bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: TRIAZOLO(4,5‐D)PYRIMIDINES. III. THE TRANSFORMATION OF 3‐SUBSTITUTED 3H‐1,2,3‐TRIAZOLO(4,5‐D)PYRIMIDINES INTO 3‐SUBSTITUTED 3H‐1,2,3‐TRIAZOLO(4,5‐B)PYRIDINES
Authors: HIGASHINO T. , KATORI T. , HAYASHI E. 
Published: April 2016

AbstractDie Triazolopyrimidine (I) hydrolysieren in verdünnter Schwefelsäure langsam zu Aminotriazol‐carbaldehyden, die mit den CH‐aciden Carbonylverbindungen (II) zu den Triazolopyridinen (III) kondensieren.
ChemInform Abstract: SYNTHESIS OF LIN‐BENZOALLOPURINOL
Authors: FOSTER R. H. , LEONARD N. J. 
Published: April 2016

AbstractAus dem Toluidin (I) entsteht die Nitroverbindung (IIa), die zum Nitril (IIb) austauscht und dann zum Diamin‐amid (III) reduziert und hydrolysiert werden kann.
ChemInform Abstract: STUDIES OF HIGHLY STRAINED HETEROCYCLES. 4. THE REACTIONS OF 1,2‐DIPHENYL‐1‐AZASPIRO(2.2)PENTANE AND 2‐PHENYL‐1‐AZASPIRO(2.2)PENT‐1‐ENE WITH C,N‐DIARYLNITRILIMINES
Authors: TSUGE O. , WATANABE H. , KIRYU Y. 
Published: April 2016

AbstractDie Umsetzung des stark gespannten Azaspiropentans (I) mit den in situ (aus den entsprechenden N‐(a‐Chlorbenzylidem‐N′‐phenylhydrazinen und Et3N in CHCl3 oder Benzol) erzeugten QN‐Diarylnitriliminen (II) ist stark von den Reaktionsbedingungen abhängig und kann zu den Verbindungen (III)‐(VII) führen (s. Schema).
ChemInform Abstract: ISOTHIOCYANATES. I. ADDITION OF UREA TO AROYL ISOTHIOCYANATES AND CONVERSION OF THE MONOADDUCTS INTO MONOTHIOBIURET, 4‐THIOXO‐1,3,5‐TRIAZIN‐2‐ONES AND 1,2,4‐THIADIAZOL‐3‐ONES
Authors: BASYOUNI M. N. , EL‐KHAMRY A.‐M. 
Published: April 2016

AbstractDie bisher unbekannten Thiobiurete (III) werden durch Addition von Harnstoff (I) an die Isothiocyanate (II) dargestellt.
ChemInform Abstract: β‐OXOSULFENYL CHLORIDES ‐ A NEW SYNTHESIS OF 5,6‐DIHYDRO‐4H‐1,2,4‐THIADIAZINES
Authors: MUEHLSTAEDT M. + , MEINHOLD H. , SEELE T. 
Published: April 2016

AbstractDie Sulfenylchloride (I) werden mit den Amidinen (II) in basischem Milieu zu den Thiadiazinen (III) kondensiert.
ChemInform Abstract: N‐SUBSTITUTED 2,2′‐DIPHENIC ACID IMIDES
Authors: ELSHAFIE S. M. M. 
Published: April 2016

AbstractUmsetzen von Diphensäureanhy diid (I) mit den Aminen (II) liefert die N‐substituierten Imide (III), die mit P2S5 in die Dithione (IV) übergeführt werden.
ChemInform Abstract: CHEMISTRY OF BORON. CIV. NEW RING SYSTEMS CONTAINING DIBORON UNITS AS RING MEMBERS: DITHIADISILABORACYCLOPENTANES, DITHIATRIBOROLANES, AND DITHIATETRABORINANES
Authors: NOETH H. + , FUSSSTETTER H. , POMMERENING H. , TAEGER T. 
Published: April 2016

