bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Iodine‐Catalyzed Oxidation of N‐Substituted Indoles by Using Chloramine‐B: A Facile and Practical Approach to Isatins.
Authors: Liu Peijun , Guo Jiajing , Wei Wentao , Liu Xiaozu , Sun Pinghua 
Published: August 2016

AbstractA variety of the pharmaceutically interesting title compounds bearing different functionalities at the arene ring is readily prepared under mild conditions.
ChemInform Abstract: Synthesis of N,N‐Disubstituted 1‐Aryl‐1,3‐dihydro‐2H‐isoindole‐2‐carbothioamides.
Authors: Kobayashi Kazuhiro , Shigemura Yuuho , Tanmatsu Miyuki 
Published: August 2016

AbstractThe isothiocyanatomethyl derivatives cyclize on treatment with methanesulfonic acid.
ChemInform Abstract: Bifunctional Thiourea Catalyzed Asymmetric Michael Addition of Anthrone to Methyleneindolinones.
Authors: Zhao Huaili , Xiao Mingyan , Xu Lubin , Wang Liang , Xiao Jian 
Published: August 2016

AbstractThe regioselectivity and stereoselectivity of the synthesized hybrid derivatives of oxindoles and anthrone can be finely tuned by change of substituents in the starting methyleneindolinones.
ChemInform Abstract: Asymmetric Fluorination of 4‐Substituted Pyrazolones Catalyzed by Quinine.
Authors: Bao Xiaoze , Wei Shiqiang , Zou Liwei , Song Yuming , Qu Jingping , Wang Baomin 
Published: August 2016

Abstractleading to 4‐fluorinated pyrazolones (II) and (IV) with moderate to good enantioselectivities
ChemInform Abstract: Copper(II)‐Catalyzed Oxidative Cross‐Coupling of Anilines, Primary Alkyl Amines, and Sodium Azide Using TBHP: A Route to 2‐Substituted Benzimidazoles.
Authors: Mahesh Devulapally , Sadhu Pradeep , Punniyamurthy Tharmalingam 
Published: August 2016

AbstractThe reaction has a broad substrate scope and succeeds using aliphatic as well as benzylic amines as the alkyl amine component, but fails using heterocyclic amines as the aniline component.
ChemInform Abstract: Reactivity of 2,1‐Benzisoxazole in Palladium‐Catalyzed Direct Arylation with Aryl Bromides.
Authors: Aidene Mohand , Belkessam Fatma , Soule Jean‐Francois , Doucet Henri 
Published: August 2016

AbstractArylations of benzisoxazole with a variety of (hetero)aryl bromides afford 3‐arylbenzoisoxazoles in moderate to high yields.
ChemInform Abstract: Synthesis of 5‐Fluoro‐ and 5‐Bromoalkylisoxazoles via Nitrosation of 1,1‐Dihalocyclopropanes with Sulfur Trioxide Activated Nitrosyl Chloride.
Authors: Bondarenko Oksana B. , Vinogradov Aleksandr A. , Komarov Arseniy I. , Smirnov Andrei S. , Zyk Nikolai V. 
Published: August 2016

AbstractIn the case of bromofluorocyclopropane the reaction proceeds with excellent chemoselectivity exclusively leading to 5‐fluoroisoxazoles.
ChemInform Abstract: A Practical Green Chemistry Approach to Synthesize Fused Bicyclic 4H‐Pyranes via an Amine Catalyzed 1,4‐Addition and Cyclization Cascade.
Authors: Li Jun‐Long , Li Qiang , Yang Kai‐Chuan , Li Yi , Zhou Liang , Han Bo , Peng Cheng , Gou Xiao‐Jun 
Published: August 2016

AbstractSome compounds exhibit promising antibacterial activity.
ChemInform Abstract: A New and Efficient Synthesis of Pyrazole‐Fused Isocoumarins on the Solid Surface of Magnetically Separable Fe3O4@SiO2‐SO3H Nanoparticles.
Authors: Mukherjee Sayan , Kundu Ashis , Pramanik Animesh 
Published: August 2016

