bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperbranched Vanillin‐Based Composite Coating: Achieve Efficient Icephobicity in High Humidity and Dynamic Environments
Authors: Wang Xiangzhao , Huang Xiaobin , Tian Linchuan , Ji Zemin , Sheng Haoqiang , Xu Shiyu , Li Xiaofei , Liu Hong 
Published: September 2024

AbstractDespite tremendous advancements in icephobic coating technology, icephobic efficacy frequently declines or completely disappears in low temperatures, high humidity, and dynamic environments. Here, a hyperbranched vanillin‐based composite coating with efficient icephobic properties (HVIC) is prepared by combining vanillin‐based phosphazene compounds with oil‐stored SiO2 through imine bonds‐ HVIC exhibits excellent hydrophobicity, with a water sliding angle of 9°. This coating's exceptional slippery performance imparts outstanding non‐adhesive, self‐cleaning characteristics, and deicing properties (τice: 8.2 kPa). It is noteworthy that HVIC performs exceptional anti‐icing and anti‐frosting in low‐temperature and high humidity environments. Compared with superhydrophobic coatings (SHC), the icing delay time of HVIC is 9.1 times that of SHC, and the frosting time is extended by roughly 300%. Most importantly, the HVIC‐treated propeller experienced two ice‐shedding events during the 200s dynamic icing test, while SHC completely lost its icephobic performance. This excellent dynamic icephobic performance can ensure the normal operation of the equipment while reducing energy consumption. The HVIC also exhibits significant UV shielding, antibacterial, flame retardant, self‐healing, and recyclability properties. The HVIC is regarded as having significant potential for application due to its easy and scalable approach.
Polyphenol‐Based Self‐Assembled Nanomedicine for a Three‐Pronged Approach to Reversing Tumor Immunosuppression
Authors: Li Zimu , Chen Zirui , Shi Kexin , Huang Ping , Zeng Wenfeng , Huang Qili , Peng Jingwen , Yang Li , Chen Hongzhong , Zhao Yanli , Zeng Xiaowei 
Published: September 2024

AbstractThe challenges of multi‐pathway immune resistance and systemic toxicity caused by the direct injection of immune checkpoint inhibitors are critical factors that compromise the effectiveness of clinical immune checkpoint blockade therapy. In this context, natural polyphenols have been employed as the primary component to construct a targeted and acid‐responsive PD‐L1 antibody (αPD‐L1) delivery nanoplatform. This platform incorporates garcinol, an inhibitor of the Nuclear Factor Kappa‐B (NF‐κB) signaling pathway, to regulate pro‐tumor immune escape cytokines and regulatory T cells. Additionally, the nanoplatform has been verified to induce immunogenic cell death (ICD), which promotes the maturation of dendritic cells and enhances the activity of cytotoxic T lymphocytes. In vivo and in vitro experimental results demonstrated that the nanoplatform can boost the immune response through a PD‐L1 and NF‐κB blocking/ICD inducing three‐pronged strategy, thereby effectively combating tumor growth and metastasis.
Single‐Atom Iridium Nanozyme‐Based Persistent Luminescence Nanoparticles for Multimodal Imaging‐Guided Combination Tumor Therapy
Authors: Li Yang , Wu Shu‐Qi , Nan Fang , Deng Wei , Li Kaixuan , Jarhen Nur , Zhou Yitong , Ma Qianli , Qu Yuanyuan , Chen Chaoxiang , Ren Yujing , Yin Xue‐Bo 
Published: September 2024

AbstractPersistent luminescence nanoparticles (PLNPs) can achieve autofluorescence‐free afterglow imaging, while near‐infrared (NIR) emission realizes deep tissue imaging. Nanozymes integrate the merits of nanomaterials and enzyme‐mimicking activities with simple preparation. Here PLNPs are prepared of Zn1.2Ga1.6Ge0.2O4:Cr0.0075 with NIR emission at 700 nm. The PLNPs are then incubated with IrCl3 solution, and the nanoparticles are collected and annealed at 750 °C to obtain iridium@PLNPs. Iridium is observed on the PLNPs at the atomic level as a single‐atom nanozyme with peroxidase‐like catalytic activity, photothermal conversion, and computed tomography (CT) contrast capability. After coating with exosome membrane (EM), the Ir@PLNPs@EM composite exhibits long‐lasting NIR luminescence, peroxidase‐like catalytic activity, photothermal conversion, and CT contrast capability, with the targeting capability and biocompatibility from EM. Thus, NIR afterglow/photothermal/CT trimodal imaging‐guided photothermal‐chemodynamic combination therapy is realized as validated with the in vitro and in vivo inhibition of tumor growth, while toxicity and side effects are avoided as drug‐free treatment. This work offers a promising avenue for advanced single‐atom nanozyme@PLNPs to promote the development of nanozymes and PLNPs for clinical applications.
Advancements in NADH Oxidase Nanozymes: Bridging Nanotechnology and Biomedical Applications
Authors: Li Dan , He Juyang , Ding Guanyu , Xin Yan , Feng Fan , Ma Shuaining , Lin Lu , Wang Erkang , Wang Jin 
Published: September 2024

