bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simple method to measure CLOCK-BMAL1 DNA binding activity in tissue and cell extracts
Authors: Gillessen Maud , Kwak Pieter Bas , Tamayo Alfred 
Published: August 2017

The proteins CLOCK and BMAL1 form a heterodimeric transcription factor essential to circadian rhythms in mammals. Daily rhythms of CLOCK-BMAL1 DNA binding activity are known to oscillate with target gene expression in vivo. Here we present a highly sensitive assay that recapitulates native CLOCK-BMAL1 DNA binding rhythms from crude tissue extracts, which we call the Clock Protein-DNA Binding Assay (CPDBA). This method can detect less than 2-fold differences in DNA binding activity, and can deliver results in two hours or less using 10 microliters or less of crude extract, while requiring neither specialized equipment nor expensive probes. To demonstrate the sensitivity and versatility of this assay, we show that enzymatic removal of phosphate groups from proteins in tissue extracts or pharmacological inhibition of casein kinase I in cell culture increased CLOCK-BMAL1 DNA binding activity by ~1.5 to ~2 fold, as measured by the CPDBA. In addition, we show that the CPDBA can measure CLOCK-BMAL1 binding to reconstituted chromatin. The CPDBA is a sensitive, fast, efficient and versatile probe of clock function.
Testing: A Systemic Functional View of High Stakes Test Preparation Materials
Authors: Schulze Joshua 
Published: August 2017

Educators of English language learners (ELLs) frequently use test preparation materials to help ELLs prepare for high stakes language exams. This study uses tools of systemic functional linguistics (SFL) to examine how academic language is used to construct meaning within these test preparation materials. While the test preparation materials and available test excerpts contain a range of genres, this study focuses particularly on informational texts with scientific topics, designed for upper elementary students. The results highlight pedagogical advantages of using SFL to develop genre awareness in ELLs by attending to the linguistic features evident in the genre.
Student or Teacher: The Tensions Faced by a Spanish Language Student Teacher
Authors: Vélez Rendón Gloria 
Published: August 2017

The contradictory realities of student teaching viewed through the student teachers’ eyes have been the focus of attention of some recent publications (Britzman, 1991; Knowles and Cole, 1994; Carel, S.; Stuckey, A.; Spalding, A.;Parish, D.; Vidaurri, L; Dahlstrom, K.; and Rand, Ch., 1996; Weber Mitchell, 1996). Student teachers are “marginally situated in two worlds” they are to educate others while being educated themselves (Britzman, 1991, p. 13). Playing the two roles simultaneously is highly difficult. The contradictions, dilemmas, and tensions inherent in such endeavor make the world of the student teacher increasingly problematic. This is further complicated by the power relationships that often permeate the student teacher cooperating teacher relationship. This paper describes salient aspects of the student teaching journey of Sue, a white twenty-two year old student teacher of Spanish. It uncovers the tensions and dilemmas experienced by the participant in her quest for professional identity. Data collection sources for this study included (a) two open-ended interviews, each lasting approximately forty-five minutes; (b) one school-day long observation; and (c) a copy of the communication journal between the participant and her cooperating teacher. The data revealed that soon upon entering the student teaching field experience, Sue found herself torn by the ambiguous role in which student teachers are positioned: she was neither a full-fledged teacher nor a student. In trying to negotiate a teaching role for herself, Sue was pulled in different directions. She soon became aware of the powerful position of the cooperating teacher and of her vulnerability within the mentoring relationship. The main tension was manifested in Sue’s struggle to develop her own teaching persona on the one hand, and the pressure to conform to her cooperating teachers’ expectations on the other hand. The implications of the study are discussed.
Developing Reflective and Investigative Skills in Teacher Preparation Programs: The design and implementation of the Classroom Research Component at the Foreign Language Program of Universidad del Valle
Authors: Cárdenas Ramos Rosalba , Faustino Carmen Cecilia 
Published: August 2017

