bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Thrombotic Risk in Atrial Fibrillation with Ultrasound Molecular Imaging of P-Selectin
Authors: Jing Yuanwen , Hu Yinlan , Li Hairui , Wang Junfen , Si Xiaoyun , Zheng Hao , Liu Jian , Liao Wangjun , Liao Yulin , Bin Jianping 
Published: January 2018

AbstractMolecular imaging of inflammatory mediators in atria may contribute to thrombotic risk assessment of atrial fibrillation (AF). We investigated the feasibility of ultrasound molecular imaging (UMI) targeted to P-selectin to assess thrombotic risk in AF. Rat AF models were established with rapid atrial pacing. Microbubbles targeted to P-selectin were injected into the rats, followed by left atrial (LA) UMI examination. Furthermore, P-selectin, platelets (PLTs), fibrin and tissue factor (TF) of LA were detected by histopathology and scanning electron microscopy. Plasma levels of P-selectin, thrombin-antithrombin complex (TAT) and prothrombin fragment 1 + 2 (F1 + 2) were measured by enzyme-linked immunosorbent assay. The data showed that P-selectin in LA was correlated with PLT, fibrin and TF (r = 0.735, p < 0.05; r = 0.827, p < 0.05; r = 0.785, p < 0.05, respectively). The plasma level of P-selectin was correlated with the expression of TAT and F1 + 2 (r = 0.866, p < 0.05; r = 0.916, p < 0.05, respectively). The contrast video intensity of adhered microbubbles targeted to P-selectin was correlated with the levels of P-selectin, PLT and fibrin in LA (r = 0.768, p < 0.05; r = 0.798, p < 0.05; r = 0.745, p < 0.05, respectively). In conclusion, P-selectin may serve as a biomarker for thrombotic risk in AF and can be quantified by UMI to assess thrombotic risk.
Dimeric Glycoprotein VI Binds to Collagen but Not to Fibrin
Authors: Ebrahim Mariam , Jamasbi Janina , Adler Kristin , Megens Remco , M'Bengue Yacine , Blanchet Xavier , Uhland Kerstin , Ungerer Martin , Brandl Richard , Weber Christian , Elia Natalie , Lorenz Reinhard , Münch Götz , Siess Wolfgang 
Published: January 2018

AbstractPlatelet glycoprotein VI (GPVI) acts as a decisive collagen receptor in atherothrombosis. Besides collagen, injured atherosclerotic plaques expose tissue factor (TF) that triggers fibrin formation. Two recent studies reported that platelet GPVI also functions as fibrin receptor, which would importantly widen the mode of action of GPVI-targeted antithrombotic drugs. We studied the binding of two GPVI fusion proteins to fibrin under static and arterial flow conditions. Fibrin was prepared from purified fibrinogen or generated more physiologically from endogenous fibrinogen by coagulating plasma with thrombin. Fibrin formation was also triggered by exposing TF-coated surfaces or human atherosclerotic plaque slices to arterially flowing blood. By binding studies and advanced optical imaging, we found that recombinant dimeric GPVI-Fc fusion proteins with Fc from either IgG1 (GPVI-Fc1) or IgG2 (GPVI-Fc2) bound to collagen fibres, but neither to fibrin prepared from purified fibrinogen obtained from three suppliers, nor to physiological fibrin formed by thrombin in plasma or triggered by exposing TF or atherosclerotic plaque slices to arterially flowing blood. Our findings do not support a role of dimeric platelet GPVI as receptor for fibrin. This is important for the understanding of plaque-triggered platelet thrombus formation and is clinically relevant for future GPVI-targeting therapies with recombinant GPVI-Fc and anti-GPVI antibodies.
Urban Particulate Matter Induces Changes in Gene Expression in Vascular Endothelial Cells that Are Associated with Altered Clot Structure In Vitro
Authors: Pan Xiaoxi , Gong Yun , Xu Ya , Ariens Robert , Routledge Michael 
Published: January 2018

