bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Trishistidine Pseudopeptide with Ability to Remove Both CuΙ and CuΙΙ from the Amyloid‐β Peptide and to Stop the Associated ROS Formation
Authors: Conte‐Daban Amandine , Boff Bastien , Candido Matias Andreza , Aparicio Claudia N. Montes , Gateau Christelle , Lebrun Colette , Cerchiaro Giselle , Kieffer Isabelle , Sayen Stéphanie , Guillon Emmanuel , Delangle Pascale , Hureau Christelle 
Published: August 2017

AbstractThe pseudopeptide L, derived from a nitrilotriacetic acid scaffold and functionalized with three histidine moieties, is reminiscent of the amino acid side chains encountered in the Alzheimer's peptide (Aβ). Its synthesis and coordination properties for CuΙ and CuΙΙ are described. L efficiently complex CuΙΙ in a square‐planar geometry involving three imidazole nitrogen atoms and an amidate–Cu bond. By contrast, CuΙ is coordinated in a tetrahedral environment. The redox behavior is irreversible and follows an ECEC mechanism in accordance with the very different environments of the two redox states of the Cu center. This is in line with the observed resistance of the CuΙ complex to oxidation by oxygen and the CuΙΙ complex reduction by ascorbate. The affinities of L for CuΙΙ and CuΙ at physiological pH are larger than that reported for the Aβ peptide. Therefore, due to its peculiar Cu coordination properties, the ligand L is able to target both redox states of Cu, redox silence them and prevent reactive oxygen species production by the CuAβ complex. Because reactive oxygen species contribute to the oxidative stress, a key issue in Alzheimer's disease, this ligand thus represents a new strategy in the long route of finding molecular concepts for fighting Alzheimer's disease.
Titanocene Silylpropyne Complexes: Promising Intermediates en route to a Four‐Membered 1‐Metallacyclobuta‐2,3‐diene?
Authors: Reiß Fabian , Reiß Melanie , Spannenberg Anke , Jiao Haijun , Hollmann Dirk , Arndt Perdita , Rosenthal Uwe , Beweries Torsten 
Published: August 2017

AbstractCoordination of the alkyl‐substituted alkynes Me3SiC2CH2R (1: R=SiMe3; 2: R=N(SiMe3)2) to titanocene centres [Cp′2Ti] (Cp′=Cp, Cp*) yields stable alkyne complexes of the type Cp′2Ti(η2‐Me3SiC2CH2R) (3: Cp′=Cp, R=SiMe3; 5: Cp′=Cp, R=N(SiMe3)2; 6: Cp′=Cp*, R=SiMe3) that are not prone to alkyne/allene isomerisation. When reacting alkyne 2 with Cp*2TiCl2 and Mg formation of the complex Cp*2Ti(III)(η3‐Me3SiC2CH2) (7) which displays a propargylic unit coordinated to the TiIII centre takes place. All complexes were fully characterised, the molecular structures for 5, 6, and 7 are discussed.
Designed Synthesis of Au/Fe3O4@C Janus Nanoparticles for Dual‐Modal Imaging and Actively Targeted Chemo‐Photothermal Synergistic Therapy of Cancer Cells
Authors: Zhang Qi , Zhang Lingyu , Li Shengnan , Chen Xiangjun , Zhang Manjie , Wang Tingting , Li Lu , Wang Chungang 
Published: August 2017

AbstractElaborately designed novel multifunctional Janus nanoparticles (JNPs) have attracted considerable attention owing to their anisotropic surface properties and various functionalities that allow them to house several components for the detection and targeting of cancer cells. In this work, we report a novel and facile approach to synthesize Au/Fe3O4@C JNPs, which were further selectively functionalized with amino‐poly(ethylene glycol)thiol (NH2‐PEG‐SH) and folic acid (FA) on the exposed Au domains to achieve high contrast for X‐ray computed tomography (CT) imaging, excellent stability, good biocompatibility, as well as cancer cell‐specific targeting. Meanwhile, the other Fe3O4@C sides with mesoporous structure served as a drug delivery vehicle for doxorubicin (DOX), an efficient photothermal therapy (PTT) agent, and a magnetic resonance (MR) imaging contrast agent. Taking these features together, these unique multifunctional JNPs provide an intriguing nanoplatform for dual‐modal CT and MR imaging‐guided actively targeted chemo‐photothermal synergistic cancer therapy.
Syntheses of Exceptionally Stable Aluminum(III) Metal–Organic Frameworks: How to Grow High‐Quality, Large, Single Crystals
Authors: Guo Yuanyuan , Zhang Jun , Dong Long‐Zhang , Xu Yan , Han Wei , Fang Min , Liu Hong‐Ke , Wu Yong , Lan Ya‐Qian 
Published: August 2017

