bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stabilizing Hydrographic Profiles with Minimal Change to the Water Masses
Authors: Barker Paul M. , McDougall Trevor J. 
Published: June 2017

AbstractBoth observed and averaged oceanographic data often contain regions with density inversions. This paper presents two methods of stabilizing a water column. The first method is intended for use with observed data; it minimally adjusts Absolute Salinity while leaving the values of in situ temperature unchanged. The second method adjusts the values of both Absolute Salinity and Conservative Temperature, and these adjustments are made in such a way as to cause the least possible damage to the water-mass structure of the vertical cast.
Non-diagnostic thyroid nodules after application of the Bethesda system: a study evaluating the interval for repeat aspiration for non-diagnostic results
Authors: Yoon Jung Hyun , Kim Eun-Kyung , Kwak Jin Young , Moon Hee Jung 
Published: June 2017

Background The non-diagnostic category of the Bethesda system has a low malignancy rate; nevertheless, repeat ultrasonography-guided fine needle aspiration (US-FNA) is recommended with no consensus for follow-up intervals. Purpose To investigate whether a six-month time interval for repeat US-FNA is appropriate for non-diagnostic thyroid nodules after applying the Bethesda system. Material and Methods From January 2010 to January 2014, 322 thyroid nodules ≥10 mm with non-diagnostic results on initial US-FNA with any follow-up with US or US-FNA were included (mean age = 52.2 years ± 12.4). Clinical and US features were compared according to size change (increase, no change, decrease) and follow-up interval (<6 months and ≥6 months after initial US-FNA), and the minimal time interval observed in nodules with size increase on follow-up. The outcome of non-diagnostic nodules according to follow-up interval and size change were evaluated. Results Of the 322 nodules, 13 (4.0%) were malignant and 309 (96.0%) were benign. None of the 82 nodules with decreased size were malignant and 90.2% nodules with decreased size were found after six months. Of 175 nodules with repeat US-FNA, repeat cytology results did not differ significantly between the groups with follow-up US-FNA before and after six months ( P = 0.337). No significant differences were seen in size or extrathyroidal extension among the 13 malignant nodules according to the six-month interval (all P > 0.05), and no lateral lymph node metastasis was present. Conclusion Repeat US-FNA for initially non-diagnostic thyroid nodules can be performed at a six-month interval after initial procedure without tumor progression.
Anti-carbamylated protein antibodies in systemic lupus erythematosus patients with articular involvement
Authors: Massaro L , Ceccarelli F , Colasanti T , Pendolino M , Perricone C , Cipriano E , Natalucci F , Capalbo G , Lucchetti R , Pecani A , Vomero M , Mancini R , Spinelli F R , Alessandri C , Valesini G , Conti F 
Published: June 2017

Objective Several studies have evaluated the prevalence of rheumatoid factor (RF) and anti-citrullinated proteins antibodies (ACPA) in systemic lupus erythematosus (SLE) patients but no data are available on the anti-carbamylated proteins (anti-CarP), a new biomarker for rheumatoid arthritis (RA). We evaluated the anti-CarP prevalence in SLE patients with joint involvement and the associations with different phenotypes. Methods Seventy-eight SLE patients with joint involvement were enrolled (F/M 73/5; mean ± SD age 47.6 ± 11.2 years; mean ± SD disease duration 214.3 ± 115.6 months). As control groups, we evaluated SLE patients without joint manifestations ( N = 15), RA ( N = 78) and healthy individuals (HS, N = 98). Anti-CarP were assessed by home-made ELISA in all patients and controls, RF and ACPA in SLE patients with joint involvement (commercial ELISA kit). Results The prevalence of anti-CarP in SLE patients with joint involvement was similar to RA ( p = NS) and significantly higher compared with SLE without joint involvement and HS ( p < 0.0001, p < 0.0001, respectively). Four patients were positive for all three antibodies: seventy-five percent of these showed Jaccoud arthropathy. Fourty-five percent of ACPA-ve/RF-ve patients were anti-CarP + ve. Conclusions The evaluation of anti-CarP in SLE joint involvement demonstrated a prevalence of almost 50%, similar to RA and significantly higher than SLE without joint involvement and HS.
Outcomes of organ donation in brain-dead patient's families: Ethical perspective
Authors: Ahmadian Shamsi , Rahimi Abolfazl , Khaleghi Ebrahim 
Published: June 2017

