bluuebunny/crossref_metadata_2025_split huggingface dataset:
POESIA PAN-AMAZÔNICA: RESISTÊNCIA E VALORIZAÇÃO DA CULTURA LOCAL NA ESCOLA ESTADUAL SÃO JOSÉ, TEFÉ-AMAZONAS.
Authors: Bastos da fonseca Thaila 
Published: October 2024

O presente trabalho aplicado pelos bolsistas de iniciação à docência do PIBID/Letras-Língua Portuguesa/2018 do CEST/UEA, aos estudantes do ensino fundamental, turno vespertino da Escola Estadual São José, localizada em Tefé-Amazonas, versa sobre o uso da Poesia Pan-Amazônica no contexto escolar como tentativa de resistência e valorização da cultura local. Neste sentido, a proposta é justificável, pois a poesia é uma arte capaz de desenvolver no sujeito a criatividade, a sensibilidade poética e o potencial artístico. A problemática emergiu devido ao fato de que os estudantes não conheciam e nem tinham acesso às obras poéticas representativas de autores amazonenses. Nesta perspectiva, o poema tem a finalidade de produzir determinado efeito na apreensão do sujeito-leitor e a poesia caracteriza-se como a arte literária, capaz de desenvolver no aluno-sujeito, a criticidade e o potencial artístico do mesmo. Desse modo, através do uso de poemas, oferece-se aos alunos e aos docentes, a possibilidade de construção de suas identidades e de valorização de suas culturas. Utilizamos como suporte para a discussão os autores: Mello (1992), Telles (2010), Moriz (2012), Loureiro (2015), entre outros. No fazer metodológico, introduzimos o respectivo trabalho, apresentando o gênero textual poema e sua respectiva estrutura. Após, realizamos estudos de textos poéticos de poetas representativos da literatura amazônica, além de uma oficina de produção de poemas inspirados no imaginário e universo Amazônico, para assim, contribuir na valoração da cultura e poética pan-Amazônica. Como principais resultados, inferimos que os estudantes, além de conhecer profundamente o pensamento e devaneios do universo dos povos da Amazônia, desenvolveram o potencial artístico e criativo dos mesmos, através da produção autêntica de suas poesias, as quais contribuíram para a valorização da arte poética pan-amazônica no contexto escolar do município de Tefé.
TORNAR-SE NEGRO COM A COR DA TERNURA, DE GENI GUIMARÃES: REFLEXÕES PARA UM LETRAMENTO LITERÁRIO ANTIRRACISTA
Authors: De Morais e Silva Karina , Lourenço  Valéria Correia 
Published: October 2024

Partindo da narrativa autobiográfica da escritora Geni Guimarães em sua obra A cor da ternura (2018), nosso trabalho busca apresentar como o referido texto pode contribuir para a construção de pedagogias antirracistas em dois vieses: primeiramente, promovendo reflexões sobre as relações interétnicas na escola, e, em seguida, como material literário para práticas de letramento literário. Ao protagonizar personagens negras, a escrita literária de Geni Guimarães desvela a intimidade dos impactos psicossociais do racismo em suas trajetórias por meio de uma trama que vai da dolorosa assimilação das conflitualidades raciais por parte das crianças negras à sua autoafirmação identitária. Nesse sentido, nosso estudo pretende explorar a potencialidade literária da autora para a educação das relações étnico-raciais, considerando essa proposta pedagógica em sua filiação a um amplo programa de políticas antirracistas, as quais têm na lei 11.645/08, que trata da obrigatoriedade do estudo de história e cultura afro-brasileira e indígena nos estabelecimentos de ensino públicos e privados, um marco legal histórico. Participam da fundamentação de nossas reflexões, no toca à relação entre a escola, a literatura e as práticas de enfrentamento ao racismo, a conceituação de letramento literário de Rildo Cosson (2009) e a pesquisa sobre as relações interétnicas na educação escolar de Cavallero (2012); para a análise do texto literário estudado, dialogamos com as pesquisas psicanalíticas sobre os impactos psíquicos do racismo de Grada Kilomba (2019) e de Neusa Santos Souza (1983).
Analisis Pengukuran Produktivitas Dengan Menggunakan Metode American Productvity Center (APC) Di UD. Harum Manis Cap Rajawali Kota Tebing Tinggi
Authors: Wirda Novarika AK  , Abdurrozzaq Hasibuan  , Syafitri Ilmi 
Published: October 2024

