bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of dexamphetamine on the resting‐state electroencephalogram and functional connectivity
Authors: Albrecht Matthew A. , Roberts Gareth , Price Greg , Lee Joseph , Iyyalol Rajan , Martin‐Iverson Mathew T. 
Published: November 2015

AbstractThe catecholamines—dopamine and noradrenaline—play important roles in directing and guiding behavior. Disorders of these systems, particularly within the dopamine system, are associated with several severe and chronically disabling psychiatric and neurological disorders. We used the recently published group independent components analysis (ICA) procedure outlined by Chen et al. (2013) to present the first pharmaco‐EEG ICA analysis of the resting‐state EEG in healthy participants administered 0.45 mg/kg dexamphetamine. Twenty‐eight healthy participants between 18 and 41 were recruited. Bayesian nested‐domain models that explicitly account for spatial and functional relationships were used to contrast placebo and dexamphetamine on component spectral power and several connectivity metrics. Dexamphetamine led to reductions across delta, theta, and alpha spectral power bands that were predominantly localized to Frontal and Central regions. Beta 1 and beta 2 power were reduced by dexamphetamine at Frontal ICs, while beta 2 and gamma power was enhanced by dexamphetamine in posterior regions, including the parietal, occipital‐temporal, and occipital regions. Power–power coupling under dexamphetamine was similar for both states, resembling the eyes open condition under placebo. However, orthogonalized measures of power coupling and phase coupling did not show the same effect of dexamphetamine as power‐power coupling. We discuss the alterations of low‐ and high‐frequency EEG power in response to dexamphetamine within the context of disorders of dopamine regulation, in particular schizophrenia, as well as in the context of a recently hypothesized association between low‐frequency power and aspects of anhedonia. Hum Brain Mapp 37:570–588, 2016. © 2015 Wiley Periodicals, Inc.
Long‐term safety and activity of cladribine in patients with extranodal B‐cell marginal zone lymphoma of the mucosa‐associated lymphoid tissue (MALT) lymphoma
Authors: Kiesewetter Barbara , Dolak Werner , Simonitsch‐Klupp Ingrid , Mayerhoefer Marius E. , Raderer Markus 
Published: November 2015

AbstractThe purine analogue 2‐chloro‐deoxyadenosine (2‐CDA, cladribine) +/− rituximab has been successfully tested in mucosa‐associated lymphoid tissue lymphoma (MALT lymphoma) patients. However, studies using cladribine in other indications have reported the potential for prolonged hematological side effects and secondary hematologic and non‐hematologic malignancies. To date, there have been no data on long‐term effects of cladribine in MALT lymphoma patients. We have analyzed a large number of 49 patients treated with cladribine at our institution 1997–2011. All patients were treated within clinical trials and had undergone a standardized follow‐up protocol minimizing a potential bias in the detection of late sequels and relapses. After a median follow‐up time of 61 months (interquartile range: 43–72) for 49 analyzed patients, 35 (71%) are alive, while 14 (29%) have died. In the entire collective, three cases (6%) of prolonged pancytopenia including manifest myelodysplastic syndrome in one patient (2%), three cases (6%) of secondary lymphoid malignancies, and five cases (10%) of non‐hematologic cancers were documented. In terms of outcome, 42/49 (86%) patients responded to cladribine‐containing treatment, and only 10/42 (24%) responding patients needed further treatment after a median time to progression of 14 months (interquartile range, 8–34). Currently, 25/35 (71%) patients being alive are in ongoing complete remission and 2/35 (6%) in ongoing stable disease, respectively. Eight patients (23%) are free of lymphoma after second‐line therapy, with the median overall survival not having been reached. Our data suggest that cladribine might be safely applied in patients with MALT lymphoma, also in terms of long‐term toxicities. These data also confirm the potential of cladribine to induce durable remissions. Copyright © 2015 John Wiley & Sons, Ltd.
Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain‐Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells
Authors: Kashiwai Kei , Kajiya Mikihito , Matsuda Shinji , Ouhara Kazuhisa , Takeda Katsuhiro , Takata Takashi , Kitagawa Masae , Fujita Tsuyoshi , Shiba Hideki , Kurihara Hidemi 
Published: November 2015

