bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterisation of the Groningen subsurface for seismic hazard and risk modelling
Authors: Kruiver Pauline P. , Wiersma Ane , Kloosterman Fred H. , de Lange Ger , Korff Mandy , Stafleu Jan , Busschers Freek S. , Harting Ronald , Gunnink Jan L. , Green Russell A. , van Elk Jan , Doornhof Dirk 
Published: January 2018

AbstractThe shallow subsurface of Groningen, the Netherlands, is heterogeneous due to its formation in a Holocene tidal coastal setting on a periglacially and glacially inherited landscape with strong lateral variation in subsurface architecture. Soft sediments with low, small-strain shear wave velocities (VS30around 200 m s−1) are known to amplify earthquake motions. Knowledge of the architecture and properties of the subsurface and the combined effect on the propagation of earthquake waves is imperative for the prediction of geohazards of ground shaking and liquefaction at the surface. In order to provide information for the seismic hazard and risk analysis, two geological models were constructed. The first is the ‘Geological model for Site response in Groningen’ (GSG model) and is based on the detailed 3D GeoTOP voxel model containing lithostratigraphy and lithoclass attributes. The GeoTOP model was combined with information from boreholes, cone penetration tests, regional digital geological and geohydrological models to cover the full range from the surface down to the base of the North Sea Supergroup (base Paleogene) at ~800 m depth. The GSG model consists of a microzonation based on geology and a stack of soil stratigraphy for each of the 140,000 grid cells (100 m × 100 m) to which properties (VSand parameters relevant for nonlinear soil behaviour) were assigned. The GSG model serves as input to the site response calculations that feed into the Ground Motion Model. The second model is the ‘Geological model for Liquefaction sensitivity in Groningen’ (GLG). Generally, loosely packed sands might be susceptible to liquefaction upon earthquake shaking. In order to delineate zones of loosely packed sand in the first 40 m below the surface, GeoTOP was combined with relative densities inferred from a large cone penetration test database. The marine Naaldwijk and Eem Formations have the highest proportion of loosely packed sand (31% and 38%, respectively) and thus are considered to be the most vulnerable to liquefaction; other units contain 5–17% loosely packed sand. The GLG model serves as one of the inputs for further research on the liquefaction potential in Groningen, such as the development of region-specific magnitude scaling factors (MSF) and depth–stress reduction relationships (rd).
Development of seismicity and probabilistic hazard assessment for the Groningen gas field
Authors: Dost Bernard , Ruigrok Elmer , Spetzler Jesper 
Published: January 2018

AbstractThe increase in number and strength of shallow induced seismicity connected to the Groningen gas field since 2003 and the occurrence of aML3.6 event in 2012 started the development of a full probabilistic seismic hazard assessment (PSHA) for Groningen, required by the regulator. Densification of the monitoring network resulted in a decrease of the location threshold and magnitude of completeness down to ~ML=0.5. Combined with a detailed local velocity model, epicentre accuracy could be reduced from 0.5–1km to 0.1–0.3km and a vertical resolution ~0.3km. Time-dependent seismic activity is observed and taken into account into PSHA calculations. Development of the Ground Motion Model for Groningen resulted in a significant reduction of the hazard. Comparison of different implementations of the PSHA, using different source models, based on either a compaction model and production scenarios or on extrapolation of past seismicity, and methods of calculation, shows similar results.
Fault reactivation mechanisms and dynamic rupture modelling of depletion-induced seismic events in a Rotliegend gas reservoir
Authors: Buijze Loes , van den Bogert Peter A.J. , Wassing Brecht B.T. , Orlic Bogdan , ten Veen Johan 
Published: January 2018