Background: The families of brain-dead patients have a significant role in the process of decision making for organ donation. Organ donation is a traumatic experience. The ethical responsibility of healthcare systems respecting organ donation is far beyond the phase of decision making for donation. The principles of donation-related ethics require healthcare providers and organ procurement organizations to respect donor families and protect them against any probable harm. Given the difficult and traumatic nature of donation-related experience, understanding the outcomes of donation appears crucial. Objective: The aim of this study was to explore the outcomes of organ donation for the families of brain-dead patients. Methods: This was a qualitative descriptive study to which a purposeful sample of 19 donor family members were recruited. Data were collected through holding in-depth semi-structured interviews with the participants. Data analysis was performed by following the qualitative content analysis approach developed by Elo and Kyngäs. Findings: The main category of the data was “Decision to organ donation: a challenge from conflict to transcendence.” This main category consisted of 10 subcategories and 3 general categories. The general categories were “challenging outcomes,” “reassuring outcomes,” and “transcending outcomes.” Ethical considerations: The study was approved by the regional ethical review board. The ethical principles of informed consent, confidentiality, and non-identification were used. Conclusion: Donor families experience different challenges which range from conflict and doubtfulness to confidence, satisfaction, and transcendence. Healthcare providers and organ procurers should not discontinue care and support provision to donor families after obtaining their consent to donate because the post-decision phase is also associated with different complexities and difficulties with which donor families may not be able to cope effectively. In order to help donor families achieve positive outcomes from the tragedy of significant loss, healthcare professionals need to facilitate the process of achieving confidence and transcendence by them.
First-line use of contact aspiration for thrombectomy versus a stent retriever for recanalization in acute cerebral infarction: The randomized ASTER study protocol
Authors: Lapergue Bertrand , Labreuche Julien , Blanc Raphael , Barreau Xavier , Berge Jérome , Consoli Arturo , Rodesch Georges , Saleme Susanna , Costalat Vincent , Bracard Serge , Desal Hubert , Duhamel Alain , Baffert Sandrine , Mazighi Mikael , Gory Benjamin , Turjman Francis , Piotin Michel 
Published: June 2017

Rationale Mechanical thrombectomy with a stent retriever is now the standard of care in anterior circulation ischemic stroke caused by large vessel occlusion. New techniques for mechanical thrombectomy, such as contact aspiration, appear promising to increase reperfusion status and improve clinical outcome. Aim We aim at ascertaining whether contact aspiration is more efficient than the stent retriever as a first-line endovascular procedure. Sample size estimates With a two-sided test (alpha = 5%, power = 90%) and an anticipated rate of spontaneous recanalization and catheterization failures of 15%, we estimate that a sample size of 380 patients will be necessary to detect an absolute difference of 15% in primary outcome (superiority design). Methods and design The ASTER trial is a prospective, randomized, multicenter, controlled, open-label, blinded end-point clinical trial. Patients admitted with suspected ischemic anterior circulation stroke secondary to large vessel occlusion, with onset of symptoms <6 h, will be randomly assigned to contact aspiration or stent retriever in a 1:1 ratio; stratified by center and prior IV thrombolysis. If the assigned treatment technique is not successful after three attempts, another technique will be applied, at the operator’s discretion. Study outcomes The primary outcome will be successful recanalization (modified Thrombolysis in Cerebral Infarction score 2b–3) at the end of the endovascular procedures. Secondary outcome will include successful recanalization after the assigned first-line treatment technique alone, procedural times, the need for a rescue technique, complications and modified Rankin Scale at three months. Discussion No previous head to head randomized trials have directly compared contact aspiration versus stent retriever reperfusion techniques. This prospective trial aims to provide further evidence of benefit of contact aspiration versus stent retriever techniques among patients with ischemic stroke.
Using mHealth technologies to improve the identification of behavioral health problems in urban primary care settings
Authors: Staeheli Martha , Aseltine Robert H , Schilling Elizabeth , Anderson Daren , Gould Bruce 
Published: June 2017

