bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of exposure to tobacco smoke, arsenic, and phthalates on locally advanced cervical cancer treatment—preliminary results
Authors: Neamtiu Iulia A. , Bloom Michael S. , Dumitrascu Irina , Roba Carmen A. , Pop Cristian , Ordeanu Claudia , Balacescu Ovidiu , Gurzau Eugen S. 
Published: September 2016

BackgroundCancer research is a national and international priority, with the efficiency and effectiveness of current anti-tumor therapies being one of the major challenges with which physicians are faced.ObjectiveTo assess the impact of exposure to tobacco smoke, arsenic, and phthalates on cervical cancer treatment.MethodsWe investigated 37 patients with locally advanced cervical carcinoma who underwent chemotherapy and radiotherapy. We determined cotinine and five phthalate metabolites in urine samples collected prior to cancer treatment, by gas chromatography coupled to mass spectrometry, and urinary total arsenic by atomic absorption spectrometry with hydride generation. We used linear regression to evaluate the effects of cotinine, arsenic, and phthalates on the change in tumor size after treatment, adjusted for confounding variables.ResultsWe detected no significant associations between urinary cotinine, arsenic, or phthalate monoesters on change in tumor size after treatment, adjusted for urine creatinine, age, baseline tumor size, and cotinine (for arsenic and phthalates). However, higher %mono-ethylhexyl phthalate (%MEHP), a putative indicator of phthalate diester metabolism, was associated with a larger change in tumor size (β= 0.015, 95% CI [0.003–0.03],P= 0.019).ConclusionWe found no statistically significant association between the urinary levels of arsenic, cotinine, and phthalates metabolites and the response to cervical cancer treatment as measured by the change in tumor size. Still, our results suggested that phthalates metabolism may be associated with response to treatment for locally advanced cervical cancer. However, these observations are preliminary and will require confirmation in a larger, more definitive investigation.
Oberflächenmodifizierung von Wasseraufbereitungsmembranen
Authors: Miller Daniel J. , Dreyer Daniel R. , Bielawski Christopher W. , Paul Donald R. , Freeman Benny D. 
Published: September 2016

AbstractPolymermembranen sind ein energieeffizientes Mittel zur Aufbereitung von Wasser, ein Problem ist jedoch das Auftreten von Fouling während der Filtration. Ein Weg, Membran‐Fouling zu umgehen, ist die Modifizierung der Membranoberfläche, um eine höhere Wasserproduktivität aufrechtzuerhalten. Wir diskutieren hier eine Reihe gängiger Membranoberflächenmodifizierungstechniken, darunter Oberflächenbeschichtungen und Pfropfen, sowie verschiedene Behandlungsmethoden wie etwa chemische Behandlungen, UV‐Bestrahlung und Plasma‐Behandlungen. Die Diskussion wird in den historischen Hintergrund der Membranentwicklung und Oberflächenmodifizierung eingebunden. Wir stellen außerdem Polydopamin als ein neu entwickeltes Material für die Membranmodifizierung vor, das sich in einfacher Weise auf einer Vielzahl von Substraten aufbringen lässt.
Vinylboronic Acids as Fast Reacting, Synthetically Accessible, and Stable Bioorthogonal Reactants in the Carboni–Lindsey Reaction
Authors: Eising Selma , Lelivelt Francis , Bonger Kimberly M. 
Published: September 2016

AbstractBioorthogonal reactions are widely used for the chemical modification of biomolecules. The application of vinylboronic acids (VBAs) as non‐strained, synthetically accessible and water‐soluble reaction partners in a bioorthogonal inverse electron‐demand Diels–Alder (iEDDA) reaction with 3,6‐dipyridyl‐s‐tetrazines is described. Depending on the substituents, VBA derivatives give second‐order rate constants up to 27 m−1 s−1 in aqueous environments at room temperature, which is suitable for biological labeling applications. The VBAs are shown to be biocompatible, non‐toxic, and highly stable in aqueous media and cell lysate. Furthermore, VBAs can be used orthogonally to the strain‐promoted alkyne–azide cycloaddition for protein modification, making them attractive complements to the bioorthogonal molecular toolbox.
ChemInform Abstract: Mg9Si5: A Potential Non‐toxic Thermoelectric Material for Mid‐Temperature Applications.
Authors: Singh Vijeta , Pulikkotil J. J. , Auluck S. 
Published: September 2016

