bluuebunny/crossref_metadata_2025_split huggingface dataset:
The oneirogen hypothesis: modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms
Authors: Bredenberg Colin , Normandin Fabrice , Richards Blake , Lajoie Guillaume 
Published: September 2024

AbstractClassical psychedelics induce complex visual hallucinations in humans, generating percepts that are co-herent at a low level, but which have surreal, dream-like qualities at a high level. While there are many hypotheses as to how classical psychedelics could induce these effects, there are no concrete mechanistic models that capture the variety of observed effects in humans, while remaining consistent with the known pharmacological effects of classical psychedelics on neural circuits. In this work, we propose the “oneirogen hypothesis”, which posits that the perceptual effects of classical psychedelics are a result of their pharmacological actions inducing neural activity states that truly are more similar to dream-like states. We simulate classical psychedelics’ effects via manipulating neural network models trained on perceptual tasks with the Wake-Sleep algorithm. This established machine learning algorithm leverages two activity phases, a perceptual phase (wake) where sensory inputs are encoded, and a generative phase (dream) where the network internally generates activity consistent with stimulus-evoked responses. We simulate the action of psychedelics by partially shifting the model to the ‘Sleep’ state, which entails a greater influence of top-down connections, in line with the impact of psychedelics on apical dendrites. The effects resulting from this manipulation capture a number of experimentally observed phenomena including the emergence of hallucinations, increases in stimulus-conditioned variability, and large increases in synaptic plasticity. We further provide a number of testable predictions which could be used to validate or invalidate our oneirogen hypothesis.
Zebrafish glial-vascular interactions progressively expand over the course of brain development
Authors: Gall Lewis G. , Stains Courtney M. , Freitas-Andrade Moises , Jia Bill Z. , Patel Nishi , Megason Sean G. , Lacoste Baptiste , O’Brown Natasha M. 
Published: September 2024

AbstractGlial-vascular interactions are critical for the formation and maintenance of brain blood vessels and the blood-brain barrier (BBB) in mammals, but their role in zebrafish is not well understood. Our previous work has detailed the timeline of BBB functional maturation in zebrafish, revealing a conserved mechanism of BBB induction through the suppression of endothelial transcytosis. Yet, as opposed to extensive research on glial-vascular interactions in rodents, such interactions remain largely overlooked in the zebrafish model system. Here, we focus on glial-vascular development in the zebrafish brain, leveraging three glial gene promoters:gfap(glial fibrillary acidic protein),glast(an astrocyte-specific glutamate transporter), andglastini(a new, shortened, equally effective version of the Glast promoter). Using these glial promoters, sparse labeling revealed fewer glial-vascular interactions during early larval stages, with both glial coverage and contact area increasing as the zebrafish brain matured. We then generated stable transgenic lines for both the Glast and Glastini promoters and observed similar increases in glial coverage during larval development, starting at ∼30% coverage at 3 days post-fertilization (dpf) and peaking at ∼60% at 10 dpf. Ultrastructural assessment of glial-vascular interactions using electron microscopy (EM) confirmed a progressive increase in glial coverage over larval development, with maximal coverage reaching ∼70% in adult zebrafish, significantly lower than the nearly 100% coverage observed in mammals. Finally, immunogold-EM labeling confirmed that cells identified as glia in aforementioned morphological analyses were indeed Glast-positive. Taken together, our results identify the temporal profile of glial-vascular maturation in the zebrafish brain.
Comparative tissue-specific transcriptomics reveal the genetic bases underlying evolutionary convergence of seed shattering in two independently evolved weedy rice lineages
Authors: Li Xiang , Caicedo Ana L. 
Published: September 2024

