bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas
Authors: Pilati Camilla , Shinde Jayendra , Alexandrov Ludmil B , Assié Guillaume , André Thierry , Hélias‐Rodzewicz Zofia , Ducoudray Romain , Le Corre Delphine , Zucman‐Rossi Jessica , Emile Jean‐François , Bertherat Jérôme , Letouzé Eric , Laurent‐Puig Pierre 
Published: January 2017

AbstractGermline alterations in DNA repair genes are implicated in cancer predisposition and can result in characteristic mutational signatures. However, specific mutational signatures associated with base excision repair (BER) defects remain to be characterized. Here, by analysing a series of colorectal cancers (CRCs) using exome sequencing, we identified a particular spectrum of somatic mutations characterized by an enrichment of C > A transversions in NpCpA or NpCpT contexts in three tumours from a MUTYH‐associated polyposis (MAP) patient and in two cases harbouring pathogenic germline MUTYH mutations. In two series of adrenocortical carcinomas (ACCs), we identified four tumours with a similar signature also presenting germline MUTYH mutations. Taken together, these findings demonstrate that MUTYH inactivation results in a particular mutational signature, which may serve as a useful marker of BER‐related genomic instability in new cancer types. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Enhanced properties of polyvinyl chloride modified by graphene reinforced thermoplastic polyurethane
Authors: Yang Tao , Wen Jiating , Guan Xiaoyu , Fan Haojun , Chen Yi , Yan Jun 
Published: January 2017

AbstractGraphene sheets with a range of unusual properties and thermoplastic polyurethane (TPU) were combined to modify polyvinyl chloride (PVC), and the enhanced properties such as flexibility, thermal stability and mechanical properties of the PVC were investigated. In order to avoid the C − Cl bonds in PVC being weakened, graphene was incorporated into TPU in the melting state first and then this TPU was employed as a modifier to enhance and plasticize PVC in another melt blending step. In comparison with the ternary blending method, this step‐by‐step melt blending method was more efficient and convenient. The distribution of graphene sheets in the polymer matrix is uniform and no C − Cl bond weakened effect can be observed. Due to the similar polarity, TPU showed good compatibility with PVC and its plasticizing effect allowed a broader range of low temperature flexibility of the modified PVC matrix. Moreover, other properties of the resultant PVC matrix (PTG‐x) including mechanical properties, thermal stability and plasticizer migration resistance were all found to be improved. With innovative applications in mind, the development of new graphene‐based materials will certainly lead to many future advances in science and technology. © 2017 Society of Chemical Industry
Determinants of patient activation in a community sample of breast and prostate cancer survivors
Authors: O'Malley Denalee , Dewan Asa A. , Ohman‐Strickland Pamela A. , Gundersen Daniel A. , Miller Suzanne M. , Hudson Shawna V. 
Published: January 2017

AbstractBackgroundPatient activation—the knowledge, skills, and confidence to manage one's health—is associated with improved self‐management behaviors for several chronic conditions. This study assesses rates of patient activation in breast and prostate cancer survivors and explores the characteristics associated with patient activation.MethodsA cross‐sectional study of survivors with localized (Stage I or II) breast and prostate cancers who were post‐treatment (between 1‐10+ years) were recruited from 4 community hospital sites in New Jersey. Survey data on patient characteristics (demographic and psychosocial) and clinical factors were assessed to explore the relationships with patient activation using the Patient Activation Measure–13.ResultsAmong 325 survivors (112 prostate; 213 breast), overall patient activation was high (M = 3.25). Activation was significantly lower among prostate survivors when compared with breast cancer survivors (M = 3.25 [SD, 0.38] vs M = 3.34 [SD, 0.37], P<.05). For prostate survivors, race (P < .05), marital status (P < .001), employment status (P < .01), household income (P < .05), and fear of recurrence (P < .01) were significantly associated with patient activation. For both groups, ease of access to oncology team and primary care physicians (PCPs) (all P values < .001) and perceptions of time spent with oncologists' team and PCPs (all P values < .01) were positive predictors of activation.ConclusionsIn both breast and prostate survivors, access to providers (both PCPs and oncologists) and perception that adequate time spent with providers were associated with activation. Therefore, clinical interventions maybe a promising avenue to improve patient activation. Research is needed to develop and test tailored patient activation interventions to improve self‐management among cancer survivors.
Testing a novel account of the dissociation between self‐reported memory problems and memory performance in chemotherapy‐treated breast cancer survivors
Authors: Paquet Lise , Verma Shailendra , Collins Barbara , Chinneck Anne , Bedard Marc , Song Xinni 
Published: January 2017

