independent and identically distributed with negative mean and have a regularly varying right tail. We introduce a desirable property for a change of measure to be suitable for exact simulation. We study whether the change of measure of Blanchet and Glynn (2008) satisfies this property and show that it does so if and only if the tail index α of the right tail lies in the interval (1, 3/2).
Functional status of microvascular vasomotion is impaired in spontaneously hypertensive rat
Authors: Liu Mingming , Zhang Xiaoyan , Wang Bing , Wu Qingbin , Li Bingwei , Li Ailing , Zhang Honggang , Xiu Ruijuan 
Published: November 2017

AbstractAccumulating evidence demonstrates that microcirculation plays a role in the pathogenesis of hypertension. In the current study, we demonstrated that pancreatic islet microvascular vasomotion of spontaneously hypertensive rats (SHRs) lost the ability to regulate blood flow perfusion and exhibited a lower microvascular blood perfusion pattern which was negative correlated with blood glucose level. SHRs administrated with insulin revealed an improvement of pancreatic islet microvascular vasomotion and blood perfusion pattern. In vitro, the expressions of endothelial nitric oxide synthase (eNOS) and phospho-eNOSser1177 (p-eNOSser1177) were significantly decreased in high glucose exposed islet endothelial cells (iECs), accompanied with a higher ratio of eNOS monomer to eNOS dimer and a significantly increased malondialdehyde and nitrite levels. Meanwhile, barrier function, tube formation and migration capacities of high glucose exposed iECs were significantly inhibited. In contrast, iECs dysfunction induced by glucose toxicity and oxidative stress was attenuated or improved by supplement with insulin, L-arginine and β-mercaptoethanol. In summary, our findings suggest that functional status of pancreatic islet microvascular vasomotion is impaired in SHRs and provide evidence that treatment with insulin, L-arginine and β-mercaptoethanol improves endothelium-dependent microvascular vasomotion and meliorates iECs function due to anti-hyperglycemic and anti-oxidative effects, partly through mechanism involving regulation of eNOS and p-eNOSser1177.
Altered spontaneous calcium signaling of in situ chondrocytes in human osteoarthritic cartilage
Authors: Gong Xiaoyuan , Xie Wenbin , Wang Bin , Gu Lingchuan , Wang Fuyou , Ren Xiang , Chen Cheng , Yang Liu 
Published: November 2017

AbstractIntracellular calcium ([Ca2+]i) signaling is an essential universal secondary messenger in articular chondrocytes. However, little is known about its spatiotemporal features in the context of osteoarthritis (OA). Herein, by examining the cartilage samples collected from patients undergoing knee arthroscopic surgery, we investigated the spatiotemporal features of spontaneous [Ca2+]i signaling in in situ chondrocytes at different OA stages. Our data showed zonal dependent spontaneous [Ca2+]i signaling in healthy cartilage samples under 4 mM calcium environment. This signal was significantly attenuated in healthy cartilage samples but increased in early-degenerated cartilage when cultured in 0 mM calcium environment. No significant difference was found in [Ca2+]i intensity oscillation in chondrocytes located in middle zones among ICRS 1–3 samples under both 4 and 0 mM calcium environments. However, the correlation was found in deep zone chondrocytes incubated in 4 mM calcium environment. In addition, increased protein abundance of Cav3.3 T-type voltage dependent calcium channel and Nfatc2 activity were observed in early-degenerated cartilage samples. The present study exhibited OA severity dependent spatiotemporal features of spontaneous [Ca2+]i oscillations of in situ chondrocytes, which might reflect the zonal specific role of chondrocytes during OA progression and provide new insight in articular cartilage degradation during OA progression.
Evolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment
Authors: Sánchez-Illana Ángel , Núñez-Ramiro Antonio , Cernada María , Parra-Llorca Anna , Valverde Eva , Blanco Dorotea , Moral-Pumarega Maria Teresa , Cabañas Fernando , Boix Hector , Pavon Antonio , Chaffanel Mercedes , Benavente-Fernández Isabel , Tofe Inés , Loureiro Begoña , Fernández-Lorenzo José R. , Fernández-Colomer Belén , García-Robles Ana , Kuligowski Julia , Vento Máximo ,   HYPOTOP Study Group, Cordeiro Malaika , Arriaga María , Ureta-Velasco Noelia , Caballero M. Angeles , Fernández Cristina , Castilla Yolanda , Ferreira J. F. , Lubián-López Simón P. , Jaraba Pilar , López de Heredia Jon 
Published: November 2017

