bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conducting marine genetic research for whom? Mapping knowledge flows from science to patents
Authors: Dunshirn Paul , Zhivkoplias Erik 
Published: October 2024

AbstractMarine genetic resources hold great value for biotechnological innovation and sustainability-oriented research. However, studies indicate that intellectual property rights pertaining to these resources are concentrated in a handful of companies and countries, triggering contentious international debates. This paper highlights an overlooked dimension: the flow of scientific knowledge in the provision and use of marine genetic research. We identified 23,417 scientific studies that use marine genetic sequences, traced patent references to these studies, and revealed provider and user countries. We found that molecular biological research, oftentimes on bacterial species, attracted the most patenting interest. Some countries owned relatively more patents than they provided in science, with the U.S. benefiting the most from available research. Science by developing countries’ researchers saw limited uptake in patents. These findings aim to inform international biodiversity regimes, such as the UN Treaty on Biodiversity Beyond National Jurisdiction (BBNJ), on how to more equitably distribute marine genetic resources’ economic, socio-cultural, and ecological benefits.
Biomechanical comparison of the tensile strength of fixation implants used for pull-out repair of medial meniscus posterior root tear
Authors: Handa Mikiko , Takahashi Tsuneari , Takeshita Katsushi 
Published: October 2024

Purpose: Medial meniscus posterior root tears (MMPRT) pull-out repair aims to restore the meniscus’ anatomical structure. Different implants are utilized for thread fixation in the pull-out repair technique for MMPRT. However, biomechanical evidence comparing the fixation strengths of these implants remains unavailable. This study investigated the tensile strength of three fixation implants in porcine knee models of MMPRT pull-out repair. Methods: This study categorized 30 porcine MMPRT models undergoing pull-out repair into three groups (10 specimens each) based on the implant utilized for fixation, including double spike plate, metallic interference screw (IFS), and resorbable IFS fixed group. A tensile tester was used to track the suture wire threaded to the medial meniscus anterior root. The displacement length was recorded after 10 and 20 loading cycles (10–30 N, 100 mm/min cross-head speed). Each specimen was then stretched to failure (50 mm/min cross-head speed), failure modes were recorded, and structural properties (maximum load, linear stiffness, elongation at failure, and elongation at yield) were compared. Fisher’s exact test and one-way analysis of variance were utilized to assess the differences. Results: No significant differences in displacement length, upper yield load, maximum load, linear stiffness, elongation at yield, elongation at failure, and frequency of failure mode were observed between the three groups. Conclusion: All implants were comparable in terms of fixation strength. Thus, resorbable interference screws may be particularly useful in this technique and does not require implant removal surgery. Level of evidence: IV.
Renale Sarkoidose
Authors: Bergner Raoul , Löffler Christian 
Published: October 2024

ZUSAMMENFASSUNGDie Sarkoidose ist in Nordeuropa die häufigste granulomatöse Erkrankung. Man unterscheidet zwischen akuten Formen der Sarkoidose (Löfgren-Syndrom, Heerfordt-Syndrom) und der chronischen Sarkoidose. Die chronische Sarkoidose kann nahezu alle Organe betreffen. Die Lunge ist das am häufigsten betroffene Organ. Die Niere ist mit ca. 30 % der Fälle bei gründlicher Diagnostik nach der Lunge eines der am häufigsten mitbeteiligten Organe. Die in der Diagnostik gefundenen Befunde sind jedoch meistens wenig spektakulär und reichen von einer geringen Proteinurie über eine sterile Leukozyturie bis zu einer eingeschränkten Nierenfunktion. Meistens kann erst eine Nierenbiopsie den Befund einer renalen Sarkoidose oder sekundären Glomerulonephritis klären. Bedingt durch Störungen im Kalziumstoffwechsel können zudem eine Nephrokalzinose oder Nephrolithiasis auftreten. Auch Kombinationen der verschiedenen renalen Befunde sind möglich. Die Therapie der renalen Sarkoidose besteht in erster Linie aus Kortikosteroiden. Die Evidenz dafür beruht jedoch nur auf Fallserien. Andere Immunsuppressiva werden in der Literatur kasuistisch beschrieben.
Leitlinien im und für den Öffentlichen Gesundheitsdienst: Ergebnisse
einer Onlinebefragung zu aktuellen Bedarfen aus der Praxis
Authors: Arnold Laura , Steinisch Maria , Kuehne Anna , Schwabe Anna , Jakubowski Elke , Scholten Anjali , Stratil Jan M 
Published: October 2024

