bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide association studies on periodontitis: A systematic review
Authors: Gao Chenyi , Iles Mark , Larvin Harriet , Bishop David Timothy , Bunce David , Ide Mark , Sun Fanyiwen , Pavitt Susan , Wu Jianhua , Kang Jing 
Published: September 2024

Objectives
This study aims to systematically review the existing literature and critically appraise the evidence of genome-wide association studies (GWAS) on periodontitis. This study also aims to synthesise the findings of genetic risk variants of periodontitis from included GWAS.

Methods
A systematic search was conducted on PubMed, GWAS Catalog, MEDLINE, GLOBAL HEALTH and EMBASE via Ovid for GWAS on periodontitis. Only studies exploring single-nucleotide polymorphisms(SNPs) associated with periodontitis were eligible for inclusion. The quality of the GWAS was assessed using the Q-genie tool. Information such as study population, ethnicity, genomic data source, phenotypic characteristics(definition of periodontitis), and GWAS methods(quality control, analysis stages) were extracted. SNPs that reached conventional or suggestive GWAS significance level(5e-8 or 5e-06) were extracted and synthesized.

Results
A total of 15 good-quality GWAS on periodontitis were included (Q-genie scores ranged from 38–50). There were huge heterogeneities among studies. There were 11 identified risk SNPs (rs242016, rs242014, rs10491972, rs242002, rs2978951, rs2738058, rs4284742, rs729876, rs149133391, rs1537415, rs12461706) at conventional GWAS significant level (p<5x10-8), and 41 at suggestive level (p<5x10-6), but no common SNPs were found between studies. Three SNPs (rs4284742 [G], rs11084095 [A], rs12461706 [T]) from three large studies were from the same gene region–SIGLEC5.

Conclusion
GWAS of periodontitis showed high heterogeneity of methodology used and provided limited SNPs statistics, making identifying reliable risk SNPs challenging. A clear guidance in dental research with requirement of expectation to make GWAS statistics available to other investigators are needed.
Noninvasive vs invasive respiratory support for patients with acute hypoxemic respiratory failure
Authors: Mosier Jarrod M. , Subbian Vignesh , Pungitore Sarah , Prabhudesai Devashri , Essay Patrick , Bedrick Edward J. , Stocking Jacqueline C. , Fisher Julia M. 
Published: September 2024

Background
Noninvasive respiratory support modalities are common alternatives to mechanical ventilation in acute hypoxemic respiratory failure. However, studies historically compare noninvasive respiratory support to conventional oxygen rather than mechanical ventilation. In this study, we compared outcomes in patients with acute hypoxemic respiratory failure treated initially with noninvasive respiratory support to patients treated initially with invasive mechanical ventilation.

Methods
This is a retrospective observational cohort study between January 1, 2018 and December 31, 2019 at a large healthcare network in the United States. We used a validated phenotyping algorithm to classify adult patients (≥18 years) with eligible International Classification of Diseases codes into two cohorts: those treated initially with noninvasive respiratory support or those treated invasive mechanical ventilation only. The primary outcome was time-to-in-hospital death analyzed using an inverse probability of treatment weighted Cox model adjusted for potential confounders. Secondary outcomes included time-to-hospital discharge alive. A secondary analysis was conducted to examine potential differences between noninvasive positive pressure ventilation and nasal high flow.

Results
During the study period, 3177 patients met inclusion criteria (40% invasive mechanical ventilation, 60% noninvasive respiratory support). Initial noninvasive respiratory support was not associated with a decreased hazard of in-hospital death (HR: 0.65, 95% CI: 0.35–1.2), but was associated with an increased hazard of discharge alive (HR: 2.26, 95% CI: 1.92–2.67). In-hospital death varied between the nasal high flow (HR 3.27, 95% CI: 1.43–7.45) and noninvasive positive pressure ventilation (HR 0.52, 95% CI 0.25–1.07), but both were associated with increased likelihood of discharge alive (nasal high flow HR 2.12, 95 CI: 1.25–3.57; noninvasive positive pressure ventilation HR 2.29, 95% CI: 1.92–2.74).

