bluuebunny/crossref_metadata_2025_split huggingface dataset:
Borrelia Lymphocytoma Mimicking Butterfly Rash in a Pediatric Patient
Authors: Llamas-Velasco Mar , Paredes Bruno Emilio 
Published: September 2017

Abstract:
A 5-year-old girl presented with a facial butterfly rash that persisted for 5 months without arthralgia, fever, malaise, photosensitivity, or other symptoms. Lupus erythematosus was clinically suspected. All blood tests were negative or within normal values. Skin biopsy showed a dense nodular superficial and deep inflammatory infiltrate of lymphocytes that reaches subcutaneous tissue. The most striking histopathological finding was plasma cells with some perifollicular accentuation. Borrelia polymerase chain reaction assay of the tissue was positive, and we made the diagnoses of borrelia lymphocytoma mimicking butterfly rash of lupus erythematosus. The lesions disappeared with amoxicillin followed by cefuroxime for 28 days. In children, a variety of diseases including lupus erythematous may lead to a butterfly rash that is usually short lasting and commonly associated with systemic symptoms. Borreliosis may be related with long-lasting facial erythema in children and may mimic lupus and present high titers of antinuclear antibodies. In any case, borrelial lymphocytoma has not been previously reported as a cause of butterfly rash, thus mimicking acute lupus in a child, as in our case. From a histopathological point of view, the presence of plasma cells in a pseudolymphomatous infiltrate is a clue for the right diagnosis. Therefore, we suggest that borrelia serology should be done in children with butterfly rash lasting more than a month and empirical antibiotic treatment should be tried even in cases with negative serology.
Comparison of Transperianal Ultrasound With Colonoscopy and Magnetic Resonance Imaging in Perianal Crohn Disease
Authors: Lee Eun Hye , Yang Hye Ran , Kim Ji Young 
Published: September 2017

ABSTRACTObjective:Perianal fistulae and/or abscesses are common complications of Crohn disease (CD), especially in children. Magnetic resonance imaging (MRI) and gross examination under anesthesia are accurate diagnostic modalities for evaluating perianal lesions. Both methods, however, are expensive and have some limitations for use in children. This study aims to assess the accuracy of transperianal ultrasound (TPUS) and colonoscopic examination, compared with MRI, in pediatric patients with perianal CD (PACD).Methods:Thirty‐eight children and adolescents with PACD who underwent MRI, TPUS, and gross colonoscopic examination under sedation were included. Fistulae were classified according to Parks’ and St. James's University Hospital classifications. Abscesses were identified by their presence and location on each modality.Results:Fifty‐nine fistulae (26 superficial, 23 intersphincteric, 10 transsphincteric) and 16 abscesses were detected using MRI. Fifty‐nine fistulae and 10 abscesses were detected using TPUS. Forty‐five fistulae (sensitivity 76.3%, positive predictive value [PPV] 84.2%, and kappa value 0.296] and 9 abscesses (sensitivity 56.3%, PPV 90.0%, and kappa value 0.624) on TPUS corresponded with MRI findings. Forty‐six fistulae and fifteen abscesses were detected using colonoscopy. Forty fistulae (sensitivity 67.8%, PPV 89.9%, and kappa value 0.369) and 7 abscesses (sensitivity 43.8%, PPV 48.8%, and kappa value 0.304) on colonoscopy corresponded with MRI findings. With respect to abscess, agreement between TPUS and MRI was superior to that between colonoscopy and MRI (Spearman rho 0.651 vs 0.304, P = 0.007).Conclusion:TPUS is an appropriate, simple, and real‐time method for detecting perianal fistula and/or abscess, in children with PACD.
Neonatal Exposure to Hepatitis C Virus Antigens in Uninfected Children Born to Infected Mothers
Authors: Psaros Einberg Afrodite , Brenndörfer Erwin Daniel , Frelin Lars , Hallberg Lena , Sällberg Matti , Fischler Björn 
Published: September 2017

