bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do we need more AHP/ANP studies?
Authors: Mu Enrique 
Published: December 2016

Recently, a paper submitted to a major journal was rejected by the editor with the indication that the AHP method was very well known so “another AHP study” was not needed for the time being. Being a scholar publishing also in areas beyond AHP/ANP, I was quite surprised by the argument. I have never seen a paper being rejected with the argument that “Structural Equation Modeling (SEM) is a well known method so we do not need “another SEM study.”
Contratación “on line” de servicios turísticos y paquetes dinámicos de turismo
Authors: Asensi Meras Altea 
Published: December 2016

La implementación de las nuevas tecnologías o TIC’s en el sector turístico se ha visto favorecida, en los últimos años, por las posibilidades que Internet ofrece de poder comprobar instantáneamente la existencia real del proveedor del servicio, la veracidad del servicio prestado o las condiciones en que se presta. El aumento de la contratación electrónica de servicios turísticos exige que los proveedores de estos servicios y los turistas tengan en cuenta las diferentes normas jurídicas que resultan de aplicación en el ámbito de los servicios de la sociedad de la información, principalmente, la Ley 34/2002, de 11 de julio, de Servicios de la Sociedad de la Información y de Comercio Electrónico (LSSI), las normas reguladoras del consumo. Por otra parte, la nueva Directiva 2015/2302 del Parlamento Europeo y del Consejo, de 25 de noviembre de 2015, relativa a los viajes combinados y a los servicios de viaje vinculados ofrece una nueva regulación aplicable a los viajes combinados y a los denominados “servicios de viaje combinado” que resultan de aplicación a las nuevas formas de contratación on line de servicios turísticos.
Redes sociales virtuales en la comunicación corporativa del IBEX 35: usos, desarrollo e importancia según sus responsables
Authors: Durántez Stolle Patricia 
Published: December 2016

Los medios sociales ofrecen una oportunidad para la comunicación corporativa en el contexto de la Web 2.0, donde la imagen y reputación se ven afectadas por las conversaciones de las comunidades digitales. Las investigaciones previas sobre esta cuestión, basadas en análisis de contenido, señalan el interés de las empresas por tener presencia corporativa en redes sociales, pero destacan la falta de aprovechamiento de las posibilidades interactivas y dialógicas. El propósito de este artículo consiste en mostrar, mediante una encuesta, la opinión de los departamentos de comunicación de las grandes empresas españolas sobre las redes sociales. Los objetivos incluyen conocer los perfiles profesionales responsables de la planificación y gestión de la presencia corporativa en redes, comprender sus usos e importancia y observar cómo responden ante la posibilidad de establecer relaciones dialógicas con sus públicos. Los resultados muestran que las empresas del IBEX 35 consideran fundamentales sus perfiles corporativos en redes sociales, su actualización frecuente y gestión profesionalizada. Además, entienden su carácter conversacional, sin embargo, los emplean principalmente para informar. Así, se observa la falta de coherencia entre la comprensión del contexto dialógico, la importancia concedida a las redes sociales y los usos informativos que priman en la mayoría de casos.
Prehranjevalne navade in telesna aktivnost dijakov primorsko-notranjske regije
Authors: Radivo Manica , Pucer Patrik , Poklar Vatovec Tamara 
Published: December 2016

Uvod: Zdrava prehrana in telesna aktivnost sta neločljivo povezani določilnici zdravja mladostnikov. Namen raziskave je bil (1) ovrednotiti prehranski status ter prehranjevalne navade dijakov 3. letnikov srednješolskega izobraževanja v primorsko-notranjski regiji in (2) preučiti navade njihove telesne aktivnosti ter (3) raziskati povezavo med njihovimi indeksi telesne mase (kg/m2) in prehranskimi navadami.
Metode: Raziskava je bila opravljena spomladi 2015 na vzorcu dijakov 3. letnikov (n = 166) v primorskonotranjski regiji. Njihova povprečna starost je bila 18,2 let. Uporabljen je bil anonimni spletni vprašalnik 1KA s 44 vprašanji. S programom SPSS verzija 22 je bila izvedena opisna in inferenčna statistika.
Rezultati: Dijaki ne uživajo sadja in zelenjave vsak dan (74 % fantov in 63 % deklet), pri čemer je primanjkljaj skupnega vnosa zelenjave (fantje: 151,3 g, dekleta: 166,7 g) in stročnic (fantje: 138,2 g, dekleta: 141,8 g) večji, kot je pri vnosu sadja (fantje: 172,4 g, dekleta: 170,9 g). Tudi uživanje rib je glede na priporočila premajhno, priporočene količine dosega le 5,4 % deklet in 4,5 %. Dijaki tudi niso dovolj telesno aktivni.
Diskusija in zaključek: Kljub številnim ukrepom prehranske politike je med dijaki še vedno premajhen vnos sadja in zelenjave. Šolski obroki bi morali pogosteje vsebovati zelenjavo, stročnice in ribe. Za spodbujanje telesne aktivnosti bi morali mladim šport približati kot vrednoto, dostopno vsem mladostnikom.
Nursing students’ knowledge levels about nanotechnology and factors influencing knowledge levels<p>Hemşirelik öğrencilerinin nanoteknoloji bilgi düzeyleri ve bilgi düzeylerini etkileyen faktörler
Authors: Aydın Sayılan Aylin , Mercan Yeliz 
Published: December 2016

