bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
Authors: Hiemke C. , Bergemann N. , Clement H. , Conca A. , Deckert J. , Domschke K. , Eckermann G. , Egberts K. , Gerlach M. , Greiner C. , Gründer G. , Haen E. , Havemann-Reinecke U. , Hefner G. , Helmer R. , Janssen G. , Jaquenoud E. , Laux G. , Messer T. , Mössner R. , Müller M. , Paulzen M. , Pfuhlmann B. , Riederer P. , Saria A. , Schoppek B. , Schoretsanitis G. , Schwarz M. , Gracia M. , Stegmann B. , Steimer W. , Stingl J. , Uhr M. , Ulrich S. , Unterecker S. , Waschgler R. , Zernig G. , Zurek G. , Baumann P. 
Published: September 2017

AbstractTherapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood to optimize pharmacotherapy. It considers the interindividual variability of pharmacokinetics and thus enables personalized pharmacotherapy. In psychiatry and neurology, patient populations that may particularly benefit from TDM are children and adolescents, pregnant women, elderly patients, individuals with intellectual disabilities, patients with substance abuse disorders, forensic psychiatric patients or patients with known or suspected pharmacokinetic abnormalities. Non-response at therapeutic doses, uncertain drug adherence, suboptimal tolerability, or pharmacokinetic drug-drug interactions are typical indications for TDM. However, the potential benefits of TDM to optimize pharmacotherapy can only be obtained if the method is adequately integrated in the clinical treatment process. To supply treating physicians and laboratories with valid information on TDM, the TDM task force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) issued their first guidelines for TDM in psychiatry in 2004. After an update in 2011, it was time for the next update. Following the new guidelines holds the potential to improve neuropsychopharmacotherapy, accelerate the recovery of many patients, and reduce health care costs.
WAD: Assessment und Management
Authors: Sterling Michele , Smith Ashley 
Published: September 2017

ZusammenfassungWhiplash-Associated Disorders (WAD) umfassen alle klinischen Symptome, unter denen Patienten nach einem Beschleunigungstrauma leiden. Die
Ursachen, die diesen Symptomen zugrunde liegen, sind komplex. Diverse Assessments zu kennen und die Konsequenzen aus deren Ergebnissen zu
ziehen, ist notwendig, um dieser Komplexität gerecht zu werden.
Endovaskuläre Behandlungsoptionen des akuten ischämischen Schlaganfalls
Authors: Langner Sönke 
Published: September 2017

ZusammenfassungDer klinische Nutzen der endovaskulären Schlaganfalltherapie ist in großen randomisierten Studien für den akuten Schlaganfall im vorderen
Kreislauf gezeigt worden. Sie hat sich als Standardtechnik bei Patienten mit großen Gefäßverschlüssen etabliert. Die vorliegende
Übersichtsarbeit erläutert die aktuelle Studienlage, beschreibt das technische Vorgehen bei der mechanischen Thrombektomie und zeigt
typische Bildbefunde postinterventioneller Veränderungen.
Phosphonormalizer: an R package for normalization of MS-based label-free phosphoproteomics
Authors: Saraei Sohrab , Suomi Tomi , Kauko Otto , Elo Laura L 
Published: September 2017

Abstract

Motivation
Global centering-based normalization is a commonly used normalization approach in mass spectrometry-based label-free proteomics. It scales the peptide abundances to have the same median intensities, based on an assumption that the majority of abundances remain the same across the samples. However, especially in phosphoproteomics, this assumption can introduce bias, as the samples are enriched during sample preparation which can mask the underlying biological changes. To address this possible bias, phosphopeptides quantified in both enriched and non-enriched samples can be used to calculate factors that mitigate the bias.

Results
We present an R package phosphonormalizer for normalizing enriched samples in label-free mass spectrometry-based phosphoproteomics.

Availability and implementation
The phosphonormalizer package is freely available under GPL ( &gt; =2) license from Bioconductor (https://bioconductor.org/packages/phosphonormalizer).

