bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of 20% intravenous lipid emulsion for the treatment of loperamide toxicosis in a Collie homozygous for the ABCB1‐1∆ mutation
Authors: Long Whitney M. , Sinnott Virginia B. , Bracker Kiko , Thomas Danielle 
Published: December 2016

AbstractObjectiveTo describe the successful treatment of loperamide toxicosis in a dog using intravenous lipid emulsion (ILE).Case SummaryAn 8‐month‐old male neutered Rough Collie weighing 20.0 kg was given a total dose of 0.75 mg/kg loperamide over 3 days as treatment for diarrhea. The dog was subsequently evaluated for signs of dull mentation, anxiety, ptyalism and ataxia, thought to be a result of loperamide intoxication. The dog was treated with a 1.5 mL/kg IV bolus of 20% ILE solution followed by 0.25 mL/kg/min of the same solution for 2 hours. The dog's mentation improved rapidly following ILE infusion, and he was neurologically normal 3 hours after initiation of ILE treatment. The dog was subsequently found to be homozygous for the ATP‐binding cassette (ABC) transporter gene (ABCB1‐1∆) mutation. There were no adverse effects noted during or following ILE infusion.New or Unique Information ProvidedILE was successful in the treatment of loperamide toxicosis in a Collie with the ABCB1‐1∆ mutation. ILE may be of benefit for treatment of other intoxications in dogs with ABCB1‐1Δ mutations.
Laparoscopic kidney biopsy in dogs: Comparison of cup forceps and core needle biopsy
Authors: Park Jiyoung , Lee Jinwoo , Lee Hae‐Beom , Jeong Seong Mok 
Published: December 2016

AbstractObjectiveTo investigate the feasibility of laparoscopic kidney biopsy with cup biopsy forceps in dogs (CupBF), and to compare to the use of a core biopsy needle (CoreBN).Study DesignExperimental; randomized, controlled design.AnimalsEight healthy, adult Beagle dogs.MethodsDogs were randomized to undergo laparoscopic biopsy of the right kidney using either 5 mm CupBF or a 16 gauge CoreBN. Intraoperative hemorrhage of the biopsy site was monitored. Biopsy quality was evaluated for tissue fragmentation and crushing, presence of renal cortex with or without medulla, and number of glomeruli. Postoperative packed cell volume, urinalysis, and ultrasonographic appearance of the biopsy site were evaluated.ResultsBiopsy specimens were obtained by both techniques and reliable hemostasis was achieved with direct compression in all dogs. The histologic score for CupBF biopsies was not significantly different from CoreBN biopsies. One CoreBN biopsy contained both renal cortex and medullar, while all CupBF biopsies contained cortex only. The mean (SD) number of glomeruli was significantly higher in CupBF biopsies [60 (9.1)] than CoreBN biopsies [26 (4.3)]. There was no gross hematuria, perirenal hematoma, or hydronephrosis in any dog postoperative.ConclusionLaparoscopic kidney biopsy in dogs using 5 mm cup biopsy forceps is feasible with minimal risk and more glomeruli obtained compared to laparoscopic kidney biopsy using 16 gauge core biopsy needles.
Total laparoscopic gastropexy using 1 simple continuous barbed suture line in 63 dogs
Authors: Takacs Joel D. , Singh Ameet , Case J. Brad , Mayhew Philipp D. , Giuffrida Michelle A. , Caceres Ana V. , Fox‐Alvarez W. Alexander , Runge Jeffrey J. 
Published: December 2016

AbstractObjectiveTo describe the use and outcome of a single, simple continuous, barbed suture line for prophylactic, total laparoscopic gastropexy in dogs.Study DesignMulti‐center, retrospective case series.AnimalsSixty‐three client‐owned dogs.MethodsMedical records of dogs undergoing total laparoscopic gastropexy using a barbed suture at 4 academic veterinary hospitals from 2011‐2015 were reviewed. Data collected included signalment, procedure time, procedure‐associated complications, short‐term complications, and long‐term outcome. All procedures were performed under general anesthesia in dorsal to dorsal‐left oblique recumbency. Laparoscopic ports were placed on ventral midline in 1 of 3 port configurations, and 5 mm laparoscopic needle drivers were used for intracorporeal sutured gastropexy with unidirectional barbed suture. The gastropexy was positioned just caudal to the 13th rib, 2‐4 cm lateral to the rectus abdominis muscle.ResultsSixty‐three dogs underwent total laparoscopic gastropexy with a single, simple continuous, barbed suture line. Median gastropexy surgery time was 70 minutes (interquartile range [IQR] 60‐90 minutes). One dog sustained splenic laceration from Veress needle penetration during initial abdominal insufflation. Short term (>24 hours to 6 months postoperative) complications included incisional seroma formation (n = 2) and suture reaction (n = 1). Long term (>6 months postoperative) complications included intermittent regurgitation and chronic diarrhea in 1 dog. Fifteen dogs had postoperative ultrasound and all had intact gastropexy sites.ConclusionTotal laparoscopic barbed gastropexy using a single, simple continuous, barbed suture line in dogs is safe and results in an intact gastropexy long term.
The mitochondrial calcium uniporter in the heart: energetics and beyond
Authors: Kwong Jennifer Q. 
Published: December 2016

