bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approximation faible pour les 0-cycles sur un produit de variétés rationnellement connexes
Authors: LIANG YONGQI 
Published: March 2017

RésuméConsidérons l'approximation faible de 0-cycles sur une variété propre lisse définie sur un corps de nombres, elle est conjecturée d'étre contrôlée par le groupe de Brauer de la variété. Soit X une surface de Châtelet ou une compactification lisse d'un espace homogéne d'un groupe algébrique linéaire connexe à stabilisateur connexe. Soit Y une variété rationnellement connexe. Nous montrons que l'approximation faible de 0-cycles sur le produit X × Y est contrôlée par son groupe de Brauer si c'est le cas pour Y après toute extension finie du corps de base. Nous ne supposons l'existence de 0-cycles de degré 1 ni sur X ni sur Y.
Understanding adolescent personality pathology from growth trajectories of childhood oddity
Authors: De Clercq Barbara , Verbeke Lize , De Caluwé Elien , Vercruysse Tom , Hofmans Joeri 
Published: March 2017

AbstractResearch on developmental trajectories of early maladaptive features for understanding later personality disorders (PDs) is increasingly recognized as an important study area. The course of early odd features is highly relevant in this regard, as only a few researchers have addressed childhood oddity in the context of emerging PDs. Using latent growth modeling, the current study explores growth parameters of odd features in a mixed sample of Flemish community and referred children (N = 485) across three measurement waves with 1-year time intervals. Personality pathology was assessed at a fourth assessment point in adolescence. Beyond a general declining trend in oddity characteristics, the results demonstrated that both an early onset and an increasing trend of oddity-related characteristics over time are independent predictors of adolescent PDs. Childhood oddity tends to be the most manifest precursor for PDs with a core oddity feature (i.e., the schizotypal and borderline PD), but also appears to predict most of the other DSM-5 PDs. Results are discussed from an overarching developmental framework on PDs (Cicchetti, 2014), specifically focusing on the principle of multifinality. From a clinical perspective, the significance of increasing or steady-high childhood oddity trajectories for adolescent PDs highlights the relevance of systematic screening processes across time.
The Medical and the Musical: French Physiology and Late Nineteenth-Century Operatic Training
Authors: Francis Kimberly , Lachapelle Sofie 
Published: March 2017

AbstractIn 1892, physician Achille Gouguenheim (1839–1901) was invited to teach a course on the physiology and hygiene of singing at the Paris Conservatoire. By that time, scientists had been interested in the mechanics of the ‘invisible’ singing voice for years, initially experimenting on human and animal cadavers using strings and weights to make dead larynges sing. By mid-century, with the development of better quality artificial lighting and mirrors, physicians and physiologists finally developed a better understanding of the relationship between voice and physiology. Meanwhile, by 1890, a growing number of connoisseurs and medical professionals alike were concerned that there was a crisis ruining French operatic singing. Gouguenheim and others argued that the key to improving the situation rested on embedding medical knowledge and its relationship to the proper functioning of the larynx and voice into pedagogy at the Conservatoire. Drawing upon archival documents, debates in leading periodicals and Gouguenheim’s published lecture notes, we examine the marriage between medical science and artistic pedagogy during the latter part of the nineteenth century. Overall, we argue that this evidence reveals a strand of French vocal training that merged the fields of science and artistry, if ever so briefly, creating pedagogical methods that for a few years offered the promise of rescuing French opera performance.
The form of the monostrophic ballata as a frame for a logical demonstration
Authors: RIJK ELENA ABRAMOV-VAN 
Published: March 2017

