bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevance of the common‐sense model for people living with a genetic predisposition for breast and ovarian cancer
Authors: Fantini‐Hauwel Carole , Geerts‐Crabbé Laura , Antoine Pascal 
Published: September 2024

AbstractObjectivesBRCA1/2 pathogenic variants have been associated with an increased risk for breast, ovarian, pancreatic, prostate cancer as well as melanoma. The present research uses the Leventhal's common‐sense model of self‐regulation (CSM), a theoretical framework highlighting the role of mental representations on responses to a health‐threat. We aim at understanding the personal meaning and representation of living with an hereditary breast and ovarian cancer predisposition.MethodSemi‐structured interviews of 15 BRCA carriers were analysed using the interpretative phenomenological analysis.ResultsMental representations develops in childhood and are influenced by childhood emotional responses to the familial experience of the BRCA predisposition. Pre‐existing beliefs about BRCA, even erroneous, are deeply anchored and not called into question by medical informations given during the genetic counselling. This is particularly true when medical information is perceived as too complex, inconsistent or in contradiction with familial experience. These beliefs about the consequences of being carriers of the BRCA gene influence emotional and behavioural experiences leading to experience fear, anxiety, lack of hope for future or self‐identity change. For participants with a traumatic familial experience of cancer, the lack of treatment for this genetic disease generates a perpetual overestimation of cancers’ risk and the feeling of an unending danger associated with early death despite breast and ovarian prophylactic surgery. When strong negative representations of the BRCA predisposition are experienced, dysfunctional health behaviours, such as drugs consumption or overuse of medical consultations, could appear consecutively to emotional disorders.
Review of susceptibility genes in developmental dysplasia of the hip: A comprehensive examination of candidate genes and pathways
Authors: Wang Wenla , Zhuang Wei , Zeng Wenxiang , Feng Yuqi , Zhang Zhaowei 
Published: September 2024

AbstractDevelopmental dysplasia of the hip (DDH) is one of the most prevalent skeletal deformities, primarily due to the incompatibility between the acetabulum and femoral head. It includes complete dislocation, partial dislocation, instability with femoral head subluxation, and a range of imaging abnormalities that reflect inadequate acetabular formation. Known risk factors for DDH include positive family history, sex, premature birth, non‐cephalic delivery, oligohydramnios, gestational diabetes mellitus, maternal hypertension, associated anomalies, swaddling clothes, intrauterine space restriction, and post‐term pregnancy. Various research designs have been employed in DDH studies to identify relevant genes, including candidate gene association studies (CGAS), genome‐wide association studies (GWAS), restriction fragment length polymorphism (RFLP), and whole exome sequencing (WES). To date, multiple DDH‐associated genes have been identified in various populations. Despite extensive research into the epidemiology, risk factors, and genes associated with DDH, its pathogenesis remains unclear. This study provides a comprehensive summary of DDH research designs and evidence for relevant gene mutations through a PubMed search.
Phase concept: Novel dynamic endoscopic assessment of intramural antireflux mechanisms (with video)
Authors: Inoue Haruhiro , Tanabe Mayo , Shimamura Yuto , Yamamoto Kazuki , Nishikawa Yohei , Ushikubo Kei , Iwasaki Miyuki , Tanaka Hidenori , Tanaka Ippei , Owada Kaori , Abiko Satoshi , Onimaru Manabu , Seewald Stefan 
Published: September 2024

