bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical Characterization and Evaluation of Anti-oxidant Activity of <i>Ipomoea obscura</i> (L.)
Authors: Agase Durgesh , Saini K. S. , Markam M. S. , Kale A. S. , Kothe T. S. , Ukey S. , Khan S. , Turkar S. 
Published: September 2024

Background: Dietary botanicals, including food additives, fruits, and vegetables, have been used for centuries as natural health remedies, but scientific evidence on their preventive properties remains limited. These dietary plants are a significant source of many natural antioxidants. Natural herbal medicines have no side effects on human health so these herbal medicines can be a safe alternative to harmful allopathic medicines. Aim: In this study, we evaluated the antioxidant potential of Ipomoea obscura leaf extract and profiled the bioactive compounds of the leaf extract. Methods: UV-visible spectroscopy, DPPH analysis, and LC-MS analysis. Results: UV-visible analysis of water, ethanol, and methanol extracts of I. obscura showed maximum absorption at 310.0 nm, 413 nm, and 337 nm. Results of DPPH analysis showed that the aqueous extract (53.80 ± 1.45, R2 = 0.92) has the maximum antioxidant potential compared to the ethanol and methanol extracts. Phytochemical analysis of the aqueous extract of I. obscura revealed several phytochemicals including alkaloids, carbohydrates, phenols, proteins, and saponins. LC-MS data confirmed the presence of 12 bioactive compounds in the aqueous extract of I. obscura leaves. Conclusion: The study reveals that the aqueous extract of I. obscura exhibits high antioxidant potential compared to ethanolic and methanolic extracts and has active secondary metabolites.
Impact of <i>Ayurveda</i> Pre-monsoon Prophylaxis on Episodes and Severity of Fever, Cough and Cold in North Karnataka - A Cross-sectional Survey Study
Authors: Chandran Amal S. , Prasad B. S. , Kaimal V. Sreeja , Khare Divya 
Published: September 2024

Background: Though monsoons are a real gift of nature, it is a meteorological phenomenon which brings in lots of losses in terms of money and life through the upsurge of various infectious diseases in India. According to Ayurveda, immunity is comparatively lower during the monsoon season. So, it is in practice in our institute to provide pre-monsoon prophylaxis to all interested staff and students to boost immunity. Objective: The present retrospective cross-sectional study was planned to assess the impact of Ayurveda Pre-monsoon Prophylaxis on the severity and frequency of episodes of fever, cough and cold in healthy volunteers. Methods: After obtaining ethical clearance for the cross-sectional study, a survey using Google Forms was conducted. A Google form was created to assess the health condition as well as the frequency and severity of cough, cold and fever in the study subjects before and after prophylaxis. Detailed scrutiny of the respondents was carried out by the investigators. The Google forms of people who participated in the prophylaxis and visited for follow-up six months after receiving monsoon prophylaxis were included in the analysis. The data was analyzed using paired t-test. Results: A total of 591 participants out of 806 met the inclusion criteria and participated in the study. A highly significant (p<0.001) reduction in the frequency of episodes and severity of fever, cold, and cough was found in the study subjects after prophylaxis. Conclusion: So, it may be inferred that Ayurveda Pre-monsoon prophylaxis is an effective practice to enhance overall health and thereby boost the immunity of individuals.
UNVEILING THE MYSTERY OF MAN’S ORIGIN AND CREATION: A COMPARATIVE STUDY OF QURAN AND SCIENCE
Authors: Zaheer Nosheen , Shaheen Farzana , Naheed Kishwar , Rukhsana Rukhsana 
Published: September 2024

Purpose of the study: To explore the creation of the first human, Adam (A.S.), and his progeny through religious (Quranic) and scientific (biochemical and embryological) perspectives.
Methodology: The methodology involves analyzing the origin of the first human, Adam (A.S.), and his progeny by comparing Quranic verses with scientific evidence from biochemical evolution and embryological research.
Main Findings: The findings reveal a strong parallel between the Quranic description of Adam’s (A.S.) creation and the scientific theory of chemical evolution, as well as a precise alignment between Quranic accounts of human development and the stages of embryology, providing insight into the harmony between religion and science on the origin of humanity.
Applications of the study: This research can be applied to foster a deeper understanding and dialogue between religious and scientific communities by demonstrating how Quranic teachings on creation align with modern scientific theories, thereby promoting an integrated approach to studying human origins that bridges faith and reason.
Novelty/Originality of the study: This study's originality lies in integrating religious and scientific perspectives on human creation by comparing the Quranic account of Adam (A.S.) with biochemical evolution and embryology, offering new insights into their convergence.
CAMINHOS DAS ÁGUAS E MODO DE VIDA QUILOMBOLA AMAZÔNICO
Authors: Silva Brenda Caroline Martins da , Castro Nádile Juliane Costa de 
Published: September 2024

