bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival benefit of liver resection for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma
Authors: Kim H , Ahn S W , Hong S K , Yoon K C , Kim H-S , Choi Y R , Lee H W , Yi N-J , Lee K-W , Suh K-S 
Published: May 2017

Abstract

Background
Although transarterial chemoembolization is recommended as the standard treatment for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma (BCLC-B HCC), other treatments including liver resection have been used. This study aimed to determine the survival benefit of treatment strategies including resection for BCLC-B HCC compared with non-surgical treatments.

Methods
The nationwide multicentre database of the Korean Liver Cancer Association was reviewed. Patients with BCLC-B HCC who underwent liver resection as a first or second treatment within 2 years of diagnosis and patients who received non-surgical treatment were selected randomly. Survival outcomes of propensity score-matched groups were compared.

Results
Among 887 randomly selected patients with BCLC-B HCC, 83 underwent liver resection as first or second treatment and 597 had non-surgical treatment. After propensity score matching, the two groups were well balanced (80 patients in each group). Overall median survival in the resection group was better than that for patients receiving non-surgical treatment (50·9 versus 22·1 months respectively; P &lt; 0·001). The 1-, 2-, 3- and 5-year overall survival rates in the resection group were 90, 88, 75 and 63 per cent, compared with 79, 48, 35 and 22 per cent in the no-surgery group (P &lt; 0·001). In multivariable analysis, non-surgical treatment only (hazard ratio (HR) 3·35, 95 per cent c.i. 2·16 to 5·19; P &lt; 0·001), albumin level below 3·5 g/dl (HR 1·96, 1·22 to 3·15; P = 0·005) and largest tumour size greater than 5·0 cm (HR 1·81, 1·20 to 2·75; P = 0·005) were independent predictors of worse overall survival.

Conclusion
Treatment strategies that include liver resection offer a survival benefit compared with non-surgical treatments for potentially resectable BCLC-B HCC.
Steam reforming of tar model compounds over ni supported on CeO2and mayenite
Authors: de Caprariis Benedetta , Bracciale Maria Paola , De Filippis Paolo , Hernandez Asbel David , Petrullo Antonietta , Scarsella Marco 
Published: May 2017

AbstractNi‐CeO2, Ni/Co‐CeO2, and Ni‐Ca12Al14O33were synthesized by the auto‐combustion method and tested as catalysts in the steam reforming of tar model compounds in a fixed bed reactor. Toluene, phenol, andn‐heptane were chosen as representative of the different classes of organic compounds that can be found in tar. The catalysts were characterized by X‐ray diffraction (XRD) and temperature‐programmed reduction (TPR). From XRD analysis it was observed in all the synthesized catalysts the presence of two phases, NiO and CeO2or Ca12Al14O33. A stronger interaction of NiO with mayenite structure, compared to that of NiO with CeO2, was also shown by TPR analysis. The best performances in terms of conversion and stability were obtained when Ni supported on mayenite was used, confirming the higher redox properties of this support that confers to the catalyst a better resistance to deactivation by carbon deposition. The lower performances observed for Ni supported on CeO2in terms of conversion and activity were substantially improved by partial substitution of Ni with Co, confirming its ability to increase the Ni catalytic activity and to enhance the reforming of oxygenated species. The apparent kinetic parameters calculated for all the catalysts and the model compounds confirm the obtained experimental results.
Carbon‐Free O2 Cathode with Three‐Dimensional Ultralight Nickel Foam‐Supported Ruthenium Electrocatalysts for Li–O2 Batteries
Authors: Liu Ziqiang , Feng Ningning , Shen Zihan , Li Fujun , He Ping , Zhang Huigang , Zhou Haoshen 
Published: May 2017

AbstractA new carbon‐ and binder‐free O2 cathode was fabricated by electroplating Ru‐nanoparticle‐coated ultralight Ni foam, which has good electron‐conducting and electrocatalytic properties. This all‐metal monolithic structure was able to suppress CO2 evolution and provided 306 times higher capacity than commercial Ni foam‐based O2 cathodes.
High Photon‐to‐Current Conversion in Solar Cells Based on Light‐Absorbing Silver Bismuth Iodide
Authors: Zhu Huimin , Pan Mingao , Johansson Malin B. , Johansson Erik M. J. 
Published: May 2017

