bluuebunny/crossref_metadata_2025_split huggingface dataset:
Draft genomes of 10
Vibrio cholerae
isolates collected in Sudan in 2019
Authors: Adam Muatsim Ahmed Mohammed , Sims Sam , Awad Amina Ahmed , Meredith Luke , Mohamed Ahmed Basmat Abd Elhafeez , Ahmed Rayan Adel Abdelrahman , Saeed Hageer Alnazeer Ibrahim , Alkhidir Mohamed Abdalhafiz , Abdelgadir Muna Idris Ahmed , Mohamed Hanan Ali , Badi Lubna Ahmed , Vazquez Yaiza Gutierrez , Afrough Babak , Inamdar Leena , Kritz Angelika , Barakat Amal , Abualas Elamin , Bedri Shahinaz Ahmed 
Published: October 2024

ABSTRACT

This report presents the first genomes from positive cases of cholera in Sudan. Genomic analysis of 10
Vibrio cholerae
isolates, profiled as serogroup O1, reveals evidence of antimicrobial resistance genes and a 139-kb IncC plasmid with 99.74% identity to the multidrug-resistant plasmid pCNRVC190243 previously reported in Yemen and Lebanon.
Complete genome sequence of a high-risk
Escherichia coli
ST10 isolated from avian feces in Pakistan
Authors: Lee Jung Hun , Tareen Abdul Rauf , Kim Nam-Hoon , Jeong Chanyeong , Kang Byeonghyeon , Lee Gwangje , Kim Dae-Wi , Zahra Rabaab , Lee Sang Hee 
Published: October 2024

ABSTRACT

We present the complete genome sequence of
Escherichia coli
strain PEC1009 isolated from avian feces in Pakistan. The strain belongs to sequence type (ST) 10, a high-risk clone. The strain possesses two plasmids, and various plasmid-borne antibiotic resistance genes and chromosome-borne virulence factor genes were identified in its genome.
Introduction to Nonlocal Field Theory Including Gravity
Authors: Krasnikov N. V. 
Published: October 2024

Abstract
We give minireview of nonlocal field theory (infinite derivative field theory). We start with the discussion of the main peculiarities of nonlocal field theory on the example of $$d = 4$$ scalar $${{\phi }^{4}}$$-model. The nonlocal $${{\phi }^{4}}$$-model is ultraviolet finite, unitary, and macrocausal. One of the problems of nonlocal field theory is that the formfactor is an arbitrary entire function that makes the predictions extremely weak. We propose some additional principle that allows to fix the formfactor. Also we review the main results obtained in nonlocal quantum gravity, namely the nonlocal generalization of Einstein gravity leads to the superrenormalizable theory.
Enhanced Recovery After Surgery (ERAS) consensus recommendations for opioid-minimising pharmacological neonatal pain management
Authors: Pilkington Mercedes , Pentz Brandon , Short Kristin , Marchand Tyara , Aziz Saffa , Lam Jennifer Y , Spencer Adam , Brockel Megan A , Else Scott , McLuckie Duncan , Franklin Andrew , de Beer David , Raval Mehul V , Scott Michael , Brindle Mary E 
Published: October 2024

ObjectiveEnhanced recovery after surgery (ERAS) guidelines have been successfully applied to children and neonates. There is a need to provide evidence-based consensus recommendations to manage neonatal pain perioperatively to ensure adequate analgesia while minimising harmful side effects.MethodsFollowing a stakeholder needs assessment, an international guideline development committee (GDC) was established. A modified Delphi consensus iteratively defined the scope of patient and procedure inclusion, topic selection and recommendation content regarding the pharmacologic management of neonatal pain. Critical appraisal tools assessed the relevance and quality of full-text studies. Each recommendation underwent a formal Grades of Recommendation, Assessment, Development and Evaluation (GRADE) assessment of the quality of evidence and expert consensus was used to determine the strength of recommendations.ResultsThe GDC included paediatric anaesthesiologists, surgeons, and ERAS methodology experts. The population was defined as neonates at >32 weeks gestational age within 30 days of life undergoing surgery or painful procedures associated with surgery. Topic selection targeted pharmacologic opioid-minimising strategies. A total of 4249 abstracts were screened for non-opioid analgesia and 738 abstracts for the use of locoregional analgesia. Full-text review of 18 and 9 articles, respectively, resulted in two final recommendations with a moderate quality of evidence to use regular acetaminophen and to consider the use of locoregional analgesia. There was inadequate evidence to guide the use of other non-opioid adjuncts in this population.ConclusionsEvidence-based, ERAS-driven consensus recommendations were developed to minimise opioid usage in neonates. Further research is required in this population to optimize multimodal strategies for pain control.
Factors affecting implementation of a National Clinical Programme for self-harm in hospital emergency departments: a qualitative study
Authors: O'Connell Selena , Cully Grace , McHugh Sheena , Maxwell Margaret , Jeffers Anne , Kavalidou Katerina , Lovejoy Sally , Jennings Rhona , Russell Vincent , Arensman Ella , Griffin Eve 
Published: October 2024

