bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asuhan Kebidanan Berkelanjutan Pada Ny. E di PMB Essy Novia, SKM., M.M
Authors: Giyarmi Resti Dian , Sanjaya Riona , Fabella Ayu Vera , Yuliasari Riting , Rosmianah Rosmianah , Suharni Suharni , Sari Anggri Melian , Kurniasari Nita , Wardani Psiari Kusuma 
Published: October 2024

ABSTRAK Asuhan Kebidanan Berkelanjutan Pada Ny. E di PMB Essy Novia, SKM., M.M. Data statistik menunjukkan adanya penurunan yang signifikan dalam angka kematian ibu di Indonesia dari 390 menjadi 189 per 100.000 kelahiran hidup. Penurunan ini hampir mencapai target yang ditetapkan dalam Rencana Pembangunan Jangka Menengah Nasional (RPJMN) tahun 2024. Meskipun terjadi penurunan dalam angka kematian ibu, akan tetapi belum memenuhi target global yang ditetapkan oleh Sustainable Development Goals (SGDs). Sehingga membutuhkan pendekatan Continuity of Care (COC) sebagai prinsip utama dalam pelayanan kesehatan maternal. penelitian ini bertujuan untuk melakukan asuhan berkelanjutan dari masa kehamilan sampai pasca persalinan. Selain itu akan dilakukan asuhan secara komprehensif mulai dari masa kehamilan dengan asuhan pemberian massage effleurage, persalinan dengan asuhan relaksasi nafas dalam pada ibu inpartu kala 1 fase aktif, nifas dengan asuhan pemberian pijat oksitosin, bayi, serta keluarga berencana dengan asuhan KB suntik 3 bulan. Metode penelitian yang digunakan adalah penelitian deskriptif dengan menggunakan metode studi kasus. Pada kasus ini menggunakan jenis penelitian deskriptif dengan menggunakan tujuh langkah Varney dan pendekatan SOAP asuhan continuity of care sejak masa kehamilan hingga KB. Hasil penelitian menunjukkan adanya peningkatan yang signifikan dalam penurunan skala nyeri punggung dan persalinan setelah pemberian intervensi. Selain itu, terjadi peningkatan dalam produksi ASI setelah penggunaan pijat oksitosin pada ibu nifas. Temuan ini menunjukkan efektivitas dari intervensi yang diberikan dalam mengatasi masalah yang dialami oleh Ny. E selama proses kehamilan, persalinan, dan masa nifas.Kata Kunci: Continuity of Care, massage effleurage, nyeri punggung, relaksasi nafas, nyeri persalinan
PERBEDAAN TINGKAT PENGETAHUAN TERHADAP PERILAKU KESEHATAN GIGI DAN MULUT SELAMA KEHAMILAN DI PUSKESMAS BANJAR BARU KABUPATEN TULANG BAWANG
Authors: Ifayanti Hikmah , Isadora Orien , Apriyanti Rina , Alfi Fauziah Nur , Isnaini Maulia , Ariyani Fitri 
Published: October 2024

Kesehatan mulut yang buruk selama kehamilan telah dikaitkan dengan gangguan gizi, masalah dalam sistem pencernaan, kelahiran prematur, dan berat badan lahir rendah. Kasus kesehatan gigi dan mulut di Puskesmas Banjar Baru sebanyak 7 (100%) ibu tidak mengetahui bahwa saat kehamilan, terjadi perubahan hormon yang dapat menyebabkan perubahan pada kesehatan gigi dan mulut. Hal yang harus dilakukan oleh ibu hamil berkaitan dengan kebersihan gigi dan mulut antara lain adalah memeriksakan diri ke dokter gigi minimal sekali selama kehamilan, mengkonsumsi makanan yang mengandung kalsium, jika perlu konsumsi suplementasi kalsium. Tujuan penelitian diketahui perbedaan tingkat pengetahuan terhadap perilaku terhadap kesehatan gigi dan mulut selama kehamilan di Puskesmas Banjar Baru. Jenis penelitian ini kuantitatif dengan rancangan penelitian cross sectional. Populasi dalam penelitian ini adalah ibu hamil di Puskesmas Banjar Baru sebanayk 118 ibu hamil dengan sampel yang digunakan sebanyak 55 responden menggunakan teknik purposive sampling. Penelitian telah dilakukan di Puskesmas Banjar Baru pada bulan Mei – Juni 2024. Pengumpulan data menggunakan lembar kuesioner. Analisis data secara univariat dan bivariat (chi square). Hasil penelitian diketahui sebanyak 67,3% responden dengan pengetahuan baik dan sebanyak 63,6% responden dengan perilaku kesehatan gigi dan mulut baik. Ada hubungan tingkat pengetahuan dengan perilaku terhadap kesehatan gigi dan mulut selama kehamilan di Puskesmas Banjar Baru (p-value 0,001). Saran tenaga kesehatan agar dapat memberikan penyuluhan kepada ibu hamil pada saat periksa kehamilan untuk melakukan pemeriksaan kesehatan gigi dan mulut sebanyak 2 kali selama kehamilan pada saat trimester pertama dan trimester ketiga
Integritas kristiani: Keseimbangan dalam hidup menggereja pada ruang eklesial-sosial
Authors: Togatorop Timotius Mangiring Tua , Widjaja Fransiskus Irwan 
Published: October 2024

