bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of Cervical Nodal Metastasis in Early-Stage Squamous Cell Carcinoma of the Tongue
Authors: Ahmed Sadaf , Junaid Montasir , Awan Sohail , Kazi Maliha , Khan Hareem , Halim Sohail 
Published: June 2017

Introduction Oral cavity carcinoma is an aggressive tumor, with the tongue being one of the most common subsites of involvement. Surgery is a gold standard method of dealing with advanced-stage tumors. However, for early-stage carcinomas of the tongue, the management remains controversial. Several studies have indicated that early-stage cancers have a high chance of occult cervical node metastasis, which, if left untreated, can greatly affect the prognosis. Certain parameters can help identify patients with occult cervical node metastases, and can avoid unnecessary neck dissection in node negative patients. Tumor thickness is one such objective parameter.
Objective To estimate the frequency of cervical lymph node metastasis in patients with early-stage, node-negative (N0) squamous cell carcinoma of the tongue.
Methods In-patient hospital data was reviewed from January 2013 until March 2014, and 78 patients who underwent primary resection of the tumor and neck dissection for biopsy-proven, early stage squamous cell carcinoma of the tongue were included. Data such as tumor thickness, tumor differentiation and presence of occult nodal metastasis in the surgical specimen were gathered from the histopathology reports. The frequency of subclinical cervical lymph node metastasis in patients with early-stage squamous cell carcinoma of the tongue was estimated.
Results A total of 69% of the patients with tumor thicknesses > 5 mm had tumor metastases in the neck nodes, while 100% of the patients with tumor thicknesses < 5 mm had no neck nodal metastasis.
Conclusion A tumor thickness > 5 mm is significantly associated with subclinical metastasis, and prophylactic neck dissection is warranted in such cases.
Telemetric Intracranial Pressure Recording via a Shunt System Integrated Sensor: A Safety and Feasibility Study
Authors: Hermann Elvis , Heissler Hans , Krauss Joachim , Ertl Philipp 
Published: June 2017

Background The dynamics of intracranial pressure (ICP) after shunt surgery in patients with normal pressure hydrocephalus (NPH) are poorly known. Temporarily implanted parenchymal pressure probes are reliable for accurate ICP monitoring; however, a disadvantage of this method is that the ICP probe has to be explanted after a period of time, requiring additional surgery. We present two patients with NPH with an integrated ICP measuring device in the shunt system that allows for long-term postoperative telemetric monitoring of ICP.
Methods Two patients (one man, 66 years old, and one woman, 78 years old) with normal pressure hydrocephalus underwent shunt surgery using the Aesculap-Miethke Sensor Reservoir (Potsdam) as an ICP measuring device integrated in the shunt system. On the first postoperative day and during follow-up examination 3 months later, several measurements of ICP were performed using a handheld device to read the Sensor Reservoir data. Postural changes such as lying down, sitting, and standing with different head postures were assessed according to an experimental protocol in a randomized order during which the ICP was measured.
Results There were clear ICP responses due to postural changes, in line with physiologically expected values. Because the highest sampling rate of the Aesculap-Miethke Sensor Reservoir is 1 Hz for continuous measurement of ICP, however, the collected data have to be considered an approximation for actual ICP dynamics.
Conclusion The Aesculap-Miethke Sensor Reservoir is an easy-to-use tool to measure ICP changes reliably in patients with a shunt system. The sampling rate and handling of data acquisition may eventually be developed further.
„Nee, mach ich nicht!“
Authors: Gustke Helge 
Published: June 2017

Zusammenfassung
Welchen Beitrag die Familiengesundheitspflege zur Therapieeinhaltung leisten
kann Häufig erleben Pflegende im Berufsalltag, dass Kinder und Eltern im
Lebensalltag Therapievorgaben unzureichend oder gar nicht umsetzen. Um dieses
Phänomen zu verstehen und pflegerisch angemessen darauf reagieren zu können,
müssen Pflegende sich mit den Ursachen und Hintergründen für dieses Verhalten
und den Folgen einer chronischen Erkrankung im Kindes- und Jugendalter für die
Erkrankten und deren Familie auseinandersetzen.
Funktionelle Herzbeschwerden osteopathisch betrachtet
Authors: Schmid Gordian Lukas 
Published: June 2017

