bluuebunny/crossref_metadata_2025_split huggingface dataset:
NFAT1 Regulates Systemic Autoimmunity through the Modulation of a Dendritic Cell Property
Authors: Chae Chang-Suk , Kim Gi-Cheon , Park Eun Sil , Lee Choong-Gu , Verma Ravi , Cho Hagg-Lim , Jun Chang-Duk , Yoo Yung Joon , Im Sin-Hyeog 
Published: October 2017

Abstract
The transcription factor NFAT1 plays a pivotal role in the homeostasis of T lymphocytes. However, its functional importance in non-CD4+ T cells, especially in systemic immune disorders, is largely unknown. In this study, we report that NFAT1 regulates dendritic cell (DC) tolerance and suppresses systemic autoimmunity using the experimental autoimmune myasthenia gravis (EAMG) as a model. Myasthenia gravis and EAMG are T cell–dependent, Ab-mediated autoimmune disorders in which the acetylcholine receptor is the major autoantigen. NFAT1-knockout mice showed higher susceptibility to EAMG development with enhanced Th1/Th17 cell responses. NFAT1 deficiency led to a phenotypic alteration of DCs that show hyperactivation of NF-κB–mediated signaling pathways and enhanced binding of NF-κB (p50) to the promoters of IL-6 and IL-12. As a result, NFAT1-knockout DCs produced much higher levels of proinflammatory cytokines such as IL-1β, IL-6, IL-12, and TNF-α, which preferentially induce Th1/Th17 cell differentiation. Our data suggest that NFAT1 may limit the hyperactivation of the NF-κB–mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance.
Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model
Authors: Bednar Kyle J. , Shanina Elena , Ballet Romain , Connors Edward P. , Duan Shiteng , Juan Joana , Arlian Britni M. , Kulis Michael D. , Butcher Eugene C. , Fung-Leung Wai-Ping , Rao Tadimeti S. , Paulson James C. , Macauley Matthew S. 
Published: October 2017

Abstract
CD22, a sialic acid–binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease. The restricted expression pattern of CD22 on B cells and most B cell lymphomas has made CD22 a therapeutic target for B cell–mediated diseases. Models to better understand how in vivo targeting of CD22 translates to human disease are needed. In this article, we report the development of a transgenic mouse expressing human CD22 (hCD22) in B cells and assess its ability to functionally substitute for murine CD22 (mCD22) for regulation of BCR signaling, Ab responses, homing, and tolerance. Expression of hCD22 on transgenic murine B cells is comparable to expression on human primary B cells, and it colocalizes with mCD22 on the cell surface. Murine B cells expressing only hCD22 have identical calcium (Ca2+) flux responses to anti-IgM as mCD22-expressing wild-type B cells. Furthermore, hCD22 transgenic mice on an mCD22−/− background have restored levels of marginal zone B cells and Ab responses compared with deficiencies observed in CD22−/− mice. Consistent with these observations, hCD22 transgenic mice develop normal humoral responses in a peanut allergy oral sensitization model. Homing of B cells to Peyer’s patches was partially rescued by expression of hCD22 compared with CD22−/− B cells, although not to wild-type levels. Notably, Siglec-engaging antigenic liposomes formulated with an hCD22 ligand were shown to prevent B cell activation, increase cell death, and induce tolerance in vivo. This hCD22 transgenic mouse will be a valuable model for investigating the function of hCD22 and preclinical studies targeting hCD22.
CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection
Authors: Patel Swapneel J. , Yokoyama Wayne M. 
Published: October 2017

