bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive rehabilitation and head injury
Authors: dos Santos Camila Batista , Figueiredo Eberval Gadelha , Teixeira Manoel Jacobsen 
Published: January 2018

AbstractThe present study aims to present the cognitive benefits and the importance of the use of compensatory strategies for a better functional adaptation and for the quality of life in patient that underwent cognitive rehabilitation (CR), after a severe cranioencephalic trauma. A 24 years-old male carried out neuropsychological evaluation after eight months of car accident. CR program developed for one year and four months, with constant establishment of goal, cognitive training and use of compensatory strategies for the difficulties in the daily tasks. It is possible to notice through the neuropsychological revaluation that the cognitive profits with the CR were global, including reaching expected performance for his age group in some functions. There was also observed, reach of great part of the stipulated goals, adaptation to the difficulties in the daily activities through the use of the strategies and consequently improves in the quality of life. This is a case that shows the contribution of the CR for patients who suffered CET, even after the process of spontaneous recuperation, in a moment that, from the clinical point of view, constant sequels keeps in mind.
Percepção da qualidade de vida no trabalho dos neurocirurgiões em São Paulo
Authors: da Silva Sandra Arcelina , Guerreiro Ramon Barbalho , Fernandes Audi Marise Augusto , Audi Fernanda Fernandes , Buscariolli Yuri dos Santos , Rotta José Marcus , Botelho Ricardo Vieira 
Published: January 2018

Resumo
Contexto: Estudos da percepção da qualidade de vida no trabalho (QVT) permitem estimar a percepção de uma classe profissional inteira, identificar desequilíbrios específicos e proporcionar políticas de desenvolvimento profissional. Objetivo: Avaliar a percepção da QVT dos neurocirurgiões que trabalham em Serviços de Emergência em São Paulo usando instrumentos de validação disponíveis na língua portuguesa. Método: A percepção da QVT dos neurocirurgiões da cidade de São Paulo (Capital) foi estudada com questionário validado para língua portuguesa. Resultados: Cinquenta e oito neurocirurgiões responderam ao questionário. A análise revelou fortes tendências negativas na maioria das áreas de QVT. As áreas com forte tendência negativa deveriam ser tratadas com políticas específicas. Conclusão: Há fortes tendências negativas em quase todos os domínios da QVT.
Concordância entre diagnósticos neuropatológicos premortem e postmortem em 90 pacientes com síndrome da imunodeficiência adquirida, submetidos à necrópsia em um hospital de ensino no Brasil
Authors: Lemos da Silva Ana Cristina Araújo , Carli Rodrigues Blenda Sousa , Melo Moura Everton Nunes de , de Meneses Antonio Carlos Oliveira , Rua Micheletti Adilha Misson , Silva Vergara Mario Leon , Adad Sheila Jorge 
Published: January 2018

Resumo
Objetivo: Estudar as lesões anatomopatológicas no SNC, analisando se contribuíram para o óbito desses pacientes e avaliar a concordância entre os diagnósticos neuropatológicos premortem e postmortem. Método: Estudo retrospectivo com análise de 90 necrópsias sequenciais de SIDA, realizadas entre 1989 e 1996, além de busca de dados epidemiológicos/clínicos e comparação com a suspeita clínica para avaliar concordância entre diagnóstico pre e postmortem. Resultados: Idade média 34 ± 11 anos; 81,1% do sexo masculino; todos apresentavam alguma alteração no SNC, sendo relevantes para o óbito em 54 (60%) casos. Apenas em 15 (27,8%) desses 54 casos houve suspeita clínica da lesão. As lesões encontradas no SNC foram: toxoplasmose (34,4%), criptococose (12,2%), citomegalovirose (4,4%), encefalite nodular microglial (3,3%), meningite bacteriana (2,2%), infecção pelo vírus JC (2,2%), tuberculose/micobacteriose (2,2%), histoplasmose (1,1%) e paracoccidioidomicose (1,1%). As alterações não relacionadas ao óbito (40%) foram: gliose, fibrose meníngea focal, infarto antigo, calcificações e edema. Conclusão: Este estudo confirma que existem diversas alterações no SNC de pacientes com SIDA, sobretudo infecções oportunistas, frequentemente não suspeitadas clinicamente, evidenciando a importância da necrópsia. Esses achados sugerem que investigação minuciosa deveria ser feita no SNC de pacientes com SIDA, particularmente naqueles com diagnóstico tardio ou que não estão respondendo ao tratamento.
Aeschylus’s Oresteia
Authors: Mitchell-Boyask Robin 
Published: January 2018

