bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cognitive features of idiopathic and DYT1 dystonia
Authors: Jahanshahi Marjan , Torkamani Mariam 
Published: June 2017

ABSTRACTDystonia is a common movement disorder. In this paper, we review the literature on cognitive function in idiopathic and DYT1 dystonia. In idiopathic or DYT1 dystonia, cognition is largely intact with only isolated executive dysfunction. Dystonia patients also have increased temporal and spatial discrimination thresholds, considered endophenotypes of the disorder because deficits are also shown by unaffected relatives and nonmanifesting carriers of the DYT1 mutation. Anticholinergic medication in high doses can be associated with memory impairment in dystonia. The successful treatment of dystonia with botulinum toxin injections or deep brain stimulation does not produce any major adverse effects on cognition. The aspects of cognition that require further investigation in future studies of dystonia include inhibitory control, decision making, and social cognition. © 2017 International Parkinson and Movement Disorder Society
Optical molecular imaging‐guided radiation therapy part 2: Integrated x‐ray and fluorescence molecular tomography
Authors: Shi Junwei , Udayakumar Thirupandiyur S. , Wang Zhiqun , Dogan Nesrin , Pollack Alan , Yang Yidong 
Published: June 2017

PurposeDifferentiating tumor from its surrounding soft tissues is challenging for x‐ray computed tomography (CT). Fluorescence molecular tomography (FMT) can directly localize the internal tumors targeted with specific fluorescent probes. A FMT system was developed and integrated onto a CT‐guided irradiator to improve tumor localization for image‐guided radiation.MethodsThe FMT system was aligned orthogonal to the cone‐beam CT onboard our previously developed image‐guided small animal arc radiation treatment system (iSMAART). Through rigorous physical registration, the onboard CT provides accurate surface contour which is used to generate three‐dimensional mesh for FMT reconstruction. During FMT experiments, a point laser source perpendicular to the rotating axis was used to excite the internal fluorophores. The normalized optical images from multiple projection angles were adopted for tomographic reconstruction. To investigate the accuracy of the FMT in locating the tumor and recovering its volume, in vivo experiments were conducted on two breast cancer models: MDA‐MB‐231 cancer xenograft on nude mice and 4T1 cancer xenograft on white mice. Both cancer cell lines overexpress the epidermal growth factor receptor (EGFR). A novel fluorescent poly(lactic‐co‐glycolic) acid (PLGA) nanoparticle conjugated with anti‐EGFR was intravenously injected to specifically target the breast cancer cells. Another ex vivo experiment on a mouse bearing a surgically implanted Indocyanine Green‐containing glass tube was conducted, to additionally validate the precision of FMT‐guided radiation therapy.ResultsThe FMT can accurately localize the single‐nodule breast tumors actively targeted with fluorescent nanoparticles with localization error < 0.5 mm calculated between the centers of mass of tumors in FMT and CT. The reconstructed tumor volume in FMT was significantly correlated with that in the iodinated contrast‐enhanced CT (R2 = 0.94, P < 0.001). The FMT was able to guide focal radiation delivery with submillimeter accuracy.ConclusionUsing the tumor‐targeting fluorescent probes, the iSMAART with onboard FMT system can accurately differentiate tumors from their surrounding soft tissue, guide precise focal radiation delivery, and potentially assess tumor response in cancer research.
Presence of time‐dependent diffusion in the brachial plexus
Authors: Mahbub Zaid B. , Peters Andrew M. , Gowland Penny A. 
Published: June 2017

PurposeThis work describes the development of a method to measure the variation of apparent diffusion coefficient (ADC) with diffusion time (Δ) in the brachial plexus, as a potential method of probing microstructure.MethodsDiffusion‐weighted MRI with body signal suppression was used to highlight the nerves from surrounding tissues, and sequence parameters were optimized for sensitivity to change with diffusion time. A porous media‐restricted diffusion model based on the Latour‐Mitra equation was fitted to the diffusion time‐dependent ADC data from the brachial plexus nerves and cord.ResultsThe ADC was observed to reduce at long diffusion times, confirming that diffusion was restricted in the nerves and cord in healthy subjects. T2 of the nerves was measured to be 80 ± 5 ms, the diffusion coefficient was found to vary from (1.5 ± 0.1) × 10−3 mm2/s at a diffusion time of 18.3 ms to (1.0 ± 0.2) × 10−3 mm2/s at a diffusion time of 81.3 ms.ConclusionA novel method of probing restricted diffusion in the brachial plexus was developed. Resulting parameters were comparable with values obtained previously on biological systems. Magn Reson Med 79:789–795, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Large coverage black‐bright blood interleaved imaging sequence (LaBBI) for 3D dynamic contrast‐enhanced MRI of vessel wall
Authors: Qi Haikun , Huang Feng , Zhou Zechen , Koken Peter , Balu Niranjan , Zhang Bida , Yuan Chun , Chen Huijun 
Published: June 2017

