bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aerobic Exercise Training as a Potential Cardioprotective Strategy to Attenuate Doxorubicin-Induced Cardiotoxicity
Authors: Kouzi Samir A. , Uddin Mohammad Nasir 
Published: November 2016

Doxorubicin is one of the most commonly used cytotoxic anticancer drugs against several cancers. Although a highly effective anticancer drug, the clinical use of doxorubicin is severely limited by its cardiotoxicity which results in morbidity, poor quality of life, and premature mortality. Only very few clinically accepted methods to minimize doxorubicin-induced cardiac injury are available today, but none of them have proven to be completely successful. Due to limited alternative strategies, a number of potential cardioprotective therapies are currently being investigated for treating and/or preventing doxorubicin-induced cardiotoxicity. Of these potential strategies, aerobic exercise training is the only nonpharmacologic strategy that shows a great deal of promise. Although there are no published human clinical trials, evidence from numerous animal studies suggests that aerobic exercise training, administered prior to, during and/or following doxorubicin therapy, is protective against doxorubicin-induced cardiac injury. Protective properties of exercise training against the cardiotoxicity of doxorubicin have been attributed to a number of potential molecular mechanisms including: enhancing the production of endogenous antioxidant machineries; regulating proapoptotic signaling; stimulating the release, mobilization and homing of cardiac progenitor cells; limiting myocyte turnover; eliciting favorable adaptations in myocardial calcium handling and preventing calcium overload; modulating cardiac AMPK activity; downregulating cardiac autophagy/lysosomal signaling; and reducing myocardial doxorubicin accumulation. Further preclinical and clinical research is needed to decipher and refine the molecular mechanisms underlying the cardioprotective effects of exercise training, as well as to define the nature and magnitude of the effect of exercise on doxorubicin-induced cardiotoxicity in cancer patients. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
POTENTIALITY ASSESSMENT FOR ECOTOURISM DEVELOPMENT IN DIDA HARA CONSERVATION SITE OF BORENA NATIONAL PARK, ETHIOPIA
Authors: Nigatu Tesfaye Fentaw 
Published: November 2016

The main objective of this research is identifying the ecotourism resources and products for ecotourism development in the Dida Hara conservation site of BoranaNational Park, Oromia Regional State, Ethiopia. The study used a cross-sectional descriptive research design. Both qualitative and quantitative methods are used. The data were collected by using a questionnaire, interview, field observation and secondary document analysis. The questionnaire was distributed to the visitors in order to determine the market demand by using convenience sampling technique. Interview was conducted with office personnel’s, tour operators and selected local community representatives and selected by using non- probability sampling technique. The study revealed that Dida Hara conservation site of Borana National Park has potential ecotourism resources especially in terms of wildlife (more than 40 mammal species), birds (more than 280 bird species) and cultural resources (especially Borana community Gada system and Buna Qalla ceremony). The Park area is the centre of endemic birds like; Ethiopian Bush Crow, White-Tailed Swallow, Prince Ruspoil’s Turaco. The presence of such untapped ecotourism resources has also a potential for community participation including natural resources conservation and awareness for negative and positive impacts of ecotourism. The local communities are also positive towards ecotourism development in the destination. Based on the visitor's survey result more than 90 % are interested to view wildlife and birds and 86.5 % of the visitors are willing to recommend for others to visit the site. Besides these, the visitor's survey revealed that around 97.8 % of the respondents are considering themselves as ecotourist and willing to spend more money to eco-tourism destination (84.3) as compared to regular tourism destination. Furthermore, the study confirmed that the identification of ecotourism resources play a significant role in the development of ecotourism and for marketing the destination for the future. In this destination, no research has conducted in related with the potential resources for ecotourism development by using such multi-directional data collection tools including market demand analysis.
Development of Open Textbooks Learning Analytics System
Authors: Prasad Deepak , Totaram Rajneel , Usagawa Tsuyoshi 
Published: November 2016

