bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blueprints of Architected Materials: A Guide to Metamaterial Design for Tissue Engineering
Authors: Kalogeropoulou Maria , Kracher Anna , Fucile Pierpaolo , Mihăilă Silvia M. , Moroni Lorenzo 
Published: October 2024

AbstractMechanical metamaterials are rationally designed structures engineered to exhibit extraordinary properties, often surpassing those of their constituent materials. The geometry of metamaterials’ building blocks, referred to as unit cells, plays an essential role in determining their macroscopic mechanical behavior. Due to their hierarchical design and remarkable properties, metamaterials hold significant potential for tissue engineering; however their implementation in the field remains limited. The major challenge hindering the broader use of metamaterials lies in the complexity of unit cell design and fabrication. To address this gap, a comprehensive guide is presented detailing the design principles of well‐established metamaterials. The essential unit cell geometric parameters and design constraints, as well as their influence on mechanical behavior, are summarized highlighting essential points for effective fabrication. Moreover, the potential integration of artificial intelligence techniques is explored in meta‐biomaterial design for patient‐ and application‐specific design. Furthermore, a comprehensive overview of current applications of mechanical metamaterials is provided in tissue engineering, categorized by tissue type, thereby showcasing the versatility of different designs in matching the mechanical properties of the target tissue. This review aims to provide a valuable resource for tissue engineering researchers and aid in the broader use of metamaterials in the field.
A Robust Core‐Shell Nanofabric with Personal Protection, Health Monitoring and Physical Comfort for Smart Sportswear
Authors: Wu Peiqi , Gu Jianfeng , Liu Xue , Ren Yichen , Mi Xiaoqian , Zhan Weiqing , Zhang Xinmin , Wang Huihui , Ji Xinyi , Yue Zhao , Liang Jiajie 
Published: October 2024

AbstractSmart textiles with a high level of personal protection, health monitoring, physical comfort, and wearing durability are highly demanded in clothing for harsh application scenarios, such as modern sportswear. However, seamlessly integrating such a smart clothing system has been a long‐sought but challenging goal. Herein, based on coaxial electrospinning techniques, a smart non‐woven textile (Smart‐NT) integrated with high impact resistance is developed, multisensory functions, and radiative cooling effects. This Smart‐NT is comprised of core‐shell nanofibers with an ionic conductive polymer sheath and an impact‐stiffening polymer core. The soft smart textile, with a thickness of only 800 µm, can attenuate over 60% of impact force, sense pressure stimulus with sensitivity up to 201.5 kPa−1, achieve temperature sensing resolution of 0.1 °C, and reduce skin temperature by ≈17 °C under a solar intensity of 1 kW m−2. In addition, the stretchable Smart‐NT is highly durable and robust, retaining its multifunction features over 10 000 bending and multiple washing cycles. Finally, application scenarios are demonstrated for real‐time health monitoring, body protection, and physical comfort of smart sportswear based on Smart‐NT for outdoor sports. The strategy opens a new avenue for seamless integration of smart clothing systems.
Anode‐Free Li Metal Batteries: Feasibility Analysis and Practical Strategy
Authors: Huo Sida , Wang Li , Su Ben , Xue Wendong , Wang Yue , Zhang Hao , Li Meng , Qiu Jingyi , Xu Hong , He Xiangming 
Published: October 2024

