bluuebunny/crossref_metadata_2025_split huggingface dataset:
CDH11 inhibits proliferation and invasion in head and neck cancer
Authors: Piao Songlin , Inglehart Ronald C. , Scanlon Christina Springstead , Russo Nickole , Banerjee Rajat , D'Silva Nisha J. 
Published: July 2016

BackgroundIn this study, we use a bioinformatics‐based strategy to nominate a tumor suppressor gene cadherin‐11 (CDH11) and investigate its role in growth and invasion in head and neck squamous cell carcinoma (HNSCC).MethodsUsing the Oncomine™ database to compare HNSCC and normal specimens, CDH11 was nominated as having a role in HNSCC. CDH11 expression in HNSCC was evaluated by immunohistochemistry on a tissue microarray (TMA) and immunoblotting and immunofluorescence of cell lines. The functional impact of CDH11 on proliferation and invasion was evaluated after siRNA‐mediated knockdown.ResultsIn silico analysis suggested that CDH11 is overexpressed in HNSCC compared to normal specimens. HNSCC TMA exhibited a small but significant increase in intensity and proportion of CDH11. By immunoblot analysis, CDH11 was higher in 4/7 HNSCC cell lines compared to normal keratinocytes; CDH11 was highly upregulated in UM‐SCC‐47 and UM‐SCC‐74A and detectable in UM‐SCC‐14A and UM‐SCC‐29 cell lines. Downregulation of CDH11 in both UM‐SCC‐29 and UM‐SCC‐47 using two different siRNAs enhanced proliferation and invasion.ConclusionCDH11 inhibits cell proliferation and invasion of HNSCC. This suggests that CDH11 functions as a tumor suppressor gene in head and neck cancer. Our findings emphasize the importance of verifying in silico findings with functional studies.
Stochastic alternative splicing is prevalent in mungbean (Vigna radiata)
Authors: Satyawan Dani , Kim Moon Young , Lee Suk‐Ha 
Published: July 2016

SummaryAlternative splicing (AS) can produce multiple mature mRNAs from the same primary transcript, thereby generating diverse proteins and phenotypes from the same gene. To assess the prevalence of AS in mungbean (Vigna radiata), we analysed whole‐genome RNA sequencing data from root, leaf, flower and pod tissues and found that at least 37.9% of mungbean genes are subjected to AS. The number of AS transcripts exhibited a strong correlation with exon number and thus resembled a uniform probabilistic event rather than a specific regulatory function. The proportion of frameshift splicing was close to the expected frequency of random splicing. However, alternative donor and acceptor AS events tended to occur at multiples of three nucleotides (i.e. the codon length) from the main splice site. Genes with high exon number and expression level, which should have the most AS if splicing is purely stochastic, exhibited less AS, implying the existence of negative selection against excessive random AS. Functional AS is probably rare: a large proportion of AS isoforms exist at very low copy per cell on average or are expressed at much lower levels than default transcripts. Conserved AS was only detected in 629 genes (2.8% of all genes in the genome) when compared to Vigna angularis, and in 16 genes in more distant species like soya bean. These observations highlight the challenges of finding and cataloguing candidates for experimentally proven AS isoforms in a crop genome.
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5‐Year‐Old Child with Molluscum Contagiosum and Atopic Dermatitis
Authors: Cho Yong Se , Chung Bo Young , Park Chun Wook , Kim Hye One 
Published: July 2016

AbstractA eutectic mixture of lidocaine and prilocaine (EMLA) is used topically to provide local anesthesia for a variety of painful superficial procedures. Although the side effects of EMLA are usually mild and transient local reactions, potentially life‐threatening complications can occur. We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3.5‐year‐old girl with atopic dermatitis.
Probable Griseofulvin‐Induced Drug Reaction with Eosinophilia and Systemic Symptoms in a Child
Authors: Smith Robert J. , Boos Markus D. , McMahon Patrick 
Published: July 2016