Abstract
A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic CD4+ cells during neonatal infection of BALB/c mice. Despite significant disruptions to the normal adaptive immune response, infected BALB/c mice reproducibly recover from infection, consistent with prior studies on a related virus, mouse thymic virus. In this article, we show that, in contrast to published studies on mouse thymic virus, MRV appears to robustly infect neonatal C57BL/6 (B6) mice, causing severe depletion of thymocytes and peripheral T cells. Moreover, B6 mice recovered from infection. We investigated the mechanism of thymocyte and T cell loss, determining that the major thymocyte subsets were infected with MRV; however, CD4+ and CD4+CD8− T cells showed increased apoptosis during infection. We found that CD8+ T cells populated MRV-infected thymi. These CD8+ T cells expressed markers of activation, had restricted TCR repertoire, and accumulated intracellular effector proteins, consistent with a cytotoxic lymphocyte phenotype and suggesting their involvement in viral clearance. Indeed, absence of CD8+ T cells prevented recovery from MRV infection and led to lethality in infected animals, whereas B cell–deficient mice showed CD4+ T cell loss but recovered from infection without lethality. Thus, these results demonstrate that CD8+ T cells are required for protective immunity against a naturally occurring murine pathogen that infects the thymus and establish a novel infection model for MRV in B6 mice, providing the foundation for detailed future studies on MRV with the availability of innumerable mutant mice on the B6 background.
Combustion Heat Meter
Authors: Magonski Zbigniew 
Published: October 2017

Abstract
In Memoriam—In memory of Dr. Zbigniew Magonski, a talented electronic engineer and inventor, was born in Glubczyce, Poland in 1950 and passed away in Cracow, Poland in 2017. He received M.Sc. degree in Solid State Technology from the Technical University of Wrocław, Poland in 1973, and PhD degree from the AGH University of Science and Technology, Cracow, Poland in 2000. For 15 years, he was with the R&D Center for Hybrid Microelectronics, Cracow Poland. At that time, his interest was focused on hybrid A/D, D/A converters also on DC HV power converters. Later, for 28 years, he was with the Department of Electronics, AGH University of Science and Technology, Cracow, Poland. His research interests covered ceramic microfluidic systems, hydrocarbon combustors, and high-temperature solid oxide fuel cells. In 1994–1995, he was with Summit Technology, Massachusetts, involved in a project relating to HV supplying of excimer lasers. He was a member of IMAPS US Chapter, the author of 13 patents and almost 50 technical papers connected with electronic technology. He was a caring husband and father and a good friend of many of us. We will miss you, Zbyszek.
This article presents a proposal of a thermal instrument intended for the evaluation of heat energy of fluid fuels. Two thermal devices the flow meter and the combustor are the basic components of the instrument. The meter maintains a constant temperature in the vicinity of the combustion zone. The amount of heat energy in the fuel is calculated as the ratio of the electric power change expressed in Watts to the change of fuel supply delivered to the combustor within a time period of 1 s. The method enables a direct evaluation of fuel energy expressed in Joules per unit of mass or volume. For some applications, the meter may be a good alternative for a bulky bomb calorimeter.
Experimental Analysis of a Voice-Coil-Driven Jetting System for Micrograms Fluid Depositions in Electronics Assembly
Authors: Iyer Rajiv L. , Santos Daryl L. 
Published: October 2017

Abstract
The fundamental ability to drive automatically to independent locations and deposit controlled masses of electronics packaging adhesives makes dispensing an attractive solution in the electronics assembly. The existence of modern technology such as smartphones, wearable devices (watches, glasses, etc.), and tablets have led to tightly spaced, and high-density component packaging which further causes complex designs in the Printed Circuit Board (PCB) assembly. Advancements in dispensing technology because of these growing challenges in assembly has led to use of jetting systems in this new arena. The process of jetting, unlike traditional dispensing, has the ability to deposit controlled masses of packaging adhesives (also known as packaging fluids) at tightly spaced locations with high accuracy and high speed and at much higher deposition heights from the substrate. In this article, a voice-coil-driven jetting system is studied to assess the capability of jetting micrograms of electronics packaging fluids. The article presents experimental analyses to study jetting of micrograms of fluid droplets. Critical input factors are evaluated using a split-plot design of experiment (DOE) model to understand their significance in governing the responses. The responses studied in this work are the following: mass per droplet, dot diameter, and dispense quality. The applied DOE model will assist in developing prediction models to determine the optimal combination of factors in achieving desired responses.
The Oscillatory Hyper-Hilbert Transform Associated with Plane Curves
Authors: Li Junfeng , Yu Haixia 
Published: October 2017

