bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Randomized Comparison of Idarubicin and High-Dose Daunorubicin in Induction Chemotherapy for Newly Diagnosed Acute Myeloid Leukemia
Authors: Lee Je-Hwan , Kim Hawk , Joo Young-Don , Lee Won-Sik , Bae Sung Hwa , Zang Dae Young , Kwon Jihyun , Kim Min Kyoung , Lee Junglim , Lee Gyeong Won , Lee Jung-Hee , Choi Yunsuk , Kim Dae-Young , Hur Eun-Hye , Lim Sung-Nam , Lee Sang-Min , Ryoo Hun Mo , Kim Hyo Jung , Hyun Myung Soo , Lee Kyoo-Hyung ,   for the Cooperative Study Group A for Hematology
Published: June 2017

Purpose We compared two induction regimens, idarubicin (12 mg/m2/d for 3 days) versus high-dose daunorubicin (90 mg/m2/d for 3 days), in young adults with newly diagnosed acute myeloid leukemia (AML). Patients and Methods A total of 299 patients (149 randomly assigned to cytarabine plus idarubicin [AI] and 150 assigned to cytarabine plus high-dose daunorubicin [AD]) were analyzed. All patients received cytarabine (200 mg/m2/d for 7 days). Results Complete remission (CR) was induced in 232 patients (77.6%), with no difference in CR rates between the AI and AD arms (80.5% v 74.7%, respectively; P = .224). At a median follow-up time of 34.9 months, survival and relapse rates did not differ between the AI and AD arms (4-year overall survival, 51.1% v 54.7%, respectively; P = .756; cumulative incidence of relapse, 35.2% v 25.1%, respectively; P = .194; event-free survival, 45.5% v 50.8%, respectively; P = .772). Toxicity profiles were also similar in the two arms. Interestingly, overall and event-free survival times of patients with FLT3 internal tandem duplication (ITD) mutation were significantly different (AI v AD: median overall survival, 15.5 months v not reached, respectively; P = .030; event-free survival, 11.9 months v not reached, respectively; P = .028). Conclusion This phase III trial comparing idarubicin with high-dose daunorubicin did not find significant differences in CR rates, relapse, and survival. Significant interaction between the treatment arm and the FLT3-ITD mutation was found, and high-dose daunorubicin was more effective than idarubicin in patients with FLT3-ITD mutation.
Assessment of Postoperative Analgesic Drug Efficacy: Method of Data Analysis Is Critical
Authors: Andersen Lars Peter Kloster , Gögenur Ismail , Torup Henrik , Rosenberg Jacob , Werner Mads Utke 
Published: June 2017

BACKGROUND:
Pain intensity ratings and opioid consumption (OC) are ubiquitous indicators of pain in postoperative trials of the efficacy of interventional procedures. Unfortunately, consensus on the appropriate statistical handling of these outcomes has not been reached. The aim of this article was, therefore, to reexamine original data obtained from a postoperative analgesic drug trial, applying a collection of standard statistical methods in analgesic outcome assessments. Furthermore, a modified integrated assessment method of these outcomes was evaluated.

METHODS:
Data from a randomized, double-blind, placebo-controlled study investigating the analgesic efficacy of a regional anesthetic block following a major elective surgical procedure were analyzed. The original data included measurements of pain intensity (visual analog scale [VAS]) at rest and during coughing (VAS0/2/4/6/12/18/24 h) and OC0
–6/0
–24 h administered by patient-controlled analgesia. The statistical analyses included comparisons of discrete pain intensity scores (VAS0/2/4/6/12/18/24 h), summary measures of pain intensity ratings (area under the curve [AUC]-VAS0
–6/0
–24 h; mean VAS0
–6/0
–24 h), and OC0
–6/0
–24 h. Finally, the analyses also included an integrated assessment of longitudinally measured pain intensity and opioid consumption (PIOC0
–6/0
–24 h). Also, estimation of effect size, generalized odds ratio of the individual analgesic outcome variables was performed.

RESULTS:
Sixty-one patients were included in the final data analysis. Discrete pain intensity ratings differed significantly between the treatment groups at specific postoperative time points, but appropriate correction for multiple comparisons eliminated some of these differences. AUC-VAS0
–6 h differed significantly at rest and during coughing, while no difference was found for AUC-VAS0
–24 h. In contrast, mean VAS0
–6 h and VAS0
–24 h differed significantly between treatment groups at rest and during coughing. OC0
–6/0
–24 h differed significantly between the treatment groups. Finally, also PIOC0
–6/0
–24 h differed significantly at rest and during coughing.

