bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yap methylation‐induced FGL1 expression suppresses anti‐tumor immunity and promotes tumor progression in KRAS‐driven lung adenocarcinoma
Authors: Jiang Ji , Ye Pengfei , Sun Ningning , Zhu Weihua , Yang Mei , Yu Manman , Yu Jingjing , Zhang Hui , Gao Zijie , Zhang Ningjie , Guo Shijie , Ji Yuru , Li Siqi , Zhang Cuncun , Miao Sainan , Chai Mengqi , Liu Wenmin , An Yue , Hong Jian , Wei Wei , Zhang Shihao , Qiu Huan 
Published: September 2024

AbstractBackgroundDespite significant strides in lung cancer immunotherapy, the response rates for Kirsten rat sarcoma viral oncogene homolog (KRAS)‐driven lung adenocarcinoma (LUAD) patients remain limited. Fibrinogen‐like protein 1 (FGL1) is a newly identified immune checkpoint target, and the study of related resistance mechanisms is crucial for improving the treatment outcomes of LUAD patients. This study aimed to elucidate the potential mechanism by which FGL1 regulates the tumor microenvironment in KRAS‐mutated cancer.MethodsThe expression levels of FGL1 and SET1 histone methyltransferase (SET1A) in lung cancer were assessed using public databases and clinical samples. Lentiviruses were constructed for transduction to overexpress or silence FGL1 in lung cancer cells and mouse models. The effects of FGL1 and Yes‐associated protein (Yap) on the immunoreactivity of cytotoxic T cells in tumor tissues were evaluated using immunofluorescence staining and flow cytometry. Chromatin immunoprecipitation and dual luciferase reporter assays were used to study the SET1A‐directed transcriptional program.ResultsUpregulation of FGL1 expression in KRAS‐mutated cancer was inversely correlated with the infiltration of CD8+ T cells. Mechanistically, KRAS activated extracellular signal‐regulated kinase 1/2 (ERK1/2), which subsequently phosphorylated SET1A and increased its stability and nuclear localization. SET1A‐mediated methylation of Yap led to Yap sequestration in the nucleus, thereby promoting Yap‐induced transcription of FGL1 and immune evasion in KRAS‐driven LUAD. Notably, dual blockade of programmed cell death‐1 (PD‐1) and FGL1 further increased the therapeutic efficacy of anti‐PD‐1 immunotherapy in LUAD patients.ConclusionFGL1 could be used as a diagnostic biomarker of KRAS‐mutated lung cancer, and targeting the Yap‐FGL1 axis could increase the efficacy of anti‐PD‐1 immunotherapy.
One‐Pot Enzymatic Cascade for Toxicant Degradation and Sugar Acid Production
Authors: Pongsupasa Vinutsada , Punthong Pangrum , Chaiyen Pimchai , Wongnate Thanyaporn 
Published: September 2024

AbstractThis study introduces a novel one‐pot enzymatic cascade approach for converting toxicants and continuously generating an electron acceptor for production of sugar acids. This method offers a promising solution to concerns about pesticide toxicity and environmental contamination by transforming hazardous substances into a useful electron acceptor. This acceptor is then utilized to produce valuable chemicals with broad industrial applications, particularly in the food and pharmaceutical sectors. The cascade reaction employs organophosphate hydrolase (OPD) to convert pesticides into 4‐nitrophenol (4‐NP), which is subsequently transformed into 1,4‐benzoquinone by HadA monooxygenase (HadA). 1,4‐benzoquinone serves as an electron acceptor in the catalysis of sugar acid formation via pyranose dehydrogenase (PDH). The results indicate that this cascade reaction effectively converts lactose to lactobionic acid and xylose to 2‐keto‐xylonic acid. The latter can be further processed into xylonic acid through NaBH4 reduction. Notably, the one‐pot reaction yields up to 10 % higher compared to the direct addition of 1,4‐benzoquinone. The synthesized xylonic acid exhibits exceptional water uptake properties in hydrogels, and the synthesized lactobionic acid shows antioxidant activity comparable to well‐established antioxidants. These findings demonstrate the technological viability of these reaction cascades for various applications.
Evaluation of Federal Crop Insurance Corporation methods to estimate soft winter wheat grain yield in the Eastern United States
Authors: Lindsey Laura E. , Singh Maninder P. , Knott Carrie A. , Hankinson Matthew W. , Mudiyanselage Prabath Senanayaka , Houx James H. , Zarnstorff Mark 
Published: September 2024

