bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is personal physiology-based rapid prediction digital twin for minimal effective fentanyl dose better than standard practice: a pilot study protocol
Authors: Cukic Milena , Annaheim Simon , Bahrami Flora , Defraeye Thijs , De Nys Katelijne , Jörger Markus 
Published: September 2024

IntroductionPatients with advanced cancer frequently suffer from chronic, severe disabling pain. Opioids such as morphine and fentanyl are commonly used to manage this pain. Transdermal drug delivery systems are important technologies for administering drugs in a non-invasive, continuous and controlled manner. Due to the narrow therapeutic range of fentanyl, individualised dosing is essential to avoid underdosing or overdosing. Standard clinical calculation tools for opioid rotation however do not include important patient characteristics that account for interindividual variability of opioid pharmacology.Methods and analysisWe developed a clinical protocol to optimise individual fentanyl dosing in patients with advanced cancer switching from oral or intravenous opioids to transdermal fentanyl by using a physics-based digital twin (DT) that is fed by important clinical and physiological parameters. Individual tailoring of transdermal fentanyl therapy is an approach with the potential for personalised and effective care with an improved benefit-risk ratio. However, clinical validation of physics-based digital twins (PBDT) dosing is crucial to proving clinical benefit.Therapeutic drug monitoring will allow to validate the accuracy of PBDT predictions. Additional monitoring for breathing dynamics, sequential pain levels and fentanyl-related adverse events will contribute to evaluating the performance of PBDT-based dosing of transdermal fentanyl. The primary objective of the study is to develop an experimental protocol to validate DT-guided fentanyl dosing in patients with advanced cancer. This clinical study will bring individualised opioid dosing closer to clinical practice.Ethics and disseminationStudy documents have been approved by the responsible Ethics Committee and study initiation is planned for late summer 2024. Data will be shared with the scientific community no more than 1 year following completion of the study and data assembly.
Exploring experiences and coping strategies of the surveillance of indeterminate pulmonary nodules: a qualitative content analysis among participants in the SCAPIS trial
Authors: Dai Ydrefelt Ying , Andersson Elisabeth , Bolejko Anetta 
Published: September 2024

ObjectiveTo elucidate experiences and coping strategies among adults in the surveillance of indeterminate pulmonary nodules detected with CT in the population-based Swedish CardioPulmonary bioImage Study (SCAPIS).DesignA qualitative study of conventional content analysis.SettingsThe study was conducted at a university hospital in a southern region of Sweden. The SCAPIS setting is similar to the first round of a population-based lung cancer screening programme.ParticipantsParticipants in SCAPIS who had experienced psychosocial consequences of the surveillance were eligible. Participants of both genders, current, former and non-smokers and of different follow-ups in the surveillance were included. Face-to-face semi-structured interviews with 19 participants were performed using an interview guide with open-ended questions. The participants were aged 56–68 years. Nine were women, 6 and 13 were non-smokers and smokers or former smokers, respectively, and all participants had undergone at least one follow-up of the lungs in the surveillance programme.ResultsThe results depicted an emotional and mental journey for the participants from being distressed when informed about the need of surveillance, and realising their risks of getting sick if they did not take care of their own health, to eventually gathering the strength to cope with the situation, so the surveillance was finally valued with trust and satisfaction. The experiences and coping strategies in the surveillance programme developed a revelation of the value of health consciousness among the participants.ConclusionThe study results demonstrated that a surveillance programme of pulmonary nodules might develop health consciousness among people. Still, some individuals might experience psychosocial consequences of the surveillance of indeterminate nodules. Therefore, healthcare professionals should be facilitated to perform person-centred communication to support individuals under surveillance. Preventive care to engage individuals as partners in the management of their own health should receive more attention and needs to be explored.
Culturally safe community agency health promotion capacity for diverse equity-seeking women: a rapid theoretical review
Authors: Nelson Elle , Susmita Susmita , Allana Saleema , Amodu Oluwakemi C , Weerasinghe Swarna , Simpson Andrea N , Ziegler Erin , Gagliardi Anna R 
Published: September 2024

