bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potentially avoidable and ambulatory care sensitive hospitalisations among forced migrants: a protocol for a systematic review and meta-analysis
Authors: Lichtl Célina , Gewalt Sandra Claudia , Noest Stefan , Szecsenyi Joachim , Bozorgmehr Kayvan 
Published: September 2016

IntroductionThere is an increasing number of forced migrants globally, including refugees, asylum seekers, internally displaced persons and undocumented migrants. According to international law, forced migrants should enjoy access to health services free of discrimination equivalent to the host population, but they face barriers to healthcare worldwide. This may lead to a delay in care and result in preventable hospital treatment, referred to as potentially preventable hospitalisation (PPH) or ambulatory care sensitive hospitalisation (ACSH). There is as yet no overview of the prevalence of PPH in different countries and groups of forced migrants, and it is unknown whether the concept has been used among these migrant groups. We aim to systematically review the evidence (1) on the prevalence of PPH among forced migrants and (2) on differences in the prevalence of PPH between forced migrants and the general host population.Methods and analysisA systematic review will be conducted searching databases (PubMed/MEDLINE, Web of Science/Knowledge, Cochrane Library, CINAHL, Google Scholar) and the internet (Google). Inclusion criteria: observational studies on forced migrants reporting PPH or ACSH with or without comparison groups published in the English or German language. Exclusion criteria: studies on general migrant groups or hospitalisations without clear reference to avoidability. Study selection: titles, abstracts and full texts will be screened in duplicate for eligibility. Data on the prevalence of PPH/ACSH among forced migrants, as well as any reported prevalence differences between host populations, will be systematically extracted. Quality appraisal will be performed using standardised checklists. The evidence will be synthesised in tabular form and by means of forest plots. A meta-analysis will be performed only among homogeneous studies (in terms of design and population).Ethics and disseminationEthical clearance is not necessary (secondary research). The results will be disseminated via publication in open access journals, conferences and public media.PROSPERO registration numberCRD42016037081.
Prevalence and patterns of tobacco smoking among Chinese adult men and women: findings of the 2010 national smoking survey
Authors: Liu Shiwei , Zhang Mei , Yang Ling , Li Yichong , Wang Limin , Huang Zhengjing , Wang Linhong , Chen Zhengming , Zhou Maigeng 
Published: September 2016

BackgroundChina consumes about 40% of the world's cigarettes, predominantly by men, following a large increase in recent decades. We assess sex-specific prevalence and changing patterns of smoking in Chinese adults in the current decade.MethodsA nationally representative survey of smoking was conducted in 2010 among 100 000 Chinese adults aged ≥18 years, using a multistage stratified cluster sampling method. Information on smoking frequency, type, amount, age started and quitting was collected. Sex-specific standardised prevalence and means were analysed and compared with estimates in the 1996 national survey.ResultsIn Chinese men aged ≥18, 62.4% were ever-smokers in 2010, including 54.0% current smokers and 8.4% ex-smokers. The smoking prevalence was higher in rural than in urban men (63.9% vs 58.4%). In younger men, the age to start smoking was earlier and exclusive cigarette use was much higher. Among current smokers, only 17.3% intended to quit. Compared with a similar survey in 1996 among adults aged 30–69, more smokers had quit in 2010 than in 1996 (11.0% vs 4.2%), but the number of cigarettes smoked per current smoker was higher (17.9 vs 15.2). In Chinese women, only 3.4% ever smoked and there has been a large intergenerational decrease in smoking uptake rates. In 2010, there were 318 million current smokers in China, consuming an estimated 1740 billion cigarettes.ConclusionsThe prevalence of smoking remained extremely high in men, but low and falling in Chinese women. Tobacco smoking remains an important public health issue in China, and stronger and more efficient tobacco control is urgently needed.
The effectiveness of tobacco control policies on vulnerable populations in the USA: a review
Authors: Vijayaraghavan Maya , Schroeder Steven A , Kushel Margot 
Published: September 2016

