bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic factors for recurrence of locally advanced differentiated thyroid cancer
Authors: Kim Bo‐Young , Choi Ji‐Eun , Lee Eunkyu , Son Young‐Ik , Baek Chung‐Hwan , Kim Sun Woo , Chung Man Ki 
Published: June 2017

Background and Objectives To present treatment outcomes and prognostic factors for surgical management of locally advanced differentiated thyroid cancer (DTC).MethodsRetrospective review of 70 patients in a single, tertiary referral institution was done. Clinical pathology characteristics were analyzed to investigate prognosticators, based on primary endpoints; locoregional recurrence alone (LRR), total recurrence (LRR or distant metastasis (DM)), and recurrence‐free survival.ResultsRecurrent laryngeal nerve (n = 31) and trachea (n = 30) were most commonly invaded organs by tumor. At the mean follow‐up of 81.7 months, LRR occurred in 15 patients and/or DM was detected in 15 patients (10 developed LRR and DM). By multivariate analysis, R1 resection (positive margin) and pN1b stage increased risk of LRR with a fold of 3.16 [95%CI 1.08‐9.24, P = 0.03] and 5.92 [1.61‐21.7, P = 0.007], respectively. Also, they increased risk of total recurrence with a fold of 3.04 [95%CI 1.26‐7.31, P = 0.01] and 3.42 [95%CI 1.16‐10.0, P = 0.02], respectively. Patients with pN1b stage showed better LRR‐free survival than pN0/N1a stage (P = 0.03).ConclusionsAlong with careful preoperative evaluation of the extent of primary and neck disease, obtaining negative resection margin and aggressive neck management is critical to improve oncologic outcomes of locally advanced DTC.
Factors associated with thromboembolic events following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Authors: Rottenstreich Amihai , Kalish Yosef , Kleinstern Geffen , Yaacov Almog Ben , Dux Joseph , Nissan Aviram 
Published: June 2017

Background and ObjectivesWe investigated the risk factors, incidence, and role of thromboprophylaxis in the development of thrombosis following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).MethodsWe reviewed data of patients with CRS/HIPEC in three hospitals.ResultsOverall, 192 patients underwent CRS/HIPEC during 2007‐2016. Mechanical (thigh‐length pneumatic compression stockings) and pharmacologic thromboprophylaxis (40 mg enoxaparin daily, starting 12 h before surgery until discharge) was provided for all patients; and 116 (60.4%) also received an extended course of enoxaparin for 2‐4 weeks after discharge. Twenty‐six patients experienced thrombotic complications (13.5%) including portal‐splenic‐mesenteric venous thrombosis (n = 11, 5.7%), pulmonary embolism (n = 10, 5.2%), and deep vein thrombosis (n = 5, 2.6%); most (n = 21, 80.8%) occurred after hospital discharge. Univariate analysis identified Peritoneal Cancer Index, intraoperative transfusion requirement, operative blood loss, operative time, lengths of hospital, and intensive care unit stay, and lack of administration of anticoagulation at discharge as significantly associated with thrombosis. With multivariate analysis, only the lack of anticoagulation therapy at discharge remained significantly associated with thrombosis (P = 0.0001).ConclusionsThromboembolic complications are common following CRS/HIPEC. As significantly lower rates of thrombosis were found in patients who received an extended course of anticoagulation, we support its use for at least 2 weeks after discharge.
US‐guided core‐needle biopsy versus US‐guided fine‐needle aspiration of suspicious cervical lymph nodes for staging workup of non‐head and neck malignancies: A propensity score matching study
Authors: Ryu Kyeong Hwa , Lee Jeong Hyun , Jang Seung Won , Kim Hwa Jung , Lee Ji Ye , Chung Sae Rom , Chung Mi Sun , Kim Hyo Weon , Choi Young Jun , Baek Jung Hwan 
Published: June 2017

