bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radial and ulnar fracture treatment with paraosseous clamp‐cerclage stabilisation technique in 17 toy breed dogs
Authors: Manchi George , Brunnberg Mathias M , Shahid Muhammad , Al Aiyan Ahmad , Chow Eric , Brunnberg Leo , Stein Silke 
Published: May 2017

ObjectiveDescription of surgical technique, complications and outcome of radius/ulna fractures in toy and miniature breed dogs treated with the paraosseous clamp‐cerclage stabilisation (PCCS) method.Study designRetrospective study.MethodsClinical records of small breed dogs with fractures of the radius and ulna were reviewed between January 2011 and January 2016. Inclusion criteria were bodyweight of ≤3.5 kg, fracture of the radius and ulna of one or two limbs without previous repair attempts, available follow‐up information, and the use of PCCS for repair of the fracture as the sole method of fixation.ResultsSeventeen fractures in 17 dogs were included in the study. Radiographic union was documented in 13/17 cases. Median time to radiographic union was 13 weeks (range: 5–53 weeks). Major complications occurred in 24 per cent (4/17) due to implant failure, and for revision surgery the PCCS method was chosen in all four cases. Three of four revised fractures healed radiographically. One of the four dogs was lost for radiographic follow‐up, but the owner could be contacted for a telephone questionnaire. Eleven of 17 dogs achieved an excellent return to function without any lameness during clinical examination, but 5/17 dogs showed an intermittent mild lameness despite full radiographic union. Routine implant removal was performed in 9/17 dogs. The owners of 15/17 dogs could be contacted for a telephone questionnaire for a long‐term follow‐up. No further complications were reported.ConclusionsPCCS is a feasible low‐cost internal fixation technique for repairing radial and ulnar fractures in toy breed dogs. Further biomechanical and clinical studies are needed for better evaluation of the PCCS method.
The dependence of critical current density of GdFeCo layer on composition of thermally assisted STT-RAM
Authors: Dai B. , Zhu J. , Liu K. , Yang L. , Han J. 
Published: May 2017

Amorphous rare earth–transitional metal (RETM) GdFeCo memory layer with RE- and TM-rich compositions was fabricated in stacks of GdFeCo (10 nm)/Cu (3 nm)/[Co(0.2 nm)/Pd(0.4 nm)]6. Their magnetic properties and spin transfer torque (STT) switching of magnetization were investigated. The maximum magneto-resistance (MR) was around 0.24% for the TM-rich Gd[Formula: see text] (Fe[Formula: see text]Co[Formula: see text])[Formula: see text] memory layer and was −0.03% for the RE-rich Gd[Formula: see text] (Fe[Formula: see text]Co[Formula: see text])[Formula: see text] memory layer. The critical current densities [Formula: see text] to switch the GdFeCo memory layers are in the range of [Formula: see text] A/cm2–[Formula: see text] A/cm2. The dependence of critical current density [Formula: see text] and effective anisotropy constant [Formula: see text] on Gd composition were also investigated. Both [Formula: see text] and [Formula: see text] have maximum values in the Gd composition range from 21–29 at.%, suitable for thermally assisted STT-RAM for storage density exceeding Gb/inch2.
Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis—Brief Report
Authors: Konaniah Eddy S. , Kuhel David G. , Basford Joshua E. , Weintraub Neal L. , Hui David Y. 
Published: May 2017

Objective—

Mice with adipocyte-specific inactivation of low-density lipoprotein receptor–related protein-1 (LRP1) are resistant to diet-induced obesity and hyperglycemia because of compensatory thermogenic response by muscle. However, the physiological function of LRP1 in mature adipocytes and its role in cardiovascular disease modulation are unknown. This study compared perivascular adipose tissues (PVAT) from wild-type (
adLrp1
+/+
) and adipocyte-specific LRP1 knockout (
adLrp1
−/−
) mice in modulation of atherosclerosis progression.

Approach and Results—

Analysis of adipose tissues from
adLrp1
+/+
and
adLrp1
−/−
mice after Western diet feeding for 16 weeks revealed that, in comparison to
adLrp1
+/+
mice, the adipocytes in
adLrp1
−/−
mice were smaller, but their adipose tissues were more inflamed with increased monocyte–macrophage infiltration and inflammatory gene expression. The transplantation of PVAT from chow-fed
adLrp1
+/+
and
adLrp1
−/−
mice into the area surrounding the carotid arteries of
Ldlr
−/−
mice before feeding the Western diet revealed a contributory role of PVAT toward hypercholesterolemia-induced atherosclerosis. Importantly, recipients of
adLrp1
−/−
PVAT displayed a 3-fold increase in atherosclerosis compared with
adLrp1
+/+
PVAT recipients. The increased atherosclerosis invoked by LRP1-deficient PVAT was associated with elevated monocyte–macrophage infiltration and inflammatory cytokine expression in the transplanted fat.