Conclusions
These data show that noninvasive respiratory support is not associated with reduced hazards of in-hospital death but is associated with hospital discharge alive.
“Pictures helped me understand it in a way words couldn’t”: Youth reflections participating in a youth-led photovoice study
Authors: Mckee Shelby , Halsall Tanya , Sheikhan Natasha Y. , Knight Rodney , Henderson Jo , Hawke Lisa D. 
Published: September 2024

Introduction
People with lived experience of a health issue can be engaged in research to address issues related to social justice, informing change through partnerships and an understanding of community perspectives and needs. Although photovoice has been applied to various disciplines and topics across the health sciences, the concrete design of the photovoice process and participants’ experience of engaging in photovoice is not always well documented or understood.

Objective
This paper describes youth participants’ experiences and perspectives with a youth-led photovoice design process on a study regarding COVID-19 vaccine confidence.

Method
The sample consisted of 27 youth aged 14–24 who reported experiencing mental health and/or substance use challenges [MHSU] during the COVID-19 pandemic and some degree of COVID-19 vaccine confidence. Youth participated in a series of photography workshops, then each attended one of the six focus groups about both the topic and experience of the photovoice project.

Results
Four themes were constructed from the data: 1) Participating in a photovoice project was an enjoyable experience that had a positive effect on participants; 2) Shared group experiences contributed to building a safe space for participants; 3) Photography and the photovoice process served as a catalyst for reflection; 4) Photovoice shifted participants’ perspectives on both the COVID-19 vaccine and photography.

Conclusions
This project, a youth-engaged and youth-led photovoice study, describes how the photovoice methodology can be applied in a public health context to meaningfully involve young people and impact their lives. By involving youth in the co-construction of the study design and implementation, photovoice research can represent positive and empowering experiences for participants. Bringing together a diverse and multifaceted lived experience engagement research team structure strengthened the design, delivery, analysis, and interpretation of the project.
Endoscopic treatment of obesity: A protocol of updated systematic review with network meta-analysis of randomized controlled trials
Authors: Gong Eun Jeong , Bang Chang Seok , Baik Gwang Ho 
Published: September 2024

Background
Obesity, characterized by excessive fat accumulation, poses a significant public health challenge globally. Recent advancements in medical technology have heralded the emergence of endoscopic bariatric treatments (EBTs) as innovative alternatives to conventional obesity interventions. Despite previous systematic reviews and network meta-analyses, they also highlighted discrepancies in outcomes and efficacy among different EBTs. Here, we will update a systematic review and network meta-analysis of randomized controlled trials (RCTs) focusing on EBTs and presents a protocol for the reproducibility and transparency.

Methods
The core protocol of this study was registered at PROSPERO database (CRD42024514249) on Jan 2024. Core databases including MEDLINE through PubMed, Embase, and Cochrane library will be searched relevant studies, and a systematic review with network meta-analysis will be performed. Two evaluators (EJ Gong and CS Bang) will independently screen the titles and abstracts following the eligibility criteria; (1) RCTs investigated the compared the efficacy of EBTs and controls; (2) studies published in English; and (3) studies in full-text format. We will exclude studies meeting the following criteria; (1) studies that did not report the treatment outcomes, such as percent excess weight loss or percent total body weight loss; (2) case reports and review articles; (3) ineligible research objects, for example, animals or children; and (4) insufficient data regarding treatment outcome. The primary outcomes will be the common efficacy metric found after systematic review of relevant studies, such as percent excess weight loss or percent total body weight loss with a follow-up of at least 6 months. Narrative (descriptive) synthesis is planned and quantitative synthesis will be used if the included studies are sufficiently homogenous. The quality of the identified studies will be assessed using the Cochrane Risk of Bias assessment tool version 2.0 (ROB 2.0). All the systematic review and network meta-analysis process will be undertaken keeping the principles of the Preferred Reporting Items for a Systematic Review and Meta-analysis for systematic review protocols (PRISMA-P) and PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions (PRISMA-NMA).