Background Particulate matter contained in ambient air pollution has been associated with cardiovascular diseases in several epidemiological studies.
Objective The aim of this study was to investigate the potential for urban particulate matter to induce changes in clot structure through interaction with vascular endothelial cells.
Methods We examined the structure of clots formed on human umbilical vascular endothelial cells that had been treated with various types of particles versus those formed on untreated cells. Particles used were standard reference particulate matter from diesel engine emissions (SRM2975) and urban ambient collection (SRM2787).
Results There was a dose-dependent increase in fibre density in clots formed on particle-treated endothelial cells. It was also found that exposure to the particles induced increased expression of tissue factor and reduced expression of thrombomodulin genes as measured by real-time polymerase chain reaction and increased expression of von Willebrand factor and plasminogen activation inhibitor-1 as measured by ELISA.
Conclusion These changes are consistent with increased procoagulant activity of air pollution particulate matter–treated endothelial cells and suggest that particulate matter has the potential to promote clot formation through changes induced in endothelial genes controlling clot formation.
Impact of Reticulated Platelets on the Antiplatelet Effect of the Intravenous P2Y12-Receptor Inhibitor Cangrelor
Authors: Stratz Christian , Nührenberg Thomas , Valina Christian , Löffelhardt Nikolaus , Mashayekhi Kambis , Ferenc Miroslaw , Trenk Dietmar , Neumann Franz-Josef , Hochholzer Willibald 
Published: January 2018

Background Reticulated platelets are associated with impaired antiplatelet response to irreversibly acting P2Y12-receptor inhibitors. However, the impact of reticluated platelets (RP) on the reversibly acting injectable P2Y12-receptor inhibitor cangrelor is unknown. Thus, this study sought to investigate the influence of RP on cangrelor and transitioning strategies to oral P2Y12-receptor inhibitors.
Methods This study randomized 110 patients undergoing elective percutaneous coronary intervention with use of cangrelor to different oral transitioning strategies loading with prasugrel 60 mg or ticagrelor 180 mg at the start of cangrelor (n = 45 each) or loading with clopidogrel 600 mg after discontinuation of cangrelor (n = 20). ADP-induced platelet reactivity was assessed by impedance aggregometry. Reticulated platelets were analysed by an automated whole blood flow cytometry and described as immature platelet count.
Results There was no correlation of reticulated platelets and ADP-induced platelet reactivity in patients under treatment with cangrelor (r = 0.06, p = 0.47). This finding was consistent in all three transitioning strategies. On day 1 following treatment with cangrelor, the correlation of reticulated platelets and platelet reactivity was detectable again in patients receiving thienopyridines but not ticagrelor (all patients r = 0.37, p < 0.001; clopidogrel: r = 0.59, p = 0.01; prasugrel: r = 0.47, p < 0.001; ticagrelor r = 0.22, p = 0.13).
Conclusion Platelet inhibition is not influenced by levels of reticulated platelets during infusion of cangrelor independent of oral P2Y12-receptor inhibitor transitioning strategy. These findings underline the potency of cangrelor as immediate and reversibly acting P2Y12-receptor inhibitor.
Casa Revista: arquitetura de fonte aberta
Authors: Passaro Andrés , Rohde Clarice 
Published: January 2018

A popularização das novas tecnologias de fabricação digital vêm alterando os modos de produção da sociedade contemporânea. O compartilhamento aberto de informações, dentro de uma nova lógica produtiva, tem o potencial de mudar o sistema econômico vigente, e de até transformar os rumos da globalização em curso. O presente trabalho aborda um novo sistema construtivo de fonte aberta que utiliza a fabricação digital na produção de habitações de baixo custo. O projeto Casa Revista, desenvolvido no laboratório LAMO3D da FAU-UFRJ, tem como objetivo alimentar a renovação da produção independente de habitações, inserindo uma nova tecnologia construtiva no vocabulário popular e explorando seus potenciais. Baseado no sistema WikiHouse de construção, o projeto alia conhecimento global à produção local, tropicalizando o seu conteúdo. A experiência contou com a prototipagem em escala real de um primeiro modelo, usinado e montado por estudantes da graduação, a fim de testar a qualidade do sistema e sua viabilidade técnica de implementação como tecnologia social. O projeto mostrou-se intuitivo, de complexidade simples e rico em possibilidades de manipulação e aperfeiçoamento. São os projetos e tecnologias de fonte aberta que vêm promovendo o alargamento de usos do conhecimento por novos atores, gerando uma dispersão da produção. Cabe a nós arquitetos reconhecermos esse potencial e moldar suas infinitas possibilidades de aplicação.
Association Between Hospital Volume, Processes of Care, and Outcomes in Patients Admitted With Heart Failure
Authors: Kumbhani Dharam J. , Fonarow Gregg C. , Heidenreich Paul A. , Schulte Phillip J. , Lu Di , Hernandez Adrian , Yancy Clyde , Bhatt Deepak L. 
Published: January 2018

