bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response of mungbean to different level of macro and micronutrient
Authors: Bithy Parvin Akter 
Published: September 2024

An experiment was carried out at the Agronomy Farm of Sher-e-Bangla Agricultural University, Dhaka during Kharif I season 2024, in order to investigate the effects of zinc and calcium on growth and yield of BARI mug 6. Three levels of zinc (0, 1.5 and 3.0 kg ha-1) and four levels of calcium (0,50,75,100 ppm) were applied for the study. BARI mug 6 was used as plant material. The experiment was set up in randomized complete block design with three replications. Almost all the parameters were significantly influenced by different levels of Zn, Ca and their combinations. Considering interaction of Zn and Ca, the highest plant height (66.29 cm), number of flowers plant-1 (29.00) and number of nodules plant-1 (29.32) were obtained from the treatment combination of Zn3Ca4 where the highest chlorophyll content (Chl-a = 1.03 μg g-1, Chl-b = 1.32 μg g-1 and total = 2.48 μg g-1) were obtained from the treatment combination of Zn3Ca3.The highest dry weight plant-1 (24.70 g), number of pods plant-1 (23.24), number of seeds pod-1 (11.86), number of fertile seeds pod-1 (10.00), pod length (cm) (7.80), weight of 1000 seed (46.49), weight of seeds plant-1 (12.69), seed yield (1257 kg ha-1), stover yield (1566 kg ha-1), biological yield (2923 kg ha-1) and harvest index (43.87%) were achieved from the treatment combination of Zn2Ca3.
Res. Agric. Livest. Fish. Vol. 11, No. 2, August 2024: 159-171
Efficacy of Terminalia arjuna (Roxb.) bark extracts against Salmonella sp. isolated from aquaculture ponds
Authors: Islam Sohidul , Saha Kartik Chandra , Sultana Naima , Rahman Md Raimur , Raihan Johir , Farjana Kaniz , Raihan Rakiba Binta , Tabassum Tamanna , Acharjee Sourav , Shovon Shadman Shakib , Nibir Salman Shahriar , Kubra Khadiza Tul , Rahman Tanvir 
Published: September 2024

The present study was conducted to determine the efficacy of Terminalia arjuna bark extracts against Salmonella sp. isolated from 15 aquaculture ponds located adjacent to Bangladesh Agricultural University, Mymensingh. T. arjuna barks was dried, powdered and extracted using cold water (polar) and hexane (non-polar) and stored at 10ºC while Salmonella sp. were isolated using SS (Salmonella Shigella) Agar and selected 2 isolates were confirmed by Hi Assorted biochemical test kit. Antimicrobial activities of the bark extract of T. arjuna against fifteen selected isolates of Salmonella were then determined. Two of those selected isolates (Sa-2 and Sa-5) shown zone of inhibition against crude bark extract (hexane extract) of T. arjuna. The isolates were also screened for antibiotic resistance to eleven antibiotics. Salmonella isolates were serotyped and the antimicrobial resistance was determined by a disk diffusion method. About 100% of the isolates were resistant to antibiotic discs among which ampicillin (10 μg), and chloramphenicol (30 μg) showed 15%, azithromycin (10 μg) showed 45%, erythromycin (15 μg) showed 60%, tetracycline (10 μg) showed 40%, ampicillin (10 μg) showed 100%, doxycycline (30 μg) showed 46.67%, kanamycin (30 μg) and gentamycin (10 μg) showed 6%, streptomycin (25 μg) and ciprofloxacin (10 μg) showed 20%, and cefotaxime (30 μg) showed 30% resistant to isolated Salmonella sp. and all Salmonella sp. isolates were found to be 100% resistant to cold water extract but sensitive to hexane extract of T. arjuna. The study showed hexane extract of T. arjuna would be potential, ecofriendly and biodegradable herbal medicine to control multi drug resistant Salmonella sp. as well as aquaculture health management.
Res. Agric. Livest. Fish. Vol. 11, No. 2, August 2024: 255-269
Penyuluhan penyakit IMS pada Karyawan Karaoke di Tempat Karaoke Kota Langgur dan Kabupaten Maluku Tenggara
Authors: Manuputty Amanda Gracia , Saija Alessandra , Huwae Laura Bianca Sylvia , Istia Sean , Kadarsih Bandjar Fitri , Evan Wijaya Aldo , Alaudilah Harahap Iqbal , Najira Kabakoran Dewi 
Published: September 2024