Aim: The aimed of the study determine the nursing students’ knowledge levels about nanotechnology and factors influencing knowledge levels.Method: This cross sectional research is study with 283 nursing students and there isn’t sample selection.The questionnaires developed by the researchers for assessment level of knowledge about nanotechnology and data were collected by face-to-face methods. In the analysis, we used SPSS 22.0 package program and chikare , logistic regression analysis were used.The level of significance was accepted as p<0.05.As the level of mother education increased, the students' knowledge level of nanotechnology increased nearly 1.2% -1.5% (p <0.05).If students use internet for follow up the scientific world the level of knowledge about nanotechnology increased nearly 1,0%.It has been determined that there isn’t any knowledge of the students about related fields in health a rate of 38.9% -59.0%.Nursing students have inadequate knowledge on the concept of nanotechnology which use in healthcare.It was suggested that the topic of nanotechnology should be included in the course content parallel to evolving and changing science. ÖzetAraştırmada, hemşirelik bölümü öğrencilerinin nanoteknoloji bilgi düzeylerini ve bunu etkileyen faktörleri belirlemek amaçlanmıştır.Kesitsel tipte gerçekleştirilen çalışmada, örnek seçimi yapılmamış, 283 hemşirelik öğrencisiyle gerçekleştirilmiştir. Veriler araştırmacılar tarafından geliştirilen anket yardımıyla yüzyüze görüşme yöntemiyle toplanmıştır. Çözümlemede SPSS 22.0 paket programı kullanılmış, kikare ve lojistik regresyon analizinden yararlanılmıştır. Anlamlılık düzeyi p<0,05 kabul edilmiştir. Çalışmada anne eğitim düzeyi arttıkça öğrencilerin nanoteknoloji bilgi düzeylerinin yaklaşık %1,2-%1,5 kat arttığı (p<0,05) belirlenmiştir. Bilim dünyasını takip etmek amacıyla internet kullanımı (yaklaşık %1,1 kat) ve kanser tedavisi alanlarında nanoteknoloji kullanımının (yaklaşık %1,0 kat) nanoteknoloji bilgi düzeyini anlamlı olarak (p<0,05) arttırdığı saptanmıştır. Öğrencilerin %38,9-%59,0 arasında değişen oranlarda sağlık ile ilgili alanlarda hiçbir fikri/bilgisi olmadığı belirlenmiştir.Hemşirelik öğrencileri nanoteknoloji kavramı ve sağlık alanındaki kullanım alanları konularında yetersiz bilgiye sahiptir. Gelişen ve değişen bilime paralel olarak nanoteknoloji konusunun ders içeriğinde yer alması gerekmektedir.
Histological evidence for reversible cardiomyocyte changes and serum cardiac troponin T elevation after exercise in rats
Authors: Nie Jinlei , George Keith , Duan Fei , Tong Tomas K. , Tian Ye 
Published: December 2016

