bluuebunny/crossref_metadata_2025_split huggingface dataset:
Клинико-гормональные критерии оценки эффективности супрессивной терапии каберголином у больных с органической гиперпролактинемией
Authors: Khyzhniak O.O. , Hohitidze T.H. , Mykytiuk M.R. 
Published: December 2016

Актуальность. В современных международных рекомендациях не выделены критерии оценки клинических симптомов, в том числе со стороны соматического, неврологического статуса, хотя практически все нейроэндокринологи признают наличие именно неспецифических жалоб и симптомов у больных с органической гиперпролактинемией. Лечение органической гиперпролактинемии направлено на достижение восстановления нормального уровня биологически активного пролактина (ПРЛ) и уменьшение объема аденомы. Цель исследования — изучить клинико-гормональную эффективность разных режимов супрессивной терапии каберголином у больных с пролактиномами за период 12 месяцев. Материалы и методы исследования. Обследованы и прошли 12-месячный курс лечения селективным агонистом дофамина (АгДоф) каберголином (САВ) 61 пациент с пролактиномой (ПРОЛ) (52 женщины и 9 мужчин) в возрасте 16–66 лет. Общая длительность заболевания составляла от 1 до 60 мес., средняя — 12,3 ± 10,1 мес. Среди женщин, получавших терапию САВ, у 40 была микроПРОЛ, у 12 макро- и гигантская ПРОЛ. Среди мужчин у 2 была микроаденома, у 7 макроаденома. ПРОЛ верифицировали с помощью магнитно-резонансной томографии (МРТ). Уровень ПРЛ в крови (нг/мл) определяли иммуноферментным методом на автоматическом анализаторе Stat Fax 2100 (Awareness Technology, США) с помощью коммерческого набора реактивов ELISA (DRG Diagnostics, США). Применяли два режима терапии: первый — режим постепенного наращивания дозы САВ, начиная с 0,5 мг в неделю с последующим контролем уровня ПРЛ в крови каждые 4 нед. и титрацией дозы препарата при необходимости (увеличение недельной дозы на 0,25–0,5 мг). Второй — режим высоких стартовых доз из расчета: количество таблеток САВ (0,5 мг) соответствовало кратности повышения уровня ПРЛ в крови по отношению к верхней границе возрастной нормы, но не более 4 мг (8 таблеток) в неделю. Статистический анализ полученных данных проводили с использованием программного комплекса Statgraphics Plus for Windows 3.0 (Manugistic Inc. USA). Результаты. Предложена интегральная балльная система оценки клинико-гормональной эффективности супрессивной терапии САВ у больных с органической гиперпролактинемией, которая позволяет на всех этапах динамического наблюдения проводить коррекцию схемы лечения, оценить возможный риск от применения больших доз препарата и оптимизировать подбор адекватной дозы препарата. Оптимальным режимом терапии каберголином у пациентов с микропролактиномой является режим постепенного увеличения дозы, положительный клинико-гормональный эффект которого наблюдается у 80 % пациентов через 3 месяца после начала лечения. Выводы. Назначение режима высоких стартовых доз каберголина пациентам с макро- и гигантскими пролактиномами позволяет в более короткие сроки (через 1 мес.) добиться достоверной позитивной динамики показателей неврологического, общесоматического и гормонального статуса по сравнению с группой больных, получавших терапию в режиме постепенного увеличения дозы препарата.
Peculiarities of Indices of Thyroid Homeostasis in Patients with Metabolic Syndrome Depending on Body Mass Index
Authors: Abramova N.O. , Pashkovska N.V. 
Published: December 2016