ZusammenfassungEvidenzbasierte Leitlinien sind im medizinischen Praxisalltag anerkannt und
etabliert. Im Öffentlichen Gesundheitsdienst (ÖGD) sind evidenzbasierte
Leitlinien jedoch bislang nicht umfassend verfügbar. Um die Entwicklung von
Leitlinien im und für den ÖGD zu fördern, hat der Gemeinsame Bundesausschuss
(GBA) im Juni 2024 eine Förderrichtlinie herausgegeben. Diese Studie präsentiert
die Ergebnisse einer Onlinebefragung zur Priorisierung von Leitlinienthemen im
ÖGD, durchgeführt von der Deutschen Gesellschaft für Öffentliches
Gesundheitswesen e.V. (DGÖG). Die Befragung fokussierte auf fokussierte auf die
17 vom GBA vorgeschlagene Leitlinienthemen, die in sechs ÖGD-Aufgabenbereiche
gegliedert sind. Von insgesamt über 900 Teilnehmenden wurden umfassende
Antworten von knapp 500 Teilnehmenden ausgewertet, von denen 85 Prozent in
kommunalen Gesundheitsämtern tätig sind. Die Ergebnisse zeigten, dass allen 17
Leitlinienthemen eine hohe oder sehr hohe Priorität zugeschrieben wurde.
Besonders häufig hoch priorisiert wurden die Themenbereiche
infektionshygienische Überwachung, amtsärztliches Gutachtenwesen und
psychosoziale Notfallversorgung. Fachexperten hoben zudem die zahnmedizinische
Früherkennung, die Gesundheitskompetenz für Zahngesundheit und die Überwachung
von Trink- und Badewasser hervor. Die qualitative Analyse identifizierte darüber
hinaus weitere relevante Themen, darunter Gesundheitsberichterstattung und
-planung, Gesundheitsförderung und Prävention, Kindeswohl sowie Krisenmanagement
und Kommunikation. Die Umfrage ermöglicht Rückschlüsse über die aus ÖGD-Praxis
und -Wissenschaft wahrgenommenen prioritären Themen für Leitlinien. Die
Ergebnisse verdeutlichen den großen Bedarf an evidenzbasierten Leitlinien im und
für den ÖGD und liefern wichtige Erkenntnisse für die weitere Entwicklung und
Priorisierung.
Accuracy and Completeness of Bard and Chat-GPT 4 Responses for Questions Derived from the International Consensus Statement on Endoscopic Skull-Base Surgery 2019
Authors: Abgin Yavar , Umemoto Kayla , Goulian Andrew , Vasquez Missael , Polster Sean , Wu Arthur , Roxbury Christopher , Soni Pranay , Ahmed Omar G. , Tang Dennis M. 
Published: October 2024

AbstractArtificial intelligence large language models (LLMs), such as Chat Generative Pre-Trained Transformer 4 (Chat-GPT) by OpenAI and Bard by Google, emerged in 2022 as tools for answering questions, providing information, and offering suggestions to the layperson. These LLMs impact how information is disseminated and it is essential to compare their answers to experts in the corresponding field. The International Consensus Statement on Endoscopic Skull-Base Surgery 2019 (ICAR:SB) is a multidisciplinary international collaboration that critically evaluated and graded the current literature.
Objectives Evaluate the accuracy and completeness of Chat-GPT and Bard responses to questions derived from the ICAR:SB policy statements.
Design Thirty-four questions were created based on ICAR:SB policy statements and input into Chat-GPT and Bard. Two rhinologists and two neurosurgeons graded the accuracy and completeness of LLM responses, using a 5-point Likert scale. The Wilcoxon rank-sum and Kruskal–Wallis tests were used for analysis.
Setting Online.
Participants None.
Outcomes Compare the mean accuracy and completeness scores between (1) responses generated by Chat-GPT versus Bard and (2) rhinologists versus neurosurgeons.
Results Using the Wilcoxon rank-sum test, there were statistically significant differences in (1) accuracy (p < 0.001) and completeness (p < 0.001) of Chat-GPT compared with Bard; and (2) accuracy (p < 0.001) and completeness (p < 0.001) ratings between rhinologists and neurosurgeons.
Conclusion Chat-GPT responses are overall more accurate and complete compared with Bard, but both are very accurate and complete. Overall, rhinologists graded lower than neurosurgeons. Further research is needed to better understand the full potential of LLMs.
Novel Treatment Options in Patients with Maturity-Onset Diabetes of
the Young
Authors: Müssig Karsten 
Published: October 2024