AbstractUnderstanding the mechanisms and key parameters controlling depletion-induced seismicity is key for seismic hazard analyses and the design of mitigation measures. In this paper a methodology is presented to model in 2D the static stress development on faults offsetting depleting reservoir compartments, reactivation of the fault, nucleation of seismic instability, and the subsequent fully dynamic rupture including seismic fault rupture and near-field wave propagation. Slip-dependent reduction of the fault's strength (cohesion and friction) was used to model the development of the instability and seismic rupture. The inclusion of the dynamic calculation allows for a closer comparison to field observables such as borehole seismic data compared to traditional static geomechanical models. We applied this model procedure to a fault and stratigraphy typical for the Groningen field, and compared the results for an offset fault to a fault without offset. A non-zero offset on the fault strongly influenced the stress distribution along the fault due to stress concentrations in the near-fault area close to the top of the hanging wall and the base of the footwall. The heterogeneous stress distribution not only controlled where nucleation occurred within the reservoir interval, but also influenced the subsequent propagation of seismic rupture with low stresses inhibiting the propagation of slip. In a reservoir without offset the stress distribution was relatively uniform throughout the reservoir depth interval. Reactivation occurred at a much larger pressure decrease, but the subsequent seismic event was much larger due to the more uniform state of stress within the reservoir. In both cases the models predicted a unidirectional downward-propagating rupture, with the largest wave amplitudes being radiated downwards into the hanging wall. This study showed how a realistic seismic event could be successfully modelled, including the depletion-induced stressing, nucleation, dynamic propagation, and wave propagation. The influence of fault offset on the depletion-induced stress is significant; the heterogeneous stress development along offset faults not only strongly controls the timing and location of a seismic slip, but also influences the subsequent rupture size of the dynamic event.
Maternal early pregnancy obesity and depressive symptoms during and after pregnancy
Authors: Kumpulainen Satu M. , Girchenko Polina , Lahti-Pulkkinen Marius , Reynolds Rebecca M. , Tuovinen Soile , Pesonen Anu-Katriina , Heinonen Kati , Kajantie Eero , Villa Pia M. , Hämäläinen Esa , Laivuori Hannele , Räikkönen Katri 
Published: January 2018

AbstractBackgroundPrevious studies have linked maternal obesity with depressive symptoms during and after pregnancy. It remains unknown whether obesity associates with consistently elevated depressive symptoms throughout pregnancy, predicts symptoms postpartum when accounting for antenatal symptoms, and if co-morbid hypertensive and diabetic disorders add to these associations. We addressed these questions in a sample of Finnish women whom we followed during and after pregnancy.MethodsEarly pregnancy body mass index, derived from the Finnish Medical Birth Register and hospital records in 3234 PREDO study participants, was categorized into underweight (<18.5 kg/m2), normal weight (18.5–24.99 kg/m2), overweight (25–29.99 kg/m2), and obese (⩾30 kg/m2) groups. The women completed the Center for Epidemiological Studies Depression Scale biweekly during pregnancy, and at 2.4 (s.d.= 1.2) and/or 28.2 (s.d.= 4.2) weeks after pregnancy.ResultsIn comparison to normal weight women, overweight, and obese women reported higher levels of depressive symptoms and had higher odds of clinically significant depressive symptoms during (23% and 43%, respectively) and after pregnancy (22% and 36%, respectively). Underweight women had 68% higher odds of clinically significant depressive symptoms after pregnancy. Overweight and obesity also predicted higher depressive symptoms after pregnancy in women not reporting clinically relevant symptomatology during pregnancy. Hypertensive and diabetic disorders did not explain or add to these associations.ConclusionsMaternal early pregnancy overweight and obesity and depressive symptoms during and after pregnancy are associated. Mental health promotion should be included as an integral part of lifestyle interventions in early pregnancy obesity and extended to benefit also overweight and underweight women.
Population dynamics of the cashew leafminer, Eteoryctis gemoniella (Lepidoptera: Gracillariidae), and inventory of its parasitoids in cashew orchards of Northern Benin, West Africa
Authors: Agboton Cyriaque , Onzo Alexis , Akohou Hermine A. , Goergen Georg , Vidal Stefan , Tamò Manuele 
Published: January 2018

