bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beta-Hydroxybutyrate: A Supplemental Molecule for Various Diseases
Authors: Shahtaghi Navid Reza , Soni Bindu , Bakrey Hossamaldeen , Bigdelitabar Samira , Jain Subheet Kumar 
Published: September 2024

:
β-hydroxybutyrate (BHB) is a ketone body that serves as an alternative energy source
for various tissues, including the brain, heart, and skeletal muscle. As a metabolic intermediate
and signaling molecule, BHB plays a crucial role in modulating cellular and physiological processes.
Notably, BHB supplementation offers a novel and promising strategy to induce nutritional ketosis
without the need for strict dietary adherence or causing nutritional deficiencies. This review article
provides an overview of BHB metabolism and explores its applications in age-related diseases.
This review conducted a comprehensive search of PubMed, ScienceDirect, and other relevant
English-language articles. The main findings were synthesized, and discussed the challenges, limitations,
and future directions of BHB supplementation. BHB supplementation holds potential benefits
for various diseases and conditions, including neurodegenerative disorders, cardiovascular diseases,
cancers, and inflammation. BHB acts through multiple mechanisms, including interactions
with cell surface receptors, intracellular enzymes, transcription factors, signaling molecules, and
epigenetic modifications. Despite its promise, BHB supplementation faces several challenges,
such as determining the optimal dosage, ensuring long-term safety, identifying the most effective
type and formulation, establishing biomarkers of response, and conducting cost-effectiveness analyses.
BHB supplementation opens exciting avenues for research, including investigating molecular
mechanisms, refining optimization strategies, exploring innovation opportunities, and assessing
healthspan and lifespan benefits. BHB supplementation represents a new frontier in health research,
offering a potential pathway to enhance well-being and extend lifespan.
Development of Quality Standard and a Comprehensive Quality Control Study of Bharngyadi Kvatha Churna: An Ayurvedic Formulation
Authors: Narasimhaji Cheemalapati Venkata , Kurra Siva Durga , Bolleddu Rajesh , Marimuthhu Gokul , Dighe Dattatray , Ghandi Yashika , Kumar Vijay , Ghosh Debomitha , Das Manosi , Rao Meda M. , Das Debajyoti , Singh Ravindra , Babu Gajji , Srikanth Narayanam , Acharya Rabinarayan 
Published: September 2024

Background:
Bharngyadi Kvatha Churna (BKC) is an important polyherbal formulation
mentioned in the Ayurvedic Formulary of India (AFI) for the treatment of intermittent fever
and chronic fever but lacks the presence of standardised quality control parameters.

Aims:
The aim of the present study was to develop a quality standard of BKC and to carry out a
comprehensive quality control study, including the evaluation of physicochemical parameters,
safety parameters, elemental content, secondary metabolites, and selected phytochemical analysis.

Methods:
In HPTLC analysis, piperlongumine was quantified in BKC using a silica gel-coated
aluminium plate and developing solvent of toluene: acetone (6:4 v/v). In HPLC analysis, piperine
was quantified using acetonitrile: water (80: 20 v/v) mobile phase, and ellagic acid was quantified
using water (0.05% KH2PO4): acetonitrile (70: 30 v/v) mobile phase. ICP-OES was used to determine
elemental content. The estimation of secondary metabolites like total sugars, tannins,
flavonoids, alkaloids, and saponins was also carried out using a UV-Vis spectrophotometer. The
volatiles present in the volatile oil of BKC were analysed using the gas chromatography-mass
spectrometry technique.

Results:
The physicochemical parameters namely, loss on drying, total ash, acid-insoluble ash, alcohol-
soluble extractive, water-soluble extractive, pH (10% aq. susp.), and volatile oil ranged
from 10.56% to 11.06%, 4.67% to 5.76%, 0.73% to 1.78%, 7.56% to 8.2%, 12.04% to 13.06%,
5.87% to 5.96%, and 0.091% to 0.097%, respectively. The amount of piperlongumine in BKC
ranged from 0.7688 mg/g to 0.9902 mg/g. The amount of piperine and ellagic acid ranged from
0.1180% to 0.1362% and 0.0016% to 0.0034%, respectively. Oleyl alcohol is the major volatile
phytochemical present in BKC.

