bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox‐Neutral Fragment Coupling.
Authors: Nawrat Christopher C. , Jamison Christopher R. , Slutskyy Yuriy , MacMillan David W. C. , Overman Larry E. 
Published: February 2016

AbstractThis method generates alkyl radicals from tertiary alkyl cesium oxalates derived from the corresponding alcohols.
ChemInform Abstract: L‐Proline Derived Arylmethanamine Ligands and Their Application in the Copper‐Catalyzed Asymmetric Henry Reaction: A Rare Example of a Cu‐Complex with a Dicopper Tetraacetate Core.
Authors: Niedziejko Piotr , Szewczyk Magdalena , Kalicki Przemyslaw , Kaluza Zbigniew 
Published: February 2016

AbstractA range of L‐proline derived diamines are synthesized and the 4‐methoxyphenyl derivative (PRD) is employed as optimal ligand for the Cu(II)‐catalyzed Henry reaction of aliphatic and aromatic aldehydes with nitromethane.
ChemInform Abstract: Silica Sulfuric Acid Mediated Acylation of Amines with 1,3‐Diketones via C—C Bond Cleavage under Solvent‐Free Conditions.
Authors: Guo Ruiqiang , Zhu Chuanlei , Sheng Zhe , Li Yanzhe , Yin Wei , Chu Changhu 
Published: February 2016

AbstractWater and molecular oxygen play an important role in the acylation reaction of aromatic amines, whereas alkyl amides are not obtained in the presence of oxygen.
ChemInform Abstract: Gold(I) Catalyzed Sequential Dehydrative Cyclization/Intermolecular [4 + 2] Cycloaddition of Alkynyldienols onto Activated Alkynes/Alkenes: A Facile Route to Substituted Norbornadienes/Norbornenes.
Authors: Uruvakili Anasuyamma , Gangadhararao G. , Kumara Swamy K. C. 
Published: February 2016

AbstractA new one‐pot synthesis of highly substituted norbornadienes/norbornenes via gold‐catalyzed dehydrative cyclization followed by intermolecular[4 + 2] cycloaddition of alkynyldienols and activated alkynes under mild conditions is described.
ChemInform Abstract: Indium(III)‐Catalyzed Reduction of Nitrobenzenes to Anilines: Scope and Limitations
Authors: Sakai Norio , Asama Shun , Konakahara Takeo , Ogiwara Yohei 
Published: February 2016

Abstractusing 1,1,3,3‐tetramethyldisiloxane as selective deoxygenation agent
ChemInform Abstract: Selective Dealkylation of Alkyl Aryl Ethers.
Authors: Zhang Ming‐Xin , Hu Xu‐Hong , Xu Yun‐He , Loh Teck‐Peng 
Published: February 2016

AbstractThe dealkylation of aryl alkyl ethers is achieved by treatment with NaOtBu in DMSO.
ChemInform Abstract: Cu‐Mediated Nitrogen Atom Transfer via CN Bond Cleavage.
Authors: Liu Lixin , Dong Jianyu , Zhang Yaxing , Zhou Yongbo , Yin Shuang‐Feng 
Published: February 2016

AbstractThe first copper promoted aerobic oxidative N‐atom transfer via simultaneous cleavage of the CN triple bond and the C—CN bond of acetonitrile to produce aryl nitriles in high yields is described.
ChemInform Abstract: Copper‐Mediated Stereospecific C—H Oxidative Sulfenylation of Terminal Alkenes with Disulfides.
Authors: Tu Hai‐Yong , Hu Bo‐Lun , Deng Chen‐Liang , Zhang Xing‐Guo 
Published: February 2016

AbstractA variety of terminal alkenes (I) and (IV) undergo oxidative coupling reaction with various diaryl disulfides (II) to afford the corresponding (E)‐vinyl sulfides in moderate to good yields.
ChemInform Abstract: Copper‐Catalyzed Enantioselective 1,6‐Boration of para‐Quinone Methides and Efficient Transformation of gem‐Diarylmethine Boronates to Triarylmethanes.
Authors: Lou Yazhou , Cao Peng , Jia Tao , Zhang Yongling , Wang Min , Liao Jian 
Published: February 2016

