bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract A33: Discovery of novel anti-cancer therapeutic agents for Notch activation complex kinase (NACK) targeting the Notch pathway
Authors: Zhu Xiaoxia , Wang Zhiqiang , Jin Ke , Astudillo Luisana , Zhou Wen , Chen Jinshui , Buchwald Peter , Schürer Stephan C. , Capobianco Anthony J. 
Published: January 2017

Abstract
The Notch signaling pathway has been found to play an important role in multiple human cancers by regulating transcriptional programs. However, the mechanism by which Notch drives target gene transcription is still elusive. In our previous study, we have identified and characterized a novel Notch activation complex kinase, NACK, which acts as a Notch transcriptional co-activator and an essential regulator of Notch-mediated tumorigenesis and development. In this regard, NACK could become a putative drug target in anti-cancer therapies.
The lack of three-dimensional (3D) structure of NACK hinders the designing of potential drug inhibitors. Therefore, computational methods are adopted to elucidate the structural and functional features of NACK, which further aid in designing new NACK inhibitors. Molecule docking (Glide) is utilized to obtain potential hit inhibitors for NACK, which will be validated using in-vitro and in-vivo assays. This will open avenues for the development of new therapies for Notch-dependent cancers.
Citation Format: Xiaoxia Zhu, Zhiqiang Wang, Ke Jin, Luisana Astudillo, Wen Zhou, Jinshui Chen, Peter Buchwald, Stephan C. Schürer, Anthony J. Capobianco. Discovery of novel anti-cancer therapeutic agents for Notch activation complex kinase (NACK) targeting the Notch pathway. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr A33.
Abstract A35: Olaparib causes premature loss of cohesion in cancer cells
Authors: Kukolj Eva , Kaufmann Tanja , Dick Amalie E. , Zeillinger Robert , Gerlich Daniel W. , Slade Dea 
Published: January 2017

Abstract
Although it has been decades since PARP inhibitors were initially discovered and various clinical trials have been performed, their mode of action in killing tumor cells subsequent to PARP inhibition is still not fully understood. We have recently identified poly(ADP-ribosyl)ation (PARylation) as a new post-translational modification of the cohesin complex, a key player in chromosome segregation during mitosis. We investigated the effect of PARP inhibition on mitosis in a panel of cells of cancer (cervical, breast, ovarian) and normal tissue origin. We treated cancerous and non-cancerous cell lines labelled with chromatin markers with a selected set of PARP inhibitors and imaged them with fluorescence live microscopy.
Out of 5 tested inhibitors, a well-known and clinically relevant PARP inhibitor olaparib, induced strongest perturbations in mitotic progression. Olaparib induced a delay in entering anaphase, problems aligning chromosomes at the metaphase plate and premature loss of cohesion (cohesion fatigue) after a prolonged metaphase arrest. Cohesion fatigue, leading to cell death, was observed in cancer cell lines exhibiting S-phase stalling or G2/M arrest with increased protein levels of PARP1. Olaparib is known to entrap PARP1 at replication forks and thereby perturb replication fork movement. While its addition before the onset of mitosis did not result in mitotic defects, addition of olaparib only in S-phase was sufficient to cause mitotic phenotypes. Our results indicate that PARP inhibition by olaparib in S phase has downstream effects on mitotic progression. PARP1 RNAi in addition to olaparib treatment rescues the cohesion fatigue phenotype, suggesting that entrapment of PARP1 at the replication fork upon its inhibition is the main cause of cohesion fatigue. Cohesion fatigue was observed only in highly aneuploid cancer cells that are described to have an increased rate of chromosome mis-segregation.
In conclusion, higher susceptibility of aneuploid cancer to cohesion fatigue and cell death upon olaparib treatment relative to normal cells would support its use as anti-mitotic chemotherapy.
Citation Format: Eva Kukolj, Tanja Kaufmann, Amalie E. Dick, Robert Zeillinger, Daniel W. Gerlich, Dea Slade. Olaparib causes premature loss of cohesion in cancer cells. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr A35.
Abstract A44: A landscape of pharmacogenomic interactions in cancer
Authors: Iorio Francesco , Knijnenburg Theo , vis Daniel , Bignell Graham , Menden Michael , Wessels Lodewyk , Saez-Rodriguez Julio , McDermott Ultan , Garnett Mathew 
Published: January 2017

