bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of ultrasound in predicting birth‐weight discordance in twin pregnancy: systematic review and meta‐analysis
Authors: Leombroni M. , Liberati M. , Fanfani F. , Pagani G. , Familiari A. , Buca D. , Manzoli L. , Scambia G. , Rizzo G. , D'Antonio F. 
Published: November 2016

ABSTRACTObjectiveTo investigate the diagnostic performance of ultrasound in predicting birth‐weight (BW) discordance in twin pregnancy.MethodsElectronic databases PubMed, EMBASE and CINAHL were searched using combinations of MeSH terms ‘birth weight’, ‘discordance’, ‘twins’ and ‘ultrasound’. Summary estimates of sensitivity, specificity, positive and negative likelihood ratios and diagnostic odds ratios for the predictive accuracy of sonographically estimated fetal‐weight (EFW) discordance and abdominal‐circumference (AC) discordance in predicting BW discordance were computed using hierarchical summary receiver–operating characteristics curves.ResultsTwenty studies (including 5826 twin pregnancies) were included. EFW discordance ≥ 20% had a sensitivity of 65.4% and specificity of 90.8% in predicting BW discordance ≥ 20%. The predictive performance of ultrasound performed within 1 month, 2 weeks and 3 days before birth was 61.4%, 72.3% and 78.9%, respectively. EFW discordance ≥ 25% had a sensitivity of 57.7% and specificity of 95.2% in predicting BW discordance ≥ 25%. The sensitivity of EFW discordance ≥ 25% detected within 1 month, 2 weeks and 3 days before birth was 60.0%, 75.0% and 60.3%, respectively, while the corresponding values for specificity were 97.7%, 96.2% and 87.3%, respectively. In view of the different cut‐offs reported among studies, it was not possible to perform comprehensive data synthesis for each AC discordance cut‐off. The optimal diagnostic performance of AC discordance was for prediction of BW discordance ≥ 25%, with a sensitivity of 70.8% and specificity of 86.4%.ConclusionUltrasound EFW discordance has an overall moderate accuracy in predicting BW discordance in twin pregnancy. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Outcome of monochorionic twin pregnancy with selective intrauterine growth restriction according to umbilical artery Doppler flow pattern of smaller twin: systematic review and meta‐analysis
Authors: Buca D. , Pagani G. , Rizzo G. , Familiari A. , Flacco M. E. , Manzoli L. , Liberati M. , Fanfani F. , Scambia G. , D'Antonio F. 
Published: November 2016

ABSTRACTObjectiveTo explore the outcome of monochorionic twin pregnancies affected by selective intrauterine growth restriction (sIUGR) according to the umbilical artery Doppler pattern of the smaller twin.MethodsAn electronic search of MEDLINE, EMBASE, CINAHL and ClinicalTrials.gov databases (2000–2016) was performed. sIUGR was defined as the presence of one twin with an estimated fetal weight and/or abdominal circumference < 10th or < 5th percentile and classified according to the umbilical artery Doppler flow pattern of the smaller twin (Type I: persistently positive; Type II: persistently absent/reversed; Type III: intermittently absent/reversed). Primary outcomes were perinatal mortality, intrauterine death, neonatal death and double fetal loss. Secondary outcomes were neonatal morbidity, including abnormal postnatal brain imaging, intraventricular hemorrhage, periventricular leukomalacia, admission to neonatal intensive care unit and respiratory distress syndrome, deterioration of fetal status, gestational age at delivery and degree of birth‐weight discordance. A composite adverse outcome, defined as the presence of any mortality or abnormal brain findings, was also assessed. Quality assessment of the included studies was performed using the Newcastle–Ottawa Scale. A random‐effects meta‐analysis was used to compute the summary odds ratios (ORs), mean differences (MD) and proportions for the different outcomes.ResultsThirteen studies (610 pregnancies) were included. The risk of perinatal mortality was higher in twins affected by Type II compared with Type I sIUGR (OR, 4.1 (95% CI, 1.6–10.3)), whereas there was no difference among the other variants of growth restriction. Risk of abnormal postnatal brain imaging was significantly higher in twins affected by either Type II (OR, 4.9 (95% CI, 1.9–12.9)) or Type III (OR, 8.2 (95% CI, 2.0–33.1)) sIUGR compared with Type I sIUGR. The risk for neonatal intensive care unit admission was higher in Type II compared with Type I sIUGR (OR, 18.3 (95% CI, 1.0–339.7)). Twin pregnancies affected by Type I sIUGR were delivered at a significantly later gestational age compared with Type II (MD, 2.8 (95% CI, 1.83–3.86) weeks) and Type III (MD, 2.1 (95% CI, 0.97–3.19) weeks). The degree of birth‐weight discordance was higher in Type II compared with Type I (MD, 21.6% (95% CI, 9.9–33.2%)) and Type III (MD, 9.3% (95% CI, 3.8–14.9%)) sIUGR.ConclusionMonochorionic twin pregnancies affected by Type II sIUGR are at a higher risk of perinatal mortality and morbidity compared with Type I. The likelihood of an abnormal outcome is usually not significantly different between sIUGR Types II and III, although the latter has an unpredictable clinical course. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Simulating intra‐hourly wind power fluctuations on a power system level
Authors: Olauson Jon , Bergkvist Mikael , Rydén Jesper 
Published: November 2016

