bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstructive sleep apnea and postoperative complications among patients undergoing gynecologic oncology surgery
Authors: Bamgbade Olumuyiwa A. , Khaw Rong R. , Sawati Raisah S. , Holland Cathrine M. 
Published: March 2017

AbstractObjectiveTo investigate the prevalence of obstructive sleep apnea (OSA), physiological or risk factors associated with OSA, and OSA‐associated postoperative complications among patients undergoing gynecologic oncology surgery.MethodsA prospective observational study enrolled gynecologic oncology patients undergoing abdominal surgery at a center in the UK between August 2009 and January 2013. All patients underwent perioperative sleep oximetry for the diagnosis of OSA. Data assessed included the body mass index, the STOP‐Bang score, the Epworth Sleepiness Scale score, the apnea–hypopnea index, and postoperative complications. Associations were determined between preoperative OSA and postoperative OSA, postoperative complications, and risk factors such as body mass index, age, STOP‐Bang score, and Epworth score.ResultsAmong 160 participants, 72 (45.0%) were obese and 80 (50.0%) had OSA. Obesity, older age (more than 65 years), and a neck circumference of 40 cm or more were significantly associated with OSA. Overall, 58 (36.3%) patients had postoperative complications; 21 (13.1%) had surgical complications and 37 (23.1%) had medical complications. Complications were not associated with OSA (P=0.612). Four (2.5%) patients died; mortality was not associated with OSA (P=0.810).ConclusionOSA is common among gynecologic oncology patients. Portable sleep oximetry identifies gynecology patients who have OSA or require postoperative critical care. Obesity is associated with OSA, but OSA is not associated with postoperative complications in gynecologic oncology patients.
A cross‐sectional comparison of three guidelines for intrapartum cardiotocography
Authors: Bhatia Meena , Mahtani Kamal R. , Nunan David , Reddy Aparna 
Published: March 2017

AbstractObjectiveTo compare the cardiotocography classification systems outlined by the International Federation of Gynecology and Obstetrics (FIGO) in 2015 and the UK National Institute for Health and Care Excellence (NICE) in 2007 and 2014.MethodsA cross‐sectional observational study of cardiotocography practices at a UK hospital was conducted among labor ward staff (n=21) from November 1 to November 31, 2015. All observers classified ten cardiotocography traces according to the three guidelines using a bespoke form. Outcome measures included interobserver agreement (κ values), percentage agreement, intervention rate, and perceived ease of use.ResultsThe κ values were 0.38 (FIGO 2015), 0.37 (NICE 2007), and 0.34 (NICE 2014). The percentage agreement was identical across the three systems for both normal cardiotocography results (100.0%) and for intermediate or suspicious results (80.9%). By contrast, the percentage agreement for abnormal or pathological findings was 47.6% for NICE 2014, 76.2% for FIGO 2015, and 91.0% for NICE 2007 guidelines. Among 210 observations, intervention was deemed necessary for 48 (22.9%) for FIGO 2015, 29 (13.8%) for NICE 2014, and 56 (26.7%) for NICE 2007 guidelines. The FIGO 2015 system was considered the easiest to use by 13 (61.9%) observers.ConclusionInterobserver agreement of cardiotocography classification is suboptimal. The FIGO 2015 system offered favorable agreement scores, perceived ease of use, and a moderate intervention rate.
Mycophenolate Mofetil and Rapamycin Induce Apoptosis in the Human Monocytic U937 Cell Line Through Two Different Pathways
Authors: Nowak Maxime , Tardivel Sylviane , Nguyen‐Khoa Thao , Abreu Sonia , Allaoui Fatima , Fournier Natalie , Chaminade Pierre , Paul Jean‐Louis , Lacour Bernard 
Published: March 2017

ABSTRACTTransplant vasculopathy may be considered as an accelerated form of atherosclerosis resulting in chronic rejection of vascularized allografts. After organ transplantation, a diffuse intimal thickening is observed, leading to the development of an atherosclerosis plaque due to a significant monocyte infiltration. This results from a chronic inflammatory process induced by the immune response. In this study, we investigated the impact of two immunosuppressive drugs used in therapy initiated after organ transplantation, mycophenolate mofetil, and rapamycin, on the apoptotic response of monocytes induced or not by oxidized LDL. Here we show the pro‐apoptotic effect of these two drugs through two distinct signaling pathways and we highlight a synergistic effect of rapamycin on apoptosis induced by oxidized LDL. In conclusion, since immunosuppressive therapy using mycophenolate mofetil or rapamycin can increase the cell death in a monocyte cell line, this treatment could exert similar effects on human monocytes in transplant patients, and thus, prevent transplant vasculopathy, atherosclerosis development, and chronic allograft rejection. J. Cell. Biochem. 118: 3480–3487, 2017. © 2017 Wiley Periodicals, Inc.
Autochthonous and allochthonous contributions of organic carbon to microbial food webs in Svalbard fjords
Authors: Holding Johnna M. , Duarte Carlos M. , Delgado‐Huertas Antonio , Soetaert Karline , Vonk Jorien E. , Agustí Susana , Wassmann Paul , Middelburg Jack J. 
Published: March 2017