AbstractHere, a lead‐free silver bismuth iodide (AgI/BiI3) with a crystal structure with space group R
m is investigated for use in solar cells. Devices based on the silver bismuth iodide deposited from solution on top of TiO2 and the conducting polymer poly(3‐hexylthiophene‐2,5‐diyl) (P3HT) as a hole‐transport layer are prepared and the photovoltaic performance is very promising with a power conversion efficiency over 2 %, which is higher than the performance of previously reported bismuth‐halide materials for solar cells. Photocurrent generation is observed between 350 and 700 nm, and the maximum external quantum efficiency is around 45 %. The results are compared to solar cells based on the previously reported material AgBi2I7, and we observe a clearly higher performance for the devices with the new silver and bismuth iodides composition and different crystal structure. The X‐ray diffraction spectrum of the most efficient silver bismuth iodide material shows a hexagonal crystal structure with space group R
m, and from the light absorption spectrum we obtain an indirect band gap energy of 1.62 eV and a direct band gap energy of 1.85 eV. This report shows the possibility for finding new structures of metal‐halides efficient in solar cells and points out new directions for further exploration of lead‐free metal‐halide solar cells.
Incidence and significance of true papillae in thyroid fine needle aspiration*
Authors: Renshaw Andrew A. , Gould Edwin W. 
Published: May 2017

AbstractIntroductionWhether true papillae without nuclear features of papillary carcinoma in thyroid fine needle aspirates should be diagnosed as atypia of undetermined significance (AUS) is unclear.MethodsThe results of all thyroid FNAs performed from 2014‐2016 with corresponding resections as well as aspirates from 2000‐2016 with a diagnosis of follicular variant of papillary carcinoma or Noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) were reviewed.ResultsPapillae with fibrovascular cores were identified in 17 of 149 consecutive cases (11%), 3 of which had nuclear features of papillary carcinoma and were papillary carcinoma at resection. All 14 cases of papillae without nuclear features of papillary carcinoma were benign. Of 29 papillary carcinomas, papillae were identified in 8 (28%) and “swirls” were identified in 3 (10%) additional cases, all in cases of papillary carcinoma, NOS. Papillae and swirls were not identified in any cases of NIFTP (13 cases) or follicular variants of papillary carcinoma (15 cases).ConclusionTrue papillae are relatively common. Both papillae with nuclear atypia and swirls are highly specific for papillary carcinoma, NOS and are not seen in NIFTP. True papillae with fibrovascular cores but without cytologic features of papillary carcinoma are benign and should not be diagnosed as AUS. Diagn. Cytopathol. 2017;45:689–692. © 2017 Wiley Periodicals, Inc.
Costly defense in a fluctuating environment—sensitivity of annual Nothobranchius fishes to predator kairomones
Authors: Polačik Matej , Janáč Michal 
Published: May 2017

AbstractAntipredator strategies increase the chances of survival of prey species but are subject to trade‐offs and always come at a cost, one specific category being the “missed opportunity.” Some animals that can modulate the timing of life‐cycle events can also desynchronize this timing with the occurrence of a predator. In an unpredictable environment, such a modification may result in a mismatch with prevailing conditions, consequently leading to reproductive failure. In eastern Africa, temporary pools existing only during the rainy season are inhabited by annual fish of the genus Nothobranchius. We examined (i) the capability of multiple Nothobranchius populations and species to cease hatching when exposed to chemical cues from native fish predators and adult conspecifics and (ii) the ability of N. furzeri to modulate their growth rate in the presence of a gape‐limited fish predator. As the tested Nothobranchius spp. originate from regions with extreme environmental fluctuations where the cost of a missed opportunity can be serious, we predicted an inability to cease hatching as well as lack of growth acceleration as both the predator's gape limitation and the environment select for the same adaptation. Our results showed no biologically relevant influence of kairomone on hatching and no influence on growth rate. This suggests that, in an unpredictable environment, the costs of a missed opportunity are substantial enough to prevent the evolution of some antipredator defense strategies.
Selective Electrochemical Detection of Pirarubicin by Means of DNA‐modified Graphite Biosensor
Authors: Paziewska−Nowak Agnieszka , Jankowska−Śliwińska Joanna , Dawgul Marek , Pijanowska Dorota G. 
Published: May 2017

