bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychiatric neurosurgery in the 21st century: overview and the growth of deep brain stimulation
Authors: Barrett Kenneth 
Published: October 2017

SummaryAmbulatory deep brain stimulation (DBS) became possible in the late 1980s and was initially used to treat people with movement disorders. Trials of DBS in people with treatment-resistant psychiatric disorder began in the late 1990s, initially focusing on obsessive-compulsive disorder, major depressive disorder and Tourette syndrome. Despite methodological issues, including small participant numbers and lack of consensus over brain targets, DBS is now being trialled in a wide range of psychiatric conditions. There has also been more modest increase in ablative procedures. This paper reviews these developments in the light of contemporary brain science, considers future directions and discusses why the approach has not been adopted more widely within psychiatry.
Modernizing Clinical Trial Eligibility Criteria: Recommendations of the American Society of Clinical Oncology–Friends of Cancer Research HIV Working Group
Authors: Uldrick Thomas S. , Ison Gwynn , Rudek Michelle A. , Noy Ariela , Schwartz Karl , Bruinooge Suanna , Schenkel Caroline , Miller Barry , Dunleavy Kieron , Wang Judy , Zeldis Jerome , Little Richard F. 
Published: October 2017

Purpose People with HIV are living longer as a result of effective antiretroviral therapy. Cancer has become a leading cause of morbidity and mortality in this patient population. However, studies of novel cancer therapeutics have historically excluded patients with HIV. Critical review of eligibility criteria related to HIV is required to accelerate development of and access to effective therapeutics for HIV-infected patients with cancer and make studies more generalizable to this patient population. Methods From January through April 2016, the HIV Working Group conducted a series of teleconferences; a review of 46 New Drug Applications from registration studies of unique agents studied in adults with cancer that led to the initial US Food and Drug Administration approval of that agent from 2011 to 2015; and a review of HIV-related eligibility criteria from National Cancer Institute–sponsored studies. Results were discussed and refined at a multistakeholder workshop held May 12, 2016. The HIV Working Group developed recommendations for eligibility criteria that focus on pharmacologic and immunologic considerations in this patient population and that balance patient safety, access to appropriate investigational agents, and study integrity. Results Exclusion of patients with HIV remains common in most studies of novel cancer agents. Models for HIV-related eligibility criteria in National Cancer Institute–sponsored studies are instructive. HIV infection itself should no longer be an exclusion criterion for most studies. Eligibility criteria related to HIV infection that address concurrent antiretroviral therapy and immune status should be designed in a manner that is appropriate for a given cancer. Conclusion Expanding clinical trial eligibility to be more inclusive of patients with HIV is justified in most cases and may accelerate the development of effective therapies in this area of unmet clinical need.
Modernizing Clinical Trial Eligibility Criteria: Recommendations of the American Society of Clinical Oncology–Friends of Cancer Research Brain Metastases Working Group
Authors: Lin Nancy U. , Prowell Tatiana , Tan Antoinette R. , Kozak Marina , Rosen Oliver , Amiri-Kordestani Laleh , White Julia , Sul Joohee , Perkins Louise , Beal Katherine , Gaynor Richard , Kim Edward S. 
Published: October 2017

Purpose Broadening trial eligibility to improve accrual and access and to better reflect intended-to-treat populations has been recognized as a priority. Historically, patients with brain metastases have been understudied, because of restrictive eligibility across all phases of clinical trials. Methods In 2016, after a literature search and series of teleconferences, a multistakeholder workshop was convened. Our working group focused on developing consensus recommendations regarding the inclusion of patients with brain metastases in clinical trials, as part of a broader effort that encompassed minimum age, HIV status, and organ dysfunction. The working group attempted to balance the needs of protecting patient safety, facilitating access to investigational therapies, and ensuring trial integrity. On the basis of input at the workshop, guidelines were further refined and finalized. Results The working group identified three key populations: those with treated/stable brain metastases, defined as patients who have received prior therapy for their brain metastases and whose CNS disease is radiographically stable at study entry; those with active brain metastases, defined as new and/or progressive brain metastases at the time of study entry; and those with leptomeningeal disease. In most circumstances, the working group encourages the inclusion of patients with treated/stable brain metastases in clinical trials. A framework of key considerations for patients with active brain metastases was developed. For patients with leptomeningeal disease, inclusion of a separate cohort in both early-phase and later-phase trials is recommended, if CNS activity is anticipated and when relevant to the specific disease type. Conclusion Expanding eligibility to be more inclusive of patients with brain metastasis is justified in many cases and may speed the development of effective therapies in this area of high clinical need.
Physical function and health-related quality of life in young adults with unilateral congenital lower-limb deficiencies
Authors: Kaastad T. S. , Tveter A. T. , Steen H. , Holm I. 
Published: October 2017

