bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prefer‐Oriented Ag2Se Crystal for High‐Performance Thermoelectric Cooling
Authors: Jiang Feng , Lin Chenhao , Cheng Jinxuan , Yu Hulei , Zhou Yifan , Ma Xiaojing , Wu Longzhi , Ye Sheng , Chen Jiang , Zhi Shizhen , Xu Yao , Zhao Peng , Wang Xiaodong , Cao Feng , Zhang Qian , Mao Jun 
Published: October 2024

AbstractAg2Se‐based materials with promising room‐temperature thermoelectric performance have been known for decades. However, thermoelectric cooling devices based on bulk Ag2Se have seldom been reported, mainly due to the phase transition ≈400 K poses a grand challenge for leg design and module integration. Herein, Ag2Se crystals with the preferred orientation have been prepared. A high carrier mobility of ≈1846 cm2 V−1 s−1 and a power factor of ≈31.2 µW cm−1 K−2 at room temperature has been realized, and results in a zT of ≈0.95 at 300 K. Importantly, by applying Ag as the contact layer, the Ag/Ag2Se/Ag joint has been prepared by one‐step sintering. By maintaining the pressure of ≈10 MPa after sintering and during the reflow soldering, the deleterious effect of the large thermal expansion can be alleviated. The contact resistance of the Ag/Ag2Se interface is as low as ≈2.9 µΩ cm2, indicating negligible electrical parasitic loss. The thermoelectric device with 7 pairs of Ag2Se and (Bi, Sb)2Te3 has been fabricated and it can achieve a maximum cooling power of ≈2.90 W and a cooling temperature difference of ≈70.4 K at the hot‐side temperature of 350 K, demonstrating the great potential of Ag2Se for cooling applications.
Hierarchical Nanowire Host Material for High‐Areal‐Capacity All‐Solid‐State S/SeS2 Batteries
Authors: Kim Hun , Choi Ha‐Neul , Kim Min‐Jae , Kansara Shivam , Kim Jun Tae , Shin Min‐Seok , Hwang Jang‐Yeon , Jung Hun‐Gi , Ming Jun , Sun Yang‐Kook 
Published: October 2024

AbstractAll‐solid‐state sulfur batteries (ASBs) suffer from electrical and ionic conduction problems due to the insulating sulfur. By comparing three host materials with different structural characteristics, herein, carbon nanotubes (CNTs) decorated with a conductive metal sulfide (CoMoS2@CNT) is demonstrated, designed to host sulfur and exchange both Li‐ions and electrons, effectively. In this hierarchical wire structure, porous CoMoS2 nanosheets form close interfaces with sulfur, and the CNT core directly transfers electrons to the sulfur‐impregnated CoMoS2. Simultaneously, the solid electrolyte positioned on the outer region of the nanowire material ensures facile Li‐ion conduction to the sulfur‐impregnated CoMoS2. An ASB featuring a CoMoS2@CNT host material with a sulfur loading of 3 mg cm−2 exhibits a high‐areal‐capacity of 4.5 mAh cm−2 at a current density of 2.5 mA cm−2, while retaining 79.4% of its initial capacity after 300 cycles. When sulfur is replaced with SeS2 to further reinforce the charge conduction properties, all‐solid‐state SeS2 batteries (ASeS2Bs) with an extremely high‐areal‐capacity of 16.3 mAh cm−2 retain 99.3% of their initial capacities after 60 cycles at 60 °C. This study provides guidelines for the design principles of cathode composites for the ASBs and ASeS2Bs through multiangle comparative analysis.
Chiral Quasi‐2D Perovskites Based Single Junction Spin‐Light‐Emitting Diodes
Authors: Li Binhe , Li Yang , Yuan Wei , Zhang Xiangpeng , Tao Sheng , Zhan Hongmei , Yu Zhi‐gang , Wang Kai , liu Jun , Wang Lixiang , Qin Chuanjiang 
Published: October 2024

