bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large Scale Triboelectric Nanogenerator and Self-Powered Pressure Sensor Array Using Low Cost Roll-to-Roll UV Embossing
Authors: Dhakar Lokesh , Gudla Sudeep , Shan Xuechuan , Wang Zhiping , Tay Francis Eng Hock , Heng Chun-Huat , Lee Chengkuo 
Published: February 2016

AbstractTriboelectric nanogenerators (TENGs) have emerged as a potential solution for mechanical energy harvesting over conventional mechanisms such as piezoelectric and electromagnetic, due to easy fabrication, high efficiency and wider choice of materials. Traditional fabrication techniques used to realize TENGs involve plasma etching, soft lithography and nanoparticle deposition for higher performance. But lack of truly scalable fabrication processes still remains a critical challenge and bottleneck in the path of bringing TENGs to commercial production. In this paper, we demonstrate fabrication of large scale triboelectric nanogenerator (LS-TENG) using roll-to-roll ultraviolet embossing to pattern polyethylene terephthalate sheets. These LS-TENGs can be used to harvest energy from human motion and vehicle motion from embedded devices in floors and roads, respectively. LS-TENG generated a power density of 62.5 mW m−2. Using roll-to-roll processing technique, we also demonstrate a large scale triboelectric pressure sensor array with pressure detection sensitivity of 1.33 V kPa−1. The large scale pressure sensor array has applications in self-powered motion tracking, posture monitoring and electronic skin applications. This work demonstrates scalable fabrication of TENGs and self-powered pressure sensor arrays, which will lead to extremely low cost and bring them closer to commercial production.
Taste information derived from T1R-expressing taste cells in mice
Authors: Yoshida Ryusuke , Ninomiya Yuzo 
Published: February 2016

The taste system of animals is used to detect valuable nutrients and harmful compounds in foods. In humans and mice, sweet, bitter, salty, sour and umami tastes are considered the five basic taste qualities. Sweet and umami tastes are mediated by G-protein-coupled receptors, belonging to the T1R (taste receptor type 1) family. This family consists of three members (T1R1, T1R2 and T1R3). They function as sweet or umami taste receptors by forming heterodimeric complexes, T1R1+T1R3 (umami) or T1R2+T1R3 (sweet). Receptors for each of the basic tastes are thought to be expressed exclusively in taste bud cells. Sweet (T1R2+T1R3-expressing) taste cells were thought to be segregated from umami (T1R1+T1R3-expressing) taste cells in taste buds. However, recent studies have revealed that a significant portion of taste cells in mice expressed all T1R subunits and responded to both sweet and umami compounds. This suggests that sweet and umami taste cells may not be segregated. Mice are able to discriminate between sweet and umami tastes, and both tastes contribute to behavioural preferences for sweet or umami compounds. There is growing evidence that T1R3 is also involved in behavioural avoidance of calcium tastes in mice, which implies that there may be a further population of T1R-expressing taste cells that mediate aversion to calcium taste. Therefore the simple view of detection and segregation of sweet and umami tastes by T1R-expressing taste cells, in mice, is now open to re-examination.
Non-mereological pluralistic supersubstantivalism: an alternative perspective on the matter/spacetime relationship
Authors: Dumsday Travis 
Published: February 2016

AbstractIn both the historical and contemporary literature on the metaphysics of space (and, more recently, spacetime), a core dispute is that between relationism and substantivalism. One version of the latter is supersubstantivalism, according to which space (or, again, spacetime) is the only kind of substance, such that what we think of as individual material objects (electrons, quarks, etc.) are actually just parts of spacetime which instantiate certain properties. If those parts are ontologically dependent on spacetime as a whole, then we arrive at an ontology with only a single genuinely independent substance, namely the entire spacetime manifold. This is monist supersubstantivalism. A view on which the parts of spacetime are ontologically prior to the whole has been called pluralistic supersubstantivalism. As currently formulated, supersubstantivalism (in either its monist or pluralistic forms) carries significant advantages and encounters major difficulties. I argue that some of the latter motivate an alternative formulation, non-mereological pluralistic supersubstantivalism, according to which spacetime is a real substance, but what we think of as material objects are also real substances, irreducible to and numerically distinct from that larger spacetime manifold and any of its parts. Yet, the underlying nature of those material objects is ultimately the same type as that of spacetime: at bottom, a particle is just a smaller quantity of spacetime embedded in or contained by or co-located with the larger whole that we would normally think of as ‘spacetime, ’ capable both of genuine movement within/across the larger spacetime manifold and (at least in principle) independent existence from it.
The role of a vertical reference point in changing gait regulation in cricket run‐ups
Authors: Greenwood Daniel , Davids Keith , Renshaw Ian 
Published: February 2016

