bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxygen Delivery as a Limiting Factor in Modelling Dicopper(II) Oxidase Reactivity
Authors: Gülzow Jana , Hörner Gerald , Strauch Peter , Stritt Anika , Irran Elisabeth , Grohmann Andreas 
Published: March 2017

AbstractInvited for the cover of this issue is the group of Gerald Hörner and Andreas Grohmann at the Technical University of Berlin. The image depicts that the browning of cut fruit is effected by copper‐ and oxygen‐dependent oxygenases, leading to melanine pigments, which are polymeric ortho‐quinone derivatives. Read the full text of the article at 10.1002/chem.201605868.
Synthesis of 4,4‐Disubstituted 3‐Methylidenechroman‐2‐ones as Potent Anticancer Agents
Authors: Jakubowski Rafał , Pomorska Dorota K. , Długosz Angelika , Janecka Anna , Krajewska Urszula , Różalski Marek , Mirowski Marek , Bartosik Tomasz , Janecki Tomasz 
Published: March 2017

AbstractThe synthesis of a new library of 4,4‐disubstituted 3‐methylidene‐3,4‐dihydro‐2H‐chroman‐2‐ones applying Horner–Wadsworth–Emmons methodology for the construction of an exo‐methylidene moiety is reported. Corresponding 3‐diethoxyphosphorylchroman‐2‐ones were synthesized in a three‐step reaction sequence consisting of O‐methylation of ethyl 2‐diethoxyphosphoryl‐3‐oxoalkanoates, followed by reaction of the obtained 2‐diethoxyphosphoryl‐3‐methoxy‐2‐alkenoates with phenols or 1‐naphthol. The resulting 3‐diethoxyphosphorylochromen‐2‐ones proved to be effective Michael acceptors in reactions with various Grignard reagents. Preliminary biological evaluations showed that many of the synthesized 3‐methylidenechroman‐2‐ones possess very high cytotoxic activity against NALM‐6 and HL‐60 cancer cell lines (IC50<1.0 μm) as well as high activity against the MCF‐7 cancer cell line (IC50<10 μm). Furthermore, two of the highly active 3‐methylidenechroman‐2‐ones with geminal methyl and ethyl substituents at position 4 showed promising therapeutic indexes of 10 and 13 in tests against human umbilical vein endothelial cells (HUVECs).
Color specification of two new resin composites and influence of stratification on their chromatic perception
Authors: Gueli Anna M. , Pedullà Eugenio , Pasquale Stefania , La Rosa Giusy R. , Rapisarda Ernesto 
Published: March 2017

AbstractAccurate color reproduction in conservative dentistry is fundamental to the aesthetic success of the restorations. The need to specify the color objectively has been known for some years, and this article aims to make a contribution to this field. This work is part of a multidisciplinary research project, and it has a double aim. The first purpose was to measure the color differences between the two new composite resin restorative materials and the most used dental color scale. Measurements show some differences from color shades indicated by the manufacturers and those obtained from experimental data. The influence of different order of enamel and dentin layers on color perception was also investigated to evaluate clinical strategies useful to obtain desired result. Relevant differences are observed in the stratification of dentin and enamel discs especially for one of the two studied composites.
Preventing intimate partner violence via the Internet: A randomized controlled trial of emotion‐regulation and conflict‐management training for individuals with aggression problems
Authors: Hesser Hugo , Axelsson Sandra , Bäcke Victoria , Engstrand Jonna , Gustafsson Tina , Holmgren Elin , Jeppsson Ulrika , Pollack Maria , Nordén Kjell , Rosenqvist Dan , Andersson Gerhard 
Published: March 2017

ObjectiveThe aim of this randomized controlled trial was to investigate the effect of an Internet‐delivered cognitive behaviour therapy (iCBT), which incorporated emotion‐regulation and conflict‐resolution techniques, on intimate partner violence (IPV). Another aim was to test the theoretical underpinnings of the treatment model using mediation analysis.MethodSixty‐five participants with aggression problems in intimate adult relationships were recruited from the community and were randomly assigned to iCBT or to a monitored waitlist control. Participants were assessed with standardized self‐report measures of IPV or aggression (Multidimensional Measure of Emotional Abuse, Revised Conflict Tactics Scale, and Aggression Questionnaire), relationship quality (Dyadic Adjustment Scale), anxiety or depression symptomatology (Patient Health Questionnaire; Generalized Anxiety Disorder Screener), at pretreatment, posttreatment (8 weeks), and 1‐year follow‐up. Process variables (subscales of Dysfunctional and Emotional Regulation Scale and Anger Rumination Scale) were assessed weekly over the active treatment phase.ResultsRobust linear regression analysis of all randomized participants showed significant treatment effects on emotional abuse relative to control at postassessment. Mediation analysis using growth curve modeling revealed that the treatment effect was partially mediated by changes in emotion‐regulation ability. Controlled effects on secondary outcomes were also observed. Analyses of uncontrolled effects indicted that gains on IPV were maintained at 1‐year follow‐up.ConclusionsiCBT focusing on enhancing conflict‐resolution skills and emotion‐regulation ability has the potential to reduce IPV among self‐recruited individuals with mild forms of abusive behaviour in intimate relationships. Emotion‐regulation ability is potentially a key therapeutic process of change.Key Practitioner Message

