bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-dose hydrocortisone replacement is associated with improved arterial stiffness index and blood pressure dynamics in severely adrenocorticotrophin-deficient hypopituitary male patients
Authors: Behan Lucy-Ann , Carmody David , Rogers Bairbre , Hannon Mark J , Davenport Colin , Tormey William , Smith Diarmuid , Thompson Christopher J , Stanton Alice , Agha Amar 
Published: March 2016

ObjectiveIncreased cardiovascular and cerebrovascular morbidity and mortality in hypopituitary subjects may be linked to inappropriate glucocorticoid exposure; however, the pathophysiology remains unclear. We aimed to examine the effect of three commonly prescribed hydrocortisone (HC) regimens on vascular risk factors.DesignAn open crossover study randomising ten hypopituitary men with severe adrenocorticotrophic hormone deficiency to three HC dose regimens: dose A (20mgmaneand 10mgtarde), dose B (10mgmaneand 10mgtarde) and dose C (10mgmaneand 5mgtarde).MethodsFollowing 6 weeks on each regimen, participants underwent 24-h serum cortisol sampling, 24-h ambulatory blood pressure (BP) measurements, calculation of the Ambulatory Arterial Stiffness Index (AASI), oral glucose tolerance testing and fasting serum osteoprotegerin (OPG) sampling.ResultsThere were no differences in 24-h BP between dose regimens and controls; however, low-dose HC replacement (dose C) was associated with the lowest AASI, indicating a less stiff arterial tree (P<0.05) compared with the other dose regimens. Loss of the physiologic nocturnal BP dip was more common in higher HC replacement regimens, although only significant for dose B compared with dose C (P=0.03). Twenty per cent of patients had abnormal glucose tolerance, but this was unrelated to dose regimen. OPG correlated strongly with 24-h BP in those on dose A only (r=0.65,P=0.04).ConclusionCurrently prescribed HC replacement doses do not result in significant differences in absolute BP levels or improvements in insulin sensitivity. However, lower HC doses may result in lower arterial stiffness and a more physiological nocturnal BP dip. Long-term studies are required to confirm these findings and evaluate their impact on vascular morbidity in this patient group.
Psychometric properties of the Internet Addiction Test in Turkish
Authors: Kaya Fatih , Delen Erhan , Young Kimberly S. 
Published: March 2016

Background and aims
In this study, the Internet Addiction Test (IAT) was adapted to Turkish language, which was originally developed by Young (1998) in English to measure the presence and severity of the Internet dependency. The main purpose was to ensure that the psychometric features and the factor structure of the test were suitable for Turkish university students.

Method
The study was conducted in two sequent phases. Participants were 990 undergraduate students from several public universities in Turkey.

Results
In the first phase, an exploratory factor analysis (EFA) was applied to figure out the factor structure of the Turkish version of the IAT. The EFA revealed four factors, which explained 46.02% of the total variance. In the following phase, a confirmatory factor analysis (CFA) was conducted with a different sample, to verify the factor structure that was found in the initial EFA. The CFA resulted four-factor model was satisfactory for the Turkish version of the IAT. These four factors were named as Mood, Relationship, Responsibilities, and Duration.

Conclusions
Based on the findings, the administration of Turkish version of the IAT provided acceptable results on undergraduate students.
Under the influence of Facebook? Excess use of social networking sites and drinking motives, consequences, and attitudes in college students
Authors: Hormes Julia M. 
Published: March 2016

Background and aims
Excessive use of social networking sites (SNS) has recently been conceptualized as a behavioral addiction (i.e., “disordered SNS use”) using key criteria for the diagnosis of substance dependence and shown to be associated with a variety of impairments in psychosocial functioning, including an increased risk of problem drinking. This study sought to characterize associations between “disordered SNS use” and attitudes towards alcohol, drinking motives, and adverse consequences resulting from alcohol use in young adults.

Methods
Undergraduate students (n = 537, 64.0% female, mean age = 19.63 years, SD = 4.24) reported on their use of SNSs and completed the Alcohol Use Disorders Identification Test, Temptation and Restraint Inventory, Approach and Avoidance of Alcohol and Drinking Motives Questionnaires, and Drinker Inventory of Consequences.

Results
Respondents meeting previously established criteria for “disordered SNS use” were significantly more likely to use alcohol to cope with negative affect and to conform to perceived social norms, reported significantly more conflicting (i.e., simultaneous positive and negative) attitudes towards alcohol, and had experienced significantly more, and more frequent adverse consequences from drinking in their inter- and intrapersonal, physical, and social functioning, compared to individuals without problems related to SNS use.

