bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective governance of food safety regulation across EU Member States: Towards operationalization
Authors: BAZZAN Giulia 
Published: October 2017

AbstractThis article seeks to make a contribution to the food safety regulation literature, and to the broader framework of risk regulation, in the attempt to establish both theoretically and empirically what can be intended as effective governance of food safety regulation. The aim is to review existing measures of effectiveness of food safety governance, and to give a preliminary definition of effectiveness, together with a theoretical perspective on how to operationalise it, eventually proposing an empirical measurement. Effectiveness of food safety governance can be measured – on the one hand – as the capacity of consumers’ protection, and thus, as the minimisation of risk related to food, and – on the other hand – as the capacity of protection of producers’ interests, in order to ensure competitiveness within the market. Distinguishing food safety delivered from food safety perceived, the article seeks to analyse dimensions of effectiveness related to both the protection of consumers and producers, and to the minimisation of risk, drawing upon Elinor Ostrom’s Institutional Analysis and Development Framework (IAD) and, particularly, her conceptualisation of opportunistic behaviour.
Institutional Reform and Violence Reduction in Pernambuco, Brazil
Authors: HOELSCHER KRISTIAN 
Published: October 2017

AbstractIf institutions are important for regulating violence, can institutional reforms make societies less violent? This article examines the north-east Brazilian state of Pernambuco primarily between 2007 and 2013, proposing that patterns of declining lethal violence can be explained by changes in both the accountability and effectiveness of formal state institutions and informal social norms. Drawing on two months of qualitative fieldwork, findings suggest that social and political mobilisation enabled a political coalition to initiate substantial changes under the Pacto pela Vida (Pact for Life) public-security programme, which improved the legitimacy and operational effectiveness of the criminal justice system, and coincided with a marked reduction in homicide rates. While showing that these reforms were central in reducing lethal violence in Pernambuco between 2007 and 2013, the article concludes by discussing the challenges of policy continuity in light of increasing rates of lethal violence since 2014.
Treating depression with physical activity in adolescents and young adults: a systematic review and meta-analysis of randomised controlled trials
Authors: Bailey A. P. , Hetrick S. E. , Rosenbaum S. , Purcell R. , Parker A. G. 
Published: October 2017

AbstractWe aimed to establish the treatment effect of physical activity for depression in young people through meta-analysis. Four databases were searched to September 2016 for randomised controlled trials of physical activity interventions for adolescents and young adults, 12–25 years, experiencing a diagnosis or threshold symptoms of depression. Random-effects meta-analysis was used to estimate the standardised mean difference (SMD) between physical activity and control conditions. Subgroup analysis and meta-regression investigated potential treatment effect modifiers. Acceptability was estimated using dropout. Trials were assessed against risk of bias domains and overall quality of evidence was assessed using GRADE criteria. Seventeen trials were eligible and 16 provided data from 771 participants showing a large effect of physical activity on depression symptoms compared to controls (SMD = −0.82, 95% CI = −1.02 to −0.61,p< 0.05,I2= 38%). The effect remained robust in trials with clinical samples (k= 5, SMD = −0.72, 95% CI = −1.15 to −0.30), and in trials using attention/activity placebo controls (k= 7, SMD = −0.82, 95% CI = −1.05 to −0.59). Dropout was 11% across physical activity arms and equivalent in controls (k= 12, RD = −0.01, 95% CI = −0.04 to 0.03,p= 0.70). However, the quality of RCT-level evidence contributing to the primary analysis was downgraded two levels to LOW (trial-level risk of bias, suspected publication bias), suggesting uncertainty in the size of effect and caution in its interpretation. While physical activity appears to be a promising and acceptable intervention for adolescents and young adults experiencing depression, robust clinical effectiveness trials that minimise risk of bias are required to increase confidence in the current finding. The specific intervention characteristics required to improve depression remain unclear, however best candidates given current evidence may include, but are not limited to, supervised, aerobic-based activity of moderate-to-vigorous intensity, engaged in multiple times per week over eight or more weeks. Further research is needed. (Registration: PROSPERO-CRD 42015024388).
Effects of childhood trauma on left inferior frontal gyrus function during response inhibition across psychotic disorders
Authors: Quidé Y. , O'Reilly N. , Watkeys O. J. , Carr V. J. , Green M. J. 
Published: October 2017

