bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries
Authors: Kwasny Caroline , Manuwald Ulf , Kugler Joachim , Rothe Ulrike 
Published: November 2017

AbstractThe objectives of this systematic review were to estimate the incidence, prevalence and natural history of the metabolic (vascular) syndrome (MVS) among adults in different European countries. Furthermore, we assessed its co-incidence with type 2 diabetes (T2DM) and cardiovascular diseases (CVD). PubMed, MedLine, and EMBASE (via Ovid) were searched for relevant studies. After reading 116 full-text articles to find eligible ones, 66 publications met our inclusion criteria. Data for the incidence are based on a study from Portugal, in which the incidence rate for the MVS was 47.2/1000 person-years. Prevalence varied strongly depending on country and definition. The lowest was found in the United Kingdom (3%), the highest in Finland (71.7%). No article that deals with the natural history of the MVS was found. Considering the co-existence of MVS and T2DM, it ranged between 2% (United Kingdom) and 74.4% (Spain). The co-occurrence of MVS and CVD ranged from 2.8% (Italy) up to 52% (Netherlands). Coronary heart disease (CHD) varied between 1.2% and 44.2%. With regard to peripheral artery disease (PAD), values between 3.3% and 59.8% were found. Due to the many different definitions of the MVS, a comparison is very difficult. Overall prevalence ranged between 3% and 71.7% depending on definition, age, and country. An association between MVS and T2DM as well as several CVD can be assumed.
Using deep learning and Google Street View to estimate the demographic makeup of neighborhoods across the United States
Authors: Gebru Timnit , Krause Jonathan , Wang Yilun , Chen Duyun , Deng Jia , Aiden Erez Lieberman , Fei-Fei Li 
Published: November 2017

SignificanceWe show that socioeconomic attributes such as income, race, education, and voting patterns can be inferred from cars detected in Google Street View images using deep learning. Our model works by discovering associations between cars and people. For example, if the number of sedans in a city is higher than the number of pickup trucks, that city is likely to vote for a Democrat in the next presidential election (88% chance); if not, then the city is likely to vote for a Republican (82% chance).
Equilibration of energy in slow–fast systems
Authors: Shah Kushal , Turaev Dmitry , Gelfreich Vassili , Rom-Kedar Vered 
Published: November 2017

Significance
Do partial energies in slow–fast Hamiltonian systems equilibrate? This is a long-standing problem related to the foundation of statistical mechanics. Altering the traditional ergodic assumption, we propose that nonergodicity in the fast subsystem leads to equilibration of the whole system. To show this principle, we introduce a set of mechanical toy models—the springy billiards—and describe stochastic processes corresponding to their adiabatic behavior. We expect that these models and this principle will play an important role in the quest to establish and study the underlying postulates of statistical mechanics, one of the long-standing scientific grails.
Inequality in nature and society
Authors: Scheffer Marten , van Bavel Bas , van de Leemput Ingrid A. , van Nes Egbert H. 
Published: November 2017

Significance
Inequality is one of the main drivers of social tension. We show striking similarities between patterns of inequality between species abundances in nature and wealth in society. We demonstrate that in the absence of equalizing forces, such large inequality will arise from chance alone. While natural enemies have an equalizing effect in nature, inequality in societies can be suppressed by wealth-equalizing institutions. However, over the past millennium, such institutions have been weakened during periods of societal upscaling. Our analysis suggests that due to the very same mathematical principle that rules natural communities (indeed, a “law of nature”) extreme wealth inequality is inevitable in a globalizing world unless effective wealth-equalizing institutions are installed on a global scale.
Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the
Xenopus
egg
Authors: Presler Marc , Van Itallie Elizabeth , Klein Allon M. , Kunz Ryan , Coughlin Margaret L. , Peshkin Leonid , Gygi Steven P. , Wühr Martin , Kirschner Marc W. 
Published: November 2017