Supplementary information
Supplementary data are available at Bioinformatics online.
Prospective Randomized Feasibility Study Assessing the Effect of Cyclic Sacral Neuromodulation on Urinary Urge Incontinence in Women
Authors: Siegel Steven , Kreder Karl , Takacs Elizabeth , McNamara Rachael , Kan Fangyu 
Published: September 2017

Objectives
The aim of this prospective, randomized, multicenter, single-blind, 4 × 4 crossover study was to estimate the effect of 4 InterStim cycling settings (continuous, 16 seconds on/8 seconds off, 10 minutes on/10 minutes off, and 30 minutes on/23.5 hours off) on efficacy, Global Response Assessment, and safety.

Methods
Eligible women implanted for at least 3 months for urgency urinary incontinence (UI) were enrolled, and daily diaries were collected. General linear mixed models were used to estimate the cycling effect on efficacy. Quality of life measured by Global Response Assessment (subjects’ perception of effectiveness) and safety were summarized.

Results
Primary efficacy analysis was based on the first 24 subjects who completed unique randomization sequences. Mean age was 64 years, and mean implant duration was 2.8 years. Results showed no significant cycling (P = 0.3773) or period (P = 0.0800) effect on UI. There was a statistically significant interaction between cycling and period (P = 0.0032). In the first period, subjects on 10 minutes on/10 minutes off had significantly fewer UI episodes compared with subjects on 16 seconds on/8 seconds off (P = 0.0026); this difference was not observed in any other period or sensitivity analyses. No cycling effect was found on urgency or pad usage. When programmed to 10 minutes on/10 minutes off, 54% of subjects felt their incontinence symptoms improved compared with when they entered the study, followed by 42% on 30 minutes on/23.5 hours off, 38% on 16 seconds on/8 seconds off, and 29% on continuous. Safety was similar across cycling settings.

Conclusions
The results suggest that patients with overactive bladder who have been implanted with sacral neuromodulation devices and are receiving substantial benefit may perceive further optimization by switching to cycling settings.
Outcomes of Vaginal Hysterectomy With and Without Perceived Contraindications to Vaginal Surgery
Authors: Schmitt Jennifer J. , Occhino John A. , Weaver Amy L. , McGree Michaela E. , Gebhart John B. 
Published: September 2017

Objective
The aim of this study was to compare outcomes of vaginal hysterectomy between patients with and without the following perceived contraindications to vaginal surgery: uterine weight greater than 280 g, prior cesarean delivery, no vaginal parity, and obesity.

Methods
Retrospective cohort of benign vaginal hysterectomies between 2009 and 2013 was obtained. Outcomes included uterine debulking, transfusion, intraoperative complications, length of stay, and Accordion grade 2+ postoperative complications. For each outcome, the association between the presence of each contraindication and the outcome was evaluated using univariate and multivariate logistic regression models.

Results
Among 692 vaginal hysterectomies, 11% (76/691) had a uterine weight greater than 280 g, 11.3% (78/690) had no vaginal parity, 14.9% (103/690) had a history of cesarean delivery, and 37.7% (248/657) had a body mass index of 30 kg/m2 or greater; 110 (15.9%) had 2 or more contraindications. Uterine debulking occurred in 146 women (21.1%), and both uterine weight greater 280 g (adjusted odds ratio, 39.2; 95% confidence interval, 18.4–83.5) and prior cesarean delivery (adjusted odds ratio, 2.1; 95% confidence interval, 1.2–3.7) were significantly associated with an increased likelihood of uterine debulking after adjusting for age, hematologic disease, and preoperative diagnosis. None of the contraindications were significantly associated with need for a blood transfusion, presence of an intraoperative complication, length of stay greater than 2 days, or presence of an Accordion grade 2+ postoperative complication, which occurred in 2.7%, 2.5%, 14.0%, and 6.9% of all women, respectively.

Conclusions
Vaginal hysterectomy can be safely performed with favorable outcomes, even in women with a uterus greater than 280 g, prior cesarean delivery, no vaginal parity, and obesity. Our findings challenge several perceived contraindications to vaginal hysterectomy.
Digitation to Void: What Is the Significance of This Symptom?
Authors: Ortega Ismael , Subramaniam Nishamini , Friedman Talia , Turel Friyan , Dietz Hans Peter 
Published: September 2017

Objective
Digitation to void is defined as the need to apply manual pressure on the perineum or the vagina to assist with voiding. It has been associated with prolapse; however, there is little objective data concerning this symptom. Our aim was to determine the correlation between digitation to void, symptoms and signs of pelvic organ prolapse (POP), and urodynamic data.

