bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potensi Eugenol Fraksi Etil Asetat Bunga Cengkeh terhadap Proliferasi Kanker Serviks (HeLa Cell Line)
Authors: Pratama Fajri Rahendra , Sari Annisa Permata , Susanti Aprilia , Syakira Hasya , Salsabila Amilia , Arisanty Dessy 
Published: September 2024

<p>Cervix cancer, also known as cervical cancer, is a type of cancer that is caused mainly by oncogenic Human Papillomavirus (HPV), which attacks the cervix. One of the plants that can be used in medicine is clove. <strong>Objective</strong>: To analyzed the effect of a fraction of ethyl acetate eugenol of clove flower for the proliferation and migration of HeLa cells. <strong>Methods</strong>: This was an in vitro experiment. Ethyl acetate fraction was tested in vitro with the MTT Assay method. A scratch Assay is done to determine the migratory power of cancer cells to Trypan Blue to see (dead cells/living cells). Data collection techniques were carried out using experimental observation techniques. The data obtained in the MTT test is the percentage of inhibited HeLa cells. Scratch Assay results were analyzed with ImageJ software and the Trypan Blue method using the TC10 tool. <strong>Results</strong>: The MTT Assay test obtained an IC50 value of 24.51 µg/ml, the average migration of treatment cells 303 and the average control group 715 cells. The number of proliferating treatments 6.14 x 105 and control 12.1 x 105. <strong>Conclusion:</strong> Based on its potential, clove flower can be a candidate for cervical cancer cell therapy (HeLa Cell Line) in the future.</p><p><strong>Keywords</strong>: anti-cervical cancer, cervical cancer, cell proliferation, MTT assay, scratch assay </p>
Ultrasonographic Evaluation of Medial Meniscal Extrusion During Common Orthopedic Physical Therapy Examination Procedures: An Observational Study
Authors: Savage Nathan J. , Bell-Linnear Kierra , Heston Daniel , Smith Paul , Sparks Kaitlyn , Ward Lance 
Published: September 2024

OBJECTIVE: To compare medial meniscal extrusion during supine knee extension overpressure and standing using ultrasound imaging. DESIGN: Cross-sectional repeated measures. METHODS: Thirty-four participants contributed 63 knees that were examined in the following positions: supine relaxed, during supine knee extension overpressure, and during standing. The primary outcome was meniscal extrusion measured using ultrasound imaging. RESULTS: Repeated-measures analysis of variance comparing meniscal extrusion across positions found significant within-group (F = 80.9, df = 3, P = .000) and between-group (F = 17.9, df = 1, P = .000) differences. There were no significant differences between knee extension overpressure and standing (F = .397, df = 2, P = .643) or interaction between age category and position examined (F = .276, df = 3, P = .821). Additional analyses revealed no association between meniscal extrusion and sex, race/ethnicity, or knee examined and weak associations between body mass index (BMI) and position examined (r = .434-.507). CONCLUSION: We found that supine knee extension overpressure produced comparable meniscal extrusion as standing, which may be clinically meaningful because some patients with knee pain cannot be reliably or safely examined in standing. JOSPT Open 2024;2(2):134-140. Epub 8 January 2024. doi:10.2519/josptopen.2024.0918
Patient Factors Associated With Treatment Effect of Manual Therapy: A Scoping Review
Authors: Keter Damian , Griswold David , Learman Kenneth , Cook Chad E. 
Published: September 2024

OBJECTIVES: To identify the association between pain phenotypic variables and manual therapy (MT) pain outcomes. DESIGN: Scoping review. LITERATURE SEARCH: The databases MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library, and Physiotherapy Evidence Database (PEDro) were searched on November 3, 2022. STUDY SELECTION CRITERIA: Studies investigating the strength of association between patient variables and MT pain outcomes. Variables included psychosocial factors (depression, anxiety, kinesiophobia/fear, catastrophizing, patient expectations), sleep factors (sleep and fatigue), initial pain qualities (intensity, symptoms duration, variability, sensitivity, irritability), endogenously driven modifications in pain sensitivity or presentation (quantitative sensory testing, temporal summation, conditioned pain modulation), and clinical response to analgesic challenge. RESULTS: Fifty studies were included for review. We identified no to moderate associations between variables and pain outcomes, and significant variability in the number of studies performed for each variable. Baseline pain characteristics and analgesic response to MT challenge had the strongest association with MT pain outcomes. CONCLUSIONS: We found associations between patient psychological status, sleep/fatigue characteristics, baseline pain characteristics, and ability to achieve early clinical analgesia with MT pain outcomes. We propose the strength of this association may increase with clustering these variables into patient subgroups (phenotyping). Clinicians should appreciate the moderating effect of these factors on MT pain outcomes. Future studies should record phenotypic factors at baseline, and develop patient subgroups for more precise application of MT toward those who are likely to benefit from it. JOSPT Open 2024;2(2):82-98. Epub 14 February 2024. doi:10.2519/josptopen.2024.1128
Relationship between Intercondylar Width and Intermolar Distance – A Radiographic Study
Authors: Kapoor Aditya , Gupta Rupesh , Sinha Monika , Beri Radhika , Abhishek N 
Published: September 2024

