bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE FERMI–GBM THREE-YEAR X-RAY BURST CATALOG
Authors: Jenke P. A. , Linares M. , Connaughton V. , Beklen E. , Camero-Arranz A. , Finger M. H. , Wilson-Hodge C. A. 
Published: August 2016

ABSTRACT
The Fermi Gamma-ray Burst Monitor (GBM) is an all-sky gamma-ray monitor well known in the gamma-ray burst (GRB) community. Although GBM excels in detecting the hard, bright extragalactic GRBs, its sensitivity above 8 keV and its all-sky view make it an excellent instrument for the detection of rare, short-lived Galactic transients. In 2010 March, we initiated a systematic search for transients using GBM data. We conclude this phase of the search by presenting a three-year catalog of 1084 X-ray bursts. Using spectral analysis, location, and spatial distributions we classified the 1084 events into 752 thermonuclear X-ray bursts, 267 transient events from accretion flares and X-ray pulses, and 65 untriggered gamma-ray bursts. All thermonuclear bursts have peak blackbody temperatures broadly consistent with photospheric radius expansion (PRE) bursts. We find an average rate of 1.4 PRE bursts per day, integrated over all Galactic bursters within about 10 kpc. These include 33 and 10 bursts from the ultra-compact X-ray binaries 4U 0614+09 and 2S 0918-549, respectively. We discuss these recurrence times and estimate the total mass ejected by PRE bursts in our Galaxy.
Il y a quelqu’un ? Dépression du postpartum et attachement
Authors: Papiasvili Eva D. , Mayers Linda A. 
Published: August 2016

Cet article présente une vue d’ensemble développemental et dynamique de nombreuses dimensions de processus liés à l’attachement activés dans les conditions de la dépression maternelle. La vignette clinique analytique reconstructive avec une patiente adulte illustre l’impact profond de la dépression maternelle sur une différenciation précoce entre les styles d’attachement de la mère dépressive et du soignant de substitut, à l’origine de premier « Counter-dépendant » autosuffisance. Grâce au travail d’interprétation, tout d’abord avec les « enactments » et puis les rêves, se rapportant aux événements des premiers balbutiements non rappelés, représentés ou symbolisés, la patiente est capable de faire une série de sauts symboliques développementaux transformateurs, de rétablir la capacité d’intimité, d’espoir, de confiance et de plaisir. Cela casse la transmission intergénérationnelle de la mère-fille de dépression post-partum et l’attachement problématique connexe.
Conséquences précoces de la privation maternelle au cours de la période préœdipienne
Authors: Markman Reubins Beatriz 
Published: August 2016

Cet article cherche à montrer les conséquences précoces d’une privation maternelle au cours de la période préœdipienne et pour ce faire, questionne les premières théories ainsi que les techniques de la psychanalyse d’enfant. Ces théories diffèrent dans leur compréhension et leur conceptualisation de la psychopathologie infantile, néanmoins elles ont toutes un dénominateur commun : toutes soulignent l’importance des premières expériences du nourrisson ainsi que la nécessité d’une constance physique et émotionnelle de la dyade mère-enfant. Cet article passe en revue les différentes théories et présente trois vignettes cliniques. À travers le récit de la thérapie d’un petit garçon de quatre ans, nous découvrons comment les conflits et les symptômes évoluent et finissent par se résoudre au cours de cinq années de thérapie. Pour finir, le jeune garçon modifie son comportement et ses actes, ce qui permet de mettre fin au traitement. Grâce à l’analyse, il a pu dépasser une expérience de séparation traumatisante et développer des mécanismes de défense matures, ce qui lui a permis de mieux s’adapter à son environnement. Nous pouvons donc conclure qu’une interruption précoce des soins maternels peut entraîner des troubles importants dans le comportement d’un enfant ainsi que son organisation mentale. Si ces difficultés ne sont pas traitées suffisamment tôt, les symptômes n’en deviendront que plus sévères.
La relation entre les parents et le bébé prématuré
Authors: Mathelin Catherine 
Published: August 2016

Devenir parents n’est jamais si facile. Nous savons qu’un important remaniement psychique doit pouvoir s’effectuer pour la mère et pour le père. Le couple doit lui aussi trouver de nouveaux repères. Mais lorsqu’il s’agit d’une naissance prématurée c’est certainement encore plus compliqué. Comment en effet devenir parents d’un minuscule bébé en danger ? La peur et la culpabilité prennent le devant de la scène. Le bébé qui vient de naître et dont on ne connaît pas encore le pronostic vital, fait véritablement effraction dans la vie des parents qui se retrouvent souvent empêchés de créer le lien avec lui. Le fantasme rejoint la réalité nous sommes là au cœur de la définition du trauma. Comment travailler avec ces parents en grande difficulté, et redonner au nourrisson une change de trouver sa place dans l’histoire familiale ?
Application des concepts psychanalytiques aux thérapies parents-nourrissons, travail d’interprétation et d’intervention directe auprès des bébés.
Authors: Anzieu-Premmereur Christine 
Published: August 2016

