bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Exact Algorithm for the Fixed Charge Transportation Problem Based on Matching Source and Sink Patterns
Authors: Mingozzi Aristide , Roberti Roberto 
Published: April 2017

This paper describes an exact algorithm for the fixed charge transportation problem based on a new integer programming formulation that involves two sets of variables representing flow patterns from sources to sinks and from sinks to sources. The formulation states to select a pattern for each source and each sink and to match the corresponding flows. The linear relaxation of this new formulation is enforced by adding a pseudo-polynomial number of equations that are shown to contain, as special cases, different valid inequalities recently proposed for the problem. The resulting lower bound dominates the lower bounds proposed in the literature. Such a lower bound is embedded into an exact branch-and-cut-and-price algorithm. Computational results on benchmark instances show that the proposed algorithm is several times faster than the state-of-the-art exact methods and could solve all open instances. New harder instances with up to 120 sources and 120 sinks were solved to optimality. The online appendix is available at https://doi.org/10.1287/trsc.2017.0742 .
Autologous Pericardial Patch Repair for Papillary Fibroelastoma on an Aortic Valve Leaflet
Authors: Sakata Tomoki , Nakaya Mitsuru , Otsu Masayoshi , Sunazawa Toru , Wakabayashi Yutaka 
Published: April 2017

A 50-year-old man with no history of cardiovascular disease was referred to our hospital because of an abnormal electrocardiogram. Echocardiograms and computed tomograms revealed a 9-mm mass on the underside of an aortic valve leaflet. We chose surgical treatment, to prevent embolic events. The tumor's appearance and intraoperative frozen section were consistent with myxoma. We resected the tumor and its attachment, including the free margin of the aortic valve leaflet, and repaired the defect with use of a glutaraldehyde-treated autologous pericardial patch. The postoperative histopathologic diagnosis was papillary fibroelastoma. Six months later, echocardiograms showed mild aortic regurgitation and no recurrence of the aortic valve mass.
Papillary fibroelastoma and myxoma can be difficult to distinguish intraoperatively, yet the diagnosis has considerable influence on the surgical strategy, including whether valve-sparing excision is an option. Therefore, it is necessary to at least suspect both entities if the tumor characteristics are unusual. This case is instructive for surgeons and pathologists.
Tumor Blood Vessels and Vasculogenic Mimicry – Current Knowledge and Searching for New Cellular/Molecular Targets of Anti-Angiogenic Therapy
Authors: Knopik-Skrocka Agnieszka , Kręplewska Patrycja , Jarmołowska-Jurczyszyn Donata 
Published: April 2017

Summary
Blood vessel formation in tumor is defined as tumor angiogenesis. So far, the most known its mechanism is sprouting, which means formation of blood vessels from existing ones, as a result of the proliferation and migration of endothelial cells. The main mitogenic factor of these cells is vascular endothelial growth factor VEGF, acting by VEGFR-2 receptors. Recent studies have provided knowledge about the ability of tumors to form vessel-like structures. The phenomenon was called vascular mimicry. Tumor cells show a high plasticity and they can undergo differentiation to the ones with phenotype similar to endothelial cells. Each of the known tumor angiogenesis mechanisms is a result of many different factors and cell cooperation in tumor microenvironment. Tumor ability to the heterogeneous vascularization forces developing of complex, anti-angiogenic therapy directed to different molecular and cellular targets. Therapies, used so far, often lead to drug-induced hypoxia, which increases tumor cell aggressiveness and metastasis.
An analysis and comparison of two German thrust-fencing manuscripts
Authors: Noort Reinier van , Schäfer Jan 
Published: April 2017

