bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L
Authors: Tan Chunbin , Liu Zhaoming , Chen Senhua , Huang Xishan , Cui Hui , Long Yuhua , Lu Yongjun , She Zhigang 
Published: November 2016

AbstractThree novel 2,3-diaryl indone derivatives, ascomindones A−C (1−3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6−9) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the interpretation of spectroscopic data. 1 and 4 were further constructed by analysis of X-ray diffraction. Antioxidant properties based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavenging activities and the ferric reducing ability power (FRAP) of the new compounds were assayed. All of them exhibited significant effects, of which 1 showed more potent activity than ascorbic acid in scavenging DPPH radical with IC50 value of 18.1 μM.
Validation of the relative insensitivity of volumetric-modulated arc therapy (VMAT) plan quality to gantry space resolution
Authors: Murtaza Ghulam , Cora Stefania , Khan Ehsan Ullah 
Published: November 2016

Abstract
Volumetric-modulated arc therapy (VMAT) is an efficient form of radiotherapy used to deliver intensity-modulated radiotherapy beams. The aim of this study was to investigate the relative insensitivity of VMAT plan quality to gantry angle spacing (GS). Most previous VMAT planning and dosimetric work for GS resolution has been conducted for single arc VMAT. In this work, a quantitative comparison of dose–volume indices (DIs) was made for partial-, single- and double-arc VMAT plans optimized at 2°, 3° and 4° GS, representing a large variation in deliverable multileaf collimator segments. VMAT plans of six prostate cancer and six head-and-neck cancer patients were simulated for an Elekta SynergyS® Linac (Elekta Ltd, Crawley, UK), using the SmartArc™ module of Pinnacle³ TPS, (version 9.2, Philips Healthcare). All optimization techniques generated clinically acceptable VMAT plans, except for the single-arc for the head-and-neck cancer patients. Plan quality was assessed by comparing the DIs for the planning target volume, organs at risk and normal tissue. A GS of 2°, with finest resolution and consequently highest intensity modulation, was considered to be the reference, and this was compared with GS 3° and 4°. The differences between the majority of reference DIs and compared DIs were &lt;2%. The metrics, such as treatment plan optimization time and pretreatment (phantom) dosimetric calculation time, supported the use of a GS of 4°. The ArcCHECK™ phantom–measured dosimetric agreement verifications resulted in a &gt;95.0% passing rate, using the criteria for γ (3%, 3 mm). In conclusion, a GS of 4° is an optimal choice for minimal usage of planning resources without compromise of plan quality.
Identifying brain nociceptive information transmission in patients with chronic somatic pain
Authors: Davis Don A. , Ghantous Mariam E. , Farmer Melissa A. , Baria Alexis T. , Apkarian A. Vania 
Published: November 2016

Abstract

Introduction:
Recent advances regarding mechanisms of chronic pain emphasize the role of corticolimbic circuitry in predicting risk for chronic pain, independently from the site of injury-related parameters. These results compel revisiting the role of peripheral nociceptive signaling in chronic pain. We address this issue by examining what information brain circuitry transmits regarding the intensity of chronic pain and how this information may be related to a common comorbidity, depression.

Objectives:
To identify what information brain circuitry transmits regarding intensity of chronic somatic pain.

Methods:
Resting-state functional magnetic resonance imaging was used in a large group of patients with chronic pain (n = 40 chronic back pain and n = 44 osteoarthritis patients), and in comparison with healthy subjects (n = 88). We used a graph theoretical measure, degree count, to investigate voxelwise information sharing/transmission in the brain. Degree count, a functional connectivity–based measure, identifies the number of voxels functionally connected to every given voxel. Subdividing the chronic pain cohort into discovery, replication, and also for the overall group, we show that only degree counts of diencephalic voxels centered in the ventral–lateral thalamus reflected intensity of chronic pain, independently of depression.

Results:
Pain intensity was reliably associated with degree count of the thalamus, which was correlated negatively with components of the default mode network and positively with the periaqueductal gray (in contrast to healthy controls). Depression scores were not reliably associated with regional degree count.