AbstractThis study characterized cardiac troponin T (cTnT) appearance and associated histological evidence of reversible or irreversible changes in myocardial ultrastructure, determined via electron microscopy, in rats undertaking isoproterenol (ISO) infusion or an endurance exercise challenge. Male rats were randomized into ISO and exercise groups. In ISO trials rats were killed 5 h (ISO‐5H) and 24 h (ISO‐REC19H) after a single ISO or saline injection (SAL‐5H; SAL‐REC19H). In the exercise trials rats were killed before, as a control (EXE‐CON), immediately after (EXE‐END5H) and 19 h after (EXE‐REC19H) a 5‐h bout of swimming with 5% body weight attached to their tail. Serum cTnT was quantified by electrochemiluminescence, and myocardial samples in ISO‐REC19H, EXE‐REC19H and SAL‐REC19H were harvested for assessment of specific mitochondrial injury scores using electron‐microscopy. cTnT was undetectable in all control animals (SAL‐5H/SAL‐REC19H and EXE‐CON). cTnT increased in all animals after ISO and exercise but the response was significantly higher (P < 0.05) at ISO‐5H (median [range]: 2.60 [1.76–6.18] μg · L−1) than at EXE‐END5H (median [range]: 0.05 [0.02–0.14] μg · L−1). cTnT returned to baseline at EXE‐REC19H, but had not completely recovered at ISO‐REC19H (median [range]: 0.17 [0.09–1.22] μg · L−1). Mitochondrial “injury scores” were significantly higher (P < 0.05) in ISO‐REC19H compared to EXE‐REC19H and SAL‐REC19H, with no difference between EXE‐REC19H and SAL‐REC19H. Mitochondria from EXE‐REC19H appeared aggregated in nonlinear clusters in a small number of scans. These findings suggest that acute exercise‐induced appearance of cTnT in this animal model is only associated with reversible changes in cardiomyocyte structure.
Plasma from exercised rats administered to sedentary rats induces systemic and tissue inflammation
Authors: Goutianos Georgios , Veskoukis Aristidis S. , Tzioura Aikaterini , Paschalis Vassilis , Margaritelis Nikos V. , Dipla Konstantina , Zafeiridis Andreas , Vrabas Ioannis S. , Nikolaidis Michalis G. , Kyparos Antonios 
Published: December 2016

AbstractRecent studies have consistently supported the active role of blood in mediating biochemical and physiological tissue adaptations. However, no study has investigated the possible contribution of circulating factors in an exercise setting. The aim of the study was to investigate the role of circulating factors in exercise adaptations by chronically administering to sedentary animals blood plasma collected from acutely exercised animals. Phase 1: Blood plasma was collected from rats that swam to exhaustion and from sedentary rats. Phase 2: Other rats were divided into two groups (n = 20 per group): the first group involved rats that were injected intravenously with blood plasma originating from rats that previously swam to exhaustion, the second group consisted of rats that were injected intravenously with blood plasma originating from sedentary rats. Tail‐vein injections (2 mL/kg) were performed daily for 21 consecutive days. Inflammatory markers (C‐reactive protein, interleukins‐1α, 2, 6, 8, 10 and tumor necrosis factor‐a) were measured in blood plasma, muscle, and adipose tissue. Sedentary rats administered with plasma from exercised rats had significantly higher levels in all inflammatory markers measured in blood, skeletal muscle and adipose tissue, compared to the sedentary rats administered with resting plasma. Our data demonstrate that administration of “exercised” blood to sedentary rats induced inflammation in plasma, muscle and adipose tissue. Exercise adaptations are not solely due to intrinsic processes in muscle or adipose tissue. Blood factors also play a crucial role in mediating signals for tissue adaptations.
Spatiotemporal Filter for Visual Motion Integration from Pursuit Eye Movements in Humans and Monkeys
Authors: Mukherjee Trishna , Liu Bing , Simoncini Claudio , Osborne Leslie C. 
Published: December 2016

Despite the enduring interest in motion integration, a direct measure of the space–time filter that the brain imposes on a visual scene has been elusive. This is perhaps because of the challenge of estimating a 3D function from perceptual reports in psychophysical tasks. We take a different approach. We exploit the close connection between visual motion estimates and smooth pursuit eye movements to measure stimulus–response correlations across space and time, computing the linear space–time filter for global motion direction in humans and monkeys. Although derived from eye movements, we find that the filter predicts perceptual motion estimates quite well. To distinguish visual from motor contributions to the temporal duration of the pursuit motion filter, we recorded single-unit responses in the monkey middle temporal cortical area (MT). We find that pursuit response delays are consistent with the distribution of cortical neuron latencies and that temporal motion integration for pursuit is consistent with a short integration MT subpopulation. Remarkably, the visual system appears to preferentially weight motion signals across a narrow range of foveal eccentricities rather than uniformly over the whole visual field, with a transiently enhanced contribution from locations along the direction of motion. We find that the visual system is most sensitive to motion falling at approximately one-third the radius of the stimulus aperture. Hypothesizing that the visual drive for pursuit is related to the filtered motion energy in a motion stimulus, we compare measured and predicted eye acceleration across several other target forms.SIGNIFICANCE STATEMENTA compact model of the spatial and temporal processing underlying global motion perception has been elusive. We used visually driven smooth eye movements to find the 3D space–time function that best predicts both eye movements and perception of translating dot patterns. We found that the visual system does not appear to use all available motion signals uniformly, but rather weights motion preferentially in a narrow band at approximately one-third the radius of the stimulus. Although not universal, the filter predicts responses to other types of stimuli, demonstrating a remarkable degree of generalization that may lead to a deeper understanding of visual motion processing.
Edge-Related Activity Is Not Necessary to Explain Orientation Decoding in Human Visual Cortex
Authors: Wardle Susan G. , Ritchie J. Brendan , Seymour Kiley , Carlson Thomas A. 
Published: December 2016