AbstractIn this study, we investigate the spatio-temporal fluctuations of the cashew leafminer Eteoryctis gemoniella Stainton, which was recently reported as one of the most devastating cashew pests in Benin. Eteoryctis gemoniella causes serious damage, especially to the young tender leaves, thus reducing the photosynthetic capacity of trees and hence their productivity. This study was carried out in three different cashew orchards in Northern Benin, West Africa, where we monitored the fluctuations of the infestation rates and population changes of E. gemoniella during a one-year cycle, from September 2010 to August 2011. In addition, we collected cashew leaves with mines to check for emergence of hymenopteran parasitoids. Our results show that infestation rates (as well as population densities of E. gemoniella) varied through time and among orchards. The most infested orchard was at Korou, whereas, the least infested was at Okoutaossé. In general, infestation rates and number of mines per leaf passed through two peaks, the first in July–August and the second in November, whereas no infestations were observed from January to June. Spatial distribution pattern of E. gemoniella within the orchards showed that this moth almost has a random distribution. Parasitoids attacking the leafminer were recovered from the samples. These were Apanteles sp., Chelonus (Microchelonus) nr. curvimaculatus Cameron (Hymenoptera: Braconidae) and Trathala sp. (Hymenoptera: Ichneumonidae). Further detailed studies on these natural enemies will be needed for evaluating their potential in controlling E. gemoniella in cashew orchards.
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population
Authors: Yousri Noha A. , Fakhro Khalid A. , Robay Amal , Rodriguez-Flores Juan L. , Mohney Robert P. , Zeriri Hassina , Odeh Tala , Kader Sara Abdul , Aldous Eman K. , Thareja Gaurav , Kumar Manish , Al-Shakaki Alya , Chidiac Omar M. , Mohamoud Yasmin A. , Mezey Jason G. , Malek Joel A. , Crystal Ronald G. , Suhre Karsten 
Published: January 2018

AbstractMetabolomics-genome-wide association studies (mGWAS) have uncovered many metabolic quantitative trait loci (mQTLs) influencing human metabolic individuality, though predominantly in European cohorts. By combining whole-exome sequencing with a high-resolution metabolomics profiling for a highly consanguineous Middle Eastern population, we discover 21 common variant and 12 functional rare variant mQTLs, of which 45% are novel altogether. We fine-map 10 common variant mQTLs to new metabolite ratio associations, and 11 common variant mQTLs to putative protein-altering variants. This is the first work to report common and rare variant mQTLs linked to diseases and/or pharmacological targets in a consanguineous Arab cohort, with wide implications for precision medicine in the Middle East.
Lack of beta-arrestin signaling in the absence of active G proteins
Authors: Grundmann Manuel , Merten Nicole , Malfacini Davide , Inoue Asuka , Preis Philip , Simon Katharina , Rüttiger Nelly , Ziegler Nicole , Benkel Tobias , Schmitt Nina Katharina , Ishida Satoru , Müller Ines , Reher Raphael , Kawakami Kouki , Inoue Ayumi , Rick Ulrike , Kühl Toni , Imhof Diana , Aoki Junken , König Gabriele M. , Hoffmann Carsten , Gomeza Jesus , Wess Jürgen , Kostenis Evi 
Published: January 2018

AbstractG protein-independent, arrestin-dependent signaling is a paradigm that broadens the signaling scope of G protein-coupled receptors (GPCRs) beyond G proteins for numerous biological processes. However, arrestin signaling in the collective absence of functional G proteins has never been demonstrated. Here we achieve a state of “zero functional G” at the cellular level using HEK293 cells depleted by CRISPR/Cas9 technology of the Gs/q/12 families of Gα proteins, along with pertussis toxin-mediated inactivation of Gi/o. Together with HEK293 cells lacking β-arrestins (“zero arrestin”), we systematically dissect G protein- from arrestin-driven signaling outcomes for a broad set of GPCRs. We use biochemical, biophysical, label-free whole-cell biosensing and ERK phosphorylation to identify four salient features for all receptors at “zero functional G”: arrestin recruitment and internalization, but—unexpectedly—complete failure to activate ERK and whole-cell responses. These findings change our understanding of how GPCRs function and in particular of how they activate ERK1/2.
Spectral mapping of brain functional connectivity from diffusion imaging
Authors: Becker Cassiano O. , Pequito Sérgio , Pappas George J. , Miller Michael B. , Grafton Scott T. , Bassett Danielle S. , Preciado Victor M. 
Published: January 2018