CONCLUSIONS:
Our analyses demonstrate that the applied statistical method may alter the statistical significance and estimates of effect size of analgesic outcome variables in postoperative pain trials. Our findings underline the importance of defining valid statistical methods for future analgesic drug trials. We propose an integrated assessment of longitudinally measured pain intensity and opioid consumption (PIOC). The method combines two interdependent analgesic outcomes, lowers the risk of mass significance, and provides more accurate representation of the dynamic nature of postoperative pain and analgesic drug efficacy.
Administration of Tetrahydrobiopterin (BH4) Protects the Renal Microcirculation From Ischemia and Reperfusion Injury
Authors: Rahmania Lokmane , Orbegozo Diego , Su Fuhong , Taccone Fabio Silvio , Vincent Jean-Louis , De Backer Daniel 
Published: June 2017

BACKGROUND:
Abdominal aortic aneurysm surgery with suprarenal cross-clamping is often associated with renal injury. Although the mechanism underlying such injury is unclear, tissue ischemia and reperfusion, which induces endothelial dysfunction and decreases the availability of tetrahydrobiopterin (BH4), may play a role. We evaluated whether BH4 administration prevents renal ischemia/reperfusion injury in an animal model of aortic cross-clamping.

METHODS:
Nineteen anesthetized, mechanically ventilated, and invasively monitored adult sheep were randomized into 3 groups: sham animals (n = 5) that underwent surgical preparation but no aortic clamping; an ischemia/reperfusion group (n = 7), where the aorta was clamped above the renal arteries for 1 hour, and a BH4 group (n = 7), in which animals received 20 mg/kg of BH4 followed by aortic cross-clamp for 1 hour. Animals were followed for a maximum of 6 hours after reperfusion. The renal microcirculation was evaluated at baseline (before clamping), and 1, 4, and 6 hours after reperfusion using side-stream dark field videomicroscopy. The renal lactate-to-pyruvate ratio was evaluated using microdialysis. The primary outcome was the change in proportion of small perfused vessels before and after injury. Secondary outcomes were renal tissue redox state and renal function.

RESULTS:
Ischemia/reperfusion injury was associated with increases in heart rate and mean arterial pressure, which were blunted by BH4 administration. From the first to the sixth hour after reperfusion, the small vessel density (estimated mean difference [EMD], 1.03; 95% confidence interval [CI], 0.41–1.64; P = .003), perfused small vessel density (EMD, 0.84; 95% CI, 0.29–1.39; P = .005), and proportion of perfused small vessels (EMD, 8.60; 95% CI, 0.85–16.30; P = .031) were altered less in the BH4 than in the ischemia/reperfusion group. The renal lactate-to-pyruvate ratios were lower in the cortex in the BH4 than in the ischemia/reperfusion group from the first to the sixth hour after reperfusion (EMD, −19.16; 95% CI, −11.06 to 33.16; P = .002) and in the medulla from the first to the fourth hour (EMD, −26.62; 95% CI, −18.32 to 38.30; P = .020; and EMD, −8.68; 95% CI, −5.96 to 12.65; P = .019). At the sixth hour, serum creatinine was lower in the BH4 than in the ischemia/reperfusion group (EMD, −3.36; 95% CI, −0.29 to 1.39; P = .026).

CONCLUSIONS:
In this sheep model of renal ischemia/reperfusion, BH4 pretreatment reduced renal microvascular injury and improved renal metabolism and function. Further work is needed to clarify the potential role of BH4 in ischemia/reperfusion injury.
The cell adhesion molecule CHL1 interacts with patched-1 to regulate apoptosis during postnatal cerebellar development
Authors: Katic Jelena , Loers Gabriele , Tosic Jelena , Schachner Melitta , Kleene Ralf 
Published: June 2017

