bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report: deep and durable response to low-dose lenvatinib and tislelizumab in an elderly patient with advanced intrahepatic cholangiocarcinoma
Authors: Zhang Pei , Wang Xin , Li Ruizhen , Li Xiaoying , Cheng Ke , Cao Dan 
Published: September 2024

BackgroundOlder patients with advanced cholangiocarcinoma lack systemic therapy standards. These people have a high risk of chemotherapy, accompanied by adverse reactions and even discontinuation of treatment.Case presentationWe report a 78-year-old female subject with advanced intrahepatic cholangiocarcinoma presenting with unresectable lesions involving the hepatic veins, along with extensive metastatic lymph nodes. After the geriatric assessment, capecitabine was utilized for only one cycle owing to adverse events (AEs). Next, a combination of low-dose lenvatinib and tislelizumab was administrated as a second-line treatment, which resulted in remarkable early tumor shrinkage. The following individual lenvatinib taper enabled a manageable safety profile and durable deep response. A near-complete response was achieved, with the primary tumor significantly reducing from 5.6 cm × 4.7 cm to nearly complete disappearance, accompanied by complete regression of lymph nodes, and both progression-free survival and overall survival exceeding 24 months.ConclusionThe case provides valuable insights that could influence future treatment strategies for older patients with advanced cholangiocarcinoma who are unsuitable for chemotherapy. The dose-individualized chemotherapy-free regime of lenvatinib and tislelizumab might be used in similar cases to improve their outcomes.
Case report: Advances in treating ligyrophobia with third-generation ACT approach
Authors: Marino Flavia , Doria Germana , LoPresti Adele , Gismondo Stefania , Failla Chiara , Pioggia Giovanni 
Published: September 2024

Background and aimsGiulia, an 11-year-old girl diagnosed with ligyrophobia, has been experiencing intense anxiety related to loud noises since the age of two. This case report aims to explore the efficacy of Third-Wave Cognitive Behavioral Therapy, specifically Acceptance and Commitment Therapy (ACT), in addressing Giulia’s anxiety and avoidance behaviors. The primary goal is to examine the impact of ACT on reducing ligyrophobic symptoms and enhancing psychological flexibility.MethodsThe therapeutic intervention spanned 24 sessions and was divided into two phases. The initial phase focused on emotional competence using characters from the movie “Inside Out,” aiding Giulia in recognizing and understanding her emotions. The subsequent phase targeted the six processes of psychological inflexibility identified in ACT, fostering increased flexibility.ResultsThroughout the intervention, Giulia demonstrated significant improvements in anxiety symptoms, as evidenced by a decrease in Subjective Units of Distress (SUD) scores. Avoidance behaviors also diminished, and Giulia exhibited enhanced mindfulness skills. She became more cognizant of her emotional experiences and more certain of her personal ideals as a result of the therapy. Giulia’s active participation and commitment to exposure exercises led to a substantial reduction in ligyrophobic reactions.DiscussionThe successful application of ACT in Giulia’s case suggests that targeting psychological inflexibility through mindfulness and values clarification can be effective in treating ligyrophobia in children. The integration of metaphors and creative exercises proved valuable in engaging Giulia and fostering therapeutic progress. The findings underscore the importance of a tailored, third-wave therapeutic approach in addressing specific phobias in pediatric populations.
Cognitive Orientation to daily Occupational Performance (CO-OP) for mood, anxiety, and adjustment disorders: a pilot study
Authors: Wong Su Ren , Chan Mu Rong , Chong Edlina , Dancza Karina Michelle 
Published: September 2024

