bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of zoonotic pathogens carried by house mouse and black rat populations in Yucatan, Mexico
Authors: PANTI-MAY J. A. , DE ANDRADE R. R. C. , GURUBEL-GONZÁLEZ Y. , PALOMO-ARJONA E. , SODÁ-TAMAYO L. , MEZA-SULÚ J. , RAMÍREZ-SIERRA M. , DUMONTEIL E. , VIDAL-MARTÍNEZ V. M. , MACHAÍN-WILLIAMS C. , DE OLIVEIRA D. , REIS M. G. , TORRES-CASTRO M. A. , ROBLES M. R. , HERNÁNDEZ-BETANCOURT S. F. , COSTA F. 
Published: July 2017

SUMMARYThe house mouse (Mus musculus) and the black rat (Rattus rattus) are reservoir hosts for zoonotic pathogens, several of which cause neglected tropical diseases (NTDs). Studies of the prevalence of these NTD-causing zoonotic pathogens, in house mice and black rats from tropical residential areas are scarce. Three hundred and two house mice and 161 black rats were trapped in 2013 from two urban neighbourhoods and a rural village in Yucatan, Mexico, and subsequently tested forTrypanosoma cruzi,Hymenolepis diminutaandLeptospira interrogans. Using the polymerase chain reaction we detectedT. cruziDNA in the hearts of 4·9% (8/165) and 6·2% (7/113) of house mice and black rats, respectively. We applied the sedimentation technique to detect eggs ofH. diminutain 0·5% (1/182) and 14·2% (15/106) of house mice and black rats, respectively. Through the immunofluorescent imprint method,L. interroganswas identified in 0·9% (1/106) of rat kidney impressions. Our results suggest that the black rat could be an important reservoir forT. cruziandH. diminutain the studied sites. Further studies examining seasonal and geographical patterns could increase our knowledge on the epidemiology of these pathogens in Mexico and the risk to public health posed by rodents.
Exploring the hidden interior of the Earth with directional neutrino measurements
Authors: Leyton Michael , Dye Stephen , Monroe Jocelyn 
Published: July 2017

AbstractRoughly 40% of the Earth’s total heat flow is powered by radioactive decays in the crust and mantle. Geo-neutrinos produced by these decays provide important clues about the origin, formation and thermal evolution of our planet, as well as the composition of its interior. Previous measurements of geo-neutrinos have all relied on the detection of inverse beta decay reactions, which are insensitive to the contribution from potassium and do not provide model-independent information about the spatial distribution of geo-neutrino sources within the Earth. Here we present a method for measuring previously unresolved components of Earth’s radiogenic heating using neutrino-electron elastic scattering and low-background, direction-sensitive tracking detectors. We calculate the exposures needed to probe various contributions to the total geo-neutrino flux, specifically those associated to potassium, the mantle and the core. The measurements proposed here chart a course for pioneering exploration of the veiled inner workings of the Earth.
An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
Authors: Batinovic Steven , McHugh Emma , Chisholm Scott A. , Matthews Kathryn , Liu Boiyin , Dumont Laure , Charnaud Sarah C. , Schneider Molly Parkyn , Gilson Paul R. , de Koning-Ward Tania F. , Dixon Matthew W. A. , Tilley Leann 
Published: July 2017

AbstractThe malaria parasite,Plasmodium falciparum, displays theP. falciparumerythrocyte membrane protein 1 (PfEMP1) on the surface of infected red blood cells (RBCs). We here examine the physical organization ofPfEMP1 trafficking intermediates in infected RBCs and determine interacting partners using an epitope-tagged minimal construct (PfEMP1B). We show that parasitophorous vacuole (PV)-locatedPfEMP1B interacts with components of the PTEX (PlasmodiumTranslocon of EXported proteins) as well as a novel protein complex, EPIC (Exported Protein-Interacting Complex). Within the RBC cytoplasmPfEMP1B interacts with components of the Maurer’s clefts and the RBC chaperonin complex. We define the EPIC interactome and, using an inducible knockdown approach, show that depletion of one of its components, the parasitophorous vacuolar protein-1 (PV1), results in altered knob morphology, reduced cell rigidity and decreased binding to CD36. Accordingly, we show that deletion of thePlasmodiumbergheihomologue of PV1 is associated with attenuation of parasite virulencein vivo.
Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells
Authors: Huang H-L , Wu H-Y , Chu P-C , Lai I-L , Huang P-H , Kulp S K , Pan S-L , Teng C-M , Chen C-S 
Published: July 2017