Penelitian ini dilakukan di UD. Harum Manis Cap Rajawali Kota Tebing Tinggi yang dimana bertujuan untuk mengidentifikasi hasil produktivitas serta untuk memberikan solusi perencanaan dalam peningkatan produktivitas. Metode APC (American Productivity Center) ialah metode untuk mengukur indikator produktivitas, indeks profitabilitas serta perbaikan harga yang memperhitungkan tenaga kerja, bahan baku, energi, modal dan input total terhadap output. Untuk dapat mengetahui sebab akibat permasalahan dan usulan perbaikan masalah penulis menggunakan metode diagram tulang ikan. Berdasarkan hasil penelitian tingkat profitabilitas mengalami naik turun yang tidak konstan yaitu tenaga kerja 5,44%, bahan baku 3,92%, energi 5,46%, modal 11,58%. Hasil analisa dan pembahasan bahwa peningkatan indeks produktivitas dan indeks profitabilitas mengalami peningkatan dibulan Desember yaitu tenaga kerja 1,37%, energi 1,38%, bahan baku 7% modal 8,39%. Dari hasil produktivitas dan profitabilitas faktor yang paling terpengaruh adalah tenaga kerja yang tidak adanya motivasi serta tidak adanya intensif bagi karyawan, faktor material pemborosan bahan baku serta penggunaan yang kurang hati-hati, faktor energi penggunaan yang kurang optimal, faktor modal karena menurunnya pendapatan setiap bulannya.
Analisis Taktik Pertandingan Pencak Silat Kategori Tanding
Authors: Mujahid Hamzah , Subekti Nur 
Published: October 2024

The purpose of this study is to determine the structure of the tactical actions of the pencak silat match in the sparring category as well as the differences based on the match rounds and match results. based on match rounds and match results. The research method used a quantitative approach based on observation-survey on 98 athletes in 48 final matches in three elite level pencak silat championships; National Sports Week, Sea Game, Asian Games. Data collection was through observation of match videos, recording all tactical actions (attack, defense, block).(attack, defense, block) and analyzed using SPSS. Based on the round of the match, there were differences in the actions of attacking and defending sig values < p 0.05 between rounds 1-2 and 1-3, but between rounds 2-3 no difference was found sig value > p 0.05. As for action blocks found no difference in sig value > p 0.05 between rounds 1-2-3. In terms of match results, differences were found with a sig value < p 0.05 in the action of attacking and defending tactics; winners tend to utilize the ability of defense, while non-winners tended to perform attacking actions, while the block actions of winners and non-winners were relatively balanced. non-winners were relatively balanced. The results of the study can be a reference for martial arts coaches and practitioners in organizing tactics training sessions considering changes in action organizing tactics training sessions considering changes in the actions of each round of the match.
Menyama Braya dalam Masyarakat Bali (Perspektif Pendidikan Agama Hindu)
Authors: Sukariawan Putu 
Published: October 2024

Hindu religious education must be taught to become a guide to life that contains many values ​​and norms that will help people live in all things, including their relationship with Sang Hyang Widhi, fellow humans, and their environment. Menyama braya, meaning "brother", is a well-known social value system in Hindu Bali. The concept of equaling braya is a strong foundation in building harmony and implementing respect between religious communities. This research uses a purposive technique, which means that subjects are selected based on research objectives so that informants can provide the necessary information and aim to obtain the necessary and valid information. Data collection in this research refers to the principle that the researcher is the main tool for conducting research which is used objectively and in accordance with the research objectives. Researchers will also collect data through interviews, observation and documentation with appropriate methods, researchers can obtain accurate results and can help in decision making or policy making in the future. In this research, to analyze Menyama Braya in Balinese Society, perfect Hindu Religious Education in its analysis discusses Menyama Braya in the Balinese Community, namely building social harmony and togetherness between fellow citizens in society. There are many religious and cultural values ​​contained in this tradition, especially in relation to Hindu religious education. The function of Hindu religious education is in the menyama braya tradition in the Balinese community which emphasizes building togetherness, developing local culture and traditions, fostering harmony. The Value of Hindu Religious Education in Embracing Braya in the Balinese Community. The value of Hindu religious education plays an important role in preserving and strengthening the concept of Menyama Braya in Balinese society. These religious values ​​emphasize the importance of unlimited brotherhood, helping each other and maintaining balance, respect, and commitment to environmental cleanliness.
Quantitative characterization of retinal features in translated OCTA
Authors: Badhon Rashadul Hasan , Thompson Atalie Carina , Lim Jennifer I. , Leng Theodore , Alam Minhaj Nur 
Published: October 2024

