bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of midregional pro-adrenomedullin (MR-proADM) at ICU admission and fluid overload in patients post elective cardiac surgery
Authors: Pfortmueller Carmen A. , Ott Isabelle , Müller Martin , Wilson Darius , Schefold Joerg C. , Messmer Anna S. 
Published: September 2024

AbstractPostoperative fluid overload (FO) after cardiac surgery is common and affects recovery. Predicting FO could help optimize fluid management. This post-hoc analysis of the HERACLES randomized controlled trial evaluated the predictive value of MR-proADM for FO post-cardiac surgery. MR-proADM levels were measured at four different timepoints in 33 patients undergoing elective cardiac surgery. Patients were divided into FO (> 5% weight gain) and no-FO at ICU discharge. The primary outcome was the predictive power of MR-proADM at ICU admission for FO at discharge. Secondary outcomes included the predictive value of MR-proADM for FO on day 6 post-surgery and changes over time. The association between MR-proADM and FO at ICU discharge or day 6 post-surgery was not significant (crude odds ratio (cOR): 4.3 (95% CI 0.5–40.9, p = 0.201) and cOR 1.1 (95% CI 0.04–28.3, p = 0.954)). MR-proADM levels over time did not differ significantly between patients with and without FO at ICU discharge (p = 0.803). MR-proADM at ICU admission was not associated with fluid overload at ICU discharge in patients undergoing elective cardiac surgery. MR-proADM levels over time were not significantly different between groups, although elevated levels were observed in patients with FO.
The Yangtze River Delta experienced strong seasonality and regular summer upwelling during the warm mid-Holocene
Authors: Alberti Matthias , Veiga Sandro F. , Chen Bo , Hu Liang , Fang Zheng , Zhou Baochun , Pan Yanhong 
Published: September 2024

AbstractThe mid-Holocene climate optimum saw warm temperatures in large parts of China, but its impact on seasonal environmental changes is not fully understood yet. Here, we use high-resolution geochemical analyses of 7000 to 6000 year-old oyster shells from the Yangtze River Delta to reconstruct climatic and oceanographic patterns. The stable isotope (δ18O, δ13C) and clumped isotope data reflect prominent seasonal changes in temperature, precipitation, and river discharge. Summer months experienced warm temperatures and a distinct increase in rainfalls and river discharge. In contrast, winter months were characterized by a dry season, which might have been longer than today. Stable isotope data also indicate regular summer upwelling in the study area. These results partly disagree with available climate models raising doubts on the models’ reliability. Thus, our palaeo-proxy data offers the possibility to evaluate and correct climate models and thereby improve predictions for the future considering on-going global warming.
Target localization and defect detection of distribution insulators based on ECA‐SqueezeNet and CVAE‐GAN
Authors: Zhang Chao , Liu Yu , Liu Honggang 
Published: September 2024

AbstractInsulators, as typical equipment for distribution networks, provide good electrical insulation between live conductors and earth. Timely and accurate detection is essential for insulator detection issues. However, as the complexity of neural networks increases, the detection efficiency is often lower. Therefore, this paper proposes a fast insulator positioning and defect detection method. Firstly, for insulator target localization, the SqueezeNet network is improved using ECA attention mechanism. In addition, to address the issue of low defect detection accuracy, a joint algorithm has been proposed. The integration of convolutional variational autoencoder (CVAE) and generative adversarial network (GAN) solve their own shortcomings due to different image focus angles. The target localization accuracy reaches 94.30%, and the defect detection accuracy reaches 89.60%. It solves the problems of difficulty in locating small targets in a large field of view and inaccurate detection due to a small number of abnormal samples. This method has been tried and tested in practical distribution network systems.
The mean solar butterfly diagram and poloidal field generation rate at the surface of the Sun
Authors: Cloutier S. , Cameron R. H. , Gizon L. 
Published: September 2024