Conclusions:
The developed standardised quality control parameters of BKC would aid the herbal
industry in developing BKC with requisite quality.
Potential Probiotic Yeasts Isolated from Idli and Selroti, Indian Ethnic Fermented Cereal-based Foods
Authors: Rai Aakriti , Lama Sonam , Das Souvik , Thatal Bipashna , Tamang Jyoti Prakash 
Published: September 2024

Introduction:
In the present study, we focused on the screening of the potential probiotic
yeasts isolated from two Indian fermented cereal-based foods, viz., idli and selroti. A total of 260
yeast isolates were isolated from the batters of idli (140 isolates) and selroti (120 isolates).

Methods:
Preliminary screening of basic probiotic traits such as tolerance to low pH, bile, and cell
surface attachment was checked for the selection of potential probiotic yeasts from total isolates.
Finally, 8 yeast isolates were selected for further in-depth assessment by in vitro and genetic screening,
which included Clavispora lusitaniae AIY-4, Wickerhamomyces anomalus MIY-30, Pichia
kudriavzevii BIY-8 (from idli), Yarrowia lipolytica SGLY-15, Y. lipolytica SGLY-21, Candida parapsilosis
SPRY-17, C. parapsilosis SBRY-12, and Kodamaea ohmeri SBRY-25 (from selroti).

Results:
A principal component analysis (PCA) biplot was designed to evaluate the differences and
similarities amongst the yeast strains, and two clusters were formed using the paired group (UPGMA)
algorithm and Euclidean similarity index. Cluster one was comprised of Cl. lusitaniae AIY-
4, W. anomalus MIY-30, C. parapsilosis SBRY-12, and P. kudriavzevii BIY-8, and another cluster
included C. parapsilosis SBRY-12 and Y. lipolytica SGLY-21.

Conclusion:
Hence, based on statistical analysis for probiotic in vitro and genetic screening, Wickerhamomyces
anomalus MIY-30 (idli) and Kodamaea ohmeri SBRY-25 (selroti) were selected as
the most potential probiotic strains.
Pengaruh Kualitas Produk Dan Periklanan Terhadap Minat Pembelian Ulang
Authors: Meirinta Larissa Apsarini , Isharina Ikhtiara Kaideni 
Published: September 2024

Viva Cosmetics is one of the popular local cosmetic brands in Indonesia, Under PT Vitapharm, the products started to be marketed in 1962. Since 2021, the market share of the company has decreased, and this condition is not the company’s vision. Therefore, it needs strategies to increase the number of consumers, one of them is by enhancing their repurchase intention. The objective of this research is to identify the effects of product quality and advertisement on the repurchase intention of Viva Cosmetics’ consumers in Java. This quantitative explanatory research elucidates the causal relationship between its variables through hypothesis testing. From the infinite population of all Viva Cosmetics Consumers in Java, 140 females with the minimum age of eighteen years who live in Java and have at least made one purchase of the brand’s product since 2022 were selected as the sample through non-probability sampling method. This study uses multiple linear regression analysis. The results indicate that product quality positively and significantly influences the repurchasing intention of people in Java and that advertisement has no significant effect on the said intention.

Abstrak
Viva Cosmetics merupakan salah satu merek produk kecantikan lokal ternama di Indonesia yang sudah berdiri sejak 1962 oleh PT Vitapharm. Berdasarkan data survei, merek ini mengalami penurunan pangsa pasar sejak 2021 sampai sekarang yang tidak sesuai dengan visinya. Oleh karena itu dibutuhkan strategi untuk meningkatkan konsumen dan salah satunya dengan melakukan analisis minat pembelian ulang. Penelitian ini bertujuan untuk mengetahui pengaruh kualitas produk dan periklanan terhadap minat pembelian ulang produk Viva Cosmetics di Pulau Jawa. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksplanatori, yaitu menjelaskan hubungan kausal antara variabel melalui pengujian hipotesis. Populasi penelitian ini adalah seluruh konsumen Viva Cosmetics di Pulau Jawa dengan jumlah infinit. Teknik pengambilan sampel yang digunakan adalah non-probabilitas sebanyak 140 sampel dari populasi yang ada, dengan sampel wanita berusia minimal delapan belas tahun yang berdomisili di Pulau Jawa dan pernah membeli produk Viva Cosmetics minimal satu kali sejak tahun 2022. Penelitian ini menggunakan analisis regresi linier berganda. Berdasarkan hasil penelitian yang dilakukan, dapat disimpulkan bahwa kualitas produk memiliki pengaruh positif signifikan sedangkan periklanan tidak berpengaruh signifikan terhadap minat pembelian ulang produk Viva Cosmetics di Pulau Jawa.
An Evidence-Based Nurse-Led Intervention to Reduce Diabetes Distress Among Adults With Type 1 Diabetes and Diabetes Distress (REDUCE): Development of a Complex Intervention Using Qualitative Methods Informed by the Medical Research Council Framework
Authors: Stenov Vibeke , Cleal Bryan , Willaing Ingrid , Christensen Jette Normann , Jensen Christian Gaden , Mouritsen Julie Drotner , Due-Christensen Mette 
Published: September 2024

Background
Diabetes distress refers to the negative emotional reaction to living with the demands of diabetes; it occurs in >40% of adults with type 1 diabetes (T1D). However, no interventions to reduce diabetes distress are specifically designed to be an integral part of diabetes care.

