bluuebunny/crossref_metadata_2025_split huggingface dataset:
Києво-Покровський жіночий монастир у соціокультурному просторі великого міста другої половини 19 – початку 20 ст.
Authors: Chuchalin Oleksandr 
Published: September 2024

Метою статті є дослідження історії заснування, просторового розвитку, фінансово-господарської та благодійницької діяльності Києво-Покровського жіночого монастиря та з’ясування значення жіночих монастирів та їх чернецтва у соціокультурному просторі великого міста другої половини 19 – початку 20 ст.
Наукова новизна. Досліджено історію Києво-Покровського жіночого монастиря другої половин 19 – початку 20 ст., формування його архітектурно-господарського комплексу, соціального складу черниць, фінансово-господарської діяльності, місця у соціокультурному просторі Києва. До наукового обігу введено архівні матеріали, що відображають різні аспекти історії Києво-Покровського монастиря.
Висновки. Друга половина 19 ст. ознаменувалася зміною урядової політики щодо Російської православної церкви та її монастирів, що дозволило Київській єпархії відновити окремі обителі та заснувати нові монастирі. Києво-Покровський жіночий монастир, заснований у 1889 р., був останнім монастирем збудованим у місті Києві в синодальний період. Однак, за короткий час обитель змогла стати важливим духовним центром, сформувати духовний авторитет черниць та естетичний вплив урочистих монастирських богослужінь, вплинувши на культурну атмосферу великого міста.
Розташування обителі у центральній частині Києва стало вирішальним з точки зору її господарської та соціокультурної діяльності. Статус великого міста та мета його засновниці з організації такого монастиря впливали на формування складу черниць і послушниць, що відрізняло цей монастир від інших обителей єпархії. У першокласні монастирі, до яких належав і Києво-Покровський спільножительний жіночий монастир, частіше вступали представниці дворянського стану. На посаді настоятельниць цього монастиря були, як правило, представниці так званого «освіченого чернецтва».
Соціально-економічні та суспільно-політичні зміни, що припали на другу половину 19 – початок 20 ст. сприяли тому, що традиційно релігійна функція православних монастирів уже не задовольняла потреб поставлених часом. У зв’язку з цим особлива увага приділялася відкриттю при монастирях навчальних закладів, посиленню благодійницької та культурно-просвітницької діяльності. Процеси урбанізації та торгово-промислового розвитку Києва спонукали керівництво та чернецтво монастиря йти в ногу з часом, відповідати запитам оточуючого соціуму. Завдяки монастирям, Київ, в умовах стрімких трансформаційних змін суспільства, продовжував зберігати свій неповторний образ древньої християнської столиці. У той же час монастирі ставали частиною міського середовища, вміло використовуючи результати урбанізації та економічного розвитку, поєднували значення релігійних та історико-культурних центрів. Їх відвідування прочанами та мандрівниками набувало не лише характеру поклоніння святині, але мало і просвітницький характер.
The Agreements Concluded by the Bulgarian State With Foreign Navigation Companies in the International Navigation on the Danube And Black Sea in the late 19th – early 20th centuries
Authors: Mitea Ionel Constantin 
Published: September 2024

