bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement properties of tools used to assess depression in adults with and without autism spectrum conditions: A systematic review
Authors: Cassidy S. A. , Bradley L. , Bowen E. , Wigham S. , Rodgers J. 
Published: January 2018

Depression is the most commonly experienced mental health condition in adults with autism spectrum conditions (ASC). However, it is unclear what tools are currently being used to assess depression in ASC, or whether tools need to be adapted for this group. This systematic review therefore aimed to identify tools used to assess depression in adults with and without ASC, and then evaluate these tools for their appropriateness and measurement properties. Medline, PsychINFO and Web of Knowledge were searched for studies of depression in: (a) adults with ASC, without co‐morbid intellectual disability; and (b) adults from the general population without co‐morbid conditions. Articles examining the measurement properties of these tools were then searched for using a methodological filter in PubMed, and the quality of the evidence was evaluated using the COSMIN checklist. Twelve articles were identified which utilized three tools to assess depression in adults with ASC, but only one article which assessed the measurement properties of one of these tools was identified and thus evaluated. Sixty‐four articles were identified which utilized five tools to assess depression in general population adults, and fourteen articles had assessed the measurement properties of these tools. Overall, two tools were found to be robust in their measurement properties in the general population—the Beck Depression Inventory (BDI‐II), and the patient health questionnaire (PHQ‐9). Crucially only one study was identified from the COSMIN search, which showed weak evidence in support of the measurement properties of the BDI‐II in an ASC sample. Implications for effective measurement of depression in ASC are discussed. Autism Res 2018, 11: 738–754. © 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc.Lay SummaryDepression is the most common mental health problem experienced by adults with autism. However, the current study found very limited evidence regarding how useful tools developed for the general population are for adults with autism. We therefore suggest how these tools could be adapted to more effectively assess depression in adults with autism, and improve these individuals access to mental health assessment and support.
Diminished respiratory sinus arrhythmia response in infants later diagnosed with autism spectrum disorder
Authors: McCormick Carolyn E.B. , Sheinkopf Stephen J. , Levine Todd P. , LaGasse Linda L. , Tronick Ed , Lester Barry L. 
Published: January 2018

Indicators of risk for developing Autism Spectrum Disorder (ASD) are difficult to detect within the first year of life. In this study, infants who were originally followed prospectively to examine general developmental risks due to substance exposure interacted with their mother and an unfamiliar experimenter for 2‐min episodes at 4 months of age. Electrocardiogram was collected to measure respiratory sinus arrhythmia (RSA) and the session was video recorded for behavioral coding. Two groups of infants were compared: infants with a diagnosed ASD outcome (N = 8) and matched controls (N = 186). Infants were compared on mean RSA and infant behavioral codes for each 2‐min episode. No significant group differences were revealed on RSA or behavior during interactions between the infants and mothers. However, in response to play with a stranger, infants with an ASD outcome had lower RSA (M = 2.49, 95% CI [2.30, 2.98]) than controls (M = 3.12, 95% CI [3.06, 3.18]). During the interaction with a stranger, lower RSA response was associated with more protesting behaviors (P < 0.01), whereas higher RSA response was associated with more social monitoring (P = 0.001). Lower RSA suggests that 4‐month‐old infants later diagnosed with ASD exhibited poorer autonomic regulation during interaction with an unfamiliar adult than did controls. Physiological regulation during interactions with a new social partner may be disrupted early in infancy in children with ASD, as indicated here by lower RSA, and therefore be a potential target for developing early risk screening tools for ASD. Autism Res 2018, 11: 726–731. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryAutism Spectrum Disorder (ASD) emerges within the first years of life; however, it is difficult to identify children who will develop autism before 12 months of age based on behavioral measures. In a study of infants who were followed from birth, infants who were later diagnosed with ASD had poorer physiological regulation during play with a new adult. With additional evidence, poorer physiological regulation may function as an early sign of ASD risk.
Combat biofilm by bacteriostatic aptamer‐functionalized graphene oxide
Authors: Mao Biyao , Cheng Lijuan , Wang Sheng , Zhou Jiaqi , Deng Le 
Published: January 2018