ZusammenfassungDieser Artikel erläutert ausgehend von funktionellen Störungen des Herzens dessen vegetative Innervation und betrachtet dann mögliche
Verbindungen parietaler und faszialer Dysfunktionen mit einer gestörten Balance von Sympathikus und Parasympathikus. Schließlich werden
Sinnhaftigkeit und Möglichkeiten für eine unterstützende osteopathische Behandlung für funktionelle Herzbeschwerden diskutiert.
Cytoprotective Effects of Pumpkin (Cucurbita Moschata) Fruit Extract against Oxidative Stress and Carbonyl Stress
Authors: Shayesteh Reyhaneh , Kamalinejad Mohammad , Adiban Hasan , Kardan Azin , Keyhanfar Fariborz , Eskandari Mohammad 
Published: June 2017

Abstract
Background Diabetes mellitus is a chronic endocrine disorder that is associated with significant mortality and morbidity due to microvascular and macrovascular complications. Diabetes complications accompanied with oxidative stress and carbonyl stress in different organs of human body because of the increased generation of free radicals and impaired antioxidant defense systems. In the meantime, reactive oxygen species (ROS) and reactive carbonyl species (RCS) have key mediatory roles in the development and progression of diabetes complications. Therapeutic strategies have recently focused on preventing such diabetes-related abnormalities using different natural and chemical compounds. Pumpkin (Cucurbita moschata) is one of the most important vegetables in the world with a broad-range of pharmacological activities such as antihyperglycemic effect.
Methods In the present study, the cytoprotective effects of aqueous extract of C. moschata fruit on hepatocyte cytotoxicity induced by cumene hydroperoxide (oxidative stress model) or glyoxal (carbonylation model) were investigated using freshly isolated rat hepatocytes.
Results The extract of C. moschata (50 μg/ml) excellently prevented oxidative and carbonyl stress markers, including hepatocyte lysis, ROS production, lipid peroxidation, glutathione depletion, mitochondrial membrane potential collapse, lysosomal damage, and cellular proteolysis. In addition, protein carbonylation was prevented by C. moschata in glyoxal-induced carbonyl stress.
Conclusion It can be concluded that C. moschata has cytoprotective effects in oxidative stress and carbonyl stress models and this valuable vegetable can be considered as a suitable herbal product for the prevention of toxic subsequent of oxidative stress and carbonyl stress seen in chronic hyperglycemia.
Mittel- und langfristige Erfahrungen mit der Boston-Keratoprothese. Die Kölner und Salzburger Perspektive
Authors: Schaub Friederike , Bachmann Björn , Seyeddain Orang , Moussa Sarah , Reitsamer Herbert , Cursiefen Claus 
Published: June 2017

Zusammenfassung
Hintergrund Augen mit schweren kornealen Erkrankungen und unzureichender Prognose für eine Hochrisiko-Hornhauttransplantation können für die Implantation einer Boston-Keratoprothese in Betracht gezogen werden. Seit 2013 wird die Versorgung mit dieser „künstlichen“ Hornhaut an der Kölner Universitätsaugenklinik angeboten, seit 9 Jahren an der Universitätsaugenklinik Salzburg. Mittlerweile konnte in Köln bei 24 Augen, in Salzburg bei 28 Augen eine Boston-Keratoprothese des Typs I (BI-KPro) implantiert werden.
Methoden In diesem Beitrag werden Ergebnisse und Komplikationen nach BI-KPro erörtert, sowohl aus der Literatur in PubMed als auch auf Grundlage der Kölner und Salzburger Erfahrungen.
Ergebnisse 24 Augen von 22 Patienten wurden seit September 2013 in Köln mit einer BI-KPro versorgt, davon konnte bisher nur eine Keratoprothese nicht erhalten werden und ein Visusanstieg wurde in 23 Augen (96%) herbeigeführt. Durchschnittlich waren 1,5 Revisionseingriffe pro Auge im bisherigen postoperativen Verlauf erforderlich. Seit 2007 wurde bei 28 Augen in Salzburg eine BI-KPro implantiert. Es zeigte sich in 62% (16 von 26 Augen) ein postoperativer Visusanstieg, bei einer Komplikationsrate bei einem längeren Follow-up von 81%. In beiden Kohorten reichten die Komplikationen von retroprosthetischer Membranbildung über Sekundärglaukome, infektiöse Keratitiden mit oder ohne Transplantateinschmelzung, Vitritis bis hin zur Endophthalmitis.
Schlussfolgerung Das Spektrum der möglichen Komplikationen nach BI-KPro ist breit, jedoch stellt die BI-KPro die derzeit am häufigsten verwendete Form des künstlichen Hornhautersatzes in Hochrisikoaugen dar und führt bei der Mehrzahl der Patienten zum Visusanstieg.
Adaptive self-organization of Bali’s ancient rice terraces
Authors: Lansing J. Stephen , Thurner Stefan , Chung Ning Ning , Coudurier-Curveur Aurélie , Karakaş Çağil , Fesenmyer Kurt A. , Chew Lock Yue 
Published: June 2017

