bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Crystal Growth and Anisotropic Thermal Properties of the Nonlinear and Polar Oxide Cs2TeW3O12.
Authors: Feng Jiang‐He , Xiang Xu Jiang‐He , Mao Jiang‐Gao 
Published: December 2015

AbstractLarge crystals of Cs2TeW3O12 (20 x 15 x 4 mm) are grown by the top‐seeded solution growth method from mixtures of Cs2TeW3O12 and Cs2O and TeO2 as a flux (molar ratio1:1:4) or Cs2CO3, TeO2, and WO3 (molar ratio of 2:5:3) (Pt crucible, 700 °C, 3 d).
ChemInform Abstract: Chemical Synthesis and Characterization of γ‐Co2NiGa Nanoparticles with a Very High Curie Temperature.
Authors: Felser Claudia , et al.  
Published: December 2015

AbstractSingle‐phase γ‐Co2NiGa nanoparticles (NPs) are prepared by ultrasonication of a nearly stoichiometric MeOH dispersion of CoCl2, Ni(NO3)2, and Ga(NO3)3 hydrates to which colloidal silica is given followed by drying and annealing the resultant solid under H2 (1123 K, 2 h).
ChemInform Abstract: High Performance 5 V LiNi0.5Mn1.5O4 Spinel Cathode Materials Synthesized by an Improved Solid‐State Method.
Authors: Gao Zhi‐Gang , Sun Kai , Cong Li‐Na , Zhang Yu‐Hang , Zhao Qin , Wang Rong‐Shun , Xie Hai‐Ming , Sun Li‐Qun , Su Zhong‐Min 
Published: December 2015

AbstractLiNi0.5Mn1.5O4 is fabricated by ball milling of a stoichiometric mixture of LiOH, Ni(OAc)2, and Mn(OAc)2 (400 rpm, 20 h) followed by drying (100 °C, 10 h), calcination in either air or pure N2 (450 °C, 3 h), and finally calcination in air at 750 °C (cooling rate of 3 °C/min).
ChemInform Abstract: Prediction and Synthesis of Strain Tolerant RbCuTe Crystals Based on Rotation of One‐Dimensional Nano Ribbons within a Three‐Dimensional Inorganic Network.
Authors: Vermeer Michael J. DeVries , Zhang Xiuwen , Trimarchi Giancarlo , Donakowski Martin D. , Chupas Peter J. , Poeppelmeier Kenneth R. , Zunger Alex 
Published: December 2015

AbstractCrystals of RbCuTe are synthesized by vacuum annealing of the elements (sealed silica tube, 650 °C, 12 h).
ChemInform Abstract: Diastereoselective Addition of Monoorganocuprates to a Chiral Fumarate: Reaction Development and Synthesis of (‐)‐Dihydroprotolichesterinic Acid.
Authors: Hethcox J. Caleb , Shanahan Charles S. , Martin Stephen F. 
Published: December 2015

AbstractRecently reported diastereoselective conjugate addition of monoorganocuprates to chiral γ‐alkoxycrotonates and fumarates is applied to the shortest total synthesis of (‐)‐dihydroprotolichesterinic acid (VI) to date.
ChemInform Abstract: Organocatalytic Enantioselective Michael Reaction of Malononitrile with β,β‐Disubstituted Nitroalkenes.
Authors: Chen Shengwei , Lou Qinxin , Ding Yuyang , Zhang Shasha , Hu Wenhui , Zhao Junling 
Published: December 2015

AbstractAn enantioselective Michael reaction of malononitrile with β,β‐disubstituted nitro alkenes is presented.
ChemInform Abstract: A Metal‐Free Approach Toward Saturated N‐Propargyl Heterocycles via an Annulation/Decarboxylative Coupling Sequence.
Authors: Feng Huangdi , Jia Huihui , Sun Zhihua 
Published: December 2015

AbstractA three‐component reaction of primary 2‐ or 3‐amino alcohols with formaldehyde solution and propiolic acids affords N‐propargyl oxazolidines, 1,3‐oxazinanes and a thiazolidine in good yields.
ChemInform Abstract: Enantioselective Oxidation of Alkenes with Potassium Permanganate Catalyzed by Chiral Dicationic Bisguanidinium.
Authors: Wang Chao , Zong Lili , Tan Choon‐Hong 
Published: December 2015

