bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resurfacing Symptomatic Reading: Contrapuntal Memory and Postcolonial Method inThe Remains of the Day
Authors: Thakkar Sonali 
Published: February 2017

AbstractThis essay onThe Remains of the Dayand modes of reading takes as its starting point the novel’s historical setting of July 1956, which coincides with the beginning of the Suez crisis. Although the crisis never explicitly registers in the narrative, various moments of imperial affirmation and anxiety suggest that it may have the status of a symptom. I read with and against this supposition. In the essay’s first section, I show how the repression of imperial crisis in Stevens’s narrative is entangled with his memories of fascist appeasement and complicity. Prompted by the text’s pervasive and self-conscious interest in Freudian figures of memory—its untimeliness and displacements—the second part argues thatThe Remains of the Dayincorporates the symptom as an aesthetic and historical strategy in order to itself theorize a postcolonial symptomatology. The novel thus helps us complicate the proposition that symptomatic reading is something critics do to texts and suggests, in its allegory of symptomatic reading, the contours of a postcolonial interpretive method.
Differential Publics—Reading (in) the Postcolonial Novel
Authors: Boehmer Elleke 
Published: February 2017

AbstractThis essay discusses the activity of reading in three postcolonial novels from three different national contexts (Dangarembga in Zimbabwe, Kapur in India, and Adichie in Nigeria). The essay considers the scenes of focused, respectful, even canonical reading staged in these novels, alongside the more selective or eclectic “reading” and citation taking place at the level of the narration. On the basis of this contrast, it suggests that the postcolonial and transnational publics interpellated by the novels are sometimes different from the audiences or readers dramatized in the texts. It concludes by pointing to the particularly layered—at once deferential and exploratory—reading that is staged within, and by, the postcolonial novel. The essay is shaped by postcritical, cognitive, and hermeneutic approaches to narrative and reading drawn from Rita Felski, James Phelan, Dan Sperber, and Deirdre Wilson.
Livestock depredation by large predators and its implications for conservation and livelihoods in the Karakoram Mountains of Pakistan
Authors: Khan Muhammad Zafar , Khan Babar , Awan Muhammad Saeed , Begum Farida 
Published: February 2017

AbstractLivestock depredation has particular significance in pastoral societies across the Himalayas. The dynamics of depredation by the snow leopard Panthera uncia and wolf Canis lupus were investigated by means of household surveys in the Hushey Valley, in the Karakoram Mountains of Pakistan. During 2008–2012 90% of the households in the valley lost livestock to snow leopards and wolves, accounting for 0.8 animals per household per year. The cost of depredation per household was equivalent to PKR 9,853 (USD 101), or 10% of the mean annual cash income. The majority (41%) of predation incidents occurred in summer pastures, predominantly at night in open spaces. Of the total number of predation incidents, 60% were attributed to snow leopards and 37% to wolves; in 3% of cases the predator was unknown. As an immediate response to predation the majority of the local people (64%, n = 99) opted to report the case to their Village Conservation Committee for compensation and only 1% preferred to kill the predator; 32% did not respond to predation incidents. The perceived causes of predation were poor guarding (77%), reduction in wild prey (13%), and livestock being the favourite food of predators (10%). The most preferred strategies for predator management, according to the respondents, were enhanced guarding of livestock (72%), followed by increasing the availability of wild prey (18%), and lethal control (10%). Livestock depredation causing economic loss may lead to retaliatory killing of threatened predators. For carnivore conservation and livestock security in this area we recommend improved livestock guarding through collective hiring of skilled shepherds and the use of guard dogs.
Impact of childhood and adulthood psychological health on labour force participation and exit in later life
Authors: Clark C. , Smuk M. , Lain D. , Stansfeld S. A. , Carr E. , Head J. , Vickerstaff S. 
Published: February 2017