AbstractSoft winter wheat (SWW) (Triticum aestivum L.) is vulnerable to environmental stressors throughout winter and early spring. To assess yield potential of SWW, crop insurance adjustors estimate grain yield by multiplying the number of stems ft−2 by a yield factor of 0.50. However, crop insurance adjustors believe the yield factor of 0.50 is too low. A 3‐year experiment was conducted in Michigan, Ohio, and Kentucky to compare predicted SWW yield to harvested yield. The existing yield factor underestimated SWW yield in 243 out of 246 comparisons. Average predicted yield was 40 bu acre−1 (range of 6 to 122 bu acre−1) while actual yield averaged 93 bu acre−1 (range of 51 to 124 bu acre−1). Due to the discrepancy in predicted and actual yield, data from a planting date and seeding rate experiment conducted at four site‐years in Ohio was used to establish a new yield factor based on the number of stems ft−2 and fractional green canopy cover (FGCC) measured with the Canopeo app at Feekes 5 growth stage. The new methods were applied to the original multi‐state dataset. Using a logarithmic function based on the number of stems ft−2, 50% of the predicted yield values were within −8 to 18 bu acre−1 of the actual yield values. A logarithmic function based on FGCC resulted in 50% of the predicted yield values within 3 to 18 bu acre−1 of the actual yield values. Overall, our results showed that new models performed better than the current method used by crop insurance adjustors.
Twisted Amide‐Mediated Peptide Synthesis
Authors: Koyama Ai , Kuranaga Takefumi , Suo Taiki , Morimoto Ryota , Matsumoto Takumi , Kakeya Hideaki 
Published: September 2024

AbstractA robust, practical, and sustainable isomerization‐suppressed peptide bond formation via acyl sulfonamide, a twisted amide, is disclosed. Tosyl isocyanate and pentafluorobenzyl bromide were applied in combination to activate the peptide C‐terminus, which then reacted with an amine to yield an elongated peptide with high stereochemical purity. Careful analysis of NMR spectra of the active intermediate revealed the presence of an intramolecular hydrogen bond, suggesting that the hydrogen bond suppressed Cα‐epimerization during amidation. The isomerization suppression by the intramolecular hydrogen bond is expected to be effective even under high dilution conditions, making the present method a powerful tool for the synthesis of complex macrocyclic peptides. In addition to peptide synthesis, the developed synthetic entry to twisted amides can be applied to the investigation of transition metal‐catalyzed N−C bond activation. Moreover, the application to the N−C bond activation returned insight into peptide synthesis, leading to the use of sulfonamide as a protecting group of carboxylic acid that can be orthogonally removed in the presence of other conventional protecting groups.
Green human resource practices for individual environmental performance: A meta‐review
Authors: Paillé Pascal 
Published: September 2024

AbstractThe field of green human resource management is a discreet but paradoxically very dynamic research topic. While many literature reviews have been published in recent years, none have explicitly addressed the links with environmental performance. This paper aims to fill this gap. An analysis of the literature indicates that compared to other practices associated with recruitment, rewards, or even performance evaluation, environmental training practices are the most commonly used. Analysis of the selected corpus shows that the effect of sustainable human resource management practices on environmental performance is mediated by several attitudinal, cognitive and conative variables. An integrative model is proposed to connect the different variables. The paper concludes with a discussion of the theoretical and practical implications of the study for the links between sustainable human resource management practices and individual environmental performance.
Pro‐environmental action plan for managers of distributed service facilities
Authors: Gawin Bartlomiej , Winiarski Jacek , Marcinkowski Bartosz 
Published: September 2024

AbstractGiven the variety of ways in which companies can communicate their pro‐ecological stances, it may be challenging to differentiate cursory Environmental, Social, and Corporate Governance (ESG) reporting from meaningful reporting, which is quantitatively supported and adequately monitored. Industry‐wide, a gap has emerged between corporate commitment to decarbonisation and tangible actions. For the most part, businesses continue to fall back on non‐verified data provided by a company that has not been externally audited. This study follows a qualitative research initiative focused on enhancing the questionable maturity of reporting in a reference business entity while simultaneously generating scientific knowledge. Through a series of documented interventions, we devise an environmental strategy action plan that complements highly abstract ESG strategies, with a depiction outlining specific measures for achieving key environmental performance indicators. Energy managers are provided with a validated structure for such a document, containing guidance on what information to include to effectively implement environmental statements in the overall sustainability strategies of their companies. We outline various avenues for companies, legislators, regulators, and organisations working on sustainability reporting frameworks to enhance reporting quality.
Do effective and sustainable corporate governance mechanisms affect the relevance of non‐financial information?
Authors: Zampella Annamaria , Campanella Francesco , Serino Luana , Spignese Alessia 
Published: September 2024

