bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pressure assisted enhancement in superconducting properties of Fe substituted NbSe2 single crystal
Authors: Krishnan Manikandan , Pervin Rukshana , Ganesan Kalai Selvan , Murugesan Kannan , Lingannan Govindaraj , Verma Akshay Kumar , Shirage Parasharam M. , Sonachalam Arumugam 
Published: January 2018

AbstractThe impact of hydrostatic pressure (P) up to 1 GPa on T
c
, J
c
and the nature of the pinning mechanism in FexNbSe2 single crystals have been investigated within the framework of the collective theory. We found that the pressure can induce a transition from the regime where pinning is controlled by spatial variation in the critical transition temperature (δT
c
) to the regime controlled by spatial variation in the mean free path (δℓ). Furthermore, T
c
and low field J
c
are slightly induced, although the J
c
drops more rapidly at high fields than at ambient P. The pressure effect enhances the anisotropy and reduces the coherence length, resulting in weak interaction of the vortex cores with the pinning centers. Moreover, the P can induce the density of states, which, in turn, leads to enhance in T
c
with increasing P. P enhances the T
c
with the rates of dT
c
/dP of 0.86, 1.35 and 1.47 K/GPa for FexNbSe2, respectively. The magnetization data are used to establish a vortex phase diagram. The nature of the vortices has been determined from the scaling behaviour of the pinning force density extracted from the J
c
–H isotherms and demonstrates the point pinning mechanism.
Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease
Authors: Saito Hiroshi , Ishikawa Tatsuya , Tanabe Jun , Kobayashi Shinya , Moroi Junta 
Published: January 2018

AbstractThis pilot study aimed to investigate the utility of near-infrared spectroscopy/indocyanine green (NIRS/ICG) for examining patients with occlusive cerebrovascular disease. Twenty-nine patients with chronic-stage atherosclerotic occlusive cerebrovascular disease were included. The patients were monitored using NIRS at the bedside. Using ICG time-intensity curves, the affected-to-unaffected side ratios were calculated for several parameters, including the maximum ICG concentration (ΔICGmax), time to peak (TTP), rise time (RT), and blood flow index (BFI = ΔICGmax/RT), and were compared to the affected-to-unaffected side ratios of the regional cerebral blood flow (rCBF) and regional oxygen extraction fraction (rOEF) obtained using positron emission tomography with 15O-labeled gas. The BFI ratio showed the best correlation with the rCBF ratio among these parameters (r = 0.618; P = 0.0004), and the RT ratio showed the best correlation with the rOEF ratio (r = 0.593; P = 0.0007). The patients were further divided into reduced rCBF or elevated rOEF groups, and the analysis revealed significant related differences. The present results advance the measurement of ICG kinetics using NIRS as a useful tool for the detection of severely impaired perfusion with reduced rCBF or elevated rOEF. This method may be applicable as a monitoring tool for patients with acute ischemic stroke.
Expression and relevance of the G protein-gated K+ channel in the mouse ventricle
Authors: Anderson Allison , Kulkarni Kanchan , Marron Fernandez de Velasco Ezequiel , Carlblom Nicholas , Xia Zhilian , Nakano Atsushi , Martemyanov Kirill A. , Tolkacheva Elena G. , Wickman Kevin 
Published: January 2018

AbstractThe atrial G protein-gated inwardly rectifying K+(GIRK) channel is a critical mediator of parasympathetic influence on cardiac physiology. Here, we probed the details and relevance of the GIRK channel in mouse ventricle. mRNAs for the atrial GIRK channel subunits (GIRK1, GIRK4), M2 muscarinic receptor (M2R), and RGS6, a negative regulator of atrial GIRK-dependent signaling, were detected in mouse ventricle at relatively low levels. The cholinergic agonist carbachol (CCh) activated small GIRK currents in adult wild-type ventricular myocytes that exhibited relatively slow kinetics and low CCh sensitivity; these currents were absent in ventricular myocytes fromGirk1−/−orGirk4−/−mice. While loss of GIRK channels attenuated the CCh-induced shortening of action potential duration and suppression of ventricular myocyte excitability, selective ablation of GIRK channels in ventricle had no effect on heart rate, heart rate variability, or electrocardiogram parameters at baseline or after CCh injection. Additionally, loss of ventricular GIRK channels did not impact susceptibility to ventricular arrhythmias. These data suggest that the mouse ventricular GIRK channel is a GIRK1/GIRK4 heteromer, and show that while it contributes to the cholinergic suppression of ventricular myocyte excitability, this influence does not substantially impact cardiac physiology or ventricular arrhythmogenesis in the mouse.
Growth and remodeling play opposing roles during postnatal human heart valve development
Authors: Oomen Pim J. A. , Holland Maria A. , Bouten Carlijn V. C. , Kuhl Ellen , Loerakker Sandra 
Published: January 2018

