bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building capacity for testing sterile insect technique against Aedes-borne diseases in the Pacific: a training workshop and launch of sterile insect technique trials against Aedes aegypti and arboviral diseases
Authors: Foley Nicole , Fouque Florence , Zhong Qingxia , Bossin Herve , Bouyer Jeremy , Velayudhan Raman , Nett Randall , Drexler Anna 
Published: October 2024

Abstract
Background
Vector-borne diseases cause morbidity and mortality globally. However, some areas are more impacted than others, especially with climate change. Controlling vectors remains the primary means to prevent these diseases, but new, more effective tools are needed. The World Health Organization (WHO) prioritized evaluating novel control methods, such as sterile insect technique (SIT) for control of Aedes-borne diseases. In response, a multiagency partnership between the U.S. Centers for Disease Control and Prevention (CDC), the Special Programme for Research and Training in Tropical Diseases (TDR), WHO, and the International Atomic Energy Agency (IAEA) supported the operational implementation and evaluation of SIT against Aedes aegypti and arboviral diseases in the Pacific through a consortium of regional partners (PAC-SIT Consortium).

Main text
A workshop was held from 2 to 6 May 2023, during which PAC-SIT country participants, researchers, and stakeholders in SIT, scientific advisory committee members, and organizational partners came together to review the principles and components of SIT, share experiences, visit field sites and the SIT facility, and officially launch the PAC-SIT project. Working in groups focused on entomology, epidemiology, and community engagement, participants addressed challenges, priorities, and needs for SIT implementation.

Conclusions
The PAC-SIT workshop brought together researchers and stakeholders engaged in evaluating SIT for arboviral diseases in the Pacific region and globally. This training workshop highlighted that many countries are actively engaged in building operational capacities and phased testing of SIT. The workshop identified a key need for robust larger-scale studies tied with epidemiological endpoints to provide evidence for the scalability and impact on mosquito-borne diseases.
Volume changes in the contralateral submandibular gland following unilateral gland excision in oral cancer patients
Authors: Kang Yei-Jin , Park Young-Wook , Choi Hang-Moon , Kim Seong-Gon 
Published: October 2024

Abstract
Background
The effects of unilateral submandibular gland excision on the size of the contralateral gland are not well understood, with no human studies reported to date. This study aims to investigate the impact of unilateral submandibular gland excision on the contralateral gland’s size, providing insights into compensatory mechanisms and their clinical implications.

Method
This retrospective study involved patients with oral cancer who underwent unilateral submandibular gland excision and ipsilateral neck dissection at Gangneung-Wonju National University Dental Hospital between 2008 and 2023. Patients were included if they had preoperative and follow-up 3D radiological images. The contralateral submandibular gland volume was measured using 3D Slicer software on preoperative, post-operative, and follow-up radiographic data.

Results
The mean volume change of the contralateral submandibular gland was 1.35 ± 2.06 cm3, with a mean change ratio of 1.18 ± 0.24. These changes were statistically significant (p = 0.006). Other factors such as age, gender, and radiotherapy did not significantly affect the volume change ratio (p > 0.05).

Conclusion
The contralateral submandibular gland exhibits a statistically significant increase in volume following unilateral gland excision, indicating compensatory hypertrophy. This morphological adaptation should be considered in post-operative care and surgical planning for oral cancer patients to optimize outcomes.
Rheumatic fever and long-term use of benzathine penicillin as possible risk factors for extensive macular atrophy with pseudodrusen in a Brazilian cohort
Authors: Moreira-Neto Carlos Augusto , Schmidt Andujar Rafaella Atherino , Chao John Chii Tyng , Vasconcelos Huber , Alves Fábio Eduardo Eberhardt , Rodrigues Gabriela Doná , Hirt Bruno , Arana Jayme , Souza Eduardo Cunha , Maia André , Sallum Juliana Maria Ferraz , Moreira Carlos Augusto 
Published: October 2024

Abstract
Background
Although there has been a large increase in the number of extensive macular atrophy with pseudodrusen (EMAP) cases, the basic aspects of this disease remain unknown. Brazilian patients have a common past history of rheumatic fever (RF) and/or benzathine penicillin (BP) treatment possibly related to the disease. We analyzed how RF and BP might be correlated with EMAP in Brazilian patients.

