bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polysaccharides and Peptides With Wound Healing Activity From Bacteria and Fungi
Authors: Arslan Nazli Pinar , Orak Tugba , Ozdemir Aysenur , Altun Ramazan , Esim Nevzat , Eroglu Elvan , Karaagac Sinem Ilayda , Aktas Cigdem , Taskin Mesut 
Published: October 2024

ABSTRACTBacteria and fungi are natural sources of metabolites exhibiting diverse bioactive properties such as wound healing, antioxidative, antibacterial, antifungal, anti‐inflammatory, antidiabetic, and anticancer activities. Two important groups of bacteria or fungi‐derived metabolites with wound‐healing potential are polysaccharides and peptides. In addition to bacteria‐derived cellulose and hyaluronic acid and fungi‐derived chitin and chitosan, these organisms also produce different polysaccharides (e.g., exopolysaccharides) with wound‐healing potential. The most commonly used bacterial peptides in wound healing studies are bacteriocins and lipopeptides. Bacteria or fungi‐derived polysaccharides and peptides exhibit both the in vitro and the in vivo wound healing potency. In the in vivo models, including animals and humans, these metabolites positively affect wound healing by inhibiting pathogens, exhibiting antioxidant activity, modulating inflammatory response, moisturizing the wound environment, promoting the proliferation and migration of fibroblasts and keratinocytes, increasing collagen synthesis, re‐epithelialization, and angiogenesis. Therefore, peptides and polysaccharides derived from bacteria and fungi have medicinal importance. This study aims to overview current literature knowledge (especially within the past 5 years) on the in vitro and in vivo wound repair potentials of polysaccharides and peptides obtained from bacteria (Actinobacteria, Bacteroidetes, Cyanobacteria, Firmicutes, and Proteobacteria) and fungi (yeasts, filamentous microfungi, and mushrooms).
Metabolic insights into the mechanism of soybean reddening during storage
Authors: Xia Yunze , Zhang Huayang , Li Miao , Zhou Yuhao , Qu Chenling 
Published: October 2024

AbstractBACKGROUNDSoybean reddening during storage and transportation has caused great concern due to the serious economic loss. However, the mechanism of reddening has not been clearly elucidated. In this study, metabolomics was employed to investigate the reasons for soybean reddening during storage.RESULTSThe results of multivariate statistical analysis showed that the metabolite level of red soybean was significantly different from that of normal soybean. The differentially expressed metabolites were mainly enriched by biosynthesis of secondary metabolites and amino acid metabolism. Metabolism analysis showed that the biosynthesis of cyanidin and betalains was enhanced in reddening soybean. In addition, it was found that phenolic and flavonoid compounds decreased, while quinones, furans and 5‐hydroxymethylfurfural increased in reddening soybeans compared to normal soybeans.CONCLUSIONThe upregulation of cyanidin and betalains was the main reason for soybean reddening. Besides, the oxidation of phenols and flavonoids, as well as Maillard reaction, also contributed to the color change. © 2024 Society of Chemical Industry.
Recent Progress in Electro‐Optic Modulators: Physical Phenomenon, Structures Properties, and Integration Strategy
Authors: Yan Yixin , Zhang Haoran , Liu Xiaolei , Peng Liuxing , Zhang Qian , Yu Guangbin , Wu Qing , Li Haitao 
Published: October 2024

AbstractElectro‐optic modulators (EOMs), serving as indispensable components within photonic integrated circuits, are essential for enabling energy‐efficient, high‐speed, and high‐capacity optical communication systems. This review illustrates the principal physical phenomenon exploited in EOMs and provides a comprehensive analysis of the cutting‐edge EOMs featuring interference structures (Mach–Zehnder modulators and Michelson‐interferometer modulators) and resonance structures (microring modulators, racetrack modulators, and photonic crystal modulators). The comparative analysis of the performance merits and limitations in EOMs is presented, highlighting the combination of diverse electro‐optic material compositions with different optical structures, which reveals a promising integration strategic so as to pursue a trade‐off in modulation performance. It is contributed to the ongoing discourse on optimizing EOMs for the subsequent communication technologies and the advancement of photonic chips.
Learning health systems to implement chronic disease prevention programs: A novel framework and perspectives from an Australian health service
Authors: Wolfenden Luke , Wiggers John , Barnes Courtney , Lane Cassandra , Groombridge Daniel , Robertson Katie , Jones Jannah , McCrabb Sam , Hodder Rebecca K. , Shoesmith Adam , Hudson Nayerra , McCarthy Nicole , Kingsland Melanie , Doherty Emma , Princehorn Emily , Finch Meghan , Nathan Nicole , Sutherland Rachel 
Published: October 2024

