bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Borderline Personality Symptoms Associated With Compulsive Sexual Behaviors Among Women in Treatment for Substance Use Disorders? An Exploratory Study
Authors: Elmquist JoAnna , Shorey Ryan C. , Anderson Scott , Stuart Gregory L. 
Published: April 2016

ObjectiveExtant literature has documented a significant relationship between borderline symptoms and substance use disorders. As supported in past work, there is a significant theoretical relationship between borderline symptoms and compulsive sexual behaviors because both disorders share common underlying behaviors and traits. There is no known research that has examined the empirical relationship between borderline symptoms and compulsive sexual behaviors in a population with substance use disorders. To fill this important gap in the literature, this relationship was examined in the current study.MethodMedical records from 120 women admitted to a private, residential treatment program for substance use disorders were reviewed for the current study.ResultsHierarchical multiple regression analysis demonstrated that borderline symptoms were significantly associated with compulsive sexual behaviors after controlling for alcohol use and problems, drug use and problems, age, and positive impression management.ConclusionResults from this study provide potentially important research and clinical implications, which could ultimately aid treatment and reduce relapse. However, continued research is needed to further examine the relationship between symptoms and compulsive sexual behaviors.
Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Relationships of Etravirine in HIV‐1‐Infected, Treatment‐Experienced Children and Adolescents in PIANO
Authors: Kakuda Thomas N. , Brochot Anne , Green Bruce , Nijs Steven , Vis Peter , Opsomer Magda , Tomaka Frank L. , Hoetelmans Richard M. W. 
Published: April 2016

AbstractPIANO (NCT00665847) investigated etravirine pharmacokinetics, efficacy, and safety in children and adolescents. Treatment‐experienced, HIV‐1‐infected patients (≥6 to <18 years) received etravirine 5.2 mg/kg twice daily (maximum 200 mg twice daily) plus background antiretrovirals. A population pharmacokinetic model was developed, and etravirine C0h and AUC0‐12h were estimated. Relationships among intrinsic/extrinsic factors and etravirine pharmacokinetics and pharmacokinetics with pharmacodynamics were assessed. The best model describing etravirine pharmacokinetics consisted of a single compartment with sequential zero‐ and first‐order absorption following a lag time. Interindividual variability terms were included on clearance (CL/F) and the first‐order input rate constant (KA). The final model estimates (coefficient of variation, %) for CL/F and KA were 46.3 (11) L/h and 1.07 (34) h−1, respectively. Overall, median (range) estimated etravirine C0h and AUC0‐12h were 287 (2‐2276) ng/mL and 4560 (62‐28,865) ng · h/mL, respectively. Exposure was slightly lower in adolescents vs children. Sex and adherence did not affect etravirine pharmacokinetics. Factors significantly affecting etravirine exposure were body weight (higher with lower weight), race (lower in Asians than in white or black patients), and the use of certain HIV protease inhibitors. Virologic response (<50 copies/mL at week 48) was lower in the lowest etravirine AUC0‐12h quartile vs the upper 3 quartiles (41% vs 67% to 76%). Rash occurred more frequently in the highest quartile than in the lower 3 quartiles (52% versus 8% to 20%). Etravirine 5.2 mg/kg twice daily in treatment‐experienced, HIV‐1‐infected children and adolescents provides comparable exposure to that in adults receiving etravirine 200 mg twice daily and is the recommended dose for children and adolescents.
Magnetic adsorption separation process: an alternative method of mercury extracting from aqueous solution using modified chitosan coated Fe3O4 nanocomposites
Authors: Azari Ali , Gharibi Hamed , Kakavandi Babak , Ghanizadeh Ghader , Javid Allahbakhsh , Mahvi Amir Hossein , Sharafi Kiomars , Khosravia Touba 
Published: April 2016

AbstractBACKGROUNDIn the present work, Hg (II) is considered as one of the most dangerous elements being released excessively into the environment from various sources. Therefore, the aim of this study is the removal of Hg (II) from wastewater effluent by synthesizing a magnetic chitosan modified with glutaraldehyde (MCS‐GA) as an adsorbent. The composite structure was characterized using SEM/EDAX, FTIR, and XRD techniques. The adsorbent was tested by a batch system to determine the optimum conditions for removing Hg (II) under real conditions.RESULTSThe results showed that 0.5% GA effectively enhanced the removal efficiency. The maximum adsorption capacity of MCS‐GA was 96 mg g−1 at pH 5.0 and 25 °C. The adsorption isotherm data obeyed the Langmuir model (R2>0.981) and pseudo‐second‐order (R2>0.996) kinetic models. It was also found that Hg (II) adsorption on MCS‐GA is inherently exothermic and occurs spontaneously. The reusability of MCS‐GA was approved over 12 sequential cycles of adsorption–desorption. ANOVA analysis showed that the contact time has a synergistic effect on Hg (II) removal, whereas pH and initial concentration have antagonistic effects.CONCLUSIONOverall, the synthesized adsorbent was able to remove Hg (II) efficiently under both experimental and real conditions. © 2016 Society of Chemical Industry
Influence of reaction conditions on the self‐assembly of the natural silk sericin protein
Authors: Li Wenhua , Su Xiuping , Zhong Qiwei , Liu Zhaogang , Cai Yurong , Yao Juming 
Published: April 2016