ABSTRACTPreviously, we reported that brain‐derived neurotrophic factor (BDNF) enhances periodontal tissue regeneration by inducing periodontal ligament cell proliferation in vivo. In addition, the down growth of gingival epithelial cells, which comprises a major obstacle to the regeneration, was not observed. However, the underlying molecular mechanism is still unclear. Therefore, this study aimed to investigate the effect of BDNF on cell proliferation and apoptosis in human periodontal ligament (HPL) cells and human gingival epithelial cells (OBA9 cells) and to explore the molecular mechanism in vitro. HPL cells dominantly expressed a BDNF receptor, TrkB, and BDNF increased cell proliferation and ERK phosphorylation. However, its proliferative effect was diminished by a MEK1/2 inhibitor (U0126) and TrkB siRNA transfection. Otherwise, OBA9 cells showed a higher expression level of p75, which is a pan‐neurotrophin receptor, than that of HPL cells. BDNF facilitated not cell proliferation but cell apoptosis and JNK phosphorylation in OBA9 cells. A JNK inhibitor (SP600125) and p75 siRNA transfection attenuated the BDNF‐induced cell apoptosis. Moreover, OBA9 cells pretreated with SP600125 or p75 siRNA showed cell proliferation by BDNF stimulation, though it was reduced by U0126 and TrkB siRNA. Interestingly, overexpression of p75 in HPL cells upregulated cell apoptosis and JNK phosphorylation by BDNF treatment. These results indicated that TrkB‐ERK signaling regulates BDNF‐induced cell proliferation, whereas p75‐JNK signaling plays roles in cell apoptotic and cytostatic effect of BDNF. Overall, BDNF activates periodontal ligament cells proliferation and inhibits the gingival epithelial cells growth via the distinct pathway. J. Cell. Biochem. 117: 1543–1555, 2016. © 2015 Wiley Periodicals, Inc.
Docosahexaenoic acid inhibits inflammation via free fatty acid receptor FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK‐dependent Egr‐1 expression in EA.hy926 cells
Authors: Liu Kai‐Li , Yang Ya‐Chen , Yao Hsien‐Tsung , Chia Ting‐Wen , Lu Chia‐Yang , Li Chien‐Chun , Tsai Henry J , Lii Chong‐Kuei , Chen Haw‐Wen 
Published: November 2015

ScopeInflammation is intimately associated with many cardiovascular events and docosahexaenoic acid (DHA) has been shown to protect against CVD. Egr‐1 has emerged as a key regulator in the development of atherosclerosis. Free fatty acid receptor 4 (FFA4) is an n‐3 FA membrane receptor. Tumor necrosis factor alpha (TNF‐α) is an inflammatory mediator and transforming growth factor‐β‐activated kinase 1 (TAK1) is essential in the TNF‐α‐mediated activation of NF‐κB. We examined the mechanisms underlying DHA inhibition of inflammation in human EA.hy926 cells.Methods and resultsTNF‐α markedly induced the interaction between TAK1 binding protein (TAB) 2 and TAK1/TAB1, the phosphorylation of ERK, p38 MAPK and Akt, the expression of Egr‐1 and ICAM‐1, and HL‐60 (monocyte‐like) cell adhesion. Pretreatment with DHA attenuated TNF‐α‐induced phosphorylation of ERK, expression of Egr‐1 and ICAM‐1 and HL‐60 cell adhesion. Transfection with siFFA4 reversed the DHA‐mediated inhibition of TNF‐α‐induced Egr‐1 and ICAM‐1 expression, HL‐60 cell adhesion and NF‐κB and DNA‐binding activity.ConclusionOur results suggest that the anti‐inflammatory effect of DHA on the endothelium is at least partially linked to FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK‐dependent Egr‐1 and ICAM‐1 expression, which leads to less HL‐60 cell adhesion to TNF‐α‐stimulated EA.hy926 cells.
Thermodynamic parameters of Zr superconductor at – structural phase transition
Authors: Szczȩśniak R. , Durajski A. P. , Szczȩśniak D. 
Published: November 2015

