bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of body composition by dual x‐ray absorptiometry in persons with haemophilia
Authors: Ransmann Pia , Brühl Marius , Hmida Jamil , Goldmann Georg , Oldenburg Johannes , Strauss Anna Christina , Hagedorn Thorsten , Schildberg Frank Alexander , Hilberg Thomas , Strauss Andreas Christian 
Published: September 2024

AbstractBackgroundThere is limited research on body composition in persons with haemophilia (PwH). The literature describes an increased body fat distribution and decreased lean mass in PwH compared to healthy controls using bioimpedance analysis. Using dual x‐ray absorptiometry (DXA), which is known to be the most accurate method, this investigation aims to postulate reference data for body composition parameters within haemophilia severity phenotypes and age groups.MethodsPersons underwent whole body DXA screening using Horizon. Body fat percentage, estimated visceral adipose tissue (VAT), appendicular fat and lean mass, and lean and fat mass in relation to body height were assessed. Haemophilia severity and five age groups were distinguished.ResultsTwo hundred and one persons with mild (n = 44), moderate (n = 41), or severe (n = 116) haemophilia A/B (median age 40 [28–55; 1.IQ–3.IQ] years) were analysed. The median body fat percentage was 28.7% [25.5%–33.9%] and median estimated VAT was 657 g [403–954 g] with no significant difference between severity phenotypes (p = .474; p = .781). Persons with severe haemophilia had less lean mass compared to moderate and mild haemophilia (p = .013; p = .034). Total and appendicular fat is increased in older PwH (aged ≥40 years) compared to younger PwH (aged ≤29 years; p < .05). Lean mass did not differ between age groups.ConclusionThis study provides valuable reference data for body composition parameters in PwH. Persons with severe haemophilia show significantly less lean mass compared to persons with moderate or mild haemophilia. Body fat percentage and VAT did not differ between severity phenotypes, but increased with age.
Regulation of dermal circadian pathways by a novel topical formulation
Authors: DeHaven Charlene , Wheeler Stephanie , Langerveld Anna , Johns C. Bryan 
Published: September 2024

AbstractSkin health is impacted by a wide range of intrinsic and extrinsic factors (J Dermatol Sci, 2017, 85, 152), including those that impact circadian rhythm, such as sleep disruption (Textbook of Aging Skin, 2016), UV (Biomed Aging Pathol, 2013, 3, 161) and blue light (Int J Cosmet Sci, 2019, 41, 558). Disruption of the skin's endogenous circadian balance, even by a consistently late bedtime, has deleterious effects on multiple measurements of skin health, including hydration, skin barrier protection, microbiome counts and skin regeneration, among others (Clin Cosmet Investig Dermatol, 2022, 15, 1051). Skin repair processes occur at night and help to maintain important aspects of skin health (FEBS Lett, 2021, 595, 2413). Interest is increasing in the development of topical products that help restore proper circadian function. This study demonstrates that a proprietary topical formulation regulates new and established gene and protein biomarkers of circadian entrainment and circadian rhythm, demonstrating the product's potential to maintain appropriate dermal diurnal balance.
Macrophage polarization in human periapical lesions in relation to histopathological diagnosis, clinical features and lesion volume: An ex vivo study
Authors: Visarnta Supanant , Ratisoontorn Chootima , Panichuttra Anchana , Sinpitaksakul Phonkit , Chantarangsu Soranun , Dhanuthai Kittipong 
Published: September 2024