ObjectivesThe gastroesophageal junction (GEJ) consists of various anatomical components that together form a barrier to prevent reflux of gastric content. This study introduces a novel phase concept to dynamically evaluate the antireflux barrier (ARB) during endoscopy and analyzes its functionality.MethodsWe reviewed previously the recorded endoscopic videos of subjects who underwent the endoscopic pressure study integrated system (EPSIS) from February to April 2024 for indications other than gastroesophageal reflux disease symptoms. This device was used as an auxiliary tool to measure intragastric pressure (IGP) during endoscopy with a retroflex view. The ARB dynamic was divided into three phases: Phase I (gastric phase), Phase II (lower esophageal sphincter phase), and Phase III (esophageal clearance phase). We evaluated the morphological changes in the ARB during insufflation using EPSIS.ResultsThe median age of the 30 subjects was 58 years (interquartile range [IQR] 46.5–68.8), including 20 men and 10 women. Endoscopic findings and IGPs were recorded during the three phases. In Phase I, at low IGP (median 6.75 mmHg), the gastroesophageal flap valve and longitudinal folds were observed in 80% of cases. In Phase II, at moderate IGP (median 11.8 mmHg), the scope holding sign was observed in 86.7%. In Phase III, at high IGP (median 19 mmHg) inducing belching, peristalsis was observed in 80% of cases with median recovery time of 5 s.ConclusionThe phase concept provides a valuable framework for understanding the antireflux mechanism. Further research is needed to validate these findings in GEJ disorders and explore correlations with other modalities.
Progression of hippocampal subfield atrophy and asymmetry in Alzheimer's disease
Authors: Xu Jingjing , Tan Sijia , Wen Jiaqi , Zhang Minming ,   For the Alzheimer's Disease Neuroimaging Initiative, Xu Xiaojun 
Published: September 2024

AbstractAlzheimer's disease (AD) affects the hippocampus during its progression, but the specific observable changes of hippocampal subfields during disease progression remain poorly understood. In this study, we employed an event‐based model (EBM) to determine the sequence of occurrence of hippocampal subfield atrophy in mild cognitive impairment (MCI) and AD cohorts. Subjects (207) were included: 86 MCI, 53 AD, and 68 healthy controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Participants underwent structural magnetic resonance imaging (MRI) scans to analyse the hippocampal subfields. We assigned each patient to a specific EBM stage, based on the number of their abnormal subfields. A combination of 2‐year follow‐up MRI scans were applied to demonstrate the longitudinal consistency and utility of the model's staging system. The model estimated that the earliest atrophy occurs in the hippocampal fissure, then spreading to other subregions in both MCI and AD. We identified a marked divergence between the sequences of left and right hippocampal subfields atrophy, so inter‐hemispheric asymmetry pattern was further analysed. The sequence of asymmetry index (AI) increases beginning in the molecular and granule cell layers of the dentate gyrus (GC‐ML‐DG), cornus ammonis (CA) 4, and the molecular layer (ML). Longitudinal analysis confirms the efficacy of the model. In addition, the model stages were significantly correlated with patients' memory scores (p < .05). Collectively, we used a data‐driven method to provide new insight into AD hippocampal progression. The present model could aid in understanding of the disease stages, as well as tracking memory decline.
Existence of equilibria in persuasion games with costly information acquisition
Authors: Montes Alfonso 
Published: September 2024

AbstractThis paper studies public information disclosure in games with rationally inattentive players. We establish how the existence of an optimal sender's strategy depends on the nature of the receivers' information cost. When the receivers' cost is strongly Uniformly Posterior Separable (UPS), selecting the sender's most preferred equilibrium (SPE) for every interim belief guarantees a solution to the information design problem. We provide an example with a (non‐strongly) UPS cost function in which an optimal sender's strategy does not exist despite the selection of the SPE.
The impact of calcium sequestration on the material and structural properties of acid milk gels and corresponding cream cheeses
Authors: Kim Jiuk , Watkinson Philip , Matia‐Merino Lara , Golding Matt 
Published: September 2024

SummaryWe report on the role of ethylenediaminetetraacetic acid (EDTA) in addition to the structural and material properties of acid milk gels formed via addition of glucono‐delta‐lactone (GDL) and these properties of corresponding analogue cream cheeses prepared from these gels. Increasing addition of EDTA to cheese milks prior to acidulation reduced the concentration of insoluble calcium in the milks. Acid gelation of milks, as measured by small deformation rheology, showed a decreased rate of gelation and lower relative elastic modulus of gels with increasing EDTA concentration. The sequestration of colloidal calcium phosphate from the casein micelle by the addition of EDTA led to the lower gelation rate and elastic modulus. The lower extent of ionic binding is considered the causative mechanism for formation of weaker gel structures. Cream cheeses prepared using acid gels with GDL acidulant were compositionally unaffected by EDTA concentration. However, variations in G′ observed in the acid gels containing increasing levels of EDTA correlated with large deformation material property changes in cream cheese analogues. In addition, the increasing inclusion of EDTA in cheese milks translated to reduced water‐holding capacity of the cream cheeses prepared from those milks. These results provide insights on the specific role of milk calcium on the structure, material and physical properties of acid milk gels and corresponding cream cheese analogues.
The role of dietary fibre in intestinal heat shock protein regulation
Authors: Rini Dina Mustika , Sitolo Gertrude Cynthia , Adesina Precious Adedayo , Suzuki Takuya 
Published: September 2024

