bluuebunny/crossref_metadata_2025_split huggingface dataset:
Goldilocks versus Goldlöckchen: Visual speech preference for same‐rhythm‐class languages in 6‐month‐old infants
Authors: Kubicek Claudia , Gervain Judit , Lœvenbruck Hélène , Pascalis Olivier , Schwarzer Gudrun 
Published: January 2018

AbstractThe present study investigated German‐learning 6‐month‐old infants' preference for visual speech. Visual stimuli in the infants' native language (German) were contrasted with stimuli in a foreign language with similar rhythmical characteristics (English). In a visual preference task, infants were presented with 2 side‐by‐side silent video clips of the same speaker reciting a nursery rhyme simultaneously in German and English. To assess spontaneous preference for native or non‐native visual speech, we computed preference scores towards the English‐ and German‐speaking faces. The findings of the present study revealed a sex difference in visual speech preference. Only female infants exhibited a visual preference, by attending longer to the English‐speaking face. Notably, the present study provides the first evidence for sex differences in visual speech preference in infancy.Highlights

Visual speech preference was tested in 6‐month‐old German‐learning infants.
Infants were tested with a preferential looking task contrasting German and English language.
Only female infants displayed a visual preference toward English visual speech suggesting a sex difference in infants' visual speech processing.
Front Cover: A theoretical‐experimental methodology for assessing the sensitivity of biomedical spectral imaging platforms, assays, and analysis methods (J. Biophotonics 1/2018)
Authors: Leavesley Silas J. , Sweat Brenner , Abbott Caitlyn , Favreau Peter , Rich Thomas C. 
Published: January 2018

A hyperspectral image data cube acquired from HEK‐293 cells labeled with cytoplasmic and nuclear stains: Calcein Green and NucBlu. The top view (XY plane) displays three spectrally unmixed channels for cellular autofluorescence (red), Calcein Green (green), and NucBlue (blue). The Z axis shows spectral information, from low to high wavelength. The article by Leavesley and colleagues describes an approach for calculating the sensitivity of spectral imaging assays for detecting a fluorescence signature within a mix of other signatures or autofluorescence. Further details can be found in the article by Silas J. Leavesley et al. (e201600227).
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Cx43 Overexpression in Osteocytes Prevents Osteocyte Apoptosis and Preserves Cortical Bone Quality in Aging Mice
Authors: Davis Hannah M , Aref Mohammad W , Aguilar‐Perez Alexandra , Pacheco‐Costa Rafael , Allen Kimberly , Valdez Sinai , Herrera Carmen , Atkinson Emily G , Mohammad Arwa , Lopez David , Harris Marie A , Harris Stephen E , Allen Matthew , Bellido Teresita , Plotkin Lilian I 
Published: January 2018

ABSTRACTYoung, skeletally mature mice lacking Cx43 in osteocytes exhibit increased osteocyte apoptosis and decreased bone strength, resembling the phenotype of old mice. Further, the expression of Cx43 in bone decreases with age, suggesting a contribution of reduced Cx43 levels to the age‐related changes in the skeleton. We report herein that Cx43 overexpression in osteocytes achieved by using the DMP1‐8kb promoter (Cx43OT mice) attenuates the skeletal cortical but not trabecular bone phenotype of aged, 14‐month‐old mice. The percentage of Cx43‐expressing osteocytes was higher in Cx43OT mice, whereas the percentage of Cx43‐positive osteoblasts remained similar to wild‐type (WT) littermate control mice. The percentage of apoptotic osteocytes and osteoblasts was increased in aged WT mice compared with skeletally mature, 6‐month‐old WT mice, and the percentage of apoptotic osteocytes, but not osteoblasts, was decreased in age‐matched Cx43OT mice. Aged WT mice exhibited decreased bone formation and increased bone resorption as quantified by histomorphometric analysis and circulating markers compared with skeletally mature mice. Further, aged WT mice exhibited the expected decrease in bone biomechanical structural and material properties compared with young mice. Cx43 overexpression prevented the increase in osteoclasts and decrease in bone formation on the endocortical surfaces and the changes in circulating markers in the aged mice. Moreover, the ability of bone to resist damage was preserved in aged Cx43OT mice both at the structural and material level. All together, these findings suggest that increased Cx43 expression in osteocytes ameliorates age‐induced cortical bone changes by preserving osteocyte viability and maintaining bone formation, leading to improved bone strength. © 2018 American Society for Bone and Mineral Research.
Impact of Ownership Patterns and Firm Life‐Cycle Stages on Firm Performance: Evidence From India
Authors: Sridharan Srividhya , Joshi Medha 
Published: January 2018