Significance
Protein phosphorylation and degradation drive critical events in early embryogenesis and the cell cycle; however, comprehensive and accurate analysis of these changes is currently difficult. Using a mass-spectrometric approach, we present a quantitative view of the protein and posttranslational economy of the fertilization response in the frog egg. Protein degradation affects a small but very important class of proteins, while regulatory phosphorylation and protein release occur on a far larger scale. We have developed broadly applicable analytical methods for phosphorylation that provide absolute quantification with confidence intervals for improved interpretability of posttranslational modification analysis.
Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks
Authors: Paix Alexandre , Folkmann Andrew , Goldman Daniel H. , Kulaga Heather , Grzelak Michael J. , Rasoloson Dominique , Paidemarry Supriya , Green Rachel , Reed Randall R. , Seydoux Geraldine 
Published: November 2017

Significance
Genome editing, the introduction of precise changes in the genome, is revolutionizing our ability to decode the genome. Here we describe a simple method for genome editing in mammalian cells that takes advantage of an efficient mechanism for gene conversion that utilizes linear donors. We demonstrate that PCR fragments containing edits up to 1 kb require only 35-bp homology sequences to initiate repair of Cas9-induced double-stranded breaks in human cells and mouse embryos. We experimentally determine donor DNA design rules that maximize the recovery of edits without cloning or selection.
Catch bond drives stator mechanosensitivity in the bacterial flagellar motor
Authors: Nord Ashley L , Gachon Emilie , Perez-Carrasco Ruben , Nirody Jasmine A. , Barducci Alessandro , Berry Richard M. , Pedaci Francesco 
Published: November 2017

Significance
The bacterial flagellar motor (BFM) is the rotary motor powering swimming of many motile bacteria. Many of the components of this molecular machine are dynamic, a property which allows the cell to optimize its behavior in accordance with the surrounding environment. A prime example is the stator unit, a membrane-bound ion channel that is responsible for applying torque to the rotor. The stator units are mechanosensitive, with the number of engaged units dependent on the viscous load on the motor. We measure the kinetics of the stators as a function of the viscous load and find that the mechanosensitivity of the BFM is governed by a catch bond: a counterintuitive type of bond that becomes stronger under force.
Contrasting pronominal subjects
Authors: Pisanski Peterlin Agnes , Mikolič Južnič Tamara 
Published: November 2017

Abstract
Pronominal subject use constitutes a potential challenge in translation because of cross-linguistic differences: while the subject must be expressed in non-null subject languages, this is not necessary in null subject languages. The aim of the paper is twofold: first, to show that the type of source language influences the frequency of personal pronouns in translation, and second, to establish whether translations into a null subject language differ from comparable target language originals in terms of pronominal subject use. The study is based on the analysis of a 625,000-word corpus comprising original and translated popular science texts in Slovene and the corresponding source texts in English and Italian. The results confirm that pronominal subjects are more frequent in translations from English, a non-null subject language; furthermore, they are more frequent in translations than in comparable originals. Untypical cohesive patterns are identified in translations and possible reasons for their presence are explored.
Suppressive effect of nobiletin and epicatechin gallate on fructose uptake in human intestinal epithelial Caco-2 cells
Authors: Satsu Hideo , Awara Sohei , Unno Tomonori , Shimizu Makoto 
Published: December 2017

AbstractInhibition of excessive fructose intake in the small intestine could alleviate fructose-induced diseases such as hypertension and non-alcoholic fatty liver disease. We examined the effect of phytochemicals on fructose uptake using human intestinal epithelial-like Caco-2 cells which express the fructose transporter, GLUT5. Among 35 phytochemicals tested, five, including nobiletin and epicatechin gallate (ECg), markedly inhibited fructose uptake. Nobiletin and ECg also inhibited the uptake of glucose but not of L-leucine or Gly-Sar, suggesting an inhibitory effect specific to monosaccharide transporters. Kinetic analysis further suggested that this reduction in fructose uptake was associated with a decrease in the apparent number of cell-surface GLUT5 molecules, and not with a change in the affinity of GLUT5 for fructose. Lastly, nobiletin and ECg suppressed the permeation of fructose across Caco-2 cell monolayers. These findings suggest that nobiletin and ECg are good candidates for preventing diseases caused by excessive fructose intake.
Subcellular localization of aphidicolin biosynthetic enzymes heterologously expressed in Aspergillus oryzae
Authors: Ban Akihiko , Tanaka Mizuki , Fujii Ryuya , Minami Atsushi , Oikawa Hideaki , Shintani Takahiro , Gomi Katsuya 
Published: December 2017

