bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotic proctectomy for rectal cancer: analysis of 71 patients from a single institution
Authors: Spanheimer Philip M. , Armstrong John G. , Fu Sunyang , Liao Junlin , Regenbogen Scott E. , Byrn John C. 
Published: June 2017

AbstractBackgroundDespite increasing use of robotic surgery for rectal cancer, few series have been published from the practice of generalizable US surgeons.MethodsA retrospective chart review was performed for 71 consecutive patients who underwent robotic low anterior resection (LAR) or abdominoperineal resection (APR) for rectal adenocarcinoma between 2010 and 2014.Results46 LARs (65%) and 25 APRs (35%) were identified. Median procedure time was 219 minutes (IQR 184–275) and mean blood loss 164.9 cc (SD 155.9 cc). Radial margin was negative in 70/71 (99%) patients. Total mesorectal excision integrity was complete/near complete in 38/39 (97%) of graded specimens. A mean of 16.8 (SD+/− 8.9) lymph nodes were retrieved. At median follow‐up of 21.9 months, there were no local recurrences.ConclusionsRobotic proctectomy for rectal cancer was introduced into typical colorectal surgery practice by a single surgeon, with a low conversion rate, low complication rate, and satisfactory oncologic outcomes.
Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease
Authors: Zufferey Valérie , Donati Alessia , Popp Julius , Meuli Reto , Rossier Jérôme , Frackowiak Richard , Draganski Bogdan , von Gunten Armin , Kherif Ferath 
Published: June 2017

AbstractIntroductionCertain personality traits are associated with higher risk of Alzheimer's disease, similar to cognitive impairment. The identification of biological markers associated with personality in mild cognitive impairment could advance the early detection of Alzheimer's disease.MethodsWe used hierarchical multivariate linear models to quantify the interaction between personality traits, state of cognitive impairment, and MRI biomarkers (gray matter brain volume, gray matter mean water diffusion) in the medial temporal lobe (MTL).ResultsOver and above a main effect of cognitive state, the multivariate linear model showed significant interaction between cognitive state and personality traits predicting MTL abnormality. The interaction effect was mainly driven by neuroticism and its facets (anxiety, depression, and stress) and was associated with right‐left asymmetry and an anterior to posterior gradient in the MTL.DiscussionOur results support the hypothesis that personality traits can alter the vulnerability and pathoplasticity of disease and therefore modulate related biomarker expression.
Multilingual extension and evaluation of a poetry generator
Authors: OLIVEIRA HUGO GONÇALO , HERVÁS RAQUEL , DÍAZ ALBERTO , GERVÁS PABLO 
Published: June 2017

AbstractPoetry generation is a specific kind of natural language generation where several sources of knowledge are typically exploited to handle features on different levels, such as syntax, semantics, form or aesthetics. But although this task has been addressed by several researchers, and targeted different languages, all known systems have focused on a limited purpose and a single language. This article describes the effort of adapting the same architecture to generate poetry in three different languages – Portuguese, Spanish and English. An existing architecture is first described and complemented with the adaptations required for each language, including the linguistic resources used for handling morphology, syntax, semantics and metric scansion. An automatic evaluation was designed in such a way that it would be applicable to the target languages. It covered three relevant aspects of the generated poems, namely: the presence of poetic features, the variation of the linguistic structure and the semantic connection to a given topic. The automatic measures applied for the second and third aspect can be seen as novel in the evaluation of poetry. Overall, poems were successfully generated in the three languages addressed. Despite minor differences in different languages or seed words, poems revealed to have a regular metre, frequent rhymes, to exhibit an interesting degree of variation, and to be semantically-associated with the initially given seeds.
Revised practical guidance for first responders managing the dead after disasters
Authors: Ellingham Sarah , Cordner Stephen , Tidball-Binz Morris 
Published: June 2017

