bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and Safety of Non–Vitamin K Oral Anticoagulants in Comparison to Phenprocoumon: Data from 61,000 Patients with Atrial Fibrillation
Authors: Hohnloser Stefan , Basic Edin , Hohmann Christopher , Nabauer Michael 
Published: January 2018

AbstractAll pivotal trials have evaluated non–vitamin K oral antagonists (NOACs) against warfarin. However, in some regions of the world, phenprocoumon is the most widely used vitamin K antagonist (VKA). There is little evidence documenting effectiveness and safety of NOACs compared with phenprocoumon in atrial fibrillation (AF). A retrospective cohort study using a German claims database was conducted to assess effectiveness (stroke, systemic embolism [SE]) and safety (bleeding leading to hospitalization) during therapy with NOACs and phenprocoumon in 61,205 AF patients. Hazard ratios (HRs) for effectiveness and safety outcomes were derived from Cox proportional hazard models, adjusting for baseline characteristics. Propensity score matching was performed as a sensitivity analysis. As a prespecified subgroup analysis, the effects of reduced NOAC dosing were compared with phenprocoumon. A total of 61,205 patients were identified in whom phenprocoumon (n = 23,823, 38.9%), apixaban (n = 10,117, 16.5%), dabigatran (n = 5,122, 8.4%), or rivaroxaban (n = 22,143, 36.2%) was initiated. After adjusting for baseline confounders, all three NOACs tested had significantly lower risks of stroke/SE compared with phenprocoumon (apixaban—HR: 0.77, 95% CI: 0.66–0.90; dabigatran—HR: 0.74, 95% CI: 0.60–0.91; rivaroxaban—HR: 0.86, 95% CI: 0.76–0.97). Apixaban (HR: 0.58, 95% CI: 0.49–0.69) and dabigatran (HR: 0.64, 95% CI: 0.50–0.80) were associated with lower bleeding risks than phenprocoumon, whereas the risk was similar for rivaroxaban and phenprocoumon. All three NOACs showed reduced risk of intracranial bleeding compared with phenprocoumon. Reduced doses of NOACs were predominantly used in patients with advanced age and comorbidities with generally similar effectiveness and safety benefits compared with phenprocumon as standard-dose NOACs.
Augmented latissimus dorsi transfer: initial results in patients with massive irreparable posterosuperior rotator cuff tears
Authors: Sidler-Maier Claudia C. , Mutch Jennifer A. , Sidler Martin , Leivadiotou Dimitra , Payandeh Jubin B. , Nam Diane 
Published: January 2018

Background The surgical treatment of irreparable massive rotator cuff tears is challenging. The purpose of the present study was to report the initial outcomes after a modified latissimus dorsi transfer (LDT) augmented by acellular dermal allograft (ADA). Methods This retrospective study includes 24 patients managed with LDT using ADA augmentation as a bursal-sided onlay between March 2009 and December 2015. Results All patients were men with a mean age of 57 years (range 48 years to 70 years). Seven patients had a previously failed rotator cuff repair and ten patients presented with a deficient subscapularis tendon. At last follow-up (mean 27 months), there was a significant improvement in active forward flexion (mean increase 31°; p = 0.016), and abduction by 25° ( p = 0.059). The acromiohumeral distance remained stable and the failure rate was low (4%). Neither a history of previous rotator cuff surgery, nor the presence of a subscapularis tear had a negative impact on functional outcome. Conclusions In our cohort of patients, LDT augmented with ADA was a reasonable option for patients with previously failed rotator cuff repair, as well as in the subgroup of patients with a deficient subscapularis tendon. Level of evidence Level IV: Therapeutic study (case series)
Safety of Insulin Lispro and a Biosimilar Insulin Lispro When Administered Through an Insulin Pump
Authors: Thrasher James , Surks Howard , Nowotny Irene , Pierre Suzanne , Rotthaeuser Baerbel , Wernicke-Panten Karin , Garg Satish 
Published: January 2018