AbstractA 9‐year‐old boy presented with fever, rash, anterior cervical lymphadenopathy, high liver enzymes, atypical lymphocytosis, and eosinophilia (drug reaction with eosinophilia and systemic symptoms [DRESS]). His history was notable for having taken griseofulvin for 3 weeks prior to onset of these findings. He improved after treatment with oral prednisone. We present a rare case of probable DRESS secondary to griseofulvin.
The invasive brown seaweed Sargassum muticum as new resource for alginate in Morocco: Spectroscopic and rheological characterization
Authors: El Atouani Samir , Bentiss Fouad , Reani Abdeltif , Zrid Rachid , Belattmania Zahira , Pereira Leonel , Mortadi Abdelhadi , Cherkaoui Omar , Sabour Brahim 
Published: July 2016

SUMMARYThe Japanese brown seaweed Sargassum muticum, recently invaded several shorelines worldwide including the Atlantic coast of Morocco with large well‐established populations. Within the framework of a sustainable strategy to control this invasive seaweed, we report on extraction yield, spectroscopic characterization and rheological properties of alginate, a commercially valuable colloid, from harvested biomass of S. muticum. Extraction yield was about 25.6% on dry weight basis. Infrared spectroscopy analysis shows that the obtained Fourier transform infrared spectra of the extracted biopolymer exhibit strong similarities with that of the commercial alginate. Furthermore, Proton nuclear magnetic resonance spectroscopy revealed that S. muticum alginate has almost equal amounts of β‐D‐mannuronic acid (M; 49%) and α‐L‐guluronic acid (G; 51%) with an M/G ratio of 1.04 and a high content of heteropolymeric MG GM diads suggesting a sequence distribution of an alternated polymer type. Rheological measurements were performed at different sodium alginate concentrations, temperatures and shear rates. The hydrocolloid exhibited pseudoplastic behavior and showed shear thinning, particularly at high solution concentration and low temperature which is consistent with the rheological behavior reported for commercial alginates. Considering the abundance of S. muticum in the Northwestern Atlantic coast of Morocco and the quality of the extracted hydrogel, this invasive species could be considered as a potential source of alginates.
Measuring EU Urban‐Rural Continuum Through Fuzzy Logic
Authors: Pagliacci Francesco 
Published: July 2016

AbstractThis paper aims to provide a multidimensional and continuous indicator of rurality by means of fuzzy logic. A nuanced urban‐rural continuum actually occurs in an enlarged Europe. Thus, the introduction of a fuzzy rurality indicator (FRI) can improve conventional urban‐rural classifications. FRI takes into account about 1,300 NUTS 3 regions throughout the EU 27. Being a continuous indicator, it highlights those nuances, in a multidimensional perspective: it covers complementary drivers, such as role of agriculture, population density and land use characteristics. The paper also stresses geographical differences among EU Countries and groups of them. In this respect, replacing Eurostat urban‐rural typologies, FRI improves both accuracy of further socio‐economic analyses and policy evaluations.
Computational design of reconfigurables
Authors: Garg Akash , Jacobson Alec , Grinspun Eitan 
Published: July 2016

A reconfigurable is an object or collection of objects whose transformation between various states defines its functionality or aesthetic appeal. For example, consider a mechanical assembly composed of interlocking pieces, a transforming folding bicycle, or a space-saving arrangement of apartment furniture. Unlike traditional computer-aided design of static objects, specialized tools are required to address problems unique to the computational design and revision of objects undergoing rigid transformations. Collisions and interpenetrations as objects transition from one configuration to another prevent the physical realization of a design. We present a software environment intended to support fluid interactive design of reconfigurables, featuring tools that identify, visualize, monitor and resolve infeasible configurations. We demonstrate the versatility of the environment on a number of examples spanning mechanical systems, urban dwelling, and interlocking puzzles, some of which we then realize via additive manufacturing.
Spatial-temporal information about collisions between objects is presented to the designer according to a cascading order of precedence. A designer may quickly determine when, and then where, and then how objects are colliding. This precedence guides the design and implementation of our four-dimensional spacetime bounding volume hierarchy for interactive-rate collision detection. On screen, the designer experiences a suite of interactive visualization and monitoring tools during editing: timeline notifications of new collisions, picture-in-picture windows for tracking collisions and suggestive hints for contact resolution. Contacts too tedious to remove manually can be eliminated automatically via our proposed constrained numerical optimization and swept-volume carving.
Climate Change in the Kola Peninsula, Arctic Russia, during the Last 50 Years from Meteorological Observations
Authors: Marshall Gareth J. , Vignols Rebecca M. , Rees W. G. 
Published: July 2016