Objective
This study aims to modify and adapt existing evidence-based methods into a nurse-led group intervention to reduce diabetes distress among adults with T1D and moderate to severe diabetes distress.

Methods
The overall framework of this study was informed by the initial phase of the Medical Research Council’s complex intervention framework that focused on undertaking intervention identification and development to guide the adaptation of the intervention. This study took place at 2 specialized diabetes centers in Denmark from November 2019 to June 2021. A total of 36 adults with T1D participated in 10 parallel workshops. A total of 12 diabetes-specialized nurses were interviewed and participated in 1 cocreation workshop; 12 multidisciplinary specialists, including psychologists, educational specialists, and researchers, participated in 4 cocreation workshops and 14 feedback meetings. Data were analyzed by applying a deductive analytic approach.

Results
The intervention included 5 biweekly 2.5-hour small group sessions involving adults with T1D and diabetes distress. Guided by a detailed step-by-step manual, the intervention was delivered by 2 trained diabetes specialist nurses. The intervention material included visual conversation tools covering seven diabetes-specific sources derived from the 28-item Type 1 Diabetes Distress Scale for measuring diabetes distress: (1) powerlessness, (2) self-management, (3) fear of hypoglycemia, (4) food and eating, (5) friends and family, (6) negative social perception, and (7) physician distress. The tools are designed to kick-start awareness and sharing of diabetes-specific challenges and strengths, individual reflections, as well as plenary and peer-to-peer discussions about strategies to manage diabetes distress, providing new perspectives on diabetes worries and strategies to overcome negative emotions. Diabetes specialist nurses expressed a need for a manual with descriptions of methods and detailed guidelines for using the tools. To deliver the intervention, nurses need increased knowledge about diabetes distress, how to support diabetes distress reduction, and training and supervision to improve skills.

Conclusions
This co-design study describes the adaptation of a complex intervention with a strong evidence base, including detailed reporting of the theoretical underpinnings and core mechanisms.
Development Trends and Prospects of Technology-Based Solutions for Health Challenges in Aging Over the Past 25 Years: Bibliometric Analysis
Authors: Liu Lu , Wang Xiu-Ling , Cheng Nuo , Yu Fu-Min , Li Hui-Jun , Mu Yang , Yuan Yonghui , Dong Jia-Xin , Wu Yu-Dan , Gong Da-Xin , Wang Shuang , Zhang Guang-Wei 
Published: September 2024

Background
As the global population ages, we witness a broad scientific and technological revolution tailored to meet the health challenges of older adults. Over the past 25 years, technological innovations, ranging from advanced medical devices to user-friendly mobile apps, are transforming the way we address these challenges, offering new avenues to enhance the quality of life and well-being of the aging demographic.

Objective
This study aimed to systematically review the development trends in technology for managing and caring for the health of older adults over the past 25 years and to project future development prospects.

Methods
We conducted a comprehensive bibliometric analysis of literatures related to technology-based solutions for health challenges in aging, published up to March 18, 2024. The search was performed using the Web of Science Core Collection, covering a span from 1999 to 2024. Our search strategy was designed to capture a broad spectrum of terms associated with aging, health challenges specific to older adults, and technological interventions.

Results
A total of 1133 publications were found in the Web of Science Core Collection. The publication trend over these 25 years showed a gradual but fluctuating increase. The United States was the most productive country and participated in international collaboration most frequently. The predominant keywords identified through this analysis included “dementia,” “telemedicine,” “older-adults,” “telehealth,” and “care.” The keywords with citation bursts included “telemedicine” and “digital health.”