Design
Observational, retrospective, case-control study.

Methods
The databases of three private eye clinics in Brazil were searched for patients with an EMAP-like appearance. Each patient was asked about a previous history of RF and/or long-term use of BP. Patients underwent best-corrected visual acuity (BCVA) measurement, color fundus imaging, fundus autofluorescence (FAF) imaging, optical coherence tomography (OCT) imaging, and electroretinography (ERG). The following characteristics were analyzed: subretinal drusenoid deposits (SDD), pigment mottling, retinal pigment epithelial/basement membrane (RPE/BM) separation, outer retinal or RPE atrophy, and identification of a paving stone-like appearance. The choroidal thickness was measured using enhanced depth imaging OCT. The central atrophic area was measured manually on ultra-wide-field FAF.

Results
A total of 154 eyes of 77 patients (women, 66.2%; mean age, 58.6 years) with EMAP were included; 90.9% of patients were diagnosed with RF; 94.8% had been treated with BP and treatment was started at an average age of 7.3 years (mean duration, 11.8 years). The treatment duration was significant for the area of atrophy (P = 0.027) in which each 1-year increase in treatment duration led to an average reduction of 6.91 mm2 in area. The age at diagnosis of RF was significant (P = 0.026) for SDD. The increase of 1 year in the diagnosis of RF (late disease) led to a reduction of 24% in the chance of central SDD being present. On OCT, 65.5% eyes had SDD and more than 70% had a split RPE/BM and outer retinal or RPE atrophy. The choroidal thickness in patients with EMAP was significantly (P < 0.001) thinner than the control group. The ERG was abnormal in all eyes.

Conclusion
These findings may suggest a relation between RF and EMAP in Brazilian patients. Patients with EMAP should be questioned about a history of RF.
Comparison of heart failure risk assessment tools among cancer survivors
Authors: Soh Cheng Hwee , Marwick Thomas H. 
Published: October 2024

Abstract
Background
Cancer survivors have an increased risk of incident heart failure (HF) attributable to shared risk factors and cancer treatment-induced cardiac dysfunction. Selection for HF screening depends on risk assessment, but the optimal means of assessing risk is undefined. We undertook a comparison of HF risk calculators among survivors.

Methods
In this study from the UK Biobank, cancer and HF diagnoses were determined based on the International Classification of Diseases (ICD)-10 code and non-cancer participants were included as controls. Participants’ risk of incident HF was determined using the Heart Failure Association-International Cardio-oncology Society (HFA-ICOS), the Atherosclerosis Risk in Communities (ARIC-HF) and the Pooled Cohort Equations to Prevent Heart Failure (PCP-HF). The predictive performances of each were compared using the area under the curve (AUC).

Results
After propensity matching with age and sex, 9,232 survivors from breast cancer or lymphoma (mean age 59.9 years, 87.8% female), and 23,800 survivors from other cancer types (mean age 59.1 years, 85.8% female) were included in the analysis. The discriminative value for HFA-ICOS (AUC 0.753 [95%CI: 0.739–0.766]) and ARIC-HF (0.757 [95%CI: 0.744–0.770]) were similar, and superior to PCP-HF (0.717 [95%CI: 0.702–0.732]). The overall performance for each risk score was better among participants in other cancer types than those with breast cancer and lymphoma.

