bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conserved and Diverged Functions of the Calcineurin-Activated Prz1 Transcription Factor in Fission Yeast
Authors: Chatfield-Reed Kate , Vachon Lianne , Kwon Eun-Joo Gina , Chua Gordon 
Published: February 2016

Abstract
Gene regulation in response to intracellular calcium is mediated by the calcineurin-activated transcription factor Prz1 in the fission yeast Schizosaccharomyces pombe. Genome-wide studies of the Crz1 and CrzA fungal orthologs have uncovered numerous target genes involved in conserved and species-specific cellular processes. In contrast, very few target genes of Prz1 have been published. This article identifies an extensive list of genes using transcriptome and ChIP-chip analyses under inducing conditions of Prz1, including CaCl2 and tunicamycin treatment, as well as a ∆pmr1 genetic background. We identified 165 upregulated putative target genes of Prz1 in which the majority contained a calcium-dependent response element in their promoters, similar to that of the Saccharomyces cerevisiae ortholog Crz1. These genes were functionally enriched for Crz1-conserved processes such as cell-wall biosynthesis. Overexpression of prz1+ increased resistance to the cell-wall degradation enzyme zymolyase, likely from upregulation of the O-mannosyltransferase encoding gene omh1+. Loss of omh1+ abrogates this phenotype. We uncovered a novel inhibitory role in flocculation for Prz1. Loss of prz1+ resulted in constitutive flocculation and upregulation of genes encoding the flocculins Gsf2 and Pfl3, as well as the transcription factor Cbf12. The constitutive flocculation of the ∆prz1 strain was abrogated by the loss of gsf2+ or cbf12+. This study reveals that Prz1 functions as a positive and negative transcriptional regulator of genes involved in cell-wall biosynthesis and flocculation, respectively. Moreover, comparison of target genes between Crz1/CrzA and Prz1 indicate some conservation in DNA-binding specificity, but also substantial rewiring of the calcineurin-mediated transcriptional regulatory network.
Medicaid and CHIP Premiums and Access to Care: A Systematic Review
Authors: Saloner Brendan , Hochhalter Stephanie , Sabik Lindsay 
Published: February 2016

BACKGROUND:
Premiums are required in Medicaid and the Children’s Health Insurance Program in many states. Effects of premiums are raised in policy debates.

OBJECTIVE:
Our objective was to review effects of premiums on children’s coverage and access.

DATA SOURCES:
PubMed was used to search academic literature from 1995 to 2014.

STUDY SELECTION:
Two reviewers initially screened studies by using abstracts and titles, and 1 additional reviewer screened proposed studies. Included studies focused on publicly insured children, evaluated premium changes in at least 1 state/local program, and used longitudinal or repeated cross-sectional data with pre/postchange measures.

DATA EXTRACTION:
We identified 263 studies of which 17 met inclusion criteria.

RESULTS:
Four studies examined population-level coverage effects by using national survey data, 11 studies examined trends in disenrollment and reenrollment by using administrative data, and 2 studies measured additional outcomes. No eligible studies evaluated health status effects. Increases in premiums were associated with increased disenrollment rates in 7 studies that permitted comparison. Larger premium increases and stringent enforcement tended to have larger effects on disenrollment. At a population level, premiums reduce public insurance enrollment and may increase the uninsured rate for lower-income children. Little is known about effects of premiums on spending or access to care, but 1 study reveals premiums are unlikely to yield substantial revenue.

LIMITATIONS:
Effect sizes were difficult to compare across studies with administrative data.