AbstractThe first enantioselective copper‐catalyzed 1,6‐conjugate addition of bis(pinacolato)diboron to para‐quinone methides is presented.
ChemInform Abstract: Ethers as Hydrogen Sources in BF3·OEt2 Promoted Reduction of Diphenylmethyl Alcohols, Ethers and Esters to Hydrocarbons.
Authors: Li Jiaqiang , Liu Qing , Shen Hang , Huang Ruofeng , Zhang Xiaohui , Xiong Yan , Chen Changguo 
Published: February 2016

AbstractA series of polyarylalkane derivatives is obtained using a novel ether/BF3OEt2 reductive system.
ChemInform Abstract: LDA‐Mediated Synthesis of Triarylmethanes by Arylation of Diarylmethanes with Fluoroarenes at Room Temperature.
Authors: Ji Xinfei , Huang Tao , Wu Wei , Liang Fang , Cao Song 
Published: February 2016

AbstractVariously substituted diarylmethanes, 9H‐fluorene and 9H‐xanthene are arylated regioselectively with electron‐neutral fluoroarenes or fluoroarenes containing electron withdrawing‐groups.
ChemInform Abstract: Stereoselective, Cascade Synthesis of trans‐Enynones Through Coupling‐Isomerization Reaction.
Authors: Chinta Bhavani Shankar , Baire Beeraiah 
Published: February 2016

AbstractStereoselective cascade synthesis of a broad range of trans‐enynones (III) and (VI) is achieved via CuCl/piperidine promoted coupling‐isomerization reaction.
ChemInform Abstract: Turning Spiroketals Inside Out: A Rearrangement Triggered by an Enol Ether Epoxidation.
Authors: Lorenc Chris , Sauri Josep , Moser Arvin , Buevich Alexei V. , Williams Antony J. , Williamson R. Thomas , Martin Gary E. , Peczuh Mark W. 
Published: February 2016

AbstractAn epoxide opening spirocyclization reaction demonstrated on a novel multicyclic spiroketal starting material is described.
ChemInform Abstract: [4 + 3] Cycloadditions with Bromo‐Substituted Morita—Baylis—Hillman Adducts of Isatins and N‐(ortho‐Chloromethyl)aryl Amides
Authors: Zhan Gu , Shi Ming‐Lin , He Qing , Du Wei , Chen Ying‐Chun 
Published: February 2016

Abstractto give challenging aza‐spirocycloheptane oxindole scaffolds
ChemInform Abstract: Synthesis of Bridged Diketopiperazines by Using the Persistent Radical Effect and a Formal Synthesis of Bicyclomycin.
Authors: Amatov Tynchtyk , Pohl Radek , Cisarova Ivana , Jahn Ullrich 
Published: February 2016

AbstractBy taking advantage of the persistent radical effect, a new approach to bridged diketopiperazines (DKP) with variable ring sizes is developed.
ChemInform Abstract: Hydrazone‐Initiated Carbene/Alkyne Cascades to Form Polycyclic Products: Ring‐Fused Cyclopropenes as Mechanistic Intermediates.
Authors: Le Phong Q. , May Jeremy A. 
Published: February 2016

AbstractA variety of bridged, caged, and fused polycyclic systems is obtained from hydrazones by a cascade reaction sequence involving hydrazone decomposition, dediazotization, cyclopropanation, carbene generation, and C—H bond insertion using NaOTms and a rhodium catalyst.
ChemInform Abstract: Synthesis of Diversely Functionalized 2,2‐Disubstituted Oxetanes: Fragment Motifs in New Chemical Space.
Authors: Davis Owen A. , Croft Rosemary A. , Bull James A. 
Published: February 2016

