bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renin angiotensin aldosterone system altered in resistant hypertension in Sub-Saharan African diabetes patients without evidence of primary hyperaldosteronism
Authors: Edinga-Melenge Bertille Elodie , Ama Moor Vicky J , Nansseu Jobert Richie N , Nguetse Djoumessi Romance , Mengnjo Michel K , Katte Jean-Claude , Noubiap Jean Jacques N , Sobngwi Eugene 
Published: March 2017

Background The renin-angiotensin-aldosterone system may be altered in patients with resistant hypertension. This study aimed to evaluate the relation between renin-angiotensin-aldosterone system activity and resistant hypertension in Cameroonian diabetes patients with resistant hypertension. Methods We carried out a case-control study including 19 diabetes patients with resistant hypertension and 19 diabetes patients with controlled hypertension matched to cases according to age, sex and duration of hypertension since diagnosis. After collection of data, fasting blood was collected for measurement of sodium, potassium, chloride, active renin and plasma aldosterone of which the aldosterone-renin ratio was derived to assess the activity of renin-angiotensin-aldosterone system. Then, each participant received 2000 ml infusion of saline solution after which plasma aldosterone was re-assayed. Results Potassium levels were lower among cases compared to controls (mean: (4.10 ± 0.63 mmol/l vs. 4.47 ± 0.58 mmol/l), though nonsignificant (p = 0.065). Active renin, plasma aldosterone both before and after the dynamic test and aldosterone-renin ratio were comparable between cases and controls (all p values > 0.05). Plasma aldosterone significantly decreased after the dynamic test in both groups (p < 0.001), but no participant exhibited a post-test value>280 pmol/l. We found a significant negative correlation between potassium ion and plasma aldosterone (ρ = −0.324; p = 0.047), the other correlations being weak and unsignificant. Conclusion Although this study failed to show an association between RH and primary hyperaldosteronism in our context, there was a hyperactivity of renin-angiotensin-aldosterone system. Moreover, this study confirms the importance of potassium dosage when screening the renin-angiotensin-aldosterone system.
Expectancy, usage and acceptance by general practitioners and patients: exploratory results from a study in the German outpatient sector
Authors: Albrecht Urs-Vito , Afshar Kambiz , Illiger Kristin , Becker Stefan , Hartz Tobias , Breil Bernhard , Wichelhaus Daniel , von Jan Ute 
Published: March 2017

Objective The study’s objective was to assess factors contributing to the use of smart devices by general practitioners (GPs) and patients in the health domain, while specifically addressing the situation in Germany, and to determine whether, and if so, how both groups differ in their perceptions of these technologies. Methods GPs and patients of resident practices in the Hannover region, Germany, were surveyed between April and June 2014. A total of 412 GPs in this region were invited by email to participate via an electronic survey, with 50 GPs actually doing so (response rate 12.1%). For surveying the patients, eight regional resident practices were visited by study personnel (once each). Every second patient arriving there (inclusion criteria: of age, fluent in German) was asked to take part (paper-based questionnaire). One hundred and seventy patients participated; 15 patients who did not give consent were excluded. Results The majority of the participating patients (68.2%, 116/170) and GPs (76%, 38/50) owned mobile devices. Of the patients, 49.9% (57/116) already made health-related use of mobile devices; 95% (36/38) of the participating GPs used them in a professional context. For patients, age ( P < 0.001) and education ( P < 0.001) were significant factors, but not gender ( P > 0.99). For doctors, neither age ( P = 0.73), professional experience ( P > 0.99) nor gender ( P = 0.19) influenced usage rates. For patients, the primary use case was obtaining health (service)-related information. For GPs, interprofessional communication and retrieving information were in the foreground. There was little app-related interaction between both groups. Conclusions GPs and patients use smart mobile devices to serve their specific interests. However, the full potentials of mobile technologies for health purposes are not yet being taken advantage of. Doctors as well as other care providers and the patients should work together on exploring and realising the potential benefits of the technology.
Patellar tendon healing after anterior cruciate ligament reconstruction in football players
Authors: Tzoanos Georgios Nikolaos , Tsavalas Nikolaos , Manidakis Nikolaos , Kalliakmanis Alkiviadis 
Published: March 2017

