bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key role of surface concentration on reproducibility and optimization of SERS sensitivity
Authors: Santos Jonnatan J. , Toma Sergio H. , Corio Paola , Araki Koiti 
Published: July 2017

A systematic study was carried out demonstrating that surface concentration is the key factor that must be controlled to overcome the reproducibility problems that has long been haunting surface enhanced Raman spectroscopy (SERS), converting it in a quantitative analytic tool without using any internal standard. The 1,10‐phenanthroline molecule (phen) used as model compound can assume different orientations on the surface as a function of surface concentration, but a linear response as a function of concentration was realized in a well‐defined range of gold nanoparticles (AuNPs) and phen concentration ratios, allowing to fully explore the very high sensitivity of SERS technique. A detection at a low concentration (5.0 × 10−8 mol dm−3) was achieved controlling the surface concentration in the optimum range where the signals of the species of analytic interest are maximized whilst the signals of all other species are minimized. Copyright © 2017 John Wiley & Sons, Ltd.
Microstructure and tensile properties of various varieties of rice husk
Authors: Chen Ziyong , Xu Yangzi , Shivkumar Satya 
Published: July 2017

AbstractBACKGROUNDRice husk is a complex hierarchical assembly of hollow fibers consisting of cellulose, hemicellulose and lignin. In addition, it can also contain pectin and significant amounts of silica. Rice husk can be used in diverse applications and generally in the form of rice husk powder. This study aimed to investigate the structural features and mechanical properties of various varieties of whole rice husks.RESULTSRice husk consists of three sections: epidermis, sub‐hypodermis and hypodermis. The thickness of these layers, the diameters of the hollow fibers and the wall thickness vary with the variety of rice husk. The elastic modulus is typically between 0.3 and 2.6 GPa, and the ultimate tensile strength varies from 19 to 135 MPa depending on the variety of rice husk.CONCLUSIONRice husk has a unique hierarchical structure in which the fibers exhibit a staggered perpendicular arrangement and the entire fiber sections are covered by an external shell. The tensile properties vary with the variety of rice husk. The wide range in these tensile properties may be attributed to the size and orientation of the fibers. © 2017 Society of Chemical Industry
Chemical profile of pineapple cv. Vitória in different maturation stages using electrospray ionization mass spectrometry
Authors: Ogawa Elizângela M , Costa Helber B , Ventura José A , Caetano Luiz CS , Pinto Fernanda E , Oliveira Bruno G , Barroso Maria Eduarda S , Scherer Rodrigo , Endringer Denise C , Romão Wanderson 
Published: July 2017

AbstractBACKGROUNDPineapple is the fruit of Ananas comosus var. comosus plant, being cultivated in tropical areas and has high energy content and nutritional value. Herein, 30 samples of pineapple cv. Vitória were analyzed as a function of the maturation stage (0–5) and their physico‐chemical parameters monitored. In addition, negative‐ion mode electrospray ionization mass spectrometry [ESI(−)FT‐ICR MS] was used to identify and semi‐quantify primary and secondary metabolites present in the crude and phenolic extracts of pineapple, respectively.RESULTSPhysico‐chemical tests show an increase in the total soluble solids (TSS) values and in the TSS/total titratable acidity ratio as a function of the maturity stage, where a maximum value was observed in stage 3 (¾ of the fruit is yellow, which corresponds to the color of the fruit peel). ESI(−)FT‐ICR MS analysis for crude extracts showed the presence mainly of sugars as primary metabolites present in deprotonated molecule form ([M − H]− and [2 M − H]− ions) whereas, for phenolic fractions, 11 compounds were detected, being the most abundant in the third stage of maturation. This behavior was confirmed by quantitative analysis of total polyphenols.CONCLUSIONESI‐FT‐ICR MS was efficient in identifying primary (carbohydrates and organic acids) and secondary metabolites (13 phenolic compounds) presents in the crude and phenolic extract of the samples, respectively. © 2017 Society of Chemical Industry
Chemoenzymatic Synthesis of Polypeptides for Use as Functional and Structural Materials
Authors: Tsuchiya Kousuke , Numata Keiji 
Published: July 2017

