bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left Ventricular Function After Prolonged Exercise in Equine Endurance Athletes
Authors: Flethøj M. , Schwarzwald C.C. , Haugaard M.M. , Carstensen H. , Kanters J.K. , Olsen L.H. , Buhl R. 
Published: June 2016

BackgroundProlonged exercise in human athletes is associated with transient impairment of left ventricular (LV) function, known as cardiac fatigue. Cardiac effects of prolonged exercise in horses remain unknown.ObjectivesTo investigate the effects of prolonged exercise on LV systolic and diastolic function in horses.AnimalsTwenty‐six horses competing in 120–160 km endurance rides.MethodsCross‐sectional field study. Echocardiography was performed before and after rides, and the following morning, and included two‐dimensional echocardiography, anatomical M‐mode, pulsed‐wave tissue Doppler imaging, and two‐dimensional speckle tracking. Correlation between echocardiographic variables and cardiac troponin I was evaluated.ResultsEarly diastolic myocardial velocities decreased significantly in longitudinal (baseline: −17.4 ± 2.4cm/s; end of ride: −15.8 ± 3.2cm/s (P = .013); morning after: −15.4 ± 3.0cm/s (P = .0033)) and radial directions (−32.8 ± 3.4cm/s; −28.1 ± 5.8cm/s (P < .001); −26.4 ± 5.5cm/s (P < .001)). Early diastolic strain rates decreased significantly in longitudinal (1.58 ± 0.27s−1; 1.45 ± 0.26s−1 (P = .036); 1.41 ± 0.25s−1 (P = .013)) and circumferential directions (2.43 ± 0.29s−1; 1.96 ± 0.46s−1 (P < .001); 2.11 ± 0.32s−1 (P < .001)). Systolic variables showed ambiguous results. No correlations with serum cardiac troponin I concentrations were evident.Conclusions and Clinical ImportanceProlonged exercise in horses is associated with impaired LV diastolic function. Reduced ventricular filling persisted for 7–21 hours despite normalization of biochemical indicators of hydration status, indicating that the observed changes were not entirely related to altered preload conditions. The clinical relevance of cardiac fatigue in horses remains uncertain.
Incremental Value (Bayesian Framework) of Thoracic Ultrasonography over Thoracic Auscultation for Diagnosis of Bronchopneumonia in Preweaned Dairy Calves
Authors: Buczinski S. , Ménard J. , Timsit E. 
Published: June 2016

BackgroundThoracic ultrasonography (TUS) is a specific and relatively sensitive method to diagnose bronchopneumonia (BP) in dairy calves. Unfortunately, as it requires specific training and equipment, veterinarians typically base their diagnosis on thoracic auscultation (AUSC), which is rapid and easy to perform.Hypothesis/ObjectivesWe hypothesized that the use of TUS, in addition to AUSC, can significantly increase accuracy of BP diagnosis. Therefore, the objectives were to (i) determine the incremental value of TUS over AUSC for diagnosis of BP in preweaned dairy calves and (ii) assess diagnostic accuracy of AUSC.AnimalsTwo hundred and nine dairy calves (<1 month of age) were enrolled in this cross‐sectional study.MethodsProspective cross‐sectional study. All calves from a veal calves unit were examined (independent operators) using the Wisconsin Calf Respiratory Scoring Criteria (CRSC), AUSC, and TUS. A Bayesian latent class approach was used to estimate the incremental value of AUSC over TUS (integrated discrimination improvement [IDI]) and the diagnostic accuracy of AUSC.ResultsAbnormal CRSC, AUSC, and TUS were recorded in 3.3, 53.1, and 23.9% of calves, respectively. AUSC was sensitive (72.9%; 95% Bayesian credible interval [BCI]: 50.1–96.4%), but not specific (53.3%; 95% BCI: 43.3–64.0%) to diagnose BP. Compared to AUSC, TUS was more specific (92.9%; 95% BCI: 86.5–97.1%), but had similar sensitivity (76.5%; 95% BCI: 60.2–88.8%). The incremental value of TUS over AUSC was high (IDI = 43.7%; 5% BCI: 22.0–63.0%) significantly improving proportions of sick and healthy calves appropriately classified.Conclusions and Clinical ImportanceThe use of TUS over AUSC significantly improved accuracy of BP diagnosis in dairy calves.
Longitudinal Study of the Relationship among Craniocervical Morphology, Clinical Progression, and Syringomyelia in a Cohort of Cavalier King Charles Spaniels
Authors: Cerda‐Gonzalez S. , Olby N.J. , Griffith E.H. 
Published: June 2016