Para compreensão de comportamentos singulares de populações a partir do campo da saúde coletiva é necessário identificar elementos que compõe cenários. Assim como em outras comunidades quilombolas, Ipanema de Abaetetuba, Pará, Brasil, tem seu modos de vida, muito bem conectado com os caminhos da águas, recurso importante entre esse grupo e que permeia seu ir e vir. Apresenta-se, portanto registros para iniciar uma discussão sobre determinantes de saúde e demandas em saúde a partir das singularidades locais que envolvem a vida local, realizado por meio de uma pesquisa da área de saúde coletiva, em que teve como um dos objetivos os registros do modo de vida.
Dissensus sur le renouvellement du glyphosate
Authors: Agathe Chirossel 
Published: September 2024

©Pixabay
L’autorisation du glyphosate par la Commission européenne pour une durée de dix années le 28 novembre 2023 intervient à l’issue d’un processus complexe de négociations. La Commission a dû dépasser l’abstention de sept États membres, qui n’a pas permis d’obtenir la double majorité. Faisant peser la responsabilité d’un tel renouvellement sur la seule Commission, l’affaire du glyphosate souligne les difficultés institutionnelles que peut connaître le processus décisionnel de l’Union européenne. Plus spécifiquement, la décision de renouvellement illustre une absence de choix politique de la part des États membres. Émerge alors un paradoxe de plus en plus profond entre solutions jurisprudentielles et renouvellement législatif national restreignant l’utilisation du glyphosate, et absence de positionnement lors du processus législatif européen induisant in fine une solution favorable à la commercialisation de ce produit.
The European Commission's authorisation of glyphosate for ten years on 28 November 2023 follows a complex process of negotiations. The Commission had to overcome the abstention of seven Member States, which prevented it from obtaining a double majority. By placing the responsibility for such a renewal solely on the Commission, the glyphosate affair highlights the institutional difficulties that can arise in the European Union's decision-making process. More specifically, the renewal decision illustrates a lack of political choice on the part of the Member States. An increasingly profound paradox is emerging, between the solutions provided by case law and the renewal of national legislation restricting the use of glyphosate, and the absence of a position during the European legislative process that would ultimately lead to a solution favourable to the marketing of this product.
KARAKTERISTIK AKUIFER AIRTANAH DANGKAL DI ENDAPAN MUDA MERAPI YOGYAKARTA
Authors: Febriarta Erik , Larasati Ajeng , Larasati Ajeng 
Published: September 2024

Peran air tanah semakin lama semakin penting dan strategis karena menyangkut kebutuhan dasar hajat hidup orang banyak dalam berbagai aktivitas masyarakat. Pemanfaatan air tanah dalam suatu cekungan air tanah perlu mempetimbangkan potensi yang terkandung dalam suatu cekungan tersebut, agar pemanfaatannya dapat dilakukan secara optimal dan berkelanjutan. Penelitian ini bertujuan untuk mengetahui 1) laju pergerakan tanah atau keterusan air tanah, 2) nilai kemampuan batuan meluuskan air di dalam rongga batuan, dan 3) pengaruh jari-jari pemompaan. Nilai uji pompa (pumping test) merupakan salah satu teknik yang dilakukan untuk mengetahui karakteristik akuifer. Lokasi uji pompa (pumping test) berada di Kecamatan Sewon Kabupaten Bantul, secara litologi adalah material lepas berupa pasiran hasil pengendapan aktivitas Gunungapi Merapi, yang secara morfologi berada di kaki Gunungapi Merapi, yang secara hidrogeologi termasuk pada zona lepasan air tanah atau daerah discharge. Metode yang digunakan untuk mengatahui parameter akuifer adalah pemompaan periode pendek dengan pendekatan perhitungan Theis dan Cooper-Jacob. Hasil pemompaan menunjukan karakteritik hasil transmivitas (T) rata-rata adalah 1048,6 m2/hari dan nilai rata-rata konduktivitas hidrolik (K) adalah 679,8 m/hari. Berdasarkan karakteristik tersebut, potensi jari-jari pengaruh pemompaan sebesar 17,67 m.
Trends in Nonfatal Overdose Rates Due to Alcohol and Prescription and Illegal Substances in Colombia, 2010‒2021
Authors: Santaella-Tenorio Julian , Zapata-López Jhoan S. , Fidalgo Thiago M. , Tardelli Vítor S. , Segura Luis E. , Cerda Magdalena , Martins Silvia S. 
Published: September 2024

