bluuebunny/crossref_metadata_2025_split huggingface dataset:
Color duplex ultrasonography versus handheld Doppler to plan anterior lateral thigh flaps
Authors: Lethaus Bernd , Loberg Christina , Kloss‐Brandstätter Anita , Bartella Alexander K. , Steiner Timm , Modabber Ali , Hölzle Frank , Teichmann Jan 
Published: March 2017

BackgroundThe anterior lateral thigh flap (ALT) has become increasingly important in reconstructive surgery in the head and neck region. To cope with the problem of anatomical variability in the supplying blood vessels, preoperative evaluation is desirable. Purpose of the study is to compare the most commonly used Doppler devices Handheld Doppler (HD) and Color Doppler Ultrasonography (CDU) for their clinical reliability.MethodsForty five consecutive head and neck cancer patients (mean age 66.0 ± 11.2 years) were included in the study. They all underwent a reconstruction via ALT flap for a defect in the head and neck area. Study period ranged from May 2014 to August 2015. We preoperatively conducted HD and CDU on the lateral thigh and compared the intraoperative findings by measuring presence of the perforator and distance to the estimated position.ResultsThere were 95 perforators identified in 45 patients. The sensitivity and positive predictive value (PPV) were calculated as 97.9% and 100% for CDU and 90.5% and 80.4% for HD, respectively. Accuracy was significantly greater with the HD compared to the CDU device (P < 0.001) and was strongly associated with body mass index (BMI) (P < 0.001). This effect was stronger in HD than in CDU (r = 0.800; P < 0.001 versus r = 0.673; P < 0.001).ConclusionsOur results indicate CDU is more precise and reliable than HD with respect to detecting the anatomical position of perforating arteries. © 2017 Wiley Periodicals, Inc. Microsurgery 37:388–393, 2017.
Peripheral and central fatigue after high intensity resistance circuit training
Authors: Márquez Gonzalo , Romero‐Arenas Salvador , Marín‐Pagán Cristian , Vera‐Ibañez Antonio , FernáNdez Del Olmo Miguel , Taube Wolfgang 
Published: March 2017

ABSTRACTIntroductionThe aim of this study was to investigate the effects of high intensity resistance circuit (HIRC) and traditional strength training (TST) on neuromuscular fatigue and metabolic responses.MethodsTwelve trained young subjects performed HIRC and TST in a counterbalanced order with 1 week rest in‐between. The amount of workload and the inter‐set time for each local muscle group were matched (180 s), however, the time between successive exercises differed. The twitch interpolation technique was used to test neuromuscular function of the knee extensor muscles. Blood lactate concentration was used to evaluate metabolic responses.ResultsMaximum voluntary contraction and resting potentiated twitch amplitude (Qtw) were significantly reduced after HIRC, but there were not changes after TST, while reductions in voluntary activation were similar. Lactate concentration increased significantly more after HIRC.ConclusionsThe higher lactate concentration after HIRC probably impaired excitation‐contraction coupling, indicating larger peripheral fatigue than after TST. Muscle Nerve 56: 152–159, 2017.
Effect of resistance training with vibration and compression on the formation of muscle and bone
Authors: Zinner Christoph , Baessler Bettina , Weiss Kilian , Ruf Jasmine , Michels Guido , Holmberg Hans‐Christer , Sperlich Billy 
Published: March 2017

ABSTRACTIntroductionIn this study we investigated the effects of resistance training with vibration in combination with leg compression to restrict blood flow on strength, muscle oxygenation, muscle mass, and bone formation.MethodsTwelve participants were tested before and after 12 weeks of resistance training with application of vibration (VIBRA; 1–2 mm, 30 Hz) to both legs and compression (∼35 mm Hg, VIBRA+COMP) to only 1 leg.ResultsVIBRA+COMP and VIBRA improved 1 repetition maximum (1‐RM), increased the number of repetitions preceding muscle exhaustion, enhanced cortical bone mass, and lowered the mass and fat fraction in the thigh, with no changes in total muscle mass. The mass of cancellous bone decreased to a similar extent after VIBRA and VIBRA+COMP.DiscussionResistance training with VIBRA+COMP and VIBRA improved 1‐RM, increased the number of repetitions preceding muscular exhaustion, and enhanced formation of cortical bone, with no alteration of muscle mass. Muscle Nerve 56: 1137–1142, 2017
Best practice policy statement on urodynamic antibiotic prophylaxis in the non‐index patient
Authors: Cameron Anne P. , Campeau Lysanne , Brucker Benjamin M. , Clemens J. Quentin , Bales Gregory T. , Albo Michael E. , Kennelly Michael J. 
Published: March 2017

