bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL17A-Mediated Endothelial Breach Promotes Metastasis Formation
Authors: Kulig Paulina , Burkhard Sara , Mikita-Geoffroy Joanna , Croxford Andrew L. , Hövelmeyer Nadine , Gyülvészi Gabor , Gorzelanny Christian , Waisman Ari , Borsig Lubor , Becher Burkhard 
Published: January 2016

Abstract
The role of the IL23/IL17A axis in tumor–immune interactions is a matter of controversy. Although some suggest that IL17A-producing T cells (TH17) can suppress tumor growth, others report that IL17A and IL23 accelerate tumor growth. Here, we systematically assessed the impact of IL17A-secreting lymphocytes in several murine models of tumor lung metastasis. Genetic fate mapping revealed that IL17A was secreted within lung metastases predominantly by γδ T cells, whereas TH17 cells were virtually absent. Using different tumor models, we found Il17a−/− mice to consistently develop fewer pulmonary tumor colonies. IL17A specifically increased blood vessel permeability and the expression of E-selectin and VCAM-1 by lung endothelial cells in vivo. In transgenic mice, specific targeting of IL17A to the endothelium increased the number of tumor foci. Moreover, the direct impact of IL17A on lung endothelial cells resulted in impaired endothelial barrier integrity, showing that IL17A promotes the formation of lung metastases through tumor-endothelial transmigration. Cancer Immunol Res; 4(1); 26–32. ©2015 AACR.
Existential Antagonisms: Boundary Work and the Professional Ideology of Turkish Industrial Designers
Authors: Ilhan Ali O. , Er H. Alpay 
Published: January 2016

Industrial design (ID) is a fairly young and largely unknown profession in Turkey. Although significant developments have taken place in the field of ID in the past 15 years, the scope of scholarly attempts to analyze the sociological meaning of designing in the Turkish context is extremely limited. We use boundary work and professional ideology as salient concepts for a sociological understanding the ongoing professionalization process of Turkish industrial designers, who are developing professional identities and striving for recognition in the larger culture. This paper relies on 20 semi-structured interviews conducted with key players (i.e., ideologues) of the Turkish ID scene to analyze these boundary-work processes. We found that the positive collective identity of Turkish industrial designers is built on a formulation of negative others. These negative others are ideological antagonists that are pushed to the “other” side of the demarcation line. Negative others are especially dominant in the professional ideology of Turkish industrial designers because the perceived threats from these antagonists shape the collective consciousness. However, the construction of these others is an ambivalent process in which they also become ideological “friends.” We also demonstrate that professional ideology plays a pivotal role in producing, reproducing, and legitimizing claims of professionalism.
Storm-Scale Data Assimilation and Ensemble Forecasting with the NSSL Experimental Warn-on-Forecast System. Part II: Combined Radar and Satellite Data Experiments
Authors: Jones Thomas A. , Knopfmeier Kent , Wheatley Dustan , Creager Gerald , Minnis Patrick , Palikonda Rabindra 
Published: January 2016

Abstract
This research represents the second part of a two-part series describing the development of a prototype ensemble data assimilation system for the Warn-on-Forecast (WoF) project known as the NSSL Experimental WoF System for ensembles (NEWS-e). Part I describes the NEWS-e design and results from radar reflectivity and radial velocity data assimilation for six severe weather events occurring during 2013 and 2014. Part II describes the impact of assimilating satellite liquid and ice water path (LWP and IWP, respectively) retrievals from the GOES Imager along with the radar observations. Assimilating LWP and IWP observations may improve thermodynamic conditions at the surface over the storm-scale domain through better analysis of cloud coverage in the model compared to radar-only experiments. These improvements sometimes corresponded to an improved analysis of supercell storms leading to better forecasts of low-level vorticity. This positive impact was most evident for events where convection is not ongoing at the beginning of the radar and satellite data assimilation period. For more complex cases containing significant amounts of ongoing convection, only assimilating clear-sky satellite retrievals in place of clear-air reflectivity resulted in spurious regions of light precipitation compared to the radar-only experiments. The analyzed tornadic storms in these experiments are sometimes too weak and quickly diminished in intensity in the forecasts. The lessons learned as part of these experiments should lead to improved iterations of the NEWS-e system, building on the modestly successful results described here.
Family Involvement in Business and Financial Performance: A Panel Data Analysis
Authors: Gill Suveera , Kaur Parmjit 
Published: January 2016

