bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Formulation and evaluation of sustained release tablet of divelproex sodium
Authors: Kusum , , Gupta Avinash Kumar , Gupta Manish Kumar , Sharma Vijay 
Published: September 2024

In the present work, formulation and evaluation of Sustained tablet of Divalproex sodium was carried out. In the project, different formulations of sustained release layer have been prepared. From above formulations best formulation of each sustained release was selected according to the dissolution profile. Divalproex sodium is soluble in 0.1 N NaOH, phosphate buffer pH 6.8, chloroform, methanol, ethanol (95%), and sparingly soluble in water. The absorbance maximum of the Divalproex sodium was found to be at 210 nm when scanned in between 200-400 nm using methanol as well as phosphate buffer pH 6.8 solutions. All the characteristic peaks of Divalproex sodium were present in the spectrum of drug and excipient mixture, indicating compatibility between drug and excipients. In the present work SR tablets of Divalproex sodium were prepared by wet granulation method, using polymer like HPMC K4M for sustained release. Best formulations of was selected for Divalproex sodium were subjected to hardness, weight variation, friability, drug content uniformity, in vitro drug release and drug polymer interaction.
Keywords: Divalproex sodium, Sustained Release, HPMC and Epilepsy.
A Review on Formulation and Evaluation of Sustained Release Tablet of Devilproex Sodium
Authors: Kusum , , Gupta Avinash Kumar , Gupta Manish Kumar , Sharma Vijay 
Published: September 2024

An appropriately designed drug delivery system can be a major step towards solving these two problems. This technique for the drug administration is termed as ‘sustained release’ or ‘controlled release. Drugs with dosage not exceeding 125mg – 325mg are more suited as extended release products in order to limit the size of the delivery system. In the case of soluble matrix the matrix swells or dissolves. These matrices then undergo surface erosion with little or no bulk erosion. Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. One of its most important characteristics is the high gelation velocity and viscosity, which has a significant effect on the release kinetics of the incorporated drug. It was proven that HPMC at high concentration promoted the drug release approaching to a zero-order release kinetic because of its gelation properties
Keywords: HPMC, Divalproex sodium, sustained release and zero-order release kinetic
Evaluation of Antimicrobial Profile of Some Novel 1, 3, 4-Oxadiazole Derivatives Followed by Molecular Docking Against 3G7E Bacterial DNA Gyrase
Authors: Bhaumik Asish , Chinna Eswaraiah M. , Chakraborty Raja 
Published: September 2024

The main aim and objective of the present research work was the design, synthesis, spectral characterization and evaluation of in vitro antimicrobial profile of some novel oxadiazole derivatives followed by molecular docking studies against bacterial DNA gyrase. The molecular structures of the synthesized compounds were assigned by IR, NMR and Mass spectral analysis. Molecular docking studies were carried out by AUTO DOCK programme. The in vitro antibacterial and antifungal activities were done by paper disk diffusion and agar streak dilution technique. In silico molecular docking studies the binding energy of synthesized compounds (AB1-AB8) were found to be -7.66, -7.67, -7.12, -7.12, -6.59, -6.46, -7.35, -5.09 which indicated that the compound had the high binding affinity towards the bacterial DNA gyrase with PDB id 3G7E and inhibit the function topoisomerase in comparison with standard drug ciprofloxacin (-7.44). The preliminary antimicrobial screening displayed that most of the synthesized compounds were executed moderate to good antimicrobial activity against following bacteria: S. aureus (ATCC 9144), B. subtilis (ATCC 6633), S. epidermidis (ATCC 12228), P. Aeruginosa (ATCC27853), E.coli (ATCC25922), V. cholerrae (ATCC14035) and fungi: A. Niger (ATCC 9029), A.flavus (ATCC204304), C. albicans (ATCC10231) and B. dermatitis (ATCC 26199) etc. All the synthesized compounds exhibited moderate to good antibacterial and antifungal activity with an MIC range of 12-37µg/ml. Among these eight synthesized oxadiazole derivatives, compound AB1; AB2 and AB7 were found to be very good antibacterial as well as antifungal potentiality with an MIC range of 13-12 µg/ml; 7-10 µg/ml and 15-18 µg/ml.
Keywords: Molecular docking; NMR; disk diffusion; antibacterial; antifungal and MIC etc.
A Review on Eight System Inspection Model
Authors: Jagatp Sneha R. , Bhusnure Omprakash G. 
Published: September 2024