Discussion and conclusions
Findings add to an emerging body of literature suggesting a link between excess or maladaptive SNS use and problems related to alcohol in young adults and point to emotion dysregulation and coping motives as potential shared risk factors for substance and behavioral addictions in this demographic.
The impact of precommitment on risk-taking while gambling: A preliminary study
Authors: Brevers Damien , Noel Xavier , Clark Luke , Zyuzin Jekaterina , Justin park Joohwan , Bechara Antoine 
Published: March 2016

Background and aims
Precommitment refers to the ability to prospectively restrict the access to temptations. This study examined whether risk-taking during gambling is decreased when an individual has the opportunity to precommit to his forthcoming bet.

Methods
Sixty individuals participated in a gambling task that consisted of direct choice (simply chose one monetary option among four available ones, ranging from low-risk to high-risk options) or precommitment trials (before choosing an amount, participants had the opportunity to make a binding choice that made high-risk options unavailable).

Results
We found that participants utilized the precommitment option, such that risk-taking was decreased on precommitment trials compared to direct choices. Within the precommitment trials, there was no significant difference in risk-taking following decisions to restrict versus non-restrict.

Discussion
These findings suggest that the opportunity to precommit may be sufficient to reduce the attractiveness of risk.

Conclusions
Present results might be exploited to create interventions aiming at enhancing one’s ability to anticipate self-control failures while gambling.
The development of the Problematic Series WatchingScale (PSWS)
Authors: Orosz Gábor , Bőthe Beáta , Tóth-Király István 
Published: March 2016

Background and aims
The goal of the present study was to create a short ProblematicSeries Watching Scale (PSWS).

Methods
On the basis of the six components model of Griffiths (2005), six items were identifiedcovering all components of problematic series watching. Confirmatoryfactor analyses were carried out on two independent samples (N1 = 366, N2 = 752).

Results
The PSWS has appropriate factor structure and reliability. Theamount of free time was not, but the series watching time was associatedwith PSWS scores. Women had higher scores than men.

Discussion
Before PSWS, no prior scale has been created to measure problematicseries watching. Further research is needed to properly assess itsvalidity and reliability; and for examining whether extensive serieswatching can lead to health-related and psychosocial problems.

Conclusions
In the increasingly digitalized world there are many motivationalforces which encourage people watching online series. In the lightof these changes, research on problematic series watching will beprogressively relevant.
From the mouths of social media users: A focus group study exploring the social casino gaming–online gambling link
Authors: Kim Hyoun S. , Wohl Michael J. A. , Gupta Rina , Derevensky Jeffrey 
Published: March 2016

Background and aims
The potential link between social casino gaming and online gambling has raised considerable concerns among clinicians, researchers and policy makers. Unfortunately, however, there is a paucity of research examining this potential link, especially among young adults. This represents a significant gap given young adults are frequently exposed to and are players of social casino games.

Methods
To better understand the potential link between social casino games and online gambling, we conducted three focus groups (N = 30) at two large Canadian Universities with college students who were avid social media users (who are regularly exposed to social casino games).

Results
Many participants spontaneously mentioned that social casino games were a great opportunity to build gambling skills before playing for real money. Importantly, some participants expressed a belief that there is a direct progression from social casino gaming to online gambling. Conversely, others believed the transition to online gambling depended on a person’s personality, rather than mere exposure to social casino games. While many young adults in our focus groups felt immune to the effects of social casino games, there was a general consensus that social casino games may facilitate the transition to online gambling among younger teenagers (i.e., 12–14 yr olds), due to the ease of accessibility and early exposure.

Discussion
The results of the present research point to the need for more study on the effects of social casino gambling as well as a discussion concerning regulation of social casino games in order to minimize their potential risks.
A longitudinal study of factors explaining attitude change towards gambling among adolescents
Authors: Pallesen Ståle , Hanss Daniel , Molde Helge , Griffiths Mark D. , Mentzoni Rune Aune 
Published: March 2016

Background and aims
No previous study has investigated changes in attitudes toward gambling from under legal gambling age to legal gambling age. The aim of the present study was therefore to investigate attitudinal changes during this transition and to identify predictors of corresponding attitude change.

Methods
In all 1239 adolescents from a national representative sample participated in two survey waves (Wave 1; 17.5 years; Wave 2; 18.5 years).

