bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Follow-Up of the French Stop Imatinib (STIM1) Study in Patients With Chronic Myeloid Leukemia
Authors: Etienne Gabriel , Guilhot Joëlle , Rea Delphine , Rigal-Huguet Françoise , Nicolini Franck , Charbonnier Aude , Guerci-Bresler Agnès , Legros Laurence , Varet Bruno , Gardembas Martine , Dubruille Viviane , Tulliez Michel , Noel Marie-Pierre , Ianotto Jean-Christophe , Villemagne Bruno , Carré Martin , Guilhot François , Rousselot Philippe , Mahon François-Xavier 
Published: October 2016

Purpose Imatinib (IM) can safely be discontinued in patients with chronic myeloid leukemia (CML) who have had undetectable minimal residual disease (UMRD) for at least 2 years. We report the final results of the Stop Imatinib (STIM1) study with a long follow-up. Patients and Methods IM was prospectively discontinued in 100 patients with CML with UMRD sustained for at least 2 years. Molecular recurrence (MR) was defined as positivity of BCR-ABL transcript in a quantitative reverse transcriptase polymerase chain reaction assay confirmed by a second analysis point that indicated an increase of one log in relation to the first analysis point at two successive assessments or loss of major molecular response at one point. Results The median molecular follow-up after treatment discontinuation was 77 months (range, 9 to 95 months). Sixty-one patients lost UMRD after a median of 2.5 months (range, 1 to 22 months), and one patient died with UMRD at 10 months. Molecular recurrence-free survival was 43% (95% CI, 33% to 52%) at 6 months and 38% (95% CI, 29% to 47%) at 60 months. Treatment was restarted in 57 of 61 patients with MR, and 55 patients achieved a second UMRD with a median time of 4 months (range, 1 to 16 months). None of the patients experienced a CML progression. Analyses of the characteristics of the study population identified that the Sokal risk score and duration of IM treatment were significantly associated with the probability of MR. Conclusion With a median follow-up of more than 6 years after treatment discontinuation, the STIM1 study demonstrates that IM can safely be discontinued in patients with a sustained deep molecular response with no late MR.
Is a Normal TSH Synonymous With “Euthyroidism” in Levothyroxine Monotherapy?
Authors: Peterson Sarah J. , McAninch Elizabeth A. , Bianco Antonio C. 
Published: October 2016

Context:
Levothyroxine (LT4) monotherapy is the standard of care for hypothyroidism.

Objective:
To determine whether LT4 at doses that normalize the serum TSH is associated with normal markers of thyroid status.

Design:
Cross-sectional data from the US National Health and Nutrition Examination Survey (2001–2012) was used to evaluate 52 clinical parameters. LT4 users were compared to healthy controls and controls matched for age, sex, race, and serum TSH. Regression was used to evaluate for correlation with T4 and T3 levels.

Participants:
A total of 9981 participants with normal serum TSH were identified; 469 were LT4-treated.

Results:
Participants using LT4 had higher serum total and free T4 and lower serum total and free T3 than healthy or matched controls. This translated to approximately 15–20% lower serum T3:T4 ratios in LT4 treatment, as has been shown in other cohorts. In comparison to matched controls, LT4-treated participants had higher body mass index despite report of consuming fewer calories/day/kg; were more likely to be taking beta-blockers, statins, and antidepressants; and reported lower total metabolic equivalents. A serum TSH level below the mean in LT4-treated participants was associated with a higher serum free T4 but similar free and total T3; yet those with lower serum TSH levels exhibited higher serum high-density lipoprotein and lower serum low-density lipoprotein, triglycerides, and C-reactive protein. Age was negatively associated with serum free T3:free T4 ratio in all participants; caloric intake was positively associated in LT4-treated individuals.

