bluuebunny/crossref_metadata_2025_split huggingface dataset:
Same‐Day Repeatability and 28‐Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi‐Site Trial
Authors: Walkup Laura L. , Roach David J. , Plummer Joseph W. , Willmering Matthew M. , Zanette Brandon , Santyr Giles , Fain Sean B. , Rock Michael J. , Mata Jaime , Froh Deborah , Stanojevic Sanja , Cleveland Zackary I. , Ratjen Felix , Woods Jason C. 
Published: September 2024

BackgroundMRI with xenon‐129 gas (Xe MRI) can assess airflow obstruction and heterogeneity in lung diseases. Specifically, Xe MRI may represent a sensitive modality for future therapeutic trials of cystic fibrosis (CF) therapies. The reproducibility of Xe MRI has not yet been assessed in the context of a multi‐site study.PurposeTo determine the same‐day repeatability and 28‐day reproducibility of Xe MRI in children with CF.Study TypeFour‐center prospective, longitudinal.PopulationThirty‐eight children (18 females, 47%), median interquartile range (IQR) age 12 (9–14) years old, with mild CF (forced expiratory volume in 1 second (FEV1) ≥85% predicted).Field Strength/Sequence3‐T, two‐dimensional (2D) gradient‐echo (GRE) sequence.AssessmentXe MRI, FEV1, and nitrogen multiple‐breath wash‐out for lung‐clearance index (LCI2.5) were performed. To assess same‐day reproducibility, Xe MRI was performed twice within the first visit, and procedures were repeated at 28 days. Xe hypoventilation was quantified using ventilation‐defect percentage (VDP) and reader‐defect volume (RDV). For VDP, hypoventilated voxels from segmented images were identified using a threshold of <60% mean whole‐lung signal and expressed as a percentage of the lung volume. For RDV, hypoventilation was identified by two trained readers and expressed as a percentage.Statistical TestsInter‐site comparisons were conducted using Kruskal–Wallis nonparametric tests with Dunn's multiple‐comparisons tests. Differences for individuals were assessed using Wilcoxon matched‐pairs tests. Bland–Altman tests were used to evaluate same‐day repeatability, 28‐day reproducibility, and inter‐reader agreement. A P‐value ≤0.05 was considered significant.ResultsMedian FEV1 %‐predicted was 96.8% (86%–106%), and median LCI2.5 was 6.6 (6.3–7.4). Xe MRI had high same‐day reproducibility (mean VDP difference 0.12%, 95% limits of agreement [−3.2, 3.4]; mean RDV difference 0.42% [−2.5, 3.3]). At 28 days, 26/31 participants (84%) fell within the same‐day 95% limits of agreement.Data ConclusionXe MRI may offer excellent same‐day and short‐term reproducibility.Evidence Level2Technical EfficacyStage 2
Impact of Previous Abdominal Surgery and Timing of Peritoneal Metastases on Accuracy of Imaging in Predicting the Surgical PCI: A Report From the PRECINCT Study
Authors: Bhatt Aditi , Rousset Pascal , Moran Brendan J. , Kazi Mufaddal , Baratti Dario , Morris David , Labow Daniel , Sardi Armando , Sammartino Paolo , Glehen Olivier ,   PRECINCT Study Group
Published: September 2024

ABSTRACTBackground and AimIn this report from Phase 1 of the prospective, observational, PRECINCT (Pattern of peritoneal dissemination and REsponse to systemic Chemotherapy IN Common and uncommon peritoneal Tumours) study, a correlation was performed between the radiological PCI (peritoneal cancer index; rPCI) and surgical PCI (sPCI). The impact of timing of peritoneal malignancy (PM) and previous abdominal surgery was also studied.MethodsThe rPCI and sPCI were considered the ‘same’ if they differed by ≤ 3 points. The agreement was assessed using Bland–Altman analysis and the strength of the agreement was assessed using the concordance correlation coefficient (CCC). The extent of prior surgery was classified according to prior surgical score (PSS).ResultsIn 707 (79.4%) patients, rPCI and sPCI concurred in 280 (39.6%). In the Bland–Altman analysis, < 40% patients were in the ±3 PCI points limit of acceptable difference. The average difference between the two scores was 4.5 points (95% CI‐ −5.16 to −3.92). The CCC‐ was 0.59 for the whole cohort (‘moderate’ concordance) and was not influenced by imaging modality, timing of PM or PSS.ConclusionsThe rPCI underestimated sPCI by an average of 4.5 points. The role of peritoneal MRI in patients undergoing iterative procedures and the performance of imaging according to sites of recurrence need further evaluation.
Relationship of Surgical Approach With Financial Toxicity in Patients With Resected Lung Cancer
Authors: Deboever Nathaniel , Eisenberg Michael A. , Antonoff Mara B. , Hofstetter Wayne L. , Mehran Reza J. , Rice David C. , Roth Jack A. , Swisher Stephen G. , Vaporciyan Ara A. , Walsh Garrett L. , Rajaram Ravi 
Published: September 2024

