bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial
Authors: Pers Yves-Marie , Rackwitz Lars , Ferreira Rosanna , Pullig Oliver , Delfour Christophe , Barry Frank , Sensebe Luc , Casteilla Louis , Fleury Sandrine , Bourin Philippe , Noël Danièle , Canovas François , Cyteval Catherine , Lisignoli Gina , Schrauth Joachim , Haddad Daniel , Domergue Sophie , Noeth Ulrich , Jorgensen Christian ,   on behalf of the ADIPOA Consortium
Published: May 2016

Abstract

Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study aimed at evaluating the safety of a dose-escalation protocol of intra-articular injected adipose-derived stromal cells (ASCs) in patients with knee OA, as well as clinical efficacy as secondary endpoint. A bicentric, uncontrolled, open phase I clinical trial was conducted in France and Germany with regulatory agency approval for ASC expansion procedure in both countries. From April 2012 to December 2013, 18 consecutive patients with symptomatic and severe knee OA were treated with a single intra-articular injection of autologous ASCs. The study design consisted of three consecutive cohorts (six patients each) with dose escalation: low dose (2 × 106 cells), medium dose (10 × 106), and high dose (50 × 106). The primary outcome parameter was safety evaluated by recording adverse events throughout the trial, and secondary parameters were pain and function subscales of the Western Ontario and McMaster Universities Arthritis Index. After 6 months of follow-up, the procedure was found to be safe, and no serious adverse events were reported. Four patients experienced transient knee joint pain and swelling after local injection. Interestingly, patients treated with low-dose ASCs experienced significant improvements in pain levels and function compared with baseline. Our data suggest that the intra-articular injection of ASCs is a safe therapeutic alternative to treat severe knee OA patients. A placebo-controlled double-blind phase IIb study is being initiated to assess clinical and structural efficacy.

Significance
Although this phase I study included a limited number of patients without a placebo arm, it showed that local injection of autologous adipose-derived stem cells was safe and well tolerated in patients with knee osteoarthritis. This study also provides encouraging preliminary evidence of efficacy. Larger and controlled long-term studies are now mandatory to confirm whether this new strategy of cell therapy can improve pain and induce structural benefit in osteoarthritis.
The Permian Basin Programmatic Agreement after Seven Years of Implementation
Authors: Larralde Signa , Stein Martin , Schlanger Sarah H. 
Published: May 2016

AbstractThe Permian Basin Programmatic Agreement (PA) is an alternative form of Section 106 compliance offered mainly to the oil and gas industry in southeastern New Mexico for projects located on Bureau of Land Management (BLM) land. Proponents of projects within the PA area may contribute to a dedicated archaeological research fund in lieu of contracting for project specific archaeological surveys, provided their proposed projects avoid recorded archaeological sites. Dedicated funding goes toward research on the archaeology and history of southeastern New Mexico. The PA calls for the consulting parties to evaluate its effectiveness during its seventh year of implementation. As a result of that recent evaluation in May 2015, the PA will be extended for 10 additional years. We discuss the reasons for the PA, successes and missteps during its first seven years, and ways that the Permian Basin PA might be used as a model elsewhere.
Dusting Off the Data
Authors: MacFarland Kathryn , Vokes Arthur W. 
Published: May 2016

AbstractArchaeological projects that are described as orphaned or legacy collections are generally older materials that do not meet modern “best practice” curation standards and require considerable resources to be preserved for future research. Rehabilitation and curation of these projects allows for better inventory control of the artifacts, and accompanying documentation ensures that cultural heritage is preserved and plays an important part in the repatriation process. Procedures and methods for rehousing archaeological legacy collections are outlined. Using the 1984–1987 Arizona Archaeological and Historical Society (AAHS) volunteer excavations at Redtail Village (AZ AA:12:149 [ASM]) as a case study, we propose a process for rehabilitating legacy collections and offer solutions for preserving important archaeological resources for future research.
Pushing the Paperless Envelope
Authors: E. Jackson Sarah , F. Motz Christopher , A. Brown Linda 
Published: May 2016

