bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ex vivo experimental study on the Thulium laser system: new horizons for interventional endoscopy (with videos)
Authors: Tontini Gian , Neumann Helmut , Rimondi Alessandro , Vavassori Sara , Bruni Barbara , Cattignoli Gregorio , Zhou Ping-Hong , Pastorelli Luca , Vecchi Maurizio 
Published: July 2017

Abstract
Background and study aims The Thulium laser system (TLS) is an emerging interventional tool adopted in many surgical specialties. Its 2.0-μm wavelength allows precise coagulation (0.2 – 0.4 mm in depth) and cutting, limiting the possibilities of collateral injuries. We tested the impact of the TLS for gastric endoscopic submucosal dissection (ESD) and per oral endoscopic myotomy (POEM) ex vivo in pigs.
Materials and methods Ex vivo porcine stomach and esophagus models underwent 2 POEMs, and 3 ESDs (mean diameter 3.5 cm) with TLS using a 272-µm and a 365-µm thick optical fibers. Both continuous and pulsed laser emission were evaluated. Subsequent histopathological analysis was performed by an expert GI pathologist on the whole porcine models.
Results Complete POEMs and gastric ESDs were successfully performed in all cases in 30 to 70 and 15 to 20 minutes. Both optical fibers were equally effective and precise. The best power output for mucosal incision was 25 to 30 W during ESD and 25 W for POEM using continuous laser emission. During submucosal dissection and tunneling the favorite power output was 20 W and 15 to 20 W, respectively, operating in continuous mode. No transmural perforation occurred throughout the operations and histopathology confirmed the absence of accidental muscular layer damage.
Conclusions The TLS stands out as a precise and manageable instrument in ex vivo models. This technique appears to be a promising tool for advanced interventional endoscopy.
A novel “hitch-and-ride” deep biliary cannulation method during rendezvous endoscopic ultrasound-guided ERCP technique
Authors: Nakai Yousuke , Isayama Hiroyuki , Matsubara Saburo , Kogure Hirofumi , Mizuno Suguru , Hamada Tsuyoshi , Takahara Naminatsu , Nakamura Tomoka , Sato Tatsuya , Takeda Tsuyoshi , Hakuta Ryunosuke , Ishigaki Kazunaga , Saito Kei , Tada Minoru , Koike Kazuhiko 
Published: July 2017

Abstract
Background and study aim Endoscopic ultrasound-guided rendezvous (EUS-RV) is increasingly reported as a treatment option after failed endoscopic retrograde cholangiopancreatography. We developed a novel “hitch-and-ride” catheter for biliary cannulation to reduce the risk of guidewire loss during EUS-RV.
Patients and methods We retrospectively evaluated safety and technical success of EUS-RV between June 2011 and May 2016. Biliary cannulation during EUS-RV using three methods – over-the-wire, along-the-wire, and hitch-and-ride – were compared.
Results A total of 30 EUS-RVs were attempted and the technical success rate was 93.3 %, with two failures (one bile duct puncture and one guidewire insertion). After 28 cases of successful guidewire passage, cannulation was attempted by the over-the-wire (n = 13), along-the-wire (n = 4) or hitch-and-ride (n = 11) method. Only the hitch-and-ride method achieved biliary cannulation without guidewire loss or conversion to the other methods. Time to cannulation was shorter with the hitch-and-ride method (4 minutes) than with over-the-wire and along-the-wire methods (9 and 13 minutes, respectively). The adverse event rate of EUS-RV was 23.3 %.
Conclusion A novel hitch-and-ride catheter was feasible for biliary cannulation after EUS-RV.
Variable clitic placement in US Spanish
Authors: Limerick Philip P. 
Published: July 2017

Abstract
This study examines clitic placement (CP) among US Spanish-speakers using data from two corpora: Corpus del Español en el Sur de Arizona (Carvalho, 2012–) and a corpus of interviews conducted in Roswell, Georgia (Wilson, 2013). Clitics were analyzed and coded for linguistic and social variables (e.g. specific construction, age of arrival). Results indicate an overall proclisis rate of 67%, which is similar to the rate reported for speakers in Mexico City (e.g. Davies, 1995). A subsequent multivariate analysis reveals that CP is significantly influenced by the specific construction used, the non-finite verb form, and the speakers’ age of arrival. This analysis lends support to the argument for the impermeability of CP to contact-induced change in Spanish (Silva-Corvalán & Gutiérrez, 1995).
Are Argentines a-blind?
Authors: Hoff Mark R. 
Published: July 2017