Discussion
This updated systematic review and network meta-analysis will provide information about comparative efficacy of various EBTs and this will help physicians in the decision-making process for the selection of treatment modalities in the clinical practice.
Increased risk of cardiac arrhythmia in Hailey-Hailey disease patients
Authors: Jebril William , Curman Philip , Andersson Daniel C. , Larsson Henrik , Bachar-Wikstrom Etty , Cederlöf Martin , Wikstrom Jakob D. 
Published: September 2024

Background
Hailey-Hailey disease (HHD) is a rare autosomal dominant skin disease caused by mutations in the ATP2C1 gene, which encodes the secretory Ca2+/Mn2+-ATPase (SPCA1) pump in the Golgi apparatus. Although ATP2C1 is ubiquitously expressed in the body, possible extracutaneous manifestations of HHD are unknown. However, dysfunction of the Golgi apparatus not specifically coupled to ATP2C1 has been associated with heart disease.

Objective
To investigate the association between HHD and common heart disease in a Swedish, population-based cohort.

Methods
We conducted a population-based cohort study based on a linkage of Swedish nationwide registers to investigate the relationship between HHD and heart disease. We have been granted ethical approval from the Swedish Ethical Review Authority to conduct this study. The patients in this manuscript have given written informed consent to the publication of their case details. A total of 342 individuals with an ICD-10 diagnosis of HHD (Q82.8E) were identified and matched with randomly selected comparison individuals without HHD on a 1:100 ratio. Furthermore, in a separate clinical cohort we matched 23 HHD patients for age, sex, and BMI with control subjects to examine electrocardiogram parameters, electrolytes, and cardiovascular biomarkers.

Results
Compared with individuals without HHD, individuals with HHD had an excess risk of arrhythmia (RR 1.4, CI 1.0–2.0), whereas no increased risks of myocardial infarction (RR 1.1, CI 0.6–1.7) or heart failure (RR 1.0, CI 0.6–1.6; Table 1) were found. We found no difference in ECG parameters, cardiovascular biomarkers, and electrolytes in the clinical subset.

Conclusion
This study reveals that HHD is associated with an increased risk of arrhythmia and represents the first data of any extracutaneous comorbidity in HHD. Thus, HHD may be a systemic disease. Our findings also shed light on the importance of the Golgi apparatus’ Ca2+/Mn2+ homeostasis in common heart disease.
In their own words: Perspectives of IPV survivors on obtaining support within the healthcare system
Authors: Hargrave Anita S. , Dawson-Rose Carol , Schillinger Dean , Ng Fiona , Valdez Jessica , Rodriguez Amanda , Cuca Yvette P. , Bakken E. Hayes , Kimberg Leigh 
Published: September 2024

Background
Almost half of all women in the US experience intimate partner violence (IPV) in their lifetime. The US Preventive Services Task Force recommends IPV screening paired with intervention for women of reproductive age. We aim to understand clinical practices and policies that are beneficial, detrimental, or insufficient to support survivors of IPV in a safety-net healthcare system.

Methods
We sampled 45 women who were 18–64 years old, had experienced IPV within the prior year and were patients in the San Francisco Health Network. We conducted in-depth, semi-structured interviews to elicit their perspectives on disclosing IPV and obtaining support within the healthcare system. We analyzed our data using thematic analysis and grounded theory practices informed by ecological systems theory.

Findings
We identified four themes regarding factors that impeded or facilitated discussing and addressing IPV across interpersonal and systemic levels relating to relationship-building, respect, autonomy and resources. (1) Interpersonal barriers included insufficient attention to relationship-building, lack of respect or concern for survivor circumstances, and feeling pressured to disclose IPV or to comply with clinicians’ recommended interventions. (2) Interpersonal facilitators consisted of patient-centered IPV inquiry, attentive listening, strength-based counseling and transparency regarding confidentiality. (3) Systemic barriers such as visit time limitations, clinician turn-over and feared loss of autonomy from involvement of governmental systems leading to separation from children or harm to partners, negatively affected interpersonal dynamics. (4) Systemic facilitators involved provision of resources through IPV universal education, on-site access to IPV services, and community partnerships.