<p class="3">Textbook costs have skyrocketed in recent years, putting them beyond the reach of many students, but there are options which can mitigate this problem. Open textbooks, an open educational resource, have proven capable of making textbooks affordable to students. There have been few educational development as promising as the development of open textbooks to lower costs for students. While the last five years have witnessed unparalleled interest and significant advances in the development and dissemination of open textbooks, one important aspect has, until now, remained unexplored: the praxis of learning analytics for extracting information regarding how learners interact and learn with open textbooks, which is crucial for their evaluation and iterative improvement process.</p><p class="3">Learning analytics offers a faster and more objective means of data collection and processing than traditional counterparts, such as surveys and questionnaires, and—most importantly—with their capability to provide direct evidence of learning, they present the opportunity to enhance both learner performance and environment. With such benefits on offer, it is hardly surprising that the optimism surrounding learning analytics is mounting. However, in practice, it has been pointed out that the technology to deliver its potential is still very much in its infancy, which is true in the case of open textbooks. Against this background, the main aim of our study was to develop a prototype open textbook learning analytics system to track individual learners’ online and offline interactions with their open textbooks in electronic publication (EPUB) format, and to present its developmental work as building blocks for future development in this area. We conclude with a discussion of the practical implications of our work and present directions for future work. </p>
A Far Cry from School History: Massive Online Open Courses as a Generative Source for Historical Research
Authors: Gallagher Silvia Elena , Wallace Ciaran 
Published: November 2016

<p class="3">Current research into Massive Online Open Courses (MOOCs) has neglected the potential of using learner comments for discipline-specific analysis. This article explores how MOOCs, within the historical discipline, can be used to generate, investigate, and document personal narratives, and argues that they serve as a rich platform for historical resource generation. Through these narratives, this research explores changing perceptions of learning; from learning history at school to learning about history in a MOOC. This exploration uses a qualitative thematic analysis of learner comments related to personal narratives of learning history at school from the Trinity College Dublin/Futurelearn “Irish Lives in War and Revolution: 1912-1923” MOOC. These personal narratives were generated both directly and indirectly through four pedagogical tools; reflective questions, multimedia resources, external links, and inter-learner interaction. Broad themes emerged from the analysis of personal narratives including attitudes toward history at school, biased and inadequate teaching, and MOOC teaching compared with school experiences. The analysis demonstrated that MOOCs serve as a generative repository for personal and family historical narratives, and described how MOOCs can change perceptions of teaching and learning history. This paper contributes a novel understanding of MOOCs for discipline-specific analysis, provides a framework for MOOC historical resource generation, and describes changing perceptions of learning from the perspective of MOOC learners. </p>
Extended Three-Phase Relative Permeability Formulation and its Application to the History-Matching of Multiple WAG Corefloods Under Mixed-Wet Conditions
Authors: Duchenne S. , de Loubens R. , Joubert T. 
Published: November 2016

Abstract
The interpretation of multiple water-alternating-gas (WAG) experiments carried out with different injection strategies (first injected fluid, lengths of injected slugs) is necessary to improve our understanding of WAG mechanisms and to build a reasonably predictive three-phase relative permeability model for reservoir simulation. This paper presents an extension to the well-known three-phase hysteresis model of Larsen & Skauge and its application to interpret an extensive series of WAG experiments carried out under mixed-wet conditions, on the same low permeability sandstone core, at three different levels of gas-oil interfacial tension (IFT), namely 0.04 (low), 0.15 (intermediate) and 2.7 mN.m−1(high).
After presenting the main experimental results, we describe an extended formulation – which was implemented in our in-house research reservoir simulator (IHRRS) – where the conventional Land formalism for the calculation of imbibition scanning curves and gas trapping is replaced by a more general model allowing arbitrary trapping functions and accounting for the nature of the displacing fluid (oil, water, or a mixture of both). This new approach – which is thought to be necessary for accurate modeling of WAG processes in mixed-wet systems and/or when gas-water and gas-oil IFTs differ significantly – is used within a history-matching workflow to generate multiple sets of fitting parameters consistent with the experimental data.
For each IFT, an experimental dataset consisting of a gasflood and two long slugs (&gt; 1 PV) WAG corefloods starting with either gas or water was history-matched. Each individual WAG coreflood was first interpreted together with the corresponding gasflood data, and then a simultaneous history-matching of all the coreflood data was attempted. An acceptable match of the experiments could only be obtained by restricting the common set of fitting parameters and by introducing a trapping model tuned to the experimental data and accounting for a different amount of trapped gas in the presence of an oil bank (observed in some experiments).
This work offers new insights on the methodology to follow and the physical aspects to be improved, such as the gas imbibition scanning curves under three-phase flow conditions, in order to build a more reliable three-phase hysteresis model, capable of predicting multiple injection strategies and applicable to different wettabilities and gas-oil IFTs.
DEVELOPMETRIC REPORT ON PROPERTIES OF AGGRESSIVE AND WARM-HEARTED DIRECTIVENESS SCALE (DAIS-R) AND ITS APPLICATION FOR MEASUREMENT OF PARENTAL COMMUNICATION STYLE
Authors: SZYMAŃSKA AGNIESZKA 
Published: November 2016