AbstractPolypeptides inspired by the natural functional and structural proteins present in living systems are promising materials for various fields in terms of their versatile functionality and physical properties. Designing and synthesizing mimetic sequences of specific peptide motifs in proteins are important for exploring the functionality of natural proteins. Chemoenzymatic polymerization, which utilizes aminolysis (i.e., the reverse reaction of hydrolysis catalyzed by proteases), is a useful technique for synthesizing artificial polypeptide materials and has several advantages, including facile synthesis protocols, environmental friendliness, scalability, and atom economy. In this review, recent progress in chemoenzymatic polypeptide synthesis for the production of functional and structural materials for various applications is summarized in conjunction with the current status of technical challenges in the field.
Susceptibility‐induced distortion correction in hyperpolarized echo planar imaging
Authors: Miller Jack J. , Lau Angus Z. , Tyler Damian J. 
Published: July 2017

PurposeEcho planar imaging is an attractive rapid imaging readout that can image hyperpolarized compounds in vivo. By alternating the sign of the phase encoding gradient waveform, spatial offsets arising from uncertain frequency shifts can be determined. We show here that blip‐reversed echo planar imaging can also be used to correct for susceptibility and B0 inhomogeneity effects that would otherwise produce image‐domain distortion in the heart.MethodsPreviously acquired blip‐reversed cardiac 3D‐Spectral‐Spatial echo planar imaging volumetric timecourses of hyperpolarized [1‐13C]pyruvate were distortion corrected by a deformation field estimated by reconstructing signal‐to‐noise ratio (SNR)‐weighted progressively subsampled temporally summed images of each metabolite.ResultsReconstructing blip‐reversed data as proposed produced volumetric timecourses that overlaid with proton reference images more consistently than without such corrections.ConclusionThe method proposed may form an attractive method to correct for image‐domain distortions in hyperpolarized echo planar imaging experiments. Magn Reson Med 79:2135–2141, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Cavity expansion in strain hardening frictional soils under drained condition
Authors: Chen S.L. , Abousleiman Y.N. 
Published: July 2017

SummaryA rigorous semianalytical solution for the drained expansion of a cylindrical cavity in frictional soils is presented. Following the restrict material (Lagrangian) description approach recently developed by the authors, the cavity analysis has been extended to the 3‐invariant plasticity soil model, which is governed by the Matsuoka‐Nakai yield criterion combined with the friction angle hardening depending on the development of deviatoric plastic strain. The 4 desired first‐order ordinary differential equations are subsequently derived, which enable the 3 stress components, volumetric strain, and plastic shear strain in the plastic zone to be readily calculated through the standard numerical procedure. Numerical examples illustrate how the major constitutive parameter, in situ stress state, and the third stress invariant impact the overall response of the cavity as well as its ultimate pressure. Specific consideration is given to the influence of the plastic hardening parameter on the stress path of a soil element at the cavity wall.
Nasogastric tube as abdominal pressure sensor in urodynamics—Proof of concept of a novel approach
Authors: VijayGanapathy Sundaramoorthy , Karthikeyan Vilvapathy Senguttuvan , Mallya Ashwin , Poonawala Ali , Keshavamurthy Ramaiah 
Published: July 2017

AimsThe standard sensor for abdominal pressure (Pabd) measurement in urodynamics (UD) is a rectal sensor. In patients where the rectum is not available due to prior surgery or when external anal sphincter (EAS) tone is poor, rectal sensor may slip, making Pabd recording unreliable. Vaginal Pabd measurement and wireless vaginal sensors have been tried. We present our preliminary series of a novel nasogastric tube (NG) sensor for Pabd measurement.MethodsWe identified patients undergoing UD with a NG Pabd sensor from a prospectively maintained UD database of a tertiary care urological center between July 2013 and December 2016.ResultsOut of 1325 urodynamic procedures done, 46 (3.5%) were performed using NG Pabd sensor. The median (IQR) age was 44 (12) years. Indications for UD in these patients were neurogenic bladder in 22 (47.8%), urinary retention in 17 (37%), post‐meningomyelocele repair in four (8.7%), traumatic paraplegia in two (4.3%), and cervical myelopathy in one (2.2%). The indications for NG Pabd sensor were lax EAS tone (40; 86.9%), post‐abdominoperineal resection (2; 4.3%), and painful thrombosed hemorrhoids (4; 8.7%). It was possible to make definitive urodynamic diagnosis in all patients using NG Pabd sensor. Initial calibration and NG Pabd excursions throughout the study were similar to that of rectal Pabd sensor. There were no problems with NG tube tolerance.ConclusionUse of nasogastric sensor is feasible, accurate, cost‐effective, and viable alternative for Pabd measurement in patients with poor anal tone or absent rectum due to postoperative status.
An efficient preconditioner for the fast simulation of a 2D stokes flow in porous media
Authors: Quaife Bryan , Coulier Pieter , Darve Eric 
Published: July 2017