ABSTRACTIntroductionMinimally invasive surgery (MIS) reduces lengths of stay, complications, and potentially perioperative hospital costs. However, the impact of MIS on financial toxicity (FT), defined as the costs resulting from oncologic care and their negative effects on quality of life, in patients with lung cancer is unknown. Our objective was to investigate the association between surgical approach and FT in this population.MethodsA single‐institution study was performed evaluating resected lung cancer patients (2016–2021). FT was assessed using the Comprehensive Score for Financial Toxicity (COST) questionnaire. The relationship between surgical approach (MIS vs. thoracotomy) and FT was evaluated using propensity score‐matched (PSM) regression analysis. A sensitivity analysis involving the entire cohort was also performed using an inverse probability‐weighted generalized linear model.ResultsAs reported previously, of 1477 patients surveyed, 463 responded (31.3%) with FT reported in 196 patients (42.3%). Resection was performed by thoracotomy in 53.3% (n = 247), and by MIS in the remainder (n = 216, 46.7%; video‐assisted thoracoscopic surgery [VATS] = 115; robotic‐assisted = 101). There was no difference in FT in patients who underwent VATS and robotic‐assisted surgery (p = 0.515). In the PSM analysis, MIS was not associated with FT (odds ratio [OR]: 0.980, 95% confidence interval [CI]: 0.628–1.533, p = 0.929). Similar results were found on sensitivity analysis (OR: 1.488, CI: 0.931–2.378, p = 0.096).ConclusionsCompared to MIS, thoracotomy was not associated with FT in patients with resected lung cancer. Though there are several benefits from MIS, it does not appear to be a meaningful strategy to alleviate FT in this population.
Classification of Gastric Neuroendocrine Tumors and Associations With Survival
Authors: Song Yun , Chen Eunise , Chiang Yi‐Ju , Yao James C. , Halperin Daniel M. , Chatterjee Deyali , Badgwell Brian D. 
Published: September 2024

ABSTRACTBackground and ObjectivesNot all gastric neuroendocrine tumors (GNETs) may be classified into one of the three described clinicopathologic subtypes. The purpose of this study was to better characterize GNET subtypes and associated outcomes.MethodsPatients treated for GNET at our institution (1995−2021) were identified. Pathologic specimens of tumors that could not be classified as type 1, 2, or 3 were further reviewed. GNETs were categorized as proton pump inhibitor (PPI)‐associated based on changes in the background gastric mucosa consistent with PPI use. Distant metastasis at presentation (DM) and disease‐specific survival (DSS) were evaluated.ResultsAmong 246 patients, there were 164 (67%) type 1, 5 (2%) type 2, 52 (21%) type 3, and 18 (7%) PPI‐associated GNETs. Seven (3%) tumors remained unclassified. DM was more frequent with type 3 GNETs (38%) than type 1 (1%), type 2 (20%), or PPI‐associated tumors (11%, p < 0.001). Ten‐year DSS rates were 100% for type 1, 53% (95% confidence interval [CI], 38%−75%) for type 3, and 80% (95% CI, 58%−100%) for PPI‐associated tumors (p < 0.001). GNET subtype, race, and DM were independently associated with DSS.ConclusionsPPI‐associated tumors may represent a distinct GNET subtype with intermediate outcomes. Other factors should also be considered in overall prognosis.
Monitoring Apoptosis and Myeloid Differentiation of Acridine Orange‐Mediated Sonodynamic Therapy‐Induced Human Promyelocytic Leukemia HL60 Cells
Authors: Caliskan Metin , Ilikci‐Sagkan Rahsan , Bayrak Gulsen , Ozlem‐Caliskan Sercin 
Published: September 2024