Multivariate pattern analysis is a powerful technique; however, a significant theoretical limitation in neuroscience is the ambiguity in interpreting the source of decodable information used by classifiers. This is exemplified by the continued controversy over the source of orientation decoding from fMRI responses in human V1. Recently Carlson (2014) identified a potential source of decodable information by modeling voxel responses based on the Hubel and Wiesel (1972) ice-cube model of visual cortex. The model revealed that activity associated with the edges of gratings covaries with orientation and could potentially be used to discriminate orientation. Here we empirically evaluate whether “edge-related activity” underlies orientation decoding from patterns of BOLD response in human V1. First, we systematically mapped classifier performance as a function of stimulus location using population receptive field modeling to isolate each voxel's overlap with a large annular grating stimulus. Orientation was decodable across the stimulus; however, peak decoding performance occurred for voxels with receptive fields closer to the fovea and overlapping with the inner edge. Critically, we did not observe the expected second peak in decoding performance at the outer stimulus edge as predicted by the edge account. Second, we evaluated whether voxels that contribute most to classifier performance have receptive fields that cluster in cortical regions corresponding to the retinotopic location of the stimulus edge. Instead, we find the distribution of highly weighted voxels to be approximately random, with a modest bias toward more foveal voxels. Our results demonstrate that edge-related activity is likely not necessary for orientation decoding.SIGNIFICANCE STATEMENTA significant theoretical limitation of multivariate pattern analysis in neuroscience is the ambiguity in interpreting the source of decodable information used by classifiers. For example, orientation can be decoded from BOLD activation patterns in human V1, even though orientation columns are at a finer spatial scale than 3T fMRI. Consequently, the source of decodable information remains controversial. Here we test the proposal that information related to the stimulus edges underlies orientation decoding. We map voxel population receptive fields in V1 and evaluate orientation decoding performance as a function of stimulus location in retinotopic cortex. We find orientation is decodable from voxels whose receptive fields do not overlap with the stimulus edges, suggesting edge-related activity does not substantially drive orientation decoding.
Olfactory Bulb Deep Short-Axon Cells Mediate Widespread Inhibition of Tufted Cell Apical Dendrites
Authors: Burton Shawn D. , LaRocca Greg , Liu Annie , Cheetham Claire E.J. , Urban Nathaniel N. 
Published: December 2016

In the main olfactory bulb (MOB), the first station of sensory processing in the olfactory system, GABAergic interneuron signaling shapes principal neuron activity to regulate olfaction. However, a lack of known selective markers for MOB interneurons has strongly impeded cell-type-selective investigation of interneuron function. Here, we identify the first selective marker of glomerular layer-projecting deep short-axon cells (GL-dSACs) and investigate systematically the structure, abundance, intrinsic physiology, feedforward sensory input, neuromodulation, synaptic output, and functional role of GL-dSACs in the mouse MOB circuit. GL-dSACs are located in the internal plexiform layer, where they integrate centrifugal cholinergic input with highly convergent feedforward sensory input. GL-dSAC axons arborize extensively across the glomerular layer to provide highly divergent yet selective output onto interneurons and principal tufted cells. GL-dSACs are thus capable of shifting the balance of principal tufted versus mitral cell activity across large expanses of the MOB in response to diverse sensory and top-down neuromodulatory input.SIGNIFICANCE STATEMENTThe identification of cell-type-selective molecular markers has fostered tremendous insight into how distinct interneurons shape sensory processing and behavior. In the main olfactory bulb (MOB), inhibitory circuits regulate the activity of principal cells precisely to drive olfactory-guided behavior. However, selective markers for MOB interneurons remain largely unknown, limiting mechanistic understanding of olfaction. Here, we identify the first selective marker of a novel population of deep short-axon cell interneurons with superficial axonal projections to the sensory input layer of the MOB. Using this marker, together with immunohistochemistry, acute slice electrophysiology, and optogenetic circuit mapping, we reveal that this novel interneuron population integrates centrifugal cholinergic input with broadly tuned feedforward sensory input to modulate principal cell activity selectively.
Deficient melanocortin-4 receptor causes abnormal reproductive neuroendocrine profile in female mice
Authors: Chen Xiaolin , Huang Lili , Tan Hwee Y , Li Hongzhuo , Wan Ying , Cowley Michael , Veldhuis Johannes D , Chen Chen 
Published: December 2016

