bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Pharmacist Counseling on the Success of Therapy and the Quality of Life of Hypertensive Patients in a Hospital in East Nusa Tenggara
Authors: Riwu Magdarita , Yubiliana Gilang , Halimah Eli , Lestari Keri , Suwantika Auliya , Perwitasari Dyah , Diantini Ajeng 
Published: November 2017

AbstractHypertension is a chronic disease that requires an intensive monitoring from time to time to prevent complications leading to cardiovascular disease. In addition, its complex health needs have an effect on the treatment process and the motivation of the patient for treatment. Therefore, pharmacist counseling is expected to provide information to patients in handling health problems, especially related to the treatment of hypertension. Counseling is expected to provide behavioral changes to optimize therapeutic effects and improve the quality of life of patients. The purpose of this study is to analyze the influence of pharmacist counseling on the success of therapy and quality of life of hypertensive patients. The study was conducted at a hospital in Kupang, East Nusa Tenggara to outpatients in Depo Induk implementing true experimental design and pretest posttest with control group with simple random sampling method during April - June 2017. The data collection included blood pressure, age, gender, education level, treatment success seen from decreased or controlled blood pressure, and quality of life with Short Form- 36 (SF-36). The subjects of the study were 100 people divided into 50 people in the non-counseling group (who merely received information on medication as usual by pharmacist in Depo Induk) and 50 people in the counseling group (who received drug information service as usual by pharmacist in Depo Induk and individual counseling by pharmacist/researcher). Counseling was given in the form of giving insight about drugs, hypertension, and non-pharmacological approach (lifestyle modification) in managing hypertension. The results showed that with counseling, pharmacists can improve treatment success proven by the decrease of systolic blood pressure (-9 mmHg, p=0,000) and diastolic blood pressure (-7 mmHg, p=0,000); improve the quality of life of hypertensive patients with p<0.000 value of both pre and posttest and treatment (counseling) and also validated by final data test results between non-counseling group and counseling group.
Culturally Responsive Mathematics Teaching and Constructivism: Preparing Teachers for Diverse Classrooms
Authors: Wachira Patrick , Mburu Jane 
Published: November 2017

Abstract
As the school population becomes increasingly diverse with students of differing ethnic, cultural and linguistic backgrounds, there is a need for more responsive practices that capitalize on the cultural capital that such students bring to the learning process. Current practices especially in mathematics teaching are failing to meet the learning needs of most diverse students thus contributing to their lack of success. Further, few teacher education programs have successfully tackled the challenging task of preparing teachers to meet the learning needs of diverse students. This article explores the theory of constructivism and its implications to mathematics teaching. The article further explores culturally responsive pedagogy and what it means to be a culturally responsive teacher. In their analyses, the authors draw parallels between culturally responsive pedagogical practices and strategies for teaching based on a constructivist view of learning. They demonstrate why the general principles derived from the constructivist theory are particularly suited for teaching diverse students consistent with notions of culturally responsive pedagogy. Some recommendations for teacher preparation are then provided.
Metameric Light Sources: A Recent Paradigm for Functional Lighting
Authors: Petrulis Andrius , Vitta Pranciškus , Aglinskaitė Justina , Vaicekauskas Rimantas , Žukauskas Artūras 
Published: November 2017

AbstractRecent progress in tuneable solid-state light sources opens new opportunities in a niche and high added value lighting applications. The standard colorimetric technique of composing an identical colour coordinate metameric light spectra are facing the challenges due to the colour discrepancy noticed by the observers. A side-by-side colour matching experiment was performed with two tuneable tetrachromatic RAGB lamps (638 nm red, 598 nm pc amber, 518 nm green, 451 nm blue LEDs) to compare the colour of the metameres in a 10-deg viewing angle. The metameric light matching was investigated using a 2-deg (CIE 1931) and 10-deg (CIE 1964) XYZ colour matching function. Both colour matching functions of standard colorimetric observers were shown to be inaccurate for aligning of metameric spectral power distributions without a noticeable difference in a perceived colour. On the other hand, a wide scatter of individual results revealed that the standard colour matching functions are inherently limited and in some cases, especially in professional lighting applications, the individually adjustable metameric lighting approach is to be considered.
Scattering of Non-Relativistic Charged Particles by Electromagnetic Radiation
Authors: Apostol M. 
Published: November 2017