AbstractThe difficulty of obtaining large single crystals of aluminum carboxylate metal–organic frameworks (MOFs) for structure determinations has limited the development of these water and thermally stable MOFs. Herein, how large single crystals of known MIL‐53(Al) and the first two tetrahedral ligand‐based, visible‐light‐absorbing 3D Al‐MOFs, [Al3(OH)3(HTCS)2] (AlTCS‐1) and [Al5O2(OH)3(TCS)2(H2O)2] (AlTCS‐2; TCS=tetrakis(4‐oxycarbonylphenyl)silane), are obtained in the presence of hydrofluoric or formic acid for conventional single‐crystal diffraction measurements is presented. The technique of obtaining those single crystals has potential to be a general method for obtaining large and good‐quality single crystals of Al‐MOFs. AlTCS‐1 and ‐2 are stable over a wide pH range (1–11), and AlTCS‐1 is even stable in aqua regia solution for at least 24 h. The BET specific surface areas of AlTCS‐1 and ‐2 are 11 and 1506 m2 g−1, respectively. AlTCS‐2 takes up 51 cm3 (STP) g−1 CO2 and 15 cm3 (STP) g−1 CH4 at 298 K and 1 bar, which is relatively high among MOF materials. AlTCS‐1 takes up 30 cm3 g−1 CO2 and 4.2 cm3 g−1 CH4 at 298 K and 1 bar. The rapid and stable photocurrent responses of AlTCS‐1 and ‐2 under UV and visible‐light illumination are observed. Moreover, AlTCS‐1 photocatalyzes the water‐splitting reaction under visible light with an average hydrogen evolution efficiency of 50 μmol g−1 h−1 for the first 10 h in a mixture of water and triethanolamine.
Cognitive Challenges of Changeability: Multi‐Level Flexibility for Operating a Modular Chemical Plant
Authors: Müller Romy , Urbas Leon 
Published: August 2017

AbstractIn changeable modular plants, the goal conflicts implied in adjusting the plant to current demands call for flexible strategy selection by operators on three levels: intervention, decision making, and cognitive meta‐control. The first level refers to making appropriate changes to the system. This requires flexibility on the second level. Flexibility in operators' choice of intervention and decision strategies depends on the third level, which enables a balance between stability and flexibility. The challenges resulting from these flexibility requirements are discussed by reviewing the literature on adaptive decision making and action control in volatile environments.
Pedal peptide/orcokinin‐type neuropeptide signaling in a deuterostome: The anatomy and pharmacology of starfish myorelaxant peptide in Asterias rubens
Authors: Lin Ming , Egertová Michaela , Zampronio Cleidiane G. , Jones Alexandra M. , Elphick Maurice R. 
Published: August 2017

AbstractPedal peptide (PP) and orcokinin (OK) are related neuropeptides that were discovered in protostomian invertebrates (mollusks, arthropods). However, analysis of genome/transcriptome sequence data has revealed that PP/OK‐type neuropeptides also occur in a deuterostomian phylum—the echinoderms. Furthermore, a PP/OK‐type neuropeptide (starfish myorelaxant peptide, SMP) was recently identified as a muscle relaxant in the starfish Patiria pectinifera. Here mass spectrometry was used to identify five neuropeptides (ArPPLN1a‐e) derived from the SMP precursor (PP‐like neuropeptide precursor 1; ArPPLNP1) in the starfish Asterias rubens. Analysis of the expression of ArPPLNP1 and neuropeptides derived from this precursor in A. rubens using mRNA in situ hybridization and immunohistochemistry revealed a widespread pattern of expression, with labeled cells and/or processes present in the radial nerve cords, circumoral nerve ring, digestive system (e.g., cardiac stomach) and body wall‐associated muscles (e.g., apical muscle) and appendages (e.g., tube feet and papulae). Furthermore, our data provide the first evidence that neuropeptides are present in the lateral motor nerves and in nerve processes innervating interossicular muscles. In vitro pharmacological tests with SMP (ArPPLN1b) revealed that it causes dose‐dependent relaxation of apical muscle, tube foot and cardiac stomach preparations from A. rubens. Collectively, these anatomical and pharmacological data indicate that neuropeptides derived from ArPPLNP1 act as inhibitory neuromuscular transmitters in starfish, which contrasts with the myoexcitatory actions of PP/OK‐type neuropeptides in protostomian invertebrates. Thus, the divergence of deuterostomes and protostomes may have been accompanied by an inhibitory–excitatory transition in the roles of PP/OK‐type neuropeptides as regulators of muscle activity.
Distribution of tachykinin‐related peptides in the brain of the tobacco budworm Heliothis virescens
Authors: Zhao Xin‐Cheng , Xie Gui‐Ying , Berg Bente G. , Schachtner Joachim , Homberg Uwe 
Published: August 2017