This article reexamines the relationship between ownership patterns and firm financial performance through the prism of firm life‐cycle stages. We use an unbalanced panel data set from the S&P BSE 500 companies in the emerging Indian market over nine years. We adopt multivariate analysis with covariance to explore the relationship between ownership patterns and firm performance across various stages of a firm's life cycle. Empirical results suggest that firm life cycle is a key indicator in the study of relationship between ownership patterns and firm performance. Performance is optimized by different patterns of ownership over different life‐cycle stages. Closely held firms perform better than widely held firms, and those with foreign promoter holdings outperform in most life‐cycle stages.	© 2018 Wiley Periodicals, Inc.
Rating the quality of a body of evidence on the effectiveness of health and social interventions: A systematic review and mapping of evidence domains
Authors: Movsisyan Ani , Dennis Jane , Rehfuess Eva , Grant Sean , Montgomery Paul 
Published: January 2018

IntroductionRating the quality of a body of evidence is an increasingly common component of research syntheses on intervention effectiveness. This study sought to identify and examine existing systems for rating the quality of a body of evidence on the effectiveness of health and social interventions.MethodsWe used a multicomponent search strategy to search for full‐length reports of systems for rating the quality of a body of evidence on the effectiveness of health and social interventions published in English from 1995 onward. Two independent reviewers extracted data from each eligible system on the evidence domains included, as well as the development and dissemination processes for each system.ResultsSeventeen systems met our eligibility criteria. Across systems, we identified 13 discrete evidence domains: study design, study execution, consistency, measures of precision, directness, publication bias, magnitude of effect, dose‐response, plausible confounding, analogy, robustness, applicability, and coherence. We found little reporting of rigorous procedures in the development and dissemination of evidence rating systems.ConclusionWe identified 17 systems for rating the quality of a body of evidence on intervention effectiveness across health and social policy. Existing systems vary greatly in the domains they include and how they operationalize domains, and most have important limitations in their development and dissemination. The construct of the quality of the body of evidence was defined in a few systems largely extending the Grading of Recommendations Assessment, Development, and Evaluation approach. Grading of Recommendations Assessment, Development, and Evaluation was found to be unique in its comprehensive guidance, rigorous development, and dissemination strategy.
The ScienceDirect accessibility journey: A case study
Authors: Gies Ted 
Published: January 2018

Key points
Policy, top–down support, educational working groups, customer data, and a central accessibility team have helped mature web accessibility at Elsevier ScienceDirect.
Collaboration groups are essential for gathering feedback from users with disabilities and experts in the field.
Many of the lessons learned from the first accessibility user study in 2001 are still relevant today.
Alt text for figures is a challenge for publishers, and using authors or machine learning to provide text descriptions may be a solution.
Accessibility is not an achievement to be won and done but a culture paradigm that integrates inclusive design into the very early phases of a product.
Beyond the mandates: The far‐reaching benefits of multimedia accessibility
Authors: Iglesias Violaine 
Published: January 2018

Key points
Convergence of international standards has made requirements for accessible multimedia content clearer.
Legal and commercial pressure for accessible content is mounting for higher education institutions (HEIs) and publishers as highlighted by recent high‐profile settlements in North America.
Accessibility requirements for multimedia can be met by setting realistic, progressive goals and focusing resources on key content.
Multimedia accessibility benefits range from wider audiences and increased user engagement to greater discoverability and improved search engine optimization.
Vendors are ramping up their offerings for accessible production, and costs are going down.
Synergetic Effects of Prenatal and Postnatal High Sucrose Intake on Glucose Tolerance and Hepatic Insulin Resistance in Rat Offspring
Authors: Zhang Pengjie , Zhu Di , Zhang Yueming , Li Lingjun , Chen Xionghui , Zhang Wenna , Shi Ruixiu , Tao Jianying , Han Bing , Xu Zhice 
Published: January 2018

