bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 2-es típusú diabetes antihyperglykaemiás kezelésének alakulása Magyarországon 2001–2014 között – az Országos Egészségbiztosítási Pénztár adatbázis-elemzésének eredményei
Authors: Jermendy György , Kiss Zoltán , Rokszin György , Abonyi-Tóth Zsolt , Wittmann István , Kempler Péter 
Published: May 2017

Abstract: In the last couple of years, significant developments in antidiabetic treatment have influenced the pharmacological treatment of type 2 diabetes mellitus (T2DM). The aim of this study was to analyze the changes in prescribing patterns of glucose-lowering drugs for T2DM patients in Hungary between 2001 and 2014. The number of patients with newly diagnosed T2DM decreased from 75,700 (2001) to 33,700 (2014), while prevalent T2DM cases continuously increased and plateaued in 2014 with a number of registered patients of 727,000. Sulfonylurea-monotherapy decreased from 64% to 35% while metformin-monotherapy increased from 19% to 42% in this period. The most frequently used drug at first treatment initiation was metformin (66%) and sulfonylurea (16%) as monotherapy in 2014. DPP4-inhibitors were newly administered in 20,362 cases while GLP1-mimetics were newly used by 4,996 patients in 2014. Five years later after initiating sulfonylurea therapy between 2010 and 2014, metformin was more frequently used as second drug (39%) than sulfonylurea in patients with previous metformin treatment (22.9%). The prescribing patterns of glucose-lowering drugs have changed over time in accordance with new guidelines. Further changes in prescribing habits can be expected in the near future. Orv Hetil. 2017; 158(20): 770–778.
Problems of Functional Performance and Space Gradient Organization in the Sidewalk of the Residential Street
Authors: Al-Sanjary Hasan , Ahmad Hatem 
Published: May 2017

Sidewalk space forms one of the key elements in the residential street which is appeared with planning transitions in urban neighborhoods in Iraq over the past century.
Despite the importance of this space as a zone for a range of functional activities that are supposed to achieve within space graduation ensures regulation of the relationship between house resident and road user, but the reality of the housing districts case presents a lot of problems that accompanied the design and furnishing of this space so as to create a number of obvious drawbacks in the effectiveness of its use.
This research aims and through the evaluation of realistic design for local environment of housing in the city of Mosul to extract the most negative aspects of the functional performance of residential street pavement, their causes and down to extract the necessary indicators that can contribute to more effective performance of this space and reinforce its value as a functional and regulatory privacy zone within the housing environment.
Poliquistosis renal bilateral en un bulldog inglés, descripción de un caso
Authors: Guerrero Francesca , Grandez Ricardo , Hinostroza Elizabeth , Salas Elia 
Published: May 2017

Se diagnosticó de poliquistosis renal bilateral (enfermedad renal poliquística) mediante ultrasonografía a un canino bulldog inglés de 4 meses de edad. Las imágenes fueron obtenidas mediante un transductor microconvexo multifrecuencial de 4-10 MHz Sonosite Micromaxx®, con el paciente en recumbencia dorsal. Se tomaron análisis sanguíneos donde se detectó leucocitosis moderada con desviación a la izquierda, anemia normocrómica normocítica, creatinina en 4.6 mg/dl, calcio y fósforo sérico en 10.34 mg/dl y 10.5 mg/dl respectivamente, también se le realizó urianálisis donde se observó peso específico en 1.010, proteinuria, y 30-35 por campo de leucocitos en el sedimento urinario así como presencia de bacterias. El cuadro fue compatible también con falla renal crónica y esto fue corroborado mediante ultrasonografía donde se observaron múltiples nódulos hipoecoicos de 1 a 2 centímetros de diámetro, y con pobre diferenciación córtico medular. El propietario no optó por la eutanasia, sin embargo, la mascota falleció. Este reporte sería el primero en describir un caso de enfermedad renal poliquística en la raza Bulldog inglés en nuestro país.
Developmental, molecular and genetic studies on grapevine response to temperature open breeding strategies for adaptation to warming
Authors: Torregrosa Laurent , Bigard Antoine , Doligez Agnes , Lecourieux David , Rienth Markus , Luchaire Nathalie , Pieri Philippe , Chatbanyong Ratthaphon , Shahood Rezth , Farnos Marc , Roux Catherine , Adiveze Angélique , Pillet Jérémie , Sire Yannick , Zumstein Emmanuelle , Veyret Mélanie , Le Cunff Loic , Lecourieux Fatma , Saurin Nicolas , Muller Bertrand , Ojeda Hernán , Houel Cléa , Péros Jean-Pierre , This Patrice , Pellegrino Anne , Romieu Charles 
Published: May 2017

