bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone lysine crotonylation during acute kidney injury in mice
Authors: Ruiz-Andres Olga , Sanchez-Niño Maria Dolores , Cannata-Ortiz Pablo , Ruiz-Ortega Marta , Egido Jesus , Ortiz Alberto , Sanz Ana Belen 
Published: April 2016

ABSTRACT
Acute kidney injury (AKI) is a potentially lethal condition for which no therapy is available beyond replacement of renal function. Post-translational histone modifications modulate gene expression and kidney injury. Histone crotonylation is a recently described post-translational modification. We hypothesized that histone crotonylation might modulate kidney injury. Histone crotonylation was studied in cultured murine proximal tubular cells and in kidneys from mice with AKI induced by folic acid or cisplatin. Histone lysine crotonylation was observed in tubular cells from healthy murine and human kidney tissue. Kidney tissue histone crotonylation increased during AKI. This was reproduced by exposure to the protein TWEAK in cultured tubular cells. Specifically, ChIP-seq revealed enrichment of histone crotonylation at the genes encoding the mitochondrial biogenesis regulator PGC-1α and the sirtuin-3 decrotonylase in both TWEAK-stimulated tubular cells and in AKI kidney tissue. To assess the role of crotonylation in kidney injury, crotonate was used to increase histone crotonylation in cultured tubular cells or in the kidneys in vivo. Crotonate increased the expression of PGC-1α and sirtuin-3, and decreased CCL2 expression in cultured tubular cells and healthy kidneys. Systemic crotonate administration protected from experimental AKI, preventing the decrease in renal function and in kidney PGC-1α and sirtuin-3 levels as well as the increase in CCL2 expression. For the first time, we have identified factors such as cell stress and crotonate availability that increase histone crotonylation in vivo. Overall, increasing histone crotonylation might have a beneficial effect on AKI. This is the first observation of the in vivo potential of the therapeutic manipulation of histone crotonylation in a disease state.
Development History of State and Non-State Higher Education Institutions in Russia
Authors: Лосева  , Loseva N. , Петрова  , Petrova N. 
Published: April 2016

Th e article discusses the history of the development of higher education institutions in Russia, public and private
schools, institutions, universities, socio-economic conditions of their creation and development, industry focus, the need
to operate in public education, education and culture.
Return Smoothing, Liquidity Costs, and Investor Flows: Evidence from a Separate Account Platform
Authors: Cao Charles , Farnsworth Grant , Liang Bing , Lo Andrew W. 
Published: April 2016

We use a new hedge fund data set from a separate account platform to examine (1) how much of hedge fund return smoothing is due to main fund–specific factors, such as managerial reporting discretion and (2) the costs of removing hedge fund share restrictions. These accounts trade pari passu with matching hedge funds but feature third-party reporting and permissive share restrictions. We use these properties to estimate that 33% of reported smoothing is due to managerial reporting methods. The platform’s fund-level liquidity is associated with a 1.7% performance reduction on an annual basis. Investor flows chase monthly past performance on the platform but not in the associated funds. This paper was accepted by Neng Wang, finance.
Steering tjanpi in the digital desert
Authors: Williams Robyn 
Published: April 2016

Abstract
Tjanpi fibre-weaving is an innovative and performative art form, connected within the discourse that is contemporary Aboriginal art. Winning the 22nd National Aboriginal & Torres Strait Islander Art Award in 2005 for their large, woven ‘Tjanpi Grass Toyota’ positioned Papulankutja artists as experimental and creative with a distinct and quirky style. This article explores the relevance of cars in the Western Desert community of Papulankutja, which underpins the artists’ ideas and values behind designing the artwork. It also advances new ideas and techniques within Indigenous art in the areas of fibre arts and sculpture. By presenting cars in contemporary art as an example of the engagement in the culture and consumption of material objects, and by comparing Papulankutja’s ‘Tjanpi Grass Toyota’ with other recent examples of cars in contemporary art, I will illustrate how its successful entry in the contemporary art field positions it as innovative and creative, investing in new forms, genres and materials, and acting as an agent of transformation. In Papulankutja, cars, and in particular Toyotas, are not simply utilitarian vehicles but are inscribed in the social fabric of the community as symbolic meaning, and where the status of car ownership is highly sought.
The Dark Knight Rises: Christianity, capitalism and psychopathology
Authors: Popescu Stefan Octavian 
Published: April 2016