ABSTRACTObjective:Vertical transmission of hepatitis C virus (HCV) infection is uncommon and occurs in approximately 5% of births from HCV‐infected mothers. The reason for the low transmission rate is unclear. We aimed to investigate whether there is evidence of HCV exposure also in the noninfected children born to HCV‐infected mothers by the presence of a detectable immune response.Methods:Serum and peripheral blood mononuclear cells from 9 HCV vertically infected children, 32 uninfected children born to HCV infected mothers, and 15 HCV chronically infected mothers, were analyzed. HCV‐RNA‐negative adults and children were used as controls. HCV‐specific T cell responses were analyzed by interferon gamma using an enzyme‐linked immunospot assay and 3H‐thymidine incorporation assay. HCV antibodies were also analyzed.Results:An HCV‐specific T cell response was detected in 73% (11/15) of the HCV‐infected mothers, 67% (6/9) of the vertically infected children, 56% (18/32) of the exposed but uninfected children and in 10% and 20% of the control groups, respectively. The 2 groups of HCV‐exposed children both had a significantly higher proportion of HCV‐specific T cell responders compared to pediatric controls (P = 0.01 and P = 0.02).Conclusions:HCV‐specific immune responses were more common in children born to HCV‐infected mothers, regardless of the presence of HCV RNA. We conclude that noninfected children born to HCV‐infected mothers may have been exposed to HCV antigens.
A Teenager With Sickle Cell Disease and Scalp Swelling
Authors: Nelson Courtney E. , Scarfone Richard J. 
Published: September 2017

Abstract
An intracranial bleed with a midline shift is a potentially life-threatening clinical condition. We present the unusual case of a 13-year-old boy with sickle cell disease who had numerous emergency department visits for a scalp hematoma and was subsequently determined to have subdural and epidural hematomas with midline shift, associated with a skull bone infarction. We review the pathophysiology of this unusual condition and emphasize the importance of including it in the differential diagnosis of any child with sickle cell anemia presenting with a nontraumatic scalp hematoma.
Intervening in Interruptions: What Exactly Is the Risk We Are Trying to Manage?
Authors: Gao Jonathan , Rae Andrew John , Dekker Sidney W.A. 
Published: September 2017

Abstract
Interruptions are thought to be significantly associated with medication administration errors. Researchers have tried to reduce medication errors by decreasing or eliminating interruptions. In this article, we argue that interventions are often (perhaps unreflectively) based on one particular model of risk reduction—that of barriers placed between the source of risk and the object-to-be-protected. Well-intentioned interventions can lead to unanticipated effects because the assumptions created by the risk model are not critically examined. In this article, we review the barrier model and the assumptions it makes about risk and risk reduction/prevention, as well as the model’s incompatibility with work in healthcare. We consider how these problems lead to interruptions interventions with unintended negative consequences. Then, we examine possible alternatives, viz organizing work for high reliability, preventing safety drift, and engineering resilience into the work activity. These all approach risks in different ways, and as such, propose interruptions interventions that are vastly different from interventions based on the barrier model. The purpose of this article is to encourage a different approach for designing interruptions interventions. Such reflection may help healthcare communities innovate beyond old, ineffective, and often counterproductive interventions to handle interruptions.
Laparoscopic Surgery for Large Gastric Submucosal Tumors
Authors: Takahashi Kodai , Kanehira Eiji , Kamei Aya , Tanida Takashi , Sasaki Kazunori 
Published: September 2017

Background:
In general, laparoscopic resection for gastric gastrointestinal stromal tumors (GISTs) >5 cm is not recommended. However, there is a lack of evidence to support this recommendation.

Patients and Methods:
This study included 108 patients who underwent laparoscopic surgery for gastric GISTs. Of the 108 patients, 23 had GISTs>5 cm. The aim of this study is to evaluate the oncological safety of laparoscopic surgery for large gastric GISTs. In addition, we performed a rapid systematic review of laparoscopic surgery for large gastric GISTs.

Results:
In our cases, all patients were performed R0 resection without capsular rupture and surgical margins were negative on pathologic examination. In all studies, en bloc resection was achieved without capsular rupture in all patients. The average positive surgical margins rate was 1.6% in total reports.

