bluuebunny/crossref_metadata_2025_split huggingface dataset:
A human-specific switch of alternatively splicedAFMIDisoforms contributes toTP53mutations and tumor recurrence in hepatocellular carcinoma
Authors: Lin Kuan-Ting , Ma Wai-Kit , Scharner Juergen , Liu Yun-Ru , Krainer Adrian R. 
Published: July 2017

AbstractPre-mRNA splicing can contribute to the switch of cell identity that occurs in carcinogenesis. Here we analyze a large collection of RNA-Seq datasets and report that splicing changes in hepatocyte-specific enzymes, such asAFMIDandKHK, are associated with HCC patients’ survival and relapse. The switch ofAFMIDisoforms is an early event in HCC development, and is associated with driver mutations inTP53andARID1A. Finally, we show that the switch ofAFMIDisoforms is human-specific and not detectable in other species, including primates. The integrative analysis uncovers a mechanistic link between splicing switches,de novoNAD+biosynthesis, driver mutations, and HCC recurrence.
Chasing innovation: a pilot case study of a rhizomatic design thinking education program
Authors: Biffi Alfredo , Bissola Rita , Imperatori Barbara 
Published: July 2017

Purpose
The purpose of this paper is to illustrate and discuss the main features and key challenges of an original post-graduate education program designed according to an innovative theoretical framework promoting design thinking in a rhizomatic approach. By involving different stakeholders, the aim of this entrepreneurship education program is to disseminate rhizomatic, design-based learning competencies and thereby contribute to revitalizing a region’s socio-economic fabric.

Design/methodology/approach
Through the use of a pilot case, the paper exemplifies the application of the design thinking approach combined with the rhizomatic logic. Design thinking enables dealing with the complexity, uncertainty, and ill-defined problems that often characterize a business reality while the rhizomatic process combines the production of collective knowledge through a non-linear, complex and emergent path that nurtures innovation.

Findings
This entrepreneurship education program exemplifies a viable strategy to deal with a regional economic crisis by engaging different local actors including enterprises, local institutions, municipalities, and universities. It demonstrates the potential value of a new educational approach as a powerful lever to activate the energy of people, their competencies, relationships, shared projects, and new entrepreneurial ventures. The first edition of the program offers ideas, practices, and challenges to all stakeholders of potentially similar education projects.

Originality/value
The depicted pilot case allows us to exemplify how a design thinking framework reinterpreted on the basis of a Deleuzian rhizomatic perspective can enable developing innovation as a way of overcoming difficulties and succeeding, an essential prerequisite for many entrepreneurial organizations today.
Examining US college students’ career information sources across three decades
Authors: Zondag Marcel M. , Brink Kyle E. 
Published: July 2017

Purpose
The purpose of this paper is to examine the career information sources used by university students and identify whether the use of the various sources differs across three generational cohorts.

Design/methodology/approach
A survey was administered to 322 students majoring in food marketing and related fields at 12 US universities. The results were compared to prior survey results from 1995 to 2004.

Findings
Students continue to use many of the same sources for career information, but use them more frequently. College professors/courses were the most fruitful sources, followed closely by career fair/company visit, job/internship, and family/relatives. Although career centers and counselors were used less frequently, their use is growing. Written materials are used the least, and their use is declining.

Research limitations/implications
The sample is limited to the food and consumer packaged goods (“food/CPG”) industry. It is also limited to US college students.

Practical implications
If organizations and recruiters want to reach and attract millennial students, establishing and fostering relationships with university personnel, especially faculty, is critical. Investing in course activities (e.g. guest lectures, case studies) and industry experiences (e.g. jobs and internships) is also important.

Originality/value
This is the first study to examine the use of career information sources across generational cohorts specifically in the context of the food/CPG industry. The results are bolstered by robust samples and the time-lag design.
Planning for the redevelopment after a fire event
Authors: MacKenzie Andrew 
Published: July 2017

Purpose
The purpose of this paper is to explore the role of planners and designers in supporting residents to negotiate the challenges of rebuilding after wildfire on the urban fringe. The research seeks to understand how planning and design professionals, in providing professional services, comprehend the changing expectations of residents transitioning from emergency to the slow process of achieving a post fire normal state through the project of redesigning their homes.

Design/methodology/approach
This paper uses semi-structured interviews to examine the role of planners and designers employed to facilitate and assess, or provide design services for residents who rebuilt houses after the 2003 bushfires in Canberra, Australia’s Capital City. Narrative analysis was used to identify emerging themes based on their professional experiences during the redevelopment of the suburb.

Findings
Case analysis shows that external influences were significant contributing factors in determining the design of houses rebuilt after the fires. The goal for both the designers and residents was to design a more sustainable built form; however, this was not achieved as external social and cultural influences came into the decision-making process.