Conclusions
HFA-ICOS and ARIC-HF outperformed the PCP-HF among cancer- and non-cancer cohort, although all showed modest discrimination for incident HF to be applied to clinical practice. A cancer-specific HF prediction tool could facilitate HF prevention among survivors.
Genital findings in adult females: a forensic analysis of photographic records
Authors: Al-Saif Dalia , Al-Farayedhi Maram , Al-Shamsi Ghada , Al-Zahrani Azzah , Al-Bayat Marwah 
Published: October 2024

Abstract
Background
In the investigation of sexual assault cases, a standard practice involves examining female genitalia to identify injuries. The majority of research was done to examine findings in the child age group, but very little research was done on the adult age group. There is a need for guidelines to follow for the interpretation of adult female findings as they hold the same significance as in children. The Dammam Forensic Medicine Center conducted a retrospective chart review study in the period from 2014 to 2021 to examine adult female genital findings utilizing photographic documentation.

Results
One hundred sixty-three cases involving adults between the ages of 18 and 52 were examined. Cases were divided into two groups to focus on hymenal findings that fell in the class of no expert consensus. The first group included self-defined virgins, who denied having ever experienced vaginal penetration in their entire lives, including the reported incidence, which represented 38 cases. The rest of the cases had at least a single incident of vaginal penetration. The normal genitourinary findings were found comparable to those in the child age group. All of the participants who showed notches or clefts, below the 3 o’clock or 9 o’clock location, which extends nearly to the base of the hymen, but is not a complete transection belonged to the group with a history of vaginal penetration. The three participants who showed a notch or a cleft in the hymen rim at 3 o’clock or 9 o’clock which extends nearly to the base of the hymen, but is not a complete transection belonged to the same group.

Conclusions
Findings that lack expert consensus in the child age group are likely the result of injury in the study participants. This result gives valuable information on genital findings in self-identified virgin adult females, which can be utilized in conjunction with other studies to establish standards for the assessment of cases of alleged sexual assault in adult females.
Radioprotective potential of pomegranate peel extract against gamma irradiation-induced hazards
Authors: Hamieda Shimaa Farag , Saied Mona , Abd-El-Nour K. N. , Hassan Amal I. 
Published: October 2024

Abstract
Background
While gamma irradiation’s damaging biological effects are well-established, the natural radioprotective agents from agricultural waste remain an underexplored area of significant potential.

Aim of study
This study was to investigate the novel use of pomegranate peel ethanol extract (PE) as a radioprotective agent against gamma radiation damage.

Methods
We pretreated Wistar rats with PE (100 mg/kg) for 14 days prior to 6 Gy gamma irradiation. We analyzed blood biochemicals, oxidative stress, and inflammatory markers. These included tests of red cell membrane integrity, lipid and protein oxidation, antioxidant enzyme levels, and cytokine profiles.

Results
The study showed that PE demonstrated remarkable radioprotective effects across multiple parameters. Antioxidants were significantly enhanced, as evidenced by increased glutathione peroxidase activity (87.00 ± 6.11 mg/ml in PE-treated irradiated rats compared to 26.40 ± 1.21 mg/ml in irradiated controls). Oxidative damage was markedly reduced, with MDA levels dropping from 9.59 ± 0.24 nmol/ml in irradiated controls to near-control levels in PE-treated rats. Notably, PE treatment resulted in unprecedented maintenance of red blood cell membrane integrity post-irradiation. Furthermore, PE exhibited novel modulation of inflammatory cytokines, effectively reducing pro-inflammatory markers IL-6 and TNF-α while simultaneously boosting anti-inflammatory IL-4 and IL-10 levels. These multifaceted protective effects highlight PE’s potential as a comprehensive radioprotective agent.

Conclusion
This study presents PE as an effective new natural radioprotective agent. Its protective effect is due to its high polyphenol content, which enhances antioxidant defenses, reduces oxidative damage, and prevents inflammation. The findings open new avenues for sustainable, cost-effective radioprotection strategies and demonstrate the potential for repurposing agricultural byproducts for critical health applications.
MVD-HG: multigranularity smart contract vulnerability detection method based on heterogeneous graphs
Authors: Xu Jingjie , Wang Ting , Lv Mingqi , Chen Tieming , Zhu Tiantian , Ji Baiyang 
Published: October 2024

