bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Stable Angina with a New Fixed-Dose Combination of Ivabradine and Metoprolol: Effectiveness and Tolerability in Routine Clinical Practice
Authors: Divchev Dimitar , Stöckl Georg ,   On behalf of the study investigators
Published: November 2017

Abstract
Introduction
In this prospective, multicenter, observational cohort study, the effectiveness and tolerability of the first fixed-dose combination (FDC) formulation of the selective heart rate reducing agent ivabradine and the beta-blocker metoprolol was evaluated in stable angina pectoris (AP) patients in a clinical practice setting.

Methods
Stable AP outpatients received a FDC of ivabradine and metoprolol (b.i.d.) for 4 months, in addition to cardiovascular standard therapy. Resting heart rate (HR), number of angina attacks, short-acting nitrate consumption, severity of symptoms (assessed by patient judgment and documented by CCS score) and tolerability were documented. Medication adherence was assessed by a modified four-item Morisky questionnaire. Descriptive statistics were performed on all data.

Results
A total of 747 stable AP patients (mean age, 66.4 years, 62% male, 50% and 31% with previous PCI and myocardial infarction, respectively) were included. Apart from ivabradine and beta-blockers as free combination, most frequently used concomitant standard medications at baseline were aspirin (68%), statins (71%), ACEI/AT1-blockers (76%), diuretics (35%), and calcium antagonists (15%). Highly prevalent comorbidities were hypertension (86%), hyperlipidemia (65%), and diabetes (35%). After 4 months, switch to treatment with the FDC was associated with a significant reduction in mean HR by 10 bpm. Proportion of patients with ≥ 1 angina attacks/week decreased from 38 to 7%. Patients in CCS class 1 increased (25 to 63%), while they decreased in CCS class 3 (19 to 5%). Medication adherence was also significantly improved (p < 0.001 for all changes from baseline). Mostly mild adverse events were documented in 5.4% of patients.

Conclusions
In these stable AP patients in a real-life setting, treatment with a FDC of ivabradine and metoprolol was associated with reduced HR and angina symptoms, while exercise capacity (CCS score) was improved. These effects may be mainly mediated by the increased medication adherence of patients observed with use of the FDC formulation.

Funding
Servier

Trial registration number
ISRCTN51906157
Electrophysiological Investigations in Orthostatic Myoclonus: Preliminary Findings
Authors: Gunduz Aysegul , Tutuncu Melih , Zeydan Burcu , Apaydin Hulya , Kiziltan Gunes , Ertan Sibel , Kiziltan Meral E. 
Published: November 2017

AbstractWe report the clinical and electrophysiological findings in seven patients with orthostatic myoclonus (OM) associated with gait initiation failure and falls. OM is one of the causes of unsteadiness of stance and gait, and it may develop as a symptom of neurodegenerative disorders. Both positive myoclonic bursts and negative myoclonus may be seen in electrophysiological recordings, and electrophysiological analysis suggests a subcortical origin for OM.
Wave boundary layers in a stratified fluid
Authors: Reznik G. M. 
Published: November 2017

We study so-called wave boundary layers (BLs) arising in a stably stratified fluid at large times. The BL is a narrow domain near the surface and/or bottom of the fluid; with increasing time, gradients of buoyancy and horizontal velocity in the BL grow sharply and the BL thickness tends to zero. The non-stationary BL can arise both as a result of linear evolution of the initial perturbation and under the action of an external force (tangential stress exerted on the fluid surface in our case). We analyse both the variants and find that the ‘forced’ BLs are much more intense than the ‘free’ ones. In the ‘free’ BLs all fields are bounded and the gradients of buoyancy and horizontal velocity grow linearly in time, whereas in the ‘forced’ BL only the vertical velocity is bounded and the buoyancy and horizontal velocity grow linearly in time. As to the gradients in the ‘forced’ BL, the vertical velocity gradient grows in time linearly and the gradients of buoyancy and horizontal velocity grow quadratically. In both of the cases we determine exact solutions in the form of expansions in the vertical wave modes and find asymptotic solutions valid at large times. The comparison between them shows that the asymptotic solutions approximate the exact ones fairly well even for moderate times.
On the dynamics of starting plumes
Authors: Bhamidipati N. , Woods Andrew W. 
Published: November 2017

