bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models
Authors: Leffler Abba E. , Kuryatov Alexander , Zebroski Henry A. , Powell Susan R. , Filipenko Petr , Hussein Adel K. , Gorson Juliette , Heizmann Anna , Lyskov Sergey , Tsien Richard W. , Poget Sébastien F. , Nicke Annette , Lindstrom Jon , Rudy Bernardo , Bonneau Richard , Holford Mandë 
Published: September 2017

Significance
Predicting how conotoxins bind to nicotinic acetylcholine receptors (nAChRs) is hard. Not only are these venom-derived peptides large, but the structures of many nAChRs are unknown. In response, we developed an ensemble-docking algorithm named ToxDock. We used ToxDock to reliably dock the conotoxin α-GID to a homology model of the α4β2 nAChR, a main nAChR in the brain and target for nicotine addiction therapeutics. A virtual screen with ToxDock identified four α-GID analogs and, based on experimental evidence, correctly predicted their activity at the α4β2 nAChR in all cases. More screening showed that two of these analogs have substantially reduced antagonism at the human α7 nAChR, a key step in optimizing α-GID into a tool for studying brain nAChRs.
Female exogamy and gene pool diversification at the transition from the Final Neolithic to the Early Bronze Age in central Europe
Authors: Knipper Corina , Mittnik Alissa , Massy Ken , Kociumaka Catharina , Kucukkalipci Isil , Maus Michael , Wittenborn Fabian , Metz Stephanie E. , Staskiewicz Anja , Krause Johannes , Stockhammer Philipp W. 
Published: September 2017

SignificancePaleogenetic and isotope data from human remains shed new light on residential rules revealing patrilocality and high female mobility in European prehistory. We show the crucial role of this institution and its impact on the transformation of population compositions over several hundred years. Evidence for an epoch-transgressing maternal relationship between two individuals demonstrates long-debated population continuity from the central European Neolithic to the Bronze Age. We demonstrate that a simple notion of “migration” cannot explain the complex human mobility of third millennium BCE societies in Eurasia. On the contrary, it appears that part of what archaeologists understand as migration is the result of large-scale institutionalized and possibly sex- and age-related individual mobility.
Identification of individuals by trait prediction using whole-genome sequencing data
Authors: Lippert Christoph , Sabatini Riccardo , Maher M. Cyrus , Kang Eun Yong , Lee Seunghak , Arikan Okan , Harley Alena , Bernal Axel , Garst Peter , Lavrenko Victor , Yocum Ken , Wong Theodore , Zhu Mingfu , Yang Wen-Yun , Chang Chris , Lu Tim , Lee Charlie W. H. , Hicks Barry , Ramakrishnan Smriti , Tang Haibao , Xie Chao , Piper Jason , Brewerton Suzanne , Turpaz Yaron , Telenti Amalio , Roby Rhonda K. , Och Franz J. , Venter J. Craig 
Published: September 2017

Significance
By associating deidentified genomic data with phenotypic measurements of the contributor, this work challenges current conceptions of genomic privacy. It has significant ethical and legal implications on personal privacy, the adequacy of informed consent, the viability and value of deidentification of data, the potential for police profiling, and more. We invite commentary and deliberation on the implications of these findings for research in genomics, investigatory practices, and the broader legal and ethical implications for society. Although some scholars and commentators have addressed the implications of DNA phenotyping, this work suggests that a deeper analysis is warranted.
Perceived Cognitive Deficits in a Sample of Persons Living With Multiple Sclerosis
Authors: Henneghan Ashley , Stuifbergen Alexa , Becker Heather , Kullberg Vicki , Gloris Nicole 
Published: September 2017

