bluuebunny/crossref_metadata_2025_split huggingface dataset:
Langerhans Cell Histiocytosis Presenting as Isolated Hypothalamic Involvement
Authors: Chirag L. U. , Rao Shilpa , Girishan Shabari , Ramakrishna Manjunath Paidakula 
Published: September 2024

Background:
Obesity and associated primary amenorrhea are common presentations in the endocrinology outpatient department. Hypothalamic obesity is rare, and Langerhans cell histiocytosis (LCH) causing hypothalamic dysfunction is even more rare.

Clinical Description:
A 16-year-old girl presented with rapid weight gain over preceding 2 years, associated with headache for 2 months and primary amenorrhea. On examination, she had a weight and body mass index corroborating with obesity, while her height was age-appropriate. In addition, she had acanthosis nigricans but no Cushingoid features or intellectual disability. Systemic examination was normal.

Management and Outcome:
Considering a possibility of neuroendocrine cause of obesity, investigations were carried out. Bone age was delayed. Hormonal work-up revealed low estradiol, luteinizing hormone, and follicular stimulating hormone while thyroid function tests, growth hormone, and cortisol were normal, suggestive of hypogonadotropic hypogonadism. Magnetic resonance imaging of the brain revealed a mass in the hypothalamus region with a normal pituitary gland and stalk which was confirmed to be LCH on a stereotactic biopsy. Fluorodeoxyglucose-positron emission tomography showed no other sites of abnormal uptake. Thus, the child was diagnosed with a low-risk single-system LCH and treated accordingly.

Conclusion:
This case creates the awareness regarding the rare possibility of isolated hypothalamic involvement in LCH, causing obesity and primary amenorrhea, confirmed by biopsy.
Knowledge, Awareness, and Practice Regarding the Use of Phentolamine Mesylate: A Soft-tissue Local Anesthesia Reversal Agent among Dental Professionals – A Cross-Sectional Questionnaire Study
Authors: Kajave Krishna , Gokhale Niraj , Hugar Shivayogi M. , Kadam Krishna , Badakar Chandrashekhar , Sahai Varunika 
Published: September 2024

Background:
One of the drugs that is most frequently used in dentistry is local anesthetics. They are decisive while performing any dental procedure. The average length of a dental procedure is 47 min, but the local anesthetics used in standard dental procedures last between 1 and 3 h, with the most common inadequacy being the persistence of soft-tissue anesthesia (the numbness of the lips, cheeks, and tongue), which can persist for at least 3–5 h. This extended soft-tissue anesthetic in children can result in self-inflicted wounds like biting of the lips, tongue, or cheek.

Aim:
The study’s aim was to evaluate dental practitioners’ knowledge, awareness, and usage of phentolamine mesylate, a soft-tissue local anesthetic reversal agent.

Materials and Methods:
Two hundred and two dentists and graduate students participated in the study by filling out a validated questionnaire. The data obtained were entered into an Excel sheet and statistically analyzed using SPSS software version 22.0. It was observed that 66.50% of the participants had knowledge scores that were lower than the mean, 81.07% had awareness scores that were lower than the mean, and 91.26% had practice scores that were lower than the mean. With a very statistically significant P = 0.0001 (P = 0.05), Karl Pearson’s correlation coefficient revealed a positive correlation between knowledge, awareness, and practice.

Conclusion:
There was a general lack of knowledge about the drug phentolamine mesylate leading to lesser attitude, thereby leading to lesser use of the drug.
Young Consumer’s Awareness on Food Packet Labeling in Rural Tamil Nadu – A Convergent Mixed Methods Study
Authors: Selvamurthy Saranya , Rajalakshmi M. , Mohan Reenaa , Premanandh K. 
Published: September 2024

Background:
Food labeling is one medium by which consumers can acquire knowledge about the food they consider buying. This type of information is becoming increasingly important in a food market where direct contact with personnel over the counter is declining.

Objectives:
The objective of this study was to evaluate the level of awareness on food packet labeling and to explore the contributing factors of food packet label awareness among college students in Villupuram district, rural Tamil Nadu.

Methodology:
The study was carried out among 113 college students studying in Government Arts and Science College, Thiruvennainallur village, located in Villupuram district. A convergent mixed methods study design was used. A structured self-administered questionnaire was given to the students who participated in the National Nutrition Week awareness program. The questionnaire included variables such as checking for date of manufacturing, date of packaging, best-before date, storage conditions, lot number/code number/batch number, containing FSSAI code, and checking list of ingredients. In-depth interview was conducted among eight students who volunteered to explore the reasons for not checking food packet labels and solutions to improve the visibility of food package labeling. Categorical variables were summarized using percentages. Manual content analysis was done for in-depth interviews.

