bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlating pre‐operative MRI measurements of metatarsal Osteomyelitis with surgical clean margins reveals the need for a one centimeter resection margin
Authors: Bernstein Brent , Stouder Melody , Bronfenbrenner Eric , Chen Steven , Anderson David 
Published: August 2017

AbstractBackgroundDue to the high incidence of forefoot ulcerations with associated osteomyelitis, there has been an increased demand for partial ray amputations. In order to ensure complete removal of infected metatarsal bone, a clean margin amount is chosen based on the surgeon's intraoperative visual subjective evaluation. The margin is resected and sent to pathology. Currently the literature shows positive proximal margin rates of 35–40%. The purpose of this study was to reduce the rate of positive proximal margins by effectively resecting all infected bone using pre‐operative MRI measurements with an added resection margin.MethodsTwenty‐four osteomyelitis positive metatarsals were included in this exploratory study. The distance of proximal osteomyelitic extension within the metatarsal was measured on MRI in centimeters. Intra‐operatively, the partial ray amputation cut was determined by adding an extra 0.5 cm resection margin to the MRI measurement. At the study's mid‐point, bone histopathology revealed an increase in positive proximal margin rates‐so the resection margin was increased to 1 cm. Descriptive outcomes included the mean distance of osteomyelitis propagation, proximal margin rates, as well as diagnostic statistics.ResultsAfter removing the specimens with false positive MRI results, the study sample included 21 metatarsals positive for osteomyelitis. A 0.5 cm resection margin proximal to the osteomyelitis resulted in a 50% positive proximal margin rate. After increasing the resection margin to 1 cm, there was found to be an improved positive proximal margin rate of 9%. Based on MRI findings, the mean distance + standard deviation of osteomyelitis propagation along the metatarsal proximally was 1.81 cm + 0.74 cm. The metatarsal specimen was processed by pathology into multiple pieces and compared to MRI, resulting in MRI sensitivity of 67%, specificity of 74%, positive predictive value of 79%, and negative predictive value of 60%.ConclusionsBy performing a 1 cm resection margin proximal to the metatarsal osteomyelitis the proximal margin rate was reduced to clinically meaningful levels. These preliminary findings support using a 1 cm resection margin when performing any form of metatarsal amputation, to reduce the risk of residual osteomyelitis post‐operatively.Trial registrationSt. Luke's Hospital, IRB National Protocol ID SLHN2015–112. Date:1–13‐16.
Monitoring of the daily living activities in smart home care
Authors: Vanus Jan , Belesova Jana , Martinek Radek , Nedoma Jan , Fajkus Marcel , Bilik Petr , Zidek Jan 
Published: August 2017

AbstractOne of the key requirements for technological systems that are used to secure independent housing for seniors in their home environment is monitoring of daily living activities (ADL), their classification, and recognition of routine daily patterns and habits of seniors in Smart Home Care (SHC). To monitor daily living activities, the use of a temperature, CO2, humidity sensors, and microphones are described in experiments in this study. The first part of the paper describes the use of CO2 concentration measurement for detecting and monitoring room´s occupancy in SHC. In second part focuses this paper on the proposal of an implementation of Artificial Neural Network based on the Levenberg–Marquardt algorithm (LMA) for the detection of human presence in a room of SHC with the use of predictive calculation of CO2 concentrations from obtained measurements of temperature (indoor, outdoor) Ti, To and relative air humidity rH. Based on the long-term monitoring (1 month) of operational and technical functions (unregulated, uncontrolled) in an experimental Smart Home (SH), LMA was trained through the data picked up by the sensors of CO2, T and rH with the aim to indirectly predict CO2 leading to the elimination of CO2 sensor from the measurement process. Within the realized experiment, input parameters of the neuronal network and the number of neurons for LMA were optimized on the basis of calculated values of Root Mean Squared Error, the correlative coefficient (R) and the length of the measured training time ANN. With the use of the trained network ANN, we realized a strictly controlled short-term (11 h) experiment without the use of CO2 sensor. Experimental results verified high method accuracy (>95%) within the short-term and long-term experiments for learned ANN (1.6.2015–30.6.2015). For learned ANN (1.2.2014–27.2.2014) was verified worse method accuracy (>60%). The original contribution is a verification of a low-cost method for the detection of human presence in the real operating environment of SHC. In the third part of the paper is described the practical implementation of voice control of operating technical functions by the KNX technology in SHC by means of the in-house developed application HESTIA, intended for both the desktop system version and the mobile version of the Windows 10 operating system for mobile phones. The resultant application can be configured for any building equipped with the KNX bus system. Voice control implementation is an in-house solution, no third-party software is used here. Utilization of the voice communication application in SHC was proven on the experimental basis with the combination of measurement CO2 for ADL monitoring in SHC.
Leveraging Mobile Technology to Improve Efficiency of the Consent-to-Treatment Process
Authors: Chhin Veng , Roussos Jerry , Michaelson Terry , Bana Mazaheer , Bezjak Andrea , Foxcroft Sophie , Hamilton Jasmine L. , Liu Fei-Fei 
Published: August 2017