SummaryWe consider an efficient preconditioner for a boundary integral equation (BIE) formulation of the two‐dimensional Stokes equations in porous media. While BIEs are well‐suited for resolving the complex porous geometry, they lead to a dense linear system of equations that is computationally expensive to solve for large problems. This expense is further amplified when a significant number of iterations is required in an iterative Krylov solver such as generalized minimial residual method (GMRES). In this paper, we apply a fast inexact direct solver, the inverse fast multipole method, as an efficient preconditioner for GMRES. This solver is based on the framework of
‐matrices and uses low‐rank compressions to approximate certain matrix blocks. It has a tunable accuracy ε and a computational cost that scales as
. We discuss various numerical benchmarks that validate the accuracy and confirm the efficiency of the proposed method. We demonstrate with several types of boundary conditions that the preconditioner is capable of significantly accelerating the convergence of GMRES when compared to a simple block‐diagonal preconditioner, especially for pipe flow problems involving many pores.
Cost and Health Care Utilization Implications of Bariatric Surgery Versus Intensive Lifestyle and Medical Intervention for Type 2 Diabetes
Authors: Banerjee Souvik , Garrison Louis P. , Flum David R. , Arterburn David E. 
Published: July 2017

ObjectiveThe aim of this study was to compare the cost and health care utilization of patients with obesity and type 2 diabetes mellitus (T2DM) randomized into either Roux‐en‐Y gastric bypass (RYGB) surgery or an intensive lifestyle and medical intervention (ILMI).MethodsThis analysis (N = 745) is based on 2‐year follow‐up of a small randomized controlled trial (RCT); adult patients with obesity and T2DM were recruited between 2011 and 2012 from Kaiser Permanente Washington. Comparisons were made for patients randomized into either RYGB (N = 15) or ILMI (N = 17).ResultsThere were no significant cost savings for RYGB versus ILMI patients through the follow‐up years. Pharmacy cost was lower for RYGB versus ILMI patients by about $900 in year 2 versus year 0; however, inpatient and emergency room costs were higher for surgery patients in follow‐up years relative to year 0. Median total cost for nonrandomized patients was higher in year 0 and in year 2 compared to randomized patients.ConclusionsBariatric surgery is not cost saving in the short term. Moreover, the costs of patients who enter into RCTs of RYGB may differ from the costs of those who do not enter RCTs, suggesting use of caution when using such data to draw inferences about the general population with obesity.
Pancreatic undifferentiated carcinoma with osteoclast‐like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma
Authors: Luchini Claudio , Pea Antonio , Lionheart Gemma , Mafficini Andrea , Nottegar Alessia , Veronese Nicola , Chianchiano Peter , Brosens Lodewijk AA , Noë Michaël , Offerhaus G Johan A , Yonescu Raluca , Ning Yi , Malleo Giuseppe , Riva Giulio , Piccoli Paola , Cataldo Ivana , Capelli Paola , Zamboni Giuseppe , Scarpa Aldo , Wood Laura D 
Published: July 2017

AbstractUndifferentiated carcinoma of the pancreas with osteoclast‐like giant cells (UCOGC) is currently considered a morphologically and clinically distinct variant of pancreatic ductal adenocarcinoma (PDAC). In this study, we report clinical and pathological features of a series of 22 UCOGCs, including the whole exome sequencing of eight UCOGCs. We observed that 60% of the UCOGCs contained a well‐defined epithelial component and that patients with pure UCOGC had a significantly better prognosis than did those with an UCOGC with an associated epithelial neoplasm. The genetic alterations in UCOGC are strikingly similar to those known to drive conventional PDAC, including activating mutations in the oncogene KRAS and inactivating mutations in the tumor suppressor genes CDKN2A, TP53, and SMAD4. These results further support the classification of UCOGC as a PDAC variant and suggest that somatic mutations are not the determinants of the unique phenotype of UCOGC. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Genomic signatures of pancreatic adenosquamous carcinoma (PASC)
Authors: Fang Yuan , Su Zhe , Xie Jing , Xue Ruidong , Ma Qi , Li Yanmeng , Zhao Yifan , Song Zeshi , Lu Xiongxiong , Li Hongwei , Peng Chenghong , Bai Fan , Shen Baiyong 
Published: July 2017