Conclusion:
Collectively, the results suggest that, across 2 types of chronic pain, nociceptive-specific information is relayed through the spinothalamic pathway to the lateral thalamus, potentiated by pronociceptive descending modulation, and interrupting cortical cognitive processes.
RNA-protein binding motifs mining with a new hybrid deep learning based cross-domain knowledge integration approach
Authors: Pan Xiaoyong , Shen Hong-Bin 
Published: November 2016

AbstractBackgroundRNAs play key roles in cells through the interactions with proteins known as the RNA-binding proteins (RBP) and their binding motifs enable crucial understanding of the post-transcriptional regulation of RNAs. How the RBPs correctly recognize the target RNAs and why they bind specific positions is still far from clear. Machine learning-based algorithms are widely acknowledged to be capable of speeding up this process. Although many automatic tools have been developed to predict the RNA-protein binding sites from the rapidly growing multi-resource data, e.g. sequence, structure, their domain specific features and formats have posed significant computational challenges. One of current difficulties is that the cross-source shared common knowledge is at a higher abstraction level beyond the observed data, resulting in a low efficiency of direct integration of observed data across domains. The other difficulty is how to interpret the prediction results. Existing approaches tend to terminate after outputting the potential discrete binding sites on the sequences, but how to assemble them into the meaningful binding motifs is a topic worth of further investigation.ResultsIn viewing of these challenges, we propose a deep learning-based framework (iDeep) by using a novel hybrid convolutional neural network and deep belief network to predict the RBP interaction sites and motifs on RNAs. This new protocol is featured by transforming the original observed data into a high-level abstraction feature space using multiple layers of learning blocks, where the shared representations across different domains are integrated. To validate our iDeep method, we performed experiments on 31 large-scale CLIP-seq datasets, and our results show that by integrating multiple sources of data, the average AUC can be improved by 8% compared to the best single-source-based predictor; and through cross-domain knowledge integration at an abstraction level, it outperforms the state-of-the-art predictors by 6%. Besides the overall enhanced prediction performance, the convolutional neural network module embedded in iDeep is also able to automatically capture the interpretable binding motifs for RBPs. Large-scale experiments demonstrate that these mined binding motifs agree well with the experimentally verified results, suggesting iDeep is a promising approach in the real-world applications.ConclusionThe iDeep framework not only can achieve promising performance than the state-of-the-art predictors, but also easily capture interpretable binding motifs. iDeep is available athttp://www.csbio.sjtu.edu.cn/bioinf/iDeep
Constitutive Immune Activity Promotes Tumorigenesis inDrosophilaIntestinal Progenitor Cells
Authors: Petkau Kristina , Ferguson Meghan , Guntermann Silvia , Foley Edan 
Published: November 2016

SUMMARYGut innate immune defenses contain bacterial populations and protect the host interior from invasive microbes. Although excess intestinal immune activity frequently promotes inflammatory illnesses, we know little about the consequences of chronic innate immune activity exclusively in endodermal gut cells of an otherwise normal animal. To address this question, we generated a transgenic line that allows us to activate inflammatory signals in adult fly intestinal progenitor cells. We found that constitutive immune activity in intestinal progenitors disrupts expression of homeostatic regulators such as Notch signal transduction pathway components and induces hyperplasia throughout the gut. Consistent with these observations, we found that persistent immune signaling interferes with progenitor cell differentiation and exacerbates the formation of Notch-dependent intestinal tumors. These findings uncover a novel link between constitutive immune activity and tumorigenesis in intestinal stem cells.
“Negotiating partnerships:” parents’ experiences of collaboration in community mental health and substance use services
Authors: Ness Ottar , Borg Marit , Semb Randi , Topor Alain 
Published: November 2016

Purpose
The importance of collaboration in the mental health field is a well established theoretical principle, but there has so far been less attention to its practical implications from a parents’ perspective. The purpose of this paper is to describe parents’ experiences of collaboration with mental health practitioners.

Design/methodology/approach
This was a qualitative study based on thematic analysis of multi-stage focus group discussions with ten parents of young adults with co-occurring mental health and substance use problems.

Findings
The authors identified three major themes related to family member’s experiences of collaborative practices: negotiating partnerships, incomprehensible services and being the young adult’s advocate.

Research limitations/implications
A potential limitation of this study is that the parents who agreed to take part in this study were all part of the population who really want to be involved in their relative’s care; other family members who did not take part may have different feelings. It would be interesting to interview the siblings and partners of young adults with mental health and substance abuse problems. A last limitation is that only family parents participated in these focus group discussions; it would be interesting to invite service users and practitioners to elicit information about similarities and differences in their experiences of collaborative practices.

Practical implications
This study emphasises that parents should be seen as unique individuals as well as families. Parents are persons in different contexts. This creates different needs in their collaboration with the professionals. Parents want to be invited to contribute with their experiences and knowledge, being a collaborative partner in the service provision, and not a burden for their young adults, or to the professionals.