AbstractA new procedure enables the synthesis of the title species through condensation of arylhydrazones and ninhydrin under solvent‐free conditions applying sulfonic acid functionalized silica‐coated magnetic nanoparticles.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of Novel O‐Heterocycles by Domino Suzuki Coupling‐Michael Addition Reaction
Authors: Zhu Qihua , Nie Feng , Feng Jingjie , Li Yuyan , Wang Xuyan , Xu Yungen 
Published: August 2016

Abstractof vinyl/aryl bromides with hydroxyphenylboronic acids
ChemInform Abstract: Regioselective Suzuki—Miyaura Reactions of the Bis(triflate) of 6,7‐Dihydroxy‐2,2‐dimethylchroman‐4‐one.
Authors: Pajtas David , Dihen Karoly , Konya Krisztina , Langer Peter 
Published: August 2016

AbstractDepending on the stoichiometry, regioselective 6,7‐bisarylation or 7‐monoarylation is achieved.
ChemInform Abstract: Calix[n]arenes: Active Organocatalysts for the Synthesis of Densely Functionalized Piperidines by One‐Pot Multicomponent Procedure.
Authors: Palermo V. , Sathicq A. , Liberto N. , Fernandes S. , Langer P. , Jios J. , Romanelli G. 
Published: August 2016

AbstractThe reaction provides functionalized piperidines with high anti‐selectivity.
ChemInform Abstract: Straightforward Hantzsch Four‐ and Three‐Component Condensation in the Presence of Triphenyl(propyl‐3‐sulfonyl)phosphoniumtrifluoromethanesulfonate {[TPPSP]OTf} as a Reusable and Green Mild Ionic Liquid Catalyst.
Authors: Vahdat Seyed Mohammad , Zolfigol Mohammad Ali , Baghery Saeed 
Published: August 2016

AbstractThe title reactions provide quinoline and acridine derivatives, resp., in excellent yields and are advantageous with regards to mild conditions, operational simplicity, and short reaction times.
ChemInform Abstract: Carbon Nanotube—Ruthenium Hybrids for the Partial Reduction of 2‐Nitrochalcones: Easy Access to Quinoline N‐Oxides.
Authors: Basu Pallabita , Prakash Praveen , Gravel Edmond , Shah Nimesh , Bera Kalisankar , Doris Eric , Namboothiri Irishi N. N. 
Published: August 2016

AbstractThe nanotube hybrids promote the reduction of the nitro group and the following intramolecular condensation of the ‐NH2 to the carbonyl function.
ChemInform Abstract: An Alkyne Diboration/6π‐Electrocyclization Strategy for the Synthesis of Pyridine Boronic Acid Derivatives.
Authors: Mora‐Rado Helena , Bialy Laurent , Czechtizky Werngard , Mendez Maria , Harrity Joseph P. A. 
Published: August 2016

AbstractThe novel diboration/6π‐electrocyclization strategy enables rapid access to bicyclic pyridines, although the suitability of this method to access monocyclic heterocycles will likely require further method development.
ChemInform Abstract: Asymmetric Formal Aza‐Diels—Alder Reaction of Trifluoromethyl Hemiaminals with Enones Catalyzed by Primary Amines.
Authors: Zhang Sheng , Cha Lide , Li Lijun , Hu Yanbin , Li Yanan , Zha Zhenggen , Wang Zhiyong 
Published: August 2016

AbstractThe scalable highly efficient method offers a diastereo‐ and enantioselective access to various pharmaceutically active perfluoroalkylpiperidine scaffolds.
ChemInform Abstract: A High Performance Route for the Synthesis of Dihydropyrrolo[1,2‐f]phenanthridine Scaffolds by Using a One‐Pot Four‐Component Reaction.
Authors: Marandi Ghasem , Saghatforoush Lotfali , Kabiri Roya 
Published: August 2016