AbstractPirarubicin (THP) is an anthracycline drug, which is mainly used in the anticancer treatment. Utilization of THP may be associated with many dangerous side effects, therefore monitoring of drug level in patients’ organism is an important aspect of chemotherapy. In our research we focused on designing of an electrochemical DNA‐based biosensor for selective detection of pirarubicin (THP). Our biosensor utilizes the ability of pirarubicin to interact with DNA double helix and the fact that THP is an electrochemically active compound. Graphite electrodes modified with DNA enable to obtain nearly three thousand times higher sensitivity (41.8⋅103 A/M) than non‐modified sensors. Furthermore, in the case of THP detection by means of bare graphite electrodes, LOD was 43.6⋅10−9 M, whereas for developed DNA biosensors ‐112⋅10‐12 M. A study of selectivity of DNA–modified biosensors was carried out in aqueous solutions containing interferents: acetaminophen (PCT) and ascorbic acid (AA) as well as in samples of fetal bovine serum (FBS) spiked with PCT and AA. In established measurement conditions one peak corresponding to THP reduction was observed, whereas no redox peaks assigned to interferents (PCT, AA) were present. These results indicate that developed biosensors are selective to pirarubicin.
Reconciled Nanoarchitecture with Overlapped 2 D Anatomy for High‐Energy Hybrid Supercapacitors
Authors: Abureden Salah , Hassan Fathy M. , Yu Aiping , Chen Zhongwei 
Published: May 2017

AbstractA unique and novel, flower bouquet‐like, vanadium disulfide (VS2) nanosheet structure with very small prominent VS2 nanoparticles (10–25 nm) anchored on the surface of graphene nanosheets (VS2/G) was synthesized by a facile solvothermal method. The material showed superior electrochemical performance upon testing as a supercapacitor and achieved specific capacitance values of 211 and 135 F g−1 at current densities of 1 and 20 A g−1, respectively, with 97 % capacitance retention after 8000 cycles at 5 A g−1 with high coulombic efficiency. The material was used to fabricate a full‐cell hybrid supercapacitor (HSC), which showed a specific capacitance of 132 F g−1 at a current density of 1 A g−1 with remarkable cyclability up to 8000 cycles at 5 A g−1 and a loss of less than 1×10−4 F cycle−1. The HSC demonstrated an excellent energy density of 46.93 Wh kg−1 at a power density of 0.91 kW kg−1 and retained a high energy density of 23.11 Wh kg−1 even upon increasing the power density tenfold (9.40 kW kg−1). This unique material synthesized by a simple method is a very promising candidate for next‐generation energy‐storage technologies that can fill the gap between batteries and supercapacitor devices.
Application of high‐resolution Mobile Metal Ion (MMI) soil geochemistry to archaeological investigations: An example from a Roman metal working site, Somerset, United Kingdom
Authors: Sylvester Graham C. , Mann Alan W. , Rate Andrew W. , Wilson Clare A. 
Published: May 2017

AbstractAn innovative application of Mobile Metal Ion (MMI) partial extraction soil geochemistry is used to identify below‐surface archaeological features, using a previously incompletely surveyed Roman metal‐working site at St. Algar's Farm, Somerset, as a case study. Soil samples were taken and analyzed for 53 elements by the MMI geochemical method. Lead, Tl, Ba, and Zn were found in very high concentrations and the sensitivity of the technique also enabled Ag, Au, and Sn to be measured in anomalous concentrations. Elemental maps accurately outlined known metal working areas. Principal component analysis and bivariate correlations identified two suites of associated elements: Pb, Ba, Tl, Ag, Au, Cu, Sb, the base and noble metal group (BNM), and Fe, Ti, Nb, Mn, Co, Cu, P, Li, Rb, Sc, Cs, K, Ga, P, Zr, Th, and Sn, the pegmatite (PEG) group. These were used to form indices that delineate the metal working area and areas possibly related to the processing of pegmatite containing Sn. The high‐sensitivity MMI data were compared with strong acid digest results from a limited number of the MMI samples; the MMI data showed better geochemical contrast than the strong acid results. Multielement statistical similarity comparisons with off‐site samples suggest likely sources for the Pb and Sn used at the St. Algar's site. The increased sensitivity of MMI soil analysis combined with the multielement capacity allows a more detailed archaeological interpretation.
Gravity and the formation of the archaeological record: Main concepts and methodological tools
Authors: Ozán Ivana L. 
Published: May 2017

