bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment and simulation of eco-environmental quality changes in rapid rural urbanization: Xiong’an New Area, China
Authors: Lin Zhongli , Xu Hanqiu , Yao Xiong , Zhu Zhipeng 
Published: October 2024

AbstractXiong’an New Area was established as a state-level new area in 2017 and serves as a typical representative area for studying the ecological evolution of rural areas under rapid urbanization in China. Remote sensing-based ecological index (RSEI) is a regional eco-environmental quality (EEQ) assessment index. Many studies have employed RSEI to achieve rapid, objective, and effective quantitative assessment of the spatio-temporal changes of regional EEQ. However, research that combines RSEI with machine learning algorithms to conduct multi-scenario simulation of EEQ is still relatively scarce. Therefore, this study assessed and simulated EEQ changes in Xiong’an and revealed that: (1) The large-scale construction has led to an overall decline in EEQ, with the RSEI decreasing from 0.648 in 2014 to 0.599 in 2021. (2) Through the multi-scenario simulation, the non-unidirectional evolution of RSEI during the process of urban-rural construction has been revealed, specifically characterized by a significant decline followed by a slight recovery. (3) The marginal effects of urban-rural construction features for simulated RSEI demonstrate an inverted “U-shaped” curve in the relationship between urbanization and EEQ. This indicates that urbanization and EEQ may not be absolute zero-sum. These findings can provide scientific insights for maintaining and improving the regional EEQ in urban-rural construction.
A scalable convolutional neural network approach to fluid flow prediction in complex environments
Authors: Rana Pratip , Weigand Timothy M. , Pilkiewicz Kevin R. , Mayo Michael L. 
Published: October 2024

AbstractWe evaluate the capability of convolutional neural networks (CNNs) to predict a velocity field as it relates to fluid flow around various arrangements of obstacles within a two-dimensional, rectangular channel. We base our network architecture on a gated residual U-Net template and train it on velocity fields generated from computational fluid dynamics (CFD) simulations. We then assess the extent to which our model can accurately and efficiently predict steady flows in terms of velocity fields associated with inlet speeds and obstacle configurations not included in our training set. Real-world applications often require fluid-flow predictions in larger and more complex domains that contain more obstacles than used in model training. To address this problem, we propose a method that decomposes a domain into subdomains for which our model can individually and accurately predict the fluid flow, after which we apply smoothness and continuity constraints to reconstruct velocity fields across the whole of the original domain. This piecewise, semicontinuous approach is computationally more efficient than the alternative, which involves generation of CFD datasets required to retrain the model on larger and more spatially complex domains. We introduce a local orientational vector field entropy (LOVE) metric, which quantifies a decorrelation scale for velocity fields in geometric domains with one or more obstacles, and use it to devise a strategy for decomposing complex domains into weakly interacting subsets suitable for application of our modeling approach. We end with an assessment of error propagation across modeled domains of increasing size.
Comparison of human pluripotent stem cell differentiation protocols to generate neuroblastoma tumors
Authors: Cheng Bo , Fang Wanqi , Pastor Steven , March Alexander R. , Porras Tania , Wu Hong-Wei , Velez Miriam , Parekh Chintan , Maris John M. , Asgharzadeh Shahab , Huang Miller 
Published: October 2024

AbstractNeuroblastoma is the most common pediatric extracranial solid tumor and is derived from trunk neural crest cells (tNCC) and its progenitor sympathoadrenal (SA) cells. While human pluripotent stem cell (PSC) models of neuroblastoma have been described, the PSC were differentiated using protocols that made neural crest cells, but not specifically the trunk subtype. Here, we compared four recent protocols to differentiate pluripotent stem cells (PSC) toward SA cells and examined their efficiency at generating SA cells along with earlier cell states (neuromesodermal progenitors [NMP], tNCC), as well as generating MYCN-driven tumors. Interestingly, the protocols that created cells with the highest level of NMP markers did not produce cells with the highest tNCC or SA cell markers. We identified a protocol that consistently produced cells with the highest level of SA markers using two PSC lines of different genders. This protocol also generated tumors with the highest level of PHOX2B, a marker of neuroblastoma. Transcriptionally, however, each protocol generates tumors that resemble neuroblastoma. Two of the protocols repeatedly produced adrenergic neuroblastoma whereas the other two protocols were ambiguous. Thus, we identified a protocol that reliably generates adrenergic neuroblastoma.
Curviness is a better predictor of a woman’s body attractiveness than the waist-to-hip ratio
Authors: Hübner Ronald , Ufken Emily Sophie 
Published: October 2024