AbstractNicotinamide adenine dinucleotide (NADH) oxidase (NOX) is key in converting NADH to NAD+, crucial for various biochemical pathways. However, natural NOXs are costly and unstable. NOX nanozymes offer a promising alternative with potential applications in bio‐sensing, antibacterial treatments, anti‐aging, and anticancer therapies. This review provides a comprehensive overview of the types, functional mechanisms, biomedical applications, and future research perspectives of NOX nanozymes. It also addresses the primary challenges and future directions in the research and development of NOX nanozymes, underscoring the critical need for continued investigation in this promising area. These challenges include optimizing the catalytic efficiency, ensuring biocompatibility, and achieving targeted delivery and controlled activity within biological systems. Additionally, the exploration of novel materials and hybrid structures holds great potential for enhancing the functional capabilities of NOX nanozymes. Future research directions can involve integrating advanced computational modeling with experimental techniques to better understand the underlying mechanisms and to design more effective nanozyme candidates. Collaborative efforts across disciplines such as nanotechnology, biochemistry, and medicine will be essential to unlock the full potential of NOX nanozymes in future biomedical applications.
Robust Electric‐Field Control of Colossal Exchange Bias in CrI3 Homotrilayer
Authors: Niu Yuting , Liu Zhen , Wang Ke , Ai Wanlei , Gong Tao , Liu Tao , Bi Lei , Zhang Gang , Deng Longjiang , Peng Bo 
Published: September 2024

AbstractControlling exchange bias (EB) by electric fields is crucial for next‐generation magnetic random access memories and spintronics with ultralow energy consumption and ultrahigh speed. Multiferroic heterostructures have been traditionally used to electrically control EB and interfacial ferromagnetism through weak/indirect coupling between ferromagnetic and ferroelectric films. However, three major bottlenecks (lattice mismatch, interface defects, and weak/indirect coupling in multiferroic heterostructures) remain, resulting in only a few tens of milli‐tesla EB field. Here, this study reports a robust electric‐field control recipe to dynamically tailor the EB effect in a pure CrI3 homotrilayer on a ferroelectric Y‐doped HfO2 (HYO) substrate, and demonstrate a colossal and tunable EB field (HE) from −0.15 to +0.33 T, giving rise to an EB modulation of 0.48 T. The charge doping due to ferroelectric HYO film divides a homo‐configuration of CrI3 homotrilayer into one antiferromagnetic (AFM) bilayer CrI3 and one ferromagnetic (FM) monolayer CrI3, favoring direct exchange coupling. The synergies of charge doping and electric field induce a transition of magnetic orders from AFM to FM phase in bilayer CrI3, which is also supported by first‐principles calculations, leading to the robust electric control of colossal EB effect. The results therefore open numerous opportunities for exploring 2D spintronics, memories, and braininspired in‐memory computing.
Lateral Heterostructures Fabricated via Artificial Pressure Gradient
Authors: Li Chen , Liu Ke , Yan Huacai , Zhang Long , Jiang Dequan , Wen Ting , Yue Binbin , Wang Yonggang 
Published: September 2024

