bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investor Reaction to Covert Corporate Political Activity
Authors: Werner Timothy 
Published: July 2017

Research summary: Citizens United v. Federal Election Commission and subsequent developments created a covert channel for firms to allocate resources from corporate treasuries to political activity. Through the use of a financial market event study of an accidental disclosure of firms' contributions to a Republican nonprofit organization, I examine investors' reactions to covert investment in independent political expenditures. I find that, on average, contributing firms experienced positive abnormal returns around the disclosure event and that these abnormal returns were more positive for firms in heavily regulated industries as well as those previously making campaign contributions to candidates. However, firms that recently faced a shareholder resolution on political spending disclosure experienced negative abnormal returns, suggesting that the controversial nature of covert activity moderated investors' reactions.Managerial summary: The purpose of this study is to examine how investors reacted to an accidental disclosure of firms' investments in “dark money,” a new form of corporate political activity allowed by the U.S. Supreme Court in its Citizens United decision. I find that, on average, investors reacted positively toward firms identified as making these new political investments, especially if the firms previously engaged in electoral politics or operate in heavily regulated industries. However, this reaction turned negative if the firm recently faced a shareholder resolution asking that it voluntarily disclose all of its political investments. An implication for managers is that they should consider their firms' legal and information environments as fully as possible before committing resources to new and potentially controversial political tactics. Copyright © 2017 John Wiley & Sons, Ltd.
Instandsetzung und Verstärkung von Stahlbrücken mit Kategorie‐1‐Schäden
Authors: Stranghöner Natalie , Lorenz Christoph , Friedrich Heinz 
Published: July 2017

AbstractDurch die in den letzten Jahren enorm gestiegenen Verkehrsbelastungen und damit einhergehenden gestiegenen lokalen Beanspruchungen im Deckblech kommt es bei bestehenden Stahlbrücken mit orthotropen Fahrbahnplatten vermehrt zu Ermüdungsschäden im Bereich der geschweißten Anschlüsse der Längsrippen an das Deckblech (Kategorie‐1‐Schäden). Der vorliegende Beitrag gibt einen Überklick über existierende Verstärkungsmaßnahmen, die bereits in Pilotprojekten erprobt wurden sowie aktuelle Forschungsarbeiten zur Verstärkung von orthotropen Fahrbahnplatten mit Kategorie‐1‐Schäden.
Polymer Nanoassembly as Delivery Systems and Anti‐Bacterial Toolbox: From PGMAs to MSN@PGMAs
Authors: Wu Ming‐Xue , Wang Xin , Yang Ying‐Wei 
Published: July 2017

AbstractResearches on cargo delivery systems have received burgeoning attention and advanced rapidly. For synthetic nanodevices, polymer nanoassemblies and their inorganic‐organic hybrid materials, especially smart mesoporous silica nanoparticle (MSN)‐polymer hybrids (e. g., MSN@PGMAs), have attracted increasing attention in recent years. Their superior characteristics and unique features such as dynamic transition of morphology endow them the ability to efficiently entrap cargo molecules and undergo smart cargo delivery and release in response to various external stimuli. In this Personal Account, we present our recent research progress in the construction of cargo delivery systems based on polymers, poly(glycidyl methacrylate) (PGMA) and its derivatives in particular, ranging from polymer nanoparticles, reverse micelles, to vesicles and reverse vesicles, and their performance in the delivery and controlled release of model molecules and therapeutic agents. Significantly, MSN‐PGMA hybrid nanoassemblies (MSN@PGMAs), constructed with the aid of atom transfer radical polymerization, host‐guest interactions, or layer‐by‐layer self‐assembly techniques, and their potential bio‐related applications and anti‐bacterial applications as new nanocarriers are reviewed. Finally, the prospects and challenges of such nanoplatforms are also discussed.
Optogenetik als mögliche Therapie bei degenerativen Netzhauterkrankungen
Authors: Mutter Marion , Benkner Boris , Münch Thomas A. 
Published: July 2017