Christian integrity faces the challenges of church life in social and ecclesial spaces; both reflect one standard. Presence in social spaces, especially in the digital world, presents a dramaturgical lifestyle or, like, playing a role so that it tends to be manipulative. This article aims to build a theological concept of Christian integrity reflected through church life in ecclesial and social spaces. Using a literature study approach, through published research articles, we find that church life must always display the same face of Christ in all spaces or dimensions of life. This means that Christian integrity is the spirit of church life in the ecclesial-social sphere.

Abstrak
Integritas kristiani diperhadapkan pada tantangan hidup menggereja pada ruang sosial dan eklesial; apakah keduanya mereleksikan satu standar. Kehadiran pada ruang sosial, khususnya di dunia digital, menghadirkan gaya hidup yang dramaturgis atau seperti bermain peran sehingga cenderung manipulatif. Artikel ini bertujuan untuk membangun konsep teologis tentang integritas kristiani yang tercermin melalui hidup menggereja pada ruang eklesial dan sosial. Dengan menggunakan pendekatan studi pustaka, melalui artikel hasil riset yang dipublikasi, kami mendapatkan bahwa kehidupan gereja harus selalu menampilkan wajah Kristus yang sama di segala ruang atau dimensi kehidupan. Ini berarti, integritas kristiani selalu menjadi spirit dalam hidup menggereja di ruang eklesial-sosial
Digital storytelling: Menstimulasi minat spiritualitas pada anak Generasi Alfa di era posdigital
Authors: Sidabutar Dewi Lidya , Prasetya Didimus Sutanto B. 
Published: October 2024

The issue of the spirituality of Generation Alpha children must start by mapping their digital-based interests. One way to increase interest in the process of learning Christian education is through a storytelling approach. This article offers digital-based storytelling to build and develop the spiritual interests of Generation Alpha children. This article uses a literature study through descriptive searches on various research references on storytelling and Generation Alpha in the post-digital era. Research shows the power of storytelling in improving the abilities of Generation Alpha children. We conclude that the spirituality of Generation Alpha begins with the interest in spirituality itself, which can be stimulated through digital storytelling.

Abstrak
Persoalan spiritualitas anak generasi Alfa harus dimulai dari memetakan minat mereka yang berbasis digital. Salah satu cara untuk meningkatkan minat dalam proses belajar pendidikan kristiani adalah dengan pendekatan storytelling. Artikel ini bertujuan untuk menawarkan penggunaan storytelling bebasis digital guna membangun hingga mengembangkan minat spiritualitas anak generasi Alfa. Artikel ini menggunakan studi pustaka, melalui penelusuran secara deskriptif pada berbagai referensi hasil riset tentang storytelling dan generasi Alfa di era posdigital. Penelusuran riset memperlihatkan kekuatan storytelling dalam meningkatkan kemampuan anak generasi Alfa. Kami menyimpulkan bahwa spiritualitas generasi Alfa dimulai dari minat spiritualitas itu sendiri, yang dapat distimulasi melalaui digital storytelling.
स्नातक तहको अनुसन्धान विधि पाठ्यांश प्रति शिक्षकको दृष्टिकोण
Authors: देवी खड्का सृजना 
Published: October 2024