AbstractFirst principles density functional theory based calculations indicate Mg9Si5 to be a potential non‐toxic mid temperature thermoelectric material, operable in the 400—600 K range.
ChemInform Abstract: First 14‐Layer Twinned Hexagonal Perovskite Ba14Mn1.75Ta10.5O42: Atomic‐Scale Imaging of Cation Ordering.
Authors: Tao Fengqiong , Genevois Cecile , Lu Fengqi , Kuang Xiaojun , Porcher Florence , Li Liangju , Yang Tao , Li Wenbo , Zhou Di , Allix Mathieu 
Published: September 2016

AbstractPolycrystalline Ba14Mn1.75Ta10.5O42 (BMT) is prepared by calcination of a stoichiometric mixture of BaCO3, MnCO3, and Ta2O5 (Al2O3 crucible, 1473 K, 8 h), pelletizing, and further firing in air (1773 K, 12‐24 h).
ChemInform Abstract: Fei‐Phos Ligand‐Controlled Asymmetric Palladium‐Catalyzed Allylic Substitutions with Structurally Diverse Nucleophiles: Scope and Limitations.
Authors: Xu Jian‐Xing , Ye Fei , Bai Xing‐Feng , Zhang Jin , Xu Zheng , Zheng Zhan‐Jiang , Xu Li‐Wen 
Published: September 2016

AbstractThe allylic etherification of alcohols and the allylic alkylation of activated methylene compounds, indoles, and aromatic amines proceed with good yields and high enantioselectivity (up to 99% e.e.) employing Fei‐Phos as an effective phosphine ligand.
ChemInform Abstract: Copper‐Catalyzed Asymmetric Addition of Olefin‐Derived Nucleophiles to Ketones.
Authors: Yang Yang , Perry Ian B. , Lu Gang , Liu Peng , Buchwald Stephen L. 
Published: September 2016

AbstractEnantioenriched alcohols found in an array of bioactive natural products and pharmaceutical agents are often synthesized by asymmetric nucleophilic addition to carbonyls.
ChemInform Abstract: [4 + 2] Cycloadditions of Seven‐Membered‐Ring trans‐Alkenes: Decreasing Reactivity with Increasing Substitution of the Seven‐Membered Ring.
Authors: Santucci John III , Sanzone Jillian R. , Woerpel K. A. 
Published: September 2016

AbstractThe reactivity of trans‐oxasilacycloheptenes in [4+2] cycloadditions depends on the substitution pattern on the seven‐membered ring.
ChemInform Abstract: Heterogeneous Acidic and Eco‐Friendly Reagents for Mild and Convenient Conversion of Epoxides to 1,2‐Diacetates.
Authors: Gilanizadeh Masumeh , Zeynizadeh Behzad 
Published: September 2016

AbstractNa2HPO4·12H2O and NaHSO4·H2O prove to be efficient and eco‐friendly reagents for the highly regioselective ring‐opening of epoxides with Ar2O.
ChemInform Abstract: Iron‐Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes.
Authors: Zheng Yan‐Long , Liu Yan‐Yao , Wu Yi‐Mei , Wang Yin‐Xia , Lin Yu‐Tong , Ye Mengchun 
Published: September 2016

AbstractA reductive coupling of aldehydes with alkenes provides secondary alcohols through a direct hydride transfer pathway.
ChemInform Abstract: Palladium‐Catalyzed ortho‐Acylation of N‐Nitrosoanilines with α‐Oxocarboxylic Acids: A Convenient Method to Synthesize N‐Nitroso Ketones and Indazoles.
Authors: Zhang Liang , Wang Zhe , Guo Peiyu , Sun Wei , Li Ya‐Min , Sun Meng , Hua Chengwen 
Published: September 2016

AbstractVarious N‐Nitroso ketones are prepared by decarboxylative ortho‐acylation of N‐Nitroso compounds with α‐oxocarboxylic acids involving a N atom‐directed activation of C—H bonds.
ChemInform Abstract: CO2 Activation and Fixation: Highly Efficient Syntheses of Hydroxy Carbamates over Au/Fe2O3.
Authors: Shang Jianpeng , Guo Xiaoguang , Li Zuopeng , Deng Youquan 
Published: September 2016

AbstractAn efficient route for the synthesis of hydroxy carbamates via reaction of epoxides with amines and CO2 is developed.
ChemInform Abstract: Diels—Alder Cycloaddition of Tetraphenylcyclopentadienone and 1,3,5‐Hexatriynes.
Authors: Sale Anna Chiara , Murray Adrian H. , Prenzel Dominik , Hampel Frank , De Luca Lidia , Tykwinski Rik R. 
Published: September 2016

