bluuebunny/crossref_metadata_2025_split huggingface dataset:
l-Tyrosine Confers Residualizing Properties to a d-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies
Authors: Lee Fook T. , Burvenich Ingrid J. G. , Guo Nancy , Kocovski Pece , Tochon-Danguy Henri , Ackermann Uwe , O’Keefe Graeme J. , Gong Sylvia , Rigopoulos Angela , Liu Zhanqi , Gan Hui K. , Scott Andrew M. 
Published: July 2016

Purpose: The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies with 124I to support clinical development using immuno-positron emission tomography (PET). Methods: The anti-epidermal growth factor receptor antibody ch806 was radiolabeled directly or indirectly with isotopes and various residualizing peptides. Azido-derivatized radiolabeled peptides were conjugated to dibenzylcyclooctyne-derivatized ch806 antibody via click chemistry. The radiochemical purities, antigen-expressing U87MG.de2-7 human glioblastoma cell-binding properties, and targeting of xenografts at 72 hours post injection of all radioconjugates were compared. Biodistribution of 124I-PEG4-tptddYddtpt-ch806 and immuno-PET imaging were evaluated in tumor-bearing mice. Results: Biodistribution studies using xenografts at 72 hours post injection showed that 131I-PEG4-tptddYddtpt-ch806 tumor uptake was similar to 111In-CHX-A″-DTPA-ch806. 125I-PEG4-tptddyddtpt-ch806 showed a lower tumor uptake value but higher than directly labeled 125I-ch806. 124I-PEG4-tptddYddtpt-ch806 was produced at 23% labeling efficiency, 98% radiochemical purity, 25.9 MBq/mg specific activity, and 64% cell binding in the presence of antigen excess. Tumor uptake for 124I-PEG4-tptddYddtpt-ch806 was similar to 111In-CHX-A″-DTPA-ch806. High-resolution immuno-PET/magnetic resonance imaging of tumors showed good correlation with biodistribution data. Conclusions: The mixed d/l-enantiomeric peptide, dThr-dPro-dThr-dAsp-dAsp-Tyr-dAsp-dAsp-dThr-dPro-dThr, is suitable for radiolabeling antibodies with radiohalogens such as 124I for high-resolution immuno-PET imaging of tumors and for evaluation in early-phase clinical trials.
Mothers screening for malnutrition by mid-upper arm circumference is non-inferior to community health workers: results from a large-scale pragmatic trial in rural Niger
Authors: Alé Franck G.B. , Phelan Kevin P.Q. , Issa Hassan , Defourny Isabelle , Le Duc Guillaume , Harczi Geza , Issaley Kader , Sayadi Sani , Ousmane Nassirou , Yahaya Issoufou , Myatt Mark , Briend André , Allafort-Duverger Thierry , Shepherd Susan , Blackwell Nikki 
Published: July 2016

Abstract

Background
Community health workers (CHWs) are recommended to screen for acute malnutrition in the community by assessing mid-upper arm circumference (MUAC) on children between 6 and 59 months of age. MUAC is a simple screening tool that has been shown to be a better predictor of mortality in acutely malnourished children than other practicable anthropometric indicators. This study compared, under program conditions, mothers and CHWs in screening for severe acute malnutrition (SAM) by color-banded MUAC tapes.

Methods
This pragmatic interventional, non-randomized efficacy study took place in two health zones of Niger’s Mirriah District from May 2013 to April 2014. Mothers in Dogo (Mothers Zone) and CHWs in Takieta (CHWs Zone) were trained to screen for malnutrition by MUAC color-coded class and check for edema. Exhaustive coverage surveys were conducted quarterly, and relevant data collected routinely in the health and nutrition program. An efficacy and cost analysis of each screening strategy was performed.

Results
A total of 12,893 mothers and caretakers were trained in the Mothers Zone and 36 CHWs in the CHWs Zone, and point coverage was similar in both zones at the end of the study (35.14 % Mothers Zone vs 32.35 % CHWs Zone, p = 0.9484). In the Mothers Zone, there was a higher rate of MUAC agreement (75.4 % vs 40.1 %, p <0.0001) and earlier detection of cases, with median MUAC at admission for those enrolled by MUAC <115 mm estimated to be 1.6 mm higher using a smoothed bootstrap procedure. Children in the Mothers Zone were much less likely to require inpatient care, both at admission and during treatment, with the most pronounced difference at admission for those enrolled by MUAC < 115 mm (risk ratio = 0.09 [95 % CI 0.03; 0.25], p < 0.0001). Training mothers required higher up-front costs, but overall costs for the year were much lower ($8,600 USD vs $21,980 USD.)

