bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tribulus terrestris Extract Improves Human Sperm Parameters In Vitro
Authors: Khaleghi Sara , Bakhtiari Mitra , Asadmobini Atefeh , Esmaeili Farzane 
Published: October 2016

Objective. The object of present study was to investigate the effects of direct addition of Tribulus terrestris extract on human sperm parameters. Design. Semen specimens from 40 healthy men volunteers were divided into 4 groups: one group received no treatment (control group) while the others were incubated with 20, 40, and 50 µg/mL of T terrestris extract (experimental groups). Motility, viability, and DNA fragmentation were assessed in all groups. Results. The incubation of human semen with 40 and 50 μg/mL of T terrestris extract significantly enhanced total sperm motility, number of progressive motile spermatozoa, and curvilinear velocity over 60 to 120 minutes’ holding time ( P < .05 or P < < .01). Furthermore, viability was significantly enhanced by using T terrestris extract ( P < .01). Conclusions. In vitro addition of the T terrestris extract to human sperm could affect male fertility capacity.
Polyphosphate colocalizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity
Authors: Mitchell Joanne L. , Lionikiene Ausra S. , Georgiev Georgi , Klemmer Anja , Brain Chelsea , Kim Paul Y. , Mutch Nicola J. 
Published: October 2016

Key PointsPolyP significantly augments the plasminogen activator capacity of FXIIa. Platelet-bound fibrin acts as a reservoir for plasminogen, FXII(a), and polyP.
Oviposition preferences for ethanol depend on spatial arrangement and differ dramatically among closely related Drosophila species
Authors: Sumethasorn Matt , Turner Thomas L. 
Published: October 2016

ABSTRACT
Recent work on the model fly Drosophila melanogaster has reported inconsistencies in their preference for laying eggs on intermediate concentrations of ethanol. In this study, we resolve this discrepancy by showing that this species strongly prefers ovipositing on ethanol when it is close to a non-ethanol substrate, but strongly avoids ethanol when options are farther apart. We also show fluidity of these behaviors among other Drosophila species: D. melanogaster is more responsive to ethanol than close relatives in that it prefers ethanol more than other species in the close-proximity case, but avoids ethanol more than other species in the distant case. In the close-proximity scenario, the more ethanol-tolerant species generally prefer ethanol more, with the exception of the island endemic D. santomea. This species has the lowest tolerance in the clade, but behaves like D. melanogaster. We speculate that this could be an adaptation to protect eggs from parasites or predators such as parasitoid wasps, as larvae migrate to non-toxic substrates after hatching. These natural differences among species are an excellent opportunity to study how genes and brains evolve to alter ethanol preferences, and provide an interesting model for genetic variation in preferences in other organisms, including humans.
Establishment of a novel retinoblastoma (Rb) nude mouse model by intravitreal injection of human Rb Y79 cells – comparison of in vivo analysis versus histological follow up
Authors: Tschulakow Alexander V. , Schraermeyer Ulrich , Rodemann H. Peter , Julien-Schraermeyer Sylvie 
Published: October 2016