Introduction. Nonthyroidal illness syndrome develops in patients against the background of chronic comorbidity as a result of impaired peripheral conversion of thyroid hormones and is characterized by low levels of triiodothyronine (T3).Objective of the study: to find out the features of thyroid homeostasis in patients with metabolic syndrome (MS).Materials and methods. 64 patients with MS and 20 healthy individuals were involved in the investigation. We determined the level of thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3). To study the functional status of the pituitary-thyroid axis, we calculated fT3/fT4 ratio and thyroid index (TI). Peripheral activity of thyroid hormones was estimated by total thyroid index (TTI).Results. In the course of our study, lower fT3 levels and increased levels of TSH and fT4 was revealed in patients with MS compared with the group of healthy subjects (p < 0.05). We found a reduction of fT3/fT4 ratio (p < 0.05) compared to the control group (p< 0.05). TTI was lower in the examined patients compared with the group of healthy individuals (p < 0.05).As a result of correlation analysis, it was established that body mass index negatively correlated with the level of fT3 (r = –0.341, p < 0.05), fT3/fT4 index (r = –0.458, p < 0.05), TI (r = –0.415, p < 0.05) and TTI (r = –0.335, p < 0.05) and positively — with levels of fT4 (r = 0.405, p < 0.05) and TSH (r = 0.327, p < 0.05).Conclusion. The obtained data suggests the development of nonthyroidal illness syndrome in patients with metabolic syndrome as a result of impaired peripheral conversion of thyroid hormones, which deepens with body mass index growth, i.e. the class of obesity.
Рівні васкулоендотеліального фактора росту у хворих на гіпотиреоз
Authors: Didushko O.M. 
Published: December 2016

Метою дослідження було визначення рівня васкулоендотеліального фактора росту у хворих на первинний гіпотиреоз. При обстеженні 133 пацієнтів з маніфестним гіпотиреозом виявлено, що суттєво зростав рівень васкулоендотеліального фактора росту в плазмі крові хворих як з ожирінням, так і без ­нього, проте найвищі показники зафіксовані у хворих із гіпотиреозом на тлі автоімунного тиреоїдиту та з ожирінням. Отримані кореляційні зв’язки вказують на взаємообтяжуючий вплив гіпофункції щитоподібної залози, ожиріння та гіперхолестеринемії на розвиток ендотеліальної дисфункції у хворих на первинний гіпотиреоз, зокрема зростання рівня васкулоендотеліального фактора росту.
Захворювання кістково-м’язової системи та вік: деякі основні аспекти (огляд симпозіуму)
Authors: Kuprinenko N. 
Published: December 2016

Зроблено короткий огляд ключових лекцій та доповідей, що були представлені під час Міжнародного симпозіуму «Захворювання кістково-м’язової системи та вік» 5–7 травня 2015 року у м. Львів, Україна.
Нейропатичний компонент болю в пацієнтів різного віку з остеоартрозом колінних суглобів
Authors: Povoroznyuk V.V. , Pryimych U.I. 
Published: December 2016