Internet‐delivered clinician‐guided cognitive behaviour therapy is a viable treatment option for reducing intimate partner violence among self‐recruited individuals with mild forms of abusive behaviour.
For persons who display patterns of frequent and severe violence, other treatments are most likely needed.
Emotion‐regulation training is potentially a key therapeutic component that ought to be incorporated in interventions targeting IPV.
A flowcytometric analysis to efficiently quantify multiple innate immune cells and T Cell subsets in human blood
Authors: Draxler D.F. , Madondo M.T. , Hanafi G. , Plebanski M. , Medcalf R.L. 
Published: March 2017

AbstractThe balance of inflammation and immunosuppression driven by changed ratios in diverse myeloid and T cell subsets, as well as their state of activation and ability to migrate to lymphoid compartments or inflammatory sites, has emerged as a highly active area of study across clinical trials of vaccines and therapies against cancer, trauma, as well as autoimmune and infectious diseases. There is a need for effective protocols which maximally use the possibilities offered by modern flow cytometers to characterize such immune cell changes in peripheral blood using small volumes of human blood. Additionally, longitudinal clinical studies often use cryopreserved samples, which can impact flow cytometric results. To efficiently gauge both the innate and the adaptive immune response, two novel 15‐color antibody panels to identify key myeloid and T cell subsets and their functional potential were established. This approach was used to compare cellular immune profiles in fresh whole blood and in matched cryopreserved peripheral blood mononuclear cells (PBMCs). Cocktail I was designed to identify and characterize myeloid cell populations including dendritic cells (DCs), monocytic monocyte‐derived suppressor cells (MO‐MDSC), and monocytes, determining further core aspects of their state of maturity, T cell stimulatory (or inhibitory) potential, and migration capability. Cocktail II was used for phenotyping diverse T cells subsets, and their key migration and functional regulatory capabilities. The two 15‐color antibody panels for the evaluation of both immune‐stimulating and immunosuppressive processes presented herein allowed for efficient evaluation of the balance of immune activation versus immunosuppression across key blood cells, with good resolution for all 15 markers stained for in each panel. Gating strategies for the myeloid and T cells are presented to further support specific subset identification. This protocol was shown to be reproducible across donors and useful to study both RBC‐lysed whole blood and cryopreserved PBMCs. © 2017 International Society for Advancement of Cytometry
Menstrual cycle loss and resumption among patients with anorexia nervosa spectrum eating disorders: Is relative or absolute weight more influential?
Authors: Berner Laura A. , Feig Emily H. , Witt Ashley A. , Lowe Michael R. 
Published: March 2017

AbstractObjectivePrior research suggests that both body mass index (BMI) and weight suppression (highest past weight minus current weight; WS) are important in determining adult anorexia nervosa (AN) severity. We examined associations between amenorrhea and WS, DSM‐5 BMI severity category, and highest premorbid BMI among patients with AN.MethodParticipants (N = 69) were adult female AN‐spectrum patients at two residential treatment facilities. At admission, height, and weight were measured, and participants completed questionnaires assessing menstrual status and weight history.ResultsGreater WS, adjusted for BMI, was associated with menstrual function at admission. First amenorrhea onset occurred at a normal BMI for 38.5% of participants. Premorbid highest BMI positively correlated with BMI at amenorrhea onset, and higher BMI at amenorrhea onset was associated with higher BMI at menses resumption.DiscussionThese findings add to the literature indicating that relative and absolute weight status are dual indicators of illness severity in AN, and preliminarily suggest that a large proportion of adults who present for treatment initially may have shown symptoms of starvation at a normal BMI. Results underscore the need to focus on weight loss in early detection efforts and may inform target weight setting in the treatment of AN.
Transoral ultrasonic surgery of pharyngolaryngeal giant hemangioma after ethylene‐vinyl alcohol copolymer (Onyx) embolization
Authors: Valls–Mateus Meritxell , Román Luis San , Macho Juan , Nadal Alfons , Bernal–Sprekelsen Manuel , Vilaseca Isabel 
Published: March 2017