AbstractArchaeological documentation is in the midst of a technological shift as recording systems transition from paper-based forms to digital formats. Digital systems effectively replicate the information recorded on paper forms, while also offering recording advantages for archaeologists in the field. In addition to such logistical contributions to archaeological workflows, digital technology also has tremendous potential to transform the ways that archaeology is done by shifting how we see our sites, and how we document them through diverse data types. With the goal of exploring this potential, we developed a tablet-based relational database, using FileMaker, which provides the ability to simultaneously record specific characteristics of artifacts and features according to two cultural perspectives—modern archaeological understandings and also those of the Classic Maya. In this article, we describe the database and discuss the results of a pilot field season using the database to record excavations at the site of Say Kah, Belize. Our experiences yield several broader reflections on the impact of using digital recording systems both for practical advantage and for productive shifts in perception.
Falling through the gaps: how should HIV programmes respond to families that persistently deny treatment to children?
Authors: Busza Joanna , Strode Ann , Dauya Ethel , Ferrand Rashida A 
Published: May 2016

IntroductionChildren living with HIV rely on adult caregivers for access to HIV testing and care, including clinical monitoring and adherence to treatment. Yet, many caregivers confront barriers to ensuring children's care, including fear of disclosure of the child's or the parents’ HIV status, competing family demands, fluctuating care arrangements and broader structural factors such as entrenched poverty or alternative beliefs about HIV's aetiology and treatment. Thus, many children are “falling through the gaps” because their access to testing and care is mediated by guardians who appear unable or unwilling to facilitate it. These children are likely to suffer treatment failure or death due to their caregivers’ recalcitrance.DiscussionThis Commentary presents three cases from paediatric HIV services in Zimbabwe that highlight the complexities facing health care providers in providing HIV testing and care to children, and discusses the implications as a child's rights issue requiring both legal and programmatic responses. The cases provide examples of how disagreements between family members about appropriate care, conflicts between a child and caregiver and religious objections to medical treatment interrupt children's engagement with HIV services. In all three cases, no social or legal mechanisms were in place for health staff to intervene and prevent “loss to follow up.”ConclusionsWe suggest that conceptualizing this as a child's rights issue may be a useful way to raise the debate and move towards improved treatment access. Our cases reflect policy failure to facilitate access to children's HIV testing and treatment, and are likely to be similar across international settings. We propose sharing experiences and encouraging dialogue between health practitioners and global advocates for children's right to health to raise awareness that children are the bearers of rights even if they lack legal capacity, and that the failure of either the state or their caregiver to facilitate access to care is in fact a rights violation.
Understanding Global Crises
Authors: Razin Assaf 
Published: May 2016

A historical and theoretical investigation of the “common storylines” of recent financial crises.
Financial crises have some common storylines, among them bursting asset bubbles, bank failures, sharp tightening of credit, and downturn in trade. They are also different from one another. Some start with sudden reversal of international capital flows, others with domestic credit implosions. A challenge to economic research is to integrate common as well as disparate threads into a coherent analytical framework that is at the same time empirically testable. In Understanding Global Crises, Assaf Razin offers a review of an emerging paradigm that is consistent with the key features of recent global financial crises. This paradigm presents in a transparent way basic analytical elements of the theories of financial and monetary crises and how these elements fit together in macroeconomic analysis of global crises.
Razin surveys the credit implosion that led to a severe banking crisis in Japan in the 1990s, the Asian financial crisis that began in 1997, the global meltdown of 2008, and the Euro-zone crisis. He reviews the analytics of financial fragilities, credit frictions, currency crises, and balance of payments crises, and addresses international capital flows with information frictions. He then presents key developments in the New Keynesian analytical framework by examining the surge of re-modeling efforts aimed at the development of an analytical framework to underpin monetary and fiscal policy in the post-2008 economic era.
A Prehistory of the Cloud
Authors: Hu Tung-Hui 
Published: May 2016

