bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bespoke mobile application for the longitudinal assessment of depression and mood during pregnancy: protocol of a feasibility study
Authors: Marcano Belisario Jose Salvador , Doherty Kevin , O'Donoghue John , Ramchandani Paul , Majeed Azeem , Doherty Gavin , Morrison Cecily , Car Josip 
Published: May 2017

IntroductionDepression is a common mental health disorder during pregnancy, with important consequences for mothers and their children. Despite this, it goes undiagnosed and untreated in many women attending antenatal care. Smartphones could help support the prompt identification of antenatal depression in this setting. In addition, these devices enable the implementation of ecological momentary assessment techniques, which could be used to assess how mood is experienced during pregnancy. With this study, we will assess the feasibility of using a bespoke mobile application (app) running on participants’ own handsets for the longitudinal (6 months) monitoring of antenatal mood and screening of depression.Methods and analysisWe will use a randomised controlled study design to compare two types of assessment strategies: retrospective + momentary (consisting of the Edinburgh Postnatal Depression Scale plus five momentary and two contextual questions), and retrospective (consisting of the Edinburgh Postnatal Depression Scale only). We will assess the impact that these strategies have on participant adherence to a prespecified sampling protocol, dropout rates and timeliness of data completion. We will evaluate differences in acceptance of the technology through a short quantitative survey and open-ended questions. We will also assess the potential effect that momentary assessments could have on retrospective data. We will attempt to identify any patterns in app usage through the analysis of log data.Ethics and disseminationThis study has been reviewed and approved by the National Research Ethics Service Committee South East Coast—Surrey on 15 April 2016 as a notice of substantial amendment to the original submission (9 July 2015) under the Research Ethics Committee (REC) reference 15/LO/0977. This study is being sponsored by Imperial College London under the reference number 15IC2687 and has been included in the UK Clinical Research Network Study Portfolio under the Central Portfolio Management System number 19280. The findings of this study will be disseminated through academic peer-reviewed publications, poster presentations and abstracts at academic and professional conferences, discussion with peers, and social media. The findings of this study will also inform the PhD theses of JSMB and KD.
Selection by a panel of clinicians and family representatives of important early morbidities associated with paediatric cardiac surgery suitable for routine monitoring using the nominal group technique and a robust voting process
Authors: Pagel Christina , Brown Katherine L , McLeod Isobel , Jepps Helen , Wray Jo , Chigaru Linda , McLean Andrew , Treasure Tom , Tsang Victor , Utley Martin 
Published: May 2017

ObjectiveWith survival following paediatric cardiac surgery improving, the attention of quality assurance and improvement initiatives is shifting to long-term outcomes and early surgical morbidities. We wanted to involve family representatives and a range of clinicians in selecting the morbidities to be measured in a major UK study.SettingPaediatric cardiac surgery services in the UK.ParticipantsWe convened a panel comprising family representatives, paediatricians from referring centres, and surgeons and other clinicians from surgical centres.Primary and secondary outcome measuresUsing the nominal group technique augmented by a robust voting process to identify group preferences, suggestions for candidate morbidities were elicited, discussed, ranked and then shortlisted. The shortlist was passed to a clinical group that provided a view on the feasibility of monitoring each shortlisted morbidity in routine practice. The panel then met again to select a prioritised list of morbidities for further study, with the list finalised by the clinical group and chief investigators.ResultsAt the first panel meeting, 66 initial suggestions were made, with this reduced to a shortlist of 24 after two rounds of discussion, consolidation and voting. At the second meeting, this shortlist was reduced to 10 candidate morbidities. Two were dropped on grounds of feasibility and replaced by another the panel considered important. The final list of nine morbidities included indicators of organ damage, acute events and feeding problems. Family representatives and clinicians from outside tertiary centres brought some issues to greater prominence than if the panel had consisted solely of tertiary clinicians or study investigators.ConclusionThe inclusion of patient and family perspectives in identifying metrics for use in monitoring a specialised clinical service is challenging but feasible and can broaden notions of quality and how to measure it.
Long-term antibiotics for prevention of recurrent urinary tract infection in older adults: systematic review and meta-analysis of randomised trials
Authors: Ahmed Haroon , Davies Freya , Francis Nick , Farewell Daniel , Butler Christoper , Paranjothy Shantini 
Published: May 2017