AbstractAimTo evaluate M1 and M2 macrophage polarization in radicular cysts and periapical granulomas through an immunohistochemical analysis and the correlation between macrophage polarization and histopathological diagnosis, clinical characteristics and lesion volume using cone‐beam computed tomography.MethodologyPeriapical biopsies diagnosed as radicular cysts (n = 52) and periapical granulomas (n = 51) were analysed by immunohistochemical method. Teeth with periapical lesion with no history of root canal treatment (primary lesion) and lesions persistent to root canal treatment (persistent lesions) were included. Pathological diagnosis, patients' age, gender and clinical characteristics were obtained from treatment records. A cone‐beam computed tomographic periapical volume index (CBCTPAVI) score was assigned to each periapical lesion based on the volume of the lesion. Immuno‐expressions of CD68 and CD163 were quantified. The CD68/CD163 ratio was adopted to represent M1 or M2 macrophage polarization. Mann–Whitney U test was used to determine the different CD68/CD163 ratio between groups of radicular cyst and periapical granuloma. Spearman's correlation test was performed to assess the correlation between the CD68/CD163 ratio and lesion volume and CBCTPAVI score.ResultsRadicular cysts and periapical granulomas had CD68/CD163 median of 2.05 (IQR = 1.33) and 1.26 (IQR = 0.81), respectively. A significantly higher CD68/CD163 ratio was observed in radicular cysts (p < .001). In contrast, periapical granulomas had significantly lower median of CD68/CD163 ratio. Larger lesions had a higher median of CD68/CD163 ratio, while smaller lesions had lower median of CD68/CD163 ratio (p = .007, rs = .262). CD68/CD163 ratio was significantly correlated with the CBCTPAVI score in the overall periapical lesions (p = .002, rs = .306). The higher CD68/CD163 ratio in larger lesions indicated a higher degree of M1 polarization compared to smaller lesions. Regarding the pathological diagnosis, there was a significant positive correlation between CBCTPAVI score and CD68/CD163 ratio in periapical granulomas (p < .001, rs = .453), whereas the negative correlation was observed for radicular cysts (p < .001, rs = −.471).ConclusionsPeriapical granulomas are characterized by a M2‐dominant macrophage polarization, while radicular cysts have significantly higher M1 macrophages. The higher degree of M1 macrophage polarization was significantly correlated with larger volume and higher CBCTPAVI scores of overall periapical lesion and periapical granuloma.
Packaging, perception, and acceptability: a comprehensive exploration of extrinsic attributes and consumer behaviours in novel food product systems
Authors: Mehta Annu , Serventi Luca , Kumar Lokesh , Morton James D. , Torrico Damir D. 
Published: September 2024

SummaryIn today's global markets, the constant arrival of new products represents a challenge for the food industry to offer distinct choices to consumers, primarily due to the parallel sensory attributes and pricing structures of the available food options. Innovators must employ methodologies beyond traditional sensory analysis to ensure the product's success. Researchers must, therefore, explore the entire product experience to understand its influence on consumer behaviours. Food choices are multifaceted, influenced by various factors, including individual physiological and psychological characteristics and intrinsic and extrinsic product attributes. As a result, consumers' decisions are shaped by the multisensory information derived from products they encounter in supermarkets. This review aims to comprehensively examine the factors influencing consumer food choices, from initial product encounters to consumption. The review explores the impact of repetitive tasting on the consumer's attitudes and intentions towards novel products. Additionally, the review investigates which extrinsic attributes capture consumer attention in supermarket settings. It also delves into the effects of extrinsic product attributes on both explicit and implicit emotions and expectations raised about the sensory properties of the product and, ultimately, their purchasing behaviours.
The future of hybrid foods: will consumers embrace dairy‐plant blends?
Authors: Curutchet Ana , Arcia Patricia , Rodríguez Arzuaga Mariana 
Published: September 2024

SummaryThis study investigated the perception of Uruguayan consumers towards hybrid dairy‐like products, including beverages and yogurts made with a mix of milk and plant proteins from canola, hemp, or soy. The study was conducted online with 261 participants, using a 2 × 4 experimental design to analyse consumer responses to product type and protein source. Results showed that dairy yogurt was the most preferred. Among plant protein ingredients, canola and hemp were the most and least preferred, respectively. Consumers rated each product on purchase intention, environmental friendliness, and other attributes through a comprehensive questionnaire. Findings indicated significant variation in purchase intentions based on product and protein type. Canola‐based products were seen as more environmentally friendly compared to soy. Attributes such as ‘Healthy’, ‘Contains calcium’, and ‘Contains proteins’ positively affected purchase intentions, while negative perceptions about flavour impacted intentions adversely. Cluster analysis revealed significant differences across clusters regarding protein preferences and product types.
Design and construction of in vitro digestive simulation model
Authors: Li Yan , Yuan Zihong , Shi Aliu , Xiang Zhiyuan , Zhang Huaping 
Published: September 2024

