bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimierte Beleuchtung im Bode‐Museum Berlin
Authors: Kaase Heinrich , Aydınlı Sırrı , Gramm Stefan 
Published: December 2015

AbstractDie Optimierung der Museumsbeleuchtung basiert auf der gleichzeitigen Berücksichtigung energetischer, beleuchtungstechnischer, farbmetrischer und konservatorischer Aspekte, die sich auf den ersten Blick unter Umständen widersprechen. Am Beispiel des Berliner “Bode‐Museums“ konnte gezeigt werden, dass der Ersatz der bisher verwendeten HGL‐ durch LED‐Leuchten eine Reduzierung des Energieumsatzes um bis zu 70 % ermöglicht. Im gedimmten Betrieb kann sich dieser Wert aufgrund der besser geeigneten Dimmkennlinie der LEDs noch weiter erhöhen. Gleichzeitig ist mit einer verringerten Objektschädigung durch UV‐ und kurzwellige sichtbare Strahlung und deutlich verringerter thermischer Belastung der Objekte durch IR‐Strahlung zu rechnen. Außerdem ermöglicht die Kombination verschiedener LEDs in einer Leuchte eine variable Lichtfarbe mit sehr guter Farbwiedergabe. Bei der Auswahl der LED‐Lösungen ist eine Abwägung der konservatorischen Anforderungen unerlässlich, als einfachstes Bewertungskriterium kann dabei die ähnlichste Farbtemperatur herangezogen werden. Werden alle diese Gesichtspunkte berücksichtigt, ermöglicht die LED‐Technik erstmals die Kombination einer energieeffizienten verbesserten Beleuchtung bei gleichzeitig verbessertem Objektschutz.Optimized lighting for the Bode‐Museum in Berlin. The optimization of museum lighting is based on energetic, luminous, colorimetric and conservation aspects, which seems to contradict each other in part. As an example the energy expenditure of the illumination of the “Bode‐Museum” could be reduced by up to 70 % when replacing conventional HGL‐ by LED‐luminaires. In dimmed mode, this value may increase even further due to a more appropriate dimming characteristic of LED. This is accompanied by a reduced damage by UV radiation and short wavelength part of the visible radiation and at the same time without thermal loading of objects by IR radiation. In addition, the combination of different LED in one luminaire creates a variable luminous colour with very good colour rendering properties. The consideration of the conservation requirements is essential when choosing the correct LED‐lighting, for a simple evaluation criterion the correlated colour temperature can be used. If all these aspects are taken into account, the LED technology enables the combination of enhanced energy‐efficient lighting with improved preservation requirements.
Residential agricultural pesticide exposures and risks of selected birth defects among offspring in the San Joaquin Valley of California
Authors: Carmichael Suzan L. , Yang Wei , Roberts Eric , Kegley Susan E. , Brown Timothy J. , English Paul B. , Lammer Edward J. , Shaw Gary M. 
Published: December 2015