Context. The difference between individual solar cycles in the magnetic butterfly diagram can mostly be ascribed to the stochasticity of the emergence process.
Aims. We aim to obtain the expectation value of the butterfly diagram from observations of four cycles. This allows us to further determine the generation rate of the surface radial magnetic field.
Methods. We used data from Wilcox Solar Observatory to generate time-latitude diagrams of the surface radial and toroidal magnetic fields spanning cycles 21–24. We symmetrized them across the equator and cycle-averaged them. From the mean butterfly diagram and surface toroidal field, we then inferred the mean poloidal field generation rate at the surface of the Sun.
Results. The averaging procedure removes realization noise from individual cycles. The amount of emerging flux required to account for the evolution of the surface radial field is found to match that provided by the observed surface toroidal field and Joy’s law.
Conclusions. Cycle-averaging butterfly diagrams removes realization noise and artefacts due to imperfect scale separation and corresponds to an ensemble average that can be interpreted in the mean-field framework. The result can then be directly compared to αΩ-type dynamo models. The Babcock-Leighton α-effect is consistent with observations, a result that can be appreciated only if the observational data are averaged in some way.
So-called essential but treated as disposable: Northern California farmworkers working under COVID-19
Authors: Deeb-Sossa Natalia , Torreiro-Casal Mónica , Medel-Herrero Alvaro 
Published: September 2024

AbstractThe workplace emerged as a primary site of infectious disease during the COVID-19 pandemic, especially in occupations having little to no social distancing or potential for remote work. The pandemic had a huge impact on the physical and mental health of farmworkers, and it exposed the labor-market inequities in the United States, exacerbated by the lack of preventive measures to protect these vulnerable workers. In this paper, we use a social constructionist perspective to explore the meaning of “essential worker” by interviewing thirty farmworkers who during the pandemic came to work in a labor market shaped by exploitation and oppression and related unsafe working conditions. We argue that these workers, who are considered “essential” but treated as disposable, work under structural racist capitalism, and our findings contribute to a better understanding of how these Northern California farmworkers perceive being essential under these working conditions.
Global analysis of social learning’s archetypes in natural resource management: understanding pathways of co-creation of knowledge
Authors: Bonatti Michelle , Lana Marcos , Medina Leonardo , Chevelev Paul , Baldivieso Carla , Erismann Carla , Gleich Pia , Rodriguez Tatiana , Eufemia Luca , da Silva Rosa Teresa , Borba Juliano , Matavel Custodio , Schlindwein Sandro , Ison Ray , Eisenack Klaus , Hellin Jon , Pacillo Grazia , Vadez Vincent , Bossuet Jérôme , Dolinska Aleksandra , Sieber Stefan 
Published: September 2024

AbstractAlthough social learning (SL) conceptualization and implementation are flourishing in sustainability sciences, and its non-rigid conceptual fluidity is regarded as an advantage, research must advance the understanding of SL phenomenon patterns based on empirical data, thus contributing to the identification of its forms and triggering mechanisms, particularly those that can address urgent Anthropocene socio-ecological problems. This study aims to discover fundamental patterns along which SL in natural resources management differs by identifying SL archetypes and establishing correlations between the SL process and overall geopolitical conditions. Using a systematic literature review comprising 137 case studies in the five continents, content analysis, and correlations were performed. Results show two main archetypes of social learning (endogenous and exogenous). Their occurrence was linked, to where social learning occurs and how venues/preconditions for social learning are placed. In the Global South, endogenous SL should be better potentialized as a catalyzer of deliberative processes for sustainable natural resources management.
Where would young people using an online STI testing service want to be treated? A survey of young Australians
Authors: Walsh Olivia , Cardwell Ethan T. , Hocking Jane S. , Kong Fabian Y. S. , Ludwick Teralynn 
Published: September 2024