AbstractThe need to identify information sources which facilitate a functional coupling of perception and action in representative practice contexts is an important challenge for sport scientists and coaches. The current study investigated the role of visual information in regulating athlete gait behaviours during a locomotor pointing task in cricket. Integration of experiential knowledge of elite coaches and theoretical understanding from previous empirical research led us to investigate whether the presence of an umpire would act as a vertical informational constraint that could constrain the emergent coordination tendencies of cricket bowlers’ run‐up patterns. To test this idea, umpire presence was manipulated during run‐ups of 10 elite medium‐fast bowlers. As hypothesised, removal of the umpire from the performance environment did not result in an inability to regulate gait to intercept a target, however, the absence of this informational constraint resulted in the emergence of different movement patterns in participant run‐ups. Significantly lower standard deviation values of heel‐to‐crease distances were observed in the umpire condition at multiple steps, compared to performance in the no‐umpire condition. Manipulation of this informational constraint altered gait regulation of participants, offering a mechanism to understand how perception–action couplings can be varied during performance in locomotor pointing tasks in sport.
Association Between Blood Pressure and Adherence to French Dietary Guidelines
Authors: Lelong Helene , Blacher Jacques , Menai Mehdi , Galan Pilar , Fezeu Leopold , Hercberg Serge , Kesse-Guyot Emmanuelle 
Published: February 2016

Abstract

BACKGROUND
Adopting a healthy diet like the Dietary Approach to Stop Hypertension (DASH) or Mediterranean diet (MD) represents a major lifestyle for blood pressure (BP) control in general population. Nutritional policies, such as the French Nutrition and Health Program ( Programme National Nutrition Santé or PNNS), have been implemented in several countries with the aims of preventing chronic diseases. The objective of our study was to investigate association between BP and adherence to PNNS guidelines compared with adherence to DASH or MD.

METHODS
We conducted a cross-sectional study in 11,302 untreated participants from the NutriNet-Santé study, a French web-based cohort study. Three validated scores reflecting adherence to PNNS guidelines, DASH diet, and MD were calculated from repeated 24-hour records. Three BP measurements using a standardized protocol were collected. Multivariate linear models were used to assess the associations between the dietary scores and BP.

RESULTS
In women, independent of age, socioeconomic status, body mass index, tobacco use, alcohol consumption, and physical activity, adherence to PNNS guidelines was inversely significantly associated with systolic BP (β = −0.63, P &lt; 0.0001). This association was of similar amplitude that between BP and adherence to DASH-style diet (β = −0.66, P &lt; 0.0001) or MD (β = −0.63, P = 0.0002). No significant association was found in men.

CONCLUSION
Adherence to French nutritional recommendations was found negatively associated with BP at the same magnitude as adherence to well-known dietary pattern in the prevention and treatment of hypertension.
OpenSegSPIM: a user-friendly segmentation tool for SPIM data
Authors: Gole Laurent , Ong Kok Haur , Boudier Thomas , Yu Weimiao , Ahmed Sohail 
Published: February 2016

Abstract
Summary: OpenSegSPIM is an open access and user friendly 3D automatic quantitative analysis tool for Single Plane Illumination Microscopy data. The software is designed to extract, in a user-friendly way, quantitative relevant information from SPIM image stacks, such as the number of nuclei or cells. It provides quantitative measurement (volume, sphericity, distance, intensity) on Light Sheet Fluorescent Microscopy images.
Availability and implementation: freely available from http://www.opensegspim.weebly.com. Source code and binaries under BSD License.
Contact: lgole@imcb.a-star.edu.sg or wmyu@imcb.a-star.edu.sg or sohail.ahmed@imb.a-star.edu.sg
Supplementary information: Supplementary data are available at Bioinformatics online.
Are the hosts of VLBI-selected radio-AGN different to those of radio-loud AGN?
Authors: Rees G. A. , Norris R. P. , Spitler L. R. , Herrera-Ruiz N. , Middelberg E. 
Published: February 2016