ABSTRACT
Retinoblastoma (Rb) is the most frequent primary intraocular tumour in children and, if left untreated, can cause death. Preclinical animal models that mimic molecular, genetic, and cellular features of cancers are essential for studying cancer and searching for promising diagnosis and treatment modalities. There are several models described for Rb, but none of them fully meet our requirements. The aim of this study was to create a novel xenograft-nude mouse-model with broad application possibilities, which closely resembles the clinical observations of Rb patients and which could be used to investigate the development and spread of the tumour by using scanning laser ophthalmoscopy/optical coherence tomography (SLO/OCT) as well as histology methods. We injected human retinoblastoma Y79 cells intravitreally in both eyes of immune-deficient nude mice. The incidences of retinoblastoma as well as growth velocity were analysed 3, 6, 9 and 12 weeks after cell injection in vivo by SLO/OCT as well as ex vivo by electron microscopy (EM) and hematoxylin/eosin (HE) staining. Moreover, internal organs were histologically screened for potentially occurring metastases. Three weeks post-injection, animals developed a retinoblastoma, and after five weeks tumour growth resulted in swelling of the eyes in individual animals, showing a similar phenotype to that of untreated Rb patients at advanced stages of tumour-development. After 12 weeks, 67.5% of all analysed eyes (29 of 42) contained a retinoblastoma. At early stages of Rb development, the SLO/OCT analysis correlated with the histology results. If the tumours were too large, only histological investigations were feasible. The ultrastructural characteristics of the xenograft-tumours were very similar to those described for patient's tumours. In one mouse, brain metastases were observed. Our retinoblastoma mouse model closely resembles the human disease. SLO/OCT can be used for the detection of Rb at early stages of development and could be used for monitoring the success of future therapies.
Photoperiod induced obesity in the Brandt's vole (Lasiopodomys brandtii): a model of ‘healthy obesity’?
Authors: Liu Xin-Yu , Yang Deng-Bao , Xu Yan-Chao , Gronning Marianne O. L. , Zhang Fang , Wang De-Hua , Speakman John R. 
Published: October 2016

ABSTRACT
Brandt's voles have an annual cycle of body weight and adiposity. These changes can be induced in the laboratory by manipulation of photoperiod. In the present study, male captive-bred Brandt's voles aged 35 days were acclimated to a short day (SD) photoperiod (8L:16D) for 70 days. A subgroup of individuals (n=16) were implanted with transmitters to monitor physical activity and body temperature. They were then randomly allocated into long day (LD=16L:8D) (n=19, 8 with transmitters) and SD (n=18, 8 with transmitters) groups for an additional 70 days. We monitored aspects of energy balance, glucose and insulin tolerance (GTT and ITT), body composition and organ fat content after exposure to the different photoperiods. LD voles increased in weight for 35 days and then re-established stability at a higher level. At the end of the experiment LD-exposed voles had greater white adipose tissue mass than SD voles (P=0.003). During weight gain they did not differ in their food intake or digestive efficiency; however, daily energy expenditure was significantly reduced in the LD compared with SD animals (ANCOVA, P&lt;0.05) and there was a trend to reduced resting metabolic rate RMR (P=0.075). Physical activity levels were unchanged. Despite different levels of fat storage, the GTT and ITT responses of SD and LD voles were not significantly different, and these traits were not correlated to body fatness. Hence, the photoperiod-induced obesity was independent on disruptions to glucose homeostasis, indicating a potential adaptive decoupling of these states in evolutionary time. Fat content in both the liver and muscle showed no significant difference between LD and SD animals. How voles overcome the common negative aspects of fat storage might make them a useful model for understanding the phenomenon of ‘healthy obesity’.
Talin2-mediated traction force drives matrix degradation and cell invasion
Authors: Qi Lei , Jafari Naser , Li Xiang , Chen Zaozao , Li Liqing , Hytönen Vesa P. , Goult Benjamin T. , Zhan Chang-Guo , Huang Cai 
Published: October 2016

ABSTRACT
Talin binds to β-integrin tails to activate integrins, regulating cell migration, invasion and metastasis. There are two talin genes, TLN1 and TLN2, encoding talin1 and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function of talin2 is not clear and, indeed, talin2 has been presumed to function redundantly with talin1. Here, we show that talin2 has a much stronger binding to β-integrin tails than talin1. Replacement of talin2 Ser339 with Cys significantly decreased its binding to β1-integrin tails to a level comparable to that of talin1. Talin2 localizes at invadopodia and is indispensable for the generation of traction force and invadopodium-mediated matrix degradation. Ablation of talin2 suppressed traction force generation and invadopodia formation, which were restored by re-expressing talin2 but not talin1. Furthermore, re-expression of wild-type talin2 (but not talin2S339C) in talin2-depleted cells rescued development of traction force and invadopodia. These results suggest that a strong interaction of talin2 with integrins is required to generate traction, which in turn drives invadopodium-mediated matrix degradation, which is key to cancer cell invasion.
Ligand-induced growth and compaction of CD36 nanoclusters enriched in Fyn induces Fyn signaling
Authors: Githaka John Maringa , Vega Anthony R. , Baird Michelle A. , Davidson Michael W. , Jaqaman Khuloud , Touret Nicolas 
Published: October 2016