The militarized legacy of the digital cloud: how the cloud grew out of older network technologies and politics.
We may imagine the digital cloud as placeless, mute, ethereal, and unmediated. Yet the reality of the cloud is embodied in thousands of massive data centers, any one of which can use as much electricity as a midsized town. Even all these data centers are only one small part of the cloud. Behind that cloud-shaped icon on our screens is a whole universe of technologies and cultural norms, all working to keep us from noticing their existence. In this book, Tung-Hui Hu examines the gap between the real and the virtual in our understanding of the cloud.
Hu shows that the cloud grew out of such older networks as railroad tracks, sewer lines, and television circuits. He describes key moments in the prehistory of the cloud, from the game “Spacewar” as exemplar of time-sharing computers to Cold War bunkers that were later reused as data centers. Countering the popular perception of a new “cloudlike” political power that is dispersed and immaterial, Hu argues that the cloud grafts digital technologies onto older ways of exerting power over a population. But because we invest the cloud with cultural fantasies about security and participation, we fail to recognize its militarized origins and ideology. Moving between the materiality of the technology itself and its cultural rhetoric, Hu's account offers a set of new tools for rethinking the contemporary digital environment.
Control
Authors: Franklin Seb 
Published: May 2016

An examination of digitality not simply as a technical substrate but also as the logical basis for reshaped concepts of labor, subjectivity, and collectivity.
Is there a cultural logic of what we have come to call the information age? Have the technologies and techniques centered on the computer provided not only tools but also the metaphors through which we now understand the social and economic formation of our world? In Control, Seb Franklin addresses the conditions of knowledge that make the concept of the “information economy” possible while at the same time obscuring its deleterious effects on material social spaces. In so doing, Franklin traces three intertwined threads: the relationships among information, labor, and social management that emerged in the nineteenth century; the mid-twentieth-century diffusion of computational metaphors; and the appearance of informatic principles in certain contemporary socioeconomic and cultural practices.
Drawing on critical theory, media theory, and the history of science, Franklin names control as the episteme grounding late capitalism. Beyond any specific device or set of technically mediated practices, digitality functions within this episteme as the logical basis for reshaped concepts of labor, subjectivity, and collectivity, as well as for the intensification of older modes of exclusion and dispossession. In tracking the pervasiveness of this logical mode into the present, Franklin locates the cultural traces of control across a diverse body of objects and practices, from cybernetics to economic theory and management styles, and from concepts of language and subjectivity to literary texts, films, and video games.
Power in a Warming World
Authors: Ciplet David , Roberts J. Timmons , Khan Mizan R. 
Published: May 2016

An examination of shifting global power dynamics in climate change politics, and how this affects our ability to achieve equitable and sustainable climate outcomes.
After nearly a quarter century of international negotiations on climate change, we stand at a crossroads. A new set of agreements is likely to fail to prevent the global climate's destabilization. Islands and coastlines face inundation, and widespread drought, flooding, and famine are expected to worsen in the poorest and most vulnerable countries. How did we arrive at an entirely inequitable and scientifically inadequate international response to climate change?
In Power in a Warming World, David Ciplet, J. Timmons Roberts, and Mizan Khan, bring decades of combined experience as negotiators, researchers, and activists to bear on this urgent question. Combining rich empirical description with a political economic view of power relations, they document the struggles of states and social groups most vulnerable to a changing climate and describe the emergence of new political coalitions that take climate politics beyond a simple North-South divide. They offer six future scenarios in which power relations continue to shift as the world warms. A focus on incremental market-based reform, they argue, has proven insufficient for challenging the enduring power of fossil fuel interests, and will continue to be inadequate without a bolder, more inclusive and aggressive response.
Correlation of Somatic Dysfunction With Gastrointestinal Endoscopic Findings: An Observational Study
Authors: Snider Karen T. , Schneider Robert P , Snider Eric J. , Danto Jay B. , Lehnardt Charles W. , Ngo Christopher S. , Johnson Jane C. , Sheneman Timothy A. 
Published: May 2016

Abstract

Context: Gastrointestinal (GI) endoscopy provides a novel means of correlating visceral abnormalities with somatic dysfunction.

Objective: To assess the correlation of palpatory findings of somatic dysfunction with GI abnormalities determined by endoscopy and to identify which types of somatic dysfunction were most commonly correlated with GI abnormalities.

