bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of patient‐specific surgical guides for femoral neck cutting in total hip arthroplasty through the anterolateral approach
Authors: Sakai Takashi , Hamada Hidetoshi , Takao Masaki , Murase Tsuyoshi , Yoshikawa Hideki , Sugano Nobuhiko 
Published: May 2017

AbstractBackgroundThe aim of this study was to validate the effectiveness of neck‐cut patient‐specific surgical guides (PSGs) for femoral component implantation in total hip arthroplasty (THA) through the anterolateral approach compared with that without PSG.MethodsA total of 32 fresh cadaveric hips were included. Anatomical stem implantation with wide‐base‐contact PSG (AWP group) and without PSG (control group) were compared. The absolute errors between preoperative planning and PSG setting (E1), as well as those between preoperative planning and postoperative component implantation (E2) were evaluated using CT.ResultsThe E1/E2 values of AWP were 0.9±0.3°/0.6±0.6° in the coronal plane, and 1.7±0.8°/1.0±0.9° in the sagittal plane, and 1.0±0.6 mm/1.0±1.1 mm for the medial height. The E2 value in the sagittal plane (P=0.037) and the medial height (P=0.011) of AWP were significantly smaller than those of control group.ConclusionsThe neck‐cut PSG through the anterolateral approach is effective for femoral component implantation.
Orf virus infection
Authors: Bergqvist Christina , Kurban Mazen , Abbas Ossama 
Published: May 2017

SummaryOrf virus (ORFV) is an important pathogen responsible for a highly contagious zoonotic viral infection that threatens those who handle sheep and goats. Orf virus is the prototype of the Parapoxvirus genus, and its resilience in the environment and ability to reinfect its host has contributed to the spread and maintenance of the infection in many species. In healthy humans, the disease usually resolves spontaneously within 3 to 6 weeks. There is no specific treatment and many different approaches such as use of imiquimod, cidofovir, curettage, shave excision, cryotherapy, and electrocautery have all been reported to be successful, without supporting evidence from controlled clinical trials. Throughout its interaction with the different hosts, ORFV has evolved a strategy for immune evasion via the development of an array of virulence factors. The interaction of ORFV with the immune system has been the subject of research for decades. Whole inactivated ORFV has been used as a type of immunomodulating drug; a so called paramunity inducer proposed as both a preventative and a therapeutic immunomodulator across various species. Additional research on the remarkable strategies underlying ORFV infection could lead to improved understanding of skin immunity.
The Endothelial Protein C Receptor Is a Potential Stem Cell Marker for Epidermal Keratinocytes
Authors: Xue Meilang , Dervish Suat , Chan Benjamin , Jackson Christopher J. 
Published: May 2017

Abstract
Endothelial protein C receptor (EPCR) is a specific receptor for anticoagulant protein C and expressed by human epidermis and cultured keratinocytes. Here we investigated whether: (a) the level of EPCR in keratinocytes is associated with their growth potential; and (b) EPCR is a potential marker for human epidermal stem cells. Human keratinocytes isolated from foreskins or adult skin tissues were transfected with EPCR siRNA or EPCR overexpressing plasmids. Cell proliferation, long term proliferation potential, colony forming efficiency (CFE), and in vitro epidermal regeneration ability of EPCRhigh and EPCRl°w cells were assessed. The expression and colocalization of EPCR with stem cell markers p63, integrin β1, and activation of MAP kinases were detected by flow cytometry, immunofluorescence staining, or Western blot. Results showed that EPCR was highly expressed by the basal layer of skin epidermis. EPCRhigh cells were associated with the highest levels of p63 and integrin β1. Most EPCRhigh cells were smaller in size, formed larger colonies and had a greater long term growth potential, CFE, holoclone formation, and in vitro epidermal regeneration ability when compared to EPCRl°w cells. Blocking EPCR resulted in keratinocyte apoptosis, particularly in nondifferentiated conditions. Cell proliferation and p63 expression were reduced by blocking EPCR and enhanced by overexpressing this receptor. These data indicate that EPCR can regulate p63, is associated with highly proliferative keratinocytes, and is a potential human epidermal stem cell marker.
Cell Therapy in Parkinson's Disease: Host Brain Repair Machinery Gets a Boost From Stem Cell Grafts
Authors: Napoli Eleonora , Borlongan Cesar V. 
Published: May 2017