AbstractEnergy storage devices are striving to achieve high energy density, long lifespan, and enhanced safety. In view of the current popular lithiated cathode, anode‐free lithium metal batteries (AFLMBs) will deliver the theoretical maximum energy density among all the battery chemistries. However, AFLMBs face challenges such as low plating‐stripping efficiency, significant volume change, and severe Li‐dendrite growth, which negatively impact their lifespan and safety. This study provides an overview and analysis of recent progress in electrode structure, characterization, performance, and practical challenges of AFLMBs. The deposition behavior of lithium is categorized into two stages: heterogeneous and homogeneous interface deposition. The feasibility and practical application value of AFLMBs are critically evaluated. Additionally, key test models, evaluation parameters, and advanced characterization techniques are discussed. Importantly, practical strategies of different battery components in AFLMBs, including current collector, interface layer, solid‐state electrolyte, liquid‐state electrolyte, cathode, and cycling protocol, are presented to address the challenges posed by the two types of deposition processes, lithium loss, crosstalk effect and volume change. Finally, the application prospects of AFLMBs are envisioned, with a focus on overcoming the current limitations and unlocking their full potential as high‐performance energy storage solutions.
A Dynamic H‐Bonding Network Enables Stimuli‐Responsive Color‐Tunable Chiral Afterglow Polymer for 4D Encryption
Authors: Guo Guangyao , Li Huanhuan , Yan Yingmeng , Zhao Wei , Gao Zhisheng , Cao Hengyu , Yan Xin , Li Hui , Xie Gaozhan , Chen Runfeng , Tao Ye , Huang Wei 
Published: October 2024

AbstractThe development of stimuli‐responsive and color‐tunable chiral organic afterglow materials has attracted great attention but remains a daunting challenge. Here, a simple yet effective strategy through the construction of a dynamic H‐bonding network is proposed to explore the multi‐color stimuli‐responsive chiral afterglow by doping a self‐designed chiral phosphorescent chromophore into a polyvinyl alcohol matrix. A stimuli‐responsive deep blue chiral afterglow system with a lifetime of up to 3.35 s, quantum yield of 25.0%, and luminescent dissymmetry factor of up to 0.05 is achieved through reversible formation and breakdown of the H‐bonding network upon thermal‐heating and water‐fumigating. Moreover, multi‐color stimuli‐responsive chiral afterglow can be obtained by chiral and afterglow energy transfer, allowing the establishment of afterglow information displays and high‐level 4D encryption. This work not only offers a facile platform to develop advanced stimuli‐responsive materials but also opens a new avenue for developing next‐generation optical information technology with enhanced functionality and responsiveness.
NIR‐Actuated Ferroptosis Nanomotor for Enhanced Tumor Penetration and Therapy
Authors: Hu Ziwei , Tan Haixin , Ye Yicheng , Xu Wenxin , Gao Junbin , Liu Lu , Zhang Lishan , Jiang Jiamiao , Tian Hao , Peng Fei , Tu Yingfeng 
Published: October 2024

AbstractFerroptosis nano‐inducers have drawn considerable attention in the treatment of malignant tumors. However, low intratumoral hydrogen peroxide level and complex biological barriers hinder the ability of nanomedicines to generate sufficient reactive oxygen species (ROS) and achieve tumor penetration. Here a near‐infrared (NIR)‐driven ROS self‐supplying nanomotor is successfully designed for synergistic tumor chemodynamic therapy (CDT) and photothermal therapy (PTT). Janus nanomotor is created by the asymmetrical modification of polydopamine (PDA) with zinc peroxide (ZnO2) and subsequent ferrous ion (Fe2+) chelation via the polyphenol groups from the PDA, here refer as ZnO2@PDA‐Fe (Z@P‐F). ZnO2 is capable of slowly releasing hydrogen peroxide (H2O2) into an acidic tumor microenvironment (TME) providing sufficient ingredients for the Fenton reaction necessary for ferroptosis. Upon NIR laser irradiation, the loaded Fe2+ is released and a thermal gradient is simultaneously formed owing to the asymmetric PDA coating, thus endowing the nanomotor with self‐thermophoresis based enhanced diffusion for subsequent lysosomal escape and tumor penetration. Therefore, the release of ferrous ions (Fe2+), self‐supplied H2O2, and self‐thermophoresis of nanomotors with NIR actuation further improve the synergistic CDT/PTT efficacy, showing great potential for active tumor therapy.
Easy Direct Functionalization of 2D MoS2 Applied in Covalent Hybrids with PANI as Dual Blend Supercapacitive Materials
Authors: Crisci Matteo , Boll Felix , Domenici Sara , Gallego Jaime , Smarsly Bernd , Wang Mengjiao , Lamberti Francesco , Rubino Andrea , Gatti Teresa 
Published: October 2024