Results
From Wave 1 to Wave 2 the sample became more acceptant toward gambling. A regression analysis showed that when controlling for attitudes toward gambling at Wave 1 males developed more acceptant attitudes than females. Neuroticism was inversely related to development of acceptant attitudes toward gambling from Wave 1 to Wave 2, whereas approval of gambling by close others at Wave 1 was positively associated with development of more acceptant attitudes. Continuous or increased participation in gambling was related to development of more acceptant attitudes from Wave 1 to Wave 2.

Conclusions
Attitudes toward gambling became more acceptant when reaching legal gambling age. Male gender, approval of gambling by close others and gambling participation predicted development of positive attitudes toward gambling whereas neuroticism was inversely related to development of positive attitudes toward gambling over time.
Clinical Trials of Antiangiogenesis Therapy in Recurrent/Persistent and Metastatic Cervical Cancer
Authors: Alldredge Jill K. , Tewari Krishnansu S. 
Published: March 2016

Abstract

Background.
Treatment options for women with metastatic, persistent, or recurrent cervical cancer are limited and thus the disease portends a poor prognosis. It is critical to understand the pathophysiology of cervical cancer to better delineate therapeutic targets. The development of antiangiogenic therapies and their subsequent analysis in rigorous therapeutic trials have redefined current management strategies and is an exciting area of current exploration.

Results.
Translational trials have furthered the understanding of molecular determinants of angiogenesis. Phase II trials have shown promising trends with developing antiangiogenic therapies. A practice-changing phase III trial has recently been published. Given the potential benefits and different toxicity spectrum compared with standard cytotoxic chemotherapy, antiangiogenic options are under active investigation for this vulnerable patient population. Emerging data are promising for other antiangiogenic-directed therapeutics, as well as cervical cancer molecular biomarkers to guide diagnosis and treatment.

Conclusion.
Antiangiogenic therapies have evolved during the past 20 years and remain an exciting area of current exploration.
Risk of Congestive Heart Failure in Early Breast Cancer Patients Undergoing Adjuvant Treatment With Trastuzumab: A Meta-Analysis
Authors: Long Hui-Dong , Lin Yun-En , Zhang Juan-Juan , Zhong Wen-Zhao , Zheng Rui-Nian 
Published: March 2016

Abstract

Background.
The use of trastuzumab has proven to be a successful strategy in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer; however, it is associated with an increased risk of cardiac dysfunction. We performed an up-to-date, comprehensive meta-analysis to clarify the risk of congestive heart failure (CHF) in patients with early breast cancer receiving different durations of adjuvant trastuzumab with the longest-term follow-up.

Methods.
Eligible studies included randomized control trials of HER2-positive early breast cancer patients with or without trastuzumab in adjuvant chemotherapy. Adequate reporting of CHF data were required for inclusion. Statistical analyses were conducted to calculate the overall incidence, relative risk (RR), and 95% confidence interval (CI) by use of a fixed-effects model.

Results.
Six randomized control trials including 18,111 patients were identified. The overall incidence of high-grade CHF in patients treated with trastuzumab versus placebo was 1.44% (95% CI, 0.79%–2.64%) and the RR was 3.19 (95% CI, 2.03–5.02; p &lt; .00001). In subgroup analysis, the difference in CHF incidence failed to achieve significance. The RR for 8 mg/kg trastuzumab (high dose) was greater than that for 4 mg/kg (low dose) (RR, 6.79, 95% CI, 2.03–22.72, p = .0001; versus RR, 2.64; 95% CI, 1.61–4.32; p = .002). Additionally, higher RRs were observed for patients receiving trastuzumab for 1 year (RR, 3.29; 95% CI, 2.07–5.25) and 2 years (RR, 9.54; 95%CI, 2.19–41.43), but not 9 weeks (RR, 0.50; 95% CI, 0.05–5.49) compared with control groups. No evidence of publication bias was observed.

Conclusion.
Adjuvant trastuzumab therapy was strongly associated with an increased risk of significant CHF in patients with early breast cancer, particularly in 2-year use.
Age-related alterations in arginase-NO-synthase system in patients with coronary heart disease associated with hypertension
Authors: Besedina Anna 
Published: March 2016