We explore the dynamics of starting plumes by analysis of a series of new small-scale laboratory experiments combined with a theoretical model for mass, momentum, and buoyancy conservation. We find that the head of the plume ascends with a speed which is approximately 0.6 times the characteristic speed of the fluid in the following steady plume, in accord with Turner (J. Fluid Mech., vol. 13 (03), 1962, pp. 356–368), and so the fluid released from the source eventually catches the head of the flow. On reaching the top of the plume it recirculates and mixes in the plume head. We estimate that approximately $0.61\pm 0.04$ of the total buoyancy released from the source accumulates in the plume head, with the remainder in the following steady plume. Using measurements of the volume of the head, we estimate that a fraction $0.16\pm 0.08$ of the volume of the head is entrained directly from the ambient, with the remainder of the fluid in the head being supplied by the following steady plume. These results imply that the buoyancy force exerted on the plume head plus the momentum flux supplied by the following plume exceeds the rate of change of momentum of the plume head even including the added mass of the plume head. We propose that the difference is associated with a drag force resulting from the displacement of ambient fluid around the plume head. Using our experimental data, we estimate that the drag coefficient $C_{d}$ has a value $4.2\pm 1.4$, with the range in values associated with the uncertainty in our estimate of entrainment of fluid directly into the plume head. As a test, the proposed model is shown to provide a reasonable description of a starting plume rising through a stratified environment in the region below the maximum height of rise of the associated steady plume, although, above this point, the shape of the plume head changes and the model breaks down.
The relationship between networking behavior and promotability: The moderating effect of political skill
Authors: Huang Yin-Mei 
Published: November 2017

AbstractNetworking behaviors toward career and community domains assist individuals in doing their jobs better and advancing their careers. However, few studies investigate and identify how these different types of networking behaviors lead to supervisory promotability evaluations. The current study argues that career- and community-based networking behaviors interact with political skill on promotability. This study surveyed and collected data from 160 financial employees and 103 supervisors working at branches of a large bank in Taiwan. Career-based networking behaviors, particularly maintaining contacts and engaging in professional activities, were found to be positively related to promotability, and political skill strengthened the relationship between community-based networking behaviors and promotability. The implications of these findings are discussed in terms of networking behaviors, political skill, and promotability.
Spectral-Line Observations Using a Phased Array Feed on the Parkes Telescope
Authors: Reynolds T.N. , Staveley-Smith L. , Rhee J. , Westmeier T. , Chippendale A. P. , Deng X. , Ekers R. D. , Kramer M. 
Published: November 2017

AbstractWe present first results from pilot observations using a phased array feed (PAF) mounted on the Parkes 64-m radio telescope. The observations presented here cover a frequency range from 1 150 to 1 480 MHz and are used to show the ability of PAFs to suppress standing wave problems by a factor of ~10, which afflict normal feeds. We also compare our results with previous HIPASS observations and with previous H i images of the Large Magellanic Cloud. Drift scan observations of the GAMA G23 field resulted in direct H i detections at z = 0.0043 and z = 0.0055 of HIPASS galaxies J2242-30 and J2309-30. Our new measurements generally agree with archival data in spectral shape and flux density, with small differences being due to differing beam patterns. We also detect signal in the stacked H i data of 1 094 individually undetected galaxies in the GAMA G23 field in the redshift range 0.05 ⩽ z ⩽ 0.075. Finally, we use the low standing wave ripple and wide bandwidth of the PAF to set a 3σ upper limit to any positronium recombination line emission from the Galactic Centre of <0.09 K, corresponding to a recombination rate of <3.0 × 1045 s−1.
Effect of fibre additions to flatbread flour mixes on glucose kinetics: a randomised controlled trial
Authors: Boers Hanny M. , van Dijk Theo H. , Hiemstra Harry , Hoogenraad Anne-Roos , Mela David J. , Peters Harry P. F. , Vonk Roel J. , Priebe Marion G. 
Published: November 2017