Introduction: Behavioral health disorders remain under recognized and under diagnosed among urban primary care patients. Screening patients for such problems is widely recommended, yet is challenging to do in a brief primary care encounter, particularly for this socially and medically complex patient population. Methods: In 2013, intervention patients at an urban Connecticut primary clinic were screened for post-traumatic stress disorder, depression, and risky drinking (n = 146) using an electronic tablet-based screening tool. Screening data were compared to electronic health record data from control patients (n = 129) to assess differences in the prevalence of behavioral health problems, rates of follow-up care, and the rate of newly identified cases in the intervention group. Results: Results from logistic regressions indicated that both groups had similar rates of disorder at baseline. Patients in the intervention group were five times more likely to be identified with depression (p < 0.05). Post-traumatic stress disorder was virtually unrecognized among controls but was observed in 23% of the intervention group (p < 0.001). The vast majority of behavioral health problems identified in the intervention group were new cases. Follow-up rates were significantly higher in the intervention group relative to controls, but were low overall. Conclusion: This tablet-based electronic screening tool identified significantly higher rates of behavioral health disorders than have been previously reported for this patient population. Electronic risk screening using patient-reported outcome measures offers an efficient approach to improving the identification of behavioral health problems and improving rates of follow-up care.
Improvement of walking ability during postoperative rehabilitation with the hybrid assistive limb after total knee arthroplasty: A randomized controlled study
Authors: Tanaka Yohei , Oka Hiroyuki , Nakayama Shuichi , Ueno Takaaki , Matsudaira Ko , Miura Toshiki , Tanaka Kiyokazu , Tanaka Sakae 
Published: June 2017

Objective: We aimed to compare the efficacies of rehabilitation with the hybrid assistive limb and conventional rehabilitation after total knee arthroplasty. Materials and methods: A total of 37 consecutive patients who underwent primary total knee arthroplasty for knee osteoarthritis were enrolled. Seven patients withdrew from the study after randomization, and 30 patients (hybrid assistive limb group: n = 16; conventional group: n = 14) completed the randomized controlled trial. Patients in the hybrid assistive limb group underwent ten 20-min rehabilitation sessions with the hybrid assistive limb as well as 20-min conventional sessions over the course of 2 weeks, whereas patients in the conventional group received ten 40-min conventional sessions during the same period. The primary outcome measure was walking speed, whereas the secondary outcome measures included quadriceps strength and knee pain assessed using a numerical rating scale. The outcome measures were evaluated prior to surgery and on postoperative weeks 1, 2, and 3. Results: In the early postoperative period, rehabilitation after total knee arthroplasty with the hybrid assistive limb resulted in a significantly greater improvement in walking speed (weeks 1 and 2: p = 0.045), quadriceps strength (weeks 1 and 2; weeks 1 and 3: p < 0.0001), and numerical rating scale scores (week 1: p = 0.03) than conventional rehabilitation. Conclusion: Rehabilitation with the hybrid assistive limb after total knee arthroplasty led to greater improvements in walking speed, quadriceps strength, and pain scores than conventional rehabilitation.
Comparison of Pegged and Keeled Glenoid Components for Total Shoulder Arthroplasty
Authors: Khazzam Michael , Argo Madison , Landrum Matthew , Box Hayden 
Published: June 2017