Conclusions
Mothers were not inferior to CHWs in screening for malnutrition at a substantially lower cost. Children in the Mothers Zone were admitted at an earlier stage of SAM and required fewer hospitalizations. Making mothers the focal point of screening strategies should be included in malnutrition treatment programs.

Trial registration
The trial is registered with clinicaltrials.gov (Trial number NCT01863394).
Streaming algorithms for identification pathogens and antibiotic resistance potential from real-time MinION™ sequencing
Authors: Cao Minh Duc , Ganesamoorthy Devika , Elliott Alysha G , Zhang Huihui , Cooper Matthew A , Coin Lachlan J M 
Published: July 2016

Abstract
The recently introduced Oxford Nanopore MinION platform generates DNA sequence data in real-time. This has great potential to shorten the sample-to-results time and is likely to have benefits such as rapid diagnosis of bacterial infection and identification of drug resistance. However, there are few tools available for streaming analysis of real-time sequencing data. Here, we present a framework for streaming analysis of MinION real-time sequence data, together with probabilistic streaming algorithms for species typing, strain typing and antibiotic resistance profile identification. Using four culture isolate samples, as well as a mixed-species sample, we demonstrate that bacterial species and strain information can be obtained within 30 min of sequencing and using about 500 reads, initial drug-resistance profiles within two hours, and complete resistance profiles within 10 h. While strain identification with multi-locus sequence typing required more than 15x coverage to generate confident assignments, our novel gene-presence typing could detect the presence of a known strain with 0.5x coverage. We also show that our pipeline can process over 100 times more data than the current throughput of the MinION on a desktop computer.
Why so little effort to study anti-oxidant therapy in burns?
Authors: Klein Gordon L. 
Published: July 2016

AbstractGiven that oxidative stress is an inherent response to burn injury, it is puzzling as to why investigation into anti-oxidant therapy as an adjunct to burn treatment has been limited. Both the inflammatory response and the stress response to burn injury involve oxidative stress, and there has been some limited success in studies using gamma tocopherol and selenium to improve certain consequences of burns. Much remains to be done to investigate the number, doses and combinations of anti-oxidants, their efficacy, and limitations in improving defined outcomes after burn injury.
Phase III Randomized Trial of Ipilimumab Plus Etoposide and Platinum Versus Placebo Plus Etoposide and Platinum in Extensive-Stage Small-Cell Lung Cancer
Authors: Reck Martin , Luft Alexander , Szczesna Aleksandra , Havel Libor , Kim Sang-We , Akerley Wallace , Pietanza Maria Catherine , Wu Yi-long , Zielinski Christoph , Thomas Michael , Felip Enriqueta , Gold Kathryn , Horn Leora , Aerts Joachim , Nakagawa Kazuhiko , Lorigan Paul , Pieters Anne , Kong Sanchez Teresa , Fairchild Justin , Spigel David 
Published: July 2016

