bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition
Authors: Gaggianesi Miriam , Turdo Alice , Chinnici Aurora , Lipari Elisa , Apuzzo Tiziana , Benfante Antonina , Sperduti Isabella , Di Franco Simone , Meraviglia Serena , Lo Presti Elena , Dieli Francesco , Caputo Valentina , Militello Gabriella , Vieni Salvatore , Stassi Giorgio , Todaro Matilde 
Published: April 2017

Abstract
The tumor microenvironment supplies proinflammatory cytokines favoring a permissive milieu for cancer cell growth and invasive behavior. Here we show how breast cancer progression is facilitated by IL4 secreted by adipose tissue and estrogen receptor–positive and triple-negative breast cancer cell types. Blocking autocrine and paracrine IL4 signaling with the IL4Rα antagonist IL4DM compromised breast cancer cell proliferation, invasion, and tumor growth by downregulating MAPK pathway activity. IL4DM reduced numbers of CD44+/CD24− cancer stem-like cells and elevated expression of the dual specificity phosphatase DUSP4 by inhibiting NF-κB. Enforced expression of DUSP4 drove conversion of metastatic cells to nonmetastatic cells. Mechanistically, RNAi-mediated attenuation of DUSP4 activated the ERK and p38 MAPK pathways, increased stem-like properties, and spawned metastatic capacity. Targeting IL4 signaling sensitized breast cancer cells to anticancer therapy and strengthened immune responses by enhancing the number of IFNγ-positive CTLs. Our results showed the role of IL4 in promoting breast cancer aggressiveness and how its targeting may improve the efficacy of current therapies. Cancer Res; 77(12); 3268–79. ©2017 AACR.
Combined Genetic Biomarkers and Betel Quid Chewing for Identifying High-Risk Group for Oral Cancer Occurrence
Authors: Chung Chia-Min , Lee Chien-Hung , Chen Mu-Kuan , Lee Ka-Wo , Lan Cheng-Che E. , Kwan Aij-Lie , Tsai Ming-Hsui , Ko Ying-Chin 
Published: April 2017

AbstractWe integrated genetic risk scores (GRS) and environmental factors for identifying high-risk subjects for oral squamous cell carcinoma (OSCC) occurrence by using case–control study. A total of 447 patients diagnosed with OSCC and 580 unrelated subjects were recruited from two medical centers in Taiwan. A multinomial logistic regression model was conducted to access interaction between GRS and betel quid (BQ) chewing. We employed ROC curve to compare the accuracy of OSCC occurrence. Four tag SNPs were found in NOTCH1, BRCA1, COL9A1, and HSPA13 genes that were significantly associated with OSCC occurrence. GRS was calculated by the four tag SNP risk alleles. The higher GRS (scores = 4) remained independently associated with risk of OSCC after adjustment for age, the use of alcohol, BQ, and cigarette: adjusted OR = 4.42 [95% confidence interval (95% CI), 1.34–14.55]. The GRS and BQ chewing interaction showed an increased risk for OSCC occurrence with adjusting for other substance use and age (OR = 70.77; 95% CI, 8.70–575.73). The synergy index was 16.58 (95% CI, 2.27–70.56), suggesting a positive additive interaction between GRS and BQ chewing. The areas under the ROC curves (AUROC) were 0.91 for combined GRS and BQ chewing with sensitivity of 88.6% and specificity of 86.7%. The AUROC of GRS and BQ chewing is above 90%, which may be valuable in identifying high-risk subjects. Early screening can allow the clinician to provide the appropriate intervention and to reduce the OSCC occurrence. Cancer Prev Res; 10(6); 355–62. ©2017 AACR.
Matched Comparison of Self-Expanding Transcatheter Heart Valves for the Treatment of Failed Aortic Surgical Bioprosthesis
Authors: Alnasser Sami , Cheema Asim N. , Simonato Matheus , Barbanti Marco , Edwards Jeremy , Kornowski Ran , Horlick Eric , Wijeysundera Harindra C. , Testa Luca , Bedogni Francesco , Amrane Hafid , Walther Thomas , Pelletier Marc , Latib Azeem , Laborde Jean-Claude , Hildick-Smith David , Kim Won-Keun , Tchetche Didier , Agrifoglio Marco , Sinning Jan-Malte , van Boven Ad J. , Kefer Joëlle , Frerker Christian , van Mieghem Nicolas M. , Linke Axel , Worthley Stephen , Asgar Anita , Sgroi Carmelo , Aziz Mina , Danenberg Haim D. , Labinaz Marino , Manoharan Ganesh , Cheung Anson , Webb John G. , Dvir Danny 
Published: April 2017

Background—
Transcatheter valve-in-valve implantation is an established therapy for high-risk patients with failed surgical aortic bioprosthesis. There are limited data comparing outcomes of valve-in-valve implantation using different transcatheter heart valves (THV).