ABSTRACTIn the past years, the self‐assembly of specific proteins has been paid more and more attention due to their significant role in human health and fabrication of new materials. In this article, we explore the effect of reaction conditions on the self‐assembly of natural silk sericin protein, including the molecular weight and the concentration of sericin, pH, and metal ions in the reaction system. The results indicate that all these factors, especially species and concentration of metal ions, could influence the self‐assembly process of the silk sericin protein. A series of assemblies with various morphologies can be fabricated by modulating the reaction condition. The article may provide some clue for the understanding of the protein self‐assembly in the body and a method to fabricate new organic materials with different morphology. Microsc. Res. Tech. 80:298–304, 2017. © 2016 Wiley Periodicals, Inc.
Comparison of clinicopathological characteristics between patients with occupational and non‐occupational intrahepatic cholangiocarcinoma
Authors: Hamano Genya , Kubo Shoji , Takemura Shigekazu , Tanaka Shogo , Shinkawa Hiroji , Kinoshita Masahiko , Ito Tokuji , Yamamoto Takatsugu , Wakasa Kenichi , Shibata Toshihiko 
Published: April 2016

AbstractBackgroundAn outbreak of cholangiocarcinoma has been reported among workers of an offset color proof‐printing department at a printing company in Japan. In this study, we compared the clinicopathological findings of this type of intrahepatic cholangiocarcinoma (occupational ICC) and non‐occupational ICC.MethodsThe clinical records of 51 patients with perihilar‐type ICC who underwent liver resection, including five patients with occupational ICC were retrospectively reviewed. The clinicopathological features were compared.ResultsIn the occupational group, the patients were significantly younger (P < 0.01), while serum γ‐glutamyl transpeptidase activity and the proportions of patients with regional dilatation of the bile ducts without tumor‐induced obstruction were significantly higher (P = 0.041 and P < 0.01, respectively); the indocyanine green retention rate at 15 min was significantly lower (P = 0.020). On pathological examinations, precancerous or early cancerous lesions, such as biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct, were observed at various sites of the bile ducts in all occupational ICC patients; such lesions were observed in only six patients in the control group (P < 0.01).ConclusionsThe clinicopathological findings including age, liver function test results, diagnostic imaging findings, and pathological findings differed between the occupational and control groups.
Automation of [18F]fluoroacetaldehyde synthesis: application to a recombinant human interleukin‐1 receptor antagonist (rhIL‐1RA)
Authors: Morris Olivia , McMahon Adam , Boutin Herve , Grigg Julian , Prenant Christian 
Published: April 2016

[18F]Fluoroacetaldehyde is a biocompatible prosthetic group that has been implemented pre‐clinically using a semi‐automated remotely controlled system. Automation of radiosyntheses permits use of higher levels of [18F]fluoride whilst minimising radiochemist exposure and enhancing reproducibility. In order to achieve full‐automation of [18F]fluoroacetaldehyde peptide radiolabelling, a customised GE Tracerlab FX‐FN with fully programmed automated synthesis was developed.The automated synthesis of [18F]fluoroacetaldehyde is carried out using a commercially available precursor, with reproducible yields of 26% ± 3 (decay‐corrected, n = 10) within 45 min. Fully automated radiolabelling of a protein, recombinant human interleukin‐1 receptor antagonist (rhIL‐1RA), with [18F]fluoroacetaldehyde was achieved within 2 h. Radiolabelling efficiency of rhIL‐1RA with [18F]fluoroacetaldehyde was confirmed using HPLC and reached 20% ± 10 (n = 5).Overall RCY of [18F]rhIL‐1RA was 5% ± 2 (decay‐corrected, n = 5) within 2 h starting from 35 to 40 GBq of [18F]fluoride. Specific activity measurements of 8.11–13.5 GBq/µmol were attained (n = 5), a near three‐fold improvement of those achieved using the semi‐automated approach.The strategy can be applied to radiolabelling a range of peptides and proteins with [18F]fluoroacetaldehyde analogous to other aldehyde‐bearing prosthetic groups, yet automation of the method provides reproducibility thereby aiding translation to Good Manufacturing Practice manufacture and the transformation from pre‐clinical to clinical production.
Labeling and evaluation of 99mTc‐tricarbonyl‐meloxicam as a preferential COX‐2 inhibitor for inflammation imaging
Authors: Erfani Mostafa , Sharifzadeh Somayeh , Doroudi Alireza , Shafiei Mohammad 
Published: April 2016

