bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Ontamalimab in Treating Inflammatory Bowel Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Awad Abdelaziz A. , Aboelkhier Menna M. , Mohamed Rashad G. , Abbas Ahmed W. , Hageen Ahmed W. , Alnomani Yousef R. , Abouzid Mohamed 
Published: September 2024

Abstract
Purpose of Review
Ontamalimab is an anti-MAdCAM-1 monoclonal antibody. It directly restricts the binding of α4β7 + lymphocytes and does not affect the homing of lymphocytes in the central nervous system. Thus, it diminishes adverse effects while blocking their migration into the gut. Several clinical trials have validated the efficacy and safety of ontamalimab for Crohn's disease and ulcerative colitis. However, to date, there is no meta-analysis on the topic. Hence, we are conducting this meta-analysis. Using R version R.3.3, we reported outcomes as risk ratios (RRs) or mean difference (MD) and confidence intervals (CIs). A P-value ≤ 0.05 is considered as statistically significant.

Recent Findings
The meta-analysis included a total of three studies with 1384 patients. In patients with ulcerative colitis, compared to placebo, ontamalimab had significantly improved clinical remission (RR = 2.17, 95% CI [1.42 to 3.32], P < 0.01), clinical response (RR = 1.79, 95% CI [1.35 to 2.38], P < 0.01), endoscopic response (RR = 2.27, 95% CI [1.55 to 3.31], P < 0.01) and mucosal healing (RR = 2.39, 95% CI [1.63 to 3.50], P < 0.01). No significant differences favoring ontamalimab or the placebo were found regarding safety outcomes. In patients with Crohn's disease, ontamalimab showed superiority over placebo in endoscopic response (RR = 2.00, 95% CI [1.08 to 3.70], P = 0.03). However, ontamalimab was associated with a higher incidence of serious adverse events, and study discontinuations were due to adverse events.

Summary
Ontamalimab has shown promising results, particularly in patients with moderate to severe ulcerative colitis, as evidenced by better clinical response and remission. However, questions remain about its long-term effectiveness and safety; hence, extended follow-up and more extensive studies are necessary.
Innovative and cost-effective rail track construction using recycled rubber
Authors: Indraratna Buddhima , Qi Yujie , Ngo Trung , Malisetty Rakesh , Arachchige Chathuri Kulappu 
Published: September 2024

AbstractFacing the high demand for faster and heavier freight trains in Australia, researchers and practitioners are endeavouring to develop more innovative and resilient ballasted tracks. In recent years, many studies have been conducted by the researchers from Transport Research Centre at the University of Technology Sydney (TRC-UTS) to examine the feasibility of incorporating recycled tyre/rubber into rail tracks. This paper reviews three innovative applications using recycled rubber products such as (1) a synthetic energy-absorbing layer for railway subballast using a composite of rubber crumbs and mining by-products, (2) using rubber intermixed ballast stratum to replace conventional ballast, and (3) installing recycled rubber mat to mitigate ballast degradation under the impact loading. Comprehensive laboratory and field tests as well as numerical modelling have been conducted to examine the performance of rail tracks incorporating these innovative inclusions. The laboratory and field test results and numerical modelling reveal that incorporating these rubber products could increase the energy-absorbing capacity of the track, and mitigate the ballast breakage and settlement significantly, hence increasing the track stability. The research outcomes will facilitate a better understanding of the performance of ballast tracks incorporating these resilient waste tyre materials while promoting more economical and environmentally sustainable tracks for greater passenger comfort and increased safety.
Eudemonia of a machine
Authors: Navon Mois 
Published: September 2024

AbstractHenry Ford once said, “For most purposes, a man with a machine is better than a man without a machine.” To this, engineers today propose an addendum – “and a man thatisa machine is best of all” – which they have made their goal. The world over, engineers are working to make the ultimate machine, “the holy grail of artificial intelligence,” aconscioushumanoid. On the one hand, such a “machine” will be capable of relieving us of all our burdens. On the other hand, in so doing, will we not have “birthed,” as it were, a new class of slaves? In this essay I seek to summarize the various arguments made in this debate, bring to bear moral positions from the philosophy of technology, philosophy of law and philosophy of religion, as well as demonstrate the moral impropriety of such an endeavor from each of the classic moral approaches (i.e., Virtue Ethics, Consequentialism, Kantian Deontology). Finally, given that the debate centers around what is the “good life” for human or humanoid, I expand upon Aristotle’s Eudemonia and Maimonides’Summum Bonumto argue that life is precious in its affordance to allow conscious beings, human or humanoid, to aspire to the best life possible.
Comparison of complication types in patients receiving vesicant intravenous antimicrobials or vasopressors via midlines and peripherally inserted central catheters
Authors: Grigg Bryan , Varghese Nishant , Knapp Christi , Shay Sabra L. , Jones Geraldine , Herlihy James P. , Manian Prasad , Lembcke Bradley , Al Mohajer Mayar 
Published: September 2024