AbstractStarting from unsymmetrically substituted acceptor‐acceptor or acceptor‐aryl diazo compounds a two‐step transformation via O—H insertion of substituted 2‐haloethanols and subsequent base‐induced cyclization is elaborated.
ChemInform Abstract: A Rapid Entry to Diverse γ‐Ylidenetetronate Derivatives Through Regioselective Bromination of Tetronic Acid Derived γ‐Lactones and Metal‐Catalyzed Postfunctionalization.
Authors: Chopin Nicolas , Yanai Hikaru , Iikawa Shinya , Pilet Guillaume , Bouillon Jean‐Philippe , Medebielle Maurice 
Published: February 2016

AbstractThe synthesis of a series of γ‐ylidenetetronate derivatives is accomplished through a new aldolization/dehydration sequence.
ChemInform Abstract: BICMAP‐Rhodium(I)‐Catalyzed Asymmetric 1,4‐Addition of Arylboronic Acids to Coumarins.
Authors: Mino Takashi , Miura Kazuki , Taguchi Hiroyuki , Watanabe Kohei , Sakamoto Masami 
Published: February 2016

Abstract4‐Arylchroman‐2‐one derivatives are obtained in good yields and with high enantioselectivities.
ChemInform Abstract: Redox‐Triggered α‐C—H Functionalization of Pyrrolidines: Synthesis of Unsymmetrically 2,5‐Disubstituted Pyrrolidines.
Authors: Cheng Yong‐Feng , Rong Hao‐Jie , Yi Cheng‐Bo , Yao Jun‐Jun , Qu Jin 
Published: February 2016

AbstractThe reaction of o‐quinone (I) with pyrrolidine (II) gives the polycyclic N,O‐acetal (III) which can be readily converted to disubstituted pyrrolidines (V) and (VIII).
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of Ensulfonamides/Enamides via Catalyst‐Free Intermolecular Addition of Indoles/Pyrroles/Imidazole to Allenamides.
Authors: Li Honghe , Ma Ting , Li Xiaoxiao , Zhao Zhigang 
Published: February 2016

AbstractEnamides are obtained using acyl instead of tosyl as amino‐protecting group of the allenamides.
ChemInform Abstract: Redox‐Neutral Rhodium‐Catalyzed C—H Functionalization of Arylamine N‐Oxides with Diazo Compounds: Primary C(sp3)—H/C(sp2)—H Activation and Oxygen‐Atom Transfer.
Authors: Zhou Bing , Chen Zhaoqiang , Yang Yaxi , Ai Wen , Tang Huanyu , Wu Yunxiang , Zhu Weiliang , Li Yuanchao 
Published: February 2016

AbstractA novel Rh(III)‐catalyzed regioselective and redox‐neutral annulation reaction of 1‐naphthylamine N‐oxides with α‐diazomalonates is developed.
ChemInform Abstract: Dearomative Indole Bisfunctionalization via a Diastereoselective Palladium‐Catalyzed Arylcyanation.
Authors: Petrone David A. , Yen Andy , Zeidan Nicolas , Lautens Mark 
Published: February 2016

AbstractThe palladium‐catalyzed reaction of (o‐bromobenzoyl)indoles (I) and (VII) with Zn(CN)2 gives rise to a variety of 6‐oxo‐10b,11‐dihydro‐6H‐isoindolo[2,1‐a]indoles (III) and (VIII), resp., with good to high diastereoselectivities.
ChemInform Abstract: An Efficient Route to Ethyl 5‐Alkyl‐ (Aryl)‐1H‐1,2,4‐triazole‐3‐carboxylates.
Authors: Chudinov M. V. , Matveev A. V. , Zhurilo N. I. , Prutkov A. N. , Shvets V. I. 
Published: February 2016

AbstractSeven 5‐substituted 1H‐1,2,4‐triazole‐3‐carboxylates are prepared by cyclization of (III) which can be prepared by the reaction of ethyl thiooxamate (I) but also from ethyl 2‐ethoxy‐2‐iminoacetate hydrochloride with carboxylic acid hydrazides (II).
ChemInform Abstract: Isopropanol and Potassium tert‐Butoxide Promoted Intramolecular Direct sp2 C—H Functionalization: An Expedient Synthesis of 1,2,3‐Triazole Annulated Chromens and Quinolones.
Authors: Mondal Biplab , Roy Brindaban 
Published: February 2016

