bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal dysfunction and chronic kidney disease in ischemic stroke and transient ischemic attack: A population-based study
Authors: Hayden Derek , McCarthy Christine , Akijian Layan , Callaly Elizabeth , Ní Chróinín Danielle , Horgan Gillian , Kyne Lorraine , Duggan Joseph , Dolan Eamon , O’ Rourke Killian , Williams David , Murphy Sean , O’Meara Yvonne , Kelly Peter J 
Published: June 2017

Background and purpose The prevalence of chronic kidney disease (estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m2 for ≥3 months, chronic kidney disease (CKD)) in ischemic stroke and transient ischemic attack (TIA) is unknown, as estimates have been based on single-point estimates of renal function. Studies investigating the effect of renal dysfunction (eGFR < 60 mL/min per 1.73 m2, renal dysfunction) on post-stroke outcomes are limited to hospitalized cohorts and have provided conflicting results. Methods We investigated rates, determinants and outcomes of renal dysfunction in ischemic stroke and TIA in the North Dublin Population Stroke Study. We also investigate the persistence of renal dysfunction in 90-day survivors to determine the prevalence of CKD. Ascertainment included hot and cold pursuit using multiple overlapping sources. Survival analysis was performed using Kaplan–Meier survival curves and Cox proportional hazards modeling. Results In 547 patients (ischemic stroke in 76.4%, TIA in 23.6%), the mean eGFR at presentation was 63.7 mL/min/1.73 m2 (SD 22.1). Renal dysfunction was observed in 44.6% (244/547). Among 90-day survivors, 31.2% (139/446) met criteria for CKD. After adjusting for age and stroke severity, eGFR < 45 mL/min/1.73 m2 (hazard ratio 2.53, p = 0.01) independently predicted 28-day fatality but not at two years. Poor post-stroke functional outcome (Modified Rankin Scale 3–5) at two years was more common in those with renal dysfunction (52.5% vs. 20.6%, p < 0.001). After adjusting for age, stroke severity and pre-stroke disability, renal dysfunction (OR 2.17, p = 0.04) predicted poor functional outcome. Conclusion Renal dysfunction and CKD are common in ischemic stroke and TIA. Renal dysfunction is associated with considerable post-stroke morbidity and mortality. Further studies are needed to investigate if modifiable mechanisms underlie these associations.
Factors Affecting the Outcomes of Arthroscopically Repaired Traumatic Vertical Longitudinal Medial Meniscal Tears
Authors: Uzun Erdal , Misir Abdulhamit , Kizkapan Turan Bilge , Ozcamdalli Mustafa , Akkurt Soner , Guney Ahmet 
Published: June 2017

Background: Although numerous studies have assessed arthroscopic medial meniscal repairs, few studies have focused on factors affecting outcomes of vertical longitudinal and bucket-handle repairs. Purpose: To evaluate the factors affecting clinical outcomes of arthroscopically repaired traumatic vertical longitudinal and bucket-handle medial meniscal tears. Study Design: Case series; Level of evidence, 4. Methods: A total of 223 patients underwent arthroscopic repair for medial meniscal tears between 2007 and 2012; 140 patients had isolated tears or concurrent anterior cruciate ligament (ACL) reconstruction, and 80 patients (76 men, 4 women; mean age, 29.1 years; range, 18-49 years) had vertical longitudinal tears and were included in the study. Pre- and postoperative functional status was assessed using physical examinations with Lysholm and International Knee Documentation Committee (IKDC) scores. Barrett criteria were used for clinical assessment of meniscal healing, and magnetic resonance imaging (MRI) was used as the radiologic assessment method. The effects of tear location, length, chronicity, and type; suturing technique; concurrent ACL reconstruction; and patient age, sex, and smoking habits were also investigated. Results: The mean follow-up period was 51.2 ± 9.4 months (range, 34-85 months). The mean Lysholm and IKDC scores improved at final follow-up (both Ps <.001). According to clinical scores, Barrett criteria, and MRI, failure was noted in 12 patients (15%). There were no significant differences in age, tear length, tear type, concurrent ACL rupture, suturing technique, or location of the meniscal repair between the success and failure groups. Failure rates were higher for red-white zone tears than for red-red zone tears (10/30, 33.3% vs 2/50, 4%; P = .004). Tear chronicity significantly affected failure rates. Early repairs had higher healing rates than late repairs (100% vs 73.4%; P = .008). Failure rates were higher for smokers than for nonsmokers (9/24, 37.5% vs 3/56, 5.3%; P = .008). Conclusion: Peripheral tears and early repairs have better outcomes and patient satisfaction. Smoking adversely affects meniscal healing.
Oxynatromicrolite,
(Na,Ca,U)2Ta2O6(O,F), a new member of
the pyrochlore supergroup from Guanpo, Henan Province, China
Authors: Guang Fan , Xiangkun Ge , Guowu Li , Apeng Yu , Ganfu Shen 
Published: June 2017

