bluuebunny/crossref_metadata_2025_split huggingface dataset:
X—Synthetic Philosophy: A Restatement
Authors: Schliesser Eric 
Published: October 2024

Abstract
The guiding thread of the paper is the diagnosis that the advanced division of cognitive labour (that is, intellectual specialization) engenders a set of perennial, political and epistemic challenges (Millgram 2015) that, simultaneously, also generate opportunities for philosophy. In this paper, I re-characterize the nature of synthetic philosophy as a means to advance and institutionalize philosophy. In §i, I treat Plato’s Republic as offering two models to represent philosophy’s relationship to the other sciences within the advanced division of labour. I highlight that for Plato intellectual specialization is central not just to economic but also to political life; and yet, that the very dispersion of scientific expertise, and its esoteric nature, also generates non-trivial challenges to the recognition and political utilization of knowledge. From Plato we can infer that in imperfect circumstances, philosophy’s self-constitution is, in part, a response to these challenges in political epistemology. However, how philosophy is institutionalized differs through time. In §ii, I re-introduce my conceptualization of synthetic philosophy and restate it. I use recent work by Dorst (2023) to illustrate synthetic philosophy and to identify some of the processes that give rise to the need for it. In §§ii–iii, I contrast my account with the evolving ways that Philip Kitcher has conceptualized synthetic philosophy, in order to make more precise the version promoted here. I do so not just because Kitcher and I use the same term, ‘synthetic philosophy’, but because the temptations inherent in Kitcher’s approach should be resisted.
Modified creatinine index as a marker of skeletal muscle mass in peritoneal dialysis patients
Authors: Ng Jack Kit-Chung , Fung Winston Wing-Shing , Chan Gordon Chun-Kau , Cheng Phyllis Mei-Shan , Pang Wing-Fai , Chow Kai-Ming , Szeto Cheuk-Chun 
Published: October 2024

ABSTRACT

Background
Sarcopenia is common in peritoneal dialysis (PD) patients. Modified creatinine index (MCrI) by the Canaud's formula and single-pool Kt/V value is an accurate surrogate marker for muscle mass in hemodialysis patients. However, the method of calculation and validity of MCrI has not been tested in PD.

Methods
In the exploratory cohort, we studied 138 consecutive patients converted from PD to hemodialysis. Their MCrI during PD, calculated by the Canaud's formula with total weekly Kt/V, and the conventional MCrI after conversion to HD, were compared by the Bland–Altman method. Their correlation with muscle mass as determined by bioimpedance spectroscopy and creatinine kinetic methods was explored. The result was then validated in a second cohort of 605 incident PD patients.

Results
In the exploratory cohort, the average bias of computing MCrI during PD and hemodialysis was 0.758 mg/kg/day (95%CI −4.356 to 5.873 mg/kg/day). The MCrI during PD significantly correlated with the muscle mass by creatinine kinetics (r = .684, P &lt; .0001) and by bioimpedance spectroscopy (r = .641, P &lt; .0001), but not with protein nitrogen appearance, overhydration, or adipose tissue mass, and the result was similar in the validation cohort. For incident PD patients, MCrI quartile was significantly associated with the risk of death from all cause in 12 months (Gray's test, P = .013) but not conversion to chronic hemodialysis (P = .14).

Conclusion
In PD patients, MCrI computed by the Canaud's formula and total weekly Kt/V is a simple and reliable marker of skeletal muscle mass and may serve as a short-term prognostic indicator.
Bilateral lung volume reduction surgery outperforms the unilateral approach in functional improvement
Authors: Okumus Özlem , Seebacher Gernot , Valdivia Daniel , Slama Alexis , Darwiche Kaid , Karpf-Wissel Rüdiger , Wienker Johannes , Collaud Stephane , Kampe Sandra , Hegedüs Balazs , Aigner Clemens 
Published: October 2024

Abstract

OBJECTIVES
Lung volume reduction surgery (LVRS) is an established treatment approach for patients with severe pulmonary emphysema, enhancing lung function and quality of life in selected patients. Functional benefits and outcomes after uni- versus bilateral lung volume reduction remain a topic of debate.

METHODS
A retrospective analysis of patients undergoing LVRS from January 2018 to October 2022 was conducted. After encouraging initial results, the standard unilateral LVRS approach was switched to bilateral. The goal of this study was to assess the impact on functional outcomes at 3 and 6 months post-surgery compared to preoperative levels for the uni- versus the bilateral approach.

