bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing the Use of Personal Values to Promote Medication Adherence: A Randomized Controlled Trial Comparing Affective and Behavioral Responses to Theory-Driven Domain Congruent Versus Incongruent Values Approaches
Authors: Finkelstein Lauren B , Bright Emma E , Gu Heng Chao J , Arch Joanna J 
Published: October 2024

Abstract

Background
Self-affirmation theory (SAT) and acceptance and commitment therapy (ACT) embody competing approaches to leveraging personal values to motivate behavior change but are rarely compared in the domain of health behavior. This study compares these theory-driven values-based interventions for promoting medication adherence.

Purpose
To compare affective and behavioral responses to competing values-based medication adherence interventions.

Methods
In this three-armed randomized trial, participants with cancer (n = 95) or diabetes (n = 97) recruited online using Prolific and prescribed daily oral medication for that disease completed a one-session online writing intervention leveraging (1) a domain incongruent (DI) value, where the value was not connected to medication adherence; (2) a domain congruent (DC) value, where the value was connected to adherence; or (3) a control condition, focused on medication adherence procedures.

Results
There were no main effects of conditions on reported medication adherence at the 1-month follow-up. During the intervention, positive affect was higher in the values conditions than control (p &lt; .001), and trended higher in DI versus DC (p = .054). Negative affect did not vary between the values and control groups (p = .093) but was lower in DI versus DC (p = .006). Improvements in positive affect over the course of the intervention were associated with increased adherence behavior for individuals who started with low levels of positive affect (p = .003). Disease type did not moderate findings.

Conclusions
Consistent with SAT, focusing on DI values led to more positive and less negative affect than connecting values directly to behavior in a threatening domain such as chronic illness. For some participants, increases in positive affect predicted greater adherence.
Crushing obstacles: A case series on alternative letermovir administration in transplant recipients
Authors: Tran Nikki , Tossey Justin , Fallah Tara 
Published: October 2024

Abstract

Purpose
Letermovir is used primarily for cytomegalovirus (CMV) prophylaxis in select hematopoietic cell or solid organ transplant recipients. The manufacturer has provided no guidance on whether letermovir can be crushed and administered via enteral tube. This study aimed to assess whether letermovir tablets could be manipulated (eg, through crushing) for enteral tube administration.

Methods
This was a retrospective, single-center review of patients who received crushed letermovir tablets administered via enteral tube for at least 7 days, between April 2018 and August 2023. Data collection focused on demographics, transplant history, treatment characteristics associated with letermovir, and diagnosis of CMV viremia or disease.

Results
Fourteen patients met the inclusion criteria for the review and received crushed letermovir for a median of 19 days (range, 7 to 42 days). All patients were on letermovir as CMV prophylaxis, the majority of whom were lung transplant recipients. On the basis of CMV serostatus at the time of transplantation, 50% of patients were classified as being at high risk and the other 50% were in the intermediate-risk category for CMV disease. One patient developed low-level viremia with a CMV viral load of 254 IU/mL. No patients developed CMV infection or disease while receiving crushed letermovir.

Conclusion
On the basis of this case series, manipulation of letermovir immediate-release tablets was proven to be safe and effective for patients. Crushing letermovir for administration via enteral tube should be considered as an option for patients who cannot tolerate administration via the oral route.
Do job demands and resources differ between permanent and temporary eldercare workers in Sweden?
Authors: Lögdal Nestor , Svensson Sven , Jackson Jennie , Mathiassen Svend Erik , Bergström Gunnar , Hallman David M 
Published: October 2024

Abstract

Introduction
Eldercare organizations face high sickness absence rates and staff turnover and rely heavily on temporary workers to fill staffing gaps. Temporary workers may experience differences in job demands and resources compared with permanent workers, but this has been largely understudied.

Objective
To compare perceived job demands and resources between permanent and temporary Swedish eldercare workers.

Methods
Permanent and temporary eldercare workers in a Swedish municipality were invited to answer a digital survey on work environment conditions. Differences between permanent and temporary workers in job demands and resources were analyzed using multivariate analysis of variance adjusted for age, sex, place of birth, and percent of full-time work and univariate analyses were conducted to consider differences in specific factors.