Imaging of inflammation has an important role in dissolving problems in diagnosis and therapy of patients with inflammatory disorders. In this study meloxican as a nonsteroidal anti‐inflammatory drug (NSAID) has been labeled with thechnetium‐99m‐tricarbonyl core ([99mTc (CO)3 (H2O)3]+) in order to evaluate its feasibility as an inflammation imaging agent for in vivo use.99mTc‐tricabonyl labeling of meloxicam was performed by its incubation with prepared precursor 99mTc‐tricabonyl and heating in a boiling water bath for 30 min while various range of pH (1–9) was adjusted. The stability of 99mTc‐tricarbonyl‐Meloxicam was checked in human serum at 37 °C, and biodistribution was studied in mice. Labeling yield of 98.1 ± 0.4% was obtained corresponding to a specific activity of 0.14 GBq/µmol. The radioconjugate showed good stability in human serum. Our main achievement was high accumulation of 99mTc‐tricarbonyl‐Meloxicam in the inflammated muscle in mice (T/NT = 3.90 at 4 h post injection) which may diagnostically be beneficial for distinguish sites of inflammation.
Analysis of arch‐like bones: The rodent mandible as a case study
Authors: Vassallo Aldo Iván 
Published: April 2016

ABSTRACTBone strength is determined by the mechanical properties of bone material, and the size and shape of the whole bone, i.e., its architecture. The mandible of vertebrates has been traditionally regarded as a beam oriented in relation to main masticatory loads, i.e., the longer dimension of its cross‐section being parallel to the load. Rodents follow this pattern but, in addition, their mandible possesses an intriguing arch‐like shape that is apparent when seen in the lateral view. Little attention was given to the structural capacity of this trait. The advantage of an arch is that it can withstand a greater load than a horizontal beam. The objective of this study was to model the rodent mandible like an arch to evaluate its structural strength. The bending moment in an arch‐like mandible was 15–25% lower with respect to a beam‐like mandible. Further, bending varies with mandible “slenderness” and incisor procumbency, a functionally relevant rodent trait. In the rodent Ctenomys talarum (Caviomorpha; Ctenomyidae), bone stress was substantially reduced when the mandible was modeled as an arch‐like structure as compared with a beam‐like structure, and safety factors were 15–34% higher. The shape of rodents' mandible might confer a functional advantage to high and repeatedly applied loads resulting from a unique feeding mode: gnawing. J. Morphol. 277:879–887, 2016. © 2016 Wiley Periodicals, Inc.
The spleen and skin wound healing in Xenopus adults
Authors: Franchini Antonella , Della Rocca Annalaura , Bertolotti Evelina 
Published: April 2016

ABSTRACTIn most vertebrates, the regenerative capacity to restore lost/damage tissues to original structure and functionality decreases at some time during ontogenesis. To evaluate the role of the acquired immunity in the decline of regenerative potential, we examined the cellular responses elicited in the spleen during skin repair in Xenopus adults. Modifications in the architecture were found to be induced and were remarkable 14 days postinjury when the spleen increased significantly in size. In white pulp, the periarteriolar lymphoid sheaths were associated with follicles having central light zones, morphologically similar to germinal centers. With the progress of healing, pigment‐containing cells were seen to accumulate in both white and red pulp regions. Moreover, compared to controls, the cells immunoreactive to anti‐cytokines (TNF‐α, TGF‐β1) and ‐iNOS increased from the first days after wounding. The 14th day, the positive cells formed a dense network of reticular cells in central regions of lymphoid follicles and more frequent reactive leukocytes were detected within the red pulp. A higher number of lymphoid cells immunostained with anti‐CD3ε were also observed in the perifollicular zone. The results suggest that the spleen of adult frogs is involved in skin wound healing with the expansion of lymphoid compartments. J. Morphol. 277:888–895, 2016. © 2016 Wiley Periodicals, Inc.
Effect of team training on improving MRI study completion rates and no‐show rates
Authors: Norbash Alexander , Yucel Kent , Yuh William , Doros Gheorghe , Ajam Amna , Lang Elvira , Pauker Stephen , Mayr Nina 
Published: April 2016