AbstractA new mineral species of the pyrochlore supergroup, oxynatromicrolite
(IMA2013-063), (Na,Ca,U)2Ta2O6O, was found
in the No. 309 rare-metal granitic pegmatite vein, Guanpo, Lushi county,
Henan Province, China, which is characterized by tantalum at theB site and
oxygen at the Y site and is Na dominant at the A site. The mineral occurs as
strongly metamict, and mostly euhedral octahedral crystals up to 0.05–0.20
mm across. The measured density of an unheated sample is 6.580(4) g
cm–3, and the calculatedone is 6.506 g cm–3.
Optically, the mineral is isotropic, with an index of refraction 1.999(5)
and a reflectance of 11.88% (470 nm). When heated to 1000°C for 4 hours in
N2, the mineral recrystallizes in the cubic system, with space
group Fd3mand with unit-cell parameters
similar those of other pyrochlore supergroup species: a =
10.420(6) Å, V = 1131.4(2) Å3. Electron
microprobe analyses revealed the following composition of the mineral (in
wt.%): Na2O 5.41, CaO 4.56, UO214.60,
La2O3 0.16, Ce2O3 0.11,
Nd2O3 0.13, PbO 0.62, Ta2O5
61.52, Nb2O5 8.21, Sb2O5 0.23,
TiO2 0.05, SiO2 0.56, SnO2 0.29, F1.04,
H2O 1.50 (calculated to correspond to 0.47 H2O pfu), F≡O
–0.44, sum = 98.53%, which corresponds to the empirical formula
(Na0.99Ca0.46U0.31Pb0.02La0.01H2O0.21)∑2.00(Ta1.58Nb0.35Si0.05Sn0.01Sb0.01)∑2.00O6
(O0.43F0.31H2O0.26)∑1.00,
represented by the simplified formula
(Na,Ca,U)2(Ta,Nb)2O6(O,F).Oxynatromicrolite
crystallized during the late-stage of formation for the No. 309 pegmatite
dyke and is associated with quartz, albite, potassium feldspar, muscovite,
kaolinite, tantalite-Mn, stibiotantalite, pollucite, spodumene,
montebrasite, Hf-rich zircon, a red tourmaline,
polylithionite,trilithionite, luanshiweiite-2M1 (IMA2011-102) and a hydrated derivative of
oxynatromicrolite.
Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome
Authors: Vavassori Stefano , Galson Jacob D. , Trück Johannes , van den Berg Anke , Tamminga Rienk Y. J. , Magerus-Chatinet Aude , Pellé Olivier , Camenisch Gross Ulrike , Marques Maggio Ewerton , Prader Seraina , Opitz Lennart , Nüesch Ursina , Mauracher Andrea , Volkmer Benjamin , Speer Oliver , Suda Luzia , Röthlisberger Benno , Zimmermann Dieter Robert , Müller Rouven , Diepstra Arjan , Visser Lydia , Haralambieva Eugenia , Neven Bénédicte , Rieux-Laucat Frédéric , Pachlopnik Schmid Jana 
Published: June 2017

Key PointsFAS-dependent apoptosis in Vδ1 T cells makes the latter possible culprits for the lymphadenopathy observed in patients with FAS mutations. Rapamycin and methylprednisolone resistance should prompt clinicians to look for Vδ1 T cell proliferation in ALPS-FAS patients.
RETRACTED ARTICLE: Role of inhibitors of serine peptidases in protecting Leishmania donovani against the hydrolytic peptidases of sand fly midgut
Authors: Verma Sudha , Das Sushmita , Mandal Abhishek , Ansari Md Yousuf , Kumari Sujata , Mansuri Rani , Kumar Ajay , Singh Ruby , Saini Savita , Abhishek Kumar , Kumar Vijay , Sahoo Ganesh Chandra , Das Pradeep 
Published: June 2017

Abstract
Background
In vector-borne diseases such as leishmaniasis, the sand fly midgut is considered to be an important site for vector-parasite interaction. Digestive enzymes including serine peptidases such as trypsin and chymotrypsin, which are secreted in the midgut are one of the obstacles for Leishmania in establishing a successful infection. The presence of some natural inhibitors of serine peptidases (ISPs) has recently been reported in Leishmania. In the present study, we deciphered the role of these ISPs in the survival of Leishmania donovani in the hostile sand fly midgut environment.