Introduction: To investigate the healing process of the harvested patellar tendon at 12±2 and 24±2 months following Bone-Patellar-Bone (BTB) Anterior Cruciate Ligament (ACL) reconstruction. Methods: 30 football players were enrolled in our study and examined at 12±2 and 24±2 months postoperatively. Donor and contralateral tendons evaluated with a high frequency ultrasound transducer. The maximum anteroposterior (MAP) and maximum transverse (MT) diameters of the patellar tendon and associated defect at the site of the tendon incision measured at its proximal, middle and distal thirds. The presence of vascular flow was examined with Doppler imaging. Echogenicity of the patellar tendon defect was graded as low, mixed or normal compared to the contralateral tendon. Results: There was no statistically significant difference between the mean MAP and MT diameters of the donor tendons at 12±2 and 24±2 months postoperatively (P>0.05). The mean MAP and MT diameters of the patellar tendon defect at 24±2 months were significantly smaller compared to 12±2 months postoperatively (P<0.01). The mean MAP diameter of the harvested tendon was significantly greater at all measured sites in comparison to the contralateral tendon at 12±2 and 24±2 months postoperatively (P<0.01). There was no statistically significant difference between the mean MT diameters of the donor and healthy tendons at 12±2 and 24±2 months postoperatively (P>0.05). At 12±2 months, the mean MAP diameter of the patellar tendon defect was 4.0±2.1 mm, 4.7±2.8 mm and 4.1±2.4 mm at the proximal, middle and distal third of the tendon respectively. The mean MT diameter of the defect was 3.3±2.2 mm (proximal third), 2.9±1.6 mm (middle third) and 2.1±0.9 mm (distal third). 2 of tendon defects showed low echogenicity, 6 mixed echogenicity, 2 patients normal echogenicity. At 24±2 months the mean MAP diameter of the patellar tendon defect was 0.3±0.3 mm, 0.4±0.4 mm and 0.3±0.3 mm at the proximal, middle and distal third of the tendon respectively. The mean MT diameter of the defect was 0.3±0.3 mm (proximal third), 0.2±0.2 mm (middle third) and 0.2±0.2 mm (distal third). 27 of patients demonstrated normal echogenicity, 1 low echogenicity, while 2 mixed echogenicity. No tendon exhibited any signs of neovascularization at 12±2 and 24±2 months postoperatively. Conclusions: Patellar tendons after BTB ACL reconstruction were characterized by increased thickness at 12±2 and 24±2 months postoperatively. Solid healing were evident in 2 patients by 12±2 months and in 27 by 24±2 months. No inflammatory changes were observed at 12±2 and 24±2 months postoperatively. [Figure: see text][Figure: see text]
Optimizing the value of the posterior condylar offset, proximal tibial resection and slope in order to achieve the right balance of the posterior cruciate ligament - clinical application of the molding function of the two parts of the PCL
Authors: Bogojevski Ljubomir , Doksevska Milena Bogojevska 
Published: March 2017

Introduction: In order to achieve the right balance of the posterior cruciate ligament using the skeletal method is very difficult, almost impossible (Mahoney). Our hypothesis for the right balance of the PCL by using the skeletal method is based on several defined facts: - PCL is a union based of two anatomically independent, but functionally synergic parts, posteromedial and anterolateral part. - The length of the posteromedial part of the PCL is determined by the belonging of the medial compartment and is shortest in varus and longest in valgus deformation. - The length of the anterolateral part of the PCL, placed centrally is unchangeable (cca 38 mm) in every knee and is independent from the anatomical appearance (deformation). - The cylindrical shape of the distal posterior part of the femur (Ficat) depends of the molding function of the PCL (Kapandji) and is a result of the proportion of the both parts of the PCL that is consisted of: shorter posteromedial part, less bone stock on the medial and more bone stock on the lateral condyle (varus knee) and vice versa, longer posteromedial part, more bone stock on the medial condyle and less on the lateral (valgus knee). According to that, the neutral bone stock is achieved by equalization of the lengths of the two parts (common radius of the cylinder) of the PCL, that is basis for the interligamentary balance of the posterior cruciate ligament. Methods: The basic characteristics of the interligamentary balance of the PCL that we started in 2008 are the following: 1. Posterior condylar offset is equal to the even length of the both part of the PCL. 2. Decrease of the values of proximal tibial resection from 10 in varus to 4-6 in valgus. 3. Femoral valgus cut from 6 in excessive varus deformity to 4 in valgus. Results: The clinical evaluation of the cases divided in groups excessive varus, mean varus, valgus type 1, 2 (Krakow) showed right distribution in the groups of the postoperative ROM and intraoperative tenacity of the PCL (POLO test and palpation test), as a confirmation to the hypothesis. Conclusions: The ligamentary apparatus of the knee by the molding function depends on the skeletal morphology of the distal posterior femur to the degree that there aren’t two identical knees (Kapandji). According to that, every PCL has its own knee.
Etiological importance of training frequency, age and prevalance of Femoroacetabular İmpingement(FAİ) in pediatric male athletes
Authors: Polat Gökhan , Arzu Ufuk , Dinç Engin , Bayraktar Bülent 
Published: March 2017