Abstract
I examine syntactic and discursive factors conditioning the variable a-marking of inanimate DOs in Argentine Spanish, using an online questionnaire which includes 16 contextualized discourse items recorded by native Argentines. Argentine respondents (N = 140) evaluated acceptability of the items using a 5-point Likert scale. Linguistic predictors analyzed include: definiteness, mono- vs. ditransitive constructions, and topicality, operationalized in terms of pre-/post-verbal position and referential distance. Mixed-effects analyses in R showed that although participants assigned significantly higher ratings to normative unmarked inanimate DOs than to a-marked ones, a-marking was still widely accepted, with definite DOs, pre-verbal position, and monotransitivity as significant predictors of acceptance. Furthermore, in 10/16 cases, participant ratings showed no significant difference between marked and unmarked DOs, demonstrating that participants are, to an extent, “a-blind” or uninfluenced by marking.
Acquisition of articulatory control or language-specific coarticulatory patterns?
Authors: Solon Megan 
Published: July 2017

Abstract
The present study examines the acquisition of coarticulatory patterns in Spanish as a second language (L2). Through an acoustic analysis of the production of /l/ preceded by a front vowel and by a back vowel by a large cross-sectional sample of English-speaking learners of Spanish (n = 85) and a comparison of L2 Spanish patterns to those in L1 Spanish (n = 20 speakers) and in L1 English, evidence is provided that, similar to the acquisition of other phonetic detail, acquisition of coarticulation proceeds from more L1-like patterns in early stages of learning toward more targetlike coarticulatory patterns in later stages. Additionally, acquisition of coarticulation does not seem to be tied to overall segmental acquisition.
Voice onset time and the child foreign language learner of Spanish
Authors: Menke Mandy R. 
Published: July 2017

Abstract
Stop consonants are one of the most investigated sound classes in second language speech production studies. Robust age of acquisition effects are documented in the literature base; however, the advantage of early learners has been primarily documented in second language, not foreign language, contexts. In order to further tease apart the variables of age and context, this paper compares the VOT values of /p, t, k/ of a cross-sectional sample of child, foreign language learners of Spanish with those of Spanish-English bilinguals. Learner productions did not differ from those of native speaking peers, yet there was a significant interaction of first language and grade level, suggesting that age of acquisition alone is insufficient to explain outcomes. Quantity of input, in both the first and second/foreign language, is explored as a possible explanation.
Extra-syntactic factors in the that-trace effect
Authors: Heil Jeanne , Ebert Shane 
Published: July 2017

Abstract
Using predictions from the Interface Hypothesis and the grammar of Spanish-English bilinguals, we test whether non-syntactic factors play a role in the that-trace effect. Though generally analyzed syntactically, some work on that-trace supports a syntax-prosody account (Kandybowicz, 2006). The Interface Hypothesis predicts that bilinguals will have difficulty with interface phenomena but not narrow syntax, such that testing bilinguals’ knowledge of that-trace provides a unique testing ground for comparing the two approaches. We demonstrate that bilinguals have the syntactic underpinnings necessary for both syntactic and syntax-prosody accounts of that-trace; however, they differ from the monolinguals with regard to that-trace, extending the phenomenon’s restriction on extraction to a new context, supporting a syntax-prosody account of that-trace.
Tracing facework over time using semi-automated methods
Authors: Archer Dawn , Malory Bethan 
Published: July 2017

AbstractImpolite behaviour tends to attract more evaluative comment than other facework, making it easier to investigate synchronically and diachronically. A reliance on metapragmatic commentary is not optimum for UK parliamentary studies, however, as MPs cannot use “insulting or rude language” that breaks the chamber’s “rules of politeness” (www.parliament.uk). The work reported here thus offers three innovative methods of tracing MPs’ facework as they negotiated the “unparliamentary language” prohibition, and the results gleaned when the methods were applied to Hansard records (1812–2004). Method 1 prioritises portmanteau tags made up of USAS semtags. Method 2 prioritises themes derived from the HTOED. Method 3 draws on ‘meaning constellations’ (i.e. simultaneous searches of multiple tags). The UK parliamentary website highlights the “considerable ingenuity” displayed by MPs in order to circumvent their unparliamentary language prohibition. All methods have found examples of such ingenuity, many of which are characterized by multiple facework intentions (Archer 2015).
The importance of,it is important thatorimportantly?
Authors: Larsson Tove 
Published: July 2017