Background and ObjectivesTo compare US‐guided core‐needle biopsy (USCNB) and US‐guided fine‐needle aspiration (USFNA) of suspicious cervical lymph nodes for staging workup of malignancies in locations other than the head and neck using propensity score matching (PSM).MethodsThis retrospective cohort study included 108 patients who underwent USFNA and 1058 who underwent USCNB for suspicious cervical lymph nodes detected by imaging modalities during the staging workup for malignancies located in regions other than the head and neck. The primary outcome was defined as the inconclusive results. To evaluate the procedures according to the outcome, we performed univariate and multivariate logistic regression analyses and a 1:1 PSM of USCNB and USFNA.ResultsThere was no complication for both USFNA and USCNB. The inconclusive results were 6.5% (7/108) for USFNA and 1.6% (17/1058) for USCNB. A significantly lower rate of the inconclusive results in USCNB than in USFNA before matching was maintained after a 1:1 PSM of 103 patients from each group (before PSM, odds ratio (OR) = 4.489, 95% confidence interval (CI) [1.803‐11.177], P = 0.001; after PSM, OR = 1.060, 95%CI [1.013‐1.109], P = 0.012).ConclusionsBecause USCNB can reduce inconclusive results compared to USFNA, it could be more helpful for staging workup of malignancies in locations other than the head and neck in patients with suspicious cervical lymph nodes.
Winter and summer weather modulate the demography of wild turkeys at the northern edge of the species distribution
Authors: Lavoie Maxime , Blanchette Pierre , Larivière Serge , Tremblay Jean‐Pierre 
Published: June 2017

AbstractTemperate species occupying habitats at the northern limit of their geographical distribution are limited by weather and climatic conditions. Such conditions often directly affect population dynamics, and thus, influence shifts in distribution via changes in demographic parameters. We examined this question by following three distinct populations of wild turkeys inhabiting areas exposed to a gradient of meteorological conditions at the northern limit of the species distribution. Four years of radio‐telemetry on 181 birds and monitoring of 95 nests revealed that population demographics of wild turkeys were influenced by snow depth, winter temperature and summer rainfall. During winter, survival of turkeys decreased drastically when snow depth remained >30 cm for >10 days and also decreased as temperatures got colder. In the spring, snow persistence delayed nest initiation, whereas nest survival was negatively affected by rainfall. Our findings show that the effects of critical meteorological factors such as snow and temperature can be compounded when both reach the limit of a species tolerance simultaneously.
The Impact of Screening Psychiatric Comorbidity and High-risk Feedback on Liaison Psychiatric Consultation Rates and Clinicians’ Attitudes on a Neurology Ward
Authors: Van Damme R. , Portzky G. , Boon P. , Lemmens G.M.D. 
Published: June 2017

IntroductionLifetime prevalence of psychiatric comorbidity in neurological patients is as high as 55%, but it remains often undetected and therefore untreated in hospital settings. Further, clinicians tend to make little use of the consultative and liaison psychiatric team for detection and treatment of anxiety and mood disorders in neurological patients. The current study aimed to investigate whether the implementation of a stepped screening protocol with high risk feedback to the clinician had an influence on the use of consultative and liaison psychiatric services.MethodAll patients admitted to the neurological ward were assessed using a stepped screening protocol for depression, anxiety and substance use during 15 months. Positive screening resulted in feedback to the clinicians depending on the study phase (e.g. feedback vs. no feedback).ResultsNo differences were found in the use of consultative and liaison psychiatric services during the non-feedback and feedback phase.ConclusionScreening and high risk feedback of psychiatric comorbidity in neurological patients does not increase psychiatric referral rates. It points to the necessity of a more integrated collaborative care model for detection and treatment of psychiatric comorbidity.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Structural Brain Abnormalities in Early Onset Psychosis: Results from Nhe norment eop Cohort
Authors: Lonning V. , Nerland S. , Smelror R.E. , Gurholt T.P. , Agartz I. 
Published: June 2017

