bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different implications of the dorsal and ventral hippocampus on contextual memory retrieval after stress
Authors: Pierard C. , Dorey R. , Henkous N. , Mons N. , Béracochéa D. 
Published: June 2017

AbstractThis study assessed the relative contributions of dorsal (dHPC) and ventral (vHPC) hippocampus regions in mediating the rapid effects of an acute stress on contextual memory retrieval. Indeed, we previously showed that an acute stress (3 electric footschocks; 0.9 mA each) delivered 15 min before the 24 h‐test inversed the memory retrieval pattern in a contextual discrimination task. Specifically, mice learned in a four‐hole board two successive discriminations (D1 and D2) varying by the color and texture of the floor. Twenty‐four hours later, nonstressed animals remembered accurately D1 but not D2 whereas stressed mice showed an opposite memory retrieval pattern, D2 being more accurately remembered than D1. We showed here that, at the time of memory testing in that task, stressed animals exhibited no significant changes neither in pCREB activity nor in the time‐course evolution of corticosterone into the vHPC; in contrast, a significant decrease in pCREB activity and a significant increase in corticosterone were observed in the dHPC as compared to nonstressed mice. Moreover, local infusion of the anesthetic lidocaine into the vHPC 15 min before the onset of the stressor did not modify the memory retrieval pattern in nonstress and stress conditions whereas lidocaine infusion into the dHPC induced in nonstressed mice an memory retrieval pattern similar to that observed in stressed animals. The overall set of data shows that memory retrieval in nonstress condition involved primarily the dHPC and that the inversion of memory retrieval pattern after stress is linked to a dHPC but not vHPC dysfunction.
Anatomy of a decision II: Potential effects of changes to Tier I chemical approaches in Canadian Disposal at Sea program sediment assessment protocols
Authors: Apitz Sabine E , Agius Suzanne 
Published: June 2017

Abstract

The effects of possible changes to the Canadian 2-tiered assessment framework for dredged material based on outcomes of the 2006 Contaminated Dredged Material Management Decisions Workshop (CDMMD) are evaluated. Expanding on the “data mining” approach described in a previous paper, which focused solely on chemical lines of evidence, the efficacy of Tier 1 approaches (increases to the number of chemical analytes, use of mean hazard quotients, and the use of a screening bioassay) in predicting toxicity are evaluated. Results suggest value in additional work to evaluate the following areas: 1) further expanding minimum chemical requirements, 2) using more advanced approaches for chemical interpretation, and 3) using a screening-level bioassay (e.g., Canadian solid-phase photoluminescent bacteria test) to determine whether it would complement Tier 1 chemistry as well as or better than the solvent-based Microtox™ test method evaluated in the present study. Integr Environ Assess Manag 2017;13:1072–1085. © 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC)

Key Points
We developed a sediment database to examine international dredged material assessment approaches. A longer chemical action list is more effective at predicting toxicity. Well-designed mean hazard quotient approaches outperform “one out/all out” rules. A conservative Tier 1 screening bioassessment improved toxic detection.
Klotho Lacks an FGF23-Independent Role in Mineral Homeostasis
Authors: Andrukhova Olena , Bayer Jessica , Schüler Christiane , Zeitz Ute , Murali Sathish K , Ada Sibel , Alvarez-Pez Jose M , Smorodchenko Alina , Erben Reinhold G 
Published: June 2017

