bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of novel homozygous SLURP1 mutation in a Javanese family with Mal de Meleda
Authors: Radiono Sunardi , Pramono Zacharias A. D. , Oh Glenda G. K. , Surana Uttam , Widiyani Syahfori , Danarti Retno 
Published: October 2017

AbstractBackgroundMal de Meleda (OMIM# 248300; keratosis palmoplantaris transgrediens) is an autosomal recessive form of palmoplantar keratoderma, clinically characterized by sharp demarcated erythema and hyperkeratosis of the palms and soles that progress with age and extend to the dorsal aspects of the hands and feet. The mal de Meleda is caused by mutations in the SLURP1 gene that encodes secreted lymphocyte antigen 6/urokinase‐type plasminogen receptor‐related protein 1 (SLURP1). To date no reported cases from Indonesia. The aims of the study were to describe the typical features of mal de Meleda cases in a Javanese family in Indonesia and identify the mutation in the ARS B gene which encodes SLURP1.Patients and MethodsIn this study, three Javanese patients, siblings from nonconsanguineous nonaffected parents, presented with classical symptoms of mal de Meleda. Genetic analysis screening SLURP1 gene was conducted for the specimens from the patients and other family members.ResultsA novel homozygous three‐nucleotide deletion in exon 3, i.e. c.271‐273TCTdel, was identified in the patients. Subcloning and sequencing revealed both parents (I.2 and I.3) and one of the father's siblings (I.1) carry heterozygous c.271‐273TCTdel, while the other father's sibling (I.2), the mother's sister (I.4), and a healthy control matched the ethnicity of the family, showing normal sequence of the entire SLURP1.ConclusionThis is the first mal de Meleda case of Javanese ethnicity to be documented, and the unique mutation has not previously been reported. The finding supports the notion that despite the rarity, SLURP1 mutation causing mal de Meleda is ubiquitous.
WHO guide on the economic evaluation of influenza vaccination
Authors: Newall Anthony T. , Chaiyakunapruk Nathorn , Lambach Philipp , Hutubessy Raymond C. W. 
Published: October 2017

AbstractInfluenza is responsible for substantial morbidity and mortality across the globe, with a large share of the total disease burden occurring in low‐ and middle‐income countries (LMICs). There have been relatively few economic evaluations assessing the value of seasonal influenza vaccination in LMICs. The purpose of this guide is to outline the key theoretical concepts and best practice in methodologies and to provide guidance on the economic evaluation of influenza vaccination in LMICs. It outlines many of the influenza vaccine‐specific challenges and should help to provide a framework for future evaluations in the area to build upon.
The (dis)embodiment of human capital development projects: the case of Vietnam before and within the global “race for talent”
Authors: Nguyen Chi Hong 
Published: October 2017

AbstractThis paper adds nuance to existing human capital theory by critiquing the rationality principle underpinning this theory that leads to the disembodiment of skills and knowledge. Accordingly, individual investment in education is said to be rationally calculated on a cost‐and‐benefit basis, and a collective of individual skills and knowledge enables social development. In contrast, by using the Heideggerian perspective of engagement with the world, it is argued in this article that such decisions can be affected and reshaped by individuals’ embodied interactions with others under the effects of socio‐political norms and practices. As such, investment in education and training and its outcomes are socially and politically shared and enacted. This argument is supported by an examination of the evolving human capital policies in Vietnam that disembody human capital from individuals’ embeddedness in the world. In Vietnam, human capital is considered as a diplomatic, political, economic, and innovative commodity for socioeconomic development and participation in global competition for talent. This public commodity is collective, symbolic, and quantifiable. This disembodied commodity is produced through a joint‐venture effort among individuals, the Vietnamese Government's exercise of multilateralism, other governments, and foreign universities.
A multicentre randomised controlled trial evaluating the efficacy of dehydrated human amnion/chorion membrane (EpiFix®) allograft for the treatment of venous leg ulcers
Authors: Bianchi Christian , Cazzell Shawn , Vayser Dean , Reyzelman Alexander M , Dosluoglu Hasan , Tovmassian Gregory ,   EpiFix VLU Study Group
Published: October 2017