AbstractThe authors provide a detailed climatology and evaluation of recent climate change in the Kola Peninsula, Arctic Russia, a region influenced by both the North Atlantic and Arctic Oceans. The analysis is based on 50 years of monthly surface air temperature (SAT), precipitation (PPN), and sea level pressure (SLP) data from 10 meteorological stations for 1966–2015. Regional mean annual SAT is ~0°C: the moderating effect of the ocean is such that coastal (inland) stations have a positive (negative) value. Examined mean annual PPN totals rise from ~430 mm in the northeast of the region to ~600 mm in the west. Annual SAT in the Kola Peninsula has increased by 2.3° ± 1.0°C over the past 50 years. Seasonally, statistically significant warming has taken place in spring and fall, although the largest trend has occurred in winter. Although there has been no significant change in annual PPN, spring has become significantly wetter and fall drier. The former is associated with the only significant seasonal SLP trend (decrease). A positive winter North Atlantic Oscillation (NAO) index is generally associated with a warmer and wetter Kola Peninsula whereas a positive Siberian high (SH) index has the opposite impact. The relationship between both the NAO and SH and the SAT is broadly coherent across the region whereas their relationship with PPN varies markedly, although none of the relationships is temporally invariant. Reduced sea ice in the Barents and White Seas and associated circulation changes are likely to be the principal drivers behind the observed changes.
Regression Mixture Model Clustering of Multimodel Ensemble Forecasts of Hurricane Sandy: Partition Characteristics
Authors: Kowaleski Alex M. , Evans Jenni L. 
Published: July 2016

AbstractTrack and cyclone phase space (CPS) forecasts of Hurricane Sandy from four global ensemble prediction systems are clustered using regression mixture models. Bayesian information criterion, cluster assignment strength, and mean-squared forecast error are used to select optimal model specifications. Fourth-order (third order) polynomials for 168-h forecasts (60-h forecast segments) and 5 (6) clusters for track (CPS) forecasts are selected.Mean cluster paths from eight initialization times show that track and CPS clustering meaningfully partition potential tracks and structural evolutions, distilling a large number of ensemble members into several representative and distinct solutions. Rand index and adjusted Rand index calculations demonstrate a relationship between track and CPS cluster membership for both 168-h forecasts and 60-h forecast segments, indicating that certain tracks are preferentially associated with certain structural evolutions. These relationships are explained in greater detail using forecasts initialized at 0000 UTC 25 October.Storm-centered cluster composite maps of 500-hPa geopotential height and 850-hPa equivalent potential temperature for the 120-h forecast valid at 0000 UTC 30 October (initialized at 0000 UTC 25 October) indicate that both track and CPS clustering successfully capture variations in the Sandy–trough interaction and the strength of the lower-troposphere warm core of Sandy at the time of observed landfall. Together, these results illustrate the relationship between the track and structural evolution of Sandy and suggest the potential of multiensemble mixture-model path clustering for tropical cyclone forecasting.
Pressure/flow modeling and induced seismicity resulting from two decades of high-pressure deep-well brine injection, Paradox Valley, Colorado
Authors: King Vanessa M. , Block Lisa V. , Wood Christopher K. 
Published: July 2016