Abstract
In this contribution, we will discuss two German fencing manuscripts - Mscr.Dresd.C.13 (SLUB Dresden) and Add MS 17533 (BL London). Both manuscripts present texts on thrust-fencing based on the teachings of Salvator Fabris. The dedication of manuscript C13 was signed by the famous fencing author Johann Georg Pascha. The author of one of the texts contained in the 17533 manuscript is named H.A.V..
A textual analysis has been performed on these two books, and then the contents of the works have been compared. This comparison shows that C13 presents a largely identical text to the main treatises contained in 17533, the most significant difference being certain additions in C13, which Pascha also discusses in his dedication. Based on our analysis, both C13 and 17533 appear to present copies of an original text. We further hypothesize that H.A.V., the author of this original text, was Heinrich von und zum Velde, the fencing master of Johann Joachim Hynitzsch.
The variability of protein structure with respect to the hydrophobic core
Authors: Banach Mateusz , Wiśniowski Zdzisław , Kalinowska Barbara , Konieczny Leszek , Roterman Irena 
Published: April 2017

Abstract
The application of the fuzzy oil drop model to the analysis of protein structure is shown using two proteins. The selection of these two examples is due to their opposite character. Two proteins were selected representing very high order and very high disorder with respect to the organized uni-central hydrophobic core in proteins (one centrally localized concentration of high hydrophobicity). These two cases are to show examples of the large spectrum of variability of local organization of the hydrophobic core in proteins. The importance of the observation presented in this paper is significant with respect to large sets of proteins discussed in separate publications.
Circulating cell-free microRNAs as clinical cancer biomarkers
Authors: Armand-Labit Virginie , Pradines Anne 
Published: April 2017

AbstractMicroRNAs (miRNAs) are non-coding small RNAs that are master regulators of genic expression and consequently of many cellular processes. But their expression is often deregulated in human tumors leading to cancer development. Recently miRNAs were discovered in body fluids (serum, plasma and others) and their levels have often been reported to be altered in patients. Circulating miRNAs became one of the most promising biomarkers in oncology for early diagnosis, prognosis and therapeutic response prediction. Here we describe the origins and roles of miRNAs, and summarize the most recent studies focusing on their usefulness as cancer biomarkers in lung, breast, colon, prostate, ovary cancers and melanoma. Lastly, we describe the main methodologies related to miRNA detection, which should be standardized for their use in clinical practice.
Degradation of dimethyl phthalate esters by a filamentous fungus Aspergillus versicolor isolated from deep-sea sediments
Authors: Wang Jing-Wen , Xu Wei , Zhong Tian-Hua , He Gao-Yang , Luo Zhu-Hua 
Published: April 2017

AbstractDimethyl phthalate esters (DMPEs), which belong to phthalate esters (PAEs), are widely distributed environmental pollutants with endocrine-disrupting toxicity. The present study focused on a filamentous fungus capable of degrading DMPEs isolated from deep-sea sediments of the Indian Ocean at a water depth of 3300 m using an enrichment culture technique. The filamentous fungus was identified as
Nato Fuori Posto: Exploring Placelessness in Dean Serravalle’s “The Buried Tree”
Authors: Agostinelli Gianluca 
Published: April 2017

Abstract
Building on the seminal scholarship of humanistic geographer, Edward Relph, this paper explores the postmodern notion of placelessness in Canadian-Italian literature. The author argues that placelessness can afford bi-cultural writers, and their literary protagonists, a degree of productive peripherality that works to deconstruct and undercut the authoritative dynamic of a culturally dominant place. Working with the concept of placelessness, the author analyzes, critically, “The Buried Tree,” a short story composed by Canadian-Italian author, Dean Serravalle, to suggest that the metaphysical state is not one of precarity and dearth but, rather, one of purposeful resistance to the traditional, often oppressive notions of cultural hybridity. While Serravalle’s text focalizes the strong senses of home and cultural rooting as fundamental markers of ethnic identity, placelessness, a space associated primarily with exclusion, can offer refuge and escape for the protagonost, Michele, who seeks both ethnic dissociation from the familial traditions into which he is born, and detachment from his innate, immigrant history. By exploring Michele’s identity crisis, Serravalle seems to challenge the traditional narrative of lifelong, oppositional pluridimensionality, and posits placelessness as a productive, and perhaps necessary, personal state to establish, rather than to reclaim, one’s cultural roots.
The Intervening Role of Competitiveness on the Relationship Between Sustainability and Tourism Performance: A Research on European Countries
Authors: Özyurt Paşa Mustafa , Kantarcı Kemal 
Published: April 2017

