bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: The First Enantioselective Organocatalytic Synthesis of 3‐Spiro‐α‐alkylidene‐γ‐butyrolactone Oxindoles.
Authors: Cerisoli Lucia , Lombardo Marco , Trombini Claudio , Quintavalla Arianna 
Published: July 2016

Abstractβ‐Nitro oxindoles react with a broad range of alkyl as well as alkenyl and aryl aldehydes to form the title products which are isolated with moderate to high diastereoselectivity and high enantioselectivity in favor of the (Z)‐isomer.
ChemInform Abstract: La(OTf)3‐Catalyzed, Three‐Component Synthesis of Spiro[Indolo‐3,10′‐indeno[1,2‐b]quinolin]‐2,4,11′‐triones in PEG‐400 under Conventional Heating and Ultrasonic Irradiation.
Authors: Kumari Sudesh , Rajeswari M. , Khurana J. M. 
Published: July 2016

AbstractAn efficient and environmentally benign approach for the synthesis of the title triones by one‐pot, three‐component condensation of indandione, isatins, and enaminones is developed.
ChemInform Abstract: Biomimetic Epoxidation in Aqueous Media Catalyzed by Cyclic Dipeptides.
Authors: Berube Christopher , Voyer Normand 
Published: July 2016

AbstractThe enantioselective organocatalyzed epoxidation of α,β‐unsaturated ketones by 2,5‐diketopiperazines in aqueous media is reported.
ChemInform Abstract: Synthesis of Furans and Pyrroles from 2‐Alkoxy‐2,3‐dihydrofurans Through a Nucleophilic Substitution‐Triggered Heteroaromatization.
Authors: Liu Changhui , Zhou Li , Huang Wenbo , Wang Man , Gu Yanlong 
Published: July 2016

Abstract2‐Butoxy‐substituted‐2,3‐dihydrofurans and a variety of carbon nucleophiles offer a diverse synthesis of furans, pyrroles, and dihydrothiophenes in the presence of a Cu‐ or Fe‐catalyst.
ChemInform Abstract: Oxidative Cyclization of 1,5‐Dienes with Hydrogen Peroxide Catalyzed by an Osmium(III) Complex: Synthesis of cis‐Tetrahydrofurans.
Authors: Sugimoto Hideki , Kanetake Takayuki , Maeda Kazuki , Itoh Shinobu 
Published: July 2016

AbstractThe cyclization proceeds with high stereoselectivity to afford cis‐tetrahydrofurans in low yields.
ChemInform Abstract: Dual Catalysis: Proton/Metal‐Catalyzed Tandem Benzofuran Annulation/Carbene Transfer Reaction.
Authors: Ma Jun , Chen Kai , Fu Hongguang , Zhang Li , Wu Wanqing , Jiang Huanfeng , Zhu Shifa 
Published: July 2016

Abstracto‐Hydroxyl‐benzylalcohols bearing an acetylenic amine side chain are subjected to conditions A).
ChemInform Abstract: A Calcium Catalyzed Regioselective (5‐exo Dig) Tandem Process for the Synthesis of Fully Substituted Furans.
Authors: Yaragorla Srinivasarao , Dada Ravikrishna , Pareek Abhishek , Singh Garima 
Published: July 2016

AbstractFused furans are prepared from alkynols and coumarins or cyclohexanediones via cascade reaction involving alkylation, 5‐exo dig cyclization, and isomerization.
ChemInform Abstract: Palladium(II)‐Catalyzed Synthesis of Dibenzothiophene Derivatives via the Cleavage of Carbon—Sulfur and Carbon—Hydrogen Bonds.
Authors: Tobisu Mamoru , Masuya Yoshihiro , Baba Katsuaki , Chatani Naoto 
Published: July 2016

AbstractThe title reaction is mechanistically uncommon because the product forming step is the oxidative addition instead of reductive elimination.
ChemInform Abstract: Synthesis of Benzo[c]thiophenes by Rhodium(III)‐Catalyzed Dehydrogenative Annulation.
Authors: Fukuzumi Keita , Unoh Yuto , Nishii Yuji , Satoh Tetsuya , Hirano Koji , Miura Masahiro 
Published: July 2016