AbstractTissue growth and remodeling are known to govern mechanical homeostasis in biological tissue, but their relative contributions to homeostasis remain unclear. Here, we use mechanical models, fueled by experimental findings, to demonstrate that growth and remodeling have different effects on heart valve stretch homeostasis during physiological postnatal development. Two developmental stages were considered: early-stage (from infant to adolescent) and late-stage (from adolescent to adult) development. Our models indicated that growth and remodeling play opposing roles in preserving tissue stretch and with time. During early-stage development, excessive tissue stretch was decreased by tissue growth and increased by remodeling. In contrast, during late-stage development tissue stretch was decreased by remodeling and increased by growth. Our findings contribute to an improved understanding of native heart valve adaptation throughout life, and are highly relevant for the development of tissue-engineered heart valves.
The ‘forma specialis’ issue in Fusarium: A case study in Fusarium solani f. sp. pisi
Authors: Šišić Adnan , Baćanović-Šišić Jelena , Al-Hatmi Abdullah M. S. , Karlovsky Petr , Ahmed Sarah A. , Maier Wolfgang , de Hoog G. Sybren , Finckh Maria R. 
Published: January 2018

AbstractThe Fusarium solani species complex (FSSC) has been studied intensively but its association with legumes, particularly under European agro-climatic conditions, is still poorly understood. In the present study, we investigated phylogenetic relationships and aggressiveness of 79 isolates of the FSSC collected from pea, subterranean clover, white clover and winter vetch grown under diverse agro-climatic and soil conditions within Temperate and Mediterranean Europe. The isolates were characterized by sequencing tef1 and rpb2 loci and by greenhouse aggressiveness assays. The majority of the isolates belonged to two lineages: the F. pisi comb. nov. lineage (formerly F. solani f. sp. pisi) mainly accommodating German and Swiss isolates, and the Fusisporium (Fusarium) solani lineage accommodating mainly Italian isolates. Based on the results of aggressiveness tests on pea, most of the isolates were classified as weakly to moderately aggressive. In addition, using one model strain, 62 accessions of 10 legume genera were evaluated for their potential to host F. pisi, the species known mainly as a pathogen of pea. A total of 58 accessions were colonized, with 25 of these being asymptomatic hosts. These results suggest a broad host range for F. pisi and challenge the forma specialis naming system in Fusarium.
LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor
Authors: Deba Farah , Ali Hamed I. , Tairu Abisola , Ramos Kara , Ali Jihad , Hamouda Ayman K. 
Published: January 2018

AbstractPositive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have potential therapeutic application in neuropathologies associated with decrease in function or loss of nAChRs. In this study, we characterize the pharmacological interactions of the nAChRs PAM, LY2087101, with the α4β2 nAChR using mutational and computational analyses. LY2087101 potentiated ACh-induced currents of low-sensitivity (α4)3(β2)2 and high-sensitivity (α4)2(β2)3 nAChRs with similar potencies albeit to a different maximum potentiation (potentiation I
max
= ~840 and 450%, respectively). Amino acid substitutions within the α4 subunit transmembrane domain [e.g. α4Leu256 and α4Leu260 within the transmembrane helix 1 (TM1); α4Phe316 within the TM3; and α4Gly613 within TM4] significantly reduced LY2087101 potentiation of (α4)3(β2)2 nAChR. The locations of these amino acid residues and LY2087101 computational docking analyses identify two LY2087101 binding sites: an intrasubunit binding site within the transmembrane helix bundle of α4 subunit at the level of α4Leu260/α4Phe316 and intersubunit binding site at the α4:α4 subunit interface at the level of α4Leu256/α4Ile315 with both sites extending toward the extracellular end of the transmembrane domain. We also show that desformylflustrabromine (dFBr) binds to these two sites identified for LY2087101. These results provide structural information that are pertinent to structure-based design of nAChR allosteric modulators.
Plasma MCP-1 and Cognitive Decline in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: A Two-year Follow-up Study
Authors: Lee Wei-Ju , Liao Yi-Chu , Wang Yen-Feng , Lin I-Feng , Wang Shuu-Jiun , Fuh Jong-Ling 
Published: January 2018

