bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Examination of the Impact of Attention-Deficit Hyperactivity Disorder on IQ: A Large Controlled Family-Based Analysis
Authors: Biederman Joseph , Fried Ronna , Petty Carter , Mahoney Laura , Faraone Stephen V 
Published: January 2017

Objective: Although children with attention-deficit hyperactivity disorder (ADHD) have, on average, lower intelligence quotient (IQ) scores than control subjects, the reasons for these deficits remain unknown. Because IQ is highly familial, we investigated whether children with ADHD have a decrement in IQ from expectations based on parental IQ. Method: Subjects were 276 children with ADHD and 239 control subjects of similar age and sex. Expected IQ was calculated based on biological parents' estimated IQ. A significant discrepancy between observed and expected estimated IQ was defined by a child scoring 15 IQ points or more lower than expected, based on parental IQ. Results: Compared with control subjects, children with ADHD were significantly more likely to have lower than expected estimated IQ scores based on parental IQ, though this finding was accounted for by a small subgroup of children with ADHD who had an IQ 15 points or more lower than expected, based on parental IQ. These children were more likely to be female, have higher psychopathological, neuropsychological, educational, and interpersonal deficits, as well as higher rates of perinatal complications. Conclusions: Group differences in IQ scores between children with and without ADHD reported in the literature may be accounted for by a subgroup of children with ADHD who have a large decrement in IQ from expectations based on parental IQ. Although perinatal complications may explain these findings, more work is needed to better understand the etiology of these IQ deficits.
Psychoanalytic Contributions to the Study of Gender Issues
Authors: Barbieri Norma B 
Published: January 2017

Objective: To explore the issue of gender development and its applications and implications with respect to dynamic psychiatry. Method: Gender study is approached in this paper as a continually evolving process of thinking about male and female attributes, similarities, and differences. The paper reviews a specific thematic area of the extensive literature on the subject. Results: Gendered psychosexual development and identity construction are intertwined and determined by multibiopsychosocial factors. Freud's theory on femininity is briefly reviewed from the perspective of new theoretical developments. Conclusions: The paper highlights the fact that gender is becoming a useful conceptual tool in clinical practice, teaching, and neurosciences.
The Economic Burden of Schizophrenia in Canada
Authors: Goeree Ron , O'Brien Bernie J , Goering Paula , Blackhouse Gordon , Agro Karen , Rhodes Anne , Watson Jan 
Published: January 2017

Objective: To estimate the financial burden of schizophrenia in Canada in 1996. Method: Using a prevalence-based approach, all direct health care costs, administrative costs of income assistance plans, and costs of incarceration attributable to schizophrenia were determined. Also included was the value of lost productivity associated with premature mortality and morbidity. In addition to using published papers and documents, direct contact was made with representatives from various provincial and federal programs for estimates of the direct health care and non-health care costs. Results: The estimated number of persons with schizophrenia in Canada in 1996 was 221 000, with equal distribution between males and females. The direct health care and non-health care cost was estimated to be $1.12 billion in 1996. In addition, another $1.23 billion in lost productivity associated with morbidity and premature mortality was attributable to schizophrenia. Conclusions: The total financial burden of schizophrenia in Canada was estimated to be $2.35 billion in 1996. The largest category of cost was morbidity (52%), followed by acute care and psychiatric hospital admissions (14% and 10% respectively). Given the magnitude of these cost estimates, there are large potential cost savings with more effective management and control of this debilitating disease.
Methylmercury in fish from the southern Baltic Sea and coastal lagoons as a function of species, size, and region
Authors: Polak-Juszczak Lucyna 
Published: January 2017