AbstractA randomised, controlled, multicentre clinical trial was conducted to evaluate the efficacy of dehydrated human amnion/chorion membrane (EpiFix) allograft as an adjunct to multilayer compression therapy for the treatment of non‐healing full‐thickness venous leg ulcers. We randomly assigned 109 subjects to receive EpiFix and multilayer compression (n = 52) or dressings and multilayer compression therapy alone (n = 57). Patients were recruited from 15 centres around the USA and were followed up for 16 weeks. The primary end point of the study was defined as time to complete ulcer healing. Participants receiving weekly application of EpiFix and compression were significantly more likely to experience complete wound healing than those receiving standard wound care and compression (60% versus 35% at 12 weeks, P = 0·0128, and 71% versus 44% at 16 weeks, P = 0·0065). A Kaplan–Meier analysis was performed to compare the time‐to‐healing performance with or without EpiFix, showing a significantly improved time to healing using the allograft (log‐rank P = 0·0110). Cox regression analysis showed that subjects treated with EpiFix had a significantly higher probability of complete healing within 12 weeks (HR: 2·26, 95% confidence interval 1·25–4·10, P = 0·01) versus without EpiFix. These results confirm the advantage of EpiFix allograft as an adjunct to multilayer compression therapy for the treatment of non‐healing, full‐thickness venous leg ulcers.
“Meal realities” — An ethnographic exploration of hospital mealtime environment and practice
Authors: Ottrey Ella , Porter Judi , Huggins Catherine E. , Palermo Claire 
Published: October 2017

AbstractAimTo explore and understand patterns of mealtime culture, environment and social practice from the perspective of staff, volunteers and visitors on the hospital ward.BackgroundInadequate food intake is a common and complex problem in hospital and can lead to malnutrition. Mealtime interventions have been implemented to address this problem with limited success. A better understanding of mealtime environment and practice is needed to ascertain which interventions are more likely to be effective in addressing inadequate food intake in hospital.DesignA qualitative, ethnographic approach was used to promote a comprehensive understanding of mealtime environment and practice.MethodsSixty‐seven hours of fieldwork was conducted August–October 2015. More than 150 participants were observed and 61 unique participants were interviewed in 75 interviews. Data analysis followed an inductive, thematic approach, informed by systems and complexity theory.FindingsThemes of “patient centredness” and “system” and their disharmonious interrelationship emerged. Staff, volunteers and visitors strive for patient centredness at mealtimes. The routine and structured nature of the meal and care systems was constantly in tension with providing patients the care they needed.ConclusionThe findings of this study expose the challenges associated with maintaining patient centredness at mealtimes in complex healthcare and foodservice systems. This facilitates a better understanding of why inadequate food intake is difficult to address in the hospital setting and highlights the need to support strategies that approach foodservice processes and nutritional care as complex and non‐linear.
Safety profiles of percutaneous left atrial appendage closure devices: An analysis of the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database from 2009 to 2016
Authors: Jazayeri Mohammad‐Ali , Vuddanda Venkat , Turagam Mohit K. , Parikh Valay , Lavu Madhav , Atkins Donita , Earnest Matthew , Di Biase Luigi , Natale Andrea , Wilber David , Reddy Yeruva Madhu , Lakkireddy Dhanunjaya R. 
Published: October 2017

AbstractBackgroundPercutaneous left atrial appendage closure (LAAC) is a viable option for AF patients who are unable to tolerate long‐term oral anticoagulation (OAC).ObjectiveWe sought to assess the safety of two commonly used percutaneous devices for LAA closure in the United States by analysis of surveillance data from the FDA Manufacturer and User Facility Device Experience (MAUDE) database.MethodsThe MAUDE database was queried between May 1, 2006 and May 1, 2016 for LARIAT® (SentreHEART Inc., Redwood City, CA, USA) and WATCHMAN™ (Boston Scientific Corp., Marlborough, MA, USA) devices. Among 622 retrieved medical device reports, 356 unique and relevant reports were analyzed. The cumulative incidence of safety events was calculated over the study period and compared between the two devices.ResultsLAAC was performed with LARIAT in 4,889 cases. WATCHMAN was implanted in 2,027 patients prior to FDA approval in March 2015 and 3,822 patients postapproval. The composite outcome of stroke/TIA, pericardiocentesis, cardiac surgery, and death occurred more frequently with WATCHMAN (cumulative incidence, 1.93% vs. 1.15%; P = 0.001). The same phenomenon was observed when comparing the WATCHMAN pre‐ and postapproval experiences for the composite outcome, as well as device embolization, cardiac surgery, and myocardial infarction.ConclusionsMAUDE‐reported data show that postapproval, new technology adoption is fraught with increased complications. Improved collaboration between operators, device manufacturers, and regulators can better serve patients through increased transparency and practical postmarket training and monitoring mechanisms.
How do Member States Return Unwanted Migrants? The Strategic (non‐)use of ‘Europe’ during the Migration Crisis
Authors: Slominski Peter , Trauner Florian 
Published: October 2017

