bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between oral health and mild cognitive impairment in community-dwelling older adults
Authors: Ye Niansi , Deng Bei , Hu Hui , Ai Yating , Liu Xueting , Zhou Shi , Li Yucan 
Published: October 2024

BackgroundOlder adults with cognitive impairment can experience poor oral health due to reduced self-care ability, yet the impact of various oral health indicators on the cognitive ability remains unclear. We investigated the relationship between oral health indicators and mild cognitive impairment (MCI) in older adults.MethodsA cross-sectional study of 234 older adults aged 65 years or over was performed form January to March 2023 at health screening departments of hospitals. This study used the Mini-mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living (ADL), Clinical Dementia Rating (CDR), and Hachinski Ischemic Score (HIS) to measure MCI. Two qualified dentists performed clinical oral examinations (number of teeth lost, dental caries, removable dentures, periodontitis). The other oral health status was measured by subjective assessment questionnaires, and the oral health-related quality of life (OHRQoL) was assessed by Geriatric Oral Health Assessment Index (GOHAI).ResultsOf the 234 older adults, 166 had MCI and 68 had normal cognitive ability. The univariate analyses revealed that older adults with poor oral health indicators of dental caries, mastication ability, oral and maxillofacial pain, self-perceived oral health status and OHRQoL had lower cognitive levels. The stepwise logistic regression analysis observed that higher education level (OR =  0.06, 95%CI = 0.007, 0.567) and OHRQoL score (OR = 0.92, 95%CI = 0.878, 0.963) were negatively associated with the presence of MCI. The area under the ROC curve (AUC) of MCI was 0.675 (95% CI: 0.600, 0.749) with a low sensitivity of 41.6% and a moderate specificity of 86.8%.ConclusionOHRQoL was found to be associated with MCI, implying that OHRQoL may be important in cognitive decline. The GOHAI scale can be used to more easily assess the oral health of older adults, which is important for the timely detection of poor oral status to delay cognitive decline.
Rural–urban differences in dental opioid prescribing among adolescent/young adult and adult Medicaid beneficiaries
Authors: Shoff Carla , Sheen Alex , Qu Luping , Chalmers Natalia I. 
Published: October 2024

IntroductionThere are ongoing concerns about opioid prescribing for surgical and non-surgical dental needs among adolescent/young adult and adult patients. Although there are known differences in the overall opioid prescription rates in rural areas compared to urban areas, the contribution of dental opioid prescriptions is still unclear. This study aims to examine the factors associated with receiving an opioid prescription following a dental visit.Materials and methodsThis cross-sectional study utilized the 2021 Centers for Medicare &amp; Medicaid Services unredacted Transformed Medicaid Statistical Information System Analytic Files to examine Medicaid and CHIP adolescent/young adult beneficiaries aged 12–20 and adults aged 21–64 who are non-dually eligible for Medicare and had a dental visit in 2021. Multilevel logistic regression models were used to predict the odds of receiving a dental opioid prescription.ResultsThe results of the adolescent/young adult models show that for every percentage point increase in the percentage of non-Hispanic Black residents in a county, the odds of receiving a dental opioid prescription increase by 0.8% in rural areas. However, with every percentage point increase in the Hispanic population, the odds of receiving a dental opioid prescription decrease by 0.3% in rural areas and 0.7% in urban areas. The adult models show that compared to non-Hispanic white beneficiaries, non-Hispanic Black beneficiaries are 8% more likely to receive a dental opioid prescription if they live in rural areas and 18% more likely if they live in urban areas, while all other racial and ethnic groups are significantly less likely to receive a dental opioid prescription. With every unit increase in the concentrated disadvantage index, the odds of receiving a dental opioid prescription increase by 17% among rural adults and 24% among urban adults.DiscussionOur findings on rural–urban disparities in opioid prescriptions suggest that prescription patterns in dental settings are significant and inequitable across various beneficiary- and county-level factors and areas of residence. These variations in prescription patterns highlight the known disparities in access to preventive dental care and the need for targeted interventions to address the healthcare needs of rural residents.
Communicating international politics narratives of security, democracy and human rights in contemporary society: indexing and analysis using online monitoring data
Authors: Olimid Anca Parmena , Georgescu Cătălina Maria , Gherghe Cosmin Lucian 
Published: October 2024

