bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using ELISA to detect pathogen antibodies in wild mammal carcasses: a systematic literature review
Authors: Ruy P.‐É. , McDevitt A. , O'Connor I. , O'Dwyer K. 
Published: October 2024

Abstract

Carcasses of wild mammals provide convenient samples for wildlife disease investigators. Specifically, antibodies can persist in the blood and tissues of animals up to a few days after death and can provide information on exposure to specific pathogens, including microorganisms with zoonotic implications, such as Toxoplasma gondii, Trichinella spp., Brucella spp., and Mycobacterium spp.

Although screening samples from decaying wildlife for antibodies is not a new method, an overview of the literature with clear recommendations on best practices is lacking.

Here, we present results from a systematic review of 115 studies using enzyme‐linked immunosorbent assay (ELISA) to detect pathogen antibodies in wild mammals across 298 individual research projects. We discuss the range of mammalian hosts and the pathogens most represented in the literature and suggest improvements to consider when using samples from decaying animals for seroinvestigation.

Our results indicate that the most examined mammals were artiodactyl ungulates and that antibodies against the bacteria Brucella spp. are those most examined to date, followed by the protozoan Toxoplasma gondii, malignant catarrhal fever virus, Schmallenberg orthobunyavirus, and the coccidian Neospora caninum.

The effect of haemolysis in serum samples on ELISA results was considered in only 3.7% of the research projects we reviewed, sample size decisions were not outlined in 83% of research projects, and half of the projects did not examine seroprevalence in different age classes. Nevertheless, these details are important for replicability and accurate interpretation of results.

We highlight the benefits and limitations of detecting antibodies against pathogens in carcasses from wild mammalian groups. Wild mammals are reservoirs for a wide range of pathogens including those with zoonotic potential and investigating their carcasses can help wildlife investigators to better understand the epidemiology of many diseases with implications for wildlife, livestock, and human health.
‘Dancing with emotions’: An Interpretive Descriptive study of facilitators recognition and response to students' emotions during simulation
Authors: Behrens Claudia C. , Dolmans Diana H. , Driessen Erik W. , Gormley Gerard J. 
Published: October 2024

AbstractIntroductionImmersive simulations can evoke a range of emotions in students. However, little is known about how facilitators recognise and respond to students' emotions during simulations. This study aims to understand how simulation facilitators perceive and respond to students' emotions during simulation—in order to optimise learning.MethodsWe conducted semi‐structured interviews with 10 simulation facilitators who had varying experiences in simulation‐based practice. We explored their experiences of students' emotions in simulations and reactions to these perceived emotional states. Applying an Interpretive Descriptive methodology, drawing upon control‐value theory, we iteratively and reflexively developed themes to address our research question. Based on a contrasting analysis, we used the concept of ‘crafted stories’ to represent our findings.ResultsWe identified three recurring issues and crafted these into stories: (1) facilitators that recognise emotions and adjust the complexity of the simulation in order to dampen intense negative emotions and ‘preserve learning’; (2) those that recognise mainly negative emotions and argue that it is better to let them feel the ‘heat’ in order to prepare them for the realities of clinical practice; (3) those that recognise both negative and positive emotions but let the simulation run as planned for all learners and attend to emotional responses during debriefing.ConclusionSimulation facilitators become aware of students' emotional responses through a range of cues. While some facilitators continually move and react to students' emotions, others intentionally hold back from attempting to alter students' emotional responses. Facilitators' beliefs about how to optimise learning mediate how they react to students' emotional states. Beliefs about learning are predominantly shaped by their experiences in both teaching and real‐world clinical practice. By understanding the delicate balancing act of students' emotional states and altering the complexity of a simulation, we have the opportunity to inform facilitator training in order to enhance learning.
Cover Image
Authors: Jamal Sara Z. , Dieckmann Blake W. , McCollum Gary W. , Penn John S. , Jayagopal Ashwath , Imam Uddin MD 
Published: October 2024

