bluuebunny/crossref_metadata_2025_split huggingface dataset:
إدارة الاحتواء وعلاقتها بتعزيز العمل الجماعي لأعضاء الهيئات الادارية للاتحادات الرياضية المركزية في العراق
Authors: Dr. Azhar Abid Mohammed  
Published: September 2024

هدفت الدراسة الى التعرف على إدارة الاحتواء وعلاقتها بتعزيز العمل الجماعي لدى أعضاء الهيئات الادارية للاتحادات الرياضية المركزية في العراق، واستخدمت الباحثة المنهج الوصفي بالأَسلوب المسحي والعلاقات الارتباطية، وحددت الباحثة عينة البحث التي تمثلت بأعضاء الهيئات الإدارية للاتحادات الرياضية المركزية في العراق، والبالغ عددهم (347) فرداً موزعين على (49) اتحاد في العراق، ثم قامت الباحثة باتباع كافة الإجراءات العلمية من صدق وثبات وقدرة تميزية واتساق داخلي في( بناء مقياس إدارة الاحتواء), و(اعداد مقياس العمل الجماعي)، والتي نتج منها مقياسا الدراسة بصيغتهما النهائية، إذ احتوى مقياس إدارة الاحتواء على (16) فقرة، وموزع بمجالاته هي (الاندماج الوظيفي, التدريب, التحفيز والمكافئات, دعم تكنلوجيا العمل)، ومقياس العمل الجماعي على (24) فقرة، وموزع بمجالاته هي( التعاون, المحبة, النفسي, الاجتماعي) ,بعد ذلك قامت الباحثة بتطبيق مقياسي الدراسة على عينة التطبيق وإِجراء كافة الوسائل الإِحصائية ذات العلاقة بأهداف ومتغيرات البحث، وكانت اهم استنتاجات البحث هو تمتع الهيئات الإدارية للاتحادات الرياضية المركزية في العراق تمتع الاتحادات الرياضية بحسن إدارة الاحتواء، ممزوجة بروح العمل الجماعي، ووجود علاقة ارتباطية جيدة بين إدارة الاحتواء والعمل الجماعي، التي تساعد على سرعة انجاز كافة المهام الإدارية في الاتحادات الرياضية المركزية في العراق.
تأثير تدريبات أسلوب المربعات الأربعة في بعض القدرات البدنية والمهارية والوظيفية للاعبي مركز اكتشاف اللاعب الموهوب بأعمار 10-12 سنة لكرة القدم
Authors: Prof.Dr.FADHIL DAHAM MANSOUR  , ALI HUSSEIN SAGHEER Asst. Dr  , HUMAM ISMAEL HUSSEIN Dr.  
Published: September 2024

تضمنت مشكلة البحث في وجود إنخفاضاً واضحا في مستوى القدرات البدنية, وخاصة القدرة الانفجارية ، وتحمل الاداء وعدم امتلاك اللاعبين التوافق والتوازن في أداء الحركات والمهارات الأساسية من خلال عدم مقدرة اللاعبين على الأداء القوي, والسريع طوال فترة المباراة فالتدريب بكرة القدم هو لعب يستهدف كافة الإبعاد لذا يسعى الباحثون لحل هذه المشكلة باستعمال أسلوب (المربعات الاربعة), وهدفت الدراسة إلى إعداد برنامج تدريبي بأسلوب المربعات الاربعة لتطوير بعض القدرات البدنية (القدرة الانفجارية ، وتحمل الاداء) والمهارات (المناولة، الدحرجة , التهديف) والمتغيرات الوظيفية (السعة الحيوية والحد الاقصى لاستهلاك الاوكسجين )للاعبي مركز اكتشاف اللاعب الموهوب لكرة القدم بأعمار 10 -12سنة , والتعرّف على تأثير البرنامج التدريبي في المتغيرات المبحوثة, كما إستعمل الباحثون المنهج التجريبي بأسلوب المجموعتين ( التجريبية والضابطة) وتم إجراء الإختبارات القبلية لمتغيرات البحث القدرات البدنية (القدرة الانفجارية ، وتحمل الاداء) المهارات الاساسية (المناولة، والدحرجة) والمتغيرات الوظيفية (السعة الحيوية) وتم تطبيق البرنامج خلال التجربة الرئيسة على المجموعة التجريبية خلال (24), وحدة تدريبية في (8) أسابيع, أي بواقع (3) وحدات تدريبية في الأسبوع , وتم إجراء الإختبارات البعدية لمعرفة التطور الحاصل في متغيرات البحث من خلال الموازنة بين نتائج الإختبارات القبلية, والبعدية, واستنتج الباحثون إنً أسلوب المربعات الاربعة أسهم في تطوير متغيرات البحث ،كما استنج الباحثون ان اسلوب المربعات الاربعة اكثر ملائمة للفئات العمرية الصغيرة(البراعم)
PELATIHAN PEMBUATAN SABUN CUCI CAIR PADA WARGA KAMPUNG BULAK PONDOK MELATI KOTA BEKASI
Authors: Mayarni  , Kartikawati Eka , Murwitaningsih Susanti 
Published: September 2024