RESULTS
A total of 83 patients were included (43 bilateral, 40 unilateral). Baseline demographic and functional parameters were comparable between groups. The most common complication was prolonged air leak in 19 patients (11 in the unilateral group, 8 in the bilateral group). Two patients died perioperatively (2.4%). Overall, LVRS improved forced expiratory volume in 1 s by 8.3% after 3 and 12.5% after 6 months postoperatively compared to baseline. Bilateral surgery presented significantly superior forced expiratory volume in 1 s improvement than unilateral approach at both 3 (29.2% versus 2.9%; P = 0.0010) and 6 months (21.5% versus 3%; P = 0.0310) postoperatively. Additionally, it reduced hyperinflation (residual volume) by 23.1% after 3 months and by 17.5% after 6 months, compared to reductions of 16% and 9.1% in the unilateral group.

CONCLUSIONS
Bilateral approach resulted in better functional outcomes 3 and 6 months postoperatively compared to unilateral surgery.
Delayed jamming-induced oscillatory migration patterns of epithelial collectives under long-range confinement
Authors: Lohmann S , Pramotton F M , Taloni A , Ferrari A , Poulikakos D , Giampietro C 
Published: October 2024

Abstract
Collective dynamics of cells in confined geometry regulate several biological processes including cell migration, proliferation, differentiation, and communication. In this work, combining simulation with experimental data, we studied the oscillatory motion of epithelial sheets in smaller areas of confinement, and we linked the monolayer maturation induced-jamming with the wave formation. We showed that epithelial cell populations with delayed jamming properties use the additional time available from this delay to coordinate their movement, generating wave motion in larger areas of confinement compared to control populations. Furthermore, the effects of combining geometric confinement with contact guiding micro-gratings on this wave formation were investigated. We demonstrated that collective migratory oscillations under large geometrical confinement depend on the jamming state of the cell monolayers. The early dynamical state of the experimental results obtained was simulated by self-propelled Voronoi computations, comparing cells with solid-like and fluid-like behavior. Together our model describes the wave formation under confinement and the nodal oscillatory dynamics of the early dynamic stage of the system.
Insight Box: Collective behavior of cells in confined spaces impacts biological processes. Through experimental data combined with simulations, the oscillatory motion of epithelial sheets in small areas of confinement was described. A correlation between the level of cell jamming and the formation of waves was detected. Cell populations with delayed jamming presented wave motion in larger confinement areas. The effects of combining geometric confinement with substrate micro-gratings demonstrated that the collective migratory oscillations in large confinement areas rely on the jamming state of cells. The early dynamical state was simulated using self-propelled Voronoi computations that help to understand wave formation under confinement and the nodal oscillatory dynamics of early-stage systems.
Sputum culture conversion and its predictors among drug-resistant pulmonary tuberculosis patients in eastern Ethiopia
Authors: Gamachu Mulugeta , Deressa Alemayehu , Regassa Lemma Demissei , Bayu Miesso , Mussa Ibsa , Kumsa Fekede Asefa , Dingeta Tariku 
Published: October 2024

Abstract

Background
Evidence of time to culture conversion is used to predict the time of cure from the disease and the overall drug-resistant tuberculosis (TB) treatment duration. Even though evidence about sputum culture conversion is enormous in TB treatment, no study has yet been done in our areas, where cases are common. The study aimed to assess the time to sputum conversion and its predictors among drug-resistant TB patients from October 2013 to September 2021 in eastern Ethiopia.

Methodology
A retrospective cohort study was conducted in eastern Ethiopia among 273 drug-resistant TB patients who were treated from October 2013 to September 2021 at Dire Dawa City and Harari regional treatment centres. The Kaplan–Meier method was used to estimate the median time of sputum culture conversion. Cox proportional hazards regression was employed to detect the predictors of sputum culture conversion. An adjusted hazard ratio (aHR) with 95% confidence interval (CI) was used to determine the strength and significance of the association.

