bluuebunny/crossref_metadata_2025_split huggingface dataset:
The simplicity principle in perception and cognition
Authors: Feldman Jacob 
Published: August 2016

The simplicity principle, traditionally referred to as Occam's razor, is the idea that simpler explanations of observations should be preferred to more complex ones. In recent decades the principle has been clarified via the incorporation of modern notions of computation and probability, allowing a more precise understanding of how exactly complexity minimization facilitates inference. The simplicity principle has found many applications in modern cognitive science, in contexts as diverse as perception, categorization, reasoning, and neuroscience. In all these areas, the common idea is that the mind seeks the simplest available interpretation of observations— or, more precisely, that it balances a bias toward simplicity with a somewhat opposed constraint to choose models consistent with perceptual or cognitive observations. This brief tutorial surveys some of the uses of the simplicity principle across cognitive science, emphasizing how complexity minimization in a number of forms has been incorporated into probabilistic models of inference. WIREs Cogn Sci 2016, 7:330–340. doi: 10.1002/wcs.1406This article is categorized under:

Philosophy > Foundations of Cognitive Science
Prediction of local wind climatology from Met Office models: Virtual Met Mast techniques
Authors: Standen Jessica , Wilson Clive , Vosper Simon , Clark Peter 
Published: August 2016

AbstractThe Met Office has developed the Virtual Met Mast™ (VMM) tool for assessing the feasibility of potential wind farm sites. It provides site‐specific climatological wind information for both onshore and offshore locations. The VMM relies on existing data from past forecasts from regional‐scale numerical weather prediction (NWP) models, to which corrections are applied to account for local site complexity. The techniques include corrections to account for the enhanced roughness lengths used in NWP models to represent drag due to sub‐grid orography and downscaling methods that predict local wind acceleration over small‐scale terrain. The corrected NWP data are extended to cover long periods (decades) using a technique in which the data are related to alternative long‐term datasets. For locations in the UK, the VMM currently relies on operational mesoscale model forecast data at 4 km horizontal resolution. Predictions have been verified against observations made at typical wind turbine hub heights at over 80 sites across the UK. In general, the predictions compare well with the observations. The techniques provide an efficient method for screening potential wind resource sites. Examples of how the VMM techniques can be used to produce local wind maps are also presented. © 2016 Crown copyright. Wind Energy © 2016 John Wiley & Sons, Ltd
Gifted microbes for genome mining and natural product discovery
Authors: Baltz Richard H 
Published: August 2016

AbstractActinomycetes are historically important sources for secondary metabolites (SMs) with applications in human medicine, animal health, and plant crop protection. It is now clear that actinomycetes and other microorganisms with large genomes have the capacity to produce many more SMs than was anticipated from standard fermentation studies. Indeed ~90 % of SM gene clusters (SMGCs) predicted from genome sequencing are cryptic under conventional fermentation and analytical analyses. Previous studies have suggested that among the actinomycetes with large genomes, some have the coding capacity to produce many more SMs than others, and that strains with the largest genomes tend to be the most gifted. These contentions have been evaluated more quantitatively by antiSMASH 3.0 analyses of microbial genomes, and the results indicate that many actinomycetes with large genomes are gifted for SM production, encoding 20–50 SMGCs, and devoting 0.8–3.0 Mb of coding capacity to SM production. Several Proteobacteria and Firmacutes with large genomes encode 20–30 SMGCs and devote 0.8–1.3 Mb of DNA to SM production, whereas cultured bacteria and archaea with small genomes devote insignificant coding capacity to SM production. Fully sequenced genomes of uncultured bacteria and archaea have small genomes nearly devoid of SMGCs.
mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism
Authors: Vogel Kara R. , Ainslie Garrett R. , Gibson K. Michael 
Published: August 2016