In this article we want to describe our process and experience in studying, designing, planning and implementing the Classroom Research Component in the first five semesters of the Licenciatura program at the School of Language Science, Universidad del Valle. We want to stress the role of Classroom Research in our students’ initial training and in our own professional development. We also want to show the importance of preparing students and future teachers who possess not only linguistic competence in the foreign languages, but also competences that allow them to reflect, analyze and find ways of improving their professional practice.The description of this experience leads us to share our achievements, difficulties and plans for future development.
A fractional Kirchhoff problem involving a singular term and a critical nonlinearity
Authors: Fiscella Alessio 
Published: August 2017

AbstractIn this paper, we consider the following critical nonlocal problem:\left\{\begin{aligned} &\displaystyle M\bigg{(}\iint_{\mathbb{R}^{2N}}\frac{% \lvert u(x)-u(y)\rvert^{2}}{\lvert x-y\rvert^{N+2s}}\,dx\,dy\biggr{)}(-\Delta)% ^{s}u=\frac{\lambda}{u^{\gamma}}+u^{2^{*}_{s}-1}&&\displaystyle\phantom{}\text% {in }\Omega,\\ \displaystyle u&\displaystyle>0&&\displaystyle\phantom{}\text{in }\Omega,\\ \displaystyle u&\displaystyle=0&&\displaystyle\phantom{}\text{in }\mathbb{R}^{% N}\setminus\Omega,\end{aligned}\right.where Ω is an open bounded subset of{\mathbb{R}^{N}}with continuous boundary, dimension{N>2s}with parameter{s\in(0,1)},{2^{*}_{s}=2N/(N-2s)}is the fractional critical Sobolev exponent,{\lambda>0}is a real parameter,{\gamma\in(0,1)}andMmodels a Kirchhoff-type coefficient, while{(-\Delta)^{s}}is the fractional Laplace operator. In particular, we cover the delicate degenerate case, that is, when the Kirchhoff functionMis zero at zero. By combining variational methods with an appropriate truncation argument, we provide the existence of two solutions.
Existence and Asymptotic Behavior of Positive Solutions for a Class of Quasilinear Schrödinger Equations
Authors: Wang Youjun , Shen Yaotian 
Published: August 2017

Abstract
In this paper, we study the quasilinear Schrödinger equation

-

Δ
⁢
u

+

V
⁢

(
x
)

⁢
u

-

γ
2

⁢

(

Δ
⁢

u
2

)

⁢
u

=

|
u
|

p
-
2

⁢
u

{-\Delta u+V(x)u-\frac{\gamma}{2}(\Delta u^{2})u=|u|^{p-2}u}

,

x
∈

ℝ
N

{x\in\mathbb{R}^{N}}

, where

V
⁢

(
x
)

:

ℝ
N

→
ℝ

{V(x):\mathbb{R}^{N}\to\mathbb{R}}

is a given potential,

γ
>
0

{\gamma>0}

, and either

p
∈

(
2
,

2
*

)

{p\in(2,2^{*})}

,

2
*

=

2
⁢
N

N
-
2

{2^{*}=\frac{2N}{N-2}}

for

N
≥
4

{N\geq 4}

or

p
∈

(
2
,
4
)

{p\in(2,4)}

for

N
=
3

{N=3}

. If

γ
∈

(
0
,

γ
0

)

{\gamma\in(0,\gamma_{0})}

for some

γ
0

>
0

{\gamma_{0}>0}

, we establish the existence of a positive solution

u
γ

{u_{\gamma}}

satisfying

max

x
∈

ℝ
N

⁡

|

γ
μ

⁢

u
γ

⁢

(
x
)

|

→
0

{\max_{x\in\mathbb{R}^{N}}|\gamma^{\mu}u_{\gamma}(x)|\to 0}

as

γ
→

0
+

{\gamma\to 0^{+}}

for any

μ
>

1
2

{\mu>\frac{1}{2}}

. Particularly, if

V
⁢

(
x
)

=
λ
>
0

{V(x)=\lambda>0}

, we prove the existence of a positive classical radial solution

u
γ

{u_{\gamma}}

and up to a subsequence,

u
γ

→

u
0

{u_{\gamma}\to u_{0}}

in

H
2

⁢

(

ℝ
N

)