Methods: In this observational, cross-sectional study, participants who were scheduled to receive an esophagogastroduodenoscopy (EGD), colonoscopy, or both were examined by 2 osteopathic physicians immediately prior to endoscopy for the presence of vertebral tenderness, asymmetry, restricted range of motion, and tissue texture abnormalities (TART findings); tenderness of anterior Chapman reflex points; and tenderness of visceral sphincters. Each type of somatic dysfunction and the somatic dysfunction burden (sum of findings) were compared with the type of endoscopic procedure and abnormal endoscopic findings.

Results: Sixty-six adults participated: 43 received an EGD, 40 received a colonoscopy, and 17 received both. The incidence of vertebral TART findings ranged from 70% at T12 to 98% at the sacrum. Participants who received only EGD had a higher somatic dysfunction burden than those who received only colonoscopy and those who received both procedures (P=.002). The incidence of abnormal endoscopic findings ranged from 98% in the stomach to 0% at the ileocecal valve. Statistically significant positive associations were found between specific vertebral TART findings and abnormalities of the esophagus, gastroesophageal junction, pylorus, ascending colon, and sigmoid colon; specific Chapman reflex point tenderness and abnormalities of the esophagus, gastroesophageal junction, pylorus, ascending colon, descending colon, sigmoid colon, and rectum; and specific visceral sphincter tenderness and abnormalities of the duodenum, ascending colon, and sigmoid colon.

Conclusions: The current study found numerous associations between somatic dysfunction and abnormal endoscopic findings. However, the high incidence of vertebral TART findings and the lack of normal controls for many GI regions made establishing meaningful relationships between specific somatic dysfunction and specific GI abnormalities challenging. Future investigations should include more participants to ensure a higher number of normal endoscopic findings and limit the physical examination to elements of somatic dysfunction with a high level of variability between vertebrae within an individual participant and between participants, such as tenderness and tissue texture abnormalities. (ClinicalTrials.gov number NCT01394198)
Disseminated Varicella-Zoster Virus After Vaccination in an Immunocompetent Patient
Authors: Scotch Allison H. , Hoss Elika , Orenstein Robert , Budavari Adriane I. 
Published: May 2016

Abstract
Severe adverse events associated with varicella-zoster virus (VZV) vaccination are rare. The authors describe a 53-year-old woman with no known immunodeficiency who presented with diffuse pruritic rash 17 days after receiving the varicella virus vaccine live. She had a low level of white blood cells and received a diagnosis of thrombocytopenia with elevated aminotransferase levels. Punch biopsy demonstrated positive VZV immunostaining and viral culture positive for VZV. After treatment with acyclovir, her rash improved and her white blood cell and platelet counts returned to normal. Mild reactions to vaccines including localized rash are well recognized. Disseminated infections have been reported in patients with congenital and acquired immunodeficiency, but systemic postvaccination infections are rare in immunocompetent adults. This case highlights the importance of recognizing adverse events associated with vaccination.
Superior transport properties of InGaN channel heterostructure with high channel electron mobility
Authors: Zhang Yachao , Zhou Xiaowei , Xu Shengrui , Zhang Jinfeng , Zhang Jincheng , Hao Yue 
Published: May 2016

Abstract
A high-quality AlGaN/InGaN heterostructure is grown by pulsed metal organic chemical vapor deposition on a sapphire substrate. A two-step AlN interlayer is adopted to improve the interface morphology and protect the high-quality InGaN channel. Temperature-dependent Hall measurement shows superior transport properties compared with the traditional GaN channel heterostructure at elevated temperatures. Further, a record highest channel electron mobility of 1681 cm2/(V·s) at room temperature for an InGaN channel heterostructure is obtained. We attribute the excellent transport properties to the improvement in the material quality, as well as the rationally designed epitaxial structure and well-controlled growth condition.
Direct observation of infinite NiO2 planes in LaNiO2 films
Authors: Ikeda Ai , Krockenberger Yoshiharu , Irie Hiroshi , Naito Michio , Yamamoto Hideki 
Published: May 2016