AbstractSome of the annulated thiophene derivatives show strong solid‐state fluorescence.
ChemInform Abstract: Ligand‐Enabled γ‐C(sp3)—H Olefination of Amines: En route to Pyrrolidines.
Authors: Jiang Heng , He Jian , Liu Tao , Yu Jin‐Quan 
Published: July 2016

AbstractThese reactions proceed by Pd‐catalyzed amine olefinations followed by aza‐Wacker oxidative cyclization or conjugate addition.
ChemInform Abstract: Ligand‐Free Pd‐Catalyzed Domino Synthesis of Carbazoles via Dehydrogenative Aromatization/C(sp2)—C(sp2) Coupling Sequence.
Authors: Wen Lixian , Tang Lin , Yang Yu , Zha Zhenggen , Wang Zhiyong 
Published: July 2016

AbstractThe protocol works in the absence of a ligand and can be applied to a series of anilines and cyclohexanones.
ChemInform Abstract: Ruthenium(II)‐Catalyzed Synthesis of Pyrrole‐ and Indole‐Fused Isocoumarins by C—H Bond Activation in DMF and Water.
Authors: Singh Keisham S. , Sawant Sneha G. , Dixneuf Pierre H. 
Published: July 2016

AbstractThe title reaction uses pyrrole‐2‐carboxylic acids and indole‐3‐carboxylic acids as starting material and copper acetate as oxidant.
ChemInform Abstract: Bi‐ and Trinuclear Copper(I) Complexes of 1,2,3‐Triazole‐tethered NHC Ligands: Synthesis, Structure, and Catalytic Properties.
Authors: Gu Shaojin , Du Jiehao , Huang Jingjing , Xia Huan , Yang Ling , Xu Weilin , Lu Chunxin 
Published: July 2016

AbstractThe title complexes are prepared via reaction of imidazolium salt ligands with copper powder.
ChemInform Abstract: I2‐Catalyzed Oxidative Coupling Reactions of Hydrazones and Amines and the Application in the Synthesis of 1,3,5‐Trisubstituted 1,2,4‐Triazoles.
Authors: Chen Zhengkai , Li Hongli , Dong Weipeng , Miao Maozhong , Ren Hongjun 
Published: July 2016

AbstractThe metal‐free rapid procedure renders possible the synthesis of a broad spectrum of structurally diverse title compounds (mechanism).
ChemInform Abstract: Urea Assisted Copper(I)‐Catalyzed Azide—Alkyne Cycloaddition Reactions in Water.
Authors: Ali Abdul Aziz , Chetia Mitali , Sarma Diganta 
Published: July 2016

AbstractThe novel three‐component catalyst system allows the highly efficient and regioselective synthesis of 1,4‐disubstituted triazoles.
ChemInform Abstract: Synthesis of N1 and N2 Coumarin Substituted 1,2,3‐Triazole Isomers via Click Chemistry Approach
Authors: Shamala Devadas , Shivashankar Kalegowda , Chandra Kalegowda , Mahendra Madegowda 
Published: July 2016

Abstractfrom terminal alkynes, sodium azide, and bromomethylcoumarins
ChemInform Abstract: Benzyltrimethylammoniumfluoride Hydrate: An Efficient Catalyst for One‐Pot Synthesis of Hantzsch 1,4‐Dihydropyridines and Their Aromatization.
Authors: Khaskel Anamika , Barman Pranjit 
Published: July 2016

AbstractA simple and cost‐effective approach for the synthesis of Hantzsch 1,4‐dihydropyridines under solvent‐free reaction conditions and a new method for their efficient oxidation are developed.
ChemInform Abstract: Graphene Oxide: A Reusable and Metal‐Free Carbocatalyst for the One‐Pot Synthesis of 2‐Amino‐3‐cyanopyridines in Water.
Authors: Khalili Dariush 
Published: July 2016

AbstractThe facile one‐pot protocol allows the synthesis of the title compounds via four‐component condensation of ketones, aldehydes, malononitrile, and ammonium acetate.
ChemInform Abstract: Ultrasound Mediated, Green Innovation for the Synthesis of Polysubstituted 1,4‐Dihydropyridines.
Authors: Tabassum Sumaiya , Govindaraju Santhosh , Khan Riyaz‐ur‐Rahaman , Pasha M. A. 
Published: July 2016