ScopeHigh sucrose intake during pregnancy is linked to type 2 diabetes mellitus and altered insulin resistance.Methods and resultsThis study attempts to ascertain whether prenatal high sucrose intake (20% sucrose) alleviates the detrimental effects of high postnatal sugar consumption in the offspring, and the molecular mechanisms are investigated using a rat model. High prenatal sucrose exposure increases the body weight of the offspring at 1–3 weeks of age. Exposure to both prenatal and postnatal high sucrose increases glucose tolerance in the 4‐month‐old adult offspring compared with offspring receiving other treatments. Postnatal high sucrose exposure suppresses food intake but increases the total daily caloric and fluid intake. Both fasting blood glucose and plasma triglyceride levels are increased, but the fasting insulin level is unaffected. Prenatal high sucrose intake enlarges pancreatic islet area; however, prenatal‐plus‐postnatal high sucrose exposure induces smaller pancreatic islets. IRS‐1(S612) protein phosphorylation is significantly increased, and the GSK‐3β (S9) phosphorylation level is reduced.ConclusionBoth prenatal and prenatal‐plus‐postnatal high sucrose exposure substantially affect biological functions related to insulin homeostasis. IRS‐1(S612) protein phosphorylation appears to be a part of the molecular mechanism underlying these effects. These results add to the understanding of how high sucrose intake contributes to insulin resistance and diabetes pathogenesis and how postnatal nutrition and lifestyle may mitigate detrimental prenatal exposures.
A Closed‐Loop Control Strategy for Producing Nitrile Rubber of Uniform Chemical Composition in a Semibatch Reactor: A Simulation Study
Authors: Clementi Luis A. , Suvire Romina B. , Rossomando Francisco G. , Vega Jorge R. 
Published: January 2018

AbstractTo improve the quality of industrial nitrile rubbers, the copolymer chemical composition, pA(t), should ideally be kept constant along the reaction. This work proposes a closed‐loop control strategy for the semibatch operation of the reactor with the aim of regulating pA(t) within a reduced range of variability. The proposed strategy is evaluated by simulating a mathematical model of the process. To this effect, a simplified mathematical model of the reaction is first derived and then utilized to obtain a suboptimal control law and a soft‐sensor that estimates the polymerization rates. The suboptimal control law is compensated by adding a term proportional to errors in pA(t). The simulated example considers the production of the low‐composition AJLT grade, with the copolymerization reaction represented by a detailed mathematical model adjusted to an industrial plant. Due to the high performance of the soft‐sensor, the simulation results suggest that the proposed closed‐loop strategy is efficient to adequately regulate pA(t) in spite of structural and parametric uncertainties, while other quality variables remained practically unaffected.
Effect of dys‐1 mutation on gene expression profile in space‐flown Caenorhabditis elegans
Authors: Xu Dan , Gao Ying , Guo Lin , Lin Chenggang , Sun Yeqing 
Published: January 2018

ABSTRACTIntroduction: Dystrophin‐like dys‐1 gene expression increases in the body wall muscles of Caenorhabditis elegans after spaceflight (SF). Here we used a dys‐1(cx18) mutant to analyze the molecular adaptive responses of C. elegans to SF. Methods: DNA microarrays were performed to identify differentially expressed genes between wild‐type (WT) and dys‐1 mutant worms after SF. We performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses, predicted human diseases, and screened out key genes for human muscle diseases with NextBio. Results: Gene expression was less affected by SF in the dys‐1 mutant than in the WT worms. The dys‐1 mutation influenced neuromuscular gene expression (neuropeptide genes, muscle‐related genes, and dystrophin‐related genes) under SF conditions, among which 15 genes were specifically regulated by dys‐1. NextBio analysis predicted that cdka‐1, lev‐11, unc‐27, and unc‐94 genes might play critical roles in muscle atrophy. Discussion: dys‐1 Potentially regulates the neuromuscular system in space. Muscle Nerve 58: 114–122, 2018
Contraceptives as possible risk factors for postpartum depression: A retrospective study of the food and drug administration adverse event reporting system, 2004–2015
Authors: Horibe Megumi , Hane Yuuki , Abe Junko , Matsui Toshinobu , Kato Yamato , Ueda Natsumi , Sasaoka Sayaka , Motooka Yumi , Hatahira Haruna , Hasegawa Shiori , Kinosada Yasutomi , Hara Hideaki , Nakamura Mitsuhiro 
Published: January 2018