Femoroacetabular impingement (FAİ) is a prearthrozic disease that causes hip pain in adolescent-adult patients. The aim of the study is, determining the prevalence of asymptomatic radiographic findings of FAİ, to examine the evaluation of prevalence difference according to age groups and the impact of the levels of physical activity at developmental period on the development of asymptomatic FAİ. Materials-Methods: In our study, we included 214 pediatric athletes from 8 football teams operating in Istanbul between 11-18 years of age in September 2015- January 2016. Ethics Committee approval was obtained for our study. AP pelvis and Frog-leg radiographs, curriculum vitae of the athletes, their injuries, and their realtime complaints have been questioned. The alpha angle, CE angle, Tonnis angle, collodiaphyseal angle is measured from the resulting AP and Frog leg radiographs and terms of morphological abnormalities (FAİ, dysplasia and coxa vara…) was noted. Also athletes dominant feet, weekly training period and the years they play soccer was noted. The obtained data were analyzed by one-way ANOVA and Student-T test. Results: The average age of the 214 pediatric male athletes that included was 15(10-18). Asymptomatic FAİ prevalence of all ages was %29.9, % 0 in the range of 10-12 years, %13.1 in the range of 13-15 years, %45.7 in the 15-18 age range. These findings showed that significantly increased prevalence of FAİ in line with age in pediatric athletes statistically (p <0.05). The mean right hip alpha angle of all athletes was 50.7, left alpha angle was 50.3, right-CE angle was 28.6, left CE angle was 29.5, right Tönnis Angle 6.6, left Tönnis angle 5.0, right neck-shaft angle 133.9, left neck-shaft angle 134.7 degrees found. There was 7 acetabular dysplasia, 56 athletes with CAM type FAS, 4 athletes Pincer type FAS, and 4 combined FAS was found. There was no significant statistical relationship in the prevalences of FAİ between the number of years he worked as an athlete or the side which they hit the ball. However a positive correlation was found between weekly training hours (p <0.05). There were no statistical relationship between morphological abnormalities and previous injuries. Discussion: Among the etiology oriented researches, investigation for developmental factors still continues. İn our study, it is found that the sports activities in the pediatric period that are accused can be a factor in FAİ development due to the positive correlation between pediatric athletes age ang training frequency.
Is it possible to use stress radiographs as a tool to diagnose medial meniscus posterior root tears?
Authors: Daştan Ali Engin , Biçer Elcil Kaya , Kaya Hüseyin , Taşkıran Emin 
Published: March 2017

Aim: Medial meniscus posterior root tear (MMPRT) causes meniscal extrusion, loss of meniscus function, arthritic changes. Clinical history, physical examination and magnetic resonance imaging (MRI) findings are useful for the diagnosis of MMPRT. The aim of this study is to evaluate the utility of stress X-rays in the diagnosis of MMPRT. Methods: Twenty patients who had undergone high tibial osteotomy between March 2015 and May 2016 and whose preoperative bilateral varus and valgus stress x-rays (Telos device) along with weight bearing x-rays were available were included. These patients were grouped into two according to integrity of posterior roots of their medial menisci; there were ten patients both in the study and control groups. Lateral joint space width (LJW) on varus stress x-rays, medial joint space width (MJW) on valgus stress x-rays as well as LJW and MJW on weight bearing x-rays were measured bilaterally. Intragroup comparisons of joint space widths between index and opposite knees were performed. Differences of MJW and LJW between index and opposite knees were calculated. Differences of joint space widths between stress x-rays and weight bearing x-rays were also calculated. The changes in joint space widths between the two groups were compared. Statistical analyses were performed utilizing SPSS 18.0. Significance level was set at 0.05. Results: In MMPRT group, opening of LJ space of index knees under varus stress was greater than that of opposite knees (Index: (mean±SD) 10,27±1,17 mm, opposite: 8,61±1,37 mm; p<0,0001). In the control group the difference was not significant (Index: 9,29±2,55 mm, opposite: 9,68±1,44 mm; p=0,566). The difference in the opening of LJW (under varus stress) between index and opposite knees was significantly greater in the study group (p=0,013). The difference between LJW under weight-bearing and varus stress conditions was significantly greater in the study group. (Study: 3,64±0.217 mm, control:2,28±0,182 mm, p=0.018). Conclusions: The findings of this study showed that in patients who had MMPRTs, an increased opening in the LJW was observed under varus stress conditions. This may be relevant with the fact that when varus stress is applied, meniscal extrusion is increased in case of a MMPRT. Stress x-rays could be a useful tool in the diagnosis of MMPRTs. Further studies are needed to determine the sensitivity and specificity of this diagnostic tool.
Impact on Quality of Life of Patients With Different Knee Pathology and Duration of Rehabilitation
Authors: Canan Gülvin , Çelik Derya 
Published: March 2017