Conclusions:
In a large population study, participants using LT4 exhibited lower serum T3:T4 ratios and differed in 12/52 objective and subjective measures.
Massive Transfusion Protocols: A Survey of Academic Medical Centers in the United States
Authors: Treml Angela B. , Gorlin Jed B. , Dutton Richard P. , Scavone Barbara M. 
Published: October 2016

BACKGROUND:
Massive transfusion protocols (MTPs) have been adopted in many hospitals, and they may improve outcomes, as well as decrease the number of blood products transfused. However, there are no specific guidelines regarding the number and types of products that should be included in these protocols. MTPs may vary from hospital to hospital.

METHODS:
A short, web-based survey was sent to blood bank medical directors at academic institutions to learn details about MTPs.

RESULTS:
A total of 107 survey requests were sent, and 56 were completed (52% response rate). All who responded had an MTP in place. Nearly all (n = 55, 98.2% [95% CI, 90.6%–99.7%]) base their protocol on delivery of fixed amounts and ratios of blood products, with only a minority incorporating any elements of laboratory-directed therapy. The most common target, red blood cell (RBC):plasma ratio, is 1:1 (n = 39, 69.9% [95% CI, 56.7%–80.1%] of respondents). The majority (n = 36, 64.3% [95% CI, 51.2%–75.6%]) provide 6 or more units of red blood cells in the first MTP packet.

CONCLUSIONS:
One-hundred percent of survey respondents had an MTP in place. Despite a lack of published guidelines regarding MTPs, the survey results demonstrated substantial uniformity in numbers of products and target transfusion ratios.
An “integrated health neighbourhood” framework to optimise the use of EHR data
Authors: Liaw Siaw-Teng , De Lusignan Simon 
Published: October 2016

General practice should become the hub of integrated health neighbourhoods (IHNs), which involves sharing of information to ensure that medical homes are also part of learning organisations that use electronic health record (EHR) data for care, decision making, teaching and learning, quality improvement and research. The IHN is defined as the primary and ambulatory care services in a locality that relates largely to a single hospital-based secondary care service provider and is the logical denominator and unit of comparison for the optimal use of EHR data and health information exchange (HIE) to facilitate integration and coordination of care. Its size may vary based on the geography and requirements of the population, for example between city, suburban and rural areas. The conceptual framework includes context; integration of data, information and knowledge; integration of clinical workflow and practice; and inter-professional integration to ensure coordinated shared care to deliver safe and effective services that are equitable, accessible and culturally respectful. We illustrate how this HIE-supported IHN vision may be achieved with an Australian case study demonstrating the integration of linked pseudonymised records with knowledge- and evidence-based guidelines using semantic web tools and informatics-based methods, researching causal links bewteen data quality and quality of care and the key issues to address. The data presented in this paper form part of the evaluation of the informatics infrastructure - HIE and data repository – for its reliability and utility in supporting the IHN. An IHN can only be created if the necessary health informatics infrastructure is put in place. Integrated care may struggle to be effective without HIE.
When maize is not the first choice: advances in paleodietary studies in the Archaeological Site Río Doncellas (Jujuy, Argentina)
Authors: Killian Galván Violeta A. , Samec Celeste T. , Panarello Héctor O. 
Published: October 2016

In this work we present new values of stable isotopes of carbon (δ13Cco and δ13Cap) and nitrogen (δ15N) measured in a sample of 13 human individuals found in the Río Doncellas Archaeological Site (Late Period or Regional Developments, ca. 1000 AD-1450 AD) located in the Puna of Jujuy, Northwest of Argentina. The skeletal series belong to the collection of Museo E. Casanova, FFyL – UBA and the Instituto Nacional de Antropología y Pensamiento Latinoamericano, being the result of investigations carried out during the decades of 1940 and 1970, respectively. In addition, in this work we present isotopic compositions of food resources (vegetal and fauna) found in the archaeological record as well as gathered in modern farms located in the study area (Abra Pampa, Cochinoca, Jujuy). This information was used for paleodietary inference, allowing us to establish a hierarchy of the resources that were consumed. The results indicate that maize (Zea mays) is less important than other vegetal resources in the diet, which contradicts the expectations generated from the macrobotanical evidence of the site and the cultivated terraces that surround it. On the other hand, camelids seemed to be widely exploited, which is coherent with the current importance of meat production within the region. These results allow us to assert that the growth of cereals did not have a progressive relevance over other resources.
Painting as Critique: Oil Painting as a Site for Social and Political Negotiation in Syria
Authors: Bank Charlotte 
Published: October 2016

