bluuebunny/crossref_metadata_2025_split huggingface dataset:
Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine
Authors: Guo Song , Vollesen Anne L.H. , Olesen Jes , Ashina Messoud 
Published: August 2016

Abstract
Migraine attacks are often preceded by premonitory symptoms (PS) that may be triggered pharmacologically. We investigated the incidence of PS after administration of calcitonin gene-related peptide (CGRP) or pituitary adenylate cyclase-activating peptide-38 (PACAP38) in patients with migraine without aura (MO) who reported and did not report migraine-like attacks induced by these pharmacological triggers. In addition, we investigated the association between PS and familial predisposition for migraine. In our study, MO patients received continuous intravenous infusion of α-CGRP (n = 40) and PACAP38 (n = 32) for 20 minutes. Premonitory and nonheadache symptoms were recorded by a self-administered questionnaire. Information on familial predisposition was obtained by telephone interview of first-degree relatives using a validated semistructured questionnaire. Twenty-five of 40 patients (63%) developed a migraine-like attack after CGRP infusion and 23 of 32 patients (72%) developed an attack after PACAP38 infusion. Only 2 patients (9%) with a CGRP-induced migraine-like attack reported PS, whereas 11 patients (48%) reported PS after PACAP38. Patients who developed a migraine-like attack did not report more PS than did patients with no attack after CGRP (P = 0.519) or PACAP38 (P = 0.103). Additionally, we found no difference in PS between patients with familial predisposition of migraine (75%) and patients with no family predisposition (56%) (P = 0.101). In conclusion, CGRP did not induce PS, whereas PACAP38 induced PS in 48% of patients. However, CGRP and PACAP38 did not induce more PS in patients who developed an attack compared with those who did not develop an attack.
Review of adult laryngotracheal stenosis: pathogenesis, management, and outcomes
Authors: Rosow David E. , Barbarite Eric 
Published: August 2016

Purpose of review
Adult laryngotracheal stenosis (LTS) is a potentially life-threatening disorder that can be difficult to diagnose and treat. Much is unknown regarding the etiology of airway stenosis, and while many patients do well with standard surgical management, the recurrence rate is significant. Few medical therapies exist, but there is a growing need.

Recent findings
Several basic science studies have shown a role of inflammatory signaling pathways in the development of LTS. Infectious processes may also play a role in development of stenosis, while treatment with anti-inflammatory and immunosuppressive medications has shown some promise in preventing disease. Several risk factors, such as diabetes, BMI, length of stenosis, and need for T-tube, have been identified that portend worse surgical outcomes and may assist physicians in choosing appropriate treatment.

Summary
While adult LTS is a complex, challenging clinical entity, there is promising research into the inflammatory origins of the disorder, which may open up groundbreaking new avenues of medical treatment.
Feelings of Loneliness and Living Alone as Predictors of Mortality in the Elderly: The PAQUID Study
Authors: Tabue Teguo Maturin , Simo-Tabue Nadine , Stoykova Ralitsa , Meillon Céline , Cogne Mélanie , Amiéva Hélène , Dartigues Jean-François 
Published: August 2016

ABSTRACT

Objective
The aim of this work was to determine the predictive value of 2 indicators of psychosocial isolation (living alone and feelings of loneliness) in elderly people.

Methods
Twenty-two-year follow-up cohort study of 3,620 community-dwelling elderly people enrolled in the PAQUID study, a French prospective population-based study. Participants completed a battery of tests including the Centre for Epidemiological Studies Depression scale and a question regarding living conditions (living alone or living with another person). Feelings of loneliness were measured using the Item 14 (“I felt lonely”) of the French version of the Centre for Epidemiological Studies Depression scale. Mortality rate was measured over a 22-year follow-up period after the baseline assessment visit. The risk of death was estimated using Cox proportional hazards models, adjusted for age, sex, and educational level.

Results
At baseline, 1,535 participants (42.4%) were living alone, and a total of 498 persons (13.8%) reported frequent feelings of loneliness (FoL). The participants reporting FoL were more frequently women (82.7%), and the mean (SD) age was 76.5 (7.1) years. At the end of the follow-up, 3,116 deaths (86.6%) occurred. Living alone and FoL were both independent predictors of death after 22 years of follow-up (hazard ratio, 1.14; 95% confidence of interval, 1.05–1.23; p = .001) and (hazard ratio, 1.20; 95% confidence of interval, 1.08–1.33; p = .001), respectively. No significant interaction was found between feelings of loneliness and living alone, suggesting that a joint exposure has only an additive effect (β = 0.08; relative risk = (0.85; 1.40); p = .48). The associations of both measures persisted after adjusting for health status. Adjusting for depression attenuated the predictive value of FoL.