SummaryThe utilisation of in vitro digestive simulation models holds significant importance in the development, quality control, and safety evaluation of functional foods. This review presents an overview of the classification, design, and construction methods of in vitro digestive models while summarising the emerging trends towards miniaturisation and intelligence. Miniaturisation technology enhances the ability of these models to simulate physiological processes within the human digestive system more accurately, thereby improving experiment repeatability and controllability. Intelligent technology further facilitates optimal design, data collection, and analysis for in vitro digestive models.
Assessment of the synergy degree of China's food safety risk governance policy tools based on text mining and machine learning methods
Authors: Sha Di , Qin Ke , Zhu Lv , Qian He , Wu Linhai 
Published: September 2024

SummaryImplementing proactive and effective policy tools is essential for governments to manage food safety risks. Existing studies have overlooked the synergistic effects among policy tools for governing food safety risks in China. This study uses policy tool synergy to develop a quantitative model to evaluate the degree of synergy among policy tools for food safety risk governance by considering its vertical, horizontal, and temporal dimensions. Using the Top2Vec topic model and text mining techniques, we examined 558 policy documents implemented by the central and six provincial governments. The findings reveal that China's food safety risk governance system has established a collaborative mechanism, with the Administration for Market Regulation, the Department of Agriculture and Rural Affairs, and the Health Commission playing crucial roles in policy implementation. Vertical and horizontal synergies between the upper and lower levels of government and among departments at the same level are crucial for enhancing comprehensive synergy.
Low‐field nuclear magnetic resonance relaxometry: a new approach for monosaccharide identification in sugar solutions
Authors: Asghari Ali , Sultana Afroza , Khalloufi Seddik 
Published: September 2024

SummaryMonosaccharides such as glucose, fructose, and galactose are the building blocks of oligosaccharides and act as the major energy sources in our body. These three monosaccharides are the most prominent in food processing and widely consumed analytes, found in fruits or milk. Although several analytical methods are available to identify and quantify sugar solutions, their drawbacks urge the search for better possible alternatives. A simple, rapid, and efficient method for identifying monosaccharides (ᴅ‐fructose, ᴅ‐galactose, and ᴅ‐glucose) was investigated using low‐field nuclear magnetic resonance (LF‐NMR), exploring the applicability and reliability of this machine. The transverse (T2) relaxation curve was analysed to distinguish monosaccharides from each other. The increasing monosaccharide concentration in the sugar solution causes leftward shifts in signals, indicating a gradual reduction in the mobility of water molecules. The addition of sugar generated a secondary peak, which assisted in identifying monosaccharides. Notably, fructose exhibited distinct behaviour from that of glucose and galactose. The regression coefficient consistently exceeded 0.98, indicating the reliability of this experiment. LF‐NMR encountered challenges in differentiating stereo‐isomeric glucose and galactose. However, quantification of monosaccharides from known binary mixtures (water and one monosaccharide) is possible by preparing standard curves of different concentrations of sugars. These standard curves can be either T2 or the total surface area of the peaks as a function of sugar concentration. The study concludes that LF‐NMR has potential for the qualitative and quantitative analysis of monosaccharides in pure solutions or powdered samples. It is hoped that the rapid and easy way of monosaccharide identification by simple analysis of peaks obtained from NMR spectra will enhance its accessibility for users. However, it also acknowledges limitations in applying this method to complex systems (mixtures of different sugars in a solution).
Delta Immature Platelet Fraction Is Associated With Mortality in Bacteremia Patients
Authors: Shih Pei‐Chun , Wang Yi‐Hua , Chen Shey‐Ying , Tseng Min , Hsu Cheng‐An , Yang Ming‐Yan , Wang Hsin‐Yao , Lee Jia‐Arng 
Published: September 2024