AbstractThe ability to successfully position oneself in relation to one’s claims through the use of stance markers is of central importance for academic writers. This study, which uses data from one expert corpus (LOCRA) and three learner corpora (ALEC, VESPA and BATMAT), investigates the use of morphologically related stance markers that occur in different syntactic constructions (such aspossibly, the possibility ofandit is possible that). In doing so, it examines to what extent lexis, level of expertise in academic writing and L1 transfer influence the distribution of the different realizations of stance under investigation. The results show that all three variables are important predictors. In addition, differences pertaining to information structure are found to influence the distribution of two largely synonymous constructions (disjuncts and the introductoryitpattern). The findings suggest that there are principled explanations for why one construction is used instead of another functionally similar construction.
語音標記性與維漢聲調匹配
Authors: Du Zhaojin , Chen Baoya 
Published: July 2017

抽象
本文以無聲調的維吾爾語和有聲調的漢語的自然接觸作為研究對象，通過田野調查收集維吾爾族人說漢語的第一手材料，以語音標記性差異的視角，觀察、分析維漢自然接觸環境下維吾爾族人學習漢語聲調的具體過程、特點和規律。研究發現，維漢接觸中維吾爾族人以維吾爾語的詞調調型來匹配漢語聲調；隨著維吾爾族人漢化程度的提高，聲調匹配逐步實現由「無序匹配」向「有序匹配」的轉化，這是一個相對緩慢的發展過程，往往要經歷「無聲調意識→有聲調意識→聲調匹配有序化開始→實現聲調有序匹配」等幾個階段；維漢接觸中聲調實現有序匹配需要相當長的時間，是由聲調的標記性高造成的。這一過程可稱為「聲調標記匹配有序化」。
Narratives of sex-segregated professional identities
Authors: McEntee-Atalianis Lisa , Litosseliti Lia 
Published: July 2017

AbstractBuilding on recent investigations of the role of gendered discourses in constructing and maintaining sex-segregated professions this article highlights the significance of small story analysis for the identification of positioning acts which function as rhetorical warrants for career choices and trajectories. It analyses small stories told by Speech and Language Therapists (SLTs) and investigates the tensions expressed in the negotiation and performance of their gendered professional identities. Small stories act as a medium of professional identity construction, rapport-building and as a site of contestation, employed to (re)appraise the social order, particularly with respect to 'women's' and 'men's' work. Gendered discourses are shown to impact not only on the amount of men entering the SLT profession but also the specialisms and progression routes that men and women pursue. The analysis points to the reproductive and regulatory power of gendered discourses on individuals' experience of their gendered subjectivity and professional identity.
“Losing my religion”
Authors: Scharp Kristina M. , Beck Aubrey L. 
Published: July 2017

Abstract
The present study explores how former members of the Church of Jesus Christ of Latter-day Saints, who are often referred to as Mormons, construct their identities. Framed in an interpretive narrative approach, 150 online exit stories of members of the Church of Jesus Christ of Latter-day Saints that voluntarily left the Church were qualitatively analyzed. Findings reveal five prominent identities: (1) the disenfranchised victim, (2) the redeemed spiritualist, (3) the liberated self, (4) the (wo)men of science, and (5) the Mormon in name only. Results suggest that membership in the Church of Jesus Christ of Latter-day Saints is inextricably connected to individual identity. Thus, exiting the Church is much more than leaving an organization. Future implications for research will be discussed.
CrocoBLAST: Running BLAST efficiently in the age of next-generation sequencing
Authors: Tristão Ramos Ravi José , de Azevedo Martins Allan Cézar , da Silva Delgado Gabrielle , Ionescu Crina-Maria , Ürményi Turán Peter , Silva Rosane , Koča Jaroslav 
Published: July 2017

Abstract

Summary
CrocoBLAST is a tool for dramatically speeding up BLAST+ execution on any computer. Alignments that would take days or weeks with NCBI BLAST+ can be run overnight with CrocoBLAST. Additionally, CrocoBLAST provides features critical for NGS data analysis, including: results identical to those of BLAST+; compatibility with any BLAST+ version; real-time information regarding calculation progress and remaining run time; access to partial alignment results; queueing, pausing, and resuming BLAST+ calculations without information loss.