ObjectivesIn the treatment of acute myeloid leukemia (AML), conventional therapies can lead to severe side effects and drug resistance. There is a need for alternative treatments that do not cause treatment resistance and have minimal or no side effects. Sonodynamic therapy (SDT), due to its noninvasive, multiple repeatability, localized treatment feature and do not cause treatment resistance, emerges as an alternative treatment option. However, it has not received sufficient attention in the treatment of AML especially acute promyelocytic leukemia (APL). The aim of the study was to investigate the potential differentiation and antileukemic effects of acridine orange (AO)‐mediated SDT on HL60 cells.MethodsCell viability was determined by the 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) method in the control, ultrasound, AO concentrations, and ultrasound‐exposed AO concentrations groups. Transmission electron microscopy (TEM) was used to determine morphology, and flow cytometry was used to determine apoptosis, DNA cycle, cell volume, mitochondria membrane potential (Δψm), reactive oxygen species (ROS) production, and differentiation markers (CD11b and CD15) expressions. Additionally, toluidine blue staining for semithin sections was used to determine differentiation.ResultsThe cytotoxicity of AO‐mediated SDT on HL60 cells was significantly higher than other groups, and TEM images showed that it caused various morphological changes typical for apoptosis. Flow cytometry results showed the presence of early apoptosis, subG1 arrest, loss of Δψm, increase of intracellular ROS production, decreased cell volume, and increased expression of CD11b (1.3‐fold) antigen and CD15 (1.2‐fold) antigen.ConclusionData showed that AO‐mediated SDT significantly induced apoptosis in HL60 cells. Increased expression of CD11b and CD15 antigens and morphological findings demonstrated that AO‐mediated SDT contributes to granulocytic differentiation in HL60 cells. AO‐mediated SDT has potential as an alternative treatment of APL.
Significant systematic bias of alpha angles measured on MRI compared to various radiographic views in patients with femoroacetabular impingement syndrome
Authors: Triana Jairo , Shankar Dhruv S. , Moore Michael A. , Akpinar Berkcan , Vasavada Kinjal D. , Burke Christopher J. , Samim Mohammad M. , Youm Thomas 
Published: September 2024

AbstractPurposeThe aim of this study was to assess the inter‐rater reproducibility and inter‐method comparability of hip alpha angle measurements on magnetic resonance imaging (MRI)/magnetic resonance arthrography (MRA) and plain radiographs in patients with femoroacetabular impingement syndrome (FAIS).MethodsA cross‐sectional study of patients who were diagnosed with symptomatic FAIS underwent preoperative MRI/MRA with axial oblique and/or radial plane imaging and had preoperative radiographs with anterior‐posterior (AP), 45° Dunn and 90° Dunn views. Alpha angle measurements were performed independently by two musculoskeletal radiologists. Inter‐rater reproducibility and inter‐method comparability between MRI/MRA images and radiographic views were assessed using the intraclass correlation coefficient (ICC) with 95% confidence interval (CI).ResultsNinety‐seven patients were included of whom 93 (95.8%) received axial oblique plane images and 54 (55.6%) had radial plane MRI/MRA images. Inter‐rater reproducibility was excellent (ICC > 0.9) for all planes on MRI/MRA and radiographs. MRI/MRA axial oblique images had poor (ICC 0.39, 95% CI [0.09, 0.59]), moderate (ICC 0.57, 95% CI [0.18, 0.75]) and moderate (ICC 0.64, 95% CI [0.20, 0.81]) comparability with AP, 45° Dunn and 90° Dunn, respectively. MRI/MRA radial plane images had equivocal (0 included in all CIs) comparability with AP (ICC 0.66), 45° Dunn (ICC 0.35) and 90° Dunn (ICC 0.14) radiographs. On average, alpha angle measurements were significantly higher with radial images and lower with axial oblique images, when compared to all radiographic views (p < 0.05), except axial oblique versus 45° Dunn views, where angles measured on axial oblique were significantly larger.ConclusionAlpha angle measurements taken on axial oblique MRI/MRA images show moderate comparability to radiographic 45° Dunn and 90° Dunn views despite negative bias to measurements taken on radiographic AP and 45° Dunn view. Larger alpha angles were appreciated on MRI/MRA radial and axial oblique views compared to radiographic views supporting the inclusion of MRI/MRA alpha angle measurements to properly identify deformity.Level of EvidenceLevel II.
Combined PCL instabilities cannot be identified using posterior stress radiographs in external or internal rotation: A cadaveric study
Authors: Briese Thorben , Riemer Romy , Deichsel Adrian , Peez Christian , Herbst Elmar , Glasbrenner Johannes , Raschke Michael J. , Kittl Christoph 
Published: September 2024