ABSTRACTBackgroundCervico‐mediastinal hemangiomas in adulthood are rare and slow‐growing vascular tumors. The optimal treatment for giant hemangiomas is controversial. In asymptomatic cases, clinical observation is generally recommended.MethodsWe report the transoral resection of a pharyngolaryngeal hemangioma (diameters of 44 × 56 × 39 mm) with tracheal involvement and mediastinal extension. Clinically, the patient had throat foreign body sensation, severe dyspnea and stridor. The hemangioma was first embolized by injecting ethylene‐vinyl alcohol copolymer (Onyx) transorally, and then the obstructive aspect of the tumor was resected with a bipolar and ultrasonic clamp (ThunderBeat®, Olympus).ResultsTwo months after surgery, nasal fiberendoscopy showed complete disappearance of the vascular mass at the larynx and hypopharynx, with a normal mobility of the larynx.ConclusionIn symptomatic patients, surgical reduction of large pharyngolaryngeal hemangiomas may be feasible by direct embolization and transoral ultrasonic resection. Both may provide an almost bloodless surgical field. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1239–1242, 2017
Differences in seasonality and temperature dependency of stand transpiration and canopy conductance between Japanese cypress (Hinoki) and Japanese cedar (Sugi) in a plantation
Authors: Saito Takami , Kumagai Tomo'omi , Tateishi Makiko , Kobayashi Nakako , Otsuki Kyoichi , Giambelluca Thomas W. 
Published: March 2017

AbstractIn this paper, we present an investigation of interspecies differences in transpiration of the 2 most common plantation forest tree species in Japan, both in the family Cupressaceae with different northern limits of native distribution, Japanese cypress (Hinoki; Chamaecyparis obtusa Sieb. et Zucc.) and Japanese cedar (Sugi; Cryptomeria japonica D. Don). The stem sap flow rate was measured in 2 nearby stands of similar leaf area index in a 42‐year‐old plantation. Single‐tree and stand‐scale transpiration rates (Etre and Esta, respectively) were observed during an ideal autumn environment. At the stand scale, mean sap flux density of Hinoki was greater than that of Sugi, whereas total sapwood area per ground area was smaller in Hinoki than Sugi. Because the 2 variables had counterbalancing effects on transpiration, Esta of Hinoki was similar to (94% of) that of Sugi. This offset was also found between the mean Etre of the 2 species. Esta was similar between the stands from May to October, whereas Esta of Sugi was notably greater than that of Hinoki from February to April. During these 3 months, the difference in cumulative Esta was 21.7 mm, which accounted for 79% of the difference in annual Esta between Hinoki and Sugi (192 and 219 mm/year, respectively). We found that canopy conductance (Gc) and its sensitivity to the mean vapour pressure deficit during daylight hours in Sugi were particularly high in early spring, whereas those in Hinoki shifted gradually throughout the growing season. This difference was related to the optimal temperature of Gc in Sugi, which was approximately 10 °C lower than that in Hinoki. Our results suggest that plantations of water‐conserving species such as Hinoki produce timber slowly but yield water resources generously. Moreover, for plantations of trees sensitive to high temperature, such as Sugi, managers should be concerned about possible future decline caused by anticipated global warming.
Feeling Thanks and Saying Thanks: A Randomized Controlled Trial Examining If and How Socially Oriented Gratitude Journals Work
Authors: O'Connell Brenda H. , O'Shea Deirdre , Gallagher Stephen 
Published: March 2017

ObjectiveThis study examined the effect of a reflective interpersonal gratitude journal, a reflective‐behavioral interpersonal gratitude journal and an active control journal, on primary qualities of well‐being and depression.MethodParticipants (n = 192; 67.2% female) completed this 3‐month longitudinal randomized controlled design.ResultsParticipants in the reflective‐behavioral condition experienced the greatest improvements in affect balance and reductions in depression at immediate posttest. Both gratitude interventions improved affect balance at 1 month, compared to the control. Changes in affect balance for those in the reflective‐behavioral condition were mediated by the rate at which people expressed gratitude in their existing relationships. This effect was moderated by participant's baseline depressive status.ConclusionExpressing felt gratitude to others appears to be a crucial step in deriving benefits, and these benefits may not be limited to the emotionally healthy. Given the applied popularity of gratitude interventions, understanding not only if but also how they work is essential.
Feasibility of gadoteric acid for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) at the wrist and knee and comparison with Gd‐DTPA
Authors: Rehnitz Christoph , Klaan Bastian , Do Thuy , Barié Alexander , Kauczor Hans‐Ulrich , Weber Marc‐André 
Published: March 2017

