bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beta-Blocker in Heart Rate Control and Cardio Protection: The Role of ADRB1 Variants and HCN4 Regulation – A Systematic Review
Authors: Niruri Rasmaya , Ikawati Zullies , Nugroho Agung Endro , Arifianto Habibie 
Published: September 2024

Elevated heart rate is linked to adverse cardiovascular outcomes. Sinoatrial (SA) nodes, hyperpolarization-activated cyclic nucleotide-gated-4 (HCN4) channels, and beta1-adrenergic receptor (ADRB1) are responsible for generating the heart rate. Beta-blockers have a cardioprotective effect on heart failure, including controlling heart rate. However, the responses to beta-blockers can vary among individuals. ADRB1 genetic variability may be contributed to the differential beta-blocker effect in heart failure. HCN4 also performs a crucial function in the pacemaker cells of the heart. Exploring the effect of beta-blockers in pacemaker cells is expanding the view of their role and their therapeutic response in heart failure. The objectives of this study were to identify ADRB1 genetic variants affecting heart rate response in heart failure subjects with beta-blocker treatment and to explore the effect of beta-blockers on HCN4 channels and SA nodes. A systematic review was performed using three databases. Eight of 668 manuscripts were selected. The systematic review found that ADRB1 genetic variants (A145G (Ser49Gly) and C1165G (Arg389Gly)) can affect heart rate response in beta-blocker-treated heart failure. The study also found that the percentage of patients with the Ser49Ser-Gly389X haplotype achieved a heart rate target was higher than other haplotypes. Individuals with the Arg389Arg genotype necessitated a markedly increased amount of beta-blocker dose to reach the identical heart rate target compared to those with the Gly389X gene variation. In addition, the review found that carvedilol, a beta-blocker derivative, demonstrated beneficial effects in inhibiting HCN-gated channels. Bisoprolol and carvedilol improved channel regulation in the SA Node by reversing the downregulation of HCN4 and sodium channels. In general, this systematic review provides important insights into beta-blockers in treating heart failure, specifically concerning the genetic variability of ADRB1 and the beta-blockers effect on the SA node and HCN4 channels.
Impact of controlled physical training on clinicopathological and psychophysiological features of patients with chronic heart failure and type 2 diabetes
Authors: Sinkova M. N. , Isakov L. K. , Plotnikova E. Yu. , Barbarash O. L. 
Published: September 2024

Aim. To evaluate the effectiveness of long-term (five-year) supervised physical exercise in patients with chronic heart failure (CHF) following myocardial infarction (MI) and type 2 diabetes mellitus (T2DM).Materials and Methods. The study included 88 patients with CHF of functional class II-III after MI and concomitant T2DM. In addition to standard medication therapy, patients in the main group (n = 42) performed regular moderate-intensity physical exercises for 30−60 minutes at least 5 days a week. The control group consisted of 46 patients who received standard medication therapy. Patients in both groups had similar clinical and demographic characteristics. After 5 years of follow-up, we assessed the incidence of a composite endpoint (death, MI, emergency myocardial revascularization, acute CHF decompensation), quality of life (measured by the SF36 questionnaire), levels of anxiety and depression (measured by the HADS questionnaire), and levels of fatigue (measured by the MFI-20 questionnaire). By the end of the five-year observation period, data were available for 40 patients in the main group (11 patients were excluded from the study due to discontinuation of regular physical exercise) and 42 patients in the control group.Results. The incidence of the composite endpoint was 55.2% and 80.9% in main and control group, respectively (p = 0.038). Regular physical exercise over the five-year period was associated with a higher quality of life according to the SF36 questionnaire (64.5 [63.1; 67.8] vs. 49.2 [48.4; 49.8], p = 0.001), lower levels of anxiety (5.8 [5.1; 7.7] vs. 8.0 [6.8; 9.2], p = 0.042) and depression (2.9 [2.2; 4.2] vs. 10.7 [10.5; 12.3], p = 0.001) according to the HADS questionnaire, and lower levels of general fatigue according to the MFI-20 questionnaire (9.1 [8.5; 11.2] vs. 15.1 [14.5; 15.4], p = 0.019).Conclusion. Long-term regular physical exercise in patients with CHF and T2DM improves cardiovascular outcomes and psychological status of patients.
Maternal and newborn outcomes in patients with endometriosis-associated infertility
Authors: Tishchenko E. N. , Artymuk N. V. , Zotova O. A. , Danilova L. N. 
Published: September 2024