AbstractRecent studies have identified a role for supraphysiological gamma‐aminobutyric acid (GABA) in the regulation of mechanistic target of rapamycin (mTOR), a protein kinase with pleiotropic roles in cellular development and homeostasis, including integration of growth factors and nutrient sensing and synaptic input in neurons (Lakhani et al. 2014; Vogel et al. 2015). Aldehyde dehydrogenase 5a1‐deficient (aldh5a1‐/‐) mice, the murine orthologue of human succinic semialdehyde dehydrogenase deficiency (SSADHD), manifest increased GABA that disrupts mitophagy and increases mitochondria number with enhanced oxidant stress. Treatment with the mTOR inhibitor, rapamycin, significantly attenuates these GABA‐related anomalies. We extend those studies through characterization of additional rapamycin analog (rapalog) agents including temsirolimus, dual mTOR inhibitors [Torin 1 and 2 (Tor 1/ Tor 2), Ku‐0063794, and XL‐765], as well as mTOR‐independent autophagy inducers [trehalose, tat‐Beclin 1, tacrolimus (FK‐506), and NF‐449) in aldh5a1‐/‐ mice. Rapamycin, Tor 1, and Tor 2 rescued these mice from premature lethality associated with status epilepticus. XL‐765 extended lifespan significantly and induced weight gain in aldh5a1‐/‐ mice; untreated aldh5a1‐/‐ mice failed to increase body mass. Expression profiling of animals rescued with Tor 1/Tor 2 and XL‐765 revealed multiple instances of pharmacological compensation and/or correction of GABAergic and glutamatergic receptors, GABA/glutamate transporters, and GABA/glutamate‐associated proteins, with Tor 2 and XL‐765 showing optimal outcomes. Our studies lay the groundwork for further evaluation of mTOR inhibitors in aldh5a1‐/‐ mice, with therapeutic ramifications for heritable disorders of GABA and glutamate neurotransmission.
Analytical differentiation of quinolinyl- and isoquinolinyl-substituted 1-(5-fluoropentyl)-1H-indole-3-carboxylates: 5F-PB-22 and its ten isomers
Authors: Kohyama Erina , Chikumoto Takao , Tada Hiroyuki , Kitaichi Kiyoyuki , Ito Tetsuro 
Published: August 2016

Abstract
Differentiation among regioisomers of synthetic cannabinoids in forensic drug analysis is a crucial issue, since all isomers are not regulated by law. New equivalent analogs obtained via minor modification of their preexisting molecules keep on emerging. Isomers formed via substitutional exchange are also a cause for concern. This study is focused on the isomeric molecules that stem from minor modifications of 5F-PB-22. The analytical properties of these molecules and methods of differentiation are reported. Scan mode analysis using gas chromatography–electron ionization-mass spectrometry (GC–EI-MS) was performed using the authentic 5F-PB-22 standard, five regioisomeric quinolinyl ester indoles, and five regioisomeric isoquinolinyl ester indoles. Because it was not possible to separate 5F-PB-22 from the 5-hydroxyquinoline isomer using GC and all analytes showed similar EI mass spectra, liquid chromatography (LC)–tandem mass spectrometry analysis was performed. Using LC, a successful separation of 5F-PB-22 from all isomers could be achieved. Based on the electrospray ionization-mass spectra, the protonated molecular ion at m/z 377.2 was selected as the precursor ion for the regioisomeric and structural isomeric differentiation. Collision-induced dissociation provides relative intensity differences in the product ions among the isomers, enabling mass spectrometric differentiation of the isomers. To our knowledge, this is the first report on mass spectrometric differentiation of 5F-PB-22 and its ten isomers.
Spica magnetic resonance imaging for determination of abduction angle: Initial results and reproducibility assessment
Authors: Rivlin M. J. , Kan J. H. , Schallert E. K. , Jadhav S. P. , Zhang W. , Rosenfeld S. B. 
Published: August 2016