AbstractAbstractauthoren In the present study, the thermodynamic parameters of the superconducting state in zirconium at the structural – phase transition (GPa) have been calculated. It has been shown that the jump of the critical temperature () from to 11K corresponds to the jump of the Coulomb pseudopotential from to . Other thermodynamic quantities, such as the order parameter at zero Kelvin (), the specific heat jump (), and the thermodynamic critical field () also undergo the abrupt change. The dimensionless parameters: , , and are equal to the following: , , and , respectively. Additionally, the structural phase transition induces the strong variation of the ratio of the electron effective mass to the electron band mass: . From the physical point of view, the increasing deviations of the superconducting parameters from the predictions of the BCS theory at the structural – phase transition have tight relation with the corresponding behavior of the electron–phonon coupling.
Short‐ and intermediate‐range order in amorphous GeTe
Authors: Stellhorn Jens R. , Hosokawa Shinya , Pilgrim Wolf‐Christian , Blanc Nils , Boudet Nathalie , Tajiri Hiroo , Kohara Shinji 
Published: November 2015

AbstractWe have investigated amorphous GeTe by anomalous X‐ray scattering coupled with reverse Monte Carlo modeling. Experiments were conducted at the two K‐absorption edges in order to determine differential structure factors for both elements. The results indicate that simple models like the bonding rule cannot accurately rationalize the atomic structure. Te atoms are found to be over‐coordinated with a mean coordination number of about 2.5. Moreover, evidence is given for a high level of intermediate‐range order based on Ge, which has not been reported previously. This order has a pronounced effect on the ring statistics observed in the amorphous network, and thereby on the phase‐change speed of GeTe.
A Rare Case of Male-to-Eunuch Gender Dysphoria
Authors: Hermann Maria , Thorstenson Andreas 
Published: November 2015

Abstract

Aim
The aim of this case report is to improve the awareness of this gender dysphoria both for the single patient interest as well as for the community.

Methods
This is a single-patient case report. Literature search and Internet browsing for forum concerning this subject were performed.

Conclusion
Healthcare professionals must be aware of this group of patients as they have a greater risk of self-harm in order to self-castrate, which could be acute and life threatening if not performed in the right way.
2D Coordination Polymer with a 1D Carboxylate‐Copper Chain Based on Rare Icosanuclear and Tetranuclear Clusters
Authors: Zhang Xue , Han Tong , Zou Qian , Zhu Rui‐Yu , Wang Jun‐Jie , Li Zuo‐Xi 
Published: November 2015

AbstractThe 2D coordination polymer {[Cu32(pa)24(μ2‐OH)8(μ3‐OH)8(bibp)8]·(CH3OH)3(H2O)5}∞ was prepared by the solvothermal reaction of Cu(NO3)2·3H2O with phthalic acid (H2pa) and 4, 4′‐bis(imidazol‐1‐yl)biphenyl (bibp). The CuII ions show five different kinds of coordination environments, which are all connected by the pa2– ion into an interesting 1D carboxylate‐copper chain with rare icosacopper and tetracopper clusters. The 1D chain is further bridged by the bibp ligand to form a 2D layer, which could be viewed as an unprecedented (4, 4) lattice based on rectangular and butterfly‐shaped tetracopper clusters with the ratio of 2:6. The magnetic properties were studied, and the results show antiferromagnetic interaction in the complicated 1D chain.
Simultaneous Rapid Saline Flush to Correct Catheter Malposition: A Clinical Overview
Authors: Natividad Elizabeth , Rowe Todd 
Published: November 2015

Abstract
Central venous catheters and peripherally inserted central catheters are fundamental in the delivery of pharmacologic and nutrition therapies to patient populations, including individuals with cancer. Malposition and migration of these catheters outside of the superior or inferior vena cava can contribute to delays in therapy as individuals await repositioning, and in some cases replacement of the catheter. Traditional repositioning using overwire or interventional radiology techniques can be costly and may delay care. The placement and management of these catheters has increasingly become the domain of specially trained vascular access nurses. A team of specially trained vascular access nurses, in collaboration with interventional radiologists at a National Cancer Institute-designated comprehensive cancer center developed a procedure for catheter repositioning using a simultaneous rapid saline flush technique (SRSFT). We present this procedure, along with implications for cost and clinical outcomes. Clinical outcomes suggest that 68% of catheters have been successfully repositioned using this technique with no adverse events associated with the procedure noted to date. In addition, the use of the SRSFT represents a cost savings of up to 90% compared with traditional repositioning procedures. The SRSFT is identified as safe, timely, cost-conscious, and therapeutically effective, although further research is needed to formally evaluate the efficacy of repositioning using this technique compared with overwire and interventional-radiology-guided repositioning, including complications and quality outcomes.
Improving Registered Nurses' Knowledge of Evidence-Based Practice Guidelines to Decrease the Incidence of Central Line-Associated Bloodstream Infections: An Educational Intervention
Authors: Humphrey Joy S. 
Published: November 2015