Aim. To identify the characteristics of pregnancy and childbirth in women with endometriosis-associated infertility (EAI).Materials and Methods. Here we performed retrospective case-control study which included 115 women with histologically verified endometriosis and 250 women without this condition. Statistical analysis was conducted using the IMB SPSS Statistics 20 software package. The data distribution was assessed using the Kolmogorov-Smirnov test. Quantitative data are presented as median (Me) and interquartile range (Q1 – Q3) using the Mann-Whitney test. The level of statistical significance for testing the null hypothesis was set at p < 0.05.Results. Pregnancy in patients with EAI was statistically significantly more often complicated by placenta previa compared to the control group: 6 (5.2%) versus 3 (1.2%) (p = 0.031). Patients with EAI were delivered via cesarean section in 49.6% of cases, compared to 13.2% in those without EAI (p < 0.001). Labor in women with EAI was statistically significantly more often complicated by uterine inertia (hypotonic labor, 7.0% versus 2.4% in those without EAI, p = 0.043), retained placenta (4.3% vs 0.4%, p = 0.013); and hypotonic bleeding (3.5% vs 0.4%, p = 0.036). Maternal and neonatal outcomes including birth weight, Apgar scores at 1 and 5 minutes, and the duration of hospital stay did not differ significantly between the groups.Conclusions. Patients with EAI are characterized by a complicated course of pregnancy and childbirth with a higher incidence of placenta previa, abnormal labor, hypotonic bleeding, retained placenta, and cesarean delivery. Hence, the development of respective therapeutic and preventive measures is required to prevent these complications.
Risk of central nervous system tumors in the offspring of individuals exposed to production radiation
Authors: Sosnina S. F. , Okatenko P. V. , Denisova E. V. , Sokolnikov M. E. 
Published: September 2024

Aim. To assess the risk of malignant central nervous system (CNS) tumors among the first-generation offspring of workers from the Mayak Production Association.Materials and Methods. A retrospective epidemiological analysis was conducted in a cohort of the offspring of workers from Russia's first nuclear power plant (n = 8890), born between 1949 and 1973. The comparison group consisted of 4345 offspring born during the same period to non-exposed parents. The observation period covered 72 years (1949−2020), with a total of 818,208 person-years of follow-up. The analysis focused on the frequency, dynamics, and structure of CNS malignancies. The relative risk of CNS tumors and the excess relative risk per unit dose of parental occupational radiation exposure were calculated with 95% confidence intervals.Results. Overall, the frequency of CNS tumors in both groups over the entire observation period did not differ significantly (3.4 per 1000 in the main group, 1.8 per 1000 in the comparison group). Analysis of CNS tumor incidence dynamics across calendar periods showed no significant differences, with the peak in the main group occurring during 2001−2010. No significant differences were found in the age of CNS tumor onset or the average age of parents at the time of offspring birth. Histological structure and localization of CNS tumors varied across groups. The relative risk assessment for CNS tumors showed a statistically insignificant increase in risk among the offspring in the main group when considering total observations and sex-specific analyses. Among the offspring of mothers with confirmed preconceptional and intrauterine occupational radiation exposure, the relative risk of CNS tumors was higher for males and both sexes combined (3.6 [1.06−12.28] and 2.74 [1.08−6.93]; 4.34 [1.27−14.77] and 3.3 [1.31−8.36], respectively). However, the analysis of excess relative risk did not indicate significant risk estimates for maternal radiation exposure, neither in general nor across different dose intervals.Conclusion. The study did not confirm the hypothesis that parental occupational radiation exposure influences the risk of CNS tumors in offspring. Given the relatively young age of the cohort and the low number of CNS tumor cases, issues related to maternal radiation exposure require further observation.
Leveraging BIM Technology for Comprehensive Lifecycle Management in Engineering Projects
Authors: Lu Ziyu 
Published: September 2024