Conclusions
Women experiencing IPV in our study reported that relationship-building, respect, autonomy, and IPV-related resources were essential components to providing support, promoting safety, and enabling healing in the healthcare setting. Successful trauma-informed transformation of healthcare systems must optimize interpersonal and systemic factors that improve survivor wellbeing while eliminating barriers.
Big history
Authors: Horský Jan , Havelka Miloš 
Published: September 2024

Koncepce big history zde podrobujeme kritice z konstruktivistické perspektivy a z pohledu historickovědního nominalismu. Ukazujeme, že pokud by big history směřovala k tomu, aby byla jen jakousi scientifikací Hegelovy filosofie dějin, nebyla by epistemologicky produktivní. Bude-li big history ale rozvíjena na půdě konstruktivistické metodologie dějepisectví, může být vhodným korektivem přílišné drobnohlednosti některých směrů současného dějepisectví. Svoji argumentaci opíráme o rozbor původu problému celistvosti komplexity dějin v debatách mezi filosofií dějin a rodící se historickou vědou v 19. století, dále například o vymezení vztahu mezi big history, histoire totale a velkými procesuálními dějinami. Velké dějinné koncepce se nám jeví jako vždy kulturně zbarvené a zároveň otevřenou otázkou zůstává míra jejich možné hodnotové neutrality.
EU Contract Case Law, April–June 2024
Authors: Esposito Fabrizio , de Almeida Lucila , Grimolizzi Antonia 
Published: September 2024

Abstract
This article provides an overview of the most relevant cases decided by the Court of Justice of the European Union concerning contract law. The present issue covers the period between the beginning of April 2024 and the end of June 2024. Out of a total of 231 judgments decided in this period, 26 had a contract law dimension.
An efficient node selection algorithm in the context of IoT-based vehicular ad hoc network for emergency service
Authors: Mahdi Omar Adil , Eleiwy Jabbar Abed , Al-Mayouf Yusor Rafid Bahar , AL-Attar Bourair 
Published: September 2024

Abstract
With the recent growth of global populations, main roads in cities have witnessed an evident increase in the number of vehicles. This has led to unprecedented challenges for authorities in managing the traffic of ambulance vehicles to provide medical services in emergency cases. Despite the high technologies associated with medical tracks and advanced traffic management systems, there is still a current delay in ambulances’ attendance in times of emergency to provide patients with vital aid. Therefore, it is indispensable to introduce a new emergency service system that enables the ambulance to reach the patient in the least congested and shortest paths. However, designing an efficient algorithm to plan the best route for an ambulance is still a global goal and a challenge that needs to be solved. This article introduces an Internet of Things emergency services system based on a real-time node rank index (NR-index) algorithm to find the best route for the ambulance to reach the patient and provide the required medical services in emergency cases. The proposed system design copes with the dynamic traffic conditions to guarantee the shortest transport time. For this purpose, a vehicular ad hoc network is employed to collect accurate real-time traffic data. In this article, we suggest two parameters to compromise distance and congestion level. The first is the distance between the patient and the surrounding ambulance vehicles, and the second determines the congestion level to avoid the path with high congestion traffic. The system employs a developed real-time NR-index algorithm to select a suitable ambulance vehicle to respond to emergency cases at a low travel cost with the fastest journey. Finally, our system makes it easier for ambulance vehicles to use the best route and avoid heavy traffic. This allows them to make their way to the patient quickly and increases the chance of saving lives. The simulation results show significant improvements in terms of average travel time, average travel speed, and normalized routing load.
Anti-homophony and rhizotony in the Spanish preterite
Authors: Morris Richard E. 
Published: September 2024

AbstractSpeakers tend to avoid homophony that is problematic. While Spanish admits some homophony of 1SG and 3SG forms in three arrhizotonic tenses/moods (imperfect, past subjunctive, conditional), in two of the three rhizotonic tenses/moods (present indicative and preterite), the 1SG and 3SG contrast systematically. In the preterite, contrast (DĪXĪ ∼ DĪXIT) was lost in Old Spanish (dix[e] ∼ dix[e]) but subsequently restored (dije ∼ dijo). The developmentdix(e) > dijohas been attributed to analogical extension of arrhizotonic –o, (cf.amó), with destressing. This article proposes that said extension is the result of anti-homophony (AH). Like analogical extension, AH improves form-function isomorphism yet applies primarily to higher-frequency forms. It is argued that AH targeted 1SG ∼ 3SG homophony selectively, affecting only verb forms without an explicit tense/mood marker (e.g.,dixe ∼ dixevstenga ∼ tenga). This morphological restriction on AH explains why homophony persisted in four of the seven basic tenses (e.g.,tenga ∼ tenga,tenía ∼ tenía,tendría ∼ tendría,tuviera [–se] ∼ tuviera [–se]). The modern pairsfui ∼ fueanddi ∼ dio, which are the outcome of heavy competition, are shown to be a straightforward result of AH. In a broader perspective, the drive to distinguish 1SG and 3SG forms has brought about a “1–3 pattern” with a range similar to that of the N-pattern, in which stress is retained in certain paradigmatic cells in the absence of conditioning phonological factors. Destressing –oin forms likedijoandvinoserved to maintain the integrity of the 1–3 pattern as an organizing principle.
Enhanced stiffness characterization of load cells by relative change of the natural frequency forced by a defined mass shift
Authors: Wittke Martin , Darnieder Maximilian , Fröhlich Thomas , Theska René 
Published: September 2024