Purpose The primary aim was to examine if there were differences in physical function and health-related quality of life (HRQoL) between young adults (18 to 35 years) with unilateral congenital lower-limb deficiency (CLLD) who had been surgically lengthened (Surg) and those using lengthening prostheses (Pros). Second, we wanted to compare their health status with an age- and gender-matched reference group (Ref) without CLLD. Methods Cross-sectional study including a study-specific questionnaire, clinical examination, two field tests evaluating physical function (the six-minute walk test and the Stair test) and HRQoL questionnaires (Short Form (SF)-36 and EuroQol (EQ)-5D-3L). Results Physical function and HRQoL did not differ between the two treatment groups. The odds for having painful or disfiguring scars were 18 times higher in the Surg group (n = 16) compared with the Pros group (n = 14). The CLLD group showed significantly reduced physical function compared with the Ref group. HRQoL, measured by the EQ-5D-3L visual rating scale, was significantly reduced in the CLLD group compared with the Ref group, as was the SF-36 physical function domain in both genders. Men with CLLD also showed increased bodily pain and reduced general health (SF-36), while we found a reduction in the emotional role domain in women compared with Ref. Conclusion There were no significant differences in physical function and quality of life in young adults with CLLD treated with surgical lengthening compared with those using lengthening prostheses. Compared with the general Norwegian population, young adults with CLLD had significantly lower physical function and reduced HRQoL in some domains.
Obstacles to reduction in infantile developmental dysplasia of the hip
Authors: Studer K. , Williams N. , Studer P. , Baker M. , Glynn A. , Foster B. K. , Cundy P. J. 
Published: October 2017

Purpose Identification of anatomical structures that block ­reduction in developmental dysplasia of the hip (DDH) is ­important for the management of this challenging condition. Obstacles to reduction seen on arthrogram are well-known. However, despite the increasing use of MRI in the assessment of adequacy of reduction in DDH, the interpretation of MRI patho-anatomy is ill-defined with a lack of relevant literature to guide clinicians. Method This is a retrospective analysis of the MRI of patients with DDH treated by closed reduction over a five-year period (between 2009 and 2014). Neuromuscular and genetic disorders were excluded. Each MRI was analysed by two orthopaedic surgeons and a paediatric musculoskeletal radiologist to identify the ligamentum teres, pulvinar, transverse acetabular ligament (TAL), capsule, labrum and acetabular roof cartilage hypertrophy. Inter- and intraobserver reliability was calculated. The minimum follow-up was 12 months. Results A total of 29 patients (38 hips) underwent closed reduction for treatment of DDH. Eight hips showed persistent subluxation on post-operative MRI. Only three of these eight hips showed an abnormality on arthrogram. The pulvinar was frequently interpreted as ‘abnormal’ on MRI. The main obstacles identified on MRI were the ligamentum teres (15.8%), labrum (13.1%) and acetabular roof cartilage hypertrophy (13.2%). The inter-rater reliability was good for TAL, capsule and pulvinar; moderate for ligamentum teres and labrum; and poor for hypertrophied cartilage. Conclusion The labrum, ligamentum teres and acetabular roof cartilage hypertrophy are the most important structures seen on MRI preventing complete reduction of DDH. Focused interpretation of these structures may assist in the management of DDH.
Spinal canal dimensions affect outcome of adolescent disc herniation
Authors: Linkoaho O. , Kivisaari R. , Ahonen M. 
Published: October 2017