AbstractMonocyte chemoattractant protein-1 (MCP-1, also known as chemokine CCL2) is a vital chemokine that mediates inflammation in Alzheimer’s disease (AD). We analyzed the associations between the baseline plasma MCP-1 level, longitudinal cognitive changes, and genetic effects of CCL2 rs1024611 and its receptor, CC-chemokine receptor 2 (CCR2) rs1799864, in AD. In total, 310 AD patients and 66 mild cognitive impairment (MCI) patients were followed for 2 years, and 120 controls were recruited at baseline for comparison. After adjusting for covariates using one-way analysis of covariance, AD patients had higher plasma MCP-1 levels compared with MCI patients and controls, and severe AD patients had the highest levels. After adjusting for covariates using generalized estimating equation analysis, the results showed that the baseline MCP-1 level was significantly correlated with changes in the two-year Mini-Mental Status Examination (p = 0.046). The A allele of CCR2 rs1799864 was associated with a higher MCP-1 level in AD and MCI patients. In conclusion, plasma MCP-1 might reflect the risk and disease course of AD. A higher plasma MCP-1 level is associated with greater severity and faster cognitive decline. Additionally, the CCR2 polymorphism may play a role in the regulation of MCP-1/CCR2 signaling in AD.
Open‐loop per‐pin skew compensation with lock fault detector for parallel NAND flash memory interface
Authors: Kang K.‐T. , Kim S.‐Y. , Lee K.‐Y. 
Published: January 2018

An open‐loop per‐pin skew compensation with lock fault detection is presented. The proposed circuit employs an open‐loop reference selector, a two‐stage open‐loop delay lock method which is separated by a coarse and fine lock for fast lock‐in time, and a fault lock detecting scheme to prevent lock fault by dead zone of samplers. A unidirectional scan method ahead the fine lock stage to minimise pin‐to‐pin skew errors after calibration is also applied. The circuit was fabricated with 55 nm CMOS technology with a 1 V supply voltage and an area of 0.0036 mm2 for one de‐skewing module. The measured result shows that the skew error at 1 GHz operation was reduced to <6 ps after skew calibration when the skew between input/output (IO) pins was 230 ps, and the lock‐in time was 11 clock cycles.
Radio outburst from a massive (proto)star
Authors: Cesaroni R. , Moscadelli L. , Neri R. , Sanna A. , Caratti o Garatti A. , Eislöffel J. , Stecklum B. , Ray T. , Walmsley C. M. 
Published: January 2018

Context. Recent observations of the massive young stellar object S255 NIRS 3 have revealed a large increase in both methanol maser flux density and IR emission, which have been interpreted as the result of an accretion outburst, possibly due to instabilities in a circumstellar disk. This indicates that this type of accretion event could be common in young/forming early-type stars and in their lower mass siblings, and supports the idea that accretion onto the star may occur in a non-continuous way.
Aims. As accretion and ejection are believed to be tightly associated phenomena, we wanted to confirm the accretion interpretation of the outburst in S255 NIRS 3 by detecting the corresponding burst of the associated thermal jet.
Methods. We monitored the radio continuum emission from S255 NIRS 3 at four bands using the Karl G. Jansky Very Large Array. The millimetre continuum emission was also observed with both the Northern Extended Millimeter Array of IRAM and the Atacama Large Millimeter/Submillimeter Array.
Results. We have detected an exponential increase in the radio flux density from 6 to 45 GHz starting right after July 10, 2016, namely ~13 months after the estimated onset of the IR outburst. This is the first ever detection of a radio burst associated with an IR accretion outburst from a young stellar object. The flux density at all observed centimetre bands can be reproduced with a simple expanding jet model. At millimetre wavelengths we infer a marginal flux increase with respect to the literature values and we show this is due to free–free emission from the radio jet.
Conclusions. Our model fits indicate a significant increase in the jet opening angle and ionized mass loss rate with time. For the first time, we can estimate the ionization fraction in the jet and conclude that this must be low (<14%), lending strong support to the idea that the neutral component is dominant in thermal jets. Our findings strongly suggest that recurrent accretion + ejection episodes may be the main route to the formation of massive stars.
Treatment of Central Nervous System Tuberculosis
Authors: Ahmed Amina 
Published: January 2018

