bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane
Authors: Mizuno Akira , Matsui Kouhei , Shuto Satoshi 
Published: June 2017

AbstractPeptidomimetics, non‐natural mimicries of bioactive peptides, comprise an important class of drug molecules. The essence of the peptidomimetic design is to mimic the key conformation assumed by the bioactive peptides upon binding to their targets. Regulation of the conformation of peptidomimetics is important not only to enhance target binding affinity and selectivity, but also to confer cell‐membrane permeability for targeting protein–protein interactions in cells. The rational design of peptidomimetics with suitable three‐dimensional structures is challenging, however, due to the inherent flexibility of peptides and their dynamic conformational changes upon binding to the target biomolecules. In this Minireview, a three‐dimensional structural diversity‐oriented strategy based on the characteristic structural features of cyclopropane to address this challenging issue in peptidomimetic chemistry is described.
Tetrameric and Dimeric [N⋅⋅⋅I+⋅⋅⋅N] Halogen‐Bonded Supramolecular Cages
Authors: Turunen Lotta , Peuronen Anssi , Forsblom Samu , Kalenius Elina , Lahtinen Manu , Rissanen Kari 
Published: June 2017

AbstractTripodal N‐donor ligands are used to form halogen‐bonded assemblies via structurally analogous Ag+‐complexes. Selective formation of discrete tetrameric I6L4 and dimeric I3L2 halonium cages, wherein multiple [N⋅⋅⋅I+⋅⋅⋅N] halogen bonds are used in concert, can be achieved by using sterically rigidified cationic tris(1‐methyl‐1‐azonia‐4‐azabicyclo[2.2.2]octane)‐mesitylene ligand, L1(PF6)3, and flexible ligand 1,3,5‐tris(imidazole‐1‐ylmethyl)‐2,4,6‐trimethylbenzene, L2, respectively. The iodonium cages, I6L14(PF6)18 and I3L22(PF6)3, were obtained through the [N⋅⋅⋅Ag+⋅⋅⋅N]→ [N⋅⋅⋅I+⋅⋅⋅N] cation exchange reaction between the corresponding Ag6L14(PF6)18 and Ag3L22(PF6)3 coordination cages, prepared as intermediates, and I2. The synthesized metallo‐ and halonium cages were studied in solution by NMR, in gas phase by ESI‐MS and in the solid‐state by single crystal X‐ray diffraction.
(PU)2M2: A potentially underperforming‐aware path usage management mechanism for secure MPTCP‐based multipathing services
Authors: Cao Yuanlong , Song Fei , Luo Guoliang , Yi Yugen , Wang Wenle , You Ilsun , Wang Hao 
Published: June 2017

SummaryMultipath TCP (MPTCP) is a promising transport protocol that allows a multihomed device to simultaneously use multiple network interfaces to send application data over multiple paths. However, although applying MPTCP to data delivery introduces many and attractive benefits, the MPTCP is vulnerable to network attacks. When a path within the MPTCP connection suffers from some types of attacks (eg, a denial‐of‐service attack) and becomes underperforming, it will undoubtedly cause transmission interruption in the stable paths and thus degrade the application‐level performance. Unfortunately, the MPTCP path management mechanism is very simple and cannot timely prevent the usage of underperforming paths in multipath transmission. In this paper, we introduce a new “potentially underperforming” (PU) concept to MPTCP and propose a novel PU‐aware path usage management mechanism ((PU)2M2) for MPTCP aiming to (1) detect and declare an underperforming path and prevent the usage of underperforming paths in multipath transmission, (2) provide a finite‐state‐machine model to change per‐path's state accordingly and effectively manage multiple paths for data transmission, and (3) alleviate the packet reordering problem and make MPTCP avoid throughput performance degradation during network underperforming. We demonstrate the benefits of applying (PU)2M2 to MPTCP.
Phenolics, fatty acids, and biological potential of selected Croatian EVOOs
Authors: Kulišić Bilušić Tea , Melliou Elleni , Giacometti Jasminka , Čaušević Amir , Čorbo Selma , Landeka Marija , Magiatis Prokopios 
Published: June 2017