Infeksi Menular Seksual (IMS) memiliki pengaruh yang signifikan terhadap kesehatan seksual dan reproduksi dalam skala global. Kejadian IMS melebihi 1 juta kasus setiap harinya yang menyoroti dampak luas dari infeksi ini. Dampak IMS dapat melampaui dampak langsung dari infeksi itu sendiri yang dapat menyebabkan konsekuensi serius. Angka kesakitan dan kematian akibat Infeksi Menular Seksual (IMS) sangat tinggi di kawasan Asia Tenggara. Oleh karena itu, perlu adanya peningkatan kesadaran mengenai kesehatan seksual dan reproduksi ibu, bayi baru lahir, dan anak. Menyoroti situasi saat ini, perlu dilakukan langkah-langkah segera untuk memposisikan pengendalian IMS sebagai prioritas kesehatan masyarakat. Metode pengabdian masyarakat terdiri dari pre-test, edukasi, dan post-test. Pengabdian masyarakat yang dilakukan di tempat karaoke Kota Langgur, Kabupaten Maluku Tenggara memberikan dampak positif dengan adanya peningkatan pengetahuan pada peserta yang mengikuti kegiatan mengenai infeksi menular seksual. Secara keseluruhan pengetahuan mengenai infeksi menular seksual dan HIV/AIDS pada karyawan karaoke sudah cukup baik, terlihat dari peningkatan hasil post-test. Selain itu, peserta yang positif terinfeksi penyakit menular seksual diharapkan dapat diobati sesuai standar operasional yang berlaku.
Kemampuan literasi matematis dan keterampilan sosial melalui model project based learning
Authors: Maysarah Siti , Saragih Sahat , Armanto Dian , Siregar Hasratuddin 
Published: September 2024

Kemampuan literasi matematis merupakan kemampuan matematis yang sangat penting untuk dikuasai oleh siswa. Literasi matematis dapat diartikan sebagai pengetahuan untuk mengetahui dan menerapkan matematika dasar dalam kehidupan sehari-hari. Literasi matematis meliputi kemampuan seseorang untuk merumuskan, menerapkan, dan menafsirkan matematika dalam berbagai konteks, termasuk kemampuan melakukan penalaran secara matematis dan menggunakan konsep, prosedur, dan fakta untuk menggambarkan, menjelaskan, atau memperkirakan fenomena atau kejadian. Selain itu, keterampilan sosial juga merupakan hal yang penting dikuasai oleh siswa dalam pembelajaran matematika. Dengan adanya keterampilan sosial, siswa dapat dengan mudah berinteraksi dengan orang lain. Sehingga diharapkan dapat dengan mudah dalam menyelesaikan permasalahan matematika. Salah satu model pembelajaran yang dapat meningkatkan keterampilan sosial adalah model project based learning. Model ini memudahkan siswa untuk saling berinteraksi dalam pengerjaan proyek. Penelitian ini bertujuan untuk melihat bagaimana kemampuan literasi matematis dan keterampilan sosial melalui model project based learning. Jenis penelitian ini adalah kualitatif dengan metode penelitian studi pustaka (library research). Teknik pengumpulan data dilakukan dengan cara mencari sumber seperti buku, jurnal, dan hasil-hasil penelitian yang telah ada. Hasil dalam penelitian ini adalah model project based learning dapat meningkatkan kemampuan literasi matematis dan keterampilan sosial siswa.
Analisis keterampilan metakognisi mahasiswa dalam menyelesaikan soal persamaan diferensial
Authors: Tonra Winda Syam , Wahyudi Dahlan , Tonra Wilda Syam 
Published: September 2024