AbstractThe aim of this paper is to investigate the value relevance of non‐financial information (NFI) under the EU Directive 2014/95/EU, since its increasing importance over recent years. Adopting a panel data set with all listed firms in Germany, Spain, France and Italy, we obtain a final sample of 10,025 firms‐year‐observations in the period from 2017 to 2021. Through the lens of institutional theory, it emerges that firms adopt coercive, mimetic and normative pressure to be recognised by investors in their NFI practices. Furthermore, the presence of effective and sustainable corporate governance mechanisms improve accounting information (namely, Earnings Per Shares and Book Value of Equity Per Shares) and NFI. The contribution of this study is twofold. First of all, it enriches the literature about value relevance of NFI; second, it is beneficial for practitioners, such as investors, policy makers and regulators on the strategic levels of effective corporate governance mechanisms. NFI has a positive effect on capital market and improve investors' decision‐making by providing information on diversity, environmental matters, social and employees matters, human rights and anti‐corruption and bribery matters, which will favour the firms' implementation of more sustainable actions. Indeed, if investors recognise the importance of a certain firm's NFI, the market value of that firm will increase with consequent reputational and economic‐financial benefits. To the best of authors' knowledge, this is the first study that investigates the role of effective and sustainable corporate governance mechanisms on the value relevance of NFI.
Three‐Phase Neutral‐Point‐Clamped Multilevel Inverter Interfacing Grid Interactive Renewable Energy System
Authors: Kumar Dalai Sumant , Prasad Panda Kaibalya , Siwakoti Yam P. , Panda Gayadhar 
Published: September 2024

ABSTRACTThe potentiality of DC microgrid to incorporate renewable energy sources and improve power distribution efficiency has garnered considerable interest, especially in light of the ever‐increasing demand for efficient and clean energy systems. Multilevel inverters (MLIs) play a crucial role in interfacing these grid‐tied microgrids with various loads and energy sources. To improve the efficiency and dependability of such systems, this paper presents a three‐phase MLI interfacing solar photovoltaic (PV)‐battery‐based grid‐tied system. The system comprises of MLI with features such as (a) neutral point clamped input, (b) reduced number of switches to produce 7‐level output per phase, (c) self‐balanced capacitors, and (d) inherent voltage boosting ability. A novel power management control algorithm is designed to enhance the dynamic response and efficiency of the developed system. The effectiveness of the proposed system and its workability is validated through extensive experiments demonstrating enhanced power quality and efficient energy utilization.
Powerful knowledge and the 2022 Swedish social studies curriculum
Authors: Börjesson Mattias , Lilliestam Anna‐Lena 
Published: September 2024

AbstractIn the 21st century, the idea that students should have opportunities to develop powerful knowledge has been influential in educational research. Social realism as an educational philosophy, and a focus on knowledge derived from academic disciplines, have been advanced as an alternative to social constructivism and traditionalism as a basis for the curriculum. Drawing on these three educational philosophies, an analytical framework consisting of three curriculum models was developed: the traditional model, the social constructivist model and the social realist model. This analytical framework was used to identify underlying ideas in the Swedish social studies syllabi for civics, geography, history and religious education in the 2022 curriculum for compulsory school. The history syllabus aligns with social realist model, with a focus on disciplinary knowledge, that is students should understand how historical knowledge is produced and validated. The geography syllabus shows features of the traditional and the social constructivist model in that factual knowledge and students' everyday experiences are emphasised. The civics syllabus shows features of the traditional model, with a focus on subject knowledge. The religious studies syllabus also shows features of the traditional model with a focus on canonical knowledge, but also emphasises disciplinary knowledge that align with the social realist model.
Long‐Term Outcome and Mortality in Adolescent Girls 8 Years After Treatment for Anorexia Nervosa
Authors: Quadflieg Norbert , Naab Silke , Fichter Manfred , Voderholzer Ulrich 
Published: September 2024