AbstractBackgroundA puzzling observation pertaining to the impact of breast cancer on memory is the frequently reported dissociation between breast cancer survivors' self‐reported memory problems and memory performance. We evaluated the hypothesis that the dissociation is related to the fact that the objective memory measures previously used assessed retrospective memory (RM) and did not tap prospective memory (PM), a domain about which survivors are complaining.MethodsIn a case‐healthy‐control (N = 80) cross‐sectional study, the Memory for Intention Screening Test was used to assess PM and the Wechsler Logical Memory Test was used to evaluate RM. Self‐reported problems were assessed with the Prospective and Retrospective Memory Questionnaire. Measures of depression (Center for Epidemiologic Studies Depression Scale) and fatigue (Functional Assessment of Cancer Therapy: Fatigue) were also administered.ResultsBoth groups reported more PM than RM problems (P < .001). Survivors reported more fatigue and depression symptoms and more memory problems than controls (all P < .001). Importantly, the group difference in self‐reported problems was no longer observed after adjusting for depression and fatigue. Survivors performed worse than controls on both PM and RM tasks. In neither group, however, were associations between self‐reported RM and PM problems and RM and PM objective performance observed.ConclusionsBreast cancer survivors exhibit PM and RM deficits, which do not correlate with self‐reported memory problems. Although unrelated to performance, memory complaints should not be dismissed, as they are closely associated with depression and fatigue and reveal an important facet of the cancer experience.
Mass rearing and augmentative biological control evaluation of Rhynocoris fuscipes (Hemiptera: Reduviidae) against multiple pests of cotton
Authors: Tomson Majesh , Sahayaraj Kitherian , Kumar Vivek , Avery Pasco B , McKenzie Cindy L , Osborne Lance S 
Published: January 2017

AbstractBACKGROUNDRhynocoris fuscipes (Fab.) (Hemiptera: Reduviidae) is a generalist predator of cotton pests and is commonly found inhabiting cotton‐growing regions in southern India. With the goal of integrating this predator in standard management practices used against cotton pests on a commercial scale, (1) we developed a protocol for adult group rearing of this predator inside micro‐environmental cages (MECs), and (2) we evaluated the biocontrol potential of mass‐produced predators against cotton pests under potted and field conditions.RESULTSHigher fecundity and adult longevity of R. fuscipes was recorded in the MECs than under natural growing conditions. The reduviid predator preferred stones and fallen leaves as hiding places in the MECs. The predator showed a higher biocontrol potential during the night hours against two pests, Phenacoccus solenopsis Tinsley and Dysdercus cingulatus (Fab.), than during the day under potted conditions. Under field conditions, R. fuscipes significantly reduced the population of Aphis gossypii Glover, P. solenopsis, D. cingulatus and Helicoverpa armigera (Hübner) by 28, 70, 29 and 50%, respectively. No negative impact of R. fuscipes was reported on other natural enemies present in the cotton agroecosystem.CONCLUSIONSignificantly higher crop yield and cost benefit ratio were observed in R. fuscipes‐released plots than in the control plots. The results suggest that R. fuscipes can be mass produced efficiently under controlled conditions in MECs, and used in an integrated management program for multiple cotton pests. © 2017 Society of Chemical Industry
Mechanisms of HIV persistence in HIV reservoirs
Authors: Mzingwane Mayibongwe L. , Tiemessen Caroline T. 
Published: January 2017