AbstractDie mit Pyridin katalysierte Reaktion zwischen dem Cyclothiasilan (I) und dem Dithiatetrasilacyclohexan (II) liefert das Dithiatrisilacyclopentan (III).
ChemInform Abstract: CUMULATED YLIDES. VI. A NEW SYNTHESIS OF (TRIPHENYLPHOSPHORANYLIDENE)KETENE, ITS THIO ANALOG, AND STABLE PROPADIENYLIDENETRIPHENYLPHOSPHORANES
Authors: BESTMANN H. J. , SANDMEIER D. 
Published: April 2016

AbstractDie Einwirkung von Na‐bis‐[trimethylsilyl]‐amid auf die P‐Ylide (I), für die die Grenzstrukturen A und Bangegeben werden, führt unter β‐Eliminierung zu dem Phosphoranylidenketen bzw. ‐thioketen (II) mit den Grenzstrukturen A und B. Die analoge Reaktion von Na‐bis‐[trimethylsilyH‐amid mit den (oz‐Ethoxyallyliden)‐triphenylphosphoranen (III), dargestellt aus (2,2‐Diethoxyvinyliden)‐triphenylphosphoran und entsprechenden CH‐aciden Verbindungen durch Michael‐Addition und anschließende Ethanolabspaltung, liefert die stabilen Propadienyliden‐triphenylphosphorane (IV), für die ebenfalls Grenzstrukturen diskutiert werden.
ChemInform Abstract: OPTICALLY ACTIVE ESTERS OF THIOARSINOUS ACIDS. SYNTHESIS, PROPERTIES, AND SOME STEREOSPECIFIC REACTIONS
Authors: IONOV L. B. , KOROVJAKOV A. P. , CHERNOKAL'SKII B. D. 
Published: April 2016

AbstractBei der Einwirkung von Alkylmercaptanen (II) auf Alkylphenyl‐chlorarsine (I) in Anwesenheit der optisch‐aktiven Verbindung (III) läßt sich eine asymmetrische Synthese der Alkylester der Alkylphenyl‐thioarsinigsäure (IV) durchführen.
ChemInform Abstract: TRIS(2‐PYRIDYL)PHOSPHINE COMPLEXES OF RUTHENIUM(II) AND RHODIUM(I). HYDROFORMYLATION OF HEX‐1‐ENE BY RHODIUM COMPLEXES
Authors: KURTEV K. , RIBOLA D. , JONES R. A. , COLE‐HAMILTON D. J. , WILKINSON G. 
Published: April 2016

AbstractDie Ru(II)‐ und Rh(I)‐Komplexe (I)‐(V) werden meist durch Substitutionsreaktionen ihrer Triphenylphosphin‐Analogen mit dem aus 2‐Brompyridin durch Lithiierung und Umsetzung mit PCl3 synthetisierten Titelliganden (Ausb. 60%) erhalten.
ChemInform Abstract: FORMATION OF ZWITTERIONIC CHELATING LIGANDS DURING INSERTION REACTIONS OF CARBON DISULFIDE INTO PALLADIUM‐PHOSPHORUS AND PALLADIUM‐HYDROGEN BONDS
Authors: WERNER H. , BERTLEFF W. 
Published: April 2016

AbstractCS2 reagiert mit dem Komplex (I) unter Einlagerung in die Pd‐Me‐Bindung zu dem Dithioacetat‐Komplex (II).
ChemInform Abstract: CAROTENOIDS OF RHIZOBIA. IV. ISOLATION AND STRUCTURE ELUCIDATION OF THE CAROTENOIDS OF A MUTANT OF RHIZOBIUM LUPINI
Authors: BEYER P. , KLEINIG H. , ENGLERT G. , MEISTER W. , NOACK K. 
Published: April 2016

AbstractAufgrund spektroskopischer (UV (Sichtbar), MS, 1H‐NMR) Untersuchungen wurden für die aus dem Mutant 1‐207 von Rhizobium lupini isolierten Pigmente die Strukturen (Ia) (ßß‐Carotin), (Ib) (Echinenon), (Ic) (Canthaxanthin), (Id) ((3S)‐3‐Hydroxy‐echinenon), (Ie), (If) ((3S)‐Adonirubin), und (Ig)‐(Ij) ermittelt.
ChemInform Abstract: SYNTHESIS OF 7,8‐EPOXY‐7,8‐DIHYDRORETINOIDS
Authors: DAVALLIAN D. , HEATHCOCK C. H. 
Published: April 2016