Abstract
This research explores the impact of Building Information Modeling (BIM) on engineering project lifecycle management. A mixed-methods approach, combining quantitative data from surveys and case studies with qualitative insights from interviews, reveals that BIM significantly reduces cost and time overruns. Specifically, projects using BIM showed an average cost overrun of 5% versus 15% in non-BIM projects and a time overrun of 7% compared to 20% in non-BIM projects. Additionally, BIM enhances quality management and improves collaboration among stakeholders, leading to more efficient project execution. The study concludes that BIM is crucial for enhancing efficiency, sustainability, and overall performance in engineering project management. However, adoption challenges, particularly in developing regions, highlight the need for further research and strategies to support broader implementation. BIM’s ability to optimize resources and support informed decision-making makes it a key tool for the future of construction management.
Analysis of the coupling coordination of logistics development level and environmental support system in central China and its spatiotemporal evolution
Authors: Li Pan , Liu Yu 
Published: September 2024

Abstract
This research examines the synchronized progression of regional logistics and environmental support systems in China’s central region. Utilizing a comprehensive evaluation index system, the study employs a combination of entropy methods, TOPSIS analysis, and coupling coordination modeling to assess the development levels of regional logistics and environmental support systems across six central provinces from 2011 to 2020. The analysis focuses on comprehensive scores, coupling coordination degrees, and spatiotemporal evolution characteristics. The results indicate a synergistic relationship between the two systems in the six central provinces, with both comprehensive scores and coupling coordination D values demonstrating consistent growth over time. The study reveals a coordinated and orderly developmental pattern in the coupling and coordination relationship between the six provinces and the two systems within the central region. The overall degree of coupling and coordination in the central region exhibits a well-coordinated status, with provinces ranked as follows: Henan > Anhui and Hubei > Hunan > Shanxi and Jiangxi. This ranking demonstrates a spatial characteristic of high coordination in the middle and lower coordination at both extremities. The research identifies the underdeveloped state of regional logistics as the primary limiting factor. From the notable findings, this study’s conclusions offer valuable insights for policy formulation regarding the coordinated development of regional logistics and environmental support systems in China’s central region.
Navigating Legal and Ethical Boundaries: Safeguarding Personal Health Data in International Research Collaboration
Authors: Deng Zhaoxia 
Published: September 2024

Abstract
This study delves into the four characteristics of data accessibility across seven APEC countries, identifying key regulatory disparities in utilizing health-related data for medical research, including the potential reuse of health-related data, inconsistencies in anonymization or de-identification standards, and varied legal protection requirements based on the data’s origin. To foster cross-jurisdictional sharing of personal health data and fortify privacy security in China, this paper proposes the following strategies: implementing specialized legislation concerning health-related data, developing a Chinese version of the De-Identification Decision-Making Framework, leveraging advanced cryptographic privacy-preserving techniques in biomedical research, and employing data transfer and usage agreements.
Research on the Hybrid Teaching Model of Piano in Normal Universities Based on “OBE + Politics Integrated Courses”
Authors: Wang Hui 
Published: September 2024

Abstract
Teaching the piano, a vital element of artistic education is essential for developing students’ musical understanding and appreciation of beauty. Yet, conventional methods tend to focus excessively on technical proficiency, neglecting the development of students’ overall qualities. The challenge for educators is to incorporate ideological and political education into specialized courses. Outcome-Based Education (OBE) concentrates on the results of learning, highlighting the development of students’ competencies and the practical application of knowledge, while ideological and political curriculum education stresses the incorporation of ideological and political teaching into professional courses, fostering students’ awareness of social responsibility and historical duty. Based on these two educational concepts, this study designed an innovative piano teaching model and verified its effectiveness through teaching design, implementation, and effectiveness evaluation. Research has found that the experimental group students have significantly improved in basic skills, performance techniques, music understanding, expressiveness, learning attitude, and comprehensive evaluation. Students have a profound understanding of ideological and political education content, demonstrate a high level of interest, and possess the ability to integrate ideological and political education into daily learning.
Thermal-hydraulic analysis of a louver fin-and-tube radiator for a liquid–cooled PEMFC stack system
Authors: Ionescu Viorel 
Published: September 2024

