bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antithrombin III for portal vein thrombosis in patients with liver disease: A randomized, double‐blind, controlled trial
Authors: Hidaka Hisashi , Kokubu Shigehiro , Sato Takahiro , Katsushima Shinji , Izumi Namiki , Igura Takumi , Asahara Shingo , Notsumata Kazuo , Osaki Yukio , Tsuji Keiji , Kawanaka Hirofumi , Akahoshi Tomohiko , Hirota Shozo , Matsutani Shoichi ,   The NPB‐06 study group
Published: June 2017

AimPortal vein thrombosis (PVT) is one of the most critical disorders in liver disease patients. These patients have the imbalance of coagulation and coagulation inhibition resulting from decreased levels of coagulation inhibitory factors, such as protein C, protein S, and antithrombin III (AT‐III). We designed this randomized, double‐blind, placebo‐controlled trial comparing the safety and efficacy of AT‐III for PVT in liver disease patients with those who received no treatment.MethodsEligible patients were diagnosed with the association of thrombus, without tumor thrombus, and thrombus in more than 50% of the cross‐sectional lumen of the portal vein. Patients with 70% or less serum level of AT‐III were included. The study drug was given up to three times in a 5‐day consecutive infusion interval if the thrombus decreased in size. Efficacy was evaluated by contrast enhanced computed tomography using a five‐grade scale (complete response, partial response, slight response, no response, and progression). From October 2014 through to March 2016, 36 patients were randomly assigned to the AT‐III group and 37 patients to the placebo group.ResultsThe proportion of patients with complete response or partial response of PVT was significantly higher in the AT‐III group (55.6%; 20/36 patients; 95% confidence interval, 38.1–72.1) than in the placebo group (19.4%; 7/36 patients, 95% confidence interval, 8.2–36.0) (P = 0.003). The overall incidence of adverse events and adverse drug reactions did not differ significantly between the two groups.ConclusionAntithrombin III is one of the essential therapies for patients with PVT in cases with lower concentration levels of AT‐III.
Evaluating patient and public involvement in health research: from theoretical model to practical workshop
Authors: Gibson Andy , Welsman Jo , Britten Nicky 
Published: June 2017

AbstractBackgroundThere is a growing literature on evaluating aspects of patient and public involvement (PPI). We have suggested that at the core of successful PPI is the dynamic interaction of different forms of knowledge, notably lay and professional. We have developed a four‐dimensional theoretical framework for understanding these interactions.AimWe explore the practical utility of the theoretical framework as a tool for mapping and evaluating the experience of PPI in health services research.MethodsWe conducted three workshops with different PPI groups in which participants were invited to map their PPI experiences on wall charts representing the four dimensions of our framework. The language used to describe the four dimensions was modified to make it more accessible to lay audiences. Participants were given sticky notes to indicate their own positions on the different dimensions and to write explanatory comments if they wished. Participants’ responses were then discussed and analysed as a group.ResultsThe three groups were distinctive in their mapped responses suggesting different experiences in relation to having a strong or weak voice in their organization, having few or many ways of getting involved, addressing organizational or public concerns and believing that the organization was willing to change or not.DiscussionThe framework has practical utility for mapping and evaluating PPI interactions and is sensitive to differences in PPI experiences within and between different organizations. The workshops enabled participants to reflect collaboratively on their experiences with a view to improving PPI experiences and planning for the future.
Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial
Authors: Martinelli M. , Ummarino D. , Giugliano F. P. , Sciorio E. , Tortora C. , Bruzzese D. , De Giovanni D. , Rutigliano I. , Valenti S. , Romano C. , Campanozzi A. , Miele E. , Staiano A. 
Published: June 2017