AbstractBiofilms are the main reason for a large number deaths and high health costs. Their better protection compared to planktonic form against conventional antibiotics leads to poor treatment efficiency. Nanoagent‐targeted delivery is a promising avenue for disease therapeutic, but its application targeting biofilms has not been reported currently. The roles, if any, of aptamers acting as delivery carrier and targeting factor, the graphene oxide (GO), and GO modified with aptamers against biofilms were then systematically evaluated. Here, we successfully developed an aptamer‐targeted GO strategy against biofilms. We investigated the efficacy of aptamer–GO conjugates by UV spectrophotometer, inverted microscopy, and atomic force microscopy; 93.5 ± 3.4% Salmonella typhimurium biofilms were inhibited and 84.6 ± 5.1% of biofilms were dispersed by a ST‐3‐GO conjugate. More importantly, this conjugate represented distinctively toxicity to S. typhimurium. Thus, this strategy significantly displays excellent antibiofilm properties and may serve as a long‐term solution for biofilm control.
Understanding ‘Unlikely (20% Likelihood)’ or ‘20% Likelihood (Unlikely)’ Outcomes: The Robustness of the Extremity Effect
Authors: Jenkins Sarah C. , Harris Adam J.L. , Lark R.M. 
Published: January 2018

AbstractCalls to communicate uncertainty using mixed, verbal‐numerical formats (‘unlikely [0–33%]’) have stemmed from research comparing mixed with solely verbal communications. Research using the new ‘which outcome’ approach to investigate understanding of verbal probability expressions suggests, however, that mixed formats might convey disadvantages compared with purely numerical communications. When asked to indicate an outcome that is ‘unlikely’, participants have been shown to often indicate outcomes with a value exceeding the maximum value shown, equivalent to a 0% probability —an ‘extremity effect’. Recognising the potential consequences of communication recipients expecting an ‘unlikely’ event to never occur, we extend the ‘which outcome’ work across four experiments, using verbal, numerical, and verbal‐numerical communication formats, as well as a previously unconsidered numerical‐verbal format. We examine how robust the effect is in the context of consequential outcomes and over non‐normal distributions. We also investigate whether participants are aware of the inconsistency in their responses from a traditional ‘how likely’ and ‘which outcome’ task. We replicate and extend previous findings, with preference for extreme outcomes (including above maximum values) observed in both verbal and verbal‐numerical formats. Our results suggest caution in blanket usage of recently recommended verbal‐numerical formats for the communication of uncertainty. Copyright © 2018 John Wiley & Sons, Ltd.
Glutamine synthetase gene knockout‐human embryonic kidney 293E cells for stable production of monoclonal antibodies
Authors: Yu Da Young , Lee Sang Yoon , Lee Gyun Min 
Published: January 2018

AbstractPreviously, it was inferred that a high glutamine synthetase (GS) activity in human embryonic kidney (HEK) 293E cells results in elevated resistance to methionine sulfoximine (MSX) and consequently hampers GS‐mediated gene amplification and selection by MSX. To overcome this MSX resistance in HEK293E cells, a GS‐knockout HEK293E cell line was generated using the CRISPR/Cas9 system to target the endogenous human GS gene. The GS‐knockout in the HEK293E cell line (RK8) was confirmed by Western blot analysis of GS and by observation of glutamine‐dependent growth. Unlike the wild type HEK293E cells, the RK8 cells were successfully used as host cells to generate a recombinant HEK293E cell line (rHEK293E) producing a monoclonal antibody (mAb). When the RK8 cells were transfected with the GS expression vector containing the mAb gene, rHEK293E cells producing the mAb could be selected in the absence as well as in the presence of MSX. The gene copies and mRNA expression levels of the mAb in rHEK293E cells were also quantified using qRT‐PCR. Taken together, the GS‐knockout HEK293E cell line can be used as host cells to generate stable rHEK293E cells producing a mAb through GS‐mediated gene selection in the absence as well as in the presence of MSX.
Adoption of the transradial approach for percutaneous coronary intervention and rates of vascular complications following transfemoral procedures: Insights from NCDR
Authors: Badri Marwan , Shapiro Timothy , Wang Yongfei , Minges Karl E. , Curtis Jeptha P. , Gray William A. 
Published: January 2018