Conclusions:
The laparoscopic approach for large gastric GISTs>5 cm has been proposed as safe when performed by experienced surgeons.
Twelve-Month Efficacy and Safety Data for the “Stress Incontinence Control, Efficacy and Safety Study”: A Phase III, Multicenter, Prospective, Randomized, Controlled Study Treating Female Stress Urinary Incontinence Using the Vesair Intravesical Balloon
Authors: Winkler Harvey , Jacoby Karny , Kalota Susan , Snyder Jeffrey , Cline Kevin , Robertson Kaiser , Kahan Randall , Green Lonny , McCammon Kurt , Rovner Eric , Rardin Charles 
Published: September 2017

Objectives
The “Stress Incontinence Control, Efficacy and Safety Study” (SUCCESS) is a phase III study of the Vesair Balloon in women with stress urinary incontinence who had failed conservative therapy, and either failed surgery, were not candidates for surgery, or chose not to have surgery. The safety and efficacy of the balloon at 12 months is reported for those participants in the treatment arm who elected to continue with the SUCCESS trial beyond the primary end point at 3 months.

Methods
The SUCCESS trial is a multicenter, prospective, single-blinded, randomized, sham-controlled study. Participants were randomized on a 2.33:1 basis to either Vesair Balloon placement or placebo. The primary efficacy end point was a composite of both a greater than 50% reduction from baseline on 1-hour provocative pad weight test and an at least 10-point improvement in symptoms on the Incontinence Quality of Life questionnaire assessed at the 3-month study visit. Patients in the treatment arm who opted to continue in the trial were followed up prospectively up to 12 months.

Results
A total of 221 participants were randomized, including 157 in the treatment arm and 64 in the control arm. Sixty-seven participants in the treatment arm (42.7% of participants enrolled) were evaluated at 12 months, with 56.3% achieving the composite end point and 78.7% having greater than 50% reduction in pad weight from baseline in a per-protocol analysis. In an intent-to-treat analysis treating all participants who did not continue with the balloon as failures, 24% of the participants achieved the composite end point and 33.6% had a greater than 50% reduction in pad weight from baseline. Treatment-related adverse events in this group included dysuria (40.1%), gross hematuria (36.9%), and urinary tract infection (26.1%).

Conclusions
In this phase III trial, symptom relief was maintained for those participants who continued therapy for 12 months. The balloon was found to be safe with no device- or procedure-related serious adverse events reported. Additional studies are warranted to determine which patient populations are more tolerant of the balloon and to assess the efficacy and safety of its longer-term use. Additional screening methods, including screening patients for balloon tolerability, are warranted to reduce participant withdrawals.
Health Literacy in Women Presenting to a Urogynecology Practice
Authors: Sripad Abhishek A. , Rupp Betty M. , Gage Jessica L. , Feliciano Katherine M. , Willis-Gray Marcella , Wu Jennifer M. 
Published: September 2017

Objective
Health literacy (HL) is the degree to which an individual can obtain, process, and communicate basic health information to make appropriate health decisions. Understanding HL of patients can improve outcomes. Thus, we evaluated HL in women with pelvic floor disorders and investigated its relationship to patient demographics, reading level, and cognition.

Methods
We conducted a cross-sectional study with a convenience sample of English-speaking women 18 years or older, recruited from female pelvic medicine and reconstructive surgery clinics from July 2016 to January 1, 2017. Patients with severe visual impairment or severe cognitive impairment were excluded. We used the reading comprehension passages of the short form of Test of Functional Health Literacy in Adults to assess HL, the reading subscale of the Wide Range Achievement Test 3 for reading level, and the Self-administered Gerocognitive Exam for cognition.

Results
Among 196 participants, the mean age was 61.1 ± 13.3 years, 84.7% were white, and 54.1% were college educated. Most participants (95.4%) demonstrated adequate HL. Those with adequate HL were younger (60.5 ± 13.2 vs 71.8 ± 10.7, P = 0.01), had less cognitive impairment (12.5% vs 77.8%, P < 0.001), and more frequently had post–high school reading levels (70.1% vs 33.3%, P < 0.001).

Conclusions
Overall HL in the pelvic floor disorder population is high, but older patients with cognitive impairment and lower reading levels are at risk of inadequate HL. Lowering reading levels of educational materials and screening for cognitive impairment may be beneficial to patient understanding and health outcomes.
Perimenstrual Exacerbation of Symptoms in Borderline Personality Disorder: Evidence from Multilevel Models and the Carolina Premenstrual Assessment Scoring System
Authors: Eisenlohr-Moul Tory A. , Schmalenberger Katja M. , Owens Sarah A. , Peters Jessica R. , Dawson Danyelle N. , Girdler Susan S. 
Published: September 2017

