bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Cretaceous and Early Paleogene Fluid Circulation and Microbial Activity in Deep Fracture Networks of the Precambrian Basement of Western Greenland
Authors: Drake H. , Makahnouk W. R. M. , Roberts N. M. W. , Reinhardt M. , Henkemans E. , Frape S. K. , Tullborg E.‐L. , Broman C. , Whitehouse M. J. , Kooijman E. 
Published: September 2024

AbstractDeep fracture‐hosted fluids of Precambrian bedrock cratons are relatively stagnant over long time spans compared to near‐surface systems. However, episodic events, such as fracture reactivations, transgressions, and deglaciations, may introduce dilute water, replacing, and mixing with the deep continental brines, thereby sparking microbial activity. Secondary minerals that line bedrock fractures serve as important geochemical archives for such episodic events. Here we explore the fracture mineral record of Archean rocks of Western Greenland by analyzing samples from deep boreholes with the aim to trace and characterize episodic paleofluid flow and paleomicrobial activity. A sequence of hydrothermal to low temperature fluid flow events is demonstrated. For the youngest generation, microscale S‐isotope analysis of pyrite reveals substantial 34S‐depletion (minimum δ34S:−58‰V‐CDT) compared to fracture‐hosted barite (δ34S:13‰ ± 2‰) and gypsum (δ34S:2.6‰–10.6‰). This suggests the formation of pyrite following S isotope fractionation during microbial sulfate reduction. This metabolism is further indicated by several methyl‐branched fatty acids preserved in calcite. A general discrepancy between calcite and groundwater δ18O‐values suggests that calcite formed from water different from the presently residing glacial meltwater‐influenced groundwater mix. High spatial resolution U‐Pb carbonate geochronology of the youngest generation of calcite yielded ages for two samples: 64 ± 3, 75 ± 7 Ma (2σ). These ages overlap with tectonic events related to early stages, or prestages, of the opening of the Atlantic and Labrador Seas. This suggests that deep fracture networks in Western Greenland were colonized by microorganisms, such as sulfate reducers, in the course of this extensional event.
A low-voltage-driven MEMS ultrasonic phased-array transducer for fast 3D volumetric imaging
Authors: Zhang Yun , Jin Tong , Deng Yining , Zhao Zijie , Wang Rui , He Qiong , Luo Jianwen , Li Jiawei , Du Kang , Wu Tao , Yan Chenfang , Zhang Hao , Lu Xinchao , Huang Chengjun , Gao Hang 
Published: September 2024

AbstractWearable ultrasound imaging technology has become an emerging modality for the continuous monitoring of deep-tissue physiology, providing crucial health and disease information. Fast volumetric imaging that can provide a full spatiotemporal view of intrinsic 3D targets is desirable for interpreting internal organ dynamics. However, existing 1D ultrasound transducer arrays provide 2D images, making it challenging to overcome the trade-off between the temporal resolution and volumetric coverage. In addition, the high driving voltage limits their implementation in wearable settings. With the use of microelectromechanical system (MEMS) technology, we report an ultrasonic phased-array transducer, i.e., a 2D piezoelectric micromachined ultrasound transducer (pMUT) array, which is driven by a low voltage and is chip-compatible for fast 3D volumetric imaging. By grouping multiple pMUT cells into one single drive channel/element, we propose an innovative cell–element–array design and operation of a pMUT array that can be used to quantitatively characterize the key coupling effects between each pMUT cell, allowing 3D imaging with 5-V actuation. The pMUT array demonstrates fast volumetric imaging covering a range of 40 mm × 40 mm × 70 mm in wire phantom and vascular phantom experiments, achieving a high temporal frame rate of 11 kHz. The proposed solution offers a full volumetric view of deep-tissue disorders in a fast manner, paving the way for long-term wearable imaging technology for various organs in deep tissues.
The NRF2-CARM1 axis links glucose sensing to transcriptional and epigenetic regulation of the pentose phosphate pathway in gastric cancer
Authors: Ping Miaomiao , Li Guangyao , Li Qijiao , Fang Yang , Fan Taotao , Wu Jing , Zhang Ruiyi , Zhang Lesha , Shen Bing , Guo Jizheng 
Published: September 2024