Abstract
This commentary highlights the major findings and future research directions arising from the recent publication by Zuo and colleagues in Stem Cells 2017 (in press). Here, we discuss the novel observations that transplanted human neural stem cells can induce endogenous brain repair by specifically stimulating a host of regenerative processes in the neurogenic niche (i.e., subventricular zone [SVZ]) in an animal model of Parkinson's disease. That the identified therapeutic proteomes, neurotrophic factors, and anti-inflammatory cytokines in the SVZ may facilitate brain regeneration and behavioral recovery open a new venue of research for our understanding of the pathology and treatment of Parkinson's disease.
Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells
Authors: Tatsumi Ryuichi , Suzuki Takahiro , Do Mai-Khoi Q. , Ohya Yuki , Anderson Judy E. , Shibata Ayumi , Kawaguchi Mai , Ohya Shunpei , Ohtsubo Hideaki , Mizunoya Wataru , Sawano Shoko , Komiya Yusuke , Ichitsubo Riho , Ojima Koichi , Nishimatsu Shin-ichiro , Nohno Tsutomu , Ohsawa Yutaka , Sunada Yoshihide , Nakamura Mako , Furuse Mitsuhiro , Ikeuchi Yoshihide , Nishimura Takanori , Yagi Takeshi , Allen Ronald E. 
Published: May 2017

AbstractRecently, we found that resident myogenic stem satellite cells upregulate a multi-functional secreted protein, semaphorin 3A (Sema3A), exclusively at the early-differentiation phase in response to muscle injury; however, its physiological significance is still unknown. Here we show that Sema3A impacts slow-twitch fiber generation through a signaling pathway, cell-membrane receptor (neuropilin2-plexinA3) → myogenin-myocyte enhancer factor 2D → slow myosin heavy chain. This novel axis was found by small interfering RNA-transfection experiments in myoblast cultures, which also revealed an additional element that Sema3A-neuropilin1/plexinA1, A2 may enhance slow-fiber formation by activating signals that inhibit fast-myosin expression. Importantly, satellite cell-specific Sema3A conditional-knockout adult mice (Pax7CreERT2-Sema3Afl°x activated by tamoxifen-i.p. injection) provided direct in vivo evidence for the Sema3A-driven program, by showing that slow-fiber generation and muscle endurance were diminished after repair from cardiotoxin-injury of gastrocnemius muscle. Overall, the findings highlight an active role for satellite cell-secreted Sema3A ligand as a key “commitment factor” for the slow-fiber population during muscle regeneration. Results extend our understanding of the myogenic stem-cell strategy that regulates fiber-type differentiation and is responsible for skeletal muscle contractility, energy metabolism, fatigue resistance, and its susceptibility to aging and disease.
Adiponectin Enhances Quiescence Exit of Murine Hematopoietic Stem Cells and Hematopoietic Recovery Through mTORC1 Potentiation
Authors: Masamoto Yosuke , Arai Shunya , Sato Tomohiko , Kubota Naoto , Takamoto Iseki , Kadowaki Takashi , Kurokawa Mineo 
Published: May 2017

Abstract
Myelotoxic injury, such as chemotherapeutic agents and ionizing radiation, unlocks the vigorous power of hematopoietic stem cells (HSCs) to replenish the hematopoietic system, making quiescent HSCs enter the cell cycle. Considering that both HSC-intrinsic and -extrinsic mechanisms enforce quiescence of HSCs, the drastic change in bone marrow (BM) environment after injury, represented by massive expansion of BM adipocytes, might trigger HSC activation. BM adipocytes, the major cellular component in the ablated marrow, however, reportedly suppress proliferation of hematopoietic cells, which may indicate the BM adipocytogenesis is an irrational response of injured organism. Given that adipose tissue is an endocrine organ with pleiotropic functions, we hypothesized that adipocyte-derived factors, especially adiponectin, an anti-inflammatory adipokine involved in regulation of granulopoiesis, are implicated in HSC activation. Myeloablative intervention increased BM adiponectin by multiple mechanisms, including adipocyte expansion and increased diffusion from the blood. Adiponectin-null (Adipoq −/−) mice showed delayed hematopoietic recovery after BM injury, with Adipoq−/− HSCs more quiescent and defective in mammalian target of rapamycin complex 1 (mTORC1) activation. Recombinant adiponectin promoted not only HSC activation in vivo but cytokine-induced activation in vitro, and shortened the time for exit from quiescence in an mTORC1-dependent manner. These data illustrate a scarcely-reported example of a cell-extrinsic factor, adiponectin, enhancing quiescence exit of HSCs, and subsequent hematopoietic recovery. Our findings also highlight adipocytes as a source of adiponectin to ensure the proliferative burst of hematopoietic cells in ablated marrow.
Land Use and Salinity Drive Changes in SAV Abundance and Community Composition
Authors: Patrick Christopher J. , Weller Donald E. , Orth Robert J. , Wilcox David J. , Hannam Michael P. 
Published: May 2017