BackgroundWe examined associations of birth defects with residential proximity to commercial agricultural pesticide applications in California. Subjects included 367 cases representing five types of birth defects and 785 nonmalformed controls born 1997 to 2006.MethodsAssociations with any versus no exposure to physicochemical groups of pesticides and specific chemicals were assessed using logistic regression adjusted for covariates. Overall, 46% of cases and 38% of controls were classified as exposed to pesticides within a 500 m radius of mother's address during a 3‐month periconceptional window.ResultsWe estimated odds ratios (ORs) for 85 groups and 95 chemicals with five or more exposed cases and control mothers. Ninety‐five percent confidence intervals (CI) excluded 1.0 for 11 ORs for groups and 22 ORs for chemicals, ranging from 1.9 to 3.1 for groups and 1.8 to 4.9 for chemicals except for two that were <1 (noted below).ConclusionFor groups, these ORs were for anotia/microtia (n = 95 cases) and dichlorophenoxy acids/esters and neonicotinoids; anorectal atresia/stenosis (n = 77) and alcohol/ethers and organophosphates (these ORs were < 1.0); transverse limb deficiencies (n = 59) and dichlorophenoxy acids/esters, petroleum derivatives, and triazines; and craniosynostosis (n = 79) and alcohol/ethers, avermectins, neonicotinoids, and organophosphates. For chemicals, ORs were: anotia/microtia and five pesticides from the groups dichlorophenoxy acids/esters, copper‐containing compounds, neonicotinoids, organophosphates, and triazines; transverse limb deficiency and six pesticides – oxyfluorfen and pesticides from the groups copper‐containing compounds, 2,6‐dinitroanilines, neonicotinoids, petroleum derivatives and polyalkyloxy compounds; craniosynostosis and 10 pesticides – oxyfluorfen and pesticides from the groups alcohol/ethers, avermectins, n‐methyl‐carbamates, neonicotinoids, ogranophosphates (two chemicals), polyalkyloxy compounds (two chemicals), and pyrethroids; and congenital diaphragmatic hernia (n = 62) and a copper‐containing compound. Birth Defects Research (Part A) 106:27–35, 2016. © 2015 Wiley Periodicals, Inc.
High doses of alcohol during pregnancy cause DNA damages in osteoblasts of newborns rats
Authors: Carvalho Isabel Chaves Silva , Dutra Tamires Pereira , De Andrade Dennia Perez , Balducci Ivan , Pacheco‐Soares Cristina , Rocha Rosilene Fernandes da 
Published: December 2015

BackgroundAlcohol exerts teratogenic effects and its consumption during pregnancy can cause deficit of bone development. The aim of the current study was to evaluate the genotoxic effects of prenatal exposure to ethanol on newborn rat osteoblasts.MethodsWistar rats were initially divided into two groups: Ethanol group which received Ethanol 20% V/V in liquid diet and solid diet ad libitum, and Control group, which received solid diet and water ad libitum. Each group received a specific diet for 8 weeks before breeding and throughout three weeks of gestation and the treatment was finished on the day the pups were killed. On the fifth day of life, the pups from each group were killed for removal of the calvaria and isolation of osteogenic cells by sequential enzymatic digestion. The cells were cultured for a maximum period of 14 days. The detection of genotoxic effects of alcohol was investigated by the comet and the micronucleus assay.ResultsMicronucleus and comet assay showed significant increases in DNA damage at 7 days in Ethanol group (p = 0.0302, p = 0.0446, respectively). However, at 14 days both assay showed no significant difference between the groups (p = 0.6194, p = 0.8326, respectively).ConclusionOur results showed that prenatal exposure to ethanol induced DNA damage in osteoblasts, as shown by micronucleus formation and higher percentage of DNA in the comet tail. It can be concluded that prenatal exposure to ethanol damages osteoblast DNA in newborns exposed to high doses of ethanol during pregnancy, suggesting that prenatal ethanol consumption has a direct effect on fetal osteoblasts. Birth Defects Research (Part A) 106:122–132, 2016. © 2015 Wiley Periodicals, Inc.
Hospitalization charges for children with birth defects in Texas, 2001 to 2010
Authors: Moffitt Karen B. , Case Amy P. , Farag Noha H. , Canfield Mark A. 
Published: December 2015

