bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of SBDP145, melatonin, sLOX-1, HMGB1 and HIF-1α in preterm infants with brain injury
Authors: Cheng Sisi , Sun Xiao , Li Yanyan , Dong Yan 
Published: September 2024

Abstract
Background
Prematurity-related brain injury is a common and serious complication that has long-term effects on the survival and development of affected infants. Currently, the roles of certain biomarkers such as the protein hydrolysis product SBDP145, melatonin, soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), high mobility group box 1 protein (HMGB1), and hypoxia-inducible factor 1-alpha (HIF-1α) in prematurity-related brain injury remain not fully elucidated. Our study aims to assess the significance of SBDP145, melatonin, sLOX-1, HMGB1 and HIF-1α in preterm infants with brain injury.

Methods
135 preterm infants admitted to our hospital from January 2020 to February 2022 were selected and divided into 78 cases in a prematurity-associated brain injury group, and 57 cases in another group of preterm infants without brain injury or other diseases according to the magnetic resonance imaging results. The levels of SBDP145, melatonin, sLOX-1, HMGB1 and HIF-1α in the two groups were analyzed. The serum concentrations of SBDP145, melatonin, sLOX-1, HMGB1 and HIF-1α in newborns with different severity of ventricular hemorrhage were observed, and the levels of SBDP145, melatonin, sLOX-1, HMGB1 and HIF-1α in those with different severity of white matter brain injury were compared.

Results
The levels of SBDP145, sLOX-1, HMGB1 and HIF-1α were significantly higher in the preterm combined brain injury group than in the preterm group, and melatonin levels were significantly lower than in the preterm group(P < 0.05). The levels of SBDP145, sLOX-1, HMGB1 and HIF-1α were higher in the moderate to severe group and melatonin levels were lower in the mild group of newborns with ventricular hemorrhage (P < 0.05). The levels of SBDP145, sLOX-1, HMGB1 and HIF-1α were higher in the moderate-severe group and melatonin levels were lower in the mild group in newborns with cerebral white matter injury (P < 0.05). The independent variables were SBDP145, melatonin, sLOX-1, HMGB1, HIF-1α, and the dependent variable was the prognosis of neonates with brain injury. Univariate logistic regression analysis and multivariate logistic regression analysis were performed. The results showed that the influencing factors of newborns with brain injury were SBDP145, melatonin, sLOX-1, HMGB1, HIF-1α.

Conclusion
The levels of SBDP145, melatonin, sLOX-1, HMGB1 and HIF-1α were highly expressed in preterm newborns with brain injury, and the levels were higher when the condition of the newborns was more severe. These findings suggest the potential clinical utility of these biomarkers in predicting and monitoring brain injury in preterm infants, which could aid in early intervention and improve long-term outcomes.
Artificial intelligence derived large language model in decision-making process in uveitis
Authors: Schumacher Inès , Bühler Virginie Manuela Marie , Jaggi Damian , Roth Janice 
Published: September 2024

Abstract
Background
Uveitis is the ophthalmic subfield dealing with a broad range of intraocular inflammatory diseases. With the raising importance of LLM such as ChatGPT and their potential use in the medical field, this research explores the strengths and weaknesses of its applicability in the subfield of uveitis.

Methods
A series of highly clinically relevant questions were asked three consecutive times (attempts 1, 2 and 3) of the LLM regarding current uveitis cases. The answers were classified on whether they were accurate and sufficient, partially accurate and sufficient or inaccurate and insufficient. Statistical analysis included descriptive analysis, normality distribution, non-parametric test and reliability tests. References were checked for their correctness in different medical databases.

Results
The data showed non-normal distribution. Data between subgroups (attempts 1, 2 and 3) was comparable (Kruskal-Wallis H test, p-value = 0.7338). There was a moderate agreement between attempt 1 and attempt 2 (Cohen’s kappa, ĸ = 0.5172) as well as between attempt 2 and attempt 3 (Cohen’s kappa, ĸ = 0.4913). There was a fair agreement between attempt 1 and attempt 3 (Cohen’s kappa, ĸ = 0.3647). The average agreement was moderate (Cohen’s kappa, ĸ = 0.4577). Between the three attempts together, there was a moderate agreement (Fleiss’ kappa, ĸ = 0.4534). A total of 52 references were generated by the LLM. 22 references (42.3%) were found to be accurate and correctly cited. Another 22 references (42.3%) could not be located in any of the searched databases. The remaining 8 references (15.4%) were found to exist, but were either misinterpreted or incorrectly cited by the LLM.