Механізми виникнення больового синдрому в пацієнтів з остеоартрозом залишаються маловивченими. Останні дані свідчать, що, окрім ноцицептивного механізму, у хворих на остеоартроз можуть спостерігатися ознаки центральної сенситизації та нейропатичний компонент болю. Метою дослідження було оцінити кількісні та якісні характеристики больового синдрому й визначити частоту ймовірного нейропатичного компонента болю в пацієнтів різного віку з первинним остеоартрозом (ОА) колінних суглобів за допомогою скринінгових опитувальників, виявити найбільш специфічні ознаки та симптоми нейропатичного болю (НБ) у даної категорії хворих. Матеріали та методи. Обстежено 37 пацієнтів жіночої статі віком від 47 до 85 років з клініко-рентгенологічними проявами первинного ОА колінних суглобів (II–III ст. за Kellgren-Lawrence, 1957) та тривалістю больового синдрому понад 1 міс. Пацієнти згідно з геронтологічною класифікацією були розподілені на 3 вікові категорії: пацієнти середнього (47–59 років), літнього (60–74 роки) та старечого віку (75–89 років). Для виявлення нейропатичного компонента болю використовували скринінгові опитувальники (шкали) нейропатичного болю — painDETECT, LANSS, DN4. Додатково пацієнти заповнювали візуально-аналогову шкалу (ВАШ), опитувальник Мак-Гілла, WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index). Оцінку якості життя визначали за допомогою EuroQol-5D. Для статистичної обробки результатів використовували регресійно-кореляційний аналіз, ANOVA, хі-квадрат (χ2). Статистично вірогідними результати вважали при р < 0,05. Результати. За даними опитувальника painDETECT у пацієнтів з ОА колінних суглобів (n = 37) малоймовірний нейропатичний біль зустрічався у 70,3 % (n = 26), можливий (невизначений) — у 24,3 % (n = 9), ймовірний НБ — у 5,4 % (n = 2). Згідно з даними шкали LANSS ймовірний НБ знайдено у 29,7 % обстежених (n = 11), малоймовірний — у 70,3 % (n = 26). За даними DN4 ймовірний НБ виявили у 35,1 % (n = 13), малоймовірний — у 64,9 % (n = 24). Виявлено тісні кореляційні зв’язки між шкалами нейропатичного болю painDETECT i LANSS (r = 0,76; p < 0,001) та painDETECT і DN4 (r = 0,86; p < 0,001). За допомогою кореляційного аналізу встановлено помірні кореляційні зв’язки між показниками ВАШ та показниками всіх скринінгових опитувальників нейропатичного болю — painDETECT (r = 0,4; p < 0,05), LANSS (r = 0,4; p < 0,05), DN4 (r = 0,42; p < 0,05).
Effectiveness of manual bladder expression in paraplegic dogs
Authors: Carwardine Darren R. , Rose Jeremy H. , Harcourt-Brown Thomas R. , Granger Nicolas 
Published: December 2016

Abstract
OBJECTIVE
To determine the effectiveness of manual bladder expression in paraplegic dogs by comparing urine volumes measured by use of intermittent catheterization and ultrasonography.
ANIMALS
36 paraplegic dogs.
PROCEDURES
93 measurements of bladder volume were collected for the 36 dogs. Residual urine volume was determined by use of intermittent urethral catheterization and estimated by use of ultrasonography.
RESULTS
Manual bladder expression voided a mean of 49% of urine from the bladder in this population of dogs. There was no correlation (R2, 0.06) between the effectiveness of manual bladder expression and body weight. Ultrasonographic estimation of bladder volume had good correlation (R2, 0.62) with bladder volume determined by use of intermittent bladder catheterization, but clinically unacceptable variation for predicting actual bladder volume (mean difference, 22 mL; 95% confidence interval, −96 to 139 mL).
CONCLUSIONS AND CLINICAL RELEVANCE
Manual bladder expression was ineffective at completely emptying urine from the bladder of paraplegic dogs, but the effectiveness of the procedure was not affected by body weight. Manual bladder expression would likely be a useful procedure to prevent increases in pressure within the bladder. Ultrasonographic estimation of bladder volume could be a useful predictor of actual bladder volume, but it was susceptible to wide variations among dogs, and results should therefore be interpreted with caution.
Evaluation of gastroscopy and biopsy of the proventriculus and ventriculus in pigeons (Columba livia)
Authors: Sladakovic Izidora , Ellis Angela E. , Divers Stephen J. 
Published: December 2016

