bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrevista com Bernardo Boris Vargaftig
Authors: Vaz Valteir , Bernardini Aurora 
Published: January 2018

Esta entrevista foi realizada com o professor e cientista Bernardo Boris Vargaftig por ocasião do lançamento de sua tradução para o português de Minha vida, versão francesa da autobiografia de Leon Trótski, que culminou com as comemorações do centenário da Revolução Russa de 1917. Boris Vargaftig nasceu na Argentina em 1937, mas passou a maior parte de sua vida no Brasil, onde se formou em medicina pela USP, em 1963. Na época, militante trotskista, chegou a ser preso, mas foi libertado 52 dias depois. Convidado pelo professor Oswaldo Vital Brasil para participar da fundação do Departamento de Farmacologia da Faculdade de Ciências Médicas da UNICAMP, por razões políticas, sua nomeação não se concretizou. Diante da perseguição política, que certamente comprometeria sua atuação profissional, foi morar na França, onde trabalhou nos renomados Instituto Pasteur e Centro Internacional de Pesquisa Merrell, desenvolvendo pesquisas no ramo da farmacologia que o colocaram às portas do Prêmio Nobel de Medicina de 1982.
Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity
Authors: Cuffe Helen , Liu Mingxia , Key Chia-Chi C. , Boudyguina Elena , Sawyer Janet K. , Weckerle Allison , Bashore Alexander , Fried Susan K. , Chung Soonkyu , Parks John S. 
Published: January 2018

Objective—
Adipose tissue cholesterol increases with adipocyte triglyceride content and size during development of obesity. However, how adipocyte cholesterol affects adipocyte function is poorly understood. The aim of this study was to evaluate the role of the cellular cholesterol exporter, Abca1 (ATP-binding cassette transporter A1), on adipose tissue function during diet-induced obesity.

Approach and Results—

Adiponectin
Cre
recombinase transgenic mice were crossed with
Abca1

flox/flox

mice to generate ASKO (adipocyte-specific
Abca1
knockout) mice. Control and ASKO mice were then fed a high-fat, high-cholesterol (45% calories as fat and 0.2% cholesterol) diet for 16 weeks. Compared with control mice, ASKO mice had a 2-fold increase in adipocyte plasma membrane cholesterol content and significantly lower body weight, epididymal fat pad weight, and adipocyte size. ASKO versus control adipose tissue had decreased PPARγ (peroxisome proliferator-activated receptor γ) and CCAAT/enhancer-binding protein expression, nuclear SREBP1 (sterol regulatory element-binding protein 1) protein, lipogenesis, and triglyceride accretion but similar Akt activation after acute insulin stimulation. Acute siRNA-mediated
Abca1
silencing during 3T3L1 adipocyte differentiation reduced adipocyte Abca1 and PPARγ protein expression and triglyceride content. Systemic stimulated triglyceride lipolysis and glucose homeostasis were similar between control and ASKO mice.

Conclusions—
Adipocyte Abca1 is a key regulator of adipocyte lipogenesis and lipid accretion, likely because of increased adipose tissue membrane cholesterol, resulting in decreased activation of lipogenic transcription factors PPARγ and SREBP1.
New Insights into Roman Policy in Judea on the Eve of the Bar Kokhba Revolt
Authors: Ben Zeev Miriam 
Published: January 2018

AbstractThe first years of Hadrian’s reign witness meaningful changes in the Roman policy in Judea, identifiable with the strengthening of military forces, the change of the status of the province to that ofprovincia consularis, the building of new military roads, emphasis on the pagan character of the settlement displayed both in coinage and in new temples devoted to the emperor cult, and the beginning of the preparation works for the building of a Roman colony in Jerusalem. The background of this policy is examined, and its relation with the Diaspora uprisings, which were finally quelled in the late summer of 117.
Turbulent Friction Velocity Calculated from the Reynolds Stress Tensor
Authors: Klipp Cheryl 
Published: January 2018

