bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Physico-chemical and Biological Properties of Fermented Nipa (Nypa fruticans) Sap Under Closed and Open Vessel Fermentation System for Bioethanol Production
Authors: Manzano Loreli Faye T. , Halabaso Eric R. , Aglipay Laurenz R. , Gamboa Francis A. , Agrupis Shirley C. 
Published: October 2024

Background
The potential of Nipa (Nypa fruticans) sap in the Cagayan Region, Philippines, for bioethanol production remains largely underexplored despite its vast expanse.

Methods
This study investigates the key physico-chemical properties of Nipa sap from Aparri, Cagayan, with a focus on fermentation dynamics and storage conditions to optimize ethanol production. Two fermentation treatments closed and open vessel conditions, were compared to determine the optimal conditions for maximum ethanol yield. Over a 7-day fermentation period, the acetic acid production, yeast activity, sugar content, and ethanol concentration of closed vessel fermented sap (CVFS) and open vessel fermented sap (OVFS) were monitored.

Results
CVFS demonstrated a higher ethanol yield (7.56%v/v at peak day), characterized by minimized acetic acid accumulation and stable yeast activity. In contrast, OVFS exhibited significant fluctuations in acetic acid and ethanol levels, indicating a lower fermentation efficiency.

Conclusion
The presence of methanol and high acetic acid content in open-vessel fermentation systems highlights the importance of fermentation conditions to prevent impurities. This study provides valuable insights into optimizing ethanol production from fermenting Nipa sap by employing closed vessel fermentation, which is crucial for sustainable bioethanol production in the Cagayan region.
Factors Related to mHealth App Use Among Japanese Workers: Cross-Sectional Survey
Authors: Ozaki Itsuko , Nishijima Mariko , Shibata Eiji , Zako Yuri , Chiang Chifa 
Published: October 2024

Background
Health care providers can make health guidance more effective by using mobile health technologies such as health apps. Although health care providers need to know who uses health apps, existing studies have yielded inconsistent results.

Objective
The aim of the study was (1) to clarify the prevalence and patterns of health app use to improve health behaviors for preventing lifestyle-related diseases among Japanese workers and (2) to identify the associations among demographic characteristics, health behavior, and internet use and health app use by gender.

Methods
Data were collected from a cross-sectional internet survey in 2023. In total, 2200 participants were included, with an even distribution of men and women in each age group aged 20 to 60 years. The participants were workers with smartphones and reported their gender, age, residence area, marital status, education, employment status, occupation, work pattern, diseases under treatment, health checkups, health guidance, health behaviors, internet use duration, and number of devices used. We asked about current and previous health app use for 1 month. A multivariate logistic regression analysis was conducted by gender.

Results
Of the participants, 472 (21.5%) and 189 (8.6%) were current and previous health app users, respectively. Most current and previous health app users used features that record and track their physical activity and other health behaviors. Health app users—both men and women—were more likely to have health checkups (odds ratio [OR] 1.53, 95% CI 1.12-2.11 and OR 1.51, 95% CI 1.10-2.07, respectively), receive health guidance (OR 2.01, 95% CI 1.47-2.74 and OR 1.86, 95% CI 1.32-2.62, respectively), engage in regular physical activity (OR 2.57, 95% CI 1.91-3.47 and OR 1.94, 95% CI 1.41-2.67, respectively), use the internet for 120-179 minutes per day (OR 1.76, 95% CI 1.13-2.75 and OR 1.70, 95% CI 1.12-2.57, respectively), and were less likely to be older (50-59 years: OR 0.54, 95% CI 0.33-0.88 and OR 0.40, 95% CI 0.25-0.6, respectively, and 60-69 years: OR 0.37, 95% CI 0.22-0.62 and OR 0.47, 95% CI 0.28-0.77, respectively). According to gender, male health app users were more likely to be married (OR 1.69, 95% CI 1.23-2.33) and less likely to work in the security, agriculture, forestry, fishing, manufacturing, or transportation industries (OR 0.62, 95% CI 0.41-0.95). Female health app users were more likely to have a university education or higher (OR 1.55, 95% CI 1.061-2.26), maintain an appropriate body weight (OR 1.52, 95% CI 1.10-2.11), and use 3 or more devices (OR 2.13, 95% CI 1.41-3.23).