The partner's problem is the lack of creativity to start an entrepreneurship. Partners include residents who are dominated by the lower middle economy. The survey results show that the residents work as teachers, office workers, factory workers selling snacks but this is only about five percent of the total local population. Other professions such as washing and scrubbing, traveling vegetable sellers, and construction workers are fewer than those who are unemployed. Furthermore, there are families who have the skills to make snacks such as chips, pecal and fried foods, but there are only about three to five families. This means that the local community, especially housewives, is dominated by unemployed mothers who are supported by their husbands' income, which is dominated by irregular income. This problem has an impact on the disruption of children's schooling, domestic quarrels and even divorce. The solution that will be offered is to increase family income by entrepreneurship through making liquid laundry soap. Making this liquid laundry soap is not too difficult and the raw materials are also easy to obtain. The service method uses training and demonstration. The results of community service activities in making liquid laundry soap are very necessary, this is because it can be used as an alternative side entrepreneurship that is very profitable for the community.
Combining network pharmacology, machine learning, molecular docking and molecular dynamic to explore the mechanism of Chufeng Qingpi decoction in treating schistosomiasis
Authors: Liu Minglu , Wang Yuxin , Deng Wen , Xie Jiahao , He Yanyao , Wang Liang , Zhang Jianbin , Cui Ming 
Published: September 2024

BackgroundAlthough the Chufeng Qingpi Decoction (CQD) has demonstrated clinical effectiveness in the treatment of schistosomiasis, the precise active components and the underlying mechanisms of its therapeutic action remain elusive. To achieve a profound comprehension, we incorporate network pharmacology, bioinformatics analysis, molecular docking, and molecular dynamics simulations as investigative methodologies within our research framework.MethodUtilizing TCMSP and UniProt, we identified formula components and targets. Cytoscape 3.10.0 was used to construct an herb–target interaction network. Genecards, DisGeNET, and OMIM databases were examined for disease-related objectives. A Venn diagram identified the intersection of compound and disease targets. Using Draw Venn, overlapping targets populated STRING for PPI network. CytoNCA identified schistosomiasis treatment targets. GO &amp; KEGG enrichment analysis followed High-scoring genes in PPI were analyzed by LASSO, RF, SVM-RFE. Molecular docking &amp; simulations investigated target-compound interactions.ResultThe component’s target network encompassed 379 nodes, 1629 edges, highlighting compounds such as wogonin, kaempferol, luteolin, and quercetin. Amongst the proteins within the PPI network, PTGS2, TNF, TGFB1, BCL2, TP53, IL10, JUN, MMP2, IL1B, and MYC stood out as the most prevalent entities. GO and KEGG revealed that mainly involved the responses to UV, positive regulation of cell migration and motility. The signal pathways encompassed Pathways in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis, as well as the AGE-RAGE. Bioinformatics analysis indicated TP53 was the core gene. Ultimately, the molecular docking revealed that wogonin, kaempferol, luteolin, and quercetin each exhibited significant affinity in their respective interactions with TP53. Notably, kaempferol exhibited the lowest binding energy, indicating a highly stable interaction with TP53. Lastly, we validated the stability of the binding interaction between the four small molecules and the TP53 through molecular dynamics simulations. The molecular dynamics simulation further validated the strongest binding between TP53 and kaempferol. In essence, our research groundbreaking in its nature elucidates for the first time the underlying molecular mechanism of CQD in the therapeutic management of schistosomiasis, thereby providing valuable insights and guidance for the treatment of this disease.ConclusionThis study uncovered the efficacious components and underlying molecular mechanisms of the Chufeng Qingpi Decoction in the management of schistosomiasis, thereby offering valuable insights for future fundamental research endeavors.
Efficacy of venoarterial extracorporeal membrane oxygenation with and without intra-aortic balloon pump in adult cardiogenic shock
Authors: Wang Haiwang , Li Chuanlong , Li Duo , Chen Yuansen , Li Wenli , Liu Yanqing , Li Yongnan , Fan Haojun , Hou Shike 
Published: September 2024