Comment peut-on appliquer la métapsychologie freudienne au travail analytique avec des nourrissons et leurs parents ? Des concepts tels que défense, transfert, sexualité infantile, Moi corporel, et surmoi peuvent-ils s’appliquer dès le début de la vie ? Le cas d’un nouveau né qui fuit le regard de sa mère qui ne peut éprouver d’amour pour un enfant né d’un don d’ovocyte est interprété avec le concept winnicottien de Surmoi précoce et de trouble dans la relation libidinale, associés à la notion de défense contre l’angoisse primitive et du rôle des projections maternelles inconscientes.
L’identification chez l’enfant autiste : parcours et extension du concept dans la théorie post- kleinienne
Authors: Franco e Silva Velano Marília 
Published: August 2016

La description du mécanisme de l’identification projective chez Melanie Klein a permis d’importantes avancées sur le plan théorique et clinique dans le domaine de la psychose. Néanmoins, face aux phénomènes de l’écholalie et l’échopraxie chez les enfants autistes, les post-kleiniens ont dû mettre en question certains de ces postulats comme, par exemple, la notion du Moi précoce comme donnée d’emblée. Cet article examine 1’extension du concept de l’identification chez les post-kleiniens – de l’identification projective à l’identification adhésive – et ses implications théoriques et cliniques autour de la question de l’autisme.
La violence du silence. Une mère sans voix
Authors: Moulin Géraldine 
Published: August 2016

À partir d’une rencontre en maternité avec une femme mutique et son bébé, nous interrogerons dans cet article la fonction de porte-parole de la mère . La mère, en interprétant le cri du bébé comme une demande « préforme à jamais ce qui sera demandé ». Mais lorsque la mère ne répond pas au cri du bébé, qu’elle ne l’entend pas comme un appel, que se passe-t-il ? Quelle place occupe alors la voix du psychanalyste dans cette rencontre ? Peut-il aider le bébé à se faire entendre ?
A New Paradigm to Analyze Data Completeness of Patient Data
Authors: Nasir Ayan , Liu Xinliang , Gurupur Varadraj 
Published: August 2016

SummaryThere is a need to develop a tool that will measure data completeness of patient records using sophisticated statistical metrics. Patient data integrity is important in providing timely and appropriate care. Completeness is an important step, with an emphasis on understanding the complex relationships between data fields and their relative importance in delivering care. This tool will not only help understand where data problems are but also help uncover the underlying issues behind them.Develop a tool that can be used alongside a variety of health care database software packages to determine the completeness of individual patient records as well as aggregate patient records across health care centers and subpopulations.Methods: The methodology of this project is encapsulated within the Data Completeness Analysis Package (DCAP) tool, with the major components including concept mapping, CSV parsing, and statistical analysis.The results from testing DCAP with Healthcare Cost and Utilization Project (HCUP) State Inpatient Database (SID) data show that this tool is successful in identifying relative data completeness at the patient, subpopulation, and database levels. These results also solidify a need for further analysis and call for hypothesis driven research to find underlying causes for data incompleteness.DCAP examines patient records and generates statistics that can be used to determine the completeness of individual patient data as well as the general thoroughness of record keeping in a medical database. DCAP uses a component that is customized to the settings of the software package used for storing patient data as well as a Comma Separated Values (CSV) file parser to determine the appropriate measurements. DCAP itself is assessed through a proof of concept exercise using hypothetical data as well as available HCUP SID patient data.Citation: Nasir A, Gurupur V, Liu X. A new paradigm to analyze data completeness of patient data.
Perioperative Cefovecin to Reduce the Incidence of Urinary Tract Infection in Dogs Undergoing Hemilaminectomy
Authors: Palamara Joseph D. , Bonczynski Jennifer J. , Berg Jason M. , Bergman Philip J. 
Published: August 2016