AbstractIn this paper, the bounded properties of oscillatory hyper-Hilbert transformalong certain plane curves γ(t),are studied. For general curves, these operators are bounded in L2() if β ≥ 3α. Their boundedness in Lp() is also obtained, whenever β > 3α and .
Remix Multilingualism
Authors: Williams Quentin 
Published: October 2017

“Remixing multilingualism” is conceptualised in this book as engaging in the linguistic act of using, combining and manipulating multilingual forms. It is about creating new ways of ‘doing’ multilingualism through cultural acts and identities and involving a process that invokes bricolage. This book is an ethnographic study of multilingual remixing achieved by highly multilingual participants in the local Hip Hop culture of Cape Town. In globalised societies today previously marginalized speakers are carving out new and innovating spaces to put on display their voices and identities through the creative use of multilingualism.
This book contributes to the development of new conceptual insights and theoretical developments on multilingualism in the global South by applying the notions of stylization, performance, performativity, entextualisation and enregisterment. This takes place through interviews, performance analysis and interactional analysis, showing how young multilingual speakers’ stage different personae, styles, registers and language varieties.
Sir Gowther's Canine Penance: Forms of Animal Asceticism from Cynic Philosophy to Medieval Romance
Authors: Zacher Samantha 
Published: October 2017

Abstract
This article examines the extraordinary penance prescribed to Sir Gowther, which permits him to eat only food that is received from “the mouths of dogs” and forbids him from communicating in human language. There has been much debate as to whether Gowther's canine performance should be understood as symbolic or literal, performed or essential, rehabilitative or punitive. Drawing on previously unexplored analogues from the Perceval/Parzival cycle in which sinful knights undergo comparable canine performances, this article argues that Gowther's penance represents a rehabilitative and curative “technology of the self.” Moreover, it demonstrates that the ultimate inspiration for Gowther's penance derives from the legends of the Cynics, who advocated living life in the manner of dogs and according to the barest possible forms of animal existence. In the final analysis, the tale of Sir Gowther embraces a view of animality that rejects the normative hierarchy God–human–animal, and posits a surprising inversion: God–Christian–animal–sinner.
Producción y calidad de forraje con enmiendas orgánicas en pastura (Brachiaria Brizantha), en la Costa Caribe Sur de Nicaragua
Authors: López García Franklin Ariel , Miranda Jarling Alberto , Calero Borge Wilson Antonio 
Published: October 2017

Esta investigación se ha aplicado diferentes alternativas orgánicas para determinar sus efectos en la producción y calidad de forraje en Brachiaria brizantha. En el estudio se evaluaron tres tipos de enmiendas orgánicas (Lombrihumus, Bokashi y EM) en el pasto Brachiaria brizantha, las que fueron comparados con un tratamiento testigo (sin enmienda orgánica). Se empleó un diseño de bloque completamente al azar (BCA), 4 réplicas por tratamiento para un total de 16 parcelas, evaluado en pasturas ya establecidas. La mayor producción de biomasa verde es de 17,325 kg/ha al aplicar lombrihumus, en producción de materia seca el lombrihumus obtuvo el mayor rendimiento (3,383 kg/ha). La mayor longitud de raíces primarias se obtuvo al aplicar lombrihumus (17.25 cm). En la variable relación hoja/tallo los mayores resultados se obtuvieron con Lombrihumus. Con bokashi se obtuvieron los mayores porcentajes de digestibilidad de la materia seca (62%), proteína bruta (9.8%) y cenizas (9.52%). El lombrihumus y bokashi ejercieron los mayores efectos en las variables evaluadas en Brachiaria brizantha. Se recomienda el uso de alternativas orgánicas para optimizar la producción y calidad de la pastura Brachiaria brizantha. Abstract
EMISSÕES DE GASES DO EFEITO ESTUFA DA QUEIMA DE PELLETS DE MADEIRA
Authors: Garcia Dorival Pinheiro , Caraschi José Cláudio , Ventorim Gustavo 
Published: October 2017