Background: Methylmercury (MeHg) is a highly toxic compound that traverses the blood–brain barrier with deleterious effects to the central nervous system. Exposure is generally through the ingestion of contaminated fish. Fish are a main source of MeHg. Goals and methods: The aim of this study was to determine the dependence of MeHg concentrations on fish species and age, the percentage of MeHg in total mercury (THg) and risk assessment depending on the size of fish. Assays of THg and MeHg were performed on the muscle tissues of 18 species of fish. Results: The investigations indicated there were differences in the mercury concentrations depending on fish size. THg and MeHg concentrations in the muscles of fish species that have a wide length distribution were strongly, positively correlated with fish length. However, concentrations of MeHg were strongly, positively correlated with those of THg in all the fish species investigated. Variation in the percentage share of MeHg in THg in the muscles of fish of large sizes was also noted within species, but this correlation was not noted in small-sized fish. The dose of MeHg in small-sized fish species was estimated and the risk posed to consumer health was assessed using mean MeHg concentrations determined for different fish species. Conclusions: For species of fish that occur within a wide length distribution, the dose of MeHg should be assessed separately in different length classes. Fish consumption of small-sized species poses no health risk.
Meditation as a Health Patterning Modality in Nursing Practice
Authors: Malinski Violet M. 
Published: January 2017

Abstract: Meditation has been practiced throughout the centuries. This article explores meditation as a health patterning modality for nurses to employ for themselves and to facilitate clients' knowing participation in their change process. The theoretical framework for this interpretation is Rogers' Science of Unitary Human Beings. Meditation has the potential to promote awareness of the experience of flow in the human/environment patterning process. Out of this evolves an expanded awareness of creative potentials for change. Two clinical vignettes are offered to illustrate this process. Summary: Meditation is a health patterning modality that can facilitate knowing participation in change. It broadens awareness of potentials that can be actualized as nurses and clients seek to promote their own health and well-being. Meditation can assist both in experiencing the rhythm of their human/environment mutual process and open them to an expanded field image. According to Rogers, this experiencing is pandimensional, transcending traditionally perceived limitations of space and time. Meditation opens the door onto new and creative potentialities in the process of becoming.
Cross-National Comparison of Capitation Funding: The American, British and Dutch Experience
Authors: Persaud D. , Narine L. 
Published: January 2017

In this paper we review the performance of the capitation payment systems of three countries—he Adjusted Average Per Capita Cost (AAPCC) system used in the United States to reimburse Health Maintenance Organizations (HMOs) for insuring Medicare recipients, a somewhat similar system in the Netherlands which reimburses third-party payers for insuring the entire population and a weighted system utilized in Britain for regional funding. Our review revealed significant problems with the current version of the AAPCC formula as there is evidence of the biased selection of beneficiaries and actual losses to Medicare through its use. Furthermore, several studies show that the demographic adjusters utilized in the AAPCC formula are extremely poor predictors of future healthcare utilization relative to the potential of direct and indirect health status measures. The Dutch experience with capitated funding has been similar to that of the United States. While Dutch researchers have built on the work of their American counterparts they acknowledge that further work is needed before a fully functional system is implemented. Britain's weighted system has fulfilled its original mandate to redistribute healthcare resources based on population need but recent changes giving increased influence to age weighting could reverse some of these gains. A number of proposed improvements to these risk adjustment problems were reviewed including the development of diagnostic cost groups, the coexisting hierarchical conditions model and the use of community-rated high-risk pooling. The findings from this study can help others narrow the alternatives they need to consider when thinking of introducing capitation funding or refining already existing systems.
Suggested Screening Guidelines for Familial Colorectal Cancer
Authors: Hodgson S V , Bishop D T , Dunlop M G , Evans D G R , Northover J M A 
Published: January 2017

Guidelines for screening for colorectal cancer in subjects with a positive family history of the disease, without the use of DNA based screening, are outlined. These suggestions are derived from (a) the experience of screening 644 subjects at an estimated lifetime risk of dying from colorectal cancer of 10% or more, in the StMark's Family Cancer Clinic, over six years, and (b) a review of published studies, particularly incorporating the experience of the International Collaboration Group on Hereditary Non-polyposis Colorectal Cancer (HNPCC). Selection of subjects for surveillance depends upon the empirical evaluation of their risk of colorectal cancer, based upon family history details, with the exclusion of a diagnosis of familial adenomatous polyposis in the family. When DNA predictive tests for genes predisposing to HNPCC are available, surveillance can be directed at subjects with a germline mutation known to confer an increased genetic risk of colorectal cancer and discontinued in those at lower (or average) risk. In many subjects, however, DNA testing may still not be possible because of the failure to identify a predisposing mutation in an affected subject in their family. Any surveillance protocol can only be evaluated by long term follow up of those subjects in multiple centres.
Short Stature: Does it Matter? A Review of the Evidence
Authors: Voss Linda D 
Published: January 2017

