bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE JUSTICIABILITY OF RELIGION
Authors: Juss Satvinder S. 
Published: October 2017

AbstractInShergill & Others v. Khaira & Others[2014] UKSC 33, the UK courts considered whether a Sikh holy saint had the power to dismiss trustees who questioned his “succession” to the religious institution of theNirmal Kutia Johal. The Supreme Court, reversing the decision of the Court of Appeal that religious questions were “nonjusticiable,” reinstated the judgment at first instance of the High Court to the contrary. The decision of the Supreme Court is important because whenever questions of the identification and legitimacy of successors to a religious institution have arisen, their “justiciability” before a secular court has invariably been a bone of contention on grounds that it threatens the autonomy of religious institutions. InShergillthe Supreme Court got around these concerns by drawing a normative distinction between the public law of the land (which the courts are required to determine), and the internal private law of a religious institution on matters of succession, ordination, and removal (which are not in themselves for the courts to decide). ButShergillalso went further than previous case law in two respects. First, the fundamental tenets of a belief system are capable of an objective assessment by a secular court provided that there is public law element to a dispute, in which case the court can then decide on the fitness of the successor for office. This means there is no general presumption that a secular court is barred from considering religious questions per se. Second, these principles apply just as much to the judicial consideration of non-Christian faiths as they to the Christian religion, and this is so notwithstanding the court's unfamiliarity with other faiths.
Aeolian silt contribution to soils on mountain slopes (Mt. Ślęża, southwest Poland)
Authors: Waroszewski Jaroslaw , Sprafke Tobias , Kabala Cezary , Musztyfaga Elżbieta , Łabaz Beata , Woźniczka Przemysław 
Published: October 2017

AbstractThis paper evaluates the possible contribution of aeolian silt to soils of Mt. Ślęża (southwest Poland). Silt loam textures are common across Lower Silesia and are often confused with silt clay loam, especially at the outer boundaries with thin loess deposits. Eight study sites with different thicknesses of silt loam mantles that are covered and/or mixed with underlying sediments were examined in the field. To test our hypothesis, we analyzed the particle size and geochemistry of representative horizons. Concentrations of major and trace elements as well as their cross ratios confirmed the aeolian origin of silt loam materials and clearly distinguished them from basal sediments. There is a clear relationship between the presence and depth of aeolian mantles and mixing zones with the type of underlying material. Furthermore, the incorporation of aeolian silt to regoliths/soils was a main agent initiating and stimulating clay translocation leading to the formation of an argic horizon below the silt mantles. Mixing aeolian silt with acid granite regoliths and further illuviation resulted in the formation of alisols, while silt contributions to serpentine sediments resulted in development of skeletic luvisols. Soils receiving very weak input of aeolian silts remain as leptosols/cambisols.
Heteromorphism in seeds ofLeptocereus scopulophilus(Cactaceae) from Pan de Matanzas, Cuba
Authors: García-Beltrán José Angel , Barrios Duniel , Cuza-Pérez Alina 
Published: October 2017

AbstractSeed heteromorphism is the formation of different seed morphs from the same individual. Two seed morphs have been preliminarily observed inLeptocereus scopulophilus. One morph shows an apparent natural scarification of its coat. Herein we describe the seeds, taking into account shape, coat integrity, surface, dimensions, mass and the position of germination cracks. We defined two seed morphs using the integrity of the spermoderma: fragmented seed coats (FSC) and complete seed coats (CSC). We also evaluated minimum germination time, germination rate and germinability. The seed morphs did not differ significantly in traits; however, regular striations along the cuticle of the periclinal walls were more visible in the FSC compared with the CSC. Both seed morphs displayed anticlinal cell boundaries in the border region that are channelled and straight in the dorsal-ventral region but difficult to define in the lateral region. We found four morphological variations in different positions where the radicle or cotyledons emerge and variations in cuticle thickness in different regions of the seed that could determine the formation of cracks during germination. All germination variants occurred in both seed morphs, albeit in different proportions. Germination was higher and faster for the FSC compared with the CSC. These germination differences could be related to a thinner cuticle in the FSC and the punctual release of its spermoderma, which facilitates a quick imbibition of the embryo and the breaking of the seed coat. Our results indicate that differences in germination parameters between the two seed morphs relate to differences in the percentage of dormant seeds, which favour the temporal expansion of germination and reduce competition between siblings. To propagate the species for conservation purposes, we recommend using FSC, while CSC may be used to establish a seed collectionex situ.
Neuropsychological Assessment at Preschool Age: Adaptation and Validation of the McCarthy Scales of Children’s Abilities to 4 Year-old Basque-speaking Children
Authors: Andiarena Ainara , Balluerka Nekane , Gorostiaga Arantxa , Ibarluzea Jesús 
Published: October 2017