Abstract
Through a close reading and analysis of the narrative and visual language used in Nolan’s Batman trilogy, this article deconstructs the subtextual narrative of Christopher Nolan’s Batman trilogy, teasing out the themes of Christianity, psychopathology and capitalism. Furthermore, by investigating theories of capitalism, Christianity and psychopathology, this article elucidates the manner in which these seemingly mutually exclusive ideologies are reconciled in a post-9/11 contemporary culture. By perpetuating to the grand narrative of ‘Terrorism’, The Dark Knight Rises (Nolan, 2012), as a mode of popular cultural production, promotes a fear of difference and of social transgression. The Dark Knight Rises situates the corporation as angelic and the citizen as demon/terrorist and promotes this rhetoric to ensure our dependency on a capitalist system.
Variegated Qissa: (Divided) landscape of (multiple) longings
Authors: Mukherjee Madhuja 
Published: April 2016

Abstract
This short, reflective article explores the settings of Qissa (Singh, 2013), written by the director and the author. By framing the plot in a fable-like spiral narrative mode, the aim of Qissa was to look back at (and beyond) post-partition narratives. By referring to the original screenplay and shooting-stills, this article draws attention to the ways in which ambivalent spaces are produced, and illustrates the ‘to-ing and fro-ing between specific geographical locales and human imagination’. Indeed, if Laura Marks writing about the haptic (and multi-sensory experience) has argued about ‘intercultural’ cinema with reference to diaspora encounters, I revisit Qissa in relation to Gurvinder Singh’s Anhey Ghorey Da Daan (2011) to (re)consider in what way Anup Singh’s film fashions new cinematic terrains, and re-presents Punjab through extensive location shooting.
The Association of Four Polymorphisms within the Insulin-Like Growth Factor 1 Receptor Gene with Milk Production Traits in Simmental Cows
Authors: Szewczuk Małgorzata 
Published: April 2016

Abstract
The aim of this study was to determine the frequency of alleles and genotypes of four polymorphisms located in exons 2, 10 and 16 of the gene encoding insulin-like growth factor type 1 receptor (IGF1R) in the tested herd of 242 Simmental cows and to search for the relationship between these polymorphisms and selected milk production traits. The study applied the following methods: PCR-RFLP and combination of nested PCR and ACRS-PCR. The presence of three genotypes was found for all SNPs. The frequency of alleles was as follows: C - 0.29 and T - 0.71 (IGF1R/e2/MspI), A - 0.33 and G - 0.67 (IGF1R/e2/TaqI), C - 0.77 and T - 0.23 (IGF1R/e10/MspI) and C - 0.53 and T - 0.47 (IGF1R/e16/RsaI). In all lactations, cows with TT (IGF1R/e2/MspI) and GG genotypes (IGF1R/e2/TaqI) produced the highest amounts of milk, fat and protein (P≤0.01), particularly individuals with the combined TT/GG genotypes. As regards the IGF1R/e10/MspI and IGF1R/e16/ RsaI genotypes, the highest milk, fat and protein yields were observed in cows with separate and combined CC/CC genotypes, while the lowest in animals with combined TT/TT genotypes. Cumulative analysis of all genotype combinations showed that individuals with a potentially best combination of TT/GG/CC/CC might be characterized by the highest milk yield as well as fat and protein content in milk. Potentially unfavorable combinations (such as CC/AA/TT/TT and similar) have been almost completely eliminated from the herd tested. The IGF1R gene is proposed as a candidate gene for milk traits in cattle.
Detection of mutations in theCYP21A2gene: genotype-phenotype correlation in Slovenian couples with conceiving problems
Authors: Stangler Herodež Š , Fijavž L , Zagradišnik B , Kokalj Vokač N 
Published: April 2016