AbstractDespite population-wide efforts to reduce tobacco use, low-income populations in the USA have much higher rates of tobacco use compared with the general population. The principal components of tobacco control policies in the USA include cigarette taxes, clean indoor air laws and comprehensive interventions to increase access to tobacco cessation services. In this review, we describe the effectiveness of these policies and interventions in reducing tobacco use among vulnerable populations, focusing on persons with mental health disorders and substance use disorders, persons who have experienced incarceration or homelessness, and low-income tenants of public housing. We discuss the challenges that evolving tobacco and nicotine products pose to tobacco control efforts. We conclude by highlighting the clinical implications of treating tobacco dependence in healthcare settings that serve vulnerable populations.
Geochemical characterization and petrogenesis of mafic granulites from the Central Indian Tectonic Zone (CITZ)
Authors: Alam Meraj , Choudhary A. K. , Mouri Hassina , Ahmad Talat 
Published: September 2016

Abstract

A mafic magmatic sequence of the Bhandara–Balaghat Granulite (BBG) Belt is represented by gabbroic rocks containing orthopyroxene (Opx)–clinopyroxene (Cpx)–plagioclase (Pl)–hornblende±quartz±garnet and showing tholeiitic affinity. These rocks are divided into two groups: (I) garnet-bearing; and (II) garnet-free. The garnet-bearing group is characterized by nearly flat REE patterns. In the multi-element plots, Sr, Zr and Ti show negative anomalies, indicating plagioclase, Ti-magnetite and apatite fractionation. The garnet-free rocks are geochemically subdivided into two subgroups: IIa and IIb. Subgroup IIa is marked by flat REE patterns; the LREE shows 20–30 times chondrite abundances and small positive Eu anomalies. Multi-element patterns show negative anomalies of Nb, P and Ti. Subgroup IIb is characterized by slightly enriched patterns; the LREE shows 10–60 times chondrite abundances. The REE patterns for the Subgroup IIb show moderately to highly fractionated LREE with flat HREE. Multi-element plots show negative anomalies in Nb, Ti and Zr. The Nd–Ce relationship suggests that mafic granulites of the BBGs are derived from higher degrees (Group I,
c.
15–30%; Subgroup IIa,
c.
20–40%; and Subgroup IIb,
c.
18–35%) of partial melting of variably enriched mantle sources, followed by the evolution of the parental melt by fractional crystallization of Opx–Cpx–Pl. The geochemical signatures also suggest that the magma was further modified by crustal contamination during the course of its evolution. The Nd (
T
DM
) model ages, which vary from 3.2 to 1.6 Ga, suggest a long-term evolution of the mafic granulites, possibly starting with overprinting of the isotope composition of their mantle source by crustal isotope signatures as a consequence of crustal recycling; evolving by emplacement and crystallization of the protolith at 2.7 Ga, as well as through later tectonotermal events up to granulite-facies metamorphism and exhumation of the BBG Belt during the collision of the Archaean Bundelkhand and Bastar cratons, and the formation of the Central Indian Tectonic Zone (CITZ) at 1.5 Ga.
Grape Seed Procyanidin Extract Mediates Antineoplastic Effects against Lung Cancer via Modulations of Prostacyclin and 15-HETE Eicosanoid Pathways
Authors: Mao Jenny T. , Smoake Jane , Park Heesung K. , Lu Qing-Yi , Xue Bingye 
Published: September 2016

Abstract
Grape seed procyanidin extract (GSE) has been reported to exert antineoplastic properties via the inhibition of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) eicosanoid pathways. In addition, ample data link carcinogenesis to inflammatory events involving other major eicosanoid metabolic pathways, including prostacyclin (PGI2) and 15-hydroxyeicosatetraenoic acid (15-HETE). We therefore evaluated the effects of GSE on prostacyclin synthase (PTGIS)/PGI2 and 15-lipoxigenase-2 (15-LOX-2)/15-HETE productions by human lung premalignant and malignant cells and correlated the findings with antiproliferative or proapoptotic effects of GSE. The effects of GSE on PGI2 and 15-HETE productions by human bronchoalveolar lavage (BAL) cells ex vivo were also determined. We further evaluated the bioactivity of oral administration of leucoselect phytosome (a standardized GSE) in the lungs of subjects participating in a lung cancer chemoprevention trial, by comparing the antiproliferative effects of coculturing matched pre- versus posttreatment BAL fluids with lung premalignant and malignant cells. GSE significantly increased PGI2 (as measured by 6-keto PGF1α) and 15-HETE productions by these cells. Transfections of PTGIS or 15-LOX-2–specific siRNA partially abrogated the antiproliferative or proapoptotic effects of GSE in lung premalignant and malignant cells, respectively. GSE also increased PTGIS and inhibition of caspase-3, and transfection of 15-LOX-2 siRNA abrogated the GSE-induced apoptosis in A549 cells. In addition, culture supernatants from ex vivo GSE-treated baseline BAL cells, as well as BAL fluids from subjects treated with leucoselect phytosome, significantly decreased proliferations of lung premalignant and malignant cells. Our findings support the continued investigation of GSE as an anti-neoplastic and chemopreventive agent against lung cancer. Cancer Prev Res; 9(12); 925–32. ©2016 AACR.
Prevalence of Elevated Lp(a) Mass Levels and Patient Thresholds in 532 359 Patients in the United States
Authors: Varvel Steve , McConnell Joseph P. , Tsimikas Sotirios 
Published: September 2016