ABSTRACT

Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating vitamin D hormone production and renal handling of minerals by signaling through an FGF receptor/αKlotho (Klotho) receptor complex. Whether Klotho has FGF23-independent effects on mineral homeostasis is a controversial issue. Here, we aimed to shed more light on this controversy by comparing male and female triple knockout mice with simultaneous deficiency in Fgf23 and Klotho and a nonfunctioning vitamin D receptor (VDR) (Fgf23/Klotho/VDR) with double (Fgf23/VDR, Klotho/VDR, and Fgf23/Klotho) and single Fgf23, Klotho, and VDR mutants. As expected, 4-week-old Fgf23, Klotho, and Fgf23/Klotho knockout mice were hypercalcemic and hyperphosphatemic, whereas VDR, Fgf23/VDR, and Klotho/VDR mice on rescue diet were normocalcemic and normophosphatemic. Serum levels of calcium, phosphate, and sodium did not differ between 4-week-old triple Fgf23/Klotho/VDR and double Fgf23/VDR or Klotho/VDR knockout mice. Notably, 3-month-old Fgf23/Klotho/VDR triple knockout mice were indistinguishable from double Fgf23/VDR and Klotho/VDR compound mutants in terms of serum calcium, serum phosphate, serum sodium, and serum PTH, as well as urinary calcium and sodium excretion. Protein expression analysis revealed increased membrane abundance of sodium-phosphate co-transporter 2a (NaPi-2a), and decreased expression of sodium-chloride co-transporter (NCC) and transient receptor potential cation channel subfamily V member 5 (TRPV5) in Fgf23/Klotho/VDR, Fgf23/VDR, and Klotho/VDR mice, relative to wild-type and VDR mice, but no differences between triple and double knockouts. Further, ex vivo treatment of live kidney slices isolated from wild-type and Klotho/VDR mice with soluble Klotho did not induce changes in intracellular phosphate, calcium or sodium accumulation assessed by two-photon microscopy. In conclusion, our data suggest that the main physiological function of Klotho for mineral homeostasis in vivo is its role as co-receptor mediating Fgf23 action. © 2017 American Society for Bone and Mineral Research.
DJ‐1 Alleviates Angiotensin II‐Induced Endothelial Progenitor Cell Damage by Activating the PPARγ/HO‐1 Pathway
Authors: Han Tao , Liu Meihan , Yang Songbai 
Published: June 2017

ABSTRACTThere is evidence that angiotensin II (Ang II) may impair the functions of endothelial progenitor cells (EPCs). It was revealed that DJ‐1 could resist oxidative stress. In this study, we investigated whether DJ‐1 could protect EPCs against Ang II‐induced cell damage. The proliferation and migration of EPCs were strongly reduced in the Ang II group and were increased by overexpression of DJ‐1. Western blotting indicated that the increased expression of the senescence marker β‐galactosidase and decreased expression of adhesion molecules (ICAM‐1, VCAM‐1) induced by Ang II were reversed after Ad‐DJ‐1 transfection. The reduced angiogenic capacity of EPCs caused by Ang II was also improved after Ad‐DJ‐1 transfection. Moreover, Ang II significantly increased the levels of reactive oxygen species (ROS), malondialdehyde (MDA), and inflammatory cytokines (TNF‐α and IL‐1β), reduced the levels of superoxide dismutase (SOD), glutathione (GSH), and these were reversed by Ad‐DJ‐1 transfection. Expression of peroxisome proliferator‐activated receptor‐γ (PPARγ) and heme oxygenase (HO‐1) was increased by DJ‐1. Therefore, HO‐1 siRNA were constructed and transfected into EPCs, and the results showed that HO‐1 siRNA transfection inhibited the effects of DJ‐1 on EPC function. Thus, our study implies that DJ‐1 may protect EPCs against Ang II‐induced dysfunction by activating the PPARγ/HO‐1. J. Cell. Biochem. 119: 392–400, 2018. © 2017 Wiley Periodicals, Inc.
The Role of Epigenetic Regulation and Pluripotency‐Related MicroRNAs in Differentiation of Pancreatic Stem Cells to Beta Cells
Authors: Coskun Ediz , Ercin Merve , Gezginci‐Oktayoglu Selda 
Published: June 2017

ABSTRACTIn this study, we aimed to research the effects of class‐I HDACs and glucose on differentiation of pancreatic islet derived mesenchymal stem cells (PI‐MSCs) to beta cells. Beta cell differentiation determined by flow cytometric analysis and gene expression levels of PDX1, PAX4, PAX6, NKX6.1, NGN3, INS2, and GLUT2. As a result the valproic acid, is an inhibitor of class‐I HDACs, caused the highest beta cell differentiation in PI‐MSCs. However, the cells in this group were at early stages of differentiation. Glucose co‐administration to this group carried the differentiation to higher levels, but these newly formed beta cells were not functional. Moreover, reduction in the levels of pluripotency factors that Oct3/4, c‐Myc, and Nanog were parallel to beta cell differentiation. Also, the levels of HDAC1 and acetylated H3/H4 were increased and methylated H3 was decreased by VPA treatment. In addition, we have detected over expression in genes of miR‐18a‐5p, miR‐19b‐5p, miR‐30d‐3p, miR‐124, miR‐146a‐5p, miR‐184, miR‐335, and miR‐433‐5p in parallel to beta cell differentiation. As the conclusion, this study is important for understanding the epigenetic mechanism that controls the beta cell differentation and it suggests new molecules that can be used for diagnosis, and treatment of diabetes. J. Cell. Biochem. 119: 455–467, 2018. © 2017 Wiley Periodicals, Inc.
“In‐loop” [11C]CO2 fixation: Prototype and proof of concept
Authors: Dahl Kenneth , Collier Thomas L. , Cheng Ran , Zhang Xiaofei , Sadovski Oleg , Liang Steven H. , Vasdev Neil 
Published: June 2017