AbstractHydrostatic conditions are generally pursued in high‐pressure research, maintained to prevent the intrinsic pressure gradient on the culets of diamond anvil cells (DACs) from introducing heterogeneity to the structure and physical properties of the regulated materials. Here, a pioneering route to fabricate lateral heterostructures is proposed via artificial pressure gradients intentionally designed in DACs. Under the tailored pressure gradients, different structural phases emerge in distinct parts of the material, resulting in the formation of heterostructures. Harnessing the polymorphic transition nature of violet phosphorus under high pressure, violet/blue and violet/black phosphorus lateral heterostructures with different electrical properties have been successfully prepared by the pressure gradient method. This achievement highlights the potential of artificial pressure gradients as a portable and universal strategy for the fabrication of lateral heterostructures, shedding new light on the preparation and regulation of lateral heterostructures across a wider range of materials.
Electrolyte Solvation Engineering Stabilizing Anode‐Free Sodium Metal Battery With 4.0 V‐Class Layered Oxide Cathode
Authors: Zou Yeguo , Zhang Baodan , Luo Haiyan , Yu Xiaoyu , Yang Meiling , Zheng Qizheng , Wang Junhao , Jiao Chenyang , Chen Yilong , Zhang Haitang , Xue Jiyuan , Kuai Xiaoxiao , Liao Hong‐Gang , Ouyang Chuying , Ning Ziyang , Qiao Yu , Sun Shi‐Gang 
Published: September 2024

AbstractAnode‐free sodium metal batteries (AFSMBs) are regarded as the “ceiling” for current sodium‐based batteries. However, their practical application is hindered by the unstable electrolyte and interfacial chemistry at the high‐voltage cathode and anode‐free side, especially under extreme temperature conditions. Here, an advanced electrolyte design strategy based on electrolyte solvation engineering is presented, which shapes a weakly solvating anion‐stabilized (WSAS) electrolyte by balancing the interaction between the Na+‐solvent and Na+‐anion. The special interaction constructs rich contact ion pairs (CIPs) /aggregates (AGGs) clusters at the electrode/electrolyte interface during the dynamic solvation process which facilitates the formation of a uniform and stable interfacial layer, enabling highly stable cycling of 4.0 V‐class layered oxide cathode from −40 °C to 60 °C and excellent reversibility of Na plating/stripping with an ultrahigh average CE of 99.89%. Ultimately, industrial multi‐layer anode‐free pouch cells using the WSAS electrolyte achieve 80% capacity remaining after 50 cycles and even deliver 74.3% capacity at −30 °C. This work takes a pivotal step for the further development of high‐energy‐density Na batteries.
Polyphenylene‐Based Anion Exchange Membranes with Robust Hydrophobic Components Designed for High‐Performance and Durable Anion Exchange Membrane Water Electrolyzers Using Non‐PGM Anode Catalysts
Authors: Liu Fanghua , Miyatake Kenji , Mahmoud Ahmed Mohamed Ahmed , Yadav Vikrant , Xian Fang , Guo Lin , Wong Chun Yik , Iwataki Toshio , Shirase Yuto , Kakinuma Katsuyoshi , Uchida Makoto 
Published: September 2024

AbstractAlkaline‐stable, highly conductive anion exchange membranes (AEMs) are attentively expected solid polymer electrolytes that contribute to achieving high performance and durability for anion exchange membrane water electrolyzers (AEMWEs). The technical challenges of AEMs mainly stem from the degradation of the polymer backbones, side chains, and anchoring cationic groups. Herein, new and stable AEMs (QTAF) are designed using 3,3′′‐dichloro‐2′,5′‐bis(trifluoromethyl)‐1,1′:4′,1′′‐terphenyl (TFP) monomers as the hydrophobic component incorporated into the polyphenylene backbone and 3,3′‐(2,7‐dichloro‐9H‐fluorene‐9,9‐diyl)bis(N,N‐dimethylpropane‐1‐amine) (AF) monomers as the hydrophilic component. After tuning the copolymer composition, the highest hydroxide ion conductivity (168.7 mS cm−1 at 80 °C) is achieved with the QTAF‐3.0 membrane. The QTAF‐3.0 membrane survives in harsh alkaline conditions (8 M KOH solution, 80 °C), with high conductivity (75.8 mS cm−1) after 810 h. A water electrolysis cell with QTAF‐3.0 membrane and non‐noble Ni0.8Co0.2O anode catalyst operates stably at a constant current density (1.0 A cm−2) for 1000 h with a negligible voltage increase rate of 1.1 µV h−1 after the initial voltage increase. The water electrolysis performance of the post‐tested QTAF‐3.0 cell is 1.83 V, only a 6.4% increase from the initial performance at 2.0 A cm−2, suggesting the high potential of the QTAF‐3.0 membrane for practical AEMWE applications.
Sound‐Based Assembly of Magnetically Actuated Soft Robots Toward Enhanced Release of Extracellular Vesicles
Authors: Gao Wei , Tognato Riccardo , Natta Micaela , Della Bella Elena , Cianciosi Alessandro , Serra Tiziano 
Published: September 2024