PurposeTo propose a large coverage black‐bright blood interleaved imaging sequence (LaBBI) for 3D dynamic contrast‐enhanced MRI (DCE‐MRI) of the vessel wall.MethodsLaBBI consists of a 3D black‐blood stack‐of‐stars golden angle radial acquisition with high spatial resolution for vessel wall imaging and a 2D bright‐blood Cartesian acquisition with high temporal resolution for arterial input function estimation. The two acquisitions were performed in an interleaved fashion within a single scan. Simulations, phantom experiments, and in vivo tests in three patients were performed to investigate the feasibility and performance of the proposed LaBBI.ResultsIn simulation tests, the estimated Ktrans and vp by LaBBI were more accurate than conventional bright‐blood DCE‐MRI with lower root mean square error in all the tested conditions. In phantom test, no signal interference was found on the 2D scan in LaBBI. Pharmacokinetic analysis of the patients’ data acquired by LaBBI showed that Ktrans was higher in fibrous tissue (0.0717 ± 0.0279 min−1), while lower in necrotic core (0.0206 ± 0.0040 min−1) and intraplaque hemorrhage (0.0078 ± 0.0007 min−1), compared with normal vessel wall (0.0273 ± 0.0052 min−1).ConclusionThe proposed LaBBI sequence, with high spatial and temporal resolution, and large coverage blood suppression, was promising to probe the perfusion properties of vessel wall lesions. Magn Reson Med 79:1334–1344, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Subject‐level reliability analysis of fast fMRI with application to epilepsy
Authors: Hao Yongfu , Khoo Hui Ming , von Ellenrieder Nicolas , Gotman Jean 
Published: June 2017

PurposeRecent studies have applied the new magnetic resonance encephalography (MREG) sequence to the study of interictal epileptic discharges (IEDs) in the electroencephalogram (EEG) of epileptic patients. However, there are no criteria to quantitatively evaluate different processing methods, to properly use the new sequence.MethodsWe evaluated different processing steps of this new sequence under the common generalized linear model (GLM) framework by assessing the reliability of results. A bootstrap sampling technique was first used to generate multiple replicated data sets; a GLM with different processing steps was then applied to obtain activation maps, and the reliability of these maps was assessed.ResultsWe applied our analysis in an event‐related GLM related to IEDs. A higher reliability was achieved by using a GLM with head motion confound regressor with 24 components rather than the usual 6, with an autoregressive model of order 5 and with a canonical hemodynamic response function (HRF) rather than variable latency or patient‐specific HRFs. Comparison of activation with IED field also favored the canonical HRF, consistent with the reliability analysis.ConclusionThe reliability analysis helps to optimize the processing methods for this fast fMRI sequence, in a context in which we do not know the ground truth of activation areas. Magn Reson Med 78:1–1, 2017. © 2016 International Society for Magnetic Resonance in Medicine
Sensory mapping of pelvic dermatomes in women with interstitial cystitis/bladder pain syndrome
Authors: Sanses Tatiana , McCabe Patrick , Zhong Ling , Taylor Aisha , Chelimsky Gisela , Mahajan Sangeeta , Buffington Tony , Hijaz Adonis , Ialacci Sarah , Janata Jeffrey , Chelimsky Thomas 
Published: June 2017

