bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of Abandonment of Therapy in Pediatric Patients with Cancer in Guatemala
Authors: Alvarez Elysia , Seppa Midori , Messacar Kevin , Kurap John , Sweet-Cordero E. Alejandro , Rivas Silvia , Bustamante Marisol , Fuentes Lucia , Antillón-Klussmann Federico , Valverde Patricia , Castellanos Mauricio , Howard Scott C. , Efron Bradley , Luna-Fineman Sandra 
Published: July 2016

Abstract 59 Background: Abandonment of therapy is a major cause of therapeutic failure in the treatment of childhood cancer in Low and Middle Income Countries (LMIC). This study examines factors associated with increased risk of therapy abandonment in Guatemalan children with cancer and the rates of therapy abandonment before and after implementation of a multidisciplinary psychosocial intervention program. Methods: A retrospective population-based study was performed to identify risk factors for abandonment of therapy in Guatemalan children, ages 0-18, with cancer who were seen at UNOP from 2001-2008. Patient data was collected from the Pediatric Oncology Networked Database (POND4Kids). Abandonment was defined as a lapse of 4 weeks in planned treatment or failure to begin treatment for a potentially curable cancer. Cox proportional hazards analysis identified the effect of age, sex, year of diagnosis, distance travelled to UNOP, ethnicity, and principal diagnosis on abandonment of therapy. Kaplan Meier analysis was used to evaluate survival. Results: A retrospective analysis of 1,789 charts was performed and 367 patients abandoned therapy. The rate of abandonment decreased from 27% in 2001 to 7% in 2008 following a multidisciplinary psychosocial intervention program. Greater distance to UNOP (p = 0.00), younger age (p = 0.02) and earlier year of diagnosis (p = 0.00) were associated with increased risk of abandonment. Abandonment of therapy correlated with decreased survival. The cumulative survival at 8.3 years was 0.57 ± 0.02 (survival±SE) for those who completed therapy vs 0.06 ± 0.02 for those who abandoned and refused therapy (p=0.000) in an abandonment sensitive analysis. Conclusion: This study identified distance, age, and year of diagnosis as risk factors for abandonment of therapy for pediatric cancer in Guatemala. This study highlights risk factors for abandonment of therapy and the role of targeted interventions in altering rates of abandonment that could be replicated in other LMIC countries. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST: No COIs from the authors.
Assessment of Adequacy of Pain Management and Analgesic Use in Patients With Advanced Cancer Using the Brief Pain Inventory and Pain Management Index Calculation
Authors: Singh Harminder , Banipal Raja Paramjeet Singh , Singh Baltej 
Published: July 2016

Purpose The objective of this cross-sectional, noninterventional, 6-month observational study was to assess the adequacy of pain management in patients with cancer admitted to the Oncology Department of Guru Gobind Singh Medical College in Faridkot, India. Methods and Materials A total of 348 patients with cancer were recruited for evaluation of the prevalence of inadequate cancer pain management using the Brief Pain Inventory Pain Management Index. Results The current study included 127 males (36.5%) and 221 females (63.5%). The most prevalent cancer type was genitourinary; 268 patients (77%) had inadequately managed pain. A significant correlation was observed between poorly managed pain and age groups, analgesic used, and body mass index. Conclusion Our observation of inadequate pain management among 77% of patients indicates that pain management was insufficient in three quarters of the patients in this study. Accumulating data regarding the inadequacy of cancer pain management is crucial to improve symptom management. Better management of pain not only alleviates pain symptoms but also increases the quality of life for patients with cancer.
Age components of queen retinue workers in honeybee colony (Apis mellifera)
Authors: Yi Yao , Li You , Zeng Zhijiang 
Published: July 2016

It’s known that elaborate age is closely associated with polyethism in honeybee colonies, and the circle composed of queen retinue workers is a usual phenomenon in honeybee colonies. In this study, we showed that the age-bracket of retinue workers is 2-23d, but mainly 6-18d by marking newly hatched workers in two colonies.
Real-Time Quantification of Amino Acids in the Exhalome by Secondary Electrospray Ionization–Mass Spectrometry: A Proof-of-Principle Study
Authors: García-Gómez Diego , Gaisl Thomas , Bregy Lukas , Cremonesi Alessio , Sinues Pablo Martinez-Lozano , Kohler Malcolm , Zenobi Renato 
Published: July 2016

Abstract

BACKGROUND
Amino acids are frequently determined in clinical chemistry. However, current analysis methods are time-consuming, invasive, and suffer from artifacts during sampling, sample handling, and sample preparation. We hypothesized in this proof-of-principle study that plasma concentrations of amino acids can be estimated by measuring their concentrations in exhaled breath. A novel breath analysis technique described here allows such measurements to be carried out in real-time and noninvasively, which should facilitate efficient diagnostics and give insights into human physiology.