Carbon‐11‐labeled carbon dioxide is the most common feedstock for the synthesis of positron emission tomography radiotracers and can be directly used for 11C‐carbonylation. Herein, we report the development of an apparatus that takes advantage of “in‐loop” technologies to facilitate robust and reproducible syntheses of 11C‐carbonyl‐based radiotracers by [11C]CO2‐fixation. Our “in‐loop” [11C]CO2‐fixation method is simple, efficient, and proceeds smoothly at ambient pressure and temperature. We selected model 11C‐carbonyl‐labeled carbamates as well as symmetrical and unsymmetrical ureas based on their widespread use in radiotracer design and our clinical research interests for proof of concept. Utility of this method is demonstrated by the synthesis of a reversible radiopharmaceutical for monoamine oxidase B, [11C]SL25.1188, and 2 novel fatty acid amide hydrolase inhibitors. These radiotracers were isolated and formulated (>3.5 GBq; 100 mCi) with radiochemical purities (>99%) and molar radioactivity (≥80 GBq/μmol; ≥2162 mCi/μmol).
Intratumor cisplatin nephrotoxicity in combined laser‐induced thermal therapy for cancer treatment
Authors: Palumbo Marcel N. , Cervantes Onivaldo , Eugênio Cecilia , Hortense Flávia T. P. , Ribeiro João C. , Paolini Ana Amélia P. , Tedesco Antônio C. , Sercarz Joel A. , Paiva Marcos B. 
Published: June 2017

IntroductionThermal ablation of tumors by Nd:YAG laser has been growing as a multidisciplinary subspecialty defined as laser‐induced thermal therapy (LITT), and has been increasingly accepted as a minimally invasive method for palliation of advanced or recurrent cancer. Previous studies have shown that adjuvant chemotherapy can potentiate laser thermal ablation of tumors leading to improved palliation in advanced cancer patients.ObjectiveEvaluate nephrotoxicity by early markers of renal function in treating head and neck cancer using intra‐tumor injections of cisplatin combined with laser‐induced thermal therapy (CDDP‐LITT).MethodsNine patients with recurrent head and neck tumors were treated by CDDP‐LITT in order to determine nephrotoxicity related to this synergistic association. Among the tests requested to detect early were creatinine, magnesium, creatinine clearance, serum urea‐BUN, type I urine, and proteinuria at 24 hours.ResultsTwelve recurrent tumors in nine patients were treated by CDDP‐LITT. Pain was the major complaint (four patients), while other symptoms included dysphagia, dyspnea, bleeding, and difficulties in chewing. Fifteen laser procedures were performed and maximal CDDP dose was 50 mg. None of the markers for nephrotoxicity showed changes at these levels of CDDP intra‐tumor injections.ConclusionThis initial experience with (CDDP‐LITT) indicates both safety and therapeutic potential for palliation of advanced head and neck cancer. However, safety and feasibility must be confirmed by longer follow‐up and further escalation of CDDP doses in a Phase I study to determine maximum tolerated dose (MTD) and demonstrate tangible benefits for patients. Lasers Surg. Med. 49:756–762, 2017. © 2017 Wiley Periodicals, Inc.
Consumer self‐construal and trust as determinants of the reactance to a recommender advice
Authors: Aljukhadar Muhammad , Trifts Valerie , Senecal Sylvain 
Published: June 2017

AbstractCommercial recommendation agents (RAs) represent an important type of the decision support systems (DSSs) that are widely used by online retailers and firms. To date, little is known about the factors that shape the user's decision making and reactance toward the recommendations of these agents. Building on theories from psychology and information systems domains, this research proposes that a user's self‐construal and trust are two relevant factors that interact to shape the behavior toward the RA advice. Two studies, the first conducted using potential online customers and the second conducted at a behavioral laboratory, provided support to this proposition. The first study considered RA trust and showed that activating the interdependent self leads users with low (high) trust to exhibit high reactance behavior toward the RA advice. The second study variated trust using trust cues and corroborated the latter finding, while showing no important impact for the psychological reactance trait. As expected, in both studies the reactance behavior of independent users was not affected by trust. These results contribute by underscoring that social interdependence extends to RAs because the role of trust becomes salient when the interdependent self is activated for a user.
Under the sway of a mobile device during an in‐store shopping experience
Authors: Rippé Cindy B. , Weisfeld‐Spolter Suri , Yurova Yuliya , Dubinsky Alan J. , Hale Dena 
Published: June 2017

