bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
Authors: Demaria Marco , O'Leary Monique N. , Chang Jianhui , Shao Lijian , Liu Su , Alimirah Fatouma , Koenig Kristin , Le Catherine , Mitin Natalia , Deal Allison M. , Alston Shani , Academia Emmeline C. , Kilmarx Sumner , Valdovinos Alexis , Wang Boshi , de Bruin Alain , Kennedy Brian K. , Melov Simon , Zhou Daohong , Sharpless Norman E. , Muss Hyman , Campisi Judith 
Published: December 2016

Abstract
Cellular senescence suppresses cancer by irreversibly arresting cell proliferation. Senescent cells acquire a proinflammatory senescence-associated secretory phenotype. Many genotoxic chemotherapies target proliferating cells nonspecifically, often with adverse reactions. In accord with prior work, we show that several chemotherapeutic drugs induce senescence of primary murine and human cells. Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist and contribute to local and systemic inflammation. Eliminating TIS cells reduced several short- and long-term effects of the drugs, including bone marrow suppression, cardiac dysfunction, cancer recurrence, and physical activity and strength. Consistent with our findings in mice, the risk of chemotherapy-induced fatigue was significantly greater in humans with increased expression of a senescence marker in T cells prior to chemotherapy. These findings suggest that senescent cells can cause certain chemotherapy side effects, providing a new target to reduce the toxicity of anticancer treatments.
Significance: Many genotoxic chemotherapies have debilitating side effects and also induce cellular senescence in normal tissues. The senescent cells remain chronically present where they can promote local and systemic inflammation that causes or exacerbates many side effects of the chemotherapy. Cancer Discov; 7(2); 165–76. ©2016 AACR.
This article is highlighted in the In This Issue feature, p. 115
Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension
Authors: Temple Ian P. , Logantha Sunil Jit R.J. , Absi Mais , Zhang Yu , Pervolaraki Eleftheria , Yanni Joseph , Atkinson Andrew , Petkova Maria , Quigley Gillian M. , Castro Simon , Drinkhill Mark , Schneider Heiko , Monfredi Oliver , Cartwright Elizabeth , Zi Min , Yamanushi Tomoko T. , Mahadevan Vaikom S. , Gurney Alison M. , White Ed , Zhang Henggui , Hart George , Boyett Mark R. , Dobrzynski Halina 
Published: December 2016

Background—
Heart block is associated with pulmonary hypertension, and the aim of the study was to test the hypothesis that the heart block is the result of a change in the ion channel transcriptome of the atrioventricular (AV) node.

Methods and Results—

The most commonly used animal model of pulmonary hypertension, the monocrotaline-injected rat, was used. The functional consequences of monocrotaline injection were determined by echocardiography, ECG recording, and electrophysiological experiments on the Langendorff-perfused heart and isolated AV node. The ion channel transcriptome was measured by quantitative PCR, and biophysically detailed computer modeling was used to explore the changes observed. After monocrotaline injection, echocardiography revealed the pattern of pulmonary artery blood flow characteristic of pulmonary hypertension and right-sided hypertrophy and failure; the Langendorff-perfused heart and isolated AV node revealed dysfunction of the AV node (eg, 50% incidence of heart block in isolated AV node); and quantitative PCR revealed a widespread downregulation of ion channel and related genes in the AV node (eg, >50% downregulation of Ca
v
1.2/3 and HCN1/2/4 channels). Computer modeling predicted that the changes in the transcriptome if translated into protein and function would result in heart block.

Conclusions—
Pulmonary hypertension results in a derangement of the ion channel transcriptome in the AV node, and this is the likely cause of AV node dysfunction in this disease.
Clinical and Epidemiological Implications of 24‐Hour Ambulatory Blood Pressure Monitoring for the Diagnosis of Hypertension in Kenyan Adults: A Population‐Based Study
Authors: Etyang Anthony O. , Warne Ben , Kapesa Sailoki , Munge Kenneth , Bauni Evasius , Cruickshank J. Kennedy , Smeeth Liam , Scott J. Anthony G. 
Published: December 2016

Background

The clinical and epidemiological implications of using ambulatory blood pressure monitoring (
ABPM
) for the diagnosis of hypertension have not been studied at a population level in sub‐Saharan Africa. We examined the impact of
ABPM
use among Kenyan adults.

