bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using ChatGPT and determinologisation to enhance understanding of lung cancer information
Authors: Varela Salinas María-José , Godoy Lorenzatto Adriana 
Published: October 2024

Abstract
Lung cancer is associated to high mortality rates and has a large impact on the quality of life of patients and families, who therefore need suitable information to deal with the situation. However, information provided by health services is often not adapted to lay users and retains a considerable number of technicalities that impair comprehensibility. Accessibility, a concept receiving increasing attention, not only involves physical access but also understanding relevant information when it comes to the medical setting. One of the main intralingual translation procedures used to adapt specialised text is determinologisation, which comprises strategies like using common-speech synonyms, explanations, examples, etc. Recent artificial intelligence generative models offer a promising tool to produce texts at different specialisation levels. In this study, we evaluated the capacity of ChatGPT for determinologisation of terms extracted from a corpus of patient-oriented lung-cancer texts and compared the results with reliable patient-oriented online sources. ChatGPT produced definitions and context information similar to those of the online sources in a very short amount of time. However, both the choice of suitable input prompts and the post-edition process necessary to produce quality final texts on lung-cancer information still required the supervision of human experts.
Trapezoidal and Simpson’s methods with a random design
Authors: Kaeshammer Thibaud , Paroissin Christian , Urmeneta Herna 
Published: October 2024

Abstract
The aim of the present paper is first to propose a state-of-art of this domain.
Second, some convergence results are established in the case of the Dirichlet distribution.
This distribution has the advantage to include both the uniform case and the deterministic one.
In a first part, the Dirichlet distribution is defined and some properties are supplied.
In a second part, new results are established in connexion with former theorems.
Stretchable plasmonic metasurfaces for deformation monitoring
Authors: Li Peiyang , Gao Kaikai , Ma Ruize , Pan Kai , Li Dong , Liu Feng , Li Peng , Gan Xuetao , Zhao Jianlin , Wen Dandan 
Published: October 2024

Abstract
Metasurfaces have recently gained significant attention due to the strong capacity in light field manipulation. However, most traditional metasurfaces are fabricated on rigid substrates, which fix their functionality after fabrication and limit their applications in dynamic measurement fields. In this work, we designed and fabricated a silver metasurface embedded in a stretchable substrate for sensing applications. This metasurface can generate different point cloud patterns under varying stretch ratios when illuminated by a laser beam. By collecting and analyzing the patterns, we can precisely reconstruct the deformation of the metasurface. Furthermore, the sample exhibits excellent performance under incident light of various wavelengths. These results pave the way for developing microdevices with novel capabilities based on flexible metamaterials.
Build muscles and protect myelin
Authors: Bose Ahana , Pahan Kalipada 
Published: October 2024

Abstract
Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease of the central nervous system (CNS) in which a CNS-driven immune response destroys myelin, leading to wide range of symptoms including numbness and tingling, vision problems, mobility impairment, etc. Oligodendrocytes are the myelinating cells in the CNS, which are generated from oligodendroglial progenitor cells (OPCs) via differentiation. However, for multiple reasons, OPCs fail to differentiate to oligodendrocytes in MS and as a result, stimulating the differentiation of OPCs to oligodendrocytes is considered beneficial for MS. The β-hydroxy β-methylbutyrate (HMB) is a widely-used muscle-building supplement in human and recently it has been shown that low-dose HMB is capable of stimulating the differentiation of cultured OPCs to oligodendrocytes for remyelination. Moreover, other causes of autoimmune demyelination are the decrease and/or suppression of Foxp3-expressing anti-autoimmune regulatory T cells (Tregs) and upregulation of autoimmune T-helper 1(Th1) and Th17 cells. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS in which the autoimmune demyelination is nicely visible. It has been reported that in EAE mice, oral HMB upregulates Tregs and decreases Th1 and Th17 responses, leading to remyelination in the CNS. Here, we analyze these newly-described features of HMB, highlighting the putative promyelinating nature of this supplement.
Bibliometric analysis of stone column research trends: A Web of Science perspective
Authors: Kumar Neeraj , Kumar Rakesh 
Published: October 2024

