bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brief Report: Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis
Authors: van den Bosch Martijn H. , Blom Arjen B. , van de Loo Fons A. , Koenders Marije I. , Lafeber Floris P. , van den Berg Wim B. , van der Kraan Peter M. , van Lent Peter L. 
Published: July 2017

ObjectiveIncreased Wnt signaling in chondrocytes is associated with development of osteoarthritis (OA). However, OA is considered a disease of the entire joint, where the synovium has been attributed an important role in disease pathogenesis and progression. This study was undertaken to determine whether Wnt signaling in synovial tissue could contribute to pathologic development of OA through the production of matrix metalloproteinases (MMPs), and to assess the relationship of synovial expression of Frizzled (FZD) receptors and the Wnt inhibitor FRZB to MMP expression and disease progression in patients with early OA in the Dutch Cohort Hip and Cohort Knee (CHECK) study cohort.MethodsIn mouse knee joints, human WNT8A and mouse Wnt16 were overexpressed using adenoviral vectors, and expression of messenger RNA (mRNA) for MMPs in the synovium was determined by reverse transcription–polymerase chain reaction or Luminex assay. In human synovial tissue from a subgroup of patients with early OA with knee pain enrolled in the CHECK cohort, levels of Wnt family members were assessed for linkage to MMP expression and disease progression. In addition, MMP production in human synovium from patients with end‐stage OA was determined after stimulation of Wnt signaling with WNT3A or inhibition with FRZB or DKK1 in the synovium.ResultsOverexpression of WNT8A and Wnt16 in mouse knee joints induced MMP expression in vivo. Expression of MMPs relevant to human OA in the synovium from CHECK study participants significantly correlated with expression of FZD1, FZD10, and FRZB mRNA. Moreover, increased FZD1 mRNA expression and decreased FRZB mRNA expression were observed in CHECK study patients who experienced disease progression compared to those who were nonprogressors. Stimulation of human OA synovium with WNT3A induced the production of various MMPs, whereas inhibition of Wnt signaling with FRZB or DKK1 reduced the production of MMPs.ConclusionWnt signaling in the synovium may potently induce progression of OA via increased production of MMPs.
Entwurfsplanung der Wolbecker‐Straßenbrücke Nr. 76 über den DEK in Münster
Authors: Engelke Nils , Herbort Johannes 
Published: July 2017

AbstractIm Rahmen des Infrastrukturprojekts „Ausbau des Dortmund‐Ems‐Kanals” innerhalb der Stadtstrecke Münster ist ab 2018 die Wolbecker‐Straßenbrücke Nr. 76 als Ersatzneubau an gleicher Stelle mit vergrößerter Stützweite neu zu errichten. Die neue Straßenbrücke wird als anspruchsvoll gestaltete vollstählerne Stabbogenbrücke mit einer Stützweite von 67,20 m ausgeführt. Bei der Gestaltung des Brückenbauwerks wurde unter Einbeziehung der Unterbauten, der Nebenanlagen, der Farbgebung und eines Illuminationskonzepts ein ganzheitlicher Ansatz gewählt. In Teilen der Gründungskonstruktion werden bestehende Pfeilerelemente in den Neubau der Widerlager bzw. Tiefgründung integriert. Da das Bauvorhaben im innerstädtischen Bereich neben direkter Wohnbebauung liegt, gelten unter anderem strenge Auflagen hinsichtlich des Lärmschutzes im Zuge der Bauausführung. In Vorbereitung auf die bevorstehende Ausschreibung und Vergabe des Bauauftrags in 2018 erläutert der vorliegende Aufsatz die wesentlichen Aspekte der Vorentwurfs‐ und Entwurfsplanung des Ersatzneubaus der Wolbecker‐Straßenbrücke Nr. 76 über den DEK.
CD36 expression in peripheral blood mononuclear cells reflects the onset of atherosclerosis
Authors: Yazgan Burak , Sozen Erdi , Karademir Betul , Ustunsoy Seyfettin , Ince Umit , Zarkovic Neven , Ozer Nesrin Kartal 
Published: July 2017