Results
A total of 1076 permanent and 675 temporary workers received the survey, and the final study sample included 451 permanent and 151 temporary workers. Multivariate analyses revealed that temporary workers reported statistically significant lower job demands compared to permanent workers, but no statistically significant differences in resources were found between the groups. Univariate analyses showed that temporary workers reported lower quantitative demands, perceived exertion, and time spent bending forward, than permanent workers. These data suggest comparable support across groups, but a higher workload among permanent workers.

Conclusion
Our findings indicate that temporary workers experienced lower job demands than permanent workers, but that no notable difference was found in resources. Interventions aimed at distributing job demands more evenly among eldercare workers with different employment forms may be necessary.
Identification of linalool disaccharide glycoside (linalyl β-vicianoside) in soybean leaves and its implication for herbivore resistance
Authors: Ntoruru Juliano Mwenda , Osawa Tsukiho , Ohnishi Toshiyuki , Matsui Kenji 
Published: October 2024

Abstract
Linalool is anticipated to have significant ecological roles. In this study, linalyl 6-O-α-arabinopyranosyl-β-d-glucopyranoside (linalyl β-vicianoside: LinVic) was synthesized, and a linalool diglycoside purified from soybean leaves was identified as LinVic by using liquid chromatography–mass spectrometry. High levels of LinVic were detected in leaves and sepals during soybean plant growth. The LinVic content did not significantly increase following methyl jasmonate treatment of the leaves, indicating that its synthesis is independent of the jasmonic acid signaling pathway. In addition to LinVic, soybean also contains 1-octen-3-yl primeveroside. We treated soybean leaves with vaporized linalool and 1-octen-3-ol to determine whether the glycosylation system discriminates between these 2 volatile alcohols. Linalool treatment resulted in the accumulation of LinVic, while 1-octen-3-ol treatment caused little change in the amount of 1-octen-3-yl primeveroside, suggesting discrimination between these compounds. Linalool-treated soybean leaves exhibited increased resistance against common cutworms, indicating that LinVic may contribute to herbivore resistance.
Novel compound, pleuropyronine, and other polyketides isolated from the edible mushroom Pleurotus ostreatus suppress bacterial biofilm formation
Authors: De Padua Jewel C , Kikuchi Takashi , Sakakibara Futa , De Leon Angeles M , Bungihan Melfei E , Ueno Kotomi , dela Cruz Thomas Edison E , Ishihara Atsushi 
Published: October 2024

Abstract
An increase in the number of drug-resistant microbes is a major threat to human health. Bacterial drug resistance is mostly mediated by biofilm formation. In this study, the culture filtrate from the edible mushroom, Pleurotus ostreatus, was fractionated to isolate compounds that inhibit the biofilm formation of six pathogenic bacteria. Notably, we isolated compounds 1-6 using bioassay-guided chromatographic separations. Spectroscopic and X-ray diffraction analyses identified 1 as a novel fused bicyclic pyrone-furan, named pleuropyronine, whereas 2-6 were known polyketides. Pleuropyronine inhibited biofilm formation in four Gram-negative bacteria, with IC50 values ranging from 5.4 to 8.7 µg/mL, whereas 2-6 exhibited IC50 values between 1.0 and 5.3 µg/mL against five bacteria. Additionally, pleuropyronine bioactivity was confirmed by the inhibition of exopolysaccharide and biofilm formation induced by C6-homoserine lactone. Thus, this may serve as a pioneering study on the pharmacological potential of isolated compounds, offering valuable insights for future research.
Building multiscale models with PhysiBoSS, an agent-based modeling tool
Authors: Ruscone Marco , Checcoli Andrea , Heiland Randy , Barillot Emmanuel , Macklin Paul , Calzone Laurence , Noël Vincent 
Published: October 2024

