bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parathyroid hormone as a marker for hypoperfusion in trauma: A prospective observational study
Authors: Fligor Scott C. , Love Katie M. , Collier Bryan R. , Lollar Daniel I. , Hamill Mark E. , Benson Andrew D. , Bradburn Eric H. 
Published: July 2017

BACKGROUND
Hyperparathyroidism is common in critical illness. Intact parathyroid hormone has a half-life of 3 minutes to 5 minutes due to rapid clearance by the liver, kidneys, and bone. In hemorrhagic shock, decreased clearance may occur, thus making parathyroid hormone a potential early marker for hypoperfusion. We hypothesized that early hyperparathyroidism predicts mortality and transfusion in trauma patients.

METHODS
A prospective observational study was performed at a Level I trauma center in consecutive adult patients receiving the highest level of trauma team activation. Parathyroid hormone and lactic acid were added to the standard laboratory panel drawn in the trauma bay on arrival, before the administration of any blood products. The primary outcomes assessed were transfusion in 24 hours and mortality.

RESULTS
Forty-six patients were included. Median age was 47 years, 82.6% were men, 15.2% suffered penetrating trauma, and 21.7% died. Patients who were transfused in the first 24 hours (n = 17) had higher parathyroid hormone (182.0 pg/mL vs. 73.5 pg/mL, p < 0.001) and lactic acid (4.6 pg/mL vs. 2.3 pg/mL, p = 0.001). Patients who did not survive to discharge (n = 10) also had higher parathyroid hormone (180.3 pg/mL vs. 79.3 pg/mL, p < 0.001) and lactic acid (5.5 mmol/L vs. 2.5 mmol/L, p = 0.001). For predicting transfusion in the first 24 hours, parathyroid hormone has an area under the receiver operating characteristic curve of 0.876 compared with 0.793 for lactic acid and 0.734 for systolic blood pressure. Parathyroid hormone has an area under the receiver operating characteristic curve of 0.875 for predicting mortality compared with 0.835 for lactic acid and 0.732 for systolic blood pressure.

CONCLUSION
Hyperparathyroidism on hospital arrival in trauma patients predicts mortality and transfusion in the first 24 hours. Further research should investigate the value of parathyroid hormone as an endpoint for resuscitation.

LEVEL OF EVIDENCE
Prognostic, level II.
The maternal genetic history of the Angolan Namib Desert: a key region for understanding the peopling of southern Africa
Authors: Oliveira Sandra , Fehn Anne-Maria , Aço Teresa , Lages Fernanda , Gayá-Vidal Magdalena , Pakendorf Brigitte , Stoneking Mark , Rocha Jorge 
Published: July 2017

ABSTRACTSouthern Angola is a poorly studied region, inhabited by populations that have been associated with different migratory movements into southern Africa. Besides the long-standing presence of indigenous Kx’a-speaking foragers and the more recent arrival of Bantu-speaking pastoralists, ethnographic and linguistic studies have suggested that other pre-Bantu communities were also present in the Namib desert, including peripatetic groups like the Kwepe (formerly Kwadi speakers), Twa and Kwisi. Here we evaluate previous peopling hypotheses by analyzing the relationships between seven groups from the Namib desert (Kuvale, Himba, Tjimba, Kwisi, Twa, Kwepe) and Kunene Province (!Xun), based on newly collected linguistic data and 295 complete mtDNA genomes. We found that: i) all groups from the Namib desert have genealogically-consistent matriclanic systems that had a strong impact on their maternal genetic structure by enhancing genetic drift and population differentiation; ii) the dominant pastoral groups represented by the Kuvale and Himba were part of a Bantu proto-population that also included the ancestors of present-day Damara and Herero peoples from Namibia; iii) Tjimba are closely related to the Himba; iv) the Kwepe, Twa and Kwisi have a divergent Bantu-related mtDNA profile and probably stem from a single population that does not show clear signs of being a pre-Bantu indigenous group. Taken together, our results suggest that the maternal genetic structure of the different groups from the Namib desert is largely derived from endogamous Bantu peoples, and that their social stratification and different subsistence patterns are not indicative of remnant groups, but reflect Bantu-internal variation and ethnogenesis.
Synthetically EngineeredMedeaGene Drive System in the Worldwide Crop Pest,D. suzukii
Authors: Buchman Anna , Marshall John M. , Ostrovski Dennis , Yang Ting , Akbari Omar S. 
Published: July 2017