Abstract
Being green and being an economically successful and competitive destination has been the core topic in the sustainable development literature in recent years. The link between sustainability and competitiveness in the market is fairly important to study in the tourism industry in order to support and encourage decision makers and stakeholders in their decisions. In this sense, this study has two aims. First aim is to cluster European countries based on their sustainability scores reported in World Economic Forum’s Global Competitiveness Index. Second aim is to reveal the intervening role of competitiveness on the relationship between sustainability and tourism performance for European countries. We employed a K-means cluster analysis and several multiple regression analyses. Analyses results revealed three clusters for European countries. Another finding postulated that competitiveness of these countries have been influenced by their level of sustainability. Our final finding posits that tourism performance of these countries in terms of tourist arrivals and tourism receipts has been found to be impacted by the level of tourism competitiveness.
Effects of Remittances on Rural and Regional Poverty in the Republic of Serbia
Authors: Peković Drinka 
Published: April 2017

Abstract
This paper examines an effect the remittances have on poverty alleviation of rural households and regions in which exist a large number of the emigrants among population. Remittances represent a significant part of additional income of the household mostly used for consumption and improvement of the living standard. Using data from Living Standards Measurement Survey 2007, an impact of the remittances on the poverty index, depth of poverty and poverty severity in the Republic of Serbia is estimated. Due to limitation of data, counterfactual household consumption is estimated in conditions of remittances absence, where the last is treated as exogenous transfer of money. The results show that remittances have a larger impact to poverty of rural households, especially to the depth and severity of poverty. According to the regions, remittances have the largest impact to the poverty level in East Serbia, but these effects on poverty depth and severity are not statistically significant. The smallest changes in the depth and severity of poverty are noticed in Sumadija.
Integrated AHP-TOPSIS Method for the Assessment of Health Management Information Systems Efficiency
Authors: Rađenović Žarko , Veselinović Ivana 
Published: April 2017

Abstract
The aim of this paper is to analyse and estimate the efficiency of health information systems in the provision of health care services. The evaluation of health information systems is conducted in the case of three most widely used softwares in the electronic health care. This evaluation is based on multi-criteria analysis of the health information systems efficiency using the AHP-TOPSIS method. This method, based on common attributes and their respective values for all three software solutions, individually determines the best rated software solution. Top rated software solution of electronic health care is not necessarily the best for the implementation and development, given the fact that each health care organisation has its own characteristics. Functional and evolutionary-minded hardware and software applicative infrastructure contributes to the consistency of electronic health concept that all system users provides a comfortable software solutions, which ultimately leads to the timely and quick medical services in real time.
Are You Too Successful to Digitalize? How to Fight Innovation Blindness
Authors: Neus Andreas , Buder Fabian , Galdino Fernando 
Published: April 2017

Abstract
Digital transformation requires a digital mindset and new approaches to dealing with both decision risk and decision speed. Well-entrenched companies seem to hold all the assets needed to adapt and keep succeeding, but sometimes they don’t seem to adequately react to a disruptive threat; instead, they show symptoms of innovation blindness. They might overestimate their digital skills or their learning occurs too slowly and resources are being wasted. Deep expertise that used to be an asset turns into a liability because companies are stuck in old mental models.
A few things can be done proactively to avoid major pitfalls in the digitalization of a business. Facts that are taken for granted need to be challenged and checked against reality to identify strategic failure in time. Whenever somebody assumes that something is “surely” true, a company’s alarm bells should go off. Moreover, top management needs to check if their digital projects not only scratch the surface but that they grasp the essence of what makes them successful: creating new added value, dramatically increasing speed and ease of use, reducing complexity, and lowering costs substantially. Also, a new approach to innovation, such as design thinking, encourages rapid prototyping and a fast-failure culture.
Mathematical Modeling of Liquid Slag Layer Fluctuation and Slag Droplets Entrainment in a Continuous Casting Mold Based on VOF-LES Method
Authors: Zhao Peng , Li Qiang , Kuang Shi Bo , Zou Zongshu 
Published: April 2017

