bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract B033: Excessive Chimeric Antigen Receptor signaling correlates with poor clinical outcomes
Authors: Draper Isabella , Bueter Eric , Annesley Colleen , Summers Corinne , Gardner Rebecca , Smith Stephen 
Published: October 2024

Abstract
While CAR-T clinical trials have seen promising results in B-acute lymphoblastic leukemia (B-ALL), unpredictable side effects, such as Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS), limit CAR-T cells from becoming a first line treatment. Different CAR designs produce different in-human responses, but extant preclinical assays largely fail to predict clinical responses and toxicity. Here, we present data from two independent studies in which we compared the molecular signal transduction profiles of well-performing vs poorly-performing CARs in the clinic. We identified a consistent set of protein-protein interactions that correlate with both poor response and toxicity in CAR trials. In study #1, healthy donor T cells expressing either the poorly performing anti-CD22 (IgG4 Hinge-CD28TM-41BB-CD3z) PLAT-04 CAR, or the better performing anti-CD22 (CD8 Hinge-CD8TM-41BB-CD3z) PLAT-07 CAR were stimulated for five minutes with CD22. Signal transduction was analyzed using Quantitative Multiplex Immunoprecipitation (QMI), an ELISA-like immunoassay, to quantify 400+ protein-protein interactions in CAR signal transduction. In study #2, patient-matched samples expressing murine scFv anti-CD19 (IgG4 Hinge-CD28TM-41BB-CD3z) PLAT-02 CAR or the more neurotoxic fully human scFv anti-CD19 (IgG4 Hinge-CD28-41BB-CD3z) PLAT-06 CAR were stimulated with CD19 for five minutes and signal transduction was analyzed by QMI. Despite reported poor expansion and clinical responses in patients, the PLAT-04 CAR signaled more strongly through ZAP70, TRAFs, and the LAT signalosome relative to the PLAT-07 CAR. The PLAT-06 CAR, which induced high rates of neurotoxicity in patients, also signaled more strongly through ZAP70, GRAP2, and TRAFs than the clinically successful and less toxic PLAT-02 CAR. LAT signalosome formation was similar in both the PLAT-06 and PLAT-02 CARs. These data suggest that poor CAR performance may stem from hyper-activated signaling. Both poorly-performing CARs, despite representing distinct outcomes (poor tumor killing or severe toxicity), signaled more strongly through T cell activating pathways than the optimal-performing CARs. These studies also suggest that variation in non-costimulatory CAR domains (scFv, hinge, TM) contribute to differential CAR signaling. Further studies correlating CAR design with signal transduction and clinical outcomes will allow for the design of safer and more effective CARs.
Citation Format: Isabella Draper, Eric Bueter, Colleen Annesley, Corinne Summers, Rebecca Gardner, Stephen Smith. Excessive Chimeric Antigen Receptor signaling correlates with poor clinical outcomes [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2024 Oct 18-21; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2024;12(10 Suppl):Abstract nr B033.
Abstract B060: Enhanced therapeutic efficacy of a bioflavonoid loaded lipid nanoparticles via remodeling tumor microenvironment (TME) and KEAP1-NRF2 signaling in a murine breast tumor model
Authors: Sunita Priyashree , Sahu Rosa , Pattanayak Shakti P 
Published: October 2024