AbstractCa2+ and mitochondria are inextricably linked to cardiac function and dysfunction. Ca2+ is central to cardiac excitation–contraction coupling and stimulates mitochondrial energy production to fuel contraction. Under pathological conditions of dysregulated Ca2+ cycling, mitochondrial Ca2+ overload activates cellular death pathways. Thus, in the cardiomyocyte, the mitochondrial Ca2+ microdomain is where contraction, energy and death collide. A key component of mitochondrial Ca2+ signalling is the mitochondrial Ca2+ uniporter complex (uniplex), an inner membrane Ca2+ transporter and major pathway of mitochondrial Ca2+ entry. Once known only as the unidentified target for ruthenium red and related compounds, in recent years, the uniplex has evolved into a complex multiprotein assembly. The identification of the molecular constituents of the uniplex has made possible the generation of targeted genetic models to interrogate uniplex function in vivo. This review will summarize our current understanding of the molecular structure of the uniplex, its impact on mitochondrial energetics and cardiac physiology, its contribution to cardiomyocyte death, and its expanding roles in cardiac biology.
image
Experimental and Numerical Investigations on Louvered Fin-and-Tube Heat Exchanger With Variable Geometrical Parameters
Authors: Javaherdeh Kourosh , Vaisi Ahmad , Moosavi Rouhollah , Esmaeilpour Mehdi 
Published: December 2016

The effects of geometrical arrangement on the heat transfer and pressure drop characteristics in compact louvered fin-and-tube heat exchangers were studied experimentally and numerically along with ε−NTU method. Different geometrical parameters including louver angle, louver pitch, louver number, the nonlouvered inlet and exit fin length, and redirection of fluid flow are considered to determine their effects on the flow field. The study is performed for different louver angles varying from θL=12 to 60 deg, and optimal heat transfer rate is obtained at louver angle of θL=28deg. Also, it is found that increasing the louver number, NL, on the fin surface enhances the heat transfer performance. It is shown that the average Nusselt number is increased as the louver pitch is decreased and its optimum value is obtained at Lp=0.9 mm. However, comparing to the effect of louver number, the louver pitch has a small effect on the performance of the heat exchanger. Additionally, the optimum values of nonlouvered inlet and exit fin length and redirection length of fin are obtained with different flow conditions.
A Comparative Study of the Effects of Pilates and Latin Dance on Static and Dynamic Balance in Older Adults
Authors: Sofianidis George , Dimitriou Anna-Maria , Hatzitaki Vassilia 
Published: December 2016

The present study was designed to compare the effectiveness of exercise programs with Pilates and Latin dance on older adults’ static and dynamic balance. Thirty-two older adults were divided into three groups: Pilates group, Dance group, and Control group. Static and dynamic balance was assessed with following tasks: (a) tandem stance, (b) one-leg stance, and (c) periodic sway with and without metronome guidance. Analysis revealed a significant reduction of the trunk sway amplitude during the tandem stance with eyes closed, reduction in the center of pressure (CoP) displacement during one-leg stance, and increase in the amplitude of trunk oscillation during the sway task for both intervention groups, and reduction in the standard deviation of the CoP displacement during the metronome paced task only for the dance group. The differences in specific balance indices between the two programs suggest some specific adaptations that may provide useful knowledge for the selection of exercises that are better tailored to the needs of the old adult
Analysis of Gauntlet Test Performance and Injury Risk in Intercollegiate Division I Female Soccer (Football) Players: A Retrospective Study
Authors: Ness Brandon M. , Zimney Kory , Schweinle William E. 
Published: December 2016