Nutritional value of extra virgin olive oil is associated with its complex chemical composition. The aim of this study was to determine phenolic secoiridoids in Extra virgin olive oils (EVOOs) from autochthonous Croatian cultivars (Drobnica, Krvavica, Lastovka, and Oblica) by qNMR, to determine simple phenolics by UPLC, as well as to analyze the fatty acid profile, the antioxidant activity, and the oxidative stability of selected oils. This is the first study on chemical and biological characterization of selected autochthonous olives varieties. Drobnica EVOO contained the highest amount of total phenols and major secoiridoid derivatives (oleocanthal, oleacein, oleuropein aglycon, and ligstroside aglycon) compared to other oils. The antioxidant activity of Drobnica phenolics was very high by FRAP and copper‐induced LDL oxidation assays, while the oxidative stability of Drobnica oil by Rancimat method was very long (23 h).Practical applications: This study represents the contribution to the research of chemical and biological potential of monovarietal extra virgin olive oil from Croatia. EVOOs from selected Croatian autochthonous cultivars had very high phenolic content that is related to high inhibitory rate of copper‐induced oxidation of human LDL as well as the long oxidative stability. Drobnica EVOO showed very long oxidative stability. EFSA approved health claim on olive oil polyphenols (EU, 432/2012) and selected Croatian cultivars, especially Drobnica, are of interest due to its high phenolic content and strong biological potential.
The effects and toxicity of cathinones from the users' perspectives: A qualitative study
Authors: Assi Sulaf , Gulyamova Nargilya , Kneller Paul , Osselton David 
Published: June 2017

AbstractObjectiveThe objective of this study is to explore the users' perspectives regarding the effects and toxicity of cathinones.MethodsA systematic search of Internet discussion forums yielded 303 threads relevant to the research objectives. The threads were analysed by conventional content analysis where concepts were developed from codes and themes.ResultsThe study identified 3 main themes in relation to cathinone use, effects, and toxicity. The first theme considered the modalities of intake of cathinones in relation to the derivative taken (mainly mephedrone, 3‐methylmethcathinone, and methylenedioxypyrovalerone), route of administration (eyeballing, insufflation, smoking, intravenous, oral, rectal, and sublingual), multidrug use, and purity of the cathinone derivative. The second theme characterised the main effects of cathinones, that is, increased energy, euphoria, and empathogenic. Toxic effects were reported regarding the nervous system (anxiety, hallucinations, nervousness, and paranoia), cardiovascular system (angina, myocardial infarction, and tachycardia), skin (discolouration, itching, and allergy), and renal system (difficulty in urination). Drug–drug interactions were also reported including multiple drug use between cathinones, stimulants, depressants, and hallucinogens.ConclusionsThe Internet discussion forums provide useful sources of information regarding the effects and toxicity of cathinones, which can be taken into account when assessing the safety of drugs.
Inverting suprastomal granulomas
Authors: Schweiger Cláudia , Hart Catherine K. , Cotton Robin T. , Rutter Michael J. 
Published: June 2017

Although suprastomal granulomas are a common complication of tracheotomy, they usually are an incidental finding and do not always require treatment. However, large granulomas may require removal, either to assist with speech production or to make the airway safer in the event of an accidental decannulation.Very large suprastomal granulomas extending up to or even through the vocal cords have been described. However, inverting suprastomal granulomas extending distally down the length of a tracheotomy tube have not been previously described.We present two cases of large suprastomal granulomas that extended distally down the trachea. Both extended beyond the tip of the tracheotomy tube, causing partial airway obstruction, and therefore required excision. Laryngoscope, 127:2883–2885, 2017
Ceftriaxone reduces L‐dopa–induced dyskinesia severity in 6‐hydroxydopamine parkinson's disease model
Authors: Chotibut Tanya , Meadows Samantha , Kasanga Ella A. , McInnis Tamara , Cantu Mark A. , Bishop Christopher , Salvatore Michael F. 
Published: June 2017