IntroductionIntra-aortic balloon pump (IABP) is sometimes coupled with Venoarterial extracorporeal membrane oxygenation (VA-ECMO) to treat patients with cardiogenic shock. In this study, we attempted to evaluate the association of the IABP approach on survival and vascular complication rates in adults with cardiogenic shock undergoing VA-ECMO.MethodsWe performed a systematic search of original studies on VA-ECMO with and without IABP in PubMed, EMBASE, and the Cochrane Library.ResultsA total of 42 studies with 8,759 patients were included. The pooled in-hospital deaths of patients on VA-ECMO with and without IABP were 2,962/4,807 (61.61%) versus 2,666/3,952 (67.45%). VA-ECMO with IABP presents lower in-hospital mortality (risk ratio, 0.88; 95% CI, 0.86-0.91; P &lt; 0.00001). In addition, IABP was associated with lower in-hospital mortality of patients with postcardiotomy cardiogenic shock and ischaemic heart disease. (risk ratio, 0.93; 95% CI, 0.87–0.98; P = 0.01; risk ratio, 0.85; 95% CI, 0.82–0.89; P &lt; 0.00001). There was no significant difference in in-hospital morbidity in neurological, gastrointestinal, limb-related, bleeding, and infection complications between patients on VA-ECMO with and without IABP.DiscussionIn these observational studies, concomitant use of IABP and VA-ECMO in adult patients with cardiogenic shock was associated with reduced in-hospital mortality.Systematic Review RegistrationPROSPERO [CRD42017069259].
Non-functional alpha-cell hyperplasia with glucagon-producing NET: a case report
Authors: Cidade-Rodrigues Catarina , Santos Ana Paula , Calheiros Raquel , Santos Sara , Matos Catarina , Moreira Ana Paula , Inácio Isabel , Souteiro Pedro , Oliveira Joana , Jácome Manuel , Pereira Sofia S. , Henrique Rui , Torres Isabel , Monteiro Mariana P. 
Published: September 2024

IntroductionAlpha-cell hyperplasia (ACH) is a rare pancreatic endocrine condition. Three types of ACH have been described: functional or nonglucagonoma hyperglucagonemic glucagonoma syndrome, reactive or secondary to defective glucagon signaling, and non-functional. Few cases of ACH with concomitant pancreatic neuroendocrine tumors (pNETs) have been reported and its etiology remains poorly understood. A case report of non-functional ACH with glucagon-producing NET is herein presented.Case reportA 72-year-old male was referred to our institution for a 2 cm single pNET incidentally found during imaging for acute cholecystitis. The patient’s past medical history included type 2 diabetes (T2D) diagnosed 12 years earlier, for which he was prescribed metformin, dapagliflozin, and semaglutide. The pNET was clinically and biochemically non-functioning, apart from mildly elevated glucagon 217 pg/ml (&lt;209), and 68Ga-SSTR PET/CT positive uptake was only found at the pancreatic tail (SUVmax 11.45). The patient underwent a caudal pancreatectomy and the post-operative 68Ga-SSTR PET/CT was negative. A multifocal well-differentiated NET G1, pT1N0M0R0 (mf) strongly staining for glucagon on a background neuroendocrine alpha-cell hyperplasia with some degree of acinar fibrosis was identified on pathology analysis.Discussion and conclusionThis case reports the incidental finding of a clinically non-functioning pNET in a patient with T2D and elevated glucagon levels, unexpectedly diagnosed as glucagon-producing NET and ACH. A high level of suspicion was required to conduct the glucagon immunostaining, which is not part of the pathology routine for a clinically non-functioning pNET, and was key for the diagnosis that otherwise would have been missed. This case highlights the need to consider the diagnosis of glucagon-producing pNET on an ACH background even in the absence of glucagonoma syndrome.
Survival prediction in peritoneal mesothelioma: a nomogram based on SEER data and a Chinese cohort
Authors: Fang Yuting , Xiang Midan , Jiang Zhichao , Li Hongrui , Yuan Guangwen , Pei Wei , Li Wenbin , Sun Yongkun 
Published: September 2024