AbstractThe waist-to-hip ratio (WHR) is commonly used as an indicator of mid-body fat distribution and is often used to answer health-related questions. It has also been suggested that a woman’s WHR can signal her reproductive fitness. This notion is supported by evidence indicating a relation between WHR and a woman’s physical attractiveness. However, it was also acknowledged that the actual fitness cue is the curviness of a woman’s body. While curviness is easy to perceive, it is difficult to quantify. Therefore, the WHR is often considered as a simple measure of body curviness. However, the WHR and curviness are not uniquely related. After replicating results of a pioneering study in this area, we therefore tested whether the WHR or curviness better predicts a woman’s physical attractiveness. As stimuli, we used simple line drawings of women’s bodies, differing in their curviness and width. The results demonstrate that curviness is a better predictor, even though we used a relatively simple curvature-based measure of curviness. This outcome indicates that the WHR is a poor measure of a woman’s body curviness and underscores the need for a more accurate measure of curviness when assessing the physical attractiveness of a woman’s body.
Deep-learning based discrimination of pathologic complete response using MRI in HER2-positive and triple-negative breast cancer
Authors: Kim Soo-Yeon , Lee Jinsu , Cho Nariya , Kim Young-Gon 
Published: October 2024

AbstractDistinguishing between pathologic complete response and residual cancer after neoadjuvant chemotherapy (NAC) is crucial for treatment decisions, but the current imaging methods face challenges. To address this, we developed deep-learning models using post-NAC dynamic contrast-enhanced MRI and clinical data. A total of 852 women with human epidermal growth factor receptor 2 (HER2)-positive or triple-negative breast cancer were randomly divided into a training set (n = 724) and a validation set (n = 128). A 3D convolutional neural network model was trained on the training set and validated independently. The main models were developed using cropped MRI images, but models using uncropped whole images were also explored. The delayed-phase model demonstrated superior performance compared to the early-phase model (area under the receiver operating characteristic curve [AUC] = 0.74 vs. 0.69, P = 0.013) and the combined model integrating multiple dynamic phases and clinical data (AUC = 0.74 vs. 0.70, P = 0.022). Deep-learning models using uncropped whole images exhibited inferior performance, with AUCs ranging from 0.45 to 0.54. Further refinement and external validation are necessary for enhanced accuracy.
Impact of photobiomodulation therapy on pro-inflammation functionality of human peripheral blood mononuclear cells – a preliminary study
Authors: Pasternak-Mnich Kamila , Kujawa Jolanta , Agier Justyna , Kozłowska Elżbieta 
Published: October 2024

AbstractResearch into the efficacy of photobiomodulation therapy (PBMT) in reducing inflammation has been ongoing for years, but standards for irradiation methodology still need to be developed. This study aimed to test whether PBMT stimulates in vitro human peripheral blood mononuclear cells (PBMCs) to synthesize pro-inflammatory cytokines, including chemokines. PBMCs were irradiated with laser radiation at two wavelengths simultaneously (λ = 808 nm in continuous emission and λ = 905 nm in pulsed emission). The laser radiation energy was dosed in one dose as a whole (5 J, 15 J, 20 J) or in a fractionated way (5 J + 15 J and 15 J + 5 J) with a frequency of 500, 1,500 and 2,000 Hz. The surface power densities were 177, 214 and 230 mW/cm2, respectively. A pro-inflammatory effect was observed at both the transcript and protein levels for IL-1β after PBMT at the energy doses 5 J and 20 J (ƒ=500 Hz) and only at the transcript level after application of PBMT at energy doses of 20 J (ƒ= 1,500; ƒ=2,000 Hz) and 5 + 15 J (ƒ=500 Hz). An increase in CCL2 and CCL3 mRNA expression was observed after PBMT at 5 + 15 J (ƒ=1,500 Hz) and 15 + 5 J (ƒ=2,000 Hz) and CCL3 concentration after application of an energy dose of 15 J (frequency of 500 Hz). Even though PBMT can induce mRNA synthesis and stimulate PBMCs to produce selected pro-inflammatory cytokines and chemokines, it is necessary to elucidate the impact of the simultaneous emission of two wavelengths on the inflammatory response mechanisms.
Parasagittal dural volume correlates with cerebrospinal fluid volume and developmental delay in children with autism spectrum disorder
Authors: Agarwal Nivedita , Frigerio Giulia , Rizzato Gloria , Ciceri Tommaso , Mani Elisa , Lanteri Fabiola , Molteni Massimo , Carare Roxana O. , Losa Letizia , Peruzzo Denis 
Published: October 2024