BackgroundAdulthood psychological health predicts labour force activity but few studies have examined childhood psychological health. We hypothesized that childhood psychological ill-health would be associated with labour force exit at 55 years.MethodData were from the 55-year follow-up of the National Child Development Study (n = 9137). Labour force participation and exit (unemployment, retirement, permanent sickness, homemaking/other) were self-reported at 55 years. Internalizing and externalizing problems in childhood (7, 11 and 16 years) and malaise in adulthood (23, 33, 42, 50 years) were assessed. Education, social class, periods of unemployment, partnership separations, number of children, and homemaking activity were measured throughout adulthood.ResultsChildhood internalizing and externalizing problems were associated with unemployment, permanent sickness and homemaking/other at 55 years, after adjustment for adulthood psychological health and education: one or two reports of internalizing was associated with increased risk for unemployment [relative risk (RR) 1.59, 95% confidence interval (CI) 1.12–2.25; RR 2.37, 95% CI 1.48–3.79] and permanent sickness (RR 1.32, 95% CI 1.00–1.74; RR, 1.48, 95% CI 1.00–2.17); three reports of externalizing was associated with increased risk for unemployment (RR 2.26, 95% CI 1.01–5.04), permanent sickness (RR 2.63, 95% CI 1.46–4.73) and homemaking/other (RR 1.95, 95% CI 1.00–3.78).ConclusionsPsychological ill-health across the lifecourse, including during childhood, reduces the likelihood of working in older age. Support for those with mental health problems at different life stages and for those with limited connections to the labour market, including homemakers, is an essential dimension of attempts to extend working lives.
The right to legal agency: domination, disability and the protections of Article 12 of the Convention on the Rights of Persons with Disabilities
Authors: Arstein-Kerslake Anna , Flynn Eilionóir 
Published: February 2017

AbstractArticle 12 of the Convention on the Rights of Persons with Disabilities has created a revolution in legal-capacity law reform. It protects the right to exercise legal agency for people with disabilities with more clarity than any prior human rights instrument. This paper explores what constitutes an exercise of legal agency and what exactly Article 12 protects. It proposes a definition of legal agency and applies it to the lived experience of cognitive disability. It also uses a republican theory of domination to argue that people with cognitive disabilities who are experiencing domination are forced to assert legal agency in even daily decision-making because of the high level of external regulation of their lives and the ever-present threat of others substituting their decision-making. It identifies Article 12 as a tool for protecting such exertions of legal agency and curtailing relationships of domination.
Recognising legal capacity: commentary and analysis of Article 12 CRPD
Authors: de Bhailís Clíona , Flynn Eilionóir 
Published: February 2017

AbstractThis paper aims to summarise the current understanding and literature around Article 12 of the Convention on the Rights of Persons with Disabilities (CRPD). It provides a brief history of the key terms associated with the right to equal recognition before the law and encompasses both academic writing in this area and General Comment No. 1 from the Committee on the Rights of Persons with Disabilities. The content is intended to provide readers of this Special Issue with a general understanding of developments surrounding Article 12 so they can fully engage with the other papers within this Special Issue and with the content of the Voices of Individuals: Collectively Exploring Self-determination (VOICES) project as a whole.
CRPD and transformative equality
Authors: Minkowitz Tina 
Published: February 2017

AbstractThis reflection responds primarily to the papers on legal agency and state intervention, with brief comments on the two other papers. The concept of transformative equality, developed in jurisprudence under the Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW), can promote a deeper understanding of the rights of persons with disabilities.1In particular, it is useful to address power relations between disabled and non-disabled persons not only with respect to family members and medical professionals, but also in the institutions of law and the state.
Prevalence and factors associated with depression and depression-related healthcare access in mothers of 9-month-old infants in the Republic of Ireland
Authors: Cruise S. M. , Layte R. , Stevenson M. , O'Reilly D. 
Published: February 2017