AbstractThe Diels—Alder reaction of tetraphenylcyclopentadienone with triynes (I) gives fully substituted benzenes in good yields.
ChemInform Abstract: Lipase‐Initiated One‐Pot Synthesis of Spirooxazino Derivatives: Redesign of Multicomponent Reactions to Expand Substrates Scope and Application Potential.
Authors: Chen Xiao‐Yang , Wang Jun‐Liang , Lin Xian‐Fu , Wu Qi 
Published: September 2016

AbstractAn improved enzymatic three‐component coupling reaction of β‐nitrostyrenes, cyclohexanones, and aldols to give hydrospirooxazinoindoles is presented.
ChemInform Abstract: Ecological Recycling of a Bio‐Based Catalyst for Cu Click Reaction: A New Strategy for a Greener Sustainable Catalysis.
Authors: Clave G. , Garoux L. , Boulanger C. , Hesemann P. , Grison C. 
Published: September 2016

AbstractThe Cu‐based ecocatalyst produced via rhizofiltration of copper‐rich effluents using E.
ChemInform Abstract: Microwave‐Assisted C‐2 Direct Alkenylation of Imidazo[4,5‐b]pyridines: Access to Fluorescent Purine Isosteres with Remarkably Large Stokes Shifts.
Authors: Baladi Tom , Granzhan Anton , Piguel Sandrine 
Published: September 2016

AbstractThe alkenylation reaction is rapid and compatible with various substituents in both partners to give 2‐alkynylimidazopyridines.
ChemInform Abstract: Iodine‐Catalyzed Synthesis of 5H‐Phthalazino[1,2‐b]quinazoline and Isoindolo[2,1‐a]quinazoline Derivatives via a Chemoselective Reaction of 2‐Aminobenzohydrazide and 2‐Formylbenzoic Acid in Ionic Liquids.
Authors: Jin Rong‐Zhang , Zhang Wen‐Ting , Zhou Yu‐Jing , Wang Xiang‐Shan 
Published: September 2016

AbstractThe type of the products depends on the steric effect in the reactant of the aminobenzohydrazides.
ChemInform Abstract: Sesquiterpenes from the Leaves of Nicotiana tabacum and Their anti‐Tobacco Mosaic Virus Activity.
Authors: Shen Qin‐Peng , Xu Xing‐Meng , Li Lan , Zhao Wei , Xiang Neng‐Jun , Yang Guang‐Yu , Chen Yong‐Kuan , Miao Ming‐Ming , Liu Chun‐Bo , Liu Zhi‐Hua 
Published: September 2016

AbstractTwo new pterosin‐type sesquiterpenes, nicosesquiterpenes A and B, are isolated along with four known sesquiterpene derivatives.
ChemInform Abstract: Conversion of β‐Glycopyranoside to α‐Glycopyranoside by Photo‐Activated Radical Reaction.
Authors: Lai Yu‐Chen , Luo Chin‐Hung , Chou Hsin‐Chun , Yang Cheng‐Jhang , Lu Le , Chen Chien‐Sheng 
Published: September 2016

AbstractThe halogen‐light‐activated anomeric inversion of glycosides is achieved by using CCl4 as the chlorine radical source and BF3.OEt2 as the Lewis acid.
ChemInform Abstract: Asymmetric Total Synthesis and Structural Elucidation of Unusual Oxindole Alkaloid Leucolusine.
Authors: Pandey Ganesh , Khamrai Jagadish 
Published: September 2016

AbstractThe total synthesis of both diastereomers of the unusual tetracyclic ring‐opened oxindole alkaloid leucolusine (I) is achieved.
Vegetation structure and photosynthesis respond rapidly to restoration in young coastal fens
Authors: Laine Anna M. , Tolvanen Anne , Mehtätalo Lauri , Tuittila Eeva‐Stiina 
Published: September 2016