SummaryThe repeated evolution of high seed shattering during multiple independent de-domestications of cultivated Asian rice (Oryza sativa) into weedy rice is a prime example of convergent evolution. Weedy rice populations converge in histological features of the abscission zone (AZ), a crucial structure for seed abscission, while ancestral cultivated rice populations exhibit varied AZ morphology and levels of shattering. However, the genetic bases of these phenotypic patterns remain unclear. We examined the expression profiles of the AZ region and its surrounding tissues at three developmental stages in two low-shattering cultivars ofausandtemperate japonicadomesticated varieties and in two genotypes of their derived high-shattering weed groups, Blackhull Awned (BHA) and Spanish Weedy Rice (SWR), respectively. Consistent with the greater alteration of AZ morphology during the de-domestication of SWR than BHA, fewer genes exhibited a comparable AZ-region exclusive expression pattern between weed and crop in thejaponicalineage than inauslineage. Transcription factors related to the repression of lignin and secondary cell deposition, such as,OsWRKY102andOsXND-1-like, along with certain known shattering genes involved in AZ formation, likely played a role in maintaining AZ region identity in both lineages. Meanwhile, most genes exhibiting AZ-region exclusive expression patterns do not overlap between the two lineages and the genes exhibiting differential expression in the AZ region between weed and crop across the two lineages are enriched for different gene ontology terms. Our findings suggest genetic flexibility in shaping AZ morphology, while genetic constraints on AZ identity determination in these two lineages.Significance statementExploring the extent of genetic convergence that underlies the morphological convergence - specifically, the recurrent evolution of complete abscission zones in independently evolved weedy rice populations originating from different cultivated rice populations with varying degrees of disrupted abscission zones - can improve our understanding not only of the genetic mechanisms behind convergent evolution, but also of the genetics underlying the agriculturally importance trait of seed shattering.
Ancient environmental DNA indicates limited human impact on marine biodiversity in pre-industrial Iceland
Authors: Holman Luke E. , Arfaoui Emilia M. R. , Pedersen Lene Bruhn , Farnsworth Wesley R , Ascough Phillipa , Butler Paul , Guðmundsdóttir Esther R. , Reynolds David J. , Trofimova Tamara , Wilkin Jack T. R. , Carøe Christian , Frøslev Tobias Guldberg , Harrison Ramona , Gopalakrishnan Shyam , Pedersen Mikkel Winther , Scourse James , Bohmann Kristine 
Published: September 2024

AbstractHuman activities are affecting marine biodiversity globally by accelerating extinction rates, altering ecosystem conditions, and changing community structures. These changes can only be understood through establishing the ecosystem state prior to significant anthropogenic impact, and by disentangling the anthropogenic effect from natural climatic changes. Here, we reconstruct marine biodiversity in Iceland across three millennia (1315 BCE-1785 CE), encompassing periods of climatic fluctuation and human settlement, to explore the comparative effect of natural and anthropogenic forces on marine biodiversity. We performed 18S metabarcoding of ancient environmental DNA from two sediment cores collected from northern Icelandic shelf seas, integrating local climatic records, population estimates and zooarchaeological remains from published sources to estimate the influence of climatic and anthropogenic impacts. Against the backdrop of increasing human populations and marine exploitation, we observe no large-scale taxonomic shifts or anthropogenic biodiversity changes across the period. In contrast, we found a positive correlation between herring (Clupea harengus) detection rates and proxy-reconstructed sea surface temperature, suggesting a role for climate in shaping marine biodiversity. Overall, our data suggest that despite impacts on terrestrial ecosystems and the development of a substantial export fishery across the study period, Icelandic society may have had a limited effect on marine biodiversity.
Interaction between histone residue H3K56 and mismatch repair protein MutSβ drives CAG repeat expansion
Authors: Guo Jinzhen , Yang Wei , Li Guo-Min 
Published: September 2024

AbstractDNA repair protein MutSβ promotes CAG•CTG repeat expansions, which cause ∼20 untreatable neurodegenerative disorders including Huntington’s disease (HD). However, how MutSβ is recruited onto chromatin to enable repeat expansion is unknown. Here, we show that H3K56 interacts with MutSβ and brings it to chromatin. The H3K56-MutSβ interaction is regulated by H3K56 acetylation (H3K56ac) conditions, with acetylation inhibiting but deacetylation facilitating MutSβ chromatin recruitment. Blocking the H3K56-MutSβ interaction by either disrupting the MutSβ aromatic packet or increasing the H3K56ac level by removing histone deacetylases stabilizes CAG repeats, while depleting histone acetyltransferase p300/CBP promotes the H3K56-MutSβ interaction and CAG•CTG repeat instability, including expansion of CAG repeats of the huntingtin gene. Therefore, our study suggests a novel mechanism, by which MutSβ induces triplet repeat expansion, and new strategies of blocking the H3K56-MutSβ interaction to prevent HD and other triplet repeat expansion-caused disorders.
Radical Protein Footprinting in Mammalian Whole Blood
Authors: Tobin Lyle , Misra Sandeep K. , Luo Haolin , Jones Lisa M. , Sharp Joshua S. 
Published: September 2024