Abstract
To eliminate the need to correct for instrument tilt, a process that can be problematic in complex terrain, a new way to calculate the turbulent friction velocity is derived based on invariants of the Reynolds stress tensor. In utilizing Reynolds stress tensor invariants, this new method eliminates the need for tilt correction. The friction velocity is calculated without any reference to the wall normal or other terrain features making this method a candidate for future use with data from complex environments. Since this new method is derived from a different theoretical basis than the well-established methods, it is evaluated using data from flat terrain to compare the new method to the standard calculation method, treated here as a baseline truth. For neutral thermal stratification the values calculated using the new method nearly identically match the control values calculated using the standard method. Although for nonneutral stratification the values calculated using the new method do not closely match the values calculated using the standard method, the new friction velocity produces the same dimensionless shear versus dimensionless height Monin–Obukhov scaling relationship over the full range of stabilities as does the standard friction velocity.
Contributing Editor's Feature
Authors: Ronstadt Robert 
Published: January 2018

A decade ago I was fortunate to discover a forgotten gem. The nearly lost item was a short article, originally published in the 1950s. Somehow a faded copy found its way to my desk. The story it contained was the insightful reflections of a very successful but unknown entrepreneur by the name of John Hendrick. In a few precious pages, Mr. Hendrick laid out his life and his eventual, he would say “tortuous,” evolution into a practicing entrepreneur. It wasn't an easy development. All kinds of barriers had to be conquered, some financial, but many others social and psychological. But all these obstacles had a connection, one way or other, to Mr. Hendrick's college experience. Today, in the literature of entrepreneurship, “How I Overcame The Handicap Of A College Education” is a classic.1 It deserves this stature because the article embodies not just the educational experience of John Hendrick, but that of many entrepreneurs who've had to surmount similar barriers posed by an intellectual history and academy that treats business creation and development with unreserved scorn. The author of course never meant to imply that a college education was a bad thing … even for entrepreneurs. John Hendrick was far wiser than that. Nor did he mean to suggest that his liberal arts training at Yale was intrinsically wrong for entrepreneurs. Quite the opposite. In the end, it was this same education that allowed him to puzzle through his problems. But his schooling did have its drawbacks. Now another author, Dennis Ray, shows us how to turn these negative factors into a positive educational experience. Indeed, liberal arts can promote entrepreneurial values and relevant knowledge for future business owners. There is no longer any reason why college should be a handicap.
Canadians Seeking Solutions and Innovations to Overcome Chronic Kidney Disease (Can-SOLVE CKD): Form and Function
Authors: Levin Adeera , Adams Evan , Barrett Brendan J. , Beanlands Heather , Burns Kevin D. , Chiu Helen Hoi-Lun , Chong Kate , Dart Allison , Ferera Jack , Fernandez Nicolas , Fowler Elisabeth , Garg Amit X. , Gilbert Richard , Harris Heather , Harvey Rebecca , Hemmelgarn Brenda , James Matthew , Johnson Jeffrey , Kappel Joanne , Komenda Paul , McCormick Michael , McIntyre Christopher , Mahmud Farid , Pei York , Pollock Graham , Reich Heather , Rosenblum Norman D. , Scholey James , Sochett Etienne , Tang Mila , Tangri Navdeep , Tonelli Marcello , Turner Catherine , Walsh Michael , Woods Cathy , Manns Braden 
Published: January 2018