WstępChoroba wieńcowa jest najpowszechniejszą z chorób serca występujących na terenie Europy. Celem pracy było zbadanie intensywności metabolizmu L-argininy dwoma alternatywnymi sposobami (utleniającym przez NOS i nieutleniającym poprzez arginazę) w osoczu krwi pacjentów cierpiących na chorobę wieńcową (ChW) serca, współistniejącą z nadciśnieniem tętniczym (NT), w grupie pacjentów w różnym wieku.Materiał i metodyDo badania włączono 50 pacjentów z izolowaną postacią ChW i 42 z ChW współistniejącą z NT. Aktywność NOS została wyznaczona przez anion azotynowy utworzony w reakcji. Aktywność arginazy sprawdzono przez formowanie mocznika.WynikiPacjenci w średnim wieku, z izolowaną postacią ChW wykazywali 2,2 razy wyższą całkowitą aktywność NOS w porównaniu ze zdrowymi badanymi w tej samej grupie wiekowej. W przypadku pacjentów z ChW współistniejącą z NT całkowita aktywność NOS była znacząco (2,3 razy) zwiększona w obu grupach wiekowych (w średnim oraz starszym wieku) w porównaniu z osobami zdrowymi w tym samym wieku. U pacjentów z izolowaną postacią ChW aktywność arginazy była 1,5 razy podwyższona u osób w średnim wieku oraz 1,7 razy u starszych niż u osób zdrowych. W wieku średnim i starszym pacjenci ze współistniejącą postacią ChW wraz z NT wykazywali statystycznie znacznie podwyższoną aktywność arginazy – odpowiednio 1,7 oraz 1,8 razy większą niż u zdrowych w tym samym wieku.WnioskiWykazano, że w grupie pacjentów z izolowaną postacią ChW oraz w przypadku współistnienia ChW i NT aktywność NO-syntazy i arginazy jest wyższa niż u osób zdrowych. Zwiększona aktywność NO-syntazy i arginazy jest bardziej znacząca u pacjentów starszych.
Infección urinaria en pacientes con cateterismo vesical con sistema de drenaje cerrado, utilizando un frasco colector recambiable.
Authors: Valdez Rosario , Miyahira Arakaki Juan 
Published: March 2016

Con el objetivo de determinar la incidencia de ITU asociado a cateterismo vesical con sistema de drenaje cerrado utilizando un frasco recambiable, fueron evaluados 20 pacientes no críticos, cateterizados por 5 días. Se encontró una incidencia de bacteriuria asociada a cateterismo vesical de 5%, mientras que la contaminación del frasco de drenaje se documento en el 10% de los pacientes. Tanto la bacteriuría, como la contaminación del frasco colector ocurrieron a las 96 horas de cateterismo vesical. Se concluye que el sistema de drenaje cerrado utilizando un frasco recambiable es adecuado para pacientes que requieran catéter vesical por corto tiempo, debido a su baja incidencia de bacteriuria y su bajo costo.
Larva migrans cutánea en Lima. Reporte de 3 casos.
Authors: Legua Pedro , Guerra Jorge , Bussalleu Alejandro 
Published: March 2016

Larva migrans cutánea o “erupción reptante” es una erupción cutánea causada por la migración de la larva de un nemátodo en forma errática en la piel. Ocurre usualmente como resultado de la exposición de la piel a las larvas filariformes infectantes de uncinarias propias de felinos y cánidos, que están presentes en suelos húmedos y arenosos en los que estos animales defecan (playas, jardines, parques, etc.).La larvainfectante no puede completar su ciclo vital en el hospedero humano y entonces persiste en la piel causando este cuadro
Histoplasmosis diseminada en SIDA. Presentación de un caso y revisión de la literatura.
Authors: Bustamante Beatriz , Seas Carlos , Sanchez Jorge , Gottuzo Eduardo 
Published: March 2016

Histoplasmosis diseminada es una condición poco frecuente, presentándose en menos del 10% de los casos sintomáticos por esta enfermedad. Se reconoce a niños, ancianos inmunosuprimidos por depresión de la inmunidad celular, recipientes de transplante renal o de médula ósea y a pacientes en tratamiento esteroideo prolongado,como individuos en riesgo.
Septicemia por Aeromona hidrophila
Authors: Yi A. , Sack B. , Maurtua D , Guerrero C 
Published: March 2016

Las aeromonas son bacilos gram negativos móviles que fermentan los carbohidratos;son oxidasa positivo y crecen bien en los medios de cultivo para aislar enterobacteriaceaes. Actualmente las aeromonas son señaladas como agente etiológico de una variedad de procesos infecciosos que amenazan la vida de los pacientes.
Modelo de actuación para la mejora de la eficiencia energética en la Rehabilitación Integral de un palacete protegido para oficinas de la Administración en Madrid. Geotermia y estructuras termoactivas
Authors: De Pereda Fernández Luis 
Published: March 2016