Conclusions
Physical activity and health guidance are strong predictors of app use. Health care providers should assess the target populations’ preferences for app use based on their characteristics, support their app use, and enhance the effectiveness of health guidance.
Aktivitas Antibakteri Daun Polyscias scutellaria, Carica papaya, dan Kombinasinya terhadap Propionibacterium acnes
Authors: Mardiyaningsih Ana , Ismiyati Nur , Hariyanti Laras , Irianto Iramie Duma Kencana , Zaenirohmah Rizqi Rochim 
Published: October 2024

Propionibacterium acnes merupakan salah satu jenis bakteri penyebab jerawat. Bakteri initumbuh pada kondisi anaerob dan lipofilik di daerah pori-pori kulit yang tertutup oleh sel kulit mati dan asam lemak. Kondisi tersebut dipicu oleh ketidakseimbangan hormon yang menyebabkan peningkatan produksi sebum yang disertai hiperkeratinisasi. Klindamisin merupakan antibiotik yang dapat digunakan untuk mengatasi infeksi bakteri P.acnes, namun penggunaannya dalam jangka waktu lama dapat memicu resistensi dan membunuh mikroba baik pada kulit. Alternatif pengobatan jerawat yang aman dan efektif dapat dilakukan melalui pengembangan ekstrak dari P. scutellaria maupun C.papaya, yang berdasar penelitian sebelumnya menunjukkan potensi antimikroba. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak heksan daun P.scutellaria, C.papaya serta kombinasinya terhadap P.acnes. Bahan yang diteliti adalah daun P.scutellaria dan C.papaya. Preparasi ekstrak dilakukan dengan metode maserasi menggunakan pelarut heksan. Evaluasi ekstrak meliputi organoleptik, rendemen, susut pengeringan dan analisis kualitatif dengan KLT. Uji aktivitas antibakteri terhadap P.acnes ATCC6919 menggunakan metode difusi cakram dengan kontrol negatif DMSO, dan kontrol positif klindamisin. Ekstrak yang diperoleh memiliki karakteristik spesifik sesuai dengan bahan baku. Rendemen kedua ekstrak yang diperoleh ¼ dari bobot serbuk awal. Susut pengeringan kedua ekstrak sangat kecil (<1%). Baik P.scutellaria maupun C.papaya mengandung banyak senyawa golongan terpenoid. Aktivitas antibakteri ekstrak heksan daun C.papaya lebih kuat dibandingkan P.scutellaria. Kombinasi kedua ekstrak dengan perbandingan 1:1 menunjukkan aktivitas antibakteri yang tertinggi dibandingkan dengan perlakuan yang lain. Kombinasi kedua ekstrak tergolong dalam antibakteri kuat
Analisis Kebutuhan Sistem Informasi Manajemen Inventory Instalasi Farmasi Pemerintah Provinsi Kalimantan Tengah
Authors: Filirida Meidina , Lazuardi Lutfan , Satibi Satibi 
Published: October 2024