ObjectivesImmigrant and sexually/gender-diverse women (henceforth, women) face inequities in access to and quality of care. As a result, many seek health information from community agencies perceived as culturally safe. We aimed to generate knowledge on capacity needed for culturally safe community agency health promotion.DesignTheoretical rapid review.Data sourcesStudies identified in MEDLINE, EMBASE, CINAHL, PsycINFO, Sociological Abstracts, Cochrane Library and the Joanna Briggs Institute Database of Systematic Reviews.Eligibility criteriaStudies published in 2013 or later on health promotion for ethnoculturally, sexually and gender-diverse women led by community agencies (eg, settlement, cultural, support and faith).Data extraction/synthesisWe extracted data on study characteristics, cultural tailoring, implementation with the Reach Effectiveness Adoption Implementation framework and health promotion capacity with the New South Wales framework.ResultsWe included 19 studies published from 2017 to 2023. Most focused on health promotion to African or Latin American persons in faith-based organisations. Few studies focused solely on women, and no studies focused on or included 2SLGBTQ women. Few studies described cultural tailoring beyond the use of participants’ first language. Training of community health workers (CHWs) to deliver health promotion education, and CHW in-person group training of health promotion participants on a wide range of topics resulted in improved knowledge, self-efficacy, intention to modify behaviour, behaviour change and health outcomes. A few studies yielded some insight into what community agencies need to enable health promotion: dedicated funding and personnel, training in healthcare issues, space and partnerships with academic and healthcare organisations.ConclusionsThis study confirmed and enhanced our understanding of the health promotion role of community agencies and identified gaps that can inform future research on how to achieve culturally safe community agency health promotion for diverse women.
Impact of Barrow’s entropy on topological classification of higher-dimensional black holes
Authors: Mohamed Abdelhay Salah , Shahzad M. Umair , Mehmood Aqsa , Zotos Euaggelos E. 
Published: September 2024

In this paper, we explore the impact of Barrow’s entropy on the topological classification of d-dimensional black holes (BHs). Specifically, we examine the Gauss–Bonnet (GB) and singly rotating Kerr black holes (KBHs) as well as their AdS counterparts. We notice that Barrow’s entropy significantly influences the topological numbers of these BHs. To understand these effects, we use the thermodynamic domain — the space defined by thermodynamic variables like temperature and pressure — to study topologically inspired defects in the BHs. These defects are points in the thermodynamic domain where singular or discontinuous behavior occurs. By computing the winding numbers of these defects, which are integers that count how many times a loop around the defect encircles the origin, we can understand the local and global topology of the BHs. Our analysis suggest that the topological number [Formula: see text] derived from Barrow’s statistics differs from the one obtained using Gibbs–Boltzmann statistics. Furthermore, we observe that BHs can undergo topological phase transitions that characterize them in different thermodynamic topological classes. Overall, these findings demonstrate the importance of Barrow’s entropy in understanding the topological classification of BHs, and highlight the potential for further research in this area.
The Schwinger pair production method in the framework of non-commutative phase space coordinates and its applications
Authors: Benzair Hadjira , Moures Nadjiba , Boudjedaa Tahar 
Published: September 2024

In noncommutative phase space (NCPS), we investigate the pair creation rate for the problem of scalar and spinorial particles emerging from a vacuum under the influence of uniform external electromagnetic fields using the Schwinger formal technique. It is demonstrated that under specific conditions, where the speed of light c approaches the Fermi velocity [Formula: see text] and [Formula: see text] (with [Formula: see text] representing the cyclotron frequency), the behavior of the Dirac oscillator problem in a uniform electromagnetic field within NCPS is akin to the monolayer graphene problem in NCPS. In addition, the production probability per unit volume per unit time is discussed, along with the limits of parameter deformations.
Revisiting Sentiment Analysis for Software Engineering in the Era of Large Language Models
Authors: Zhang Ting , Irsan Ivana Clairine , Thung Ferdian , Lo David 
Published: September 2024