This study explores the feasibility of quantitative Optical Coherence Tomography Angiography (OCTA) features translated from OCT using generative machine learning (ML) for characterizing vascular changes in retina. A generative adversarial network framework was employed alongside a 2D vascular segmentation and a 2D OCTA image translation model, trained on the OCT-500 public dataset and validated with data from the University of Illinois at Chicago (UIC) retina clinic. Datasets are categorized by scanning range (Field of view) and disease status. Validation involved quality and quantitative metrics, comparing translated OCTA (TR-OCTA) with ground truth OCTAs (GT-OCTA) to assess the feasibility for objective disease diagnosis. In our study, TR-OCTAs showed high image quality in both 3 and 6 mm datasets (high-resolution and contrast quality, moderate structural similarity compared to GT-OCTAs). Vascular features like tortuosity and vessel perimeter index exhibits more consistent trends compared to density features which are affected by local vascular distortions. For the validation dataset (UIC), the metrics show similar trend with a slightly decreased performance since the model training was blind on UIC data, to evaluate inference performance. Overall, this study presents a promising solution to the limitations of OCTA adoption in clinical practice by using vascular features from TR-OCTA for disease detection. By making detailed vascular imaging more widely accessible and reducing reliance on expensive OCTA equipment, this research has the potential to significantly enhance the diagnostic process for retinal diseases.
Antioxidant, Anti-Alzheimer’s, anticancer, and cytotoxic properties of peanut oil: in vitro, in silico, and GC-MS analysis
Authors: Djeghim Hanène , Benouchenne Djamila , Mokrani El Hassen , Alsaeedi Huda , Cornu David , Bechelany Mikhael , Barhoum Ahmed 
Published: October 2024

IntroductionPeanut oil is valued for its mild flavor, rich phytochemical content, therapeutic potential, and associated health benefits. This study aims to analyze the chemical composition, antioxidant properties, and anti-Alzheimer’s potential of Algerian peanut oil using both experimental and computational approaches. The goal is to evaluate its suitability for pharmaceutical applications, particularly for its antioxidant, anti-Alzheimer, and anticancer properties.MethodsThe chemical composition of the peanut oil was determined using Gas Chromatography-Mass Spectrometry (GC-MS). Antioxidant activity was assessed through DPPH and CUPRAC assays, while enzyme inhibition was evaluated using butyrylcholinesterase (BChE) inhibition assays. In silico molecular docking studies were conducted to predict interactions between key compounds and BChE. Additionally, physicochemical properties were evaluated using Lipinski’s rule of five, and cytotoxicity was tested against various cancer cell lines, including melanoma (A2058 and SK-MEL-1), non-small cell lung cancer (NCI-H838), and leukemia (H9).ResultsGC-MS identified 20 chemical compounds in the peanut oil, with oleic acid as the predominant compound (41.98%). The antioxidant activity showed an IC50 value of 265.96 ± 14.85 μg/mL in the CUPRAC assay. BChE inhibition was moderate, with 36.47% ± 3.71% enzyme inhibition at 200 μg/mL. Molecular docking studies highlighted 6-methyl octahydro-coumarin with a docking score of −15.86 kJ/mol against BChE, although it was less potent than Galantamine (−23.4 kJ/mol). Physicochemical analysis revealed that oleic acid and palmitic acid exhibit logP values of 5.71 and 5.20, respectively, indicating drug-like potential. Cytotoxicity assessments demonstrated that oleic acid, palmitic acid, and stearic acid were effective against melanoma and lung cancer cells, while oxiraneoctanoic acid, 3-octyl, showed significant activity against leukemia cells.Discussion and conclusionThe results demonstrate that peanut oil possesses notable antioxidant, anti-Alzheimer, and anticancer properties. The high concentration of oleic acid, alongside moderate butyrylcholinesterase (BChE) inhibition and strong cytotoxic effects on various cancer cell lines, highlights its potential as a therapeutic agent. While 6-methyl octahydro-coumarin exhibited favorable docking scores, its lower effectiveness compared to Galantamine suggests that further optimization is required for enhanced efficacy. These findings underscore the potential of peanut oil in pharmaceutical development, with compounds like oleic acid and oxiraneoctanoic acid emerging as promising candidates for continued research and drug development. Peanut oil from Algeria holds significant promise for future applications in antioxidant, neuroprotective, and anticancer therapies.
Elevated postoperative systemic immune-inflammation index associates with acute kidney injury after cardiac surgery: a large-scale cohort study
Authors: Li Yihao , Huang Huansen , Zhou Hongbin 
Published: October 2024