Conclusions
Living alone and FoL were independently associated with higher risk of mortality. These factors may be useful as readily available psychosocial measures to identify vulnerability in community-dwelling older adults.
Occipital white matter tracts in human and macaque
Authors: Takemura Hiromasa , Pestilli Franco , Weiner Kevin S. , Keliris Georgios A. , Landi Sofia M. , Sliwa Julia , Ye Frank Q. , Barnett Michael A. , Leopold David A. , Freiwald Winrich A. , Logothetis Nikos K. , Wandell Brian A. 
Published: August 2016

AbstractWe compare the major white matter tracts in human and macaque occipital lobe using diffusion MRI. The comparison suggests similarities but also significant differences in spatial arrangement and relative sizes of the tracts. There are several apparently homologous tracts in the two species, including the vertical occipital fasciculus (VOF), optic radiation, forceps major, and inferior longitudinal fasciculus (ILF). There is one large human tract, the inferior fronto-occipital fasciculus, with no corresponding fasciculus in macaque. The macaque VOF is compact and its fibers intertwine with the dorsal segment of the ILF, but the human VOF is much more elongated in the anterior-posterior direction and may be lateral to the ILF. These similarities and differences will be useful in establishing which circuitry in the macaque can serve as an accurate model for human visual cortex.Contact informationHiromasa Takemura, Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, and Osaka University, Japanhtakemur@nict.go.jpAuthor contributionDesigned the study: HT FP BAW. Performed the experiments. HT FP GAK SML JS FQY DAL WAF NKL. Analyzed the data. HT FP KSW MAB BAW. Contributed analysis tools. FP KSW MAB. Wrote the paper. HT FP KSW BAW.
Paleochronic reversion inPsophocarpus, the decompression function in floral anatomic fields
Authors: Benya Edward. G.F. 
Published: August 2016

AbstractPaleochronic reversion (an atavism) inPsophocarpuspresents a basic floral phylloid ground state. That ground state can quickly change as permutation transformation (Tx) begins. The form of permutation can vary as phyllotactic phylloid (TPhyld) and/or floral axial decompression (TAxl) presenting linear elongation (TLong), rotational (TRtn) and/or lateral (TLat) components. Research with 70 reverted floral specimens documented varying degrees of phyllotactic permutation at the bracts (Bt) region and inter-bracts (IBS) sub-region of the pre-whorls pedicel-bracts anatomic zone. Permutation further yielded an inter-zonal pericladial stalk (PCL). It continued at the floral whorls zone: the calyx (Cl), corolla (Crla), androecium (Andr), and gynoecium (Gynec) with components therein. These organ regions present a continuum as an axial dynamic vector space £Taxi of floral permutation dominated by axial expansion (AE) so that an anatomic sequence of permutation activity runs from the bracts (Bt) region to the carpel (Crpl) inclusive with components therein, summarized by the formula:stamen fltnAndr spiralCrpl ±(Crpl web ± VASCARP ± Crpl diadn ± Crpl fltn ± [fltn no] ± Crpl Rtn)= Tx. The flower reverts from a system of determinate growth to one of indeterminate growth.
Lost dollars threaten research in public academic health centers
Authors: Bourne Henry R. , Vermillion Eric 
Published: August 2016

AbstractDecreasing federal and state support threaten long-term sustainability of research in publicly supported academic health centers. In weathering these financial threats, research at the University of California, San Francisco (UCSF) has undergone three substantial changes: (i) institutional salary support goes preferentially to senior faculty, while the young increasingly depend on grants; (ii) private and government support for research grows apace in clinical departments, but slowly declines in basic science departments; and (iii) research is judged more on its quantity (numbers of investigators and federal and private dollars) than on its goals, achievements, or scientific quality. We propose measures to alleviate these problems. Other large public academic health centers probably confront similar issues, but—except for UCSF—such centers have not been subjected to detailed public analysis.
Architecture of a minimal signalling pathway explains the T cell response to a 1,000,000-fold variation in antigen affinity and dose
Authors: Lever Melissa , Lim Hong-Sheng , Kruger Philipp , Nguyen John , Trendel Nicola , Abu-Shah Enas , Maini Philip K. , van der Merwe P. Anton , Dushek Omer 
Published: August 2016

