bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrologic processes that govern stormwater infrastructure behaviour
Authors: Eger Caitlin G. , Chandler David G. , Driscoll Charles T. 
Published: September 2017

AbstractUsing water budget data from published literature, we demonstrate how hydrologic processes govern the function of various stormwater infrastructure technologies. Hydrologic observations are displayed on a Water Budget Triangle, a ternary plot tool developed to visualize simplified water budgets, enabling side‐by‐side comparison of green and grey approaches to stormwater management. The tool indicates ranges of hydrologic function for green roofs, constructed wetlands, cisterns, bioretention, and other stormwater control management structures. Water budgets are plotted for several example systems to provide insight on structural and environmental design factors, and seasonal variation in hydrologic processes of stormwater management systems. Previously published water budgets and models are used to suggest appropriate operational standards for several green and grey stormwater control structures and compare between conventional and low‐impact development approaches. We compare models, characterize and quantify water budgets and expected ranges for green and grey infrastructure systems, and demonstrate how the Water Budget Triangle tool may help users to develop a data‐driven approach for understanding design and retrofit of green stormwater infrastructure.
Risk analysis and technology assessment in support of technology development: Putting responsible innovation in practice in a case study for nanotechnology
Authors: van Wezel Annemarie P , van Lente Harro , van de Sandt Johannes JM , Bouwmeester Hans , Vandeberg Rens LJ , Sips Adrienne JAM 
Published: September 2017

Abstract

Governments invest in “key enabling technologies,” such as nanotechnology, to solve societal challenges and boost the economy. At the same time, governmental agencies demand risk reduction to prohibit any often unknown adverse effects, and industrial parties demand smart approaches to reduce uncertainties. Responsible research and innovation (RRI) is therefore a central theme in policy making. Risk analysis and technology assessment, together referred to as “RATA,” can provide a basis to assess human, environmental, and societal risks of new technological developments during the various stages of technological development. This assessment can help both governmental authorities and innovative industry to move forward in a sustainable manner. Here we describe the developed procedures and products and our experiences to bring RATA in practice within a large Dutch nanotechnology consortium. This is an example of how to put responsible innovation in practice as an integrated part of a research program, how to increase awareness of RATA, and how to help technology developers perform and use RATA. Integr Environ Assess Manag 2018;14:9–16. © 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC)

Key Points
Risk analysis and technology assessment (RATA) help to assess human, environmental, and societal risks during technological development. We describe our experiences to bring RATA in practice in a large Dutch nanotechnology consortium. As an integrated part of innovation, RATA intensifies interaction among innovators, RATA researchers, and regulators. The approach described might also inspire responsible innovation for other emerging technologies and could be coupled to governmental investments in stimulating technology developments.
Transplantation of Noncultured Stromal Vascular Fraction Cells of Adipose Tissue Ameliorates Osteonecrosis of the Jaw–Like Lesions in Mice
Authors: Kuroshima Shinichiro , Sasaki Muneteru , Nakajima Kazunori , Tamaki Saki , Hayano Hiroki , Sawase Takashi 
Published: September 2017

ABSTRACT

The precise pathoetiology and effective treatment strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ) remain unknown. Transplantation of noncultured stromal vascular fraction (SVF) cells has been shown to be a useful method for regenerative medicine in place of stem cell therapy. This study investigated the effects of noncultured SVF transplantation on tooth extraction socket healing in mice. Both chemotherapeutic/bisphosphonate combination therapy for 7 weeks and tooth extraction of maxillary first molars at 3 weeks after drug administration were performed using female C57BL/6J mice. Osseous and soft tissue wound healing were validated at 4 weeks postextraction using gross wound healing and histomorphometry. Here, we created a new animal model of high-prevalence ONJ-like lesions that mimic human progression, because human ONJ mainly occurs in female patients taking both chemotherapeutic and bisphosphonate following tooth extraction. Moreover, mice with chemotherapeutic and bisphosphonate combination therapy for 5 weeks received SVF transplantation just after tooth extraction at 3 weeks post–drug administration. Euthanasia was performed at 2 weeks postextraction to assess the transplantation effects on wound healing using gross wound healing, histomorphometry, immunohistomorphometry, quantitative real-time polymerase chain reaction, and microcomputed tomography. We showed that systemic transplantation of noncultured SVF cells ameliorates ONJ-like lesions by improving both osseous and soft tissue healing of tooth extraction sockets. SVF therapy significantly increased blood vessels and the ratio of M2/M1 macrophages. In addition, SVF transplantation reduced the increases in tartrate-resistant acid phosphatase–positive (TRAP+) mononuclear cells (MNCs) and nonattached osteoclasts from the bone surface, which were significantly detected in the connective tissue of tooth extraction sockets and bone marrow by chemotherapeutic/bisphosphonate combination therapy. Our findings suggest that transplantation of noncultured SVF cells is a suitable treatment for BRONJ. Abnormal TRAP+ MNCs and nonattached osteoclasts in systemic and local environments may contribute to the development of BRONJ. © 2017 American Society for Bone and Mineral Research.
Abstract
(A) Cyclophosphamide (CY) and bisphosphonate (ZA) combination therapy (CY/ZA) induced BRONJ-like lesions with impaired osseous and compromised soft tissue healing of tooth extraction sockets, as compared with VC (saline) administration in C57B6/J mice. (B) Stromal vascular fraction (SVF) cells from inguinal fad pad by enzymatic treatment and centrifugation were transplanted into mice with ONJ-like lesions. (C) Transplantation of SVF cells ameliorate BRONJ-like lesions with promoted osseous wound healing and improved soft tissue healing.
The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study
Authors: Taslimi Parham , Caglayan Cuneyt , Gulcin İlhami 
Published: September 2017

