bluuebunny/crossref_metadata_2025_split huggingface dataset:
X‐ray absorption spectroscopy study of synthetic cobalt blue pigments similar to Kangxi blue and white porcelain
Authors: Luo Mi , Zhang Maolin , Yan Wensheng , Wang Lihua , Jiang Zheng 
Published: November 2017

AbstractA series of cobalt blue pigments, which were synthesized based on the chemical compositions of the blue pigments in Kangxi blue and white porcelain, were investigated by Co, Mn, and Fe K‐edge and L2,3‐edge X‐ray absorption spectroscopy to determine the oxidation states and species of the elements and to discern their impact on the blue color. The results reveal that Co is bivalent and mainly located at tetrahedral sites, which is the main parameter controlling the blue color. Mn is mainly present as Mn2+, or CoxZn1‐xAl2O4 and Fe is mainly present as Fe3+. In particular, Fe3+ substitutes the Al in CoAl2O4 and occupies octahedral sites with a high Mn content. All the synthetic cobalt blue pigments can form a solid solution with various end‐members or an intermediate solution spinel. The spectroscopic determination of the oxidation states and speciation of Co, Mn, and Fe furthers understanding of the coloration of blue pigments in blue and white porcelain.
The fate of iron during the alkali‐activation of synthetic (CaO‐)FeOx‐SiO2 slags: An Fe K‐edge XANES study
Authors: Simon Sebastian , Gluth Gregor J. G. , Peys Arne , Onisei Silviana , Banerjee Dipanjan , Pontikes Yiannis 
Published: November 2017

AbstractSlags from the nonferrous metals industry have great potential to be used as feedstocks for the production of alkali‐activated materials. Until now, however, only very limited information has been available about the structural characteristics of these materials. In the work presented herein, synthetic slags in the CaO–FeOx–SiO2 system, representing typical compositions of Fe‐rich slags, and inorganic polymers (IPs) produced from the synthetic slags by activation with alkali silicate solutions have been studied by means of X‐ray absorption near‐edge structure (XANES) spectroscopy at the Fe K‐edge. The iron in the slags was largely Fe2+, with an average coordination number of approximately 5 for the iron in the amorphous fraction. The increase in average oxidation number after alkali‐activation was conceptualized as the consequence of slag dissolution and IP precipitation, and employed to calculate the degrees of reaction of the slags. The degree of reaction of the slags increased with increasing amorphous fraction. The iron in the IPs had an average coordination number of approximately 5; thus, IPs produced from the Fe‐rich slags studied here are not Fe‐analogs of aluminosilicate geopolymers, but differ significantly in terms of structure from the latter.
Down‐regulating Myoferlin inhibits the vasculogenic mimicry of melanoma via decreasing MMP‐2 and inducing mesenchymal‐to‐epithelial transition
Authors: Zhang Wenxue , Zhou Ping , Meng Ai , Zhang Rongxin , Zhou Yan 
Published: November 2017

AbstractVasculogenic mimicry (VM) constitutes a novel approach for tumour blood supply and contributes to tumour metastasis and poor prognosis in patients with melanoma. Myoferlin (MYOF), a type II membrane protein involved in membrane regeneration and repair, is elevated in several malignant tumours, especially in advanced melanomas. This study aims to investigate the role and mechanism of MYOF in the regulation of VM. VM structures were found in 14 of 52 tested melanoma samples, and high MYOF expression correlated with VM structures. According to Kaplan–Meier survival curves, VM channels and elevated MYOF expression both correlated with poor prognosis in melanoma patients. Down‐regulation of MYOF by siRNA severely impaired the capability of A375 cells to form VM structures in vitro. Further studies demonstrated MYOF knockdown inhibited cell migration and invasion, which is required for VM formation, via decreasing MMP‐2 expression as evidenced by Western blotting, RT‐RCP and ELISA results. SB‐3CT, a specific inhibitor of MMP‐2, showed similar inhibiting effects with siMYOF, further supporting that MYOF down‐regulation inhibits MMP‐2 expression to affect VM formation. Moreover, MYOF knockdown suppress VM formation by A375 cells by inducing mesenchymal‐to‐epithelial transition (MET). After down‐regulating MYOF, focal adhesions were enlarged and A375 cells developed into a clear epithelial morphology. Such cells acquired the expression of E‐cadherin at adherens junctions along with a loss of mesenchymal markers, such as Vimentin and Twist1. In conclusion, MYOF plays an important role in VM and knockdown of MYOF suppresses VM formation via decreasing MMP‐2 and inducing MET in A375 melanoma cells.
Levels of serum retinol‐binding protein 4 before and after non‐surgical periodontal treatment in lean and obese subjects: An interventional study
Authors: Martinez‐Herrera Mayte , Silvestre Francisco Javier , Silvestre‐Rangil Javier , López‐Domènech Sandra , Bañuls Celia , Rocha Milagros 
Published: November 2017