AbstractTherapeutic hypothermia (TH) initiated within 6 h from birth is the most effective therapeutic approach for moderate to severe hypoxic-ischemic encephalopathy (HIE). However, underlying mechanisms and effects on the human metabolism are not yet fully understood. This work aims at studying the evolution of several energy related key metabolites in newborns with HIE undergoing TH employing gas chromatography – mass spectrometry. The method was validated following stringent FDA requirements and applied to 194 samples from a subgroup of newborns with HIE (N = 61) enrolled in a multicenter clinical trial (HYPOTOP) for the determination of lactate, pyruvate, ketone bodies and several Krebs cycle metabolites at different sampling time points. The analysis of plasma samples from newborns with HIE revealed a decrease of lactate, pyruvate and β-hydroxybutyrate concentrations, whereas rising malate concentrations were observed. In healthy control newborns (N = 19) significantly lower levels of pyruvate and lactate were found in comparison to age-matched newborns with HIE undergoing TH, whereas acetoacetate and β-hydroxybutyrate levels were clearly increased. Access to a validated analytical method and a controlled cohort of newborns with HIE undergoing hypothermia treatment for the first time allowed the in-depth study of the evolution of key metabolites of metabolic junctions in this special population.
Healthy food choices are happy food choices: Evidence from a real life sample using smartphone based assessments
Authors: Wahl Deborah R. , Villinger Karoline , König Laura M. , Ziesemer Katrin , Schupp Harald T. , Renner Britta 
Published: November 2017

AbstractResearch suggests that “healthy” food choices such as eating fruits and vegetables have not only physical but also mental health benefits and might be a long-term investment in future well-being. This view contrasts with the belief that high-caloric foods taste better, make us happy, and alleviate a negative mood. To provide a more comprehensive assessment of food choice and well-being, we investigated in-the-moment eating happiness by assessing complete, real life dietary behaviour across eight days using smartphone-based ecological momentary assessment. Three main findings emerged: First, of 14 different main food categories, vegetables consumption contributed the largest share to eating happiness measured across eight days. Second, sweets on average provided comparable induced eating happiness to “healthy” food choices such as fruits or vegetables. Third, dinner elicited comparable eating happiness to snacking. These findings are discussed within the “food as health” and “food as well-being” perspectives on eating behaviour.
Effective in vivo gene delivery with reduced toxicity, achieved by charge and fatty acid -modified cell penetrating peptide
Authors: Kurrikoff Kaido , Veiman Kadi-Liis , Künnapuu Kadri , Peets Elin Madli , Lehto Tõnis , Pärnaste Ly , Arukuusk Piret , Langel Ülo 
Published: November 2017

AbstractNon-viral gene delivery systems have gained considerable attention as a promising alternative to viral delivery to treat diseases associated with aberrant gene expression. However, regardless of extensive research, only a little is known about the parameters that underline in vivo use of the nanoparticle-based delivery vectors. The modest efficacy and low safety of non-viral delivery are the two central issues that need to be addressed. We have previously characterized an efficient cell penetrating peptide, PF14, for in vivo applications. In the current work, we first develop an optimized formulation of PF14/pDNA nanocomplexes, which allows removal of the side-effects without compromising the bioefficacy in vivo. Secondly, based on the physicochemical complex formation studies and biological efficacy assessments, we develop a series of PF14 modifications with altered charge and fatty acid content. We show that with an optimal combination of overall charge and hydrophobicity in the peptide backbone, in vivo gene delivery can be augmented. Further combined with the safe formulation, systemic gene delivery lacking any side effects can be achieved.
Localised surface plasmons of a corrugated metal–insulator–metal ring resonator for enhanced multiband antenna
Authors: Zavvari M. , Ebadzadeh R. , Mohammadifar M. 
Published: November 2017

