bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbidities in Patients With Primary Sjögren's Syndrome and Systemic Lupus Erythematosus: A Comparative Registries‐Based Study
Authors: Rúa‐Figueroa Iñigo , Fernández Castro Mónica , Andreu José L. , Sanchez‐Piedra Carlos , Martínez‐Taboada Víctor , Olivé Alejandro , López‐Longo Javier , Rosas José , Galindo María , Calvo‐Alén Jaime , Fernández‐Nebro Antonio , Alonso Fernando , Rodríguez‐Lozano Beatriz , Alberto García Vadillo Jesús , Menor Raúl , Narváez Francisco Javier , Erausquin Celia , García‐Aparicio Ángel , Tomero Eva , Manrique‐Arija Sara , Horcada Loreto , Uriarte Esther , Gil Susana , Blanco Ricardo , López‐González Ruth , Boteanu Alina , Freire Mercedes , Galisteo Carlos , Rodríguez‐Gómez Manuel , Díez‐Álvarez Elvira , Pego‐Reigosa José M. ,   on behalf of Sjogrenser and Relesser Researchers and EAS‐SER Group
Published: August 2016

ObjectiveTo compare the prevalence of the main comorbidities in 2 large cohorts of patients with primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), with a focus on cardiovascular (CV) diseases.MethodsThis was a cross‐sectional multicenter study where the prevalence of more relevant comorbidities in 2 cohorts was compared. Patients under followup from SJOGRENSER (Spanish Rheumatology Society Registry of Primary SS) and RELESSER (Spanish Rheumatology Society Registry of SLE), and who fulfilled the 2002 American–European Consensus Group and 1997 American College of Rheumatology classification criteria, respectively, were included. A binomial logistic regression analysis was carried out to explore potential differences, making general adjustments for age, sex, and disease duration and specific adjustments for each variable, including CV risk factors and treatments, when appropriate.ResultsA total of 437 primary SS patients (95% female) and 2,926 SLE patients (89% female) were included. The mean age was 58.6 years (interquartile range [IQR] 50.0–69.9 years) for primary SS patients and 45.1 years (IQR 36.4–56.3 years) for SLE patients (P < 0.001), and disease duration was 10.4 years (IQR 6.0–16.7 years) and 13.0 years (IQR 7.45–19.76 years), respectively (P < 0.001). Smoking, dyslipidemia, and arterial hypertension were associated less frequently with primary SS (odds ratio [OR] 0.36 [95% confidence interval (95% CI) 0.28–0.48], 0.74 [95% CI 0.58–0.94], and 0.50 [95% CI 0.38–0.66], respectively) as were life‐threatening CV events (i.e., stroke or myocardial infarction; OR 0.57 [95% CI 0.35–0.92]). Conversely, lymphoma was associated more frequently with primary SS (OR 4.41 [95% CI 1.35–14.43]). The prevalence of severe infection was lower in primary SS than in SLE (10.1% versus 16.9%; OR 0.54 [95% CI 0.39–0.76]; P < 0.001).ConclusionPrimary SS patients have a consistently less serious CV comorbidity burden and a lower prevalence of severe infection than those with SLE. In contrast, their risk of lymphoma is greater.
Factors Associated With Sustained Remission in Rheumatoid Arthritis in Patients Treated With Anti–Tumor Necrosis Factor
Authors: Hamann Philip , Holland Richard , Hyrich Kimme , Pauling John D. , Shaddick Gavin , Nightingale Alison , McHugh Neil 
Published: August 2016

ObjectiveAnti–tumor necrosis factor (anti‐TNF) antibody has revolutionized the treatment of rheumatoid arthritis (RA), and remission is now a realistic possibility for patients. Despite widespread use of anti‐TNFs, predicting which patients are most likely to attain a sustained good response to these treatments remains challenging. Our objective was to undertake a systematic review of the literature to evaluate existing evidence for demographic and clinical factors associated with the achievement of sustained remission in individuals with RA treated with anti‐TNF therapy.MethodsEmbase, Medline, and the Cochrane Controlled Trials Register were searched along with studies identified from reference lists. Quality of studies was assessed using Newcastle‐Ottawa criteria. Meta‐analysis was undertaken where unadjusted odds ratios were available for the same demographic or clinical factors from at least 3 studies.ResultsSix studies were identified. Concomitant methotrexate use was associated with an increased likelihood of achieving sustained remission. Greater baseline disease activity, tender joint count, age, disease duration, baseline functional impairment, and female sex were associated with reduced likelihood of achieving sustained remission.ConclusionFactors predicting sustained remission are seldom reported. Evidence identified in this review supports current recommendations for methotrexate coprescription and highlights the negative impact of particular clinical and demographic features on the likelihood of achieving optimal response to anti‐TNF treatment. Sustained remission is clinically more relevant than point remission in RA. More widespread reporting of sustained remission will help clinicians set realistic expectations on likely long‐term treatment efficacy and could be an important tool for identifying patients suitable for dose optimization.
Infant lower extremity long bone growth rates: comparison of contemporary with early 20th century data using mixed effect models
Authors: Tsai Andy , Stamoulis Catherine , Barber Ignasi , Kleinman Paul K. 
Published: August 2016