As previsões indicam crescimento do uso da biomassa florestal como recurso energético nos próximos anos, sobretudo depois dos recentes acordos firmados pela Cúpula do Clima em Paris (COP21), que apontam a necessidade de substituir combustíveis fósseis por fontes renováveis e de baixas emissões de gases do efeito estufa (GEE). Há poucos estudos relacionando a combustão dos pellets de madeira com os limites dessas emissões estabelecidos para a biomassa florestal. Este estudo comparou as emissões da combustão dos pellets com os limites máximos estabelecidos na Resolução nº 436 do CONAMA. Utilizou-se quatro amostras de pellets de madeira e três biomassas florestais (casca de pinus, cavacos de pinus e serragem de eucalipto). Para a combustão foi utilizado um queimador de biomassa vegetal, com alimentação automática e consumo de 14 kg por hora. As análises das emissões foram realizadas com o analisador eletroquímico Unigas 3000 MKIII, que determinou a composição química dos gases da combustão. Os resultados mostraram que os pellets de madeira têm baixas emissões de CO, NOx e SOx. Assim, conclui-se que as biomassas florestais atendem aos limites de emissões gasosas estabelecidos pela legislação vigente, com exceção da serragem de eucalipto e a casca de pinus.
First-Time Sports-Related Concussion Recovery: The Role of Sex, Age, and Sport
Authors: Neidecker John M. , Gealt David B. , Luksch John R. , Weaver Martin D. 
Published: October 2017

Abstract

Background
Concussion is one of the most common injuries in athletes. Current concussion consensus statements propose that female sex may be a modifying factor in concussion management and recovery.

Objective
To determine whether female athletes in middle school and high school with a first-time, sports-related concussion remained symptomatic longer than their male counterparts.

Methods
A retrospective medical record analysis was performed among athletes who sustained a concussion between 2011 and 2013. Inclusion criteria consisted of age between 11 and 18 years and diagnosis of first-time concussion sustained while playing organized sports. Using the documented notes in the medical record, length of time that each athlete was symptomatic from his or her concussion was calculated.

Results
A total of 110 male and 102 female athletes (N=212) met the eligibility criteria for the study. A significant difference was found in the median number of days female athletes remained symptomatic (28 days) when compared with male athletes (11 days) (P<.001). No statistically significant difference was found in symptom duration between age groups. When matched for sex, no statistically significant differences were found in symptom duration between the type of sports played.

Conclusion
Female athletes aged 11 to 18 years with first-time, sports-related concussions remained symptomatic for a longer period when compared with male athletes of similar age, regardless of sport played. The mechanism behind this difference needs to be further elucidated.
Assessment on the coupling effects of drip irrigation and organic fertilization based on entropy weight coefficient model
Authors: Zhong Fenglin , Hou Maomao , He Bizhu , Chen Iouzen 
Published: October 2017