ABSTRACT
The immunoglobulin superfamily adhesion molecule close homolog of L1 (CHL1) plays important roles during nervous system development. Here, we identified the hedgehog receptor patched-1 (PTCH1) as a novel CHL1-binding protein and showed that CHL1 interacts with the first extracellular loop of PTCH1 via its extracellular domain. Colocalization and co-immunoprecipitation of CHL1 with PTCH1 suggest an association of CHL1 with this major component of the hedgehog signaling pathway. The trans-interaction of CHL1 with PTCH1 promotes neuronal survival in cultures of dissociated cerebellar granule cells and of organotypic cerebellar slices. An inhibitor of the PTCH1-regulated hedgehog signal transducer, smoothened (SMO), and inhibitors of RhoA and Rho-associated kinase (ROCK) 1 and 2 prevent CHL1-dependent survival of cultured cerebellar granule cells and survival of cerebellar granule and Purkinje cells in organotypic cultures. In histological sections from 10- and 14-day-old CHL1-deficient mice, enhanced apoptosis of granule, but not Purkinje, cells was observed. The results of the present study indicate that CHL1 triggers PTCH1-, SMO-, RhoA- and ROCK-dependent signal transduction pathways to promote neuronal survival after cessation of the major morphogenetic events during mouse cerebellar development.
Patrimônio histórico cultural: preservar ou transformar? Uma questão conflituosa.
Authors: Lopis Erivania Azevedo 
Published: June 2017

Atualmente o conceito de patrimônio tem sido frequentemente discutido em nossa sociedade. Tanto por diferentes esferas sociais, quanto pelos órgãos de preservação. Isto acontece devido à urgência na salvaguarda de determinados elementos patrimoniais, como também pela recorrente destruição de monumentos/documentos devido às “necessidades” da modernidade. Como entender essa relação tão conflituosa entre o preservar e o transformar? Faz-se mister debater as relações entre o urbanismo – que possui sua própria dinâmica, típica das sociedades modernas – e os elementos patrimoniais que são a representação simbólica de uma identidade, devem coexistir de maneira harmônica para a construção de uma sociedade que cresce e se transforma, mas que também preserva sua memória e sua história enquanto povo. Palavras-chave: Patrimônio, Preservação, Transformação.
A historiografia da Guerra de 1932 e a sua amplitude
Authors: Ribeiro Felipe Castanho 
Published: June 2017

O artigo propõe-se a analisar trabalhos historiográficos envolvendo a Guerra de 1932, mais conhecida como “Revolução Constitucionalista”. Procura-se observar quais foram as principais hipóteses para o advento do conflito, assim como algumas das perguntas que nortearam os trabalhos que versam sobre o tema. A literatura sobre o tema é vasta, no entanto, acredita-se que ainda existem pontos inexplorados pelos historiadores ou que necessitam de um aprofundamento. Palavras-chave: Historiografia, Revolução Constitucionalista de 32, Guerra de 1932, Guerra Nacional.
Supplier Competition with Option Contracts for Discrete Blocks of Capacity
Authors: Anderson Edward , Chen Bo , Shao Lusheng 
Published: June 2017

When a firm faces an uncertain demand, it is common to procure supply using some type of option in addition to spot purchases. A typical version of this problem involves capacity being purchased in advance, with a separate payment made that applies only to the part of the capacity that is needed. We consider a discrete version of this problem in which competing suppliers choose a reservation price and an execution price for blocks of capacity, and the buyer, facing known distributions of demand and spot price, needs to decide which blocks to reserve. We show how to solve the buyer’s (combinatorial) problem efficiently and also show that suppliers can do no better than offer blocks at execution prices that match their costs, making profits only from the reservation part of their bids. Finally we show that in an equilibrium the buyer selects the welfare maximizing set of blocks. The online appendix is available at https://doi.org/10.1287/opre.2017.1593 .
Lovecraftian ontology: Monstrosity, cosmic horror and the Gothic
Authors: Walden Corey R. 
Published: June 2017

Abstract
This article explores the writing of H. P. Lovecraft through portrayals of the monstrous and cosmic horror. Both integral facets of his mythos are connected to his world-view, and then located in terms of wider popular culture and contemporary Gothic scholarship. Lovecraft’s conceptualizations of monstrosity and cosmic horror are seen to be employed in such a way that subverts more conventional forms of storytelling: where many popular culture texts of the twentieth and twenty-first centuries adhere to a mode of storytelling that contains heroism for the protagonist, this is not the case in Lovecraft’s work. Typically phenomena – in the form of cosmic horror and monstrosity – are the focus of the story; yet these manifestations act to form a nexus of expression and critique by utilizing ontological metaphors steeped in meaning.
Regularity results for a priori bounded minimizers of
non-autonomous functionals with discontinuous coefficients
Authors: Giova Raffaella , Passarelli di Napoli Antonia 
Published: June 2017