AbstractEarly neuropsychological assessment provides important information for clinical practice and research. As previously no tool for neuropsychological assessment has been developed in or adapted to Basque, the aim of this study was to adapt and validate the McCarthy Scales of Children’s Abilities for 4 years old children. The adaptation and validation of the original instrument followed the methodological steps established by the International Test Commission. We examined the psychometric properties of the adapted instrument in 273 Basque preschool children (aged between 4 years and 4 months and 4 years and 11 months; 52.2% boys). Confirmatory factor analysis showed satisfactory fit indexes except for the General Cognitive and Memory scales. Most scales presented adequate internal consistency (Reliability coefficients ranged between .55 and .81). The Basque version also showed evidence of validity based on the relationship between neuropsychological development and sex, parental education, attention deficit hyperactivity disorder-like behaviours and early neurodevelopment (p < .05; effect sizes ranged between Cohen’s d = .26 and .52 and r = .15 and 39). The Basque MSCA can be regarded as a useful tool to evaluate cognitive and psychomotor development in preschool children.
Precision cosmology from future lensed gravitational wave and electromagnetic signals
Authors: Liao Kai , Fan Xi-Long , Ding Xuheng , Biesiada Marek , Zhu Zong-Hong 
Published: October 2017

AbstractThe standard siren approach of gravitational wave cosmology appeals to the direct luminosity distance estimation through the waveform signals from inspiralling double compact binaries, especially those with electromagnetic counterparts providing redshifts. It is limited by the calibration uncertainties in strain amplitude and relies on the fine details of the waveform. The Einstein telescope is expected to produce 104–105 gravitational wave detections per year, 50–100 of which will be lensed. Here, we report a waveform-independent strategy to achieve precise cosmography by combining the accurately measured time delays from strongly lensed gravitational wave signals with the images and redshifts observed in the electromagnetic domain. We demonstrate that just 10 such systems can provide a Hubble constant uncertainty of 0.68% for a flat lambda cold dark matter universe in the era of third-generation ground-based detectors.
The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency
Authors: Yu Chun-Ying , Li Tung-Cheng , Wu Yi-Ying , Yeh Chan-Hsien , Chiang Wei , Chuang Ching-Yu , Kuo Hung-Chih 
Published: October 2017

AbstractAccumulating evidence indicates that circular RNAs (circRNAs) are abundant in the human transcriptome. However, their involvement in biological processes, including pluripotency, remains mostly undescribed. We identified a subset of circRNAs that are enriched in undifferentiated human embryonic stem cells (hESCs) and demonstrated that two, circBIRC6 and circCORO1C, are functionally associated with the pluripotent state. Mechanistically, we found that circBIRC6 is enriched in the AGO2 complex and directly interacts with microRNAs, miR-34a, and miR-145, which are known to modulate target genes that maintain pluripotency. Correspondingly, circBIRC6 attenuates the downregulation of these target genes and suppresses hESC differentiation. We further identified hESC-enriched splicing factors (SFs) and demonstrated that circBIRC6 biogenesis in hESCs is promoted by the SF ESRP1, whose expression is controlled by the core pluripotency-associated factors, OCT4 and NANOG. Collectively, our data suggest that circRNA serves as a microRNA “sponge” to regulate the molecular circuitry, which modulates human pluripotency and differentiation.
Exciton fission in monolayer transition metal dichalcogenide semiconductors
Authors: Steinhoff A. , Florian M. , Rösner M. , Schönhoff G. , Wehling T. O. , Jahnke F. 
Published: October 2017