The purpose of the research paper is to reveal important moments in the history of international navigation on the Danube and the Black Sea in the late 19th – the early 20th centuries. Considering the broad picture of navigation, we will analyze specific issues related to the steps taken by Bulgaria for the development of navigation activities in its ports aimed at appropriate legislative changes and the conclusion of agreements with foreign shipping companies.
The scientific novelty is given by the analysis of how the approaches of some young riparian states, which wanted to impose their sovereign will and economic interests in their own ports on the Danube and the Black Sea, influenced regional navigation. In this historical context and reference period, we analyse, in detail, the agreements concluded by Bulgaria with foreign shipping companies, French and German, at the early 20th century.
Conclusions. The late 19th – the early 20th centuries faced a particular surge in the presence of navigation companies on the Danube and in the Black Sea ports, marked by the diversification of navigation activities and the establishment of ‘freedom of navigation on the River’, as an expression of ‘European interest’. The Danube ports were still the subject of the great powers’ interest and the shipping companies that stimulated commercial activities on the Maritime Danube.
Bulgaria, a young riparian state to the River that also benefitted from access to the Black Sea, initiated legislative and commercial steps, aiming at economic benefits and international visibility. These initiatives of the Bulgarian authorities expressed the incipient intentions to create a national shipping company that could successfully compete with the already established companies on the Danube and the Black Sea. The purposes of the agreements concluded with the German and French companies were to increase exports through Bulgarian ports and also the efficiency of the activity of the Bulgarian Railways, a vital area of the economy directly related to navigation. The actions of the Bulgarian government contributed substantially to the dynamism of navigation activities on the Danube and the Black Sea.
The biomechanical evaluation of metacarpal fractures fixation methods during finger movements: a finite element study
Authors: Liu Mingrui , Luo Lincong , Lin Tao , Lv Xiaoyu , Vashisth Manoj Kumar , Li Jiaying , Shen Jianlin , Xu Lin , Huang Wenhua 
Published: September 2024

ObjectiveThis study used finite element analysis to simulate four commonly used fixation methods for metacarpal shaft oblique fractures during finger motion and evaluate their biomechanical performance. The aim was to provide evidence for clinically selecting the optimal fixation method, guiding early rehabilitation treatment, and reducing the risk of complications.MethodsFinite element analysis simulated dynamic proximal phalanx motion (60° flexion, 20° extension, 20° adduction, and 20° abduction). We analysed stress, displacement, and distributions for dorsal plates, intramedullary nails, Kirschner wire, and screw fixation methods.ResultsAt 60° of finger flexion and 20° of abduction, plate fixation demonstrated greater stability and minimal displacement, with a peak displacement of 0.19 mm; however, it showed higher stress levels in all motion states, increasing the risk of failure. The stability of the intramedullary nail was similar to that of the dorsal plate, with a maximum displacement difference of 0.04 mm, and it performed better than the dorsal plate during adduction of 20°. Kirschner wire showed the highest stress levels of 81.6 Mpa during finger flexion of 60°, indicating a greater risk of failure and unstable displacement. Screws had lower stress levels in all finger motion states, reducing the risk of failure, but had poorer stability. Stress and displacement distributions showed that the dorsal plate, intramedullary nail, and Kirschner wire mainly bore stress on the implants, concentrating near the fracture line and the proximal metacarpal. In contrast, the screws partially bore stress in the screw group. The anterior end of the metacarpal mainly hosted the maximum displacement.ConclusionThis study demonstrates that under simulated finger motion states, the dorsal plate fixation method provides the best stability in most cases, especially during finger flexion and abduction. However, high stress levels also indicate a higher risk of failure. The intramedullary nail is similar to the dorsal plate in stability and performs better in certain motion states. Kirschner wire exhibits the highest risk of failure during flexion. Although screws have poorer stability in some motion states, they offer a lower risk of failure. These findings provide important reference and surgical selection strategies for treating metacarpal fractures.
Diagnostic value of multimodal ultrasound for breast cancer and prediction of sentinel lymph node metastases
Authors: Li Hui , Chen Lixia , Liu Meikuai , Bao Meng , Zhang Quanbo , Xu Shihao 
Published: September 2024