Istnieje wiele kontrowersji wokół definicji dyrektywności, jak również jej wpływu na interakcje międzyludzkie i interakcje rodzic–dziecko, która jest przedmiotem szczególnej troski w psychologii. W niniejszym artykule przedstawiono skalę DAiS-R, przeznaczoną do pomiaru dyrektywności rodzicielskiej. Skala DAiS-R została zbudowana, aby ocenić poziom i rodzaj dyrektywności, który jest zdefiniowany jako akt mowy, którego celem jest zachęcanie partnera do robienia czegoś. Wyłoniono dwa rodzaje dyrektywności: agresywną i serdeczną. Badania przeprowadzono na próbie składającej się z 977 osób. Trafność teoretyczna skali została zweryfikowana za pomocą konfirmacyjnej analizy czynnikowej. Skalę cechuje wysoka rzetelność. Dyrektywność serdeczna i agresywna są skorelowane ujemnie. Skala DAiS-R nie jest skorelowana ze Skalą Dyrektywności Raya. Skala ma zastosowanie do oceny stylu komunikacji rodziców. Prowadzone wcześniej badania ujawniły, że na podstawie wyników rodziców uzyskiwanych w skali można przewidzieć zachowanie dziecka w przedszkolu. Analiza potwierdziła nie tylko przydatność skali, lecz także zdecydowanie wykazała istotny wpływ rodzicielskiego stylu komunikacji na zachowanie dzieci.
ANTYWYCHOWAWCZA FUNKCJA ROZRYWKOWYCH MEDIÓW MŁODZIEŻOWYCH WYZWANIEM KATECHETYCZNYM
Authors: Małek Michał Konrad 
Published: November 2016

Rozrywkowy charakter mediów młodzieżowych sprawia, że ich odbiorcy przyjmują w sposób bezrefleksyjny występujące tam, silnie zideologizowane treści. Po 1989 r. większa część mediów kierowanych do młodzieży porusza błahą tematykę, występuje w nich coraz większa homogenizacja treści, co samo w sobie stanowi zagrożenie dla rozwoju młodych odbiorców. Uczą postaw konsumpcyjno – utylitarnych w każdej dziedzinie życia. Przedstawianie w nich tematyki seksualnej wypacza obraz seksualności człowieka w umysłach odbiorców. Stosowane techniki manipulacji: ingracjacja i fragmentacjapozwalają tym mediom kształtować niekompletny obraz świata i przyśpieszają erozję wartości podstawowych w życiu młodego pokolenia. Rozrywkowe media młodzieżowe wykorzystują cechy psychiczne swoich adresatów do manipulowania i czynienia z nich stałych odbiorców. Media audiowizualne chociaż posiadają oznaczenia wiekowe programów, to przez swój styl zdają się zachęcać młodzież do oglądania niedozwolonych treści. Przegląd wybranych programów pozwala dostrzec, że nie można rozpatrywać ich inaczej jak w kluczu antywychowania. Działanie rozrywkowych mediów młodzieżowych wydaje się być celowe, aby przygotować rynek zbytu dla równie infantylnych mediów kierowanych już do dorosłych. Wartości, które przekazują te media nie mają na celu integralnego rozwoju odbiorców i stanowią antynomię wychowania. Działania katechetyczno-duszpasterskie powinny być ukierunkowane na przeciwdziałanie antywychowaniu promowanemu przez media komercyjne dla młodzieży.
Associations Between Anxiety Disorder Diagnoses and Body Mass Index Differ by Age, Sex and Race: A Population Based Study
Authors: DeJesus Ramona S. , Breitkopf Carmen R. , Ebbert Jon O. , Rutten Lila J. Finney , Jacobson Robert M. , Jacobson Debra J. , Fan Chun , St. Sauver Jennifer 
Published: November 2016

Background:
Few large studies have examined correlations between anxiety and body mass index (BMI) by gender or racial groups using clinical data.