AbstractThis article analyzes how Member States have used the opportunities and avoided the constraints of the EU's multilevel governance architecture to return unwanted migrants. Drawing on sociological approaches to the EU and a broad understanding of return policies, we investigate the ways in which the northern Member States, notably Germany and Austria, have increasingly relied upon the EU's operational and financial resources to achieve their goal of pursuing a bold return policy. A key ‘usage’ of Europe has been the pooling of political and financial power to externalize and informalize its return policy. At the same time, the northern Member States' deliberate – yet widely under‐researched – ‘non‐use’ of Europe, such as using and maximizing national leeway, has been an equally important strategy to reduce migratory pressure and achieve higher return rates.
Refugee Protection and Burden‐Sharing in the European Union
Authors: Bauböck Rainer 
Published: October 2017

AbstractThis article starts with discussing principles for a globally just system of refugee protection to which states contribute either by admitting refugees for resettlement or by supporting refugee integration in other states. Such a system requires relatively strong assurances of compliance by the states involved, which are absent in the international arena. In the European Union, however, the Member States form a predetermined set with prior commitments and supranational institutions that facilitate effective burden sharing. The article traces the failure of the EU's relocation scheme to meet this expectation to misconceptions how to determine fair shares, to incomplete prior harmonization of normative standards, and to contradictions between the Dublin Regulation's principle of assigning responsibility to first countries of entry, on the one hand, and the Schengen principle of open internal borders, on the other hand.
Backscattered electron imaging and electron backscattered diffraction in the study of bacterial attachment to titanium alloy structure
Authors: WANG ANQI , JONES IAN P. , LANDINI GABRIEL , MEI JUNFA , TSE YAU Y. , LI YUE X. , KE LINNAN , HUANG YUANLI , LIU LI , WANG CHUNREN , SAMMONS RACHEL L. 
Published: October 2017

SummaryThe application of secondary electron (SE) imaging, backscattered electron imaging (BSE) and electron backscattered diffraction (EBSD) was investigated in this work to study the bacterial adhesion and proliferation on a commercially pure titanium (cp Ti) and a Ti6Al4V alloy (Ti 64) with respect to substrate microstructure and chemical composition. Adherence of Gram‐positive Staphylococcus epidermidis 11047 and Streptococcus sanguinis GW2, and Gram‐negative Serratia sp. NCIMB 40259 and Escherichia coli 10418 was compared on cp Ti, Ti 64, pure aluminium (Al) and vanadium (V). The substrate microstructure and the bacterial distribution on these metals were characterised using SE, BSE and EBSD imaging. It was observed that titanium alloy‐phase structure, grain boundaries and grain orientation did not influence bacterial adherence or proliferation at microscale. Adherence of all four strains was similar on cp Ti and Ti 64 surfaces whilst inhibited on pure Al. This work establishes a nondestructive and straight‐forward statistical method to analyse the relationship between microbial distribution and metal alloy structure.
The structure of InAlGaN layers grown by metal organic vapour phase epitaxy: effects of threading dislocations and inversion domains from the GaN template
Authors: BEN AMMAR H. , MINJ A. , CHAUVAT M.‐P. , GAMARRA P. , LACAM C. , MORALES M. , RUTERANA P. 
Published: October 2017