Methods and Results—

Patients included in the Valve-in-Valve International Data registry (VIVID) and treated with self-expanding THV devices were analyzed using centralized core laboratory blinded to clinical events. St. Jude Medical Portico versus Medtronic CoreValve were compared in a 1:2 fashion after propensity score matching. A total of 162 patients, Portico- (n=54) and CoreValve- (n=108) based valve-in-valve procedures comprised the study population with no significant difference in baseline characteristics (age, 79±8.2 years; 60% women; mean STS [Society of Thoracic Surgery] score 8.1±5.5%). Postimplantation, CoreValve was associated with a larger effective orifice area (1.67 versus 1.31 cm
2
;
P
=0.001), lower mean gradient (14±7.5 versus 17±7.5 mm Hg;
P
=0.02), and lower core laboratory–adjudicated moderate-to-severe aortic insufficiency (4.2% versus 13.7%;
P
=0.04), compared with Portico. Procedural complications including THV malpositioning, second THV requirement, or coronary obstruction were not significantly different between the 2 groups. Survival and stroke rates at 30 days were similar, but overall mortality at 1 year was higher among patients treated with Portico compared with CoreValve (22.6% versus 9.1%;
P
=0.03).

Conclusions—
In this first matched comparison of THVs for valve-in-valve implantations, Portico and CoreValve demonstrated differences in postprocedural hemodynamics and long-term clinical outcomes. Although this could be related to THV design characteristics, the impact of other procedural factors cannot be excluded and require further evaluation.
Saline-Induced Coronary Hyperemia
Authors: De Bruyne Bernard , Adjedj Julien , Xaplanteris Panagiotis , Ferrara Angela , Mo Yujing , Penicka Martin , Floré Vincent , Pellicano Mariano , Toth Gabor , Barbato Emanuele , Duncker Dirk J. , Pijls Nico H.J. 
Published: April 2017

Background—
During thermodilution-based assessment of volumetric coronary blood flow, we observed that intracoronary infusion of saline increased coronary flow. This study aims to quantify the extent and unravel the mechanisms of saline-induced hyperemia.

Methods and Results—

Thirty-three patients were studied; in 24 patients, intracoronary Doppler flow velocity measurements were performed at rest, after intracoronary adenosine, and during increasing infusion rates of saline at room temperature through a dedicated catheter with 4 lateral side holes. In 9 patients, global longitudinal strain and flow propagation velocity were assessed by transthoracic echocardiography during a prolonged intracoronary saline infusion. Taking adenosine-induced maximal hyperemia as reference, intracoronary infusion of saline at rates of 5, 10, 15, and 20 mL/min induced 6%, 46%, 111%, and 112% of maximal hyperemia, respectively. There was a close agreement of maximal saline- and adenosine-induced coronary flow reserve (intraclass correlation coefficient, 0.922;
P
<0.001). The same infusion rates given through 1 end hole (n=6) or in the contralateral artery (n=6) did not induce a significant increase in flow velocity. Intracoronary saline given on top of an intravenous infusion of adenosine did not further increase flow. Intracoronary saline infusion did not affect blood pressure, systolic, or diastolic left ventricular function. Heart rate decreased by 15% during saline infusion (
P
=0.021).

Conclusions—
Intracoronary infusion of saline at room temperature through a dedicated catheter for coronary thermodilution induces steady-state maximal hyperemia at a flow rate ≥15 mL/min. These findings open new possibilities to measure maximal absolute coronary blood flow and minimal microcirculatory resistance.
Regional Retrieval Processor for Direct Broadcast High-Resolution Infrared Data
Authors: Antonelli Paolo , Revercomb Henry E. , Giuliani Graziano , Cherubini Tiziana , Businger Steven , Lyman Ryan , Tjemkes Stephen , Stuhlmann Rolf , Moncet Jean-Luc 
Published: April 2017