Methods
In silico and co-immunoprecipitation studies were performed to observe the interaction of L. donovani ISPs with trypsin and chymotrypsin. Zymography and in vitro enzyme assays were carried out to observe the inhibitory effect of purified recombinant ISPs of L. donovani (rLdISPs) on trypsin, chymotrypsin and the sand fly midgut peptidases. The expression of ISPs in the amastigote to promastigote transition stages were studied by semi-quantitative RT-PCR and Western blot. The role of LdISP on the survival of ISP overexpressed (OE) and ISP knocked down (KD) Leishmania parasites inside the sand fly gut was investigated by in vitro and in vivo cell viability assays.

Results
We identified two ecotin-like genes in L. donovani, LdISP1 and LdISP2. In silico and co-immunoprecipitation results clearly suggest a strong interaction of LdISP molecules with trypsin and chymotrypsin. Zymography and in vitro enzyme assay confirmed the inhibitory effect of rLdISP on trypsin, chymotrypsin and the sand fly midgut peptidases. The expression of LdISP2 was found to be strongly associated with the amastigote to promastigote phase transition. The activities of the digestive enzymes were found to be significantly reduced in the infected sand flies when compared to uninfected. To our knowledge, our study is the first report showing the possible reduction of chymotrypsin activity in L. donovani infected sand flies compared to uninfected. Interestingly, during the early transition stage, substantial killing was observed in ISP2 knocked down (ISP2KD) parasites compared to wild type (WT), whereas ISP1 knocked down (ISP1KD) parasites remained viable. Therefore, our study clearly indicates that LdISP2 is a more effective inhibitor of serine peptidases than LdISP1.

Conclusion
Our results suggest that the lack of ISP2 is detrimental to the parasites during the early transition from amastigotes to promastigotes. Moreover, the results of the present study demonstrated for the first time that LdISP2 has an important role in the inhibition of peptidases and promoting L. donovani survival inside the Phlebotomus argentipes midgut.
Rheumatoid arthritis and psoriatic arthritis synovial fluids stimulate prolactin production by macrophages
Authors: Tang Man Wai , Garcia Samuel , Fernandez Beatriz Malvar , Gerlag Danielle M , Tak Paul-Peter , Reedquist Kris A 
Published: June 2017

Abstract
Prolactin (PRL) is a neuroendocrine hormone that can promote inflammation. We examined the synovial tissue and fluid levels of PRL in patients with inflammatory arthritis, PRL expression in differentiated Mϕs from patients with arthritis and from healthy donors, and the effects of different stimuli on PRL production by Mϕs. PRL levels were measured in paired synovial fluid (SF) and peripheral blood of patients with rheumatoid arthritis (RA, n = 19), psoriatic arthritis (PsA, n = 11), and gout (n = 11). Synovial-tissue PRL mRNA expression was measured by quantitative PCR in patients with RA (n = 25), PsA (n = 11), and gout (n = 12) and in Mϕs differentiated in SF of patients with RA, PsA, other subtypes of spondyloarthritis (SpA), and gout. Synovial-tissue PRL mRNA expression correlated significantly with clinical disease parameters in patients with RA and PsA, including erythrocyte sedimentation rate (ESR, r = 0.424; P = 0.049) and disease activity score evaluated in 28 joints (DAS28, r = 0.729; P = 0.017). Synovial-tissue PRL expression was similar in RA, PsA, and gout. PRL mRNA expression was detected in monocyte-derived Mϕs from patients with RA and was significantly higher (P ≤ 0.01) in Mϕs differentiated in pooled SF from patients with RA and PsA compared with SpA or gout. PRL production by Mϕ differentiation in the SF from patients with RA was not further regulated by stimulation with CD40L, IgG, LPS, or TNF. PRL is produced locally in the synovium of patients with inflammatory arthritis. The production of PRL by Mϕs was increased by unknown components of RA and PsA SF, where it could contribute to disease progression.
Staff experiences and perceptions of working with in-patients who are suicidal: qualitative analysis
Authors: Awenat Yvonne , Peters Sarah , Shaw-Nunez Emma , Gooding Patricia , Pratt Daniel , Haddock Gillian 
Published: June 2017