Objective—
Elevated lipoprotein(a) [Lp(a)] is a causal, independent risk factor for cardiovascular disease and aortic stenosis. We aimed to define the prevalence and patient thresholds of elevated Lp(a) levels in the United States.

Approach and Results—

We analyzed Lp(a) levels in 532 359 subjects from 2 data sets: (1) in 531 144 subjects from a referral laboratory and (2) in 915 patients from a tertiary referral center. Lp(a) mass levels were measured by immunoturbidometric assays in both centers and expressed as mg/dL. At the referral laboratory, the median age (interquartile range) of the subjects was 57.0 (46–67) years, and 51.9% were female. Lp(a) levels were skewed rightward as expected. The mean±SD levels were 34.0±40.0 mg/dL, and median (interquartile range) levels were 17 (7–47) mg/dL, with range 0 to 907 mg/dL. Lp(a) levels at 75%, 80%, 90%, 95%, 99%, and 99.9% percentiles were >47, >60, >90, >116, >180, and >245 mg/dL, respectively. At the referral laboratory, Lp(a) levels >30 and >50 mg/dL were present in 35.0% and 24.0% of subjects, respectively, and at the tertiary referral center, 39.5% and 29.2%, respectively. Females had higher mean (SD) (37.0 [42.7] versus 30.7 [36.7];
P
<0.0001) and median (interquartile range) (19 [8–53] versus 15 [7–42];
P
<0.0001) Lp(a) than males.

Conclusions—
This is the largest database to assess the distribution of Lp(a) and is derived from patients as opposed to general populations. Lp(a) levels >30 and >50 mg/dL were fairly common, particularly in a tertiary care setting. These data may inform consensus documents, guidelines, and therapeutic cutoffs for Lp(a)-mediated cardiovascular risk.
Aortic Elastic Properties in Preschool Children Born Preterm
Authors: Odri Komazec Irena , Posod Anna , Schwienbacher Martin , Resch Maria , Pupp Peglow Ulrike , Kiechl Stefan , Baumgartner Daniela , Kiechl-Kohlendorfer Ursula 
Published: September 2016

Objective—
Preterm birth predisposes children to the development of cardiovascular diseases in adulthood. The aim of this study was to characterize elastic properties of the aorta at preschool age and test the hypothesis that prematurity is associated with decreased aortic distensibility and increased stiffness, both of which are predictors of increased cardiovascular risk.

Approach and Results—

In an observational study of 76 five- to seven-year-old children born at a gestational age <32 weeks and 79 term-born controls, elastic parameters of the ascending and descending abdominal aorta were determined noninvasively by means of M mode echocardiographic tracings and calculated using computerized wall contour analysis. Compared with children born at term, the preterm group showed significantly reduced distensibility and increased stiffness of the descending abdominal aorta. These results remained significant under multivariable adjustment for birth weight z score, maternal smoking in pregnancy, maternal education, family history of cardiovascular disease, breastfeeding, childhood nutrition, and current body mass index z score (multivariable odds ratios and 95% confidence intervals 5.1, 1.7–15.9;
P
=0.005 and 2.8, 1.0–7.9;
P
=0.046, respectively). Further adjustment for intravenous lipid therapy attenuated the strength of association. Elastic properties of the ascending aorta did not differ between the 2 study groups.