Aims.Untreated maternal depression during the postpartum period can have a profound impact on the short- and long-term psychological and physical well-being of children. There is, therefore, an imperative for increased understanding of the determinants of depression and depression-related healthcare access during this period.Methods.Respondents were 11 089 mothers of 9-month-old infants recruited to the Growing Up in Ireland study. Of this sample, 10 827 had complete data on all relevant variables. Respondents provided sociodemographic, socioeconomic and household information, and completed the Center for Epidemiologic Studies Depression Scale (CESD).Results.11.1% of mothers scored above the CESD threshold for depression. 10.0% of depressed mothers and 25.4% of depressed fathers had depressed partners. Among depressed mothers, 73.1% had not attended a healthcare professional for a mental health problem since the birth of the cohort infant. In the adjusted model, the likelihood of depression was highest in mothers who: had lower educational levels (odds ratio (OR) 1.26; 95% confidence intervals (CIs) 1.08, 1.46); were unemployed (OR 1.27; 95% CIs 1.10, 1.47); reported previous mental health problems (OR 6.55; 95% CIs 5.68, 7.56); reported that the cohort child was the result of an unintended pregnancy (OR 1.43; 95% CIs 1.22, 1.68), was preterm (OR 1.35; 95% CIs 1.07, 1.70), or had health/developmental problems (OR 1.20; 95% CIs 1.04, 1.39); had no partner in the household (OR 1.33; 95% CIs 1.04, 1.70) or were living with a depressed partner (OR 2.66; 95% CIs 1.97, 3.60); reported no family living nearby (OR 1.33; 95% CIs 1.16, 1.54); were in the lowest income group (OR 1.60; 95% CIs 1.21, 2.12). The primary determinant of not seeking treatment for depression was being of non-white ethnicity (OR 2.21; 95% CIs 1.18, 4.13).Conclusions.Results highlight the prevalence of maternal depression in the later postpartum period, particularly for lower socioeconomic groups, those with previous mental health problems, and those with limited social support. The large proportion of unmet need in depressed mothers, particularly among ethnic minority groups, emphasises the need for a greater awareness of postpartum mental health problems and increased efforts by healthcare professionals to ensure that mothers can access the required services.
Interacting Variables: September 11 and the Role of Ideas and Domestic Politics
Authors: Gourevitch Peter 
Published: February 2017

The events of September 11 can be taken as a good place to explore the interaction of variables in explaining events. We know that many variables are at play in most complex situations. Taking account of them all is impossible, and even investigating several is messy. One way to tackle this problem is to pay closer attention to the interaction of variables--not to look at all of them but to explore carefully where they intersect and to detect the mechanisms of their relationships.Many of the quarrels in our field arise out of a desire to assert aggressively the predominance of a particular, favored variable. Wearying of this sort of combat, some analysts have become more interested in examining the connections among variables, the ways in which one parameter acquires strength or signals causality because of its interaction with another. The events of September 11 show the values of this approach. It will surely involve some loss of parsimony, but it may lead to important insights and research programs. To pursue it, we need models of causality that work with interactions.
Molecular stratification of early breast cancer identifies drug targets to drive stratified medicine
Authors: Bayani Jane , Yao Cindy Q. , Quintayo Mary Anne , Yan Fu , Haider Syed , D’Costa Alister , Brookes Cassandra L. , van de Velde Cornelis J. H. , Hasenburg Annette , Kieback Dirk G. , Markopoulos Christos , Dirix Luc , Seynaeve Caroline , Rea Daniel , Boutros Paul C. , Bartlett John M. S. 
Published: February 2017

AbstractMany women with hormone receptor-positive early breast cancer can be managed effectively with endocrine therapies alone. However, additional systemic chemotherapy treatment is necessary for others. The clinical challenges in managing high-risk women are to identify existing and novel druggable targets, and to identify those who would benefit from these therapies. Therefore, we performed mRNA abundance analysis using the Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial pathology cohort to identify a signature of residual risk following endocrine therapy and pathways that are potentially druggable. A panel of genes compiled from academic and commercial multiparametric tests as well as genes of importance to breast cancer pathogenesis was used to profile 3825 patients. A signature of 95 genes, including nodal status, was validated to stratify endocrine-treated patients into high-risk and low-risk groups based on distant relapse-free survival (DRFS; Hazard Ratio = 5.05, 95% CI 3.53–7.22, p = 7.51 × 10−19). This risk signature was also found to perform better than current multiparametric tests. When the 95-gene prognostic signature was applied to all patients in the validation cohort, including patients who received adjuvant chemotherapy, the signature remained prognostic (HR = 4.76, 95% CI 3.61-6.28, p = 2.53× 10−28). Functional gene interaction analyses identified six significant modules representing pathways involved in cell cycle control, mitosis and receptor tyrosine signaling; containing a number of genes with existing targeted therapies for use in breast or other malignancies. Thus the identification of high-risk patients using this prognostic signature has the potential to also prioritize patients for treatment with these targeted therapies.
Cockroach protease allergen induces allergic airway inflammation via epithelial cell activation
Authors: Kale Sagar L. , Agrawal Komal , Gaur Shailendra Nath , Arora Naveen 
Published: February 2017