Abstract
Epitaxial thin films of LaNiO2, which is an oxygen-deficient perovskite with “infinite layers” of Ni1+O2, were prepared by a low-temperature reduction of LaNiO3 single-crystal films on NdGaO3 substrates. We report the high-angle annular dark-field and bright-field scanning transmission electron microscopy observations of infinite NiO2 planes of c-axis-oriented LaNiO2 epitaxial thin films with a layer stacking sequence of NiO2/La/NiO2. Resistivity measurements on the films show T
2 dependence between 400 and 150 K and a negative Hall coefficient.
Control of carrier lifetime of thick n-type 4H-SiC epilayers by high-temperature Ar annealing
Authors: Saito Eiji , Suda Jun , Kimoto Tsunenobu 
Published: May 2016

Abstract
We investigated the carrier lifetime and Z1/2 center density of thick n-type 4H-SiC epilayers, which were oxidized and subsequently annealed in Ar at high temperatures. The Z1/2 center density decreased below the detection limit in the region to, at least, a 130 µm depth by thermal oxidation. After subsequent high-temperature annealing, the Z1/2 center density increased with increasing annealing temperature, while the distribution of the Z1/2 center density was nearly uniform to a 130 µm depth. The carrier lifetime could be controlled from 26 to 2.4 µs by changing the annealing temperature from 1600 to 1800 °C.
Surface plasmon-enhanced optical trapping of quantum-dot-conjugated surface molecules on neurons cultured on a plasmonic chip
Authors: Miyauchi Kohei , Tawa Keiko , Kudoh Suguru N. , Taguchi Takahisa , Hosokawa Chie 
Published: May 2016

Abstract
Living neurons in a complex neuronal network communicate with each other through synaptic connections. The molecular dynamics of cell surface molecules localized at synaptic terminals is essential for functional connections via synaptic plasticity in the neuronal network. Here, we demonstrate surface-plasmon-resonance-based optical trapping using a plasmonic chip toward realizing effective manipulation of molecules on the surface of neurons. Surface-plasmon-enhanced optical trapping was evaluated by the fluorescence analysis of nanoparticles suspended in water and neural cell adhesion molecules (NCAMs) labeled with quantum dots (Q-dots) on rat hippocampal neurons. The motion of nanoparticles in water and the molecular dynamics of NCAMs on neuronal cells cultured on a plasmonic chip were constrained at the laser focus more effectively than those on a glass substrate because of the surface plasmon resonance effect.
Spontaneous reduction of an incarcerated gravid uterus in the third trimester
Authors: Takami Mio , Hasegawa Yoshimi , Seki Kazuo , Hirahara Fumiki , Aoki Shigeru 
Published: May 2016

Key Clinical MessageAn incarcerated gravid uterus is an uncommon complication of pregnancy. On rare occasions, an incarcerated gravid uterus resolves spontaneously even in the third trimester of pregnancy. Severe abdominal pain might be caused by spontaneous reduction and should be considered as a possible cause.
ChemInform Abstract: New Complex Fluorides with Ag2+ and Pd2+: NaM(II)Zr2F11 (M(II): Ag, Pd) and AgPdZr2F11.
Authors: MUELLER B. G. + 
Published: May 2016

AbstractSingle crystal XRD data show that the isotypic compounds NaAgZr2F11 and NaPdZr2F11 crystallize in the triclinic space group P1 with Z=1.
ChemInform Abstract: Ion Exchange in Alkali Layers of Potassium β‐Ferrite ((1 + x)K2O·11 Fe2O3) Single Crystals.
Authors: ITO S. , KUBO N. , NARIKI S. , YONEDA N. 
Published: May 2016

AbstractIt is demonstrated that K+ in potassium β‐ferrite crystals can be exchanged by M+: Na+, Rb+, Cs+, Ag+, NH4+, H3O+ to form M+ β‐ferrites without rearrangement of the spinel blocks of the β‐structure (ion‐exchange in molten nitrates or conc.
ChemInform Abstract: Activated Ligand Substitution in Bridged Complexes. Part 2. Base Hydrolysis of the (μ‐Amido)decaamminedicobalt(5+) Ion. Synthesis and Structure of the (μ‐Amido)chloroenneaamminedicobalt(4+) Ion.
Authors: ROTZINGER F. P. , MUELLER E. + , MARTY W. 
Published: May 2016

AbstractThe deprotonation of the (μ‐amido)decaamminedicobalt(III) ion (I) is followed by rapid NH3 loss yielding the intermediate (III).