bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial Serological Response after Prime-boost Pneumococcal Vaccination in Rheumatoid Arthritis Patients: Results of a Randomized Controlled Trial
Authors: Nguyen Mai T.T. , Lindegaard Hanne , Hendricks Oliver , Jørgensen Charlotte Sværke , Kantsø Bjørn , Friis-Møller Nina 
Published: October 2017

Objective.To evaluate the initial serological responses to pneumococcal vaccination with the 13-valent protein-conjugated pneumococcal vaccine (PCV13) followed by the 23-valent polysaccharide pneumococcal vaccine (PPV23) among patients with rheumatoid arthritis (RA) treated with biological disease-modifying antirheumatic drugs (bDMARD) according to dosing and intervals between immunizations.Methods.Investigator-initiated clinical trial. Patients with RA receiving bDMARD were randomized (1:1:1) to immunization with single dose PCV13 followed by PPV23 after 16 or 24 weeks, or double dose PCV13 followed by PPV23 after 16 weeks. A comparison group of patients with RA treated with conventional synthetic (cs)DMARD received single dose PCV13 followed by PPV23 16 weeks later. Pneumococcal antibodies were collected before and 4 weeks after each vaccination. The primary endpoint was the proportion of participants responding to ≥ 6/12 pneumococcal serotypes 4 weeks after both vaccinations.Results.Sixty-five participants receiving bDMARD and 35 participants receiving csDMARD were included. After PPV23 vaccination, 87% (95% CI 0.76–0.94) and 94% (95% CI 0.77–0.99), respectively, of participants treated with bDMARD and csDMARD had reached the primary endpoint. There was no significant difference in primary endpoint between the 3 randomization arms. The response for rituximab-treated participants was 25% compared to ≥ 89% in participants treated with bDMARD with other mode of action.Conclusion.The early serological response to prime-boost vaccination with PCV13 followed by PPV23 was very similar among participants receiving bDMARD and csDMARD. However, notable differences in response were observed according to individual bDMARD. It is important to consider the RA treatment when planning pneumococcal vaccination in patients with RA.
Development of a Canadian Core Clinical Dataset to Support High-quality Care for Canadian Patients with Rheumatoid Arthritis
Authors: Barber Claire E.H. , Mosher Dianne P. , Ahluwalia Vandana , Zummer Michel , Marshall Deborah A. , Choquette Denis , Lacaille Diane , Bombardier Claire , Lyddiatt Anne , Chandran Vinod , Khodyakov Dmitry , Dao Emily , Barnabe Cheryl 
Published: October 2017

Objective.To develop a Canadian Rheumatoid Arthritis Core Clinical Dataset (CAN-RACCD) to standardize documentation encouraging high-quality care.Methods.A set of candidate elements was drafted through meetings with 27 rheumatologists, researchers, and patients, and supplemented with focused literature reviews. A 3-round online-modified Delphi consensus process was held with rheumatologists (n = 26), allied health professionals (n = 7), and patients (n = 4); for the remainder there was no demographic information. Participants rated both the importance and feasibility of documenting candidate elements on a Likert scale of 1–9, contributed to an online moderated discussion, and re-rated the elements for inclusion in the CAN-RACCD. Elements were included in the final set if importance and feasibility ratings had a median score of ≥ 6.5 and there was no disagreement among participants.Results.Fifty-five individual elements in 10 subgroups were proposed to the Delphi participants: measures of RA disease activity; dates to calculate waiting times, disease duration, and disease-modifying antirheumatic drug start; comorbidities; smoking status; patient-reported pain and fatigue; physical function; laboratory and radiographic investigations; medications; clinical characteristics; and vaccines. All groups were included in the final set, with the exception of vaccination status. Additionally, 3 individual elements from the smoking subgroup were eliminated with a recommendation to record smoking status as never/ever/current, and 2 elements relating to coping and effect of fatigue were eliminated due to low feasibility and importance ratings.Conclusion.The CAN-RACCD stands as a national recommendation on which data elements should be routinely collected in clinical practice to monitor and support high-quality RA care.
« I Hate Visual Culture »
Authors: Boidy Maxime 
Published: October 2017