Penelitian ini merupakan penelitian deskriptif kualitatif bertujuan untuk menganalisis keterampilan metakognisi dalam menyelesaikan soal persamaan diferensial. Keterampilan metakognisi mahasiswa dalam penelitian ini adalah kegiatan yang dilakukan seseorang yang berkaitan dengan kesadaran dan pengaturan kognisinya dalam memecahkan masalah meliputi perencanaan, monitoring, dan evaluasi. Subjek penelitian ada 2 mahasiswa yakni 1 mahasiswa kemampuan dasar matematika tinggi (MT) dan 1 mahasiswa kemampuan dasar matematika sedang (MS). Instrument penelitian ini adalah instrument utama (peneliti sendiri) dan instrumen bantu yaitu soal tes tentang persamaan diferensial serta pedoman wawancara. Proses pengumpulan data dilakukan dengan cara memberikan soal persamaan diferensial kepada kedua subjek dan melakukan wawancara pada saat subjek mengejakan soal. Proses analisis data yakni reduksi data, penyajian data, serta penarikan kesimpulan. Hasil penelitian menunjukkan bahwa MT melibatkan semua indikator keterampilan metakognisi dalam menyelesaikan soal persamaan diferensial yaitu indikator perencanaan, monitoring dan evaluasi. Sedangkan MS hanya melibatkan satu indikator keterampilan metakognisi dalam menyelesaiakan soal persamaan diferensial yaitu indikator perencanaan. Kesimpulannya dalam menyelesaikan masalah persamaan diferensial Subjek MT melibatkan keseluruhan indikator keterampilan metakognisi sedangkan MS hanya satu indikator keterampilan metakognisi. Kata kunci : Persamaan diferensial, keterampilan metakognisi
The development of the Questionnaire of (Central) Auditory Processing: a screening tool of auditory processing
Authors: Tabone Nadine , Grech Helen , Bamiou Doris-Eva 
Published: September 2024

ObjectiveThe aim of this study was to develop a screening questionnaire for auditory processing disorder (APD) targeted for the Maltese pediatric population.MethodThe questionnaire consisted of 25 close-ended questions in which parents rated their child's listening skills. The data was collected from 101 typically developing Maltese bilingual children and 30 children forming a clinical group, aged between 7;00 and 9;11 years.ResultsThe tool was found to be highly reliable with an internal consistency of 0.92 and test-retest reliability of 0.94. Significant differences emerged between normal and clinical groups (p = &lt; 0.001). Correlational analysis demonstrated a significant correlation between the Questionnaire of (Central) Auditory Processing (QCAP) and the speech-in-noise test, Duration Patterns Test and tests of dichotic listening.ConclusionThe QCAP is potentially an effective screening tool for highlighting listening difficulties in Maltese children at risk of having APD.
Head-to-head comparison of two human papillomavirus vaccines for efficacy against cervical intraepithelial neoplasia grade 3 and adenocarcinoma in situ—population-based follow-up of two cluster-randomized trials
Authors: Lehtinen Matti , Gray Penelope , Luostarinen Tapio , Eriksson Tiina , Apter Dan , Bly Anne , Harjula Katja , Heikkilä Kaisa , Hokkanen Mari , Kuortti Marjo , Nieminen Pekka , Nummela Mervi , Paavonen Jorma , Palmroth Johanna , Petäjä Tiina , Pimenoff Ville N. , Pukkala Eero , Dillner Joakim 
Published: September 2024

IntroductionWe report head-to-head comparison of the bivalent and quadrivalent HPV vaccine efficacies against immediate precursors of cervical cancer from 15 years’ country-wide cancer registry follow-up of phase III trial cohorts and an age-aligned cohort of unvaccinated women.MethodsThese individually and/or clusterrandomized cohorts of HPV6/11/16/18- and HPV16/18-vaccinated and unvaccinated women were enrolled, respectively, in 2002, 2004, and 2003/2005. The trial cohorts comprised initially 16- to 17-year-old HPV6/11/16/18-vaccinated FUTURE II (NCT00092534) participants (866) and HPV16/18-vaccinated PATRICIA (NCT00122681) and 012 trial (NCT00169494) participants (2,465), and 16,526 initially 16- to 19-year-old unvaccinated controls. After active 4-year clinical follow-up, passive, country-wide Finnish Cancer Registry (FCR) follow-up for cervical intraepithelial neoplasia grade 3 (CIN3) and adenocarcinoma in situ (AIS) was based on consented use of unique personal identifiers and started 6 months after the end of the FUTURE II and PATRICIA trials in 2007 and 2009, and ended at the end of 2019. The follow-up with altogether 229,020 follow-up years was age-aligned to ensure that similarly aged cohorts were passively followed up for 15 years post=vaccination for the intention-to-treat analyses of vaccine efficacy.ResultsOverall, we identified 5 and 16 CIN3 (no AIS) cases in the HPV6/11/16/18 and HPV16/18 cohorts, respectively, during the FCR-based follow-up. In the unvaccinated cohort, we identified 281 CIN3 cases, 20 AIS cases, and 13 cases with invasive cervical cancer. Vaccine efficacies against CIN3+ were 68.4% and 64.5% for the quadrivalent and the bivalent vaccines, respectively, with overlapping confidence intervals.DiscussionLong-term follow-up of randomized, initially adolescent HPV-vaccinated and unvaccinated cohorts shows, in this head-to-head setting, that the bivalent and quadrivalent HPV vaccines are equally effective against immediate precursors of cervical cancer.
Endoluminal rescue of false lumen graft deployment in TEVAR for type B aortic dissection: a case report and literature review
Authors: Zhu Hong Jiang , Yan Feng , Zhao Peng Peng 
Published: September 2024

