bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining hotel characteristics and facilities influencing customer satisfaction using decision tree analysis
Authors: Pişirgen Ali , Erdoğan Ali Mert , Peker Serhat 
Published: September 2024

Purpose
This study aims to identify the key hotel characteristics and facilities that significantly influence customer satisfaction based on Google review scores. By applying decision tree analysis, the research seeks to determine which aspects, such as service quality, hotel facilities and location, play pivotal roles in shaping customer experiences. The objective is to provide professional with practical recommendations to improve service quality and cultivate enduring customer loyalty.

Design/methodology/approach
The research used a data set collected from Hotels.com, featuring various characteristics of 802 hotels in Izmir Province. Decision tree analysis was conducted using Classification and Regression Tree algorithm to explore the relationship between hotel characteristics and facilities with customer satisfaction.

Findings
The analysis revealed that the number of rooms is the primary factor influencing hotel ratings, with proximity to the airport and hotel classification also being significant. Additional factors such as public transportation distance and laundry services were important, while facilities such as ATMs, beach access and spas showed no significant impact on customer satisfaction. These findings emphasize the importance of core facilities and accessibility.

Originality/value
This study contributes to the literature by offering a novel approach, using decision tree analysis to assess hotel customer satisfaction with structured data. It provides practical implications for hotel managers, enabling them to make data-driven improvements to achieve customer satisfaction. The integration rules created by the decision tree model into hotel management systems can enhance operational efficiency and competitive advantage in the hospitality industry.
Exploring metaverse: affordances and risks for potential users
Authors: Bao Xueqi , Yu Jie , Shou Minghuan 
Published: September 2024

PurposeThis article aims to develop and validate a theoretical model via survey data to identify the affordances and challenges influencing metaverse adoption. We specifically examine the impact of immersion on users' adoption decisions and identify which affordances predict this immersion. Additionally, this paper assesses the importance of perceived risks in users' decision-making processes regarding future metaverse engagement.Design/methodology/approachUsing regression models applied to 198 survey responses, we tested our proposed model. To deepen our insights, we also conducted a qualitative analysis.FindingsThe findings confirm that users' perceptions of immersion and perceived risks are critical determinants in adoption decisions. Social presence, influenced by factors such as ubiquity and interoperability, emerges as a key component of immersion. From the qualitative data, we identified two potential strategies to enhance metaverse immersion: technical improvements and offline device-assisted strategies.Originality/valueOur study contributes to the literature on information systems (IS) adoption and provides practical insights for practitioners on crucial considerations in metaverse design.
Financial instruments with characteristics of equity: outcomes and value relevance
Authors: Flores Eduardo , Fasan Marco 
Published: September 2024

Purpose
This study aims to investigate the motivations behind the issuance of financial instruments with characteristics of equity (FICE), economic consequences associated with their issuance and accounting classifications based on a value-relevance approach.

Design/methodology/approach
Using a sample of 169 financial and nonfinancial firms from 10 jurisdictions that adopted International Financial Reporting Standards, the authors use a difference-in-differences econometric approach.

Findings
The findings reveal that FICE issuers are more leveraged companies with higher costs of equity and, in some cases, lower effective tax rates. This evidence corroborates the hypothesis that issuers of FICEs seek to increase their book values of equity (accounting treatment as equity) and, simultaneously, generate deductible expenses for tax purposes (tax treatment as liability).

Practical implications
This finding suggests that market participants do not treat these instruments as regular equity but rather as quasi-equity. The findings suggest that a binary classification of FICE as debt or equity may not be the accounting treatment that best represents the underlying economic substance of these contracts. Furthermore, this study reinforces the IASB indication regarding to increase the FICE disclosure to allow stakeholders to better understand the economic essence of these bonds.

Originality/value
This study assesses the economic outcomes and market evaluation of a specific type of FICE that has not been previously studied, which is similar to the examples provided by the IASB in their materials on the subject.
Corporate governance and firm performance: in Qatari non-financial firms
Authors: Al-Shaer Basel , Aldboush Hassan H.H. , H. Alnajjar Ahmad Hisham 
Published: September 2024

Purpose
This paper aims to examine the relationship between corporate governance mechanisms and firm performance in Qatari non-financial firms over a nine-year period, including the period of high uncertainty caused by the COVID-19 pandemic.