AbstractThe proper and dignified management of the dead is one of the three pillars of the humanitarian response to disasters, along with the rescue and care of survivors and the provision of essential services. First launched in 2006, the widely used publication Management of Dead Bodies after Disasters: A Field Manual for First Responders offers practical and easy-to-follow guidelines. It has become the go-to guide not only for non-experts confronted with dead bodies in the aftermath of a catastrophe, but also for those responsible for disaster planning and preparedness in countries with well-developed forensic services. Ten years after the publication of the 2006 Manual, a revised edition has been released. The inclusion of a decade of experience in its field implementation, as well as the incorporation of recent scientific developments in mass fatality management, makes the revised Manual an invaluable resource for first responders confronted with the realities of dead body management following a disaster.
Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial–mesenchymal transition and metastasis
Authors: Zhang Ting , Yin Ping , Zhang Zichen , Xu Banglao , Che Di , Dai Zhiyu , Dong Chang , Jiang Ping , Hong Honghai , Yang Zhonghan , Zhou Ti , Shao Jianyong , Xu Zumin , Yang Xia , Gao Guoquan 
Published: June 2017

AbstractDistant metastasis is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure while epithelial–mesenchymal transition (EMT) is the critical process of NPC invasion and metastasis. However, tumor-suppressor genes involved in the EMT and metastasis of NPC have not been explored clearly compared with the oncogenes. In the present study, the expression of pigment epithelium-derived factor (PEDF), a potent endogenous antitumor factor, was diminished in human NPC tissues and associated with clinicopathological and EMT features. The knockdown of PEDF induced EMT in lower metastatic NPC cell lines and overexpression of PEDF restored epithelial phenotype in higher metastatic NPC cell lines with typical EMT. The inhibition of PEDF mediated NPC cell spontaneous metastasis in vivo. LRP6/GSK3β/β-catenin signal pathway rather than AKT/GSK3β pathway was involved in the effects of PEDF on EMT. The expression of PEDF was directly downregulated by elevated miR-320c in NPC. In conclusion, our findings indicate for the first time that PEDF functions as tumor-suppressor gene in the occurrence of EMT and metastasis in NPC. PEDF could serve as a promising candidate for NPC diagnosis, prognosis and treatment.
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth
Authors: Shi Yu , Ping Yi-Fang , Zhou Wenchao , He Zhi-Cheng , Chen Cong , Bian Bai-Shi-Jiao , Zhang Lin , Chen Lu , Lan Xun , Zhang Xian-Chao , Zhou Kai , Liu Qing , Long Hua , Fu Ti-Wei , Zhang Xiao-Ning , Cao Mian-Fu , Huang Zhi , Fang Xiaoguang , Wang Xiuxing , Feng Hua , Yao Xiao-Hong , Yu Shi-Cang , Cui You-Hong , Zhang Xia , Rich Jeremy N , Bao Shideng , Bian Xiu-Wu 
Published: June 2017

AbstractIntense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN–PTPRZ1 paracrine signalling. PTN expression correlates with infiltration of CD11b+/CD163+ TAMs and poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLCs) promoted GSC-driven tumour growth, but silencing PTN expression in MLCs mitigated their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSCs and also predicts GBM poor prognosis. Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential. Moreover, blocking the PTN–PTPRZ1 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged animal survival. Our study uncovered a critical molecular crosstalk between TAMs and GSCs through the PTN–PTPRZ1 paracrine signalling to support GBM malignant growth, indicating that targeting this signalling axis may have therapeutic potential.
Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development
Authors: Quinn Malgorzata E. , Goh Qingnian , Kurosaka Mitsutoshi , Gamage Dilani G. , Petrany Michael J. , Prasad Vikram , Millay Douglas P. 
Published: June 2017

