bluuebunny/crossref_metadata_2025_split huggingface dataset:
ENSO-conditioned weather resampling method for seasonal ensemble streamflow prediction
Authors: Beckers Joost V. L. , Weerts Albrecht H. , Tijdeman Erik , Welles Edwin 
Published: August 2016

Abstract. Oceanic–atmospheric climate modes, such as El Niño–Southern Oscillation (ENSO), are known to affect the local streamflow regime in many rivers around the world. A new method is proposed to incorporate climate mode information into the well-known ensemble streamflow prediction (ESP) method for seasonal forecasting. The ESP is conditioned on an ENSO index in two steps. First, a number of original historical ESP traces are selected based on similarity between the index value in the historical year and the index value at the time of forecast. In the second step, additional ensemble traces are generated by a stochastic ENSO-conditioned weather resampler. These resampled traces compensate for the reduction of ensemble size in the first step and prevent degradation of skill at forecasting stations that are less affected by ENSO. The skill of the ENSO-conditioned ESP is evaluated over 50 years of seasonal hindcasts of streamflows at three test stations in the Columbia River basin in the US Pacific Northwest. An improvement in forecast skill of 5 to 10 % is found for two test stations. The streamflows at the third station are less affected by ENSO and no change in forecast skill is found here.
A Bayesian consistent dual ensemble Kalman filter for state-parameter estimation in subsurface hydrology
Authors: Ait-El-Fquih Boujemaa , El Gharamti Mohamad , Hoteit Ibrahim 
Published: August 2016

Abstract. Ensemble Kalman filtering (EnKF) is an efficient approach to addressing uncertainties in subsurface groundwater models. The EnKF sequentially integrates field data into simulation models to obtain a better characterization of the model's state and parameters. These are generally estimated following joint and dual filtering strategies, in which, at each assimilation cycle, a forecast step by the model is followed by an update step with incoming observations. The joint EnKF directly updates the augmented state-parameter vector, whereas the dual EnKF empirically employs two separate filters, first estimating the parameters and then estimating the state based on the updated parameters. To develop a Bayesian consistent dual approach and improve the state-parameter estimates and their consistency, we propose in this paper a one-step-ahead (OSA) smoothing formulation of the state-parameter Bayesian filtering problem from which we derive a new dual-type EnKF, the dual EnKFOSA. Compared with the standard dual EnKF, it imposes a new update step to the state, which is shown to enhance the performance of the dual approach with almost no increase in the computational cost. Numerical experiments are conducted with a two-dimensional (2-D) synthetic groundwater aquifer model to investigate the performance and robustness of the proposed dual EnKFOSA, and to evaluate its results against those of the joint and dual EnKFs. The proposed scheme is able to successfully recover both the hydraulic head and the aquifer conductivity, providing further reliable estimates of their uncertainties. Furthermore, it is found to be more robust to different assimilation settings, such as the spatial and temporal distribution of the observations, and the level of noise in the data. Based on our experimental setups, it yields up to 25 % more accurate state and parameter estimations than the joint and dual approaches.
Efficacy and Safety of a Cationic Emulsion in the Treatment of Moderate to Severe Dry Eye Disease: A Randomized Controlled Study
Authors: Robert Pierre-Yves , Cochener Béatrice , Amrane Mourad , Ismail Dahlia , Garrigue Jean-Sébastien , Pisella Pierre-Jean , Baudouin Christophe 
Published: August 2016

Purpose To evaluate the efficacy and safety of a preservative-free cationic emulsion (CE) with a 0.18% hyaluronate sodium (HS) solution in patients with moderate to severe dry eye disease (DED) with keratitis or keratoconjunctivitis. Methods Eighty-five patients were randomized (1:1) in this multicenter, prospective, reference-controlled, parallel-group, investigator-masked study to receive CE (n = 44) or HS (n = 41). Clinical signs and symptoms were assessed over 3 months. The primary efficacy endpoint was noninferiority of CE to HS in change from baseline of ocular surface staining (OSS) score at 1 month. Results In the per protocol (PP) set and full analysis set (FAS), CE showed a similar and noninferior (p<0.0001) improvement in OSS scores compared with HS at 1 month (PP: −2.5 ± 1.3 vs −1.9 ± 1.6; FAS: −2.2 ± 1.5 vs −2.0 ± 1.8 for CE vs HS). Other clinical signs of DED similarly improved in both groups. In the FAS, global symptoms score of ocular discomfort was significantly better with CE compared with HS at 1 month (-14.8 ± 17.3 vs −7.6 ± 14.2; p = 0.0469), including greater alleviation of itching (-14.8 ± 21.2 vs −1.7 ± 19.7; p = 0.0100) and eye dryness (-21.9 ± 28.3 vs −8.4 ± 21.4; p = 0.0016). Similar trends were observed at 3 months for itching and eye dryness. Investigator global efficacy assessment and quality of life scores for eye pain and driving favored CE at 3 months. Incidence of adverse events was low in both treatment groups. Conclusions CE was similar to HS with regards to safety and efficacy for objective signs but was superior to HS in improving DED symptoms in patients with moderate to severe DED.
Understanding the Determinants of Myopic Choroidal Neovascularization and Response to Treatment
Authors: Leveziel Nicolas , Gaucher David , Baillif Stéphanie , Benouaich Xavier , Chartier Claire , Grenet Thyphaine , Gualino Vincent , Krivosic Valérie , Delyfer Marie Noelle 
Published: August 2016