Magnetic soft robots have emerged as promising tools in biomedicine due to their wireless actuation, rapid response, and compatibility with biological systems. Despite the various innovative strategies proposed for their fabrication, they suffer from complex processes and limited cellular compatibility. Therefore, there is an urgent need to explore alternative approaches that are fast, mild, and highly tunable. Herein, a novel fabrication strategy for contactless assembly of soft‐robots is introduced for the first time. This technology exploits hydrodynamic instabilities at the free surface of a fluid layer, thus enabling the fabrication of centimeter‐scale robots featuring diverse structural properties. These features show a wide range of deformation modes in response to magnetic fields, including folding, bending, and expanding. Furthermore, the design and assembly of novel actuators with customized shapes as fish‐ and butterfly‐like structures is shown. The fabricated patterns exhibit different modes of motion under the influence of uniform magnetic fields. As a proof of concept, an innovative application of this technology combined with the proposed soft robots is represented by the enhanced release of extracellular vesicles. Altogether, this novel fabrication method along with the newly developed magnetic soft robots enables the manufacturing of high‐performance, multifunctional, and cytocompatible intelligent systems.
Defect Passivation of Mn2+‐Doped CsPbX3(X=Cl,Br) Perovskite Nanocrystals as Electrocatalyst for Overall Water Splitting
Authors: Zhou Haiyun , Li Pingping , Zhong Tingting , Teng Yunzhen , Li Siqi , Luo Xiaofeng , Wang Xinning , Yang Min , Deng Guowei 
Published: September 2024

AbstractMn doping has been used to improve the physical chemistry of lead halide perovskite nanocrystals such as CsPbX3, where X is a halogen ion. In this paper, a two‐phase method for Mn‐doped CsPbX3 nanosheets (where X=Br, Cl), namely water‐hexane system, is reported. Compared to conventional catalyst arrays, the band gap of CsPbBr3 nanocrystalline is easily tuned, the carrier diffusion distance is remote, the band edge position of the band structure is favorable for a wide range of electrocatalytic redox reactions, and the catalytic active site is maximally exposed, providing a larger electrolyte contact area. The porous hierarchical structure also accelerates the release of hydrogen bubbles. The results showed that the optimized Mn : CsPbBr3 catalyst exhibited excellent electrolytic performance of aquatic hydrogen in alkaline electrolyte (1 mol/L KOH). The overpotentials of the oxygen evolution reaction (OER) at the current densities of 10 and 100 mA cm−2 are only 114.4 and 505.4 mV, respectively, with a Tafel slope of 43 mV dec−1. At a current density of 10 mA cm−2, the excess potential required for the hydrogen evolution reaction (HER) is 158.6 mV and it exhibits excellent electrochemical stability. The Mn : CsPbBr3 nanocrystalline consists of two electrodes for hydrolysis of water, requiring only a voltage of 1.45 V. This provides implications for the optimization of electrocatalysts in alkaline electrolytes with the aim of developing next generation 2D electrocatalysts for overall water splitting.
Systemic immune‐inflammation index predicts short‐term mortality in acute ischemic stroke with severe stenosis of internal carotid artery associated pneumonia
Authors: Yang Yi , He Peng , Zhang Yongbo 
Published: September 2024

AbstractBackgroundWe aimed to investigate the relationship between systemic immune‐inflammation index (SII) and short‐term mortality in acute ischemic stroke (AIS) with internal carotid artery (ICA) severe stenosis and stroke associated pneumonia (SAP) patients.MethodsInformation on general demographic, laboratory data, CT angiography, magnetic resonance angiography, or digital subtraction angiography were obtained. The predictive power was evaluated by assessing the area under the receiver operating characteristic (ROC) curve. The logistic regression was performed to assess the association of SII and short‐term mortality in severe stenosis ICA‐AIS and SAP patients.ResultAmong 342 patients with severe stenosis ICA‐AIS and SAP, death occurred in 66 patients during 120 days follow‐up. Multivariate regression analyses indicated that increased SII predicts higher mortality in 120 days follow‐up, and the risk of short‐term mortality in SII > 666.31 × 109/L group is increased 4.671‐fold. Patients with SII > 666.31 × 109/L had higher proportion of male, hypertension, smoking, higher admission NIHSS score, higher systolic blood pressure, and higher proportion of 120 days mortality. Higher SII predicted a worse 120 days mortality was worked out by Kaplan–Meier methods.ConclusionAn elevated SII was remarkably associated with 120 days mortality in severe stenosis ICA‐AIS and SAP patients.
Surface‐Based Morphometry Analysis of the Cerebral Cortex in Patients With Probable Idiopathic Rapid Eye Movement Sleep Behavior Disorder
Authors: Najafzadeh Milad , Saeeidian‐Mehr Athareh , Akbari‐Lalimi Hossein , Ganji Zohre , Nasseri Shahrokh , Zare Hoda , Ferini‐Strambi Luigi 
Published: September 2024

