bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Education Capacity of One Regional Physical Therapist Consortium: A Centralized Placement Process Case Report
Authors: Bayliss Jamie , Howman Janice , McIntyre Karen , Renner Trisha A. , Matson Alison 
Published: October 2024

Background and Purpose.
It has been suggested that capacity for physical therapy clinical education (CE) experiences is limited; however, data remain unavailable. Regional CE networks have been suggested and may facilitate data collection and management of capacity issues. The Ohio Kentucky Consortium of Physical Therapy Programs developed a Consortium Core Network (CCN) from shared partnerships and implemented a centralized placement process. The purpose of this case report is to begin to describe the capacity of one regional consortium in terms of its demand, supply, and utilization of CE experiences.

Case Description.
A centralized placement process was implemented in 2022 using Exxat while retaining autonomy for sites and programs. Sites affiliated with 2 or more of the Consortium's 14 physical therapist academic programs (n = 364) were invited to participate, with 101 opting in. Academic programs maintained their individual processes with nonparticipants.

Outcomes.
Data obtained provide a description of regional CE capacity for 2023. Demand was 2353 CE experiences; total supply obtained was 4,193, with 19% offered on a “first-come, first-served” basis and 24% obtained through the CCN. Within the centralized process, all academic programs received offers. Outpatient (66%) and terminal experiences (42%) were most plentiful. Overall utilization of CCN offers was 54%, with greater use of inpatient (82%), first (68%), and program-specific (63%) offers.

Discussion and Conclusion.
This collaborative process provided novel data valuable in understanding regional physical therapist CE capacity. Although the total supply obtained seems to exceed demand, alignment between offer type (level, setting, “first-come, first-served” designation) and needs of individual programs and students must be considered further.
Anatomical Feasibility of Endobentall Strategies for Management of Acute type A Aortic Dissection
Authors: Vallée Aurelien , Guimbretière Guillaume , Guihaire Julien , Guery Antoine , Gaillard Maira , Thomas Le Houerou , Gaudin Antoine , Ramadan Ramzi , Phillippe Deleuze , Maurel Blandine , Roussel Jean Christian , Ghostine Said , Vincentelli André , Juthier Francis , Fabre Dominique , Sobocinski Jonathan , Haulon Stephan 
Published: October 2024

Objectives:
This study assesses the feasibility of acute type A dissections treatment with a dedicated aortic root endograft concept and introduces a new aortic classification.

Summary Background Data:
Acute type A aortic dissection (ATAAD) remains a catastrophic aortic condition with perioperative mortality ranging from 12% and 20%. Total Aortic root endovascular repair, “Endobentall concept”, has been explored as an alternative but only documented on case report.

Methods:
Imaging study of all consecutive patients treated in three French centers were achieved. The study introduces an adapted aortic classification to report entry tear locations. Measurements included aortic annulus mensuration, coronary height, and several aortic lengths. Two treatment concepts were described “fenestrated Endobentall” and “branched Endobentall”. Patients were eligible to the “fenestrated endobentall” design if their aortic root dimensions fitted the Edwards Sapien® and Corevalve Medtronic® instruction for use. Eligibility for the "branched Endobentall" required meeting the criteria for a "fenestrated Endobentall" and having a left coronary main stem length exceeding 5 mm. “Branched Endobentall” was mandatory when the entry was located in the aortic root.

Results:
A total of 250 CT scans for acute type A aortic dissection were reviewed, 116 were finally included for analysis. The primary entry tear was found in the aortic root in 9% of patients, and in 31% of cases, it was located within the first centimeter distal to the sinotubular junction (STJ). 63.7% of the patients were eligible for an Endobentall procedure, even 73.3% when considering extended criterion. Fenestrated Endobentall accounted for 2/3 of cases.