SummaryDefects in quaternary InAlGaN barriers and their effects on crystalline quality and surface morphology have been studied. In addition to growth conditions, the quality of the GaN template may play an important role in the formation of defects in the barrier. Therefore, this work is focused on effects caused by threading dislocations (TDs) and inversion domains (IDs) originating from the underlying GaN. The effects are observed on the crystalline quality of the barrier and characteristic surface morphologies. Each type of TDs is shown to affect the surface morphology in a different way. Depending on the size of the corresponding hillock for a given pinhole, it was possible to determine the dislocation type. It is pointed out that the smallest pinholes are not connected to TDs whereas the large ones terminate either mixed type or edge type TDs. At sufficiently large layer thickness, the IDs originating from the GaN template lead to the formation of concentric trenches at the layer surface, and this is related to the change in growth kinetics on top and at the immediate surroundings of the ID.
Anatomy and development of the extrahepatic biliary system in mouse and rat: a perspective on the evolutionary loss of the gallbladder
Authors: Higashiyama Hiroki , Uemura Mami , Igarashi Hitomi , Kurohmaru Masamichi , Kanai‐Azuma Masami , Kanai Yoshiakira 
Published: October 2017

AbstractThe gallbladder is the hepatobiliary organ for storing and secreting bile fluid, and is a synapomorphy of extant vertebrates. However, this organ has been frequently lost in several lineages of birds and mammals, including rodents. Although it is known as the traditional problem, the differences in development between animals with and without gallbladders are not well understood. To address this research gap, we compared the anatomy and development of the hepatobiliary systems in mice (gallbladder is present) and rats (gallbladder is absent). Anatomically, almost all parts of the hepatobiliary system of rats are topographically the same as those of mice, but rats have lost the gallbladder and cystic duct completely. During morphogenesis, the gallbladder–cystic duct domain (Gb–Cd domain) and its primordium, the biliary bud, do not develop in the rat. In the early stages, SOX17, a master regulator of gallbladder formation, is positive in the murine biliary bud epithelium, as seen in other vertebrates with a gallbladder, but there is no SOX17‐positive domain in the rat hepatobiliary primordia. These findings suggest that the evolutionary loss of the Gb–Cd domain should be translated simply as the absence of a biliary bud at an early stage, which may correlate with alterations in regulatory genes, such as Sox17, in the rat. A SOX17‐positive biliary bud is clearly definable as a developmental module that may be involved in the frequent loss of gallbladder in mammals.
Influence of ration composition on nutritive and digestive variables in captive giraffes (Giraffa camelopardalis) indicating the appropriateness of feeding practice
Authors: Gussek I. , Große‐Brinkhaus C. , Südekum K.‐H. , Hummel J. 
Published: October 2017

SummaryThe nutrition of captive giraffe (Giraffa camelopardalis), a browsing ruminant, is challenging because browse availability is limited in zoos and rations need to be composed of compensatory feeds. In this study, ration composition for giraffes in 12 German zoos was documented and linked to animal variables that indicate suitability of nutrition. Rations differed in proportion of ration items and chemical composition resulting in various grades of accordance with feeding recommendations. An estimated daily metabolisable energy (ME) intake (MEI; mean ± SD) of 0.61 MJ ME/kg0.75 body weight (BW; ±0.1) was sufficient to cover estimated energy requirements. Daily dry matter (DM) intake (DMI) was 61 g DM/kg0.75 BW (±10) and correlated negatively to dietary ME content (p = .009; r = −.596). Apparently, feed intake was regulated by energetic satiety and not by physical properties of forage. A negative correlation between produce proportion and DMI (p = .002; r = −.676) led to the assumption of a low ruminal pH in giraffes fed high proportions of produce. Increasing dietary forage proportions led to an increasing duration of feed intake (p = .045; r = .477) and decreasing occurrence of oral stereotypies (p = .047; r = −.474). The weighted average faecal particle size was larger than reported for free‐ranging giraffes, but no relation to ration characteristics among the facilities existed. The abrasiveness of rations was not excessive, as contents of silicate in faeces were similar to values from the wild. Body condition was generally acceptable, but there was no evident relation to ration characteristics. The capacity to self‐regulate DM and ME intakes with lucerne hay may work at higher forage proportions than often assumed for captive giraffes. Rations with less energetic density can result in a greater DMI, including maximisation of forage intake and reduction of oral stereotypies.
Rural Disparities in Alzheimer's Disease‐Related Community Pharmacy Care in the United States
Authors: Henkel Paul Jacob , Marvanova Marketa 
Published: October 2017