Conclusion
Our results demonstrate the significant potential of LLMs in uveitis. However, their implementation requires rigorous training and comprehensive testing for specific medical tasks. We also found out that the references made by ChatGPT 4.o were in most cases incorrect. LLMs are likely to become invaluable tools in shaping the future of ophthalmology, enhancing clinical decision-making and patient care.
Fall armyworm management in a changing climate: an overview of climate-responsive integrated pest management (IPM) strategies for long-term control
Authors: Zanzana Karimou , Dannon Elie Ayitondji , Sinzogan Antonio Alain , Toffa Joelle Mehinto 
Published: September 2024

AbstractInvasive alien insects have the potential to pose a significant threat to global agriculture, with their distinctive traits enabling rapid reproduction, successful adaptation to new environments and high distribution capability. These pests can devastate crops, livestock, biodiversity and ecosystem functioning, resulting in ecological damage and substantial economic losses. Climate change plays a crucial role in driving the invasion of these pests, creating favorable conditions for their development, and negatively impacting global biodiversity. Among invasive alien insects, fall armyworm (FAW) (Spodoptera frugiperda) (JE Smith) (Lepidoptera: Noctuidae) has emerged as a major pest species, causing significant yield losses in maize cropping outside his native range. Initially, reliance on pesticides for control proved ineffective and led to pesticide resistance. Significant progress has been made in implementing integrated pest management (IPM) strategies that integrate agro-ecological and biological approaches. This review article focuses on the compilation of IPM methods, combining agro-ecological practices and biological control agents such as parasitoids and viruses, for the effective management of FAW. Approaches such as intercropping, agronomic practices, and the use of parasitoids and viruses have shown promising results in controlling FAW. This review article provides insights into successful management methods, recommendations and suggestions for the sustainable control of FAW using agro-ecological practices, biological control agents or their combination.
Clinical Utility of Molecular Tumor Board Review for Identification of Possible Germline Pathogenic Variants on Tumor Next-Generation Sequencing Reports
Authors: Rives Taylor A. , Collard James , Li Ning , Yan Donglin , Dietrich Charles S. , Miller Rachel W. , Ueland Frederick R. , Pickarski Justine , Kolesar Jill M. 
Published: September 2024

PURPOSE Tumor next-generation sequencing (NGS) testing identifies possible germline pathogenic variants (PGPVs), creating a dilemma for appropriate recognition, triage, and management. The objective of this study was to determine the clinical utility of an institutional molecular tumor board (MTB) in assessing tumor NGS reports for PGPVs. METHODS Our institutional MTB reviews all NGS reports to provide treatment and further testing recommendations, including genetic counseling referral and consideration of genetic testing (GC/GT). We studied the patients reviewed by the MTB who were recommended for GC/GT to determine the frequency of referral to a GC, germline test completion, rate of pathogenic germline variants (PGVs), factors related to PGVs, and germline conversion rate (GCR). RESULTS Of the 2,355 patients reviewed by the MTB during the study period, 609 (25.9%) had a recommendation for GC/GT. Of the 609 with a GC/GT recommendation, only 181 (29.7%) were referred for GC/GT by their treating physicians, and only 107 (17.6%) completed GT. Of the 107 patients completing GT, 29 (26%) had a confirmed PGV. The only factors significantly associated with PGVs were testing due to a PGPV and higher mean variant allele fraction on the tumor NGS. Only 40 patients with a GC/GT recommendation (14.3%) due to a PGPV completed GT; however, the GCR was 42.5% (n = 17/40). CONCLUSION The MTB review of PGPV is clinically valuable, identifying PGPV in 12% of patients undergoing tumor NGS and a GCR of 42.5%. Rates of GC/GT completion were relatively low due to under-referral by treating physicians. Given the high GCR, the authors encourage institutional algorithms to help increase GC/GT rates for patients found to have PGPV following tumor NGS testing.
Caminhos para uma gestão municipal robusta
Authors: Pazini Papi Luciana , Leite Lima Luciana , Joel Demarco Diogo , Lui Lizandro , Barbosa de Aguiar Rafael 
Published: September 2024