AimTo describe a sensory map of pelvic dermatomes in women with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). We hypothesized that if IC/BPS involves changes in central processing, then women with IC/BPS will exhibit sensory abnormalities in neurologic pelvic dermatomes.MethodsWomen with IC/BPS and healthy controls underwent neurologic examination that included evaluation of sharp pain sensitivity and vibration in dermatomes T12, L1, L2, S1‐5. Peripheral nervous system sensitivity to pressure, vibration, and pinprick were scored using numeric rating scales (NRS). Bilateral comparisons were made with Wilcoxon signed‐rank test and comparisons between groups were made by the Mann‐Whitney U‐test.ResultsTotal of 74 women with IC/BPS and 36 healthy counterparts were included. IC/BPS and control groups had similar age (43.0 ± 14.1 and 38.6 ± 15.3 years, P = 0.14) and BMI (28.9 ± 8.0 kg/m2 and 26.9 ± 8.4 kg/m2, P = 0.24), respectively. Women with IC/BPS reported hyperalgesia (elevated bilateral NRS pain intensity) in all pelvic dermatomes compared to healthy controls. S4‐S5 region had the highest pain intensity in all participants. All IC/BPS participants exhibited vibration sensation hypoesthesia, at least unilaterally, in all of the pelvic dermatomes except L1 compared to healthy controls.ConclusionThis detailed map of neurologic pelvic dermatomes in women with IC/BPS found hyperalgesia in all pelvic dermatomes, and some evidence of vibration sensation hypoesthesia, compared to healthy controls. These findings support the hypothesis that IC/BPS may involve changes in central signal processing biased towards nociception.
On the convergence of two‐level Krylov methods for singular symmetric systems
Authors: Erlangga Yogi A. , Nabben Reinhard 
Published: June 2017

SummaryWe discuss the convergence of a two‐level version of the multilevel Krylov method for solving linear systems of equations with symmetric positive semidefinite matrix of coefficients. The analysis is based on the convergence result of Brown and Walker for the Generalized Minimal Residual method (GMRES), with the left‐ and right‐preconditioning implementation of the method. Numerical results based on diffusion problems are presented to show the convergence.
Small Proteins Encoded by Unannotated ORFs are Rising Stars of the Proteome, Confirming Shortcomings in Genome Annotations and Current Vision of an mRNA
Authors: Delcourt Vivian , Staskevicius Antanas , Salzet Michel , Fournier Isabelle , Roucou Xavier 
Published: June 2017

AbstractShort ORF‐encoded peptides and small proteins in eukaryotes have been hiding in the shadow of large proteins for a long time. Recently, improved identifications in MS‐based proteomics and ribosome profiling resulted in the detection of large numbers of small proteins. The variety of functions of small proteins is also emerging. It seems to be the right time to reflect on why small proteins remained invisible. In addition to the obvious technical challenge of detecting small proteins, they were mostly forgotten from annotations and they escaped detection because they were not sought. In this review, we identify conventions that need to be revisited, including the assumption that mature mRNAs carry only one coding sequence. The large‐scale discovery of small proteins and of their functions will require changing some paradigms and undertaking the annotation of ORFs that are still largely perceived as irrelevant coding information compared to already annotated coding sequences.
Solvent controlling excited state proton transfer reaction in quinoline/isoquinoline‐pyrazole isomer QP‐I: A theoretical study
Authors: Yang Dapeng , Yang Guang , Zhao Jinfeng , Song Nahong , Zheng Rui , Wang Yusheng 
Published: June 2017

AbstractIn this present work, we theoretically study the excited state intramolecular proton transfer (ESIPT) mechanism about a quinoline/isoquinoline‐pyrazole isomerQP‐Isystem. Compared with previous experimental results, our calculated results reappear previous data, which further confirm the theoretical level we used is reasonable. We mainly adopt 2 kinds of solvents (nonpolar cyclohexane and polar acetonitrile) to explore solvents effects on this system. Through reduced density gradient (RDG) function, the intramolecular hydrogen bond N1─H2···N3 has been confirmed existing in both S0and S1states, although the distance between H2 and N3 is not short. In addition, the strengthening N1─H2···N3 in the S1state provides possibility for ESIPT. Explorations about charge redistribution reveal the trend of ESIPT, and frontier orbital gap reflects the reactivity in polar and nonpolar solvents. The constructing potential energy curves reveal that potential energy barriers could be controlled and regulated by solvent polarity.
European corn borer (Ostrinia nubilalis Hbn., Lepidoptera: Crambidae): comparing the performance of a new bisexual lure with that of synthetic sex pheromone in five countries
Authors: Tóth Miklós , Szarukán István , Nagy Antal , Furlan Lorenzo , Benvegnù Isadora , Rak Cizej Magda , Ábri Tamás , Kéki Tamás , Körösi Szilvia , Pogonyi Attila , Toshova Teodora , Velchev Dimitar , Atanasova Daniela , Kurtulus Alican , Kaydan Bora Mehmet , Signori Alessio 
Published: June 2017