AbstractBackgroundChronic diseases are a considerable burden to health systems, communities, and patients. Much of this burden, however, could be prevented if interventions effective in reducing chronic disease risks were routinely implemented.AimsThe aim of this paper is to discuss the role of public health agencies in preventing chronic disease through the application of learning health system (LHS) approaches to improve the implementation of evidence‐based interventions.Materials and MethodsWe draw on the literature and our experience operating a local LHS in Australia that has achieved rapid improvements in the implementation of chronic disease prevention interventions.ResultsThe proposed LHS framework has been adapted to be both implementation and chronic disease prevention focused. The framework describes both broad improvement processes, and the infrastructure and other support (pillars) recommended to support its core functions.ConclusionThe framework serves as a basis for further exploration of the potentially transformative role LHS's may have in addressing the chronic disease health crisis.
Metal‐Free, Light‐Catalyzed ATRP For the Synthesis of Functional PVDF‐Based Block Copolymers and Their Characterization
Authors: Altomare Aldo , Sognane Rouguy , Fiorito Alice , Loos Katja 
Published: October 2024

AbstractThe synthesis and characterization of poly(vinylidene fluoride) (PVDF)‐based block copolymers using a metal‐free light‐catalyzed atom transfer radical polymerization (ATRP) approach are described. A PVDF macroinitiator with C─Br bonds at both ends of the chain is synthesized, and an organic photoredox catalyst (OPRC) is used to control the process. The metal‐free process expands the possibilities for the synthesis and application of PVDF‐based block copolymers, as it allows the use of monomers that is previously incompatible with classical ATRP due to their interaction with metal catalysts. The synthesized block copolymers are characterized structurally and thermally as powder materials and in thin films. Fourier‐transform infrared spectroscopy (FT‐IR) analysis revealed that the crystalline phase of PVDF changes when thin films are formed. Specifically, the disappearance of the FT‐IR peaks related to the gamma phase and the presence of characteristic peaks related to the alpha and beta phases indicate that film formation rearranged the PVDF chains, leading to changes in their crystalline phases. These PVDF‐based block copolymers have unique properties, including high thermal stability, chemical resistance, and piezoelectricity, making them potential candidates for use in various fields, such as biomedical engineering, energy storage, and electronic devices.
Strong Kähler with torsion solvable lie algebras with codimension 2 nilradical
Authors: Brienza Beatrice , Fino Anna 
Published: October 2024

AbstractIn this paper, we study strong Kähler with torsion (SKT) and generalized Kähler structures on solvable Lie algebras with (not necessarily abelian) codimension 2 nilradical. We treat separately the case of ‐invariant nilradical and non‐‐invariant nilradical. A classification of such SKT Lie algebras in dimension 6 is provided. In particular, we give a general construction to extend SKT nilpotent Lie algebras to SKT solvable Lie algebras of higher dimension, and we construct new examples of SKT and generalized Kähler compact solvmanifolds.
Energy Metabolic Profile in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma: A Preliminary Landscape of Warburg Effect in Oral Cancer
Authors: Gonçalves Francisca Aurina , da Silva Bittencourt Leonardo , Barbosa Silvia , Diel Leonardo Francisco , Bernardi Lisiane , Matte Cristiane , Lamers Marcelo Lazzaron 
Published: October 2024