AbstractLow temperature solution‐processible chiral metal halide perovskites, which posse the innately chiral‐induced spin orbit coupling (CISOC), are valuable for the realization of room temperature single junctions‐based spin‐light‐emitting diodes (spin‐LEDs), without involving integrated optics and ferromagnetic electrodes. The current challenging primarily lies on the development of high‐performance spin‐LEDs and the demonstration of the chiral‐induced spin selectivity (CISS). Herein, chiral organic cation based quasi‐2D perovskite films with prominently circularly polarized luminescence and bright emissions are fabricated for the application of room‐temperature spin‐LEDs. A remarkable external quantum efficiency (EQE) of 15.42% and circularly polarized electroluminescence (CP‐EL) of 4.98% are well achieved in ambient condition. With studies of spin‐related exciton states and magneto‐photoluminescence (magneto‐PL), the spin‐lifetime (τs) is estimated to be 20 ps. This work has greatly promoted the present growth for the high‐performance chiral perovskites spin‐LEDs.
Collaboration in Contradiction: Self‐Adaptive Synergistic ROS Generation and Scavenge Balancing Strategies Used for the Infected Wounds Treatment
Authors: Wang Mengtian , Liu Yangkun , Yang Shuqing , Wang Xuanbing , Duan Qindan , Liu Jiankai , Tan Xudong , Long Linjing , Liu Siyi , Xiao Yawen , Li Zhao , Han Changhao , Yi Yaoxing , Zhang Yuchan , Wang Guixue , Zang Guangchao 
Published: October 2024

AbstractThe rational utilization of ROS is key to treating infected wounds. Exogenous ROS can destroy bacterial structures, quickly kill bacteria, and inhibit secondary infections. However, excess ROS at the wound will cause a secondary inflammatory response. Acute infections exacerbate this damage by increasing endogenous ROS, complicating the maintenance of ROS homeostasis. Therefore, regulating the balance of ROS production and scavenging in wounds has emerged as a promising strategy for wound treatment. Conventional ROS balancing platforms are mostly based on the “ all for one” strategy of functional superposition and lack self‐adaptability and integration. To subvert this conventional strategy, this study proposes a “one for all” self‐adaptive integrated photodynamic therapy (PDT)‐antioxidant model to actively regulate the ROS balance. A gelatin‐hyaluronic acid hydrogel embedded with Se‐modified cerium dioxide nanoparticles (Gel‐HA‐Se@CeO2 NPs) is designed for treating infected wounds. The Se@CeO2 NPs serve both as nanoenzymes and photosensitizers(PS). As nanoenzymes, they exhibit catalase and superoxide dismutase activities, converting hydrogen peroxide and superoxide anions into oxygen. As a PS, it synergizes with oxygen under NIR irradiation to rapidly produce singlet oxygen. Additionally, Se modification enhances the PDT effects by disrupting bacterial antioxidant systems. In vitro and in vivo experiments revealed that the ROS balance platform polarizes M1‐type macrophages to M2‐type macrophages, altering the wound microenvironment from proinflammatory to prohealing. RNA sequencing revealed that this hydrogel accelerated the reconstruction of the vascular network of the wound by activating the PI3K/AKT pathway and increasing VEGF secretion.This strategy is believed to be beneficial not only for infected wounds but also for treating other conditions that involve the regulation of reactive oxygen species, such as tumors and bacterial infections.
Enhanced Thermal Conductivity and Stability of Hydrated Salt Phase Change Microcapsules With GO/SiO2 Hybrid Shell for Battery Thermal Management
Authors: Yuan Yingbiao , Wang Piao , Chen Mingfeng , Chen Renjie , Li Jun , Ju Haidong 
Published: October 2024

AbstractHerein, the synthesis of a novel microencapsulated phase change material via a sol–gel method is presented, featuring disodium hydrogen phosphate dodecahydrate as the core and a SiO2/graphene oxide composite as the shell. The morphology and core–shell microstructure of the synthesized microcapsules are characterized using scanning electron microscopy. The phase change performance and thermal stability are evaluated by differential scanning calorimetry and a high/low temperature test chamber, respectively. Energy dispersive X‐ray spectroscopy and Fourier transform infrared spectroscopy are employed to determine the chemical composition of the microcapsules. The findings reveal that the MEPCM exhibited a high melting enthalpy of 174.3 J g−1. The degree of supercooling is reduced by 2.1 °C, and after 600 thermal cycles, the phase change enthalpy of the microcapsules showed a minor decrease of ≈6.0%. Notably, the thermal conductivity of the microcapsules is significantly enhanced, increasing by up to 51.8%. When integrated into the thermal management systems of lithium‐ion batteries, the MEPCM effectively maintained the battery temperature below 46 °C under a 3 C charging rate. In summary, these results suggest that the hydrated salt microcapsule with its hybrid silica and graphene oxide shell is a promising material for the thermal management of lithium‐ion batteries.
Arylation of Secondary Phosphines with Diaryliodonium Salts under Metal‐Free and Non‐Photochemical Conditions
Authors: Jha Ajit Kumar , Sarkar Sudeep , Szczepanski Kacper , Kalek Marcin 
Published: October 2024