ABSTRACTThe later Trecento repertoire contains many short, monostrophic ballatas with philosophical or moralising texts. Why should the poets and composers, mostly Florentine, have preferred the ballata over the madrigal when exploring serious subjects, and why did they employ the monostrophic form?It turns out that the text structure of the monostrophic ballata is, in its essentials, comparable to the pattern of the geometric demonstration from Euclid'sElements, comprising premise, argumentation and return to the enhanced, proved premise (quod erat demonstrandum). Considered in light of Florentine Humanism's engagement with philosophy, including Ockham methods of demonstration, this article examines the possibility that Francesco Landini and other composers were sufficiently influenced by philosophy to view the structure of the monostrophic ballata as a means of logical demonstrations of refined arguments.
The Event Chain of Survival in the Context of Music Festivals: A Framework for Improving Outcomes at Major Planned Events
Authors: Lund Adam , Turris Sheila 
Published: March 2017

AbstractDespite the best efforts of event producers and on-site medical teams, there are sometimes serious illnesses, life-threatening injuries, and fatalities related to music festival attendance. Producers, clinicians, and researchers are actively seeking ways to reduce the mortality and morbidity associated with these events. After analyzing the available literature on music festival health and safety, several major themes emerged. Principally, stakeholder groups planning in isolation from one another (ie, in silos) create fragmentation, gaps, and overlap in plans for major planned events (MPEs).The authors hypothesized that one approach to minimizing this fragmentation may be to create a framework to “connect the dots,” or join together the many silos of professionals responsible for safety, security, health, and emergency planning at MPEs. Adapted from the well-established literature regarding the management of cardiac arrests, both in and out of hospital, the “chain of survival” concept is applied to the disparate groups providing services that support event safety in the context of music festivals. The authors propose this framework for describing, understanding, coordinating and planning around the integration of safety, security, health, and emergency service for events. The adapted Event Chain of Survival contains six interdependent links, including: (1) event producers; (2) police and security; (3) festival health; (4) on-site medical services; (5) ambulance services; and (6) off-site medical services.The authors argue that adapting and applying this framework in the context of MPEs in general, and music festivals specifically, has the potential to break down the current disconnected approach to event safety, security, health, and emergency planning. It offers a means of shifting the focus from a purely reactive stance to a more proactive, collaborative, and integrated approach. Improving health outcomes for music festival attendees, reducing gaps in planning, promoting consistency, and improving efficiency by reducing duplication of services will ultimately require coordination and collaboration from the beginning of event production to post-event reporting.LundA, TurrisSA. The Event Chain of Survival in the context of music festivals: a framework for improving outcomes at major planned events. Prehosp Disaster Med. 2017;32(4):437–443.
Cross-sectional analysis of eating patterns and snacking in the US Feeding Infants and Toddlers Study 2008
Authors: Deming Denise M , Reidy Kathleen C , Fox Mary Kay , Briefel Ronette R , Jacquier Emma , Eldridge Alison L 
Published: March 2017

AbstractObjectiveTo explore eating patterns and snacking among US infants, toddlers and pre-school children.DesignThe Feeding Infants and Toddlers Study (FITS) 2008 was a cross-sectional national survey of children aged 6–47 months, weighted to reflect US age and racial/ethnic distributions. Dietary data were collected using one multiple-pass 24h recall. Eating occasions were categorized as meals, snacks or other (comprised of all feedings of breast milk and/or infant formula). The percentage of children consuming meals and snacks and their contribution to total energy, the number of snacks consumed per day, energy and nutrients coming from snacks and the most commonly consumed snacks were evaluated by age.SettingA national sample of US infants, toddlers and pre-school children.SubjectsA total of 2891 children in five age groups: 6–8 months (n 249), 9–11 months (n 256), 12–23 months (n 925), 24–35 months (n 736) and 36–47 months (n 725).ResultsSnacks were already consumed by 37 % of infants beginning at 6 months; by 12 months of age, nearly 95 % were consuming at least one snack per day. Snacks provided 25 % of daily energy from the age of 12 months. Approximately 40 % of toddlers and pre-school children consumed fruit and cow’s milk during snacks; about 25 % consumed 100 % fruit juice. Cookies were introduced early; by 24 months, 57 % consumed cookies or candy in a given day.ConclusionsSnacking is common, contributing significantly to daily energy and nutrient needs of toddlers and pre-school children. There is room for improvement, however, with many popular snacking choices contributing to excess sugar.
Interfaces in Oxides Formed on NiAlCr Doped with Y, Hf, Ti, and B
Authors: Boll Torben , Unocic Kinga A. , Pint Bruce A. , Stiller Krystyna 
Published: March 2017

