bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of Preexisting Cardiovascular Comorbidities to Newly Diagnosed Atrial Fibrillation After Ischemic Stroke
Authors: Bisson Arnaud , Clementy Nicolas , Bodin Alexandre , Angoulvant Denis , Babuty Dominique , Lip Gregory Y.H. , Fauchier Laurent 
Published: September 2017

Background and Purpose—
There remains uncertainty as whether newly diagnosed atrial fibrillation (AF) after ischemic stroke reflects underlying heart disease and represents an increased risk of cardioembolic stroke, or whether it is triggered by neurogenic mechanisms. We aimed to determine whether cardiovascular comorbidities in patients with new AF after ischemic stroke differ from patients with previous known AF or without AF.

Methods—
This French longitudinal cohort study was based on the database covering hospital care from 2009 to 2012 for the entire population.

Results—

Of 336 291 patients with ischemic stroke, 240 459 (71.5%) had no AF and 95 832 (28.5%) had previously known AF at baseline. Patients without previous AF had a mean CHA
2
DS
2
-VASc score of 4.98±1.63 SD. During a mean follow-up of 7.9±11.5 months, 14 095 (5.9%) of these patients had incident AF, representing an annual incidence of AF after ischemic stroke of 8.9 per 100 person-years (95% confidence interval, 8.8–9.0). New AF patients had higher CHA
2
DS
2
-VASc score, more likely comorbidities, and more frequent history of previous transient ischemic attack than patients with previous known AF or without AF.

Conclusions—
Preexisting cardiovascular comorbidities underlie AF newly diagnosed after stroke. Consequently, these high-risk patients should be closely monitored for incident AF to facilitate an earlier diagnosis of AF and avoid stroke with appropriate thromboprophylaxis.
Parvovirus B19 Infection in Children With Arterial Ischemic Stroke
Authors: Fullerton Heather J. , Luna Jorge M. , Wintermark Max , Hills Nancy K. , Tokarz Rafal , Li Ying , Glaser Carol , DeVeber Gabrielle A. , Lipkin W. Ian , Elkind Mitchell S.V. 
Published: September 2017

Background and Purpose—
Case–control studies suggest that acute infection transiently increases the risk of childhood arterial ischemic stroke. We hypothesized that an unbiased pathogen discovery approach utilizing MassTag–polymerase chain reaction would identify pathogens in the blood of childhood arterial ischemic stroke cases.

Methods—
The multicenter international VIPS study (Vascular Effects of Infection in Pediatric Stroke) enrolled arterial ischemic stroke cases, and stroke-free controls, aged 29 days through 18 years. Parental interview included questions on recent infections. In this pilot study, we used MassTag–polymerase chain reaction to test the plasma of the first 161 cases and 34 controls enrolled for a panel of 28 common bacterial and viral pathogens.

Results—
Pathogen DNA was detected in no controls and 14 cases (8.7%): parvovirus B19 (n=10), herpesvirus 6 (n=2), adenovirus (n=1), and rhinovirus 6C (n=1). Parvovirus B19 infection was confirmed by serologies in all 10; infection was subclinical in 8. Four cases with parvovirus B19 had underlying congenital heart disease, whereas another 5 had a distinct arteriopathy involving a long-segment stenosis of the distal internal carotid and proximal middle cerebral arteries.

Conclusions—
Using MassTag–polymerase chain reaction, we detected parvovirus B19—a virus known to infect erythrocytes and endothelial cells—in some cases of childhood arterial ischemic stroke. This approach can generate new, testable hypotheses about childhood stroke pathogenesis.
The Freedom of Religion or Belief in the echr since Kokkinakis. Or “Quoting Kokkinakis”
Authors: Evans Malcolm 
Published: September 2017

Abstract
The Kokkinakis case is probably the most widely cited judgement of the European Court of Human Rights concerning the freedom of religion or belief. Yet the constant repetition of its key passages tends to obscure the very real, and controversial, developments which have taken place in the Court’s jurisprudence. This article outlines this practice and explores its implications. It concludes that “quoting Kokkinakis” runs the risk of have a negative impact upon our understanding of Article 9 of the echr today and its famous ‘mantra’ should be replaced by a more up to date and accurate statement of the conceptual underpinnings of that article.
Venous Complications in One Versus Two Vein Anastomoses in Head and Neck Free Flaps
Authors: Khaja Sobia F. , Rubin Nathan , Bayon Rodrigo 
Published: September 2017

