bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory focus theory and sustainable entrepreneurship
Authors: Fischer Denise , Mauer René , Brettel Malte 
Published: June 2017

PurposeThe purpose of this paper is to examine the role of regulatory focus in sustainable entrepreneurship processes to answer questions on how sustainable entrepreneurs pursue their goals and what motivates them. Knowledge about an entrepreneur’s motivational attribute is essential when trying to understand new venture creation processes. To determine an entrepreneur’s affiliation with one of the two self-regulatory systems, promotion focus and prevention focus, it is helpful to establish whether he or she is motivated by growth and development goals (promotion) or rather by responsibility and security goals (prevention).Design/methodology/approachIn a qualitative study of seven sustainable ventures, two semi-structured interview rounds with 14 founders were conducted. Archival data from internal and external sources were gathered, resulting in more than 80 text documents.FindingsFindings reveal that the self-regulatory focus of sustainable entrepreneurs changes during the entrepreneurial process with regard to the temporal dynamics of motivation. While conceiving ideas, sustainable entrepreneurs engage in a prevention-focused self-regulatory process because social or ecological problems induce them to direct their attention toward sustainable development goals. During rollout, in contrast, they increasingly engage in a promotion-focused self-regulatory process and concentrate more on venture growth goals.Practical implicationsThe results highlight the important role of a regulatory fit between key self-regulatory entrepreneurial behaviors and entrepreneurs’ regulatory orientation toward increased motivation and enjoyment when pursuing goals.Originality/valueThis study’s contributions extend and combine the theories of regulatory focus, entrepreneurial motivation, and entrepreneurial processes in the field of sustainable entrepreneurship. They are valuable for understanding the determinants of sustainable entrepreneurial action.
Does eWOM matter to brand extension?
Authors: Liu Xin , Hu Jing , Xu Bing 
Published: June 2017

Purpose
The purpose of this study is to find out how electronic word of mouth (eWOM) may affect evaluations of products with different brand images. In particular, the study explores differential eWOM impacts across several brand types and extension categories.

Design/methodology/approach
An experiment with 2 (brand image: prestige/function) × 2 (category similarity: low/high) × 2 (eWOM message type: positive/negative) between-subjects design was used to examine the impacts of eWOM on different types of brand extensions. A total of 268 subjects from a public university in the Southwest participated in the study. Analysis of Variance (ANOVA) was used in analyzing the data.

Findings
The findings highlight the differential impact of eWOM on brand extension evaluations with different brand images. First, eWOM is more effective in influencing evaluations of functional brand extensions than prestige brand extensions. Second, whereas negative eWOM does equally bad on both high- and low-similarity brand extensions, positive eWOM is more effective in improving evaluations of high-similarity extensions than low-similarity extensions.

Originality/value
This study is the first to examine the impact of eWOM on products with different brand images. This is a critical issue for brand managers who allocate limited marketing resources to monitoring and managing vast amounts of eWOM activities. The findings provide important guidance for managing social media marketing communications.
Personality determinants of need for interaction with a retail employee and its impact on self-service technology (SST) usage intentions
Authors: Lee Hyun-Joo 
Published: June 2017

Purpose
The purpose of this study was, first, to link interpersonal-hedonic values, intuitive-experiential thinking style, external locus of control (LOC) and sociability to the need for interaction with a retail employee; and, second, to empirically test the moderating effect of the time convenience of self-service technologies (SSTs) on the proposed relationships in the model.

Design/methodology/approach
This study was conducted in a retail setting in which an automated checkout process occurred with the use of self-checkout systems. A self-administered, online survey approach was utilized targeting consumer panel members. Data were analyzed using structural equation modeling.

Findings
Interpersonal-hedonic values, external LOC and sociability emerged as reliable antecedents of the need for interaction with a retail employee, whereas the intuitive-experiential thinking style did not. This study also showed the inverse relationship between the need for interaction with a retail employee and the intentions to use SSTs. In relation to the moderating role of the time convenience of SSTs, the positive effects of interpersonal-hedonic values, intuitive-experiential thinking style, external LOC and sociability on the need for interaction with a retail employee were shown lesser for consumers with low levels of the time convenience of SSTs. The negative effect of the need for interaction with a retail employee on the intentions to use SSTs was shown to be greater for consumers with low levels of the time convenience of SSTs.