Background:
Hospital volume is frequently used as a structural metric for assessing quality of care, but its utility in patients admitted with acute heart failure (HF) is not well characterized. Accordingly, we sought to determine the relationship between admission volume, process-of-care metrics, and short- and long-term outcomes in patients admitted with acute HF.

Methods:
Patients enrolled in the Get With The Guidelines-HF registry with linked Medicare inpatient data at 342 hospitals were assessed. Volume was assessed both as a continuous variable, and quartiles based on the admitting hospital annual HF case volume, as well: 5 to 38 (quartile 1), 39 to 77 (quartile 2), 78 to 122 (quartile 3), 123 to 457 (quartile 4). The main outcome measures were (1) process measures at discharge (achievement of HF achievement, quality, reporting, and composite metrics); (2) 30-day mortality and hospital readmission; and (3) 6-month mortality and hospital readmission. Adjusted logistic and Cox proportional hazards models were used to study these associations with hospital volume.

Results:

A total of 125 595 patients with HF were included. Patients admitted to high-volume hospitals had a higher burden of comorbidities. On multivariable modeling, lower-volume hospitals were significantly less likely to be adherent to HF process measures than higher-volume hospitals. Higher hospital volume was not associated with a difference in in-hospital (odds ratio, 0.99; 95% confidence interval [CI], 0.94–1.05;
P
=0.78) or 30-day mortality (hazard ratio, 0.99; 95% CI, 0.97–1.01;
P
=0.26), or 30-day readmissions (hazard ratio, 0.99; 95% CI, 0.97–1.00;
P
=0.10). There was a weak association of higher volumes with lower 6-month mortality (hazard ratio, 0.98; 95% CI, 0.97–0.99;
P
=0.001) and lower 6-month all-cause readmissions (hazard ratio, 0.98; 95%, CI 0.97–1.00;
P
=0.025).

Conclusions:
Our analysis of a large contemporary prospective national quality improvement registry of older patients with HF indicates that hospital volume as a structural metric correlates with process measures, but not with 30-day outcomes, and only marginally with outcomes up to 6 months of follow-up. Hospital profiling should focus on participation in systems of care, adherence to process metrics, and risk-standardized outcomes rather than on hospital volume itself.
Point Downscaling of Surface Wind Speed for Forecast Applications
Authors: Tang Brian H. , Bassill Nick P. 
Published: January 2018

AbstractA statistical downscaling algorithm is introduced to forecast surface wind speed at a location. The downscaling algorithm consists of resolved and unresolved components to yield a time series of synthetic wind speeds at high time resolution. The resolved component is a bias-corrected numerical weather prediction model forecast of the 10-m wind speed at the location. The unresolved component is a simulated time series of the high-frequency component of the wind speed that is trained to match the variance and power spectral density of wind observations at the location. Because of the stochastic nature of the unresolved wind speed, the downscaling algorithm may be repeated to yield an ensemble of synthetic wind speeds. The ensemble may be used to generate probabilistic predictions of the sustained wind speed or wind gusts. Verification of the synthetic winds produced by the downscaling algorithm indicates that it can accurately predict various features of the observed wind, such as the probability distribution function of wind speeds, the power spectral density, daily maximum wind gust, and daily maximum sustained wind speed. Thus, the downscaling algorithm may be broadly applicable to any application that requires a computationally efficient, accurate way of generating probabilistic forecasts of wind speed at various time averages or forecast horizons.
Representation of Extratropical Cyclones, Blocking Anticyclones, and Alpine Circulation Types in Multiple Reanalyses and Model Simulations
Authors: Rohrer Marco , Brönnimann Stefan , Martius Olivia , Raible Christoph C. , Wild Martin , Compo Gilbert P. 
Published: January 2018