Conclusions—
PVAT provide outside-in signals through the adventitia to modulate atherosclerotic lesion progression in response to hypercholesterolemia. Moreover, adipocytes with LRP1 deficiency are dysfunctional and more inflamed. This latter observation adds the adipose tissue to the list of anatomic sites where LRP1 expression is important to protect against diet-induced atherosclerosis.
Initiation Patterns of Statins in the 2 Years After Release of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) Cholesterol Management Guideline in a Large US Health Plan
Authors: Olufade Temitope , Zhou Siting , Anzalone Deborah , Kern David M. , Tunceli Ozgur , Cziraky Mark J. , Willey Vincent J. 
Published: May 2017

Background

The purpose of this study was to characterize changes in statin utilization patterns in patients newly initiated on therapy in the 2 years following the release of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol management guideline in a large
US
health plan population.

Methods and Results

This retrospective, observational study used administrative medical and pharmacy claims data to identify patients newly initiated on statin therapy over 4 quarters prior to and 8 quarters following the release of the guideline (average N/quarter=3596). Patients were divided into the 4 statin benefit groups (
SBG
s) based on risk factors and laboratory lipid levels as defined in the guideline:
SBG
1 (with atherosclerotic cardiovascular disease [
ASCVD
]; N=1046/quarter),
SBG
2 (without
ASCVD
, with low‐density lipoprotein cholesterol ≥190 mg/dL; N=454/quarter),
SBG
3 (without
ASCVD
, aged 40–75 years, with diabetes mellitus, low‐density lipoprotein cholesterol 70–189 mg/dL; N=1391/quarter),
SBG
4 (no
ASCVD
or diabetes mellitus, age 40–75 years, low‐density lipoprotein cholesterol 70–189 mg/dL, estimated 10‐year
ASCVD
risk of ≥7.5%; N=705/quarter). Demographic variables, statin utilization patterns, lipid levels, and comorbidities were analyzed for pre‐ and postguideline periods. Postguideline, gradually increased high‐intensity statin initiation occurred in
SBG
1,
SBG
2, and in
SBG
3 patients with 10‐year
ASCVD
risk ≥7.5%. Moderate‐ to high‐intensity statin initiation gradually increased among
SBG
4 patients. Recommended‐intensity statin choice changed to a greater degree among patients treated by specialty care physicians. Regarding sex, target‐intensity statin initiation was lower in women in all groups before and after guideline release.

Conclusions

Prescriber implementation of the guideline recommendations has gradually increased, with the most marked change in the increased initiation of high‐intensity statins in patients with
ASCVD
and in those treated by a specialist.
Predictors of failure of DISE-directed adenotonsillectomy in children with sleep disordered breathing
Authors: Alsufyani Noura , Isaac Andre , Witmans Manisha , Major Paul , El-Hakim Hamdy 
Published: May 2017

Background Adenotonsillectomy (AT) is the most commonly performed procedure for sleep disordered breathing (SDB) in pediatrics. However, 20-40% of patients will have persistent signs and symptoms of SDB after AT. Drug-induced sleep endoscopy (DISE) has the potential to individualize surgical treatments and avoid unnecessary or unsuccessful surgeries. The objective of this study was to determine the predictors of failure of DISE-directed adenoidectomy and/or tonsillectomy in otherwise healthy children with SDB. Methods We retrospectively reviewed a prospective database of children who presented with SDB. All patients underwent preoperative pulse oximetry (PO), followed by DISE with T ± A, The variables documented included demographics, ethnicity, co-morbidities, family history, McGill Oximetry Score (MOS) on PO, as well as findings of collapse and or obstruction on DISE and symptom resolution based on modified Pediatric Sleep Questionnaire (PSQ). The primary outcome was the independent predictors of treatment failure based on multivariate binary logistic regression. Results Three hundred eighty-two patients satisfied the inclusion criteria. Based on post-operative modified PSQ, SDB resolved in 259 patients (68%), whereas 123 (32%) had persistent symptoms. On bivariate analysis, neuropsychiatric diagnosis ( r = 0.286, p = 0.042), history of sleepwalking or enuresis ( r = 0.103, p = 0.044), MOS ( r = 0.123, p = 0.033), presence of DNS ( r = 0.107, p = 0.036), and presence of laryngomalacia ( r = 0.122, p = 0.017) all positively correlated with treatment failure. Small tonsil size on DISE correlated with treatment failure ( r = −0.180, p < 0.001). Multivariate analysis identified age greater than 7 years (OR = 1.799, [95% CI 1.040–3.139], p = 0.039), obesity (OR = 2.032, [95% CI 1.043–3.997], p = 0.040), chronic rhinitis (OR = 1.334, [95% CI 1.047–1.716], p = 0.025), deviated nasal septum (OR = 1.745, [95% CI 1.062–2.898], p = 0.031) and tonsil size (OR = 0.575, [95% CI 0.429–0.772], p < 0.01) as independent predictors of treatment failure. Conclusions Obese, asthmatic, and children older than seven years are at increased risk of treatment failure after DISE-directed AT. Several DISE findings can independently predict AT failure, including tonsil size, degree of chronic rhinitis, and the presence of a deviated nasal septum, and can be addressed at a second stage. Further research is needed into the role of DISE in surgically naïve patients with SDB, and to compare DISE-directed surgery with the current standard of care.
The cost-effectiveness of a novel soluble beta-glucan gel
Authors: Cutting K.F. 
Published: May 2017

