bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tidal Versus Intermittent Peritoneal Dialysis in Chronic Peritoneal Dialysis Patients: Randomized, Open‐Label, Prospective Control Study
Authors: Lai Jia‐Wen , Wang Charles C. N. , Chang Pao‐Hsia , Chou Che‐Yi 
Published: September 2024

ABSTRACTBackgroundTidal peritoneal dialysis (TPD) provides better fluid flow mechanics and is more comfortable for the patient, owing to fewer alarms and less pain during inflow and outflow. The long‐term characteristics of patients with TPD were not evident. In this randomized controlled follow‐up study, we aimed to explore the characteristics of patients with TPD, compared to IPD.MethodsA total of 85 patients were randomized to either IPD or 70% TPD between January 2019 and December 2020, and all patients were followed up on December 2021. The characteristics of patients between the two groups were analyzed using a t‐test or chi‐square as appropriate. The overall survival and technical survival were analyzed using Kaplan–Meier analysis.ResultsForty‐two patients were assigned to IPD, and 43 patients were assigned to TPD. The basal characteristics of patients were not different between the two groups. In an average of 16 months of follow‐up, 19 patients died, and 25 patients dropped out of peritoneal dialysis. The two groups had no difference in overall survival and technical survival. TPD was associated with high urine volume (p = 0.001), lower blood urea nitrogen (p = 0.002), lower phosphorus (p = 0.004), and fewer cycler alarms (p < 0.001). The chance of patients reporting abdominal fullness was higher in patients with TPD (p = 0.001).ConclusionIn the randomized, controlled, follow‐up study, TPD may preserve residual renal function and is associated with lower urea nitrogen and phosphorus in chronic peritoneal dialysis patients. TPD is associated with fewer cycler alarms but may increase the chance of patients reporting abdominal distension.
Paternal activation parenting and growth in children's inhibitory control across early childhood
Authors: Feldman Julia S. , Wilson Melvin N. , Shaw Daniel S. 
Published: September 2024

AbstractActivation parenting (AP) is a parenting construct derived from research and theory on paternal caregiving that includes behaviors that challenge children to approach novel situations, explore their environments, and take physical and socioemotional risks through a balance of encouragement and limit‐setting. Although components of AP have been linked to different domains of children's self‐regulation skills, comprehensive measures of AP and longitudinal research on families from low socioeconomic backgrounds are lacking. These limitations greatly constrain our understanding of the potential benefits of paternal AP for children's self‐regulation development, including the maturation of inhibitory control (IC) in early childhood. Thus, the present study tested associations between paternal AP at age 3 and growth in parent‐reported IC across ages 3–5 in a sample of low‐income, ethnically diverse fathers. Participating fathers (N = 171; 9% Black, 47% White, 8% Latinx, 61% not Latinx; mean household income = $25,145) and their children (51% female) were drawn from the Early Steps Multisite Study. AP during a clean‐up task at child age 3 years, but not a teaching task, was associated with greater growth in IC across ages 3–5 years. Implications of the current findings are presented for understanding associations between paternal AP and children's IC and broader self‐regulation skills with diverse samples of caregivers.
Judgements of identity claims vary for monoracial and biracial people
Authors: Quinn‐Jensen Elizabeth A. , Liberman Zoe 
Published: September 2024

AbstractDespite increasing racial diversity in the United States, and the particular growth of multiracial populations, questions about how children perceive others’ (bi)racial identities remain poorly understood. In two preregistered studies, we asked White and racially minoritized American children (N = 157; 4–11‐years old) and White and multiracial adults (N = 226) how acceptable it was for monoracial people (Black or White; Study 1) and/or biracial people (Black–White; Studies 1 and 2) to claim either a monoracial or biracial identity. Consistent with past research with adults, children said that monoracial people should claim (only) the monoracial identity which matched their ancestry. Judgements about biracial identity were more variable. White and multiracial adults (Study 2) reported that biracial targets could claim a racial identity that matched either or both of their parents, with biracial claims being evaluated most positively. Exploratory analyses on children's judgements about biracial people's identity claims (Study 1) revealed different patterns of development for White children and children from minoritized backgrounds. Whereas White children became more likely with age to report that all identity claims were acceptable, children from racially minoritized groups became more likely with age to endorse biracial targets who claimed a biracial identity. These findings suggest that children's own racial background and age may have a larger impact on their perceptions of biracial people's identities, compared to their perceptions of monoracial people's identities.
Intraocular osseous metaplasia in an older red‐tailed hawk (Buteo jamaicensis) 24 years following traumatic injury to the globe
Authors: Wells Taylr , Sadar Miranda , Jost Haley , Teixeira Leandro , de Linde Henriksen Michala 
Published: September 2024