Objectives. To examine drug overdoses in Colombia by type of substance, sex, age, and intent using data from a health surveillance system from 2010 to 2021. Methods. We characterized data by year, type of substance, and sociodemographic variables. We calculated age-adjusted overdose rates by substance type, sex, age groups, and intent. We used Poisson regression models to examine trend differences across sex and age groups. Results. Age-adjusted rates of drug overdoses increased from 8.51 to 40.52 per 100 000 during 2010 to 2021. Men, compared with women, had higher overdose rates for every substance, except for opioids and psychotropics. Drug overdose rates involving cannabis and stimulants increased steadily until 2017 but decreased afterward. Overdose rates involving psychotropic medication increased greatly during 2018 to 2021, mainly because of intentional overdoses in young women. Conclusions. Overdoses involving illegal drugs decreased in recent years in Colombia; however, the continuous increase in intentional psychotropic overdose rates highlights the need for prevention efforts to curb this trend. Health surveillance systems are an important tool that can guide overdose prevention efforts in countries with limited data resources. ( Am J Public Health. 2024;114(11):1252–1260. https://doi.org/10.2105/AJPH.2024.307786 )
Stochastic Modeling of Two-Phase Transport in Fractured Porous Media Under Geological Uncertainty Using an Improved Probabilistic Collocation Method
Authors: Sharafi Mohammad Sadegh , Ahmadi Mohammad , Kazemi Alireza 
Published: September 2024

Summary
Simulation of multiphase transport through fractured porous media is highly affected by the uncertainty in fracture distribution and matrix block size that arises from inherent heterogeneity. To quantify the effect of such uncertainties on displacement performance in porous media, the probabilistic collocation method (PCM) has been applied as a feasible and accurate approach. However, propagation of uncertainty during the simulation of unsteady-state transport through porous media could not be computed by this method or even by the direct-sampling Monte Carlo (MC) approach. Therefore, with this research, we implement a novel numerical modeling workflow that improves PCM on sparse grids and combines it with the Smolyak algorithm for selection of collocation points sets, Karhunen-Loeve (KL) decomposition, and polynomial chaos expansion (PCE) to compute the uncertainty propagation in oil-gas flow through fractured porous media in which gravity drainage force is enabled. The effect of uncertainty in the vertical dimension of matrix blocks, which are frequently an uncertain and history-matching parameter, on simulation results of randomly synthetic 3D fractured media is explored. The developed numerical model is innovatively coupled with solving governing deterministic partial differential equations (PDEs) to compute uncertainty propagation from the first timestep to the last timestep of the simulation. The uncertainty interval and aggregation of uncertainty in ultimate recovery are quantified, and statistical moments for simulation outputs are presented at each timestep. The results reveal that the model properly quantifies uncertainty and extremely reduces central processing unit (or CPU) time in comparison with MC simulation.
Efficacy of Virtual Reality in Managing Pain for Palliative Patients: A Systematic Review and Meta-Analysis Protocol
Authors: Salim Nezar N/A , Taylor Janiece 
Published: September 2024

