bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond Crisis and Emergency: Climate Change as a Political Epic
Authors: Maloy J. S. 
Published: October 2024

AbstractThe available choices of political responses to disruption in the global climatic system depend in part on how the problem is conceptualized. Researchers and policymakers often invoke a “climate crisis” or “climate emergency,” but such language fits poorly with current knowledge of the problem's physical causes and social impacts. This article argues that climate change is instead more like a political epic. It involves neither sudden onset, as in the concept of emergency, nor decisive resolution, as in the concept of crisis, but rather a protracted ordeal of (temporally) obscure origins and uncertain outcomes. This alternative ontology of climate change highlights its novel temporal properties, including unusually slow-moving or time-lagged causal dynamics, with unsettling implications for academic research on the climatic-institutional nexus. Normatively, it undermines arguments for democracies’ environmental superiority over autocracies that rely on the former's general superiority at resolving crises and responding to emergencies. At the same time, some new arguments for democratic distributions of power become possible within the epic frame. More broadly, embracing the assumption of epic climate change may redirect attention from Promethean, managerial, or technocratic solutions to questions about which values or identities deserve preservation amid presumptively interminable and imperfectly remediable sources of disorder.
LA VERSION ARABE DE LA MESURE DU CERCLE D'ARCHIMÈDE I
Authors: Rashed Roshdi 
Published: October 2024

RésuméDepuis son édition par Heiberg au XIXe s., on savait que le texte grec de La mesure du cercle d'Archimède qui nous est parvenu est fautif, altéré par l'intervention d'un compilateur. Pour certaines de ses parties au moins, il est donc d'une authenticité douteuse. Plus récemment, l'examen de la traduction latine (au IXe siècle) de la traduction arabe de ce texte a permis de conclure que le manuscrit grec traduit appartient à une tradition textuelle meilleure et plus ancienne que le texte édité par Heiberg. Dans cette étude, on trouve l'editio princeps de la traduction arabe de La mesure du cercle, sa première traduction et une analyse historique et mathématique. Les nombreuses lectures de cette traduction faites au cours des siècles ont inspiré plusieurs « rédactions ». Trois d'entre elles seront éditées, traduites et examinées dans une prochaine étude.
TWO QUESTIONS: THE MASʾALATĀN AND THE AVICENNIAN CORPUS
Authors: Lánczky István 
Published: October 2024

AbstractThis article brings to light a previously unedited short treatise, the Masʾalatān (Two Questions), attributed to Avicenna (d. 1037). While the earliest witness to the text is the Ayasofya 4853 manuscript, containing a substantial portion of Avicenna's Nachlass, some of which is integrated into the Mubāḥaṯāt and Taʿlīqāt, the Masʾalatān has remained a standalone work with limited circulation. Consequently, the primary concern revolves around the verification of its authenticity and its feasibility given the available data. This article presents a critical edition of the text alongside a parallel translation but it also serves as a case study on the possibilities of authorship verification. It also compiles information from codicology, nevertheless, it primarily focuses on the commentary that analyses and compares the arguments to Avicenna's unquestionably authentic solutions. The first question addresses whether every existent is spatially located, while the second explores the impossibility of an actual infinite body. The commentary endeavors to interpret the text against the cultural and theological background that may have inspired such inquiries, meanwhile also seeks to address its later influence. In addition to unveiling a hitherto unseen text to the scholarly community for further research, it also offers an insight into the limitations of authorship attribution.
Rice cultivar tolerance to florpyrauxifen-benzyl spray-applied vs. coated on urea
Authors: Cotter Bodie L. , Norsworthy Jason K. , Butts Thomas R. , Roberts Trenton L. , Mauromoustakos Andy 
Published: October 2024