The Oresteia, the pinnacle, and likely the final production, of Aeschylus’s long career in Athens, was produced at the City Dionysia of 458 bce, where it won the first prize. The Oresteian tetralogy consisted of four plays—Agamemnon, Libation Bearers (Choephori), Eumenides, and the satyr-play, Proteus, which was lost—with the first three plays forming the only trilogy to survive antiquity. Since Aeschylus died in Sicily two years later and there is no evidence of any Athenian productions in the intervening period, Aeschylus likely ended his career victoriously at the City Dionysia with the Oresteia. The theme of the Oresteia, justice, was a particularly urgent concern for a democracy that was still only a half-century old. To address this theme Aeschylus transformed from the Odyssey the myth of the final phases of the House of Atreus: the murder of Agamemnon by his wife Clytemnestra and cousin Aegisthus after the sack of Troy, and the consequent matricide committed by their son Orestes. Aeschylus, to maximize the dramatic potential of his theme, re-imagined the myth so that the system of justice as vendetta reaches an absolute crisis in the form of an intra-familial gender war that takes on a cosmic scale that results in the origins of the legal system wherein humans are held accountable for their actions and tried by other humans who are not party to those actions. In addressing justice through the origin of the Areopagus tribunal, Aeschylus, uncharacteristically for Greek tragedy, engaged one of the most explosive political issues of this time, since, a few years earlier, Ephialtes, attempting to check the power of aristocratic institutions like the Areopagus, stripped it of its broader powers, but was assassinated shortly after the changes were instituted. The Oresteia also participated in major changes to Athenian dramaturgy, as Aeschylus used—possibly for the first time—the skēnē building, the wheeled cart (ekkyklêma), and a third actor.
Adoption of Minimally Invasive Surgery and Decrease in Surgical Morbidity for Endometrial Cancer Treatment in the United States
Authors: Casarin Jvan , Multinu Francesco , Ubl Daniel S. , Dowdy Sean C. , Cliby William A. , Glaser Gretchen E. , Butler Kristina A. , Ghezzi Fabio , Habermann Elizabeth B. , Mariani Andrea 
Published: January 2018

OBJECTIVE:
To assess how the widespread adoption of minimally invasive surgery in the United States is associated with changes in 30-day morbidity and mortality in endometrial cancer treatment.

METHODS:
In this retrospective cohort study, the American College of Surgeons’ National Surgical Quality Improvement Project database for 2008–2014 was reviewed for patients who had undergone surgery for endometrial cancer according to their primary Current Procedural Terminology (CPT) codes. Women with CPT codes for advanced cancer or with disseminated disease were excluded. A trend analysis across the time period by surgical approach (open surgery through laparotomy, vaginal surgery, and minimally invasive surgery) was performed using a Cochran-Armitage test for trend. Thirty-day surgical outcomes were compared between patients who had minimally invasive surgery and open surgery. Inverse probability of treatment weighting models were used to investigate the independent effect of minimally invasive surgery on 30-day outcomes.

RESULTS:
Overall, 12,283 patients met the inclusion criteria. A significant implementation of minimally invasive surgery (24.2–71.4%) and a concomitant decrease in open surgery through laparotomy (71.1–26.4%) were observed from 2008 to 2014 (both P<.001). Rate of vaginal surgery did not change over time (1.5–2.2%, P=.06). After adjusting for possible confounders, open surgery (compared with minimally invasive surgery) was independently associated with increased odds of major complications (n=347 versus n=274, adjusted odds ratio [OR] 2.4, 95% CI 2.0–2.8), readmission (n=269 versus n=238, adjusted OR 2.2, 95% CI 1.8–2.6), reoperation (n=80 versus n=93, adjusted OR 1.5, 95% CI 1.2–2.1), superficial surgical site infection (n=190 versus n=55, adjusted OR 6.8, 95% CI 5.0–9.2), perioperative transfusion (n=430 versus n=149, adjusted OR 5.9, 95% CI 4.8–7.1), and death (n=41 vs, n=20, adjusted OR 3.8, 95% CI 2.2–6.6). A comprehensive decrease in 30-day morbidity for the treatment of endometrial cancer overall was observed from 2008 to 2014 (P<.001), whereas 30-day mortality remained stable (P=.24).