ABSTRACTObjectiveAssessment of the longer‐term outcome of anorexia nervosa (AN) in female adolescent inpatients (N = 132).MethodA follow‐up (mean 8.2 years) after treatment was conducted. A subsample of 39 patients with at least 10 years of follow‐up (mean 14 years) was defined.ResultsOver the 8‐year follow‐up period, the body mass index (BMI) increased from 14.33 (1.65) to 19.04 kg/m2 (2.97; t[112] = 17.33, p < 0.001, d = 1.63), and BMI percentiles increased from 0.50 (1.14) to 24.96 (26.81; t[112] = 9.83, p < 0.001, d = 0.92). Remission was found in 32.5% (8‐year total sample) and 48.6% (14‐year subsample). In the 8‐year total sample, 15.1% still had AN or had relapsed (8.1% in the 14‐year subsample). A cross‐over from AN to binge‐eating disorder was rare. The main cross‐over occurred from AN to an eating disorder not otherwise specified (37.5% and 27.0%, respectively). The standardized mortality ratio was 21.7.DiscussionIn the long run, eating disorder diagnoses decreased significantly. Although a considerable proportion of patients recovered from their eating disorder, the number of recovered patients remained limited, with long‐term negative consequences in a large proportion of patients. Standardized mortality was excessive, calling for ever‐better therapies. Additional studies are needed to show if improved therapies lead to a better long‐term outcome.
Systemic lupus erythematosus and epilepsy: A Mendelian randomization study
Authors: Hu Yang , Lin Duo , Wu Dongmei , Zhang Yuqing , Li Gongbo 
Published: September 2024

AbstractObjectiveNumerous observational studies have found a relationship between systemic lupus erythematosus (SLE) and epilepsy; however, their causal relationship remains unclear. This study aimed to investigate the causal role of SLE in epilepsy or any of its subtypes using a two‐sample Mendelian randomization (MR) analysis.MethodsSingle nucleotide polymorphisms (SNPs) linked to SLE were utilized as instrumental variables in MR analysis to assess their causal impact on epilepsy. The primary MR findings were derived using the inverse variance weighted (IVW) method, which was further supported by the weighted median and MR‐Egger regression techniques. Additionally, sensitivity analyses, including Cochran's Q test and pleiotropy tests, were conducted to evaluate the influence of these SNPs on epilepsy, particularly looking for signs of horizontal pleiotropy and heterogeneity.ResultsWe selected 43 SNPs that reached genome‐wide significance from genome‐wide association studies (GWASs) on SLE to serve as instrumental variables in this study. The IVW method showed no evidence to support a causal association between SLE and epilepsy (all epilepsy: odds ratio (OR) = 1.006, 95% confidence interval (CI) = 0.994–1.018; focal epilepsy: OR = 1.006, 95% CI = 0.994–1.019; generalized epilepsy: OR = 1.015, 95% CI = 0.996–1.035). Other MR complementary methods revealed consistent results. Furthermore, there was no evidence indicating heterogeneity or horizontal pleiotropy.SignificanceThe findings of MR analysis did not support a genetically predicted causal relationship between SLE and epilepsy, but emphasized the need for further research on shared pathophysiological mechanisms, particularly the role of immune system abnormalities and potential influences such as chronic inflammation and therapeutic interventions.Plain Language SummaryThe etiology of epilepsy is complex and diverse, including immune factors. Through a Mendelian randomization analysis, we did not find evidence of a genetic causal relationship between systemic lupus erythematosus and epilepsy. However, this does not invalidate epidemiological evidence, and further exploration is needed to investigate factors influencing the relationship between the two.
Estimation of inelastic displacement ratio spectrum for existing RC structures via displacement response spectrum
Authors: Dadheech Sakshee , Gupta Vinay K. 
Published: September 2024