Abstract
Recent studies have found that radio-AGN selected by radio-loudness show little difference in terms of their host galaxy properties when compared to non-AGN galaxies of similar stellar mass and redshift. Using new 1.4 GHz very long baseline interferometry (VLBI) observations of the Cosmological Evolution Survey field, we find that approximately 49 ± 8 per cent of high-mass (M &gt; 1010.5 M⊙), high-luminosity (L1.4 &gt; 1024 W Hz−1) radio-AGN possess a VLBI-detected counterpart. These objects show no discernible bias towards specific stellar masses, redshifts or host properties other than what is shown by the radio-AGN population in general. Radio-AGN that are detected in VLBI observations are not special, but form a representative sample of the radio-loud AGN population.
Cutaneous PEComas Express CD10: Implications for the Classification of PEComas and the Differential Diagnosis With Metastatic Renal Cell Carcinoma
Authors: Fernandez-Flores Angel , Nguyen Catherine M. , Cassarino David S. 
Published: February 2016

Abstract:
Cutaneous perivascular epithelioid cell tumors (PEComas) are peculiar, rare mesenchymal tumors of uncertain lineage. They show a characteristic epithelioid morphology, and they are usually composed of monomorphous clear-to-granular appearing perivascular cells. One of the main differential diagnoses with PEComas is a cutaneous metastasis from renal cell carcinoma (RCC). CD10 has been emphasized to be a crucial marker in the diagnosis of metastasis from RCC. Although visceral PEComas have been studied for CD10 expression, primary cutaneous PEComas have not. Although it could be assumed a priori that cutaneous PEComas would stain as their visceral counterpart, there is increasing evidence that cutaneous PEComas could actually be unrelated to PEComas from other organs. In this report, the author's studied three primary cutaneous PEComas, and included CD10 in our immunohistochemical studies. All three PEComas expressed the marker. They conclude that a CD10+ clear-cell dermal tumor is not necessarily equivalent to a metastasis from RCC and that additional stains should be added to rule out PEComa, even if the biopsy or the panel of antibodies is limited.
Cellular Blue Nevomelanocytic Lesions: Analysis of Clinical, Histological, and Outcome Data in 37 Cases
Authors: Hung Tawny , Argenyi Zsolt , Erickson Lori , Guitart Joan , Horenstein Marcelo G. , Lowe Lori , Messina Jane , Piepkorn Michael W. , Prieto Victor G. , Rabkin Michael S. , Schmidt Birgitta , Selim Maria A. , Shea Christopher R. , Trotter Martin J. , Barnhill Raymond L. 
Published: February 2016

Abstract:
Cellular blue nevomelanocytic lesions (CBNLs) frequently pose diagnostic problems to pathologists, and their biological potential may be difficult to establish. In this study, the authors have analyzed the clinical, histological, and outcome data of 37 cellular blue nevomelanocytic lesions and the molecular characteristics of 4 lesions. The cohort of cases comprised 8 cellular blue nevi (CBNs), 17 atypical cellular blue nevi (ACBNs), and 12 blue-nevus–like melanomas (BNLMs) with a mean follow-up of 5 years. The average age at diagnosis was 25.9 years for patients with ACBN, versus 30.4 years for CBN, and 44.6 years for BNLM. Both CBN and ACBN occurred most frequently on the trunk or extremities, whereas BNLM primarily involved the scalp. Histologically, CBN and ACBN were characterized by a mean diameter of <1 cm, absence of necrosis, low mitotic rate (mean: 1–2 mitotic figures/mm2), little or no infiltrative properties, and usually low-grade cytologic atypia. In contrast, BNLM had a mean diameter of 1.6 cm, necrosis, tissue infiltration, greater mitotic activity (mean: 6 mitotic figures/mm2), and high-grade cytologic atypia. ACBNs often were larger, more densely cellular, exhibited higher mitotic counts, and were cytologically more atypical than CBN. Seven CBN cases with follow-up had a benign clinical course (average follow-up of 4.7 years). Among 6 patients with ACBN who underwent sentinel lymph node (SLN) biopsy, 3 were positive, and a single additional case had 1 positive non-SLN (this patient did not have a SLN biopsy performed). All 14 cases of ACBN with follow-up were alive and without recurrence with mean follow-up of 5 years. Of the 9 melanoma cases with follow-up, 3 patients with SLN and non-SLN involvement died from their disease (average follow-up of 4.8 years). Array comparative genomic hybridization was performed on 2 ACBNs and 1 BNLM: One of the 2 ACBNs showed chromosomal aberrations and 1 BNLM showed multiple chromosomal gains and losses. Multiplex polymerase chain reaction was performed on 1 ACBN, and no mutations were found. From these results, the authors conclude that ACBN occupy an intermediate position within the spectrum of CBN and BNLM, yet many lesions cannot be reliably distinguished from either CBN or BNLM because of overlapping histologic features. However, in general, ACBNs seem to aggregate more closely with CBN in terms of clinical, histological, molecular profile (limited data), and biological behavior.
ERG Is a Useful Immunohistochemical Marker to Distinguish Leukemia Cutis From Nonneoplastic Leukocytic Infiltrates in the Skin
Authors: Xu Bin , Naughton Daisy , Busam Klaus , Pulitzer Melissa 
Published: February 2016

