bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Easy Method for Intraoperative Confirmation of Lacrimal Sac Patency in Endoscopic Dacryocystorhinostomy
Authors: Pagella Fabio , Pusateri Alessandro , Matti Elina , Carena Paolo , Quiroa Luis , Antoniazzi Elena , Emanuelli Enzo 
Published: December 2016

Purpose Few studies have focused on the intranasal localization of the lacrimal sac during endoscopic dacryocystorhinostomy: landmarks in order to find the medial wall of the lacrimal sac have been described, but there is a lack of description of methods for the verification of the complete marsupialization of the lacrimal sac during surgery. In this report, we propose an easy and effective method for certain intraoperative identification of lacrimal sac. Methods A method in order to verify the effective marsupialization of the lacrimal sac is applied and described: to ensure that the opening of the sac in the nasal cavity is complete, the surgeon should identify the Rosenmuller valve, which is the end of the common canaliculus in the lacrimal sac. Continuous irrigation with saline solution through the inferior canaliculus can be useful to obtain a clean surgical area and to permit easy intraoperative identification of the valve. Results Between 2007 and 2015, 193 endoscopic dacryocystorhinostomies were performed in our institutions. Postoperative surgical success at last follow-up (minimum 12 months) was 93.8% (181 out of 193 of cases). No major complications were observed. Conclusions Correct and complete exposure of the lacrimal sac during surgery is crucial for a good outcome: when the opening of the common canaliculus is identified, the surgeon is assured that the sac has been correctly and completely marsupialized inside the nasal cavity.
Steady State Acetabular Cartilage Wear after Bipolar Hemiarthroplasty: A Case Series of 10 Patients with Radiostereometric Analysis
Authors: Tsukanaka Masako , Støen Ragnhild Ø. , Figved Wender , Frihagen Frede , Nordsletten Lars , Röhrl Stephan M. 
Published: December 2016

Introduction Cartilage wear is a concern after hemiarthroplasty. The precise pattern of the progression of wear has not been evaluated. We previously reported the application of radiostereonetric analysis (RSA) for the measurement of cartilage wear in patients. The purpose of this study was to report the amount and the orientation of the steady state wear of cartilage between 1 and 3 years after bipolar hemiarthroplasty. Methods 22 patients with a bipolar hemiarthroplasty for displaced femoral neck fracture were included. 10 patients completed the mean follow up of 37 months. The cartilage wear was evaluated by calculating the migration of the bipolar head in reference to the markers in the acetabulum using RSA. Results The mean age of the patients at the final follow-up was 80 (range 67-91) years. The 3-D migration was -0.02 mm (SD 0.30) between 1 and 3 years. The migration in each direction was 0.03 mm (SD 0.49) in medial, 0.03 mm (SD 0.14) in proximal and 0.11 mm (SD 0.29) in posterior directions. 2 patients showed migration of more than 0.2 mm. The large initial migration seen in some patients up to 1 year did not progress further. Total wear after 37 months was 0.43 mm (SD 0.17). Conclusions Cartilage wear progressed slowly in 2 of 10 patients from 1 to 3 years. No pelvic penetration was seen. We believe that RSA will give a basic knowledge about the development and the progression of cartilage wear after hemiarthroplasty.
Functional Outcomes of Infected Hip Arthroplasty: A Comparison of Different Surgical Treatment Options
Authors: Herman Benjamin V. , Nyland Mark , Somerville Lyndsay , MacDonald Steven J. , Lanting Brent A. , Howard James L. 
Published: December 2016

Background Periprosthetic joint infection (PJI) following total hip arthroplasty (THA) can be treated with irrigation and debridement with head and polyethylene exchange (IDHPE) or 2-stage revision (2SR). Few studies have compared patient-reported outcome measures (PROMs) in patients managed with these treatments. Methods A retrospective review identified 137 patients who had an infected primary THA between 1986-2013. Control cohorts were matched according to age and Charlton Comorbidity Index (CCI). Harris Hip Scores (HHS), Short Form 12 (SF12), and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores were compared between the control and infected cohorts. Results 68 patients underwent a 2SR and 69 patients underwent an IDHPE. IDHPE had a 59% success rate in eradicating infection. PROMs for the 2SR cohort were significantly worse than the noninfected controls (SF12-PCS [34.0 vs. 38.3, p = 0.03]; HHS [76.6 vs. 91.7, p<0.001]; and WOMAC [67.3 vs. 79.3, p = 0.005]). There were no significant differences between the noninfected cohort and the successful IDHPE. Significant differences were found between failed IDHPE and noninfected controls (SF12-PCS [42.5 vs. 34.0, p = 0.011]; HHS [92.3 vs. 79.6, p = 0.004]). There was only difference in SF12-MCS scores (50.3 vs. 57.3, p = 0.012) between the 2SR and failed IDHPE cohorts. Conclusions Patients treated with a successful IDHPE had similar outcomes to noninfected patients. Patients that failed IDHPE and went onto 2SR had similar outcomes to those that had a 2SR alone. IDHPE demonstrated a 59% success rate with PROMs equivalent to a noninfected cohort and should be considered in the treatment algorithm of infected THA.
Retrospective comparison of two different approaches for ultrasound-guided internal jugular vein cannulation in hemodialysis patients
Authors: Treglia Antonio , Musone Dario , Amoroso Francesco 
Published: December 2016