Purpose: Many knee pathologies negatively affects the quality of life of patients. The aim of this study was to determine the relationship between type of pathology, duration of rehabilitation and quality of life. Method: 154 (mean age, 34.74 ± 11.8 years, 73 women) patients with meniscectomy, anterior cruciate ligament reconstruction, and patellofemoral pain syndrome treated conservatively were included in the study. The mean follow-up was 14.5 (range, 8-20) months. The patients were divided into 3 groups; meniscectomy group (Group 1; 52 patients; mean age, 37.0 ± 8.9, 27 women), anterior cruciate ligament reconstruction group (Group 2; 47 patients; mean age, 28.6 ± 8.5 years, 11 women) and patellofemoral pain syndrome group (Group 3; 50 patients; mean age, 37.7 ± 13.6, 35 women). Short Form (SF-36) was used to assess the quality of life. One-way ANOVA was used for statistical analysis with the SPSS 20 software. p <0.05 was considered significant. Results: Group 2 was found significantly younger (p=0.001). The SF-36 subscales exept physical role and mental health were different among groups ( Table 1 ). When this difference was analysed, social, physical and mental health were found to be better in Group 2. [Table: see text] Conclusion: Quality of life and function of the patients appears to be significantly better in the anterior cruciate ligament group. Anterior cruciate ligament injury usually affects the younger population and they have higher motivation for treatment. In addition, we believe that patients takes longer rehabilitation program has better qality of life.
Clinical Effectiveness of Single band Augumentation for Parsiel Anterior Crusiat Ligamet Lesions
Authors: Çiçek Hakan , Tuhanioğlu Ümit , Seyfettinoğlu Fırat , Oğur Hasan Ulaş , Erdoğan Çagrı 
Published: March 2017

The aim of this study is demonsrated of single band augumentation for traumatic partial lesions of the anterior cruciate ligament.Method: A restospecific investigation is performed in our medical clinic to 15 patients suffering from partial anterior cruciate ligament tears and other 15 suffering from total anterior cruciate ligament lesion that were operated between 2012-2014. The time between treatment appointment and patients having preoparative trauma, knee extensor group muscular athrophy; treatment duration, knee movement interval and Lysholm score were investigated ( Table -1 ) [Table: see text] Surgical Technique: Total rupture of the ACL reconstruction was also performed by Anatomical medial portal technique with Hamstring auto graft. Parsiel ACL rupture in; maintaining a solid band with auto graft was augument Hamstring single band with a solid band anatomic medial portal technique.Parsiel load and the same physical therapy protocol was applied to all patients by postoperative day 2. Result: Parsiel or total ACL rupture considering the age range of the patients identified as observed weight in younger age groups. The parsiel lesions of clinical symptoms, late treatment applications to a doctor was observed. Independent from the trauma date, when groups were compared in terms of preoperative extensor total ACL rupture of muscle atrophy, it was also found to be more pronounced. Postoperative clinical score and the Lysholm score was seen as similar to each other. Conclusion: Although the total ACL rupture were also significantly more than the preoperative clinical symptoms parsiel ACL rupture, we believe that the Parsiel ACL ruptures single band augumentasyo the total ACL rupture lesions as successful as treatment outcomes. [Figure: see text][Figure: see text]
As-bearing new mineral species from Valletta mine, Maira Valley, Piedmont, Italy: III. Canosioite, Ba2Fe3+(AsO4)2(OH), description and crystal structure
Authors: Cámara F. , Bittarello E. , Ciriotti M. E. , Nestola F. , Radica F. , Massimi F. , Balestra C. , Bracco R. 
Published: March 2017

