bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Cardiovascular Disease in Individuals With Dysbetalipoproteinemia: A Prospective Study in the UK Biobank
Authors: Paquette Martine , Trinder Mark , Guay Simon-Pierre , Brunham Liam R , Baass Alexis 
Published: September 2024

Abstract

Background
Dysbetalipoproteinemia (DBL) is a disorder of remnant cholesterol metabolism associated with a severe risk of atherosclerotic cardiovascular disease (ASCVD).

Objective
The objective of this study was to investigate the univariate and multivariate predictors of ASCVD in individuals with DBL.

Methods
Data from 2699 individuals with ɛ2/ɛ2 genotypes from the UK Biobank were included in this study. DBL was defined as having an ɛ2ɛ2 genotype with evidence of dyslipidemia, defined as total cholesterol ≥ 200 mg/dL (5.2 mmol/L) and triglyceride ≥ 175 mg/dL (2.0 mmol/L) or lipid-lowering therapy use (n = 964).

Results
Age, hypertension, waist circumference, and a polygenic risk score for coronary artery disease (PRSCAD) were independent predictors of ASCVD among individuals with DBL. Cumulative ASCVD-free survival was lower in the ɛ2/ɛ2 DBL group (84%) compared to the ɛ2/ɛ2 non-DBL group (94%) (P &lt; .0001) and for DBL individuals with a PRSCAD ≥ median (79%) compared to those with a PRSCAD &lt; median (89%) (P = .001).

Conclusion
We show in a large prospective cohort that a PRSCAD predicts the ASCVD risk among individuals with DBL. The findings of the present study highlight the need for better risk stratification in ɛ2/ɛ2 carriers to identify high-risk individuals who would need aggressive cardiovascular management despite their low apolipoprotein B value.
RNA Splicing Events in Circulation Distinguish Individuals With and Without New-onset Type 1 Diabetes
Authors: Webb-Robertson Bobbie-Jo M , Wu Wenting , Flores Javier E , Bramer Lisa M , Syed Farooq , Tersey Sarah A , May Sarah C , Sims Emily K , Evans-Molina Carmella , Mirmira Raghavendra G 
Published: September 2024

Abstract

Context
Alterations in RNA splicing may influence protein isoform diversity that contributes to or reflects the pathophysiology of certain diseases. Whereas specific RNA splicing events in pancreatic islets have been investigated in models of inflammation in vitro, how RNA splicing in the circulation correlates with or is reflective of type 1 diabetes (T1D) disease pathophysiology in humans remains unexplored.

Objective
To use machine learning to investigate if alternative RNA splicing events differ between individuals with and without new-onset T1D and to determine if these splicing events provide insight into T1D pathophysiology.

Methods
RNA deep sequencing was performed on whole blood samples from 2 independent cohorts: a training cohort consisting of 12 individuals with new-onset T1D and 12 age- and sex-matched nondiabetic controls and a validation cohort of the same size and demographics. Machine learning analysis was used to identify specific isoforms that could distinguish individuals with T1D from controls.

Results
Distinct patterns of RNA splicing differentiated participants with T1D from unaffected controls. Notably, certain splicing events, particularly involving retained introns, showed significant association with T1D. Machine learning analysis using these splicing events as features from the training cohort demonstrated high accuracy in distinguishing between T1D subjects and controls in the validation cohort. Gene Ontology pathway enrichment analysis of the retained intron category showed evidence for a systemic viral response in T1D subjects.

Conclusion
Alternative RNA splicing events in whole blood are significantly enriched in individuals with new-onset T1D and can effectively distinguish these individuals from unaffected controls. Our findings also suggest that RNA splicing profiles offer the potential to provide insights into disease pathogenesis.
Komplexität in der Produktion – Herausforderungen durch Über- und Unterforderung
Authors: Brinzer Boris , Schneider Konstanze 
Published: September 2024

Abstract
The growing complexity of production processes coincides with accelerated changes in the environment and the workforce. The negative effects of inadequate complexity in production can be seen at the employee and the process level, and without complexity management they can threaten the existence of the company. A cross-company study with a tested evaluation methodology highlights challenges caused by overcharging or under-challenging complexity levels as well as their effects on employees and processes.
Methodische Entwicklung und Bewertung neuer Fertigungsrouten
Authors: Marker Edgar , Bergner Jan , Holzer Katja , Volk Wolfram , Hartmann Christoph 
Published: September 2024

AbstractWhen developing and evaluating production routes, the focus is often on economic aspects. It is difficult to take qualitative product properties into account as they are difficult to quantify. Using the example of the development of a new production route for the manufacture of large-volume hydrogen pressure vessels, this article presents a methodology that makes it possible to identify new routes and evaluate them according to quantitative and qualitative criteria using a key figure. This should make it easy to compare different production routes.
Rattervermeidung beim Fräsen mit Industrierobotern
Authors: Evers Lasse , Blühm Melchior , Weise Tom , Dege Jan Hendrik 
Published: September 2024