BackgroundState‐specific information about hospitalizations of children with birth defects can improve understanding of changes in occurrence, treatment practices, and health care financing policies. This study analyzed aggregated data on hospital charges and length of stay for a large, diverse population.MethodsWe extracted hospitalization data for children diagnosed with birth defects from the Texas Hospital Inpatient Discharge Public Use Data File (2001−2010). Analyses compared total charges and length of stay for children with and without a diagnosis code of any birth defect among 45 standard categories. We also examined trends for total charges by expected payer type.ResultsIn Texas, 431,296 hospital stays were reported for children with birth defects, with total charges of $24.8 billion. Mean hospital stay for children with birth defects was more than twice that of those without, whereas mean of hospital total charges was approximately six times greater. Pyloric stenosis accounted for the largest number of hospitalizations, followed by certain cardiac defects. Pediatric hospitalizations for birth defects increased 273.7%, compared with a 214.7% increase overall. The percentage of charges with Medicaid as expected payer (2004–2010) ranged from 56.5 to 62.0%.ConclusionCharges associated with these conditions are far greater than those associated with pediatric hospitalizations for other causes, whether in the newborn period or beyond. However, these charges vary depending on specific diagnoses, expected payer source, and year of treatment. Birth Defects Research (Part A) 106:155–163, 2016. © 2015 Wiley Periodicals, Inc.
Acardiac twinning: High resolution three‐dimensional reconstruction of a low resistance case
Authors: van Lier Monique G.J.T.B. , Lopriore Enrico , Vandenbussche Frank P.H.A. , Streekstra Geert J. , Siebes Maria , Nikkels Peter G.J. , Oepkes Dick , van Gemert Martin J.C. , van den Wijngaard Jeroen P.H.M. 
Published: December 2015

BackgroundAcardiac twinning is a rare anomaly of monochorionic twin pregnancies. Acardiac fetuses lack a functional heart but are passively perfused by arterial blood from their pump co‐twin. Although four acardiac morphological types have been classified, the various paths of anatomical and circulatory acardiac twin development, and the potential influence of acardiac size and perfusion flow as possible predictors of pump twin morbidity and mortality are poorly understood. This report presents the first high resolution three‐dimensional reconstruction of the vasculature of an acardiac twin by cryomicrotome imaging.CaseA small, approximately 7.5‐cm‐diameter ball‐shaped acardius amorphous of 30 5/7 weeks had caused pump twin cardiac decompensation that necessitated an emergency cesarian section. The pump twin survived well. The acardiac body had a partially intact vascular system with large diameter arteries and veins and multiple zones that appeared devoid of perfusion. The three‐dimensional reconstruction showed neither recognizable organ structures nor identifiable blood vessels except for the umbilical artery and vein.ConclusionOur case showed a small acardiac mass with large diameter vessels and consequential low outflow resistance that caused pump twin complications. This indicates that the development of a method that allows pump twin prognosis is likely more successful if based on the use of acardiac versus pump twin perfusion flows than on body volume ratios. Birth Defects Research (Part A) 106:213–217, 2016. © 2015 Wiley Periodicals, Inc.
Two decades of axillary management in breast cancer
Authors: Beek M A , Verheuvel N C , Luiten E J T , Klompenhouwer E G , Rutten H J T , Roumen R M H , Gobardhan P D , Voogd A C 
Published: December 2015

Abstract

Background
Axillary lymph node dissection (ALND) in patients with breast cancer provides prognostic information. For many years, positive nodes were the most important indication for adjuvant systemic therapy. It was also believed that regional control could not be achieved without axillary clearance in a positive axilla. However, during the past 20 years the treatment and staging of the axilla has undergone many changes. This large population-based study was conducted in the south-east of the Netherlands to evaluate the changing patterns of care regarding the axilla, including the introduction of sentinel lymph node biopsy (SLNB) in the late 1990s, implementation of the results of the American College of Surgeons Oncology Group Z0011 study, and the initial effects of the European Organization for Research and Treatment of Cancer AMAROS study.

Methods
Data from the population-based Eindhoven Cancer Registry of all women diagnosed with invasive breast cancer in the south of the Netherlands between January 1993 and July 2014 were used.

Results
The proportion of 34 037 women staged by SLNB without completion ALND increased from 0 per cent in 1993–1994 to 69·0 per cent in 2013–2014. In the same period the proportion undergoing ALND decreased from 88·8 to 18·7 per cent. Among women with one to three positive lymph nodes, the proportion undergoing SLNB alone increased from 10·6 per cent in 2011–2012 to 37·6 per cent in 2013–2014.