Purpose This study reports on the implementation of an electronic consent-to-treatment system (e-Consent) in a busy radiation medicine program and compares it with the previous paper-based method of documenting patient consent. Methods A password-protected, electronic, e-Consent application was designed in-house and installed on iPad devices to document patient consent for radiation therapy treatments. A feasibility study, followed by a program-wide deployment of e-Consent, was executed. The effectiveness and impact of e-Consent on workflow were determined by comparing the number of problems arising from the paper-based consenting method with those from the e-Consent process. Staff satisfaction and perceived impact of e-Consent on workflow were determined by a program-wide survey of e-Consent users. Results The e-Consent completion rate was 94.2% (5,600 of 5,943 forms) 1 year after implementation, indicating successful uptake at the program level. Although the paper-based method of documenting patient consent was associated with an error rate of 7% (24 of 343 forms), e-Consent was associated with an error rate of 0.32% (18 of 5,600 forms) 1 year after deployment. Results of a 10-item e-Consent user survey indicated improvement in staff workflow and high overall satisfaction with e-Consent. Conclusion e-Consent is more efficient than paper-based methods for documenting patient consent. Moreover, replacing paper-based consent methods with an electronic version facilitated an improved workflow and staff satisfaction. Efforts aimed at implementing e-Consent throughout the entire cancer program are currently underway.
Risk of Alzheimer’s Disease Among Senior Medicare Beneficiaries Treated With Androgen Deprivation Therapy for Prostate Cancer
Authors: Baik Seo Hyon , Kury Fabricio Sampaio Peres , McDonald Clement Joseph 
Published: August 2017

Purpose To assess the relative risk of Alzheimer’s disease (AD) among patients with prostate cancer who received androgen deprivation therapy (ADT), after adjustment for other cancer therapies. Methods Data from demographics, survival, diagnoses codes, procedure codes, and other information about beneficiaries age 67 years or older in the Medicare claims database was assessed to determine the unadjusted and adjusted risks of AD and of dementia from ADT. The prespecified survival analysis method was competing risk regression. Results Of the 1.2 million fee-for-service Medicare beneficiaries who developed prostate cancer in 2001 to 2014, 35% received ADT. Of these, 109,815 (8.9%) and 223,765 (18.8%) developed AD and dementia, respectively, and 26% to 33% died without either outcome. Unadjusted rates of AD and all-cause mortality per 1,000 patient-years were higher among ADT recipients; the unadjusted rates of AD were 17.0 and 15.5 per 1,000 person-years in recipients and nonrecipients, respectively, and the unadjusted rates of all-cause mortality were 73.0 and 51.6 per 1,000 person-years, respectively. The unadjusted rates for dementia in ADT recipients versus nonrecipients were 38.5 and 32.9, respectively, and the unadjusted rates of mortality were 60.2 versus 40.4, respectively. However, after analysis was adjusted for other cancer therapies and other covariates, patients with ADT treatment had no increased risk of AD (subdistribution hazard ratio [SHR], 0.98; 95% CI, 0.97 to 0.99) and had only a miniscule (1%) risk of dementia (SHR, 1.01; 95% CI, 1.01 to 1.02); patients treated with ADT were more likely to die before progression to AD (SHR, 1.24; 95% CI, 1.23 to 1.24) or dementia (SHR, 1.26; 95% CI, 1.25 to 1.26). The risks of AD and dementia were not associated with duration of ADT (ie, no dose effect). Other secondary analyses confirmed these results. Conclusion These data suggest that ADT treatment has no hazard for AD and no meaningful hazard for dementia among men age 67 years or older who are enrolled in Medicare.
A PGAM5–KEAP1–Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking
Authors: O'Mealey Gary B. , Plafker Kendra S. , Berry William L. , Janknecht Ralf , Chan Jefferson Y. , Plafker Scott M. 
Published: August 2017