Results:
It was found that more than 90% of the study participants check for food packet labels, best-before dates, and date of packaging. However, more than half of the participants did not check for lot/code/batch number and storage conditions. The most common reason for not checking food labels was package-related factors such as font size very small, hidden, and hard to find and trust on brand and seller. The most common solution to improve the visibility of food labeling was increasing the font size and highlighting the important information.

Conclusions:
Our study highlights the level of awareness about food labels among youngsters and the solutions to improve the visibility of food labels. Need-based interventions have to be done to ensure the food safety of the consumers.
Association Between the Level of Vitamin D and COVID-19 Infection in Children and Adolescents: A Systematic Review
Authors: Ghoreshi Zohreh-Al-Sadat , Charostad Javad , Arefinia Nasir , Nakhaie Mohsen , Rezaei Zadeh Rukerd Mohammad , Zandi Aryan , Alizadeh Seyed Danial , Khoshnazar Seyedeh Mahdieh , Salajegheh Faranak 
Published: September 2024

ABSTRACT.
The COVID-19 pandemic has exerted a notable impact on worldwide health across diverse age groups. Although children and adolescents were initially considered less vulnerable, they have also shown susceptibility to the virus, emphasizing the importance of understanding associated risk factors. Epidemiological data reveal an increasing number of COVID-19 cases in this age group. The aim is to conduct a systematic assessment of the association between the level of vitamin D and COVID-19 infection in children and adolescents following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was performed across various databases up to October 7, 2023. Studies assessing laboratory-confirmed COVID-19 patients, the level of 25-hydroxyvitamin D in serum, and clinical outcomes were encompassed. Quality assessment was performed using the Newcastle–Ottawa Scale. Thirteen studies, conducted across six countries and involving 1,071 pediatric patients, were included. Vitamin D deficiency was prevalent among children and adolescents with COVID-19. Some studies suggested that vitamin D deficiency significantly increased the risk of COVID-19 infection and was linked to disease progression. Furthermore, deficiency in vitamin D demonstrated an association with increased levels of inflammatory markers, reduced lymphocyte counts, and heightened clinical symptoms, including fever and cough. Maintaining adequate vitamin D levels may be a crucial strategy for reducing COVID-19 severity and associated complications in children and adolescents. Nevertheless, there is a requirement for additional high-quality research to establish specific guidelines regarding vitamin D supplementation in this population amid the ongoing COVID-19 pandemic.
Pătarea brună a frunzelor cauzată de Paraconiothyrium tiliae (Rudolphi) Verkley & Gruyter – o boală rară a teilor în România
Authors: Olenici Nicolai 
Published: September 2024

Teiul cu frunza mică (Tilia cordata Mill.) este cea mai comună specie de tei din Europa și din România. Arborii acestei specii sunt în mai mare măsură afectați de boli și dăunători în orașe, decât în arborete. Între bolile care afectează frunzele de tei se află și cea cauzată de Paraconiothyrium tiliae (Rudolphi) Verkley & Gruyter, care se manifestă prin apariția unor pete mari, brune, cu marginea franjuată. Obiectivul lucrării este de a semnala prezența acestei specii în nordul țării noastre și de a investiga dacă a existat vreo legătură între apariția bolii și evoluția condițiilor meteorologice în cursul ultimelor trei sezoane de vegetație. Simptomele specifice observate (pete inițial mici, negre și cu structură fibrilară foarte evidentă, apoi pete tot mai mari, cu margine fin franjurată și înconjurate de o zonă galbenă, îngălbenirea, deformarea și căderea prematură a frunzelor), precum și perioada apariției lor, respectiv la începutul toamnei, corespund întru totul celor descrise și ilustrate în literatura de specialitate, confirmând faptul că este vorba despre ciuperca P. tiliae. Specia este semnalată pentru a doua oară în România, după 72 ani de la prima semnalare. Noile semnalări sunt din Câmpulung Moldovenesc, Vatra Moldoviței și Sucevița, județul Suceava. În toate aceste trei cazuri, ciuperca a fost găsită pe frunze ale unor arbori situați în apropierea unor cursuri de apă. Simptomele caracteristice bolii cauzate de această ciupercă au fost sesizate în anii 2021 și 2023, doi ani cu o vreme mai răcoroasă și mai ploioasă decât ar fi fost normal la sfârșitul primăverii și/sau începutul verii. Atacul cel mai intens s-a înregistrat la Câmpulung Moldovenesc, pe ramurile de la baza coroanelor unor arbori tineri crescuți printre arbori deși de molid care sunt plantați de-a lungul digului de pe malul drept al râului Moldova. Dată fiind raritatea ei și impactul redus asupra arborilor infectați, specia nu este importantă atât din punct de vedere fitosanitar, cât mai degrabă ca element de biodiversitate.
Evoluția regenerării naturale de stejar pedunculat într-un șleau de luncă din Ocolul silvic București în contextul aplicării degajărilor prin metode diferite
Authors: Ghinescu Mugurel Nicolae , Stancioiu Petru Tudor 
Published: September 2024