AbstractThis study applies atom probe tomography (APT) to analyze the oxide scales formed on model NiAlCr alloys doped with Hf, Y, Ti, and B. Due to its ability to measure small amounts of alloying elements in the oxide matrix and its ability to quantify segregation, the technique offers a possibility for detailed studies of the dopant’s fate during high-temperature oxidation. Three model NiAlCr alloys with different additions of Hf, Y, Ti, and B were prepared and oxidized in O2 at 1,100°C for 100 h. All specimens showed an outer region consisting of different spinel oxides with relatively small grains and the protective Al2O3-oxide layer below. APT analyses focused mainly on this protective oxide layer. In all the investigated samples segregation of both Hf and Y to the oxide grain boundaries was observed and quantified. Neither B nor Ti were observed in the alumina grains or at the analyzed interfaces. The processes of formation of oxide scales and segregation of the alloying elements are discussed. The experimental challenges of the oxide analyses by APT are also addressed.
DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression
Authors: Barr Alexis R. , Cooper Samuel , Heldt Frank S. , Butera Francesca , Stoy Henriette , Mansfeld Jörg , Novák Béla , Bakal Chris 
Published: March 2017

AbstractFollowing DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic stability in the absence of exogenous DNA-damaging agents is unclear. Here, using live single-cell measurements of p21 protein in proliferating cultures, we show that naturally occurring DNA damage incurred over S-phase causes p53-dependent accumulation of p21 during mother G2- and daughter G1-phases. High p21 levels mediate G1 arrest via CDK inhibition, yet lower levels have no impact on G1 progression, and the ubiquitin ligases CRL4Cdt2 and SCFSkp2 couple to degrade p21 prior to the G1/S transition. Mathematical modelling reveals that a bistable switch, created by CRL4Cdt2, promotes irreversible S-phase entry by keeping p21 levels low, preventing premature S-phase exit upon DNA damage. Thus, we characterize how p21 regulates the proliferation-quiescence decision to maintain genomic stability.
Winter temperatures limit population growth rate of a migratory songbird
Authors: Woodworth Bradley K. , Wheelwright Nathaniel T. , Newman Amy E. , Schaub Michael , Norris D. Ryan 
Published: March 2017

AbstractUnderstanding the factors that limit and regulate wildlife populations requires insight into demographic and environmental processes acting throughout the annual cycle. Here, we combine multi-year tracking data of individual birds with a 26-year demographic study of a migratory songbird to evaluate the relative effects of density and weather at the breeding and wintering grounds on population growth rate. Our results reveal clear support for opposing forces of winter temperature and breeding density driving population dynamics. Above-average temperatures at the wintering grounds lead to higher population growth, primarily through their strong positive effects on survival. However, population growth is regulated over the long term by strong negative effects of breeding density on both fecundity and adult male survival. Such knowledge of how year-round factors influence population growth, and the demographic mechanisms through which they act, will vastly improve our ability to predict species responses to environmental change and develop effective conservation strategies for migratory animals.
Link of dietary patterns with metabolic syndrome: analysis of the National Health and Nutrition Examination Survey
Authors: Mazidi M , Pennathur S , Afshinnia F 
Published: March 2017

Abstract
Background:
Population-based interventions aimed at halting the increasing prevalence of metabolic syndrome (MetS) require thorough understanding of dietary interplays. Objective is to identify the independent dietary nutrients associated with MetS and its components using dietary pattern identification and the single-nutrient approaches in The United States.