Abstract

Background: Virtual Reality (VR) has demonstrated effectiveness as an intervention for pain management. With technological advances and increased affordability, VR offers promising tools for managing pain among palliative patients. The primary aim of this systematic review and metaanalysis is to synthesize evidence from published Randomized Clinical Trials (RCTs) on the use of VR for pain management among palliative patients.
Objectives: To evaluate the efficacy of VR interventions in reducing pain among palliative care patients and to assess the methodological quality of the included studies.
Data Sources: Literature searches were conducted in databases including PubMed, Embase, CINAHL, and the Cochrane Database of Systematic Reviews, utilizing medical subject headings (MeSH) and keywords such as "Palliative Patients," "Hospice Patients," "End of Life Cancer Patients," "Pain Management," "Virtual Reality," and "Randomized Clinical Trials." Study Eligibility Criteria: Studies included were RCTs focusing on VR interventions for pain management in palliative care settings.
Participants/Interventions: Palliative care patients receiving VR interventions for pain management.
Study Appraisal and Synthesis Methods: The Joanna Briggs Institute’s “Revised Critical Appraisal Checklist for Randomized Controlled Trials” was used to appraise the methodological quality. Two independent reviewers conducted study selection, data extraction, and quality assessment, with discrepancies resolved through consultation with a third reviewer. Quantitative analyses were performed using SPSS, calculating standardized mean differences and odds ratios, and assessing heterogeneity with the I2 statistic.
Results: The review will summarize the effect sizes and confidence intervals of VR interventions on pain management in palliative care, with an evaluation of the consistency of the results across studies.
Limitations: Limitations of the study will include potential publication bias and the inherent methodological limitations in the included studies.
Conclusions and Implications of Key Findings: Findings are expected to provide robust evidence on the efficacy of VR for pain management in palliative care and highlight areas for future research.
Systematic Review Registration Number: PROSPERO [CRD42024512961].
Ethics and Dissemination: No ethical approval is required for this review. Results will be disseminated through conference presentations and publication in a peer-reviewed journal.
Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators
Authors: ling yating , Hayat Muhammad Abid , Lv Xiaorui , Niu Dongdong , Zeng Yu , Qiu Yun , Chen Bo , Hu Jiabo 
Published: September 2024

Abstract

Unfolded protein response (UPR) signaling in cells stimulates UPR signaling in adjacent cells, facilitating disease progression by upregulating UPR target genes. However, whether this dissemination occurs between nerve cells and its molecular basis remains unclear. The supernatant of endoplasmic reticulum (ER) stress in rat astrocytes was prepared and treated with rat adrenal medulla pheochromocytoma cells to simulate the propagation of ER stress between nerve cells. The results showed that ER stress may propagate between rat nerve cells, ultimately leading to cell death. It was also found that the mediators mediating ER stress transmission have non-vesicular, oxidative-linked molecules with molecular weights > 100 kD. In conclusion, ER stress propagation might play a significant role in neuronal death following ER stress in central nervous system (CNS) diseases, suggesting novel therapeutic targets for these conditions.
Mortality Predictors of Patients Receiving Care in a Geriatric Home Care Unit, During a Six Months Follow-up After the Intervention
Authors: Prieto Blanca Garmendia , Usaola Francisco Sánchez del Corral , Cortés Juan José Baztán , Pavón Francisco Javier Gómez 
Published: September 2024

Abstract

Purpose: To describe the characteristics of patients attended by a Home Geriatric Care Unit (HGCU) and the predictors of mortality during the intervention and after 6 months of follow-up.
Methods: This prospective observational study included patients attended by the HGCU of the Hospital Universitario Central de la Cruz Roja (from June 1 to December 31, 2021) with a 6-month follow-up. Sociodemographic, clinical, functional, and cognitive variables were recorded, together with the waiting times until the first visit, length of stay, number of new diagnoses, additional tests, origin, and the number of medical and nursing visits. Mortality and its predictors were assessed. Descriptive and multivariate analyses were performed, along with Kaplan-Meier curves (95%CI; p<0.05).
Results: 241 patients were included (89.4±6.1 years; 72.6% women). There was high co-morbidity (38.9% Charlson Index≥3), frailty (Clinical Frailty Scale-CFS≥5: 97.9%), polypharmacy (average number of medications was 12.1±4.6), Barthel Index (BI) mean 39.9±27.3, with 60.1% having dementia and 70.1% Nutritional risk (CONtrolling NUTritional Status-CONUT>1). Anemia was found in 43% and renal function impairment (glomerular filtration rate <60 ml/min/m2) in 90.4%. The average length of participation in the program was 17.4±17.9 days, with 2.9±2.7 medical visits and 2.7±2.7 nursing visits. New diagnoses were established in 83.8% of patients. Mortality was 5.4% (13 patients) during the intervention and 22.8% at 6 month. Predictive variables of mortality in multivariate analysis included worse functional and cognitive status at discharge, poorer nutritional status and renal function, higher number of medical and nursing visits, and new diagnoses establishment.
Conclusion: The HGCU program cares for older patients with high co-morbidity and care needs, complementing the role of Primary Care. Factors such as functional, cognitive and nutritional status, renal function, and the number of medical and nursing visits are predictors of mortality at 6 months.
Combined Effects and Timing of Robotic Training and Botulinum Toxin on Upper Limb Spasticity and Motor Function among individuals with post-stroke upper limb spasticity
Authors: Shin Joon-Ho , Park Gyulee , Kim Hayeon , Cho Duk Youn , Kwon Suncheol 
Published: September 2024

