bluuebunny/crossref_metadata_2025_split huggingface dataset:
The number of CD56dim NK cells in the graft has a major impact on risk of disease relapse following allo-HSCT
Authors: Maggs Luke , Kinsella Francesca , Chan Y. L. Tracey , Eldershaw Suzy , Murray Duncan , Nunnick Jane , Bird Joanne , Craddock Charles , Zuo Jianmin , Malladi Ram , Moss Paul 
Published: August 2017

Key Points
A stem cell graft NK cell dose below 6.3 × 106 cells per kg associates with risk of disease relapse following T-cell–depleted allo-HSCT. Clinical outcomes of patients undergoing allo-HSCT may be improved by setting an NK cell threshold within donor stem cell grafts.
Dynamic Specification of Initial Structures in Parallel Cascade Selection Molecular Dynamics (PaCS-MD) Efficiently Promotes Biologically Relevant Rare Events
Authors: Harada Ryuhei , Shigeta Yasuteru 
Published: August 2017

Abstract
Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is an enhanced conformational sampling method for generating structural transition pathways between a given reactant and a product. To promote structural transitions from the reactant to the product, PaCS-MD repeats cycles of conformational resampling of (1) reasonable initial structures and (2) short-time MD simulations restarting the structures with renewed velocities. Appropriately setting a number of these initial structures is essential for efficient PaCS-MD.
We propose a novel, optimal algorithm for specifying suitable initial structures, ninitial, to find structural transitions; this is referred to as dn-PaCS-MD. PaCS-MD typically has a fixed ninitial, while in dn-PaCS-MD it is dynamically reset according to a minimum root mean square deviation (RMSD), defined as an RMSD derivative. dn-PaCS-MD, with the dynamic ninitial accelerates structural transitions to the product, compared to the original PaCS-MD with the fixed ninitial, as confirmed in Chignolin protein-folding. This algorithm was also applied to Human-β-defensin 2, whose X-ray and NMR structures differ in the N-terminal region. Finally, we compared forward and backward transition pathways from the former to the latter generated by our method, and estimated a free energy barrier between them, creating new possibilities to visualize the NMR and X-ray structures in solution.
Synthesis of Cyclic Oligomers of 4,4′′-Diethynyl-4′,5′-dioctyl-o-terphenyl Using Eglington Coupling Reaction: Formation of Large Cyclic Oligomers as Major Products under Standard Conditions
Authors: Sako Ikumi , Kishimoto Naoki , Otani Hiroyuki , Nishiuchi Tomohiko , Shimizu Hideyuki , Iyoda Masahiko 
Published: August 2017

Abstract
Dimer 2, trimer 3, hexamer 6, octamer 8, and decamer 10 of 4,4′′-diethynyl-4′,5′-dioctyl-o-terphenyl 1 were synthesized by using copper(II) acetate-mediated Eglington coupling reaction of 1 in pyridine or pyridine–methanol. Although dimer 2 and trimer 3 were formed as major products under high dilution conditions, large oligomers such as hexamer 6, octamer 8, and decamer 10 were obtained in moderate total yield under standard Eglington conditions. The MALDI-TOF MS and GPC behavior of large oligomers exhibit the formation of giant macrocycles 3 nm diameter and 2–4 nm long in one-pot procedure.
Fabrication and Operation of Monolayer Mott FET at Room Temperature
Authors: Yang Fan , Suda Masayuki , Yamamoto Hiroshi M 
Published: August 2017

Abstract
Self-assembled monolayer FET based on a TTF derivative is described (FET = field-effect-transistor, TTF = tetrathiafulvalene). The molecule is anchored on an alumina dielectric layer through covalent bonding of a phosphonic acid linker. A p-type monolayer FET device is achieved and subsequent chemical doping of this monolayer with F4TCNQ dopants results in an ambipolar device. (F4TCNQ = 2,3,5,6-Tetrafluoro-7,7,8,8-tetracyanoquinodimethane) Several strange behaviors including a gate voltage shift upon doping seem to be consistent with organic monolayer Mott FET. Finally, temperature dependence of the FET performance, which also fit the anticipated Mott FET behavior, is discussed.
Renal impairment in stroke patients: A comparison between the haemorrhagic and ischemic variants
Authors: Shrestha Pratyush , Thapa Shalima , Shrestha Shikher , Lohani Subash , BK Suresh , MacCormac Oscar , Thapa Lekhjung , Devkota Upendra Prasad 
Published: August 2017

