bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of deamidation‐induced modification on umami and bitter taste of wheat gluten hydrolysates
Authors: Liu Bo‐Ye , Zhu Ke‐Xue , Guo Xiao‐Na , Peng Wei , Zhou Hui‐Ming 
Published: November 2016

AbstractBACKGROUNDBitter taste is the main limiting factor for various applications of protein hydrolysates. Frequently used physicochemical methods for debittering protein hydrolysates come with some undesired side effects. Deamidation‐induced modification would be a very promising technique to improve the flavor of wheat gluten hydrolysates (WGHs). This study was designed to determine the effect of deamidation with certain enzymes or acid treatment on the chemical composition, bitterness and umami properties of WGHs. The difference between umami peptide and free glutamic acid on the suppression of bitterness is emphatically discussed. The optimal scheme is proposed based on the flavor of WGHs and the yield of peptides.RESULTSThe generation of umami substances suppressed bitter signal transduction. When the content of umami substances was relatively high, the umami‐enhancing properties of umami peptides were obviously effective. The intensity of umami taste was high enough to further suppress bitter taste in the course of neurocognitive functioning.CONCLUSIONWhen WGHs were treated with Glutaminase for 180 min, the umami taste score increased from 1.62 to 4.27 and the bitter taste score decreased from 1.33 to 0.65. © 2016 Society of Chemical Industry
Clinical auditing as an instrument for quality improvement in breast cancer care in the Netherlands: The national NABON Breast Cancer Audit
Authors: van Bommel Annelotte C.M. , Spronk Pauline E.R. , Vrancken Peeters Marie‐Jeanne T.F.D. , Jager Agnes , Lobbes Marc , Maduro John H. , Mureau Marc A.M. , Schreuder Kay , Smorenburg Carolien H. , Verloop Janneke , Westenend Pieter J. , Wouters Michel W.J.M. , Siesling Sabine , Tjan ‐ Heijnen Vivianne C.G. , van Dalen Thijs ,   On behalf of the NABON Breast Cancer Audit
Published: November 2016

BackgroundIn 2011, the NABON Breast Cancer Audit (NBCA) was instituted as a nation‐wide audit to address quality of breast cancer care and guideline adherence in the Netherlands. The development of the NBCA and the results of 4 years of auditing are described.MethodsClinical and pathological characteristics of patients diagnosed with invasive breast cancer or in situ carcinoma (DCIS) and information regarding diagnosis and treatment are collected in all hospitals (n = 92) in the Netherlands. Thirty‐two quality indicators measuring care structure, processes and outcomes were evaluated over time and compared between hospitals.ResultsThe NBCA contains data of 56,927 patients (7,649 DCIS and 49,073 invasive cancers). Patients being discussed in pre‐ and post‐operative multidisciplinary team meetings improved (2011: 83% and 91%; 2014: 98% and 99%, respectively) over the years. Tumour margin positivity rates after breast‐conserving surgery for invasive cancer requiring re‐operation were consistently low (∼5%). Other indicators, for example, the use of an MRI‐scan prior to surgery or immediate breast reconstruction following mastectomy showed considerable hospital variation.ConclusionsResults shown an overall high quality of breast cancer care in all hospitals in the Netherlands. For most quality indicators improvement was seen over time, while some indicators showed yet unexplained variation. J. Surg. Oncol. 2017;115:243–249. © 2016 Wiley Periodicals, Inc.
Network Formation and Mechanical Properties of Telechelic Associating Polymers with Fixed Junction Multiplicity
Authors: Ozaki Hiroto , Koga Tsuyoshi 
Published: November 2016

A statistical–mechanical theory of thermoreversible gelation which is formed by monodisperse telechelic associating polymers with junction multiplicity of three is developed. In the present theory, the effect of loop formation is considered. Using the theory, the properties of the system are obtained, such as the state of association of polymers, the sol–gel transition line, and the number concentration of elastically effective chains. In addition, a Monte Carlo simulation of a bead‐spring model of monodisperse telechelic associating polymers is performed. The simulation results are in good agreement with the present theoretical results. Furthermore, the shear modulus is calculated by an application of phantom network theory and compared with the experimental data. The theoretical results agree well with the experimental results. It is shown that the loop formation occurs especially in dilute regime and causes the decrease of the modulus in the regime.
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Spatial resolution and velocity field improvement of 4D‐flow MRI
Authors: Callaghan Fraser M. , Grieve Stuart M. 
Published: November 2016