AbstractA base‐promoted intramolecular sp2 C—H functionalization is developed to synthesize 1,2,3‐triazole annulated chromenes and quinolones from 2‐halophenoxymethyl‐ or 2‐halophenylamido‐substituted 1,2,3‐triazoles.
ChemInform Abstract: A Scalable Synthesis of (R,R)‐2,6‐Dimethyldihydro‐2H‐pyran‐4(3H)‐one.
Authors: Young Ian S. , Haley Matthew W. , Tam Annie , Tymonko Steven A. , Xu Zhongmin , Hanson Ronald L. , Goswami Animesh 
Published: February 2016

AbstractKey step of the improved synthesis of title compound (VIII) is the Kulinkovich cyclopropanation, and subsequent oxidative fragmentation of the cyclopropanol (IV).
ChemInform Abstract: Recyclable Poly‐Zn3(OAc)4—3,3′‐Bis(aminoimino)binaphthoxide Catalyst for Asymmetric Iodolactonization.
Authors: Arai Takayoshi , Kojima Takahiro , Watanabe Ohji , Itoh Tsutomu , Kanoh Hirofumi 
Published: February 2016

AbstractThe catalyst can be easily recovered by addition of mol.
ChemInform Abstract: Palladium‐Catalyzed 6‐endo‐Selective Oxycyclization—Alkene Addition Cascades of ortho‐Alkynylarylcarboxamides and α,β‐Unsaturated Carbonyl Compounds.
Authors: Madich Youssef , Alvarez Rosana , Aurrecoechea Jose M. 
Published: February 2016

AbstractThis cascade reaction does not require protic solvents and needs only substoichiometric amounts of KI additive.
ChemInform Abstract: Practical Pd(II)‐Catalyzed C—H Alkylation with Epoxides: One‐Step Syntheses of 3,4‐Dihydroisocoumarins.
Authors: Cheng Guolin , Li Tuan‐Jie , Yu Jin‐Quan 
Published: February 2016

AbstractBenzoic acid derivatives equipped with various functional groups are transformed in a scalable manner with a diverse range of 1‐substituted as well as 1,1‐ and 1,2‐disubstituted epoxides to form 3,4‐dihydroisocoumarins in moderate to often high yields.
ChemInform Abstract: A Magnesium‐Based Diastereoselective Preparation of Pyridylic 1,3‐Amino Alcohols Using the tert‐Butyl Sulfinamide Auxiliary.
Authors: Fjelbye Kasper , Svenstrup Niels , Pueschl Ask 
Published: February 2016

AbstractThe title amino alcohols are obtained in two steps starting from pyridylic halides.
ChemInform Abstract: Platinum(II) Schiff Base Complexes as Photocatalysts for Visible‐Light‐Induced Cross‐Dehydrogenative Coupling Reactions.
Authors: Shelar Deepak Prakash , Li Ting‐Ting , Chen Yong , Fu Wen‐Fu 
Published: February 2016

AbstractFour platinum(II) schiff base complexes are synthesized and one of them is examined in the visible‐light‐induced coupling reactions of tetrahydroisoquinolines (I) with different nucleophiles.
ChemInform Abstract: Switchable Selectivity in an NHC‐Catalyzed Dearomatizing Annulation Reaction.
Authors: Guo Chang , Fleige Mirco , Janssen‐Mueller Daniel , Daniliuc Constantin G. , Glorius Frank 
Published: February 2016

AbstractA novel N‐heterocyclic carbene‐catalyzed regiodivergent annulation reaction of N‐iminoisoquinolinium ylides with enals is studied.
ChemInform Abstract: A Novel Protocol for the Facile Construction of Tetrahydroquinoline Fused Tricyclic Frameworks via an Intramolecular 1,3‐Dipolar Nitrile Oxide Cycloaddition Reaction.
Authors: Bakthadoss Manickam , Vinayagam Varathan 
Published: February 2016