AbstractRising temperatures in the Arctic Ocean are causing sea ice and glaciers to melt at record breaking rates, which has consequences for carbon cycling in the Arctic Ocean that are yet to be fully understood. Microbial carbon cycling is driven by internal processing of in situ produced organic carbon (OC), however recent research suggests that melt water from sea ice and glaciers could introduce an allochthonous source of OC to the microbial food web with ramifications for the metabolic balance of plankton communities. In this study, we characterized autochthonous and allochthonous sources of OC to the Western Svalbard fjord system using stable isotopes of carbon. We quantified δ13C of eukaryotic and prokaryotic planktonic groups using polar lipid‐derived fatty acids as biomarkers in addition to measuring δ13C of marine particulate OC and dissolved OC from glacial runoff. δ13C of bacteria (−22.5‰) was higher than that of glacial runoff OC (−28.5‰) and other phytoplankton groups (−24.7 to −29.1‰), which suggests that marine bacteria preferentially use a third source of OC. We present a Bayesian three‐source δ13C mixing model whereby ∼ 60% of bacteria carbon is derived from OC in sea ice, and the remaining carbon is derived from autochthonous production and glacial‐derived OC. These results suggest that subsidies of OC from melting glaciers will not likely influence microbial carbon cycling in Svalbard fjords in the future and that further research is needed to determine the effects of melting sea ice on microbial carbon cycling in fjord systems and elsewhere in the Arctic Ocean.
Tribological properties of 2 novel Mo/B–based lubricant additives in polyalphaolefin
Authors: Huang Jiang‐Min , Qi He‐Dong , Gao Rui‐Bao , Zhang Guan‐Jun , Zhang Chen‐Xi , Yi Shou‐Zhi 
Published: March 2017

AbstractTwo kinds of Mo/B oleic diethanolamide derivatives (coded as YXM and YXB) were synthesised, and their tribological properties were evaluated using a 4‐ball machine. Results indicate that the 2 novel additives show excellent antiwear and extreme pressure properties. When 2.5 wt% YXM was added into the base oil, the wear scar diameter was reduced by 42.2%, and the PB value was increased by 170.4%; when 2.5 wt% YXB was added into the base oil, the wear scar diameter was reduced by 23.1%, and the PB value was increased by 167.1%. The worn surfaces of the lubricated GCr15 steel were analysed by using scanning electron microscopy and X‐ray photoelectron spectroscopy. It is indicated that the variation of tribofilm species produced by a chemical reaction between the additives and the steel surface plays an important role in inhibiting wear and friction. A model was used to analyse the action mechanism. According to the analysis, the tribofilm is composed of an adsorption layer and a reaction layer, and it could effectively protect the steel surfaces from direct contact.
Involvement of oxidative stress in protocatechuic acid‐mediated bacterial lethality
Authors: Ajiboye Taofeek O. , Habibu Ramat S. , Saidu Kabiru , Haliru Fatimah Z. , Ajiboye Hikmat O. , Aliyu Najeeb O. , Ibitoye Oluwayemisi B. , Uwazie Judith N. , Muritala Hamdalat F. , Bello Sharafa A. , Yusuf Idris I. , Mohammed Aisha O. 
Published: March 2017