AbstractYoung coastal fens are rare ecosystems in the first stages of peatland succession. Their drainage compromises their successional development toward future carbon (C) reservoirs. We present the first study on the success of hydrological restoration of young fens. We carried out vegetation surveys at six young fens that represent undrained, drained, and restored management categories in the Finnish land uplift coast before and after restoration. We measured plant level carbon dioxide (CO2) assimilation and chlorophyll fluorescence (Fv/Fm) from 17 most common plant species present at the sites. Within 5 years of restoration, the vegetation composition of restored sites had started to move toward the undrained baseline. The cover of sedges increased the most in response to restoration, while the cover of deciduous shrubs decreased the most. The rapid response indicates high resilience and low resistance of young fen ecosystems toward changes in hydrology. Forbs had higher photosynthetic and respiration rates than sedges, deciduous shrubs, and grasses, whereas rates were lowest for evergreen shrubs and mosses. The impact of management category on CO2 assimilation was an indirect consequence that occurred through changes in plant species composition: Increase in sedge cover following restoration also increased the potential photosynthetic capacity of the ecosystem. Synthesis and applications. Restoration of forestry drained young fens is a promising method for safeguarding them and bringing back their function as C reservoirs. However, their low resistance to water table draw down introduces a risk that regeneration may be partially hindered by the heavy drainage in the surrounding landscape. Therefore, restoration success is best safeguarded by managing the whole catchments instead of carrying out small‐scale projects.
Unraveling complex hydrogeological processes in Andean basins in south‐central Chile: An integrated assessment to understand hydrological dissimilarity
Authors: Muñoz Enrique , Arumí José Luis , Wagener Thorsten , Oyarzún Ricardo , Parra Victor 
Published: September 2016

AbstractGroundwater storage, drainage, and interbasin water exchange are common hydrological processes but often difficult to quantify due to a lack of local observations. We present a study of three volcanic mountainous watersheds located in south‐central Chile (~36.9 ° S) in the Chillán volcanic complex (Chillán, Renegado, and Diguillín river basins). These are neighboring basins that are similar with respect to the metrics normally available for characterization everywhere (e.g., precipitation, temperature, and land cover). In a hydrological sense, similar (proportional) behavior would be expected if these catchments would be characterized with this general information. However, these watersheds show dissimilar behavior when analyzed in detail. The surface water balance does not fit for any of these watersheds individually; however, the water balance of the whole system can be explained by likely interbasin water exchanges. The Renegado river basin has an average annual runoff per unit of area on the order of 60–65% less than those of the Diguillín and Chillán rivers, which is contradictory to the hydrological similarity among the basins. To understand the main processes that control streamflow generation, two analyses were performed: (a) basin metrics (land cover, geologic, topographic, and climatological maps) and hydro‐meteorological data analyses and (b) a water balance model approach. The analyses contribute to a plausible explanation for the hydrogeological processes in the system. The soils, topography, and geology of the Chillán–Renegado–Diguillín system favor the infiltration and groundwater movements from the Renegado river basin, mainly to the neighboring Diguillín basin. The interbasin water exchanges affect hydrological similarity and explain the differences observed in the hydrological processes of these three apparently similar volcanic basins. The results highlight the complexity of hydrological processes in volcanic mountainous systems and suggest that a simple watershed classification approach based on widely available data is insufficient. Simple local analyses such as specific flow analysis with a review of the geology and morphology can contribute to a better understanding of the hydrology of volcanic mountainous areas.
LOX Fails to Substitute for RANKL in Osteoclastogenesis
Authors: Tsukasaki Masayuki , Hamada Koki , Okamoto Kazuo , Nagashima Kazuki , Terashima Asuka , Komatsu Noriko , Win Stephanie J , Okamura Tadashi , Nitta Takeshi , Yasuda Hisataka , Penninger Josef M , Takayanagi Hiroshi 
Published: September 2016

ABSTRACT

Osteoclasts are the exclusive bone-resorbing cells that have a central role in bone homeostasis as well as bone destruction in cancer and autoimmune disease. Both mouse and human genetic studies have clearly proven that receptor activator of NF-κB ligand (RANKL; encoded by the Tnfsf11 gene) and its receptor RANK are essential for osteoclastogenesis. Although there have been several reports on RANKL-independent osteoclastogenesis, previous studies have never provided in vivo evidence showing RANKL can be substituted by other molecules using RANKL- or RANK-deficient genetic backgrounds. Thus, to date, there is no clear evidence of RANKL-independent osteoclastogenesis and no molecule has ever been proven capable of inducing osteoclast differentiation more efficiently than RANKL. Recently, lysyl oxidase (LOX), the enzyme that mediates collagen cross-linking, has been shown to induce human osteoclasts in the absence of RANKL and has a stronger osteoclastogenic activity than RANKL. Here, we investigated the effect of LOX on osteoclast differentiation using RANKL- and RANK-deficient cells to strictly explore RANKL-independent osteoclastogenesis. CD14+ human peripheral blood cells as well as osteoclast precursor cells derived from wild-type, RANKL- and RANK-deficient mice were treated with RANKL and/or LOX in short-term (3 days) or long-term (3 weeks) experimental settings. LOX treatment alone did not result in the formation of tartrate-resistant acid phosphatase (TRAP)+ cells or resorption pits in either short-term or long-term culture. In combination with RANKL, long-term treatment with LOX synergistically promoted osteoclastogenesis in cells derived from wild-type mice; however, this was abrogated in RANKL-deficient cells. Long-term treatment with LOX stimulated RANKL expression in mouse bone marrow stromal cells via the production of reactive oxygen species (ROS). Furthermore, LOX injection failed to rescue the phenotype of RANKL-deficient mice. These results suggest that LOX has the ability to induce RANKL expression on stromal cells; however, it fails to substitute for RANKL in osteoclastogenesis. © 2016 American Society for Bone and Mineral Research.
Naringenin‐Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways
Authors: Lim Whasun , Park Sunwoo , Bazer Fuller W. , Song Gwonhwa 
Published: September 2016