Abstract
The secondary metabolite aphidicolin has previously been produced by Aspergillus oryzae after the heterologous expression of four biosynthetic enzymes isolated from Phoma betae. In this study, we examined the subcellular localization of aphidicolin biosynthetic enzymes in A. oryzae. Fusion of green fluorescent protein to each enzyme showed that geranylgeranyl diphosphate synthase and terpene cyclase are localized to the cytoplasm and the two monooxygenases (PbP450-1 and PbP450-2) are localized to the endoplasmic reticulum (ER). Protease protection assays revealed that the catalytic domain of both PbP450s was cytoplasmic. Deletion of transmembrane domains from both PbP450s resulted in the loss of ER localization. Particularly, a PbP450-1 mutant lacking the transmembrane domain was localized to dot-like structures, but did not colocalize with any known organelle markers. Aphidicolin biosynthesis was nearly abrogated by deletion of the transmembrane domain from PbP450-1. These results suggest that ER localization of PbP450-1 is important for aphidicolin biosynthesis.
An Empirical Study on the Driving Path of Optimizing the Resources Allocation of Foreign Trade Enterprises from the Perspective of Energy Supply-side Reform
Authors: You Yu-cong , Yi Lu-xia 
Published: November 2017

Abstract
From the perspective of energy supply-side reform, this paper, by conducting an empirical study on foreign trade enterprises, conducts a research on the cross-role effect of optimizing the resources allocation and enhancing the energy efficiency. Methodologically, this paper creatively introduces the HILE's probabilistic structured property into Granger causality test analysis, forming an HILE–Granger (H-G) model, so as to empirically estimate both the short-term and long-term causal relationship effects between the energy efficiency and resources allocation. Conclusion is drawn that optimization of resources allocation is positively proportional with the energy efficiency enhancement. This paper is to provide a decision-making reference for the supply side reform strategy of foreign trade enterprises under the background of green energy economy.
Improving delivery routes using combined heuristic and optimization in a consumer goods distribution company
Authors: Wibisono E , Santoso A , Sunaryo M A 
Published: November 2017

Abstract
XYZ is a distributor of various consumer goods products. The company plans its delivery routes daily and in order to obtain route construction in a short amount of time, it simplifies the process by assigning drivers based on geographic regions. This approach results in inefficient use of vehicles leading to imbalance workloads. In this paper, we propose a combined method involving heuristic and optimization to obtain better solutions in acceptable computation time. The heuristic is based on a time-oriented, nearest neighbor (TONN) to form clusters if the number of locations is higher than a certain value. The optimization part uses a mathematical modeling formulation based on vehicle routing problem that considers heterogeneous vehicles, time windows, and fixed costs (HVRPTWF) and is used to solve routing problem in clusters. A case study using data from one month of the company’s operations is analyzed, and data from one day of operations are detailed in this paper. The analysis shows that the proposed method results in 24% cost savings on that month, but it can be as high as 54% in a day.
Relationship Between Interrectus Distance and Symptom Severity in Women With Diastasis Recti Abdominis in the Early Postpartum Period
Authors: Keshwani Nadia , Mathur Sunita , McLean Linda 
Published: December 2017

Abstract

Background
Diastasis recti abdominis (DrA) is associated with negative body image, musculoskeletal pain and dysfunction, and perhaps urogynecological complaints. The severity of DrA has traditionally been determined by measuring the interrectus distance (IRD); however, the relationship between IRD and symptoms in women with DrA is unclear.