AbstractThe Space Science Engineering Center, in collaboration with the Mauna Kea Weather Center at the University of Hawai’i at Mānoa, has developed a regional retrieval processor for high-spectral-resolution infrared data. The core of the processor makes use of an inversion system, referred to as Mirto, which combines, in a Bayesian way, the a priori knowledge of the atmospheric state, based on available numerical weather prediction forecasts, with the physical information embedded in satellite observations. Forecast temperature and water vapor mixing ratio fields over the central North Pacific Ocean are adjusted to produce synthetic radiances closer and closer to the Suomi NPP Cross-track Infrared Sounder (CrIS) observations taken in clear-sky conditions. The paucity of synoptic observations over this area and the highly homogeneous background represented by the ocean provide a good framework for the implementation of this hyperspectral data inversion system. Nearly real-time (less than 60 min from overpass time) Internet publication of retrieved atmospheric profiles is made possible by the availability of a direct broadcast system that provides data from the Suomi NPP platform (CrIS and VIIRS). The main goal for the implemented system is to provide the forecasting community with products suitable for nowcasting applications and for optimal data assimilation. The implemented processor has been running routinely since August 2013. Validation based on the comparisons of retrievals with rawinsonde data from Hilo, Hawaii, and Lihue, Hawaii, and GPS-derived total precipitable water from four stations, performed over a time period of more than 1 year, shows a statistically significant improvement on the background atmospheric state used as a priori information.
Striking Seasonality in the Secular Warming of the Northern Continents: Structure and Mechanisms
Authors: Nigam Sumant , Thomas Natalie P. , Ruiz-Barradas Alfredo , Weaver Scott J. 
Published: April 2017

The linear trend in twentieth-century surface air temperature (SAT)—a key secular warming signal—exhibits striking seasonal variations over Northern Hemisphere continents; SAT trends are pronounced in winter and spring but notably weaker in summer and fall. The SAT trends in historical twentieth-century climate simulations informing the Intergovernmental Panel for Climate Change’s Fifth Assessment show varied (and often unrealistic) strength and structure, and markedly weaker seasonal variation. The large intra-ensemble spread of winter SAT trends in some historical simulations was surprising, especially in the context of century-long linear trends, with implications for the detection of the secular warming signal. The striking seasonality of observed secular warming over northern continents warrants an explanation and the representation of related processes in climate models. Here, the seasonality of SAT trends over North America is shown to result from land surface–hydroclimate interactions and, to an extent, also from the secular change in low-level atmospheric circulation and related thermal advection. It is argued that the winter dormancy and summer vigor of the hydrologic cycle over middle- to high-latitude continents permit different responses to the additional incident radiative energy from increasing greenhouse gas concentrations. The seasonal cycle of climate, despite its monotony, provides an expanded phase space for the exposition of the dynamical and thermodynamical processes generating secular warming, and an exceptional cost-effective opportunity for benchmarking climate projection models.
Diagnosing Sarcopenia in Male Patients With Cirrhosis by Dual‐Energy X‐Ray Absorptiometry Estimates of Appendicular Skeletal Muscle Mass
Authors: Belarmino Giliane , Gonzalez Maria Cristina , Sala Priscila , Torrinhas Raquel Susana , Andraus Wellington , D’Albuquerque Luiz Augusto Carneiro , Pereira Rosa Maria R. , Caparbo Valéria F. , Ferrioli Eduardo , Pfrimer Karina , Damiani Lucas , Heymsfield Steven B. , Waitzberg Dan L. 
Published: April 2017