Abstract
We assessed adverse events in hospitalized patients receiving selected vesicant antibiotics or vasopressors administered through midline catheters or peripherally inserted central catheters (PICC). The rates of catheter-related bloodstream infections, thrombosis, and overall events were similar across the two groups, while occlusion was higher in the PICC group.
How can the reworking of Cicero's Pro Cluentio create an appreciation for his literature? Action research exploring methods to support first year A Level students encountering original Latin
Authors: Mistry Dayna 
Published: September 2024

AbstractFrom my experience as a student of Latin, I have always perceived the transition from studying GCSE (sat at ages 14–16) to A Level Latin (sat at ages 17–18) as challenging. As a student, I used the inductive Cambridge Latin Course textbooks, which, as a reading comprehension course, fostered an intuitive sense of grammar. This was appropriate preparation for the GCSE exam. For the A Level exam however, which features greater quantities of difficult original literature and requires explicitly identifying grammatical forms, I had to undertake a lot of independent study, in addition to bridging work. Original Latin was a definite challenge for my peers and me: unusual vocabulary, creative generic form and lapses in grammatical convention were exciting but unfamiliar. With this in mind, I sought to investigate the experience of current Year 12 students.
Unraveling the Impacts: How Extreme Weather Events Disrupt Wood Product Markets
Authors: Johnston Craig M. T. , Henderson Jesse D. , Guo Jinggang , Prestemon Jeffrey P. , Costanza Jennifer 
Published: September 2024

AbstractWhile extreme weather events are often localized, the potential effects on global forests can be far reaching due to the interconnected nature of forest product markets. To better understand these dynamics, this study leverages historical forest‐based wind damage data in the United States and applies this information as shocks within a global forest sector outlook model. A large, localized wind event modeled as a shock to the US South creates a one‐time increase of 18.7 million m3 from salvage harvest operations, equal to over 4% of national harvest. This crowds out traditional harvest activities, leading to downward pressure on prices in the short run, followed by a persistent effect that could take approximately 25 years to dissipate from markets. Average annual wind damage contributes downward pressure on roundwood prices between 1% and 4% in the United States, and this effect is distributed to other countries. The findings suggest that large, localized shocks reverberate across regions and wood product markets due to their interconnected supply chains and trade patterns, and these impacts have important temporal dynamics. Another key result is that the magnitude of these effects are offset by endogenous market reactions in other markets. In other words, unaffected regions change their harvesting patterns in order to compensate for changes in the availability of fiber, shedding light on the importance of capturing global channels as large shocks materialize in changes in market dynamics internationally. Monte Carlo simulations suggest a wide confidence band on salvage harvest rates and prices.
Associations Between Anthropogenic Factors, Meteorological Factors, and Cause‐Specific Emergency Department Admissions
Authors: Tewari Pranav , Xu Baihui , Pei Ma , Tan Kelvin Bryan , Abisheganaden John , Yim Steve Hung‐Lam , Lee Dickens Borame , Lim Jue Tao 
Published: September 2024