AbstractCancer cells autonomously alter metabolic pathways in response to dynamic nutrient conditions in the microenvironment to maintain cell survival and proliferation. A better understanding of these adaptive alterations may reveal the vulnerabilities of cancer cells. Here, we demonstrate that coactivator-associated arginine methyltransferase 1 (CARM1) is frequently overexpressed in gastric cancer and predicts poor prognosis of patients with this cancer. Gastric cancer cells sense a reduced extracellular glucose content, leading to activation of nuclear factor erythroid 2-related factor 2 (NRF2). Subsequently, NRF2 mediates the classic antioxidant pathway to eliminate the accumulation of reactive oxygen species induced by low glucose. We found that NRF2 binds to the CARM1 promoter, upregulating its expression and triggering CARM1-mediated hypermethylation of histone H3 methylated at R arginine 17 (H3R17me2) in the glucose-6-phosphate dehydrogenase gene body. The upregulation of this dehydrogenase, driven by the H3R17me2 modification, redirects glucose carbon flux toward the pentose phosphate pathway. This redirection contributes to nucleotide synthesis (yielding nucleotide precursors, such as ribose-5-phosphate) and redox homeostasis and ultimately facilitates cancer cell survival and growth. NRF2 or CARM1 knockdown results in decreased H3R17me2a accompanied by the reduction of glucose-6-phosphate dehydrogenase under low glucose conditions. Collectively, this study reveals a significant role of CARM1 in regulating the tumor metabolic switch and identifies CARM1 as a potential therapeutic target for gastric cancer treatment.
Influence of geographic isolation and the environment on gene flow among phenotypically diverse lizards
Authors: McGreevy Thomas J. , Crawford Nicholas G. , Legreneur Pierre , Schneider Christopher J. 
Published: September 2024

AbstractLizards in the genus Anolis comprise hundreds of species that display a wide range of phenotypic variation closely related to their environment. One example is the Guadeloupean anole (Anolis marmoratus ssp.) that display extreme phenotypic variation, primarily in adult male color and pattern, with twelve described subspecies on the archipelago. Here we examine the relationship between phenotypic and genetic divergence among five subspecies on the two main islands and test the role of geographic isolation and the environment in reducing gene flow. We also examined two offshore island populations to assess the impact of complete geographic isolation on gene flow. We analyzed color phenotypes by measuring spectral reflectance and genomic diversity using SNPs. Genetic divergence was correlated with dorsolateral head and body color phenotypes, and slope and geographic distance were nearly equivalent at explaining this divergence. There was minimal genome-wide divergence at neutral loci among phenotypically disparate subspecies on the two main islands and their differentiation is consistent with a model of divergence with gene flow. Our spatial visualization of gene flow showed an impact of environmental features consistent with a hypothesis of ecologically driven divergence. Nonetheless, subspecies on the two main islands remain interconnected by substantial gene flow and their phenotypic variation is likely maintained at selection-gene flow equilibrium by divergent selection at loci associated with their color phenotypes. Greater isolation, such as inhabiting a remote island, may be required for reducing gene flow. Our findings highlight the role of the environment, adaptation, and geographic isolation on gene flow.
Similarity and economy of scale in urban transportation networks and optimal transport-based infrastructures
Authors: Leite Daniela , De Bacco Caterina 
Published: September 2024

AbstractDesigning and optimizing the structure of urban transportation networks is a challenging task. In this study, we propose a method inspired by optimal transport theory and the principle of economy of scale that uses little information in input to generate structures that are similar to those of public transportation networks. Contrarily to standard approaches, it does not assume any initial backbone network infrastructure but rather extracts this directly from a continuous space using only a few origin and destination points, generating networks from scratch. Analyzing a set of urban train, tram and subway networks, we find a noteworthy degree of similarity in several of the studied cases between simulated and real infrastructures. By tuning one parameter, our method can simulate a range of different subway, tram and train networks that can be further used to suggest possible improvements in terms of relevant transportation properties. Outputs of our algorithm provide naturally a principled quantitative measure of similarity between two networks that can be used to automatize the selection of similar simulated networks.
Interplay between disorder and electronic correlations in compositionally complex alloys
Authors: Redka David , Khan Saleem Ayaz , Martino Edoardo , Mettan Xavier , Ciric Luka , Tolj Davor , Ivšić Trpimir , Held Andreas , Caputo Marco , Guedes Eduardo Bonini , Strocov Vladimir N. , Di Marco Igor , Ebert Hubert , Huber Heinz P. , Dil J. Hugo , Forró László , Minár Ján 
Published: September 2024