Purpose4D‐flow MRI obtains a time‐dependent 3D velocity field; however, its use for the calculation of higher‐order parameters is limited by noise. We present an algorithm for denoising 4D‐flow data.Theory and MethodsBy integrating a velocity field and eliminating streamlines in noisy flow, depicted by high curvature, a denoised dataset may be extracted. This method, defined as the velocity field improvement (VFIT) algorithm, was validated in an analytical dataset and using in vivo data in comparison with a computation fluid dynamics (CFD) simulation. As a proof of principal, wall shear stress (WSS) measurements in the descending aorta were compared with those defined by CFD.ResultsThe VFIT algorithm achieved a >100% noise reduction of a corrupted analytical dataset. In addition, 4D‐flow data were cleaned to show improved spatial resolution and near wall velocity representation. WSS measures compared well with CFD data and bulk flow dynamics were retained (<2% difference in flow measurements).ConclusionThis study presents a method for denoising 4D‐flow datasets with improved spatial resolution. Bulk flow dynamics are accurately conserved while velocity and velocity gradient fields are improved; this is important in the calculation of higher‐order parameters such as WSS, which are shown to be more comparable to CFD measures. Magn Reson Med 78:1959–1968, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
What happens when N = 1 and you want plus 1?
Authors: Might Matthew , Might Cristina Casanova 
Published: November 2016

AbstractWe present a personal case study of what happens when a family has a child with an undiagnosed genetic disorder yet wishes to have more children free of the disease. After an intractable diagnostic odyssey for our oldest son, our family turned to exome sequencing. Exome sequencing found likely pathogenic variants of uncertain significance in the gene NGLY1. We used social media to uncover more cases for the newly discovered disorder and confirm the diagnosis in the process. With a diagnosis, we then explored and experienced a broad range of options for conceiving a child free of the disorder. Our success in having another child free of the disorder created a pathway for other families in our newly discovered disease community to do the same. © 2016 John Wiley & Sons, Ltd.
Group therapy processes and treatment outcomes in 2 couple‐focused group interventions for breast cancer patients
Authors: Manne Sharon L. , Kashy Deborah , Siegel Scott D. , Heckman Carolyn J. 
Published: November 2016

AbstractBackgroundThere has been little attention paid to the role of therapeutic processes in group therapy outcomes for cancer patients participating in group. The goal was to evaluate the contribution of 3 group processes—group climate (conflict, engagement, and avoidance) working alliance and therapeutic realizations—to the outcomes of 2 couple‐focused approaches to group treatment.MethodsThree hundred and two women with early stage breast cancer and their partners were randomized to one of 2 conditions: an 8‐session enhanced couple‐focused group (ECG) intervention or a couples' support group participated. Couples completed measures of depressive symptoms and well‐being before and 6 months after group. Group process measures were completed after sessions 4 and 8.ResultsSupport group participants (both patients and partners) perceived higher engagement and less avoidance than ECG participants. Conflict, working alliance, and therapeutic realizations did not differ. Group engagement, working alliance, and therapeutic realizations increased, and group conflict decreased over the course of both treatments. Greater conflict was associated with more posttreatment anxiety and lower well‐being, and engagement was associated with higher posttreatment well‐being. Patients whose partners reported higher conflict reported greater posttreatment anxiety. Working alliance was associated with posttreatment anxiety for ECG patients and with well‐being among participants whose partners reported higher working alliance.ConclusionsFostering a positive group environment bolsters treatment efficacy for women with early stage breast cancer and their partners attending couple‐focused groups. Facilitating the leader‐member alliance bolsters treatment efficacy. Improving engagement with one member of a couple impacts the other member.
Detection and Analysis of Ground Deformation in Permafrost Environments
Authors: Arenson Lukas U. , Kääb Andreas , O'Sullivan Antóin 
Published: November 2016