AbstractMUC1-C overexpression has been associated with the progression of pancreatic tumors by promoting the aggressive and metastatic phenotypes. As MUC1 is a STAT3 target gene, STAT3 plays a major role in regulating MUC1-C expression. In this study, we report an alternative mechanism by which integrin-linked kinase (ILK) post-transcriptionally modulates the expression of MUC1-C by maintaining its protein stability in pancreatic cancer cells. We found that ILK acts in concert with STAT3 to facilitate IL-6-mediated upregulation of MUC1-C; ILK depletion was equally effective as STAT3 depletion in abolishing IL-6-induced MUC1-C overexpression without disturbing the phosphorylation or cellular distribution of STAT3. Conversely, ectopic expression of constitutively active ILK increased MUC1-C expression, though this increase was not noted with kinase-dead ILK. This finding suggests the requirement of the kinase activity of ILK in regulating MUC1-C stability, which was confirmed by using the ILK kinase inhibitor T315. Furthermore, our data suggest the involvement of protein kinase C (PKC)δ in mediating the suppressive effect of ILK inhibition on MUC1-C repression. For example, co-immunoprecipitation analysis indicated that ILK depletion-mediated MUC1-C phosphorylation was accompanied by increased phosphorylation of PKCδ at the activation loop Thr-507 and increased binding of PKCδ to MUC1-C. Conversely, ILK overexpression resulted in decreased PKCδ phosphorylation. From a mechanistic perspective, the present finding, together with our recent report that ILK controls the expression of oncogenic KRAS through a regulatory loop, underscores the pivotal role of ILK in promoting pancreatic cancer progression.
The movement of small insects in the convective boundary layer: linking patterns to processes
Authors: Wainwright Charlotte E. , Stepanian Phillip M. , Reynolds Don R. , Reynolds Andy M. 
Published: July 2017

AbstractIn fine warm weather, the daytime convective atmosphere over land areas is full of small migrant insects, among them serious pests (e.g. some species of aphid), but also many beneficial species (e.g. natural enemies of pests). For many years intensive aerial trapping studies were the only way of determining the density profiles of these small insects, and for taxon-specific studies trapping is still necessary. However, if we wish to determine generic behavioural responses to air movements shown by small day-migrating insects as a whole, the combination of millimetre-wavelength ‘cloud radars’ and Doppler lidar now provides virtually ideal instrumentation. Here we examine the net vertical velocities of > 1 million insect targets, relative to the vertical motion of the air in which they are flying, as a succession of fair-weather convective cells pass over the recording site in Oklahoma, USA. The resulting velocity measurements are interpreted in terms of the flight behaviours of small insects. These behaviours are accounted for by a newly-developed Lagrangian stochastic model of weakly-flying insect movements in the convective boundary layer; a model which is consistent with classic characterisations of small insect aerial density profiles. We thereby link patterns to processes.
Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015
Authors: Song Jinhua , Zhang Yan , Wang Huiling , Shi Jing , Sun Liwei , Zhang Xiaojie , Yang Zifeng , Guan Wenda , Zhang Hong , Yu Pengbo , Xie Zhengde , Cui Aili , Ng Teresa I. , Xu Wenbo 
Published: July 2017