Practical implications
The paper provides a different perspective on the competing goals planners and designers face in supporting residents to rebuild after disasters such as wild fires. It highlights the changing nature of the relationship between professionals and community. In particular, the research suggests planners can play an important role as observers and facilitators of long-term change occurring in the years after wildfire. The research provides insights into how planners and building designers may better serve the community by gaining a better understanding of the changing nature of redevelopment over time.

Originality/value
The research provides a novel approach to understanding the challenges facing planners and building designers working with residents to rebuild houses after wildfire. The paper makes the case for a better understanding of the temporal dynamics and external influences affecting decision making in post disaster redevelopment of homes.
The energy efficiency and carbon footprint of temporary homes: a case study from Japan
Authors: Kuittinen Matti , Takano Atsushi 
Published: July 2017

Purpose
The purpose of this study is to investigate the energy efficiency and life cycle carbon footprint of temporary homes in Japan after the Great Eastern Tohoku Earthquake in 2011.

Design/methodology/approach
An energy simulation and life cycle assessment have been done for three alternative shelter models: prefabricated shelters, wooden log shelters and sea container shelters.

Findings
Shelter materials have a very high share of life cycle emissions because the use period of temporary homes is short. Wooden shelters perform best in the comparison. The clustering of shelters into longer buildings or on top of each other increases their energy efficiency considerably. Sea containers piled on top of each other have superb energy performance compared to other models, and they consume even less energy per household than the national average. However, there are several gaps of knowledge in the environmental assessment of temporary homes and field data from refugee camps should be collected as part of camp management.

Originality/value
The findings exemplify the impacts of the proper design of temporary homes for mitigating their energy demand and greenhouse gas emissions.
Stakeholders’ role in disaster-risk-reduction of fire occurrences in Lagos Metropolis
Authors: Alabi Adewale Segun , Adegbile Michael , Alabi Oluwadamilola , Abisuga Olatunji , Oyewole Kehinde , Oshodi Olalekan 
Published: July 2017

Purpose
Recently, frequent occurrence of fire incidences in various building types with devastating effects on human settlements have proliferated and have become of serious concern to Nigeria’s economy. Hence, there is a need to proactively address strategic weaknesses in measures directed at protecting the built environment (BE). The purpose of this paper is to examine stakeholders’ role in the frameworks on disaster risk reduction (DRR) in the context of fire hazards within Lagos metropolis. Analysis is based on findings of research carried out on vulnerability, resilience assessment and guiding principles from three recent frameworks.

Design/methodology/approach
Mixed research design was adopted using questionnaires and semi-structured interviews. In all, 165 BE professionals in the construction industry, state/federal emergency management and local/national government agencies were randomly selected.

Findings
Findings show that stakeholders believe prevention, preparedness and mitigation of disasters are the most important; however, BE professionals in the construction industry do not play active roles in the mitigation of fire risk despite wide publications on guidance for fire hazard mitigation. These stakeholders urgently need to adopt fire hazard mitigation strategies, especially in the pre-construction phase of a building’s life cycle which is identified as the most critical stage in the construction phase.

Research limitations/implications
The paper looked at fire occurrence in Lagos from the perspective of the BE with the view to fill knowledge gaps for adopting fire hazard mitigation strategies.

Originality/value
The findings brought to bear the need for stakeholders, especially BE professionals in the construction industry, to be better involved in DRR as regards fire occurrences.
Post-reforms training needs of frontline managers in Indian power distribution companies
Authors: Vishwakarma Suresh , Tyagi Ruchi 
Published: July 2017

Purpose
The purpose of this paper is to assess the training needs based on top management view point for the development of frontline managers (FLM) of Indian power distribution companies (DISCOMs).

Design/methodology/approach
DISCOMs’ top managers were interviewed to develop questionnaire items. A total of ten items were identified; the response from the middle managers and FLM were collected with the help of a questionnaire on a five-point Likert type. The Cronbach’s alpha, face and content validity of instrument were performed. The sample population was 364 based on stratified probability proportional to size (PPS) sampling. The statistical tool used for data analysis was chi square through SPSS package.

Findings
Top management of DISCOMs for developing training program emphasizes on 10 organizational items. Which when assessed with middle and FLM of DISCOM, the results indicated a disagreement between their opinions suggesting practical implications on training need analysis at these DISCOMs.

Research limitations/implications
The emphasis of top management for identifying the FLM training needs only acknowledges the work environment and customer requirements, whereas the personal and task related factors (other than customer services) affecting their performance are overlooked.