Abstract
Investigations on bioactive phytoconstituents, especially bioflavonoids and their role in the mitigation of breast cancer have directed our interest to 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one or taxifolin (TX) which possesses potent chemotherapeutic potential in murine breast cancer model. However, it has been observed to possess poor aqueous solubility and thus truncated bioavailability which limit its pharmacological efficacy. The current study focuses on engineering a stable lipid nano-cargo with sufficient entrapment efficiency for hydrophobic TX to produce significantly improved anti-breast cancer activity. The TX-nanoliposomes were exhaustively characterized through various physico-chemical parameters (hydrodynamic particle size and zeta potential, FT-IR, XRD, TGA, DSC, FESEM etc.) and subjected to various in vitro, in vivo and molecular biology studies for efficacy. While the nano-cargo formulation showed enhanced cytotoxicity than raw bioflavonoid against breast cancer, its cytocompatibility as well as hemocompatibility evinced further preclinical investigations. This non-leaky, lipid nano-shuttle, owing to its optimal release kinetics and passive targeted delivery of TX augmented the chemotherapeutic potential against breast cancer through modulating the tumor microenvironment (TME) with infiltration of dominant CD3+/CD8+T-cells along with iNOS+M1-macrophages and Keap1-Nrf2 antioxidant signaling (within the cells). The current study proves that TX-nano cargo enhanced the chemotherapeutic efficacy against breast cancer by improving bioavailability and targeting delivery, leading to TME-remodeling.
Citation Format: Priyashree Sunita, Rosa Sahu, Shakti P Pattanayak. Enhanced therapeutic efficacy of a bioflavonoid loaded lipid nanoparticles via remodeling tumor microenvironment (TME) and KEAP1-NRF2 signaling in a murine breast tumor model [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2024 Oct 18-21; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2024;12(10 Suppl):Abstract nr B060.
Characterising the contribution of auditory and somatosensory inputs to TMS-evoked potentials following stimulation of prefrontal, premotor, and parietal cortex
Authors: Biabani Mana , Fornito Alex , Goldsworthy Mitchell , Thompson Sarah , Graetz Lynton , Semmler John G. , Opie George M. , Bellgrove Mark A. , Rogasch Nigel C. 
Published: October 2024

Abstract
Transcranial magnetic stimulation (TMS) results in a series of deflections in electroencephalography (EEG) recordings known as a TMS-evoked potential (TEP). However, it remains unclear whether these responses reflect neural activity resulting from transcranial stimulation of the cortex, the sensory experiences of TMS, or a combination of the two. Across three experiments (total n = 135), we recorded EEG activity following TMS to the dorsolateral prefrontal cortex, premotor cortex, and parietal cortex as well as a sensory control condition (stimulation of the shoulder or electrical stimulation of the scalp with a click sound). We found that TEPs showed a stereotypical frontocentral N100/P200 complex following TMS of all cortical sites and control conditions, regardless of TMS intensity or the type of sensory control. In contrast, earlier TEPs (&lt;60 ms) showed site-specific characteristics which were largest at the site of stimulation, although TEP topographies were distorted in a subgroup of individuals due to residual TMS-evoked muscle artefact despite cleaning with independent component analysis. Self-reported sensory experiences differed across sites, with prefrontal stimulation resulting in stronger auditory (click sound perception) and somatosensory input (scalp muscle twitch, discomfort) than premotor or parietal stimulation, a pattern that was reflected in the amplitude of later (N100/P200), but not earlier (&lt;60 ms), TEP peak amplitudes. Later TEPs were also larger in individuals who experienced stronger click sound perception and, to a lesser extent, TMS-evoked scalp muscle twitches. Increasing click sound perception by removing auditory masking increased N100/P200 amplitudes without altering earlier peaks, an effect which was more prominent at sites with more successful masking. Together, these findings suggest that the frontocentral N100/P200 complex primarily represents a generalised sensory response resulting from TMS-related auditory and somatosensory input when present. In contrast, early TEP peaks likely primarily reflect activity resulting from transcranial stimulation of the cortex when artefacts were adequately accounted for. The results have important implications for designing and interpreting TEP studies, especially when comparing TEPs between stimulation sites and participant groups showing differences in sensory experiences following TMS.
Arbitrary methodological decisions skew inter-brain synchronization estimates in hyperscanning-EEG studies
Authors: Zimmermann Marius , Schultz-Nielsen Kathrine , Dumas Guillaume , Konvalinka Ivana 
Published: October 2024