IntroductionGlobal mental health issues, particularly anxiety and depression, significantly impact people’s everyday activities. While psychotherapies are commonly used, there is a growing interest in problem-solving approaches within mental health. These approaches focus on enabling individuals to develop personalized strategies to address emotional and psychological challenges and enhance their engagement in meaningful activities, known as occupational performance. This paper examines the feasibility of the Cognitive Orientation to daily Occupational Performance (CO-OP) in assisting adults with mood, anxiety, or adjustment disorders.MethodThe study employed a mixed methods single-subject design with replication, using an inductive/deductive approach for qualitative analysis. Ethical approval was obtained, and participants were recruited from a Singaporean hospital’s occupational therapy service. CO-OP sessions were conducted either in-person or via telehealth. The intervention involved setting goals collaboratively, followed by weekly sessions over 10 weeks. Various data sources, including demographics, field notes, recordings of sessions, assessments and interviews were collected. Data analysis involved comparing pre- and post-intervention scores, thematic analysis of interviews, and triangulation of quantitative and qualitative data for validity. The study results are organized according to five feasibility domains: acceptability, demand, implementation, practicality, and limited efficacy.ResultsA total of 10 participants, mostly female, were recruited, with two dropping out during the baseline phase. All remaining participants completed the intervention and 1 month follow-up data collection. CO-OP was perceived as acceptable and beneficial in enhancing occupational performance, satisfaction and managing mood and anxiety symptoms. Participants expressed increased confidence and self-efficacy but desired continued therapist support for strategy application and reinforcement.DiscussionParticipants generally embraced CO-OP, favoring its personalized nature over therapist-directed approaches, with high retention rates observed. Building a strong therapeutic relationship was essential. Also using complementary approaches like supportive counseling proved beneficial. CO-OP emerges as a viable intervention alongside existing therapy approaches, offering a promising avenue for addressing the complex needs of individuals with mental health conditions.
A hybrid MCDM approach based on combined weighting method, cloud model and COPRAS for assessing road construction workers’ safety climate
Authors: Cai Jing , Hu Yihui , Peng Yiming , Guo Fengxiang , Xiong Jian , Zhang Ran 
Published: September 2024

PurposeThe purpose of this paper is to propose a novel approach to assess the safety climate level of different groups of workers in a construction company and predict safety performance and implement targeted improvement measures.Design/methodology/approachThis paper utilizes the BP neural network and random forest algorithm to establish a weight learning mechanism for calculating the weights of safety climate evaluation criteria. The cloud model is employed to construct the decision matrix for different groups under the evaluation criteria. Meanwhile, the paper utilizes the COPRAS method to compare the safety climate of different groups.FindingsThe findings show the accuracy of the CM-COPRAS model is assessed by comparing it with the other methods. The three models are almost consistent in assessing the safety climate for working age groups, accident experience groups, and work type groups, with slight differences in the evaluation results for the education groups. The consistency of the computational results of the CM-COPRAS model with the results of the existing research, i.e., that the education level is positively proportional to the safety climate supports the reasonableness and validity of the CM-COPRAS model.OriginalityThe paper proposes a hybrid MCDM method that integrates the Combined weighting method, Cloud model, and COPRAS for safety climate level evaluation in different construction worker groups. A case study is presented to demonstrate the applicability of the proposed method and to compare it with other methods to validate the effectiveness of the present method.
Esculetin Combats Multidrug-Resistant Salmonella Infection and Ameliorates Intestinal Dysfunction via the Nrf2 Pathway
Authors: Xu Wenjiao , Ding Wenjun , Jia Liyan , Zhu Kui , Luo Qingfeng 
Published: September 2024

The increasing incidence of multidrug-resistant (MDR) Salmonella enterica serovar Typhimurium (S. Tm), known for causing invasive enteric infections, presents a significant public health challenge. Given the diminishing efficacy of existing antibiotics, it is imperative to explore novel alternatives for the treatment of MDR S. Tm infections. Here, we identified esculetin (EST), a natural coumarin abundant in dietary foods and herbs, as a compound exhibiting broad-spectrum antibacterial properties against a range of MDR bacteria. Our findings demonstrate that EST effectively inhibited the proliferation and expansion of MDR S. Tm in both in vitro experiments and animal models. Specifically, EST significantly downregulated the type 3 secretion system-1 (T3SS-1) virulence expression of MDR S. Tm, thereby preventing its invasion into intestinal epithelial cells. In S. Tm-infected mice, we observed cecal injury characterized by the upregulation of inflammatory cytokines, a reduction in goblet cell numbers, a decreased expression of tight junction proteins, and microbial dysbiosis. Conversely, EST treatment ameliorated these pathological changes induced by S. Tm infection and reduced oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, thereby improving intestinal barrier function. These results suggest that dietary coumarins or a targeted plant-based diet may offer a promising strategy to counteract MDR bacteria-induced enteric diseases.
Preparation and Biochemical Activity of Copper-Coated Cellulose Nonwoven Fabric via Magnetron Sputtering and Alginate-Calcium Ion Complexation
Authors: Świerczyńska Małgorzata , Mrozińska Zdzisława , Juszczak Michał , Woźniak Katarzyna , Kudzin Marcin H. 
Published: September 2024

