bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supramolecular Porphyrin Photosensitizers Based on Host−Guest Recognition for In Situ Bacteria‐Responsive Near‐Infrared Photothermal Therapy
Authors: Wu Dan , Du Xianlong , Xue Qiangqiang , Zhou Jie , Ping Kunmin , Cao Yibin , Liu Shuang , Zhu Qing 
Published: October 2024

AbstractAntibiotic resistance resulting from the overuse of antibiotics sets a high challenge for brutal antimicrobial treatment. Although photothermal therapy (PTT) overcomes the awkward situation of antibiotic resistance, it usually mistakenly kills the beneficial bacteria strains when eliminating pernicious bacteria. Specifically recognizing and damaging the target pathogens is urgently required for PTT‐mediated sterilization strategy. Based on the host–guest recognition between cucurbit[10]uril (CB[10]) and porphyrins, two water‐soluble supramolecular porphyrins are designed and implement selective bactericidal effect via in situ bacteria‐responsive near‐infrared (NIR) PTT. With the help of CB[10], the π–π stacking and hydrophobic interactions of porphyrins are efficiently inhibited, thus contributing to a good photostability and a high photothermal conversion efficiency. Attributing to the matching reduction potential between facultative anaerobic Escherichia coli (E. coli) and porphyrins, they are selectively in situ reduced into supramolecular phlorin and supramolecular chlorin by E. coli, successfully achieving a selective sterilization against E. coli. In vivo, the in situ bacteria‐responsive NIR PTT systems also promote the quick recovery of E. coli‐infected abscesses and trauma on mice without inducing obvious systemic toxicity, providing a new alternative to the current antibiotics and helping relieve the global public health crisis of abusive antibiotics.
Tailoring Ultra‐Narrowband Tetraborylated Multiple Resonance Emitter for High‐Performance Blue OLED
Authors: Yuan Wenbo , Jin Qian , Du Mingxu , Duan Lian , Zhang Yuewei 
Published: October 2024

AbstractUltra‐narrowband multiple resonance (MR) emitters are a key component in the fabrication of highly efficient and stable blue organic light‐emitting diodes (OLEDs). To explore the theoretical boundaries of wavelength and full width at half maximum (FWHM) in blue emitters, the currently narrowest boron‐based MR emitter is carefully designed by integrating the superior v‐DABNA and BBCz‐DB structures under the auspices of the ingenious short‐range charge‐transfer region regulation strategy. The target tetraboron compound TB‐PB demonstrates a blue emission with an emission maximum of 473 nm, a small FWHM of 12 nm and a CIEy coordinate of 0.14. Benefiting from the emitter's high photoluminescence quantum yield (99%), low excited‐state energy (2.74 eV) and short delayed fluorescence lifetime (0.53 µs), the corresponding OLED achieves exceptional efficiencies of 36.4%, 49.1 cd A−1, and 51.4 lm W−1 with a record‐high luminescence of 9.0 × 105 cd m−2, an ultra‐narrow FWHM of 15 nm and a CIEy coordinate of 0.20. These breakthroughs will accelerate the development of next‐generation blue emitters and lead to the advancement of OLED technology.
Domain Dynamics Response to Polarization Switching in Relaxor Ferroelectrics
Authors: Li Yang , Lin Wei , Wang Cong , Zhang Shumin , He Yunfei , Gao Weibo , Zhao Shifeng 
Published: October 2024

AbstractNanoscale polar regions, or nanodomains (NDs), are crucial for understanding the domain structure and high susceptibility of relaxors. However, unveiling the evolution and function of NDs during polarization switching at the microscopic level is of great challenge. The experimental in situ characterization of NDs under electric‐field perturbations, and computational accurate prediction of the dipole switching within a sufficiently large supercell, are notoriously tricky and tedious. These difficulties hinder a full understanding of the link between micro domain dynamics and macro polarization switching. Herein, the real‐time evolution of NDs at the nanoscale is observed and visualized during polarization switching in an exemplary relaxor system of Bi5‐xLaxMg0.5Ti3.5O15. Two fundamentally different domain switching pathways and dynamic characteristics are revealed: one steep, bipolar‐like switching between two degenerate polarization states; and another flat, multi‐step switching process with a thermodynamically stable non‐polar mesophase mediating the degenerate polarization states. The two are determined by the distinct Landau energy landscapes that are strongly dependent on the intrinsic domain configurations and interdomain interactions. This work bridges the gap between micro domain dynamics and macro polarization switching, providing a guiding principle for the strategic design and optimization of relaxors.
Deconvoluting Effects of Lithium Morphology and SEI Stability at Moderate Current Density Using Interface Engineering
Authors: Shuchi Sanzeeda Baig , Oyakhire Solomon T. , Zhang Wenbo , Sayavong Philaphon , Ye Yusheng , Chen Yuelang , Yu Zhiao , Cui Yi , Bent Stacey F. 
Published: October 2024