Abstract
Systematic studies of cancer genomes are providing unprecedented insights into the molecular nature of human cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here we report how cancer-driving alterations identified in 11,289 tumors from 29 tissues (integrating mutations, copy-number alterations, methylation and gene expression) correlate with response to 265 compounds profiled in 1,001 human cancer cell-lines. We find that cell-lines faithfully recapitulate oncogenic aberrations identified in tumors, and that many of these associate with drug sensitivity or resistance. Logic-based modeling uncovers combinations of aberrations that specifically sensitize to drugs, while machine-learning demonstrates the redundancy of different molecular data types in predicting drug response. Our comprehensive analysis and associated datasets are rich resources to identify novel therapeutic options for selected cancer sub-populations.
Citation Format: Francesco Iorio, Theo Knijnenburg, Daniel vis, Graham Bignell, Michael Menden, Lodewyk Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew Garnett. A landscape of pharmacogenomic interactions in cancer. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr A44.
Abstract B21: Brd4 modulates S-phase checkpoint response and sensitizes ovarian cancer cells to ATR inhibition
Authors: Zhang Jingwen , Chen Huawei , Dulak Austin 
Published: January 2017

Abstract
The BET (bromodomain and extra terminal domain) family proteins function as chromatin readers through interactions with acetylated lysine residues on both histones and transcription factors. BRD4 is the most well-studied member of this group that promotes tumorigenesis by regulating expression of core transcriptional programs; however, the role of Brd4 in other cellular processes is not entirely clear. Here, we show using small molecule inhibition of the BET proteins that Brd4 is required to maintain S-phase checkpoint signaling. Treatment of high-grade serous ovarian and osteosarcoma cancer cell lines with BET inhibitors, AZD5153 and JQ1, results in the accumulation of gH2AX and 53BP1 foci formation, which is suggestive of elevated DNA damage levels. The induction of DNA damage caused by both inhibitors corresponds with cell cycle arrest at the G1/S boundary. Displacement of Brd4 in cell lines under intrinsic or exogenous replication stress led to a time-dependent reduction in phospho-Chk1 first detected within 30 minutes of AZD5153 treatment in U2OS cells. The decrease in Chk1 phosphorylation was observed without a concomitant decrease in total Chk1, and this was not replicated by treatment with pan-transcriptional inhibitors, suggesting a non-transcriptional mechanism linked to Brd4. Furthermore, Brd4 interacts with core DNA replication machinery during S-phase and inhibition of Brd4 leads to aberrant DNA replication without decreasing ATR phosphorylation. Consistent with a role in S-phase signaling, Brd4 inhibition sensitizes replicating cells to replication stress-inducing agents. Finally, we observed that ovarian cancer cell lines are highly-sensitive to the combination of Brd4 and ATR (AZD6738) inhibitors. Concurrent treatment with AZD5153 and AZD6738 induces DNA damage and apoptosis in a synergistic manner. Together, these findings highlight a novel function for Brd4 and provide evidence to support further evaluation of Brd4i combinations with DNA damage repair agents.
Citation Format: Jingwen Zhang, Huawei Chen, Austin Dulak. Brd4 modulates S-phase checkpoint response and sensitizes ovarian cancer cells to ATR inhibition. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr B21.
Abstract B28: Induced expression of Sprouty4 in breast invasive ductal carcinoma cells inhibits ERK MAP kinase and reduces malignant phenotype
Authors: Jackson Ryan M. , Brock Ethan J. , Shah Seema , Sameni Mansoureh , Sloane Bonnie F. , Li Quanwen , Mattingly Raymond R. 
Published: January 2017