Abstract
OBJECTIVE To evaluate the efficacy and safety of gastroscopy and biopsy of the proventriculus and ventriculus in pigeons (Columba livia).
ANIMALS 15 adult pigeons.
PROCEDURES Each pigeon was anesthetized, and the upper gastrointestinal tract (from the cervical portion of the esophagus to the ventriculus) was endoscopically evaluated by use of a rigid endoscope inserted orally. Saline (0.9% NaCl) solution was orally infused to achieve lumen dilation and visibility. Two mucosal biopsy specimens were collected from each of the proventriculus and ventriculus, histologically evaluated, and graded for crush artifacts and depth. Pigeons were monitored for adverse effects for 3 to 6 days after the procedure, after which they were euthanized for necropsy.
RESULTS Gastroscopy via the oral approach provided excellent visibility of the lumen and mucosal surfaces of the proventriculus and cranial portion of the ventriculus and was safe provided that appropriate precautions were taken. Two intraoperative deaths occurred at the beginning of the study; following procedure refinement, no additional deaths occurred. No major adverse effects of the procedure were detected in the remaining 13 pigeons during the postoperative monitoring period or at necropsy. Diagnostic quality of proventriculus specimens was adequate for 10 of 13 pigeons. Eight of 13 ventriculus specimens were of inadequate quality, and only 3 were of adequate quality.
CONCLUSIONS AND CLINICAL RELEVANCE Gastroscopy was useful for evaluating the lumen and mucosal surface of the proventriculus and ventriculus in pigeons, and biopsy of those organs was safely performed with the appropriate technique. Further evaluation of these techniques is needed in birds with clinical disease and birds of other species.
Survivability of Mycobacterium bovis on salt and salt-mineral blocks fed to cattle
Authors: Kaneene John B. , Hattey Joseph A. , Bolin Carole A. , Averill James , Miller RoseAnn 
Published: December 2016

Abstract
OBJECTIVE To determine the survivability of Mycobacterium bovis on salt and salt-mineral blocks in typical weather conditions in Michigan over two 12-day periods at the height of summer and winter.
SAMPLE 4 salt (NaCl) and 4 salt-mineral blocks inoculated with pure cultures of a strain of M bovis currently circulating in Michigan livestock and wildlife.
PROCEDURES In the summer and again in the winter, inoculated blocks were placed in secured outdoor facilities where equal numbers of each block type (2/type/season) were exposed to shade or sunlight. Samples were collected from randomly selected areas on the surface of each block beginning within 1 hour after placement (day 0) twice a day for the first 4 days and once a day from days 7 through 11. Bacterial culture of samples was performed to detect viable M bovis.
RESULTS Depending on the exposure conditions, salt blocks yielded viable M bovis for up to 2 days after inoculation and salt-mineral blocks yielded viable M bovis for > 3 days. Survival time was greatest on salt-mineral blocks kept outdoors in the shade during the winter. The odds of recovering viable M bovis from salt-mineral block samples were 4.9 times as great during the winter (vs the summer) and 3.0 times as great with exposure to shade (vs sunlight).
CONCLUSIONS AND CLINICAL RELEVANCE Results from this study indicated that salt and salt-mineral blocks should be considered potential sources of bovine tuberculosis when designing risk mitigation programs for cattle herds in areas with wildlife reservoirs of M bovis.
Corneal thickness of eyes of healthy goats, sheep, and alpacas manually measured by use of a portable spectral-domain optical coherence tomography device
Authors: LoPinto Alexander J. , Pirie Chris G. , Bedenice Daniela , Ayres Sandra L. 
Published: December 2016

Abstract
OBJECTIVE
To determine corneal thickness of eyes of healthy goats, sheep, and alpacas by use of a portable spectral-domain optical coherence tomography (SD-OCT) device and evaluate intraoperator reliability for measurements.
ANIMALS
11 female goats, 10 female sheep, and 11 (4 males and 7 females) alpacas.
PROCEDURES
Each animal was sedated, and gentle manual restraint was used to ensure proper positioning of the head and globe. Corneal pachymetry was performed (in triplicate) with a portable SD-OCT device on both eyes of each animal. All corneal measurements were obtained manually by use of the integrated caliper function. Corneal epithelial thickness (CET), corneal stromal thickness (CST), Descemet membrane thickness (DMT), and total corneal thickness (TCT) were measured twice on each image, and a mean value was calculated.
RESULTS
Mean ± SD values for CET, CST, DMT, and TCT were 96.1 ± 5.0 μm, 486.0 ± 10.3 μm, 36.8 ± 4.8 μm, and 616.9 ± 7.1 μm, respectively, for the goats; 111.6 ± 5.7 μm, 599.8 ± 10.0 μm, 31.0 ± 4.5 μm, and 741.1 ± 9.9 μm, respectively, for the sheep; and 147.4 ± 5.7 μm, 446.1 ± 7.4 μm, 44.5 ± 5.0 μm, and 634.8 ± 6.2 μm, respectively, for the alpacas. Intraclass correlations ranged from 0.49 to 0.83 for CET, CST, and TCT and from 0.13 to 0.36 for DMT.
CONCLUSIONS AND CLINICAL RELEVANCE
SD-OCT provided manual measurement of corneal thickness (CET, CST, and TCT) with clinically acceptable intraoperator reliability for eyes of healthy goats, sheep, and alpacas.
Effects of diurnal variation and anesthetic agents on intraocular pressure in Syrian hamsters (Mesocricetus auratus)
Authors: Rajaei Seyed Mehdi , Mood Maneli Ansari , Paryani Mohammad Reza , Williams David L. 
Published: December 2016