SummaryThe establishment and maintenance of HIV reservoirs that lead to persistent viremia in patients on antiretroviral drugs remains the greatest challenge of the highly active antiretroviral therapy era. Cellular reservoirs include resting memory CD4+ T lymphocytes, implicated as the major HIV reservoir, having a half‐life of approximately 44 months while this is less than 6 hours for HIV in plasma. In some individuals, persistent viremia consists of invariant HIV clones not detected in circulating resting CD4+ T lymphocytes suggesting other possible sources of residual viremia. Some anatomical reservoirs that may harbor such cells include the brain and the central nervous system, the gastrointestinal tract and the gut‐associated lymphoid tissue and other lymphoid organs, and the genital tract. The presence of immune cells and other HIV susceptible cells, occurring in differing compositions in anatomical reservoirs, coupled with variable and poor drug penetration that results in suboptimal drug concentrations in some sites, are all likely factors that fuel the continued low‐level replication and persistent viremia during treatment. Latently, HIV‐infected CD4+ T cells harboring replication‐competent virus, HIV cell‐to‐cell spread, and HIV‐infected T cell homeostatic proliferation due to chronic immune activation represent further drivers of this persistent HIV viremia during highly active antiretroviral therapy.
Detection of Hg2+ and Cs+ with a Rhodamine–based Sensor and Ethoxy–substituted Dihydroimidazole Ring Formation Associated with the Reduction of Hg2+ to Hg
Authors: Kumar Ashish , Sain Dibyendu , Kumari Chanda , Dey Swapan 
Published: January 2017

AbstractRhodamine based CS2 linked chemosensor (R1) was synthesized under green condition and it was applied instantly for the detection of Hg2+ ion. While R1 was refluxed with Hg2+ in ethanol, metal ion induced substitution reaction of ethoxy moiety onto imidazole ring via SN2 mechanism was observed upon chemical transformation. The hydroxide ion, transferred to the xanthene ring followed by reduction of Hg2+ to Hg was found. Despite of Hg2+, R1 also exhibited very sharp sensing ability for Cs+ at its very low concentration among all other metal ions. Sensing phenomena was established through UV‐Vis, fluorescence, NMR and mass spectroscopic techniques. Quantum chemical (DFT) calculation was supportive to establish all the complexation.
Synthesis of Highly Z‐Selective Coumarin Annulated Dioxocine, Dioxacindione and Macrocycles Using Grubbs’ Second‐Generation Catalyst
Authors: Goud E. Yadaiah , Rao B. Kanakadurga , Thirupahi G. , Hemasri Y. , Rao Ch. Prasad , Kumar P. Vijay , Rao Y. Jayaprakash 
Published: January 2017

AbstractThe diversity‐oriented organic synthesis of novel coumarin annulated tricyclic dioxocine, dioxacindione scaffolds with Z‐selectivity and the symmetrical pentacyclic coumarin macrocyclic derivatives is demonstrated from substituted hydroxyl coumarins via ring‐closing metathesis in the presence of Grubbs’ second‐generation catalyst as the facile and efficient route with excellent yields. This synthetic strategy provides a route for the intramolecular ring‐closing metathesis to access a library of novel tricyclic coumarin heterocycles and pentacyclic coumarin macrocycles having different ring systems.
Synthesis of a Water‐Soluble Pyrazole Curcumin Derivative: In Vitro and In Vivo AGE Inhibitory Activity and Its Mechanism
Authors: Sribalan Rajendran , Shakambari Ganeshan , Banuppriya Govindharasu , Varalakshmi Perumal , Subramanian Elayia Raja , Sudhakar Sivasubramanium , Padmini Vediappen 
Published: January 2017

AbstractThe new chemical entity, water‐soluble pyrazole curcumin derivative (PyCurOAc) was designed, synthesized and characterized for the purpose of inhibition of AGE formation. The compound showed an excellent in vitro AGEs inhibition activity than curcumin itself as well as the standard. Further, the AGE inhibition activity was substantiated in vivo using C.elegans as an animal model. The mechanistic investigation for the inhibition of AGEs with PyCurOAc was studied with glod‐4 expressions in C.elegans and glucose trapping method. This study suggests that the synthesized compound could be used to treat the formation of AGEs in hyperglycemic nematodes and higher animals.
A Green and Efficient One‐Pot Pseudo‐Five‐Component Reaction for Synthesis of Bis(pyrazol‐5‐ol) Derivatives via Tandem Cyclocondensation‐Knoevenagel–Michael Reaction
Authors: Yang Cheng , Liu Peng‐Ze , Xu Da‐Zhen 
Published: January 2017