ObjectiveTo address clinical uncertainties about the effectiveness and safety of long-term antibiotic therapy for preventing recurrent urinary tract infections (UTIs) in older adults.DesignSystematic review andmeta-analysis of randomised trials.MethodWe searched Medline, Embase, TheCumulative Index to Nursing and Allied Health Literature(CINAHL), and the Cochrane Register of Controlled Trials from inception to August 2016. Eligible studies compared long-term antibiotic therapy with non-antibiotic therapy or placebo in men or women aged over 65, or in postmenopausal women, with recurrent UTIs.ResultsWe did not identify any studies that included older men. Three randomised controlled trials compared long-term antibiotics with vaginal oestrogens (n=150), oral lactobacilli (n=238) and D-mannose powder (n=94) in postmenopausal women. Long-term antibiotics reduced the risk of UTI recurrence by 24% (three trials, n=482; pooled risk ratio (RR) 0.76; 95% CI 0.61 to 0.95, number needed to treat=8.5). There was no statistically significant increase in risk of adverse events (mild adverse events: pooled RR 1.52; 95% CI 0.76 to 3.03; serious adverse events: pooled RR 0.90, 95% CI 0.31 to 2.66). One trial showed 90% of urinary and faecalEscherichia coliisolates were resistant to trimethoprim–sulfamethoxazole after 1 month of prophylaxis.ConclusionsFindings from three small trials with relatively short follow-up periods suggest long-term antibiotic therapy reduces the risk of recurrence in postmenopausal women with recurrent UTI. We did not identify any evidence to inform several clinically important scenarios including, benefits and harms in older men or frail care home residents, optimal duration of prophylaxis, recurrence rates once prophylaxis stops and effects on urinary antibiotic resistance.
Systemic glucocorticoid use in Denmark: a population-based prevalence study
Authors: Laugesen Kristina , Jørgensen Jens Otto Lunde , Sørensen Henrik Toft , Petersen Irene 
Published: May 2017

ObjectivesGlucocorticoid (GC) use is widespread and associated with many adverse effects. Thus, it is important to ascertain GC utilisation patterns. In this study, we examined the annual prevalence of prescription users and amount of use of systemic GCs.DesignPopulation-wide prevalence study.SettingThe primary healthcare and hospital sectors in Denmark from 1999 to 2015.ResultsApproximately 3% of the Danish population redeemed at least one prescription for a systemic GC annually between 1999 and 2015, with annual prevalence remaining constant over the period. However, after adjusting for age and sex, we observed a decrease in annual prevalence from 1999 to 2015, with a prevalence ratio of 0.92 (95% CI 0.91 to 0.92). Annual prevalence was highest among the elderly (7.0%–8.2% among persons 65–79 years of age and 8.4%–10% among persons 80+ years of age). Prednisolone was the most frequently redeemed systemic GC, with annual prevalence increasing from 1.4% to 2.1% during the 1999–2015 period. The amount of systemic GCs provided to the hospital sector increased from 2.3 defined daily doses (DDD)/1000 inhabitants/day in 1999 to 3.5 DDD/1000 inhabitants/day in 2015, while the amount provided to the primary healthcare sector remained constant in the range of 10–11 DDD/1000 inhabitants/day.ConclusionWe found a high prevalence of systemic GC use of 3% with a remarkably high prevalence in elderly of up to 10%, wherefore continued awareness of its effects is mandated.
Developing a core outcome set for infant colic for primary, secondary and tertiary care settings: a prospective study
Authors: Steutel Nina F , Benninga Marc A , Langendam Miranda W , Korterink Judith J , Indrio Flavia , Szajewska Hania , Tabbers Merit M 
Published: May 2017

