bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whither the Funnel of Causality?
Authors: Wilder Matt 
Published: January 2017

AbstractIf Richard Simeon's “Studying Public Policy” sought to inspire a theory of policy making, however tentative or crude, its conceptual cornerstone was no doubt the “funnel of causality.” Yet references to the funnel of causality have all but disappeared from the policy literature. This article traces the evolution of the thinking that underlies the funnel of causality with the aim of demonstrating its lasting relevance to policy studies. Being a method for understanding how inputs from various levels of abstraction impact policy outcomes, the interaction and feedback effects implicit in the funnel metaphor have been maintained in subsequent neo-institutionalist work that takes seriously the institutional and sociological environment in which policy making takes place, particularly that which is interested in the origins and operation of policy subsystems, policy communities or networks, and policy regimes.
The Lawyer Who Mocked Hitler, and Other Jewish Commentaries on the Nuremberg Laws
Authors: Morris Douglas G. 
Published: January 2017

AbstractNazi Germany’s Nuremberg Laws of 1935 generated legal commentary by Nazi jurists who eagerly extended its antisemitic principles—but not by Jewish lawyers, for whom the discrimination was too blatant and the risks of public criticism too dangerous. In the winter of 1936-37 in Leipzig, however, one obscure lawyer named Max Hellmann made an incisive commentary about the laws. Faced with prosecution for employing a female “Aryan” cook, Hellmann, a convert and widower in despair, responded boldly: he subpoenaed Adolf Hitler to testify and even moved to imprison him pending the judge’s decision. His defense was, in fact, a satire. It mocked the so-called Führerprinzip (leadership principle), i.e., the idea of law as the Führer’s will, at the heart of the Nazi legal system. Persistently contrasting the need for legal procedures with the primacy of irrational will, Hellmann showed that the leadership principle was incoherent with regard to the separation of powers, the role of the judiciary, the process of legislation, and the very nature of law itself. He provided a detailed critique of Nazi law that insiders, such as Nazi jurists, dared not think, and that outsiders, such as Jewish lawyers, had no reason to develop.
Effect of the patient-to-patient communication model on dysphagia caused by total laryngectomy
Authors: Tian L , An R , Zhang J , Sun Y , Zhao R , Liu M 
Published: January 2017

AbstractObjective:The study aimed to evaluate the effect of a patient-to-patient communication model on dysphagia in laryngeal cancer patients after total laryngectomy.Methods:Sixty-five patients who had undergone total laryngectomy were randomly divided into three groups: a routine communication group, a patient communication group (that received the patient-to-patient communication model) and a physician communication group. Questionnaires were used to compare quality of life and swallowing problems among all patient groups.Results:The main factors causing dysphagia in total laryngectomy patients were related to fear and mental health. The patient communication group had improved visual analogue scale scores at one week after starting to eat. Quality of life in swallowing disorders questionnaire scores were significantly higher in the patient communication and physician communication groups than in the routine communication group. In addition, swallowing problems were much more severe in patients educated to high school level and above than in others.Conclusion:The patient-to-patient communication model can be used to resolve swallowing problems caused by psychological factors in total laryngectomy patients.
One hundred years of external approach medialisation thyroplasty
Authors: Crolley V E , Gibbins N 
Published: January 2017

AbstractIt has been 100 years since Erwin Payr first developed an operation to improve the effects of a paralysed vocal fold, and operations based on this technique are still in use today. This technique, medialisation thyroplasty, aims to improve the symptoms caused by vocal fold palsy by realigning the lateralised vocal fold into the midline.Whilst the effects of vocal fold palsy were recognised in antiquity, it was only with the development of indirect laryngoscopy in the late nineteenth century that the vocal fold paralysis could be identified as an aetiology for poor phonation and dysphagia. Payr, in 1915, was the first to perform a recognisable form of medialisation thyroplasty, which was further developed in the early twentieth century, but medialisation thyroplasty did not begin to be widely used until the development of the modern technique by Isshikiet al., in 1974.Since then, medialisation thyroplasty has continued to be developed and is currently the most widely used technique for correcting the effects of vocal fold palsy. However, a wide array of therapeutic options is now available for vocal fold palsy and it is impossible to say whether or not medialisation thyroplasty will still be used in another 100 years.
Safe balloon sizing for endoscopic dilatation of subglottic stenosis in children
Authors: Sharma S D , Gupta S L , Wyatt M , Albert D , Hartley B 
Published: January 2017

