bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypogonadotropic Hypogonadism as First Presentation of the Severe Neuroendocrine Disorder Caused by RNF216
Authors: Rochtus Anne , Asscherickx Willeke , Timmers Marijke , Vermeer Sascha , Antonio Leen 
Published: October 2024

Abstract
Biallelic pathogenic variants in RNF216 cause a syndrome characterized by hypogonadotropic hypogonadism, cerebellar ataxia, chorea, and cognitive impairment, a combination first described as Gordon Holmes syndrome (MIM 212840). We report 2 siblings who were referred due to absent or delayed puberty. The older sibling, a 17-year-old male, presented with absence of secondary sexual characteristics and a high-pitched voice. He had normal cognitive development and no anosmia. Clinical examination revealed Tanner stage P1/G1 and bilateral gynecomastia. Blood tests showed low gonadotropin and morning testosterone levels. His 15-year-old sister was referred due to primary amenorrhea. She had spontaneous thelarche and presented with Tanner stage P3/B3. Pituitary magnetic resonance imaging was performed on the brother due to suspicion of Kallmann syndrome, revealing a normal anterior pituitary, a hypoplastic posterior pituitary, and an extensive supratentorial leuko-encephalopathy. Whole-exome sequencing revealed a homozygous pathogenic variant in RNF216 in both affected siblings. Both parents were heterozygous carriers. RNF216 pathogenic variants cause a disorder characterized by combined neurodegeneration and reproductive dysfunction. Although neurological symptoms are typically recognized first, they often seem to follow the onset of hypogonadism. This highlights the need for awareness, as hypogonadotropic hypogonadism may be the initial manifestation of this severe neuroendocrine disorder, especially in males.
Synchrotron X-ray imaging of soft biological tissues – principles, applications and future prospects
Authors: Albers Jonas , Svetlove Angelika , Duke Elizabeth 
Published: October 2024

ABSTRACT
Synchrotron-based tomographic phase-contrast X-ray imaging (SRµCT or SRnCT) is a versatile isotropic three-dimensional imaging technique that can be used to study biological samples spanning from single cells to human-sized specimens. SRµCT and SRnCT take advantage of the highly brilliant and coherent X-rays produced by a synchrotron light source. This enables fast data acquisition and enhanced image contrast for soft biological samples owing to the exploitation of phase contrast. In this Review, we provide an overview of the basics behind the technique, discuss its applications for biologists and provide an outlook on the future of this emerging technique for biology. We introduce the latest advances in the field, such as whole human organs imaged with micron resolution, using X-rays as a tool for virtual histology and resolving neuronal connections in the brain.
Photophysics of singlet oxygen generation in chitosan films with viburnum fruit extract (Viburnum opulus L.) under the influence of plasmons on a modified titanium surface
Authors: Tsibulnikova Anna V. , Zemlyakova Eugenia S. , Slezhkin Vasiliy A. , Samusev Ilya G. , Lyatun Ivan I. , Artamonov Dmitry A. , Zyubin Andrey Y. , Bryukhanov Valery V. 
Published: October 2024

Subject of study. This study investigates the luminescence spectral and kinetic features of singlet oxygen generation in chitosan microfilms (10 µm thick) embedded with an extract of viburnum fruit (Viburnum opulus L.). These films were deposited on both glass and gold film (80 µm thick), with the gold film electrochemically deposited on a rough, modified titanium surface. Aim of study. The aim was to determine the primary photophysical patterns of singlet oxygen dynamics in chitosan films containing viburnum fruit extract, following pulsed monochromatic photoexcitation by a structured titanium surface coated with electrochemically deposited gold. Method. The films were investigated in the visible and near-infrared regions using fluorescence techniques. The luminescence lifetime of Viburnum opulus L. flavonoids in the nanosecond range was measured using multichannel photon counting with a picosecond diode. The lifetime of the flavonoid triplet states and singlet oxygen phosphorescence in the studied extract in the microsecond range under excitation by a pulsed xenon lamp were also recorded. Main results. Long-lived delayed annihilation fluorescence of Viburnum opulus L. flavonoid molecules in the 590 nm spectral region, along with luminescence at 1272 nm attributable to singlet molecular oxygen, were observed. A comprehensive kinetic analysis was performed, considering the rate constants of photophysical processes involving singlet oxygen in films with viburnum fruit extract on rough gold surfaces under conditions of sample saturation with molecular oxygen. Stable generation of singlet oxygen was achieved in the chitosan microfilms containing viburnum fruit extract. Practical significance. The findings of this study can be applied to biological methods for cancer treatment.
Associations between the waist-to-height ratio index and migraine: A cross-section study of the NHANES 1999–2004
Authors: Jin Jing , Zheng Yafang , Gao Tianqi , Lin Xuanyu , Li Shi , Huang Chunyuan 
Published: October 2024