Abstract
Stone columns have garnered significant interest in geotechnical engineering as an effective ground improvement technique for enhancing the load-bearing capacity and mitigating settlement issues in soft soils. This study presents a comprehensive bibliometric analysis of scholarly literature on stone columns, utilizing data from the Web of Science database spanning from 1975 to 2023. The analysis aims to provide insights into publication trends, influential journals, key research institutions and authors, geographical distributions, and emerging themes in this domain. Through a systematic data curation process, 505 relevant publications were analyzed using Excel and VOSviewer software. The findings reveal a notable emphasis on geosynthetic encasements, load-settlement behavior, and soft soil reinforcement, with China being a major contributor. Over the past 48 years, the research has evolved from static loading to dynamic loading, sustainable structures, and artificial intelligence applications, as evidenced by the highly cited publications. This study maps the development, current state, and potential future directions of stone column research, serving as a valuable resource for researchers and practitioners in geotechnical engineering.
‘Direct’ elicitation and phonological argumentation
Authors: Himmelmann Nikolaus P. 
Published: October 2024

Abstract
Linguistic elicitation is a kind of behavioral experiment. It remains an important source for phonological (and more generally, grammatical) argumentation even if it does not meet all the requirements for a proper behavioral experiment (in terms of the number of participants, for example). While the basic analysis proposed for Budai Rukai syllable structure is convincing, questions arise with regard to how the very basic notions syllable and stress are interpreted in the target article. Furthermore, one would wish for a more detailed argument regarding the analysis of echo vowels and phonetic glides.
Intuition, intonation, inconsistency, and innateness
Authors: Myers James 
Published: October 2024

Abstract
Macaulay has performed a great service by pointing out unfounded leaps of logic in the syllable sections of descriptive grammars, but the auxiliary hypotheses that underlie such leaps require close scrutiny everywhere, including in his own argument: intuitions are more reliable than he claims, intonation is less reliable than he assumes, inconsistencies cannot be resolved by simply ignoring certain types of evidence, and innateness considerations qualify all linguistic argumentation.
Preparation and stability of lipid nanoparticles excluding 1,2-distearoyl-sn-glycero-3-phosphocholine
Authors: Jung Hye Yoon , Kim Tae Hoon , Hadinoto Kunn , Park Jin-Won 
Published: October 2024

Abstract
Since 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), the component to keep structure of mRNA-lipid nanoparticle (LNP), is known to cause adverse effects, the replacement of DSPC with the combination of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) and 1-stearoyl-2-hydroxy-sn-glycero-3-phospho ethanolamine (SHPE) was investigated. Specifically, when DSPC of mRNA-LNP was replaced by an 11:1 ratio of DSPE:SHPE, it was found that the size and permeability of mRNA-LNP were the same as those of mRNA-LNP containing DSPC in terms of stability. This result appears to be due to lipid geometry – the ratio of lipid volume to head group area and lipid length.
Genotype/phenotype correlations in multiple endocrine neoplasia type 2
Authors: Castinetti Frederic , Eng Charis 
Published: October 2024