AbstractOwing to their exceptional mechanical, electronic, and phononic transport properties, compositionally complex alloys, including high-entropy alloys, represent an important class of materials. However, the interplay between chemical disorder and electronic correlations, and its influence on electronic structure-derived properties, remains largely unexplored. This is addressed for the archetypal CrMnFeCoNi alloy using resonant and valence band photoemission spectroscopy, electrical resistivity, and optical conductivity measurements, complemented by linear response calculations based on density functional theory. Utilizing dynamical mean-field theory, correlation signatures and damping in the spectra are identified, highlighting the significance of many-body effects, particularly in states distant from the Fermi edge. Electronic transport remains dominated by disorder and potentially short-range order, especially at low temperatures, while visible-spectrum optical conductivity and high-temperature transport are influenced by short quasiparticle lifetimes. These findings improve our understanding of element-specific electronic correlations in compositionally complex alloys and facilitate the development of advanced materials with tailored electronic properties.
Super-resolution techniques to simulate electronic spectra of large molecular systems
Authors: Kick Matthias , Alexander Ezra , Beiersdorfer Anton , Van Voorhis Troy 
Published: September 2024

AbstractAn accurate treatment of electronic spectra in large systems with a technique such as time-dependent density functional theory is computationally challenging. Due to the Nyquist sampling theorem, direct real-time simulations must be prohibitively long to achieve suitably sharp resolution in frequency space. Super-resolution techniques such as compressed sensing and MUSIC assume only a small number of excitations contribute to the spectrum, which fails in large molecular systems where the number of excitations is typically very large. We present an approach that combines exact short-time dynamics with approximate frequency space methods to capture large narrow features embedded in a dense manifold of smaller nearby peaks. We show that our approach can accurately capture narrow features and a broad quasi-continuum of states simultaneously, even when the features overlap in frequency. Our approach is able to reduce the required simulation time to achieve reasonable accuracy by a factor of 20-40 with respect to standard Fourier analysis and shows promise for accurately predicting the whole spectrum of large molecules and materials.
Enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones enabled by asymmetric Lewis acid catalysis
Authors: Wu Wen-Biao , Xu Bing , Yang Xue-Chun , Wu Feng , He Heng-Xian , Zhang Xu , Feng Jian-Jun 
Published: September 2024

AbstractThe absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery. Here we demonstrate the achievability of an asymmetric polar cycloaddition of bicyclo[1.1.0]butane using a chiral Lewis acid catalyst and a bidentate chelating bicyclo[1.1.0]butane substrate, as exemplified by the current enantioselective formal (3 + 3) cycloaddition of bicyclo[1.1.0]butanes with nitrones. In addition to the diverse bicyclo[1.1.0]butanes incorporating an acyl imidazole group or an acyl pyrazole moiety, a wide array of nitrones are compatible with this Lewis acid catalysis, successfully assembling two congested quaternary carbon centers and a chiral aza-trisubstituted carbon center in the pharmaceutically important hetero-bicyclo[3.1.1]heptane product with up to 99% yield and >99% ee.
Open-label placebos reduce weight in obesity: a randomized controlled trial
Authors: Schaefer Michael , Kühnel Anja , Enge Sören 
Published: September 2024

AbstractObesity is a major public health problem worldwide. Different approaches are known to face this problem, for example, dieting, surgery, or drug interventions. It has also been shown that placebos may help to reduce weight and hunger feelings, but the use of placebos is linked to problems with respect to the patient-healthcare-provider relationship. However, recent studies demonstrated that even placebos without deception (open-label placebos) affect symptoms such as pain, anxiety, or emotional distress. Here we aimed to examine whether an open-label placebo may help to lose weight in obesity. Our study included fifty-seven overweight and obese patients who aimed to lose weight using a combination of diet and sports. Patients were randomly divided into two groups. Participants in the open-label placebo group received two placebos each day. A treatment-as-usual group received no pills. Primary outcome included changes of body weight. Secondary outcomes were change of eating behavior and self-management abilities. After 4 weeks we found that participants in the open-label placebo condition lost more weight than the treatment-as-usual group. Furthermore, OLP treatment affected eating behavior. No effects for self-management abilities were found. Although further research is necessary, open-label placebos might help individuals to lose weight.
Epigenetic silencing of ZIC4 unveils a potential tumor suppressor role in pediatric choroid plexus carcinoma
Authors: Hesham Dina , Mosaab Amal , Amer Nada , Al-Shehaby Nouran , Magdeldin Sameh , Hassan Ahmed , Georgiev Hristo , Elshoky Hisham , Rady Mona , Aisha Khaled Abou , Sabet Ola , El-Naggar Shahenda 
Published: September 2024