Significance
In Bali, the cooperative management of rice terraces extends beyond villages to whole watersheds. To understand why, we created a model that explores how cooperation can propagate from pairs of individuals to extended groups, creating a resilient system of bottom-up management that both increases and equalizes harvests. Spatial patterns of collective crop management—observable in Google Earth—closely match the predictions of the model. The spatial patterning that emerges is nonuniform and scale-free. Although the model parameters here are tuned to Bali, similar mechanisms of emergent global control should be detectible in other anthropogenic landscapes using multispectral imagery. Recognizing this signature of emergent system-wide cooperation may help planners to avoid unproductive changes to successful bottom-up systems of environmental management.
Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells
Authors: Genini Davide , Brambilla Lara , Laurini Erik , Merulla Jessica , Civenni Gianluca , Pandit Shusil , D'Antuono Rocco , Perez Laurent , Levy David E. , Pricl Sabrina , Carbone Giuseppina M. , Catapano Carlo V. 
Published: June 2017

Significance
The transcription factor STAT3 is involved in multiple oncogenic signaling pathways and is an attractive therapeutic target. This study shows that a potent inhibitor of STAT3 interferes with mitochondrial activity and protein homeostasis, leading to a synthetic lethality effect in glucose-depleted cancer cells. These findings provide a rationale for novel strategies based on the use of STAT3 inhibitors for cancer treatment.
Stratospheric ozone over the United States in summer linked to observations of convection and temperature via chlorine and bromine catalysis
Authors: Anderson James G. , Weisenstein Debra K. , Bowman Kenneth P. , Homeyer Cameron R. , Smith Jessica B. , Wilmouth David M. , Sayres David S. , Klobas J. Eric , Leroy Stephen S. , Dykema John A. , Wofsy Steven C. 
Published: June 2017

Significance
Stratospheric ozone is one of the most delicate aspects of habitability on the planet. Removal of stratospheric ozone over the polar regions in winter/spring has established the vulnerability of ozone to halogen catalytic cycles. Elevated ClO concentrations engendered, in part, by heterogeneous catalytic conversion of inorganic chlorine to free radical form on ubiquitous sulfate−water aerosols, govern the rate of ozone removal. We report here observations of the frequency and depth of penetration of convectively injected water vapor into the stratosphere, triggered by severe storms that are specific to the central United States in summer, and model their effect on lower stratospheric ozone. This effect implies, with observed temperatures, increased risk of ozone loss over the Great Plains in summer.
Entropy in molecular recognition by proteins
Authors: Caro José A. , Harpole Kyle W. , Kasinath Vignesh , Lim Jackwee , Granja Jeffrey , Valentine Kathleen G. , Sharp Kim A. , Wand A. Joshua 
Published: June 2017

Significance
Molecular recognition by proteins is a key element of biology. Appreciation of the underlying thermodynamics has been incomplete because of uncertainty in several contributions to the entropy. Here, we demonstrate a way to measure changes in protein conformational entropy using a dynamical proxy provided by NMR relaxation methods. We find that conformational entropy can contribute significantly and variably to the thermodynamics of binding. In addition, we determine the contribution of rotational-translational entropy loss upon forming a high-affinity complex involving a protein. The contribution of solvent entropy is also recalibrated. Thus, a more complete view of entropy in binding has been established and shows that inclusion of conformational entropy is necessary to understanding the origins of high-affinity interactions involving proteins.
Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death
Authors: Turriani Elisa , Lázaro Diana F. , Ryazanov Sergey , Leonov Andrei , Giese Armin , Schön Margarete , Schön Michael P. , Griesinger Christian , Outeiro Tiago F. , Arndt-Jovin Donna J. , Becker Dorothea 
Published: June 2017