Purpose Small spinal canal dimensions play a role in symptomatic adult disc herniation, but its role in adolescent disc herniation has not been investigated with MRI. The goal of this study was to examine retrospectively if there is a correlation with dimensions of osseous spinal canal and need of discectomy in an adolescent population suffering from disc herniation. Methods A retrospective review of child and adolescent patients who were treated in our institution for back or back-­related leg pain was conducted. Patients were divided in three groups; group 1: lumbar disc herniation requiring operative treatment; group 2: lumbar disc herniation treated with observation; and group 3: back pain and no disc herniation on MRI. MRI images and radiographs were studied for spinal canal dimensions and compared between groups. Results The discectomy group presented considerably smaller spinal canal dimensions measured from the MRI images than the two other groups. Conclusion Adolescent patients requiring operative treatment for symptomatic disc herniation have smaller osseous spinal canals than patients who are managed non-operatively.
Kringle IV Type 2, Not Low Lipoprotein(a), as a Cause of Diabetes: A Novel Genetic Approach Using SNPs Associated Selectively with Lipoprotein(a) Concentrations or with Kringle IV Type 2 Repeats
Authors: Tolbus Andra , Mortensen Martin B , Nielsen Sune F , Kamstrup Pia R , Bojesen Stig E , Nordestgaard Børge G 
Published: October 2017

Abstract

BACKGROUND
Low plasma lipoprotein(a) concentrations are associated with type 2 diabetes. Whether this is due to low lipoprotein(a) concentrations per se or to a large number of kringle IV type 2 (KIV-2) repeats remains unclear. We therefore aimed to identify genetic variants associated selectively with lipoprotein(a) concentrations or with the number of KIV-2 repeats, to investigate which of these traits confer risk of diabetes.

METHODS
We genotyped 8411 individuals from the Copenhagen City Heart Study for 778 single-nucleotide polymorphisms (SNPs) in the proximity of the LPA gene, and examined the association of these SNPs with plasma concentrations of lipoprotein(a) and with KIV-2 number of repeats. SNPs that were selectively associated with lipoprotein(a) concentrations but not with KIV-2 number of repeats, or vice versa, were included in a Mendelian randomization study.

RESULTS
We identified 3 SNPs (rs12209517, rs12194138, and rs641990) that were associated selectively with lipoprotein(a) concentrations and 3 SNPs (rs1084651, rs9458009, and rs9365166) that were associated selectively with KIV-2 number of repeats. For SNPs selectively associated with lipoprotein(a) concentrations, an allele score of 4–6 vs 0–2 had an odds ratio for type 2 diabetes of 1.03 (95% CI, 0.86–1.23). In contrast, for SNPs selectively associated with KIV-2 number of repeats, an allele score of 4–6 vs 0–2 had an odds ratio for type 2 diabetes of 1.42 (95% CI, 1.17–1.69).

CONCLUSIONS
Using a novel genetic approach, our results indicate that it is a high number of KIV-2 repeats that are associated causally with increased risk of type 2 diabetes, and not low lipoprotein(a) concentrations per se. This is a reassuring finding for lipoprotein(a)-lowering therapies that do not increase the KIV-2 number of repeats.
Parallel worlds: A computerized textual analysis of abstracts published in major journalism studies journals 2000–11
Authors: Cokley John , Tilley Elspeth , Hetherington Susan , Angus Daniel , Taylor Annie 
Published: October 2017

Abstract
A total of 1018 English-language abstracts in the field of journalism studies, published from 2000–2011 in three internationally peer-reviewed journals, were subjected to computerized textual analysis and manual (human) discourse analysis to discover trends. The project aimed to build on previous studies and to describe what the researchers expected would be a new consensus snapshot among editors and top-level reviewers of the evolution and direction of Journalism Studies in the English-speaking world. Expected results emerged and are presented in detail: national priorities dominate two of the three journals while international and generally theoretical themes dominate the third. However, an unexpected result was that while the three journals contain identifiable themes in journalism studies over the twelve years examined, there was negligible evidence of interaction between these themes within or between the journals. Systems theory suggests that the ‘journalism’ itself, which has been the target of the ‘studies’ has been experiencing a period of stagnation and that very little, if any, overall interaction, discipline development and change has taken place. We argue that a root cause for this is the lack of professional leadership in journalism.
‘Ghana in the Eyes of God’: Media ecology and the Anas journalistic investigation of Ghana’s judiciary
Authors: Odartey-Wellington Felix , Anas Anas Aremeyaw , Boamah Percy 
Published: October 2017