BackgroundThe importance of obesity as a factor that increases the probability of migraine episodes is increasingly acknowledged. Thus, this study aimed to explore the potential correlation between central obesity and migraine, emphasizing the waist-to-height ratio (WHtR) as a key measure in assessing this relationship.MethodsThis cross-sectional analysis included 13,344 individuals who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999–2004. To investigate the association associations between WHtR and migraine, we utilized refined multivariate logistic regression models, smoothing curve fitting methods, subpopulation analysis, and interactive testing.ResultsOf the 13,344 participants, 2,764 (20.72%) had migraines. A significant positive correlation was observed between the WHtR and migraine incidence in both the partially adjusted model (3.08 [95% CI: 1.92–4.94]) and the crude model (1.95 [95% CI: 1.23–3.08]). The participants in the highest quartile of the WHtR had a 13% greater incidence of migraine than those in the lowest quartile [1.13(0.99,1.28)]. The interaction analysis revealed a statistically significant difference (p<0.01) in this relationship among the subgroups. Notably, the correlation between WHtR and migraine risk was not significant and negative in patients ≥60 years, indicating that obesity has a mitigating role in preventing migraine in this elderly population.ConclusionsThe incidence of migraine increased concomitantly with increased WHtR. However, central obesity has a protective effect against migraine occurrence in individuals ≥60 years. Thus, our findings underscore the importance of WHtR in migraine prevention and management strategies and highlight its potential as a critical biomarker for mitigating migraine incidence.
Effects of religion, politics and distance to providers on HPV vaccine attitudes and intentions of parents in rural Utah
Authors: Lee Abigail A. , Skyles Ty J. , Jensen Jamie L. , Ord Brandon , Davis Spencer C. , East Matthew J. , Asay A. Eli , Obray Acelan M. , Syndergaard Tess , Davis Tyler , Nielson Bryce U. , Larson Ruth J. , Miner Dashiell S. , Hinton Kaitlyn , Zentz Lydia , Busacker Lydia , Poole Brian D. 
Published: October 2024

Purpose
Human papillomavirus (HPV) causes an estimated 300,000 high grade cervical dysplasias and 36,000 preventable cancers each year in the United States alone. Despite having a safe, effective and long lasting vaccine since 2006, the rate of uptake has been suboptimal, particularly in rural areas. In 2020, Utah ranked near last in teenage HPV vaccination rates with rural areas trailing urban areas by about 18 percent. In this study, we identified factors that affect the intent of rural Utah parents to vaccinate their children against HPV.

Methods
A survey was distributed electronically to Utah residents in rural areas. Recruitment was carried out through targeted advertising, community organizations, and professional survey panels. The survey was open from Nov. 15, 2022 to April 15, 2023. A total of 410 respondents were used for analysis. Survey results were analyzed using exploratory factor analysis, confirmatory factor analysis, and structural equation modeling.

Findings
Distance to care was shown to negatively influence direct intent to vaccinate, while trust in government, general vaccine attitudes, and HPV knowledge positively influence intent to vaccinate. It was found that religious practice decreased vaccine hesitancy while cautious sexual attitudes, distance to care, and general negative vaccine attitudes increased vaccine hesitancy. Conservative political identity and high income were both shown to decrease vaccine hesitancy as covariates.
CHEMICAL COMPOSITION AND NUTRITIVE VALUE OF GRASS, CONSERVED BY VARIOUS METHODS
Authors: ŽGAJNAR J. , LAVRENČIČ A. , STOPAR J. 
Published: October 2024