IntroductionCortical brain abnormalities are frequently observed in adults with psychotic disorders, but few studies have investigated adolescents with early-onset psychosis (EOP). A previous magnetic resonance imaging (MRI) study from the NORMENT group in Norway, found widespread cortical thinning and smaller subcortical volumes in adult patients with psychotic disorders, particularly schizophrenia, compared to healthy controls.MethodsParticipants from the ongoing NORMENT adolescent EOP-study, 30 patients (age: 13.3–18.3 years, mean age: 16.5, 66% female) and 45 healthy adolescents (age: 13.6–18.8 years, mean age: 16.2, 58% female), underwent 3 T MRI on the same scanner. Surface-based morphometric analyses were performed using FreeSurfer version 5.3.0. Group differences in vertex-wise cortical volume, thickness and surface area were investigated by fitting general linear models at each vertex on the surface. Age, sex and group were entered as covariates, and a non-parametric cluster-wise correction method for multiple comparisons was applied and cluster-forming and cluster-wise threshold set at 0.05.ResultsPreliminary results show thinner cortex in the left medial frontal lobe and smaller surface area in the left temporoparietal junction in EOP patients compared to healthy controls after correction for multiple comparisons.ConclusionSurface-based analysis is sensitive to alterations in cortical morphology in an adolescent EOP sample. The regions exhibiting reduced cortical thickness and area in EOP overlap with findings in an adult psychosis sample. Large-scale studies are warranted to better identify the pattern of abnormalities and clarify effects of age, diagnosis and medication.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Insulin Resistance and Telomere Length in Treatment of Depressive Disorders
Authors: Rasgon N. , McEwen B. , Lin K.W. 
Published: June 2017

Insulin resistance and markers of Allostatic load in depressionIntroductionAmong patients with major depression, increased inflammatory markers at baseline may predict an anti-depressant response. Reducing inflammation may augment response to psychotropic medications. Few studies have investigated an association between Leukocyte Telomere Length (LTL) and therapeutic response in depression, reporting mixed results. No studies assessed LTL and treatment response with PPAR-γ agonists.Objectives(1) LTL as a predictor of anti-depressant response to PPAR-γ agonist in patients with unremitted depression.(2) the correlation between LTL and insulin resistance (IR) status.AimsWe aimed to assess LTL as a predictor of antidepressant response to Pioglitazone in groups of insulin resistant and insulin-sensitive subjects using surrogate markers of IR.MethodsMedically stable men and women (n = 42) ages 23–71 with non-remitted depression participated in double-blind placebo controlled add-on of Pioglitazone to treatment-as-usual. Oral glucose tolerance tests were administered at baseline and at 12 weeks.ResultsAt baseline, no differences in LTL were detected by depression severity, duration or chronicity. LTL was also not significantly different between insulin-resistant and insulin-sensitive subjects. Subjects with longer telomeres exhibited greater declines in depression severity in the active arm, but not in a placebo arm. LTL also predicted improvement in insulin sensitivity in the group overall and did not differ between the active and placebo arm.ConclusionsLTL may emerge as a viable predictor of antidepressant response. An association between insulin sensitization and LTL regardless of the baseline IR status points to potential role of LTL as a non-specific moderator of metabolic improvement in these patients.Disclosure of interestI, Dr. Natalie Rasgon, am a consultant for Shire Pharmaceuticals and Sunovion Pharmaceuticals.
Conceptual Aspects of Mental Health in its Intersection with Human Rights and Development
Authors: Galderisi S. 
Published: June 2017

IntroductionImproving mental health of people is an important goal of the present millennium. Community-based services programs for prevention of mental disorders and promotion of mental health have been implemented in several countries. However, the proportion of people suffering from mental disorders is significantly and persistently high, and psychosocial distress due to migration, natural disasters, and terrorism; in general, feeling of insecurity is unlikely to improve current figures.AimsTo highlight the interrelatedness of mental health, development and human rights, in particular in women and girls.MethodsThe presentation will consider conceptual aspects of mental health in its intersection with human rights and development, with particular reference to women and girls.ResultsCurrent definitions of mental health might be misleading and convey the false expectation that mental health coincides with happiness and productivity. An alternative conceptual framework will be presented, in which mental health is a dynamic state of internal equilibrium that enables individuals to use their abilities in harmony with universal values of society. Different factors concur to the dynamic equilibrium, and will be discussed in their intersection with human rights and development, with particular reference to the most frequent violations of human rights (e.g. trafficking, domestic abuse, sexual violence) that contribute to increase the risk of mental disorders in women and girls.ConclusionMental health is rooted in personal development and social context in which the person lives. Strategies aimed to address mental health in women and girls will need to consider gender, country and socio-cultural specificities.Disclosure of interestHonoraria or Advisory board/consulting fees from the following companies: Lundbeck, Janssen Pharmaceuticals, Hoffman-La Roche, Angelini-Acraf, Otsuka, Pierre Fabre and Gedeon-Richter.
The Needs of Women Users of Mental Health Services and their Families
Authors: Amering M. 
Published: June 2017

