bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model
Authors: Dargaei Zahra , Bang Jee Yoon , Mahadevan Vivek , Khademullah C. Sahara , Bedard Simon , Parfitt Gustavo Morrone , Kim Jun Chul , Woodin Melanie A. 
Published: January 2018

SignificanceHuntington’s disease (HD) is a fatal neurodegenerative disorder that currently has no cure. Although HD is classically considered a motor disorder, HD patients experience learning and memory deficits years before the onset of motor symptoms, and these deficits resemble those observed in HD mouse models. In this work, using transgenic mouse models of HD, we demonstrate that the action of the neurotransmitter GABA has switched from inhibitory to excitatory. By treating HD mice with a clinically used diuretic (bumetanide), which restores inhibitory GABA, we rescued the learning and memory deficits. Our data suggest a potential therapeutic approach for the treatment of the cognitive deficits in early HD that can improve patient quality of life and reduce caregiver burden.
Report of the key-comparison of spectral diffuse reflectance (EURAMET.PR-K5) (Ref. 619)
Authors: Andor György , Gál Péter 
Published: January 2018

This report details the final results of the EURAMET comparison on regular spectral transmittance carried out between 2006 and 2016.
The aim of this comparison was to check the agreement of measurement of the spectral diffuse reflectance among participants, using the measurement geometry of d/0 or 0/d in the wavelength range of 360 nm to 780 nm at 20 nm increment. We used a star type comparison: first the participants sent their samples to the pilot, than the pilot measured all the samples of the participants and sent them back. The participants measured the samples and sent them to the pilot for control measurement.
Six standards were used as reference standards in order to maintain the scale during the comparison. These were three samples of BCR-406 opal glasses (BCR 30506; BCR 30303; BCR 30704), an MC20 Russian opal glass (MC 4777) and two samples made of pressed halon (polytetrafluoroethylene) powder (halon 2007A; halon 2007C). These six samples were designated as the Comparison reference standards. The diffuse reflectance was initially measured on the OMH (BFKH) absolute reflectometer.
The link to the CCPR-K5 results was BFKH, and the check on BFKH was the PTB results who also participated in the CCPR-K5 comparison.
The participants were GUM, INM, LNE, METAS, BFKH, PTB, SP.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCPR, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Three-dimensional Simulation and Prediction of Solenoid Valve Failure Mechanism Based on Finite Element Model
Authors: Li Jianfeng , Xiao Mingqing , Liang Yajun , Tang Xilang , Li Chao 
Published: January 2018

Abstract
The solenoid valve is a kind of basic automation component applied widely. It’s significant to analyze and predict its degradation failure mechanism to improve the reliability of solenoid valve and do research on prolonging life. In this paper, a three-dimensional finite element analysis model of solenoid valve is established based on ANSYS Workbench software. A sequential coupling method used to calculate temperature filed and mechanical stress field of solenoid valve is put forward. The simulation result shows the sequential coupling method can calculate and analyze temperature and stress distribution of solenoid valve accurately, which has been verified through the accelerated life test. Kalman filtering algorithm is introduced to the data processing, which can effectively reduce measuring deviation and restore more accurate data information. Based on different driving current, a kind of failure mechanism which can easily cause the degradation of coils is obtained and an optimization design scheme of electro-insulating rubbers is also proposed. The high temperature generated by driving current and the thermal stress resulting from thermal expansion can easily cause the degradation of coil wires, which will decline the electrical resistance of coils and result in the eventual failure of solenoid valve. The method of finite element analysis can be applied to fault diagnosis and prognostic of various solenoid valves and improve the reliability of solenoid valve’s health management.
The Study of “big data” to support internal business strategists
Authors: Ge Mei 
Published: January 2018

Abstract
How is big data different from previous data analysis systems? The primary purpose behind traditional small data analytics that all managers are more or less familiar with is to support internal business strategies. But big data also offers a promising new dimension: to discover new opportunities to offer customers high-value products and services. The study focus to introduce some strategists which big data support to. Business decisions using big data can also involve some areas for analytics. They include customer satisfaction, customer journeys, supply chains, risk management, competitive intelligence, pricing, discovery and experimentation or facilitating big data discovery.
The Optimization dispatching of Micro Grid Considering Load Control
Authors: Zhang Pengfei , Xie Jiqiang , Yang Xiu , He Hongli 
Published: January 2018