Abstract
The machining of components is usually carried out using specialized machine tools, which shift the stability limit towards high productivity due to their high rigidity and damping. An intelligent design of the end effector promises a positive influence on the stability limit in order to achieve comparable results with more cost-effective industrial robots. This article therefore investigates the influence of different milling spindles and tool concepts on the stability of milling processes on an industrial robot.
Dynamische Kollisionsvermeidung in der Fräsbearbeitung
Authors: Winkler Martin , Denkena Berend 
Published: September 2024

Abstract
Complex milling processes often require extensive preliminary checks in order to avoid collisions between the tool, clamping device and workpiece. The resulting costs can only be allocated to a few workpieces, especially in small series production, and represent a challenge in view of the increasing complexity of product portfolios. This article presents a method for automatic collision avoidance in milling. A process-parallel simulation is coupled directly with the machine tool in order to precisely detect collisions and enable dynamic reactions. The results show that the proposed method could successfully avoid 100 % of provoked collisions and thus can significantly increase the efficiency of machining processes.
The theological vindication of resistance against enforced motherhood
Authors: Nickel Mary 
Published: September 2024

For the suffragists of the 19th century, women’s enfranchisement was a central goal. Yet the right to vote was not nearly as vital to the suffragists as the right to one’s own bodily freedom. Furthermore, as they saw it, bodily autonomy was a ‘sacred’ right: it was grounded theologically. Most concerning to the suffragists were the ways in which women of their time were forced against their will to become mothers. This article presents the suffragists’ theological grounds for resisting enforced motherhood. As I argue, doing so serves three purposes. First, it helps pro-choice Christians understand the ways in which their faith might support the defense of abortion access. Second, it foregrounds the political theological insights of the all too often overlooked suffragists. Finally, and perhaps most importantly, it gives the lie to a widespread mischaracterization of the suffragists as would-be advocates of the contemporary anti-abortion movement.
Clinical Profile of Non-thyroidal Cancer Patients with Tyrosine Kinase Inhibitor-Induced Thyroid Dysfunction in the University of Santo Tomas Hospital, Philippines
Authors: Luna Nenuel Angelo , Quinitio Jennilyn , Mendoza Erick , Kho Sjoberg , Caguioa Priscilla 
Published: September 2024

Objectives. This study aimed to determine the clinical profile of non-thyroidal cancer patients with thyroid dysfunction associated with tyrosine kinase inhibitor (TKI) therapy at the University of Santo Tomas Hospital (USTH), Philippines.
Methodology. This is a retrospective observational study of TKI-initiated adult non-thyroidal cancer patients with thyroid function testing from 2013 to 2018.
Results. Forty percent (95% CI: 26.2% - 58.61%) of the sixty individuals who had thyroid function tests (TFT) had incident thyroid dysfunction. Thirty percent had hypothyroidism (i.e., 25% overt [mean TSH 16.64 uIU/mL]; 5% subclinical [mean TSH 6.62 uIU/mL]). The median time at risk was 8 and 16 months for overt and subclinical hypothyroidism, respectively. Fifty-six percent had persistent hypothyroidism (median TSH 16.75, p = 0.009). The average time to recovery of transient hypothyroidism was 39 months. Ten percent had hyperthyroidism with a median time at risk of 1.5 months. Non-small cell lung cancer and renal cell carcinoma were possible associated risk factors of thyroid dysfunction.
Conclusion. TKI-induced thyroid dysfunctions are common. Screening and monitoring for thyroid abnormalities during TKI therapy is important.
Zastosowanie analizy spektralnej do weryfikacji hipotezy o rozłączeniu się gospodarek rozwiniętych i wschodzących
Authors: Stańczyk Zbigniew , Wyrobek Joanna 
Published: September 2024

The paper discusses the viability of the decoupling hypothesis, which states that the performance of emerging economies becomes relatively independent from the changes in developed economies, and empirically verifies this hypothesis in the light of global economic developments over the past decade. Despite a very influential paper by Kose, Otrok, and Prasad (2008), we argue that there is no evidence that decoupling between developed and emerging economies took place before the last global financial crisis. In fact, the case was quite the contrary ‒ ties between the two groups of countries strengthened during the crisis years. It seems that either decoupling never took place or the recent crisis began a new trend of re-coupling, which is the instance of emerging economies returning to a state of strong dependence on their more developed counterparts. At the same time it raises doubts as to whether the high rates of growth in emerging economies can be sustained in the face of slowing growth in developed economies. In terms of methodology, linear and quadratic de-trending were used to obtain stationary data, then non-cyclical movements were removed with the Christiano-Fitzgerald band-pass filter. The cyclical parts of real GDP time series were then subjected to spectral and co-spectral analysis.
Wzorce kulturowe a ustawa hazardowa
Authors: Frańczuk Magdalena 
Published: September 2024