AbstractA series of novel polysubstituted 1,4‐dihydropyridines is synthesized via a one‐pot four‐component cyclocondensation reaction of aromatic aldehydes, malononitrile, acetylenedicarboxylates, and arylamines catalyzed by copper(I) iodide in aqueous medium under ultrasound irradiation.
ChemInform Abstract: Deep Eutectic Solvent Mediated Synthesis of Quinazolinones and Dihydroquinazolinones: Synthesis of Natural Products and Drugs.
Authors: Ghosh Suman Kr , Nagarajan Rajagopal 
Published: July 2016

AbstractThe title compounds are prepared by mild and green deep eutectic solvent mediated cyclization of substituted or unsubstituted anthranilamides with a wide range of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields.
ChemInform Abstract: Synthesis of 5,5′‐(Ethane‐1,2‐diyl)bis(3‐( (5‐bromo‐6‐methyl‐2‐tertiaryaminopyrimidin‐4‐yl)thio) ‐4H‐1,2,4‐triazol‐4‐amines) and Their Novel Bis‐Cyclized Products, 1,2‐Bis(pyrimido[5,4e][1,2,4] triazolo[3,4‐b][1,3,4]thiadiazin‐3‐yl)ethane, as Potential Inhibitors of 15‐Lipoxygenase.
Authors: Asghari Tayebe , Bakavoli Mehdi , Eshghi Hossein , Saberi Sattar , Ebrahimpour Zahra 
Published: July 2016

AbstractAll new compounds are evaluated in vitro as potential inhibitors of 15‐lipoxygenase (15‐LO).
ChemInform Abstract: Co(III)‐Catalyzed Synthesis of Quinazolines via C—H Activation of N‐Sulfinylimines and Benzimidates.
Authors: Wang Fen , Wang He , Wang Qiang , Yu Songjie , Li Xingwei 
Published: July 2016

AbstractBoth classes of title compounds are treated with dioxazolones as nitrile synthons since nitriles themselves fail to act as coupling partners in the synthesis.
ChemInform Abstract: Synthesis and Antitumor Activity Evaluation of Novel Substituted 5H‐Benzo[i][1,3,4]thiadiazolo[3,2‐a]quinazoline‐6,7‐diones.
Authors: Wu Liqiang , Zhang Chong 
Published: July 2016

AbstractThe title compounds are prepared by one‐pot condensation of hydroxynaphthoquinone, aldehydes, and aminothiadiazoles in moderate yields.
ChemInform Abstract: Synthesis and Biological Activity of Novel Ethyl Esters of 4‐R‐6,8‐Dimethyl‐1‐oxo‐1,2‐dyhidropyrrolo[1,2‐d] [1,2,4]triazine‐7‐carboxylic Acids.
Authors: Astakhina Valeriia , Voievudskyi Maxim , Kharchenko Olexander , Novikov Vladimir , Komarovska‐Porohnyavets Elena , Petukhova Olena 
Published: July 2016

AbstractCompounds (III) and (VIIId,g,i) show weak in vitro anticancer activities against leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancer cell lines.
ChemInform Abstract: A Cascade Phosphinoylation/Cyclization/Desulfonylation Process for the Synthesis of 3‐Phosphinoylindoles.
Authors: Gao Yuzhen , Lu Guozhang , Zhang Pengbo , Zhang Liangliang , Tang Guo , Zhao Yufen 
Published: July 2016

AbstractA wide range of substrates can be used for this operationally simple cascade annulation process to give 3‐phosphinoylindoles.
ChemInform Abstract: Phosphorothiolation of Aryl Boronic Acids Using P(O)H Compounds and Elemental Sulfur.
Authors: Xu Jian , Zhang Liangliang , Li Xueqin , Gao Yuzhen , Tang Guo , Zhao Yufen 
Published: July 2016