Methods and Results

We performed a nested case–control study of diagnostic accuracy. We selected an age‐stratified random sample of 1248 adults from the list of residents of the Kilifi Health and Demographic Surveillance System in Kenya. All participants underwent a screening blood pressure (BP) measurement. All those with screening
BP
≥140/90 mm Hg and a random subset of those with screening
BP
<140/90 mm Hg were invited to undergo
ABPM
. Based on the 2 tests, participants were categorized as sustained hypertensive, masked hypertensive, “white coat” hypertensive, or normotensive. Analyses were weighted by the probability of undergoing
ABPM
. Screening
BP
≥140/90 mm Hg was present in 359 of 986 participants, translating to a crude population prevalence of 23.1% (95%
CI
16.5–31.5%). Age standardized prevalence of screening
BP
≥140/90 mm Hg was 26.5% (95% CI 19.3–35.6%). On
ABPM
, 186 of 415 participants were confirmed to be hypertensive, with crude prevalence of 15.6% (95% CI 9.4–23.1%) and age‐standardized prevalence of 17.1% (95% CI 11.0–24.4%). Age‐standardized prevalence of masked and white coat hypertension were 7.6% (95% CI 2.8–13.7%) and 3.8% (95% CI 1.7–6.1%), respectively. The sensitivity and specificity of screening
BP
measurements were 80% (95% CI 73–86%) and 84% (95% CI 79–88%), respectively.
BP
indices and validity measures showed strong age‐related trends.

Conclusions

Screening
BP
measurement significantly overestimated hypertension prevalence while failing to identify ≈50% of true hypertension diagnosed by
ABPM
. Our findings suggest significant clinical and epidemiological benefits of
ABPM
use for diagnosing hypertension in Kenyan adults.
The Novelist as Organic Intellectual: William Hill Brown’sThe Power of Sympathy, Reconsidered
Authors: Lawrimore David 
Published: December 2016

AbstractScholars of material and print culture have recently challenged the theory of an early American public sphere, arguing that the literary landscape of eighteenth-century America was composed instead of fragmented publics, local networks frequently partisan in nature. This essay theorizes how the novel genre functions within these publics by reconsidering the literary career of William Hill Brown, best known as the author of The Power of Sympathy (1789). Reading his lesser-known writings, I argue that Brown was an intellectual for a prominent network—often referred to as the natural aristocracy—and saw the novel genre as a means to disperse his network’s ideology to a growing novel-reading audience. I conclude by reevaluating The Power of Sympathy in light of Brown’s commitment to the natural aristocracy, which provides a model for considering the novel genre within the framework of local publics rather than as part of a universal public sphere.
Foot and ankle tendoscopies: current concepts review
Authors: Monteagudo Manuel , Maceira Ernesto , Martinez de Albornoz Pilar 
Published: December 2016

Tendoscopy is an apparently safe and reliable procedure to manage some foot and ankle disorders. The most common foot and ankle tendoscopies are: Achilles; peroneal; and posterior tibial tendon. Tendoscopy may be used as an adjacent procedure to other techniques. Caution is recommended to avoid neurovascular injuries. Predominantly level IV and V studies are found in the literature, with no level I studies still available. There are many promising and evolving endoscopic techniques for tendinopathies around the foot and ankle, but studies of higher levels of evidence are needed to strongly recommend these procedures. Cite this article: EFORT Open Rev 2016;1:440-447. DOI: 10.1302/2058-5241.160028
Investigation of burnout level of sport faculty students
Authors: Yalçın İlimdar , Gacar Atalay 
Published: December 2016

The aim of this study is to investigate burnout level of last class sport faculty students. Our study was conducted on total 213 voluntary senior students who study Physical Education and Sports Teaching at Sakarya University Faculty of Sports Sciences, Firat University Faculty of Sports Sciences, Dumlupinar University School of Physical Education and Sports, Bartin University School of Physical Education and Sports, and Yuzuncu Yil University School of Physical Education and Sports. A personal information form and the Schaufeli, Leiter, Maslach and Jackson (1996) burnout scale was used. adaptation of burnout scale to Turkish made by Schaufeli, Martinez, Marques-Pinto, Salanova and Bakker (2002). A new adaptation form of burnout scale made by Capri, Gunduz ve Gokcakan (2011) for the students which composed of 13 questions. for the anaylises microsoft windows and SPSS 22 packet program was used. In the study, Cronbach’s Alpha was found as 0.78.As a result, a significant changes has been found between last class students gender and depersonalization subdemension. the depersonalization level of male students found more than female students. Statistically a significant relation has been found between age and exhaustion subdimension. Also there is significant differences between students who plan to receive postgraduate education and both exhausted and depersonalization subdemension.
Lingering nomad ideology in 21st century Mongolia
Authors: Szilágyi Zsolt 
Published: December 2016