AbstractMaturity-onset diabetes of the young (MODY) is the most common monogenetic form
of diabetes with an autosomal dominant inheritance pattern. MODY is caused by
mutations in genes important for the development and function of pancreatic beta
cells, resulting in impaired insulin secretion capacity. To date, 14 different
types have been described. While glucokinase (GCK)-MODY (formerly MODY-2)
generally requires no drug therapy, other forms of MODY, such as hepatocyte
nuclear factor-1-alpha (HNF1A)-MODY (formerly MODY-3) and HNF4A (formerly
MODY-1), usually respond very well to sulfonylurea therapy. However, these MODY
forms are characterised by a progressive course, meaning that insulin therapy is
often required as the disease progresses. Both sulfonylurea therapy and insulin
therapy are associated with an increased risk of hypoglycaemia and frequent
weight gain. Newer blood glucose-lowering therapies, such as SGLT2 inhibitors
(SGLT2i), DPP-4 inhibitors (DPP4i) and GLP-1 receptor agonists (GLP-1RA), have a
much lower risk of hypoglycaemia and usually have a favourable effect on body
weight. This review aims to provide an overview of the treatment of MODY
patients with SGLT2i, DPP4i and GLP-1RA on the basis of previously published
clinical studies, case series and case reports.
Poly(A)-Specific Ribonuclease Deficiency Leads to Deregulated Expression of Genes Involved in Sex Determination and Gonadal Maturation in Zebrafish
Authors: Felicitus Sujitha , Nanjappa Dechamma Pandyanda , Kalladka Krithika , Mohan Masmarika , Chakraborty Gunimala , Chakraborty Anirban 
Published: October 2024

Abstract
Background Deadenylation, the process of removal of poly (A) tail of messenger ribonucleic acids (mRNAs), is a rate-limiting step in mRNA stability, and poly(A)-specific ribonuclease (PARN) is the most important exonuclease involved in this process. Besides mRNA stability, PARN is also involved in several other processes including telomere maintenance, noncoding RNA maturation, ribosome biogenesis, and TP53 function. Previously, we have shown that zebrafish PARN null mutants are viable and fertile but turn out to only develop into males, indicating a role in oogenesis. The present study was focused on analyzing the expression of genes involved in sex determination and gonadal development in PARN mutant zebrafish.
Materials and Methods Total RNA was extracted and quantitative real-time polymerase chain reaction was performed to determine the expression level of genes involved in gonad development in PARN mutant embryos (4 days postfertilization [dpf]) and adults (120 dpf) in comparison to their wild-type siblings. The expression levels were estimated by the ΔΔCT relative quantification method.
Results At 4 dpf, the expression of germ cell-specific genes did not show any significant difference in the null mutants compared to the heterozygous and their wild-type siblings, suggesting no effect on germ cell differentiation due to the loss of PARN. However, the majority of the ovary-associated genes analyzed showed an increased expression in PARN null and heterozygous mutants compared to the wild-type siblings. Intriguingly, the expression of testis-associated genes showed decreased expression in the mutants compared to their wild-type siblings at 4 dpf. In adult stages, as expected, the expression of genes that jointly regulate the proper formation and function of ovaries and testes showed decreased expression in PARN null mutants. Interestingly, the expression of genes involved in the differentiation of testes, despite showing a decreased expression in the mutants, was comparable between the null and heterozygous mutants.
Conclusion Taken together, these results suggest that the loss of PARN does not affect germ cell differentiation but affects the sexual differentiation that happens at later stages of development, particularly the process of oogenesis, in zebrafish.
Craniotomy versus Decompressive Craniectomy in Acute Subdural Hematoma Management: A Systematic Review and Meta-Analysis
Authors: Al-Salihi Mohammed Maan , Al-Jebur Maryam Sabah , Al-Salihi Yezan , Dumour Elias , Saleh Ahmed , Daie Mhran , Hammadi Firas , Ayyad Ali 
Published: October 2024

