bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elucidating a statistical learning brain network: Coordinate-based meta-analyses and functional connectivity profiles of artificial grammar learning in healthy adults
Authors: Ramage Amy E. , Cote Kaila , Thorson Jill C. , Lerner Katelyn , Reidel Michael C. , Laird Angela R. 
Published: October 2024

Abstract
Language rehabilitation centers on modifying its use through experience-based neuroplasticity. Statistical learning of language is essential to its acquisition and likely its rehabilitation following brain injury, but its corresponding brain networks remain elusive. Coordinate-based meta-analyses were conducted to identify common and distinct brain activity across 25 studies coded for meta-data and experimental contrasts (Grammatical and Ungrammatical). The resultant brain regions served as seeds for profiling functional connectivity in large task-independent and task-dependent data sets. Hierarchical clustering of these profiles grouped brain regions into three subnetworks associated with statistical learning processes. Functional decoding clarified the mental operations associated with those subnetworks. Results support a left-dominant language sub-network and two cognitive control networks as scaffolds for language rule identification, maintenance, and application in healthy adults. These data suggest that cognitive control is necessary to track regularities across stimuli and imperative for rule identification and application of grammar. Future empirical investigation of these brain networks for language learning in individuals with brain injury will clarify their prognostic role in language recovery.
LncRNA NRIR serves as a biomarker for systemic lupus erythematosus and participates in the disease progression
Authors: Ma Qingfeng , Li Li , Xing Youzhong 
Published: October 2024

Background Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by a malfunction of the body’s immune defense system. Objective The objective of the present investigation was to examine the expression and diagnostic significance of NRIR in SLE and to prove whether it is involved in the progression of SLE. Methods The study involved 110 participants, including 55 healthy individuals and 55 SLE patients. The expression levels of NRIR, miR-31-5p, and ICAM-1 were measured using qRT-PCR. The ROC curve was performed to assess the diagnostic significance of NRIR in SLE patients. Pearson correlation analysis was utilized to explore the relationship between NRIR and other indicators. Cytokines including IL-4, IL-6, and IL-21, along with IgG levels, were assessed using ELISA. The interaction between NRIR and miR-31-5p was validated using a dual-luciferase reporter assay. Result Upregulated expression of NRIR was observed in individuals with SLE, serving a diagnostic function for SLE. Additionally, abnormal expression of NRIR impacted the viability of CD4+ T cells within SLE patients. NRIR could negatively modulate the expression of miR-31-5p. Conclusion LncRNA NRIR may be a potential biomarker for SLE and is likely involved in the progression of SLE.
Getting time and building trust: unveiling the systemic, relational, and personal factors influencing clinical pharmacy service implementation in South Africa, a qualitative study
Authors: Crafford Lucille , Kusurkar Rashmi A , Bronkhorst Elmien , Gous Andries , Wouters Anouk 
Published: October 2024

Abstract
Background
While multidisciplinary teams with clinical pharmacists improve medication use and outcomes, their integration in South Africa faces limitations. A lack of dedicated positions and healthcare professionals’ misunderstanding restrict ward activities and hinder full collaboration, limiting their potential to optimize patient care. This study addresses a gap by exploring how perceived healthcare professionals’ understanding of clinical pharmacists’ roles impacts their motivation and service implementation. Understanding these dynamics, particularly in resource-constrained settings, is crucial for optimizing integration and healthcare delivery.

Methods
Adopting a constructivist approach, this qualitative study was conducted using focus group discussions. Through purposive sampling clinical pharmacists were recruited across South Africa’s public healthcare sector. A semi-structured guide based on previous findings explored how the perceived understanding around clinical pharmacy impacts service delivery and work motivation. Transcripts were analyzed using thematic analysis, guided by the Self-Determination Theory framework. Thematic analysis employed an inductive approach, following an initial preliminary analysis of open and selective coding to develop a coding framework.

