bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial Disparities in Outpatient Mental Health Service Use Among Children Hospitalized for Traumatic Brain Injury
Authors: Moore Megan , Jimenez Nathalia , Graves Janessa M. , Rue Tessa , Fann Jesse R. , Rivara Frederick P. , Vavilala Monica S. 
Published: November 2017

Objective:
To examine racial differences in mental health service utilization after hospitalization for traumatic brain injury (TBI) among children with Medicaid insurance.

Design and Main Measures:
Retrospective analysis of the MarketScan Multi-State Medicaid database from 2007 to 2012 was performed. Outpatient mental health service utilization (psychiatric and psychological individual and group services) was compared at TBI hospitalization, from discharge to 3 months and from 4 to 12 months after discharge, between children of non-Hispanic white (NHW), non-Hispanic black (NHB), Hispanic, and “Other” racial groups. Multivariable mixed-effects Poisson regression models with robust standard errors were utilized.

Results:
A total of 5674 children (aged <21 years) were included in the study. There were no differences by race/ethnicity in mental health service utilization during hospitalization. At 3 months postdischarge, NHB children and children in the “Other” racial category were significantly less likely to receive outpatient mental health services than NHW children (NHB relative risk [RR] = 0.84; 95% confidence interval [CI], 0.72-0.98; Other RR = 0.72; 95% CI, 0.57-0.90). At 12 months, all racial minority children were significantly less likely to receive outpatient mental health services than NHW children (NHB RR = 0.84; 95% CI, 0.75-0.94; Hispanic RR = 0.72; 95% CI, 0.55-0.94; Other RR = 0.71; 95% CI, 0.60-0.84).

Conclusions:
Racial disparities in utilization of outpatient mental health services exist for minority children hospitalized for TBI and insured by Medicaid. Future research should focus on improving transitions of care from inpatient to outpatient services for these children.
Efficacy of a Micro-Prompting Technology in Reducing Support Needed by People With Severe Acquired Brain Injury in Activities of Daily Living: A Randomized Control Trial
Authors: O'Neill Brian , Best Catherine , O'Neill Lauren , Ramos Sara D. S. , Gillespie Alex 
Published: November 2017

Objective:
To evaluate the effectiveness of an automated interactive prompting technology in supporting the morning routine of persons with acquired brain injury. The morning routine included maintaining personal hygiene and dressing.

Setting:
An inpatient neurorehabilitation hospital.

Participants:
Persons with acquired brain injury who required prompting when following their morning routine (n = 24), but were not limited by physical disability or dysphasia, took part in the study. Participants (67% with traumatic brain injury) had impairment on indices of memory and executive function.

Design:
A randomized control trial evaluated the effect of an automated interactive micro-prompting device on the number of prompts by trained staff required for successful completion of the morning routine.

Main Measures:
Study-specific checklists assessed sequence performance, errors, and verbal prompts required over baseline, rehabilitation as usual, intervention, and return to baseline conditions.

Results:
The intervention significantly reduced the support required to complete the task compared with usual rehabilitation.

Conclusions:
Micro-prompting technology is an effective assistive technology for cognition, which reduces support needs in people with significant cognitive impairments.
Correspondence of the Boston Assessment of Traumatic Brain Injury-Lifetime and the VA Comprehensive TBI Evaluation
Authors: Radigan Lauren J. , McGlinchey Regina E. , Milberg William P. , Fortier Catherine Brawn 
Published: November 2017

Objective:
To compare the diagnosis of positive versus negative for mild traumatic brain injury (mTBI) using the Boston Assessment of TBI-Lifetime (BAT-L), a validated forensic clinical interview used to identify TBI in research, to the diagnosis of mTBI in the clinical polytrauma service using the Comprehensive TBI Evaluation (CTBIE).

Participants:
Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn Veterans who were enrolled in the Translational Research Center for TBI and Stress Disorders longitudinal cohort study and received a CTBIE at a Veterans Health Administration healthcare facility (n = 104).

Main Measures:
The BAT-L, CTBIE, and Neurobehavioral Symptom Inventory.