AbstractTogether with complex genetic and environmental factors, increased serum cholesterol and ox‐LDL levels are considered as major triggering factors of atherosclerosis. Mononuclear cell infiltration to the arterial wall and uptake of ox‐LDL, which is facilitated by CD36 receptor through an uncontrolled manner, play a key role in foam cell formation followed by atherogenesis development. The aim of this study was to analyze if CD36 expression in peripheral blood mononuclear cells reflect its aortic tissue level in hypercholesterolemia. In this study, CD36 protein expression was evaluated in aortic specimens of cholesterol or cholesterol plus Vitamin E treated animals in relation to the immunohistochemical analyses for the HNE‐protein adducts, as well as for smooth muscle actin and vimentin. The CD36 mRNA expression was determined by RT‐PCR in PBMC of hypercholesterolemic rabbits and hypercholesterolemic versus normocholesterolemic individuals. Immunohistochemistry findings revealed that smooth muscle actin, smooth muscle vimentin, HNE‐protein conjugates, and CD36 protein expressions were significantly increased in aorta of hypercholesterolemic group where foam cells were present. High cholesterol diet significantly induced CD36 mRNA expression in both rabbit aorta and PBMCs, while positive correlation between aortic and PBMC CD36 expression has been found. In addition, consistent with the rabbit model, CD36 mRNA expression levels in human PBMCs were significantly higher in hypercholesterolemic patients than in normocholesterolemic individuals. Taken together, these results demonstrate that the CD36 mRNA levels of PBMCs could reflect the CD36 mRNA levels in aorta and could be used as a biomarker for diagnosis of atherosclerotic burden. © 2018 BioFactors, 44(6):588–596, 2018
Assessment of Physical Child Abuse Risk in Parents with Children Referred to Child and Adolescent Psychiatry
Authors: Van Looveren Natalie , Glazemakers Inge , Van Grootel Linda , Fransen Erik , Van West Dirk 
Published: July 2017

Given the vulnerability of the child psychiatric population, this study examined whether parenting a child referred to a child and adolescent psychiatry department leads to a higher risk of physical child abuse and if that risk is associated with a specific child psychopathology. The clinical sample consisted of caregivers with a six‐to‐11‐year‐old child who consulted child and adolescent psychiatry for a psychiatric assessment. The Dutch Child Abuse Potential Inventory (CAPI), socio‐demographic data and child psychiatric diagnosis were collected from 59 caregivers of 59 children. Ten per cent of the sample obtained an Abuse scale score indicative of a potential risk for physically maltreating their child. Compared to a non‐clinical sample, this study showed a two and a half times higher risk potential for physical child abuse in caregivers with children referred to child and adolescent psychiatry. The elevated risk was not associated with a specific child psychiatric diagnosis. The caregivers at risk were more unhappy and experienced more problems with their child, their family and with others. Results support the need for implementing a standard risk assessment for physical child abuse in a child psychiatric setting. Copyright © 2017 John Wiley & Sons, Ltd.‘This study examined whether parenting a child referred to a child and adolescent psychiatry department leads to a higher risk of physical child abuse’Key Practitioner Messages

Compared to a non‐clinical sample, there is a two and a half times higher risk potential for physical child abuse in caregivers with children with mental health problems examined with the self‐report screening questionnaire CAPI.
Child psychopathology in general is associated with an elevated potential for physical child abuse; there is no correlation with a specific child psychiatric disorder.
There is a need for implementing a standard risk assessment for child abuse in a clinical child psychiatric setting.
Direct Hydrogenation of a Broad Range of Amides under Base‐free Conditions using an Efficient and Selective Ruthenium(II) Pincer Catalyst
Authors: Wang Zheng , Li Yong , Liu Qing‐bin , Solan Gregory A. , Ma Yanping , Sun Wen‐Hua 
Published: July 2017