ABSTRACTWe hypothesized that cell energy metabolic profiles correlate with normal, dysplastic, and tumor cell/tissue statuses and may be indicators of aggressiveness in oral squamous cell carcinoma (OSCC) cells. The energy‐related proteins that were differentially expressed in human OSCC fragments (n = 3) and their adjacent epithelial tissue (TAE) were verified using mass spectrometry (MS). Immunohistochemistry for 4‐hydroxynonenal (4‐HNE) was performed to evaluate the oxidative stress patterns in OSCC (n = 10), epithelial dysplasia (n = 9), and normal epithelial (n = 4) biopsies. The metabolic energy profile of OSCC aggressiveness was investigated in human OSCC cell lines with different levels of epithelial–mesenchymal transition proteins. The genes associated with the proteins found by MS in this study were analyzed using survival analysis (OS), whereas the genes associated with a poorer prognosis were analyzed using context‐specific expression, Gene Ontology (GO) and Cancer Hallmarks for function enrichment analysis. The rationale for all experimental approach was to investigate whether the variation in energy metabolism profile accompanies the different phenotypes (from epithelial to mesenchymal) during the epithelial‐mesenchymal transition. All OSCC fragments exhibited an increase in glycolysis‐related proteins and a decrease in mitochondrial activity compared to the TAE region (p < 0.05), probably due to the downregulation of pyruvate dehydrogenase and antioxidant proteins. Additionally, the OSCC cell lines with a mesenchymal profile (SCC4, SCC9, and SCC25) had a lower mitochondrial mass and membrane potential and generated lower levels of reactive oxygen and nitrogen species than the TAE region. When we analyzed 4‐HNE, the reactive species levels were increased in the epithelial regions of OSCC and potentially malignant lesions. A decrease in the levels of 4‐HNE/reactive species was observed in the connective tissue underlying the dysplastic regions and the OSCC invasion zone. Based on this scenario, aggressive OSCC is associated with high glycolytic and oxidative metabolism and low mitochondrial and antioxidant activities, which vary according to the differentiation level of the tumor cells and the stage of carcinogenesis.
Vitamin B12 protects necrosis of acinar cells in pancreatic tissues with acute pancreatitis
Authors: Chen Yulin , Li Xue , Lu Ran , Lv Yinchun , Wu Yongzi , Ye Junman , Zhao Jin , Li Li , Huang Qiaorong , Meng Wentong , Long Feiwu , Huang Wei , Xia Qing , Yu Jianbo , Fan Chuanwen , Mo Xianming 
Published: October 2024

AbstractPharmacological agents regarding the most optimal treatments of acute pancreatitis remain. One‐carbon metabolism nutrients as therapeutic agents in many diseases might be involved in acute pancreatitis. The roles are acquired exploration in acute pancreatitis. We utilized Mendelian randomization to assess the causal impact of folate, homocysteine, and vitamin B12 (VB12) on acute pancreatitis. Wild‐type and corresponding genetically modified mouse models were used to verify the genetic correlating findings. A negative association between genetically predicted serum VB12 levels and risks of acute pancreatitis was identified in human population. The transcobalamin receptor (TCblR)/CD320 gene ablation that decreased cellular VB12 uptake and ATP production in pancreatic tissues promoted necrosis, resulting in much severe pathological changes of induced acute pancreatitis in mice. VB12 pretreatment and posttreatment dramatically increased ATP levels in pancreatic tissues and reduced the necrosis, then the elevated levels of amylase in serum, the levels of CK‐19, the activity of trypsin, and T lymphocyte infiltration in pancreatic tissues, prevented the pancreatic gross loss and ameliorated histopathological changes of mouse pancreases with induced acute pancreatitis. The results reveal that VB12 is potential as a therapeutic agent to inhibit tissue injuries and adaptive inflammatory responses in the pancreas in patients with acute pancreatitis.
The Influence of R&D Intensity on Supply Chain Transparency: Evidence From the Disclosure Substitution Perspective
Authors: Sun Junqin , Wang Fangjun , Lyu Chongchong , Wang Yu 
Published: October 2024

ABSTRACTThis paper shows that the existence of disclosure‐related costs and benefits explains the influence of R&D intensity on supply chain transparency. We find that R&D‐active firms are more likely to redact supply chain identities but disclose supply chain distribution as a substitution. The effect of withholding (disclosing) the specific identities (distribution) of supply chain is more (less) pronounced when firms are in higher competitive industries or non–state‐owned enterprises. Our study provides evidence of disclosure substitution behavior in a unified voluntary setting of supply chain transparency and shows that partial disclosure of nonproprietary information may be optimal.
Review of the 8th autumn school in chemoinformatics
Authors: Gasteiger Johann 
Published: October 2024

AbstractThis paper gives an overview of the lectures and posters presented at the 8th Autumn School in Chemoinformatics held in Nara, Japan on 28th ‐ 30th November 2023. The topics ranged from the study of chemical reactions through drug design and the use of Chemical Language Models and electronic structure informatics to the modeling of materials. In addition, a brief overview of the 50 years of work in chemoinformatics by Johann Gasteiger is given with an emphasis on the essential decisions during his scientific career.
Sperm Metabolism
Authors: Abruzzese Giselle Adriana , Sanchez‐Rodriguez Ana , Roldan Eduardo R. S. 
Published: October 2024