AbstractLithium (Li)‐morphology and solid electrolyte interphase (SEI) are among the most significant performance regulators in Li‐metal batteries (LMBs). While both Li‐morphology and SEI composition play key roles in the cyclability of LMBs, less is understood about the individual contributions of each factor to overall Li reversibility, particularly at a practical current density (1 mA cm−2) at which the kinetics of both factors are not naturally separated. Herein, an interface engineering approach is introduced to deconvolute the impacts of Li‐morphology and SEI composition on battery performance. By using interfacial nanofilms with differing resistivity (resistive HfO2 versus conductive ZnO), the morphology of Li is varied, and by virtue of similar acidic character of the nanofilms, the formation of anion‐rich SEIs is maintained. It is established that although the surface acidity of the thin films enables preformation of a more anion‐rich SEI, it is not preserved after Li plating. It is further shown that resistance‐controlled, low‐surface‐area Li‐morphology exhibits up to threefold increase in stable cycle life when tested in multiple electrolytes. Overall, these findings explain why Li‐morphological control is more advantageous for performance improvement than preformed SEI modulation due to the inherent challenges in SEI preservation.
Diaryliodonium Salt‐Mediated Radical Transformation of Indoles with Alcohols for the Synthesis of Unsymmetrical Bis(indolyl)methanes
Authors: Wang Hongzhen , Jiang Haohao , Lin Shuizhen , Zhang Shuoshuo , Huang Xiaolei 
Published: October 2024

AbstractA method for the synthesis of unsymmetrical bis(indolyl)methanes (BIMs) using simple indoles and readily available alcohols as the coupling partners under both heat and 390–400 nm light conditions was developed. Detailed research of the mechanism demonstrated that the diaryliodonium salt‐mediated transformation undergoes a nucleophilic hydroxymethyl radical formation process. Moreover, the diaryliodonium salt‐mediated method is also applicable for synthesizing symmetrical BIMs.
Targeting KIFC1 Promotes Senescence in Soft Tissue Sarcoma via FXR1‐Dependent Regulation of MAD2L1 mRNA Stability
Authors: Lu Xiu‐Xia , Que Yi , Yang Jing , Le Li‐Yuan , Cai Qi‐Yan , Xu Bu‐Shu , Hong Dong‐Chun , Liang Yao , Zhang Xing 
Published: October 2024

AbstractPatients diagnosed with soft tissue sarcoma (STS) often present at intermediate to advanced stages, with inherently limited therapeutic options available. There is an urgent need to identify novel therapeutic targets. In this study, by screening STS data from the Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) databases, KIFC1 is identified as a potential biomarker and a promising therapeutic target for STS. Notably, a significant increase in KIFC1 levels, which exhibited a strong correlation with a poor prognosis in STS patients is observed. The findings revealed that knockout of KIFC1 suppressed STS growth both in vitro and in vivo. Furthermore, KIFC1 is found to regulate cellular senescence in STS, which has not been reported before. that targeting KIFC1 induced cellular senescence via interacting with FXR1, an RNA‐binding protein is discovered, thereby further stabilizing MAD2L1 mRNA in an m6A‐dependent manner. Additionally, the suppression of KIFC1 markedly diminished the growth of patient‐derived xenografts (PDX) and triggered senescence. This study provides the first evidence that KIFC1 inhibition induces cellular senescence through MAD2L1, underscoring KIFC1 as a novel prognostic biomarker and a potential therapeutic target for STS.
Insights into the Biological Activity and Bio‐Interaction Properties of Nanoscale Imine‐Based 2D and 3D Covalent Organic Frameworks
Authors: Ye Hao , Franco Carlos , Aboouf Mostafa A. , Thiersch Markus , Sevim Semih , Llacer‐Wintle Joaquin , Veciana Andrea , Llauradó‐Capdevila Gemma , Wang Kaiyuan , Chen Xiang‐Zhong , Tang Qiao , Matheu Roc , Wendel‐Garcia Pedro D. , Sánchez‐Murcia Pedro A. , Nelson Bradley J. , Luo Cong , Puigmartí‐Luis Josep , Pané Salvador 
Published: October 2024