AimUnderstand the needs of women users of mental health services and their families and discuss consequences.MethodNon-systematic review of concepts and data regarding the needs of women users of mental health services and their families.Resultsnequity and inefficiency of mental health resources affect men and women all around the globe. Some important mental health needs as well as barriers to care are gender-specific. Women have specific needs in specific phases of life, e.g. the perinatal period, as well as specific risk factors, e.g. interpersonal violence and sexual abuse. Developments of women only services as well as the implementation of gender-specific approaches in routine care are underway and need to be evaluated, amended and expanded. Training as well as research requirements are numerous and urgent. Family carers are an essential mental health resource. A majority is female with significant unmet needs. Family advocacy in mental health is prominently supported by female activists as is the psychiatric user movement. Because of the cumulation and the interaction of gender-based and other forms of discrimination, legislations such as those following the UN-Convention on the rights of persons with disabilities include specific provisions for women and girls with psychosocial disabilities.ConclusionsMental health stigma and discrimination interact with gender inequality and the discrimination of women and girls to their mental health detriment. Clinical and scientific responsibilities in mental health essentially include gender-specific attention to the needs of women and girls and their families.Disclosure of interestThe author has not supplied his declaration of competing interest.
The Role of Long Acting Antipsychotics in Bipolar Disorder
Authors: Vieta E. 
Published: June 2017

Antipsychotics are widely used for the short and long-term treatment of bipolar disorder. Depot and long-acting injectable formulations (LAIs) can be particularly useful for certain subgroups of patients. This lecture will discuss the available data from randomized controlled trials of LAIs in bipolar disorder. A recently published meta-analysis and individual studies assessing depot medications, as well as modern LAIs such as risperidone, paliperidone and aripiprazole, will be reviewed, looking carefully into the prevention of either pole of illness and tolerability. Potential indications and patient profile, based on data and clinical experience, will be discussed.Disclosure of interestThe author has not supplied his declaration of competing interest.
A Pilot Study on Posttraumatic Stress Disorder Prevalence in Asylum Seeker in Primary Reception Setting
Authors: Vaccino N. , Signorelli M.S. , Rodolico A. , Riso M.C. , Aguglia E. 
Published: June 2017

IntroductionSocial, political and health related effects of “European migrant crisis” are challenging our Old Continent, not always capable to address immigrants’ needs.ObjectivesOur main purpose is to estimate the prevalence of post-traumatic stress disorder among asylum seekers arriving in Italy.MethodsWe designed a cross-sectional study for prevalence estimation in a reception centre where asylum seekers stay for their first period in Italy. They are given hospitality until the possibility of their permanence is verified. We created a survey asking for general information. Participants also received PTSD Checklist (PCL-C). In our analysis, we adopted 45 as cut-off for diagnosis. Questionnaires have been delivered house-to-house and collected when completed.ResultsIn this pilot study, we collected 61 questionnaires. The majority of answers came from male subjects (46). The prevalence of PTSD was 44% (47% among men and 53% among women, not statistically different).ConclusionsSo high rate of PTSD depicts a reality that cannot be left apart. Our attention toward immigrants must focus also on their mental health. European Union should consider new solutions to take care of these critical aspects of those.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Is Borderline Personality Disorder a Neuroendocrine Disease?
Authors: Ferreira C. , Alves S. , Oliveira C. , Avelino M.J. 
Published: June 2017