AbstractPurposePosterior stress radiography is recommended to identify isolated or combined posterior cruciate ligament (PCL) deficiencies. The posterior drawer in internal (IR) or external rotation (ER) helps to differentiate between these combined instabilities. The purpose of this study was to evaluate posterior stress radiography (PSR) in isolated and combined PCL deficiency with IR and ER compared to PSR in neutral rotation (NR) for diagnosing combined PCL instabilities.MethodsSix paired fresh‐frozen human cadaveric legs (n = 12) were mounted in a Telos device for PSR. The tibia was rotated using an attached foot apparatus capable of rotating the foot 30° internally and externally. A posterior tibial load of 15 kp (147.1 N) was applied to the tibial tubercle at 90° knee flexion, and a lateral radiograph was obtained. This was repeated with the foot in 30° IR and ER. The PCL, posterolateral complex (PLC), and posteromedial complex (PMC) were sectioned in six knees, while the PMC was sectioned before the PLC in the other six knees. Posterior tibial displacement (PTD) was measured radiographically. Statistical analysis was performed using a two‐way ANOVA and a mixed model with Bonferroni correction, and the significance was set at p < 0.05. Furthermore, intra‐ and interobserver reliability was determined.ResultsCutting the PCL significantly increased the radiographic PTD by 9.8 ± 1.8 mm (side‐to‐side difference compared to the intact state of the knee, n = 12; p < 0.001). This further increased to 12.2 ± 2.3 mm (n = 6; p < 0.01) with an additional PLC deficiency and to 15.4 ± 3.4 mm (n = 6; p < 0.05) with an additional PMC deficiency. A combined PLC and PMC deficiency resulted in an increase of the PTD to 15.9 ± 4.5 mm (n = 12; p < 0.01). In the PCL/PLC deficient state, ER did not demonstrate a higher PTD, compared to the NR and IR posterior drawer. In the PCL/PMC deficient state in IR, PTD was 1.6 ± 0.7 mm (p < 0.01) higher compared to NR and 3.2 ± 1.9 mm (p < 0.05) higher compared to ER. We showed excellent intra‐ and interobserver reliability (0.987–0.997).ConclusionCombined PCL instabilities resulted in a significant increase in posterior tibial displacement in posterior stress radiographs. However, PSR in IR or ER was unable to differentiate between these combined instabilities. Based on our data, additional stress radiographs in rotation are unlikely to provide any diagnostic benefit in the clinical setting.Level of EvidenceThere is no level of evidence as this study was an experimental laboratory study.
Krüppel‐like factors family in health and disease
Authors: Xiang Tingwen , Yang Chuan , Deng Zihan , Sun Dong , Luo Fei , Chen Yueqi 
Published: September 2024

AbstractKrüppel‐like factors (KLFs) are a family of basic transcription factors with three conserved Cys2/His2 zinc finger domains located in their C‐terminal regions. It is acknowledged that KLFs exert complicated effects on cell proliferation, differentiation, survival, and responses to stimuli. Dysregulation of KLFs is associated with a range of diseases including cardiovascular disorders, metabolic diseases, autoimmune conditions, cancer, and neurodegenerative diseases. Their multidimensional roles in modulating critical pathways underscore the significance in both physiological and pathological contexts. Recent research also emphasizes their crucial involvement and complex interplay in the skeletal system. Despite the substantial progress in understanding KLFs and their roles in various cellular processes, several research gaps remain. Here, we elucidated the multifaceted capabilities of KLFs on body health and diseases via various compliable signaling pathways. The associations between KLFs and cellular energy metabolism and epigenetic modification during bone reconstruction have also been summarized. This review helps us better understand the coupling effects and their pivotal functions in multiple systems and detailed mechanisms of bone remodeling and develop potential therapeutic strategies for the clinical treatment of pathological diseases by targeting the KLF family.
Optimal reverse channel for end‐of‐life vehicle closed‐loop supply chains
Authors: Ding Junfei , Zhang Wen , Pu Xujin 
Published: September 2024

