bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete atrioventricular block in acute coronary syndrome: prevalence, characterisation and implication on outcome
Authors: Aguiar Rosa Silvia , Timóteo Ana Teresa , Ferreira Lurdes , Carvalho Ramiro , Oliveira Mario , Cunha Pedro , Viveiros Monteiro André , Portugal Guilherme , Almeida Morais Luis , Daniel Pedro , Cruz Ferreira Rui 
Published: June 2017

Purpose: The aim was to characterise acute coronary syndrome patients with complete atrioventricular block and to assess the effect on outcome. Methods: Patients admitted with acute coronary syndrome were divided according to the presence of complete atrioventricular block: group 1, with complete atrioventricular block; group 2, without complete atrioventricular block. Clinical, electrocardiographic and echocardiographic characteristics and prognosis during one year follow-up were compared between the groups. Results: Among 4799 acute coronary syndrome patients admitted during the study period, 91 (1.9%) presented with complete atrioventricular block. At presentation, group 1 patients presented with lower systolic blood pressure, higher Killip class and incidence of syncope. In group 1, 86.8% presented with ST-segment elevation myocardial infarction (STEMI), and inferior STEMI was verified in 79.1% of patients in group 1 compared with 21.9% in group 2 ( P<0.001). Right ventricular myocardial infarction was more frequent in group 1 (3.3% vs. 0.2%; P<0.001). Among patients who underwent fibrinolysis complete atrioventricular block was observed in 7.3% in contrast to 2.5% in patients submitted to primary percutaneous coronary intervention ( P<0.001). During hospitalisation group 1 had worse outcomes, with a higher incidence of cardiogenic shock (33.0% vs. 4.5%; P<0.001), ventricular arrhythmias (17.6% vs. 3.6%; P<0.001) and the need for invasive mechanical ventilation (25.3% vs. 5.1%; P<0.001). After a propensity score analysis, in a multivariate regression model, complete atrioventricular block was an independent predictor of hospital mortality (odds ratio 3.671; P=0.045). There was no significant difference in mortality at one-year follow-up between the study groups. Conclusion: Complete atrioventricular block conferred a worse outcome during hospitalisation, including a higher incidence of cardiogenic shock, ventricular arrhythmias and death.
Relation of subclinical serum creatinine elevation to adverse in-hospital outcomes among myocardial infarction patients
Authors: Margolis Gilad , Gal-Oz Amir , Khoury Shafik , Keren Gad , Shacham Yacov 
Published: June 2017

Background: Acute kidney injury is associated with adverse outcomes after acute ST elevation myocardial infarction (STEMI). It remains unclear, however, whether subclinical increase in serum creatinine that does not reach the consensus criteria for acute kidney injury is also related to adverse outcomes in STEMI patients undergoing primary percutaneous coronary intervention. Methods: We conducted a retrospective study of 1897 consecutive STEMI patients between January 2008 and May 2016 who underwent primary percutaneous coronary intervention, and in whom acute kidney injury was not diagnosed throughout hospitalization. We investigated the incidence of subclinical acute kidney injury (defined as serum creatinine increase of ≥ 0.1 and < 0.3 mg/dl) and its relation to a composite end point of adverse in hospital outcomes. Results: Subclinical acute kidney injury was detected in 321 patients (17%). Patients with subclinical acute kidney injury had increased rate of the composite end point of adverse in-hospital events (20.3% vs. 9.7%, p<0.001), a finding which was independent of baseline renal function. Individual components of this end point (occurrence of heart failure, atrial fibrillation, need for mechanical ventilation and in-hospital mortality) were all significantly higher among patients with subclinical acute kidney injury ( p< 0.05 for all). In a multivariable regression model subclinical acute kidney injury was independently associated with higher risk for adverse in-hospital events (odds ratio 1.92.6, 95% confidence interval: 1.23–2.97, p=0.004). Conclusions: Among STEMI patients treated with primary percutaneous coronary intervention, small, subclinical elevations of serum creatinine, while not fulfilling the consensus criteria for acute kidney injury, may serve as a significant biomarker for adverse outcomes.
Tubularized incised plate urethroplasty for distal and midpenile hypospadias reoperation: A single institute experience
Authors: Salih Elsayed M , Elemam Abdelbaset , Elfeky Mohamed , Abdrabuh Abdrabuh M , Galal Hussein A 
Published: June 2017