Objective:
This study aimed to determine associations between diagnosed anxiety disorders and BMI, and evaluate whether observed associations varied by demographic characteristics.

Method:
Data from the Rochester Epidemiology Project (REP) data linkage system were analyzed to examine associations between anxiety disorders and BMI among adults ages 18-85 residing in Olmsted County, MN in 2009 (n=103,557). Height and weight data were available for 75,958 people (73%). The international classification of underweight, overweight, and obesity by BMI was used.

Results:
Population consisted of 56% females, 92.8% White individuals, with median age of 46 years. When adjusted for age, sex, and race, we observed a U-shaped association between anxiety and BMI group. Underweight and obese individuals were more likely to have an anxiety diagnosis compared to normal weight individuals. Stratification by sex yielded a U-shaped association between anxiety and BMI only in women. Stratification by race showed a U-shaped association between anxiety and BMI only in the White population. Anxiety was significantly associated only with obesity in the Black population. Anxiety was not associated with a BMI category in Asian or Hispanic groups. Among elderly group, there is inverse correlation between anxiety and obesity.

Conclusion:
Our results suggest that anxiety may have heterogeneous associations with BMI in the population. Further research on potential mechanisms contributing to these findings will help direct efforts in anxiety and obesity management across diverse population groups.
Detection of Specific Antibody Reactivity to Toxocara Larval Excretory-secretory Antigens in Asthmatic Patients (5-15 Years)
Authors: Mosayebi Mahdi , Moini Latif , Hajihossein Reza , Didehdar Mojtaba , Eslamirad Zahra 
Published: November 2016

Background & Purpose:
Humans act as an intermediate host for Toxocara canis and Toxocara cati. Toxocara may be an important risk factor for asthma in humans. The aim of the present study was to evaluate immunoglobulin G (IgG) anti-Toxocara canis antibody, using enzyme-linked immunosorbent assay (ELISA) in asthmatic patients (aged 5-15 years), referring to a clinic of pulmonary diseases in Arak, Iran.

Materials & Methods:
In this bi-group cross sectional study, serum samples were collected from 110 children with confirmed asthma and 70 children without asthma within one year. IgG anti-Toxocara antibody was detected via ELISA method. The collected data were analyzed, using SPSS.

Results:
The seroprevalence of antibodies against Toxocara species was estimated at 1.8% (two males) in asmathic children via ELISA method; however, no antibodies against Toxocara canis were detected in the control group. There was no significant correlation between the frequency of antibodies against Toxocara and variables such as age, gender, or place of residence (P>0.05). Moreover, the frequency of antibodies against Toxocara was not significantly correlated with contact with dogs, consumption of unwashed fruits and vegetables, or use of raw/undercooked sheep liver (P>0.05).

Conclusion:
The present study showed anti-Toxocara antibody in 1.8% of asthmatic children and determined the seroprevalence of toxocariasis in asthmatic children and adolescents in Arak, Iran. Based on the findings, the low rate of infection with Toxocara among asthmatic children may be attributed to acceptable personal hygiene and religious considerations.
Biomechanical assessment of the effects of vertebral distraction-fusion techniques on the adjacent segment of canine cervical vertebrae
Authors: Hakozaki Takaharu , Ichinohe Tomu , Kanno Nobuo , Yogo Takuya , Harada Yasuji , Inaba Tadashi , Kasai Yuichi , Hara Yasushi 
Published: November 2016