L’essor des Visual Studies dans le monde académique étasunien durant les années 1990 s’inscrit dans le sillage de l’institutionnalisation des Cultural Studies outre-Atlantique. Il implique spécifiquement le décentrement de la discipline de l’histoire de l’art vers l’étude interdisciplinaire des visibilités socioculturelles. Cet article revient sur la montée en puissance de ces études dans un climat encore marqué par les « guerres culturelles » engagées par la droite néoconservatrice à l’encontre de certaines franges du champ universitaire et artistique au cours des années 1980. En abordant les conflits suscités par les Visual Studies au sein de la gauche intellectuelle comme un élément inhérent à leur définition savante, il analyse certaines politisations académiques des notions de « culture visuelle » et d’ « études visuelles » dans le contexte d’une importation et d’une redéfinition françaises actives de ces catégories.
Les recherches sur le jeu vidéo en France
Authors: Meunier Sarah 
Published: October 2017

Cet article présente le collectif français actuel de la recherche sur le jeu vidéo, en SHS, en questionnant son émergence dans le contexte des Game Studies. Il montre comment la formation de liens forts a favorisé celle-ci en France dans un contexte institutionnel peu favorable. Il s’appuie sur une série d’entretiens, sur un travail socio-historique à partir d’archives en ligne et privées, ainsi que sur un corpus de textes de référence sur le sujet. Ce travail fait ressortir trois éléments dans son déroulé. Il traite des enjeux de légitimation auxquels est soumis l’objet de recherche vidéoludique et qui impacte le développement des recherches. Il présente et analyse la formation d’un collectif de chercheur·e·s depuis vingt ans en portant attention à la nature des liens sociaux. Il interroge enfin la présence ou l’absence de liens entre les collectifs de recherche vidéoludique français et celui des Game Studies, en questionnant une éventuelle autonomie de la recherche française.
L’ethnographie et les mines
Authors: Lasevitz Rafael Simões 
Published: October 2017

À l’exception de quelques études éparpillées dans les années 1940 et 1950, on ne verra l’émergence d’un courant d’ « études minières » suffisamment cohérent qu’après le début des années 1970. Dans cet article, on propose de mieux comprendre la trajectoire de l’ethnologie dans le domaine et les idées qui l’ont informée. Le milieu minier étant souvent coincé entre les milieux ruraux et industriels, les études minières ont souvent rapproché l’ethnographie et les milieux industriels, jusque-là un domaine peu exploré par la discipline. La notion de culture est un concept clé dans les études de Harris, Nash ou Taussig, ce qui mènera entre autres à une perception de culture minière comme étant le résultat de la confrontation entre les cultures locales et les forces colonisatrices. Le syncrétisme culturel sera un thème récurrent et rassembleur dans les études minières jusqu’à ce que le besoin d’affronter le développementalisme fasse émerger l’approche post-développement dans les années 1980. Enfin, les années 2000 verront, dans un sens, un épuisement de ce modèle, menant à de nouvelles approches.
Les STS ont-elles un Sud ?
Authors: Dumoulin Kervran David , Kleiche-Dray Mina , Quet Mathieu 
Published: October 2017

Les études sociales sur les sciences (STS ou science studies), telles qu’elles se sont développées et institutionnalisées depuis les années 1980, ont constitué un pôle important du renouvellement des sciences sociales, toutefois resté longtemps indifférent aux travaux sur les sciences conduits dans les pays des Suds. La prise en compte de la diversité des perspectives qui sont développées sur/depuis les Suds permettrait pourtant de pousser plus loin la discussion entamée par les STS sur les savoirs, leurs sites et leur portée. Nous pensons en particulier que les approches postcoloniales fournissent des outils importants à la réflexion et donnent les moyens d’une « mondialisation » plus aboutie des STS, qui repose plus généralement sur une meilleure compréhension des apports des études sur les sciences dans les Suds. La proposition de l’article est développée en trois temps : 1) comprendre l’indifférence des études STS pour les recherches sur et dans les Suds, 2) analyser les processus qui ont permis les déplacements des STS aux Suds et 3) cartographier les défis posés par la « créolisation » des STS lorsque les critiques postcoloniales y sont pleinement intégrées.
Joey Adler : la vision d’un monde meilleur
Authors: Auger Claudine , Girard Martin 
Published: October 2017

Femme d’affaires accomplie et philanthrope acharnée, Joey Adler n’a l’esprit tranquille que si, chaque soir, elle a amélioré la vie d’au moins une personne. D’ailleurs, l’ex-PDG de Diesel Canada aime citer cet ancien proverbe chinois : un voyage de mille lieues commence toujours par un pas.
Industrie mondiale du tourisme : le vent dans les voiles !
Authors: Normandin François 
Published: October 2017