AbstractIn pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents ∼4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC harboured comparable genomic alterations, suggesting that the two cellular components develop from the same progenitor cancer cells. Our study has updated genomic knowledge to help with understanding mixed cancers of the pancreas. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma
Authors: Li Pei Chuan , Siddiqi Imran N , Mottok Anja , Loo Eric Y , Wu Chieh Hsi , Cozen Wendy , Steidl Christian , Shih Jean Chen 
Published: July 2017

AbstractMonoamine oxidase A (MAOA) is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines and produces H2O2. It facilitates the progression of gliomas and prostate cancer, but its expression and functional relevance have not been studied in lymphoma. Here, we evaluated MAOA in 427 cases of Hodgkin and non‐Hodgkin lymphoma and in a spectrum of reactive lymphoid tissues by immunohistochemistry on formalin‐fixed, paraffin‐embedded specimens. MAOA was expressed by Hodgkin Reed–Sternberg (HRS) cells in the majority of classical Hodgkin lymphomas (cHLs) (181/241; 75%), with 34.8% showing strong expression. Weak MAOA was also noted in a minority of primary mediastinal large B‐cell lymphomas (8/47; 17%) and in a mediastinal gray‐zone lymphoma. In contrast, no MAOA was found in non‐neoplastic lymphoid tissues, nodular lymphocyte‐predominant Hodgkin lymphoma (NLPHL; 0/8) or any other non‐Hodgkin lymphomas studied (0/123). MAOA was more common in Epstein–Barr virus (EBV)‐negative compared to EBV‐positive cHL (p < 0.0001) and was especially prevalent in the EBV‐negative nodular sclerosing subtype. Similar to primary human lymphoma specimens, most cHL‐derived cell lines displayed MAOA activity, whereas non‐Hodgkin‐lymphoma‐derived cell lines did not. The MAOA inhibitor clorgyline reduced the growth of L1236 cells and U‐HO1 cells, and shRNA knockdown of MAOA reduced the growth of L1236 cells. Conversely, ectopic overexpression of MAOA increased the growth of MAOA‐negative HDLM2 cells. Combined treatment with clorgyline and ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) was more effective in reducing cell growth than either regimen alone. In summary, MAOA is highly expressed in cHL and may reflect the distinct biology of this lymphoma. Further studies on the potential utility of MAOA as a diagnostic marker and therapeutic target are warranted. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Loss of the tumour suppressor gene AIP mediates the browning of human brown fat tumours
Authors: Magnusson Linda , Hansen Nils , Saba Karim H , Nilsson Jenny , Fioretos Thoas , Rissler Pehr , Nord Karolin H 
Published: July 2017

AbstractHuman brown fat tumours (hibernomas) show concomitant loss of the tumour suppressor genes MEN1 and AIP. We hypothesized that the brown fat phenotype is attributable to these mutations. Accordingly, in this study, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumours, loss of MEN1 was found both in white (one of 51 lipomas) and in brown fat tumours. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white‐to‐brown phenotype switch in brown fat tumours is mediated by the loss of AIP. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Using prescription monitoring program data to characterize out‐of‐pocket payments for opioid prescriptions in a state Medicaid program
Authors: Hartung Daniel M. , Ahmed Sharia M. , Middleton Luke , Van Otterloo Joshua , Zhang Kun , Keast Shellie , Kim Hyunjee , Johnston Kirbee , Deyo Richard A. 
Published: July 2017