CONCLUSIONS:
Public insurance premiums often increase disenrollment from public insurance and may have unintended consequences on overall coverage for low-income children.
Methods of Pedagogical Control of Motor Abilities Development in Seventh-Ninth Grade Boys
Authors: Іващенко О. В. , Єрмаков С. С. , Карпунець Т. В. , Крінін Ю. В. , Назаренко С. В. 
Published: February 2016

The research objective is to define methodological approaches to pedagogical control of the level of motor abilities development in middle schoolers.Materials and methods. To achieve the objectives set, the research relied on following methods used: analysis of scientific and methodological literature, pedagogical testing and methods of mathematical statistics. The participants in the study were 24 seventh grade boys, 17 eighth grade boys, and 17 ninth grade boys.Research results. The discriminant function can serve as a classifier for the age peculiarities of motor and functional readiness in seventh-ninth grade boys. The discriminant function equations allow to correctly classify 95.8% of the grouped data.The priority in the factor structure of readiness of the seventh grade boys belongs to the functional, coordination and strength readiness. For the eighth grade boys, it is functional, coordination and strength readiness, and for the ninth grade boys — strength, functional and coordination readiness.Conclusions. The final pedagogical control of motor and functional readiness of the seventh grade boys can use the first discriminant function with emphasis on the most informative variables. Such physical education can be considered effective if the results shown by the seventh grade boys are classified as results similar to those displayed by the eighth grade boys.In the final pedagogical control of motor and functional readiness in eighth grade boys, the reference point is the results of the ninth grade boys with emphasis on the most informative indicators of the discriminant function.
In the Labirinth. State, Governments, and the Growth of the Public Debt in Italy in the Middle of 1980s
Authors: Tedoldi Prof. Leonida 
Published: February 2016

<p>The ambition of this work is to rethink and present a possible path of historical-institutional investigation in relation to and with a critical comparison of now solid economic, political and sociological research into the political causes of the public debt and its instrumentalization by governments for the purposes of consensus, in a blocked political-institutional system. The reason for the decision to concentrate the analysis on a reduced portion of that decade – and therefore chronologically not going past 1988, the year of a passage to a different phase for many aspects – responds to the intention of further concentrating the analysis and delving into the sources. </p>
VARIAÇÃO DA MEDIDA TORÁCICA OBTIDA COM A FITA MÉTRICA TRADICIONAL COM FATOR DE CORREÇÃO E COM A FITA DE PESAGEM PARA BOVINOS
Authors: ABREU Bruno Almeida , MAGALHÃES Chrissia Jardim , DUAYER Enrico , MACHADO Sérgio Henrique Mattos , Silva Denise Aparecida 
Published: February 2016

<strong>Introdução: </strong>A<strong> </strong>estimativa do peso<strong> </strong>de bovinos pode ser realizada através do uso da fita torácica de pesagem ou com a fita métrica comum, devendo tal valor ser multiplicado por 2,8. O objetivo da pesquisa foi comparar os pesos obtidos com a fita métrica comum e o valor obtido através do uso da fita de pesagem desenvolvida especificamente para este fim em bovinos (fita torácica de pesagem). <strong>Material e métodos</strong>: A pesquisa foi realizada em São José do Calçado/ES em janeiro de 2015. No total foram estimados os pesos corporais de 20 fêmeas da raça Girolando com idade média de cinco meses com o uso da fita métrica comum e da fita torácica de pesagem para bovinos. <strong>Resultados: </strong>Os pesos corporais estimados através da fita métrica tradicional (X 2,8) variaram de 414,4 a 490 Kg com média equivalente a 454,4 ± 19,5 Kg. Com o uso da fita torácica de pesagem os pesos corporais apresentaram valores que variaram de 271 a 424 Kg com média igual a 346,7 ± 39,6 Kg. Os resultados apresentaram diferença significativa através da análise da variância com grau de confiança de 95%, propondo-se um novo fator de correção equivalente a 2,12. <strong>Conclusão: </strong>o fator de correção 2,8 não corresponde ao índice ideal a ser utilizado em novilhas em se tratando do peso corporal estimado através do uso de fita métrica comum, sendo mais significativo em comparação à fita torácica de pesagem o índice equivalente a 2,12; tal índice apresenta melhor aplicação em animais mais jovens.
TOXOPLASMOSE: UMA REVISÃO SISTEMÁTICA DOS FATORES DE RISCO RELATIVOS A INFECÇÃO TOXOPLÁSMICA EM CRIANÇAS NO BRASIL
Authors: Mangiavacchi Bianca Magnelli 
Published: February 2016