Abstract
Conserving and restoring submerged aquatic vegetation (SAV) are key management goals for estuaries worldwide because SAV integrates many aspects of water quality and provides a wide range of ecosystem services. Management strategies are typically focused on aggregated abundance of several SAV species, because species cannot be easily distinguished in remotely sensed data. Human land use and shoreline alteration have been shown to negatively impact SAV abundance, but the effects have varied with study, spatial scale, and location. The differences in reported effects may be partly due to the focus on abundance, which overlooks within-community and among-community dynamics that generate total SAV abundance. We analyzed long-term SAV aerial survey data (1984–2009) and ground observations of community composition (1984–2012) in subestuaries of Chesapeake Bay to integrate variations in abundance with differences in community composition. We identified five communities (mixed freshwater, milfoil-Zannichellia, mixed mesohaline, Zannichellia, and Ruppia-Zostera). Temporal variations in SAV abundance were more strongly related to community identity than to terrestrial stressors, and responses to stressors differed among communities and among species. In one fifth of the subestuaries, the community identity changed during the study, and the probability of such a change was positively related to the prevalence of riprapped shoreline in the subestuary. Mixed freshwater communities had the highest rates of recovery, and this may have been driven by Hydrilla verticillata, which was the single best predictor of SAV recovery rate. Additional species-specific and community-specific research will likely yield better understanding of the factors affecting community identity and SAV abundance, more accurate predictive models, and more effective management strategies.
Long‐term reliability and stability of behavioral measures among adolescents: The Delay Discounting and Stroop tasks
Authors: Martínez‐Loredo Víctor , Fernández‐Hermida José Ramón , Carballo José Luis , Fernández‐Artamendi Sergio 
Published: May 2017

ABSTRACTDelay Discounting (DD) and the Stroop test are two fundamental tasks for the assessment of impulsivity and inhibitory control, core features of several behavioral disorders. Although the study of reliability and temporal stability is important, only studies with adults and small samples have been carried out. The aim of this study is to assess the one‐year reliability and temporal stability of both tasks among adolescents. A total of 1375 adolescents (M = 13.08 years old, SD = 0.51) made up the final sample (53.5% males). The results showed moderate stability and good reliability for both DD (α = 0.90) and Stroop (α = 0.85). Indices based on the reaction times and not the number of errors are recommended when using the Stroop test. These results support the use of both behavioral tasks in longitudinal research among adolescents.
A regression model for terminal airspace delays
Authors: Çetek F. Aybek , Kantar Y.M. , Cavcar A. 
Published: May 2017

ABSTRACTAir Traffic Management (ATM) research generally focuses on achieving a safer, more effective and economical air traffic system. The current airspace system has become increasingly strained as the demand for air travel has steadily grown. Innovative, proactive and multi-disciplinary approaches to research are needed to solve flight congestion and delays as a consequence of this rapid growth. As a result of this growth, air traffic flow becomes more complex, especially in Terminal Airspaces (TMA) where climb and descent manoeuvres of departing and arriving flights take place around airports. As air traffic demand exceeds the capacity in a TMA, the resultant congestion leads to delays that spread all over the system. Therefore, the reduction of delays is critical for airspace designers to increase customer satisfaction and the perception of service quality. Numerous studies have been conducted to reduce delays within TMAs. This research focuses on defining the causes of delays quantitatively through statistical analysis. The first step was to create a fast-time simulation model of sample airspace for collecting delay data. After building up this model using the SIMMOD fast-time ATM simulation tool, simulation experiments were run to produce various traffic scenarios and to generate traffic delay data. The number of airports, entry points, fixes and flight operations in airspace and the probability of wide-body aircraft were considered as independent variables. The correlations between the considered variables were analysed, and the total delay data was modelled using a linear regression model. The findings of regression model present a statistical approach for airspace designers and air traffic flow planners.
Transparency and Opaqueness in the Chinese ICT Sector: A Critique of Chinese and International Corporate Governance Norms
Authors: HAWES Colin , LI Grace 
Published: May 2017