METHODS
The amino acid profiles in 37 individuals were determined by ion-exchange HPLC in blood plasma and simultaneously in breath by secondary electrospray ionization coupled to high-resolution mass spectrometry. Participants were split into training and test sets to validate the analytical accuracy. Longitudinal profiles in 3 individuals were additionally obtained over a 12-h period.

RESULTS
Concentrations of 8 slightly volatile amino acids (A, V, I, G, P, K, F, Orn) could be determined in exhaled breath with a CV of &lt;10%. Exhalome validation studies yielded high accuracies for each of these amino acids, on average only 3% less compared to plasma concentrations (95% CI ±13%). Higher variations were found only for amino acids with a low plasma concentration.

CONCLUSIONS
This study demonstrates for the first time that amino acids can be quantified in the human breath and that their concentrations correlate with plasma concentrations. Although this noninvasive technique needs further investigation, exhalome analysis may provide significant benefits over traditional, offline analytical methods.
Performing freedom: The role of music-making in creating a community in asylum seeker detention centres
Authors: Weston Donna , Lenette Caroline 
Published: July 2016

Abstract
This article puts forward a reimagining of the concept of community in an immigration detention centre that emerged from the creation of cultural and performative spaces. It is argued that conceptualizing immigration detention centres as accidental communities can contribute to an understanding of the impact of participatory music-making activities in these spaces on the well-being of detainees. The research is based on the analysis of music facilitators’ narratives of their experience in an Australian detention centre in 2012. Accidental communities are defined as those in which people are connected not through common culture or region, but who have been brought together by circumstance, and whose shared experience therefore forms the basis of their relationships within the community. It is proposed that participation in music-making activities in an accidental community informs a cultural space on the basis of expression of that experience rather than cross-cultural sharing and that the resultant politics of inclusion have a positive impact on the well-being of the detainees.
Hospitality in multicultural choral singing
Authors: Balsnes Anne Haugland 
Published: July 2016

Abstract
According to Higgins, hospitality is the central characteristic of community music. This article discusses how hospitality is expressed in so-called ‘multicultural choirs’ – which exist in several Norwegian cities – and the impact, if any, such hospitable musical and social environments have on members with a refugee background. Based on a case study of KIA Multicultural Gospel Choir in Kristiansand, Norway, using collection techniques such as participant observation and qualitative research interviews, various aspects of this specific form of community music are discussed. The analysis is illuminated by theoretical perspectives drawn from the fields of community music, music therapy, social psychology and the social sciences. The results show that the choral practice contributes to community, empowerment and respect, integration and meaning in the refugees’ lives. The purpose of the article is to deepen insights into a practice model such as is found in these multicultural choirs. The results have implications for social welfare politics and for the community music and music education fields.
ACTN3 R577X Gene Variant Is Associated With Muscle-Related Phenotypes in Elite Chinese Sprint/Power Athletes
Authors: Yang Ruoyu , Shen Xunzhang , Wang Yubin , Voisin Sarah , Cai Guang , Fu Yongnan , Xu Wangyu , Eynon Nir , Bishop David J. , Yan Xu 
Published: July 2016

Abstract
Yang, R, Shen, X, Wang, Y, Voisin, S, Cai, G, Fu, Y, Xu, W, Eynon, N, Bishop, DJ, and Yan, X. ACTN3 R577X gene variant is associated with muscle-related phenotypes in elite Chinese sprint/power athletes. J Strength Cond Res 31(4): 1107–1115, 2017—The ACTN3 R577X polymorphism (rs1815739) has been shown to influence athletic performance. The aim of this study was to investigate the prevalence of this polymorphism in elite Chinese track and field athletes, and to explore its effects on athletes' level of competition and lower-extremity power. We compared the ACTN3 R577X genotypes and allele frequencies in 59 elite sprint/power athletes, 44 elite endurance athletes, and 50 healthy controls from Chinese Han origin. We then subcategorized the athletes into international level and national level and investigated the effects of ACTN3 genotype on lower-extremity power. Genotype distribution of the sprint/power athletes was significantly different from endurance athletes (p = 0.001) and controls (p < 0.001). The frequency of the RR genotype was significantly higher in international-level than that in the national-level sprint/power athletes (p = 0.004), with no international-level sprint/power athletes with XX genotype. The best standing long jump and standing vertical jump results of sprint/power athletes were better in the RR than those in the RX + XX genotypes (p = 0.004 and p = 0.001, respectively). In conclusion, the ACTN3 R577X polymorphism influences the level of competition and lower-extremity power of elite Chinese sprint/power athletes. Including relevant phenotypes such as muscle performance in future studies is important to further understand the effects of gene variants on elite athletic performance.
The Suspension Inverted Row
Authors: Ronai Peter , Scibek Eric 
Published: July 2016