Abstract
Complaints regarding the sensitivity of rice to florpyrauxifen-benzyl and off-target movement of the herbicide occurred following its commercial launch in 2018 in the midsouthern United States. These two concerns encouraged the exploration of an alternative application method for florpyrauxifen-benzyl in rice. A field study was conducted in 2020 and 2021 to determine if coating florpyrauxifen-benzyl on urea would reduce negative impacts of the herbicide to rice. Five commercial rice lines were evaluated: ‘Diamond’, ‘Titan’, ‘RT7321 FP’, ‘RT7521 FP’, and ‘XP753’. Florpyrauxifen-benzyl coated on urea at a 2× rate (60 g ai ha–1) reduced rice injury in one of five commercial rice lines in 2020 and four of five commercial rice lines in 2021, compared to spray applications at the same rate. In 2020, ‘RT7521 FP’ exhibited a 17-percentage point injury reduction when coating florpyrauxifen-benzyl on urea at a 2× rate vs. the same rate sprayed. In 2021, rice injury was reduced by 26, 10, and 27 percentage points in the commercial rice lines ‘Diamond’, ‘Titan’, and ‘XP753’, respectively, following coated urea vs. spray applications at 4 wk after treatment (WAT). ‘XP753’ exhibited reduced injury (15 percentage points) by coating florpyrauxifen-benzyl at a 1× rate (30 g ai ha–1) 4 WAT in 2021, and another, ‘Diamond’, had comparable groundcover to nontreated plots when florpyrauxifen-benzyl was coated on urea at a 1× rate rather than the reductions observed from the spray application at a 2× rate. Yield differences were a function of urea rate rather than application method, where in six out of ten instances greater rough rice grain yield occurred at the higher rate. Findings from this experiment indicate that coating florpyrauxifen-benzyl on urea can reduce the amount of injury observed, especially in areas of overlap where you would have a 2× rate.
Change in Wind Renewable Energy Potential Under Stratospheric Aerosol Injections
Authors: Baur Susanne , Sanderson Benjamin M. , Séférian Roland , Terray Laurent 
Published: October 2024

AbstractWind renewable energy (WRE) is an essential component of the global sustainable energy portfolio. Recently, there has been increasing discussion on the potential supplementation of this conventional mitigation portfolio with Solar Radiation Modification (SRM). However, the impact of SRM on conventional mitigation measures has received limited attention to date. In this study, we explore one part of this impact, the potential effect of one type of SRM, Stratospheric Aerosol Injections (SAI), on WRE. Using hourly output from the Earth System Model CNRM‐ESM2‐1, we compare WRE potential under a medium emission scenario (SSP245) and a high emission scenario (SSP585) with an SRM scenario that has SSP585 baseline conditions and uses SAI to offset warming to approximately SSP245 global warming levels. Our results suggest that SAI may affect surface wind resources by modifying large‐scale circulation patterns, such as a significant poleward jet‐shift in the Southern Hemisphere. The modeled total global WRE potential is negligibly reduced under SAI compared to the SSP‐scenarios. However, regional trends are highly variable, with large increases and decreases in WRE potential frequently reaching 12% across the globe with SAI. This study highlights potential downstream effects of SRM on climatic elements, such as wind patterns, and offers perspectives on its implications for our mitigation efforts.
Rapid Acidification of the Arctic Chukchi Sea Waters Driven by Anthropogenic Forcing and Biological Carbon Recycling
Authors: Qi Di , Wu Yingxu , Chen Liqi , Cai Wei‐Jun , Yu Shujie , Ouyang Zhangxian , Zhang Yixing , Anderson Leif G. , Feely Richard A. , Zhuang Yanpei , Lin Hongmei , Lei Ruibo , Bi Haibo 
Published: October 2024

AbstractThe acidification of coastal waters is distinguished from the open ocean because of much stronger synergistic effects between anthropogenic forcing and local biogeochemical processes. However, ocean acidification research is still rather limited in polar coastal oceans. Here, we present a 16 year (2002–2018) observational dataset in the Chukchi Sea during the rapid sea‐ice melting season to determine the long‐term changes in pH and aragonite saturation state (Ωarag). We found that pH and Ωarag significantly declined in the water column with average rates of −0.0095 ± 0.0027 years−1 and −0.0333 ± 0.0098 years−1, respectively, and are 4–6 times faster than those solely due to increasing atmospheric CO2. We attributed the rapid acidification to the increased dissolved inorganic carbon owing to a combination of ice melt‐induced increased atmospheric CO2 invasion and subsurface remineralization induced by a stronger surface biological production as a result of the increased inflow of the nutrient‐rich Pacific water.
Inertia of Ionospheric Conductance During Electron Precipitation Events
Authors: Khazanov George V. , Kang Suk‐Bin , Glocer Alex 
Published: October 2024