AbstractVinylmagnesiumbromid (II) reagiert mit dem Aldehyd (I) zu einem Carbinol (III), das mit HBr zum Bromid (IVa) und weiter mit Triethylphosphjt zum Phosphonat (IVb) reagiert.
ChemInform Abstract: SYNTHESIS OF CERTAIN β‐D‐RIBOFURANOSYL THIAZOLE C‐NUCLEOSIDES FROM A VERSATILE PRECURSOR
Authors: COUSINEAU T. J. , SECRIST J. A. III 
Published: April 2016

AbstractDer aus D‐Ribose in bekannter Weise zugängliche Ester (Ia) wird zum Aldehyd (Ib) reduziert der allerdings nicht zu (Ic) bromiert werden konnte.
ChemInform Abstract: SYNTHESIS OF (.+‐.)‐MACHICENDIOL
Authors: SCHNEIDERS G. E. , STEVENSON R. 
Published: April 2016

AbstractAus dem Bromvanillin (I) und dem Cu‐acetylid (II) entsteht das Benzofuran (III), das tert.‐Butyllithioacetat zum Carbinol (IV) addiert und dann zum Machicendiol (Va) reduziert werden kann.
Impact Electrochemistry: Detection of Graphene Nanosheets Labeled with Metal Nanoparticles through Oxygen Reduction Mediation
Authors: Thearle Rozi Alice , Sofer Zdeněk , Bouša Daniel , Pumera Martin 
Published: April 2016

AbstractWe have prepared Pt/Fe‐ and Fe‐nanoparticle‐labeled graphene sheets and demonstrate that these sheets can be detected by using impact electrochemistry through oxygen reduction mediation.
Variability in subjective review of umbilical cord blood colony forming unit assay
Authors: Powell K. , Kwee E. , Nutter B. , Herderick E. , Paul P. , Thut D. , Boehm C. , Muschler G. 
Published: April 2016

BackgroundThe goal of this study was to quantitatively evaluate the reproducibility of current manual counting methods of colony forming units (CFUs) from umbilical cord blood samplesMethodsFresh and reconstituted frozen cells from 10 cord blood samples were cultured under standard conditions. The number of BFU‐Es, CFU‐GMs, and CFU‐GEMMs were counted by three expert reviewers using the standard microscope method and manually traced CFUs on digital images of cell cultures.ResultsThe mean colony count based on the traced digital images was 82 (22% CV) and 52 (15% CV) for the fresh and frozen samples, respectively. This was significantly greater than that observed using the microscope, 61 (13% CV) for fresh and 43 (16% CV) for frozen. The difference was mainly due to the reviewers observing more CFU‐GMs in the digital images than through the microscope review. All three reviewers agreed on the presence of a colony 72% of the time based on the digital review in both fresh and frozen samples. Reviewer agreement with respect to colony type in the fresh samples was 38% (22%CV), 25% (51%CV), and 6% (115%CV) for BFU‐Es, CFU‐GMs, and CFU‐GEMMs, respectively. Reviewer agreement increased for BFU‐Es and CFU‐GMs in the frozen samples where fewer colonies were present.ConclusionsAlthough this study showed marked variability between reviewers, the analysis of manually traced digital images has the potential to improve inter‐observer variation when compared to current methods by identifying features that lead to discrepancies in colony counting and providing cases with consensus results. © 2016 International Clinical Cytometry Society
In vitro evaluation of human endometrial stem cell‐derived osteoblast‐like cells’ behavior on gelatin/collagen/bioglass nanofibers’ scaffolds
Authors: Sharifi Esmaeel , Ebrahimi‐Barough Somayeh , Panahi Maryam , Azami Mahmoud , Ai Arman , Barabadi Zahra , Kajbafzadeh Abdol‐Mohammad , Ai Jafar 
Published: April 2016