AbstractUnpredictable emergency department (ED) admissions challenge healthcare systems, causing resource allocation inefficiencies. This study analyses associations between air pollutants, meteorological factors, and 2,655,861 cause‐specific ED admissions from 2014 to 2018 across 12 categories. Generalized additive models were used to assess non‐linear associations for each exposure, yielding Incidence Rate Ratios (IRR), while the population attributable fraction (PAF) calculated each exposure's contribution to cause‐specific ED admissions. IRRs revealed increased risks of ED admissions for respiratory infections (IRR: 1.06, 95% CI: 1.01–1.11) and infectious and parasitic diseases (IRR: 1.09, 95% CI: 1.03–1.15) during increased rainfall (13.21–16.97 mm). Wind speeds >12.73 km/hr corresponded to increased risks of ED admissions for respiratory infections (IRR: 1.12, 95% CI: 1.03–1.21) and oral diseases (IRR: 1.58, 95% CI: 1.31–1.91). Higher concentrations of air pollutants were associated with elevated risks of cardiovascular disease (IRR: 1.16, 95% CI: 1.05–1.27 for PM10) and respiratory infection‐related ED admissions (IRR: 2.78, 95% CI: 1.69–4.56 for CO). Wind speeds >12.5 km/hr were predicted to contribute toward 10% of respiratory infection ED admissions, while mean temperatures >28°C corresponded to increases in the PAF up to 5% for genitourinary disorders and digestive diseases. PM10 concentrations >60 μg/m3 were highly attributable toward cardiovascular disease (PAF: 10%), digestive disease (PAF: 15%) and musculoskeletal disease (PAF: 10%) ED admissions. CO concentrations >0.6 ppm were highly attributable to respiratory infections (PAF: 20%) and diabetes mellitus (PAF: 20%) ED admissions. This study underscores protective effects of meteorological variables and deleterious impacts of air pollutant exposures across the ED admission categories considered.
Automated Quality Control Scheme for GPM Satellite Precipitation Products
Authors: Tan Jackson , Huffman George J. , Song Yi 
Published: September 2024

AbstractThe constellation approach underpinning precipitation products such as the Integrated Multi‐satellitE Retrievals for GPM (IMERG) is key to achieving high resolution, but the use of data from multiple sources can unintentionally incorporate instrumental artifacts. Here, we introduce a machine learning–based anomaly detection scheme called SPEEDe, which processes a two‐dimensional precipitation field into a re‐estimated precipitation field that can be compared with the input. Large differences identify IMERG fields with bad orbit data, separating most of the bad cases from the good cases. When modified to process the passive microwave inputs, SPEEDe can pick out orbits with bad data, enabling quality control on these IMERG inputs. SPEEDe works by producing a locally realistic‐looking precipitation field when given unphysical data, which results in a larger‐than‐normal difference between the input and the output. SPEEDe is implemented as an automated quality control for GPM precipitation products.
Elevated Tropospheric Iodine Over the Central Continental United States: Is Iodine a Major Oxidant of Atmospheric Mercury?
Authors: Lee C. F. , Elgiar T. , David L. M. , Wilmot T. Y. , Reza M. , Hirshorn N. , McCubbin I. B. , Shah V. , Lin J. C. , Lyman S. N. , Hallar A. G. , Gratz L. E. , Volkamer R. 
Published: September 2024

AbstractPrevious efforts to measure atmospheric iodine have focused on marine and coastal regions. We report the first ground‐based tropospheric iodine monoxide (IO) radical observations over the central continental United States. Throughout April 2022, IO columns above Storm Peak Laboratory, Colorado (3,220 m.a.s.l.) ranged from 0.7 ± 0.5 to 3.6 ± 0.5 × 1012 (average: 1.9 × 1012 molec cm−2). IO was consistently elevated in air masses transported from over the Pacific Ocean. The observed IO columns were up to three times higher and the range was larger than predicted by a global model, which warrants further investigation into iodine sources, sinks, ozone loss, and particle formation. IO mixing ratios increased with altitude. At the observed levels, iodine may be competitive with bromine as an oxidant of elemental mercury at cold temperatures typical of the free troposphere. Iodine‐induced mercury oxidation is missing in atmospheric models, understudied, and helps explain model underestimation of oxidized mercury measurements.
Widespread and Rapid Activities of Retrogressive Thaw Slumps on the Qinghai‐Tibet Plateau From 2016 to 2022
Authors: Xia Zhuoxuan , Liu Lin , Mu Cuicui , Peng Xiaoqing , Zhao Zhuoyi , Huang Lingcao , Luo Jing , Fan Chengyan 
Published: September 2024