AbstractUsing the SuperThermal Electron Transport (STET) model coupled with the Super‐thermal Proton Electron Atomic Hydrogen—tRansport in the Ionosphere and Thermosphere (SPEAH‐RIT) codes, we demonstrate that temporal variability of ionospheric conductance is defined by several time scales: the temporal variations of the magnetospheric source, the start time of electron precipitation, and the termination of the corresponding source. In these cases, the time scales are defined by dissipation of energetic electrons and effective recombination processes. The results presented in this paper were applied in the regions of pulsating aurora and polar arcs, demonstrating the fact that ionospheric conductance requires some time to form and decay. These time delays constitute an effective “inertia” in the conductance calculation which is not accounted for in many global models which assume an instantaneous connection between precipitation and conductance. Ionospheric conductance inertia influences the temporal variation in ionospheric and magnetospheric electric fields, and as a result, impacts magnetosphere‐ionosphere (MI) dynamics on a global scale.
Impact of EMIC Waves on Electron Flux Dropouts Measured by GPS Spacecraft: Insights From ELFIN
Authors: Mourenas Didier , Artemyev Anton V. , Zhang Xiao‐Jia , Angelopoulos Vassilis 
Published: October 2024

AbstractAlthough the effects of electromagnetic ion cyclotron (EMIC) waves on the dynamics of the Earth's outer radiation belt have been a topic of intense research for more than 20 years, their influence on rapid dropouts of electron flux has not yet been fully assessed. Here, we make use of contemporaneous measurements on the same ‐shell of trapped electron fluxes at 20,000 km altitude by Global Positioning System (GPS) spacecraft and of trapped and precipitating electron fluxes at 450 km altitude by Electron Losses and Fields Investigation (ELFIN) CubeSats in 2020–2022, to investigate the impact of EMIC wave‐driven electron precipitation on the dynamics of the outer radiation belt below the last closed drift shell of trapped electrons. During six of the seven selected events, the strong 1–2 MeV electron precipitation measured at ELFIN, likely driven by EMIC waves, occurs within 1–2 hr from a dropout of relativistic electron flux at GPS spacecraft. Using quasi‐linear diffusion theory, EMIC wave‐driven pitch angle diffusion rates are inferred from ELFIN measurements, allowing us to quantitatively estimate the corresponding flux drop based on typical spatial and temporal extents of EMIC waves. We find that EMIC wave‐driven electron precipitation alone can account for the observed dropout magnitude at 1.5–3 MeV during all events and that, when dropouts extend down to 0.5 MeV, a fraction of electron loss may sometimes be due to EMIC waves. This suggests that EMIC wave‐driven electron precipitation could modulate dropout magnitude above 1 MeV in the heart of the outer radiation belt.
Impact of WindBorne Observation Assimilation on Prediction of a TPV Merger Case From THINICE
Authors: Johnson Aaron , Wang Xuguang , Hutchinson Todd , Creus‐Costa Joan 
Published: October 2024

AbstractThe impact of assimilating in situ temperature, moisture and wind observations from a WindBorne Systems balloon, with long duration and adjustable ballast, is evaluated using a case study from the 2022 THINICE field campaign. A case is selected wherein the WindBorne balloon directly sampled a jet streak associated with a tropopause polar vortex (TPV). The observed TPV merged with another TPV at the same time as a downstream Arctic cyclone (AC) redeveloped eastward. The case is used to better understand the role of the observed TPV in the evolution of the downstream AC. The assimilation of the WindBorne observations improves the forecast track and amplitude of the TPV during the ∼1 day forecast period that the TPV can be tracked as a distinct feature. The root mean square error of temperature at 350 hPa is improved by the WindBorne assimilation throughout the 2.5 day forecast period. The surface cyclone track forecast is improved by the WindBorne assimilation during the period of eastward redevelopment of the surface cyclone, and the sea level pressure RMSE in the surrounding region is reduced during the first ∼1.5 days of forecast lead time. Results demonstrate the capability of the long‐duration controllable WindBorne balloons to improve the analysis of the TPV associated with the jet streak, leading to improved forecast of both tropopause‐level and surface pressure features. Additionally, the importance of observing the upstream TPV amplitude for improving forecasts of the process of TPV merging and its impact on the evolution and longevity of the mature AC is confirmed.
Dichotomous intronic polyadenylation profiles reveal multifaceted gene functions in the pan-cancer transcriptome
Authors: Sun Jiao , Kim Jin-Young , Jun Semo , Park Meeyeon , de Jong Ebbing , Chang Jae-Woong , Cheng Sze , Fan Deliang , Chen Yue , Griffin Timothy J. , Lee Jung-Hee , You Ho Jin , Zhang Wei , Yong Jeongsik 
Published: October 2024