Abstract
Over the past decade, hyperscanning has emerged as an important methodology to study neural processes underlying human interaction using fMRI, EEG, fNIRS, and MEG. However, many methodological decisions regarding preprocessing and analysis of hyperscanning data have not yet been standardized in the hyperscanning community, yet may affect inter-brain estimates. Here, we systematically investigate the effects common methodological choices can have on estimates of phase-based inter-brain synchronization (IBS) measures, using real and simulated hyperscanning (dual) EEG data. Notably, we introduce a new method to compute circular correlation coefficients in IBS studies, which performs more reliably in comparison to the standard approach, showing that the conventional circular correlation implementation leads to large fluctuations in IBS estimates due to fluctuations in circular mean directions. Furthermore, we demonstrate how short epoch durations (of 1 s or less) can lead to inflated IBS estimates in scenarios with no strong underlying interaction. Finally, we show how signal-to-noise ratios and temporal factors may confound IBS estimates, particularly when comparing, for example, resting states with conditions involving motor actions. For each of these investigated effects, we provide recommendations for future research employing hyperscanning-EEG techniques, aimed at increasing validity and replicability of inter-brain synchronization studies.
Mind-Body Dualism, Health, and Well-being in University Students
Authors: McGhee C. M. , Gelman Susan A. , Stewart Abigail J. 
Published: October 2024

Abstract
Mind-body dualism conceptualizes mind and body as distinct, but there are different ways that dualism may be instantiated. In this study, we examined how Hierarchical Dualism (the belief that mind and body are distinct, and the mind is superior) and Mutual-Influence Dualism (the belief that mind and body are separate but interrelate) related to health behaviors and mental health in three student samples: exclusively queer, exclusively straight, and a mixed university subject pool (N = 535). Participants in each sample endorsed Mutual-Influence Dualism at a higher rate than Hierarchical Dualism. Mutual-Influence dualism was consistently associated with greater engagement in health-promoting behaviors and greater well-being, whereas Hierarchical Dualism differed by sample. These results suggest that dualist beliefs do not uniformly shape the lives of those who hold them: rather, the relation between dualist beliefs and health differs as a function of the type of dualism and the identities we hold.
Are There Any True Formal Models of Success- and Prestige-Biased Social Learning?
Authors: Cruz y Celis Peniche Patricio 
Published: October 2024

Abstract
Cultural transmission theorists have proposed there is an inherent tradeoff between social learning strategies [SLS s] that rely on direct observation of a cultural variant’s payoffs (i.e., direct bias) and those that rely on a model’s cues of success or prestige (i.e., indirect bias). While the former relies on higher-quality informational goods, a model’s success or prestige cues may be easier to access. This paper reviews mathematical models that have purported to capture indirect bias, and shows they fail to capture this tradeoff, instead making assumptions that reduce their transmission dynamics to those of a direct bias. I include a simple agent-based model to illustrate that their formal equivalence, and therefore our ability to conclude that success and prestige bias are adaptive SLS s, depends on a high correlation between success/prestige cues and a model’s payoffs. This suggests the importance of empirically ascertaining how learners evaluate a model’s fitness, and how they mitigate the risks of biasing their learning on payoff-correlates rather than payoffs themselves. Exploring the cognition underlying these decisions may shed light on maladaptive social learning.
Unveiling the acoustic repertoire of true boas: hisses resemble white noise and indicate individual identity
Authors: Citeli Nathalie K. , Silva-Jr Edvaldo F. , Meneses Afonso S.O. , Santos Maria Laura S. , Gonzalez Rodrigo C. , Rodrigues Anna C.V.S. , de-Carvalho Mariana , Maranhão Ednilza , Brandão Reuber A. , Diniz Pedro 
Published: October 2024