ABSTRACT
The prevalence of urinary tract infections (UTIs) in dogs with Type I intervertebral disc extrusion has been reported as high as 38% within 6 wk of surgery. Proper treatment of a UTI is important with myelopathy because it is a risk factor for persistent infection and reinfection in dogs. The study authors' investigated the incidence of UTIs in dogs having received either cefovecin or cefazolin as a preoperative prophylactic antibiotic for thoracolumbar hemilaminectomy. Thirty-nine dogs were retrospectively identified and assigned to groups based on preoperative antibiotic administration and postoperative urinary tract management. Urinalysis and urine culture performed preoperatively, at 2 wk, and at 6 wk, were reviewed to determine the incidence of UTIs. Urinary tract management, grade of neurologic deficit, time to ambulation, and time to voluntary urination were identified to evaluate for additional risk factors. No significant prevalence of UTI incidence was appreciated between the cefovecin and cefazolin groups. Patients with higher grades of neurologic deficit and that took longer to regain ambulation and voluntary urination were at significantly greater risk for UTIs throughout the postoperative period. This study reemphasizes the importance of continued surveillance for UTIs in patients with prolonged neurologic recovery.
Inherited platelet function disorders
Authors: Falcinelli Emanuela , Bury Loredana , Gresele Paolo 
Published: August 2016

SummaryInherited platelet function disorders (IPFDs) make up a significant proportion of congenital bleeding diatheses, but they remain poorly understood and often difficult to diagnose. Therefore, a rational diagnostic approach, based on a standardized sequence of laboratory tests, with consecutive steps of increasing level of complexity, plays a crucial role in the diagnosis of most IPFDs.In this review we discuss a diagnostic approach through platelet phenotyping and genotyping and we give an overview of the options for the management of bleeding in these disorders and an account of the few systematic studies on the bleeding risk associated with invasive procedures and its treatment.
Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A
Authors: Long Yan , Xu Miao , Li Rong , Dai Sheng , Beers Jeanette , Chen Guokai , Soheilian Ferri , Baxa Ulrich , Wang Mengqiao , Marugan Juan J. , Muro Silvia , Li Zhiyuan , Brady Roscoe , Zheng Wei 
Published: August 2016

Abstract
Niemann-Pick disease type A (NPA) is a lysosomal storage disease caused by mutations in the SMPD1 gene that encodes acid sphingomyelinase (ASM). Deficiency in ASM function results in lysosomal accumulation of sphingomyelin and neurodegeneration. Currently, there is no effective treatment for NPA. To accelerate drug discovery for treatment of NPA, we generated induced pluripotent stem cells from two patient dermal fibroblast lines and differentiated them into neural stem cells. The NPA neural stem cells exhibit a disease phenotype of lysosomal sphingomyelin accumulation and enlarged lysosomes. By using this disease model, we also evaluated three compounds that reportedly reduced lysosomal lipid accumulation in Niemann-Pick disease type C as well as enzyme replacement therapy with ASM. We found that α-tocopherol, δ-tocopherol, hydroxypropyl-β-cyclodextrin, and ASM reduced sphingomyelin accumulation and enlarged lysosomes in NPA neural stem cells. Therefore, the NPA neural stem cells possess the characteristic NPA disease phenotype that can be ameliorated by tocopherols, cyclodextrin, and ASM. Our results demonstrate the efficacies of cyclodextrin and tocopherols in the NPA cell-based model. Our data also indicate that the NPA neural stem cells can be used as a new cell-based disease model for further study of disease pathophysiology and for high-throughput screening to identify new lead compounds for drug development.

Significance
Currently, there is no effective treatment for Niemann-Pick disease type A (NPA). To accelerate drug discovery for treatment of NPA, NPA-induced pluripotent stem cells were generated from patient dermal fibroblasts and differentiated into neural stem cells. By using the differentiated NPA neuronal cells as a cell-based disease model system, α-tocopherol, δ-tocopherol, and hydroxypropyl-β-cyclodextrin significantly reduced sphingomyelin accumulation in these NPA neuronal cells. Therefore, this cell-based NPA model can be used for further study of disease pathophysiology and for high-throughput screening of compound libraries to identify lead compounds for drug development.
Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice
Authors: Hu Rong , Liu Yalan , Su Min , Song Yinhong , Rood Debra , Lai Laijun 
Published: August 2016