Background: SAR342434 (U100; SAR-Lis; insulin lispro) is a biosimilar/follow-on to insulin lispro (U100; Ly-Lis). Similar pharmacokinetics/pharmacodynamics between the two products has been demonstrated in a hyperinsulinemic euglycemic clamp study. The current study evaluated the safety of SAR-Lis and Ly-Lis when administered by continuous subcutaneous insulin infusion (CSII; insulin pumps). Methods: This was a randomized, open-label, 2 × 4-week, two-arm crossover study in 27 patients with type 1 diabetes mellitus (NCT02603510). The main outcome was the incidence of infusion set occlusions (ISOs), defined as failure to correct hyperglycemia (plasma glucose ≥≥ 300 mg/dl) by 50 mg/dl within 60 minutes by insulin bolus via the pump. Secondary outcomes included intervals between infusion set changes, treatment-emergent adverse events (TEAEs) including infusion site, hypersensitivity reactions and hypoglycemic events, and safety. Results: The number of patients reporting at least one ISO was small: 6/25 patients on SAR-Lis reported 14 ISOs and 4/27 on Ly-Lis reported nine ISOs. The estimated difference in ISO risk for SAR-Lis versus Ly-Lis was 7.9% (95% CI, –1.90 to 17.73). Mean interval between infusion set changes for any reason was similar with SAR-Lis (3.09 days) and Ly-Lis (2.95 days). The event rate (events/patient-month) of any hypoglycemia was similar with SAR-Lis (7.15) and Ly-Lis (7.98), as was the percentage of patients who experienced any TEAE (12.0% and 14.8%). Conclusion: Both SAR-Lis and Ly-Lis were well tolerated by patients using insulin pumps. The results do not suggest a clinically significant difference in the risk of ISO between SAR-Lis and Ly-Lis when used in CSII.
Vascular affection in relation to oxidative DNA damage in metabolic syndrome
Authors: Abd El Aziz Rokayaa , Fawzy Mary Wadie , Khalil Noha , Abdel Atty Sahar , Sabra Zainab 
Published: January 2018

Introduction: Obesity has become an important issue affecting both males and females. Obesity is now regarded as an independent risk factor for atherosclerosis-related diseases. Metabolic syndrome is associated with increased risk for development of cardiovascular disease. Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine concentration has been used to express oxidation status. Methods: Twenty-seven obese patients with metabolic syndrome, 25 obese patients without metabolic syndrome and 31 healthy subjects were included in our study. They were subjected to full history and clinical examination; fasting blood sugar (FBS), 2 hour post prandial blood sugar (2HPP), lipid profile, urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine and carotid duplex, A/B index and tibial diameters were all assessed. Results: There was a statistically significant difference ( p = 0.027) in diameter of the right anterior tibial artery among the studied groups, with decreased diameter of the right anterior tibial artery in obese patients with metabolic syndrome compared to those without metabolic syndrome; the ankle brachial index revealed a lower index in obese patients with metabolic syndrome compared to those without metabolic syndrome. There was a statistically insignificant difference ( p = 0.668) in the 8-oxodG in the studied groups. In obese patients with metabolic syndrome there was a positive correlation between 8-oxodG and total cholesterol and LDL. Conclusion: Urinary 8-oxodG is correlated to total cholesterol and LDL in obese patients with metabolic syndrome; signifying its role in the mechanism of dyslipidemia in those patients. Our study highlights the importance of anterior tibial artery diameter measurement and ankle brachial index as an early marker of atherosclerosis, and how it may be an earlier marker than carotid intima-media thickness.
Movement measurements at home for multiple sclerosis: walking speed measured by a novel ambient measurement system
Authors: Smith Victoria MJ , Varsanik Jonathan S , Walker Rachel A , Russo Andrew W , Patel Kevin R , Gabel Wendy , Phillips Glenn A , Kimmel Zebadiah M , Klawiter Eric C 
Published: January 2018