AbstractSynthetic gene drive systems possess enormous potential to replace, alter, or suppress wild populations of significant disease vectors and crop pests; however, their utility in diverse populations remains to be demonstrated. Here, we report the creation of the first-ever syntheticMedeagene drive element in a major worldwide crop pest,D. suzukii. We demonstrate that this drive element, based on an engineered maternal “toxin” coupled with a linked embryonic “antidote,” is capable of biasing Mendelian inheritance rates with up to 100% efficiency. However, we find that drive resistance, resulting from naturally occurring genetic variation and associated fitness costs, can hinder the spread of such an element. Despite this, our results suggest that this element could maintain itself at high frequencies in a wild population, and spread to fixation, if either its fitness costs or toxin resistance were reduced, providing a clear path forward for developing future such systems.
GPS2 regulates mitochondria biogenesis via mitochondrial retrograde signaling and chromatin remodeling of nuclear-encoded mitochondrial genes
Authors: Cardamone Maria Dafne , Tanasa Bogdan , Cederquist Carly , Huang Jiawen , Mahdaviani Kiana , Li Wembo , Rosenfeld Michael G. , Liesa Marc , Perissi Valentina 
Published: July 2017

SummaryAs most of the mitochondrial proteome is encoded in the nucleus, mitochondrial functions critically depend on nuclear gene expression and bidirectional mito-nuclear communication. However, mitochondria-to-nucleus communication pathways are incompletely understood. Here, we identify G-Protein Pathway Suppressor 2 (GPS2) as a mediator of mitochondrial retrograde signaling and a key transcriptional activator of nuclear-encoded mitochondrial genes in mammals. GPS2 regulated translocation from mitochondria to nucleus is essential for the transcriptional activation of the nuclear stress response to mitochondrial depolarization and for supporting basal mitochondrial biogenesis in differentiating adipocytes and in brown adipose tissue from mice. In the nucleus, GPS2 recruitment to target gene promoters regulates histone H3K9 demethylation and RNA Polymerase II (POL2) activation through inhibition of Ubc13-mediated ubiquitination. Together, these findings reveal an unexpected layer of regulation of mitochondrial gene transcription as they uncover a novel mitochondria-nuclear communication pathway.
Value appropriation in Brazilian cattle industry
Authors: de Oliveira Gustavo Magalhães , de Queiroz Caleman Silvia Morales , Cunha Christiano França da , Puperi Morenise 
Published: July 2017

PurposeThe purpose of this paper is to examine the influencing factors on cattle breeders’ payment system choices using cross-sectional data collected in the Brazilian states of Mato Grosso do Sul and Rio Grande do Sul. The investigation aims to analyze the problem of value appropriation comparing the payment based on carcass index with live weight mode under the perspective of “bovine for slaughtering” as a multidimensional product with various attributes.Design/methodology/approachThis study employs a generalized order logistic regression model in a survey with 69 cattle breeders’ interview to conduct the empirical analysis.FindingsThe empirical results show that measurement difficulties and collective actions influence farmers’ choice to a less efficient payment system in quality terms and value appropriation problems, while the trust level in the slaughterhouse pushes to a more efficient system. Furthermore, trust was presented as more important than technological aspects and long-time relationship as well as collective action corroborates to increase bargaining power and to solve conflicts. In sum, trust, measurement and bargaining power brought traditional and alternative solutions to solve conflicts such as well-designed payment indicators, collective actions and transaction costs.Originality/valueThis study used first-hand survey and proxy variables on cattle farmers’ payment system choices. Another contribution is the focus on two regions with two different payment systems in the same institutional environment in a way to suggest mechanisms of private strategies and public policy to reduce opportunistic value appropriation as well as decreasing conflict.
Organizational virtuousness perceptions and task crafting
Authors: Hur Won-Moo , Shin Yuhyung , Rhee Seung-Yoon , Kim Hyosun 
Published: July 2017