Abstract
The present study aimed to develop a parametric analysis from the perspective of heat transfer and dimensionless pressure drop for a cross-flow heat exchanger with louvered fins and flat tubes. Four different radiator core models were considered here, with specific values of geometrical parameters as selected from the manufacturer’s datasheets. Effectiveness – the NTU (Number of Transfer Units) method was used to evaluate the total heat flux transferred between the cold and hot sides of the radiator. A possible application of the designed louvered fin radiator can be as a part of a liquid–cooling system for an automotive Proton Exchange Membrane Fuel Cell (PEMFC) stack with coolant flow rates of 1 l/min and 2 l/min, frontal air velocities up to 14 m/s and inlet temperatures for the coolant and air side of 343 K and 298 K, respectively. One of the radiator models investigated, having the lowest louver pitch to fin pitch ratio, highest fin length to fin pitch ratio and lowest louver length, showed the best thermo–hydraulic performance, with the highest surface goodness factor values along the entire Reynolds number domain.
One size fits most: On the emergence of differentiated regional policy in Poland
Authors: Dąbrowska Anna , Deegan Jason 
Published: September 2024

Abstract
In recent years, Poland has experienced exceptional and consistently high levels of economic growth. An important component of this growth has been the role played by regional policy. However, while Polish regions generally enjoy high levels of autonomy and have received considerable support from the EU, the changing structure and orientation of Polish regional development strategies remains an understudied area. This paper uses recent advances in the field of text mining to identify the similarity of regional strategies to identify whether Polish regions differentiate regional policy in their regional development strategies. Our results indicate that Polish regional development strategies have diverged significantly during the years covered by the two periods studied and that this degree of change appears to be strongly influenced by spatial factors. This increased divergence supports the notion of the greater use of differentiated regional policy in Poland.
Ökologische Zeigerwerte der Gefässpflanzen Österreichs
Authors: Karrer Gerhard 
Published: September 2024

Abstract
Ecological indicator values for Austrian vascular plants. Ecological indicator values of plants serve as indirect indicators for the status of ecological parameters in absence of physico-chemical measurements at place. Ellenberg introduced seven parameters which are namely light (L), temperature (T), continentality (K), moisture (F), reaction (R), nutrients (N), and salt (S), to define optima of plant growth under natural conditions along gradients scaled to nine levels. The moisture gradient is even extended to twelve levels and additional codes give information about the tolerance of facultative flooding or seasonal drought. Species that lack distinct optima and are present over a zone of more than four levels of the respective gradients are called indifferent (i). Plants that show optima situated towards both ends of the scale for parameters F and R are classified as bimodal (b) for the first time in national records of indicator values. Broad amplitudes and indistinct optima of species presences along the scales are not indicated separately due to the lack of available data. For 4902 vascular plants we provide indicator values that are valid for the Republic of Austria (holds for L, T, F, R, N, S). The values for continentality (K) consider the whole distribution area of the species. Comparisons with indicator value systems from neighboring countries show some shifts in the number of species assigned to the indicator levels but the histograms do not differ very much. Apparently, such shifts depend on the length of the ecological gradients available in the respective region but also on the regional pool of species and subspecific ecotypes.
Penyuluhan Penyuluhan Hukum Mengenai Implementasi Asuransi Perikanan Bagi Petani Tambak di Kalianyar, Bangil, Kabupaten Pasuruan
Authors: Salviana Fries Melia 
Published: September 2024