Abstract
OBJECTIVE
To determine effects of diurnal variation and anesthetic agents on intraocular pressure (IOP) in Syrian hamsters (Mesocricetus auratus).
ANIMALS
90 healthy adult Syrian hamsters (45 males and 45 females).
PROCEDURES
IOP was measured with a rebound tonometer. In phase 1, IOP was measured in all hamsters 3 times during a 24-hour period (7 am, 3 pm, and 11 pm). In phase 2, hamsters were assigned to 5 groups (18 animals [9 males and 9 females]/group). Each group received an anesthetic agent or combination of anesthetic agents (ketamine hydrochloride, xylazine hydrochloride, diazepam, ketamine-diazepam [KD], or ketamine-xylazine [KX] groups) administered via the IP route. The IOP was measured before (time 0 [baseline]) and 10, 30, 60, 90, 120, and 150 minutes after administration of drugs.
RESULTS
Mean ± SD IOP values were 2.58 ± 0.87 mm Hg, 4.46 ± 1.58 mm Hg, and 5.96 ± 1.23 mm Hg at 7 am, 3 pm, and 11 pm, respectively. Mean baseline IOP was 6.25 ± 0.28 mm Hg, 6.12 ± 0.23 mm Hg, 5.75 ± 0.64 mm Hg, 5.12 ± 1.40 mm Hg, and 4.50 ± 1.30 mm Hg for the ketamine, xylazine, diazepam, KD, and KX groups, respectively. A significant decrease in IOP, compared with baseline IOP, was detected in only the KX group at 30, 60, and 90 minutes after drug administration.
CONCLUSIONS AND CLINICAL RELEVANCE
Maximum IOP in Syrian hamsters was detected at night. The ketamine-xylazine anesthetic combination significantly decreased IOP in Syrian hamsters.
DETECTION OF ROTATIONAL SPECTRAL VARIATION ON THE M-TYPE ASTEROID (16) PSYCHE
Authors: Sanchez Juan A. , Reddy Vishnu , Shepard Michael K. , Thomas Cristina , Cloutis Edward A. , Takir Driss , Conrad Albert , Kiddell Cain , Applin Daniel 
Published: December 2016

ABSTRACT
The asteroid (16) Psyche is of scientific interest because it contains ∼1% of the total mass of the asteroid belt and is thought to be the remnant metallic core of a protoplanet. Radar observations have indicated the significant presence of metal on the surface with a small percentage of silicates. Prior ground-based observations showed rotational variations in the near-infrared (NIR) spectra and radar albedo of this asteroid. However, no comprehensive study that combines multi-wavelength data has been conducted so far. Here we present rotationally resolved NIR spectra (0.7–2.5 μm) of (16) Psyche obtained with the NASA Infrared Telescope Facility. These data have been combined with shape models of the asteroid for each rotation phase. Spectral band parameters extracted from the NIR spectra show that the pyroxene band center varies from ∼0.92 to 0.94 μm. Band center values were used to calculate the pyroxene chemistry of the asteroid, whose average value was found to be Fs30En65Wo5. Variations in the band depth (BD) were also observed, with values ranging from 1.0% to 1.5%. Using a new laboratory spectral calibration method, we estimated an average orthopyroxene content of 6% ± 1%. The mass-deficit region of Psyche, which exhibits the highest radar albedo, also shows the highest value for the spectral slope and the minimum BD. The spectral characteristics of Psyche suggest that its parent body did not have the typical structure expected for a differentiated body or that the sequence of events that led to its current state was more complex than previously thought.
DETECTION OF WATER AND/OR HYDROXYL ON ASTEROID (16) Psyche
Authors: Takir Driss , Reddy Vishnu , Sanchez Juan A. , Shepard Michael K. , Emery Joshua P. 
Published: December 2016