AbstractThe pressing demand for more sustainable energy provision and the ongoing transition toward renewable resources underline the critical need for effective energy storage solutions. To address this challenge, scientists persistently explore new compounds and hybrids and, in such a dynamic research field, 2D materials, particularly transition metal di‐chalcogenides (TMDCs), show great potential for electrochemical energy storage uses. Simultaneously, also conductive polymers (CPs) are interesting and versatile supercapacitor materials, especially polyaniline (PANI), which is extensively studied for this purpose. In this work, a powerful method to combine TMDCs and PANI into covalently grafted hybrids starting from aniline functionalized few‐layers 1T‐MoS2, attained by a facile direct arylation with iodoaniline, is presented. The hybrids provide circa 70 F g−1 specific capacitance in a pseudo device setup, coupled with a robust capacitance retention of well over 80% for up to 5000 cycles. These findings demonstrate the potential of similar covalent composites to work as active components for novel, innovative energy storage technologies. At the same time, the successful synthesis marks the efficacy of direct covalent grafting of conductive polymer on the surface of 2D TMDCs for stable functional materials.
Chemical Sensor Technologies for Sustainable Development: Recent Advances, Classification, and Environmental Monitoring
Authors: Inobeme Abel , Natarajan Arunadevi , Pradhan Safalmani , Adetunji Charles Oluwaseun , Ajai Alexander Ikechukwu , Inobeme Jonathan , Tsado Mathew John , Jacob John Olusanya , Pandey Shyam S. , Singh Kshitij RB , Singh Jay 
Published: October 2024

AbstractOne of the significant issues of concern in recent times is detecting, quantifying, and monitoring various chemical contaminants in the environment. Numerous inorganic and organic substances are discharged into the environment from various anthropogenic activities, thereby polluting the ecosystems' air, water, soil, and other components. These contaminants have been documented to have deleterious effects on humans, animals, and the environment. Therefore, the need for monitoring and continual quantification of the contents of these contaminants in various environmental matrices becomes paramount. Many diverse sensors are fabricated for multiple utilizations, including liquids and gas sensors, wireless sensors, electronic tongues, and noses for detecting volatile airborne substances, pollutants, and effluents. This review focuses on cutting‐edge technology used in chemical sensors for environmental protection and sustainable development. It also discusses the fabrication and development of chemical sensors and their working principles. In addition, highlights about the applications of chemical sensors in environmental monitoring are also elaborated. This review article discusses emerging sensor technologies and their application in ecological monitoring. Further, the recognition of chemical warfare agents and homeland security applications with the help of bioelectronic nose and tongue is discussed. Finally, some challenges associated with chemical sensors and future trends are also attempted.
Linear and Nonlinear Optical Properties of Symmetric and Asymmetric Double Triangular Quantum Dots Withinside the Presence of Magnetic Field
Authors: AL Emre Bahadir , Ali Norshamsuri , Endut Rosdisham , Aljunid Syed Alwee , Ali Norshah Rizal , Yusof Nor Roshidah 
Published: October 2024

AbstractLinear and third‐order nonlinear optical absorption coefficients and relative refractive index changes in symmetric and asymmetric double triangular quantum dots are examined theoretically. The dependence of these optical properties on the magnetic field is examined. After calculating energies and wave functions within the effective mass and parabolic band approaches, analytical expressions of linear and nonlinear optical properties are obtained using the compact density matrix approach and iterative method. Numerical calculations are presented for typical GaAs/AlGaAs material. The results show that the magnetic field causes different effects on the and transitions. Moreover, the calculated results also reveal that the resonance frequency and nonlinear contribution are different in symmetric and asymmetric structures. As a result, it is concluded that the magnetic field plays a vital and important role in the electronic and optical properties of the system and can be used to tune the inter‐subband transitions and change the corresponding optical sensitivities.
The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization
Authors: Li Bin , Xia Cong , He Wanyu , Liu Jingyi , Duan Ruoyu , Ji Zhihua , Pan Xiaoyue , Zhou Yanlin , Yu Guoying , Wang Lan 
Published: October 2024