Background Gait disturbance is a major contributor to clinical disability in multiple sclerosis (MS). A sensor was developed to assess walking speed at home for people with MS using infrared technology in real-time without the use of wearables. Objective To develop continuous in-home outcome measures to assess gait in adults with MS. Methods Movement measurements were collected continuously for 8 months from six people with MS. Average walking speed and peak walking speed were calculated from movement data, then analyzed for variability over time, by room (location), and over the course of the day. In-home continuous gait outcomes and variability were correlated with standard in-clinic gait outcomes. Results Measured in-home average walking speed of participants ranged from 0.33 m/s to 0.96 m/s and peak walking speed ranged from 0.89 m/s to 1.51 m/s. Mean total within-participant coefficient of variation for daily average walking speed and peak walking speed were 10.75% and 10.93%, respectively. Average walking speed demonstrated a moderately strong correlation with baseline Timed 25-Foot Walk (rs = 0.714, P = 0.111). Conclusion New non-wearable technology provides reliable and continuous in-home assessment of walking speed.
Supporting the Sustainable Growth of SMEs with Content- and Collaboration-based Personal Knowledge Management Systems
Authors: Schmitt Ulrich 
Published: January 2018

Personal knowledge management (PKM) has been envisaged as a decentralising revolution and as the most important educational concern. Its root objective aims for highly knowledgeable individuals acting competently in their daily lives, as part of the workforce, and as public citizens. However, such a promising state of knowledge management (KM) has not emerged yet. Over the past four years, the ongoing development of a PKM concept and prototype system has been accompanied by over 30 multidisciplinary peer-reviewed publications. To verify the undertaking, dedicated articles have applied accepted general design science research (DSR) guidelines aimed at creating innovative IT artefacts (that extend human and social capabilities and meet desired outcomes), at validating design processes (as evidence of their relevance, utility, rigor, resonance and publishability) and at ensuring theory effectiveness (a matter of purposeful utility, content, communication and presentation). Based on the formation of individuals’ autonomous PKM capacities and personal devices nourished by networked creative conversations, the novel PKM approach, on the one hand, aims at advancing lifelong PKM support and academic and professional growth benefiting individuals as contributors and beneficiaries of institutional and societal performance. On the other hand, the scope of anticipated outcomes also offers appealing opportunities for further stakeholders engaged in the context of curation, education, research, development and business. In the latter context, prior papers have looked at the impact for large enterprises in regard to organizational knowledge management (OKM) system generations, the potential of a fruitful OKM–PKM–Co-evolution, and the promises for strengthening organisational capabilities of innovativeness and leadership. The focus of this article shifts to the collaborative and growth-related challenges of small and medium-sized enterprises (SMEs). It pinpoints the entrepreneurial barriers of organisational development, and how the PKM concept and its technological and educational devices are able—as any SME moves through its dynamic stages of growth, predicaments or decline—to guide and rectify the associated tasks and problems. These demands necessitate performing effectively under growing pressures and communicating with rising numbers of internal and external stakeholders, as affirmed in Garnsey’s resource-based notion of new firm growth, Greiner’s evolution–revolution-based stage-growth model, and Levie’s and Lichtenstein’s dynamic states approach to entrepreneurship.
Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group
Authors: Sakamoto Kenichi , Imamura Toshihiko , Kihira Kentaro , Suzuki Koji , Ishida Hisashi , Morita Hiromi , Kanno Miyako , Mori Takeshi , Hiramatsu Hidefumi , Matsubara Kousaku , Terui Kiminori , Takahashi Yoshihiro , Suenobu So-ichi , Hasegawa Daiichiro , Kosaka Yoshiyuki , Kato Koji , Moriya-Saito Akiko , Sato Atsushi , Kawasaki Hirohide , Yumura-Yagi Keiko , Hara Junichi , Hori Hiroki , Horibe Keizo 
Published: January 2018

