bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of protective atmosphere on decarburisation of the heat-treated surface of steel
Authors: Tonkovič Marica Prijanovič , Knez Miha 
Published: January 2018

Abstract
In heat-treating furnaces, many different types of protective atmospheres are used. This article researches the effect of protective atmospheres on the quality of the surface layer of bolts during the process of heating to reach the temperature of hardening. For this research, we produced specimens that were annealed in the furnace with two different types of protective atmosphere, i.e. in atmospheres of endothermic gas and nitrogen. After hardening and tempering, we measured the hardness of the specimens and investigated the microstructure. We measured the hardness profile from the surface to the inside of the product. We found that the hardness of the surface of the tested product was lower while using protective atmosphere of nitrogen due to the occurrence of ferrite. The depth of the decarburised layer in this atmosphere reached up to 70 mm, where predominantly there was a microstructure of ferrite on the surface, and then, with depth, an increasingly mixed microstructure of ferrite and martensite was found. The depth of the decarburised layer for sample treated in endothermic gas was minimal (i.e. 10 mm) on the surface.
Organization and Planning of Corporate Education in the Czech Republic
Authors: Caha Zdeněk 
Published: January 2018

Abstract
The aim of this paper was to determine by means of a questionnaire survey to what extent large and medium-sized companies in the Czech Republic apply a systematic approach to education. This is, amongst other things, dependent on the existence of long-term and annual education plans and on whether the education is organized systematically by a personnel department or by a dedicated staff department focused on education. Two hypotheses were set. The first, that in at least 70 % of large companies and 50 % of medium-sized company education is organized by a personnel department or a separate staff department focused on education. The second, that at least 70 % of large companies and 50 % of medium-sized companies have a long-term education plan, including an annual education plan, in place. Although neither of the hypotheses were confirmed, it was proven that large companies approach the issue of corporate education in a more systematic way than medium-sized ones.
Indication of Changes in Projecting Organizational Structures Under the New Economy
Authors: Pártlová Petra 
Published: January 2018

Abstract
Enterprise Architecture includes organizational and management part and visions and goals of the organization, business processes leading to the goals, innovation processes, control mechanisms, information and communication technologies and others. The paper focuses on one of the most important components of corporate architecture, organizational and management framework of an enterprise in terms of its present state and anticipated changes and the expected development in the context of the emerging new economy. The research was carried out in a sample of 372 enterprises from the whole Czech Republic with the sector (industrial, manufacturing, services and primary sector) and size differentiation (micro-enterprises, small and medium-sized enterprises and large enterprises according to the classification of Ministry of Industry and Trade of the Czech Republic and the EU). The statistical methods were used (p-value with Pearson Chi quadrate output) to analyses the results. The conclusion indicates a possible development in the corporate organization architecture in the context of the paradigm of changes in the external corporate environment.
Analyzing the management process in small and medium-sized enterprises in the Region of South Bohemia
Authors: Váchal Jan , Jambal Tsolmon 
Published: January 2018

Abstract
The entry is aimed at analyzing the process of managing small and medium-sized enterprise, specifically in the Region of South Bohemia. The testing sample included 180 enterprises. The fundamental statistical information about SMEs is included, focusing of the numbers, the size category, and their specialization in the Region of South Bohemia. The research activities were aimed at the steepness of management structures and at their extent on all management levels. The analysis indicates that micro-enterprises prefer one management level, while small and middle-sized enterprises prefer two management levels with the statistic dependence on the size category. In regard to the number of employees on individual management levels, the top positions have from 6 employees up to 30 on the operative level. The general business trend involves a transfer to the functional management structure. With respect to the strategic management and decision- making, enterprises boost an attractive prospect of mainly their own sources. A statistical correlation was proved between the elaborated strategy, the size of the enterprise and number of management levels. A strong correlation between the number of management levels and the aim of the enterprise i.e. the type of organization structure was not proved.
Composition, Mixing State and Water Affinity of Meteoric Smoke Analogue Nanoparticles Produced in a Non-Thermal Microwave Plasma Source
Authors: Nachbar Mario , Duft Denis , Kiselev Alexei , Leisner Thomas 
Published: January 2018