AbstractObjectivesThis study was designed to examine the association between adopting the transradial approach for percutaneous coronary intervention (PCI) and rates of vascular complications following transfemoral PCI.BackgroundRecent studies raised concerns that operators adopting the transradial approach may lose their transfemoral access skills and experience increased rates of vascular complications.MethodsRetrospective analysis of data from the NCDR CathPCI Registry to examine the rates of vascular complications among physicians who were femoral operators (>90% of cases) in 2010–2011 and later adopted the transradial approach to PCI among low‐, intermediate‐, or high‐level adopters (≤33%, 34–66%, and >66%, respectively) in 2014–2015. Propensity score matching was used to control for confounding factors.ResultsA total of 1,704,708 procedures performed by 4,697 operators were included. Most operators were low‐level adopters (80.7%), followed by intermediate (15.7) and high‐level adopters (3.6%). Compared to the preadoption period, vascular complications of transfemoral PCIs following transradial adoption increased among low‐level adopters (1.29%–1.59%, adjusted OR [95% CI]: 1.24[1.20–1.28], P < 0.001), intermediate‐level adopters (1.37%–1.92%, adjusted OR 1.40[1.29–1.53], P < 0.001), and high‐level adopters (1.54%–1.93%, adjusted OR 1.26[1.00–1.58], P = 0.053).In the post‐adoption period, there was increase in access site bleeding that is likely due to change in registry definition. There was no increase in hematomas, retroperitoneal bleeding or other vascular complications.ConclusionsAdoption of the transradial approach for PCI is not associated with clinically meaningful increase in rates of vascular complications of transfemoral PCIs.
Dual antiplatelet therapy after coronary drug‐eluting stent implantation in China: A large single center study
Authors: Xu Jing‐jing , Gao Zhan , Zhang Yin , Gao Li‐jian , Chen Jue , Qiao Shu‐bin , Gao Run‐lin , Yang Yue‐jin , Xu Bo , Yuan Jin‐qing 
Published: January 2018

AbstractObjectiveTo investigate the actual dual antiplatelet therapy (DAPT) duration after drug‐eluting stent (DES) treatment in China.BackgroundCurrently, less is known about actual DAPT duration after drug‐eluting stent (DES) treatment in China. Here, we performed a study in the largest cardiovascular center in China to investigate DAPT duration and identify associated factors after DES implantation.MethodsA total of 9,919 consecutive patients with DES implantation from January 2013 to December 2013 were enrolled. DAPT cessation was observed, and factors associated with different DAPT durations were analyzed.ResultsThe median follow‐up time was 882 days. The proportion of patients with DAPT coverage at 1‐year of follow‐up was 97.3%, and it decreased to 30.1% for 2 years. The distribution of DAPT duration was not significantly different among patients with acute myocardial infarction (AMI) versus non‐AMI (P = 0.41) and with new‐generation DES versus first‐generation DES (P = 0.54). The multivariable analysis indicated some independent predictors prolonging DAPT duration, including target vessel revascularization (OR 2.50, 95% CI 2.04‐3.06, P < 0.001), stent numbers (OR 1.10, 95% CI 1.05‐1.15, P < 0.001), and previous coronary artery bypass grafting (OR 0.76, 95% CI 0.61‐0.96, P = 0.02). Other clinical factors, such as the increased risk of bleeding and high ischemic risk, were not associated with DAPT duration.ConclusionsThe 1‐year DAPT after DES was applied to 97.3% of Chinese patients in the studied clinical center. However, the DAPT duration after 1 year was not adjusted according to the patients' bleeding situation and ischemic risks.
Direct Conversion of Syngas into Light Olefins over Zirconium‐Doped Indium(III) Oxide and SAPO‐34 Bifunctional Catalysts: Design of Oxide Component and Construction of Reaction Network
Authors: Su Junjie , Wang Dong , Wang Yangdong , Zhou Haibo , Liu Chang , Liu Su , Wang Chuanming , Yang Weimin , Xie Zaiku , He Mingyuan 
Published: January 2018