Objectives
To study the relationship between intercondylar width and intermolar distance in dentulous patients, the result of which may be applied to edentulous patients for teeth setting with maxillary first molar in focus.

Material and Methods
Sixty subjects consisting of 30 males and 30 females were selected, and maxillary impressions were made, followed by making study models; the intermolar distance was measured by marking the mesiobuccal cusp of maxillary molars and transferring the same for measurement. The subjects were then subjected to reverse Towne view (open mouth) and intercondylar width was measured between the exterior most points of both condyles on the X-ray film. The ratio between intercondylar width and intermolar distance was measured. The values were also subjected to statistical analysis.

Results
A high correlation existed between Intercondylar Width and intermolar distance in the dentulous patients. The intercondylar width, intermolar distance, and the ratio between intercondylar width and intermolar distance were higher in males than females.

Conclusion
Intercondylar width and intermolar distance were significantly correlated. Intercondylar width, intermolar distance, and the ratio between them were more in males than females.
A comparative mixed-method study of flipped classroom and traditional lecture for teaching rational drug prescription among undergraduates in pharmacology
Authors: S Jitha , Thomas Scaria P. 
Published: September 2024

Objectives:
Rational drug prescription is a very important competency an Indian Medical Graduate (IMG) should acquire during his undergraduate training. Irrational prescriptions lead to drug resistance, adverse drug reactions (ADRs) and drug interactions. The study was aimed to determine the effectiveness of flipped classroom compared to lecture class in teaching rational drug prescription and to compare the perception of students about either methods.

Materials and Methods:
This was a prospective interventional mixed – method study where students were pseudo-randomised to either Traditional Lecture (TL) or Flipped Classroom (FC) based on the date of their academic session. For the study purpose, 250 phase 2 MBBS students in Pharmacology were divided into two groups. Allocation into 2 groups was done by lot method one week before the scheduled class so that the online study materials could be sent to the students belonging to the flipped classroom method in the form of case scenarios and videos.

Results:
A total of 198 students participated in the study with 103 in the TL group and 95 in the FC group. Acquisition of higher order cognitive skills like application and analysis was assessed by measuring an academic score obtained from a series of exercises on rational prescription for given clinical scenarios. The academic score of the TL group (5.99 ± 2.34) vs FC group (5.59 ± 1.39 ) thus obtained was not statistically significant p > 0.05, Effect size- 0.08.

Conclusion:
A questionnaire -based assessment of students’ perceptions of TL and FC showed a statistically significant difference in favour of FC in terms of their perceptions to improve academic scores, generate peer-interaction, facilitate team- work and improve teacher- student interaction.
Numerical method for solving the problem of rational location of technical means of traffic management
Authors: Арутюнян М.А. 
Published: September 2024