Abstract
We prove the higher differentiability and the higher integrability
of the a priori bounded local minimizers of integral functionals of
the form

ℱ
⁢

(
v
,
Ω
)

=

∫
Ω

f
⁢

(
x
,

D
⁢
v
⁢

(
x
)

)

⁢

d
x

,

\mathcal{F}(v,\Omega)=\int_{\Omega}f(x,Dv(x))\,{\mathrm{d}}x,

with convex integrand satisfying p-growth conditions with respect to the gradient variable, assuming that the function that measures the oscillation of the integrand with respect to the x-variable
belongs to a suitable Sobolev space. The a priori boundedness of the minimizers allows us to obtain the higher differentiability under a Sobolev assumption which is independent on the dimension n and that, in the case

p
≤

n
-
2

{p\leq n-2}

, improves
previous known results. We also deal with solutions of elliptic systems with discontinuous coefficients under the so-called Uhlenbeck structure. In this case, it is well known that the solutions are locally bounded and therefore we obtain analogous regularity results without the a priori boundedness assumption.
The Aesthetics and Politics of Belonging: National Poets between “Vernacularism” and “Cosmopolitanism”
Authors: Juvan Marko 
Published: June 2017

Abstract
Jameson’s concept of modern third-world literature as national allegory is also pertinent for the 19th-century peripheries of the first-world literature. Aware of their dependence on imperial powers, the protagonists of (semi)peripheral national movements longed for the recognition of their nascent collective identity by the lawgiving Other – the symbolic order of ‘universal’ tradition. The figures of “national poets” (Nemoianu) were invented to represent their respective nations to the gaze of the Other, symbolized by the emerging world literature and empowered through the inter-state system dominated by the core countries. In a secular parallel to the canonization of saints in the Catholic Church, “worlding” (Kadir) a national poet was crucial in the (unfulfilled) longing for his/her universal acknowledgment as belonging to the hyper-canon. While several national poets involved in national movements showed a “vernacular” tendency (Terian), Schiller and Goethe represented the more “cosmopolitan” model of a national classic. Such ‘affiliation’ to the universal aesthetic canon is also characteristic of the politics of Slovenian romantic movement and its poet, France Prešeren. Although Prešeren’s poetry, which was exposed to Austrian censorship, only sparsely employs an explicit political discourse, his imaginary worlding and intertextual transfer of universal aesthetic repertoires from the established literatures into a Habsburg periphery fashioned a cosmopolitan strategy of cultural nationalism. Prešeren has been venerated in Slovenia since the late 19th-century as the singular national classic whose oeuvre compensates for the apparent lack of classical and modern traditions in Slovenian and deserves to be recognized worldwide.
Eine revolutionäre Solitärin?
Authors: Larsson Kristian 
Published: June 2017

Abstract
No systematic investigations of Elfriede Jelinek’s authorial positioning within the hierarchies of the literary field exist. Previous research has nevertheless noted that the authorship is distinguished by a high degree of reflexivity in relation to the power structures it confronts. Studies on the very earliest phase of establishing herself in the Austrian literary field in the years 1966–1969 have, however, emphasized two characteristics: social isolation and literary imitation. Both aspects suggest authorial immaturity if not inferiority, which seems oddly anachronistic and normative given the astonishingly rapid literary success of Jelinek in this period. This article relates the early success to a shift of values in the literary field at the end of the 1960 s, which allowed for new forms of provocative and experimental expressions to generate literary capital. Jelinek’s transgressive authorial dispositions accumulate symbolic capital using a combination of eclectic texts and strategies of self-fashioning within quite diverse contexts, drawing on social networks, media outlets, and literary publications. The theoretical framework primarily draws on concepts developed by Pierre Bourdieu, most notably habitus and symbolic capital.
Effects of environmental parameters on chytrid infection prevalence of four marine diatoms: a laboratory case study
Authors: Scholz Bettina , Vyverman Wim , Küpper Frithjof C. , Ólafsson Halldór G. , Karsten Ulf 
Published: June 2017