Abstract
The article reports on the composition, mixing state and water affinity of iron silicate particles which were produced in a non-thermal low-pressure microwave plasma reactor. The particles are intended to be used as meteoric smoke particle analogues. We used the organometallic precursors ferrocene (Fe(C5H5)2) and tetraethyl orthosilicate (TEOS, Si(OC2H5)4) in various mixing ratios to produce nanoparticles with radii between 1 nm and 4 nm. The nanoparticles were deposited on sample grids and their stoichiometric composition was analyzed in an electron microscope using energy dispersive X-ray spectroscopy (EDS). We show that the pure silicon oxide and iron oxide particles consist of SiO2 and Fe2O3, respectively. For Fe:(Fe+Si) ratios between 0.2 and 0.8 our reactor produces (in contrast to other particle sources) mixed iron silicates with a stoichiometric composition according to FexSi(1−x)O3 (0≤x≤1). This indicates that the particles are formed by polymerization of FeO3 and SiO3 and that rearrangement to the more stable silicates ferrosilite (FeSiO3) and fayalite (Fe2SiO4) does not occur at these conditions. To investigate the internal mixing state of the particles, the H2O surface desorption energy of the particles was measured. We found that the nanoparticles are internally mixed and that differential coating resulting in a core-shell structure does not occur.
Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference
Authors: Wayman Wesley N. , Woodward John J. 
Published: January 2018

Abuse rates for inhalants among adolescents continue to be high, yet preclinical models for studying mechanisms underlying inhalant abuse remain limited. Our laboratory has previously shown that, in male rats, an acute binge-like exposure to toluene vapor that mimics human solvent abuse modifies the intrinsic excitability of mPFC pyramidal neurons projecting to the NAc. These changes showed region (infralimbic; IL vs prelimbic; PRL), layer (shallow; 2/3 vs deep; 5/6), target (core vs shell), and age (adolescent vs adult) dependent differences (Wayman and Woodward, 2017). To expand these findings using reward-based models that may better mimic human drug abuse, we used whole-cell electrophysiology and drug receptors exclusively activated by designer drugs to examine changes in neuronal function and behavior in rats showing a conditioned place preference (CPP) to toluene. Repeated pairings of adolescent rats to binge concentrations of toluene vapor previously shown to enhance dopamine release in reward-sensitive areas of the brain produced CPP that persisted for 7 but not 30 d. Toluene-induced CPP was associated with increased excitability of IL5/6 mPFC neurons projecting to the core of the NAc and reduced excitability of those projecting to the NAc shell. No changes in PRL-NAc-projecting neurons were found in toluene-CPP rats. Chemogenetic reversal of the toluene-induced decrease in IL5/6-NAc shell neurons blocked the expression of toluene-induced CPP while manipulating IL5/6-NAc core neuron activity had no effect. These data reveal that alterations in selective mPFC-NAc pathways are required for expression of toluene-induced CPP.SIGNIFICANCE STATEMENTDisturbed physiology of pyramidal neurons projecting from the mPFC to the NAc has been shown to have different roles in drug-seeking behaviors for a number of drugs (e.g., methamphetamine, cocaine, ecstasy, alcohol, heroin). Here, we report that rats repeatedly exposed to the volatile organic solvent toluene, a member of the class of abused inhalants often used for intoxicating purposes by adolescents, induces a preference for the drug-paired environment that is accompanied by altered physiology of a specific population of NAc-projecting mPFC neurons. Chemogenetic correction of this deficit before testing prevented expression of drug preference. Overall, these findings highlight the importance of corticolimbic circuitry in mediating the rewarding properties of abused inhalants.
Bendamustine plus Rituximab Versus R-CHOP as First-Line Treatment for Patients with Follicular Lymphoma Grade 3A: Evidence from a Multicenter, Retrospective Study
Authors: Mondello Patrizia , Steiner Normann , Willenbacher Wolfgang , Cerchione Claudio , Nappi Davide , Mauro Endri , Ferrero Simone , Cuzzocrea Salvatore , Mian Michael 
Published: January 2018

Abstract

Background
Rituximab plus bendamustine (R-B) has been demonstrated to improve outcomes and reduce toxicity compared with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHOP) in follicular lymphoma (FL). Nevertheless, in clinical practice, many centers still prefer R-CHOP to R-B in patients with FL grade 3A (FL3A). Therefore, we retrospectively assessed patients with FL3A treated with either R-CHOP or R-B in five European cancer centers and compared their outcomes.

Materials and Methods
We retrospectively assessed 132 patients affected by FL grade 3A treated with either R-B or R-CHOP in the first line and evaluated outcome and toxicity according to the type of treatment. This study included 101 patients who were a subgroup of a previously published cohort.

