bluuebunny/crossref_metadata_2025_split huggingface dataset:
International Retrospective Chart Review of Treatment Patterns in Severe Familial Mediterranean Fever, Tumor Necrosis Factor Receptor–Associated Periodic Syndrome, and Mevalonate Kinase Deficiency/Hyperimmunoglobulinemia D Syndrome
Authors: Ozen Seza , Kuemmerle‐Deschner Jasmin B. , Cimaz Rolando , Livneh Avi , Quartier Pierre , Kone‐Paut Isabelle , Zeft Andrew , Spalding Steve , Gul Ahmet , Hentgen Veronique , Savic Sinisa , Foeldvari Ivan , Frenkel Joost , Cantarini Luca , Patel Dony , Weiss Jeffrey , Marinsek Nina , Degun Ravi , Lomax Kathleen G. , Lachmann Helen J. 
Published: October 2016

ObjectivePeriodic fever syndrome (PFS) conditions are characterized by recurrent attacks of fever and localized inflammation. This study examined the diagnostic pathway and treatments at tertiary centers for familial Mediterranean fever (FMF), tumor necrosis factor receptor–associated periodic syndrome (TRAPS), and mevalonate kinase deficiency (MKD)/hyperimmunoglobulinemia D syndrome (HIDS).MethodsPFS specialists at medical centers in the US, the European Union, and the eastern Mediterranean participated in a retrospective chart review, providing de‐identified data in an electronic case report form. Patients were treated between 2008 and 2012, with at least 1 year of followup; all had clinical and/or genetically proven disease and were on/eligible for biologic treatment.ResultsA total of 134 patients were analyzed: FMF (n = 49), TRAPS (n = 47), and MKD/HIDS (n = 38). Fever was commonly reported as severe across all indications. Other frequently reported severe symptoms were serositis for FMF patients and elevated acute‐phase reactants and gastrointestinal upset for TRAPS and MKD/HIDS. A long delay from disease onset to diagnosis was seen within TRAPS and MKD/HIDS (5.8 and 7.1 years, respectively) compared to a 1.8‐year delay in FMF patients. An equal proportion of TRAPS patients first received anti–interleukin‐1 (anti‐IL‐1) and anti–tumor necrosis factor (anti‐TNF) biologic agents, whereas IL‐1 blockade was the main choice for FMF patients resistant to colchicine and MKD/HIDS patients. For TRAPS patients, treatment with anakinra versus anti‐TNF treatments as first biologic agent resulted in significantly higher clinical and biochemical responses (P = 0.03 and P < 0.01, respectively). No significant differences in responses were observed between biologic agents among other cohorts.ConclusionReferral patterns and diagnostic delays highlight the need for greater awareness and improved diagnostics for PFS. This real‐world treatment assessment supports the need for further refinement of treatment practices.
Subfertility in Women With Rheumatoid Arthritis and the Outcome of Fertility Assessments
Authors: Brouwer Jenny , Fleurbaaij Rosalie , Hazes Johanna M. W. , Dolhain Radboud J. E. M. , Laven Joop S. E. 
Published: October 2016

ObjectiveSubfertility is frequently encountered among female rheumatoid arthritis (RA) patients and has been associated with disease activity and antirheumatic drugs. However, little is known about the results of the fertility assessments in these women. Our aim was to study the outcome of fertility assessments in subfertile women with RA.MethodsA cross‐sectional study was performed in a nationwide cohort of female RA patients who were pregnant or trying to conceive between 2002 and 2010 (Pregnancy‐Induced Amelioration of Rheumatoid Arthritis Study). Patients who had given consent for future contact (n = 260) received a questionnaire on reproductive history, fertility examinations, and fertility treatments. Medical files were obtained from attending gynecologists.ResultsA completed questionnaire was returned by 178 women (68%), of whom 96% had ended their efforts to conceive. Eighty‐two subjects (46%) had at least 1 subfertile episode, and for 61 women a diagnosis for subfertility was available. Unexplained subfertility (48%) and anovulation (28%) were the most common gynecologic diagnoses, and both occurred more often in RA patients than reported in the general population. Women with unexplained subfertility more often used nonsteroidal antiinflammatory drugs (NSAIDs) during the periconceptional period. Seventeen percent of all pregnancies were conceived after fertility treatments. Fertility treatments had equal or higher pregnancy rates in RA compared to other subfertile populations.ConclusionUnexplained subfertility is more often diagnosed in subfertile female RA patients than in the general population, and is related to periconceptional NSAID use. Despite the higher incidence of subfertility in women with RA, the outcome of fertility treatments in these women appears favorable.
Task distribution, work environment, and perceived health discomforts among Indian ceramic workers
Authors: Majumder Joydeep , Shah Priyanka , Bagepally Bhavani S. 
Published: October 2016

