bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Patient Factors and Outcome of Synthetic Cartilage Implant Hemiarthroplasty vs First Metatarsophalangeal Joint Arthrodesis in Advanced Hallux Rigidus
Authors: Goldberg Andy , Singh Dishan , Glazebrook Mark , Blundell Chris M. , De Vries Gwyneth , Le Ian L. D. , Nielsen Dominic , Pedersen M. Elizabeth , Sakellariou Anthony , Solan Matthew , Younger Alastair S. E. , Daniels Timothy R. , Baumhauer Judith F. ,   on behalf of the Cartiva MOTION Study Group
Published: August 2017

Background: We evaluated data from a clinical trial of first metatarsophalangeal joint (MTPJ1) implant hemiarthroplasty and arthrodesis to determine the association between patient factors and clinical outcomes. Methods: Patients ≥18 years with hallux rigidus grade 2, 3, or 4 were treated with synthetic cartilage implant MTPJ1 hemiarthroplasty or arthrodesis. Pain visual analog scale (VAS), Foot and Ankle Ability Measure (FAAM) sports and activities of daily living (ADL) scores, and Short Form-36 Physical Function (SF-36 PF) subscore were obtained preoperatively, and at 2, 6, 12, 24, 52, and 104 weeks postoperatively. Final outcome data, great toe active dorsiflexion motion, secondary procedures, radiographs, and safety parameters were evaluated for 129 implant hemiarthroplasties and 47 arthrodeses. The composite primary endpoint criteria for clinical success included VAS pain reduction ≥30%, maintenance/improvement in function, no radiographic complications, and no secondary surgical intervention at 24 months. Predictor variables included hallux rigidus grade; gender; age; body mass index (BMI); symptom duration; prior MTPJ1 surgery; preoperative hallux valgus angle, range of motion (ROM), and pain. Two-sided Fisher exact test was used ( P < .05). Results: Patient demographics and baseline outcome measures were similar. Success rates between implant MTPJ1 hemiarthroplasty and arthrodesis were similar ( P > .05) when stratified by hallux rigidus grade, gender, age, BMI, symptom duration, prior MTPJ1 surgery status, and preoperative VAS pain, hallux valgus, and ROM. Conclusion: Synthetic cartilage implant hemiarthroplasty was appropriate for patients with grade 2, 3, or 4 hallux rigidus. Its results in those with associated mild hallux valgus (≤20 degrees) or substantial preoperative stiffness were equivalent to MTPJ1 fusion, irrespective of gender, age, BMI, hallux rigidus grade, preoperative pain or symptom duration. Level of Evidence: Level II, randomized clinical trial.
Positive impact of cladribine on quality of life in people with relapsing multiple sclerosis
Authors: Afolabi Dayo , Albor Christo , Zalewski Lukasz , Altmann Dan R , Baker David , Schmierer Klaus 
Published: August 2017

Background: A number of elements of the pivotal ‘cladribine tablets treating multiple sclerosis orally’ (CLARITY) trial have remained unpublished. Objective: To report the impact of cladribine on health-related quality of life (QoL) in people with relapsing multiple sclerosis (pwRMS). Methods: QoL data from the phase III trial of two different doses (3.5 and 5.25 mg/kg) of oral cladribine in pwRMS were acquired from the European Medicines Agency through Freedom of Information. Spearman’s rank correlation was used to analyse the relationship between baseline QoL scores and baseline Expanded Disability Status Scale (EDSS) scores. Responses of the Euro Quality of Life 5 Dimensions (EQ-5D) and Multiple Sclerosis Quality of Life-54 (MSQOL-54) questionnaires were compared between treatment and control groups using univariate analyses of covariance. Results: In total, n = 5148 EQ-5D responses and n = 894 MSQOL-54 physical, mental health and dimension scores were extracted. Baseline EQ-5D indices correlated with EDSS scores. After 2 years, pwRMS taking 3.5 ( p = .001) and 5.25 mg/kg ( p = .022) reported significantly improved EQ-5D index scores compared with placebo. Positive, yet non-significant, differences were detected in MSQOL-54 scores between cladribine and placebo. Conclusion: Analysis of the CLARITY dataset suggests that, over and above its established clinical efficacy, cladribine leads to improved QoL over 96 weeks. ClinicalTrials.gov identifier: NCT00213135.
Amount trumps timing in bilingual vocabulary acquisition: Effects of input in simultaneous and sequential school-age bilinguals
Authors: Thordardottir Elin 
Published: August 2017