Results
Of the 273 drug-resistant TB patients, the sputum culture of 216 (79.12%) patients became negative in a median time of 3 months (interquartile range 2–7). The time to sputum culture conversion was negatively associated with underweight (aHR 0.65 [95% CI 0.49 to 0.90]) and poor adherence (aHR 0.41 [95% CI 0.24 to 0.69]). The time to sputum culture conversion was also positively associated with patients resistant to two or more drugs (aHR 1.58 [95% CI 1.07 to 2.32]) and patients receiving a short treatment regimen (aHR 2.24 [95% CI 1.10 to 2.55]).

Conclusions
A shorter culture conversion rate was observed compared with the median time recommended by the World Health Organization. Being underweight, poor adherence to treatment, resistance to two or more drugs and receiving a short treatment regimen were found to be predictors of time to sputum culture conversion. Implementing nutrition assessment, counselling and support of drug adherence may improve sputum culture conversion.
Nontechnical Factors and Postprocedural Considerations for Image-guided Breast Biopsy
Authors: Dodelzon Katerina , Bhole Sonya , Coffey Kristen , Dashevsky Brittany Z , Mullen Lisa , Parikh Jay , Reig Beatriu , Grimm Lars 
Published: October 2024

Abstract
Beyond the technical aspects, success and long-term patient outcomes of image-guided breast biopsies depend on the overall patient experience. Patient experience in turn is influenced by intangible factors, such as environmental features during the procedure; patient-centered communication prior to, during, and subsequent to the procedure; and management of expectations and biopsy complications. Here, we review evidence-based literature and results of a national Society of Breast Imaging survey on approaches to both mitigate and manage common image-guided core biopsy complications as well as nontechnical strategies to improve the patient biopsy experience.
Vocal functional flexibility in a nonprimate vocal learning species
Authors: Magdaleno Francisco R , Quintanilla Salinas Isaac , Rothstein Stephen I 
Published: October 2024

Abstract
Can nonhuman animals use the same acoustic signal to transmit different illocutions on different occasions? This communicative capacity is known as vocal functional flexibility and occurs, for example, in speech, when a sentence serves different illocutionary forces or functions on different occasions based on changes to visual and intonational cues. Although common in human speech, there is a lack of clear evidence for this ability in other species. Here, we examined a likely candidate, the Brown-headed Cowbird (Molothrus ater), which is a vocal-learning songbird species that develops a repertoire of structurally distinct song types. Most of this species’ songs are directed towards conspecific males and females less than a meter away, making it unusually easy to determine the apparent target of songs, unlike the broadcast songs done by most songbirds. Songs directed to other males have clear aggressive/threatening intent, while those to females involve courtship/sexual intent. Extensive prior work shows that male cowbirds perform the visual display that accompanies singing differently in these two social settings and also modulate the intonation of song types differently. Because of these display and tonal modulations, constancy of song type usage across male- vs female-directed singing would provide evidence of vocal functional flexibility. Herein, we examined 4,828 songs in three captive flocks containing twenty-four males and thirty females during the breeding season. Males did not use their song types randomly and had strongly favored songs and less commonly used ones. Importantly, favored song types and less commonly used ones were the same whether directing courtship song to a female, aggressive song to another male or singing nonsocially with no receiver nearby. Results were consistent within and across the three flocks, providing strong evidence of vocal functional flexibility. These findings indicate that some species may evolve the ability to modulate and exaggerate visual display components and prosody more than vocal presentation per se because a learned phonological system in this and possibly other species is constrained by its vital role as an indicator trait.
DMRdb: a disease-centric Mendelian randomization database for systematically assessing causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases
Authors: Zheng Xiao , Tian Zhihao , Che Xiaohui , Zhang Xu , Xiang Yu , Ge Zhijian , Zhai Zhaoyu , Ma Qinfeng , Pan Jianbo 
Published: October 2024