AbstractBackgroundInfant colic (IC) is a prevalent physiological event of infants, which can disrupt the child's home environment. We aimed to investigate the effectiveness of a mixture of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) compared with Lactobacillus reuteri DSM 17938 and with simethicone for the treatment of IC.MethodsA multicenter randomized comparative study was conducted in infants with colic, according to Rome III criteria, who were randomly assigned to receive M. chamomilla L., M. officinalis L. and tyndallized L. acidophilus (HA122) (Colimil® Plus®; Milte Italia Spa, Milan, Italy) (Group A), L. reuteri DSM 17938 (Group B) and simethicone (Group C). Treatment was given to subjects for 28 days.Key ResultsOne‐hundred and seventy‐six patients completed the study. Mean daily crying time at day 28 was significantly lower in group A (−44, 95% CI: −58 to −30, P<.001) and group B (−35, 95% CI: −49 to −20, P<.001) when compared to group C. No significant difference was observed between Group A and Group B (mean difference: −9 minutes, 95% CI −23 to +5, P=.205). At day 28, 39 of 57 (68.4%) of infants in Group C responded to the treatment compared with 57 out of 60 patients (95%) of Group A and 51 out of 59 (86.4%) of Group B (P<.001).ConclusionsThis study suggests that administration of M. chamomilla L., M. officinalis L. and tyndallized L. acidophilus (HA122) and L. reuteri DSM 17938 are significantly more effective than simethicone in IC. Clinical Trial Registration: ClinicalTrials.gov: NCT02708238.
Care as narrative practice in the context of long‐term care: Theoretical considerations
Authors: Berendonk Charlotte , Blix Bodil Hansen , Randall William L. , Baldwin Clive , Caine Vera 
Published: June 2017

Aims and objectivesIn this article, we introduce care itself as a narrative practice. We emphasise that all interactions between care providers and older adults in long‐term care settings are narrative in nature and foreground experience.BackgroundEvery person consists of innumerable stories based on experiences over time. Some experiences can be recalled and told as narratives, while others are inscribed into our bodies; they are embodied. These narratives shape who we are and are becoming, and influence how care providers experience and provide nursing care in long‐term care settings.Main contributions of the theoretical considerationsWe highlight the importance of stories to narrative identities and focus on the embodied act of coconstructing new stories in interaction. We emphasise the idea that care in gerontological nursing would benefit from acknowledging and fostering embodied narratives in a systematic way with older adults.ConclusionsTo foster, elicit, and coconstruct evolving and forward‐looking narratives based on older adults' verbal and embodied narratives is essential for the quality of care in long‐term settings. Care providers must be aware that they are co‐authors of older adults' continuous storying and restorying of their lives.Implications for practiceTo recognise that both residents and care providers are narrative beings shift the current culture of care away from rationalised and emotionally devoid consequences of care. Understanding the theoretical underpinnings of care itself as narrative practice is a first step in developing care practices that place relationships between residents and care providers at the centre of practice. There is a need for the implementation of strategies to think and work narratively in long‐term care settings.
Radial Extracorporeal Shock Wave Therapy for Relief of Arthralgia in Rheumatoid Arthritis
Authors: Liu Yiming , Zhang Tingjie , Feng Yi 
Published: June 2017

AbstractMore than one‐third of the population with rheumatoid arthritis requires adjuvant analgesic treatment after antirheumatic therapy. In addition to analgesics, another option is radial extracorporeal shock wave therapy (rESWT), a novel physical therapy that has been successfully used in the treatment of many types of chronic soft tissue pain. We report a series of 15 patients who suffered from arthralgia after being on disease‐modifying antirheumatic drugs for more than 3 months. Participants received rESWT for 3 months as an adjuvant therapy. Compared to the pretherapy baseline, follow‐up at 3 months post‐therapy revealed a significant reduction in resting state visual analog scale scores from 2.90 ± 0.74 to 0.80 ± 0.79 (P = 0.004), active state visual analog scale scores from 5.70 ± 1.33 to 2.20 ± 0.63 (P < 0.001), morning stiffness duration from 2.25 ± 0.79 to 1.05 ± 0.69 hours (P = 0.004), disease activity score with 28‐joint counts based on erythrocyte sedimentation rate from 6.34 ± 0.72 to 4.19 ± 0.59 (P = 0.001), and Health Assessment Questionnaire scores from 10.20 ± 2.35 to 5.00 ± 2.62 (P = 0.005). The pre–post changes in erythrocyte sedimentation rate and C‐reactive protein were not statistically significant. By the end of treatment, 11 participants stopped analgesics completely; the other 4 participants were on a smaller dosage. No severe adverse effects related to rESWT were observed. To our knowledge, this is the first report using this therapy to treat arthralgia in rheumatoid arthritis.
Economic Transition, Urban Hierarchy, and Service Industry Growth in China
Authors: Zhong Yun , Wei Yehua Dennis 
Published: June 2017