AbstractPyridine‐containing pyrrolophenanthridines are efficiently prepared by multicomponent condensation of pyridinecarbaldehydes, malononitrile, phenanthridine, and isocyanides.
ChemInform Abstract: Indium Trichloride (InCl3) Catalyzed Synthesis of Fused 7‐Azaindole Derivatives Using Domino Knoevenagel—Michael Reaction.
Authors: Dongare Sakharam B. , Chavan Hemant V. , Surwase Datta N. , Bhale Pravin S. , Mule Yoginath B. , Bandgar Babasaheb P. 
Published: August 2016

Abstractfollowed by intramolecular cyclization starting from cyclic 1,3‐dicarbonyls, substituted aldehydes, and pyrrolecarbonitrile (II)
ChemInform Abstract: Stereoselective Solvent‐Free Synthesis of 4‐Hydroxy‐1,3‐thiazinane‐2‐thiones.
Authors: Nasiri Farough , Zolali Amin , Kadkhoda Jamileh 
Published: August 2016

AbstractThe title compounds are prepared by one‐pot three‐component reaction of primary amines, CS2, and α,β‐unsaturated aldehydes.
ChemInform Abstract: Studies on the Aza‐Claisen Rearrangement of 7‐ to 9‐Membered Vinylazacycles.
Authors: Jung Jong‐Wha , Suh Young‐Ger , Kim Seok‐Ho , Lee Won‐Il , Kim Seon‐Mi , Jung Jae‐Kyung , Jang Jaebong , Sim Jaehoon 
Published: August 2016

AbstractThe amide enolate‐induced aza‐Claisen rearrangement of the vinylazacycles furnishes 11‐ to 13‐membered macrolactams with an internal (E)‐olefinic bond, not accessible by conventional methods.
ChemInform Abstract: Astellifadiene: Structure Determination by NMR Spectroscopy and Crystalline Sponge Method, and Elucidation of Its Biosynthesis.
Authors: Matsuda Yudai , Mitsuhashi Takaaki , Lee Shoukou , Hoshino Manabu , Mori Takahiro , Okada Masahiro , Zhang Huiping , Hayashi Fumiaki , Fujita Makoto , Abe Ikuro 
Published: August 2016

AbstractThis rapid, nondestructive, and complete structure analysis of a minute quantity of oily title compound (I), the structure of which belongs to one of the most difficult classes of compounds for absolute structure determination, provides a particularly important example in natural product structure determination.
ChemInform Abstract: Reassignment of the Absolute Configuration of Plakinidone from the Sponge Consortium Plakortis halichondrioides—Xestospongia deweerdtae Using a Combination of Synthesis and a Chiroptical Approach.
Authors: Jimenez‐Romero Carlos , Rode Joanna E. , Rodriguez Abimael D. 
Published: August 2016

AbstractThe absolute configuration of plakinidone (I) is re‐assigned as (11S,17R) from the formerly reported (11S,17S) diastereomer.
ChemInform Abstract: Hydrothermally Synthesized CeO2 Nanowires for H2S Sensing at Room Temperature.
Authors: Li Zhijie , Niu Xinyue , Lin Zhijie , Wang Ningning , Shen Huahai , Liu Wei , Sun Kai , Fu Yong Qing , Wang Zhiguo 
Published: August 2016

AbstractThe title nanowires are hydrothermally synthesized from aqueous mixtures of Ce(NO3)3, urea, and NaOH (autoclave, 100 °C, 24 h).
ChemInform Abstract: N‐Allenyl Amides and O‐Allenyl Ethers in Enantioselective Catalysis
Authors: Manoni Elisabetta , Bandini Marco 
Published: August 2016

AbstractReview: [recent advances in the use of such activated π‐systems in metal‐mediated and metal‐free enantioselective transformations; 32 refs.
ChemInform Abstract: Octa‐1,7‐diene‐4,5‐diamine Derivatives: Useful Intermediates for the Stereoselective Synthesis of Nitrogen Heterocycles and Ligands for Asymmetric Catalysis
Authors: Gualandi Andrea , Grilli Stefano , Savoia Diego 
Published: August 2016