Results
R-B was less toxic and achieved a similar percentage of complete remissions compared with R-CHOP (97% vs. 96%, p = .3). During follow-up, 10 (16%) patients relapsed after R-B and 29 (41%) after R-CHOP (p = .001), leading to a median progression-free survival (PFS) of 15 versus 11.7 years, respectively (p = .03). Furthermore, R-B overcame the negative prognostic impact of BCL2 expression (15 vs. 4.8 years; p = .001). However, median overall survival was similar between both groups (not reached for both; p = .8).

Conclusion
R-B as a first-line treatment of FL3A is better tolerated than R-CHOP and seems to induce more profound responses, leading to a significantly lower relapse rate and prolonged PFS. Therefore, R-B is a valid treatment option for FL grade 3A.

Implications for Practice
Rituximab plus bendamustine (R-B) has shown to be less toxic and more effective than rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHOP) in follicular lymphoma grade 3A. Although both regimens can induce a complete remission in &gt;95% of patients, relapses occur more frequently after R-CHOP than R-B, leading to a significantly longer progression-free survival in the latter. R-B is also able to overcome the impact of negative prognosticators, such as BCL2 expression. However, because of the indolent course of this disease and efficient salvage treatments, overall survival was similar in both treatment groups. Therefore, R-B is a valid treatment option in this patient setting.
Characteristics of Real-World Metastatic Non-Small Cell Lung Cancer Patients Treated with Nivolumab and Pembrolizumab During the Year Following Approval
Authors: Khozin Sean , Abernethy Amy P. , Nussbaum Nathan C. , Zhi Jizu , Curtis Melissa D. , Tucker Melisa , Lee Shannon E. , Light David E. , Gossai Anala , Sorg Rachael A. , Torres Aracelis Z. , Patel Payal , Blumenthal Gideon Michael , Pazdur Richard 
Published: January 2018

Abstract

Background
Evidence from cancer clinical trials can be difficult to generalize to real-world patient populations, but can be complemented by real-world evidence to optimize personalization of care. Further, real-world usage patterns of programmed cell death protein 1 (PD-1) inhibitors following approval can inform future studies of subpopulations underrepresented in clinical trials.

Materials and Methods
We performed a multicenter analysis using electronic health record data collected during routine care of patients treated in community cancer care clinics in the Flatiron Health network. Real-world metastatic non-small cell lung cancer (NSCLC) patients who received nivolumab or pembrolizumab in the metastatic setting (n = 1,344) were selected from a starting random sample of 55,969 NSCLC patients with two or more documented visits from January 1, 2011, through March 31, 2016. The primary study outcome measurement was demographic and treatment characteristics of the cohort.

Results
Median age at PD-1 inhibitor initiation was 69 years (interquartile range 61–75). Patients were 56% male, 88% smokers, 65% nonsquamous histology, and 64% diagnosed at stage IV. Of 1,344 patients, 112 (8%) were tested for programmed death-ligand 1 expression. Overall, 50% received nivolumab or pembrolizumab in the second line, with a substantial proportion of third and later line use that began to decline in Q4 2015.

Conclusion
During the year following U.S. regulatory approval of PD-1 inhibitors for treatment of NSCLC, real-world patients receiving nivolumab or pembrolizumab were older at treatment initiation and more had smoking history relative to clinical trial cohorts. Studies of outcomes in underrepresented subgroups are needed to inform real-world treatment decisions.

Implications for Practice
Evidence gathered in conventional clinical trials used to assess safety and efficacy of new therapies is not necessarily generalizable to real-world patients receiving these drugs following regulatory approval. Real-world evidence derived from electronic health record data can yield complementary evidence to enable optimal clinical decisions. Examined here is a cohort of programmed cell death protein 1 inhibitor-treated metastatic non-small cell lung cancer patients in the first year following regulatory approval of these therapies in this indication. The analysis revealed how the real-world cohort differed from the clinical trial cohorts, which will inform which patients are underrepresented and warrant additional studies.
ISLAM NUSANTARA: SEBUAH ARGUMENTASI BERAGAMA DALAM BINGKAI KULTURAL
Authors: Astuti Hanum Jazimah Puji 
Published: January 2018