ObjectivesThe role of the current research is to set up a conceptual and analytical framework of the security, democracy and human rights linkage in contemporary society mainly based on the indexing, monitoring and research of online content for the period 1945–2019.Methods and methodologyDue to the focused timeline outlining the scientific research for the period 1945–2019, the paper favors both quantitative and qualitative approaches that follow a systemic framework of several thematic clusters which act as supporting pillars of analytical research by using Google Ngrams: (a) norms and constitutional values and principles; (b) civil and legal liberties; (c) human and individual approaches; (d) institutional governance and organizational establishment; (e) freedoms, civil and political rights.Results and discussionsThe research results explore the variations in the frequency of appearances of the selected concepts in the specialized literature indexed by the Google platform indicating essential aspects of the conceptual and theoretical evolutions in strict dependence to the significant resolutions of the Security Council of the United Nations adopted in the same period and focusing on three central concepts: security, democracy and human rights. The spectrum of research singles out fifteen figures and an integrated analysis of contextual, historical, political, institutional, legal and social factors.ConclusionThe research aims to expand the field of reference and analysis of the three notions of security, democracy and human rights by integrating the multifactorial and multi-conditional analysis for the interpretation of the results of the fifteen figures. In the broader framework of online monitoring and complementarily with the spectrum of UNSC resolutions, the research will use contemporary topics, intensely debated, used and monitored, focusing on the conceptual and linguistic study and on the relationship between the analytical inventory of scientific research and the international decision-making spectrum. This relationship is mediated by the lexicon of politics and the sociology of international relations, which reflected a growing evolutionary linguistic semantics since 1945, the year of the establishment of the United Nations.
FGF-2 enriched nanofiber scaffold for advancing achilles tendon healing: a comparative experimental investigation
Authors: Turgut Necmettin , Cengiz Çallıoğlu Funda , Bayraktar Aytül , Savran Mehtap , Aşcı Halil , Gülle Kanat , Ünal Meriç 
Published: October 2024

IntroductionAchilles tendon rupture is a common and debilitating injury that significantly impacts mobility and quality of life. Effective treatment options that promote faster and more complete healing are needed. Fibroblast growth factor-2 (FGF-2) has shown potential in enhancing tendon repair. This study aims to investigate the efficacy of FGF-2 in promoting tendon healing in a rat model of Achilles tendon rupture, providing insights into its potential as a therapeutic option.Materials and methodsForty-eight rat hind legs with complete Achilles tendon ruptures were divided into four equal groups: the Sham (S) group (tendon repair only), the Polymer (P) group (tendon repair with scaffold wrapping), the Produced FGF-2 (PF) group (scaffold coated with lab-produced FGF-2), and the Commercial FGF-2 (CF) group (scaffold coated with commercially sourced FGF-2). Histological analyses at two and four weeks post-surgery evaluated healing based on nuclear morphology, vascularity, fibril organization, inflammation, and adipogenesis.ResultsAt the end of the second week, no macroscopic healing was observed in one rat each from the S and P groups. By the end of the fourth week, macroscopic healing was observed in all groups. The S and P groups exhibited similarly severe fibril disorganization, pathological adipogenesis, and sustained inflammation, particularly at the fourth week. In contrast, the CF group demonstrated improved tendon healing with increased vascularity and extracellular matrix, lower inflammatory cell infiltration, and better fibril organization. Pathological adipogenesis was absent in the CF group, especially at the fourth week. The PF group showed comparable improvements at the second week but experienced a relapse by the 4th week, with increased inflammation and adipogenesis.ConclusionFGF-2 coated scaffolds significantly enhanced tendon healing in a rat Achilles tendon rupture model by improving fibril organization, increasing vascularity, and reducing inflammation and pathological adipogenesis. These findings suggest that FGF-2 could be a promising therapeutic option for accelerating tendon repair. Future perspectives on tendon repair will focus on enhancing FGF-2 delivery using innovative scaffolds, paving the way for more effective therapies and improved patient outcomes.
Robustness Assessment of Oncology Dose-Finding Trials Using the Modified Fragility Index
Authors: Shi Amy X. , Zhou Heng , Nie Lei , Lin Lifeng , Li Hongjian , Chu Haitao 
Published: October 2024