Water and fertilizer are two important factors influencing crop growth, development and yield formation. To investigate their combined effects on the soil-plant system, and to find out the optimal water and organic fertilizer coupling strategy for tomato (Solanum lycopersicumL), an experiment was carried out from May to October in 2016 in the south of China. The experiment consisted of three drip irrigation quotas (150, 180, 210 m3/ha) and three organic fertilizer application amounts (2,800, 3,600, 4,400 kg/ha). A water-fertilizer treatment (abbreviated as CK) that is in line with local practice was used for comparison. The tomato marketable yield, sugar/acid ratio (SAR) and irrigation water use efficiency (IWUE), as well as the soil salinity and available nutrient concentrations were measured. The results showed that the marketable yield was highly significantly (p < 0.01) affected by irrigation or fertilization. The SAR of tomato were significantly (p < 0.05) affected by irrigation or/and fertilization. The fertilization had an highly significant (p < 0.01) effect on the concentrations of soil nutrients (N, P, K), while the coupling effect of irrigation and fertilization was not pronounced. According to the multi-index analysis and the computed result by the entropy weight coefficient model, a 180 m3/ha irrigation quota in combination with 4,400 kg/ha organic fertilizer application amount was the optimal water-fertilizer coupling strategy which owned the most satisfactory comprehensive benefits. The marketable yield, SAR and IWUE under this optimal strategy were 122.4 t/ha, 9.2, 32.4 kg/m3, respectively, and by 28.0%, 29.6% and 28.1% higher compared to that under CK.
Vertical Integration and Care Experiences Among Medicare Advantage Beneficiaries
Authors: Bejarano Geronimo , Ryan Andrew , Trivedi Amal , Meyers David J. 
Published: October 2024

ImportanceMedicare Advantage (MA) beneficiaries are increasingly enrolling in integrated MA plans. Legacy-integrated plans share unique features that may differ from newer integrated MA plans. It is unclear whether integrated and legacy-integrated MA plans are associated with a better beneficiary care experience compared with non–legacy-integrated and nonintegrated MA plans.ObjectiveTo assess whether enrollment in integrated, legacy-integrated, non–legacy-integrated, and nonintegrated MA plans is associated with better beneficiary care experiences.Design, Setting, and ParticipantsThis cross-sectional study included MA beneficiaries who responded to Consumer Assessment of Healthcare Providers and Systems (CAHPS) surveys conducted annually between 2015 and 2019. Data analysis was performed between October 1, 2023, and July 31, 2024.ExposureMedicare Advantage plan integration status, categorized as integrated, legacy-integrated, non–legacy-integrated, and nonintegrated.Main Outcomes and MeasuresThe CAHPS surveys assessed 9 care experience measures. To assess differences in care experience measures, mixed linear regression analyses were performed, adjusting for demographic characteristics, plan random effects, and state fixed effects.ResultsThe sample consisted of 857 695 respondents. Their mean (SD) age was 72.6 (10.3) years, and 58.1% were women. A total of 12.7% of respondents were Black, 10.7% were Hispanic, and 71.0% were White. Compared with respondents in nonintegrated MA plans, respondents in integrated MA plans were younger (mean [SD] age, 72.7 [10.3] vs 72.2 [10.3] years, respectively) and were less likely to be Black (13.1% vs 11.2%, respectively), female (58.4% vs 57.2%, respectively), and partially dual eligible (8.7% vs 6.2%, respectively). Integrated MA plans were associated with meaningfully better mean ratings only of customer service (1.6 points [95% CI, 1.1-2.1]) and health plan (1.0 points [95% CI, 0.6-1.5]) compared with nonintegrated MA plans. Legacy-integrated MA plans were associated with meaningfully better mean ratings of drug plan (3.7 points [95% CI, 2.4-5.0]), health plan (3.1 points [95% CI, 1.7-4.5]), customer service (2.8 points [95% CI, 1.3-4.4]), getting appointments and care quickly (2.6 points [95% CI, 1.2-4.0]), health care quality (1.9 points [95% CI, 1.0-2.7]), physicians who communicate well (1.1 points [95% CI, 0.4-1.8]), and care coordination (1.1 points [95% CI, 0.4-1.9]) compared with nonintegrated MA plans.Conclusions and RelevanceIn this study, integrated MA plans were not associated with better beneficiary care experiences compared with nonintegrated MA plans. Legacy-integrated MA plans were associated with higher ratings on all care experience measures compared with both non–legacy-integrated and nonintegrated MA plans. Monitoring of integrated MA plans is needed to assess whether they are adding meaningful value to MA beneficiaries and to determine their effects on the health care system.