AbstractAn approximately 26‐year‐old, suspected female, red‐tailed hawk (Buteo jamaicensis) was presented with a history of chronic ocular changes of the left eye likely secondary to blunt trauma resulting in blindness and phthisis bulbi. Ophthalmic evaluation of OS revealed a large intraocular mass, 3+ aqueous flare indicating anterior uveitis, and severely decreased intraocular pressure measuring 5 mmHg. Ocular ultrasound revealed an abnormal, spherical shaped and hyperechoic lens, as well as hyperechoic material or a mass lesion in the posterior segment. An enucleation procedure was performed, and histopathology of the eye revealed no signs of neoplasia but instead intraocular osseous metaplasia with bone marrow and adipose tissue replacing the lens. Similar mass lesions were found in the retina and choroid. Multiple fractures in the scleral ossicle and cartilage correlated the intraocular lesions with a blunt traumatic event. A bioresorbable disk of porcine small intestine submucosa (BioSIS Vetrix®) was incorporated to relieve tension during closure. The graft sloughed during healing process, revealing a healed wound underneath. The BioSIS was not incorporated into the wound as designed but may have facilitated healing. This is the first report of intraocular osseous metaplasia in a raptor and the use of BioSIS Vetrix® with enucleation in an avian species.
The feasibility of carotid evaluation by resident radiologists to expand access to ultrasound services
Authors: Liu Jia , Liao Mei , Zhang Hui , Ren Jie 
Published: September 2024

Aims: The purpose of our study was to determine resident radiologists’ accuracy in diagnosing carotid atherosclerotic plaque and to assess any factors leading to incorrect findings.Materials and methods: The results of preliminary carotid scanning performed by radiology residents from December 1, 2021, to August 1, 2022, were retrospectively reviewed. These scans received an instant review by experts. The discrepancy rates of the resident radiologists were evaluated using expert diagnoses. Then, the plaque detection rate of the resident radiologists was investigated for different plaque characteristics. The causes of incorrect stenosis diagnoses were analyzed.Results: In the investigation of carotid plaque detection, a total of 274 carotid scans from 137 patients were evaluated in our hospital. The overall agreement rate of plaque detection was 90.9%. Echolucent plaques, plaques in the lateral or near wall, and plaques in the carotid bulbs were more likely to be misdiagnosed by resident radiologists. A total of 325 plaques were included in the investigation of carotid artery stenosis classification. The overall agreement rate of stenosis evaluation was 67.7%. The misclassification of moderate stenosis was greater than that of mild and severe stenosis (p=0.0003). The sensitivity was as low as 55.56%. Nonstandard sonographic techniques and incorrect application of interpretive criteria were two main causes.Conclusions: Resident radiologists could accurately and efficiently detect carotid plaques. Scanning by resident radiologists can expand access to ultrasound services. Only the diagnosis of moderate stenosis by resident radiologists was not satisfactory and may require a specialized review from experienced radiologists.
APAQ at Forty: Publication Trends
Authors: Martin Jeffrey J. 
Published: September 2024