BackgroundThe study examined the work environment of Indian ceramics workers and assessed associations between work hazards, work category, and self‐reported symptoms.MethodsThe multi‐method ergonomic review technique (MMERT) checkpoints was used for work analysis and prevalence of self‐reported symptoms among 329 male workers.ResultsAmbient temperature and relative humidity in ceramic industries were 39.9°C and 17.4% respectively. Musculoskeletal discomfort was observed as a primary complaint; especially lower extremity pain (45%). Load handlers and machine operators had the highest levels of work hazards, including high skill requirement, strenuous work posture, poor commitment by the organization. Poor job autonomy, task clarity, hot workplace, inappropriate workplace design, inadequate auxiliary support, and mental overload were significantly associated with self‐reported symptoms (P < 0.001).ConclusionWork categories are associated with work hazards and may lead to various health symptoms among ceramic workers. Control of workplace hazards may lower rates of symptoms and thus may lead to improved health, productivity, and well‐being. Am. J. Ind. Med. 59:1145–1155, 2016. © 2016 Wiley Periodicals, Inc.
Palladium‐Catalyzed Heterocyclization: A Carbon‐Centered Approach
Authors: Phillips David , France David J. 
Published: October 2016

AbstractHeterocycles are some of the most important and widely used motifs in synthetic and medicinal chemistry. It is therefore not surprising that the synthesis of heterocycles is a rich area of chemical research. Catalytic heterocyclization that makes use of heteroatomic nucleophiles, such as oxygen and nitrogen, is one such powerful strategy. This Focus Review considers an alternative approach that uses carbon‐based nucleophiles that are generated during palladium‐catalyzed heterocyclization reactions. This complimentary method allows access to a range of useful and otherwise‐inaccessible targets. Occurring through a range of different mechanisms, the utility of this approach can be seen in the wide range of transformations that can be undertaken, along with its repeated application in the synthesis of complex molecules.
Integrating feeding behavior, ecological data, and DNA barcoding to identify developmental differences in invertebrate foraging strategies in wild white‐faced capuchins (Cebus capucinus)
Authors: Mallott Elizabeth K. , Garber Paul A. , Malhi Ripan S. 
Published: October 2016

AbstractObjectivesInvertebrate foraging strategies in nonhuman primates often require complex extractive foraging or prey detection techniques. As these skills take time to master, juveniles may have reduced foraging efficiency or concentrate their foraging efforts on easier to acquire prey than adults.Materials and methodsWe use DNA barcoding, behavioral observations, and ecological data to assess age‐based differences in invertebrate prey foraging strategies in a group of white‐faced capuchins (Cebus capucinus) in northeastern Costa Rica. Invertebrate availability was monitored using canopy traps and sweep netting. Fecal samples were collected from adult female, adult male, and juvenile white‐faced capuchins (n = 225).COImtDNA sequences were compared with known sequences in GenBank and the Barcode of Life Database.ResultsFrequencies of Lepidoptera and Hymenoptera consumption were higher in juveniles than in adults. A significantly smaller proportion of juvenile fecal samples contained Gryllidae and Cercopidae sequences, compared with adults (0% and 4.2% vs. 4.6% and 12.5%), and a significantly larger proportion contained Tenthredinidae, Culicidae, and Crambidae (5.6%, 9.7%, and 5.6% vs. 1.3%, 0.7%, and 1.3%). Juveniles spent significantly more time feeding and foraging than adults, and focused their foraging efforts on prey that require different skills to capture or extract. Arthropod availability was not correlated with foraging efficiency, and the rate of consumption of specific orders of invertebrates was not correlated with the availability of those same taxa.DiscussionOur data support the hypothesis that juveniles are concentrating their foraging efforts on different prey than adults, potentially focusing their foraging efforts on more easily acquired types of prey.
Repair of caudal septal deviation: the fishing line technique
Authors: Yaniv Dan , Hadar Tuvia , Hod Roe , Lansberg Roee , Koren Ilan , Yaniv Eitan 
Published: October 2016