<p>A toxoplasmose é uma doença altamente prevalente em diversas regiões do mundo. Os fatores de risco relacionados com a aquisição da doença são bastante diversos, no entanto, ainda se sabe pouco sobre a soroprevalência da toxoplasmose em alguns grupos etários, entre estes as crianças. Este artigo propôs-se a realizar um revisão sistemática da literatura sobre os fatores de risco relacionados com infecção toxoplásmica em crianças. Observa-se que as maiores prevalências são encontradas em países de clima mais quente que se localizam entre os trópicos, fato que somado aos fatores de risco principais relacionados com a toxoplasmose, como a ingestão de oocistos e cistos teciduais, fazem com que a soroprevalência seja alta principalmente em áreas onde essas crianças vivam em precárias condições sanitárias. No entanto, ainda existem poucos trabalhos que relatam a identificação de fatores de risco relacionados com a infecção em crianças. Essa informação se faz necessária do ponto de vista de saúde pública e oferece subsídios para programas de prevenção da toxoplasmose inclusive para o controle da infecção congênita em adolescentes.<strong></strong></p>
Bussiness ethichs course and a proposal for artist oath in fine arts faculties
Authors: Ozer Ayhan 
Published: February 2016

Although format, purpose and method of art which is in the same age with the history of humanity showed significant changes from past to present and still is continuing to show changes, the main three elements which generated it have never changed. These ones are; artist, artwork and receiver. It is necessary to mention that these three constituent elements show significant changes just like art itself. Artist is the most effective one between them.As it would be wrong to say that artist is a tradesman by looking only business functions and value of the works; it will not resolve the subject to say not tradesman by just looking through the philosophy of art, either. Artistry is a high concept including being tradesman. It is not expected from a carpenter to react to social events or it cannot be criticized butcher's not to react to social events. An airplane pilot in the face of social events is not condemned for his opinions about the event and a jockey will not face with a reaction for not referring social events, either. Keywords: art, ethics, fine arts.
Our living handcraft meerschaum craftsmanship for the future
Authors: Ertürk Nilay , Varol Esra 
Published: February 2016

Meerschaum, which is an organic stone, has the appearance of soil or clay. It is white or similar to white in color. Meerschaum, which is a gemstone has absorbing characteristics, its color changes when exposed to open air, it is soft and easy to work magnesium silicate stone. New Works with high use and aesthetic values are produced from meerschaum, which is a completely unique material with its soft and sensitive structure as well as smoking material. Some of them are jewellery and accessories. The aim of this research is to introduce different meerschaum products in terms of aesthetic and use such as jewellery and accessories and to contribute to the development and introduction of this art. One of the places most suitable to mining and is determined as Eskisehir. Therefore, research sample is comprised of Eskisehir, meerschaum masters continuing to work in Eskisehir and their Works. Research is qualitative in terms of problem, data collection and analysis methods. Method of interview is used in collecting research data and Works are analyzed by being photographed.Keywords: Meerschaum, handcraft, accessories, jewellery
Investigation of social responsibility projects: A case study “every child matters”
Authors: Ermiş Yeşim 
Published: February 2016

Social responsibility projects are works done in order to raise awareness to masses, draw attention to problems in the community and find necessary measures and solutions.As well as printed materials such as posters, billboards and brochures, social responsibility projects can be delivered to masses via virtual environments and mass media. Visual design products are visual communication tools that can be perceived easily, are able to influence people from all parts of society, can be applied in all spaces and areas, are able to easily connect with a large audience simultaneously in a virtual environment.UNICEF, the United Nations International Children's Emergency Fund, is an organization specialized in supporting children's rights, add sustainability to children's rights as permanent ethical principles and provide international standards for children’s rights. The purpose of this study is to investigate the social responsibility project prepared by UNICEF for providing 2.2 Billion children around the world with every right using the slogan “Every child matters” in terms of elements of design discipline and pedagogical aspects such as clear and understandable design, reaching the target audience, use of correct images, psychological effects of colors used. Conclusion and recommendations were presented as a result of evaluations made regarding the findings of the study, which was conducted using qualitative research methods.Keywords: social responsibility project, unicef, design principles, graphic design, visual communication
Teaching technical specifications in fashion design education
Authors: Coruh Esen 
Published: February 2016