AbstractThe influence of environmental factors on the infection susceptibility of four different marine diatom host species to chytrid infection was tested under laboratory conditions, using host and parasite isolates obtained from diverse coastal areas in north-west Iceland in 2015. Specifically, a total of 120 monoclonal marine diatom host cultures of
Thermal characterization and flammability of polypropylene containing sepiolite-APP combinations
Authors: Kaynak Elif , Ureyen Mustafa Erdem , Koparal Ali Savaş 
Published: June 2017

AbstractThe effects of sepiolite on fire behavior of ammonium polyphosphate-based intumescent flame retardant (IFR)/polypropylene (PP) were investigated. The disaggregation of sepiolite bundles has been provided by wet-milling as the zeta potential value decreased from −9.6 to −31.3 mV. PP and additives were compounded by a twin-screw extruder and molded by injection. A total additive content of 20 wt% in PP and various proportions of sepiolite (1.0–10.0 wt%) in flame retardant (FR) formulation were studied. The flammability of the samples was measured by limit oxygen index (LOI) test and cone calorimetry. The LOI of neat PP (19%) was increased to 32.2% when sepiolite and IFR were used. The peak heat release rate of neat PP (1566.4 kW/m2) was also significantly reduced (94.7 kW/m2) when sepiolite was added with IFR. Thermal analyses results showed that, at higher temperature (700°C), IFR and sepiolite increased the char residue (9 wt%) compared to neat PP (0 wt%).
zins und gülte
Authors: Peters Ursula 
Published: June 2017

AbstractIn the light of the latest historical discussion on medieval feudalism, which focuses on the economic implications of fief-holding and feudo-vassallic relations, the question is, if and how economic data play a part in the feudality topic of Courtly Romances. Although the courtly authors from time to time provide detailed information on the economics of fief-holding, they are much more interested in the literary topics of personal vassalage and homage. This interest is specifically focused on problems of feudal services, conflicts of fidelity and humiliating acts of subordination.
Real Time Energy Management System for Smart Buildings to Minimize the Electricity Bill
Authors: Chauhan R. K. , Rajpurohit B. S. , Wang L. , Gonzalez Longatt F. M. , Singh S. N. 
Published: June 2017

AbstractThis paper presents a real time price based energy management system for DC microgrid. The DC distribution system is considered as a prospective system according to the increase of DC loads and DC output type distribution energy resources (DERs) such as photovoltaic (PV) systems, battery bank (BB), and hybrid car (HC). The control objective is to achieve the optimal cost of energy. The proposed control scheme is developed based on the source as well as load scheduling of the DC microgrid. The source scheduling algorithm is based on the selection of cheapest power source to supply the load of DC microgrid and achieve the optimal electricity price. The BB and HC charges in regular hours at the less electricity price to supply the future load during the higher electricity price of the public utility. The load scheduling algorithm shifts the deferrable load of the building from peak hours to the regular hours to obtain the lowest cost of energy for the building. The proposed scheme significantly decreases the peak demand, which is the main cause of load shedding. Dynamic simulation is presented to access the control performance with price fluctuations and robustness of the system.
Angst, Anpassung oder Anregung?
Authors: Storeide Anette Homlong 
Published: June 2017

Abstract
During the German occupation of Norway 1940-45, Göring launched a large-scale plan for a massive expansion of the Norwegian light metal industry in order to boost aircraft production for the Luftwaffe. This light metal project developed into the largest economic project in occupied Norway. A case study of the activities of the Norwegian enterprises, investors and industrialists who were involved in the light metal project sheds new light on the economic relations between German and Norwegian actors in occupied Norway. Dominant assumptions of the German occupational regime as a hegemonic force of exploitation, and the light metal project as a solely German initiative are put to question. However, the analysis of the Norwegian actors in the light metal project reveals that Norwegian participants had a leeway of manoeuvre, which they sought to utilize. The activity of Norwegian enterprises, investors and industrialists was characterized not mainly by anxiety or adjustment, but was rather marked by close cooperation with the occupational forces. The German occupation resulted in manifold business opportunities, und the urge for cooperation must be explained by competitive and commercial interests, and economic pragmatism rather than political and ideological motives.