AbstractNatural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), α‐glucosidase (α‐Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). These phenolic compounds were tested for the inhibition of α‐glycosidase, hCA I, hCA II, AChE, and BChE enzymes and demonstrated efficient inhibition profiles with Ki values in the range of 3.70 ± 0.92–79.66 ± 20.81 nM against hCA I, 2.98 ± 0.33–84.88 ± 40.32 nM against hCA II, 4.93 ± 2.01–593.60 ± 134.74 nM against α‐Gly, 0.52 ± 0.18–46.80 ± 17.15 nM against AChE, and 1.25 ± 0.22–32.08 ± 2.68 against BChE.
On the number of minimal separators in graphs
Authors: Gaspers Serge , Mackenzie Simon 
Published: September 2017

AbstractWeconsider the largest number of minimal separators a graph on n vertices can have.

We give a new proof that this number is in .
We prove that this number is in , improving on the previous best lower bound of .This gives also an improved lower bound on the number of potential maximal cliques in a graph. We would like to emphasize that our proofs are short, simple, and elementary.
8000 years of North Atlantic storminess reconstructed from a Scottish peat record: implications for Holocene atmospheric circulation patterns in Western Europe
Authors: Stewart H. , Bradwell T. , Bullard J. , Davies S. J. , Golledge N. , McCulloch R. D. 
Published: September 2017

ABSTRACTNorth Atlantic storminess can affect human settlements, infrastructure and transport links, all of which strongly impact local, national and global economies. An increase in storm frequency and intensity is predicted over the North‐East Atlantic in the 21st century because of a northward shift in storm tracks and a persistently positive North Atlantic Oscillation (NAO), driven by recent atmospheric warming. Although documentary records of North Atlantic storminess exist, these are generally limited to the last c. 1000 years. This paper presents a continuous high‐resolution proxy record of storminess spanning the last 8000 years from a 6 m‐long core taken from a peat bog in northern Scotland. Bromine concentrations in the peat, derived from sea spray, are used to reconstruct storm frequency and storm intensity, and mire surface wetness is used as an indicator of longer‐term climate shifts. The results suggest a relationship between positive phases of the NAO and increased North Atlantic storminess. However, subtle differences between bromine concentrations and mire surface wetness suggest that high‐intensity but perhaps less frequent periods of storminess are not necessarily associated with a wetter climate.
Enhanced Piezoelectric Performance of Electrospun Polyvinylidene Fluoride Doped with Inorganic Salts
Authors: Yu Bin , Mao Mengye , Yu Hao , Huang Tao , Zuo Weiwei , Wang Hongzhi , Zhu Meifang 
Published: September 2017

AbstractA novel approach to preparing electrospun polyvinylidene fluoride (PVDF) nanofibers is proposed, with high piezoelectric performance. PVDF nanofibers are doped with inorganic salts without the use of any postpolarization treatment. Twenty‐six salts are doped into the nanofibers and their piezoelectric properties are studied. The salts are classified into three groups based on their differing piezoelectric enhancement effects. A piezoelectric nanogenerator fabricated with an optimized electrospun PVDF nanofiber mat shows a piezovoltage seven times greater than that of a device based on undoped nanofibers. The simple and low‐cost approach to fabricate these piezoelectric nanofiber mats may broaden the range of industrial applications of these materials in energy‐harvesting devices and portable sensors.
Learning‐based deformable registration for infant MRI by integrating random forest with auto‐context model
Authors: Wei Lifang , Cao Xiaohuan , Wang Zhensong , Gao Yaozong , Hu Shunbo , Wang Li , Wu Guorong , Shen Dinggang 
Published: September 2017