Purpose Osteonecrosis (ON) is a serious complication of the treatment of childhood acute lymphoblastic leukemia (ALL); however, data relating to ON in Asian pediatric patients with ALL are scarce. Therefore, we performed a retrospective analysis of cohorts of Japanese patients with ALL to clarify the incidence, clinical characteristics, and risk factors of ON. Patients and Methods The incidence and characteristics of ON were determined in patients with ALL (n = 1,662) enrolled in two studies from the Japan Association of Childhood Leukemia Study (JACLS) group (n = 635 and n = 1,027 patients treated with the ALL-97 and ALL-02 protocols, respectively). Results In total, 24 of 1,662 patients suffered from ON, of which 12 of 635 and 12 of 1,027 patients were treated with the ALL-97 and the ALL-02 protocol, respectively. Of the 24 patients, 23 were older than 10 years. In multivariate analysis, age (≥ 10 years) was the sole significant risk factor for ON ( P < .001). Separate evaluation of patients ≥ 10 years of age indicated a 5-year cumulative incidence of ON of 7.2% (95% CI, 4.0% to 12.6%) and 5.9% (95% CI, 3.3% to 10.4%) in the ALL-97 and the ALL-02 protocol, respectively, which was lower than reported previously, despite an administration of dexamethasone (DEX) similar to that in comparable studies; however, concomitant administration of DEX and l-asparaginase was reduced in the JACLS protocols. Conclusion We identified a low frequency of ON in the JACLS ALL-97 and ALL-02 studies. Although the sole risk factor for ON was age (≥ 10 years), even among high-risk patients, ON incidence was significantly lower than that reported in previous studies. These results suggest that, not only the total amount of DEX, but also how DEX and l-asparaginase are administered, which affects the clearance of DEX, may be associated with ON incidence in patients with ALL.
Prenatal Dexamethasone Exposure Induced Ovarian Developmental Toxicity and Transgenerational Effect in Rat Offspring
Authors: Lv Feng , Wan Yang , Chen Yunxi , Pei Linguo , Luo Daji , Fan Guanlan , Luo Mengcheng , Xu Dan , Wang Hui 
Published: January 2018

AbstractPrenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian developmental toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d dexamethasone from gestational day (GD) 9 to GD20. A subgroup was euthanized for fetuses on GD20, and the other group went on to spontaneous labor to produce F1 offspring. The adult F1 females were mated with normal males to produce the F2 and F3 generations. The PDE fetal rats exhibited ovarian mitochondrial structural abnormalities, decreased serum estradiol (E2) levels, and lower expression levels of ovarian steroidogenic factor 1 (SF1), steroidal synthetases, and insulinlike growth factor 1 (IGF1). On postnatal week (PW) 6 and PW12, the PDE F1 offspring showed altered reproductive behavior and ovarian morphology. The serum E2 level and ovarian expression of SF1, steroidal synthetases, and IGF1 were also decreased. The adult F3 offspring showed alterations in reproductive phenotype and ovarian IGF1, SF1, and steroidal synthetase expression similar to those of F1. PDE induces ovarian developmental toxicity and transgenerational inheritance effects. The mechanism by which this toxicity occurs may be related to PDE-induced low-functional programming of fetal ovarian IGF1/SF1 and steroidal synthetases.
Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development
Authors: Soncin Francesca , Khater Marwa , To Cuong , Pizzo Donald , Farah Omar , Wakeland Anna , Arul Nambi Rajan Kanaga , Nelson Katharine K. , Chang Ching-Wen , Moretto-Zita Matteo , Natale David R. , Laurent Louise C. , Parast Mana M. 
Published: January 2018

ABSTRACT
An increasing body of evidence points to significant spatio-temporal differences in early placental development between mouse and human, but a detailed comparison of placentae in these two species is missing. We set out to compare placentae from both species across gestation, with a focus on trophoblast progenitor markers. We found that CDX2 and ELF5, but not EOMES, are expressed in early post-implantation trophoblast subpopulations in both species. Genome-wide expression profiling of mouse and human placentae revealed clusters of genes with distinct co-expression patterns across gestation. Overall, there was a closer fit between patterns observed in the placentae when the inter-species comparison was restricted to human placentae through gestational week 16 (thus, excluding full-term samples), suggesting that the developmental timeline in mouse runs parallel to the first half of human placental development. In addition, we identified VGLL1 as a human-specific marker of proliferative cytotrophoblast, where it is co-expressed with the transcription factor TEAD4. As TEAD4 is involved in trophectoderm specification in the mouse, we posit a regulatory role for VGLL1 in early events during human placental development.
Positive Mental Health from the perspective of Iranian society: A qualitative study
Authors: Mirabzadeh Arash , Baradaran Eftekhari Monir , Falahat Katayoun , Sajjadi Homeira , Vameghi Meroe , Ghaedamini Harouni Gholamreza 
Published: January 2018