Background: Renal impairment is regularly seen in hospitalized stroke patients, affecting the outcome of patients, as well as causing difficulties in their management. A prospective cohort study was conducted to assess the trend of renal function in hospitalized ischemic and haemorrhagic stroke patients. The incidence of renal impairment in these subgroups, the contributing factors and the need for renal replacement in renal impaired patients was evaluated. Methods: Alternate day renal function testing was performed in hospitalized stroke patients. Estimated glomerular filtration rate (e-GFR) was calculated and the trend of renal function in the two stroke subgroups (haemorrhagic and ischemic) was assessed, with renal impairment defined as e-GFR < 60mL/ minute per 1.73m2. Results: Among 52 patients, 25 had haemorrhagic stroke (mean age 59.81 ± 14.67) and 27 had ischemic stroke (mean age 56.12 ± 13.08). The mean e-GFR (mL/minute per 1.732m2) at admission in the haemorrhagic stroke subgroup was 64.79 ± 25.85 compared to 86.04 ± 26.09 in the ischemic stroke subgroup (p=0.005). Sixteen out of 25 (64%) patients in the haemorrhagic stroke subgroup and 9 out of 27 (33.3%) patients in the ischemic subgroup developed renal impairment (p=0.27). The location of the bleed (p=0.8), volume of hematoma (p=0.966) and surgical intervention (p=0.4) did not predispose the patients to renal impairment. One out of 16 patients with haemorrhagic stroke (who eventually died), and 2 out of 9 patients with ischemic stroke required renal replacement. Conclusion: Renal impairment is commonly seen in stroke patients, more so in patients who suffered haemorrhagic strokes. The impairment, however, is transient and rarely requires renal replacement therapy.
Identification of the ventral occipital visual field maps in the human brain
Authors: Winawer Jonathan , Witthoft Nathan 
Published: August 2017

The location and topography of the first three visual field maps in the human brain, V1-V3, are well agreed upon and routinely measured across most laboratories. The position of 4th visual field map, ‘hV4’, is identified with less consistency in the neuroimaging literature. Using magnetic resonance imaging data, we describe landmarks to help identify the position and borders of ‘hV4’. The data consist of anatomical images, visualized as cortical meshes to highlight the sulcal and gyral patterns, and functional data obtained from retinotopic mapping experiments, visualized as eccentricity and angle maps on the cortical surface. Several features of the functional and anatomical data can be found across nearly all subjects and are helpful for identifying the location and extent of the hV4 map. The medial border of hV4 is shared with the posterior, ventral portion of V3, and is marked by a retinotopic representation of the upper vertical meridian. The anterior border of hV4 is shared with the VO-1 map, and falls on a retinotopic representation of the peripheral visual field, usually coincident with the posterior transverse collateral sulcus. The ventro-lateral edge of the map typically falls on the inferior occipital gyrus, where functional MRI artifacts often obscure the retinotopic data. Finally, we demonstrate the continuity of retinotopic parameters between hV4 and its neighbors; hV4 and V3v contain iso-eccentricity lines in register, whereas hV4 and VO-1 contain iso-polar angle lines in register. Together, the multiple constraints allow for a consistent identification of the hV4 map across most human subjects.
Dynamic Learning of Patient Response Types: An Application to Treating Chronic Diseases
Authors: Negoescu Diana M. , Bimpikis Kostas , Brandeau Margaret L. , Iancu Dan A. 
Published: August 2017

Currently available medication for treating many chronic diseases is often effective only for a subgroup of patients, and biomarkers accurately assessing whether an individual belongs to this subgroup typically do not exist. In such settings, physicians learn about the effectiveness of a drug primarily through experimentation—i.e., by initiating treatment and monitoring the patient’s response. Precise guidelines for discontinuing treatment are often lacking or left entirely to the physician’s discretion. We introduce a framework for developing adaptive, personalized treatments for such chronic diseases. Our model is based on a continuous-time, multi-armed bandit setting where drug effectiveness is assessed by aggregating information from several channels: by continuously monitoring the state of the patient, but also by (not) observing the occurrence of particular infrequent health events, such as relapses or disease flare-ups. Recognizing that the timing and severity of such events provide critical information for treatment decisions is a key point of departure in our framework compared with typical (bandit) models used in healthcare. We show that the model can be analyzed in closed form for several settings of interest, resulting in optimal policies that are intuitive and may have practical appeal. We illustrate the effectiveness of the methodology by developing a set of efficient treatment policies for multiple sclerosis, which we then use to benchmark several existing treatment guidelines.The online appendix is available at https://doi.org/10.1287/mnsc.2017.2793 .This paper was accepted by Noah Gans, stochastic models and simulation.
Gift Exchange in the Workplace: Addressing the Conflicting Evidence with a Careful Test
Authors: Esteves-Sorenson Constança 
Published: August 2017