AbstractReview: [65 refs.
ChemInform Abstract: Solar Disinfection and Lime Stabilization Processes for Reduction of Pathogenic Bacteria in Sewage Effluents and Biosolids for Agricultural Purposes in Yemen
Authors: Al‐Gheethi Adel A. S. , Ismail Norli , Efaq A. N. , Bala D. , Al‐Amery Ramzy M. A. 
Published: August 2016

AbstractReview: 95 refs.
ChemInform Abstract: Research Progress in Electroanalytical Techniques for Determination of Antimalarial Drugs in Pharmaceutical and Biological Samples
Authors: Thapliyal Neeta , Chiwunze Tirivashe E. , Karpoormath Rajshekhar , Goyal Rajendra N. , Patel Harun , Cherukupalli Srinivasulu 
Published: August 2016

AbstractReview: 145 refs.
Comprehensive CFD simulation of the optimizations of geometric structures and operating parameters for industrial acetylene hydrogenation reactors
Authors: Tian Liang , Hu Guihua , Du Wenli , Qian Feng 
Published: August 2016

AbstractIn this study, for the first time, comprehensive simulations of the industrial adiabatic and isothermal reactors utilized for the hydrogenation of acetylene were performed by computational fluid dynamics (CFD). The standard k–ϵ and Spalart‐Allmaras models were employed for describing the turbulence characteristics of the adiabatic and isothermal reactors, respectively. The porous medium model was applied to the flow of catalyst particles. The laminar finite‐rate model was employed for simulating the reaction in the reactor. The results obtained from simulations were in close agreement with those obtained from the industrial adiabatic reactor. Based on the validated CFD models, three operating conditions of the adiabatic reactor are simulated for comparing the selectivity of acetylene; as a result, H and T segmentation is utilized as an optimum process parameter. The different geometric structures of the adiabatic and isothermal reactors are simulated for obtaining the best diameter to length (D/L) ratio. The simulation results indicated an optimal D/L of 0.3852 for the adiabatic reactor, and the diameter‐to‐length ratio exerts a marginal effect on the reaction selectivity of isothermal reactors.
Random network modelling approach to investigate the single‐phase and quasi‐static immiscible two‐phase flow properties in the Mesaverde formation
Authors: Bashtani Farzad , Kryuchkov Sergey , Bryan Jonathan , Maini Brij , Kantzas Apostolos 
Published: August 2016

AbstractUnderstanding the microscopic flow behaviour of hydrocarbons and water in porous media gains importance as more and more reservoirs are being exploited. Network modelling techniques could be extended to tighter media as long as Darcy's law is applicable. 3D random networks are constructed in order to represent the Mesaverde formation which is located in north Wyoming, USA. The network modelling software solves the fundamental equations of single‐phase and two‐phase immiscible flow incorporating wettability and contact angle assuming a quasi‐static displacement mechanism. Macroscopic properties of the porous media network representation such as porosity, absolute permeability, and formation factor are calculated and whenever possible compared to experimental data. Subsequently, immiscible two‐phase flow properties such as capillary pressure, relative permeability, and resistivity curves are predicted and compared to available experimental data. The effect of interfacial tension alteration is also investigated as an attempt to demonstrate the capability of the network modelling technique to show physical fluid behaviour. It is observed that the capillary pressure curve obtained using MICP data can be used to calibrate and validate the network model generated to represent the sample. The study shows that the modified random network modelling technique is capable of modelling low permeable porous medium and predicting single‐phase and immiscible two‐phase flow properties assuming quasi‐static displacement mechanism.
Kinetic modelling of cell growth, substrate utilization, and biosurfactant production from solid agrowaste (Beta vulgaris) by Bacillus licheniformis STK 01
Authors: Amodu Olusola S. , Ojumu Tunde V. , Ntwampe Seteno K. O. 
Published: August 2016