Results:
There was poor correspondence between the BAT-L and CTBIE mTBI diagnoses (κ = 0.283). The CTBIE showed moderate sensitivity but poor specificity relative to the BAT-L. The agreement did not improve after removing individuals who had failed symptom validity measures, as assessed by the Validity-10 scale of the Neurobehavioral Symptom Inventory.

Conclusions:
This lack of correspondence highlights the difficulties in diagnosing mTBI in Veterans using retrospective self-report. Future work is needed to establish a reliable and valid method for identifying military mTBI both for the care of our Veterans and for appropriate distribution of benefits.
Agitated Behavior and Activities of Daily Living Retraining During Posttraumatic Amnesia
Authors: Trevena-Peters Jessica , Ponsford Jennie , McKay Adam 
Published: November 2017

Background:
Patients in posttraumatic amnesia (PTA) may receive limited rehabilitation due to the risk of overstimulation and agitation. This assumption has not been tested.

Objective:
To examine the relationship between agitated behavior and participation in therapy for retraining of activities of daily living (ADL) while in PTA.

Setting:
Inpatient rehabilitation center.

Participants:
A total of 104 participants with severe traumatic brain injury, admitted to rehabilitation, in PTA of more than 7 days.

Intervention:
ADL retraining during PTA followed errorless and procedural learning principles.

Design:
Group comparison and regression modeling of patient agitation data from a randomized controlled trial comparing ADL retraining in PTA (treatment) versus no ADL retraining in PTA (treatment as usual, TAU).

Outcome Measures:
Agitation using the Agitated Behavior Scale. Therapy participation measured in minutes and missed sessions.

Results:
There were no group differences in agitated behavior (average scores, peak scores, or number of clinically agitated days) between the treatment and TAU groups. For treated patients, there was no significant relationship between agitation and therapy participation (therapy minutes or missed ADL treatment sessions).

Conclusions:
This study demonstrated that agitation is not increased by delivery of structured ADL retraining during PTA and agitation did not limit therapy participation. This supports the consideration of active therapy during PTA.
Evaluation of Mitoquinone for Protecting Against Amikacin-Induced Ototoxicity in Guinea Pigs
Authors: Dirain Carolyn O. , Ng Maria Raye Ann V. , Milne-Davies Bailey , Joseph Jerin K. , Antonelli Patrick J. 
Published: November 2017

Hypothesis:
Mitoquinone (MitoQ) attenuates amikacin ototoxicity in guinea pigs.

Background:
MitoQ, a mitochondria-targeted derivative of the antioxidant ubiquinone, has improved bioavailability and demonstrated safety in humans. Thus, MitoQ is a promising therapeutic approach for protecting against amikacin-induced ototoxicity.

Methods:
Both oral and subcutaneous administrations of MitoQ were tested. Amikacin-treated guinea pigs (n = 12–18 per group) received water alone (control) or MitoQ 30 mg/l-supplemented drinking water; or injected subcutaneously with 3 to 5 mg/kg MitoQ or saline (control). Auditory brainstem responses and distortion product otoacoustic emissions were measured before MitoQ or control solution administration and after amikacin injections. Cochlear hair cell damage was assessed using scanning electron microscopy and Western blotting.

Results:
With oral administration, animals that received 30 mg/l MitoQ had better hearing than controls at only 24 kHz at 3-week (p = 0.017) and 6-week (p = 0.027) post-amikacin. With subcutaneous administration, MitoQ-injected guinea pigs had better hearing than controls at only 24 kHz, 2-week post-amikacin (p = 0.013). Distortion product otoacoustic emission (DPOAE) amplitudes were decreased after amikacin injections, but were not different between treatments (p > 0.05). Electron microscopy showed minor difference in outer hair cell loss between treatments. Western blotting demonstrated limited attenuation of oxidative stress in the cochlea of MitoQ-supplemented guinea pigs.