ABSTRACTBioenergetics plays a crucial role in sperm functions, including motility, capacitation‐related protein modifications, oocyte recognition and interaction, all of which are essential for fertilization. Sperm metabolism is recognized as flexible, responding to environmental cues and energetic demands during ejaculation, the journey along the female tract, and until fertilization. Recent studies suggest that sperm metabolic functions are relevant beyond fertilization and may influence zygote and embryo development, impacting paternal‐derived effects on offspring development and health. In recent years, sperm metabolic functions and homeostasis have gained increasing interest in male reproduction research. Given the crucial implications of sperm metabolism on fertility‐related processes, this field is of interest not only in human male fertility but also in livestock research, semen conservation, and assisted reproductive techniques. Newly developed assessment tools are allowing a better understanding of sperm metabolism under different conditions and identifying species‐specific peculiarities. This review aims to discuss the current knowledge of mammalian sperm metabolism, focusing on species‐specific features, changes during the sperm journey, and potential contributions to translational research and reproductive biotechnologies. Furthermore, we propose future perspectives on sperm bioenergetics research.
Consequences of Workplace Bullying From Nurses' Perspectives: A Qualitative Descriptive Study in Iran
Authors: Piri Saeedeh , Jalali Rostam , Khatony Alireza 
Published: October 2024

ABSTRACTAimThe aim of this study is to explore Iranian nurses' experiences regarding the consequences of bullying.DesignA qualitative descriptive study is carried out using conventional content analysis and Granheim and Lundman's method.MethodsData for this study were collected through 12 in‐depth, semi‐structured individual interviews with nurses employed at a teaching hospital in REDACTED, western Iran. Purposeful sampling was employed until data saturation was achieved. Data management was conducted using MAXQDA software.ResultsThe participants consisted of 12 nurses, with a mean age of 36.1 ± 8.6 years. Their experiences of workplace bullying were analysed and categorised into a main theme called ‘Consequences of Workplace Bullying’, with two categories identified as ‘Organisational Consequences’ and ‘Individual Consequences’. The organisational consequences were further elaborated through two subcategories: ‘work performance consequences’ and ‘patient care consequences’. The individual consequences category included subcategories including ‘psychosomatic consequences’, ‘psychological consequences’ and ‘family consequences’.ConclusionWorkplace bullying among nurses can have negative impacts on patients, nurses and organisations. In order to mitigate these effects, nurse managers can take proactive measures by implementing management strategies and fostering a positive work culture. By addressing the underlying factors and promoting a supportive environment, the adverse consequences of workplace bullying can be reduced or prevented.Patient or Public ContributionYes.
Analysis of Opioid Prescribing Trends Following Thyroidectomy and Parathyroidectomy Before and After the 2021 American Academy of Otolaryngology–Head and Neck Surgery Opioid Prescribing Clinical Practice Guidelines
Authors: Africa Robert E. , McKinnon Brian J. , Coblens Orly M. , Ranasinghe Viran J. , Shabani Sepehr 
Published: October 2024

AbstractObjectiveTo evaluate the trends in opioid and nonopioid prescribing for thyroidectomy and parathyroidectomy before and after the publication of guidelines by the American Academy of Otolaryngology–Head and Neck Surgery in April 2021.Study DesignRetrospective.SettingEighty‐three health care organizations in the United States that contribute to the TriNetX database.MethodsDeidentified patient data were retrieved from the TriNetX. Patients who were prescribed either opioids or nonopioid analgesic within 1 to 5 days following thyroid surgery and parathyroidectomy were included. Evaluation of the prescription trends was performed by interrupted time series analysis in Statistical Analysis System 9.4 with significance set at P < .05 to assess trends before and after the new opioid prescription guidelines.ResultsFor thyroid surgery, there was an immediate effect of the guideline change indicated by a 3.3% decrease in the opioid prescription trend (P = .03) and a significant increase in nonopioid use of overtime by 0.13% every 3 months (P < .0001). The opioid prescription trend following parathyroidectomy significantly decreased over time by 0.28% every 3 months (P < .0001), while the nonopioid prescription trend increased by 0.14% (P < .0001).ConclusionThere was an associated immediate reduction in the opioid prescribing trend for thyroidectomy, but the change was not sustained overtime. There was an associated decrease in the opioid prescribing trend for parathyroidectomy, but not immediately after the initial publication of the prescription guidelines.Level of EvidenceLevel III.
Augmented barrier properties of poly (lactic acid) composite packaging film reinforced by antibacterial hybrid bio‐filler: Extending the shelf life of fruits
Authors: Pradhan Sreemayee , N R Aswathy , G S Sudha , Samal Alaka , Mohapatra Aswini Kumar , Praharaj Payoja , Pandey Sony 
Published: October 2024