AbstractThe kinetics of cell growth, substrate utilization, and biosurfactant production by Bacillus licheniformis STK 01 from a solid agrowaste substrate (Beta vulgaris) and a refined substrate (mineral salts, MS) was investigated. Data obtained were fitted to the integrated Monod equation, logistic models, and Leudeking–Piret model using nonlinear regression analyses. The maximum cell growth was observed after 72 h of fermentation for both substrates. The highest biosurfactant production was 5.8 ± 0.5 g/L when the B. vulgaris waste substrate was used, while the production increased up to 9.78 ± 1.02 g/L when MS was used. The biosurfactant produced from B. vulgaris and MS lowered the surface tension of the broth to 30 and 23.5 mN/m respectively. Furthermore, from the kinetic data analyses, cell growth and B. vulgaris utilization were described by the logistic model and modified Monod equation, respectively, with the maximum cell growth rate of 0.026 h−1, cell yield of 0.617, and the Monod saturation constant being 0.418 g/L. Similarly, biosurfactant production was best described by the logistic model while the production rate constant was 0.140 h−1. This study is applicable, among other areas, in the design of biological systems augmented with B. vulgaris waste.
Multiplex real‐time PCR detection and relative quantification of periodontal pathogens
Authors: Coffey Joshua , Choudhry Mydah , Shlossman Marc , Makin Inder Raj S. , Singh Vineet K. 
Published: August 2016

AbstractPeriodontitis is a chronic inflammatory disease, which is strongly associated with certain pathogenic bacteria. The aim of this study was to develop a real‐time multiplex polymerase chain reaction (PCR) assay to detect and quantify bacterial species associated with periodontitis. We targeted detection and relative quantification of the following five bacterial species relevant to periodontal diseases: Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. The conserved regions of the genome of these species were targeted with oligos and TaqMan probes in real‐time PCR assays. The species‐specific TaqMan oligos and TaqMan probes showed no cross‐amplification, and there was no loss of amplification yield in multiplex real‐time PCR assays. All five bacterial targets were amplified analogous to the template concentrations used in these assays. This multiplex real‐time PCR strategy could potentially be used to detect the bacterial species in periodontal pockets of patients with periodontal diseases. This assay may also serve as a quick tool for profiling and quantifying bacteria relevant to periodontal diseases and likely be a valuable tool for clinical translational research.
Unprecedented Catalytic Wet Oxidation of Glucose to Succinic Acid Induced by the Addition of n‐Butylamine to a RuIII Catalyst
Authors: Podolean Iunia , Rizescu Cristina , Bala Camelia , Rotariu Lucian , Parvulescu Vasile I. , Coman Simona M. , Garcia Hermenegildo 
Published: August 2016

AbstractA new pathway for the catalytic wet oxidation (CWO) of glucose is described. Employing a cationic Ru@MNP catalyst, succinic acid is obtained in unprecedently high yield (87.5 %) for a >99.9 % conversion of glucose, most probably through a free radical mechanism combined with catalytic didehydroxylation of vicinal diols and hydrogenation of the resulted unsaturated intermediate.
Ionic Liquid Induced Band Shift of Titanium Dioxide
Authors: Weber Henry , Kirchner Barbara 
Published: August 2016

AbstractIonic liquids (ILs) have become an established option for the use as electrolytes in dye‐sensitized solar cells. In the present study, the adsorption of a multitude of different ILs on a TiO2 surface is studied systematically, focusing on the energetic modifications of the semiconductor. The cation was found to generally cause an energetic downward shift of the TiO2 band levels by accepting electron density from the surface, and the anions were observed to function in the opposite direction, raising the energy levels by donating electron density. Both effects counterbalance each other, leaving the desired outcome dependent on the choice of the specific IL, i.e., the choice of the cation/anion combination. The correlation of the band levels with the properties of the IL was successfully achieved. The dipole moment of the adsorbed ionic liquid species showed little to no correlation with the semiconductor energetics, but the charge transfer calculated by radical Voronoi tessellation revealed a high correlation. The current findings contribute to a deeper understanding of the role of the electrolyte in dye‐sensitized solar cells, and ILs in general, and help with choosing and tuning of the electrolyte solutions in existing applications.
Oxytocin and behavior: Lessons from knockout mice
Authors: Caldwell Heather K. , Aulino Elizabeth A. , Freeman Angela R. , Miller Travis V. , Witchey Shannah K. 
Published: August 2016

