bluuebunny/crossref_metadata_2025_split huggingface dataset:
Red blood cells for transfusion in patients with sepsis: respective roles of unit age and exposure to recipient plasma
Authors: Chadebech Philippe , Bodivit Gwellaouen , Razazi Keyvan , de Vassoigne Christophe , Pellé Laurence , Burin‐des‐Roziers Nicolas , Bocquet Thibault , Bierling Philippe , Djoudi Rachid , Mekontso‐Dessap Armand , Pirenne France 
Published: June 2017

BACKGROUNDRed blood cell (RBC) storage in blood banks is not exempt from cellular injury. Alterations not observed on RBCs freshly isolated from units can rapidly appear in circulation. The transfusion of old blood units, even if this is a controversial issue, could therefore have adverse effects on the recipient. We wanted to determine the respective effects of storage duration and recipient plasma on RBCs for transfusion into patients with severe sepsis.STUDY DESIGN AND METHODSEleven stored RBC units were sampled at various time points, approximately Days 3 to 8 (referred to as fresh RBCs) and Days 38 to 42 (old RBCs) and tested in coincubation experiments with plasma obtained from 13 patients with severe sepsis and 17 healthy donors as controls. RBCs were tested after 24 or 48 hours at 37°C for the detection of senescence markers (phosphatidylserine exposure, calcium influx, and reactive oxygen species detection and decrease in size) with or without exposure to plasma.RESULTSWe confirmed that a 42‐day refrigerated storage of RBCs alone (without any incubation in plasma) had no significant effect on RBCs and no senescence marker detected. By contrast, ex vivo exposure to plasma samples altered both fresh and old RBCs, with a much larger effect for old RBCs, regardless of the plasma used (sepsis vs. control).CONCLUSIONWe show that the main factor affecting the senescence of RBCs for transfusion into patients with severe sepsis is the age of the stored units rather than the clinical status of the recipient.
Reviewer Acknowledgements
Authors: Willianms Ellery 
Published: June 2017

Business and Management Studies (BMS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether BMS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 3, Number 2 Andrzej Niemiec, Poznań University of Economics and Business, PolandArash Riasi, University of Delaware, USAAshford Chea, Benedict College, USABashar Y. Almansour, Taibah University, JordanFlorin Peci, University of Peja, KosovoFouad Jawab, Universite Sidi Mohamed Ben, MoroccoGongyan Yang, Liaoning University, ChinaJayalakshmy Ramachandran, Multimedia University, MalaysiaKenichi Shimizu, Technical University of Braunschweig, GermanyKherchi Ishak, UHBC University, AlgeriaMarica Ion Dumitrasco, Academy of Sciences of Moldova, MoldovaMartin Sung, Hubei Economic and Finance University, ChinaMike Rayner, University of Portsmouth, UKMohammad Sadeghi, Universitat Politècnica de Catalunya, IranMohammad Soliman, Fayoum University, EgyptMythili Kolluru, Ibra College of Technology, OmanOmbretta Caldarice, Politecnico di Milano, ItalyOnur Dogan, Dokuz Eylül University, TurkeyRashedul Hasan, International Islamic University Malaysia, MalaysiaRegina Lenart-Gansiniec, Jagiellonian University, PolandRocsana Tonis, Spiru Haret University, RomaniaRuoniu Wang, University of Florida, USATaro Abe, Nagoya Gakuin University, JapanTetiana Paientko, National University of Tax Service of Ukraine, UkraineXhavit Islami, University of Prishtina, KosovoYang Zhao, Sanofi Genzyme, USAYanzhe Zhang, University of Canberra, AustraliaYao Liu, University Malaysia Pahang, MalaysiaZeki Atıl Bulut, Dokuz Eylul University, TurkeyZoran Mastilo, University of East Sarajevo, Bosnia and Herzegovina Ellery WillianmsEditorial AssistantOn behalf of,The Editorial Board of Business and Management StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://bms.redfame.com
Rapid Engineering of Foot-and-Mouth Disease Vaccine and Challenge Viruses
Authors: Lee Seo-Yong , Lee Yeo-Joo , Kim Rae-Hyung , Park Jeong-Nam , Park Min-Eun , Ko Mi-Kyeong , Choi Joo-Hyung , Chu Jia-Qi , Lee Kwang-Nyeong , Kim Su-Mi , Tark Dongseob , Lee Hyang-Sim , Ko Young-Joon , Seo Min-Goo , Park Jung-Won , Kim Byounghan , Lee Myoung-Heon , Lee Jong-Soo , Park Jong-Hyeon 
Published: June 2017

