bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perinatal psychiatric episodes: a population-based study on treatment incidence and prevalence
Authors: Munk-Olsen T , Maegbaek M L , Johannsen B M , Liu X , Howard L M , di Florio A , Bergink V , Meltzer-Brody S 
Published: October 2016

AbstractPerinatal psychiatric episodes comprise various disorders and symptom severity, which are diagnosed and treated in multiple treatment settings. To date, no studies have quantified the incidence and prevalence of perinatal psychiatric episodes treated in primary and secondary care, which we aimed to do in the present study. We designed a descriptive prospective study and included information from Danish population registers to study first-time ever and recurrent psychiatric episodes during the perinatal period, including treatment at psychiatric facilities and general practitioners (GPs). This was done for all women who had records of one or more singleton births from 1998 until 2012. In total, we had information on 822 439 children born to 491 242 unique mothers. Results showed first-time psychiatric episodes treated at inpatient facilities were rare during pregnancy, but increased significantly shortly following childbirth (0.02 vs 0.25 per 1000 births). In comparison, first-time psychiatric episodes treated at outpatient facilities were more common, and showed little variation across pregnancy and postpartum. For every single birth resulting in postpartum episodes treated at inpatient psychiatric facilities, 2.5 births were followed by an episode treated at outpatient psychiatric facility and 12 births by GP-provided pharmacological treatment. We interpret our results the following way: treated severe and moderate psychiatric disorders have different risk patterns in relation to pregnancy and childbirth, which suggests differences in the underlying etiology. We further speculate varying treatment incidence and prevalence in pregnancy vs postpartum may indicate that the current Diagnostic and Statistical Manual of Mental Disorders-5 peripartum specifier not adequately describes at-risk periods across moderate and severe perinatal psychiatric episodes.
Netzwerkanalysen in der regionalen Versorgungsforschung: Das Beispiel der dermatologischen Versorgung in der Metropolregion Hamburg
Authors: Augustin J. , Austermann J. , Erasmi S. 
Published: October 2016

Zusammenfassung
Ziel der Studie: Übergeordnetes Ziel des Gesetzgebers ist es, eine „homogene“, flächendeckende und wohnortnahe medizinische Versorgung der Bevölkerung sicher zu stellen. Zur Beschreibung der regionalen Versorgungssituation kann der Versorgungsgrad (Bedarfsplanungs-Richtlinie des Gemeinsamen Bundesausschusses) herangezogen werden, allerdings kann er keine Auskunft über die Erreichbarkeit des bspw. nächstgelegenen Arztes geben. Hierzu eignen sich Netzwerkanalysen. Mittels eines Fallbeispiels werden anhand der regionalen dermatologischen Versorgungssituation in der Metropolregion Hamburg Anwendungsmöglichkeiten von Netzwerkanalysen zur Analyse der regionalen Versorgungssituation vorgestellt.
Methodik: Um die regionale dermatologische Versorgungssituation einordnen zu können, wurde zunächst der Versorgungsgrad berechnet. Für die anschließende Netzwerkanalyse mussten die Dermatologen (N=357) in der Metropolregion nach Standorten (N=303) zusammengefasst werden. Vor der Berechnung wurden u. a. die Adressdaten der Ärzte in Koordinaten umgewandelt und Vorschriften (z. B. Geschwindigkeiten) des Netzwerkes festgelegt. Die Berechnung der bevölkerungsbezogenen Anteile der Erreichbarkeit basierte auf der Einwohnerdichte, die mit den Ergebnissen der Netzwerkanalyse verschnitten wurde.
Ergebnisse: Trotz einer insgesamt guten Versorgungssituation sind die Unterschiede in der Erreichbarkeit des nächsten Dermatologen in der Metropolregion beträchtlich. Das ist vor allem dann der Fall, wenn der ÖPNV als Verkehrsmittel dient. Landkreise in denen über 60% der Einwohner mit dem ÖPNV länger als eine Stunde zum nächsten Dermatologen benötigen, wurden identifiziert. Insbesondere ländlich geprägte Regionen innerhalb der Metropolregion sind hiervon betroffen.
Schlussfolgerungen: Die Netzwerkanalyse hat deutlich gemacht, dass die Wahl bzw. Verfügbarkeit des Verkehrsmittels in Kombination mit dem Wohnort (ländlich/städtisch) von wesentlicher Bedeutung für den Zugang zur Versorgung ist. Vor allem ältere, wenig-mobile Menschen auf dem Lande sind damit benachteiligt. Daraus lässt sich die Notwendigkeit moderner Versorgungsansätze, wie bspw. der Telemedizin ableiten, um die Versorgungssituation im ländlichen Raum optimieren zu können. Netzwerkanalysen können einen wertvollen methodischen Beitrag zur Analyse regionaler Versorgungsdisparitäten leisten und bestehende Instrumente, wie den Versorgungsgrad, sinnvoll ergänzen.
Assessing (for) impact: future assessment of the societal impact of research
Authors: Hill Steven 
Published: October 2016

