bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paramedics’ anxiety and concerns around traumatic events: a Delphi study
Authors: Alshamrani Abdullah , Gosling Cameron , Alzobaidi Sultan , Williams Brett 
Published: October 2024

Introduction: Trauma is a major problem in Saudi Arabia and a leading cause of mortality and morbidity. In 2018, road traffic injuries and trauma were the second-leading cause of death after ischaemic heart disease. There is a lack of research that explores the psychological effects on emergency medical service (EMS) professionals of providing prehospital care at trauma events. This study aims to identify which trauma cases cause the most anxiety and concern among EMS professionals. Methods: A study using a two-round Delphi method was undertaken online with EMS professionals working for the Saudi Red Crescent Authority. Results: In the initial round, one item—road traffic collision—achieved 70% consensus that it caused significant anxiety and concern; the second round did not achieve any consensus regarding other types of incident. Conclusion: Road traffic collisions are a leading cause of death and, based on the participants’ responses, they cause paramedics the most anxiety and concern of all case types.
Employing single-cell RNA sequencing coupled with an array of bioinformatics approaches to ascertain the shared genetic characteristics between osteoporosis and obesity
Authors: Liu Dingzhuo , Cao Fangming , Liu Dian , Li Hao , Tao Lin , Zhu Yue 
Published: October 2024

AimsThis study examined the relationship between obesity (OB) and osteoporosis (OP), aiming to identify shared genetic markers and molecular mechanisms to facilitate the development of therapies that target both conditions simultaneously.MethodsUsing weighted gene co-expression network analysis (WGCNA), we analyzed datasets from the Gene Expression Omnibus (GEO) database to identify co-expressed gene modules in OB and OP. These modules underwent Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and protein-protein interaction analysis to discover Hub genes. Machine learning refined the gene selection, with further validation using additional datasets. Single-cell analysis emphasized specific cell subpopulations, and enzyme-linked immunosorbent assay (ELISA), protein blotting, and cellular staining were used to investigate key genes.ResultsWGCNA revealed critical gene modules for OB and OP, identifying the Toll-like receptor (TLR) signalling pathway as a common factor. TLR2 was the most significant gene, with a pronounced expression in macrophages. Elevated TLR2 expression correlated with increased adipose accumulation, inflammation, and osteoclast differentiation, linking it to OP development.ConclusionOur study underscores the pivotal role of TLR2 in connecting OP and OB. It highlights the influence of TLR2 in macrophages, driving both diseases through a pro-inflammatory mechanism. These insights propose TLR2 as a potential dual therapeutic target for treating OP and OB.Cite this article: Bone Joint Res 2024;13(10):573–587.
Impact of pain on functional status and quality of life in Jordanian women with breast cancer
Authors: AL-Atiyyat Nijmeh , Salem Hanan Fakhri , Hamam Ammar Hisham Mustafa 
Published: October 2024

Background
Currently, breast cancer is the most prevalent type of cancer affecting women, and the number of newly diagnosed cases continues to increase both in Jordan and globally. Upon receiving a cancer diagnosis, the suffering experienced by patients intensifies as they grapple with the debilitating side effects that hinder their ability to carry out routine activities.

Purpose
This study aims to assess the impact of cancer pain on functional status and quality of life (QOL) among Jordanian women with breast cancer.

Methods
A descriptive cross-sectional design and structured interviews were conducted in the Oncology Unit at Al-Bashir Hospital with a sample of 150 eligible Jordanian women with breast cancer who provided data on pain and functional status, and QOL using four Arabic questionnaires (brief pain inventory, functional status SF-12 questionnaire, and quality of life index) to measure pain and functional status and QOL, descriptive statistics, Pearson correlation, and regression statistical test were utilized to analyze the study data.

Results
A Significant positive correlation (r = 0.342) was found between cancer pain and functional status interference, a significant negative correlation (r = -0.134) between quality of life and functional status interference, and a significant negative correlation (r = -0.211) between pain and quality of life. Patients with higher intensity of cancer pain are more likely to experience low functional status and poor QOL.