Objectives: The sample sizes of phase I trials are typically small; some designs may lead to inaccurate estimation of the maximum tolerated dose (MTD). The objective of this study was to propose a metric assessing whether the MTD decision is sensitive to enrolling a few additional subjects in a phase I dose-finding trial. Methods: Numerous model-based and model-assisted designs have been proposed to improve the efficiency and accuracy of finding the MTD. The Fragility Index (FI) is a widely used metric quantifying the statistical robustness of randomized controlled trials by estimating the number of events needed to change a statistically significant result to non-significant (or vice versa). We propose a modified Fragility Index (mFI), defined as the minimum number of additional participants required to potentially change the estimated MTD, to supplement existing designs identifying fragile phase I trial results. Findings: Three oncology trials were used to illustrate how to evaluate the fragility of phase I trials using mFI. The results showed that two of the trials were not sensitive to additional subjects’ participation while the third trial was quite fragile to one or two additional subjects. Conclusions: The mFI can be a useful metric assessing the fragility of phase I trials and facilitating robust identification of MTD.
Stratocorticium sinensis gen. et sp. nov. and Cericium gloeocystidiatum sp. nov. (Cyphellaceae, Agaricales) from East Asia
Authors: Zhang Yu-Peng , Li Yue , Nakasone Karen K. , He Shuang-Hui 
Published: October 2024

Cyphellaceae, a small and under-studied family of Agaricales, includes mostly saprophytic taxa with varied basidiomes. In this study, we focus on wood-decay species with corticioid or stereoid basidiomes. Phylogenetic analyses of concatenated ITS-nrLSU sequences uncovered seven generic lineages of corticioid or stereoid fungi—Acanthocorticium, Cericium, Chondrostereum, Cunninghammyces, Gloeostereum, Granulobasidium, and Stratocorticium gen. nov. The genus Cericium is shown to be in the Cyphellaceae family, and two new species, Cericium gloeocystidiatum and Stratocorticium sinensis, are described from East Asia. Morphologically, Ce. gloeocystidiatum is characterized by resupinate basidiomes with smooth hymenophores, a dimitic hyphal system with clamped generative hyphae and micro-binding hyphae, cystidia with resinous-like or golden yellow contents, and ellipsoid basidiospores. Stratocorticium is monotypic, differing from Cericium by a trimitic hyphal system of clamped generative, micro-binding, and brown, thick-walled skeletal-like hyphae, clavate to cylindrical cystidia with homogenous, colorless contents, and hyphidia. Descriptions and illustrations are provided for the new taxa and Cericium luteoincrustatum, and a key to corticioid or stereoid genera in Cyphellaceae is included.
Damage Evolution Mechanism of Railway Wagon Bogie Adapter 1035 Steel and Damage Parameter Calibration Based on Gursone–Tvergaarde–Needleman Model
Authors: Yin Jiachuan , Huang Xiaomin , Ma Guangzhi , Song Changzhe , Tang Xuefeng , Ji Hongchao 
Published: October 2024

As a critical component of a train, the railway wagon bogie adapter has higher quality requirements. During the forging process, external loads can induce voids, cracks, and other defects in the forging, thereby reducing its service life. Hence, studying the damage behavior of the forging material, specifically AISI 1035 steel, becomes crucial. This study involved obtaining stress–strain curves for AISI 1035 steel through uniaxial tensile tests at temperatures of 900 °C, 1000 °C, and 1100 °C, with strain rates of 0.1 s−1, 1 s−1, and 10 s−1. Subsequently, SEM was used to observe samples at various deformation stages. The damage parameters, q1, q2 and q3 in the GTN model “a computational model used to analyze and simulate material damage which can effectively capture the damage behavior of materials under different loading conditions” were then calibrated using the Ramberg–Osgood model and stress–strain curve fitting. Image Pro Plus software v11.1 quantified the sample porosity as f0, fn, fc and fF. A finite element model was established to simulate the tensile behavior of the AISI 1035 steel samples. By comparing the damage parameters of f0, fn, fc and fF obtained by the finite element method and experimental method, the validity of the damage parameters obtained by the finite element inverse method could be verified.
Influence of Particle Size on Flotation Separation of Ilmenite and Forsterite
Authors: Zhang Senpeng , Yang Yaohui , Wang Donghui , Yan Weiping , Li Weishi 
Published: October 2024