Conclusion:
In our study, 63.7% of patients with aortic type A dissections are deemed eligible to an “Endobentall repair”, increasing to 73.3% when considering extended anatomical criteria.
Dedicated Chest Wall Injury Program quality review: How to create and incorporate a quality and safety program for surgical stabilization of rib fractures
Authors: Sanderfer V. Christian , Davis Joshua , Green John , Thomas Bradley , Rex Kathy , Sachdev Gaurav , Dieffenbaugher Sean , Cunningham Kyle , Lauer Cynthia , Torres Fajardo Rafael , Kuppler Christopher , Cirone Justin , Ross Samuel W. 
Published: October 2024

BACKGROUND
Adoption of surgical stabilization of rib fractures (SSRF) in chest trauma necessitates outcomes reviews and process improvement (PI). As volume and complexity increase, such vigilance is imperative. Over 10 years, our center has developed a dedicated PI program based on our trauma PI program. Here, we outline the components of this program, aiming to share best practices and potentially improve SSRF patient outcomes.

METHODS
Over 10 years, our dedicated SSRF PI process has evolved to include bimonthly reviews on case and quality metrics. In 2022, all patients at our single high-volume Level 1 trauma center with flail chest segments were identified, and a PI chart review was conducted. Data collected included management approach (operative vs. nonoperative), postoperative complications, mortality, patient demographics, trauma specific variables (Injury Severity Score, etc.), and rib fracture details. Operative data collected included number of ribs plated, system used, and complication rates for each surgeon and plating system used.

RESULTS
Of 82 patients identified, 88% underwent SSRF. Among these, 49% experienced one or more postoperative complications, not all directly related to SSRF procedures. Mortality rate for SSRF patients was 15%, predominantly in those with Injury Severity Score of >25 and mean age of 58 years. Patients who had trauma activations and required emergency department chest tube placement had higher complications. The mean number of ribs stabilized was four. Complications occurred more frequently with posterior fractures. Outcomes were collated and analyzed at SSRF Outcomes Committee.

CONCLUSION
The utilization of SSRF underscores the need for a rigorous quality review process to enhance patient safety and SSRF-specific outcomes. Our program developed over time from and was implemented in fashion similar to the trauma PI processes. The resulting quality initiative has fostered center-specific PI projects and programmatic advancements.

LEVEL OF EVIDENCE
Economic and Value-Base Evaluations; Level IV.
Data Hunters: bridging bioinformatics education and microbiome research
Authors: Fumagalli Sara , Armanni Alice , Casiraghi Maurizio , Corneo Luca , Ghisleni Giulia , Labra Massimo , Bruno Antonia 
Published: October 2024

AbstractVast sequencing data in public repositories offer researchers unprecedented opportunities for gaining insights through reanalysis and machine learning approaches, thereby advancing the microbiology field. However, the lack of standardized metadata poses a significant obstacle to big data reuse, necessitating advanced bioinformatics skills for curation and integration.To tackle this challenge, we organized the Data Hunters Workshop, enabling extensive human skin microbiome metadata curation through student community engagement. The Data Hunters Workshop constitutes a student-science initiative within the University of Milano-Bicocca, Italy. Integrating theoretical and hands-on phases, the workshop’s structure included a 6-hour lecture, covering metagenomics and metadata manipulation fundamentals, followed by an interactive practical phase designed as a learn-and-play activity. This phase was supported by in-house developed educational online and command-line resources, facilitating students’ acquisition of Python commands for managing microbiome metadata. Upon the workshop’s conclusion, its effectiveness was assessed through surveys and standardized evaluation scales.Twenty-nine students addressed the critical challenge of metagenomics metadata standardization. Workshop’s resources have equipped students with foundational knowledge in metagenomics and Python programming, empowering them to curate metadata from 379 amplicon-based and shotgun sequencing projects of the human skin microbiome. The collaborative endeavors of these students will ensure the construction of a curated metadata collection.The Data Hunters Workshop established a reusable model for similar educational aims, facilitating metagenomics and bioinformatics teaching and metadata curation. It bridged education and microbiome research by focusing on human skin microbiome metadata curation, ultimately striving to construct a specific collection promptly accessible to researchers.
State and trait serotonin variations interact to shape the intrinsic connectivity and gradient architecture of the brain – a combined TPH2 genetics and tryptophan depletion study
Authors: Wang Lan , Liu Congcong , Xu Ting , Gan Xianyang , Kendrick Keith , Zhao Weihua , Montag Christian , Becker Benjamin 
Published: October 2024