AbstractZic family member ZIC4 is a transcription factor that has been shown to be silenced in several cancers. However, understanding the regulation and function of ZIC4 in pediatric choroid plexus tumors (CPTs) remained limited. This study employed data mining and bioinformatics analysis to investigate the DNA methylation status of ZIC4 in CPTs and its correlation with patient survival. Our results unveiled ZIC4 methylation as a segregating factor, dividing CPT cohorts into two clusters, with hyper-methylation linked to adverse prognosis. Hyper-methylation of ZIC4 was confirmed in a choroid plexus carcinoma-derived cell line (CCHE-45) by bisulfite sequencing. Furthermore, our study demonstrated that demethylating agent and a histone methyltransferase inhibitor could reverse ZIC4 silencing. RNA sequencing and proteomic analysis showed that ZIC4 over-expression influenced genes and proteins involved in immune response, antigen processing and presentation, endoplasmic reticulum stress, and metabolism. Functionally, re-expressing ZIC4 negatively impacted cell proliferation and migration. Ultimately, these findings underscore ZIC4 hyper-methylation as a prognostic marker in CPTs and shed light on potential mechanisms underlying its tumor suppressor role in CPC. This insight paves the way for novel therapeutic targets in treating aggressive CPTs.
Selective-wavelength perfect infrared absorption in Ag@ZnO conical metamaterial structure
Authors: Faisal Muhammad , Ur Rahman Atta , Khan Sajid , Siyaf Muhammad , Shah Tawaf Ali , Okla Mohammad K. , Bourhia Mohammed , Younous Youssouf Ali 
Published: September 2024

AbstractWe present a new selective Metamaterial Perfect Absorber (MPA) consisting of zinc oxide embedded silver (Ag@ZnO), designed for applications in infrared stealth technology. The numerical simulation included a wide frequency range from 1 to 1000 THz and shows that the design MPA structure presented two absorption peaks at the desired wavelengths of 1.7 µm and 6.5 µm. The absorptivity of both peaks reached approximately 93.1% and 93.5%. The first peak at 1.7 µm decreases the scattering of IR laser beams from the surface of the MPA structure and also lowers the infrared tracks that could direct laser-guided devices to its specific target. On the other hand, the second peak reduces the surface heat wave. The suggested MPA (Ag@ZnO) structure is activated by a plane wave using a full wave vector and a broad frequency domain solution. In the framework of computer simulation technology (CST) Microwave Studio, uses both Finite-Difference-Time-Domain (FDTD) and Finite-Element-Method (FEM) techniques to predict the optical behavior of the proposed MPA structure. Both peaks achieved a high value of absorptivity due to the simultaneous excitation of the electric and magnetic dipole at resonance wavelength.
Breast-torso movement coordination during running in different breast support
Authors: Williams Genevieve K. R. , Reeves Jo , Vicinanza Domenico , Mills Chris , Jones Brogan , Wakefield-Scurr Joanna 
Published: September 2024