AbstractObjectivesModern reference standards for long bone growth are lacking for infants (≤1 year). This study develops a quantitative framework to characterize lower extremity bone shaft growth during infancy based on radiographic images, and compares it to data from the 1930s.MethodsFemoral, tibial, and fibular shaft length measurements (diaphysis plus metaphysis) were collected retrospectively from 70 infants on initial and follow‐up skeletal surveys performed for suspected abuse (7/2005—2/2013). These serial skeletal survey data (SSSD) were compared to the Denver Child Research Council data (DCRCD), a 1930's longitudinal dataset from 80 infants. Mixed effects regression models were developed to estimate growth trajectories from these data. Growth trajectories and short‐term (≤2 months) growth rates were compared.ResultsStatistically distinct models described the contemporary (SSSD) and historic (DCRCD) datasets; however, there was substantial overlap (77—90%) between their confidence bands for the three measured bones. Based on developed models, the average long bone shafts of the DCRCD are shorter at birth than SSSD (femur: 77.0 vs. 82.3 mm; tibia: 64.4 vs. 68.2 mm; fibula: 61.0 vs. 64.4 mm), but the DCRCD long bone growth rates are faster than SSSD (femur: 0.21 vs. 0.17 mm/day; tibia: 0.16 vs. 0.14 mm/day; fibula: 0.15 vs. 0.14 mm/day). Short‐term growth rates of these bones decreased with age. The effect of sexual dimorphism on long bone growth during infancy was non‐significant.ConclusionThis study provides reference standards for long bone growth rates during the dynamic period of infancy that may aid clinical assessment, and also inform research studies of disorders associated with altered skeletal growth.
The Association of Vibratory Perception and Muscle Strength With the Incidence and Worsening of Knee Instability: The Multicenter Osteoarthritis Study
Authors: Shakoor Najia , Felson David T. , Niu Jingbo , Nguyen Uyen‐Sa , Segal Neil A. , Singh Jasvinder A. , Nevitt Michael C. 
Published: August 2016

ObjectiveTo examine neuromuscular factors that predict the incidence and progression of knee instability symptoms in older adults with or at high risk of knee osteoarthritis (OA).MethodsAt the 60‐month clinic visit, participants in the Multicenter Osteoarthritis Study underwent evaluation of quantitative vibratory sense at the knee and isokinetic quadriceps muscle strength. At this 60‐month visit, participants were also asked about knee buckling and sensations of knee shifting or slipping without buckling in the past 3 months and then were asked the same questions at the 72‐ and 84‐month follow‐up visits. We performed a person‐based analysis using Poisson regression analysis with robust error variance to estimate adjusted relative risks (RRs) for the association of vibratory sense and muscle strength with the incidence and worsening of knee slipping/shifting, buckling, and overall knee instability symptoms (either buckling or knee shifting/slipping), with adjustment for relevant confounders.ResultsA total of 1,803 participants (61% women) were included. Approximately one‐third of the participants reported incident or worsening of instability symptoms over the study period. After adjustment for relevant confounders, better vibratory acuity (adjusted RR 0.78, 95% confidence interval [95% CI] 0.56–1.09), P = 0.020 for trend) and greater quadriceps strength (adjusted RR 0.53, 95% CI 0.38–0.75, P < 0.001) protected against incident knee instability symptoms. Greater quadriceps strength (adjusted RR 0.73, 95% CI 0.58–0.92, P = 0.008) also protected against worsening of knee instability symptoms.ConclusionVibratory acuity and quadriceps muscle strength are important predictors of the incidence and worsening of knee instability over 2 years. These neuromuscular factors are potentially modifiable and should be considered in interventional studies of instability in persons with or at risk of knee OA.
RANK‐Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis
Authors: O'Brien William , Fissel Brian M. , Maeda Yukiko , Yan Jing , Ge Xianpeng , Gravallese Ellen M. , Aliprantis Antonios O. , Charles Julia F. 
Published: August 2016