Zusammenfassung
Bei neurodegenerativen Erkrankungen der Netzhaut sind die lichtempfindlichen Zellen, die Photorezeptoren, oft als Erstes betroffen. Die Optogenetik ist ein vielversprechender Ansatz, die Netzhaut wieder lichtempfindlich zu machen und dadurch das Sehvermögen wiederherzustellen. Bei der Optogenetik werden lichtempfindliche Proteine über gentechnische Methoden in die Netzhaut eingebracht; die Aktivität der Zielzellen wird durch diese Behandlung durch Licht beeinflussbar. Dieser Einfluss kann die direkte lichtinduzierte Änderung des Membranpotenzials sein (sowohl hemmend als auch erregend) oder die lichtinduzierte Aktivierung intrazellulärer Signalkaskaden. Dies hat zur Folge, dass das Zielgewebe, die Netzhaut, wieder auf Licht reagiert. Diese Übersicht beschreibt die Prinzipien der Optogenetik und den gegenwärtigen Stand im Hinblick auf ihre Anwendung zur Behandlung von Blindheit.
The relationship between work and home characteristics and work engagement in medical residents
Authors: Verweij Hanne , Van Hooff Madelon L. M. , Van der Heijden Frank M. M. A. , Prins Jelle T. , Lagro-Janssen Antoine L. M. , Van Ravesteijn Hiske , Speckens Anne E. M. 
Published: July 2017

Introduction Work engagement is important for medical residents and the healthcare organizations they work for. However, relatively little is known about the specific predictors of work engagement in medical residents. Therefore, we examined the associations of work and home characteristics, and work-home interference with work engagement in male and female residents.
Methods This study was conducted on a nationwide sample of medical residents. In 2005, all Dutch medical residents (n = 5245) received a self-report questionnaire. Path analysis was used to examine the associations between the potential predictors and work engagement.
Results In total, 2115 (41.1%) residents completed the questionnaire. Job characteristics, home characteristics and work-home interference were associated with work engagement. Important positive contributing factors of work engagement were opportunities for job development, mental demands at work, positive work-home interference and positive home-work interference. Important negative contributing factors were emotional demands at work and negative home-work interference. The influence of these factors on work engagement was similar in male and female residents.
Discussion Opportunities for job development and having challenging work are of high relevance in enhancing work engagement. Furthermore, interventions that teach how to deal skilfully with emotional demands at work and home-work interference are expected to be the most effective interventions to enhance work engagement in medical residents.
What's mine is yours: Stable variation and language change in Ancient Egyptian possessive constructions
Authors: Gardiner Shayna 
Published: July 2017

AbstractVariation is described as two or more variants competing for finite resources. In this model, two outcomes are possible: language change or specialization. Specialization can be broken down further: specialization for different functions, and partial specialization – stable variation. In this paper, I analyze the differences between stable variation and language change using the two variables present in Ancient Egyptian possessive constructions. Observing four Egyptian possessive variants, split into two groups with two variants each – clitic possessor variants and full nominal possessor variants – for a total of 2251 tokens, I compare factors affecting variant choice in each possessive group. Results of distributional and multivariate analyses indicate that a) change over time occurs in clitic possession, while stable variation occurs with noun variants; and b) different kinds of factors govern the two sets: the continuous variable phrase complexity affects variant choice in nominal possession, but does not affect the clitic variants.
Significance of lung anomalies in fetuses affected by tetralogy of Fallot with absent pulmonary valve syndrome
Authors: Tenisch Estelle , Raboisson Marie-Josée , Rypens Françoise , Déry Julie , Grignon Andrée , Lapierre Chantale 
Published: July 2017

AbstractObjectivesTetralogy of Fallot with absent pulmonary valve syndrome is a rare form of tetralogy of Fallot with dilatation of large pulmonary arteries. Prognosis is related to the severity of the cardiac malformation and to bronchial tree compression by dilated pulmonary arteries. This study analyses the prenatal echographic lung appearance in fetuses with tetralogy of Fallot with absent pulmonary valve and discusses its significance.MethodsWe carried out a retrospective review of fetal and postnatal files of nine fetuses diagnosed with tetralogy of Fallot with absent pulmonary valve syndrome in our institution. Correlations of prenatal ultrasound and cardiac imaging findings were obtained with outcome.ResultsAbnormal heterogeneous fetal lung echogenicity was detected in eight cases out of nine, always associated with significant lobar arterial dilatation. This aspect was well correlated with postnatal imaging and outcome in the four neonatal cases. The only fetus with normal lung echogenicity also had lower degree of pulmonary artery dilatation in the series.ConclusionsThis study demonstrates that a heterogeneous ultrasound appearance of the fetal lungs can be detected in utero in the most severe cases. This aspect suggests an already significant compression of the fetal bronchial tree by the dilated arteries that may have prognostic implications.
CASP solutions for planning in hybrid domains
Authors: BALDUCCINI MARCELLO , MAGAZZENI DANIELE , MARATEA MARCO , LEBLANC EMILY C. 
Published: July 2017