Technical specifications of the fashion designs should be made into written form to produce a clothing collection. Thus, the designer visualizes his/her idea using technical drawings. To fully realize his/her idea, it is important that the designer should provide the details regarding the technical specifications correctly. Because while a clothing collection is produced, it goes through many processes by different people. That the designer introduces technical specifications in detail provides accurate production of the collection.In this study, the fashion design process is gathered under fifteen headings as identification of target market, research of fashion trends, determination of concept, identification of colors, selection of fabrics, determination of auxiliary materials, description of line, preparation of concept board, illustration of clothing designs, drawing of technical designs, formation of measurement charts, description of sewing instructions, indication of measurements, preparation of patterns and computing costs. In addition to these headings, the technical specifications covering the process are also considered. Lastly, the suggestions on teaching of the technical specifications in fashion design education are presented. The aim of this study is the technical specifications in the fashion design process to be learned. Therefore, the suggestion for integration of the information that is learned during fashion design education which requires a long lasting infrastructure is presented. In fashion design education, it is important to provide education in design and production process. In this study the aim is to develop a model about teaching technical specifications in fashion design education. The aim of this study is to develop a model for teaching technical specifications in fashion design education. Therefore it is considered that the study is important in terms of integration of design and production information with related technical specifications.Keywords: Fashion design, fashion design education, technical specifications
Imaginations of creative design on the basis of sustainable design
Authors: Şatır Seçil 
Published: February 2016

Sustainability has emerged as the most current and striking concepts of the 2000’s. Every field, every subject, and every thought generated its sustainable counter part, and sustainability has come to symbolize the future. In fact, when sustainability researchers study design, they usually consider the sustainability of design.On the other hand, since it is of the essence of design, as in the essence of creativity, to conceive an original idea, to make new syntheses and to express them as an out of the ordinary image with seeable, tangible, olfactible, audible, and tasteable indicators, it is essential that the basic features of design should include knowledge about the future projections of design in the context of sustainability of design. Accordingly, it becomes a requisite to bring together all the information that is necessary to protect and sustain environments, habitats and nature that support life and evaluate it in shaping the future of product design and teach it as accumulated knowledge. Keywords: sustainable design, creativity, practices in education.
Permanence of an artwork in public areas and a design project: Draw and Erase (Yaz-Boz)
Authors: Çevik Arzu 
Published: February 2016

There are three elements that come to the forefront while questioning the permanence of an artwork: The artist who plays a role, although indirectly, in individuals' establishing a direct relationship with the artwork; the political authorities and city administrators who have effective power on the permanence of artworks, and the watchers/users who realize conscious or unconscious vandalistic behaviors to artworks in public areas. While, at times, emerging as a consequence of a systematic destruction of the cultural structure of societies and a dogmatic thinking, the vandalism can also emerge in the form of destructive actions of individuals provoked by psychological and sociological causes. Users who are consciously or unconsciously injurious behavior to the artwork in the public areas is starting point of the project. At the same time, this interactive project was born of necessity as a result of human – behavior – environment interaction. This project aims the protection of the artwork in public spaces and bring together people with interactive art. Keywords: public art, sculpture, vandalism, design, interactive Art
Arts and design education for sustainable development
Authors: Özsoy Vedat 
Published: February 2016