AbstractAcute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening condition with a high mortality rate of ≈40%. Thyroid hormones (THs) play crucial roles in maintaining homeostasis of the cellular microenvironment under stress. The previous studies confirmed that the clinical‐stage TH analog GC‐1 significantly alleviates pulmonary fibrosis by improving the function of mitochondria in epithelial cells. However, the effects of GC‐1 on macrophages in lung injury and the related mechanisms remain unclear. This study evaluated the therapeutic effects of GC‐1 in two murine models of lipopolysaccharide (LPS)‐ or hydrochloric acid (HCl)‐induced ALI. Additionally, mouse alveolar macrophages (AMs) and human THP‐1‐derived macrophages are utilized to investigate the impact of GC‐1 on macrophage polarization. GC‐1 effectively reduces the inflammatory response and lung injury in ALI mice, as evidenced by neutrophil infiltration, cytokine levels, alveolar fluid clearance, and pulmonary pathology. Notably, GC‐1 selectively inhibits M1 macrophage polarization, which may be achieved by impeding NF‐κB signaling activation through the DNMT3b‐PPARγ‐NF‐κB pathway in a TH receptor β1 (TRβ1)‐dependent manner, consequently suppressing the polarization of macrophages toward the M1 phenotype and overproduction of inflammatory cytokines. Overall, these findings highlight the immunomodulatory property of GC‐1 as an anti‐inflammatory strategy for ALI/ARDS and inflammation‐related diseases.
Broad‐Spectrum Engineered Multivalent Nanobodies Against SARS‐CoV‐1/2
Authors: Wang Zhihong , Shi Zhuangzhuang , Liao Xiaochen , Quan Guiqi , Dong Hui , Zhao Pinnan , Zhou Yangyihua , Shi Ning , Wang Jie , Wu Yahui , Qiao Chunxia , Li Xin ying , Zhang Ran , Wang Zekun , Wang Tiecheng , Gao Xiang , Feng Jiannan , Luo Longlong 
Published: October 2024

AbstractSARS‐CoV‐2 Omicron sublineages escape most preclinical/clinical neutralizing antibodies in development, suggesting that previously employed antibody screening strategies are not well suited to counteract the rapid mutation of SARS‐CoV‐2. Therefore, there is an urgent need to screen better broad‐spectrum neutralizing antibody. In this study, a comprehensive approach to design broad‐spectrum inhibitors against both SARS‐CoV‐1 and SARS‐CoV‐2 by leveraging the structural diversity of nanobodies is proposed. This includes the de novo design of a fully human nanobody library and the camel immunization‐based nanobody library, both targeting conserved epitopes, as well as the development of multivalent nanobodies that bind nonoverlapping epitopes. The results show that trivale B11‐E8‐F3, three nanobodies joined tandemly in trivalent form, have the broadest spectrum and efficient neutralization activity, which spans from SARS‐CoV‐1 to SARS‐CoV‐2 variants. It is also demonstrated that B11‐E8‐F3 has a very prominent preventive and some therapeutic effect in animal models of three authentic viruses. Therefore, B11‐E8‐F3 has an outstanding advantage in preventing SARS‐CoV‐1/SARS‐CoV‐2 infections, especially in immunocompromised populations or elderly people with high‐risk comorbidities.
Siglec‐G Suppresses CD8+ T Cells Responses through Metabolic Rewiring and Can be Targeted to Enhance Tumor Immunotherapy
Authors: Yin Shenhui , Li Chunzhen , Shen Xin , Yu Guanyu , Cui Likun , Wu Yunyang , He Yixian , Yu Shu , Chen Jie , Lu Shaoteng , Qiu Guifang , Song Mengqi , Qian Cheng , Zou Zui , Yu Yizhi , Xu Sheng 
Published: October 2024