AbstractBackgroundChildhood trauma is a risk factor for psychosis. Deficits in response inhibition are common to psychosis and trauma-exposed populations, and associated brain functions may be affected by trauma exposure in psychotic disorders. We aimed to identify the influence of trauma-exposure on brain activation and functional connectivity during a response inhibition task.MethodsWe used functional magnetic resonance imaging to examine brain function within regions-of-interest [left and right inferior frontal gyrus (IFG), right dorsolateral prefrontal cortex, right supplementary motor area, right inferior parietal lobule and dorsal anterior cingulate cortex], during the performance of a Go/No-Go Flanker task, in 112 clinical cases with psychotic disorders and 53 healthy controls (HCs). Among the participants, 71 clinical cases and 21 HCs reported significant levels of childhood trauma exposure, while 41 clinical cases and 32 HCs did not.ResultsIn the absence of effects on response inhibition performance, childhood trauma exposure was associated with increased activation in the left IFG, and increased connectivity between the left IFG seed region and the cerebellum and calcarine sulcus, in both cases and healthy individuals. There was no main effect of psychosis, and no trauma-by-psychosis interaction for any other region-of-interest. Within the clinical sample, the effects of trauma-exposure on the left IFG activation were mediated by symptom severity.ConclusionsTrauma-related increases in activation of the left IFG were not associated with performance differences, or dependent on clinical diagnostic status; increased IFG functionality may represent a compensatory (overactivation) mechanism required to exert adequate inhibitory control of the motor response.
Inequality in active ageing: evidence from a new individual-level index for European countries
Authors: BARSLUND MIKKEL , VON WERDER MARTEN , ZAIDI ASGHAR 
Published: October 2017

ABSTRACTIn the context of emerging challenges and opportunities associated with population ageing, the study of inequality in active-ageing outcomes is critical to the design of appropriate and effective social policies. While there is much discussion about active ageing at the aggregate country level, little is known about inequality in active-ageing experiences within countries. Based on the existing literature on active ageing, this paper proposes an individual-level composite active ageing index based on Survey of Health, Ageing and Retirement in Europe (SHARE) data. The individual-level nature of the index allows us to analyse inequality in experiences of active ageing within selected European countries. One important motivation behind measuring active ageing at the individual level is that it allows for a better understanding of unequal experiences of ageing, which may otherwise be masked in aggregate-level measures of active ageing. Results show large differences in the distribution of individual-level active ageing across the 13 European countries covered and across age groups. Furthermore, there is a positive association between the country-level active ageing index and the equality of its distribution within a country. Hence, countries with the lowest average active ageing index tend to have the most unequal distribution in active-ageing experiences. For nine European countries, where temporal data are also available, we find that inequality in active-ageing outcomes decreased in the period 2004 to 2013.
Weight resilience and fruit and vegetable intake among African-American women in an obesogenic environment
Authors: Parisi Sara M , Bodnar Lisa M , Dubowitz Tamara 
Published: October 2017

