bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topical oxygen therapy promotes the healing of chronic diabetic foot ulcers: a pilot study
Authors: Hayes P.D. , Alzuhir N. , Curran G. , Loftus I.M. 
Published: November 2017

Objective: Interventions that can heal or reduce diabetic foot ulcer (DFU) size may reduce the incidence of infection and amputation, and reduce associated social and economic costs. Many chronic wounds exhibit a degree of hypoxia and this leads to a reduction in healing processes including cell division and differentiation, angiogenesis, infection prevention, and collagen production. The aim of this pilot study was to assess the effects of a device supplying continuous oxygen ambulatory therapy on healing in chronic DFUs. Method: Patients with chronic DFUs from two tertiary referral hospitals in the UK received treatment with the device. Data were prospectively obtained on wound size using standardised digital images measured by a clinician blinded to the study. Data on device satisfaction and pain were also obtained. Results: We recruited 10 patients, with a mean ulcer duration of 43 weeks (median: 43 weeks) before treatment. By week eight, mean ulcer size had decreased by 51% (median: 53%). Seven of the 10 ulcers were in a healing trajectory, one ulcer present for 56 weeks healed completely, a two-year old ulcer was reduced by more than 50%, and a third, present for 88 weeks, was down to 10% of its original size by the end of the eight-week study. There was also a non-significant trend towards reduction in pain and the device was extremely well tolerated. Conclusion: The ambulatory topical oxygen delivery device showed a significant beneficial effect on wound size. This poses practical advantages over currently existing oxygen-based wound therapies such as hyperbaric oxygen therapy due to its continuous oxygen delivery, ease of use, safety and lower cost. The results of this study warrant further review of the device in comparison to standard wound therapies.
PEMILIHAN KEPALA DESA SERENTAK DALAM PERSPEKTIF OTONOMI DESA (Studi Kasus Pelaksanaan Pemilihan Kepala Desa Serentak Tahun 2016 di Kabupaten Rokan Hilir, Provinsi Riau)
Authors: . Rudiadi , Herawati Ratna 
Published: November 2017

Era reformasi yang terjadi pada tahun 1998 menandai berakhirnya Pemerintahan Orde Baru, hal inilah yang melatar belakangi lahirnya otonomi daerah dan UU No.22 Tahun 1999 Tentang Pemerintahan Daerah. Perjalanan sistem otonomi daerah terus mengalami perubahan, hal itu ditandai dengan lahirnya UU No.32 Tahun 2004 dan UU No.23 Tahun 2014 Tentang Pemerintahan Daerah. Lahirnya UU No.23 tahun 2014 ini menjadi dasar lahirnya UU No.6 Tahun 2014 Tentang Desa, hal itu semakin memperkuat status desa sebagai pemerintahan yang memiliki hak otonomi yang asli dan demokratis. Lahirnya UU Desa ini menjadi dasar hukum mengenai pemilihan Kepala Desa (Pilkades) serentak di Indonesia, seperti yang disebutkan dalam Pasal 31 ayat (1). Metode pendekatan yang digunakan dalam penelitian ini adalah metode pendekatan Yuridis Empiris, spesifikasi penelitian adalah Deskriptif Analitis dan data yang digunakan data pri,er dan sekunder. Hasil analisa penelitian menyimpulkan: peraturan tentang Pilkades pasca Era reformasi diatur dalam UU No.22 tahun 1999 dan UU No.32 tahun 2014 tentang Pemerintahan Daerah. Namun setelah lahirnya UU No.6 tahun 2014 tentang Desa, pelaksanaan Pilkades dilaksanakan secara serentak diseluruh wilayah di Indonesia, seperti yang disebutkan dalam Pasal 31 ayat (1). Selain itu, pelaksanaan Pilkades serentak di Kabupaten Rokan Hilir, Provinsi Riau, tahun 2016 terdapat beberapa permasalahan: adanya aturan persyaratan pencalonan yang dikhususkan untuk Calon Kepala Desa yang beragama Islam, yaitu “dapat membaca al-quran”, sedangkan bagi Calon Non-muslim tidak diatur persyaratan tersebut. Hal itu mengindikasikan adanya diskriminatif dalam agama, serta dapat merusak proses demokrasi di desa. Permasalahan lain yang terjadi adalah, adanya campur tangan Panitia Kabupaten secara langsung dalam proses seleksi bakal Calon Kepala Desa. Selain itu, pelaksanaan Pilkades serentak dilihat dalam perspektif otonomi desa, idealnya semua tahapan dalam pemilihan dan juga tahapan penyeleksian Bakal Calon diserahkan kepada Panitia Pemilihan di desa.
PUTUSAN ULTRA PETITA MAHKAMAH KONSTITUSI DALAM PENGUJIAN UNDANG-UNDANG (SUATU PERSPEKTIF HUKUM PROGRESIF)
Authors: Sasmito Heri Abduh 
Published: November 2017