AbstractThe objective of this study was to compare the CYP 21A2 genetic profiles of couples with unexplained fertility problems (UFP) with genetic profiles of healthy controls (HCs). Furthermore, we analyzed associations between mutations in theCYP21A2gene and various clinical and laboratory parameters. Allele-specific polymerase chain reaction (PCR) was used in 638 probands with UFP and 200 HCs. Statistic analysis with χ2was used to study the association of mutations with infertility. The effect of mutations on particular clinical and laboratory parameters was assessed with the analysis of variance (ANOVA) test. With regard to theCYP21A2gene, 0.6% of probands with UFP and 0.5% of HCs were positive for the c.290-13A/C>G mutation; 0.6% of probands with UFP and 1.5% of HCs were positive for the p.I172N mutation; there were no probands with UFP positive for the p.P30L mutation, whereas 0.5% of HCs were; and 0.2% of probands with UFP and 0.5% of HCs were found to have the p.V281L mutation. We found a significant association between c.290-13A/C>G mutation and the frequency of significant hormone deviations (χ2= 6.997,p= 0.008). Similar association was also observed between the c.29013A/C>G mutation and the frequency of polycystic ovary syndrome (PCOS) (χ2= 16.775,p= 0.000). Our findings indicate that no significant difference in the prevalence of CYP 21A2 mutations can be found in probands with UFP when compared with HCs without infertility history. The results also imply the significant association of the c.290-13A/ C>G mutation in theCYP21A2gene, not only with the frequency of PCOS, but also with the frequency of significant hormone deviations.
The CHEK2 del5395 is a founder mutation without direct effects for cancer risk in the latvian population
Authors: Plonis J , Kalniete D , Nakazawa-Miklasevica M , Irmejs A , Vjaters E , Gardovskis J , Miklasevics E 
Published: April 2016

Abstract
Our objective was to determine: 1) whether the checkpoint kinase 2 (CHEK2) del5395 (g.27417113-27422508 del, NC_000022.11) is a founder mutation in the Latvian population, 2) if there is an association between CHEK2 del5395 mutation and cancer risk, and 3) and whether the CHEK2 del5395 mutation impacts cancer predisposition in Chernobyl disaster liquidators (the civil and military personnel who were called upon to deal with consequences of the 1986 nuclear disaster) as well as geriatric populations. We recruited 438 breast cancer patients, 568 colorectal cancer patients, 399 ovarian cancer patients, 419 prostate cancer patients, 526 healthy blood donors, 480 Chernobyl disaster liquidators and 444 geriatric cancer-free participants. DNA samples were isolated from blood samples and subjected to multiplex polymerase chain reaction (PCR). The truncation of del5395 was estimated by fragment size of the multiplex PCR.All groups were compared to the healthy blood donors using Fisher’s exact test. All p values were two-sided and the odds ratios (OR) calculated by two-by-two table. In cancer groups, the del5395 mutation was most frequently observed in the ovarian cancer group (1.00%, OR = 1.32). In control groups, the del5395 mutation was most frequent (0.76%) in the healthy donors, which exceeded its frequency in the Chernobyl liquidators group and the geriatric group by 0.01 and 0.08%, respectively. For all groups, the OR appeared to be >1 only in ovarian cancer patients. However, OR rates showed no statistical significance in either cancer or control groups, with the p value fluctuating within the range of 0.39-1.00. The CHEK2 gene del5395 is a founder mutation in the Latvian population, which, however, does not have a direct impact on genetic predisposition toward colorectal, breast, ovarian and prostate cancer.
CYP2D6 allele distribution in Macedonians, Albanians and Romanies in the Republic of Macedonia
Authors: Kuzmanovska M , Dimishkovska M , Maleva Kostovska I , Noveski P , Sukarova Stefanovska E , Plaseska-Karanfilska D 
Published: April 2016

Abstract
Cytochrome P450 2D6 (CYP2D6) is an enzyme of great importance for the metabolism of clinically used drugs. More than 100 variants of the CYP2D6 gene have been identified so far. The aim of this study was to investigate the allele distribution of CYP2D6 gene variants in 100 individuals of each of the Macedonian, Albanian and Romany population, by genotyping using long range polymerase chain reaction (PCR) and a multiplex single base extension method. The most frequent variants and almost equally distributed in the three groups were the fully functional alleles *1 and *2. The most common non functional allele in all groups was *4 that was found in 22.5% of the Albanians. The most common allele with decreased activity was *41 which was found in 23.0% of the Romany ethnic group, in 11.0% of the Macedonians and in 10.5% of the Albanians. Seven percent of the Albanians, 6.0% of the Romani and 4.0% of the Macedonians were poor metabolizers, while 5.0% of the Macedonians, 1.0% of Albanians and 1.0% of the Romanies were ultrarapid metabolizers. We concluded that the CYP2D6 gene locus is highly heterogeneous in these groups and that the prevalence of the CYP2D6 allele variants and genotypes in the Republic of Macedonia is in accordance with that of other European populations.
Degradation rates and products of pure magnesium exposed to different aqueous media under physiological conditions
Authors: Kieke Marc , Feyerabend Frank , Lemaitre Jacques , Behrens Peter , Willumeit-Römer Regine 
Published: April 2016