Manajemen inventaris Instalasi Farmasi Pemerintah (IFP) Provinsi Kalimantan Tengah masih dilakukan secara semi konvensional yang menyebabkan selisih stok obat; selisih stok kartu; pelaporan lama; data tidak real time ; kehilangan dokumen . Hal ini membuat pengelolaan informasi dalam proses tersebut menjadi sangat vital sehingga perlu dilakukan analisis kebutuhan untuk pengembangan Sistem Informasi Manajemen (SIM) Inventory di IFP. Penelitian ini bertujuan menganalisis kebutuhan pengguna untuk pengembangan SIM Inventory IFP. Penelitian ini merupakan studi kualitatif deskriptif kasus yaitu analisis kebutuhan SIM Inventory menggunakan metode wawancara mendalam,Focus Group Discussion , dan telaah dokumen dengan pendekatan U ser-Centered Design . Subyek penelitian terdiri dari Kepala Dinas Kesehatan; Sekretaris Dinas Kesahatan; Kepala Bidang Sumber Daya Kesehatan; Kepala Seksi Farmasi, Alat Kesehatan, dan Perbekalan Kesehatan Rumah Tangga; Apoteker Penanggung Jawab IFP Provinsi; 3 orang apoteker IFP Provinsi; 1 orang Tenaga Teknis Kefarmasian IFP Provinsi; 6 orang apoteker IFP kabupaten/kota di Kalimantan Tengah; 1 orang anggota tim Teknologi Informasi Kementerian Kesehatan Republik Indonesia. Hasil penelitian menunjukkan kebutuhan manajemen data inventoryIFP terdiri dari data penerimaan sediaan farmasi, data distribusi sediaan farmasi, data stok opname sediaan farmasi, data pemusnahan sediaan farmasi, dan pengembalian sediaan farmasi. Kebutuhan data menyusut ke dalam kebutuhan penerimaan data, distribusi, dan pelaporan yang terdiri dari 6 jenis laporan. Kesimpulan penelitian ini adalah analisis kebutuhan pengguna dalam pengelolaan inventaris IFP menghasilkan kebutuhan data yang mendukung proses penerimaan, distribusi, dan pelaporan.
Pola Pemberian Nutrisi Parenteral Pada Neonatus di RSUPN dr. Cipto Mangunkusumo. Indonesia
Authors: Mahmuda Hartati , Rahmawati Fita , Mutiara Rina 
Published: October 2024

Neonatus merupakan pengguna terapi nutrisi parenteral paling banyak karena sebagian besar bayi prematur dan bayi lahir dengan berat sangat rendah akan membutuhkan terapi dukungan nutrisi sesegera mungkin setelah lahir. Pemberian nutrisi parenteral pada neonatus dapat mempengaruhi pertumbuhan pasca-kelahiran, meningkatkan perkembangan saraf, dan mengurangi risiko kematian. Penelitian ini bertujuan untuk mengetahui pola pemberian nutrisi parenteral yang diberikan pada neonatus diawal kelahiran. Penelitian ini menggunakan desain observational cross sectional. Penelusuran riwayat pemberian nutrisi parenteral pada neonatus dilakukan secara retrospektif melalui rekam medik dan sistem informasi manajemen rumah sakit. Sejumlah 118 neonatus memenuhi kriteria inklusi penelitian dengan kriteria berat badan ≤ 2.500 g, mendapatkan nutrisi parenteral di bangsal perinatologi, RSUPN dr. Cipto Mangunkusumo Jakarta. Informasi jenis nutrisi parenteral yang diberikan kepada neonatus pada hari pertama kelahiran dianalisis secara deskriptif. Hasil penelitian menunjukkan jenis nutrisi parenteral yang diberikan meliputi makronutrisi berupa glukosa, protein, dan lipid serta mikronutrisi multivitamin, kalsium, dan fosfat. Sejumlah 35 neonatus mendapatkan nutrisi protein-glukosa dengan atau tanpa mikronutrisi, 23 neonatus dengan nutrisi protein-glukosa-lipid dengan atau tanpa mikronutrisi sejumlah 60 neuonatus dengan nutrisi glukosa dengan atau tanpa mikronutrisi. Nutrisi parenteral yang diberikan beragam sesuai kebutuhan masing-masing neonatus agar tidak terjadi malnutrisi.
Frekuensi Alergi Makanan Berdasarkan Survei pada Orang Dewasa di Wilayah Yogyakarta dan Jawa
Authors: Azizah Zulfi , Falihah Atika Hanum , Santoso Bayu Bakti Angga , Sari Ika Puspita , Sahid Muhammad Novrizal Abdi 
Published: October 2024