PurposeThe purpose of this paper is to examine the relationship between employees’ perceptions of organizational virtuousness and task crafting, and to test the mediating roles of organizational identification and work engagement in this relationship.Design/methodology/approachThe authors collected questionnaires from 175 Korean flight attendants and conducted structural equation modeling analyses.FindingsEmployees’ perceptions of organizational virtuousness were positively associated with task crafting. While organizational identification was not solely responsible for mediating this relationship, it intervened in the relationship between organizational virtuousness perceptions and task crafting by affecting work engagement.Research limitations/implicationsWhile this study provides important insights into the roles of organizational virtuousness, organizational identification, and work engagement in promoting task crafting, the use of self-reported, cross-sectional data limits causal inferences between variables.Practical implicationsBased on the present findings, managers can better understand the antecedents and mediating processes affecting employees’ task crafting.Originality/valueThis study adds value to the positive organizational psychology literature by revealing crucial intermediary processes linking organizational virtuousness perceptions and task crafting, thus suggesting reciprocity and social identity-based motivation as potential underlying mechanisms of task crafting.
Effects of different types of feedback of a mobile-assisted learning application and motivation towards mathematics learning on students’ mathematics performance
Authors: Bringula Rex , De Leon Jan Sepli , Rayala Kharl John , Pascual Bernadette Anne , Sendino Kevin 
Published: July 2017

Purpose
The purpose of this study is to determine the effects of four different forms of feedback (such as, complete solution, line-by-line correction, line-by-line hint and correct-incorrect final answer) of a mobile-assisted learning application on linear equations and motivation of students towards mathematics learning on students’ mathematics performance.

Design/methodology/approach
Totally, 285 Grade 7 students (72 students each for the first-three feedback and 69 students for the last feedback) participated in the five-day experiment. A validated instrument was utilized to determine the motivation of students in learning mathematics.

Findings
It was revealed that students solved more problems and spent more time in the line-by-line hint type of feedback. The correct-incorrect final answer group had the most number of incorrect problems solved. It was found that the scores of the students would be different from one another after they utilized the app. Nonetheless, all of them learnt significantly from the app. Five steps of hierarchical regression revealed that all types of feedback were consistent predictors of posttest scores. Thus, the first null hypothesis stating that there is no significant difference between the pretest and posttest scores of the students when categorized by different forms of feedback was rejected. The second null hypothesis stating that the four types of feedback and motivation of students do not influence mathematics performance is partially rejected.

Research limitations/implications
The study can be replicated in a school with a different atmosphere.

Practical implications
The use of the application is highly recommended for students who are beginning to learn linear equations. Teachers can replicate the four types of feedback in an actual classroom setting.

Originality/value
It was confirmed that the four types of feedback can teach the students learn mathematics, regardless of the motivation of the students.
Improving entity linking with ontology alignment for semantic microservices composition
Authors: Salvadori Ivan Luiz , Huf Alexis , Oliveira Bruno C.N. , dos Santos Mello Ronaldo , Siqueira Frank 
Published: July 2017

Purpose
This paper aims to propose a method based on Linked Data and Semantic Web principles for composing microservices through data integration. Two frameworks that provide support for the proposed composition method are also described in this paper: Linkedator, which is responsible for connecting entities managed by microservices, and Alignator, which aligns semantic concepts defined by heterogeneous ontologies.

Design/methodology/approach
The proposed method is based on entity linking principles and uses individual matching techniques considering a formal notion of identity. This method imposes two major constraints that must be taken into account by its implementation: architectural constraints and resource design constraints.