ABSTRACT
Nanoclustering is an emerging organizational principle for membrane-associated proteins. The functional consequences of nanoclustering for receptor signaling remain largely unknown. Here, we applied quantitative multi-channel high- and super-resolution imaging to analyze the endothelial cell surface receptor CD36, the clustering of which upon binding to multivalent ligands, such as the anti-angiogenic factor thrombospondin-1 (TSP-1), is thought to be crucial for signaling. We found that a substantial fraction of unligated CD36 exists in nanoclusters, which not only promote TSP-1 binding but are also enriched with the downstream effector Fyn. Exposure to multivalent ligands (TSP-1 or anti-CD36 IgM) that result in larger and denser CD36 clusters activates Fyn. Conversely, pharmacological perturbations that prevent the enhancement of CD36 clustering by TSP-1 abrogate Fyn activation. In both cases, there is no detectable change in Fyn enrichment at CD36 nanoclusters. These observations reveal a crucial role for the basal organization of a receptor into nanoclusters that are enriched with the signal-transducing downstream effectors of that receptor, such that enhancement of clustering by multivalent ligands is necessary and sufficient to activate the downstream effector without the need for its de novo recruitment.
Macroeconomic policy regime in Poland
Authors: Kazandziska Milka Kazandziska 
Published: October 2016

The goal of this paper is to analyse the economic development of Poland using the concept of macroeconomic policy regimes (MPRs). Six elements of a MPR will be identified: foreign economic policy, industrial policy, the financial system, wage policy, monetary policy and fiscal policy. Examining the functionality of the development of these elements applied to Poland is a further aim of this paper. The functionality of the development of the MPR elements will be analysed on the basis of the fulfilment of the objectives, as well as the use of the proposed instruments and strategy assigned to every element of MPR. Due to space limits, we are going to focus on the former in this paper. Taking into consideration that Poland is an emerging and a relatively open economy, foreign economic policy and industrial policy play very significant roles in restructuring of the economy towards production and exports of high value-added products, which would enable the country to follow a growth path consistent with an external balance. The financial needs of the manufacturing sector and particularly of the producers and/or exporters of high-end products need to be satisfied by the financial system, whose stability needs to be secured with the help of monetary policy. The latter is, moreover, in charge of providing low-cost finance and maintaining the stability of the exchange rate. Stabilising the inflation rate would be given to wage policy. Fiscal policy’s main tasks would be to correct aggregate demand shocks and reduce income inequality.
Economic sectors of strategic importance to the national security. A case of Poland
Authors: Lewandowski Remigiusz Lewandowski 
Published: October 2016

The purpose of the paper is to properly define the economic sectors of strategic importance to the national security and to evaluate the state’s tools which protect this security. The paper’s methodology is based on two analyses; the former focusing on instruments which are applied by the state in order to control certain fields of the economy, and the latter investigating economic sectors in terms of concentration, impact on the state security and integration with other sectors. The paper also defines the criteria which helped to identify sectors which have strategic importance to the national security, i.e. production and supply of electric energy; extraction and supply of natural gas; extraction, distribution and storage of liquid propellants, telecommunications, banking industry; banknotes and documents’ production (together with related IT solutions) and military industry. The article leads to the conclusion that these sectors are strategically important to the national security. However, there is still a lack of coherent and complete legal regulations that would protect the national security interest related to the part of the economy represented by the analyzed sectors and companies.
INSTRUMENTOS DE AVALIAÇÃO DA INCAPACIDADE E FUNCIONALIDADE DE TRABALHADORES COM DISTÚRBIOS MUSCULOESQUELÉTICOS RELACIONADOS AO TRABALHO: ANÁLISE DAS PROPOSTAS EXISTENTES
Authors: Magalhães Francesca Brito , Lima Mônica Angelim Gomes , Silva Ana Clarissa Lopes , Porto Lauro Antônio , Costa-Black Katia , Araújo Tânia Maria , Andrade Andrea Garboggini Melo , Carvalho Rita de Cássia Peralta , Neves Robson Fonseca 
Published: October 2016