Context:Injury risk factors and relevant assessments have been identified in women’s soccer athletes. Other tests assess fitness (eg, the Gauntlet Test [GT]). However, little empirical support exists for the utility of the GT to predict time loss injury.Objectives:To examine the GT as a predictor of injury in intercollegiate Division I female soccer athletes.Design:Retrospective, nonexperimental descriptive cohort study.Setting:College athletic facilities.Participants:71 female Division I soccer athletes (age 19.6 ± 1.24 y, BMI 23.0 ± 2.19).Main Outcome Measures:GT, demographic, and injury data were collected over 3 consecutive seasons. GT trials were administered by coaching staff each preseason. Participation in team-based activities (practices, matches) was restricted until a successful GT trial. Soccer-related injuries that resulted in time loss from participation were recorded.Results:71 subjects met the inclusion criteria, with 12 lower body time loss injuries sustained. Logistic regression models indicated that with each unsuccessful GT attempt, the odds of sustaining an injury increased by a factor of 3.5 (P < .02). The Youden index was 2 GT trials for success, at which sensitivity = .92 and specificity = .46. For successive GT trials before success (1, 2, or 3), the predicted probabilities for injury were .063, .194, and .463, respectively.Conclusions:The GT appears to be a convenient and predictive screen for potential lowerbody injuries among female soccer athletes in this cohort. Further investigation into the appropriate application of the GT for injury prediction is warranted given the scope of this study.
The Role of Gender in Neuropsychological Assessment in Healthy Adolescents
Authors: Mormile Megan Elizabeth Evelyn , Langdon Jody L. , Hunt Tamerah Nicole 
Published: December 2016

Context: Research in college athletes has revealed significant gender differences in areas of verbal memory, visual memory, and reaction time. Additionally, research has focused on differences in neuropsychological components and gender in college populations; however, such differences in gender have not been documented in healthy adolescent populations. Purpose: To identify potential differences between males and females using different components of a common computerized neuropsychological test. Methods: A computerized neuropsychological test battery (ImPACT®) was administered to 662 high-school age adolescent athletes (male: n = 451 female: n = 262). Differences between genders were calculated using a 1-way ANOVA. All statistical analyses were conducted using SPSS 23.0. Significance levels were set a priori at P < .05. Results: A 1-way ANOVA revealed statistically significant differences between males and females for composite reaction time (F1,660 = 10.68, P = .001) and total symptom score (F1,660 = 81.20, P < .001). However, no statistically significant differences were found between males and females in composite verbal memory, visual memory, visual motor, or impulse control (P > .05). Conclusions: Significant differences between males and females were discovered for composite reaction time and total symptom scores, with females reporting more symptoms and slower reaction times at a baseline assessment. Increased symptom reporting by females may be attributed to both hormonal differences and increased honesty. Quicker reaction times in males may support theories that repetition of activities and quicker muscle contraction are gender dependent. However, additional research is necessary to understand gender differences in adolescent athletes during periods of cognitive and physical maturation.
Clinical and pH study characteristics in reflux patients with and without ineffective oesophageal motility (IEM)
Authors: Triadafilopoulos George , Tandon Apurva , Shetler Katerina P , Clarke John 
Published: December 2016

BackgroundThe aetiology and clinical impact of ineffective oesophageal motility (IEM) remain poorly understood, but the condition is thought to worsen supine gastro-oesophageal acid reflux (GERD).AimsIn this retrospective cohort analysis of symptomatic patients with abnormal oesophageal acid exposure, we sought to determine any clinical or functional characteristics that would distinguish those with normal peristalsis from those with IEM, defined using the Chicago classification. We hypothesised that the impaired oesophageal clearance in IEM would be contributing to more severe degrees of pathological acid exposure, as well as clinical and endoscopic GERD severity.MethodsConsecutive symptomatic patients with GERD underwent clinical, endoscopic and functional evaluation that included high-resolution impedance manometry (HRIM) and ambulatory pH monitoring performed ‘off’ acid suppressive therapy.ResultsOf the 114 patients with abnormal oesophageal acid exposure, 71 had normal oesophageal motility by HRIM and 43 were diagnosed with IEM (38% prevalence). Age, gender and symptom duration were similar between the two groups. Both groups had similar magnitude and frequency of symptoms, making a distinction clinically impossible. Endoscopically, the two groups had similar rates of erosive disease, hiatal hernia and Barrett's oesophagus. Ambulatory pH, proton pump inhibitor (PPI) dosage and PPI response rates were also similar. Nevertheless, patients with IEM had significantly more impairment of oesophageal clearance (mean 56.9±6.4) than those with normal motility (mean 32.4±5.0) (p<0.003).ConclusionsSymptomatic patients with IEM exhibit significant impairment of oesophageal clearance but are otherwise clinically indistinguishable from those with normal oesophageal motility and have a similar prevalence of erosive disease and pathological acid exposure.
Diagnose emendada de Gangamopteris buriadica Feistmantel do Permiano do Gondwana
Authors: Iannuzzi Roberto , Bernardes-de-Oliveira Mary Elizabeth Cerruti , Pillai Sankar Suresh Kumar , Tybusch Graciela Pereira , Hoelzel Amanda 
Published: December 2016