AbstractObjectiveTo investigate relationships between weight resilience (maintaining a normal weight in a food desert environment) and fruit and vegetable (F&V) intake, attitudes and barriers.DesignCross-sectional, in-person surveys collected May–December 2011, including self-reported data on F&V-related psychosocial factors, attitudes and barriers. Two 24 h dietary recalls were completed; weight and height were measured. Multivariable regression models estimated prevalence ratios (95 % CI).SettingTwo low-income, predominantly African-American food deserts in Pittsburgh, Pennsylvania, USA.SubjectsWomen aged 18–49 years (n279) who were the primary food shopper in a household randomly selected for a parent study.ResultsFifteen per cent were weight resilient, 30 % were overweight and 55 % were obese. Overall, 25 % reported eating ≥5 F&V servings/d. After adjustment for age, education, parity, employment, living alone, physical activity, per capita income and mean daily energy intake, women eating ≥5 F&V servings/d were 94 % more likely to be weight resilient compared with those eating <5 servings/d (1·94; 1·10, 3·43). Across BMI groups, self-efficacy regarding F&V consumption was high and few F&V barriers were reported. The most frequently reported barrier was concern about the cost of F&V (36 %). Of the attitudinal F&V-related factors, only concern about wasting food when serving F&V was associated with weight resilience in adjusted models (0·29; 0·09, 0·94). In a model predicting consuming ≥5 F&V servings/d, driving one’s own car to the store was the only attitudinal F&V-related factor associated with consumption (1·50; 1·00, 2·24).ConclusionsIn this population, weight resilience may be encouraged by improving access to affordable and convenient F&V options and providing education on ways to make them palatable to the entire household, rather than by shifting women’s F&V perceptions, which are already positive.
A qualitative study conducted in the USA exploring Latino fathers’ beliefs, attitudes and practices related to their young children’s eating, physical activity and sedentary behaviours
Authors: Lindsay Ana Cristina , Wallington Sherrie F , Muñoz Mario A , Greaney Mary L 
Published: October 2017

AbstractObjectiveIncreasing evidence documents fathers’ influential role in their children’s eating, physical activity (PA) and sedentary behaviours (SB). We aimed to expand limited existing research examining fathers’ influence in these areas by exploring Latino fathers’ beliefs, attitudes and practices related to eating, PA and SB of their young children.DesignSeven focus group discussions were conducted in Spanish with Latino fathers (n 28) of children aged 2–8 years. Audio recordings were transcribed and translated verbatim without identifiers. Data were analysed using thematic analysis to identify key concepts and themes using NVivo 11 software.ResultsFathers expressed positive beliefs and attitudes about the importance of healthy eating for their young children, themselves and their families. Nevertheless, the majority reported familial practices including eating out, getting take-out, etc. that have been linked to increased obesity risk among Latino children. Fathers were more involved and engaged in children’s PA than eating and feeding. However, several fathers reported engaging predominantly in sedentary activities with their children, appeared permissive of children’s sedentary habits and struggled to set limits on children’s screen-time.ConclusionsWe provide new information on Latino fathers’ beliefs and child feeding and PA practices that may provide important targets for interventions aimed at promoting healthful eating and PA behaviours of Latino children. Future research should further quantify the influence of Latino fathers’ parenting styles and practices on development of children’s eating, PA and SB. This information is needed to identify risk factors amenable to interventions and to design culturally appropriate parenting and family-based interventions targeting Latino children’s home environment and designed to meet this ethnic group’s specific needs.
Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors
Authors: Wang Bo , Fu Xing , Liang Xingwei , Deavila Jeanene M , Wang Zhixiu , Zhao Liang , Tian Qiyu , Zhao Junxing , Gomez Noe Alberto , Trombetta Sophie C , Zhu Mei-Jun , Du Min 
Published: October 2017

AbstractFormation of beige adipocytes within white adipose tissue enhances energy expenditure, which is a promising strategy to reduce obesity and prevent metabolic symptoms. Vitamin A and its bioactive metabolite, retinoic acid (RA), have regulatory roles in lipid metabolism. Here we report that RA induces white adipose tissue browning via activating vascular endothelial growth factor (VEGF) signaling. RA triggered angiogenesis and elicited de novo generation of platelet-derived growth factor receptor α positive (PDGFRα+) adipose precursor cells via VEGFA/VEGFR2 signaling. In addition, RA promoted beige/brown adipocyte formation from capillary networks in vitro. Using PDGFRα tracking mice, we found that the vascular system acted as an adipogenic repository by containing PDGFRα+ progenitors which differentiated into beige adipocytes under RA or VEGF164 treatments. Conditional knockout of VEGF receptors blocked RA-stimulated white adipose tissue browning. Moreover, the VEGFA and RA activated p38MAPK to enhance the binding of RA receptor to RA response elements of the Prdm16 promoter and upregulated Prdm16 transcription. In conclusion, RA induces white adipose tissue browning by increasing adipose vascularity and promoting beige adipogenesis of PDGFRα+ adipose progenitors.
The impact of rare variation on gene expression across tissues
Authors:   GTEx Consortium, Li Xin , Kim Yungil , Tsang Emily K. , Davis Joe R. , Damani Farhan N. , Chiang Colby , Hess Gaelen T. , Zappala Zachary , Strober Benjamin J. , Scott Alexandra J. , Li Amy , Ganna Andrea , Bassik Michael C. , Merker Jason D. , Hall Ira M. , Battle Alexis , Montgomery Stephen B. 
Published: October 2017