Abstract
Exploring the causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases is fundamental to the life sciences. However, large-scale research using Mendelian randomization (MR) analysis is currently lacking. To address this, we introduce DMRdb (http://www.inbirg.com/DMRdb/), a disease-centric Mendelian randomization database, designed to systematically assess causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases. The database consists of three main components: (i) 6640 high-quality disease genome-wide association studies (GWASs) from public sources that were subjected to rigorous quality filtering and standardization; (ii) over 497 billion results from MR analyses involving 6640 disease GWAS datasets, 16 238 expression quantitative trait loci (eQTLs) data, 2564 protein quantitative trait loci (pQTLs) data, 12 000 methylation quantitative trait locus (meQTLs) data and 825 metabolites data and (iii) over 380 000 causal relationship pairs from 1223 literature sources relevant to MR analyses. A user-friendly online database was developed to allow users to query, search, and download all the results. In summary, we anticipate that DMRdb will be a valuable resource for advancing our understanding of disease mechanisms and identifying new biomarkers and therapeutic targets.
Subclinical Myocardial Fibrosis in South African Youth With HIV: Results From the CTAAC-Heart Study
Authors: Jao Jennifer , Zar Heather J , Kahts Morné , Jermy Stephen , Egan Daniel , Nyathi Mothabisi N , Asafu-Agyei Nana Akua , Legbedze Justine , Carkeek Emma , Jele Nomawethu , Mautsa Tafadzwa , Bonner Lauren Balmert , McComsey Grace A , Feinstein Matthew , Kurland Irwin J , Myer Landon , Ntusi Ntobeko A B 
Published: October 2024

Abstract

Background
Few data exist on myocardial fibrosis and inflammation in youth with HIV.

Methods
We performed cardiovascular magnetic resonance (CMR) on a cross section of South African youth: youth with perinatally acquired HIV (YPHIV) undergoing antiretroviral therapy (ART), youth with nonperinatally acquired HIV (YNPHIV) receiving ART, and youth without HIV. Quantile regression models were fit to assess the association between HIV status and CMR outcomes: subclinical fibrosis (late gadolinium enhancement [LGE] mass and fraction, native T1, extracellular volume) and inflammation (native T1, T2 mapping).

Results
Of 464 youth, 287 were YPHIV, 87 were YNPHIV, and 90 were HIV seronegative. The median age was 16 years (range, 11–24). LGE mass was higher in YPHIV and YNPHIV than in youth who were HIV seronegative (1.85 vs 2.00 vs 1.41 g, respectively), as was fraction (5.8% vs 6.4% vs 4.5%); native T1 was highest in YNPHIV. In adjusted analyses, when compared with youth with HIV seronegativity, YPHIV and YNPHIV exhibited higher LGE mass (β = 0.468, P = .001; β = 0.544, P = .002) and LGE fraction (β = 1.587, P &lt; .001; β = 1.781, P &lt; .001). CMR outcomes were similar between YPHIV and YNPHIV.

Conclusions
Despite ART use, YPHIV and YNPHIV appear to have higher subclinical myocardial fibrosis than youth who are HIV seronegative and healthy adults in South Africa and may benefit from early screening/monitoring for cardiovascular disease.
Epidemiology and Outcomes of Recurrent C Difficile Infection Among Hematopoietic Cell Transplant Recipients: A Single-center, Retrospective 10-year Study
Authors: Sanchez Eduardo , Krantz Elizabeth M , Escobar Zahra Kassamali , Tverdek Frank , Rosen Emily A , Oshima Masumi Ueda , Carpenter Paul A , Pergam Steven A , Liu Catherine 
Published: October 2024

Abstract

Background
There are limited data on the contemporary epidemiology of recurrent Clostridioides difficile infection (CDI) among hematopoietic cell transplant (HCT) recipients. We aimed to determine the incidence, risk factors, and outcomes for recurrent CDI among HCT recipients.

Methods
We conducted a retrospective study of adult HCT recipients between 2012 and 2021 diagnosed with index CDI between HCT day −7 and +100. Recurrent CDI was defined as new symptoms and a positive test within 12 weeks after treatment for index CDI. Cox proportional hazards models were used to investigate associations between prespecified variables (age, neutropenia, exposure to antibiotics with antianaerobic coverage, cytomegalovirus viremia/disease, and metronidazole monotherapy) and recurrent infection, presented as hazard ratios with 95% confidence intervals (CI).

Results
Of 3479 HCT recipients, 416 (12%) had index CDI and were treated with oral vancomycin (31%), metronidazole (41%), oral vancomycin and metronidazole (29%). Of 381 patients eligible for recurrent CDI analysis, 35 had recurrent infection; cumulative incidence was 10% (95% CI, 7–13) at 12 weeks. In the 14 days after recurrence, 2/25 (8%) patients required hospital admission; none died within 30 days. Metronidazole monotherapy for treatment of index CDI was associated with an increased rate of recurrence (adjusted hazard ratio, 2.0; 95% CI, 1.0–4.0; P = .048).