Graphical abstract

Abstract
Multiple endocrine neoplasia type 2 (MEN 2) is a rare hereditary endocrine tumor syndrome caused by mutations in the rearranged during transfection (RET) gene. MEN 2 is divided into two main entities, MEN 2A and MEN 2B, both of which present with medullary thyroid cancer (MTC) in approximately 100% of cases and pheochromocytoma in 50% of cases. Specific RET mutations are associated with a risk of early onset of MTC, from 1 year of age (highest risk) to 5 years of age (high risk). This risk defines the optimal timing for thyroidectomy, ideally at an age when the disease has not spread. This is the most important genotype-phenotype correlation observed in MEN 2. Specific RET mutations also define the penetrance of pheochromocytoma. However, despite the presence of these highest/high-risk variants, some patients unexpectedly present with non-aggressive MTC or never present with pheochromocytoma, suggesting that factors other than the major RET variant may modify the natural history and genotype-phenotype correlations. Improving our understanding of the genotype-phenotype correlations would allow individualizing the management and follow-up of patients with MEN 2. The aim of this brief review is to discuss the main genotype-phenotype correlations in MEN 2 and the potential factors that might influence these correlations.
Pueraria lobata extract ameliorates D-GalN/LPS-induced liver injury through targeting TLR4/NF-κB signalling pathway and regulating gut microbiota
Authors: Ge J. , Li S. , Li J. , Zhang Y. 
Published: October 2024

AbstractKudzu root (Pueraria lobata), known for its dual role as a medicinal herb and food ingredient, has proven anti-inflammatory and antioxidant properties. This study explored the effects of P. lobata extract (PLE) on D-galactose/lipopolysaccharide (D-GalN/LPS)-induced liver inflammation and oxidative stress in mice, along with its impact on gut microbiota. The in vivo studies indicated that PLE significantly reduced hepatic levels of pro-inflammatory cytokines (tumour necrosis factor-α, interleukin-1β, and interleukin-6) and increased the anti-inflammatory cytokine interleukin-10. It also lowered serum aspartate aminotransferase and alanine aminotransferase activities, indicating reduced liver damage, and mitigated oxidative stress by decreasing malondialdehyde levels while restoring superoxide dismutase activity. Western blot analysis revealed that PLE inhibited the phosphorylation of NF-κB pathway proteins (p65 and IκB) and suppressed TLR4 expression, highlighting its role in this inflammatory pathway. Additionally, PLE ameliorated D-GalN/LPS-induced gut microbiota dysbiosis, reducing Proteobacteria abundance and promoting beneficial genera such as Lactobacillus, Bifidobacterium, and Akkermansia. These findings suggest that PLE protects against liver inflammation and oxidative stress, while improving gut microbiota composition, offering potential therapeutic strategies for liver-related diseases.
Determining the Impact of Adaptive Games on the Individuals’ Psycho-Emotional State among Different Age Groups in Poland and Ukraine
Authors: Skaliy Aleksander , Mulyk Viacheslav , Skaliy Tetiana , Maksymova Kateryna , Mulyk Kateryna 
Published: October 2024

Objectives. The study aimed to determine the effectiveness of implementating projects for the introduction of adaptive sports games on the psycho-emotional state of different population groups in Poland and Ukraine.
Materials and methods. A total of 341 individuals were involved in the study: 117 children (8-12 years old), 118 middle-aged people (35-60 years old), and 116 elderly people (60 years and older). The participants of the study were divided into two groups: those who took part in the Polish project “Academic Center of Sports and Health Games for Activation of People with Special Needs” (56 children, 65 adults, 73 elderly people), and those who took part in the Polish-Ukrainian project, which was conducted directly in Ukraine, “Ukrainian Center of Occupational Therapy through Adaptive Games” (61 children, 53 adults, 44 elderly people). All study participants were engaged in adaptive games (Cornhole, Jacollo, Elastik, Kulbutto, Boccia, Paka laka) for the first time. At the beginning and end of the event on adaptive games, a survey of participants was conducted. To determine the psycho-emotional state of children, the WAM method (well-being, activity, mood) was used, and the features of adults’ psychological state were assessed using the standard test AWAMW (anxiety, working capacity, activity, mood, well-being).
Results. The analysis of the obtained study results revealed positive changes in the psycho-emotional state of different population groups in Poland and Ukraine under the influence of adaptive sports games. Furthermore, the adult population, including the elderly of Poland and Ukraine, demonstrated decreased anxiety levels and a significant enhancement in activity, mood and well-being due to engaging in adaptive sports games.
Conclusions. This study emphasizes the potential of adaptive sports games to improve the mental health of different population groups. The findings also indicate the effectiveness of implementating projects for the introduction of adaptive games on the psycho-emotional state of different population groups both in Poland and Ukraine.
Contextos e Questões sobre EaD: um Estudo de Caso com um Estudante Cego
Authors: Marchiori Gustavo Silva , Lima Solange Cabral de , Nascimento Rayane Pereira do , Reis Clara Sabino , Rosario Miguel Longo Vieira Vidal do , Gomes Alícia Carrilho 
Published: October 2024