Abstract
Atmospheric circulation types, blockings, and cyclones are central features of the extratropical flow and key to understanding the climate system. This study intercompares the representation of these features in 10 reanalyses and in an ensemble of 30 climate model simulations between 1980 and 2005. Both modern, full-input reanalyses and century-long, surface-input reanalyses are examined. Modern full-input reanalyses agree well on key statistics of blockings, cyclones, and circulation types. However, the intensity and depth of cyclones vary among them. Reanalyses with higher horizontal resolution show higher cyclone center densities and more intense cyclones. For blockings, no strict relationship is found between frequency or intensity and horizontal resolution. Full-input reanalyses contain more intense blocking, compared to surface-input reanalyses. Circulation-type classifications over central Europe show that both versions of the Twentieth Century Reanalysis dataset contain more easterlies and fewer westerlies than any other reanalysis, owing to their high pressure bias over northeast Europe. The temporal correlation of annual circulation types over central Europe and blocking frequencies over the North Atlantic–European domain between reanalyses is high (around 0.8). The ensemble simulations capture the main characteristics of midlatitudinal atmospheric circulation. Circulation types of westerlies to northerlies over central Europe are overrepresented. There are too few blockings in the higher latitudes and an excess of cyclones in the midlatitudes. Other characteristics, such as blocking amplitude and cyclone intensity, are realistically represented, making the ensemble simulations a rich dataset to assess changes in climate variability.
Fast Physics and Slow Physics in the Nonlinear Dansgaard–Oeschger Relaxation Oscillation
Authors: Vettoretti Guido , Peltier W. Richard 
Published: January 2018

AbstractThe Dansgaard–Oeschger (D-O) relaxation oscillation that governed glacial climate variability during marine isotope stage 3 has been accurately simulated using a high-resolution coupled climate model. Here the authors present additional detailed analyses of both the slow physics transition between warm and cold states and the fast physics transition between cold and warm states of the D-O cycle. First, the authors demonstrate that the mechanisms active during the slow transition from interstadial to stadial conditions involves the continuous flux of thick and old sea ice from the Arctic basin into the North Atlantic subpolar gyre region along the East Greenland Current. During this slow physical process, the freshwater input from sea ice melting as it moves over the surface of the warm ocean restratifies the high-latitude North Atlantic and leads to a significant reduction in the rate of North Atlantic Deep Water formation. A detailed freshwater budget and hydrography analysis is also presented to demonstrate that the D-O cycle is a low-latitude–high-latitude salt oscillator as the authors have previously argued. Second, the authors provide a more detailed analysis than previously of the fast-time-scale processes that govern the extremely rapid transition from cold stadial conditions back to the warm interstadial state. These are associated with the onset of a sub-sea ice thermohaline convective instability, which opens a massive polynya to the north of the southern boundary of the extensive North Atlantic sea ice lid that is characteristic of stadial conditions. This instability is enabled by the continuous increase of salinity above the sub-sea ice pycnocline, which eliminates the vertical salinity gradient that prevents convective destabilization of the water column under full stadial conditions. This reduction in the vertical salinity gradient beneath the sea ice lid results from the continuing northward salt transport by the North Atlantic gyre circulation once the expansion of the stadial sea ice lid has ceased. The onset of instability occurs in the Irminger basin to the south of Denmark Strait, and the authors discuss the reason for this localization of instability onset.
Can evolutionary mismatch help generate interest in health promotion messages?
Authors: Grey Elisabeth B , Gillison Fiona B , Thompson Dylan 
Published: January 2018

Background: Generating interest in health interventions is an important first step towards engagement with health promotion and effecting behaviour change. This study explored whether framing health information about physical activity and diet from an evolutionary mismatch perspective could help to generate interest in health promotion among overweight and inactive adults. Evolutionary mismatch theory proposes that human cultural evolution has occurred too rapidly for biological evolution to keep up, creating a mismatch between genes and lifestyles that gives rise to chronic diseases such as type 2 diabetes. Method: A total of 18 adults completed interviews in which they viewed and discussed a variety of mismatch-framed health information resources. Follow-up questions assessed if and what participants had thought about the information in the week after the interview. Transcripts were thematically analysed. Results: Participants found the evolutionary perspective to be novel and interesting. It also provided a meaningful rationale for behaviour change. However, there was some evidence of negative elaboration, which would need to be managed if implementing this approach. Conclusion: Adopting a mismatch perspective can help to engage audiences with important health information.
Incidence, Severity, and Time Loss Associated With Collegiate Football Fractures, 2004-2005 to 2013-2014
Authors: Cairns Mark A. , Hasty Eddie K. , Herzog Mackenzie M. , Ostrum Robert F. , Kerr Zachary Y. 
Published: January 2018