Conclusions—
Children born preterm are characterized by decreased elastic properties of the descending abdominal aorta potentially attributable to impaired viscoelastic properties of and lipid damage to the aorta. Clinical follow-up of preterm infants with a focus on aortic elastic properties may be useful for tailoring early prevention programs and counteracting cardiovascular risk in adulthood.
Fluid-Attenuated Inversion Recovery Vascular Hyperintensity Topography, Novel Imaging Marker for Revascularization in Middle Cerebral Artery Occlusion
Authors: Liu Dezhi , Scalzo Fabien , Rao Neal M. , Hinman Jason D. , Kim Doojin , Ali Latisha K. , Saver Jeffrey L. , Sun Wen , Dai Qiliang , Liu Xinfeng , Liebeskind David S. 
Published: September 2016

Background and Purpose—
In acute arterial occlusion, fluid-attenuated inversion recovery vascular hyperintensity (FVH) has been linked to slow flow in leptomeningeal collaterals and cerebral hypoperfusion, but the impact on clinical outcome is still controversial. In this study, we aimed to investigate the association between FVH topography or FVH-Alberta Stroke Program Early CT Score (ASPECTS) pattern and outcome in acute M1-middle cerebral artery occlusion patients with endovascular treatment.

Methods—
We included acute M1-middle cerebral artery occlusion patients treated with endovascular therapy (ET). All patients had diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery before ET. Distal FVH-ASPECTS was evaluated according to distal middle cerebral artery-ASPECT area (M1–M6) and acute DWI lesion was also reviewed. The presence of FVH inside and outside DWI-positive lesions was separately analyzed. Clinical outcome after ET was analyzed with respect to different distal FVH-ASPECTS topography.

Results—

Among 101 patients who met inclusion criteria for the study, mean age was 66.2±17.8 years and median National Institutes of Health Stroke Scale was 17.0 (interquartile range, 12.0–21.0). FVH-ASPECTS measured outside of the DWI lesion was significantly higher in patients with good outcome (modified Rankin Scale [mRS] score of 0–2; 8.0 versus 4.0,
P
<0.001). Logistic regression demonstrated that FVH-ASPECTS outside of the DWI lesion was independently associated with clinical outcome of these patients (odds ratio, 1.3; 95% confidence interval, 1.06–1.68;
P
=0.013). FVH-ASPECTS inside the DWI lesion was associated with hemorrhagic transformation (odds ratio, 1.3; 95% confidence interval, 1.04–1.51;
P
=0.019).

Conclusions—
Higher FVH-ASPECTS measured outside the DWI lesion is associated with good clinical outcomes in patients undergoing ET. FVH-ASPECTS measured inside the DWI lesion was predictive of hemorrhagic transformation. The FVH pattern, not number, can serve as an imaging selection marker for ET in acute middle cerebral artery occlusion.
Long-Term Clinical Impact of Vascular Brain Lesions on Magnetic Resonance Imaging in Older Adults in the Population
Authors: Kaffashian Sara , Soumaré Aïcha , Zhu Yi-Cheng , Mazoyer Bernard , Debette Stéphanie , Tzourio Christophe 
Published: September 2016

Background and Purpose—
White matter hyperintensity (WMH) volume and covert brain infarcts are highly prevalent in older adults and are often asymptomatic. We compared the impact of WMH volume and brain infarcts on risk of clinical stroke and dementia in older adults in the population.

Methods—
Participants were 1677 individuals aged ≥65 years from the 3-City Dijon study, who were free of stroke and dementia at baseline, followed-up for ≤12 years.

Results—
Both lesion types were comparably associated with an increased risk of stroke (adjusted hazard ratio, 1.72; 95% confidence interval, 1.24–2.40 for WMH volume and hazard ratio, 2.15; 95% confidence interval, 1.18–3.93 for brain infarcts), but only WMH volume was associated with an increased risk of dementia (hazard ratio, 1.41; 95% confidence interval, 1.09–1.83).

Conclusions—
The differential impact of WMH and brain infarcts on clinical stroke and dementia suggests relatively different prognostic value of the 2 lesions. WMHs may represent a particularly pertinent magnetic resonance imaging intermediate marker that can be utilized in optimizing prevention strategies for both stroke and dementia in primary care and in trials.
Demagogues and Demos in Athens
Authors: Rhodes P.J. 
Published: September 2016