AbstractCentral nervous system tuberculosis (CNS-TB) manifests as tuberculous meningitis, intracranial tuberculoma, or spinal tuberculous arachnoiditis. Children are disproportionately affected, with high rates of mortality and morbidity reported even in the era of treatment. Most guidelines for the treatment of drug-susceptible CNS-TB recommend 9 to 12 months of a standard regimen of isoniazid, rifampin, pyrazinamide, and ethambutol, with the adjunctive use of corticosteroids early in therapy. Recent trials have demonstrated improved outcomes with intensified regimens using nonstandard regimens or higher dosages of standard drugs. Accumulating evidence also supports shorter duration of treatment. Further investigation is warranted to identify the optimal regimen and duration of treatment for CNS-TB. Complications such as hydrocephalus may be managed medically or surgically. Although outcomes have improved with effective chemotherapy and immunomodulation of disease, prompt diagnosis and treatment in the early stages of disease remain paramount to improve prognosis.
Endoscope-Assisted Microsurgical Removal of an Optic Foramen Meningioma through a Frontolateral Minicraniotomy
Authors: Kurucz Peter , Opitz Holger , Buchfelder Michael , Ganslandt Oliver 
Published: January 2018

AbstractA 72-year-old male patient with visual disturbance of the right eye was diagnosed with a small meningioma of the right optic foramen extending to the carotid cistern. The operation was performed through an individually tailored frontolateral minicraniotomy via a curvilinear skin incision behind the hairline. Endoscope-assisted microsurgical technique was used to resect the lesion. The roof of the optic canal was partly removed to get access to the intraforaminal tumor parts. The lesion could be completely removed and the patient showed a satisfactory visual recovery in the follow-up examinations.The link to the video can be found at: https://youtu.be/p8EZx7aryeQ.
Fat Mass and Obesity-Related Gene Variants rs9939609 and rs7185735 are Associated with Second-Generation Antipsychotic-Induced Weight Gain
Authors: Schröder Charlotte , Czerwensky Fabian , Leucht Stefan , Steimer Werner 
Published: January 2018

Abstract
Introduction Weight gain is a limiting and frequent adverse effect of second-generation antipsychotic therapy. Identifying genetic risk factors would significantly improve pharmacotherapy.
Methods We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity. Three-hundred fifty Caucasian inpatients were included in a naturalistic study.
Results After 4 weeks of treatment, we did not observe any significant association of polymorphisms with weight change in the whole study population (p>0.05). In a subpopulation without additional weight-inducing comedication (n=178), G-allele carriers of rs7185735 gained 3.4 times more weight (1.69 kg±3.1 kg, p=0.019) than AA genotypes (0.49 kg±3.1 kg). A-allele carriers of rs9939609 gained 3.1 times more weight (1.65 kg±3.1 kg, p=0.029) than TT genotypes (0.54 kg±3.2 kg).
Discussion Our findings confirm the role of the FTO gene as a high-potential risk factor for obesity and indicate a value for predicting a weight gain induced by second-generation antipsychotics. Further, we detected an additive effect of FTO rs7185735 and MC4R rs17782313.
Miranda Misconceptions of Criminal Detainees: Differences Based on Age Groups and Prior Arrests
Authors: Winningham Darby B. , Rogers Richard , Drogin Eric Y. 
Published: January 2018

Knowing and intelligent Miranda waivers remain the cornerstone of our 5th Amendment right against self-incrimination in the United States. Until recently, however, Miranda-related research and practice have focused almost entirely on comprehension of proffered warnings and waivers as opposed to identifying ingrained misconceptions that affect how detainees process this input. The current archival investigation brings together data on Miranda misconceptions for more than 799 detainees in the United States, ranging from 11–67 years of age. Miranda misconceptions were systematically examined on the Miranda Quiz (MQ) and parallel items of the Juvenile Miranda Quiz (JMQ) across four age groups (i.e., younger juveniles, older juveniles, emerging adults, and adults) with varying histories of prior arrests. As expected, the two adult groups had fewer Miranda misconceptions than the two juvenile groups. Contrary to widespread assumptions, serious Miranda misconceptions commonly occur, even among detainees with intact verbal abilities and those with extensive arrest histories.
Density-Dependent Conformable Space-time Fractional Diffusion-Reaction Equation and Its Exact Solutions
Authors: Hosseini Kamyar , Mayeli Peyman , Bekir Ahmet , Guner Ozkan 
Published: January 2018

