bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relational Intimacy Mediates Sexual Outcomes Associated with Impaired Sexual Function: Examination in a Clinical Sample
Authors: Witherow Marta Parkanyi , Chandraiah Shambhavi , Seals Samantha R. , Sarver Dustin E. , Parisi Kathryn E. , Bugan Antal 
Published: June 2017

Abstract

Background
Relational intimacy is hypothesized to underlie the association between female sexual functioning and various sexual outcomes, and married women and women with sexual dysfunction have been generally absent from prior studies investigating these associations, thus restricting generalizability.

Aim
To investigate whether relational intimacy mediates sexual outcomes (sexual satisfaction, coital frequency, and sexual distress) in a sample of married women with and without impaired sexual functioning presenting in clinical settings.

Methods
Using a cross-sectional design, 64 heterosexual married women with (n = 44) and without (n = 20) impaired sexual functioning completed a battery of validated measurements assessing relational intimacy, sexual dysfunction, sexual frequency, satisfaction, and distress. Intimacy measurements were combined using latent factor scores before analysis. Bias-corrected mediation models of the indirect effect were used to test mediation effects. Moderated mediation models examined whether indirect effects were influenced by age and marital duration.

Outcomes
Patients completed the Female Sexual Function Index, the Couple’s Satisfaction Index, the Sexual Satisfaction Scale for Women, the Inclusion of the Other in the Self Scale, and the Miller Social Intimacy Test.

Results
Mediation models showed that impaired sexual functioning is associated with all sexual outcomes directly and indirectly through relational intimacy. Results were predominantly independent of age and marital duration.

Clinical Implications
Findings have important treatment implications for modifying interventions to focus on enhancing relational intimacy to improve the sexual functioning of women with impaired sexual functioning.

Strengths and Limitations
The importance of the role relational intimacy plays in broad sexual outcomes of women with impaired sexual functioning is supported in clinically referred and married women. Latent factor scores to improve estimation of study constructs and the use of contemporary mediation analysis also are strengths. The cross-sectional design precludes any causal conclusions and it is unknown whether the results generalize to male partners, partners within other relationship structures, and non-heterosexual couples.

Conclusion
Greater relational intimacy mitigates the adverse impact of impaired sexual functioning on sexual behavior and satisfaction in women.
Active absorptive frequency selective surface
Authors: Yu Dingwang , Liu Peiguo , Dong Yanfei , Zhou Qihui , Zhou Dongming 
Published: June 2017

A novel design of absorptive frequency selective surface (AFSS) with tunable absorptive/switchable transmissive property is presented. The AFSS is comprised of a resistive surface and a metallic bandpass FSS on which PIN diodes are mounted. By changing the working state of the PIN diode, a tunable absorption performance at 3.5–11.2 GHz is achieved with a switchable transmission at the frequency of 0.83 GHz. A prototype of the proposed structure is fabricated and measured under the normal incidence.
Design of high‐performance microstrip diplexers with stub‐loaded parallel‐coupled lines
Authors: Chen Xun , Yu Xi , Sun Sheng 
Published: June 2017

A compact and high‐performance microstrip diplexer is designed by using stub‐loaded parallel‐coupled lines and half‐wavelength resonators. First, the traditional equivalent circuit of the parallel‐coupled line is extended to consider the length effect of the loaded stub. Second, by choosing the length of the stub, the multiple transmission zeros can be introduced and allocated to reduce the coupling between two signal channels and improve the isolation between two out‐put ports. Finally, a prototype of the proposed microstrip diplexer is designed and fabricated. The simulated insertion losses are 1.34 dB at 1.8 GHz (first band) and 1.28 dB at 2.4 GHz (second band), while the measured ones achieve 1.54 and 1.47 dB, respectively. More than 40‐dB isolation level is obtained over the whole concerned frequency range.
Crystal structure of tubulin tyrosine ligase-like 3 reveals essential architectural elements unique to tubulin monoglycylases
Authors: Garnham Christopher P. , Yu Ian , Li Yan , Roll-Mecak Antonina 
Published: June 2017