Conclusion
This population-based study demonstrated the radical transformation in management of the axilla since the introduction of SLNB and following the recent publication of trials on management of the axilla with a low metastatic burden.
An exercise on hardware/software codesign following the RISC model
Authors: Joseph Diya , Kaur Geetika , Chakraborty Pinaki 
Published: December 2015

ABSTRACTThis paper presents an exercise to demonstrate the benefits of hardware/software codesign. A RISC processor and a high‐level language have been designed together to make best use of the features of one another. A CPU simulator, an assembler and a compiler have been implemented based on the design. The exercise is suitable for students of computer engineering and electronics engineering students nearing their graduation. © 2015 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:305–312, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21711
Physician experiences and preferences in the treatment of HR+/HER2− metastatic breast cancer in the United States: a physician survey
Authors: Lin Peggy L. , Hao Yanni , Xie Jipan , Li Nanxin , Zhong Yichen , Zhou Zhou , Signorovitch James E. , Wu Eric Q. 
Published: December 2015

AbstractSequential endocrine therapy (ET) is recommended for postmenopausal women with hormone receptor‐positive (HR+)/human epidermal growth factor receptor 2‐negative (HER2−) metastatic breast cancer (mBC) and without visceral symptoms. Chemotherapy (CT) can be considered after sequential ETs, but is associated with adverse side effects. We assessed physicians' preferences and self‐reported prescribing patterns for ET and CT in the treatment of HR+/HER2− mBC at community practices in the United States. Community‐based oncologists/hematologists from a nationwide online panel who treated postmenopausal women with HR+/HER2− mBC were invited to complete a survey, blinded to the identity of study sponsor. Treatment preferences were collected by treatment class of ET‐based regimens versus CT and by agent for postmenopausal HR+/HER2− mBC patients after prior nonsteroidal aromatase inhibitor use in the adjuvant or mBC setting. Among 213 physicians who completed the survey, 78% were male, 71% were based in small/intermediate practices (2–9 oncologists/subspecialists), 55% had >10 years of experience, and 58% referred to the National Comprehensive Cancer Network Guidelines when treating mBC. Among first‐line ETs, anastrozole was the most frequently used treatment (35%), followed by everolimus‐based (EVE, 34%) and fulvestrant‐based (FUL, 15%) therapy. After first‐line ET, the most preferred second‐ and third‐line treatments were ET monotherapy (48% and 39%), ET combination therapy (31% and 19%), and CT monotherapy (13% and 30%). Comparing EVE versus FUL, physicians preferred EVE in all lines but first line. Efficacy was the most important consideration for treatment choice. Physicians prescribed CT in early lines mainly because of visceral symptoms. This survey of treatment patterns for HR+/HER2− mBC in community practice suggested that after first‐line ET, ET mono‐ or combination therapy was commonly used for the second‐ and third‐line treatments and CT monotherapy for third‐ or later line treatments. CTs were used in early lines for patients with visceral symptoms.
The effect of aloe emodin–encapsulated nanoliposome‐mediated r‐caspase‐3 gene transfection and photodynamic therapy on human gastric cancer cells
Authors: Li Kai‐Ting , Duan Qin‐Qin , Chen Qing , He Juan‐Wen , Tian Si , Lin Hai‐Dan , Gao Qing , Bai Ding‐Qun 
Published: December 2015