A specific economic and social realignment can be observed in Mongolia nowadays. Due to the rapid transformation in the last two and a half decades, the mentality and way of life of Mongolian people have also changed to a great degree and a specific national or nomadic ideology has appeared and gradually strengthened, which has become one of the pillar of national identity. This ideology is shared in many respects by Mongolians, living not only in Mongolia, but China and Inner Asia too.
In the economic environment the Mongolian society is changing at an accelerated speed. The urban population is getting far from the nomadic way of life and has started to follow behavioural models that are very different from the traditional patterns. With the regression of nomadism one of the fundamental constituents of the Mongolian culture seems to disappear. Although in the last 25 years Mongolians have increasingly adapted to the globalized culture, the tradition of Genghis has not totally vanished, what is more, nowadays it revives. The need for independent cultural identity is getting stronger. It plays a role in elaborating economic strategies that are adaptable to the changed environment. It can be observed, for example, in turnout of shamans in the towns, in the changes of the Buddhist Church’s social functions or in the “pretended” nomadic lifestyle around the main destination of tourism.
Pokolenie Jana Pawła II. Kim są ci ludzie i jaka jest ich rola w Kościele?
Authors: Borutka Tadeusz 
Published: December 2016

Od pewnego czasu pojawia się w przestrzeni publicznej określenie „pokolenie Jana Pawła II”. W związku z tym zasadne okazuje się podjęcie tego zagadnienia oraz ukazanie jego znaczenia dla rozwoju Kościoła we współczesnym świecie. W dobie nowej ewangelizacji ważne jest zaangażowanie się wszystkich ludzi wierzących w rozwój Kościoła, a szczególnie związanych ze św. Janem Pawłem II. Są to bowiem ludzie ukształtowani przez niego i naśladujący go w postępowaniu.
Komunikacja z pacjentem chorym na Alzheimera
Authors: Kamanová Irena 
Published: December 2016

Według statystyk obecnie na świecie żyje 36 milionów ludzi, których dosięgła demencja typu alzheimerowskiego. Częstość występowania choroby zwiększa się z wiekiem. Według Organizacji do spraw Alzheimera na Słowacji w 2010 roku na Słowacji było około 60 tys. pacjentów chorych na Alzheimera oraz inne, pokrewne choroby. Szacuje się, że w 2030 roku liczba ta wzrośnie do 180 tys. pacjentów. Choroba ta wpływa również na dziesiątki tysięcy opiekunów i członków rodziny, którzy opiekują się chorymi. Dlatego też koniecznym jest, aby społeczeństwo reagowało na taką sytuację. Ludzie proponujący usługi socjalne muszą się profesjonalnie przygotować do pracy z tego typu pacjentem.
Education to the “integral ecology”. Focus on the social teaching of Pope Francis and his encyclical „Laudato si’”
Authors: Szułczyński Andrzej 
Published: December 2016

The intention of the author of this article is a presentation of the social teaching of Pope Francis on the basis of his green encyclical related primarily to human ecology and environmental ecology, forming both in every family and then at school and university by the media and culture. Education in ‘integral ecology’ is intended to be sensitive to the various aspects of ecology and consequently the protection of human and social life against environmental degradation. Education is a long term process and therefore is concerned about an intergenerational ‘Common Home’, so it cannot be ignored by macro and micro structures of economy or ecology. Pope Francis indicates the correlation between ecology and economy, between environmental ecology and the ecology of man (human ecology) and above all, his moral condition. Social and economic systems must remain on guard to ensure that the balance between the biological and the ecosystem has been properly preserved. In the social assessment and analysis, Pope Francis criticises globalisation, neo­‑liberalism as a form of a new colonialism providing false ecology in economy and in a global politics ultimately directed against developing countries and the poor and excluded. Therefore education which begins in the family has to take into account the problems of ecological crisis and the crisis of ecology of man and his moral condition. The social teaching of Pope Francis shows, as never before, the close relationship between economy, ecology and social ethics.
Conciencia política de las mujeres durante la independencia de Nueva Granada. El caso de Santafé entre 1810 y 1820
Authors: Serrano Galvis Ana 
Published: December 2016