<p class="Abstract" style="text-align: justify;"><strong>Aim:</strong> In the long term, genetic improvement is one of the major strategies to support sustainable wine production in a changing climate. Over the past 5 years, we have developed an interdisciplinary research program that aimed to: i) characterize the impact of temperature increase sensed by the entire plant or individual bunches on the development and functioning of the plant, ii) identify the physiological and molecular mechanisms regulating the response of vegetative and reproductive development to heat stress and iii) develop tools to map quantitative trait loci (QTLs) of plant and berry development in duly controlled, stable, and contrasting environmental conditions.</p><p class="Abstract" style="text-align: justify;"><strong>Methods and results:</strong> Performing high-throughput genomic analyses combined with the use of innovative experimental designs (fruiting cuttings, microvines, single berry sampling) was critical to decipher the ecophysiological and molecular mechanisms involved in the vine response to high temperature.</p><p class="Abstract" style="text-align: justify;"><strong>Conclusion:</strong> Warming promotes vegetative growth and hampers plant carbon balance, disturbing flower set and young berry development. High temperatures modify primary and secondary fruit metabolisms, desynchronizing sugar and organic acid metabolisms and delaying sugar and polyphenol accumulation during ripening. The study of day and night transcriptomic and proteomic signatures associated with heat highlighted key players of the response to temperature in the fruit. </p><p class="Abstract" style="text-align: justify;"><strong>Significance and impact of the study:</strong> Capitalizing on this knowledge, a new program is being proposed for the selection of cultivars limiting the accumulation of sugars in the berry while maintaining other qualitative compounds.</p>
Modified grape composition under climate change conditions requires adaptations in the vineyard
Authors: Van Leeuwen Cornelis , Destrac-Irvine Agnès 
Published: May 2017

<p style="text-align: justify;"><strong>Aim:</strong> Major effects of climate change are an increase in temperature, a modification in rainfall patterns and an increase in incoming radiations, in particular UV-Bs. Grapevines are highly sensitive to climatic conditions. Hence, plant development, grape ripening and grape composition at ripeness are modified by climate change. Some of these changes are already visible and will be amplified over the coming decades; other effects, although not yet measurable, can be predicted by modeling. The objective of this paper is to assess which modifications in wine quality and typicity can be expected and what levers growers can implement to adapt to this changing situation. </p><p style="text-align: justify;"><strong>Methods and results:</strong> This paper focusses on the effect of temperature, vine water status and UV-B radiation in viticulture. Vine phenology is driven by temperacture. A significant advance in phenology (i.e. budburst, flowering and veraison dates) has been observed since the early 1980’s in most winegrowing regions. The combined effect of advanced phenology and increased temperatures results in warmer conditions during grape ripening. In these conditions, grapes contain more sugar and less organic acids. Composition in secondary metabolites, and in particular aromas and aroma precursors, is dramatically changed. Increased drought, because of lower summer rain and/or because of higher reference evapotranspiration (ET<sub>0</sub>), induces earlier shoot growth cessation, reduced berry size, increased content in skin phenolic compounds, lower malic acid concentrations and modified aroma and aroma precursor profiles. Increased UV-B radiation enhances the accumulation of skin phenolics and modifies aroma and aroma precursor profiles. Over the next decades, an amplification of these trends is highly likely. Major adaptations can be reached though modifications in plant material (grapevine varieties, clones and root stocks), vineyard management techniques (grapevine architecture, canopy management, harvest dates, vineyard floor management, timing of harvest, irrigation) or site selection (altitude, aspect, soil water holding capacity).</p><p style="text-align: justify;"> <strong>Conclusion:</strong> Climate change will induce changes in grape composition which will modify wine quality and typicity. However, these modifications can be limited through adaptations in the vineyard.</p><p style="text-align: justify;"><strong>Significance and impact of the study:</strong> This study assesses the impact of major climatic parameters (temperature, water and radiation) on vine physiology and grape ripening. It addresses the issue of how the expected changes under climate change will impact viticulture. It is shown that appropriate levers do exist to allow growers to adapt to this new situation. Among these, modifications in plant material and viticultural techniques are the most promising tools.</p><div> </div>
Climate vs grapevine pests and diseases worldwide: the first results of a global survey
Authors: Bois Benjamin , Zito S. , Calonnec A. 
Published: May 2017