O principal objetivo deste estudo é reavaliar os caracteres diagnósticos de Gangamopteris (?) buriadica Feistmantel com base na análise do material tipo, depositado na coleção do Serviço Geológico da Índia, Calcutá, e outros espécimes depositados em distintas coleções situadas no sudeste (São Paulo, Rio de Janeiro) e sul (Porto Alegre) do Brasil. Um recente reexame do material tipo revelou uma feição tafonômica única: a lâmina foliar está lateralmente dobrada sobre si mesma. Este fato implica em uma nova interpretação da forma da folha de um contorno lanceolado-espatulado para um mais ovalado-obovado. Além disso, a visão apenas parcial da lâmina não permite o entendimento do verdadeiro padrão das veias laterais por completo, as quais se inclinam em direção às margens laterais. Como uma conseqüência desta reinterpretação, propomos uma emenda à diagnose original desta espécie, a fim de incluir a lâmina curvada e o padrão de venação das margens laterais da folha como características diagnósticas da mesma. Alguns outros espécimes dos estratos permianos iniciais da Bacia do Paraná, também demonstraram essas mesmas feições diagnósticas e por isso foram incluídas nesta espécie fóssil. Conseqüentemente, a ocorrência de G. buriadica Feistm. emend. é confirmada e estendida para a Bacia do Paraná, sendo estratigráfica (Grupo Itararé e Formação Rio Bonito) e geograficamente (estados de São Paulo e Rio Grande do Sul) distribuída pelo sudeste-sul do Brasil. Por último, os significados taxonômico, tafonômico e ecológico da presença de folhas curvadas são brevemente discutidos.
ANALYSE SEMANTIQUE DE LA LOCALISATION EN CHINOIS
Authors: Renaud Francis 
Published: December 2016

A SEMANTIC ANALYSIS OF SOME LOCATIVE CONCEPTS IN CHINESEThe representation of meaning in natural languages is quite a complex task, which can only be achieved by means of approximative model constructions within the frame of a powerful formalism. This paper provides an introduction to some basic locative concepts, in the formal apparatus of lambda-calculus.
Robust differential expression analysis by learning discriminant boundary in multi-dimensional space of statistical attributes
Authors: Bei Yuanzhe , Hong Pengyu 
Published: December 2016

Abstract
Background
Performing statistical tests is an important step in analyzing genome-wide datasets for detecting genomic features differentially expressed between conditions. Each type of statistical test has its own advantages in characterizing certain aspects of differences between population means and often assumes a relatively simple data distribution (e.g., Gaussian, Poisson, negative binomial, etc.), which may not be well met by the datasets of interest. Making insufficient distributional assumptions can lead to inferior results when dealing with complex differential expression patterns.

Results
We propose to capture differential expression information more comprehensively by integrating multiple test statistics, each of which has relatively limited capacity to summarize the observed differential expression information. This work addresses a general application scenario, in which users want to detect as many as DEFs while requiring the false discovery rate (FDR) to be lower than a cut-off. We treat each test statistic as a basic attribute, and model the detection of differentially expressed genomic features as learning a discriminant boundary in a multi-dimensional space of basic attributes. We mathematically formulated our goal as a constrained optimization problem aiming to maximize discoveries satisfying a user-defined FDR. An effective algorithm, Discriminant-Cut, has been developed to solve an instantiation of this problem. Extensive comparisons of Discriminant-Cut with 13 existing methods were carried out to demonstrate its robustness and effectiveness.