AbstractCovalent Organic Frameworks (COFs) emerged as versatile materials with promising potential in biomedicine. Their customizable functionalities and tunable pore structures make them valuable for various biomedical applications such as biosensing, bioimaging, antimicrobial activity, and targeted drug delivery. Despite efforts made to create nanoscale COFs (nCOFs) to enhance their interaction with biological systems, a comprehensive understanding of their inherent biological activities remains a significant challenge. In this study, a thorough investigation is conducted into the biocompatibility and anti‐neoplastic properties of two distinct imine‐based nCOFs. The approach involved an in‐depth analysis of these nCOFs through in vitro experiments with various cell types and in vivo assessments using murine models. These findings revealed significant cytotoxic effects on tumor cells. Moreover, the activation of multiple cellular death pathways, including apoptosis, necroptosis, and ferroptosis is determined, supported by evidence at the molecular level. In vivo evaluations exhibited marked inhibition of tumor growth, associated with the elevated spontaneous accumulation of nCOFs in tumor tissues and the modulation of cell death‐related protein expression. The research contributes to developing a roadmap for the characterization of the intricate interactions between nCOFs and biological systems and opens new avenues for exploiting their therapeutic potential in advanced biomedical applications.
Combination of AMMI, GGE biplot, stability parameters, and physiological traits in promising barley genotypes under water‐deficit condition
Authors: Saidi Abbas , Barati Ali , Ghazvini Habibollah , Hajibarat Zohreh 
Published: October 2024

AbstractSuccessful improvement of stable genotypes is dependent on the interaction of genotype with environment, which has a great influence on breeding new barley (Hordeum vulgare) varieties. The main objectives of this study were to (1) evaluate the effectiveness of drought tolerance indices for the selection of drought‐tolerant barley genotypes, (2) identify stable high‐yielding genotypes in variable environments, and (3) survey physiological traits of five contrasting genotypes under water deficit. In this experiment, 18 spring barley genotypes were evaluated under two moisture regimes (normal and deficit irrigations) for 2 years during the crop periods of 2022–2023 in Varamin Agriculture Experimental Station. In order to identify drought‐tolerant barley genotypes in response to water deficit, GGE (genotype and genotype by environment interaction) biplot and AMMI (additive main effects and multiplicative interaction) analysis, stability parameters, and drought indices under water deficit and normal condition were used. Also, physiological traits in three tissues (leaf, penultimate, and peduncle) were measured. Based on our results, AMMI and GGE biplot analysis revealed that the G15 genotype was superior to other genotypes under water‐deficit condition. Based on the physiological traits, the G3 and G15 had higher chlorophyll content and carotenoids than other genotypes under water deficit as compared to normal condition. Our results demonstrate the efficiency of the stability evaluation techniques to select genotypes that are high‐yielding and responsive to drought stress condition.
Valorization of Mexican cabernet sauvignon grape pomace: A source of oil and lipophilic bioactive compounds
Authors: Leon‐Bejarano Marcos , Ovando‐Martínez Maribel , Simsek Senay 
Published: October 2024