Background: According to the World Health Organization, mental health relates, not only to the absence of mental disorder, but also to Positive Mental Health. Studies have shown that promoting positive mental health, not only reduces the prevalence and incidence of mental disorders, but also affects the process of treatment and reduces related burden. However, this concept has different interpretations in different cultures, and in many societies, mental health is still considered the absence of mental illness. Thus, the present study was conducted to provide an in-depth understanding of Iranian adults` perspective towards the concept of positive mental health. Materials and Methods: In the present qualitative study, eight focus group discussions (6 to 8 adults in each session) were held consisting of 30 to 60 year-old men and women from Tehran. Data were analyzed in "DeDoose" qualitative software using content analysis. Results: According to the data obtained, participants found no difference between positive mental health and mental health, mostly equating it to the absence of mental disorders and having positive energy, peace in and satisfaction with life. According to the results, positive mental health has four domains of emotional/psychological, spiritual, social, and life skills. Conclusion: Understanding an individual’s positive mental health concepts culturally and providing appropriate community based programs can significantly promote the mental health of the community.
A fruit fly model for studying paclitaxel-induced pain
Authors: Hamoudi Zina , Khuong Thang Manh , Cole Tiffany , Neely G. Gregory 
Published: January 2018

Background: Paclitaxel-induced peripheral neuropathy is a common and limiting side effect of an approved and effective chemotherapeutic agent. The cause of this nociception is still unknown. Methods: To uncover the mechanism involved in paclitaxel-induced pain, we developed a Drosophila thermal nociceptive model to show the effects of paclitaxel exposure on third instar larvae. Results: We found that paclitaxel increases pain perception in a dose-dependent manner, without overt morphological changes. Conclusions: Our simple, high throughput model can be combined with genomics approaches to identify regulators of chemotherapy-induced pain to eliminate its adverse side effects.
Normalisation of youth austerity through entertainment: critically addressing media representations of youth marginality in Britain
Authors: Blackman Shane , Rogers Ruth 
Published: January 2018

Blackman and Rogers presents a textual analysis of the media representations of young people in newspapers and TV reality programmes.
They argue that there has been a normalisation of youth austerity through entertainment.
Using film theory they assert that the ‘returned gaze’ of youth positioned in austerity, both challenges and pushes young people to the edges of society, but remains a populist representation of social crisis, used by both government and media to exert control over young adults.
They argue that selective visual imagery and a constructed language of fear shape the intersection of government policy and media coverage on young people.
They identify two zones of media representations: where young adults are projected as scroungers and marginalised through mockery and seen as a burden rather than an asset for society.
Veiled Intervention: Anti-Semitism, Allegory, and Captain America
Authors: Milford Mike 
Published: January 2018

Abstract
Conventional wisdom states that leftover frustrations from World War I necessitated an incremental rhetorical strategy for interventionists in the buildup to World War II. However, such considerations often miss another factor that bolstered American isolationism: anti-Semitism. In the interwar period, America saw a sharp uptick in anti-Semitic organizations that preached a vehement isolationist message. Because of this environment, interventionist rhetors, particularly Jewish rhetors, were denied access to traditional rhetorical resources. In response, one group turned to one of the few outlets available: comic books. Through allegory, a rhetorical form that combines an entertaining surface narrative with a strong but hidden ideological argument, these rhetors were able to reach broad audiences with interventionist messages from behind the veil of comic book adventures. This essay examines the ways in which one of those comic book characters, Captain America, was purposefully constructed to be an allegorical argument for intervention. Through a careful interplay of visuals and narrative themes, his creators made a compelling case for America’s involvement in the war.