BackgroundRepair of caudal septal deviation using currently described methods is challenging technically. The aim of this work is to describe a novel and simple technique for the treatment of caudal septal deviations that protects the nasal tip, by fixating of cartilage to the columella.MethodsAll patients with caudal septal deviation operated on between June 2008 to November 2013 in 2 major medical centers were operated using the “fishing line technique.” Patient satisfaction was recorded by a standard questionnaire (16‐item Sino‐Nasal Outcome Test [SNOT‐16]), before and after surgery. The fishing line technique was performed in 63 patients with a severe caudal septal deviation of which 14 also had rhinoplasty. A mucoperichondrial flap was elevated on either side of the damaged septal cartilage. The cartilage was excised and remodeled into a straight sheet, and then repositioned between the mucoperichondrial flaps, and fixed to the septal columella.ResultsMean age of the study group was 36 years. Follow‐up ranged from 24 to 70 months. At the last follow‐up, the septum was straight in all cases, with no deviation from the nostrils to the choana. Good airway was found in 53 patients. Eight patients had partial turbinate hypertrophy with an impaired airway, and 2 had severe turbinate hypertrophy. SNOT‐16 mean score improved from 27 to 10 (p < 0.001). All patients were satisfied with the aesthetic outcome.ConclusionThe fishing‐line technique for severe caudal septum deviations is easy to perform and yields satisfactory anatomic and aesthetic results.
The Origin of Improved Electrical Double‐Layer Capacitance by Inclusion of Topological Defects and Dopants in Graphene for Supercapacitors
Authors: Chen Jiafeng , Han Yulei , Kong Xianghua , Deng Xinzhou , Park Hyo Ju , Guo Yali , Jin Song , Qi Zhikai , Lee Zonghoon , Qiao Zhenhua , Ruoff Rodney S. , Ji Hengxing 
Published: October 2016

AbstractLow‐energy density has long been the major limitation to the application of supercapacitors. Introducing topological defects and dopants in carbon‐based electrodes in a supercapacitor improves the performance by maximizing the gravimetric capacitance per mass of the electrode. However, the main mechanisms governing this capacitance improvement are still unclear. We fabricated planar electrodes from CVD‐derived single‐layer graphene with deliberately introduced topological defects and nitrogen dopants in controlled concentrations and of known configurations, to estimate the influence of these defects on the electrical double‐layer (EDL) capacitance. Our experimental study and theoretical calculations show that the increase in EDL capacitance due to either the topological defects or the nitrogen dopants has the same origin, yet these two factors improve the EDL capacitance in different ways. Our work provides a better understanding of the correlation between the atomic‐scale structure and the EDL capacitance and presents a new strategy for the development of experimental and theoretical models for understanding the EDL capacitance of carbon electrodes.
Netzwerke aus Supertetraedern und Lithiumionenbeweglichkeit in Li2SiP2 und LiSi2P3
Authors: Haffner Arthur , Bräuniger Thomas , Johrendt Dirk 
Published: October 2016