Abstract

Objective:This study aimed to evaluate the combined effects of robotic training (RT) and botulinum toxin (BTX) injections on motor function and spasticity in individuals with post-stroke upper limb spasticity (ULS). We also investigated the optimal timing of RT and BTX administration.
Methods:Forty-two participants with chronic stroke-induced ULS were initially enrolled and randomized into four groups: Group A (RT+BTX at 4 weeks [W4]), Group B (RT+BTX at baseline [W0]), Group C (BTX at W0, RT at W4), and Group D (RT at W0, BTX at W4). Clinical assessments and robotic kinematic evaluations were conducted at W0, W4, and 8 weeks (W8). The primary outcome was the Fugl-Meyer Assessment (FMA) scores, and secondary outcomes included the modified Ashworth scale (MAS) of elbow and kinematic parameters such as spectral arc length mean speed, hand path ratio, and movement deviation in various movements.
Results:Of the 42 participants, 40 completed the study. From W0 to W4, Group B showed the best results in terms of spasticity (MAS-elbow flexor and extensor) and kinematic variables, indicating that the combined use of BTX and RT is superior to sole interventions regarding motor function and spasticity. From W0 to W8, Group C demonstrated the most significant improvements in FMA scores and kinematic variables, indicating that the combined use of BTX and RT, especially when RT was initiated one month after BTX injection, resulted in superior functional outcomes compared to other timings of interventions.
Conclusions: The combination of RT and BTX is more effective in enhancing motor function and reducing spasticity in individuals with ULS than either intervention alone or no intervention. Moreover, the timing of RT relative to BTX injection plays a crucial role in maximizing therapeutic benefits in stroke patients with ULS, considering the mode of action of each intervention.
Trial registration: clinicaltrials.gov NCT02228863. Registered 23 Auguste 2014; retrospectively registered.
Identifying Diagnostic Biomarkers for Glaucoma Based on Transcriptome Combined with Mendelian Randomization
Authors: Lin Xiuli , Ma Chuanyong , Zhang Xiaoxue , Qiu Yuzhe , Xu Nuo 
Published: September 2024

Abstract

Glaucoma poses a major health challenge, yet reliable biomarkers for diagnosis and treatment are scarce. This study employed Mendelian randomization and bioinformatics to uncover potential biomarkers. The GSE9944 dataset was used for training and validation in glaucoma research. Differentially expressed genes (DEGs) were identified through differential expression analysis. The protein-protein interaction network (PPI) and functional enrichment were conducted. MR analysis selected DEGs for support vector machine-recursive feature elimination (SVM-RFE), and genes with high differential expression and an area under the curve (AUC) > 0.7 were deemed biomarkers. Biomarker-based analysis, network design, and drug prediction followe. Using 836 DEGs, the PPI network showed diverse interactions, including ATG14-UVRAG. DEGs were enriched in PI3K-Akt and MAPK pathways. MR analysis linked 113 DEGs to glaucoma, with 57 genes matching expression trends. SVM-RFE identified six signature genes, with ATP6V0D1 and FAM89B as biomarkers (AUC > 0.7). Finally, the molecular regulatory networks revealed that biomarkers might involve several regulatory pathways, including ATP6V0D1-hsa-let-7b-5p-HCG18 and ATP6V0D1 or FAM89B-CREB1. The ATP6V0D1 and FAM89B recognized as glaucoma biomarkers, aiding diagnosis, treatment and deepening glaucoma mechanisms understanding