BackgroundCraniocervical junction (CCJ) anomalies and secondary syringomyelia are commonly diagnosed in Cavalier King Charles spaniel (CKCS). Familiarity with the natural history of these abnormalities is vital to understanding the disease syndrome.ObjectiveTo evaluate magnetic resonance imaging (MRI) predictors of worsening clinical signs, syringomyelia, and morphology in CKCS longitudinally.AnimalsFifty‐four client‐owned CKCS, 5–13 years old; 50% currently symptomatic.MethodsLongitudinal observational study. We enrolled CKCS with an MRI of the CCJ performed ≥3 years earlier. We used questionnaires and neurologic examinations to grade initial and current clinical status. Dogs that could be anesthetized were reimaged. Morphologic assessments included the presence and severity of: Chiari‐like malformations, medullary position, atlantooccipital overlapping (AOO), dorsal atlantoaxial bands, and syringomyelia. Cranial cavity volumes and foramen magnum height were measured.ResultsClinical status was evaluated in 54 dogs; 36/54 were reimaged. Mean follow‐up was 71 months. Of initially asymptomatic dogs, 32% were symptomatic at re‐evaluation. Of initially symptomatic dogs, 56% had worsened; 13% had improved with medical management. The morphology of the CCJ at initial imaging did not predict development of either new or worsened signs or syringomyelia by the time of re‐evaluation.ConclusionCraniocervical junction anomalies assessed in this study did not appear predictive of future clinical status or syringomyelia in our cohort. The impacts of syringomyelia, AOO, and atlantoaxial bands on future clinical status merit further study in larger groups of CKCS. Clinical progression in our cohort of medically managed CKCS did not differ substantially from published reports of those treated surgically.
Traditional and cyberbullying co‐occurrence and its relationship to psychiatric symptoms
Authors: Tural Hesapcioglu Selma , Ercan Filiz 
Published: June 2016

AbstractBackgroundThe effect of cyberbullying accompanied by traditional bullying on mental health has been less studied. In this study, the frequency, co‐occurrence, and the relationship to psychiatric symptoms of traditional bullying and cyberbullying among bullies and victims are examined.MethodsAll of the high schools in the province of Mus, Turkey were stratified according to Placement Test for High Schools admission points for 2014–2015. By choosing schools using simple random sampling, 1276 students were reached. Students were given the Brief Symptom Inventory and three separate scale assessments: peer bullying rating, cybervictimization, and cyberbullying scales.ResultsHigh scores in all subscale scores of bullying and victimization were significantly related to higher depression, anxiety, low self‐esteem, somatization, and hostility scores. For people who were exposed to cyberbullying in addition to traditional bullying, the severity of the psychiatric symptoms was significantly higher. For all psychiatric symptoms, major predictors were gender, total victimization score, and total cybervictimization score. Moreover, the bullying total score was among the predictors of low self‐esteem and hostility.ConclusionCybervictimization and cyberbullying occur less often than traditional bullying and victimization, but people who were exposed to or performed cyberbullying were also exposed to or performed traditional bullying. The addition of cyberbullying to traditional bullying is associated with more intense psychiatric symptoms.
Delayed extinction fails to reduce skin conductance reactivity to fear‐conditioned stimuli
Authors: Fricchione Jon , Greenberg Mark S. , Spring Justin , Wood Nellie , Mueller‐Pfeiffer Christoph , Milad Mohammed R. , Pitman Roger K. , Orr Scott P. 
Published: June 2016

AbstractA brief 10‐min time delay between an initial and subsequent exposure to extinction trials has been found to impair memory reconsolidation in fear‐conditioned rodents and humans, providing a potential means to reduce fearfulness in anxiety disorders and posttraumatic stress disorder (PTSD). The present study used videos of biologically prepared, conditioned stimuli (tarantulas) to test the efficacy of delayed extinction in blocking reconsolidation of conditioned fear in healthy young adults. Strong differential conditioning, measured by skin conductance, was observed among a screened subset of participants during acquisition. However, the delayed‐extinction intervention failed to reduce reactivity to the conditioned stimulus paired with the extinction delay. These results are partially consistent with other recent, mixed findings and point to a need for testing other candidate interventions designed to interfere with the reconsolidation process.
Association of daytime sleepiness with obstructive sleep apnoea and comorbidities varies by sleepiness definition in a population cohort of men
Authors: Adams Robert J. , Appleton Sarah L. , Vakulin Andrew , Lang Carol , Martin Sean A. , Taylor Anne W. , McEvoy R. Doug , Antic Nick A. , Catcheside Peter G. , Wittert Gary A. 
Published: June 2016

