bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of radiative heat transfer parameters in multilayer thermal insulation of spacecraft
Authors: Nenarokomov Aleksey V. , Dombrovsky Leonid A. , Krainova Irina V. , Alifanov Oleg M. , Budnik Sergey A. 
Published: April 2017

Purpose
The purpose of this study is to optimize multilayer vacuum thermal insulation (MLI) of modern high-weight spacecrafts. An adequate mathematical simulation of heat transfer in the MLI is impossible if there is no available information on the main insulation properties.

Design/methodology/approach
The results of experiments in thermo-vacuum facilities are used to re-estimate some radiative properties of metallic foil/metalized polymer foil and spacer on the basis of the inverse problem solution. The experiments were carried out for the sample of real MLI used for the BP-Colombo satellite (ESA). The recently developed theoretical model based on neglecting possible near-field effects in radiative heat transfer between closely spaced aluminum foils was used in theoretical predictions of heat transfer through the MLI.

Findings
A comparison of the computational results and the experimental data confirms that there are no significant near-field effects between the neighboring MLI layers. It means that there is no considerable contradiction between the far-field model of radiative transfer in MLI and the experimental estimates.

Originality/value
An identification procedure for mathematical model of the multilayer thermal insulation showed that a modified theoretical model developed recently can be used to estimate thermal properties of the insulation at conditions of space vacuum.
Legislation impact on sick leave in Slovakia
Authors: Blazinska Lucia , Rusnak Martin , Kacmarikova Margareta 
Published: April 2017

PurposeSickness absence is a major public health and economic problem. The purpose of this paper is to evaluate the effects of a legislative intervention that concerns reduction of compensation levels in sickness absence in the Slovak Republic. In addition, the study encompasses appraisal of effects reflected by related indicators.Design/methodology/approachThe paper describes an evaluation study, based on national statistics from relevant sources. Numeric data were used for characterizing the dynamics of sickness absence in Slovakia in the years 1997-2013. Statistical programmes join-point and R-environment were used for analytical purposes in terms of Wilcoxon test and linear regression.FindingsThe results suggest that following the implementation of the Act No. 462/2003 Coll. the number of new cases as well as the proportion of sickness absence among insured persons decreased by 50 per cent (from 2003 – 60/100 to 2004 – 30,8/100). Average duration of inability to work increased to 6.5 days and there were more women compared to men on sick leave. The most frequent causes of sickness absence were respiratory diseases, muscular-skeletal diseases and injuries outside the workplace.Research limitations/implicationsThe trend of sickness absence can be influenced by many others factors, but the research is mainly focussed on legislative impact.Originality/valueThe research indicates an effect of legislative intervention at national level.
A network of networks
Authors: Iedema Rick , Verma Raj , Wutzke Sonia , Lyons Nigel , McCaughan Brian 
Published: April 2017

Purpose
To further our insight into the role of networks in health system reform, the purpose of this paper is to investigate how one agency, the NSW Agency for Clinical Innovation (ACI), and the multiple networks and enabling resources that it encompasses, govern, manage and extend the potential of networks for healthcare practice improvement.

Design/methodology/approach
This is a case study investigation which took place over ten months through the first author’s participation in network activities and discussions with the agency’s staff about their main objectives, challenges and achievements, and with selected services around the state of New South Wales to understand the agency’s implementation and large system transformation activities.

Findings
The paper demonstrates that ACI accommodates multiple networks whose oversight structures, self-organisation and systems change approaches combined in dynamic ways, effectively yield a diversity of network governances. Further, ACI bears out a paradox of “centralised decentralisation”, co-locating agents of innovation with networks of implementation and evaluation expertise. This arrangement strengthens and legitimates the role of the strategic hybrid – the healthcare professional in pursuit of change and improvement, and enhances their influence and impact on the wider system.

Research limitations/implications
While focussing the case study on one agency only, this study is unique as it highlights inter-network connections. Contributing to the literature on network governance, this paper identifies ACI as a “network of networks” through which resources, expectations and stakeholder dynamics are dynamically and flexibly mediated and enhanced.

Practical implications
The co-location of and dynamic interaction among clinical networks may create synergies among networks, nurture “strategic hybrids”, and enhance the impact of network activities on health system reform.

Social implications
Network governance requires more from network members than participation in a single network, as it involves health service professionals and consumers in a multi-network dynamic. This dynamic requires deliberations and collaborations to be flexible, and it increasingly positions members as “strategic hybrids” – people who have moved on from singular taken-as-given stances and identities, towards hybrid positionings and flexible perspectives.