Purpose The pathophysiologic pathways that govern the development of choroidal neovascularization (CNV) are complex. Patchy atrophy and lacquer cracks are known to be major anatomic risk factors for the development of myopic CNV, but they are not alone and much remains to be understood about other factors that influence development. In addition, a greater understanding of the modifiable and nonmodifiable factors that influence outcome, resolution, and recurrence after intravitreal injection of anti-vascular endothelial growth factor (VEGF) could lead to more personalized treatment algorithms that integrate parameters other than the presence of CNV itself and could help improve clinical outcomes and reduce recurrence. Methods We reviewed recently published data on risk factors for CNV and predictors of response to anti-VEGF treatments. In particular, data pertaining to age, sex, genetic predisposition, baseline visual acuity, axial length, staphyloma, lacquer cracks, atrophic lesions, choroidal thickness or choroidal thinning, characteristics of CNV such as duration, localization, and size of CNV, and treatment considerations such as choice of treatment, loading doses, and combination treatments were reviewed. Results Our analysis showed that the body of evidence is incomplete. Conclusions Additional studies are required to identify high-risk patients and to develop personalized therapeutic approaches.
Periprosthetic Femoral Bone Loss in Total Hip Arthroplasty: Systematic Analysis of the Effect of Stem Design
Authors: Knutsen Ashleen R. , Lau Nicole , Longjohn Donald B. , Ebramzadeh Edward , Sangiorgio Sophia N. 
Published: August 2016

Introduction Periprosthetic bone loss may lead to major complications in total hip arthroplasty (THA), including loosening, migration, and even fracture. This study analysed the influence of femoral implant designs on periprosthetic bone mineral density (BMD) after THA. Methods The results of all previous published studies reporting periprosthetic femoral BMD following THA were compiled. Using these results, we compared percent changes in bone loss as a function of: femoral stem fixation, material, and geometry. Results The greatest bone loss was in the calcar region (Gruen Zone 7). Overall, cemented stems had more bone loss distally than noncemented stems, while noncemented stems had more proximal bone loss than cemented stems. Within noncemented stems, cobalt-chromium (CoCr) stems had nearly double the proximal bone loss compared to titanium (Ti) alloy stems. Finally, within noncemented titanium alloy group, straight stems had less bone loss than anatomical, tapered, and press-fit designs. Discussion The findings from the present study quantified percent changes in periprosthetic BMD as a function of fixation method, alloy, and stem design. While no one stem type was identified as ideal, we now have a clearer understanding of the influence of stem design on load transfer to the surrounding bone.
Enhanced Proliferation and Differentiation Effects of a CGRP- and Sr-Enriched Calcium Phosphate Cement on Bone Mesenchymal Stem Cells
Authors: Liang Wei , Li Li , Cui Xu , Tang Zhongfei , Wei Xiaomou , Pan Haobo , Li Bing 
Published: August 2016