Results
Clinical pharmacists (n = 16) reported various challenges impacting service implementation and motivation. Two main themes were identified: (1) Time: Dedicated ward time is crucial for both the proper implementation of clinical services, as well as the clinical pharmacists’ motivation; and (2) Trust: Clinical pharmacists experience a lack of trust amongst healthcare professionals in the value of clinical pharmacy services. The themes illustrated mechanisms at work at three levels: systemic (lack of dedicated positions), inter-relational (healthcare professional’s misconceptions), and personal (thwarted autonomy).

Conclusions
Systemic challenges, like the absence of official positions present the biggest obstacle, affecting support, scope of practice, and healthcare professional interactions. While systemic changes are crucial for full integration of clinical pharmacists, in resource-constrained settings fostering autonomous motivation is equally important. This study emphasizes the need for a multi-faceted approach, including policy changes, international collaboration, interprofessional education, and interventions to empower clinical pharmacists for proactive service delivery. By addressing these interconnected challenges, healthcare systems can leverage the full potential of clinical pharmacists, ultimately improving healthcare delivery and patient outcomes.
Spatial-transcriptomic profiling: a new lens for understanding myelofibrosis pathophysiology
Authors: Peroni Edoardo , Calistri Elisabetta , Amato Rosario , Gottardi Michele , Rosato Antonio 
Published: October 2024

AbstractMyelofibrosis (MF) is a complex myeloproliferative neoplasm characterized by abnormal hematopoietic stem cell proliferation and subsequent bone marrow (BM) fibrosis. First documented in the late 19th century, MF has since been extensively studied to unravel its pathophysiology, clinical phenotypes, and therapeutic interventions. MF can be classified into primary and secondary forms, both driven by mutations in genes such as JAK2, CALR, and MPL, which activate the JAK-STAT signaling pathway. These driver mutations are frequently accompanied by additional non-driver mutations in genes like TET2, SRSF2, and TP53, contributing to disease complexity. The BM microenvironment, consisting of stromal cells, extracellular matrix, and cytokines such as TGF-β and TNF-α, plays a critical role in fibrosis and aberrant hematopoiesis. Clinically, MF manifests with symptoms ranging from anemia, splenomegaly, and fatigue to severe complications such as leukemic transformation. Splenomegaly, caused by extramedullary hematopoiesis, leads to abdominal discomfort and early satiety. Current therapeutic strategies include JAK inhibitors like Ruxolitinib, which target the JAK-STAT pathway, alongside supportive treatments such as blood transfusions, erythropoiesis-stimulating agents and developing combinatorial approaches. Allogeneic hematopoietic stem cell transplantation remains the only curative option, though it is limited to younger, high-risk patients. Recently approved JAK inhibitors, including Fedratinib, Pacritinib, and Momelotinib, have expanded the therapeutic landscape. Spatially Resolved Transcriptomics (SRT) has revolutionized the study of gene expression within the spatial context of tissues, providing unprecedented insights into cellular heterogeneity, spatial gene regulation, and microenvironmental interactions, including stromal-hematopoietic dynamics. SRT enables high-resolution mapping of gene expression in the BM and spleen, revealing molecular signatures, spatial heterogeneity, and pathological niches that drive disease progression. These technologies elucidate the role of the spleen in MF, highlighting its transformation into a site of abnormal hematopoietic activity, fibrotic changes, and immune cell infiltration, functioning as a “tumor surrogate.” By profiling diverse cell populations and molecular alterations within the BM and spleen, SRT facilitates a deeper understanding of MF pathophysiology, helping identify novel therapeutic targets and biomarkers. Ultimately, integrating spatial transcriptomics into MF research promises to enhance diagnostic precision and therapeutic innovation, addressing the multifaceted challenges of this disease.
Mapping the glial transcriptome in Huntington’s disease using snRNAseq: selective disruption of glial signatures across brain regions
Authors: Bøstrand Sunniva M. K. , Seeker Luise A. , Bestard-Cuche Nadine , Kazakou Nina-Lydia , Jäkel Sarah , Kenkhuis Boyd , Henderson Neil C. , de Bot Susanne T. , van Roon-Mom Willeke M. C. , Priller Josef , Williams Anna 
Published: October 2024