Conclusion
Breast cancer patients experience alterations in their quality of life as a result of cancer-related pain, which has a detrimental impact on their ability to carry out daily activities and disrupts their functional abilities. Healthcare providers must take these alterations into account and effectively handle them. Understanding the relationship between cancer pain and breast cancer can aid nurses in managing symptoms and providing holistic care, ultimately improving the quality of life.
Effectiveness of health partners coordination for COVID-19 pandemic response in Nepal
Authors: Mishra Sangeeta Kaushal , Adhikari Samir Kumar , Sah Pavan Kumar , Gocotano Allison Eugenio , Neupane Subash , Thapa Barsha , Devkota Gaurav 
Published: October 2024

Background
Nepal established the health partner coordination for COVID-19 response based on national and international plans and framework to support information-sharing for decision- making and course correction. This paper aims to assess the performance of COVID-19 Health Partner Coordination response in Nepal by adopting coordination best practices and tools from the international humanitarian cluster system.

Methods
Secondary data from unpublished documents on health partner coordination for COVID-19 response in Nepal was collected and analysed from April 2023 to May 2023. The secondary data were from the review of the health partner coordination meetings conducted for COVID-19 response using a researcher-developed document review tool, responses of health partners on a survey tool adapted from the cluster coordination performance monitoring tool from the Global Health Cluster, and transcript of Focused Group Discussion among health partners. Descriptive analysis of quantitative information and thematic analysis with predefined themes of qualitative information were performed using MS Excel and MS Word respectively. A written approval from the Ministry of Health and Population and an ethical clearance from the Nepal Health Research Council was obtained before conducting the study.

Results
More than three-fifths of the meetings showed good results in conduction, process, participation, and documentation of meeting action points with improvement required for follow-up (22.2%). Assessment of health partner coordination subfunctions resulted in either ‘good’ (>75.0%) or ‘satisfactory’ (50.1%-75.0%) except for prioritization based on analyses, which was ‘unsatisfactory’ (<50%). Partners admired good practices of health partner coordination, pointed out some issues, and provided recommendations.

Conclusion
COVID-19 has highlighted the importance of effective coordination of health sector for response to a pandemic. Continuation of this practice after addressing the areas for improvement will contribute to health preparedness and readiness for future disasters or public health emergencies.
Asian Pacific Islander Desi American college students and COVID-19-related racial discrimination: Mental health and the moderating role of ethnic identity
Authors: Bañada Ronna , Oh Hans , Jang Yuri , Wu Shinyi , Javier Joyce , Liang Jiaming , Palinkas Lawrence A. 
Published: October 2024

Background
In 2020, the Coronavirus disease (COVID-19) triggered the latest wave of anti-Asian discrimination. During the first year of the pandemic, symptoms of depression and anxiety increased seven-fold within Asian Pacific Islander Desi American (APIDA) communities. Among this population, APIDA college students were at particularly high risk for mental health challenges due to COVID-19-related racial discrimination. This study examined the association between COVID-19-related racial discrimination and the mental health of APIDA college students, conceptualizing ethnic identity as a moderator in the association.

Methods
Secondary analysis was conducted on data from 2,559 APIDA college students aged 18 to 29 who participated in the Fall and Winter/Spring Cohorts of the 2020–2021 Healthy Minds Study (HMS), a non-probability web-based survey administered to students in higher education in the United States. Descriptive statistics, comparative analysis (e.g., Chi-square and t-test), and multivariable linear regression were conducted using STATA 17.1 (StataCorp LLC, College Station, TX). Survey weights were applied in all analyses.

Results
There were significant positive associations between COVID-19-related racial discrimination and symptoms of depression (b = 2.15, p < 0.001) and anxiety (b = 1.81, p < 0.001) among the overall sample. Furthermore, a greater sense of ethnic identity was associated with lower symptoms of depression (b = -0.15, p< 0.001) among the overall sample. Finally, ethnic identity buffered the association between COVID-19-related racial discrimination and symptoms of anxiety among East Asian students and symptoms of both depression and anxiety among Native Hawaiian and Pacific Islander students. In contrast, ethnic identity intensified the association between COVID-19-related racial discrimination and symptoms of depression among Filipino students.