ObjectiveTo investigate whether postoperative systemic immune-inflammation index (SII) is associated with acute kidney injury (AKI) after cardiac surgery.MethodsWe included patients undergoing cardiac surgery from the Medical Information Mart for Intensive Care—Ⅳ database to conduct a retrospective cohort study. The outcomes are AKI, severe AKI, and 30-day mortality after cardiac surgery. Analytical techniques including receiver operating characteristic (ROC) analysis, restricted cubic splines (RCS), and multivariable logistic regression were used to assess the association between SII and outcomes. Sensitivity analyses using inverse probability of treatment weighting (IPTW) and the E-value were conducted to validate the stability of the results.Results3,799 subjects were included in this study. We used ROC to calculate an optimal cutoff value for predicting AKI after cardiac surgery, and subsequently patients were divided into two groups based on the cutoff value (Low SII: ≤ 949 × 109/L; High SII: &gt; 949 × 109/L). ROC showed moderately good performance of SII for predicting AKI, while RCS also indicated a positive association between SII and AKI. The multivariate logistic analysis further affirmed the heightened risk of AKI in patients in the high SII group (OR, 5.33; 95%CI, 4.34–6.53; P &lt; 0.001). Similar associations were observed between SII and severe AKI. Sensitivity and subgroup analyses indicated the robustness of the findings.ConclusionElevated SII was independently associated with a higher risk of AKI in adults undergoing cardiac surgery. The potential causal relationship between postoperative SII and cardiac surgery associated AKI warrants prospective research.
Peripheral biomarkers to assess risk, severity, and prognosis of immune checkpoint inhibitor-associated myocarditis: a retrospective clinical study
Authors: Guan Zhengkun , Yao Tiezhu , Liu Guang , Liu Jing , Guo Ling , Li Zhenli , Ma Jingtao 
Published: October 2024

BackgroundImmune checkpoint inhibitor-associated myocarditis (ICI myocarditis) is an infrequent but potentially fatal immune-related adverse event. This study aimed to identify valuable indicators for risk prediction and evaluation of disease severity and outcomes.MethodsA total of 79 patients with severe or mild ICI myocarditis and 158 controls without post-ICI immune-related adverse events were enrolled in this retrospective study. The clinical application value of a series of simple biomarkers were tested.ResultsHigher levels of the systemic immune-inflammation index (SII), neutrophil-to-eosinophil ratio (NER), aspartate transferase-to-albumin ratio (AAR), and lactic dehydrogenase-to-albumin ratio (LAR) at myocarditis onset were associated with severe disease conditions. In the receiver operating characteristic analysis, biomarkers areas under the curve (AUC) close to or greater than 0.8 were LAR (AUC: 0.810) and AAR (AUC: 0.806). Patients with higher SII, AAR, and LAR also exhibited poorer overall survival. The SII, NER, AAR, and LAR before the last ICI treatment increased relative to baseline in patients with ICI myocarditis, whereas no significant changes in the tested biomarkers were observed in the control group. For SII, AAR, and LAR, high ratios of the biomarker levels before the last ICI to baseline was associated with the incidence of myocarditis.ConclusionsSurveillance of these economical biomarkers during ICI therapy might contribute to the risk prediction of ICI myocarditis, as well as the assessment of disease severity and prognosis.
Long-term Helicobacter pylori infection is associated with an increased risk of carotid plaque formation: a retrospective cohort study
Authors: Chen Yi , Ni Bingqian , Yang Chaoyu , Pan Jingjing , Zhang Jinshun 
Published: October 2024