AbstractHuntington’s disease (HD) is an autosomal dominant neurodegenerative disease with a fatal outcome. There is accumulating evidence of a prominent role of glia in the pathology of HD, and we investigated this by conducting single nuclear RNA sequencing (snRNAseq) of human post mortem brain in four differentially affected regions; caudate nucleus, frontal cortex, hippocampus and cerebellum. Across 127,205 nuclei from donors with HD and age/sex matched controls, we found heterogeneity of glia which is altered in HD. We describe prominent changes in the abundance of certain subtypes of astrocytes, microglia, oligodendrocyte precursor cells and oligodendrocytes between HD and control samples, and these differences are widespread across brain regions. Furthermore, we highlight possible mechanisms that characterise the glial contribution to HD pathology including depletion of myelinating oligodendrocytes, an oligodendrocyte-specific upregulation of the calmodulin-dependent 3’,5’-cyclic nucleotide phosphodiesterase 1 A (PDE1A) and an upregulation of molecular chaperones as a cross-glial signature and a potential adaptive response to the accumulation of mutant huntingtin (mHTT). Our results support the hypothesis that glia have an important role in the pathology of HD, and show that all types of glia are affected in the disease.
DroneSilient (drone + resilient): an anti-drone system
Authors: Nair Meghna Manoj , Sriraman Harini , Sai Gadiparthy Harika , Pattabiraman V. 
Published: October 2024

AbstractIt is imperative to take a holistic strategy to thwarting drone threats, including the identification of drones and drone-like gadgets like ornithopters that visually imitate birds. In this study, we present the DroneSilient System, a novel anti-drone system that combines different parts. The DroneSilient system includes components that connect to RF identification technology and image-capture technology. A modified bloom filter method is used to further identify the recognized object after a drone-like object has been found, allowing for the differentiation between regular drones, ornithopters, and genuine birds. The CNN (Convolutional Neural Network) method, created using the Google Cloud Platform and AutoML widget, is used in our model for object identification and categorization. DroneSilient has an RF sensor that can identify and imitate the threat presented by recognized drones. Convolutional Network, Modified Blooms Algorithm, RFID, and RF Sensor systems are all integrated into the DroneSilient system as part of this methodology combination, which provides a thorough method for identifying and eliminating drone threats. The bloom filter proposed takes 27.6 to 12.4 microseconds. Overall time for handling the unauthorized drone will be less than 180 s. By tackling every facet of the problem, our strategy outperforms many current anti-drone solutions in terms of functionality.
Pharmacological interventions for co-occurring psychopathology in people with borderline personality disorder: secondary analysis of the Cochrane systematic review with meta-analyses
Authors: Pereira Ribeiro Johanne , Juul Sophie , Kongerslev Mickey T. , Jørgensen Mie Sedoc , Völlm Birgit A , Edemann-Callesen Henriette , Sales Christian , Schaug Julie P. , Lieb Klaus , Simonsen Erik , Stoffers-Winterling Jutta M. , Storebø Ole Jakob 
Published: October 2024

Background
Medications are commonly used to treat co-occurring psychopathology in persons with borderline personality disorder (BPD)

Aims
To systematically review and integrate the evidence of medications for treatment of co-occurring psychopathology in people with BPD, and explore the role of comorbidities.

Method
Building on the current Cochrane review of medications in BPD, an update literature search was done in March 2024. We followed the methods of this Cochrane review, but scrutinised all identified placebo-controlled trials post hoc for reporting of non BPD-specific (‘co-occurring’) psychopathology, and explored treatment effects in subgroups of samples with and without defined co-occurring disorders. GRADE ratings were done to assess the evidence certainty.

Results
Twenty-two trials were available for quantitative analyses. For antipsychotics, we found very-low-certainty evidence (VLCE) of an effect on depressive symptoms (standardised mean difference (SMD) −0.22, P = 0.04), and low-certainty evidence (LCE) of an effect on psychotic–dissociative symptoms (SMD −0.28, P = 0.007). There was evidence of effects of anticonvulsants on depressive (SMD −0.44, P = 0.02; LCE) and anxious symptoms (SMD −1.11, P < 0.00001; VLCE). For antidepressants, no significant findings were observed (VLCE). Exploratory subgroup analyses indicated a greater effect of antipsychotics in samples including participants with co-occurring substance use disorders on psychotic–dissociative symptoms (P = 0.001).