AbstractCD8+ T cells play a critical role in cancer immune‐surveillance and pathogen elimination. However, their effector function can be severely impaired by inhibitory receptors such as programmed death‐1 (PD‐1) and T cell immunoglobulin domain and mucin domain‐3 (Tim‐3). Here Siglec‐G is identified as a coinhibitory receptor that limits CD8+ T cell function. Siglec‐G is highly expressed on tumor‐infiltrating T cells and is enriched in the exhausted T cell subset. Ablation of Siglec‐G enhances the efficacy of adoptively transferred T cells and chimeric antigen receptor (CAR) T cells in suppressing solid tumors growth. Mechanistically, sialoglycan ligands, such as CD24 on tumor cells, activate the Siglec‐G‐SHP2 axis in CD8+ T cells, impairing metabolic reprogramming from oxidative phosphorylation to glycolysis, which dampens cytotoxic T lymphocyte (CTL) activation, expansion, and cytotoxicity. These findings discover a critical role for Siglec‐G in inhibiting CD8+ T cell responses, suggesting its potential therapeutic effect in adoptive T cell therapy and tumor immunotherapy.
Multidirectional Filamented Light Biofabrication Creates Aligned and Contractile Cardiac Tissues
Authors: Jones Lewis S. , Filippi Miriam , Michelis Mike Yan , Balciunaite Aiste , Yasa Oncay , Aviel Gal , Narciso Maria , Freedrich Susanne , Generali Melanie , Tzahor Eldad , Katzschmann Robert K. 
Published: October 2024

AbstractBiofabricating 3D cardiac tissues that mimic the native myocardial tissue is a pivotal challenge in tissue engineering. In this study, we fabricate 3D cardiac tissues with controlled, multidirectional cellular alignment and directed or twisting contractility. We show that multidirectional filamented light can be used to biofabricate high‐density (up to 60 × 106 cells mL−1) tissues, with directed uniaxial contractility (3.8x) and improved cell‐to‐cell connectivity (1.6x gap junction expression). Furthermore, by using multidirectional light projection, we can partially overcome cell‐induced light attenuation, and fabricate larger tissues with multidirectional cellular alignment. For example, we fabricate a tri‐layered myocardium‐like tissue and a bi‐layered tissue with torsional contractility. The approach provides a new strategy to rapidly fabricate aligned cardiac tissues relevant to regenerative medicine and biohybrid robotics.
Space‐Confined Amplification for In Situ Imaging of Single Nucleic Acid and Single Pathogen on Biological Samples
Authors: Yang Tao , Li Dong , Luo Zisheng , Wang Jingjing , Xiao Fangbin , Xu Yanqun , Lin Xingyu 
Published: October 2024

AbstractDirect in situ imaging of nucleic acids on biological samples is advantageous for rapid analysis without DNA extraction. However, traditional nucleic acid amplification in aqueous solutions tends to lose spatial information because of the high mobility of molecules. Similar to a cellular matrix, hydrogels with biomimetic 3D nanoconfined spaces can limit the free diffusion of nucleic acids, thereby allowing for ultrafast in situ enzymatic reactions. In this study, hydrogel‐based in situ space‐confined interfacial amplification (iSCIA) is developed for direct imaging of single nucleic acid and single pathogen on biological samples without formaldehyde fixation. With a polyethylene glycol hydrogel coating, nucleic acids on the sample are nanoconfined with restricted movement, while in situ amplification can be successfully performed. As a result, the nucleic acids are lighted‐up on the large‐scale surface in 20 min, with a detection limit as low as 1 copy/10 cm2. Multiplex imaging with a deep learning model is also established to automatically analyze multiple targets. Furthermore, the iSCIA imaging of pathogens on plant leaves and food is successfully used to monitor plant health and food safety. The proposed technique, a rapid and flexible system for in situ imaging, has great potential for food, environmental, and clinical applications.
Ultra‐Stable Aqueous Zinc Anodes: Enabling High‐Performance Zinc‐Ion Batteries via a ZnSiF6‐Derived Protective Interphase
Authors: Huang Yongfeng , Guo Rongsheng , Li Zejian , Zhang Jiajia , Liu Wenbao , Kang Feiyu 
Published: October 2024