A compact multiband antenna is presented by using a metal–insulator–metal (MIM) ring resonator in its ground plane. Two arrays of corrugated MIM are served as ring resonator and surround the radiating patch. The localised surface plasmons of the resonator are excited by the patch to show multi‐band operation of antenna. Design procedure of ring resonators and its impact on the impedance matching in multi‐band operation is studied and the results are validated by experimental analysis of fabricated structure. The presented CPW‐fed antenna operates at five bands, WLAN in 2.4‐GHz (2.4–2.484 GHz), 5.2‐GHz (5.15–5.35 GHz), C‐Band in 6.5‐GHz (6–7 GHz) and X‐Band in 9‐GHz (8.5–10 GHz), 9.8 GHz (9.7–9.9 GHz).
Cardiac Air Embolism in Neonates: A Hemodynamic Perspective
Authors: Amer Reem , Elsayed Yasser , Louis Deepak 
Published: November 2017

AbstractCardiac air embolism should be suspected in any neonate with acute unexplained cardiovascular collapse or worsening oxygenation. We present here five cases that presented with the above symptoms. A comprehensive evaluation including targeted neonatal echocardiography and near-infrared spectroscopy helped confirm the diagnosis and assess the hemodynamic state. Management was supportive including left lateral positioning, chest compressions, and cardiovascular medications to treat pulmonary hypertension and systemic hypotension.
Effekte der telefonischen Nachsorge in der onkologischen Rehabilitation nach Brustkrebs – Ergebnisse einer randomisierten Studie
Authors: Hass H. , Muthny F. , Stepien J. , Lerch J. , von der Marwitz C. , Schröck R. , Berger D. , Tripp J. 
Published: November 2017

Zusammenfassung
Hintergrund Die Effekte und Evidenz der onkologischen Rehabilitation und von Nachsorgeprogrammen nach onkologischer Erkrankung werden unverändert kontrovers beurteilt. Ziel dieser Studie war daher die Evaluation der Durchführbarkeit und der Nutzen einer telefonischen Nachsorge zur Verbesserung von therapeutischen Effekten nach onkologischer Rehabilitation.
Methodik 172 Brustkrebspatientinnen (27 – 54 Jahre) wurden zu Beginn der stationären Rehabilitation (T1), zu Reha-Ende (T2) und 6 Monate nach Reha-Ende (T3) (Kontroll-Gruppe ohne, Interventionsgruppe mit telefonischer Nachsorge in 4-wöchigen Abständen) mit einem Fragebogenpaket untersucht (u. a. IRES-24. HADS, LZI, Emotional Thermometer, Fragebogen „Return-to-work).
Ergebnisse Für den IRES-24 ergab sich in der 2-faktoriellen Varianzanalyse ein signifikanter Haupteffekt für den Messzeitpunkt (F(2,116) = 40,49, p < 0,01), ebenso für den HADS-Angst- sowie Depressionswert (F(2,117) = 31,50, p < 0,01; (F(2,11 6) = 31,19, p < 0,01), jedoch keine signifikanten Unterschiede in Abhängigkeit von der Intervention (KG vs. NG; (F(2,116) = 3,03, p = 0,059).
Schlussfolgerung Eine Verbesserung der Wirkung durch die telefonische Nachsorge ließ sich nicht belegen. Ursächlich hierfür könnte neben einer zu geringen Dosis der Intervention auch die in den letzten Jahren schon umgesetzten multimodalen Therapiekonzepte in der onkologischen Rehabilitation sein.