AbstractThe successful development of an efficient method for the construction of fused tricyclic tetrahydroisoxazoloquinoline scaffolds involving an intramolecular 1,3‐dipolar nitrile oxide cycloaddition reaction utilizing Baylis—Hillman derivatives in good yields is achieved for the first time.
ChemInform Abstract: Two‐Component Domino Reactions Initiated from Ketenes: Serendipitous Synthesis of Quinolizidinones Analogous to Chelated Lobeline′s Conformation.
Authors: Drege Emmanuelle , Venot Pierre‐Etienne , Le Bideau Franck , Retailleau Pascal , Joseph Delphine 
Published: February 2016

AbstractA highly diastereoselective one‐pot procedure for the quinolizidinone synthesis from norlobelanine is described.
ChemInform Abstract: Preparation of 2,3‐Disubstituted 5‐Bromo‐1H‐pyrrolo[2,3‐b]pyridine Framework by Fischer Cyclization.
Authors: Alekseyev Roman S. , Amirova Sabina R. , Terenin Vladimir I. 
Published: February 2016

AbstractThe simple and cheap synthesis is general for different alkyl or aryl ketones, but it is not suitable for methyl ketones and N‐substituted piperidin‐4‐ones.
ChemInform Abstract: Synthesis of 2‐Arylpyrazolo[1,5‐a]pyridines by Suzuki—Miyaura Cross‐Coupling Reaction.
Authors: Umei Kentaro , Nishigaya Yosuke , Kamiya Megumi , Kohno Yasushi , Seto Shigeki 
Published: February 2016

AbstractThe title pyridines are obtained by convenient reaction of pyridine triflates with various aryl boronic acids.
ChemInform Abstract: Polyethylene Glycol‐Bonded 1,8‐Diazabicyclo[5.4.0]undec‐7‐ene (PEG—DBU) as a Surfactant‐Combined Base Catalyst for the Application of Nucleosides as Reagents in Multi‐Component Syntheses of 8‐Substituted Pyrido[2,3‐d]pyrimidine‐6‐carbonitriles in Water.
Authors: Shekouhy Mohsen , Khalafi‐Nezhad Ali 
Published: February 2016

AbstractPolyethylene glycol‐bonded 1,8‐diazabicyclo[5.4.0]‐undec‐7‐ene is prepared as a reusable surfactant‐combined basic catalyst and successfully applied for the one‐pot multicomponent synthesis of some novel 8‐substituted pyrido[2,3‐d]pyrimidine carbonitriles in water using nucleosides as starting materials.
ChemInform Abstract: A Strategy for the Triarylation of Pyrrolopyrimidines by Using Microwave‐Promoted Cross‐Coupling Reactions.
Authors: Prieur Vanessa , Pujol M. Dolors , Guillaumet Gerald 
Published: February 2016

AbstractAn efficient strategy for the synthesis of 2,4,6‐triarylated pyrrole[2,3‐d]pyrimidines is described.
ChemInform Abstract: One‐Step Synthesis of 2‐Chloropyrimidin‐4‐ol Derivatives: An Unusual Reactivity of Thiophosgene.
Authors: Callingham Michael , Blum Francesca , Pave Gregoire 
Published: February 2016

AbstractThe reaction of 2‐aminobenzamides (IV) with thiophosgene leads to 2‐chloropyrimidin‐4‐ol derivatives, which are converted without purification into 2‐morpholine derivatives (VI).
ChemInform Abstract: Domino Synthesis of Fused Pyrazolo[5,1‐b]quinazolin‐9(1H)‐ones Catalyzed by CuI via Subsequent Michael Addition and Elimination.
Authors: Zhang Yan , Xu Jing , Li Chao , Wang Xiang‐Shan 
Published: February 2016

AbstractThe reactions of various aminobenzohydrazides with bromocinnamaldehydes afford the unexpected title quinazolinones in one‐pot under mild reaction conditions.
ChemInform Abstract: Regioselective Syntheses of 1,2‐Benzothiazines by Rhodium‐Catalyzed Annulation Reactions.
Authors: Cheng Ying , Bolm Carsten 
Published: February 2016