Originality/value
This paper is novel in that it identifies a critical feature of health service reform and large system transformation: network governance is empowered through the dynamic co-location of and collaboration among healthcare networks, particularly when complemented with “enabler” teams of people specialising in programme implementation and evaluation.
Branding capabilities and SME performance in an emerging market
Authors: Odoom Raphael , Agbemabiese George Cudjoe , Anning-Dorson Thomas , Mensah Priscilla 
Published: April 2017

Purpose
The purpose of this paper is to test the effect of brand regulations on the relationship between enterprises’ branding capabilities (internal and external) and performance. It also examines the hypothesized relationship effects across manufacturing and service-based enterprises.

Design/methodology/approach
The study uses data from 384 small- and medium-sized enterprises (SMEs) within an emerging market setting. Moderated hierarchical regression was used to examine the theoretical interrelationships between branding capabilities and enterprise performance within the boundaries of regulations.

Findings
Results from the study suggest that both internal and external branding capabilities positively affect enterprise performance. However, the effect is confounded as brand regulations attenuate the relationship between enterprises’ branding capabilities and performance. Varying outcomes across manufacturing and service-based enterprises are also assessed.

Originality/value
The study suggests that policy makers should review regulations on businesses, particularly those relating to the small business sector. Regulations that ameliorate activities of SMEs should be implemented to promote existing enterprises, and attract new ones for industrialization in emerging markets. The findings provide evidence for issues of potential research and managerial interest, with implications for both policy makers, small business owners and the academic community.
LRFMP model for customer segmentation in the grocery retail industry: a case study
Authors: Peker Serhat , Kocyigit Altan , Eren P. Erhan 
Published: April 2017

Purpose
The purpose of this paper is to propose a new RFM model called length, recency, frequency, monetary and periodicity (LRFMP) for classifying customers in the grocery retail industry; and to identify different customer segments in this industry based on the proposed model.

Design/methodology/approach
This study combines the LRFMP model and clustering for customer segmentation. Real-life data from a grocery chain operating in Turkey is used. Three cluster validation indices are used for optimizing the number of groups of customers and K-means algorithm is employed to cluster customers. First, attributes of the LRFMP model are extracted for each customer, and then based on LRFMP model features, customers are segmented into different customer groups. Finally, identified customer segments are profiled based on LRFMP characteristics and for each customer profile, unique CRM and marketing strategies are recommended.

Findings
The results show that there are five different customer groups and based on LRFMP characteristics, they are profiled as: “high-contribution loyal customers,” “low-contribution loyal customers,” “uncertain customers,” “high-spending lost customers” and “low-spending lost customers.”

Practical implications
This research may provide researchers and practitioners with a systematic guideline for effectively identifying different customer profiles based on the LRFMP model, give grocery companies useful insights about different customer profiles, and assist decision makers in developing effective customer relationships and unique marketing strategies, and further allocating resources efficiently.

Originality/value
This study contributes to prior literature by proposing a new RFM model, called LRFMP for the customer segmentation and providing useful insights about behaviors of different customer types in the Turkish grocery industry. It is also precious from the point of view that it is one of the first attempts in the literature which investigates the customer segmentation in the grocery retail industry.
Financial conditions and corporate investment: evidence from Vietnam
Authors: Tran Nam Hoai , Le Chi Dat 
Published: April 2017

Purpose
This study aims to investigate the influence of macro-financial conditions on firm-level capital allocation as a micro-transmission mechanism of monetary policy in Vietnam.

Design/methodology/approach
The authors employ a dynamic model of investment based on the Euler equation approach that allows for financial frictions. The financial conditions are proxied by a composite index of the current states of financial variables, including interest rates, exchange rates, stock prices, and credit demand – which captures short-term shocks in monetary transmission channels. Corporate financing constraints, as a reflection of financial frictions, are measured by the sensitivity of investment to internal funds, which are extensively examined in terms of both negative and positive cash flows.

Findings
In the presence of a non-monotonic (or U-shaped) investment–cash flow relation, the empirical evidence from Vietnamese listed firms indicates that financial conditions affect investment behavior for only firms with negative cash flows, in the sense that better financial conditions alleviate the level of “negative” financing constraints (i.e. the sensitivity of investment to negative cash flow). This effect is greater for larger firms and more likely pronounced for firms without state ownership.