Conclusions
Our findings, based on VLCE and LCE only, do not support the use of pharmacological interventions in people with BPD to target co-occurring psychopathology. Overall, the current evidence does not support differential treatment effects in persons with versus without defined comorbidities. Medications should be used cautiously to target co-occurring psychopathology.
Effect of Prednisone Dosing on Mineralocorticoid-Related Side Effects With Abiraterone in Prostate Cancer
Authors: Goryachok Maksym , Nicklawsky Andrew , Ahmad Hiba , Geiger Christopher , Kim Simon , Flaig Thomas W. 
Published: October 2024

PURPOSE
Abiraterone use for prostate cancer can cause mineralocorticoid excess syndrome (MES; eg, hypertension and hypokalemia). Prednisone mitigates these effects; however, the optimal dose level is unclear. This study examines MES effects from abiraterone with 5 mg of prednisone once daily versus 5 mg twice daily.

METHODS
Data for 1,410 abiraterone-treated patients from 2011 to 2022 were identified from a large academic/community hospital system. Three hundred and fifty-three patients were excluded for missing medication data and use of an alternative steroid; 1,057 patients remained (5 mg once daily, n = 550, 5 mg twice daily, n = 507). Prednisone dose was treated as a time-varying covariate. Hypokalemia and hypertension incidence over 24 weeks after abiraterone initiation was analyzed via Cox proportional hazard models using Common Terminology Criteria for Adverse Events (v5.0) grading via direct clinical measurements and International Classification of Diseases (ICD)-10 code outcomes.

RESULTS

Patients receiving 5 mg of prednisone twice daily had a statistically significant decrease in cumulative hazard for experiencing at least one MES event (hypertension and/or hypokalemia) via direct clinical measurement (hazard ratio [HR], 0.79 [CI, 0.68 to 0.91];
P
= .002) and by ICD-10 code (HR, 0.65 [CI, 0.54 to 0.79];
P
< .001) analysis. This finding was durable with individual end point analysis of hypertension and hypokalemia. There were no changes to BMI or hyperglycemia (>140 mg/dL) between the cohorts.

CONCLUSION
This retrospective analysis shows a decrease in risk for the development of at least one episode of hypertension or hypokalemia with abiraterone using 5 mg twice-daily prednisone in the study population. Assessments of metabolic impacts (BMI, hyperglycemia) did not show differences with prednisone dosing. These findings may merit consideration when determining an optimal prednisone dosing regimen.
Imogen Binnie's Unreliable Narrators
Authors: Grossman Jonathan H. 
Published: October 2024

Abstract
This essay makes the case that Binnie has crafted an unreliable narrator in the 2012 short story “I Met a Girl Named Bat Who Met Jeffrey Palmer,” and it then extends that argument to her 2013 novel Nevada. The literary device of the unreliable narrator has long been, and continues to be, entangled with the status of bodies, racialized, colonized, sexualized, neurodiverse, gendered, age categorized, and so on. My contention is that Binnie ought to be recognized for the way she claims the fictional device of the unreliable narrator for a modern US trans context. As this essay contends, Nevada may depict the experiences of being trans in all kinds of insightful ways, but it makes the comic absurdity of ever adequately creating a reliable framework to explicate being trans into its structuring starting point. In developing the unreliable narrator as a riposte to trans legibility, Binnie's fiction instances what Grace Lavery calls “trans realism.”
Lacanian Anxieties
Authors: Lovett Matthew 
Published: October 2024