Derrière les plages de sable fin, les palmiers et les mers cristallines, l’industrie du tourisme a connu une croissance soutenue au cours des deux dernières décennies. La demande s’est diversifiée, tant au chapitre des pays visités qu’en ce qui concerne le type de tourisme recherché (éthique, culturel, religieux, etc.). En 2015, le secteur du tourisme a généré des revenus de 1,26 trillion $US et contribué à 10 % du PIB planétaire.
Les modèles d’innovation et leurs enjeux de gestion ouverte
Authors: Harvey Jean-François , Cromwell Johnathan R. 
Published: October 2017

Les termes « créativité » et « innovation » font maintenant partie du quotidien de la plupart des professionnels et des dirigeants. Ces concepts s’expriment habituellement par le truchement de deux modèles : centré-problème et centré-solution 1 . Quels défis de gestion accompagnent ces modèles, notamment lorsqu’il est question de collaborer au-delà des frontières organisationnelles, c’est-à-dire d’innover de façon ouverte ?
Influencer, c’est la communication d’aujourd’hui, de Stéphane Attal
Authors: Jézéquel Myriam 
Published: October 2017

« La communication a définitivement muté vers le partage plutôt que vers le message », affirme l’auteur Stéphane Attal, spécialiste de la communication d’influence. Encore faut-il savoir quoi partager et avec qui . Aussi important : comment mettre en scène et en débat une idée ?
La santé et le bien-être en milieu de travail : rentables et à la portée de toutes les entreprises
Authors: Durand Pierre , Marchand Alain 
Published: October 2017

Comment les entreprises, même de petite taille, peuvent-elles contribuer à l’amélioration de la santé mentale de leurs employés et, du même coup, réduire les demandes d’indemnisation auprès des compagnies d’assurances ? Voici des pistes, trop rentables pour qu’on n’en tienne pas compte.
Gérez-vous une équipe agile ou un lent paquebot ?
Authors: Bertholet Jean-François , Gaudet Marie-Claude 
Published: October 2017

Les organisations composent aujourd’hui avec des transformations à un rythme sans précédent. La gestion du changement est en soi ardue, mais un constat s’impose : le statu quo est impossible et l’agilité est une question de survie. Votre équipe se caractérise-t-elle par son agilité ? Faites le test !
Does corruption matter for the environment? Panel evidence from China
Authors: Liao Xianchun , Dogan Eyup , Baek Jungho 
Published: October 2017

Abstract
This article examines the income-energy-SO2 emissions nexus by taking a corruption variable into account. To that end, the panel cointegration methods are applied to 29 Chinese provinces over 1999–2012. The authors´ empirical evidence shows that an increase in the number of anti-corruption cases tends to drive down SO2 emissions in China. It is also found that income growth appears to have a beneficial effect on decreasing SO2 emissions over the past two decades. Finally, energy consumption is found to increase SO2 emissions.
New pediatric risk factors for amblyopia: strabismic versus refractive
Authors: Guimaraes Sandra , Vieira Maria , Queirós Tatiana , Soares Andreia , Costa Patrício , Silva Eduardo 
Published: October 2017

Purpose: To assess the role of risk factors for amblyopia, such as family history and neonatal background, for the prediction of either strabismic amblyopia or refractive amblyopia. Methods: In this retrospective case-control model, the study population included all children born at the Hospital de Braga during 1997-2012 (3 to 18 years old) with ophthalmologic consultation in 2014. Data collection was performed from the clinical database and through telephone questionnaire surveys. Results: A total of 298 (50%) controls and 298 (50%) cases (120 [40.3%] strabismic amblyopia and 178 [59.7%] refractive amblyopia) were analyzed. A significantly lower birthweight was detected in patients with strabismic amblyopia (mean 2,961 g [95% confidence interval (CI) 2,827-3,096]) compared to controls (mean 3,198 g [95% CI 3,125-3,271]) (p = 0.002). Five-minute Apgar was significantly lower in patients with strabismic amblyopia (mean 9.57 [95% CI 9.37-9.77]) than in controls (mean 9.83 [95% CI 9.77-9.90]) (p = 0.004) or patients with refractive amblyopia (mean 9.79 [95% CI 9.69-9.89]) (p = 0.031). Family history of either amblyopia or strabismus was associated with amblyopia (χ2 [2, n = 562] = 12.66; p = 0.002; Cramer V = 0.150; χ2 [2, n = 561] = 11.0; p = 0.004; Cramer V = 0.140), but was significantly more associated with strabismic amblyopia (p = 0.0023 and p = 0.0032) than with refractive amblyopia (p = 0.48 and p = 0.015, respectively). Multinomial logistic regression model explained 50.8% of the variance in amblyopia development. Low 5-minute Apgar had a relevant odds ratio (OR) for either strabismic amblyopia (OR 3.44; p = 0.066) or refractive amblyopia (OR 3.30; p = 0.077). Conclusions: This division in amblyopia subtypes gives a new perspective of the risk factors for amblyopia, with family history and some obstetrician/neonatal outcomes appearing to be more relevant in strabismic amblyopia. Educating health care providers to recognize these risk factors can result in an early ophthalmologic referral.
Aflibercept in the management of acute retinal necrosis syndrome-related macular edema
Authors: Ortega-Evangelio Leticia , Navarrete-Sanchis Javier , Williams Basil K. , Tomás-Torrent Juan Miguel 
Published: October 2017