AbstractA molecular epidemiological study of human respiratory syncytial virus (HRSV) was conducted to examine the distribution of its subgroups and genotypes, as well as to identify its transmission pattern in China. A total of 705 samples collected from 9 provinces in China between January 2008 and February 2015 were identified as HRSV-positive and were subsequently sequenced. Of these, 336 samples were HRSV subgroup A (HRSVA), 368 samples were HRSV subgroup B (HRSVB), and 1 sample contained both HRSVA and HRSVB. These 705 HRSV sequences, together with 766 HRSV sequences downloaded from GenBank, were analyzed to understand the recent circulation patterns of HRSV in China. HRSVB predominated in the 2008/2009 and 2009/2010 seasons, whereas HRSVA predominated in the 2010/2011 and 2011/2012 seasons; HRSVA and HRSVB co-circulated during 2012/2013 and 2014/2015. Phylogenetic analysis showed most of the HRSVA sequences clustered into 2 genotypes, namely, NA1 and ON1. The ON1 genotype was first detected in China in 2011, and it quickly replaced the NA1 genotype to become the most prevalent HRSVA genotype circulating in China between 2013 and 2015. Continuous epidemiological surveillance and molecular characterization of HRSV should be conducted to monitor the evolution of HRSV in China.
Prospective evaluation of the diagnostic value of plasma apelin 12 levels for differentiating patients with moyamoya and intracranial atherosclerotic diseases
Authors: Hu Wei , Jiang Wan , Ye Li , Tian Yanghua , Shen Bing , Wang Kai 
Published: July 2017

AbstractPatients with moyamoya disease (MMD) or intracranial atherosclerotic disease (ICAD) experience similar cerebral ischaemic events. However, MMD patients show greater angiogenesis and arteriogenesis, which play crucial roles in collateral circulation development to enhance clinical prognosis and outcome. Apelins have been associated with angiogenesis and arteriogenesis. Therefore, the aim of the present study was to determine whether apelin levels were higher in patients with MMD than in patients with ICAD or in healthy controls. We compared plasma apelin levels in 29 patients with MMD, 82 patients with ICAD, and 25 healthy participants. Twelve-hour fasting blood samples were collected and analysed using commercially available kits. Univariate analyses indicated that compared with the ICAD and healthy control groups, the MMD group had higher apelin-12, apelin-13, apelin-36, and nitric oxide levels. Binary logistic regression analyses further showed that the plasma apelin-12 level was substantially higher in MMD patients than in ICAD patients. Patients with MMD were also differentiated from patients with ICAD by their mean ages, with the former being younger. Therefore, the plasma apelin-12 level is a potential diagnostic marker for differentiating MMD and ICAD and may provide a treatment strategy for enhancing collateral circulation development and clinical prognosis and outcome.
Self-affirmation facilitates minority middle schoolers' progress along college trajectories
Authors: Goyer J. Parker , Garcia Julio , Purdie-Vaughns Valerie , Binning Kevin R. , Cook Jonathan E. , Reeves Stephanie L. , Apfel Nancy , Taborsky-Barba Suzanne , Sherman David K. , Cohen Geoffrey L. 
Published: July 2017

Significance
This research represents an experimental investigation of how a psychological process unfolds over many years to affect success at a later period of transition, even almost a decade later. A series of 15-min reflective writing exercises not only closed academic performance gaps in early adolescence but, years later, improved drivers of academic and economic opportunity among minority youth: high school course choices, college enrollment, and 4-y college selectivity. Long-term benefits occurred despite the barriers that confront minority students on the path to college. A psychological intervention can have a persistent positive effect when it ushers people onto positive structural pathways.
Intact piRNA pathway prevents L1 mobilization in male meiosis
Authors: Newkirk Simon J. , Lee Suman , Grandi Fiorella C. , Gaysinskaya Valeriya , Rosser James M. , Vanden Berg Nicole , Hogarth Cathryn A. , Marchetto Maria C. N. , Muotri Alysson R. , Griswold Michael D. , Ye Ping , Bortvin Alex , Gage Fred H. , Boeke Jef D. , An Wenfeng 
Published: July 2017