Availability and implementation
CrocoBLAST is freely available online, with ample documentation (webchem.ncbr.muni.cz/Platform/App/CrocoBLAST). No installation or user registration is required. CrocoBLAST is implemented in C, while the graphical user interface is implemented in Java. CrocoBLAST is supported under Linux and Windows, and can be run under Mac OS X in a Linux virtual machine.

Supplementary information
Supplementary data are available at Bioinformatics online.
Using uncertainty to link and rank evidence from biomedical literature for model curation
Authors: Zerva Chrysoula , Batista-Navarro Riza , Day Philip , Ananiadou Sophia 
Published: July 2017

Abstract

Motivation
In recent years, there has been great progress in the field of automated curation of biomedical networks and models, aided by text mining methods that provide evidence from literature. Such methods must not only extract snippets of text that relate to model interactions, but also be able to contextualize the evidence and provide additional confidence scores for the interaction in question. Although various approaches calculating confidence scores have focused primarily on the quality of the extracted information, there has been little work on exploring the textual uncertainty conveyed by the author. Despite textual uncertainty being acknowledged in biomedical text mining as an attribute of text mined interactions (events), it is significantly understudied as a means of providing a confidence measure for interactions in pathways or other biomedical models. In this work, we focus on improving identification of textual uncertainty for events and explore how it can be used as an additional measure of confidence for biomedical models.

Results
We present a novel method for extracting uncertainty from the literature using a hybrid approach that combines rule induction and machine learning. Variations of this hybrid approach are then discussed, alongside their advantages and disadvantages. We use subjective logic theory to combine multiple uncertainty values extracted from different sources for the same interaction. Our approach achieves F-scores of 0.76 and 0.88 based on the BioNLP-ST and Genia-MK corpora, respectively, making considerable improvements over previously published work. Moreover, we evaluate our proposed system on pathways related to two different areas, namely leukemia and melanoma cancer research.

Availability and implementation
The leukemia pathway model used is available in Pathway Studio while the Ras model is available via PathwayCommons. Online demonstration of the uncertainty extraction system is available for research purposes at http://argo.nactem.ac.uk/test. The related code is available on https://github.com/c-zrv/uncertainty_components.git. Details on the above are available in the Supplementary Material.

Supplementary information
Supplementary data are available at Bioinformatics online.
myVCF: a desktop application for high-throughput mutations data management
Authors: Pietrelli Alessandro , Valenti Luca 
Published: July 2017

Abstract

Summary
Next-generation sequencing technologies have become the most powerful tool to discover genetic variants associated with human diseases. Although the dramatic reductions in the costs facilitate the use in the wet-lab and clinics, the huge amount of data generated renders their management by non-expert researchers and physicians extremely difficult. Therefore, there is an urgent need of novel approaches and tools aimed at getting the ‘end-users’ closer to the sequencing data, facilitating the access by non-bioinformaticians, and to speed-up the functional interpretation of genetic variants. We developed myVCF, a standalone, easy-to-use desktop application, which is based on a browser interface and is suitable for Windows, Mac and UNIX systems. myVCF is an efficient platform that is able to manage multiple sequencing projects created from VCF files within the system; stores genetic variants and samples genotypes from an annotated VCF files into a SQLite database; implements a flexible search engine for data exploration, allowing to query for chromosomal region, gene, single variant or dbSNP ID. Besides, myVCF generates a summary statistics report about mutations distribution across samples and across the genome/exome by aggregating the information within the VCF file. In summary, the myVCF platform allows end-users without strong programming and bioinformatics skills to explore, query, visualize and export mutations data in a simple and straightforward way.

Availability and implementation
https://apietrelli.github.io/myVCF/

Supplementary information
Supplementary data are available at Bioinformatics online.
Troubadours in Time: Remembering the Old Occitan Lyric in Catalonia
Authors: Price Emily Kate 
Published: July 2017

Abstract

This article examines the reception of troubadour song in
So fo e.l temps
, a thirteenth-century Occitan narrative by Catalan author Raimon Vidal. While in this work the Limousin troubadours are revered as authorities, their lyrics and the mistaken reception of them are also subject to scrutiny. In this,
So fo e.l temps
resembles Raimon’s earlier
Razos de trobar
, a grammar of the troubadour vernacular. In the
Razos de trobar
, Raimon complains that while the nouns (or substance) of troubadour lyric are good, its verbs (or predication) are faulty. Troubadour lyric therefore needs to be handled with expertise — which his grammar aims to teach to a select few. In
So fo e.l temps
, Catalan nobleman Uc de Mataplana models this connoisseurship, displaying his dialectical and rhetorical skills as he critiques the use made of troubadour lyric by a lovelorn trio in Limousin. He finds fault with the timeless substance of troubadour love doctrine, which does not translate to the context of lived experience, as the dilemma of the Limousin lovers attests. Uc’s surprising resolution of their situation reveals, however, the complexity of a cultural project that seeks to build — and profit from — the prestige of another vernacular culture, and to demonstrate the superiority of a newer, Catalan, one.
Pinning down the mass of Kepler-10c: the importance of sampling and model comparison
Authors: Rajpaul V. , Buchhave L. A. , Aigrain S. 
Published: July 2017