Tests of gift exchange, wherein agents receive excess wages which are noncontingent on performance in one-shot settings, have yielded contradictory evidence: they sometimes find effort boosts, consistent with gift exchange, whereas they sometimes find no effort increases, consistent with a standard model. We identify eight confounds that could have led to the mixed evidence—agent disutility from being viewed as selfish, small samples, insufficient wage raises, an effort ceiling, fatigue, selection of abler workers, reemployment concerns, and peer effects—and run a comprehensive test addressing them. Our test consisted of a field experiment hiring workers for a data entry job, followed by laboratory games assessing their prosocial behavior. After addressing these confounds, we find that behavior during the field test was consistent with a standard model: workers did not repay fixed wage raises with an effort boost, but they did raise effort in response to a piece rate. The piece-rate scheme was also more efficient: the effort boost came at lower expense than paying fixed wage raises. Further, workers who behaved prosocially in laboratory games did not behave prosocially in the field. Data and the online appendix are available at https://doi.org/10.1287/mnsc.2017.2801. . This paper was accepted by John List, behavioral economics.
Monitoring content of cadmium, calcium, copper, iron, lead, magnesium and manganese in tea leaves by electrothermal and flame atomizer atomic absorption spectrometry
Authors: Prkić Ante , Jurić Antonija , Giljanović Josipa , Politeo Nives , Sokol Vesna , Bošković Perica , Brkljača Mia , Stipišić Angela , Fernandez Carlos , Vukušić Tina 
Published: August 2017

AbstractDue to the simplicity of tea preparation (pouring hot water onto different dried herbs) and its high popularity as a beverage, monitoring and developing a screening methodology for detecting the metal content is very important. The concentrations of Cd, Ca, Cu, Fe, Pb, Mg and Mn in 11 different samples of sage (Salvia officinalis L.), linden (Tilia L.) and chamomile (Matricaria chamomilla L.) purchased at local herbal pharmacy were determined using electrothermal atomizer atomic absorption spectrometry (ETAAS) and flame atomizer atomic absorption spectrometry (FAAS). The concentrations determined were: Cd (0.012 – 0.470 mg kg−1), Ca (5209 – 16340 mg kg−1), Cu (22.01 – 33.05 mg kg−1), Fe (114.2 – 440.3 mg kg−1), Pb (0.545 – 2.538 mg kg−1), Mg (2649 – 4325 mg kg−1) and Mn (34.00 – 189.6 mg kg−1). Principal Component Analysis (PCA) was applied to identify factors (soil and climate) influencing the content of the measured elements in herbal samples. The proposed methodology developed in this work was successfully applied to the detection of metals in herbal samples. The analysis showed that the content of toxic metals in herbal teas was below the maximum dose recommended by the World Health Organization (WHO).
Mediated characters: Multimodal viewpoint construction in comics
Authors: Borkent Mike 
Published: August 2017

AbstractI analyze multimodal viewpoint construction in comics to engage with how modalities function within the medium as a specific discourse context with distinct conventions and material qualities. I show how comics employ established storytelling practices with character, narrator, and narrative viewpoint levels, while building up and interweaving these through strategic uses of the modalities of the medium. I mobilize the cognitive theories of embodiment, domains, mental simulation, and mental space blending as an analytical framework. I examine the asynchronicity of viewpoint elements between modalities and their synthesis into composite character viewpoints in several examples. I show how modalities can be prioritized and their different qualities and functions strategically manipulated for viewpoint construal. These brief examples show the complexity inherent in multimodal communication and interpretation and the usefulness of encouraging the medium-specific and interdisciplinary analyses of cultural works from a cognitive linguistic perspective.
Internet memes as multimodal constructions
Authors: Dancygier Barbara , Vandelanotte Lieven 
Published: August 2017