AbstractNational research assessments play a role in providing accountability—to funders, government and civil society—for the activities of largely autonomous research systems. Increasingly, an element of such assessments is the assessment of societal impact. In this article, I review the development of impact assessment, with a focus on the UK’s Research Excellence Framework, and consider implications and challenges for the future. Notwithstanding these challenges, I further argue that the assessment of societal impact needs to become a more central aspect of research evaluation. This article is published as part of a collection on the future of research assessment.
Parasite stress and pathogen avoidance relate to distinct dimensions of political ideology across 30 nations
Authors: Tybur Joshua M. , Inbar Yoel , Aarøe Lene , Barclay Pat , Barlow Fiona Kate , de Barra Mícheál , Becker D. Vaughn , Borovoi Leah , Choi Incheol , Choi Jong An , Consedine Nathan S. , Conway Alan , Conway Jane Rebecca , Conway Paul , Adoric Vera Cubela , Demirci Dilara Ekin , Fernández Ana María , Ferreira Diogo Conque Seco , Ishii Keiko , Jakšić Ivana , Ji Tingting , van Leeuwen Florian , Lewis David M. G. , Li Norman P. , McIntyre Jason C. , Mukherjee Sumitava , Park Justin H. , Pawlowski Boguslaw , Petersen Michael Bang , Pizarro David , Prodromitis Gerasimos , Prokop Pavol , Rantala Markus J. , Reynolds Lisa M. , Sandin Bonifacio , Sevi Bariş , De Smet Delphine , Srinivasan Narayanan , Tewari Shruti , Wilson Cameron , Yong Jose C. , Žeželj Iris 
Published: October 2016

Significance
Pathogens, and antipathogen behavioral strategies, affect myriad aspects of human behavior. Recent findings suggest that antipathogen strategies relate to political attitudes, with more ideologically conservative individuals reporting more disgust toward pathogen cues, and with higher parasite stress nations being, on average, more conservative. However, no research has yet adjudicated between two theoretical accounts proposed to explain these relationships between pathogens and politics. We find that national parasite stress and individual disgust sensitivity relate more strongly to adherence to traditional norms than they relate to support for barriers between social groups. These results suggest that the relationship between pathogens and politics reflects intragroup motivations more than intergroup motivations.
Structural elements of an NRPS cyclization domain and its intermodule docking domain
Authors: Dowling Daniel P. , Kung Yan , Croft Anna K. , Taghizadeh Koli , Kelly Wendy L. , Walsh Christopher T. , Drennan Catherine L. 
Published: October 2016

Significance
Here we investigate the structural basis for cyclization activity in hybrid polyketide synthase-nonribosomal peptide synthetases. This first structure of a cyclization (Cy) domain reveals an unexpected location for the enzyme active site, providing a fresh perspective on past mutational studies. Our structures also depict two 20-Å-long channels that create routes for the two tethered substrates to simultaneously reach the buried active site, affording substrate condensation and cyclization. Along with the Cy domain, these structures contain a covalently attached docking domain, providing insight into how protein modules work together to achieve uni-directionality in the biosynthesis of natural products.
p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome
Authors: Cohen-Kaplan Victoria , Livneh Ido , Avni Noa , Fabre Bertrand , Ziv Tamar , Kwon Yong Tae , Ciechanover Aaron 
Published: October 2016

Significance
Whereas the role of the ubiquitin system in protein degradation is well established, little is known regarding the regulation of its own components, including its catalytic arm, the 26S proteasome. Here we show that in stressed mammalian cells, the proteasome is targeted by autophagy, which requires site-specific ubiquitination of its ubiquitin receptors. The process is mediated by the p62/SQSTM1 adapter and requires its ubiquitin-associated domain. Independently, p62 serves also as a shuttling protein for ubiquitinated substrates, using its PB1 domain. This places p62 in a pivotal position where under certain conditions it binds to the proteasome as a protease, whereas in other conditions it recognizes the proteasome as a prey. The regulation of this intricate “decision making” process remains elusive.
ImpulseDE: detection of differentially expressed genes in time series data using impulse models
Authors: Sander Jil , Schultze Joachim L , Yosef Nir 
Published: October 2016