Significance
Tubulin is subject to diverse posttranslational modifications that constitute a code read by cellular effectors. Most of these modifications are catalyzed by tubulin tyrosine ligase-like (TTLL) family members. The functional specialization and biochemical interplay between TTLL enzymes remain largely unknown. Our X-ray structure of TTLL3, a tubulin glycylase, identifies two functionally essential architectural elements and illustrates how the common TTL scaffold was used to functionally diversify the TTLL family. We show that TTLL3 competes with the glutamylase TTLL7 for overlapping modification sites on tubulin, providing a molecular basis for the anticorrelation between these modifications observed in vivo. Our results illustrate how a combinatorial tubulin code can arise through the intersection of activities of TTLL enzymes.
Advancing the link between ocean connectivity, ecological function and management challenges
Authors: Hidalgo Manuel , Kaplan David M. , Kerr Lisa A. , Watson James R. , Paris Claire B. , Browman Howard I. 
Published: June 2017

Abstract“Ocean connectivity” is a dynamic and rapidly evolving field of research in marine science, partly because there is an increasing demand for information on connectivity that informs effective assessment and management of marine resources. Achieving this will require a better alignment between ocean connectivity tools and developments and the needs and challenges of assessments and conservation. For these reasons, the ICES Journal of Marine Science solicited contributions to the article theme set (TS), “Beyond ocean connectivity.” We briefly summarize the nine articles that appear herein, grouping them into four general topics: methodological advances, population dynamics and assessment implications of connectivity, spatial and management implications, and connectivity in ecosystem processes. We also discuss the challenges facing ocean connectivity research if it is to effectively support advancing fisheries assessment frameworks and integrated ecosystem approaches. We hope that the contributions included in this TS serve to convince managers and fisheries scientists of the need to incorporate results from research on connectivity.
National Study of Excellence and Innovation in Physical Therapist Education: Part 2—A Call to Reform
Authors: Jensen Gail M. , Hack Laurita M. , Nordstrom Terrence , Gwyer Janet , Mostrom Elizabeth 
Published: June 2017

Abstract
This perspective shares recommendations that draw from (1) the National Study of Excellence and Innovation in Physical Therapist Education research findings and a conceptual model of excellence in physical therapist education, (2) the Carnegie Foundation's Preparation for the Professions Program (PPP), and (3) research in the learning sciences. The 30 recommendations are linked to the dimensions described in the conceptual model for excellence in physical therapist education: Culture of Excellence, Praxis of Learning, and Organizational Structures and Resources. This perspective proposes a transformative call for reform framed across 3 core categories: (1) creating a culture of excellence, leadership, and partnership, (2) advancing the learning sciences and understanding and enacting the social contract, and (3) implementing organizational imperatives. Similar to the Carnegie studies, this perspective identifies action items (9) that should be initiated immediately in a strategic and systematic way by the major organizational stakeholders in physical therapist education. These recommendations and action items provide a transformative agenda for physical therapist education, and thus the profession, in meeting the changing needs of society through higher levels of excellence.
The Growing Importance of Social Skills in the Labor Market*
Authors: Deming David J. 
Published: June 2017

Abstract
The labor market increasingly rewards social skills. Between 1980 and 2012, jobs requiring high levels of social interaction grew by nearly 12 percentage points as a share of the U.S. labor force. Math-intensive but less social jobs—including many STEM occupations—shrank by 3.3 percentage points over the same period. Employment and wage growth were particularly strong for jobs requiring high levels of both math skill and social skills. To understand these patterns, I develop a model of team production where workers “trade tasks” to exploit their comparative advantage. In the model, social skills reduce coordination costs, allowing workers to specialize and work together more efficiently. The model generates predictions about sorting and the relative returns to skill across occupations, which I investigate using data from the NLSY79 and the NLSY97. Using a comparable set of skill measures and covariates across survey waves, I find that the labor market return to social skills was much greater in the 2000s than in the mid-1980s and 1990s.
Ocular Surface Changes After Sulfur Mustard Exposure in Rabbits, Monitored by Impression Cytology
Authors: Dachir Shlomit , Gutman Hila , Gore Ariel , Cohen Liat , Cohen Maayan , Amir Adina , Horwitz Vered , Kadar Tamar 
Published: June 2017