BackgroundSentinel lymph node metastasis (SLNM) is a critical factor in the prognosis and treatment planning for breast cancer (BC), as it indicates the potential spread of cancer to other parts of the body. The accurate prediction and diagnosis of SLNM are essential for improving clinical outcomes and guiding treatment decisions.ObjectiveThis study aimed to construct a Lasso regression model by integrating multimodal ultrasound (US) techniques, including US, shear wave elastography (SWE), and contrast-enhanced ultrasound (CEUS), to improve the predictive accuracy of sentinel lymph node metastasis in breast cancer and provide more precise guidance for clinical treatment.ResultsA total of 253 eligible samples were screened, of which 148 were group benign and 105 were group malignant. There were statistically significant differences (p &lt; 0.05) between group malignant patients in terms of age, palpable mass, body mass index, distance to nipple, maximum diameter, blood flow, microcalcification, 2D border, 2D morphology, and 2D uniformity and group benign. The Lasso regression model was useful in the diagnosis of benign and malignant nodules with an AUC of 0.966 and in diagnosing SLNM with an AUC of 0.832.ConclusionIn this study, we successfully constructed and validated a Lasso regression model based on the multimodal ultrasound technique for predicting whether SLNM occurs in BCs, showing high diagnostic accuracy.
Association between fatty liver index and cardiometabolic multimorbidity: evidence from the cross-sectional national health and nutrition examination survey
Authors: Gu Xinsheng , Gao Di , Zhou Xinjian , Ding Yueyou , Shi Wenrui , Park Jieun , Wu Shaohui , He Yue 
Published: September 2024

BackgroundMetabolic dysfunction associated steatotic liver disease (MASLD) contributes to the cardiometabolic diseases through multiple mechanisms. Fatty liver index (FLI) has been formulated as a non-invasive, convenient, and cost-effective approach to estimate the degree of MASLD. The current study aims to evaluate the correlation between FLI and the prevalent cardiometabolic multimorbidity (CMM), and to assess the usefulness of FLI to improve the detection of the prevalent CMM in the general population.Methods26,269 subjects were enrolled from the National Health and Nutrition Examination Survey 1999–2018. FLI was formulated based on triglycerides, body mass index, γ -glutamyltransferase, and waist circumference. CMM was defined as a history of 2 or more of diabetes mellitus, stroke, myocardial infarction.ResultsThe prevalence of CMM was 10.84%. With adjustment of demographic, anthropometric, laboratory, and medical history covariates, each standard deviation of FLI leaded to a 58.8% risk increase for the prevalent CMM. The fourth quartile of FLI had a 2.424 times risk for the prevalent CMM than the first quartile, and a trend towards higher risk was observed. Smooth curve fitting showed that the risk for prevalent CMM increased proportionally along with the elevation of FLI. Subgroup analysis demonstrated that the correlation was robust in several conventional subpopulations. Receiver-operating characteristic curve analysis revealed an incremental value of FLI for detecting prevalent CMM when adding it to conventional cardiometabolic risk factors (Area under the curve: 0.920 vs. 0.983, P &lt; 0.001). Results from reclassification analysis confirmed the improvement from FLI.ConclusionOur study demonstrated a positive, linear, and robust correlation between FLI and the prevalent CMM, and our findings implicate the potential usefulness of FLI to improve the detection of prevalent CMM in the general population.
Students' perception of the strengths and weaknesses of the inclusive educational model of Brazilian municipal public schools
Authors: Capellini Vera , Muñoz-Martínez Yolanda , Gómez Puerta Jose Marcos , Reis Verônica Lima dos , Rocha Eduardo Pimentel da 
Published: September 2024

IntroductionBrazil is a signatory of important documents that advocate the promotion and access to equitable, inclusive, and quality education. However, the construction of inclusive policies, practices, and cultures has been little discussed in the country, making the process of educational inclusion of children with specific educational needs difficult.MethodIn this study, we used the Index for Inclusion to investigate children's perceptions considering the three things they like most about their school and the three things they dislike. Data was analyzed qualitatively through content analysis, using prefixed categories created according to the children's answers to the Index (strengths and weaknesses), categorized considering the dimensions and subdimensions assessed by the Index.ResultsThe results revealed that children perceive the infrastructural and urban barriers present in their context, which are considered weaknesses for developing inclusive policies, practices, and cultures in their school contexts. On the other hand, they do not show attitudinal barriers, that is, they do not judge others for their differences.DiscussionWorking on differences, from the first school stage, to build a positive relationship between children and the development of practices and an inclusive school can benefit the construction of a school community free of segregating values present in our culture, contributing to the development of inclusive policies, practices, and cultures in school environments.
Simulation of low-load operation for a 350 MW supercritical unit
Authors: Xu Shiming , Yu Bo , Zhou Qiang , Zhang Xiangyu , Wang Fujun , Zhou Huaichun 
Published: September 2024