Methods:
This is a cross-sectional observation. Participants are selected from the National Health and Nutrition Examination Survey (NHANES) with available dietary intake, biochemical and anthropometrical data from 2001 to 2012. Exposure is diet obtained from 24-h dietary recall. Main outcome measure is MetS and its components.

Results:
Overall, 23 157 eligible individuals including 6561 with MetS were included in the final analysis. Using principle component analysis, we identified three food patterns that explained 50.8% of the variance of the dietary nutrient consumption. The highest quartile of the factor score representative of saturated/monounsaturated fatty acids or the first dietary pattern was associated with 1.27-fold (95% confidence interval (CI): 1.10–1.46, P=0.001) higher odds of association with MetS when compared with the first quartile. The second pattern representative of vitamins and trace elements had an odds ratio of 0.79 (95% CI: 0.70–0.89, P<0.001) for association with MetS, and the third pattern representative of polyunsaturated fatty acids did not have any association with MetS. The nutrient-by-nutrient approach showed that mild alcohol intake and lower consumption of total saturated fatty acids and sodium were associated with lower risk of MetS.

Conclusions:
Application of multiple complementary analytic approaches reveals more comprehensive dietary determinants of MetS and its components as potential intervening targets.
Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway
Authors: Vasconcelos-dos-Santos A , Loponte H F B R , Mantuano N R , Oliveira I A , de Paula I F , Teixeira L K , de-Freitas-Junior J C M , Gondim K C , Heise N , Mohana-Borges R , Morgado-Díaz J A , Dias W B , Todeschini A R 
Published: March 2017

AbstractHyperglycemia is a common feature of diabetes mellitus, considered as a risk factor for cancer. However, its direct effects in cancer cell behavior are relatively unexplored. Herein we show that high glucose concentration induces aberrant glycosylation, increased cell proliferation, invasion and tumor progression of colon cancer. By modulating the activity of the rate-limiting enzyme, glutamine-fructose-6-phosphate amidotransferase (GFAT), we demonstrate that hexosamine biosynthetic pathway (HBP) is involved in those processes. Biopsies from patients with colon carcinoma show increased levels of GFAT and consequently aberrant glycans’ expression suggesting an increase of HBP flow in human colon cancer. All together, our results open the possibility that HBP links hyperglycemia, aberrant glycosylation and tumor malignancy, and suggest this pathway as a potential therapeutic target for colorectal cancer.
Therapeutic efficacy of neural stem cells originating from umbilical cord-derived mesenchymal stem cells in diabetic retinopathy
Authors: Zhang Wei , Wang Yuexin , Kong Jiahui , Dong Meng , Duan Hongtao , Chen Song 
Published: March 2017

AbstractThe aim of this study was to evaluate the effects of intravitreal injection of neural stem cells (NSCs) originating from human umbilical cord-derived mesenchymal stem cells (UC-MSCs) on neurodegeneration of diabetic retinopathy (DR) in rats. UC-MSCs were isolated and passaged, followed by induction to NSCs in neural differentiation medium. Four weeks following NSC transplantation, treatment attenuated retinal vascular dysfunction compared with non-treated rats, and BDNF and Thy-1 expression was significantly higher in the treated group than in the control group. Treatment of diabetic rats with NSCs prevented the decrease in BDNF levels caused by diabetes. The average leakage of Evans Blue (EB) dye in the treated group was significantly less than that in the control group. These morphological improvements were accompanied by a restoration of vision, as documented by F-ERG. NSCs originating from MSCs demonstrated a neuroprotective effect by increasing the number of surviving RGCs and significantly reducing the progression of DR. Thus, transplantation of NSCs could be a novel strategy for the treatment of neurodegeneration in DR.
Quantitative profiling of glycerophospholipids during mouse and human macrophage differentiation using targeted mass spectrometry
Authors: Zhang Cuiping , Wang Yi , Wang Fang , Wang Zhenxin , Lu Yu , Xu Ying , Wang Ke , Shen Huali , Yang Pengyuan , Li Shan , Qin Xue , Yu Hongxiu 
Published: March 2017