Originality/value
The present study adds to a growing body of literature on SSTs by exploring the causal and hierarchical effects of personality traits that determine the intentions to use SSTs.
Exploring the role of website quality and hedonism in the formation of e-satisfaction and e-loyalty
Authors: Ahmad Asad , Rahman Obaidur , Khan Mohammed Naved 
Published: June 2017

PurposeThe purpose of this study is to explore the factors that help in building e-loyalty towards online retailers. Internet has brought the world market into a single platform. Marketers have started using Internet as a new and innovative way to interact and reach people all around the world. With the increase in the number of Internet users, the number of e-marketers has also increased. In the context of online retailing, the service quality being offered is increasingly being used as a tool for competitive advantage. E-tailers are embracing superior e-services to attract, retain and convert patrons into loyal customers.Design/methodology/approachThe researchers in the present study have used a research instrument that consists of constructs of the modified eTailQ scale, hedonism and e-satisfaction that together result in the formation of e-loyalty. Researcher-controlled sampling was employed to collect data from 159 student respondents.FindingsExploratory factor analysis, confirmatory factor analysis and structural equation modelling were applied for analysing the collected data. The results of the study demonstrate that major factors which help in the formation of e-loyalty are e-satisfaction, customer service, privacy and hedonism.Originality/valueThis study extends the understanding of the role of e-satisfaction, customer service, privacy and hedonism in the formation of loyal consumers. The researchers proposed a model to study the factors impacting the e-loyalty of the Internet shoppers in India. The findings of the study are expected to help both researchers and marketers.
Determinant Factors of Satisfaction with Public Services in Spain
Authors: Alemán Roxana , Gutiérrez‐Sánchez Ramón , Liébana‐Cabanillas Francisco 
Published: June 2017

AbstractThe concept of marketing has evolved significantly, as have its applications in various sectors, including services. Diverse opinions have been expressed for and against the use of marketing techniques in public administration. In this paper, we present a conceptual and methodological review of the main contributions made by marketing to the public sector, measuring variables and related concepts that determine public satisfaction with public services. These elements, termed key drivers of opinion, were measured by reference to the information provided by the Spanish Sociological Research Centre (CIS), and provide an alternative way to display and analyse the data of interest, through perception models and figures using multivariate factor analysis. In this study, the components or factors containing the main drivers of opinion were found to be, on the one hand, commitment to efficient service, and on the other, user convenience.
Saving Republics by Moving Republicans: Britain, Ireland and ‘New Geneva’ During the Age of Revolutions
Authors: WHATMORE RICHARD 
Published: June 2017

AbstractIn 1783 the British and Irish governments launched an experiment by funding the establishment of a settlement that was expected to become a new city. It was called ‘New Geneva’ and was situated on the site of a village called Passage, just outside the port of Waterford in Ireland. New Geneva was to be peopled by rebels, Genevans who had fled or were ready to flee in the aftermath of the failed revolution of 1782. This article explains that for the main Genevan actors in the Waterford experiment, François d'Ivernois (Sir Francis d'Ivernois from 1796) and his friend Jacques‐Antoine Du Roveray, the exodus from Geneva was part of a greater battle to save Europe's small states, and especially the republics of Europe. The article further reveals that the major supporters of New Geneva were seeking to address Britain's problems both domestically and as an empire. Charles Stanhope, then Lord Mahon (from 1786 3rd earl of Stanhope), and William Petty, then 2nd earl of Shelburne (from 1784 1st marquess of Lansdowne), each hoped that the Genevans would introduce cultures capable of palliating the excessive corruption or ‘mercantile system’ they saw in Britain's commercial society. The history of New Geneva underscored the perilous state of Europe's republics before 1789, the widespread extent of the view that Britain and Ireland were in crisis, and the fact that extreme and cosmopolitan reform projects were in the air before the French Revolution.
The Religious ‘Persecutions’ in the Grand Duchy of Tuscany and British Sympathy for Italian Nationalism, 1851–1853
Authors: WRIGHT O. J. 
Published: June 2017