AbstractWhen electron-hole pairs are excited in a semiconductor, it is a priori not clear if they form a plasma of unbound fermionic particles or a gas of composite bosons called excitons. Usually, the exciton phase is associated with low temperatures. In atomically thin transition metal dichalcogenide semiconductors, excitons are particularly important even at room temperature due to strong Coulomb interaction and a large exciton density of states. Using state-of-the-art many-body theory, we show that the thermodynamic fission–fusion balance of excitons and electron-hole plasma can be efficiently tuned via the dielectric environment as well as charge carrier doping. We propose the observation of these effects by studying exciton satellites in photoemission and tunneling spectroscopy, which present direct solid-state counterparts of high-energy collider experiments on the induced fission of composite particles.
Van der Waals MoS2/VO2 heterostructure junction with tunable rectifier behavior and efficient photoresponse
Authors: Oliva Nicoló , Casu Emanuele Andrea , Yan Chen , Krammer Anna , Rosca Teodor , Magrez Arnaud , Stolichnov Igor , Schueler Andreas , Martin Olivier J. F. , Ionescu Adrian Mihai 
Published: October 2017

AbstractJunctions between n-type semiconductors of different electron affinity show rectification if the junction is abrupt enough. With the advent of 2D materials, we are able to realize thin van der Waals (vdW) heterostructures based on a large diversity of materials. In parallel, strongly correlated functional oxides have emerged, having the ability to show reversible insulator-to-metal (IMT) phase transition by collapsing their electronic bandgap under a certain external stimulus. Here, we report for the first time the electronic and optoelectronic characterization of ultra-thin n-n heterojunctions fabricated using deterministic assembly of multilayer molybdenum disulphide (MoS2) on a phase transition material, vanadium dioxide (VO2). The vdW MoS2/VO2 heterojunction combines the excellent blocking capability of an n-n junction with a high conductivity in on-state, and it can be turned into a Schottky rectifier at high applied voltage or at temperatures higher than 68 °C, exploiting the metal state of VO2. We report tunable diode-like current rectification with a good diode ideality factor of 1.75 and excellent conductance swing of 120 mV/dec. Finally, we demonstrate unique tunable photosensitivity and excellent junction photoresponse in the 500/650 nm wavelength range.
Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells
Authors: Khalil Andrew S. , Yu Xiaohua , Xie Angela W. , Fontana Gianluca , Umhoefer Jennifer M. , Johnson Hunter J. , Hookway Tracy A. , McDevitt Todd C. , Murphy William L. 
Published: October 2017

AbstractGene delivery to primary human cells is a technology of critical interest to both life science research and therapeutic applications. However, poor efficiencies in gene transfer and undesirable safety profiles remain key limitations in advancing this technology. Here, we describe a materials-based approach whereby application of a bioresorbable mineral coating improves microparticle-based transfection of plasmid DNA lipoplexes in several primary human cell types. In the presence of these mineral-coated microparticles (MCMs), we observed up to 4-fold increases in transfection efficiency with simultaneous reductions in cytotoxicity. We identified mechanisms by which MCMs improve transfection, as well as coating compositions that improve transfection in three-dimensional cell constructs. The approach afforded efficient transfection in primary human fibroblasts as well as mesenchymal and embryonic stem cells for both two- and three-dimensional transfection strategies. This MCM-based transfection is an advancement in gene delivery technology, as it represents a non-viral approach that enables highly efficient, localized transfection and allows for transfection of three-dimensional cell constructs.
Genetic and phenotypic characterization of the novel mouse substrain C57BL/6N Korl with increased body weight
Authors: Choi Kyung-Min , Jung Jaehoon , Cho Young Min , Kim Kwondo , Kim Mi-Gyeong , Kim Jinho , Kim Huibae , Shin Hee Jung , Kim Hae Deun , Chung Seung-Tae , Cho Seoae , Chung Myeon-Woo 
Published: October 2017