Background Although there has been growth in online STI testing services, more attention is needed to understand how to facilitate effective treatment pathways for users. This study investigated where young people want to be treated for gonorrhoea and syphilis if they test positive using an online service. Methods We conducted an online survey of Australians aged 16–29 years that included multiple choice and free-text questions about their preferred location for receiving injectable antibiotics. Multivariable multinomial logistic regression examined associations between respondent characteristics and service preferences. Content analysis was used to code free-text responses. Results Among 905 survey respondents, 777 (85.9%) answered questions on treatment preferences. Respondents most commonly preferred injectable antibiotics provided by a sexual health clinic (294; 37.8%) or a nurse in a pharmacy (208; 26.8%). Gender/sexually diverse respondents were more likely to select sexual health clinics over general practice (MSM RRR 2.5, 95% CI 1.1–5.7; WSW RRR 2.6, 95% CI 1.1–5.7; trans/non-binary RRR 2.5; 95% CI 1.0–6.0). Older respondents (aged 25–29 years) were more likely to choose all alternatives over general practice, with the reverse found for those who had previously tested. From open-text answers, pharmacies were valued for their convenience, and sexual health clinics for providing non-judgemental, free services by specialists. Conclusions Differences in treatment preferences by certain groups of young people suggest that different service offerings may influence treatment-seeking outcomes from online STI testing services
Flow cytometric immunophenotypic features of acute myeloid leukemia with mast cell differentiation
Authors: Xu Jie , Kim Do Hwan , Wang Wei , Li Shaoying , Lin Pei , Tang Guilin , Konoplev Sergej , Qiu Lianqun , Fang Hong , Garces Sofia , Leventaki Vasiliki , E Shuyu , Medeiros L Jeffrey , Wang Sa A 
Published: September 2024

Abstract

Objectives
Acute myeloid leukemia (AML) with mast cell (MC) differentiation was recently described as an aggressive subgroup of AML cases. The objectives of this study were to assess the flow cytometric immunophenotypic features of AML-MC cases.

Methods
We characterized the immunophenotypic features of 21 AML-MC cases by flow cytometry and compared them to 20 reactive/regenerating bone marrow specimens.

Results
The number of MCs detected by flow cytometry in AML-MC cases ranged from 0.4% to 21.1%, with a median of 3.5%, significantly higher than that of normal/reactive bone marrow (BM) (median, 0.01%; range, 0.000%-0.396%; P &lt; .0001). Immunophenotypically, MCs in AML-MC cases demonstrated immaturity, differing from MCs in normal/reactive BMs, including dimmer CD45 (100% vs 0%), lower side scatter (100% vs 0%), more frequent CD34 (81% vs 20%), and CD123 (100% vs 10%) positivity, and more frequent uniform/increased CD38 expression (95% vs 20%) (all P ≤ .0001). CD2 (0/5) and CD25 (2/6, 1 uniform and 1 partial) were assessed in a subset of cases. The myeloblasts in AML-MC were typically CD34+CD117+HLA-DR+ with unusually frequent expression of CD56 (57%, all partial) and CD25 (63%, mostly partial), increased CD117 (62%), and decreased CD38 (86%). The MC percentage determined by flow cytometry correlated well with MCs detected by tryptase immunohistochemistry (r = 0.76, P &lt; .001).

Conclusions
The MCs in AML-MC cases are characterized by dim CD45, low side scatter, CD34 and CD123 positivity, and uniform and increased CD38 expression. Flow cytometry is an excellent tool for identifying AML-MC cases.
Toxin inhibition: Examining tetracyclines, clindamycin, and linezolid
Authors: Green Sarah B , Albrecht Benjamin , Chapin Ryan , Walters Jillian 
Published: September 2024

Abstract

Purpose
The purpose of this review is to discuss the role of toxin inhibition in select infections and to provide recommendations for appropriate antimicrobial selection when toxin inhibition is indicated.

Summary
For select organisms, specifically Clostridioides difficile, Staphylococcus aureus, and Streptococcus pyogenes, toxin production plays an integral role in overall disease pathogenesis and progression. Some expert recommendations include utilization of an antimicrobial with toxin inhibition properties as primary or adjunctive therapy for certain infections due to these organisms, but evolving data have made the choice of antitoxin agent less clear. Clindamycin has been the long-standing standard of care agent for toxin inhibition in necrotizing S. aureus and S. pyogenes infections, but linezolid shows promise as an alternative either in the setting of drug shortages or simply when clindamycin is not optimal, while tetracyclines require further study for this indication. The role for adjunctive toxin inhibition in C. difficile infection (CDI) is less defined, as current first-line therapies already have antitoxin properties.