ABSTRACT
The Nrf2 transcription factor is a master regulator of the cellular anti-stress response. A population of the transcription factor associates with the mitochondria through a complex with KEAP1 and the mitochondrial outer membrane histidine phosphatase, PGAM5. To determine the function of this mitochondrial complex, we knocked down each component and assessed mitochondrial morphology and distribution. We discovered that depletion of Nrf2 or PGAM5, but not KEAP1, inhibits mitochondrial retrograde trafficking induced by proteasome inhibition. Mechanistically, this disrupted motility results from aberrant degradation of Miro2, a mitochondrial GTPase that links mitochondria to microtubules. Rescue experiments demonstrate that this Miro2 degradation involves the KEAP1–cullin-3 E3 ubiquitin ligase and the proteasome. These data are consistent with a model in which an intact complex of PGAM5–KEAP1–Nrf2 preserves mitochondrial motility by suppressing dominant-negative KEAP1 activity. These data further provide a mechanistic explanation for how age-dependent declines in Nrf2 expression impact mitochondrial motility and induce functional deficits commonly linked to neurodegeneration.
How the personal remains political in photography today
Authors: Brown Camilla 
Published: August 2017

Abstract
There are a startling number of women artists making themselves the subject of their own work today. Many will make it a recurrent theme of their practice; others seem to go through a phase, either early or late on in their careers, where they feature themselves in their work. This might be an inevitable by-product of feminist studies, a subject covered in most art schools. Women artists grapple with theories about the engendered male gaze and attempt to position themselves within it. For young women artists it can almost be a rite of passage through which they must pass to find their own artistic voice. It could simply be due to the resurgence of interest in performance art in contemporary practice that leads so many female artists to use their own bodies as a tool for their work. This article sparked by the Evidence conference at FORMAT 2015 will consider the political implications of this use of the self. Four women artists using photography, all working in the United Kingdom, have been selected: Trish Morrissey, Sian Bonnell, E. J. Major and Melanie Manchot. Their work is taken as a starting point for some thinking around this subject. Each of the artists has been asked to respond to a series of questions and their comments punctuate this text; and I would like to thank them for contributing in this way.
Evidence, memory and the malleable photograph
Authors: Bogre Michelle 
Published: August 2017

Abstract
This article explores the capacity of the photograph to furnish evidence, which derives both from its indexicality and from the visual accuracy of the raw image. Photographs achieve the status of evidence not because the photograph itself has any implicit identity but rather because the State recognized that the photograph could provide proof of identification – mug shots – as early as 1850 when police departments hired photographers to take mug shots and crime scene photographs. Courts accepted the photograph as evidence as early as 1859 and continue today, even employing ‘Instagram’ officers whose job entails monitoring Instagram accounts of persons of interest. The article then explores why the photograph remains believable today to the public even with contemporary discourse about the malleability of the photograph.
In pursuit of autonomy: Autonomia and the archive
Authors: Caruth Scott 
Published: August 2017

Abstract
The Historical Archives of the Fondazione Fotografia contain over half a million photographic objects relating to the northern Italian town of Modena. Adopting all types of photographic processes and dealing with a broad range of subject matter, the collection details shifts and currents within both the photographic medium and the social and political landscape of the town itself. This article stems from the period in which I was artist in residence at the Fondazione Fotografia earlier this year. During this time, I attempted to trace the regions prominent yet ambiguous radical politics of the 1970s and the early 1980s, particularly the ‘Autonomia’ movement, through the context of the photographic archive. This research seeks to reflect on this process and undertake an exploration of the movement in relation to the archival enterprise, particularly the ways in which the wider concept of the archive as a framework presents issues that intersect with those dealt with by the movement itself. In doing so, I investigate the role played by the archive in the establishment of historical and political narratives and the ways in which it both constitutes and reinforces structures of power. The process of tracing Autonomia through such a framework confirms that absence of evidence is not evidence of absence.
Analisis Risiko Paparan Debu Kapas Terhadap Kejadian Bisinosis di Industri Tekstil PT. Grandtex Bandung
Authors: Mulyati Sri Slamet , Setiani Onny , Raharjo Mursid 
Published: August 2017