The FDA's Drug Manufacturing Inspection Compliance Program, which constitutes instructions to FDA personnel for conducting inspections, is a systems-based approach for inspections and is very consistent with the robust quality systems model presented in this guidance. The diagram below shows the relationship among the six systems: the quality system and the five manufacturing systems. The quality system provides the foundation for the manufacturing systems that are linked and function within it. The quality systems model described in this guidance does not treat the five manufacturing systems as discrete entities, but instead integrates them into appropriate sections of the model. Those familiar with the six-system inspection approach will see organizational differences in this guidance; however, the inter-relationship. Generally, the term quality unit is used in this guidance. However, quality control unit is used when directly quoting parts. United States Food and Drug Administration (USFDA) propose Six System Inspection Model for the audit of pharmaceutical organization for minimization of regulatory submission. Author studied this system, then added and modified this to Eight System Inspection Model to make this more useful and user friendly for the pharmaceutical organization which wants to go for USFDA or other international audits. While doing this author added two additional systems (Management/Regulatory) and four additional points (Validation, HVAC System Validation, Water and Steam System Validation and Vendor Certification).
FORMULATION AND EVALUATION OF NASAL INSITU GEL OF SUMATRIPTAN SUCCINATE FOR THE TREATMENT OF MIGRAINE
Authors: Aabid P K , Ashwani M. 
Published: September 2024

In situ gelling system are better and formulation of time since they have multiple advantages over conventional drug delivery system includes better bioavailability ,retention on the desired site and patient compliance .Nasal drug delivery is a better option to deliver drug across Blood brain barrier and in this research work an attempt was made to prepare insitu temperature triggered nasal gel of Sumatriptan Succinate for the treatment of Migraine .For the preparation of best insitu gel Poloxamer 188 in different concentration was used to formulate insitu gel along with HPMC K4M .The optimized formulation was chosen after evaluating the prepared gel for pH, Viscosity, Gel strength and mucoadhesive strength then final optimized formulation was subjected for texture analysis ,in vitro drug release and Differential Scanning Calorimetery and drug release data was also evaluated for Release kinetic of formulation .Formulation batch F5 was selected as best formulation batch because it exhibited best result among all the prepared formulation and proved as promising temperature triggered formulation of insitu gel.
DEMONSTRATION OF LYMPHATIC UPTAKE OF (6)-GINGEROL SOLID LIPID NANOPARTICLES
Authors: Bhalekar Mangesh R , Madgulkar Ashwini , Jagtap Tejaswini Vikram 
Published: September 2024

(6)-Gingerol, a disease modifying anti-rheumatoid drug (DMARD) agent in the treatment of Rheumatoid Arthritis is a potent inhibitor of COX-1, COX-2 activity, inhibits PGE2 production. It also inhibits the production of TNF-α by blocking the cell associated conversion of TNF precursor to mature proteins thus, halting the proliferation of synovitis. (6)-Gingerol undergo extensive phase I metabolism & underlies low systemic exposure. The aim of the present study was to overcome these limitations and formulate and evaluate Ginger extract Solid Lipid Nanoparticles to improve bioavailability by enabling lymphatic uptake. (6)-Gingerol Solid Lipid Nanoparticles were prepared by melt emulsification-homogenization method and the particle size, Zeta potential PDI and % entrapment efficiency was optimized using Box Behnken design. The optimized SLN were found to be 237nm in size, bearing -25.3mv zeta potential, 0.350 PDI and entrapment efficiency of 91.33%. Ex vivo endocytic uptake studies (everted intestine method) revealed involvement of endocytic pathways in the uptake of Solid Lipid Nanoparticles from intestine. Thus underlining the utility of SLN for enhancement of uptake of (6)-Gingerol.
АНАЛІТИЧНИЙ ОГЛЯД ЗАРУБІЖНОГО ТА ВІТЧИЗНЯНОГО ДОСВІДУ ЩОДО НАВЧАННЯ УЧНІВ ОСНОВ СУЧАСНОГО ВИРОБНИЦТВА НА УРОКАХ ТЕХНОЛОГІЙ
Authors: Корець Олександр , Мельников Олексій 
Published: September 2024