CONCLUSION:
The widespread adoption of minimally invasive surgery is associated with substantial decreases in 30-day morbidity, readmission, and reoperation for women treated for endometrial cancer in the United States.
Obstetric Outcomes After Failed Hysteroscopic and Laparoscopic Sterilization Procedures
Authors: Brandi Kristyn , Morgan Jake R. , Paasche-Orlow Michael K. , Perkins Rebecca B. , White Katharine O'Connell 
Published: January 2018

OBJECTIVE:
To compare obstetric outcomes after failed hysteroscopic and laparoscopic sterilization.

METHODS:
This retrospective cohort study examined pregnancy outcomes including live birth, preterm birth, stillbirth, spontaneous abortion, therapeutic abortion, ectopic pregnancies, and gestational trophoblastic disease using a commercial claims administrative database for the years 2007–2013. We used a Z-test to compare pregnancy outcomes per 100 person-years based on type of sterilization. Cox proportional hazard models controlled for patient age, geographic region, urbanicity, comorbidities, and insurance type.

RESULTS:
We evaluated 997 pregnancy outcomes among 817 women from a total of 70,115 women with a history of either hysteroscopic sterilization (n=387 pregnancies/27,724 cases) or laparoscopic sterilization (n=610 pregnancies/42,391 cases). Women undergoing hysteroscopic sterilization were slightly older than, but otherwise similar to, women undergoing laparoscopic sterilization. The most common outcome was live birth, which was more likely after hysteroscopic sterilization compared with laparoscopic sterilization (adjusted hazard ratio 1.32, 95% CI 1.09–1.60). The rate of spontaneous abortion was not statistically significantly different between the two groups. Therapeutic abortion occurred more often after hysteroscopic sterilization (adjusted hazard ratio 1.49, 95% CI 1.10–2.01), whereas ectopic pregnancies occurred less often (adjusted hazard ratio 0.12, 95% CI 0.05–0.29) compared with laparoscopic sterilization.

CONCLUSION:
Hysteroscopic sterilization is associated with higher rates of live birth and lower rates of ectopic pregnancy compared with laparoscopic sterilization. Spontaneous abortion and preterm birth rates were similar in both groups. These data do not support an adverse effect of hysteroscopic sterilization on subsequent pregnancy outcomes.
VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY
Authors: Gabr Hesham , Chen Xi , Zevallos-Carrasco Oscar M. , Viehland Christian , Dandrige Alexandria , Sarin Neeru , Mahmoud Tamer H. , Vajzovic Lejla , Izatt Joseph A. , Toth Cynthia A. 
Published: January 2018

Purpose:
To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications.

Methods:
In this prospective study, we analyzed a subgroup of patients with proliferative diabetic retinopathy complications who required vitrectomy and who were imaged by the research swept-source microscope-integrated optical coherence tomography system. In near real time, images were displayed in stereo heads-up display facilitating intraoperative surgeon feedback. Postoperative review included scoring image quality, identifying different diabetic retinopathy-associated pathologies and reviewing the intraoperatively documented surgeon feedback.

Results:
Twenty eyes were included. Indications for vitrectomy were tractional retinal detachment (16 eyes), combined tractional-rhegmatogenous retinal detachment (2 eyes), and vitreous hemorrhage (2 eyes). Useful, good-quality 2D (B-scans) and 4D images were obtained in 16/20 eyes (80%). In these eyes, multiple diabetic retinopathy complications could be imaged. Swept-source microscope-integrated optical coherence tomography provided surgical guidance, e.g., in identifying dissection planes under fibrovascular membranes, and in determining residual membranes and traction that would benefit from additional peeling. In 4/20 eyes (20%), acceptable images were captured, but they were not useful due to high tractional retinal detachment elevation which was challenging for imaging.