ABSTRACT
THE SUSPENSION-INVERTED ROW IS A MULTIJOINT UPPER-BODY EXERCISE THAT CAN INCREASE SHOULDER GIRDLE AND LUMBAR SPINE STABILITY, UPPER-BODY STRENGTH, AND PERFORMANCE OF ACTIVITES REQUIRING HIGH LEVELS OF STRENGTH. IT IS A VARIATION OF THE INVERTED ROW WITH A BAR AND IT CAN BE PROGRESSED, REGRESSED, AND PERFORMED THROUGHOUT A TRAINING YEAR. THIS ARTICLE PROVIDES A DETAILED DESCRIPTION AND FIGURES OF THE PROPER EXERCISE TECHNIQUE FOR A SUSPENSION-INVERTED ROW. FOR A VIDEO ABSTRACT OF THIS ARTICLE, SEE SUPPLEMENTAL DIGITAL CONTENT 1 (SEE VIDEO, http://links.lww.com/SCJ/A191).
Progressions of Isometric Core Training
Authors: Mendrin Natasha , Lynn Scott K. , Griffith-Merritt Halecia K. , Noffal Guillermo J. 
Published: July 2016

ABSTRACT
WITH THE GROWTH IN POPULARITY OF CORE TRAINING, IT IS IMPORTANT THAT THERE IS A CLEAR UNDERSTANDING OF HOW TO BEST TAILOR THESE EXERCISES TO SAFELY MEET THE NEEDS OF DIFFERENT INDIVIDUALS. EXTENSIVE RESEARCH HAS SHOWN THAT TRAINING THE CORE MUSCLES ISOMETRICALLY, THAT IS WITHOUT BENDING THE SPINE, IS SAFE AND MAY HELP REDUCE THE INCIDENCE OF BACK INJURY. EXERCISE PROFESSIONALS MUST HAVE THE ABILITY TO MODIFY ISOMETRIC CORE EXERCISES AND ALTER THEIR DIFFICULTY TO ENSURE THAT THEY PROVIDE A SAFE AND APPROPRIATE CHALLENGE FOR INDIVIDUALS OF VARYING FITNESS LEVELS AND TRAINING GOALS. THEREFORE, THIS ARTICLE SUMMARIZES THE CURRENT RESEARCH THAT OUTLINES THE POTENTIAL NEGATIVE CONSEQUENCES OF CONSTANTLY BENDING OR MOVING THROUGH THE SPINE. THIS PROVIDES THE RATIONALE FOR TRAINING THE CORE ISOMETRICALLY TO AVOID REPLICATING THESE KNOWN MECHANISMS OF INJURY DURING EXERCISE. EXAMPLES OF ISOMETRIC CORE EXERCISES OF VARYING DIFFICULTY ARE ALSO PROVIDED, AS WELL AS A MODEL OUTLINING HOW TO IMPLEMENT THESE PROGRESSIONS TO SAFELY MEET THE NEEDS OF ANY INDIVIDUAL IN A GENERAL FITNESS POPULATION.
Studi Perbedaan Keefektifan Pembelajaran LC-5E dan CIRC Terhadap Kemampuan Pemecahan Masalah Matematika
Authors: Sulastri E. , Mariani Scolastika , Mashuri Mashuri 
Published: July 2016