Penyuluh melakukan analisis terhadap Kelurahan Kalianyar sebagai berikut. Kalianyar sebagai kelurahan paling utara di Kecamatan Bangil, Pasuruan, Jawa Timur adalah sebuah wilayah di mana para penduduknya bekerja sebagai petani tambak yang menghasilkan ikan, udang, dan bandeng. Sebagai petani tambak, tentu saja terdapat beberapa permasalahan yang ada, diantaranya adalah terkait dengan pembayaran premi serta adanya pengajuan klaim yang rumit, di sisi lain juga adanya keluhan dari perusahaan asuransi tentang kerugian pembayaran klaim apabila terjadi evenemen yang berupa banjir. Sebab banjir merupakan evenemen yang terjadi setiap tahunannya. Untuk itulah, penyuluhan hukum ini memiliki tujuan untuk memerikan pengetahuan kepada petani tambak mengenai pentingnya asuransi. Sedangkan manfaat yang didapat, tidak hanya kepada petani tambak saja, akan tetapi juga kepada Dinas Perikanan Kabupaten Pasuruan yaitu nantinya akan menemukan cara yang efektif untuk mengurangi kerugian para petani tambak dengan bantuan dari asuransi yang agar tidak merugikan perusahaan asuransi, maka harus ada kesesuaian terkait dengan premi dan pembayaran ganti kerugian. Metode yang digunakan adalah, survei awal, penyuluhan hukum, dan survei akhir. Hasil yang dicapai adalah penambahan pengetahuan petani tambak mengenai asuransi perikanan serta pemahaman kepada Dinas Perikanan Kabupaten Pasuruan mengenai kebutuhan masyarakat agar nantinya tidak menderita kerugian terkait dengan pengelolaan tambak.
Konseling Individu Pendekatan Cognitife Behaviour Therapy Untuk Mengurangi Perilaku Menyimpang Pada Kasus Minuman Beralkohol dan Merokok Pada Remaja
Authors: Erawati Desi 
Published: September 2024

Kasus minuman keras maupun merokok dikalangan remaja secara umum di Kalimantan Tengah mencapai porsentase 243,8% berusia 15-24 tahun sudah sangat memprihatinkan. Perilaku kenakalan remaja atau Juvenile Delinquency adalah perilaku menyimpang yang berdampak pada kehadiran siswa di kelas dan penurunan prestasi akademik. Pentingnya bimbingan dan konseling melalui guru BK terhadap perilaku menyimpang remaja pada kasus tersbut, diharapakan dapat menurunkan juvenile delinquency dengan signifikan. Tujuan penulisan artikel ini adalah untuk menyajikan gambaran penanganan siswa dengan kasus miras dan merokok pada siswi SMK melalui BK individu dengan implementasi intervensi pendekatan CBT. Hasil dari BK individu siswi memahami dampak perilaku negatif, sehingga secara perlahan berhenti mengkonsumsi miras dan merokok, dan meningkatkan kualitas belajar di sekolah serta memiliki rencana masa depan .
PENGARUH KETIDAKPASTIAN LINGKUNGAN, FINANCIAL DISTRESS, CAPITAL INTENSITY DAN SALES GROWTH TERHADAP TAX AVOIDANCE DENGAN STRATEGI BISNIS SEBAGAI MODERASI
Authors: Iksan Khairul , Herawaty Vinola 
Published: September 2024

Penelitian ini bertujuan untuk memperoleh bukti empiris pengaruh Ketidakpastian Lingkungan, Financial Distress, Capital Intensity dan Sales Growth Terhadap Tax Avoidance dengan dimoderasi Strategi Bisnis. Populasi dalam penelitian ini adalah perusahaan Consumer Non-Cyclical yang telah terdaftar di Bursa Efek Indonesia (BEI) untuk tahun 2018 – 2023. Pengambilan sampel dilakukan dengan menggunakan purposive sampling. Metode pengambilan data sekunder yang digunakan adalah laporan keuangan dan laporan tahunan. Data dianalisis menggunakan EViews 12. Hasil penelitian ini menunjukan bahwa ketidakpastian lingkungan berpengaruh positif terhadap tax avoidance, sementara financial distress, capital intensity dan sales growth tidak berpengaruh terhadap tax avoidance, kemudian strategi bisnis sebagai variable moderasi dapat memperkuat pengaruh ketidakpastian lingkungan terhadap tax avoidance, namun tidak dapat memperkuat pengaruh financial distress, capital intensity, dan sales growth terhadap tax avoidance.