AbstractA metal‐ and irradiation‐free approach for the direct arylation of secondary phosphines has been developed. The reaction employs diaryliodonium salts as electrophilic aryl‐transfer reagents, effecting the P−Ar bond‐formation in a single step, under mild conditions, using t‐BuOK as a base and DMSO as a solvent. The protocol furnishes expedient access to diverse unsymmetrical triarylphosphines and, upon a one‐pot oxidation, the corresponding triarylphosphine oxides. Experimental and computational studies support the inner sphere aryl‐transfer mechanism through a reductive coupling at the hypervalent iodine center. The calculations also point to a key role played by potassium ions, providing extra stabilization to the P−C bond‐forming transition state by binding the reactants via cation‐π interactions.
Molybdenum‐Catalyzed Direct Synthesis of Pyrroles from Nitroarenes with Glycols as Reductants
Authors: Gómez‐Gil Sara , Suárez‐Pantiga Samuel , Pedrosa María R. , Sanz Roberto 
Published: October 2024

AbstractA molybdenum‐catalyzed synthesis of N‐(hetero)aryl pyrroles directly from inexpensive and commonly available (hetero)nitroarenes via reduction with pinacol and annulation with 1,4‐dicarbonyls or cyclobutane‐1,2‐diols has been described. The process does not require an inert atmosphere and tolerates the presence of air and water. This non‐noble catalytic system shows high chemoselectivity, allowing a diverse range of potentially reducible functional groups such as alkynes, alkenes, halogens, cyano, and carbonyls. Moreover, this strategy enables the reuse of a waste byproduct as reactant, facilitating the formation of challenging 1,4‐dicarbonyls from accessible cyclobutane‐1,2‐diols used as reducing agents.
Weed management in organic dryland wheat production in the Pacific Northwest
Authors: Burke Ian C. , Tautges Nicole E. , Manuchehri Misha R. , Fields Lydia S. 
Published: October 2024

AbstractGrowth in demand for organic small grains has increased interest in producing certified organic crops in the semiarid US Pacific Northwest. The region is well‐suited for small grain production, and there is a strong market for organic food products on the US West Coast. However, many growers encounter significant and persistent challenges with weed management, particularly management of perennial weeds such as Canada thistle [Cirsium arvense (L.) Scop.] and field bindweed (Convolvulus arvensis L.), but also common winter and spring annual grass weeds including cheatgrass (Bromus tectorum L.) and wild oat (Avena fatua L.). Coupled with the need to minimize soil disturbance, weed management can become nearly intractable and production limiting. From 2004 to 2024, several short and intermediate studies have been conducted to assess weed control tactics and crop rotation effects on weed management. Lessons learned include incorporating alfalfa (Medicago sativa L.) and spring barley (Hordeum vulgare L.) into rotations for suppression of field bindweed, or alfalfa and winter triticale (x Triticosecale Wittmack) for suppression of Canada thistle. Optimization of cultural inputs, particularly seeding rate, are critical for each crop in rotation. Animal integration and new crops such as quinoa (Chenopodium quinoa Willd.) are alternatives to conventional crops and potentially profitable. Incorporation of precision mechanical and chemical systems is feasible in narrow‐row cereals, and when combined with crop rotation, it could reduce or eliminate the need for repeated transitions back to convention production for organic growers.
Drought mediates Sphagnum defense response to herbivory
Authors: Chen Yong‐Da , Bu Zhao‐Jun , Wang Meng , Zhang Ming‐Ming , Ma Jin‐Ze , Guo Hong‐Bo 
Published: October 2024