PurposePatients with extensive-stage disease small-cell lung cancer (SCLC) have poor survival outcomes despite first-line chemotherapy with etoposide and platinum. This randomized, double-blind phase III study evaluated the efficacy and safety of ipilimumab or placebo plus etoposide and platinum in patients with newly diagnosed extensive-stage disease SCLC.Patients and MethodsPatients were randomly assigned at a ratio of one to one to receive chemotherapy with etoposide and platinum (cisplatin or carboplatin) plus ipilimumab 10 mg/kg or placebo every 3 weeks for a total of four doses each in a phased induction schedule (chemotherapy in cycles one to four; ipilimumab or placebo beginning in cycle three up to cycle six), followed by ipilimumab or placebo maintenance every 12 weeks. Primary end point was overall survival (OS) among patients receiving at least one dose of blinded study therapy.ResultsOf 1,132 patients randomly assigned, 954 received at least one dose of study therapy (chemotherapy plus ipilimumab, n = 478; chemotherapy plus placebo, n = 476). Median OS was 11.0 months for chemotherapy plus ipilimumab versus 10.9 months for chemotherapy plus placebo (hazard ratio, 0.94; 95% CI, 0.81 to 1.09; P = .3775). Median progression-free survival was 4.6 months for chemotherapy plus ipilimumab versus 4.4 months for chemotherapy plus placebo (hazard ratio, 0.85; 95% CI, 0.75 to 0.97). Rates and severity of treatment-related adverse events were similar between arms, except for diarrhea, rash, and colitis, which were more frequent with chemotherapy plus ipilimumab. Rate of treatment-related discontinuation was higher with chemotherapy plus ipilimumab (18% v 2% with chemotherapy plus placebo). Five treatment-related deaths occurred with chemotherapy plus ipilimumab and two with chemotherapy plus placebo.ConclusionAddition of ipilimumab to chemotherapy did not prolong OS versus chemotherapy alone in patients with newly diagnosed extensive-stage disease SCLC. No new or unexpected adverse events were observed with chemotherapy plus ipilimumab. Several ongoing studies are evaluating ipilimumab in combination with programmed death-1 inhibitors in SCLC.
Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline
Authors: Paice Judith A. , Portenoy Russell , Lacchetti Christina , Campbell Toby , Cheville Andrea , Citron Marc , Constine Louis S. , Cooper Andrea , Glare Paul , Keefe Frank , Koyyalagunta Lakshmi , Levy Michael , Miaskowski Christine , Otis-Green Shirley , Sloan Paul , Bruera Eduardo 
Published: July 2016

Purpose To provide evidence-based guidance on the optimum management of chronic pain in adult cancer survivors. Methods An ASCO-convened expert panel conducted a systematic literature search of studies investigating chronic pain management in cancer survivors. Outcomes of interest included symptom relief, pain intensity, quality of life, functional outcomes, adverse events, misuse or diversion, and risk assessment or mitigation. Results A total of 63 studies met eligibility criteria and compose the evidentiary basis for the recommendations. Studies tended to be heterogeneous in terms of quality, size, and populations. Primary outcomes also varied across the studies, and in most cases, were not directly comparable because of different outcomes, measurements, and instruments used at different time points. Because of a paucity of high-quality evidence, many recommendations are based on expert consensus. Recommendations Clinicians should screen for pain at each encounter. Recurrent disease, second malignancy, or late-onset treatment effects in any patient who reports new-onset pain should be evaluated, treated, and monitored. Clinicians should determine the need for other health professionals to provide comprehensive pain management care in patients with complex needs. Systemic nonopioid analgesics and adjuvant analgesics may be prescribed to relieve chronic pain and/or to improve function. Clinicians may prescribe a trial of opioids in carefully selected patients with cancer who do not respond to more conservative management and who continue to experience distress or functional impairment. Risks of adverse effects of opioids should be assessed. Clinicians should clearly understand terminology such as tolerance, dependence, abuse, and addiction as it relates to the use of opioids and should incorporate universal precautions to minimize abuse, addiction, and adverse consequences. Additional information is available at www.asco.org/chronic-pain-guideline and www.asco.org/guidelineswiki .
Adipose and Circulating CCL18 Levels Associate With Metabolic Risk Factors in Women
Authors: Eriksson Hogling Daniel , Petrus Paul , Gao Hui , Bäckdahl Jesper , Dahlman Ingrid , Laurencikiene Jurga , Acosta Juan , Ehrlund Anna , Näslund Erik , Kulyte Agne , Mejhert Niklas , Andersson Daniel P. , Arner Peter , Rydén Mikael 
Published: July 2016

Context:
Cardiometabolic complications in obesity may be linked to white adipose tissue (WAT) dysfunction. Transcriptomic studies of Sc WAT have reported that CCL18, encoding the CC chemokine ligand 18 (CCL18), is increased in obesity/insulin resistance but its functional role is unknown.

Objective:
Our objectives were to determine if CCL18 is secreted from Sc WAT and if secreted and/or serum levels associate with metabolic phenotypes. We also planned to define the primary cellular source and if CCL18 exerts effects on adipocytes.

Design:
This is a cohort study.

Setting:
The study took place in an outpatient academic clinic.

Participants:
A total of 130 obese women scheduled for bariatric surgery and 35 nonobese controls were included.