Software development involves collaborative interactions where stakeholders express opinions across various platforms. Recognizing the sentiments conveyed in these interactions is crucial for the effective development and ongoing maintenance of software systems. For software products, analyzing the sentiment of user feedback, e.g., reviews, comments, and forum posts can provide valuable insights into user satisfaction and areas for improvement. This can guide the development of future updates and features. However, accurately identifying sentiments in software engineering datasets remains challenging.
This study investigates bigger large language models (bLLMs) in addressing the labeled data shortage that hampers fine-tuned smaller large language models (sLLMs) in software engineering tasks. We conduct a comprehensive empirical study using five established datasets to assess three open source bLLMs in zero-shot and few-shot scenarios. Additionally, we compare them with fine-tuned sLLMs, using sLLMs to learn contextual embeddings of text from software platforms.
Our experimental findings demonstrate that bLLMs exhibit state-of-the-art performance on datasets marked by limited training data and imbalanced distributions. bLLMs can also achieve excellent performance under a zero-shot setting. However, when ample training data are available or the dataset exhibits a more balanced distribution, fine-tuned sLLMs can still achieve superior results.
Efficacy and Safety of Ertugliflozin Compared to Placebo in Patients With Type 2 Diabetes: An Updated Systematic Review and Meta‐Analysis
Authors: Kamrul-Hasan A. B. M. , Alam Muhammad Shah , Talukder Samir Kumar , Hannan Mohammad Abdul , Dutta Deep , Nagendra Lakshmi , Selim Shahjada 
Published: September 2024

Background: No comprehensive meta‐analysis has evaluated the efficacy and safety of ertugliflozin compared to a placebo in patients with Type 2 diabetes (T2D) until now. This meta‐analysis fills this gap in knowledge.Methods: A systematic search was carried out in electronic databases to identify randomized controlled trials (RCTs) that included patients with T2D receiving ertugliflozin in the treatment group and placebo in the control group. The change in HbA1c from the baseline values was the primary outcome, whereas changes in plasma glucose and other metabolic parameters and adverse events (AEs), including hypoglycemia, were the secondary outcomes.Results: Seven RCTs involving 7283 subjects met the inclusion criteria. Ertugliflozin outperformed placebo in reducing HbA1c in both 5 mg (MD −0.62%, 95% CI [−0.80, −0.44], p < 0.00001, I2 = 91%) and 15 mg (MD −0.69%, 95% CI [−0.91, −0.47], p < 0.00001, I2 = 93%) doses. A higher proportion of patients achieved HbA1c < 7.0% with ertugliflozin than with placebo. Ertugliflozin was also superior to placebo in lowering fasting plasma glucose (FPG), body weight, and systolic and diastolic blood pressure (BP). Ertugliflozin and placebo had comparable AE profiles, including urinary tract infection (UTI) and hypoglycemia, except for the greater risk of genital mycotic infections (GMIs) with ertugliflozin. Ertugliflozin 5 and 15 mg have equivalent efficacy and safety profiles except for greater weight reduction with ertugliflozin 15 mg.Conclusion: Ertugliflozin has a good glycemic efficacy and a reassuring safety profile in managing T2D.Trial Registration: Registration number: CRD42023456450.
COVID‐19‐Induced Refractory Symptomatic Hypocalcemia in a Patient With Parathyroid Gland Reimplantation
Authors: Tse Crystal , Yeung Ho-Man 
Published: September 2024