Objective:Wounds that have stalled healing are costly in terms of patient morbidity and increase in use of material and financial resources. A natural polymer beta-glucans has been incorporated into a methylcellulose gel to provide a topical gel designed to accelerate healing in wounds where it has stalled. Although the gel provides an environment conducive to moist wound healing the active agent, beta-glucans, activate the innate immune response.Method:Using a Markov cohort simulation model, data were extrapolated from a double-blind randomised trial to evaluate the economic benefits of the soluble beta-glucan (SBG) gel in the treatment of diabetic foot ulcers (DFUs).Results:Over an annual budget cycle, SBG gel is expected to heal 94% of wounds compared with 78% when given standard care. It also healed wounds more quickly, with the average expected healed weeks 34.4 in the SBG gel group, compared with 24.7 methylcellulose dressing group. In our model this leads to a cost saving over an annual budget cycle of £503 per patient. Note: healed weeks refers to the number of weeks when the wound has healed during the 12-week period and should not be confused with weeks to healing.Conclusion:The shorter healing time associated with the SBG gel treatment leads to a cost saving because fewer weeks of treatment are required to heal the wound, suggesting this is a promising new cost-effective option for the treatment of DFUs.
Evaluation of skin perfusion pressure to assess refractory foot ulcers
Authors: Kawai M. , Mihara S. , Takahagi S. , Iwamoto K. , Hiragun T. , Hide M. 
Published: May 2017

Objective:The number of patients with foot gangrene caused by critical ischaemia and severe infection is increasing significantly in developed countries. The measurement of perilesional skin blood flow by skin perfusion pressure (SPP) is useful to select the appropriate treatment of gangrenous lesions, in that it is not affected by calcifications of blood vessels. However, the prognosis of a foot ulcer may also be affected by the level of blood sugar and infections. This study aimed to validate the use of SPP in cases of foot gangrene and ulcers in patients with and without diabetes mellitus (DM) and infection.Method:Clinical symptoms, ankle-brachial pressure index (ABPI) and SPP were assessed to evaluate the condition of each foot ulcer. Every foot ulcer was treated as independent, even if a participant had multiple ulcers. All ulcers for which we measured SPP were subject to the analysis. All ulcers were purely ischaemic in nature and were exclusively located on the foot or toes.Results:Data were collected from 117 foot ulcers on 91 toes and feet from 65 patients. Almost all SPP values in healed cases were > 27 mmHg. There were three patients whose ulcers failed to heal by conservative treatments were complicated with severe infection. However, no effect of DM on the relationship between SPP values and prognosis was observed. Logistic regression analysis of all ulcers except for the 5 cases complicated with infection revealed that those with 30 mmHg or lower SPP values are likely to heal by conservative treatment with 23% or lower probability, whereas any ulcer with more than 50 mmHg SPP value and without severe infection may heal without the need for further operations with 80% or higher probability.Conclusion:The combination of SPP and careful evaluation of infection may be a good parameter to decide the appropriate treatment for ischaemic skin ulcers, regardless of the complication of DM.
Classroom inside writing activities from perspective of pre-service teacher<p>Öğretmen adaylarının perspektifinden sınıf içi yazma çalışmalarının değerlendirilmesi
Authors: Ateş Seyit 
Published: May 2017