AbstractNew biomimetic nanocomposite scaffold was prepared by the combination of nanofibrilar bioglass containing copper ion as the inorganic phase and gelatin/collagen as the organic phase of bone tissue. In this study for fabrication of the scaffold, freeze drying and electrospinning methods were used, and genipin was used as the cross‐linking agent for increasing the mechanical properties of the scaffold. The growth and viability of human endometrial stem cell‐derived osteoblast‐like cells were investigated on this biomimetic scaffold. Cellular biocompatibility assays illustrated that this scaffold has more viabilities and osteoblast growths in comparison with two‐dimensional culture. Copper ion increased growth of the osteoblasts on nanocomposite scaffold containing nanofibrous bioglass. Thus, the results obtained from this study indicate that the prepared scaffold is suitable for osteoblast growth and attachment; thus, potentially, this nanocomposite scaffold is an appropriate scaffold for bone tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2210–2219, 2016.
Quantifying shape changes of silicone breast implants in a murine model using in vivo micro‐CT
Authors: Anderson Emily E. , Perilli Egon , Carati Colin J. , Reynolds Karen J. 
Published: April 2016

AbstractA major complication of silicone breast implants is the formation of a capsule around the implant known as capsular contracture which results in the distortion of the implant. Recently, a mouse model for studying capsular contracture was examined using micro‐computed tomography (micro‐CT), however, only qualitative changes were reported. The aim of this study was to develop a quantitative method for comparing the shape changes of silicone implants using in vivo micro‐CT. Mice were bilaterally implanted with silicone implants and underwent ionizing radiation to induce capsular contracture. On day 28 post‐surgery mice were examined in vivo using micro‐CT. The reconstructed cross‐section images were visually inspected to identify distortion. Measurements were taken in 2D and 3D to quantify the shape of the implants in the normal (n = 11) and distorted (n = 5) groups. The degree of anisotropy was significantly higher in the distorted implants in the transaxial view (0.99 vs. 1.19, p = 0.002) and the y‐axis lengths were significantly shorter in the sagittal (9.27 mm vs. 8.55 mm, p = 0.015) and coronal (9.24 mm vs. 8.76 mm, p = 0.031) views, indicating a deviation from the circular cross‐section and shortening of the long axis. The 3D analysis revealed a significantly lower average thickness (sphere‐fitting method) in distorted implants (6.86 mm vs. 5.49 mm, p = 0.002), whereas the volume and surface area did not show significant changes. Statistically significant differences between normal and distorted implants were found in 2D and 3D using distance measurements performed via micro‐CT. This objective analysis method can be useful for a range of studies involving deformable implants using in vivo micro‐CT. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1447–1452, 2017.
Comparison Between an Automated and Manual Extraction for the Determination of Immunosuppressive Drugs Whole Blood Concentrations by Liquid Chromatography Tandem Mass Spectrometry
Authors: Deslandes Guillaume , Grégoire Matthieu , Renaud Christian , Monteil‐Ganière Catherine , Azoulay Claudine , Pineau Alain , Jolliet Pascale , Dailly Eric 
Published: April 2016

BackgroundThe whole blood extraction for liquid chromatography tandem mass spectrometry (LC‐MS/MS) of simultaneous quantification of cyclosporine A (Cys A), tacrolimus (Tacrs), sirolimus (Siros), and everolimus (Evers) is still performed manually in many laboratories. The analytical results obtained with an automated method using a liquid handler versus a classical manual preparation were compared.MethodsCys A (n = 36), Tacrs (n = 50), Siros (n = 34), Evers (n = 38) whole blood samples of patients were analyzed by LC‐MS/MS assay after manual preparation and automated process using a liquid handling platform including a centrifugation step.ResultsThe comparison between manual and automated extraction investigated by a linear regression showed a high correlation between results [(Tacrs “automated”) = 1.0927 × (Tacrs “manual”) − 0.36; (Cys A “automated”) = 1.0284 × (Cys A “manual”) + 0.0312; (Siros “automated”) = 0.9923 × (Siros “manual”) + 0.4001; (Evers “automated”) = 1.0000 × (Evers “manual”) − 0.0600].ConclusionThe results obtained by the automated and manual preparation are consistent. The automated method is applied for high‐throughput therapeutic drug monitoring of immunosuppressive drugs in routine practice, leading to an increase in quality.
Dental histology of Coelophysis bauri and the evolution of tooth attachment tissues in early dinosaurs
Authors: Fong Raymond K.M. , LeBlanc Aaron R.H. , Berman David S. , Reisz Robert R. 
Published: April 2016