AbstractUnderstanding the relationship between the dynamics of neural processes and the anatomical substrate of the brain is a central question in neuroscience. On the one hand, modern neuroimaging technologies, such as diffusion tensor imaging, can be used to construct structural graphs representing the architecture of white matter streamlines linking cortical and subcortical structures. On the other hand, temporal patterns of neural activity can be used to construct functional graphs representing temporal correlations between brain regions. Although some studies provide evidence that whole-brain functional connectivity is shaped by the underlying anatomy, the observed relationship between function and structure is weak, and the rules by which anatomy constrains brain dynamics remain elusive. In this article, we introduce a methodology to map the functional connectivity of a subject at rest from his or her structural graph. Using our methodology, we are able to systematically account for the role of structural walks in the formation of functional correlations. Furthermore, in our empirical evaluations, we observe that the eigenmodes of the mapped functional connectivity are associated with activity patterns associated with different cognitive systems.
Ag-migration effects on the metastable phase in CaCu3Ti4O12 capacitors
Authors: Lee Ji-Won , Lee Gun-Hyun , Shin Dong-Jin , Kim Jinhwan , Jeong Soon-Jong , Koh Jung-Hyuk 
Published: January 2018

AbstractThe silver migration effect into the metastable phase forms a micro-electric path, to enhance the relative dielectric permittivity of CaCu3Ti4O12 ceramics for electronic devices. Controlling the sintering time uniquely develops the metastable phase of as-sintered CaCu3Ti4O12 ceramics. A post-heating process that applies the migration of silver into the metastable phase increases the relative dielectric permittivity. At 1 kHz frequency, the relative dielectric permittivity at room temperature of the silver-migrated CaCu3Ti4O12 ceramics sintered for 2 h is 565.9 × 103, almost 52 times higher than that of the as-sintered CaCu3Ti4O12 ceramics. The selected area electron diffraction (SAED) patterns of the large and small grains were similar, but differed from those of the metastable region, including the grain boundary of the as-sintered CaCu3Ti4O12 ceramics sintered for 2 h by TEM technique. This phenomenon suggests that enabling Ag-migration into the metastable phase develops a micro-electric path that improves the relative dielectric permittivity of CaCu3Ti4O12 ceramics.
Random neuronal ensembles can inherently do context dependent coarse conjunctive encoding of input stimulus without any specific training
Authors: George Jude Baby , Abraham Grace Mathew , Rashid Zubin , Amrutur Bharadwaj , Sikdar Sujit Kumar 
Published: January 2018

AbstractConjunctive encoding of inputs has been hypothesized to be a key feature in the computational capabilities of the brain. This has been inferred based on behavioral studies and electrophysiological recording from animals. In this report, we show that random neuronal ensembles grown on multi-electrode array perform a coarse-conjunctive encoding for a sequence of inputs with the first input setting the context. Such an encoding scheme creates similar yet unique population codes at the output of the ensemble, for related input sequences, which can then be decoded via a simple perceptron and hence a single STDP neuron layer. The random neuronal ensembles allow for pattern generalization and novel sequence classification without needing any specific learning or training of the ensemble. Such a representation of the inputs as population codes of neuronal ensemble outputs, has inherent redundancy and is suitable for further decoding via even probabilistic/random connections to subsequent neuronal layers. We reproduce this behavior in a mathematical model to show that a random neuronal network with a mix of excitatory and inhibitory neurons and sufficient connectivity creates similar coarse-conjunctive encoding of input sequences.
ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation
Authors: Walenta Lena , Fleck David , Fröhlich Thomas , von Eysmondt Hendrik , Arnold Georg J. , Spehr Jennifer , Schwarzer J. Ullrich , Köhn Frank-Michael , Spehr Marc , Mayerhofer Artur 
Published: January 2018

AbstractPeritubular myoid cells, which form the walls of seminiferous tubules in the testis, are functionally unexplored. While they transport sperm and contribute to the spermatogonial stem cell niche, specifically their emerging role in the immune surveillance of the testis and in male infertility remains to be studied. Recently, cytokine production and activation of Toll-like receptors (TLRs) were uncovered in cultured peritubular cells. We now show that human peritubular cells express purinergic receptors P2RX4 and P2RX7, which are functionally linked to TLRs, with P2RX4 being the prevalent ATP-gated ion channel. Subsequent ATP treatment of cultured peritubular cells resulted in up-regulated (pro-)inflammatory cytokine expression and secretion, while characteristic peritubular proteins, that is smooth muscle cell markers and extracellular matrix molecules, decreased. These findings indicate that extracellular ATP may act as danger molecule on peritubular cells, able to promote inflammatory responses in the testicular environment.
Seizure development in the acute intrahippocampal epileptic focus
Authors: Li Lin , Kriukova Kseniia , Engel Jerome , Bragin Anatol 
Published: January 2018