ABSTRACTIt is well established that the nonapeptide oxytocin (Oxt) is important for the neural modulation of behaviors in many mammalian species. Since its discovery in 1906 and synthesis in the early 1950s, elegant pharmacological work has helped identify specific neural substrates on which Oxt exerts its effects. More recently, mice with targeted genetic disruptions of the Oxt system—i.e., both the peptide and its receptor (the Oxtr)—have further defined Oxt's actions and laid some important scientific groundwork for studies in other species. In this article, we highlight the scientific contributions that various mouse knockouts of the Oxt system have made to our understanding of Oxt's modulation of behavior. We specifically focus on how the use of these mice has shed light on our understanding of social recognition memory, maternal behavior, aggression, and several nonsocial behaviors. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 190–201, 2017
State dependence, personality, and plants: light‐foraging decisions in Mimosa pudica (L.)
Authors: Simon Franz W. , Hodson Christina N. , Roitberg Bernard D. 
Published: August 2016

AbstractPlants make foraging decisions that are dependent on ecological conditions, such as resource availability and distribution. Despite the field of plant behavioral ecology gaining momentum, ecologists still know little about what factors impact plant behavior, especially light‐foraging behavior. We made use of the behavioral reaction norm approach to investigate light foraging in a plant species that exhibits rapid movement: Mimosa pudica. We explored how herbivore avoidance behavior in M. pudica (which closes its leaflets temporarily when disturbed) is affected by an individual's energy state and the quality of the current environment and also repeatedly tested the behavior of individuals from two seed sources to determine whether individuals exhibit a “personality” (i.e., behavioral syndrome). We found that when individuals are in a low‐energy state, they adopt a riskier light‐foraging strategy, opening leaflets faster, and not closing leaflets as often in response to a disturbance. However, when plants are in a high‐energy state, they exhibit a plastic light‐foraging strategy dependent on environment quality. Although we found no evidence that individuals exhibit behavioral syndromes, we found that individuals from different seed sources consistently behave differently from each other. Our results suggest that plants are capable of making state‐dependent decisions and that plant decision making is complex, depending on the interplay between internal and external factors.
Kicking the tyres of a heart failure trial: physician response to the approval of sacubitril/valsartan in the USA
Authors: Packer Milton 
Published: August 2016

AbstractAngiotensin receptor–neprilysin inhibition has been shown to be superior to target doses of an ACE inhibitor in reducing the risk of cardiovascular death and clinical disease progression in patients with chronic heart failure and a reduced EF. Nevertheless, although sacubitril/valsartan has been available in the USA for a year, uptake of the drug by practitioners has been slow, in part because of misconceptions about the pivotal trial that demonstrated its efficacy in heart failure (PARADIGM‐HF). This review addresses questions that have been raised in the USA about the design of the trial as well as the patients who were studied, the replicability and applicability of the results, and the safety of neprilysin inhibition. The totality of evidence indicates that the PARADIGM‐HF trial used an appropriate comparator; enrolled patients typical of those seen in the community with mild to moderate symptoms; yielded highly persuasive and replicable results; and demonstrated benefits that are applicable to patients taking subtarget doses of ACE inhibitors and ARBs. Regulatory review in the USA concluded that the established advantages of sacubitril/valsartan on cardiovascular death and disease progression outweighed hypothetical uncertainties about the long‐term effects of neprilysin inhibition in patients who might not have survived without the drug. Accordingly, both the new US and European Society of Cardiology heart failure guidelines recommend sacubitril/valsartan as the preferred approach to inhibiting the renin–angiotensin system in patients with chronic heart failure who are currently receiving an ACE inhibitor or ARB.