ABSTRACTBackground: Increased extracellular glutamate may contribute to l‐dopa induced dyskinesia, a debilitating side effect faced by Parkinson's disease patients 5 to 10 years after l‐dopa treatment. Therapeutic strategies targeting postsynaptic glutamate receptors to mitigate dyskinesia may have limited success because of significant side effects. Increasing glutamate uptake may be another approach to attenuate excess glutamatergic neurotransmission to mitigate dyskinesia severity or prolong the time prior to onset. Initiation of a ceftriaxone regimen at the time of nigrostriatal lesion can attenuate tyrosine hydroxylase loss in conjunction with increased glutamate uptake and glutamate transporter GLT‐1 expression in a rat 6‐hydroxydopamine model. In this article, we examined if a ceftriaxone regimen initiated 1 week after nigrostriatal lesion, but prior to l‐dopa, could reduce l‐dopa–induced dyskinesia in an established dyskinesia model.Methods: Ceftriaxone (200 mg/kg, intraperitoneal, once daily, 7 consecutive days) was initiated 7 days post‐6‐hydroxydopamine lesion (days 7‐13) and continued every other week (days 21‐27, 35‐39) until the end of the study (day 39 postlesion, 20 days of l‐dopa).Results: Ceftriaxone significantly reduced abnormal involuntary movements at 5 time points examined during chronic l‐dopa treatment. Partial recovery of motor impairment from nigrostriatal lesion by l‐dopa was unaffected by ceftriaxone. The ceftriaxone‐treated l‐dopa group had significantly increased striatal GLT‐1 expression and glutamate uptake. Striatal tyrosine hydroxylase loss in this group was not significantly different when compared with the l‐dopa alone group.Conclusions: Initiation of ceftriaxone after nigrostriatal lesion, but prior to and during l‐dopa, may reduce dyskinesia severity without affecting l‐dopa efficacy or the reduction of striatal tyrosine hydroxylase loss. © 2017 International Parkinson and Movement Disorder Society
Dealing with many correlated covariates in capture–recapture models
Authors: Gimenez Olivier , Barbraud Christophe 
Published: June 2017

AbstractCapture–recapture models for estimating demographic parameters allow covariates to be incorporated to better understand population dynamics. However, high‐dimensionality and multicollinearity can hamper estimation and inference. Principal component analysis is incorporated within capture–recapture models and used to reduce the number of predictors into uncorrelated synthetic new variables. Principal components are selected by sequentially assessing their statistical significance. We provide an example on seabird survival to illustrate our approach. Our method requires standard statistical tools, which permits an efficient and easy implementation using standard software.
The Effect of Preoperative Cognitive Behavior and Exercise Therapy for a Patient With an Implanted Left Ventricular Assist Device in Korea
Authors: Seo Yong Gon , Park Won Hah , Jeon Eun Seok , Sung Ji Dong , Jang Mi Ja 
Published: June 2017

AbstractLeft ventricular assist devices (LVADs) are used in patients with progressive heart failure symptoms to provide circulatory support. Patients with LVADs are referred to inpatient cardiac rehabilitation to prevent postoperative complications and improve aerobic capacity and quality of life. Preoperative exercise therapy for cardiac patients is an emerging treatment modality, and several studies have reported that it improves postoperative outcomes, such as length of hospital stay and postoperative complications. This case report describes the benefits of preoperative cognitive behavioral and exercise therapy in a Korean patient undergoing LVAD implantation.Level of EvidenceV
Effect of green tea extract supplementation on glycogen replenishment in exercised human skeletal muscle
Authors: Tsai Tsen-Wei , Chang Chia-Chen , Liao Su-Fen , Liao Yi-Hung , Hou Chien-Wen , Tsao Jung-Piao , Cheng I.-Shiung 
Published: June 2017

AbstractThe purpose of this study was to investigate the effects of 8-week green tea extract (GTE) supplementation on promoting postexercise muscle glycogen resynthesis and systemic energy substrate utilisation in young college students. A total of eight healthy male participants (age: 22·0 (se1·0) years, BMI: 24·2 (se0·7) kg/m2, VO2max: 43·2 (se2·4) ml/kg per min) participated in this study. GTE (500 mg/d for 8 weeks) was compared with placebo in participants in a double-blind/placebo-controlled and crossover study design with an 8-week washout period. Thereafter, all participants performed a 60-min cycling exercise (75 % VO2max) and consumed a carbohydrate-enriched meal immediately after exercise.Vastus lateralismuscle samples were collected immediately (0 h) and 3 h after exercise, and blood and gaseous samples were collected during the 3-h postexercise recovery period. An 8-week oral GTE supplementation had no effects on further promoting muscle glycogen resynthesis in exercised human skeletal muscle, but the exercise-induced muscle GLUT type 4 (GLUT4) protein content was greater in the GTE supplementation trial (P<0·05). We observed that, during the postexercise recovery period, GTE supplementation elicited an increase in energy reliance on fat oxidation compared with the placebo trial (P<0·05), although there were no differences in blood glucose and insulin responses between the two trials. In summary, 8-week oral GTE supplementation increases postexercise systemic fat oxidation and exercise-induced muscle GLUT4 protein content in response to an acute bout of endurance exercise. However, GTE supplementation has no further benefit on promoting muscle glycogen resynthesis during the postexercise period.
Perquenco's Travelling Guitarists and the Administrative Inconsistencies of the Pinochet Dictatorship's Indigenous Policies
Authors: CRAGO SCOTT D. 
Published: June 2017

