bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying effective initiators in OSNs: from the spectral radius perspective
Authors: Ma Songjun , Chen Ge , Wu Weijie , Song Li , Tian Xiaohua , Wang Xinbing 
Published: December 2016

AbstractIn this paper, we focus on maximizing the influence of online social networks (OSNs). Particularly, we try to answer how to select proper information initiators such that information can propagate as widely as possible. We stress our attention on the susceptible‐infected model, a type of epidemic models, to describe the process of information diffusion. In general, OSNs can be classified into two categories, Facebook‐like OSNs and Twitter‐like OSNs. The former ones require bidirectional connections, while the latter do not, so we use the undirected unweighted graph and directed unweighted graph to describe them, respectively. We also pay additional attention to the nonidentity of the link probability on information transmission and build the weight graph, which can also cover both the two types of OSNs. In order to determine values of weight graph's weights, we introduce a learning method to obtain useful factors from raw data for assessing the true link probability on information transmission. Based on spectral analysis within the three graphs, our investigations on the information diffusion show that the spectral radius of the graph adjacency matrix can reflect the capability of information propagation, according to which we could determine effective initiators. We conduct our simulations on real OSNs. Experimental results show that our approach could effectively discover the initiators that spread information widely. Copyright © 2016 John Wiley & Sons, Ltd.
Preparation of Highly Pure n‐3 PUFA‐Enriched Triacylglycerols by Two‐Step Enzymatic Reactions Combined with Molecular Distillation
Authors: Li Daoming , Wang Weifei , Li Xuehui , Durrani Rabia , Yang Bo , Wang Yonghua 
Published: December 2016

AbstractHighly pure n‐3 polyunsaturated fatty acids (PUFA)‐enriched triacylglycerols (TAG) have attracted considerable attention due to their nutritional benefits and pharmacological effects. In this study, an alternative approach to the conventional method for the synthesis of highly pure n‐3 PUFA‐enriched TAG by using a multi‐step process was reported. First, glyceride mixtures were synthesized through Novozym 435 [Novozymes A/S (Bagsvaerd, Denmark)] catalyzed esterification of n‐3 PUFA‐enriched FA and glycerol. Second, partial glycerides in the resulting glyceride mixtures were hydrolyzed to FA by immobilized partial glycerides‐selective lipase from Malassezia globosa. The purity of TAG reached 99.84% under the optimized conditions: buffer solution of pH 6.0, water content of 100% (w/w, with respect to the oil mass), enzyme loading of 120 U/g (U/w, with respect to oil mass) and reaction temperature of 30 °C. During hydrolysis, the immobilized SMG1‐F278N exhibited good reusability and TAG purity of over 94% was maintained after being used for six cycles. Subsequently, purification of TAG was accomplished by molecular distillation at low temperature (150 °C) and highly pure (99.85%) TAG with 88.73% n‐3 PUFA was obtained. The final glyceride mixtures with low acid, peroxide and anisidine value were promising products for medical and dietetic purposes. Compared with the conventional one‐step synthesis of n‐3 PUFA‐enriched TAG by enzymatic esterification or glycerolysis or the two‐step method by combined transesterification and ethanolysis, this improved process allows for higher purity of n‐3 PUFA‐enriched TAG and significant reduction in reaction time.
Variations in Magnetic Resonance Imaging Provision and Processes among Canadian Academic Centres
Authors: Vanderby Sonia , Badea Andreea , Peña Sánchez Juan Nicolás , Kalra Neil , Babyn Paul 
Published: December 2016