AbstractSmart contracts have significant losses due to various types of vulnerabilities. However, traditional vulnerability detection methods rely extensively on expert rules, resulting in low detection accuracy and poor adaptability to novel attacks. To address these problems, in this paper, deep learning methods are combined with smart contract vulnerability code detection approaches. Abstract syntax trees (ASTs), which are special isomorphic graph structures, are an important bridge between source code and graph neural networks. By learning the AST, the model can understand the semantics of the source code. Moreover, graph neural networks have an increasing ability to address complex heterogeneous graphs. Therefore, control flow graphs are fused with data flow graphs on the basis of the ASTs to build heterogeneous graphs with richer code semantics. Furthermore, multigranularity analysis of the vulnerability detection results is performed, including coarse-grained contract-level vulnerability detection and fine-grained line-level vulnerability detection. Through this multigranularity detection approach, vulnerabilities in contracts can be identified and analysed more comprehensively, providing a richer perspective and more solutions for vulnerability detection. The experimental results show that the proposed multigranularity vulnerability detection method based on heterogeneous graphs (MVD-HG) improves both the accuracy and range of the detected vulnerability types in contract-level vulnerability detection tasks; moreover, in the line-level vulnerability detection task, the MVD-HG model achieves significant results and addresses the shortcomings of existing methods. In addition, based on code generation methods used in related fields, a data enhancement method based on the source code is developed, which effectively expands the experimental dataset to address the reduced credibility of the results due to insufficient amounts of data.
Influence of proximal femoral morphology on osteointegration of the AMIS uncemented femoral stem in modern hip arthroplasty
Authors: Maton Maxime , Vandromme Emile , Charles Tatiana , Kapanci Bilal , Jayankura Marc 
Published: October 2024

Abstract
Background
Indications for total hip arthroplasty (THA) have evolved over recent decades, with a growing trend toward operating on younger and more active patients. With this shift in patient demographics, there has been a change in femoral stem designs and proximal femoral morphology encountered. This study aimed to evaluate the potential correlation between femoral stem osteointegration and proximal femoral morphology using the Dorr and Noble classifications.

Materials and methods
We conducted a retrospective review of 122 uncemented femoral stems (AMIstem Medacta, triple tapered). The demographic data analyzed included sex, age, stem size, and surgical indications. Preoperative radiographs were reviewed to determine the Dorr classification as well as the canal-to-calcar isthmus ratio, cortical index, and canal flare index. Postoperative radiographs were carefully reviewed to identify the presence of potential postoperative radiolucencies. Inter- and intra-observer agreements for these parameters were also analyzed.

Results
Significant radiolucencies (> 2 mm) were found in 19.5% of the patients. Of all the variables analyzed, the cortical index was the only parameter significantly associated with the appearance of clinically significant radiolucency, with a threshold value of 0.62.

Conclusions
The appearance of radiolucencies is multi-factorial. Nevertheless, in this study, a high cortical index (> 0.62), representing the champagne flute morphology, was found to be associated with the development of significant radiolucencies.
Monoclonal antibodies: From magic bullet to precision weapon
Authors: Aboul-Ella Hassan , Gohar Asmaa , Ali Aya Ahmed , Ismail Lina M. , Mahmoud Adham Ezz El-Regal , Elkhatib Walid F. , Aboul-Ella Heba 
Published: October 2024