Doktrin larangan ultra petita bagi hakim tidaklah berlaku mutlak dan umum. Dengan menggunakan pendekatan normatif dan penafsiran sistemik dapat dikatakan bahwa ketentuan dalam Undang-Undang MK maupun Peraturan MK tidak memberikan kemungkinan bagi hakim konstitusi untuk membuat putusan ultra petita. Dalam menerbitkan putusan yang mengandung ultra petita, pada umumnya MK mendasarkan adanya keterkaitan yang tidak terpisahkan antara pasal yang diuji dengan pasal-pasal lain yang tidak diuji, sehingga karenanya pasal atau seluruh undang-undang tersebut harus dinyatakan tidak berkekuatan hukum, di samping karena alasan untuk menghindari kekacauan hukum dan menegakkan keadilan subtantif. Terobosan MK dalam membuat putusan ultra petita pada prinsipnya adalah bentuk dari penegakan hukum yang progresif, akan tetapi kreatifitas apapun yang dilakukan oleh penegak hukum dapat menjadi tidak bermakna progresif manakala tidak untuk mewujudkan keadilan subtantif, menempatkan keadilan, kemanfaatan dan kebahagiaan manusia sebagai tujuan akhirnya. Kata kunci : Ulta Petita, Pengujian Undang-Undang, Hukum Progresif.
Investigating the differential effects of social networking site addiction and Internet gaming disorder on psychological health
Authors: Pontes Halley M. 
Published: November 2017

Background and aims
Previous studies focused on examining the interrelationships between social networking site (SNS) addiction and Internet gaming disorder (IGD) in isolation. Moreover, little is known about the potential simultaneous differential effects of SNS addiction and IGD on psychological health. This study investigated the interplay between these two technological addictions and ascertained how they can uniquely and distinctively contribute to increasing psychiatric distress when accounting for potential effects stemming from sociodemographic and technology-related variables.

Methods
A sample of 509 adolescents (53.5% males) aged 10–18 years (mean = 13.02, SD = 1.64) were recruited.

Results
It was found that key demographic variables can play a distinct role in explaining SNS addiction and IGD. Furthermore, it was found that SNS addiction and IGD can augment the symptoms of each other, and simultaneously contribute to deterioration of overall psychological health in a similar fashion, further highlighting potentially common etiological and clinical course between these two phenomena. Finally, the detrimental effects of IGD on psychological health were found to be slightly more pronounced than those produced by SNS addiction, a finding that warrants additional scientific scrutiny.

Discussion and conclusion
The implications of these results are further discussed in light of the existing evidence and debates regarding the status of technological addictions as primary and secondary disorders.
The importance of research literacy for yoga therapists
Authors: Moonaz Steffany , Jeter Pamela , Schmalzl Laura 
Published: November 2017

Abstract
Evidence-Informed Practice (EIP) utilizes the three components of expert opinion, research evidence, and client values. It is a recommended training competency for integrative health practitioners in diverse fields, such as acupuncture and massage therapy. Research Literacy (RL) is a necessary pre-requisite to EIP. Many yoga therapists have limited training in these skills, which negatively impacts inter-professional communication and collaboration, as well as further advancement of yoga therapy research and practice. In this article, we propose inclusion of RL and EIP in the training of yoga therapists. Benefits for client care, collaborative care, and the field of yoga therapy are discussed.
Conservation laws for a Boussinesq equation.
Authors: Gandarias M.L. , Bruzón M.S. 
Published: November 2017

Abstract
In this work, we study a generalized Boussinesq equation from the point of view of the Lie theory. We determine all the low-order conservation laws by using the multiplier method. Taking into account the relationship between symmetries and conservation laws and applying the multiplier method to a reduced ordinary differential equation, we obtain directly a second order ordinary differential equation and two third order ordinary differential equations.
UAE New Drilling Record
Authors: Allahyarov Rashad , Al Khatib Osama , Bermudez Romulo 
Published: November 2017