AbstractThis contribution aims to discuss how gravity‐driven processes affect the archaeological record with the goal of building a broad conceptual and methodological framework for dealing with these contexts. A wide compilation of cases regarding gravity‐driven processes is analyzed to recognize relevant environmental factors, the way they affect the properties of the record, and long‐term archaeological expectations. Only by understanding the specific mechanisms and processes that occur in each context can an accurate methodological approach be chosen on which to base interpretations. A careful taphonomic study of the spatial distribution, frequency, size, diversity, and orientation of materials comprising the archaeological record is the first step to recognizing formation processes. Actualistic studies provide a framework for discussing the timing and intensity at which processes occur. A detailed geomorphological description is required to interpret sedimentological and micromorphological analysis, which in turn helps understanding of the relative subaerial permanence of the record, its temporal resolution, and preservation potential. Interpreting surface and buried materials requires the understanding of pedogenetic processes. Broad in/off‐site spatial sampling strategies definitely yield a more realistic picture about the variety of processes in slope settings.
Injectable dual redox responsive diselenide‐containing poly(ethylene glycol) hydrogel
Authors: Gong Chu , Shan Meng , Li Bingqiang , Wu Guolin 
Published: May 2017

AbstractAn injectable dual redox responsive diselenide‐containing poly(ethylene glycol) (PEG) hydrogel was successfully developed by combining the conceptions of injectable hydrogels and dual redox responsive diselenides. In the first step, four‐armed PEG was modified with N‐hydroxysuccinimide (NHS)‐activated esters and thereafter, crosslinked by selenocystamine crosslinkers to form injectable hydrogels via the rapid reaction between NHS‐activated esters and amino groups. The cross‐sectional morphology, mechanical properties, and crosslinking modes of hydrogels were well characterized via scanning electron microscope (SEM), rheological measurements, and Fourier transform infrared spectra, respectively. In addition, the oxidation‐ and reduction‐responsive degradation behaviors of hydrogels were observed and analyzed. The model drug, rhodamine B, was encapsulated in the hydrogel. The drug‐loaded hydrogel exhibited a dual redox responsive release profile, which was consistent with the degradation experiments. The results of all experiments indicated that the formulated injectable dual redox responsive diselenide‐containing PEG hydrogel can have potential applications in various biomedical fields such as drug delivery and stimuli‐responsive drug release. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2451–2460, 2017.
Enhanced chondrogenic differentiation of stem cells using an optimized electrospun nanofibrous PLLA/PEG scaffolds loaded with glucosamine
Authors: Mirzaei Samaneh , Karkhaneh Akbar , Soleimani Masoud , Ardeshirylajimi Abdolreza , Seyyed Zonouzi Hasti , Hanaee‐Ahvaz Hana 
Published: May 2017

AbstractRecently, tissue engineering has become one of the most important approaches in medical research for the treatment of injuries and lesions. In the present study, poly(l‐lactide) acid (PLLA), and polyethylene glycol (PEG) with different ratios and PEG molecular weights were used in order to produce appropriate nanofibrous scaffolds using the electrospinning technique for cartilage tissue engineering applications. Glucosamine was also incorporated into the polymeric scaffolds to enhance the biological properties. Mesenchymal stem cells and chondrocytes were used to monitor the differentiation yield. Water absorption test, 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay, real‐time reverse transcription polymerase chain reaction and mechanical properties analyses were performed to characterize the prepared scaffolds. All fabricated scaffolds had porous and nanofibrous structure with interconnected pores. The PLLA‐PEG scaffolds containing PEG with the molecular weights of 3000 and 20,000 and ratio of 85:15 was selected for glucosamine incorporation and cell culture studies due to their superior mechanical properties. According to our data, it was identified that PLLA/PEG 20,000 containing glucosamine had the most capability to support protein absorption, stem cell attachment, and proliferation. Chondrogenic‐related genes such as sex‐determining region Y‐Box 9 (SOX9) and collagen type II were shown to be expressed on these scaffolds higher than those observed on control groups. Taking together, it was demonstrated that in combination with PLLA, PEG 20,000 is a suitable substrate to improve the mechanical and physical properties of nanofibrous scaffolds. In addition, glucosamine‐PLLA/PEG 20,000 was shown to support stem cell attachment, proliferation, and chondrogenic differentiation and so holds promising potential for cartilage tissue engineering applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2461–2474, 2017.
Characterization of wear debris from metal‐on‐metal hip implants during normal wear versus edge‐loading conditions
Authors: Kovochich Michael , Fung Ernest S. , Donovan Ellen , Unice Kenneth M. , Paustenbach Dennis J. , Finley Brent L. 
Published: May 2017