Objective
The objective of the study was to investigate the relationship between IRD and symptom severity in women with DrA in the early postpartum period.

Design
This study used a cross-sectional design.

Methods
Thirty-two women with DrA were assessed at 3 weeks postpartum. The IRD was measured using ultrasound imaging. Symptom severity was assessed using the Multidimensional Body-Self Relations Questionnaire subscales (body image), visual analog scales (abdominal, low back, and pelvic pain intensity), the Modified Oswestry Index (disability due to low back pain), and the Pelvic Floor Distress Inventory and Pelvic Floor Impact Questionnaire (urogynecological dysfunction). Spearman correlation coefficients (ρ) between IRD and each outcome were calculated and tested using 1-tailed significance (adjusted α = .009).

Results
The group median IRD was 2.97 cm (interquartile range = 1.65 cm), with the largest IRD in the sample being 7.97 cm. The IRD was significantly correlated with worst abdominal pain in the last 24 hours (ρ = 0.45, P = .005) and with overall body image (ρ = −0.44, P = .006) but not with the other outcomes.

Limitations
Women in the sample were primiparous, were in the early (3 weeks) postpartum period, had relatively low body mass indexes (mean = 25.0 kg/m2) considering that they had recently given birth, were all breast-feeding, and had a narrow age range (27–35 years old). These factors limited the generalizability of our results to all women with DrA.

Conclusions
This preliminary work suggests that, in the early postpartum period, IRD as a measure of DrA severity is meaningful for body image.
Managing Multiplicity: Conceptualizing Physician Cognition in Multipatient Environments
Authors: Chan Teresa M. , Mercuri Mathew , Van Dewark Kenneth , Sherbino Jonathan , Schwartz Alan , Norman Geoff , Lineberry Matthew 
Published: November 2017

PurposeEmergency physicians (EPs) regularly manage multiple patients simultaneously, often making time-sensitive decisions around priorities for multiple patients. Few studies have explored physician cognition in multipatient scenarios. The authors sought to develop a conceptual framework to describe how EPs think in busy, multipatient environments.MethodFrom July 2014 to May 2015, a qualitative study was conducted at McMaster University, using a think-aloud protocol to examine how 10 attending EPs and 10 junior residents made decisions in multipatient environments. Participants engaged in the think-aloud exercise for five different simulated multipatient scenarios. Transcripts from recorded interviews were analyzed inductively, with an iterative process involving two independent coders, and compared between attendings and residents.ResultsThe attending EPs and junior residents used similar processes to prioritize patients in these multipatient scenarios. The think-aloud processes demonstrated a similar process used by almost all participants. The cognitive task of patient prioritization consisted of three components: a brief overview of the entire cohort of patients to determine a general strategy; an individual chart review, whereby the participant created a functional patient story from information available in a file (i.e., vitals, brief clinical history); and creation of a relative priority list. Compared with residents, the attendings were better able to construct deeper and more complex patient stories.ConclusionsThe authors propose a conceptual framework for how EPs prioritize care for multiple patients in complex environments. This study may be useful to teachers who train physicians to function more efficiently in busy clinical environments.
Alphaxalone Binds in Inner Transmembrane β+–α− Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors
Authors: Ziemba Alexis M. , Szabo Andrea , Pierce David W. , Haburcak Marian , Stern Alex T. , Nourmahnad Anahita , Halpin Elizabeth S. , Forman Stuart A. 
Published: November 2017

Abstract

Background
Neurosteroids like alphaxalone are potent anxiolytics, anticonvulsants, amnestics, and sedative-hypnotics, with effects linked to enhancement of γ-aminobutyric acid type A (GABAA) receptor gating in the central nervous system. Data locating neurosteroid binding sites on synaptic αβγ GABAA receptors are sparse and inconsistent. Some evidence points to outer transmembrane β+–α− interfacial pockets, near sites that bind the anesthetics etomidate and propofol. Other evidence suggests that steroids bind more intracellularly in β+–α− interfaces.