BackgroundA substantial number of people experiencing self-harm or suicidal ideation present to hospital emergency departments (EDs). In 2014, a National Clinical Programme was introduced in EDs in Ireland to standardise care provision. Internationally, there has been limited research on the factors affecting the implementation of care for people who present with mental health crises in EDs.MethodsThis qualitative study examined factors influencing the implementation of the National Clinical Programme for Self-harm and Suicide-related Ideation in 15 hospitals in Ireland from early (2015–2017) through to later implementation (2019–2022). Semi-structured interviews were conducted with staff involved in programme delivery, with the topic guide and thematic analysis informed by the Consolidated Framework for Implementation Research.ResultsA total of 30 participants completed interviews: nurse specialists (n=16), consultant psychiatrists (n=6), nursing managers (n=2), emergency medicine staff (n=2) and members of the national programme team (n=4). Enablers of implementation included the introduction of national, standardised guidance for EDs; implementation strategies led by the national programme team; and training and support for nurse specialists. The following inner-setting factors were perceived as barriers to implementation in some hospitals: limited access to a designated assessment room, delayed access to clinical input and poor collaboration with ED staff. Overall, these barriers dissipated over time, owing to implementation strategies at national and local levels. The varied availability of aftercare impacted providers’ ability to deliver the programme and the adaptability of programme delivery had a mixed impact across hospitals.ConclusionsThe perceived value of the programme and national leadership helped to advance implementation. Strategies related to ongoing training and education, developing stakeholder interrelationships and evaluation and monitoring have helped address implementation barriers and promote continued sustainment of the programme. Continued efforts are needed to support nurse specialists delivering the programme and foster partnerships with community providers to improve the transition to aftercare.
National and regional trends in the prevalence of adolescent idiopathic scoliosis in South Korean military draftees
Authors: Kim Hong Jin , Kim J-H , Ha K-Y , Suk S-I , Chang D-G 
Published: October 2024

IntroductionRecent epidemiological and aetiological data on adolescent idiopathic scoliosis (AIS) among military draftees are scarce in nationwide and population-based databases. This retrospective, nationwide and population-based study aims to assess national and regional trends in the prevalence of AIS among military draftees in South Korea from 2013 to 2022.MethodsA total of 3 166 669 Korean males were screened at regional Military Manpower Administration (MMA) offices between 2013 and 2022. Based on routine chest radiographs, individuals with Cobb’s angle of ≥10° were screened and diagnosed with AIS using whole spine radiographs after excluding surgically treated AIS patients. Data from the MMA were retrospectively collected and the annual prevalence of the total and neglected AIS cases, along with 95% CIs, was assessed. Spearman correlation analysis was performed to evaluate the correlation between the prevalence of AIS and several aetiological factors.ResultsThe prevalence rate of AIS in the male adolescent population gradually increased from 2013 (0.44%, 95% CI 0.42% to 0.46%) to 2022 (1.33%, 95% CI 1.28% to 1.37%). The AIS rate increased overall in both capital/metropolitan areas and provinces but showed a fluctuating pattern in the capital/metropolitan area. The prevalence rate of neglected AIS showed a very slight increased trend during the same period (mean 0.05%, 95% CI 0.04% to 0.06%) and exhibited a similar pattern in both capital/metropolitan areas and provinces. Using correlation analysis with aetiological factors, the prevalence rate of AIS correlated with overweight or obesity rate (r=0.90, p<0.001) and growth hormone use (r=0.83, p<0.001).ConclusionsThe prevalence of AIS in the male population has increased, with a similar trend observed between capital/metropolitan areas and provinces in South Korea. Our correlation results support both the multifactorial cascade concepts for altered body composition effects and biomechanical progression based on the Hueter-Volkmann effect as the pathomechanisms of AIS.
Effectiveness of surfing on psychological health in military members: a systematic review
Authors: González-Devesa Daniel , Vilanova-Pereira María , Araújo-Solou B , Ayán-Pérez C 
Published: October 2024