ABSTRACT

Purpose: The aims of this study were to describe the nature and diversity of perceived cognitive deficits using the Perceived Deficits Questionnaire (PDQ), to assess the reliability of the PDQ, and to explore self-reported predictors of PDQ scores in a large community-based sample of persons with multiple sclerosis (MS). Materials and Methods: Persons with MS enrolled in a randomized controlled trial provided demographic data and completed the PDQ along with measures of cognitive and memory strategies, cognitive abilities, self-efficacy, and depressive symptoms and neuropsychological tests. Results: Most of the 183 participants were non-Hispanic white women, approximately 49 years old, and diagnosed with MS 12.5 years prior. The most frequent cognitive complaints regarded trouble remembering telephone numbers, mind drifting, and forgetting why one came into a room. The PDQ scores were significantly related to self-rated cognitive abilities, depressive symptoms, self-efficacy, and use of cognitive strategies, but not to scores on neuropsychological performance tests. When controlling for other variables, self-rated cognitive abilities was the strongest, significant predictor of perceived cognitive deficits. Conclusion: Persons with MS most frequently experience deficits related to short-term memory and attention. The PDQ total is a reliable measure of perceived cognitive deficits in persons with MS, is feasible for use by nurses in clinical settings—can be administered in approximately 5 minutes, and is easily scored.
Efficacy and tolerability of culture-guided treatment for Helicobacter pylori infection
Authors: Costa Samuel , Soares João-Bruno , Gonçalves Raquel 
Published: September 2017

Objective
The aim of this study was to evaluate the efficacy/tolerability of a culture-guided approach in the eradication of Helicobacter pylori and identify factors associated with antibiotic resistance/treatment failure.

Patients and methods
This retrospective single-center study included patients who underwent culture-guided treatment for H. pylori infection, after two ineffective eradication attempts, between October 2012 and December 2016. We assessed the following demographic and clinical data of the patients: sex, age, BMI, alcohol and tobacco consumption, history of dyspepsia, peptic ulceration and first-degree relatives with gastric cancer, antibiotic susceptibility results, treatment composition, tolerability, and success. The treatment success was confirmed by a monoclonal stool antigen test.

Results
Culture-guided treatment was performed in 42 patients (57% women, mean age±SD: 48.9±11.4 years). The rates of antibiotic resistance were as follows: clarithromycin 86%, metronidazole 67%; levofloxacin 52%, tetracycline 2%, and amoxicillin and rifampicin 0%. Double resistance to clarithromycin and metronidazole was found in 59.5% of the patients. Most patients showed resistance to less than three antibiotics, but 31% were resistant to three or more. Intention-to-treat and per-protocol eradication rates were 59.5 and 61.5%. Adverse events occurred in 15 (35.7%) patients, but only two (4.8%) patients did not complete treatment because of adverse events. Only age more than 50 years was associated with resistance to three or more antibiotics. Having a first-degree relative with gastric cancer was associated with treatment failure and having a BMI of at least 25 kg/m2 protected from failure.

Conclusion
Third-line culture-guided treatment often fails to eradicate H. pylori infection. We need to find factors other than in-vitro antibiotic resistance to explain these suboptimal results.
Hematopoietic cell transplantation for aplastic anemia
Authors: Kumar Rajat , Bonfim Carmem , George Biju 
Published: September 2017

Purpose of review
Improvements in allogeneic hematopoietic cell transplantation (HCT) with better donor selection, conditioning regimens and graft vs. host disease prophylaxis make it reasonable to move HCT earlier in the algorithm for management of severe aplastic anemia (SAA). Recent progress in transplantation is reviewed whereas issues related to developing countries are also addressed.

Recent findings
Multiple research centers are reporting on clonality, mutations and telomere disorders in SAA, which may help to choose the most appropriate therapy upfront. Eltrombopag, in combination with immunosuppressive therapy (IST), has shown remarkable improvement over historical IST, and long-term follow-up is awaited. In younger patients and in experienced centers, matched unrelated-donor (MUD) and related haploidentical transplants (haplo-HCT) are being reported with survival approaching that seen with sibling transplants. Literature from resource-limited countries highlight the need to modify guidelines to make them affordable and cost-effective. Bone marrow remains the graft source of choice; peripheral blood stem cells may be acceptable in special circumstances in resource-constrained countries.