∩

C
2

⁢

(

ℝ
N

)

{H^{2}(\mathbb{R}^{N})\cap C^{2}(\mathbb{R}^{N})}

as

γ
→

0
+

{\gamma\to 0^{+}}

, where

u
0

{u_{0}}

is the ground state of the problem

-

Δ
⁢
u

+

λ
⁢
u

=

|
u
|

p
-
2

⁢
u

{-\Delta u+\lambda u=|u|^{p-2}u}

,

x
∈

ℝ
N

{x\in\mathbb{R}^{N}}

.
A method to predict fatigue crack initiation in metals using dislocation dynamics
Authors: Heinrich Christian , Sundararaghavan Veera 
Published: August 2017

AbstractA theory is proposed to predict the initiation of fatigue cracks using cyclic dislocation dynamics (DD) simulations. The evolution of dislocation networks in a grain is simulated over several cycles. It is shown that the dislocation density and the energy stored in the dislocation networks increase with the number of cycles. The results of the DD simulations are used to construct an energy balance expression for crack initiation. A hypothetical crack is inserted into the grain, and the Gibbs energy consisting of the energy of the dislocation structure, the surface energy of the hypothetical crack, and the reduction in continuum energy is evaluated. Once the Gibbs energy attains a maximum, the dislocation structure becomes unstable, and it becomes energetically more favorable to form a real crack. The proposed method is applied to oxygen-free high conductivity copper, and the results are compared against experiments. Finally, it is shown how the method can be amended to account for environmental effects.
The effect of tunable morphology on the potential application of p(acrylic acid-co-2-ethylhexyl acrylate)/silica nanohybrids
Authors: Nazarabady Maryam Mohammadpour , Farzi Gholamali 
Published: August 2017

AbstractThe present study deals with the one-pot synthesis of acrylate copolymers/silica latexes through the use of simultaneous radical polymerization of acrylic monomers and a silica sol-gel precursor. In presence of 3-methacryloxypropyltrimethoxysilane (γ-MPS) and 3-aminopropyltriethoxysilane (APTS), compatibility of acrylate chains to the silica species was improved by the chemical bonds as revealed by Fourier transform infrared spectroscopy (FTIR) analysis. Transmission electron microscopy (TEM) demonstrated the successful formation of p(acrylic acid-co-2-ethylhexyl acrylate)/silica nanohybrids with core-shell morphology. The nanohybrids have been used to modify a glassy carbon electrode (GCE). Cyclic voltammetry and electrochemical impedance spectra were utilized to investigate the properties of the modified electrode in a 1.0mKCl solution that contained 1.0 mmK4[Fe(CN)6]/K3[Fe(CN)6], and the interface properties of electrode surfaces. The result showed a dramatic decrease in redox activity as compared to the bare GCE electrode. This revealed a slight increase in electron transfer resistance and the conductivity of the copolymer oligomers and silica species in the hybrid nanostructure. All the electrochemical results illustrated that the p(acrylic acid-co- 2-ethylhexyl acrylate)/silica nanohybrids could immobilize the selective analytes on the electrodes, which had electrochemical catalytic activity. The barrier properties of the hybrid films were also examined via ultraviolet (UV) absorption capacity of the films. It could be concluded that the adsorption capacity was a function of the silica content and uniform dispersion of the nanoparticles in the resultant films.
Zur politischen Funktion der Volksversammlung in Sparta
Authors: Grote Oliver 
Published: August 2017