Purpose of review This article serves to describe the Can-SOLVE CKD network, a program of research projects and infrastructure that has excited patients and given them hope that we can truly transform the care they receive. Issue Chronic kidney disease (CKD) is a complex disorder that affects more than 4 million Canadians and costs the Canadian health care system more than $40 billion per year. The evidence base for guiding care in CKD is small, and even in areas where evidence exists, uptake of evidence into clinical practice has been slow. Compounding these complexities are the variations in outcomes for patients with CKD and difficulties predicting who is most likely to develop complications over time. Clearly these gaps in our knowledge and understanding of CKD need to be filled, but the current state of CKD research is not where it needs to be. A culture of clinical trials and inquiry into the disease is lacking, and much of the existing evidence base addresses the concerns of the researchers but not necessarily those of the patients. Program overview The Canadian Institutes of Health Research (CIHR) has launched the national Strategy for Patient-Oriented Research (SPOR), a coalition of federal, provincial, and territorial partners dedicated to integrating research into care. Canadians Seeking Solutions and Innovations to Overcome Chronic Kidney Disease (Can-SOLVE CKD) is one of five pan-Canadian chronic kidney disease networks supported through the SPOR. The vision of Can-SOLVE CKD is that by 2020 every Canadian with or at high risk for CKD will receive the best recommended care, experience optimal outcomes, and have the opportunity to participate in studies with novel therapies, regardless of age, sex, gender, location, or ethnicity. Program objective The overarching objective of Can-SOLVE CKD is to accelerate the translation of knowledge about CKD into clinical research and practice. By focusing on the patient’s voice and implementing relevant findings in real time, Can-SOLVE CKD will transform the care that CKD patients receive, and will improve kidney health for future generations.
Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients
Authors: Du Jing , Flynn Ryan , Paz Katelyn , Ren Hong-Gang , Ogata Yuko , Zhang Qing , Gafken Philip R. , Storer Barry E. , Roy Nathan H. , Burkhardt Janis K. , Mathews Wendy , Tolar Jakub , Lee Stephanie J. , Blazar Bruce R. , Paczesny Sophie 
Published: January 2018

Key PointsCirculating levels of murine CCL9 and human homolog CCL15 are increased during cGVHD. Targeting CCL9 in vivo reverses murine cGVHD.
Market and political power interactions in Greece: an empirical investigation
Authors: Kollintzas Tryphon , Papageorgiou Dimitris , Tsionas Efthymios , Vassilatos Vanghelis 
Published: January 2018

AbstractIn this paper, using a dynamic panel of 21 OECD countries, we find that, unlike the other OECD countries in the sample, wage setting institutions, competition conditions, public finances, and external imbalances can account for the behavior of the public sector wage premium (WPR) and the self-employed taxation gap (TSL) in Greece and to a lesser extent in Spain and Portugal, in a manner that is consistent with an “insider–outsider society” (IOS). That is, a politicoeconomic system characterized by groups of selfish elites that enjoy market power but at the same time cooperate in influencing government in protecting and promoting their collective self-interests. Then, we find that for Greece as well as Spain and Portugal, WPR and TSL have an adverse effect on both TFP and output growth. Finally, the effect of WPR and TSL on the business cycle (shock propagation mechanism) is investigated via a panel VAR analysis. Again, impulse response function analysis suggests that the shock propagation mechanisms of WPR and TSL for Greece and to a lesser extent for Spain and Portugal are quite different from the rest of the OECD countries. For example, in Greece, unlike the other OECD countries in the sample, a positive temporary shock in WPR causes TFP and output to fall and the public and current account deficits to increase. We take the TFP/output growth and the shock propagation mechanism results to provide strong evidence that Greece and to a lesser extent Spain and Portugal behave like IOS. For that matter, these results are important in order to understand the Greek crisis.
Acquisition of permanent residence by temporary foreign workers in Canada: a panel study of labour market outcomes before and after the status transition
Authors: Ci Wen , Hou Feng , Morissette René 
Published: January 2018

Abstract
Using a unique administrative dataset, this study investigates the employment and earnings trajectories of temporary foreign workers (TFWs) during the years surrounding their acquisition of permanent residence in Canada. If the labour market assimilation of TFWs follows a smooth trajectory in the absence of acquisition of permanent residence, any kinks that occur in employment rates and earnings in or after the year when TFWs become permanent residents might plausibly result from the transition to permanent residence. The main finding of the study is that the labour market outcomes of different groups of TFWs in Canada follow different temporal patterns depending on the TFWs’ skill level and work permit type. Gains in labour market outcomes resulting from the acquisition of permanent residence appear to be greater for holders of an open work permit and for live-in caregivers than for highly skilled TFWs.
The relationship between color cycles in home furnishings and apparel, 1969–2009
Authors: Johnson Olivia , Ulrich Pamela 
Published: January 2018