AbstractCurrently, an epileptic seizure is considered to involve a temporary network that exists for a finite period of time. Formation of this network evolves through spread of epileptiform activity from a seizure onset zone (SOZ). Propagation of seizures evoked by kainic acid injection in hippocampus to different brain areas was analyzed at macro- and micro-intervals. The mean latency of seizure occurrence in different brain areas varied between 0.5 sec and 85 sec (mean 14.9 ± 14.5 (SD)), and it increased after each consecutive seizure in areas located contralateral to the area of injection, but not in the ipsilateral sites. We have shown that only 41% of epileptic individual events in target brain areas were driven by epileptic events generated in the SOZ once the seizure began. Fifty-nine percent of epileptiform events in target areas occurred one millisecond before or after events in the SOZ. These data illustrate that during seizure maintenance, only some individual epileptiform events in areas outside of SOZ could be consistently triggered by the SOZ; and the majority must be triggered by a driver located outside the SOZ or brain areas involved in ictal activity could be coupled to each other via an unknown mechanism such as stochastic resonance.
Sporadic nesting reveals long distance colonisation in the philopatric loggerhead sea turtle (Caretta caretta)
Authors: Carreras Carlos , Pascual Marta , Tomás Jesús , Marco Adolfo , Hochscheid Sandra , Castillo Juan José , Gozalbes Patricia , Parga Mariluz , Piovano Susanna , Cardona Luis 
Published: January 2018

AbstractThe colonisation of new suitable habitats is crucial for species survival at evolutionary scale under changing environmental conditions. However, colonisation potential may be limited by philopatry that facilitates exploiting successful habitats across generations. We examine the mechanisms of long distance dispersal of the philopatric loggerhead sea turtle (Caretta caretta) by analysing 40 sporadic nesting events in the western Mediterranean. The analysis of a fragment of the mitochondrial DNA and 7 microsatellites of 121 samples from 18 of these nesting events revealed that these nests were colonising events associated with juveniles from distant populations feeding in nearby foraging grounds. Considering the temperature-dependent sex determination of the species, we simulated the effect of the incubation temperature and propagule pressure on a potential colonisation scenario. Our results indicated that colonisation will succeed if warm temperature conditions, already existing in some of the beaches in the area, extend to the whole western Mediterranean. We hypothesize that the sporadic nesting events in developmental foraging grounds may be a mechanism to overcome philopatry limitations thus increasing the dispersal capabilities of the species and the adaptability to changing environments. Sporadic nesting in the western Mediterranean can be viewed as potential new populations in a scenario of rising temperatures.
Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon
Authors: Ni Thomas K. , Elman Jessica S. , Jin Dexter X. , Gupta Piyush B. , Kuperwasser Charlotte 
Published: January 2018

AbstractIn cancer, tumor suppressor genes (TSGs) are frequently truncated, causing their encoded products to be non-functional or dominant-negative. We previously showed that premature polyadenylation (pPA) of MAGI3 truncates the gene, switching its functional role from a TSG to a dominant-negative oncogene. Here we report that MAGI3 undergoes pPA at the intron immediately downstream of its large internal exon, which is normally highly modified by N6-methyladenosine (m6A). In breast cancer cells that upregulate MAGI3
pPA
, m6A levels in the large internal exon of MAGI3 are significantly reduced compared to cells that do not express MAGI3
pPA
. We further find that MAGI3
pPA
transcripts are significantly depleted of m6A modifications, in contrast to highly m6A-modified full-length MAGI3 mRNA. Finally, we analyze public expression data and find that other TSGs, including LATS1 and BRCA1, also undergo intronic pPA following large internal exons, and that m6A levels in these exons are reduced in pPA-activated breast cancer cells relative to untransformed mammary cells. Our study suggests that m6A may play a role in regulating intronic pPA of MAGI3 and possibly other TSGs, warranting further investigation.