Abstract
Although hissing is a common strategy of defence used by snakes, especially of the Phytonidae and Boidae families, few studies have described in detail the acoustics components of this behaviour. Here we gathered eight recordings from six different boas from Brazil and extracted acoustic measurements from their hissing sounds. We also examined the potential of our measurements to encode individual identity using discriminant function analyses (DFAs) and to correlate with body length using linear mixed models (LMMs). Boas produce from four to 12 hisses per minute (7.13 ± 3.04) evoked by a negative stimulus, a visual looming stimulus generated by researcher’s approach. Each hiss usually has two parts (the first louder part and the second softer part) that are basically broadband white noises split by a short silent interval. The first hiss part also has more frequency modulations and narrower bandwidth than the second hiss part. The DFAs correctly assigned all hisses to their correspondent individuals in the testing data. The first discriminant function explained most of the variance (⩾84%) in the discrimination between groups for the entire hiss and for both hiss parts in the training data subset. Frequency parameters and spectral entropy (for entire hiss and hiss part 1) and the mean frequency and duration (for hiss part 2) were the strongest absolute loadings in the DFAs. Intraspecific morphological traits (e.g. sexual dimorphism and ontogenetic variations) may influence the sound parameters, as detected by individual variations and the tendency for larger individuals to produce lower frequency hisses. Further studies may investigate these aspects in detail, including anatomy of the snake’s larynx and experiments with different types of predators.
Towards a New Reconstruction of the Proto-Yeniseian Sound System. Part II: Word-Final Consonants
Authors: Hill Eugen , Fries Simon , Korobzow Natalie , Günther Laura , Bonmann Svenja 
Published: October 2024

Abstract
We present correspondence sets involving word-final consonants and including all known members of the Yeniseian language family. A systematic application of the Comparative Method to these data yields the following results: (I) three different correspondence sets and, accordingly, three different Proto-Yeniseian phonemes each must be assumed for both Southern Ket word-final -t and -l’, (II) two different correspondence sets and, accordingly, two different Proto-Yeniseian phonemes must be assumed for Southern Ket word-final -s’, (III) the data indicate that one of the two Proto-Yeniseian liquids/rhotics developed in a similar way in Kott, Arin and Pumpokol. We do not see evidence for the postulation of lateral affricates, retroflex sounds or labialised velars as assumed for Proto-Yeniseian by S. Starostin or E. J. Vajda on macro-comparative grounds. The Proto-Yeniseian phonological system that can be reconstructed using Yeniseian data alone is simpler than previously published reconstructions of the Proto-Yeniseian phoneme inventory.
The Multiplicity of Abortion Pills: Considering the Public Constructions of ru486 in Sweden
Authors: Ramsey Morag 
Published: October 2024

Abstract
To this day, abortion pills are a contentious technology – used freely and legally in some countries while prohibited in others. Previous scholarship has shown abortion pills to be difficult to integrate into medical systems. Available since the early 1990s, little has been written on the early adoption of abortion pills in Sweden, one of the first countries to register the compound ru486 for use. This is remarkable if we consider what is at stake when introducing new abortion technologies – namely, the conditions for gender equality and the very tangible implications for maternal health. This article examines the Swedish process of acquiring ru486: mapping the varied actors invested in its use, and analysing the different constructions of abortion pills that were made in these networks. It argues that earlier reproductive research initiatives and their extensive press coverage helped to make registration possible for ru486 in the early 1990s. Comparisons between the constructions of ru486 in Canada and the U.S. illustrate a few key differences between the countries and show why, despite many similarities, Sweden was the first to officially acquire the drug.
Household heroines
Authors: Noorman Judith 
Published: October 2024

Abstract
This essay is about the discovery of Maria van Van Nesse’s ledger, which was hidden in a Belgian family archive. With 123 mentions of paintings and drawings, listed among over 3,500 household expenses, Van Nesse instantly became the best documented art buyer of the seventeenth-century Republic, regardless of gender. This essay compares her impact on the art market with that of her sister, Adriana. Furthermore, by applying household consumption theory to art history, and by adding a gender dimension to socio-economic studies, this essay studies the behavioral patterns and decision-making process underlying the purchase of paintings for the household. In so doing, it sheds new light on the market for luxury goods, including artworks, and the retail landscape.
The images and interventions of Adriana Perez in the Rockox Collection
Authors: Grimmett Kendra 
Published: October 2024

