bluuebunny/crossref_metadata_2025_split huggingface dataset:
The synthetic histone-binding regulator protein PcTF activates interferon genes in breast cancer cells
Authors: Olney Kimberly C. , Nyer David B. , Vargas Daniel A. , Sayres Melissa A. Wilson , Haynes Karmella A. 
Published: September 2017

ABSTRACTMounting evidence from genome-wide studies of cancer show that chromatin-mediated epigenetic silencing at large cohorts of genes is strongly linked to a poor prognosis. This mechanism is thought to prevent cell differentiation and enable evasion of the immune system. Drugging the cancer epigenome with small molecule inhibitors to release silenced genes from the repressed state has emerged as a powerful approach for cancer research and drug development. Targets of these inhibitors include chromatin-modifying enzymes that can acquire drug-resistant mutations. In order to directly target a generally conserved feature, elevated trimethyl-lysine 27 on histone H3 (H3K27me3), we developed the Polycomb-based Transcription Factor (PcTF), a fusion activator that targets methyl-histone marks via its N-terminal H3K27me3-binding motif, and co-regulates sets of silenced genes. Here, we report transcriptome profiling analyses of PcTF-treated breast cancer model cell lines. We identified a set of 19 PcTF-upregulated genes, or PUGs, that were consistent across three distinct breast cancer cell lines. These genes are associated with the interferon response pathway. Our results demonstrate for the first time a chromatin-mediated interferon-related transcriptional response driven by an engineered fusion protein that physically links repressive histone marks with active transcription.
Origin of Slow Spontaneous Resting-State Neuronal Fluctuations in Brain Networks
Authors: Krishnan Giri P. , González Oscar C. , Bazhenov Maxim 
Published: September 2017

AbstractResting or baseline state low frequency (0.01-0.2 Hz) brain activity has been observed in fMRI, EEG and LFP recordings. These fluctuations were found to be correlated across brain regions, and are thought to reflect neuronal activity fluctuations between functionally connected areas of the brain. However, the origin of these infra-slow fluctuations remains unknown. Here, using a detailed computational model of the brain network, we show that spontaneous infra-slow (< 0.05 Hz) fluctuations could originate due to the ion concentration dynamics. The computational model implemented dynamics for intra and extracellular K+and Na+and intracellular Cl-ions, Na+/K+exchange pump, and KCC2 co-transporter. In the network model representing resting awake-like brain state, we observed slow fluctuations in the extracellular K+concentration, Na+/K+pump activation, firing rate of neurons and local field potentials. Holding K+concentration constant prevented generation of these fluctuations. The amplitude and peak frequency of this activity were modulated by Na+/K+pump, AMPA/GABA synaptic currents and glial properties. Further, in a large-scale network with long-range connections based on CoCoMac connectivity data, the infra-slow fluctuations became synchronized among remote clusters similar to the resting-state networks observedin vivo. Overall, our study proposes that ion concentration dynamics mediated by neuronal and glial activity may contribute to the generation of very slow spontaneous fluctuations of brain activity that are observed as the resting-state fluctuations in fMRI and EEG recordings.
Living hours under pressure: flexibility loopholes in the Danish IR-model
Authors: Ilsøe Anna , Larsen Trine Pernille , Felbo-Kolding Jonas 
Published: September 2017

PurposeThe purpose of this paper is to investigate the effect of part-time work on absolute wages. The empirical focus is wages and working hours in three selected sectors within private services in the Danish labour market – industrial cleaning, retail, hotels and restaurants – and their agreement-based regulation of working time and wages. Theoretically, this analysis is inspired by the concept of living hours, which addresses the interaction between working hours and living wages, but adds a new layer to the concept in that the authors also consider the importance of working time regulations for securing a living wage.Design/methodology/approachThe paper builds on desk research of collective agreements and analysis of monthly administrative register data on wages and working hours of Danish employees from the period 2008-2014.FindingsThis analysis shows that the de facto hourly wages have increased since the global financial crisis in all three sectors. This is in accordance with increasing minimum wage levels in the sector-level agreements. The majority of workers in all three sectors work part-time. Marginal part-timers – 15 hours or less per week – make up the largest group of workers. The de facto hourly wage for part-timers, including marginal part-timers, is relatively close to the sector average. However, the yearly job-related income is much lower for part-time than for full-time workers and much lower than the poverty threshold. Whereas the collective agreement in industrial cleaning includes a minimum floor of 15 weekly working hours – this is not the case in retail, hotels and restaurants. This creates a loophole in the latter two sectors that can be exploited by employers to gain wage flexibility through part-time work.Originality/valueThe living wage literature usually focusses on hourly wages (including minimum wages via collective agreements or legislation). This analysis demonstrates that studies of low-wage work must include the number of working hours and working time regulations, as this aspect can have a dramatic influence on absolute wages – even in cases of hourly wages at relatively high levels. Part-time work and especially marginal part-time work can be associated with very low yearly income levels – even in cases like Denmark – if regulations do not include minimum working time floors. The authors suggest that future studies include the perspective of living hours to draw attention to the effect of low number of weekly hours on absolute income levels.
In defence of a university social work education
Authors: Thoburn June 
Published: September 2017