Background Limited evidence exists regarding the relative rates of glenoid loosening after total shoulder arthroplasty utilizing pegged or keeled cemented all-polyethylene glenoid components. Methods A systematic review of level I, II, and III studies comparing the development of radiolucent lines and glenoid failure after total shoulder arthroplasty with pegged or keeled glenoid components was conducted. Four articles were included in the final analysis with a total of 203 total shoulder arthroplasties comprising 107 pegged and 96 keeled glenoid components. Results Development of radiolucent lines was less likely with pegged glenoid components with a risk difference of −0.32 (95% CI −0.62, −0.03) favoring the pegged design. There was no statistically significant difference in the rate of radiographically at-risk glenoids, clinical glenoid failure, or the composite endpoint. Conclusions Although the development of radiolucent lines was less likely around pegged glenoid components, there was no significant difference in the rate of radiographic or clinical glenoid failure between pegged and keeled components. More high-quality studies are needed to determine the relative rates of glenoid loosening with pegged and keeled glenoid components.
In vitro ion adsorption and cytocompatibility of dicalcium phosphate ceramics
Authors: Schamel Martha , Barralet Jake E. , Groll Jürgen , Gbureck Uwe 
Published: June 2017

Abstract

Background

In vitro
cell testing of degradable bioceramics such as brushite or monetite is often challenging due to the ion release into or adsorption from the culture medium. These ionic changes are then mostly responsible for cell proliferation and activity, which prohibits the investigation of effects originating from surface topography or further material modifications.

Methods

Here, we aimed to solve this problem by developing a pre-conditioning regime following the repeated immersion of brushite and monetite samples in various Ca
2+
, Mg
2+
and PO
4
3−
containing electrolytes, followed by studying ion adsorption / release as well as changes in phase composition and in vitro cytocompatibility with MG63 cells.

Results

The results demonstrated that by using DMEM cell culture medium in a ratio of 10 ml/sample was sufficient to minimize changes of ionic composition after 7 d with a daily change of the medium. This leads to changes of the surface composition with dissolution of the brushite phase. In turn, this also positively influences the
in vitro
cytocompatibility with a 2–3 fold higher cell number and cell activity on the DMEM pretreated surfaces.

Conclusions
Controlled sample washing prior to cell testing using DMEM medium seems to be a valuable procedure not only to stabilize the pH during cell culture but also to maintain ion concentrations within a cell friendly range.
Computerised cognitive–behavioural therapy for adults with intellectual disability: randomised controlled trial
Authors: Cooney Patricia , Jackman Catherine , Coyle David , O'Reilly Gary 
Published: June 2017

BackgroundDespite the evidence base for computer-assisted cognitive–behavioural therapy (CBT) in the general population, it has not yet been adapted for use with adults who have an intellectual disability.AimsTo evaluate the utility of a CBT computer game for adults who have an intellectual disability.MethodA 2 × 3 (group × time) randomised controlled trial design was used. Fifty-two adults with mild to moderate intellectual disability and anxiety or depression were randomly allocated to two groups: computerised CBT (cCBT) or psychiatric treatment as usual (TAU), and assessed at pre-treatment, post-treatment and 3-month follow-up. Forty-nine participants were included in the final analysis.ResultsA significant group x time interaction was observed on the primary outcome measure of anxiety (Glasgow Anxiety Scale for people with an Intellectual Disability), favouring cCBT over TAU, but not on the primary outcome measure of depression (Glasgow Depression Scale for people with a Learning Disability). A medium effect size for anxiety symptoms was observed at post-treatment and a large effect size was observed after follow-up. Reliability of Change Indices indicated that the intervention produced clinically significant change in the cCBT group in comparison with TAU.ConclusionsAs the first application of cCBT for adults with intellectual disability, this intervention appears to be a useful treatment option to reduce anxiety symptoms in this population.
Special Aspects of Innovation Activity of Primary School Teacher
Authors: Беловицкая  , Belovickaya S. 
Published: June 2017

The article considers the ability of primary school teachers to improve the quality of school education by introducing innovation activity in the educational process. Requirements for professional knowledge and methodological skills of teacher and innovator, as well as his personal qualities are given. In the particular example the stages of formation at younger schoolboys of educational action as an important component of
the innovation teacher are described. The conclusion is made that the degree of personal responsibility of the students for learning process and the learning outcomes of their cognitive activity is largely dependent on the effectiveness of innovative activity of the teacher.
Not Just a Fad: Optimal Sequencing in Mobile In-App Advertising
Authors: Sun Zhen , Dawande Milind , Janakiraman Ganesh , Mookerjee Vijay 
Published: June 2017