Objective: The purpose of this study was to compare rates of reexploration and flap failure in patients with 1- and 2-vein anastomoses in free flap reconstructions. Methods: Retrospective chart review of 300 patients undergoing free flap reconstruction to head and neck defects from 2010 to 2014. Results: One venous anastomosis was performed in 229 patients, and 2 venous anastomoses were performed in 71 patients. The 1-vein group had significantly more reexplorations in the operating room (36/229, 15.7%) compared with the 2-vein group (4/71, 5.6%; P = .028), even when controlling for flap type ( P = .022). This finding remained true among radial forearm flaps (17/81, 21% vs 3/53, 5.7%; P = .024). The number of venous anastomoses was not significantly associated with flap failure, though patients with flap failure did have a significantly greater proportion of venous issues ( P < .001). Conclusions: Two-vein anastomoses do not appear to reduce rates of flap failure or postoperative venous thrombosis but are associated with a lower number of reexplorations in the operating room even after accounting for differences in flap types and surgeons.
Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia
Authors: Nakamae Ikuko , Kato Jun-ya , Yokoyama Takashi , Ito Hidenori , Yoneda-Kato Noriko 
Published: September 2017

Abstract
C/EBPα is a key transcription factor regulating myeloid differentiation and leukemogenesis. The Trib1-COP1 complex is an E3 ubiquitin ligase that targets C/EBPα for degradation, and its overexpression specifically induces acute myeloid leukemia (AML). Here we show that myeloid leukemia factor 1 (MLF1) stabilizes C/EBPα protein levels by inhibiting the ligase activity of the Trib1-COP1 complex. MLF1 directly interacts with COP1 in the nucleus and interferes with the formation of the Trib1-COP1 complex, thereby blocking its ability to polyubiquitinate C/EBPα for degradation. MLF1 overexpression suppressed the Trib1-induced growth advantage in a murine bone marrow (BM) culture and Trib1-induced AML development in BM-transplanted mouse models. MLF1 was expressed in hematopoietic stem cells and myeloid progenitors (common myeloid progenitors and granulocyte-macrophage progenitors) in normal hematopoiesis, which is consistent with the distribution of C/EBPα. An MLF1 deficiency conferred a more immature phenotype on Trib1-induced AML development. A higher expression ratio of Trib1 to MLF1 was a key determinant for AML development in mouse models, which was also confirmed in human patient samples with acute leukemia. These results indicate that MLF1 is a positive regulator that is critical for C/EBPα stability in the early phases of hematopoiesis and leukemogenesis.
Genome sequence of the sulfur-oxidizing Bathymodiolus thermophilus gill endosymbiont
Authors: Ponnudurai Ruby , Sayavedra Lizbeth , Kleiner Manuel , Heiden Stefan E. , Thürmer Andrea , Felbeck Horst , Schlüter Rabea , Sievert Stefan M. , Daniel Rolf , Schweder Thomas , Markert Stephanie 
Published: September 2017

AbstractBathymodiolus thermophilus, a mytilid mussel inhabiting the deep-sea hydrothermal vents of the East Pacific Rise, lives in symbiosis with chemosynthetic Gammaproteobacteria within its gills. The intracellular symbiont population synthesizes nutrients for the bivalve host using the reduced sulfur compounds emanating from the vents as energy source. As the symbiont is uncultured, comprehensive and detailed insights into its metabolism and its interactions with the host can only be obtained from culture-independent approaches such as genomics and proteomics. In this study, we report the first draft genome sequence of the sulfur-oxidizing symbiont of B. thermophilus, here tentatively named Candidatus Thioglobus thermophilus. The draft genome (3.1 Mb) harbors 3045 protein-coding genes. It revealed pathways for the use of sulfide and thiosulfate as energy sources and encodes the Calvin-Benson-Bassham cycle for CO2 fixation. Enzymes required for the synthesis of the tricarboxylic acid cycle intermediates oxaloacetate and succinate were absent, suggesting that these intermediates may be substituted by metabolites from external sources. We also detected a repertoire of genes associated with cell surface adhesion, bacteriotoxicity and phage immunity, which may perform symbiosis-specific roles in the B. thermophilus symbiosis.
Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation
Authors: Ichikawa Takafumi , Kita Masahiro , Matsui Tsubasa S. , Nagasato Ayaka Ichikawa , Araki Tomohiko , Chiang Shian-Huey , Sezaki Takuhito , Kimura Yasuhisa , Ueda Kazumitsu , Deguchi Shinji , Saltiel Alan R. , Kioka Noriyuki 
Published: September 2017