AbstractThis paper proposes an optimization control of micro-grid system economy operation model. It coordinates the new energy and storage operation with diesel generator output, so as to achieve the economic operation purpose of micro-grid. In this paper, the micro-grid network economic operation model is transformed into mixed integer programming problem, which is solved by the mature commercial software, and the new model is proved to be economical, and the load control strategy can reduce the charge and discharge times of energy storage devices, and extend the service life of the energy storage device to a certain extent.
Evaluation of tools for highly variable gene discovery from single-cell RNA-seq data
Authors: Yip Shun H , Sham Pak Chung , Wang Junwen 
Published: January 2018

Abstract
Traditional RNA sequencing (RNA-seq) allows the detection of gene expression variations between two or more cell populations through differentially expressed gene (DEG) analysis. However, genes that contribute to cell-to-cell differences are not discoverable with RNA-seq because RNA-seq samples are obtained from a mixture of cells. Single-cell RNA-seq (scRNA-seq) allows the detection of gene expression in each cell. With scRNA-seq, highly variable gene (HVG) discovery allows the detection of genes that contribute strongly to cell-to-cell variation within a homogeneous cell population, such as a population of embryonic stem cells. This analysis is implemented in many software packages. In this study, we compare seven HVG methods from six software packages, including BASiCS, Brennecke, scLVM, scran, scVEGs and Seurat. Our results demonstrate that reproducibility in HVG analysis requires a larger sample size than DEG analysis. Discrepancies between methods and potential issues in these tools are discussed and recommendations are made.
Electronic problem lists: a thematic analysis of a systematic literature review to identify aspects critical to success
Authors: Hodge Chad M , Narus Scott P 
Published: January 2018

AbstractObjectiveProblem list data is a driving force for many beneficial clinical tools, yet these data remain underutilized. We performed a systematic literature review, pulling insights from previous research, aggregating insights into themes, and distilling themes into actionable advice. We sought to learn what changes we could make to existing applications, to the clinical workflow, and to clinicians’ perceptions that would improve problem list utilization and increase the prevalence of problems data in the electronic medical record.Materials and MethodsWe followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to systematically curate a corpus of pertinent articles. We performed a thematic analysis, looking for interesting excerpts and ideas. By aggregating excerpts from many authors, we gained broader, more inclusive insights into what makes a good problem list and what factors are conducive to its success.ResultsAnalysis led to a list of 7 benefits of using the problem list, 15 aspects critical to problem list success, and knowledge to help inform policy development, such as consensus on what belongs on the problem list, who should maintain the problem list, and when.ConclusionsA list of suggestions is made on ways in which the problem list can be improved to increase utilization by clinicians. There is also a need for standard measurements of the problem list, so that lists can be measured, compared, and discussed with rigor and a common vocabulary.
Hypertension Among Persons Living With HIV in Medical Care in the United States—Medical Monitoring Project, 2013–2014
Authors: Olaiya Oluwatosin , Weiser John , Zhou Wen , Patel Pragna , Bradley Heather 
Published: January 2018

AbstractHypertension is a leading modifiable risk factor for cardiovascular disease (CVD), and persons living with HIV are at increased risk for both hypertension and CVD. Therefore, using data from a nationally representative sample of patients living with HIV, we assessed missed opportunities for the optimal management of hypertension.
Menstrual Cycle in Women Who Co-use Marijuana and Tobacco
Authors: Lammert Sara , Harrison Katherine , Tosun Nicole , Allen Sharon 
Published: January 2018

Objective:
Marijuana is the most commonly used illicit drug in the United States and co-use with tobacco is increasing. Preliminary studies have indicated that marijuana may suppress luteinizing hormone (LH) or shorten the luteal phase. Although the literature is mixed, these sex hormones may play a role in smoking cessation outcomes. This secondary subgroup analysis aims to explore the menstrual cycle of females who co-use marijuana and tobacco compared with females who only use tobacco in a sample of tobacco treatment-seeking individuals.