AbstractIn situ monitoring of periglacial dynamics is essential for the study of periglacial morphology and the design of mitigation and adaptation measures for infrastructure in permafrost zones. Evaluation of future effects of climate change on and from the periglacial environment requires understanding of surficial and internal deformation processes. Monitoring of internal deformation is still uncommon, primarily because of high costs. By contrast, major advancements in remote‐sensing technologies allow detailed assessment of surface deformation for large study areas. Technological advancements are anticipated to enhance spatial and temporal resolution, lighten sensors and improve unmanned aerial vehicles technology. The last of these will facilitate and reduce costs for data collection in remote areas under harsh climatic conditions. Increasing application of Structure‐from‐Motion, a photogrammetric image analysis technique, is anticipated, due to its precision, resolution, ease of usage and low cost. Copyright © 2016 John Wiley & Sons, Ltd.
Anisotropic nature of hole g‐factor in individual InAs quantum rings
Authors: Kaji R. , Tominaga T. , Wu Y.‐N. , Wu M.‐F. , Cheng S.‐J. , Adachi S. 
Published: November 2016

AbstractThe in‐plane g‐factors of electron and hole spins (, ) confined in the individual InAs/GaAs quantum rings (QRs) were investigated by using experimental and theoretical approaches. From the measurements, we found that the experimentally obtained varies largely from QR to QR, while the variation in is small. In addition, the in‐plane () and the out‐of‐plane () anisotropies in hole g‐factor were obviously confirmed while the electron g‐factor exhibits isotropic natures in both cases. From the model calculations, the effects of the shape anisotropies and the uniaxial stress were examined. The shape anisotropy in QRs modifies the spatial distributions of hole wavefunctions. Thus, it brings the resultant changes in the degree of valence‐band mixing and , and combined with uniaxial stress, a larger modulation in was achieved. Although more detailed discussions are necessary at this stage, our findings will give valuable information for the g‐factor control in semiconductor nanostructures.
Reputation trust mechanism under the organizational‐based access control model
Authors: Toumi Khalifa , Sfar Hela , Garcia Alfaro Joaquin 
Published: November 2016

AbstractThe spread of high‐speed networks changes the way in which organizations manage information. Distributed environments, such as multi‐cloud environments, can be exploited by users belonging to different organizations. Companies are realizing that they can achieve significant cost savings by outsourcing some of their information technology environments to specialized service companies. This rapid transition has introduced a number of security risks and challenges. The resulting environment cannot succeed at addressing them without the use of access control policies and the definition of trust mechanisms. Access control ontologies, as a structured way to represent real word elements, are widely employed for making the security interoperable and understandable. Ontologies that have been built for this aim suffer from the lack of crucial elements for distributed environments. In this paper, we tackle the problem of trust‐based access control models. We define a list of trust elements that should be integrated into any access control ontology. We also provide a mapping technique that permits the exchange of trust information. Based on these two contributions, our reputation mechanism, that builds upon the organization‐based access control model (OrBAC), is created. To prove the efficiency of our proposal, we test it in a multi‐cloud environment. Then, we conduct a set of experiments that show the high accuracy level of our system. Copyright © 2016 John Wiley & Sons, Ltd.
Mental health of women entering fertility treatment: What role do age and internal resources play?
Authors: Ben Shlomo Shirley , Skvirsky Vera , Taubman – Ben‐Ari Orit , Azuri Yoseph , Horowitz Eran 
Published: November 2016

AbstractDrawing on Lazarus and Folkman's (1984) model of stress and coping, the study aimed at (a) examining the associations between the mental health of women entering fertility treatment and their internal resources (hope and two aspects of self‐consciousness: reflection and rumination); (b) indicating whether mental health is associated with age (above or below 35), and whether this association is mediated by the internal resources.The sample consisted of 137 women (76 aged 20–34; 61 aged 35–44) at the start of fertility treatment who completed a series of self‐report questionnaires.Results indicated that younger women reported higher distress and rumination than older women. Higher hope was associated with greater well‐being, and higher rumination was associated with greater distress. Furthermore, hope and rumination were found to mediate the association between age and mental health. These findings highlight the importance of developing age‐based interventions for women entering fertility treatment, aimed at strengthening their resilience to effectively cope with the demanding process ahead.
Hardiness, avoidance coping, and alcohol consumption in war veterans: A moderated‐mediation study
Authors: Bartone Paul T. , Johnsen Bjorn H. , Eid Jarle , Hystad Sigurd W. , Laberg Jon C. 
Published: November 2016