AbstractSummaryPerturbations in the environment lead to distinctive gene expression changes within a cell. Observed over time, those variations can be characterized by single impulse-like progression patterns. ImpulseDE is an R package suited to capture these patterns in high throughput time series datasets. By fitting a representative impulse model to each gene, it reports differentially expressed genes across time points from a single or between two time courses from two experiments. To optimize running time, the code uses clustering and multi-threading. By applying ImpulseDE, we demonstrate its power to represent underlying biology of gene expression in microarray and RNA-Seq data.Availability and ImplementationImpulseDE is available on Bioconductor (https://bioconductor.org/packages/ImpulseDE/).Supplementary informationSupplementary data are available at Bioinformatics online.
Web-igloo: a web based platform for multivariate data visualization
Authors: Kuntal Bhusan K , Mande Sharmila S 
Published: October 2016

Abstract

Motivation
The majority of data generated routinely from various experiments are essentially multivariate, often categorized with multiple experimental metadata. Analyzing such results with interactive visualizations often yields interesting and intuitive results which otherwise remains undisclosed.

Results
In this paper, we present Web-Igloo—a GUI based interactive ‘feature decomposition independent’ multivariate data visualization platform. Web-Igloo is likely to be a valuable contribution in the field of visual data mining, especially for researchers working with but not limited to multi-omics data. To demonstrate its utility, we have used a metagenomic dataset pertaining to the effect of multiple doses of antibiotic treatment on the human gut microbiome.

Availability and Implementation
http://metagenomics.atc.tcs.com/webigloo and http://121.241.184.233/webigloo [Freely available for academic use].

Supplementary information
Supplementary data are available at Bioinformatics online.
On-the-fly selection of cell-specific enhancers, genes, miRNAs and
proteins across the human body using SlideBase
Authors: Ienasescu Hans , Li Kang , Andersson Robin , Vitezic Morana , Rennie Sarah , Chen Yun , Vitting-Seerup Kristoffer , Lagoni Emil , Boyd Mette , Bornholdt Jette , de Hoon Michiel J. L. , Kawaji Hideya , Lassmann Timo ,   The FANTOM Consortium, Hayashizaki Yoshihide , Forrest Alistair R. R. , Carninci Piero , Sandelin Albin 
Published: October 2016

Genomics consortia have produced large datasets profiling the expression of genes, micro-RNAs, enhancers and more across human tissues or cells. There is a need for intuitive tools to select subsets of such data that is the most relevant for specific studies. To this end, we present SlideBase, a web tool which offers a new way of selecting genes, promoters, enhancers and microRNAs that are preferentially expressed/used in a specified set of cells/tissues, based on the use of interactive sliders. With the help of sliders, SlideBase enables users to define custom expression thresholds for individual cell types/tissues, producing sets of genes, enhancers etc. which satisfy these constraints. Changes in slider settings result in simultaneous changes in the selected sets, updated in real time. SlideBase is linked to major databases from genomics consortia, including FANTOM, GTEx, The Human Protein Atlas and BioGPS.
Database URL: http://slidebase.binf.ku.dk
Photospheric carbon and oxygen abundances of F–G type stars in the Pleiades cluster*
Authors: Takeda Yoichi , Hashimoto Osamu , Honda Satoshi 
Published: October 2016