Abstract:Leukemia cutis (LC) and reactive myeloid infiltrates in the skin may be difficult to distinguish pathologically, sometimes even after an extensive immunohistochemical work-up. This poses a serious clinical dilemma, as the prognosis and treatment of either condition are markedly different. Although most reactive myeloid infiltrates require a simple course of corticosteroids before the symptoms regress, the development of LC may require chemotherapeutic or transplant-variant interventions. Erythroblast transformation specific regulated gene-1 (ERG) is a member of the erythroblast transformation specific family of transcription factors, which are downstream effectors of mitogenic signaling transduction pathways. ERG is a key regulator of cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis and has recently been found to be overexpressed in acute myeloid and lymphoblastic leukemia. In this study, the authors aimed to explore the diagnostic utility of ERG immunohistochemistry in LC by comparing the frequency and expression level of ERG immunostain in 32 skin biopsies, 16 with LC and 16 with reactive leukocytic infiltrates. A significantly higher frequency of ERG positivity was detected in LC (13/16, 81.4%), compared with reactive conditions (0/16). In addition, the expression level of ERG in LC, calculated using H score (mean ± standard error of mean, 188 ± 24), was significantly higher than that in nonneoplastic leukocytic infiltrate (28 ± 8). Our results strongly suggest that ERG expression is potentially an extremely useful marker to distinguish between cases of LC from those of reactive myeloid infiltrates in the skin with a positive predictive value of 100% and negative predictive value of 84.2%.
Thoracoscopic Ablation with Appendage Ligation versus Medical Therapy for Stroke Prevention a Proof-of-Concept Randomized Trial
Authors: Beaver Thomas M. , Hedna Vishnumurthy Shushrutha , Khanna Anna Y. , Miles William M. , Price Catherine C. , Schmalfuss Ilona M. , Aalaei-Andabili Seyed Hossein , Waters Michael F. 
Published: February 2016

Objective Atrial fibrillation (AF) has a demonstrable effect on quality of life (QOL). Recurrent stroke occurs in 10% of patients with AF. The objective of this study was to demonstrate proof of concept that thoracoscopic pulmonary vein isolation and atrial appendage ligation (TPVIAL) could prevent recurrent stroke and could potentially improve QOL in patients with AF with a previous stroke. Methods The study was a National Institutes of Health-funded single-center proof-of-concept design that randomized 23 patients with AF-related stroke to TPVIAL (n = 12) or to medical management (n = 11). Quality of life was the primary outcome variable; secondary end points included restoration of rhythm, recurrent stroke, and surgical morbidity. Results Quality-of-life subscores at 3 and 6 months revealed improvements in energy and decreases in fatigue in the TPVIAL arm [baseline, 33 (19.8); 3 months, 49.5 (20.6), P = 0.01; 6 months, 55.5 (14.4), P = 0.03]. At 12-month follow-up, there were no recurrent strokes in the TPVIAL group. In the medically treated arm, two patients at 6 months (P = 0.22) and three total patients at 12 months (P = 0.09) had recurrent ischemic stroke. There was one death in the medical management arm. In the TPVIAL arm, no AF recurrence occurred in patients with paroxysmal AF, and one patient had recurrence of persistent and long-standing AF. Seven patients in the TPVIAL arm discontinued warfarin therapy for secondary stroke prevention. Conclusions This small proof-of-concept study showed that TPVIAL improved QOL on two subscores and restored normal sinus rhythm in all but one patient, and it showed the potential to prevent secondary stroke. A larger study will be needed.
Heat Vulnerability Index Mapping for Milwaukee and Wisconsin
Authors: Christenson Megan , Geiger Sarah Dee , Phillips Jeffrey , Anderson Ben , Losurdo Giovanna , Anderson Henry A. 
Published: February 2016

Context:
Extreme heat waves elevate the population's risk for heat-related morbidity and mortality, specifically for vulnerable groups such as older adults and young children. In this context, we developed 2 Heat Vulnerability Indices (HVIs), one for the state of Wisconsin and one for the Milwaukee metropolitan area.