Abstract
Background
The parasagittal dura, a tissue that lines the walls of the superior sagittal sinus, acts as an active site for immune-surveillance, promotes the reabsorption of cerebrospinal fluid, and facilitates the removal of metabolic waste products from the brain. Cerebrospinal fluid is important for the distribution of growth factors that signal immature neurons to proliferate and migrate. Autism spectrum disorder is characterized by altered cerebrospinal fluid dynamics.

Methods
In this retrospective study, we investigated potential correlations between parasagittal dura volume, brain structure volumes, and clinical severity scales in young children with autism spectrum disorder. We employed a semi-supervised two step pipeline to extract parasagittal dura volume from 3D-T2 Fluid Attenuated Inversion Recovery sequences, based on U-Net followed by manual refinement of the extracted parasagittal dura masks.

Results
Here we show that the parasagittal dura volume does not change with age but is significantly correlated with cerebrospinal fluid (p-value = 0.002), extra-axial cerebrospinal fluid volume (p-value = 0.0003) and severity of developmental delay (p-value = 0.024).

Conclusions
These findings suggest that autism spectrum disorder children with severe developmental delay may have a maldeveloped parasagittal dura that potentially perturbs cerebrospinal fluid dynamics.
Effect of the polyphenol flavonoids fisetin and quercetin on the adipogenic differentiation of human mesenchymal stromal cells
Authors: Lorthongpanich Chanchao , Charoenwongpaiboon Thanapon , Septham Praphasri , Laowtammathron Chuti , Srisook Pimonwan , Kheolamai Pakpoom , Manochantr Sirikul , Issaragrisil Surapol 
Published: October 2024

Abstract
Fisetin and quercetin, polyphenol flavonoids, have been shown to have a wide range of beneficial pharmacological effects including anti-inflammatory, antioxidative, and anti-cancer. Our previous work shows that fisetin also affects the specification of the adipogenic-osteogenic lineage of human mesenchymal stem cells (hMSCs) by modulating the Hippo-YAP signaling pathway. Although quercetin has a structure similar to that of fisetin, its effects on the functional properties of hMSCs have not yet been investigated. The objective of the present study is to determine the effects of quercetin on the various properties of hMSCs, including proliferation, migration, and differentiation capacity toward adipogenic and osteogenic lineages. The results show that while fisetin increases hMSC adipogenic differentiation, quercetin inhibited adipogenic differentiation of hMSCs. The inhibition is mediated, at least in part, by the activation of hippo signaling and up-regulation of miR-27b, which inhibits the expression of genes involved in all critical steps of lipid droplet biogenesis, resulting in a decrease in the number of lipid droplets in hMSCs. It is possible that the lack of hydroxylation of the 5 position on the A ring of quercetin could be responsible for its different effect on the adipogenic-osteogenic lineage specification of hMSCs compared with fisetin. Molecular docking and molecular dynamics simulation suggested that fisetin and quercetin possibly bind to serine / threonine protein kinases 4 (STK4/MST1), which is an upstream kinase responsible for LATS phosphorylation. Taken together, our results demonstrate more insight into the mechanism underlying the role of flavonoid fisetin and quercetin in the regulation of adipogenesis.
Design of novel multiband bandpass filters based on coupled symmetric short‐circuit stub multimode resonators
Authors: Luo Jie , Liu Zaiyue , Gao Shanshan 
Published: October 2024

AbstractIn this letter, the working mechanism of suggested bandpass filters with connected symmetric short‐circuit stub multimode resonators is described. Because of the design flexibility, the suggested bandpass filters' centre frequencies may be modified based on the design approach. Meanwhile, the suggested bandpass filters have reduced insertion losses and compact sizes. A prototype is built and tested with six passbands centred at 1.57/2.38/3.55/5.14/5.83/6.78 GHz to confirm the design and analysis. Good agreement between the simulated, and measured results is observed, indicating that the proposed structure can be applied in the field of communication, information, and automation.
Design of bandwidth enhancement circular polarisation microstrip antenna loaded with sunflower‐shaped metasurface
Authors: Shen Xiumei , Zhang Chuanyun , Yin Yingzeng , Zhong Xiangjiang 
Published: October 2024