AimsAntibiotic prophylaxis before urodynamic testing (UDS) is widely utilized to prevent urinary tract infection (UTI) with only limited guidance. The Society of Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction (SUFU) convened a Best Practice Policy Panel to formulate recommendations on the urodynamic antibiotic prophylaxis in the non‐index patient.MethodsRecommendations are based on a literature review and the Panel's expert opinion, with all recommendations graded using the Oxford grading system.ResultsAll patients should be screened for symptoms of UTI and undergo dipstick urinalysis. If the clinician suspects a UTI, the UDS should be postponed until it has been treated. The first choice for prophylaxis is a single oral dose of trimethoprim‐sulfamethoxazole before UDS, with alternative antibiotics chosen in case of allergy or intolerance. Individuals who do NOT require routine antibiotic prophylaxis include those without known relevant genitourinary anomalies, diabetics, those with prior genitourinary surgery, a history of recurrent UTI, post‐menopausal women, recently hospitalized patients, patients with cardiac valvular disease, nutritional deficiencies or obesity. Identified risk factors that increase the potential for UTI following UDS and for which the panel recommends peri‐procedure antibiotics include: known relevant neurogenic lower urinary tract dysfunction, elevated PVR, asymptomatic bacteriuria, immunosuppression, age over 70, and patients with any indwelling catheter, external urinary collection device, or performing intermittent catheterization. Patients with orthopedic implants have a separate risk stratification.ConclusionsThese recommendations can assist urodynamic providers in the appropriate use of antibiotics for UDS testing. Clinical judgment of the provider must always be considered.
Comparison of three methods to analyze detrusor contraction during micturition in men over 50 years of age
Authors: Donkelaar S Celine ten , Rosier Peter , de Kort Laetitia 
Published: March 2017

AimsTo grade detrusor voiding contraction three parameters are used: the Schäfer pressure‐flow nomogram (LinPURR), the bladder contractility index (BCI) and the maximum Watt factor (Wmax). Because these methods to quantify detrusor contraction and/or to diagnose detrusor underactivity (DU) have not yet been mutually compared, this study compares these three methods of grading detrusor contraction.Materials and MethodsEvaluated were 1420 urodynamic pressure‐flow studies from 1222 men (aged >50 years) with lower urinary tract symptoms (LUTS). Excluded were patients with abnormal urinalysis, neurological disorders, surgical correction of congenital anomalies, pelvic surgery, post radical prostatectomy, or with evidence of urethral stricture. Contractility was graded with the LinPURR, the BCI, and Wmax, making a distinction between “strong,” “normal,” “weak,” and “very weak” contractility. We calculated agreement between LinPURR and both BCI and Wmax.ResultsThe contractility groups LinPURR and BCI, as well as LinPURR and Wmax, showed a high agreement of 97.5% and 80.9%, respectively.ConclusionThis study demonstrates a significant correlation in grading detrusor contractility when comparing LinPURR with the BCI (97.5% agreement) and the Wmax (80.9% agreement). The LinPURR is plausible, and applicable in clinical practice and BCI is (intrinsically) well associating with the LinPURR classes, on a more continuous scale. Both are relevant to define clinically relevant patients groups.
Videourodynamic analysis of the urethral sphincter overactivity and the poor relaxing pelvic floor muscles in women with voiding dysfunction
Authors: Peng Chung‐Hsin , Chen Sheng‐Fu , Kuo Hann‐Chorng 
Published: March 2017