AbstractMonoclonal antibodies (mAbs) are used to prevent, detect, and treat a broad spectrum of non-communicable and communicable diseases. Over the past few years, the market for mAbs has grown exponentially with an expected compound annual growth rate (CAGR) of 11.07% from 2024 (237.64 billion USD estimated at the end of 2023) to 2033 (679.03 billion USD expected by the end of 2033). Ever since the advent of hybridoma technology introduced in 1975, antibody-based therapeutics were realized using murine antibodies which further progressed into humanized and fully human antibodies, reducing the risk of immunogenicity. Some benefits of using mAbs over conventional drugs include a drastic reduction in the chances of adverse reactions, interactions between drugs, and targeting specific proteins. While antibodies are very efficient, their higher production costs impede the process of commercialization. However, their cost factor has been improved by developing biosimilar antibodies as affordable versions of therapeutic antibodies. Along with the recent advancements and innovations in antibody engineering have helped and will furtherly help to design bio-better antibodies with improved efficacy than the conventional ones. These novel mAb-based therapeutics are set to revolutionize existing drug therapies targeting a wide spectrum of diseases, thereby meeting several unmet medical needs. This review provides comprehensive insights into the current fundamental landscape of mAbs development and applications and the key factors influencing the future projections, advancement, and incorporation of such promising immunotherapeutic candidates as a confrontation approach against a wide list of diseases, with a rationalistic mentioning of any limitations facing this field.
Barriers to accessing perinatal mental health services and suggestions for improvement: qualitative study of women of Black and south Asian backgrounds
Authors: Jovanović Nikolina , Packer Katy C. , Conneely Mebh , Bicknell Sarah , Copello Alex , McCabe Rose , Dirik Ayşegül , Janković Jelena 
Published: October 2024

Background
Maternity outcomes for women from certain ethnic groups are notably poor, partly owing to their not receiving treatment from services.

Aims
To explore barriers to access among Black and south Asian women with perinatal mental health problems who did not access perinatal mental health services and suggestions for improvements, and to map findings on to the perinatal care pathway.

Method
Semi-structured interviews were conducted in 2020 and 2021 in the UK. Data were analysed using the framework method.

Results
Twenty-three women were interviewed, and various barriers were identified, including limited awareness of services, fear of child removal, stigma and unresponsiveness of perinatal mental health services. Whereas most barriers were related to access, fear of child removal, remote appointments and mask-wearing during COVID-19 affected the whole pathway. Recommendations include service promotion, screening and enhanced cultural understanding.

Conclusions
Women in this study, an underrepresented population in published literature, face societal, cultural, organisational and individual barriers that affect different aspects of the perinatal pathway.
Clinical Outcomes in Patients with Phosphate Abnormalities After Cardiac Surgery: A Retrospective Cohort Study
Authors: Steck Dominik T. , Mostofi Nicki , Togashi Kei , Li Rui , Wu David , Wells Lauren , Fong Christine T. , Tillinghast Kyle , O’Reilly-Shah Vikas N. , Jelacic Srdjan 
Published: October 2024

BACKGROUND:
The clinical significance and incidence of phosphate abnormalities in cardiac surgery have not been investigated extensively. We hypothesize that phosphate abnormalities are associated with a longer time to tracheal extubation.

METHODS:
This was a single-center, retrospective cohort study in patients who underwent nontransplant cardiac surgery with cardiopulmonary bypass between August 2009 and December 2020. Serum phosphate levels were measured within 6 hours of arrival to the intensive care unit (ICU). Select clinical outcomes were extracted from an intramural database: time to tracheal extubation, hospital length of stay, and in-hospital mortality. The lactate level within 6 hours of arrival to the ICU was extracted as well.

RESULTS:
A total of 2659 patients were included. There were 502 (18.9%) patients who were found to be hypophosphatemic (phosphate <2.5 mg/dL), 1905 (71.6%) had normal phosphate levels (phosphate 2.5–4.5 mg/dL), and 252 (9.5%) were hyperphosphatemic (phosphate >4.5 mg/dL). Hyperphosphatemia was associated with 26% longer time to tracheal extubation (incident rate ratio, 1.26, 95% confidence interval [CI], 10%, 44%, P = .001), 37% longer hospital length of stay (acceleration factor = 0.63, 95% CI, −43% to −30%); P < .001), and increased in-hospital mortality (odds ratio, 4.0; 95% CI, 2.3–7.1; P < .001) when compared to patients with normal phosphate levels. These associations were not found for hypophosphatemia.

CONCLUSIONS:
Hyperphosphatemia in the immediate postoperative period after cardiac surgery is associated with adverse clinical outcomes. Future studies will need to investigate if actively correcting the phosphate level has an impact on clinical outcomes.