The cover image is based on the Article Imaging Hypoxia to Predict Primary Neuronal Cell Damage in Branch Retinal Artery Occlusion by Sara Z. Jamal et al., https://doi.org/10.1111/micc.12883. Created with BioRender.com.
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What influences interruption of continuous renal replacement therapy in intensive care unit patients: A review with meta‐analysis on outcome variables
Authors: Xiaomei Xia , Yuliang Chong , Jianhong Qiao , Moreira Paulo , Xiujuan Xue 
Published: October 2024

AbstractBackgroundEvidence suggests that 8%–10% of ICU patients receive renal replacement therapy. However, there is a high rate of unplanned CRRT interruption, ranging between 17% and 74%. Studies on unplanned interruption of CRRT mainly focused on the retrospective investigation of related risk factors and conclusions have been diverse.AimsThis article aims to clarify the main influencing factors related to unplanned interruption of continuous renal replacement therapy (CRRT) in adult patients in intensive care units (ICUs).Study DesignA literature review and meta‐analysis were undertaken. Following the application of the Newcastle–Ottawa Scale (NOS), a total of 15 articles were included in a total of 2132 patients who underwent 3690 CRRT procedures and 2181 unplanned interruption times. The methodological guideline of a scoping review was applied for the evidence synthesis while applying the meta‐analysis quantitative methodological guideline to identify and clarify main influencing factors related to unplanned interruption of CRRT. The reporting Prisma Protocol was followed.ResultsLonger filter life and prothrombin activation time, higher red blood cell count, greater transmembrane pressure, faster blood flow rate, intermittent saline irrigation, lower creatinine level, low prothrombin activity and pre‐dilution are factors identified to potentially affect unplanned CRRT in ICU patients.ConclusionsAvailable evidence suggests four clinical challenges associated with unplanned CRRT interruption, namely: (a) effects of red blood cell count, filter life, cross‐mode pressure, blood flow velocity, prothrombin activity and activated partial thrombin time on unplanned interruption; (b) influence of dilution mode on unplanned interruption; (c) influence of intermittent saline irrigation on unplanned interruption; (d) influence of Scr level on unplanned interruption.Relevance to Clinical PracticeThe potential to increase the ability to better manage unplanned CRRT in ICUs has been identified in this article and constitutes a relevant potential health care management contribution that can be implemented by nurses.
Dysregulation of T cell response in the pathogenesis of inflammatory bowel disease
Authors: Chandwaskar Rucha , Dalal Rajdeep , Gupta Saurabh , Sharma Aishwarya , Parashar Deepak , Kashyap Vivek K. , Sohal Jagdip Singh , Tripathi Subhash K. 
Published: October 2024

AbstractInflammatory bowel disease (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are gut inflammatory diseases that were earlier prevalent in the Western Hemisphere but now are on the rise in the East, with India standing second highest in the incidence rate in the world. Inflammation in IBD is a cause of dysregulated immune response, wherein helper T (Th) cell subsets and their cytokines play a major role in the pathogenesis of IBD. In addition, gut microbiota, environmental factors such as dietary factors and host genetics influence the outcome and severity of IBD. Dysregulation between effector and regulatory T cells drives gut inflammation, as effector T cells like Th1, Th17 and Th9 subsets Th cell lineages were found to be increased in IBD patients. In this review, we attempted to discuss the role of different Th cell subsets together with other T cells like CD8+ T cells, NKT and γδT cells in the outcome of gut inflammation in IBD. We also highlighted the potential therapeutic candidates for IBD.
Cosmopolitan gastro‐aesthetics and the new tastes of Timor
Authors: Tusinski Gabriel 
Published: October 2024