У статті поданий аналітичний огляд проведених досліджень вітчизняних і зарубіжних учених та практиків щодо навчання учнів основ сучасного виробництва на уроках технологій. Проведений контент-аналіз дав змогу охарактеризувати особливості української освітньої системи, де під час практичних занять часто обмежується використанням застарілого обладнанням та верстатного парку, натомість у школах зарубіжних країн, таких як Німеччина та Японія реалізується тісна взаємодія освіти з сучасним виробництвом, в якому здійснюється системне впровадження новітніх технологій. Вноситься пропозиція щодо запровадження кращого досвіду до вітчизняної практики, зокрема, залучення до співпраці з промисловими підприємствами і оновлення навчальних програм із залученням курсів з робототехніки, програмування та цифрової грамотності, спрямованих на пропедевтичну підготовку кваліфікованих кадрів для сучасного ринку праці.
ОПЕРАТОРСЬКЕ МИСТЕЦТВО ЯК ОБʼЄКТИВОВАНА КУЛЬТУРНА РЕАЛЬНІСТЬ В ПРОСТОРОВИХ І ЧАСОВИХ СТРУКТУРАХ ВІДЕООПИСУ
Authors: Борденюк Сергій , Гончаренко Микола , Небера Павло 
Published: September 2024

У статті проаналізовано парадигму операторської майстерності у частині візуальної розповіді в просторових і часових координатах. Простежено дисиміляцію та уподібнення між структурами відеоопису, окреслено основні структурні елементи в операторській майстерності та зазначено доцільність їх використання в сучасному аудіовізуальному виробництві.
Використано такі методи дослідження, а саме: теоретичний – аналіз кінематографічних творів у частині операторської майстерності, визначення структурних компонентів, які формують візуальну оповідь; порівняльний – проведення паралелей між структурами відеоопису; практичний – моделювання конкретних прикладів уречевлення культурної реальності у просторових і часових координатах засобами операторської майстерності.
Compulsão alimentar periódica em acadêmicos de medicina
Authors: Korin Stella Hissami , Souza José Carlos Rosa Pires de , Leite Lucas Rasi Cunha , Cabral Flávio Junior Ferraz 
Published: September 2024

Objetivo: Avaliar a prevalência de Transtorno de Compulsão Alimentar Periódico (TCAP) em acadêmicos de medicina, caracterizando a associação entre TCAP e perfis sociodemográficos. Métodos: Trata-se de um estudo transversal quantitativo com acadêmicos da 1 a à 4 a série do curso de medicina de uma universidade localizada em Campo Grande (MS). Realizou-se a aplicação de um questionário sociodemográfico e da Escala de Compulsão Alimentar (ECAP). O estudo foi aprovado por Comitê de Ética em Pesquisa. Resultados: Das 120 respostas, obteve-se a prevalência de 17,5%, sendo 13,3% compatível com TCAP moderada e 4,2% TCAP grave. Além disso, a mediana dos pontos do ECAP foi 7 (P25: 3, P75: 15), variando entre zero e 41 pontos, e a média foi de 9,858 (DP ± 8,08). Os participantes apresentaram perfil sociodemográfico homogêneo, havendo somente associação entre TCAP e os meio de transporte utilizado para ir à universidade (p = 0,026) e para ir aos campos de estágio (p = 0,039). Não houve associação com sexo biológico, idade, etnia, renda familiar, vínculo empregatício, auxílio financeiro governamental, e tipo de moradia. Conclusão: Há maior prevalência de TCAP em acadêmicos de medicina em relação à população geral, no entanto, não há associação significativa com fatores sociodemográficos.
Treinamento vocal para professores universitários
Authors: Navarro Leoni da Silva , Silva Sheila Aparecida da , Andrade Sylvia Gabriela Duarte Licíndio , Sampaio Antônio Carlos Freire 
Published: September 2024

Objetivo: Mapear existência de estratégias de treinamento vocal para professores universitários e investigar distúrbios vocais presentes na voz do professor do Ensino Superior e se disponível apresentar as descrições desses distúrbios. Métodos: Trata-se de uma revisão de escopo, que seguiu a proposta metodológica do Joanna Briggs Institute. As buscas ocorreram nas bases de dados e bibliotecas digitais via portal de periódicos CAPES e realizadas em nove bases de dados, entre maio e junho de 2023. A seleção foi realizada por dois autores de forma independente e um terceiro autor resolveu as divergências. Resultados: foram identificados 748 estudos. Após aplicação dos critérios de elegibilidade, foram avaliados se respondiam ou não à pergunta de pesquisa; foram mapeados 10 estudos primários, sendo publicações nacionais e internacionais. As estratégias de treinamento vocal relatadas foram terapia breve e intensiva com técnica finger kazzo, massagem perilaríngea manual, treinamento vocal tradicional, programas de treinamento preventivo em voz, uso do tubo de ressonância e assessoria Fonoaudiológica. Os distúrbios vocais citados foram: nódulos nas pregas vocais e disfonia comportamental com sintoma de fadiga vocal e rouquidão por tensão muscular. Considerações finais: Os treinamentos vocais identificados contribuíram com o bem estar e qualidade vocal dos docentes.
Cuidados paliativos no tratamento de pacientes com doença terminal
Authors: Andrade Ana Marcia Soares , Borges Filho Angelo Marcos , Paranhos Maria Clara Mahmoud Qasgas , Souza Diego Gonçalves Oliveira 
Published: September 2024