AbstractIn wind integration studies, sub‐hourly, load synchronous wind data are often preferable. These datasets can be generated by a hybrid approach, combining hourly measurements or output from meteorological models with a stochastic simulation of the high‐frequency fluctuations. This paper presents a method for simulating aggregated intra‐hourly wind power fluctuations for a power system, taking into account the time‐varying volatility seen in measurements. Some key elements in the modelling were transformations to stationarity, the use of frequency domain techniques including a search for appropriate phase angles and an adjustment of the resulting time series in order to get correct hourly means. Generation data from Denmark and Germany with 5 and 15 min temporal resolution were used for training models. It is shown that the distribution and non‐stationarity of simulated deviations from hourly means closely follow those of measurements. Power spectral densities and step change distributions agree well. Of particular importance is that the results are good also when the training and objective power systems are not the same. The computational cost is low in comparison with other approaches for generating high‐frequency data. Copyright © 2016 John Wiley & Sons, Ltd.
Serum Fatty Acid‐Binding Protein 4 is Increased in Patients with Psoriasis
Authors: Baran A. , Świderska M. , Bacharewicz‐Szczerbicka Joanna , Myśliwiec H. , Flisiak I. 
Published: November 2016

AbstractPsoriasis is associated with metabolic syndrome and cardiovascular disease. Fatty acid‐binding proteins (FABP) have been recognized as predictors of these systemic disorders. The aim of this study was to assess correlations between levels of serum heart and adipocyte fatty acid‐binding proteins (FABP3, FABP4) and disease severity, indicators of inflammation or metabolic disturbances, and topical treatment in psoriatic patients. Thirty‐seven patients with relapse of plaque‐type psoriasis and 16 healthy volunteers were recruited. Blood samples were collected before and after 14 days of therapy. Serum FABP concentrations were examined by enzyme‐linked immunosorbent assay for correlation with Psoriasis Area and Severity Index (PASI), body mass index (BMI), inflammatory or metabolic parameters, and treatment used. The median FABP4 serum levels were significantly increased (p = 0.038) in psoriatic patients, while FABP3 levels did not differ (p = 0.47) compared to the controls. No significant correlations were noted between the proteins and PASI, C‐reactive protein (CRP), BMI, or levels of glucose or lipids. FABP3 significantly correlated with white blood count (p = 0.03) and aspartate aminotransferase (p = 0.04). After topical treatment, there was no significant change in serum FABP3 [11.5 (4.9–30.3) vs. 12.9 (3.5–30.3) ng/ml] (p = 0.96), whereas FABP4 was decreased [27,286 (20,344–32,257) vs. 23,034 (18,320–29,874) pg/ml] (p = 0.12), losing its basal significance. FABP4 may be a marker of psoriasis, and FABP3 may be associated with inflammation or liver disorders in psoriatic patients. FABP do not appear to be useful for determining disease severity or the effectiveness of antipsoriatic treatment.
Fatty Acids from a Glass Sponge Aulosaccus sp. Occurrence of New Cyclopropane‐Containing and Methyl‐Branched Acids
Authors: Santalova Elena A. , Denisenko Vladimir A. 
Published: November 2016