Lucrarea prezintă evoluția regenerării naturale instalate prin tăieri progresive într-un arboret de șleau de luncă. Cercetările au urmărit influența poziției în ochiurile de regenerare (marginea fertilă a ochiului; diferențe între zona centrală și cea de margine) precum și influența tipului de lucrare asupra creșterii regenerării naturale de stejar pedunculat din ochiuri. În acest sens, s-au aplicat lucrări de degajări în mod diferențiat: prin tăiere de jos a exemplarelor nedorite și prin frângerea exemplarelor nedorite la 1/3 și respectiv 1/2 din înălțimea stejarilor aleși a fi promovați. Pentru comparație, au fost lăsate și suprafețe neparcurse (martor). Rezultatele arată că marginea fertilă este în partea de sud-vest (dimensiunile puieților și biomasa lor au fost semnificativ mai mari în marginea aici față de marginea de nord-est) confirmând că factorul limitativ este uscăciunea estivală. Pentru toate variabilele măsurate (înălțime, diametru și biomasă totală supraterană), valorile au fost semnificativ mai mari în centrul ochiurilor față de margine. Așadar, în ciuda răririi arboretului între ochiuri, competiția cu arboretul matur pare să joace încă un rol important. Aplicarea diferențiată a lucrărilor, nu produce diferențe semnificative în zona centrală, deși apare o tendință ca tăierea de jos să conducă la arbori cu biomasă superioară față de celelalte două cazuri. La margine, unde domină competiția cu arboretul matern, situația este similară. Se observă însă efectul negativ asupra supraviețuirii stejarilor (numărul mediu fiind de doar 8,7 puieți pe suprafață de probă la margine, față de suprafețele intermediare și cele de centru, unde găsim 14,2, respectiv 13,1 puieți). Deci aplicarea lucrărilor la timp și cu consecvență rămâne un deziderat important. Întrucât puieții au atins deja (la doar șapte ani de la începerea tăierilor de regenerare) chiar și în marginea ochiurilor dimensiuni mult peste cele recomandate de normele tehnice silvice pentru aplicarea tăierilor de racordare, perioada de regenerare poate fi mai scurtă decât cea prevăzută în amenajament.
Activitatea de zbor a gândacilor de scoarță ai bradului, din genul Pityokteines, în perioada aprilie-iulie 2017, în zona Roznov – Neamț
Authors: Vasiliu Stelian , Duduman Mihai-Leonard , Cătălin Ciocan 
Published: September 2024

Gândacii de scoarță ai bradului din genul Pityokteines au un rol important în uscarea arboretelor de brad din România, în special a celor situate la altitudini sub 800 m. Monitorizarea activității de zbor a acestor insecte este o componentă esențială a măsurilor de depistare și prognoză. Pentru monitorizare se utilizează capcane de zbor amorsate cu nade feromonale sintetice specifice. În acest sens, în trei arborete de brad din zona Roznov, județul Neamț, amplasate altitudini cuprinse între 456 și 678 m, s-au instalat câte cinci capcane feromonale cu ajutorul cărora s-a urmărit activitatea de zbor a speciilor Pityokteines curvidens, P. vorontzowi și P. spinidens), în perioada 1 aprilie – 25 iunie 2017. S-au capturat 24321 gândaci, dintre care 23291 au fost exemplare de P. curvidens (95,8%), 659 exemplare de P. vorontzowi (2,7%) și 371 exemplare de P. spinidens (1,5 %). Masculii au reprezentat între 26,9 și 35,5 % din totalul capturilor în cazul lui P. curvidens, între 22,0 și 28,0 % în cazul lui P. vorontzowi și între 20,0 și 28,9% în cazul lui P. spinidens. Activitatea de zbor a celor trei specii de Pityokteines a fost asemănătoare, cu două maxime de zbor suprapuse în cazul speciilor P. curvidens și P. vorontzowi (8 aprilie și 3 iunie), pentru P. spinidens surprinzându-se doar un maxim de zbor, cel din 3 iunie. Variația altitudinală a diferențelor dintre capturile caracteristice primului maxim de zbor și celui de-al doilea, sau nesurprinderea primului maxim de zbor în cazul speciei P. spinidens, sugerează că zborul celor trei specii de Pityokteines s-a declanșat mai de vreme de 1 aprilie, pe fondul unei luni martie din 2017 mai călduroase decât ar fi normal. Ca urmare, în cazul acțiunilor de monitorizare a activității sezoniere de zbor a acestor insecte este necesară instalarea capcanelor feromonale cel târziu în ultima decadă a lunii martie, cel puțin în arboretele de brad situate la altitudini de 450-650 m. De asemenea, pentru a înțelege mai bine dinamica zborului speciilor de Pityokteines sunt necesare noi cercetări de teren efectuate cu ajutorul capcanelor feromonale și a arborilor cursă, în arborete de brad situate în condiții staționale cât mai diferite.
Immunophenotypes of systemic lupus erythematosus – features of clinical and laboratory disorders
Authors: Avdeeva Anastasia S. , Aleksankin Andrey P. , Tchetina Elena V. , Gorbunova Yu. N. , Popkova Tatiana V. , Markova Galina A. , Panafidina Tatiana A. , Nasonov Evgeny L. 
Published: September 2024