AbstractDespite the importance of cell fusion for mammalian development and physiology, the factors critical for this process remain to be fully defined, which has severely limited our ability to reconstitute cell fusion. Myomaker (Tmem8c) is a muscle-specific protein required for myoblast fusion. Expression of myomaker in fibroblasts drives their fusion with myoblasts, but not with other myomaker-expressing fibroblasts, highlighting the requirement of additional myoblast-derived factors for fusion. Here we show that Gm7325, which we name myomerger, induces the fusion of myomaker-expressing fibroblasts. Thus, myomaker and myomerger together confer fusogenic activity to otherwise non-fusogenic cells. Myomerger is skeletal muscle-specific and genetic deletion in mice results in a paucity of muscle fibres demonstrating its requirement for normal muscle formation. Myomerger deficient myocytes differentiate and harbour organized sarcomeres but are fusion-incompetent. Our findings identify myomerger as a fundamental myoblast fusion protein and establish a system that begins to reconstitute mammalian cell fusion.
miR-19a contributes to gefitinib resistance and epithelial mesenchymal transition in non-small cell lung cancer cells by targeting c-Met
Authors: Cao Xiaonian , Lai Senyan , Hu Fayong , Li Guodong , Wang Guihua , Luo Xuelai , Fu Xiangning , Hu Junbo 
Published: June 2017

AbstractGefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is used as a first-line treatment for advanced non-small cell lung cancer (NSCLC). However, most NSCLC patients inevitably develop gefitinib resistance, and the mechanisms underlying this resistance are not fully understood. In this study, we show that miR-19a is significantly down-regulated in gefitinib-resistant NSCLC cell lines compared with gefitinib-sensitive cell lines. In addition, the down-regulation of miR-19a suppressed the expression of epithelial markers but induced the expression levels of mesenchymal markers. A mechanistic analysis revealed that miR-19a regulated c-Met expression by directly targeting the c-Met 3′UTR. Overexpression of miR-19a decreased c-Met expression and re-sensitized gefitinib-resistant NSCLC cells in vitro and in vivo. Consistent with the in vitro findings, the miR-19a serum level was significantly decreased in NSCLC patients with acquired gefitinib resistance compared with the level observed prior to the acquisition of resistance in each patient, indicating that miR-19a expression may be a valuable biomarker for the prediction of acquired gefitinib resistance in a clinical setting. Our data demonstrate that the miR-19a/c-Met pathway plays a critical role in acquired resistance to gefitinib and that the manipulation of miR-19a might provide a therapeutic strategy for overcoming acquired gefitinib resistance.
Synthesis method of asymmetric gold particles
Authors: Jun Bong-Hyun , Murata Michael , Hahm Eunil , Lee Luke P. 
Published: June 2017

AbstractAsymmetric particles can exhibit unique properties. However, reported synthesis methods for asymmetric particles hinder their application because these methods have a limited scale and lack the ability to afford particles of varied shapes. Herein, we report a novel synthetic method which has the potential to produce large quantities of asymmetric particles. Asymmetric rose-shaped gold particles were fabricated as a proof of concept experiment. First, silica nanoparticles (NPs) were bound to a hydrophobic micro-sized polymer containing 2-chlorotritylchloride linkers (2-CTC resin). Then, half-planar gold particles with rose-shaped and polyhedral structures were prepared on the silica particles on the 2-CTC resin. Particle size was controlled by the concentration of the gold source. The asymmetric particles were easily cleaved from the resin without aggregation. We confirmed that gold was grown on the silica NPs. This facile method for synthesizing asymmetric particles has great potential for materials science.
White matter microstructural changes are related to cognitive dysfunction in essential tremor
Authors: Benito-León Julián , Mato-Abad Virginia , Louis Elan D. , Hernández-Tamames Juan Antonio , Álvarez-Linera Juan , Bermejo-Pareja Félix , Domingo-Santos Ángela , Collado Luis , Romero Juan Pablo 
Published: June 2017

AbstractDiffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of white matter changes with scores obtained from a detailed neuropsychological assessment were subsequently examined. ET patients demonstrated increases in MD in the bilateral posterior corona radiata, bilateral superior longitudinal fasciculus, bilateral fornix (cres)/stria terminalis, genu and splenium of the corpus callosum, bilateral anterior and posterior limbs of internal capsule, bilateral retrolenticular region part of internal capsule, and left posterior thalamic radiation. Except for the genu of the corpus callosum, an increase in AD values was also found in these same tracts. Furthermore, increased MD and AD values in different white matter areas was negatively correlated with performance on language and verbal memory and positively with visuospatial ability. These correlations suggest that white matter changes might be involved in the pathogenesis of cognitive deficits in ET.
Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol Succinate (TPGS) Mixed Micelles for Targeting Drug Delivery across The Blood Brain Barrier
Authors: Meng Xin , Liu Jiansheng , Yu Xiangrong , Li Jiajia , Lu Xiaotong , Shen Teng 
Published: June 2017