Methods
This was a retrospective study that included a total of 1174 patients seen at a tertiary urogynecological unit. A standardized history was obtained from all patients followed by multichannel urodynamic testing, Pelvic Organ Prolapse Quantification scoring and 3-D/4-D translabial ultrasound. Stored 4-D translabial ultrasound volumes were obtained and analyzed at a later date.

Results
Digitation to void was present in 7% (n = 83) of our population. It is associated with primary symptoms of POP (odds ratio [OR], 25.75; confidence interval [CI], 8.08–82.05), clinically significant POP (OR, 5.62; CI, 2.25–14.02), and POP on ultrasound (OR, 5.39; CI, 2.67–10.88). Cystocele presented the strongest association, clinically (OR, 3.45; CI, 1.98–6.03) and on ultrasound (OR, 4.04; CI, 2.46–6.64). Digitation to void was also associated with symptoms of voiding dysfunction (OR, 6.38 [3.83–10.64]) and slower maximum urine flow rate centile (18.4 vs 24.9, P = 0.017).

Conclusions
Digitation to void is strongly associated with primary symptoms of prolapse and of voiding dysfunction, clinically significant POP, and pelvic organ descent on ultrasound. It is also associated with objective voiding dysfunction. The strongest associations were found with cystocele, both clinically and on imaging.
Temporal proteomic profiling of postnatal human cortical development
Authors: Breen Michael S. , Ozcan Sureyya , Ramsey Jordan M. , Wang Zichen , Ma’ayan Avi , Rustogi Nitin , Gottschalk Michael G. , Webster Maree J. , Weickert Cynthia Shannon , Buxbaum Joseph D. , Bahn Sabine 
Published: September 2017

AbstractHealthy cortical development depends on precise regulation of transcription and translation. However, the dynamics of how proteins are expressed, function and interact across postnatal human cortical development remain poorly understood. We surveyed the proteomic landscape of 69 dorsolateral prefrontal cortex samples across seven stages of postnatal life and integrated these data with paired transcriptome data. We detected 911 proteins by liquid chromatography-mass spectrometry, and 83 were significantly associated with postnatal age (FDRp< 0.05). Network analysis identified three modules of co-regulated proteins correlated with age, including two modules with increasing expression involved in gliogenesis and NADH-metabolism and one neurogenesis-related module with decreasing expression throughout development. Integration with paired transcriptome data revealed that these age-related protein modules overlapped with RNA modules and displayed collinear developmental trajectories. Importantly, RNA expression profiles that are dynamically regulated throughout cortical development display tighter correlations with their respective translated protein expression compared to those RNA profiles that are not. Moreover, the correspondence between RNA and protein expression significantly decreases as a function of cortical aging, especially for genes involved in myelination and cytoskeleton organization. Finally, we used this data resource to elucidate the functional impact of genetic risk loci for intellectual disability, converging on gliogenesis, myelination and ATP-metabolism modules in the proteome and transcriptome. We share all data in an interactive, searchable companion website. Collectively, our findings reveal dynamic aspects of protein regulation and provide new insights into brain development, maturation and disease.
The acceptance of corporate wiki use for knowledge diffusion purposes
Authors: Alqahtani Fayez Hussain 
Published: September 2017

Purpose
Scholars and practitioners alike view knowledge as a crucial organisational asset. Over the past decade, several knowledge management (KM) technologies have emerged, such as wikis. A wiki is a web-based hypertext application that supports a collaborative and conversational approach to KM. While wikis are generally simple to use, their adoption for managing organisational knowledge sometimes meets resistance from employees. The purpose of this paper is to investigate the factors affecting the user acceptance of organisational wikis as a means of knowledge creation and diffusion.

Design/methodology/approach
Building on the existing research on KM and information technology adoption, this study identified the following factors: the relevance of top management support for and complexity of enterprise wikis as well as technical support and knowledge-sharing self-efficacy. A cross-sectional survey was employed to examine the influence of these factors on employees’ acceptance of corporate wikis. Overall, 102 employees participated in the online survey, and the data collected were analysed using the partial least squares method.