Abstract
Multiscale models provide a unique tool for analyzing complex processes that study events occurring at different scales across space and time. In the context of biological systems, such models can simulate mechanisms happening at the intracellular level such as signaling, and at the extracellular level where cells communicate and coordinate with other cells. These models aim to understand the impact of genetic or environmental deregulation observed in complex diseases, describe the interplay between a pathological tissue and the immune system, and suggest strategies to revert the diseased phenotypes. The construction of these multiscale models remains a very complex task, including the choice of the components to consider, the level of details of the processes to simulate, or the fitting of the parameters to the data. One additional difficulty is the expert knowledge needed to program these models in languages such as C++ or Python, which may discourage the participation of non-experts. Simplifying this process through structured description formalisms—coupled with a graphical interface—is crucial in making modeling more accessible to the broader scientific community, as well as streamlining the process for advanced users. This article introduces three examples of multiscale models which rely on the framework PhysiBoSS, an add-on of PhysiCell that includes intracellular descriptions as continuous time Boolean models to the agent-based approach. The article demonstrates how to construct these models more easily, relying on PhysiCell Studio, the PhysiCell Graphical User Interface. A step-by-step tutorial is provided as Supplementary Material and all models are provided at https://physiboss.github.io/tutorial/.
Unilateral heliotrope rash: first sign of paraneoplastic anti-TIF1γ dermatomyositis
Authors: Antunes-Duarte Sofia , Mancha Dora , Brazão Cláudia , Sun Lanyu , Pereira da Costa Roberto , Campanilho-Marques Raquel , Romeu José Carlos , Santos Tiago , de Vasconcelos Pedro , Soares-de-Almeida Luís , Filipe Paulo 
Published: October 2024

Unilateral heliotrope rash is a potential, eventually sole, manifestation of dermatomyositis (DM).
The detection of anti-TIF1γ autoantibodies is a valuable tool for identifying patients with DM with a higher risk of cancer, warranting comprehensive screening, and aiding the diagnosis of DM with atypical clinical presentations.
Risk of suicide and suicidality in patients with moderate to severe psoriasis: results from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR)
Authors: Williams Kerry , Lada Georgia , Reynolds Nick J , Mcelhone Kathleen , Evans Ian , Warren Richard B , Walton Shernaz , Hughes Olivia , Bewley Anthony , Mason Kayleigh , Kleyn C Elise 
Published: October 2024

Abstract

Background
Psoriasis is associated with poor mental health and reduced quality of life. Although the high risk for depression in patients with psoriasis is well established, the suicidality risk among these patients is uncertain. Previous studies provide contrasting results and have not included patients with clinically confirmed severe disease.

Objectives
To determine the risk of suicide among patients with moderate to severe psoriasis and to compare it with that of the general population, and to investigate if psychiatric comorbidity or history of suicidality increases future suicidality risk in psoriasis. We further estimated the incidence of suicidal and self-injurious behaviours in patients.

Methods
Analysis was performed using the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR). General population mortality and suicide data were used as controls.

Results
There were nine suicides in BADBIR. The incidence rate of suicide was 12.5 per 100 000 person-years [95% confidence interval (CI) 6.53–24.11] in BADBIR vs. 11.0 per 100 000 person-years (95% CI 10.7–11.3) in the general population in England and Wales. Among patients, psychiatric comorbidity or past suicidality was associated with a higher risk for suicidal ideation, suicide attempts and self-injurious behaviours.