Conclusions
The research found that COVID-19-related racial discrimination was associated with increased symptoms of depression and anxiety among the full sample of APIDA college students during the first year of the pandemic. Additionally, higher levels of ethnic identity were associated with decreased depression among the entire group. The striking results on the moderating role of ethnic identity among subgroups call for further research on the ethnic identity development of APIDA college students, to help mitigate the effects of racial discrimination within a variety of systemic, complex, and dynamic sociocultural contexts.
Teaching and learning clinical reasoning skill in undergraduate medical students: A scoping review
Authors: Delavari Somayeh , Barzkar Farzaneh , M. J. P. Rikers Remy , Pourahmadi Mohammadreza , Soltani Arabshahi Seyed Kamran , Keshtkar Abbasali , Dargahi Helen , Yaghmaei Minoo , Monajemi Alireza 
Published: October 2024

Background
Clinical reasoning involves the application of knowledge and skills to collect and integrate information, typically to arrive at a diagnosis, implement appropriate interventions, solve clinical problems, and improve the quality of health care and patient outcomes. It is a vital competency that medical students must acquire, as it is considered the heart of medicine.

Purpose
This scoping review aimed to identify and summarize the existing literature on learning and teaching strategies for improving clinical reasoning skill in undergraduate medical education.

Methods
We conducted electronic searches in Scopus, PubMed/Medline (NLM), Web of Science (WOS), and ERIC to retrieve articles published between January 1, 2010, and March 23, 2024. We also performed hand searches by scanning the reference lists of included studies and similar reviews and searching three key journals. After removing duplicates, two reviewers independently extracted data from primary articles using a standard data extraction form. The authors used Arksey and O’Malley’s framework.

Results
Among the 46581 retrieved records, 54 full-text articles were included in the present review. We categorized the educational strategies based on their aspects, focus, and purpose. Included studies used various educational strategies for improving clinical reasoning skill in undergraduate medical education by serial cue or whole clinical cases that presented as process-oriented or knowledge-oriented.

Conclusion
This scoping review investigated various dimensions of educational intervention for improving clinical reasoning skill in undergraduate medical education. There is a need for more precision studies with larger sample sizes, designing studies according to randomized controlled trials standards, determining MCID, or performing meta-analyses to acquire robust and conclusive results.
The association between dietary carbohydrate intake and the risk of hyperlipidemia among reproductive-aged women in the US: A cross-sectional study
Authors: Zhao Minli , Zhang Qiuping , Lin Yuan , Zhang Danwei , Cao Hua 
Published: October 2024

Background
The association between dietary carbohydrate intake and hyperlipidemia remained incompletely understood. This study aimed to explore the association between dietary carbohydrate intake and the risk of hyperlipidemia among reproductive-aged women in the US.

Methods
The study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2020. Dietary intake information was assessed via interviews using 24-hour dietary recall interviews, and hyperlipidemia diagnosis adhered to the National Cholesterol Education Program guidelines. Univariate and multivariate logistic regression analyses, along with restricted cubic splines (RCS) and stratified analyses, were conducted to investigate the association between dietary carbohydrate intake and the risk of hyperlipidemia.

Results
A total of 6,791 women of reproductive age, with a mean age of 34.87 (±8.57) years, were included in the final analysis. In the multivariate logistic regression model adjusting for covariates, a higher percentage of energy from carbohydrate was positively correlated with the risk of hyperlipidemia (adjusted odds ratio (AOR): 1.014, 95% CI: 1.004–1.024). Analyzing the percentage of energy from carbohydrate as a categorical variable, compared to the lowest quartile, the third quartile (AOR: 1.263, 95% CI: 1.031–1.546) and the highest quartile (AOR: 1.411, 95% CI: 1.083–1.839) were associated with increased hyperlipidemia risk. Additionally, a linear relationship (P for nonlinearity = 0.088) existed between the percentage of energy from carbohydrate and the risk of hyperlipidemia, with an inflection point identified at 49.64.