The UN General Assembly realized in 1983 that there was a heavy deterioration of the human environment and natural resources, and established the World Commission on Environment and Development (WCED). WCED's mission was to unite countries to pursue sustainable development together. This commission prepared a report called as “Our Common Future” in October 1987. The focus in the report was that the perspectives of society and nature are equal to that of economy.Countries’ economic and social development being sustainable, preventing global climate changes and natural disasters are directly proportionate to education strategies’ involving sustainability. Sustainability education is a model that aims to support the learners to become responsible citizens who struggle for a more sustainable world with their knowledge, skills, values and mental abilities. UNESCO indicates that “Education for Sustainable Development” allows every human being to acquire the knowledge, skills, attitudes and values necessary to shape a sustainable future.Art and design education has a multi-directional content for sustainable development ideals. For example, aesthetic sensitivity and critical thinking which are in the nature of art and design subjects, help students grow as individuals who are environment and ecosystem-sensitive. Sustainability of art and design education could be seen in two-directions. The first side is to keep students away from any kind of violence by providing them with sensitivity and empathy as well as help them develop respect for society and environment. In this way, students gain susceptibility and eagerness to protect ecosystem and live in the limits of nature. The second side is the sustainability projects carried out by students and instructors in art and design lessons. These are applications especially to clarify that a sustainable environment, nature and ecosystem is important for a sustainable life. This study includes some practical examples about the second side.Keywords: Sustainability, art and design education.
Harmonic analysis of the ensemble and singing pieces from Erdal Tugcular as an educational music composer
Authors: Bozkurt Hasan , Köse H. Seval 
Published: February 2016

Considered as one of Turkish new generation composers, Erdal Tugcular is today’s one of the strongest representatives of the folklorism in our Polyphonic Contemporary Turkish Music based on the Turkish Five. Musical pieces of Tugcular which are frequently heard in various national and international concert programs are of value and significance with their educational function at various levels of music education.This study harmonically analyses the pieces composed for Ensembles and Singing by Erdal Tugcular who has produced compositions in various styles and forms. For this purpose, “Osmanım” folk song composed for Singing with piano accompaniment and the polyphonic “Road tunes” piece composed for Ensemble were selected as samples among the compositions of Tugcular for Ensemble and Singing. The musical works selected are studied in terms of harmonic patterns and rules used in polyphonic singing.It is believed that the results of the study will contribute in the vocalization-rendition quality of the pieces analyzed and the realization of their educational functions. Keywords: Erdal Tugcular, ensemble pieces, singing pieces, harmonic analysis.
Association Between Plasma Uric Acid Levels and Cardiorenal Function in Adolescents With Type 1 Diabetes
Authors: Lytvyn Yuliya , Mahmud Farid H. , Daneman Denis , Deda Livia , Dunger David B. , Deanfield John , Dalton R. Neil , Elia Yesmino , Har Ronnie , Bradley Timothy J. , Slorach Cameron , Hui Wei , Moineddin Rahim , Reich Heather N. , Scholey James W. , Mertens Luc , Sochett Etienne , Cherney David Z.I. 
Published: February 2016

OBJECTIVE
The relationship between plasma uric acid (PUA) and renal and cardiovascular parameters in adolescents with type 1 diabetes (T1D) is not well understood. Our aims in this exploratory analysis were to study the association between PUA and estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (ACR), blood pressure, endothelial function, and arterial stiffness in T1D adolescents. These associations were also studied in healthy control (HC) subjects.

RESEARCH DESIGN AND METHODS
We studied 188 T1D subjects recruited to the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) and 65 HC subjects. Baseline PUA, eGFRcystatin C, ACR, blood pressure, flow-mediated dilation (FMD), and carotid-femoral pulse wave velocity (PWV) were measured.

RESULTS
PUA was lower in T1D vs. HC subjects (242 ± 55 vs. 306 ± 74 μmol/L, respectively; P &lt; 0.0001). Higher PUA was inversely associated with eGFR in T1D subjects (r = −0.48, P &lt; 0.0001) even after correction for baseline clinical demographic characteristics. PUA was not associated with ACR in T1D after adjustment for potential confounders such as eGFR. For cardiovascular parameters, PUA levels did not associate with systolic blood pressure, FMD, or PWV in T1D or HC subjects.

CONCLUSIONS
Even within the physiological range, PUA levels were significantly lower in T1D adolescent patients compared with HC subjects. There was an inverse relationship between PUA and eGFR in T1D, likely reflecting an increase in clearance. There were no associations observed with ACR, blood pressure, arterial stiffness, or endothelial function. Thus, in contrast with adults, PUA may not yet be associated with cardiorenal abnormalities in adolescents with T1D.