Writing, which is defined as a statement of thoughts, emotions, and knowledge in a writing form, is an important skill used by any individual during lifelong. Due to this fact, writing skill have drawn more attention from educators and researchers and a number of empiric and theoretical researches have been conducted on how to acquire and develop this skill. Additionally, how this skill is transferred into classroom setting has an interest. The current research aimed to explore the writing practices in the classroom settings from the pre-service teachers’ perspectives. This research employed qualitative case study method and the data was collected though the structured observations and semi-structured focus group interviews. The fourth-year pre-service teachers studying at elementary school classroom teaching and their experienced teachers in their student teaching experience schools constituted the research sample. The data was analyzed by using descriptive techniques. The overall findings of the research showed that there was a relative lack of the practice used for developing writing skills in the classroom setting. While the grade level changed, the practices for writing di not differentiated. Based on the research findings, the recommendations were given. Extended English abstract is in the end of PDF (TURKISH) file. ÖzetZihindeki duygu, düşünce ve bilgilerin yazılı bir şekilde ifade edilmesi olarak tanımlanan yazma bireyin hayatı boyunca kullanacağı önemli bir beceridir. Bu nedenle yazma her zaman eğitimcilerin ve araştırmacıların ilgi odağı olmuş, bu becerinin kazanımı ve geliştirilmesiyle ilgili kuramsal ve uygulama temelli çok sayıda araştırma yapılmıştır. Bu araştırmaların sınıflara nasıl yansıdığı ise merak konusudur. Bu araştırmada öğretmen adaylarının perspektifinden sınıfta gerçekleştirilen yazma çalışmalarının betimlenmesi amaçlanmıştır. Araştırma nitel yaklaşımla gerçekleştirilmiş olup veriler yapılandırılmış katılımlı olmayan gözlemler ve katılımcılarla yapılan odak grup görüşmeler yoluyla elde edilmiştir. Sınıf öğretmenliği eğitimi son sınıf öğrencileri ve bu öğrencilerin staja gittikleri okullardaki öğretmenler araştırmanın çalışma grubunu oluşturmaktadır. Araştırmada gözlem ve görüşmelerden elde edilen veriler betimsel analizle çözümlenmiştir. Araştırmadan çıkarılan en genel sonuç ilkokul sınıflarında yazmanın geliştirilmesine yönelik uygulamaların yetersiz olduğu yönündedir. Sınıf düzeyinin değişmesine rağmen yazma öncesinde, yazma sırasında ve yazma sonrasında sınıflarda yapılan çalışmalar farklılaşmamaktadır. Araştırmada elde edilen sonuçlar doğrultusunda uygulamaya yönelik öneriler geliştirilmiştir.
The mediating role of basic psychological needs in the relationship between self-determination and meaning in life in adolescent<p>Ergenlerde öz-belirleyicilik ve yaşamda anlam ilişkisinde temel psikolojik gereksinimlerin aracı rolü
Authors: Demirbaş Çelik Nur , Tezcan Fatoş 
Published: May 2017

As in every part of life, concept of meaning in life has an important place during adolescence as a determinant of well-being. In this research concepts of meaning in life of high school students have been investigated with the perception of self-determination, which is a motivation theory. The aim of the study was to test structural equation model in which the relationship between self-determination and meaning in life is mediated by basic psychological need satisfaction. The sample of the study consisteds of 348 High School Student in İstanbul. In order to gather data, Basic Psychological Need Satisfaction Scale (BPNS), Self-Determination Scale (SDS) and the Meaning in Life Questionnaire (MLQ) were used. The data were analysed by using SPSS 20 and LISREL 8.8. The results revealed that satisfaction of basic psychological needs fully mediated the relationship self-determination between and meaning in life in high school students. However, results also showed significant negative relationship between self-determination and search of meaning in life. The results and limitations of the study were discussed and recommendations have been provided to the researchers.Extended English abstract is in the end of PDF (TURKISH) file. ÖzetYaşamda anlam anlayışı, yaşamın her döneminde olduğu gibi iyi oluşun bir belirleyicisi olarak ergenlik döneminde de önemli bir noktada yer almaktadır. Bu araştırma lise öğrencilerinin yaşamda anlam anlayışlarını bir motivasyon kuramı olan öz- belirleme bakış açısıyla incelemektedir. Bu araştırmanın amacı, öz belirleyicilik ile yaşamda anlam arasındaki ilişkide temel psikolojik gereksinimlerin aracı rolünün yapısal eşitlik modeli ile test edilmesidir. Araştırmanın çalışma grubu, İstanbul’da lise öğrenimi gören 348 öğrenciden oluşmaktadır. Araştırmada veri toplamak amacıyla Temel Psikolojik İhtiyaçlar Ölçeği (TPİÖ), Özerk Benlik Yönetimi Ölçeği (ÖBYÖ) ve Yaşamda Anlam Ölçeği (YAÖ) kullanılmıştır. Veriler SPSS ve LISREL 8.8 programı kullanılarak test edilmiştir. Araştırma sonucunda, lise öğrencilerinde öz-belirleme ile yaşamda anlam arasındaki ilişkinin temel psikolojik ihtiyaçların doyumu aracılığıyla sağlandığı bulunmuştur. Bununla birlikte araştırma sonuçları, öz- belirleme ve yaşamda anlam arayışı arasında doğrudan negatif yönde anlamlı bir ilişki olduğunu göstermiştir. Araştırma bulguları ve sınırlılıkları tartışılmış bu bağlamda araştırmacılara yönelik öneriler sunulmuştur.
„Lesson study“ v českých podmínkách: Jak učitelé vnímali svou účast a jaký vliv měla na jejich všímání si didakticko-matematických jevů
Authors: Vondrová Naďa , Cachová Jana , Coufalová Jana , Krátká Magdalena 
Published: May 2017