Executive Summary The economic backdrop of most nations remains dominated by family businesses. Family control is common in publicly traded Indian companies. Such controlling families often hold large shareholdings and for the most part have representation at the top management level as well as on the board. Consequently, an overarching question that emerges is whether and how family ownership, management, and governance affect corporate performance. This article attempts to discern the relationship between family involvement in business (FIB) and financial performance (FP) of companies included in the S&P BSE 500 Index during the period 2006–2010. In addition, an attempt has been made to examine the difference in accounting and market measures of FP for family companies (FCs) vis-à-vis non-family companies (NFCs). A two-way fixed-effects panel model was used to examine the FIB–FP relationship with fixed effects being dummy variables for each year of the sample and dummy variables for each two-digit National Industrial Classification (NIC) code. Finally, to test for the ‘reverse causation’ between FIB and FP, the instrumental-variable—two-stage least-squares (IV-2SLS) regression was applied. The results confirm that FCs are a predominant form over a number of industries in a large sample, S&P BSE 500 Index. In addition, founding families are often involved in the actual management of the companies. Controlling for company-specific, industry affiliation, and corporate governance variables, the cross-sectional longitudinal analyses show that FIB is associated with superior FP. Furthermore, FP is higher for FCs vis-à-vis NFCs. Based on the market performance measure, FC appear to be better performers with higher outside board representations. On further analysis of the profile of independent directors, it was observed that they had a diverse background and expertise. The impact of firm size and unaffiliated blockholdings on FP was found to be significantly negative. Finally, the estimates from the IV-2SLS were found to be consistent with the preliminary results that FIB is associated with better FP. This article joins the evolving concurrence on the diversity and heterogeneity of family businesses by differentiating between family-owned, family-managed, and family-governed companies. It distinguishes itself from previous studies on the subject, as it uses different typologies based on the extent of FIB as well as presents multiple theoretical perspectives rather than a mono-theoretical view to empirical findings in the present study. Keeping this distinction in perspective is imperative for family business researchers, practitioners, and policymakers.
Triplet vs doublet lenalidomide-containing regimens for the treatment of elderly patients with newly diagnosed multiple myeloma
Authors: Magarotto Valeria , Bringhen Sara , Offidani Massimo , Benevolo Giulia , Patriarca Francesca , Mina Roberto , Falcone Antonietta Pia , De Paoli Lorenzo , Pietrantuono Giuseppe , Gentili Silvia , Musolino Caterina , Giuliani Nicola , Bernardini Annalisa , Conticello Concetta , Pulini Stefano , Ciccone Giovannino , Maisnar Vladimír , Ruggeri Marina , Zambello Renato , Guglielmelli Tommasina , Ledda Antonio , Liberati Anna Marina , Montefusco Vittorio , Hajek Roman , Boccadoro Mario , Palumbo Antonio 
Published: January 2016

Key Points
Triplet lenalidomide-based regimens did not induce any advantage over doublet lenalidomide-based regimens in elderly myeloma patients.
Diffany: an ontology-driven framework to infer, visualise and analyse differential molecular networks
Authors: Landeghem Sofie Van , Parys Thomas Van , Dubois Marieke , Inzé Dirk , de Peer Yves Van 
Published: January 2016

Abstract
Background
Differential networks have recently been introduced as a powerful way to study the dynamic rewiring capabilities of an interactome in response to changing environmental conditions or stimuli. Currently, such differential networks are generated and visualised using ad hoc methods, and are often limited to the analysis of only one condition-specific response or one interaction type at a time.