Abstract
Adriana Perez (1568–1619), an affluent woman from Antwerp, who belonged to a prosperous family of Spanish merchants, was the wife of burgomaster Nicolaas Rockox for 30 years. While her husband is celebrated for his patronage of Peter Paul Rubens and for his enviable collection of paintings, sculptures, coins, and books, evidence of Perez’s interventions can be found throughout the Rockox Collection. This article analyzes Perez’s marriage contract, will, two portraits, and the inscription that she contributed to Rockox’s friendship book to bring the elite lady out from her husband’s shadow and to place her at his side as a companion and partner. By reexamining her biography and the married couple’s shared commissions and collection, this paper investigates Adriana Perez’s roles as a co-patron of and audience for the artworks that she and her husband purchased and displayed in their household and over their tomb.
Cultivating a female presence in the early eighteenth-century learned community
Authors: van Deinsen Lieke 
Published: October 2024

Abstract
During the early modern period, printed portraiture became increasingly crucial for shaping the public image of scholars. But what if your appearance didn’t fit the ideal image of a scholar, yet you still sought to be recognized in scholarly circles? This article examines the case of Maria de Wilde, daughter of the renowned Amsterdam collector of antiquities Jacob de Wilde, to reveal the strategies learned women and their advocates employed to navigate this challenge. By analyzing how her portraits were crafted and contributed to her perceived credibility within the learned community, I argue that these portraits could play a crucial role in women’s pursuit of acceptance in the male-dominated scholarly world of the late seventeenth and early eighteenth centuries. By blending women’s inherent femininity with their desired intellectual authority in a single visual representation, these portraits served as powerful tools in women’s ongoing quest for intellectual recognition.
Small-Scale Wind Fluctuations within Melting Layers of Winter Storms: Results from WINTRE-MIX
Authors: Zaremba Troy J. , Minder Justin R. , Friedrich Katja 
Published: October 2024

Abstract
Investigations into the melting layer (ML) of winter storms have revealed small-scale fluctuations in the horizontal wind that could significantly affect the surface precipitation type (p-type) and the evolution of the ML. Despite previous evidence of such fluctuations, essential questions remain concerning their characteristics and the forces driving them. Therefore, this study characterizes small-scale horizontal wind fluctuations (<1 km in length with perturbation magnitudes < 3 m s−1) and their environments within the ML of winter storms. This analysis uses data from a scanning X-band Doppler radar collected during the Winter Precipitation Type Research Multiscale Experiment (WINTRE-MIX), conducted during February and March 2022. We present three case studies where small-scale horizontal wind fluctuations are identified using along-radial and along-azimuthal radial velocity perturbations. These cases cover the range of environmental conditions observed during WINTRE-MIX, including (i) a descending ML with change in surface p-type from snow to rain, (ii) a steady ML with a surface p-type transition from freezing rain to rain due to surface cold air erosion, and (iii) a steady ML with a surface p-type transition from freezing rain to ice pellets due to surface cold air advection. Forcing mechanisms for small-scale wind fluctuations during each case are attributed to static instability, vertically trapped gravity waves, and/or shear instability inferred from rawinsonde data, HRRR analysis, and radar data. Our findings suggest that static instability, gravity waves, and shear instability drive the ML’s small-scale wind fluctuations and may influence surface precipitation-type transitions.

Significance Statement
This research aims to enhance our understanding of horizontal motions (<1 km in length) within melting layers (MLs) of winter storms and their underlying causes. This study uses radar data to detect differences in horizontal motion within the ML of three different winter storms. Weather balloon observations and output from computer weather forecasts are then used to distinguish between horizontal motions generated by convection, vertically trapped gravity waves, or shear. Our findings reveal that horizontal motions within the ML are generated by different forcing mechanisms within different storms and that horizontal motions may influence the surface p-type.