AbstractInvertebrate tachykinin‐related peptides (TKRPs) comprise a group of signaling molecules having sequence similarities to mammalian tachykinins. A growing body of evidence has demonstrated the presence of TKRPs in the central nervous system of insects. In this investigation, we used an antiserum against locustatachykinin‐II to reveal the distribution pattern of these peptides in the brain of the moth Heliothis virescens. Immunolabeling was found throughout the brain of the heliothine moth. Most of the roughly 500 locustatachykinin‐II immunoreactive cell bodies, that is, ca. 400, were located in the protocerebrum, whereas the rest was distributed in the deutocerebrum, tritocerebrum, and the gnathal ganglion. Abundant immunoreactive processes were located in the same regions. Labeled processes in the protocerebrum were especially localized in optic lobe, central body, lateral accessory lobe, superior protocerebrum, and lateral protocerebrum, while those in the deutocerebrum were present exclusively in the antennal lobe. In addition to brain interneurons, four pairs of median neurosecretory cells in the pars intercerebralis with terminal processes in the corpora cardiaca and aorta wall were immunostained. No sexual dimorphism in immunoreactivity was found. Comparing the data obtained here with findings from other insect species reveals considerable differences, suggesting species‐specific roles of tachykinin‐related peptides in insects.
Rectifiability of Varifolds with Locally Bounded First Variation with Respect to Anisotropic Surface Energies
Authors: De Philippis Guido , De Rosa Antonio , Ghiraldin Francesco 
Published: August 2017

AbstractWe extend Allard's celebrated rectifiability theorem to the setting of varifolds with locally bounded first variation with respect to an anisotropic integrand. In particular, we identify a sufficient and necessary condition on the integrand to obtain the rectifiability of every d‐dimensional varifold with locally bounded first variation and positive d‐dimensional density. In codimension 1, this condition is shown to be equivalent to the strict convexity of the integrand with respect to the tangent plane.© 2017 Wiley Periodicals, Inc.
Highly Efficient Sorption of Methyl Orange by a Metal–Organic Resin–Alginic Acid Composite
Authors: Pournara Anastasia D. , Rapti Sofia , Skliri Euaggelia , Armatas Gerasimos S. , Tsipis Athanassios C. , Manos Manolis J. 
Published: August 2017

AbstractThe composite anion‐exchange material MOR‐1–HA (metal–organic resin‐1–alginic acid) was investigated as sorbent for the capture of the methyl orange anion (MO−) from aqueous solutions. MOR‐1–HA shows a remarkably high sorption capacity (up to 859 mg g−1) and rapid sorption kinetics, the fastest among the reported metal–organic sorbents. It is capable of absorbing MO− over a wide pH range (1–8) and, in addition, it exhibits significant MO− sorption affinity even in the presence of large excesses of competing anions (e.g., Cl−, NO3−, SO42−). The exceptional MO−‐sorption properties of MOR‐1–HA arise not only from its highly porous structure and easily exchangeable Cl− anions, but also from a multitude of interaction effects, such as electrostatic interactions between MO− and the NH3+ groups of the material, hydration/dehydration, hydrophobicity/hydrophilicity, size and capacity of generating lateral interactions, and intercalation as revealed by theoretical studies. An ion‐exchange column with a stationary phase containing MOR‐1–HA and silica sand showed high efficiency for the removal of MO− from various types of aqueous samples. The column can be readily regenerated and reused for many runs with minimal loss (2.3–9.3 %) of its exchange capacity. The simplicity of the MOR‐1–HA/sand column and its high regeneration capability and reusability make it particularly attractive for application in the remediation of MO−‐contaminated industrial wastewater.
Cysticercosis: Reiterating the role of cytodiagnosis
Authors: Pal Shweta , Singh Neha , Chowdhury Nilotpal , Huda Farhanul , Rao Shalinee 
Published: August 2017