AbstractThe service industry in China has been undergoing rapid growth, especially since the early 1990s. However, little research has been conducted regarding its characteristics, spatial patterns and dynamics. Based on the theories of economic growth, economic transition and urban hierarchy, this paper develops an analytical framework for elucidating the growth of the service industry in China. We find that cities with a high increment in the service industry tend to be located in coastal areas, and mainly constitute megacities and large, highly developed cities. Cities with higher administrative rank, such as centrally administrated municipalities, cities designated in the State Plan and provincial capitals, maintain relatively high growth in the service industry. It is concluded that China's economic transition and urban hierarchy play significant roles in the growth of the service industry, suggesting that service industry growth in China does not strictly adhere to growth patterns observed in Western countries.
Draft Genome Sequence of Kingella negevensis SW7208426, the First European Strain of
K. negevensis
Isolated from a Healthy Child in Switzerland
Authors: El Houmami Nawal , Schrenzel Jacques , Yagupsky Pablo , Robert Catherine , Ceroni Dimitri , Raoult Didier , Fournier Pierre-Edouard 
Published: June 2017

ABSTRACT

We report here the draft genome of
Kingella negevensis
strain SW7208426, isolated from the oropharynx of a healthy 6-year-old boy in Geneva, Switzerland. To our knowledge, this is the first genome report of the newly described
K. negevensis
species from Europe.
Medical judgement analogue studies with applications to spaceflight crew medical officer
Authors: McCarroll Michele L , Ahmed Rami A , Schwartz Alan , Gothard Michael David , Atkinson Steven Scott , Hughes Patrick , Brito Jose Cepeda , Assad Lori , Myers Jerry , George Richard L 
Published: June 2017

BackgroundThe National Aeronautics and Space Administration (NASA) developed plans for potential emergency conditions from the Exploration Medical Conditions List. In an effort to mitigate conditions on the Exploration Medical Conditions List, NASA implemented a crew medical officer (CMO) designation for eligible astronauts. This pilot study aims to add knowledge that could be used in the Integrated Medical Model.MethodsAn analogue population was recruited for two categories: administrative physicians (AP) representing the physician CMOs and technical professionals (TP) representing the non-physician CMOs. Participants completed four medical simulations focused on abdominal pain: cholecystitis (CH) and renal colic (RC) and chest pain: cardiac ischaemia (STEMI; ST-segment elevation myocardial infarction) and pneumothorax (PX). The Medical Judgment Metric (MJM) was used to evaluate medical decision making.ResultsThere were no significant differences between the AP and TP groups in age, gender, race, ethnicity, education and baseline heart rate. Significant differences were noted in MJM average rater scores in AP versus TP in CH: 13.0 (±2.25), 4.5 (±0.48), p=<0.001; RC: 12.3 (±2.66), 4.8 (±0.94); STEMI: 12.1 (±3.33), 4.9 (±0.56); and PX: 13.5 (±2.53), 5.3 (±1.01), respectively.DiscussionThere could be a positive effect on crew health risk by having a physician CMO. The MJM demonstrated the ability to quantify medical judgement between the two analogue groups of spaceflight CMOs. Future studies should incorporate the MJM in a larger analogue population study to assess the medical risk for spaceflight crewmembers.
Comparative evaluation of six chromogenic media for presumptive yeast identification
Authors: Vecchione Alessandra , Florio Walter , Celandroni Francesco , Barnini Simona , Lupetti Antonella , Ghelardi Emilia 
Published: June 2017