Purpose Spica magnectic resonance imaging (MRI) is an established technique for postoperative determination of hip reduction in patients treated for developmental dysplasia of the hip (DDH). A hip abduction angle >55° is considered excessive and has been associated with epiphyseal osteonecrosis. Our purpose was to establish objective criteria for measuring hip abduction angles on MRI after hip reduction and spica casting in patients with DDH, and evaluate reproducibility and reliability of angle measurement using these criteria. Methods Forty patients with DDH at our institution who underwent spica MRI after hip reduction between 3 April 2008 and 3 March 2015 were identified. Hip abduction angles were measured on proton density axial images as follows. A transverse line was drawn connecting the posterior ischial tuberosities. A second line was drawn medially along the distal femoral diaphysis, and the angle between these two lines was measured; this value was subtracted from 90°, yielding the degree of abduction from midline. Measurements were independently performed by three faculty radiologists, one orthopedist, and one radiology resident. Inter-reader and intra-reader reliability was assessed using intraclass correlation (ICC), with 0 representing no agreement and 1 representing perfect agreement. Results For inter-reader reliability, the ICC of the five physicians was 0.89 (95 % CI 0.84–0.92). For intra-reader reliability, the ICC of the five physicians ranged from 0.90−0.97 (95 % CI 0.85–0.98). The mean standard deviation of hip abduction angle measurement among readers was 3.6°. Conclusion The proposed hip abduction angle measurement criteria for spica MRI are both reproducible and easy to perform. The high ICC and low standard deviation of independently evaluated hip abduction angles indicates high reproducibility of measurement. This applies to both inter- and intra-reader reliability.
Optimal design of 850 nm 2×2 multimode interference polymer waveguide coupler by imprint technique
Authors: Shao Yuchen , Han Xiuyou , Han Xiaonan , Lu Zhili , Wu Zhenlin , Teng Jie , Wang Jinyan , Morthier Geert , Zhao Mingshan 
Published: August 2016

AbstractA 2×2 optical waveguide coupler at 850 nm based on the multimode interference (MMI) structure with the polysilsesquioxanes liquid series (PSQ-Ls) polymer material and the imprint technique is presented. The influence of the structural parameters, such as the single mode condition, the waveguide spacing of input/output ports, and the width and length of the multimode waveguide, on the optical splitting performance including the excess loss and the uniformity is simulated by the beam propagation method. By inserting a taper section of isosceles trapezoid between the single mode and multimode waveguides, the optimized structural parameters for low excess loss and high uniformity are obtained with the excess loss of‒0.040 dB and the uniformity of‒0.007 dB. The effect of the structure deviations induced during the imprint process on the optical splitting performance at different residual layer thicknesses is also investigated. The analysis results provide useful instructions for the waveguide device fabrication.
B‐vitamins are potentially a cost‐effective population health strategy to tackle dementia: Too good to be true?
Authors: Tsiachristas Apostolos , Smith A. David 
Published: August 2016

AbstractIntroductionTo respond to the threat of dementia to public health and the economy, we need to prioritize research resources on strategies that would be the most effective. In relation to the prevention of dementia, this article considers whether lowering plasma homocysteine by B‐vitamin supplementation is one of the top priority and cost‐effective treatments.MethodA decision model was constructed to calculate the lifetime costs and quality‐adjusted life years (QALYs) of providing B‐vitamin treatment to people in the United Kingdom over 60 years with high levels (>13 μmol/L) of plasma homocysteine, which was compared to the lifetime costs and outcomes of not providing them with the treatment.ResultsTreatment with B‐vitamins will save £60,021 per QALY gained and so is highly cost‐effective.DiscussionWe anticipate that this provocative finding will be debated by scientists, clinicians, and policy makers and eventually be tested in future clinical trials.
Corporate reputation, social performance, and organizational variability in an emerging country perspective
Authors: Ghosh Koustab 
Published: August 2016

AbstractThis study estimated and specified a model of corporate reputation, its social performance, and firm-level variables in the context of an emerging country. Corporate reputation is the overall estimation of a firm by its stakeholders expressed by the demonstrative behaviors to its customers, employees, investors, business partners, and general public. The social performance of the firm has been conceptualized in terms of its demonstrative responsible behavior toward community, environment, and employees. Organizational variability has been captured in this study through the representation of firms from various industries as the relationship between corporate reputation and firm’s social performance was contingent on the type of industry and expectation of industry-specific stakeholders relevant to the firm. Data were collected from 220 organizations representing 11 different industry verticals. The findings supported that corporate reputation is determined by the conjoint influence of a host of firm specific as well as its social performance factors. In addition, the reputational effect of firm’s social performance was found to vary both across and within sectors, according to the various types of social performance activities the firm was engaged in. This study demonstrated the comprehensive measures of the firm’s reputation, social performance, and the associative relationship between them conditioned by firm-specific attributes and nature of the industry. The study has far reaching implications in terms of managing the firm’s boundary spanning activities and relationships in the perspective of emerging markets.
The effects of almond consumption on fasting blood lipid levels: a systematic review and meta-analysis of randomised controlled trials
Authors: Musa-Veloso Kathy , Paulionis Lina , Poon Theresa , Lee Han Youl 
Published: August 2016