ObjectiveInfant colic (IC) is defined as recurrent and prolonged crying without an obvious cause or evidence of failure to thrive or illness. It is a common problem with a prevalence of 5%–25%. The unknown aetiology results in a wide variety in interventions and use of heterogeneous outcome measures across therapeutic trials. Our aim was to develop a core outcome set (COS) for IC to facilitate and improve evidence synthesis.Design and settingProspective study design; primary, secondary and tertiary care.MethodsThe COS was developed using a modified Delphi technique. First, healthcare professionals (HCPs) and parents of infants with IC were asked to list up to five outcomes they considered relevant in the treatment of IC. Outcomes mentioned by >10% of participants were forwarded to a shortlist. In the second round, outcomes on this shortlist were rated and prioritised. The final COS was defined in a face-to-face expert meeting of paediatricians.ResultsF of invited stakeholders (133 HCPs and 55 parents of infants with IC) completed both Delphi rounds. Duration of crying, family stress, sleeping time of infant, quality of life (of family), discomfort of infant and hospital admission/duration were rated as most important outcomes in IC, framing the final COS.ConclusionsThe use of this COS should serve as a minimum of outcomes to be measured and reported. This will benefit evidence synthesis, by enhancing homogeneity of outcomes, and enable evaluation of success in therapeutic trials on IC. Researchers are strongly encouraged to use this COS when setting up a clinical trial in primary, secondary and/or tertiary care or performing a systematic review on IC.
Selecting children with suspected inflammatory bowel disease for endoscopy with the calgranulin C or calprotectin stool test: protocol of the CACATU study
Authors: Heida Anke , Van de Vijver Els , Muller Kobold Anneke , van Rheenen Patrick 
Published: May 2017

IntroductionThe introduction of the faecal calprotectin (FC) test to screen children with chronic gastrointestinal complaints has helped the clinician to decide whether or not to subject the patient to endoscopy. In spite of this, a considerable number of patients without inflammatory bowel disease (IBD) is still scoped. Faecal calgranulin C (S100A12) is a marker of intestinal inflammation that is potentially more specific for IBD than FC, as it is exclusively released by activated granulocytes.ObjectiveTo determine whether the specificity of S100A12 is superior to the specificity of FC without sacrificing sensitivity in patients with suspected IBD.MethodsAn international prospective cohort of children with suspected IBD will be screened with the existing FC stool test and the new S100A12 stool test. The reference standard (endoscopy with biopsies) will be applied to patients at high risk of IBD, while a secondary reference (clinical follow-up) will be applied to those at low risk of IBD. The differences in specificity and sensitivity between the two markers will be calculated.Ethics and disseminationThis study is submitted to and approved by the Medical Ethics Review Committee of the University Medical Center Groningen (the Netherlands) and the Antwerp University Hospital (Belgium). The results will be disseminated through a peer-reviewed publication, conference presentation and incorporation in the upcoming National Guideline on Diagnosis and Therapy of IBD in Children.Trial registrationClinicalTrials.gov identifier:NCT02197780.
Chiral perturbation theory and nucleon–pion-state contaminations in lattice QCD
Authors: Bär Oliver 
Published: May 2017

Multiparticle states with additional pions are expected to be a non-negligible source of excited-state contamination in lattice simulations at the physical point. It is shown that baryon chiral perturbation theory can be employed to calculate the contamination due to two-particle nucleon–pion-states in various nucleon observables. Leading order results are presented for the nucleon axial, tensor and scalar charge and three Mellin moments of parton distribution functions (quark momentum fraction, helicity and transversity moment). Taking into account phenomenological results for the charges and moments the impact of the nucleon–pion-states on lattice estimates for these observables can be estimated. The nucleon–pion-state contribution results in an overestimation of all charges and moments obtained with the plateau method. The overestimation is at the 5–10% level for source-sink separations of about 2 fm. The source-sink separations accessible in contemporary lattice simulations are found to be too small for chiral perturbation theory to be directly applicable.
Magnocellular Bias in Exogenous Attention to Biologically Salient Stimuli as Revealed by Manipulating Their Luminosity and Color
Authors: Carretié Luis , Kessel Dominique , García-Rubio María J. , Giménez-Fernández Tamara , Hoyos Sandra , Hernández-Lorca María 
Published: May 2017