Este artigo consiste em um estudo de caso que trata de questões relativas à inclusão da pessoa com deficiência na educação a distância. Através de uma entrevista com um discente com deficiência visual desta modalidade de ensino, buscamos compreender aspectos significativos da relação entre educação a distância e a inclusão. Percebemos que a educação a distância tem potencial inclusivo para este discente desde sua origem, eliminando barreiras presentes na educação presencial. A evolução das tecnologias de informação e comunicação é outro fator que colabora para uma educação mais acessível. No entanto, percebe-se que ainda são necessárias melhorias gerais para uma educação inclusiva adequada.

Palavras-chave: Ensino superior. Educação a distância. Inclusão. Deficiência visual.
Cem Anos de Solidão: a Educação a Distância no Brasil – Percepções Negativas Antes e Depois da Pandemia
Authors: Viana Leonardo , Campos Milton N. , Álvarez Ibis M. , Proba Fabiane , Lo Bianco Vittório 
Published: October 2024

Com o centenário da educação a distância (EAD) no Brasil, completado em 2023, o artigo traz estudo exploratório descritivo de comparação das representações sociais negativas sobre a modalidade de ensino antes e depois da pandemia do coronavírus (2019 e 2023). O objetivo é refletir sobre a formação de um aparente preconceito em relação à EAD no país - de origem histórica, econômica e sociocultural - a partir da presente pesquisa do campo psicossocial, realizada com 1.000 candidatos do Vestibular Cederj – Centro de Educação Superior a Distância do Estado do Rio de Janeiro, nos referidos anos. A obra “Cem anos de solidão” de García Márquez inspira analogia sobre o “isolamento” da EAD, pelo pouco reconhecimento que parece ter marcado seus cem anos de existência. O percentual de participantes que apresentaram percepções negativas relacionadas à EAD esteve praticamente sem alteração nos períodos pré e pós-pandemia (42% em 2019 e 43% em 2023). Os dados foram coletados pela técnica de evocação de palavras inspirada em Abric, por meio de indagações ao ego (eu) e ao alter (outro). Amparados pela abordagem teórico-metodológica das Ágoras de Viana, analisamos os resultados com destaque para o fato de que as avaliações negativas sobressaíram significativamente em ambos os anos quando os pesquisados foram indagados a partir do alter e não do ego. O fato evidenciou que a construção do pensamento do indivíduo, influenciada pela sua condição de ser social, é fator preponderante para a formação das Ágoras: agrupamentos por afinidades de representações sociais.

Palavras-chave: Educação a distância. Representações sociais. Preconceito. Pandemia do coronavírus. Ágoras.
Analysis of Influence Factors on Line Shape of High-speed Railway Beam-Arch Combination Bridge
Authors: Chen Daihai , Xu Zhenqi , Qiu Yuanmiao 
Published: October 2024

Taking the prestressed continuous beam-arch composite bridge on the Zheng Wan High-speed Railway as a research object, which across the South-to-North Water Transfer in Zhang Liang Town, the space finite element model of the bridge was established by Midas/Civil, the cantilever casting construction process of the main beam was simulated, and the influence of many different parameters on beam line shape of the bridge was investigate. The results show that the unbalanced weight of the hanging basket and the prestressed steel bar parameters have less influence on the beam line shape; the bulk density of concrete and the arrangement length of counterweight have a great influence on line shape, therefore, these should be considered as key control parameters during construction, the counterweight of boom beam can reduce the deformation of bridge’s mid-span, it is advantageous for the Analysis of Influence Factors on Line Shape of High-speed Railway Beam-arch Combination Bridge line shape control of the bridge.
Influence of Surcharge Load on the Adjacent Pile Foundation in Coastal Floodplain
Authors: Zhang Hao , Sun Kai 
Published: October 2024