AbstractAimPostpartum depression is a mood disorder that commonly affects women during the early postpartum period. The objective of this study was to analyse the association of postpartum depression with drugs (including contraceptive devices and implants) with spontaneously reported adverse events reported in the US Food and Drug Administration Adverse Event Reporting System database.DesignRetrospective study.MethodReports of postpartum depression events between 2004–2015 were analysed with a reporting odds ratio (ROR) algorithm. The Medical Dictionary for Regulatory Activities was used to identify postpartum depression.ResultsThe reporting odds ratios (95% confidence intervals, CI) of levonorgestrel (an intrauterine device with progestogen), etonogestrel (a hormonal contraceptive implant), sertraline and drospirenone (an oral contraceptive) were 12.5 (8.7–18.0), 14.0 (8.5–22.8), 12.2 (6.5–23.1) and 5.4 (2.7–10.9) respectively. Among the drugs in the US Food and Drug Administration Adverse Event Reporting System database, the use of contraceptives or an intrauterine device with progestogen might convey risk for postpartum depression.
Organometallic Nucleosides: Synthesis and Biological Evaluation of Substituted Dicobalt Hexacarbonyl 2′‐Deoxy‐5‐oxopropynyluridines
Authors: Kaczmarek Renata , Korczyński Dariusz , Królewska‐Golińska Karolina , Wheeler Kraig A. , Chavez Ferman A. , Mikus Agnieszka , Dembinski Roman 
Published: January 2018

AbstractReactions of dicobalt octacarbonyl [Co2(CO)8] with 2′‐deoxy‐5‐oxopropynyluridines and related compounds gave dicobalt hexacarbonyl nucleoside complexes (83–31 %). The synthetic outcomes were confirmed by X‐ray structure determination of dicobalt hexacarbonyl 2′‐deoxy‐5‐(4‐hydroxybut‐1‐yn‐1‐yl)uridine, which exhibits intermolecular hydrogen bonding between a modified base and ribose. The electronic structure of this compound was characterized by the DFT calculations. The growth inhibition of HeLa and K562 cancer cell lines by organometallic nucleosides was examined and compared to that by alkynyl nucleoside precursors. Coordination of the dicobalt carbonyl moiety to the 2′‐deoxy‐5‐alkynyluridines led to a significant increase in the cytotoxic potency. The cobalt compounds displayed antiproliferative activities with median inhibitory values (IC50) in the range of 20 to 80 μm for the HeLa cell line and 18 to 30 μm for the K562 cell line. Coordination of an acetyl‐substituted cobalt nucleoside was expanded by using the 1,1‐bis(diphenylphosphino)methane (dppm) ligand, which exhibited cytotoxicity at comparable levels. The formation of reactive oxygen species in the presence of cobalt compounds was determined in K562 cells. The results indicate that the mechanism of action for most antiproliferative cobalt compounds may be related to the induction of oxidative stress.
Role of AP‐endonuclease (Ape1) active site residues in stabilization of the reactant enzyme‐DNA complex
Authors: Batebi Hossein , Dragelj Jovan , Imhof Petra 
Published: January 2018

AbstractApurinic/apyrimidinic endonuclease 1 (Ape1) is an important metal‐dependent enzyme in the base excision repair mechanism, responsible for the backbone cleavage of abasic DNA through a phosphate hydrolysis reaction. Molecular dynamics simulations of Ape1 complexed to its substrate DNA performed for models containing 1 or 2 Mg2+‐ions as cofactor located at different positions show a complex with 1 metal ion bound on the leaving group site of the scissile phosphate to be the most likely reaction‐competent conformation. Active‐site residue His309 is found to be protonated based on pKa calculations and the higher conformational stability of the Ape1‐DNA substrate complex compared to scenarios with neutral His309. Simulations of the D210N mutant further support the prevalence of protonated His309 and strongly suggest Asp210 as the general base for proton acceptance by a nucleophilic water molecule.
Unusual [3+2] Spiroannulation and Creation of Stereogenic Quaternary Center at C‐3 of Oxindole via Addition of (Het)arynes to Isomerized Morita‐Baylis‐Hillman Adduct of Isatin
Authors: Meerakrishna Ramakrishnan Suseela , Athira Mohanakumaran , Shanmugam Ponnusamy 
Published: January 2018