Background: Several cases of severe hypocalcemia in the setting of COVID‐19 have been reported. The proposed mechanisms include direct viral interaction with ACE2 receptors in the parathyroid gland, viral chelation of calcium, worsening hypovitaminosis D, critical illness leading to unbound fatty acids binding calcium, and inflammatory cytokines leading to PTH resistance. Given the life‐threatening nature of hypocalcemia, this underrecognized phenomenon should be on the forefront of the clinician’s attention. This case highlights a rare manifestation of COVID‐19 and further complicated by the patient’s reimplanted parathyroid gland.Presentation: A 73‐year‐old female with primary hyperparathyroidism status post parathyroidectomy with reimplantation in the left forearm presented with 4 days of viral syndrome, found to have tetany and Chvostek’s sign on physical exam. Pertinent laboratory abnormalities included calcium 5.3 mg/dL, ionized calcium 0.44 mmol/L, magnesium 1.4 mg/dL, phosphorous 5.5 mg/dL, PTH 242 pg/mL, and 25‐OH vitamin D 56 ng/mL. Chest CT revealed multifocal pneumonia consistent with positive COVID‐19 testing. She was subsequently admitted to the ICU for severe, symptomatic hypocalcemia and was initiated on a continuous calcium infusion, remdesivir, baricitinib, and steroids. Tetany resolved after 9 g calcium repletion, and she was transferred to the medical floor with an ionized calcium of 0.83 mmol/L. On hospital day 3, repeat ionized calcium was 0.78 mmol/L despite ongoing repletion. Given the persistence of hypocalcemia, a repeat PTH level was obtained which remained high at 487 pg/mL, suggesting ongoing PTH interference in the setting of COVID‐19. PTH was obtained from the right (nonimplanted) arm which was normal at 74 pg/mL. This indicated an appropriate PTH response from the reimplanted gland, and that ongoing hypocalcemia may be due to insufficient PTH function to maintain systemic calcium levels or a peripheral interference with PTH level. With continued calcium supplementation and treatment of COVID‐19, the patient’s calcium stabilized at 8.6 mg/dL. She was discharged on oral calcium supplementation with endocrinology follow‐up.Conclusion: Acute hypocalcemia strongly correlates with a profound inflammatory response in COVID‐19 patients. This case corroborates the cytokine/PTH hypothesis. This patient had a high PTH sampled near the reimplanted gland but an inappropriately normal PTH from the nonimplanted arm, indicating that direct viral interaction interfering with PTH release is an unlikely mechanism. This case represents a scenario where PTH can be sampled directly from the source and this type of model could aid in the process of determining the etiology of hypocalcemia in COVID‐19.
Serra and Us
Authors: Bois Yve-Alain 
Published: September 2024

Abstract
Yve-Alain Bois discusses and describes the many essays that October editors and contributors have written about Richard Serra, particularly Rosalind Krauss, Benjamin H. D. Buchloh, Yve-Alain himself, Leah Dickerman (most recently), and Hal Foster (most abundantly).
The article begins: “I don't think it is an exaggeration to say that no artist can be more immediately identified with October than Richard Serra, particularly during the journal's first decades. Several of its editors or editors-to-be wrote repeatedly about his work, in the journal and elsewhere, and he himself participated directly in the life of the publication via a lengthy interview, not to mention his unwavering financial support since issue 39 (Winter 1986).
“In 1991, The Destruction of Tilted Arc: Documents appeared in the October book series; edited by Clara Weyergraf-Serra and Martha Buskirk, it offered nearly three hundred pages of documentation concerning the legal battle waged (and lost) by the artist to prevent the destruction by the American government of the site-specific work it had commissioned for Federal Plaza in New York City (installed in 1981, it was dismantled in 1989). Needless to say, the October gang came en bloc to defend the work at the public hearing (the testimonies of Rosalind Krauss, Annette Michelson, Douglas Crimp, Benjamin Buchloh, and regular contributor Abigail Solomon-Godeau figure in the book).
“In 2000, the first volume of the October Files appeared; edited by Hal Foster, it took Serra as its subject. Memorial tributes are an awkward genre in that they are almost inevitably nostalgic and take a narcissistic turn (“me and the great man”). But what if one were simply to commemorate the prolonged interaction of the journal's editors with Serra's work by chronologically recapitulating the various instances of their engagement? This will be done with pride, for sure, but also as a duty to forestall amnesia.”
Ring Composition and the Skepticism of the De Republica
Authors: Keoseyan Benjamin 
Published: September 2024