Objective: Our study aimed to evaluate our experience in tubularized incised plate urethroplasty in distal and midpenile hypospadias reoperation. Patients and methods: This was a retrospective study in which we reviewed the medical records of 56 patients who underwent tubularized incised plate urethroplasty in distal and midpenile hypospadias reoperation. Tubularized incised plate urethroplasty was performed using a surgical technique like the primary tubularized incised plate repair based on the Snodgrass’s method. We recorded complications and functional outcomes of redo procedures. Results: We reviewed 56 patients who ranged in age from 2–16 years (mean 7.02±3.8 years). The overall complication rate was 33.9% ( n=19). Eight patients (14.3%) had fistula, six had meatal stenosis (10.7%), four had dehiscence (7.1%), and one had neourethral stenosis (1.8%). The complications occurred in 13 of mid-penile cases representing 50% of mid-penile cases but occurred in six cases of distal-penile cases (20%). The success rate of tubularized incised plate urethroplasty reoperation was 94.6% after repair of fistula and meatal stenosis by simple closure of fistula and meatoplasty. Conclusion: Tubularized incised plate urethroplasty is a safe and effective alternative procedure for hypospadias reoperations. The outcome is favorable if the urethral plate has no scars and with distal meatal location. The complication rate increases if the third redo is done and with midpenile meatal location.
Study of Cardiovascular Outcomes in Renal Transplantation: A Prospective, Multicenter Study to Determine the Incidence of Cardiovascular Events in Renal Transplant Recipients in Ontario, Canada
Authors: Ribic Christine M. , Holland David , Howell John , Jevnikar Anthony , Kim S. Joseph , Knoll Greg , Lee Brenda , Zaltzman Jeffrey , Gangji Azim S. 
Published: June 2017

Background: Renal transplant recipients (RTRs) are at significantly higher risk for morbidity and mortality compared with the general population, largely attributed to cardiovascular disease (CVD). Previous estimates of CVD events have come from health care databases and retrospective studies. Objective: The objective of this study was to prospectively determine the prevalence of risk factors and incidence of CVD events in a Canadian cohort of RTRs. Design: Study of Cardiovascular Outcomes in Renal Transplantation (SCORe) was a prospective, longitudinal, multicenter observational study. Setting: Adult RTRs were recruited from 6 participating transplant sites in Ontario, Canada. Patients: Eligible patients were those receiving a living or deceased donor renal transplant. Patients who received simultaneous transplant of any other organ were excluded. Measurements: Primary outcomes included myocardial infarction (MI) defined by American College of Cardiology (ACC-MI) criteria, and major adverse cardiac events (MACE), defined as cardiovascular (CV) death, ACC-MI, coronary revascularization, and nonhemorrhagic stroke. CV events were adjudicated by a single, independent cardiologist. Methods: CV and transplant-specific risk factors that predict MACE and ACC-MI were identified by stepwise regression analysis using the Cox proportional hazards model. Results: A total of 1303 patients enrolled across 6 transplant centers were followed for 4.5 ± 1.6 years (mean ± SD). Incidence of MACE was 7.0%, with significant independent predictors/risk factors including age, diabetes, coronary revascularization, nonhemorrhagic stroke, and renal replacement therapy (RRT). ACC-MI incidence was 4.0%, with significant independent predictors/risk factors including age, coronary revascularization, and duration of RRT in excess of the median value (2.91 years). Limitations: Patients were recruited from a single province, so may not reflect the experience of RTRs in other areas of Canada. Conclusions: Using a prospective design and rigorous methodology, this study found that the incidence of CV events after renal transplantation was elevated relative to the general Canadian population and was comparable with that reported in patient registries, thus helping validate the utility of retrospective analysis in this field. SCORe highlights the importance of monitoring RTRs for traditional cardiac and transplant-specific CV risk factors to help prevent CV morbidity and mortality. Further research is needed to investigate a broader range of potential risk factors and their combined effects on incident CV events.
Predictive value of Pirani scoring system for tenotomy in the management of idiopathic clubfoot
Authors: David Badmus Hakeem , Olayinka O Adegbehingbe , Oluwadare Esan , Ayodele Orimolade E , Joseph O Mejabi , Olujide Arije 
Published: June 2017