<p><strong></strong>Este artículo se pregunta por el significado que tuvo para las mujeres el proceso de independencia de Nueva Granada, específicamente en la ciudad capital de Santafé entre 1810 y 1820. Para captarlo se vale del concepto de conciencia política, que entiende lo político más allá del apoyo explícito a una causa o bando políticos, permitiendo la inclusión de aquellas mujeres que no tomaron partido y simplemente se adaptaron a las circunstancias que les tocó vivir. Posteriormente, analiza la forma en que se manifestó la conciencia política de las mujeres en relación con el comportamiento correcto o incorrecto de las autoridades y a las propuestas de las distintas facciones políticas que disputaron el poder. Como hipótesis se propone que las mujeres, además de participar activamente en eventos y movimientos políticos, también participaron activamente de la cultura política de la época y contribuyeron a su constante redefinición</p><p> </p>
Los misterios urbanos en el mundo: circulación, transferencias, apropiaciones
Authors: Thérenty Marie-Eve 
Published: December 2016

<p>En este estudio se aborda un ejemplo de la primera globalización de la cultura a partir de <em>Los misterios de París</em>, de Eugène Sue –publicados originalmente por entregas en el <em>Journal des Débats</em>, entre junio de 1842 y octubre de 1843–, que representa el inicio de los llamados misterios urbanos. La novela <em>Los misterios de París</em>, cuestiona aspectos relacionados con la modernidad de la ciudad, al mostrar, entre otros aspectos, el crimen, el tejido social, lo misterioso. El misterio urbano se reprodujo en distintos países, lo que habla de la circulación y apropiación de la novela de Sue. De ahí que se plantee la necesidad de estudiar los soportes con un enfoque transnacional de las literaturas. Con base en los resultados de las indagaciones emprendidas por el proyecto de investigación colectivo, interinstitucional e internacional Médias 19, es posible proponer algunas hipótesis sobre las leyes que rigen en la república mundial de las letras, como son: La ley de la transferencia: no hay transferencia sin mutación; Instantaneidad y desfase; La ley de la hibridación.</p><p> </p>
Digital Forensic Science: A Manifesto
Authors: Olivier Martin S 
Published: December 2016

Forensic examination of evidence holds the promise of making claims about the truth of certain propositions with the inherent accuracy
and reliability that characterises scientific endeavours. The propositions may relate to the artefacts examined or related artefacts. The
nature of propositions about which claims can be made depend on the extent to which given propositions fall within the ambit of scientific
knowledge and on the extent to which the examined evidence is suitable for the application of established science. A continuing series
of incidents illustrate that in many forensic disciplines that promise is not met — often because some branch of forensic science happen
to not being scientific at all. In fact, serious assessments of forensic science have shown that many (if not most) branches of forensic
science are not scientifically valid.
Digital forensic science is one of the newest members of the family of forensic sciences. A number of reasons for concern exist that
it is following in the footsteps of its more established footsteps and repeating many of the mistakes of those other branches of forensic
science.
This viewpoint is written in the form of a manifesto that is situated in the current discourse about digital forensic science and practice.
If challenges the current developments in digital forensic science by positing a number of demands that digital forensic science have to
meet to be deemed scientific. The demands are posited as necessary, but not sufficient to ensure that digital forensic science uses science
to contribute to justice. Appropriate responses to the manifesto is a change in digital forensic developments or an informed debate about
the issues raised in the manifesto.
A propósito de una nueva clasificación del embarazo a término. Resultados neonatales en una clínica de tercer nivel de atención en Cali, Colombia. Un estudio de corte transversal, 2013
Authors: Cifuentes-Borrero Rodrigo , Hernández-Carrillo Mauricio , Toro-Cifuentes Ana María , Franco-Torres Viviana R. , Cubides-Munevar Ángela M. , Duarte-González Ingrid J. 
Published: December 2016