AbstractBackgroundIndividuals with borderline personality disorder (BPD) suffer from a constellation of rapidly shifting emotional, interpersonal, and behavioral symptoms. The menstrual cycle may contribute to symptom instability among females with this disorder.MethodsFifteen healthy, unmedicated females with BPD and without dysmenorrhea reported daily symptoms across 35 days. Urine luteinizing hormone (LH) and salivary progesterone (P4) were used to confirm ovulation and cycle phase. Cyclical worsening of symptoms was evaluated using (1) phase contrasts in multilevel models and (2) the Carolina Premenstrual Assessment Scoring System (C-PASS; Eisenlohr-Moul et al., 2017b), a protocol for evaluating clinically significant cycle effects on symptoms.ResultsMost symptoms demonstrated midluteal worsening, a perimenstrual peak, and resolution of symptoms in the follicular or ovulatory phase. Post-hoc correlations with person-centered progesterone revealed negative correlations with most symptoms. Depressive symptoms showed an unexpected delayed pattern in which baseline levels of symptoms were observed in the ovulatory and midluteal phases, and exacerbations were observed during both the perimenstrual and follicular phases. The majority of participants met C-PASS criteria for clinically significant (>=30%) symptom exacerbation. All participants met the emotional instability criterion of BPD, and no participant met DSM-5 criteria for premenstrual dysphoric disorder (PMDD).ConclusionsFemales with BPD may be at elevated risk for perimenstrual worsening of emotional symptoms. Longitudinal studies with fine-grained hormonal measurement as well as hormonal experiments are needed to determine the pathophysiology of perimenstrual exacerbation in BPD.
Daily activity and visual discrimination reflects the eye organization of weaver antOecophylla smaragdina(Insecta: Hymenoptera: Formicidae)
Authors: Mishra Monalisa , Bhadani Snigdha 
Published: September 2017

AbstractThe currently studied antOecophylla smaragdinais arboreal in nature. It shows unique property in terms of its nest building behavior using leaves of the tree. The ant uses its eye to locate the food and nest. Eye types vary among ants living in the different habitat. In this context, the structure of the eye, daily activity and the foraging behaviour ofO. smaragdinaare missing from the literature. For the first time, the current study discovers: (1) the antO. smaragdinaforage in fully lighted condition. (2)The eye structure shows that the eye is adapted to a diurnal lifestyle.(3) The daily activity is proportional to the temperature of the surroundings. The study significantly correlates the role of vision in the foraging behaviour ofO. smaragdina. The daily activity is further associated with the surrounding light and ambient temperature. The current study uncovers the structure of the eye and eye-related behaviour of the animal not described in earlier studies.
Interphase Human Chromosome Exhibits Out of Equilibrium Glassy Dynamics
Authors: Shi Guang , Liu Lei , Hyeon Changbong , Thirumalai D. 
Published: September 2017

AbstractThe structural organization of the condensed chromosomes is being revealed using chromosome conformation capture experiments and super-resolution imaging techniques. Fingerprints of their three-dimensional organization on length scale from about hundred kilo base pairs to millions of base pairs have emerged using advances in Hi-C and super-resolution microscopy. To determine the poorly understood dynamics of human interphase chromosomes, we created the Chromosome Copolymer Model (CCM) by representing the chromosomes as a self-avoiding polymer with two loci types corresponding to euchromatin and heterochromatin. Using advanced clustering algorithms we establish quantitatively that the simulated contact maps for chromosomes 5 and 10 and those inferred from Hi-C experiments are in agreement. Ward Linkage Matrix (WLM), constructed from spatial distance information, shows that the Topologically Associated Domains (TADs) and compartments predicted from simulations are in agreement with inferred WLM computed using data from super-resolution microscopy experiments. Glassy dynamics is manifested in the stretched exponential relaxation of the structure factor and caging in the mean square displacement of individual loci, ∆i(t) ∼tαwith 0 <α< 1. Remarkably, the distribution ofα, is extremely broad suggestive of highly heterogeneous dynamics, which is also reflected in the large cell-to-cell variations in the contact maps. Chromosome organization is hierarchical involving the formation of chromosome droplets (CDs) on short genomic scale followed by coalescence of the CDs, reminiscent of Ostwald ripening. We propose that glassy landscapes for the condensed active chromosomes might provide a balance between genomic conformational stability and biological functions.
Nanomechanical Analysis of Extracellular Matrix and Cells in Multicellular Spheroids
Authors: Vyas Varun , Solomon Melani , D’Souza Gerard G.M. , Huey Bryan D. 
Published: September 2017