ABSTRACT
Vinexin, c-Cbl associated protein (CAP) and Arg-binding protein 2 (ArgBP2) constitute an adaptor protein family called the vinexin (SORBS) family that is targeted to focal adhesions (FAs). Although numerous studies have focused on each of the SORBS proteins and partially elucidated their involvement in mechanotransduction, a comparative analysis of their function has not been well addressed. Here, we established mouse embryonic fibroblasts that individually expressed SORBS proteins and analysed their functions in an identical cell context. Both vinexin-α and CAP co-localized with vinculin at FAs and promoted the appearance of vinculin-rich FAs, whereas ArgBP2 co-localized with α-actinin at the proximal end of FAs and punctate structures on actin stress fibers (SFs), and induced paxillin-rich FAs. Furthermore, both vinexin-α and CAP contributed to extracellular matrix stiffness-dependent vinculin behaviors, while ArgBP2 stabilized α-actinin on SFs and enhanced intracellular contractile forces. These results demonstrate the differential roles of SORBS proteins in mechanotransduction.
The effects of short-term group psychodynamic psychotherapy on the personality traits of patients treated in a day ward
Authors: Sieradzki Adrian , Szechiński Marcin , Małyszczak Krzysztof 
Published: September 2017

Cel pracyDoniesienia z ostatnich lat wskazują na rolę neurotyzmu i ekstrawersji w rozwoju zaburzeń lękowych i depresyjnych. Celem badań była ocena wpływu krótkoterminowej grupowej psychoterapii psychodynamicznej (KGPP) na zachowanie się cech osobowości w populacji osób z zaburzeniami nerwicowymi i osobowości w warunkach oddziału dziennego leczenia nerwic (ODLN).MetodaDo badania zakwalifikowano 139 osób z zaburzeniami lękowymi i osobowości, z których 110 uczestniczyło w pomiarach kontrolnych. Wymiary osobowości (neurotyzm, ekstrawersja, psychotyzm, kłamstwo) oceniano na podstawie zaadaptowanej do warunków polskich wersji kwestionariusza osobowości Eysencka (EPQ). Pomiary przeprowadzano w dwóch punktach czasowych: (1) przed leczeniem, (2) po 12 tygodniach terapii.WynikiWyniki: W grupie osób z zaburzeniami nerwicowymi poziom neurotyzmu, ekstrawersji, psychotyzmu i kłamstwa nie uległ istotnym zmianom w czasie terapii. W grupie osób z zaburzeniami osobowości poziom neurotyzmu uległ istotnej redukcji (p=0,0008), natomiast poziom ekstrawersji uległ zwiększeniu (p=0,037). Wartości cech psychotyzmu i kłamstwa nie uległy znaczącym zmianom w toku psychoterapii w żadnej z grup pacjentów.WnioskiDynamika zmian neurotyzmu i ekstrawersji pod wpływem krótkoterminowej grupowej psychoterapii psychodynamicznej w warunkach ODLN wydaje się istotnym markerem oceny efektywności procesu leczenia dla osób cierpiących na zaburzenia osobowości. W grupie osób z zaburzeniami lękowymi pojawia się potrzeba opracowania bardziej precyzyjnych parametrów oceny zdrowienia.
Rectangular Gusset Plate Behaviour in Cold-Formed I-Type Steel Connections
Authors: Bučmys Ž. , Daniūnas A. 
Published: September 2017