Conclusions
The scientific and technological revolution has significantly improved older adult health management, particularly in chronic disease monitoring, mobility, and social connectivity. The momentum for innovation continues to build, with future research likely to focus on predictive analytics and personalized health care solutions, further enhancing older adults’ independence and quality of life.
Xác định ngưỡng chịu mặn của cừu (Ovis aries) Phan Rang khi cho uống nước biển pha loãng
Authors: Nguyễn Thiết , Nguyễn Thanh Đạt , Nguyễn Trọng Ngữ 
Published: September 2024

Thí nghiệm nhằm đánh giá ngưỡng chịu mặn của cừu (Ovis aries) và được thực hiện trên 10 cừu đực, chia thành 2 giai đoạn. Giai đoạn 1 cho cừu uống nước ngọt trong 7 ngày từ hai máng uống giống nhau. Giai đoạn 2 trong 8 ngày cho cừu uống nước ngọt cho máng uống thứ nhất và nước biển pha loãng (DSW) cho máng uống thứ hai hoặc ngược lại, nồng độ DSW (diluted seawater) từ 0,5% đến 2,0%. Kết quả cho thấy khối lượng cơ thể và lượng chất khô ăn vào không khác nhau bởi DSW, trong khi lượng nước uống vào cao hơn ở giai đoạn 2 (P<0,05). Cừu uống nhiều DSW ở nồng độ 0,5% và sau đó giảm sự lựa chọn DSW ở nồng độ 1,0%, tránh lựa chọn DSW ở nồng độ 1,5% và từ chối uống ở nồng độ 2,0%. Cừu uống DSW tăng nồng độ natri và clorua huyết tương, trong khi đó kali huyết tương không khác nhau giữa giai đoạn 1 và 2. Nồng độ urê, creatine, AST và ALT huyết tương không thay đổi giữa hai giai đoạn. Kết quả thí nghiệm cho rằng cừu có thể chịu đựng được DSW lên tới 1%.
The patent rights of pharmaceutical products and death: between economic balance and human rights
Authors: Suryahartati Dwi , Windarto Windarto , Nuriyatman Eko , Kadir Nor Aida binti Ab 
Published: September 2024

This study further highlights the relevancy between patent rights and human rights. The impact of the availability and accessibility of essential medicines necessary for Public Health is significant. This study primarily aims to analyze and examine the relationship of patent rights on medicines and pharmaceutical products with human rights and to criticize and evaluate whether the Indonesian government has a policy configuration in the field of essential drugs and the pharmaceutical industry following the principles that support human rights. This research employed qualitative and normative-juridical methods supported by conceptual, statutory, and legal political approaches. Using the theories of legal objectives, utility, and justice, this research focuses on understanding economic law and human rights. Through in-depth analysis, this study highlights how the patent system for drugs and pharmaceutical products encourages innovation and faces criticism due to limited access for economically vulnerable groups. Hence, the right to health is hampered while the state is responsible for universal access to affordable health care. The findings of the study indicate that the Patent Rights on drugs and pharmaceutical products are exclusive rights that intersect with human rights in the drug patent system. Several parameters can be used to examine the relationship between human rights and intellectual property. It is necessary to reform the drug patent system to protect the balance and human rights. The findings contribute to a complex understanding of the relevance of patents to human rights while providing a basis for inclusive and sustainable policy development in the global health domain.
PENGARUH GREEN MARKETING, GREEN IMAGE & SUSTAINABLE BEAUTY AWARENESS TERHADAP GREEN PURCHASE INTENTION PADA LOVE BEAUTY AND PLANET DI JAKARTA
Authors: Kristanti Lisa , Ramli Yanto 
Published: September 2024

ABSTRAKPenelitian ini bertujuan untuk menganalisis dan menjelaskan pengaruh Green Marketing, Green Image & Sustainable Beauty Awareness terhadap Purchase Intention pada Love Beauty and Planet di Jakarta. Jenis penelitian yang digunakan dalam penelitian ini adalah kuantitatif dan metode penelitian yang digunakan adalah metode analisis kausal. Sampel yang digunakan adalah sebanyak 150 responden. Metode pengambilan sampel menggunakan purposive sampling. Metode analisis data menggunakan Partial Least Square (PLS) dengan Teknik analisis yang digunakan adalah deskriptif. Hasil penelitian membuktikan bahwa semua variabel berpengaruh positif dan siginifikan terhadap Purchase Intention. Ini berarti bahwa Love Beauty and Planet merupakan pelopor untuk produk perawatan kulit yang alami dan sehat di dunia dan mempratikan konsep ramah lingkungan pada setiap produknya. Kata kunci: Green Marketing, Green Image, Sustainable Beauty Awareness, dan Purchase Intention.
Linguagens visuais e cultura: entrevista com o Prof. Edson Dias Ferreira sobre a importância cultural e legado acadêmico e social do LabImagem na Universidade Estadual de Feira de Santana.
Authors: Da Silva Bomfim Jacson , Dias Ferreira Edson 
Published: September 2024