Significance
Retrotransposons make up the bulk of the human genome and, if unleashed, threaten the genomic integrity through DNA damage and insertional mutagenesis. In germ cells, an intact PIWI-interacting RNA pathway is essential for suppressing the expression of L1 retrotransposons. Deficiencies in the PIWI-interacting RNA pathway have dire consequences because mutant males are invariably sterile. To address the role of retrotransposon activation in these mutants, we developed an L1 reporter transgenic mouse. This mouse model allowed us to detect significant and stage-specific increases of new insertions in mutant germ cells, to draw attention to the importance of other L1-related activities for germ-cell health, and to predict the timing and origin of heritable L1 insertions in the human population.
The case for defined protein folding pathways
Authors: Englander S. Walter , Mayne Leland 
Published: July 2017

Significance
This paper considers the experimental evidence for and against the two major current models for protein folding, the theoretically hypothesized many-pathway model, and the experiment-based defined-pathway model. The questions of how proteins fold, why they fold in that way, and how the folding pathway of each protein is encoded in its sequence and structure have fundamental significance for protein structure and design, folding and misfolding, regulation and function, clinical problems, and industrial applications. The present analysis attempts to distinguish the models and answer these questions.
Corruption, financial development and capital structure: evidence from China
Authors: Wei Feng , Kong Yu 
Published: July 2017

Purpose
This paper takes listed companies in the Shanghai and Shenzhen stock markets from 1998 to 2013 as a research sample, investigating the role played by corruption and financial development, along with the interactions between the two, in determining the factors of a company’s capital structure in China’s legal environment. The paper aims to discuss these issues.

Design/methodology/approach
Using data of listed companies and the regional level of China during 1998-2013 and the STATA process (xtabond2 command) developed by Roodman (2006) to implement the two-step GMM estimation, empirically investigate the effect of interactions between corruption and financial development on a company’s capital structure in Chinese legal environment.

Findings
After both controlling for China’s legal environment, a company’s internal factors, and industry factors and considering endogeneity problems, the results show that corruption and financial development have significant positive influences on a company’s bank loans. However, when investigating the interactions between corruption and financial development, the authors find that financial development does not increase a company’s bank loans in areas with a higher level of corruption. However, corruption and financial development have insignificant influences on a company’s long-term bank loans.

Research limitations/implications
The findings in this study suggest that a company’s capital structure was affected not only by the company’s internal factors and industry factors, but also by the company’s external factors, and the interactions between these factors.

Practical implications
To improve the financing circumstances of company credit, the next point of reform should be to improve their procedures for administrative examination and approval of bank creditors and strengthen the punishment and prevention of credit and judicial corruption to weaken the negative effects of corruption on firms’ capital structure decisions.

Originality/value
This study uses only Chinese listed companies, and considers the influence of the interaction of corruption and financial development on a company’s capital structure decisions.
Digital preservation of law reviews: Two ways
Authors: Craigle Valeri 
Published: July 2017

Purpose
This paper will aim to explain two strategies for digital preservation of law reviews, informing law librarians of the options which might best suit their needs.

Design/methodology/approach
On November 7, 2008, the Durham Statement on Open Access to Legal Scholarship was released to the public. One of its main tenets – that law schools and libraries “stop publishing journals in print format and rely instead on electronic publication coupled with a commitment to keep the electronic versions available in stable, open, digital formats” – was an open call to law libraries to start thinking about digital preservation strategies for their law reviews. The Legal Information Preservation Alliance responded to the need by developing the Law Review Preservation Program, an initiative, which archives law reviews hosted on the Bepress Digital Commons (DC) platform in Controlled LOCKSS (Lots of Copies Keep Stuff Safe) or CLOCKSS.

Findings
For those law libraries without subscriptions to DC, there is an open-source, freely available alternative solution for ingesting digital law reviews into any preservation platform. This application, called the Submission Information Metadata Packaging, or SIMP tool was developed at the J. Willard Marriott Library at the University of Utah, initially as a solution for ingesting content into the Ex Libris Rosetta Digital preservation platform, as part of a CONTENTdm digital asset management workflow. Though the development of the SIMP tool was inspired by Marriott’s need to ingest digital files from CONTENTdm to Rosetta, they built it to work with any Digital Asset Management System and Digital preservation platform.