AbstractA circular polarised (CP) microstrip antenna loaded with sunflower‐shaped metasurface (SSM) to enhance the bandwidth using characteristic mode analysis is proposed in this communication. The SSM, divided into inner and outer parts by a ring, consists of equally spaced sectors of equal angles. In this design, the coupled corner‐truncated microstrip antenna with a slot in the centre is employed to obtain CP radiation by exciting two orthogonal modes, which have a 90° phase difference. Meanwhile, it demonstrates that the SSM structure significantly expands the operational bandwidth and exhibits a stable radiation pattern at high frequencies. Simulation and measurement results confirm that this SSM antenna achieves a wide operating bandwidth of 64.3% (4.5–8.76 GHz) and a 3‐dB axial ratio bandwidth of 30.6% (4.7–6.4 GHz), while maintaining a compact profile of 0.68 × 0.68 × 0 0.08 λ03.
Random matrix extended target tracking for trajectory‐aligned and drifting targets
Authors: Şahin Kurtuluş Kerem , Balcı Ali Emre , Özkan Emre 
Published: October 2024

AbstractIn this paper, we propose two random matrix based extended target tracking models, which apply to the trajectory‐aligned and drifting target motions. The trajectory‐aligned model is specifically designed to handle targets moving along the direction of their extent orientations, while the drift model is tailored to targets whose trajectories deviate from their orientations in time. We utilise the well‐known variational Bayes method to perform inference and obtain posterior densities via computationally efficient, analytical, iterative steps. Through comprehensive experiments conducted on simulated and real data, our methods have demonstrated superior performance compared to previous approaches in scenarios involving both drifting and trajectory‐aligned targets. These results highlight the efficacy of our proposed models in accurately tracking targets and estimating their extent.
Dialectiques de l’acte et des séparations auprès des adolescents placés
Authors: Baidi Christophe 
Published: October 2024

L’article a pour objet le nouage entre le passage à l’acte, traité comme une manière réelle pour le sujet de survivre symboliquement à une possibilité d’évanouissement à l’occasion d’une trop grande proximité avec l’objet a cause du désir, ainsi que la séparation, réelle et symbolique, opérée par un éloignement familial. Nous nous soutiendrons d’une pratique clinique auprès d’adolescents dits « sous main de justice », et placés au sein d’un foyer de la Protection Judiciaire de la Jeunesse à la suite de la réalisation de délits. Après une reprise historique et conceptuelle des mécanismes adolescents comme échos de l’infantile, entre passages à l’acte et actings, nous questionnerons les effets cliniques d’une lecture des actes posés en tant que symptômes, paroles récusées mais adressées à un Autre qu’il reste à constituer afin d’opérer une fonction symbolique et soignante.
D’un intérêt à une nécessité de la psychanalyse en milieu pénitentiaire
Authors: Limousin Jordan 
Published: October 2024

Cet article vise à resituer les intérêts de la clinique psychanalytique dans un service de psychiatrie en milieu carcéral, à l’endroit même où le sujet se trouve enfermé et bâillonné jusque dans sa parole. En faisant un retour sur les possibilités du discours analytique de s’insérer dans la psychiatrie de service public, puisqu’il s’agit là du seul lieu où la psychanalyse peut trouver une place dans le milieu carcéral, nous tentons modestement de montrer comment l’analyse se situe à contrecourant du discours du pouvoir établi par Michel Foucault dans « Surveiller et Punir ».
En passant par les nouvelles extensions du panoptisme, nous montrons que la parole du détenu perd de plus en plus sa substance face à une machine judiciaire et carcérale. Alors, par son éthique telle que Lacan la décrit, il est possible pour la psychanalyse de redonner cette importance et cette responsabilité subjective (a contrario de la responsabilité judiciaire) qui permet au sujet de donner un sens à ses actes et donc par là-même de s’ouvrir à une nouvelle forme de discours, qui, de surcroît, lui permettra de symboliser quelque chose du réel qui l’a dépassé et mis à cette place.
Une jeunesse sans à venir : confrontation à la clinique du vide
Authors: Cloës Claude , Marche Jean-Christophe 
Published: October 2024