AbstractRetrogressive thaw slumps (RTSs), formed by abrupt degradation of ice‐rich permafrost, are widely distributed on the Qinghai‐Tibet Plateau, causing infrastructure damage and enhancing soil carbon emissions. We compiled annual RTS inventories across the plateau from 2016 to 2022 using a deep‐learning‐aided method to quantify the spatial‐temporal variations. We found that RTS‐affected locations increased from 1,592 to 3,805 in 2016–2022, which increased affected areas by 2.8 times from 1,714 to 6,507 ha. The most active initiation and expansion periods were in 2016–2017 and 2018–2019. RTSs tend to be clustered, showing local heterogeneity among clusters characterized by various responses toward high temperatures and precipitation and tendencies to be on different topography and vegetation types. This research reveals the rapid development, wide distribution and regional heterogeneity of RTS activities, serving as a crucial step toward understanding how RTSs respond to climate change and regional environmental varieties.
Short‐Duration Extreme Rainfall Events in the Central and Eastern United States During the Summer: 2003–2023 Trends and Variability
Authors: Chiappa Jason , Parsons David B. , Furtado Jason C. , Shapiro Alan 
Published: September 2024

AbstractExtreme rainfall events (EREs) caused by convection are a major prediction challenge and can lead to deadly flash flooding. This study investigates EREs from 2003 to 2023 over the central and eastern United States using high‐resolution (4‐km) Stage IV precipitation analyses. EREs were defined where 12‐hr accumulations exceeded the 10‐year average recurrence interval thresholds. Summertime (June–August) EREs exhibited pronounced interannual variability, but with statistically significant increasing trends in annual frequency, particularly among those caused by mesoscale convective systems. Significant relationships were also found between summertime convective EREs over the central United States and enhanced poleward moisture transport, consistent with a westward expansion of the climatological North Atlantic Subtropical High. This relationship may aid in medium‐ and long‐range forecasting. However, the spatial scale of EREs often included localized or narrow bands of extreme accumulations, revealing significant challenges in the accurate representation of EREs in weather and climate models.
Crustal 3‐D S‐Wave Velocity and Azimuthal Anisotropy in the Sanjiang Lateral Collision Zone in the SE Margin of the Tibetan Plateau
Authors: Tian Jianhui , Gao Yuan , Li Ying 
Published: September 2024

AbstractThe eastward extrusion of the Tibetan Plateau materials has caused intricate tectonic deformations and frequent seismic activities in the Sanjiang lateral collision zone (SLCZ). To reveal crust structures and deformation mechanisms, we investigate high‐resolution structural features of crustal depth (≤40 km). A 3‐D S‐wave velocity and azimuthal anisotropy model is constructed by the direct tomography method with Rayleigh phase velocity at periods of 2–40 s from multiple temporary seismic arrays and regional permanent network. In the middle‐to‐lower crust, an obvious low‐velocity zone is confined by the large‐scale fault systems of Jinhe‐Qinghe fault and Chenhai fault (CHF) to the northeast and east, Lancangjiang fault (LCJF) and Red River fault (RRF) to the west, with strong N‐S‐oriented anisotropy, which evident differs from the ENE‐WSW‐oriented weak anisotropy in the high‐velocity zone on the northeastern side. We consider that the weak material may be obstructed by large faults and the high‐velocity zone, resulting in complex crustal deformation and tectonic boundary. The crustal low‐velocity materials beneath the Tengchong volcano (TCV) are probably separated with those from the Tibetan Plateau. The low‐velocity beneath the Chuxiong basin (CXB) may be combinations of partial melts and fluid derived from shear deformation and deep material upwelling. The segmented anisotropy at the NW end of the RRF suggests complex deformation by crustal flow, emphasizing the important influence of faults on anisotropic pattern. The complex anisotropy in the fault intersection of the Lijiang‐Xiaojinhe fault and RRF also highlights the important role of these faults in shaping crustal deformation.
A 3‐D Seismic Tomographic Study of Spreading Structures and Smooth Seafloor Generated by Detachment Faulting—The Ultra‐Slow Spreading Southwest Indian Ridge at 64°30′E
Authors: Robinson Adam H. , Watremez Louise , Leroy Sylvie , Minshull Timothy A. , Cannat Mathilde , Corbalán Ana 
Published: September 2024