AimsThe present study was undertaken to evaluate the discrimination ability of six chromogenic media in presumptive yeast identification.MethodsWe analysed 108 clinical isolates and reference strains belonging to eight different species:Candida albicans,Candida dubliniensis,Candida tropicalis,Candida krusei,Candida glabrata,Candida parapsilosis,Candida lusitaniaeandTrichosporon mucoides.ResultsC. albicans,C. tropicalisandC. kruseicould be distinguished from one another in all the tested chromogenic media, as predicted by the manufacturers. In addition,C. albicanscould be distinguished fromC. dubliniensison BBL CHROMagar Candida, Kima CHROMagar Candida and Brilliance Candida, andC. parapsilosiscould be identified on CHROMATIC Candida agar, CHROMOGENIC Candida agar, and Brilliance Candida agar.ConclusionsBrilliance Candida provided the widest discrimination ability, being able to discriminate five out of the sevenCandidaspecies tested. Interestingly,C. tropicalisandC. kruseicould be already distinguished from each other after 24 hours of incubation.
Tax Evasion and Multi-Agent-Based Model on Various Topologies
Authors: Lima F. W. S. 
Published: June 2017

In this work, we use Monte-Carlo simulations to study the control of the fluctuations for tax evasion in the economics model proposed by [G. Zaklan, F. Westerhoff and D. Stauffer, J. Econ. Interact. Coordination. 4 (2009) 1; G. Zaklam, F.W.S. Lima and F. Westerhofd, Physica A 387 (2008) 5857.] via a nonequilibrium model with two states ([Formula: see text]) and a noise [Formula: see text] proposed for [M. J. Oliveira, J. Stat. Phys. 66 (1992) 273] and known as Majority-Vote model (MVM) and Sánchez–López-Rodríguez model on communities of agents or persons on some topologies as directed and undirected Barabási–Albert networks and Erdös–Rényi random graphs, Apollonian networks, directed small-world networks and Stauffer–Hohnisch–Pittnauer networks. The MVM is applied around the noise critical [Formula: see text] to evolve the Zaklan model.
CACTI 7
Authors: Balasubramonian Rajeev , Kahng Andrew B. , Muralimanohar Naveen , Shafiee Ali , Srinivas Vaishnav 
Published: June 2017

Historically, server designers have opted for simple memory systems by picking one of a few commoditized DDR memory products. We are already witnessing a major upheaval in the off-chip memory hierarchy, with the introduction of many new memory products—buffer-on-board, LRDIMM, HMC, HBM, and NVMs, to name a few. Given the plethora of choices, it is expected that different vendors will adopt different strategies for their high-capacity memory systems, often deviating from DDR standards and/or integrating new functionality within memory systems. These strategies will likely differ in their choice of interconnect and topology, with a significant fraction of memory energy being dissipated in I/O and data movement. To make the case for memory interconnect specialization, this paper makes three contributions.
First, we design a tool that carefully models I/O power in the memory system, explores the design space, and gives the user the ability to define new types of memory interconnects/topologies. The tool is validated against SPICE models, and is integrated into version 7 of the popular CACTI package. Our analysis with the tool shows that several design parameters have a significant impact on I/O power.
We then use the tool to help craft novel specialized memory system channels. We introduce a new relay-on-board chip that partitions a DDR channel into multiple cascaded channels. We show that this simple change to the channel topology can improve performance by 22% for DDR DRAM and lower cost by up to 65% for DDR DRAM. This new architecture does not require any changes to DIMMs, and it efficiently supports hybrid DRAM/NVM systems.
Finally, as an example of a more disruptive architecture, we design a custom DIMM and parallel bus that moves away from the DDR3/DDR4 standards. To reduce energy and improve performance, the baseline data channel is split into three narrow parallel channels and the on-DIMM interconnects are operated at a lower frequency. In addition, this allows us to design a two-tier error protection strategy that reduces data transfers on the interconnect. This architecture yields a performance improvement of 18% and a memory power reduction of 23%.
The cascaded channel and narrow channel architectures serve as case studies for the new tool and show the potential for benefit from re-organizing basic memory interconnects.
Determinants of postprandial plasma bile acid kinetics in human volunteers
Authors: Fiamoncini Jarlei , Yiorkas Andrianos M. , Gedrich Kurt , Rundle Milena , Alsters Sanne I. , Roeselers Guus , van den Broek Tim J. , Clavel Thomas , Lagkouvardos Ilias , Wopereis Suzan , Frost Gary , van Ommen Ben , Blakemore Alexandra I. , Daniel Hannelore 
Published: June 2017

Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women ( n = 72, 62 ± 8 yr, mean ± SE) were enrolled into a 12-wk weight loss intervention. All subjects underwent an oral glucose tolerance test and a mixed-meal tolerance test before and after the intervention. BA were quantified in plasma by liquid chromatography-tandem mass spectrometry combined with whole genome exome sequencing and fecal microbiota profiling. Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma BA profiles. Fasting and postprandial BA profiles revealed high interindividual variability, and three main patterns in postprandial BA response were identified using multivariate analysis. Although the women enrolled were postmenopausal, effects of sex difference in BA response were evident. Exome data revealed the contribution of preselected genes to the observed interindividual variability. In particular, a variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases. Fecal microbiota analysis did not reveal evidence for a significant influence of bacterial diversity and/or composition on plasma BA profiles. The analysis of plasma BA profiles in response to two different dietary challenges revealed a high interindividual variability, which was mainly determined by genetics and sex difference of host with minimal effects of the microbiota.NEW & NOTEWORTHY Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma bile acid (BA) profiles. Despite high interindividual variability, three main patterns in postprandial BA response were identified using multivariate analysis. A variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases in response to both the oral glucose tolerance test and the mixed-meal tolerance test.
Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Authors: Vivian Carolyn J. , Brinker Amanda E. , Graw Stefan , Koestler Devin C. , Legendre Christophe , Gooden Gerald C. , Salhia Bodour , Welch Danny R. 
Published: June 2017

AbstractMitochondrial DNA (mtDNA) mutations and polymorphisms contribute to many complex diseases, including cancer. Using a unique mouse model that contains nDNA from one mouse strain and homoplasmic mitochondrial haplotypes from different mouse strain(s)—designated Mitochondrial Nuclear Exchange (MNX)—we showed that mtDNA could alter mammary tumor metastasis. Because retrograde and anterograde communication exists between the nuclear and mitochondrial genomes, we hypothesized that there are differential mtDNA-driven changes in nuclear (n)DNA expression and DNA methylation. Genome-wide nDNA methylation and gene expression were measured in harvested brain tissue from paired wild-type and MNX mice. Selective differential DNA methylation and gene expression were observed between strains having identical nDNA, but different mtDNA. These observations provide insights into how mtDNA could be altering epigenetic regulation and thereby contribute to the pathogenesis of metastasis. Cancer Res; 77(22); 6202–14. ©2017 AACR.
Detection and Attribution of Multivariate Climate Change Signals Using Discriminant Analysis and Bayesian Theorem
Authors: Paeth Heiko , Pollinger Felix , Ring Christoph 
Published: June 2017

Abstract
Detection and attribution methods in climatological research aim at assessing whether observed climate anomalies and trends are still consistent with the range of natural climate variations or rather an indication of anthropogenic climate change. In this study, the authors pursue a novel approach by using discriminant analysis to enhance the distinction between past and future climates from state-of-the-art climate model simulations. The method is based on multivariate fingerprints that are defined in the space of several prominent climate indices representing the thermal, dynamical, and hygric aspects of climate change. Attribution is carried out by means of a Bayesian classification approach.
The leading discriminant function accounts for more than 99% of total discriminability, with temperature variables, extratropical precipitation, and extratropical circulation modes mainly contributing to the discriminant power. The misclassification probability between probability density functions of past and future climates is substantially reduced by the discriminant analysis: from &gt;50% to &lt;15%. Since the mid-1980s, the observed anomalies of the considered climate indices are more or less consistently attributed to a climate under strong radiative forcing, projected for the first half of the twenty-first century. The authors also assess the sensitivity of their results to different emissions scenarios from the CMIP3 and CMIP5 multimodel ensembles, seasons, prior probabilities for the early twenty-first-century climate, estimates of the observational error, low-pass filters, variable compositions, group numbers, and reference data.