AbstractThe title catalysts are used for the asymmetric dihydroxylation of α‐aryl acrylates and asymmetric oxohydroxylation of trisubstituted enoates.
ChemInform Abstract: Alkene Migration to the End‐Terminal Carbon Bearing a Phenyl Group over a Chiral Siloxy Carbon Center in Heck Reaction.
Authors: Ida Akiko , Hoshiya Naoyuki , Uenishi Jun'ichi 
Published: December 2015

AbstractThe Heck reaction of aryl bromide with a terminal alkene substrate having a chiral center at the allylic position and a phenyl substituent at another terminal carbon is reported.
ChemInform Abstract: Cross‐Coupling Between Aryl‐ and Alkenyldimethylsilanes and Organic Halides Promoted by a Copper(I) Iodide/Sodium Hydride/Ethylene Glycol System.
Authors: Takeda Takeshi , Takeda Yuichiro , Tsubouchi Akira 
Published: December 2015

AbstractA versatile cross‐coupling reaction of aryl‐ and alkenylsilanes (I) with various organic halides (II) is developed furnishing the corresponding cross‐coupling products (III) in good to excellent yields.
ChemInform Abstract: Efficient One‐Pot Synthesis of Dihydroquinolinones in Water at Room Temperature.
Authors: Linsenmeier Anna M. , Braje Wilfried M. 
Published: December 2015

AbstractArylboronic acids (IV) undergo Rh‐catalyzed 1,4‐addition to α,β‐unsaturated esters (II) and (VII) to give the corresponding addition products (V), (VI), and (VIII).
ChemInform Abstract: Rasta Resin‐TBD‐Catalyzed γ‐Selective Morita—Baylis—Hillman Reactions of α,γ‐Disubstituted Allenones.
Authors: Ma Shuang , Yang Yun‐Chin , Toy Patrick H. 
Published: December 2015

AbstractBoth superbase MTBD and the polystyrene‐based rasta resin‐supported analog RAS are used as catalysts for γ‐selective Morita—Baylis—Hillman reactions of α,γ‐disubstituted allenones (I).
ChemInform Abstract: Efficient Palladium‐Catalyzed C—H Fluorination of C(sp3)—H Bonds: Synthesis of β‐Fluorinated Carboxylic Acids.
Authors: Zhu Qihua , Ji Dezhong , Liang Tingting , Wang Xueyan , Xu Yungen 
Published: December 2015

AbstractConditions A) are highly suitable for the direct fluorination process and various functionalities are tolerated including amino acid derivative (III).
ChemInform Abstract: A Single Lipase‐Catalyzed One‐Pot Protocol Combining Aminolysis Resolution and Aza‐Michael Addition: An Easy and Efficient Way to Synthesise β‐Amino Acid Esters.
Authors: Xu Fan , Wu Qiongsi , Chen Xiaoyang , Lin Xianfu , Wu Qi 
Published: December 2015

AbstractEnantiopure β‐amino acid esters and chiral amides are simultaneously prepared by the title protocol.
ChemInform Abstract: An Efficient One‐Pot, Three‐Component Synthesis of Vinyl Sulfones via Iodide‐Catalyzed Radical Alkenylation.
Authors: Fan Weizheng , Su Jiapeng , Shi Dongyang , Feng Bainian 
Published: December 2015

AbstractVinylarenes and acrylates react with aryl‐ and alkyldiazonium salts in the presence of DABSO and TBHP as the oxidant to give the title compounds in high yields.
ChemInform Abstract: Application of a C—C Bond‐Forming Conjugate Addition Reaction in Asymmetric Dearomatization of β‐Naphthols.
Authors: Yang Dongxu , Wang Linqing , Kai Ming , Li Dan , Yao Xiaojun , Wang Rui 
Published: December 2015

AbstractA magnesium catalyst, generated in situ, is the active species in the title reaction which is applied to a broad spectrum of substituted naphthols and terminal propargylic ketones under conditions A).
ChemInform Abstract: Direct Construction of 3′,4′‐Dihydrospiro[pyrrol‐3,2′‐oxindoles] Through a Cascade Michael/Cyclization Reaction of 3‐Aminoindolin‐2‐ones with Enones/Enals.
Authors: Wang Dao‐Cai , Song Hang , Xu Chun‐Yun , Dong Hui , Liu Jie 
Published: December 2015

AbstractTitle compounds are efficiently synthesized through a cascade Michael/cyclization reaction.
ChemInform Abstract: Intramolecular Hydroalkoxylation of Unactivated Alkenes Using Silane—Iodine Catalytic System.
Authors: Fujita Shoji , Abe Masanori , Shibuya Masatoshi , Yamamoto Yoshihiko 
Published: December 2015