AbstractThe history of British relations with the states of pre‐unification Italy is a neglected field of enquiry. The research that has been undertaken has tended to focus on the generally good relationship Britain shared with the Kingdom of Sardinia, the state which presided over Italy's national unification between 1859 and 1861. By contrast, the extent to which Britain's poor relations with the Papal States, the Kingdom of the Two Sicilies and the Grand Duchy of Tuscany, and the impact that negative perceptions of those countries had upon the development of British sympathy for Italian nationalism, are little understood. This article on British reactions to what the Victorians perceived as religious ‘persecutions’ in the Grand Duchy of Tuscany begins to redress this imbalance. Tuscany was in many respects one of the more progressive states in the Italian peninsula. Its government was moderate compared with those at Naples and Rome, it was affluent and it invested in a modern communications infrastructure. However, during the years following the revolutionary upheaval of 1848–9, the Tuscan state's policy of religious retrenchment led to a sequence of events – some of which involved British subjects – which were perceived as examples of religious ‘persecution’ in Victorian Britain. British reactions to these events illustrate the extent to which religion could affect British foreign policy during the mid‐nineteenth century, and they help to explain the emergence of British sympathy for the Italian nationalist cause during the 1850s.
Reproductive endocrine issues in men with sickle cell anemia
Authors: Huang A. W. , Muneyyirci‐Delale O. 
Published: June 2017

SummaryIn patients with sickle cell anemia, the sickling of red blood cells is known to cause end‐organ damage by infarction. In some men who are affected by sickle cell anemia, the obstruction of venous outflow of the penis causes priapism, which could lead to erectile dysfunction. There is also evidence that the disease is linked to other reproductive issues in men—specifically delayed puberty, low testosterone, and sperm abnormalities—although the causes of these problems are less clear. Treatment of sickle cell anemia can have effects on the reproductive system as well. This review summarizes the findings from various publications pertaining to reproductive endocrinology, along with their conclusions and discrepancies.
Randomised clinical trial: sofosbuvir and ledipasvir in patients with transfusion‐dependent thalassaemia and HCV genotype 1 or 4 infection
Authors: Mangia A. , Sarli R. , Gamberini R. , Piga A. , Cenderello G. , Piazzolla V. , Santoro R. , Caruso V. , Quarta A. , Ganga R. , Copetti M. , Forni G. 
Published: June 2017

SummaryBackgroundPatients with thalassaemia major depend on blood transfusions. In Italy, up to 80% of thalassaemia patients bear HCV antibodies due to HCV contaminated transfusions before 1990. Thalassaemia patients with HCV infection have high risk of developing HCC. Treatment based on Pegylated‐IFN (Peg‐IFN) and Ribavirin (RBV) was limited by relevant side effects.AimTo evaluate the impact of Sofosbuvir/Ledipasvir (SOF/LDV) fixed dose combination for 12 weeks without RBV, in patients with thalassaemia major and HCV Genotype 1 or 4 (GT1/4).MethodsOpen label, historically‐controlled, nationwide multicentre study in thalassaemia patients including naïve with cirrhosis and prior treatment failure without cirrhosis. SOF/LDV single pill was administered for 12 weeks to 100 patients of whom 16% had cirrhosis. The control group included 96 patients with comparable baseline characteristics treated with Peg‐IFN/RBV. The primary end point was sustained virologic response at follow‐up week 12 or 24 after IFN‐free or Peg‐IFN/RBV, respectively.ResultsIn the study group, sustained virological response (SVR) was reported in 98% of patients (95% CI 95.3%‐100%). Cirrhotic as well as prior treatment failure achieved 100% SVR. In the control group, SVR was 47.9% (95% CI 37.9%‐57.9%). Adverse events including fatigue, headache, nausea, decrease in haemoglobin or increase in ferritin levels were rare and significantly less common in the study than in the historical control group.ConclusionsIn conclusion, SOF/LDV for 12 weeks provides simple, highly effective and safe Peg‐IFN/RBV‐free treatment for HCV GT1/4 thalassaemia patients. EUDRACT number 2015‐002401‐1.
Comparative safety of pioglitazone versus clinically meaningful treatment alternatives concerning the risk of bladder cancer in older US adults with type 2 diabetes
Authors: Garry Elizabeth M. , Buse John B. , Lund Jennifer L. , Pate Virginia , Stürmer Til 
Published: June 2017