AbstractMilitary personnel often engage in excessive alcohol use after returning from deployments. Thus far, research has paid scant attention to personality factors that may increase or diminish the risk for increased alcohol consumption in this population. The present study explores how psychological hardiness, avoidance coping, and stress exposure may interact to influence alcohol consumption patterns in soldiers following deployment. U.S. Army National Guard soldiers (N = 357) were surveyed shortly after returning from combat operations in Afghanistan. Conditional process analysis was used to test for mediation and moderation effects. Mediation effects were further tested in a replication sample of Norwegian Army soldiers (N = 230) deployed to Kosovo. Findings show that hardiness is a significant (negative) predictor of increased alcohol use and that this relation is mediated by avoidance coping. Further, this effect was moderated by combat stress exposure in the U.S. sample, such that the mediation is stronger for those with greater exposure (moderated‐mediation). Avoidance coping also mediated the effects of hardiness on alcohol consumption in the Norwegian sample. These findings suggest that avoidance coping and hardiness may be fruitful areas for interventions aimed at reducing risky drinking in high‐stress groups like the military.
Financial strain, dyadic coping, relationship satisfaction, and psychological distress: A dyadic mediation study in Greek couples
Authors: Karademas Evangelos C. , Roussi Pagona 
Published: November 2016

AbstractFinancial strain typically has a severe impact on a couple's functioning and the well‐being of its members. In this study, we examined the indirect relation of financial strain to partners' relationship satisfaction and psychological distress, using dyadic coping as a mediator, in a sample of Greek couples. One hundred and eighteen couples participated in a cross‐sectional study. Perceived material loss in the past and perceived threat of loss in the future were used as financial strain indices. The actor–partner interdependence mediation model was employed to test for the mediation hypotheses. According to the results, the complete mediation (i.e., only indirect) effects models showed an unsatisfactory fit to the data and were rejected. The partial mediation actor–partner interdependence mediation model revealed several statistically significant direct and indirect (actor and partner) effects of the financial strain indices. The results provide more support to the hypothesized mediated impact of financial strain on partners' relationship satisfaction than on psychological distress. The findings underline the importance of dyadic coping for couple's adaptation to financial strain. They also point to the need to examine responses to stress at a dyadic level.
Self‐Assembly of Bolaamphiphilic Molecules
Authors: Dhasaiyan Prabhu , Prasad Bhagavatula L. V. 
Published: November 2016

AbstractThe current buzzword in science and technology is self‐assembly and molecular self‐assembly is one of the most prominent fields as far as research in chemical and biological sciences is concerned. Generally, self‐assembly of molecules occurs through weak non‐covalent interactions like hydrogen bonding, π–π stacking, hydrophobic effects, etc. Inspired by many natural systems consisting of self‐assembled structures, scientists have been trying to understand their formation and mimic such processes in the laboratory to create functional “smart” materials, which respond to temperature, light, pH, electromagnetic field, mechanical stress, and/or chemical stimuli. These responses are usually manifested as remarkable changes from the molecular (e. g., conformational state, hierarchical order) to the macroscopic level (e. g., shape, surface properties). Many molecules such as peptides, viruses, and surfactants are known to self‐assemble into different structures. Among them, glycolipids are the new entries in the area of molecules that are being investigated for their self‐assembly characteristics. Among the different classes of glycolipids like rhamnolipids and trehalose lipids, owing to their biological preparations and their structural novelty, sophorolipids (SLs) are evoking greater interest among researchers. Sophorolipids are a class of asymmetric bolas bearing COOH groups at one end and sophorose (dimeric glucose linked by an unusual β(1→2) linkage). The extreme membrane stability of Archaea, attributed to the membrane‐spanning bolas (tetraether glycolipids), has inspired chemists to unravel the molecular designs that underpin the self‐assembly of bolaamphiphilic molecules. Apart from these self‐assembled structures, bolaamphiphiles find applications in many fields such as drug delivery, membrane mimicking, siRNA therapies, etc. The first part of this Personal Account presents some possible self‐assembled structures of bolaamphiphiles and their mechanism of formation. The later part covers our work on one of the typical bolaamphiphiles known as sophorolipids.
Divergent Total Synthesis of Atisane‐Type Diterpenoids
Authors: Zhu Guili , Wadavrao Sachin B. , Liu Bo 
Published: November 2016