IntroductionSurfing, a leisure activity known for its positive physical and mental health effects, has emerged as a potential therapeutic intervention. This study aims to systematically review the available evidence on the effects of surfing on mental health in active military personnel and veterans.MethodsStudies were searched across four electronic databases (MEDLINE/PubMed, Web of Science, SportDiscus and Scopus) until May 2024. The methodological quality of the included studies was assessed using the Physiotherapy Evidence Database, Methodological Index for Non-Randomized Studies and the Quality Assessment Tool for Before–After Studies with No Control Group scales.ResultsA total of seven studies met the inclusion criteria and were included. Depression and anxiety symptoms (n=7), positive affect (n=5) and pain (n=3) were the main outcomes analysed. Overall, the studies reviewed generally reported beneficial effects of surfing on depression, anxiety and positive affect. However, none of the four studies that examined pain as an outcome observed any positive effects of surfing.ConclusionThere is evidence indicating that surfing may positively influence the management of anxiety, depression and overall positive affect among military personnel. Nonetheless, it cannot be definitively concluded that surfing provides superior benefits compared with other forms of exercise.
Morris–Thorne-type wormholes with global monopole charge and the energy conditions
Authors: Goswami Jaydeep , Rahman Hafizur , Sikdar Rimi , Parvin Rina , Ahmed Faizuddin 
Published: October 2024

AbstractIn this paper, we investigate Morris–Thorne-type wormholes with global monopole charge using various shape function forms known in the literature. We solve the Einstein field equations incorporating an anisotropic energy–momentum tensor and obtain different physical quantities associated with the matter-content. A crucial aspect of this study is the non-exotic matter distribution, examined through the evaluation of energy conditions, and exploring how different shape functions impact these conditions. Additionally, the anisotropy parameter is calculated to quantify the extent of attractive or repulsive behavior. Our study demonstrates that for different types of shape function forms, the energy conditions are influenced by the global monopole parameter. Our findings provide valuable insights for further theoretical explorations of these fascinating hypothetical structures in the realm of general relativity and beyond.
Probing hidden leptonic scalar portals using the NA64 experiment at CERN
Authors: Ponten A. , Sieber H. , Oberhauser B. Banto , Crivelli P. , Kirpichnikov D. , Gninenko S. N. , Hösgen M. , Bueno L. Molina , Mongillo M. , Zhevlakov A. 
Published: October 2024

AbstractIn this study, we demonstrate the potential of the NA64 experiment at CERN SPS to search for New Physics processes involving $$e\rightarrow \mu $$

e
→
μ

transitions after the collision of 100 GeV electrons with target nuclei. A new Dark Sector leptonic portal in which a scalar boson $$\varphi $$
φ
could be produced in the lepton-flavor-changing bremsstrahlung-like reaction, $$eN\rightarrow \mu N\varphi $$

e
N
→
μ
N
φ

, is used as benchmark process. In this work, we develop a realistic Monte Carlo simulation of the NA64 experimental setup implementing the differential and total production cross-section computed at exact tree-level and applying the Weiszäcker–Williams phase space approximation. Using this framework, we investigate the main background sources and calculate the expected sensitivity of the experiment. The results indicate that with minor setup optimization, NA64 can probe a large fraction of the available parameter space compatible with the muon $$g-2$$

g
-
2

anomaly and the Dark Matter relic predictions in the context of a new Dark Sector leptonic portal with $$10^{11}$$

10
11

EOT. This result paves the way to the exploration of lepton-flavour-changing transitions in NA64.
COPING AND RESILIENCE IN ENTREPRENEURS
Authors: LUGO MARIA V. , HAMDAN HASAN 
Published: October 2024