Results
In this work, we present a generic, ontology-driven framework to infer, visualise and analyse an arbitrary set of condition-specific responses against one reference network. To this end, we have implemented novel ontology-based algorithms that can process highly heterogeneous networks, accounting for both physical interactions and regulatory associations, symmetric and directed edges, edge weights and negation. We propose this integrative framework as a standardised methodology that allows a unified view on differential networks and promotes comparability between differential network studies. As an illustrative application, we demonstrate its usefulness on a plant abiotic stress study and we experimentally confirmed a predicted regulator.

Availability
Diffany is freely available as open-source java library and Cytoscape plugin from http://bioinformatics.psb.ugent.be/supplementary_data/solan/diffany/.
An efficient genome-wide association test for multivariate phenotypes based on the Fisher combination function
Authors: Yang James J. , Li Jia , Williams L. Keoki , Buu Anne 
Published: January 2016

Abstract
Background
In genome-wide association studies (GWAS) for complex diseases, the association between a SNP and each phenotype is usually weak. Combining multiple related phenotypic traits can increase the power of gene search and thus is a practically important area that requires methodology work. This study provides a comprehensive review of existing methods for conducting GWAS on complex diseases with multiple phenotypes including the multivariate analysis of variance (MANOVA), the principal component analysis (PCA), the generalizing estimating equations (GEE), the trait-based association test involving the extended Simes procedure (TATES), and the classical Fisher combination test. We propose a new method that relaxes the unrealistic independence assumption of the classical Fisher combination test and is computationally efficient. To demonstrate applications of the proposed method, we also present the results of statistical analysis on the Study of Addiction: Genetics and Environment (SAGE) data.

Results
Our simulation study shows that the proposed method has higher power than existing methods while controlling for the type I error rate. The GEE and the classical Fisher combination test, on the other hand, do not control the type I error rate and thus are not recommended. In general, the power of the competing methods decreases as the correlation between phenotypes increases. All the methods tend to have lower power when the multivariate phenotypes come from long tailed distributions. The real data analysis also demonstrates that the proposed method allows us to compare the marginal results with the multivariate results and specify which SNPs are specific to a particular phenotype or contribute to the common construct.

Conclusions
The proposed method outperforms existing methods in most settings and also has great applications in GWAS on complex diseases with multiple phenotypes such as the substance abuse disorders.
Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSV
Authors: Di mussi Rosa , Spadaro Savino , Mirabella Lucia , Volta Carlo Alberto , Serio Gabriella , Staffieri Francesco , Dambrosio Michele , Cinnella Gilda , Bruno Francesco , Grasso Salvatore 
Published: January 2016

Abstract
Background
Prolonged controlled mechanical ventilation depresses diaphragmatic efficiency. Assisted modes of ventilation should improve it. We assessed the impact of pressure support ventilation versus neurally adjusted ventilator assist on diaphragmatic efficiency.

Method
Patients previously ventilated with controlled mechanical ventilation for 72 hours or more were randomized to be ventilated for 48 hours with pressure support ventilation (n =12) or neurally adjusted ventilatory assist (n = 13). Neuro-ventilatory efficiency (tidal volume/diaphragmatic electrical activity) and neuro-mechanical efficiency (pressure generated against the occluded airways/diaphragmatic electrical activity) were measured during three spontaneous breathing trials (0, 24 and 48 hours). Breathing pattern, diaphragmatic electrical activity and pressure time product of the diaphragm were assessed every 4 hours.

Results
In patients randomized to neurally adjusted ventilator assist, neuro-ventilatory efficiency increased from 27 ± 19 ml/μV at baseline to 62 ± 30 ml/μV at 48 hours (p <0.0001) and neuro-mechanical efficiency increased from 1 ± 0.6 to 2.6 ± 1.1 cmH2O/μV (p = 0.033). In patients randomized to pressure support ventilation, these did not change. Electrical activity of the diaphragm, neural inspiratory time, pressure time product of the diaphragm and variability of the breathing pattern were significantly higher in patients ventilated with neurally adjusted ventilatory assist. The asynchrony index was 9.48 [6.38– 21.73] in patients ventilated with pressure support ventilation and 5.39 [3.78– 8.36] in patients ventilated with neurally adjusted ventilatory assist (p = 0.04).