The aim – to evaluate subpopulations of B lymphocytes and features of interferon (IFN) status in patients with systemic lupus erythematosus (SLE), to clarify the relationship of immunological parameters with clinical manifestations of the diseaseMaterial and methods. 139 patients (123 (88%) women and 16 (12%) men) with a definite diagnosis of SLE were included in the analysis. The disease duration was 3.0 [0.3; 12.0] years, SLEDAI-2K (Systemic Lupus Erythematosus Disease Activity Index 2000) – 7 [4; 11] points, SDI (Systemic Lupus International Collaborating Clinics Damage Index) – 0 [0; 1] points. Immunophenotyping of peripheral blood lymphocytes, including determination of B cells, the general population of memory B cells, non-switched and switched memory B cells, naive, transient B cells, and plasmablasts was carried out using multicolor flow cytometry. IFN status was assessed by the expression of IFN-stimulated genes (MX1, RSAD2, EPSTI1) using real-time polymerase chain reactionResults. Two immunological “patterns” were identified – the prevailing immunological mechanism of the pathogenesis of the disease – SLE – with predominant activation of type I IFN and with predominant activation of the B cell component of the immune system. The immunological phenotype with activation of type I IFN was associated with high immunological activity, predominant skin damage, leukopenia, and the phenotype with predominant activation of the B cell link was associated with damage to the kidneys and nervous system.Conclusion. The results of the work suggest a wide variety of immune mechanisms underlying the pathogenesis of SLE. It is possible to identify a number of leading molecular “patterns” of the pathogenesis of the disease, which must be taken into account to select an effective “targeted” drug.
Features of systemic autoimmune disease associated with anti-Ku antibodies (descriptions of two clinical cases)
Authors: Torgashina Anna V. , Khelkovskaya-Sergeeva Anna N. , Abdykerimov Askat O. , Khalmetova Alsu R. 
Published: September 2024

Anti-Ku antibodies are a special type of myositis-associated antibodies that are characteristic of patients with the overlap syndrome of systemic scleroderma and immune-inflammatory myopathy, as well as occurring in other autoimmune diseases. Patients with these antibodies have their own clinical and laboratory features of the disease and can be identified as a separate anti-Ku syndrome.For the first time in the domestic literature, descriptions of two clinical cases of the development of a cross syndrome associated with anti-Ku antibodies are presented. The features of the course of the disease and the response to various options for immunosuppressive therapy were analyzed.
Analisis Hubungan Kepribadian The Big Five Terhadap Manajemen Konflik Pada Taruna AAU Dengan Metode Korelasi
Authors: Sibarani Jeffry Martahan , Suwito Suwito , Holimin Holimin 
Published: September 2024