AbstractThis work investigates the construction of biodegradable packaging film based on polylactic acid (PLA) reinforced with a novel antibacterial hybrid nanofiller to improve barrier and mechanical properties. The study focuses on incorporating silver‐ingrained silica particles (Ag–In–Si) into PLA matrix to prepare the packaging film (Ag–In–SiPLA) that has superior antibacterial, and barrier property with negligible oxygen and water vapour penetration. The Ag was synthesized using natural neem leaf extract as a reducing agent. To ingrain silver over rice husk silica (Si) an in situ technique was adopted. Hence called Ag‐In‐Si bio‐filler. The Ag–In–SiPLA films were fabricated using melt blending and sheet extrusion methods by means of a micro‐compounder. The addition of rice husk silica served the purpose of cost‐effectiveness of the packaging film along with the enhancement of the oxygen and water barrier properties of the films. The optimized sample (PLA loaded with 3% Ag–In–Si), exhibited optimum transparency, moisture resistance, and barrier properties compared with control PLA film. The experiments on Muntingia calabura (Jamaica cherry) preservation have verified the remarkable effectiveness of Ag–In–SiPLA films in preserving their quality for an extended period. These biodegradable packaging films, composed of food‐grade materials and sustainable ingredients, have the potential to provide a compostable and environmentally friendly solution for various packaging applications. This research shed light on the antibacterial Ag–In–SiPLA film as a long‐term, high‐performance fruit packaging solution.Highlights
Novel antibacterial PLA composite with enhanced barrier and mechanical properties.
Silver‐ingrained silica particles improve antibacterial and barrier properties.
Green synthesis of silver using neem leaf extract
Melt blending and sheet extrusion used to create cost‐effective packaging films.
Ag–In–SiPLA films extend Muntingia calabura preservation, proving effective.
Suspended Droplets Discharge Characteristics
Authors: Chen Yanheng , Peng Binqi , Qiu Fangcheng , Zheng Xin , Li Hanyu , Peng Changzhi , Pei Xuekai 
Published: October 2024

ABSTRACTThis study investigates discharge phenomena in suspended droplets using needle–needle electrodes. By employing ultrasonic suspension technology for noncontact droplet suspension and high‐speed cameras for capturing time‐resolved discharge images, the study examines the impact of droplets on discharge characteristics and morphology. Results show that droplets alter the electric field distribution, affecting discharge paths. Low‐conductivity droplets hinder discharge, causing deflection or changes in the discharge channel, whereas high‐conductivity droplets act as suspended electrodes, facilitating discharge channel formation, reducing breakdown voltage and shortening the establishment time. Droplets transition from ellipsoid to flat and back during discharge, with high‐conductivity droplets potentially undergoing liquid explosion. These findings are crucial for designing high‐voltage equipment in liquid‐contaminated environments.
Pediatric pulmonology 2023 year in review: Asthma
Authors: Espaillat Andre , Loughlin Ceila E. , Stephenson Nicole 
Published: October 2024

AbstractCaring for children with asthma continues to be an essential responsibility of the pediatric pulmonologist. In this Pediatric Pulmonology Year in Review, we summarize the significant publications focused on pediatric asthma that have been published over the last year. Articles were selected from Pediatric Pulmonology and other relevant medical journals that historically publish in the field of pediatrics, and more specifically, pediatric asthma. Our aim was to highlight publications that may impact or change clinical practice. Once articles were collected, specific themes were chosen to best orient the reader to particular interests. In this review, we will discuss new findings that assist in the diagnosis and evaluation of pediatric asthma, highlight risk factors and social determinants that impact successful care, and discuss new interventions and treatment modalities for acute exacerbations and maintenance control. We hope this review can provide new insights and guidance for implementation into clinical practice within the field of pediatric asthma.