Abstract
Our previous work has identified increased expression of Sprouty4 in 3D models of breast ductal carcinoma in situ (DCIS). Sprouty4 in other systems has been shown to function as a negative regulator of the mitogen activated protein kinase (MAPK/ERK) pathway. We hypothesize that Sprouty4 is an endogenous inhibitor of ERK/MAPK signaling in DCIS, and that its loss or reduced expression is one mechanism by which triple-negative lesions progress toward invasive ductal carcinoma (IDC). Using immunohistochemistry our labs have found that Sprouty4 was highly expressed in some human premalignant breast tissue samples, and that this expression was reduced in malignant triple-negative samples. These results correspond with immunoblot data from our 3D culture model of breast cancer progression in which Sprouty4 expression was higher during DCIS than in the IDC stage. Efficient over-expression of Sprouty4 reduced both MAPK/ERK activity as well as the aggressive phenotype of MCF10.CA1d IDC cells. Immunofluorescence experiments done in IDC cells overexpressing Sprouty4 revealed relocation of E-cadherin back to the cell surface and the restoration of adherens junctions. To determine if these effects were due to changes in MAPK/ERK signaling, IDC cells were treated with MEK162, an allosteric MEK inhibitor. Nanomolar concentrations of drug restored an epithelial-like phenotype similar to that produced by Sprouty4 over-expression. From these data we conclude that Sprouty4 may act to control MAPK/ERK signaling in a subset of DCIS, thus limiting the progression of these premalignant breast cancers. Further, if in vivo data correspond with our in vitro work, this may argue for the investigation of MEK inhibitors as an adjunct treatment in triple-negative disease, where options are limited.
Citation Format: Ryan M. Jackson, Ethan J. Brock, Seema Shah, Mansoureh Sameni, Bonnie F. Sloane, Quanwen Li, Raymond R. Mattingly. Induced expression of Sprouty4 in breast invasive ductal carcinoma cells inhibits ERK MAP kinase and reduces malignant phenotype. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr B28.
Adherence to a Healthy Nordic Diet and Risk of Stroke
Authors: Hansen Camilla Plambeck , Overvad Kim , Kyrø Cecilie , Olsen Anja , Tjønneland Anne , Johnsen Søren Paaske , Jakobsen Marianne Uhre , Dahm Christina Catherine 
Published: January 2017

Background and Purpose—
Specific dietary patterns, including the Mediterranean diet, have been associated with stroke prevention. Our aim was to investigate whether adherence to a healthy Nordic diet, including fish, apples and pears, cabbages, root vegetables, rye bread, and oatmeal, was associated with risk of stroke.

Methods—
Incident cases of stroke among 55 338 men and women from the Danish Diet, Cancer and Health cohort were identified from the Danish National Patient Register and verified by review of records. Cases of ischemic stroke were further subclassified based on etiology according to the TOAST classification system (Trial of Org 10172 in Acute Stroke Treatment). Information on diet was collected at baseline (1993–1997) using a semiquantitative food-frequency questionnaire. Cox proportional hazards models were used to estimate hazards ratios of total stroke and subtypes of ischemic and hemorrhagic stroke.

Results—
During a median follow-up of 13.5 years, 2283 cases of incident stroke were verified, including 1879 ischemic strokes. Adherence to a healthy Nordic diet, as reflected by a higher Healthy Nordic Food Index score, was associated with a lower risk of stroke. The hazards ratio comparing an index score of 4 to 6 (high adherence) with an index score of 0 to 1 (low adherence) was 0.86 (95% confidence interval 0.76–0.98) for total stroke. Inverse associations were observed for ischemic stroke, including large-artery atherosclerosis. No trend was observed for hemorrhagic stroke; however, a statistically insignificant trend was observed for intracerebral hemorrhage.

Conclusions—
Our findings suggest that a healthy Nordic diet may be recommended for the prevention of stroke.
The Negotiability of Debt in Islamic Finance: An Analytical and Critical Study
Authors: Almezeini Abdulaziz A. 
Published: January 2017

The challenges posed by the non-liquidity and non-diversity of the Islamic debts market make the market an inefficient tool on contributing to Muslim economic growth. Islamic scholars and experts created sukuk as an Islamic debt instrument to avoid riba (usury), but the sukuk market (especially in the Gulf) still struggles with the prohibition of the trade of debt due to the prohibition of the two Fiqh Academies.Trading and securitizing debts should be permitted in Islamic law, with one condition, that the debt should be considered low risk. This new rule, the permissibility of trading debts, is supported by three Islamic legal bases, istishab, qiyas, and maslaha, which are recognized by all four Islamic schools of legal thought. Furthermore, permitting the trading of debts is more consistent with the principles and theories of Islamic law than is forbidding it. It is consistent with the obligations theory that debt is a personal right. It is consistent with the mal (property) theory that debt may be sold according to the three Islamic schools of legal thought, all of which consider debt as property. It is consistent with other modern Islamic financial transactions that are permitted by the two Fiqh Academies, such as tawarruq and murabaha.
Rozliczenie z Brasławszczyzną
Authors: Smułkowa Elżbieta 
Published: January 2017