AbstractBackground and objectiveTo determine correlates of excessive daytime sleepiness (EDS) identified with the Epworth Sleepiness Scale (ESS) and a more broad definition, while accounting for obstructive sleep apnoea (OSA) in community dwelling men.MethodsParticipants of the Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) Study (n = 837, ≥ 40 years) without a prior OSA diagnosis, underwent in‐home full unattended polysomnography (PSG, Embletta X100), completed the ESS, STOP questionnaire and Pittsburgh Sleep Quality Index in 2010–2011. In 2007–2010, questionnaires and biomedical assessment (in South Australian public hospital‐based clinics) identified medical conditions. An alternate EDS definition (EDSAlt) consisted of ≥ 2 of 3 problems (feeling sleepy sitting quietly; feeling tired/fatigued/sleepy; trouble staying awake).ResultsEDSAlt (30.4%, n = 253), but not ESS ≥ 11 (EDSESS, 12.6%, n = 104), increased significantly across OSA severity and body mass index categories. In adjusted analyses, EDSESS was significantly associated with depression: odds ratio (OR), 95%CI: 2.2 (1.3–3.8) and nocturia: 2.0 (1.3–3.2). EDSAlt was associated with depression, financial stress, relationship, work‐life balance problems and associations with nocturia and diabetes were borderline. After excluding men with EDSESS, EDSAlt was associated with oxygen desaturation index (3%) ≥ 16 and the highest arousal index quartile but not with comorbidities.ConclusionSleepiness not necessarily leading to dozing, but not ESS ≥ 11, was related to sleep disordered breathing. Clinicians should be alert to (1) differing perspectives of sleepiness for investigation and treatment of OSA, and (2) the presence of depression and nocturia in men presenting with significant Epworth sleepiness regardless of the presence of OSA.
International Trade in General Oligopolistic Equilibrium
Authors: Neary J. Peter 
Published: June 2016

AbstractThis paper presents a new model of oligopoly in general equilibrium and explores its implications for positive and normative aspects of international trade. Assuming “continuum–Pollak” preferences, the model allows for consistent aggregation over a continuum of sectors, in each of which a small number of home and foreign firms engage in Cournot competition. I show how competitive advantage interacts with comparative advantage to determine resource allocation and, specializing to continuum–quadratic preferences, I explore the model's implications for the gains from trade, for the distribution of income between wages and profits, and for production and trade patterns in a two‐country world.
Association of Low Ficolin–Lectin Pathway Parameters with Cardiac Syndrome X
Authors: Horváth Z. , Csuka D. , Vargova K. , Leé S. , Varga L. , Garred P. , Préda I. , Zsámboki E. T. , Prohászka Z. , Kiss R. G. 
Published: June 2016

AbstractIn patients with typical angina pectoris, inducible myocardial ischaemia and macroscopically normal coronaries (cardiac syndrome X (CSX)), a significantly elevated plasma level of terminal complement complex (TCC), the common end product of complement activation, has been observed without accompanying activation of the classical or the alternative pathways. Therefore, our aim was to clarify the role of the ficolin–lectin pathway in CSX. Eighteen patients with CSX, 37 stable angina patients with significant coronary stenosis (CHD) and 54 healthy volunteers (HC) were enrolled. Serum levels of ficolin‐2 and ficolin‐3, ficolin‐3/MASP‐2 complex and ficolin‐3‐mediated TCC deposition (FCN3‐TCC) were determined. Plasma level of TCC was significantly higher in the CSX than in the HC or CHD group (5.45 versus 1.30 versus 2.04 AU/ml, P < 0.001). Serum levels of ficolin‐2 and ficolin‐3 were significantly lower in the CSX compared to the HC or CHD group (3.60 versus 5.80 or 5.20 μg/ml, P < 0.05; 17.80 versus 24.10 or 26.80 μg/ml, P < 0.05). The ficolin‐3/MASP‐2 complex was significantly lower in the CSX group compared to the HC group (92.90 versus 144.90 AU/ml, P = 0.006). FCN3‐TCC deposition was significantly lower in the CSX group compared to the HC and CHD groups (67.8% versus 143.3% or 159.7%, P < 0.05). In the CSX group, a significant correlation was found between TCC and FCN3‐TCC level (r = 0.507, P = 0.032) and between ficolin‐3/MASP‐2 complex level and FCN3‐TCC deposition (r = 0.651, P = 0.003). In conclusion, in patients with typical angina and myocardial ischaemia despite macroscopically normal coronary arteries, low levels of several lectin pathway parameters were observed, indicating complement activation and consumption. Complement activation through the ficolin–lectin pathway might play a role in the complex pathomechanism of CSX.
‘Shut Up for Five Years’: Locating Narratives of Cultural Workers in Scotland's Islands
Authors: Burnett Kathryn A. , Stalker Lynda Harling 
Published: June 2016