Objectives: This study examined the extent to which the language performance of school-age bilingual children is impacted by the amount of language exposure they have received in each language versus the timing of this exposure in terms of the age of first exposure (AoE). Methods: Receptive and expressive vocabulary and word morphology measures were administered in both languages to school-age simultaneous and sequential learners of French (other language English), and to their monolingual counterparts. Data and analysis: The study included 64 children in first grade and 68 children in third grade in French schools in Montreal. Within each grade level, simultaneous bilinguals, sequential bilinguals, and monolinguals were equivalent in age, nonverbal cognition and socio-economic status (maternal education). Detailed information on previous language exposure was gathered by parent report. Conclusions: Simultaneous bilinguals performed somewhat better than sequential bilinguals; however both groups overall performed significantly more poorly than monolinguals. Differences in performance between simultaneous and sequential bilinguals were mediated by differences in amount, not timing, of exposure. Sequential learners in grade 1 required lower amounts of input to reach high French scores than did their simultaneous counterparts; sequential and simultaneous learners in grade 3 did not differ in this respect. This finding suggests that the recency of bilingual exposure is a significant determiner of the rate of second language learning. The amount of exposure to each language since birth predicted performance in each language of the bilingual children. Originality: Bilingual children with different AoEs were compared while also controlling for differences in amount of exposure. Significant implications: The results call into question the traditional separation between simultaneous and sequential bilinguals and shows that an early start of bilingualism does not in and of itself predict better performance or performance within the monolingual range. Better performance was more strongly related to amount than timing of exposure.
Reversal of Spinal Cord Ischemia Following Endovascular Thoracic Aortic Aneurysm Repair With Hyperbaric Oxygen and Therapeutic Hypothermia
Authors: Urquieta Emmanuel , Varon Joseph , Lin Peter H. 
Published: August 2017

Background: Neurological adverse events with spinal cord ischemia (SCI) remain one of the most feared complications in patients undergoing thoracic endovascular aortic repair (TEVAR). These patients can develop irreversible paraplegia with lifelong consequences with physical and psychological agony. Case Presentation: We herein present a patient who developed SCI with bilateral lower leg paraplegia on the third postoperative day following TEVAR. Spinal catheter was inserted for spinal fluid drainage. A hyperbaric oxygen therapy was initiated for 90 minutes for 2 days, which was followed by therapeutic hypothermia for 24 hours with a target temperature of 33°C. The patient exhibited significant neurological recovery following these treatments, and he ultimately regained full neurological function without spinal deficit. Discussion: This represents the first reported case of full neurological recovery of a patient who developed complete SCI following TEVAR procedure. The neurological recovery was due in part to immediate therapeutic hypothermia and hyperbaric oxygen therapy which reversed the spinal ischemia.
Dynamic chronic rectal obstruction causing a severe colonic dilatation in a cat
Authors: García-Pertierra Sofia , Gonzàlez-Gasch Esteban , Catalá Puyol Carmen , Closa Boixeda Jose María 
Published: August 2017

Case summary A 5-year-old male neutered domestic shorthair cat was presented to our referral centre with a 13 month history of chronic tenesmus due to malunion of the right caudal iliac body. Constipation and pelvic canal stenosis were initially addressed by the referring veterinarian with a right femoral head and neck excision and a right acetabulectomy without observable clinical improvement. At admission, abdominal radiographs revealed severe colonic distension and a narrowed pelvic canal caused by the right proximal femur. Rectal examination and colonography revealed a dynamic compression of the rectum, which worsened with femoral abduction and improved with femoral adduction. A right hindlimb amputation was performed to relieve the obstruction. The cat defaecated 2 days postoperatively and was discharged uneventfully. Neither faecal tenesmus nor dyschaezia were observed over the following 10 months. Relevance and novel information The dynamic nature of the rectal obstruction most likely prevented the development of an irreversible colonic dilatation leading to a megacolon. This is the first report describing a chronic dynamic rectal compression, which was successfully managed with a right hindlimb amputation without the need for subtotal colectomy.
Uterine torsion in a full-term pregnant cat
Authors: Kuroda Kohei , Osaki Tomohiro , Harada Kazuki , Yamashita Masamichi , Murahata Yusuke , Azuma Kazuo , Tsuka Takeshi , Ito Norihiko , Imagawa Tomohiro , Okamoto Yoshiharu 
Published: August 2017