Abstract Cold-formed structure connections utilizing gusset plates are usually semi-rigid. This paper investigates the behaviours of rectangular gusset plates in cold-formed connections of elements whose columns and beams are made with lipped back-to-back C-sections. Methods of calculating strength and stiffness are necessary for such semi-rigid joints. The main task of this paper is to determine a method capable of calculating these characteristics. The proposed analytical method could then be easily adapted to the component method that is described in part 1993-1-8 of the Eurocode. This method allows us to calculate both the strength and stiffness of rectangular gusset plates, assuming that the joint deforms only in plane. This method of design moment resistance calculation was presented taking into account that an entire cross-section shall reach its yield stress. A technique of stiffness calculation was presented investigating the sum of deformations acquired at the bending moment and from shear forces which are transmitted from each beam bolt group. Calculation results according to the suggested method show good agreement of laboratory experimental results of specimens with numerical simulations. Two specimens of beam-to-column connections were tested in the laboratory. Lateral supports were used on the specimens to prevent lateral displacements in order to better investigate the behaviour of the rectangular gusset plate in plane. Experiments were simulated by modelling rectangular gusset plates using standard finite element software ANSYS Workbench 14.0. Three-dimensional solid elements were used for modelling and both geometric and material nonlinear analysis was performed.
Quantitative Assessment of Construction Risk
Authors: Kasprowicz T. 
Published: September 2017

Abstract Construction risk assessment is the final and decisive stage of risk analysis. When highly changeable conditions of works execution are predicted, risk should be evaluated in the favorable, moderate, and difficult random conditions of construction. Given the random conditions, the schedule and cost estimate of the construction are developed. Based on these values, the risk of final deadline delay and the risk of total cost increase of construction completion are calculated. Next, the charts of the risks are elaborated. Risk changes are shown in the charts and are analyzed in the range [1, 0].
Bond Between Steel and Self-Compacting Concrete in Composite Tube Columns
Authors: Szadkowska M. , Szmigiera E. 
Published: September 2017

Abstract This paper presents research results of composite tubes filled with self-compacting concrete. The impact of the selected materials and geometric factors on resistance to the vertical shear was evaluated in this study. The resistance of the tested members was compared with recommendations given in Eurocode PN-EN 1994-1-1. From the results obtained in the tests it can be deduced that more parameters should be taken into consideration when determining resistance to the vertical shear in the interface between steel and concrete than PN-EN 1994- 1-1 recommends.
Expert Cause and Effect Analysis of the Failure of Historical Structures Taking Into Account Factors That are Difficult to Measure
Authors: Śladowski G. , Paruch R. 
Published: September 2017

Abstract The protection of Polish architectural heritage in the former eastern borderlands, accomplished through the conservation and technical securing of historical structures, constitutes one of the main programmes that are implemented by the Ministry of Culture and National Heritage. Currently, many Polish historical buildings in the former eastern borderlands are in a very bad technical condition. The load-bearing systems of these elements, as well as elements of their finish, require immediate emergency securing work. The basic steps that precede conservation work are emergency structural works, which guarantee the durability and stability of the entire historical substance. The specifics and complexity of the problem of the failure of historical buildings often demands an in-depth analysis of a series of factors that are difficult to measure and which are responsible for the cause and effect relationship during the early stage of the technical evaluation of a structure. The analyses of failures of numerous historical structures, for instance that were carried out by the authors, have become the inspiration for the search for effective methods of analysis that would allow for an in-depth analysis of the causes and effects of the failures in question. The DEMATEL method (Decision Making Trial and Evaluation Laboratory) that has been presented in this work, and its fuzzy extension, has lately become one of the more popular methods used in the cause-and-effect analysis of various phenomena. The authors demonstrated how this method works on the example of the evaluation and securing of the load-bearing system of the XVII Collegiate church of the Holy Trinity in the town of Olykha in the Volhynskiy Oblast, Ukraine.
Some Invariant Properties of Quasi-Möbius Maps
Authors: Heer Loreno 
Published: September 2017

AbstractWe investigate properties which remain invariant under the action of quasi-Möbius maps of quasimetric spaces. A metric space is called doubling with constant D if every ball of finite radius can be covered by at most D balls of half the radius. It is shown that the doubling property is an invariant property for (quasi-)Möbius maps. Additionally it is shown that the property of uniform disconnectedness is an invariant for (quasi-)Möbius maps as well.
A Diffusion Equation with a Variable Reaction Order
Authors: García-Melián Jorge , Rossi Julio D. , Sabina de Lis José C. 
Published: September 2017