AbstractA novel polymeric mixed micelle composed of Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) was developed to improve the delivery of fluorescent dyes and protein across the blood brain barrier (BBB). Rhodamine 123 (Rho123) and DiR loaded mixed micelles, composed of Pluronic F127 and TPGS with proportion of 4:1 (FT), were prepared by thin-film hydration, and β-galactosidase (β-Gal) loaded FT mixed micelles were prepared by self-assembly. The brain-targeted capability of FT mixed micelles were evaluated both in vitro and in vivo. The FT mixed micelles showed that a average particle size of 20.03 nm, and a low CMC of 0.0031% in water. The in vitro release of Rho123 from Rho123 loaded FT mixed micelles (FT/Rho123) presented a sustained-release property. FT/Rho123 also showed higher efficiency for the accumulation in brain capillary endothelial cells (BCECs) and brain tissues. β-Gal, a model protein, was also delivered and accumulated efficiently in the brain by spontaneous loading in the FT mixed micelles. Therefore, the results indicated that F127/TPGS mixed micelles may be considered as an effective nanocarrier for the brain-targeted delivery of diagnostic and therapeutic drugs.
GGNBP2 is necessary for testis morphology and sperm development
Authors: Chen Anqi , Li Jixi , Song Lesheng , Ji Chaoneng , Böing Marion , Chen Jinzhong , Brand-Saberi Beate 
Published: June 2017

AbstractGametogenetin Binding Protein 2 (GGNBP2) was identified as a tumor suppressor and verified as such by several studies. GGNBP2 has also been reported to be essential for pregnancy maintenance via regulation of trophoblast stem cells. Gametogenetin (GGN) is a testicular germ cell-specific gene expressed in adult testes. As a potential GGN1-interacting protein, the role of GGNBP2 in spermatogenesis has not yet been clarified. We generated heterozygous GGNBP2 knockout mice and bred them by intercrossing. We found that among the offspring, homozygous GGNBP2 knockout (KO) mice were present in severely reduced numbers. The GGNBP2 KO pups developed normally, but the male siblings showed dramatically reduced fertility. In these male homozygous GGNBP2 KO mice, the only pathological finding was abnormal morphology of the testes and absence of spermatozoa. In addition, increased apoptosis was observed in the testes of GGNBP2 KO mice. SOX9 staining revealed that SOX9-positive Sertoli cells were absent in the seminiferous tubules. In homozygous mice, proliferating cell nuclear antigen (PCNA)-positive cells were localized in the lumen of the convoluted seminiferous tubules. These results suggest that GGNBP2 plays a key role in spermatogenesis by affecting the morphology and function of SOX9-positive Sertoli cells.
Low phase noise oscillator based on complementary split‐ring resonators loaded quarter‐mode circular SIW cavity
Authors: Xu Jie , Cui Yinjie , Xu Zhengbin , Guo Jian , Qian Cheng , Li Wenyuan 
Published: June 2017

A high Q‐factor substrate integrated waveguide (SIW) cavity resonator and its application of X‐band low phase noise oscillator is proposed. Complementary split‐ring resonators are used to improve the Q‐factor of the proposed resonator. The size of the resonator is reduced by using quarter‐mode circular SIW cavity. The oscillator based on the proposed SIW cavity resonator can be easily designed and tested. Measured results demonstrate an output frequency of 10.11 GHz and a phase noise of −108.7 dBc/Hz at 100 kHz offset. The oscillator is also able to deliver an output power of 4.6 dBm and harmonic rejection of better than 30 dBc. The proposed oscillator is suitable for low‐cost high‐frequency systems.
Psychology of the Facelift Patient
Authors: Adamson Peter , Sarcu David 
Published: June 2017