AbstractTo reduce breast motion with a bra, we need to understand what drives the motion of the breasts, and what variables change as support increases. Quantifying breast-torso coordination and movement complexity across the gait cycle may offer deeper insights than previously reported discrete time lag. We aimed to compare breast-torso coordination and mutual influence across breast support conditions during running. Twelve female participants ran on a treadmill at 10 km h−1 with an encapsulation and compression sports bra, and in no bra. Nipple and torso position was recorded. Vector coding, granger causality and transfer entropy were calculated within gait cycles. In both bra conditions, a greater percentage of gait cycles was spent with the breast and torso in-phase (> 90%) compared to no bra running (~ 66%, p < 0.001), with most time spent in-phase in the encapsulation versus compression bra (p = 0.006). There was a main effect of breast support condition on Granger causality (p < 0.001), both from breast to torso and torso to breast. Transfer of information was highest from torso to breast, compared to breast to torso in all conditions. Overall, these results provide novel insight into the mutual and complex interaction between the breast and the torso while running in different bra conditions. The approaches presented allow for a greater understanding of bra support conditions than existing discrete measures, which may relate to comfort and performance. Therefore, measures of coupling, predictability and transfer of complexity should be employed in future work examining these features.
Between two worlds: the scientist’s dilemma in climate activism
Authors: Finnerty Samuel , Piazza Jared , Levine Mark 
Published: September 2024

AbstractEnvironmental activism presents an ideological dilemma for environmentally concerned scientists, who must balance traditional scientific values of objectivity and impartiality with the urgency of the climate and ecological crisis. This paper presents a critical discursive analysis of interviews with 27 scientists from 11 countries. It details the linguistic repertoires scientists draw on and the subject positions adopted to manage this dilemma. We observed that scientists employ two strategies to reconcile their professional identities with their activism: redefining the scientist identity, and reframing the work that scientists do. The subject positions adopted broadly serve to legitimize action, such as arguing that activism as a scientist is objective and rational, or that being a scientist conveys a moral duty to advocate for scientific information. By analyzing how scientists negotiate conflicting identities and values, this research offers valuable insights into fostering informed decision-making and action in addressing urgent environmental challenges.
Frequency and Universal Principles in the Acquisition of Word-Initial Consonant Clusters in Palestinian Arabic
Authors: Watad Ola , Bat-El Foux Outi , Ben-David Avivit 
Published: September 2024

Purpose:

In this article, we present the results of our study on the acquisition of word-initial consonant clusters in Palestinian Arabic. The remarkable property of word-initial clusters in Palestinian Arabic is that they often violate the Sonority Sequencing Principle, a universal constraint that disfavors sonority fall (e.g.,
lba:n
“gum”) and, to a lesser degree, sonority plateau (e.g.,
kta:b
“book”). Given the violation of the Sonority Sequencing Principle, the acquisition of word-initial consonant clusters serves as a fruitful ground for studying the interaction of universal principles and language-specific effects. The goal of the study was to shed light on the role of universal principles in language acquisition and how they interact with frequency.

Method:
We carried out picture naming and sentence completion tasks with 60 monolingual and monodialectal children aged 2;00–5;00 (years;months), equally divided into six age groups. In addition, we built a small corpus of child-directed speech (CDS) to evaluate the distribution of the three sonority profiles of word-initial consonant clusters—rise, plateau, and fall.

Results:

We found a major language-specific effect in the cluster simplification strategies, with prothesis being the most common strategy (e.g.,
lbá:n
→
ilbá:n
“gum”). However, this effect was not found in the youngest group (2;00–2;05), where the cross-linguistically favorite strategy of C-deletion was most common (e.g.,
lbá:n
→
bá:n
“gum”). We also found a major effect of the Sonority Sequencing Principle in the children's productions, contrary to insignificant differences in CDS.

Conclusions:
Our study supports the claim that language acquisition is affected by both language-specific effects and universal principles. As for the interaction of these factors, we show that the effect of universal principles emerges under two conditions: (a) in early speech (youngest age group), before children accumulate sufficient data that allow language-specific properties to override, and/or (b) when frequency does not play a role.
Logos-Rationalität und die vergessenen Dimensionen der
Homöopathie
Authors: Schmidt Josef M. 
Published: September 2024

ZusammenfassungWährend sich die Auseinandersetzung um die Homöopathie heute zunehmend auf
quantitative Fragen verengt, wird hier eine qualitative (Wieder-)Eröffnung der 3
die Homöopathie konstituierenden Dimensionen vorgeschlagen, die alle auf
altehrwürdigen Denktraditionen beruhen (lógos, hómoion, iásthai). Die
Betrachtung ihrer Genealogien mag sich als erhellend erweisen für eine bessere
Einschätzung der Stärken und Schwächen der Homöopathie und modernen Medizin,
aber auch von neueren Entwicklungen in Gesellschaft, Kultur und Politik.