AbstractBackgroundSerotonin (5-HT) critically regulates cognitive and emotional functions, and both stable and transient variations in 5-HT signaling have been associated with emotional dysregulations. However, findings regarding the neurofunctional effects of transient 5-HT variations have been highly inconsistent. Therefore, we examined whether individual variations in a central 5-HT-regulating genetic polymorphism (tryptophan hydroxylase 2, TPH2) represent a vulnerability or resilience factor for the effects of acute tryptophan depletion (ATD) on functional brain architecture.MethodThe current study utilized a pharmacogenetic within-subject randomized placebo-controlled resting-state fMRI design with n=53 healthy male participants in combination with spontaneous intrinsic neural activity, functional connectivity, and connectome gradient analyses to compare the neurofunctional effects of ATD-induced transient reduction in central 5-HT signaling between TPH2 genotypes (a priori genotyping for rs4570625, GG n = 25 vs. TT n = 23).ResultsATD induced significant increases in spontaneous neural activity in hippocampal CA1 irrespective of genotype and enhanced communication of this region with the bilateral amygdala and the vmPFC specifically in GG carriers. ATD sharpened the intrinsic connectome gradient architecture in several large-scale networks, including the salience, frontoparietal, and default mode network.ConclusionsOur results identify a potential genetic marker for an increased vulnerability to the neural effects of transient variations in 5-HT signaling on the functional architecture of an anxiety- and stress-related brain circuit. Connectome gradient results underscore the regulatory role of 5-HT on the intricate organization of large-scale networks involved in emotional reactivity and regulation.
Vaccine failure mode determines population-level impact of vaccination campaigns during epidemics
Authors: Lee Da In , Nande Anjalika , Anderson Thayer L , Levy Michael Z , Hill Alison L 
Published: October 2024

AbstractVaccines are a crucial tool for controlling infectious diseases, yet rarely offer perfect protection. “Vaccine efficacy” describes a population-level effect measured in clinical trials, but mathematical models used to evaluate the impact of vaccination campaigns require specifying how vaccines fail at the individual level, which is often impossible to measure. Does 90% efficacy imply perfect protection in 90% of people and no protection in 10% (“all-or-nothing”), or that the per-exposure risk is reduced by 90% in all vaccinated individuals (“leaky”), or somewhere in between? Here we systematically investigate the role of vaccine failure mode in controlling ongoing epidemics. We find that the difference in population-level impact between all-or-nothing and leaky vaccines can be substantial when R0is higher, vaccines efficacy is intermediate, and vaccines slow but can’t curtail an outbreak. Comparing COVID-19 pandemic phases, we show times when model predictions would have been most sensitive to assumptions about vaccine failure mode. When determining the optimal risk group to prioritize for limited vaccines, we find that modeling a leaky vaccine as all-or-nothing (or vice versa) can change the recommended target group. Overall, we conclude that models of vaccination campaigns should include uncertainty about vaccine failure mode in their design and interpretation.
Maternal high-fat, high-sucrose diet-induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation
Authors: Bellissimo Christian J. , Ribeiro Tatiane A. , Yeo Erica , Jazwiec Patrycja A. , Luo Howard , Bains Jaskiran , Sloboda Deborah M. 
Published: October 2024