AbstractAlternative cleavage and polyadenylation within introns (intronic APA) generate shorter mRNA isoforms; however, their physiological significance remains elusive. In this study, we developed a comprehensive workflow to analyze intronic APA profiles using the mammalian target of rapamycin (mTOR)-regulated transcriptome as a model system. Our investigation revealed two contrasting effects within the transcriptome in response to fluctuations in cellular mTOR activity: an increase in intronic APA for a subset of genes and a decrease for another subset of genes. The application of this workflow to RNA-seq data from The Cancer Genome Atlas demonstrated that this dichotomous intronic APA pattern is a consistent feature in transcriptomes across both normal tissues and various cancer types. Notably, our analyses of protein length changes resulting from intronic APA events revealed two distinct phenomena in proteome programming: a loss of functional domains due to significant changes in protein length or minimal alterations in C-terminal protein sequences within unstructured regions. Focusing on conserved intronic APA events across 10 different cancer types highlighted the prevalence of the latter cases in cancer transcriptomes, whereas the former cases were relatively enriched in normal tissue transcriptomes. These observations suggest potential, yet distinct, roles for intronic APA events during pathogenic processes and emphasize the abundance of protein isoforms with similar lengths in the cancer proteome. Furthermore, our investigation into the isoform-specific functions of JMJD6 intronic APA events supported the hypothesis that alterations in unstructured C-terminal protein regions lead to functional differences. Collectively, our findings underscore intronic APA events as a discrete molecular signature present in both normal tissues and cancer transcriptomes, highlighting the contribution of APA to the multifaceted functionality of the cancer proteome.
Erythropoiesis: insights from a genomic perspective
Authors: Cha Hye Ji 
Published: October 2024

AbstractErythropoiesis, the process underlying the production of red blood cells, which are essential for oxygen transport, involves the development of hematopoietic stem cells into mature red blood cells. This review focuses on the critical roles of transcription factors and epigenetic mechanisms in modulating gene expression critical for erythroid differentiation. It emphasizes the significance of chromatin remodeling in ensuring gene accessibility, a key factor for the orderly progression of erythropoiesis. This review also discusses how dysregulation of these processes can lead to erythroid disorders and examines the promise of genome editing and gene therapy as innovative therapeutic approaches. By shedding light on the genomic regulation of erythropoiesis, this review suggests avenues for novel treatments for hematological conditions, underscoring the need for continued molecular studies to improve human health.
YAP promotes global mRNA translation to fuel oncogenic growth despite starvation
Authors: Hwang Daehee , Baek Seonguk , Chang Jeeyoon , Seol Taejun , Ku Bomin , Ha Hongseok , Lee Hyeonji , Cho Suhyeon , Roh Tae-Young , Kim Yoon Ki , Lim Dae-Sik 
Published: October 2024

AbstractYes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) play fundamental roles in stem/progenitor cell expansion during homeostasis, and their dysregulation often leads to tissue overgrowth. Here, we show that YAP activation is sufficient to overcome the restriction of global protein synthesis induced by serum starvation, enabling cells to sustain proliferation and survival despite an unfavorable environment. Mechanistically, YAP/TAZ selectively promoted the mTORC1-dependent translation of mRNAs containing 5′ terminal oligopyrimidine (5′TOP) motifs, ultimately increasing the cellular polysome content. Interestingly, DNA damage-inducible transcript 4 (DDIT4), a negative regulator of mTORC1, was upregulated by serum starvation but repressed by YAP/TAZ. DDIT4 was sufficient to suppress the translation and transformative potential of uveal melanoma cells, which are often serum unresponsive due to G protein mutations. Our findings reveal a vital role for protein synthesis as a key modality of YAP/TAZ-induced oncogenic transformation and indicate the potential for targeting mTORC1 or translation to treat YAP/TAZ-driven malignancies.
Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2
Authors: Jo Yunju , Sim Hye-In , Yun Bohwan , Park Yoon , Jin Hyung-seung 
Published: October 2024