В статье представлен один из полученных автором научных результатов в ходе проводимого диссертационного исследования - комбинированный численный метод для решения задачи рационального размещения технических средств организации дорожного движения, основанный на использовании метода градиентного спуска совместно с методом Ньютона-Рафсона. Поднята одна из актуальных проблем развития современного города, заключающаяся в формировании удобной и безопасной дорожно-транспортной инфраструктуры. По данным статистики, в Российской Федерации ежегодно почти 20 % от всего количества дорожно-транспортных происшествий приходится на наезды на пешеходов вне пешеходных переходов. В качестве одного из решений рассматриваемой проблемы предложена установка технических средств организации дорожного движения, в частности, пешеходных переходов на тех улицах, на которых они расположены либо нерационально, либо отсутствуют вовсе. Разработана математическая модель рационального размещения технических средств организации дорожного движения и предложен численный метод ее решения. Отмечено, что предложенный автором комбинированный численный метод позволяет быстро и точно находить оптимальные параметры для разработанной математической модели, что способствует улучшению ее производительности и точности. Обобщено, что совместное применение рассмотренных численных методов является достаточно эффективным способом решения поставленной задачи.
The article presents one of the scientific results obtained by the author during his dissertation research - a combined numerical method for solving the problem of rational placement of technical means of traffic management, based on the use of the gradient descent method together with the Newton-Raphson method. One of the pressing problems of the development of a modern city is raised, which is the formation of a convenient and safe road and transport infrastructure. According to statistics, in the Russian Federation every year almost 20% of the total number of road accidents occur in collisions with pedestrians outside pedestrian crossings. As one of the solutions to the problem under consideration, it is proposed to install technical means of organizing traffic, in particular pedestrian crossings, on those streets on which they are either irrationally located or absent altogether. A mathematical model for the rational placement of technical means of traffic management has been developed and a numerical method for its solution has been proposed. It is noted that the combined numerical method proposed by the author allows one to quickly and accurately find the optimal parameters for the developed mathematical model, which helps to improve its performance and accuracy. It is generalized that the joint application of the considered numerical methods is a fairly effective way to solve the problem.
Analisis Struktur Terbaik Neural Network dengan Algoritma Backpropagation dalam Memprediksi Indeks Kandungan Sulfida (SO2) di Ibu Kota Jakarta
Authors: Kurniasari Dian , Rafdiono M Naufal Ammar , Warsono Warsono 
Published: September 2024

Polusi udara merupakan masalah lingkungan yang umum terjadi di kota-kota besar di tanah air, tidak terkecuali Ibu Kota Jakarta. Tingginya jumlah penduduk di Jakarta menyebabkan konsentrasi polusi udara semakin tinggi karena peningkatan jumlah kendaraan. Kondisi ini diperburuk dengan banyaknya limbah yang dihasilkan oleh pabrik dari berbagai industri. Sulfida (SO2) merupakan salah satu polutan dengan konsentrasi tertinggi di Jakarta dengan total beban emisi sebesar 19.7 kton. Oleh karena itu, prediksi indeks kandungan SO2, merupakan isu penelitian yang penting karena zat SO2 dapat berdampak terhadap berbagai faktor, seperti lingkungan, pertanian, dan kesehatan. Tujuan dari penelitian ini adalah menemukan model terbaik dalam melakukan prediksi SO2 di Jakarta menggunakan Artificial Neural Network (ANN). Jenis algoritma ANN yang digunakan adalah backpropagation. Lebih lanjut, model prediksi dibangun dan dibandingkan berdasarkan tiga fungsi aktivasi dan skema pembagian data yang berbeda untuk memperoleh struktur atau arsitektur model ideal dengan tujuan mengoptimalkan hasil prediksi. Model dievaluasi menggunakan nilai Mean Absolute Percentage Error (MAPE) terkecil. Hasil penelitian menunjukkan bahwa model terbaik untuk prediksi indeks kandungan SO2 adalah model yang menerapkan fungsi aktivasi Tanh dengan skema pembagian data 90% data pelatihan dan 10% data pengujian. Model tersebut memperoleh nilai MAPE sebesar 15.87412%, dan akurasi sebesar 84.12588%. Hal ini mengindikasikan bahwa model memiliki tingkat akurasi yang cukup baik dalam memprediksi indeks kandungan SO2 di Ibu Kota Jakarta dan dapat dijadikan sebagai pendekatan alternatif dalam meningkatkan efektivitas pengendalian SO2.
Pola Penerapan Merdeka Belajar pada Pembelajaran IPS dalam Menanamkan Sikap Sosial Peserta Didik di MTsN 1 Kota Payakumbuh
Authors: Suci Nurhariani 
Published: September 2024