Summary
The potential of novel research findings and new therapeutic trials should be maximized by validation in different centers, countries and patient populations to provide personalized care to patients with aplastic anemia.
Computerised Interpretation of Fetal Heart Rate During Labour (INFANT): A Randomised Controlled Trial
Authors: Brocklehurst Peter , Field David , Greene Keith , Juszczak Ed , Keith Robert , Kenyon Sara , Linsell Louise , Mabey Christopher , Newburn Mary , Plachcinski Rachel , Quigley Maria , Schroeder Elizabeth , Steer Philip 
Published: September 2017

(Abstracted from Lancet 2017;389:1719–1729)
INFANT is a decision-support software that assesses fetal heart rate quality and contraction patterns alongside the Guardian electronic information capture system. INFANT color codes fetal heart rate patterns based on abnormalities (mild, moderate, severe), but does not make recommendations for clinical actions.
GATA3 Immunohistochemical Staining in Hodgkin Lymphoma: Diagnostic Utility in Differentiating Classic Hodgkin Lymphoma From Nodular Lymphocyte Predominant Hodgkin Lymphoma and Other Mimicking Entities
Authors: Kezlarian Brie , Alhyari Mohammad , Venkataraman Girish , Karner Kristin , Inamdar Kedar V. , Menon Madhu P. 
Published: September 2017

Background:
Classic Hodgkin lymphoma (CHL) and nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) are clinically distinct entities, with different prognostic and treatment implications. In addition, several large B-cell lymphomas and some T-cell lymphomas can mimic CHL. Differentiating these entities from CHL is crucial for ensuring appropriate therapy. GATA3 is a T-cell transcription factor involved in T-cell maturation and has been previously shown to be overexpressed in CHL cells via gene expression profiling. We investigated the utility of GATA3 immunostain in differentiating CHL from NLPHL and other mimicking entities.

Materials and Methods:
We accrued 17 NLPHLs, 49 CHLs [23 nodular sclerosis (NS), 3 syncytial variants, 3 lymphocyte rich and 13 mixed cellularity types], 4 primary mediastinal large B-cell lymphomas (PMBLs), 2 Epstein-Barr virus (EBV) positive diffuse large B-cell lymphomas (DLBCLs) (EBV+LBCLs), 2 T-cell/histiocyte-rich large B-cell lymphomas (TCHRBCLs), 1 gray zone lymphoma, and 2 tissue microarrays consisting of 72 DLBCLs. One slide from each was stained with GATA3 and percent positive tumor cells and intensity of nuclear expression was semiquantitatively graded independently by 2 board certified hematopathologists.

Results:
GATA3 was positive in 80% of CHLs. Both percent positivity and intensity of staining varied greatly. Syncytial variant of NS subtype showed the highest positivity rate (3/3; 100%), followed by NS (20/23; 87%), mixed cellularity (9/13; 70%), and lymphocyte rich (2/3; 67%). GATA3 was negative in all NLPHLs, EBV+LBCLs, TCRBCLs, and DLBCLs stained. The single gray zone lymphoma and 3/4 PMBLs were positive.

Conclusions:
Nuclear expression of GATA3 can be used to delineate CHL from NLPHL. GATA3 positivity effectively excludes NLPHL with 100% negative predictive value. However, as 20% of CHL can be negative for GATA3, CHL cannot be ruled out with negative GATA3. Additional findings include GATA3 positivity among PMBLs, whereas all 72 DLBCLs were negative for GATA3. This finding further highlights similarities between CHL and PMBL.
A Neuroeconomic Framework for Creative Cognition
Authors: Lin Hause , Vartanian Oshin 
Published: September 2017

AbstractNeuroeconomics is the study of the neurobiological bases of subjective preferences and choices. We present a novel framework that synthesizes findings from the literatures on neuroeconomics and creativity to provide a neurobiological description of creative cognition. It proposes that value-based decision-making processes and activity in the locus coeruleus-norepinephrine (LC-NE) neuromodulatory system underlie creative cognition, as well as the large-scale brain network dynamics shown to be associated with creativity. This framework allows us to re-conceptualize creative cognition as driven by value-based decision making, in the process providing several falsifiable hypotheses that can further our understanding of creativity, decision making, and brain network dynamics.
“[T]here are known knowns … things we know that we know”
Authors: de Loo Ivo , Lowe Alan 
Published: September 2017