AbstractThe novel catalytic system is used successfully for the preparation of a broad spectrum of substituted furans and some pyran structures.
ChemInform Abstract: Stereoselective Synthesis of 3‐Carboxy‐4,5‐dihydropyrroles via an Intramolecular Iminium Ion Cyclization Reaction.
Authors: Xiang Jinbao , Xie Hongxiang , Li Zhuo , Dang Qun , Bai Xu 
Published: December 2015

AbstractWith exception of products (XIV)/(XV), treatment of Baylis—Hillman derivatives with aromatic aldehydes affords exclusively trans‐4,5‐disubstituted dihydropyrrole structures, important synthons in natural product and medicinal chemistry.
ChemInform Abstract: Methodology for Synthesis of Enantiopure 3,5‐Disubstituted Pyrrol‐2‐Ones.
Authors: Krenk Ondrej , Kratochvil Jiri , Spulak Marcel , Buchta Vladimir , Kunes Jiri , Novakova Lucie , Ghavre Mukund , Pour Milan 
Published: December 2015

AbstractThe title pyrroles are obtained by a linear synthetic route utilizing natural feedstocks and using different coupling agents at a late stage of the synthesis.
ChemInform Abstract: Synthesis of Constrained Analogues of Tryptophan.
Authors: Rossi Elisabetta , Pirovano Valentina , Negrato Marco , Abbiati Giorgio , Dell'Acqua Monica 
Published: December 2015

AbstractThe Lewis acid mediated diastereoselective [4 + 2]‐cycloaddition of vinylindoles [e.g. (I)] and acetamidoacrylate (II) gives tetrahydrocarbazoles [e.g.(III)], which can be further derived.
ChemInform Abstract: Isocyanide‐Based Multicomponent Reactions: Rapid Synthesis of a 5,5‐Fused Bicyclic Skeleton from α,β‐Unsaturated Ketones and Allenoates.
Authors: Xu Shibo , Su Shikuan , Zhang Huiting , Tian Lumin , Liang Pengcheng , Chen Jiawen , Zhang Yuan , Li Chunju , Jia Xueshun , Li Jian 
Published: December 2015

Abstract5,5‐Fused bicyclic compounds are efficiently obtained by reaction of various isocyanides, allenoates, and α,β‐unsaturated ketones via a cascade sequence involving a multiple Michael reaction, hydration, and intramolecular cyclization.
ChemInform Abstract: Synthesis of New Pyrazole Derivatives via Multicomponent Reaction and Evaluation of Their Antimicrobial and Antioxidant Activities.
Authors: Viveka Shivapura , Dinesha Shivapura , Madhu Leelavathi Narayana , Nagaraja Gundibasappa Karikannar 
Published: December 2015

AbstractA variety of new pyrazole derivatives bearing multifunctionalized pyrimidine [cf.
ChemInform Abstract: Morita—Baylis—Hillman Adducts as Building Blocks of Heterocycles: A Simple Approach to 4‐Substituted Pyrazolones, and Mechanism Investigation via ESI—MS(/MS).
Authors: Barcelos Rosimeire C. , Zeoly Lucas A. , Rodrigues Manoel T. Jr. , Ferreira Bruno R. V. , Eberlin Marcos N. , Coelho Fernando 
Published: December 2015

AbstractEfficient approaches for the synthesis of 4‐substituted dihydropyrazolones starting from readily available Morita—Baylis—Hillman adducts (III) are developed.
ChemInform Abstract: Further Studies on Sultones Derived from Carbene Cyclization Cycloaddition Cascades.
Authors: Gross Tobias , Herrmann Therese , Shi Bairu , Jaeger Anne , Chiu Pauline , Metz Peter 
Published: December 2015

AbstractThe rhodium‐catalyzed carbene cyclization‐cycloaddition cascade of a tosyl‐substituted diazoketone derivative to a polycyclic sultone is described.
ChemInform Abstract: Reductive Alkylation of 2‐Bromoazoles via Photoinduced Electron Transfer: A Versatile Strategy to C(sp2)—C(sp3) Coupled Products.
Authors: Arora Amandeep , Teegardin Kip A. , Weaver Jimmie D. 
Published: December 2015