Chemical composition, apparent digestibility, degradability of dry matter and crude protein in the rumen at 1.5, 3, 6, 12, 24 and 48 hours after incubation, and the effective degradability of crude protein and nutritive value were established in deep frozen grass and in silages, made from unwilted grass, unwilted grass conserved with 0.4 % EnsimaxÒ , and wilted grass. When fresh unwilted grass (201 g per kg DM) was ensiled very carefully in 1 m3 silos, no significant differences in chemical composition, degradability, apparent digestibility and nutritive value were observed in comparison to silage conserved with EnsimaxÒ . Silage from wilted grass was significantly less digestible and had 17 % less digestible crude protein (DCP), starch equivalent (SE) and NEL (MJ) per kg DM compared to silage from unwilted grass.
On trialities and their absolute geometries
Authors: Leemans Dimitri , Stokes Klara , Tranchida Philippe 
Published: October 2024

Abstract
We introduce the notion of moving absolute geometry of a geometry with triality and show that, in the classical case where the triality is of type (I
σ) and the absolute geometry is a generalized hexagon, the moving 5 3 6 absolute geometry also gives interesting flag-transitive geometries with Buekenhout diagram for the groups G
2(k) and 3
D
4(k), for any prime power k ≥ 2. We also classify the absolute geometries for geometries with trialities but no dualities coming from maps of Class III with automorphism group L
2(q
3), where q ≥ 2 is prime power. We then investigate the moving absolute geometries for these geometries, illustrating their interest in this case.
University Library Collaboration in Belgium: Successes and Obstacles
Authors: Dekeyser Raf , Van Kiel Hilde 
Published: October 2024

Abstract
The paper starts with a description of the complexity of the Belgian nation and an overview of its universities. During the term of the authors’ librarianship at their university, there were regular meetings with their colleagues from the other universities, both at a national and a Flemish level. For both, a brief description is given of the actions originating from these collaborations. Nevertheless, these collaborations were also influenced negatively by the existing competitivity between their universities. At a national level, this led to a failure of the dream of installing a unified library management system. At a Flemish level, resentments were raised by the discussion on how to divide the funding that the Ministry of Education had allocated for the acquisition of digital journals.
Synthesis of novel meta-diamide compounds containing pyrazole moiety and their insecticidal evaluation
Authors: Liu Jiyong , Yan Yu , Wu Minghui , Xiang Juncheng , Pang Huailin , Li Bin , Lv Liang 
Published: October 2024

Abstract
A novel series of meta-diamide compounds incorporating a pyrazole moiety (2a–2v) were designed and synthesized based on cyproflanilide. Their structures were validated through 1H NMR, 13C NMR, and HRMS analyses. These compounds were evaluated for their insecticidal activity against Plutella xylostella, Mythimna separate, Tetranychus cinnabarinus, and Nilaparvata lugens. Most of the title compounds exhibited good activity against N. lugens at 400 mg/L. Compound 2k demonstrated potential for further optimization as an insecticidal lead, thereby extending the application of meta-diamide compounds in the field of sucking mouthparts.
Dialect levelling and merchant writing in Renaissance Italy
Authors: Brown Joshua 
Published: October 2024

Abstract
This article aims to assess the extent to which merchant language in Renaissance Italy can be said to have undergone a process of dialect levelling. Merchant letters in the Italian context are characterised by their high degree of verb allomorphy, both verbal and nominal. Previous investigations have shown that this degree of allomorphy is much more present in merchant texts than in other text genres immediately preceding codification in the 1500s. This article continues this line of research, showing how a process of dialect levelling occurs in a corpus of merchant writing sent from Milan in the late 1300s and early 1400s. Specifically, it focuses on 1pl. verb endings and the presence of voicing in past participles to show that Tuscan linguistic items infiltrated and then spread into neighbouring dialectal areas, such as Gallo-Italian, that is typologically distinct from Tuscan. Since this process of levelling was occurring at the same time as literary Tuscan was spreading, sometimes mediated also by merchants, the article also discusses these issues. While focus is placed on the contribution of merchant language in Renaissance Italy, the article can be seen as a case-study as evidence of language evolution ‘from below’. Overall, it argues that historical sociolinguistics provide powerful tools which help to show the various processes identified during standardization.
A pithos with Carian inscription from Mengefe settlement, north of the ancient city of Keramos, Caria
Authors: Kızıl Abuzer , Adiego Ignasi-Xavier 
Published: October 2024