Purpose
The starting point for this paper is that the researcher is intimately bound up in all aspects of the research process. This idea of what is a critical aspect of much interpretive methodology has been challenged by some proponents of the interpretive accounting research (IAR) project. The authors suggest that adopting some of the views expounded in the IAR project may lead to the accounting research community becoming isolated from other interpretive methodology inspired disciplines. The paper aims to discuss these issues.

Design/methodology/approach
Currently popular views on IAR are informed by selective theoretical insights from interpretive sociology. The authors argue that these insights cannot provide a general frame with which to encapsulate accounting research that may be reasonably termed “interpretive.”

Findings
The authors’ reading of the literature suggests that the some of the IAR literature exhibits: a tendency to routinely make overly specific claims for what it is possible for interpretive research to achieve; the promotion of a somewhat reductionist view of what the bounds of interpretive research are. The authors suggest that these tendencies detract from the strengths of (adopting a broad view of) IAR.

Research limitations/implications
In expressing the authors’ concerns, the authors do not wish to make an exclusive argument for what IAR is and is not. This would not be in line with writing an interpretive paper. While the authors do not eschew the possibility of a limited building of knowledge by applying interpretive methodological stances neither do the authors see such activity as a central plank of interpretive research.

Practical implications
The authors believe that positivistic commentaries on qualitative enquiry should not be taken as exemplary of interpretive research (in accounting – or elsewhere). The authors feel that IAR needs to be more open to an array of subjectivist motivations, if it is to provide useful critique of the nature of day-to-day accounting practice.

Originality/value
The authors seek to go beyond the rather unhelpful debate about whether IAR should be seen to possess both objective and subjective elements. The authors argue that IAR suffers more from a lack of engagement and debate than it faces dangers from areas of interpretive methodology that adopt positions considered to be too subjectivist.
Effect of TRIZ on enhancing employees’ creativity and innovation
Authors: Jafari Mostafa , Zarghami Hamid Reza 
Published: September 2017

PurposeRegarding the important roles of creativity and innovation for accomplishing innovative missions in aerospace industries, this study aims to explore the impact of a three-month TRIZ (an engineering problem-solving toolkit) training workshop on enhancing three important creativity- and innovation-related characteristics of employees in Iran aerospace industries.Design/methodology/approachA three-month TRIZ educational program was run. Three standard questionnaires were used for assessing creative thinking (CT), need for cognition (NFC) and interest in work innovation (IWI). From different scientific sectors of aerospace industries, 290 participants took part in completing pre- and post-test questionnaires. The collected data were analyzed by the related statistical methods (the sign test, correlation analysis and descriptive statistics).FindingsThe results indicate that the TRIZ training workshop directly enhanced CT, NFC and IWI scores, and that there is a statistically significant positive correlation between these characteristics. Also, the results of the correlation analysis of these variables and the demographic features of the participants shed light on interesting facts that can be used for decision makers and researchers of aerospace industries.Research limitations/implicationsThis study opens a new way for further research in the analysis of the impact of problem-solving techniques on improving creativity and innovation in aerospace and other high-tech industries.Originality/valueThis paper may be of high value to researchers in creativity and innovation fields in the high-tech industries, including the aerospace industry. This study further facilitates decision-making by enhancing inventive problem solving in these industries. It gives valuable information and guidelines that hopefully will help managers to consider the important issues during TRIZ toolkit establishment in their organizations.
Aerodynamic performance improvement of a canard control missile
Authors: Tahani M. , Masdari M. , Kazemi M. 
Published: September 2017

Purpose
This paper aims to analyze the influence of the changings in geometrical parameters on the aerodynamic performance of the control canard projectiles.