In addition to bubble–particle interaction, particle–particle interaction also has a significant influence on mineral flotation. Fine particles that coat the mineral surface prevent direct contact with collectors and/or air bubbles, thereby lowering flotation recovery. Calculating the particle interaction energy can help in evaluating the interaction behavior of particles. In this study, the floatability of coarse ilmenite (−151 + 74 μm) and different particle sizes (−45 + 25, −25 + 19, −19 μm) of forsterite with NaOL as a collector was investigated. The results showed that forsterite sizes of −45 + 25 and −25 + 19 μm had no effect on the ilmenite floatability, whereas −19 μm forsterite significantly reduced ilmenite floatability. A particle size analysis of artificially mixed minerals and a scanning electron microscopy (SEM) analysis of the flotation products showed that heterogeneous aggregation occurred between ilmenite and −19 μm forsterite particles. The extended DLVO (Derjaguin–Landau–Verwey–Overbeek) theory was applied to calculate the interaction energy between mineral particles using data from zeta potential and contact angle measurements. The results showed that the interaction barriers between ilmenite (−151 + 74 μm) and forsterite (−45 + 25, −25 + 19, and −19 μm) were 11.94 × 103 kT, 8.23 × 103 kT and 4.09 × 103 kT, respectively. Additionally, the interaction barrier between forsterite particles smaller than 19 μm was 0.51 × 103 kT. The strength of the barrier decreased as the size of the forsterite decreased. Therefore, fine forsterite particles and aggregated forsterite can easily overcome the energy barrier, coating the ilmenite particle surface. This explains the effect of different forsterite sizes on the floatability of ilmenite and the underlying mechanism of particle interaction.
Трансформация тромбоцитопении в тромбоцитоз на фоне присоединения первичного миелофиброза к миелодиспластическому синдрому (РАИБ-2): клиническое наблюдение
Authors: Берлина Н.В. , Абу-Хадир М. Р. , Ермолин В.В. 
Published: October 2024

Первичный миелофиброз – редкое Ph-негативное миелопролиферативное новообразование, характеризующееся фиброзом костного мозга, спленомегалией, экстрамедуллярным гемопоэзом. Источником опухолевого роста является клон трансформированных полипотентных гемопоэтических стволовых клеток. Тромбоцитоз может быть значимым гематологическим признаком на начальных стадиях заболевания. Здесь представлена эволюция тромбоцитопении в тромбоцитоз у пациента с первичным миелофиброзом, возникшим спустя несколько лет после установления диагноза миелодиспластического синдрома (МДС): рефрактерной анемии с избытком бластов. Описан процесс диагностики и лечения. Также приведен анализ литературных данных о клинических проявлениях и диагностике первичного миелофиброза.
Primary myelofibrosis is a rare Ph-negative myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, and extramedullary hematopoiesis. The source of tumor growth is a clone of transformed polypotent hematopoietic stem cells. Thrombocytosis may be a valuable hematological sign in the initial stages of the disease. The article describes the evolution of thrombocytopenia into thrombocytosis in a patient with primary myelofibrosis that manifested several years after the diagnosis of myelodysplastic syndrome (MDS): refractory anemia with excess of blasts. The process of diagnosis and treatment is described. An analysis of the literature data on the clinical manifestations and diagnosis of primary myelofibrosis is also provided.
Рефрактерное течение классической лимфомы Ходжкина, ассоциированной с вирусом Эпштейна – Барр
Authors: Гутник Ю.Д. , Марковец А.Ф. , Тарасевич И.В. 
Published: October 2024