Abstract
High-precision force measurement systems such as mass comparators, balances, or tactile force sensors usually feature kinematic structures designed as compliant mechanisms. The applications require precise knowledge of the properties of the mechanism. Stiffness is critical here, as it has a major influence on measurement resolution and uncertainty. When implementing the manufactured mechanisms, it is necessary to consider that even small variations in the geometric and material properties result in significant deviations from the pre-calculated properties. An experimental characterization is therefore essential. However, the stiffness determination methods described by the state-of-the-art are either time-consuming or have a high uncertainty. For this reason, a time-saving, low-uncertainty method was developed. The approach is based on the determination of the natural frequency. To significantly reduce the measurement uncertainty compared to the existing natural frequency method, the absolute elastic stiffness value is characterized by the relative change in natural frequency when attaching a well-known mass. This reduces the uncertainty of the stiffness value by at least 75 %. This work includes the derivation of the method, the consideration of analytical and numerical models, and the experimental verification using two applications.
Soutenir les PME dans leurs enjeux de ressources humaines par le développement de coopératives d’employeurs : tensions et paradoxes durant la phase d’implantation
Authors: Robert-Huot Geneviève , Beaudin Marie-Claude , Audebrand Luc K. 
Published: September 2024

Devant les défis grandissants des PME en matière de main-d’œuvre, le Conseil québécois de la coopération et de la mutualité (CQCM) a conduit un projet ayant pour cible d’enrichir l’offre de soutien en gestion des ressources humaines (GRH). Ce projet devait soutenir la création de coopératives d’employeurs qui permettraient aux PME une prise en charge autonome et pérenne de leurs enjeux. Bien qu’aucune coopérative n’ait pu voir le jour au bout des trois années du projet, des apprentissages peuvent être tirés de cette démarche. Plus spécifiquement, des enjeux sont apparus en lien avec : 1) la traduction des fondements du projet auprès des acteurs concernés, 2) le diagnostic des besoins en RH propres à chaque organisation partenaire, 3) le jumelage des organisations, et 4) la définition de la raison d’être de la coopérative. Ces enjeux dévoilent les paradoxes sous-jacents à la complexité du projet.
Breast Biopsy Notification Preferences and Health Literacy
Authors: Fisher Manon , Ablah Elizabeth , Okut Hayrettin , Tenofsky Patty 
Published: September 2024

Introduction. Communication of breast biopsy results varies and does not always meet patient expectations. This study aimed to determine how patients previously diagnosed with breast cancer preferred to receive their biopsy results, including preferences for communication methods, the type of medical professional delivering the results, and wait time. Additionally, we evaluated how health literacy might affect these preferences.
Methods. English-speaking female patients who had previously been diagnosed with breast cancer were surveyed at a breast surgery clinic in Wichita, Kansas. The survey included the Brief Health Literacy Screen (BHLS), questions on how they received their biopsy results, and their preferences for receiving results. Participants were classified as having adequate or inadequate literacy based on their BHLS responses and a scoring system from previous research.
Results. The study included 101 participants. Overall, 64% preferred in-person communication, 40% preferred to hear from their primary care physician, 36% from their surgeon, and 56% wanted results within 24 hours. There was no statistically significant difference in preferences based on health literacy, including communication method (p = 0.44), type of medical professional (p = 0.56), and wait time (p = 0.38).
Conclusions. Most participants preferred to receive biopsy results indicating a breast cancer diagnosis in-person, regardless of their health literacy. While it may be sufficient to call a patient with benign biopsy results, it is recommended to offer an in-person discussion for cancer diagnoses, respecting the patient's preference.