Abstract
Oil painting in the European manner was closely linked to questions of modernity in the Arab world and was often intimately connected with discussions pertaining to national independence and social progress. By reference to the work of the early Syrian painter Tawfiq Tarek, this article discusses oil painting in Syria as a site to negotiating questions of modernity and social and political change. As was the case with his peers from other Arab countries, Tarek, despite having received his training in Paris, was not interested in the avant-garde art movements that sought to disrupt artistic traditions, but preferred to remain within established, academic genres. For him, genres such as history painting and even Orientalism served to convey subversive political messages and declare his commitment to progressive and nationalist ideas, thus linking him and his work to notions of “committed” art.
Linguistic landscaping in Tabriz, Iran: a discursive transformation of a bilingual space into a monolingual place
Authors: Mirvahedi Seyed Hadi 
Published: October 2016

AbstractA growing body of research highlights the significance of visual language use in public sphere in discursively transforming geographical spaces into places. This symbolic construction of places plays a paramount role in the vitality of minority languages by increasing the prestige of minority languages and thus redressing the balance between minority and majority groups. The present article explores the symbolic construction of Tabriz, a Northwest metropolis in Iran which is home to nearly two million Azerbaijani-speaking people. Despite the rich bilingualism in Azerbaijani and Farsi in the city, Farsi, the official language of the state, continues casting a shadow over Azerbaijani through various language policy mechanisms. Drawing upon language policy and planning theories coupled with the principles of geosemiotics, the research examines linguistic landscape data collected in three main streets in Tabriz. The analysis demonstrates what types of discourses mediate and are created by language choices on governmental and private signs. Farsi is normalized for both governmental and private signs reflecting and reproducing national ideologies. The absence of Azerbaijani as the native language of the people in the linguistic landscape (LL) of Tabriz is noticeable. In its entirety, the findings suggest that the linguistic landscape is not always a fair representation of the linguistic repertoire of the people living in a geographical space, but rather language choice in the LL is deployed by the state and/or people to portray an image of a place they desire and aspire to.
Multilingualism and social cohesion: insights from South African students (1998, 2010, 2015)
Authors: Coetzee-Van Rooy Susan 
Published: October 2016

AbstractThe relationship between nations (or states), languages and social cohesion have been studied over time. Contexts like Africa and India challenge the conceived Western notion of “one-nation-one-language”. Insights about multilingualism and social cohesion from complex sociolinguistic contexts like South Africa could provide a deeper understanding helpful for promoting social cohesion in emerging “super-diverse” situations across the globe. This article reports on selected data from a longitudinal language repertoire survey conducted over three periods (1998, 2010 and 2015) in the Vaal Triangle region in South Africa. It discusses the views of multilingual urban students (N=1900+) about the relationship between multilingualism and social cohesion. The main findings are that the multilingual African home language participants believe that being multilingual is related to social cohesion, while this is not a prominent finding for Afrikaans home language users (who are mainly bilingual). The data from the South African context indicate the importance of multilingual repertoires as instruments that support the fostering of social cohesion in complex settings. Multilingual repertoires facilitate communication that enhances the building of better relationships and a deeper understanding between people in diverse settings. The implications of the findings for emerging “super-diverse” global societies are discussed.
Adaptive Fuzzy High-Order Super-Twisting Sliding Mode Controller for Uncertain Robotic Manipulator
Authors: Goel Ankur , Swarup Akhilesh 
Published: October 2016