Trata-se de uma revisão da literatura sobre instrumentos de avaliação de incapacidade e funcionalidade de trabalhadores com Distúrbios Musculoesqueléticos (DME) com vista ao retorno ao trabalho em uma perspectiva biopsicossocial. Abrange o período de dez anos, com levantamento bibliográfico nas bases de dados do Pubmed, Scopus, Psycoinfo, CINAHL, utilizando palavras-chaves relacionadas a protocolos de avaliação de incapacidade e funcionalidade para trabalhadores com DME. Apenas oito artigos abordavam o tema de interesse. Os artigos foram analisados nas dimensões biomédica, psicossocial e relacionada ao trabalho. Foram identificados 23 instrumentos para avaliação de incapacidade. Dentre os instrumentos com itens em mais de uma dimensão, foram encontrados seis que incorporaram as dimensões biomédica e psicossocial, três com itens de todas as dimensões e apenas um instrumento com itens das dimensões psicossocial e relacionada ao trabalho. Essa revisão mostra que são escassos os relatos sobre a existência e uso de instrumentos validados que tratem das dimensões biomédica, psicossocial e relacionada ao trabalho. Os instrumentos que utilizam uma abordagem compreensiva incluindo entrevista em profundidade e instrumentos validados podem ser um facilitador para o levantamento das demandas biopsicossociais do trabalhador doente.
Bounds for Bateman's G-function and its applications
Authors: Mahmoud Mansour , Agarwal Ravi P. 
Published: October 2016

Abstract
In this paper, we present an asymptotic formula for Bateman’s
G-function

G
⁢

(
x
)

${G(x)}$

and deduce the double inequality

1

2
⁢

x
2

+

3
/
2

<

G
⁢

(
x
)

-

1
x

<

1

2
⁢

x
2

,

x
>
0

.

$\frac{1}{2x^{2}+3/2}<G(x)-\frac{1}{x}<\frac{1}{2x^{2}},\quad x>0.$

We apply this result to find estimates for the error term of
the alternating series

∑

k
=
1

∞

(

-
1

)

k
-
1

k
+
h

$\sum_{k=1}^{\infty}\kern-2.0pt\frac{(-1)^{k-1}}{k+h}$

,

h
≠

-
1

,

-
2

,

-
3

,

…

$h\kern-1.0pt\neq\kern-1.0pt-1,\kern-0.5pt-2,\kern-0.5pt-3,\ldots\,$

.
Also, we study the monotonicity of some functions involving the function

G
⁢

(
x
)

${G(x)}$

. Finally, we propose
a sharp double inequality for the function

G
⁢

(
x
)

${G(x)}$

as a conjecture.
Gelatin as an ecofriendly natural polymer for preparing colloidal silver@gold nanobranches
Authors: Thi Phuong Phong Nguyen , Nguyen Dai Hai 
Published: October 2016

Abstract
We report star-shaped silver@gold (Ag@Au) nanoparticles (NPs) in gelatin suspensions for the purpose of enhancing the stability of Ag@Au NPs. In this case, Ag NPs were designed as nucleating agents, whereas gelatin was used as a protecting agent for Au development. Especially, variable gelatin concentrations were also prepared to explore its ability to increase the stability of Ag@Au NPs. The obtained samples were then characterized by UV-visible spectroscopy, transmission electron spectroscopy (TEM), X-ray diffraction, and Fourier transform infrared spectroscopy. The maximum absorption wavelength of all samples (566–580 nm) indicated that branched Ag@Au@gelatin NPs were successfully synthesized. In addition, our TEM results revealed that the size of branched Ag@Au@gelatin NPs was found to be between 20 and 45 nm as influenced by the component ratio and the pH value. These results can provide valuable insights into the improvement of Ag@Au NP stability in the presence of gelatin.
Crystal structure of 2-((3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-1H-indene-1,3(2H)-dione, C28H19N5O2
Authors: El-Hiti Gamal A. , Abdel-Wahab Bakr F. , Hegazy Amany S. , Alamri Mesfer , Kariuki Benson M. 
Published: October 2016