Purpose
The purpose of this paper is to identify the particular characteristics and strengths of mainstream undergraduate and postgraduate university education for social workers.

Design/methodology/approach
A brief summary of the establishment of the honours degree or M-level qualification as the requirement for registration as a social worker in England is followed by a summary of the main aspects of “mainstream” social work courses. The values underpinning a “student” rather than a “trainee” route into social work are explored and some limited comparisons made with recently introduced fast-track specialist programmes. Where relevant, the student experience is contrasted with that of fast-track specialist trainees.

Findings
The paper concludes with a discussion of the potential impact on the social work profession and on agencies providing social work services of the cuts over the past few years in the numbers of students on “generalist” mainstream social work programmes.

Research limitations/implications
This is a conceptual paper. It recognises that more information is available on long-established university programmes than on the more recently available fast-track routes into social work and cites relevant research.

Practical implications
The paper points to the changing balance between numbers entering social work in England via mainstream and fast-track specialist programmes and argues for a fuller debate amongst all stakeholders as to whether this change is in the interest of the profession and those who need social work services.

Social implications
The author argues that the unequal level of funding between the different entry routes into social work is distorting choice (for students and future employers) between fast-track specialist and mainstream social work education. It is hypothesised that differences between the curricula and learning experiences of the two routes may have an impact on the social work service available to vulnerable people across age and needs groups. It also points to a potentially negative impact on social work education and the knowledge base of the reduction in numbers of academics with both social work practice experiences and research qualifications.

Originality/value
This is an original paper that draws on the author’s experience and the published research and grey literature cited.
Child protection in England: an emerging inequalities perspective
Authors: Bywaters Paul , Sparks Tim 
Published: September 2017

PurposeIn the past 40 years, both health policy and educational policy in England have adopted commitments to reducing socially created inequalities. However, an inequalities perspective has only begun to emerge in relation to child protection, and child welfare services more widely. The purpose of this paper is to chart evidence of these green shoots of a new policy direction which focusses on two aspects: equalising service provision and outcomes for looked after children.Design/methodology/approachThe paper provides an analysis of trends in policies as expressed in official documents, research studies and policy statements.FindingsThe paper outlines the argument for a more comprehensive approach to addressing inequalities in child protection and child welfare services, and concludes by suggesting some implications for policy and practice.Originality/valueThe paper develops the concept of an inequalities perspective in child protection and outlines key implications.
Outcomes in Children’s Social Care
Authors: Forrester Donald 
Published: September 2017

PurposeThere are often calls for more focus on outcomes in Children’s Social Care yet there is little consensus on what these outcomes should be. Key challenges include who should decide what outcomes should be measured and the sheer range of issues that social workers deal with. The purpose of this paper is to provide a reflective account of approaches to measuring outcomes that the author has used in recent studies in order to illustrate the complexity involved in understanding what the purpose of Children’s Social Care is and therefore how outcomes might be measured.Design/methodology/approachA review of and reflection on lessons from recent research studies carried out by the author and colleagues.FindingsThe results are used to illustrate and support an argument that Children’s Social Care performs multiple functions and that this has implications for thinking about outcomes. Helping children and parents is one element of the work, but assessing risk across large numbers of referrals and identifying those that require involvement is equally important. Furthermore, the social work role requires complex considerations around liberty and the rights of parents and children. One consequence of this is that the quality of the service provided is important in its own right.Research limitations/implicationsIt is suggested that the evaluation of Children’s Social Care involves four types of outcomes: measures of the quality of the service provided; assessment of whether the “right” families are being worked with; client-defined measures of change; and the development of appropriate standardised instruments. Examples of approaches in each area are discussed.Practical implicationsThe theoretical considerations suggest that we need to have a multi-dimensional approach to evaluating, inspecting and leading Children’s Social Care services. In particular, the importance of the quality of delivery and appropriate targeting of the service are emphasised, as well as considering various approaches to measuring outcomes.Originality/valueThe paper proposes a combination of qualitative and quantitative measures of process, assessment and outcomes for evaluating outcomes in Children’s Social Care.
People and systems: reflections on the development of social work for children
Authors: Little Michael 
Published: September 2017

Purpose
The purpose of this paper is to explore the aspects of social work for children, primarily in England.