AbstractThis article critiques the current Chinese corporate governance framework and the OECD Principles of Corporate Governance (OECD Principles) on which the Chinese framework is largely based through detailed analysis of public disclosures by four prominent Chinese internet and communications technology (ICT) firms. These include State-controlled firms (China Telecom & China Mobile), mixed ownership (ZTE), and privately-controlled firms (Huawei Technologies). The article argues that neither Chinese nor international corporate governance norms deal adequately with the complex group structures that are so common among large Chinese firms. It also reveals deficiencies in the rules on independent directors, supervisory committees, and Chinese Communist Party committees as they are applied by Chinese ICT firms. The article concludes with reform proposals that would provide more useful information and better protection to outside investors and public stakeholders in the unique Chinese corporate environment.
Antipsychotic Prescribing Practices in Those with Parkinsonism: Adherence to Guidelines
Authors: Rigby Heather B. , Rehan Sara , Hill-Taylor Barbara , Matheson Kara , Sketris Ingrid 
Published: May 2017

ABSTRACTSeveral evidence-informed treatment guidelines recommend against the use of typical antipsychotics in patients with Parkinson’s disease; of the atypical antipsychotics, clozapine and quetiapine are preferred. The purpose of this study is to determine the frequency with which potentially inappropriate antipsychotics are dispensed to older adults in Nova Scotia who are on levodopa-containing medications. In this cohort, 59.9% were dispensed a preferred atypical antipsychotic and 12.6% a potentially harmful typical antipsychotic. Our results suggest that potentially inappropriate prescribing practices are common in the neuropsychiatric management of patients with parkinsonism and that there is an opportunity for education and improvement in prescribing practices.
METRIC ABSTRACT ELEMENTARY CLASSES AS ACCESSIBLE CATEGORIES
Authors: LIEBERMAN M. , ROSICKÝ J. 
Published: May 2017

AbstractWe show that metric abstract elementary classes (mAECs) are, in the sense of [15], coherent accessible categories with directed colimits, with concrete ℵ1-directed colimits and concrete monomorphisms. More broadly, we define a notion of κ-concrete AEC—an AEC-like category in which only the κ-directed colimits need be concrete—and develop the theory of such categories, beginning with a category-theoretic analogue of Shelah’s Presentation Theorem and a proof of the existence of an Ehrenfeucht–Mostowski functor in case the category is large. For mAECs in particular, arguments refining those in [15] yield a proof that any categorical mAEC is μ-d-stable in many cardinals below the categoricity cardinal.
Institutional Environment and IPO Strategy: A Study of ChiNext in China
Authors: Zhang Jing , Zhang Wei , Schwab Andreas , Zhang Sipei 
Published: May 2017

ABSTRACTTaking an institution-based view, we investigate how entrepreneurs respond to immature regulatory environments in order to be listed on stock markets in countries with an emerging economy. Unlike stock markets in developed countries, in emerging markets, gaining government approval for listing is a critical and more unpredictable process for entrepreneurs. Hence, entrepreneurs who are preparing for a public offering might give substantially discounted shares to venture capital (VC) investors. This will lead to higher investment returns in pre-IPO deals than those at earlier stages, which distorts the risk-return tradeoff found in developed markets. In particular, the VC investors affiliated with powerful organizations that can promise entrepreneurs preferential access to stock market gatekeepers will gain even higher pre-IPO investment returns. The associated additional institutional rents earned by VC investors, however, are expected to decrease over time, as the stock markets mature. Related hypotheses with regard to the investment timing, VC firm affiliations with government agencies, securities traders, and universities are tested using data from ChiNext in China (2009–2013). This study highlights that institutional factors impact the behavior of participants in emerging markets. It extends current theories derived almost exclusively from developed markets.
Investigation of serum levels of sortilin in response to antidepressant treatment
Authors: Buttenschøn Henriette Nørmølle , Nielsen Marit , Glerup Simon , Mors Ole 
Published: May 2017