Originality/value
This study contributes to the literature on corporate financing constraints in a manner of considering the macroeconomic dimension, specifically exploring the asymmetric impacts of financial conditions on the investment sensitivity to cash flow.
Does corporate governance shape the relationship between corporate social responsibility and financial performance?
Authors: Kabir Rezaul , Thai Hanh Minh 
Published: April 2017

PurposeThe theoretical and empirical relationships between corporate social responsibility (CSR) and corporate financial performance are not without controversy. Yet, CSR activities are increasingly undertaken by a large number of firms, not only in developed countries but also in emerging countries. This paper aims to investigate the moderating effect of different aspects of corporate governance, which are foreign and state ownership, board size and board independence, on the relationship between CSR and financial performance.Design/methodology/approachA sample of Vietnamese listed firms is analyzed. Robust regression analysis is performed using ordinary least squares as well as fixed-effects and two-stage least squares model.FindingsOrdinary least squares regression results show that CSR activities affect the financial performance of firms positively. Furthermore, corporate governance features like foreign ownership, board size and board independence strengthen the positive relationship between CSR and financial performance, but there is no such impact of state ownership.Originality/valuePrevious studies mostly investigate the direct effect of CSR on financial performance. A few studies examine the moderating effect of corporate governance, which is ownership concentration and board gender diversity. As an emerging country, Vietnam has some specific characteristics on corporate governance. This paper contributes by investigating the moderating effect of few major aspects of corporate governance, which are foreign and state ownership, board size and board independence.
Exploring local vs global brand associations in an emerging market using BCM technique
Authors: Eren-Erdoğmuş İrem , Dirsehan Taşkın 
Published: April 2017

Purpose
The purpose of this paper is to differentiate local versus global brand associations in an emerging market (Turkey)’s coffee shop market.

Design/methodology/approach
Two leading coffee shop brands – one local and one global – were analyzed with an emerging exploratory research technique – brand concept mapping (BCM) – to reveal their strong, favorable and unique associations leading them to market leadership.

Findings
The results indicate that, these two successful brands both have distinctive, yet relevant positions in their consumers’ mind. Local cultural experience is relevant for differentiating local brands, even if the coffee shop concept is globally imported. Global coffee shop brand, on the other hand, means membership to global middle income segment and is remembered as global fast coffee service.

Research limitations/implications
The main limitation of this exploratory study is the sample size limitation by its nature. So, the generalizability of the results should be approached with caution. Researchers use BCM technique; however, this method does not permit to reveal the expected levels and the importance of the attributes. Thus, further research are suggested to be complementary.

Originality/value
This study fills the research gap in revealing and comparing local vs global brand associations by using BCM technique, which enables one to measure the strength, unique and favorable associations/brand images more suitable to Keller’s (1993) conceptualization. This study pioneers in using this technique in international branding.
Neuroprotective effects of a novel poly (ADP‐ribose) polymerase‐1 inhibitor, JPI‐289, in hypoxic rat cortical neurons
Authors: Kim Youngchul , Kim Young S. , Noh Min‐Young , Lee Hanchang , Joe Boyoung , Kim Hyun Y. , Kim Jeongmin , Kim Seung H. , Park Jiseon 
Published: April 2017

SummaryExcessive activation of poly (ADP‐ribose) polymerase‐1 (PARP‐1) is known to develop neuronal apoptosis, necrosis and inflammation after ischaemic brain injury. Therefore, PARP‐1 inhibition after ischaemic stroke has been attempted in successful animal studies. The purpose of present work was to develop a novel water soluble PARP‐1 inhibitor (JPI‐289) and explore its neuroprotective effect on ischaemic injury in an in vitro model. The half‐life of JPI‐289 after intravenous or oral administration in rats was relatively long (1.4‐1.5 hours) with 65.6% bioavailability. The inhibitor strongly inhibited PARP‐1 activity (IC50=18.5 nmol/L) and cellular PAR formation (IC50=10.7 nmol/L) in the nanomolar range. In rat cortical neuronal cells, JPI‐289 did not affect cell viability up to 1 mmol/L as assayed by Trypan blue staining (TBS) and lactate dehydrogenase (LDH) assay. Treatment of JPI‐289 for 2 hours after 2 hours of oxygen glucose deprived (OGD) rat cortical neuron attenuated PARP activity and restored ATP and NAD+ levels. Apoptosis‐associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase‐3 were reduced after JPI‐289 treatment in the OGD model. The present findings suggest that the novel PARP‐1 inhibitor, JPI‐289, is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.
Unlocking the story in the swab: A new genotyping assay for the amphibian chytrid fungus Batrachochytrium dendrobatidis
Authors: Byrne Allison Q. , Rothstein Andrew P. , Poorten Thomas J. , Erens Jesse , Settles Matthew L. , Rosenblum Erica Bree 
Published: April 2017