Abstract
In September 2015, investigative journalist Anas Aremeyaw Anas revealed covertly gathered audio-visual evidence of judicial corruption in Ghana. We contextualize the journalistic investigation that resulted in what became known as the ‘judges scandal’ in media ecology, emphasizing the importance of digital technologies to the investigation. From a discourse analysis of media reportage, we argue that public focus on the human agency implicated in the investigation is unmatched by conversations regarding the impact of new communication technologies that facilitated the investigation. We suggest a conversational expansion to consider ramifications of new digital communication technologies for social power relations in Ghana, and the potential for holding public office holders to account. By highlighting communication technology as a factor, we direct attention to a potential area for intervention by way of journalistic activity and civil society capacity building in Ghana.
Palestinian journalists, professional values and the negotiation of identity
Authors: Robins Melinda B. , Roushanzamir Elizabeth Lester 
Published: October 2017

Abstract
The world of the Palestinian journalist is complex, difficult and emotional. This project examines how journalists trained in what Americans would consider conventional professional values see themselves. A survey of 75 Palestinian journalists is augmented by the self-reports of sixteen long interviews that give insight into the negotiation of personal and professional identities.
Early Western Writing, Sensory Modalities, and Modern Alphabetic Literacy: On the Origins of Representational Theorizing
Authors: Anton Corey 
Published: October 2017

Abstract
This article interrogates the so-called “crisis in representation” as a symptom of forgotten alphabetic literacy. My analysis launches its critique by attending to John Stewart’s recent writings on “the symbol model” and advances through two main sections. The first reviews historical developments in alphabetic technologies, identifying both basic differences and early impacts. The second section addresses phenomenological differences between hearing and vision and attempts to document how alphabetic writing enables speech to be heard as it could be seen if it were written. In summary, I try to demonstrate how literacy, the modern condition of logos, inseparably fuses with “oral/aural articulate contact.”
The use of music in mutual recovery: A qualitative pilot study
Authors: Callahan Kiley , Schlozman Steven , Beresin Eugene , Crawford Paul 
Published: October 2017

Abstract
Mutual recovery involves caregivers and their clients mutually participating in artistic endeavours to foster resilience in both parties. A qualitative enquiry into the use of group music making (referred to as a ‘Music Jam’) between both the caregivers and clients at a residential treatment facility for adults with developmental disabilities and schizophrenia was conducted. The purpose of this study was to examine whether shared musical endeavours enjoyed therapeutic and resilience building utility for both the caregivers and clients. A focus group was conducted in which comments were collected and transcribed for qualitative analysis. Themes of enhanced respect and equality among clients for the caregivers, and intrapersonal connectedness and enhanced feelings of community emerged during analysis. Both parties expressed recurrent themes of humility, mutual respect and overall enjoyment. Mutual recovery practices where caregivers and their clients play music outside of therapeutic settings are an effective means by which resiliency and connectedness can be enhanced in all participants. To this end, other forms of mutual recovery deserve greater investigation in order to better examine whether these practices are worth implementing in larger and more varied formats.
Reviews
Authors: Jones Jonathan , Byrne Libby , Derrington Philippa , Blair Erin , Meyers Carmen 
Published: October 2017

Abstract
Into the Story 2: More Stories! More Drama!, Carole Miller and Juliana Saxton (2016) Bristol, UK: Intellect, 238 pp., ISBN: 9781783205745, p/bk, $43.00
Embroidered Cancer Comic, Sima Elizabeth Shefrin (2016) London: Singing Dragon, 32 pp., ISBN: 9781848192898, p/bk, £7.99
Rhythm to Recovery: A Practical Guide to Using Rhythmic Music, Voice and Movement for Social and Emotional Development, Simon Faulkner (2017) London and Philadelphia, PA: Jessica Kingsley Publishers, 256 pp., ISBN: 9781785921322, p/bk, $29.95
Art-Based Group Therapy: Theory and Practice, 2nd ed., Bruce Moon (2016) Chicago, IL: Charles C. Thomas Publishers Ltd., 258 pp., ISBN: 9780398091156, p/bk, $38.95; ISBN: 9780398091163, e-book $38.95
Theatre in Education in Britain: Origins, Development and Influence, Roger Wooster (2016) London and New York: Bloomsbury Methuen Drama, 312 pp., ISBN: 9781472591494, p/bk, $19.79
Promoting young people’s mental health and well-being through participation in the arts: A mixed-methods service evaluation of the Zinc Arts ArtZone programme
Authors: Wilson Ceri , Sharpe Darren 
Published: October 2017