Findings
The research model developed demonstrates that top management support, technical support and knowledge-sharing self-efficacy have a positive significant effect on employees’ willingness to use wikis for knowledge-creation purposes within organisations.

Originality/value
The findings of this study contribute to the existing literature on the implementation of wikis as a KM technology by developing a theoretical model explaining employees’ acceptance of this technology. Organisations could use this model to guide and facilitate wiki initiatives.
Non-linear radiative squeezed flow in a rotating frame
Authors: Ahmed Naveed , Khan Umar , Mohyud-Din Syed Tauseef , Jan Saeed Ullah 
Published: September 2017

Purpose
In this current study, the authors aim to analyze non-linear radiative squeezed flow in a rotating frame of viscous fluid.

Design/methodology/approach
The Radioactive nature of the fluid is taken into consideration. The reduced form of equations governing the flow are developed by the implementation of similarity transformations. The coupled system thus obtained is solved by using the homotopy analysis method (HAM).

Findings
Augmentation in velocity and temperature profiles is discussed graphically by varying various involved parameters. The total error of the system is discussed in Table I. The cases of linear radiation and non-linear radiation are also discussed in Tables II and III.

Originality/value
The study presented in this paper is original and it has not been submitted to any other journal for publication purpose. The contents are original and proper references have been provided wherever applicable.
A new meshless approach in simulating free surface flows using continuous MLS shape functions and Voronoi diagram
Authors: Shobeyri Gholamreza , Yourdkhani Mohammad 
Published: September 2017

Purpose
The purpose of this paper is to develop an efficient and accurate mesh-less method to simulate free flows with continuous deformation in boundary positions.

Design/methodology/approach
A two-step pressure projection method in a Lagrangian form is used to solve the governing equations of mass and momentum conservation. In the first step, velocity field is calculated in which incompressibility is not enforced. In the second step, a pressure Poisson equation is applied to satisfy incompressibility conditions. The numerical proposed method is used for spatial discretization of the governing equations. Three benchmark-free surface problems, namely, dam break, solitary wave propagation and evolution of an elliptical bubble with available experimental results and analytical solutions, are used to test the accuracy of the proposed method. The results prove the accuracy of the method in simulating free surface problems.

Findings
The Voronoi diagram instead of kernel function summation can be used to estimate the particle or nodal volume concept in particle-based (mesh-less) methods for function approximation. This idea probably works well especially for highly irregular node distributions.

Originality/value
The continuous moving least squares shape functions are applied for function approximation, and the Voronoi diagram concept is also used to estimate region influence of computational nodal points or particle volumes. Combinations of these two concepts and finite differences formulation for first derivatives gives an accurate numerical model for Laplacian operator in the proposed method.
Does facial width-to-height ratio predict male offender aggression?
Authors: Burris Christopher , Edwards Sherilyn 
Published: September 2017

Purpose
Based on the previously observed link between greater facial width-to-height ratio (fWHR) and interpersonal aggression in men (see Haselhuhn et al., 2015), the purpose of this paper is to test whether fWHR could differentiate among male offenders as a function of the relative aggressiveness of the crime for which they had been convicted.

Design/methodology/approach
fWHR measurements (n=550) were computed based on a large subset of male offenders available on a public domain database. Each offender’s index offense and possible confounding variables such as age, ethnicity, and body mass index were also recorded.

Findings
Multiple analyses yielded no evidence of a relationship between male fWHR and the comparative level of violence of their conviction offense.

Originality/value
Establishing an empirical basis for probable parameters of an unknown offender’s facial structure could have a considerable practical value for criminal profiling purposes. fWHR – at least as it has been most frequently assessed – does not appear to be a facial parameter that is useful for this purpose, however.
Novel Insights into the Inhibitory Effect and Mechanism of Proanthocyanidins from Pyracantha fortuneana Fruit on α‐Glucosidase
Authors: Wei Mankun , Chai Wei‐Ming , Yang Qin , Wang Rui , Peng Yiyuan 
Published: September 2017