Conclusions:
Oral or subcutaneous MitoQ provided limited protection against amikacin-induced hearing loss and cochlear damage in guinea pigs. Other strategies for attenuating aminoglycoside-induced ototoxicity should be explored.
Quality of life related to oral, subcutaneous, and intravenous biologic treatment of inflammatory bowel disease: a time trade-off study
Authors: Holko Przemysław , Kawalec Paweł , Mossakowska Małgorzata 
Published: November 2017

Objectives
Novel oral treatments (including biologics) of inflammatory bowel disease (IBD) are emerging. Apart from improvement of health, treatment convenience may be of value to patients. This ‘process utility’ can be estimated under the quality-of-life framework. We investigated the process utility associated with subcutaneous and intravenous biologic treatments compared with a hypothetical oral biologic treatment of IBD.

Materials and methods
A time trade-off study to estimate utilities for health states among adult patients with IBD was carried out. Respondents rated the anchor state (no description of the route of administration; the reference) and three states described: the once-daily oral, 2-weekly subcutaneous, and 8-weekly intravenous administration of biologic treatment for advanced IBD.

Results
Data from 127 respondents (age, 34.4 years; women, 52.9%) were collected. The oral state was valuated higher than the anchor state more frequently than subcutaneous and intravenous states (P=0.001). The process utility of the oral state adjusted for confounders was estimated at 0.147 (95% confidence interval: 0.087–0.208) and 0.164 (95% confidence interval: 0.096–0.233) in comparison with subcutaneous and intravenous states, respectively. The results were consistent across the respondents irrespective of their characteristics and unaffected by the change in the assumptions of data analysis.

Conclusion
Oral administration is preferred over the available routes of administration of biologics by patients with IBD. The utility gains from oral treatment were significant, indicating higher value of that treatment within a cost-utilitarian approach. The additional process-related benefit can justify higher expenditures for the research of oral biologics.
Clinical Significance of Biofilm on Silicone Tubes Removed From Patients With Nasolacrimal Duct Stenosis
Authors: Kim Sung Hyun , Park Choul Yong , Hwang Sang Won , Chang Minwook 
Published: November 2017

Purpose:
To determine the relationship between the optical density of biofilms on silicone tubes and surgical outcomes.

Methods:
A total of 43 silicone tubes from 33 patients with nasolacrimal duct stenosis were enrolled at 6 months after bicanalicular silicone tube intubation. The removed silicone tubes were divided into 2 segments. One segment of silicone tube was cultured while the other segment was used to measure optical density of biofilm. Each segment was divided into 3 pieces according to average normal human nasolacrimal anatomy. The first piece was located from puncta to lacrimal sac. The second piece was inside the nasolacrimal duct. The third piece was in the nasal cavity. Surgical outcome was evaluated at postoperative 12 months based on Munk score and fluorescein dye disappearance test.

Results:
A total of 31 (72.1%) patients were surgically successful while 12 (27.9%) patients had surgical failure with persistent epiphora. In the second piece of silicone tube, the mean optical density of biofilm was 0.2654 nm in the surgical success group and 0.4472 nm in the surgical failure group. These results showed statistically significant (P < 0.01) difference. The most frequently isolated organism was Staphylococcus aureus in the surgical success group (7 of 31 patients, 22.6%). It was Pseudomonas aeruginosa in the surgical failure group (6 of 12 patients, 50%).

Conclusion:
This is the first study that determines the relationship between biofilm on silicone tube and surgical outcome. Biofilm formed on silicone tubes in nasolacrimal duct might cause surgical failure.
Transmission patterns of hyper-endemic multi-drug resistant Klebsiella pneumoniae in a Cambodian neonatal unit: a longitudinal study with whole genome sequencing
Authors: Smit Pieter W. , Stoesser Nicole , Pol Sreymom , van Kleef Esther , Oonsivilai Mathupanee , Tan Pisey , Neou Leakhena , Turner Claudia , Turner Paul , Cooper Ben S 
Published: November 2017