AbstractThiazole, benzothiazole, benzimidazole, and substituted derivatives thereof are alkylated with a broad range of alkenes such as dihydropyran, norbornene, camphene, oxabicyclo[2.2.1]heptene, and steroid derivatives.
ChemInform Abstract: Electro‐Catalyzed Multicomponent Transformation of 3‐Methyl‐1‐phenyl‐1H‐pyrazol‐5(4H)‐one to 1,4‐Dihydropyrano[2,3‐c]pyrazole Derivatives in Green Medium.
Authors: Vafajoo Zahra , Hazeri Nourallah , Maghsoodlou Malek Taher , Veisi Hojat 
Published: December 2015

Abstract1,4‐Dihydropyrano[2,3‐c]pyrazole derivatives (IV) are efficiently and conveniently synthesized by using the electrogenerated anion of ethanol as the base in a one‐pot, three‐component condensation reaction.
ChemInform Abstract: Construction of Diverse and Functionalized 2H‐Chromenes by Organocatalytic Multicomponent Reactions.
Authors: Cai Hongyun , Xia Likai , Lee Yong Rok , Shim Jae‐Jin , Kim Sung Hong 
Published: December 2015

AbstractThis new and green procedure for the regioselective synthesis of functionalized 2H‐chromenes utilizes one‐pot, three‐component reactions between salicylaldehyde, electron‐deficient alkynes, and alcohols in the presence of L‐proline.
ChemInform Abstract: Base‐Promoted N‐Pyridylation of Heteroarenes Using N‐Propargyl Enaminones as Equivalents of Pyridine Scaffolds.
Authors: Cheng Guolin , Weng Yunxiang , Yang Xifa , Cui Xiuling 
Published: December 2015

AbstractN‐Propargyl enaminones, either in isolated form or generated in situ, are established as masked polysubstituted pyridine cores.
ChemInform Abstract: Synthesis of Quinolines by Visible‐Light Induced Radical Reaction of Vinyl Azides and α‐Carbonyl Benzyl Bromides.
Authors: Wang Qile , Huang Jun , Zhou Lei 
Published: December 2015

AbstractVisible‐light‐induced radical reaction of vinyl azides and α‐carbonyl benzyl bromides provides an efficient route to polysubstituted quinolines via a C—C and C—N bond formation sequence.
ChemInform Abstract: Metal‐Free Decarboxylative Cyclization/Ring Expansion: Construction of Five‐, Six‐, and Seven‐Membered Heterocycles from 2‐Alkynyl Benzaldehydes and Cyclic Amino Acids.
Authors: Samala Srinivas , Singh Gajendra , Kumar Ravi , Ampapathi Ravi Sankar , Kundu Bijoy 
Published: December 2015

AbstractWith a view to the synthesis of annulated polyheterocyclic systems, a broad spectrum of aromatic aldehyde substrates can be successfully applied in the reaction with cyclic amino acids.
ChemInform Abstract: Triple Aryne—Tetrazine Reaction Enabling Rapid Access to a New Class of Polyaromatic Heterocycles.
Authors: Suh Sung‐Eun , Barros Stephanie A. , Chenoweth David M. 
Published: December 2015

AbstractTetrazines (I) and (IV) react regioselectively with the in‐situ generated aryne to give the dibenzo[de,g]cinnolines (III), (V), and (VII) in low to moderate yields.
ChemInform Abstract: Cobalt(III)‐Catalyzed Directed C—H Allylation.
Authors: Gensch Tobias , Vasquez‐Cespedes Suhelen , Yu Da‐Gang , Glorius Frank 
Published: December 2015

AbstractN‐Pyrimidine‐protected indole, arenes and hetarenes equipped with an amide directing group as well as acrylamides are efficiently allylated using various allyl methyl carbonates.
ChemInform Abstract: Aerobic Photooxidative Synthesis of 2‐Aryl‐4‐quinazolinones from Aromatic Aldehydes and Aminobenzamide Using Catalytic Amounts of Molecular Iodine.
Authors: Nagasawa Y. , Matsusaki Y. , Nobuta T. , Tada N. , Miura T. , Itoh A. 
Published: December 2015

AbstractThe reaction is conducted by visible light irradiation.
ChemInform Abstract: T3P Catalyzed One Pot Three‐Component Synthesis of 2,3‐Disubstituted 3H‐Quinazolin‐4‐ones.
Authors: Raghavendra Goravanahalli M. , Pavan Kumar Chottanahalli S. , Suresha Gejjalagere P. , Rangappa Kanchugarakoppal S. , Mantelingu Kempegowda 
Published: December 2015