Abstract
The cross-section is computed for non-relativistic charged particles (like electrons and ions) scattered by electromagnetic radiation confined to a finite region (like the focal region of optical laser beams). The cross-section exhibits maxima at scattering angles given by the energy and momentum conservation in multi-photon absorption or emission processes. For convenience, a potential scattering is included and a comparison is made with the well-known Kroll-Watson scattering formula. The scattering process addressed in this paper is distinct from the process dealt with in previous studies, where the scattering is immersed in the radiation field.
Mesalazine-induced myopericarditis in a patient with ulcerative colitis
Authors: Asadi Jalal , Bhandari Sanjay S. , Ahmed Nauman 
Published: November 2017

Summary
A 25-year-old male with a background of ulcerative colitis presented with a two-week history of central chest pain. His ECG on presentation showed global T wave inversion with a peak troponin I of 165 ng/mL. Clinical diagnosis of myopericarditis/myocarditis was made. Echocardiography and cardiac magnetic resonance (MR) confirmed the diagnosis. On detailed assessment of his medication history, mesalazine was suspected as an etiological factor, with discontinuation resulting in an improvement in symptoms, inflammatory markers and cardiac enzymes. This is a unique case of mesalazine-induced myopericarditis on a background of inflammatory bowel disease.
Natural Variation inSER1andENA6Underlie Condition-Specific Growth Defects inSaccharomyces cerevisiae
Authors: Sirr Amy , Scott Adrian C , Cromie Gareth A , Ludlow Catherine L , Ahyong Vida , Morgan Trey S , Gilbert Teresa , Dudley Aimée M 
Published: November 2017

AbstractDespite their ubiquitous use in laboratory strains, naturally occurring loss-of-function mutations in genes encoding core metabolic enzymes are relatively rare in wild isolates of Saccharomyces cerevisiae. Here, we identify a naturally occurring serine auxotrophy in a sake brewing strain from Japan. Through a cross with a honey wine (white tecc) brewing strain from Ethiopia, we map the minimal medium growth defect to SER1, which encodes 3-phosphoserine aminotransferase and is orthologous to the human disease gene, PSAT1. To investigate the impact of this polymorphism under conditions of abundant external nutrients, we examine growth in rich medium alone or with additional stresses, including the drugs caffeine and rapamycin and relatively high concentrations of copper, salt, and ethanol. Consistent with studies that found widespread effects of different auxotrophies on RNA expression patterns in rich media, we find that the SER1 loss-of-function allele dominates the quantitative trait locus (QTL) landscape under many of these conditions, with a notable exacerbation of the effect in the presence of rapamycin and caffeine. We also identify a major-effect QTL associated with growth on salt that maps to the gene encoding the sodium exporter, ENA6. We demonstrate that the salt phenotype is largely driven by variation in the ENA6 promoter, which harbors a deletion that removes binding sites for the Mig1 and Nrg1 transcriptional repressors. Thus, our results identify natural variation associated with both coding and regulatory regions of the genome that underlie strong growth phenotypes.
Two Distinct Regulatory Mechanisms of Transcriptional Initiation in Response to Nutrient Signaling
Authors: Ferdoush Jannatul , Sen Rwik , Kaja Amala , Barman Priyanka , Bhaumik Sukesh R 
Published: November 2017