Abstract
Initial radial velocity (RV) characterization of the enigmatic planet Kepler-10c suggested a mass of ∼17 M⊕, which was remarkably high for a planet with radius 2.32 R⊕; further observations and subsequent analysis hinted at a (possibly much) lower mass, but masses derived using RVs from two different spectrographs (HARPS-N and HIRES) were incompatible at a 3σ level. We demonstrate here how such mass discrepancies may readily arise from suboptimal sampling and/or neglecting to model even a single coherent signal (stellar, planetary or otherwise) that may be present in RVs. We then present a plausible resolution of the mass discrepancy, and ultimately characterize Kepler-10c as having mass $7.37_{-1.19}^{+1.32}$ M⊕, and mean density $3.14^{+0.63}_{-0.55}$ g cm−3.
Precise surface gravities of δ Scuti stars from asteroseismology
Authors: García Hernández A. , Suárez J. C. , Moya A. , Monteiro M. J. P. F. G. , Guo Z. , Reese D. R. , Pascual-Granado J. , Barceló Forteza S. , Martín-Ruiz S. , Garrido R. , Nieto J. 
Published: July 2017

Abstract
The work reported here demonstrates that it is possible to accurately determine surface gravities of δ Scuti (δ Sct) stars using the frequency content from high-precision photometry and a measurement of the parallax. Using a sample of 10 eclipsing binary systems with a δ Sct component and the unique δ Sct star discovered with a transiting planet, WASP-33, we were able to refine the Δν–$\bar{\rho }$ relation. Using this relation and parallaxes, we obtained independent values for the masses and radii, allowing us to calculate the surface gravities without any constraints from spectroscopic or binary analysis. A remarkably good agreement was found between our results and those published, extracted from the analysis of the radial velocities and light curves of the systems. This reinforces the potential of Δν as a valuable observable for δ Sct stars and settles the degeneracy problem for the log g determination through spectroscopy.
Influence of Relative Residence Time on Side-Wall Aneurysm Inception
Authors: Riccardello Gerald J , Shastri Darshan N , Changa Abhinav R , Thomas Kiran G , Roman Max , Prestigiacomo Charles J , Gandhi Chirag D 
Published: July 2017

Abstract

BACKGROUND
Relative residence time (RRT) is a marker of disturbed blood flow, marked by low magnitude and high oscillatory wall shear stress (WSS). The relation between solute residence time in proximity to the vascular endothelium and the atherosclerotic process is well appreciated in the literature.

OBJECTIVE
To assess the influence of RRT on side-wall aneurysm inception to better understand the role of atherosclerosis in aneurysm formation.

METHODS
Fourteen side-wall internal carotid artery aneurysms from the Aneurisk repository which met criteria for parent vessel reconstruction were reconstructed with Vascular Modeling Toolkit. Computational fluid dynamics analysis was carried out in Fluent. RRT was calculated in MATLAB (The MathWorks Inc, Natick, Massachusetts). We analyzed the results for correlations, defined as presence or absence of local elevations in RRT in specific regions of vasculature.

RESULTS
RRT was concluded to be negatively correlated with aneurysm inception in this study of side-wall internal carotid artery aneurysms, with 12/14 cases yielding the absence of local RRT elevations within or in close proximity of the removed ostium. Subsequent analysis of WSS showed that 11 of 14 aneurysms were formed in an atheroprotective environment, with only 1 of 14 formed in an atherogenic environment. Two models were found to be of indeterminate environment.

CONCLUSION
Atherogenesis and atherosclerosis have long been thought to be a major inciting factor responsible for the formation of aneurysms in the cerebral vasculature. We propose that inception of side-wall aneurysms occurs in hemodynamic environments that promote an atheroprotective endothelial phenotype and that the atheroprotective phenotype is therefore aneurysmogenic.