AimsVoiding dysfunction due to dysfunctional voiding (DV) and poor relaxation of the external sphincter (PRES) are commonly found among adult women with lower urinary tract symptoms (LUTS) during videourodynamic study (VUDS). This study analyzed the VUDS characteristics of DV and PRES in female voiding dysfunction.MethodsThis retrospective study involved 1914 women aged >18 years with refractory LUTS. The medical records and the VUDS parameters were reviewed. Patients diagnosed with DV and PRES participated in the study. The VUDS characteristics and urethral sphincter activities were compared with those of urodynamically normal women.ResultsOf the 1914 women, 325 (17.0%) and 336 (17.6%) were diagnosed with DV and PRES, respectively. Detrusor overactivity (DO) occurred in 60% of the women with DV and in 5.7% of the women with PRES. Patients with DV had significantly increased bladder sensation, lower cystometric bladder capacity (CBC), lower bladder compliance, higher voiding detrusor pressure, smaller voided volume (VV), larger post‐void residual volume (PVR), lower voiding efficiency (VE), and higher bladder outlet obstruction index (BOOI) than the women with PRES and the control individuals. Patients with PRES had significantly increased bladder sensation, lower CBC, lower maximum flow rate, smaller VV, larger PVR, and lower VE than the control individuals.ConclusionsDV and PRES were highly prevalent among the adult women with voiding dysfunction. Patients with DV had VUDS characteristics of BOO and urodynamic DO. The clinical symptoms of PRES were similar to those of DV, but the patients had low detrusor contractility and low DO rates.
Registries in European post‐marketing surveillance: a retrospective analysis of centrally approved products, 2005–2013
Authors: Bouvy Jacoline C. , Blake Kevin , Slattery Jim , De Bruin Marie L. , Arlett Peter , Kurz Xavier 
Published: March 2017

AbstractPurposeRegulatory agencies and other stakeholders increasingly rely on data collected through registries to support their decision‐making. Data from registries are a cornerstone of post‐marketing surveillance for monitoring the use of medicines in clinical practice. This study was aimed at gaining further insight into the European Medicines Agency's (EMA) requests for new registries and registry studies using existing registries and to review the experience gained in their conduct.MethodsEuropean Public Assessment Reports were consulted to identify products for which a request for a registry was made as a condition of the marketing authorisation. All centrally authorised products that received a positive opinion of the EMA Committee for Medicinal Products for Human Use between 1 January 2005 and 31 December 2013 were included. Data regarding registry design and experiences were collected from EMA electronic record keeping systems.ResultsOf 392 products that received a positive Committee for Medicinal Products for Human Use opinion during 2005–2013, 31 registries were requested for 30 products in total. Sixty‐five percent were product registries whereas 35% were disease registries and 71% of the registries had a primary safety objective. Most commonly reported issues with registries were delayed time to start and low patient accrual rates.ConclusionsThe delays found in getting new registries up and running support the need to improve the timeliness of data collection in the post‐marketing setting. Methodological challenges met in conducting this study highlighted the need for a clarification of definitions and epidemiological concepts around patient registries. The results will inform the EMA Patient Registry initiative to support use of existing patient registries for the post‐authorisation benefit–risk monitoring of medicinal products. © 2017 Commonwealth of Australia. Pharmacoepidemiology & Drug Safety © 2017 John Wiley & Sons, Ltd.
Pain, depressive symptoms and medication in German patients with rheumatoid arthritis—results from the linking patient‐reported outcomes with claims data for health services research in rheumatology (PROCLAIR) study
Authors: Jobski Kathrin , Luque Ramos Andres , Albrecht Katinka , Hoffmann Falk 
Published: March 2017

AbstractPurposePain and depressive symptoms are common in patients with rheumatoid arthritis (RA). Information on the prevalence and treatment of both conditions in German RA patients is scarce.MethodsUsing data from a nationwide statutory health insurance fund (BARMER GEK), 6193 RA patients aged 18 to 79 years were provided with a questionnaire covering a variety of items such as demographics, medical condition and quality of life in 2015. Pain caused by the joint disorder (11‐point scale) was classified as none existent/mild, moderate or severe. Depressive symptoms were determined using the World Health Organization's five‐item Well‐being Index and categorized as none existent, mild or moderate/severe. Another item covered additional use of over‐the‐counter drugs. Data were linked to dispensation records.ResultsA total of 3140 RA patients were included. Median age was 66 years (79% female). About 70% of patients were classified as having moderate or severe pain. Depressive symptoms were found in 52% and were far more common among patients with higher pain levels. Analgesic treatment ranged from 45% to 76% (non‐opioid analgesics) and from 6% to 33% (opioids) in patients with no/mild pain and those reporting severe pain, respectively. In patients reporting moderate or severe pain, substantially higher prevalences of opioid use were observed among those with depressive symptoms. Depending on depressive symptoms, antidepressant use ranged from 7% to 37%. Overall, over‐the‐counter drug use varied between 30% and 59%.ConclusionsPain and depressive symptoms are highly prevalent in German RA patients, often present together and influence each other's treatment. Copyright © 2017 John Wiley & Sons, Ltd.
NMR solution structure of the RED subdomain of the Sleeping Beauty transposase
Authors: Konnova Tatiana A. , Singer Christopher M. , Nesmelova Irina V. 
Published: March 2017