AbstractThe involvement of oxidative stress in protocatechuic acid‐mediated bacterial lethality was investigated. Minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) of protocatechuic acid against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus are 600 and 700 μg/ml, 600 and 800 μg/ml, and 600 and 800 μg/ml, respectively. The optical densities and colony‐forming units of protocatechuic acid‐treated bacteria decreased in time‐dependent manner. Protocatechuic acid (4× MIC) significantly increased the superoxide anion content of E. coli, P. aeruginosa, and S. aureus compared to dimethyl sulfoxide (DMSO). Superoxide dismutase, catalase, and NAD+/NADH in protocatechuic acid‐treated E. coli, P. aeruginosa, and S. aureus increased significantly when compared to DMSO. Conversely, level of reduced glutathione decreased in protocatechuic acid‐treated E. coli, P. aeruginosa, and S. aureus, while glutathione disulfide increased when compared to DMSO. Furthermore, malondialdehyde and fragmented DNA increased significantly following exposure to protocatechuic acid. Protocatechuic acid inhibited the activity of complexes I and II. From the above findings, protocatechuic acid enhanced the generation of reactive oxygen species (superoxide anion radical and hydroxyl radical) in E. coli, P. aeruginosa, and S. aureus, possibly by autoxidation, fenton chemistry, and inhibiting electron transport chain resulting in lipid peroxidation and DNA fragmentation and consequentially bacterial cell death.
Metabolic engineering to expand the substrate spectrum of Pseudomonas putida toward sucrose
Authors: Löwe Hannes , Schmauder Lukas , Hobmeier Karina , Kremling Andreas , Pflüger‐Grau Katharina 
Published: March 2017

AbstractSucrose is an important disaccharide used as a substrate in many industrial applications. It is a major component of molasses, a cheap by‐product of the sugar industry. Unfortunately, not all industrially relevant organisms, among them Pseudomonas putida, are capable of metabolizing sucrose. We chose a metabolic engineering approach to circumvent this blockage and equip P. putida with the activities necessary to consume sucrose. Therefore, we constructed a pair of broad‐host range mini‐transposons (pSST – sucrose splitting transposon), carrying either cscA, encoding an invertase able to split sucrose into glucose and fructose, or additionally cscB, encoding a sucrose permease. Introduction of cscA was sufficient to convey sucrose consumption and the additional presence of cscB had no further effect, though the sucrose permease was built and localized to the membrane. Sucrose was split extracellularly by the activity of the invertase CscA leaking out of the cell. The transposons were also used to confer sucrose consumption to Cupriavidus necator. Interestingly, in this strain, CscB acted as a glucose transporter, such that C. necator also gained the ability to grow on glucose. Thus, the pSST transposons are functional tools to extend the substrate spectrum of Gram‐negative bacterial strains toward sucrose.
Tunable inductors using vanadium dioxide as the control material
Authors: Wang Shu , Wang Weisong , Shin Eunsung , Quach Tony , Subramanyam Guru 
Published: March 2017

ABSTRACTThis article experimentally studies the application of vanadium dioxide (VO2) thin film for tunable inductor design. VO2's temperature‐dependent conductivity is used for implementing a tunable inductor using VO2 as the control material. Two different configurations of inductors are designed. One design uses a short VO2 bar as a circuit switch and the other uses VO2 to replace the full spiral coil inductor. The frequency range in the experiments is 0.3–2 GHz. Experimental results show a 32% tuning range (1–0.68 nH) through applied temperature variation (25–100°C) in the devices. These results are matched by a working circuit π model. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1057–1061, 2017
A dual‐wideband dual‐polarized directional magneto‐electric dipole antenna
Authors: Yang Lei , Weng Zibin , Zhang Chi , Du Ruonan 
Published: March 2017

ABSTRACTA broadband dual‐band dual‐polarized directional magneto‐electric (ME) dipole antenna is presented in this letter. The antenna is composed of a square reflector, four side walls, a metallic loop, and two crossed ME dipoles fed by two orthogonal Γ‐shaped feed strips. Both simulated and measured results show that the antenna can obtain two wide impedance bandwidths of 18% (800–960 MHz) in lower frequency band and 45% (1700–2700 MHz) in higher frequency band with the reflection coefficients lower than −10 dB for both input ports. Meanwhile, about 25 dB isolation and 8 dBi gain are realized through the whole bands. The proposed antenna also demonstrates good directional radiation and cross‐polarization characteristics. Generally, the antenna can be widely used for 2G, 3G, LTE, and WLAN .etc communication systems. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1128–1133, 2017
Nerve conduction velocity and cross‐sectional area in ulnar neuropathy at the elbow
Authors: Podnar Simon , Omejec Gregor , Bodor Marko 
Published: March 2017