प्रस्तुत लेखमा त्रिभुवन विश्वविद्यालय शिक्षाशास्त्र सङ्कायअन्तर्गत सञ्चालित चार बर्से बि. एड्को पाठ्यांश (२०७५) को संरचनाअनुसार नेपाली शिक्षा विशिष्टीकरणका पाठ्यांशमध्ये अनुसन्धान विधि (ने.पा.शि. ४४५) मा केन्द्रित भएर यस विषयप्रति शिक्षकको दृष्टिकोण पत्ता लगाउने उद्देश्यले तयार पारिएको हो । यसमा उपत्यकाभित्र र बाहिरका आङ्गिक र सामुदायिक क्याम्पसमा स्नातक र स्नातकोत्तर तहमा प्राध्यापन गर्ने २० जना शिक्षकलाई मात्र नमुनाको रूपमा लिएको छ । यो पाठ्यांशप्रति शिक्षकको धारणा पहिचान गरी यस पाठ्यांशको सैद्धान्तिक र कार्यान्वयन अवस्था जानकारी गराउनु यस अध्ययनको मुख्य समस्या हो । यसमा पोस्टपोजिटिभ प्याराडाइम ढाँचामा आबद्ध रही अर्धसंरचनात्मक प्रकृतिका केही बन्द प्रश्नावली निर्माण गरी स्थलगत भ्रमण र केही टेलिफोनमा अन्तर्वार्ता विधिको प्रयोग गरी तथ्याङ्क सङ्कलन गरिएको छ । यस अध्ययनको प्राप्तिअनुसार यो विषय समय सान्दर्भिक छ भन्ने धारणामा सबै भन्दा धेरै १०० प्रतिशत अभिमत प्राप्त भएको छ । कक्षाकोठामा विद्यार्थीको सिकाइ क्रियाकलापमा सहभागिताप्रति केही सन्तुष्ट छु भन्ने धारणामा पनि १०० प्रतिशत अभिमत प्राप्त भएको छ। पाठ्यांशमा उल्लेखित सन्दर्भ पुस्तक केही प्राप्य छन् भन्ने धारणामा ९० प्रतिशत अभिमत परेको छ। । अध्ययनपत्र मूल्याङ्कन अङ्कभारप्रतिको धारणा लिँदा केही उपयुक्त छ भन्ने धारणामा ५० प्रतिशत अभिमत परेको छ भने अनुपयुक्त छ भन्नेमा २० प्रतिशत अभिमत परेको छ। । अन्य धारणालाई हेर्दा धेरैजसो मध्यम र केही उपयुक्त छ भन्नेमा अभिमत देखिएको छ । पाठ्यक्रमलाई बाटो देखाउने गाइडको रूपमा लिने भएकाले समय सान्दर्भिक मानिएको अनुसन्धान विधि पाठ्यांशमा कमजोर देखिएका पक्षलाई समेटी केही परिमार्जन गर्नुपर्ने देखिएको छ । पाठ्यांश निर्माण कार्यमा संलग्न विषयविज्ञ तथा सरोकारवालालाई यस अध्ययनले सहयोग पुग्ने देखिएको छ ।
Treatment with novel topoisomerase inhibitors in Ewing sarcoma models reveals heterogeneity of tumor response
Authors: Lee Unsun , Szabova Ludmila , Collins Victor J. , Gordon Melanie , Johnson Kristine , Householder Deborah , Jorgensen Stephanie , Lu Lucy , Bassel Laura , Elloumi Fathi , Peer Cody J. , Nelson Ariana E. , Varriano Sophia , Varma Sudhir , Roberts Ryan D. , Ohler Zoe Weaver , Figg William D. , Sharan Shyam K. , Pommier Yves , Heske Christine M. 
Published: October 2024