Design/methodology/approach
The study uses data from Refinitiv and employs panel data econometric techniques, namely generalized least squares (GLS), to analyze the impact of board characteristics (board size, board meetings, board gender diversity, board-specific skills, board independence), audit committee features (existence of audit committee, audit committee independence), CEO duality and management scores on both accounting and market performance of Qatari firms. Control variables include firm size, age, leverage and industry classifications.

Findings
The findings suggest that board-specific skills positively influence firm performance, while board size and gender diversity exhibit a non-significant impact. Audit committee independence enhances accounting performance but does not significantly affect market performance. Surprisingly, management scores show a significant yet negative impact on certain financial measures, indicating the need for further investigation.

Practical implications
These insights provide valuable guidance for policymakers, investors and corporate leaders, emphasizing the importance of tailored governance practices in Qatar's unique business landscape.

Originality/value
This study provides unique insights into the governance-performance relationship in the context of Qatar, a region with limited existing research. The inclusion of the COVID-19 period adds a contemporary dimension to the analysis, highlighting the resilience and adaptability of corporate governance practices during times of crisis.
The cascading role of leader-induced defensive cognitions and citizenship pressures in navigating employee silence
Authors: Tahir Muhammad Zohaib , Awan Tahir Mumtaz , Mughal Farooq , Waheed Aamer 
Published: September 2024

Purpose
The study aims to attain insights into the impact of destructive leadership and citizenship pressures in inducing employee silence through the lens of social exchange and the conservation of resources theory. The research further relies on Friedkin’s attitude-behaviour linkage framework (2010), while taking into account the role of employees’ defensive cognitive evaluations, as against the previously accented emotion-focused explanations.

Design/methodology/approach
In order to corroborate the pertinence and contextual relevance of the framework, a survey-based study was conducted with a purposively selected sample of 133 full-time employees from the systemically important banks. The sample size was determined through an a-priori power analysis using G*Power, and the hypothesized serial mediation model was tested using PLS-SEM in SmartPLS v_4.0.

Findings
The findings accentuate the significance of destructive leadership in navigating employees’ silence directly and serially through continuance commitment and compulsory citizenship behaviours. The study also underlines that rather than being portrayed as unidimensional outcomes centered on attitudes, employee behaviours ought to be considered contingent retorts under attitude-behaviour cascades.

Originality/value
The study contributes to strategic human resource management literature by offering a cognition-based explanation for employees’ silence, taking Pakistan’s cultural and contextual orientation into cognizance. Extending on the attitude-behaviour linkage framework, the study provides that attitudes shaped by defensive cognitive evaluations may concurrently foster involuntary (citizenship) as well as voluntary (silence) behaviours.
Preventing Postpartum Venous Thromboembolism With Low‐Molecular‐Weight Heparin: The PP‐HEP Pilot Randomised Controlled Trial
Authors: Blondon Marc , Claver Marine , Celetta Emilienne , Righini Marc , de Tejada Begoña Martinez 
Published: September 2024

ABSTRACTObjectiveUncertainty surrounds the risk–benefit of low‐molecular‐weight heparin to prevent postpartum venous thromboembolism (VTE). Data from randomised clinical trials (RCT) are critically needed, but recent feasibility studies in North America yielded low participation rates, with <1 enrolment per month per centre. Our aim was to assess the feasibility of a trial of postpartum short‐term enoxaparin in Europe.DesignPragmatic, open‐label pilot randomised controlled trial (RCT).SettingSwiss tertiary hospital.PopulationPostpartum women, within 48 h of delivery, deemed at intermediate risk of VTE with at least one major risk factor (morbid obesity, thrombophilia, emergency caesarean section, pre‐eclampsia, preterm delivery, intrauterine growth restriction or systemic peripartum infection) and/or at least two minor risk factors.MethodsParticipants were randomised to enoxaparin 40–60 mg once daily for 10 days or no treatment, with a 90‐day follow‐up.Main Outcome MeasuresParticipation rate and study acceptance (randomised participants among women in whom informed consent was sought).ResultsRecruitment was open for 25 weeks in 2022. Among 1504 postpartum women, 480 were eligible and 77 were randomised. The recruitment rate was 3.1 per week (13.3 per month) and the study acceptance was 23.8%. At 3 months, there was no VTE event, but one major, one nonmajor obstetrical bleeding and one surgical site complication, all in the enoxaparin group.ConclusionsThis pilot RCT of postpartum thromboprophylaxis set in Switzerland yielded greater participation rate and acceptance than previous attempts in North America. It calls for a large, international, collaborative trial to guide this important clinical decision.Trial RegistrationClinicalTrial.gov identifier: NCT05878899 and NCT04153760.
The Mycobacterium tuberculosis Cell Wall: An Alluring Drug Target for Developing Newer Anti‐TB Drugs—A Perspective
Authors: Chauhan Monica , Barot Rahul , Yadav Rasana , Joshi Karan , Mirza Sadaf , Chikhale Rupesh , Srivastava Vijay Kumar , Yadav Mange Ram , Murumkar Prashant R. 
Published: September 2024