AbstractObjectives:To describe our experience and provide guidelines for maximum safe balloon sizes according to age in children undergoing balloon dilatation.Method:A retrospective review was conducted of children undergoing balloon dilatation for subglottic stenosis in a paediatric tertiary unit between May 2006 and February 2016.Results:A total of 166 patients underwent balloon dilatation. Mean ( ± standard deviation) patient age was 4.5 ± 3.99 years. The median balloon size was 8 mm, the median balloon inflation pressure was 10 atm, and the mean balloon inflation time was 65.1 ± 18.6 seconds. No significant unexpected events occurred. The Pearson correlation co-efficient for the relationship between patient age and balloon size was 0.85 (p = 0.001), suggesting a strongly positive correlation.Conclusion:This study demonstrated that balloon dilatation is a safe procedure for airway stenosis. The results suggest using a balloon diameter that is equal to the outer diameter of the age-appropriate endotracheal tube +1 mm for the larynx and subglottis and +2 mm for the trachea.
Capronia suijae(Herpotrichiellaceae, Eurotiomycetes), a new fungus onXanthoria parietinafrom Belarus, with a key to the lichenicolous species growing onXanthorias. str.
Authors: TSURYKAU Andrei , ETAYO Javier 
Published: January 2017

AbstractThe new lichenicolous fungusCapronia suijaegrowing on the thallus of corticolousXanthoria parietinais described from Belarus and compared with similar species. In addition to its host selection, the species is characterized by comparatively small ascomata, 40–80 μm diam., and (0–1–)3-septate ascospores, 9·5–11·5×4·0–5·0 μm. A key to the lichenicolous fungi growing onXanthorias. str. is provided.
Platythecium seychellense, a new species in the family Graphidaceae (lichenized Ascomycota: Ostropales) from the Seychelles and a world key to the genus
Authors: NEUWIRTH Gerhard , APTROOT André , STOCKER-WÖRGÖTTER Elfie 
Published: January 2017

AbstractThe new corticolous lichen fungus Platythecium seychellense is described from the Seychelles. Morphological characters as well as distribution and resemblance to related species are discussed. The species is characterized by a crustose, grey-green, smooth thallus lacking lichen substances, elongate and slender apothecia having flat, red-brown discs and grey 3-septate ascospores. A world key to all currently known species in the genus is presented.
Insights into the genus Austrella (Pannariaceae, Peltigerales), including a new species from the Falkland Islands
Authors: FRYDAY Alan M. , ERTZ Damien , JØRGENSEN Per Magnus 
Published: January 2017

AbstractThe new species Austrella isidioidea, which is unique in the genus in having isidioid structures on the thallus lobe ends as well as apothecia lacking a thalline margin, is described from the Falkland Islands. A collection with an identical mtSSU rDNA sequence to A. arachnoidea but with significant morphological differences (viz. a variable apothecial margin ranging from an arachnoid hyphal weft to a corticated regular margin) is reported from Îles Kerguelen. The phylogenetic and biogeographical implications of these new records are discussed.
Epidemiology of parainfluenza infection in England and Wales, 1998–2013: any evidence of change?
Authors: ZHAO H. , HARRIS R. J. , ELLIS J. , DONATI M. , PEBODY R. G. 
Published: January 2017