AbstractGastric carcinoma (GC) has high incidence and mortality rates in China. Surgery and chemotherapy are the main treatments. Photodynamic therapy (PDT) has become a new treatment modality, appearing in recent experimental studies and clinical trials in various tumors. This study explores the combined effect of gene transfection with PDT on GC cells using aloe emodin (AE)–encapsulated nanoliposomes, which acted as gene carrier as well as one photosensitizer (PS). AE‐encapsulated nanoliposomes (nano‐AE) were prepared by reverse evaporation method. Electron microscopy and nano‐ZS90 analyzer were used to detect its morphology, size, and wavelength. Western blot was used to detect the expression of the caspase‐3 after transfection. MTT assay and flow cytometry were employed to determine the cytotoxic and apoptotic rates, respectively. Hoechst 33342 staining was adopted to detect the morphological changes in death gastric cancer cells. Cellular reactive oxygen species (ROS) contents were measured by DCFH‐DA staining. Outcomes demonstrated that the nano‐AE has good properties as gene delivery carriers as well as a PS. The group in which the recombinant plasmid of r‐caspase‐3 was transfected had higher protein expression of the caspase‐3 than controls, meanwhile the proliferation rates of the transfected cells were inhibited by the nano‐AE‐mediated PDT in an energy‐dependent manner. In addition, in the transfected cells, the death rate increased to 77.3% as assessed 12 h after PDT (6.4 J/cm2). Hochest 33342 staining also revealed that the death rate increased significantly in the transfected group compared with other groups. Compared to control groups, the production of ROS in nano‐AE PDT group had quadrupled in SGC‐7901 cells as early as 1 h after PDT, while it is similar to the group of nano‐AE transfection and PDT. Nano‐AE‐mediated r‐caspase‐3 gene transfection coupled with PDT could inhibit the proliferation rate and increase the apoptotic rate remarkably in human gastric cancer cells.
Cancer‐associated retinopathy as the leading symptom in colon cancer
Authors: Weixler Benjamin , Oertli Daniel , Nebiker Christian Andreas 
Published: December 2015

Key clinical messageCancer‐associated retinopathy (CAR) is a rare paraneoplastic visual syndrome. Its early detection may lead to the diagnosis of the causative malignancy. As many different types of malignancies are known to be associated with CAR, it is important that clinicians are aware of the phenomenon of CAR.
Reasons for Filter Bag Failure and Method Development to Improve its Life Span
Authors: Patnaik Asis , Anandjiwala Rajesh D. 
Published: December 2015

AbstractReasons for filter bag failure at steel plants were analyzed and a suitable approach to overcome such problems is proposed. Clean and used filter bags were tested to evaluate tensile and bursting strengths and air permeability properties. In order to simulate the behavior of the filter bags under acidic conditions normally encountered in actual working environment, an acid dew point test was conducted on the clean bags. The structural changes in all bags were determined by scanning electron microscopy. A significant reduction in tensile and bursting strengths was observed after acidic treatment. In order to improve the durability of the bags, they were coated with a mixture of acrylic binder and nanoclay. Commercial filter bags as well as the developed samples showed improved resistance without any failure behavior.
A Three‐Electrode, Battery‐Type Swagelok Cell for the Evaluation of Secondary Alkaline Batteries: The Case of the Ni–Zn Battery
Authors: Garcia Grecia , Schuhmann Wolfgang , Ventosa Edgar 
Published: December 2015

AbstractThree‐electrode cells are essential in understanding battery materials under operando conditions. A three‐electrode, battery‐type Swagelok cell for electrochemical studies of secondary alkaline batteries, in particular Ni–Zn batteries, is presented. The relevance of the three‐electrode battery‐type cell (i.e. sealed and non‐flooded) configuration is demonstrated as analytical tool with three observations: 1) The Ni electrode is shown to limit the system in the first cycles, while the Zn electrode becomes limiting in subsequent cycles. 2) Non‐woven separators (NWSs) clearly improve the performance of the battery. Besides the known fact of hindering the dendritic growth of Zn, NWSs inhibit the evolution of oxygen and hydrogen at the positive and negative electrodes. 3) The kinetics of the Ni electrode is much slower than that of the Zn electrode, as derived from the charge‐transfer resistance of the Ni electrode, which is substantially larger than that of the Zn electrode.
ChemInform Abstract: Charge Modulation in Graphitic Carbon Nitride as a Switchable Approach to High‐Capacity Hydrogen Storage.
Authors: Tan Xin , Kou Liangzhi , Tahini Hassan A. , Smith Sean C. 
Published: December 2015