Abstract
Background: The 2011 Centers for Disease Control and Prevention guidelines provide evidence-based recommendations for preventing central line-associated bloodstream infection (CLABSI). Educating and training health care personnel—incorporating bundled strategies for maximizing patient safety throughout the course of intravenous therapy—is the major area of interest. Despite a low number of reported CLABSIs—below national benchmarks—our large regional medical center has the goal of 0 CLABSI.
Purpose: The purpose of our project was to develop an educational intervention guided by the Healthcare and Technology Synergy Framework to improve registered nurses' (RNs) knowledge of evidence-based practice guidelines to decrease the incidence of CLABSI.
Methodology: A pretest/posttest format was used to evaluate an educational session on the nursing management of central lines (CLs). Participants in the study were RNs employed at a large regional medical center who worked 50% or more per week providing direct patient care in the hospital's intensive care units. An educational session on nursing management of CLs was presented. A 16-question survey (7 demographic and 9 knowledge questions) to assess RNs' knowledge of care and maintenance of CLs was used as the pretest and posttest.
Conclusions: RNs' knowledge of care and maintenance of CLs improved significantly after the intervention (pretest mean score = 4.6 and posttest mean score = 8.4; P = .0001).
Implications for Practice: An educational intervention can increase RNs' knowledge of care of CLs. As a result of this project, an annual evidence-based practice educational intervention was adopted for RNs at our large regional medical center.
Effects of Exercise During Pregnancy on Maternal Heart Rate and Heart Rate Variability
Authors: May Linda E. , Knowlton Jennifer , Hanson Jessica , Suminski Richard , Paynter Christopher , Fang Xiangming , Gustafson Kathleen M. 
Published: November 2015

AbstractBackgroundPregnancy is associated with an increased sympathetic state, which can be exacerbated by gestational conditions. Research has shown that exercise during pregnancy lowers heart rate (HR) and can attenuate the symptoms of gestational conditions associated with increased sympathetic control. However, changes in maternal heart autonomic function in response to exercise have not been reported across multiple time points during pregnancy. This analysis is designed to address this gap.ObjectiveTo determine if exercise throughout gestation improves maternal cardiac autonomic nervous system functioning, as evidenced by decreased HR and increased heart rate variability (HRV) indices.DesignCase control study.SettingAcademic medical institution.ParticipantsA total of 56 women with healthy, singleton, low‐risk pregnancies.MethodsParticipants were asked to complete 3 resting 18‐minute HRV recordings at 28, 32, and 36 weeks' gestation, along with a physical activity questionnaire.Main Outcome MeasuresHRV indices were calculated for time (R peak to R peak interval standard deviation and root mean squared of successive differences) and frequency (very low, low, and high frequency) domain measures. The differences between groups were compared for HRV indices at 28, 32, and 36 weeks.ResultsResting HR was significantly lower in the exercise group at 28 weeks (P < .01) compared with the control group. The exercise group had significantly (P < .05) increased measures of resting HRV time domain measures at 28, 32, and 36 weeks' gestation compared with the control group. Resting HRV power was significantly increased (P < .05) in all frequency domain measures at 32 weeks in the exercise group relative to the control group. No differences occurred in sympathovagal balance (low frequency/high frequency ratio) between groups.ConclusionExercise throughout pregnancy can significantly improve cardiac autonomic control. More research is needed to determine if this adaptation to exercise may reduce the risk of adverse outcomes associated with gestational conditions with poor autonomic control, such as diabetes, hypertension, pre‐eclampsia, and excessive weight gain.
A Framework for Training Public Health Practitioners in Crisis Decision-Making
Authors: Kayman Harvey , Logar Tea 
Published: November 2015