The relationship between self-resilience, social resilience, coping and resilient coping is explored. A cross-sectional research design is employed. Survey respondents were recruited by panel owners in Centiment. A total of 381 entrepreneurs responded to the survey. Entrepreneurs self-identified themselves as members of each of the groups under study (White, African American and Hispanic). Results were stratified, analyzed and compared by ethnicity and gender. We found a statistically significant positive relationship between self-resilience and coping, and that coping mediates the relationship between self-resilience and resilient coping. The findings could help policymakers and community ecosystems to support the development of resiliency-related skills which could have important implications especially for those in disadvantaged circumstances.
COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type
Authors: Hilser James R. , Spencer Neal J. , Afshari Kimia , Gilliland Frank D. , Hu Howard , Deb Arjun , Lusis Aldons J. , Wilson Tang W.H. , Hartiala Jaana A. , Hazen Stanley L. , Allayee Hooman 
Published: October 2024

BACKGROUND:
COVID-19 is associated with acute risk of major adverse cardiac events (MACE), including myocardial infarction, stroke, and mortality (all-cause). However, the duration and underlying determinants of heightened risk of cardiovascular disease and MACE post–COVID-19 are not known.

METHODS:

Data from the UK Biobank was used to identify COVID-19 cases (n=10 005) who were positive for polymerase chain reaction (PCR
+
)-based tests for SARS-CoV-2 infection (n=8062) or received hospital-based
International Classification of Diseases version-10 (ICD-10
) codes for COVID-19 (n=1943) between February 1, 2020 and December 31, 2020. Population controls (n=217 730) and propensity score—matched controls (n=38 860) were also drawn from the UK Biobank during the same period. Proportional hazard models were used to evaluate COVID-19 for association with long-term (>1000 days) risk of MACE and as a coronary artery disease risk equivalent. Additional analyses examined whether COVID-19 interacted with genetic determinants to affect the risk of MACE and its components.

RESULTS:

The risk of MACE was elevated in COVID-19 cases at all levels of severity (HR, 2.09 [95% CI, 1.94–2.25];
P
<0.0005) and to a greater extent in cases hospitalized for COVID-19 (HR, 3.85 [95% CI, 3.51–4.24];
P
<0.0005). Hospitalization for COVID-19 represented a coronary artery disease risk equivalent since incident MACE risk among cases without history of cardiovascular disease was even higher than that observed in patients with cardiovascular disease without COVID-19 (HR, 1.21 [95% CI, 1.08–1.37];
P
<0.005). A significant genetic interaction was observed between the
ABO
locus and hospitalization for COVID-19 (
P
interaction
=0.01), with risk of thrombotic events being increased in subjects with non-O blood types (HR, 1.65 [95% CI, 1.29–2.09];
P
=4.8×10
−5
) to a greater extent than subjects with blood type O (HR, 0.96 [95% CI, 0.66–1.39];
P
=0.82).

CONCLUSIONS:
Hospitalization for COVID-19 represents a coronary artery disease risk equivalent, with post–acute myocardial infarction and stroke risk particularly heightened in non-O blood types. These results may have important clinical implications and represent, to our knowledge, one of the first examples of a gene-pathogen exposure interaction for thrombotic events.
Home-Time, Mortality, and Readmissions Among Patients Hospitalized With Heart Failure: A Baseline Prior to IMPLEMENT-HF
Authors: Tang Amber B. , Solomon Nicole , Chiswell Karen , Greene Stephen J. , Yancy Clyde W. , Jessup Mariell , Kittleson Michelle , Butler Javed , Sweitzer Nancy K. , Goldberg Lee R. , Lindenfeld Jo-Ann , Lewis Eldrin F. , Peterson Pamela N. , Paul Sara , Serdynski Lynn Mallas , Rutan Christine , Congdon Michelle , Cherkur Sruthi , Fonarow Gregg C. 
Published: October 2024

BACKGROUND:
Home-time is an emerging, patient-centered outcome that represents the amount of time a patient spends alive and outside of health care facility settings, comprising of hospitals, skilled nursing facilities, and acute rehabilitation centers. Studies evaluating home-time in the context of heart failure are limited, and the impact of quality improvement interventions on home-time has not been studied.