AimsTo compare bladder cancer incidence between patients initiating pioglitazone treatment and patients initiating treatment with dipeptidyl‐peptidase‐4 inhibitors [DPP‐4s] or sulfonylureas.MethodsWe identified Medicare beneficiaries aged >65 years who initiated treatment with pioglitazone (N = 38 700), DPP‐4s (N = 82 552) or sulfonylureas (N = 126 104) between 2007 and 2014 after at least 6 months without prescriptions for these drug classes. Patients were followed from second prescription until bladder cancer outcome (2 claims within 60 days) using a 6‐month induction/latency period, censoring for treatment change, death or end of 2014. We used propensity score‐weighted Cox proportional‐hazards models to obtain adjusted hazard ratios (aHR) and their 95% confidence intervals.ResultsOverall mean age of participants was 75 years and 41% were men. Over a median of 1.2 treatment years, 727 beneficiaries developed bladder cancer. Pioglitazone initiators had an increased incidence of bladder cancer (308 vs 204 [DPP‐4s] or 231 [sulfonylureas] per 100 000 person‐years; aHR, 1.57 [1.23‐2.00] vs DPP‐4s and 1.32 [1.02‐1.70] vs sulfonylureas). The increased risk emerged within the first 2 years of treatment (aHR, 1.63 [1.22‐2.17] vs DPP‐4s and 1.32 [0.98‐1.78] vs sulfonylureas). If treatment was discontinued within the first 2 years, the risk after 2 years post initiation was attenuated (aHR, 0.89 [0.61‐1.28]) compared with patients treated for more than 2 years (aHR, 1.45 [0.93‐2.26]) both vs DPP‐4s. Findings were consistent across secondary and sensitivity analyses.ConclusionsPioglitazone was associated with an elevated risk of bladder cancer compared with DPP‐4s and sulfonylureas. The elevated risk emerged within the first 2 years of treatment and was attenuated after discontinuing. Pioglitazone's relative effectiveness should be weighed against a small absolute increase in risk of bladder cancer.
Self‐administration of methamphetamine alters gut biomarkers of toxicity
Authors: Flack Amanda , Persons Amanda L. , Kousik Sharanya M. , Celeste Napier T. , Moszczynska Anna 
Published: June 2017

AbstractMethamphetamine (METH) is a highly abused psychostimulant that is associated with an increased risk for developing Parkinson's disease (PD). This enhanced vulnerability likely relates to the toxic effects of METH that overlap with PD pathology, for example, aberrant functioning of α‐synuclein and parkin. In PD, peripheral factors are thought to contribute to central nervous system (CNS) degeneration. For example, α‐synuclein levels in the enteric nervous system (ENS) are elevated, and this precedes the onset of motor symptoms. It remains unclear whether neurons of the ENS, particularly catecholaminergic neurons, exhibit signs of METH‐induced toxicity as seen in the CNS. The aim of this study was to determine whether self‐administered METH altered the levels of α‐synuclein, parkin, tyrosine hydroxylase (TH), and dopamine‐β‐hydroxylase (DβH) in the myenteric plexus of the distal colon ENS. Young adult male Sprague‐Dawley rats self‐administered METH for 3 h per day for 14 days and controls were saline‐yoked. Distal colon tissue was collected at 1, 14, or 56 days after the last operant session. Levels of α‐synuclein were increased, while levels of parkin, TH, and DβH were decreased in the myenteric plexus in the METH‐exposed rats at 1 day following the last operant session and returned to the control levels after 14 or 56 days of forced abstinence. The changes were not confined to neurofilament‐positive neurons. These results suggest that colon biomarkers may provide early indications of METH‐induced neurotoxicity, particularly in young chronic METH users who may be more susceptible to progression to PD later in life.
The posterior thigh flap for defect coverage of ischial pressure sores – a critical single‐centre analysis
Authors: Djedovic Gabriel , Morandi Evi M , Metzler Julia , Wirthmann Anna , Matiasek Johannes , Bauer Thomas , Rieger Ulrich M 
Published: June 2017