AbstractT cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map pMHC affinity onto T cell responses have produced inconsistent patterns of responses preventing formulations of canonical models of T cell signalling. Here, a systematic analysis of T cell responses to 1,000,000-fold variations in both pMHC affinity and dose produced bell-shaped dose-response curves and different optimal pMHC affinities at different pMHC doses. Using sequential model rejection/identification algorithms, we identified a unique, minimal model of cellular signalling incorporating kinetic proofreading with limited signalling coupled to an incoherent feed forward loop (KPL-IFF), that reproduces these observations. We show that the KPL-IFF model correctly predicts the T cell response to antigen co-presentation. Our work offers a general approach for studying cellular signalling that does not require full details of biochemical pathways.Significance statementT cells initiate and regulate adaptive immune responses when their T cell antigen receptors recognise antigens. The T cell response is known to depend on the antigen affinity/dose but the precise relationship, and the mechanisms underlying it, are debated. To resolve the debate, we stimulated T cells with antigens spanning a 1,000,000-fold range in affinity/dose. We found that a different antigen (and hence different affinity) produced the largest T cell response at different doses. Using model identification algorithms, we report a simple mechanistic model that can predict the T cell response from the physiological low affinity regime into the high affinity regime applicable to therapeutic receptors.
Conspecific sperm precedence is reinforced but sexual selection weakened in sympatric populations ofDrosophila
Authors: Castillo Dean M. , Moyle Leonie C. 
Published: August 2016

SUMMARYSexual selection is well recognized as a driver of reproductive isolation between lineages. However, selection for increased reproductive isolation could reciprocally change the outcomes of sexual selection, when these processes share a genetic basis. Direct selection for reproductive isolation occurs in the context of ‘reinforcement’, where selection acts to increase prezygotic barriers to reduce the cost of heterospecific matings. Many studies of reinforcement focus on premating reproductive barriers, however postmating traits-such as conspecific sperm precedence (CSP)-can also respond to reinforcing selection. We tested whether i) CSP responded to reinforcing selection, and ii) this response in sympatric populations altered intraspecific sperm competition (ISC) and the strength of sexual selection, with the sister speciesDrosophila pseudoobscuraandD. persimilis. We used sperm competition experiments to evaluate differences in CSP and ISC between two sympatric and two allopatric populations ofD. pseudoobscura. Using multiple genotypes for each population allowed us to estimate not only patterns of phenotype divergence, but also the opportunity for sexual selection within each population. Consistent with a pattern of reinforcement, the sympatric populations had higher mean CSP. Moreover, ISC was altered in sympatric populations, where we observed decreased average offensive sperm competitive ability against conspecific males, allowing less opportunity for sexual selection to operate within these populations. These data demonstrate that strong reinforcing selection for reproductive isolation can have consequences for sexual selection and sexual interactions within species, in these important postmating sperm competition traits.
Evolution of Drift Robustness in Small Populations
Authors: LaBar Thomas , Adami Christoph 
Published: August 2016

AbstractMost mutations are deleterious and cause a reduction in population fitness known as the mutational load. In small populations, weakened selection against slightly-deleterious mutations results in an additional fitness reduction. Many studies have established that populations can evolve a reduced mutational load by evolving mutational robustness, but it is uncertain whether small populations can evolve a reduced susceptibility to drift-related fitness declines. Here, using mathematical modeling and digital experimental evolution, we show that small populations do evolve a reduced vulnerability to drift, or “drift robustness”. We find that, compared to genotypes from large populations, genotypes from small populations have a decreased likelihood of small-effect deleterious mutations, thus causing small-population genotypes to be drift-robust. We further show that drift robustness is not adaptive, but instead arises because small populations preferentially adapt to drift-robust fitness peaks. These results have implications for genome evolution in organisms with small population sizes.
Rules and mechanisms for efficient two-stage learning in neural circuits
Authors: Teşileanu Tiberiu , Ölveczky Bence , Balasubramanian Vijay 
Published: August 2016