ObjectiveThis study aimed to develop nomogram predicting overall survival (OS) of patients with peritoneal mesothelioma (PeM) using data from Surveillance, Epidemiology, and End Results (SEER) database and a Chinese institution.Methods1,177 PeM patients from the SEER database were randomized into training and internal validation cohorts at a 7:3 ratio. An external validation cohort consisting of 109 patients was enrolled from a Chinese institution. Nomogram was constructed based on variables identified through multivariate Cox regression analysis and evaluated by consistency indices (C-index), calibration plots, and receiver operating characteristic (ROC) curves. Patients were stratified into different risk categories, and Kaplan-Meier survival analysis was used to assess OS differences among these groups.ResultsThe nomogram, incorporating age, gender, histological type, T stage, M stage, and surgical status, demonstrated strong predictive capability with C-index values of 0.669 for the training cohort, 0.668 for the internal validation cohort, and 0.646 for the external validation cohort. The nomogram effectively stratified patients into high-risk and low-risk groups, with the high-risk group exhibiting significantly poorer OS (P &lt; 0.05). Multivariate analysis confirmed gender, age, surgical intervention, and M stage as independent prognostic factors (P &lt; 0.05). Specifically, male gender, older age, and unspecified M stage were linked to worse outcomes, while surgical intervention was associated with improved survival.ConclusionThe nomogram provide a reliable tool for predicting the survival in PeM patients, facilitating more informed treatment decisions. Key independent prognostic factors include gender, age, surgical intervention, and M stage.
Discovery of ferroptosis-related genes in renal ischemia reperfusion and evaluate the potential impact on kidney transplantation
Authors: Zhou Yao , Yang Yuwei , Wang Bo , Chen Wan , Wei Yanlin , Wu Ruihua , Meng LingZhang , Lyu Liwen 
Published: September 2024

BackgroundRenal ischemia reperfusion injury (IRI) is one of the pivotal event of acute kidney injury (AKI), and they are unavoidable in the process of kidney transplantation, which eventually leads to the loss of renal allograft. Ferroptosis is a newly identified programmed cell death. Recent studies have suggested that ferroptosis may participate in the pathophysiological process of renal IRI. Therefore, we aimed to determine biomarkers associated with ferroptosis during renal IRI and their impact on renal allografts.MethodsWe conducted a comprehensive bioinformatics analysis and established an IRI-AKI animal model to illustrate the critical role of ferroptosis-related hub genes (FRHGs) in IRI-AKI and their potential impact on kidney transplantation.ResultsIn this study, we identified 60 ferroptosis-related genes (FRGs) in renal IRI based on the GSE148420 dataset and FerrDb database. And then we performed functional annotation analysis using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Protein-protein interaction (PPI) network was constructed by online tool String. EZH2, CDKN1A, PPARA, EGR1, ATF3, and CD44 were identited as six ferroptosis-related hubgenes (FRHGs) using four methods, including MMC, Degree, DMNC, and EPC. FRHGs expression level were verified by the validation sets GSE58438 and GSE126805. Protein expression level of FRHGs verified by Proteomics and Western blot. Cibersort was utilized to analyze immune cell infiltration during renal IRI as well as the correlation between FRHGs and immune cells. The GSE21374 dataset was used for renal allografts survival analysis. Finally, We induced the IRI-AKI animal model and illustrated the importance of FRGHs CD44 in ferroptosis and the accumulation of macrophages.ConclusionWe identified 6 FRHGs. We found that FRHGs not only exhibited significant correlation with immune cells but also directly influenced the survival of transplanted kidneys in the human population. Among six FRHGs, only CD44 was overexpressed at both the gene and protein levels. Anti-CD44 exerts a protective effect by inhibiting ferroptosis and the accumulation of M1 macrophages during renal IRI. This study provided new insights into the pathogenesis of renal IRI and provided new evidence for its treatment.
Computational recognition of regulator genes and signature for ferroptosis with implications on immunological properties and clinical management of atopic dermatitis
Authors: Xu Lei , Guo Wenjuan , Hao Huirong , Yuan Jinping , Bai Bingxue 
Published: September 2024