Abstract
This development, predominantly from four artificial islands, of a giant offshore field in the United Arab Emirates (UAE) requires Extended Reach Drilling (ERD) well design including extended length liners in order to reach drilling and geological targets of the field and Maximum Reservoir Contact (MRC) well design that can drastically decrease development costs.
Despite drilling challenges during well construction process such as losses in UER, shallow aquifer flows in Simsima, key seating issues in the base of Simsima, wellbore instability in Laffan and Nahr Umr shale, losses in Salabikh and etc. the team has managed to deliver the longest well to date in UAE to a depth of 35,800 feet and has set many ZADCO internal records for drilling performance with no HSE events.
Through the use of enabling best practices, lessons learnt and new technologies such as Casing Swivel, Fixed-Bonded non-rotating centralizers and 21 days swell packers, the well was drilled and completed 11.3 days under Authorization for Expenditure (AFE). Several major milestones and records were achieved such as record drilling performance (spud to TD), longest 8 ½" hole section (18,800 feet) with one Bit and Bottom Hole Assembly (BHA), 16" surface hole inclination of 56°, deepest set 9 ⅝" casing to 17,000 feet MD, longest single stage 6 ⅝" liner in the world (total length of 19,004 feet at the time).
All well objectives have been achieved. Several technologies were deployed to enable the abovementioned records including the use of Fixed-Bonded non-rotating centralizers in tandem with sacrificial casing swivel.
MICROBIAL OXIDATION OF FINASTERIDE WITH MACROPHOMINA PHASEOLINA(KUCC 730)
Authors: Erum Saira , Sultan Sadia , Shah Syed Adnan Ali , Ashraf Muhammad , Choudhary Muhammad Iqbal 
Published: November 2017

Objectives: New microbial oxidative derivatives of Finasteride [17β-(N-tert-butylcarbamoyl)-4-aza-5α-androst-1-en-3-one] (1) has been investigated with Macrophomina phaseolina (ATCC730).Methods: Fermented media of Macrophomina phaseolina (ATCC730) was prepared to cultivate the fungal cultures . Substrate 1 was incubated in liquid media for 16 days. After sixteen days, filtration and extraction of the fermented media was carried out with 9 L DCM in three portions. Resulting organic extract was dried using anhydrous (Na2SO4), and evaporated to afford a brown gum (950 mg). This on chromatographic purification with MeOH in CH2Cl2 afforded the metabolites 2-4 . Results: Three oxidised metabolites of finasteride (1) which were identified as 15-oxo-finasteride (2), 11a-hydroxyfinasteride (3), and 15β-hydroxyfinasteride (4). Metabolite 2 was found to be new. The structure of the oxidised metabolites were elucidated by 1-D (1H, 13C) and 2-D NMR (COSY, HMBC, HMQC, NOESY) techniques and MS analyses.Conclusion: As a result of these study, oxidation at C-7, C-11 and C-15 positions were found. Metabolite 2 was identified as a new metabolite.
IN VIVO ANTICANCER EVALUATION OF (2-AMINO-3,4,5-TRIMETHOXYPHENYL) (6-METHOXY-1H-INDOL-3-YL) METHANONE
Authors: Patel Vijay K. , Rajak Harish 
Published: November 2017

Objective: The design and development of Combretastatin A-4 analogues as anticancer agent has always attracted the attention of scientific community involved in anticancer research. The aim of the present work was to investigate the in-vivo cytotoxic activity of a novel CA-4 analogues i.e., (2-amino-3,4,5-trimethoxyphenyl)(6-methoxy-1H-indol-3-yl)methanone.Method: The in-vivo cytotoxic activity of test compound was examined using Human Tumor Xenograft model on MCF-7 cancer cell line in Balb/c mice.Result: The test compound exhibited excellent cytotoxic activity against MCF-7 (0.013 µM), and colon HT-29 (0.143 µM), slightly higher than CA-4 activity. Relative Tumor Volume (RTV) value was found to increase rapidly in control group A during the period of 1 to 18 days indicating the higher growth rates of tumor. On the other hand group B and C showed slower growth rate of tumor as a result of treatment with CA-4 and test compound, respectively. The group B treated with CA-4 (5 mg/kg) showed significant inhibition in tumor growth during day 5 to 18 with %TGI in range of 47.24%-62.31% as compared to control group. The group C treated with test compound (5mg/kg) caused significant inhibition in tumor growth during day 5 to 18 with %TGI in range of 55.66%-75.93% as compared to control group. The % survival value was found 100% indicating that CA-4 and test compound were nontoxic at the dose of 5mg/kg under experimental conditions.Conclusion: The parameters of In-vivo anticancer evaluation i.e., relative tumour volume and % tumor growth inhibition showed better anticancer potential of test compound. It was further supported by non-toxic nature of test compound as indicated by 100% survival value determined at the dose of 5 mg/kg during in-vivo studies.
EVALUATION OF CYTOTOXIC AND GENOTOXIC EFFECTS OF ZERUMBONE ON COLON ADENOCARCINOMA COLO205 CELLS AND HUMAN LYMPHOCYTES
Authors: Thiyam Rima , Narasu Mangamoori Lakshmi 
Published: November 2017