В данной работе представлен клинический случай лимфомы Ходжкина, ассоциированной с вирусом Эпштейна – Барр (ВЭБ), у пациента 21 года с первично-рефрактерным течением заболевания, описана динамика изменения инструментальных и лабораторных показателей в течение лечения. Контроль над опухолевым процессом был достигнут применением иммунотерапии. Ингибиторы контрольных иммунных точек ниволумаб и пембролизумаб в комбинации с таргетным препаратом брентуксимабом ведотином позволили вывести пациента в полную метаболическую ремиссию перед аутологичной трансплантацией гемопоэтических стволовых клеток (ауто- ТГСК), показали свою эффективность в лечении рефрактерной лимфомы Ходжкина. Отмечена корреляция клинического течения заболевания и уровня ДНК ВЭБ в плазме крови пациента. ДНК ВЭБ у пациента с ЛХ может служить эффективным биомаркером активности опухолевого процесса.
This study presents a clinical case of Hodgkin lymphoma associated with Epstein – Barr virus (EBV) in a 21-year-old patient with a primary refractory disease, describes the dynamics of changes in instrumental and laboratory parameters during treatment. The control of the tumor process was achieved by the use of immunotherapy. Immune checkpoint inhibitors nivolumab and pembrolizumab in combination with brentuximab vedotin allowed the patient to enter complete metabolic remission before autologous hematopoietic stem cell transplantation (auto-HSCT), showed their effectiveness in the treatment of refractory Hodgkin’s lymphoma. There was a correlation between the clinical course of the disease and the level of EBV DNA in the patient’s blood plasma. EBV DNA in patients with LH can serve as an effective biomarker of tumor activity have shown their effectiveness in the treatment of refractory Hodgkin’s lymphoma.
An antibody nanopore-enabled microsensor for detection of osteoprotegerin
Authors: Feng Silu , Luo Qinglong , Song Xin 
Published: October 2024

Abstract
This paper introduces an antibody-based nanopore thin film sensor for detecting osteoprotegerin (OPG) in buffer solutions and serum samples, offering significant improvements over current commercial enzyme-linked immunosorbent assay kits in terms of cost, specificity, and selectivity. Capable of detecting OPG concentrations as low as 0.25 pg ml−1—far below the limits of traditional lab equipment—this sensor requires only about 1 μl of serum for effective measurement. The utilization of reference sensors helps reduce non-specific binding, enhancing the sensor’s accuracy. Its affordability and operational simplicity make it ideal for point-of-care monitoring of OPG levels in real-time patient care.
Towards the Assessment of Skid Trails in Logged-over Forest Using Drone Technology: A Review for the Timber Industry in Malaysia
Authors: Abdul Gapar Mohammad Ridzuan , Zainol @ Abdullah Wan Nor Zanariah , Che' Ya Nik Norasma 
Published: October 2024

Following the approval of the Detailed or Road Plan (DP) by the Forest Department of Sarawak (FDS) and subsequent field reconnaissance; the Licensee or the appointed contractor shall prepare the Reduced Impact Logging (RIL) Workmap for each harvesting block of timber. The skid trail layout within the block is part of the preparation of the RIL Workmap and skid trail alignment is one of the features in RIL Workmap. Skid trail planning involves making several decisions to avoid sensitive areas and optimise access to harvestable trees. The problem faced by Forest Management Unit (FMU) licensees is that there is no locally proven mechanism to assist them in identifying skid trails that can ensure minimal route length and high accessibility to harvestable trees. Proper planning of skid trails as timber harvesting routes in forests is an ongoing challenge and important to minimise environmental damage. Therefore, a study to identify skid trails in FMU is essential to assist licensees in their harvesting plan. The application of drone technology will be used as a tool to capture the image of skid trails in FMU before re-entry of the block for the harvesting process. This study would look at the single parameter affecting the skid trails which is the slope. Thus, this study will focus on the answer of; how the application of drones in identifying skid trails can assist FMU holders. In Sarawak, this research is very limited and still new, particularly in the operation of drones to identify skid trails. This additional scientific finding on the application of drones to identify skid trails in the logged-over forest, would help FMU in planning and practicing the RIL Guideline. Besides that, this study is also important to create innovative approaches using drone technology in the forest industry.