ObjectiveProinflammatory molecules promote osteoclast‐mediated bone erosion by up‐regulating local RANKL production. However, recent evidence suggests that combinations of cytokines, such as tumor necrosis factor (TNF) plus interleukin‐6 (IL‐6), induce RANKL‐independent osteoclastogenesis. The purpose of this study was to better understand TNF/IL‐6–induced osteoclast formation and to determine whether RANK is absolutely required for osteoclastogenesis and bone erosion in murine inflammatory arthritis.MethodsMyeloid precursors from wild‐type (WT) mice or mice with either germline or conditional deletion of Rank, Nfatc1, Dap12, or Fcrg were treated with either RANKL or TNF plus IL‐6. Osteoprotegerin, anti–IL‐6 receptor (anti–IL‐6R), and hydroxyurea were used to block RANKL, the IL‐6R, and cell proliferation, respectively. Clinical scoring, histologic assessment, micro–computed tomography, and quantitative polymerase chain reaction (qPCR) were used to evaluate K/BxN serum–transfer arthritis in WT and RANK‐deleted mice. Loss of Rank was verified by qPCR and by osteoclast cultures.ResultsTNF/IL‐6 generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL‐6R, NFATc1, DNAX‐activation protein 12, and cell proliferation, but independent of RANKL or RANK. Bone erosion and osteoclast formation were reduced, but not absent, in arthritic mice with inducible deficiency of RANK. TNF/IL‐6, but not RANKL, induced osteoclast formation in bone marrow and synovial cultures from animals deficient in Rank. Multiple IL‐6 family members (IL‐6, leukemia inhibitory factor, oncostatin M) were up‐regulated in the synovium of arthritic mice.ConclusionThe persistence of bone erosion and synovial osteoclasts in Rank‐deficient mice, and the ability of TNF/IL‐6 to induce osteoclastogenesis, suggest that more than one cytokine pathway exists to generate these bone‐resorbing cells in inflamed joints.
Effect of soil texture and hydraulic parameters on WRF simulations in summer in east China
Authors: He J. J. , Yu Y. , Yu L. J. , Yin C. M. , Liu N. , Zhao S. P. , Chen X. 
Published: August 2016

AbstractThis article investigated the effect of soil texture, i.e. 5‐min Food and Agriculture Organization soil texture (STFAO) and 30' Harmonized World Soil Database soil texture (STHWSD), and hydraulic parameters, i.e. US Department of Agriculture soil hydraulic parameters (SPUS) and China soil hydraulic parameters (SPCH), on the Weather Research and Forecasting (WRF) model simulation in summer in eastern China. Near‐surface meteorological fields from 365 automatic weather stations were used to evaluate the performance of WRF. Obvious differences between the two soil texture datasets and the two soil hydraulic parameter datasets were found. The simulated 2‐m temperature, 2‐m specific humidity, and 10‐m wind speed were improved significantly at a 95% confidence interval via bootstrap test when STHWSD was used. The agreement is weaker as SPUS was replaced by SPCH. Soil texture and hydraulic parameters affect surface energy partitioning and the distribution of precipitation. The influence of wilting point on WRF's performance is more significant than other soil hydraulic parameters.
Determination of antibacterial agent tilmicosin in pig plasma by LC/MS/MS and its application to pharmacokinetics
Authors: Li Bing , Gong Shi‐Yue , Zhou Xu‐Zheng , Yang Ya‐Jun , Li Jian‐Yong , Wei Xiao‐Juan , Cheng Fu‐Sheng , Niu Jian‐Rong , Liu Xi‐Wang , Zhang Ji‐Yu 
Published: August 2016