<p class="Abstract"><strong>Aim:</strong> This paper aimed to address the relationship between grapevine disease, pest occurrences and climate. The extremely large extension of viticulture worldwide offers the possibility to evaluate the impacts of climate variability on many aspects of the grape growing system. For this, we initiated a global survey to retrieve the most important diseases and pests in many grape growing regions worldwide and to identify the risk of exposure to pests and diseases of viticulture as a function of climate.</p><p class="Abstract"><strong>Methods and results:</strong> Based on the answer of respondent about the main reported diseases/pests in their region, a severity index was calculated. Each region was geolocalised and data were compared to the WorldClim gridded climate database to document the range of climate conditions (growing season temperature and rainfall) associated to the main diseases/pests. The potential climatic-induced changes of grapevine disease and pest geography by 2050 are assessed using agro-climate projections from the ARPEGE CNRM model, using the RCP 4.5 scenario. The preliminary results allow to determine the distribution of diseases as function of agroclimatic indicators.</p><p><strong>Conclusion:</strong> While the distribution of diseases differs according to the region of the world, the current analysis suggests that mildews remain the major phytosanitary threat in most of the regions. Powdery mildew, trunk diseases and viruses were reported in extremely diverse climatic conditions, including intermediate and wet regions. </p><p><strong>Significance and impact of the study:</strong> This paper present an original methodology to address the relationship between grapevine disease and pest occurrences and climate. Such documentation is scarce in the current literature. Further analysis is currently being performed, including additional survey answers, climate indices and supplementary data collected (spatial extension, frequency of treatments…) to better depict the challenges of grapevine phytosanitary management in a changing climate.</p>
Adapting plant material to face water stress in vineyards: which physiological targets for an optimal control of plant water status?
Authors: Simonneau T. , Lebon E. , Coupel-Ledru A. , Marguerit E. , Rossdeutsch L. , Ollat N. 
Published: May 2017

<p class="Abstract" style="text-align: justify;"><strong>Aims:</strong> Water scarcity, associated with climate change, is a particular threat to the sustainability of viticulture in present areas of cultivation, usually prone to drought. Breeding grapevine for reduced water use, better water extraction and maintained production (i.e., high water use efficiency) is therefore of major interest.</p><p class="Abstract" style="text-align: justify;"><strong>Methods and results:</strong> This requires a comprehensive knowledge of the physiological impacts of drought on yield and quality. Attention should be paid to those mechanisms involved in the regulation of water status in plant tissues, as it is the primary parameter affected by drought. Transpiration rate, which has a major influence on plant water status, should therefore receive special attention in breeding programs. Beyond scions, the role of rootstocks, which have been largely introduced in vineyards, should be investigated further as it determines water extraction capacity and could modify water balance in grafted plants.</p><p class="Abstract" style="text-align: justify;"><strong>Conclusion:</strong> Here we review recent advances in the characterization of genetic variability in the control of water use and water status, whether induced by rootstock or scion.</p><p class="Abstract" style="text-align: justify;"><strong>Significance and impact of the study: </strong>This review should help scientists in choosing the relevant physiological targets in their research on grapevine tolerance to drought, whether for breeding prospects or new management practices.</p>
Development of an Environmentally Friendly Oil Based Drilling Fluid Using Castor Oil with Polar Activator and In Presence of Strong Bases Lime
Authors: Bastidas H. A. , Perez J. S. , Castellanos C. Vargas 
Published: May 2017