Background: Byssinosis is still health problems associated with exposure to cotton dust. High risk of health problems in Environmental Health Risk Assessment is expressed as a Risk Quotenit (RQ) .Work activities, the use of personal protective equipment, and psychological disorder may also affect the incidence of byssinosis. Methods: This was an observational research with cross sectional design. The population in this research are all employees of PT.Grandtex.Eighty workers from morning shifts only were randomly selected. Each worker was examined of the FEV1 and FVC. Questionnaires structured was another tools for collecting data.Total dust measured in the working environments and ambient air.Results: The results by Chi-Square test showed significant relation between the Risk Quotenit (RQ) with byssinosis (p-value 0.043; PR 1,8 (95%CI : 0.95-3.52),have a significant relationship between work activities with byssinosis (p-value 0.035; PR 2.2 (95%CI : 0.86-5.85)have a significant relationship between the use of personal protective equipment with byssinosis (p-value 0.001; PR 2.9 (95%CI : 1.21-6.81) and have a significant relationship between psychological disorders with byssinosis (p-value 0.023; PR 1,7 (95%CI : 1.28-2.14)Conclusion: The number of worker with positive Byssinosis symptoms and abnormal lung function 15 people(18.75%) , positive Byssinosis symptoms and normal lung function 35people(43.75%) Keywords : Byssinosis, cotton dust, risk assessment
Results of the first external quality assessment scheme (EQA) for isolation and analysis of circulating tumour DNA (ctDNA)
Authors: Haselmann Verena , Ahmad-Nejad Parviz , Geilenkeuser Wolf J. , Duda Angelika , Gabor Merle , Eichner Romy , Patton Simon , Neumaier Michael 
Published: August 2017

AbstractBackground:Circulating tumour DNA (ctDNA) is considered to have a high potential for future management of malignancies. This pilot external quality assessment (EQA) scheme aimed to address issues of analytical quality in this new area of laboratory diagnostics.Methods:The EQA scheme consisted of three 2-mL EDTA-plasma samples spiked with fragmented genomic DNA with a mutant allele frequency ranging from 0% to 10% dedicated to the analysis of nine known sequence variations inKRAScodon 12/13 and ofBRAFV600E. Laboratories reported: (1) time elapsed for processing, (2) storage temperatures, (3) methods for extraction and quantification, (4) genotyping methodologies and (5) results.Results:Specimens were sent to 42 laboratories from 10 European countries; 72.3% reported to isolate cell-free DNA (cfDNA) manually, 62.5% used the entire plasma volume for cfDNA isolation and 38.5% used >10% of cfDNA extracted for downstream genotyping. Of the methods used for quantification, PicoGreen demonstrated the lowest coefficient of variation (33.7%). For genotyping, 11 different methods were reported with the highest error rate observed for Sanger sequencing and the lowest for highly sensitive approaches like digital PCR. In total, 197 genotypes were determined with an overall error rate of 6.09%.Conclusions:This pilot EQA scheme illustrates the current variability in multiple phases of cfDNA processing and analysis of ctDNA resulting in an overall error rate of 6.09%. The areas with the greatest variance and clinical impact included specimen volume, cfDNA quantification method, and preference of genotyping platform. Regarding quality assurance, there is an urgent need for harmonisation of procedures and workflows.
High Throughput Line-of-Sight MIMO Systems for Next Generation Backhaul Applications
Authors: Song Xiaohang , Cvetkovski Darko , Hälsig Tim , Rave Wolfgang , Fettweis Gerhard , Grass Eckhard , Lankl Berthold 
Published: August 2017

Abstract
The evolution to ultra-dense next generation networks requires a massive increase in throughput and deployment flexibility. Therefore, novel wireless backhaul solutions that can support these demands are needed. In this work we present an approach for a millimeter wave line-of-sight MIMO backhaul design, targeting transmission rates in the order of 100 Gbit/s. We provide theoretical foundations for the concept showcasing its potential, which are confirmed through channel measurements. Furthermore, we provide insights into the system design with respect to antenna array setup, baseband processing, synchronization, and channel equalization. Implementation in a 60 GHz demonstrator setup proves the feasibility of the system concept for high throughput backhauling in next generation networks.
Faktenorientiertes Lernen, Perspektivenübernahme und der Umgang mit Deutungen in asynchronen Online-Diskussionen zu Gründungsmythen
Authors: Becker Christine 
Published: August 2017