Design/methodology/approach
It is based on reflections on research undertaken by the author prior to 1995 and after 2015.

Findings
The paper explores the interaction between people – effective leaders and practitioners – and systems.

Research limitations/implications
It is an opinion piece, and does not present findings from a single study.

Practical implications
It urges systems that do not restrict the capability of practitioners.

Social implications
The value of social work services at times of significant social disadvantage demands strong public policy attention.

Originality/value
The study draws on several research and case studies in over 20 English local authorities
Characteristics of knowledge, people engaged in knowledge transfer and knowledge stickiness: evidence from Chinese R&D team
Authors: Huan Huang , Yongyuan Ma , Sheng Zhang , Qinchao Dou 
Published: September 2017

PurposeThe aim of this study is to provide some important insights for knowledge stickiness from the perspective of the characteristic of knowledge and the people engaged in the knowledge transfer. It proposes an empirical model about factors that influence knowledge stickiness.Design/methodology/approachBased on knowledge-based view (KBV), this paper systematically elaborated the research model, and then conducted a survey to test the hypotheses. Data were collected by face-to-face interviews in R&D team of knowledge-intensive firms in China. The empirical results generally support the proposed hypotheses.FindingsThe paper provides empirical insights about how the knowledge transfer willingness, transfer ability, knowledge residence, knowledge articulability and absorption ability affect the knowledge stickiness in the process of knowledge transfer in R&D team.Research limitations/implicationsThis paper provides guidelines about how firms should optimally respond to knowledge stickiness in knowledge transfer process practically.Practical implicationsThe proposed framework helps to understand what factors impact knowledge stickiness in R&D teams. Furthermore, the research also provides guidelines about how firms should optimally respond to knowledge stickiness in knowledge transfer process practically from both aspects of characteristics of knowledge itself and people involved in knowledge transfer.Originality/valueThis study, grounded on KBV, constructs a countermeasure model of weakening knowledge stickiness, which contributes to an understanding of factors leading to the success or failure of knowledge transfer. It eventually theoretically extends the KBV of the firm and commits to improve the efficiency and effectiveness of knowledge transfer practically.
Towards an integrated framework of intrinsic motivators, extrinsic motivators and knowledge sharing
Authors: Law Kuok Kei , Chan Andrew , Ozer Muammer 
Published: September 2017

Purpose
This paper aims to develop an integrated framework to demonstrate the individual and combined effects of intrinsic and extrinsic motivators on two forms of knowledge sharing behaviors – in-depth knowledge sharing and routinized knowledge sharing.

Design/methodology/approach
A range of work on the use of intrinsic and extrinsic motivators and the differential degrees of costs and risks involved in the two forms of knowledge sharing is being reviewed with the aim to locate gaps and problems arising from propositions of different scholars. An integrated framework is then proposed to connect different schools of thoughts into a single, unifying framework.

Findings
Knowledge sharing behaviors among employees are subject to both attractive and distractive forces. Intrinsic and extrinsic motivators might interact positively or negatively depending on the type of extrinsic motivator and the form of knowledge sharing. While enhancing the intrinsic enjoyment of employees along with outcome-based extrinsic motivators can promote in-depth knowledge sharing, the use of behavior-based extrinsic motivators is more appropriate for fostering routinized knowledge sharing.

Research limitations/implications
This paper mainly focuses on the sharing of knowledge without examining the receiver side in knowledge sharing. Also, the use of punitive means by superiors in encouraging knowledge sharing is not discussed in the framework. Future research can also add into the authors’ integrated framework the effects of personal traits in knowledge sharing.

Originality/value
This paper narrows the gap between existing theories on the use of extrinsic and intrinsic motivators and offers an integrated theoretical framework for those interested in examining the inter-relationship among intrinsic motivators, extrinsic motivators and knowledge sharing behaviors.
Managing knowledge in open innovation processes: an intellectual property perspective
Authors: Bican Peter M. , Guderian Carsten C. , Ringbeck Anne 
Published: September 2017

Purpose
As firms turn their innovation activities toward collaborating with external partners, they face additional challenges in managing their knowledge. While different modes of intellectual property right regimes are applied in closed innovation systems, there seems to be tension between the concepts of “open innovation” and “intellectual property rights”. The purpose of this paper is to investigate how firms best manage knowledge via intellectual property rights in open innovation processes.