Abstract
The slag behaviors, directly relating with the qualities of the final cast products, are influenced by the transient surface flow of liquid steel in a continuous casting mold. A one-half scale model is used to investigate the slag behaviors and their droplets entrainment. The model based on Volume of Fluid (VOF) multiphase coupled with Large Eddy Simulation (LES) is established to further illuminate the phenomena of the liquid oil layer fluctuation, the slag “eye” regions, and the slag entrainment observed in water experiment. The effects of casting speeds on the slag behaviors and their entrained droplets are investigated. The results show that the fluctuation of the oil layer is influenced by the transient flow. The calculations for the oil layer profile, the accumulation, and protrusions of oil layer are consistent with the water experiment. The asymmetry of the slag “eye” regions is also influenced by the asymmetry of free surface and transient turbulent flow. The “eye” regions near the narrow wall show distinct asymmetric change at different casting speeds. At a lower casting speed, the slag “eye” regions change irregularly and display the alternate process of open and collapse at the two sides of the narrow walls of the model. While at a relative higher casting speed, the slag layer gathers toward the nozzle, and the slag “eye” regions gradually grow and always open. The simulation model can reveal that the mechanism of the slag entrainment includes two main modes: the cutting or dragging mode and shear layer instability. The average diameter and amount of the entrained droplets are calculated through the UDF codes of ANSYS FLUENT software, and the size distribution of the entrained droplets is also counted. When the casting speed is lower, the dominant diameters of the entrained droplets range between 2 and 3 mm. With casting speed increase, the distribution of the droplets becomes wider, and there is a gradually increase in the percentage of larger droplets with a size of 4–6 mm.
Creativity in Translator Training: Between the Possible, the Improbable and the (Apparently) Impossible
Authors: Hewson Lance 
Published: April 2017

Abstract
The first part of this paper looks at how creativity has been explored in writings in the field of translation studies. It examines the stages in creative translation and investigates the creative process. The second part of the paper looks at how creativity can be exploited in the translation class by concentrating in particular on the liberating role of intralingual and interlingual paraphrase, while considering the various constraints operating on the selection of the optimal target text.
Intermodal Corpora and the Translation Classroom: What can Translation Trainers and Trainees Learn from Interpreting?
Authors: Ferraresi Adriano 
Published: April 2017

Abstract
This contribution focuses on didactic applications of intermodal corpora, i.e. corpora featuring interpreted and translated language. It relies on EPTIC, a multipletranslation and intermodal parallel corpus containing EU Parliament plenary speeches in Italian and English. The peculiar nature of EPTIC allows the investigation of a set of translational alternatives which are distinguished by modality- and task-based constraints (written vs. oral, translated vs. interpreted). To exemplify the potential of such corpus evidence, teaching activities focusing on collocations are proposed that encourage students to reflect on the decision-making processes involved in the slower-paced, reflective task of translation, vs. the faster, more automatic one of interpreting. A method is also described that can facilitate the selection of relevant didactic examples.
A Knot Polynomial Invariant for Analysis of Topology of RNA Stems and Protein Disulfide Bonds
Authors: Tian Wei , Lei Xue , Kauffman Louis H. , Liang Jie 
Published: April 2017