AbstractDie neuen Phosphidosilicate Li2SiP2 und LiSi2P3 wurden aus den Elementen bei 1123 K synthetisiert und durch Einkristallstrukturanalyse charakterisiert. Li2SiP2 (I41/acd, Z=32, a=12.111(1) Å, c=18.658(2) Å) enthält zwei sich durchdringende Diamant‐analoge Tetraedernetzwerke aus eckenverknüpften T2‐Supertetraedern [(SiP4/2)4]. In der komplexen Struktur von LiSi2P3 (I41/a, Z=100, a=18.4757(3) Å, c=35.0982(6) Å) liegen Sphalerit‐analoge sich durchdringende Netzwerke aus T4‐ und T5‐Supertetraedern mit je einer gemeinsamen SiP4‐Gruppe vor. Lithium ist in den Zwischenräumen der Supertetraeder durch vier bis sechs Phosphoratome koordiniert. Temperaturabhängige 7Li‐MAS‐NMR‐Spektren deuten auf eine hohe Beweglichkeit der Li+‐Ionen mit geringen Aktivierungsenergien von 0.1 eV für Li2SiP2 und 0.07 eV für LiSi2P3.
C(sp3)−H Oxidative Addition and Transfer Hydrogenation Chemistry of a Titanium(II) Synthon: Mimicry of Late‐Metal Type Reactivity
Authors: Aguilar‐Calderón J. Rolando , Metta‐Magaña Alejandro J. , Noll Bruce , Fortier Skye 
Published: October 2016

AbstractTwo‐electron reduction of the TiIV compound (ketguan)(ImDippN)Ti(OTf)2 (3) gives the arene‐masked complex (ketguan)(η6‐ImDippN)Ti (1) in excellent yield. Upon standing in solution, 1 converts to a TiIV metallacycle (4) through dehydrogenation of a pendant isopropyl group. Spectroscopic evidence shows this transformation initially proceeds via the oxidative addition of a C(sp3)−H bond and can be reversed upon exposure of 4 to H2. Interestingly, treatment of 1 with cyclohexene gives cyclohexane and 4 via a titanium‐mediated transfer hydrogenation reaction, a process that can be extended to catalytically hydrogenate other unsaturated hydrocarbons under mild conditions. These results, rare for the early‐metals, suggest 1 possesses chemical characteristics reminiscent of noble, late‐metals.
Vesikel in der Natur und im Labor: die Aufklärung der biologischen Eigenschaften und die Synthese zunehmend komplexer synthetischer Vesikel
Authors: Fernandez‐Trillo Francisco , Grover Liam M. , Stephenson‐Brown Alex , Harrison Paul , Mendes Paula M. 
Published: October 2016

AbstractDie wichtige Rolle von Vesikeln in vielen Bereichen der Zellfunktion ist gut bekannt, aber erst seit kurzem offenbart sich mithilfe neuer, komplexerer Bildgebungsverfahren ihre Allgegenwart in der Natur. Während die biologischen Eigenschaften von Vesikeln und ihre physiologischen Funktionen immer besser verstanden werden, werden auch vermehrt sehr elegante, künstliche Vesikel für eine Reihe technischer Anwendungen und die Grundlagenforschung entwickelt. Hier wollen wir den Stand der Technik von biologischen und synthetischen Vesikeln darstellen und ihre biologischen Eigenschaften in Zusammenhang mit aktuellen Syntheseentwicklungen bringen, um so einen Überblick über diese komplexen, rasch aufstrebenden Fachgebiete zu geben. Darüber hinaus werden die Herausforderungen und Möglichkeiten für die zukünftige biologische und präparative Entwicklung von Vesikeln präsentiert.
Das Zusammenspiel zwischen einer multifunktionalen Dehydratase‐Domäne und einer C‐Methyltransferase bewirkt die Doppelbindungsverschiebung in der Ambruticin‐Biosynthese
Authors: Berkhan Gesche , Merten Christian , Holec Claudia , Hahn Frank 
Published: October 2016

AbstractDie Doppelbindungsverschiebung ist eine wichtige Modifizierung während der Polyketidbiosynthese. Insbesondere für cis‐AT‐PKS vom Typ I ist nur wenig über die enzymatischen Mechanismen bekannt. Wir präsentieren unsere In‐vitro‐Studien zur Doppelbindungsverschiebung während der Ambruticin‐Biosynthese. Die multifunktionale AmbDH4‐Domäne katalysiert aufeinander folgende Dehydratisierung, Epimerisierung und Enoylisomerisierung. Das erhaltene 3‐Enthioat wird durch α‐Methylierung, katalysiert durch die C‐Methyltransferase AmbM, aus dem Gleichgewicht entfernt. Dieser thermodynamisch eigentlich ungünstige Prozess wird jedoch durch die hohe und aufeinander abgestimmte Substratspezifität der beteiligten Enzyme ermöglicht. AmbDH4 ist eng verwandt mit DH‐Domänen, wobei erste mechanistische Studien vermuten lassen, dass die Doppelbindungsisomerisierung, ähnlich wie bei EI‐Domänen aus trans‐AT‐PKS, über die Verschiebung eines einzelnen Protons verläuft.
A Ruthenium(III)–Oxyl Complex Bearing Strong Radical Character
Authors: Shimoyama Yoshihiro , Ishizuka Tomoya , Kotani Hiroaki , Shiota Yoshihito , Yoshizawa Kazunari , Mieda Kaoru , Ogura Takashi , Okajima Toshihiro , Nozawa Shunsuke , Kojima Takahiko 
Published: October 2016