AbstractPurposeTo examine the relationship between area population density and community pharmacy‐based Alzheimer's Disease (AD)‐related services: pharmacists’ medication knowledge and counseling, immunizations, and in‐stock cognitive enhancers in 3 predominantly rural regions of the United States.MethodsA standardized interview was administered by telephone to a 100% sample of community pharmacies in 3 areas: Northern California/Southern Oregon (n = 206), North and South Dakota (n = 278), and West Virginia (n = 420). Key study outcomes included: pharmacists’ medication knowledge, availability of immunization services, and cognitive enhancers in stock. Respondents were classified by population density (persons/mi2) by pharmacy location to evaluate the relationship between rurality and AD‐related pharmacy services. Chi‐squared and logistic regression analyses were performed using Stata 10.1.FindingsPharmacies in more rural areas (50.1‐100.0, 25.1‐50.0, and ≤25.0 persons/mi2) were about 50% less likely to offer immunizations (95% CI: 0.32‐0.91; 0.32‐0.76; 0.28‐0.80, respectively) compared to the least rural areas (>100.0 persons/mi2). Compared to the least rural areas, pharmacists in the most rural areas (≤25.0 persons/mi2) were less likely to name ≥2 gastrointestinal adverse effects of donepezil (OR = 0.50, 95% CI: 0.31‐0.82) or have memantine XR 28 mg (OR = 0.61, 95% CI: 0.41‐0.89) and other surveyed medications (OR = 0.57, 95% CI: 0.39‐0.82) in stock.ConclusionsWe found disparities in AD‐related services in community pharmacies located in more rural counties, wherein individuals with AD and their caregivers may face barriers to obtaining quality pharmaceutical care. There is a need to strengthen pharmacists’ knowledge and improve pharmacy services to reduce disparities.
The impact of sleep deprivation on visual perspective taking
Authors: Deliens Gaétane , Bukowski Henryk , Slama Hichem , Surtees Andrew , Cleeremans Axel , Samson Dana , Peigneux Philippe 
Published: October 2017

SummaryTotal sleep deprivation (TSD) is known to alter cognitive processes. Surprisingly little attention has been paid to its impact on social cognition. Here, we investigated whether TSD alters levels‐1 and ‐2 visual perspective‐taking abilities, i.e. the capacity to infer (a) what can be seen and (b) how it is seen from another person's visual perspective, respectively. Participants completed levels‐1 and ‐2 visual perspective‐taking tasks after a night of sleep and after a night of TSD. In these tasks, participants had to take their own (self trials) or someone else's (other trials) visual perspective in trials where both perspectives were either the same (consistent trials) or different (inconsistent trials). An instruction preceding each trial indicated the perspective to take (i.e. the relevant perspective). Results show that TSD globally deteriorates social performance. In the level‐1 task, TSD affects the selection of relevant over irrelevant perspectives. In the level‐2 task, the effect of TSD cannot be unequivocally explained. This implies that visual perspective taking should be viewed as partially state‐dependent, rather than a wholly static trait‐like characteristic.
Commissioning guidance for weight assessment and management in adults and children with severe complex obesity
Authors: Welbourn R. , Hopkins J. , Dixon J. B. , Finer N. , Hughes C. , Viner R. , Wass J. ,   on behalf of the Guidance Development Group
Published: October 2017

SummaryThe challenge of managing the epidemic of patients with severe and complex obesity disease in secondary care is largely unmet. In England, the National Institute of Health and Care Excellence and the National Health Service England have published guidance on the provision of specialist (non‐surgical) weight management services. We have undertaken a systematic review of ‘what evidence exists for what should happen in/commissioning of: primary or secondary care weight assessment and management clinics in patients needing specialist care for severe and complex obesity?’ using an accredited methodology to produce a model for organization of multidisciplinary team clinics that could be developed in every healthcare system, as an update to a previous review. Additions to the previous guidance were multidisciplinary team pathways for children/adolescent patients and their transition to adult care, anaesthetic assessment and recommendations for ongoing shared care with general practitioners, as a chronic disease management pathway.