Abstract

In this article, a special type of fractional differential equations (FDEs) named the density-dependent conformable fractional diffusion-reaction (DDCFDR) equation is studied. Aforementioned equation has a significant role in the modelling of some phenomena arising in the applied science. The well-organized methods, including the

exp
(
−
ϕ
(
ε
)
)

-expansion and modified Kudryashov methods are exerted to generate the exact solutions of this equation such that some of the solutions are new and have been reported for the first time. Results illustrate that both methods have a great performance in handling the DDCFDR equation.
The Vienna consensus: report of an expert meeting on the development of art laboratory performance indicators†‡
Authors:   ESHRE Special Interest Group of Embryology,   Alpha Scientists in Reproductive Medicine
Published: January 2018

AbstractSTUDY QUESTIONWhat are appropriate performance indicators (PIs) for ART laboratories for use in monitoring ‘fresh’ IVF and ICSI cycles?SUMMARY ANSWERMinimum performance (competence) levels and aspirational (benchmark) values were recommended for a total of 19 indicators, including 12 key PIs (KPIs), five PIs and two reference indicators (RIs).WHAT IS ALREADY KNOWNPIs are necessary for systematic monitoring of the laboratory and an important element within the Quality Management System. However, there are no established PIs for ART laboratories and there is very little evidence on the topic.STUDY DESIGN, SIZE, DURATIONThis is the report of a 2-day consensus meeting of expert professionals. As a starting point for the discussion, two surveys were organized to collect information on indicators used in IVF laboratories. During the meeting, the results of the surveys, scientific evidence (where available), and personal clinical experience where integrated into presentations by experts on specific topics. After presentation, each proposed indicator was discussed until consensus was reached within the panel.PARTICIPANTS/MATERIALS, SETTING, METHODSExpert professionals representing different countries and settings convened in the consensus meeting.MAIN RESULTS AND THE ROLE OF CHANCEThe paper is divided in two parts: the workshop report and the recommendations of the expert panel. The second part reflects the discussion on each of the indicators, with the agreed definition, competence level and benchmark value for each of the 19 indicators, including 12 KPIs, 5 PIs and 2 RIs.LIMITATIONS, REASONS FOR CAUTIONThe KPIs are mainly based on expert opinion. Future research may warrant an update of the recommended KPIs, their definition and the competence level and benchmark values.WIDER IMPLICATIONS OF THE FINDINGSBased on the information presented, each ART laboratory should select its own set of KPIs founded on laboratory organization, and processes.STUDY FUNDING/COMPETING INTEREST(S)The consensus meeting and writing of the paper was supported by funds from ESHRE and Alpha. Alpha gratefully acknowledges the following organizations for their financial support, through the provision of unrestricted educational grants: Global Fertility Alliance, Merck, Origio and Vitrolife. There are no conflicts of interest to disclose,
The dipole anisotropy of WISE × SuperCOSMOS number counts
Authors: Bengaly C A P , Novaes C P , Xavier H S , Bilicki M , Bernui A , Alcaniz J S 
Published: January 2018

Abstract
We probe the isotropy of the Universe with the largest all-sky photometric redshift data set currently available, namely WISE × SuperCOSMOS. We search for dipole anisotropy of galaxy number counts in multiple redshift shells within the 0.10 &lt; z &lt; 0.35 range, for two subsamples drawn from the same parent catalogue. Our results show that the dipole directions are in good agreement with most of the previous analyses in the literature, and in most redshift bins the dipole amplitudes are well consistent with Lambda cold dark matter-based mocks in the cleanest sample of this catalogue. In the z &lt; 0.15 range, however, we obtain a persistently large anisotropy in both subsamples of our data set. Overall, we report no significant evidence against the isotropy assumption in this catalogue except for the lowest redshift ranges. The origin of the latter discrepancy is unclear, and improved data may be needed to explain it.