AbstractIn inbred mouse lines, there is generally little genetic difference between individuals. This small genetic variability facilitates carrying out research on minute changes of various traits and the gene pool. Also, characterizing the diversity and detecting selective genetic and phenotypic signatures are crucial to understanding the genomic basis of a population and to identify specific patterns of evolutionary change. In this study, we investigated the underlying genetic profiles of a newly developed mouse strain, C57BL/6NKorl (Korl), established through sibling mating over 30 generations. To analyse the distinctive genomic features of Korl mice, we used whole-genome sequencing from six samples, which were compared to those of other C57BL/6N-based mouse strains. Korl strain-specific polymorphisms were identified and signatures of a selective sweep were detected. In particular, the candidate genes related to the increased body weight of the Korl strain were identified. Establishment of the genetic profile of Korl mice can provide insight into the inbreeding-induced changes to the gene pool, and help to establish this strain as a useful model for practical and targeted research purposes.
Self-propulsion of a grain-filled dimer in a vertically vibrated channel
Authors: Xu C. , Zheng N. , Wang L.-P. , Li L.-S. , Shi Q.-F. , Lu Zhiyue 
Published: October 2017

AbstractSteady dissipation of energy is a crucial property that distinguishes active particles from Brownian particles. However, it is not straightforward to explicitly model the dissipative property of existing active particles driven by a vibrating plate. We present a novel active particle that can be explicitly modeled by Newtonian dynamics of a conservative force field plus two asymmetrical dissipative terms. The particle is a dimer consisting of two ping-pong balls connected by a rigid rod, and its two balls are filled with granular particles of the same total mass but of different grain size. This dimer placed on a vibrating plate exhibits 3 types of motion – by tuning the frequency and the amplitude of the vibration, the dimer undergoes either a directed motion toward the small (or large) grain-filled side or an unbiased random motion. We investigate the various modes of motion both experimentally and numerically and show that the directed motion is a result of the asymmetric damping due to the size difference in the filling grains. Furthermore, the numerical simulation reveals that the dimer’s dynamics in either directed motion mode resembles a limit cycle attractor that is independent of its initial condition.
Differential inter-subject correlation of brain activity when kinship is a variable in moral dilemma
Authors: Bacha-Trams Mareike , Glerean Enrico , Dunbar Robin , Lahnakoski Juha M. , Ryyppö Elisa , Sams Mikko , Jääskeläinen Iiro P. 
Published: October 2017

AbstractPrevious behavioural studies have shown that humans act more altruistically towards kin. Whether and how knowledge of genetic relatedness translates into differential neurocognitive evaluation of observed social interactions has remained an open question. Here, we investigated how the human brain is engaged when viewing a moral dilemma between genetic vs. non-genetic sisters. During functional magnetic resonance imaging, a movie was shown, depicting refusal of organ donation between two sisters, with subjects guided to believe the sisters were related either genetically or by adoption. Although 90% of the subjects self-reported that genetic relationship was not relevant, their brain activity told a different story. Comparing correlations of brain activity across all subject pairs between the two viewing conditions, we found significantly stronger inter-subject correlations in insula, cingulate, medial and lateral prefrontal, superior temporal, and superior parietal cortices, when the subjects believed that the sisters were genetically related. Cognitive functions previously associated with these areas include moral and emotional conflict regulation, decision making, and mentalizing, suggesting more similar engagement of such functions when observing refusal of altruism from a genetic sister. Our results show that mere knowledge of a genetic relationship between interacting persons robustly modulates social cognition of the perceiver.
Entanglement-Gradient Routing for Quantum Networks
Authors: Gyongyosi Laszlo , Imre Sandor 
Published: October 2017

AbstractWe define the entanglement-gradient routing scheme for quantum repeater networks. The routing framework fuses the fundamentals of swarm intelligence and quantum Shannon theory. Swarm intelligence provides nature-inspired solutions for problem solving. Motivated by models of social insect behavior, the routing is performed using parallel threads to determine the shortest path via the entanglement gradient coefficient, which describes the feasibility of the entangled links and paths of the network. The routing metrics are derived from the characteristics of entanglement transmission and relevant measures of entanglement distribution in quantum networks. The method allows a moderate complexity decentralized routing in quantum repeater networks. The results can be applied in experimental quantum networking, future quantum Internet, and long-distance quantum communications.
Male fertility restored by transplanting primordial germ cells into testes: a new way towards efficient transgenesis in chicken
Authors: Trefil Pavel , Aumann Dorothea , Koslová Anna , Mucksová Jitka , Benešová Barbora , Kalina Jiří , Wurmser Christine , Fries Ruedi , Elleder Daniel , Schusser Benjamin , Hejnar Jiří 
Published: October 2017