BackgroundThoracic endovascular aortic repair (TEVAR) has increasingly become the preferred surgical intervention for Stanford type B aortic dissection (TBAD). The primary objective of this procedure is to seal the primary entry tear to promote positive aortic remodeling. However, the increased use of TEVAR has also led to a rise in surgical complications. Among these, the accidental deployment of the stent into the false lumen is a rare but serious complication that can result in aortic false lumen rupture and inadequate perfusion of abdominal organs.Case summaryThis case report described a 78-year-old man who presented to our hospital with sudden onset chest and back pain and was subsequently diagnosed with TBAD via aortic CTA. As conventional medical therapy failed to alleviate his chest pain, the patient underwent TEVAR. During the procedure, a complication arose when the distal end of the endograft was mistakenly deployed into the false lumen, leading to insufficient perfusion of the abdominal organs. Recognizing this issue intraoperatively, an additional endograft was promptly inserted at the distal end to reroute blood flow back to the true lumen of the aorta, thereby restoring visceral perfusion. Post-intervention, the patient's chest pain improved, and he was successfully discharged from the hospital.ConclusionAccidental deployment of a endograft into the false lumen during TEVAR is a rare but serious complication. Intraoperative angiography plays a crucial role in rapidly and accurately identifying this issue by detecting insufficient perfusion of abdominal organs. The use of intravascular ultrasound may help reduce the incidence of this complication. Endovascular repair is an effective emergency strategy to quickly redirect blood flow back to the true lumen, making it the preferred method for managing such emergencies.
Enhancing engineering students’ satisfaction with online learning: factors, framework, and strategies
Authors: Al-Khatib Maryam , Alkhatib Amira , Talhami Mohammed , Kashem Abdurahman Hafez Mohammed , Ayari Mohamed Arselene , Choe Pilsung 
Published: September 2024

IntroductionThe learning experience has undergone significant changes recently, particularly with the adoption of advanced technology and online lectures to address challenges such as pandemics. In fields like engineering, where hands-on classes are essential, the online learning environment plays a crucial role in shaping students’ experiences and satisfaction.MethodsThis study aimed to explore the key factors affecting engineering students’ satisfaction with online learning. A structured survey was administered to 263 students across various engineering disciplines and academic levels, all of whom had experienced both in-person learning before the pandemic and online learning during the pandemic. Factor analysis and multiple linear regression were employed to analyze the data.ResultsThe analysis identified interactions, services, and technology as the main factors positively influencing online learning satisfaction. The regression analysis further revealed that students’ satisfaction is significantly dependent on the availability and quality of online learning services, assessment and interaction tools, and technology.DiscussionThis study highlights the critical factors that enhance engineering students’ satisfaction with online learning. It offers strategies for educators to improve online learning environments, emphasizing the importance of quality services, assessment, and interaction tools. These findings can guide the development of more effective online learning experiences in engineering education.
The association between the weight-adjusted-waist index and frailty in US older adults: a cross-sectional study of NHANES 2007–2018
Authors: Jia Shanshan , Huo Xingwei , Sun Lirong , Yao Yuanyuan , Chen Xiaoping 
Published: September 2024

ObjectiveThis study aimed to evaluate the relationship between the weight-adjusted waist circumference index (WWI) and the frailty in American adults aged over 60 years.MethodsWe utilized data from the National Health and Nutrition Examination Surveys (NHANES) spanning from 2007 to 2018. WWI was calculated using the square root of waist circumference (cm) divided by body weight (kg). The frailty index ≥ 0.25 was employed to assess frailty. Weighted multivariate logistic regression was conducted to explore the association between WWI and frailty. Generalized Additive Modeling (GAM) was used to explore potential non-linear relationships. Receiver operating characteristic curve (ROC) analysis was used to assess the predictive ability of WWI for frailty.ResultsThe study encompassed 7765 participants. Higher WWI was significantly associated with higher odds of frailty. In the fully adjusted model, each unit increase of WWI was associated with an 82% increased odds of frailty (OR: 1.82, 95% CI: 1.61 – 2.06; P &lt; 0.001). GAM found significant nonlinear relationships and threshold effects.ConclusionThe study presented a robust correlation between elevated WWI and increased odds of frailty among American older adults. However, these findings require further validation in large-scale, prospective studies.
From proteome to pathogenesis: investigating polycystic ovary syndrome with Mendelian randomization analysis
Authors: Zhang Jiaqi , Li Yuqing , Gong Aixia , Wang Jingmin 
Published: September 2024