Social implications
This study emphasises that it may be important to understand the complex situations of each family parent, supporting their loved ones and at the same time living lives of their own. Families are in demanding and stressful situations often over many years. They want to be invited to contribute with their experiences and knowledge, being a collaborative partner in the service provision, and not a burden for their young adults, or to the professionals.

Originality/value
The importance of collaboration is well established in in the mental health field. However, there has been less attention to what collaboration with parents might involve in practice. This paper describes the collaborative experiences of parents of young adults (18-28 years) with co-occurring mental health and substance use problems.
Stochastic synchronization of neutral-type chaotic impulse neural networks with leakage delay and Markovian jumping parameters
Authors: Zheng Cheng-De , Wang Zhanshan 
Published: November 2016

Purpose
The purpose of this paper is to develop a methodology for the stochastically asymptotic synchronization problem for a class of neutral-type chaotic neural networks with both leakage delay and Markovian jumping parameters under impulsive perturbations.

Design/methodology/approach
The authors perform drive-response concept and time-delay feedback control techniques to investigate a class of neutral-type chaotic neural networks with both leakage delay and Markovian jumping parameters under impulsive perturbations. New sufficient criterion is established without strict conditions imposed on the activation functions.

Findings
It turns out that the approach results in new sufficient criterion easy to be verified but without the usual assumption of the differentiability and monotonicity of the activation functions. Two examples show the effectiveness of the obtained results.

Originality/value
The novelty of the proposed approach lies in removing the usual assumption of the differentiability and monotonicity of the activation functions, and the use of the Lyapunov functional method, Jensen integral inequality, a novel Gu’s lemma, reciprocal convex and linear convex combination technique for the stochastically asymptotic synchronization problem for a class of neutral-type chaotic neural networks with both leakage delay and Markovian jumping parameters under impulsive perturbations.
The global REIT market: initial-day performance of IPOs
Authors: Brobert Gustav 
Published: November 2016

PurposeThis paper aims to investigate whether real estate investment trust (REIT) initial public offerings (IPOs) are exposed to abnormal initial-day performance. Previous studies have predominantly focused on REITs listed in the USA and Australia, only a few studies have utilised a multi-country approach and only one study has used a multi-region approach. This paper adds to the literature by, for a global sample, analysing variables proven important in explaining REIT IPO performance but never used in a global sample before by extending the investigation of initial-day return patterns for new REIT types and by offering the first insights from emerging REIT markets.Design/methodology/approachInitial-day raw and abnormal returns were calculated for a sample of 445 IPOs in 26 countries over the period from 1996 to 2014. The returns were partitioned according to a select set of themes and multiple regression analysis was used to isolate the relationship between the explanatory factors and underpricing.FindingsFor the sample as a whole, the mean initial-day raw return is 3.94 per cent and the mean market-adjusted initial-day return is 4.01 per cent. Even though the initial-day return for a REIT IPO typically is positive, negative mean returns are observed for a few countries and during certain years. Investors should note that for European markets, new property type exhibited a robust positive association with abnormal return, and underwriter reputation exhibited a robust negative relationship with abnormal return.Originality/valueThis paper fulfils the need to test important concepts on global REIT IPO markets.
Searching and sourcing online academic literature
Authors: Hsin Ching-Ting , Cheng Ying-Hsueh , Tsai Chin-Chung 
Published: November 2016

Purpose
The purpose of this paper is to explore educational researchers’ online literature searching and sourcing strategies.

Design/methodology/approach
Adopting a multiple-case study approach, the authors conducted interviews and compared strategies employed by three groups of researchers: less-experienced doctoral students, experienced doctoral students, and junior faculty.

Findings
The results showed that the three groups differed in four searching strategies and two sourcing strategies. The former included: using and modifying keywords, doing advanced searches to narrow down or expand results, chaining, and networking to retrieve literature, while the latter consisted of: evaluating and selecting multiple-source articles, and self-monitoring the multiple-source searching process. The findings also revealed that the experienced doctoral students and junior faculty were able to adopt searching and sourcing strategies flexibly and simultaneously for the purpose of determining more relevant and useful sources. The findings suggest that these researchers, especially the less-experienced students, need specialized training to acquire sourcing strategies in order to critically evaluate relevant information or scholarly work to fulfill their research purposes.