BackgroundAtopic dermatitis (AD) is a common chronic dermatitis of autoimmune origin that considerably affects the quality of life of patients. Ferroptosis, a newly regulated form of cell death, is essential for inflammation-related damage-associated molecular patterns (DAMPs). In this study, we aimed to identify ferroptosis regulators relevant to AD pathogenesis and reveal the mechanisms by which ferroptosis regulates the pathogenesis of AD.MethodsWe analyzed the GEO AD cohorts (GSE16161, GSE32924, GSE107361, and GSE120721), identifying AD-related differentially expressed genes (DEGs) using edgeR. Co-expression and STRING database analyses were used to elucidate the interactions between DEGs and ferroptosis markers. Through functional enrichment analysis, we defined potential biological functions within the protein-protein interaction (PPI) network and developed FerrSig using LASSO regression. The utility of FerrSig in guiding the clinical management of AD was evaluated using the GSE32473 cohort. Subsequently, our in silico findings were confirmed, and mechanistic insights were expanded through both in vitro and in vivo studies, validating the relevance of FerrSig.ResultsIn the GEO AD cohort, 278 DEGs were identified, including seven ferroptosis signature genes. Co-expression analysis and STRING database review revealed a 63-node PPI network linked to cell cycle and pro-inflammatory pathways. Four ferroptosis genes (ALOXE3, FABP4, MAP3K14, and EGR1) were selected to create FerrSig, which was significantly downregulated in samples collected from patients with AD. In addition, immune-related signaling pathways were significantly differentially enriched between the stratifications of samples collected from patients with AD with high and low ferritin levels, whereas in the GSE32473 cohort, FerrSig was significantly increased in cohorts effectively treated with pimecrolimus or betamethasone. Finally, in vitro and in vivo models showed a notable FerrSig decrease in patients with AD versus healthy control. Treatment with betamethasone and tacrolimus restored FerrSig, and the magnitude of the increase in FerrSig was higher in samples collected from patients with AD with better efficacy assessments. In addition, FerrSig was significantly positively correlated with the ferroptosis inhibitors GPX4 and SLC7A11 and negatively correlated with reactive oxygen species (ROS) levels and p-STAT3/STAT3. This implies that the FerrSig signature genes may regulate ferroptosis through the JAK/STAT3 signaling pathway.ConclusionOur study further explored the pathogenesis of AD, and FerrSig could serve as a potential biomarker for identifying AD morbidity risks and determining treatment efficacy.
Nomogram using human epididymis protein 4 predicted concurrent endometrial cancer from endometrial atypical hyperplasia before surgery
Authors: Lou Yaochen , Jiang Feng , Du Yan , Guan Jun 
Published: September 2024