AbstractMobile device technology is transforming the retail shopping experience. Today's consumers are mobile dependent, preferring to consult with their phone, instead of using the salesperson, while shopping at the retail store. In the absence of literature investigating how the salesperson might sell to this omni‐channel, mobile‐connected consumer, this paper proposes a conceptual model and tests its proposed linkages. The empirically tested model presents a dyadic view of the omni‐channel consumer and the salesperson. Uniquely contributing to the omni‐channel and marketing literature, samples from an emerging economy (India) and developed (United States) economy represent the contexts. Specifically, the research examines the salesperson's role in selling to a mobile‐dependent consumer who uses mobile technology to search for information during the sales meeting. Findings show that adaptive selling can affect purchase intention and customer predisposition to comply with salesperson input. Results also reveal how perceived control, mobile dependence, and customer predisposition to comply with mobile device input affect purchase intention. Managerial and research implications specifically appropriate for the omni‐consumer retail setting are offered.
Can preoperative detrusor underactivity influence surgical outcomes of 120 W HPS vaporization of the prostate (PVP) or holmium laser enucleation of the prostate (HoLEP)? A serial 3‐year follow‐up study
Authors: Cho Min Chul , Park Juhyun , Kim Jung Kwon , Cho Sung Yong , Jeong Hyeon , Oh Seung‐June , Paick Jae‐Seung , Son Hwancheol 
Published: June 2017

AimsTo determine the influence of preoperative detrusor underactivity (DU) on serial long‐term outcomes of HPS/PVP or HoLEP for LUTS/BPH, and to compare the influence between the two surgeries.MethodsA total of 382 men, who underwent 120W‐HPS/PVP or HoLEP for LUTS/BPH and for whom 36‐month follow‐up data were available, were classified into four groups: HPS with DU (n = 145), HPS without DU (n = 44), HoLEP with DU (n = 105), and HoLEP without DU (n = 88). DU was defined as bladder contractility index of <100. Surgical outcomes were assessed at postoperative 6, 12, 24, and 36 months using IPSS, uroflowmetry, and serum PSA.ResultsAll four groups maintained improvements in voiding symptom score (VSS), storage symptom score, total‐IPSS, QOL index, maximum flow rate (Qmax), post‐void residual urine volume (PVR), and bladder voiding efficiency (BVE) compared with baseline up to 3 years postoperatively. There were no significant differences in improvements of postoperative IPSS parameters including QOL index between men with and without DU throughout the follow‐up period after HPS or HoLEP. In men with DU, there were no significant differences in improvements of postoperative QOL index, Qmax, PVR, or BVE between HPS and HoLEP groups throughout the follow‐up period, except for VSS and total IPSS. Serum PSA reductions after HoLEP were greater than after PVP.ConclusionsImprovements in LUTS, Qmax, and BVE can maintain up to 3 years after HPS or HoLEP for LUTS/BPH, irrespective of the presence or absence of preoperative DU. Although HoLEP may provide more durable improvement of VS in men with DU than HPS, there seems to be no difference in improvement of QOL or Qmax or BVE between HPS and HoLEP.
The Dietary Intervention to Enhance Tracking with Mobile Devices (DIET Mobile) Study: A 6‐Month Randomized Weight Loss Trial
Authors: Turner‐McGrievy Gabrielle M. , Wilcox Sara , Boutté Alycia , Hutto Brent E. , Singletary Camelia , Muth Eric R. , Hoover Adam W. 
Published: June 2017