AbstractZinc‐ion batteries (ZIBs) hold immense promise as next‐generation energy storage solutions, however, the practical application of zinc anodes is hindered by dendrite formation and parasitic side reactions. Engineering a stable solid‐ eletrolyte interphase (SEI) is crucial for addressing these issues. This study proposes a novel strategy to enhance Zn anode performance by incorporating a ZnSiF6 additive into a standard ZnSO4 (ZSO) electrolyte. The ZnSiF6 additive facilitates the formation of a stable, fluorine‐rich SEI on the Zn anode surface. Characterization reveals a hierarchical SEI structure, primarily composed of porous alkali zinc sulfate (ZHS) with embedded ZnF2. This unique architecture promotes rapid zinc ion desolvation and efficient transport, enhances corrosion resistance, and mitigates hydrogen evolution. Consequently, ZnSiF6‐modified cells exhibit exceptional cycling stability, exceeding 3000 hours at 0.5 mA cm−2 and 560 hours at 10 mA cm−2, significantly outperforming ZSO‐based cells. The modified cells also achieve high areal capacities (10 mAh cm−2), indicating superior zinc utilization. This work provides key insights for designing stable electrode/electrolyte interfaces, contributing to the development of high‐performance aqueous ZIBs.
Biomimetic Scaffolds Regulating the Iron Homeostasis for Remolding Infected Osteogenic Microenvironment
Authors: Yin Mengting , Liu Zhiqing , Sun Zhongyi , Qu Xinyu , Chen Ziyan , Diao Yuying , Cheng Yuxuan , Shen Sisi , Wang Xiansong , Cai Zhuyun , Lu Bingqiang , Tan Shuo , Wang Yan , Zhao Xinyu , Chen Feng 
Published: October 2024

AbstractThe treatment of infected bone defects (IBDs) needs simultaneous elimination of infection and acceleration of bone regeneration. One mechanism that hinders the regeneration of IBDs is the iron competition between pathogens and host cells, leading to an iron deficient microenvironment that impairs the innate immune responses. In this work, an in situ modification strategy is proposed for printing iron‐active multifunctional scaffolds with iron homeostasis regulation ability for treating IBDs. As a proof‐of‐concept, ultralong hydroxyapatite (HA) nanowires are modified through in situ growth of a layer of iron gallate (FeGA) followed by incorporation in the poly(lactic‐co‐glycolic acid) (PLGA) matrix to print biomimetic PLGA based composite scaffolds containing FeGA modified HA nanowires (FeGA‐HA@PLGA). The photothermal effect of FeGA endows the scaffolds with excellent antibacterial activity. The released iron ions from the FeGA‐HA@PLGA help restore the iron homeostasis microenvironment, thereby promoting anti‐inflammatory, angiogenesis and osteogenic differentiation. The transcriptomic analysis shows that FeGA‐HA@PLGA scaffolds exert anti‐inflammatory and pro‐osteogenic differentiation by activating NF‐κB, MAPK and PI3K‐AKT signaling pathways. Animal experiments confirm the excellent bone repair performance of FeGA‐HA@PLGA scaffolds for IBDs, suggesting the promising prospect of iron homeostasis regulation therapy in future clinical applications.