AbstractBACKGROUNDPhenylacetaldehyde is a flower volatile and attractant for among others the European corn borer Ostrinia nubilalis. The addition of 4‐methoxyphenethyl alcohol has recently been reported to increase O. nubilalis catches four to five times, yielding a bisexual lure for the species.RESULTSThe bisexual lure significantly outperformed synthetic pheromone lures of O. nubilalis at 11 out of 13 experiments conducted in Bulgaria, Hungary, Italy, Slovenia and Turkey.CONCLUSIONThe bisexual lure will provide growers with a new and efficient method for detection and monitoring of O. nubilalis. © 2017 Society of Chemical Industry
Insecticide resistance and intracellular proteases
Authors: Wilkins Richard M 
Published: June 2017

AbstractPesticide resistance is an example of evolution in action with mechanisms of resistance arising from mutations or increased expression of intrinsic genes. Intracellular proteases have a key role in maintaining healthy cells and in responding to stressors such as pesticides. Insecticide‐resistant insects have constitutively elevated intracellular protease activity compared to corresponding susceptible strains. This increase was shown for some cases originally through biochemical enzyme studies and subsequently putatively by transcriptomics and proteomics methods. Upregulation and expression of proteases have been characterised in resistant strains of some insect species, including mosquitoes. This increase in proteolysis results in more degradation products (amino acids) of intracellular proteins. These may be utilised in the resistant strain to better protect the cell from stress. There are changes in insect intracellular proteases shortly after insecticide exposure, suggesting a role in stress response. The use of protease and proteasome inhibitors or peptide mimetics as synergists with improved application techniques and through protease gene knockdown using RNA interference (possibly expressed in crop plants) may be potential pest management strategies, in situations where elevated intracellular proteases are relevant. © 2017 Society of Chemical Industry
New technology for using meteorological information in forest insect pest forecast and warning systems
Authors: Qin Jiang‐Lin , Yang Xiu‐Hao , Yang Zhong‐Wu , Luo Ji‐Tong , Lei Xiu‐Feng 
Published: June 2017

AbstractBACKGROUNDNear surface air temperature and rainfall are major weather factors affecting forest insect dynamics. The recent developments in remote sensing retrieval and geographic information system spatial analysis techniques enable the utilization of weather factors to significantly enhance forest pest forecasting and warning systems. The current study focused on building forest pest digital data structures as a platform of correlation analysis between weather conditions and forest pest dynamics for better pest forecasting and warning systems using the new technologies.RESULTSThe study dataset contained 3 353 425 small polygons with 174 defined attributes covering 95 counties of Guangxi province of China currently registering 292 forest pest species. Field data acquisition and information transfer systems were established with four software licences that provided 15‐fold improvement compared to the systems currently used in China. Nine technical specifications were established including codes of forest districts, pest species and host tree species, and standard practices of forest pest monitoring and information management. Attributes can easily be searched using ArcGIS9.3 and/or the free QGIS2.16 software.CONCLUSIONSSmall polygons with pest relevant attributes are a new tool of precision farming and detailed forest insect pest management that are technologically advanced. © 2017 Society of Chemical Industry
Event‐triggered probabilistic robust control of linear systems with input constrains: By scenario optimization approach
Authors: Yin Yanyan , Liu Yanqing , Teo Kok Lay , Wang Song 
Published: June 2017

SummaryThis paper addresses the problem of probabilistic robust stabilization for uncertain systems subject to input saturation. A new probabilistic solution framework for robust control analysis and synthesis problems is addressed by a scenario optimization approach, in which the uncertainties are not assumed to be norm bounded. Furthermore, by expressing the saturated linear feedback law on a convex hull of a group of auxiliary linear feedback laws, we establish conditions under which the closed‐loop system is probabilistic stable. Based on these conditions, the problem of designing the state feedback gains for achieving the largest size of the domain of attraction is formulated and solved as a constrained optimization problem with linear matrix inequality constraints. The results are then illustrated by a numerical example.
The automatic creation of OLAP cube using an MDA approach
Authors: Letrache Khadija , El Beggar Omar , Ramdani Mohammed 
Published: June 2017