AbstractBoth ‐P(O)‐H and ‐P(S)‐H reactants can be used with success to afford a large variety of biologically interesting phosphorothioates and posphorodithioates in one step.
ChemInform Abstract: Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010.
Authors: Liu Zhaoming , Chen Yan , Chen Senhua , Liu Yayue , Lu Yongjun , Chen Dongni , Lin Yongcheng , Huang Xishan , She Zhigang 
Published: July 2016

AbstractThe title compounds (Ia) and (Ib) possess a novel carbocyclic skeleton, represented by an unprecedented ring system.
ChemInform Abstract: New Antimalarial Norterpene Cyclic Peroxides from Xisha Islands Sponge Diacarnus megaspinorhabdosa.
Authors: Song Shao‐Jiang , et al.  
Published: July 2016

AbstractFour new norterpene cyclic peroxides diacarnuperoxide M (Ia), diacarnuperoxide N (Ib), (+)‐2,3,6‐epihurghaperoxide (IIa), and (+)‐2,3,6‐epihurghaperoxide acid (IIb) are isolated from Xisha islands sponge Diacarnus megaspinorhabdosa together with three known norterpene cyclic peroxides.
ChemInform Abstract: Stereoselective Synthesis of Protected L‐ and D‐Dideoxysugars and Analogues via Prins Cyclizations.
Authors: Beattie Ryan J. , Hornsby Thomas W. , Craig Gemma , Galan M. Carmen , Willis Christine L. 
Published: July 2016

AbstractThe title synthesis from a novel and robust silicon‐acetal (II) and homoallylic alcohols [e.g. (I)] features high yields and excellent stereocontrol.
ChemInform Abstract: Reaction of Glyconitriles with Organometallic Reagents: Access to Acyl β‐C‐Glycosides.
Authors: Guisot Nicolas E. S. , Ella Obame Idriss , Ireddy Prathap , Nourry Arnaud , Saluzzo Christine , Dujardin Gilles , Dubreuil Didier , Pipelier Muriel , Guillarme Stephane 
Published: July 2016

AbstractThe formation of undesired glycals in this reaction is prevented by utilization of a free hydroxy group in position 2, which is deprotonated during the process.
ChemInform Abstract: Daldionin, an Unprecedented Binaphthyl Derivative, and Diverse Polyketide Congeners from a Fungal Orchid Endophyte.
Authors: Barnes Emma C. , Jumpathong Juangjun , Lumyong Saisamorn , Voigt Kerstin , Hertweck Christian 
Published: July 2016

AbstractA series of constituents is isolated from the title species.
ChemInform Abstract: Long‐Chain Alkyl‐Substituted Gentisic Acid and Benzoquinone Derivatives from the Root of Micronychia tsiramiramy (Anacardiaceae).
Authors: Sewald Norbert , et al.  
Published: July 2016

AbstractTwo new compounds named micronyc acid (I) and micronone (II) are isolated together with four known compounds.
ChemInform Abstract: Bioactive Lignan Constituents from the Twigs of Sambucus williamsii.
Authors: Suh Won Se , Subedi Lalita , Kim Sun Yeou , Choi Sang Un , Lee Kang Ro 
Published: July 2016

AbstractThree new lignan derivatives, sambucasinol A (I), sambucasinol B (II), and sambucasinol C (III), are isolated from the twigs of Sambucus williamsii together with 7 known compounds.
ChemInform Abstract: Analysis of the Magnetocaloric Effect in Powder Samples Obtained by Ball Milling
Authors: Blazquez J. S. , Ipus J. J. , Moreno‐Ramirez L. M. , Borrego J. M. , Lozano‐Perez S. , Franco V. , Conde C. F. , Conde A. 
Published: July 2016

AbstractReview: 59 refs.
ChemInform Abstract: Alkaloids and Isoprenoids Modification by Copper(I)‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition (Click Chemistry): Toward New Functions and Molecular Architectures
Authors: Kacprzak Karol , Skiera Iwona , Piasecka Monika , Paryzek Zdzislaw 
Published: July 2016

AbstractReview: 244 refs.
ChemInform Abstract: Oxime‐Derived Palladacycles: Applications in Catalysis
Authors: Najera Carmen 
Published: July 2016