ObjectiveTo examine the use of two different mobile dietary self‐monitoring methods for weight loss.MethodsAdults with overweight (n = 81; mean BMI 34.7 ± 5.6 kg/m2) were randomized to self‐monitor their diet with a mobile app (App, n = 42) or wearable Bite Counter device (Bite, n = 39). Both groups received the same behavioral weight loss information via twice‐weekly podcasts. Weight, physical activity (International Physical Activity Questionnaire), and energy intake (two dietary recalls) were assessed at 0, 3, and 6 months.ResultsAt 6 months, 75% of participants completed the trial. The App group lost significantly more weight (−6.8 ± 0.8 kg) than the Bite group (−3.0 ± 0.8 kg; group × time interaction: P < 0.001). Changes in energy intake (kcal/d) (−621 ± 157 App, −456 ± 167 Bite; P = 0.47) or number of days diet was tracked (90.7 ± 9.1 App, 68.4 ± 9.8 Bite; P = 0.09) did not differ between groups, but the Bite group had significant increases in physical activity metabolic equivalents (+2015.4 ± 684.6 min/wk; P = 0.02) compared to little change in the App group (−136.5 ± 630.6; P = 0.02). Total weight loss was significantly correlated with number of podcasts downloaded (r = −0.33, P < 0.01) and number of days diet was tracked (r = −0.33, P < 0.01).ConclusionsWhile frequency of diet tracking was similar between the App and Bite groups, there was greater weight loss observed in the App group.
Factors possibly affecting prognosis in children with Wilms’ tumor diagnosed before 24 months of age: A report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) Wilms Tumor Working Group
Authors: D'Angelo Paolo , Di Cataldo Andrea , Terenziani Monica , Bisogno Gianni , Collini Paola , Di Martino Martina , Melchionda Fraia , Mosa Clara , Nantron Marilina , Perotti Daniela , Puccio Giuseppe , Serra Annalisa , Catania Serena , Spreafico Filippo ,   for the AIEOP Wilms Tumor Working Group
Published: June 2017

AbstractBackgroundChildren with Wilms’ tumor (WT) aged under 24 months (infants) have a better prognosis than older patients. Our aim was to study the epidemiology of this age group, with focus on the modality of diagnosis, tumor size, and association with malformations/syndromes, seeking to understand if any of these factors might be related to prognosis.Patients and methodsInfants diagnosed with WT between 2003 and February 2010 were evaluated. A query form was used to collect data on the modality of WT diagnosis (symptomatic or incidental), tumor volume, maximum diameter, site, and stage.ResultsData were collected for 117 of 124 WT infants registered. Twenty‐four cases had an incidental diagnosis (ID) of renal mass, usually arising from an abdominal ultrasound performed for other reasons, and 93 had been diagnosed based on clinical signs/symptoms. The incidental cohort displayed unifocal disease, mean tumor diameter 5.52 cm, mean tumor volume 84.30 ml, and 14 patients showed associated malformations. Symptomatic patients had mean maximum tumor diameter of 10.18 cm, mean tumor volume of 451.18 ml, and six had associated malformations.ConclusionsOur study showed that 20% of the infants had an ID of WT; they had a relatively smaller nonmetastatic tumor and a higher rate of malformations than infants of the symptomatically diagnosed group, but we did not detect any difference in age at diagnosis between the two groups. Conversely, we found a significant difference in the 5‐year event‐free survival rate (P = 0.018) between infants under 1 year (96%), more frequently associated with congenital malformations, and infants 1–2 years (80%).
Hospitalization rate and costs in acute lymphoblastic leukemia of childhood in a low‐income group: Financial impact in Northeast Mexico
Authors: Jaime‐Pérez José Carlos , Fernández Lucía Teresa , Jiménez‐Castillo Raúl Alberto , Colunga‐Pedraza Julia Esther , Padilla‐Medina José Ramón , Mancías‐Guerra Consuelo , Gómez‐Almaguer David 
Published: June 2017

AbstractBackgroundAcute lymphoblastic leukemia (ALL) is one of the main and most expensive and prolonged causes of hospitalization for childhood cancer. We describe the hospitalization rate and its costs for an open population with ALL in a low‐middle income country.ProcedureWe retrospectively analyzed 449 hospital admissions for 101 pediatric patients with ALL over 8 years. Clinical files and electronic databases were scrutinized to document causes, duration, readmission rate, costs, and outcome of each admission. Hospitalizations were divided into two categories: general pediatric ward and pediatric intensive care unit (PICU). Hospitalization rates and its costs per patient were estimated considering person‐time at risk.ResultsPatients had an admission rate of 2.09 hospitalizations per patient‐year and median length of stay per admission was 5 days. Most admissions occurred during the first 2 years from diagnosis. Mean cost per day was 239 US dollars (USD) and mean cost per stay was 2,246 USD versus 1,016 and 19,004 USD (P = 0.001) in the PICU, respectively. Total hospitalization cost per patient per year (PPPY) was 5,991 USD for high‐risk patients and 3,038 USD for standard‐risk patients. Patients between ages 1 and 9 years had a PPPY cost of $4,057; while for children younger than 1 year or older than 9 years, it was 7,463 USD. The popular medical insurance program covered 70% of hospitalizations and 63% of its total cost; patients contributed 2%, with the hospital absorbing 35%.ConclusionsHospitalizations for children with ALL were less expensive than in high‐income countries but had a significant cost to low‐income families and to the healthcare system.