IntroductionThe topoisomerase 1 (TOP1) inhibitor irinotecan is a standard-of-care agent for relapsed Ewing sarcoma (EWS), but its efficacy is limited by chemical instability, rapid clearance and reversibility, and dose-limiting toxicities, such as diarrhea. Indenoisoquinolines (IIQs) represent a new class of clinical TOP1 inhibitors designed to address these limitations.MethodsIn this study, we evaluated the preclinical efficacy of three IIQs (LMP400, LMP744, and LMP776) in relevant models of EWS. We characterized the pharmacokinetics of IIQs in orthotopic xenograft models of EWS, optimized the dosing regimen through tolerability studies, and tested the efficacy of IIQs in a panel of six molecularly heterogeneous EWS patient-derived xenograft (PDX) models. For each PDX, we conducted whole genome and RNA sequencing, and methylation analysis.ResultsWe show that IIQs potently inhibit the proliferation of EWS cells in vitro, inducing complete cell growth inhibition at nanomolar concentrations via induction of DNA damage and apoptotic cell death. LMP400 treatment induced ≥30% tumor regression in two of six PDX models, with more durable regression compared to irinotecan treatment in one of these models. RNA sequencing of PDX models identified a candidate predictive biomarker gene signature for LMP400 response. These data, along with pharmacogenomic data on IIQs in sarcoma cell lines, are available at a new interactive public website: https://discover.nci.nih.gov/rsconnect/EwingSarcomaMinerCDB/.DiscussionOur findings suggest that IIQs may be promising new agents for a subset of EWS patients.
Degradation of malachite green by UV/H2O2 and UV/H2O2/Fe2+ processes: kinetics and mechanism
Authors: Wilayat Sumaira , Fazil Perveen , Khan Javed Ali , Zada Amir , Ali Shah Muhammad Ishaq , Al-Anazi Abdulaziz , Shah Noor S. , Han Changseok , Ateeq Muhammad 
Published: October 2024

This work investigated the photochemical degradation of malachite green (MG), a cationic triphenylmethane dye used as a coloring agent, fungicide, and antiseptic. UV photolysis was ineffective in the removal of MG as only 12.35% degradation of MG (10 mg/L) was achieved after 60 min of irradiation. In contrast, 100.00% degradation of MG (10 mg/L) was observed after 60 min of irradiation in the presence of 10 mM H2O2 by UV/H2O2 at pH 6.0. Similarly, complete removal (100.00%) of MG was observed at 30 min of the reaction time by UV/H2O2/Fe2+ employing [MG]0 = 10 mg/L, [H2O2]0 = 10 mM, [Fe2+]0 = 2.5 mg/L, and [pH]0 = 3.0. For the UV/H2O2 process, the degradation efficiency was higher at pH 6.0 than at pH 3.0 as the kobs values were 0.0873 and 0.0690 min−1, respectively. However, UV/H2O2/Fe2+ showed higher reactivity at pH 3.0 than at pH 6.0. Chloride and nitrate ions slightly inhibited the removal efficiency of MG by both UV/H2O2 and UV/H2O2/Fe2+ processes. Moreover, three degradation products (DPs) of MG, (i) 4-dimethylamino-benzophenone (DABP), (ii) 4-amino-benzophenone (ABP), and (iii) 4-dimethylamino-phenol (DAP), were identified by GC-MS during the UV/H2O2 treatment. These DPs were found to demonstrate higher aquatic toxicity than the parent MG, suggesting that researchers should focus on the removal of target pollutants as well as their DPs. Nevertheless, the results of this study indicate that both UV/H2O2 and UV/H2O2/Fe2+ processes could be implemented to alleviate the harmful environmental impacts of dye and textile industries.
Phenotypic and genetic characterization of daptomycin non-susceptible Staphylococcus aureus strains selected by adaptive laboratory evolution
Authors: Xu Yanlei , Xiao Yanghua , Zhao Huilin , Wang Bingjie , Yu Jingyi , Shang Yongpeng , Zhou Ying , Wu Xiaocui , Guo Yinjuan , Yu Fangyou 
Published: October 2024

BackgroundDaptomycin non-susceptible Staphylococcus aureus (DNS) strains pose a serious clinical threat, yet their characteristics remain poorly understood.MethodsDNS derivatives were generated by exposing S. aureus strains to subinhibitory concentrations of daptomycin. Competition experiment and growth kinetics experiment were used to observe the growth of bacteria. Galleria mellonella larvae and mouse skin abscess models were used to observe the virulence of bacteria. Transmission electron microscopy (TEM), cytochrome C experiment and biofilm formation experiment were used to observe the drug resistance phenotype. And homologous recombination was used to study the role of mutations.ResultsPhenotypic profiling of DNS strains revealed impaired growth, increased cell wall thickness, enhanced biofilm formation, reduced negative surface charge, and attenuated virulence compared to their wild-type strains. Whole genome sequencing identified mutations in mprF, cls2, and saeR in DNS strains. Allelic replacement experiments validated the roles of MprF L341F and Cls2 F60S substitutions in augmenting daptomycin non-susceptibility in Newman. Deletion of saeR in the NewmanMprFL341F strain and complementation of saeR in the Newman-DNS strain did not directly alter daptomycin susceptibility. However, the deletion of saeR was found to enhance competitive fitness under daptomycin pressure.ConclusionThis work validates adaptive laboratory evolution (ALE) for modeling clinical DNS strains and uncovers contributions of mprF, cls2, and saeR mutations to the adaptation and resistance mechanisms of S. aureus against daptomycin. These findings enrich our understanding of how S. aureus acquired resistance to daptomycin, thus paving the way for the development of more effective treatment strategies and offering potential molecular markers for resistance surveillance.
Association between gout and kidney stone: results from mendelian randomization and the NHANES study
Authors: Jin Shengkai , Geng Haochen , Lu Yichen , Zhou Yuhua , Lv Jing , Fu Chaowei , Zhang Yuwei , Li Menglu , Feng Ninghan 
Published: October 2024

