bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delineating the Peace: Marking Oaxaca's State Boundaries, 1856–1912
Authors: NEWCOMER DANIEL 
Published: April 2017

AbstractThis article analyses efforts by the state of Oaxaca to mark its border from 1856 to 1912. State officials hoped to demarcate a permanent border along the frontier as a way to delineate a peaceful ending to on-going boundary disputes, some of which allegedly dated to pre-Columbian times. The activity of marking Oaxaca's boundary effectively represented a literal process of Mexican state formation. Oaxaca officials attempted to negotiate the state's jurisdictional limits in cooperation with other federations as well as with their own citizens as they located the parameters of the state and the limits of its authority during the era.
Planning performance in schizophrenia patients: a meta-analysis of the influence of task difficulty and clinical and sociodemographic variables
Authors: Knapp F. , Viechtbauer W. , Leonhart R. , Nitschke K. , Kaller C. P. 
Published: April 2017

BackgroundDespite a large body of research on planning performance in adult schizophrenia patients, results of individual studies are equivocal, suggesting either no, moderate or severe planning deficits. This meta-analysis therefore aimed to quantify planning deficits in schizophrenia and to examine potential sources of the heterogeneity seen in the literature.MethodThe meta-analysis comprised outcomes of planning accuracy of 1377 schizophrenia patients and 1477 healthy controls from 31 different studies which assessed planning performance using tower tasks such as the Tower of London, the Tower of Hanoi and the Stockings of Cambridge. A meta-regression analysis was applied to assess the influence of potential moderator variables (i.e. sociodemographic and clinical variables as well as task difficulty).ResultsThe findings indeed demonstrated a planning deficit in schizophrenia patients (mean effect size:$\hat \mu \; = 0.67$; 95% confidence interval 0.56–0.78) that was moderated by task difficulty in terms of the minimum number of moves required for a solution. The results did not reveal any significant relationship between the extent of planning deficits and sociodemographic or clinical variables.ConclusionsThe current results provide first meta-analytic evidence for the commonly assumed impairments of planning performance in schizophrenia. Deficits are more likely to become manifest in problem items with higher demands on planning ahead, which may at least partly explain the heterogeneity of previous findings. As only a small fraction of studies reported coherent information on sample characteristics, future meta-analyses would benefit from more systematic reports on those variables.
Amphibian skin microbiota exhibits temporal variation in community structure but stability of predicted Bd-inhibitory function
Authors: Bletz Molly C , Perl R G Bina , Bobowski Bianca T C , Japke Laura M , Tebbe Christoph C , Dohrmann Anja B , Bhuju Sabin , Geffers Robert , Jarek Michael , Vences Miguel 
Published: April 2017

Abstract
Host-associated microbiomes are increasingly recognized to contribute to host disease resistance; the temporal dynamics of their community structure and function, however, are poorly understood. We investigated the cutaneous bacterial communities of three newt species, Ichthyosaura alpestris, Lissotriton vulgaris and Triturus cristatus, at approximately weekly intervals for 3 months using 16S ribosomal RNA amplicon sequencing. We hypothesized cutaneous microbiota would vary across time, and that such variation would be linked to changes in predicted fungal-inhibitory function. We observed significant temporal variation within the aquatic phase, and also between aquatic and terrestrial phase newts. By keeping T. cristatus in mesocosms, we demonstrated that structural changes occurred similarly across individuals, highlighting the non-stochastic nature of the bacterial community succession. Temporal changes were mainly associated with fluctuations in relative abundance rather than full turnover of bacterial operational taxonomic units (OTUs). Newt skin microbe fluctuations were not correlated with that of pond microbiota; however, a portion of community variation was explained by environmental temperature. Using a database of amphibian skin bacteria that inhibit the pathogen Batrachochytrium dendrobatidis (Bd), we found that the proportion of reads associated with ‘potentially’ Bd-inhibitory OTUs did not vary temporally for two of three newt species, suggesting that protective function may be maintained despite temporal variation in community structure.
Bacterial carbon use plasticity, phylogenetic diversity and the priming of soil organic matter
Authors: Morrissey Ember M , Mau Rebecca L , Schwartz Egbert , McHugh Theresa A , Dijkstra Paul , Koch Benjamin J , Marks Jane C , Hungate Bruce A 
Published: April 2017