AbstractBackgroundOut‐of‐pocket payment for prescription opioids is believed to be an indicator of abuse or diversion, but few studies describe its epidemiology. Prescription drug monitoring programs (PDMPs) collect controlled substance prescription fill data regardless of payment source and thus can be used to study this phenomenon.ObjectiveTo estimate the frequency and characteristics of prescription fills for opioids that are likely paid out‐of‐pocket by individuals in the Oregon Medicaid program.Research DesignCross‐sectional analysis using Oregon Medicaid administrative claims and PDMP data (2012 to 2013).SubjectsContinuously enrolled nondually eligible Medicaid beneficiaries who could be linked to the PDMP with two opioid fills covered by Oregon Medicaid.MeasuresPatient characteristics and fill characteristics for opioid fills that lacked a Medicaid pharmacy claim. Fill characteristics included opioid name, type, and association with indicators of high‐risk opioid use.ResultsA total of 33 592 Medicaid beneficiaries filled a total of 555 103 opioid prescriptions. Of these opioid fills, 74 953 (13.5%) could not be matched to a Medicaid claim. Hydromorphone (30%), fentanyl (18%), and methadone (15%) were the most likely to lack a matching claim. The 3 largest predictors for missing claims were opioid fills that overlapped with other opioids (adjusted odds ratio [aOR] 1.37; 95% confidence interval [CI], 1.34‐1.4), long‐acting opioids (aOR 1.52; 95% CI, 1.47‐1.57), and fills at multiple pharmacies (aOR 1.45; 95% CI, 1.39‐1.52).ConclusionsPrescription opioid fills that were likely paid out‐of‐pocket were common and associated with several known indicators of high‐risk opioid use.
Antihypertensive drug associated angioedema: effect modification by race/ethnicity
Authors: Reichman Marsha E. , Wernecke Michael , Graham David J. , Liao Jiemin , Yap John , Chillarige Yoganand , Southworth Mary Ross , Keeton Stephine , Goulding Margie R. , Mott Katrina , Kelman Jeffrey A. 
Published: July 2017

AbstractPurposeAssess angioedema risk with exposure to angiotensin converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) compared with beta‐blockers, by race/ethnicity.MethodsNew‐user cohorts of Medicare beneficiaries 65 years or older initiating ACEI, ARB, or beta‐blocker treatment from March 2007 to March 2014 were constructed. Angioedema incidence rates by drug and race/ethnicity were computed for 1‐30 and 31‐365 days of treatment. Cox proportional hazards regression was used to examine angioedema risk between cohorts.ResultsAngioedema incidence rates (per 1000 person years) in beta‐blocker users were 1.80 (whites), 4.11 (blacks), 1.89 (Asians), and 2.10 (Hispanics); in ACEI users, 4.03, 23.77, 2.94, and 4.27; and in ARB users, 1.73, 3.11, 1.10, and 1.90, respectively. Incidence rates were significantly higher in the first 30 days of exposure for all drug × race/ethnic groups. Overall, angioedema risk increased among ACEI users (hazard ratio, 2.91; 95% confidence interval, 2.75‐3.07) but not ARB users (0.93, 0.85‐1.02) versus beta‐blocker users. Angioedema risk with ACEIs versus beta‐blockers increased more in blacks (6.28, 5.44‐7.24) than whites (2.33, 2.19‐2.48), Hispanics (2.04, 1.36‐3.07), and Asians (1.48, 0.94‐2.35). Compared with white beta‐blocker users, angioedema risk was increased 2.9‐fold in whites, 20.2‐fold in blacks, and 2.3‐fold in other race/ethnic groups combined during the first 30 days of ACEI exposure.ConclusionsThere was significant effect modification of angioedema risk by race and ACEI use for blacks, but not for other race/ethnicity groups. Angioedema risk was significantly greater in the first 30 days of exposure for all, and highest among blacks.
Highly selective enrichment of phosphopeptides by on‐chip indium oxide functionalized magnetic nanoparticles coupled with MALDI‐TOF MS
Authors: Jiang Dandan , Song Naizhong , Li Xiqian , Ma Jiutong , Jia Qiong 
Published: July 2017

AbstractSelective and efficient preconcentration is indispensable for low concentration of phosphopeptides in phosphorylated protein‐related samples prior to MS‐based analysis. Herein, an on‐chip system coupled magnetic SPE with MALDI‐TOF MS was designed. A metal oxide affinity chromatography material, indium oxide, was coated on the surface of Fe3O4 magnetic nanoparticles to prepare the adsorbent, spatially confined with an applied magnetic field. The adsorbent exhibited high selectivity for phosphopeptides in tryptic digests of the mixture of β‐casein and BSA (1:1000) and the mixture of β‐casein, BSA, and ovalbumin (1:100:100). Thanking to the enrichment ability and specificity for phosphopeptides with the adsorbent, the on‐chip magnetic SPE‐MALDI‐TOF MS approach showed high sensitivity with a low detection limit of 4 fmol. In addition, the developed approach was used to analyze phosphopetides in non‐fat milk digests and human serum successfully.