AbstractConstraint answer set programming (CASP) is an extension of answer set programming that allows for numerical constraints to be added in the rules. PDDL+ is an extension of the PDDL standard language of automated planning for modeling mixed discrete-continuous dynamics. In this paper, we present CASP solutions for dealing with PDDL+ problems, i.e., encoding from PDDL+ to CASP, and extensions to the algorithm of theezcspCASP solver in order to solve CASP programs arising from PDDL+ domains. An experimental analysis, performed on well-known linear and non-linear variants of PDDL+ domains, involving various configurations of theezcspsolver, other CASP solvers, and PDDL+ planners, shows the viability of our solution.
A tricyclic antidepressant, amoxapine, reduces amyloid-β generation through multiple serotonin receptor 6-mediated targets
Authors: Li Xiaohang , Wang Qinying , Hu Tingting , Wang Ying , Zhao Jian , Lu Jing , Pei Gang 
Published: July 2017

AbstractAlzheimer’s disease (AD) is a major and devastating neurodegenerative disease, and the amyloid-β (Aβ) hypothesis is still the central theory for AD pathogenesis. Meanwhile, another major mental illness, depression, is one of the risk factors for AD. From a high-throughput screening (HTS), amoxapine, a typical secondary amine tricyclic antidepressant (TCA), was identified to reduce Aβ production. A follow-up investigation on antidepressants showed that most of the TCAs harbour similar activity. Previous studies have indicated that TCAs improve cognitive function in AD mouse models as well as in preliminary clinical data; however, the underlying mechanism is controversial, and the effect on Aβ is elusive. Thus, we developed a secondary screening to determine the molecular target of amoxapine, and serotonin receptor 6 (HTR6) was identified. Knockdown of HTR6 reduced the amoxapine’s effect, while the HTR6 antagonist SB258585 mimicked the activity of amoxapine. Further mechanistic study showed that amoxapine and SB258585 reduced Aβ generation through multiple HTR6-mediated targets, including β-arrestin2 and CDK5. Taken together, our study suggests that amoxapine, though no longer a first-line drug for the treatment of depression, may be beneficial for AD and further structural modification of TCAs may lead to desirable therapeutic agents to treat both AD and depression.
Non-invasive imaging of engineered human tumors in the living chicken embryo
Authors: Jefferies Benedict , Lenze Florian , Sathe Anuja , Truong Nguyen , Anton Martina , von Eisenhart-Rothe Rüdiger , Nawroth Roman , Mayer-Kuckuk Philipp 
Published: July 2017

AbstractThe growing interest in engineered tumor models prompted us to devise a method for the non-invasive assessment of such models. Here, we report on bioluminescence imaging (BLI) for the assessment of engineered tumor models in the fertilized chicken egg, i.e, chick chorioallantoic membrane (CAM) assay. One prostate cancer (PC-3) and two osteosarcoma (MG63 and HOS) cell lines were modified with luciferase reporter genes. To create engineered tumors, these cell lines were seeded either onto basement membrane extract (BME) or gelfoam scaffolds, and subsequently grafted in vivo onto the CAM. BLI enabled non-invasive, specific detection of the engineered tumors on the CAM in the living chicken embryo. Further, BLI permitted daily, quantitative monitoring of the engineered tumors over the course of up to 7 days. Data showed that an extracellular matrix (ECM) composed of BME supported growth of reporter gene marked PC-3 tumors but did not support MG63 or HOS tumor growth. However, MG63 tumors engineered on the collagen-based gelfoam ECM showed a temporal proliferation burst in MG63 tumors. Together, the data demonstrated imaging of engineered human cancer models in living chicken embryos. The combination of CAM assay and BLI holds significant potential for the examination of a broad range of engineered tumor models.
Phylogenomic analysis of MKKs and MAPKs from 16 legumes and detection of interacting pairs in chickpea divulge MAPK signalling modules
Authors: Purayannur Savithri , Kumar Kamal , Kaladhar Vemula Chandra , Verma Praveen Kumar 
Published: July 2017