Abstract
SAGA (Spt-Ada-Gcn5-Acetyltransferase) and TFIID (transcription factor IID) have been previously shown to facilitate the formation of the PIC (pre-initiation complex) at the promoters of two distinct sets of genes. Here, we demonstrate that TFIID and SAGA differentially participate in the stimulation of PIC formation (and hence transcriptional initiation) at the promoter of PHO84, a gene for the high-affinity inorganic phosphate (Pi) transporter for crucial cellular functions, in response to nutrient signaling. We show that transcriptional initiation of PHO84 occurs predominantly in a TFIID-dependent manner in the absence of Pi in the growth medium. Such TFIID dependency is mediated via the NuA4 (nucleosome acetyltransferase of H4) histone acetyltransferase (HAT). Intriguingly, transcriptional initiation of PHO84 also occurs in the presence of Pi in the growth medium, predominantly via the SAGA complex, but independently of NuA4 HAT. Thus, Pi in the growth medium switches transcriptional initiation of PHO84 from NuA4-TFIID to SAGA dependency. Further, we find that both NuA4-TFIID- and SAGA-dependent transcriptional initiations of PHO84 are facilitated by the 19S proteasome subcomplex or regulatory particle (RP) via enhanced recruitment of the coactivators SAGA and NuA4 HAT, which promote TFIID-independent and -dependent PIC formation for transcriptional initiation, respectively. NuA4 HAT does not regulate activator binding to PHO84, but rather facilitates PIC formation for transcriptional initiation in the absence of Pi in the growth medium. On the other hand, SAGA promotes activator recruitment to PHO84 for transcriptional initiation in the growth medium containing Pi. Collectively, our results demonstrate two distinct stimulatory pathways for PIC formation (and hence transcriptional initiation) at PHO84 by TFIID, SAGA, NuA4, and 19S RP in the presence and absence of an essential nutrient, Pi, in the growth media, thus providing new regulatory mechanisms of transcriptional initiation in response to nutrient signaling.
Local Fitness Landscapes Predict Yeast Evolutionary Dynamics in Directionally Changing Environments
Authors: Gorter Florien A , Aarts Mark G M , Zwaan Bas J , de Visser J Arjan G M 
Published: November 2017

Abstract
The fitness landscape is a concept that is widely used for understanding and predicting evolutionary adaptation. The topography of the fitness landscape depends critically on the environment, with potentially far-reaching consequences for evolution under changing conditions. However, few studies have assessed directly how empirical fitness landscapes change across conditions, or validated the predicted consequences of such change. We previously evolved replicate yeast populations in the presence of either gradually increasing, or constant high, concentrations of the heavy metals cadmium (Cd), nickel (Ni), and zinc (Zn), and analyzed their phenotypic and genomic changes. Here, we reconstructed the local fitness landscapes underlying adaptation to each metal by deleting all repeatedly mutated genes both by themselves and in combination. Fitness assays revealed that the height, and/or shape, of each local fitness landscape changed considerably across metal concentrations, with distinct qualitative differences between unconditionally (Cd) and conditionally toxic metals (Ni and Zn). This change in topography had particularly crucial consequences in the case of Ni, where a substantial part of the individual mutational fitness effects changed in sign across concentrations. Based on the Ni landscape analyses, we made several predictions about which mutations had been selected when during the evolution experiment. Deep sequencing of population samples from different time points generally confirmed these predictions, demonstrating the power of landscape reconstruction analyses for understanding and ultimately predicting evolutionary dynamics, even under complex scenarios of environmental change.
Laboratory Screening for Children Entering Foster Care
Authors: Greiner Mary V. , Beal Sarah J. , Nause Katie , Staat Mary Allen , Dexheimer Judith W. , Scribano Philip V. 
Published: November 2017