ABSTRACTMaternal excess adiposity (i.e., overweight and obesity) at conception is linked to numerous signs of malperfusion and inflammatory injury in the placenta. Previous reports have suggested that obesity-associated placental malperfusion may trigger a state of fetoplacental hypoxia, contributing to adverse health outcomes within and beyond the perinatal period. However, many previous studies have relied on indirect measures of tissue oxygen saturation, including readouts influenced by external inflammatory stressors. Direct comparisons of tissue oxygen saturation at the uteroplacental interface in pregnancies complicated by excess adiposity are lacking. Here, we used a mouse model of chronic preconception high-fat, high-sucrose (HFHS) diet feeding to model the impacts of an obesogenic milieu on placental oxygenation near term gestation (E17.5). We found that both placental junctional and labyrinth zone tissues were relatively hypoxic in HFHS pregnancies compared to chow-fed controls (CON). However, this was not associated with enhanced HIF-1α expression in labyrinth tissues. Similarly, placentas from CON and HFHS dams did not exhibit gross differences in morphology or vessel density and pericyte coverage. However, HFHS placentas have a greater burden of histopathological lesions, including tissue calcification and fibrinoid deposition within the labyrinth zone. Calcified placental tissue coincided with the destruction of vasculosyncytial membranes and macrophage-dense foci, alongside altered expression of immunomodulatory and chemotactic cytokines within the labyrinth zone proteome, which differed in magnitude with fetal sex. While fetal growth was not markedly affected, fetuses from HFHS pregnancies exhibited higher levels of circulating IL-6, prolactin, CXCL1, and CCL2. Collectively, these data confirm that diet-induced maternal excess adiposity leads to a relative state of placental hypoxia, even in the absence of marked growth restriction or fetal demise. While this hypoxic state is not linked to gross morphological abnormalities, it is associated with a greater histopathological burden indicative of local malperfusion and inflammation, and an altered fetal inflammatory and endocrine milieu in late gestation. These findings provide new insight into mechanisms by which an obesogenic environment during pregnancy compromises placental function and contributes to the long-term programming of chronic disease susceptibility.
Real-time study of the interplay between phase formation and stress evolution at the
W1−xSix/a−Si
interface
Authors: Krause Bärbel , Furgeaud Clarisse , Mastail Cédric , Michel Anny , Parent Salomé , Abadias Gregory , Resta Andrea , Coati Alessandro , Garreau Yves , Vlad Alina 
Published: October 2024

Nanoscale W1−xSix layers with different Si content were deposited by magnetron sputtering on amorphous silicon layers. The structure and stress evolution during deposition were monitored and in real time. Thus, it was possible to disentangle different origins of stress built-up (interface formation, phase formation, grain growth, and texture) on the nanoscale. It was found that the bcc phase with a composition-dependent texture forms at low Si content (less than 10% Si), but only above a critical thickness. At intermediate Si content (13.9% and 16.5% Si), or low Si content and low thicknesses (≲4.5 nm), the β phase with A15 structure and coexisting phases (bcc or amorphous) form, while a single, amorphous phase is observed at high Si content (≳22% Si). An A15 formation driven by impurities (O,C,N) was excluded by combined x-ray photoelectron spectroscopy and x-ray diffraction measurements on a second sample series. calculations of substitutional bcc and A15 W1−xSix alloys support the formation of A15 at higher Si content. The A15-containing interlayer should be taken into account when discussing the superconductivity of W/Si multilayers. The stress evolution during deposition of W1−xSix was correlated with the microstructure evolution, and compared to similar observations for Mo1−xSix. Due to the crystalline phase (bcc/A15) and bcc texture ([111] and [110]) competition, the structure formation of W1−xSix shows a higher complexity. This explains the wide range of stress states (from tensile to compressive) observed after deposition of W1−xSix. Nanoscale W-Si based stress-compensation layers could be employed for tailoring the stress state of nonepitaxial semiconductor devices.

Published by the American Physical Society
2024
The interactive effect of products and consumption frequency on happiness in China
Authors: Jin Yufang 
Published: October 2024