Purpose: To determine the predictive value of the Pirani scoring system in the need for tenotomy using the Ponseti method for management of idiopathic clubfoot. Method: This is a prospective observational study involving patients less than 2 years of age with idiopathic clubfoot. The consenting parents and institution ethical board approved the study. The relationship between Pirani scores and the need for tenotomy was evaluated using the independent t-test and the binary logistic regression to predict the need for tenotomy. Pearson’s r and Cohen’s κ were used to measure correlation and agreement, respectively, between the predicted and observed values. A receiver operating characteristic curve was used to interpret sensitivity and specificity levels as well as to obtain a cutoff score for predicting the requirement for tenotomy. Results: Eighty-four clubfeet from 50 patients were studied. Thirty-eight feet (45%) had percutaneous tenotomy. The initial total Pirani and hindfoot scores were found to predict the need for tenotomy with the model for prediction being able to predict correctly in 72.6% and 75% of the time, respectively. A higher Pirani score was associated with higher odds of requiring tenotomy (OR = 4.402, p < 0.001) and total Pirani score above the cutoff point of 4.75 predicted the need for tenotomy. Conclusion: The indication for tenotomy appears to be well predicted using the Pirani scoring system with the odds of requiring a tenotomy increasing by more than fourfold for every unit increase in Pirani score.
Does Neuroticism Influence Oral Health–Related QOL in Patients with Removable Partial Dentures?
Authors: Ishida K. , Nogawa T. , Takayama Y. , Saito M. , Yokoyama A. 
Published: June 2017

This prospective cohort study investigated the relationship between patient neuroticism and oral health–related quality of life (OHRQoL) before and after prosthetic treatment as well as changes in OHRQoL—namely, treatment efficacy. Sixty-three patients (23 men and 40 women; mean age 67.2 ± 8.6 years), who were scheduled to receive new removable partial dentures (RPDs), were recruited. OHRQoL was assessed using the Japanese version of the Oral Health Impact Profile (OHIP-J). The Japanese version of the NEO Five-Factor Inventory (NEO-FFI) was used to assess neuroticism. Spearman’s rank correlation coefficient was calculated to determine the association between neuroticism and OHIP-J scores before and after treatment. After stratifying patients according to neuroticism score, the Wilcoxon signed-rank test was used for intragroup comparison of OHIP-J scores before and after treatment. Moreover, logistic regression analysis was used to determine the impact of covariates on treatment efficacy such as age, sex, Eichner classification, neuroticism, changes in maximal occlusal force, and OHIP-J scores before treatment. Statistical analyses showed that higher neuroticism scores were associated with higher total OHIP-J scores before treatment ( r = 0.41, P = 0.001) but were not associated with OHIP-J scores after treatment ( r = 0.07, P = 0.566). When the effect of all independent variables was analyzed in multivariate analysis, neuroticism and OHIP-J scores before treatment affected treatment efficacy. These results suggest that OHRQoL of patients with higher levels of neuroticism was low before prosthetic treatment but significantly improved by oral rehabilitation with RPDs to the same level as patients with lower levels of neuroticism. Knowledge Transfer Statement: The results of this study may change the clinical perception of the effect of prosthetic rehabilitation with removable partial dentures in patients with higher levels of neuroticism. The study concluded that prosthetic rehabilitation could contribute toward satisfaction even in neurotic patients, who are presumed to show less satisfaction with their oral status.
Object play in infants with autism spectrum disorder: A longitudinal retrospective video analysis
Authors: Wilson Kaitlyn P , Carter Mary W , Wiener Heather L , DeRamus Margaret L , Bulluck John C , Watson Linda R , Crais Elizabeth R , Baranek Grace T 
Published: June 2017