Case summary A 5-year-old intact female Maine Coon cat presented with a 2 day history of lethargy, anorexia and anaemia. The cat had bred 60 days previously and jumped from a height 3 days earlier, which was followed by a worsening of its condition. Ultrasonography revealed that two fetuses had died and one remained alive. Urgent surgical intervention was deemed necessary, and the cat underwent a blood transfusion and laparotomy. The right uterine horn was dark red in appearance and had rotated 360° in the clockwise direction at its base. Subsequently, an ovariohysterectomy and caesarean section were performed, and the fetus in the left uterine horn initially survived. Although the cat appeared to recover from anaemia and physical injury, the kitten died on postoperative day 1. Relevance and novel information In cases involving only one twisted uterine horn, the fetuses located in the contralateral horn could potentially survive; however, many such fetuses do not survive, and only a few reports have described fetal survival in a pregnant cat with uterine torsion. In the present case, early surgical intervention and blood transfusion allowed us to save the cat. Our findings demonstrate the life-saving abilities of initial support treatment and early surgical intervention for both the pregnant cat and fetuses in cases of acute abdomen caused by uterine torsion.
Incidence of Second Anterior Cruciate Ligament Tears and Identification of Associated Risk Factors From 2001 to 2010 Using a Geographic Database
Authors: Schilaty Nathan D. , Nagelli Christopher , Bates Nathaniel A. , Sanders Thomas L. , Krych Aaron J. , Stuart Michael J. , Hewett Timothy E. 
Published: August 2017

Background: The reported rate of second anterior cruciate ligament (ACL) injuries (20%-30%), including graft failure and contralateral ACL tears, after ACL reconstruction (ACLR) or nonoperative therapy indicates that multiple factors may predispose patients to subsequent ACL injuries. Purpose: To determine the incidence of second ACL injuries in a population-based cohort over a 10-year observation period (2001-2010) and to identify factors that contribute to the risk of second injuries. Study Design: Descriptive epidemiological study. Methods: International Classification of Diseases, 9th Revision (ICD-9) codes relevant to the diagnosis of an ACL tear and the procedure code for ACLR were utilized to search the Rochester Epidemiology Project, a multidisciplinary county database, between the years of 2001 and 2010. The complete medical records for all cases were reviewed to confirm diagnosis and treatment details. A total of 914 unique patients with 1019 acute, isolated ACL tears were identified. These patients were stratified by primary and secondary tears, sex, age, activity level, side of injury, sex × side of injury, and graft type of reconstruction. Results: Second ACL tears were recorded in 141 (13.8%) of the 914 patients diagnosed with an ACL tear in Olmsted County, Minnesota, USA, from 2001 to 2010; 50.4% of these occurred in the contralateral knee. A noncontact mechanism was responsible for 76.4% of all ACL injuries. A second ACL injury was influenced by factors of sex × age group, treatment type × age group, and treatment type × activity level. Nonparametric analysis of graft disruption × graft type demonstrated that a higher prevalence of second ACL tears occurred with allografts compared with hamstring autografts ( P = .0054) and patellar tendon autografts ( P = .0001). Conclusion: The incidence of second ACL tears in this population-based cohort was 13.8%, and half occurred to the ACL of the contralateral knee. Statistically, second ACL injuries differed by sex, occurring in female patients younger than 25 years and male patients aged 26 to 45 years. Allografts continued to be associated with a greater risk of second ACL injuries compared with hamstring and patellar tendon autografts. Nonoperative treatment carried more risk of contralateral tears than ACLR.
Randomized Controlled Trial Testing the Efficacy of Platinum-Free Interval Prolongation in Advanced Ovarian Cancer: The MITO-8, MaNGO, BGOG-Ov1, AGO-Ovar2.16, ENGOT-Ov1, GCIG Study
Authors: Pignata Sandro , Scambia Giovanni , Bologna Alessandra , Signoriello Simona , Vergote Ignace B. , Wagner Uwe , Lorusso Domenica , Murgia Viviana , Sorio Roberto , Ferrandina Gabriella , Sacco Cosimo , Cormio Gennaro , Breda Enrico , Cinieri Saverio , Natale Donato , Mangili Giorgia , Pisano Carmela , Cecere Sabrina Chiara , Di Napoli Marilena , Salutari Vanda , Raspagliesi Francesco , Arenare Laura , Bergamini Alice , Bryce Jane , Daniele Gennaro , Piccirillo Maria Carmela , Gallo Ciro , Perrone Francesco 
Published: August 2017