<p>membandingkan keefektifan model pembelajaran kooperatif tipe LC-5E (<em>Learning Cycle 5E</em>) dan tipe CIRC(<em>Cooperative Integrated Reading and Compos</em><em>i</em><em>tion</em>) terhadap kemampuan pemecahan masalah matematika peserta didik. Populasi penelitian adalah peserta didik kelas X SMA Negeri 2 Ungaran. Sampel diambil secara <em>cluster random sampling</em>. Data akhir mengenai kemampuan pemecahan masalah diambil menggunakan metode tes<em>. </em>Teknik analisis data menggunakan uji proporsi, uji Anava dan uji lanjut LSD. Hasil penelitian menunjukkan kelas yang dikenai perlakuan pembelajaran LC-5Edan CIRCmencapai ketuntasan belajar. Dari uji Anava diketahui bahwa ada perbedaan rata-rata yang signifikan. Selanjutnya dilakukan uji lanjut LSDmenunjukkan Kelompok Eksperimen 1 paling baik. Simpulan dari penelitian ini adalah model pembelajaran LC-5Elebih efektif dibandingkan tipe CIRC terhadap kemampuan pemecahan masalah peserta didik. Saran yang dapat direkomendasikan adalah pembelajaran LC-5E dapat digunakan sebagai alternatif dalam mengembangkan kemampuan pemecahan masalah peserta didik.</p><p> </p><p><em>The purpose of this research was to</em><em>comparethe effectiveness of cooperative learning models type LC-5E (Learning Cycle 5E) and type CIRC (Cooperative Integrated Reading and Composition) toward students’ mathematic problem solving ability. The population of this research was students grade X of SMA Negeri 2 Ungaran.The samples were taken by cluster random sampling. The final data about students’ problem solving ability were taken used test method. Data were analysed used propotion test, ANOVA test, and LSD test. The result shown that classes that given LC-5E and CIRC learning models achieved mastery learning. From ANOVA test known that the averages are different significantly.From LSD test is known that the experiment group was the best. The conclusions from this research are LC-5E is more effective than CIRC learning model toward students’ problem solving ability. The suggestion is LC-5E model can be used as an alternative to develope stundents’ problem solving ability.</em></p>
Meningkatkan Komunikasi Matematis Peserta Didik Melalui “Disco LeMPer” berbantuan Software GeoGebra
Authors: Jurotun Jurotun 
Published: July 2016

<p align="justify">Peserta didik belum menguasai kemampuan komunikasi matematika, baik kemampuan matematika lisan maupun kemampuan matematika secara tertulis. Peserta didik sulit membedakan penggunaan simbol dan lambang matematika, mengubah masalah nyata ke dalam bahasa matematika, serta mentransfer bentuk matematika ke dalam masalah nyata, peserta didik jarang mengajukan pertanyaan ataupun memberikan pendapatnya dalam proses pembelajaran matematika. Penelitian ini bertujuan untuk meningkatkan komunikasi matematis melalui “Disco LeMPer” berbantuan Software GeoGebra. Penelitian ini adalah jenis penelitian tindakan kelas dengan Jenis penelitian ini adalah penelitian tindakan kelas yang terdiri dari silkus 1 dan siklus 2. Penelitian Tindakan Kelas ini dilaksanakan di kelas XI MIA3 SMA Negeri 1 Dempet. Alat pengumpulan data yang digunakan adalah lembar observasi dan tes tertulis. Hasil penelitian diperoleh bahwa terjadi peningkatan komunikasi matematis lisan sebesar 45% pada siklus 1 dan 22% pada siklus 2. Sedangkan untuk komunikasi tertulis terjadi peningkatan sebesar 30% untuk siklus 1 dan 42% untuk siklus 2. Dengan demikian pembelajaran Disco LeMPer berbantuan software GeoGebra dapat meningkatkan komunikasi matematis peserta didik SMA untuk materi irisan kerucut. </p><p align="justify"><em>Learners have not mastered the mathematical communication skills, both verbal and math skills math skills in writing. Learners are difficult to distinguish the use of symbols and mathematical symbol, changing the real problems into mathematical language, as well as the transfer form to the real problems of mathematics, students rarely ask questions or give opinions in the process of learning mathematics. This study aims to improve mathematical communication through "Disco Lemper" aided software GeoGebra.This research is a classroom action research with the type of research is a class action consisting of cycle 1 and cycle 2. Class Action Research was conducted in class XI MIA3 SMA Negeri 1 Dempet. Data collection tools used were observation sheet and a written tes. The results showed that an increase in oral mathematical communication by 45 % in cycle 1 and 22 % in cycle 2. As for written communication an increase of 30 % for the first cycle and 42 % for cycle 2. Thus Disco Lemper aided learning software GeoGebra can improve communication mathematical high school students to the material conic sections. </em></p>
Desain Didaktis Penalaran Matematis untuk Mengatasi Kesulitan Belajar Siswa SMP pada Luas dan Volume Limas
Authors: Sulistiawati Sulistiawati , Suryadi Didi , Fatimah Siti 
Published: July 2016