AbstractThis paper considers a range of so-called image macro Internet memes and describes them as emerging multimodal constructions relying as much on image as on text, and apportioning roles to images much like constructional slots, for instance to fill in a subject role in a subjectless clause, or even to provide the main clause content to a textually givenwhen-clause. In addition to existing or partially altered linguistic constructions, many examples also rely on specific top text/bottom text division of labor, and crucially depend on frame metonymy, with limited formal means quickly cueing richly detailed frames (for instance by using iconic images). The popularity of memes, forming series and cycles of iterations and remixes, and their role in establishing and maintaining discourse communities seems to be driven by a need to express and reconstrue viewpoints, often starting from ideas, affects or stereotypes assumed to be intersubjectively shared with viewers, whose responses they solicit. This paper argues that a proper description of Internet memes of the type considered requires a construction grammar approach, complemented by an understanding of viewpoint dynamics in terms of a Discourse Viewpoint Space regulating the network of spaces and viewpoints.
Independence numbers of random sparse hypergraphs
Authors: Semenov Aleksandr S. , Shabanov Dmitriy. A. 
Published: August 2017

Abstract
The paper is concerned with the asymptotic behaviour of the independence number for the binomial model of a random k-regular hypergraph H(n, k, p) in a sparse case, when

p
=
c

/

n
−
1

k
−
1

$p=c/{n-1\choose k-1}$

with positive constant c > 0. The independence number α(H(n, k, p)) is shown to satisfy the law of large numbers

α
(
H
(
n
,
k
,
p
)
)

n

→

P

γ
(
c
)

as
n
→
+
∞

$$\frac{\alpha(H(n,k,p))}{n}\stackrel{{\sf P}}{\to}\gamma(c)\;\;\mbox{ as }n\to+\infty$$

with some constant γ(c) > 0. We also shows that γ (c) > 0 is a solution of some transcendental equation for small values of c ⩽ (k - 1)-1.
Influence of Social-economic Activities on Air Pollutants in Beijing, China
Authors: Li Xiaolu , Zheng Wenfeng , Yin Lirong , Yin Zhengtong , Song Lihong , Tian Xia 
Published: August 2017

AbstractWith the rapid economic development, the serious air pollution in Beijing attracts increasing attention in the last decade. Seen as one whole complex and grey system, the causal relationship between the social development and the air pollution in Beijing has been quantitatively analyzed in this paper. By using the grey relational model, the aim of this study is to explore how the socio-economic and human activities affect on the air pollution in the city of Beijing, China. Four air pollutants, as the particulate matter with size 2.5 micrometers or less (PM
Distal turbidite fan/lobe succession of the Late Oligocene Zuberec Fm. – architecture and hierarchy (Central Western Carpathians, Orava–Podhale basin)
Authors: Starek Dušan , Fuksi Tomáš 
Published: August 2017

AbstractA part of the Upper Oligocene sand-rich turbidite systems of the Central Carpathian Basin is represented by the Zuberec Formation. Sand/mud-mixed deposits of this formation are well exposed in the northern part of the basin, allowing us to interpret the turbidite succession as terminal lobe deposits of a submarine fan. This interpretation is based on the discrimination of three facies associations that are comparable to different components of distributive lobe deposits in deep-water fan systems. They correspond to the lobe off-axis, lobe fringe and lobe distal fringe depositional subenvironments, respectively. The inferences about the depositional paleoenvironment based on sedimentological observations are verified by statistical analyses. The bed-thickness frequency distributions and vertical organization of the facies associations show cyclic trends at different hierarchical levels that enable us to reconstruct architectural elements of a turbidite fan. First, small-scale trends correspond with shift in the lobe element centroid between successive elements. Differences in the distribution and frequency of sandstone bed thicknesses as well as differences in the shape of bed-thickness frequency distributions between individual facies associations reflect a gradual fining and thinning in a down-dip direction. Second, meso-scale trends are identified within lobes and they generally correspond to the significant periodicity identified by the time series analysis of the bed thicknesses. The meso-scale trends demonstrate shifts in the position of the lobe centroid within the lobe system. Both types of trends have a character of a compensational stacking pattern and could be linked to autogenic processes. Third, a largescale trend documented by generally thickening-upward stacking pattern of beds, accompanied by a general increase of the sandstones/mudstones ratio and by a gradual change of percentage of individual facies, could be comparable to lobe-system scale. This trend probably indicates a gradual basinward progradation of lobe system controlled by allogenic processes related to tectonic activity of sources and sea-level fluctuations.
Mechanical behavior of walnut (Juglans regia L.) and cherry (Prunus avium L.) wood in tension and compression in all anatomical directions. Revisiting the tensile/compressive stiffness ratios of wood
Authors: Bachtiar Erik V. , Rüggeberg Markus , Niemz Peter 
Published: August 2017