ABSTRACTObjectivesImmature platelet fraction (IPF) for differentiating bacteremia has been explored, whereas its prognostic correlation remains uncertain. This study aims to confirm the predictive capability of IPF for bacteremia and investigate its association with prognosis.MethodsPatients with complete blood count (CBC) on the blood culture day (D1) and the preceding day (D0) were retrospectively recruited and categorized into bacteremia and nonbacteremia groups. Immature platelet (IP) analysis, alongside CBC, was conducted. Delta IPF, defined by the absolute values of D1 minus D0 results was calculated. The ability to distinguish bacteremia from nonbacteremia patients, and the correlation with mortality were analyzed.ResultsFrom February to December 2020, a total of 150 patients were enrolled, with 75 having bacteremia. The specificity for delta IPF ≥3.4% to predict bacteremia was 97.3% (95% confidence interval [CI]: 90.7–99.7). When delta IPF ≥3.4% combined with procalcitonin ≥0.5 (ng/mL), the sensitivity was 90.5% (95% CI: 69.6%–98.8%). Within the bacteremia group, delta IPF and the proportion of patients with delta IPF ≥1.5% were significantly higher in nonsurvival, while delta platelet levels did not. Furthermore, delta IPF ≥1.5% was independently associated with 30‐day mortality (adjusted odds ratio: 3.88, 95% CI: 1.2%–11.4%; p = 0.020). The 30‐day survival curve demonstrated a significant difference between patients with delta IPF ≥1.5% and those without (p < 0.001).ConclusionsDelta IPF correlates with mortality in bacteremia patients. Our findings suggest IPF not only helps detect bacteremia but also predicts prognosis in the early stage.
Networks of persistence: A new framework for protracted displacement from a Georgian lens
Authors: Dmello Jared R. , Mitchneck Beth 
Published: September 2024

AbstractMillions of internally displaced people are living in their own countries in a temporary status called ‘protracted displacement’, a term not without its debates. We use a social network analysis database to assess how social interactions and demographic characteristics, including the relative location of resettlement, may contribute to IDP integration during the first 2 years of displacement. Our analysis of information from 57 internally displaced individuals in the aftermath of the 2008 Russo‐Georgian War, finds that networks of persistence, rather than survival or integration, characterize patterns of protracted displacement within 2 years of displacement. This suggests a need for rethinking the mainstream definitions to ensure vital resources are provided to displaced populations to promote timely integration.
Effects of pollination and plant genotype on Ustilago maydis disease development on the ears of maize inbreds and maize‐teosinte near‐isogenic lines
Authors: Bhatta Usha , Smith Shavannor M. 
Published: September 2024

AbstractUstilago maydis, the fungus that causes corn smut disease, leads to significant economic losses in maize cultivars. A key feature of successful plant pathogens is their ability to utilize the plant–pathogen relationship to influence disease progression. Greenhouse experiments examined how pollination and plant genotype affect disease incidence and severity of U. maydis infection. Four U. maydis susceptible maize inbreds (B73, H95, Mo17, and Golden Bantam), and two U. maydis resistant maize‐teosinte near‐isogenic lines (NIL1 and NIL2) were utilized for this work. Three‐hundred and sixty plants (pollinated and unpollinated) from the six plant genotypes were inoculated with U. maydis and assessed based on five phenotypic traits [(1) disease incidence, (2) gall number, (3) gall weight, (4) disease severity, and (5) area under disease progress curve]. All pollinated plants demonstrated significantly (p < .001) lower disease incidence, gall number, gall weight, area under the disease progress curve, and severity in comparison to the unpollinated plants. Both pollinated resistant NILs demonstrated significantly (p < .001) less disease development than the pollinated susceptible maize plants and two unpollinated NILs. Therefore, disease resistance to U. maydis was dependent upon pollination and plant genotype. This provides novel evidence that pollination can significantly improve resistance to U. maydis in different plant genotypes. Enhanced disease resistance observed in the resistant NILs after pollination indicates pollination‐mediated resistance is one of the resistance mechanisms functioning in the resistant NILs. Integration of pollination‐mediated resistance and resistance introgressed from a maize progenitor will be useful for improving resistance to U. maydis and management of the disease.
Genetic Diversity and Response of Melon Accessions toMonosporascus cannonballus
Authors: de Freitas Sabrina Queiroz , Negreiros Andréia Mitsa Paiva , de Sousa Nunes Glauber Henrique , Cavalcante Allinny Luzia Alves , Santos Fernanda Jessica Queiroz , Viana Dariane Monteiro , de Assis Melo Naama Jessica , Sales Júnior Rui 
Published: September 2024