Conclusions
The suicide rate among patients with moderate to severe psoriasis was not significantly higher when compared with the general population. Suicide is a rare event and our results are limited by uncertainty about the reliability of the estimate. However, considering the high depression prevalence in psoriasis, our findings support the need for prompt assessment of patients for psychiatric comorbidities and suicidality history. Further research is required on suicidal behaviours and the role of psoriasis severity.
Acne-related quality of life and mental health among adolescents: a cross-sectional analysis
Authors: Dumont Shireen , Lorthe Elsa , Loizeau Andrea , Richard Viviane , Nehme Mayssam , Posfay-Barbe Klara M , Barbe Rémy P , Toutous Trellu Laurence , Stringhini Silvia , Guessous Idris , Dumont Roxane ,   the SEROCoV-KIDS study group, Azman Andrew S , Bal Antoine , Barbe Rémy P , Baysson Hélène , Bouchet Aminata R , D’Ippolito Paola , Dumont Roxane , El Merjani Nacira , Pennacchio Francesco , Francioli Natalie , Guessous Idris , Harnal Séverine , Lamour Julien , L’Huillier Arnaud G , Loizeau Andrea , Lorthe Elsa , Martinez Chantal , Mechoullam Shannon , Nehme Mayssam , Posfay-Barbe Klara M , Poulain Géraldine , Pugin Caroline , Pullen Nick , Richard Viviane , Rochat Deborah , Samir Khadija , Schrempft Stephanie , Stringhini Silvia , Testini Stéphanie , Rivas Deborah Urrutia , Uppal Anshu , Verolet Charlotte , Villers Jennifer , Violot Guillemette , Zaballa María-Eugenia 
Published: October 2024

Abstract

Background
Acne vulgaris is one of the most common skin conditions worldwide among adolescents. Beyond its physical manifestations, acne can leave invisible psychological scars.

Objectives
We aimed to examine the protective and risk factors of acne-related quality of life and its association with mental health outcomes.

Methods
The analysis included data collected in 2023 from adolescents enrolled in the SEROCoV-KIDS population-based cohort. By combining the Acne Severity and Acne-Specific Quality of Life (Acne-QoL) scales, the following three groups were established: Acne-LowAQoL (adolescents with acne and low acne-related quality of life), Acne-HighAQoL and NoAcne-HighAQoL. We used multinomial and logistic regression to assess the association between health behaviours and mental health outcomes in these groups.

Results
Among 335 adolescents [mean age 16.1 years (SD 1.8), 56% female sex], 65 (19.4%) reported experiencing acne while maintaining a high Acne-QoL, 26 (7.7%) reported having acne and a low Acne-QoL, and 244 (72.9%) reported having nearly no acne. Low engagement in physical activity [adjusted odds ratio (aOR) 0.30, 95% confidence interval (CI) 0.12–0.77], addictive use of social media (aOR 3.78, 95% CI 1.60–8.96), and prolonged screen time (aOR 2.99, 95% CI 1.26–7.08) were independently associated with Acne-LowAQoL. Conversely, those from the group, Acne-HighAQoL, reported higher social support (aOR 1.95, 95% CI 1.07–3.54). Adolescents with Acne-LowAQoL showed lower levels of self-esteem, resilience and increased psychological distress.

Conclusions
Among adolescents with acne, physical activity and social support were positively associated with good acne-related quality of life, which translated into better mental health. In contrast, screen time and social media use notably worsened mental health. Dermatologists should incorporate these considerations into clinical practice to ensure effective patient care.
Tixagevimab–cilgavimab for preventing breakthrough COVID-19 in dialysis patients: a prospective study
Authors: Boongird Sarinya , Srithongkul Thatsaphan , Sethakarun Sethanant , Bruminhent Jackrapong , Kiertiburanakul Sasisopin , Nongnuch Arkom , Kitiyakara Chagriya , Sritippayawan Suchai 
Published: October 2024

ABSTRACT

Background
The effectiveness of tixagevimab–cilgavimab as pre-exposure prophylaxis (PrEP) against breakthrough coronavirus disease 2019 (COVID-19) in dialysis patients remains uncertain due to limited data.

Methods
In this multicenter prospective study, we enrolled vaccinated dialysis patients and divided them into two groups: a tixagevimab–cilgavimab group (received a 150 mg/150 mg intramuscular dose of tixagevimab–cilgavimab) and a control group (age-matched patients not receiving tixagevimab–cilgavimab). The primary outcome was the breakthrough COVID-19 rate at 6 months, whereas secondary outcomes included COVID-19-related hospitalization, intensive care unit admission, endotracheal intubation and mortality. The safety of tixagevimab–cilgavimab was assessed.