ABSTRACTIntroductionStrong indications support the notion that idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) acts as a precursor to multiple α‐synucleinopathies, including Parkinson's disease and dementia with Lewy bodies. Despite numerous investigations into the alterations in cortical thickness and the volume of subcortical areas associated with this condition, comprehensive studies on the cortical surface morphology, focusing on gyrification and sulcal depth changes, are scarce. The purpose of this research was to explore the cortical surface morphology in individuals with probable iRBD (piRBD), to pinpoint early‐phase diagnostic markers.MethodsThis study included 30 piRBD patients confirmed using the RBD Screening Questionnaire (RBDSQ) and 33 control individuals selected from the Parkinson's Progression Markers Initiative (PPMI) database. They underwent neurophysiological tests and MRI scans. The FreeSurfer software was utilized to estimate cortical thickness (CTH), cortical and subcortical volumetry, local gyrification index (LGI), and sulcus depth (SD). Subsequently, these parameters were compared between the two groups. Additionally, linear correlation analysis was employed to estimate the relationship between brain morphological parameters and clinical parameters.ResultsCompared to the healthy control (HC), piRBD patients exhibited a significant reduction in CTH, LGI, and cortical volume in the bilateral superior parietal, lateral occipital, orbitofrontal, temporo‐occipital, bilateral rostral middle frontal, inferior parietal, and precentral brain regions. Moreover, a significant and notable correlation was observed between CTH and Geriatric Depression Scale (GDS), letter–number sequencing (LTNS), the Benton Judgment of Line Orientation (BJLO) test, and the symbol digit modalities test (SDMT) in several brain regions encompassing the motor cortex.ConclusionPatients with piRBD displayed widespread atrophy in various brain regions, predominantly covering the motor and sensory cortex. Furthermore, LGI could serve as a prognostic biomarker of disease's progression in piRBD.
The Monocyte‐to‐Lymphocyte Ratio Was Associated With Intraplaque Neovascularization of the Carotid Artery on AngioPLUS
Authors: Zhai Mingfeng , Sun Xiao , Wang Jian , Xu Jimei , Bian Fuqin , Wu Menglin , Yang Yafei , Chen Hongwei , Lu Jinghong 
Published: September 2024

ABSTRACTBackgroundThe monocyte–lymphocyte ratio (MLR) is a hematological test parameter that reflects the status of both monocytes and lymphocytes as inflammatory cells. This study aims to investigate the relationship between MLR and carotid intraplaque neovascularization (IPN) in patients with asymptomatic carotid stenosis.MethodsWe performed the Angio Planewave Ultrasensitive (AngioPLUS) screening for patients with carotid plaques. The carotid plaque stability was evaluated by semiquantitative visual grading of carotid IPN. Binary logistic regression models were performed to determine the associations between different clinical and laboratory indicators and the presence of high IPN.ResultsA total of 160 patients were eventually enrolled with 99 in the low IPN group (Scores 0–1) and 61 in the high IPN group (Score 2). Univariate logistic regression showed that age, monocytes, lymphocytes, glycated hemoglobin (HbA1c), fibrinogen, d‐dimmer, and MLR were significantly associated with the presence of high IPN (all p < 0.05). Multivariate logistic regression models showed that MLR was significantly associated with the presence of high IPN after adjusting for other covariates. An MLR value of 32.9 was the optimal cutoff value to differentiate high and low IPN. High MLR was also significantly correlated with the presence of high IPN (odds ratio [OR] = 4.08, 95% confidence interval [CI]: 1.69–9.88, p = 0.002) when included in the above multivariate logistic regression model.ConclusionElevated MLR is closely associated with the presence of high IPN and may serve as a surrogate biomarker for carotid IPN.