Purpose Increasing demand has led to questions regarding the appropriateness of advanced imaging exams, particularly for magnetic resonance imaging (MRI). The study aimed to explore variability in MRI service provision and request variation within Canadian academic medical imaging departments, particularly factors potentially affecting appropriate MRI service provision. Methods All Canadian academic centres with medical imaging residency programs were invited to participate. Participation involved completing an institution-level survey and submitting exam requests for all MRI exams completed in a common 24-hour period. The surveys and request forms were analysed and contrasted. Results The 13 participating institutions reported scanner operating hours per week ranging from 101-672; large urban centres typically had higher hours. A total of 42% of sites housed multiple scanners, and 28% housed a 3-T scanner. Most accept requests from all general practitioners and specialists. Only 1 institution has a solely electronic request submission process. Requisitions are focused on patient safety, including contrast considerations, metallic foreign bodies, and implants. Request prioritization scales vary substantially across institutions. Few use referral guidelines to evaluate request appropriateness. Conclusions Our analysis showed great variation among facility-level factors such as hours of operation, request forms, and prioritization scales among institutions and facilities. Opportunities exist to create standardized processes and improve request forms to focus more on specific information required for appropriateness, increase consistency in patient care, and promote demand balancing, minimizing unnecessary exams and therefore reducing wait times.
Exercise and its role in gestational diabetes mellitus
Authors: Wang Chen , Guelfi Kym Janese , Yang Hui‐Xia 
Published: December 2016

AbstractGestational diabetes mellitus (GDM) refers to diabetes diagnosed in the second or third trimester of pregnancy that is not clearly either type 1 or type 2 diabetes. GDM is a common medical complication in pregnancy that has been rapidly increasing worldwide. GDM is associated with both short‐ and long‐term health issues for both mothers and offspring. Consistent with type 2 diabetes, peripheral insulin resistance contributes to the hyperglycemia associated with GDM. Accordingly, it is important to identify strategies to reduce the insulin resistance associated with GDM. To date, observational studies have shown that exercise can be a non‐invasive therapeutic option for preventing and managing GDM that can be readily applied to the antenatal population. However, the relevant mechanisms for these outcomes are yet to be fully elucidated. The present review aimed to explain the potential mechanisms of exercise from the perspective of reducing the insulin resistance, which is the root cause of GDM. Exercise recommendations and opinions of exercise during pregnancy are briefly summarized.
Frequent exercise: A healthy habit or a behavioral addiction?
Authors: Chen Wan‐Jing 
Published: December 2016

AbstractIt is well known that regular physical activity helps improve overall health and fitness and reduces the risk of many chronic diseases. However, excessive exercise might be harmful. Exercise addiction (EA) is a pattern of uncontrolled exercise that involves a craving for overwhelming exercise with addictive attributes. So far, little is known about this unique behavioral addiction. The aim of the current study is to introduce the diagnosis and assessment of EA, and to summarize several developing theoretical models. Eating disorders, body image disorder, low self‐esteem, and high narcissism are related to high risk of EA. The paper also discusses the distinction between EA and highly involved physical activity.
Aboriginal Knowledges in Specialized Courts: Emerging Practices in Gladue Courts
Authors: Maurutto Paula , Hannah-Moffat Kelly 
Published: December 2016

AbstractReforms to Canadian sentencing law in 1996 and the Supreme Court of Canada decisionR. v. Gladue[1999] opened the door to a new normative set of legal practices that endeavour to integrate racial knowledge about offenders’ collective and individual experiences of race relations and oppression into traditional legal criminal practices. One outcome of the reforms and court cases was the formation of dedicated Gladue courts for Aboriginal peoples. This paper explores the formation of Gladue courts, the legal techniques used to produce contextualized racial knowledges, how this information is admitted as evidence before the court, and how this knowledge is used to reframe legal subjects and the risk they pose.
Storm Impact and Depression Among Older Adults Living in Hurricane Sandy–Affected Areas
Authors: Sirey Jo Anne , Berman Jacquelin , Halkett Ashley , Giunta Nancy , Kerrigan Janice , Raeifar Elmira , Artis Amanda , Banerjee Samprit , Raue Patrick J. 
Published: December 2016