Introduction Because of its good osteoconductivity, strontium (Sr) ranelate has been extensively used as a bone substitute for the treatment of bone disorders. To facilitate treatment, Sr is also incorporated into calcium phosphate cement (Sr-CPC); however, the Sr from Sr-CPC is not sufficient to induce a significant increase of bone mass in an ovariectomized rat model. To improve the efficiency of Sr-CPC, we developed a calcitonin gene–related peptide (CGRP)- and Sr-enriched CPC (CGRP-Sr-CPC). Methods We used X-ray diffraction and Fourier transform infrared spectroscopy to measure properties of CGRP-Sr-CPC. We also employed a cell proliferation assay, alkaline phosphatase (ALP) assay and real-time PCR to assess the effects of CPC implants on proliferation and differentiation of bone mesenchymal stem cells (BMSCs) from an ovariectomized rat model. Results CGRP did not change the composition, pore sizes and compressive strength of the cement body as compared with Sr-CPC. Meanwhile, CGRP-Sr-CPC did not show cell cytotoxicity to BMSCs. Further, CGRP and Sr released from CGRP-Sr-CPC significantly enhanced the cell proliferation of BMSCs and increased the activity of ALP during differentiation of BMSCs, compared with CGRP- or Sr-CPC. Moreover, CGRP-Sr-CPC significantly up-regulated the expression levels of osteogenic differentiation-related genes including Alp, Bmp2, Osteonectin and Runx2 during differentiation. Conclusions These findings demonstrate the optimized effects of CGRP- and Sr-enriched CPC in promoting proliferation and osteogenic differentiation of BMSCs, suggesting the potential ability of this novel cement to assist the formation of new bone during osteoporosis-induced bone disorders.
Prognostic Significance of CD24 and CD44 in Breast Cancer: A Meta-Analysis
Authors: Wang Zhu , Wang Qianqian , Wang Qi , Wang Yanping , Chen Jie 
Published: August 2016

Objective Numerous studies have focused on the prognostic roles of CD24 and CD44 in breast cancer, but the results have been equivocal. The aim of this study was to gain better insight into the relationship between expression of CD24 and of CD44, either alone or in combination, and prognostic parameters in breast cancer. Methods Publications addressing the associations of CD24 or CD44 expression with survival outcome in breast cancer were selected for the meta-analysis according to defined criteria. Studies were pooled and odds ratios (ORs) or hazard ratios (HRs) were calculated. Publication bias and sensitivity analyses were also conducted. Results Sixteen studies comprising 5,697 breast cancer cases were included in our meta-analysis. Overall, CD24 overexpression was significantly associated with histological grade (OR = 1.52; 95% CI 1.12-2.06, p = 0.007), stage (OR = 1.74; 95% CI 1.27-2.40, p<0.001), shortened overall survival (HR = 1.48; 95% CI 1.21-1.80, p<0.001) and disease-free survival (HR 1.45, 95% CI 1.19-1.76, p<0.001), while no such association was observed when we limited our analysis to CD44 and CD44+/CD24- phenotypes. Subgroup analyses for CD24 according to the studies categorized by ethnicity, staining patterns and follow-up period were also conducted, and supported the stability of the prognostic role of CD24. Conclusions Our study demonstrated that the putative stem cell marker CD24 was significantly associated with worse survival based on the obtained data. In particular, CD24 may play a role in tumorigenesis and cancer progression. However, further large-scale studies are needed to confirm these findings.
Malignant Transformation of Endometriosis: An Unusual Diverticular Mass
Authors: Mohling Shanti I. , Elkattah Rayan , Eliason Rachel , Boren Todd P. 
Published: August 2016

Background Malignant transformation of endometriosis may occur years following hysterectomy and oophorectomy. It may present with a pelvic mass, pain or vaginal bleeding. Risk factors have been poorly defined, but may include exogenous or endogenous unopposed estrogens. Case This report presents a case of malignant transformation of endometriosis resulting in endometrioid adenocarcinoma of a colonic diverticulum in a patient on unopposed estrogen. Conclusions Patients with a history of endometriosis who present with a pelvic mass should be evaluated for the possibility of a tumor arising from the endometriosis, even long after definitive surgical treatment. Sampson's criteria for malignant transformation of endometriosis remain relevant. The continued practice of prescribing unopposed estrogen after hysterectomy to patients with a history of endometriosis may contribute to the frequency of this otherwise uncommon disease.
Congress Report from 2nd Society of Endometriosis and Uterine Disorders Congress, 12-14 May 2016, Barcelona, Spain
Authors: González-Foruria Iñaki , Gracia Meritxell , Martínez Maria José , Carmona Francisco 
Published: August 2016