ABSTRACTHydroxyl Radical Protein Footprinting (HRPF) is a powerful method to probe the solvent-accessible surface area of proteins. It is mostly used to study the higher-order structure of proteins, as well as protein-protein and protein-carbohydrate interactions. Hydroxyl radicals are generated by the photolysis of hydrogen peroxide and these radicals modify the surface amino acids. Bottom-up proteomics is then applied and peptide oxidation is calculated and correlated with solvent accessibility. It is mainly performedin vitro; however, it has been recently used in living systems, including live cells, live nematodes, and 3D cell cultures. Mammalian tissues are still out of reach as they absorb UV strongly, hindering radical generation. Here, we describe the first example of RPF in mammalian stabilized whole blood. Using photoactivation of persulfate with a commercially available FOX Photolysis System modified for sample handling and inline mixing, we demonstrate the first labeling of proteins in whole blood. We demonstrate that the RPF protocol does not alter the blood cell gross morphology outside of a moderate hypertonicity equivalent to sodium chloride exposure prior to labeling. We detail an improved quenching protocol to limit background labeling in persulfate RPF. We describe the labeling of the top ten most abundant proteins in the blood. We demonstrate the equivalence ofex vivolabeling in whole blood with labeling of the same structurein vitrousing hemoglobin as a test system. Overall, these results now open the possibility of performing RPF-based structural proteomics in pre-clinical models and using readily available clinical samples.
The effect of meta-commerce consumption value on consumer satisfaction and continuous usage intention: the moderating roles of meta-verse involvement and consumer competency
Authors: Kim Nayeon , Kim Woo-Hyuk 
Published: September 2024

PurposeThe purpose of this study is to investigate the relationships between Meta-commerce consumption value, consumer satisfaction and continuous usage intention in light of the moderating effects of involvement and consumer competency.Design/methodology/approachA survey for hypothesis testing was conducted targeting 200 domestic consumers in South Korea aged 19 years and above with experience in Meta-commerce. In order to examine the data, we used exploratory factor analysis (EFA), confirmatory factor analysis (CFA) and structural equation modeling using SPSS and AMOS.FindingsThe paper discovered that Meta-commerce consumption value affects consumer satisfaction and continuous usage intention. Specifically, the extrinsic value and the epistemic value of Meta-commerce have a positively significant effect on satisfaction. Additionally, the hedonic value of Meta-commerce has a positively significant effect on continuous usage intention. It also presented the differences in influence between low-involvement/high-involvement groups and low-competency/high-competency groups and examined consumer perceptions in detail.Originality/valueThe paper discovered that Meta-commerce consumption value affects consumer satisfaction and continuous usage intention. Specifically, the extrinsic value and the epistemic value of Meta-commerce have a positively significant effect on satisfaction. Additionally, the hedonic value of Meta-commerce has a positively significant effect on continuous usage intention. It also presented the differences in influence between low-involvement/high-involvement groups and low-competency/high-competency groups and examined consumer perceptions in detail.
Fermentation dynamics, physicochemical and sensory characteristics of Malaysian traditional rice wines
Authors: Koay Meiwei , Fan Hui Yin , Wong Clemente Michael Vui Ling 
Published: September 2024

PurposeMalaysian rice wines (tapai) manufactured in small-scale industries are usually formulated based on personal experiences under minimally controlled conditions for generations, especially in Sabah, one of the East Malaysian states. However, the quality and safety of rice wines were receiving increased attention to ensure better quality control, particularly those produced on an industrial scale. Therefore, this research aims to determine the fermentation dynamics and consumers’ acceptance of Malaysian rice wines produced using different sasad (a local term for starter culture from Sabah).Design/methodology/approachThe physicochemical [total soluble solids (TSS), alcohol content, total titratable acidity (TTA) and pH] and microbiological [total yeast and mould count (TYMC) and total lactic acid bacteria (LAB) count] changes in Malaysian rice wines were determined to better understand the fermentation process for future process optimisation. Additionally, sensory evaluations were conducted to determine the consumers’ preferences for the rice wines.FindingsThe overall fermentation dynamics of rice wines exhibited similar trends with slight variations between the samples, demonstrating the effect of microbial compositions of sasad on the quality of final rice wines. Additionally, consumer acceptance tests showed that rice wines with darker shades of yellow and a stronger alcoholic aroma were preferable.Originality/valueThis is the first research that provides important insights into both the fermentation dynamics and consumers’ acceptance of Malaysian traditional rice wines, enriching the rice wine literature from the academic perspective and contributing to the production of safe and high-quality rice wines.
How has scientific performance of distinguished young scholars in China changed compared to their early careers?
Authors: Niu Lihui , Si Xiangyun , Ma Feicheng 
Published: September 2024

Purpose
This paper aims to conduct a comparative analysis of the scientific performance of distinguished young scholars in China during the pre-award and early stages of their research careers, aiming to provide insights into their growth pattern.

Design/methodology/approach
Spearman correlation was used to analyse the correlation between various academic ages and awarding age of the distinguished young scholars. The Wilcoxon matched pairs test was used to analyse variations in their scientific performance across different research stages.

Findings
The findings showed that: a) early successful research experiences significantly impact their emergence as outstanding scientists. While a low correlation exists between publication ages and awards, perseverance proves crucial for later-stage academic achievements; b) productivity increases before awards, with notable variations between first-author and non-first-authored publications; c) collaboration intensifies before awards, particularly in non-first author roles. However, discipline-specific variations highlight the importance of smaller teams and first-author roles, especially in the early career stage; d) the correlation between collaboration and productivity depends on research roles, emphasizing the evolving nature of collaboration dynamics as scholars progress in their careers.