Abstract
This paper presents a novel adaptive fuzzy high-order super-twisting sliding mode controller, based on the modified super-twisting control (STC), to achieve accurate trajectory tracking for a robotic manipulator with unknown structured uncertainties, parametric uncertainties, and time-varying external disturbances. Initially, a non-linear homogeneous sliding manifold is designed to achieve finite-time convergence, better robustness, and good transient characteristics. Afterwards, conventional STC is modified with the new sliding surface that eliminates the limitation of STC application only on relative degree 1 systems. Moreover, two adaptive fuzzy systems are designed to replace the STC signals for handling the chattering problem and overestimating the controller gains. These fuzzy systems are continuously adjusted by two adaptation laws that are deduced from the Lyapunov stability theory. These adaptive laws need only a sliding surface variable as an input and generate the optimal controller gains as an output. The finite-time convergence and stability of the proposed controller is analyzed by the homogeneous Lyapunov stability theory. Finally, to show the efficacy of the proposed method, the controller is simulated on a 2-degree-of-freedom planar robotic manipulator to obtain the accurate trajectory tracking. Simulation results demonstrate the superiority of the proposed control scheme in the presence of structured and unstructured uncertainties.
Mediated Recognition and the Categorial Stance
Authors: Koskinen Heikki J. 
Published: October 2016

AbstractIn this paper, I articulate a systematic model of mediated recognition based on the notion of the categorial stance. Mediated recognition is understood as a trilateral form of recognition, while the categorial stance is conceived as an epistemic position operating with the most general ontological categories and relations. The central thesis argued for is that the categorial stance can be used as a rational resource for conceptually mediated recognition. I begin with tools found in earlier research literature, then characterize the idea of conceptual rationality, consider contexts of mediated recognition, and finally, integrate the categorial stance into the model.
The Prism of Change
Authors: Bruun Hanne 
Published: October 2016

AbstractThis article presents and discusses the communicative behaviour in the continuity texts produced by public service television providers in Denmark in the digital era. Based on a case study of the two main channels, DR and TV 2, the article argues that, after previous trends towards convergence in the way the two providers communicate, the present developments exhibit a divergence. Three major differences are found in the efforts to (1) hold on to and ‘herd’ the viewers within the scope of products and platforms, (2) strengthen the provider–viewer relationship, and (3) stand out with a distinctive set of institutional values. The findings are interpreted as a consequence of the challenges and opportunities facing the providers in terms of funding and in terms of meeting public service obligations, in a situation of tension between a traditional linear model of broadcasting and an emerging non-linear model.
Epigenomic reprogramming in inorganic arsenic-mediated gene expression patterns during carcinogenesis
Authors: Eckstein Meredith , Eleazer Rebekah , Rea Matthew , Fondufe-Mittendorf Yvonne 
Published: October 2016

Abstract
Arsenic is a ubiquitous metalloid that is not mutagenic but is carcinogenic. The mechanism(s) by which arsenic causes cancer remain unknown. To date, several mechanisms have been proposed, including the arsenic-induced generation of reactive oxygen species (ROS). However, it is also becoming evident that inorganic arsenic (iAs) may exert its carcinogenic effects by changing the epigenome, and thereby modifying chromatin structure and dynamics. These epigenetic changes alter the accessibility of gene regulatory factors to DNA, resulting in specific changes in gene expression both at the levels of transcription initiation and gene splicing. In this review, we discuss recent literature reports describing epigenetic changes induced by iAs exposure and the possible epigenetic mechanisms underlying these changes.
Investigation of mechanical performances of composite bolted joints with local reinforcements
Authors: Zhang Jifeng , Xie Qiang , Xie Yonggang , Zhou Limin , Wang Zhenqing 
Published: October 2016

Abstract
Four different local reinforcement schemes used in composite bolted joints were studied. In numerical study, a set of 3-D failure criteria was used and the progressive failure analysis was implemented via user-defined subroutine vectorized user-material (VUMAT), which was programmed by the commercial finite element (FE) software ABAQUS. In the experiment, test specimens were manufactured with different local reinforcement schemes, and the mechanical performances of these specimens were tested under tensile loads. Failure modes of these specimens were observed and mechanical performances of test specimens with local reinforcement were studied. It was found that the numerical results agreed well with the experiment. It was also found that local reinforcement schemes influenced the mechanical performances of bolted joints obviously and that the tensile strength of composite bolted joints could be improved significantly by burying laminate slices.
Leaves of Cordia boissieri A. DC. as a potential source of bioactive secondary metabolites for protection against metabolic syndrome-induced in rats
Authors: Owis Asmaa I. , Abo-youssef Amira M. , Osman Ahmed H. 
Published: October 2016