Findings
Experiments were performed in a real-world scenario, using public government data. The obtained results show the effectiveness of the proposed method and that, it leverages the independence of development and composability of microservices. Thereby, the data provided by microservices that adopt heterogeneous ontologies can now be linked together.

Research limitations/implications
This work only considers microservices designed as data providers. Microservices designed to execute functionalities in a given application domain are out of the scope of this work.

Originality/value
The proposed composition method exploits the potential data intersection observed in resource-oriented microservice descriptions, providing a navigable view of data provided by a set of interrelated microservices. Furthermore, this study explores the applicability of ontology alignments for composing microservices.
Psychological contract as precursor for turnover and self-employment
Authors: van Stormbroek Rosalie , Blomme Rob 
Published: July 2017

PurposeThe purpose of this paper is to examine the effect of psychological contract (PC) fulfilment and violation on turnover intention and self-employment intentions.Design/methodology/approachA sample of 132 Dutch organizationally employed individuals was used to test the effect of PC fulfilment on turnover intention and self-employment intention. Also, mediation effects of violation on the relation between PC fulfilment and turnover intention and its effect on the relation between PC fulfilment and self-employment intention were examined.FindingsConsistent with existing literature, the results show that lower ratings for PC fulfilment and feelings of violation of this contract can explain intentions to leave. Moreover, the results demonstrate that lower ratings for PC fulfilment are also related to self-employment intentions. This relationship is partly mediated by turnover intentions.Research limitations/implicationsThis research measured intention to turnover, thus not the actual turnover. In addition, self-employment was measured by means of a self-designed scale.Practical implicationsManaging the PC is a delicate but crucial process to prevent valuable employees from leaving the organization.Originality/valueThe paper contributes to the literature on PC fulfilment and employee attitude. In addition, little is known about the influence of PC fulfilment on an employee’s intention to pursue self-employment.
Preferences among real estate journals: perceptions vs reality
Authors: Boshoff Douw Gert Brand , Parker David 
Published: July 2017

PurposeThe purpose of this paper is to examine the real estate journal ranking by comparing journal performance statistics to researcher preferences.Design/methodology/approachThe study is based on a survey of members of the International Real Estate Society and sister societies with comparison to impact statistics for real estate journals which are analysed using data from Google Scholar.FindingsThe findings show a high correlation between researcher preferences and the empirical results, supporting the findings of previous research in this area. However, while most previous studies were conducted on high-impact US journals only, these are still found to be amongst the highest ranked overall even with inclusion of other international journals. There are, however, some differences found, such as the perception of researchers on electronic vs hard copy journals, which were found to be moving more towards the former.Practical implicationsThe results provide a ranking of various real estate journals, especially with regard to other international journals not included in the previous studies that are dominated by high-impact US journals, providing a guideline on where to publish. The paper also shows the methodology used in order to determine how the journals are ranked, which could be applied to other journals not included in this study in order for researchers to make informed decisions concerning publication choices.Originality/valueThis paper extends the research on this topic by analysing the preferences and statistics of a broader international sample of journals and compares researcher preferences to empirical analysis.
No carbon “bet hedging” in pine seedlings under prolonged summer drought and elevated CO2
Authors: Bachofen Christoph , Moser Barbara , Hoch Günter , Ghazoul Jaboury , Wohlgemuth Thomas 
Published: July 2017

Abstract

More frequent drought episodes are expected to cause higher mortality in isohydric tree species such as pines, because individuals close their stomata early during drought in order to maintain constant needle water potentials. It has been suggested that trees delay the ensuing carbon starvation by actively storing carbon at the expense of growth (“bet hedging”). Because such a strategy is only adaptive in drought‐prone regions, we hypothesise that the degree of carbon “bet hedging” should differ between ecotypes.

We repeatedly measured the allocation of biomass, starch and soluble sugars to needles, stem and roots in seedlings of nine populations of Pinus sylvestris and Pinus nigra along a gradient from Central Europe to the Mediterranean. During two consecutive growing seasons, seedlings grown from seed were exposed to factorial combinations of 4 months of drought (D1, D2) and ambient/elevated CO2 (aCO2/eCO2).