BackgroundSuicidal behaviour is frequent in psychiatric in-patients and much staff time and resources are devoted to assessing and managing suicide risk. However, little is known about staff experiences of working with in-patients who are suicidal.AimsTo investigate staff experiences of working with in-patients who are suicidal.MethodQualitative study guided by thematic analysis of semi-structured interviews with mental health staff with experience of psychiatric in-patient care.ResultsTwenty Staff participated. All had encountered in-patient suicide deaths or attempts. Three key themes were identified: (a) experiences of suicidality, (b) conceptualising suicidality and (c) talking about suicide.ConclusionsSuicidal behaviour in psychiatric wards has a large impact on staff feelings, practice and behaviour. Staff felt inadequately equipped to deal with such behaviours, with detrimental consequences for patients and themselves. Organisational support is lacking. Training and support should extend beyond risk assessment to improving staff skills in developing therapeutic interactions with in-patients who are suicidal.
Percutaneous cement augmentation for osteoporotic vertebral fractures
Authors: Sebaaly Amer , Rizkallah Maroun , Bachour Falah , Atallah Firas , Moreau Pierre Emmanuel , Maalouf Ghassan 
Published: June 2017

Thoracolumbar vertebral fracture incidents usually occur secondary to a high velocity trauma in young patients and to minor trauma or spontaneously in older people. Osteoporotic vertebral fractures are the most common osteoporotic fractures and affect one-fifth of the osteoporotic population. Percutaneous fixation by ‘vertebroplasty’ is a tempting alternative for open surgical management of these fractures. Despite discouraging initial results of early trials for vertebroplasty, cement augmentation proved its superiority for the treatment of symptomatic osteoporotic vertebral fracture when compared with optimal medical treatment. Early intervention is also gaining ground recently. Kyphoplasty has the advantage over vertebroplasty of reducing kyphosis and cement leak. Stentoplasty, a new variant of cement augmentation, is also showing promising outcomes. In this review, we describe the additional techniques of cement augmentation, stressing the important aspects for success, and recommend a thorough evaluation of thoracolumbar fractures in osteoporotic patients to select eligible patients that will benefit the most from percutaneous augmentation. A detailed treatment algorithm is then proposed. Cite this article: EFORT Open Rev 2017;2:293–299. DOI: 10.1302/2058-5241.2.160057
Effect of Different Mordants on Cotton Cloth Dyed with Aspergillus and Penicillium Dyes
Authors: Suciatmih Suciatmih , Hidayat Iman 
Published: June 2017

Natural dyes are an important alternative to potentially harmful synthetic dyes. This research was conducted using three kinds of Aspergillus dyes and six kinds of Penicillium dyes. In this study, Aspergillus and Penicillium were grown in mineral salts glucose medium. Premordanting technique was followed using different mordants, namely alum, CaCO3, CuSO4 5H2O, FeSO4 7H2O, K2Cr2O7 and MnSO4 H2O on cotton cloth. The colour of filtrate and range of colours developed on dyed materials were measured by RHS colour chart. The results indicated that the colour of dyed cloth was influenced by the addition of mordants, andÂ different shades were obtained from the same dye filtrate using different mordants. FeSO4 7H2O was found as the most influential mordant. The present study shows a new source of fungal dyes, which can be used as an alternative for dyeing cloth.
Projekcja ortograficznych form wewnątrzwyrazowych grup spółgłoskowych na transkrypcję fonologiczną na potrzeby systemu dzielenia na sylaby wyrazów języka polskiego
Authors: Śledziński Daniel 
Published: June 2017

W niniejszym artykule omówiono moduł, który jest częścią rozwijanego systemu dzielenia na sylaby dla języka polskiego. Zadanie tego modułu polega na odwzorowaniu wewnątrzwyrazowych grup spółgłoskowych zapisanych w formie ortograficznej na zapis w transkrypcji fonologicznej. Odwzorowanie jest bardzo precyzyjne – poszczególne litery zapisu ortograficznego wewnątrzwyrazowych grup spółgłoskowych są przypisane do poszczególnych fonemów. Podstawowy cel omawianego modułu związany jest z potrzebą stosowania zasad fonologicznych (zasady sonorności oraz zasady maksymalnego nagłosu) w odniesieniu do wyrazów ortograficznych. Te zasady bazują na fonologicznej skali sonorności, która przypisuje do dźwięków mowy abstrakcyjne wartości liczbowe. Te wartości odzwierciedlają cechy fonetyczne właściwe dla poszczególnych dźwięków mowy – przede wszystkim stopień rozwarcia narządów artykulacyjnych. W języku polskim występują złożone relacje między płaszczyzną ortograficzną i płaszczyzną fonologiczną. Dlatego przypisywanie wartości sonorności bezpośrednio do liter ortograficznych nie jest możliwe.
European Public Sector Accounting Standards (EPSAS)
Authors: Makaronidis Alexandre 
Published: June 2017