Material from the Braslav in BelarusThis article has two aims: 1. To thank the reviewers of the two-volume publication Brasławszczyzna, memory and the present for their careful study of the texts and glossaries included in it, for eliciting and emphasizing methodological, theoretical and material merits, and revealing some of its shortcomings. 2. To open the opportunity for me, as the author and the editor of the project, to engage in polemics with some of the outlooks of the reviewers and to show, from time perspective, what could have been done better. Rozliczenie z BrasławszczyznąArtykuł ma do spełnienia dwa cele. 1. Ma podziękować Recenzentom dwutomowej publi­kacji Brasławszczyzna pamięć i współczesność za uważne zapoznanie się z zawartymi w niej tekstami i słownikiem, za wydobycie i podkreślenie zalet metodologicznych, teoretycznych i materiałowych pracy oraz ukazanie pewnych jej braków. 2. Stwarza mi możliwość, jako współautorce i redaktorce projektu, przeprowadzenia polemiki z niektórymi poglądami Recenzentów oraz ukazania z perspektywy czasowej, co można było zrobić lepiej.
Wpływ języka polskiego na leksykę medyczną w gwarze staroobrzędowców regionu suwalsko-augustowskiego
Authors: Grupa Magdalena Katarzyna 
Published: January 2017

The Influence of Polish Language on Medical Terminology in the Old Believers’ Dialect in Suwałki-Augustów Region The Old Believers in Poland are a bilingual community. They use two languages: Russian dialect and Polish language. Polish influence on the Old Believers’ dialect increased after two World Wars, when they became separated from their co-religionists in other countries and had more often contacts with Polish neighbours. Their language situation may be characterized as diglossia – they choose one of their languages depending on the domain of life and other social conditions.The medical terminology is a specific part of the Old Believers’ dialect. There are a lot of borrowings from Polish language caused by the need of protection of health and life in Poland, where the Old Believers met first of all with Polish health care system. The article is an attempt to characterize the influence of Polish language in the lexis describing medicine and health care. Wpływ języka polskiego na leksykę medyczną w gwarze staroobrzędowców regionu suwalsko-augustowskiego Staroobrzędowcy w Polsce są społecznością dwujęzyczną. Posługują się rosyjską gwarą oraz językiem polskim. Częstsze kontakty z Polakami po I i II wojnie światowej oraz izolacja od współwyznawców w innych krajach poskutkowały modyfikacjami języka. Ich sytuację językową określa się jako dyglosję – zjawisko polegające na używaniu dwu (lub więcej) języków naprzemiennie, zależnie od sytuacji komunikacyjnej.Terminologia medyczna jest specyficzną częścią systemu leksykalnego polskich starowierców. Cechuje ją znaczna liczba zapożyczeń z polszczyzny w stosunku do leksyki rosyjskiego języka ogólnego i rodzimej gwary rosyjskiej. Znajduje to uzasadnienie w konieczności przyswojenia sobie terminów związanych z lecznictwem w ich polskim brzmieniu, dzięki czemu możliwe jest korzystanie z opieki zdrowotnej w Polsce. W artykule został opisany wpływ polszczyzny na leksykę z zakresu medycyny i ochrony zdrowia.
Два своеобразных словаря латышского языка
Authors: Бушс [Bušs] Оярс [Ojārs] 
Published: January 2017