AbstractReview: catalytic activity of oxime‐derived palladacycles for alkenylation, cross‐coupling, alkynylation, carbonylation, annulation, α‐arylation, C—H activation, and oxime rearrangement reactions as well as their role as metalloenzymes in hydrolytic processes along with other applications in organic synthesis; 117 refs.
ChemInform Abstract: αvβ3‐ or α5β1‐Integrin‐Selective Peptidomimetics for Surface Coating
Authors: Mas‐Moruno Carlos , Fraioli Roberta , Rechenmacher Florian , Neubauer Stefanie , Kapp Tobias G. , Kessler Horst 
Published: July 2016

AbstractReview: 137 refs + subrefs.
ChemInform Abstract: An Overview of Detection Techniques for Monitoring Dioxin‐Like Compounds: Latest Technique Trends and Their Applications
Authors: Tavakoly Sany Seyedeh Belin , Narimani Leila , Soltanian Faezeh Khalifeh , Hashim Rosli , Rezayi Majid , Karlen David J. , Mahmud H. N. M. Ekramul 
Published: July 2016

AbstractReview: 117 refs.
Sleep quality and its association with fatigue, symptom burden, and mood in patients with advanced cancer in a clinic for early‐phase oncology clinical trials
Authors: George Goldy C. , Iwuanyanwu Eucharia C. , Anderson Karen O. , Yusuf Alizeh , Zinner Ralph G. , Piha‐Paul Sarina A. , Tsimberidou Apostolia M. , Naing Aung , Fu Siqing , Janku Filip , Subbiah Vivek , Cleeland Charles S. , Mendoza Tito R. , Hong David S. 
Published: July 2016

BACKGROUNDLimited data exist about sleep quality for patients with advanced cancer in phase 1 clinical trials. Poor sleep quality is often not captured as an adverse event, and its association with fatigue, one of the most frequently reported adverse events, is not documented routinely. This article describes sleep quality and its relation with fatigue, symptom burden, and mood in patients recruited from an early‐phase clinic for targeted therapy.METHODSSleep, fatigue, symptom burden, and mood were assessed with the Pittsburgh Sleep Quality Index (PSQI), the Brief Fatigue Inventory, the MD Anderson Symptom Inventory (MDASI), and the Brief Profile of Mood States, respectively; the Eastern Cooperative Oncology Group (ECOG) performance status (PS) was determined from medical records.RESULTSThe sample (n = 256) was 51.2% female, 90% had an ECOG PS of 0 or 1, and the mean age was 58 ± 0.8 years. Poor sleepers (global PSQI score > 5) constituted 64% of the sample. In separate multiple regression models, poor sleepers had higher levels of fatigue (P < .001), symptom burden (P < .001), and overall mood disturbance (P < .001) than good sleepers. Also, compared with good sleepers, poor sleepers had greater fatigue‐related and symptom‐related interference with daily activities (all P values < .001). The MDASI disturbed‐sleep item correlated well with the global PSQI score (Pearson's r = 0.679, P < .001), and this suggests its usefulness as a patient‐reported outcome screener of sleep quality in early‐phase clinical trials clinics.CONCLUSIONSPoor sleep quality was a significant problem in the current study and was associated with greater fatigue, symptom burden, and mood disturbance. Sleep quality should be routinely assessed in patients with advanced cancer who are participating in early‐phase clinical trials. Cancer 2016;122:3401–3409. © 2016 American Cancer Society.
Impact of optimization algorithms on hybrid indoor positioning based on GSM and Wi‐Fi signals
Authors: Machaj Juraj , Brida Peter 
Published: July 2016

SummaryIn the recent time indoor positioning becomes an extremely hot topic between researchers worldwide. This is mainly because of lack of available positioning solutions in the indoor environment and possibility to offer novel services based on location of users. Such services can also open new markets for service providers and thus increase their income. In this paper we will focus on application of optimization algorithms on performance of hybrid indoor positioning system, which utilize radio signals from both Global System for Mobile communication and Wi‐Fi networks simultaneously. The system is based on fingerprinting framework, which is widely used for indoor positioning because of its performance in strong multipath environment. Tests of the optimization algorithms were performed via simulations that were performed using simulation model created in Matlab environment. Copyright © 2016 John Wiley & Sons, Ltd.
Genetic diversity and structuring across the range of a widely distributed ladybird: focus on rear‐edge populations phenotypically divergent
Authors: Lecompte Émilie , Bouanani Mohand‐Ameziane , Magro Alexandra , Crouau‐Roy Brigitte 
Published: July 2016