ABSTRACT
There are seven antigenically distinct serotypes of foot-and-mouth disease virus (FMDV), each of which has intratypic variants. In the present study, we have developed methods to efficiently generate promising vaccines against seven serotypes or subtypes. The capsid-encoding gene (P1) of the vaccine strain O1/Manisa/Turkey/69 was replaced with the amplified or synthetic genes from the O, A, Asia1, C, SAT1, SAT2, and SAT3 serotypes. Viruses of the seven serotype were rescued successfully. Each chimeric FMDV with a replacement of P1 showed serotype-specific antigenicity and varied in terms of pathogenesis in pigs and mice. Vaccination of pigs with an experimental trivalent vaccine containing the inactivated recombinants based on the main serotypes O, A, and Asia1 effectively protected them from virus challenge. This technology could be a potential strategy for a customized vaccine with challenge tools to protect against epizootic disease caused by specific serotypes or subtypes of FMDV.

IMPORTANCE
Foot-and-mouth disease (FMD) virus (FMDV) causes significant economic losses. For vaccine preparation, the selection of vaccine strains was complicated by high antigenic variation. In the present study, we suggested an effective strategy to rapidly prepare and evaluate mass-produced customized vaccines against epidemic strains. The P1 gene encoding the structural proteins of the well-known vaccine virus was replaced by the synthetic or amplified genes of viruses of seven representative serotypes. These chimeric viruses generally replicated readily in cell culture and had a particle size similar to that of the original vaccine strain. Their antigenicity mirrored that of the original serotype from which their P1 gene was derived. Animal infection experiments revealed that the recombinants varied in terms of pathogenicity. This strategy will be a useful tool for rapidly generating customized FMD vaccines or challenge viruses for all serotypes, especially for FMD-free countries, which have prohibited the import of FMDVs.
Effects of element doping on electronic structures and optical properties in cubic boron nitride from first-principles
Authors: Wei Yin , Wang Hongjie , Lu Xuefeng , Fan Xingyu , Wei Heng 
Published: June 2017

Attractive potential applications of cubic boron nitride (c-BN) derive from the properties of semiconductors, widely used in optoelectronic and microelectronic devices. In this paper, the effects of element doping on the electronic structures and optical properties in cubic boron nitride are investigated. The Al- and Ga-doped systems have the lower bonding energies of −11.544 eV and −5.302 eV, respectively, indicating better stability. Difference charge density maps demonstrate that the electron loss increases after P doping and decreases after Al, Ga and As dopings, indicating that the covalent character of polar covalent bonds decreases by doping in the range of P, Al, Ga and As, which is in accordance with the calculated atom population values. The Al- and Ga-doped systems show lower dielectric loss, absorption and reflectivity in the lower energy region, displaying the “transparent-type” characteristic and their potential applications in electron devices.
Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome
Authors: Kratz Christian P. , Achatz Maria Isabel , Brugières Laurence , Frebourg Thierry , Garber Judy E. , Greer Mary-Louise C. , Hansford Jordan R. , Janeway Katherine A. , Kohlmann Wendy K. , McGee Rose , Mullighan Charles G. , Onel Kenan , Pajtler Kristian W. , Pfister Stefan M. , Savage Sharon A. , Schiffman Joshua D. , Schneider Katherine A. , Strong Louise C. , Evans D. Gareth R. , Wasserman Jonathan D. , Villani Anita , Malkin David 
Published: June 2017