BackgroundThe identification of biomarkers for depression is of great clinical relevance as the diagnosis is currently subjective. Recent research points towards sortilin as a potential biomarker for depression, and the aim of the current study was to investigate the serum sortilin level in response to antidepressant treatment.MethodsThe study included 56 depressed individuals of which 41 responded to treatment. Depression scores and serum levels of sortilin were measured at baseline and after 12 weeks of antidepressant treatment. Statistical analyses were performed using Stata 13.ResultsThe depression score and response to treatment were not predicted by the sortilin level. Likewise, we observed no significant change in serum sortilin levels following 12 weeks of antidepressant treatment. Furthermore, no association between the serum sortilin level and depression score was observed.ConclusionThe results do not point towards sortilin as a state-dependent biomarker.
Stability and change in dietary scores and patterns across six waves of the Longitudinal Study of Australian Children
Authors: Gasser Constantine E. , Kerr Jessica A. , Mensah Fiona K. , Wake Melissa 
Published: May 2017

AbstractThis study aimed to derive and compare longitudinal trajectories of dietary scores and patterns from 2–3 to 10–11 years and from 4–5 to 14–15 years of age. In waves two to six of the Baby (B) Cohort and one to six of the Kindergarten (K) Cohort of the population-based Longitudinal Study of Australian Children, parents or children reported biennially on the study child’s consumption of twelve to sixteen healthy and less healthy food or drink items for the previous 24 h. For each wave, we derived a dietary score from 0 to 14, based on the 2013 Australian Dietary Guidelines (higher scores indicating healthier diet). We then used factor analyses to empirically derive dietary patterns for separate waves. Using group-based trajectory modelling, we generated trajectories of dietary scores and empirical patterns in 4504 B and 4640 K Cohort children. Four similar trajectories of dietary scores emerged for the B and K Cohorts, containing comparable proportions of children in each cohort: ‘never healthy’ (8·8 and 11·9 %, respectively), ‘moderately healthy’ (24·0 and 20·7 %), ‘becoming less healthy’ (16·6 and 27·3 %) and ‘always healthy’ (50·7 and 40·2 %). Deriving trajectories based on dietary patterns, rather than dietary scores, produced similar findings. For ‘becoming less healthy’ trajectories, dietary quality appeared to worsen from 7 years of age in both cohorts. In conclusion, a brief dietary measure administered repeatedly across childhood generated robust, nuanced dietary trajectories that were replicable across two cohorts and two methodologies. These trajectories appear ideal for future research into dietary determinants and health outcomes.
A systematic review of diet quality indices in relation to obesity
Authors: Asghari Golaleh , Mirmiran Parvin , Yuzbashian Emad , Azizi Fereidoun 
Published: May 2017

AbstractTools, called ‘diet/dietary quality indices’, evaluate the level of adherence to a specified pattern or a set of recommendations in populations. Yet, there are no review studies providing unanimous comprehensive results of dietary indices on obesity. We reviewed observational studies, focusing on the association of diet quality indices with general obesity or abdominal obesity in adults. We systematically conducted a search in all English language publications available on MEDLINE, ISI Web of Science and Embase between January 1990 and January 2016. Among the wide variety of indices and weight-derived variables, studies with dietary-guideline-based indices and mean changes for weight gain or OR for general obesity and abdominal obesity were selected. From a total of 479 articles, thirty-four studies were selected for the current review, ten of which had prospective designs and twenty-six had cross-sectional designs. Associations of weight status with the original Healthy Eating Index (HEI) and other versions of the HEI including alternative HEI, HEI-2005 and HEI-05 were examined in thirteen studies, with ten studies revealing significant associations. The HEI was a better general obesity predictor in men than in women. Diet scores lacked efficacy in assessing overall diet quality and demonstrated no significant findings in developing countries, in comparison with US populations. In addition, indices based on dietary diversity scores were directly associated with weight gain. Despite the insufficient evidence to draw definitive conclusions about the relation between dietary indices and obesity, HEI was found to be inversely associated with obesity and diversity-based indices were positively associated with obesity.