AbstractAdvantages of second‐generation metal‐on‐metal (MoM) hip implants include low volumetric wear rates and the release of nanosized wear particles that are chemically inert and readily cleared from local tissue. In some patients, edge loading conditions occur, which result in higher volumetric wear. The objective of this study was to characterize the size, morphology, and chemistry of wear particles released from MoM hip implants during normal (40° angle) and edge‐loading (65° angle with microseparation) conditions. The mean primary particle size by volume under normal wear was 35 nm (range: 9–152 nm) compared with 95 nm (range: 6–573 nm) under edge‐loading conditions. Hydrodynamic diameter analysis by volume showed that particles from normal wear were in the nano‐ (<100 nm) to submicron (<1000 nm) size range, whereas edge‐loading conditions generated particles that ranged from <100 nm up to 3000–6000 nm in size. Particles isolated from normal wear were primarily chromium (98.5%) and round to oval in shape. Edge‐loading conditions generated more elongated particles (4.5%) (aspect ratio ≥ 2.5) and more CoCr alloy particles (9.3%) compared with normal wear conditions (1.3% CoCr particles). By total mass, edge‐loading particles contained approximately 640‐fold more cobalt than normal wear particles. Our findings suggest that high wear conditions are a potential risk factor for adverse local tissue effects in MoM patients who experience edge loading. This study is the first to characterize both the physical and chemical characteristics of MoM wear particles collected under normal and edge‐loading conditions. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 986–996, 2018.
Corrosion behavior of surface modifications on titanium dental implant. In situ bacteria monitoring by electrochemical techniques
Authors: Díaz Ivan , Pacha‐Olivenza Miguel Ángel , Tejero Ricardo , Anitua Eduardo , González‐Martín Maria Luisa , Escudero Maria Lorenza , García‐Alonso Maria Cristina 
Published: May 2017

AbstractThe effects of surface modifications and bacteria on the corrosion behavior of titanium have been studied. Five surface modifications were analyzed: two acid etchings (op V, op N), acid etching + anodic oxidation (op NT), sandblasting + acid etching (SLA), and machined surfaces (mach). The corrosion behavior of the surface modifications was evaluated by following the standard ANSI/AAMI/ISO 10993‐15:2000. Cyclic potentiodynamic and potentiostatic anodic polarization tests and ion release by ICP‐OES after immersion for 7 days in 0.9% NaCl were carried out. Microbiologically induced corrosion (MIC) of low and high roughness (mach, op V) was assessed in situ by electrochemical techniques. Streptococcus mutans bacteria were resuspended in PBS at a concentration of 3 × 108 bacteria mL−1 and maintained at 37°C. MIC was measured through the open circuit potential, Eoc, and electrochemical impedance spectroscopy from 2 to 28 days. Potentiodynamic curves showed the typical passive behavior for all the surface modifications. The titanium ion release after immersion was below 3 ppb. In situ bacteria monitoring showed the decrease in Eoc from −0.065 (SD 0.067) Vvs. Ag/AgCl in mach and −0.115 (SD 0.084) Vvs. Ag/AgCl in op V, to −0.333 (SD 0.147) Vvs. Ag/AgCl in mach and −0.263 (SD 0.005) Vvs. Ag/AgCl in op V, after 2 and 28 days, respectively. A reduction of the oxide film resistance, especially in op V (54 MΩ cm2 and 6 MΩ cm2, after 2 and 28 days, respectively) could be seen. Streptococcus mutans negatively affected the corrosion resistance of titanium. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 997–1009, 2018.