M. I. Finley sought to rescue the ‘demagogue’ as an essential ingredient in Athens’ democratic processes. This paper explores the interactions of politicians and the assembly.
There is some evidence for pressure on men to attend and to vote on a particular side. There were many occasional speakers and proposers in addition to the few most active politicans. We should not think of a series of duels; and experienced assembly-goers were not mere ‘spectators of speeches’. Speakers could be supported by cheers or heckled. Nobody could count on the assembly’s voting as he wanted consistently time after time.
Politicians sought to cultivate an image, whether the aloof, magisterial image of Pericles or the extravagantly populist image of Cleon. Orators had to master a range of strategies to succeed, but there was not a simple division between élite politicians and a lower-class demos to whose tune they had to dance.
Extreme Rainfall from Landfalling Tropical Cyclones in the Eastern United States: Hurricane Irene (2011)
Authors: Liu Maofeng , Smith James A. 
Published: September 2016

Abstract
Hurricane Irene produced catastrophic rainfall and flooding in portions of the eastern United States from 27 to 29 August 2011. Like a number of tropical cyclones that have produced extreme flooding in the northeastern United States, Hurricane Irene was undergoing extratropical transition during the period of most intense rainfall. In this study the rainfall distribution of landfalling tropical cyclones is examined, principally through analyses of radar rainfall fields and high-resolution simulations using the Weather Research and Forecasting (WRF) Model. In addition to extratropical transition, the changing storm environment at landfall and orographic precipitation mechanisms can be important players in controlling the distribution of extreme rainfall. Rainfall distribution from landfalling tropical cyclones is examined from a Lagrangian perspective, focusing on times of landfall and extratropical transition, as well as interactions of the storm circulation with mountainous terrain. WRF simulations capture important features of rainfall distribution, including the pronounced change in rainfall distribution during extratropical transition. Synoptic-scale analyses show that a deep baroclinic zone developed and strengthened in the left-front quadrant of Irene, controlling rainfall distribution over the regions experiencing most severe flooding. Numerical experiments were performed with WRF to examine the role of mountainous terrain in altering rainfall distribution. Analyses of Hurricane Irene are placed in a larger context through analyses of Hurricane Hannah (2008) and Hurricane Sandy (2012).
The Development and Evaluation of a Statistical–Dynamical Tropical Cyclone Genesis Guidance Tool
Authors: Halperin Daniel J. , Hart Robert E. , Fuelberg Henry E. , Cossuth Joshua H. 
Published: September 2016

Abstract
The National Hurricane Center (NHC) has stated that guidance on tropical cyclone (TC) genesis is an operational forecast improvement need, particularly since numerical weather prediction models produce TC-like features and operationally required forecast lead times recently have increased. Using previously defined criteria for TC genesis in global models, this study bias corrects TC genesis forecasts from global models using multiple logistic regression. The derived regression equations provide 48- and 120-h probabilistic genesis forecasts for each TC genesis event that occurs in the Environment Canada Global Environmental Multiscale Model (CMC), the NCEP Global Forecast System (GFS), and the Met Office's global model (UKMET). Results show select global model output variables are good discriminators between successful and unsuccessful TC genesis forecasts. Independent verification of the regression-based probabilistic genesis forecasts during 2014 and 2015 are presented. Brier scores and reliability diagrams indicate that the forecasts generally are well calibrated and can be used as guidance for NHC’s Tropical Weather Outlook product. The regression-based TC genesis forecasts are available in real time online.
Effects of Rainfall on Vehicle Crashes in Six U.S. States
Authors: Black Alan W. , Villarini Gabriele , Mote Thomas L. 
Published: September 2016

Abstract
Rainfall is one of many types of weather hazard that can lead to motor vehicle crashes. To better understand the link between rainfall and crash rates, daily gridded precipitation data and automobile crash data are gathered for six U.S. states (Arkansas, Georgia, Illinois, Maryland, Minnesota, Ohio) for the period 1996–2010. A matched pair analysis is used to pair rainfall days with dry days to determine the relative risk of crash, injury, and fatality. Overall, there is a statistically significant increase in crash and injury rates during rainfall days of 10% and 8%, respectively, leading to an additional 28 000 crashes and 12 000 injuries in the 1 May–30 September period each year relative to what would be expected if those days were dry. The risk of crashes and injuries increases for increasing daily rainfall totals, with an overall increase in crashes and injuries of 51% and 38% during days with more than 50 mm (2 in.) of rainfall. While urban counties and rural counties with and without interstates each saw increased crash risk during rainfall, urban counties saw the most significant increases in relative risk. There are a number of exceptions to these broad spatial patterns, indicating that relative risk varies in ways that are not explained solely by meteorological factors.