Latviešu-igauņu vārdnīca. Projektijuht [Manager of the project] Arvi Tavast. Tallinn: Eesti Keele Sihtasutus, 2015, 737 pp.Igauņu-latviešu vārdnīca. Atb. red. [Ed.] Valts Ernštreits. Rīga: Latviešu valodas aģentūra, Tallinn: Eesti Keele Sihtasutus, 2015, 1096 pp. ReviewTwo Peculiar Dictionaries of LatvianEstonian-Latvian dictionary (ed. Valts Ernštreits) and Latvian-Estonian dictionary (manager of the project Arvi Tavast) have been published at the same time and with the same design. Each of the dictionaries consists from more than forty thousand headwords, however they are not of the same size, Estonian-Latvian dictionary has significantly more pages. The reason is the Estonian-Latvian dictionary is a traditional bilingual dictionary, were we can find among other information a lot of illustrations for the use of translated lexis. Latvian-Estonian dictionary could be probably called an experimental dictionary. It is compiled on the basis of the parallel corpus, the lexical materials have been mostly processed automatically using specialized software, pro­fessional lexicographers did not participated in the compiling of this dictionary. As a result this Latvian-Estonian dictionary seems more like a glossary, we do not have examples of the use of translated words in this dictionary. What is very strange is that quite a lot of headwords are not words, they are groups of words. This experimental dictionary demonstrates that software alone still is not able to compile a dictionary of high quality without the help of experienced lexicographers. RecenzjaDwa osobliwe słowniki języka łotewskiegoSłowniki estońsko-łotewski (red. Valts Ernštreits) i łotewsko-estoński (kierownik projektu Arvi Tavast) zostały opublikowane jednocześnie i w takiej samej szacie graficznej. W każdym z nich zawarto ponad 40 tysięcy haseł, jednakże słowniki te nie mają identycznej objętości, gdyż słownik estońsko-łotewski liczy znacznie więcej stron. Wynika to z tego, że jest on tradycyjnym słownikiem dwujęzycznym, w którym poza innymi informacjami możemy znaleźć mnóstwo przykładów użycia tłumaczonej leksyki. Z kolei słownik łotewsko-estoński mógłby zapewne zostać nazwany eksperymentalnym. Został on opracowany na podstawie paralelnego korpusu, materiał leksykalny na ogół opracowano automatycznie przy zastosowaniu specjalistycznego oprogramowania, a profesjonalni leksykografowie nie uczestniczyli w autorskiej pracy nad tym słownikiem. W efekcie bardziej przypomina on zestawienie słownictwa, nie ma bowiem w tym słowniku przykładów użycia tłumaczonych wyrazów. Dziwne jest to, że wiele z haseł wyrazowych to w ogóle nie są wyrazy, lecz grupy wyrazów. Ten eksperymentalny słownik dowodzi, że samo oprogramowanie wciąż nie wystarcza, aby opracować dobrej jakości słownik bez udziału doświadczonych leksykografów.
Janusz Rieger, Słownictwo polszczyzny gwarowej na Brasławszczyźnie, Warszawa: Wydawnictwo Naukowe Sub Lupa, 2014, 459 ss.
Authors: Głuszkowski Michał 
Published: January 2017

ReviewReview on Janusz Rieger’s Słownictwo polszczyzny gwarowej na Brasławszczyźnie, Warszawa: Wydawnictwo Naukowe Sub Lupa, 2014, 459 ss. The given work characterizes Polish dialectal lexis including foreign influence in the Brasław region. In the review Rieger’s work was compared with other publications on the given topic, as well as the content was analyzed. RecenzjaRecenzja opracowania Janusza Riegera, Słownictwo polszczyzny gwarowej na Bra­sławszczyźnie, Warszawa: Wydawnictwo Naukowe Sub Lupa, 2014, 459 ss. Praca przedstawia polską leksykę gwarową w regionie brasławskim wraz z obcymi wpływami. W recenzji dokonano porównania z innymi pracami na temat słownictwa danego obszaru i dokonano omówienia treści.
Śladami historii Bałtów i Słowian: spojrzenie na melodie białoruskich pieśni żniwnych
Authors: Žičkienė Aušra 
Published: January 2017

Галина Кутырёва-Чубаля, Белорусский жнивный напев: архетипы, инновации, диалекты, Bielsko-Biała: Wydawnictwo Akademii Techniczno-Humanistycznej, 2009, 264 ss. ReviewTracing the Footsteps of the Baltic and Slavic History: Lancing at the Melodies of the Belorussian Harvest Songs The book review: Кутырева-Чубаля, Г. (2009). Белорусский жнивный напев: архетипы, инновации, диалекты. Bielsko-Biała: Wydawnictwo Akademii Techniczno-Humanistycznej. The rewiev contains the critical, polemical analysis of the objective content of the book. In the rewiever‘s conclusion, the investigation made by author seems to be on the level of the scientific discovery, however, the book did not reach more readers probably because of some vexatious pecularities of its form and unfavourable circumstances. RecenzjaŚladami historii Bałtów i Słowian: spojrzenie na melodie białoruskich pieśni żniwnych Recenzja książki Galiny Kutyriowej-Czubali Белорусский жнивный напев: архетипы, инновации, диалекты. Bielsko-Biała: Wydawnictwo Akademii Techniczno-Humani­stycznej, 2009. Recenzja stanowi krytyczno-polemiczną analizę części merytorycznej książki. Autorka recenzji przekonuje, że pracę tę można uznać za prawdziwe odkrycie naukowe, jednak z powodu przyjętych w niej rozwiązań formalnych oraz niesprzy­jających okoliczności nie trafiła ona do szerszego grona odbiorców.