Drought‐stressed pine seedlings did neither increase starch concentrations, nor change biomass production or experience lower mortality under eCO2 compared to aCO2. By the end of D2, seedlings from drier origin had accumulated more starch but at the same time also more biomass than seedlings from wetter origin.

Surprisingly, seedlings acclimatised to dry conditions after D1 so that mortality dropped to zero and drought effects on needle starch (P. sylvestris) and overall starch (P. nigra), respectively, disappeared after D2.

Synthesis. The absence of a trade‐off between carbon storage (starch) and growth (biomass), and the patterns of mortality observed in seedlings growing under combined drought and eCO2 do not support the theory of carbon “bet hedging” in isohydric Pinus sylvestris and Pinus nigra. Results suggest that reduced growth and acclimatisation minimised seedling mortality in the second year. Acclimatisation might thus enable pine seedlings to resist a moderate increase in summer drought frequency expected in the future.
Y‐chromosome and mtDNA variation confirms independent domestications and directional hybridization in South American camelids
Authors: Marín J. C. , Romero K. , Rivera R. , Johnson W. E. , González B. A. 
Published: July 2017

SummaryInvestigations of genetic diversity and domestication in South American camelids (SAC) have relied on autosomal microsatellite and maternally‐inherited mitochondrial data. We present the first integrated analysis of domestic and wild SAC combining male and female sex‐specific markers (male specific Y‐chromosome and female‐specific mtDNA sequence variation) to assess: (i) hypotheses about the origin of domestic camelids, (ii) directionality of introgression among domestic and/or wild taxa as evidence of hybridization and (iii) currently recognized subspecies patterns. Three male‐specific Y‐chromosome markers and control region sequences of mitochondrial DNA are studied here. Although no sequence variation was found inSRYandZFY, there were seven variable sites inDBYgenerating five haplotypes on the Y‐chromosome. The haplotype network showed clear separation between haplogroups of guanaco–llama and vicuña–alpaca, indicating two genetically distinct patrilineages with near absence of shared haplotypes between guanacos and vicuñas. Although we document some examples of directional hybridization, the patterns strongly support the hypothesis that llama (Lama glama) is derived from guanaco (Lama guanicoe) and the alpaca (Vicugna pacos) from vicuña (Vicugna vicugna). Within male guanacos we identified a haplogroup formed by three haplotypes with different geographical distributions, the northernmost of which (Peru and northern Chile) was also observed in llamas, supporting the commonly held hypothesis that llamas were domesticated from the northernmost populations of guanacos (L. g. cacilensis). Southern guanacos shared the other two haplotypes. A second haplogroup, consisting of two haplotypes, was mostly present in vicuñas and alpacas. However, Y‐chromosome variation did not distinguish the two subspecies of vicuñas.
Factors associated with attrition rate in a supportive care service for substance using pregnant women in Brazil
Authors: Avilla Rosa Marina , Surjan Juliana , de Fátima Ratto Padin Maria , Canfield Martha , Laranjeira Ronaldo Ramos , Mitsuhiro SandroSendin 
Published: July 2017

Background and ObjectivesRetaining substance using women in antenatal care remains a major challenge. This study explored factors associated with attrition rate among women with substance use problems attending a supportive care service during pregnancy and soon after the birth of the infant.MethodsRecords of 166 women's antenatal consultations were analyzed.ResultsAttrition rate was high (75/166, 45.2%), and was associated with women having no schooling/primary schooling only, no family contact, having child(ren), crack‐cocaine use, poly drug use, and substance use problems by the expected child's father.Discussion and ConclusionsAttrition may be the outcome of socio‐demographic, family, individual, and substance use issues not fully addressed in prenatal interventions.Scientific SignificanceIdentification of who are at risk for dropping out affords services with an opportunity to prevent its occurrence. (Am J Addict 2017;26:676–679)