Abstract
Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited condition caused by germline mutations of the TP53 tumor suppressor gene encoding p53, a transcription factor triggered as a protective cellular mechanism against different stressors. Loss of p53 function renders affected individuals highly susceptible to a broad range of solid and hematologic cancers. It has recently become evident that children and adults with LFS benefit from intensive surveillance aimed at early tumor detection. In October 2016, the American Association for Cancer Research held a meeting of international LFS experts to evaluate the current knowledge on LFS and propose consensus surveillance recommendations. Herein, we briefly summarize clinical and genetic aspects of this aggressive cancer predisposition syndrome. In addition, the expert panel concludes that there are sufficient existing data to recommend that all patients with LFS be offered cancer surveillance as soon as the clinical or molecular LFS diagnosis is established. Specifically, the panel recommends adoption of a modified version of the “Toronto protocol” that includes a combination of physical exams, blood tests, and imaging. The panel also recommends that further research be promoted to explore the feasibility and effectiveness of these risk-adapted surveillance and cancer prevention strategies while addressing the psychosocial needs of individuals and families with LFS. Clin Cancer Res; 23(11); e38–e45. ©2017 AACR.
See all articles in the online-only CCR Pediatric Oncology Series.
Effect of Permanent Right Internal Mammary Artery Closure on Coronary Collateral Function and Myocardial Ischemia
Authors: Stoller Michael , Seiler Christian 
Published: June 2017

Background—
The objective of this study is to test the effect of permanent right internal mammary artery device closure on coronary collateral function and myocardial ischemia.

Methods and Results—

This was a prospective, open-label clinical trial in 50 patients with coronary artery disease. The primary study end point was coronary collateral flow index as obtained during a 1-minute proximal right coronary artery (RCA) and left coronary artery balloon occlusion at baseline before and at follow-up examination 6 weeks after distal right internal mammary artery device closure. Collateral flow index is the ratio between simultaneously recorded mean coronary occlusive pressure divided by mean aortic pressure, both subtracted by central venous pressure. Secondary study end points were fractional flow reserve during vessel patency, the quantitative intracoronary ECG ST-segment elevation, and angina pectoris during the same 1-minute coronary occlusion. Collateral flow index in the untreated RCA and left coronary artery changed from 0.071±0.082 at baseline to 0.132±0.117 (
P
<0.0001) at follow-up examination and from 0.106±0.092 to 0.081±0.079 (
P
=0.29), respectively. RCA fractional flow reserve increased significantly (
P
=0.0029) from baseline to follow-up examination, despite deferral of coronary intervention in all patients. There was a decrease in intracoronary ECG ST-elevation during RCA occlusion from baseline to follow-up examination (
P
=0.0015); it did not change in the left coronary artery. Angina pectoris during RCA occlusion tended to occur in fewer patients at follow-up versus baseline examination (
P
=0.06).

Conclusions—
Permanent right internal mammary artery device closure seems to augment extracardiac ipsilateral coronary supply to the effect of reducing ischemia in the dependent myocardial region.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT02475408.
Systematic Review of the Outcomes of Surgical Treatment of Prostate Metastases to the Spine
Authors: Clarke Michelle J. , Molina Camilo A. , Fourney Daryl R. , Fisher Charles G. , Gokaslan Ziya L. , Schmidt Meic H. , Rhines Laurence D. , Fehlings Michael G. , Laufer Ilya , Patel Shreyaskumar R. , Rampersaud Y. Raja , Reynolds Jeremy , Chou Dean , Bettegowda Chetan , Mendel Ehud , Weber Michael H. , Sciubba Daniel M. 
Published: June 2017