Background: The inherent risk of any time loss from physical injury in football has been extensively discussed, with many such injuries having a profound effect on the lives of National Collegiate Athletic Association (NCAA) football players. However, the incidence of fractures in collegiate football has not been well established. Purpose: To examine the epidemiology of fractures in NCAA football. Study Design: Descriptive epidemiology study. Methods: Fracture data reported in college football during the 2004-2005 to 2013-2014 academic years were analyzed from the NCAA Injury Surveillance Program (NCAA-ISP). Fracture rates per 1000 athlete-exposures, surgery and time loss distributions, injury rate ratios, injury proportion ratios (IPRs), and 95% CIs were reported. Results: Overall, 986 fractures were reported. The rate of competition fractures was larger than the rate of practice fractures (1.80 vs 0.17 per 1000 athlete-exposures; injury rate ratio = 10.56; 95% CI, 9.32-11.96). Fractures of the hand/fingers represented 34.6% of all injuries, while fibula fractures (17.2%) were also common. A majority (62.5%) of all fractures resulted in time loss >21 days. Altogether, 34.4% of all fractures required surgery, and 6.3% were recurrent. The proportion of fractures resulting in time loss >21 days was higher for fractures requiring surgery than fractures not requiring surgery (85.0% vs 50.7%; IPR = 1.68; 95% CI, 1.53-1.83). The proportion of recurrent and nonrecurrent fractures requiring surgery did not differ (35.5% vs 34.3%; IPR = 1.03; 95% CI, 0.73-1.46); however, recurrent fractures were more likely to require surgery than nonrecurrent fractures when restricted to the hand/fingers (66.7% vs 27.2%; IPR = 2.45; 95% CI, 1.36-4.44). Conclusion: Fractures in collegiate football were sustained at a higher rate in competition than practice and frequently required extended time lost from participation, particularly among those requiring surgery. Prevention strategies are warranted to reduce incidence and severity of fractures.
Perceived Environments as Physical Activity Correlates and Moderators of Intervention in Five Studies
Authors: King Abby C. , Toobert Deborah , Ahn David , Resnicow Ken , Coday Mace , Riebe Deborah , Garber Carol E. , Hurtz Shannon , Morton Jessica , Sallis James F. 
Published: January 2018

Purpose Few studies have explored how relationships of perceived environment and physical activity vary across different activity domains and populations. This question was explored in five physical activity intervention trials funded by the National Institutes of Health Behavior Change Consortium. Design Observational. Settings San Francisco peninsula, California (N = 94); Eugene, Oregon (N = 122); Atlanta, Georgia (N = 256); Kingston, Rhode Island (N = 109); Memphis, Tennessee (N = 64). Subjects Ethnically diverse community adults ages 18 to 85 years. Measures The Neighborhood Environment Walkability Scale and CHAMPS physical activity questionnaire. Response rate among those invited to complete these measures was 90%. Results Cross-sectional pooled signal detection analysis indicated that people who reported living in neighborhoods with more attractive scenery and ease of walking were more likely to meet national physical activity recommendations (67%) compared with those without these neighborhood attributes (36%, χ2 = 13.04, p = .0003). Within-site multiple regression identified two additional variables–-seeing others when walking and encountering loose dogs that make it difficult to walk–-as correlates across multiple sites and activity domains (i.e., minutes of weekly moderate or more vigorous activity, walking for errands, walking leisurely) (incremental R2 = 2.0–7.5; p < .05). Analyses of covariance suggested that traffic safety might be particularly important in facilitating or impeding physical activity in response to a formal intervention (for traffic-arm assignment interactions, F = 3.8–7.0, p ≤ .05). Conclusions Relationships between perceived environments and physical activity may differ depending upon population groups and activity domains and merit investigation by using stronger prospective designs.