Background Prevalent hemodialysis patients with vascular access consisting of a central venous catheter (CVC) are continuously increasing over the years. Improvement in evolution and CVC placement procedures represents therefore an essential tool to enhance performance and reduce intraoperative and long-term CVC complications. Internal jugular vein (IJV) catheterization techniques are different according to ultrasound probe position in relation to vein axis and to needle direction in relation to ultrasound beam. Lateral in-plane (LIP) approach has been proposed to be advantageous compared to traditional anterior out-of-plane (AOP) technique. Methods In this retrospective nonrandomized study we evaluated outcomes of 337 hemodialysis CVCs positioned in our center (Dono Svizzero Hospital) between 2011 and 2016, 237 using the AOP technique and 100 using the LIP approach. Results We found no significant differences among considered outcomes (procedure success, arterial puncture, pneumothorax, first-use malfunction, kinking/pinching) between the two approaches. Conclusions In our experience AOP and LIP approaches have shown the same outcomes. However, we believe that the LIP technique has potential benefits and it should be considered in the decision process of IJV cannulation.
Vascular access types in patients starting hemodialysis after failed kidney transplant: does close nephrology follow-up matter?
Authors: Haq Naveed Ul , Abdelsalam Mohamed Said , Althaf Mohammed Mahdi , Khormi Abdulrahman Ali , Al Harbi Hassan , Alshamsan Bader , Albaqumi Mamdouh Nasser , Broering Dieter Clemens , Alkorbi Lutfi , Aleid Hassan Ali 
Published: December 2016

Background Native arteriovenous fistulae (AVFs) are preferred while central venous catheters (CVCs) are least suitable vascular access (VA) in patients requiring hemodialysis (HD). Unfortunately, around 80% of patients start HD with CVCs. Late referral to nephrologist is thought to be a factor responsible for this. We retrospectively analyzed the types of VA at HD initiation in renal transplant recipients followed by nephrologists with failed transplant. If early referral to nephrologist improves AVF use, these patients should have higher prevalence of AVF at HD initiation. Methods All patients who failed their kidney transplants from January 2002 to April 2013 were included in the study. Data regarding planning of VA by nephrologist, documented discussion about renal replacement therapy (RRT), estimated glomerular filtration rate (eGFR) at 6 months and last clinic visit before HD initiation, time of VA referral, and subsequent VA at dialysis initiation were gathered and analyzed. Results Eighty-three patients failed their transplants during study period. Data were inaccessible in six patients. Eleven patients started peritoneal dialysis (PD) while 66 started HD. Thirty-two had previous functioning VA while 34 needed VA. There were 11/34 patients (32%) with eGFR <15 mL/min at six months while 21/34 (61%) had eGFR <15 mL/min at last clinic visit before HD initiation. Only 11/34 (32%) had documented RRT discussion, 8/34 (24%) had VA referral, and 7/34 (21%) had vein mapping. A total of 30/34 (88.3%) started HD with CVC while 4/34 (11.3%) started HD with AVF (p<0.0001). Conclusions Early referral to nephrologist by itself may not improve VA care amongst patient with end-stage renal disease.
Gemcitabine-induced Thrombocytosis as a Potential Predictive Factor in Non-small Cell Lung Cancer: Analysis of 318 Patients
Authors: Canova Stefania , Cicchiello Federica , Agustoni Francesco , Bianchini Giampaolo , Abbate Maria Ida , Bidoli Paolo , Cortinovis Diego Luigi 
Published: December 2016