Deletion of the melanocortin-4-receptor (Mc4r) gene in mice causes hyperphagia, followed by hyperinsulinemia, obesity and progressive infertility. Evidence shows that the number of developed corpora lutea is reduced in obese MC4R-knockout (MC4R KO) female mice, but the mechanism is unclear. The effect of hyperphagia and obesity by MC4R KO on pulsatile luteinizing hormone (LH) secretion and ovulation remains unknown. In MC4R KO mice and wild-type littermates (WT LM) during the diestrus period throughout different ages, we examined and monitored their metabolic status, pulsatile LH profiles, follicular morphology and the number of corpora lutea. MC4R KO mice were hyperphagic, obese, hyperglycemic, hyperinsulinemic and demonstrated insulin resistance and hepatic steatosis. Irregular estrous cycles and significant changes in the LH secretion profiles were observed in sexually matured 16- to 28-week MC4R KO mice, without any difference in testosterone levels. In addition, MC4R KO mice at 16 weeks of age had significantly fewer corpora lutea than same age WT LM mice. The ovary examinations of MC4R KO mice at 28 weeks of age showed predominantly antral and preovulatory follicles with no corpora lutea. These findings were consistent with the decrease in total, pulsatile, mass and basal LH releases in MC4R KO mice. The characteristics of hormone profiles in obese MC4R KO mice indicate that MC4R plays an important role in regulating LH release, ovulation and reproductive ability probably via hyperphagia-induced obesity. Further study of correlation between metabolic and reproductive regulatory hormones is warranted to dissect the pathological mechanism underlying obesity-induced infertility.Free Chinese abstract: A Chinese translation of this abstract is freely available athttp://www.reproduction-online.org/content/153/3/267/suppl/DC1.
Acerca del Nacimiento de la clínica de Michel Foucault. Aportes teóricos, desafíos filosóficos y vigencia de un texto hecho con los desechos de otro
Authors: López Cristina 
Published: December 2016

El Nacimiento de la Clínica ha sido uno de los textos menos comentados de Michel Foucault. En efecto, publicado entre dos de los trabajos más celebres de su autor, el libro dedicado a trazar la arqueología de la mirada médica fue objeto de una muy escasa recepción. Tal vez por ello podría pasar por un texto menor, de escasa relevancia en su trayectoria, sin repercusiones en el debate filosófico de su tiempo y, visto su enfoque histórico, privado de toda actualidad. Pero, contra este prejuicio, en este artículo, se pondrá en consideración el aporte de esta obra al diseño de la perspectiva arqueológica, los alcances y las limitaciones de la postura filosófica expuesta allí y la vigencia que la reciente discusión biopolítica le ha restituido.
Virtudes y utilidad en David Hume y Jeremy Bentham
Authors: Tasset José L. 
Published: December 2016

En este trabajo me voy a centrar en el análisis de la poco conocida crítica de la teoría de las virtudes de David Hume llevada a cabo por el padre del Utilitarismo clásico, Jeremy Bentham. Este trabajo defiende que la perspectiva humeana en esa teoría, basada en la distinción primordial entre virtudes naturales y artificiales, no sólo es compatible con el utilitarismo clásico, a pesar de las críticas de Jeremy Bentham, sino que puede contribuir a mejorarlo y desarrollarlo por medio de la sólida, compleja y plural visión de la moralidad que propone.
La pequeña edad de hielo en Galicia: estado de la cuestión y estudio histórico
Authors: Fernández Cortizo Camilo 
Published: December 2016

La climatología histórica es una disciplina con escaso desarrollo en Galicia. En particular los estudios sobre la Pequeña Edad de Hielo (PEH) son muy pocos y faltos de continuidad, a diferencia de los estudios dendroclimatológicos y de los geoquímicos y sedimentológicos sobre el paleoclima gallego del Holoceno final, en progresión en las tres últimas décadas. Su utilidad, mayor o menor según los casos, para los historiadores justifica su inclusión en el estado de la cuestión junto con los estudios históricos. A su lista se suma precisamente el presente trabajo, que analiza, utilizando diferentes fuentes documentales (ceremonias de rogativas, diezmos, precios del mercado urbano, libros de difuntos y actas de consistorio), el clima y el tiempo en el Mínimum Maunder tardío (1675-1715), caracterizado en Galicia también por temperaturas más frías que las actuales, por una causada variabilidad climática y, finalmente, por un elevado predominio de las rogativas “pro serenitate temporis”.