SummaryThe gastrointestinal tract serves as a pivotal physical barrier that prevents the translocation of exogenous substances from the intestinal lumen into the systemic circulation. Dysfunction of intestinal barrier function has been implicated in the pathogenesis of several diseases, such as metabolic disorders. Heat shock proteins (HSPs) play a critical role in maintaining the resilience and viability of epithelial cells when exposed to stressors. Evidence suggests that dietary fibre (DF), a known inducer of HSP production, may be a promising candidate for strengthening the intestinal barrier. Understanding the regulation of intestinal HSPs and the protective effect of DF is critical to defending against environmental threats and preserving human health. To date, six DFs—pectin, chicory, psyllium, guar gum, partially hydrolysed guar gum, and xylooligosaccharide—have been reported to have promotive effects on intestinal HSP induction. DF promotes intestinal HSP induction through gut microbiota‐dependent and independent mechanisms. DF is fermented by gut microbiota to produce short‐chain fatty acids, specifically butyrate and propionate, to promote HSP production. Meanwhile, DF also promotes intestinal HSP induction through direct interaction with intestinal epithelial cells, independent of gut microbiota activity, although the precise mechanism is still unclear. Regulation of intestinal HSP occurs by transcriptional modulation through activation of heat shock transcription factors, primarily heat shock factor 1, or at the post‐transcriptional level by modulation of the translation process. This review highlights recent advances in understanding the role of DF in improving intestinal barrier function, with particular emphasis on the regulatory mechanisms of intestinal HSPs.
The role of diversification in stabilizing bank credit over the business cycle
Authors: Šeho Mirzet , Haque Md. Mahmudul , Chowdhury Mohammad Ashraful Ferdous 
Published: September 2024

AbstractWe investigate whether diversification stabilizes bank lending cyclicality on a sample of 25 conventional and 18 Islamic banks from Malaysia spanning 2008 to 2021. Our findings reveal that both bank types are nonlinearly procyclical during economic expansions, with Islamic banks also exhibiting countercyclical behavior during economic contractions. Diversification is positively associated with credit growth in conventional banks and Islamic bank subsidiaries, and it amplifies procyclicality across all Islamic bank types. Conversely, loan concentration stabilizes credit in Islamic banks. These results are robust to an alternative credit measure. Further analyses indicate that public and foreign banks are procyclical during booms and countercyclical during busts. At the same time, diversification heightens procyclicality in private, local, and foreign banks, whereas concentration mitigates it in public and local banks.
Unearthing waste resources: Nano‐adsorbents from complex packaging waste for fluoride detoxification of water
Authors: Ghinangju Bikesh , Hossain Rumana , Sahajwalla Veena 
Published: September 2024

AbstractThis study investigates the synthesis and characterization of Al2O3 nanoparticles derived from multilayered packaging (MLP) waste, specifically postconsumer coffee capsules, and evaluates their efficacy in fluoride adsorption from aqueous solutions. The nanoparticles were synthesized using a facile thermal degradation technique followed by leaching and precipitation processes. Characterization techniques, including inductively coupled plasma‐mass spectroscopy, XRF, Fourier transform infrared spectroscopy, X‐ray diffraction, and transmission electron microscope, confirmed the formation of γ‐Al2O3 nanoparticles with a cubic crystal structure. The adsorption process was found to be endothermic and spontaneous, with a maximum adsorption capacity of 9.60 mg/g. Kinetic studies revealed that the pseudo‐second order model best described the adsorption process, indicating a complex multistep mechanism involving both physisorption in the initial rapid adsorption and chemisorption in the latter slower phase. The Freundlich–Langmuir isotherm provided the best fit for equilibrium data suggesting a complex adsorption mechanism involving both homogeneous and heterogeneous surface interactions. The presence of competing anions, particularly carbonate and phosphate, significantly affected the adsorption efficiency. This research demonstrates the potential of upcycling MLP waste into valuable adsorbents for wastewater treatment applications, offering both environmental and economic benefits.
Oxidation mechanism and kinetics of TiB2 submicron powders in air
Authors: Li Xin , Tang Jian , Qiao Jia , Chen Bin , Shen Hongfang 
Published: September 2024