AbstractAimWe aimed to evaluate serum RBP4 levels before and after periodontal therapy in lean and obese subjects with chronic periodontitis (CP) in order to determine its possible association with periodontitis.Materials and MethodsThis is an interventional study for which a total of 112 lean and 119 obese subjects were recruited. Patients with CP were evaluated before and after three months of non‐surgical periodontal treatment. Periodontal, anthropometric, biochemical parameters and serum levels of TNF‐α, IL‐6, hs‐CRP and RBP4 were assessed.ResultsSerum RBP4 levels were associated with an increased probability of periodontitis (OR = 1.60; 95% CI: 1.02‐2.50), showing patients with CP to have higher RBP4 levels than those without CP in both lean and obese populations (3.35 vs 3.06 and 3.74 vs 3.21, respectively). Following periodontal treatment, RBP4 and TNF‐α decreased, and all periodontal parameters improved to the same extent in both groups, except for number of teeth with probing depth (PD) ≥4 mm, which improved to a less extent in obese than in lean subjects. In the multivariable regression model, the number of teeth with PD ≥4 mm was independently associated with RBP4 (β = 0.192).ConclusionRBP4 was associated with chronic periodontitis before and after non‐surgical periodontal treatment.
Patients with Spitz naevi in the Greek population: Epidemiologic, Clinical and Histopathological characteristics
Authors: Soura E. , Dimitrakopoulou A. , Christofidou E. , Katoulis A. , Antoniou C. , Stratigos A. 
Published: November 2017

AbstractBackgroundSpitz naevi may present with clinical and histopathological atypical features that do not affect patient prognosis but may become worrisome for patients ≥40 years presenting with newly appearing SN.ObjectivePatient characteristics and sun behaviour patterns were investigated in correlation with age. SN characteristics and histopathological attributes were also investigated in correlation with age.MethodsPatients with histopathologically confirmed diagnosis of SN were invited for a clinical examination. Data such as skin type, number of banal/atypical naevi, sun exposure patterns and personal/family history were collected. Histopathology preparations were re‐examined by two different histopathologists, and characteristics were collected based on a prespecified checklist. Patients were afterwards followed up every 6 months.ResultsA total of 110 patients with SN were identified and assigned to three age groups. The most common area of presentation was the trunk, for the ≥40 years age group, and the limbs for the other age groups. Patients ≥40 years had a higher possibility of presenting with a naevus count ≥50 and at least one atypical naevus compared to the other age groups. Patients ≥40 years presented more commonly with a history of painful sunburn (100%) before the appearance of the SN, used less sunscreen, had higher sun exposure times and more clinical signs of solar skin damage compared to the other age groups. Finally, patients ≥40 years presented more commonly with signs of histopathological atypia such as the presence of mitoses, cellular atypia and prominent nucleolus.ConclusionPatients ≥40 were more likely to report a history of longer sun exposure times, of never using a sunscreen and of having a history of painful sunburn. However, the importance of this observation remains to be elucidated as these patients also presented more commonly with lesions located on non‐sun‐exposed areas (trunk) and higher naevus/atypical naevus counts.
Characterization of the Parasitic Dinoflagellate Amoebophrya sp. Infecting Akashiwo sanguinea in Coastal Waters of China
Authors: Chen Tiantian , Liu Yun , Song Shuqun , Li Caiwen 
Published: November 2017