AbstractIn order to identify new structures, the free fatty acids from an extract of a glass sponge Aulosaccus sp. (from the north‐west Pacific) belonging to one of the least chemically investigated classes (Hexactinellida), were fractionated by RP‐HPLC and analyzed by NMR spectroscopy and GC–MS of their pyrrolidine derivatives, methyl(ethyl) esters and their dimethyl disulfide adducts. One hundred and twenty‐three C12–C31 acids (including nine new compounds) were detected, one hundred and ten of these compounds have not been found previously in glass sponges. The levels of common methylene‐interrupted polyenes, monoenes of the (n–7) family and less common branched‐chain components proved to be high. New acids were shown to be 5,13‐dimethyl‐tetradec‐4‐enoic, cis‐10,11‐methylene‐heptadecanoic, 10,12‐dimethyl‐octadecanoic, cis‐12,13‐methylene‐nonadecanoic, (14E)‐13‐methyl‐eicos‐14‐enoic, 19‐methyl‐eicos‐13‐enoic, cis‐20,21‐methylene‐heptacosanoic, 27‐methyl‐octacos‐21‐enoic and (22Z)‐nonacos‐22‐enoic. Some important mass spectrometric characteristics of pyrrolidides of homologous cyclopropane fatty acids are reported and discussed.
STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease
Authors: Sachdev Perminder S. , Lo Jessica W. , Crawford John D. , Mellon Lisa , Hickey Anne , Williams David , Bordet Régis , Mendyk Anne‐Marie , Gelé Patrick , Deplanque Dominique , Bae Hee‐Joon , Lim Jae‐Sung , Brodtmann Amy , Werden Emilio , Cumming Toby , Köhler Sebastian , Verhey Frans R.J. , Dong Yan‐Hong , Tan Hui Hui , Chen Christopher , Xin Xu , Kalaria Raj N. , Allan Louise M. , Akinyemi Rufus O. , Ogunniyi Adesola , Klimkowicz‐Mrowiec Aleksandra , Dichgans Martin , Wollenweber Frank A. , Zietemann Vera , Hoffmann Michael , Desmond David W. , Linden Thomas , Blomstrand Christian , Fagerberg Björn , Skoog Ingmar , Godefroy Olivier , Barbay Mélanie , Roussel Martine , Lee Byung‐Chul , Yu Kyung‐Ho , Wardlaw Joanna , Makin Stephen J. , Doubal Fergus N. , Chappell Francesca M. , Srikanth Velandai K. , Thrift Amanda G. , Donnan Geoffrey A. , Kandiah Nagaendran , Chander Russell J. , Lin Xuling , Cordonnier Charlotte , Moulin Solene , Rossi Costanza , Sabayan Behnam , Stott David J. , Jukema J. Wouter , Melkas Susanna , Jokinen Hanna , Erkinjuntti Timo , Mok Vincent C.T. , Wong Adrian , Lam Bonnie Y.K. , Leys Didier , Hénon Hilde , Bombois Stéphanie , Lipnicki Darren M. , Kochan Nicole A. 
Published: November 2016

AbstractIntroductionThe Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD).MethodsLongitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia.ResultsCurrently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow‐up ranges from 3 months to 21 years.DiscussionAlthough data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.
Evaluation of α‐synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases
Authors: Llorens Franc , Kruse Niels , Schmitz Matthias , Gotzmann Nadine , Golanska Ewa , Thüne Katrin , Zejneli Orgeta , Kanata Eirini , Knipper Tobias , Cramm Maria , Lange Peter , Zafar Saima , Sikorska Beata , Liberski Pawel P. , Mitrova Eva , Varges Daniela , Schmidt Christian , Sklaviadis Theodoros , Mollenhauer Brit , Zerr Inga 
Published: November 2016