AbstractHigh‐activity TiB2 submicron powders were synthesized via microwave‐assisted carbothermal reduction, and their oxidation behavior at 550°C–1000°C for 0.5–1.5 h in air atmosphere was carried out by the isothermal oxidation test. The phase composition and microstructure evolution of the oxidation products were performed by X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). It was established that TiB2 submicron powders had been significantly oxidized at 550°C, and the oxidation products were TiO2 and B2O3. Hexagonal plate‐like TiB2 grains had been completely disappeared, and fragmented into uniform nano‐scale spherical TiO2 particles after being oxidized at 1000°C for 1 h, accompanied by the violent evaporation of B2O3 products at temperatures above 1000°C. In addition, the corresponding oxidation kinetics was investigated by using a non‐isothermal thermogravimetric (TG)–differential scanning calorimetry (DSC) technique. The results showed that the Mample power law (n = 1) was the most probable mechanism function, and the oxidation activation energy E of TiB2 submicron powders was 640.58 kJ/mol.
Do Firms Gain From Managerial Overconfidence? Managerial Bargaining Power and the Role of Severance Pay
Authors: Graziano Clara , Luporini Annalisa 
Published: September 2024

ABSTRACTWe analyze the effects of optimism and overconfidence when the manager has bargaining power and the compensation package includes severance pay. Optimism implies that the manager overestimates the probability of success, while overconfidence induces the manager to overestimate the increase in the probability of success due to her investment. If the manager can renegotiate the initial contract, the advantage of using severance pay to induce the manager to invest, commonly found in the literature, is reduced by the presence of the biases. Optimism increases severance pay and managerial entrenchement with a negative effect on expected profit. Overconfidence reduces incentive pay, as shown by the previous literature, but its effect on severance pay depends on the intensity of the bias. A moderate overconfidence reduces severance pay and increases expected profit. Conversely, extreme overconfidence increases severance pay and this may offset the beneficial effect on incentive pay. Thus, the attempt to exploit managerial overconfidence to reduce incentive pay may backfire if the manager is replaced. Our model suggests that the large severance payments documented by the empirical literature represent a form of efficient contracting when the optimistic and overconfident manager has bargaining power.
The “Kill Zone”: When a Platform Copies to Eliminate a Potential Threat
Authors: Motta Massimo , Shelegia Sandro 
Published: September 2024

ABSTRACTA monopoly platform may prevent a startup which sells a complementary product from developing a competing platform by copying it. Imitation reduces the potential rival's profits from the new platform and thus its incentives to invest. The anticipation of the incumbent's aggressive behavior may also create an “ex ante” effect, by inducing the rival not to challenge the incumbent with a new platform (i.e., not to enter the “kill zone”) and to develop another (noncompeting) product instead. This finding is robust to several extensions.
Association between pathological T1 colorectal cancer with lymphoid follicular replacement and risk of lymph node metastasis
Authors: Inaba Atsushi , Ikematsu Hiroaki , Kojima Motohiro , Sakamoto Naoya , Wakabayashi Masashi , Sunakawa Hironori , Nakajo Keiichiro , Murano Tatsuro , Kadota Tomohiro , Shinmura Kensuke , Yano Tomonori 
Published: September 2024