AbstractThe ongoing progress in primordial germ cell derivation and cultivation is opening new ways in reproductive biotechnology. This study tested whether functional sperm cells can be matured from genetically manipulated primordial germ cells after transplantation in adult testes and used to restore fertility. We show that spermatogenesis can be restored after mCherry-expressing or GFP-expressing primordial germ cells are transplantated into the testes of sterilized G0 roosters and that mCherry-positive or GFP-positive non-chimeric transgenic G1 offspring can be efficiently produced. Compared with the existing approaches to primordial germ cell replacement, this new technique eliminates the germ line chimerism of G0 roosters and is, therefore, faster, more efficient and requires fewer animals. Furthermore, this is the only animal model, where the fate of primordial germ cells in infertile recipients can be studied.
In Vitro Seamless Stack Enzymatic Assembly of DNA Molecules Based on a Strategy Involving Splicing of Restriction Sites
Authors: Yu Dong , Tan Yanning , Sun Zhizhong , Sun Xuewu , Sheng Xiabing , Zhou Tianshun , Liu Ling , Mo Yi , Jiang Beibei , Ouyang Ning , Yin Xiaolin , Duan Meijuan , Yuan Dingyang 
Published: October 2017

AbstractThe standard binary enzymatic assembly, which operates by inserting one DNA fragment into a plasmid, has a higher assembly success rate than the polynary enzymatic assembly, which inserts two or more fragments into the plasmid. However, it often leaves a nucleotide scar at the junction site. When a large DNA molecule is assembled stepwise into a backbone plasmid in a random piecewise manner, the scars will damage the structure of the original DNA sequence in the final assembled plasmids. Here, we propose an in vitro Seamless Stack Enzymatic Assembly (SSEA) method, a novel binary enzymatic assembly method involving a seamless strategy of splicing restriction sites via a stepwise process of multiple enzymatic reactions that does not leave nucleotide scars at the junction sites. We have demonstrated the success and versatility of this method through the assembly of 1) a 4.98 kb DNA molecule in the 5′ → 3′ direction using BamHI to generate the sticky end of the assembly entrance, 2) a 7.09 kb DNA molecule in the 3′ → 5′ direction using SmaI to generate the blunt end of the assembly entrance, and 3) an 11.88 kb DNA molecule by changing the assembly entrance.
Complementary mechanisms for neurotoxin resistance in a copepod
Authors: Roncalli Vittoria , Lenz Petra H. , Cieslak Matthew C. , Hartline Daniel K. 
Published: October 2017

AbstractToxin resistance is a recurring evolutionary response by predators feeding on toxic prey. These adaptations impact physiological interaction and community ecology. Mechanisms for resistance vary depending on the predator and the nature of the toxin. Potent neurotoxins like tetrodotoxin (TTX) and saxitoxin (STX) that are highly toxic to humans and other vertebrates, target conserved voltage-gated sodium channels (NaV) of nerve and muscle, causing paralysis. The copepod Calanus finmarchicus consumes the STX-producing dinoflagellate, Alexandrium fundyense with no effect on survival. Using transcriptomic approaches to search for the mechanism that confers resistance in C. finmarchicus, we identified splice variants of NaVs that were predicted to be toxin resistant. These were co-expressed with putatively non-resistant form in all developmental stages. However its expression was unresponsive to toxin challenge nor was there any up-regulation of genes involved in multi-xenobiotic resistance (MXR) or detoxification (phases I or II). Instead, adults consistently regulated genes encoding digestive enzymes, possibly to complement channel resistance by limiting toxin assimilation via the digestive process. The nauplii, which were more susceptible to STX, did not regulate these enzymes. This study demonstrates how deep-sequencing technology can elucidate multiple mechanisms of toxin resistance concurrently, revealing the linkages between molecular/cellular adaptations and the ecology of an organism.