Alginate-based materials have gained significant recognition in the medical industry due to their favorable biochemical properties. As a continuation of our previous studies, we have introduced a new composite consisting of cellulose nonwoven fabric charged with a metallic copper core (CNW-Cu0) covered with a calcium alginate (ALG−Ca2+) layer. The preparation process for these materials involved three main steps: coating the cellulose nonwoven fabric with copper via magnetron sputtering (CNW → CNW-Cu0), subsequent deposition with sodium alginate (CNW-Cu0 → CNW-Cu0/ALG−Na+), followed by cross-linking the alginate chains with calcium ions (CNW-Cu0/ALG−Na+ → CNW-Cu0/ALG−Ca2+). The primary objective of the work was to supply these composites with such biological attributes as antibacterial and hemostatic activity. Namely, equipping the antibacterial materials (copper action on representative Gram-positive and Gram-negative bacteria and fungal strains) with induction of blood plasma clotting processes (activated partial thromboplastin time (aPTT) and prothrombin time (PT)). We determined the effect of CNW-Cu0/ALG−Ca2+ materials on the viability of Peripheral blood mononuclear (PBM) cells. Moreover, we studied the interactions of CNW-Cu0/ALG−Ca2+ materials with DNA using the relaxation plasmid assay. However, results showed CNW-Cu0/ALG−Ca2+’s cytotoxic properties against PBM cells in a time-dependent manner. Furthermore, the CNW-Cu0/ALG−Ca2+ composite exhibited the potential to interact directly with DNA. The results demonstrated that the CNW-Cu0/ALG−Ca2+ composites synthesized show promising potential for wound dressing applications.
Selective Elimination of Genetic Variants of Human Embryonic Stem Cells from High Vulnerability to Ferroptosis
Authors: Kim Yun-Jeong , Kim Seon Min , Go Young-Hyun , Kim Han Sun , Park Sunghyouk , Kang Yun Pyo , Cha Hyuk-Jin 
Published: September 2024

Despite the great promise of human pluripotent stem cell (hPSC)-based cell therapy, safety concerns arise from genetic aberrations during in vitro culture, due to their uncertain consequences. Notably, these genetic aberrations confer a survival trait known as “culture-adaptation”, allowing aberrant hPSCs to evade apoptosis and outcompete normal cells. Thus, it is crucial to develop strategies for selectively eliminating aberrant hPSCs to ensure the safety of therapeutic applications. Herein, we discovered that hPSCs with genetic variations exhibited increased glycolysis and active fatty acid biosynthesis. Surprisingly, these variants, showing resistance to stress-induced apoptosis, were paradoxically susceptible to ferroptosis by the treatment of RAS-selective lethal 3 (RSL3), a glutathione peroxide 4 inhibitor. The selective sensitivity to RSL3 resulted from elevated levels of polyunsaturated fatty acids containing phospholipids, driven by the up-regulation of acyl-coenzyme A synthetase long-chain family member 4 through Yes1-associated protein 1 activity. Importantly, the distinct sensitivity of normal hPSCs and metabolic variants to ferroptosis enabled the targeted removal of genetically aberrant hPSCs through RSL3 treatment, while normal hPSCs transiently exposed to RSL3 maintained their pluripotency and normal differentiation capacity. These findings hold important promise for the maintenance of genetically normal hPSCs during extended in vitro culture, thereby ensuring the safety and efficacy of hPSC-based cell therapies.
Copper-Based Nanomedicines for Cuproptosis-Mediated Effective Cancer Treatment
Authors: Noh Dahye , Lee Hokyung , Lee Sangmin , Sun In-Cheol , Yoon Hong Yeol 
Published: September 2024