ABSTRACTProstate cancer is the most common cancer in men and the second most common cause of cancer‐related deaths in men. Although, various drugs targeting the androgen receptor are normally used, the patients frequently undergo recurrence of the disease. To overcome these limitations, natural compounds have been researched for evidence that they suppress progression and metastasis of various cancer cells. In the present study, we investigated effects of naringenin, a natural anti‐oxidant flavonoid derived from citrus, on prostate cancer cells (PC3 and LNCaP). Results of present study with PC3 and LNCaP cells revealed that naringenin inhibited proliferation and migration, while inducing apoptosis and ROS production by those cells. In addition, naringenin‐induced loss of mitochondrial membrane potential and increased Bax and decreased Bcl‐2 proteins in PC3 cells, but not LNCaP cells. In a dose‐dependent manner, naringenin decreased phosphorylation of ERK1/2, P70S6K, S6, and P38 in PC3 cells, and reduced phosphorylation of ERK1/2, P53, P38, and JNK proteins in LNCaP cells. However, naringenin activated phosphorylation of AKT in both PC3 and LNCaP cells. Then, targeted signaling proteins associated with viability of PC3 and LNCaP cells were analyzed using pharmacological inhibitors of AKT and ERK1/2 cell signaling pathways. Moreover, we compared the apoptotic effects of naringenin and paclitaxel alone and in combination to find that naringenin enhanced the efficiency of paclitaxel to suppress progression of prostate cancer cell lines. Collectively, these results indicate that naringenin is a potential chemotherapeutic agent for treatment of prostate cancer. J. Cell. Biochem. 118: 1118–1131, 2017. © 2016 Wiley Periodicals, Inc.
Fractional resurfacing in the Asian patient: Current state of the art
Authors: Wat Heidi , Wu Douglas C. , Chan Henry Hin Lee 
Published: September 2016

Background and ObjectiveFractionated photothermolysis (FP) has revolutionized modern laser technology. By creating selective columns of microthermal damage, fractionated devices allows for greater treatment depths to be achieved without the prolonged downtime and risk of complications seen in traditional fully ablative laser resurfacing. Fractional resurfacing is a proven method to treat a variety of cutaneous conditions. In the Caucasian patient, a wide range of devices and treatment settings can be utilized safely and effectively. However, ethnic skin requires special consideration due to its unique pigmentary characteristics and clinical presentations. In this review article, we detail the current indications and strategies to optimize results and mitigate complications when utilizing fractional resurfacing for the Asian patient.MethodsA review of the MEDLINE English literature was conducted on fractionated laser devices studied in the Asian population. Articles included describe non‐ablative devices including fractionated erbium glass, thulium fiber, diode, and radiofrequency devices; and ablative devices including fractionated carbon dioxide (CO2) laser, erbium yttrium aluminum garnet and yttrium scandium gallium garnet (YSGG) laser. These data were integrated with the expert opinion of the authors.ConclusionTaking into account the unique characteristics and cosmetic concerns of the Asian population, fractional resurfacing can be considered a safe and effective option for the treatment of atrophic and hypertrophic scarring, and photorejuvenation in ethnic skin types. Select cases of melasma may be treated with fractionated non‐ablative devices, but utilized with caution. The predominant complication associated with fractional resurfacing for these conditions is post‐inflammatory hyperpigmentation (PIH) and rebound worsening of melasma. A greater number of treatments at lower density settings and wider treatment intervals typically produce the lowest risks of PIH without compromising treatment efficacy. Lasers Surg. Med. 49:45–59, 2017. © 2016 Wiley Periodicals, Inc.