Currently, there is a scarcity of studies exploring the safe operating parameters for coal-fired power units at loads below 30%.To accurately understand the operating characteristics of coal-fired units under low load conditions, and to provide a design basis for flexibility modifications, a simulation model coupled with boiler and turbine was established, which includes the flue gas and air system, steam and water system, steam turbine, and steam extraction heat recovery system, and the iterative calculation strategy for low load conditions was proposed. The simulation calculation was performed on a 350 MW supercritical coal-fired unit, with the model results showing a high degree of alignment with the unit’s design and operational parameters. Under the condition of 269MW, the maximum calculation error between the model’s predicted exit flue gas temperature of the air preheater and the actual operational results was 8.84%. This discrepancy was due to a sudden increase in the operating flue gas temperature, which may be associated with a blockage in the air preheater. And the simulation results under low load conditions indicate that when the unit load is below 20%, the furnace total airflow is controlled to no less than 30% of the airflow at Maximum Continuous Rating (BMCR) and the minimum feedwater flow rate can be reduced to 20% of that in Turbine Heat Acceptance (THA) load, and the unit switches to wet state operation around 20% load. As the unit load decreases, the coal consumption rate for power generation and steam turbine heat consumption rate both increase significantly. The coal consumption rate for power generation at 30% load is increased by 13.3% compared to BMCR load, and it is increased by 32.5% at 15% load which is operated in wet state. Under low load conditions, the coal consumption rate of the unit can be reduced by decreasing the oxygen content in the flue gas, reducing the minimum feedwater flow rate, and implementing boiler water recirculation.
Effect of cellulose-lignin ratio on the adsorption of U(Ⅵ) by hydrothermal charcoals prepared from Dendrocalamus farinosus
Authors: Yang FanQin , Li Hanhan , Wang Boya , Fan Wei , Gu Xiaoyan , Cao Ying , Hu Shanglian 
Published: September 2024

Herein, the impact of varying proportions of cellulose/lignin in bamboo on the production of hydrothermal biochar was investigated. Different characterization techniques were applied to explore the structure of hydrothermal biochar derived from three different genotypes (215, 30-A, 52-B) of Dendrocalamus farinosus, and the adsorption behavior of uranium by these hydrothermal biochars was evaluated. It was found that a decrease in cellulose/lignin ratio (3.08, 2.68, and 2.58) positively influenced the specific surface area and pore volume of hydrothermal biochar. Consequently, the prepared hydrothermal biochars exhibited adsorption capacities for U(VI) ions at levels of 14.78 mg/g, 24.68 mg/g, and 26.02 mg/g respectively under these three ratios. The adsorption process by 52-B-220 well complied with the Freundlich isotherm, which indicated that the multi-layer adsorption occurred on the solid liquid interface, but single-layer adsorption was evident in those prepared from genotypes 30-A and 215. This study demonstrated that adjusting biomass feedstock composition as an effective strategy for enhance the quality of biochar.
TUBA1C orchestrates the immunosuppressive tumor microenvironment and resistance to immune checkpoint blockade in clear cell renal cell carcinoma
Authors: Li Junyi , Chen Meixue , Tong Ming , Cao Qingfei 
Published: September 2024