Abstract
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many malignant and nonmalignant diseases. However, chronic graft-versus-host disease (cGVHD) remains a significant cause of late morbidity and mortality after allogeneic HSCT. cGVHD often manifests as autoimmune syndrome. Thymic epithelial cells (TECs) play a critical role in supporting negative selection and regulatory T-cell (Treg) generation. Studies have shown that damage in TECs is sufficient to induce cGVHD. We have previously reported that mouse embryonic stem cells (mESCs) can be selectively induced to generate thymic epithelial progenitors (TEPs) in vitro. When transplanted in vivo, mESC-TEPs further develop into TECs that support T-cell development. We show here that transplantation of donor-origin mESC-TEPs into cGVHD recipients induces immune tolerance to both donor and host antigens and prevents the development of cGVHD. This is associated with more TECs and Tregs. Our results suggest that embryonic stem cell-derived TEPs may offer a new tool to control cGVHD.
Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-β1
Authors: Gimeno María L. , Fuertes Florencia , Barcala Tabarrozzi Andres E. , Attorressi Alejandra I. , Cucchiani Rodolfo , Corrales Luis , Oliveira Talita C. , Sogayar Mari C. , Labriola Leticia , Dewey Ricardo A. , Perone Marcelo J. 
Published: August 2016

AbstractAdult mesenchymal stromal cell-based interventions have shown promising results in a broad range of diseases. However, their use has faced limited effectiveness owing to the low survival rates and susceptibility to environmental stress on transplantation. We describe the cellular and molecular characteristics of multilineage-differentiating stress-enduring (Muse) cells derived from adipose tissue (AT), a subpopulation of pluripotent stem cells isolated from human lipoaspirates. Muse-AT cells were efficiently obtained using a simple, fast, and affordable procedure, avoiding cell sorting and genetic manipulation methods. Muse-AT cells isolated under severe cellular stress, expressed pluripotency stem cell markers and spontaneously differentiated into the three germ lineages. Muse-AT cells grown as spheroids have a limited proliferation rate, a diameter of ∼15 µm, and ultrastructural organization similar to that of embryonic stem cells. Muse-AT cells evidenced high stage-specific embryonic antigen-3 (SSEA-3) expression (∼60% of cells) after 7–10 days growing in suspension and did not form teratomas when injected into immunodeficient mice. SSEA-3+-Muse-AT cells expressed CD105, CD29, CD73, human leukocyte antigen (HLA) class I, CD44, and CD90 and low levels of HLA class II, CD45, and CD34. Using lipopolysaccharide-stimulated macrophages and antigen-challenged T-cell assays, we have shown that Muse-AT cells have anti-inflammatory activities downregulating the secretion of proinflammatory cytokines, such as interferon-γ and tumor necrosis factor-α. Muse-AT cells spontaneously gained transforming growth factor-β1 expression that, in a phosphorylated SMAD2-dependent manner, might prove pivotal in their observed immunoregulatory activity through decreased expression of T-box transcription factor in T cells. Collectively, the present study has demonstrated the feasibility and efficiency of obtaining Muse-AT cells that can potentially be harnessed as immunoregulators to treat immune-related disorders.
Magnetic Nanoparticle-Based Upregulation of B-Cell Lymphoma 2 Enhances Bone Regeneration
Authors: Brett Elizabeth , Zielins Elizabeth R. , Luan Anna , Ooi Chin Chun , Shailendra Siny , Atashroo David , Menon Siddarth , Blackshear Charles , Flacco John , Quarto Natalina , Wang Shan X. , Longaker Michael T. , Wan Derrick C. 
Published: August 2016

Abstract
Clinical translation of cell-based strategies for tissue regeneration remains challenging because survival of implanted cells within hostile, hypoxic wound environments is uncertain. Overexpression of B-cell lymphoma 2 (Bcl-2) has been shown to inhibit apoptosis in implanted cells. The present study describes an “off the shelf” prefabricated scaffold integrated with magnetic nanoparticles (MNPs) used to upregulate Bcl-2 expression in implanted adipose-derived stromal cells for bone regeneration. Iron oxide cores were sequentially coated with branched polyethyleneimine, minicircle plasmid encoding green fluorescent protein and Bcl-2, and poly-β-amino ester. Through in vitro assays, increased osteogenic potential and biological resilience were demonstrated in the magnetofected group over control and nucleofected groups. Similarly, our in vivo calvarial defect study showed that magnetofection had an efficiency rate of 30%, which in turn resulted in significantly more healing compared with control group and nucleofected group. Our novel, prefabricated MNP-integrated scaffold allows for in situ postimplant temporospatial control of cell transfection to augment bone regeneration.
Triwavelength synchronously mode-locked fiber laser based on few-layered black phosphorus
Authors: Zhao Ruwei , Li Jing , Zhang Baitao , Li Xiaowen , Su Xiancui , Wang Yiran , Lou Fei , Zhang Haikun , He Jingliang 
Published: August 2016