Originality/value
This study could offer a reference for formulating well-founded talent training programs and reward mechanisms.
Report on culture towards critical rapport: basis for cautious, conscious and careful contemporary cultural studies and literacy
Authors: Servaña Alvin 
Published: September 2024

PurposeThis paper offers a critical exegesis of popular culture and its intersections with the other cultural expressions in the contemporary Philippine scene. As a distinct Reformed-Evangelical critique, the paper hopes to shed light on the areas of popular culture that are often assumed rather than discussed; affirmed but not analysed.Design/methodology/approachAlthough the following exposition is readily and arguably Western by orientation, most especially on the (post)modern mood in the space it belongs, as hegemonised by Anglo-American discourse, most of the concepts that this paper tackles are definitely universal and principled in praxes. The persuasion is that these criticisms will cover even the Filipino sub-/culture and sensibility in its attempt to exegete culture ontologically and contemplate on the phenomenon of popular culture at the very least. In that case, everyone who reads and specialises in cultural hermeneutics is thereby urged to offer a conscious understanding, comprehension and correspondence on the aforementioned particular aspects, albeit not everyone in the masses can readily grasp what this paper intends to build its discourse on. In carrying out this cultural exegetical task, certain markers and indicators will be used as halters, so to defamiliarise one’s attention on matters that may have immediate correspondence to the Filipino culture in its contemporary scene/sense, be it urban, suburban or rural depending on the spatial location of the readers as they interact with this treatise. As a whole, this paper endeavours to mould and uphold one’s glocal consciousness, distinctions, and differentiations in the assessment of culture, popular culture and popular culture in the Philippines vis-a-vis or vs other factors of this shared reality, sub-/culture and literacy and their probable popular culture counterparts elsewhere in the signifying and significant human experiences, challenges and perspectives.FindingsThe paper finds out that without a critico-practical approach to the implications of popular culture, it will be an insidious challenge to anyone who wishes to coexist with it, most especially the subcultural expressions of certain communities.Originality/valueThe paper possesses novelty in its being an intersection of cultural studies, criticism, theology and philosophy as basis for interpretation of certain socio-cultural phenomena in the contemporary urban space.
Memory response in quasi-static thermoelastic stress in a rod due to distributed time-dependent heat sources
Authors: Balwir Apeksha , Kamdi Dilip , Varghese Vinod 
Published: September 2024

PurposeTo find the quasi-static thermoelastic stress and displacement, the proposed model looks at how the microstructures interact with each other and how the temperature changes inside a rod. It uses the fractional-order dual-phase-lag (FODPL) theory to derive analytical solutions for one-dimensional problems in nonsimple media within the MDD framework. The dimensionless equations are used to analyze a finite rod experiencing the heat sources continuously distributed over a finite portion of the rod which vary with time according to the ramp-type function with other sectional heat supplies kept at zero temperature. The study introduces a technique using integral transforms for exact solutions in the Laplace transform domain for different kernel functions.Design/methodology/approachA novel mathematical model incorporating dual-phase-lags, two-temperatures and Riesz space-fractional operators via memory-dependent derivatives has been established to analyze the effects of thermal stress and displacement in a finite rod. The model takes into account the continuous distribution of heat sources over a finite portion of the rod and their time variation according to the ramp-type function. It incorporates the finite Riesz fractional derivative in two-temperature thermoelasticity with dual-phase-lags via memory effect, and its solution is obtained using Laplace transform with respect to time and sine-Fourier transform with respect to spatial coordinates defined over finite domains.FindingsIn memory-dependent derivatives, thermal field variables are strongly influenced by the phase-lag heat flux and temperature gradient. The non-Fourier effects of memory-dependent derivatives substantially impact the distribution and history of the thermal field response, and energy dissipation may result in a reduction in temperature without heat transfer. The temperature, displacement and stress profile exhibit a reduced magnitude with the MDD effect compared to when the memory effect is absent (without MDD). To advance future research, a new categorization system for materials based on memory-dependent derivative parameters, in accordance with the principles of two-temperature thermoelasticity theory, must be constructed.Research limitations/implicationsThe one-dimensional assumption introduces limitations. For example, local heating of a one-dimensional plate will not extend radially, and heating one side will not heat the surrounding sides. Furthermore, while estimating heat transfer, object shape limits may apply.Originality/valueThis paper aims to revise the classical Fourier law of heat conduction and develop analytical solutions for one-dimensional problems using fractional-order dual-phase-lag (FODPL) theory in nonsimple media in the context of MDD.