AbstractTrial-and-error learning requires evaluating variable actions and reinforcing successful variants. In songbirds, vocal exploration is induced by LMAN, the output of a basal ganglia-circuit that also contributes a corrective bias to the vocal output. This bias is gradually consolidated in RA, a motor cortex analogue downstream of LMAN. We develop a new model of such two-stage learning. Using stochastic gradient descent, we derive how the activity in ‘tutor’ circuits (e.g., LMAN) should match plasticity mechanisms in ‘student’ circuits(e.g.,RA) to achieve efficient learning. We further describe a reinforcement learning framework through which the tutor can build its teaching signal. We show that mismatches between the tutor signal and the plasticity mechanism can impair learning. Applied to birdsong, our results predict the temporal structure of the corrective bias from LMAN given a plasticity rule in RA. Our framework can be applied predictively to other paired brain areas showing two-stage learning.
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
Authors: Nordenfelt Pontus , Moore Travis I. , Mehta Shalin B. , Kalappurakkal Joseph Mathew , Swaminathan Vinay , Koga Nobuyasu , Lambert Talley J. , Baker David , Waters Jennifer C. , Oldenbourg Rudolf , Tani Tomomi , Mayor Satyajit , Waterman Clare M. , Springer Timothy A. 
Published: August 2016

AbstractIntegrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin head, known from crystal structures, adopts a specific orientation dictated by the direction of actin flow on the surface of migrating cells. We insert GFP into the rigid head of the full integrin, model with Rosetta the orientation of GFP and its transition dipole relative to the integrin, and measure orientation with fluorescence polarization microscopy. Dependent on coupling to the cytoskeleton, integrins orient in the same direction as retrograde actin flow with their cytoskeleton-binding β-subunits tilted by applied force. The measurements demonstrate that intracellular forces can orient cell surface integrins and support a molecular model of integrin activation by cytoskeletal force. We have developed a method that places atomic, ~Å structures of cell surface receptors in the context of functional, cellular length-scale, ~μm measurements and shows that rotation and tilt of cell surface receptors relative to the membrane plane can be restrained by interactions with other cellular components.
The dynamic models of consumers’ symbolic needs: in the context of restaurant brands
Authors: Han Sung Ho , Nguyen Bang , Simkin Lyndon 
Published: August 2016

Purpose
The purpose of this paper is to investigate the dynamic process and the meaning of symbolic consumption according to the three symbolic needs (i.e. status needs, social needs, status and social needs) to understand how symbolic messages are conveyed when consumers choose a brand.

Design/methodology/approach
This paper develops three dynamic models, categorized according to the consumers’ needs. The conceptual framework consists of the six constructs: collectivism/individualism, brand reputation, self-congruence, brand affect, brand identification and brand loyalty. Twelve hypotheses were developed and tested. Data were collected from consumers who had experienced well-known global chain restaurant brands. The three models were tested using confirmatory factor analysis and structural equation modelling.

Findings
Findings highlight the important mediating role of brand affect in symbolic consumption, which previously has not been revealed empirically. Moreover, it is found that self-congruence does not mediate the relationship between brand reputation, collectivism/individualism and brand affect, despite its prominence in previous symbolic consumption studies. In the status and social needs models, brand reputation mediates between collectivism/individualism and self-congruence, brand identification, brand affect and brand loyalty.

Originality/value
This is the first empirical paper to investigate symbolic consumption in the context of three types of models, according to symbolic needs, in the context of restaurant consumption. The study also identifies the major components of the consumer’s symbolic needs based on the attributes of symbolic consumption. Moreover, this study reveals that when both social needs and status needs are mixed, a hierarchy exists between consumers’ symbolic needs. Finally, the study makes an important contribution to the literature by applying the concept of brand affect to symbolic consumption research and exploring the relationships between the external motivational factors and the internal elements of symbolic consumption.
Sociocultural brand revitalization
Authors: Närvänen Elina , Goulding Christina 
Published: August 2016

PurposeThe purpose of the paper is to build a sociocultural perspective of brand revitalization. Maintaining brands and bringing them back to life in the market has received much less interest than their creation. Moreover, the existing literature is dominated by the marketing management paradigm where the company’s role is emphasized. This paper addresses the phenomenon of brand revitalization from a sociocultural perspective and examines the role of consumer collectives in the process.Design/methodology/approachUsing a data-driven approach, the study builds on the case of a consumer brand of footwear that has risen to unprecedented popularity without traditional marketing campaigns. Data were generated using an inductive theory building approach utilizing multiple methods, including interviews, participant observation and cultural materials.FindingsThe paper presents a conceptual model of cultural brand revitalization that has four stages: sleeping brand, spontaneous appropriation, diffusion and convergence.Practical implicationsImplications for companies in consumer markets are discussed, suggesting ways to facilitate the process of sociocultural brand revitalization.Originality/valueThe paper contributes to the literature first by offering a sociocultural brand revitalization scenario that highlights the interplay between the actions of consumers and the company, second, by examining the interaction between the symbolic meanings associated with the brand and the practices used by consumers and, third, by offering insights into the relevance of national identity in creating brand meaning.