BackgroundKidney stones are a common urologic disease with an increasing incidence year by year, and there are similar influences between gout status and kidney stone incidence. Therefore the contribution of gout status to the incidence of kidney stones is unclear. The aim of this study was to investigate the relationship between gout status and kidney stones and to further explore the causal relationship by Mendelian randomization (MR) analysis.MethodAn epidemiologic study of 49,693 participants in the 2009–2018 National Health and Nutrition Examination Survey (NHANES) was conducted to examine the association between the two. The causal relationship between gout status and kidney stones was assessed by Mendelian randomization analysis of data from the GWAS database.ResultA total of 28,742 participants were included in the NHANES analysis. We found that gout status was associated with an increased risk of kidney stones [odds ratio (OR) = 1.45 (95%CI, 1.243–1.692); p &lt; 0.001]. In the MR analysis, we found a causal relationship between gout status and the risk of developing kidney stones (OR = 1.047, 95%CI, 1.011–1.085, p = 0.009).ConclusionThere may be an association between gout status and kidney stone risk. This finding requires further large-sample studies and adequate follow-up.
Epstein-Barr virus-specific T-cell response in pediatric liver transplant recipients: a cross-sectional study by multiparametric flow cytometry
Authors: Cuesta-Martín de la Cámara Ricardo , Torices-Pajares Andrea , Miguel-Berenguel Laura , Reche-Yebra Keren , Frauca-Remacha Esteban , Hierro-Llanillo Loreto , Muñoz-Bartolo Gema , Lledín-Barbacho María Dolores , Gutiérrez-Arroyo Almudena , Martínez-Feito Ana , López-Granados Eduardo , Sánchez-Zapardiel Elena 
Published: October 2024

BackgroundEpstein-Barr virus (EBV) specific T-cell response measurement can help adjust immunosuppression in transplant patients with persistent infections. We aim to define T-cell responses against EBV in a cohort of pediatric liver-transplant patients.MethodsThirty-eight immunosuppressed pediatric liver-transplant patients (IP) and 25 EBV-seropositive healthy-adult controls (HC) were included in our cross-sectional study. Based on their EBV serological (S) and viral load (VL) status, patients were categorized into IP-SNEG, IP-SPOSVLNEG and IP-SPOSVLPOS groups. T-cell response was assessed at two timepoints by stimulating cells with EBV peptides (PepTivator®) and performing intracellular-cytokine and activation-induced marker staining. Background subtraction was used to determine EBV-specific T-lymphocyte frequency.ResultsPolyfunctional CD8+ T cells indicated previous EBV contact (IP-SNEG 0.00% vs IP-SPOS 0.04% and HC 0.02%; p=0.001 and p=0.01, respectively). Polyfunctional CD8+CD107a+IFNɣ+IL2-TNFα- profile was increased in serology-positive (IP-SNEG 0.01% vs IP-SPOS 0.13% and HC 0.03%; p=0.01 and p=0.50, respectively) and viral-load positive (IP-SPOSVLPOS 0.43% vs IP-SPOSVLNEG 0.07% and HC 0.03%; p=0.03 and p=0.001, respectively) patients. Central-memory cells were increased among serology-positive adults (IP-SNEG 0.00% vs IP-SPOS 0.13% and HC 4.33%; p=0.58 and p=0.002, respectively). At the second timepoint, IP-SNEG patients remained negative (first visit 0.01% vs second visit 0.00%, p=0.44). On the other hand, IP-SPOSVLPOS patients had cleared viral loads and, subsequently, decreased polyfunctional CD8+CD107a+IFNɣ+IL2-TNFα- cells (first visit 0.43% vs second visit 0.10%, p=0.81).ConclusionPolyfunctional CD8+ EBV-specific T-cell response allows detecting EBV previous contact in liver-transplant children. %CD8+CD107a+IFNɣ+IL2-TNFα- is increased in patients with positive viral loads. Central memory CD4+ T-cell population more effectively determines prior EBV-exposure in adults.
68-channel neural signal processing system-on-chip with integrated feature extraction, compression, and hardware accelerators for neuroprosthetics in 22 nm FDSOI
Authors: Guo Liyuan , Weiße Annika , Zeinolabedin Seyed Mohammad Ali , Schüffny Franz Marcus , Stolba Marco , Ma Qier , Wang Zhuo , Scholze Stefan , Dixius Andreas , Berthel Marc , Partzsch Johannes , Walter Dennis , Ellguth Georg , Höppner Sebastian , George Richard , Mayr Christian 
Published: October 2024