Background and aims Early play behaviors may provide important information regarding later-diagnosed developmental delays. Play behaviors of young children with autism spectrum disorder are restricted in diversity, frequency, and complexity. Most autism spectrum disorder research focuses on play in children over 18 months of age. This study examined three groups of infants (later diagnosed with autism spectrum disorder, later diagnosed with other developmental disorders, and typically developing) with the aims of: (1) describing the play behaviors of the three groups of infants at two time points (9–12 months and 15–18 months); (2) examining group differences in four hierarchical levels of play at both time points; (3) comparing groups with respect to the highest level of play achieved; and (4) determining if the highest level of play achieved by infants with autism spectrum disorder and other developmental delays correlated with later developmental outcomes. Methods The current study used longitudinal retrospective video analysis to examine object play behaviors of the three groups of infants (total n = 92) at two time points (time 1: 9–12 months of age, and time 2: 15–18 months of age). Coding of play behaviors was based on existing literature and distribution of data from the current study. Developmental outcomes examined were measured using the Vineland Adaptive Behavior Scales, Childhood Autism Rating Scale, and a non-verbal developmental quotient calculated using visual reception scores from the Mullen Scales for Early Learning. Results Results indicate group differences in play, with infants later diagnosed with autism spectrum disorder showing significantly less sophisticated play than those with typical development. In addition, modest but significant correlations were found between highest level of play achieved at time 1 (9–12 months) and time 2 (15–18 months) and later outcomes for the autism spectrum disorder group. Conclusions and implications Results suggest that examination of infant play behaviors is important for early screening and intervention planning to potentially mitigate effects on later developmental outcomes.
Location of intracerebral haemorrhage predicts haematoma expansion
Authors: Yogendrakumar Vignan , Demchuk Andrew M , Aviv Richard I , Rodriguez-Luna David , Molina Carlos A , Blas Yolanda S , Dzialowski Imanuel , Kobayashi Adam , Boulanger Jean-Martin , Lum Cheemun , Gubitz Gord , Padma Vasantha , Roy Jayanta , Kase Carlos S. , Bhatia Rohit , Hill Michael D , Dowlatshahi Dar 
Published: June 2017

Introduction The role of intracerebral haemorrhage location in haematoma expansion remains unclear. Our objective was to assess the effect of lobar versus non-lobar haemorrhage on haematoma expansion and clinical outcome. Patients and methods We analysed data from the prospective PREDICT study where patients with intracerebral haemorrhage presenting to hospital under 6 h of symptom onset received baseline computed tomography (CT), CT angiogram, 24 h follow-up CT, and 90-day mRS. Intracerebral haemorrhage location was categorised as lobar versus non-lobar, and primary outcomes were significant haematoma expansion (>6 ml) and poor clinical outcome (mRS > 3). Multivariable regression was used to adjust for relevant covariates. The primary analysis population was divided by spot sign status and the effect of haemorrhage location was compared to haematoma expansion in exploratory post hoc analysis. Results Among 302 patients meeting the inclusion criteria, lobar haemorrhage was associated with increased haematoma expansion >6 ml (p = 0.003), poor clinical outcome (p = 0.011) and mortality (p = 0.017). When adjusted for covariates, lobar haemorrhage independently predicted significant haematoma expansion (aOR 2.2 (95% CI: 1.1–4.3), p = 0.021) and poor clinical outcome (aOR 2.6 (95% CI: 1.2–5.6), p = 0.019). Post hoc analysis showed that patients who were spot sign negative had a higher degree of haematoma expansion with baseline lobar haemorrhage (lobar 26% versus deep 11%; p = 0.01). No significant associations were observed in spot-positive patients (lobar 52% versus deep 47%; p = 0.69). Discussion and Conclusion Haematoma expansion is more likely to occur with lobar intracerebral haemorrhage and haemorrhage location is associated with poor clinical outcome. As expansion is a promising therapeutic target, hemorrhage location may be helpful for prognostication and as a selection tool in future ICH clinical trials.
Androgen Receptor Expression in Primary Nonsquamous Cell Rare‐Variant Carcinomas of the Head and Neck
Authors: Rahimi Siavash , Bradley Katherine L. , Akaev Iolia , Marani Carla , Yeoh Chit Cheng , Brennan Peter A. 
Published: June 2017