Objective: The objective of the present study was to investigate the growth inhibitory effect, apoptosis initiation and genotoxic effect of zerumbone (ZER), a phytochemical and cisplatin, a chemotherapeutic drug on human colorectal cancer cell line COLO205 and normal human lymphocytes.Methods: The antiproliferative activity of ZER and cisplatin (positive control) on COLO205 cells and lymphocytes was analysed by 3( 4, 5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) assay. Morphological analysis of the cells was studied by using inverted phase contrast microscope. Propidium iodide staining method was used to observe the apoptotic morphological changes in the treated cells. Finally comet assay was conducted to observe the extent of DNA damage induced by ZER and cisplatin on COLO205 and lymphocytes.Results: ZER and cisplatin exhibited growth inhibition in a dose and time dependent manner against COLO205 with no considerable effect on lymphocytes. The IC50 values of ZER on COLO205 for 24h, 48h and 72h were 19 µg/ml, 10 µg/ml and 5 µg/ml. Comparatively the IC50 values of cisplatin on COLO205 for 24h, 48h and 72h were 38 µg/ml, 24 µg/ml and 15 µg/ml. Morphological changes such as cell shrinkage, membrane blebbing and nuclear condensation were observed in COLO205 while no significant change was observed in lymphocytes. Fluorescence imaging studies confirmed apoptotic cell death in treated COLO205 cells while no significant cell death was observed in treated lymphocytes. Comet assay revealed significant DNA damage in treated COLO205 cells.Conclusion: The present study demonstrated the cytotoxic and genotoxic effect of ZER and cisplatin on COLO205 cells. These drugs showed no significant effect on lymphocytes.
Properties of Whistler Waves in Warm Electron Plasmas
Authors: Zhao Jinsong 
Published: November 2017

Abstract
Dispersion relation and electromagnetic properties of obliquely propagating whistler waves are investigated on the basis of a warm electron fluid model. The magnetic field of whistler waves is nearly circularly polarized with respect to the wave vector in a plasma where the electron plasma frequency

is much larger than the electron cyclotron frequency

, and the magnetic field polarization can become elliptical, or even linear, polarization as

. In the plasmas with

, the resonant frequency is about

, which is different from

predicted by the cold electron fluid model. Near the resonant frequency, the whistler wave approximates a quasi-magnetostatic mode, not a quasi-electrostatic mode in the cold electron plasmas. Moreover, the detailed mode properties are given in Earth’s magnetosphere, the solar active region, and Jupiter’s polar cap. Furthermore, the study proposes that the ratio of the electrostatic to electromagnetic component of the electric field can be used to distinguish the whistler mode from the Z-mode in the frequency range of

in the solar active region and Jupiter’s polar cap.
Pediatric Orbital Primitive Neuroectodermal Tumors
Authors: Afghani Tayyab , Mansoor Hassan , Raza Hamdani Syed Naeem 
Published: November 2017

Purpose:
To present the clinical, radiological, histopathological, immunohistochemical features and the follow-up of orbital primitive neuroectodermal tumors (PNETs) in pediatric patients along with a review of the literature.

Methods:
A retrospective analysis of all diagnosed cases of orbital PNET was done. Patients' ophthalmic findings, imaging, immunohistochemistry, metastatic work-up, treatment, globe salvation, and survival were documented and a mini literature review of orbital PNET was performed.

Results:
Four diagnosed cases of orbital PNET presented with proptosis and visual impairment were treated during the study period. The radiological imaging showed primary orbital involvement. There were three males and one female with a mean age of 63.75 months (range: 3 to 244 months). Histopathology of all studied patients showed round malignant cells with hyperchromatic nuclei, increased nuclear cytoplasmic ratio, and positive test results for CD99 and FLI-1. The studied patients underwent orbital surgery for excision of tumors followed by chemotherapy. One of the patients also had external radiation in addition to chemotherapy after a second recurrence. The follow-up period of these patients varied from 1 to 5 years. Only one child who had recurrence twice was followed up to 5 years, but was lost to follow-up after that.