Short stature is widely regarded to be a liability, but despite the importance commonly ascribed to the psychological impact of physique, there is a paucity of methodologically sound research on the topic. The question of growth hormone therapy for a short, but otherwise normal child is still controversial. The justification for such treatment will depend not only on whether a marked improvement in height can be achieved but also on whether short stature can be shown to be an appreciable handicap, either in childhood or later in life. There is some evidence, though much is anecdotal, to suggest that the short statured adult is disadvantaged both socially and economically. There are no conclusive data as yet, however, to suggest that short statured children, either before or during early adolescence have significantly lower scores on conventional psychometric testing than children of average stature. Possibly, the problems associated with short stature will only emerge in the older adolescent, but for the present, alternative, less expensive forms of treatment should be considered for those children apparently unable to cope.
Screening for Colorectal Cancer by Once Only Sigmoidoscopy: A Feasibility Study in Turin, Italy
Authors: Senore Carlo , Segnan Nereo , Rossini Francesco P , Ferraris Roberto , Cavallero Mariella , Coppola Franco , Pennazio Marco , Atkin Wendy S 
Published: January 2017

Objectives –To assess the impact on compliance of three invitation methods, as well as the acceptability and efficacy of two bowel preparation regimens, for endoscopic screening in the general population. Methods –1170 subjects (men and women aged 55 to 59, in the rosters of a sample of general practitioners (GPs) in Turin), were randomly allocated to one of three invitation groups (A: personal letter, signed by GP, with a pre-fixed appointment; B: same as for A + letter supporting the study by a well known scientist; C: letter signed by the study coordinator, NS) and two preparation regimens (i: one enema, self administered at home two hours before the test; ii: two enemas, administered the night before and two hours before the test). A postal reminder was mailed to non-attenders. A sample of non-responders was contacted for a telephone interview by a trained nurse. Written consent was obtained from all subjects undergoing the test. Results –A total of 278 subjects attended for sigmoidoscope screening. An invitation from the GP alone produced the highest response rate (compliance: A = 29.3%; B = 24.9%; C = 26.8%). A single enema was as effective as two enemas in achieving satisfactory preparation for the test: the proportion of subjects invited to repeat the test was 8.1% in the single enema group, and 9.6% in the group receiving two enemas. Conclusions –Compliance with this screening procedure tends to be low. One enema, self administered two hours before sigmoidoscopy, can ensure a satisfactory bowel preparation.
Screening for Toxoplasmosis in Pregnancy: What is the Evidence of Reducing a Health Problem?
Authors: Eskild Anne , Oxman Andy , Magnus Per , Bjorndal Arild , Bakketeig Leiv S 
Published: January 2017