The recent discovery of cuproptosis, a novel copper-ion-induced cell death pathway, has suggested the novel therapeutic potential for treating heterogeneous and drug-resistant cancers. Currently, copper ionophore-based therapeutics have been designed to treat cancers, utilizing copper ions as a strategic tool to impede tumor proliferation and promote cellular demise. However, limitations of copper ionophore-based therapies include nontargeted delivery of copper ions, low tumor accumulation, and short half-life. Strategies to enhance specificity involve targeting intracellular cuproptosis mechanisms using nanotechnology-based drugs. Additionally, the importance of exploring combination therapies cannot be overstated, as they are a key strategy in improving the efficacy of cancer treatments. Recent studies have reported the anticancer effects of nanomedicines that can induce cuproptosis of cancer both in vitro and in vivo. These cuproptosis-targeted nanomedicines could improve delivery efficiency with the pharmacokinetic properties of copper ion, resulting in increasing cuproptosis-based anticancer effects. This review will summarize the intricate nexus between copper ion and carcinogenesis, examining the pivotal roles of copper homeostasis and its dysregulation in cancer progression and fatality. Furthermore, we will introduce the latest advances in cuproptosis-targeted nanomedicines for cancer treatment. Finally, the challenges in cuproptosis-based nanomedicines will be discussed for future development directions.
Measurement and Analysis of Noise Levels from Loudspeakers on Public Transportation in Kupang, East Nusa Tenggara
Authors: Wellem Theophilus , Nataliani Yessica , Manongga Danny , Hendry Hendry , Utomo Darmawan , Timotius Ivanna K. , Kameo Daniel D. , Lasso Aldi , Weku Winsy C.D 
Published: September 2024

The government is very concerned about the threshold value of human hearing that causes permanent noise-induced hearing loss (NIHL), such as noise caused by public transportation (bemo) in Kupang. This research aims to increase the awareness of the bemo user in Kupang to prevent hearing loss due to noise from bemo audio devices. Noise measurements due to public transportation are usually carried out outside the vehicle, for example, on the street, but in this study, measurements were carried out inside the vehicle (bemo). Data was obtained from (1) Data on sound intensity in public transport taken manually using a Sound Pressure Level (SPL) meter and (2) Data on the working hours of the drivers taken manually by asking how long they drive in a day. The results of of each route and the average of of eight routes showed a sound intensity above the threshold set by the government, i.e., 70 dB. Routes 1 and 3 are bemo routes that need attention because they have maximum sound intensity of more than 100 dB and are included in the Very Loud category. Meanwhile, the other routes are included in the Loud category. Furthermore, the average time a driver stays in a bemo daily is 13.5 hours, which concluded that all drivers are at risk of hearing loss. Therefore, special attention is needed from the government because this can result in driver hearing loss.
Keywords: Bemo; Kupang; Noise-induced hearing loss; Public transportation; Sound intensity
ASUHAN KEBIDANAN KOMPREHENSIF PADA NY. H DI WILAYAH KERJA PUSKESMAS KUIN RAYA KECAMATAN BANJARMASIN BARAT
Authors: Nur Cahyani Ari Lestari  , Adinda Raudita  , Muflihah  
Published: September 2024