A entrevista descrita neste texto foi realizada com o professor doutor Edson Dias Ferreira, da Universidade Estadual de Feira de Santana (UEFS) na Bahia. O roteiro foi previamente enviado e após verificadas as possibilidades de realização, agendamos a data da entrevista pela Plataforma do Google Meet. A presente sugestão de leitura, tem por objetivo, compor reflexões acerca dos temas linguagens visuais e cultura na perspectiva do Professor Edson, e como elas tiveram influência na sua vida acadêmica como um todo, ressaltando a importância das linguagens audiovisuais e cultura nas manifestações culturais da população afro-brasileira, no processo de formação, ensino e práxis docente, enriquecendo a experiência educacional e proporcionando diferentes formas de expressão e aprendizado para as gerações futuras.
PROBLEMATIKA PRAKTIK PEMBERIAN KETERANGAN AHLI HUKUM PIDANA DALAM PEMBUKTIAN TINDAK PIDANA KORUPSI
Authors: Effendi Erdianto 
Published: September 2024

Keterangan ahli adalah salah satu alat bukti yang digunakan dalam hukum acara pidana berdasarkan ketentuan Pasal 184 KUHAP. Keterangan ahli hukum pidana juga digunakan dalam pembuktian tindak pidana korupsi. Dalam praktik, terdapat beberapa masalah yang berkaitan dengan peranan ahli hukum pidana dalam pembuktian tindak pidana korupsi. Di antara masalah tersebut adalah tudingan tidak objektifnya para ahli dalam memberikan keterangan. Keterangan yang diberikan cenderung menguntungkan siapa yang menghadirkannya. Hasil penelitian secara empirik menemukan beberapa masalah dalam proses pembuktian yang menggunakan keterangan ahli hukum pidana. Beberapa masalah itu di antaranya : Hal apa yang harus dibuktikan oleh seorang ahli hukum pidana, siapa yang seharusnya menghadirkan ahli, apakah penyidik dan hakim terikat pada keterangan ahli hukum pidana, apakah para ahli yang memberikan keterangan berkaitan dengan biaya operasional dan honorarium, serta pertanyaan-pertanyaan lainnya yang belum ditemukan jawabannya secara yuridis. Berdasarkan temuan tersebut diharapkan ada pengaturan yang jelas terkait peranan ahli hukum pidana dalam pembuktian tindak pidana korupsi.
Association of Borrelia burgdorferi with nuchal bursitis and elevated outer surface protein A–specific serum antibodies in horses of the northeastern United States
Authors: Pearson Erin K. , Guarino Cassandra , Cercone Marta , Divers Thomas , Lambert Jenna , García-López José , Johnson Amy L. , Engiles Julie B. , Marconi Richard , Smith Jade , Brown Kara , Pinn-Woodcock Toby 
Published: September 2024

Abstract

OBJECTIVE
Evaluate the incidence of Borrelia burgdorferi in cases of equine nuchal bursitis (NB) and investigate the relationship between elevated serum outer surface protein A (OspA) antibodies and the molecular identification of B burgdorferi in bursal tissue or synovial fluid. Additionally, describe clinical cases and compare the histologic changes in NB with and without detection of B burgdorferi.

METHODS
This was a retrospective multicenter cohort study (2013 to 2022). Medical records from horses with a diagnosis of NB and B burgdorferi PCR testing on NB tissue or synovial fluid were reviewed. The study population included 11 horses with a postmortem diagnosis of NB, 19 horses from the northeastern US with an antemortem diagnosis of B burgdorferi PCR–positive NB, and 15 healthy controls without evidence of NB and unvaccinated for B burgdorferi. Where serum was available, Lyme multiplex assay results were compared with controls and ELISAs targeting individual B burgdorferi antigens were performed. Histologic findings in nuchal bursa tissue were compared between NB cases with and without B burgdorferi PCR detection.

RESULTS
Serum OspA antibody values in B burgdorferi–positive NB cases (n = 13) were significantly elevated (P < .001) compared to controls (15), and OspA was the predominant antigen detected by ELISA (8). Histopathology did not vary between NB cases with (n = 9) and without (6) B burgdorferi PCR detection.

CONCLUSIONS
The presence of B burgdorferi in the nuchal bursa of horses is associated with increased serum OspA antibodies.

CLINICAL RELEVANCE
The role of B burgdorferi in equine NB may be underestimated, and targeted therapy requires investigation.