AbstractFashion is visible in many product categories; color can be an important component in consumers’ product selection decisions. The current phenomenon of fast fashion suggests color cycles have shortened and overlapped between product categories, however no current research has explored the length or speed of color cycles in the current consumer-centric market. Three research questions concerning apparel and home furnishing furnishings were proposed, what (1) parallel color cycles or trends can be identified; (2) are the comparative lengths of color cycles in apparel and home furnishings; and (3) colors exhibited evidence of a time lag between 1969-2009. Content analysis was applied to colors seen in two interiors and two apparel magazines. Few parallel or sequential trends were observed between apparel and home furnishings. Overall, this research showed that color cycles in these consumer product sectors are complex phenomena that deserve more research.
Analysis of Margin Classification Systems for Assessing the Risk of Local Recurrence After Soft Tissue Sarcoma Resection
Authors: Gundle Kenneth R. , Kafchinski Lisa , Gupta Sanjay , Griffin Anthony M. , Dickson Brendan C. , Chung Peter W. , Catton Charles N. , O’Sullivan Brian , Wunder Jay S. , Ferguson Peter C. 
Published: January 2018

Purpose To compare the ability of margin classification systems to determine local recurrence (LR) risk after soft tissue sarcoma (STS) resection. Methods Two thousand two hundred seventeen patients with nonmetastatic extremity and truncal STS treated with surgical resection and multidisciplinary consideration of perioperative radiotherapy were retrospectively reviewed. Margins were coded by residual tumor (R) classification (in which microscopic tumor at inked margin defines R1), the R+1mm classification (in which microscopic tumor within 1 mm of ink defines R1), and the Toronto Margin Context Classification (TMCC; in which positive margins are separated into planned close but positive at critical structures, positive after whoops re-excision, and inadvertent positive margins). Multivariate competing risk regression models were created. Results By R classification, LR rates at 10-year follow-up were 8%, 21%, and 44% in R0, R1, and R2, respectively. R+1mm classification resulted in increased R1 margins (726 v 278, P < .001), but led to decreased LR for R1 margins without changing R0 LR; for R0, the 10-year LR rate was 8% (range, 7% to 10%); for R1, the 10-year LR rate was 12% (10% to 15%) . The TMCC also showed various LR rates among its tiers ( P < .001). LR rates for positive margins on critical structures were not different from R0 at 10 years (11% v 8%, P = .18), whereas inadvertent positive margins had high LR (5-year, 28% [95% CI, 19% to 37%]; 10-year, 35% [95% CI, 25% to 46%]; P < .001). Conclusion The R classification identified three distinct risk levels for LR in STS. An R+1mm classification reduced LR differences between R1 and R0, suggesting that a negative but < 1-mm margin may be adequate with multidisciplinary treatment. The TMCC provides additional stratification of positive margins that may aid in surgical planning and patient education.
Bevacizumab Maintenance Versus No Maintenance During Chemotherapy-Free Intervals in Metastatic Colorectal Cancer: A Randomized Phase III Trial (PRODIGE 9)
Authors: Aparicio Thomas , Ghiringhelli Francois , Boige Valérie , Le Malicot Karine , Taieb Julien , Bouché Olivier , Phelip Jean-Marc , François Eric , Borel Christian , Faroux Roger , Dahan Laetitia , Jacquot Stéphane , Genet Dominique , Khemissa Faiza , Suc Etienne , Desseigne Françoise , Texereau Patrick , Lepage Come , Bennouna Jaafar ,   PRODIGE 9 Investigators
Published: January 2018