AbstractCancer immunotherapy aims to initiate or amplify immune responses that eliminate cancer cells and create immune memory to prevent relapse. Immune checkpoint inhibitors (ICIs), which target coinhibitory receptors on immune effector cells, such as CTLA-4 and PD-(L)1, have made significant strides in cancer treatment. However, they still face challenges in achieving widespread and durable responses. The effectiveness of anticancer immunity, which is determined by the interplay of coinhibitory and costimulatory signals in tumor-infiltrating immune cells, highlights the potential of costimulatory receptors as key targets for immunotherapy. This review explores our current understanding of the functions of CD2 and CD226, placing a special emphasis on their potential as novel agonist targets for cancer immunotherapy. CD2 and CD226, which are present mainly on T and NK cells, serve important functions in cell adhesion and recognition. These molecules are now recognized for their costimulatory benefits, particularly in the context of overcoming T-cell exhaustion and boosting antitumor responses. The importance of CD226, especially in anti-TIGIT therapy, along with the CD2‒CD58 axis in overcoming resistance to ICI or chimeric antigen receptor (CAR) T-cell therapies provides valuable insights into advancing beyond the current barriers of cancer immunotherapy, underscoring their promise as targets for novel agonist therapy.
CBL-b E3 ligase-mediated neddylation and activation of PARP-1 induce vascular calcification
Authors: Kwon Duk-Hwa , Shin Sera , Nam Yoon Seok , Choe Nakwon , Lim Yongwoon , Jeong Anna , Lee Yun-Gyeong , Kim Young-Kook , Kook Hyun 
Published: October 2024

AbstractVascular calcification (VC) refers to the accumulation of mineral deposits on the walls of arteries and veins, and it is closely associated with increased mortality in cardiovascular disease patients, particularly among high-risk patients with diabetes and chronic kidney disease (CKD). Neuronal precursor cell-expressed developmentally downregulated protein 8 (NEDD8) is a ubiquitin-like protein that plays a pivotal role in various cellular functions, primarily through its conjugation to target proteins and subsequent relay of biological signals. However, the role of NEDDylation in VC has not been investigated. In our study, we observed that MLN4924, an inhibitor of the NEDD8-activating E1 enzyme, effectively impedes the progression of VC. LC‒MS/MS analysis revealed that poly(ADP‒ribose) polymerase 1 (PARP-1) is subjected to NEDD8 conjugation, leading to an increase in PARP-1 activity during VC. We subsequently revealed that PARP-1 NEDDylation is mediated by the E3 ligase CBL proto-oncogene B (CBL-b) and is reversed by NEDD8-specific protease 1 (NEDP-1) during VC. Furthermore, the CBL-b C373 peptide effectively mitigated the inactive form of the E3 ligase activity of CBL-b, ultimately preventing VC. These findings provide compelling evidence that the NEDD8-dependent activation of PARP-1 represents a novel mechanism underlying vascular calcification and suggests a promising new therapeutic target for VC.
MAT2B regulates the protein level of MAT2A to preserve RNA N6-methyladenosine
Authors: Wan Xinyi , Zeng Weiwu , Fan Haonan , Wang Chenliang , Han Shixun , Sun Zhongxing , Tang Mei , Shao Juejia , Liu Yu , Fang Yuan , Jia Junqi , Tang Yin , Zhang Yanjun , Zhao Bin , Fang Dong 
Published: October 2024

AbstractMAT2B works together with MAT2A to synthesize S-Adenosyl methionine (SAM) as the primary methyl donor. MAT2B, despite lacking catalytic activity, exerts regulatory control over the enzymatic activity of MAT2A. In addition to the enzymatic activity regulation, we find that, in an NADP+-dependent manner, MAT2B binds and stabilizes MAT2A. Disruption of the cellular NADP+remodels the protein level of MAT2A. The pentose phosphatase pathway regulates the level of MAT2A protein through the interaction of NADP+with MAT2B. Additionally, MAT2B-MAT2A interaction regulates the mRNA m6A modification and stability. In liver tumors, theMat2amRNA level is elevated but the protein level is decreased by the restricted NADP+. Blocking the interaction between MAT2B and MAT2A by the keto diet can suppress liver tumor growth. These findings reveal that MAT2B is essential for regulating the protein levels of MAT2A and connecting SAM synthesis to mRNA m6A.