Abstract
This article represents solely the views of its author. It is based on a transcript of a speech delivered at the international workshop on “Which accounting regulation for Europe’s economy and society?” organised under the auspices of the European Parliament in Strasbourg, on 20 May 2015, in tribute to Mr Jérôme Haas (1963–2014), first chairman of the Accounting Standards Authority of France (ANC).
Neutrophil gelatinase-associated lipocalin as a risk marker in cardiovascular disease
Authors: Sivalingam Zenthuja , Larsen Sanne Bøjet , Grove Erik Lerkevang , Hvas Anne-Mette , Kristensen Steen Dalby , Magnusson Nils Erik 
Published: June 2017

Abstract
Neutrophil gelatinase-associated lipocalin (NGAL) is a promising diagnostic biomarker of early acute kidney injury. Increasing evidence suggests that NGAL may also be involved in inflammatory processes in cardiovascular disease. NGAL modulates the enzymatic activity of matrix metalloproteinase-9 (MMP-9), which is an important mediator of plaque instability in atherosclerosis. The complex formation between NGAL and MMP-9 therefore suggests that NGAL might play a role in progression of atherothrombotic disease. This review summarises current data on NGAL in atherosclerosis, acute myocardial infarction, and heart failure.
Towards a dynamic behavioral profile: A diachronic study of polysemous sentir in Spanish
Authors: Jansegers Marlies , Gries Stefan Th. 
Published: June 2017

AbstractThis study examines the diachronic evolution of the polysemy of the Spanish verbsentir(‘to feel’) by means of a corpus-based dynamic behavioral profile (BP) analysis. Methodologically, it presents the first application of the BP approach to historical data and proposes some methodological innovations not only within the current body of research in historical semantics but also with regard to previous applications of the BP approach. First, whereas the majority of existing studies in quantitative historical semantics are largely based on observed frequencies or percentages of collocational co-occurrence, our study leverages more complex historical data that are based on the similarities of vectors. Second, this study also provides an extension of the methodological apparatus of the BP approach by complementing the traditional hierarchical agglomerative cluster analysis (HAC) with a dynamic BP approach derived from multidimensional scaling maps (MDS). Theoretically, this methodology contributes to a comprehensive perspective on the process of Constructionalization and the nature of networks, which is illustrated on the basis of the development of the Discourse Marker (DM)lo siento(‘I’m sorry’).
An exponential-related function for decision-making in engineering and management
Authors: Aikhuele Daniel O. , Turan Faiz Mohd 
Published: June 2017

AbstractAn intuitionistic fuzzy TOPSIS model, which is based on an exponential-related function (IF-TOPSIS) and a fuzzy entropy method, has been proposed in this study. The exponential-related function, which represents the aggregated effect of positive and negative evaluations in the performance ratings of the alternatives, based on the intuitionistic fuzzy set (IFS) data. Serves, as a computational tool for measuring the separation distance of decision alternatives from the intuitionistic fuzzy positive and negative ideal solution to determine the relative closeness coefficient. The main advantage of this new approach is that (1) it uses a subjective and objective based approach for the computation of the criteria weight and (2) its simplicity both in its concept and computational procedures. The proposed method has successfully been implemented for the evaluation of some engineering designs related problems including the selection of a preferred floppy disk from a group of design alternatives, the selection of the best concept design for a new air-conditions system and finally, the selection of a preferred mouse from a group of alternatives as a reference for a new design. Also, for each of the three case studies, the method has been compared with some similar computational approaches.
Innate immunity orchestrates adipose tissue homeostasis
Authors: Lin Yi-Wei , Wei Li-Na 
Published: June 2017

Abstract
Obesity is strongly associated with multiple diseases including insulin resistance, type 2 diabetes, cardiovascular diseases, fatty liver disease, neurodegenerative diseases and cancers, etc. Adipose tissue (AT), mainly brown AT (BAT) and white AT (WAT), is an important metabolic and endocrine organ that maintains whole-body homeostasis. BAT contributes to non-shivering thermogenesis in a cold environment; WAT stores energy and produces adipokines that fine-tune metabolic and inflammatory responses. Obesity is often characterized by over-expansion and inflammation of WAT where inflammatory cells/mediators are abundant, especially pro-inflammatory (M1) macrophages, resulting in chronic low-grade inflammation and leading to insulin resistance and metabolic complications. Macrophages constitute the major component of innate immunity and can be activated as a M1 or M2 (anti-inflammatory) phenotype in response to environmental stimuli. Polarized M1 macrophage causes AT inflammation, whereas polarized M2 macrophage promotes WAT remodeling into the BAT phenotype, also known as WAT browning/beiging, which enhances insulin sensitivity and metabolic health. This review will discuss the regulation of AT homeostasis in relation to innate immunity.