ABSTRACTStudies of dinosaur teeth have focused primarily on external crown morphology and thus, use shed or in situ tooth crowns, and are limited to the enamel and dentine dental tissues. As a result, the full suites of periodontal tissues that attach teeth to the jaws remain poorly documented, particularly in early dinosaurs. These tissues are an integral part of the tooth and thus essential to a more complete understanding of dental anatomy, development, and evolution in dinosaurs. To identify the tooth attachment tissues in early dinosaurs, histological thin sections were prepared from the maxilla and dentary of a partial skull of the early theropod Coelophysis bauri from the Upper Triassic (Rhaetian‐ 209–201 Ma) Whitaker Quarry, New Mexico, USA. As one of the phylogenetically and geologically oldest dinosaurs, it is an ideal candidate for examining dental tissues near the base of the dinosaurian clade. The teeth of C. bauri exhibited a fibrous tooth attachment in which the teeth possessed five tissues: enamel, dentine, cementum, periodontal ligament (PDL), and alveolar bone. Our findings, coupled with those of more recent studies of ornithischian teeth, indicate that a tripartite periodontium, similar to that of crocodilians and mammals, is the plesiomorphic condition for dinosaurs. The occurrence of a tripartite periodontium in dinosaurs adds to the growing consensus that the presence of these tissues is the plesiomorphic condition for the major amniote clades. Furthermore, this study establishes the relative timing of tissue development and growth directions of periodontal tissues and provides the first comparative framework for future studies of dinosaur periodontal development, tooth replacement, and histology. J. Morphol. 277:916–924, 2016. © 2016 Wiley Periodicals, Inc.
Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis
Authors: Chang Jiun C. , Sebastian Aimy , Murugesh Deepa K. , Hatsell Sarah , Economides Aris N. , Christiansen Blaine A. , Loots Gabriela G. 
Published: April 2016

ABSTRACTJoint injury causes post‐traumatic osteoarthritis (PTOA). About ∼50% of patients rupturing their anterior cruciate ligament (ACL) will develop PTOA within 1–2 decades of the injury, yet the mechanisms responsible for the development of PTOA after joint injury are not well understood. In this study, we examined whole joint gene expression by RNA sequencing (RNAseq) at 1 day, 1‐, 6‐, and 12 weeks post injury, in a non‐invasive tibial compression (TC) overload mouse model of PTOA that mimics ACL rupture in humans. We identified 1446 genes differentially regulated between injured and contralateral joints. This includes known regulators of osteoarthritis such as MMP3, FN1, and COMP, and several new genes including Suco, Sorcs2, and Medag. We also identified 18 long noncoding RNAs that are differentially expressed in the injured joints. By comparing our data to gene expression data generated using the surgical destabilization of the medial meniscus (DMM) PTOA model, we identified several common genes and shared mechanisms. Our study highlights several differences between these two models and suggests that the TC model may be a more rapidly progressing model of PTOA. This study provides the first account of gene expression changes associated with PTOA development and progression in a TC model. © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. J Orthop Res 35:474–485, 2017.
Prospective evaluation of skin and nipple‐areola sensation and patient satisfaction after nipple‐sparing mastectomy
Authors: Dossett Lesly A. , Lowe Janell , Sun Weihong , Lee M.C. , Smith Paul D. , Jacobsen Paul B. , Laronga Christine 
Published: April 2016

BackgroundSensation and quality of life (QOL) before and after nipple sparing mastectomy (NSM) are poorly understood.MethodsWomen electing mastectomy with immediate reconstruction and eligible for NSM were prospectively enrolled in a sensation and satisfaction/QOL study. Women self‐selected skin‐sparing mastectomy (SSM) or NSM. Skin sensation testing using Semmes Weinstein monofilaments and patient satisfaction/QOL surveys were administered preoperatively and at 1 year postoperatively.Results53 patients were enrolled (n = 38, 72% NSM and n = 15, 28% SSM). Both groups had significant reduction in postoperative skin sensation. For NSM, measurable NAC sensation was preserved in both NAC for 26% of patients and in one NAC for 68%. QOL and satisfaction was similar between groups. Neither group was satisfied with sexual arousal with breast or nipple stimulation after surgery.ConclusionPatients undergoing SSM and NSM have considerable loss in skin and NAC sensation following surgery. Satisfaction and QOL did not differ between groups. J. Surg. Oncol. 2016;114:11–16. © 2016 Wiley Periodicals, Inc.
Spaceborne laser filamentation for atmospheric remote sensing
Authors: Dicaire I. , Jukna V. , Praz C. , Milián C. , Summerer L. , Couairon A. 
Published: April 2016