Methods
The authors created 12 single-residue β3 cysteine mutations: β3T262C and β3T266C in β3-M2; and β3M283C, β3Y284C, β3M286C, β3G287C, β3F289C, β3V290C, β3F293C, β3L297C, β3E298C, and β3F301C in β3-M3 helices. The authors coexpressed α1 and γ2L with each mutant β3 subunit in Xenopus oocytes and electrophysiologically tested each mutant for covalent sulfhydryl modification by the water-soluble reagent para-chloromercuribenzenesulfonate. Then, the authors assessed whether receptor-bound alphaxalone, etomidate, or propofol blocked cysteine modification, implying steric hindrance.

Results
Eleven mutant β3 subunits, when coexpressed with α1 and γ2L, formed functional channels that displayed varied sensitivities to the three anesthetics. Exposure to para-chloromercuribenzenesulfonate produced irreversible functional changes in ten mutant receptors. Protection by alphaxalone was observed in receptors with β3V290C, β3F293C, β3L297C, or β3F301C mutations. Both etomidate and propofol protected receptors with β3M286C or β3V290C mutations. Etomidate also protected β3F289C. In α1β3γ2L structural homology models, all these protected residues are located in transmembrane β+–α− interfaces.

Conclusions
Alphaxalone binds in transmembrane β+–α− pockets of synaptic GABAA receptors that are adjacent and intracellular to sites for the potent anesthetics etomidate and propofol.
Restoring Perceived Loudness for Listeners With Hearing Loss
Authors: Oetting Dirk , Hohmann Volker , Appell Jens-E. , Kollmeier Birger , Ewert Stephan D. 
Published: November 2017

Objectives:
Normalizing perceived loudness is an important rationale for gain adjustments in hearing aids. It has been demonstrated that gains required for restoring normal loudness perception for monaural narrowband signals can lead to higher-than-normal loudness in listeners with hearing loss, particularly for binaural broadband presentation. The present study presents a binaural bandwidth–adaptive dynamic compressor (BBDC) that can apply different gains for narrow- and broadband signals. It was hypothesized that normal perceived loudness for a broad variety of signals could be restored for listeners with mild to moderate high-frequency hearing loss by applying individual signal-dependent gain corrections.

Design:
Gains to normalize perceived loudness for narrowband stimuli were assessed in 15 listeners with mild to moderate high-frequency hearing loss using categorical loudness scaling. Gains for narrowband loudness compensation were calculated and applied in a standard compressor. Aided loudness functions for signals with different bandwidths were assessed. The deviation from the average normal-hearing loudness functions was used for gain correction in the BBDC. Aided loudness functions for narrow- and broadband signals with BBDC were then assessed. Gains for a 65 dB SPL speech-shaped noise of BBDC were compared with gains based on National Acoustic Laboratories’ nonlinear fitting procedure version 2 (NAL-NL2). The perceived loudness for 20 real signals was compared to the average normal-hearing rating.

Results:
The suggested BBDC showed close-to-normal loudness functions for binaural narrow- and broadband signals for the listeners with hearing loss. Normal loudness ratings were observed for the real-world test signals. The proposed gain reduction method resulted on average in similar gains as prescribed by NAL-NL2. However, substantial gain variations compared to NAL-NL2 were observed in the data for individual listeners. Gain corrections after narrowband loudness compensation showed large interindividual differences for binaural broadband signals. Some listeners required no further gain reduction for broadband signals; for others, gains in decibels were more than halved for binaural broadband signals.

Conclusion:
The interindividual differences of the binaural broadband gain corrections indicate that relevant information for normalizing perceived loudness of binaural broadband signals cannot be inferred from monaural narrowband loudness functions. Over-amplification can be avoided if binaural broadband measurements are included in the fitting procedure. For listeners with a high binaural broadband gain correction factor, loudness compensation for narrowband and broadband stimuli cannot be achieved by compression algorithms that disregard the bandwidth of the input signals. The suggested BBDC includes individual binaural broadband corrections in a more appropriate way than threshold-based procedures.