AbstractThis study presents the first analysis of the lipophilic composition of oil extracted from Mexican Cabernet sauvignon grape pomace in Sonora, using ultrasound‐assisted extraction. The findings reveal a promising oil yield of 7.52%, with linoleic acid dominating the fatty acid profile at 64.72%. Notably, the oil is rich in bioactive compounds, including tocopherols‐tocotrienols (828.83 mg/kg), chlorophylls (32.15 mg/kg), carotenoids (550.04 mg/kg), and sterols (513265.51 mg/kg), highlighting its potential for valorization. These components are recognized for their biological potential, suggesting the grape pomace as a valuable source of high‐value lipophilic compounds. This research contributes to the growing interest in utilizing wine industry by‐products, advocating for further exploration of grape pomace's applications in food, cosmetics, and pharmaceuticals, thereby supporting sustainable practices in the agricultural sector.
The combustion mechanism of aluminium in the steam/carbon dioxide mixed atmosphere
Authors: Qian Xiaoyan , Ji Yanwu , Wang Jiquan , Zhu Baozhong , Xu Minggao , Sun Yunlan 
Published: October 2024

AbstractThe ignition and combustion characteristics of aluminium (Al) in the steam/carbon dioxide (H2O/CO2) mixed atmosphere were calculated by using a close homogeneous catch reactor and premixed laminar flame‐speed of CHEMKIN‐PRO. The effects of initial reaction temperature and H2O/CO2 ratios on the system temperature, products, and ignition delay time were explored. The main reaction paths were analyzed by the temperature sensitivity. Al (l) entered the system with a pronounced phase transition and only one heating stage, but there are two heating stages in the Al (g) system. The reaction of Al in the H2O/CO2 mixed atmosphere has a positive effect on the ignition delay time of the system. The high contents of CO2 in the H2O/CO2 mixed atmosphere can increase the maximum temperature of system and decrease the ignition delay time. Temperature sensitivity analysis shows that AlO, Al2O, and AlOH are important intermediate products, and Al2O2 is the main substance that produces Al2O3. The dominant reaction path is Al → AlOH→AlO → Al2O → Al2O2 → Al2O3. In addition, when the initial temperature was 2300 K, the laminar flame velocity was calculated to reach 35.6 m/s.
Mild behavioral impairment in the general population aged 55+ and its association with incident dementia
Authors: Gracia‐García Patricia , López‐Antón Raúl , de la Cámara Concepción , Santabárbara Javier , Lobo Elena , Lobo Antonio 
Published: October 2024

AbstractThis study aimed to investigate the dementia risk associated with mild behavioral impairment (MBI) and its domains in older community‐dwelling individuals. A total 4803 community‐dwelling individuals aged over 55 years were followed for 4.5 years (ZARADEMP study). MBI was assessed according to the International Society to Advance Alzheimer's Research and Treatment (ISTAART) diagnostic criteria using the Geriatric Mental State (GMS). Odds ratios (OR) for incident dementia and Alzheimer's disease (AD) were determined using logistic regression models adjusted for potential confounders (such as age, disability, or vascular disease). In cognitively normal individuals, decreased motivation was the only MBI domain that was associated with an increased risk of all‐cause dementia (OR: 2.30 [95% confidence interval {CI}: 1.16‐4.61]) in multivariable analyses, although the increase in the risk of AD was not statistically significant. Our findings suggest that decreased motivation may be a phenotypic marker for individuals at risk of dementia. Further research is required to evaluate the association between MBI domains and different types of dementia.
Hospital admissions for dementia in the Brazilian public health system over the last decade
Authors: Justo Alberto Fernando Oliveira , Gonçalves Natalia Gomes , Santos Adriana Nancy Medeiros Dos , Paradela Regina Silva , Aliberti Márlon Juliano Romero , Ferri Cleusa Pinheiro , Suemoto Claudia Kimie 
Published: October 2024