Purpose:
Ocular injuries after exposure to sulfur mustard (SM) are characterized by acute corneal erosion and inflammation of the anterior segment that may be followed by delayed corneal neovascularization and epithelial defects, associated with limbal stem cell deficiency in part of the exposed eyes. This study aimed to further clarify the mechanism of the late injury by monitoring SM-induced cytological alterations in the ocular surface, in relation to the clinical symptoms, using impression cytology (IC).

Methods:
Rabbit eyes were exposed to SM vapor (n = 20) and were clinically observed up to 4 weeks. Samples for IC were collected simultaneously from the upper bulbar conjunctiva, limbus, and cornea and then fixed and stained with periodic acid–Schiff and hematoxylin. At 1 month, animals were killed and eyes dissected and processed for histology.

Results:
Concomitant with clinical symptoms of SM ocular toxicity, IC showed significant long-term loss of conjunctival goblet cells shortly after exposure, followed by abnormal differentiation toward squamous metaplasia. Simultaneously with corneal erosion, apoptotic bodies and cellular debris were seen in the corneal epithelium, followed by regeneration at 1 week. Migration of conjunctival goblet cells toward the cornea was noted in neovascularized eyes, as early as 1 week, indicating limbal stem cell deficiency. The IC findings were supported by histological evaluation.

Conclusions:
Continuous monitoring of the ocular surface after SM exposure by IC enables earlier detection of pathology and therapeutic intervention, therefore, is recommended for routine follow-up of casualties. Prolonged loss of goblet cells may point toward the role of mucin in the pathogenesis.
Clinical Presentation and Anatomical Location of Orbital Plasmacytomas
Authors: Thuro Bradley A. , Sagiv Oded , Shinder Roman , Debnam J. Matthew , Ozgur Omar , Ng John D. , Rootman Daniel , Thomas Sheeba K. , Esmaeli Bita 
Published: June 2017

Purpose:
To evaluate the clinical and anatomical location of orbital plasmacytomas and assess local control following therapy.

Methods:
The American Society of Ophthalmic Plastic and Reconstructive Surgery Oncology Database was queried to identify patients diagnosed with orbital plasmacytoma. These patients’ records were reviewed for demographic characteristics, clinical and radiologic findings, treatments, and outcomes.

Results:
Thirty patients from 4 institutions (24 from MD Anderson Cancer Center, 3 from SUNY Downstate Medical Center, 2 from University of California, Los Angeles, and 1 from Oregon Health and Science University) were identified. Eighteen patients (60%) were diagnosed with multiple myeloma (MM) before and 11 (37%) were diagnosed with MM immediately after orbital plasmacytoma. Based on imaging, 4 distinct anatomical patterns were identified: 1) bony plasmacytoma affecting the superotemporal orbit, epidural space, and temporal fossa (15 patients; 50%); 2) discrete orbital plasmacytoma (7 patients; 23%); 3) infiltrative plasmacytoma either originating from a sinus (4 patients; 13%); or 4) originating from the orbital floor and infiltrating facial soft tissue (4 patients; 13%). Of the 29 patients with available treatment data, 2 had radiation only, 3 had chemotherapy only, 6 had chemoradiation, and 18 had stem cell transplant following chemoradiation (n = 17) or only chemotherapy (n = 1). Following treatment, 10 patients achieved complete and 11 achieved partial responses.