AbstractA systematic review and meta-analysis of randomised controlled trials was undertaken to determine the effects of almond consumption on blood lipid levels, namely total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG and the ratios of TC:HDL-C and LDL-C:HDL-C. Following a comprehensive search of the scientific literature, a total of eighteen relevant publications and twenty-seven almond-control datasets were identified. Across the studies, the mean differences in the effect for each blood lipid parameter (i.e. the control-adjusted values) were pooled in a meta-analysis using a random-effects model. It was determined that TC, LDL-C and TAG were significantly reduced by −0·153 mmol/l (P < 0·001), −0·124 mmol/l (P = 0·001) and −0·067 mmol/l (P = 0·042), respectively, and that HDL-C was not affected (−0·017 mmol/l; P = 0·207). These results are aligned with data from prospective observational studies and a recent large-scale intervention study in which it was demonstrated that the consumption of nuts reduces the risk of heart disease. The consumption of nuts as part of a healthy diet should be encouraged to help in the maintenance of healthy blood lipid levels and to reduce the risk of heart disease.
Determinants of consumption-day amounts applicable for the estimation of usual dietary intake with a short 24-h food list
Authors: Freese Johanna , Pricop-Jeckstadt Mihaela , Heuer Thorsten , Clemens Matthias , Boeing Heiner , Knüppel Sven , Nöthlings Ute 
Published: August 2016

AbstractNext to the information on frequency of food consumption, information on consumption-day amounts is important to estimate usual dietary intake in epidemiological studies. Our objective was to identify determinants of consumption-day amounts to derive person-specific standard consumption-day amounts applicable for the estimation of usual dietary intake using separate sources to assesss information on consumption probability and amount consumed. 24-h Dietary recall data from the German National Nutrition Survey II (n = 8522; aged 20–80 years) conducted between 2005 and 2007 were analysed for determinants of consumption-day amounts of thirty-eight food and beverage groups using LASSO variable selection for linear mixed-effects models. Determinants included sex, age, BMI, smoking status, years of education, household net income, living status and employment status. Most often, sex, age and smoking status were selected as predictors for consumption-day amounts across thirty-eight food groups. In contrast, living with a partner, employment status and household net income were less frequently chosen. Overall, different determinants were of relevance for different food groups. The number of selected determinants ranged from eight for coffee and juice to zero for cabbage, tea, root vegetables, leafy vegetables, fruit vegetables, legumes, offal, vegetable oils, and other fats. For the estimation of usual dietary intake in a combined approach with a 24-h food list, person-specific standard consumption-day amounts could be used. Sex, age and smoking status were shown to be the most relevant predictors in our analysis. Their impact on the estimation of usual dietary intake needs to be evaluated in future studies.
THE COMPLEMENTS OF LOWER CONES OF DEGREES AND THE DEGREE SPECTRA OF STRUCTURES
Authors: ANDREWS URI , CAI MINGZHONG , KALIMULLIN ISKANDER SH. , LEMPP STEFFEN , MILLER JOSEPH S. , MONTALBÁN ANTONIO 
Published: August 2016

AbstractWe study Turing degrees a for which there is a countable structure ${\cal A}$ whose degree spectrum is the collection {x : x ≰ a}. In particular, for degrees a from the interval [0′, 0″], such a structure exists if a′ = 0″, and there are no such structures if a″ > 0‴.
ON PRODUCTS OF ELEMENTARILY INDIVISIBLE STRUCTURES
Authors: MEIR NADAV 
Published: August 2016