PurposeMagnetic resonance imaging (MRI) is a high‐cost imaging modality, and an optimized encounter ideally provides high‐quality care, patient satisfaction, and capacity utilization. Our purpose was to assess the effectiveness of team training and its impact on patient show‐up and completion rates for their MRI examinations.Materials and MethodsA total of 97,712 patient visits from three tertiary academic medical centers over 1‐year intervals were evaluated, totaling 49,733 visits at baseline and 47,979 after training. Each center's MRI team received team training skill training including advanced communication and team training techniques training. This training included onsite instruction including case simulation with scenarios requiring appropriate behavioral and communicative interventions. Orientation and training also utilized customized online tools and proctoring. The study completion rate and patient show‐up rate during consecutive year‐long intervals before and after team training were compared to assess its effectiveness. Two‐sided chi‐square tests for proportions using were applied at a 0.05 significance level.ResultsDespite differing no‐show rates (5–22.2%) and study incompletion rates (0.7–3.7%) at the three academic centers, the combined patients' data showed significant (P < 0.0001) improvement in the patients' no‐show rates (combined decreases from 11.2% to 8.7%) and incompletion rates (combined decreases from 2.3% to 1.4%).ConclusionOur preliminary results suggest training of the imaging team can improve the no‐show and incompletion rates of the MRI service, positively affecting throughput and utilization. Team training can be readily implemented and may help address the needs of the current cost‐conscious and consumer‐sensitive healthcare environment. J. MAGN. RESON. IMAGING 2016;44:1040–1047.
Histological validation of cardiac magnetic resonance T1 mapping for detecting diffuse myocardial fibrosis in diabetic rabbits
Authors: Zeng Mu , Zhang Nan , He Yi , Wen Zhaoying , Wang Zhanhong , Zhao Yike , Greiser Andreas , An Jing , Zhang Tianjing , Jing Bin , Zhang Xin , Fan Zhanming , Li Debiao 
Published: April 2016

PurposeTo pathologically verify the correlation between native T1 mapping, postcontrast T1 mapping, and extracellular volume fraction (ECV) and myocardial diffuse fibrosis, as determined by collagen volume fraction (CVF).Materials and MethodsThirty New Zealand white rabbits were randomly divided into the control group (n = 6), diabetes 3 months group (n = 8), diabetes 6 months group (n = 8), and diabetes 9 months group (n = 8). All the rabbits underwent clinical 3.0T magnetic resonance (MR) examinations with pre‐ and postcontrast modified Look–Locker inversion recovery T1 mapping. For the histological study, each rabbit was sacrificed after MR scanning, hematoxylin and eosin and Masson staining of the left ventricular myocardium were performed, and CVF was calculated. Pre‐ and postcontrast T1 values and ECV were compared to CVF using Pearson's correlation coefficients.ResultsTwo rabbits died in each diabetes group, thus each group included six rabbits. ECV calculated from pre‐ and postcontrast T1 values showed a very strong correlation with CVF (r = 0.876, P < 0.001), whereas postcontrast T1 values exhibited a moderate correlation with CVF (r = –0.564, P = 0.004). In contrast, precontrast T1 values showed no correlation with CVF (r = 0.311, P = 0.139).ConclusionECV has a very strong correlation with pathological CVF, and can be used to assess the degree of diffuse myocardial fibrosis better than the postcontrast T1 value. Precontrast T1 value has no significant correlation with diffuse myocardial fibrosis. J. Magn. Reson. Imaging 2016;44:1179–1185.
Long‐term outcomes following post‐operative radiotherapy for Stage I/II testicular seminoma – an Australasian single‐institution experience
Authors: Ong Wee Loon , Nazareth Lester , Hindson Benjamin , Matheson Bronwyn , Millar Jeremy L 
Published: April 2016