<p><strong>Objetivo:</strong> aplicar la clasificación del parto a término del American College of Obstetricians and Gynaecologists (ACOG); describir la frecuencia de las diferentes categorías y hacer un análisis exploratorio de los resultados neonatales entre los grupos.</p><p><strong>Materiales y métodos:</strong> estudio de corte transversal. Se incluyeron gestantes consideradas inicialmente sanas, con embarazo a término definido según última menstruación confiable y ecografía en la primera mitad de la gestación, de una clínica privada de tercer nivel, de Cali (Colombia), año 2013. Los partos se clasificaron como parto a término temprano, a término y a término tardío. Se describen las características sociodemográficas maternas y los resultados perinatales, así como la frecuencia de cada categoría; la comparación de grupos se estableció a través de análisis de varianza (ANOVA), Kruskal-Wallis o chi cuadrado.</p><p><strong>Resultados:</strong> de 502 nacimientos, fueron clasificados como embarazos a término temprano 200 (39,8 %), completo 254 (50,6 %) y tardío 48 (9,6 %). Hubo mayor frecuencia de aseguramiento contributivo de la madre y embarazos de alto riesgo en el grupo a término temprano. Se observaron diferencias estadísticamente significativas en bajo peso al nacer y peso promedio del neonato en el grupo a término temprano, y mayor asfixia neonatal en el grupo a término tardío. No hubo diferencias en cuanto a síndrome de dificultad respiratoria y tiempo de hospitalización.</p><p><strong>Conclusión:</strong> la nueva clasificación de embarazo a término de la ACOG es factible de aplicar. La frecuencia de parto a término temprano es alta en Colombia. No se evidenciaron diferencias significativas en los resultados neonatales entre los tres grupos excepto en la asfixia neonatal, que fue mayor en el grupo a término tardío.</p>
FECOLSOG en la ruta para mejorar la salud materna, sexual y reproductiva
Authors: Díaz-Yamal Ivonne 
Published: December 2016

La Federación Colombiana de Obstetricia y Ginecología – FECOLSOG, encabezada por su junta directiva, ha iniciado el desarrollo de un plan estratégico proyectado para el 2020. Este nuevo plan responde a la situación de salud en nuestro país, y con base en ello decidimos orientar nuestras acciones en salud pública hacia la mejoría de los indicadores de salud materna y perinatal, desarrollar acciones en el campo de la salud sexual y reproductiva, el desarrollo de actividades de capacitación y recertificación de nuestros afiliados, y actualización de los procedimientos que deben ser cobijados por los planes de beneficios cubiertos con dineros públicos.
Study on Certain Blood and Serum Parameters of Camel Camelus dromedarius Maintained on Different Diets
Authors: Rakesh Poonia  , Aakash Srivastava  , Suchitra Sena  , Meera Srivastava  
Published: December 2016

Animals including camel (Camelus dromedaries), have been domesticated by man since ancient times especially in Rajasthan. Due to harsh climatic conditions there is often scarcity of grazing pastures in this area and therefore during summers camels are fed roughages and concentrates, as there remains no option to the local farmers. As a result, the proportion of the concentrate and roughage in the complete ration is expected to change the microbial population in the rumen, which in turn is expected to affect their capacity to colonize feed particles and may influence the nutrient utilization from the feed. Cluster bean (guar) belonging to family Leguminosae is one of the most suitable feed in arid areas. Besides, camels are also fed some millet flour or barley flour and gur (molasses) 1g/kg body weight. If this molasses is given in excess amount, it causes gastro-intestinal disorders. Due to introduction of new feed resources, this study was an attempt to investigate certain blood and serum parameters of camels maintained on different diets. An experimental trial was conducted in three groups of camels aged 3-4 years, each group comprising of 4 camels. Three experimental groups were framed Group 1 camels were fed guar phalgati (Cyamopsis tetragonaloba) and ground nut (Arachis hypogaea) chara in 1:1 ratio. Group 2 camels were provided ground nut chara alone while, to Group 3 camels jaggery 50% w/v was administrated orally at the dose 15 g/kg body weight apart from feeding of ground nut chara. The blood samples were collected for hematological, serum biochemical and enzymatic variations. Based on biochemical and enzymatic profile comparison, in the Group 3 camels a significant change in the digestive pattern leading towards acid indigestion was noted. There was an insignificant variation among the enzymatic and biochemical profile of Group 1 and Group 2. From the above blood and serum biochemical and enzymatic changes noticed in different groups fed with different diets, it can be envisaged that there exists a significant role of plan of nutrition on digestive pattern.