AbstractA proof‐of‐concept of space‐borne laser filamentation for atmospheric remote sensing is presented. The remote generation of laser filaments from an Earth‐orbiting satellite is shown by numerical simulations to be theoretically possible for a large range of laser parameters. The model includes a realistic representation of the stratified atmosphere and accounts for multi‐species ionization and the dependence of air density upon the molecule type and altitude profile. The remote generation of a white light continuum extending from 350 nm to 1.1 μm within the filament is demonstrated, and hereby proposed as an atmospheric in‐situ light source for monitoring greenhouse gases and pollutants on a global scale by light detection and ranging (lidar) techniques. Scaling laws are also derived for estimating the filament altitude as a function of peak pulse power (3 GW‐3 TW), beam radii (10‐200 cm) and for three different curvatures (300, 390, 500 km) for femtosecond infrared (800 nm) pulses. We find that operating conditions for remote supercontinuum generation are already available with current ground‐based mobile laser technology and within reach of future space laser systems.
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Approximation schemes for single‐machine scheduling with a fixed maintenance activity to minimize the total amount of late work
Authors: Yin Yunqiang , Xu Jianyou , Cheng T. C. E. , Wu Chin‐Chia , Wang Du‐Juan 
Published: April 2016

AbstractWe consider the problem of scheduling n independent and simultaneously available jobs without preemption on a single machine, where the machine has a fixed maintenance activity. The objective is to find the optimal job sequence to minimize the total amount of late work, where the late work of a job is the amount of processing of the job that is performed after its due date. We first discuss the approximability of the problem. We then develop two pseudo‐polynomial dynamic programming algorithms and a fully polynomial‐time approximation scheme for the problem. Finally, we conduct extensive numerical studies to evaluate the performance of the proposed algorithms. © 2016 Wiley Periodicals, Inc. Naval Research Logistics 63: 172–183, 2016
Prescription Monitoring Program Trends Among Individuals Arrested in Maine for Trafficking Prescription Drugs in 2014
Authors: McCall Kenneth , Nichols Stephanie D. , Holt Christina , Ochs Leslie , Cattabriga Gary , Tu Chunhao 
Published: April 2016

ObjectiveTo evaluate controlled substance prescribing trends available in the Maine Prescription Monitoring Program (PMP) among individuals arrested for prescription drug “trafficking.” The demographic characteristics of the individuals who had matching prescription records in the PMP within 90 days of the arrest were identified.Study DesignA population‐based, retrospective cohort study using data from the Maine Diversion Alert Program (DAP) and the Maine PMP. The study population consisted of persons arrested for trafficking prescription drugs in Maine during the 2014 calendar year from January 1 to December 31.ResultsThere were 594 trafficking arrests reported by the Maine DAP in 2014. The study population consisted of the 235 persons (40%) with arrests involving controlled prescription medications. The mean age of these persons was 33 years (range 18–77 yrs), and 156 (66%) were male. Arrests involved 154 prescription opioids (65%), seven stimulants (3%), seven benzodiazepines (3%), and 77 unspecified controlled prescription drugs (33%). A minority of individuals (n=57, 24%) had a prescription record in the PMP that matched the substance involved in the arrest. Only one person with matching PMP and arrest records utilized ≥ 5 prescribers, while none used ≥ 5 pharmacies within 90 days before the arrest. Payment methods for matching prescriptions were commercial insurance (n=28, 49%), Medicaid (n=19, 33%), Medicare (n=5, 9%), and cash (n=5, 9%).ConclusionsThe majority (76%) of persons arrested for prescription drug trafficking did not have PMP records and did not directly obtain the diverted medication from a licensed pharmacy. Traditional red flags, like cash payment and using multiple prescribers or pharmacies, were uncommon. Therefore, arrest records for diversion and PMPs are distinct and complementary tools for identifying individuals at risk for substance misuse.