Abstract
The behavior of two Castor oil based muds (OBM) prepared with additives marketed in Colombia is observed, the concentrations of the additives are the same for both fluids with the difference that one has as rheological modifier a polar activator and the other uses lime. These ones are subjected to rolling up for 16 hours at temperatures of 65°C, 80°C and 120°C. The rheological behavior of the fluids is analyzed according to API RP 13B-2 standard before and after rolling up at different temperatures. According to the results of this investigation, it is discovered that the fluids behavior in the presence of strong bases like lime becomes stable as the rolling up temperature increases until 120°C, whereas when there is no lime in the composition the behavior is more constant in all the cases and the change of viscosity with respect to the initial viscosity is smaller. The presence of strong bases tends to decrease their percentage of fatty acids 17% at 65°C and increase 6% at 120°C with respect to the fluids with polar activator rolled up at the same conditions. To see if the fluids can be categorized as environmentally friendly, we proceeded to evaluate the impact of the fluids developed in the survival of red tilapia fingerlings in a water body simulated in the laboratory. The minimum conditions to die at least 50% of the population of red tilapia fingerlings was 96 hours of exposure to fluids at a concentration of 5000ppm.
Identification of CO2 with Magnetic Resonance Key to Understanding Production Behavior in Campo Palo Azul, Ecuador: A Case Study
Authors: Ramirez N. X. , Roldan J. E. , Delgado B. , Cuenca D. 
Published: May 2017

Abstract
This paper presents a case study focusing on the identification of CO2 in the Hollin reservoir, based on nuclear magnetic resonance (NMR) responses, its effect on petrophysical parameters, and the negative effect on production wells. The paper also discusses the strong relationship between the high CO2 concentration in the reservoir fluids and its effect on the formation damage resulting from pore throat plugging from organic and inorganic compounds.
After NMR processing, it was possible to identify the CO2 response on porosity related to low hydrogen index; the PVT analysis reveals approximately 75% of CO2 in the reservoir conditions and more than 95% of CO2 in the surface conditions. Asphaltene stability was evaluated through four methods, including the Leontaritis method, colloidal stability index, Stankiewicz method, and stability crossplot (SCP), which enabled the determination of an unstable probability by more than 75%. Palo Azul wells have been completed with production enhancement techniques, such as fracturing, to minimize the formation damage and its negative production effect; until now, however, the unique hypothesis considered formation damage to be related to fine-grain migration without considering that the primary problem could be connected to asphaltene stability. The deposition of the asphaltene can plug pore throats, reducing wellbore permeability and dramatically reducing fracture wings conductivity.
This case study provides several important contributions. First, NMR results were successfully used in the Oriente basin of Ecuador to identify reservoirs with high concentrations of CO2. Second, four different diagnostic methods were used to determine asphaltene stability; this has altered common paradigms regarding production reservoir behavior. Finally, this case study enabled the development of a new technical hypothesis concerning additional factors that can contribute to formation damage in the Hollin reservoir.
New Borehole Imaging for OBM Systems. Auca Mahuida Volcano and Las Manadas Fields, Neuquen, Argentina
Authors: Mallimaci D. , Ribas S. , Paris M. , Grisolia J. , Crespo G. 
Published: May 2017