AbstractThe new mineral species canosioite, ideally Ba2Fe3+(AsO4)2(OH), has been discovered in the dump of Valletta mine, Maira Valley, Cuneo Province, Piedmont, Italy. Its origin is probably related to the reaction between ore minerals and hydrothermal fluids. It occurs in reddish-brown granules, subhedral millimetre-size crystals, with a pale yellow streak and vitreous lustre. Canosioite is associated with aegirine, baryte, calcite, hematite, bronze Mn-bearing muscovite, unidentified Mn oxides and unidentified arsenates. Canosioite is biaxial (+) with a 2Vmeas= 84(2)°. It is weakly pleochroic withX= brownish yellow,Y= brown,Z= reddish brown,Z>Y>X. Canosioite is monoclinic,P21/m, witha= 7.8642(4),b= 6.1083(3),c= 9.1670(5) Å, β = 112.874(6)°,V= 405.73(4) Å3andZ= 2. Calculated density is 4.943 g cm–3. The seven strongest diffraction lines of the observed powder X-ray diffraction pattern are [din Å, (I) (hkl)]: 3.713 (18)(111), 3.304 (100)(211̄), 3.058 (31)(020), 3.047 (59)(103̄), 2.801 (73)(112), 2.337 (24)(220), 2.158 (24)(123̄). Electron microprobe analyses gave (wt.%): Na2O 0.06, MgO 0.43, CaO 0.02, NiO 0.02, CuO 0.03, SrO 0.42, BaO 49.36, PbO 1.69, Al2O31.25, Mn2O33.89, Fe2O36.95, Sb2O30.01, SiO20.03, P2O50.02, V2O510.88, As2O524.64, SO3 0.01, F 0.02, H2O1.61 was calculated on the basis of 1 (OH,F,H2O) group per formula unit. Infrared spectroscopy confirmed the presence of OH. The empirical formula calculated on the basis of 9 O apfu, is (Ba1.92Pb0.05Sr0.02Na0.01)∑2.00(Fe0.523+Mn0.293+Al0.15Mg0.06)∑1.02[(As0.64V0.36)∑1.00O4]2[(OH0.92F0.01)(H2O)0.07]and the ideal formula is Ba2Fe3+(AsO4)2(OH). The crystal structure was solved by direct methods and found to be isostructural to that of arsenbrackebuschite. The structure model was refined (R1= 2.6%) on the basis of 1245 observed reflections. Canosioite is named after the small municipality of Canosio, where the type locality, the Valletta mine, is situated. The new mineral and name were approved by the International Mineralogical Association Commission on New Minerals and Mineral Names (IMA2015-030).
Stoichiometric partially-protonated states in hydroxide perovskites: the jeanbandyite enigma revisited
Authors: Welch Mark D. , Kampf Anthony R. 
Published: March 2017

AbstractThe original description of the hydroxide perovskite jeanbandyite gives a formula (Fe1–x3+,□x)(Sn1–y,□y) (OH)6 (□= vacancy), which implies the possibility of stoichiometric vacancies at B and B' sites. The validity of this formula has been questioned subsequently. Furthermore, jeanbandyite has metrically a cubic unit cell, but it is optically uniaxial. It is clear that a structure determination is needed to clarify the nature of this enigmatic mineral. Previous studies could find no crystals of sufficient quality for structure determination using X-ray diffractometers available at the time. Crystals of jeanbandyite from Hingston Down, Cornwall, UK and the type locality Llallagua, Bolivia, have been found that are of a quality that allows structure refinement by single-crystal X-ray diffraction. Structural data for crystals from each locality are presented that clarify the nature of jeanbandyite and raise some interesting questions concerning the significance of partially deprotonated states in perovskite-type structures. The structures of both jeanbandyite crystals are cubic with space group Pn3 and unit-cell parameters a = 7.658(2) Å (Llallagua) and 7.6427(2) Å (Hingston). The octahedral tilt system is a+a+a+ and corresponds to that of the aristotype of BB'(OH)6 hydroxide double perovskites. Structure determination demonstrates that B is very Fe3+-rich and B' is filled by Sn, thereby requiring revision of the general jeanbandyite formula to Fex3+Fe(1–x)2+Sn(OH)(6–x)Oxfor 1≥ × > 0.5, with an ideal end-member formula Fe3+Sn(OH)5O. As such, jeanbandyite corresponds to oxidized natanite with partially deprotonated oxygen sites. This stoichiometry cannot be represented in space group Pn3̄ for the observed unit cell as it implies more than one non-equivalent oxygen atom. Consequently, it is inferred that there is no long-range ordering of deprotonated oxygen sites. It is, however, conceivable that the uniaxial optical character of jeanbandyite is linked to the local short-range order of deprotonated domains.
Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells
Authors: Aihara Ayako , Koike Tomo , Abe Natsuki , Nakamura Sou , Sawaguchi Akira , Nakamura Takanori , Sugimoto Naoshi , Nakauchi Hiromitsu , Nishino Taito , Eto Koji 
Published: March 2017

Key Points
TA-316, a novel CMA, enhances human platelet ex vivo generation from iPS cells. TA-316 exhibited biased megakaryopoiesis at levels comparable to rhTPO and superior to eltrombopag.