Abstract
In order to investigate the carbon-to-oxygen ratio of the young open cluster M 45 (Pleiades), the C and O abundances of 32 selected F–G type dwarfs (in the effective temperature range of Teff ∼ 5800–7600 K and projected rotational velocity range of vesin i ∼ 10–110 km s−1) belonging to this cluster were determined by applying the synthetic spectrum-fitting technique to C i 5380 and O i 6156–8 lines. The non-local thermodynamical equilibrium corrections for these C i and O i lines were found to be practically negligible (less than a few hundredths dex).The resulting C and O abundances (along with the Fe abundance) turned out nearly uniform without any systematic dependence upon Teff or vesin i. We found, however, in spite of almost solar Fe abundance ([Fe/H] ∼ 0), carbon turned out to be slightly subsolar ([C/H] ∼ −0.1) while that of oxygen was slightly supersolar ([O/H] ∼ +0.1). This leads to a conclusion that the [C/O] ratio was moderately subsolar (∼ −0.2) in the primordial gas from which these Pleiades stars were formed ∼ 120–130 Myr ago. Interestingly, similarly young B-type stars are reported to show just the same result ([C/O] ∼ −0.2), while rather aged (∼ 1–10 Gyr) field F–G stars of near-solar metallicity yield almost the solar value ([C/O] ∼ 0) on average. Such a difference in the C/O ratio between two star groups of distinctly different ages may be explained as a consequence of the orbit migration mechanism which Galactic stars may undergo over a long time.
Protocol for Psychopharmacologic Management of Behavioral Health Comorbidity in Adult Patients with Diabetes and Soft Tissue Infections in a Tertiary Care Hospital Setting
Authors: Pinkhasov Aaron , Singh Deepan , Kashan Benjamin , DiGregorio Julie , Criscitelli Theresa M. , Gorenstein Scott , Brem Harold 
Published: October 2016

GENERAL PURPOSE:
To provide information about the effect of psychiatric comorbidities on wound healing in patients with diabetes mellitus (DM).

TARGET AUDIENCE:
This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

LEARNING OBJECTIVES/OUTCOMES:
After participating in this educational activity, the participant should be better able to:
1. Discuss the connection between DM and the development of psychiatric comorbidities.
2. Identify the drugs recommended in the treatment of these psychiatric comorbidities.
3. List cautions and contraindications related to the drugs discussed.

ABSTRACT
In patients with diabetes mellitus type 2, psychiatric comorbidities such as depressive and anxiety disorders are 60% or more prevalent than in the general population. The severity of mental illness and the duration of diabetes have been shown to correlate with worsening glycemic control, thus impeding wound healing. A retrospective chart review was conducted in all patients with diabetes mellitus admitted to the wound service with prior or current psychiatric symptoms of anxiety, depression, or cognitive impairment. A psychopharmacologic protocol was developed based on the clinical data collected and treatment parameters used by the behavioral health consultation liaison service.
Survey of Neonatal Intensive Care Unit Nurse Attitudes Toward Therapeutic Hypothermia Treatment
Authors: Craig Alexa , James Christine , Bainter Janelle , Lucas Francis L. , Evans Scott , Glazer John 
Published: October 2016

Background:
The traumatic experiences of parents of babies treated with therapeutic hypothermia (TH) have been described. No research has assessed neonatal intensive care unit (NICU) nurse experience in providing care to hypothermic babies and emotional support to their parents.

Purpose:
To assess NICU nurse attitudes to the provision of TH with respect to perceptions about baby pain/sedation, need for nurse and parent education, decision making about initiation of TH, and barriers to best care.

Methods:
A survey was electronically sent to 219 nurses at 2 affiliated academic level III NICUs: 1 rural and 1 urban location. There were 17 questions where responses were selected from a preset list and 7 opportunities for nurses to provide free text responses.

Findings:
The response rate was 38% (N = 83). Overwhelming similarities between the urban and rural institutions were found with NICU nurses expressing understanding of the indications for initiating TH, agreement that TH improves long-term outcomes and that the benefits of TH outweigh the risks. Nurses at the urban institution more frequently expressed concerns surrounding inadequate treatment of baby pain/sedation, and nurses at both institutions strongly emphasized the need for more nurse and parent education about TH and improved timeliness of decision making for initiation of TH.

Implications for Practice:
NICU nurses specifically want to learn more about outcomes of babies after treatment with TH and feel that parents need more education about TH.

Implications for Research:
Research is urgently needed to better understand the implications of TH treatment for parent–baby bonding.
Smartphone and Internet Preferences of Parents
Authors: Orr Talia , Campbell-Yeo Marsha , Benoit Britney , Hewitt Brenda , Stinson Jennifer , McGrath Patrick 
Published: October 2016

Background:
Despite an abundance of research that identifies the benefits for both parent and child when parents are actively involved in their infant's care, challenges related to the best methods to engage families persist.

Purpose:
To conduct a feasibility study that aims to understand the preferences of smartphone and Internet use by parents of infants admitted to the neonatal intensive care unit (NICU) related to information seeking and active participation in infant care, with a focus on pain management interventions.

Methods:
A paper-based survey was distributed to 90 parents in a tertiary-level NICU from September to November 2013.