SummaryThe Model‐Driven Architecture (MDA) is an approach that aligns modeling and automation for software development. By applying such an approach to data warehouse (DW) projects, we can minimize a great deal of time and cost. Furthermore, most of OnLine Analytical Processing (OLAP) platforms seem to be like black boxes that provide wizards only to business intelligence developers to create and manipulate OLAP objects without allowing their sustainability and migration from a platform to another. That is why many works in the literature have proposed using the MDA approach in DW projects. However, most of them have mainly focused on the generation of the DW relational model from the conceptual one, and they overlooked the OLAP model and the cube implementation.To deal with this problem, we propose in this paper an MDA solution to automate the process of getting OLAP cube and its implementation through a set of metamodels and automatic transformations among them. In fact, the proposal generates the OLAP and DW relational models (PSMs) from the conceptual one, using also a PDM model that describes the target business intelligence platform. After that, the source code to create the cube is got from both PSM models. For this aim, we define a set of transformation rules implemented using the Atlas transformation language. Finally, a case study will be provided to validate our approach.
Effects of road construction noise on golden‐cheeked warblers: An update
Authors: Long Ashley M. , Colón Melanie R. , Bosman Jessica L. , Mcfarland Tiffany M. , Locatelli Anthony J. , Stewart Laura R. , Mathewson Heather A. , Newnam John C. , Morrison Michael L. 
Published: June 2017

ABSTRACTPreviously, we reported results from an impact assessment that examined the effects of road construction noise on habitat selection and productivity of an endangered songbird, the golden‐cheeked warbler (Setophaga chrysoparia; warbler hereafter), in rural Texas, USA. We found no evidence that road construction or traffic noise negatively influenced warbler territory density, territory placement, pairing success, or fledging success during 3 years of road construction activities (2007–2009). In addition, warblers exhibited few acute responses to construction noise played at close range (2008–2009). Herein, we expanded on previous results to include an additional year of construction data (2010) and 3 years of post‐construction data (2011–2013) because birds may exhibit delayed responses to disturbance. We also examined the potential influence of road construction noise and activity on warbler song characteristics because birds may sing at higher minimum frequencies if loud noise masks their communication signals. Similar to previous findings, we found no evidence that road construction or traffic noise negatively influenced warblers in our rural study area. However, noise levels varied little across experimental and control study sites, with increasing distance from the road, or between the construction and post‐construction phases of our study. Warblers may respond negatively to louder noise or other disturbances that accompany construction activities (e.g., vibrations), but our comparisons across study sites, the results of our playback experiment, and data collected during concurrent studies in urban Texas and on military land suggest this is unlikely. © 2017 The Wildlife Society.
Isotopic analysis of epidermal mucus in freshwater fishes can reveal short‐time diet variations
Authors: Shigeta Kanji , Tsuma Shiori , Yonekura Ryuji , Kakamu Hiroto , Maruyama Atsushi 
Published: June 2017

AbstractAlthough stable isotope analysis is a powerful tool for determining animal diets, migration patterns, and the structure of food webs in aquatic systems, the slow response of isotopic ratios in the traditionally used muscle tissue of fishes often hampers this approach. By analyzing tissues with more rapid isotopic change, this technique can be used over a finer time scale than traditional isotopic analyses. We conducted a diet‐switch experiment to compare changes in the stable carbon and nitrogen isotope ratio values (δ13C and δ15N, respectively) in epidermal mucus, fin and muscle tissues of three species of freshwater cyprinid fishes. The half‐life of the isotopic change ranged from 62 to 144 days in mucus, 57 to 202 days in fin, and 196 to 680 days in the muscle tissue. The isotope ratios in mucus changed more rapidly than those in muscle tissues in the three species examined, similarly to the previously studied three species (catfish, steelhead, freshwater goby), whereas fin showed relatively variable trends in isotopic change. Interspecific variation in the trophic discrimination factor (TDF) was particularly large in the δ13C values of fin tissue compared with those in the other two tissues. With generally rapid change and relatively invariable TDF, the use of epidermal mucus in isotope analysis instead of the widely used fin and muscle tissues is advantageous for studying short‐term changes in food habits of fishes and food web structures.