Conclusion:
Orbital plasmacytomas were found exclusively in patients with MM diagnosed before or immediately after orbital plasmacytoma. Plasmacytomas can have 4 distinct anatomical patterns of origin. Following treatment, all patients had good to excellent local control of their orbital lesions.
Health Behaviors Survey
Authors: Serowoky Mary L. , Kwasky Andrea N. 
Published: June 2017

Abstract

Objective
This study determined the prevalence of alcohol, drug, and nonmedical prescription drugs at a small private university. In addition, risk and protective factors are examined.

Method
The Core Institute (Southern Illinois University) was contracted to administer an anonymous, Web-based 49-item survey to matriculated undergraduate students, aged 18–23 years. Data were obtained on student behaviors, perceptions, consequences of substance use, risk factors, and coping strategies. Statistical analysis included descriptive measures, cross-tabs, t test, and chi-square.

Results
The response rate was 14%, which is consistent with other CORE Institute surveys. Almost half of the total respondents were from the college of nursing (46%), and most participants were female (82%). There was a significant association between heavy drinking and grades; the B students engaged in more binge drinking. Living on campus and being involved in Greek life confer a higher level of risk for sexual assault when alcohol was consumed. Most participants (57%) were unaware of campus resources for assistance with alcohol or drug problems.

Conclusion
Campus administrators now have a better awareness related to the extent of drug and alcohol use among the student body. A faculty engagement workshop was developed to provide tools to assess and communicate with students. Improvements are anticipated to enhance student relationships and decrease incidents of drug- and alcohol-related sexual assault or misconduct.
Effectiveness of the Sexual Health/Reproductive Health Education Given to Turkey Adolescents Who Use Alcohol or Substance
Authors: Ataman Hacer , Kömürcü Nuran 
Published: June 2017

Abstract

Objective
The research was conducted experimentally to evaluate the effectiveness of the sexual health/reproductive health (SH/RH) education given to Turkish adolescents who use alcohol or illicit substances.

Methods
The population was adolescents who use alcohol and substances and were inpatients at the Child and Adolescent Substance Addiction Research, Treatment and Education Center. The adolescents were grouped into the following three groups: Group 1 (control group), Group 2 (those who have received training once), and Group 3 (those who have received training twice). Data were collected between September 2011 and December 2012 using the forms Self-Introduction and Information on Sexual Health-Reproductive Health and Information on Sexual Health-Reproductive Health Education Modules.

Results
Upon studying the total SH/RH test scores of the groups individually, a statistically significant difference was observed in the scores of Groups 2 and 3 (p < .01). Upon studying the change in the posttest scores from the pretest ones for each group individually, the increase in the scores of Group 3 (34.57 ± 16.33) was observed to have a statistically highly significant difference from those of Groups 1 (2.73 ± 10.65) and 2 (20.23 ± 12.09; p < .01).

Conclusions and Practice Implications
Adolescents who abuse alcohol or substances should be given SH/RH education in a repetitive manner for prevention of risky sexual behavior.
Oxytocin and potential benefits for obesity treatment
Authors: Olszewski Pawel K. , Klockars Anica , Levine Allen S. 
Published: June 2017

Purpose of review
Laboratory animal experiments have consistently shown that oxytocin causes early termination of food intake, thereby promoting a decrease in body weight in a long term. Recent studies have also assessed some of oxytocin's effects on appetite and energy balance in humans. The present study examines the findings of the key basic research and of the few clinical studies published thus far in the context of potential benefits and challenges stemming from the use of oxytocin in obese patients.

Recent findings
Basic research indicates the involvement of oxytocin in satiety, processing, in reducing a drive to eat for pleasure and because of psychosocial factors. Although the results of clinical studies are very scarce, they suggest that oxytocin administered intranasally in humans decreases energy-induced and reward-induced eating, supports cognitive control of food choices, and improves glucose homeostasis, and its effectiveness may be BMI dependent.