Purpose Platinum-based chemotherapy (PBC) for patients with progressing ovarian cancer (OC) is more effective with a longer time interval from previous platinum treatment (platinum-free interval [PFI]). In 1999, it was hypothesized that prolonging PFI with single-agent non-PBC (NPBC) may offer a strategy to improve overall outcome. MITO-8 aimed to verify this hypothesis commonly used in clinical practice although it has not been prospectively tested. Methods MITO-8 is an open-label, prospective, randomized, superiority trial. Patients with OC who experienced disease progression 6 to 12 months after their last platinum treatment were randomly assigned 1:1 to the experimental sequence of NPBC followed by PBC at subsequent relapse or the standard reverse treatment sequence. Overall survival (OS) was the primary end point. Results Two hundred fifteen patients were enrolled (standard arm [n = 108]; experimental arm [n = 107]). The trial ended before planned because of slow enrollment. PFI was prolonged in the experimental arm (median, 7.8 v 0.01 months). There was no OS benefit in the experimental arm (median, 21.8 v 24.5 months; hazard ratio, 1.38; 95% CI, 0.99 to 1.94; P = .06). Progression-free survival after the sequence was significantly shorter in the experimental arm (median, 12.8 v 16.4 months; hazard ratio, 1.41; 95% CI, 1.04 to 1.92; P = .025). Global quality-of-life change after three cycles was worse in the experimental arm. Slight differences were observed in the incidence of adverse effects. Conclusion MITO-8 supports the recommendation that PBC not be delayed in favor of an NPBC in patients with partially platinum-sensitive OC. PBC should be used as a control arm in future trials of new drugs in this setting.
Comparison of Physical Adsorption Strength of Protective Agents via Ligand Exchange of Silver Nanoparticles Prepared by Vacuum Evaporation on Running Oil Substrate
Authors: Ienaga Takashi , Okada Soichiro , Nakahara Yoshio , Watanabe Mitsuru , Tamai Toshiyuki , Yajima Setsuko , Kimura Keiichi 
Published: August 2017

Abstract
We compared adsorption strength of protective agents via ligand exchange of silver nanoparticles synthesized by the improved vacuum evaporation on running oil substrate (VEROS) method. This comparison concerns physical adsorption of protective agents on the surface of silver nanoparticles instead of chemisorption. Clean surfaces of silver nanoparticles synthesized by the improved VEROS method were suitable for this investigation. All the experiments in this study were designed so that as far as possible protective agents did not ionize. Thus, oleic acid capped silver nanoparticles were synthesized by the improved VEROS method. Next, octanoic acid, n-octylamine and oleic acid were used as additive protective agents in ligand exchanges. The ligand exchange is also closely related to physical adsorption strength of protective agents on the surface of metal nanoparticles. Oleic acid on the surface of silver nanoparticles was exchanged by octanoic acid and vice versa under the same experimental conditions. On the other hand, oleic acid on the silver surface was not exchanged by n-octylamine. These results were remarkably different from those reported in general chemical synthetic methods but they were well consistent with our previous study on performance of protective agents in the synthesis of silver nanoparticles with the improved VEROS method.
Open or closed exposure for palatally impacted maxillary canines? A review
Authors: Alkadhimi Aslam Fadel , Ganesan Kandasamy , Al-Awadhi Ebrahim A 
Published: August 2017