AbstractProtease allergens are known to enhance allergic inflammation but their exact role in initiation of allergic reactions at mucosal surfaces still remains elusive. This study was aimed at deciphering the role of serine protease activity of Per a 10, a major cockroach allergen in initiation of allergic inflammation at mucosal surfaces. We demonstrate that Per a 10 increases epithelial permeability by disruption of tight junction proteins, ZO-1 and occludin, and enhances the migration of Monocyte derived dendritic cell precursors towards epithelial layer as exhibited by trans-well studies. Per a 10 exposure also leads to secretion of IL-33, TSLP and intracellular Ca2+dependent increase in ATP levels. Further,in vivoexperiments revealed that Per a 10 administration in mice elevated allergic inflammatory parameters along with high levels of IL-33, TSLP, IL-1α and uric acid in the mice lungs. We next demonstrated that Per a 10 cleaves CD23 (low affinity IgE receptor) from the surface of PBMCs and purified B cells and CD25 (IL-2 receptor) from the surface of PBMCs and purified T cells in an activity dependent manner, which might favour Th2 responses. In conclusion, protease activity of Per a 10 plays a significant role in initiation of allergic airway inflammation at the mucosal surfaces.
A novel augmented reality system for displaying inferior alveolar nerve bundles in maxillofacial surgery
Authors: Zhu Ming , Liu Fei , Chai Gang , Pan Jun J. , Jiang Taoran , Lin Li , Xin Yu , Zhang Yan , Li Qingfeng 
Published: February 2017

AbstractAugmented reality systems can combine virtual images with a real environment to ensure accurate surgery with lower risk. This study aimed to develop a novel registration and tracking technique to establish a navigation system based on augmented reality for maxillofacial surgery. Specifically, a virtual image is reconstructed from CT data using 3D software. The real environment is tracked by the augmented reality (AR) software. The novel registration strategy that we created uses an occlusal splint compounded with a fiducial marker (OSM) to establish a relationship between the virtual image and the real object. After the fiducial marker is recognized, the virtual image is superimposed onto the real environment, forming the “integrated image” on semi-transparent glass. Via the registration process, the integral image, which combines the virtual image with the real scene, is successfully presented on the semi-transparent helmet. The position error of this navigation system is 0.96 ± 0.51 mm. This augmented reality system was applied in the clinic and good surgical outcomes were obtained. The augmented reality system that we established for maxillofacial surgery has the advantages of easy manipulation and high accuracy, which can improve surgical outcomes. Thus, this system exhibits significant potential in clinical applications.
Noninvasive quantification of blood potassium concentration from ECG in hemodialysis patients
Authors: Corsi Cristiana , Cortesi Marilisa , Callisesi Giulia , De Bie Johan , Napolitano Carlo , Santoro Antonio , Mortara David , Severi Stefano 
Published: February 2017

AbstractBlood potassium concentration ([K+]) influences the electrocardiogram (ECG), particularly T-wave morphology. We developed a new method to quantify [K+] from T-wave analysis and tested its clinical applicability on data from dialysis patients, in whom [K+] varies significantly during the therapy. To elucidate the mechanism linking [K+] and T-wave, we also analysed data from long QT syndrome type 2 (LQT2) patients, testing the hypothesis that our method would have underestimated [K+] in these patients. Moreover, a computational model was used to explore the physiological processes underlying our estimator at the cellular level. We analysed 12-lead ECGs from 45 haemodialysis and 12 LQT2 patients. T-wave amplitude and downslope were calculated from the first two eigenleads. The T-wave slope-to-amplitude ratio (TS/A) was used as starting point for an ECG-based [K+] estimate (KECG). Leave-one-out cross-validation was performed. Agreement between KECG and reference [K+] from blood samples was promising (error: −0.09 ± 0.59 mM, absolute error: 0.46 ± 0.39 mM). The analysis on LQT2 patients, also supported by the outcome of computational analysis, reinforces our interpretation that, at the cellular level, delayed-rectifier potassium current is a main contributor of KECG correlation to blood [K+]. Following a comprehensive validation, this method could be effectively applied to monitor patients at risk for hyper/hypokalemia.
Enrichment of circulating head and neck tumour cells using spiral microfluidic technology
Authors: Kulasinghe Arutha , Tran Thao Huynh Phuoc , Blick Tony , O’Byrne Ken , Thompson Erik W. , Warkiani Majid E. , Nelson Colleen , Kenny Liz , Punyadeera Chamindie 
Published: February 2017