Methods:
Insulin sensitivity was assessed by hyperinsulinemic euglycemic clamp or homeostasis model assessment. CCL18 was analyzed in serum/WAT incubates by ELISA. Effects of recombinant CCL18 was determined in cultures of primary human adipocytes and the monocyte cell line THP-1 differentiated into M0/M1/M2 macrophages.

Main Outcome Measure:
Association with metabolic risk factors was measured.

Results:
CCL18 was secreted from WAT and the levels correlated positively with insulin resistance, Adult Treatment Panel III risk score and plasma triglycerides, independent of body mass index and better than other established adipocytokines. In 80 obese women, S-CCL18 levels were significantly higher in insulin resistant compared with insulin sensitive subjects. In WAT CCL18 mRNA was expressed in macrophages and correlated positively with immune-related genes, particularly those enriched in M2 macrophages. While CCL18 increased cyto-/chemokine expression in M0/M2-THP-1 cells, human adipocytes showed no responses in vitro.

Conclusions:
Circulating and WAT-secreted CCL18 correlates with insulin resistance and metabolic risk score. Because CCL18 is macrophage-specific and associates with adipose immune gene expression, it may constitute a marker of WAT inflammation.
Review Essay
Authors: Fassetta Giovanna , Phipps Alison , Grazia Maria 
Published: July 2016

Abstract
THE GAZE OF THE WEST AND FRAMINGS OF THE EAST, SHANTA NAIR-VENUGOPAL (ED.) (2012) Basingstoke: Palgrave Macmillan, XV + 264 pp. ISBN: 978-0-230-30292-1, h/bk, £66.00
Two Stage Assessment of Thermal Hazard in An Underground Mine
Authors: Drenda Jan , Sułkowski Józef , Pach Grzegorz , Różański Zenon , Wrona Paweł 
Published: July 2016

Abstract
The results of research into the application of selected thermal indices of men’s work and climate indices in a two stage assessment of climatic work conditions in underground mines have been presented in this article. The difference between these two kinds of indices was pointed out during the project entitled “The recruiting requirements for miners working in hot underground mine environments”. The project was coordinated by The Institute of Mining Technologies at Silesian University of Technology. It was a part of a Polish strategic project: “Improvement of safety in mines” being financed by the National Centre of Research and Development.
Climate indices are based only on physical parameters of air and their measurements. Thermal indices include additional factors which are strictly connected with work, e.g. thermal resistance of clothing, kind of work etc.
Special emphasis has been put on the following indices - substitute Silesian temperature (TS) which is considered as the climatic index, and the thermal discomfort index (δ) which belongs to the thermal indices group.
The possibility of the two stage application of these indices has been taken into consideration (preliminary and detailed estimation). Based on the examples it was proved that by the application of thermal hazard (detailed estimation) it is possible to avoid the use of additional technical solutions which would be necessary to reduce thermal hazard in particular work places according to the climate index. The threshold limit value for TS has been set, based on these results. It was shown that below TS = 24°C it is not necessary to perform detailed estimation.
Method for Determining the Coalbed Methane Content with Determination the Uncertainty of Measurements
Authors: Szlązak Nikodem , Korzec Marek 
Published: July 2016

AbstractMethane has a bad influence on safety in underground mines as it is emitted to the air during mining works. Appropriate identification of methane hazard is essential to determining methane hazard prevention methods, ventilation systems and methane drainage systems. Methane hazard is identified while roadways are driven and boreholes are drilled. Coalbed methane content is one of the parameters which is used to assess this threat. This is a requirement according to the Decree of the Minister of Economy dated 28 June 2002 on work safety and hygiene, operation and special firefighting protection in underground mines. For this purpose a new method for determining coalbed methane content in underground coal mines has been developed. This method consists of two stages - collecting samples in a mine and testing the sample in the laboratory. The stage of determining methane content in a coal sample in a laboratory is essential. This article presents the estimation of measurement uncertainty of determining methane content in a coal sample according to this methodology.
Community-based tourism in practice: evidence from three coastal communities in Bohuslän, Sweden
Authors: Lindström Kristina N. , Larson Mia 
Published: July 2016