Adenomyosis was the main topic in the 2016 Society of Endometriosis and Uterine Disorders (SEUD) Congress. Latest evidence in endometriosis and other uterine disorders, such as fibroids and abnormal uterine bleeding (AUB) were also covered. About 106 oral communications, practical sessions, and debates on etiology, pathogenesis, diagnosis and treatment of the different themes were presented. Posters on the same topics were on view. Live surgical sessions and video sessions were also held. Six “tips and tricks” sessions in endometriosis and uterine disorders were scheduled at the beginning of each day throughout the congress. Monographic own-language sessions comprising Canadian, Spanish, Asian, Russian and Latin American participants were held with presenters contributing their own vision of the congress topics. Finally, the congress ended with a patient session: dedicated to those who are affected by endometriosis: pain, quality of life, sex-life, and environment were issues covered by specialists and the testimonies of the patients also had their place in the congress.
Predictors of Radio-cephalic Arteriovenous Fistulae Patency in an Asian Population
Authors: Lo Zhiwen Joseph , Tay Wee Ming , Lee Qinyi , Chua Jia Long , Leong Tan Glenn Wei , Chandrasekar Sadhana , Narayanan Sriram 
Published: August 2016

Purpose To identify predictors of arteriovenous fistula (AVF) patency in Asian patients with autogenous radio-cephalic arteriovenous fistula (RCAVF). Methods Retrospective review of 436 RCAVFs created between 2009 and 2013. Predictors of patency were identified with univariate and multivariate analysis. Kaplan-Meier survival analysis and log-rank test were used to calculate patency rates. Results Overall secondary patency rate was 72% at 12 months, 69% at 24 months, 58% at 36 months, 57% at 48 months, 56% at 60 months and 54% at 72 months. Univariate analysis showed that factors which predict for patency include male gender (p = 0.003), good diabetic control (p = 0.025), aspirin use (p = 0.031), pre-dialysis status (p = 0.037), radial artery diameter (p = 0.029) and non-calcified radial arteries (p = 0.002). Age (p = 0.866), cephalic vein diameter (p = 0.630) and surgeon grade (p = 0.472) did not predict for primary AVF failure. Multivariate analysis revealed the male gender to be an independent predictor for patency (odds ratio 1.99, p = 0.01). Subset analysis showed a significantly larger average radial artery diameter of 2.3 mm amongst males, as compared to 1.9 mm amongst females (p = 0.001) and no statistical difference in the average cephalic vein diameter. Conclusions Within our Asian study population, 12-month patency rate of RCAVF is 72%, 69% at 24 months, 58% at 36 months, 57% at 48 months, 56% at 60 months and 54% at 72 months. Male gender is an independent predictor for RCAVF patency. In females or patients with calcified radial arteries, a more proximal AVF should be considered.
Rationale and Protocol of AIRC IG-13218, Short-Term Radiotherapy for Early Prostate Cancer with Concomitant Boost to the Dominant Lesion
Authors: Timon Giorgia , Ciardo Delia , Bazani Alessia , Garioni Maria , Maestri Davide , De Lorenzo Daniela , Pansini Floriana , Cambria Raffaella , Rondi Elena , Cattani Federica , Marvaso Giulia , Zerini Dario , Vischioni Barbara , Ciocca Mario , Russo Stefania , Molinelli Silvia , Golino Federica , Scroffi Valerio , Rojas Damaris P. , Fodor Cristiana , Petralia Giuseppe , Santoro Luigi , De Cobelli Ottavio , Orecchia Roberto , Jereczek-Fossa Barbara A. 
Published: August 2016

Introduction Of the different treatments for early prostate cancer, hypofractionated external-beam radiotherapy is one of the most interesting and studied options. Methods The main objective of this phase II clinical study is to evaluate the feasibility, in terms of the incidence of acute side effects, of a new ultra-hypofractionated scheme for low- or intermediate-risk prostate cancer patients treated with the latest imaging and radiotherapy technology, allowing dose escalation to the dominant intraprostatic lesion identified by multiparametric magnetic resonance imaging. Secondary endpoints of the study are the evaluation of the long-term tolerability of the treatment in terms of late side effects, quality of life, and efficacy (oncological outcome). Results The study is ongoing, and we expect to complete recruitment by the end of 2016. Conclusions Like in previous studies, we expect ultra-hypofractionated radiation treatment for prostate cancer to be well tolerated and effective. Trial registration ClinicalTrials.gov identifier: NCT01913717.
Robot-Assisted Laparoscopic Pyeloplasty in a Pediatric Patient with Horseshoe Kidney: Surgical Technique and Review of the Literature
Authors: Oderda Marco , Calleris Giorgio , Allasia Marco , Dalmasso Ettore , Falcone Marco , Catti Massimo , Merlini Emilio , Gontero Paolo 
Published: August 2016