Abstract
Microorganisms perform most decomposition on Earth, mediating carbon (C) loss from ecosystems, and thereby influencing climate. Yet, how variation in the identity and composition of microbial communities influences ecosystem C balance is far from clear. Using quantitative stable isotope probing of DNA, we show how individual bacterial taxa influence soil C cycling following the addition of labile C (glucose). Specifically, we show that increased decomposition of soil C in response to added glucose (positive priming) occurs as a phylogenetically diverse group of taxa, accounting for a large proportion of the bacterial community, shift toward additional soil C use for growth. Our findings suggest that many microbial taxa exhibit C use plasticity, as most taxa altered their use of glucose and soil organic matter depending upon environmental conditions. In contrast, bacteria that exhibit other responses to glucose (reduced growth or reliance on glucose for additional growth) clustered strongly by phylogeny. These results suggest that positive priming is likely the prototypical response of bacteria to sustained labile C addition, consistent with the widespread occurrence of the positive priming effect in nature.
Expression patterns of elemental cycling genes in the Amazon River Plume
Authors: Satinsky Brandon M , Smith Christa B , Sharma Shalabh , Landa Marine , Medeiros Patricia M , Coles Victoria J , Yager Patricia L , Crump Byron C , Moran Mary Ann 
Published: April 2017

Abstract
Metatranscriptomics and metagenomics data sets benchmarked with internal standards were used to characterize the expression patterns for biogeochemically relevant bacterial and archaeal genes mediating carbon, nitrogen, phosphorus and sulfur uptake and metabolism through the salinity gradient of the Amazon River Plume. The genes were identified in 48 metatranscriptomic and metagenomic data sets summing to &gt;500 million quality-controlled reads from six locations in the plume ecosystem. The ratio of transcripts per gene copy (a direct measure of expression made possible by internal standard additions) showed that the free-living bacteria and archaea exhibited only small changes in the expression levels of biogeochemically relevant genes through the salinity and nutrient zones of the plume. In contrast, the expression levels of genes in particle-associated cells varied over orders of magnitude among the stations, with the largest differences measured for genes mediating aspects of nitrogen cycling (nifH, amtB and amoA) and phosphorus acquisition (pstC, phoX and phoU). Taxa varied in their baseline gene expression levels and extent of regulation, and most of the spatial variation in the expression level could be attributed to changes in gene regulation after removing the effect of shifting taxonomic composition. We hypothesize that changes in microbial element cycling along the Amazon River Plume are largely driven by shifting activities of particle-associated cells, with most activities peaking in the mesohaline regions where N2 fixation rates are elevated.
Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
Authors: Kononenko Natalia L. , Claßen Gala A. , Kuijpers Marijn , Puchkov Dmytro , Maritzen Tanja , Tempes Aleksandra , Malik Anna R. , Skalecka Agnieszka , Bera Sujoy , Jaworski Jacek , Haucke Volker 
Published: April 2017

AbstractAutophagosomes primarily mediate turnover of cytoplasmic proteins or organelles to provide nutrients and eliminate damaged proteins. In neurons, autophagosomes form in distal axons and are trafficked retrogradely to fuse with lysosomes in the soma. Although defective neuronal autophagy is associated with neurodegeneration, the function of neuronal autophagosomes remains incompletely understood. We show that in neurons, autophagosomes promote neuronal complexity and prevent neurodegeneration in vivo via retrograde transport of brain-derived neurotrophic factor (BDNF)-activated TrkB receptors. p150Glued/dynactin-dependent transport of TrkB-containing autophagosomes requires their association with the endocytic adaptor AP-2, an essential protein complex previously thought to function exclusively in clathrin-mediated endocytosis. These data highlight a novel non-canonical function of AP-2 in retrograde transport of BDNF/TrkB-containing autophagosomes in neurons and reveal a causative link between autophagy and BDNF/TrkB signalling.
Prediction of intrinsic two-dimensional ferroelectrics in In2Se3 and other III2-VI3 van der Waals materials
Authors: Ding Wenjun , Zhu Jianbao , Wang Zhe , Gao Yanfei , Xiao Di , Gu Yi , Zhang Zhenyu , Zhu Wenguang 
Published: April 2017