Introduction In spite of the progress in the treatment of non-small-cell lung cancer (NSCLC), the majority of patients with advanced disease still receive chemotherapy. Gemcitabine alone or combined with a platinum compound is a valid option. Thrombocytosis is a recognized prognostic factor in lung cancer and an adverse event that may occur during gemcitabine infusion. Methods We retrospectively evaluated all patients with NSCLC treated with first-line gemcitabine-based chemotherapy in two Italian hospitals. We assessed the onset of thrombocytosis within the third cycle of therapy and the relation between thrombocytosis and survival. Results We included 318 patients. Thrombocytosis occurred in 156 patients (49.1%). Median progression-free survival (PFS) was 5.6 months (95% CI, 4.7-6.9 months) in patients who developed thrombocytosis versus 6 months (95% CI, 5.1-7.2 months) in patients without thrombocytosis (p = 0.21). Median overall survival (OS) was 11.2 months (95% CI, 9.8-13.4 months) in patients with thrombocytosis versus 12 months (95% CI, 10.1-14.4 months) in patients without thrombocytosis (p = 0.25). We observed no difference in terms of PFS or OS according to age, sex, stage, chemotherapy (single-agent versus combination chemotherapy) and thrombocytosis. Conclusions Thrombocytosis is neither a prognostic nor a predictive factor for PFS or OS in patients with advanced NSCLC treated with first-line gemcitabine-based chemotherapy.
Phase II Multi-institutional Clinical Trial on a New Mixed Beam RT Scheme of IMRT on Pelvis Combined with a Carbon Ion Boost for High-risk Prostate Cancer Patients
Authors: Marvaso Giulia , Jereczek-Fossa Barbara A. , Vischioni Barbara , Ciardo Delia , Giandini Tommaso , Hasegawa Azusa , Cattani Federica , Carrara Mauro , Ciocca Mario , Bedini Nice , Villa Sergio , Morlino Sara , Russo Stefania , Zerini Dario , Colangione Sarah Pia , Panaino Costanza Maria Vittoria , Fodor Cristiana , Santoro Luigi , Pignoli Emanuele , Valvo Francesca , Valdagni Riccardo , De Cobelli Ottavio , Orecchia Roberto 
Published: December 2016

Purpose Definition of the optimal treatment schedule for high-risk prostate cancer is under debate. A combination of photon intensity modulated radiotherapy (IMRT) on pelvis with a carbon ion boost might be the optimal treatment scheme to escalate the dose on prostate and deliver curative dose with respect to normal tissue and quality of dose distributions. In fact, carbon ion beams offer the advantage to deliver hypofractionated radiotherapy (RT) using a significantly smaller number of fractions compared to conventional RT without increasing risks of late effects. Methods This study is a prospective phase II clinical trial exploring safety and feasibility of a mixed beam scheme of carbon ion prostate boost followed by photon IMRT on pelvis. The study is designed to enroll 65 patients with localized high-risk prostate cancer at 3 different oncologic hospitals: Istituto Europeo di Oncologia, Fondazione IRCCS Istituto Nazionale dei Tumori, and Centro Nazionale di Adroterapia Oncologica. The primary endpoint is the evaluation of safety and feasibility with acute toxicity scored up to 1 month after the end of RT. Secondary endpoints are treatment early (3 months after the end of RT) and long-term tolerability, quality of life, and efficacy. Results The study is not yet recruiting; in silico studies are ongoing and we expect to start recruitment by 2017. Conclusions The present clinical trial aims at improving the current treatment for high-risk prostate cancer, evaluating safety and feasibility of a new RT mixed-beam scheme including photons and carbon ions. Encouraging results are coming from carbon ion facilities worldwide on the treatment of different tumors including prostate cancers. Carbon ions combine physical properties allowing for high dose conformity and advantageous radiobiological characteristics. The proposed mixed beam treatment has the advantage to combine a photon high conformity standard of care IMRT phase with a hypofractionated carbon ion RT boost delivered in a short overall treatment time.
What is the Impact of Extracorporeal Shock Wave Lithotripsy on Semen Parameters? A Systematic Review and Meta-Analysis
Authors: Radfar Mohammad H. , Simforoosh Nasser , Sotoudeh Mehdi , Ramezani Mehdi H. , Mollakoochakian Mohammad J. , Nikravesh Maryam , Shemshaki Hamidreza 
Published: December 2016