Abstract Knot polynomials have been used to detect and classify knots in biomolecules. Computation of knot polynomials in DNA and protein molecules have revealed the existence of knotted structures, and provided important insight into their topological structures. However, conventional knot polynomials are not well suited to study RNA molecules, as RNA structures are determined by stem regions which are not taken into account in conventional knot polynomials. In this study, we develop a new class of knot polynomials specifically designed to study RNA molecules, which considers stem regions. We demonstrate that our knot polynomials have direct structural relation with RNA molecules, and can be used to classify the topology of RNA secondary structures. Furthermore, we point out that these knot polynomials can be used to model the topological effects of disulfide bonds in protein molecules.
Simulation and Optimization of Throttle Flowmeter with Inner-Outer Tube Element
Authors: Meng Jiang , Liu Zhipeng , An Kun , Yuan Meini 
Published: April 2017

Abstract
In order to solve the dilemma between the smaller pressure loss and the larger flow measurement signal in traditional throttle flowmeters, a throttle structure with the inner-outer tube was designed and analyzed. The mathematical relationship model deduced from hydrodynamics showed there were three major parameters to determine the designed throttle structure. Furthermore, the optimal results were achieved by combining orthogonal test design and computational fluid dynamics by taking the ratio of differential pressure of inner-outer tube divided by that of anterior-posterior tube as the optimization goal. Finally, the simulation results with the best level parameters showed that the differential pressure of the anterior-posterior throttle could remain not only the smaller value among other parameters with the same structure of inner-outer tube. On the other hand, it was about one order magnitude less than differential pressure of V-cone flowmeter in the similar installation conditions with the flow velocity varying from 0.5 to 3.0 m/s. The designed inner-outer tube flowmeter can not only save manufacture costs, but also avoid the large sensitivity of pressure sensors, which may lead to a broader application in chemical and petrochemical enterprises.
Interactions and Optimizations Analysis between Stiffness and Workspace of 3-UPU Robotic Mechanism
Authors: Zhang Dan , Wei Bin 
Published: April 2017

AbstractThe interactions between stiffness and workspace performances are studied. The stiffness in x, y and z directions as well as the workspace of a 3-UPU mechanism are studied and optimized. The stiffness of the robotic system in every single moveable direction is measured and analyzed, and it is observed that in the case where one tries to make the x and y translational stiffness larger, the z directional stiffness will be reduced, i.e. the x and y translational stiffness contradicts with the one in z direction. Subsequently, the objective functions for the summation of the x and y translational stiffness and z directional stiffness are established and they are being optimized simultaneously. However, we later found that these two objectives are not in the same scale; a normalization of the objectives is thus taken into consideration. Meanwhile, the robotic system’s workspace is studied and optimized. Through comparing the stiffness landscape and the workspace volume landscape, it is also observed that the z translational stiffness shows the same changing tendency with the workspace volume’s changing tendency while the x and y translational stiffness shows the opposite changing tendency compared to the workspace volume’s. Via employing the Pareto front theory and differential evolution, the summation of the x and y translational stiffness and the volume of the workspace are being simultaneously optimized. Finally, the mechanism is employed to synthesize an exercise-walking machine for stroke patients.
Language policies in play: Learning ecologies in multilingual preschool interactions among peers and teachers
Authors: Cekaite Asta , Evaldsson Ann-Carita 
Published: April 2017

AbstractIn this study we argue that a focus on language learning ecologies, that is, situations for participation in various communicative practices, can shed light on the intricate processes through which minority children develop or are constrained from acquiring cultural and linguistic competencies (here, of a majority language). The analysis draws on a language socialization approach to examine the micro-level contexts of an immigrant child’s preschool interactions with peers and teachers, and the interplay between these and macro-level language and educational policies. It was found that, in contrast to institutional and curricular policy aspirations concerning the positive potentials of children’s play as a site associated with core learning affordances, the language learning ecology created in the multilingual peer group interactions was limited. Social relations in the peer group, the novice’s marginal social position, and the child’s rudimentary knowledge of the lingua franca, Swedish, precluded her from gaining access to shared peer play activities. The current study thus corroborates prior research showing that peer interactions in second language settings may pose a challenge to children who have not already achieved some competence in the majority language and that more support and interactions with the teachers can be useful.