Conclusion
Toxin inhibition plays a key role in successful management of patients with infections due to toxin-producing organisms. Adjunctive therapy with a tetracycline could be considered in severe, fulminant CDI, but the associated benefit is variable. The benefit of antitoxin treatment for necrotizing S. aureus and S. pyogenes has been more consistently documented. Recent studies support linezolid as an alternative to clindamycin as an adjunctive S. aureus treatment or as monotherapy when appropriate.
Arbitration and the right to a fair trial
Authors: Tamblyn Nathan 
Published: September 2024

Abstract
It is a good thing to resolve disputes. Yet arbitration is perceived as being contrary to the right to a fair trial under article 6 of the European Convention on Human Rights. Indeed, the current approach of the courts is to say that an agreement to arbitrate is a waiver of the right to a fair trial. That is factually incorrect and alarming in principle. This article investigates the problem and proposes a new approach. The end result confirms the legitimacy of arbitration and improves our understanding around the independence of arbitrators and the confidentiality of proceedings.
How Mild Is the Mild Long COVID? A Comprehensive Neuropsychological Assessment of Patients with Cognitive Complaints
Authors: Lopes-Santos Lucas Emmanuel , de Lacerda Ferreira Diego , de Angelis Geisa , Foss Maria Paula , Trevisan Ana Carolina , de Lacerda Kleython José Coriolano Cavalcanti , Tumas Vitor , Bellissimo-Rodrigues Fernando , Wichert-Ana Lauro 
Published: September 2024

Abstract
The global impact of the Coronavirus Disease (COVID-19) pandemic has extended beyond physical health, leading to widespread mental health issues. Beyond respiratory symptoms, there is a growing concern about long-term cognitive effects, particularly in individuals who experienced mild cases of the infection. We aimed to investigate the neuropsychological aspects of long-term COVID-19 in non-hospitalized adults compared with a control group. This cross-sectional study included 42 participants, 22 individuals with a history of mild COVID, and 20 healthy controls. The participants were recruited from the community and underwent a comprehensive neuropsychological assessment. Participants from the mild COVID group reported cognitive symptoms persisting for an average of 203.86 days and presented a higher frequency of psychological treatment history (81.8%) compared with the control group (25.0%). History of anxiety disorders was more prevalent in the mild COVID group (63.6%) than in the control group (20.0%). Significant reductions in verbal working memory were observed in the mild COVID group. Levels of anxiety were found to have a significant impact on difficulties with visual recognition memory. This study reveals important neuropsychological alterations in individuals following mild COVID-19, emphasizing executive functions deficits. Our findings underscore the persistence of these deficits even in non-hospitalized cases, suggesting potential inflammatory mechanisms in the central nervous system. The study highlights the need for comprehensive assessments and targeted interventions to address the diverse cognitive impacts on individuals recovering from COVID-19.
A Systematic Review to Explore a Neuropsychological Profile that Predates Anorexia Nervosa
Authors: Noon Rachel , Pathan Tayeem 
Published: September 2024

Abstract

Objective
Research demonstrates reduced cognitive flexibility and weak central coherence during acute illness and following recovery from anorexia nervosa (AN). This systematic review investigated if these impairments are present in first-degree relatives of individuals with AN, representing a possible neuropsychological risk profile.

Methods
A systematic review of electronic databases was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search ended on July 14, 2023. Established search terms and inclusion criteria identified relevant research. Risk of bias was assessed using the Critical Appraisal Skills Program. The review was registered with Prospero international prospective register of systematic reviews (No. CRD42023401268). Study selection, descriptive data, critical appraisal, and risk of bias are presented in tables and figures.