AbstractIntroductionThe aim of the study is to review the long‐term oncological outcomes and adverse effects of post‐operative radiotherapy (PORT) for Stage I/II seminoma patients in an Australian radiation treatment centre.MethodsThis is a retrospective study of 125 patients with Stage I/II seminoma treated with PORT at the Alfred Health Radiation Oncology Service between 1992 and 2013. Patients were linked to the Victorian Cancer Registry to enable confirmation of survival and diagnosis of secondary malignancies (SM). The relapse‐free survival (RFS), testicular‐cancer‐specific survival (TCSS), overall survival (OS) and SM‐free survival (SMFS) were estimated with Kaplan–Meier methods.ResultsThe median age at diagnosis was 36 (range 20–62). The median time between diagnosis and PORT was 1.6 months (range: 0.5–4.5). Fifty patients (40%) had PORT to the para‐aortic (PA) target alone, while the remaining had PORT to PA and ipsilateral or bilateral iliac lymph nodes. There were no acute adverse effects requiring admission. The median follow‐up after PORT was 7.8 years (range = 0.1–19.1). There were two relapses, both of which occurred within 1 year of PORT (estimated 10‐year RFS = 98.4%). Five deaths were reported, none of which were testicular cancer‐related death (estimated 10‐year TCSS = 100%, 10‐year OS = 97.3%). There were seven SM (one lower lip cancer, one upper shoulder melanoma, one mesothelioma, two prostate cancer, one acute myeloid leukaemia and one contralateral testicular seminoma) reported in six patients, with estimated 10‐year SMFS of 92.9%.ConclusionOur series confirms excellent oncological outcomes among patients with Stage I/II seminoma treated with PORT, with uncommon occurrence of SM.
Influence of trabecular bone quality and implantation direction on press‐fit mechanics
Authors: Damm Niklas B. , Morlock Michael M. , Bishop Nicholas E. 
Published: April 2016

ABSTRACTAchieving primary stability of uncemented press‐fit prostheses in patients with poor quality bone can involve axial implantation forces large enough to cause bone fracture. Radial implantation eliminates intraoperative impaction forces and could prevent this damage. Platens of two commercial implant surfaces (“Beaded” and “Flaked”) were implanted onto trabecular bone specimens of varying quality in a press‐fit simulator. Samples were implanted with varying interference, either axially (shear) or radially (normal). Push‐in and pull‐out forces were measured to assess stability. Microstructural changes in the bone were determined from μCT analysis. For force‐defined implantation analysis, push‐in and pull‐out forces both increased proportionally with increasing radial force, independent of implantation direction, bone quality or implant surface. For position‐defined implantation analysis, pull‐out forces were generally found to increase with interference and to be greater for radial than axial implantation direction, and to be lower for poor quality bone. Bone density increased locally at the tested interface due to implantation, in particular for the Beaded surface under axial implantation. If a safe radial stress can be determined for cortical bone in a particular patient, the associated implantation force, and pull‐out force which represents primary stability, can be directly derived, regardless of implantation direction, bone quality or implant surface. Radial implantation delivers primary stability that is no worse than that for axial implantation and may eliminate potentially damaging impaction forces. Development of implant designs based on this principal might improve implant fixation. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:224–233, 2017.
Improving the emulsifying properties of β‐lactoglobulin–wild almond gum (Amygdalus scoparia Spach) exudate complexes by heat
Authors: Golkar Abdolkhalegh , Nasirpour Ali , Keramat Javad 
Published: April 2016

AbstractBACKGROUNDThe present study aims to investigate the advantageous effects of wet heating, BLG (β‐lactoglobulin)/Ang (Angum gum) ratio, and pH (normal pH of mixed BLG and Ang solutions, pHc > pH > pHΦ1) on the emulsifying properties of wet‐heated β‐lactoglobulin–wild almond gum exudate (Amygdalus scoparia Spach) mixture over those of electrostatic counterparts.RESULTSCovalent linkage of BLG‐Ang conjugates was confirmed by SDS‐PAGE and FTIR analysis. Emulsion activity (EA), emulsion stability (ES), and droplet size characteristics of emulsions were significantly (P < 0.05 and P < 0.01) affected by electrostatic/wet‐heating, biopolymer ratio, pH, and their interactions. The electrostatic complexes with pHc > pH > pHΦ1 exhibited higher EA and ES values for all the biopolymer ratios investigated than their electrostatic counterparts with pH after mixing. However, these values for the wet‐heated samples at pH after mixing were found to be higher than those of the samples subjected to heat treatment at pHc > pH > pHΦ1. Based on the results obtained, it was concluded that E/1:2/3.80 and W/1:2/6.69 were the two complexes with finer droplet size distributions after preparation (26.72 ± 3.71 and 15.27 ± 1.01 µm, respectively) and after one week of storage at 4 °C (30.71 ± 1.57 and 28.79 ± 0.56 µm, respectively) than others. Apparent viscosities of electrostatic and wet‐heated complexes and emulsions made with the complexes were measured.CONCLUSIONProtein–polysaccharide interactions can be used as an efficient way for producing novel emulsifiers/stabilisers after heat treatment. © 2016 Society of Chemical Industry