Abstract
A triwavelength synchronously mode-locked erbium-doped fiber laser with black phosphorus (BP) was demonstrated. The BP was proved to be not only an excellent saturable absorber (SA) but also a strong nonlinear material benefiting the stabilization of a multiwavelength fiber laser. The laser worked for a long time at three synchronous wavelengths of 1557.2, 1557.7, and 1558.2 nm. The autocorrelation trace of 9.41 ps pulses showed an interference beating of 0.06 THz, corresponding to a beating period of 16.37 ps. To the best of our knowledge, this is the first report on the usage of BP as an SA for building a multiwavelength synchronous mode-locked fiber laser.
LearningRx Cognitive Training Effects in Children Ages 8–14: A Randomized Controlled Trial
Authors: Carpenter Dick M. , Ledbetter Christina , Moore Amy Lawson 
Published: August 2016

SummaryIn a randomized controlled study, we examined the effects of a one‐on‐one cognitive training program on memory, visual and auditory processing, processing speed, reasoning, attention, and General Intellectual Ability (GIA) score for students ages 8–14. Participants were randomly assigned to either an experimental group to complete 60 h of cognitive training or to a wait‐list control group. The purpose of the study was to examine changes in multiple cognitive skills after completing cognitive training with ThinkRx, a LearningRx program. Results showed statistically significant differences between groups on all outcome measures except for attention. Implications, limitations, and suggestions for future research are examined. © 2016 The Authors Applied Cognitive Psychology Published by John Wiley & Sons Ltd.
Aminocatalytic Strategy for the Synthesis of Optically Active Benzothiophene Derivatives
Authors: Skrzyńska Anna , Albrecht Anna , Albrecht Łukasz 
Published: August 2016

AbstractA novel approach for the stereoselective synthesis of benzothiophene derivatives with a fused dihydropyran moiety is demonstrated. The reaction of 2‐alkylidenebenzothiophene‐3(2H)‐ones with dienamines derived from α,β‐unsaturated aldehydes and chiral secondary amines proceeds according to the inverse‐electron‐demand hetero‐Diels–Alder pathway. The formation of the aromatic benzothiophene moiety is a driving force for the developed reaction cascade. Target products bearing three adjacent stereogenic centers are obtained in excellent yields and in a highly stereoselective manner.magnified image
Rate Acceleration of Solid‐Liquid Phase‐Transfer Catalysis by Rotor‐Stator Homogenizer
Authors: Kano Taichi , Aota Yusuke , Maruoka Keiji 
Published: August 2016

AbstractA rotor‐stator homogenizer was found to be an effective mixing tool that accelerated solid‐liquid phase‐transfer reactions. In the asymmetric alkylation under phase‐transfer conditions using the homogenizer, a considerably high turnover frequency was observed.magnified image
Direct Synthesis of N‐Acyl‐N,O‐hemiacetals via Nucleophilic Addition of Unactivated Amides and Their O‐Acetylation: Access to α,α‐Difunctionalized N‐Acylimines
Authors: Asahara Haruyasu , Inoue Kanami , Tani Shinki , Umezu Kazuto , Nishiwaki Nagatoshi 
Published: August 2016

AbstractA mild, metal‐free synthesis of polyfunctionalized N‐acyl‐N,O‐hemiacetals was developed via the nucleophilic addition of unactivated amides to ketones. The protocol demonstrated a wide substrate scope, with good isolated yields. Additionally, their O‐acetylated products serve as a precursor of α,α‐difunctionalized N‐acylimines. An addition reaction of broad scope of nucleophiles to generate N‐acylimines is also reported.magnified image
Polymer Electrolyte Composite Membrane Based on Molecular Sieve 13X Mixed with Sulfonated Poly(ether ketone ether sulfone)/Poly(phenylene ether ether sulfone) Blended Membrane for Use in Direct Methanol Fuel Cell
Authors: Changkhamchom S. , Sirivat A. 
Published: August 2016

AbstractBlend membranes between sulfonated poly(ether ketone ether sulfone) (S‐PEKES) and poly(phenylene ether ether sulfone) (PPEES) were fabricated at various mole ratios. Interestingly, increasing the hydrophobic PPEES in S‐PEKES/PPEES blend membranes led to the decreases in water uptake (%) when compared to S‐PEKES. Incorporation of molecular sieve 13X drastically improved proton conductivity. Methanol permeability slightly decreased with molecular sieve 13X. The composite membrane with the 15% v/v molecular sieve 13X content showed the highest proton conductivity of 1.44 × 10−2 S/cm which is four times higher than Nafion 117. Thus, the blending between S‐PEKES and PPEES can help to decrease methanol permeability, and incorporating molecular sieve 13X can enhance proton conductivity.