AbstractInterest in two-dimensional (2D) van der Waals materials has grown rapidly across multiple scientific and engineering disciplines in recent years. However, ferroelectricity, the presence of a spontaneous electric polarization, which is important in many practical applications, has rarely been reported in such materials so far. Here we employ first-principles calculations to discover a branch of the 2D materials family, based on In2Se3 and other III2-VI3 van der Waals materials, that exhibits room-temperature ferroelectricity with reversible spontaneous electric polarization in both out-of-plane and in-plane orientations. The device potential of these 2D ferroelectric materials is further demonstrated using the examples of van der Waals heterostructures of In2Se3/graphene, exhibiting a tunable Schottky barrier, and In2Se3/WSe2, showing a significant band gap reduction in the combined system. These findings promise to substantially broaden the tunability of van der Waals heterostructures for a wide range of applications.
Simulation of the NMR response in the pseudogap regime of the cuprates
Authors: Chen Xi , LeBlanc J. P. F. , Gull Emanuel 
Published: April 2017

AbstractThe pseudogap in the cuprate high-temperature superconductors was discovered as a suppression of the Knight shift and spin relaxation time measured in nuclear magnetic resonance (NMR) experiments. However, theoretical understanding of this suppression in terms of the magnetic susceptiblility of correlated itinerant fermion systems was so far lacking. Here we study the temperature and doping evolution of these quantities on the two-dimensional Hubbard model using cluster dynamical mean field theory. We recover the suppression of the Knight shift and the linear-in-T spin echo decay that increases with doping. The relaxation rate shows a marked increase as T is lowered but no indication of a pseudogap on the Cu site, and a clear downturn on the O site, consistent with experimental results on single layer materials but different from double layer materials. The consistency of these results with experiment suggests that the pseudogap is well described by strong short-range correlation effects.
Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies
Authors: Hachiya Tsuyoshi , Furukawa Ryohei , Shiwa Yuh , Ohmomo Hideki , Ono Kanako , Katsuoka Fumiki , Nagasaki Masao , Yasuda Jun , Fuse Nobuo , Kinoshita Kengo , Yamamoto Masayuki , Tanno Kozo , Satoh Mamoru , Endo Ryujin , Sasaki Makoto , Sakata Kiyomi , Kobayashi Seiichiro , Ogasawara Kuniaki , Hitomi Jiro , Sobue Kenji , Shimizu Atsushi 
Published: April 2017

AbstractEpigenome-wide association studies, which searches for blood-based DNA methylation signatures associated with environmental exposures and/or disease susceptibilities, is a promising approach to a better understanding of the molecular aetiology of common diseases. To carry out large-scale epigenome-wide association studies while avoiding false negative detection, an efficient strategy to determine target CpG sites for microarray-based or sequencing-based DNA methylation profiling is essentially needed. Here, we propose and validate a hypothesis that a strategy focusing on CpG sites with high DNA methylation level variability may attain an improved efficacy. Through whole-genome bisulfite sequencing of purified blood cells collected from > 100 apparently healthy subjects, we identified ~2.0 million inter-individually variable CpG sites as potential targets. The efficacy of our strategy was estimated to be 3.7-fold higher than that of the most frequently used strategy. Our catalogue of inter-individually variable CpG sites will accelerate the discovery of clinically relevant DNA methylation biomarkers in future epigenome-wide association studies.
Latent virus reactivation in astronauts on the international space station
Authors: Mehta Satish K. , Laudenslager Mark L. , Stowe Raymond P. , Crucian Brian E. , Feiveson Alan H. , Sams Clarence F. , Pierson Duane L. 
Published: April 2017

AbstractReactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5 female) before, during, and after long-duration (up to 180 days) spaceflight onboard the international space station . Twenty age-matched and sex-matched healthy ground-based subjects were included as a control group. Blood, urine, and saliva samples were collected before, during, and after spaceflight. Saliva was analyzed for Epstein–Barr virus, varicella-zoster virus, and herpes simplex virus type 1. Urine was analyzed for cytomegalovirus. One astronaut did not shed any targeted virus in samples collected during the three mission phases. Shedding of Epstein–Barr virus, varicella-zoster virus, and cytomegalovirus was detected in 8 of the 23 astronauts. These viruses reactivated independently of each other. Reactivation of Epstein–Barr virus, varicella-zoster virus, and cytomegalovirus increased in frequency, duration, and amplitude (viral copy numbers) when compared to short duration (10 to 16 days) space shuttle missions. No evidence of reactivation of herpes simplex virus type 1, herpes simplex virus type 2, or human herpes virus 6 was found. The mean diurnal trajectory of salivary cortisol changed significantly during flight as compared to before flight (P = 0.010). There was no statistically significant difference in levels of plasma cortisol or dehydoepiandosterone concentrations among time points before, during, and after flight for these international space station crew members, although observed cortisol levels were lower at the mid and late-flight time points. The data confirm that astronauts undertaking long-duration spaceflight experience both increased latent viral reactivation and changes in diurnal trajectory of salivary cortisol concentrations.
Effectiveness and success factors of educational inhaler technique interventions in asthma & COPD patients: a systematic review
Authors: Klijn Sven L. , Hiligsmann Mickaël , Evers Silvia M. A. A. , Román-Rodríguez Miguel , van der Molen Thys , van Boven Job F. M. 
Published: April 2017

AbstractWith the current wealth of new inhalers available and insurance policy driven inhaler switching, the need for insights in optimal education on inhaler use is more evident than ever. We aimed to systematically review educational inhalation technique interventions, to assess their overall effectiveness, and identify main drivers of success. Medline, Embase and CINAHL databases were searched for randomised controlled trials on educational inhalation technique interventions. Inclusion eligibility, quality appraisal (Cochrane’s risk of bias tool) and data extraction were performed by two independent reviewers. Regression analyses were performed to identify characteristics contributing to inhaler technique improvement. Thirty-seven of the 39 interventions included (95%) indicated statistically significant improvement of inhaler technique. However, average follow-up time was relatively short (5 months), 28% lacked clinical relevant endpoints and all lacked cost-effectiveness estimates. Poor initial technique, number of inhalation procedure steps, setting (outpatient clinics performing best), and time elapsed since intervention (all, p < 0.05), were shown to have an impact on effectiveness of the intervention, explaining up to 91% of the effectiveness variation. Other factors, such as disease (asthma vs. chronic obstructive pulmonary disease), education group size (individual vs. group training) and inhaler type (dry powder inhalers vs. pressurised metered dose inhalers) did not play a significant role. Notably, there was a trend (p = 0.06) towards interventions in adults being more effective than those in children and the intervention effect seemed to wane over time. In conclusion, educational interventions to improve inhaler technique are effective on the short-term. Periodical intervention reinforcement and longer follow-up studies, including clinical relevant endpoints and cost-effectiveness, are recommended.
Demonstration of quantum advantage in machine learning
Authors: Ristè Diego , da Silva Marcus P. , Ryan Colm A. , Cross Andrew W. , Córcoles Antonio D. , Smolin John A. , Gambetta Jay M. , Chow Jerry M. , Johnson Blake R. 
Published: April 2017

AbstractThe main promise of quantum computing is to efficiently solve certain problems that are prohibitively expensive for a classical computer. Most problems with a proven quantum advantage involve the repeated use of a black box, or oracle, whose structure encodes the solution. One measure of the algorithmic performance is the query complexity, i.e., the scaling of the number of oracle calls needed to find the solution with a given probability. Few-qubit demonstrations of quantum algorithms, such as Deutsch–Jozsa and Grover, have been implemented across diverse physical systems such as nuclear magnetic resonance, trapped ions, optical systems, and superconducting circuits. However, at the small scale, these problems can already be solved classically with a few oracle queries, limiting the obtained advantage. Here we solve an oracle-based problem, known as learning parity with noise, on a five-qubit superconducting processor. Executing classical and quantum algorithms using the same oracle, we observe a large gap in query count in favor of quantum processing. We find that this gap grows by orders of magnitude as a function of the error rates and the problem size. This result demonstrates that, while complex fault-tolerant architectures will be required for universal quantum computing, a significant quantum advantage already emerges in existing noisy systems.
Thought disorder measured as random speech structure classifies negative symptoms and schizophrenia diagnosis 6 months in advance
Authors: Mota Natália B. , Copelli Mauro , Ribeiro Sidarta 
Published: April 2017