Abstract
The fragmentary state of Cicero’s De Republica makes it difficult to see how it is a unified work. In this article, I argue that Cicero uses ring composition to unify the dialogue as a polemic against the Epicurean prohibition on political involvement. Cicero is following Plato in his use of ring composition, and just as Plato uses ring composition in the Republic to express his views about philosophical method, so does Cicero. Ring composition turns out to be central to a plausible skeptical reading of the De Republica, in which Cicero both tries to induce suspension of belief in the Epicurean prohibition on political involvement, as well as prevent the reader from unreflectively adopting his own provisionally held views, both consistent with his commitment to the pedagogical aims of Academic skeptical philosophy.
Bias, Knowledge, Skepticism, and Disagreement: Précis of Part iii of Bias: A Philosophical Study
Authors: Kelly Thomas 
Published: September 2024

Abstract
The third and final part of Bias: A Philosophical Study explores the connections between bias and some of the central topics of epistemology, including knowledge, skepticism, and disagreement. It defends the possibility of biased knowing: biased believers can sometimes know, even when they believe in accordance with their biases, and even if those biases guarantee that they would believe as they do even if the truth were otherwise. It argues that the possibility of biased knowing has significant implications for both philosophical methodology and traditional forms of skepticism. Extended consideration is given to the question of whether those of us who robustly favor our ordinary commonsense views over the possibilities that the skeptic calls to our attention are biased against skepticism in any objectionable sense. Finally, it critically examines our tendency to attribute bias to others in response to interpersonal disagreement and the epistemological significance of “the bias blind spot.”
Memories of al-Shāfiʿī’s Inquisition
Authors: Saba Elias G. 
Published: September 2024

Abstract
This paper studies an account of the “inquisition” (miḥna) of Muḥammad b. Idrīs al-Shāfiʿī (d. 204/820) by the caliph Hārūn al-Rashīd (r. 170–193/786–809). In this account, al-Shāfiʿī is twice brought to the court of the caliph in chains but he is able to win the caliph’s favor through his rhetorical eloquence. The account is compared to that of the inquisition of Aḥmad b. Ḥanbal (d. 241/855) during the reign of the caliph al-Muʿtaṣim (r. 218–227/833–42). The paper shows the resonances between the two accounts, especially the heroic resistance to the caliphal questioning and the steadfast adherence to each jurist’s theological beliefs. The story of al-Shāfiʿī’s miḥna is structured so as to create a story for him that is reminiscent of the story of Aḥmad b. Ḥanbal.
ʿAlī Jumʿa as Editor: Reviving the Ḥāshiya in Late-Twentieth-Century Egypt
Authors: Elston Mary 
Published: September 2024

Abstract
The article analyzes a 2002 edition of Tuḥfat al-murīd ʿalā Jawharat al-tawḥīd, a supercommentary written by Ibrāhīm al-Bājūrī (d. 1860) on Ibrāhīm al-Laqānī’s (d. 1632) base text in Ashʿarī theology. The edition was edited by the Muslim religious scholar and former grand mufti of Egypt, ʿAlī Jumʿa (b. 1952). The article shows that in Jumʿa’s edition taḥqīq is a practice of selecting a text that has been widely available, reframing its importance in the introduction and footnotes, and making the text understandable to contemporary readers. In his selection and framing of the text, Jumʿa situates al-Bājūrī’s ḥāshiya against Salafī opponents, while his explicit audience for the edition consists of Muslim students. The article argues that Jumʿa’s taḥqīq, which is both ideologically and pedagogically oriented, reflects his larger religiopolitical project of bolstering the authority and intellectual legacy of al-Azhar in the context of inter-Sunni rivalry in the late twentieth century.
Nature without Suffering: Herbivorisation of Predator Species for the Compassionate Stewardship of Earth’s Ecosystems
Authors: Bruers Stijn , Davis Adam James , Hojjat Sara , Koskensilta Aatu , Lepeltier Thomas , Pearce David 
Published: September 2024

Abstract
Predation causes suffering and the premature deaths of prey animals. With innovative technologies on the horizon, humanity could phase it out. We argue that herbivorisation, i.e., turning carnivorous species into herbivorous ones with biotechnologies, is better than other strategies for ending predation, because it is the one most likely to preserve environmental values such as biodiversity and receive democratic support. Pressure on vegetation in herbivorised ecosystems would increase, but fertility control could relieve this pressure. We respond to other objections and conclude that the process should be considered as a future megaproject to reduce naturogenic harms.