Conclusions
This study found that elevated dietary carbohydrate intake was associated with an increased the risk of hyperlipidemia in reproductive-aged women. These findings implied that reproductive-aged women should pay closer attention to reducing their carbohydrate intake.
Association between self-reported napping and risk of cardiovascular disease and all-cause mortality: A meta-analysis of cohort studies
Authors: Wang Meng , Xiang Xin , Zhao Zhengyan , liu Yu , Cao Yang , Guo Weiwei , Hou Linlin , Jiang Qiuhuan 
Published: October 2024

Objectives
This meta-analysis aims to assess the association between adult nap duration and risk of all-cause mortality and cardiovascular diseases (CVD).

Methods
PubMed, Cochrane Library, Embase and Web of Science databases were searched to identify eligible studies. The quality of observational studies was assessed using the Newcastle-Ottawa Scale. We performed all statistical analyses using Stata software version 14.0. For the meta-analysis, we calculated hazard ratio (HR) and their corresponding 95% confidence intervals (CIs). To assess publication bias, we used a funnel plot and Egger’s test.

Results
A total of 21 studies involving 371,306 participants revealed varying methodological quality, from moderate to high. Those who indulged in daytime naps faced a significantly higher mortality risk than non-nappers (HR: 1.28; 95% CI: 1.18–1.38; I2 = 38.8%; P<0.001). Napping for less than 1 hour showed no significant association with mortality (HR: 1.00; 95% CI: 0.90–1.11; I2 = 62.6%; P = 0.971). However, napping for 1 hour or more correlated with a 1.22-fold increased risk of mortality (HR: 1.22; 95% CI: 1.12–1.33; I2 = 40.0%; P<0.001). The risk of CVD associated with napping was 1.18 times higher than that of non-nappers (HR: 1.18; 95% CI: 1.02–1.38; I2 = 87.9%; P = 0.031). Napping for less than 1 hour did not significantly impact CVD risk (HR: 1.03; 95% CI: 0.87–1.12; I2 = 86.4%; P = 0.721). However, napping for 1 hour or more was linked to a 1.37-fold increased risk of CVD (HR: 1.37; 95% CI: 1.09–1.71; I2 = 68.3%; P = 0.007).

Conclusions
Our meta-analysis indicates that taking a nap increases the risk of overall mortality and CVD mortality. It highlights that the long duration time of the nap can serve as a risk factor for evaluating both overall mortality and cardiovascular mortality.
Effect of telomere shortening on disease progression in patients with inflammatory bowel disease: A systematic review and meta-analysis protocol
Authors: Zhang Yifan , Ma Ze , Kang Liang , Yang Liu 
Published: October 2024

Introduction
Inflammatory bowel disease (IBD) remains a major public health challenge worldwide. In recent years, it has been discovered that a link between telomere shortening and disease progression in IBD patients has been present. However, there is controversy as to whether telomere shortening precipitates disease progression or disease progression causes telomere shortening. There is also a shortage of systematic reviews and data synthesis to explain the association between telomere shortening and disease progression in individuals with IBD. We aimed to systematically review the association between telomere shortening and disease advancement in individuals with IBD to inform future studies.

Methods and analysis
We will undertake a thorough search of the electronic database from the beginning until December 31, 2023. We will search the databases: MEDLINE/PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), VIP, Wanfang Database (Wanfang), CMB, Cochrane Library, Cochran Clinical Trials Registry, and the World Health Organization International Clinical Trials Registry Platform. Two reviewers will assess the discovered citations for eligibility based on the title and abstract before proceeding to the full-text and data extraction phases. These reviewers will debate and settle any conflicts that arise during the inclusion process; a third reviewer will settle any issues that remain. The validated data extraction form will be used to collect data for eligible research. The included studies will undergo a quality and bias check and will proceed meta-analysis.

Discussion
This systematic review and meta-analysis will reveal a positive correlation between illness progression and telomere shortening in individuals with IBD, perhaps demonstrating three causal links between them. This study will conduct the first systematic review and meta-analysis examining the correlation between telomere shortening and illness advancement in individuals with IBD. Exploring the connection between these two situations can enhance the comprehension of the development and advancement of IBD.