ABSTRACT
In order to search for evidence of hydration on M-type asteroid (16) Psyche, we observed this object in the 3 μm spectral region using the long-wavelength cross-dispersed (LXD: 1.9–4.2 μm) mode of the SpeX spectrograph/imager at the NASA Infrared Telescope Facility. Our observations show that Psyche exhibits a 3 μm absorption feature, attributed to water or hydroxyl. The 3 μm absorption feature is consistent with the hydration features found on the surfaces of water-rich asteroids, attributed to OH- and/or H2O-bearing phases (phyllosilicates). The detection of a 3 μm hydration absorption band on Psyche suggests that this asteroid may not be a metallic core, or it could be a metallic core that has been impacted by carbonaceous material over the past 4.5 Gyr. Our results also indicate rotational spectral variations, which we suggest reflect heterogeneity in the metal/silicate ratio on the surface of Psyche.
GEMINI NEAR INFRARED FIELD SPECTROGRAPH OBSERVATIONS OF THE SEYFERT 2 GALAXY MRK 573: IN SITU ACCELERATION OF IONIZED AND MOLECULAR GAS OFF FUELING FLOWS
Authors: Fischer Travis C. , Machuca C. , Diniz M. R. , Crenshaw D. M. , Kraemer S. B. , Riffel R. A. , Schmitt H. R. , Baron F. , Storchi-Bergmann T. , Straughn A. N. , Revalski M. , Pope C. L. 
Published: December 2016

ABSTRACT
We present near-infrared and optical emission-line and stellar kinematics of the Seyfert 2 galaxy Mrk 573 using the Near-Infrared Field Spectrograph (NIFS) at Gemini North and Dual Imaging Spectrograph at Apache Point Observatory, respectively. By obtaining full kinematic maps of the infrared ionized and molecular gas and stellar kinematics in a ∼700 × 2100 pc2 circumnuclear region of Mrk 573, we find that kinematics within the Narrow-Line Region are largely due to a combination of both rotation and in situ acceleration of material originating in the host disk. Combining these observations with large-scale, optical long-slit spectroscopy that traces ionized gas emission out to several kpcs, we find that rotation kinematics dominate the majority of the gas. We find that outflowing gas extends to distances less than 1 kpc, suggesting that outflows in Seyfert galaxies may not be powerful enough to evacuate their entire bulges.
TIME DELAY ANALYSIS OF THE LENSED QUASAR SDSS J1001+5027
Authors: Aghamousa Amir , Shafieloo Arman 
Published: December 2016

ABSTRACT
We modify the algorithm we proposed in Aghamousa & Shafieloo for the time delay estimation of strongly lensed systems incorporating the weighted cross-correlation and weighted summation of correlation coefficients. We show the high performance of this algorithm by applying it to Time Delay Challenge (TDC1) simulated data. We apply then our proposed method to the light curves of the lensed quasar SDSS J1001+5027 since this system has been well studied by other groups, to compare our results with their findings. In this work we propose a new estimator, the “mirror” estimator, along with a list of criteria for reliability testing of the estimation. Our mirror estimator results are

and

using simple Monte Carlo simulations and simulated light curves provided by Rathna Kumar et al., respectively. Although the TDC1 simulations do not reflect the properties of the SDSS J1001+5027 light curves, using these simulations results in a smaller uncertainty, which shows that the higher quality observations can lead to a substantially more precise time delay estimation. Our time delay estimation is in agreement with the findings of the other groups for this strongly lensed system, and the difference in the size of the error bars reflects the importance of appropriate light curve simulations.