AbstractBackground and AimEndoscopic resection (ER) is widely performed to treat early colorectal cancer. However, additional surgery for pathological T1 colorectal cancer (pT1CRC) after ER is controversial because of the imprecise prediction of lymph node metastasis (LNM). Recently, several patients of pT1CRC with lymphoid follicular replacement (LFR) without LNM have been reported. This study aimed to investigate the clinicopathological features and risk of LNM in patients with pT1CRC with LFR.MethodsWe retrospectively analyzed patients who underwent ER or surgical resection and were diagnosed with pT1CRC between January 2010 and December 2020. We defined pT1CRC with LFR as the replacement of a part of the lymphoid follicular component within the submucosal area by adenocarcinoma, with no invasion into other submucosal areas.ResultsAmong the 600 eligible patients, the incidence rate of pT1CRC with LFR was 6.7% (40/600). Patients with pT1CRC with LFR represented 14.3% (37/258) of the endoscopically treated patients and 0.9% (3/342) of the surgically treated patients. For patients with pT1CRC with LFR, 80.0% (32/40) had flat and depressed lesions, and 35.0% (14/40) had submucosal invasion depth ≥1000 μm. Patients with pT1CRC with LFR had negative lymphovascular invasion, differentiated type, and budding grade 1. In the median follow‐up of 61 months, patients with pT1CRC with LFR had no LNM.ConclusionsThe presence of LFR in pT1CRC may be associated with a low risk of LNM. In patients with pT1CRC with LFR, follow‐up without additional surgery is possible even if the submucosal invasion depth is ≥1000 μm.
Toward inclusive and equitable LGBTIQ+ measurement: Assessing gender and sexual orientation measures and scale validity in national surveys across 21 countries
Authors: Li K. Colin , van Berlekom Elli , Atwood S. , Wang Yu‐Chi 
Published: September 2024

AbstractDespite growing global interest in lesbian, gay, bisexual, trans, intersex, and queer/questioning (LGBTIQ+) research, variations in measurement practices across countries have remained underexplored. In this work, we focused on two fundamental aspects of measurement vital to understanding the experiences of LGBTIQ+ people. Specifically, we documented current measures of sex, gender, and sexual orientation used in national mental well‐being‐related surveys and reviewed whether the mental well‐being scales in those surveys have been validated for LGBTIQ+ people. We employed a stratified sampling strategy and evaluated national surveys from a list of randomly selected countries representing 10% of global nations (N = 21). Fewer than half of the countries measured sexual orientation and fewer than one‐third measured gender beyond the binary in their national surveys. Among the countries that measured gender or sexual orientation, the response options and question phrasing were often not inclusive. In addition, most of the mental well‐being scales lacked validity evidence for LGBTIQ+ populations. Finally, we outline recommendations for the future of reimagining LGBTIQ+ research in terms of measurement, highlighting the importance of research engagement with the global LGBTIQ+ community.
Exome Sequencing of a Blastomycosis Case–Control Cohort From Manitoba and Northwestern Ontario, Canada
Authors: Jankowski Paul , Lee Emma R. , Embil John , Keynan Yoav , McLaren Paul J. 
Published: September 2024

ABSTRACTBackgroundBlastomycosis is a pulmonary disease caused by Blastomyces spp., a group of pathogenic dimorphic fungi endemic to a number of geographic regions, specifically Manitoba and northwestern Ontario, Canada. Immunosuppression is a major risk factor affecting disease susceptibility, yet host immunity is not well understood. Genetic immunodeficiencies can also influence disease, with variants in IL6, GATA2 and VDBP shown to influence susceptibility. Additional genetic factors in disease susceptibility and severity remain undetected. Our study seeks to identify potential genetic risk factors in a blastomycosis case–control cohort from Manitoba and northwestern Ontario, Canada.MethodsExomes from 18 blastomycosis cases and 9 controls were sequenced, variants were identified and filtered for accuracy and quality. We performed candidate gene prioritisation and variant aggregation to identify genetic associations and explored the full exome dataset.ResultsNinety‐nine genetic variants in 42 candidate genes were identified in the exome dataset. No variants associated with susceptibility were identified in a single‐variant analysis although two non‐synonymous variants in TYK2 were enriched among cases suggesting a possible role in susceptibility. Gene‐based association analysis found variants in TLR1 enriched in controls (p = 0.024) suggesting a possible protective effect. Gene cluster analysis identified genetic variants in genes of chromatin remodelling, proteasome and intraflagellar transport significantly enriched in cases (false discovery rates < 14%).ConclusionsThe findings in this study show novel associations with blastomycosis susceptibility. A better understanding of host immunity and genetic predisposition to Blastomyces infection can help to inform clinical practice for improved outcomes.