AbstractRare genetic variants are abundant in humans and are expected to contribute to individual disease risk1,2,3,4. While genetic association studies have successfully identified common genetic variants associated with susceptibility, these studies are not practical for identifying rare variants1,5. Efforts to distinguish pathogenic variants from benign rare variants have leveraged the genetic code to identify deleterious protein-coding alleles1,6,7, but no analogous code exists for non-coding variants. Therefore, ascertaining which rare variants have phenotypic effects remains a major challenge. Rare non-coding variants have been associated with extreme gene expression in studies using single tissues8,9,10,11, but their effects across tissues are unknown. Here we identify gene expression outliers, or individuals showing extreme expression levels for a particular gene, across 44 human tissues by using combined analyses of whole genomes and multi-tissue RNA-sequencing data from the Genotype-Tissue Expression (GTEx) project v6p release12. We find that 58% of underexpression and 28% of overexpression outliers have nearby conserved rare variants compared to 8% of non-outliers. Additionally, we developed RIVER (RNA-informed variant effect on regulation), a Bayesian statistical model that incorporates expression data to predict a regulatory effect for rare variants with higher accuracy than models using genomic annotations alone. Overall, we demonstrate that rare variants contribute to large gene expression changes across tissues and provide an integrative method for interpretation of rare variants in individual genomes.
Advances in the physiological assessment and diagnosis of GERD
Authors:   on behalf of the International Working Group for Disorders of Gastrointestinal Motility and Function, Savarino Edoardo , Bredenoord Albert J. , Fox Mark , Pandolfino John E. , Roman Sabine , Gyawali C. Prakash 
Published: October 2017

AbstractGERD is a common condition worldwide. Key mechanisms of disease include abnormal oesophagogastric junction structure and function, and impaired oesophageal clearance. A therapeutic trial of acid-suppressive PPI therapy is often the initial management, with endoscopy performed in the setting of alarm symptoms and to exclude other conditions. If symptoms persist and endoscopy does not reveal evidence of GERD, oesophageal function tests are performed, including oesophageal manometry and ambulatory reflux monitoring. However, reflux episodes can be physiological, and some findings on endoscopy and manometry can be encountered in asymptomatic individuals without GERD symptoms. The diagnosis of GERD on the basis of functional oesophageal testing has been previously reported, but no updated expert recommendations on indications and the interpretation of oesophageal function testing in GERD has been made since the Porto consensus over a decade ago. In this Consensus Statement, we aim to describe modern oesophageal physiological tests and their analysis with an emphasis on establishing indications and consensus on interpretation parameters of oesophageal function testing for the evaluation of GERD in clinical practice. This document reflects the collective conclusions of the international GERD working group, incorporating existing data with expert consensus opinion.
Anomalous Kondo resonance mediated by semiconducting graphene nanoribbons in a molecular heterostructure
Authors: Li Yang , Ngo Anh T. , DiLullo Andrew , Latt Kyaw Zin , Kersell Heath , Fisher Brandon , Zapol Peter , Ulloa Sergio E. , Hla Saw-Wai 
Published: October 2017