Design/methodology/approach
Following a mixed methods approach, the authors review relevant literature at the intersection of knowledge management, intellectual property rights, strategic management of intellectual property rights and the open innovation process. The authors identify success drivers through the lenses of – but not limited to – intellectual property rights and classify them in five distinct groups. Expending the view on open innovation beyond its modus operandi, the authors develop the Open Innovation Life Cycle, covering three stages and three levels of the open innovation process. The authors apply their findings to a case study in the pharmaceutical industry.

Findings
The authors provide four key contributions. First, existing literature yields inconclusive results concerning the enabling or disabling function of intellectual property rights in open innovation processes, but the majority of scholars detect an ambivalent relation. Second, they identify and classify success drivers of successful knowledge management via intellectual property rights in open innovation processes. Third, they advance literature on open innovation beyond its modus operandi to include three stages and three levels. Fourth, they test their findings to a case study and show how management leverages knowledge by properly using intellectual property rights in open innovation.

Practical implications
The findings support firms in managing knowledge via intellectual property rights in open innovation processes. Management should account for the peculiarities of open innovation preparation and open innovation termination to prevent unintentional knowledge drain.

Originality/value
This is one of the first studies to view open innovation as a process beyond its modus operandi by considering the preparations for and termination of open innovation activities. It also addresses the levels involved in managing knowledge via intellectual property rights in open innovation from individual (personal) to project and firm level.
Implementing open innovation: conceptual design of an integrated ICT platform
Authors: Aloini Davide , Farina Giulia , Lazzarotti Valentina , Pellegrini Luisa 
Published: September 2017

Purpose
The aim of this paper is to develop the conceptual design of an information and communication technologies (ICT) platform supporting the inbound open innovation (OI) process within the technological developments business unit of Leonardo Defence Systems.

Design/methodology/approach
After a preliminary phase concerning the context analysis, methodology includes three main steps: conceptualization of functions; preliminary design; and conceptual design of the system/SW architecture. In each of these phases, the authors tried to merge evidence from the scientific literature with empirical insight emerging from the field.

Findings
Results report the conceptual design proposal for an integrated ICT platform supporting the OI. It includes the conceptualization of main functions, the preliminary design deriving from use cases and the proposal for the overall system architecture and data model.

Research limitations/implications
The research focuses only on the conceptual design phase; at this stage, the platform has not been still implemented or tested. Also, generalizability concerns may arise from the single-application context.

Practical implications
The outcoming conceptual design can be useful for firms that open their boundaries to external partners, as well as for software developers which could draw on it. Firms approaching similar OI challenges can re-contextualize the platform to their own setting.

Originality/value
Originality of this research relies on the attempt to show how ICT can support firms in their OI processes and, secondly, to support firms aiming to create a positive environment that encourages people at leveraging existing external technological opportunities and sources of knowledge. In so doing, a systematic design approach to the definition of the conceptual proposal is also pursued.
Gender and leadership aspiration: the impact of organizational identification
Authors: Fritz Claudia , van Knippenberg Daan 
Published: September 2017

PurposeAlthough nowadays more women occupy leadership roles, they still are a minority. Because aspiration is a precursor of advancement, examining conditions fostering female leadership aspiration is important. A neglected perspective is the impact of organizational identification. Identification can be argued to foster leadership aspiration because the essence of leadership is the pursuit of collective interests, and identification motivates such pursuits. The paper aims to discuss these issues.Design/methodology/approachA cross-sectional survey design with ann=400 fulltime employed men and women, working for various organizations was selected.FindingsThe initial prediction was that identification is more important to women’s leadership aspiration to the extent that gender is associated with communal orientation, because women tend to have stronger communal orientation with associated greater affiliation needs, and organizational identification can be expected to cater to those needs. The communal orientation by organizational identification interactive influence on leadership aspiration was supported. Also, the indirect effect of gender on leadership aspiration via this interactive influence of communal orientation and organizational identification was supported.Research limitations/implicationsDue to the selected survey approach the data are correlational and as a result no reference to matters of causality can be made. Thus (field) experimental data is needed to confirm these findings.Practical implicationsWithin the paper the discussion focuses on the importance of creating an environment that is more conducive to organizational identification and as such speaks to the communal orientation – being more pronounced among women – to act in favor of the organization by aspiring leadership positions.Originality/valueThe presented results depict an important step toward understanding how organizational identification and communal orientation interact and how they interact with women’s leadership aspiration.