AbstractThe emergence of Islam Nusantara is the typical of Indonesia, where Islam Nusantara is declared as a universal religion, manifested in its teachings including religious law (fiqh), trust (faith), and the ethical (the moral). Although Islam Nusantara gives a new ambience in Islam by assimilating a culture into religion, this method is not contagious to the purity of Islamic teachings by taking Quran and Hadith as the guidances and directions in the Indonesian social life. Islam teaches mutual respect and reciprocal tolerance. This religion teaches the adherents to love others, to mercy and nurture regardless of race, nationality, and social structure. This is in line with the Indonesian Islam commonly called ‘Islam Nusantara’. It can be said that someone who lived in the religion, including people that comprehend the religion intrinsically, occupies religion as a guide of life, applies and practices based on the belief. At the social level, religious values serve as the basis for adopting a life policy. AbstrakPemunculan Islam Nusantara merupakan ciri khas Indonesia, di mana Islam Nusantara ini di nyatakan sebagai agama yang universal, dimanifestasikan dalam ajarannya, yang mencakup hukum agama (fiqh), kepercayaan (tauhid), serta etika (akhlak). Meskipun Islam Nusantara memberikan nuansa baru dalam beragama Islam dengan memasukkan budaya dalam agamanya, namun cara beragama seperti ini tidak menghilangkan kemurnian ajaran Islam itu sendiri, dengan menjadikan al Quran dan Hadits sebagai pedoman dan tuntunan dalam kehidupan sosial masyarakat Indonesia. Dalam beragama, Islam mengajarkan untuk saling menghargai dan saling toleransi, agama yang mengajarkan penganutnya untuk saling menyayangi, mengasihi dan mengayomi tanpa me mandang ras, kebangsaan, serta struktur sosial. Hal ini sejalan dengan Islamnya Indonesia yang biasa disebut ‘Islam Nusantara’. Dapat dikatakan seseorang yang menjalani agama itu, termasuk orang yang menghayati agamanya dengan cara intrinsik, agama dijadikan sebagai pedoman hidup, dijalankan dan diamalkan sesuai dengan keyakinannya. Pada tataran sosial nilai-nilai agama dijadikan sebagai dasar dalam mengambil kebijakan hidup.
Growth performance of African catfish Clarias gariepinus cultured in biofloc system at high stocking density
Authors: Soedibya Petrus Hary Tjahja , Pramono Taufik Budhi , Listiowati Emyliana 
Published: January 2018

ABSTRACT This study was aimed to analyze the growth performance of African catfish Clarias gariepinus cultured in the biofloc system at high stocking density. African catfish with an average weight of 1.85±0.09 g were cultured in four units of tarpaulin tank at a diameter of 1.72 m and a height of 1.05 m with a volume of ±2,000 L at the different density of 1,000 fish/m3; 1,500 fish/m3; 2,000 fish/m3; 2,500 fish/m3. During rearing period, fish were given the artificial feed with protein contents of 28.75% with the frequency of twice a day, as much as 3% of the body weight. The results showed that different treatment of high stocking density in the biofloc system had a significant effect on the absolute growth rate, lipid retention and energy retention (P<0.05) but not significant effect on daily growth rate. The results showed that the highest lipid retention and energy retention were found in the group of fish treated at a stocking density of 2,500 fish/m3 but declining protein retention and growth in fish occurred. The highest absolute growth rate and daily growth rate were shown by treatment with a stocking density of 1,500 fish/m3. Keywords: growth, stocking density, biofloc ABSTRAK Penelitian ini bertujuan untuk menganalisis performa pertumbuhan ikan lele dumbo Clarias gariepinus yang dipelihara pada sistem bioflok dengan padat penebaran tinggi. Ikan uji memiliki berat rata-rata 1,85±0,09 g yang dipelihara pada kolam terpolin berdiameter 1,72 m dan tinggi 1,05 m dengan volume air ±2.000 L sebanyak empat unit dengan kepadatan yang berbeda yaitu 1.000 ekor/m3, 1.500 ekor/m3, 2.000 ekor/m3, 2.500 ekor/m3. Selama 40 hari masa pemeliharaan, ikan diberi pakan buatan berkadar protein 28,75% dengan frekwensi dua kali sehari, sebanyak 3% dari berat tubuh. Hasil penelitian menunjukkan bahwa perlakuan perbedaan padat penebaran tinggi pada sistem bioflok memberikan pengaruh yang nyata terhadap pertumbuhan mutlak, retensi lemak dan retensi energi (P<0,05) namun tidak memberikan pengaruh nyata terhadap laju pertmbuhan harian. Hasil penelitian menunjukkan bahwa semakin tinggi padat penebaran terjadinya peningkatan retensi lemak dan retensi energi yaitu pada perlakuan padat penebaran 2.500 ekor/m3 tetapi terjadi penurunan nilai retensi protein dan pertumbuhan pada ikan. Nilai pertumbuhan mutlak tertinggi ditunjukkan oleh perlakuan dengan padat penebaran 1.500 ekor/m3. Kata kunci: pertumbuhan, padat tebar, bioflok
Factores Asociados a Hemorragia Intraventricular En Neonatos Atendidos En Un Hospital de Segundo Nivel
Authors: Camacho Miguel Ángel Martínez , Lira Alberto Juárez , Cortéz Ma. de los Ángeles López , Roque Helios Mancera 
Published: January 2018