Study Design: Systematic review. Objective: Surgical decompression and reconstruction of symptomatic spinal metastases has improved the quality of life in cancer patients. However, most data has been collected on cohorts of patients with mixed tumor histopathology. We systematically reviewed the literature for prognostic factors specific to the surgical treatment of prostate metastases to the spine. Methods: A systemic review of the literature was conducted to answer the following questions: Question 1. Describe the survival and functional outcomes of surgery or vertebral augmentation for prostate metastases to the spine. Question 2. Determine whether overall tumor burden, Gleason score, preoperative functional markers, and hormonal naivety favor operative intervention. Question 3. Establish whether clinical outcomes vary with the evolution of operative techniques. Results: A total of 16 studies met the preset inclusion criteria. All included studies were retrospective series with a level of evidence of IV. Included studies consistently showed a large effect of hormone-naivety on overall survival. Additionally, studies consistently demonstrated an improvement in motor function and the ability to maintain/regain ambulation following surgery resulting in moderate strength of recommendation. All other parameters were of insufficient or low strength. Conclusions: There is a dearth of literature regarding the surgical treatment of prostate metastases to the spine, which represents an opportunity for future research. Based on existing evidence, it appears that the surgical treatment of prostate metastases to the spine has consistently favorable results. While no consistent preoperative indicators favor nonoperative treatment, hormone-naivety and high Karnofsky performance scores have positive effects on survival and clinical outcomes.
Estado de juízes: aquele jardim, no Inferno
Authors: Grau Eros Roberto 
Published: June 2017

O artigo contesta, com base na lei, decisões judiciais que absolveram casos de aborto e, assim, desrespeitaram e invadiram questões do Legislativo e da Constituição. O autor questiona, em específico, a legalização ou absolvição do aborto em caso de feto anencéfalo. The article questions, based on law, some court decisions that absorbed abortion cases and, thus, disrespected and invaded legislative and constitutional matters. The author questions, specifically, the legalization or absolution of the abortion in cases of Anencephalic fetus.
EXPERIMENTAL VERIFICATION OF NEW METHODOLOGY FOR CALCULATING OF THE FLEXIBLE FERROCONCRETE FOUNDATION OF THE FIRST LIMIT STATE
Authors: Дыба Владимир , Dyba Vladimir , Матвиенко Максим 
Published: June 2017

The article discusses the problem of discrepancy of
normative methods for calculating the bearing capacity of foundations
experimental data. The authors proposed a new method
of calculation of flexible ferroconcrete foundation, which can
eliminate a large gap between the calculated and experimental
data. The article describes an experiment on a sandy base, and
its results, confirming the new methodology. The use of bilinear
limit line τ (σ) for the calculation of the strength characteristics
of dense sandy ground is describes.
Lesson in Russian Language in the Third Grade
Authors: Ожогина  , Ozhogina N. 
Published: June 2017

The article considers features of the technique of developing training of younger schoolchildren on an example of carrying out of a lesson in Russian on the theme « Animate and inanimate nouns». There tasks are presented in the course of which children’s knowledge on the basis of observation of linguistic units not only form the subject knowledge about the animate and inanimate nouns, but also the formation of universal
educational activities.
The Role of Surge Pricing on a Service Platform with Self-Scheduling Capacity
Authors: Cachon Gérard P. , Daniels Kaitlin M. , Lobel Ruben 
Published: June 2017

Recent platforms, like Uber and Lyft, offer service to consumers via “self-scheduling” providers who decide for themselves how often to work. These platforms may charge consumers prices and pay providers wages that both adjust based on prevailing demand conditions. For example, Uber uses a “surge pricing” policy, which pays providers a fixed commission of its dynamic price. With a stylized model that yields analytical and numerical results, we study several pricing schemes that could be implemented on a service platform, including surge pricing. We find that the optimal contract substantially increases the platform’s profit relative to contracts that have a fixed price or fixed wage (or both), and although surge pricing is not optimal, it generally achieves nearly the optimal profit. Despite its merits for the platform, surge pricing has been criticized because of concerns for the welfare of providers and consumers. In our model, as labor becomes more expensive, providers and consumers are better off with surge pricing because providers are better utilized and consumers benefit both from lower prices during normal demand and expanded access to service during peak demand. We conclude, in contrast to popular criticism, that all stakeholders can benefit from the use of surge pricing on a platform with self-scheduling capacity. The e-companion is available at https://doi.org/10.1287/msom.2017.0618 .
An O(log n/log log n)-Approximation Algorithm for the Asymmetric Traveling Salesman Problem
Authors: Asadpour Arash , Goemans Michel X. , Mądry Aleksander , Gharan Shayan Oveis , Saberi Amin 
Published: June 2017