Conclusion:
Swept-source microscope-integrated optical coherence tomography can provide important guidance during surgery for proliferative diabetic retinopathy complications through intraoperative identification of different complications and facilitation of intraoperative decision making.
Obstructive Sleep Apnea Assessed by Overnight Polysomnography in Patients With Keratoconus
Authors: Pedrotti Emilio , Demasi Christian Luigi , Fasolo Adriano , Bonacci Erika , Brighenti Tommaso , Gennaro Nicola , Ferrari Marcello , Marchini Giorgio 
Published: January 2018

Purpose:
To determine the prevalence of obstructive sleep apnea (OSA) in patients with keratoconus (KCN) and to evaluate the association between the severity of KCN and OSA.

Methods:
OSA was diagnosed with an overnight home sleep apnea test. As estimated by home monitoring, an apnea–hypopnea index threshold of ≥5 sleep-related obstructive breathing events per hour was considered suggestive of OSA. For grading KCN severity (Amsler–Krumeich classification), slit-lamp biomicroscopy, corneal topography, and pachymetry measurements were performed. Preoperative measurements were included in the analysis for patients who had undergone surgery for KCN.

Results:
The study sample consisted of 50 consecutively enrolled patients: 33 men; mean age ± SD 43.6 ± 11.8 years; body mass index 29.7 ± 7.3 kg/m2; and neck circumference 40.0 ± 3.4 cm. The overall prevalence of OSA was 38% (6 women and 13 men). Patients with OSA were older (49.8 ± 9.3 vs. 37.5 ± 10.8 years; P < 0.01) and had a higher body mass index (34.7 ± 8.1 vs. 26.2 ± 4.8 kg/m2; P <0.01), neck circumference (41.2 ± 2.6 vs. 38.7 ± 3.6 cm; P < 0.01), and cylinder diopter (5.98 ± 1.94 vs. 4.05 ± 3.55 D; P = 0.045) compared with those without OSA. No significant association was found between OSA severity and ocular parameters and KCN grade.

Conclusions:
As measured by overnight home sleep apnea testing, OSA was 10 to 20 times more prevalent among patients with KCN than the rate reported for the general population. The rate lies between the prevalence estimated from sleep study data of self-reported diagnosis of OSA and the risk of developing OSA as determined by the Berlin Questionnaire.
Susceptibility of Neisseria gonorrhoeae to Gentamicin—Gonococcal Isolate Surveillance Project, 2015–2016
Authors: Mann Laura M. , Kirkcaldy Robert D. , Papp John R. , Torrone Elizabeth A. 
Published: January 2018

Abstract
The gentamicin minimum inhibitory concentrations (MICs) of Neisseria gonorrhoeae isolates were determined. Seventy-three percent of isolates demonstrated an MIC range of 8 to 16 μg/mL, and 27% demonstrated an MIC of 4 μg/mL or less. Significant associations between gentamicin MIC and resistance or reduced susceptibility to other antimicrobials were found.
Guidance on filtering DNA methylation microarray probes by detection p-values
Authors: Heiss Jonathan A. , Just Allan C. 
Published: January 2018

AbstractDNA methylation microarrays are popular for epigenome-wide association studies, but spurious outlier values complicate downstream analysis. It was demonstrated previously that commonly used detection p-value cut-offs were insufficient and led to many calls on the Y-chromosome probes in females. We extend these observations by assessing 2,578 samples from 18 studies run on the 450K chip as well as outliers across technical replicates. We provide comprehensive guidance and software for filtering methylation microarrays as an essential step to reduce outliers.
The Impact of fodder onBombyx Mori
Authors: Flores Victor , Medina Katherine 
Published: January 2018

AbstractSilk production by the Chilean silkworm, although an important source of revenue, has not been extensively studied. In the current study, we research 564 Mountain Silkworm (Bombyx mori), analyzing their silk harvests, silk production incubation periods and demographic profiles. The mountain silkworms were randomly divided into two clusters (cluster#1, cluster#2), each of which had 56 mountain silkworms. Crumpled maize were replaced by steam-flaked maize 30%, 50%, 100%, then researched the effects of nourishing steam-flaked maize on production performance of silk production by silkworm. The outcomes showed that the cluster#2 had better median silk harvest than cluster#1, the mean of these increment silk harvests was 3.48pounds (P-value <0.05); the protein proportion and the sugar in silk of cluster#2 went up than cluster#1; for the urine nitrogen and somatic cell count of cluster#2 were lower than cluster#1 by 0.9% (P-value >0.05), 30,800 cells/ml (P-value<0.05), respectively. The current research confirmed that utilizing the JHO nutrition heightened silk harvest, improved silk production characteristics, and enhanced the performance of mountain silkworms; furthermore, it heightened resistance to the sickness due to strengthened resistance.
Exploring protein orthogonality in immune space: a case study with AAV and Cas9 orthologs
Authors: Moreno Ana M. , Palmer Nathan , Alemán Fernando , Chen Genghao , Pla Andrew , Chew Wei Leong , Law Mansun , Mali Prashant 
Published: January 2018