AbstractMacrophage lipid metabolism plays a pivotal role in innate and adaptive immune responses. Previous studies have shown that this process plays a role in infections and contributes to the pathogenesis of diabetes, atherosclerosis, and other immunometabolic diseases. M1 macrophages, or classically activated macrophages, are key players in the defense against bacterial infections. M2 macrophages, or alternatively activated macrophages, are involved in anti-inflammatory responses. Using the multiple reaction monitoring method, we identified changes in lipid composition during the differentiation of human and murine macrophages. We detected over 300 lipid molecules in mammalian macrophages, and we observed a striking shift in the composition of glycerophospholipids (GLs) from saturated and monounsaturated to polyunsaturated during human macrophage polarization. Moreover, M2 macrophages showed a higher level of lysophospholipids (lysoGLs) than did M1 macrophages. The lysoPI species increased in human and mouse M2 macrophages, suggesting that they may be involved in M2 macrophage polarization and anti-inflammatory processes. Collectively, these results indicate that lipids may play a role in the pro- and anti-inflammatory activities of macrophages and may be markers of the macrophage activation state.
The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects
Authors: Matsuura Masato , Murata Hiroshi , Nakakura Shunsuke , Nakao Yoshitaka , Yamashita Takehiro , Hirasawa Kazunori , Fujino Yuri , Kiuchi Yoshiaki , Asaoka Ryo 
Published: March 2017

AbstractWe previously reported that a shallow circumpapillary retinal nerve fiber layer (cpRNFL) peak angle as measured by optical coherence tomography (OCT) suggests the temporal retina is stretched around the optic disc from the papillo-macular bundle (Yamashita T et al. Investigative Ophthalmol Vis Sci 2013). The purpose of the current study was to investigate the relationship between CorvisST tonometry (CST) corneal measurements, axial length (AL) and the change in OCT-measured cpRNFL peak angle, in young healthy subjects. OCT and CST measurements were carried out in 97 eyes of 97 young healthy volunteers. The relationship between cpRNFL peak angle and 12 CST parameters, adjusted for AL, was investigated using linear modelling. The mean ± standard deviation cpRNFL peak angle of the 97 healthy volunteers was 130.6 ± 25.4 (range: 77.8 to 207.0) degrees. The optimal linear model to explain cpRNFL peak angle (chosen from 216 different models) included three CST variables related to the speed and size of energy absorption (namely, A1 time, A1 length and A2 time), in addition to AL. In eyes with longer AL and shorter energy absorption in CST measurement, temporal retina is stretched around the optic disc from the papillo-macular bundle, as suggested by a shallow cpRNFL peak angle.
Occlusion and Disocclusion Time Changes in Single Unit Crowns Designed by Functional Generated Path Technique: A Randomised Clinical Trial
Authors: Lin Ping-ting , Jiao Yang , Zhao San-jun , Wang Fu , Li Ling , Yu Fan , Tian Min , Yu Hao-han , Chen Ji-hua 
Published: March 2017

AbstractAlthough it is believed that implementation of the functional generated path (FGP) technique can facilitate occlusal surface design for restorations, it has not been objectively compared in situ with the conventional fabrication yet. Therefore, in the present study, a single-blind crossover clinical trial was conducted using T-scan to compare changes in occlusion time (OT) and disocclusion time (DT) of single posterior artificial crowns designed differently using FGP technique (FGP), average-value FGP technique (AVR) and conventional fabrication (CON). Each of the 10 participants took part in the study tried three artificial crowns in different sequences according to a computer generated randomization list. The results objectively revealed that changes in OT and DT were significantly smaller for FGP than CON (P < 0.05) and considerably smaller for AVR than CON, respectively. The subjective feedback and the occlusal adjusting time were better and shorter for FGP and AVR than CON (P < 0.05). No harm to the participants occurred. Overall, FGP is an efficient technique showing more physiological harmonious relationship with the articulating system.