ResumenEn este trabajo se realiza un estudio sobre el fondo de la cuestión de la técnica aplicada a la mejora de la eficiencia. Con este punto de partida podemos profundizar en las claves en el uso de los recursos para la eficiencia energética y concretarlas en un modelo de actuación que ilustra una aproximación sistémica al campo del aprovechamiento de la energía, y que reintegra a la edificación su valor intrínseco como medio eficiente de gestión de la energía y su transformación. AbstractThis paper presents a study on the substance of the matter of the technique applied to improving efficiency is performed. With this starting point we can deepen the keys in the use of resources for energy efficiency and achieve them in a role model illustrating a systemic approach to the field of energy efficiency, and reintegrated into the building its intrinsic value as efficient means of energy management and processing.
Correlation of the ratio of caudal vena cava diameter and aorta diameter with systolic pressure variation in anesthetized dogs
Authors: Meneghini Caterina , Rabozzi Roberto , Franci Paolo 
Published: March 2016

Abstract
OBJECTIVE To evaluate the correlation coefficient of the ratio between diameter of the caudal vena cava (CVC) and diameter of the aorta (Ao) in dogs as determined ultrasonographically with systolic pressure variation (SPV).
ANIMALS 14 client-owned dogs (9 females and 5 males; mean ± SD age, 73 ± 40 months; mean body weight, 22 ± 7 kg) that underwent anesthesia for repair of skin wounds.
PROCEDURES Anesthesia was induced. Controlled mechanical ventilation with a peak inspiratory pressure of 8 cm H2O was immediately started, and SPV was measured. During a brief period of suspension of ventilation, CVC-to-Ao ratio was measured on a transverse right-lateral intercostal ultrasonographic image obtained at the level of the porta hepatis. When the SPV was ≥ 4 mm Hg, at least 1 bolus (3 to 4 mL/kg) of Hartmann solution was administered IV during a 1-minute period. Bolus administration was stopped and the CVC-to-Ao ratio measured when SPV was < 4 mm Hg. Correlation coefficient analysis was performed.
RESULTS 28 measurements were obtained. The correlation coefficient was 0.86 (95% confidence interval, 0.72 to 0.93). Mean ± SD SPV and CVC-to-Ao ratio before bolus administration were 7 ± 2 mm Hg and 0.52 ± 0.16, respectively. Mean ± SD SPV and CVC-to-Ao ratio after bolus administration were 2 ± 0.6 mm Hg and 0.91 ± 0.13, respectively.
CONCLUSIONS AND CLINICAL RELEVANCE In this study, the CVC-to-Ao ratio was a feasible, noninvasive ultrasonographically determined value that correlated well with SPV. (Am J Vet Res 2016;77:137–143)
Adherence of methicillin-resistant Staphylococcus pseudintermedius to suture materials commonly used in small animal surgery
Authors: Morrison Shauna , Singh Ameet , Rousseau Joyce , Weese J. Scott 
Published: March 2016

Abstract
OBJECTIVE To evaluate adherence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) to 5 suture materials commonly used in small animal surgery.
SAMPLE 10 epidemiologically unrelated MRSP isolates (obtained from dogs with clinical infections) that had strong biofilm-forming ability and 5 types of suture.
PROCEDURES The 5 types of suture evaluated were monofilament polyglecaprone 25, monofilament polydioxanone, triclosan-coated (TC)–monofilament polydioxanone, braided polyglactin 910, and barbed monofilament polydioxanone. Suture segments were incubated in standard suspensions of MRSP for 2 minutes. Segments were then placed in tryptone soy broth and incubated overnight. After incubation, segments were rinsed with PBS solution and sonicated to dislodge adherent bacteria. Resulting suspensions were used to create serial dilutions that were plated, incubated overnight, and counted the following day. Bacterial adherence to 1 segment of each suture type was assessed by use of scanning electron microscopy.
RESULTS There was significantly less adherence of MSRP to TC–monofilament polydioxanone than to polyglecaprone 25, polyglactin 910, barbed monofilament polydioxanone, and monofilament polydioxanone. There was significantly less adherence of MSRP to polyglecaprone than to polyglactin 910.
CONCLUSIONS AND CLINICAL RELEVANCE Barbed suture had a bacterial adherence profile comparable to that for monofilament suture. Adherence of MRSP was greatest for braided polyglactin 910. Use of TC–monofilament polydioxanone can be considered for patients that are at high risk of developing surgical site infections and for which a surgeon chooses a multifilament suture. (Am J Vet Res 2016;77:194–198)