The Bureau of Reclamation operates a deep injection well near Paradox Valley, Colorado. Intermittent injection testing began in 1991, followed by near-continuous injection since 1996. Daily average injection flow rates and surface injection pressures have been recorded since 1991, and seismicity has been monitored since 1985. Before the injection flow rate was decreased in 2013 in response to the largest induced earthquake to date, observed wellhead pressures were increasing and approaching the maximum permitted pressure. Potential solutions were needed to provide long-term reductions in wellhead pressures and to minimize the occurrence of future large-magnitude induced earthquakes. A key step in this process is to establish whether the trend of increasing pressures is more likely caused by far-field reservoir pressurization or near-well flow impairment. The spatiotemporal occurrence of induced seismicity is fit relatively well by a 1D diffusive triggering front relationship, suggesting that the reservoir can be modeled as a porous medium. Simple 1D, uncoupled porous models are therefore used to analyze the wellhead pressure response for the period of long-term injection. These simple models are found to provide a reasonable fit to the pressure/flow data. We did not observe the expected changes in the model parameters that would indicate significant near-well flow impairment, and thus we have concluded that the observed pressure increase is more likely related to far-field pressurization. Somewhat surprisingly, given the complex geologic structure and the heterogeneity in the locations of induced seismicity, the analysis demonstrates the ability of a simple radially symmetric porous model to fit the pressure/flow data in the near-well area (within approximately 2 km). Although the induced seismicity data suggest significant heterogeneity, the daily average wellhead pressure/flow data are insensitive to these features. In the absence of additional constraints, use of more complicated models is unlikely to produce substantial additional benefit for modeling in the near-well area.
Measuring Health-Related Quality of Life of Adults With Down Syndrome
Authors: Graves Rebecca Jermyn , Graff J. Carolyn , Esbensen Anna J. , Hathaway Donna K. , Wan Jim Y. , Wicks Mona Newsome 
Published: July 2016

Abstract
This study examined self- and caregiver-reported health-related quality of life (HRQOL) of 60 adults with Down syndrome (DS) using the QualityMetric Short Form-12 version 2 (SF-12v2). All HRQOL scores exceeded means and fell within one standard deviation of the SF-12v2 normative sample. Similarities between eight self- and caregiver-reported HRQOL scales were found with the exception of role physical scores (impact of health problems on typical accomplishments), which were lower when obtained by caregiver-report. A positive association was found between self- and caregiver-reported physical functioning scores (impact of health problems on physical activity). The SF-12v2 had high construct validity in this study. These findings support the feasibility of measuring HRQOL of adults with DS using self-report rather than reliance on caregiver-report.
Changes in the division of labor within highly educated German couples when the first child is born
Authors: Dechant Anna , Blossfeld Hans-Peter 
Published: July 2016

When becoming parents for the first time, German couples often adapt their division of paid and unpaid work, creating a more gender-specific allocation. Using longitudinal data from the qualitative event-centered project “Household division of domestic labor as a process”, we compare theoretically- postulated mechanisms of change in the division of work within couples with explanations given by the couples interviewed themselves. Our qualitative analysis demonstrates that economic and gender norm theories are quite successful at predicting changes towards a more traditional specialization when couples become parents for the first time, while they are less helpful in explaining the persistence of equal arrangements in the domestic division of work, or the change towards more equal arrangements. The interviews also show that the explanations which differentiate – within unpaid work – between childcare and housework are a better predictor of the realities of the arrangements. Furthermore, the causal order of the decisions suggested by the theories differs from the couples’ actual decision making processes: when facing the transition to parenthood, they decide first upon the division of childcare, and then of labor market activity and housework.
Zusammenfassung
Der Übergang zur Erstelternschaft und Veränderungen der innerfamilialen Arbeitsteilung bei hochgebildeten Paaren in Deutschland Wenn Paare in Deutschland Eltern werden, verändern sie häufig ihre Aufteilung von bezahlter und unbezahlter Arbeit in Richtung eines geschlechtsspezifischen Arrangements. Auf Basis von qualitativen, ereigniszentrierten Längsschnittdaten des Projektes “Innerfamiliale Arbeitsteilung als Prozess” vergleicht der vorliegende Artikel theoretische Annahmen zu Veränderungen der Arbeitsteilung in Paarbeziehungen mit den Erklärungen, die hochgebildete Paare selbst geben. Unsere qualitative Analyse zeigt, dass sowohl ökonomische als auch Gender-Theorien relativ erfolgreich erklären, warum Paare sich für eine eher traditionelle Spezialisierung der Arbeiten entscheiden, wenn sie den Übergang zur Erstelternschaft erleben. Diese Theorien sind hingegen weniger erfolgreich darin, zu erklären, warum Paare egalitäre Arrangements beibehalten oder wählen. Anhand der qualitativen Interviews wird ersichtlich, dass Erklärungsmuster, die im Bereich der unbezahlten Arbeit zwischen Kinderbetreuung und Hausarbeit unterscheiden, besser die Realität der Paare erfassen. Darüber hinaus ist die von den Theorien vorgeschlagene kausale Reihenfolge der Entscheidungen eine andere als die der Paare: im Übergang zur Elternschaft entscheiden werdende Eltern zunächst über die Kinderbetreuung und dann über Erwerbstätigkeit und Hausarbeit.
Investigation of hydrological time series using copulas for detecting
catchment characteristics and anthropogenic impacts
Authors: Sugimoto Takayuki , Bárdossy András , Pegram Geoffrey G. S. , Cullmann Johannes 
Published: July 2016