Significance
People with Parkinson’s disease, the second most common neurodegenerative disorder, have a lower risk and decreased incidence of cancer with the one exception being melanoma. The fact that, compared with other malignancies, melanoma occurs more frequently in patients with Parkinson’s disease and vice versa and that there is an association between a history of melanoma and an increased prevalence of prodromal markers of Parkinson’s disease prompted us to explore the possibility of an inverse biological link between these two diseases. The findings of our study suggest that α-synuclein, one of the key regulators in Parkinson’s disease, although toxic to dopaminergic neurons, is protective for advanced melanoma cells.
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication
Authors: Munke Anna , Persson Jonas , Weiffert Tanja , De Genst Erwin , Meisl Georg , Arosio Paolo , Carnerup Anna , Dobson Christopher M. , Vendruscolo Michele , Knowles Tuomas P. J. , Linse Sara 
Published: June 2017

Significance
The promise of antibody-based strategies to combat Alzheimer’s disease by inhibiting the aggregation of the amyloid β peptide (Aβ) has not yet been realized in clinical trials. In part, this situation has arisen because the antibodies explored so far have been developed without the benefit of the mechanistic information needed to block specific steps in Aβ aggregation. We introduce a strategy to target specifically fibril-dependent secondary nucleation, the microscopic step found to generate most neurotoxic Aβ assemblies. Phage display libraries are screened to find antibodies that bind to Aβ fibrils, followed by affinity ranking and chemical kinetic analysis. Our results suggest that such antibodies may serve as starting points for the development of effective therapeutics for neurodegenerative diseases.
Offspring of parents who were separated and not speaking to one another have reduced resistance to the common cold as adults
Authors: Murphy Michael L. M. , Cohen Sheldon , Janicki-Deverts Denise , Doyle William J. 
Published: June 2017

Significance
Adults whose parents separated during childhood are at increased risk for poorer health, although the underlying mechanisms remain unclear. Furthermore, increasing evidence suggests that aspects of the family environment following parental separation better predict a child’s adjustment than the separation itself. Using a viral challenge study, we found that adults whose parents separated but remained on speaking terms during childhood were no more likely to develop a cold when exposed to a cold-causing virus than adults from intact childhood families. However, adults whose parents separated and did not speak to each other during childhood were more than three times as likely to develop a cold following viral exposure. This increased risk was attributed to heightened inflammation in response to infection.
Language from police body camera footage shows racial disparities in officer respect
Authors: Voigt Rob , Camp Nicholas P. , Prabhakaran Vinodkumar , Hamilton William L. , Hetey Rebecca C. , Griffiths Camilla M. , Jurgens David , Jurafsky Dan , Eberhardt Jennifer L. 
Published: June 2017

Significance
Police officers speak significantly less respectfully to black than to white community members in everyday traffic stops, even after controlling for officer race, infraction severity, stop location, and stop outcome. This paper presents a systematic analysis of officer body-worn camera footage, using computational linguistic techniques to automatically measure the respect level that officers display to community members. This work demonstrates that body camera footage can be used as a rich source of data rather than merely archival evidence, and paves the way for developing powerful language-based tools for studying and potentially improving police–community relations.
Transposon mutagenesis identifies chromatin modifiers cooperating with
Ras
in thyroid tumorigenesis and detects
ATXN7
as a cancer gene
Authors: Montero-Conde Cristina , Leandro-Garcia Luis J. , Chen Xu , Oler Gisele , Ruiz-Llorente Sergio , Ryder Mabel , Landa Iñigo , Sanchez-Vega Francisco , La Konnor , Ghossein Ronald A. , Bajorin Dean F. , Knauf Jeffrey A. , Riordan Jesse D. , Dupuy Adam J. , Fagin James A. 
Published: June 2017

Significance
Mutations of RAS are believed to be early events in thyroid tumorigenesis but are insufficient to induce transformation. A forward genetic screen with transposons engineered to integrate randomly into the mouse Ras-mutant thyroid cell genome and to disrupt genes at their insertion sites resulted in tumors that phenocopied human RAS-driven, poorly differentiated thyroid cancers. Analysis of the transposon-integration sites revealed recurrent mutations of chromatin modifiers and PI3K pathway genes, consistent with mutations seen in human advanced thyroid cancers. These human cancers have a high mutation burden, which confounds distinctions between driver and passenger mutations. This unbiased screen for genes selected during tumorigenesis provides strong functional support for genetic disruptions in these pathways in RAS-induced thyroid tumor progression.
Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID
in Arabidopsis
Authors: Lin Fang , Xu Dongqing , Jiang Yan , Chen Haodong , Fan Liumin , Holm Magnus , Deng Xing Wang 
Published: June 2017