AbstractIn Dili, a new generation of Timorese “foodies” are reshaping the culinary landscape by formulating “Timorese Cuisine.” Armed with mobile devices and active on social media, they seek to build Timor's reputation as a tourist destination by managing consumers' appreciation for “local foods” through a novel “gastro‐aesthetics” a culturally inflected field of qualities which contribute to judgements of the “pleasantness,” “beauty,” or “goodness” of food. But bringing Timorese foodways into correspondence with global consumer tastes unsettles their qualitative characteristics and their medical, moral, and cosmological meanings. With cultural politics dominated by resistance heroes and the Indonesian‐educated “new generation,” this movement marks a youthful contribution to Timor‐Leste's viability through entrepreneurialism. As the country's fossil fuel economy is challenged by climate change, and tourism promoted as a sustainable alternative, configuring “Timorese Cuisine” is an element of nation‐branding at once elevates and diminishes the efficacies of “local foods” as social substances.
Radiation therapy communication: Retreatment of multiple histologically confirmed oligodendroglioma drop metastasis with stereotactic radiotherapy in a dog
Authors: Rancilio Nicholas J , Murakami Keiko , Harm Tyler , Christensen Neil 
Published: October 2024

AbstractA 10‐year‐old female spayed boxer was treated with stereotactic radiotherapy (SRT) for a suspected glioma in the left piriform lobe. The intra‐axial lesion was T2 hyperintense, T2 FLAIR hyperintense, T1 hypointense, and did not uptake contrast. Imaging was performed with an MRI every 3 months, and at the 6‐month recheck, new lesions in the left hippocampus and right piriform lobe were evident without clinically apparent neurological progression. A second course of SRT was prescribed for the new lesions. Euthanasia was elected 14 months after the first course of SRT, and necropsy confirmed oligodendroglioma with drop metastasis.
Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocol
Authors: Mahdi Omar Ali , Gharios Maria , Fatfat Adnan , El-Hajj Victor Gabriel , Singh Aman , Edström Erik , Elmi-Terander Adrian 
Published: October 2024

IntroductionNerve sheath tumours arise from both the central and peripheral nervous systems. In particular, cases of spinal or paraspinal origins are scarce and poorly covered in the literature. This systematic review aims to summarise the body of evidence regarding spinal nerve sheath tumours and assess its quality, to provide the current knowledge on epidemiology, tumour characteristics, diagnostics, treatment strategies and outcomes.Methods and analysisDatabases including PubMed, Web of Science and Embase will be searched using keywords such as “spinal”, “nerve sheath”, “neurofibroma”, “schwannoma”, “neurinoma” and “neurilemoma”. The search will be limited to studies published no earlier than 2000 without language restrictions. Case reports, editorials, letters and reviews will be excluded. Reference lists of identified studies will be searched to find possible additional relevant records. Identified studies will be screened for inclusion, by one reviewer at first and then two independent ones in the next step to increase the external validity. The Rayyan platform will be used for the screening and inclusion process. Data extraction within several predetermined areas of interest will proceed. Subjects of interest include epidemiology, histopathology, radiological diagnostics, surgery, complications, non-surgical treatment alternatives, disease outcomes and predictors of outcome, and recurrence rates. On satisfactory amount of homogenous data, a meta-analysis of key outcomes such as recurrence risk or postoperative neurological improvement will be performed. This systematic review will primarily serve as a reference guide to aid in diagnosis and treatment of patients with spinal schwannomas, while also spotlighting the knowledge gaps in the literature to help guide future research initiatives.Ethics and disseminationEthics approval is not required for the protocol or review as both are based on existing publications. For dissemination, the final manuscript will be submitted to a peer-reviewed journal.
“Dignifying the Ordinary”: Why, What, and How of Social Practice Theory in Christian Philosophy
Authors: van Putten Robert , Cusveller Bart 
Published: October 2024

Abstract
It seems remarkable that several philosophers in the Reformed tradition have recently interacted with social practice theory without interacting with each other. This gave rise to the question as to whether they interact differently or similarly with social practice theory and to what extent Reformed philosophy might benefit from such an interaction. In this article, therefore, we aim to clear the way by addressing three strands in Reformed philosophy, namely, Nicholas Wolterstorff, the normative practice approach, and James K. A. Smith. We explore why they use social practice theory, what they do with it, and how they make it their own. Finally, we highlight what unites them and what divides them, and conclude with suggestions as to how they might benefit from each other’s work in social practice theory.
Liquidity Preference, Interest Rate Spread, and the Transformation of the US Financial System
Authors: Yoon Yeo Hyub , Neupane Grishma 
Published: October 2024