Abstract
This article presents an edition and commentary of a hitherto unpublished Carian inscription found in the ancient settlement of Mengefe, north of Keramos, in 2008. The inscription is carved on the mouth of a pithos and consists of 58 readable signs. The text offers significant new information about Carian.
Lydian o-vocalism and the word for ‘rite, cult supply’
Authors: Billing Oscar , Sasseville David 
Published: October 2024

Abstract
Lydian o-vocalism has proved a difficult problem of historical phonology and the origin of many o-vowels remains unclear. In this paper, one sound law responsible for secondary o-vocalism is presented: the backing of an accented *á when adjacent to k. This sound law provides an etymology for the nominal suffix -oka- and can be supported by several independent data points. One consequence is the elucidation of the word kocwid as meaning ‘rite, cult supply’, leading to an improved understanding of three separate Lydian passages. An ongoing rounding of á to o when adjacent to f is also hypothesised, based on new evidence with observable a/o-vacillation.
Discourse-related expletives: Challenges and opportunities
Authors: Booth Hannah , Groothuis Kim A. 
Published: October 2024

Abstract
Recent research has highlighted the existence of expletive(-like) elements in various languages that are related to discourse, serving as fillers for designated topic/focus positions and/or contributing specific discourse–pragmatic effects. Such elements pose a number of challenges and opportunities, both for our overall conception of expletives and for our understanding of the syntax–discourse interface, although work in this area to date has mainly focused on the phenomenon in individual varieties. In this study, we critically survey the current state-of-the art on this topic and discuss four main areas where we see particular challenges and opportunities for research: (i) categories and definitions, (ii) typological correlations, (iii) theoretical modelling and (iv) language change. Overall, this article brings together a broad array of empirical findings and theoretical approaches on the phenomenon of discourse-related expletives and highlights the many avenues for future work in this area.
Literati or Demolition Men? References to Thoth in New Kingdom Epigraphy from the Precinct of Senwosret III at Dahshur
Authors: Navratilova Hana 
Published: October 2024

Summary
References to Thoth in New Kingdom epigraphy in the Middle Kingdom precinct of Senwosret III at Dahshur include two case studies: a literary dipinto and a depiction of an ibis. The fragmentary text might have contained a hymn to the god of writing, or a text resembling eulogy of the scribal profession. Alongside Kemyt, it attests to an emphasis on literacy and specialist knowledge. An image of Thoth articulated the allegiance to the patron of scribes. The New Kingdom writing and visual practices contribute to an understanding of the New Kingdom community involved in the use and destruction of the Middle Kingdom pyramid complex.
A Prayer to Horus Praising Edfu
Authors: Gabler Kathrin 
Published: October 2024

Summary
The article publishes a hieratic ostracon from the Ramesside Period, now stored in the magazine of the Ministry of Tourism and Antiquities at Elkab and probably found in (Hagr) Edfu. The text is a prayer to Horus and belongs to the literary genre known as the ‘praises of cities’. The first lines present a close parallel to Ostracon Nakhtmin 87/173, obverse, ll. 1–2, found in Theban Tomb 87; that ostracon bears a prayer to Amun and dates back to Dynasty 18. A comparison of both versions shows how easily such poems could be adapted and how the texts were passed on to later generations. On the Edfu ostracon, the copying work involved either a memory slip or perhaps a deliberate pun.
Kann Technik sanktionieren? Der technische Vollvollzug von Normen als soziologisches Problem
Authors: Barth Jonas , Egbert Simon 
Published: October 2024