AbstractDNA transposons can be employed for stable gene transfer in vertebrates. The Sleeping Beauty (SB) DNA transposon has been recently adapted for human application and is being evaluated in clinical trials, however its molecular mechanism is not clear. SB transposition is catalyzed by the transposase enzyme, which is a multi‐domain protein containing the catalytic and the DNA‐binding domains. The DNA‐binding domain of the SB transposase contains two structurally independent subdomains, PAI and RED. Recently, the structures of the catalytic domain and the PAI subdomain have been determined, however no structural information on the RED subdomain and its interactions with DNA has been available. Here, we used NMR spectroscopy to determine the solution structure of the RED subdomain and characterize its interactions with the transposon DNA.
Human male infertility and its genetic causes
Authors: Miyamoto Toshinobu , Minase Gaku , Shin Takeshi , Ueda Hiroto , Okada Hiroshi , Sengoku Kazuo 
Published: March 2017

AbstractBackgroundInfertility affects about 15% of couples who wish to have children and half of these cases are associated with male factors. Genetic causes of azoospermia include chromosomal abnormalities, Y chromosome microdeletions, and specific mutations/deletions of several Y chromosome genes. Many researchers have analyzed genes in the AZF region on the Y chromosome; however, in 2003 the SYCP3 gene on chromosome 12 (12q23) was identified as causing azoospermia by meiotic arrest through a point mutation.MethodsWe mainly describe the SYCP3 and PLK4 genes that we have studied in our laboratory, and add comments on other genes associated with human male infertility.ResultsUp to now, The 17 genes causing male infertility by their mutation have been reported in human.ConclusionsInfertility caused by nonobstructive azoospermia (NOA) is very important in the field of assisted reproductive technology. Even with the aid of chromosomal analysis, ultrasonography of the testis, and detailed endocrinology, only MD‐TESE can confirm the presence of immature spermatozoa in the testes. We strongly hope that these studies help clinics avoid ineffective MD‐TESE procedures.
Overexpression of microRNA‐542‐3p attenuates the differentiating capacity of endometriotic stromal cells
Authors: Sultana Shamima , Kajihara Takeshi , Mizuno Yumi , Sato Tomomi , Oguro Tatsuo , Kimura Machiko , Akita Masumi , Ishihara Osamu 
Published: March 2017

AbstractAimEndometriosis is defined as the presence of endometrial glandular and stromal cells outside of the uterine cavity. A previous study reported that microRNA (miR)‐542‐3p plays a critical role in eutopic endometrial decidualization. This study aims to clarify the potential role of miR‐542‐3p and the target gene, IGFBP‐1 (insulin‐like growth factor‐binding protein 1), in the impairment of the decidualizing capacity of human ectopic endometrial stromal cells (HEcESCs).MethodsIn vitro analysis of primary undifferentiated and decidualizing human eutopic endometrial stromal cells (HEuESCs) and HEcESCs was conducted. The primary HEuESCs or HEcESCs were expanded in culture and decidualized with 8‐bromo‐cyclic adenosine monophosphate (8‐bromo‐cAMP) and medroxyprogesterone acetate (MPA).ResultsThe morphological and biological differentiating capacities of the HEcESCs were markedly impaired. In contrast to the HEuESCs, the HEcESCs that were treated with the decidual stimulus retained the mesenchymal phenotype and capacity for migration. The down‐regulation of miR‐542‐3p in the HEcESCs treatment with 8‐bromo‐cAMP and MPA was much weaker than that of the HEuESCs. High expression of miR‐542‐3p led to a significant decrease in the expression of IGFBP1 in the HEcESCs.ConclusionImpairment of the differentiating capacity by the overexpression of miR‐542‐3p could influence the capacity for migration and invasion of endometriotic cells in an ectopic environment.
Employee‐based Innovation in Organizations: Overcoming Strategic Risks from Opportunism and Governance
Authors: Pandher Gurupdesh S. , Mutlu Gulseren , Samnani Al‐Karim 
Published: March 2017