AbstractThe direct synthesis of light olefins from syngas over a bifunctional catalyst containing an oxide and zeolite has been proven to be a promising strategy. Nevertheless, an unclear reaction network hinders any further enhancement in catalytic performance, such as increasing the conversion of CO. We herein report a novel bifunctional catalyst composed of a InZr binary oxide and SAPO‐34 zeolite displaying superior CO conversion (27.7 %) with selectivity to light olefins (73.6 %) at 400 °C, 2.0 MPa. We demonstrate that the Zr‐doped body‐centered cubic In2O3 phase, exhibiting higher stability than pure In2O3 under a reducing atmosphere, is the active oxide component for the initial activation of CO. A complete reaction network is proposed by DFT calculations and model reactions, revealing that CO activation over Zr‐In2O3 follows a quasi‐CO2 hydrogenation pathway and methanol is the key intermediate to be transformed into light olefins in zeolites. Moreover, inhibiting excessive hydrogenation is an effective strategy to achieve higher performance.
A Highly Reversible Mechanochromic Difluorobenzothiadiazole Dye with Near‐Infrared Emission
Authors: Chen Jianhua , Li Dongyang , Chi Weijie , Liu Guotao , Liu Sheng Hua , Liu Xiaogang , Zhang Chun , Yin Jun 
Published: January 2018

AbstractA difluorobenzothiadiazole‐based fluorescent material with a D‐π‐A‐π‐D structure exhibits a reversible mechanofluorochromic characteristic in the solid state. Its red fluorescent emission switches to near‐infrared fluorescence upon mechanical stimulation, but recover after fuming the ground solid powder with dichloromethane.
Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study
Authors: Pellicori Pierpaolo , Urbinati Alessia , Zhang Jufen , Joseph Anil C. , Costanzo Pierluigi , Lukaschuk Elena , Capucci Alessandro , Cleland John G.F. , Clark Andrew L. 
Published: January 2018

BackgroundThe pulmonary artery (PA) distends as pressure increases.HypothesisThe ratio of PA to aortic (Ao) diameter may be an indicator of pulmonary hypertension and consequently carry prognostic information in patients with chronic heart failure (HF).MethodsPatients with chronic HF and control subjects undergoing cardiac magnetic resonance imaging were evaluated. The main PA diameter and the transverse axial Ao diameter at the level of bifurcation of the main PA were measured. The maximum diameter of both vessels was measured throughout the cardiac cycle and the PA/Ao ratio was calculated.ResultsA total of 384 patients (mean age, 69 years; mean left ventricular ejection fraction, 40%; median NT‐proBNP, 1010 ng/L [interquartile range, 448–2262 ng/L]) and 38 controls were included. Controls and patients with chronic HF had similar maximum Ao and PA diameters and PA/Ao ratio. During a median follow‐up of 1759 days (interquartile range, 998–2269 days), 181 patients with HF were hospitalized for HF or died. Neither PA diameter nor PA/Ao ratio predicted outcome in univariable analysis. In a multivariable model, only age and NT‐proBNP were independent predictors of adverse events.ConclusionsThe PA/Ao ratio is not a useful method to stratify prognosis in patients with HF.
Germline mutation prevalence in individuals with pancreatic cancer and a history of previous malignancy
Authors: Dudley Beth , Karloski Eve , Monzon Federico A. , Singhi Aatur D. , Lincoln Stephen E. , Bahary Nathan , Brand Randall E. 
Published: January 2018

BACKGROUNDApproximately 10% of pancreatic adenocarcinoma (PC) cases are attributed to hereditary causes. Individuals with PC and a personal history of another cancer associated with hereditary breast and ovarian cancer (HBOC) or Lynch syndrome (LS) may be more likely to carry germline mutations.METHODSParticipants with PC and a history of cancer were selected from a pancreatic disease registry. Of 1296 individuals with PC, 149 had a relevant history of cancer. If banked DNA was available, a multigene panel was performed for individuals who had not 1) previously had a mutation identified through clinical testing or 2) undergone clinical multigene panel testing with no mutations detected.RESULTSTwenty‐two of 124 individuals with PC and another HBOC‐ or LS‐related cancer who underwent genetic testing had a mutation identified in a PC susceptibility gene (18%). If prostate cancer is excluded, the mutation prevalence increased to 23% (21/93). Mutation carriers were more likely to have more than 1 previous cancer diagnosis (P = .001), to have had clinical genetic testing (P = .001), and to meet National Comprehensive Cancer Network (NCCN) genetic testing criteria (P < .001). Approximately 23% of mutation carriers did not meet NCCN HBOC or LS testing guidelines based on their personal cancer history and reported cancer history in first‐degree relatives.CONCLUSIONAt least 18% of individuals with PC and a personal history of other HBOC‐ or LS‐related cancers carry mutations in a PC susceptibility gene based on our data, suggesting that criteria for genetic testing in individuals with PC should include consideration of previous cancer history. Cancer 2018;124:1691‐700. © 2018 American Cancer Society
Insulinoma‐associated protein 1 is a sensitive and specific marker of neuroendocrine lung neoplasms in cytology specimens
Authors: Doxtader Erika E. , Mukhopadhyay Sanjay 
Published: January 2018