PurposeAccurately analyzing the rapid structural evolution of human brain in the first year of life is a key step in early brain development studies, which requires accurate deformable image registration. However, due to (a) dynamic appearance and (b) large anatomical changes, very few methods in the literature can work well for the registration of two infant brain MR images acquired at two arbitrary development phases, such as birth and one‐year‐old.MethodsTo address these challenging issues, we propose a learning‐based registration method, which can handle the anatomical structures and the appearance changes between the two infant brain MR images with possible time gap. Specifically, in the training stage, we employ a multioutput random forest regression and auto‐context model to learn the evolution of anatomical shape and appearance from a training set of longitudinal infant images. To make the learning procedure more robust, we further harness the multimodal MR imaging information. Then, in the testing stage, for registering the two new infant images scanned at two different development phases, the learned model will be used to predict both the deformation field and appearance changes between the images under registration. After that, it becomes much easier to deploy any conventional image registration method to complete the remaining registration since the above‐mentioned challenges for state‐of‐the‐art registration methods have been well addressed.ResultsWe have applied our proposed registration method to intersubject registration of infant brain MR images acquired at 2‐week‐old, 3‐month‐old, 6‐month‐old, and 9‐month‐old with the images acquired at 12‐month‐old. Promising registration results have been achieved in terms of registration accuracy, compared with the counterpart nonlearning based registration methods.ConclusionsThe proposed new learning‐based registration method have tackled the challenging issues in registering infant brain images acquired from the first year of life, by leveraging the multioutput random forest regression with auto‐context model, which can learn the evolution of shape and appearance from a training set of longitudinal infant images. Thus, for the new infant image, its deformation field to the template and also its template‐like appearances can be predicted by the learned models. We have extensively compared our method with state‐of‐the‐art deformable registration methods, as well as multiple variants of our method, which show that our method can achieve higher accuracy even for the difficult cases with large appearance and shape changes between subject and template images.
Partitioning k‐space for cylindrical three‐dimensional rapid acquisition with relaxation enhancement imaging in the mouse brain
Authors: Spencer Noakes T. Leigh , Henkelman R. Mark , Nieman Brian J. 
Published: September 2017

Three‐dimensional rapid acquisition with relaxation enhancement (RARE) scans require the assignment of each phase encode step in two dimensions to an echo in the echo train. Although this assignment is frequently made across the entire Cartesian grid, collection of only the central cylinder of k‐space by eliminating the corners in each phase encode dimension reduces the scan time by ~22% with negligible impact on image quality. The recipe for the assignment of echoes to grid points for such an acquisition is less straightforward than for the simple full Cartesian acquisition case, and has important implications for image quality. We explored several methods of partitioning k‐space—exploiting angular symmetry in one extreme or emulating a cropped Cartesian acquisition in the other—and acquired three‐dimensional RARE magnetic resonance imaging (MRI) scans of the ex vivo mouse brain. We evaluated each partitioning method for sensitivity to artifacts and then further considered strategies to minimize these through averaging or interleaving of echoes and by empirical phase correction. All scans were collected 16 at a time with multiple‐mouse MRI. Although all schemes considered could be used to generate images, the results indicate that the emulation of a standard Cartesian echo assignment, by partitioning preferentially along one dimension within the cylinder, is more robust to artifacts. Samples at the periphery of the bore showed larger phase deviations and higher sensitivity to artifacts, but images of good quality could still be obtained with an optimized acquisition protocol. A protocol for high‐resolution (40 μm) ex vivo images using this approach is presented, and has been used routinely with a success rate of 99% in over 1000 images.
Rendezvous‐based access control for information‐centric architectures
Authors: Fotiou Nikos , Alzahrani Bander A. 
Published: September 2017

SummaryInformation‐centric networking (ICN) has been in the spotlight of many research efforts as it shifts the focus from (endpoint) locations to content items themselves. By leveraging content centrism and by using content and content names as the main pillar of all (inter‐)networking functions, ICN architectures are expected to overcome many of the limitations of the current Internet architecture. Information‐centric networking paradigm also advocates a shift in security solutions: Instead of securing the communication channel, ICN security solutions should secure the content itself. Therefore, end users should be able to access content stored in various locations in the network—even unsecured—in a private and secure way. Similarly, content owners should not lose the governance of their content items, no matter the network location where they are stored. In this paper, we design, implement, and evaluate an access control delegation mechanism for the publish‐subscribe Internet architecture. Our solution does not introduce any new entity; instead it allows semitrusted publish‐subscribe Internet rendezvous points to enforce access control policies. Moreover, our solution leverages identity‐based proxy re‐encryption to protect content confidentiality in the presences of malicious publishers, ie, nodes that host content items and do not respect the access control decisions of the rendezvous point.
Reduced‐toxicity alternate‐donor stem cell transplantation with posttransplant cyclophosphamide for primary immunodeficiency disorders
Authors: Rastogi Neha , Katewa Satyendra , Thakkar Dhwanee , Kohli Shruti , Nivargi Sagar , Yadav Satya Prakash 
Published: September 2017