AbstractWe previously found that guar gum (GG) and chickpea flour (CPF) added to flatbread wheat flour lowered postprandial blood glucose (PPG) and insulin responses dose dependently. However, rates of glucose influx cannot be determined from PPG, which integrates rates of influx, tissue disposal and hepatic glucose production. The objective was to quantify rates of glucose influx and related fluxes as contributors to changes in PPG with GG and CPF additions to wheat-based flatbreads. In a randomised cross-over design, twelve healthy males consumed each of three different13C-enriched meals: control flatbreads (C), or C incorporating 15 % CPF with either 2 % (GG2) or 4 % (GG4) GG. A dual isotope technique was used to determine the time to reach 50 % absorption of exogenous glucose (T50 %abs, primary objective), rate of appearance of exogenous glucose (RaE), rate of appearance of total glucose (RaT), endogenous glucose production (EGP) and rate of disappearance of total glucose (RdT). Additional exploratory outcomes included PPG, insulin, glucose-dependent insulinotropic peptide and glucagon-like peptide 1, which were additionally measured over 4 h. Compared with C, GG2 and GG4 had no significant effect onT50 %abs. However, GG4 significantly reduced 4-h AUC values for RaE, RaT, RdT and EGP, by 11, 14, 14 and 64 %, respectively, whereas GG2 showed minor effects. Effect sizes over 2 and 4 h were similar except for significantly greater reduction in EGP for GG4 at 2 h. In conclusion, a soluble fibre mix added to flatbreads only slightly reduced rates of glucose influx, but more substantially affected rates of postprandial disposal and hepatic glucose production.
Perinatal maternal high-fat diet induces early obesity and sex-specific alterations of the endocannabinoid system in white and brown adipose tissue of weanling rat offspring
Authors: Almeida Mariana M. , Dias-Rocha Camilla P. , Souza André S. , Muros Mariana F. , Mendonca Leonardo S. , Pazos-Moura Carmen C. , Trevenzoli Isis H. 
Published: November 2017

AbstractPerinatal maternal high-fat (HF) diet programmes offspring obesity. Obesity is associated with overactivation of the endocannabinoid system (ECS) in adult subjects, but the role of the ECS in the developmental origins of obesity is mostly unknown. The ECS consists of endocannabinoids, cannabinoid receptors (cannabinoid type-1 receptor (CB1) and cannabinoid type-2 receptor (CB2)) and metabolising enzymes. We hypothesised that perinatal maternal HF diet would alter the ECS in a sex-dependent manner in white and brown adipose tissue of rat offspring at weaning in parallel to obesity development. Female rats received standard diet (9 % energy content from fat) or HF diet (29 % energy content from fat) before mating, during pregnancy and lactation. At weaning, male and female offspring were killed for tissue harvest. Maternal HF diet induced early obesity, white adipocyte hypertrophy and increased lipid accumulation in brown adipose tissue associated with sex-specific changes of the ECS’s components in weanling rats. In male pups, maternal HF diet decreased CB1 and CB2 protein in subcutaneous adipose tissue. In female pups, maternal HF diet increased visceral and decreased subcutaneous CB1. In brown adipose tissue, maternal HF diet increased CB1 regardless of pup sex. In addition, maternal HF diet differentially changed oestrogen receptor across the adipose depots in male and female pups. The ECS and oestrogen signalling play an important role in lipogenesis, adipogenesis and thermogenesis, and we observed early changes in their targets in adipose depots of the offspring. The present findings provide insights into the involvement of the ECS in the developmental origins of metabolic disease induced by inadequate maternal nutrition in early life.
How to Gamble in Greek: The Meaning of Kubeia
Authors: Kidd Stephen E. 
Published: November 2017

AbstractKubeia and its congeners are often translated as ‘playing dice’ or ‘dicing’ because kuboi are ‘dice’. But sometimes kubeia has nothing to do with ‘dice’ (kuboi) at all, and so ought often to be translated simply as ‘gambling’. Pollux explains the nature of the word clearly in book 7, and his position is supported by earlier authors such as Theopompus, Diphilus, Isocrates, Xenophon and Aeschines. Not only is it possible to ‘gamble’ (kubeuein) with knucklebones (astragaloi) as well as cubic dice (kuboi), it is also possible to ‘gamble’ (kubeuein) by folding leather straps, by spinning coins and by guessing about small objects hidden in the hand; it is even possible to ‘gamble’ (kubeuein) during a cock-fight. The mistaken belief that the word means ‘dicing’ has affected not only centuries of translations and interpretations, but also the editing of texts since at least the early 19th century, as is shown regarding a crux in Aeschines’ Against Timarchus.
Gadfly or Spur? The Meaning of ΜΎΩΨ in Plato’s Apology of Socrates
Authors: Marshall Laura A. 
Published: November 2017

AbstractThe standard translation of μύΩΨ in Plato’s Apology of Socrates 30e is ‘gadfly’. However, this word was generally translated as ‘spur’ until the 1800s. This article re-evaluates the scholarship that led to the ‘gadfly’ translation and argues that the ‘spur’ translation is correct based on the use elsewhere in Greek literature of μύΩΨ and other significant words in the passage.
Evaluating the conservation status of the Black-fronted FrancolinPternistis atrifrons
Authors: GEDEON KAI , RÖDDER DENNIS , ZEWDIE CHEMERE , TÖPFER TILL 
Published: November 2017