This article examines empirical patterns of interest rate spreads between yields on long-term corporate bonds and the Federal Funds Rate (FFR) in the United States over the period from 1960 through 2023. Since the early 1980s, discernible patterns of interest spreads have emerged, revealing marked deviations in corporate bond yields from the FFR. We focus on financial market forces particularly arising from financial intermediaries in analyzing these patterns. To this end, the article develops a theoretical framework based on the concept of liquidity preference in Keynes’s 1937 papers and the works of Hyman Minsky and Victoria Chick. We also conduct cointegration analyses for corporate bond yields, the FFR, and financial intermediaries’ leverage ratios. Overall, our empirical results indicate that the relationship between the FFR and corporate bond yields—particularly with respect to their long-run relationship and interest rate markups—has markedly changed since the 1980s and is significantly affected by financial intermediaries’ asset/capital leverage ratios. As a policy implication, regulatory reforms aimed at enhancing the Federal Reserve Bank’s capacity to steer long-term rates and contain intermediaries’ balance sheet leverage, particularly those centered on risky asset trading to increase gains from price differentials, are required JEL Classification: B26, E11, E43, E52
Rejected sickness cash benefit claims after 180 days of sick leave in the Swedish rehabilitation chain: A nationwide register-based study
Authors: Lidwall Ulrik 
Published: October 2024

Aim:Since a lack of financial security among vulnerable groups could further hamper health and well-being, this study scrutinises factors predicting rejected prolonged sickness cash benefit claims among people on compensated sick leave of more than 180 days with a rejection between days 181 and 365.Methods:All 246,872 claims for employed people on sick leave recorded in the Swedish official statistics register between January 2018 and June 2021 were analysed. Claim outcome was evaluated using logistic regression with odds ratios recalculated to relative risks (RR) with 95% confidence intervals (CI), mutually adjusted for sociodemographic, work and health-related factors.Results:Overall, 46,611 (19%) of the claims were rejected, with slightly lower rates among women (RR=0.97; 95% CI 0.95–0.99). Musculoskeletal diseases had the highest rejection rates (RR=1.84; 95% CI 1.75–1.94) followed by injuries (RR=1.57; 95% CI 1.50–1.64) and symptoms (RR=1.51; 95% CI 1.46–1.56). Mental disorders also had above-average rates (RR=1.14; 95% CI 1.09–1.19), whereas the lowest rates were found among pregnancy-related diagnoses (RR=0.13; 95% CI 0.12–0.14) and neoplasms (RR=0.18; 95% CI 0.18−0.18). Higher rates were found among immigrants (RR=1.37; 95% CI 1.34–1.40), those with only primary education (RR=1.09; 95% CI 1.06–1.12) and among blue-collar workers. The regional variation was substantial (RR range 0.41–1.72).Conclusions:High rejection rates were found for complex diagnoses and diagnoses with presupposed work ability in physically lighter occupations and among groups with assumed precarious positions at the labour market. Systematic differences in rates were identified between geographic regions. More studies are warranted to conclude if the differences found could be justified by other factors.
Efficacy of Occupation-Based Intervention in Promoting Well-Being Among Occupational Therapy Graduate Students
Authors: Espiritu Elena Wong , Chang Pei-Fen , Evetts Cynthia L. , Adams Joshua 
Published: October 2024