Originality/value
Digital Preservation of law reviews is in its infancy. This is one of the first articles of its kind to provide specific solutions and technical advice for law libraries.
Does post-migration education improve labour market performance? Findings from four cities in Indonesia
Authors: Pratomo Devanto Shasta 
Published: July 2017

Purpose
The purpose of this paper is twofold: first, to examine which factors are important in determining the post-migration education among rural-urban migrants in Indonesia. Second, to investigate whether investing in post-migration education in the cities improves the labour market performances of rural-urban migrants. The labour market performances are measured by the occupational (work) statuses and earnings (wages) at destination.

Design/methodology/approach
The determinants of post-migration education are estimated using a binary probit and ordinary least square, while a multinomial logit model and a two-step procedure of Lee’s selection-biased correction based on the multinomial logit are used to examine the effects of post-migration education on the labour market performances of migrants measured by occupational status and by wages. The main source of the data used in this study is the Rural-Urban Migration in China and Indonesia (RUMiCI) 2009-2011 survey conducted in the four largest recent migrant destination cities in Indonesia including Tangerang, Medan, Samarinda, and Makassar.

Findings
Post-migration education contributes significantly to the labour market performance in terms of work status and wages, compared to pre-migration education. In terms of work status, migrants with more post-migration education are more likely to be employed in the formal sector compared to migrants with less or no post-migration education. Relating to earnings, migrants with more post-migration education also tend to be paid more than those migrants with less or no post-migration education.

Originality/value
The role of post-migration education in the case of rural-urban migration particularly in developing countries is a relatively neglected area of research. One possible reason is because of the lack of data for rural-urban migration particularly in the case of developing countries. This study is taking advantage by using a new data set from RUMiCI focusing specifically on the rural-urban migrants in the four largest recent migrant destination cities in Indonesia including Tangerang, Medan, Samarinda, and Makassar.
Regional dynamism between social and commercial ventures
Authors: Kachlami Habib 
Published: July 2017

PurposeThe purpose of this paper is to study the interaction between social and commercial ventures in a region. It achieves this objective through investigating the influence of social ventures’ entry, exit and density on the entry rate of commercial ventures.Design/methodology/approachOrganizational ecology is applied for theoretical analysis and the feasible generalized least square method for empirical analysis.FindingsThe study, in overall, finds a diffuse competition between the populations of social and commercial ventures. The results have revealed a negative influence of social ventures’ entry and density on the entry rate of commercial ventures and a positive influence of the social ventures’ exit on commercial ventures’ entry rate in a region.Originality/valueThe study is one of the few in its filed that empirically studies the interaction between social and commercial ventures and the first study, which investigates it in the context of Sweden. The previous two studies, however, have only examined either the influence of social ventures entry or social venture density on the entry rate of commercial ventures. This study, however, examines the influence of both of those factors plus the influence of social venture exit on commercial venture entry. The study is also unique regarding the large-scale database it uses including all the 290 municipalities all over Sweden 1990-2014.
Straight from the heart – a clinical group intervention to research management spirituality
Authors: Lychnell Lasse , Mårtensson Pär 
Published: July 2017

Purpose
The purpose of this paper is to contribute to the advancement of research methods in management spirituality by proposing a novel and innovative approach for generating empirical material on issues relevant for practitioners.

Design/methodology/approach
The approach introduced is designed as a one-year group process based on Schein’s concept of clinical inquiry, primarily aimed at helping the participating managers to address challenging issues that they face in real life. When this helping process is successful, empirical material on these issues is revealed, as the participants share information to receive help themselves.

Findings
Findings illustrate how the approach generates extensive, rich and broad data, guided by what becomes important for the participating managers as the process unfolds. A strong holding environment allows for urgent matters to be shared straight from the heart.

Research limitations/implications
As this activity is based on the belief that the managers know best the issues relevant to them, a deviation from the assumed research direction should be seen as help to focus on relevant issues, rather than an obstacle of following an original plan.

Practical implications
The proposed approach may be of particular interest to researchers who not only want to contribute to academic knowledge but also wish to work with people and facilitate transformation.

Originality/value
This paper advances understandings of generating empirical material in the field of management spirituality through an innovative, client-centered research approach, rooted in well-established theories.