SummaryThe occurrence of the Black-fronted FrancolinPternistis atrifronsis restricted to a tiny area in southern Ethiopia. Based on field studies from 2012 to 2014, we modelled the range and estimated the population size of the species in order to evaluate its current conservation status. Annual mean temperature (relatively low) and precipitation (relatively high) proved to be key factors for the probability of its occurrence. The modelled range is 1,286 km2(“extent of occurrence” according to the IUCN Red List criteria). However, only about one third of the modelled range is actually populated by the Black-fronted Francolin. This area, around 385 km2, corresponds to the IUCN’s “area of occupancy”. The total population size is estimated at 1,100 to 2,100 mature individuals. Thus, we conclude that the species should be classified as Endangered, criteria: A2c+B1ab(i,iii,v) + B2ab(i,iii,v); population trend: decreasing. This means that the Black-fronted Francolin is one of Africa’s most endangered galliforms. Major threats are range and habitat losses due to agricultural expansion, grazing pressure, commercial firewood and timber exploitation, and hunting. Furthermore, expected climate changes in south-east Ethiopia (higher temperatures, less precipitation) could further exacerbate these threats. We propose urgent conservation actions, including the extension of the currently projected Borana National Park.
An unusual course of anti-Ro antibody-mediated fetal complete heart block
Authors: Renaud Claudia , Jaeggi Edgar , Thakur Varsha 
Published: November 2017

AbstractFetal hydrops is a serious complication of immune-mediated congenital complete atrioventricular block. We present the case of a fetus with severe hydrops and profound bradycardia and an unusual favourable outcome. This case enhances the importance of considering the contribution of ventricular ectopic beats to the cardiac output when counselling and predicting outcome of complete heart block.
Eating occasions and the contribution of foods to sodium and potassium intakes in adults
Authors: Dickinson Kacie M , Chan Lily , Moores Carly J , Miller Jacqueline , Thomas Jolene , Yaxley Alison , Jackson Kathryn , Mehta Kaye , Matwiejczyk Louisa , Wray Amanda , Miller Michelle 
Published: November 2017

AbstractObjectiveTo examine dietary Na and K intake at eating occasions in Australian adults and identify the contribution of major food sources to Na and K at different eating occasions.DesignSecondary analysis of 24 h recall diet data from the Australian Health Survey (2011–2013).SettingNationally representative survey in Australia.SubjectsMale and female Australians aged 18–84 years (n7818).ResultsDinner contributed the greatest proportion to total daily Na intake (33 %) and K intake (35 %). Na density was highest at lunch (380 mg/MJ) and K density highest at between-meal time eating occasions (401 mg/MJ). Between-meal time eating occasions provided 20 % of daily Na intake and 26 % of daily K intake. The major food group sources of Na were different at meal times (breads and mixed dishes) compared with between-meal times (cakes, muffins, scones, cake-type desserts). The top food group sources of K at meal times were potatoes and unprocessed meat products and dishes.ConclusionsFoods which contributed to Na and K intake differed according to eating occasion. Major food sources of Na were bread and processed foods. Major food sources of K were potatoes and meat products and dishes. Public health messages that emphasise meal-based advice and diet patterns high in vegetables, fruits and unprocessed foods may also aid reduction in dietary Na intake and increase in dietary K intake.
Regulation of Inter-Provincial Establishment in China: Learning from Europe?
Authors: SHEN GUANG 
Published: November 2017

AbstractWith a multilevel governance structure, China and the EU both face the task of preventing lower level political entities from impeding capital mobility. In China, licensing barriers, as the main protectionist measure, are sometimes created by local authorities, leading to restrictions on inter-provincial establishment of companies. Moreover, whether or not to create such barriers depends on various factors. In the EU, a major effort has been undertaken to facilitate cross-border establishment and any remaining barriers mainly arise from national regulatory autonomy in some areas. In terms of further facilitating company mobility, while the strong judicial mechanism in the EU has tackled some of the remaining barriers, China's weak administrative and judicial systems seem unable to prevent the creation of licensing barriers. This paper argues that precise rules defined by the legislative authority offer a better prospect of regulatory effectiveness for China whose administrative capacities are weak and courts are not independent. More specifically, legislative decision making in the setting of inter-provincial establishment should be taken at the central level. Moreover, national legislators should precisely and clearly prescribe which authorities are empowered to control inter-provincial establishment, and under what conditions.
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
Authors: Yu Mei , Chen Yuhong , Zeng Hu , Zheng Yongwei , Fu Guoping , Zhu Wen , Broeckel Ulrich , Aggarwal Praful , Turner Amy , Neale Geoffrey , Guy Cliff , Zhu Nan , Chi Hongbo , Wen Renren , Wang Demin 
Published: November 2017