AbstractA series of title compounds is synthesized by a straightforward one‐pot three‐component reaction starting from anthranilic acid derivatives [(I) or (V), resp.].
ChemInform Abstract: A Facile and Concise Route Toward the Synthesis of Novel Imidazo‐tetrazolodiazepinones via Post‐Condensation Modifications of the Ugi‐Azide Adduct.
Authors: Medda Federico , Martinez‐Ariza Guillermo , Hulme Christopher 
Published: December 2015

AbstractPotentially biologically active imidazo‐tetrazolodiazepinones are prepared following a simple three‐step synthesis consisting of a four‐component Ugi‐reaction, transformation of the product to a tetrazolo‐hydantoin and deprotection with concomitant ring‐closure.
ChemInform Abstract: Aerobic Addition of Secondary Phosphine Oxides to Vinyl Sulfides: A Shortcut to 1‐Hydroxy‐2‐(organosulfanyl)ethyl(diorganyl)phosphine Oxides.
Authors: Malysheva Svetlana F , Artem'ev Alexander V. , Gusarova Nina K. , Belogorlova Nataliya A. , Albanov Alexander I. , Liu C. W. , Trofimov Boris A. 
Published: December 2015

AbstractThe title reaction proceeds under solvent‐free conditions without using any catalyst at 80°C.
ChemInform Abstract: Metal‐Catalyzed Stereoselective and Protecting‐Group‐Free Synthesis of 1,2‐cis‐Glycosides Using 4,6‐Dimethoxy‐1,3,5‐triazin‐2‐yl Glycosides as Glycosyl Donors.
Authors: Tanaka Tomonari , Kikuta Naoya , Kimura Yoshiharu , Shoda Shin‐ichiro 
Published: December 2015

AbstractThis title reaction is successfully applied not only to monosaccharides, but also to di‐ and oligosaccharides.
ChemInform Abstract: Antiviral Enantiomers of a Bisindole Alkaloid with a New Carbon Skeleton from the Roots of Isatis indigotica.
Authors: Shi Jian‐Gong , et al.  
Published: December 2015

AbstractA pair of indole alkaloid enantiomers, insatindibisindolamides A [(R)‐I] and B [(S)‐I] is isolated and separated.
ChemInform Abstract: Lanthanide Ion and Tetrathiafulvalene‐Based Ligand as a “Magic” Couple Toward Luminescence, Single Molecule Magnets, and Magnetostructural Correlations
Authors: Pointillart Fabrice , Le Guennic Boris , Cador Olivier , Maury Olivier , Ouahab Lahcene 
Published: December 2015

AbstractReview: 66 refs.
Microencapsulation of red and white thyme oil in poly(lactic‐co‐glycolic) acid: Assessment of encapsulation efficiency and antimicrobial capacity of the produced microcapsules
Authors: Moreira Ana C. G. , Martins Isabel M. , Fernandes Isabel , Barreiro Maria F. , Rodrigues Alírio E. 
Published: December 2015

AbstractIn this work, microcapsules were formed by coating thyme oil with a biodegradable polymer, poly(lactic‐co‐glycolic) acid (PLGA), through a coacervation process recently developed at our laboratory and previously studied for poly lactic acid (PLA). The coacervation method involves dissolution of the polymer (PLGA 50:50) in dimethylformamide. After adding this solution to the oil/water (o/w) emulsion, and due the insolubility of the polymer in water, polymer deposition occurs around the oil droplets and microcapsule formation starts. PLGA was chosen due to its easy biodegradation and biocompatibility. The active principle, thyme oil, is characterized by excellent antimicrobial activity ascribed to the presence of thymol and carvacrol, its major components. Two types of thyme oil (red and white) were microencapsulated and the produced microcapsules were characterized using optical microscopy, particle size analysis, and gas chromatography (used to evaluate encapsulation efficiency). Antimicrobial activity was preliminarily evaluated following ASTM E2149‐01. Microscopy and particle size analysis confirmed the existence of microcapsules with round shapes, smooth surfaces, particle diameters between ∼45–49 μm, and wall thicknesses ∼3.5 μm. Global encapsulation efficiencies of thyme oil (both red and white) were 70 % and 57 %, respectively. The produced microcapsules exhibited a sustained oil release that ensures a level of antimicrobial activity maintenance desirable for cosmetic applications.
Organ of Corti explants direct tonotopically graded morphology of spiral ganglion neurons in vitro
Authors: Smith Felicia L. , Davis Robin L. 
Published: December 2015