Abstract
The Auca Mahuida Volcano and Las Manadas field produces oil and gas from the Mulichinco, Lower Centenario and Rayoso formations. However this high quality reservoir has been severely damaged due to volcanic activity.
This volcanism occurred after the main hydrocarbon migration and trapping, although there are hydraulically isolated bodies related to the igneous intrusions, confirmed from pressure testing and the distribution of the fluid along the stratigraphy column. The attitude and distribution of these intrusions in the reservoir is not generally known in part due to the lack of the surface seismic over this geologically complicated area.
The big challenge is to be able to accurately identify and rank the intrusive igneous features such as dykes, sills, laccolith and other geological features.
A new borehole image was introduced in Argentina for oil based mud systems. It has very good coverage with 80% in 8 inch wells. It is composed of 6 pads mounted in 6 independent articulated arms, each pad has 10 sensors resulting 60 micro-resistivity measurements. This tool works on different frequencies for different formation resistivity range. Depending on the known resistivity two frequencies can be simultaneously selected to acquire two images in one single pass. Recommended logging speed is 5.5 m/min.
As a result of the operations more than 2000 meters have been logged with high quality borehole imaging. In spite of hostile weather conditions and because it is a natural protected area, there were no incidents registered during these jobs.
At this point of the project dykes seem to follow pre-existing fractures to intrude the formations so the recognition of the fracture attitude is very important to prevent those intrusions at depths where the oil and gas is trapped.
This information was considered as a high value to improve the existing geological model, providing knowledge about the complex net of intrusive bodies by the accurate recognition of the type of intrusion and its attitude close to the borehole.
Thermodynamic Behavior of Olefin and Methane Mixtures Applied to Synthetic Drilling Fluids Well Control
Authors: Marques D. C. , Ribeiro P. R. , Santos O. L. , Lomba R. F. 
Published: May 2017

Abstract
The pre-salt discoveries in deep water have evidenced a challenging environment for drilling operations because of the technical demand and restriction and also environmental regulations fomenting technological development.
Inaccurate estimation of the pressure could lead to drilling problems such as kick, lost circulation and wellbore instability. In this context, understanding the drilling fluid and gas formation mixture behavior is essential in situations of gas influx from the formation into the wellbore. These evidence the drilling fluids importance for the drilling operational efficiency, safety and cost reduction.
Since the synthetic based drilling fluids are more sensitive to the pressure and temperature variations than water based drilling fluids, the effect of pressure, temperature and mixture composition on the thermodynamic properties such as density, formation volume factor, solubility ratio and saturation pressure were determined based on PVT (pressure/temperature/volume) experimental measurements for methane and olefin mixtures. Those properties are crucial for the mixture volumetric behavior knowledge at downhole conditions especially when gas enters into the wellbore.
The experiments were conducted in isothermal conditions and a gas enrichment experimental procedure was applied. The temperature was set at a range between 25°C and 80°C while the gas molar fraction ranged from 30% to 50% and pressures up to 70 MPa.
Additionally, the data collected was compared with the teamwork database for methane and n-paraffin mixtures and methane and ester mixtures. According to the literature, olefins show less toxicity and better biodegrability when compared to isomerized paraffins and esters, therefore olefins fit in with the new requirements present by the Brazilian Institute of Environment and Renewable Natural Resources (IBAMA), which restricted the disposal of cuttings associated with paraffins in offshore operations.
Moreover, as each base has its own particularity, the findings exhibited the importance of the methane and olefin mixtures behavior knowledge at downhole conditions to guarantee the operational safety and efficiency. The experimental data will be essential to bring well control software up to date, which helps the decision-making of the engineers during well control.
Downhole Linear Reducer Application for Rod Load Optimization
Authors: Dominguez E. , Yorio P. , Ferrigno E. , Piña J. L. , Somoza M. 
Published: May 2017

Abstract
The present work aims to expose the study and development of a potentially disruptive change of focus in the mechanical sucker rod artificial lift system. This is a new solution based on the installation of a linear speed reducer located at the bottom of the well between the pump and the rods. This new configuration pursues the goal of dramatically reducing loads on the rod string, surface equipment and power motor, thus allowing to expand, in efficiency and field of application, the limits of the sucker rod pumping, and in some cases of the artificial lift systems as a whole.