AbstractThis paper presents an extensive literature review of the psychology of facelift patients as it has evolved over the past 50 years. Earlier studies revealed significant levels of pre and perioperative depression. Facelift patients generally exhibit emotional and social concerns about facial appearance that are higher than the general population. Many are undergoing midlife situational stresses and may lack the positive characteristics to deal with them. The most common diagnoses seen include depression, impulsivity, unstable personality, and passive dependence, albeit not necessarily serious. Improvement in body image is the major driver for surgery. Characteristics of female patients as defined by their age are described. These include the younger emotionally dependent group, the worker group of middle age, and the older grief group. Male patients are seen to have a higher level of psychological dysfunction, but a higher improvement in postoperative quality of life. Motivations for surgery include increasing self-esteem, making new friends, improving relationships, and getting better jobs. Overall patient satisfaction is more than 95%, with improvement seen in positive changes in their life, increased self-confidence and self-esteem, decreased self-consciousness about their appearance, and overall improvement in quality of life. Postoperative psychological reactions are seen in about half the patients, these primarily being anxiety and depression of varying degrees. Predictors of patient satisfaction include the desire for self-image improvement in contradistinction to a change in life situation. Negative predictors include male sex, young age, unrealistic expectations, relationship disturbances, and preexisting psychological pathology. The importance of good patient selection in achieving a satisfied patient is outlined and emphasized.
Therapeutic Ultrasound and Prostate Cancer
Authors: Sundaram Karthik , Chang Sam , Penson David , Arora Sandeep 
Published: June 2017

AbstractTherapeutic ultrasound approaches including high-intensity focused ultrasound (HIFU) are emerging as popular minimally invasive alternative treatments for localized, low-to-intermediate risk prostate cancer. FDA approval was recently granted for two ultrasound-guided HIFU devices. Clinical trials for devices using MRI guidance are ongoing. The current level of evidence for whole-gland ultrasound ablation suggests that its clinical efficacy and adverse event rates including erectile dysfunction and urinary incontinence are similar to current definitive therapies such as radical prostatectomy and external-beam radiotherapy. Short-term data suggest that more focal therapy could reduce the rates of adverse events.
Surgical Anatomy for Facelift
Authors: Batniji Rami 
Published: June 2017

AbstractKnowledge of surgical anatomy is of paramount importance during surgical dissection for facelift surgery, regardless of the type of facelift procedure performed. This article reviews the relevant surgical anatomy for facelift, including the superficial musculoaponeurotic system (SMAS), and course of the facial nerve relative to the SMAS, zygomatic arch, and mandible. Also, this article reviews the various retaining ligaments, and some types of facelift procedures recommend release of these ligaments to achieve a more effective aesthetic result.
Bioactive Bafilomycins and a New N-Arylpyrazinone Derivative from Marine-derived Streptomyces sp. HZP-2216E
Authors: Zhang Zhizhen , Chen Lu , Zhang Xiufang , Liang Ying , Anjum Komal , Chen Lei , Lian Xiao-Yuan 
Published: June 2017

AbstractA MeOH extract prepared from culture of an actinomycete Streptomyces sp. HZP-2216E isolated from marine green algae Ulva pertusa was found to significantly inhibit proliferation of human glioma cells. Two different media were applied to culture this marine actinomycete, which produced two new compounds of 23-O-butyrylbafilomycin D and streptoarylpyrazinone A, together with known bafilomycin D, 9-hydroxybafilomycin D, and bafilomycin A1. Structures of new compounds were determined by extensive NMR spectroscopic analyses and HRESIMS data. Bioactive assay indicated that all isolated bafilomycins significantly inhibited the proliferation of different glioma cell lines and the growth of methicillin-resistant Staphylococcus aureus with 23-O-butyrylbafilomycin D as the most active compound. Streptoarylpyrazinone A is a new N-arylpyrazinone derivative existing as a zwitterion, and this type of compounds was rarely found from natural resources.