AbstractAtisane‐type diterpenoids are the principal constituent of tetracyclic C20‐diterpenoids, widely isolated from the plant kingdom with varying degrees of structural complexity and pharmacological activity. The tetracarbocyclic system with the unique bicyclo[2.2.2]octane skeleton of this natural product family has generated interest within the synthetic community. Divergent total synthesis is an effective tactic to synthesize several atisane‐type diterpenoids using structural interconversion from a common intermediate. This account summarizes the divergent total synthesis of atisane‐type diterpenoids.
Introducing Barium in Transition Metal Oxide Frameworks: Impact upon Superconductivity, Magnetism, Multiferroism and Oxygen Diffusion and Storage
Authors: Raveau Bernard 
Published: November 2016

AbstractThe role of barium in the structural chemistry of some transition metal oxides of the series “Cu, Mn, Fe,Co” is reviewed, based on its size effect and its particular chemical bonding. Its impact upon various properties, superconductivity, magnetism, multiferroism, oxygen storage is emphasized.
Operational semantics of resolution and productivity in Horn clause logic
Authors: Fu Peng , Komendantskaya Ekaterina 
Published: November 2016

Abstract

This paper presents a study of operational and type-theoretic properties of different resolution strategies in Horn clause logic. We distinguish four different kinds of resolution: resolution by unification (SLD-resolution), resolution by term-matching, the recently introduced structural resolution, and partial (or lazy) resolution. We express them all uniformly as abstract reduction systems, which allows us to undertake a thorough comparative analysis of their properties. To match this small-step semantics, we propose to take Howard’s System
H
as a type-theoretic semantic counterpart. Using System
H
, we interpret Horn formulas as types, and a derivation for a given formula as the proof term inhabiting the type given by the formula. We prove soundness of these abstract reduction systems relative to System
H
, and we show completeness of SLD-resolution and structural resolution relative to System
H
. We identify conditions under which structural resolution is operationally equivalent to SLD-resolution. We show correspondence between term-matching resolution for Horn clause programs without existential variables and term rewriting.
Mukoviszidose
Authors: Rath Matthias , Najm Juliane , Gilberg Eberhard , Felbor Ute 
Published: November 2016

ZusammenfassungDie Mukoviszidose gehört mit einer Inzidenz von etwa 1:3300 bis 1:4800 Neugeborenen zu den häufigsten autosomal-rezessiv erblichen Erkrankungen in Deutschland und ist mit einer hohen Morbidität und Mortalität assoziiert. Um die möglichst frühzeitige Einleitung einer Therapie zu ermöglichen, wurde mit der am 1. September 2016 in Kraft getretenen Novellierung der Richtlinie über die Früherkennung von Krankheiten bei Kindern bis zur Vollendung des 6. Lebensjahres durch den Gemeinsamen Bundesausschuss die Einführung eines Screenings auf Mukoviszidose im Neugeborenenalter beschlossen. Ferner konnte durch interdisziplinäre Behandlungskonzepte u. a. in spezialisierten Mukoviszidosezentren die Lebenserwartung in den letzten Jahrzehnten deutlich gesteigert werden. Mit der Entwicklung und zunehmenden Markteinführung mutationsspezifischer Therapien besteht erstmals die Möglichkeit, direkt in die Pathophysiologie der Mukoviszidose einzugreifen.