Abstrak— Akademi Angkatan Udara bertugas menyelenggarakan pendidikan pertama perwira sukarela TNI Angkatan Udara. Penyelenggaran Pendidikan meliputi Aspek kepribadian (40%), Kognitif (30%) dan kesamaptaan (30%).Terlihat prosentasi pembinaan kepribadian mendapat porsi yang lebih, menunjukkan perlunya membentuk karakter taruna melalui pengasuhan. Penerapan hasil penelitian analisis hubungan kepribadian the big five terhadap manajemen konflik dengan metode korelasi dapat memetakan sifat dan sikap taruna dalam menghadapi persoalan. The Big Five Personality adalah teori kepribadian yang terbagi menjadi lima dimensi: openness, conscientiousness, extraversion, agreeableness, dan neuroticism. Teori lima besar atau ‘the big five’ model dikategorikan sebagai sifat kepribadian yang umum. The big five adalah organisasi dinamis dalam individu sebagai sistem psikofisis yang menentukan caranya yang khas dalam menyesuaikan diri terhadap lingkungan selain itu the big five juga menjelaskan hubungan antara kognisi, affect, dan tindakan. The big five adalah salah satu kepribadian yang dapat memprediksi dan menjelaskan perilaku seseorang. Pendekatan ini dapat digunakan untuk membantu sistem pengasuhan di Akademi Angkatan Udara dalam pembinaan taruna guna meminimalisir pelanggaran yang mungkin terjadi.
Design of Hand Stability Measuring Device for Shooting Training at the Air Force Academy
Authors: Ramananda Muhammad Syafiqi , Gastomo Bambang 
Published: September 2024

Tujuan penelitian ini adalah membuat rancang bangun alat pengukur getaran tangan petembak menggunakan sensor accelerometer MPU6050 berbasis mikrokontroler Arduino Uno. Begitu terjadi getaran pada tangan maka sensor accelerometer MPU6050 akan mengukur getaran tersebut dan mengirim datanya ke mikorokontroler Arduino Uno untuk kemudian ditampilkan di layar Liquid Cryatal Display (LCD) dan membunyikan komponen buzzer apabila getaran yang terdeteksi telah melebihi batas yaitu sebesar 0,3 G di setiap sumbu. Diharapkan dengan dibuatnya alat ini dapat menjadi solusi dari permasalahan yaitu perlu ditampilkannya data getaran tangan petembak untuk membantu proses latihan menembak di Akademi Aangkatan Udara (AAU)
Deep Learning model based on CNN using Keras and TensorFlow to determine real time melting point of chemical substances
Authors: Shrivastava Anurag 
Published: September 2024

Deep learning is a subset of machine learning that uses artificial neural networks inspired by human cognitive systems. Although this is a newly approach recently it became very popular and effective. In many applications deep learning become most successful approach where machine learning has been successful at certain rates. In the succession of these the proposed deep learning model is suitable for melting point detection apparatus which determine melting point of chemical substances this apparatus generally used in pharmaceutical and chemical industries. Proposed deep learning model classify images of chemical’s state (Solid or Liquid) by deep neural network (DNN) it consists of TensorFlow framework, libraries like Keras and activation function like ReLu, sigmoid, MaxPool and Flatten to determine melting point of chemical substances. The proposed model enables to TensorFlow architecture, which can determine the melting point of chemicals in real time on a single board computer. This use python as a programming language, TensorFlow framework and keras library. The input image data mainly focuses on chemical’s state, there are 2 categories of chemical’s state either solid or liquid. The Deep Neural Network (DNN) chosen as the best practice for the training process because it provides high accuracy. The results discussed in terms of the image classification accuracy in percentage. The images from two class label gets maximum accuracy is 99.72% and maximum validation accuracy is 99.37% same as liquid’s image and the average value of accuracy 84.17% or higher after certain epochs.
Seasonal Variations in Physico- chemical Parameters of the Sediment of Thengapatnam Estuary, South-coastal Region of India
Authors: Abisha P.R. 
Published: September 2024

The tremendous biodiversity and ecological processes that depend on freshwater and marine environments are essential to human survival. The physicochemical parameters in both surface waters and sediments are important to understand estuarine dynamics. The present study was carried out to determine how the seasonal variation will affect the physicochemical parameters of sediments of five stations in Thengapatnam estuary. Sediment samples were collected for a period of one year from June 2014-May 2015 from five different sampling stations. The parameters such as pH, temperature, Nitrogen, Phosphorous, Potassium, Copper, Zinc, Iron and Manganese were analysed using standard procedures. The result expose that, soil sediment have high amount of potassium in all five stations. Sediment temperature varied from 25.7- 30.1°C. Hydrogen ion concentration ranged between 6.9 to 8.3, concentrations of nutrients viz. nitrate (2.4 – 6.4 mg/100g), phosphate (1.5 - 15.25 mg/100g) potassium (138 – 560 ppm) and concentration of metals like iron, zinc and manganese were found to be higher during monsoon season and lower during premonsoon seasons The overall findings highlight the need for a scientific solution to reduce the use of harmful chemicals and heavy metal contamination from the river system in order to preserve the biodiversity of freshwater and marine ecosystems.