AbstractIn chronic psychotic patients, word graph analysis shows potential as complementary psychiatric assessment. This analysis relies mostly on connectedness, a structural feature of speech that is anti-correlated with negative symptoms. Here we aimed to verify whether speech disorganization during the first clinical contact, as measured by graph connectedness, can correctly classify negative symptoms and the schizophrenia diagnosis 6 months in advance. Positive and negative syndrome scale scores and memory reports were collected from 21 patients undergoing first clinical contact for recent-onset psychosis, followed for 6 months to establish diagnosis, and compared to 21 well-matched healthy subjects. Each report was represented as a word-trajectory graph. Connectedness was measured by number of edges, number of nodes in the largest connected component and number of nodes in the largest strongly connected component. Similarities to random graphs were estimated. All connectedness attributes were combined into a single Disorganization Index weighted by the correlation with the positive and negative syndrome scale negative subscale, and used for classifications. Random-like connectedness was more prevalent among schizophrenia patients (64 × 5% in Control group, p = 0.0002). Connectedness from two kinds of memory reports (dream and negative image) explained 88% of negative symptoms variance (p < 0.0001). The Disorganization Index classified low vs. high severity of negative symptoms with 100% accuracy (area under the receiver operating characteristic curve = 1), and schizophrenia diagnosis with 91.67% accuracy (area under the receiver operating characteristic curve = 0.85). The index was validated in an independent cohort of chronic psychotic patients and controls (N = 60) (85% accuracy). Thus, speech disorganization during the first clinical contact correlates tightly with negative symptoms, and is quite discriminative of the schizophrenia diagnosis.
Alice-Bob Physics: Coherent Solutions of Nonlocal KdV Systems
Authors: Lou S. Y. , Huang Fei 
Published: April 2017

AbstractIn natural and social science, many events happened at different space-times may be closely correlated. Two events, A (Alice) and B (Bob) are defined correlated if one event is determined by another, say, $${\boldsymbol{B}}=\hat{{\boldsymbol{f}}}A$$
B
=

f
ˆ

A
for suitable $$\hat{{\boldsymbol{f}}}$$

f
ˆ

operators. Taking KdV and coupled KdV systems as examples, we can find some types of models (AB-KdV systems) to exhibit the existence on the correlated solutions linked with two events. The idea of this report is valid not only for physical problems related to KdV systems but also for problems described by arbitrary continuous or discrete models. The parity and time reversal symmetries are extended to shifted parity and delayed time reversal. The new symmetries are found to be useful not only to establish AB-systems but also to find group invariant solutions of numerous AB-systems. A new elegant form of the N-soliton solutions of the KdV equation and then the AB-KdV systems is obtained. A concrete AB-KdV system derived from the nonlinear inviscid dissipative and barotropic vorticity equation in a β-plane channel is applied to the two correlated monople blocking events which is responsible for the snow disaster in the winter of 2007/2008 happened in Southern China.
Pestalotiopsis and allied genera from Camellia, with description of 11 new species from China
Authors: Liu Fang , Hou Lingwei , Raza Mubashar , Cai Lei 
Published: April 2017

AbstractA total of 124 Pestalotiopsis-like isolates associated with symptomatic and asymptomatic tissues of Camellia sinensis and other Camellia spp. from eight provinces in China were investigated. Based on single- and multi-locus (ITS, TEF, TUB2) phylogenies, as well as morphological characters, host associations and geographical distributions, they were classified into at least 19 species in three genera, i.e. Neopestalotiopsis, Pestalotiopsis and Pseudopestalotiopsis. Eight novel species in Pestalotiopsis and three novel species in Pseudopestalotiopsis were described. Our data suggested that the currently widely used loci in Pestalotiopsis-like genera do not consistently provide stable and sufficient resolution tree topologies, especially for Neopestalotiopsis. Moreover, the number, branch pattern and length of the conidial basal appendages were revealed to be phylogenetically informative characters in Pestalotiopsis.