AbstractOBJECTIVEThe rise in dementia prevalence, particularly in lower‐ and middle‐income countries (LMIC), places a significant burden on healthcare systems. However, comprehensive data on dementia hospital admissions are scarce.METHODSWe analyzed admission rates for dementia, cost of hospital admissions, lengths of hospital stay, and in‐hospital deaths in 2010 and 2019 in Brazil.RESULTSAdmission rates declined from 19.7/100,000 inhabitants in 2010 to 14.6/100,000 in 2019. In‐hospital mortality increased from 3.9% in 2010 to 8.8% in 2019, particularly for short‐term stays. Although 9.6% of hospital admissions occurred in regions with lower economic power in 2010 and 10.4% in 2019, these regions had higher mortality, reaching 4.3% of in‐hospital deaths in 2010 and 9.3% in 2019.CONCLUSIONThe observed trends, alongside sex and regional disparities, underscore the need for targeted investment in healthcare infrastructure and training to improve dementia care in LMIC.Highlights
The rate of hospital admissions for dementia was similar in 2010 and 2019 in Brazil.
The cost per hospital admission in 2010 decreased by 38.5% compared with 2019.
There was an increase in short‐term hospital stays for dementia in 2019 compared to 2010, accompanied by an increase in mortality rates for these short‐term stays.
While hospital admissions for dementia decreased in men and increased in women, the in‐hospital mortality due to dementia increased for both sexes.
Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment
Authors: Opwonya Julius , Kim Kahye , Lee Kun Ho , Kim Joong Il , Kim Jaeuk U. 
Published: October 2024

AbstractINTRODUCTIONEye movement alterations are effective biomarkers for Alzheimer's disease (AD). This study examines task‐evoked pupillary responses (TEPRs) as potential biomarkers of the mild cognitive impairment (MCI), the symptomatic stage preceding AD.METHODSThe prospective cohort study included 213 MCI patients and 514 cognitively normal controls (CNs). Participants performed a prosaccade (PS) or antisaccade (AS) task while their eye movements were tracked using a Tobii Pro Spectrum system.RESULTSThe CNs showed unique TEPRs linked to better performance, characterized by larger baselines, greater PS target‐onset variability, and smaller AS target‐onset variability. Conversely, for MCI patients, better performance was linked to larger AS target‐onset sizes. Furthermore, MCI patients displayed reduced dilation during the cue and target‐onset periods compared to CNs.DISCUSSIONMCI patients showed altered pupillary response patterns associated with cognitive task performance, highlighting the potential of oculomotor changes as a biomarker for early cognitive decline.Highlights
MCI patients displayed markedly smaller pupil dilation than CNs in response to cue and target stimuli.
For MCI patients, larger pupil size upon target appearance during antisaccades correlated with better performance.
Faster and more consistent prosaccades were linked to better performance in both groups.
For MCI patients, the association between longer AS latencies and better performance was more pronounced than in CNs.
Combined analysis of TEPRs and saccade performances in a sizeable cohort strengthens the generalizability of our findings to the broader MCI population.
Linking resource selection to population performance spatially to identify species' habitat across broad scales: An example of greater sage‐grouse in a distinct population segment
Authors: Milligan Megan C. , Coates Peter S. , Brussee Brianne E. , O'Neil Shawn T. , Mathews Steven R. , Espinosa Shawn P. , Miller Katherine , Skalos Daniel , Wiechman Lief A. , Abele Steve , Boone John , Boatner Kristie , Stone Heather , Casazza Michael L. 
Published: October 2024

AbstractManagement decisions often focus on the habitat selection of marked individuals without considering the contribution to demographic performance in selected habitats. Because habitat selection is not always adaptive, understanding the spatial relationship between habitat selection and demographic performance is critical to management decisions. Mapping both habitat selection and demographic performance for species of conservation concern can help guide population‐scale conservation efforts. We demonstrate a quantitative approach to differentiate areas supporting selection and survival at large spatial extents. As a case study, we applied this approach to greater sage‐grouse (Centrocercus urophasianus; hereafter, sage‐grouse), an indicator species for sagebrush ecosystems. We evaluated both habitat selection and survival across multiple reproductive life stages (nesting, brood‐rearing) in the Bi‐State Distinct Population Segment, a genetically distinct and geographically isolated population of sage‐grouse on the southwestern edge of the species' range. Our approach allowed us to identify both mismatches between selection and survival and trade‐offs between reproductive life stages. These findings suggest resource demands vary across time, with predation risk being a dominant driver of habitat selection during nesting and early brood‐rearing periods when chicks are smaller and flightless, whereas access to forage resources becomes more important during late brood rearing when resources become increasingly limited. Moving beyond identifying and managing habitat solely based on species occupancy or use by incorporating demographic measures allows managers to tailor actions to their specific goals; for example, protections of areas that support high selection and high survival and restoration actions focused on increasing survival in areas of high selection and low survival.