Conclusions
Recurrent CDI occurred in 10% of HCT recipients in the early posttransplant period and was associated with use of metronidazole. Further study is needed to characterize risk factors for recurrent CDI among HCT recipients to guide use of agents aimed at preventing recurrence.
Promoting civil discourse on social media using nudges: A tournament of seven interventions
Authors: Celadin Tatiana , Panizza Folco , Capraro Valerio 
Published: October 2024

Abstract
In this article, we test and compare several message-based nudges designed to promote civil discourse and reduce the circulation of harmful content such as hate speech. We conducted a large pre-registered experiment (N = 4,081) to measure the effectiveness of seven nudges: making descriptive norms, injunctive norms, or personal norms salient, cooling down negative emotions, stimulating deliberation or empathy, and highlighting reputation. We used an online platform that reproduces a social media newsfeed and presented the nudge as a message when entering the platform. Our findings indicate that none of the nudges significantly impacts participants’ engagement with harmful content. At the same time, nudges making descriptive norms salient selectively increase participants’ overall engagement with relatively harmless content. Additionally, making injunctive norms salient increased the likelihood of liking harmless posts. Exploratory text analysis also reveals that highlighting reputation leads to more substantial and coherent comments on harmful posts. These results suggest that nudges that activate norm considerations represent a promising approach to promoting civil discourse and making social media a safer and more inclusive space for all.
Links between climatic histories and the rise and fall of a Pacific chiefdom
Authors: Shen Chuan-Chou , Beardsley Felicia , Gong Shou-Yeh , Kataoka Osamu , Yoneda Minoru , Yokoyama Yusuke , Hu Hsun-Ming , Huang Chun-Yuan , Liu Sze-Chieh , Chiang Hong-Wei , Wei Hsin-Lin , Chung Yun-Chuan , Jiang Leilei , Lin Albert Yu-Min , Fox James , David Mordain , Lebehn Jason , Barnabas Jason , Kohler Gus , Richards Zoe T , Hobbs Jean-Paul A , McCoy Mark D 
Published: October 2024

AbstractSea level rise and climate change are shaping present societies, particularly those on oceanic islands. Few historical examples could serve as references for these changes. One such potential model is the Saudeleur Dynasty with its capital Nan Madol on the Pacific Island of Pohnpei. However, the timing of its construction, as well as the dynasty's fluctuations and potential environmental influences, has remained unresolved. Through the analyses of 230Th ages on 171 dates on corals fragments used as building materials and charcoal 14C ages from excavations, 2 major construction phases spanning from the 10th to the 15th century CE can be discerned. The results show that the first phase of the site's construction, spanning the 10th–12th century, marked the dynasty's rise. The second period, spanning from the late 12th to the early 15th century, provides the most substantial evidence for the demise of the island-scale chiefdom and a significant societal reorganization. The phases are centuries earlier than previously believed. With this new evidence, we propose the hypothesis that variations in the El Niño-Southern Oscillation and subsidence-related sea level rise presented major challenges for building and maintaining Nan Madol, and thus, influenced the course of the island's history. This case serves as a compelling example of how adverse climatic conditions can spur investments—in this case, in seawater defense under high sea levels—yet ultimately may contribute to abandonment. It offers lessons for island nations, showcasing coastal resilience in the face of worsening catastrophic events that unfolded over generations.
People are skeptical of headlines labeled as AI-generated, even if true or human-made, because they assume full AI automation
Authors: Altay Sacha , Gilardi Fabrizio 
Published: October 2024

Abstract
The rise of generative AI tools has sparked debates about the labeling of AI-generated content. Yet, the impact of such labels remains uncertain. In two preregistered online experiments among US and UK participants (N = 4,976), we show that while participants did not equate “AI-generated” with “False,” labeling headlines as AI-generated lowered their perceived accuracy and participants’ willingness to share them, regardless of whether the headlines were true or false, and created by humans or AI. The impact of labeling headlines as AI-generated was three times smaller than labeling them as false. This AI aversion is due to expectations that headlines labeled as AI-generated have been entirely written by AI with no human supervision. These findings suggest that the labeling of AI-generated content should be approached cautiously to avoid unintended negative effects on harmless or even beneficial AI-generated content and that effective deployment of labels requires transparency regarding their meaning.