AbstractExogenous attention is a set of mechanisms that allow us to detect and reorient toward salient events—such as appetitive or aversive—that appear out of the current focus of attention. The nature of these mechanisms, particularly the involvement of the parvocellular and magnocellular visual processing systems, was explored. Thirty-four participants performed a demanding digit categorization task while salient (spiders or S) and neutral (wheels or W) stimuli were presented as distractors under two figure–ground formats: heterochromatic/isoluminant (exclusively processed by the parvocellular system, Par trials) and isochromatic/heteroluminant (preferentially processed by the magnocellular system, Mag trials). This resulted in four conditions: SPar, SMag, WPar, and WMag. Behavioral (RTs and error rates in the task) and electrophysiological (ERPs) indices of exogenous attention were analyzed. Behavior showed greater attentional capture by SMag than by SPar distractors and enhanced modulation of SMag capture as fear of spiders reported by participants increased. ERPs reflected a sequence from magnocellular dominant (P1p, ≃120 msec) to both magnocellular and parvocellular processing (N2p and P2a, ≃200 msec). Importantly, amplitudes in one N2p subcomponent were greater to SMag than to SPar and WMag distractors, indicating greater magnocellular sensitivity to saliency. Taking together, results support a magnocellular bias in exogenous attention toward distractors of any nature during initial processing, a bias that remains in later stages when biologically salient distractors are present.
Bulbophyllum jingdongense (Orchidaceae), a new species in the Cirrhopetalum alliance from South China and Laos
Authors: HU AI-QUN , YE DE-PING , GALE STEPHAN W. , SAUNDERS RICHARD M. K. , FISCHER GUNTER A. , LI JIAN-WU 
Published: May 2017

Bulbophyllum jingdongense, a new species from South China and Laos belonging to the Cirrhopetalum alliance (Orchidaceae), is described and illustrated. It is morphologically distinct from all other known species in the alliance on account of the following diagnostic characters: pseudobulbs compressed subglobose; sepals and petals with dense, reddish-purple papillae on abaxial surfaces; lateral sepals basally connivent along their lower edges, the upper edges strongly incurved and connivent at the middle and then becoming separate again towards their incurved, horn-shaped, obtuse apex; column with a single orange-yellow gland below the stigma; and stelidia well-developed, 2.5–3 mm long, truncate at base, acuminate, merging with the column wings on each side of the column. The conservation status of B. jingdongense is assessed and taxonomic notes are provided.
Drivers and Environmental Responses to the Changing Annual Snow Cycle of Northern Alaska
Authors: Cox Christopher J. , Stone Robert S. , Douglas David C. , Stanitski Diane M. , Divoky George J. , Dutton Geoff S. , Sweeney Colm , George J. Craig , Longenecker David U. 
Published: May 2017

AbstractLinkages between atmospheric, ecological, and biogeochemical variables in the changing Arctic are analyzed using long-term measurements near Utqiaġvik (formerly Barrow), Alaska. Two key variables are the date when snow disappears in spring, as determined primarily by atmospheric dynamics, precipitation, air temperature, winter snow accumulation, and cloud cover, and the date of onset of snowpack in autumn that is additionally influenced by ocean temperature and sea ice extent. In 2015 and 2016 the snow melted early at Utqiaġvik owing mainly to anomalous warmth during May of both years attributed to atmospheric circulation patterns, with 2016 having the record earliest snowmelt. These years are discussed in the context of a 115-yr snowmelt record at Utqiaġvik with a trend toward earlier melting since the mid-1970s (–2.86 days decade–1, 1975–2016). At nearby Cooper Island, where a colony of seabirds, black guillemots, have been monitored since 1975, timing of egg laying is correlated with Utqiaġvik snowmelt with 2015 and 2016 being the earliest years in the 42-yr record. Ice out at a nearby freshwater lagoon is also correlated with Utqiaġvik snowmelt. The date when snow begins to accumulate in autumn at Utqiaġvik shows a trend toward later dates (+4.6 days decade–1, 1975–2016), with 2016 being the latest on record. The relationships between the lengthening snow-free season and regional phenology, soil temperatures, fluxes of gases from the tundra, and to regional sea ice conditions are discussed. Better understanding of these interactions is needed to predict the annual snow cycles in the region at seasonal to decadal scales and to anticipate coupled environmental responses.
Wintertime Simulations of a Boreal Lake with the Canadian Small Lake Model
Authors: MacKay Murray D. , Verseghy Diana L. , Fortin Vincent , Rennie Michael D. 
Published: May 2017