ObjectiveTo establish a nomogram based on presurgical predictors of concurrent endometrial cancer (EC) for patients diagnosed with endometrial atypical hyperplasia before definitive surgery (preoperative-EAH) to improve the risk stratification and clinical application.MethodsPreoperative-EAH patients who underwent hysterectomy in a tertiary hospital from January 2020 to December 2022 were retrospectively analyzed. Independent predictors from the multivariate logistic regression model were used to establish a nomogram, and bootstrap resampling was used for internal validation.ResultsOf 370 preoperative-EAH patients, 23.4% were diagnosed with EC after definitive surgery (final-EC). Multivariate analyses found three independent predictors of final EC: human epididymis protein 4 (HE4) ≥43.50 pmol/L [odds ratio (OR) = 3.70; 95% confidence intervals (CI) = 2.06–6.67], body mass index (BMI) ≥ 28 kg/m2 (OR = 2.05; 95% CI = 1.14–3.69), and postmenopausal status, particularly at postmenopausal time ≥5 years (OR = 5.84, 95% CI = 2.51–13.55), which were used to establish a nomogram model. The bootstrap-corrected C-index of the nomogram was 0.733 (95% CI = 0.68–0.79), which was significantly higher than that of each individual factor. The calibration curve and decision curve showed good consistency and clinical net benefit of the model. At the maximum Youden index, 49.4% (43/87) of women in the high-risk group defined by nomogram had concurrent EC, versus 16.6% in the low-risk group (P&lt; 0.001).ConclusionThe nomogram based on HE4, menopausal status, and BMI was found with an improved predictive value to stratify preoperative-EAH patients at high risk of concurrent EC for better clinical management.
Topical treatment of chemotherapy-induced peripheral neuropathy (CIPN) with high-concentration (179 mg) capsaicin patch in breast cancer patients – results of the QUCIP study
Authors: Lux Michael Patrick , Flöther Lilit , Frömter Catrin , Rack Brigitte , Veselinovic Kristina , Heine Myriam , Paepke Stefan , Krabisch Petra , Quandel Tamara , Sabatowski Rainer 
Published: September 2024

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) following oral or intravenous chemotherapy often results in neuropathic pain, accompanied by symptoms such tingling, burning and hypersensitivity to stimuli, with a notable decline in quality of life (QoL). Effective therapies for CIPN are lacking, with a high demand for analgesics to address this issue. The QUCIP study aimed to assess the effectiveness of high concentration (179 mg) capsaicin patch (HCCP) in alleviating neuropathic pain and associated symptoms in breast cancer patients with confirmed CIPN.MethodsQUCIP is a prospective, multi-center observational study spanning 36 weeks with up to three HCCP treatments. Initial treatment (visit V0) was followed by two telephone contacts (T1, T2) and subsequent face-to-face visits every 12 weeks or upon retreatment (visits V1–V3). 73 female patients with painful CIPN post neoadjuvant/adjuvant breast cancer therapy were enrolled. Primary endpoint was the reduction of neuropathic pain symptom score (painDETECT®). Secondary endpoints included improvements in CIPN-specific QoL (QLQ-CIPN20), reductions in pain intensity (numeric pain rating scale, NPRS), and achievement of ≥ 30% and ≥ 50% pain reduction.ResultsMedian age was 61 years, with 52.0% of patients experiencing peripheral neuropathic pain for &gt; 1 year (&gt; 2 years: 34.2%). The painDETECT® score significantly decreased from baseline (19.71 ± 4.69) to 15.80 ± 6.20 after initial treatment (p &lt; 0.0001) and continued to decrease at follow-up visits. The NPRS indicated significant pain intensity reduction at each time point, particularly pronounced in patients receiving three HCCP treatments. Clinically significant pain relief of ≥ 30% increased from 25.0% at week 4 (T2) to 36.2%, 43.5%, and 40.0% at weeks 12 (V1), 24 (V2), and 36 (V3), respectively. The percentage of patients achieving pain relief of ≥ 50% increased from 14.7% at T2 to 15.5%, 21.7% and 32.5% at V1, V2 and V3, respectively. Patients further reported a significant improvement in their CIPN-related QoL throughout the study. Adverse drug reactions (ADRs) mainly included application site reactions.ConclusionIn this study, HCCP shows benefit in managing CIPN in real-world settings. The data demonstrate a sustained and progressive reduction in neuropathic pain and symptomatology, confirming the clinical benefit of repeated treatment observed in former clinical trials. HCCP treatment has also the potential to significantly improve the QoL associated with CIPN. The safety profile of HCCP was confirmed, supporting its use in clinical practice.