ABSTRACTThe Mycobacterium cell wall is a capsule‐like structure comprising of various layers of biomolecules such as mycolic acid, peptidoglycans, and arabinogalactans, which provide the Mycobacteria a sort of cellular shield. Drugs like isoniazid, ethambutol, cycloserine, delamanid, and pretomanid inhibit cell wall synthesis by inhibiting one or the other enzymes involved in cell wall synthesis. Many enzymes present across these layers serve as potential targets for the design and development of newer anti‐TB drugs. Some of these targets are currently being exploited as the most druggable targets like DprE1, InhA, and MmpL3. Many of the anti‐TB agents present in clinical trials inhibit cell wall synthesis. The present article covers a systematic perspective of developing cell wall inhibitors targeting various enzymes involved in cell wall biosynthesis as potential drug candidates for treating Mtb infection.
Compound heterozygosity for two variants in BMP5 in human skeletal dysostosis with atrioventricular septal defect
Authors: Gregersen Pernille Axél , Hammarsjö Anna , Graversen Lise , Brix Nis , Lindelöf Hillevi , Jensen Uffe Birk , Farholt Stense , Rubak Sune , Bjerre Jesper , Piticchio Serena G. , Terkelsen Thorkild , Nishimura Gen , Hellfritzsch Michel Bach , Grigelioniene Giedre 
Published: September 2024

AbstractThe growth and development of the skeleton is regulated by bone morphogenetic proteins of which several are linked to genetic skeletal disorders. So far, no human skeletal malformations have been associated with variants in BMP5. Here, we report a patient with biallelic loss of function variants in BMP5 and a syndromic phenotype including skeletal dysostosis, dysmorphic features, hypermobility, laryngo‐tracheo‐bronchomalacia and atrioventricular septal defect. We discuss the phenotype in relation to the known tissue‐specific expression of Bmp5 and similar morphological abnormalities previously reported in experimental animal models. Our findings suggest a new association between BMP5 variants and a range of developmental anomalies, involving ears, heart and skeleton, thereby increasing understanding of BMP5's role in human development.
Betulin ameliorates neuronal apoptosis and oxidative injury via DJ‐1/Akt/Nrf2 signaling pathway after subarachnoid hemorrhage
Authors: Lu Xiaoyang , Yang Shu , Lu Qixiong , Zhang Yuansheng , Cha Zaihong , Huang Wei , Li Tao 
Published: September 2024

AbstractAimsWe aimed to resolve the uncertainty as to whether betulin exerted neuroprotection on early brain injury (EBI) caused by subarachnoid hemorrhage (SAH), and to investigate the related molecular mechanisms.MethodsBioinformatic analysis was performed to pre‐study the differently expressed genes (DEGs) and the possible signaling pathways. Rat and cellular model of SAH were introduced in this study, and betulin, an activator of DJ‐1 protein, was administered to reveal the effect. Gross assessment regarding mortality, neurofunctions, SAH grade, brain water content (BWC) along with multiple cellular and molecular studies in vivo or/and in vitro such as immunofluorescence (IF) staining, western blot (WB), reactive oxygen species (ROS) assay, and flow cytometry (FCM) were all conducted after SAH induction to verify the protective effect and the relevant mechanisms of DJ‐1 in diverse levels. In addition, MK2206 (selective inhibitor of Akt) and iRNADj‐1 (interfering RNA to Dj‐1) were utilized to confirm the mechanisms of the effect.ResultsThe data from our study showed that DJ‐1 protein was moderately expressed in neurons, microglia, and astrocytes; its level in brain tissue elevated and peaked at 24–72 h after SAH induction. Betulin could efficaciously induce the expression of DJ‐1 which in turn activated Akt and Bcl‐2, and anti‐oxidative enzymes SOD2 and HO‐1, functioning to reduce the activation of cleaved caspase‐3 (c‐Casp‐3) and reactive oxygen species (ROS). The induced DJ‐1 could upregulate the expression of Nrf2. However, Akt seemed no direct effect on elevating the expression of Nrf2. DJ‐1 alone could as well activate Akt‐independent antiapoptotic pathway via suppressing the activation of caspase‐8 (Casp‐8).ConclusionsBetulin which was a potent agonist of DJ‐1 had the ability to induce its expression in brain tissue. DJ‐1 had neuroprotective effect on EBI through comprehensive mechanisms, including facilitating intrinsic and extrinsic antiapoptotic pathway, and reducing oxidative injury by upregulating the expression of redox proteins. Betulin as an inexpensive drug showed the potential for SAH treatment.
The concurrent validity of a portable ultrasound probe for muscle thickness measurements
Authors: Homer Kai A. , Cross Matt R. , Jukic Ivan 
Published: September 2024