Systematic review registration
PROSPERO registration number: CRD42024501171.
Low-molecular-weight heparin in the prevention of venous thromboembolism among patients with acute intracerebral hemorrhage: A meta-analysis
Authors: Li Haizheng , Wu Zhiguo , Zhang Hongyu , Qiu Baohua , Wang Yajun 
Published: October 2024

Objective
It remains unclear whether low-molecular-weight heparin (LMWH) is effective and safe for intracerebral hemorrhage (ICH) patients. This study presents a meta-analysis for elucidating effect of LMWH on preventing venous thromboembolism (VTE) among ICH patients.

Methods
Articles were located by systematically searching PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), WANFANG DATA, VIP, and SinoMed databases. The literature was independently screened by two authors, who also extracted data and conducted a qualitative evaluation. With regard to outcomes, their risk ratios (RRs) and 95% confidence intervals (CIs) were computed, and the findings were combined using the random effects model by using Mantel-Haenszel approach.

Results
30 studies involving 2904 patients were analyzed and compared to control group. According to our findings, early low-dose LMWH, prophylaxis for VTE, was related to the markedly reduced deep vein thrombosis (DVT) (3.6% vs. 17.5%; RR, 0.25; 95% CI, 0.18–0.35; p-value<0.00001) and pulmonary embolism (PE) (0.4% vs. 3.2%; RR, 0.29; 95% CI, 0.14–0.57; p-value = 0.003), while the non-significantly increased hematoma progression (3.8% vs. 3.4%; RR, 1.06; 95% CI, 0.68–1.68; p-value = 0.79) and gastrointestinal bleeding (3.6% vs. 6.1%; RR, 0.63; 95% CI, 0.31–1.28; p-value = 0.20). Also, mortality (14.1% vs. 15.8%; RR, 0.90; 95% CI, 0.63–1.28; p-value = 0.55) did not show any significant difference in LMWH compared with control groups.

Conclusions
Our meta-analysis suggested that early low-dose of LMWH are safe and effective in ICH patients. More extensive, multicenter, high-quality randomized clinical trials (RCTs) should be conducted to validate the findings and inform clinical practice.
Apuntes sobre Hannah Arendt como historiadora de la cultura
Authors: Fuster Peiró À. Lorena 
Published: October 2024

Este artículo pretende abrir una vía de investigación para explorar en qué sentido la metodología y algunas de las obras de Hannah Arendt pueden ser interpretadas como formas de historia cultural. Esta primera incursión se realizará, en especial, a partir del estudio de tres escritos que coinciden en su época de publicación Rahel Varnhagen (1957), La condición humana (1958) y «Cultura y política» (1959) y que tratan desde diferentes aristas el tema de la relación entre la cultura y la política: desde el vínculo entre la socialización de la cultura y la asimilación judía, desde la posición del arte en las actividades de la vita activa y desde la su teoría política y sus reflexiones sobre la crisis en la cultura.
Arvydas Šliogeris’ Perspective on Place: Shaping the Cosmopolis for a Sustainable Presence
Authors: Daknys Mantas , Kardelis Naglis 
Published: October 2024

Abstract
This article explores the Lithuanian philosophical conception of philotopy by Arvydas Šliogeris, which, emphasizing the significance of place and experience, imposes limits on Nihil. Philotopy, as conceived by Šliogeris, is a novel method of contemporary philosophy, it is a possible answer to present-day challenges, both existential and environmental. The cosmopolis, as a concentration of things close to humans, primarily allows them to realize their finitude, similar to their place and the things closest to them. Consequently, this realization of the infinity of virtuality extends to an awareness of language as Nihilistic equipment. This mode of thinking also proves to be ecologically beneficial, as it de-virtualizes the individual and establishes a cosmopolis, which remains the beacon of hope and the source of the will to return to the surface of things – because only there can one experience a sparing fullness. This work seeks to illustrate that the fundamental relationship with a place is shaped during childhood, often rooted in the home. Tuan’s phenomenological approach justifies the formation of philotopian thinking and its legitimacy. This article argues that the place becomes determinative not only through the relationship where one becomes accustomed to coexisting with the Other, but also in shaping the vocabulary. Research reveals that language, as the fundamental plane of connection with the world, is influenced by place.