Conclusions:
The authors believe that most orbital peripheral PNET tumors present as well-defined masses on both imaging and perioperatively and are easily removed surgically. The apparently disguised “benign profile” of orbital PNET may prove deceptive and the shorter duration of symptoms remains a strong reminder of the malignant nature of the lesion.

[
J Pediatr Ophthalmol Strabismus.
2018;55(2):128-134.]
Between primitive and 2-transitive: Synchronization and its friends
Authors: Araújo João , Cameron Peter J. , Steinberg Benjamin 
Published: November 2017

An automaton (consisting of a finite set of states with given transitions) is said to be synchronizing if there is a word in the transitions which sends all states of the automaton to a single state. Research on this topic has been driven by the
Černý conjecture
, one of the oldest and most famous problems in automata theory, according to which a synchronizing

n

-state automaton has a reset word of length at most

(n-1)^2

.The transitions of an automaton generate a transformation monoid on the set of states, and so an automaton can be regarded as a transformation monoid with a prescribed set of generators. In this setting, an automaton is synchronizing if the transitions generate a constant map.

A permutation group

G

on a set

\Omega

is said to synchronize a map

f

if the monoid

\langle G,f\rangle

generated by

G

and

f

is synchronizing in the above sense; we say

G

is synchronizing if it synchronizes every non-permutation.

The classes of synchronizing groups and friends form an hierarchy of natural and elegant classes of groups lying strictly between the classes of primitive and 2-homogeneous groups. These classes have been floating around for some years and it is now time to provide a unified reference on them.
The study of all these classes has been prompted by the Černý conjecture, but it is of independent interest since it involves a rich mix of group theory, combinatorics, graph endomorphisms, semigroup theory, finite geometry, and representation theory, and has interesting computational aspects as well. So as to make the paper self-contained, we have provided background material on these topics.
Our purpose here is to present recent work on synchronizing groups and related topics. In addition to the results that show the connections between the various areas of mathematics mentioned above, we include a new result on the Černý conjecture (a strengthening of a theorem of Rystsov), some challenges to finite geometers (which classical polar spaces can be partitioned into ovoids?), some thoughts about infinite analogues, and a long list of open problems to stimulate further work.
Playing Shakespeare
Authors: Barton John 
Published: November 2017

John Barton is Advisory Director at the Royal Shakespeare Company and has directed some of the greatest Shakespeare productions of our time. His book, Playing Shakespeare, is a transcript of his televised workshops with some of our finest Shakespearean actors: Peggy Ashcroft, Judi Dench, Ian McKellen, Ben Kingsley, Patrick Stewart and David Suchet. "What the programmes and published text reveal, is the method and principle approach of acting Shakespeare which has been fundamental to the Royal Shakespeare Company since it was formed" Trevor Nunn.
This new edition contains a DVD with 80mins of video featuring John Barton in conversation with Judi Dench, Ian McKellen, Patrick Stewart and Jane Lapotaire discussing changes in approaches to Shakespeare's text since the book first published. This edition also features a foreword by Michael Boyd.
A highly readable and non-academic approach to understanding Shakespeare's text - unlocking the hidden stage directions and actors clues that reside in his verse. "When an actor becomes aware of them, s/he will find that Shakespeare himself starts to direct them" John Barton.
Working in American Theatre
Authors: Voltz Jim 
Published: November 2017

“I cannot think of a better book for aspiring and working actors, craftspeople, artists, and managers” Kent Thompson, Artistic Director, Denver Center Theatre Company, Past President TCG Board of Directors
“It’s time for a new look at the complexity and richness of America’s growing theatrical landscapre and Jim Volz is just the person to provide that overview” Lesley Schisgall Currier, Managing Director, Marin Shakespeare Company
Working in American Theatre is a coast-to-coast overview of the opportunities awaiting theatre practitioners in every discipline.
Featuring tips from America’s top theatre professionals, this resource offers job-search and career-planning strategies, as well as detailed information on over 1,000 places to work in the American theatre, including regional companies, Broadway and commerical theatre, Shakespeare festivals, touring theatres, university/resident theatres, youth and children’s theatres, and outdoor theatres. Offering an overview of the evolution of American theatre and behind-the-scenes stories of the regional movement, this single volume is an indispensable tool at every stage of your career.