AbstractBackground: Ascites in cirrhotic patients interfere with accurate assessment of skeletal muscle when diagnosing sarcopenia. We hypothesized measurement of appendicular skeletal muscle index (ASMI) with dual‐energy x‐ray absorptiometry (DXA) improves the diagnosis of sarcopenia in cirrhotic patients as ASMI does not include the fluid‐filled abdominal compartment. Objective: To evaluate if ASMI is influenced by ascites, lower limb edema (LLE) and predicts mortality alone or combined with handgrip strength (HGS) in cirrhotic patients. Design: ASMI, HGS, and 36‐month mortality were obtained in 144 men with cirrhosis. ASMI was compared before and after paracentesis in 20 men with ascites and to results from 20 matched controls. The prognostic value of ASMI alone and with HGS was tested in a survival. Survival probabilities were obtained for sarcopenia diagnosed by standard ASMI and HGS European Working Group on Sarcopenia in Older People (EWGSOP) cutoffs and a new cutoff calculated from our ASMI + HGS tertiles. Results: ASMI did not change after paracentesis, was lower in patients than in controls (P < .001), and was not influenced by LLE (D = 0.30 kg/m2, P = .068; R2 = 2.40%). Mortality was influenced by ASMI and HGS (Pinteraction = 0.028). Sarcopenia diagnosed by EWGSOP was also diagnosed by our new cutoff; both predicted mortality with the latter more sensitive for mortality risk prediction (P = .011). Conclusions: DXA‐measured ASMI is not influenced by ascites or LLE in cirrhotic patients; can diagnose low skeletal muscle/sarcopenia; and predicts mortality, particularly when combined with HGS.
Changes in anxiety and depression symptoms associated to the outcome of MOH: A post-hoc analysis of the Comoestas Project
Authors: Bottiroli Sara , Allena Marta , Sances Grazia , De Icco Roberto , Avenali Micol , Fadic Ricardo , Katsarava Zaza , Lainez Miguel JA , Goicochea Maria Teresa , Jensen Rigmor Højland , Nappi Giuseppe , Tassorelli Cristina ,   the Comoestas Consortium
Published: April 2017

Aims To evaluate the impact of treatment success on depression and anxiety symptoms in medication-overuse headache (MOH) and whether depression and anxiety can be predictors of treatment outcome. Methods All consecutive patients entering the detoxification program were analysed in a prospective, non-randomised fashion over a six-month period. Depression and anxiety were assessed using the Hospital Anxiety and Depression Scale. Results A total of 663 MOH patients were evaluated, and 492 completed the entire protocol. Of these, 287 ceased overuse and reverted to an episodic pattern (responders) and 23 relapsed into overuse. At the final evaluation, the number of patients with depressive symptoms was reduced by 63.2% among responders ( p < 0.001) and did not change in relapsers ( p = 0.13). Anxious symptomatology was reduced by 43.1% in responders ( ps < 0.001) and did not change in relapsers ( p = 0.69). At the multivariate analysis, intake of a prophylactic drug and absence of symptoms of depression at six months emerged as prognostic factors for being a responder (OR 2.406; p = 0.002 and OR 1.989; p = 0.019 respectively), while lack of antidepressant drugs and presence of symptoms of depression at six months were prognostic factors for relapse into overuse (OR 3.745; p = 0.004 and OR 3.439; p = 0.031 respectively). Conclusions Symptomatology referred to affective state and anxiety can be significantly reduced by the treatment of MOH. Baseline levels of depression and anxiety do not generally predict the outcome at six months. Their persistence may represent a trait of patients with a negative outcome, rather than the consequence of a treatment failure.
US farm workers: What drives their job retention and work time allocation decisions?
Authors: Luo Tianyuan , Escalante Cesar L 
Published: April 2017

AbstractThis article investigates the time allocation choices of US workers between farm work and other job alternatives. Results indicate that green card farm workers tend to allocate fewer workweeks to farm employment than citizens and undocumented workers, in favour of better opportunities in the non-farm sector. There is evidence of an assimilation effect, whereby undocumented workers also tend to re-allocate their time from farm to non-farm employment as their residence tenure increases, even though they experience constrained mobility and visibility during periods of strict immigration control. In the context of employers’ violations of the existing labour laws that currently protect even the rights of undocumented workers, such turnover decisions seem justified. The findings raise concerns about whether any governmental effort to legalise the immigration status of such workers would reduce farm job turnover rates and increase farm employment retention, so long as labour standards are not enforced. Moreover, external economic shocks could more easily induce citizen and green card farm workers to abandon farm employment, whereas undocumented workers tend to remain in their farm jobs during such difficult times.
Treating Mental Illness Among Diabetic Black Male Adolescents
Authors: Banks Andrae , Fields Lashawnda , O’Dwyer Curtis , Scott Marquisha Lawrence , Joe Sean 
Published: April 2017