BackgroundCardiovascular disease significantly impacts human health. The development of carotid plaques elevates the risk of cardiovascular disease, while the influence of Helicobacter pylori (H. pylori) on carotid plaques remains a subject of debate. This study aimed to investigate the association between H. pylori infection and carotid plaque using a cohort study.MethodsThe study included individuals who underwent multiple physical examinations at the Health Examination Center of Taizhou Hospital. The relationship between H. pylori and carotid plaque was explored using multifactorial logistic regression analysis. Participants were categorized into groups based on their H. pylori infection status at the initial and final examinations, comprising persistent infection, persistent negative, new infection, and eradication infection, to analyze variations in carotid plaque prevalence among these groups.ResultsIn both univariate and multifactorial regression analyses, H. pylori was identified as a risk factor for carotid plaque development. Moreover, when compared to the persistent negative group, both the new infection and persistent infection groups showed a notable increase in the risk of carotid plaque. Additionally, individuals in the persistent infection group exhibited higher blood pressure and blood glucose levels than those in the persistent negative group. Likewise, there was a discrepancy in the impact of insulin resistance on carotid plaque between the H. pylori positive and negative groups.ConclusionH. pylori is a risk factor for carotid plaque, with a long-term infection associated with an increased risk of carotid plaque formation. In addition, H. pylori promoting carotid plaque formation may be related to blood pressure, blood glucose, and insulin resistance.
Unequal causality between autoimmune thyroiditis and inflammatory bowel disease: a Mendelian randomization study
Authors: Bai Siyang , Yu Yunfeng , Yang Xinyu , Hu Gang , Wu Jingyi , Tong Keke , Yin Yuman , Deng Juan , Chen Cong , Tan Chuanchuan 
Published: October 2024

ObjectiveThis study aims to analyze the causal relationship between autoimmune thyroiditis (AIT) and inflammatory bowel disease (IBD) using bidirectional Mendelian randomization (MR).MethodsSingle nucleotide polymorphisms were obtained from FinnGen. Exposure-outcome causality was assessed using inverse variance weighted, MR-Egger, and weighted median. MR-Egger intercept, Cochran’s Q, and leave-one-out sensitivity analysis were used to evaluate horizontal pleiotropy, heterogeneity, and robustness, respectively.ResultsForward analysis revealed no significant association between AIT and the risk of ulcerative colitis (UC) (odds ratio [OR] 1.008, 95% confidence interval [CI] 0.986 to 1.03, p = 0.460) or Crohn’s disease (CD) (OR 0.972, 95% CI 0.935 to 1.010, p = 0.143). Reverse analysis showed that UC (OR 0.961, 95% CI 0.783 to 1.180, p = 0.707) was not associated with AIT risk, while CD (OR 2.371, 95% CI 1.526 to 3.683, p &lt; 0.001) was linked to an increased risk of AIT. Intercept analysis and Cochran’s Q test indicated no horizontal pleiotropy or heterogeneity. Sensitivity analysis confirmed the robustness of the MR results.ConclusionThis MR analysis suggests that CD, but not UC, is a risk factor for AIT, whereas AIT is not associated with the risk of IBD. Proactive prevention and treatment of CD can help mitigate the risk of AIT.
Association between the triglyceride–glucose index and left ventricular myocardial work indices in patients with coronary artery disease
Authors: Meng Xuyang , Feng Baoyu , Yang Chenguang , Li Yi , Xia Chenxi , Guo Ying , Wang Xiang , Wang Fang 
Published: October 2024

BackgroundTriglyceride–glucose (TyG) index, as an effective surrogate marker of insulin resistance, has shown predictive value in the risk of heart failure in patients with coronary artery disease (CAD). This study aims to investigate the correlation between TyG index and myocardial work measurements in CAD, and to explore its role in detecting early subclinical cardiac dysfunction.MethodsThis cross-sectional study included 267 patients diagnosed with CAD and excluding left ventricular myocardial dysfunction in Beijing Hospital. Participants were divided into two groups according to the TyG index level, and myocardial work measurements were compared between groups. The correlation was explored between gradually increased TyG index and subclinical myocardial function in CAD patients.ResultsWe observed that TyG index was significantly correlated with the global waste work (GWW), and the value of GWW increased progressively with the elevation of TyG index. After adjusting for the effects of confounding factors, TyG index was still independently associated with GWW.ConclusionAn elevated TyG index was independently correlated with early subclinical myocardial dysfunction in CAD patients. Our study demonstrated that the strict control of TyG index may be conducive to forestall the progression of clinical heart failure in CAD patients.