AbstractThis study examines a manufacturer selling directly to customers has three modes for acquiring end‐of‐life vehicles with a key component supplier: supplier‐collection, manufacturer‐collection, and third‐party‐collection modes. We find that the supplier, who is farther away from customers, is the optimal agent to be responsible for recovery activity. Following, we design a simple transfer price contract for the supplier‐collection mode such that the recovery rate achieves the centralized level. Subsequently, a fixed payment is proposed to compensate the supplier, thereby realizing Pareto improvement. Finally, we consider the supplier as the Stackelberg leader and find opposite results regarding optimal reverse channel structure.
Toward bridging gaps in patient navigation: A study on the adoption of artificial intelligence technologies
Authors: Chen Fenghao , Lan Tu , Liang Jie , Zhang Ronghui 
Published: September 2024

AbstractBackgroundPatient navigators, whose value has become increasingly apparent, still face significant challenges, including a lack of support, funding, and recognition. These challenges have been exacerbated in the wake of COVID‐19 pandemic.MethodsThis study explored the potential use of artificial intelligence (AI) in patient navigation. Data were collected through structured surveys and individual interviews with patient navigators from a variety of institutions and professional backgrounds. The data were analyzed to understand the current state of patient navigation, identify existing gaps, and suggest best practices for the future.ResultsThe findings showed that patient navigators (a) have diverse backgrounds and responsibilities, (b) lack technology support for their work, (c) are at risk for burnout, with the extent varying based on the level of technical support received, and (d) report significant overlap between current barriers and those that could potentially be addressed with AI‐driven technologies.ConclusionA novel intervention, that is enabled by AI and other technologies and tailored to individual needs, has the potential to reduce burnout, increase capacity, and help ensure the sustainability of patient navigation and other areas of healthcare. By addressing the specific needs of individual patients, this type of intervention could help improve the overall effectiveness of patient navigation and support the long‐term sustainability of the role.
An investigation into differential use of ocher in burials at Khok Phanom Di, Thailand
Authors: Paris Sarah Elizabeth 
Published: September 2024

AbstractOcher has been observed as a feature of burial traditions around the world, throughout history and prehistory. In Southeast Asia ocher first appears in Hòabìnhian burials; however, it is used discriminately, varying within and between sites. Understanding the selection process for individuals with pigmented burials has been difficult due to their limited number. The site of Khok Phanom Di, Thailand, dating from ~4000 to 3500 BP, reflects the variation of pigment use seen in earlier sites, with 82% of burials found to have ocher. The cemetery's uninterrupted use for ~500 years, the high number and standard of preservation of human remains, and nearly four decades of bioarcheological research have facilitated a detailed study of the use of pigment in relation to bioarcheological factors. This work examines the relationship between the presence or absence of ocher within a burial and chronology, age, sex, mobility, funerary behavior, and spatial organization to understand whether there was a relationship between selective use of ocher and these attributes. The results found a relationship between ocher use and burial chronology, grave type, grave goods, and age. Multivariate analysis demonstrates that age interacts with the other predictors of ocher. Burials without ocher are almost exclusively those of perinates, these were commonly small, shallow “scoop” burials without grave goods. The presence of ocher in ~38% of perinate burials illustrates the complexity of selective pigment use and demonstrates the need for further research.
Continuity and change in animal husbandry during the Later Iron Age of Britain
Authors: Bormetti Matteo , Albarella Umberto 
Published: September 2024

AbstractThe Later Iron Age in Britain was a transformative period: material culture, settlement patterns, technology, trade networks, and the structures of power changed, ultimately leading to the Roman invasion. This paper examines the significance of investigating animal economies in this period within the broader context of socio‐economic developments. It reviews the available evidence regarding animal economies in this period, integrates new osteometric analyses, and discusses diachronic changes using the Roman evidence on a comparative basis. The investigation shows a broad pattern of continuity of practice, with relatively uniform livestock types and management strategies until the very end of the Iron Age. This suggests that the trajectory of local farming practices was largely independent from Mediterranean developments. This study contributes to a deeper understanding of Iron Age societies and their response to external influences, while also informing future research directions in archaeology.