In this paper, in order to investigate the behavior of existing piles caused by the horizontal and compression deformation of soft substratum due to backfill surcharge on coastal floodplain, three-dimensional finite element models of piles adjacent to surcharge load were established. The deformation and migration law of soft soil was analyzed. The behavior of single pile and double row pile adjacent to surcharge load were studied, in which the influence of surcharge load location, surcharge pressure, pile stiffness, and pile top constraint conditions were considered. The results show that as the position of surcharge load is closer and the surcharge pressure increases, the response (e.g. deformation and bending moment) is more obvious. With the increase of pile stiffness, the range of passive load is increased. The deformation behavior of pile body under different constraints of pile cap is significantly different. The effect of secondary bending moment caused by pile axial force is obvious and cannot be ignored. If there is a thick soft substratum, it is beneficial to improve the behavior of adjacent piles by using cement mixing pile reinforcement.
Problems and Countermeasures of Double Row Pile Support Structure of Deep Foundation Pit in Geotechnical Engineering
Authors: Sun Yaqi 
Published: October 2024

With the development of geotechnical engineering, the double row pile support technology of deep foundation pit in geotechnical engineering has also been improved. However, at present, there are still problems, which affects the quality and safety of the whole geotechnical engineering, and requires measures to deal with them. This paper first describes the characteristics of double row pile support of deep foundation pit in geotechnical engineering, then analyzes the problems laying in it, and finally puts forward some countermeasures.
Accelerated reproduction of the parental lines of white cabbage using rosette plants (steckling) and artificial climate chambers
Authors: Bondareva L. L. , Mineykina A. I. 
Published: October 2024

Relevance. The technology of producing cabbage seeds with the traditional method takes almost 2 years. Its high labor intensity caused the need to search for cheaper methods of selection and seed production. One of the ways to speed up the stages of the selection process is the use of artificial climate chambers. The aim of research is to obtain seeds of promising inbred lines of late maturing white cabbage and hybrid combinations with their participation using rosette plants (steckling) in artificial climate chambers. Materials and Methods. The material was inbred pure lines of 5-6 generations of inbreeding, obtained from promising hybrid combinations of domestic and foreign breeding. The research was conducted in 2023-2024. Sowing in Plantek 64 cassettes was carried out on July 10, then the seedlings were transplanted into vegetative vessels with an optimal volume of 5-6 liters and installed in the open ground for the growth of a leaf outlet. In the phase 10-13 of real leaves, the plugs were placed in an artificial climate chamber. During the growth and development period, biometric and phenological observations were carried out, and an analysis of seed setting was carried out during the hybridization of inbred lines.Results. As a result of research in the study of hybrid seed production under artificial climate chamber conditions, high rates of seed setting in buds under cross-pollination of rosette plants of white cabbage were revealed. Genotypes with high seed set rate under geitenogamous bud pollination were also identified. The weight of 1000 seeds of the studied plants was within the range of 2.5-5.14 g. Genotypes 383-3, 384-2 and 384-7 were selected, which had the highest percentage of seeds in the fractional composition with size more than 2 mm 80.3%, 43.5% and 59.4%, respectively. When genotypes 384-2 and 384-7 were used in hybrid combinations as a maternal component, high quality indicators of the obtained seeds were revealed.Conclusion. For the studied genotypes of white cabbage, when grown in an artificial climate chamber, no significant effect on seed quality was found; the genotype had a greater effect on seed quality indicators.