METHODS:
Medicare beneficiaries aged 65 years or older who were hospitalized for heart failure in the Get With the Guidelines-Heart Failure registry between 2019 and 2021 were included. Postdischarge home-time, mortality, and readmission rates at 30 days and 1 year were calculated with the goal of establishing baseline metrics before the initiation of IMPLEMENT-HF, a multicenter quality improvement program aimed at improving heart failure management.

RESULTS:

Overall, 66 019 patients were included across 437 sites. Median 30-day and 1-year home-time were 30 (18–30) and 333 (139–362) days, respectively. Only 22.1% of patients experienced 100% home-time in the year after discharge. Older patients spent significantly less time at home, with a median 1-year home-time of 302 (86–359) compared with 345 (211–365) days in patients over 85 and those between 65 and 74 years old, respectively (
P
<0.001). Black patients also experienced the least amount of home-time with only 328 (151–360) days at 1-year follow-up. Rates of heart failure readmission and all-cause mortality 1-year post-discharge were high at 29.8% and 37.0%, respectively.

CONCLUSIONS:
In this contemporary multicenter cohort, patients hospitalized with heart failure spent a median of 91.2% of their time in the year after discharge alive and at home, largely driven by high mortality rates. These findings serve as a preimplementation baseline for IMPLEMENT-HF, which will evaluate the impact of targeted heart failure initiatives on home-time and other clinical outcomes.
Abstract Mo047: DNA METHYLATION AND TRANSCRIPTIONAL MARKERS OF MYOCARDIAL REVERSE REMODELING IN HF PATIENTS ON LVAD SUPPORT
Authors: Shankar Thirupura S , Marchetti Marco , Srinivasan Harini , Lunde J Ty , Selzman Craig , Javier Hernandez Edgar , Tristani-Firouzi Martin , Drakos Stavros , Wever-Pinzon Omar 
Published: October 2024

Heart failure (HF) involves global genome modifications. Adverse structural and function remodeling that occurs in HF was initially considered to be irreversible. However, ~15% of HF patients on left ventricular assist device (LVAD) support show significant structural and functional reverse remodeling, distinguishing them as responders (R), while ~85% are non-responders (NR). DNA methylation and transcriptional changes that exert myocardial recovery is not well understood.
To address this, we performed whole-genome bisulphite sequencing and RNA sequencing on paired myocardial biopsies from HF patients (n=84) before (pre-LVAD) and after LVAD unloading (post-LVAD).

Post-LVAD samples showed activation of pathways including TGFβ signaling, PTEN and Fatty acid oxidation compared to pre. Integrating DNA methylation and transcriptomics data revealed hypomethylation (upregulation) of genes including
Scaper, Frat1
and
Magi1
and hypermethylation (downregulation) of
Tpp3
and
Icam.
Overall, suggesting a unique ECM-specific stabilization pathway post-LVAD unloading.

Segregating samples based on their response to LVAD unloading, pathways such as inflammation and fibrotic signaling were activated in postNR compared to preNR. Hypomethylation of
Magi1
and hypermethylation of
Tppp3
was observed in postNR suggesting cross-linking proteins and destabilization of microtubule formation as potential mechanisms of functional regression in NR. Conversly, postR showed activation of deubiquitination, oxidative phosphorylation and NLR signaling compared to preR. Finally, we observed integrin signaling, syndecan interaction, collagen degradation and wound healing pathways were activated in postR compared to postNR. Hypomethylation of actin cytoskeleton (
Myl12a
), microtubule/motor proteins (
Kif5b
) and tropomyosin (
Tpm3
) were observed in postR, suggesting a plausible reverse remodeling mechanism mediated by ECM degradation and stabilization of myocardium in these patients. Western blot analysis also showed a trend towards an increase in collagen in postNR compared to postR (n=4, p=0.06). Finally, a mouse model of HF and recovery was used and pathways including ECM degradation and cardioprotective signaling were activated in mice that recovered from HF compared to mice that did not. Overall, our data suggests a unique ECM regulation pathway to contribute towards myocardial reverse remodeling in HF patients.