Alergi makanan merupakan suatu kondisi hipersensitivitas akibat respon berlebih dari sistem imun terhadap paparan makanan tertentu yang dapat menyebabkan berbagai gejala klinis. Jenis makanan penyebab alergi serta frekuensi kejadian alergi makanan sangat beragam. Selain itu, insidensi alergi makanan dapat meningkat seiring waktu. Informasi mengengenai frekuensi kejadian alergi, jenis alergen, dan gejala yang ditimbulkan pada kelompok usia dewasa di Indonesia masih terbatas. Penelitian ini bertujuan untuk mengetahui frekuensi alergi makanan, komponen makanana pemicu, serta gejala yang umum ditimbulkan pada kelompok dewasa usia 20-40 tahun di wilayah Yogyakarta dan Jawa. Penelitian dilakukan menggunakan survey online yang dilakukan selama bulan Februari-Mei 2023. Dari penelitian tersebut, didapatkan 97 responden dengan 32 orang (33%) diantarannya mengalami alergi makanan. Kejadian alergi makanan pada wanita sebesar 68.7% sedangkan pada laki-laki sebesar 31.3%. Jenis makanan yang banyak menyebabakan alergi yaitu udang (29.2%), kepiting (16.7%), kerang (14.6%) dan ikan (12.5%). Sedangkan gejala alergi makanan yang paling sering terjadi yaitu reaksi pada kulit dan saluran pencernaan. Hasil studi menunjukkan insidensi kejadian alergi makanan sebesar 33% dengan kejadian alergi makanan pada perempuan lebih besar dibandingkan pada laki-laki. Jenis makanan yang paling umum menyebabkan alergi makanan adalah udang dan gejala yang paling umum muncul berkaitan dengan reaksi pada kulit dan saluran pencernaan.
Perbandingan Efektivitas dan Keamanan Terapi Antidiabetika pada Pasien Diabetes dengan Penyakit Ginjal Kronik di RSUD Dr. Moewardi Surakarta
Authors: Safitri Nurul , Andayani Tri Murti , Yasin Nanang Munif 
Published: October 2024

Kontrol glikemik pada pasien DMT2 memiliki hubungan terhadap kadar serum kreatinin sehingga pemberian terapi yang efektif dan aman menjadi fokus utama dalam terapi. Penelitian ini bertujuan untuk mengetahui efektivitas dan efek samping terapi diabetes melitus yaitu insulin dibanding glikuidon pada pasien diabetes melitus (DM) dengan PGK pada pasien rawat jalan di RSUD Dr. Moewardi Surakarta. Penelitian ini merupakan penelitian observasional dengan rancangan cohort retrospektif. Pengambilan data dilakukan dengan menggunakan metode consecutive sampling dengan cara meninjau catatan medis pasien rawat jalan penderita diabetes melitus tipe 2 (DMT2) dengan komplikasi PGK yang menerima terapi antidiabetik insulin maupun antidiabetik glikuidon di RSUD. Dr. Moewardi Surakarta periode Januari – April 2022. Sebanyak 120 pasien diabetes dengan PGK yang menjalani rawat jalan, 64 pasien memenuhi kriteria inklusi. Hasil penelitian menunjukkan bahwa usia pasien didominasi oleh usia 18-59 tahun (82,81%), pasien pada penelitian ini lebih banyak ditemukan pada jenis kelamin laki-laki yaitu 23 pasien kelompok glikuidon (71,87%) dan 15 pasien kelompok insulin (46,87%). Terjadi penurunan kadar GDP dan GD2JPP pada kedua kelompok setelah 6 bulan periode terapi. Tidak ditemukan adanya kejadian hipoglikemia pada kedua kelompok. Kelompok glikuidon menunjukkan penurunan fungsi ginjal yang tidak signifikan dibandingkan insulin. Kelompok insulin memiliki rata-rata nilai eGFR sebelum terapi sebesar 49,65 mL/mnt/1,73 m 2 dan setelah terapi selama 6 bulan sebesar 60,74 mL/mnt/1,73 m 2. Terdapat perbaikan nilai ureum pada kedua kelompok walaupun tidak terdapat perbedaan signifikan berdasarkan statistik.
Evaluación del estado de volumen en el paciente con lesión renal aguda: ¿a qué se refiere el nefrólogo con mantener una volemia adecuada?
Authors: Marín Restrepo Leonardo , Cedeño Arévalo Susy Vanessa , Miño Bernal Jorge Fernando , Álvarez-Echeverry Ingrid 
Published: October 2024