BackgroundPolycystic ovary syndrome (PCOS) is defined by oligo/anovulation, hyperandrogenism, and polycystic ovaries with uncertain pathogenesis. The proteome represents a substantial source of therapeutic targets, and their coding genes may elucidate the mechanisms underlying PCOS. However, reports on the profiles of the human plasma protein-coding genes and PCOS are limited. Here, we aimed to investigate novel biomarkers or drug targets for PCOS by integrating genetics and the human plasma proteome.MethodsOur study acquired the protein quantitative trait loci from DECODE Genetics, offering 4,907 proteins in 35,559 individuals while obtaining PCOS summary statistics by accessing the FinnGen biobank (1,639 cases and 218,970 controls) and the genome-wide association study catalog (797 cases and 140,558 controls). Herein, we sequentially used two-sample Mendelian randomization (MR) analyses and colocalization to verify the causal link between candidate proteins, their coding genes, and PCOS. Further PCOS data download was conducted by accessing the Gene Expression Omnibus and Zenodo platforms. Gene expression level analysis, pathway enrichment analysis, immune cell infiltration, and transcription factor prediction were performed, aiming at detecting specific cell types with enriched expression and exploring potential optimized treatments for PCOS.ResultsMR analysis revealed 243 protein-coding genes with a causal relationship to PCOS risk, of which 12 were prioritized with the most significant evidence. Through colocalization analysis, three key genes, CUB domain-containing protein 1 (CDCP1), glutaredoxin 2 (GLRX2), and kirre-like nephrin family adhesion molecule 2 (KIRREL2), were identified. Subsequently, the three genes were strongly related to immune function and metabolism in terms of biological significance. In single-cell analysis, the expression levels of genes in ovarian theca cells were explored.ConclusionOverall, three protein-coding genes (CDCP1, GLRX2, and KIRREL2) may be related to a higher PCOS risk, suggesting that they may be entry points for exploration of PCOS pathogenesis and treatment, warranting further clinical investigations.
Case report: Whole exome sequencing reveals a novel splicing variant of ANKRD17 gene in a Chinese male juvenile with developmental delay and transient tic disorder
Authors: Chen Jing , Yang Shuo , Wang He , Wang Hongjing , Xiao Yuanyuan , Liu Shanling 
Published: September 2024

BackgroundThe Ankyrin Repeat Domain Containing Protein 17 (ANKRD17, OMIM:615929) gene is a protein-coding gene associated with diseases such as Chopra-Amiel-Gordon Syndrome and Non-Specific Syndromic Intellectual Disability. The protein encoded by ANKRD17 gene belongs to the ankyrin repeat-containing protein family, which is one of the most widely existing protein domains that exclusively mediate protein-protein interactions. To date, the research and reports on the ANKRD17 gene are limited.Case presentationTrio whole exome sequencing (Trio-WES) was conducted on the proband and his unaffected parents to elucidate the genetic etiology in the proband, who was clinically diagnosed with developmental delay and other phenotypes. Subsequently, Sanger sequencing was employed for validation of the identified candidate variant. Furthermore, RNA analysis was utilized to ascertain the impact of the variant on splicing. The WES revealed a novel heterozygous ANKRD17 splicing variant (c.7248 + 1G&gt;A) in the proband, but not detected in his unaffected parents. And the presence of the splicing variant of the ANKRD17 gene was valided by the Sanger sequencing subsequently. And the RNA analysis confirmed that the novel variant was predicted to result in loss of donor splice site, and the analysis at mRNA level confirmed that it leads to exon 32 skipping (r.7100_7278del179) and causes premature termination of translation to the protein (p.D2357fs), therefore is classified as pathogenic.ConclusionOur study reported a novel splicing variant in ANKRD17 gene, which may be associated with partial eating, frequent urination, and tic syndrome. This finding expands both the phenotypic and genotypic spectrum of ANKRD17 gene. Although there is currently no curative therapy available for ANKRD17 gene variants, a definitive diagnosis of its genetic etiology is significant for genetic counseling and family planning purposes. Furthermore, this is the first reported case of the ANKRD17 gene in China.