AbstractA simple, green and efficient approach for one‐pot pseudo‐five‐component synthesis of the 4,4’‐(arylmethylene)bis(1H‐pyrazol‐5‐ol) derivatives from hydrazines, dialkyl acetylenedicarboxylats/β‐ketoesters and aromatic aldehydes catalyzed by Dabco‐base ionic liquids in aqueous media has been successfully developed. All the reactions were performed under 3 mol% of ionic liquid catalyst, and afforded the corresponding bis(pyrazol‐5‐ol)s in excellent yields (81‐98 %). This method also offers several other notable advantages, such as environmental friendliness, short reaction times, easy workup and reusability of the inexpensive catalyst.
5‐Hydroxymethylfurfural Production from Glucose, Fructose, Cellulose, or Cellulose–based Waste Material by Using a Calcium Phosphate Catalyst and Water as a Green Solvent
Authors: Mimura Naoki , Sato Osamu , Shirai Masayuki , Yamaguchi Aritomo 
Published: January 2017

AbstractWe successfully prepared 5‐hydroxymethylfurfural from glucose, fructose, cellulose, natural wood, waste paper, and cotton clothing by using a calcium phosphate catalyst and water as a green solvent. The combination of basic and acidic sites on the surface of the calcium phosphate catalyst accelerated the multistep reaction pathway from the reactants to 5‐hydroxymethylfurfural. Ball‐milling pretreatment of the reactant markedly increased the yield of 5‐hydroxymethylfurfural obtained from cellulose, natural wood, waste paper, and cotton clothing.
Psychosocial safety climate, emotional exhaustion, and work injuries in healthcare workplaces
Authors: Zadow Amy Jane , Dollard Maureen Frances , Mclinton Sarven Savia , Lawrence Peter , Tuckey Michelle Rae 
Published: January 2017

AbstractPreventing work injuries requires a clear understanding of how they occur, how they are recorded, and the accuracy of injury surveillance. Our innovation was to examine how psychosocial safety climate (PSC) influences the development of reported and unreported physical and psychological workplace injuries beyond (physical) safety climate, via the erosion of psychological health (emotional exhaustion). Self‐report data (T2, 2013) from 214 hospital employees (18 teams) were linked at the team level to the hospital workplace injury register (T1, 2012; T2, 2013; and T3, 2014). Concordance between survey‐reported and registered injury rates was low (36%), indicating that many injuries go unreported. Safety climate was the strongest predictor of T2 registered injury rates (controlling for T1); PSC and emotional exhaustion also played a role. Emotional exhaustion was the strongest predictor of survey‐reported total injuries and underreporting. Multilevel analysis showed that low PSC, emanating from senior managers and transmitted through teams, was the origin of psychological health erosion (i.e., low emotional exhaustion), which culminated in greater self‐reported work injuries and injury underreporting (both physical and psychological). These results underscore the need to consider, in theory and practice, a dual physical–psychosocial safety explanation of injury events and a psychosocial explanation of injury underreporting.
Secondary traumatic stress and secondary posttraumatic growth in a sample of Dutch police family liaison officers
Authors: Kunst M.J.J. , Saan M.C. , Bollen L.J.A. , Kuijpers K.F. 
Published: January 2017

AbstractThis study investigated secondary traumatic stress (STS) and secondary posttraumatic growth (SPG) in a sample of Dutch police family liaison officers (N = 224). Our study had two aims: (a) to identify potential risk and protective factors for STS and (b) to investigate the association between STS and SPG. None of the risk (caseload and a personal trauma history) and protective factors (age, work experience, and support by supervisors and coworkers) identified in previous research correlated with STS. However, a small positive association was found between STS and SPG. In the discussion section we warn against the use of interventions that aim to prevent STS until more is known about risk and protective factors for STS and provide directions for future research.
Windfalls of emperors' sojourns: Stock market reactions to Chinese firms hosting high‐ranking government officials
Authors: Schuler Douglas A. , Shi Wei , Hoskisson Robert E. , Chen Tao 
Published: January 2017