AbstractUltrasound imaging is extensively used by both practitioners and researchers in assessing muscle thickness (MT); however, its use in the field is constrained by the transportability of stationary devices. New portable ultrasound probes pose as a cost‐effective and transportable alternative for field‐based assessments. This study evaluated the concurrent validity of a portable probe (Lumify) against a laboratory‐based device (Vivid S5) in measuring MT. Eighteen participants (nine males and nine females) visited the laboratory and their MT measurements were collected using each device at five different sites (anterior and posterior arm, anterior and posterior thigh, and posterior lower leg). Bland‐Altman plots (systematic and proportional bias, random error, and 95% limits of agreement), Pearson's product–moment correlation coefficient (r), and paired samples t‐tests with Cohen's d effect sizes (ES) were used to assess the concurrent validity of the Lumify device. Systematic bias was low at all sites ( ≤ 0.11 cm) while proportional bias was detected only at the posterior lower leg (r2 = 0.217 [r = 0.466]). The difference in MT between devices was significant only at the anterior thigh (p < 0.05); however, ES for all sites were considered trivial (ES ≤ 0.131). Linear associations were found between the devices at each site of measurement (r ≥ 0.95). These results highlight that the Lumify probe can be used interchangeably with the Vivid S5 for MT measurements, providing practitioners and researchers with a more cost‐effective and portable alternative for field‐based assessments.
The endless reform process: Realities behind Jordan's political modernization efforts
Authors: Salameh Mohammed Torki Bani , Alakayleh Moath , Emambocus Washad 
Published: September 2024

AbstractThe latest royal committee headed by Samir Al‐Rifai to modernize Jordan's political system is often portrayed as a significant step toward political reform. However, this narrative overestimates the committee's impact and overlooks historical limitations and institutional obstacles to reform in Jordan. This study highlights how political reform initiatives in Jordan can be manipulated to serve the regime's objectives rather than the people's will. Historically, despite public pressure for genuine political reform, the regime's responses have been minimal. Royal committees and initiatives have rarely produced tangible results, serving more to provide the regime with narratives of superficial reform than to achieve real change.
A New Strategy for Adult T‐Cell Leukemia Treatment Targeting Glycogen Synthase Kinase‐3β
Authors: Ishikawa Chie , Mori Naoki 
Published: September 2024