AbstractProanthocyanidins were extracted from Pyracantha fortuneana fruit (PFF), and their structures were investigated through 13C nuclear magnetic resonance (13C NMR), high performance liquid chromatography (HPLC) and high resolution mass spectrometry (HRMS). The results showed that these compounds were predominantly constituted of procyanidin with A‐type and B‐type linkage and coexistence of procyanidins glucoside. Spectroscopy methods were used to analyze the inhibitory activity of proanthocyanidins on α‐glucosidase. The results demonstrated that these compounds exhibited excellent inhibitory effect on α‐glucosidase with the IC50 value of 0.15 ± 0.01 μg/mL, and they reversibly inhibited α‐glucosidase in a non‐competitive type. The fluorescence quenching analysis revealed that proanthocyanidins statically quenched the fluorescence spectra by forming an inhibitor‐α‐glucosidase complex. Molecular docking results further indicated that the driving powers of the interaction between proanthocyanidins and α‐glucosidase were hydrogen bonds and hydrophobic force. The main inhibitory mechanism of proanthocyanidins on α‐glucosidase may be due to the insertion of proanthocyanidins into the pocket of the enzyme altering the catalytic configuration of the active site in a manner, thus reducing substrate binding affinity. The findings of this work provided a new perspective that proanthocyanidins from PFF with a possibility to be used as novel natural anti‐diabetic agents in functional food industries.Practical ApplicationIn this study, Pyracantha fortuneana fruit proanthocyanidins with a yield of 3.05% were identified for the first time as predominantly constituted of procyanidin with A‐type and B‐type linkage and coexistence of procyanidins glucoside. Proanthocyanidins from P. fortuneana fruit had higher anti‐α‐glucosidase activity value compared with positive control acarbose, which indicated that P. fortuneana fruit proanthocyanidins with a possibility to be used as novel natural antidiabetic agents in functional food industries.
Salvage radiotherapy for regional lymph node oligo‐recurrence after radical surgery of non‐small cell lung cancer
Authors: Seol Ki Ho , Lee Jeong Eun , Cho Joon Yong , Lee Deok Heon , Seok Yangki , Kang Min Kyu 
Published: September 2017

BackgroundCurrently, evidence‐based guidelines for salvage therapy to treat mediastinal lymph node (LN) oligo‐recurrence in post‐resection non‐small cell lung cancer (NSCLC) are limited. In patients previously treated by surgery without irradiation, radiotherapy (RT) might be safely utilized. We evaluate the clinical outcomes of salvage RT for patients with LN oligo‐recurrence that developed after radical surgery for NSCLC.MethodsThirty‐one patients with stage I–IIIA NSCLC who developed regional LN oligo‐recurrence between 2008 and 2013 were reviewed. The median time from surgery to recurrence was 12 months. Fifteen patients (48.4%) had single LN recurrence. All patients were irradiated by 3‐dimensional conformal RT at the recurrent LN area with daily fractions of 2–3 Gy, with a median dose of 66 Gy (range 51–66). Sixteen patients also received chemotherapy.ResultsAfter salvage RT, 16 patients achieved a complete response, nine a partial response, and six had stable disease. The median follow‐up was 14 months (range 3–76). One and two‐year in‐field control rates were 88.4% and 75.8%, respectively. One and two‐year progression‐free survival rates were 73.1% and 50.9%, respectively. Progression sites were predominantly distant. Ten of the 31 patients (32.3%) met the revised Response Evaluation Criteria for Solid Tumors for a complete response by the final follow‐up. Recurrent LN size (<3 vs. ≥3 cm) was a significant prognostic factor for progression‐free survival (P = 0.013).ConclusionSalvage RT for patients with regional LN oligo‐recurrence after radical surgery was an effective treatment option with an acceptable level of toxicity.
Current status of robotic surgery in urology
Authors: Honda Masashi , Morizane Shuichi , Hikita Katsuya , Takenaka Atsushi 
Published: September 2017

AbstractAs a result of ergonomics, optimal magnification of the operative field, surgeon dexterity, and precision of surgical manipulation, robotic technology has been shown to overcome many difficulties associated with pure laparoscopy. With the recent expansion of robot‐assisted surgery in the field of urology and following the success of robot‐assisted prostatectomy and robot‐assisted partial nephrectomy, robot‐assisted surgery is being applied to treat many other genitourinary diseases, such as bladder cancer and ureteropelvic junction obstruction. The aim of the present review is to discuss the role of robotic surgery in urology and summarize recent developments in the field of urologic robotic surgery.