ABSTRACTIntroductionIn the precise localization of ulnar neuropathy at the elbow (UNE) we have noted discrepancies between electrodiagnostic (EDx) and ultrasonographic (US) findings. We aimed to explore the relationship between the 2 techniques.MethodsFour study‐blind examiners took a history and performed neurologic, EDx, and US examinations of a group of prospectively recruited patients with UNE. They assessed the relationship between ulnar nerve cross‐sectional area (CSA) and motor nerve conduction velocity (MNCV).ResultsIn 106 patients with UNE at the retrocondylar (RTC) groove, the highest CSA and lowest MNCV were noted in the same short segment. In 54 patients with UNE at the humeroulnar aponeurosis (HUA), the highest CSA and lowest MNCV were noted proximal to the HUA.DiscussionMNCV and CSA were highly correlated in UNE. Ulnar nerve slowing proximal to the entrapment at the HUA was surprising, but consistent with previous studies done on carpal tunnel syndrome. Muscle Nerve 56: E65–E72, 2017
Effect of lorcaserin on glycemic parameters in patients with type 2 diabetes mellitus
Authors: Magkos Faidon , Nikonova Elena , Fain Randi , Zhou Sharon , Ma Tony , Shanahan William 
Published: March 2017

ObjectiveLorcaserin, a 5‐HT2C receptor agonist approved for chronic weight management, is also associated with improvements in glycemic parameters in patients with/without type 2 diabetes mellitus (T2DM), but the extent to which these effects are mediated by weight loss is unknown. This post hoc analysis further examines glycemic data from the Phase III BLOOM‐DM study stratified by weight changes.MethodsPatients with T2DM were randomized to lorcaserin 10 mg twice daily or placebo. Glycemic parameters were reported by Week (W) 12 weight loss status ≥5% (Group ≥5%) or <5% (Group <5%). Glycemic parameter changes were analyzed using ANCOVA; the relationship between glycemic parameter changes and percent weight loss was assessed by simple regression modeling.ResultsGroup ≥5% receiving lorcaserin had greater improvements in fasting plasma glucose (FPG) at W2 (prior to significant weight loss) and greater improvements in glycated hemoglobin (HbA1c) at W12 versus placebo. These improvements were maintained through W52 (FPG, −29.3 mg/dL vs. −24.2 mg/dL; HbA1c, −1.2% vs. −1.1%). Group <5% treated with lorcaserin also had larger decreases in FPG (−28.3 mg/dL vs. −10.0 mg/dL) and HbA1c (−0.8% vs. −0.4%) at W52 versus placebo despite limited weight loss.ConclusionsLorcaserin may have beneficial effects on glycemic control with or without weight loss.
Outcomes of a Randomized Controlled Trial of Genomic Counseling for Patients Receiving Personalized and Actionable Complex Disease Reports
Authors: Sweet Kevin , Sturm Amy C. , Schmidlen Tara , McElroy Joseph , Scheinfeldt Laura , Manickam Kandamurugu , Gordon Erynn S. , Hovick Shelly , Scott Roberts J. , Toland Amanda Ewart , Christman Michael 
Published: March 2017

AbstractThere has been very limited study of patients with chronic disease receiving potentially actionable genomic based results or the utilization of genetic counselors in the online result delivery process. We conducted a randomized controlled trial on 199 patients with chronic disease each receiving eight personalized and actionable complex disease reports online. Primary study aims were to assess the impact of in‐person genomic counseling on 1) causal attribution of disease risk, 2) personal awareness of disease risk, and 3) perceived risk of developing a particular disease. Of 98 intervention arm participants (mean age = 57.8; 39% female) randomized for in‐person genomic counseling, 76 (78%) were seen. In contrast, control arm participants (n= 101; mean age = 58.5; 54% female) were initially not offered genomic counseling as part of the study protocol but were able to access in‐person genomic counseling, if they requested it, 3‐months post viewing of at least one test report and post‐completion of the study‐specific follow‐up survey. A total of 64 intervention arm and 59 control arm participants completed follow‐up survey measures. We found that participants receiving in‐person genomic counseling had enhanced objective understanding of the genetic variant risk contribution for multiple complex diseases. Genomic counseling was associated with lowered participant causal beliefs in genetic influence across all eight diseases, compared to control participants. Our findings also illustrate that for the majority of diseases under study, intervention arm participants believed they knew their genetic risk status better than control arm subjects. Disease risk was modified for the majority during genomic counseling, due to the assessment of more comprehensive family history. In conclusion, for patients receiving personalized and actionable genomic results through a web portal, genomic counseling enhanced their objective understanding of the genetic variant risk contribution to multiple common diseases. These results support the development of additional genomic counseling interventions to ensure a high level of patient comprehension and improve patient‐centered health outcomes.
Effect of Weld Schedule on the Residual Stress Distribution of Boron Steel Spot Welds
Authors: Raath N. D. , Norman D. , McGregor I. , Dashwood R. , Hughes D. J. 
Published: March 2017