AbstractA rapid and sensitive high‐performance liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated to quantify tilmicosin in pig plasma. Plasma samples were prepared by liquid–liquid extraction. Chromatographic separation was achieved on a C18 column (2.1 × 30 mm, 3.5 μm) using acetonitrile–water (90:10, v/v; water included 0.1% formic acid) as the mobile phase. Mass detection was carried out using positive electrospray ionization in multiple reaction monitoring mode. The calibration curve was linear from 0.5 to 2000 ng/mL (r2 = 0.9998). The intra‐ and inter‐day accuracy and precision were within the acceptable limits of ±10% for all tilmicosin concentrations. The recoveries ranged from 95 to 99% for the three tested concentrations. The LC–MS/MS method described herein was simple, fast and less laborious than other methods, achieved high sensitivity using a small sample volume, and was successfully applied to pharmacokinetic studies of tilmicosin enteric granules after oral delivery to pigs. In comparison with tilmicosin premix, tilmicosin enteric granules slowed the elimination rate of tilmicosin, prolonged its period of action and significantly improved its bioavailability.
Bipolar irrigated radiofrequency ablation of resistant ventricular tachycardia with a septal intramural origin: the initial experience and a description of the method
Authors: Baszko Artur , Telec Wojciech , Kałmucki Piotr , Iwachów Piotr , Kochman Karol , Szymański Radosław , Kłopocki Jan , Ożegowski Stefan , Szyszka Andrzej , Siminiak Tomasz 
Published: August 2016

Key Clinical MessageBipolar radiofrequency (RF) ablation is effective in treatment of ventricular tachycardia originating from thick interventricular septum. The RF generator and CARTO system can be used to precisely and safely perform ablation. Standard ablation catheter can be used with indifferent ablation electrode connected to the electrode receptacle in RF generator with custom‐made cable.
Immature gastric teratoma in an infant: a case report and review of the literatures
Authors: Junhasavasdikul Thitiporn , Ruangwattanapaisarn Nichanan , Molagool Sani , Lertudomphonwanit Chatmanee , Sirachainan Nongnuch , Larbcharoensub Noppadol 
Published: August 2016

Key Clinical MessageImmature gastric teratoma is an uncommon germ cell tumor of the stomach. We report a rare case of immature gastric teratoma in an infant with down syndrome with clinically presenting with hematemesis and severe anemia. Complete surgical resection remains the cornerstone of treatment.
Substrate‐Assisted Deposition of Metal Oxides on Three‐Dimensional Porous Reduced Graphene Oxide Networks as Bifunctional Hybrid Electrocatalysts for the Oxygen Evolution and Oxygen Reduction Reactions
Authors: Zhao Mengjia , Li Xiaoxue , Song Long , He Di , Zhang Zhipan 
Published: August 2016

AbstractThe oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) are of great importance for energy conversion processes, such as water electrolysis, metal–air batteries, and fuel cells. Herein, we report a substrate‐assisted in situ reduction method to prepare three‐dimensional reduced graphene oxide (3DRGO) networks decorated with a range of mixed cobalt oxide and nickel oxide nanosheets as a new type of bifunctional catalyst for oxygen evolution and oxygen reduction. Among the different composite catalysts, Co3O4@3DRGO showed highest catalytic activities in OER and ORR with an excellent stability. This catalyst is used to catalyze the oxygen reactions in a Zn–air battery as a proof‐of‐concept. The current results render new insights into developing low‐cost, next‐generation bifunctional catalysts for photoelectrochemical cells for energy storage and conversion.
Nanocasting Design and Spatially Selective Sulfonation of Polystyrene‐Based Polymer Networks as Solid Acid Catalysts
Authors: Richter Felix H. , Sahraoui Laila , Schüth Ferdi 
Published: August 2016

AbstractNanocasting is a general and widely applied method in the generation of porous materials during which a sacrificial solid template is used as a mold on the nanoscale. Ideally, the resulting structure is the inverse of the template. However, replication is not always as direct as anticipated, so the influences of the degree of pore filling and of potential restructuring processes after removal of the template need to be considered. These apparent limitations give rise to opportunities in the synthesis of poly(styrene‐co‐divinylbenzene) (PSD) polymer networks of widely varying porosities (BET surface area=63–562 m2 g−1; Vtot=0.18–1.05 cm3 g−1) by applying a single synthesis methodology. In addition, spatially selective sulfonation on the nanoscale seems possible. Together, nanocasting and sulfonation enable rational catalyst design. The highly porous nanocast and predominantly surface‐sulfonated PSD networks approach the activity of the corresponding molecular catalyst, para‐toluenesulfonic acid, and exceed those of commercial ion‐exchange polymers in the depolymerization of macromolecular inulin.
Multimode non‐Gaussian process monitoring based on local entropy independent component analysis
Authors: Zhong Na , Deng Xiaogang 
Published: August 2016