Abstrakt: Cílem článku je uvést do českého prostoru tzv. lesson study jako specifickou formu dalšího vzdělávání učitelů založenou na spolupráci učitelů při zkvalitňování výuky prostřednictvím plánování, realizace a vyhodnocení experimentální hodiny. Lesson study má společné rysy s akčním výzkumem a souvisí s pojmy kvalifikovaná reflexe a rozvíjející hospitace. Kromě popisu konkrétní realizace lesson study se článek zaměřuje na otázku, jaký vliv měla na zúčastněné učitele (n = 13) z hlediska jejich subjektivního vnímání i z hlediska všímání si didakticko-matematických jevů. Data zahrnují písemné odpovědi na reflektivní úkoly a záznamy diskusí. Data byla analyzována technikami založenými na zakotvené teorii i s použitím existujícího kategoriálního systému. Učitelé považovali práci v lesson study za smysluplnou a subjektivně vnímali, že došlo k posunu jejich schopnosti reflektovat výuku matematiky. Analýza reflektivních úkolů posun ve všímání si didakticko-matematických jevů neukázala. Byly zjištěny rozdíly v hloubce individuální a společné reflexe výukové situace. Závěrem jsou uvedeny předpoklady a bariéry rozšíření lesson study u nás. Klíčová slova: Lesson study, kvalifikovaná reflexe, rozvíjející hospitace, další vzdělávání učitelů
Videokluby jako forma profesního vzdělávání učitelů: otevřenost komunikace z pohledu učitelů
Authors: Minaříková Eva , Uličná Klára , Píšová Michaela , Janík Tomáš , Janík Miroslav 
Published: May 2017

Abstrakt: Tato studie se zabývá videokluby jakožto intenzivní formou profesního vzdělávání učitelů. V teoretické části se zaměřuje na profesní učící se komunity a na využití videosekvencí v rámci profesního rozvoje učitelů. Poté je představeno naše pojetí videoklubů pro učitele anglického jazyka na základních školách. Cílem předkládané studie bylo prozkoumat, jak účastníci videoklubů popisují svou zkušenost s touto formou profesního rozvoje, především vzhledem ke komunikaci a skupinové dynamice. Videoklubů se zúčastnilo 11 učitelů anglického jazyka, kteří pracovali ve třech skupinách. Zdrojem dat byly rozhovory s jednotlivými účastníky, přepisy videozáznamů posledního setkání videoklubů a emailové zpětné vazby účastníků, které psali po každém ze setkání. Data byla zpracována metodou tematické analýzy. Výsledky naznačují, že ačkoliv učitelé popisovali atmosféru videoklubů jako příjemnou a otevřenou, zjevně pociťovali nedostatek kritiky a přítomnost diplomacie a korektnosti. Jejich postoje ke kritice se ale lišily – některým chyběla, jiní ji naopak nevnímali jako nutnou součást videoklubů, jelikož každý z učitelů má vlastní přístup a kritizovat je proto nežádoucí. Tyto postoje otevírají otázku, zda se v některých skupinách nejednalo spíše o pseudokomunitu a vyhýbání se konfliktu a jak tomuto nastavení mohou tvůrci a facilitátoři podobných programů předejít. Klíčová slova: videokluby, profesní rozvoj učitelů, profesní učící se komunita, video v učitelském vzdělávání