Abstract
Arts-for-health initiatives are associated with improvements in mental health, wellbeing and social inclusion; however, research amongst young people is sparse. The aim of the study was to conduct a mixed-methods evaluation of a participatory arts programme for young people with, or at risk of, mental ill health. The Zinc Arts ArtZone programme involved working with individuals aged 11–25 in south-east England, engaging them in arts activities over ten-week courses in community and secure unit settings. 122 course participants completed pre/post measures of mental illness severity and well-being, and 34 participants took part in interviews and focus groups. Mental illness severity significantly decreased and mental well-being significantly increased. Participants reported social and emotional benefits including decreased social isolation and increased social inclusion and mental well-being. Participatory arts interventions may serve as a useful tool in tackling increasing mental ill health amongst young people.
Remixing identity: Creating meaning from songs written by patients recovering from a spinal cord injury
Authors: Viega Michael , Baker Felicity A. 
Published: October 2017

Abstract
Physical trauma that leads to a spinal cord injury can have a devastating impact on a patient’s self-identity. Therapeutic songwriting has been found to decrease symptoms of depression and increase self-concept for people who find themselves having to reconstruct their identity after experiencing a spinal cord injury following a traumatic accident. This study examines the developmental processes of self-concept through an arts-based analysis of songs (N=27) written by adult patients (N=9) who are in rehabilitation due to a road traffic injury. Four composite character portraits were revealed from the arts-based analysis, and the results are reconstructed as music compositions, which were created from sampling the original songs. Each character represents various stages of identity development post-accident: non-compliant, accepting help, creative engagement and transfiguration. Implications and future research potentials from this study have been discussed.
Disappearance of the body: An interview with Cécile Bourne Farrell
Authors: Al-Ani Jananne 
Published: October 2017

Abstract
In this interview with curator Cécile Bourne Farrell, artist Jananne Al-Ani discusses her aerial films Shadow Sites I (2010) and Shadow Sites II (2011) and the representation of landscape, from the Middle East to the American south-west, in relation to Kitty Hauser’s book Shadow Sites: Photography, Archaeology, & the British Landscape 1927–1955 (2007) a study on the emergence of aerial archaeology and the role of the sun’s movement in materializing latent histories embedded in the landscape. A French translation of the interview first appeared in issue 59 of the journal Multitudes.
Part 5
Authors: Davis Christine , Lyall Scott , Patton Andy , Haladyn Julian Jason , Leslie Esther , Smith Elizabeth A. T. , Kassay Jacob 
Published: October 2017

Abstract
Entries: Qualified Intensity, Notebooks, Coal Tar, Accidents, Chemical Reciprocal Action, Colour Issues, Makeup, Delivery, Use, Smart Paint?. Includes text by Christine Davis, Scott Lyall, Andy Patton, Julian Jason Haladyn, Esther Leslie, Elizabeth A. T. Smith, Jacob Kassay. Artworks by Andy Patton, Shirley Wiitasalo, F.F. Runge, Helen Frankenthaler, Jacob Kassay
Part 2
Authors: Stengers Isabelle , Smith Tracy K. , Davis Christine 
Published: October 2017

Abstract
Entries: An Eternal Object, Value, Infection, A Confidence of Two, Endurance, Awareness, Experience. Includes text by Isabelle Stengers from Thinking with Whitehead, Christine Davis and Scott Lyall. Artworks by Wael Shawky, Paul P., Christine Davis, Adrian Piper, Terry Adkins, Chris Curreri. Poem by Tracy K. Smith
Part 6
Authors: Davis Christine , Lyall Scott , P. Paul , Balfour Ian , Stengers Isabelle 
Published: October 2017

Abstract
Entries: Contemporaries, Saturation, Noir, Settlements, Seeds, Trees, Audio Cryptograms, Includes text by Christine Davis, Scott Lyall, Paul P., Ian Balfour, Isabelle Stengers. Artworks by Jack Kath, Fiona Annis, Silke Otto-Knapp, Stephen Andrews, Mario Doucette, Nadia Myre, Charles Gaines, Blake Rayne, Charles E.
Burchfield, Nancy Weekly
Poem by Eleni Sikelianos