AbstractThe spiral ganglion is a compelling model system to examine how morphological form contributes to sensory function. While the ganglion is composed mainly of a single class of type I neurons that make simple one‐to‐one connections with inner hair cell sensory receptors, it has an elaborate overall morphological design. Specific features, such as soma size and axon outgrowth, are graded along the spiral contour of the cochlea. To begin to understand the interplay between different regulators of neuronal morphology, we cocultured neuron explants with peripheral target tissues removed from distinct cochlear locations. Interestingly, these “hair cell microisolates” were capable of both increasing and decreasing neuronal somata size, without adversely affecting survival. Moreover, axon characteristics elaborated de novo by the primary afferents in culture were systematically regulated by the sensory endorgan. Apparent peripheral nervous system (PNS)‐like and central nervous system (CNS)‐like axonal profiles were established in our cocultures allowing an analysis of putative PNS/CNS axon length ratios. As predicted from the in vivo organization, PNS‐like axon bundles elaborated by apical cocultures were longer than their basal counterparts and this phenotype was methodically altered when neuron explants were cocultured with microisolates from disparate cochlear regions. Thus, location‐dependent signals within the organ of Corti may set the “address” of neurons within the spiral ganglion, allowing them to elaborate the appropriate tonotopically associated morphological features in order to carry out their signaling function. J. Comp. Neurol. 524:2182–2207, 2016. © 2015 Wiley Periodicals, Inc.
Somatosensory organ topography across the star of the star‐nosed mole (Condylura cristata)
Authors: Sawyer Eva K. , Catania Kenneth C. 
Published: December 2015

ABSTRACTQuantifying somatosensory receptor distribution in glabrous skin is usually difficult because of the diversity of skin receptor subtypes and their location within the dermis and epidermis. However, the glabrous noses of moles are an exception. In most species of moles, the skin on the nose is covered with domed mechanosensory units known as an Eimer's organs. Eimer's organs contain a stereotyped array of different mechanosensory neurons, meaning that the distribution of mechanosensitive nerve endings can be inferred by visual inspection of the skin surface. Here we detail the distribution of Eimer's organs on the highly derived somatosensory star on the rostrum of the star‐nosed mole (Condylura cristata). The star consists of 22 fleshy appendages, or rays, that are covered in Eimer's organs. We find that the density of Eimer's organs increases from proximal to distal locations along the length of the star's rays with a ratio of 1:2.3:3.1 from the surface nearest to the nostril, to the middle part of ray, to the ray tip, respectively. This ratio is comparable to the increase in receptor unit density reported for the human hand, from the palm, to the middle of the digits, to the distal fingertips. We also note that the tactile fovea of the star‐nosed mole, located on the medial ventral ray, does not have increased sensory organ density, and we describe these findings in comparison with other sensory fovea. J. Comp. Neurol. 524:917–929, 2016. © 2015 Wiley Periodicals, Inc.
Distribution of the SynDIG4/proline‐rich transmembrane protein 1 in rat brain
Authors: Kirk Lyndsey M. , Ti Shu W. , Bishop Hannah I. , Orozco‐Llamas Mayra , Pham Michelle , Trimmer James S. , Díaz Elva 
Published: December 2015

ABSTRACTThe modulation of AMPA receptor (AMPAR) content at synapses is thought to be an underlying molecular mechanism of memory and learning. AMPAR content at synapses is highly plastic and is regulated by numerous AMPAR accessory transmembrane proteins such as TARPs, cornichons, and CKAMPs. SynDIG (synapse differentiation‐induced gene) defines a family of four genes (SynDIG1–4) expressed in distinct and overlapping patterns in the brain. SynDIG1 was previously identified as a novel transmembrane AMPAR‐associated protein that regulates synaptic strength. The related protein SynDIG4 [also known as Prrt1 (proline‐rich transmembrane protein 1)] has recently been identified as a component of AMPAR complexes. In this study, we show that SynDIG1 and SynDIG4 have distinct yet overlapping patterns of expression in the central nervous system, with SynDIG4 having especially prominent expression in the hippocampus and particularly within CA1. In contrast to SynDIG1 and other traditional AMPAR auxiliary subunits, SynDIG4 is de‐enriched at the postsynaptic density and colocalizes with extrasynaptic GluA1 puncta in primary dissociated neuron culture. These results indicate that, although SynDIG4 shares sequence similarity with SynDIG1, it might act through a unique mechanism as an auxiliary factor for extrasynaptic GluA1‐containing AMPARs. J. Comp. Neurol. 524:2266–2280, 2016. © 2015 Wiley Periodicals, Inc.