<p>Penelitian ini membahas perihal pola penerapan merdeka belajar pada pembelajaran ilmu pengentahuan sosial dalam menanamkan sikap sosial peserta didik di MTsN 1 Kota Payakumbuh menggunakan rumusan masalah: 1. Bagaimana pola penerapan merdeka belajar pada pembelajaran ilmu pengetahuan sosial dalam menanamkan sikap sosial di MTsN 1 Kota Payakumbuh. 2. Bagaimana menanamkan sikap sosial peserta didik pada pembelajaran IPS di MTsN 1 Kota Payakumbuh. Jenis penelitian yang digunakan adalah penelitian naratif kualitatif yang sering dianggap model penelitian naturalistik karena penelitiannya dilakukan dalam kondisi alamiah, lalu pendekatan yang dilakukan menggunakan menggunakan pendekatan pedagogik, kemudian data tadi dikumpul menggunakan cara observasi, wawancara, serta dokumentasi. Adapun instrumen menjadi suatu alat yang dipergunakan untuk mengukur kenyataan dalam penelitian dimana instrumen penelitian artinya peneliti itu sendiri. Lalu menyusun pedoman wawancara yang berisi pertanyaan, dan pedoman observasi serta beberapa dokumentasi yang berkaitan menggunakan objek penelitian. akibat penelitian memberikan bahwa proses pembelajaran ilmu pengetahuan sosial di MTsN 1 Kota Payakumbuh telah menerapkan pembelajaran dan evaluasi berdefensiasi menjadi perwujudan pola penerapan merdeka belajar serta implementasi dari pola penerapan merdeka belajar itu berdampak baik terhadap penanaman sikap sosial peserta didik, berakibat pembelajaran ilmu pengetahuan sosial lebih menyenangkan, berkualitas dan bermakna, karena menggunakan penerapan merdeka belajar peserta didik mempunyai kemampuan berfikir kritis, memiliki kepekaan emosi, berbakat serta memiliki daya khayalan yang tinggi, implikasi berasal penelitian ini dibutuhkan menjadi upaya mempertinggi kualitas pendidikan serta mengatasi masalah-masalah pendidikan spesifik di MTsN 1 Kota Payakumbuh. Meskipun penelitian ini merupakan bahan kajian yang baru dibahas serta bahkan masih terjadi pro-kontra dikalangan tokoh-tokoh pendidikan namun penulis berharap penelitian ini akan sebagai bahan rujukan buat penelitian selanjutnya serta memperkaya penelitian sebelumnya.</p>
INTELIGENCIA ARTIFICIAL COMO IMPULSOR DE CAPACIDAD DINÁMICA DE INNOVACIÓN CASO: CERVECERÍAS ARTESANALES DE MANABÍ, ECUADOR
Authors: Zambrano Yohanson Hidalgo , Marcillo Jipson Bravo , Martínez Benigno Alcívar , Moreira César Andrade 
Published: September 2024

Objetivo: El objetivo fue evaluar cómo la inteligencia artificial influye en la capacidad de estas cervecerías para innovar y adaptarse a entornos cambiantes.

Marco Teórico: Se estudió el impacto de la inteligencia artificial en la capacidad dinámica de innovación en las cervecerías artesanales de Manabí, partiendo de la premisa de mejorar significativamente el rendimiento y la competitividad en este sector.

Método: Se utilizó un enfoque mixto, adoptando una revisión bibliográfica con un estudio de campo, lo cual permitió analizar las variables inteligencia artificial y capacidad dinámica de innovación en las cervecerías. Los métodos descriptivo, deductivo e inductivo facilitaron el análisis de la información.

Resultados y Discusión: Los resultados mostraron una correlación positiva entre la implementación y el uso de la inteligencia artificial y diversas dimensiones de la capacidad de innovación, como la orientación al cliente y al mercado, así como el desempeño financiero e innovador. En concordancia, Ayala y Haro (2024), aseguran que la implementación efectiva de IA requiere cambios en procesos y estructuras organizacionales.

Implicaciones de la investigación: La implementación de la inteligencia artificial en las cervecerías artesanales de Manabí muestra un impacto moderado en la optimización del tiempo, la mejora de los servicios y la reducción de costos. Las capacidades dinámicas de innovación muestran una aceptación positiva del 60% en cuanto a la implementación de soluciones innovadoras y creativas donde Peñaloza y Martínez (2020), atribuyen que esta impulsa el crecimiento económico y la competitividad.

Originalidad/Valor: La aplicabilidad de la Inteligencia Artificial aporta significativamente a las capacidades dinámicas de innovación, a la orientación al cliente, al mercado y la tecnología.
Post-COVID-19 Kawasaki-Like Vasculitis and Endocarditis: A Case Report
Authors: Abdessamad Hilal , Saad Charbel , Abou Saad Tarek , Mortada Shaza , Ejbeh Sarkis , Zalloum Richard , Husni Rola , Mokhbat Jacques E. 
Published: September 2024