Abstract
A one-dimensional mixed layer dynamic lake model is enhanced with snow and ice physics for an examination of processes governing ice cover and phenology in a small boreal lake. The complete snowpack physics module of the Canadian Land Surface Scheme along with a new snow-ice parameterization have been added to the Canadian Small Lake Model, and detailed meteorological and temperature profile data have been acquired for the forcing and evaluation of two wintertime simulations. During the first winter, simulated ice-on and ice-off biases were −3 and −5 days, respectively. In the second winter simulation, ice-on bias was larger, likely due to the absence of a frazil ice scheme in the model, and simulated ice-off was 6 days late, evidently due to insufficient convective mixing beneath the ice in the weeks leading up to ice-off. Ice cover was simulated about 25% too thin between January and March for this year, though late January simulated snow and snow-ice amounts were close to observed. The impact of snow-ice production on simulated ice cover and phenology was found to be dramatic for this lake. In the absence of this process, January snow was more than twice as deep as observed and March ice thickness was less than one-third of that observed. Without snow-ice production, a reasonable simulation of ice cover could only be restored if 62% of snowfall was removed ad hoc (e.g., through blowing snow redistribution)—an excessive amount for a small, sheltered boreal lake.
Pilot Study of Universal Newborn Hearing Screening in Japan: District-Based Screening Program in Okayama
Authors: Fukushima Kunihiro , Mimaki Nobuyoshi , Fukuda Shoichiro , Nishizaki Kazunori 
Published: May 2017

Objectives: Newborn hearing screening was started in Okayama Prefecture in 2001 as part of a nationwide pilot study in Japan. Nearly 50,000 infants have been screened to date, and an observational study and more than 2 years of follow-up of this population are described in this report. Methods: Between June 2001 and March 2005 (45 months), 47,346 neonates were screened with automated auditory brain stem response systems and followed up for at least 2 years. This total corresponds to 95% of the infants born in the 44 gynecologic institutions in this district. Results: After undergoing the screening process twice, 248 infants (0.52%) received referrals; 108 of them had apparent bilaterally affected hearing, and 140 had apparent unilaterally affected hearing. Among the bilateral cases, hearing impairment was diagnosed in 40 infants, for a total prevalence of hearing impairment of 0.08%. In 3 additional infants who received a bilateral pass result and 1 infant who received a unilateral pass result, hearing impairment that was progressive or of late onset was subsequently diagnosed. The positive and negative predictive values were calculated as 40% and 99.993%, respectively. Conclusions: The screening program was carefully designed to work in the Japanese society and to be well managed in Okayama Prefecture.
Clinical and Pathologic Predictors of Survival in Patients with Squamous Cell Carcinoma of the Hypopharynx after Surgical Treatment
Authors: Chu Pen-Yuan , Li Wing-Yin , Chang Shyue-Yih 
Published: May 2017

Objectives: Hypopharyngeal squamous cell carcinoma (HPSCC) usually presents at an advanced stage. Although chemo-radiotherapy has become more popular in treating HPSCC in recent years, surgery with postoperative adjuvant therapy still plays an important role. The purpose of this study was to identify the clinicopathologic factors that predict survival in patients with HPSCC who underwent surgical treatment. Methods: Between 1986 and 1995, 94 previously untreated HPSCC patients who underwent surgery with or without postoperative radiotherapy were enrolled. The surgical specimens were reexamined by a single pathologist. The clinicopathologic parameters and prognostic data were analyzed. Results: With a median follow-up of 50 months, the 5-year overall survival (OS), disease-specific survival (DSS), and relapse-free survival (RFS) were 47%, 60%, and 58%, respectively. Thirty-seven patients (39%) had tumor recurrence. The level of lymph node metastasis was an independent factor in OS, DSS, and RFS. Neck biopsy before surgery, tumor involvement of more than 1 subsite, and extracapsular spread were independent factors in DSS, as was lymphovascular permeation in RFS. Conclusions: The level of cervical lymph node metastasis is the only independent prognostic factor in OS, DSS, and RFS. The addition of postoperative chemoradiotherapy may benefit high-risk cases.