IntroductionBorderline personality disorder (BPD) is a disabling heterogeneous psychiatric disorder characterized by poor affect regulation and impulse control, with a high reactivity and vulnerability to stress. It has been hypothesized that these patients may have a dysregulation of the neuroendocrine system.AimsThe goal of this work is to systematically review the scientific knowledge regarding the role of the neuroendocrine system in the physiopathology of BPD.MethodsThe literature was reviewed by online searching using PubMed®. The authors selected scientific papers with the words “borderline personality disorder” and “neuroendocrine”/“endocrine” in the title and/or abstract, published in English.Results and discussionThere is scientific evidence for an enhanced cortisol release and HPA axis hyperactivity in BPD. The dexamethasone suppression test has been used in BPD, finding high rates of non-suppressors in that sample. There also seems to be a reduced volume of the amygdala and anterior cingulate cortex, suggesting an involvement of those regions in the emotional disturbances in BPD. Symptoms of impulsivity, aggression and suicidal behavior seem to be strongly mediated by the serotonergic system. The available research suggests a serotoninergic dysfunction in BPD, with lower levels of serotonin in those patients.ConclusionsThere seems to be several neuroendocrine changes related to BPD, namely a hyperactivity of the HPA axis with stimulated cortisol release together with disturbances of the serotonergic system. Also some brain structural alterations in BPD are scientifically depicted. Further studies are needed to clarify the neurobiology of BPD improving both psychotherapeutic and psychopharmacological treatment in these patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Anxiety and Depression among Elderly Hemodialyzed Patients
Authors: Feki R. , Trigui D. , Abida I. , Baati I. , Sellami R. , Feki I. , Masmoudi J. 
Published: June 2017

IntroductionThe haemodialysis, one of the main treatment modalities of chronic renal failure, imposes a great psychosocial burden on elderly patients, which may cause many psychological impacts.ObjectiveThe aim of this study was to screen anxiety and depression in elderly patients on haemodialysis, taking into account factors that may contribute to.MethodsOur study was transversal, descriptive carried out among 38 elderly patients aged more than 60 years with chronic kidney failure on haemodialysis. The structured questionnaire used in this study was gathered information on socio-demographic and disease characteristics. We used the hospital anxiety and depression scale (HADS) to access anxiety and depression.ResultsThe mean age of our sample was 71 years. The sex-ratio (♂/♀) was 1.92.,patients were mainly married (73.7%), and have a low school level (76.3%). The mean haemodialysis duration was 5 years ± 4.68. The most common cause of renal failure was polycystic kidney disease (18.4%), diabetes (15.8%), while in 28.9% the cause was unknown. Anxiety was found in 18.4% of patients and it was associated with both low school (P = 0.02) and socio-economic level (P = 0.04). The prevalence of depressive symptoms was 42.1%. It was correlated to the unknown cause of kidney failure and the short duration haemodialysis (P = 0.03).ConclusionThese data suggest that depression and anxiety are highly prevalent in elderly patients with renal failure on dialysis. This result shows the need for interdisciplinary teamwork in improving the quality of life of those patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Risk of Suicidal Behaviours in Elderly
Authors: Goretti S. , Sanchéz Sanchéz M.D.C. , Góngora Oliver B. , Sanz Fernández M.D. 
Published: June 2017

IntroductionOlder adults constitute the age group in which suicide more often reaches its most categorical expression: consummation.ObjectiveIdentify risk factors for suicide in older people.MethodSystematic review of the literature on the subject. The databases consulted were Dialnet and Pubmed. The descriptors used have been: “suicide”, “risk factors” and “elderly”, accepting the works found in English and Spanish, with a total of 501 references found after the search, from which 75 have been selected.ResultsAs shown in the reviewed studies, there is a progressive increase in suicide rate with age in males. The purpose of dying in the old man is usually characterized by his firm conviction, not infrequently reflexive and premeditated. In the multifactorial etiology of suicidal behaviour in this age group, the main elements to be considered would be psychosocial factors, psychiatric diseases and chronic somatic diseases, resulting in a potentiation among them due to their frequent interaction. The feeling of abandonment, the feeling of emptiness, the despair of the organic collapse and the self-perception of being a useless person, without projects, generates deterioration in the quality of life.ConclusionsIn the multifactorial etiology of the suicidal behaviour of the elderly, they usually play coprotagonic roles, loneliness, isolation, somatic illness and depression. The most likely profile of the suicidal elder would be represented by a man with a history of depressive episode after age 40, who lives alone, with a family history of depression or alcoholism and a recent loss.Disclosure of interestThe authors have not supplied their declaration of competing interest.