Objective: To examine randomized controlled trials (RCTs) for treatment evidence for Black male adolescents suffering from comorbid mental illness and diabetes mellitus. Method: A review of the studies published in English-language journals was conducted. Results: We found no RCT focused on Black males with diabetes mellitus Type 2 (DMT2). However, we found RCT inclusive of Black male adolescents with diabetes mellitus Type 1 (DMT1). Multisystemic therapy appears to be the best supported overall treatment for DMT1 management and psychosocial functioning followed by an enhanced form of behavioral family systems therapy for diabetics. Metformin was the only treatment in this review noted for use within DMT2. Metformin and a nursing-based telephone case management intervention realized utility as secondary services. Conclusions: There are gaps present for what effectively treats comorbid mental illness and DMT2 in Black male adolescents. For comorbid mental illness and DMT1, there are gaps in additional efficacious treatments, effectiveness across conditions, and effect duration beyond 24 months.
Safety and Efficacy of Intra-articular Injection of Platelet-Rich Plasma in Patients With Ankle Osteoarthritis
Authors: Fukawa Taisuke , Yamaguchi Satoshi , Akatsu Yorikazu , Yamamoto Yohei , Akagi Ryuichiro , Sasho Takahisa 
Published: April 2017

Background: An intra-articular injection of platelet-rich plasma (PRP) may be an effective treatment for osteoarthritis (OA). However, its efficacy in ankle OA has not been investigated yet. The purpose of this study was to assess the safety and efficacy of an intra-articular injection of PRP in patients with ankle OA during a 24-week period. Methods: Twenty ankles of 20 patients with varus-type ankle OA who received intra-articular injections of PRP were evaluated. PRP was extracted from whole blood by using the double-spin technique. Three injections of 2-mL PRP were administered to the ankle at an interval of 2 weeks under ultrasonographic guidance. Adverse events and efficacy were assessed at 4, 12, and 24 weeks after the last injection. Clinical outcomes were assessed by using the visual analog scale (VAS) for pain, the Japanese Society for Surgery of the Foot (JSSF) ankle/hindfoot scale, and the Self-Administered Foot Evaluation Questionnaire (SAFE-Q). Results: No serious adverse effects were observed during the follow-up period. The VAS and JSSF scale scores significantly decreased from baseline to 4, 12, and 24 weeks after treatment ( P < .001). The mean score in the pain-related subscale of the SAFE-Q significantly improved from baseline to 12 weeks after treatment ( P = .04). Overall, the amount of pain reduction was maximal at 12 weeks after the last injection, and the effect was reduced at 24 weeks. The patients with late-stage OA had worse scores in all outcomes than those with early-stage OA. Conclusion: Intra-articular injections of PRP resulted in no serious adverse effects and significantly reduced pain in the patients with ankle OA. PRP treatment can be safe and effective and may be an option in the treatment of ankle OA. Level of Evidence: Level IV, case series.
Polish Culture — Dry or Wet?
Authors: Zieliński Antoni 
Published: April 2017

The author argues against Harry Levine's “somewhat up-setting” classification of societies into temperance and non-temperance oriented cultures. This classification, he argues, does not apply to Poland as it is neither “dry” nor “wet”, which he illustrates by describing the development of sobriety movements in Polish territory in the 19th and 20th centuries. An important concept was the virtue of sobriety in Catholicism, which is not too distant from the Protestant doctrine. The temperance movement was significantly influential in contributing to the brisk decline of alcohol consumption during the second half of the 1800s. During the mid-war period consumption in Poland was among the lowest in Europe. Today there are two conflicting systems of convictions as regards alcohol: the older one relates to common sense (in which some situations are wet and some are dry) and the newer one (moral option) finds support from a scientific approach. In the deep layers of consciousness the old system is still resident, while on the surface, the new ethical and rational system is evident in current debate. This situation leads to a conflict of values on the family level.
Alcoholics Anonymous in Finland
Authors: Mäkelä Klaus 
Published: April 2017

The Finnish AA started early, and continues to be one of the strongest in Europe. The early growth was spectacular, and continued at a high and relatively stable pace in the 1960s and '70s. In the '80s, the growth rate decreased markedly, and in the early '90s there was almost a standstill. The Finnish AA is strong, autonomous and somewhat secluded, but not isolated. There is a strong emphasis on organizational independence, equality, and direct democracy, accentuated by the lack of non-alcoholics as trustees. Every group can also send their representative directly to the annual meetings. The AA meetings tend to be small, intimate and secluded. Circular seating arrangements, speaking in seating order and the lack of speakers' meetings symbolize the basic equality of all participants, in a way reminiscising radical Protestantism. Other parallels are the sparseness of rituals and the suspicious attitude to rhetoric skills and outward enthusiasm. Although AA has an easy access to most treatment institutions, it has not been intimately involved in the treatment system, and the public sales to non-members is insignificant. The organization is working smoothly, and there are no financial problems. But as a social movement, AA in Finland may stand at a watershed, destined as it is either to grow or recede.