PurposeTo assess the feasibility of gadoteric acid for delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (dGEMRIC) and to compare the dGEMRIC values obtained using gadoteric acid with those obtained by an equimolar dose of Gd‐DTPA.Materials and MethodsAt 3T, dGEMRIC of the wrist was performed twice using a T1‐weighted 3D‐volumetric interpolated breath‐hold examination sequence in 16 healthy volunteers (10 women; mean age 26.0 years) using gadoteric acid first and Gd‐DTPA 3 weeks later. In addition, 24 patients with knee pain were examined using gadoteric acid (n = 12; seven women; mean age 45.8 years) or Gd‐DTPA (n = 12; four women; mean age 47.1 years). T1 values, the relative decrease in T1, and the delta R1 were compared using t‐tests. Interobserver agreement was assessed using the intraclass correlation (ICC) between two independent readers.ResultsAt the wrist, there was no significant difference in delta R1 values (0.34 ± 0.10/s, 95% confidence interval [0.30;0.38]/s for gadoteric acid and 0.32 ± 0.09 [0.29;0.35]/s for Gd‐DTPA, P = 0.24) or the relative decrease in T1 (0.25 ± 0.06 [0.29;0.35] msec for gadoteric acid and 0.24 ± 0.05 [0.22;0.27] msec for Gd‐DTPA, P = 0.35). High observer agreement was found at precontrast (ICC = 0.87, P < 0.001) and postcontrast (ICC = 0.89, P < 0.001). Similarly, at the knee, there was no significant difference in delta R1 (0.39 ± 0.18 [0.32;0.47]/s for gadoteric acid and 0.41 ± 0.09 [0.38;0.45]/s for Gd‐DTPA, P = 0.59) or the relative decrease in T1 (0.30 ± 0.10 [0.26;0.34] msec for gadoteric acid and 0.33 ± 0.05 [0.30;0.35] msec for Gd‐DTPA, P = 0.28). High ICCs of 0.96 (P < 0.01) were noted both at precontrast and postcontrast.ConclusiondGEMRIC using gadoteric acid is feasible and yields comparable values when compared with Gd‐DTPA.Level of Evidence: 2Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2017;46:1433–1440.
The Association of Diabetes and Obesity With Prostate Cancer Progression: HCaP‐NC
Authors: Khan Saira , Cai Jianwen , Nielsen Matthew E. , Troester Melissa A. , Mohler James L. , Fontham Elizabeth T. H. , Hendrix Laura H. , Farnan Laura , Olshan Andrew F. , Bensen Jeannette T. 
Published: March 2017

BACKGROUNDThe role of race in modifying the association among diabetes, obesity, and prostate cancer (CaP) progression is not well studied. We evaluated diabetes and obesity in association with time to CaP progression in White Americans (Whites) and Black Americans (Blacks).METHODSOur study sample consisted of 363 White and 284 Black research participants from the Health Care Access and CaP Treatment in North Carolina (HCaP‐NC) cohort. The association between self‐reported diabetes or obesity and CaP progression (mean follow‐up time approximately 5 years) was assessed using Cox proportional hazards modeling, with adjustment for potential confounders. Stratum‐specific hazard ratio (HR) estimates for Whites and Blacks were evaluated.RESULTSSelf‐reported diabetes was not associated with CaP progression in the cohort as a whole (HR: 0.86, 95%CI: 0.54, 1.35), or among racially defined groups (Whites, HR: 1.03, 95%CI: 0.50, 2.13 or Blacks, HR: 0.77, 95%CI: 0.43, 1.39). Obesity was positively associated with CaP progression among Whites, in models including (HR: 1.79, 95%CI: 1.08, 2.97), and excluding (HR: 1.80, 95%CI: 1.09, 2.96) diabetes as a covariate. No association was observed between obesity and CaP progression in Blacks or the cohort as whole.CONCLUSIONSSelf‐reported diabetes was not associated with CaP progression In HCaP‐NC. Obesity was associated with CaP progression only among White research participants. Prostate 77:878–887, 2017. © 2017 Wiley Periodicals, Inc.
Impact of Comorbidity and Prescription Drugs on Haemorrhage in Cholecystectomy
Authors: Strömberg J. , Sandblom G. 
Published: March 2017