Objetivo: discutir a qualificação das gestões municipais brasileiras para implementar políticas públicas eficientes, discutindo as capacidades estatais em três dimensões: burocracia, planejamento e finanças públicas.
Estado da arte: desde a primeira onda de descentralização e revalorização do Estado nos anos 2000, houve avanços na profissionalização burocrática e modernização dos governos locais. No entanto, persistem desafios significativos em adaptar e aprimorar essas capacidades para lidar com problemas sociais complexos e emergentes.
Originalidade: o artigo destaca a necessidade de superar limitações estruturais, propondo mecanismos específicos para promover resiliência e adaptação nas gestões municipais, por meio da análise crítica do panorama atual e fornecimento de recomendações práticas.
Impactos: o artigo beneficia gestores públicos, ao oferecer um diagnóstico detalhado das capacidades municipais e soluções inovadoras para aprimorar a eficiência administrativa, o planejamento governamental e a gestão fiscal.
Infantile bacterial meningitis combined with sepsis caused by Streptococcus gallolyticus subspecies pasteurianus: A case report
Authors: Zou Dan , Li Fen , Jiao Shu-Li , Dong Jin-Rong , Xiao Yao-Yao , Yan Xiao-Ling , Li Yan , Ren Dan 
Published: September 2024

BACKGROUND
Streptococcus gallolyticus subspecies pasteurianus (SGSP) is a rare pathogen responsible for infant sepsis and meningitis and is potentially overlooked because it is not included in routine group B streptococcal screenings. Hence, we present a case of SGSP-induced infant meningitis and sepsis, accompanied by bronchopneumonia induced by multidrug-resistant Staphylococcus aureus (MRSA), providing insights into the identification, management, and prognosis of this bacterial infection.
CASE SUMMARY
A 45-day-old female infant presented with two episodes of high fever (maximum temperature: 39.5 °C) and two generalized grand mal seizure episodes that lasted over ten seconds and self-resolved without concomitant symptoms. Postadmission, the patient’s C-reactive protein level was 40.73 mg/L, white blood cell count was 13.42 × 109/L, neutrophil ratio was 78.4%, procalcitonin level was 7.89 μg/L, cerebrospinal fluid (CSF) white cell count was 36 × 106/L, multinucleated cell ratio was 95.2%, and protein concentration was 0.41 g/L. Blood and CSF culture revealed that the pathogen was SGSP. The bacterium was sensitive to ampicillin, furazolidone, penicillin, lincomycin, moxifloxacin, rifampicin, vancomycin, and levofloxacin but resistant to clindamycin and tetracycline. Sputum culture revealed the presence of MRSA, which was sensitive to vancomycin. The patient was diagnosed with meningitis and sepsis caused by SGSP, accompanied by bronchopneumonia induced by MRSA. Ceftriaxone (100 mg/kg/d) combined with vancomycin (10 mg/kg/dose, q6h) was given as an anti-infective treatment postadmission. After 12 days of treatment, the infant was discharged from the hospital with normal CSF, blood culture, and routine blood test results, and no complications, such as subdural effusion, were observed on cranial computed tomography. No growth retardation or neurological sequelae occurred during follow-up.
CONCLUSION
SGPSP-induced infant bacterial meningitis and sepsis should be treated with prompt blood and CSF cultures, and a sensitive antibiotic therapy to ensure a favorable prognosis.
Demographic-environmental effect on dengue outbreaks in 11 countries
Authors: Sajib Anamul Haque , Akter Sabina , Saha Goutam , Hossain Zakir 
Published: September 2024

Background
Dengue outbreaks are common in tropical or temperate countries, and climate change can exacerbate the problem by creating conditions conducive to the spread of mosquitoes and prolonging the transmission season. Warmer temperatures can allow mosquitoes to mature faster and increase their ability to spread disease. Additionally, changes in rainfall patterns can create more standing water, providing a breeding ground for mosquitoes.