AbstractAt ultra‐slow spreading ridges, with full spreading rates less than ∼20 mm/yr, spreading is accommodated both by highly spatially and temporally segmented magmatism, and tectonic extension along large‐scale detachment faults that exhume ultramafic material to the seafloor. In the most magma‐poor regions, detachment faulting alternates in polarity over time, producing a “flip‐flopping” effect of subsequent detachment dips. The resulting seafloor in these regions displays a morphology termed “smooth seafloor” comprising elongate, broad ridges with peridotite/serpentinite lithologies. We conducted tomographic travel‐time inversion of a 3‐D wide‐angle seismic data set acquired over a region of smooth seafloor around 64°30′E along the Southwest Indian Ridge (SISMOSMOOTH; Cruise MD199), to produce a seismic velocity volume through the crustal section and into the uppermost mantle. We observe patterns of velocity anomalies that correspond with variations in the bathymetry arising from the mode of spreading and are interpreted as changes in the degree of alteration with depth resulting from spatial and temporal variations in fluid‐rock interaction, controlled by faulting and tectonic damage processes. The detachment faults do not show simple planar structures at depth but instead mirror the shapes of the bathymetric ridges that they exhume. Magmatic input is overall highly limited, but there is one region on the lower part of an exhumed detachment footwall where a thickness of volcanic material is observed that suggests a component of syn‐tectonic volcanism, which could contribute to detachment abandonment.
Brightening triplet excitons enable high-performance white-light emission in organic small molecules via integrating n–π*/π–π* transitions
Authors: Yang Qing , Yang Xinyi , Wang Yixuan , Fei Yunfan , Li Fang , Zheng Haiyan , Li Kuo , Han Yibo , Hattori Takanori , Zhu Pinwen , Zhao Shuaiqiang , Fang Leiming , Hou Xuyuan , Liu Zhaodong , Yang Bing , Zou Bo 
Published: September 2024

AbstractLuminescent materials that simultaneously embody bright singlet and triplet excitons hold great potential in optoelectronics, signage, and information encryption. However, achieving high-performance white-light emission is severely hampered by their inherent unbalanced contribution of fluorescence and phosphorescence. Herein, we address this challenge by pressure treatment engineering via the hydrogen bonding cooperativity effect to realize the mixture of n–π*/π–π* transitions, where the triplet state emission was boosted from 7% to 40% in isophthalic acid (IPA). A superior white-light emission based on hybrid fluorescence and phosphorescence was harvested in pressure-treated IPA, and the photoluminescence quantum yield was increased to 75% from the initial 19% (blue-light emission). In-situ high-pressure IR spectra, X-ray diffraction, and neutron diffraction reveal continuous strengthening of the hydrogen bonds with the increase of pressure. Furthermore, this enhanced hydrogen bond is retained down to the ambient conditions after pressure treatment, awarding the targeted IPA efficient intersystem crossing for balanced singlet/triplet excitons population and resulting in efficient white-light emission. This work not only proposes a route for brightening triplet states in organic small molecules, but also regulates the ratio of singlet and triplet excitons to construct high-performance white-light emission.
Impact of COVID-19 pandemic on ocular disease: KNHANES 2015–2021
Authors: Kim Hyeon Jung , Ryu Yun Kyoung , Shin Young Joo 
Published: September 2024

AbstractThe aim of this study was to evaluate the impact of COVID-19 on ocular diseases and changes in risk factors before and after the COVID-19 pandemic. This study was conducted using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2015–2021, a national cross-sectional health examination and survey. Associations between ocular diseases and risk factors were determined using the chi-squared test and logistic regression analysis. Bivariable adjusted logistic regression analysis was performed to examine the odds ratio (OR) and 95% confidence interval (CI) to evaluate of the impact of COVID-19 on ocular diseases. Individuals were divided into two age groups (< 60 and ≥ 60 years). A total of 50,158 people were diagnosed, of whom 7270 were diagnosed with cataract, 921 with glaucoma, and 439 with age-related macular degeneration (AMD). Risk factors for cataract were COVID-19 pandemic (OR 1.161), hypertension (OR 1.608), diabetes (OR 1.573), dyslipidemia (OR 1.167), stroke (OR 1.272), and depression (OR 1.567). Risk factors for AMD were COVID-19 pandemic (OR 1.600), dyslipidemia (OR 1.610), and depression (OR 1.466). Risk factors for glaucoma were hypertension (OR 1.234), dyslipidemia (OR 1.529), diabetes (OR 1.323), and depression (OR 1.830). The COVID-19 pandemic was a risk factor for cataracts and AMD, but not for glaucoma. Cataracts and AMD may be more influenced by the acquired health conditions or the environment.