OBJECTIVES:To determine the prevalence of medical illness detected by laboratory screening in children entering foster care in a single, urban county.METHODS:All children entering foster care in a single county in Ohio were seen at a consultation foster care clinic and had laboratory screening, including testing for infectious diseases such as HIV, hepatitis B, hepatitis C, syphilis, and tuberculosis as well as for hemoglobin and lead levels.RESULTS:Over a 3-year period (2012–2015), laboratory screening was performed on 1977 subjects entering foster care in a consultative foster care clinic. The prevalence of hepatitis B, hepatitis C, syphilis, and tuberculosis were all found to be &lt;1%. There were no cases of HIV. Seven percent of teenagers entering foster care tested positive for Chlamydia. A secondary finding was that 54% of subjects were hepatitis B surface antibody–negative, indicating an absence of detected immunity to the hepatitis B virus.CONCLUSIONS:Routine laboratory screening for children entering foster care resulted in a low yield. Targeted, rather than routine, laboratory screening may be a more clinically meaningful approach for children entering foster care.
Tolerance in Internet gaming disorder: A need for increasing gaming time or something else?
Authors: King Daniel L. , Herd Madeleine C. E. , Delfabbro Paul H. 
Published: November 2017

Background and aims
The criterion of tolerance in DSM-5 Internet gaming disorder (IGD) refers to a need for increasing time spent gaming. However, this focus on “need for gaming time” may overlook some of the broader motivations, outcomes, or effects of gaming that underlie excessive play. This study aimed to explore regular and problematic gamers’ experiences and perceptions of tolerance in IGD.

Methods
An online survey of 630 adult gamers yielded 1,417 text responses to open-ended questions. A thematic analysis of 23,373 words was conducted to extract dominant themes.

Results
Participants reported that they increasingly desired game items, status, or story progress as they became more involved or invested in games. As players develop higher standards of play in games, an increasing number of potential reward outcomes may have diminishing mood-modifying effects. None of the participants, including those with self-reported IGD, explicitly referred to a need for increasing time spent gaming.

Discussion and conclusions
These results suggest that players may be motivated by preferences for specific goals or reinforcers in games rather than wanting an amount of time spent gaming. Thus, problematic gaming may involve a need for completion of increasingly intricate, time-consuming, or difficult goals to achieve satisfaction and/or reduce fears of missing out. Further research is needed to determine whether these cognitive and motivational factors related to gaming stimuli should extend or replace the concept of tolerance in IGD or be considered as separate but related processes in disordered gaming.
The concept of the foveola anatomical reconstruction in the surgical treatment of full-thickness macular tears using intraoperative OCT control
Authors: Bayborodov Jaroslav V. 
Published: November 2017

Background. The concept of foveola anatomical reconstruction in surgical treatment of macular holes is a minimally invasive approach based on sparing principles of visualization and removal of transparent structures.
Purpose. To estimate the practical value of high-resolution intraoperative OCT control (IOСT) at surgical treatment of macular holes.
Materials and methods. The study included 95 patients (95 eyes) with macular holes from 400 to 900 microns in diameter, being during the period from September 2015 to October 2016.
Results. IOСT control increases the anatomical and functional success of macular hole surgery, allowing determining more accurately the vitreomacular interface anatomical structures during the procedure and making more precise choice of tamponade agent to the end of it.
Conclusion. The proposed foveola anatomical reconstruction in surgical treatment of full-thickness macular holes enhanced by intraoperative OCT control provides high functional and anatomic postoperative retinal indices.
The graft survival evaluation after subtotal penetrating keratoplasty in the long-term postoperative period
Authors: Berdieva Nigina N. , Shapovalova Eleonora V. , Riks Inna A. 
Published: November 2017