Intraventricular hemorrhage (HIV) is a complication in neonates. It originates in the subependymal germinal matrix. This area is irrigated by a network of poorly differentiated vessels without a basement membrane. Also, it is fragile and vulnerable to the hemodynamic instability of cerebral blood flow. It is an important risk factor for periventricular leukomalacia, ventriculomegaly, and hydrocephalus. These neurological pathologies can generate sequelae in the pediatric population such as cerebral palsy (CP). Objective: To identify the factors associated with HIV in neonates treated in the early intervention program of the hospital of specialties of the child and the woman of the Secretary of Health of the State of Querétaro (HENMSESEQ). Material and Methods: Through the review of the clinical files, the factors associated with HIV present in the children attended to in the HENMSESEQ early intervention service were observed in 2015. Cases of HIV were corroborated by means of transfontanel ultrasound, statistical analysis with measures of central tendency, and comparison of the medians of children diagnosed with HIV and without diagnosis. Results: A group of 69 infants attended to in the early intervention program was studied. Out of them, 65.2% (45) were women and 34.3% (24) were men. They had a gestational age of 34.19 ± 4.22 weeks, birth weight of 2116.09 ± 859.36 g, and height of 44.06 ± 6.02 cm. Their stay in the Neonatal Intensive Care Unit (NICU) for the sample was 11.88 ± 16.84 days and they were 8.65 ± 12.20 days with invasive mechanical ventilation. There were 25 cases of HIV diagnosed by transfontanel ultrasound. Out of the 25 cases, 7 (10%) were HIV grade I, 14 (20%) II, 4 (5.7%) III, and no cases of grade IV were diagnosed. Using the Mann-Whitney U test, a difference was found between the groups of neonates diagnosed with HIV and without diagnosis in weeks of gestation, height, weight, APGAR, days of intubation, and days of stay in NICU.
PENGGUNAAN GENERATOR HHO PADA SEPEDA MOTOR DENGAN MENGGUNAKAN SISTEM BI-FUEL DENGAN VARIASI LARUTAN ELEKTROLIT
Authors: Bela Persada Anggun Angkasa , N Ika Kusuma , Abrar M. Khairul 
Published: January 2018

Transport is one of the main community needs, but along with the increasing number of transport such as motorcycles and increasing also use of fuel oil.While fuel oil are currently derived from fossil where is not sustainable, alternative fuel can use water as fuel, by the process elektrolysis. Water is a compound composed of hydrogen and oxygen, both compound this is a flammable that can be used as alternative fuel or known as gas HHO . When used alternative fuel, gas HHO used along with fuel oil (bi-fuel) .This research discussed of the use of a generator HHO (tool gas producer HHO) on a motorcycle to a variation with an electrolyte namely fresh water, sea water and aquadesh in order to know some of the form a generator HHO that is the generator, the rate of the production of gas and efficiency of gas. This research obtained the best grades HHO power generator at 6.01 watts , the rate of the production of gas by 0.015 and efficiency as much as 1,265 when using aquades.
Keywords: HHO, HHO generator, electrolysis
EVALUASI PERLAKUAN NITRIDASI GAS TEMPERATUR TINGGI TERHADAP STRUKTUR MIKRO, KEKERASAN DAN KETAHANAN AUS BAJA TAHAN KARAT AUSTENIT 316LVM
Authors: Suprihanto Agus 
Published: January 2018

High temperature gas nitriding for austenitic stainless steel 316LVM is successfully done. Specimens are treated at temperature 1323, 1373 and 1573 K for 15 minutes holding time at 0.3 atm nitrogen gas pressures. The effect of nitriding treatments on the hardness, wear resistance and microstructure are evaluated using Buehler microhardness tester, Ogoshi universal wear test machine and light optical microscop respectively. The results shows that hardness, wear resistance and grain size increase with treatments temperature.
Keywords: high temperature gas nitriding, 316LVM, hardness, wear, grain size