AbstractObjectiveResearch on the impact of natural disasters on the mental health of older adults finds both vulnerabilities and resilience. We report on the rates of clinically significant depression among older adults (aged ≥60 years) living in areas affected by Hurricane Sandy in 2012 and the factors associated with mental health need.MethodsThe Sandy Mobilization, Assessment, Referral and Treatment for Mental Health (SMART-MH) program integrates community outreach and needs assessments to identify older adults with mental health and aging service needs. Older adults with significant anxiety or depressive symptoms were offered short-term psychotherapy. Social service referrals were made directly to community agencies. All SMART-MH activities were offered in Spanish, Russian, Mandarin/Cantonese, and English.ResultsAcross the full sample, 14% of participants screened positive for depression. Hurricane Sandy stressors predicted increased odds of depression, including storm injury, post-storm crime, and the total count of stressors. Outcomes varied significantly by age group, such that all Sandy-related variables remained significant for younger-old adults (aged 60–74 years), whereas only the loss of access to medical care was significant for older-old adults (aged ≥75 years).ConclusionsStorm-affected communities show higher rates of depressive symptoms than seen in the general population, with storm stressors affecting mental health needs differentially by age group. (Disaster Med Public Health Preparedness. 2017;11:97–109)
The impact of geographic range, sampling, ecology, and time on extinction risk in the volatile clade Graptoloida
Authors: Boyle James , Sheets H. David , Wu Shuang-Ye , Goldman Daniel , Melchin Michael J. , Cooper Roger A. , Sadler Peter M. , Mitchell Charles E. 
Published: December 2016

AbstractAlthough extinction risk has been found to have a consistent negative relationship with geographic range across wide temporal and taxonomic scales, the effect has been difficult to disentangle from factors such as sampling, ecological niche, or clade. In addition, studies of extinction risk have focused on benthic invertebrates with less work on planktic taxa. We employed a global set of 1114 planktic graptolite species from the Ordovician to lower Devonian to analyze the predictive power of species’ traits and abiotic factors on extinction risk, combining general linear models (GLMs), partial least-squares regression (PLSR), and permutation tests. Factors included measures of geographic range, sampling, and graptolite-specific factors such as clade, biofacies affiliation, shallow water tolerance, and age cohorts split at the base of the Katian and Rhuddanian stages.The percent variance in durations explained varied substantially between taxon subsets from 12% to 45%. Overall commonness, the correlated effects of geographic range and sampling, was the strongest, most consistent factor (12–30% variance explained), with clade and age cohort adding up to 18% and other factors <10%. Surprisingly, geographic range alone contributed little explanatory power (<5%). It is likely that this is a consequence of a nonlinear relationship between geographic range and extinction risk, wherein the largest reductions in extinction risk are gained from moderate expansion of small geographic ranges. Thus, even large differences in range size between graptolite species did not lead to a proportionate difference in extinction risk because of the large average ranges of these species. Finally, we emphasize that the common practice of determining the geographic range of taxa from the union of all occurrences over their duration poses a substantial risk of overestimating the geographic scope of the realized ecological niche and, thus, of further conflating sampling effects on observed duration with the biological effects of range size on extinction risk.
Fatty acid dietary intake in the general French population: are the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) national recommendations met?
Authors: Tressou Jessica , Moulin Philippe , Vergès Bruno , Le Guillou Céline , Simon Noémie , Pasteau Stéphane 
Published: December 2016

AbstractQuantity and quality of fatty acids (FA) in diet influence CVD risk. Consequently, health authorities promote recommended dietary intakes for FA, looking for optimal intakes in a primary prevention of CVD perspective. In parallel, a few data are available detailing intakes in national populations. The objective of the present study was to perform a large analysis combining the data of the French National Survey INCA 2 on food consumption performed in 2006 and 2007, and the nutritional content of food consumed in France updated in 2013 by the French Information Centre on Food Quality, to explore in details the FA intakes in French adults using the most recent available data. To compare the discrepancies in the observed intake levels with the French recommended levels, a weighted fat adherence score was built combining intakes of the different FA. Individual scores were computed in relation to official recommendations, and potential explanatory factors were identified. These data show that SFA intakes are persistently higher than national recommendations, combined with low intakes of MUFA and PUFA, particularly long-chain n-3 FA. Only 14·6 % of the French population met DHA intake recommendation, 7·8 % for EPA and 21·6 % for SFA. This situation remains unfavourable in terms of primary prevention of CVD. Consuming fish and other sources of n-3 FA, living in the south of France, being female, having a higher education level, and low alcohol consumption were associated with a healthier fat adherence score.
Producing the Climate: States, Scientists, and the Constitution of Global Governance Objects
Authors: Allan Bentley B. 
Published: December 2016