The study focuses on the recent amendments to the Act of 19 November 2009 on gambling (Journal of Laws of 2009, No. 201, item 1540, as amended). Issues were discussed from both socio-cultural and legal perspectives. The socio-legal approach to gambling looks at the history of and present day gambling. In addition to reflections of a sociological nature, the paper focuses on the legal definition of gambling, the latest regulations governing it, and, above all, the shortcomings in the regulation of protective provisions, which may lead to hazards, especially among inexperienced players involved in online gambling. The benefits of liberalising online gambling regulations in some EU countries are also analysed. The paper examines the risks and benefits of gambling in terms of social, religious and legal norms, and also compares appropriate normative orders in that field. The final section suggests changes that should be made to the gambling act in order to protect players from becoming addicted to gambling.
Wygląd i geograficzna symbolika herbów współczesnych państw Ameryki Południowej
Authors: Wrona Jerzy 
Published: September 2024

The coats of arms of the countries of South America contain elements harking back to both the history and geography of particular countries. The coats of arms of many countries of this region contain references to land forms (e.g. Chimborazo), vegetation and the animal world. The coats of arms of as many as four states (Bolivia, Ecuador, Chile and Columbia) are crowned with the silhouette of the condor, which, for states from the region of the Andes Mountains, has been the embodiment of freedom and national force since the times of Spanish colonisation. The coats of arms of Bolivia and Peru emphasise the role of llamas and related animals in the lives and economies of the Indigenous people. Horns of plenty symbolise mineral resources in the coats of arms of Columbia, Peru and Venezuela. While a sheaf of wheat underscores the importance of agriculture in the economies of Bolivia and Venezuela, coffee and tobacco branches in the coats of arms of Brazil symbolise the huge importance of these crops as exports.
Analiza zmian oksydacyjnych i zawartości kwasów tłuszczowych w oleju „Kujawski" pod wpływem ogrzewania mikrofalowego
Authors: Ostasz Lidia 
Published: September 2024

The goal of this study was to analyse the qualitative changes occurring in oil during microwave heating. The subject of the study was Kujawski oil, manufactured by ZT Kruszwica, and purchased retail. Oil samples were heated in an RM 800 microwave reactor. Microwaves at a power of 200, 400, 600 and 800 W were used. The heating duration for the oil samples ranged from 3 to 30 minutes. As a result of heating, the oils were observed to increase in temperature depending on the microwave power. This resulted in oxidative changes in the oil samples, as evidenced by the increase in the values on the peroxide, anisidine and Totox index. The values for these parameters increased over time in all the analysed oil samples. In oils heated by a microwave power of 400-800W, changes in the anisidine value and Totox index over time are illustrated by increasing convex curves. The higher the power of the microwave, the higher the value of this parameter observed in the samples. The highest anisidine value, equal to 143.8, was found in oil samples heated by 800 W microwaves for 30 minutes. The highest Totox value - 155.4 mEq O2/kg - occurred in oil samples heated by 800 W microwaves for 30 minutes.
Comparative in-Vitro dissolution study of some sitagliptin generic tablets under biowaiver conditions by UV-Spectroscopy
Authors: Adhao Vaibhav S. , Ambhore Jaya P. , Bhuskat Anant D. , Talokar Dishali V. 
Published: September 2024

The objective of this study is to evaluate the bioequivalence of generic sitagliptin tablets from different manufacturers using in-vitro dissolution study under biowaiver conditions through UV Spectroscopy, and compare them with the innovator brand. The dissolution media consisted of three different buffers with varying pH levels, including HCl Buffer pH 2.0, Phosphate Buffer pH 4.0, and Phosphate Buffer pH 7.2. The dissolution process was conducted using a USP type-2 dissolution apparatus with a 900 ml basket. The rotational speed of the paddle was set at 50 RPM, while maintaining a temperature of 37.5°C +/- 2°C. Samples were collected at four different intervals as recommended by the USFDA, which were 15, 30, 45, and 60 minutes. Validation parameters such as Accuracy, Precision, Linearity, LOD, and LOQ were assessed. The dissolution profiles exhibited no significant variability between different brands and within the same brand. Furthermore, the dissolution results of all tablet formulations, including the innovator brand, were analysed using the difference factor (f1) and similarity factor (f2). The findings from this study indicate that both generic brands of sitagliptin tablets meet the USFDA dissolution specifications and can be considered interchangeable.
Kintamani Bali Chinese Ethnic Religious Hybridity: A Dualism of Cultural Identity
Authors: Hendra Hendra Agus Prayoga , Khaidir Afriva 
Published: September 2024