Objective The aim of this study was to describe the technical aspects of a robotic pyeloplasty in pediatric patients with uretero-pelvic junction obstruction (UPJO) in horseshoe kidney (HSK) through the report of our recent case, and to outline the state of the art of minimally invasive pyeloplasty (MIP) with a systematic review of the literature. Methods We describe all the steps of our surgery performed on an 11-year-old patient with left UPJO in HSK in detail. All the anatomic landmarks are clearly showed, with particular attention to trocar placement in a pediatric patient. A systematic review of the literature on the outcomes of MIP in HSK patients has been performed, including 16 articles. Results Our surgery was successful following a standardized approach. However, we recorded a rare complication, the herniation of a small portion of omentum through the 8 - mm defect used for the caudal robotic port. The evidence synthesis shows excellent postoperative outcomes for both laparoscopic and robot-assisted laparoscopic pyeloplasties in HSK patients. Probably, MIP should be preferred to the traditional open approach in these patients, when feasible. Conclusions Transperitoneal robotic pyeloplasty is an excellent minimally invasive choice for the treatment of UPJO in HSK pediatric patients. The pediatric setting should prompt attention to every detail to avoid unfortunate complications.
Salas de cinema em Londrina: conhecimentos prévios e o uso da “Folha de Londrina” para o estudo do Cine Ouro Verde
Authors: Sussai Matheus Henrique Marques 
Published: August 2016

<p>O presente texto visa apresentar os resultados obtidos nas atividades realizadas por um bolsista do Programa Institucional de Bolsa de Iniciação à Docência (PIBID) de licenciatura em História, pela Universidade Estadual de Londrina, no segundo semestre de 2014. A partir do tema “Londrina: 80 Anos”, foram trabalhados temas como “cinema” e “salas de cinema” na sala de aula. As atividades se basearam em questionários de conhecimentos prévios e em discussões das fontes sobre o Cine Ouro Verde em sala de aula, sendo essas fontes artigos de jornais. A partir das atividades com os alunos, consideramos que temas como o cinema, que estão muito perto da vida dos alunos, os interessam muito, facilitando uma percepção de que fazem parte da História que tanto estudam nos livros didáticos, sendo agentes ativos na construção do seu conhecimento. O relato de experiência docente também é tema deste trabalho, sendo o primeiro contato do aluno de licenciatura em História com a sala de aula importantíssimo para a sua formação profissional. </p><p> </p>
Um silêncio historiográfico: O livro didático regional e as pesquisas acadêmicas
Authors: Ferreira Danielle Da Silva 
Published: August 2016

<p align="center">Esse texto tem por objetivo caracterizar o escopo epistemológico que cerca a concepção de livro didático regional de História, bem como analisar as formas como os objetos culturais “livro didático” e “livro didático regional” aparecem nas pesquisas acadêmicas de 2008 à 2013. Partimos do pressuposto de que esse tipo de pesquisa faz-se ausente do cenário acadêmico, tendo em vista estudos anteriores, como de Caimi (2013), que já anunciavam de carência de investigações sobre publicações didáticas regionais no cenário analítico acadêmico brasileiro. Constatamos, a partir de pesquisa em base de dados online, que as obras didáticas regionais, enquanto espaço de criação simbólica, de produção histórica humana e de registro de narrativa didática/histórica, apresentam-se como um campo frutífero de inquirições, especialmente por confirmarmos sua falta no cenário atual. Registramos a importância desse estudo para que demais pesquisadores atentem para este silêncio historiográfico e que, nessa premissa, o livro didático e o livro didático regional possam se consolidar cada vez mais como objeto de investigação pedagógica e histórica.</p><p> </p><p align="center">Livro didático regional – Anos iniciais – Ensino de História</p><div><br clear="all" /><br /><div><p> </p></div></div>
Herstelbemiddeling voor minderjarigen in Vlaanderen: specifieke rol van de advocaat
Authors: Claeys Mathias 
Published: August 2016

Mediaton for minors in Flanders: the specific role of the lawyer
In Antwerp there is a strong involvement of lawyers in all mediations for minor suspects following. All minor suspects are automatically assigned a lawyer. In this article the author describes the current mediation procedure for minor suspects. Furthermore he gives some personal comments from his perspective as a mediator.
Herstelrecht en de strafrechtadvocaat 2.0
Authors: de Haas Alrik 
Published: August 2016

Restorative Justice and the criminal lawyer 2.0
In the Netherlands more and more criminal lawyers recognize the importance of Restorative Justice. The author illustrates this on the basis of several criminal cases in different phases of the criminal process. Under conditions Restorative Justice is of importance for all parties, including the suspect/offender. Criminal lawyers have to find the courage to overcome cold feet, so that they can fully meet the needs and interests of their clients.