Background Extracorporeal shock wave lithotripsy (ESWL) is an important tool for the management of urolithiasis. The effects of shockwaves on tissues are established. The aim of this meta-analysis is to evaluate the microscopic semen characteristics of young men before and after ESWL treatment for lower ureteral calculi. Methods Literature searches were performed following the Cochrane guidelines. We conducted a systematic review and meta-analysis that included six trials that investigated the effects of ESWL on semen parameters, including sperm concentration, motility, and hematospermia. Meta-analyses were performed using fixed and random-effects models with tests for publication bias and heterogeneity. Results Significant worsening was detected in sperm concentration and motility after ESWL between case and control groups (mean difference -17.23, 95% confidence interval -22.53 to -11.93, p<0.00001, mean difference -10.82, 95% confidence interval -18.56 to -3.07, p = 0.006). Rate of microscopic and macroscopic hematospermia was significantly higher after ESWL between case and control groups [risk ratio (RR) 40.00, 95% confidence interval 10.11-158.30, p<0.00001, RR 14.33, 95% confidence interval 2.82-72.90, p = 0.001]. All parameters recovered after 3 months. Conclusions This study showed sperm concentration, motility, and rate of hematospermia (microscopic and macroscopic) were affected by ESWL that was used for the treatment of lower ureteral stone. Long-term studies with a focus on male fertility (i.e., pregnancy rates) after ESWL are warranted.
Evaluation of Bone Metastases by 18F-Choline PET/CT in a Patient with Castration-Resistant Prostate Cancer Treated with Radium-223
Authors: Scalzi Piera , Baiocco Cinzia , Genovese Sabrina , Trevisan Antonella , Sirotova Zuzana , Poti Carlo 
Published: December 2016

Background To date, bone metastases remain the main cause of morbidity and mortality in patients with metastatic castration-resistant prostate cancer (mCRPC). Therefore, the combination of accurate early detection of bony disease and effective treatment of these lesions is crucial in the management of mCRPC patients, but clinical trials specifically designed to test novel approaches are currently lacking. Case Description This report describes the case of a 74-year-old male with bone mCRPC and symptomatic and biochemical progression, who underwent radium-223 therapy, following previous treatment failure. 18F-choline positron emission tomography (PET)/computed tomography (CT) was used to assess changes in skeletal tumor activity before and after radium-223. Changes in prostate-specific antigen and alkaline phosphatase were also determined. 18F-choline PET/CT showed that treatment with radium-223 was able to effectively reduce bone metastatic disease, and this was accompanied by an excellent metabolic response. Conclusions In clinical practice, metabolic assessment of lesions by 18F-choline PET/CT following radium-223 seems a valid approach to monitor treatment response. Until results from clinical trials become available, reporting of single cases relating to data on the use of this technique remains paramount.
Effect of fuel treatments and backfiring on the recovery of an obligate seeder-dominated heathland
Authors: Fernández Filgueira Cristina , Vega Hidalgo José A. 
Published: December 2016

Aim of study: To evaluate how a plant community responded to a backfire that occurred four years after application of different types of fuel-reduction treatments.Area of study: Erica umbellata Loefl. (L.)-dominated heathland in Galicia (NW Spain).Materials and Methods: Shrub cover surveys in 16 experimental plots from 2006 to 2014. Fuel reduction treatments (prescribed burning, clearing and mastication) were applied in the spring of 2006 and the area was burned by a wildfire in the summer of 2010.Main results: Shrub total cover recovered quickly after the backfire in both the treated and untreated areas, and the pre-treatment values were reached four years after the fire. Post-wildfire resprouting species cover recovery was not affected by fuel treatments. As a contrast, Erica umbellata cover reached levels similar to those in the untreated plots only in the areas treated by prescribed burning. After the wildfire, grasses cover recovery was greater in the treated than in the untreated areas and the effect lasted until the end of the study.Research highlights: Prescribed fire and backfire was favourable for Erica umbellata regeneration compared to clearing and mastication.Keywords: prescribed burning; clearing; mechanical shredding; Erica; wildfire.
Nanoceria and bulk cerium oxide effects on the germination of asplenium adiantum-nigrum spores
Authors: Gomez-Garay Aranzazu , Pintos Beatriz , Manzanera José Antonio , Prada Carmen , Martin Luisa , Gabriel y Galan José María 
Published: December 2016