AbstractRecent research and active promotion suggests that islands and remote rural locations in Scotland do offer ‘attractive places to live and work’. The purpose of this article is to explore the narratives of cultural workers, and to derive from this a further nuanced appreciation of what in‐migrants to islands might express as meaningful in reference to an idea of ‘locating narratives’. We look at how the narratives vary depending upon the connection and identity the cultural workers each articulate. The narratives or social stories the participants tell contribute to our understanding of in‐migrants' experiences on remote islands. This research offers a timely contribution to debates on how we might better understand ‘good work’ in terms of decisions to locate on islands, as nuanced through cultural work identities.
An Al‐inducible expansin gene,OsEXPA10is involved in root cell elongation of rice
Authors: Che Jing , Yamaji Naoki , Shen Ren Fang , Ma Jian Feng 
Published: June 2016

SummaryExpansins are cell wall loosening proteins, which are encoded by multigene families. However, the physiological role of most expansin genes is still poorly understood. Here, we functionally characterized an Al‐inducible expansin gene,OsEXPA10, which is regulated by a C2H2‐type zinc‐finger transcription factor,ART1 in rice. A detailed expression analysis showed thatOsEXPA10was expressed in both the roots and shoots at a similar level, but only the expression in the roots was rapidly upregulated in response to Al. Furthermore, spatial expression analysis showed that the Al‐induced expression was only found in the root tips (0–3 mm), but not in the mature root zones. The expression was neither induced by other metals including Cd and La nor by lowpH. Immunostaining showed that OsEXPA10 was localized at all cells of the root tips. Knockout ofOsEXPA10resulted in a significant decrease in the cell elongation of the roots in the absence of Al. In the presence of Al, knockout ofOsEXPA10did not alter the Al sensitivity evaluated by relative root elongation, but the root cell wall of knockout lines accumulated less Al compared to those of the wild‐type rice. Collectively, our results indicate thatOsEXPA10expressed in the root tips is required for the root cell elongation, but that the contribution of this gene to high Al tolerance in rice is small.
Transfusion premedication practices among pediatric health care practitioners in Canada: results of a national survey
Authors: Solh Ziad , Chan Anthony K. C. , Heddle Nancy M. 
Published: June 2016

BACKGROUNDAlthough not supported by strong evidence, premedication (pretransfusion medication) is commonly prescribed to patients who have had a transfusion reaction. The research questions were: 1) What are Canadian pediatric practitioners' views and practices regarding premedication and 2) what are barriers to reducing premedication overuse in pediatrics?STUDY DESIGN AND METHODSAn online survey targeted hematology/oncology, emergency medicine, general surgery, intensive care, and cardiac intensive care practitioners in all 16 Canadian pediatric tertiary hospitals. The survey included four sections: demographic, clinical, future directions, and organizational questions.RESULTSFifty‐five individuals from 15 of 16 pediatric tertiary care sites completed the survey: 53 physicians and two nurse practitioners. More than half of the respondents (55%; 30/55) were pediatric hematology/oncology providers, and 35% (19/55) were directors of their respective divisions. Eighty‐seven percent of respondents estimated that they premedicate up to 25% of red blood cell (RBC) transfusions, and 13% premedicate 26% to 50% RBC transfusions. Proportions were similar for platelet transfusions. Most respondents reported that trainees are involved in transfusion and premedication order decisions. Seven percent believe that their hospital does not use leukoreduction and 27% are not sure. Sixty‐five percent of respondents were not aware of a clinical practice guideline or a standard order set (SOS) at their institution: 51% are interested in having both available. Factors influencing the decision to premedicate and barriers to change were identified.CONCLUSIONPremedication practices are variable in Canadian pediatric academic hospitals. Evidence‐based premedication clinical practice guidelines and SOS could be explored as a way to standardize practices. There were perceived educational and institutional barriers to practice change.
In vivo methods to evaluate a new skin protectant for loss of skin integrity
Authors: Been Raha A. , Bernatchez Stéphanie F. , Conrad‐Vlasak Deena M. , Asmus Robert A. , Ekholm Bruce P. , Parks Patrick J. 
Published: June 2016