AbstractProton‐coupled electron‐transfer oxidation of a RuII−OH2 complex, having an N‐heterocyclic carbene ligand, gives a RuIII−O. species, which has an electronically equivalent structure of the RuIV=O species, in an acidic aqueous solution. The RuIII−O. complex was characterized by spectroscopic methods and DFT calculations. The oxidation state of the Ru center was shown to be close to +3; the Ru−O bond showed a lower‐energy Raman scattering at 732 cm−1 and the Ru−O bond length was estimated to be 1.77(1) Å. The RuIII−O. complex exhibits high reactivity in substrate oxidation under catalytic conditions; particularly, benzaldehyde and the derivatives are oxidized to the corresponding benzoic acid through C−H abstraction from the formyl group by the RuIII−O. complex bearing a strong radical character as the active species.
DNA‐Accelerated Catalysis of Carbene‐Transfer Reactions by a DNA/Cationic Iron Porphyrin Hybrid
Authors: Rioz‐Martínez Ana , Oelerich Jens , Ségaud Nathalie , Roelfes Gerard 
Published: October 2016

AbstractA novel DNA‐based hybrid catalyst comprised of salmon testes DNA and an iron(III) complex of a cationic meso‐tetrakis(N‐alkylpyridyl)porphyrin was developed. When the N‐methyl substituents were placed at the ortho position with respect to the porphyrin ring, high reactivity in catalytic carbene‐transfer reactions was observed under mild conditions, as demonstrated in the catalytic enantioselective cyclopropanation of styrene derivatives with ethyl diazoacetate (EDA) as the carbene precursor. A remarkable feature of this catalytic system is the large DNA‐induced rate acceleration observed in this reaction and the related dimerization of EDA. It is proposed that high effective molarity of all components of the reaction in or near the DNA is one of the key contributors to this unique reactivity. This study demonstrates that the concept of DNA‐based asymmetric catalysis can be expanded into the realm of organometallic chemistry.
Aromatic Osmacyclopropenefuran Bicycles and Their Relevance for the Metal‐Mediated Hydration of Functionalized Allenes
Authors: Batuecas María , Castro‐Rodrigo Ruth , Esteruelas Miguel A. , García‐Yebra Cristina , López Ana M. , Oñate Enrique 
Published: October 2016

AbstractThe aromatic osmacyclopropenefuran bicycles [OsTp{κ3‐C1,C2,O‐(C1H2C2CHC(OEt)O)}(PiPr3)]BF4 (Tp=hydridotris(1‐pyrazolyl)borate) and [OsH{κ3‐C1,C2,O‐(C1H2C2CHC(OEt)O)}(CO)(PiPr3)2]BF4, with the metal fragment in a common vertex between the fused three‐ and five‐membered rings, have been prepared via the π‐allene intermediates [OsTp(η2‐CH2=CCHCO2Et)(OCMe2)(PiPr3)]BF4 and [OsH(η2‐CH2=CCHCO2Et)(CO)(OH2)(PiPr3)2]BF4, and their aromaticity analyzed by DFT calculations. The bicycle containing the [OsH(CO)(PiPr3)2]+ metal fragment is a key intermediate in the [OsH(CO)(OH2)2(PiPr3)2]BF4‐catalyzed regioselective anti‐Markovnikov hydration of ethyl buta‐2,3‐dienoate to ethyl 4‐hydroxycrotonate.
Pentaindenocorannulene: Properties, Assemblies, and C60 Complex
Authors: Lampart Samuel , Roch Loïc M. , Dutta Amit K. , Wang Yujia , Warshamanage Rangana , Finke Aaron D. , Linden Anthony , Baldridge Kim K. , Siegel Jay S. 
Published: October 2016