AbstractBackgroundThe purpose of the present study was to analyse the impact of patient‐related risk factors and medication drugs on haemorrhagic complications following cholecystectomy.MethodsAll cholecystectomies registered in the Swedish population‐based Register for Gallstone Surgery and ERCP (GallRiks) were identified. Risk factors for bleeding were assessed by linking data in the GallRiks to the National Patient Register and the Prescribed Drug Register, respectively. The risk of haemorrhage leading to intervention was determined by variable regression, and Kaplan–Meier analysis assessed survival rate following perioperative haemorrhage.ResultsA total of 94,557 patients were included between 2005 and 2015, of which 799 (0.8%) and 1192 (1.3%) patients were registered as having perioperative and post‐operative haemorrhage, respectively. In multivariable analysis, an increased risk of haemorrhagic complications was seen in patients with cerebrovascular disease (p = 0.001), previous myocardial infarction (p = 0.001), kidney disease (p = 0.001), heart failure (p = 0.001), diabetes (p = 0.001), peripheral vascular disease (p = 0.004), and obesity (p = 0.005). Prescription of tricyclic antidepressant (p = 0.018) or dipyridamole (p = 0.047) was associated with a significantly increased risk of perioperative haemorrhage. However, this increase in risk did not remain significant following Bonferroni correction for mass significance. Perioperative haemorrhage increased the risk of death occurring within the first post‐operative year [Hazard Ratio, (HR) 4.9, CI 3.52–6.93] as well as bile duct injury (OR 2.45, CI 1.79–3.37).ConclusionThe increased risk of haemorrhage associated with comorbidity must be taken into account when assessing patients prior to cholecystectomy. Perioperative bleeding increases post‐operative mortality and is associated with an increased risk of bile duct injury.
The Wiener criterion and quasilinear uniformly elliptic equations
Authors: Michael J.H. , Ziemer William P. 
Published: March 2017

In this paper the Dirichlet problem is considered for a wide class of quasilinear elliptic equations with

C^1

coefficients in divergence form. The main result is that if

Ω

is an arbitrary bounded open subset of

R^n

and

ψ

is a continuous function defined on the boundary of

Ω

, then there is a solution to the equation in

Ω

which assumes the boundary data continuously at all points at which a Wiener condition is satisfied. This condition is satisfied at all points of the boundary except for a set of capacity zero.

Résumé

Dans ce travail nous considérons le problème de Dirichlet pour une large classe d’équations elliptiques avec des coefficients de classe

C^1

. Le résultat principal est le suivant. Soit

Ω

un ensemble ouvert borné arbitraire dans

R^n

, et soit

ψ

une fonction continue sur la frontière de

Ω

. Alors il y a une solution de l’équation dans

Ω

qui est continue et égale à

ψ

dans tous les points où la condition de Wiener est satisfaite. Cette condition est satisfaite dans tous les points de la frontière, à l’exception d’un ensemble de capacité nulle.
An isoperimetric inequality in ℝ3
Authors: Esteban Maria J. 
Published: March 2017

In this paper we give an inequality of isoperimetric type in

ℝ^3

, which is a natural extension of the better known isoperimetric inequalities in

ℝ^2

. It shows the relationship between the “degree” of a function from

ℝ^3

to

S^3

and a certain functional which is relevant in the study of mesons in Nuclear Physics.

Résumé

Dans cet article on démontre une inégalité isopérimétrique dans

ℝ^3

, qui généralise de façon naturelle une inégalité isopérimétrique classique dans

ℝ^2

. Cette inégalité met en évidence la relation existant entre le « degré » des fonctions définies dans

ℝ^3

et à valeurs dans

S^3

et une certaine fonctionnelle liée à l’étude des mésons en Physique Nucléaire.
A proof of Weinstein’s conjecture in ℝ2n
Authors: Viterbo Claude 
Published: March 2017

We prove that a hypersurface of contact type in

(ℝ^{2n},\:\sum dx_{i} \wedge dy^{i})

has a closed characteristic. A geometric trick is used to reduce this problem to finding T-periodic solutions of a Hamiltonian system. This system is studied using the Clarke–Ekeland–Lasry dual action functional.

Résumé

On démontre que toute hypersurface de genre contact de

(ℝ^{2n},\:\sum dx_{i} \wedge dy^{i})

admet au moins une caractéristique fermée. Une astuce géométrique ramène notre problème à la recherche d’orbites T périodiques d’un système hamiltonien. Ce système est analysé en utilisant la fonctionnelle d’action duale de Clarke–Ekeland–Lasry.