Results
The search yielded 10 studies. The included studies conducted neuropsychological assessments of discordant AN relatives and lifetime longitudinal study participants. Most studies found cognitive flexibility and central coherence to be significantly reduced in participants with AN and their relatives compared with controls. One study found decision making to be significantly impaired in AN participants and relatives. Effect sizes were moderate to large.

Discussion
Reduced cognitive flexibility and weak central coherence appear to be endophenotypes of AN. Further research is required with relatives concordant for AN to establish whether these biomarkers co-segregate with AN within families. These findings suggest a possibility of developing screeners to identify individuals at risk of AN allowing for early intervention.
Case Series: Therapeutic Combination of VoluDerm Radiofrequency Microneedling and Glycolic Acid Peel in Scaled-Up Concentrations
Authors: Levenberg Alex , Vinshtok Yuri , Gershonowitz Amikam 
Published: September 2024

Abstract

Background
Glycolic acid (GA) is an α-hydroxy peeling agent that causes controlled removal of the epidermis, with or without the dermis. Studies have shown the ability of GA to stimulate fibroblast proliferation, induce collagen synthesis, and decrease collagen degradation. The VoluDerm radiofrequency microneedling (RFMN; Pollogen, Tel Aviv, Israel) utilizes an array of microelectrodes to penetrate the epidermis and deliver energy to the skin. The controlled fractional thermal injury promotes neocollagenesis in the correction of skin laxity and wrinkle reduction. It was theorized that GA and VoluDerm could synergistically boost collagen production in combined treatment.

Objectives
Safety and efficacy of the combination treatment were investigated in patients seeking corrections of the age-related skin deteriorations.

Methods
Seven female patients (aged 42-70 years, Fitzpatrick II-IV) with photo- and chrono-damaged skin received 5 treatments of VoluDerm followed by the GA peel at increasing 30% to 70% concentrations.

Results
Clinical photography taken 6 months after the treatment demonstrated improvement in elasticity, wrinkling, roughness, pigmentation, erythema, and pore size across the entire treated group. Efficacy quantified by the physician and patients per 1 to 5 Global Aesthetic Improvement Scale was average 4.3 and 4.5, respectively. The treatments were tolerated well without preprocedural anesthesia. Skin phenomena observed after GA application were suggestive of the acid passing to deeper layers.

Conclusions
A novel combination of VoluDerm RFMN and GA at increased concentrations provided safe and effective synergy in the treatment of aging facial skin. Visible results demonstrated skin tightening, reduction of rhytidids, and improvement of the skin texture which may be a result of the combination.

Level of Evidence: 4
‘We kept having this internal conflict around the language of handout and hand-up’: independent living philosophy and rural disability services during the COVID-19 pandemic
Authors: Sage Rayna , Standley Krys , Greiman Lillie , Mashinchi Genna M , Willard Mary 
Published: September 2024

Abstract
In the United States, Centers for Independent Living (CILs) staff were at the frontlines of responding to the impact of the COVID-19 pandemic on rural people with disabilities. Growing out of the Independent Living (IL) Movement , CILs emphasize independence, autonomy, choice, and control for disabled people and do not typically have financial or other resources to give away. To better understand the experiences of CIL staff in using the CARES Act monies and serving rural people with disabilities, researchers at the Rural Institute for Inclusive Communities in collaboration with the Association for Programs in Rural Independent Living (APRIL) used thematic coding to analyze the transcripts of eight national online peer support meetings that were facilitated by APRIL. We found CIL staff described distributing financial assistance to cover essential household needs such as rent, utilities, internet access, and various items. In turn, they also shared that they grappled with conflicts created by the influx of CARES Act funding, which put CIL staff in the position of providing what some described as ‘handouts’ rather than CILs’ usual work of providing consumers with a ‘hand-up’ through training and other non-financial supports. This project highlights a unique challenge CIL staff faced as they attempted to stay true to IL philosophy while concurrently meeting the needs of rural people with disabilities in crisis during the pandemic.