SUMMARYHuman parainfluenza virus (HPIV) infections are one of the commonest causes of upper and lower respiratory tract infections. In order to determine if there have been any recent changes in HPIV epidemiology in England and Wales, laboratory surveillance data between 1998 and 2013 were analysed. The UK national laboratory surveillance database, LabBase, and the newly established laboratory-based virological surveillance system, the Respiratory DataMart System (RDMS), were used. Descriptive analysis was performed to examine the distribution of cases by year, age, sex and serotype, and to examine the overall temporal trend using the χ2 test. A random-effects model was also employed to model the number of cases. Sixty-eight per cent of all HPIV detections were due to HPIV type 3 (HPIV-3). HPIV-3 infections were detected all year round but peaked annually between March and June. HPIV-1 and HPIV-2 circulated at lower levels accounting for 20% and 8%, respectively, peaking during the last quarter of the year with a biennial cycle. HPIV-4 was detected in smaller numbers, accounting for only 4% and also mainly observed in the last quarter of the year. However, in recent years, HPIV-4 detection has been reported much more commonly with an increase from 0% in 1998 to 3·7% in 2013. Although an overall higher proportion of HPIV infection was reported in infants (43·0%), a long-term decreasing trend in proportion in infants was observed. An increase was also observed in older age groups. Continuous surveillance will be important in tracking any future changes.
How expensive is a cardioprotective diet? Analysis from the CRESSIDA study
Authors: Reidlinger Dianne P , Sanders Thomas AB , Goff Louise M 
Published: January 2017

AbstractObjectiveTo determine whether a cardioprotective dietary intervention based on UK dietary guidelines was more expensive than a conventional UK diet.DesignCost analysis of food records collected at baseline and after a 12-week dietary intervention of a cardioprotective diet v. conventional UK diet.SettingA randomized controlled dietary intervention study (CRESSIDA; ISRCTN 92382106) investigating the impact of following a diet consistent with UK dietary guidelines on CVD risk.SubjectsParticipants were healthy UK residents aged 40–70 years. A sub-sample of participants was randomly selected from those who completed the cardioprotective dietary intervention (n 20) or the conventional UK dietary intervention (n 20).ResultsBaseline diet costs did not differ between groups; mean daily food cost for all participants was £6·12 (sd £1·83). The intervention diets were not more expensive: at end point the mean daily cost of the cardioprotective diet was £6·43 (sd £2·05) v. the control diet which was £6·53 (sd £1·53; P=0·86).ConclusionsThere was no evidence that consumption of a cardioprotective diet was more expensive than a conventional dietary pattern. Despite the perception that healthier foods are less affordable, these results suggest that cost may not be a barrier when modifying habitual intake and under tightly controlled trial conditions. The identification of specific food groups that may be a cost concern for individuals may be useful for tailoring interventions for CVD prevention for individuals and populations.
Implementing and integrating a radiation oncology information system as a pedagogical tool for undergraduate radiation therapy training
Authors: Chamunyonga Crispen , Rutledge Peta , Caldwell Peter , Burbery Julie 
Published: January 2017

AbstractPurposeRadiation oncology information systems (OIS) play a crucial role in radiation therapy by ensuring accurate and safe delivery of treatment. A MOSAIQ OIS system is currently used to support undergraduate radiation therapist training at Queensland University of Technology. This review addresses the rationale for implementation and integration in teaching environments and explores the pedagogical benefits supported by educational theory.DiscussionA review of MOSAIQ functionality shows potential to transform learning through the development of authentic and engaging learning tasks. It provides students with an opportunity to learn two-dimensional image matching through the use of digitally reconstructed radiographs and electronic portal images as well as three-dimensional image matching using computed tomography (CBCT) data in a safe learning environment without clinical time pressures. In addition, this provides the students with knowledge of quality assurance (QA) checks through the verification of treatment parameters and the transfer of information from the planning system to the treatment units. However, there are several potential challenges and practical considerations that need to be overcome.ConclusionThe application of MOSAIQ OIS could potentially transform teaching and learning strategies for student radiation therapists. Increased knowledge and hands-on skills at undergraduate levels in areas such as image matching and QA can be powerful tools to drive the standards of practice a step further.
Effect of LINAC-based postoperative radiotherapy on local control and survival in patients with non-small cell lung cancer
Authors: Cecen Sare , Yavuz Ali A. , Cecen Yigit , Duman Evrim , Ozdemir Beyza S. , Aksu Melek G. 
Published: January 2017