AbstractAs magnesium and many of its alloys are a promising class of degradable implant materials, a thorough understanding of their degradation under physiological conditions is a key challenge in the field of biomaterial science. In order to increase the predictive power of in vitro studies, it is necessary to imitate the in vivo conditions, track the decomposition process and identify the products that form during the degradation pathway. In this in vitro study, slices of pure magnesium were exposed to Hank’s Balanced Salt Solution (HBSS), Dulbecco’s Modified Eagle Medium (DMEM) and simulated body fluid (SBF), respectively, under cell culture conditions, which included CO
Enzymatic synthesis of hydrophobic compounds integrated with membrane separation
Authors: Noworyta Andrzej , Trusek-Holownia Anna 
Published: April 2016

Abstract
The enzymatic synthesis of a highly hydrophobic product (dipeptide precursor) in which the reaction is accompanied by the mass transfer of the reaction product to the organic phase and the substrates to the water phase is considered. Equations describing both continuous and batch processes are formulated. The range of variability in the operating parameters of such a bioreactor is specified, and the correlations reported in the literature to describe mass transfer in the membrane contactor are validated. The proposed process was verified experimentally, and good agreement between the determined and calculated concentrations was obtained in both phases.
Linarite from the Ag-Pb ore deposit at Kletné near Suchdol nad Odrou (Jeseníky Culm, Vítkov Highlands)
Authors: Hrazdil Vladimír , Houzar Stanislav , Sejkora Jiří , Koníčková Šárka , Jarošová Lenka 
Published: April 2016

Abstract
Linarite, PbCu2+(SO4)(OH)2, and associated minerals were studied at new locality near Kletné, where they occur in dump material of historic Ag-Pb mines exploited during the 16th century. Linarite forms thin blue coatings and tiny dark blue crystals (<1 mm in size) in small cavities, in assemblage with cerussite, brochantite and supergene copper sulfides. Mineral was identified by chemical analyses (electron microprobe), Raman spectroscopy and powder X-ray diffraction analysis. Chemical composition of the studied linarite can be expressed by empirical formula Pb0.98Cu1.06(SO4)Σ0.96(OH)2.15 and its refined unit-cell parameters are: a = 9.6944(3), b = 5.6499(2), c = 4.6846(1) Å, ß = 102.669(3)° and V = 250.50(1) Å3. Linarite formed together with other supergene minerals in the oxidation zone of the deposit by weathering of Pb- and Cu-sulphides.
Campgrounds Suitability Evaluation Using GIS-based Multiple Criteria Decision Analysis: A Case Study of Kuerdening, China
Authors: Cuirong Wang , Zhaoping Yang , Huaxian Liu , Fang Han , Wenjin Xia 
Published: April 2016

AbstractThe main objective of this study was to evaluate the suitability and select the most appropriate areas for building campgrounds in Kuerdening, China. To achieve this aim, AHP and GIS-based weighted overlay methods were adopted. AHP was used to determine the weights of the indexes, and ArcGIS 10 was used to calculate and map the campground suitability. In pursuit of minimum environmental effects and sustainable development, this paper identifies four factors to evaluate the suitability of areas for building campgrounds: natural environment condition, landscape condition, safety condition and infrastructure condition. The final outcome of this studywas the suitability map for building campgrounds. This research not only provides a theoretical guide for the construction of campgrounds in this area but also provides a scientific and efficientworkflow to evaluate the appropriateness of other areas. The result is reasonable and operable for camping facilities development and also useful for managers and planners working in local governments as well as investors.
Challenging Competition with CSR: Going Beyond the Marketing Mix to Make a Difference
Authors: Du Shuili , Sen Sankar 
Published: April 2016