BACKGROUNDRecent studies suggest that insulinoma‐associated protein 1 (INSM1) is a sensitive and specific marker of neuroendocrine neoplasms. The aims of this study were to determine whether INSM1 can be reliably used in cytology (Cellient) cell blocks, to ascertain whether staining correlates with paired surgical pathology specimens, and to compare its sensitivity and specificity with those of synaptophysin (SYN), chromogranin (CHR), and CD56 for neuroendocrine lung tumors.METHODSSeventy‐four primary lung neoplasms diagnosed on cytology were stained with INSM1, SYN, CHR, and CD56: 41 small cell lung carcinomas (SCLCs), 1 large cell neuroendocrine carcinoma (LCNEC), 10 carcinoid tumors, 11 adenocarcinomas, 9 squamous cell carcinomas, 1 mesothelioma and 1 poorly differentiated non–small cell lung carcinoma, not otherwise specified. In 20 cases, a paired surgical pathology specimen was also stained with INSM1.RESULTSINSM1 was positive in 48 of 52 primary lung neuroendocrine neoplasms (92%), including 38 of 41 SCLCs (93%), the only LCNEC (100%), and 9 of 10 carcinoid tumors (90%), and it was negative in all 22 non‐neuroendocrine primary lung tumors. For SCLC, the sensitivity of INSM1 (93%) was lower than the sensitivity of CD56 (100%), equal to the sensitivity of SYN (93%), and higher than the sensitivity of CHR (35%). For carcinoid tumors, the sensitivity of INSM1 (90%) was lower than the sensitivity of all other markers (100% each). The specificity of INSM1 for neuroendocrine neoplasms as a group was 100%. INSM1 staining was concordant with surgical pathology specimens in all 20 paired cases.CONCLUSIONSINSM1 can be used in cytopathology cell blocks, and it is sensitive and highly specific for neuroendocrine lung tumors. INSM1 staining in cytology cell blocks correlates well with surgical pathology specimens. Cancer Cytopathol 2018;126:243‐52. © 2018 American Cancer Society.
Exploiting the control power of SDN during the transition from IP to SDN networks
Authors: Galán‐Jiménez Jaime 
Published: January 2018

SummaryThe emerging software‐defined networking (SDN) paradigm introduces new opportunities to improve network performance due to the flexibility and programmability provided by a logically centralized element named controller. However, a rapid adoption of the full SDN architecture is difficult in the short term due to economic and technical reasons. This paper faces the SDN nodes replacement problem during the transition from traditional IP networks to fully deployed SDN networks. Six different replacement methods are proposed to select the most appropriate set of traditional IP nodes to be upgraded to SDN‐enabled switches at a particular transition stage. To show the effectiveness of the proposed methods, they have been applied on an optimization problem currently studied by the research community: the power consumption problem. An integer linear programming formulation is presented to solve it and a genetic algorithm is evaluated through simulations on realistic network topologies. Results highlight that energy‐efficiency in hybrid IP/SDN networks can be significantly improved by only replacing a reduced number of IP nodes.
Interactive Tutor Robot for Collaborative e‐Learning System
Authors: TOJO TOSHIYUKI , ONO OSAMU , NOH NORZAIDAH BINTI MD , YUSOF RUBIYAH 
Published: January 2018

SUMMARYIn this paper, we propose Interactive Tutor Robot (ITR) to enhance collaborative e‐Learning system for Science and Technology education field. We implemented the robot with powerful communication specification to e‐Learning contents. It makes learner to get more efficient environment and education contents by a communication with tutor robot interactively. Based on this idea, we defined a simple prototype system to realize an experimental emotion on the target education contents, and tried to confirm a possibility to extend the function for collaborative e‐Learning system according to noble “Qualia” and “Awareness”. We propose one of methods to realize the two above concepts.