ABSTRACTMelon holds significant economic importance for Brazilian agribusiness. It exhibits high polymorphism and genetic variability, yet knowledge regarding its genetic diversity and response to root diseases remains limited. Therefore, this study aimed to assess the genetic diversity and response of melon plant accessions to Monosporascus cannonballus. Two trials were conducted involving 29 melon accessions and a commercial hybrid of the yellow melon plant, Natal RZ. In the first trial, the accessions and the commercial hybrid were grown in the field under a randomised complete block design with three replications. They were evaluated for fruit‐related descriptors: number of fruits per plant (NFP), average fruit weight, shape index, pulp thickness, pulp firmness (PF) and total soluble solids (TSS). Standardised Euclidean distances were calculated on the basis of the results, and the accessions were grouped using the UPGMA method. In the second trial, the melon plant accessions and commercial hybrid were cultivated in a greenhouse under a completely randomised design with 12 replications. For inoculation, wheat grains infested with M. cannonballus isolate CMM‐2429 were used. Evaluations were conducted 60 days after transplanting, assessing the incidence and severity of the disease, and biometric variables. The study revealed genetic variability among the evaluated accessions for fruit descriptors and response to M. cannonballus. Most divergent accessions were A16, A53, NZR, A28, A51 and A44, with divergence primarily observed in NFP, PF and TSS. Promising accessions for breeding programmes aimed at resistance to M. cannonballus included A01, A04, A25, A27 (moderately resistant) and A26 (highly resistant to the pathogen).
Assessing the Compatibility of Streptomyces saraceticus With Pesticides and the Efficacy in Controlling Root‐Knot Nematode
Authors: Chen Ying‐Yu , Tsay Tung‐Tsuan , Chen Peichen 
Published: September 2024

ABSTRACTStreptomyces saraceticus strain 31 (SS31) exhibits antagonistic activities against a variety of phytopathogenic bacteria, fungi and nematodes. In our effort to integrate SS31 into an effective pest management programme for controlling plant pathogens, we assessed the toxicities of 74 pesticides commonly employed in agricultural production on SS31 using paper disc assays. Most of the test insecticides, acaricides, nematicides and plant growth regulators showed no antagonistic effects towards SS31. However, all six tested herbicides, glyphosate, paraquat, glufosinate‐ammonium, quizalofop‐ethyl, pendimthalin and butralin exerted strong inhibitory effects on SS31. Among the 42 tested fungicides, half of them, including acid amides, strobilurins, carbamates, antibiotics and morphine displayed no detrimental effects on SS31. Notably, copper‐based fungicides demonstrated high toxicity to SS31. Although chlorothalonil and thiophanate methyl + streptomycin displayed inhibitory effects on SS31, applying these pesticides with SS31 in pot tests resulted in a lower Meloidogyne incognita galling index compared with the mock control under greenhouse conditions. Additionally, applying SS31 with carbofuran or ethoprop effectively controlled M. incognita. These findings can provide strategies to refine application timing and enhance the beneficial effects of SS31.