IntroductionMulti-channel electrophysiology systems for recording of neuronal activity face significant data throughput limitations, hampering real-time, data-informed experiments. These limitations impact both experimental neurobiology research and next-generation neuroprosthetics.MethodsWe present a novel solution that leverages the high integration density of 22nm fully-depleted silicon-on-insulator technology to address these challenges. The proposed highly integrated programmable System-on-Chip (SoC) comprises 68-channel 0.41 μW/Ch recording frontends, spike detectors, 16-channel 0.87–4.39 μW/Ch action potentials and 8-channel 0.32 μW/Ch local field potential codecs, as well as a multiply-accumulate-assisted power-efficient processor operating at 25 MHz (5.19 μW/MHz). The system supports on-chip training processes for compression, training, and inference for neural spike sorting. The spike sorting achieves an average accuracy of 91.48 or 94.12% depending on the utilized features. The proposed programmable SoC is optimized for reduced area (9 mm2) and power. On-chip processing and compression capabilities free up the data bottlenecks in data transmission (up to 91% space saving ratio), and moreover enable a fully autonomous yet flexible processor-driven operation.DiscussionCombined, these design considerations overcome data-bottlenecks by allowing on-chip feature extraction and subsequent compression.
Association of non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) with gout prevalence: a cross-sectional study
Authors: Guo Xia , Chu Haoxuan , Xu Hanchi , Wang Shipeng , He Jiahuan , Wang Yushi 
Published: October 2024

BackgroundThe non-high-density lipoprotein cholesterol (non-HDL-C)-to-high-density lipoprotein cholesterol (HDL-C) ratio (NHHR) is a strong lipid marker that has been associated with atherogenic features. This study aimed to investigate the potential association between the NHHR and gout prevalence.MethodsThis study investigated the relationship between the NHHR and gout by analyzing data gathered from the National Health and Nutrition Examination Survey (NHANES), a research study conducted in the United States from 2007 to 2018. All participants in NHANES provided written informed consent prior to participation. The NHHR was calculated as the ratio of non-HDL-C to HDL-C. Total cholesterol (TC) and HDL-C levels were sourced from NHANES laboratory data. Gout was assessed using a questionnaire. Weighted logistic regression analysis, subgroup analysis, and smoothed curve fitting were performed.ResultsThis study included 30,482 participants. The fully adjusted models showed that for each unit increase in NHHR in continuous variables, there was a 10% higher likelihood of gout prevalence (OR: 1.10, 95% CI: 1.05, 1.16). Analysis of the NHHR quartiles revealed that patients in the highest quartile had a notably greater probability of developing gout than those in the lowest quartile. (Q4 vs. Q1, OR: 1.34, 95% CI: 1.05, 1.71). Subgroup analyses yielded consistent results across categories, indicating a significant positive association between the NHHR and gout. E-value analysis suggested robustness to unmeasured confounding. Interaction tests showed that the race, education level, marital relationship, poverty-income ratio (PIR), hypertension, smoking habits, estimated glomerular filtration rate (eGFR), lipid-lowering therapy, and diabetes had no discernible effects on this association. The p-values for all the interactions were &gt; 0.05. Nevertheless, the relationship between the NHHR and gout was significantly affected by the age and sex of the participants (interaction p &lt; 0.05).ConclusionAmong adults in the United States, elevated NHHR levels are correlated with increased odds of gout prevalence.