Results:
Response rate was 80% (72 of the 90). Ninety-seven percent accessed the Internet daily, 87% using their smartphone, and ranked it as an important source of NICU information (81%), more than books (56%) and brochures (33%). Participants reported a desire to have more information on how they could provide general comfort (96%), as well as greater participation in comforting their baby during painful procedures (94%).

Implications for Practice:
Parents in the NICU want more information and greater involvement in their infant's care and pain management and place a higher value on the Internet compared with traditional resources.

Implications for Research:
Researchers and clinicians should work together to determine the quality of online resources to better support and evaluate parent use of the Internet as a health information resource. Future studies should examine parental preference regarding the optimal balance between online sources and face-to-face interactions.
Association Between the Estrogen Receptor Beta (ESR2) Rs1256120 Single Nucleotide Polymorphism and Adolescent Idiopathic Scoliosis
Authors: Zhao Linlu , Roffey Darren M. , Chen Suzan 
Published: October 2016

Study Design.A systematic review and meta-analysis.Objective.The aim of this study was to assess and synthesize the current evidence on the association between the rs1256120 single nucleotide polymorphism (SNP) of the estrogen receptor beta gene (ESR2) and adolescent idiopathic scoliosis (AIS).Summary of Background Data.Hormonal disturbance has been postulated as a potential etiological factor in the development of AIS. As estrogen receptors are important mediators of estrogen response, mutations in these genes, including rs1256120 ofESR2, have been chosen as susceptibility candidates for AIS predisposition. The association of rs1256120 with AIS has been investigated in several recent studies, but showed conflicting evidence. We conducted a systematic review to evaluate the strength of this body of evidence and quantitative synthesis to examine sources of heterogeneity.Methods.This study conformed to PRISMA guidelines. Using a sensitive search strategy, PubMed (MEDLINE), EMBASE, and HuGE Literature Finder databases were searched to identify relevant studies for inclusion in the systematic review and meta-analysis. Risk of bias was assessed using a modified Newcastle-Ottawa Scale. The inverse variance model was used to calculate summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the allelic (Cvs. T) and genotypic comparisons. Planned subgroup and sensitivity analyses were performed.Results.Three studies were included for systematic review and meta-analysis (n = 1264 AIS cases and n=1020 controls). A null relationship was found between rs1256120 and AIS (allelic OR = 1.20, 95% CI: 0.81–1.78,P = 0.36,I2 = 84.9%), with the first reported association likely to be false-positive and contributing substantially to heterogeneity.Conclusion.Findings from the systematic review and meta-analysis suggest that rs1256120 ofESR2is unlikely to be a predisposing or disease-modifying genetic risk factor for AIS.Level of Evidence:2
Anterior Cingulate Glutamate Is Reduced by Acamprosate Treatment in Patients With Alcohol Dependence
Authors: Frye Mark A. , Hinton David J. , Karpyak Victor M. , Biernacka Joanna M. , Gunderson Lee J. , Feeder Scott E. , Choi Doo-Sup , Port John D. 
Published: October 2016

Abstract
Although the precise drug mechanism of action of acamprosate remains unclear, its antidipsotropic effect is mediated in part through glutamatergic neurotransmission. We evaluated the effect of 4 weeks of acamprosate treatment in a cohort of 13 subjects with alcohol dependence (confirmed by a structured interview, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision) on proton magnetic resonance spectroscopy glutamate levels in the midline anterior cingulate cortex (MACC). We compared levels of metabolites with a group of 16 healthy controls. The Pennsylvania Alcohol Craving Scale was used to assess craving intensity. At baseline, before treatment, the mean cerebrospinal fluid–corrected MACC glutamate (Glu) level was significantly elevated in subjects with alcohol dependence compared with controls (P = 0.004). Four weeks of acamprosate treatment reduced glutamate levels (P = 0.025), an effect that was not observed in subjects who did not take acamprosate. At baseline, there was a significant positive correlation between cravings, measured by the Pennsylvania Alcohol Craving Scale, and MACC (Glu) levels (P = 0.019). Overall, these data would suggest a normalizing effect of acamprosate on a hyperglutamatergic state observed in recently withdrawn patients with alcohol dependence and a positive association between MACC glutamate levels and craving intensity in early abstinence. Further research is needed to evaluate the use of these findings for clinical practice, including monitoring of craving intensity and individualized selection of treatment with antidipsotropic medications in subjects with alcohol dependence.