Purpose: Acute retinal necrosis (ARN) is a panuveitis syndrome that may lead to severe complications such as cystoid macular edema (CME). There is no consensus about the best treatment. We report one case of CME secondary to ARN managed with intravitreal aflibercept. Case report: A 41-year-old woman with a history of successfully treated varicella-zoster virus-associated ARN developed an epiretinal membrane (ERM) and underwent pars plana vitrectomy, ERM removal, inner limiting membrane peel, and lensectomy. After surgery, the retinal architecture improved and the visual acuity returned to 20/20. Six months later, she developed nontractional CME, which was treated monthly with triple-dose intravitreal aflibercept (2 mg). She gained 3 lines of vision and CME resolution was achieved. Discussion: Cystoid macular edema is a late complication of ARN that may affect vision. Some off-label therapies have been reported to be useful in CME secondary to ARN, including pegaptanib and interferon-α-2. Since interferon-α-2a is not currently available for ophthalmic use in Spain, aflibercept was the first choice. This soluble protein blocks the placental growth factor and all isoforms of vascular endothelial growth factor (VEGF); its half-life is prolonged and its affinity to VEGF-A is more than 100-fold greater than bevacizumab, pegaptanib, or ranibizumab. After each injection, macular thickness decreased consistently and visual acuity improved 3 lines after the treatment. Conclusions: Intravitreal aflibercept is effective in the management of acute nontractional CME secondary to ARN.
Intestinal mucosal barrier dysfunction in SAP patients with MODS ameliorated by continuous blood purification
Authors: Shen Qing , Li Zhengrong , Huang Shanshan , Li Liman , Gan Hua , Du Xiao-Gang 
Published: October 2017

Background: Dysfunction of the intestinal mucosal barrier plays an important role in the pathophysiology of severe acute pancreatitis (SAP). Continuous blood purification (CBP) has been shown to improve the prognosis of SAP patients. In order to investigate the effect of CBP on intestinal mucosal barrier dysfunction in SAP patients with MODS, we conducted in vivo and in vitro experiments to explore the underlying mechanisms. Methods: The markers for the assessment of intestinal mucosal barrier function including serum diamine oxidase (DAO), endotoxin and intestinal epithelial monolayer permeability were detected during CBP therapy. The distribution and expression of cytoskeleton protein F-actin and tight junction proteins claudin-1 were observed. In addition, Rho kinase (ROCK) mRNA expression and serum tumor necrosis factor-alpha (TNF-α) levels during CBP were determined. Results: SAP patients with MODS had increased levels of serum DAO, endotoxin and intestinal epithelial monolayer permeability when compared with normal controls. While the distribution of F-actin and claudin-1 was rearranged, and the expression of claudin-1 significantly decreased, but F-actin had no change. Meanwhile, ROCK mRNA expression and serum TNF-α level were increased. However, after CBP treatment, levels of serum DAO, endotoxin and intestinal epithelial monolayer permeability decreased. The F-actin and claudin-1 reorganization attenuated and the expression of claudin-1 increased. At the same time, ROCK mRNA expression and serum TNF-α level were decreased. Conclusions: CBP can effectively improve intestinal mucosal barrier dysfunction. The beneficial effect is associated with the improvement of cytoskeleton and tight junction proteins in stability by downregulation of ROCK mRNA expression through the removal of excess proinflammatory factors.
The effect of ultrasonically activated irrigation and laser based root canal irrigation methods on debris removal
Authors: Kamaci Aysenur , Aydin Berdan , Erdilek Necdet 
Published: October 2017