Objective
The objective of this study is to investigate the correlation between environmental and demographic factors and the dissemination of dengue fever. The study will use yearly data from 2000 to 2021 from 11 countries highly affected by dengue, considering multiple factors such as dengue cases, temperatures, precipitation, and population to better understand the impact of these variables on dengue transmission.

Methods
In this research, Poisson regression (PR) and negative binomial regression (NBR) models are used to model count data and estimate the effect of different predictor variables on the outcome. Also, histogram plots and pairwise correlation plots are used to provide an initial overview of the distribution and relationship between the variables. Moreover, Goodness-of-fit tests, t-test analysis, diagnostic plots, influence plots, and residual vs. leverage plots are used to check the assumptions and validity of the models and identify any outliers or influential observations that may be affecting the results.

Results
The findings indicate that mean temperature and log(Urban) had a positive impact on dengue infection rates, while maximum temperature, log(Precipitation), and population density had a negative impact. However, minimum temperature, log(Rural), and log(Total population) did not demonstrate any significant effects on the incidence of dengue.

Conclusion
The impact of demographic-environmental factors on dengue outbreaks in 11 Asian countries is illuminated by this study. The results highlight the significance of mean temperature (Tmean), maximum temperature (Tmax), log(Urban), log(Precipitation), and population density in influencing dengue incidence rates. However, further research is needed to gain a better understanding of the role of additional variables, such as immunity levels, awareness, and vector control measures, in the spread of dengue.
Proteinuria is a clinical characteristic of intrahepatic cholestasis of pregnancy but it is not a marker of severity: A retrospective cohort study
Authors: Watad Hadel , Ohayon Aviran , Meyer Raanan , Cohen Adiel , Kassif Eran , Fisher-Bartal Michal , Yoeli Rakefet , Mazaki-Tovi Shali 
Published: September 2024

Objectives
To determine the prevalence of proteinuria in patients diagnosed with intrahepatic cholestasis of pregnancy (IHCP), and the association between the presence of proteinuria and adverse pregnancy outcomes.

Methods
This was a retrospective cohort study. The study included all pregnant patients between July 2014 and January 2022, at gestational age > 24weeks who had been diagnosed with IHCP and had completed a 24-hour protein collection. High order multifetal gestations were excluded. Patients were divided into 3 groups:1. IHCP without proteinuria (Non-proteinuric group);2. IHCP with proteinuria and normal blood pressure (Isolated proteinuria group), and 3. IHCP with proteinuria and elevated blood pressure (IHCP with preeclampsia (PET)). Primary outcome was defined as a composite maternal-fetal outcome including: preterm labor <34 weeks, arterial cord blood ph<7.1, rate of Cesarean delivery due to non-reassuring fetal monitoring. Parametric and non-parametric statistical methods were used for analysis.

Results
A total of 272 met all inclusion criteria and were included, 94 patients (34.5%) had proteinuria; of them, 67 (24.6%) had isolated proteinuria and 27 (9.9%) had PET. Demographic parameters were comparable among the groups. Patients with PET had higher rates of in-vitro fertilization (IVF) treatments, twin gestation and elevated serum creatinine and urea levels. The rate of composite adverse pregnancy outcome was higher in patients with PET compared with patients with and without proteinuria (14/27 (51.9%) vs. 18/67 (26.9%) vs. 49/178 (27.5%), respectively, p = 0.03).

Conclusions
Approximately 35% of patients with IHCP have proteinuria. The presence of PET, rather than isolated proteinuria, is associated with adverse pregnancy outcome.
Solarities: Seeking Energy Justice, After Oil Collective, Ayesha Vemuri (ed.) and Darin Barney (ed.) (2022)
Authors: Clendinning Imogen 
Published: September 2024

Review of: Solarities: Seeking Energy Justice, After Oil Collective, Ayesha Vemuri (ed.) and Darin Barney (ed.) (2022)
Minneapolis, MN: University of Minnesota Press, 92 pp.,
ISBN 978-1-51791-414-1, p\bk, USD 10.00
E-Tax Services and their Evolution: The Case of Malaysia
Authors: Kamarudin Siti Nurhazwani , Mohamad Azlinda , Nasir Noor Emilina Mohd , Abdul Malak Siti Seri Delima 
Published: September 2024