AbstractIn the present seismic design philosophy, the structures are designed to remain within the specified displacement limits for multiple earthquake hazard levels expected during their design life. Accordingly, the estimation of maximum inelastic displacement demand in a structure consistent with a given hazard level is of primary importance. Considering the complexity and inconvenience associated with the nonlinear response history analyses for a suite of hazard‐consistent ground motions, it is preferred to estimate the maximum inelastic displacement demand by using the scaling models available for the inelastic displacement ratio in the single‐degree‐of‐freedom (SDOF) structures. In this study, a new scaling model is developed for the inelastic displacement ratio spectrum for a given response reduction factor R in the case of 5%‐initial damping Bouc‐Wen‐Baber‐Noori (BWBN) oscillators with stiffness and strength degradations and pinching. This model is based on the observed similarities between the spectrum and the reciprocal of given displacement response SD() spectrum in most cases, and thus, this indirectly accounts for the effects of seismological and site parameters. A new strong‐motion duration definition is also proposed to identify shorter strong‐motion segments of comparable relevance, and on using this definition, it is shown that the dependence of the mean spectrum on strong‐motion duration may be considered negligible. Accordingly, the regression parameters of the proposed scaling model for spectrum are estimated as the exponential functions of only five governing BWBN parameters. The best‐fit estimates of the regression coefficients of the resulting prediction equations are obtained for three values of R. The residual error spectra are also modeled to estimate the spectrum for a given confidence level. The proposed scaling model can be applied to a wide range of existing reinforced concrete (RC) structures with 5% initial damping by using the input of the design displacement spectrum and BWBN parameters.
First Record of Loropetalum chinense (Hamamelidaceae) in Flora of Vietnam
Authors: Zhu Zhen‐Hua , Lei Shu‐Qing , Pham Quang Canh , Hoang Trong Thang , Hoang Thanh Son , Li Bo 
Published: September 2024

ABSTRACTLoropetalum chinense (R.Br.) Oliv., a species that was previously documented to only be distributed in China, Japan, and India, with all distribution records north of the Tropic of Cancer, has now been recorded for the flora of Vietnam. The newly discovered population from the Son La Province in northwestern Vietnam, south of the Tropic of Cancer, represents the southernmost extent of the distribution of L. chinense. Detailed morphological descriptions, field photos, and a distribution map were provided.
A nanozyme catalysis‐diazotization reaction cascaded ratiometric colorimetric assay probing the dynamics of nitrite in leftovers
Authors: Zhang Ziyu , Tang Lina , Sheng Wenjie , Yang Youyi , Lai Guolin , Liu Jinjin , Niu Xiangheng 
Published: September 2024

AbstractAs a common food additive, excessive nitrite poses a great threat to human health, and monitoring its content in food products is of importance for healthy diet. Currently, the detection of nitrite content in food is primarily focused on fresh dishes, and there is a lack of research on monitoring the variations of nitrite in different foods under various storage conditions. In this study, we cascaded nanozyme catalysis with diazotization reaction and developed a ratiometric colorimetric assay to dynamically analyze nitrite in leftovers. First, nanoscale MnFe2O4 was synthesized as an oxidase mimic to catalyze colorless 3,3′,5,5′‐tetramethylbenzidine (TMB) oxidation to blue TMBox. Then, a diazotization process of the produced TMBox took place under the stimulation of nitrite, lowering the ultraviolet‐visible absorption signal (652 nm) assigned to TMBox and simultaneously generating a new signal at 445 nm ascribed to diazotized TMBox. Thus, a ratiometric colorimetric method could be constructed based on the above reversed variations of the two signals for high‐selectivity nitrite determination, providing a linear range of 1.76–180 μM and a detection limit of 0.12 μM. By employing the established assay to dynamically monitor nitrite in food products, it was found that the nitrite content in overnight leftovers was higher than that in fresh dishes, presenting an increasing trend with storage time. In addition, potential impacts of storage factors on the dynamics of nitrite content were investigated, providing some implications for food preservation and daily consumption.
Effects of the Medicaid coverage cliff on low‐income elderly Medicare beneficiaries
Authors: Koh Kanghyock , Park Sungchul 
Published: September 2024

AbstractThe Medicaid coverage “cliff” occurs when Medicare beneficiaries with household income exceeding 100% of the federal poverty level lose eligibility for supplemental Medicaid coverage. Using a regression discontinuity design with data from Medical Expenditure Panel Survey and National Health and Nutrition Examination Survey for 2007–2019, we demonstrate that the cliff increases out‐of‐pocket spending by 25% and the probability of experiencing problems paying medical bills by 44.4% without decreases in overall health care spending. However, there is evidence that near‐poor Medicare beneficiaries changed behavior in response to the cliff, increasing the use of high‐value diagnostic and preventive testing by 8.8% and enrollment in a more affordable plan by 12.2%. The cliff does not encourage healthy behavior.