BackgroundClear cell renal cell carcinoma (ccRCC) poses substantial treatment challenges, especially in advanced stages where the efficacy of immune checkpoint blockade (ICB) therapy varies significantly. Elevated expression of the oncogene TUBA1C has been correlated with poor prognosis in various cancers, however, its role in ccRCC is unclear, especially concerning ICB resistance.MethodsSingle-cell analysis was used to examine gene expression variations in malignant cells post-ICB therapy. This included investigating TUBA1C expression across different ICB response groups and its relationship with CD274. A general module of action was identified through pan-cancer and pan-tissue analysis. TUBA1C expression and its association with clinical characteristics and prognosis was further validated. Multiple algorithms were employed to explore immune cell infiltration levels, and the DepMap database was utilized to assess gene dependency and mutation status in kidney cancer cell lines. The in silico knockout of TUBA1C was performed using deep learning model, complemented by immunohistochemical assays, clinical cohort and functional assays validations.ResultsTUBA1C expression is elevated in malignant cells following ICB therapy and is correlated with ICB resistance in ccRCC. High TUBA1C expression activates PI3K/AKT pathway and is associated with increased infiltration of regulatory T cells and myeloid-derived suppressor cells, which contributes to an immunosuppressive microenvironment in ccRCC. Patients with high TUBA1C expression exhibit a greater tumor mutation burden and increased genetic variation, which causes a worse prognosis. Additionally, TUBA1C dependency and its effects were evident in kidney cancer cell lines, where mutations conferred resistance to anti-PD-L1 therapy. In silico knockout analyses indicated that treatment targeting TUBA1C shifted malignant cells to a state responsive to ICB therapy. Immunohistochemistry, RT-qPCR and clinical cohort validation further confirmed that TUBA1C expression was upregulated and contributed to poorer outcome in ccRCC. Finaly, wound healing and CCK-8 assays demonstrated the potent oncogenic function of TUBA1C.ConclusionsTUBA1C is a pivotal regulator in ccRCC, affecting both disease progression and the effectiveness of ICB therapy by fostering an immunosuppressive microenvironment mediated by the PI3K/AKT pathway. Additionally, TUBA1C holds promise, both as a prognostic biomarker and a therapeutic target, for enhancing responsiveness to ICB.
Safety and efficacy of angiotensin receptor neprilysin inhibitor in improving cardiac function and blood pressure in dialysis patients
Authors: Zhou Kai , Zhang Qiuyue , Dong Wen , Li Xin , Sun Yimiao , Zhang Ying 
Published: September 2024

BackgroundThe efficacy of the angiotensin receptor neprilysin inhibitor (ARNI) sacubitril/valsartan (SV) in patients with chronic kidney disease (CKD) has been established. Two meta-analyses have demonstrated its significant role in enhancing ventricular remodeling. However, the effectiveness and safety of its use in patients with end-stage renal disease (ESRD) remain unclear.Methods and resultsUp to October 2023, we searched the PubMed, Embase, and Web of Science databases for studies involving ESRD patients treated with ARNI. The quality of the included studies was evaluated using the Newcastle-Ottawa Scale. Effect sizes were reported as mean differences (MD) with 95% confidence intervals (CIs). We included 10 studies, encompassing 649 patients. ARNI was associated with improvements in blood pressure and left ventricular (LV) function in ESRD patients, including systolic blood pressure (SBP) (MD −12.76 mmHg; 95% CI, −18.03 to −7.5 mmHg), diastolic blood pressure (DBP) (MD −6.41 mmHg; 95% CI, −8.10 to −4.72 mmHg), and left ventricular ejection fraction (LVEF) (MD, 4.61%; 95% CI, 1.78%−7.44%). Hemoglobin levels improved, but there were no significant statistical differences in other biomarkers for dialysis. Sacubitril/valsartan was generally well tolerated in ESRD patients. Improved indices of left ventricular function were noted at 6 months and were more pronounced at 12 months. A linear relationship between LVEF and left ventricular end-diastolic volume (LVEDV) was observed, as indicated by a high correlation coefficient (r-value).ConclusionARNI effectively reduces blood pressure and enhances left ventricular function in dialysis patients, with early treatment associated with greater benefits. ARNI also demonstrates a favorable safety profile in this population. Further prospective studies are required to fully understand the long-term efficacy and safety of sacubitril/valsartan in dialysis patients.