Abstract
Social initiatives that make a difference for the consumers are able to win consumers’ hearts and build close and lasting relationships. A program that offers real participation and goes beyond the standard marketing mix can therefore effectively reshape the competitive game with a market leader. Key consumer/societal problems present unprecedented opportunities for companies to gain long-term competitive advantages by creating both social and business value.
We show how making a noticeable difference in the quality of oral health care of the children in Hispanic immigrant communities helped an American brand gain significant ground in this market. Rather than competing head-to-head against the market leader by making incremental improvements in product attributes or relying on price promotions, the challenging brand resorted to an innovative CSR initiative.
Arab Trade Dynamics after the Implementation of the Pan Arab Free Trade Area (1998–2012)
Authors: Harb Georges , Shady Nora Abou 
Published: April 2016

AbstractWith the entry into force of the Pan Arab Free Trade Area (PAFTA) in 2005, intra-Arab trade became tariff free, completing the trade liberalization process started in 1998. Making use of data covering the 1998–2012 period, we estimate the impact of PAFTA on intra-Arab trade in manufactured goods using a gravity model and applying panel data estimation techniques. Results suggest that PAFTA has increased intra-members’ trade by nearly 20 %. We also examine potential changes in the trends of Arab countries’ imports of manufactured goods from their main providers after the entry into force of PAFTA. In this respect, there is some evidence of an increase in Arab countries’ imports from Asia from 2005 onwards, in relation to the 1998–2004 period.
Transnational Experts, Rooted Careers. Migrant Professionals from Macedonia in Germany
Authors: Aceska Ana 
Published: April 2016

Abstract
This article is based on a study of migrant professionals from Macedonia who are now in Germany. It aims to assess how migrants who practise professions relate to their identities as experts who can sustain (or at least have the opportunity to sustain) relationships linking their places and societies of origin and the places where they have settled, and who can use these links to assist their careers. The results show a particular pattern: simultaneously, these migrant professionals promote their expertise as ‘transnational’, but aim to have careers that are rooted in one place.
Optimal Shrinkage Estimations for the Parameters of Exponential Distribution Based on Record Values
Authors: Zakerzadeh Hojatollah , Jafari Ali Akbar , Karimi Mahdieh 
Published: April 2016

<p>This paper studies shrinkage estimation after the preliminary test for the parameters of exponential distribution based on record values. The optimal value of shrinkage coefficients is also obtained based on the minimax regret criterion. The maximum likelihood, pre-test, and shrinkage estimators are compared using a simulation study. The results to estimate the scale parameter show that the optimal shrinkage estimator is better than the maximum likelihood estimator in all cases, and when the prior guess is near the true value, the pre-test estimator is better than shrinkage estimator. The results to estimate the location parameter show that the optimal shrinkage estimator is better than maximum likelihood estimator when a prior guess is close<br />to the true value. All estimators are illustrated by a numerical example.</p>
Establecimiento in vitro de Hypericum goyanesii Cuatrec. E Hypericum juniperinum Kunth, a partir del cultivo de semillas
Authors: Pérez Martínez Belkys Adriana 
Published: April 2016

<p>Título en ingles: <strong>Establishing <em>in vitro</em> <em>Hypericum goyanesii</em> Cuatrec. E <em>Hypericum juniperinum</em> Kunth, </strong><strong>from seeds culture </strong><strong>Germination <em>in vitro</em> Hypericum</strong></p><p>El propósito de este estudio fue evaluar medios de cultivo de germinación para el establecimiento <em>in vitro</em> de <em>Hypericum goyanesii</em> e <em>Hypericum juniperinum</em> como estrategia de conservación <em>ex situ,</em> por medios biotecnológicos de especies vegetales pertenecientes al ecosistema alto-andino.<em> </em>Las semillas se desinfectaron con hipoclorito de sodio y se sembraron en seis tratamientos basados en los medios de cultivo Murashige &amp; Skoog (MS) y MS con reducción del 50% de sus macro y microsales y vitaminas, con y sin la adición de carbón activado y pulpa de banano. La germinación se favoreció por el empleo de pulpa de banano en el medio MS con reducción de sales y suplementado con carbón activado. Fue posible evidenciar que los explantes sexuales de <em>H. goyanesii</em> e <em>H. juniperinum </em>estuvieron influenciados positivamente en la variable porcentaje de germinación, por el empleo de sustancias orgánicas en reemplazo de reguladores de crecimiento. </p>