BackgroundCysticercosis is a common parasitic infection in many Asian countries. The histopathological features of this parasitic infection are well established, however, the subtle cytological features and their importance in diagnosing this condition need more elaboration. In this case series we have reiterated the role of fine‐needle aspiration cytology (FNAC) in the diagnosis of cysticercosis in clinically unsuspected cases, thereby obviating the need for a biopsy.MethodsSixteen patients presented with palpable subcutaneous swellings. The clinical diagnosis varied from tubercular/reactive lymphadenitis, lipoma to neurofibromatosis. These patients were subjected to FNAC of the swellings.ResultIn all 16 cases, a definitive diagnosis of cysticercosis was made on FNAC on the basis of characteristic features like parasite tegument/bladder wall and occasional hooklets. Features suggestive of host reaction were also observed, which included multinucleated giant cells, mixed inflammatory infiltrate with conspicuous eosinophils, histiocytes, and palisading granulomas. These findings were correlated with histopathology and patients were followed up. We noticed spontaneous resolution of the nodules after the FNAC in six patients.ConclusionThe cytological diagnosis of cysticercosis is quite straightforward in cases where the actual parasitic structures are identified in the smears. However, in the absence of parasitic fragments, features suggestive of host reaction should alert the cytologist to search for the evidence of cysticercosis in the smear, which can help in early and timely diagnosis and treatment of the disease. We also postulate that injury to certain parts of the larval form during FNAC procedure would result in degeneration of the parasite.
An X‐linked Myh11‐CreERT2 mouse line resulting from Y to X chromosome‐translocation of the Cre allele
Authors: Liao Mingmei , Zhou Junmei , Wang Fen , Ali Yasmin H. , Chan Kelvin L. , Zou Fei , Offermanns Stefan , Jiang Zhisheng , Jiang Zhihua 
Published: August 2017

SummaryThe Myh11‐CreERT2 mouse line (Cre+) has gained increasing application because of its high lineage specificity relative to other Cre drivers targeting smooth muscle cells (SMCs). This Cre allele, however, was initially inserted into the Y chromosome (X/YCre+), which excluded its application in female mice. Our group established a Cre+ colony from male ancestors. Surprisingly, genotype screening identified female carriers that stably transmitted the Cre allele to the following generations. Crossbreeding experiments revealed a pattern of X‐linked inheritance for the transgene (k > 1000), indicating that these female carries acquired the Cre allele through a mechanism of Y to X chromosome translocation. Further characterization demonstrated that in hemizygous X/XCre+ mice Cre activity was restricted to a subset arterial SMCs, with Cre expression in arteries decreased by 50% compared to X/YCre+ mice. This mosaicism, however, diminished in homozygous XCre+/XCre+ mice. In a model of aortic aneurysm induced by a SMC‐specific Tgfbr1 deletion, the homozygous XCre+/XCre+ Cre driver unmasked the aortic phenotype that is otherwise subclinical when driven by the hemizygous X/XCre+ Cre line. In conclusion, the Cre allele carried by this female mouse line is located on the X chromosome and subjected to X‐inactivation. The homozygous XCre+/XCre+ mice produce uniform Cre activity in arterial SMCs.
Altered pain sensitivity and axioscapular muscle activity in neck pain patients compared with healthy controls
Authors: Christensen S.W. , Hirata R.P. , Graven‐Nielsen T. 
Published: August 2017