AbstractPremiseThe expected concomitant increase in multiple stressors such as herbivory and drought may threaten peatland ecosystems. How Sphagnum, the ecological engineers of peatlands, responds to combined stressors remains largely unexplored. Here we aimed to clarify resource allocations in Sphagnum during concomitant herbivory and drought.MethodsS. magellanicum and S. fuscum were exposed to drought and herbivory together or separately in laboratory experiments and analyzed for growth (biomass production and net photosynthetic rate), defense (phenolics in leachates and phenolics in extraction) and nonstructural carbohydrates (soluble sugar and starch) in relation to untreated controls.ResultsHerbivory and drought had significant interactive effects on Sphagnum growth and defense. In both species, drought without herbivory reduced the phenolics in leachate, but with herbivory increased phenolics, indicating a synergistic effect between herbivory and drought on Sphagnum defense. Both stressors significantly decreased biomass production, with the combined stress having a more negative effect. Interestingly, a growth–defense trade‐off was found in the drought treatment of both Sphagnum species, but disappeared in the wet treatment. Conversely, a trade‐off between soluble sugars and phenolics was found in the wet but not in the drought treatment, suggesting that soluble sugars may play a role in inducing the defense and hence mask the growth–defense trade‐off in peat mosses.ConclusionsOur results emphasize that predicting the impact of combined stressors on peat moss traits is complex and challenging. Future models should account for the effects of multiple environmental stressors to guide peatland conservation under climate warming.
Second Report of the p.Leu874Pro Missense Variant in EPHB4 in a Family With Capillary Malformation‐Arteriovenous Malformation Syndrome (CM‐AVM) Syndrome
Authors: Goeser Laura E. , Lalor Leah , Chiu Yvonne E. , Muriello Michael 
Published: October 2024

ABSTRACTCapillary malformation‐arteriovenous malformation (CM‐AVM) syndrome is characterized by the presence of multiple small (1–2 cm in diameter) capillary malformations of the skin. This disorder has been described as two distinct entities: CM‐AVM1 and CM‐AVM2. The diagnosis of these disorders has been associated with pathogenic variants in the RASA1 gene for RASA1‐CM‐AVM, formerly known as CM‐AVM1, and, more recently, the EPHB4 genes for EPHB4‐CM‐AVM, formerly known as CM‐AVM2. Affected patients with either type may also have arteriovenous malformations and fistulas, which can cause life‐threatening bleeding, congestive heart failure, or neurologic consequences such as stroke. These syndromes are typically either sporadic or inherited in an autosomal dominant manner with variable expressivity. We report a case series of a father and three daughters who have clinically diagnosed EPHB4‐CM‐AVM syndrome who were found to have a variant of uncertain significance (VUS) in EPHB4 that has only been reported once prior.
Association of CSF α‐synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study
Authors: Tosun Duygu , Hausle Zachary , Thropp Pamela , Concha‐Marambio Luis , Lamoureux Jennifer , Lebovitz Russ , Shaw Leslie M. , Singleton Andrew B. , Weiner Michael W. ,   the Alzheimer's Disease Neuroimaging Initiative, Blauwendraat Cornelis 
Published: October 2024

AbstractINTRODUCTIONCerebrospinal fluid (CSF) α‐synuclein (α‐syn) seed amplification assay (SAA) is a sensitive and specific tool for detecting Lewy body co‐pathology in Alzheimer's disease.METHODSA total of 1637 cross‐sectional and 407 longitudinal CSF samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were tested with SAA. We examined longitudinal dynamics of amyloid beta (Aβ), α‐syn seeds, and phosphorylated tau181 (p‐tau181), along with global and domain‐specific cognition in stable SAA+, stable SAA−, and those who converted to SAA+ from SAA−.RESULTSSAA+ individuals had faster cognitive decline than SAA−, notably in mild cognitive impairment, and presented with earlier symptom onset. SAA+ conversion was associated with CSF Aβ42 positivity but did not impact the progression of either CSF Aβ42 or CSF p‐tau181 status. CSF Aβ42, p‐tau181, and α‐syn SAA were all strong predictors of clinical progression, particularly CSF Aβ42. In vitro, CSF α‐syn SAA kinetic parameters were associated with participant demographics, clinical profiles, and cognitive decline.DISCUSSIONThese results highlight the interplay between amyloid and α‐syn and their association with disease progression.Highlights
Seed amplification assay (SAA) positivity was associated with greater cognitive decline and earlier symptom onset.
Thirty‐four Alzheimer's Disease Neuroimaging Initiative (ADNI) individuals progressed from SAA− to SAA+, that is, ≈ 5% conversion.
SAA conversion was associated with amyloid beta (Aβ) pathology and greater cognitive decline.
SAA status did not impact the progression of either CSF Aβ42 or phosphorylated tau181 biomarkers.
Change in clinical diagnosis was associated with both Alzheimer's disease biomarkers and SAA.
SAA kinetic parameters were associated with clinical features and progression.
A Grafting Hydrogen‐bonded Organic Framework for Benchmark Selectivity of C2H2/CO2 Separation under Ambient Conditions
Authors: Yuan Furong , Li Yunbin , Yuan Zhen , Li Lu , Chen Chenxin , He Lei , Lin Hongyu , Fan Xi , Chen Banglin , Xiang Shengchang , Zhang Zhangjing 
Published: October 2024