In this paper, we address the challenge faced by ad networks in managing the fading ads (or fads) shown to an end user during a session of a mobile application (app). A fad is an ad that disappears if the user does not interact with it for some length of time. The withdrawn ad could be replaced by another ad. The goal of the ad network is to determine the sequence of fads shown to the user in an ad space to maximize the expected revenue generated over the user’s app session. Mobile in-app advertising is uniquely suited for the sequencing of fads because user sessions are typically longer (than web sessions), and a single ad is displayed at any given point in time. We consider two factors that affect the probability of a click on an ad during a session: (i) the sojourn effect, the influence of the passage of time, and (ii) the exposure effect, the influence of the number of prior exposures of the ad to the user during that session. We provide simple and optimal policies for the ad-sequencing problem when either of these two effects dominates. For the general case in which both effects are significant, we offer a provably near-optimal heuristic policy. The following two enhancements to the basic sequencing problem are also analyzed: (a) consideration of both click ads (which generate revenue for the ad network only through clicks) and display ads (which generate revenue only through exposures) and (b) the presence of a constraint imposed by the publisher (i.e., the owner of the app) that the expected revenue in each time slot exceeds a certain threshold. The online appendix is available at https://doi.org/10.1287/isre.2017.0697 .
From context to subject: The poetics and politics of creating and exhibiting artworks in the National Museum of China
Authors: Yin Tongyun 
Published: June 2017

Abstract
Prior to its renovation and reopening in 2011, the National Museum of China, originally the Museum of Chinese History and the Museum of Chinese Revolution sharing the same building structure, has been the official trustee and the authoritative voice of Chinese history since 1949. However, in the past five years, the Museum has significantly shifted its focus from history to art as the pace of the nation’s socioeconomic transition accelerated, a tendency summarized in its mission to transform the Museum into the “largest art and history museum” in the world. Based on the studies of the exhibitions held at the Museum in the past few decades, this paper examines the transformation of the exhibitionary practices of the NMC first through the lens of artworks created by official commissions in Socialist China and by reconstructing cultural relics into ‘Chinese art’ in post-Socialist China. Then, it analyses the altering interpretative narratives and presentational approaches used to exhibit artworks against the nation’s rapidly changing social-cultural and economic contexts. The article aims to analyse the changing roles played by art to foster and uphold shifting discourses to justify the Party-State’s political legitimation and promote cultural nationalism for nation-building. It further reveals how power, politics and ideology operate in exhibitions in contemporary China.
Between global models and local resources: Building private art museums in Shanghai’s West Bund
Authors: Zennaro Giulia 
Published: June 2017

Abstract
Increasingly, the establishment of museums has developed as a strategy for improving local attractiveness and economy. Recently, in China, art museums – often in private form – have witnessed a rapid development. However, despite enhanced governmental support, some of these new art endeavours still face challenges in their operation. I argue that a major factor contributing to these obstacles can be found in the relation between local governments’ ambitions to design museums similarly to other world-renowned ones (isomorphism) and the availability of local resources and expertise. In particular, my case study on the Long Museum and the Yuz Museum (in the Shanghai West Bund) shows how focusing on the achievement of globally favoured aesthetic standards vis-à-vis local resources to enhance the credibility of these new undertakings (legitimacy) has occasionally obstructed organizational efficiency, specifically in this case, of the museums’ function to store and display art.
Unitals with many Baer secants through a fixed point
Authors: Rottey Sara , Van de Voorde Geertrui 
Published: June 2017

Abstract
We show that a unital U in PG(2, q
2) containing a point P, such that at least q
2 − ϵ of the secant lines through P intersect U in a Baer subline, is an ovoidal Buekenhout–Metz unital (where ϵ ≈ 2q for q even and ϵ ≈ q
3/2/2 for q odd).