Background: Coronavirus Disease of 2019 (COVID-19) can cause mild to severe infection, but with a combination of inflammatory complications that target virtually anywhere in the body. Cardiac complications remain of utmost importance as they have the highest association with mortality.
Case presentation: A 32-year-old male presents with a fever of unknown origin for a period of 3 months post SARS-CoV-2 infection. He was found to have endocarditis and underwent an aortic valve replacement that was complicated by an aortic aneurysm, needing another surgery. The fever and aneurysm remitted after a new COVID-19 infection and the patient underwent a Bentall procedure with reimplantation of the coronary arteries.
Discussion: Cardiac complications of COVID-19 can range from small to large arteritis, valvopathy and aortic aneurysms, which can have significant morbidity and mortality, leading to the need of surgery and prolonged treatment. The scarcity of such cases makes reporting imperative so that clearer guidelines of management can be established.
Conclusion: Cardiovascular complications of COVID-19 remain the scariest and the least reported, which necessitates the presence of more evidence of their management, which can be lifesaving.
Diagnóstico Ambiental e Caracterização da Área de Preservação Permanente do Igarapé Encrenca em Rolim de Moura, Rondônia, Brasil
Authors: Da Silva Ribeiro Robson , Vanessa Silveira Oliveira Lilian , Henrique Rodrigues de Oliveira Barros Afonso , Da Silva Alves Ronepablo , Janones da Rocha Karen , Faião Alves Maltezo Ketlen , Michele de Quadros Tronco Kenia , Cristiane Alves Márcia , Vendruscolo Jhony , Cades Mariza , Mauro Santana da Silva José 
Published: September 2024

O igarapé Encrenca cruza a cidade de Rolim de Moura e tem sua nascente próximo ao centro urbano. O município teve uma ocupação despreocupada e sem planejamento com as questões ecológicas, ocasionando a ocupação inadequada em Áreas de Preservação Permanente, além de, desmatamento e má conservação dos leitos. Objetivou-se avaliar o igarapé em diferentes pontos ao longo do curso d’água, identificando e evidenciando os pontos de fragilidade e suas fontes de degradação. Sendo utilizado unidades amostrais -UA-dispostas a cada 500 m ao longo do igarapé, realizando coleta de água, solo e serapilheira, e levantamento de check-list. A partir dos dados obtidos das análises, foram geradas 63 variáveis, submetidas à análise de componentes principais (ACP), posteriormente sendo selecionada as 20 variáveis mais relevantes e realizada uma nova ACP. Os dados da ACP, permitiu o agrupamento do igarapé em 2 grupos: Grupo 1 com as UAs P1-1, P1-2, P1-3, P2-1, P2-3, P2-4 e P3-1, apresentando variáveis que indicam maior preservação, sendo os pontos localizados mais próximos as nascentes; e Grupo 2 com as UAs P2-2, P2-5, P3-2, P3-3, P3-4, P4-1, P4-2, P5-1, P5-2, P6, P7, P8 e P9, com presença de variáveis que indicam as áreas com maior degradação, localizadas próximas à foz. O igarapé da Encrenca expressa aumento do seu nível de degradação, conforme ele se distancia de suas nascentes e se aproxima de sua foz que se encontra próximo ao centro urbano de Rolim de Moura.
Determining the trajectory of a smoke flame using satellite images
Authors: Gribkov A. M. , Chichirova N. D. , Mirsalikhov K. M. 
Published: September 2024

In a number of cases, for example, when choosing the design of the exit part of a chimney, when taking into account the characteristics of the underlying surface and meteorological characteristics of the area, or as a means of verifying variant calculations in the ANSYS environment, a study of the trajectory of the smoke plume in natural conditions is required. One of the simplest, most convenient and cheapest ways to determine a trajectory is to photograph it and then decipher it. So, for example, a vertical chimney, if the direction of the camera is raised above the horizon, and the chimney is not located in the center of the photo, it looks inclined in the photo. This means that at the top of the image and at the bottom there are different horizontal linear scales of the image. The angle at which the camera was installed can also be calculated from the photograph. In addition, the same vertical height interval occupies a smaller length in the upper part of the pipe and a larger one in the lower part. This means that in the upper part of the image and in the lower part there are different vertical linear scales of the image. It is also necessary to take into account the fact that objects of the same size have different sizes in the picture. The further away an object is located, the less space it takes up in the photo. Thus, in order to calculate the trajectory of a smoke plume from a photograph, we need to know the orientation of the main optical axis during the photograph and the distance to the photograph plane, which we choose perpendicular to the main optical axis and passing through the object, from which we can determine the initial average linear scales, and the direction smoke plume spread.TARGET. Development of a new, simpler method for recalculating the trajectory of a smoke plume from a chimney using available Google maps to calculate the original scales in a photograph.METHODOLOGY Allows you to trace the entire sequence of actions from determining the coordinates of the shooting point to recalculating the coordinates of the selected points of the torch boundaries in the photograph relative to the emission source onto an orthogonal plane.RESULTS. A new method for calculating the trajectory of a smoke plume from a single photograph has been developed, the accuracy of which was tested using known sizes in the original objects, and which turned out to be higher than that previously used for these purposes.