ObjectiveAndrogen receptor (AR) is a diagnostic immunohistochemical marker for salivary gland duct carcinoma (SDC), but other nonsquamous cell head and neck carcinomas (NSCCs) may also express it. The aim of this preliminary study was to investigate the immunohistochemical expression of AR in rare head and neck NSCCs.Study DesignRetrospective analysis of histologic records.SettingA large community hospital.Subjects and MethodsTwenty‐seven patients with NSCC were selected (21 men, 6 women; average age, 69 years). Exclusion criteria were histologically confirmed primary and metastatic head and neck squamous cell carcinomas and thyroid carcinomas. AR immunohistochemistry was done on formalin‐fixed, paraffin‐embedded tissue blocks.ResultsVariable AR expression was found in 5 of 27 (25%) cases of NSCC. All 7 patients with SDC showed intense and extensive positive immunoreactivity. Of 27 NSCC tumors, 15 (56%) had negative staining.ConclusionIn the head and neck, expression of AR is not limited to SDCs; other NSCCs also express it. When surgery or radiotherapy is not appropriate for recurrent or metastatic head and neck NSCC, palliative chemotherapy offers poor results. Antiandrogen therapy is well tolerated and is much less toxic than chemotherapy. Since androgen deprivation therapy has been used against SDCs, this therapy may theoretically be used in a small subset of head and neck NSCCs.
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell–induced protection of AML
Authors: Karjalainen Riikka , Pemovska Tea , Popa Mihaela , Liu Minxia , Javarappa Komal K. , Majumder Muntasir M. , Yadav Bhagwan , Tamborero David , Tang Jing , Bychkov Dmitrii , Kontro Mika , Parsons Alun , Suvela Minna , Mayoral Safont Mireia , Porkka Kimmo , Aittokallio Tero , Kallioniemi Olli , McCormack Emmet , Gjertsen Bjørn T. , Wennerberg Krister , Knowles Jonathan , Heckman Caroline A. 
Published: June 2017

Key Points
BM stroma-derived conditions protect AML patient cells against topoisomerase II and BCL2 inhibitors, as well as several classes of TKIs. JAK1/2 inhibitor ruxolitinib reverses cytoprotection against BCL2 antagonist venetoclax, suggesting a novel combinatorial treatment.
ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells
Authors: Garrison Brian S. , Rybak Adrian P. , Beerman Isabel , Heesters Balthasar , Mercier Francois E. , Scadden David T. , Bryder David , Baron Roland , Rossi Derrick J. 
Published: June 2017

Key Points
ZFP521 regulates HSC self-renewal and differentiation. ZFP521 facilitates leukemogenesis in an MLL-AF9–mediated leukemia model.
Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients
Authors: Agrawal Anant A. , Seiler Michael , Brinton Lindsey T. , Mantel Rose , Lapalombella Rosa , Woyach Jennifer A. , Johnson Amy J. , Zhu Ping , Warmuth Markus , Yu Lihua , Byrd John C. , Smith Peter G. , Blachly James S. , Buonamici Silvia 
Published: June 2017

Key Points
We identify and characterize novel SF3B1 in-frame deletions in chronic lymphocytic leukemia. These deletions are functionally similar to well-known SF3B1 hotspot mutations and are sensitive to splicing modulation.
Rear-screen and kinesthetic vision 3D manipulator
Authors: Yang Chao-Chung , Kang Shih-Chung Jessy , Yang Hsiang-Wen , Wu Tzong-Hann 
Published: June 2017

Abstract
Background
The effective 3D manipulation, comprehension, and control of 3D objects on computers are well-established lasting problems, which include a display aspect, a control aspect, and a spatial coupling between control input and visual output aspect, which is a debatable issue. Most existing control interfaces are located in front of the display. This requires users to imagine that manipulated objects that are actually behind the display exist in front of the display.

Methods
In this research, a Rear-Screen and Kinesthetic Vision 3D Manipulator is proposed for manipulating models on laptops. In contrast to the front-screen setup of a motion controller, it tracks a user’s hand motion behind screens, coupling the actual interactive space with the perceived visual space. In addition, Kinesthetic Vision provides a dynamic perspective of objects according to a user’s sight, by tracking the position of their head, in order to obtain depth perception using the “motion parallax” effect.

Results
To evaluate the performance of “rear-screen interaction” and Kinesthetic Vision, an experiment was conducted to compare the front-screen setup, the rear-screen setup with Kinesthetic Vision, and the rear-screen setup without it. Subjects were asked to grasp and move a cube from a fixed starting location to a target location in each trial. There were 20 designated target locations scattered in the interactive space. The moving time and distance were recorded during experiments. In each setup, subjects were asked to go through five trial blocks, including 20 trials in each block. The results show that there are significant differences in the moving efficiency by repeated measures ANOVA.

Conclusion
The Rear-Screen and Kinesthetic Vision setup gives rise to better performance, especially in the depth direction of movements, where path length is reduced by 24%.