Summary
Despite the wealth of basic research showing broad anorexigenic effects of oxytocin, clinical studies on oxytocin's therapeutic potential in obesity, are still in their infancy. Future implementation of oxytocin-based pharmacological strategies in controlling energy balance will likely depend on our ability to integrate diverse behavioral and metabolic effects of oxytocin in obesity treatment regimens.
Novel imaging in advanced prostate cancer
Authors: Goldberg Hanan , Hamilton Robert J. 
Published: June 2017

Purpose of review
Prostate cancer (PCa) is the most commonly diagnosed noncutaneous cancer and second leading cause of death in men. Imaging evaluation of PCa is challenging because of the prostate's deep pelvic location, its complex zonal anatomy and its multifocal nature. Novel imaging modalities are needed to improve detection, reassessment in biochemical relapse, and disease progression in advanced metastatic stages.

Recent findings
Current imaging modalities have distinct strengths. However, all lack the ability to diagnose micrometastases, differentiate high from low-grade disease and diagnose advanced disease, especially at low prostate specific antigen values. There is a need to combine the existing imaging methods with concepts utilizing tumor biology to differentiate biologically aggressive from indolent tumors. PET imaging with novel tracers facilitate improved imaging of PCa, but also usher in new compounds that could be useful for directing treatment as well. Most tracers have limited sensitivity, with the exception of prostate-specific membrane antigen (PSMA)-targeting tracers, that offer relatively higher sensitivity and specificity.

Summary
PSMA-PET appears promising in improving the imaging yield particularly in recurrent and advanced disease states. Incorporating PSMA-PET in these settings could open or prolong windows along the trajectory of the disease that could allow new treatments or more effective use of currently existing treatments. Prospective studies focusing on novel imaging enhancement and integration with therapeutic applications are needed.
Reconstructing spatial transport distributions in the nuclear pore complex from 2D images—how reliable is it?
Authors: Tu Li-Chun , Huisman Maximiliaan , Chung Yu-Chieh , Smith Carlas , Grunwald David 
Published: June 2017

AbstractImaging single molecules in living cells and reconstituted cell systems has resulted in a new understanding of the dynamics of nuclear pore complex functions over the last decade. It does, however, fall short on providing insights into the functional relationships between the pore and nucleocytoplasmic cargo in three-dimensional space. This limited ability is the result of insufficient resolution of optical microscopes along the optical axis and limited fluorescent signal due to the short timescales involved in nuclear transport (fractions of a second). To bypass current technological limitations, it was suggested that highly time-resolved 2D single molecule data could be interpreted as projected cargo locations and could subsequently be transformed into a spatial cargo distribution by assuming cylindrical symmetry1. Such cargo distributions would provide valuable insights into the NPC-mediated transport in cells. This method, termed 3D-SPEED, has attracted large interest inside and beyond the nuclear pore field, but has also been sharply critiqued for a lack of critical evaluation. Here we present such an evaluation, testing the robustness, reconstruction quality and model-dependency.
Whole-ganglion imaging of voltage in the medicinal leech using a double-sided microscope
Authors: Tomina Yusuke , Wagenaar Daniel A. 
Published: June 2017

AbstractStudies of neuronal network emergence during sensory processing and motor control are greatly promoted by technologies that allow us to simultaneously record the membrane potential dynamics of a large population of neurons in single cell resolution. To achieve whole-brain recording with the ability to detect both small synaptic potentials and action potentials, we developed a voltage-sensitive dye (VSD) imaging technique based on a double-sided microscope that can image two sides of a nervous system simultaneously. We applied this system to the segmental ganglia of the medicinal leech. Double-sided VSD imaging enabled simultaneous recording of membrane potential events from almost all of the identifiable neurons. Using data obtained from double-sided VSD imaging we analyzed neuronal dynamics in both sensory processing and generation of behavior and constructed functional maps for identification of neurons contributing to these processes.