AbstractBackgroundPrevious studies have indicated that neck pain patients feel increased symptoms following upper limb activities, and altered axioscapular muscle function has been proposed as a contributing factor.MethodsPain sensitivity and muscle activity, during arm movements, were assessed in neck pain patients and controls. Patients with ongoing insidious‐onset neck pain (IONP, N = 16) and whiplash‐associated disorders (WAD, N = 9) were included along with sex‐ and age‐matched controls (N = 25). Six series of repeated arm abductions were performed during electromyographic (EMG) recordings from eight bilateral muscles. The first and last three series were separated by 8 min and 42 s, respectively. Each series consisted of three slow and three fast movements. Pressure pain thresholds (PPTs) were recorded bilaterally from neck, head and arm at baseline, after the third and sixth movement series. Pain intensity was recorded on an electronic visual analogue scale (VAS).ResultsLarger pain areas and higher VAS scores were found in patients compared with controls (p < 0.001), and in patients, the VAS scores increased in the course of movements (p < 0.02). PPTs were lower in patients compared with controls at all sites (p < 0.03), and these decreased during arm movements in the IONP group (p < 0.03), while increasing at head and neck sites in controls (p < 0.04). During the slow movements, increasing serratus anterior EMG activity was found in the series with short breaks in‐between for the WAD group compared with IONP and controls (p < 0.001).ConclusionAxioscapular movement caused different responses in pain sensitivity and muscle activity between neck pain patient groups compared with controls.SignificanceNeck pain patients report increased symptoms following upper limb activities. This study shows that repeated arm movements caused differentiated responses in pain sensitivity and muscle activity between subgroups of neck pain patient and asymptomatic controls. Such findings may be of great clinical significance when planning rehabilitation for this patient population.
Incorporation of Tetrazolium Blue (TB)/Gold Nanoparticles (GNPs) into Carbon Paste Electrode: Application as an Electrochemical Sensor for the Sensitive and Selective Determination of Sotalol in Micellar Medium
Authors: Mohamed Mona A. , Fekry Amany M. , El‐Shal Manal A. , Banks Craig E. 
Published: August 2017

AbstractThe electrochemical oxidation of Sotalol (SOT) based on Tetrazolium Blue (TB)/gold nanoparticles (GNPs)‐modified carbon paste electrodes (CPE) have been studied in the presence of sodium lauryl sulphate (SLS). Cyclic voltammetry (CV), differential pulse voltammetry (DPV), chronoamperometry and electrochemical impedance spectroscopy (EIS) techniques have all been utilized within this study. GNPs and TB have a synergetic effect‐giving rise to highly improved electrochemical responses and provide an advantageous platform for the basis of an electrochemical sensor with excellent performance. The experimental parameters, electrodeposition time, pH and scan rate have all been examined and optimized. The sensing of SOT via DPV is found to exhibit a wide linear dynamic range of 1.0×10−7–7.5×10−4 M in pH 2. LOD and LOQ were calculated and found to correspond to 2.5×10−8 M and 8.3×10−8 M, respectively. The suggested sensor has been used successfully for SOT determination in pharmaceutical samples and human urine as real samples. Satisfactory recoveries of analyte from these samples are demonstrated indicating that the suggested sensor is highly suitable for clinical analysis, quality control and a routine determination of SOT in pharmaceutical formulations.
Protein micropatterns printed on glass: Novel tools for protein‐ligand binding assays in live cells
Authors: Dirscherl Cindy , Springer Sebastian 
Published: August 2017

AbstractMicrometer‐sized patterns of proteins on glass or silica surfaces are in widespread use as protein arrays for probing with ligands or recombinant proteins. More recently, they have been used to capture the surface proteins of mammalian cells seeded onto them, and to arrange these surface proteins into pattern structures. Binding of small molecule ligands or of other proteins, transmembrane or intracellular, to these captured surface proteins can then be quantified. However, reproducible production of protein micropatterns on surfaces can be technically difficult. In this review, we outline the wide potential and the current practical uses of printed protein micropatterns in a historical overview, and we detail some potential pitfalls and difficulties from our own experience, as well as ways to circumvent them.
Enhanced Energy‐Storage Properties of Lanthanum‐Doped Bi0.5Na0.5TiO3‐Based Lead‐Free Ceramics
Authors: Yang Haibo , Yan Fei , Lin Ying , Wang Tong 
Published: August 2017

AbstractA series of Bi(0.5−x)Lax(Na0.82K0.18)0.5Ti0.96Zr0.02Sn0.02O3 (BNKTZS‐xL) (x=0–0.18) lead‐free ceramics were designed and fabricated by using a conventional solid‐state sintering method. The effects of the La3+ content on the properties of the BNKTZS‐xL ceramics were systematically investigated. Temperature‐dependent dielectric constant curves displayed two depressed anomalies, which resulted in significantly improved dielectric temperature stability. The polarization–electric field hysteresis loops illustrated that the addition of La3+ markedly enhanced the breakdown strength, energy‐storage density, and energy‐storage efficiency. A maximum energy‐storage density of 1.95 J cm−3 was obtained for the material with x=0.10, and the energy‐storage efficiency significantly improved from 28 to 85 % upon increasing the value of x from 0 to 0.18. These properties indicate that the BNKTZS‐xL ceramics may be promising lead‐free materials for high energy‐storage capacitor applications.