Objectives— Toxoplasma gondii is a parasite which may give rise to congenital infection. Screening pregnant women for antibodies against toxoplasmosis is being debated in many countries. The preventive impact of toxoplasmosis screening of pregnant women depends on the magnitude of disease caused by congenital toxoplasmosis (incidence x transmission rate to fetus x diseased proportion of infected children), on the one hand, and the preventable proportion of disease (sensitivity of the screening test x efficacy of the treatment x compliance), on the other. In this study the preventive impact of screening pregnant women for toxoplasmosis antibodies is assessed by letting the value for these variables change within reasonable limits. Methods— To obtain information on these variables, relevant publications were reviewed in the Medline database from 1983 to February 1996 and the Cochrane Pregnancy and Childbirth Database. References in review articles on congenital toxoplasmosis were also studied. Results— The literature review showed that no population based prospective studies of the natural history of toxoplasmosis infection during pregnancy, nor any randomised controlled trials of the efficacy of antiparasitic treatment, had been carried out. In the empirical studies which have been performed the values of most variables show considerable differences. According to these values, the estimates in this study of the impact of toxoplasmosis screening in pregnancy may range from 0 to 40 children in whom disease is preventable per 100 000 pregnant women susceptible to toxoplasmosis infection. Conclusion— Sufficient scientific evidence is not yet available to propose screening for toxoplasmosis in pregnant women, and efforts should be made to provide such knowledge. Also, the magnitude of the negative impact of screening, such as induced abortion of healthy fetuses, anxiety in women with false positive screening tests, and side effects of treatment, has not been sufficiently examined.
A Comparison of Two View and One View Mammography in the Detection of Small Invasive Cancers : Results from the National Health Service Breast Screening Programme
Authors: Blanks R G , Moss S M , Wallis M G 
Published: January 2017

Objective— To examine the effect of using two view mammography in comparison with one view mammography in the detection of small (<15 mm) invasive cancers. Setting— Screening programme data from National Health Service breast screening programme (NHSBSP). Methods— Data were collated from all screening programmes in the United Kingdom on standard “Korner” returns (KC62 forms) for the screening year 1 April 1994 to 31 March 1995. The comparison of invasive cancer detection rates by programmes using one and two view mammography with indirectly age standardised invasive cancer detection rates. Results— Programmes using two views for women attending their prevalent screen (first screen) in the NHSBSP detected 3% more non-invasive/microinvasive cancers, 7% more large invasive cancers (⩽15 mm), and 42% more small invasive cancers (<15 mm) than programmes using one view mammography. Conclusions— The success of the screening programme depends largely on the ability of individual programmes to detect small invasive cancers. The results suggest that the benefit of using two view mammography is largely in the increased detection of these cancers.
Key differences in treatment-seeking stimulant users attending a specialised treatment service: a means of early intervention?
Authors: Arunogiri Shalini , Petrie Margret , Sharkey Michelle , Lubman Dan I 
Published: January 2017

Objectives: Few people who use stimulants seek clinical treatment. This study sought to describe a cohort of stimulant users who attended a stimulant-specific treatment service, Access Point, in Melbourne, Australia between 2008 and 2014. Methods: A retrospective audit of the records of adults ( n = 175) who sought treatment for stimulant use at a stimulant-specific outpatient treatment service was conducted. Results: Service users had a median age of 32 (range = 19–54). Most stimulant users were in part- or full-time employment (53.6%) and had stable accommodation (85%). There was a high rate of mental health comorbidity, with over half (52%) reporting a previous history of mental health problems, while one-third (33%) reported previous suicide attempts. There was a high rate (48%) of previous methamphetamine-associated psychosis, which was significantly correlated with frequency of use ( x2 = 13.698, p = 0.008). Conclusions: This study supports the potential of a targeted and specialised treatment service as a means of early intervention for stimulant users. The high prevalence of methamphetamine-associated psychosis history in this group suggests that frequent use of stimulants increases the risk of psychosis, even among high-functioning individuals.
Anaphylactoid Reaction to Intravenous Acetylcysteine Associated with Electrocardiographic Abnormalities
Authors: Bonfiglio Mark F. , Traeger Sheldon M. , Hulisz Darrell T. , Martin Bradley R. 
Published: January 2017