Design/methodology/approach
Because of the mentioned point, the range of projectiles increment has a considerable importance, and the design algorithm of a control canard projectile was first written. Then, were studied the effects of canard geometric parameters such as aspect ratio, taper ratio and deflectable nose on lift to drag coefficient ratio, static margin based on the slender body theory and cross section flow.

Findings
The code results show that aspect ratio increment, results in an increase in lift-to-drag ratio of the missile, but increase in canard taper ratio results in increasing of lift-to-drag ratio at 1° angle of attack, while during increasing the canard taper ratio up to 0.67 at 4° angle of attack, lift to drag first reaches to maximum and then decreases. Also, static margin decreases with canard taper ratio and aspect ratio increment. The developed results for this type of missile were compared with same experimental and computational fluid dynamic (CFD) results and appreciated agreement with other results at angles of attack between 0° and 6°.

Practical implications
To design a control canard missile, the effect of each geometric parameter of canard needs to be estimated. For this purpose, the suitable algorithm is used. In this paper, the effects of canard geometric parameters, such as aspect ratio, taper ratio and deflectable nose on lift-to-drag coefficient ratio and static margin, were studied with help of the slender body theory and cross-section flow.

Originality/value
The contribution of this paper is to predict the aerodynamic characteristics for the control canard missile. In this study, the effect of the design parameter on aerodynamic characteristics can be estimated, and the effect of geometrical characteristics has been analyzed with a suitable algorithm. Also, the best lift-to-drag coefficient for the NASA Tandem Control Missile at Mach 1.75 was selected at various angles of attack. The developed results for this type of missile were compared with same experimental and CFD results.
Aircraft maintenance checks using critical chain project path
Authors: Kulkarni Anand , Yadav Devinder Kumar , Nikraz Hamid 
Published: September 2017

Purpose
Aircraft operators incur significant costs when an aircraft is taken out of service for maintenance. The purpose of this paper is to present a method for reducing time duration of aircraft maintenance checks using critical chain project management (CCPM) principle.

Design/methodology/approach
A case study of a typical heavy maintenance check performed on an Airbus 320 aircraft is undertaken for the analysis. The critical chain method is applied to develop a plan with a reduced duration and a survey and field observations to validate the findings have also been carried out as a part of this paper.

Findings
The paper compares the traditional project management method with CCPM in view of reducing the aircraft down time duration for maintenance. This paper repositions buffers and other techniques to shorten the chain path and a reduction in the total duration of the project by five days is achieved.

Research limitations/implications
It is argued that the application of CCPM principle can reduce the duration of an aircraft maintenance check, but this paper is done in a single project situation focusing on project planning and execution. Therefore, additional study may be required to examine other issues.

Originality/value
Cost of the maintenance is second highest expenditure factor for an airline operator. Therefore, it is necessary to drive the maintenance cost down. The paper demonstrates that the duration of a maintenance check can be reduced by 8.9 per cent using the method suggested in this paper.
Modeling of anisotropic magnetostriction under alternating magnetization based on neural network-FFT model
Authors: Zhang Yanli , Zhou Hang , Zhang Dianhai , Ren Ziyan , Xie Dexin 
Published: September 2017

Purpose
This paper aims to investigate the magnetostrictive phenomenon in a single electrical steel sheet, which may cause vibration and noise in the cores of transformers and induction motors. A measurement system of magnetostriction is created and the principal strain of magnetostriction is modeled. Furthermore, the magnetostriction property along arbitrary alternating magnetization directions is modeled.

Design/methodology/approach
A measurement system with a triaxial strain gauge is developed to obtain the magnetostrictive waveform, and the principal strain is computed in terms of the in-plane strain formula. A three-layer feed-forward neural network model is proposed to model the measured magnetostriction property of the electrical steel sheet.

Findings
The principal strain of magnetostriction of the non-oriented electrical steel has strong anisotropy. The proposed estimation model can be effectively used to model the anisotropic magnetostriction with an acceptable prediction time.

Originality/value
This paper develops the neural network combined with fast Fourier transform (FFT) to model the principal strain property of magnetostriction under alternating magnetizations, and its validation has been verified.