PurposeA substantial portion of existing literature on comparing experiential and material purchases on happiness indicates an experiential advantage. However, this advantage is presumed to occur in developed countries, with developing countries being overlooked. To address this gap in the literature, this paper examines the effect of consumption in China. It introduces a new perspective, consumption frequency (ordinary vs extraordinary), to investigate the interactive effect of consumption frequency (ordinary vs extraordinary) and product type (material vs experiential) on happiness and to explore the underlying mechanisms in China.Design/methodology/approachThe study constructs a model about the interactive effect of consumption frequency (ordinary vs extraordinary) and product type (material vs experiential) on happiness and takes self-expansion as the underlying mechanism. The authors employ two experiments and a nationwide secondary survey dataset to test the model.Findings(1) consumption frequency and product type can interactively improve happiness significantly in China; (2) extraordinary material consumption induces a higher level of happiness than extraordinary experiential consumption and (3) these effects are driven by self-expansion, which is an important character for people in developing countries.Research limitations/implicationsThis study is incomplete in its lack of investigation into the boundary conditions, such as materialism in the model.Originality/valueThis paper introduces a novel perspective, consumption frequency and integrates it with existing research variables (material vs experiential) to propose the interactive effect and the underlying mechanism, self-expansion. This paper contributes to the theory of consumption happiness by introducing the concept of consumption frequency in the comparison of material versus experiential products on happiness. Conversely, our findings contribute to the understanding of happiness in China.
Effects of foundation pit excavation on adjacent metro stations and shield tunnel structures: a study on horizontal displacement
Authors: Wei Gang , Mu Zhiyuan , Feng Weihao , Qi Yongjie , Guo Binglai 
Published: October 2024

PurposeThe aim of this study is to investigate the horizontal displacement effects of foundation pit excavation on adjacent metro stations and shield tunnel composite structures. It seeks to develop a theoretical calculation method capable of accurately assessing these engineering impacts, aiming to provide practical assistance for engineering applications.Design/methodology/approachThis study introduces a model for shield tunnel segments incorporating rotation and misalignment, considering the constraints of metro stations. It establishes a displacement model for tunnel-station combinations during foundation pit excavation, deriving a formula for calculating station-proximal tunnel horizontal displacements. The method's accuracy is validated against field data from three engineering cases. The research also explores variations in tunnel displacement, inter-ring shear force, misalignment and rotation angle under different spatial relationships between pits, tunnels and stations.FindingsThis study models uneven deformation between stations and tunnels due to bending stiffness and shear constraints. It enhances the misalignment model with station-induced shear effects and introduces coefficients for their mutual interaction. Results show varied responses based on pit-station-tunnel positioning: minimal displacement near pit edges (coefficients around 0.1) and significant effects near pit centers (coefficients from 0.4 to 0.5). “Whip effect” from station constraints affects tunnel displacement, shear force, misalignment and rotation, with fluctuations decreasing with distance from excavation areas.Originality/valueThis study demonstrates significant originality and value. It introduces a novel displacement model for tunnel-station combinations considering station constraints, addressing theoretical calculations of horizontal displacement effects from foundation pit excavation on metro stations and shield tunnel structures. Through validation with field data and parameter studies, the concept of influence coefficients is proposed, offering insights into variations in structural responses under different spatial relationships. This research provides crucial technical support and decision-making guidance for optimizing designs and facilitating practical construction in similar engineering projects.
Fostering sustainability in the healthcare organization through green HRM practices: the mediation analysis of perceived organizational support
Authors: Sarwar Adnan , Shahzad Saqib 
Published: October 2024

PurposeThis study aims to investigate the influence of green human resource management (GHRM) practices on healthcare organization sustainability performance in Pakistan. It explores how perceived organizational support (POS) mediates the relationship between GHRM practices and healthcare organizational sustainability.Design/methodology/approachIn the quantitative method, a questionnaire was used to acquire the perception of individuals via a simple random method. A total of 320 questionnaires were collected from the employees in the healthcare organizations of Pakistan, with a 47.70% response rate. Hypotheses were tested using SmartPLS (PLS-SEM).FindingsThe results reveal a positive relationship between GHRM practices and healthcare organization sustainability performance. POS partially mediated the relationship, strengthening the effectiveness of GHRM practices in boosting organizational sustainability.Originality/valueThe present study contributes to the understanding of GHRM practices in the healthcare industry, particularly in the context of emerging nations like Pakistan. It demonstrates a novel mediation role of POS to bolster the effectiveness of GHRM practices for gaining sustainability performance. The research proposes significant insight for both scholars and practitioners on how supportive corporate cultures affect the GHRM initiatives that foster economic, environmental and social sustainability.