The purpose of the present study was to analyze Adapted Physical Activity Quarterly (APAQ) publications over the journal’s fourth decade (2014–2023) and compare them with previous documentary analyses of the first 3 decades. Consistent with prior documentary analyses, publications were coded and analyzed based on the use of theory, research participants, topic, whether the study was an intervention, first-author country affiliation, and research method. The total number of published research papers increased substantially (n = 61) from the third to the fourth decade. Similar to prior documentary analyses, most of the research was quantitative (n = 140; 57.5%), followed by qualitative research (n = 96; 39.5%). There were far more qualitative-research publications in the fourth decade compared with the third decade (n = 34). This may reflect the continued acceptance and growth of qualitative research compared with 10–20 years ago. It may also reflect the value of rich in-depth exploratory research using small samples. Additional trends included more review papers and meta-analyses, possibly reflecting the increased knowledge base in particular areas requiring synthesis. The diversity of topics also increased, with papers on dignity, classification, coaching, and the Paralympics playing more prominent roles. The number of international publications also grew substantially. In brief, the current paper outlines both similarities and differences in APAQ’s published research over the 4 decades of its existence.
The Effect of Water Dousing on Heat Strain and Performance During Endurance Running in the Heat
Authors: Anderson Mitchell , Bellenger Clint , Chaseling Georgia K. , Chalmers Samuel 
Published: September 2024

Objectives: Assess the effect of water dousing on heat strain and performance during self- and fixed-paced exercise in the heat. Design: Crossover, block-randomized controlled trial. Methods: Thirteen trained runners completed a 10-km time trial (TT) and 60-minute fixed-pace run (60% velocity of ) in a 30.4 °C, 47.4% relative humidity environment using either water dousing (DOUSE) or no dousing (CON). Results: Ten-kilometer TT performance was faster in DOUSE compared to CON (44:11 [40:48, 47:34] vs 44:38 [41:21, 47:56] min:s; P = .033). Change in core temperature (Tc) was not different between groups during the TT (+0.02 [−0.04, 0.07] °C in DOUSE; P = .853) or fixed-pace run (+0.02 [−0.15, 0.18] °C; P = .848). Change in mean skin temperature was lower in DOUSE during the TT (−1.80 [−2.15, −1.46] °C; P < .001) and fixed-pace run (−1.38 [−1.81, −0.96] °C; P < .001). Heart rate was lower for DOUSE during the fixed-pace run (−3.5 [−6.8, −0.2] beats/min; P = .041) but not during the TT (−0.2 [−2.5, 2.1] beats/min; P = .853). Thermal sensation was lower for DOUSE during the TT (−49.3 [−72.1, −26.1] mm; P < .001) and fixed-pace run (−44.7 [−59.7, −29.6] mm; P < .001). Rating of perceived exertion was not different between groups for the TT (−0.2 [−0.7, 0.3]; P = .390) or fixed-pace run (−0.2 [−0.8, 0.4]; P = .480). Sweat rate was lower for DOUSE for the TT (−0.37 [−0.53, −0.22] L/h; P < .001) and fixed-pace run (−0.37 [−0.48, −0.26] L/h; P < .001). Conclusion: Water dousing improves 10-km TT performance in the heat but does not affect Tc. The positive change in thermal perception (via lower skin temperature) during the TT likely drives this benefit.
A
Vibrio cholerae
Type IV restriction system targets glucosylated 5-hydroxymethylcytosine to protect against phage infection
Authors: Gomez Jasper B. , Waters Christopher M. 
Published: September 2024

ABSTRACT

A major challenge faced by
Vibrio cholerae
is constant predation by bacteriophage (phage) in aquatic reservoirs and during infection of human hosts. To overcome phage predation,
V. cholerae
has acquired and/or evolved a myriad of phage defense systems. Although several novel defense systems have been discovered, we hypothesized that more were encoded in
V. cholerae
given the low diversity of phages that have been isolated, which infect this species. Using a
V. cholerae
genomic library, we identified a Type IV restriction system consisting of two genes within a 16-kB region of the
Vibrio
pathogenicity island-2, which we name TgvA and TgvB (

T

ype I-embedded

g

mrSD
-like system of

V

PI-2). We show that both TgvA and TgvB are required for defense against T2, T4, and T6 by targeting glucosylated 5-hydroxymethylcytosine (5hmC). T2 or T4 phages that lose the glucose modifications are resistant to TgvAB defense but exhibit a significant evolutionary tradeoff, becoming susceptible to other Type IV restriction systems that target unglucosylated 5hmC. We also show that the Type I restriction–modification system that embeds the
tgvAB
genes protects against phage T3, secΦ18, secΦ27, and λ, suggesting that this region is a phage defense island. Our study uncovers a novel Type IV restriction system in
V. cholerae
, increasing our understanding of the evolution and ecology of
V. cholerae,
while highlighting the evolutionary interplay between restriction systems and phage genome modification.