ABSTRACTA new skin protectant was developed for use on conditions involving partial‐thickness skin loss such as severe incontinence‐associated dermatitis. This new formulation is based on a cyanoacrylate chemistry designed to polymerize in situ and create a breathable film able to protect the skin surface from external irritants. This film provides an environment favorable for healing to occur beneath the film. To evaluate the characteristics of the novel chemistry, we devised a preclinical testing strategy comprising three different animal models. The data from all three models was considered collectively to create an overall assessment of effectiveness. A guinea pig model was used to evaluate the barrier efficacy of the new product in protecting intact skin from irritation. A porcine partial‐thickness wound model was used to evaluate the efficacy of the product in helping control minor bleeding and exudate. A similar model was also used to assess the process of reepithelialization in the continued presence of an irritant. In the first model, untreated sites had 8.5 times more irritation than sites covered with the new product (p < 0.001). In the second model, a single application of the new product successfully attached to intact peri‐wound skin and to denuded, weepy skin. It significantly reduced the amount of fluid weeping from the wounds (p ≤ 0.001) and continued to perform throughout a 96 hours experiment. In the third model, the percent of reepithelialization was significantly greater for the wounds covered with the new product than for the control wounds (p = 0.003; on average, 18.3% greater, with a 95% confidence interval of 9.2% to 27.5%). These results suggest that the new skin protectant protects intact and denuded skin from irritants and provides an environment favorable to healing, offering promise for the management of various conditions involving loss of epidermis.
Complete Genome Sequence of Bacteriophage Deep-Blue Infecting Emetic Bacillus cereus
Authors: Hock Louise , Gillis Annika , Mahillon Jacques 
Published: June 2016

ABSTRACT

The
Bacillus cereus
emetic pathotype is responsible for important food-borne intoxications. Here, we describe the complete genome sequence of bacteriophage Deep-Blue, which is able to infect emetic strains of
B. cereus
. Deep-Blue is a 159-kb myophage of the Bastille-like group within the
Spounavirinae
.
Outbreak of H7N8 Low Pathogenic Avian Influenza in Commercial Turkeys with Spontaneous Mutation to Highly Pathogenic Avian Influenza
Authors: Killian Mary Lea , Kim-Torchetti Mia , Hines Nichole , Yingst Sam , DeLiberto Thomas , Lee Dong-Hun 
Published: June 2016

ABSTRACT
Highly pathogenic avian influenza (HPAI) subtype H7N8 was detected in commercial turkeys in January 2016. Control zone surveillance discovered a progenitor low pathogenic avian influenza (LPAI) virus in surrounding turkey flocks. Data analysis supports a single LPAI virus introduction followed by spontaneous mutation to HPAI on a single premises.
Draft Genome Sequence of “
Rathayibacter tanaceti
” Strain VKM Ac-2596 Isolated from
Tanacetum vulgare
Infested by a Foliar Nematode
Authors: Vasilenko Oleg V. , Starodumova Irina P. , Tarlachkov Sergey V. , Dorofeeva Lubov V. , Avtukh Alexander N. , Evtushenko Lyudmila I. 
Published: June 2016

ABSTRACT

The draft genome of “
Rathayibacter tanaceti
” VKM Ac-2596 is 3.17 Mb in size with an average G+C content of 70.7% and comprises at least two nonidentical copies of ribosomal small subunit (SSU-rRNA) genes. The semiconductor sequencing platform Ion Torrent was used.
Draft Genome Sequence of a Copper-Resistant Marine Bacterium, Pantoea agglomerans Strain LMAE-2, a Bacterial Strain with Potential Use in Bioremediation
Authors: Corsini Gino , Valdés Natalia , Pradel Paulina , Tello Mario , Cottet Luis , Muiño Laura , Karahanian Eduardo , Castillo Antonio , Gonzalez Alex R. 
Published: June 2016

ABSTRACT

Pantoea agglomerans
LMAE-2 was isolated from seabed sediment moderately contaminated with Cu
2+
. Here, we report its draft genome sequence, which has a size of 4.98 Mb. The presence of
cop
genes related with copper homeostasis in its genome may explain the resistance and strengthen its potential for use as bioremediation agent.
Complete Chloroplast Genome Sequence of Phagomixotrophic Green Alga
Cymbomonas tetramitiformis
Authors: Satjarak Anchittha , Paasch Amber E. , Graham Linda E. , Kim Eunsoo 
Published: June 2016

ABSTRACT

We report here the complete chloroplast genome sequence of
Cymbomonas tetramitiformis
strain PLY262, which is a prasinophycean green alga that retains a phagomixotrophic mode of nutrition. The genome is 84,524 bp in length, with a G+C content of 37%, and contains 3 rRNAs, 26 tRNAs, and 76 protein-coding genes.