AbstractThree sets of issues tend to be overlooked in public health emergency preparedness and response, which can be addressed with new training protocols. The first issue is procedural and concerns the often intuitive (as opposed to deliberative) nature of effective crisis decision-making. The second issue is substantive and pertains to the incorporation and prioritization of ethical, political, and logistical concerns in public health emergency guidelines. The third issue is affective and concerns human feelings and human frailty, which can derail the most well designed and best practiced procedural and substantive approaches to emergency response. This article offers an outline for a decision-making framework for public health emergencies that addresses and incorporates these issues within relevant guidelines and training. (Disaster Med Public Health Preparedness. 2016;10:165–173)
Patterning two-dimensional free-standing surfaces with mesoporous conducting polymers
Authors: Liu Shaohua , Gordiichuk Pavlo , Wu Zhong-Shuai , Liu Zhaoyang , Wei Wei , Wagner Manfred , Mohamed-Noriega Nasser , Wu Dongqing , Mai Yiyong , Herrmann Andreas , Müllen Klaus , Feng Xinliang 
Published: November 2015

AbstractThe ability to pattern functional moieties with well-defined architectures is highly important in material science, nanotechnology and bioengineering. Although two-dimensional surfaces can serve as attractive platforms, direct patterning them in solution with regular arrays remains a major challenge. Here we develop a versatile route to pattern two-dimensional free-standing surfaces in a controlled manner assisted by monomicelle close-packing assembly of block copolymers, which is unambiguously revealed by direct visual observation. This strategy allows for bottom-up patterning of polypyrrole and polyaniline with adjustable mesopores on various functional free-standing surfaces, including two-dimensional graphene, molybdenum sulfide, titania nanosheets and even on one-dimensional carbon nanotubes. As exemplified by graphene oxide-based mesoporous polypyrrole nanosheets, the unique sandwich structure with adjustable pore sizes (5–20 nm) and thickness (35–45 nm) as well as enlarged specific surface area (85 m2 g−1) provides excellent specific capacitance and rate performance for supercapacitors. Therefore, this approach will shed light on developing solution-based soft patterning of given interfaces towards bespoke functions.
A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development
Authors: Chen Qian , Liu Yang , Maere Steven , Lee Eunkyoung , Van Isterdael Gert , Xie Zidian , Xuan Wei , Lucas Jessica , Vassileva Valya , Kitakura Saeko , Marhavý Peter , Wabnik Krzysztof , Geldner Niko , Benková Eva , Le Jie , Fukaki Hidehiro , Grotewold Erich , Li Chuanyou , Friml Jiří , Sack Fred , Beeckman Tom , Vanneste Steffen 
Published: November 2015

AbstractMultiple plant developmental processes, such as lateral root development, depend on auxin distribution patterns that are in part generated by the PIN-formed family of auxin-efflux transporters. Here we propose that AUXIN RESPONSE FACTOR7 (ARF7) and the ARF7-regulated FOUR LIPS/MYB124 (FLP) transcription factors jointly form a coherent feed-forward motif that mediates the auxin-responsive PIN3 transcription in planta to steer the early steps of lateral root formation. This regulatory mechanism might endow the PIN3 circuitry with a temporal ‘memory’ of auxin stimuli, potentially maintaining and enhancing the robustness of the auxin flux directionality during lateral root development. The cooperative action between canonical auxin signalling and other transcription factors might constitute a general mechanism by which transcriptional auxin-sensitivity can be regulated at a tissue-specific level.
Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins
Authors: Kamps Jos J.A.G. , Huang Jiaxin , Poater Jordi , Xu Chao , Pieters Bas J.G.E. , Dong Aiping , Min Jinrong , Sherman Woody , Beuming Thijs , Matthias Bickelhaupt F. , Li Haitao , Mecinović Jasmin 
Published: November 2015

AbstractA large number of structurally diverse epigenetic reader proteins specifically recognize methylated lysine residues on histone proteins. Here we describe comparative thermodynamic, structural and computational studies on recognition of the positively charged natural trimethyllysine and its neutral analogues by reader proteins. This work provides experimental and theoretical evidence that reader proteins predominantly recognize trimethyllysine via a combination of favourable cation–πinteractions and the release of the high-energy water molecules that occupy the aromatic cage of reader proteins on the association with the trimethyllysine side chain. These results have implications in rational drug design by specifically targeting the aromatic cage of readers of trimethyllysine.