OBJECTIVE: To review the potential for anaphylactoid reactions to intravenously administered acetylcysteine when used in the treatment of acetaminophen overdose. This case is unique in that electrocardiographic changes, including ST segment depression and T-wave inversion were associated with the episode and complicated the diagnosis. DATA SOURCES: Reference articles and letters are identified in the text. DATA SYNTHESIS: Intravenous administration of acetylcysteine has been used in the treatment of acetaminophen overdose. This route may be considered in some clinical situations where oral therapy is complicated. Anaphylactoid reactions, including cutaneous eruptions, flushing, chest pain, tachycardia, and fever have been reported in up to three percent of patients receiving intravenous acetylcysteine. The nature of these reactions and evidence concerning their etiology suggest a histamine-release phenomenon. Response to intervention with antihistamines and the safety of further acetylcysteine administration are discussed. CONCLUSIONS: This case illustrates a variant anaphylactoid reaction to intravenously administered acetylcysteine and emphasizes the need for practitioners to consider the potential for these reactions prior to initiation of therapy and indicates appropriate treatment of these reactions.
A Study of Adverse Effects of High-Dose Intravenous (Pulse) Methylprednisolone Therapy in Patients with Rheumatic Disease
Authors: Baethge Bruce A. , Lidsky Martin D. , Goldberg Jerry W. 
Published: January 2017

OBJECTIVE: To determine the frequency of significant adverse effects associated with high-dose intravenous methylprednisolone therapy (HIVMP) given as methylprednisolone 1 g/d for three consecutive days. DESIGN: Retrospective study of consecutive patients. SETTING: Department of Veterans Affairs Medical Center (VAMC), university teaching hospital, and private outpatient clinic. PATIENTS: Eighty-four patients given HIVMP for systemic rheumatic disease. MEASUREMENTS: Subjective complaints were elicited via a standardized questionnaire that identified adverse effects through organ system review. Medical records were reviewed for adverse effects occurring within two weeks of HIVMP therapy. RESULTS: Two hundred seventy-five HIVMP treatments were examined by either patient questionnaire (76 patients) and/or chart review (78 patients). Sixty-five patients described symptoms after HIVMP treatment. Most symptoms were transient in duration, mild in severity, and required no medical treatment. Chart review found 42 possible complications occurring within two weeks of HIVMP therapy. In 18 instances medical intervention was required for problems that included hypertension, seizures, gastric erosions, sepsis, and other infections. It is impossible to attribute all of the complications to HIVMP alone because of underlying disease, use of other medications at the time of therapy, or both. CONCLUSIONS: HIVMP has an acceptably low risk of significant adverse effects.
Outcomes After Interpositional Arthroplasty of the First Metatarsophalangeal Joint
Authors: Aynardi Michael C. , Atwater Lara , Dein Eric J. , Zahoor Talal , Schon Lew C. , Miller Stuart D. 
Published: January 2017

Background: For patients with hallux rigidus seeking a motion-sparing procedure, interposition arthroplasty is an alternative to fusion. The purpose of this study was to report patient outcomes after interpositional arthroplasty for hallux rigidus. Methods: All patients undergoing interpositional arthroplasty at our institution from 2001 to 2014 were identified and a retrospective chart review was performed. Follow-up was conducted through a telephone survey to obtain survivorship, satisfaction, and functional scores. Survivorship of the interpositional arthroplasty procedure was defined as no subsequent surgery on the hallux after the index procedure. Patients were excluded for incomplete records. Complications were recorded. From 2001 to 2014, 183 patients were identified. Of these, 14 were excluded for incomplete data, leaving 169 patients. Of these, 133 had an average follow-up of 62.2 months (range, 24.3 months to 151.2 months). Results: The overall failure rate was 3.8% (5/133). Patient-reported outcome was rated as excellent in 65.4% (87/133) or good in 24.1% (32/133) of patients and fair or poor in 10.5% (14/133) of patients. Of 133 patients, 101 (76%) were able to return to fashionable or regular footwear. The infection rate was 1.5% (2/133). Patient-reported cock-up deformity of the first metatarsophalangeal joint (MTPJ) occurred in 4.5% (6/133) of patients. In addition, 17.3% (23/133) of patients reported metatarsalgia of the second or third MTPJ at the time of final follow-up, and there was no significant difference between interposition types ( P = .441). Conclusion: Interpositional arthroplasty for hallux rigidus was found to have excellent or good results in most patients at a mean follow-up of 62.2 months. Level of Evidence: Level IV, retrospective case series.