AbstractBackgroundKlebsiella pneumoniae is an important and increasing cause of life-threatening disease in hospitalised neonates. Third generation cephalosporin resistance (3GC-R) is frequently a marker of multi-drug resistance, and can complicate management of infections. 3GC-R K. pneumoniae is hyper-endemic in many developing country settings, but its epidemiology is poorly understood and prospective studies of endemic transmission are lacking. We aimed to determine the transmission dynamics of 3GC-R K. pneumoniae in a newly opened neonatal unit (NU) in Cambodia.MethodsWe performed a prospective longitudinal study between September and November 2013. Rectal swabs from 37 consented patients were collected upon NU admission and every three days thereafter. Morphologically different colonies from swabs growing cefpodoxime-resistant K. pneumoniae were selected for whole-genome sequencing (WGS).Results32/37 (86%) patients screened positive for 3GC-R K. pneumoniae and 93 colonies from 119 swabs were sequenced. Isolates were resistant to a median of six (range 3-9) antimicrobials. WGS revealed high diversity; pairwise distances between isolates from the same patient were either 0-1 SNV or >1,000 SNVs; 19/32 colonized patients harboured K. pneumoniae colonies differing by >1000 SNVs. Diverse lineages accounted for 18 probable importations to the NU and nine probable transmission clusters involving 19/37 (51%) of screened patients. Median cluster size was 5 patients (range 3-9).ConclusionsThe epidemiology of 3GC-R K. pneumoniae was characterised by multiple introductions and a dense network of cross-infection, with half of screened neonates part of a transmission cluster. Efforts to reduce the 3GC-R K. pneumoniae disease burden should consider targeting both processes.
Phylogenomics of montane frogs of the Brazilian Atlantic Forest supports a scenario of isolation in sky islands followed by relative climatic stability
Authors: Pie Marcio R. , Faircloth Brant C. , Ribeiro Luiz F. , Bornschein Marcos R. , McCormack John E. 
Published: November 2017

AbstractDespite encompassing a relatively small geographical area, montane regions harbor disproportionately high levels of species diversity and endemism. Yet, relatively little is known about the evolutionary mechanisms ultimately leading to montane diversity. In this study, we use target capture of ultraconserved elements to investigate the phylogenetic relationships and diversification patterns of Melanophryniscus (Bufonidae) and Brachycephalus (Brachycephalidae), two frog genera that occur in sky islands of the southern Atlantic Forest of Brazil. Specifically, we test whether diversification of montane species in these genera can be explained by a single climatic shift leading to isolation in sky islands, followed by relative climatic stability that maintained populations in allopatry. In both genera, the topologies inferred using concatenation and coalescent-based methods were concordant and had strong nodal support, except for a few recent splits. These recent splits tended to be supported by more informative loci (those with higher average bootstrap support), suggesting that, while individual trees may be well resolved, the relationships they recover are being obscured by non-informative data. Divergence dating of a combined dataset using both genera is consistent with concordant timing of their diversification. These results support the scenario of diversification-by-isolation in sky islands, and suggest that allopatry due to climatic gradients in montane regions are an important mechanism for generating species diversity and endemism in these regions.
The Functional Connectivity between the Locust Leg Pattern Generating Networks and the Subesophageal Ganglion Higher Motor Center
Authors: Knebel Daniel , Rillich Jan , Nadler Leonard , Pflueger Hans-Joachim , Ayali Amir 
Published: November 2017

AbstractInteractions among different neuronal circuits are essential for adaptable coordinated behavior. Specifically, higher motor centers and central pattern generators (CPGs) induce rhythmic leg movements that act in concert in the control of locomotion. Here we explored the relations between the subesophageal ganglion (SEG) and thoracic leg CPGs in the desert locust. Backfill staining revealed about 300 SEG descending interneurons (DINs) and some overlap with the arborization of DINs and leg motor neurons. In accordance, inin-vitropreparations, electrical stimulation applied to the SEG excited these neurons, and in some cases also induced CPGs activity. Additionally, we found that the SEG regulates the coupling pattern among the CPGs: when the CPGs were activated pharmacologically, inputs from the SEG were able to synchronize contralateral CPGs. This motor output was correlated to the firing of SEG descending and local interneurons. Altogether, these findings point to a role of the SEG in both activating leg CPGs and in coordinating their oscillations, and suggest parallels between the SEG and the brainstem of vertebrates.
Interaction of intercultural service encounters
Authors: Ihtiyar Ali 
Published: November 2017

Purpose
The purpose of this paper is to better understand the impact of intercultural communication and personality on customer satisfaction and loyalty in grocery retailing. In this endeavour, this study illustrates the unique context of intercultural communication to highlight several improvements in the literature and to encourage the advancement of the intercultural communication in the literature.