Zusammenfassung
Untersuchungen der überlieferten Entscheidungen und Debatten in der spartanischen Volksversammlung ergeben, dass diese den politischen Eliten dazu diente, Konsensaussichten für vorgelegte Beschlussanträge abschätzen zu können. Auf diesem Wege und in Verbindung mit der Möglichkeit, es durch rechtzeitige Auflösung der Versammlung gar nicht erst zur Abstimmung kommen zu lassen, wurden die politischen Eliten in die Lage versetzt, unliebsame oder konfliktträchtige Entscheidungen zu verhindern. Wurde eine Abstimmung in der Volksversammlung aber einmal auf den Weg gebracht, so übernahm der Damos die Rolle der ‚Dritten Instanz‘ im Sinne Georg Simmels: Durch die in der Versammlung angenommenen und durch das kratos des Volkes legitimierten Beschlüsse konnte der für Spartas Gesellschaft konstitutive und daher stets vorausgesetzte Konsens angemessen dargestellt werden. Hierin ähnelt das spartanische System dem der römischen Republik: Beide Systeme vermieden die Herstellung politischer Gleichheit ihrer Bürger und ergebnisoffene Verfahren, waren in hohem Maße konsensorientiert und daher auf Regulative des öffentlichen Diskurses angewiesen, um den Konsens beziehungsweise dessen Fiktion aufrechtzuerhalten.
Händler als Helden. Funktionen des Unternehmertums in der Neuzeit
Authors: Eckert Georg 
Published: August 2017

Zusammenfassung
Die heutige Omnipräsenz des Unternehmertums resultiert nicht allein aus dessen wandelhaften ökonomischen Funktionen. Als Quellenbegriff erst seit dem 19. Jahrhundert umfassend belegt, ist Unternehmertum in der Neuzeit vielmehr zu einem integrativen gesellschaftlichen Ideal erwachsen. Der Unternehmer geriet zum Archetyp der westlichen Moderne, die ihm attestierten Eigenschaften erhielten geradezu den Status anthropologischer Zuschreibungen. Diese Entwicklung lässt sich seit dem 17. Jahrhundert nachvollziehen, in dem sich einzelne Händler als Helden zu profilieren wussten – indes so unternehmerisch-risikofreudig bisweilen gar nicht agierten, wie sie vorgaben, während Adelige sich vielfach unternehmerischer Praktiken bedienten, ohne sie so zu benennen. Das 18. Jahrhundert wertete Wissenschaft höher als Mut und pries den sorgfältigen Buchhalter als Inbegriff eines Unternehmertums, das im 19. Jahrhundert als Prinzip Hoffnung nunmehr auch begabten Arbeitern die materielle wie ideelle Selbstverwirklichung verhieß. Die enorme mediale Präsenz des Unternehmers im 20. Jahrhundert schließlich war eng an die Erwartung gebunden, er habe sich als Tatmensch zu beweisen: integrativer Gestus durch Mitarbeiterführung überstrahlte hier das konkrete Geschäftsmodell. Gerade als Fiktion hat das Unternehmertum die moderne Welt mitgeformt; ein ursprüngliches Minderheiten-Konzept konnte für die Mehrheit verbindlich werden, weil es keine Verlierer mehr kannte. Weil die vielleicht wichtigste Funktion des Unternehmers in dessen jeweiliger Inszenierung bestand, wirft dieser Beitrag insbesondere Schlaglichter auf unternehmerische Selbstzuschreibungen, auf publizistische und belletristische Fremdzuschreibungen sowie auf die wirtschaftswissenschaftliche Theoriebildung.
Frequency and risk factors of depression in type 1 diabetes in a developing country
Authors: Khater Doaa , Omar Magdy 
Published: August 2017

AbstractBackground:Living with type 1 diabetes, especially in developing countries, can feel overwhelming for parents and children because constant vigilance is required for proper care with an inadequacy of resources. Our aim was to investigate the frequency and risk factors of depressive symptoms in children and adolescents with type 1 diabetes.Methods:The study was conducted using epidemiologic studies Depression Scale Questionnaire for Children (CES-DC) on 86 patients with type 1 diabetes from the Diabetes Clinic in Alexandria University Children’s Hospital, Egypt. Logistic regression models were used to detect the predictors of depression.Results:In the current study 45 children (52.3%) had scores ≥15 indicating a depressive state. Children who had depression were found to have a significantly longer duration of diabetes (5.84±2.53 year), a higher mean total daily insulin dose (1.36±0.45 unit/kg), HbAConclusions:Children and adolescents with type 1 diabetes have high frequency of depressive symptoms in a developing country. Poor glycemic control is the most significant predictor for depression in these patients.
Carotid intima media thickness in a girl with sitosterolemia carrying a homozygous mutation in the ABCG5 gene
Authors: Yagasaki Hideaki , Nakane Takaya , Toda Takako , Kobayashi Kisho , Aoyama Kouki , Ichikawa Takeshi , Sugita Kanji 
Published: August 2017