Originality/value
Reforms in the Indian power sector have been introduced only 26 years back. This study explicitly focuses on the DISCOMs at the central India. Present viewpoint of top management on the competency and training needs of their FLM. The Cronbach’s alpha and discriminant validity has been performed.
Implementation of a balanced scorecard for hybrid business models – an application for citizen renewable energy companies in Germany
Authors: Kahla Franziska 
Published: July 2017

PurposeThis paper aims to introduce strategic management tools for companies with hybrid business models, for example, those with citizen participation. These models are often used of citizen renewable energy companies that have become a main pillar of the energy sector in Germany in recent years. The strategic management tools proposed here could help to achieve most of their objectives.Design/methodology/approachIn the first step, a definition of hybrid businesses is derived by literature review, and the importance of strategic management in companies with citizen participation is discussed. In the next step, a new construct of a balanced scorecard (BSC) model is applied to citizen renewable energy companies by using survey data and previous studies.FindingsCompanies with citizen participation differ from profit-seeking companies and nonprofit organizations, and they are described by new hybrid business models. This study shows with a modification of the BSC that social or environmental aims are as important as financial ones to companies with citizen participation, which follow a double bottom line approach.Practical implicationsHybrid businesses are important for the German energy sector, and strategic management tools are needed for their continued success and competitiveness. This paper can be a starting point for the management who want to implement these tools.Originality/valueThe paper addresses a gap in the strategic management literature on companies with citizen participation. The tools developed here can be modified for other hybrid businesses.
An adaptive approach for recovering overlapping echoes in oil film thickness measurement by ultrasound
Authors: Zhang Kai , Wu Tonghai , Duan Zhihe , Meng Qingfeng , Meng Qinghu 
Published: July 2017

Purpose
For oil film thickness measurement using ultrasonic spring model, obtaining the isolated reflection from the oil film layer is the key point. While for oil film thickness measurement in thrust bearings with thin liner, the reflection from the substrate-Babbitt interface will overlap with the reflection from the oil film layer. This overlapping will render the ultrasonic spring model invalid. To obtain the isolated reflected signal from the oil film layer accurately, an adaptive method was developed to recover the overlapping echoes.

Design/methodology/approach
A genetic-algorithm-based support matching pursuit (GA-based SMP) was developed to provide the optimal echo number and initial parameters guesses automatically and efficiently. Then, the traditional expectation maximization (EM) model was used to fine tune the accurate results.

Findings
The developed method was tested using both simulated echoes and the overlapping echoes encountered in the ultrasonic oil film thickness measurement of thrust bearings. The results demonstrated that the developed method performed well on recovering overlapping echoes adaptively.

Originality/value
The work shows an adaptive method to recover the ultrasonic overlapping echoes. When used in ultrasonic oil film thickness measurement, it can help extend the application of traditional ultrasonic spring model to objects with four or more layers.
Tribological properties of beef tallow as lubricating grease
Authors: Padgurskas Juozas , Rukuiža Raimundas , Mandziuk Ihor , Kupcinskas Arturas , Prisyazhna Katerina , Grigoriev Andrei , Kavaliova Inna , Revo Sergej 
Published: July 2017

Purpose
The purpose of this paper is to report on the tribological properties of beef tallow grease and improvements therein through modification with special processing, polymeric compounds and additives.

Design/methodology/approach
Pure original beef tallow grease was used as a biological lubricating grease reference material for the tribological research. Beef tallow was modified and synthesized by adding special biological anti-oxidant additives, LZ anti-wear additives, waste polyethylene terephthalate (PET) polymer compounds and thermally processed graphite.

Findings
Rheometric measurements indicate that the beef tallow grease modification technology used in this study enables control of the synthesis process to produce lubricants with the required microstructure. Investigation results of the tribological properties of differently modified greases show that beef tallow synthesized with polymer additives efficiently operates together with anti-wear additives to reduce friction and wear. The grease compound with thermally processed graphite has good tribological properties at 300 N load levels. The critical load level of lubricating greases could be significantly increased through the use of anti-wear additives and thermally processed graphite.

Originality/value
Investigation results of the tribological properties of differently modified beef tallow greases show that beef tallow synthesized with polymer additives efficiently operates together with anti-wear additives to reduce friction and wear. The critical load level of lubricating beef tallow greases could be significantly increased using anti-wear additives and thermally processed graphite.
Genes important for survival or reproduction in Varroa destructor identified by RNAi
Authors: Huang Zachary Y. , Bian Guowu , Xi Zhiyong , Xie Xianbing 
Published: July 2017