Aim of study: The effect of cerium oxide engineered nanoparticles on the spore germination of the fern. Asplenium adiantum-nigrum.Area of study: France, Britanny Region, Finistére Department, Plougonvelin, in rocks near the sea.Material and methods: Asplenium spores were cultured in vitro on agar medium with Nano-CeO2 (less than 25 nm particle size) and bulk-CeO2. The addition of each nano- and bulk particles ranged from 0 to 3000 mg L-1. Observations on rhizoidal and prothallial cells during first stages of gametophyte development were made. The No-Observed-Adverse-Effect concentration (NOAEC) and Lowest-Observed-Adverse-Effect-Concentration (LOEC) values for spore germination rate data were analyzed. Main results: Germination was speeded up by 100 to 2000 mg L-1 nanoceria, while bulk cerium oxide had the same effect for 500 to 200 mg L-1 concentrations. Present results showed cellular damage in the protonema while rhizoid cells seemed not to be affected, as growth and membrane integrity remained.Research highlights: Both nanosized and bulk cerium oxide are toxic for the fern Asplenium adiantum-nigrum, although diverse toxicity patterns were shown for both materials. Diverse toxic effects have been observed: chloroplast membrane damage and lysis, cell wall and membrane disruption which leads to cell lysis; and alterations in morphology and development.Keywords: Nanoparticles; rhizoid; prothallus; chloroplast; fern.
Selection and evaluation of phosphate-solubilizing bacteria from grapevine rhizospheres for use as biofertilizers
Authors: Liu Min , Liu Xu , Cheng Bao-Sen , Ma Xue-Lei , Lyu Xiao-Tong , Zhao Xian-Fang , Ju Yan-Lun , Min Zhuo , Fang Yu-Lin 
Published: December 2016

Phosphate-solubilizing bacteria (PSB) have the ability to solubilize insoluble phosphorus (P) and release soluble P. Extensive research has been performed with respect to PSB isolation from the rhizospheres of various plants, but little is known about the prevalence of PSB in the grapevine rhizosphere. In this study, we aimed to isolate and identify PSB from the grapevine rhizosphere in five vineyards of Northwest China, to characterize their plant-growth-promoting (PGP) traits, evaluate the effect of stress on their phosphate-solubilizing activity (PSA), and test their ability to stimulate the growth of Vitis vinifera L. cv. Cabernet Sauvignon. From the vineyard soils, 66 PSB isolates were screened, and 10 strains with high PSA were identified by 16S rRNA sequencing. Sequence analysis revealed that these 10 strains belonged to 4 genera and 5 species: Bacillus aryabhattai, B. megaterium, Klebsiella variicola, Stenotrophomonas rhizophila, and Enterobacter aerogenes. The selected PSB strains JY17 (B. aryabhattai) and JY22 (B. aryabhattai) were positive for multiple PGP traits, including nitrogen fixation and production of indole acetic acid (IAA), siderophores, 1-aminocyclopropane-1-carboxylate (ACC) deaminase, chitinase, and protease. JY17 and JY22 showed strong PSA under stress conditions of high pH, high salt, and high temperature. Therefore, these two isolates can be used as biofertilizers in saline-alkaline soils. The inoculation with PSB significantly facilitated the growth of V. vinifera cv. Cabernet Sauvignon under greenhouse conditions. Use of these PSB as biofertilizers will increase the available P content in soils, minimize P-fertilizer application, reduce environmental pollution, and promote sustainable agriculture.
Wind Energy Potentials and Its Trend in the South China Sea
Authors: Osinowo Adekunle Ayodotun , Lin Xiaopei , Zhao Dongliang , Wang Zhifeng 
Published: December 2016

Using a 30year (1976-2005) daily high-resolution reanalysis wind field dataset assimilated from several meteorological data sources, the wind speed and power characteristics of the South China Sea (SCS) were investigated using the Weibull shape and scale parameters. The region in general showed good wind characteristics. This is shown by high annual mean wind speed and power density values which are 5.93 m/s and 273.84 W/m2 respectively. The calculated annual mean wind power resource attributes the region to a relatively high potential site for large- scale grid connected wind turbine applications. The wind power ranged between 96.27 W/m2 in May and 527.03 W/m2 in December. Furthermore, spatio-temporal variations showed that strong trends in wind power exist in Luzon strait in the northern SCS and Xisha, Zhongsha, Luzon, Liyue bank in the central SCS which are evaluated as high wind potential regions and may be rated as locations excellent for installation of large wind turbines for electrical energy generation. Non-significant and negative trends dominate the southern SCS and may therefore, be suitable for small wind applications. The wind power density exhibited a significant increasing trend of 1.4 W/m2 yr-1 in the SCS as a whole throughout the study period. The trend is strongest (2.8 W/m2 yr-1) in winter.