Abstract
Background This study aimed to compare the clinical outcomes of decompressive craniectomy (DC) and craniotomy in treating acute subdural hematoma (ASDH) to provide a more precise assessment of the procedures' outcomes.
Methods We searched for relevant articles in PubMed, Web of Science, Embase, Scopus, and Cochrane till August 2023, including cohort studies and randomized controlled trials comparing craniotomy and DC for ASDH. The analysis was conducted using “Review Manager” software, using the risk ratio along with a 95% confidence interval (CI) for categorical data, whereas continuous data were analyzed using the mean difference (MD) and 95% CI.
Results Our analysis included 13 studies with a total of 4,689 patients, of whom 1,910 (40.7%) underwent DC and 2,779 (59.3%) underwent craniotomy. The results revealed a statistically significant difference in favor of craniotomy concerning good recovery in delayed GOS (risk ratio [RR] = 1.42; 95% CI [1.12, 1.81]), postoperative mortality (RR = 0.81; 95% CI [0.71, 0.94]), mortality at last follow-up (RR = 0.75; 95% CI [0.62, 0.91]), and hospital stay (MD = –3.71; 95%CI [–5.82, –1.60]). A nonsignificant difference (RR = 1.06; 95% CI [0.52, 2.17]; p = 0.87) was found between the two interventions concerning seizures.
Conclusion Despite craniotomy's favorable clinical outcomes and mortality rates, the significant baseline differences between DC and craniotomy make these data inconclusive. To establish solid evidence regarding the use of DC versus craniotomy in ASDH, it is necessary to conduct well-controlled randomized studies with large sample sizes.
The origin of broadband blue emission in zero-dimensional organic lead iodine perovskites: A first-principles study
Authors: Tan Jieyao , Jiang Xingxing , Liu Dongyu , Moghaddam Ahmad Ostovari , Stolyarov Vasily S. , Xiao Shifang , Vasenko Andrey S. 
Published: October 2024

Broadband blue emission in zero-dimensional perovskites has received considerable attention, which is very important for the realization of stable blue-light emitters; however, the underlying formation mechanism remains unclear. Based on first-principles calculations, we have systematically studied the self-trapped excitons (STEs) behavior and luminescence properties in 0D-(DMA)4PbI6 perovskite. Our calculations show that there is a significant difference between the intrinsic STE luminescence mechanism (∼2.51 eV) and experimental observations (∼2.70 eV). In contrast, we found that the iodine vacancy (VI) is energetically accessible and exhibits a shallow charge transition level at ∼2.69 eV (0/+1) above the valence band maximum, which provides the initial local well for the STEs formation. Moreover, the low electronic dimension synergistic Jahn–Teller distortion facilitates the formation of extrinsic excitons self-trapping. Further excited state electronic structure analysis and configuration coordinate diagram calculations confirmed that the broadband blue emission in 0D-(DMA)4PbI6 is the origin of VI-induced extrinsic STEs instead of intrinsic STEs. Therefore, our simulation results rationalize the experimental phenomena and provide important insights into the formation mechanism of STEs in low-dimensional perovskite systems.
Knowledge distillation-based abnormal power consumption pattern detection for edge environment
Authors: Fan Yuanliang , Wu Han , Li Zewen , Lin Jianli , Li Lingfei , Huang Xinghua , Chen Weiming , Chen Beibei 
Published: October 2024

Abstract
Abnormal power consumption pattern detection can effectively reduce the non-technical loss of electric energy, which is of great significance in maintaining the safe operation of the power grid and protecting the rights and interests of normal users. However, for edge environments with limited communication conditions, uploading electricity consumption data to the cloud for centralized computation is prone to problems such as network congestion and transmission delays. For this reason, this paper proposes a knowledge distillation (KD)-based anomalous power consumption pattern detection model that can be deployed at edge computing terminals. First, the ResNet50 network is selected as the teacher model, and the self-attention mechanism (SAM) is introduced to improve the feature extraction capability of long-term dependency. Then, ResNet18 is used as the student model, and the difference between the output of the student model and the output of the teacher model is minimized by optimizing the distillation loss function. Finally, the effectiveness of the proposed method is verified in practice.
Research and application of distributed photovoltaic precise dispatching and control technology
Authors: Song Xinxin , Wang Shitao , Wang Zhiqiang 
Published: October 2024

Abstract
With the continuous development of the electricity market, the scale of power terminal access continues to expand, and distributed photovoltaic collection and control strategies have become an important research hotspot. The article studies the grid-connected control technology of distributed photovoltaic power plants from grid-connected system architecture, the photovoltaic array operation mode selection, the grid-connected structure between photovoltaic groups, and the series-parallel scheme. It proposes an application method for precise regulation through distributed photovoltaic peak shaving.
Preliminary study of on-board handling of the blue swimming crabs in fisheries fleet
Authors: Wassahua Z , Zarochman  , Sasmita S , Sukoraharjo S S 
Published: October 2024