AbstractThe mitogen-activated protein kinase (MAPK)-mediated phosphorylation cascade is a vital component of plant cellular signalling. Despite this, MAPK signalling cascade is less characterized in crop legumes. To fill this void, we present here a comprehensive phylogeny of MAPK kinases (MKKs) and MAPKs identified from 16 legume species belonging to genistoid (Lupinus angustifolius), dalbergioid (Arachis spp.), phaseoloid (Glycine max, Cajanus cajan, Phaseolus vulgaris, and Vigna spp.), and galegoid (Cicer arietinum, Lotus japonicus, Medicago truncatula, Pisum sativum, Trifolium spp., and Vicia faba) clades. Using the genes of the diploid crop chickpea (C. arietinum), an exhaustive interaction analysis was performed between MKKs and MAPKs by split-ubiquitin based yeast two-hybrid (Y2H). Twenty seven interactions of varying strengths were identified between chickpea MKKs and MAPKs. These interactions were verified in planta by bimolecular fluorescence complementation (BiFC). As a first report in plants, four intra-molecular interactions of weak strength were identified within chickpea MKKs. Additionally; two TEOSINTE-BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors of class I were identified as novel down-stream interacting partners of seven MAPKs. We propose that this highly reliable MAPK interaction network, presented here for chickpea, can be utilized as a reference for legumes and thus will help in deciphering their role in legume-specific events.
Physical Binding of Endothelial MCAM and Neural Transmembrane Protease Matriptase—Novel Cell Adhesion in Neural Stem cell Vascular Niche
Authors: Tung Hsiu-Hui , Lee Sheau-Ling 
Published: July 2017

AbstractBrain neural stem cells and transit amplifying cells in the subventricular zone (SVZ) of the lateral ventricles are in direct contact with the microvascular endothelium. The mechanisms/molecules of direct cell contact in the SVZ neurovascular niche are not fully understood. We previously showed that neural stem/progenitor (NS/P) cells induce brain endothelial signaling in direct cell contact through matriptase (MTP) on NS/P cell surface. In the present study, using pull-down and LC-MS/MS, we identified melanoma cell adhesion molecule (MCAM) the brain endothelial molecule that interacts with MTP. MCAM physically binds to the CUB domains of MTP and induces a chain of brain endothelial signaling including p38MAPK activation, GSK3β inactivation and subsequently β-catenin activation; none of these signaling events occurred when either MTP or MCAM is deleted. MTP-MCAM binding and induction of endothelial signaling were all sensitive to cholera toxin. Together, we identified key molecules that may represent a mechanism in neural stem cell vascular niche regulation.
Future changes in the climatology of the Great Plains low-level jet derived from fine resolution multi-model simulations
Authors: Tang Ying , Winkler Julie , Zhong Shiyuan , Bian Xindi , Doubler Dana , Yu Lejiang , Walters Claudia 
Published: July 2017

AbstractThe southerly Great Plains low-level jet (GPLLJ) is one of the most significant circulation features of the central U.S. linking large-scale atmospheric circulation with the regional climate. GPLLJs transport heat and moisture, contribute to thunderstorm and severe weather formation, provide a corridor for the springtime migration of birds and insects, enhance wind energy availability, and disperse air pollution. We assess future changes in GPLLJ frequency using an eight member ensemble of dynamically-downscaled climate simulations for the mid-21st century. Nocturnal GPLLJ frequency is projected to increase in the southern plains in spring and in the central plains in summer, whereas current climatological patterns persist into the future for daytime and cool season GPLLJs. The relationship between future GPLLJ frequency and the extent and strength of anticyclonic airflow over eastern North America varies with season. Most simulations project a westward shift of anticyclonic airflow in summer, but uncertainty is larger for spring with only half of the simulations suggesting a westward expansion. The choice of regional climate model and the driving lateral boundary conditions have a large influence on the projected future changes in GPLLJ frequency and highlight the importance of multi-model ensembles to estimate the uncertainty surrounding the future GPLLJ climatology.
Temperature effects on an InGaP (GaInP) 55Fe X-ray photovoltaic cell
Authors: Butera S. , Whitaker M. D. C. , Krysa A. B. , Barnett A. M. 
Published: July 2017