Abstract
C28H19N5O2, monoclinic, Cc (no. 9), a = 13.9896(9) Å, b = 21.9561(14) Å, c = 7.1643(5) Å, β = 91.782(6)°, V = 2199.5(3) Å3, Z = 4, R
gt(F) = 0.0632, wR
ref(F
2) = 0.1727, T = 150(2) K.
Crystal structure of 1-(adamantan-1-yl)-3-(3-chlorophenyl)thiourea, C17H21ClN2S
Authors: Al-Omary Fatmah A. M. , Al-Rasheed Lamees S. , Ghabbour Hazem A. , El-Emam Ali A. 
Published: October 2016

Abstract
C17H21ClN2S, orthorhombic, Pca21 (no. 29), a = 25.4796(11) Å, b = 6.7503(3) Å, c = 18.9971(9) Å, V = 3267.4(3) Å3, Z = 8, R
gt(F) = 0.045, wR
ref(F
2) = 0.106, T = 293(2).
Crystal structure of 8-isopropyl-8-aza-bicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate, C19H27NO3
Authors: Wang Kun-Yan , Yang Xiao-Li 
Published: October 2016

Abstract
C19H27NO3, monoclinic, P21/c (no. 14), a = 6.6207(3) Å, b = 9.4712(5) Å, c = 28.0365(14) Å, β = 94.716(2)°, V = 1752.10(15) Å3, Z = 4, R
gt(F) = 0.052, wR
ref(F
2) = 0.115, T = 296(2) K.
Crystal structure of dinuclear dichloridobis(dimethylformamide-kO)bis[μ2-3-(2-oxyphenyl)-5-(pyrazin-2-yl)-1,2,4-triazol-1ido-κ4-O,N:N′,N′′(2
−
)]diiron(III) − dimethylformamide (1/1), C36H42Cl2Fe2N14O6
Authors: Cao Xin , Sun Jianhua , Li Weihua , Lu Hui 
Published: October 2016

Abstract
C36H42Cl2Fe2N14O6, monoclinic, P21/c (no. 14), a = 10.44(4) Å, b = 9.13(3) Å, c = 22.46(7) Å, β = 100.88(4)°, V = 2101(12) Å3, Z = 2, R
gt(F) = 0.0599, wR
ref(F
2) = 0.1563, T = 296(2) K.
Crystal Structure of 4-(2-chloroacetamido)pyridinium chloride monohydrate, C7H10Cl2N2O2
Authors: Ghorab Mostafa M. , Alsaid Mansour S. , Ghabbour Hazem A. 
Published: October 2016

Abstract
C7H10Cl2N2O2, monoclinic, P21/c (no. 14), a = 9.8798(3) Å, b = 13.9285(5) Å, c = 7.3161(3) Å, β = 100.512(3)°, V = 989.88(6) Å3, Z = 4, R
gt
(F) = 0.0475, wR
ref
(F
2
) = 0.1178, T = 296 K.
Crystal structure of 2-amino-4-(4-chloro-phenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile, C16H13ClN2O2
Authors: Li Jingwei , Yang Jianxiang , Tao Qianqian , Yue Chenxi , He Jieli 
Published: October 2016

Abstract
C16H13ClN2O2, monoclinic, C2/c (no. 15), a = 13.7576(10) Å, b = 11.0534(5) Å, c = 19.6232(14) Å, β = 107.776(8)°, V = 2841.6(3) Å3, Z = 8, R
gt(F) = 0.0407, wR
ref(F
2) = 0.1105, T = 293(2) K.
Evaluation of low-template DNA profiles using peak heights
Authors: Steele Christopher D. , Greenhalgh Matthew , Balding David J. 
Published: October 2016