Abstract
The operation of the Blue Swimming Crab (BSC) fleet is one day trip not far from the coast, that the handling activity of BSC was carried out on land. Target fishing grounds in waters more than 30 meters depth. Preliminary assessment was carried out to determine the type of vessel, cooling system, and handling by steaming at pasteurization temperature, and BSC storage in order to improve the quality of BSC. The components of the BSC fishing facility unit that will be designed can be feasible and suitable for operational more than 3 up to 7-day trips in deeper waters and farther from the coast.
Export demand patterns for blue swimming crab from Indonesia to United States : impact of fishing seasons in FMA 712 (2018 to 2022)
Authors: Setioko W , Saputra SW , Wijayanto D , Sabdaningsih A 
Published: October 2024

Abstract
Blue swimming crab (Portunus pelagicus) is a significant fishery export commodity from Indonesia, especially the fisheries management area (FMA) 712. The aim of this study was to analyze the relationship between export demand and fishing season in FMA 712 during the last five years (2018–2022) based on export volume, prices, and fishing season information. Fishing season in Indonesia was classified as the west season with high rainfall (November to May) and the east season with low rainfall (June to October). The data were analyzed by correlation and trend analysis. The results showed that the export demand for blue swimming crab fluctuated with the fishing season. Demand for blue swimming crab tends to increase in the west season due to abundant supply from a favorable fishing season, leading to decreased prices due to international market competition. Conversely, demand for blue swimming crabs declines in the east season due to reduced supply from an unfavorable fishing season, resulting in increased prices due to limited availability. To address fluctuations, market diversification, product quality improvement, and sustainable fishery resource management are essential to balance profitable exports and marine preservation. Other variables that may influence export demand, such as global economic and political factors, were not included in this analysis.
Waste estimation and increased production of water spinach (Ipomoea reptans poir sp) in low salinity vannamei shrimp aquaponics cultivation
Authors: Fahrur M , Trijuno D D , Zainuddin  , Syah R 
Published: October 2024

Abstract
Low salinity aquaponics of vannamei shrimp and water spinach is an environmentally friendly cultivation method with the advantage of converting waste into high-value plants, land efficiency, clean water efficiency, and production of healthy food. This research aimed to calculate N and P waste from feed, which becomes shrimp, the role of water spinach in absorbing total N and total P at different shrimp densities and the same density. This research compared 3 treatments, namely Treatment A) shrimp density of 1,000 ind/m3 + 20 net pots of water spinach; B) 2,000 ind/m3 + 20 net pots of water spinach; and C) 3,000 ind/m3 + 20 netpots of water spinach. Shrimp were raised in containers measuring 70cm × 40 cm × 40 cm with a volume of 50 liter, while water spinach was grown in aquariums measuring 50 cm × 40 cm × 30 cm or a volume of 50 liter. In addition, shrimp were maintained for 70 days, and water spinach was subjected to two cycles with a maintenance period of 25 days per cycle. To support shrimp growth, feed with a protein content of 30-40% was also provided at a dosage of 10-5% of the biomass weight in the morning, afternoon, and evening. The results of the research on the combination of different shrimp densities and the same water spinach density showed that the higher the density of TN and TP waste shrimp, the higher the results were, so that the efficiency of the best water spinach plants in treatment A was with the highest shrimp productivity with the lowest N and P water quality.
Seasonal effects on blue swimming crab catch per unit effort (CPUE) in Tiworo Strait, Southeast Sulawesi, Indonesia
Authors: Cardin M , Welis M 
Published: October 2024

Abstract
Blue swimming crab (BSC) resources are fisheries commodities that have important economic value, so their utilization needs to be carried out sustainably. Understanding crab fishing season patterns is very important in efforts to improve the efficiency and effectiveness of crab fishing industry. This study aimed to analyze the abundance and catch per unit effort (CPUE) of blue swimming crab based on season in the the Tiworo Strait, Southeast Sulawesi, Indonesia. BSC sampling was conducted monthly from October 2022 to March 2023 (west season) and April to September 2023 (east season). The results showed that the maximum catch occurred during the east to west transition season, amounting to 1,668.50 kg, while the lowest catch was 376.70 kg with a total of 1,032 trips. The maximum catch in the west season was 1,402.10 kg, while the lowest was 666.50 kg with a total of 1,265 trips. The highest CPUE value was observed in July at 7.92 kg/trip, while the lowest CPUE occurred in April at 2.18 kg/trip. Differences in crab catches and number of trips in each season may be influenced by environmental conditions that occur in that season as well the location of the fishing ground.