Conclusion
After prolonged controlled mechanical ventilation, neurally adjusted ventilator assist improves diaphragm efficiency whereas pressure support ventilation does not.

Trial registration
ClinicalTrials.gov study registration: NCT0247317, 06/11/2015.
Patient outcomes following discharge from secure psychiatric hospitals: Systematic review and meta-analysis
Authors: Fazel Seena , Fimińska Zuzanna , Cocks Christopher , Coid Jeremy 
Published: January 2016

BackgroundSecure hospitals are a high-cost, low-volume service consuming around a fifth of the overall mental health budget in England and Wales.AimsA systematic review and meta-analysis of adverse outcomes after discharge along with a comparison with rates in other clinical and forensic groups in order to inform public health and policy.MethodWe searched for primary studies that followed patients discharged from a secure hospital, and reported mortality, readmissions or reconvictions. We determined crude rates for all adverse outcomes.ResultsIn total, 35 studies from 10 countries were included, involving 12 056 patients out of which 53% were violent offenders. The crude death rate for all-cause mortality was 1538 per 100 000 person-years (95% CI 1175–1901). For suicide, the crude death rate was 325 per 100 000 person-years (95% CI 235– 415). The readmission rate was 7208 per 100 000 person-years (95% CI 5916–8500). Crude reoffending rates were 4484 per 100 000 person-years (95% CI 3679–5287), with lower rates in more recent studies.ConclusionsThere is some evidence that patients discharged from forensic psychiatric services have lower offending outcomes than many comparative groups. Services could consider improving interventions aimed at reducing premature mortality, particularly suicide, in discharged patients.
FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice
Authors: Zhang Ting , Kim Dae Hyun , Xiao Xiangwei , Lee Sojin , Gong Zhenwei , Muzumdar Radhika , Calabuig-Navarro Virtu , Yamauchi Jun , Harashima Hideyoshi , Wang Rennian , Bottino Rita , Alvarez-Perez Juan Carlos , Garcia-Ocaña Adolfo , Gittes George , Dong H. Henry 
Published: January 2016

Abstract
β-Cell compensation is an essential mechanism by which β-cells increase insulin secretion for overcoming insulin resistance to maintain euglycemia in obesity. Failure of β-cells to compensate for insulin resistance contributes to insulin insufficiency and overt diabetes. To understand the mechanism of β-cell compensation, we characterized the role of forkhead box O1 (FoxO1) in β-cell compensation in mice under physiological and pathological conditions. FoxO1 is a key transcription factor that serves as a nutrient sensor for integrating insulin signaling to cell metabolism, growth, and proliferation. We showed that FoxO1 improved β-cell compensation via 3 distinct mechanisms by increasing β-cell mass, enhancing β-cell glucose sensing, and augmenting β-cell antioxidative function. These effects accounted for increased glucose-stimulated insulin secretion and enhanced glucose tolerance in β-cell-specific FoxO1-transgenic mice. When fed a high-fat diet, β-cell-specific FoxO1-transgenic mice were protected from developing fat-induced glucose disorder. This effect was attributable to increased β-cell mass and function. Furthermore, we showed that FoxO1 activity was up-regulated in islets, correlating with the induction of physiological β-cell compensation in high-fat-induced obese C57BL/6J mice. These data characterize FoxO1 as a pivotal factor for orchestrating physiological adaptation of β-cell mass and function to overnutrition and obesity.
Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction
Authors: Lu Wenshu , Chen Qiongyu , Ying Songmin , Xia Xiaobing , Yu Zhanru , Lui Yuan , Tranter George , Jin Boquan , Song Chaojun , Seymour Leonard W. , Jiang Shisong 
Published: January 2016