AbstractReticular chemistry and pore engineering have garnered significant advancements in metal–organic frameworks and covalent organic frameworks, leveraging robust metal‐coordination and covalent bonds. However, these achievements remain elusive in hydrogen‐bonded organic frameworks, hindered by their inherent weakness in hydrogen bonding. Herein, we strategically manipulate the porosity of hydrogen‐bonded frameworks through a grafting approach, culminating in the synthesis of two isomorphic HOFs, HOF‐FJU‐99 and HOF‐FJU‐100, with distinct pore environments. Remarkably, HOF‐FJU‐100, with its microporous architecture, not only showcases exceptional stability but also achieves unparalleled separation efficiency and ultrahigh selectivity for C2H2/CO2 mixtures (50/50, v/v) under ambient conditions. Its IAST selectivity value of 201 stands as a benchmark, towering over all previously reported HOFs. The pore of HOF‐FJU‐100 boasts an electrostatic potential highly favourable for C2H2 adsorption, as evidenced by single crystal X‐ray diffraction analysis revealing multiple hydrogen bonding interactions between C2H2 molecules and the framework. In situ gas‐carrier powder X‐ray diffraction analysis underscores the adaptability of pore structure, dynamically adjusting its orientation in response to C2H2, thereby enabling a highly efficient and specific separation of C2H2/CO2 mixtures through specific adsorptive interactions.
Encapsulation of an Au25 Nanocluster inside a Porphyrin Nanoring Enhances Singlet Oxygen Generation and Photo‐Electrocatalytic CO2 Reduction
Authors: Ziarati Abolfazl , Gotfredsen Henrik , Rosspeintner Arnulf , Zhao Jiangtao , Anderson Harry L. , Bürgi Thomas 
Published: October 2024

AbstractThe synthesis of molecular host–guest complexes with enhanced performance, relative to those of their components, is a central theme in supramolecular chemistry. Here we explore a host‐guest system consisting of an atomically precise gold nanocluster bound inside a zinc porphyrin nanoring. UV/Vis absorption and fluorescence titrations with different sized nanorings revealed strong binding between a pyridinethiol‐coated Au25 nanocluster and a nanoring consisting of six zinc porphyrin units, and complexation is confirmed by mass spectrometry. Formation of this assembly enhances the stability of the gold nanocluster. The host‐guest complex also exhibits remarkable activity and selectivity for photochemical CO2 to CO conversion and singlet oxygen generation.
Targeting STAT3, FOXO3a, and Pim‐1 kinase by FDA‐approved tyrosine kinase inhibitor–Radotinib: An in silico and in vitro approach
Authors: Manoharan Suryaa , Santhakumar Aksayakeerthana , Perumal Ekambaram 
Published: October 2024

AbstractCancer, a multifactorial pathological condition, is primarily caused due to mutations in multiple genes. Hepatocellular carcinoma (HCC) is a form of primary liver cancer that is often diagnosed at the advanced stage. Current treatment strategies for advanced HCC involve systemic therapies which are often hindered due to the emergence of resistance and toxicity. Therefore, a multitarget approach might prove more effective in HCC treatment. The present study focuses on targeting signal transducer and activator of transcription 3 (STAT3), forkhead box class O3a (FOXO3a), and proviral integration site for Moloney murine leukemia virus‐1 (Pim‐1) kinase, using a Food and Drug Administration (FDA)‐approved anticancer drug library. Two compounds, namely, radotinib and capmatinib, were identified as top compounds using molecular docking. Among the two compounds, radotinib exhibited significant binding values towards the targeted proteins and their heterodimers. Furthermore, in vitro experiments involving 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT), live/dead, 4′,6‐diamidino‐2‐phenylindole, and clonogenic assays were performed to evaluate the effect of radotinib in human hepatoblastoma cell line/hepatocellular carcinoma cells. The gene expression data indicated reduced expression of FOXO3a and Pim‐1, but no basal‐level alteration of STAT3. The Western blot analysis assay showed that the phosphorylation level of STAT3 was significantly decreased upon radotinib treatment. Taken together, our findings suggest that radotinib, which is currently used in the treatment of chronic myeloid leukemia (CML), could be considered as a potential candidate for repurposing in the treatment of HCC.