AbstractWe say a structure ${\cal M}$ in a first-order language ${\cal L}$ is indivisible if for every coloring of its universe in two colors, there is a monochromatic substructure ${\cal M}\prime \subseteq {\cal M}$ such that ${\cal M}\prime \cong {\cal M}$. Additionally, we say that ${\cal M}$ is symmetrically indivisible if ${\cal M}\prime$ can be chosen to be symmetrically embedded in ${\cal M}$ (that is, every automorphism of ${\cal M}\prime$ can be extended to an automorphism of ${\cal M}$). Similarly, we say that ${\cal M}$ is elementarily indivisible if ${\cal M}\prime$ can be chosen to be an elementary substructure. We define new products of structures in a relational language. We use these products to give recipes for construction of elementarily indivisible structures which are not transitive and elementarily indivisible structures which are not symmetrically indivisible, answering two questions presented by A. Hasson, M. Kojman, and A. Onshuus.
Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression
Authors: de Vries Y. A. , Roest A. M. , Franzen M. , Munafò M. R. , Bastiaansen J. A. 
Published: August 2016

BackgroundCaspi et al.'s 2003 report that 5-HTTLPR genotype moderates the influence of life stress on depression has been highly influential but remains contentious. We examined whether the evidence base for the 5-HTTLPR–stress interaction has been distorted by citation bias and a selective focus on positive findings.MethodA total of 73 primary studies were coded for study outcomes and focus on positive findings in the abstract. Citation rates were compared between studies with positive and negative results, both within this network of primary studies and in Web of Science. In addition, the impact of focus on citation rates was examined.ResultsIn all, 24 (33%) studies were coded as positive, but these received 48% of within-network and 68% of Web of Science citations. The 38 (52%) negative studies received 42 and 23% of citations, respectively, while the 11 (15%) unclear studies received 10 and 9%. Of the negative studies, the 16 studies without a positive focus (42%) received 47% of within-network citations and 32% of Web of Science citations, while the 13 (34%) studies with a positive focus received 39 and 51%, respectively, and the nine (24%) studies with a partially positive focus received 14 and 17%.ConclusionsNegative studies received fewer citations than positive studies. Furthermore, over half of the negative studies had a (partially) positive focus, and Web of Science citation rates were higher for these studies. Thus, discussion of the 5-HTTLPR–stress interaction is more positive than warranted. This study exemplifies how evidence-base-distorting mechanisms undermine the authenticity of research findings.
TOP TEN RESEARCH PRIORITIES FOR ATTENTION DEFICIT/HYPERACTIVITY DISORDER TREATMENT
Authors: Jacobson Stella , Östlund Pernilla , Wallgren Lena , Österberg Marie , Tranæus Sofia 
Published: August 2016

Objectives: The aim of this project was to identify the ten most important research questions for attention deficit/hyperactivity disorder (ADHD) treatment as identified by people with ADHD together with personnel involved in the treatment of ADHD in school, health, and correction services.Methods: A working group consisting of consumers and personnel was established. The method for prioritization was primarily based on James Lind Alliance's guidebook, consisting of an interim priority setting exercise and a workshop.Results: The top ten list includes the risk of drug dependency later in life when treated with methylphenidate as a child, teacher support, multimodal therapy, comparisons between atomoxetine and methylphenidate, methylphenidate treatment in substance abusers, parental support programmes, supported conversation, computer-aided working memory training, psychoeducative treatment, and melatonin.Conclusions: We have shown that consumers and personnel can reach consensus on research priorities for treatments for ADHD. We encourage researchers and funders to consider the list for future studies.
Molecular epidemiology of Crimean-Congo haemorrhagic fever virus in India
Authors: SINGH P. , CHHABRA M. , SHARMA P. , JAISWAL R. , SINGH G. , MITTAL V. , RAI A. , VENKATESH S. 
Published: August 2016

SUMMARYCrimean-Congo haemorrhagic fever (CCHF) is an emerging zoonotic disease in India which is prevalent in neighbouring countries. CCHF virus (CCHFV) is a widespread tick-borne virus which is endemic in Africa, Asia, Eastern Europe and the Middle East. In the present study, samples of clinically suspected human cases from different areas of northern-western India were tested for the presence of CCHFV by RT–PCR through amplification of nucleocapsid (N) gene of CCHFV. Positive samples were sequenced to reveal the prevailing CCHFV genotype(s) and phylogenetic relatedness. A phylogenetic tree revealed the emergence of diverse strains in the study region showing maximum identity with the Pakistan, Afghanistan and Iran strains, which was different from earlier reported Indian strains. Our findings reveal for the first time the emergence of the Asia 1 group in India; while earlier reported CCHFV strains belong to the Asia 2 group.