AbstractBackground:Sitosterolemia is a rare lipid metabolism disorder that involves storage of plant sterols. This disease is associated with atherosclerosis, but detailed vascular endothelial assessment is difficult.Case presentation:We report a 5-year-old girl with sitosterolemia who presented with xanthomas at 23 months of age. Her total cholesterol was 868 mg/dL, and her plasma sitosterol level was 9.48 mg/dL. Direct sequencing detected a homozygous mutation in geneConclusions:Sitosterolemia is a unique disorder in which it is difficult to avoid premature atherosclerosis because of high sitosterol levels. cIMT measurement with arterial wall assessment may improve management.
Association between urinary phthalates and metabolic abnormalities in obese Thai children and adolescents
Authors: Saengkaew Tansit , Jantarat Chutima , Nosoognoen Wichit , Supornsilchai Vichit 
Published: August 2017

AbstractBackground:Several endocrine disruptors (including phthalates) are considered to be a cause of obesity. However, the current evidence has not conclusively established an association between phthalates and metabolic abnormalities, especially in children. The objective of the study was to evaluate the association between urinary phthalate metabolites and metabolic abnormalities in obese Thai children and adolescents.Methods:This cross-sectional case-control study was conducted in participants aged 7–18 years and divided into two groups: normal weight and overweight/obesity. Spot urine concentrations of two phthalate metabolites (monomethyl phthalate [MMP] and mono-n-buthyl phthalate [MBP]) were measured by high performance liquid chromatography (HPLC). Anthropometric data, including weight, height, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHTR), were measured and calculated. Fasting plasma glucose, insulin, HbAResults:One hundred and fifty-five participants were included. The median MMP level in the normal weight and the overweight/obesity groups were 0 (0, 459.83) and 0 (0, 1623.50) μg/g Cr, respectively (p=0.933). The median MBP level in the normal weight and the overweight/obesity groups were 233.6 (118.1, 633.62) and 206.94 (7.4, 427.7) μg/g Cr, respectively (p=0.083). After adjusting for age, gender and puberty, there was no correlation between MBP and all anthropometric data and metabolic profiles. Participants with hypertriglyceridemia had lower MBP levels than those with normal TG level. MMP levels were not significantly different between the participants with normal and abnormal weight of all metabolic parameters.Conclusions:Participants with hypertriglyceridemia had lower MBP levels than those with normotriglyceridemia. However, it cannot show the correlation between phthalate and metabolic parameters.
Teaching from selfhood: A personal growth journey with unimaginable dividends
Authors: Tsikata Prosper Yao 
Published: August 2017

Abstract
In this essay, I reflexively narrate my personal travails as a Teaching Associate (TA) in a Midwestern US university and, later, an Assistant Professor in the Southern State of Georgia. I argue that, as a foreign-born TA and, later, an Assistant Professor, I carry extra layers of identity markers that distinguish me from the homegrown professor. Thus, the masked and the overt demands by the hegemonic institutional forces for conformity to the Anglo-American speech forms and narratives suppress those unique identity markers. So as not to create tension and friction in the classroom, it is challenging not to be seduced to veil those unique identity markers in the cross-cultural intersections of pedagogy. However, unlike the homegrown professor on familiar terrains, by concealing those unique identity markers about myself, my true self is veiled from students and I become a mystery to them in the ensuing pedagogical encounter. With this understanding, I have always positioned my true self as rhetorical act of anchoring that demystifies the strange and invites the native to the never-ending dialogue of discovery.
Isometric Midthigh Pull Performance Is Associated With Athletic Performance and Sprinting Kinetics in Division I Men and Women's Basketball Players
Authors: Townsend Jeremy R. , Bender David , Vantrease William C. , Hudy John , Huet Kevin , Williamson Cassie , Bechke Emily , Serafini Paul R. , Mangine Gerald T. 
Published: August 2017