AbstractNanomechanical investigation with Atomic Force Microscope has revealed new details regarding various nanomechanical heterogeneities for cells that are embedded in extracellular matrix in Multicellular spheroidal culture. This investigation sheds new insight into dynamic relationship of cells with their surrounding environment in tumors and 3D multicellular cultures.Nanotechnology has revolutionized the field of cancer biology and has opened new avenues towards understanding nanomechanical variations in rapidly growing tumors. Over the last decade Atomic Force Microscope (AFM) has played an important role in understanding nanomechanical properties of various cancer cell lines. This study is focused on Lewis Lung Carcinoma Cell (LLC) tumors as 3D multicellular spheroid (MS). Such multicellular structures have enabled investigation of various components of tumors in-vitro. To better comprehend mechanical properties of cells and its surrounding extracellular matrix (ECM), depth dependent indentation measurements were conducted with Atomic Force Microscope (AFM). Force-vs-indentation curves were used to create stiffness profiles as function of depth. Here studies were focused on outer most layer i.e. proliferation zone of the spheroid. AFM investigations of sample a MS revealed three nanomechanical topographies, Type A- high modulus due to collagen stress fibers, Type B- high stiffness at cell membrane & ECM interface and Type C - increased modulus due to cell lying deep inside matrix at the a depth of 1.35 microns. Various nanomechanical heterogeneities revealed in this investigation can shed new light in developing correct dosage regime for various tumor dissolving drugs and designing more controlled artificial extracellular matrix systems for replicating tissue growth in-vitro.Short Statistical SummaryThis article describes nanomechanical characteristics of the cells embedded in extracellular matrix in a multicellular spheroid. The paper contains 6350 words including title page and references. Graphical Content contains 46 words. This article contains 6 Figures and zero tables.
Proteomic Characterization of the Venom Of FiveBombus (Thoracobombus)Species
Authors: Barkan Nezahat Pinar , Bayazit Mustafa Bilal , Demiralp Özel Duygu 
Published: September 2017

AbstractVenomous animals use venom; a complex biofluid composed of unique mixtures of proteins and peptides, to act on vital systems of the prey or predator. In bees, venom is solely used for defense against predators. However, the venom composition of bumble bees (Bombus sp.) is largely unknown.Thoracobombussubgenus ofBombus sp.is a diverse subgenus represented by 14 members across Turkey. In this study, we sought out to proteomically characterize the venom of fiveThoracobombusspecies by using bottom-up proteomic techniques. We have obtained two-dimensional polyacrylamide gel (2D-PAGE) images of each venom sample. We have subsequently identified the protein spots by using matrix assisted laser desorption ionization / time of flight mass spectrometry (MALDI-TOF MS). We have identified 47 proteins forBombus humilis; 32 forB. pascuorum, 60 forB. ruderarius; 39 forB. sylvarumand 35 forB. zonatus. Our analyses provide the primary proteomic characterization of five bumble bee species’ venom composition.
QuiXoT: quantification and statistics of high-throughput proteomics by stable isotope labelling
Authors: Trevisan-Herraz Marco , Jorge Inmaculada , Bonzon-Kulichenko Elena , Navarro Pedro , Vázquez Jesús 
Published: September 2017

Abstract:In most software tools for quantification of mass spectrometry-based proteomics by stable isotope labelling (SIL), there is a recurrent disconnection between the use of a statistical model and convenient data visualisation to check correct data modelling. Most of them lack a robust statistical framework, using models which do not account for the major difficulties in proteomics, such as the unbalanced peptide-protein distribution, undersampling, or the correct separation of sources of variance. This makes especially difficult the interpretation of quantitative proteomics experiments. Here we present QuiXoT, an extensively tested quantification and statistics open source software based on a robust and extensively validated statistical model, the WSPP (weighted spectrum, peptide, and protein). Its associated software package allows the user to visually represent and inspect results at all modelled levels (scan, peptide and protein) on routine bases. It is applicable to practically any SIL method (SILAC, iTRAQ, and18O among others) or MS instrument.