AbstractA one‐pot synthesis of 1′‐methyl‐2′‐oxospiro [indene‐1, 3′‐indoline] and 3,3‐disubstituted 2‐oxindole derivatives in excellent combined yield by the reaction of methoxy isomerized MBH adducts of isatin with arynes and heteroarynes has been achieved. A plausible mechanism invoking a [3+2]‐spiro‐ annulation reaction and quenching the intermediate with proton is explained. Formation of regioselective products from unsymmetrical arynes is explained based on reactivity profiles of arynes/heteroarynes. Synthetic utility of synthesized compounds have been demonstrated.
Ready Access to 3‐Substituted Quinoxalin‐2‐ones under Superparamagnetic Nanoparticle Catalysis
Authors: Nguyen Oanh T. K. , Phan Anh L. T. , Phan Phuong T. , Nguyen Viet D. , Truong Thanh , Le Nhan T. H. , Le Dung T. , Phan Nam T. S. 
Published: January 2018

AbstractFe2O3 superparamagnetic nanoparticles emerged as a productive recyclable heterogeneous catalyst for the cyclization reaction between α‐keto acids and benzene‐1,2‐diamines to produce quinoxalinones as major products and benzimidazoles as minor products. The Fe2O3 nanoparticles displayed higher activity in the synthesis of quinoxalinones than a series of nano catalysts as well as iron‐, copper‐, nickel‐, and cobalt‐based homogeneous catalysts. Moreover, the Fe2O3 nanoparticles was easily recovered by magnetic decantation, and was reutilized without a remarkable deterioration in catalytic activity and selectivity towards quinoxalinones. To our best knowledge, this transformation was not previously conducted under heterogeneous catalysis conditions.
Cognitive flexibility and adaptive decision‐making: Evidence from a laboratory study of expert decision makers
Authors: Laureiro‐Martínez Daniella , Brusoni Stefano 
Published: January 2018

Research Summary: How can strategic decision makers overcome inertia when dealing with change? In this article we argue that cognitive flexibility (i.e., the ability to match the type of cognitive processing with the type of problem at hand) enables decision makers to achieve significantly higher decision‐making performance. We show that superior decision‐making performance is associated with using semiautomatic Type 1 cognitive processes when faced with well‐structured problems, and more deliberative Type 2 processes when faced with ill‐structured problems. Our findings shed light on the individual‐level mechanism behind organizational adaptation and complement recent work on strategic inertia. In addition, our findings extend management studies that have stressed the relevance of cognitive flexibility for responding to the demands of increasingly open, flexible, and rapidly changing organizations.Managerial Summary: Humans are creatures of habits. We tend to prefer known courses of action over new ones. In many cases, habits are good. However, when things change in unpredictable ways, the past may not be good guidance for the future. We argue that “cognitive flexibility”—the ability of understanding when to rely on habits vs. when to explore new courses of action—enables managers to switch from a “fast” decision mode, based on habits, to a “slow,” more deliberate decision mode that facilitates the exploration of new courses of action. Managers high in cognitive flexibility reflect on the situation at hand, recognize and value diversity in viewpoints, and integrate such diversity in their own decision processes. By valuing diversity, they are more likely to overcome inertia.
The Role of Corporate Taxation in a Large Welfare State
Authors: Keuschnigg Christian 
Published: January 2018

Summary
In comparing the impact of corporate taxation and social insurance on foreign direct investment (FDI) and unemployment, the paper derives four main results: (i) the optimal size of the welfare state depends on the degree of risk-aversion, the unemployment rate and the excess burden of labor taxes. Unemployment partly reflects the country’s exposure to globalization; (ii) corporate taxation and social insurance can have equivalent effects on unemployment and outbound FDI; (iii) while an increase in the corporate tax raises corporate tax revenue, it is likely to worsen total fiscal stance; (iv) a corporate tax should be used to contribute to welfare state financing only in exceptional cases.
Migration and trade union rights
Authors: Baudassé Thierry , Bazillier Rémi 
Published: January 2018

Summary
We study in this paper both theoretically and empirically the influence of trade union rights in origin countries on bilateral migration flows. Theoretically, trade union rights are supposed to increase the bargaining power of workers. Alternatively, it may benefit only to formal workers if these rights are not applied in the informal sector. We then propose different alternative indexes measuring trade union rights. We find that, all things being equal, more trade union rights tend to be associated with less migration of low-skill and high-skilled workers. Effects are not significant for intermediate skill level. Lastly, we show that social tensions may have the opposite effect. If trade union rights are associated with more social instability, it may increase the level of migration. It emphasizes the importance of social dialogue.