Abstract
Townsend, JR, Bender, D, Vantrease, WC, Hudy, J, Huet, K, Williamson, C, Bechke, E, Serafini, PR, and Mangine, GT. Isometric midthigh pull performance is associated with athletic performance and sprinting kinetics in Division I men and women's basketball players. J Strength Cond Res 33(10): 2665–2673, 2019— The relationships between isometric mid-thigh pull (IMTP) force, athletic performance measures, and sprint kinetics in Division I men's and women's basketball players were investigated. Twenty-three (male = 8, female = 15) Division 1 basketball players completed a maximal 20-m sprint trial while tethered to a device that provided kinetic feedback (peak and average sprinting power, velocity and force). Additionally, 1 repetition maximum (1RM) front squat, 1RM hang clean, vertical jump height, and agility (proagility and lane agility) tests were performed. Rate of force development (RFD) at 50, 100, 150, 200 and 250 milliseconds of IMTP and peak force (PF) were also collected. Pearson’s product-moment correlation analysis was used to examine the relationships between these measures. Significant (p ≤ 0.05) relationships were observed between IMTP PF and sprint time over all distances (5–20 m; r = −0.62 to 0.69), average sprint velocity (r = 0.50–0.70), peak sprint velocity (r = 0.50–0.54), average sprint force (r = 0.48–0.69), and average sprint power (r = 0.62–0.73). Sprinting kinetic measures (average force and power) over the first 5 m were also significantly (p ≤ 0.05) related to IMTP RFD (50–250 ms; r = 0.42–0.62). Results indicate that IMTP variables are significantly associated with 20-m sprint kinetics. Specifically, IMTP RFD appears to be related to the initial acceleration kinetics of a sprint. Strength and conditioning professionals can possibly implement the IMTP for improved assessment and monitoring of athletic performance and training.
Effects of an Experimental vs. Traditional Military Training Program on 2-Mile Run Performance During the Army Physical Fitness Test
Authors: Stone Brandon L. , Heishman Aaron D. , Campbell Jay A. 
Published: August 2017

Abstract
Stone, BL, Heishman, AD, and Campbell, JA. The effects of an experimental vs. traditional military training program on 2-mile run performance during the army physical fitness test. J Strength Cond Res 34(12): 3431–3438, 2020—The purpose of this study was to compare the effects of an experimental vs. traditional military run training on 2-mile run ability in the Army Reserve Officers' Training Corps cadets. Fifty college-aged cadets were randomly placed into 2 groups and trained for 4 weeks with either an experimental running program (EXP, n = 22) comprised rating of perceived exertion (RPE) intensity-specific, energy system–based intervals or with traditional military running program (TRA, n = 28) using a crossover study design. A 2-mile run assessment was performed just before the start, at the end of the first 4 weeks, and again after the second 4 weeks of training after crossover. The EXP program significantly decreased 2-mile run times (961.3 ± 155.8 seconds to 943.4 ± 140.2 seconds, p = 0.012, baseline to post 1), whereas the TRA group experienced a significant increase in run times (901.0 ± 79.2 vs. 913.9 ± 82.9 seconds) over the same training period. There was a moderate effect size (d = 0.61, p = 0.07) for the experimental run program to “reverse” the adverse effects of the traditional program within the 4-week training period (post 1 to post 2) after treatment crossover. Thus, for short-term training of military personnel, RPE intensity-specific running program comprising aerobic and anaerobic system development can enhance 2-mile run performance superior to a traditional program while reducing training volume (60 minutes per session vs. 43.2 minutes per session, respectively). Future research should extend the training period to determine efficacy of this training approach for long-term improvement of aerobic capacity and possible reduction of musculoskeletal injury.