Methods:
Female participants, aged 18 to 50 years, who self-reported regular menstrual cycles and co-use of marijuana and tobacco were matched 1:3 by age to participants who only use tobacco. Length of the follicular and luteal phases was determined using First Response Urine LH tests. Wilcoxon 2-sample t tests were used to determine differences in phase lengths between groups.

Results:
Thirteen women who co-use marijuana and tobacco, and 39 women who only use tobacco were included in this analysis. Overall, participants were 37.3 ± 8.0 (SD) years of age, mostly Caucasian (67%), and smoked 12.6 ± 5.2 (SD) cigarettes per day. The luteal phase length among participants who co-use marijuana and tobacco (11.4 days ± 2.2 [SD]) was significantly shorter than among participants who only use tobacco (16.8 days ± 11.3 [SD]; P = 0.002). No differences were found in follicular phase length or menstrual cycle length.

Conclusions:
These data suggest that females who co-use marijuana and tobacco may have a shortened luteal phase in comparison with females who only use tobacco. Further studies are needed to better understand how marijuana use may impact the menstrual cycle and affect smoking outcomes.
Reducing Anxiety and Improving Engagement in Health Care Providers Through an Auricular Acupuncture Intervention
Authors: Buchanan Teresa M. , Reilly Patricia M. , Vafides Carol , Dykes Patricia 
Published: January 2018

Background
Stress and anxiety are experienced by health care providers as a consequence of caregiving and may result in physical, emotional, and psychological outcomes that negatively impact work engagement.

Aim
The purpose of this study was to determine whether auricular acupuncture can reduce provider anxiety and improve work engagement.

Methods
Study participants received 5 auricular acupuncture sessions within a 16-week period utilizing the National Acupuncture Detoxification Association protocol for treating emotional trauma. Each participant completed the State-Trait Anxiety Inventory and the Utrecht Work Engagement Scale (UWES-9) prior to their first session and again after their fifth treatment.

Results
Significant reductions were found in state and trait anxiety (State-Trait Anxiety Inventory), as well as significant increases in the overall scores on the UWES as compared with baseline. Only the dedication subcategory of the UWES showed significant improvement.

Conclusions
Engagement has been linked to increased productivity and well-being and improved patient and organizational outcomes. Providing effective strategies such as auricular acupuncture to support health care providers in reducing anxiety in the workplace may improve engagement.
Early Predictors for Long-Term Functional Outcome After Mild Traumatic Brain Injury in Frail Elderly Patients
Authors: Abdulle Amaal Eman , de Koning Myrthe E. , van der Horn Harm J. , Scheenen Myrthe E. , Roks Gerwin , Hageman Gerard , Spikman Jacoba M. , van der Naalt Joukje 
Published: January 2018

Objective:
To identify the effect of frailty and early postinjury measures on the long-term outcome after mild traumatic brain injury in elderly patients.

Setting:
Patients admitted to 3 Dutch hospitals designated as level 1 trauma centers.

Participants:
The elderly (≥60 years) with mild traumatic brain injury (N = 161).

Design:
A prospective observational cohort study.

Main Measures:
Posttraumatic complaints and the Hospital Anxiety and Depression Scale determined 2 weeks postinjury; the Glasgow Outcome Scale Extended and Groningen frailty indicator determined 1 to 3 years postinjury.

Results:
A total of 102 nonfrail (63%) and 59 frail elderly (37%) patients, mean age of 70.8 (6.3) years were included. Most patients (54%; 72% nonfrail and 24% frail) recovered completely 1 to 3 years postinjury. Two weeks postinjury, 81% had posttraumatic complaints (83% frail and 80% nonfrail elderly), and 30% showed emotional distress (50% frail and 20% nonfrail). Frailty (odds ratio, 2.1; 95% confidence interval, 1.59-2.77) and presence of early complaints (odds ratio, 1.13; 95% confidence interval, 1.01-1.27) (Nagelkerke R
2 = 46%) were found to predict long-term outcome, whereas age was not a significant predictor.