IMPORTANCE

Bacteria are constantly being predated by bacteriophage (phage). To counteract this predation, bacteria have evolved a myriad of defense systems. Some of these systems specifically digest infecting phage by recognizing unique base modifications present on the phage DNA. In this study, we discover a Type IV restriction system encoded in
V. cholerae,
which we name TgvAB, and demonstrate it recognizes and restricts phage that have 5-hydroxymethylcytosine glucosylated DNA. Moreover, the evolution of resistance to TgvAB render phage susceptible to other Type IV restriction systems, demonstrating a significant evolutionary tradeoff. These results enhance our understanding of the evolution of
V. cholerae
and more broadly how bacteria evade phage predation.
Improving viral annotation with artificial intelligence
Authors: Flamholz Zachary N. , Li Charlotte , Kelly Libusha 
Published: September 2024

ABSTRACT

Viruses of bacteria, “phages,” are fundamental, poorly understood components of microbial community structure and function. Additionally, their dependence on hosts for replication positions phages as unique sensors of ecosystem features and environmental pressures. High-throughput sequencing approaches have begun to give us access to the diversity and range of phage populations in complex microbial community samples, and metagenomics is currently the primary tool with which we study phage populations. The study of phages by metagenomic sequencing, however, is fundamentally limited by viral diversity, which results in the vast majority of viral genomes and metagenome-annotated genomes lacking annotation. To harness bacteriophages for applications in human and environmental health and disease, we need new methods to organize and annotate viral sequence diversity. We recently demonstrated that methods that leverage self-supervised representation learning can supplement statistical sequence representations for remote viral protein homology detection in the ocean virome and propose that consideration of the functional content of viral sequences allows for the identification of similarity in otherwise sequence-diverse viruses and viral-like elements for biological discovery. In this review, we describe the potential and pitfalls of large language models for viral annotation. We describe the need for new approaches to annotate viral sequences in metagenomes, the fundamentals of what protein language models are and how one can use them for sequence annotation, the strengths and weaknesses of these models, and future directions toward developing better models for viral annotation more broadly.
Clues on the Australasian impact crater site inferred from detailed mineralogical study of a monazite inclusion in a Muong Nong tektite
Authors: Seydoux-Guillaume A.-M. , Rochette P. , Gardés E. , Zanetta P.-M. , Sao-Joao S. , de Parseval Ph. , Glass B.P. 
Published: September 2024

Abstract
Tektites are terrestrial impact-generated glasses distributed over regions of Earth's surface with ejection distances up to 10,000 km. The Australasian tektite strewn field is the largest and the youngest discovered so far (788 ka). However, the location of the source crater remains unsolved. The present work is the first to investigate the only monazite ever found as an inclusion in a Muong Nong tektite (MNT) from Indochina. In-depth observations down to the nanoscale revealed that the monazite experienced very high temperature, with silicate melt injection sometimes trapped within porosity at the grain boundaries, followed by a recovery mechanism responsible for dislocation migration and subgrain formation. The absence of radiation damage confirms that this recovery episode occurred recently, in line with the age of the tektite. The preservation of a primary zonation (Th component) and the absence of detectable diffusion profiles indicate that the monazite did not reach the melting point (∼2050 °C) before initial rapid cooling (∼1000 °C/s). The U-Th–total Pb dates of the monazite thus remained unchanged during the impact: 73 ± 6 Ma in a Th-rich domain and 156 ± 15 Ma in a Th-poor domain. This allows the source of the MNT to be constrained. Comparison with a detailed database of monazite ages and Th/U ratios in SE Asia indicates that the Australasian crater should be sought for in the triangle made up of the Philippines, coastal south China, and northern Vietnam, though the latter appears less probable.
Home-based EXercise and motivAtional programme before and after Liver Transplantation (EXALT): study protocol for phase II two-centre, randomised controlled trial
Authors:   EXALT Trial Team
Published: September 2024