Objetivo: Investigar na literatura a eficácia dos cuidados paliativos em pacientes com doença terminal. Métodos: Revisão Integrativa da Literatura. Foram considerados como estratégias de busca, as seguintes palavras-chave registradas nos Descritores em Ciências da Saúde (DeCs): “Cuidados paliativos”, “câncer”, “eficácia”, “paliatividade”, “qualidade de vida”, “apoio psicossocial”, “comunicação”, “tratamento”, “doença terminal”. Resultados: Foram selecionados oito estudos. Quanto aos aspectos metodológicos, 50% dos estudos selecionados correspondem a estudos de coorte retrospectivos, 12,5% estudos de coorte prospectivos, 12,5% a ensaios clínicos randomizados, 12,5% a estudos longitudinais e 12,5% a estudos qualitativos. A amostra variou de 12 pacientes a 445 pacientes. Toda a amostra foi composta por pacientes em estado terminal de vida. A implementação da paliatividade pode promover modificações positivas na comunicação e no cuidado, resultando na identificação de múltiplas necessidades de controle de sintomas, comunicação e recomendações importantes associadas ao tratamento dos pacientes. Considerações finais: Os cuidados paliativos podem ser considerados eficazes para oferecer melhoria da qualidade de vida de pacientes oncológicos, mesmo quando realizados tardiamente. Os pacientes devem ser abordados de forma individualizada, considerando os aspectos culturais, sociais e da própria doença, de modo a oferecer redução dos sintomas, conforto e, melhor comunicação diante das transições dos cuidados.
PERFORMANCE ANALYSIS OF HIGH SPEED AXIAL FLUX PERMANENT MAGNET GENERATORS
Authors: Исмагилов Ф.Р. , Вавилов В.Е. , Саяхов И.Ф. , Ематин Е.А. 
Published: September 2024

Проведен расчет основных геометрических размеров и электромагнитных параметров дискового высокооборотного генератора с постоянными магнитами. Методами компьютерного моделирования проведен анализ трех основных топологий дисковых генераторов для оценки производительности и сопоставления массоэнергетических характеристик. Получены зависимости выходного напряжения от тока нагрузки, определены удельные массы, проведена оценка потерь на вихревые токи в постоянных магнитах, также исследовано влияние ширины тангенциально намагниченных магнитов в массиве Халбаха на максимальное значение выходного напряжения генератора. Из результатов анализа получено, что конструкция дискового высокооборотного генератора с двухсторонними внешними роторами с массивами Халбаха и безжелезным статором обладает более низкой удельной массой, малыми потерями на вихревые токи и в то же время имеет жесткую внешнюю характеристику по сравнению с конструкциями дисковых генераторов, содержащих магнитопроводы. Изменение ширины тангенциально намагниченных магнитов в массиве Халбаха позволяет повысить максимальное генерируемое напряжение, что позволяет проектировать генераторы такого типа более энергоэффективными.
The calculation of the main geometric dimensions and electromagnetic parameters of a highspeed generator of permanent magnets. Computer simulation methods have analyzed three main topologies of disk generators to evaluate performance and compare massenergy characteristics. The dependences of the output voltage on the load current were obtained, the specific weights were determined, the eddy current losses in permanent magnets were estimated, the influence of the width of the tangentially magnetized magnets in the Halbach array on the maximum value of the generator output voltage was also studied. From the results of the analysis, it was found that the design of a highspeed disk generator with doublesided external rotors with Halbach arrays and an ironfree stator has a lower specific weight, low eddy current losses and at the same time has a hard external characteristic compared to the designs of disk generators containing magnetic circuits. Changing the width of the tangentially magnetized magnets in the Halbach array allows you to increase the maximum generated voltage, which allows you to design generators of this type more energy efficient.
Evaluation of decorative of tree peonies for gardening of cities of the Republic of Bashkortostan
Authors: Реут А.А. 
Published: September 2024