Zusammenfassung
Angesichts der zunehmenden Autonomisierung von (algorithmischen) Technologien stellt sich immer stärker die Frage, wie solche Technologien zu regulieren sind und wie sich solche Technologien regulierend auf das menschliche Zusammenleben auswirken. Vor diesem Hintergrund wird in diesem Beitrag diskutiert, inwieweit Technologien eine sanktionierende Wirkung haben können und in welchen sozio-technischen Zusammenhängen von einer technischen Sanktionsleistung gesprochen werden kann. Im Zuge dessen werden rechtswissenschaftliche und techniksoziologische Diskussionen zusammengeführt und vor dem Hintergrund eines (rechts-)soziologischen Sanktionsbegriffs, der auf die enge Verbindung mit sozialen Normen verweist, mit Bezug auf die Beispiele autonome Waffensysteme und alkoholsensitive Wegfahrsperren, analysiert. Diese unterscheiden sich mit Blick auf ihre Regulierungsweise in zeitlicher, sachlicher und sozialer bzw. symbolischer Hinsicht. Es wird argumentiert, dass Technik in einigen Fällen in der Tat sanktionieren kann, sie aber oft lediglich eine Funktionalisierung von Normbezügen durchführt. Diese begriffliche und konzeptuelle Differenzierung scheint umso wichtiger, je breiter und stärker Algorithmen und Technik insgesamt ins gesellschaftliche Leben regulierend eingreifen.
Recomendações para o cuidado de enfermagem à autolesão entre adolescentes e jovens: revisão sistemática
Authors: Lopes Daniela Gonsalves , Costa Luiza Cesar Riani , Morais e Oliveira Ana Paula de , Fumincelli Lais , Oliveira Wanderlei Abadio de , Carlos Diene Monique 
Published: October 2024

Objetivo: mapear as recomendações para o cuidado de Enfermagem na autolesão não suicida entre adolescentes e jovens. Métodos: revisão sistemática, utilizando a meta-agregação para a síntese dos estudos com dados qualitativos, conforme recomendado pelo JBI. A busca foi conduzida nas bases LILACS e BDENF; MEDLINE; CINAHL; Web of Science; APA PsycInfo; EBSCOhost; Scopus Preview; Embase; e repositório PubMed Central. Resultados: foram incluídos 16 estudos, sendo identificados dois achados sintetizados. No primeiro, identificou-se a importância de relações permeadas pelo vínculo e confiança, livres de estigmas que envolvam o adolescente ou jovem como protagonistas. No segundo achado, emergiu a necessidade de formação adequada à Enfermagem, além do preparo físico dos diferentes serviços para acolher esta população em situação de autolesão. Conclusão: o cuidado necessita ser executado de forma humanizada, com a construção de confiança e em ambiente acolhedor. Deve-se focar em ações pautadas na comunidade e na lógica interprofissional e intersetorial. Contribuições para a prática: evidenciou-se a necessidade de sistematização de um cuidado individualizado, centrado no adolescente/jovem e família. A educação permanente e apoio em saúde mental da Enfermagem foram recomendados.
Pregnancy outcomes in type 2 versus type 1 diabetes: systematic review with meta-analyses
Authors: Drabløs Mari , Risstad Hilde , Alnæs-Katjavivi Patji , Qvigstad Elisabeth 
Published: October 2024

Objective
Increasing numbers of pregnancies are complicated by pregestational diabetes mellitus, especially type 2 diabetes (T2DM). Some studies have reported similar or greater risks of adverse pregnancy outcomes among women with T2DM relative to type 1 diabetes (T1DM). We aimed to compare the risk of four pregnancy complications: pre-eclampsia, preterm delivery, macrosomia, and perinatal mortality, in pregnant women with T2DM vs T1DM in high-income countries.

Design
Systematic review with meta-analyses.

Methods
Systematic literature searches in Medline and Embase were performed. We included observational studies with original data of outcome occurrence in both women with pregestational T2DM and T1DM. Two researchers independently evaluated full-text studies for inclusion and assessed the risk of bias using the Newcastle–Ottawa scale. Finally, we performed four meta-analyses.

Results
We included 35 publications in total. Meta-analyses demonstrated that, compared to T1DM, T2DM was associated with a lower risk of pre-eclampsia (risk ratio (RR): 0.76; 95% CI: 0.68–0.85), preterm delivery (RR: 0.69; 95% CI: 0.62–0.77), and macrosomia (RR: 0.75; 95% CI: 0.60–0.94). Perinatal mortality was more likely in pregnancies with T2DM (RR: 1.26; 95% CI: 1.06–1.50).

Conclusion
A summation of the research literature demonstrated that, compared to T1DM, women with T2DM had a lower risk of pre-eclampsia, preterm delivery, and macrosomia, but a higher risk of perinatal mortality.

Significance statement
Our review of pregnant women with diabetes suggests a higher risk of perinatal mortality for cases with maternal type 2 diabetes, even though the risks of pre-eclampsia, preterm delivery, and macrosomia were higher in cases with type 1 diabetes. Hence, the prevention of the development of type 2 diabetes and focus on improved gestational and diabetic care could be beneficial for fetal health.