AbstractThe precise molecular mechanism underlying the regulation of early B cell lymphopoiesis is unclear. The PLCγ signaling pathway is critical for antigen receptor-mediated lymphocyte activation, but its function in cytokine signaling is unknown. Here we show that PLCγ1/PLCγ2 double deficiency in mice blocks early B cell development at the pre-pro-B cell stage and renders B cell progenitors unresponsive to IL-7. PLCγ pathway inhibition blocks IL-7-induced activation of mTOR, but not Stat5. The PLCγ pathway activates mTOR through the DAG/PKC signaling branch, independent of the conventional Akt/TSC/Rheb signaling axis. Inhibition of PLCγ/PKC-induced mTOR activation impairs IL-7-mediated B cell development. PLCγ1/PLCγ2 double-deficient B cell progenitors have reduced expression of genes related to B cell lineage, IL-7 signaling, and cell cycle. Thus, IL-7 receptor controls early B lymphopoiesis through activation of mTOR via PLCγ/DAG/PKC signaling, not via Akt/Rheb signaling.
The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding
Authors: Tarbouriech Nicolas , Ducournau Corinne , Hutin Stephanie , Mas Philippe J. , Man Petr , Forest Eric , Hart Darren J. , Peyrefitte Christophe N. , Burmeister Wim P. , Iseni Frédéric 
Published: November 2017

AbstractVaccinia virus (VACV), the prototype member of thePoxviridae, replicates in the cytoplasm of an infected cell. The catalytic subunit of the DNA polymerase E9 binds the heterodimeric processivity factor A20/D4 to form the functional polymerase holoenzyme. Here we present the crystal structure of full-length E9 at 2.7 Å resolution that permits identification of important poxvirus-specific structural insertions. One insertion in the palm domain interacts with C-terminal residues of A20 and thus serves as the processivity factor-binding site. This is in strong contrast to all other family B polymerases that bind their co-factors at the C terminus of the thumb domain. The VACV E9 structure also permits rationalization of polymerase inhibitor resistance mutations when compared with the closely related eukaryotic polymerase delta–DNA complex.
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells
Authors: Sintes Jordi , Gentile Maurizio , Zhang Shuling , Garcia-Carmona Yolanda , Magri Giuliana , Cassis Linda , Segura-Garzón Daniel , Ciociola Alessandra , Grasset Emilie K. , Bascones Sabrina , Comerma Laura , Pybus Marc , Lligé David , Puga Irene , Gutzeit Cindy , He Bing , DuBois Wendy , Crespo Marta , Pascual Julio , Mensa Anna , Aróstegui Juan Ignacio , Juan Manel , Yagüe Jordi , Serrano Sergi , Lloreta Josep , Meffre Eric , Hahne Michael , Cunningham-Rundles Charlotte , Mock Beverly A. , Cerutti Andrea 
Published: November 2017

AbstractMechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic reconfiguration of marginal zone (MZ) B cells, a pre-activated lymphocyte subset that mounts antibody responses to T-cell-independent antigens through a Toll-like receptor (TLR)-amplified pathway involving transmembrane activator and CAML interactor (TACI). This receptor interacts with mTOR via the TLR adapter MyD88. The resulting mTOR activation instigates MZ B-cell proliferation, immunoglobulin G (IgG) class switching, and plasmablast differentiation through a rapamycin-sensitive pathway that integrates metabolic and antibody-inducing transcription programs, including NF-κB. Disruption of TACI–mTOR interaction by rapamycin, truncation of the MyD88-binding domain of TACI, or B-cell-conditional mTOR deficiency interrupts TACI signaling via NF-κB and cooperation with TLRs, thereby hampering IgG production to T-cell-independent antigens but not B-cell survival. Thus, mTOR drives innate-like antibody responses by linking proximal TACI signaling events with distal immunometabolic transcription programs.