Обсуждаются результаты интродукционного изучения древовидных пионов (Paeonia suffruticosa Andrews, P. delavayi Franch.) на базе ЮжноУральского ботанического садаинститута УФИЦ РАН. Описаны сведения по культуре видов. Приведены фенологические данные, стадии генеративного развития растений (цветение, плодоношение). Представлены морфометрические описания растений (диаметр и высота цветка, число лепестков, длина и ширина лепестка, длина и ширина семян и т.д.). Дана оценка декоративных признаков пионов, в результате которой наибольший балл (94) получил P. suffruticosa. На основе оценки успешности интродукции испытанных видов показана их перспективность для культивирования в условиях лесостепной зоны Башкирского Предуралья. Даны рекомендации по использованию древовидных пионов в зеленом строительстве Республики Башкортостан.
The article discusses the results of the introduction study of tree peonies (Paeonia suffruticosa Andrews, P. delavayi Franch.) on the basis of the SouthUral Botanical GardenInstitute of UFRS RAS. Information on species culture is described. Phenological data, stages of generative development of plants (flowering, fruiting) are presented. Presented morphometric description of the species (diameter and height of the flower, number of petals, length and width of petal, length and width of seeds, etc.). The estimation of decorative features of peonies is given, which revealed that the highest number of points (94) received P. suffruticosa. Based on the assessment of the success of species introduction, their prospects for cultivation in the foreststeppe zone of the Bashkir Urals are shown. Recommendations on the use of tree peonies in the green construction of the Republic of Bashkortostan are given.
Biomorphological features of a rare species - Salsola daghestanica (Turcz.) Turcz. in Dagestan
Authors: Магомедова Б.М. , Гасайниева З.А. 
Published: September 2024

Приводятся сведения по биоморфологии редкого вида, занесенного в Красную книгу Дагестана и являющегося эндемиком Восточного Кавказа Salsola daghestanica (Turcz.) Turcz. Особи S. daghestanica произрастают на склонах восточной и северозападной экспозиции хребта Надырбек в Казбековском районе Дагестана (окрестности с. Дубки) и отличаются по биоморфологическим параметрам. У особей, занимающих восточную экспозицию склона, средние показатели высоты, диаметра и ширины больше. Относительно ранее изученных нами ценопопуляций S. daghestanica данная имеет большие морфологические характеристики. Можно сделать вывод, что почвенноклиматические условия произрастания казбековской ценопопуляции способствуют лучшему проявлению биоморфологического потенциала растений Salsola daghestanica. Общая численность особей S. daghestanica составляет около 300, занимающих 1 га. Проективное покрытие травянистого яруса 30 , сомкнутость кустарникового яруса составляет 35 . Доминантом выступает Caragana grandifl ora DC., встречаемость которой составляет 25 . Первый ярус, вместе с S. daghestanica (Turcz.) Turcz., образуют Spiraea hypericifolia L., Сolutea orientalis Mill., Paliurus spinachristi Mill., Lonicera iberica M. Bieb., Atraphaxis replicata Lam., Rhamnus pallasii Fisch. et C.A. Mey., Tamarix ramasissima Ledeb., Cerasus incana (Pall.) Spach, Artemisia salsoloides Willd., Satureja subdentata Boiss, Reaumuria alternifolia (Pall.) Spach.
The article provides information on the biomorphological characteristics of the bushes of a rare species listed in the Red Book of Dagestan and which is an endemic of the Eastern Caucasus Salsola daghestanica (Turcz.) Turcz. Individuals of S. daghestanica grow on the slopes of the eastern and northwestern exposition of the Nadyrbek ridge in the Kazbek district of Dagestan (near the village of Dubki) and differ in biomorphological parameters. The individuals occupying the eastern exposure of the slope have a higher average height, diameter and width. Regarding the S. daghestanica cenopopulations previously studied by us , this one has great morphological characteristics of plants. It can be concluded that the soil and climatic conditions of growth of the Kazbek coenopopulation contribute to a better manifestation of the biomorphological potential of the Salsola daghestanica plants. The total number of individuals S. daghestanica is about 300, occupying 1 ha. The projective cover of the grassy layer is 30, the closeness of the shrub layer is 35. The dominant is Caragana grandifl ora DC., the incidence of which is 25. The first tier, together with S. daghestanica (Turcz.) Turcz., form Spiraea hypericifolia L., Сolutea orientalis Mill., Paliurus spinachristi Mill., Lonicera iberica M. Bieb., Atraphaxis replicata Lam., Rhamnus pallasii Fisch. et C.A. Mey., Tamarix ramasissima Ledeb., Cerasus incana (Pall.) Spach, Artemisia salsoloides Willd., Satureja subdentata Boiss, Reaumuria alternifolia (Pall.) Spach.