Contexto: la lesión renal aguda (LRA) es una condición frecuentemente encontrada por el nefrólogo, tanto en unidades de cuidado crítico como en salas de hospitalización.
Objetivo: profundizar en los principales determinantes fisiopatológicos del estado de volumen y la aplicación clínica de estos en la cabecera del paciente crítico.
Metodología: este artículo explica la fisiología de la administración de los LEV, discute críticamente los patrones de prescripción actuales y examina los dispositivos y las pruebas más frecuentemente utilizadas para la monitorización hemodinámica y predecir la respuesta a la administración de volumen.
Resultados: la primera causa para descartar siempre es la hipovolemia y el manejo inicial de esta se realiza usualmente a través de la administración temprana de líquidos endovenosos (LEV), incluso antes de la evaluación por el nefrólogo. Es importante que este especialista comprenda que la administración adicional de líquidos no es inocua y puede llevar a la sobrecarga de volumen. Por lo tanto, la administración de LEV solo debería realizarse posterior a una maniobra de respuesta a volumen positiva.
Conclusiones: se propone un algoritmo para guiar la administración de volumen en pacientes con LRA.
Análise da representação contábil em empresas de capital aberto nas operações de risco sacado com base no ofício circular CVM nº 01/2016
Authors: Faria Natália Lage de , Colares Ana Carolina Vasconcelos 
Published: October 2024

A operação de risco sacado ganhou destaque dado a divulgação de inconsistências na representação desta transação nas demonstrações da Americanas S.A. Sendo assim, tendo como base as premissas do ofício CVM n° 01/2016, esse artigo teve como objetivo analisar a representação do risco sacado em 20 empresas de capital aberto nos anos de 2021 e 2022. Assim, foi possível observar que 20% das empresas não divulgaram a operação no ano de 2021,enquanto em 2022 a divulgação subiu para 100%. Observou-se também um aumento médio de 19% no atendimento ao ofício de 2021 para 2022. Por fim, verificou-se que a operação foi apresentada em contas e nomenclaturas distintas pelas companhias. Conclui-se, que apesar da melhoria nos percentuais a operação não foi apresentada de forma clara e em conformidade com o ofício nº 01/2016, visto que nenhuma empresa atendeu em 100% aos itens analisados e a representação não ocorre de forma homogênea.
Correlations Between Viro-Immunologic Status of the Newly Diagnosed Patient with HIV Infection and Liver Damage
Authors: Iancu Ana-Maria , Rugina Sorin 
Published: October 2024

Abstract
Liver damage can be a direct consequence of human immunodeficiency virus infection or indirect mechanisms triggered by human immunodeficiency virus. Hepatic fibrosis may be present in patients newly diagnosed with HIV infection or in those with viro-immunologic failure after initiation of antiretroviral therapy. In the present study we evaluated biologically and viro-immunologically the 351 patients newly diagnosed with HIV infection in the Regional Center Constanta between 01.01.2015 and 31.06.2024, subsequently re- evaluated one year after diagnosis and institution of specific medication. Liver fibrosis stage was assessed using APRI, FIB4 and FORNS scores. The cohort comprised 351 patients, 313 with HIV monoinfection. The mean age at diagnosis was 36.09 years, predominantly male (237 patients). The median CD4+ cell count was 269.5 cells/mm3, and the median HIV-RNA was 164 x103 copies/mL. Most cases were CDC staged A2 (91 cases) and C3 (77 cases). Patients with HIV monoinfection showed a significant association between CD4+ cell level and ALT (p=0.026) and AST (p<0.001), respectively. We observed statistically significant correlation between AST and viral load values (p=0.003 in monoinfection and 0.042 in coinfection). APRI, FIB4 and FORNS scores averaged higher in the coinfected group compared to the HIV monoinfected group. Statistically significant associations were found between APRI, FIB4, FORNS scores and CD4+ cell counts and HIV viral load values, respectively.
Gemeinschaftsdiagnose Herbst 2024: Deutsche Wirtschaft im Umbruch
Authors: Dany-Knedlik Geraldine , Holtemöller Oliver , Kooths Stefan , Schmidt Torsten , Wollmershäuser Timo 
Published: October 2024