IntroductionPhysical frailty is associated with increased mortality and poor quality of life (QoL) before and after liver transplantation (LT). Evidence is lacking on how to tailor exercise and behavioural techniques in this patient population.Methods and analysisHome-based EXercise and motivAtional programme before and after Liver Transplantation (EXALT) is a phase 2b, open-label, two-centre randomised controlled clinical trial designed to investigate whether a remotely monitored ‘home-based exercise and theory-based motivation support programme (HBEP)’ before and after LT improves QoL in LT recipients. Adult patients awaiting a primary LT will be assessed for eligibility at two LT centres (Birmingham, Royal Free London). Participants will be randomly assigned (1:1) to receive either an HBEP while on the LT waiting list through to 24 weeks after LT (Intervention) or a patient exercise advice leaflet (Control). Using a standard method of difference in means (two-sided significance level 0.05; power 0.90) and accounting for a 35% attrition/withdrawal rate, a minimum of 133 patients will be randomised to each treatment group. The primary outcome measure will be assessed using intention-to-treat analysis of the difference in the Physical Component Score of Short form-36 version 2.0 health-related QoL questionnaire between the groups at 24 weeks post-LT.Ethics and disseminationThe protocol was approved by the South Central-Hampshire A National Research Ethics Committee. Recruitment into the EXALT trial started in May 2022 and is due to end in June 2024, with 217/266 patients randomised to date. The intervention follow-up is due to finish in May 2026. The findings of this trial will be disseminated through peer-reviewed publications, conferences and social media.Trial registration numberISRCTN13476586.
Caesarean sections, indications and outcomes: a cross-sectional study using the Robson classification in a tertiary hospital in Sierra Leone
Authors: Arata Matteo , Boyle Sonia , Sgorbissa Beatrice , Tognon Francesca , John-Cole Valerie , Orsi Michele , Caracciolo Claudia , Saccardi Carlo , Manenti Fabio , Putoto Giovanni , K Kamara Abibatu , Betran Ana Pilar 
Published: September 2024

ObjectiveWHO recommends the use of the Robson’s ‘Ten Groups Classification’ for monitoring and assessing caesarean section (CS) rates. The aim of this study was to investigate the rates, indications and outcomes of CS using Robson classification in a tertiary hospital in Sierra Leone.DesignCross-sectional study.SettingPrincess Christian Maternity Hospital (PCMH), Freetown, Sierra Leone.ParticipantsAll women who gave birth in PCMH from 1 October 2020 to 31 January 2021.Primary and secondary outcome measuresPrimary outcome: CS rate by Robson group. Secondary outcomes: indications for CS and the newborn outcomes for each Robson group.Results1998 women gave birth during the study period and 992 CS were performed, with a CS rate of 49.6%. Perinatal mortality was 7.8% and maternal mortality accounted for 0.5%. Two-thirds of the women entered labour spontaneously and were considered at low risk (groups 1 and 3). CS rates in these groups were very high (43% group 1 and 33% group 3) with adverse outcomes (perinatal mortality, respectively, 4.1% and 6%). Dystocia was the leading indication for CS accounting for about two-thirds of the CS in groups 1 and 3. Almost all women with a previous CS underwent CS again (95%). The group of women who give birth before term (group 10) represents 5% of the population with high CS rate (50%) mainly because of emergency conditions.ConclusionOur data reveals a notably high CS rate, particularly among low-risk groups according to the Robson classification. Interpretation must consider PCMH as a referral hospital within an extremely low-resourced healthcare system, centralising all the complicated deliveries from a vast catchment area. Further research is required to assess the impact of referred obstetrical complications on the CS rate and the feasibility of implementing measures to improve the management of women with dystocia and previous CS.