AbstractThis paper argues that the climate came to take on a geophysical rather than a bioecological form in global governance because it emerged from a dynamic, interactive process between states and scientists. In the 1950s, state agencies, especially elements of the US military, steered and accelerated the development of the geophysical sciences, which set the discursive frame within which climate politics now plays out. In the 1990s, scientists and IO experts responded to states' requests to study carbon sinks by expanding the climate to include new greenhouse gases and land-use practices. Drawing on Science and Technology Studies as well as discursive theories of global governance, I theorize object constitution as a process of co-production in which states steer the development of scientific knowledge and scientists assemble epistemic objects. This contingent interaction of political and scientific actors shapes the form and content of global governance objects. The argument extends and challenges the epistemic communities literature and theories of the global governance life cycle that focus on how problems end up on the agenda of states rather than the processes of problem construction.
Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation
Authors: Ismi O , Karabulut Y Y , Bal K K , Vayisoglu Y , Unal M 
Published: December 2016

AbstractObjective:Mesna (i.e. sodium 2-mercaptoethanesulfonate; C2H5NaO3S2) has been used in otological surgery such as cholesteatoma dissection and tympanic membrane lateralisation in atelectatic ears. However, this study aimed to investigate its effect on cholesteatoma formation.Methods:A total of 20 Wistar rats were divided into two groups of 10 animals. The right and left ears of control animals were treated with saline (saline control group; n = 10 ears) and propylene glycol plus saline (propylene glycol control group; n = 10 ears), respectively. In the mesna group, both ears were treated with propylene glycol plus mesna (n = 20 ears). On days 1, 8 and 15, the saline control group had intratympanic injections of 0.2 ml saline and the propylene glycol control and mesna groups had intratympanic injections of 0.2 ml 100 per cent propylene glycol. On day 22, the propylene glycol control group had a single intratympanic injection of 0.2 ml saline and the mesna group had a single intratympanic injection of 10 per cent mesna. Animals were killed 12 weeks after the last injection and the temporal bones were sent for histopathological evaluation.Results:The cholesteatoma formation rate was 88 per cent in the propylene glycol control group, but was significantly lower in the mesna group (p = 0.01). There were no significant differences in granulation tissue formation (p = 0.498), cyst formation in the bulla (p = 0.381), fibrosis (p = 0.072) and epithelial hyperplasia (p = 0.081) among experimental groups.Conclusion:Intratympanic propylene glycol administration is an effective method of promoting experimental cholesteatoma formation. Administration of a single dose of intratympanic mesna inhibited cholesteatoma formation in an animal model.
Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis
Authors: Pavlova B. , Perlis R. H. , Mantere O. , Sellgren C. M. , Isometsä E. , Mitchell P. B. , Alda M. , Uher R. 
Published: December 2016