ABSTRACTObjectivesThe role of glycogen synthase kinase (GSK)‐3β in adult T‐cell leukemia (ATL) caused by human T‐cell leukemia virus type 1 (HTLV‐1) is paradoxical and enigmatic. Here, we investigated the role of GSK‐3β and its potential as a therapeutic target for ATL.MethodsCell proliferation/survival, cell cycle, apoptosis, and reactive oxygen species (ROS) generation were examined using the WST‐8 assay, flow cytometry, and Hoechst 33342 staining, respectively. Expression of GSK‐3β and cell cycle/death‐related proteins, and survival signals was analyzed using RT‐PCR, immunofluorescence staining, and immunoblotting.ResultsHTLV‐1‐infected T‐cell lines showed nuclear accumulation of GSK‐3β. GSK‐3β knockdown and its inhibition with 9‐ING‐41 and LY2090314 suppressed cell proliferation/survival. 9‐ING‐41 induced G2/M arrest by enhancing the expression of γH2AX, p53, p21, and p27, and suppressing the expression of CDK1, cyclin A/B, and c‐Myc. It induced caspase‐mediated apoptosis by decreasing the expression of Bcl‐xL, Mcl‐1, XIAP, c‐IAP1/2, and survivin, and increasing the expression of Bak and Bax. 9‐ING‐41 also induced ferroptosis and necroptosis, promoted JNK phosphorylation, and suppressed IKKγ and JunB expression. It inhibited the phosphorylation of IκBα, Akt, and STAT3/5, induced ROS production, and reduced glycolysis‐derived lactate levels.ConclusionGSK‐3β functions as an oncogene in ATL and could be a potential therapeutic target.
Real‐world effectiveness and safety of switching to dolutegravir/lamivudine among people living with HIV‐1 aged over 50 years who are virologically suppressed
Authors: Piñeiro C. , Policarpo S. , Caldas C. , Santos L. , Augusto I. , DiMondi V. P. , Serrão R. 
Published: September 2024

AbstractObjectivesPeople living with HIV face several challenges as they age, including the potential for polypharmacy and increased susceptibility to drug‐related adverse effects. Thus, effective and well‐tolerated regimens with minimal or no drug interactions would be useful in this population. We present real‐world effectiveness and safety data for individuals aged >50 years who achieved virological suppression (HIV‐1 RNA <50 copies/mL) and switched to dolutegravir/lamivudine (DTG/3TC).MethodsThis retrospective, observational, single‐centre study conducted in Portugal included individuals aged >50 years who switched to DTG/3TC while virologically suppressed and had ≥12 months of follow‐up. Proportions of individuals maintaining virological suppression were described at 12 months; CD4+ cell counts were described at baseline and 12 months. Descriptive subgroup analyses were performed based on age, sex assigned at birth, and availability of historical genotypic resistance results.ResultsOverall, 538 individuals aged >50 years were included (74% male; mean age, 62 years; mean time on previous therapy, 160 months). High proportions (intention‐to‐treat population, 97%; on‐treatment population, 98%) of individuals who switched to DTG/3TC maintained virological suppression through 12 months of follow‐up. CD4+ cell counts remained stable (mean baseline: 727 cells/mm3 [range 94–2371]; mean month 12: 742 cells/mm3 [range 99–2659]). No individuals experienced virological failure. Nine (2%) individuals discontinued DTG/3TC for non–treatment‐related reasons. Proportions with virological suppression at month 12 were similar between on‐treatment subgroups by age, sex assigned at birth, and historical genotypic resistance results availability.ConclusionsDTG/3TC demonstrated robust effectiveness and a good safety profile in individuals aged >50 years with virological suppression in Portugal.
The use of herbs and spices in fish preservation at chilled temperature storage: opportunities and challenges
Authors: Parmar Bhaviksinh K. , Mohite Ashish S. , Pathan Dabir I. , Desai A. S. , Wasave Suhas M. 
Published: September 2024

SummaryFish can justify a healthy human diet. Spoilage is caused due to microbial degradation and oxidative rancidity. Herbs and spices (H&S) are common ingredients in fish marination to improve quality and appeal to consumers globally. The given review delves into the potential of H&S to extend the freshness of fish while also addressing challenges in maximising their effectiveness for preservation and proposing innovative solutions. H&S with antimicrobial (AM) and antioxidative (AO) effects reduce biogenic amine (BA) formation by inhibiting the decarboxylation of free amino acids through microbial reduction and retarding lipid oxidation of free fatty acids by countering free radicals. Combining organoleptically standardised H&S with diverse microbial hurdle techniques supports extensive domestic utilisation, extending the shelf life of fish significantly compared to using them alone. The present findings recommend that H&S can maintain fish quality for 6–20 days, depending on the fish species, packaging, and AO/AM potential in refrigeration conditions. Thyme, garlic, ginger, stevia, turmeric, laurel, sage, cinnamon, cumin, mint, and rosemary are found to be the most potent preservatives that could be utilised commercially to increase fish's shelf life. Variations in H&S extracts and fish muscle composition pose challenges in optimising the effectiveness of bioactive compounds in fish preservation. Innovative approaches for utilising H&S essential oils (EOs) and advanced delivery techniques offer solutions to these challenges, leading to improved fish quality and limited shelf life.