Purpose: To test the efficacy of debris removal of 5 in vitro irrigation protocols: conventional irrigation, irrigation activated by ultrasound, Er:YAG laser with photon-induced photoacoustic streaming (PIPS) tip, and 2 diode laser techniques. Methods: The root canals of 75 extracted human canine teeth were enlarged and bisected longitudinally. Standardized grooves were prepared 2-6 mm from the root apex and filled with 0.5 mm of dentine debris. The teeth were reassembled and irrigated using 1 of the following techniques (n = 15/technique): (1) conventional irrigation, (2) diode laser irrigation - tip placed 2 mm from working length, (3) diode laser irrigation - tip placed at root canal orifice, (4) Er:YAG laser - PIPS, and (5) ultrasonically activated irrigation. The root segments were disassembled, and the amount of remaining debris was evaluated by 3 examiners under a stereomicroscope at ×20 magnification using a 4-grade scoring system. The data were statistically analyzed using Kruskal-Wallis and Dunn’s multiple comparison tests, with a 95% confidence level (p = 0.05). Cohen’s kappa test was used to evaluate inter-observer and intra-observer agreement. Results: Ultrasonically activated irrigation removed significantly more dentinal debris than conventional irrigation (p = 0.016), but there were no significant differences between the other groups. Conclusions: Ultrasonically activated irrigation was more effective than conventional irrigation in the removal of apically placed dentine debris.
Long Noncoding RNAZEB1-AS1 Expression Predicts Progression and Poor Prognosis of Colorectal Cancer
Authors: Fu Jining , Cui Yongyuan 
Published: October 2017

Background ZEB1-AS1 acts as an oncogene in hepatocellular carcinoma, accelerating tumor growth and promoting metastasis. However, its roles in colorectal cancer (CRC) remain unclear. Methods In this study, we determined the expression of ZEB1-AS1 in CRC tissues by quantitative real-time polymerase chain reaction (qRT-PCR). Additionally, we investigated the relationship between various clinicopathological features of CRC patients and ZEB1-AS1 expression, and evaluated the diagnostic and prognostic value of ZEB1-AS1 in CRC. Results We found that ZEB1-AS1 expression was significantly higher in CRC tissues than in adjacent normal colorectal tissues. Moreover, its expression was significantly correlated with tumor size, differentiation degree, TNM grade, metastasis, depth of invasion and Dukes' classification, but not with sex, age, location and organization. In addition, at the optimal cutoff value of 2.340, the values of diagnostic sensitivity and specificity amounted to 63.0% and 90.7%, respectively, with an area under the curve (AUC) of 0.846 (95% CI, 0.797-0.895). Finally, CRC patients of the high ZEB1-AS1 expression group had a poorer prognosis and a significantly lower survival rate than those of the low expression group, and Cox regression analysis indicated that ZEB1-AS1 expression and metastasis were independent predictors of poor prognosis. Conclusions Our data suggest that ZEB1-AS1 has no obvious early diagnostic value, but it may be utilized as a new prognostic biomarker for CRC.
Clinical implications for pro-GRP in small cell lung cancer. A single center experience
Authors: Cavalieri Stefano , Morelli Daniele , Martinetti Antonia , Galli Giulia , Nichetti Federico , de Braud Filippo , Platania Marco 
Published: October 2017

Background: Recently, pro-gastrin-releasing peptide (pro-GRP) became available as an alternative sensitive, specific and reliable tumor marker for patients with small cell lung cancer (SCLC), both in limited (LD) and diffuse disease (DD). Methods: We retrospectively analyzed pro-GRP, neuron-specific enolase (NSE) and CEA in patients with SCLC and non-small cell lung cancer (NSCLC). Serum pro-GRP level was measured with electrochemiluminescence at our laboratory (cutoff 77.8 pg/mL). Continuous variables were analyzed with the Mann-Whitney test, contingency data with Fisher’s exact test. Receiver operator characteristic (ROC) curve analysis was performed to identify threshold values to set the highest sensitivity (Sn) and specificity (Sp) values. Results: A total of 65 patients were studied (49 men, median age 67 years, range 27-79). Thirty-seven patients had SCLC (29 DD, 8 LD) and 28 advanced NSCLC. Median pro-GRP level was 919 pg/mL (range 22-147,350) in SCLC and 32 pg/mL (range 10-119.2) in NSCLC (p<0.0001). NSE was 4.38-fold higher in SCLC patients (p = 0.0005); CEA did not reveal significant differences between groups. Pro-GRP Sn and Sp were 86.4% and 96.4%, respectively. With ROC curve analysis, a cutoff value of 329.3 pg/mL showed a Sn of 75.8% and Sp of 87.5% in discriminating DD from LD. Pro-GRP was not influenced by either liver metastases or renal impairment. Conclusions: Pro-GRP is sensitive for SCLC diagnosis. Since high marker levels are related to high disease burden, pro-GRP may have a negative prognostic significance. Follow-up studies are required to define its role in clinical practice in monitoring responses to treatment and early relapses.