AbstractTraditionally, independent component analysis (ICA) as a multivariate statistical process monitoring (MSPM) method has attracted considerable attention due to its excellent ability in analysis of non‐Gaussian datasets. However, it may degrade fault detection performance for multimode operating process because of its assumption of one single steady mode. In order to supervise the non‐Gaussian process with multiple steady modes more effectively, this paper proposes a process monitoring method based on local entropy independent component analysis (LEICA). This method applies local probability density estimation to remove the effects of multimode characteristics. Furthermore, information entropy theory is used to extract the feature information of process data by calculating their local information entropies. Based on these local entropy data, ICA is applied to establish the local entropy component model for fault detection. Lastly, a numerical example and the Tennessee Eastman (TE) process are used to verify the proposed method and the results demonstrate the superiority of LEICA method.
Continuous hydrogen production by dark fermentation in a foam SiC ceramic packed up‐flow anaerobic sludge blanket reactor
Authors: Sui Hong , Dong Jiao , Wu Mengjia , Li Xingang , Zhang Ruiling , Wu Guozhong 
Published: August 2016

AbstractBiohydrogen generation using anaerobic sludge from a sewage treatment plant is a promising strategy for converting waste into renewable energy. The porous foam SiC ceramic structured packing was used as a support in the up‐flow anaerobic sludge blanket (UASB) reactor to enhance the biohydrogen yield. Using glucose as the major carbon source, the SiC‐UASB reactor was continuously operated under the organic loading rates (OLR) between 30 and 90 gglucose/L · d at a hydraulic retention time (HRT) of 4 h. The maximum hydrogen production rate (5.24 L/L · d) and hydrogen content (50 %) were obtained at 60 gglucose/L · d OLR. It demonstrated that the reaction of fermentation was predominated by the butyric acid pathway. The employment of SiC packings resulted in quick startup (∼5 days) and high efficiency of hydrogen production. The buffering capacity and the cell culture immobilization ability of the UASB reactor were obviously improved by the application of SiC packings, which increased the feasibility of scale‐up of the continuous biohydrogen production system.
A quantitative survey of GRAPPA reconstruction in parallel MRI: impact on noise reduction and aliasing
Authors: Madhusoodhanan Sreekanth , Paul Joseph Suresh 
Published: August 2016

AbstractIn recent years, several attempts have been made to improve the quality of GRAPPA reconstruction by concomitant reduction of noise amplification and aliasing. While it is true that accuracy of the underlying GRAPPA model depends on the goodness of fit, variations in input noise and channel encoding can serve to introduce differences in reconstruction. In this article, we quantitatively compare the performance of different GRAPPA types, in relation to input signal‐to‐noise ratio, channel number, and acceleration factor. The GRAPPA types considered in this article are obtained using: (1) calibration matrix modification, (2) regularization of calibration equation, (3) updating of coil coefficients, (4) intermediate domain GRAPPA, and (5) iterative method. All the above GRAPPA types are tested on retrospectively sampled in vivo datasets acquired using head, spine and knee‐array coils. For each GRAPPA type and dataset analyzed, reconstruction is performed using number of Autocalibration Signal lines set at 10% of the number of phase‐encodes used in full acquisition and kernel size optimized for minimum root‐mean square‐error (RMSE). Each GRAPPA type is rated based on their individual performance, in relation to a mean performance measure obtained by averaging across different methods. Noise amplification in each GRAPPA type is visually examined, and compared with the respective g‐factor map. RMSEs and g‐factors of in vivo data are compared against those of simulated coil images with added complex Gaussian noise having a pre‐determined covariance structure. A summary of performance ratings and execution times are provided for comparison with standard GRAPPA.
Fluorescence Dynamics in the Endoplasmic Reticulum of a Live Cell: Time‐Resolved Confocal Microscopy
Authors: Ghosh Shirsendu , Nandi Somen , Ghosh Catherine , Bhattacharyya Kankan 
Published: August 2016

AbstractThe front cover artwork is provided by the group of Prof. Kankan Bhattacharyya. The image shows calcium ion binding/unbinding in the endoplasmic reticulum (ER) region involved complex structural reorganizations. The consequent fluctuations in local environment cause fluorescence intensity oscillations of ER‐tracker dye. Read the full text of the article at 10.1002/cphc.201600425.