Abstract
In recent years statistical models for the analysis of complex (low-template and/or mixed) DNA profiles have moved from using only presence/absence information about allelic peaks in an electropherogram, to quantitative use of peak heights. This is challenging because peak heights are very variable and affected by a number of factors. We present a new peak-height model with important novel features, including over- and double-stutter, and a new approach to dropin. Our model is incorporated in open-source R code likeLTD. We apply it to 108 laboratory-generated crime-scene profiles and demonstrate techniques of model validation that are novel in the field. We use the results to explore the benefits of modeling peak heights, finding that it is not always advantageous, and to assess the merits of pre-extraction replication. We also introduce an approximation that can reduce computational complexity when there are multiple low-level contributors who are not of interest to the investigation, and we present a simple approximate adjustment for linkage between loci, making it possible to accommodate linkage when evaluating complex DNA profiles.
Inline imaging-ellipsometer for printed electronics
Authors: Huemer Florian , Jamalieh Murad , Bammer Ferdinand , Hönig Dirk 
Published: October 2016

Abstract
Printed electronics, e.g. organic photo-voltaic, are usually produced
by roll-to-roll printing. For this fast growing market no
inline-measurement method for 2D-thickness-distributions after
printing exists. In many cases layer-thicknesses are in the
sub-μm-range, e.g. 10–300 nm, and ellipsometry is one typical
technology for this range, but up to now only in the laboratory, since
most ellipsometers are too slow and/or measure only a spot. A new
concept, a stroboscopic imaging ellipsometer, enables fast measurement
on a line, to acquire the 2D-distribution of thickness, right after
printing.
Investigating dynamic measurement applications through modelling and simulation
Authors: Esward Trevor J. 
Published: October 2016

Abstract
Dynamic measurement challenges are ubiquitous in metrology and can be found in many
measurement applications that are not conventionally regarded as dynamic. We present four
recent examples of work at the UK's National Physical Laboratory that demonstrate how
modelling and simulation can contribute to improved understanding of dynamic measurement
tasks. The examples are (i) a software simulation of a lock-in amplifier, (ii) a simulation
of a sensor network in which one of the sensors has insufficient bandwidth for the
measurement task and Kalman filter based data fusion is used to aggregate the sensor
outputs, (iii) a study of performance imperfections in a clock embedded in a wireless sensor
node using a Monte Carlo based method for simulating counting errors, and (iv) a simulation
of wave propagation in a shock tube in which the lattice Boltzmann method was used to study
non-ideal behaviour of the shock tube. It is shown that simulation (both physically based
and phenomenological) is useful in designing measuring systems and identifying and
quantifying measurement uncertainties and that the development of simulation software
requires the developer to have a clear understanding of the measuring system of interest.
In-Line Ultraschall-Messung von Strömungsprofilen wandgleitender Kunststoffe während der Extrusion
Authors: Putz Veronika , Apostol Sylvia , Selvasankar Ramesh K. , Voglhuber-Brunnmaier Thomas , Miethlinger Jürgen , Zagar Bernhard G. , Buchegger Thomas 
Published: October 2016

Zusammenfassung
Zur Modellierung des Strömungsverhaltens von Kunststoffschmelzen und zur Auslegung des verwendeten Extrusionswerkzeugs
muss das Strömungsprofil des Polymers unter Prozessbedingungen bekannt sein. Von besonderem Interesse dabei ist, ob
sogenanntes Wandgleiten auftritt oder nicht. Mit Hilfe der Pulsed-Wave Sonografie kann das Strömungsprofil in
transparenten und opaken Flüssigkeiten gemessen werden. Dieser Beitrag zeigt, wie damit unter Verwendung eines Clamp-In
Waveguides, der in das Extrusionswerkzeug integriert wurde, Strömungsprofile in-line während der Extrusion gemessen werden
können. Messergebnisse, die bei der Extrusion von wandgleitenden Polylactiden (PLA) bei unterschiedlichen
Kanaltiefen erhalten wurden, werden gezeigt.