AbstractElectrical charging of graphitic g‐C4N3 and g‐C3N4 nanosheets is proposed as a strategy for high‐capacity and electrocatalytically switchable H2 storage.
ChemInform Abstract: Synthesis of Novel Ammonium Vanadium Bronze (NH4)0.6V2O5 and Its Application in Li‐Ion Battery.
Authors: Ma Yining , Ji Shidong , Zhou Huaijuan , Zhang Shuming , Li Rong , Zhu Jingting , Li Wenjing , Guo Hehe , Jin Ping 
Published: December 2015

AbstractThe new title compound is hydrothermally synthesized from NH4VO3 in aqueous formic acid solution (autoclave, 250 °C, 8 h).
ChemInform Abstract: Visible Light Mediated Efficient Oxidative Benzylic sp3 C—H to Ketone Derivatives Obtained under Mild Conditions Using O2.
Authors: Yi Hong , Bian Changliang , Hu Xia , Niu Linbin , Lei Aiwen 
Published: December 2015

AbstractThe photooxidation of diarylmethanes (I) in the presence of 9‐mesityl‐10‐methylacridinium perchlorate as a photocatalyst yields benzophenones (II).
ChemInform Abstract: Convenient Stereoselective Synthesis of β‐Perfluoroalkyl α,β‐Unsaturated Esters via Horner—Wadsworth—Emmons Reactions.
Authors: Yamazaki Takashi , Mano Noriko , Hikage Reo , Kaneko Tsutomu , Kawasaki‐Takasuka Tomoko , Yamada Shigeyuki 
Published: December 2015

AbstractVarious title esters are obtained with high (E)‐stereoselectivity by condensation reactions of in situ produced halogenated ketones with Horner—Wadsworth—Emmons reagents.
ChemInform Abstract: Baeyer—Villiger Oxidation under Payne Epoxidation Conditions.
Authors: Bradley Tyne D. , Dragan Andrei , Tomkinson Nicholas C. O. 
Published: December 2015

AbstractThe novel method for the Baeyer—Villiger oxidation of ketones involves a transition metal‐free activation of H2O2 under Payne epoxidation conditions.
ChemInform Abstract: Synthesis of Substituted Tropones by Sequential Rh‐Catalyzed [5 + 2] Cycloaddition and Elimination.
Authors: Song Wangze , Xi Bao‐min , Yang Ka , Tang Weiping 
Published: December 2015

AbstractStarting from acyloxy‐1,4‐enynes and various 2‐substituted or 2,2‐disubstituted propargyl alcohols a regioselective access to acetyl protected tropone derivatives is developed.
ChemInform Abstract: Application of 1,4‐Bis(3‐methylimidazolium‐1‐yl)butane Ditribromide [bMImB]·(Br3)2 Ionic Liquid Reagent for Selective Oxidation of Sulfides to Sulfoxides.
Authors: Manesh Abbas Amini , Eshbala Fereshteh Hosseini , Hemmati Saba , Veisi Hojat 
Published: December 2015

AbstractNo over‐oxidation is observed, allylic and alcoholic functions remain intact.
ChemInform Abstract: Dimeric TADDOL Phosphoramidites in Asymmetric Catalysis: Domino Deracemization and Cyclopropanation of Sulfonium Ylides.
Authors: Klimczyk Sebastian , Misale Antonio , Huang Xueliang , Maulide Nuno 
Published: December 2015

AbstractThe diastereo‐ and enantioselective intramolecular cyclopropanation of allylic esters is achieved in the presence of the novel bimetallic gold catalyst (AUP).
ChemInform Abstract: The p‐Toluenesulfonic Acid‐Catalyzed Transformation of Polyfluorinated 2‐Alkynylanilines to 2‐Aminoarylketones and Indoles.
Authors: Politanskaya Larisa , Shteingarts Vitalij , Tretyakov Evgeny , Potapov Alexander 
Published: December 2015

AbstractThe reaction pathways significantly depend on the substituents on the alkynylaniline to provide the corresponding ketones or indoles.