Abstract
OBJECTIVE To assess effects of vertebral distraction-fusion techniques at a treated segment (C5-C6) and an adjacent segment (C4-C5) of canine cervical vertebrae.
SAMPLE Cervical vertebrae harvested from cadavers of 10 skeletally mature Beagles.
PROCEDURES Three models (intact, titanium plate, and polymethylmethacrylate [PM MA]) for stabilization of the caudal region of the cervical vertebrae (C4 through C7) were applied to the C5-C6 vertebral segment sequentially on the same specimens. Biomechanical assessments with flexion-extension, lateral bending, and axial rotational tests were conducted after each procedure. Range of motion (ROM) for a torque load applied with a 6-axis material tester was measured at C4-5 and C5-6 and calculated by use of a 3-D video measurement system.
RESULTS In both the plate and PMMA models, ROM significantly increased at C4-5 and significantly decreased at C5-6, compared with results for the intact model. The ROM at C5-6 was significantly lower for the plate model versus the PMMA model in lateral bending and for the PMMA model versus the plate model in axial rotation. Conversely, ROM at C4-5 was significantly higher in axial rotation for the PMMA model versus the plate model. No significant differences were identified in flexion-extension between the PMMA and plate models at either site.
CONCLUSIONS AND CLINICAL RELEVANCE Results of this study suggested that vertebral distraction and fusion of canine vertebrae can change the mechanical environment at, and may cause disorders in, the adjacent segment. Additionally, findings suggested that effects on the adjacent segment differed on the basis of the fusion method used.
Feasibility, repeatability, and safety of ultrasound-guided stimulation of the first cervical nerve at the alar foramen in horses
Authors: Mespoulhès-Rivière Céline , Brandenberger Olivier , Rossignol Fabrice , Robert Céline , Perkins Justin D. , Marie Jean-Paul , Ducharme Norm 
Published: November 2016

Abstract
OBJECTIVE To develop and assess the feasibility, repeatability, and safety of an ultrasound-guided technique to stimulate the first cervical nerve (FCN) at the level of the alar foramen of the atlas of horses.
ANIMALS 4 equine cadavers and 6 clinically normal Standardbreds.
PROCEDURES In each cadaver, the FCN pathway was determined by dissection, and any anastomosis between the first and second cervical nerves was identified. Subsequently, each of 6 live horses underwent a bilateral ultrasound-guided stimulation of the FCN at the alar foramen 3 times at 3-week intervals. After each procedure, horses were examined daily for 5 days.
RESULTS In each cadaver, the FCN passed through the alar foramen; a communicating branch between the FCN and the accessory nerve and anastomoses between the ventral branches of the FCN and second cervical nerve were identified. The anastomoses were located in the upper third of the FCN pathway between the wing of the atlas and the nerve's entry in the omohyoideus muscle. Successful ultrasound-guided electrical stimulation was confirmed by twitching of the ipsilateral omohyoideus muscle in all 6 live horses; this finding was observed bilaterally during each of the 3 experimental sessions. No complications developed at the site of stimulation.
CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that ultrasound-guided stimulation of the FCN at the alar foramen appears to be a safe and straightforward procedure in horses. The procedure may have potential for use in horses with naturally occurring recurrent laryngeal neuropathy to assess reinnervation after FCN transplantation or nerve-muscle pedicle implantation in the cricoarytenoideus dorsalis muscle.
Prior exposure to freezing stress enhances the survival and recovery of Poa pratensis exposed to severe drought
Authors: Kong Ricky S. , Henry Hugh A. L. 
Published: November 2016

PREMISE OF THE STUDY:Both freezing and drought cause cellular dehydration, and they elicit similar increases in protective compounds, which suggests that these stresses could potentially interact. We examined whether the physiological changes that occur in response to freezing in the fall and spring could affect subsequent survival and growth after summer drought.METHODS:We froze Poa pratensis tillers in the late fall, early spring, or late spring at 0, −5, or −10°C for 3 d and then subjected them to no drought (−0.025 MPa), moderate drought (−0.140 MPa), or severe drought (−0.250 MPa) for 3 wk in the summer. We quantified survival and total biomass after a 3‐wk recovery period, and we determined leaf soluble sugar concentrations before and then 0, 30, and 55 d after freezing.KEY RESULTS:For survival and biomass, there were significant interactions between freezing and drought. Spring frozen tillers had the highest biomass and survival following severe drought, whereas fall freezing did not significantly increase the biomass of tillers following the severe drought. Increased drought tolerance after spring freezing did not appear to be associated with increased soluble sugar content, given that the freezing effects on leaf glucose, fructose, and sucrose content were absent 55 d post freezing.CONCLUSIONS:Our results demonstrate that multiple stresses that occur over different seasons can interact; this interaction is highly relevant to herbaceous species in northern temperate regions that are experiencing more intense and frequent stress as a result of changes in snow cover and extreme climatic events.