Objective:
Through the creation of an HVI, state and local agencies will be able to use the indices as a planning tool for extreme heat events.

Design:
Data used for the HVIs were grouped into 4 categories: (1) population density; (2) health factors; (3) demographic and socioeconomic factors; and (4) natural and built environment factors. These categories were mapped at the Census block group level.

Main Outcome Measures:
Unweighted z-score data were used to determine index scores, which were then mapped by quantiles ranging from “high” to “low” vulnerability.

Results:
Statewide, Menominee County exhibited the highest vulnerability to extreme heat. Milwaukee HVI findings indicated high vulnerability in the city's inner core versus low vulnerability along the lakeshore.

Conclusion:
Visualization of vulnerability could help local public health agencies prepare for future extreme heat events.
Who Participates in Building Disaster Resilient Communities: A Cluster-Analytic Approach
Authors: Adams Rachel M. , Rivard Helene , Eisenman David P. 
Published: February 2016

Context:
The Los Angeles County Community Disaster Resilience project is a community-based program to improve disaster resilience. We collected baseline measures of resilience-related attitudes and practices among targeted communities prior to the implementation of the intervention.

Objectives:
This study identified community disaster resilience behavior patterns and assessed their associations with sociodemographic and social cognitive characteristics.

Design:
Telephone surveys during summer 2013.

Setting:
Sixteen communities in Los Angeles County (2 per service planning area).

Participants:
The address-based sample of adults (≥18) was selected to be representative of 2010 census tracts in each of the communities

Main Outcome Measures:
We examined relationships between sociodemographic characteristics, social cognitive factors, and participation in community disaster resilience activities.

Results:
Three clusters of community resilience behavior patterns emerged. Cluster distribution significantly differed across several sociodemographic and social cognitive factors. Participants who were African American, Hispanic, had higher education, income, self-efficacy, trust in the public health department, civic engagement, and social capital were significantly associated with being in the cluster most active in resilience-building activities.

Conclusions:
The results confirm that there are distinct community resilience behavior patterns. These patterns vary according to population characteristics, which supports audience segmentation approaches and developing a range of emergency preparedness programs targeted to the strengths and weaknesses of the different audience segments.
Evaluating the Quality and Usability of Open Data for Public Health Research: A Systematic Review of Data Offerings on 3 Open Data Platforms
Authors: Martin Erika G. , Law Jennie , Ran Weijia , Helbig Natalie , Birkhead Guthrie S. 
Published: February 2016

Context:
Government datasets are newly available on open data platforms that are publicly accessible, available in nonproprietary formats, free of charge, and with unlimited use and distribution rights. They provide opportunities for health research, but their quality and usability are unknown.

Objective:
To describe available open health data, identify whether data are presented in a way that is aligned with best practices and usable for researchers, and examine differences across platforms.

Design:
Two reviewers systematically reviewed a random sample of data offerings on NYC OpenData (New York City, all offerings, n = 37), Health Data NY (New York State, 25% sample, n = 71), and HealthData.gov (US Department of Health and Human Services, 5% sample, n = 75), using a standard coding guide.

Setting:
Three open health data platforms at the federal, New York State, and New York City levels.

Main Outcome Measures:
Data characteristics from the coding guide were aggregated into summary indices for intrinsic data quality, contextual data quality, adherence to the Dublin Core metadata standards, and the 5-star open data deployment scheme.

Results:
One quarter of the offerings were structured datasets; other presentation styles included charts (14.7%), documents describing data (12.0%), maps (10.9%), and query tools (7.7%). Health Data NY had higher intrinsic data quality (P < .001), contextual data quality (P < .001), and Dublin Core metadata standards adherence (P < .001). All met basic “web availability” open data standards; fewer met higher standards of “hyperlinked to other data.”

Conclusions:
Although all platforms need improvement, they already provide readily available data for health research. Sustained effort on improving open data websites and metadata is necessary for ensuring researchers use these data, thereby increasing their research value.