Abstract. Global climate change can have impacts on characteristics of rainfall–runoff events and subsequently on the hydrological regime. Meanwhile, the catchment itself changes due to anthropogenic influences. However, it is not easy to prove the link between the hydrology and the forcings. In this context, it might be meaningful to detect the temporal changes of catchments independent from climate change by investigating existing long-term discharge records. For this purpose, a new stochastic system based on copulas for time series analysis is introduced in this study.A statistical tool like copula has the advantage to scrutinize the dependence structure of the data and, thus, can be used to attribute the catchment behavior by focusing on the following aspects of the statistics defined in the copula domain: (1) copula asymmetry, which can capture the nonsymmetric property of discharge data, differs from one catchment to another due to the intrinsic nature of both runoff and catchment; and (2) copula distances can assist in identifying catchment change by revealing the variability and interdependency of dependence structures.These measures were calculated for 100 years of daily discharges for the Rhine River and these analyses detected epochs of change in the flow sequences. In a follow-up study, we compared the results of copula asymmetry and copula distance applied to two flow models: (i) antecedent precipitation index (API) and (ii) simulated discharge time series generated by a hydrological model. The results of copula-based analysis of hydrological time series seem to support the assumption that the Neckar catchment had started to change around 1976 and stayed unusual until 1990.
Asymmetric dual-gate-structured one-transistor dynamic random access memory cells for retention characteristics improvement
Authors: Kim Hyungjin , Lee Jong-Ho , Park Byung-Gook 
Published: July 2016

Abstract
One of the major concerns of one-transistor dynamic random access memory (1T-DRAM) is poor retention time. In this letter, a 1T-DRAM cell with two separated asymmetric gates was fabricated and evaluated to improve sensing margin and retention characteristics. It was observed that significantly enhanced sensing margin and retention time over 1 s were obtained using a negatively biased second gate and trapped electrons in the nitride layer because of increased hole capacity in the floating body. These findings indicate that the proposed device could serve as a promising candidate for overcoming retention issues of 1T-DRAM cells.
The Russian Antarctic Expedition under the command of Fabian Gottlieb von Bellingshausen and its reception in Russia and the world
Authors: Tammiksaar E. 
Published: July 2016

ABSTRACTThe existence of an icy continent around the South Pole is known to everybody today. But it is common to ascribe this kind of modern knowledge to navigators sailing in southern polar waters in the 19th century. A good illustration of this is the Russian Antarctic expedition (1819–1821) under the conduct of Fabian Gottlieb von Bellingshausen (Russian version Faddej Faddeevich Bellinsgauzen), the reception of which in Russian society of the 19th and 20th centuries is analysed in this article. During the cold war, beginning at the end of the 1940s, the question of who discovered Antarctica turned from being a scientific problem into a subject of political struggle between the United States of America, Great Britain and the Soviet Union. This article provides an analysis of the Russian discovery in the area, while at the same time, attempting to give an answer to the main question of the history of Antarctic exploration which is: is it well-justified to establish the first discoverer of Antarctica? All the dates in the text are according to the Gregorian calendar.