Abstract
Press-hardened boron steel has been utilized in anti-intrusion systems in automobiles, providing high strength and weight-saving potential through gage reduction. Boron steel spot welds exhibit a soft heat-affected zone which is surrounded by a hard nugget and outlying base material. This soft zone reduces the strength of the weld and makes it susceptible to failure. Additionally, different welding regimes lead to significantly different hardness distributions, making failure prediction difficult. Boron steel sheets, welded with fixed and adaptive schedules, were characterized. These are the first experimentally determined residual stress distributions for boron steel resistance spot welds which have been reported. Residual strains were measured using neutron diffraction, and the hardness distributions were measured on the same welds. Additionally, similar measurements were performed on spot welded DP600 steel as a reference material. A correspondence between residual stress and hardness profiles was observed for all welds. A significant difference in material properties was observed between the fixed schedule and adaptively welded boron steel samples, which could potentially lead to a difference in failure loads between the two boron steel welds.
Overview on the Middle to Upper Jurassic Sedimentary Succession of Gangta Bet in the Kachchh Basin, Western India, with Special Emphasis on its Lithostratigraphy, Biostratigraphy, and Palaeoenvironment
Authors: Alberti Matthias , Fürsich Franz T. , Pandey Dhirendra K. , Mukherjee Debahuti 
Published: March 2017

ABSTRACT
The Jurassic succession of Gangta Bet in the Kachchh basin of western India comprises around 130 m of mostly siliciclastic rocks. The strata belong to the Gangta Member of the Gadhada Formation and are herein sub-divided into four units: the Gangta sandstone beds, the lower silty sandstone beds, the upper silty sandstone beds, and the Gangta ammonite beds. These units can be separated by three marker horizons: the Brachiopod bed, the Gangta Conglomerate Bed, and the Gervillella Bed. Ammonites indicate an Oxfordian age for the upper half of the succession, but the scarcity of identifiable fossils in its basal part so far prevented precise biostratigraphic assignments. The shallow-water sediments can be interpreted as parasequences as a result of minor sea-level changes. Deposition took place close to the palaeo-coastline at water depths around the fair-weather wave-base.
Corbulid (Bivalvia) species from the Palaeogene Mangrol Lignite Mine of Surat, Gujarat
Authors: Roy Pinaki , Mukherjee Pratik 
Published: March 2017

ABSTRACT
Two corbulid species Caestocorbula gujaratensis var. mangroli and Caestocorbula gigantica are described here from the Mangrol Lignite Mine of Gujarat. Caestocorbula gigantica is the largest species within the corbulid clade. Detailed systematic description of the two species is the main stay of present endeavour. Since the two species have different overlapping morphologies, multivariate data analysis incorporating principal component analysis (PCA) and discriminant analysis (DA) have been applied in the present study. Application of PCA to test the variance among the morpho-metric data of the two species has been performed and the application of DA clearly separate the two species in spite of existence of correlation among the variables of two species.
Assessment of therapeutic effect of human choriogonadotropin in a chemical cystitis model
Authors: Tanik Serhat , Zengin Kürsad , Albayrak Sebahattin , Gurel Abdullah , Atar Muhittin , Sahin Sevinc , Tuzcu Nevin , Tuzcu Mehmet , Imamoglu Muhammet Abdurrahim , Gurdal Mesut 
Published: March 2017

AbstractIn this study, female rats induced with chemical cystitis were administered the hormone human choriogonadotropin (HCG), and it was aimed to reveal the usefulness of HCG in the treatment of interstitial cystitis/bladder pain syndrome. The materials for this study were 32 Wistar albino female rats. The study groups were formed as follows: the cystitis group (Group 1), the cystitis + HCG protection group (Group 2), the cystitis + HCG treatment group (Group 3), and the control group (Group 4), with eight rats in each group. In this study, blood and urine samples were taken from the rats, they were euthanized, and their bladders were removed for glutathione, malondialdehyde, tumor necrosis factor alpha, and interferon gamma measurements. It was observed that tissue damage in Group 2 was lower than that in the other two groups. Glutathione levels in Groups 2 and 4 were significantly higher than in Groups 1 and 3 (p = 0.01). Malondialdehyde levels of Groups 2 and 4 were significantly lower than the values in Groups 1 and 3 (p < 0.001). When the cystitis groups were compared in terms of their interferon gamma and tumor necrosis factor alpha levels, the lowest interferon gamma and tumor necrosis factor alpha levels were detected in Group 3. It was found that HCG has positive effects on experimental cystitis in rats. This study revealed that HCG should be researched as a therapeutic agent and formed a step for studies to be carried out on this subject.