PWS-KIA recapitulation data at the Kuin Raya Health Center in 2020 total coverage of pure K1 is 356 people (93.9%), K4 352 people (92.8%). Delivery by health workers 349 with (96.4%). Postpartum services were 419 people (76.3%). KN1 as many as 551 infants (100%) and complete KN as many as 448 infants (81.3%).Research method used in the preparation of the final report is descriptive research with case study method. The research was conducted at Sungai Jingah Health Center Banjarmasin Barat, and took place from October 2020 - January 2021. The subject used in this case study with midwifery care management was Mrs. H G2P0A0 35 weeks pregnant which was given comprehensively from pregnancy, childbirth, postpartum, newborn and family planning in the Kuin Raya Health Center Banjarmasin Work Area. On the results of the Final Project Report (LTA) with Comprehensive Midwifery Care carried out from pregnancy, childbirth, postpartum, newborn and family: Subjective and objective data on care for pregnancy, childbirth, newborns, postpartum and family planning on Ny. H has been collected. Subjective and objective data on the care of pregnancy, childbirth, newborns, postpartum and family planning on Ny. H has been interpreted. Based on subjective and objective data on care of pregnancy, childbirth, newborns, postpartum and family planning on Ny. H can be drawn assessment or diagnosis in all care is physiological. Based on the data analysis, there is no need for immediate action for collaboration and referral to care for pregnancy, childbirth, newborns, postpartum and family planning in Ny. H.
A Multiwavelength Study to Decipher the 2017 Flare of the Blazar OJ 287
Authors: Acharyya A. , Adams C. B. , Archer A. , Bangale P. , Bartkoske J. T. , Batista P. , Benbow W. , Brill A. , Caldwell J. P. , Carini M. , Christiansen J. L. , Chromey A. J. , Errando M. , Falcone A. , Feng Q. , Finley J. P. , Foote J. , Fortson L. , Furniss A. , Gallagher G. , Hanlon W. , Hanna D. , Hervet O. , Hinrichs C. E. , Hoang J. , Holder J. , Humensky T. B. , Jin W. , Johnson M. N. , Kaaret P. , Kertzman M. , Kherlakian M. , Kieda D. , Kleiner T. K. , Korzoun N. , Krennrich F. , Kumar S. , Lang M. J. , Lundy M. , Maier G. , McGrath C. E , Millard M. J. , Millis J. , Mooney C. L. , Moriarty P. , Mukherjee R. , O’Brien S. , Ong R. A. , Pohl M. , Pueschel E. , Quinn J. , Rabinowitz P. L. , Ragan K. , Reynolds P. T. , Ribeiro D. , Roache E. , Ryan J. L. , Sadeh I. , Sadun A. C. , Saha L. , Santander M. , Sembroski G. H. , Shahinyan K. , Shang R. , Splettstoesser M. , Tak D. , Talluri A. K. , Tucci J. V. , Williams D. A. , Wong S. L. ,   (VERITAS Collaboration), Jorstad S. G. , Lico R. , Lusen P. , Marscher A. P. 
Published: September 2024

Abstract
In 2017 February, the blazar OJ 287 underwent a period of intense multiwavelength activity. It reached a new historic peak in the soft X-ray (0.3–10 keV) band, as measured by the Swift X-ray Telescope. This event coincides with a very-high-energy (VHE) γ-ray outburst that led VERITAS to detect emission above 100 GeV, with a detection significance of 10σ (from 2016 December 9 to 2017 March 31). The time-averaged VHE γ-ray spectrum was consistent with a soft power law (Γ = −3.81 ± 0.26) and an integral flux corresponding to ∼2.4% that of the Crab Nebula above the same energy. Contemporaneous data from multiple instruments across the electromagnetic spectrum reveal a complex flaring behavior, primarily in the soft X-ray and VHE bands. To investigate the possible origin of such an event, our study focuses on three distinct activity states: before, during, and after the 2017 February peak. The spectral energy distributions during these periods suggest the presence of at least two nonthermal emission zones, with the more compact one responsible for the observed flare. Broadband modeling results and observations of a new radio knot in the jet of OJ 287 in 2017 are consistent with a flare originating from a strong recollimation shock outside the radio core.
A Radio-loud Semiregular Variable
Authors: Luque-Escamilla Pedro L. , Martí Josep 
Published: September 2024

Abstract
As a byproduct of our search for Galactic stellar systems with gamma-ray emission, we have identified an unrelated cool and evolved star (IRC-10412) that attracted our attention due to its strong radio emission level with a spectral index matching, almost perfectly, the canonical +0.6 value expected from an ionized stellar wind. A follow-up observational analysis was undertaken given that these two properties are hard to reconcile as originating in the same stellar object. As a result, IRC-10412 has been classified as a new semiregular variable of SRb type in the asymptotic giant branch, and different but consistent estimates of its mass-loss parameter are reported. We propose that its unusually high radio emission arises from a ∼10−5
M
⊙ yr−1 stellar wind exposed to an external source of ionizing photons, possibly coming from nearby OB associations.