Significance
As an E3 ubiquitin ligase, CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) directly ubiquitinates and triggers the degradation of various downstream targets and acts as a central repressor of light signaling. In this study, our data reveal that a Ser/Thr kinase, PINOID (PID), promotes photomorphogenic development. PID directly interacts with COP1 and phosphorylates it at the site of Ser20, thereby repressing the activity of COP1 in plants. Thus, our findings provide insight into the precise regulatory mechanism in maintaining appropriate COP1 activity in response to dynamically changing light conditions in plants.
Probabilistic model predicts dynamics of vegetation biomass in a desert ecosystem in NW China
Authors: Wang Xin-ping , Schaffer Benjamin Eli , Yang Zhenlei , Rodriguez-Iturbe Ignacio 
Published: June 2017

Significance
The temporal dynamics of vegetation biomass are of vital importance for evaluating the sustainability of arid and semiarid ecosystems. Field observations indicate that soil moisture and plant biomass fluctuate stochastically with the occurrence of rainfall events. Based on long-term field observations, we find that the dynamics of the vegetation biomass can be quantified by their analytically derived time-dependent probability distribution. This allows for the study of the impact of climate change scenarios on vegetation cover and plant water resource competition. It is found that in a restored desert ecosystem in northwest (NW) China, the growing season leaf biomass is expected to increase by nearly 25% compared to the present.
Extended use of demonstrative pronouns in two generations of Mandarin Chinese speakers in the Netherlands
Authors: Aalberse Suzanne , Zou Yiwen , Andringa Sible 
Published: June 2017

Abstract
This study investigated the use of demonstratives in encoding already mentioned referents in two generations of Mandarin Chinese speakers in the Netherlands. Data from twelve families was compared to baseline data from eight native controls in China. Previous literature suggests that languages without dedicated morphology to encode definiteness might develop such morphemes in contact with a language with articles (cf. Backus, Doğruöz, & Heine, 2011). Demonstrative pronouns may be reinterpreted as articles and this process could result in an increase in demonstrative use. We accordingly expected to find such an increase in Mandarin Chinese spoken in the Netherlands and found confirmation for this in both generations of speakers. A preference for the distal demonstrative was observed only in the second generation.
Specificity and validity in the SLA literature
Authors: Le Bruyn Bert , Dong Xiaoli 
Published: June 2017

Abstract
We propose a new paradigm for testing the influence of specificity on the acquisition of English articles (Ionin, 2003; Ionin et al., 2004; Ionin et al., 2009; Ko et al., 2010). We discuss and resolve issues of validation and present a preview and discussion of the results the new paradigm generates for L2 learners of English with Mandarin as an L1.
L2 Acquisition of English article choice by Dutch native speakers
Authors: Schaeffer Jeannette , Horselenberg Chantal , van Koert Margreet 
Published: June 2017

Abstract
Some languages base their article choice on specificity (Samoan), others on definiteness (English: a vs. the). As for L2 article acquisition, Ionin, Zubizaretta, and Maldonado (2008) argue that definiteness-based article choice in the L1 (Spanish) enhances article-acquisition in a definiteness-based L2 (English). However, Deprez, Sleeman, and Guella (2008) show that Dutch learners of L2-French (both definiteness-based) perform poorly on French article choice, suggesting reliance on specificity, and refuting positive L1 influence.
The current study is a pilot investigation into L2-English article choice in 104 native Dutch speakers. The results show definite and indefinite article overuse in the primary, but not in the elementary-intermediate-proficiency groups. We propose that lexical-semantic proficiency is a necessary condition for cross-linguistic influence to be visible.
The L2 acquisition of the French quantitative pronoun en by L1 learners of Dutch
Authors: Sleeman Petra , Ihsane Tabea 
Published: June 2017

Abstract
Success or failure in L2 acquisition has been attributed to different factors, such as the linguistic domain involved, (the absence of) instruction or positive or negative transfer. Whereas in most of the literature these factors are studied separately, in this paper we investigate the relative impact of each of them, analyzing the L2 acquisition of the French quantitative pronoun en by native speakers of Dutch. On the basis of acquisition data elicited in a Grammaticality Judgment Task, we show that the L2 acquisition of en proceeds very slowly. We argue that this is mainly caused by the presence of a similar, but not completely equivalent pronoun in Dutch.