Research summaryEmployees performing everyday tasks frequently acquire valuable new ideas and knowledge. Our formal analysis studies how organizations can benefit from employee‐driven innovation by using incentives to overcome strategic risk from opportunism and governance. We use a game theory framework to analyze the strategic interactions involved and identify incentives under which valuable ideas will be revealed without appropriation (in equilibrium). Our analysis considers both the short run and the long run, where governance can be adjusted to maximize expected future innovation profits. Innovation value, frequency, governance quality, and employee contestation costs are shown to play a salient role in determining the innovation incentives and equilibrium. Overall, our analysis and results provide a number of insights on how organizations can overcome frictions from strategic innovation risks to more fully mobilize their innovation potential and knowledge‐based resources.Managerial summaryIdea theft can occur in organizations when employees find it beneficial to present a valuable idea of another employee as theirs. If employees engaged in everyday tasks believe this will likely happen or that they will not be rewarded enough, they may not reveal them. We analyze the design of appropriate innovation rewards that will prevent stealing of innovative ideas and allow organizations to capture value from employee‐driven innovation. We show that governance quality, innovation value, and costs related to contestation play a salient role in determining appropriate innovation rewards and the organization's innovation capacity. “Flatter” organizations can deter idea theft more effectively and need to pay lower innovation rewards. In the long term, we show that all organizations can become more innovative by adjusting their governance quality and reducing employee contestation costs. Further, the ones with higher innovation potential and contestation costs will move toward higher quality governance and seek more entrepreneurial employees, as this raises long‐run innovation profits. Copyright © 2017 Strategic Management Society.
Functional Substituted Phthalocyanines Bearing Ter–pyridine Complexes as Macromolecular Oxidation Catalysts for Bleaching Systems
Authors: Sen Pinar , Yildiz S. Zeki , Dege Necmi , Atakay Mehmet , Salih Bekir 
Published: March 2017

AbstractThe present study dealing with the oxidation catalysts using in laundry bleaching process comprises of the complexion of 4’‐(N‐2‐phthalonitrile‐N‐methylamino)‐2,2’:6’,2’’‐terpyridine (2) with the related MnCl2.4H2O and CoCl2.6H2O salts in ethanol to obtain 4’‐(N‐2‐phthalonitrile‐N‐methylamino)‐2,2’:6’,2’’‐terpyridine‐Mn (II) complex (3) and 4’‐(N‐2‐phthalonitrile‐N‐methylamino)‐2,2’:6’,2’’‐terpyridine‐Co (II) complex (4). Terpyridine metal complexes substituted Zinc phthalocyanines, Tetrakis [4’‐(N‐2‐phthalonitrile‐N‐methylamino)‐2, 2’: 6’, 2’’‐terpyridine‐Mn(II) complex] phthalocyaninato zinc(II) (5) and Tetrakis [4’‐(N‐2‐phthalonitrile‐N‐methylamino)‐2,2’:6’,2’’‐terpyridine‐Co(II) complex] phthalocyaninato zinc(II) (6) were also prepared by the tetramerization of the terpyridine‐metal complexes (3, 4) in the presence of ZnCl2. FT‐IR, 1H‐NMR, 13C‐NMR, UV‐Vis, ESI‐MS and MALDI‐MS spectra were applied to characterize the prepared compounds. 4‐nitrophthalonitrile and some other starting materials crystallized in the synthetic pathway. 4‐nitrophthalonitrile crystalizes in different morphology and 4’‐(N‐2‐ Hydroxyehyl‐N‐methylamino)‐2, 2’ : 6’, 2’’‐ terpyridine (1) crystallizes in the monoclinic, space group. The compound 2 and 3 crystallize in the monoclinic space group. The bleach performances of the prepared terpyridine complexes (3, 4) and their phthalocyanine derivatives (5, 6) were examined by the degradation of Morin dye by using online spectrophotometric method (OSM).
A Facile Regioselective Synthesis of New Class of Cyclopent[b]indole dispiro heterocycles via1,3‐Dipolar Cycloaddition protocol and in vitro Cytotoxic studies
Authors: Satheeshkumar Rajendran , Edatt Lincy , Kumar V. B. Sameer , Prasad Karnam Jayarampillai Rajendra 
Published: March 2017

AbstractThe construction of azomethine ylides in situ from acenaphthoquinone/isatin and secondary amino acids such as sarcosine and thiaproline with cyclopent[b]indole dipolarophilesin refluxing dioxane and methanol afforded novel class of cyclopent[b]indole dispiro heterocycles via 1,3‐dipolar cycloaddition reaction. The regio and stereochemistry of formation of the final product was concertedly assigned by proton, carbon and 2D NMR techniques. Among the synthesized dispiroheterocyclic compounds 4&7 are found to show better cytotoxic activity against HeLa and MCF‐7 with structure activity relationship (SAR) studies.