ABSTRACT
TNF is a primitive protein that has emerged from more than 550 million years of evolution. Our bioinformatics study of TNF from nine different taxa in vertebrates revealed several conserved regions in the TNF sequence. By screening overlapping peptides derived from human TNF to determine their role in three different TNF-induced processes – apoptosis, necrosis and NF-κB stimulation – we found that TNF conserved regions are mostly related to cell death rather than NF-κB stimulation. Among the most conserved regions, peptides (P)12, P13 and P1213 (comprising P12 and P13) induced apoptosis, whereas P14, P15, P16 and P1516 (comprising P15 and P16) induced necrosis. Cell death induced by these peptides was not through binding to the TNF receptor. P16-induced necrosis was mainly through disruption of the cell membrane, whereas P1213-induced apoptosis involved activation of TRADD followed by formation of complex II. Finally, using a monoclonal antibody and a mutant TNF protein, we show that TNF-induced apoptosis is determined by a conserved linear sequence that corresponds to that within P1213. Our results reveal the determinant sequence that is key to the TNF primitive function of inducing apoptosis.
Multifunctional Abl kinases in health and disease
Authors: Khatri Aaditya , Wang Jun , Pendergast Ann Marie 
Published: January 2016

ABSTRACT
The Abelson tyrosine kinases were initially identified as drivers of leukemia in mice and humans. The Abl family kinases Abl1 and Abl2 regulate diverse cellular processes during development and normal homeostasis, and their functions are subverted during inflammation, cancer and other pathologies. Abl kinases can be activated by multiple stimuli leading to cytoskeletal reorganization required for cell morphogenesis, motility, adhesion and polarity. Depending on the cellular context, Abl kinases regulate cell survival and proliferation. Emerging data support important roles for Abl kinases in pathologies linked to inflammation. Among these are neurodegenerative diseases and inflammatory pathologies. Unexpectedly, Abl kinases have also been identified as important players in mammalian host cells during microbial pathogenesis. Thus, the use of Abl kinase inhibitors might prove to be effective in the treatment of pathologies beyond leukemia and solid tumors. In this Cell Science at a Glance article and in the accompanying poster, we highlight the emerging roles of Abl kinases in the regulation of cellular processes in normal cells and diverse pathologies ranging from cancer to microbial pathogenesis.
The Measure of the Effectiveness of E - Learning by using Academic Scientific Materials which are Available on the Internet : Analytical and Descriptive Study in Al – Mustansiriya University According to (NOURI- NET ) System
Authors: Hassan Haider 
Published: January 2016

The study aims to measure the effect of using academic scientific materials on the World Wide Web in education , through the Availability educational materials , and displayed an electronically using software (NOURI- NET ) to evaluate the web-based course in terms of its of use and the acceptance which are used by students the level of benefit, and the study surveyed (70) students in all disciplines at the Al-mustansiriya university during (2010 –2011) by using methods of scale(likert) to collect information about learners associated with variables of the study.
The result of this study reveals that the students acceptance of the web-based instruction was high and the use of the web-based materials positively affects the learning skills of the students . however , functional problems were found in terms of using the web –based materials .
The knowledge enabling at the university library: Towards an effective management of competencies in the knowledge society
Authors: Kahlaa Samraa , Chabounia Omar 
Published: January 2016

This study aims to deepening the comprehension of the reality of knowledge and its management which necessitates a knowledge about management that takes the individual and the tacit knowledge he possesses as two faces for the valuable currency of superiority taking university libraries in Batna a model for our study that can be considered as necessary steps to rely on, A great consideration is given to knowledge till has become an important aspect of its practices that is to say Knowledge Management, The maturity of the knowledge working grows when the individual can do what he knows through Enabling knowledge.
Employment and Economic Self-Sufficiency:2015 National Goals for Research, Policy, and Practice
Authors: Nord Derek , Barkoff Allison , Butterworth John , Carlson Dawn , Cimera Robert , Fabian Ellen , Grossi Teresa , Hall Allison , Lucus Jonathan , Nye-Lengerman Kelly , Gower Wendy Strobel , Tyree Milton , Von Schrader Sarah , Wohl Allison 
Published: January 2016

Abstract
Employment in general workforce and economic self-sufficiency continue to be the exceptions for people with intellectual and developmental disabilities (IDD), rather than the norm. Research, policy, and practice can and should play a coordinated role in solving this problem. This article summarizes the methods used and the consensus-based national goals identified to guide the direction of the field that were developed by experts in the field. A discussion of the implications of the findings is also provided, including the need for advocacy to advance the goals.