AbstractWe describe here the outcomes of reduced‐toxicity alternate‐donor stem cell transplant (SCT) with posttransplant cyclophosphamide (PTCy) for primary immunodeficiency disorders (PIDs) in eight children (haploidentical—seven and matched unrelated donor—one). The conditioning was with serotherapy (alemtuzumab‐3/rabbit‐anti‐thymoglobulin‐5); fludarabine, cyclophosphamide, and total body irradiation‐5 (additional thiotepa‐3); fludarabine and treosulfan‐2; and fludarabine and busulfan‐1. All received PTCy 50 mg/kg on days 3 and 4 as graft versus host disease prophylaxis along with tacrolimus and mycophenolate. Mean CD34 dose was 13.8 × 106/kg. Two children died because of PIDs. Acute graft versus host disease up to grades I and II was seen in three children. All six survivors are fully donor and disease free at median follow‐up of 753 days. Alternate donor SCT with PTCy is feasible in PID and has good outcomes.
Antimicrobial stewardship in paediatric oncology: Impact on optimising gentamicin use in febrile neutropenia
Authors: Hennig Stefanie , Staatz Christine E. , Natanek Daniel , Bialkowski Sabina , Consuelo Llanos Paez Carolina , Lawson Rachael , Clark Julia 
Published: September 2017

AbstractObjectivesTo evaluate the impact of an antimicrobial stewardship (AMS) intervention, involving introduction of new guidelines on the treatment of febrile neutropenia (FN), on improving the use of gentamicin in paediatric oncology patients.Design and interventionUpdated guidelines for gentamicin usage in paediatrics with FN were implemented at a tertiary children's teaching hospital, in Brisbane, Australia. Data on gentamicin usage before and after the guideline change were collected retrospectively from children with cancer admitted to hospital with FN between January 2012 and December 2013. Gentamicin use, duration of gentamicin therapy and therapeutic monitoring practice were compared against bacterial culture status for admissions before and after the guideline change to assess the impact on practice.ResultsData were collected from 227 children corresponding to 453 separate admissions, 195 preguideline and 257 post‐guideline change. Following guideline change, the proportion of admissions in which gentamicin was administered reduced from 79.0 to 20.9% (P‐value < 0.001) and administrations not associated with a cultured Gram‐negative organism dropped from 87.2 to 58.2% (P‐value < 0.001), indicating a change in practice according to the new guideline. Following guideline change, admissions in which gentamicin was used for >48 hr despite the absence of a confirmed Gram‐negative infection decreased from 85.6 to 46.9% (P‐value < 0.001).ConclusionsGuideline changes driven through an AMS initiative involving paediatric oncology patients significantly improved targeted‐ and nontargeted‐antimicrobial use potentially reducing the risk of emergence of resistance against gentamicin in this cohort.
Improved protein contact predictions with the MetaPSICOV2 server in CASP12
Authors: Buchan Daniel W A , Jones David T 
Published: September 2017

AbstractIn this paper, we present the results for the MetaPSICOV2 contact prediction server in the CASP12 community experiment (http://predictioncenter.org). Over the 35 assessed Free Modelling target domains the MetaPSICOV2 server achieved a mean precision of 43.27%, a substantial increase relative to the server's performance in the CASP11 experiment. In the following paper, we discuss improvements to the MetaPSICOV2 server, covering both changes to the neural network and attempts to integrate contact predictions on a domain basis into the prediction pipeline. We also discuss some limitations in the CASP12 assessment which may have overestimated the performance of our method.
New EWMA control charts for monitoring process dispersion using auxiliary information
Authors: Haq Abdul 
Published: September 2017

AbstractThe exponentially weighted moving average (EWMA) control chart is a well‐known statistical process monitoring tool because of its exceptional pace in catching infrequent variations in the process parameter(s). In this paper, we propose new EWMA charts using the auxiliary information for efficiently monitoring the process dispersion, named the auxiliary‐information–based (AIB) EWMA (AIB‐EWMA) charts. These AIB‐EWMA charts are based on the regression estimators that require information on the quality characteristic under study as well as on any related auxiliary characteristic. Extensive Monte Carlo simulation are used to compute and study the run length profiles of the AIB‐EWMA charts. The proposed charts are comprehensively compared with a recent powerful EWMA chart—which has been shown to be better than the existing EWMA charts—and an existing AIB‐Shewhart chart. It turns out that the proposed charts perform uniformly better than the existing charts. An illustrative example is also given to explain the implementation and working of the AIB‐EWMA charts.