AbstractOne of the most devastating emerging pathogens of wildlife is the chytrid fungus, Batrachochytrium dendrobatidis (Bd), which affects hundreds of amphibian species around the world. Genomic data from pure Bd cultures have advanced our understanding of Bd phylogenetics, genomic architecture and mechanisms of virulence. However, pure cultures are laborious to obtain and whole‐genome sequencing is comparatively expensive, so relatively few isolates have been genetically characterized. Thus, we still know little about the genetic diversity of Bd in natural systems. The most common noninvasive method of sampling Bd from natural populations is to swab amphibian skin. Hundreds of thousands of swabs have been collected from amphibians around the world, but Bd DNA collected via swabs is often low in quality and/or quantity. In this study, we developed a custom Bd genotyping assay using the Fluidigm Access Array platform to amplify 192 carefully selected regions of the Bd genome. We obtained robust sequence data for pure Bd cultures and field‐collected skin swabs. This new assay has the power to accurately discriminate among the major Bd clades, recovering the basic tree topology previously revealed using whole‐genome data. Additionally, we established a critical value for initial Bd load for swab samples (150 Bd genomic equivalents) above which our assay performs well. By leveraging advances in microfluidic multiplex PCR technology and the globally distributed resource of amphibian swab samples, noninvasive skin swabs can now be used to address critical spatial and temporal questions about Bd and its effects on declining amphibian populations.
Epigenetic regulation in monocyte/macrophage: A key player during atherosclerosis
Authors: Jia Su‐Jie , Gao Ke‐Qin , Zhao Ming 
Published: April 2017

SummaryAtherosclerosis is a chronic inflammatory disease. Recently, a growing body of evidence emphasizes that the monocyte and macrophage differentiation and activation are key processes in the development of atherosclerosis. However, the regulatory mechanism that manipulates the function of monocyte and macrophage is still unclear. Recent years, epigenetic mechanisms have received a wide attention and bring us a new field of vision. More and more evidence shows that epigenetics weighs heavily in atherosclerosis by regulating the function and differentiation states of monocyte and macrophage. In this review, we illuminate the epigenetic regulation mechanisms in monocyte and macrophage and their contributions to inflammatory processes of atherosclerosis to provide new thoughts and find novel targets or biomarkers for atherosclerosis.
Inflammasome gene profile is modulated in septic patients, with a greater magnitude in non-survivors
Authors: Esquerdo K F , Sharma N K , Brunialti M K C , Baggio-Zappia G L , Assunção M , Azevedo L C P , Bafi A T , Salomao R 
Published: April 2017

Summary
Inflammasome signalling induces the processing and secretion of interleukin (IL)-1β and IL-18 which, coupled with pyroptosis, activate further the inflammatory response. In the present study we evaluated the expression of genes involved in inflammasome signalling pathways in septic patients, their interaction networks and the predicted functions modulated in survivors and non-survivors. Twenty-seven patients with sepsis secondary to community-acquired pneumonia admitted to intensive care units from three general hospitals in São Paulo were included into the study. We performed a polymerase chain reaction (PCR) array encompassing 35 genes related to the nucleotide-binding oligomerization domain and leucine-rich repeat-containing (NLR)-inflammasome in peripheral blood mononuclear cells obtained at admission and after 7 days of follow-up. Eleven healthy volunteers were used as the reference group. Increased NLRC4 and NLRP3 and decreased nucleotide-binding oligomerization domain (NOD1), and NLRP1 expression was observed in septic patients compared to healthy individuals; the IL-1β and IL-18 expression levels were also high in the patients. The gene expression changes followed the same patterns in surviving and non-surviving patients, with higher magnitudes observed in non-survivors. Functional analyses revealed, however, that activation and inhibition intensity for representing functions were different in survivors and non-survivors, as for production of reactive oxygen species, synthesis of nitric oxide and for the control of bacterial infections. Our results showed that the genes involved in the activation of the NLR-inflammasome cascades were altered substantially in septic patients, with a higher number of altered genes and a higher intensity in the disturbance of gene expression found among patients dying of sepsis.
Medication adherence and rejection rates in older vs younger adult liver transplant recipients
Authors: Leven Emily A. , Annunziato Rachel , Helcer Jacqueline , Lieber Sarah R. , Knight Christopher S. , Wlodarkiewicz Catherine , Soriano Rainier P. , Florman Sander S. , Schiano Thomas D. , Shemesh Eyal 
Published: April 2017

AbstractA growing number of older adults are undergoing liver transplantation (LT) in the United States. In some settings, it is thought that adherence declines with age. This retrospective study examined adherence and clinical outcomes in older vs younger adult LT recipients. Medical records of adult LT recipients from 2009 to 2012 from a single urban center were reviewed. The medication level variability index (MLVI) was the predefined primary outcome, with nonadherence defined as MLVI >2.5. The secondary outcome was incidence of rejection. Outcomes were evaluated starting 1 year post‐LT until 2015. A total of 42 of 248 patients were ≥65 at transplant. Older adults had significantly better adherence than younger ones (65%≥65 were adherent vs 42% younger adults; chi‐square two‐tailed P=.02). Survival analyses of rejection between age groups censored by time since transplant showed no difference among the four age groups (χ2=0.84, P=.84). Older age was not found to be a risk factor for reduced adherence or graft rejection in patients surviving at least 1 year post‐LT.