Results
Two hundred participants were enrolled, with equal numbers in each group (n = 100 each). Baseline characteristics were comparable between groups, except for a higher number of COVID-19 vaccine doses in the tixagevimab–cilgavimab group [median (IQR) 4 (3–5) vs. 3 (3–4); P = .01]. At 6 months, the breakthrough COVID-19 rates were comparable between the tixagevimab–cilgavimab (17%) and control (15%) groups (P = .66). However, the median (IQR) time to diagnosis of breakthrough infections tended to be longer in the tixagevimab–cilgavimab group [4.49 (2.81–4.98) vs 1.96 (1.65–2.91) months; P = .08]. Tixagevimab–cilgavimab significantly reduced COVID-19-related hospitalization rates (5.9% vs 40.0%; P = .02) among participants with breakthrough infections. All tixagevimab–cilgavimab-related adverse events were mild.

Conclusion
The use of tixagevimab–cilgavimab as PrEP in vaccinated dialysis patients during the Omicron surge did not prevent breakthrough infections but significantly reduced COVID-19-related hospitalizations. Further research should prioritize alternative strategies.
On robust inference in time-series regression
Authors: Baillie Richard T , Diebold Francis X , Kapetanios George , Kim Kun Ho , Mora Aaron 
Published: October 2024

Summary
Least squares regression with heteroskedasticity consistent standard errors (‘OLS-HC regression’) has proved very useful in cross-section environments. However, several major difficulties, which are generally overlooked, must be confronted when transferring the HC technology to time-series environments via heteroskedasticity and autocorrelation consistent standard errors (‘OLS-HAC regression’). First, in plausible time-series environments, OLS parameter estimates can be inconsistent, so that OLS-HAC inference fails even asymptotically. Second, most economic time series have autocorrelation, which renders OLS parameter estimates inefficient. Third, autocorrelation similarly renders conditional predictions based on OLS parameter estimates inefficient. Finally, the structure of popular HAC covariance matrix estimators is ill-suited for capturing the autoregressive autocorrelation typically present in economic time series, which produces large size distortions and reduced power in HAC-based hypothesis testing, in all but the largest samples. We show that all four problems are largely avoided by the use of a simple and easily implemented dynamic regression procedure, which we call DURBIN. We demonstrate the advantages of DURBIN with detailed simulations covering a range of practical issues.
Seasonal activity and phoresy rates of Nitidulid beetles (Coleoptera: Nitidulidae) captured in stands with oak wilt infections in northern Michigan, USA
Authors: Morris Olivia R , Chahal Karandeep , Cregg Bert , Sharma Nancy , Wieferich James , Sakalidis Monique L , McCullough Deborah G 
Published: October 2024

Abstract
Nitidulid beetles (Coleoptera: Nitidulidae), the overland vectors of the Bretziella fagacearum fungus that causes oak wilt, were monitored in infection centers in Quercus rubra stands in northern Michigan, USA using baited, wind-oriented traps for 2 years. First nitidulid captures, accounting for &lt;1.5% of total annual captures, occurred in late April in both years (&lt;50 cumulative degree days [DDs]; base 10°C). A total of 1,188 and 735 beetles representing 19 and 18 species were captured in 2018 (18 traps; 3 sites) and 2019 (16 traps; 4 sites), respectively. Ground traps (1.5 m high) captured more beetles and species than traps on canopy branches of red oaks. Most nitidulids (81–86%) were captured in May and June, but frequent precipitation and cool spring temperatures extended activity into early July in 2019. In 2018, 336 beetles representing 12 species were screened for B. fagacearum spores, but only 20 beetles from 4 species bore viable spores. Mycelial mats on red oaks killed were 4-fold more abundant in 2019 than in 2018. Of the 225 beetles screened in 2019, 56 beetles representing 6 species had viable spores. Nearly all (96%) spore-bearing beetles in both years were captured in late May or June. In bimonthly xylem samples collected from healthy trees, large earlywood vessels, presumably more vulnerable to infection than latewood, were present from May to June in 2018 and until early July in 2019. Results are consistent with mid-May to mid-July high-risk periods designated in current state and regional guidelines for oak wilt management.