Background: Occupational therapy graduate students report poor well-being during their educational experience. Objective: This convergent mixed-methods study (quantitative approach presented) examined the effectiveness of an occupation-based intervention in promoting well-being. Methodology: Forty-one entry-level doctorate students (intervention = 18, control = 23) completed four standardized measures at three timepoints. The manualized intervention included six 45-minute virtual synchronous sessions, once per week. Data were analyzed using two-way mixed analysis of variance (ANOVA). Results: Statistically significant differences in well-being ( p = .024, [Formula: see text] = .09), self-compassion ( p = .006, [Formula: see text] = .12), and engagement in meaningful occupations ( p = .014, [Formula: see text] = .10) between groups, indicating intervention effectiveness. Conclusion: Intervention study participants were self-compassionate and intentional about promoting their well-being; therefore, increasing their participation in a variety of meaningful occupations moved them toward more occupational balance and improved well-being. This occupation-based intervention could be offered to promote student well-being through engagement in meaningful occupations.
Use of Five Complementary Health Modalities Relevant to Lifestyle Medicine: A 2020 Survey of Northern California Adults Aged 35-79 years
Authors: Qian Cindy W. , Lo Joan C. , Ramalingam Nirmala D. , Gordon Nancy P 
Published: October 2024

Introduction Complementary health (CH) modalities can be used as part of a Lifestyle Medicine (LM) approach to preventing and managing chronic conditions. Methods This cross-sectional study used data for respondents to the 2020 (N = 6,715) and 2014/2015 (N = 11,112) cycles of a Northern California health plan member survey to estimate use in 2020 of five CH modalities relevant to LM: vegetarian/vegan diet, mind/body stress management techniques (MBSM), yoga/Pilates, massage therapy, and prayer/spiritual practice. Use was estimated by sex and racial/ethnic group (White, Black, Latino, Asian/PI)) for ages 35-64 and 65-79 years and for adults 35-79 years with diabetes, hypertension, heart disease, fair/poor sleep quality, and chronic stress. CH use in 2020 was compared to 2014/2015. Results In 2020, 53% of adults used ≥1 of these CH modalities, including 8.4% vegetarian/vegan diet, 25.8% MBSM, 23.7% prayer/spiritual practice, 16.5% yoga/Pilates, and 17.7% massage. Sex, age group, and racial/ethnic differences were seen in use of most CH modalities, and CH modality use varied by health condition. Significant increases from 2014/2015 to 2020 were seen in use of MBSM and yoga/Pilates, vegetarian/vegan diet, and prayer/spiritual practice. Conclusion There is substantial opportunity to increase use of CH modalities within a LM approach to preventing and managing chronic health conditions.
Using non-inferiority test of proportions in design of randomized non-inferiority trials with time-to-event endpoint with a focus on low-event-rate setting
Authors: Ji Lingyun , Alonzo Todd A 
Published: October 2024

Background/aims For cancers with low incidence, low event rates, and a time-to-event endpoint, a randomized non-inferiority trial designed based on the logrank test can require a large sample size with significantly prolonged enrollment duration, making such a non-inferiority trial not feasible. This article evaluates a design based on a non-inferiority test of proportions, compares its required sample size to the non-inferiority logrank test, assesses whether there are scenarios for which a non-inferiority test of proportions can be more efficient, and provides guidelines in usage of a non-inferiority test of proportions. Methods This article describes the sample size calculation for a randomized non-inferiority trial based on a non-inferiority logrank test or a non-inferiority test of proportions. The sample size required by the two design methods are compared for a wide range of scenarios, varying the underlying Weibull survival functions, the non-inferiority margin, and loss to follow-up rate. Results Our results showed that there are scenarios for which the non-inferiority test of proportions can have significantly reduced sample size. Specifically, the non-inferiority test of proportions can be considered for cancers with more than 80% long-term survival rate. We provide guidance in choice of this design approach based on parameters of the Weibull survival functions, the non-inferiority margin, and loss to follow-up rate. Conclusion For cancers with low incidence and low event rates, a non-inferiority trial based on the logrank test is not feasible due to its large required sample size and prolonged enrollment duration. The use of a non-inferiority test of proportions can make a randomized non-inferiority Phase III trial feasible.