Conclusion:
The frail elderly had worse long-term outcome, and early complaints were found to be a stronger predictor of unfavorable outcome than age. Understanding the implications of frailty on outcome could help clinicians recognize patients at risk of a poor outcome and allocate care more efficiently.
Cardiovascular Stress Reactivity and Carotid Intima-Media Thickness: The Buffering Role of Slow-Wave Sleep
Authors: Brindle Ryan C. , Duggan Katherine A. , Cribbet Matthew R. , Kline Christopher E. , Krafty Robert T. , Thayer Julian F. , Mulukutla Suresh R. , Hall Martica H. 
Published: January 2018

ABSTRACTObjectiveExaggerated cardiovascular reactivity to acute psychological stress has been associated with increased carotid intima-media thickness (IMT). However, interstudy variability in this relationship suggests the presence of moderating factors. The current study aimed to test the hypothesis that poor nocturnal sleep, defined as short total sleep time or low slow-wave sleep, would moderate the relationship between cardiovascular reactivity and IMT.MethodsParticipants (N= 99, 65.7% female, age = 59.3 ± 9.3 years) completed a two-night laboratory sleep study and cardiovascular examination where sleep and IMT were measured. The multisource interference task was used to induce acute psychological stress, while systolic and diastolic blood pressure and heart rate were monitored. Moderation was tested using the PROCESS framework in SPSS.ResultsSlow-wave sleep significantly moderated the relationship between all cardiovascular stress reactivity variables and IMT (allpinteraction≤ .048, all ΔR2interaction≥ .027). Greater stress reactivity was associated with higher IMT values in the low slow-wave sleep group and lower IMT values in the high slow-wave sleep group. No moderating effects of total sleep time were observed.ConclusionsThe results provide evidence that nocturnal slow-wave sleep moderates the relationship between cardiovascular stress reactivity and IMT and may buffer the effect of daytime stress-related disease processes.
Nickel–Titanium Wire as Suture Material: A New Technique for the Fixation of Skin
Authors: Li Haidong , Song Tao 
Published: January 2018

Purpose:
To introduce nickel–titanium wire as suture material for closure of incisions in cleft lip procedures.

Method:
Closure of skin incisions using nickel–titanium wire as suture material, with postoperative follow-up wound evaluation.

Results:
There was excellent patient satisfaction and good cosmetic outcome.

Conclusion:
Nickel–titanium wire is an excellent alternative for suture closure of cleft lip surgical incisions.
Trismus in Face Transplantation Following Ballistic Trauma
Authors: Krezdorn Nicco , Alhefzi Muayyad , Perry Bridget , Aycart Mario A. , Tasigiorgos Sotirios , Bueno Ericka M. , Green Jordan R. , Pribaz Julian J. , Pomahac Bohdan , Caterson Edward J. 
Published: January 2018

Background:
Trismus can be a challenging consequence of ballistic trauma to the face, and has rarely been described in the setting of face transplantation. Almost half of all current face transplant recipients in the world received transplantation to restore form and function after a ballistic injury. Here we report our experience and challenges with long standing trismus after face transplantation.

Methods:
We reviewed the medical records of our face transplant recipients whose indication was ballistic injury. We focused our review on trismus and assessed the pre-, peri- and postoperative planning, surgery and functional outcomes.

Results:
Two patients received partial face transplantation, including the midface for ballistic trauma. Both patients suffered from impaired mouth opening, speech intelligibility, and oral competence. Severe scarring of the temporomandibular joint (TMJ) required intraoperative release in both patients, and additional total condylectomy on the left side 6 months posttransplant for 1 patient. Posttransplant, both patients achieved an improvement in mouth opening; however, there was persistent trismus. One year after transplantation, range of motion of the jaw had improved for both patients. Independent oral food intake was possible 1 year after surgery, although spillage of liquids and mixed consistency solids persisted. Speech intelligibility testing showed impairments in the immediate postoperative period, with improvement to over 85% for both patients at 1 year posttransplant.