ABSTRACTThe development of pressure sores is still not only an enormous economical but also a medical burden. Especially in the ischial region, the local defect coverage remains demanding as it is the main weight‐bearing area in wheelchair‐mobilised patients and is prone to high mobility. The purpose of our study was to report our long‐time experience with the reconstruction of ischial pressure ulcers with the medially based posterior thigh flap.A retrospective analysis of all primary pressure sores grade III–IV in the ischial area, which were covered with a medially based posterior thigh flap between January 2008 and December 2014, at our department was conducted.A total of 28 patients underwent defect coverage of an ischial pressure sore with the aforementioned flap. The subgroup with complications showed a statistically significant longer hospital stay. A statistically significant correlation between age and the coincidence of comorbidities could be seen. Older patients showed significantly higher grades of pressure sores.The medially based posterior thigh flap is a safe and reliable flap design. Complication rates are comparable to other flaps. Nevertheless, in case of complications, a significantly longer duration of hospitalisation has to be taken into account.
Effects of white light‐emitting diode (LED) exposure on retinal pigment epithelium in vivo
Authors: Jaadane Imene , Villalpando Rodriguez Gloria Elisa , Boulenguez Pierre , Chahory Sabine , Carré Samuel , Savoldelli Michèle , Jonet Laurent , Behar‐Cohen Francine , Martinsons Christophe , Torriglia Alicia 
Published: June 2017

AbstractAgeing and alteration of the functions of the retinal pigment epithelium (RPE) are at the origin of lost of vision seen in age‐related macular degeneration (AMD). The RPE is known to be vulnerable to high‐energy blue light. The white light‐emitting diodes (LED) commercially available have relatively high content of blue light, a feature that suggest that they could be deleterious for this retinal cell layer. The aim of our study was to investigate the effects of “white LED” exposure on RPE. For this, commercially available white LEDs were used for exposure experiments on Wistar rats. Immunohistochemical stain on RPE flat mount, transmission electron microscopy and Western blot were used to exam the RPE. LED‐induced RPE damage was evaluated by studying oxidative stress, stress response pathways and cell death pathways as well as the integrity of the outer blood–retinal barrier (BRB). We show that white LED light caused structural alterations leading to the disruption of the outer blood–retinal barrier. We observed an increase in oxidized molecules, disturbance of basal autophagy and cell death by necrosis. We conclude that white LEDs induced strong damages in rat RPE characterized by the breakdown of the BRB and the induction of necrotic cell death.
Age, Emotion Regulation, and Affect in Adulthood: The Mediating Role of Cognitive Reappraisal
Authors: Nakagawa Takeshi , Gondo Yasuyuki , Ishioka Yoshiko , Masui Yukie 
Published: June 2017

AbstractEvidence indicates that older adults experience high levels of emotional well‐being. However, little is known empirically about the underlying mechanism of this state. The purpose of the present study was to investigate whether emotion regulation mediates the link between age and affect in adulthood. The sample consisted of 516 Japanese participants aged 30 (±1), 50 (±1), and 70 (±1) years, who were registered with an Internet survey company. Cognitive reappraisal and expressive suppression were measured as emotion regulation strategies. Positive and negative affect were assessed. Older participants reported lower negative affect than younger participants, while positive affect was not correlated with age. Cognitive reappraisal partially mediated the relationship between age and affect, whereas expressive suppression did not. The results suggested that age‐related increase in cognitive reappraisal could contribute to improvements in affect, but that another adaptive form of emotion regulation may mediate the relationship between age and affect. Our study thus indicates that developments in emotion regulation could explain the mechanism of stable everyday affect throughout adulthood, and that researchers should further explore another form of adaptive emotion regulation.