AbstractA Rh‐catalyzed domino C—H activation/cyclization/condensation sequence is developed to synthesize 1,2‐benzothiazines from NH‐sulfoximes and 2‐diazo‐1,3‐dicarbonyl compounds.
ChemInform Abstract: Asymmetric Synthesis of Emericellamide B.
Authors: Ren Rong‐Guo , Ma Jing‐Yi , Mao Zhuo‐Ya , Liu Yi‐Wen , Wei Bang‐Guo 
Published: February 2016

AbstractThe title compound is prepared in a sequence of 17 linear steps and 9.4% overall yield.
ChemInform Abstract: A Solvent‐Free Facile Synthesis of (E)‐Bis(phosphonium)ethylenes from Organo‐Phosphines and TfOCH2CF2H Reagent.
Authors: Wang Shi‐Meng , Han Jia‐Bin , Zhang Cheng‐Pan , Qin Hua‐Li 
Published: February 2016

AbstractThe temperature and the substituents on the phenyl ring significantly influence the reaction.
ChemInform Abstract: Phosphine‐Catalyzed Addition of P(O)—H Compounds to Ethyl Phenylpropiolate.
Authors: Salin Alexey V. , Il'in Anton V. , Shamsutdinova Fanuza G. , Fatkhutdinov Albert R. , Galkin Vladimir I. , Islamov Daut R. , Kataeva Olga N. 
Published: February 2016

AbstractThe optimized reaction conditions allow the regio‐ and stereoselective synthesis of alkenyl phosphonates.
ChemInform Abstract: Sesquiterpenes from Rhizomes of Cyperus rotundus with Cytotoxic Activities on Human Cancer Cells in vitro.
Authors: Ryu Byeol , Kim Hye Mi , Lee Jae‐Seung , Cho Yoon Jin , Oh Myung Sook , Choi Jung‐Hye , Jang Dae Sik 
Published: February 2016

Abstractisolation, structure elucidation and cytotoxic activities of two new sesquiterpenes, cyperusol A3 (I) and 3β‐hydroxycyperenoic acid (II), together with three already known sesquiterpenes
ChemInform Abstract: A Novel Alkaloid from Aspidosperma pyricollum (Apocynaceae) and Complete 1H and 13C Chemical Shift Assignments
Authors: do Carmo Hadria M. , Braz‐Filho Raimundo , Vieira Ivo J. Curcino 
Published: February 2016

Abstractisolation and characterization of novel indole alkaloid (I) named rel‐pyricolluminol
ChemInform Abstract: Nanocrystalline Iron Oxide Based Electroactive Materials in Lithium Ion Batteries: The Critical Role of Crystallite Size, Morphology, and Electrode Heterostructure on Battery Relevant Electrochemistry
Authors: Bruck Andrea M. , Cama Christina A. , Gannett Cara N. , Marschilok Amy C. , Takeuchi Esther S. , Takeuchi Kenneth J. 
Published: February 2016

AbstractReview: 96 refs.
ChemInform Abstract: Corrin Syntheses. Part 5. Preparation of Metal‐Free Corrin Derivatives via (A→B) Ring Closure. Complexation of the Corrin Chromophore with Metal Ions, and Some Properties of the Ligands in Corrin Complexes
Authors: Blaser Hans‐Ulrich , Winnacker Ernst‐Ludwig , Fischli Albert , Hardegger Bruno , Bormann Dieter , Hashimoto Naoto , Schossig Juergen , Keese Reinhart , Eschenmoser Albert 
Published: February 2016

AbstractReview: [60 refs.
ChemInform Abstract: Transition Metal‐Free Direct C—H (Hetero)arylation of Heteroarenes: A Sustainable Methodology to Access (Hetero)aryl‐Substituted Heteroarenes
Authors: Rossi Renzo , Lessi Marco , Manzini Chiara , Marianetti Giulia , Bellina Fabio 
Published: February 2016