We present a randomized O(log n/log log n)-approximation algorithm for the asymmetric traveling salesman problem (ATSP). This provides the first asymptotic improvement over the long-standing Θ(log n)-approximation bound stemming from the work of Frieze et al. (1982) [Frieze AM, Galbiati G, Maffioki F (1982) On the worst-case performance of some algorithms for the asymmetric traveling salesman problem. Networks 12(1):23–39]. The key ingredient of our approach is a new connection between the approximability of the ATSP and the notion of so-called thin trees. To exploit this connection, we employ maximum entropy rounding—a novel method of randomized rounding of LP relaxations of optimization problems. We believe that this method might be of independent interest.
Femoral neck fractures in osteogenesis imperfecta treated with bisphosphonates
Authors: Papanna M. C. , Tafazal S. , Bell M. J. , Giles S. N. , Fernandes J. A. 
Published: June 2017

Purpose Osteogenesis imperfecta (OI) is a condition characterised by bone fragility and multiple fractures, which cause considerable morbidity in the affected patients. Most cases are associated with mutations in one of the type I collagen genes. Recently, bisphosponates have been used widely to reduce pain and the incidence of fragility fractures in OI in children, even though there have been concerns raised regarding the long-term complications of it due to their effect on the bone. The fragility fractures involving the neck of the femur in children with intramedullary rods in the femoral shaft are very difficult to treat. Although these fractures are frequently un-displaced, they require optimal internal fixation to achieve fracture union. The aim of this study was to assess the clinical and radiological outcomes of OI patients with intracapsular femoral neck fracture treated with headless compression screws. Method and results At our institute, we identified seven patients (11 hips) with OI who underwent internal fixation with headless compression screws for a neck of femur fracture between June 2010 and Dec 2012. The time to fractures healing was on average 14 weeks (12 to 16). All patients gained their pre-injury ambulatory status. Conclusion It is very challenging and technically demanding for orthopaedic surgeons when treating the fragility fracture of the neck of femur in patients with intramedullary rod in the femoral shaft. The published data regarding the management of these complex conditions are very limited. We describe our experience with the technique of percutaneous headless compression screw fixation for treating the femoral neck fractures in OI patients.
Entre a escrita e a pele: a dramaturgia confessional e a encenação de Angélica Liddell redimensionados em devir
Authors: Ferraz Mirela Ferreira 
Published: June 2017

Ao considerar a escrita teatral como ponto nevrálgico do teatro contemporâneo, esse artigo propõe trabalhar com a ideia de uma ligação contínua presente entre a escrita confessional e a encenação na obra “Yo no soy bonita” de Angélica Liddell. Acredita-se que o espetáculo e a língua da autora, encenadora e atriz/performer tornam-se diluídas no próprio acontecimento teatral, em que a ideia de um “devir-cênico” estabelece-se como um dispositivo cênico das novas teatralidades. Analisa-se como a noção de “eu” da artista se mescla ao desfalecimento da ideia de um personagem, criando uma zona de fronteiriça entre o teatro e a performance art, a qual se evidencia pela busca de uma possível experiência-limite da artista.

ABSTRACT
When considering the theatrical writing as nerve center of contemporary theater, this article proposes working with the idea of a continuous link between the present confessional writing and staging the Angélica Liddell work "Yo no soy bonita". It is believed that the show and the language of the author, stage director and actress / performer become diluted in their own theatrical event, in which the idea of "becoming-scenic" is established as a scenic device of new theatrics. It is analyzed how the notion of "I" of the artist melds the faintness of the idea of a character, creating a border zone between theater and performance art, which is evidenced by the search for a possible artist of limit-experience.

KEYWORDS
Becoming- scenic; confessional writing; limit-experience; contemporary theater.