Abstract
This paper deals with the problem

{

-

Δ
⁢
u

=

λ
⁢

u

q
⁢

(
x
)

,

x

∈
Ω

,

u

=
0

,

x

∈

∂
⁡
Ω

,

\left\{\begin{aligned} \displaystyle-\Delta u&\displaystyle=\lambda u^{q(x)},&% \hskip 10.0ptx&\displaystyle\in\Omega,\\ \displaystyle u&\displaystyle=0,&\hskip 10.0ptx&\displaystyle\in\partial\Omega% ,\end{aligned}\right.

where

Ω
⊂

ℝ
N

{\Omega\subset\mathbb{R}^{N}}

is a bounded smooth domain,

λ
>
0

{\lambda>0}

is a parameter and the reaction order

q
⁢

(
x
)

{q(x)}

is a Hölder continuous positive function satisfying

q
⁢

(
x
)

>
1

{q(x)>1}

for all

x
∈
Ω

{x\in\Omega}

. The relevant feature here is that q is assumed to achieve the value one on

∂
⁡
Ω

{\partial\Omega}

. By assuming that q is subcritical, our main result states the existence of a positive solution for all

λ
>
0

{\lambda>0}

. We also study its asymptotic behavior as

λ
→
0

{\lambda\to 0}

and as

λ
→
∞

{\lambda\to\infty}

. It should be noticed that the fact that

q
=
1

{q=1}

somewhere in

∂
⁡
Ω

{\partial\Omega}

gives rise to serious difficulties when looking for critical points of the functional associated with the problem above. This work is a continuation of [13] where q is assumed to take values both greater and smaller than one in Ω, but is constrained to satisfy

q
⁢

(
x
)

>
1

{q(x)>1}

on

∂
⁡
Ω

{\partial\Omega}

.
Characteristics of sleep disorders in Romanian adults infected with human immunodeficiency virus
Authors: Arbune Manuela , Dumitru Irina-Magdalena , Cretu-Stuparu Mariana 
Published: September 2017

Abstract
Sleep disorders commonly occur in chronic diseases and are a great impairment on the quality of life. The current study aims to characterize the sleep problems of a group of Romanian HIV positive patients. A cross sectional study assessed sleep disorders by a series of self-report questionnaires: STOP-BANG, Epworth Sleep Questionnaire and Pittsburgh Sleep Quality Index. Demographic data, antiretroviral therapy, Lymphocytes CD4 levels were collected from medical records. Exclusion criteria were illiteracy, severe neurocognitive dysfunction and depression. We included 102 patients infected with human immunodeficiency virus, age between 22 and 50, sex ratio M/F=1.17. Reported conditions related to sleep disorders were: smoking (50%), hypertension (18%), obesity (6%) and snoring (7%). The STOP-BANG scale indicated 19% intermediate risk and 2% high risk of sleep apnea. According to Epworth score, daytime sleepiness was found in 18% of patients, 2% of them were dangerously sleepy. The average global score of Pittsburg Sleep Questionnaire is indicative of poor sleep quality in 42% cases. No correlation of sleep scores with antiretroviral regimens was found. Sleep problems with negative impact on daily functioning are frequent under age 50, in patients with human immunodeficiency virus. The management of chronic co-morbidities and psychological support should improve sleep disorders related to human immunodeficiency virus.
Direct odontal restoration with pre-fabricated screw metal post-case report
Authors: Perlea Paula , Gheorghiu Irina-Maria , Ciolan C. G. , Mitran Loredana , Scarlatescu Sanziana , Margarit Ruxandra , Mitran M. 
Published: September 2017

Abstract
We are very often confronted in dental daily practice with the clinical situations where important loss of hard dental structure is present and direct restoration is required. In these cases, armed odontal direct restauration can be performed, using additional retention systems. The restoration of the coronal part in non-vital teeth has certain specific aspects and one of the most used endodontic anchorage is the metal threaded prefabricated posts. Current techniques and materials allow the dentist to fulfill all the clinical requirements, in terms of resistance to occlusal stress and the esthetic aspect of the restoration.