AbstractThe endoparasitic dinoflagellate Amoebophrya infects a number of free‐living marine dinoflagellates, including harmful algal bloom species. The parasitoid eventually kills its host and has been proposed to be a significant loss factor for dinoflagellate blooms in restricted coastal waters. For several decades, the difficulties of culturing host‐parasitoid systems have been a great obstacle for further research on the biology of Amoebophrya. Here, we established an Akashiwo sanguinea‐Amoebophrya sp. coculture from Chinese coastal waters and studied the parasitoid's generation time, dinospore survival and infectivity, as well as its host specificity. The lifespan of Amoebophrya sp. ex. A. sanguinea was approximately 58 h. The infective dinospores can survive up to 78 h in ambient waters but gradually lose their infectivity. The parasitoid was unable to infect other dinoflagellate species, its infection rate reached as high as 91% when the ratio of dinospores to host cells was 20:1. The high infectivity of dinospores suggests that the Amoebophrya strain was capable of removing a considerable fraction of host biomass within a short period, but that it is probably unable to maintain high infection levels under nonbloom conditions of its host, due to limited survival and time constraints in encountering host cells.
Frequency of Leaving the House and Mortality from Age 70 to 95
Authors: Jacobs Jeremy M. , Hammerman‐Rozenberg Aliza , Stessman Jochanan 
Published: November 2017

ObjectivesTo determine the association between frequency of leaving the house and mortality.DesignProspective follow‐up of an age‐homogenous, representative, community‐dwelling birth cohort (born 1920–21) from the Jerusalem Longitudinal Study (1990–2015).SettingHome.ParticipantsIndividuals aged 70 (n = 593), 78 (n = 973), 85 (n = 1164), and 90 (n = 645), examined in 1990, 1998, 2005, and 2010, respectively.MeasurementsFrequency of leaving the house, defined as daily (6–7/week), often (2–5/week), and rarely (≤1/week); geriatric assessment; all‐cause mortality (2010–15). Kaplan‐Meier survival charts and proportional hazards models adjusted for social (sex, marital status, financial status, loneliness), functional (sex, self‐rated health, fatigue, depression, physical activity, activity of daily living difficulty), and medical (sex, chronic pain, visual impairment, hearing impairment, diabetes mellitus, hypertension, ischemic heart disease, chronic kidney disease) covariates.ResultsAt ages 70, 78, 85, and 90, frequency of going out daily was 87.0%, 80.6%, 65.6%, and 48.4%; often was 6.4%, 9.5%, 17.4%, and 11.3%; and rarely was 6.6%, 10.0%, 17.0%, and 40.3% respectively. Decreasing frequency of going out was associated with negative social, functional, and medical characteristics. Survival rates were lowest among those leaving rarely and highest among those going out daily throughout follow‐up. Similarly, compared with rarely leaving the house, unadjusted mortality hazard ratios (HRs) were lowest among subjects leaving daily and remained significant after adjustment for social, functional and medical covariates. Among subjects leaving often, unadjusted HRs showed a similar effect of smaller magnitude, with attenuation of significance after adjustment in certain models. Findings were unchanged after excluding subjects dying within 6 months of follow‐up.ConclusionIn community‐dwelling elderly adults aged 70 to 90, leaving the house daily was associated with lower mortality risk, independent of social, functional, or medical status.
Calmodulin‐like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease
Authors: Kusakari Shinya , Nawa Mikiro , Sudo Katsuko , Matsuoka Masaaki 
Published: November 2017

AbstractHumanin and calmodulin‐like skin protein (CLSP) inhibits Alzheimer disease (AD)‐related neuronal cell death via the heterotrimeric humanin receptor in vitro. It has been suggested that CLSP is a central agonist of the heterotrimeric humanin receptor in vivo. To investigate the role of CLSP in the AD pathogenesis in vivo, we generated mouse CLSP‐1 transgenic mice, crossed them with the APPswe/PSEN1dE9 mice, a model mouse of AD, and examined the effect of CLSP over‐expression on the pathological phenotype of the AD mouse model. We found that over‐expression of the mouse CLSP‐1 gene attenuated spatial learning impairment, the loss of a presynaptic marker synaptophysin, and the inactivation of STAT3 in the APPswe/PSEN1dE9 mice. On the other hand, CLSP over‐expression did not affect levels of Aβ, soluble Aβ oligomers, or gliosis. These results suggest that the CLSP‐mediated attenuation of memory impairment and synaptic loss occurs in an Aβ‐independent manner. The results of this study may serve as a hint to the better understanding of the AD pathogenesis and the development of AD therapy.
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The Queer Art of Biblical Reading: Matthew 25:31–46 (Caritas Christiana) ThroughCaritas Romana
Authors: Menéndez‐Antuña Luis 
Published: November 2017