AbstractAimTo perform a retrospective analysis of survival, local–regional control and the effect of prognostic factors in 61 non-small cell lung cancer patients who were treated with postoperative radiotherapy (PORT) by a linear accelerator (LINAC).Material and methodsA total of 50–66 Gy PORT with a fractional dose of 1·8–2 Gy was administered to 24 patients (24·5%) for surgical margin positivity, 33 patients (54%) for mediastinal lymph node involvement and 13 patients (21·5%) for both mediastinal lymph node involvement and positive surgical margins.ResultsMedian follow-up was 17 months, and the median survival and median distant metastasis-free survival were 25 and 19 months, respectively. Local-regional progression was observed in 10 patients (16·4%). Treatment modality (2D/3D) (p=0·021), tumour size >4 cm (p=0·004), surgical margin positivity (p=0·001), and left lung localisation of the tumour (p≤0·05) were the prognostic factors in terms of survival.ConclusionsA survey of the literature shows that, without PORT, local recurrence or progression rates increase while overall survival rates decrease. In this study, only patients with PORT are studied and the results show that the local progression and overall survival rates are comparable with literature of LINAC-based PORT. In the case of overall survival, 3D treatment shows better results than 2D treatment modality.
Preparation for the end of life and life completion during late-stage lung cancer: An exploratory analysis
Authors: Adorno Gail , Wallace Cara 
Published: January 2017

ABSTRACTObjective:Our aim was to explore preparation for the end of life (EoL) and life closure among persons with advanced metastatic lung cancer. Understanding quality of life through the lens of preparation and completion is important since the trajectory of lung cancer can be relatively short, often leading to application of cancer-directed therapies near death without the opportunity for advance planning or palliative care. Clinical research is needed to understand the kinds of distress specific to older adults with advanced lung cancer that are amendable to palliative care interventions.Method:We employed an exploratory cross-sectional design to examine psychosocial and existential concerns among a purposive sample (N = 30) of advanced lung cancer patients using the “end-of-life preparation” and “life completion” subscales of the Quality of Life at the End of Life (QUAL–E) questionnaire. Nonparametric methods were employed to analyze preparation, completion, global quality of life (QoL), and the associations among depressive symptoms, preparation, completion, and global QoL.Results:Higher scores on life completion were associated with better global QoL, and with items related to transcendence, communicative acts, and interpersonal relationships demonstrating important contributions. The perception of being a future burden on family members was the greatest concern within the preparation domain. Depressive symptoms were not associated with preparation, completion, or global QoL.Significance of Results:Psychosocial and existential issues contribute to QoL at the EoL among older adults with late-stage lung cancer during cancer-directed therapy, concurrent care, and hospice. The role of preparation, especially self-perceived burden, merits further research early on in the oncological setting. The preparation and life completion subscales of the QUAL–E are feasible clinical tools for facilitating dyadic communication about sensitive topics in the palliative care setting.
Enhancing Selective Exposure to Health Messages and Health	Intentions
Authors: Hastall Matthias R. , Wagner Anna J. M. 
Published: January 2017

Abstract. Insufficient message exposure is still a major obstacle for effective health communication activities, and little is known on how message features affect selective exposure and persuasion. This study examined the effects of two health message features, suggested susceptibility and gain–loss framing, on respondents’ selective exposure and subsequent health behavior intentions. Two personality traits, repression-sensitization and approach/avoidance motivation, were studied as moderators of the proposed relationships. An experimental 2 (suggested susceptibility: low vs. high) × 2 (gain–loss framing: gain- vs. loss-framed message) study was conducted. Participants browsed through an online health magazine while their message choices were unobtrusively logged. A subsequent online questionnaire assessed personality dispositions and behavioral intentions. High levels of message susceptibility increased both selective exposure to health messages and respondents’ motivation to engage in adaptive health behaviors. Gain–loss framing did not affect message exposure or behavioral intentions, with one exception: Avoidance-oriented low-anxious respondents selected more loss-framed than gain-framed articles for reading. Repression-sensitization and approach/avoidance motivation did not moderate health message effects, but partly influenced these measures directly or in combination. The number of articles to choose from was limited, and it is unclear to what extent the findings can be generalized to other, more familiar health topics. Emphasizing readers’ susceptibility to health threats appears very effective for increasing exposure to health messages and protective behavioral intentions. The effectiveness of gain–loss framing, by contrast, largely depends on moderating factors.
MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
Authors: Krishnan Keerthi , Lau Billy Y. B. , Ewall Gabrielle , Huang Z. Josh , Shea Stephen D. 
Published: January 2017