AbstractIntroductionAccurate diagnosis of prion diseases and discrimination from alternative dementias gain importance in the clinical routine, but partial overlap in cerebrospinal fluid (CSF) biomarkers impedes absolute discrimination in the differential diagnostic context.MethodsWe established the clinical parameters for prion disease diagnosis for the quantification of CSF α‐synuclein in patients with sporadic (n = 234) and genetic (n = 56) prion diseases, in cases with cognitive impairment/dementia or neurodegenerative disease (n= 278), and in the neurologic control group (n= 111).ResultsAn optimal cutoff value of 680 pg/mL α‐synuclein results in 94% sensitivity and 96% specificity when diagnosing sporadic Creutzfeldt‐Jakob disease (CJD). Genetic CJD cases showed increased CSF α‐synuclein values. No increased α‐synuclein levels were detected in non‐CJD cases with rapid progression course.DiscussionDetection of α‐synuclein in the CSF of patients with suspected CJD is a valuable diagnostic test reaching almost full discrimination from non‐prion disease cases. These data highlight the utility of CSF α‐synuclein quantification in front of classical CSF biomarkers in clinical routine.
A real‐world impact of cost‐effectiveness of pegylated interferon/ribavarin regimens on treatment‐naïve chronic hepatitis C patients in Taiwan
Authors: Tsai Pei‐Chien , Liu Ta‐Wei , Hsieh Meng‐Hsuan , Yeh Ming‐Lun , Liang Po‐Cheng , Lin Yi‐Hung , Huang Ching‐I , Huang Chung‐Feng , Hsieh Ming‐Yen , Hou Nai‐Jen , Lin Zu‐Yau , Chen Shinn‐Cherng , Huang Jee‐Fu , Dai Chia‐Yen , Chuang Wan‐Long , Yu Ming‐Lung 
Published: November 2016

AbstractTreatments with pegylated interferon/ribavirin (PEG‐IFN/RBV) has been standard‐of‐care in patients with chronic hepatitis C virus (HCV) (CHC) infection and reimbursed in Taiwan. However, the actual cost‐effectiveness remains unclear. We aimed to evaluate a real‐world cost‐effectiveness for CHC patients treated with PEG‐IFN/RBV by using a clinical cohort with linkage to the National Health Insurance Research Database of Taiwan. The total and itemized medical‐care expenses of outpatient visits of 117 treatment‐naïve CHC patients with linkage to the two million sampling of the National Health Insurance Research Database were collected. Four components of costs were assessed, including antiviral agents, nonantiviral agents, laboratory testing and consultation costs. The cost per sustained virological response (SVR) achieved was calculated to evaluate the cost‐effectiveness. The average cost per treatment in 117 naïve Taiwanese CHC patients was $4620. With an overall SVR rate of 78.6%, the average cost per SVR was $5878. The average medical‐care cost per treatment for 52 Genotype 1 (G1) patients was $5133, including $4420 for antivirals, $380 for nonantivirals, $302 for laboratory, and $78 for consultation, compared to $4209, $3635, $317, $233, and $56 for 65 Genotype 2 (G2) patients. With an SVR rate at 67.3% for G1 and 87.7% for G2 patients, the cost per SVR achieved was significantly higher in G1 patients than those in G2 patients ($7627 vs. $4799, p = 0.001). In the current study, we provided the real‐world cost‐effectiveness of PEG‐IFN/RBV for treatment‐naïve CHC patients. The genotype‐specific cost‐effectiveness could enhance decision‐making for policy‐makers in the coming era of directly acting antiviral therapy.
Domino in domino dominorum: Bede and John of Beverley
Authors: Biggs Frederick M. 
Published: November 2016

AbstractThe distinctive phrase, domino in domino dominorum, shared by the salutations in the prefatory letter of Bede's revised metrical Vita Cuthberti and in the letter sent by Hwaetbert with his former abbot Ceolfrith to Rome, reflects an unexpected historical connection among Bede's revision, Ceolfrith's departure and, more tentatively, the abdication of John of Beverley of the bishopric of York. While only Ceolfrith's journey has been dated to 716, I argue that Bede was revising his poem in anticipation of this event, but under the false assumption that it would be John of Beverley who would lead the party. The salutation, drawn from one of Augustine of Hippo's letters, supports this claim by identifying, after the opening phrase that would be appropriate for a bishop, John as a priest, a playful conjunction of terms used by Bede to call attention to the bishop of York's changing status. This opening, then, was in Bede's mind when the need for a letter from Hwaetbert to Pope Gregory II arose. Bede's revision and, probably, some discussion of John's retirement can be dated to 716.
The Exeter Book Riddles: authorship and transmission
Authors: Orton Peter 
Published: November 2016

AbstractThe Exeter Book Riddles are anonymous, and the generally formulaic character of all Old English verse discourages attempts to establish unity or diversity of authorship for them; but correlations between the sequence of Riddles in the manuscript and the recurrence from poem to poem of aspects of form, content (including solutions), presentation and style sometimes suggest common authorship for particular runs of texts, or reveal shaping episodes in the collection's transmission. Investigation along these lines throws up clear differences between the two main blocks of Riddles (1–59 and 61–95), and evidence emerges that the composition of many (at least) of Riddles 61–95 was influenced by a reading of Riddles 1–59.
Ælfric's apostles
Authors: Magennis Hugh 
Published: November 2016