Research summary: We contribute to the corporate political activity (CPA) literature by showing that investors value companies that host visits of high‐ranking government officials (President and Premier). We argue that investors may value host official visits for two reasons: (1) the signal received about possibility of firm accessing government‐controlled resources via promotion or protection; and (2) the certification effect from such high‐powered visitors elevating the firm's reputation and legitimacy. Results from an event study analysis of 84 high‐ranking government official visits in China from 2003 to 2011 indicate that investors responded positively to host firms as reflected by stock market performance. Furthermore, the greatest positive reactions accrued to firms experiencing weaker prior period financial performance and to firms that are privately compared to state‐controlled.Managerial summary: Do visits by high‐ranking government officials influence firm stock market performance? Studying a sample of Chinese public firms that hosted 84 visits by the Chinese President and the Premier from 2003 to 2011, we find that investors reacted positively to such visits compared with a group of non‐host firms from the same industry and with similar financial performance and size. In addition, firms with weaker prior financial performance and private firms benefit the most from hosting such visits. Our findings imply that hosting visits of high‐ranking government officials can signal future government‐controlled resource inflows and boost host firms' reputation and legitimacy. Copyright © 2016 John Wiley & Sons, Ltd.
Sampled suffix array with minimizers
Authors: Grabowski Szymon , Raniszewski Marcin 
Published: January 2017

SummarySampling (evenly) the suffixes from the suffix array is an old idea trading the pattern search time for reduced index space. A few years ago Claude et al. showed an alphabet sampling scheme allowing for more efficient pattern searches compared with the sparse suffix array, for long enough patterns. A drawback of their approach is the requirement that sought patterns need to contain at least one character from the chosen subalphabet. In this work, we propose an alternative suffix sampling approach with only a minimum pattern length as a requirement, which is more convenient in practice. Experiments show that our algorithm (in a few variants) achieves competitive time‐space tradeoffs on most standard benchmark data. Copyright © 2017 John Wiley & Sons, Ltd.
The Epa Guidance on Suicide Treatment and Prevention Needs to Be Adjusted to Fight The Epidemics of Suicide at the North Pole Area and Other Autochthonous Communities
Authors: Charlier P. , Malaurie J. , Wasserman D. , Carli V. , Sarchiapone M. , Dagenais-Everell C. , Herve C. 
Published: January 2017

AbstractMore and more, youth suicide in the Inuit community is gaining importance, with a frequency in Greenland rising from 14.4 (1960–64) to 110.4 per 100,000 person-years (2010–11). The huge cultural/educational changes during the last 20 years and the role of globalization, especially of the occidental influence on this community may be at the origin of such an “epidemics” of suicide in this cultural region. Recently, a political organization representing the Inuit community in Canada (ITK for Inuit Tapiriit Kanatami) launched a National Inuit Suicide Prevention Strategy (NISP) based on the specificities of this community in comparison to the occidental civilization. In fact, not only the Canadian Inuit community is concerned by this epidemics of suicide, but also many other autochthonous groups. In this context, the European Psychiatric Association (EPA) guidance on suicide treatment and prevention needs to be adjusted to autochthonous individuals’ needs.
Cellular protein and mRNA expression of β1 nicotinic acetylcholine receptor (nAChR) subunit in brain, skeletal muscle and placenta
Authors: Aishah Atqiya , Hinton Tina , Machaalani Rita 
Published: January 2017

AbstractThe β1 nicotinic acetylcholine receptor (nAChR) subunit is a muscle type subunit of this family and as such, is found predominantly in muscle. Recent reports document its expression in other tissues and cell lines including adrenal glands, carcinomas, lung and brain. However, the majority of studies were of tissue lysates, thus the cellular distribution was not determined. This study aimed to determine the cellular distribution of the β1 nAChR subunit in the brain, at both the mRNA and protein levels, using non‐radioactive in situ hybridization (ISH) and immunohistochemistry (IHC), respectively, and to compare it to two muscle tissue types, skeletal and placenta. Tissue was formalin fixed and paraffin embedded (all tissue types) and frozen (placenta) from humans. Additional control tissue from the piglet and mouse brain were also studied, as was mRNA for the α3 nAChR and N‐methyl‐d‐aspartate receptor 1 (NR1) subunit. We found no β1 nAChR subunit mRNA expression in the human and piglet brain despite strong protein expression. Some signal was seen in the mouse brain but considered inconclusive given the probes designed were not of 100% homology to the mouse. In the skeletal muscle and placenta tissues, β1 nAChR subunit mRNA expression was prominent and mirrored protein expression. No α3 nAChR or NR1 mRNA was seen in the skeletal muscle, as expected, although both subunit mRNAs were present in the placenta. This study concludes that further experiments are required to conclusively state that the β1 nAChR subunit is expressed in the human, piglet and mouse brain.