The rapid development of information and communication technology has revolutionised many areas globally, including taxation. Worldwide, the electronic tax system (e-tax) has become a necessity. Countries aim to improve efficiency of tax administration and ease for taxpayers, by incorporating technology and going digital, in their tax systems. E-tax has notable benefits, such as simplifying tax return procedures, reducing processing time and potentially improving tax compliance. In Malaysia, the tax system has also evolved over the years, incorporating digitalization. This is from the introduction of e-filing in 2006 and to the current rollout of e-invoicing. This evolution has enhanced tax filing among Malaysian corporate and individual taxpayers with 100 percent and 98.2 percent compliance respectively, standing among the top countries in Southeast Asia for compliance level in 2018-2019. However, several obstacles need to be overcome for the effective implementation of e-tax systems. Key issues such as lack of infrastructure, system integration, lack of digital literacy, taxpayer resistance and data security concerns are highlighted in this study. This paper then provides recommendations for policymakers and tax authorities to overcome these challenges to ensure a successful implementation of e-tax in Malaysia. The strategies include investment in infrastructure and technology, public education as well as strengthening collaboration with stakeholders.
Examining the Nexus Between Internships and Employability: A Bibliometric Perspective
Authors: Zakaria Zaiza Norsuriati Zainal , Awang Yunita , Nasir Noor Emilina Mohd , Taib Azuraidah 
Published: September 2024

Internship is one of the beneficial platforms for students’ engagement in the real-working experience. The internship allows the interns to explore the potential job tasks expected in their field of interest. Interns can develop their employability or job-readiness skills namely communication, teamwork and critical thinking. From the employers’ perspective, the internship provides the potential cost saving in the workflow, particularly when assistance from temporary staff is needed, gives access to a new talent pool and facilitates the recruitment of prospective full-time employees. The employability of fresh graduates promotes industrial growth, sustainability, and economic development of the country. Internships may influence employability as students’ employability skills are enhanced through internships. For a better understanding of this issue, the current study examines the evolution of research publications on the nexus between internship and employability. Using bibliometric analysis of data from the Scopus database for a period from 1975 to 2024, this study explores the trends in research publications to determine document type, subject area, publication categories by authors and countries, citation metrics and keywords. A total of 246 pertinent documents were reviewed on 14 July 2024, and the data was evaluated using Microsoft Excel, VOSviewer, and Harzing's Publish or Perish. This study provides some insights into the trends and future development of the influence of internships on employability topics in the academic literature of Business, Management, and Accounting; Economic, Econometrics and Finance and Social Sciences. The findings of the study may also be beneficial to the university management for curriculum-related purposes, and to the employers for future recruitment planning.
Supporting career awareness through job shadowing and industry site visits
Authors: Mamlok-Naaman Rachel , Blonder Ron , Lavonen Jari M. J. , Holbrook Jack , Rannikmae Miia 
Published: September 2024

Abstract
Under the SciCar project (scicar.eu), job shadowing and site visit activities were organised in science and science education research laboratories in order to support science teacher educators and PhD students in science education, having a background in science or science education research, to become aware about science careers and how they can support pre-service science teachers develop approaches for science career awareness. The following paper puts forward examples aimed at demonstrating how a job shadowing program and 2 site visits were supported for participants to become familiar with scientific research, within in the framework of Scientific Career Awareness (SciCar) European project (scicar.eu). At the end of the activities, the participants claimed that these activities supported their career awareness and they learned how to encourage their students to choose career paths in scientific fields.
Effective highly accurate time integrators for linear Klein–Gordon equations across the scales
Authors: Kropielnicka Karolina , Lademann Karolina , Schratz Katharina 
Published: September 2024

Abstract
We propose an efficient approach for time integration of Klein–Gordon equations with highly oscillatory in time input terms. The new methods are highly accurate in the entire range, from slowly varying up to highly oscillatory regimes. Our approach is based on splitting methods tailored to the structure of the input term which allows us to resolve the oscillations in the system uniformly in all frequencies, while the error constant does not grow as the oscillations increase. Numerical experiments highlight our theoretical findings and demonstrate the efficiency of the new schemes.