AbstractNew Testament writings give a powerful sense of the humanness and fallibility of Christ's apostles, and a sense of their imperfection is also apparent in the non-canonical acts which report their missionary work and martyrdoms. Ælfric, drawing extensively on this biblical and extra-biblical material, adopts two distinct approaches in his treatment of the apostles, depending on whether he is writing hagiographically or exegetically. In neither approach does he present the apostles as imperfect or fallible, even where they appear so in the sources he is working with. The present article examines Ælfric's manoeuvres in rewriting the apostles as idealized and exemplary figures, focusing in particular on his treatment of Thomas, Peter and Paul in his homilies. In the case of Peter, Ælfric's approach is contrasted tellingly with that of the poet of The Heliand, who stresses the saint's powerful emotions and the personal nature of his relationship to Christ. The article demonstrates Ælfric's anxiety not to undermine the apostles in any way: bringing these great saints to life as struggling human beings is certainly not part of his agenda as religious teacher.
Explaining Anglo-Saxon military efficiency: the landscape of mobilization
Authors: Baker John , Brookes Stuart 
Published: November 2016

AbstractThe importance of warfare in Anglo-Saxon England is widely accepted, but the processes by which armies were put in the field are only partially understood, with most discussion focusing on the economic logistics rather than the spatial practicalities of mobilization. Yet such a system underpinned recorded military actions and must have evolved in response to changing military organization in the late Anglo-Saxon period. Through an assessment of documentary references to sites of muster, and by using a multidisciplinary landscape-focused approach, this article examines possible traces of that system – especially those preserved in place-names – and relates them to later Anglo-Saxon administrative geography.
Affective piety and the practice of penance in late-eleventh-century Worcester: the address to the penitent in Oxford, Bodleian Library, Junius 121
Authors: Forbes Helen Foxhall 
Published: November 2016

AbstractOxford, Bodleian Library, Junius 121, a manuscript written in Worcester in the early years of the episcopate of St Wulfstan (1062–95), contains a unique, untitled, anonymous text which has previously been interpreted as a Lenten homily. This article argues that this text is not a homily, but must be understood in the context of the penitential material surrounding it in Junius 121, for which it was probably specifically composed. The text has not attracted much attention, but it is an important early and vernacular witness to the developing tradition of affective writing which became prominent during the latter part of the eleventh century. In addition, the text itself and its placing in its manuscript context reveal the careful, deliberate decisions which Junius 121's compiler made about his material: by reusing earlier texts alongside newly composed English material, he provided practical pastoral and penitential materials for use in late-eleventh-century Worcester.
Psychiatric Disorders and Personality Styles in Mothers of Female Adolescent Patients with Eating Disorders
Authors: Rost Silke , Kappel Viola , Salbach Harriet , Schneider Nora , Pfeiffer Ernst , Lehmkuhl Ulrike , Winter Sibylle , Sarrar Lea 
Published: November 2016

Abstract. Objective: To provide further insight into the presently poorly understood role of familial psychopathology in the development of eating disorders (ED). Method: The present study assesses psychiatric and personality disorders listed on Axis I and II of the DSM-IV in 27 mothers of adolescent patients with anorexia (AN mothers) and 14 bulimia nervosa (BN mothers) as well as 22 mentally healthy girls (CG mothers) on a categorical level. Furthermore, we conducted a dimensional diagnostic regarding personality styles and personality traits. Results: AN and BN mothers showed increased rates of Axis I disorders, especially affective, substance use, and anxiety disorders. Differences on Axis II did not reach statistical significance. However, BN mothers showed higher occurrences of paranoid, negativistic, and schizotypal personality styles compared to the other groups. BN mothers further showed higher occurrences than CG mothers of the personality traits excitability, aggressiveness, physical complaints, openness, and emotionality. AN mothers differed significantly from CG mothers on the scale demands. Conclusions: Increased occurrence of psychopathology on both categorical and dimensional levels in mothers of patients with AN and BN supports the assumption of a familial accumulation of psychopathology in ED. Longitudinal studies and genetic analyses should clarify a possible cause-effect relationship and interactions between familial dynamics and adolescent ED. Keywords: eating disorders, adolescent patients, mothers, psychiatric disorders, personality styles.