<p>Penelitian ini dilatarbelakangi oleh rendahnya kemampuan penalaran matematis siswa SMP pada materi geometri. Metode penelitian yang digunakan adalah penelitian desain didaktis (<em>didactial</em> <em>design research</em>). Penelitian diawali dengan studi pendahuluan untuk mendapatkan data kesulitan belajar (<em>learning obstacle</em>) yang dilaksanakan di SMP Negeri 29 Bandung kelas IXE sebanyak 35 orang, SMA Negeri 1 Lembang kelas XI IPA2 sebanyak 41 orang, dan STKIP Siliwangi Bandung mahasiswa semester VI sebanyak 49 orang pada tahun pelajaran 2011/2012 semester genap. Selanjutnya, dikembangkan desain didaktis yang diujicobakan terbatas kepada 30 siswa kelas VIII B SMP Assalam Bandung. Dari uji coba terbatas dilakukan analisis untuk menyusun desain didaktis revisi. Hasil dari penelitian ini diantaranya perangkat pembelajaran yang digunakan pada pembelajaran sebelum menggunakan desain didaktis belum dapat menggali kemampuan penalaran matematis, desain didaktis penalaran matematis yang dikembangkan dapat memperkecil <em>gap</em> yang dihadapi siswa, dan siswa memberikan tanggapan positif terhadap desain didaktis yang dikembangkan.<strong></strong></p><p>The background of this research was the lack of junior high school students’ mathematical reasoning in geometry. This research used Didactical Design Research (DDR) method which started by a preliminary study to 35 students of grade IX E Public Junior High School 29 Bandung, 41 students of grade XI Science Program of Senior High School 1 Lembang, and 49 students of Siliwangi College of Education Bandung in semester VI for academic year 2011/2012. The preliminary study was aimed to explore students’ learning obstacles to develep didactical design. The developed didactical design was implemented to 30 students of grade VII B of Assalam Junior High School Bandung. After this implementation the developed didactical design was revised. The results of this research were the learning tools used by previous teacher have not explored mathematical reasoning yet, the developed didactical design had minimized students’ gaps, and students had positive response about the learning.</p>
Empirical Bayes Estimation of Coalescence Times from Nucleotide Sequence Data
Authors: King Leandra , Wakeley John 
Published: July 2016

AbstractWe demonstrate the advantages of using information at many unlinked loci to better calibrate estimates of the time to the most recent common ancestor (TMRCA) at a given locus. To this end, we apply a simple empirical Bayes method to estimate the TMRCA. This method is both asymptotically optimal, in the sense that the estimator converges to the true value when the number of unlinked loci for which we have information is large, and has the advantage of not making any assumptions about demographic history. The algorithm works as follows: we first split the sample at each locus into inferred left and right clades to obtain many estimates of the TMRCA, which we can average to obtain an initial estimate of the TMRCA. We then use nucleotide sequence data from other unlinked loci to form an empirical distribution that we can use to improve this initial estimate.
Parent-of-Origin-Effect rough endosperm Mutants in Maize
Authors: Bai Fang , Daliberti Mary , Bagadion Alyssa , Xu Miaoyun , Li Yubing , Baier John , Tseung Chi-Wah , Evans Matthew M S , Settles A Mark 
Published: July 2016

Abstract
Parent-of-origin-effect loci have non-Mendelian inheritance in which phenotypes are determined by either the maternal or paternal allele alone. In angiosperms, parent-of-origin effects can be caused by loci required for gametophyte development or by imprinted genes needed for seed development. Few parent-of-origin-effect loci have been identified in maize (Zea mays) even though there are a large number of imprinted genes known from transcriptomics. We screened rough endosperm (rgh) mutants for parent-of-origin effects using reciprocal crosses with inbred parents. Six maternal rough endosperm (mre) and three paternal rough endosperm (pre) mutants were identified with three mre loci mapped. When inherited from the female parent, mre/+ seeds reduce grain fill with a rough, etched, or pitted endosperm surface. Pollen transmission of pre mutants results in rgh endosperm as well as embryo lethality. Eight of the mutants had significant distortion from the expected one-to-one ratio for parent-of-origin effects. Linked markers for mre1, mre2, and mre3 indicated that the mutant alleles have no bias in transmission. Histological analysis of mre1, mre2, mre3, and pre*-949 showed altered timing of starch grain accumulation and basal endosperm transfer cell layer (BETL) development. The mre1 locus delays BETL and starchy endosperm development, while mre2 and pre*-949 cause ectopic starchy endosperm differentiation. We conclude that many parent-of-origin effects in maize have incomplete penetrance of kernel phenotypes and that there is a large diversity of endosperm developmental roles for parent-of-origin-effect loci.