La clinique psychiatrique contemporaine confronte les soignants en psychiatrie à des syndromes et des discours inédits qu’il convient d’interroger afin de pouvoir adapter les propositions thérapeutiques. La modernité produit des effets sur la construction psychique des jeunes qui se traduit en particulier par une clinique de la « douleur du vide » où le sujet semble suspendu dans une temporalité dénuée de toute projection vers l’avenir. L’enjeu des professionnels est de dépasser les effets négatifs du contre-transfert afin de réinscrire ces jeunes dans un à venir, leur offrant de passer de la douleur du vide à la souffrance de l’être.
L’amour sans frontière
Authors: Alerini Paul 
Published: October 2024

Dans le cours de la consultation bénévole d’un migrant africain, le don d’un comprimé d’un anxiolytique a produit un effet thérapeutique immédiat sur ses insomnies, ce qui n’est explicable que par l’effet d’un transfert qui noue une pratique psychanalytique à l’analogie d’une pratique traditionnelle. L’histoire clinique de ce patient est liée à celle de sa femme qui était en psychothérapie avec une collègue psychanalyste. C’est l’histoire d’un grand amour qui a survécu aux épreuves de l’exil.
Témoignage sur une expérience hors-cadre de la psychanalyse.
Corps et murs parlants
Authors: Lévy Alexandre 
Published: October 2024

Ce travail présente l’œuvre de l’artiste chinois Liu Bolin, jouant sur la disparition en trompel’œil des corps dans l’environnement urbain. À partir de ces images photographiques révélant les dimensions de la honte ainsi que celle de la hantise, nous pouvons tirer un certain nombre d’enseignements à l’endroit de la clinique des corps parlant pris dans le lien social, notamment le fait que le mur détermine et façonne le corps du parlant ainsi que la manière de se soutenir dans le monde. Notre démarche prend l’œuvre de Liu Bolin comme point de départ afin de dégager des pistes de réflexions cliniques autour des conséquences du réel du mur sur le corps des parlêtres. Il en résulte un développement autour de la « hontologie », science de l’être qui, avec un « h » ne peut en passer que par l’affect de honte, et de la « hantologie », science de la hantise.
Dietary Risk Factors: Fiber and Beyond
Authors: Roberson Jeffrey L. , Pettke Erica N. 
Published: October 2024

AbstractThe incidence of diverticulosis continues to rise throughout western nations with collateral increases in the frequency of diverticulitis. However, the mechanism behind the transition from asymptomatic diverticulosis to complicated diverticulitis is incompletely understood. Dietary intake has long been investigated as one of, if not the main, links in the continuum of disease. As the world's diet continues to evolve with increasingly prevalent processed and high-fat food, longitudinal studies have emerged with a goal of finally explaining how diet influences the development of diverticulitis. While low-fiber, high-fat diets are believed to play a role in the development of an index episode of diverticulitis, the role in recurrent disease remains uncertain. More recent avenues of interest include the role of the microbiome, probiotics, and adjunct treatments such as 5-ASA and rifaximin. While robust longitudinal studies have identified an association between low-fiber, high-fat diets and the development of index diverticulitis, the impact of dietary composition and modification on disease recurrence remains unclear and fails to meet the threshold for societal recommendations.
Multi-mode interference waveguide chip-scale spectrometer (invited)
Authors: Amin Md Nafiz , Ganjalizadeh Vahid , Adams Tyler J. , Dixon Porter B. , Weber Zoe , DeMartino Matthew , Bundy Kevin , Hawkins Aaron R. , Schmidt Holger 
Published: October 2024

Spectral analysis of light is one of the oldest and most versatile scientific methods and the basis of countless techniques and instruments. Miniaturized spectrometers have recently seen great advances, but challenges remain before they are widely deployed. We report an integrated photonic spectrometer that achieves high performance with minimal component complexity by combining imaging of light propagation patterns in multi-mode interference waveguides with machine learning analysis. We demonstrate broadband operation in the visible and near-infrared, 0.05 nm spectral resolution, and an array of four spectrometers on a single chip. Two canonical applications are implemented: spectral analysis of the solar spectrum with neural network reconstruction and detection of Rayleigh scattering from microbeads on an optofluidic chip using principal component classification. These results illustrate the potential of this approach for high-performance spectroscopy across disciplines.