AbstractPentaindenocorannulene (C50H20 , 1), a deep bowl polynuclear aromatic hydrocarbon, accepts 4 electrons, crystallizes in columnar bowl‐in‐bowl assemblies and forms a nested C60@12 complex. Spectra, structures and computations are presented.
Alkyne cellulose for Huisgen [3 + 2] cycloaddition with azido‐terminated targets
Authors: Cao Liangcheng , Wang Yuechuan 
Published: October 2016

ABSTRACTAzido‐grafted cellulose has been reported widely applied for further functionalization by click chemistry. As an alternative method, we proposed alkyne‐grafted cellulose as a prototype molecule for Huisgen [3 + 2] cycloaddition with azido‐terminated target compounds. Alkyne cellulose was synthesized by acylation with prop‐2‐ynyl 5‐chloro‐5‐oxopentanoate and, subsequently cycloaddition with 4‐aminophenylazide, ethyl 2‐azidoacetate, and (S)‐2‐(Azidomethyl)‐1‐(tert‐butoxycarbonyl)pyrrolidine (Boc‐pyrrolidine azide) to form triazole cellulose in a click manner. The reactions were confirmed qualitatively by Fourier transform infrared and NMR spectroscopy and analyzed quantitatively with elemental analysis data. The results show that a degree of substitution of up to 1.91 was obtained for esterification and, in most cases, was preferred completely in a selective way for the primary hydroxyl groups at the O‐6 position and partially at the O‐2 and O‐3 positions. Cycloaddition conversions were found as high as 0.95, 0.99, and 0.99 for aniline–triazole cellulose, acetate–triazole cellulose, and Boc‐pyrrolidine‐triazole cellulose, respectively. Both esterification and cycloaddition were undertaken under mild conditions without additional heating. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44410.
Polymorphisms in the F Pocket of HLA–B27 Subtypes Strongly Affect Assembly, Chaperone Interactions, and Heavy‐Chain Misfolding
Authors: Guiliano David B. , North Helen , Panayoitou Eleni , Campbell Elaine C. , McHugh Kirsty , Cooke Fiona G. M. , Silvestre Marine , Bowness Paul , Powis Simon J. , Antoniou Antony N. 
Published: October 2016

ObjectiveHLA–B27 is associated with the inflammatory spondyloarthritides (SpA), although subtypes HLA–B*27:06 and HLA–B*27:09 are not. These subtypes differ from the HLA–B*27:05 disease‐associated allele primarily at residues 114 and 116 of the heavy chain, part of the F pocket of the antigen‐binding groove. Dimerization of HLA–B27 during assembly has been implicated in disease onset. The purpose of this study was to investigate the factors that influence differences in dimerization between disease‐associated and non–disease‐associated HLA–B27 alleles.MethodsHLA–B*27:05 and mutants resembling the HLA–B*27:06 and 09 subtypes were expressed in the rat C58 T cell line, the human CEM T cell line and its calnexin‐deficient variant CEM.NKR. Immunoprecipitation, pulse–chase experiments, flow cytometry, and immunoblotting were performed to study the assembly kinetics, heavy‐chain dimerization, and chaperone associations.ResultsBy expressing HLA–B*27:05, 06‐like, and 09 alleles on a restrictive rat transporter associated with antigen processing background, we demonstrate that a tyrosine expressed at p116, either alone or together with an aspartic acid residue at p114, inhibited HLA–B27 dimerization and increased the assembly rate. F‐pocket residues altered the associations with chaperones of the early major histocompatibility complex class I folding pathway. Calnexin was demonstrated to participate in endoplasmic reticulum (ER) stress–mediated degradation of dimers, whereas the oxidoreductase ERp57 does not appear to influence dimerization.ConclusionResidues within the F pocket of the peptide‐binding groove, which differ between disease‐associated and non–disease‐associated HLA–B27 subtypes, can influence the assembly process and heavy‐chain dimerization, events which have been linked to the initiation of disease pathogenesis.