AbstractThis paper investigates the effects of temperature on an InGaP (GaInP) 55Fe X-ray photovoltaic cell prototype for a radioisotope microbattery (also called a nuclear microbattery). An In0.5Ga0.5P p-i-n (5 μm i-layer) mesa photodiode was illuminated by a standard 206 MBq 55Fe radioisotope X-ray source and characterised over the temperature range −20 °C to 100 °C. The electrical power output of the device reached its maximum value of 1.5 pW at a temperature of −20 °C. An open circuit voltage and a short circuit current of 0.82 V and 2.5 pA, respectively, were obtained at −20 °C. While the electrical power output and the open circuit voltage decreased with increasing temperature, an almost flat trend was found for the short circuit current. The cell conversion efficiency decreased from 2.1% at −20 °C to 0.7% at 100 °C.
Modelling West Nile virus transmission risk in Europe: effect of temperature and mosquito biotypes on the basic reproduction number
Authors: Vogels Chantal B. F. , Hartemink Nienke , Koenraadt Constantianus J. M. 
Published: July 2017

AbstractWest Nile virus (WNV) is a mosquito-borne flavivirus which has caused repeated outbreaks in humans in southern and central Europe, but thus far not in northern Europe. The main mosquito vector for WNV, Culex pipiens, consists of two behaviourally distinct biotypes, pipiens and molestus, which can form hybrids. Differences between biotypes, such as vector competence and host preference, could be important in determining the risk of WNV outbreaks. Risks for WNV establishment can be modelled with basic reproduction number (R0) models. However, existing R0 models have not differentiated between biotypes. The aim of this study was, therefore, to explore the role of temperature-dependent and biotype-specific effects on the risk of WNV establishment in Europe. We developed an R0 model with temperature-dependent and biotype-specific parameters, and calculated R0 values using the next-generation matrix for several scenarios relevant for Europe. In addition, elasticity analysis was done to investigate the contribution of each biotype to R0. Global warming and increased mosquito-to-host ratios can possibly result in more intense WNV circulation in birds and spill-over to humans in northern Europe. Different contributions of the Cx. pipiens biotypes to R0 shows the importance of including biotype-specific parameters in models for reliable WNV risk assessments.
CD44v8-10 as a potential theranostic biomarker for targeting disseminated cancer cells in advanced gastric cancer
Authors: Choi Eun-Seok , Kim Hyunjin , Kim Hyung-Pyo , Choi Yongdoo , Goh Sung-Ho 
Published: July 2017

AbstractGastric cancer is the third most common cause of cancer mortality, and the survival rate of stage IV advanced gastric cancer (AGC) patients with distant metastasis is very low. Thus, the detection and eradication of disseminated cancer cells by targeting cell surface molecules in AGC would improve patient survival. The hyaluronic acid receptor, CD44, has various isoforms generated by alternative splicing, and some isoforms are known to be correlated to gastric cancer. In this study, to find out the most appropriate CD44v for targeting AGC, we analysed the expression differences of CD44 isoforms at the mRNA level in stomach cancer cell lines as well as in 74 patients with AGC by using exon-specific qRT-PCR. Among the CD44v isoforms, CD44v8-10 was determined as the most promising biomarker for the development of theranostic agents of gastric cancer. Next, we synthesised the conjugate of anti-CD44v9 antibody with near-infrared fluorophore or photosensitiser, and then demonstrated its feasibility for target cell-specific imaging and photoimmunotherapy in gastric cancer. As a result, these conjugates have clearly demarcated the surface of CD44v8-10 expressing cancer cells and showed efficient phototoxic effects. Therefore, this study revealed that CD44v8-10 is the efficient theranostic biomarker to target disseminated cancer cells in AGC.