Palatally impacted canines (PICs) can be surgically exposed using one of the two exposure methods: open or closed. There is generally lack of consensus with regards to the preferred exposure method, hence the choice of operative technique remains open to discussion. The two techniques are compared and the choice of surgical technique is assessed in terms of patient factors, orthodontic/surgical and radiographic factors. Taking all possible determinant factors into account, a flowchart for the selection of the surgical exposure technique is presented. CPD/Clinical Relevance: As there are no clinical guidelines currently in the literature for the selection of surgical exposure method of PICs, carrying out this review article might help orthodontists and oral surgeons (especially juniors) in the selection process by following the proposed flowchart presented in this article, based on the available evidence in the literature.
Radiostereometric migration measurement of an uncemented Cerafit® femoral stem: 26 patients followed for 10 years
Authors: Sesselmann Stefan , Hong Yotung , Schlemmer Frank , Hussnaetter Isabell , Mueller Lutz A. , Forst Raimund , Tschunko Franz 
Published: August 2017

AbstractRadiostereometric analysis (RSA) is the gold standard for evaluating micromotions of orthopaedic implants. The method is applied for identifying novel design weaknesses in endoprostheses. Current research frequently assesses relatively short time periods. Short-term RSA studies have been widely used for predicting the long-term stability of many hip prosthetic designs, but only a few studies have focused on uncemented hip implants, especially for extended periods. The purpose of this study was to analyse the migration pattern of the Cerafit®femoral stem within 10 years and to verify the predictive value of short-term RSA after 2 years for this uncemented femoral hip stem. Twenty-six patients were followed for 10 years. Ten years after implantation, a mean subsidence of 0.22 mm±0.56 mm, a mean internal rotation of 0.59°±1.67° and a mean maximum total point motion (MTPM) of 1.28 mm±0.54 mm were detected. The main migration took place in the first 6 weeks after surgery (subsidence of 0.36 mm±0.73 mm; internal rotation of 0.62°±1.49°, MTPM of 1.05 mm±0.68 mm). All the migration values measured were small. No late-onset migration was observed. This study suggests that the Cerafit®implants are stable after 10 years. Thus, RSA could be the best tool to assess long-term implant behaviour.
Teachers’ perceptions on the changing role of language in the curriculum
Authors: Skinnari Kristiina , Nikula Tarja 
Published: August 2017

AbstractThis article is concerned with the role of language(s) in education from the viewpoint of secondary school subject teachers in Finland at the time of transition to a new curriculum. The curriculum highlights the role of language throughout education and makes reference to changes in society that foreground multilingualism. Seven mainstream and CLIL content teachers of different subjects were interviewed and employing qualitative content analysis, the data were scrutinised under four language-related themes: multilingualism, multiliteracy, subject-specific language, and the role of language in knowledge construction. The results indicate teachers as reasonably well aware of subject-specific language of their field and of the value of multiliteracy practices. Multilingualism as the diversity of students’ languages and its impact on pedagogical practices received less attention. Overall, the teachers’ orientation to the language ideological statements in the new curriculum were widely agreed upon even if the ideas still remained somewhat abstract in the transition phase before actual implementation to the praxis.
Geochemistry of sandstones and shales from the Ecca Group, Karoo Supergroup, in the Eastern Cape Province of South Africa: Implications for provenance, weathering and tectonic setting
Authors: Baiyegunhi Christopher , Liu Kuiwu , Gwavava Oswald 
Published: August 2017

AbstractGeochemical compositions of twenty-four sandstone and shale samples from the Ecca Group were analysed to decipher their provenance, paleoweathering conditions and tectonic setting. The shales have high Fe
Catalytic oxidation of lignin to dicarboxylic acid over the CuFeS2 nanoparticle catalyst
Authors: Bi Zhihao , Li Zhihao , Yan Lifeng 
Published: August 2017

AbstractCuFeS2nanoparticles have been synthesized and used as catalyst for the degradation of lignin. Under mild condition of reaction at 60°C and 5 h in the presence of 2 ml hydrogen peroxide, lignin can be degraded completely and converted to dicarboxylic acids, such as oxalic acid (OA), fumaric acid, maleic acid, and succinic acid (SA), carbon oxides, and aromatic compounds. The major product is OA (up to 30% selectivity) and SA. On the basis of the chemicals detected, we proposed a logical mechanism similar to Fenton reaction. The results reveal that HO˙ and HOO−, formed from the cleavage of hydrogen peroxide over the catalyst, play an essential role in the oxidation of lignin to destroy its aromatic structure and generate carboxylic or DCA. This is a potential method to convert native lignin as a renewable feedstock to produce valuable chemicals.