AbstractPopulation genetics and phenotypic structures are often predicted to vary along the geographic range of a species. This phenomenon would be accentuated for species with large range areas, with discontinuities and marginal populations. We herein compare the genetic patterns of central populations of Coccinella septempunctata L. with those of two phenotypically differentiated populations considered as rear‐edge populations and subspecies based on phenotype (Algeria and Japan). According to the central‐marginal model and expected characteristics of rear‐edge populations, we hypothesize that these rear‐edge populations have (1) a reduced genetic diversity, resulting from their relative isolation over long periods of time, (2) a higher population genetic differentiation, explained by low contemporary gene flow levels, and (3) a relationship between genetic diversity characteristics and phenotypes, due to historical isolation and/or local adaptation. Based on genotyping of 28 populations for 18 microsatellite markers, several levels of regional genetic diversity and differentiation are observed between and within populations, according to their localization: low within‐population genetic diversity and higher genetic differentiation of rear‐edge populations. The genetic structuring clearly dissociates the Algerian and Eastern Asia populations from the others. Geographical patterns of genetic diversity and differentiation support the hypothesis of the central‐marginal model. The pattern observed is in agreement with the phenotypic structure across species range. A clear genetic break between populations of Algeria, the Eastern Asia, and the remaining populations is a dominant feature of the data. Differential local adaptations, absence of gene flow between marginal and central populations, and/or incapacity to mate after colonization, have contributed to their distinct genotypic and phenotypic characteristics.
Combinatorial Optimization Method Based on Hierarchical Structure in Solution Space
Authors: OCHIAI HIROKI , KANAZAWA TAKAHIKO , TAMURA KENICHI , YASUDA KEIICHIRO 
Published: July 2016

SUMMARYIn this paper, we introduce a new concept of hierarchical structure into solution space of a combinatorial optimization problem, and develop a novel combinatorial optimization method based on the concept. The introduction of the above new hierarchical structure concept “basin of attraction,” which is a set binding solution by utilizing properties of local optimal solutions, enables us to construe solution space as not only set of solutions but also set of basins of attraction hierarchically. It is well known that the appropriate balance of two policies, intensification and diversification, is essential in the search of metaheuristics. The proposed method clarifies the search policy by relating the hierarchical structure in solution space with intensification and diversification. With regard to diversification, we incorporate a movement strategy that has longer term or more macroscopic viewpoint than before in the algorithm by utilizing the concept basin of attraction. The performance of the proposed combinatorial optimization method is inspected by numerical experiments using some typical benchmark problems of a traveling salesman problem, a knapsack problem, a flow‐shop scheduling problem, and a quadratic assignment problem.
Holocene delta evolution and sediment flux of the Pearl River, southern China
Authors: Wei Xing , Wu Chaoyu , Ni Peitong , Mo Wenyuan 
Published: July 2016

ABSTRACTDelta progradation and sediment flux of the Pearl River Delta (PRD), southern China, during the Holocene are presented based on analyses of borehole data on the delta plain. Results indicate that the delta prograded into the drowned valley because of early Holocene inundation from 9 to 6 cal ka BP, as sea‐level rise decelerated. The sea level reached its present level at about 6 cal ka BP and, as a consequence, a large portion of the drowned valley was covered by the estuary, with more than 160 rock islands and platforms. The scattered landmasses promoted active deposition and acted as deposition nuclei during deltaic evolution. Consequently, apart from exhibiting a general tendency towards progression, PRD development occurred less regularly over time and space because of deposition around island boundaries. During the last 2 ka, mainly because of significantly increased human activities, which have trapped sediments in the encircled tidal flats along the front of delta plains, the shoreline has advanced rapidly. Estimated sediment fluxes for the three periods (9–6, 6–2 and 2–0 cal ka BP), based on the sediment volume analysis, were 17–25, 22–30 and 44–58 million t a−1, respectively.