BackgroundAnxiety disorders are highly prevalent in people with bipolar disorder, but it is not clear how many have anxiety disorders even at times when they are free of major mood episodes. We aimed to establish what proportion of euthymic individuals with bipolar disorder meet diagnostic criteria for anxiety disorders.MethodWe performed a random-effects meta-analysis of prevalence rates of current DSM-III- and DSM-IV-defined anxiety disorders (panic disorder, agoraphobia, social anxiety disorder, generalized anxiety disorder, specific phobia, obsessive–compulsive disorder, post-traumatic stress disorder, and anxiety disorder not otherwise specified) in euthymic adults with bipolar disorder in studies published by 31 December 2015.ResultsAcross 10 samples with 2120 individuals with bipolar disorder, 34.7% met diagnostic criteria for one or more anxiety disorders during euthymia [95% confidence interval (CI) 23.9–45.5%]. Direct comparison of 189 euthymic individuals with bipolar disorder and 17 109 population controls across three studies showed a 4.6-fold increase (risk ratio 4.60, 95% CI 2.37–8.92,p< 0.001) in prevalence of anxiety disorders in those with bipolar disorder.ConclusionsThese findings suggest that anxiety disorders are common in people with bipolar disorder even when their mood is adequately controlled. Euthymic people with bipolar disorder should be routinely assessed for anxiety disorders and anxiety-focused treatment should be initiated if indicated.
Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci
Authors: Liu M. , Malone S. M. , Vaidyanathan U. , Keller M. C. , Abecasis G. , McGue M. , Iacono W. G. , Vrieze S. I. 
Published: December 2016

BackgroundEndophenotypes are laboratory-based measures hypothesized to lie in the causal chain between genes and clinical disorder, and to serve as a more powerful way to identify genes associated with the disorder. One promise of endophenotypes is that they may assist in elucidating the neurobehavioral mechanisms by which an associated genetic polymorphism affects disorder risk in complex traits. We evaluated this promise by testing the extent to which variants discovered to be associated with schizophrenia through large-scale meta-analysis show associations with psychophysiological endophenotypes.MethodWe genome-wide genotyped and imputed 4905 individuals. Of these, 1837 were whole-genome-sequenced at 11× depth. In a community-based sample, we conducted targeted tests of variants within schizophrenia-associated loci, as well as genome-wide polygenic tests of association, with 17 psychophysiological endophenotypes including acoustic startle response and affective startle modulation, antisaccade, multiple frequencies of resting electroencephalogram (EEG), electrodermal activity and P300 event-related potential.ResultsUsing single variant tests and gene-based tests we found suggestive evidence for an association between contactin 4 (CNTN4) and antisaccade and P300. We were unable to find any other variant or gene within the 108 schizophrenia loci significantly associated with any of our 17 endophenotypes. Polygenic risk scores indexing genetic vulnerability to schizophrenia were not related to any of the psychophysiological endophenotypes after correction for multiple testing.ConclusionsThe results indicate significant difficulty in using psychophysiological endophenotypes to characterize the genetically influenced neurobehavioral mechanisms by which risk loci identified in genome-wide association studies affect disorder risk.
The predictors of persistent DSM-IV disorders in 3-year follow-ups of the British Child and Adolescent Mental Health Surveys 1999 and 2004
Authors: Ford T. , Macdiarmid F. , Russell A. E. , Racey D. , Goodman R. 
Published: December 2016

BackgroundThe identification of the factors that influence the persistence of psychiatric disorder may assist practitioners to focus on young people who are particularly prone to poor outcomes, but population-based samples of sufficient size are rare.MethodThis secondary analysis combined data from two large, population-based cross-sectional surveys in Great Britain (1999 and 2004) and their respective follow-ups (2002 and 2007), to study homotypic persistence among the 998 school-age children with psychiatric disorder at baseline. Psychiatric disorder was measured using the Development and Well-Being Assessment applying DSM-IV criteria. Factors relating to the child, family, and the severity and type of psychopathology at baseline were analysed using logistic regression.ResultsApproximately 50% of children with at least one psychiatric disorder were assigned the same diagnostic grouping at 3-year follow-up. Persistent attention-deficit/hyperactivity disorder and anxiety were predicted by poor peer relationship scores. Persistent conduct disorder was predicted by intellectual disability, rented housing, large family size, poor family function and by severer baseline psychopathology scores.ConclusionsHomotypic persistence was predicted by different factors for different groups of psychiatric disorders. Experimental research in clinical samples should explore whether these factors also influence response to interventions.