Design/methodology/approach
To initiate the research, a survey approach was taken. In total, 681 questionnaires were returned out of 1,100 that were distributed within selected grocery retailers in Klang Valley, Malaysia. The measurement of the constructs and their interrelationships is examined based on partial least square-structural equation modelling.

Findings
The findings validate the proposed framework with statistically significant relationships among all constructs. Furthermore, it exposes additional insights into some practical and conceptual solutions for addressing the intercultural communication of culturally diverse encounters in the Malaysian grocery retail industry. These contributions postulate an impetus for future research in various service settings.

Originality/value
Based on role, interdependence and cognitive consistency theory, this study assesses the role of the personality of grocery retail consumers on intercultural communication competence (ICC) and its impact on inter-role congruence (IRC) and interaction comfort (IAC). It is anticipated that by filling this knowledge gap, the research will assist in strengthening retail communication strategies, which require intercultural communication adjustments in a multicultural business environment. The ICC is expected to improve the retail industry competitiveness when it positively influences IRC and IAC among customers.
How website quality affects online impulse buying
Authors: Akram Umair , Hui Peng , Kaleem Khan Muhammad , Tanveer Yasir , Mehmood Khalid , Ahmad Wasim 
Published: November 2017

PurposeThe purpose of this paper is to investigate the impact of website quality on online impulse buying behavior (OIBB) in China, and assess the moderating roles of sales promotion and credit card use.Design/methodology/approachAn online and personal survey from 1,161 online shoppers belonging to three big cities of China – Beijing, Shanghai, and Nanjing – was conducted. A random sampling technique was utilized for data collection. Data were analyzed using validity and reliability tests, confirmatory factor analysis, and structural equation modeling.FindingsThree major findings discovered are: first, the website quality positively affects the OIBB; second, the sales promotion significantly influences OIBB and acts as a strong moderator on the relationship between website quality and online impulse buying; and third, the online impulse purchases are positively influenced by use of credit card, and the use of credit card enhances the relationship between website quality and online impulse buying.Research limitations/implicationsFirst, the website quality positively affects the OIBB; second, the sales promotion significantly influences OIBB and acts as a strong moderator in the relationship between website quality and online impulse buying; and third, online impulse purchases are positively influenced by credit card use. Moreover, credit card use enhances the relationship between website quality and online impulse buying.Originality/valueThis research is the first to investigate the relationship between website quality and OIBB in China, with sales promotion and credit card use as moderators.
An improved algorithm for personalized recommendation on MOOCs
Authors: Wang Yuqin , Liang Bing , Ji Wen , Wang Shiwei , Chen Yiqiang 
Published: November 2017

Purpose
In the past few years, millions of people started to acquire knowledge from the Massive Open Online Courses (MOOCs). MOOCs contain massive video courses produced by instructors, and learners all over the world can get access to these courses via the internet. However, faced with massive courses, learners often waste much time finding courses they like. This paper aims to explore the problem that how to make accurate personalized recommendations for MOOC users.

Design/methodology/approach
This paper proposes a multi-attribute weight algorithm based on collaborative filtering (CF) to select a recommendation set of courses for target MOOC users.

Findings
The recall of the proposed algorithm in this paper is higher than both the traditional CF and a CF-based algorithm – uncertain neighbors’ collaborative filtering recommendation algorithm. The higher the recall is, the more accurate the recommendation result is.

Originality/value
This paper reflects the target users’ preferences for the first time by calculating separately the weight of the attributes and the weight of attribute values of the courses.