Zusammenfassung
Im Artikel werden erste Ergebnisse einer überwiegend qualitativ ausgerichteten empirischen Studie zu landeskundlichem Lernen in asynchronen Online-Diskussionen zusammengefasst. Die Diskussionen waren Teil der Online-Phasen eines kulturwissenschaftlich orientierten universitären Fachseminars zur Landeskunde der deutschsprachigen Länder. Ausgehend von der Aufgabenstellung liegt der Fokus dieser Ergebnispräsentation auf der Frage, wie sich die Studierenden mit der Bedeutung von historischen Ereignissen, die später den Status von Gründungsmythen erhielten, im Forum auseinandersetzen. Es werden so kulturbezogene Aushandlungsprozesse in der Unterrichtspraxis nachvollzogen, z. B. wird aufgezeigt, wie in einer durch die Aufgabenstellung angeregten Perspektivenübernahme eigenkulturelle Deutungsmuster herangezogen werden oder Übergeneralisierungen stattfinden. Im abschließenden Fazit werden Implikationen der Forschungsergebnisse für die Unterrichtspraxis diskutiert.
Deutschlernen und die Entstehung und Veränderung von Stereotypen ägyptischer Deutschlerner
Authors: Mahmoud Karim 
Published: August 2017

Zusammenfassung
: In dem vorliegenden Beitrag wird ein Dissertationsprojekt, das seit Oktober 2013 am Herder-Institut der Universität Leipzig durchgeführt wird, vorgestellt. Dabei wird untersucht, inwieweit die Stereotype ägyptischer Deutschlerner durch das Deutschlernen an Bildungseinrichtungen in Ägypten beeinflusst werden und welche grundlegenden Faktoren dabei eine bestimmende Rolle spielen? Zunächst wird der Begriff Stereotyp näher erörtert in Zusammenhang mit einem Überblick der relevanten Literatur zum Thema, gefolgt von der Beschreibung des Projekts. Im Anschluss daran folgt der empirische Teil, insbesondere mit den Ergebnissen des ersten Erhebungszeitpunkts.
„Den Lernern eine eigene Stimme geben...“ Relevante Konzepte Bachtins für das kulturelle Lernen im Fremdsprachenunterricht
Authors: Voerkel Paul , Janzen Henrique Evaldo 
Published: August 2017

Zusammenfassung
Eine Herausforderung für die Kulturstudien im Fach Deutsch als Fremdsprache (DaF) liegt darin, über theoretische Forschungsansätze hinaus auch bereits bestehende Projekte und Praxisbeispiele des kulturellen Lernens im Fremdsprachenunterricht wahrzunehmen und zu berücksichtigen. Ländern außerhalb des deutschsprachigen Raumes kommt bei der Erarbeitung und Umsetzung entsprechender Konzepte eine besondere Rolle zu, stehen die Lehrkräfte dort doch vor der Aufgabe, fremdsprachliches und kulturelles Lernen anzuregen, ohne dass die Lerner die Zielsprachenkultur in ihrem alltäglichen Umfeld erfahren könnten. Aus dieser Situation heraus wird an der Bundesuniversität UFPR in Brasilien seit einigen Jahren mit einem empirischen, qualitativ orientierten Ansatz in der Deutschlehrerausbildung gearbeitet. Bei der eigenständigen Erarbeitung von Unterrichtsmaterialien gehen die Studierenden der Frage nach, wie bestimmte Diskursmuster und Darstellungen in Lehrwerken das kulturelle Lernen beeinflussen. Grundlage der Lehrveranstaltung sind einige der zentralen Konzepte des russischen Literaturwissenschaftlers Michail Bachtin. Der Artikel beschreibt einerseits ihr Potenzial für einen lernerorientierten, poststrukturalistischen Fremdsprachenunterricht in Brasilien, andererseits zeigt er mögliche Verknüpfungen mit aktuellen Ansätzen der DaF-Kulturdidaktik auf.