Abstract
This essay argues that Lacanian psychoanalysis and trans studies can indeed accommodate each other rather than appear incommensurable. It first acknowledges the problem of Lacanian transphobia via the recent work of Slavoj Žižek and Jacques-Alain Miller, and organizes their arguments around three related psychoanalytic concerns: demand, desire, and the real of sexual difference. In showing how Žižek and Miller orient their arguments around these axes, the author shows that they misread trans subjects solely as subjects of demand, as those who refuse to cope with, and instead misrecognize or cancel, the real of sexual difference. After indicating the role of countertransference in these interpretations, the author then turns to accounts from trans persons and trans affirmative Lacanians to resituate trans subjects as subjects of desire rather than of demand. This shows requests for trans medical care to be in the name of facilitating, rather than stopping, desire.
Rethinking Trans Trajectories via Life History
Authors: Lewis Vek 
Published: October 2024

Abstract
This article provides a life history analysis of Pepa Moreno, a transgender individual from Puebla, Mexico. The life events that she narrated in the interview conducted at her home and business—her move out of street sex work and her start as a business and property owner—offer a glimpse into the intertwining of personal/familial history and the processes unfolding in the spaces of society and economy. The article employs a critical realist framework around identity, based on life history as method, setting the scene around major restructurings of economy that private property regimes, urban transformation, morphing class realities, and capital investment (under neoliberalism) effected over her life: from adolescence into middle age. These transformations conjugate with changes across Pepa's own trajectory; key here are the meanings of “legitimate” work and moral worth that lie at the heart of the moral-legal economies that trans people in town, especially of working-class backgrounds, must confront. Labor status and class deeply intersect with a remaking of herself, which culminates with her naming herself as transgender once she has established herself as property owner and businessperson. However, even while invoking this category, she does not use it in line with the activist and sexological discourses that arose from the late 1990s on in Mexico City and which became prominent in Puebla in the early 2000s. The article thus maps the changing positions—and positionalities—of Pepa, examining the dialectics between lived experience and social structure, and the spaces of agency achieved through identity work.
Initial Symptom Severity and Recovery of Sport-Related Concussion in Team Versus Individual Sport Athletes
Authors: Long Connor C. , Dugan John E. , Jo Jacob , Williams Kristen L. , Jonzzon Soren , Terry Douglas P. , Yengo-Kahn Aaron M. , Zuckerman Scott L. 
Published: October 2024

BACKGROUND AND OBJECTIVES:
Recovery after sport-related concussion is variable, and potential differences between team vs individual sport athletes are not fully understood. In a cohort of athletes with concussions, we sought to compare these groups across (1) symptom severity score, (2) individual symptom cluster scores, and (3) recovery metrics.

METHODS:
A retrospective, cohort study of 13 to 23-year-old athletes treated at a regional sport concussion center between November 2017 and April 2022 was conducted. Athletes were categorized into team vs individual sport athletes, with additional classification of individual sports based on strong vs minimal team elements (ie, the degree of interdependence displayed by athletes). The primary outcomes were symptom severity score, measured by either the Sport Concussion Assessment Tool-5th Edition or the Immediate Post-Concussion Assessment and Cognitive Testing, and physical, cognitive, emotional, and sleep symptom cluster scores. Secondary outcomes were recovery metrics, including time to return-to-learn, symptom resolution, and return-to-play.

RESULTS:
Of the 1051 athletes, 954 (90.8%) were in team sports and 97 (9.2%) in individual sports. In multivariable linear regression, individual sport athletes had higher emotional symptom severity compared with team sport athletes (β = 0.09 [0.01, 0.17], P = .034) when adjusting for sex, attention-deficit/hyperactivity disorder, psychological disorders, time to clinic, on-field evaluation, and Immediate Post-Concussion Assessment and Cognitive Testing vs Sport Concussion Assessment Tool-5th Edition scale. There were no significant differences in return-to-learn (P = .104), symptom resolution (P = .941), or return-to-play (P = .279) on univariate regressions.

CONCLUSION:
In the current single-center, pilot study of athletes with a sport-related concussion, individual sport athletes exhibited more emotional symptoms than team sport athletes. These preliminary data lend early support that individual sport athletes may be more at risk of emotional symptoms than team sport athletes after a sport-related concussion. Clinicians may use these findings to identify athletes who may be particularly vulnerable to emotional symptoms.