Conclusions
We have developed a novel machine learning methodology for robust differential expression analysis, which can be a new avenue to significantly advance research on large-scale differential expression analysis.
Impact of a 6-month treatment with intragastric balloon on body composition and psychopathological profile in obese individuals with metabolic syndrome
Authors: Guedes Erika P. , Madeira Eduardo , Mafort Thiago T. , Madeira Miguel , Moreira Rodrigo O. , Mendonça Laura Maria C. , Godoy-Matos Amélio F. , Lopes Agnaldo J. , Farias Maria Lucia F. 
Published: December 2016

Abstract
Background
The aim of this study was to investigate the effects of a 6-month treatment with intragastric balloon (IGB) on body composition and depressive/anxiety symptoms in obese individuals with metabolic syndrome (MS).

Methods
Fifty patients (aged 18–50 years) with obesity and MS were selected for treatment with IGB for 6 months. Body composition was verified with dual-energy X-ray absorptiometry (DXA) at baseline and right after IGB removal. Anxiety/depressive symptoms were assessed with the Beck Depression Inventory (BDI) and the hospital anxiety and depression scale (HADS) at baseline and after 6 months of treatment.

Results
In total, 39 patients completed the study. After 6 months, there were significant decreases in weight (11.7 ± 9.6 kg, p < 0.0001) and waist circumference (9.3 ± 8.2 cm, p < 0.0001). Weight loss was also demonstrated by DXA and corresponded to decreases of 3.0 ± 3.4% in body fat percentage, 7.53 ± 7.62 kg in total body fat, and 3.70 ± 4.89 kg in lean body mass (p < 0.001 for all comparisons). Depressive symptoms scores decreased by a mean of 4.57 ± 10.6 points when assessed with the BDI (p = 0.002) and 1.82 ± 5.16 points when assessed with the HADS-Depression (p = 0.0345). Anxiety symptoms scores decreased by a mean of 1.84 ± 4.04 points when determined with the HADS-anxiety (p = 0.0066). The decrease in body fat percentage was the parameter that best correlated with improvements in depressive (p = 0.008) and anxiety symptoms (p = 0.014).

Conclusions
In obese individuals with MS, fat mass reduction was associated with short-term improvements in depressive and anxiety symptoms.
Trial Registration Registered at ClinicalTrials.gov, NCT01598233
Clinical protein science developments for patient monitoring in hospital central laboratories
Authors: Malm Johan , Marko‐Varga György 
Published: December 2016

AbstractPatient care relies heavily on standardized tests performed in hospital laboratories, typically including clinical chemistry, pathology and microbiology. With the introduction of personalized medicine tremendous efforts have been made to identify new biomarkers of disease with various omics technologies, often including mass spectrometry. In order to validate new biomarkers and perform clinical studies high quality biobank samples are of key importance. In this editorial different aspects of mass spectrometry in future personalized medicine are discussed.
Protein metabolism and physical training: any need for amino acid supplementation?
Authors: Poortmans Jacques R. , Carpentier Alain 
Published: December 2016

AbstractMuscle mass is the major deposit of protein molecules with dynamic turnover between net protein synthesis and degradation. In human subjects, invasive and non-invasive techniques have been applied to determine their skeletal muscle catabolism of amino acids at rest, during and after different forms of physical exercise and training. The aim of this review is to analyse the turnover flux and the relative oxidation rate of different types of muscle proteins after one bout of exercise as well as after resistance and endurance condition of training. Protein feeding in athletes appears to be a crucial nutrition necessity to promote the maintenance of muscle mass and its adaptation to the need imposed by the imposed technical requirements. In resting human individuals, the recommended protein daily allowance is about 0.8 g (dry weight) kg−1 body weight per 24 h knowing that humans are unable to accumulate protein stores in muscle tissues. Nevertheless, practical feeding recommendations related to regular exercise practice are proposed to athletes by different bodies in order to foster their skills and performance. This review will examine the results obtained under endurance and resistance type of exercise while consuming single or repeated doses of various ingestions of protein products (full meat, essential amino acids, specific amino acids and derivatives, vegetarian food). From the scientific literature, it appears that healthy athletes (and heavy workers) should have a common diet of 1.25 g kg−1 24 h to compensate the exercise training muscle protein degradation and their resynthesis within the following hours. A nitrogen-balance assay would be recommended to avoid any excessive intake of protein. Eventually, a daily equilibrated food intake would be of primer importance versus inadequate absorption of some specific by-products.