Originality/value
Information seeking, an essential part of scholars’ work, has been widely examined across disciplines. However, few studies have explored scholars’ searching and sourcing behaviors for online academic literature. This study fulfilled the research gap.
Naltrexone changes the expression of lipid metabolism‐related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice
Authors: Moslehi Azam , Nabavizadeh Fatemeh , Zekri Ali , Amiri Fatemeh 
Published: November 2016

SummaryEndoplasmic reticulum (ER) stress is closely associated with several chronic diseases such as obesity, atherosclerosis, type 2 diabetes, and hepatic steatosis. Steatosis in hepatocytes may also lead to disorders such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), fibrosis, and possibly cirrhosis. Opioid peptides are involved in triglyceride and cholesterol dysregulation. Naltrexone also attenuates ER stress induced hepatic steatosis in mice. In this study, we evaluated the effects of naltrexone on the expression of lipid metabolism‐related nuclear factors and enzymes in the ER stress induced hepatic steatosis. C57/BL6 mice received saline, DMSO and naltrexone as control groups. In a fourth group, ER stress was induced by tunicamycin (TM) injection and in the last group, naltrexone was given before TM administration. Histopathological evaluations, real‐time RT‐PCR and western blot were performed. We found that GRP78, IRE1α, PERK and ATF6 gene expression and steatosis significantly reduced in naltrexone treated animals. Naltrexone alleviated the gene and protein expression of SREBP1c. Expression of ACAT1, apolipoprotein B (ApoB) and PPARα also increased after naltrexone treatment. In conclusion, this study, for the first time, shows that naltrexone has a considerable role in attenuation of ER stress‐induced liver injury.
Family social capital and health – a systematic review and redirection
Authors: Alvarez Elena Carrillo , Kawachi Ichiro , Romani Jordi Riera 
Published: November 2016

AbstractThe level (or scale) at which social capital can be conceptualised and measured ranges potentially from the macro‐level (regional or country level), to the meso‐level (neighbourhoods, workplaces, schools), down to the individual level. However, one glaring gap in the conceptualisation of social capital within the empirical literature has been the level of the family. Our aim in this review is to examine the family as the ‘missing level’ in studies on social capital and health. To do so, we conducted a systematic review on the use and measurement of this notion in the health literature, with the final intention of articulating a direction for future research in the field. Our findings are consistent with the notion that family social capital is multidimensional and that its components have distinct effects on health outcomes. Further investigation is needed to understand the mechanisms through which family social capital is related to health, as well as determining the most valid ways to measure family social capital.
The Political Economy of Fiscal Supervision and Budget Deficits: Evidence from Germany
Authors: Rösel Felix 
Published: November 2016

AbstractIn many federal countries, local governments run large deficits, even when fiscal supervision by state authorities is tight. I investigate the extent to which party alignment of governments and fiscal supervisors influences budget deficits. The data set includes 427 German local governments for the period 2000–2004. I exploit a period after a far‐reaching institutional reform that entirely re‐distributed political powers on both the government level and the fiscal supervisor level. The results do not show that party alignments of governments and supervisors (co‐partisanship) drive short‐term deficits. Instead, I find that the ideology of partisan governments and supervisors matters: left‐wing local governments run higher deficits than their right‐wing counterparts; left‐wing supervisors tolerate higher deficits than right‐wing supervisors. These findings imply that political independence for fiscal supervisors is recommended.
Controlling for P‐value inflation in allele frequency change in experimental evolution and artificial selection experiments
Authors: Kemppainen Petri , Rønning Bernt , Kvalnes Thomas , Hagen Ingerid J. , Ringsby Thor Harald , Billing Anna M. , Pärn Henrik , Lien Sigbjørn , Husby Arild , Sæther Bernt‐Erik , Jensen Henrik 
Published: November 2016

AbstractExperimental evolution studies can be used to explore genomic response to artificial and natural selection. In such studies, loci that display larger allele frequency change than expected by genetic drift alone are assumed to be directly or indirectly associated with traits under selection. However, such studies report surprisingly many loci under selection, suggesting that current tests for allele frequency change may be subject to P‐value inflation and hence be anticonservative. One factor known from genomewide association (GWA) studies to cause P‐value inflation is population stratification, such as relatedness among individuals. Here, we suggest that by treating presence of an individual in a population after selection as a binary response variable, existing GWA methods can be used to account for relatedness when estimating allele frequency change. We show that accounting for relatedness like this effectively reduces false‐positives in tests for allele frequency change in simulated data with varying levels of population structure. However, once relatedness has been accounted for, the power to detect causal loci under selection is low. Finally, we demonstrate the presence of P‐value inflation in allele frequency change in empirical data spanning multiple generations from an artificial selection experiment on tarsus length in two free‐living populations of house sparrow and correct for this using genomic control. Our results indicate that since allele frequencies in large parts of the genome may change when selection acts on a heritable trait, such selection is likely to have considerable and immediate consequences for the eco‐evolutionary dynamics of the affected populations.