Conclusions:
Ballistic trauma to the face and subsequent reconstructive measures can cause significant scarring and covert injuries to structures such as the TMJ, resulting in long standing trismus. Meticulous individual planning prior to interventions such as face transplantation must take these into account. We encourage intraoperative evaluation of these structures as well as peri- and postoperative treatment when necessary. Due to the nature of the primary injury, functional outcomes after face transplantation in these patients may differ substantially from those of other indications.
Treatment of Mandibular Ameloblastoma Involving the Mandibular Condyle: Resection and Concomitant Reconstruction With a Custom Hybrid Total Joint Prosthesis and Iliac Bone Graft
Authors: Sarlabous Mathilde , Psutka David J. 
Published: January 2018

Aim:
To describe the treatment of ameloblastoma involving the mandibular body and condyle in 3 patients.

Methods:
This report describes 3 patients with large ameloblastomas (2 were second recurrences) treated by partial mandibular resection. Involvement of the mandibular condyle in these 3 patients made the reconstruction more challenging. Reconstruction included immediate temporomandibular joint replacement by a custom-made alloplastic total joint and mandibular body (Zimmer-Biomet, Jacksonville, FL). These devices were designed using virtual surgical planning software. The 3 patients underwent concomitant bone graft reconstruction using autogenous-free corticocancellous block bone grafts from the iliac crest. This facilitated later dental implant placement and full dental rehabilitation. Direct inferior alveolar nerve repair or nerve graft reconstruction with allograft was also carried out for all 3 patients. Maxillomandibular fixation was not used in all 3 patients.

Results:
All the 3 patients underwent successful surgery and recovery. Mandibular function was preserved. The concomitant bone graft allowed successful dental implant placement for subsequent planned restorative dentistry.

Conclusion:
Ameloblastoma involving the mandibular condyle can be successfully treated by resection and concomitant total joint replacement with an alloplastic device. This technique shows promise in that there is rapid return to excellent function thanks to rigid fixation of the construct. Mirroring software used in the prosthesis design facilitates excellent cosmetic outcomes.
The Current State of Surgical Ergonomics Education in U.S. Surgical Training
Authors: Epstein Sherise , Tran Bao N. , Capone Avery C. , Ruan Qing Z. , Fukudome Eugene Y. , Ricci Joseph A. , Testa Marcia A. , Dennerlein Jack T. , Lee Bernard T. , Singhal Dhruv 
Published: January 2018

Objective:
The aim of this study was to characterize the current state of surgical ergonomics education in the United States.

Background:
The burden of work-related musculoskeletal disorders (MSDs) in surgeons is high and no overarching strategy for redress exists. Twelve distinct specialties describe an unmet need for surgical ergonomics education (SEE). This study aimed to define the current state of SEE in U.S. surgical training programs.

Methods:
We performed a descriptive analysis of a 20-item questionnaire of ACGME-certified program directors from 14 surgical and interventional medical specialties. Formal SEE was defined as any organized education module that reviewed the occupation-specific burden of common work-related MSDs and described a framework for prevention via occupation-specific applied ergonomics. Program directors were queried regarding SEE provision, characteristics, and perceived trainee attitude toward the education.

Results:
Questionnaires were received from 130 of 441 (29.5%) program directors. Two (1.5%) provided formal SEE and 33 (25.4%) provided informal SEE, which consisted of unstructured intraoperative directives and isolated lectures. Two programs previously provided SEE but discontinued the effort due to lack of an evidence-based framework and instructors. Trainees appeared to think that learning surgical ergonomics skills was a worthwhile time investment in 100% and 76.7% of current formal and informal SEE, respectively.

Conclusion:
SEE is rarely provided in any capacity (25.4%), let alone in a consistent or evaluable fashion (1.5%). Impediments to sustainable SEE include lack of an evidence-based framework for education and instructors. An evidence-based, reproducible, and accreditation council-compliant SEE module would be a valuable resource for the surgical and interventional medical communities.