Abstract
The mechanical properties of walnut (Juglans regia L.) and cherry (Prunus avium L.) woods, as frequent raw materials in cultural heritage objects, have been investigated as a function of the anatomical directions and the moisture content (MC). The strength data are decreasing with increasing MC, whereas the tensile strength in the longitudinal direction is higher by factors of 1.5–2 compared to the compression strength. Moreover, the inequality of tensile and compressive stiffness is discussed, which is a matter of debate since a long time. This so-called bimodular behavior is difficult to describe in a generalized mode due to the high data variability if tension and compression properties are analyzed on different samples. If tensile and compressive stiffness tests are performed on the same samples of walnut and cherry wood, the ratio between these properties is significantly higher than 1.
Significance of diarylheptanoids for chemotaxonomical distinguishing between Alnus glutinosa and Alnus incana
Authors: Vidaković Vera , Novaković Miroslav , Popović Zorica , Janković Milan , Matić Rada , Tešević Vele , Bojović Srdjan 
Published: August 2017

Abstract
Diarylheptanoids are a group of secondary metabolites widely distributed in the Betulaceae family and characteristic for Alnus species. In this study, the chemotaxonomic power of diarylheptanoids, such as hirsutanonol-5-O-β-d-glucopyranoside, rubranoside A, oregonin, platyphylloside, alnuside A and hirsutanonol, has been investigated in combination with principal component analysis (PCA) for differentiation of Alnus species. Concentrations of six diarylheptanoids in the bark extracts of two natural populations of Alnus glutinosa (black alder) and Alnus incana (gray alder) were determined by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). PCA clearly shows the separation of three groups. Populations I (A. glutinosa) and II (A. incana) both consisted of individuals of the corresponding species. Four individuals from both sampled populations formed a separate group (population III), which possibly represents a hybrid group. Accordingly, diarylheptanoids may serve in combination with PCA as chemotaxonomic markers at the species level, which may also reveal hybrid species.
Rapid automatized processing of nouns and verbs in typical
children
Authors: Biddappa Priya M. , Seth Divya , Manjula R. 
Published: August 2017

Abstract
The utility of Rapid Automatized Naming (RAN) as a clinical tool to
predict later reading abilities was addressed by researchers as early as the
1970s. Over the years, several variants of the task came into existence such
as inclusion of a variety of stimuli, varying picture size, etc. but very
few have addressed the response modality. The study aimed to compare rapid
processing skills in typical children in verbal and non-verbal modalities
using picture arrays of nouns and verbs. Twenty typically developing
children in the age range of 5–7 years participated in the study. Picture
arrays of five common nouns and verbs each served as the stimuli. The task
comprised picture naming and picture pointing. The results revealed that
nouns were processed faster than verbs in both verbal and non-verbal
modalities. It was also found that there was no difference in the processing
of nouns between the two modalities unlike verbs. Overall, the results point
to the potential use of a non-verbal task to assess the rapid processing
skills in children with limited verbal abilities.
Foreign Direct Investment and Growth Symbiosis: A Semiparametric System of Simultaneous Equations Analysis
Authors: McCloud Nadine , Delgado Michael S. , Kumbhakar Subal C. 
Published: August 2017

AbstractWe characterize the types of interactions between foreign direct investment (FDI) and economic growth, and analyze the effect of institutional quality on such interactions. To do this analysis, we develop a class of instrument-based semiparametric system of simultaneous equations estimators for panel data and prove that our estimators are consistent and asymptotically normal. Our new methodological tool suggests that across developed and developing economies, causal, heterogeneous symbiosis and commensalism are the most dominant types of interactions between FDI and economic growth. Higher institutional quality facilitates, impedes or has no effect on the interactions between FDI and economic growth.