AbstractThe Varroa mite, (Varroa destructor), is the worst threat to honey bee health worldwide. To explore the possibility of using RNA interference to control this pest, we determined the effects of knocking down various genes on Varroa mite survival and reproduction. Double‐stranded RNA (dsRNA) of six candidate genes (Da, Pros26S, RpL8, RpL11, RpP0 and RpS13) were synthesized and each injected into Varroa mites, then mite survival and reproduction were assessed. Injection of dsRNA for Da (Daughterless) and Pros26S (Gene for proteasome 26S subunit adenosine triphosphatase) caused a significant reduction in mite survival, with 3.57% ± 1.94% and 30.03% ± 11.43% mites surviving at 72 h post‐injection (hpi), respectively. Control mites injected with green fluorescent protein (GFP)‐dsRNA showed survival rates of 81.95% ± 5.03% and 82.36 ± 2.81%, respectively. Injections of dsRNA for four other genes (RpL8, RpL11, RpP0 and RpS13) did not affect survival significantly, enabling us to assess their effect on Varroa mite reproduction. The number of female offspring per mite was significantly reduced for mites injected with dsRNA of each of these four genes compared to their GFP‐dsRNA controls. Knockdown of the target genes was verified by real‐time polymerase chain reaction for two genes important for reproduction (RpL8, RpL11) and one gene important for survival (Pros26S). In conclusion, through RNA interference, we have discovered two genes important for mite survival and four genes important for mite reproduction. These genes could be explored as possible targets for the control of Varroa destructor in the future.
Delayed postoperative diet is associated with a greater incidence of prolonged postoperative ileus and longer stay in hospital for patients undergoing gastrointestinal surgery
Authors: Rees Joanna , Bobridge Kelly , Cash Catherine , Lyons‐Wall Philippa , Allan Rebecca , Coombes Jacqui 
Published: July 2017

AimRecent evidence favours a move away from delaying postoperative nutrition towards early feeding practices for better patient outcomes after gastrointestinal surgery. The aim of the present study was to investigate postoperative diet progression and patient outcomes in a secondary hospital with a view to inform future practice.MethodsThis was a retrospective study of gastrointestinal surgery patients (n = 69) at a Western Australian general hospital. Demographic data and outcomes were collected from patient records and included presence or absence of prolonged postoperative ileus, length of stay in hospital, days on minimal nutrition and days until first flatus or stool.ResultsA significant positive association was observed between number of days a patient remained on minimal nutrition and length of stay in the overall group (r = 0.66, P < 0.01). Patients who developed prolonged postoperative ileus (n = 18, 26%) had a greater number of days on minimal nutrition (20.0 vs 8.0 days, P < 0.01), longer stay in hospital (15.0 vs 8.0 days, P < 0.01) and increased number of days to first flatus or stool (4.0 vs 2.4 days, P < 0.01) compared with those who did not develop prolonged postoperative ileus (n = 51, 74%).ConclusionsThis retrospective study of current practice in a secondary‐care general hospital highlights the gap between traditional care and the improved outcomes reported in the literature when early feeding practices are adopted after GI surgery. Further investigation of barriers and enablers is necessary to provide insight into developing the most appropriate strategy to achieve this.
Accuracy and confidence of allied health assistants administering the subjective global assessment on inpatients in a rural setting: a preliminary feasibility study
Authors: Newman Cristal S. , Cornwell Petrea L. , Young Adrienne M. , Ward Elizabeth C. , Mcerlain Annmarie L. 
Published: July 2017

AimMalnutrition has a significant impact on patient outcomes and duration of inpatient stay. However, conducting timely nutrition assessments can be challenging for rural dietitians. A solution could be for allied health assistants (AHAs) to assist with these assessments. The present study aimed to assess the accuracy and confidence of AHAs trained to conduct the subjective global assessment (SGA) compared with dietitians.MethodsA non‐inferiority study design was adopted. Forty‐five adult inpatients admitted to a rural and remote health service were assessed independently by both a trained AHA and dietitian within 24 hours. The order of assessment was randomised, with the second assessor blind to the outcome of the initial SGA. Levels of agreement were examined using kappa and percent exact agreement (PEA; set a priori at ≥80%). Rater confidence after each assessment was assessed using a 10‐point scale.ResultsAgreement for overall SGA ratings was high (kappa = 0.84; PEA 84.4%). PEA for individual sub‐components of the SGA ranged from 66.4 to 86.7%. Where discrepancies were identified in global SGA ratings, AHAs provided a more severe rating of malnutrition than dietitians. AHAs reported significantly lower confidence than dietitians (t = 4.49, P < 0.001), although mean confidence for both groups was quite high (AHA=7.5, dietitians = 9.0).ConclusionsTrained AHAs completed the SGA with similar accuracy to dietitians. Using AHAs may help facilitate timely nutrition assessment in rural health services when a dietitian is not physically present. Further investigation is required to determine the benefits of incorporating this extended role into rural and remote health‐care services.