This research aim was to explore the form of religious hybridity carried out by the Kintamani Bali Chinese ethnic group as part of the diversity of Chinese ethnicity in Indonesia. Regarding religious hybridity in the Kintamani Balinese Chinese ethnic group, the reason for choosing thisresearch was because the Balinese Chinese ethnicity is different from the Chinese Indonesian ethnicity in general; here they find unification and assimilation with Balinese culture, resulting in a dualism of cultural identity. This research used a qualitative approach with ethnographicmethods, data collection through participant observation and in-depth interviews, and is supported by other secondary references. This research was analyzed using Homi Bhabha’s hybridity theory and Parson’s functional theory. Research results show since the arrival of ethnic Chinese in northern Bali, they have established economic and political relations with the Bangli kingdom, where there is a good relationship between ethnic Chinese and the king of Bangli, so that it has an impact on the social and cultural life of the Balinese Chinese ethnic, namely the existence of religious hybridity that occurs. The first can be seen in terms of religious rituals such as daily prayer activities, Second, there is hybridization in terms of places of worship, The third is hybridization in terms of religious ornamentsand worship facilities. The causal factor is the first one amalgamation, a belief and philosophy of life for the Kintamani Chinese ethnic group, the existence of past history and open relationships, high tolerance, opennessto differences, and not questioning religious issues. A new identity, namely the dualism of cultural identity attached to the Kintamani Chinese ethnic group. Therefore, this plays a role in the socio-cultural life of the village and creates harmony with the Balinese Hindu community.
Contestation of Islamic Discourses: Responses of West Sumatra Scholars to Contemporary Religious Discourses
Authors: Saputra Riki , Arrasyid Arrasyid , Ritonga Mahyudin 
Published: September 2024

This study aimed to elucidate Islamic discourses and the responses of scholars, particularly in West Sumatra, to contemporary religious issues. A qualitative and a socio-anthropological method was adopted. The result showed that the tug-of-war in religious discourses in West Sumatra was both negotiating and confrontational with a dynamical and sharply dialectical religious discourse. In West Sumatra where religion was considered as life philosophy, scholars were placed in a highly central position in confronting the dynamics in the community. Consequently, the responses of scholars were significant and transformative with substantial strength.
Life imprisonment in Poland: Issues and Challenges
Authors: Polak-Kruszyk Aleksandra 
Published: September 2024

Purpose of the study: The purpose of this article is to analyze recent legislative changes to life imprisonment in Poland and to examine the consequences of introducing an absolute form of this penalty, called “an absolute life sentence”.
Methodology: This paper combines two methods: a comparison of legal documents and legal writers' thoughts and author observation of this phenomenon.
Main findings of the study: The main conclusion is that the changes introduced by the legislator concerning life imprisonment —specifically, the court discretion to optionally impose a parole ban under two circumstances— may not result in positive effects for crime deterrence. Consequently, this could worsen the already challenging task of educational rehabilitation efforts with the population of life prisoners. The Polish penitentiary system will face challenges related to ageing prisoners serving life sentences without parole and the natural consequences of this issue. Furthermore, the recent changes could make it difficult for Poland to cooperate on criminal law matters with countries that consider 'absolute life imprisonment' to be inhumane.
Application of the study: The presented research relates to various scientific fields, e.g. criminal law, executive penal law and sociology.
Originality/Novelty of the study: This problem is still a current matter. Life imprisonment is a relatively new punishment in Poland, and the Polish penitentiary system continues to look for new ways and methods for dealing with group of life-sentenced prisoners. As a result of the latest amendment, the Polish prison administration will once again face the challenge of implementing completely new severe penalty which is a life imprisonment.
Representasi Father Involvement Dalam Film Stranger Things Season 2
Authors: Nastiyar Firdaus Algim , Tanjung Sumekar 
Published: September 2024

The image of masculinity positioning fathers as central figures in earning a living has implications for the lack of paternal involvement in child-rearing, known as fatherlessness or daddy issues. This research uses the film “Stranger Things” (2017) to provide insights into how father involvement is represented. The study aims to understand how elements of father involvement are depicted in the film “Stranger Things” (2017). The research employs Roland Barthes’ semiotic analysis method, which examines the significance of denotation and connotation. The results show that aspects of father involvement represented in the film are divided into four indicators: (1) authoritarian attitude, (2) portrayal of feminist men, (3) role model for children, and (4) temperamental nature. Thus, it can be concluded that father’s involvement in child-rearing can open new windows into breaking the boundaries of the image of masculinity in societal reality.