AbstractKondo resonances in heterostructures formed by magnetic molecules on a metal require free host electrons to interact with the molecular spin and create delicate many-body states. Unlike graphene, semiconducting graphene nanoribbons do not have free electrons due to their large bandgaps, and thus they should electronically decouple molecules from the metal substrate. Here, we observe unusually well-defined Kondo resonances in magnetic molecules separated from a gold surface by graphene nanoribbons in vertically stacked heterostructures. Surprisingly, the strengths of Kondo resonances for the molecules on graphene nanoribbons appear nearly identical to those directly adsorbed on the top, bridge and threefold hollow sites of Au(111). This unexpectedly strong spin-coupling effect is further confirmed by density functional calculations that reveal no spin–electron interactions at this molecule-gold substrate separation if the graphene nanoribbons are absent. Our findings suggest graphene nanoribbons mediate effective spin coupling, opening a way for potential applications in spintronics.
Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
Authors: Lee Jong-Ho , Liu Rui , Li Jing , Zhang Chuanbao , Wang Yugang , Cai Qingsong , Qian Xu , Xia Yan , Zheng Yanhua , Piao Yuji , Chen Qianming , de Groot John F. , Jiang Tao , Lu Zhimin 
Published: October 2017

AbstractPhosphofructokinase 1 (PFK1) plays a critical role in glycolysis; however, its role and regulation in tumorigenesis are not well understood. Here, we demonstrate that PFK1 platelet isoform (PFKP) is the predominant PFK1 isoform in human glioblastoma cells and its expression correlates with total PFK activity. We show that PFKP is overexpressed in human glioblastoma specimens due to an increased stability, which is induced by AKT activation resulting from phosphatase and tensin homologue (PTEN) loss and EGFR-dependent PI3K activation. AKT binds to and phosphorylates PFKP at S386, and this phosphorylation inhibits the binding of TRIM21 E3 ligase to PFKP and the subsequent TRIM21-mediated polyubiquitylation and degradation of PFKP. PFKP S386 phosphorylation increases PFKP expression and promotes aerobic glycolysis, cell proliferation, and brain tumor growth. In addition, S386 phosphorylation in human glioblastoma specimens positively correlates with PFKP expression, AKT S473 phosphorylation, and poor prognosis. These findings underscore the potential role and regulation of PFKP in human glioblastoma development.
NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
Authors: Wang Jianrong , He Nanhai , Zhang Na , Quan Dexian , Zhang Shuo , Zhang Caroline , Yu Ruth T. , Atkins Annette R. , Zhu Ruihong , Yang Chunhui , Cui Ying , Liddle Christopher , Downes Michael , Xiao Hui , Zheng Ye , Auwerx Johan , Evans Ronald M. , Leng Qibin 
Published: October 2017

AbstractThymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and maturation of thymocytes whose TCRs display intermediate affinity to self pMHCs for effective immunity, but whether transcriptional regulation helps conserve positively selected thymocytes from being purged by negative selection remains unclear. Here we show that the specific deletion of nuclear receptor co-repressor 1 (NCoR1) in T cells causes excessive negative selection to reduce mature thymocyte numbers. Mechanistically, NCoR1 protects positively selected thymocytes from negative selection by suppressing Bim expression. Our study demonstrates a critical function of NCoR1 in coordinated positive and negative selections in the thymus.
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
Authors: Xu Yiming , Wang Yong , Yan Siyuan , Yang Qiuhua , Zhou Yaqi , Zeng Xianqiu , Liu Zhiping , An Xiaofei , Toque Haroldo A. , Dong Zheng , Jiang Xuejun , Fulton David J. , Weintraub Neal L. , Li Qinkai , Bagi Zsolt , Hong Mei , Boison Detlev , Wu Chaodong , Huo Yuqing 
Published: October 2017

AbstractThe molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial intracellular adenosine and its key regulator adenosine kinase (ADK) play important roles in vascular inflammation. Pro-inflammatory stimuli lead to endothelial inflammation by increasing endothelial ADK expression, reducing the level of intracellular adenosine in endothelial cells, and activating the transmethylation pathway through increasing the association of ADK with S-adenosylhomocysteine (SAH) hydrolase (SAHH). Increasing intracellular adenosine by genetic ADK knockdown or exogenous adenosine reduces activation of the transmethylation pathway and attenuates the endothelial inflammatory response. In addition, loss of endothelial ADK in mice leads to reduced atherosclerosis and affords protection against ischemia/reperfusion injury of the cerebral cortex. Taken together, these results demonstrate that intracellular adenosine, which is controlled by the key molecular regulator ADK, influences endothelial inflammation and vascular inflammatory diseases.