AbstractThe place of eros in Christian theology has always been a contested one, not least because it is positioned as being at odds with agape, the kind of love that embodies gospel ethics. Matthew 25:31–46 calls us to “feed the hungry,” “quench the thirsty,” “shelter the homeless,” “clothe the naked,” and “visit the imprisoned” as emblematic examples of agapic love. This essay shows how a queer act, specifically that of a woman breastfeeding a starving man as depicted in the tradition ofCaritas Romana, can fulfill the ethical demands in Matthew's pericope. It demonstrates how the action first narrated by Valerius Maximus and then represented by Paul Peter Rubens beautifully fulfills the Matthean agapic demands, and concludes that queer practices have the potential to fulfill the gospel demands, situating the erotic at the core of the agapic.
Discussing Racial Justice in Light of 2016: Black Lives Matter, a Trump Presidency, and the Continued Struggle for Justice
Authors: Teresa Dávila María 
Published: November 2017

AbstractThe broad fields of ethical reflection on racialization, racial justice, black liberation theology, and queer theology of color must come to terms with the year 2016, which can be framed on one side with the Black Lives Matter movement, and on the other side with a presidential election cycle in which racism and racial justice played particularly salient roles. Against this backdrop, this book discussion looks at recent literature on racial justice asking three questions. How does historical consciousness shape contemporary ethical thought on racial justice? In what ways do the intersectionalities of gender and sexuality, immigration and transnationality, class, and contemporary culture present particular challenges and new possibilities? And how do the ethical frameworks of religious traditions contribute to the development of public theology for racial justice? The conclusion considers how religious ethics concerned with racial justice does harm or contributes to religiously grounded responses to racial injustice. Reflection on these questions points to the need for ongoing engagement with the black experience—broadly construed and within the context of multiple intersections—in the United States and globally in ethical analysis. However, this in turn makes particular and critical demands on how it is that we are to both teach and read religious ethics and political theology at our institutions, as well as in the churches.
Comparing preferred attribute elicitation to trained panelists' evaluations using a novel food product
Authors: McSweeney Matthew B. , Sisopha Anita , T'ien Caroline , Rector Megan , Duizer Lisa M. 
Published: November 2017

AbstractThe present study compares a new rapid sensory method, preferred attribute elicitation (PAE), to a trained panelists' evaluations, using cookies containing green tea extract (GTE) as a model. The cookies contained added amounts of 0, 2, 4, 7, and 9% GTE based on the weight of flour. Ten trained panelists evaluated the cookies. The panelists were trained for 10 one‐hour sessions followed by three replicates of testing. Additionally, 43 panelists in two different sessions (n = 25 and 18), evaluated the five samples following the PAE method. RV coefficients were used to provide a numerical value for the degree of similarity between the descriptive data obtained from the PAE sessions and the descriptive analysis panel. The RV coefficient for the two PAE sessions was .843, indicating a very high similarity between the sessions. However, the RV coefficient comparing the two PAE sessions to the descriptive analysis data were .554 and .179, respectively. These results indicate that the PAE method was not comparable to the trained panelists' evaluations. Future work needs to identify when PAE is the most suitable method to use and to modify the existing methodology to make it a more efficient method.Practical applicationsPreferred attribute elicitation (PAE) is a rapid sensory analysis method that uses untrained panelists to evaluate attributes of a product and determine what attributes drive consumer liking. This study investigates how the technique (using untrained panelist) compares to a trained panel when testing baked products differing in flavor intensity. There was not a relationship between the PAE sessions and trained panel for the flavors of this particular product. More work must be done to determine why the evaluations of the flavor was not consistent if PAE is to be used in future sensory trials.
Contextual Factors Associated with Implementing Active Support in Community Group Homes in the United States: A Qualitative Investigation
Authors: Qian Xueqin , Tichá Renáta , Stancliffe Roger 
Published: November 2017

AbstractAlthough numerous studies in the U.K. and Australia have shown that Active Support (AS) is an effective intervention in increasing staff assistance and engagement for people with intellectual and developmental disabilities (IDD) who live in small community residential settings, studies in Taiwan and the U.S. did not replicate these results. The mixed findings may be due to the unique challenges faced by small community group homes serving people with disabilities from different countries. The purpose of this qualitative study was to describe the views of participants in a AS implementation study about contextual factors that affected their efforts at implementing AS in a U.S. context. Interviews were conducted with Direct Support Professionals (DSPs) and AS trainers. A focus group was conducted with directors from organizations that implemented AS in the U.S. This study revealed several reported challenges to AS implementation, including the lack of leadership support, lack of buy‐in, and high staff turnover rate. Despite these difficulties, study participants identified positive impacts of AS on both DSPs and people with disabilities. Implications of these findings are discussed.
The thrill of bullying. Bullying, humour and the making of community
Authors: Søndergaard Dorte Marie 
Published: November 2017