Purpose Conflicting results are reported for maintenance treatment with bevacizumab during chemotherapy-free intervals (CFI) in metastatic colorectal cancer after induction chemotherapy. Patients and Methods In this open-label, phase III, randomized controlled trial, we compared the tumor control duration (TCD) observed with bevacizumab maintenance and with no treatment (observation) during CFI subsequent to induction chemotherapy with 12 cycles of fluorouracil, leucovorin, and irinotecan plus bevacizumab. After disease progression, the induction regimen was repeated for eight cycles, followed by a new CFI. Results From March 2010 to July 2013, 491 patients were randomly assigned. Disease progression or death occurred during induction chemotherapy in 85 patients (17%); 261 patients (53%) had at least one reinduction, 107 (22%) had two reinductions, and 56 (11%) had three or more reinductions. The median TCD was 15 months in both groups; the median progression-free survival (PFS) from randomization was 9.2 and 8.9 months in the maintenance group and observation groups, respectively. The TCD observed in both groups was higher compared with the TCD hypotheses of the trial. The median overall survival (OS) was 21.7 and 22.0 months in the maintenance and observation groups, respectively. In the per-protocol population, defined as patients with at least one reinduction after the first progression, the median duration of the first CFI was 4.3 months in both arms; the median TCD was 17.8 and 23.3 months ( P = .339), the median PFS was 9.9 and 9.5 months, and the median OS was 27.6 and 28.5 months in the maintenance and observation groups, respectively. Multivariable analysis revealed that female gender, WHO performance status ≥ 2, and unresected primary tumors were associated with a shorter TCD. Conclusion Bevacizumab maintenance monotherapy did not improve TCD, CFI duration, PFS, or OS.
Growth of human breast cancers in Peromyscus
Authors: Kaza Vimala , Farmaki Elena , Havighorst Amanda , Crossland Janet , Chatzistamou Ioulia , Kiaris Hippokratis 
Published: January 2018

ABSTRACT
Modeling breast cancer in general and hormone-sensitive breast cancer, in particular in mice, has several limitations. These are related to the inbred nature of laboratory mice, and do not allow adequate appreciation of the contribution of the host's genetic heterogeneity in tumor growth. In addition, the naturally low estrogen levels of mice makes estradiol supplementation obligatory for tumor growth. Here, we show that Peromyscus californicus, following cyclosporine-mediated immunosuppression, supports the growth of both MDA-MB-231 estrogen-independent and MCF7 estrogen receptor-positive breast cancers without exogenous estradiol supplementation. Tumor growth was inhibited by fulvestrant or letrozole, confirming that MCF7 xenografts remain hormone dependent in vivo and suggesting that P. californicus can be used as an alternative to conventional mice for the study of hormone-sensitive breast cancer. The fact that Peromyscus stocks are outbred also facilitates the study of breast cancer in genetically heterogenous populations.
Changes in radiotherapy fractionation—breast cancer
Authors: Yarnold John 
Published: January 2018

Conventional fractionation for half a century has been justified on the basis that 2.0 Gy fractions spare dose-limiting late-responding normal tissues to a greater degree than cancerous tissues. Early indications that breast cancer responds more strongly to fraction size than many other common cancers were followed several decades of investigation, but there is now reliable Level I evidence that this is the case. Four randomised trials testing fraction sizes in the range 2.7–3.3 Gy have reported 10-year follow up in almost 8000 patients, and they provide robust estimates of α/β in the range of 3 Gy. The implication is that there are no advantages in terms of safety or effectiveness of persisting with 2.0 Gy fractions in patients with breast cancer. 15- or 16-fraction schedules are replacing the conventional 25-fraction regimen as a standard of care for adjuvant therapy in an increasing number of countries. A number of concerns relating to the appropriateness of hypofractionation in patient subgroups, including those treated post-mastectomy, advanced local-regional disease and/or to lymphatic pathways are addressed. Meanwhile, hypofractionation can be exploited to modulate dose intensity across the breast according to relapse risk by varying fraction size across the treatment volume. The lower limits of hypofractionation are currently being explored, one approach testing a 5-fraction schedule of local-regional radiotherapy delivered in 1 week.
The Construction of Universal Knowledge in the Tango Scene at the Beginning of the 21st Century. The Orlando Goñi School Experience
Authors: Gonnet Daniel H. 
Published: January 2018

This article focuses on the genesis of a cooperative school born from historical needs in the Buenos Aires tango of the 1990s. In a musical scene dominated by the rules of the game of neoliberalism, the tango lived a revitalised renaissance by a “neo-contentiousness” in public milieus with voluntary donations. In this co-management modality, a proper way of circulating knowledge was structured. Defined by one of its founders as “very little formal, but very serious”, the Orlando Goñi School constitutes a successful experience in the construction and circulation of knowledge in the language of tango. This work aims to characterize the Goñi School as a decolonial experience, based on the analysis of the main features of its genesis process, as well as on the progressive identity and institutionalization by means of precepts and norms, taking as a starting point the conversation with Julián Peralta, one of the founders, teacher, cultural manager and renowned tango musician of the last twenty years.