Introduction. Until the 2000s, in diseases leading to corneal blindness, it was expediently to perform subtotal keratoplasty in order to provide an organ-sparing effect and restore visual functions. Such procedures were not widely spread due to a great number of problems; they were performed with extended depressurization of the eye, and had a high risk of intraoperative complications. Nowadays, many ophthalmologists face the remote consequences of subtotal keratoplasty.
Aim. The purpose is to evaluate the transplant after subtotal penetrating keratoplasty (SPK) and visual functions in the remote postoperative period.
Materials and methods. We have examined 14 patients (14 eyes), aged from 28 to 81 years, at 6-10 years after SPK. Visual acuity (VA) testing, autorefractometry and confocal microscopy (Confoscan 4) were performed.
Results. According to visual acuity testing results, patients were divided into 3 groups: 1st group with high VA (more than 0.2 in 7.2% of patients), 2nd group with medium VA (from 0.2 to 0.005 in 21.4% of patients), and 3rd low VA (less than 0.005 in 71.4% of patients). Before the SKP, VA was 0.004-0.7. After the SKP, the indices varied from light sensation with correct light projection to 1.0. High rate was in 21.5%, medium in 35.7%, low in 42.8% of cases. According to autorefractometry data, the cylindrical component was in average 6.5 3.0. Most often, astigmatism was revealed in the low (up to 3) and high degree (more than 6). According to confocal microscopy data, the average density of endothelial cells was 1700 50 cells/mm2.
Conclusion. More than a half of patients has preserved good visual functions and a transparent transplant at 6-10 years after the SKP, and this significantly improves the quality of patients life.
A new method for treatment severe forms of dry keratoconjunctivitis (preliminary results)
Authors: Safonova Tatyana N. , Gladkova Olga V. , Novikov Ivan A. , Boev Vasil I. 
Published: November 2017

The aim is to improve the treatment method of severe keratoconjunctivitis sicca (KCS) forms using designed soft contact lenses (SCL).
Material and methods. An original SCL of silicone hydrogel material with individual optical power, consisting of a non-through depot filled with 0.05% Cyclosporin A (CyA) was designed. The therapeutic CyA saturated SCL was used in 5 patients (1 male and 4 females; 7 eyes) aged from 34 to 66 years, with severe KCS, who were constantly wearing them for 7-14 days. Patients additionally instilled hyaluronic acid containing non-preserved artificial tears up to 6 times a day. Standard ophthalmic examination, Schirmer test, tear break-up-time test, tests using vital dyes (assessed using the Oxford scale), tear osmolarity measurements (TearLab System, USA), tear pH measurement by a highly sensitive litmus test, conjunctival culture, measurement of the interpalpebral fissure width were carried out, the ocular surface disease index (OSDI) was determined. Treatment results were assessed in 1 week, 1 month, and 3 months since the SCL wear start.
Results. The use of therapeutic CyA saturated SCL allows to achieve complete corneal epithelization, and helps to reduce inflammation within the time from 1 week up to 1 month, significantly reducing the treatment timeframe of severe forms of KSC in comparison to standard therapy.
Conclusion.The developed treatment method for severe forms of the KCS consists in using specifically designed therapeutic SCL which provides an even CyA 0.05% release on the ocular surface, while instilling non-preserved artificial tears. Preliminary results show a high efficacy of this method in terms of reducing corneal epithelization time up to 1 week-1 month and resolving inflammation on the ocular surface.
Reverse Shoulder Arthroplasty for the Treatment of Rotator Cuff Deficiency
Authors: Cuff Derek J. , Pupello Derek R. , Santoni Brandon G. , Clark Rachel E. , Frankle Mark A. 
Published: November 2017

Abstract:
We previously evaluated 94 patients (96 shoulders) who underwent reverse shoulder arthroplasty using a central compressive screw with 5.0-mm peripheral locking screws for baseplate fixation and a center of rotation lateral to the glenoid as treatment for end-stage rotator cuff deficiency. The purpose of this study was to report updated results at a minimum follow-up of 10 years. Forty patients (42 shoulders) were available for clinical follow-up. In the patients available for study, implant survivorship, with the end point being revision for any reason, was 90.7%. Since our 5-year report, 2 patients underwent revision surgery; 1 patient sustained a periprosthetic fracture 7 years postoperatively and 1 patient had a dislocation because of chronic shoulder instability at 8 years postoperatively. At a minimum follow-up of 10 years, the patients continued to maintain their improved outcome scores and range of motion, which were comparable with earlier follow-up evaluations.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.