Abstract

Cordia boissieri A. DC. (Boraginaceae) is traditionally used as an herbal remedy for diabetes by Hispanic women in Southwestern USA. A recent investigation showed the significant protective effect of ethyl acetate extract against metabolic syndrome (MS). However, the corresponding active principles responsible for this effect and relations between their structure and biological actions remain unclear. Thus, ethyl acetate extract was subjected to column chromatography, which yielded seven compounds identified on the basis of spectroscopic data as rutin, hesperidin, kaempferol-3-O-β-d-glucopyranoside, rosmarinic acid, β-sitosterol-3-O-β-d-glucopyranoside, quercetin, and kaempferol. The isolated compounds (5 mg/kg/day) were tested in a fructose enriched-diet rat model using metformin as a standard drug. Blood samples were withdrawn for estimation of MS-associated biomarkers and liver samples were subjected to histopathological and immunohistochemical examination. The isolated compounds impaired most of the changes associated with MS as evidenced by improved insulin sensitivity, glucose tolerance, kidney function, lipid profiles and reduced oxidative stress and inflammation by different degrees. It is worth noting that quercetin and kaempferol showed the most potent effect. Structure-activity relationship study revealed that the presence of 2,3-double bond in ring C and ortho-hydroxylation in ring B increases the flavonoids activity while glycosylation or methylation decreased this activity.
Acute Effects of Lateral Thigh Foam Rolling on Arterial Tissue Perfusion Determined by Spectral Doppler and Power Doppler Ultrasound
Authors: Hotfiel Thilo , Swoboda Bernd , Krinner Sebastian , Grim Casper , Engelhardt Martin , Uder Michael , Heiss Rafael U. 
Published: October 2016

Abstract
Hotfiel, T, Swoboda, B, Krinner, S, Grim, C, Engelhardt, M, Uder, M, and Heiss, R. Acute effects of lateral thigh foam rolling on arterial tissue perfusion determined by spectral Doppler and power Doppler ultrasound. J Strength Cond Res 31(4): 893–900, 2017—Foam rolling has been developed as a popular intervention in training and rehabilitation. However, evidence on its effects on the cellular and physiological level is lacking. The aim of this study was to assess the effect of foam rolling on arterial blood flow of the lateral thigh. Twenty-one healthy participants (age, 25 ± 2 years; height, 177 ± 9 cm; body weight, 74 ± 9 kg) were recruited from the medical and sports faculty. Arterial tissue perfusion was determined by spectral Doppler and power Doppler ultrasound, represented as peak flow (Vmax), time average velocity maximum (TAMx), time average velocity mean (TAMn), and resistive index (RI), and with semiquantitative grading that was assessed by 4 blindfolded investigators. Measurement values were assessed under resting conditions and twice after foam rolling exercises of the lateral thigh (0 and 30 minutes after intervention). The trochanteric region, mid portion, and distal tibial insertion of the lateral thigh were representative for data analysis. Arterial blood flow of the lateral thigh increased significantly after foam rolling exercises compared with baseline (p ≤ 0.05). We detected a relative increase in Vmax of 73.6% (0 minutes) and 52.7% (30 minutes) (p < 0.001), in TAMx of 53.2% (p < 0.001) and 38.3% (p = 0.002), and in TAMn of 84.4% (p < 0.001) and 68.2% (p < 0.001). Semiquantitative power Doppler scores at all portions revealed increased average grading of 1.96 after intervention and 2.04 after 30 minutes compared with 0.75 at baseline. Our results may contribute to the understanding of local physiological reactions to self-myofascial release.