AbstractHumour can be utilised to mark out the boundaries of social groups, to produce and restore dignity, but also to produce contempt, marginalise and exclude. Humour and ridicule can be used to influence hierarchies and positioning among children in the classroom and it can have strong effects in school groups saturated with bullying practices. Ridicule appears to be widespread, very much feared, and not easily amenable to adult interventions. With this article, I look into the many and frequently subtle ways humour intertwines itself in relational practices among children, with a particular focus on children in groups plagued by bullying and social tension. I focus on the entanglement of humour in the complex manoeuvrings that characterise children's worlds, and the subtle mechanisms involved in the self‐regulation of their communities in and outside schools. The analyses and analytical understanding that I develop are grounded in qualitative data such as interviews with children and extensive observation in schools and in after school care.
Pharmacokinetic profiles of the two major active metabolites of metamizole (dipyrone) in cats following three different routes of administration
Authors: Lebkowska‐Wieruszewska B. , Kim T. W. , Chea B. , Owen H. , Poapolathep A. , Giorgi M. 
Published: November 2017

This study was performed to determine pharmacokinetic profiles of the two active metabolites of the analgesic drug metamizole (dipyrone, MET), 4‐methylaminoantipyrine (MAA), and 4‐aminoantipyrine (AA), after intravenous (i.v., intramuscular (i.m.), and oral (p.o.) administration in cats. Six healthy mixed‐breed cats were administered MET (25 mg/kg) by i.v., i.m., or p.o. routes in a crossover design. Adverse clinical signs, namely salivation and vomiting, were detected in all groups (i.v. 67%, i.m. 34%, and p.o. 15%). The mean maximal plasma concentration of MAA for i.v., i.m., and p.o. administrations was 148.63 ± 106.64, 18.74 ± 4.97, and 20.59 ± 15.29 μg/ml, respectively, with about 7 hr of half‐life in all routes. Among the administration routes, the area under the plasma concentration curve (AUC) value was the lowest after i.m. administration and the AUCEV/i.v. ratio was higher in p.o. than the i.m. administration without statistical significance. The plasma concentration of AA was detectable up to 24 hr, and the mean plasma concentrations were smaller than MAA. The present results suggest that MET is converted into the active metabolites in cats as in humans. Further pharmacodynamics and safety studies should be performed before any clinical use.
Insecticide susceptibility status in Mexican populations of Stegomyia aegypti (= Aedes aegypti): a nationwide assessment
Authors: KURI‐MORALES P. A. , CORREA‐MORALES F. , GONZÁLEZ‐ACOSTA C. , MORENO‐GARCIA M. , SANTOS‐LUNA R. , ROMÁN‐PÉREZ S. , SALAZAR‐PENAGOS F. , LOMBERA‐GONZÁLEZ M. , SÁNCHEZ‐TEJEDA G. , GONZÁLEZ‐ROLDÁN J. F. 
Published: November 2017

AbstractIn Mexico, mosquito vector‐borne diseases are of public health concern as a result of their impact on human morbidity and mortality. The use of insecticides against adult mosquitoes is one of the most common ways of controlling mosquito population densities. However, the use of these compounds has resulted in the development of insecticide resistance. The aim of this study was to estimate susceptibility to six pyrethroids, two carbamates and two organophosphates in Mexican populations of Stegomyia aegypti (Linnaeus, 1762) (= Aedes aegypti) (Diptera: Culicidae) mosquitoes. Bottle insecticide susceptibility tests, with 1 h exposure, were performed on adult mosquitoes from 75 localities across 28 states. At 30 min of exposure, the proportion of fallen mosquitoes was recorded. After 60 min of exposure, mosquitoes were recovered in non‐treated containers and mortality was determined at 24 h after the set‐up of the experiment. In general, the carbamate insecticides represented the most effective group in terms of the proportion of mosquitoes fallen at 30 min (72–100%) and 24‐h mortality (97–100%). High and widespread resistance to pyrethroids Types I and II and, to a lesser extent, to organophosphates was observed. Insecticide susceptibility among and within states was highly variable.