AbstractWhilst locoregional control of head and neck cancers (HNCs) has improved over the last four decades, long-term survival has remained largely unchanged. A possible reason for this is that the rate of distant metastasis has not changed. Such disseminated disease is reflected in measurable levels of cancer cells in the blood of HNC patients, referred to as circulating tumour cells (CTCs). Numerous marker-independent techniques have been developed for CTC isolation and detection. Recently, microfluidics-based platforms have come to the fore to avoid molecular bias. In this pilot, proof of concept study, we evaluated the use of the spiral microfluidic chip for CTC enrichment and subsequent detection in HNC patients. CTCs were detected in 13/24 (54%) HNC patients, representing both early to late stages of disease. Importantly, in 7/13 CTC-positive patients, CTC clusters were observed. This is the first study to use spiral microfluidics technology for CTC enrichment in HNC.
Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice
Authors: Zhang Qingsheng , Esrafilzadeh Dorna , Crook Jeremy M. , Kapsa Robert , Stewart Elise M. , Tomaskovic-Crook Eva , Wallace Gordon G. , Huang Xu-Feng 
Published: February 2017

AbstractDeficits in neurite outgrowth, possibly involving dysregulation of risk genes neuregulin-1 (NRG1) and disrupted in schizophrenia 1 (DISC1) have been implicated in psychiatric disorders including schizophrenia. Electrical stimulation using conductive polymers has been shown to stimulate neurite outgrowth of differentiating human neural stem cells. This study investigated the use of the electroactive conductive polymer polypyrrole (Ppy) to counter impaired neurite outgrowth of primary pre-frontal cortical (PFC) neurons from NRG1-knock out (NRG1-KO) and DISC1-locus impairment (DISC1-LI) mice. Whereas NRG1-KO and DISC1-LI exhibited reduced neurite length and number of neurite branches compared to wild-type controls, this was not apparent for cultures on electroactive Ppy. Additionally, the use of the Ppy substrate normalised the synaptophysin and PSD95 protein and mRNA expression whereas both are usually reduced by NRG1-KO or DISC1-LI. Our findings support the utility of Ppy mediated electrical stimulation to prevent the reduction of neurite outgrowth and related synaptic protein expression in the primary PFC neurons from NRG1-KO and DISC1-LI mice, providing proof-of-concept for treating neurodevelopmental diseases including schizophrenia.
Real-time broadband terahertz spectroscopic imaging by using a high-sensitivity terahertz camera
Authors: Kanda Natsuki , Konishi Kuniaki , Nemoto Natsuki , Midorikawa Katsumi , Kuwata-Gonokami Makoto 
Published: February 2017

AbstractTerahertz (THz) imaging has a strong potential for applications because many molecules have fingerprint spectra in this frequency region. Spectroscopic imaging in the THz region is a promising technique to fully exploit this characteristic. However, the performance of conventional techniques is restricted by the requirement of multidimensional scanning, which implies an image data acquisition time of several minutes. In this study, we propose and demonstrate a novel broadband THz spectroscopic imaging method that enables real-time image acquisition using a high-sensitivity THz camera. By exploiting the two-dimensionality of the detector, a broadband multi-channel spectrometer near 1 THz was constructed with a reflection type diffraction grating and a high-power THz source. To demonstrate the advantages of the developed technique, we performed molecule-specific imaging and high-speed acquisition of two-dimensional (2D) images. Two different sugar molecules (lactose and D-fructose) were identified with fingerprint spectra, and their distributions in one-dimensional space were obtained at a fast video rate (15 frames per second). Combined with the one-dimensional (1D) mechanical scanning of the sample, two-dimensional molecule-specific images can be obtained only in a few seconds. Our method can be applied in various important fields such as security and biomedicine.