ABSTRACTA major hurdle in protein-based therapeutics is the interaction with the adaptive immune system, which can lead to neutralization by circulating antibodies and clearance of treated cells by cytotoxic T-lymphocytes. One method of circumventing these issues is to use human or humanized proteins which avoid the immune response by self-recognition. However, this approach limits potential protein therapeutics to those of human origin, excluding many exciting effectors and delivery vehicles such as CRISPR-Cas9 and adeno-associated viruses (AAVs). To address this issue, we propose here the sequential use of orthologous proteins whose function is constrained by natural selection, but whose structure is subject to diversification by genetic drift. This would, in principle, allow for repeated treatments by ‘immune orthogonal’ orthologs without reduced efficacy due to lack of immune cross-reactivity among the proteins. To explore and validate this concept we chose 91 Type II CRISPR-Cas9 orthologs and 167 AAV capsid protein orthologs, and developed a pipeline to compare total sequence similarity as well as predicted binding to class I and class II Major Histocompatibility Complex (MHC) proteins. Interestingly, MHC binding predictions revealed wide diversity among the set of Cas9 orthologs, with 83% of pairs predicted to have non cross-reacting immune responses, while no global immune orthogonality among AAV serotypes was observed. To confirm these findings we selected two Cas9 orthologs, fromS. pyogenesandS. aureus, predicted to be orthogonal in immune space, and delivered them into mice via multiple AAV serotypes. We observed cross-reacting antibodies against AAV but not Cas9 orthologs in sera from immunized mice, validating the computationally predicted immune orthogonality among these proteins. Moving forward, we anticipate this framework can be applied to prescribe sequential regimens of immune orthogonal protein therapeutics to circumvent pre-existing or induced immunity, and eventually, to rationally engineer immune orthogonality among protein orthologs.
216 GHz Electron Paramagnetic Resonance of Mycobacterium Tuberculosis Catalase-Peroxidase: The Role of the Arg418 Residue
Authors: Bawn Matt , Krzystek Jurek , Magliozzo Richard 
Published: January 2018

ABSTRACTThe catalase-peroxidase protein from Mycobacterium tuberculosis contains a variety of unique structural features including a covalently-linked three amino acid adduct capable of hosting a tyrosine-based radical. Previous work has demonstrated that the Arg418 residue is essential for the catalse but not the peroxidase activity of the protein and crystallography has indicated the residue to be capable of adopting two conformations relative to the adduct-radical. In the present work the WT and Arg418Leu mutant proteins were investigated using high-field electron magnetic resonance spectroscopy. Different sets of g-values were found for each protein indicating different paramagnetic environments. Quantum chemical calculations of model structures were undertaken to elucidate the geometrical environment of the radical. It is proposed that the two sets of g-values correspond to the two conformations of the Arg418 residue. The implications for the catalytic mechanism are discussed.
Attractiveness of discount rate versus limited quantity
Authors: Park Hye Kyung , Shin Bong-Sup , Huh Jong-Ho 
Published: January 2018

Purpose
This paper aims to examine how the temporal distance can influence the effect of the scarcity message. To demonstrate this effect, the authors use the limited-quantity flash sales and compare two types of mixed promotion method comprising discount rate and limited quantity.

Design/methodology/approach
The results of the experiment reveal that consumers in the temporally distant condition have a relatively high-level construal of the limited-quantity flash sales and are more likely to value desirability (discount rate) over feasibility (limited quantity).

Findings
When the expected value is identical, consumers prefer limited-quantity flash sales with smaller limited quantity but higher discount rates. However, consumers in the temporally near condition have a relatively low-level construal of the limited-quantity flash sales and are more likely to value feasibility (limited quantity) over desirability (discount rate).

Originality/value
When the expected value is identical, consumers prefer limited-quantity flash sales with lower discount rates but larger limited quantity.