AbstractThis article analyses the administrative structure and development of Chile's indigenous policies under the dictatorship of Augusto Pinochet (1973–90), taking as its focus a pilot project for indigenous Mapuche integration known as Plan Perquenco. Officials formulated Plan Perquenco in accordance with the Chilean state's new administrative structure known as regionalisation. I focus on the unintended consequences of regionalisation that permitted the Mapuche youth group, Los Guitarreros Caminantes, to work through Plan Perquenco's music programmes to challenge the cultural politics of and justification for the pilot project.
Eating down or simply eating less? The diet and health implications of these practices during pregnancy and postpartum in rural Bangladesh
Authors: Harding Kassandra L , Matias Susana L , Mridha Malay K , Vosti Stephen A , Hussain Sohrab , Dewey Kathryn G , Stewart Christine P 
Published: June 2017

AbstractObjectiveTo: (i) determine the prevalence of self-reported eating less and eating down during early and late pregnancy and postpartum, and explore risk factors associated with eating less; (ii) examine the association between eating less and diet quality; and (iii) determine the association between eating less and weight gain during pregnancy.DesignData were collected longitudinally from a cohort of women participating in a community health programme. Diet was assessed at three time points (≤20 weeks’ gestation, 36 weeks’ gestation, 6 months’ postpartum), body weight was measured during study enrolment (≤20 weeks’ gestation) and at 36 weeks’ gestation, and information about the woman and her household was collected at enrolment.SettingThe Rang-Din Nutrition Study in the Rangpur and Dinajpur districts of Bangladesh.SubjectsWomen (n4011).ResultsThe prevalence of self-reported eating less differed by time point (75·9 % in early pregnancy, 38·8 % in late pregnancy, 7·4 % postpartum;P<0·001). The most common reason for eating less across all time periods was food aversion or loss of appetite. Women who reported eating less in late pregnancy had consumed animal-source foods less frequently in the preceding week than women who reported eating more (mean (sd): 11·7 (7·4)v. 14·8 (9·2) times/week;P<0·001) and had lower weekly weight gain than women who reported eating more (mean (se): 0·27 (0·004)v. 0·33 (0·004) kg/week;P<0·001).ConclusionsEating less has negative implications with respect to diet quality and pregnancy weight gain in this context.
Knochengesunde Ernährung bei Arthrose und Osteoporose
Authors: Siedentopp Uwe 
Published: June 2017

SummaryBei Arthrose und Osteoporose spielt die Ernährung präventiv und therapeutisch eine wesentliche Rolle. Eine integrative Ernährung bildet einen wichtigen Bestandteil eines therapeutischen Gesamtkonzepts.Die gezielte ernährungsmedizinische Anamnese und Diagnostik können individuelle Risikofaktoren aufdecken. Bei Arthrose haben neben der Gewichtsnormalisierung chondroprotektive Knorpelnährstoffe wesentliche Bedeutung sowie die ausreichende Versorgung mit den Vitaminen E, C und D. Kalzium und Vitamin D bilden bei gleichzeitig niedriger Phosphataufnahme die Basis für eine gesunde Knochenstruktur, adjuvant sind Phytoöstrogene empfehlenswert.Die Empfehlungen der chinesischen Diätetik richten sich nach dem jeweiligen Störungsmuster. Sie basieren auf qualitativen Eigenschaften von Lebensmitteln wie Temperaturverhalten, Geschmacksrichtung und Organbezug.Der Artikel stellt die Charakteristika der integrativen Ernährung vor, die quantitative ernährungswissenschaftliche Aspekte sowie qualitative Lebensmittelmerkmale der chinesischen Medizin berücksichtigt.
Intravesikale Salpingiose – Fallbericht und Literaturüberblick
Authors: Gilbert N. , Guo X. , Bauer J. , Hennig M. , Kümpers C. , Merseburger A. 
Published: June 2017