AbstractReview: [99 refs.
ChemInform Abstract: Novel Approaches to Pharmacology‐Oriented and Energy Rich Organic Nitrogen—Oxygen Systems
Authors: Zlotin Sergei G. , Churakov Aleksandr M. , Luk'yanov Oleg A. , Makhova Nina N. , Sukhorukov Alexey Yu. , Tartakovsky Vladimir A. 
Published: February 2016

AbstractReview: [79 refs.
Interhemispheric connections between the infralimbic and entorhinal cortices: The endopiriform nucleus has limbic connections that parallel the sensory and motor connections of the claustrum
Authors: Watson Glenn D.R. , Smith Jared B. , Alloway Kevin D. 
Published: February 2016

ABSTRACTWe have previously shown that the claustrum is part of an interhemispheric circuit that interconnects somesthetic–motor and visual–motor cortical regions. The role of the claustrum in processing limbic information, however, is poorly understood. Some evidence suggests that the dorsal endopiriform nucleus (DEn), which lies immediately ventral to the claustrum, has connections with limbic cortical areas and should be considered part of a claustrum–DEn complex. To determine whether DEn has similar patterns of cortical connections as the claustrum, we used anterograde and retrograde tracing techniques to elucidate the connectivity of DEn. Following injections of retrograde tracers into DEn, labeled neurons appeared bilaterally in the infralimbic (IL) cortex and ipsilaterally in the entorhinal and piriform cortices. Anterograde tracer injections in DEn revealed labeled terminals in the same cortical regions, but only in the ipsilateral hemisphere. These tracer injections also revealed extensive longitudinal projections throughout the rostrocaudal extent of the nucleus. Dual retrograde tracer injections into IL and lateral entorhinal cortex (LEnt) revealed intermingling of labeled neurons in ipsilateral DEn, including many double‐labeled neurons. In other experiments, anterograde and retrograde tracers were separately injected into IL of each hemisphere of the same animal. This revealed an interhemispheric circuit in which IL projects bilaterally to DEn, with the densest terminal labeling appearing in the contralateral hemisphere around retrogradely labeled neurons that project to IL in that hemisphere. By showing that DEn and claustrum have parallel sets of connections, these results suggest that DEn and claustrum perform similar functions in processing limbic and sensorimotor information, respectively. J. Comp. Neurol. 525:1363–1380, 2017. © 2016 Wiley Periodicals, Inc.
Ascending Single‐Dose, Double‐Blind, Placebo‐Controlled Safety Study of Noribogaine in Opioid‐Dependent Patients
Authors: Glue Paul , Cape Gavin , Tunnicliff Donna , Lockhart Michelle , Lam Fred , Hung Noelyn , Hung C. Tak , Harland Sarah , Devane Jane , Crockett R. S. , Howes John , Darpo Borje , Zhou Meijian , Weis Holger , Friedhoff Lawrence 
Published: February 2016

AbstractIbogaine is a psychoactive substance that may reduce opioid withdrawal symptoms. This was the first clinical trial of noribogaine, ibogaine's active metabolite, in patients established on methadone opioid substitution therapy (OST). In this randomized, double‐blind, placebo‐controlled single ascending‐dose study, we evaluated the safety, tolerability, and pharmacokinetics of noribogaine in 27 patients seeking to discontinue methadone OST who had been switched to morphine during the previous week. Noribogaine doses were 60, 120, or 180 mg (n = 6/dose level) or matching placebo (n = 3/dose level). Noribogaine was well tolerated. The most frequent treatment‐emergent adverse events were noneuphoric changes in light perception ∼1 hour postdose, headache, and nausea. Noribogaine had dose‐linear increases for AUC and Cmax and was slowly eliminated (mean t1/2 range, 24–30 hours). There was a concentration‐dependent increase in QTcI (0.17 ms/ng/mL), with the largest observed mean effect of ∼16, 28, and 42 milliseconds in the 60‐, 120‐, and 180‐mg groups, respectively. Noribogaine showed a nonstatistically significant trend toward decreased total score in opioid withdrawal ratings, most notably at the 120‐mg dose; however, the study design may have confounded evaluations of time to resumption of OST. Future exposure‐controlled multiple‐dose noribogaine studies are planned that will address these safety and design issues.