Abstract
Local involvement in tourism development is defined as a key issue for sustainable tourism, however it is often questioned and less seldom implemented in reality. Reasons behind this condition are lack of knowledge and practical experience on community-based tourism as a bottom-up approach. In this paper it is argued that local involvement in tourism development is both a democratic right and a strategic destination management tool. The paper scrutinizes a process of collaboration and local participation in a tourism development project within three coastal communities on the Swedish West Coast. A mixed-methods approach was employed in the project with the specific aim of investigating attitudes to the community and tourism development and of involving community stakeholders in exploring alternative avenues of tourism development. The article describes four phases of the process of local involvement in a tourism development project: step 1, formation of a representative project group and negotiation of community-based approach; step 2, consulting local stakeholders and employing a mixed-methods approach; step 3, elaborating results with local stakeholders; step 4, increased community collaboration.
Urbanization processes related to the development of residential functions in gminas adjacent to the city of Olsztyn
Authors: Szczepańska Agnieszka 
Published: July 2016

Abstract
Political transformations in Poland have led to rapid suburbanization. Suburbias are beginning to develop functions and services characteristic of urban areas. The highest rate of growth is noted in residential development, in particular in the segment of single-family homes. Those developments bring about changes in demographics and social infrastructure. This study analyzes 4,000 real estate transactions conducted in 2007-2014, involving land plots zoned for residential construction, in order to determine the spatial changes that take place in the gminas adjacent to the city of Olsztyn, in view of the development of the local real estate market. The major trends relating to the number of concluded transactions, changes in real estate prices over time, the number of completed construction projects (new single-family homes) and changes in land-use structure are described. Demographic and social changes that inevitably follow from urbanization are described in the analyzed gminas. The results of this study will be used to determine whether Olsztyn’s suburbias are merely “bedroom communities” or whether they constitute autonomous territorial units.
Evaluation of spatial differentiation in the Pilsen region from a socioeconomic perspective
Authors: Novotná Marie , Šlehoferová Marta , Matušková Alena 
Published: July 2016

Abstract
The main objective of this article is to evaluate spatial differentiation in the Pilsen region in the Czech Republic, to create a typology of territorial units, and to evaluate the potential for development and possible threats to development in relation to individual territorial types. To this end, municipal statistical indicators pertaining to population, employment, and economy, were gathered from each of the given territories. The Voronoi map technique was applied to interpolate the values of selected indicators. The typology was created using one of the multivariate statistical methods, namely, the cluster analysis. Furthermore, typological regions and strategies for their development were created.
Spatial structure of a city and the mobility of its residents: functional and planning aspects
Authors: Parysek Jerzy J. , Mierzejewska Lidia 
Published: July 2016

Abstract
In the latest conceptions of urban development planning, special attention is paid to the resident. This is reflected especially in the increasingly popular idea of creating ‘a city for people’. This somewhat banal slogan has got an increasingly sensible and justified theoretical support, as well as examples of practical solutions. The idea of planning urban development to meet human needs (a city for people) underlies many conceptions of urban development, especially those the basic goal of which is to limit suburbanisation unfavourable from a general social point of view and to rationalise the mobility of city residents. It has long been known that their mobility reflects the spatial structure of a city, and that their ever more intensive movement is not favourable from the ecological, social and economic points of view. In this situation it is necessary to shape the spatial-functional structure of the city in a way that will, first, restrict this mobility and, secondly, that will change the ways and means by which residents move. However, in order to make changes in the existing spatial structures in a rational way, it is necessary to know the mobility of city dwellers, its causes, directions, distances covered, and duration. What we shall present in this paper are structural and functional conclusions resulting from an analysis of the mobility of residents relevant for planning. Although our reflections will be primarily theoretical in nature, in many cases they will be backed up by empirical studies, mostly concerning Poznań.
Tourist guides’ perceptions of cultural heritage tourism in South Africa
Authors: Merwe Clinton David van der 
Published: July 2016

Abstract
Heritage tourism is a fast growing niche of cultural tourism worldwide. In Africa, several countries, including South Africa, place great emphasis on the growth of heritage tourism because of its potential for local economic development. Cultural and heritage tourism are being advocated as an important niche within the South African economy. This paper explores the perceptions of cultural heritage tourist guides in South Africa towards heritage tourism, it is argued that the country’s National Department of Tourism must improve the poor governance and poor management of South African heritage assets, and enhance the preservation, transformation and segmented marketing of South Africa’s cultural assets (at all levels of government) in order to sustain and grow cultural tourism in the future.