AbstractNeurodevelopmental disorders are marked by inappropriate synaptic connectivity early in life, but how disruption of experience-dependent plasticity contributes to cognitive and behavioural decline in adulthood is unclear. Here we show that pup gathering behaviour and associated auditory cortical plasticity are impaired in female Mecp2het mice, a model of Rett syndrome. In response to learned maternal experience, Mecp2het females exhibited transient changes to cortical inhibitory networks typically associated with limited plasticity. Averting these changes in Mecp2het through genetic or pharmacological manipulations targeting the GABAergic network restored gathering behaviour. We propose that pup gathering learning triggers a transient epoch of inhibitory plasticity in auditory cortex that is dysregulated in Mecp2het. In this window of heightened sensitivity to sensory and social cues, Mecp2 mutations suppress adult plasticity independently from their effects on early development.
Sixfold improved single particle measurement of the magnetic moment of the antiproton
Authors: Nagahama H. , Smorra C. , Sellner S. , Harrington J. , Higuchi T. , Borchert M. J. , Tanaka T. , Besirli M. , Mooser A. , Schneider G. , Blaum K. , Matsuda Y. , Ospelkaus C. , Quint W. , Walz J. , Yamazaki Y. , Ulmer S. 
Published: January 2017

AbstractOur current understanding of the Universe comes, among others, from particle physics and cosmology. In particle physics an almost perfect symmetry between matter and antimatter exists. On cosmological scales, however, a striking matter/antimatter imbalance is observed. This contradiction inspires comparisons of the fundamental properties of particles and antiparticles with high precision. Here we report on a measurement of the g-factor of the antiproton with a fractional precision of 0.8 parts per million at 95% confidence level. Our value "Equation missing"/2=2.7928465(23) outperforms the previous best measurement by a factor of 6. The result is consistent with our proton g-factor measurement gp/2=2.792847350(9), and therefore agrees with the fundamental charge, parity, time (CPT) invariance of the Standard Model of particle physics. Additionally, our result improves coefficients of the standard model extension which discusses the sensitivity of experiments with respect to CPT violation by up to a factor of 20.
SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
Authors: Luo Lin , Bokil Nilesh J. , Wall Adam A. , Kapetanovic Ronan , Lansdaal Natalie M. , Marceline Faustine , Burgess Belinda J. , Tong Samuel J. , Guo Zhong , Alexandrov Kirill , Ross Ian L. , Hibbs Margaret L. , Stow Jennifer L. , Sweet Matthew J. 
Published: January 2017

AbstractDanger signals activate Toll-like receptors (TLRs), thereby initiating inflammatory responses. Canonical TLR signalling, via Toll/Interleukin-1 receptor domain (TIR)-containing adaptors and proinflammatory transcription factors such as NF-κB, occurs in many cell types; however, additional mechanisms are required for specificity of inflammatory responses in innate immune cells. Here we show that SCIMP, an immune-restricted, transmembrane adaptor protein (TRAP), promotes selective proinflammatory cytokine responses by direct modulation of TLR4. SCIMP is a non-TIR-containing adaptor, binding directly to the TLR4-TIR domain in response to lipopolysaccharide. In macrophages, SCIMP is constitutively associated with the Lyn tyrosine kinase, is required for tyrosine phosphorylation of TLR4, and facilitates TLR-inducible production of the proinflammatory cytokines IL-6 and IL-12p40. Point mutations in SCIMP abrogating TLR4 binding also prevent SCIMP-mediated cytokine production. SCIMP is, therefore, an immune-specific TLR adaptor that shapes host defence and inflammation.