Abstract
The German economy has stagnated for over two years, with a slow recovery anticipated in the coming quarters. However, growth is unlikely to reach pre-COVID-19 levels anytime soon. Decarbonisation, digitisation, demographic changes, and heightened competition from China are dampening growth prospects. GDP is projected to decline by 0.1 % in 2024, with increases of 0.8 % and 1.3 % in the subsequent years. Rising private consumption and improving foreign trade are expected to contribute positively to the economic upturn in Germany. Economic policy should prioritise reducing productivity barriers, facilitating structural changes, and lowering political uncertainty to support recovery.
Prerequisites for Increasing Contradictions between Iran and Afghanistan over the Use of Transboundary Water Resources of the Helmand River
Authors: Sinelnikov D. A. 
Published: October 2024

Since the second half of the 20th century, issues related to the provision of water resources have become of paramount importance for the countries of the Greater Middle East. First of all, this is due to the fact that against the backdrop of a continuous increase in demand for a vital resource, there is almost no publicly available alternative.The water crisis in Iran has become a national problem over the past 10 years. Against this background, the country’s leadership is forced to defend its rights to the joint use of transboundary water resources in a more stringent manner. At the same time, while with some neighboring states problems of joint water use began to appear relatively recently, with Afghanistan water disputes over the re-sources of the Helmand River already have a history of more than a century and a half. During this time, the countries have managed to accumulate many contradictions, which still do not allow them to find a way out of the current situation that suits each of the parties.The author concludes that the current situation with the distribution of water resources of the transboundary Helmand River does not suit either side. While Iran, located in the lower reaches of the river, is in a clearly losing position, Afghanistan can use its advantageous geographical position to advance its own interests. The situation around the dispute between Iran and Afghanistan over water resources is extremely unstable and has the potential for a sharp aggravation. The problem, fueled by historical contradictions and other factors discussed in the article, is acquiring critical status for both countries, and its further ignoring might lead to an aggravation of the conflict.
Hepcidin, GDF-15 and their Impact on Iron Metabolism in CKD
Authors: Das Priyanka , Baba KSS Sai , Sreedevi N.N. , Raju Sree Bhushan , Khan Siraj Ahmed , Bhaskar M. Vijaya , Mohammed Noorjahan 
Published: October 2024

Background
Anemia is an important complication in chronic kidney disease (CKD). We studied the diagnostic accuracy of hepcidin and growth differentiation factor-15 (GDF-15) as early markers of iron deficiency anemia (IDA) in non-dialysis (ND-CKD) patients.

Materials and Methods
This was a cross-sectional, case-control study comprising 100 cases of CKD (newly diagnosed and non-dialyzed) and 40 healthy controls. Serum levels of hepcidin and GDF-15 were estimated using ELISA-based assays. Receiver operator characteristics were used to evaluate the diagnostic validity of hepcidin and GDF-15 for absolute and functional iron deficiency anemia.

Results
About 33% of the cases were females with a mean age of 47.64 (± 13.68) years. The predictive value of hepcidin for diagnosing functional IDA in CKD was found to be 69.1% (95% CI: 52.5% to 82.7%), and that of GDF-15 was found to be 68.8% (95% CI: 52.6% to 82.1%). Hepcidin significantly correlated with hemoglobin (r = 0.278, p = 0.005) and serum iron (r = 0.222; p = 0.025). GDF-15 positively correlated with ferritin (r = 0.346, p < 0.0001) and hsCRP (r = 0.223, p = 0.0088) and negatively correlated with eGFR (r = -0.462, p < 000001), Hb (r = -0.481, p < 0.00001) and TIBC (r = -0.353, p < 0.0001).

Conclusion
Hepcidin and GDF-15 could predict functional IDA in our patients but not absolute IDA.