ZusammenfassungDie Endosalpingiose der Harnblase ist eine sehr seltene benigne Erkrankung der Harnblase gekennzeichnet durch das ektope Auftreten von endosalpingialem Gewebe. Das zusätzliche Vorliegen von endozervikalem oder endometrialem Gewebe wird als Müllerianose bezeichnet. In der englischsprachigen Literatur sind ca. 5 reine Endosalpingiose- und 17 Müllerianosefälle beschrieben. Über die Entstehung der Erkrankung existieren zwei Theorien. Während die Implantationstheorie von der Versprengung ektopen Gewebes durch chirurgische Eingriffe ausgeht, propagiert die Metaplasie-Theorie die Neuentstehung durch einen vermeintlichen hormonellen Einfluss. Die Symptomatik der Erkrankung ist ebenso vielfältig wie unspezifisch und kann eine Drangsymptomatik, suprapubische Schmerzen, aber auch Dysurie oder Makrohämaturie beinhalten. Die Beschwerden können zudem zyklisch und zyklusabhängig auftreten.Die Diagnosestellung wird aufgrund der Seltenheit weitestgehend ein Zufallsbefund im Rahmen der zystoskopischen Abklärung dieser Beschwerden bleiben. Eine adäquate Therapie gelingt in der Regel mittels transurethraler Resektion. Allerdings kann es auch bei scheinbar vollständiger Resektion zu Rezidiven kommen, welche zum Teil eventuell einen invasiveren Eingriff nach sich ziehen können.Wir präsentieren die Kasuistik einer 40-jährigen Patientin mit schmerzhafter Makrohämaturie, bei der zufallsbefundlich eine intravesikale Salpingiose nachgewiesen und die in unserer Klinik mittels transurethraler Resektion behandelt wurde. Zudem geben wir einen Überblick über die vorliegende Literatur dieser seltenen intravesikalen Raumforderung.
Bilateral key comparison on luminous flux COOMET.PR-K4.1. final report
Authors: Huriev M , Khlevnoy B , Tolstykh G , Ivashin E , Gorchkova T 
Published: June 2017

This report describes an international bilateral key comparison on luminous flux of tungsten lamps between the National Scientific Centre 'Institute of Metrology' (NSC 'IM', Ukraine) and All-Russian Research Institute for Optical and Physical Measurements (VNIIOFI, Russia). The comparison is intended to determine the Degrees of Equivalence (DoE) for NSC 'IM' and the associated expanded uncertainty. VNIIOFI acts as a laboratory, providing the link to the comparison CCPR-K4. The comparison used a set of tungsten incandescent lamps as a transfer standard with a luminous flux of approximately 3800 lm. The determined DoE of NSC 'IM' is -0.94% with an expanded uncertainty (k = 2) of 1.05%.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCPR, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Using the Revised Centers for Disease Control and Prevention Staging System to Classify Persons Living With Human Immunodeficiency Virus in New York City, 2011–2015
Authors: Xia Qiang , Braunstein Sarah L. , Torian Lucia V. 
Published: June 2017

Abstract
The proportion of persons living with human immunodeficiency virus (HIV) in New York City in stage 1 (CD4 ≥ 500 cells/mm3) increased from 50.6% in 2011 to 59.6% in 2015. The revised Centers for Disease Control and Prevention staging system of HIV infection is a useful tool with which to classify persons living with HIV.
Brief Report: Should Abacavir Be a First-Line Alternative for Adults With HIV in Sub-Saharan Africa?
Authors: Lee Guinevere Q. , McCluskey Suzanne , Boum Yap , Hunt Peter W. , Martin Jeffrey N. , Bangsberg David R. , Gao Xiaojiang , Harrigan P. Richard , Haberer Jessica E. , Siedner Mark J. 
Published: June 2017

Abstract:
Despite a poor toxicity profile, zidovudine supersedes abacavir (ABC) as an alternative first-line agent in most international treatment guidelines because of concerns about HLA-B*57:01-related ABC-hypersensitivity. We detected one case of HLA-B*57:01 carriage among 513 HIV-infected individuals in Uganda, which, in combination with previous reports, supports the safety of ABC in the region.
Dermoscopic features of ocular and extraocular sebaceous carcinomas
Authors: Satomura Hanae , Ogata Dai , Arai Eichi , Tsuchida Tetsuya 
Published: June 2017

AbstractSebaceous carcinomas are rare but potentially fatal malignant adenocarcinomas with varying degrees of sebaceous differentiation. Several dermoscopic findings of extraocular sebaceous carcinomas have been reported; however, there are no previous reports of ocular sebaceous carcinomas detected using dermoscopy. We present a case of ocular sebaceous carcinomas showing specific findings from dermoscopy, and describe the common dermoscopic characteristics. In our cases and a review of cases in the literature, we noted that polymorphous vessels and yellowish areas were observed in all eight cases. Thus, we consider that dermoscopic findings of polymorphous vessels with yellow backgrounds suggest sebaceous carcinoma.