AbstractThe ruthenium(II) complex, [fac‐PNHN]RuH(η1‐BH4)(CO) (B; PNHN=8‐(2‐diphenylphosphinoethyl)aminotrihydroquinoline), is a highly versatile and effective catalyst (loadings of 0.1–1 mol %) for the hydrogenation of a multitude of amides, which include primary, secondary, and tertiary amides, to give their corresponding alcohols and amines in high yields under base‐free conditions. All products were confirmed by using GC and GC–MS.
Ni–Co Binary Hydroxide Nanotubes with Three‐Dimensionally Structured Nanoflakes: Synthesis and Application as Cathode Materials for Hybrid Supercapacitors
Authors: Dai Ziyang , Lin Jianjian , Dong Qiuchun , Yin Zhihui , Zang Xiaoxian , Shen Lei , Kim Jung Ho , Huang Wei , Alshehri Saad M. , Young Christine , Yamauchi Yusuke , Dong Xiaochen 
Published: July 2017

AbstractNickel–cobalt binary hydroxide nanotubes were fabricated by a facile synthetic approach by using Cu2O nanowires as sacrificial templates. The surface morphology of the binary hydroxide nanotubes can be easily controlled by adjusting the molar ratio of Ni to Co. With increasing Co content, the surfaces of the nanotubes tend to form hierarchical nanoflakes. The obtained nanotubes with high specific surface area exhibit typical battery‐like electrochemical behavior. Among them, Ni–Co hydroxide nanotubes with Ni:Co=48:52 showed outstanding electrochemical characteristics, with a specific capacity of 209.9 mAh g−1 at 1 Ag−1 and remarkable cycling stability with 84.4 % capacity retention after 10 000 cycles at 20 A g−1. With the advantages of their unique nanostructure and the synergistic effect of the two elements, the Ni–Co binary hydroxide nanotubes are expected to be effective potential cathode materials for hybrid supercapacitors.
DFT‐Supported Threshold Ionization Study of Chromium Biphenyl Complexes: Unveiling the Mechanisms of Substituent Influence on Redox Properties of Sandwich Compounds
Authors: Ketkov Sergey Yu. , Tzeng Sheng‐Yuan , Wu Pei‐Ying , Markin Gennady V. , Tzeng Wen‐Bih 
Published: July 2017

AbstractHigh‐resolution mass‐analyzed threshold ionization (MATI) spectra of (η6‐Ph2)2Cr and (η6‐Ph2)(η6‐PhMe)Cr demonstrate that the Ph groups work as electron donors, decreasing the ionization energy of the gas‐phase bisarene complexes. In contrast to electrochemical data, a close similarity of the Ph and Me group effects on the oxidation of free sandwich molecules has been revealed. However, DFT calculations testify for the opposite shifts of the electron density caused by the Me and Ph substituents in the neutral complexes, the latter behaving as an electron‐accepting fragment. On the contrary, in the bisarene cations, the Ph group becomes a stronger donor than methyl. This change provides the similar substituent effects observed with the MATI experiment. On the other hand, the well‐documented opposite influence of the Me and Ph fragments on the redox potential of the (η6‐arene)2Cr+/0couple in solution appears to be a result of solvation effects but not intramolecular interactions as shown for the first time in this work.
Energy Efficient Synthesis of Ordered Mesoporous Carbon Nitrides with a High Nitrogen Content and Enhanced CO2 Capture Capacity
Authors: Park Dae‐Hwan , Lakhi Kripal S. , Ramadass Kavitha , Kim Min‐Kyu , Talapaneni Siddulu N. , Joseph Stalin , Ravon Ugo , Al‐Bahily Khalid , Vinu Ajayan 
Published: July 2017

AbstractHighly ordered mesoporous carbon nitrides (MCN) with 3D structure and a high nitrogen content are successfully prepared for the first time using “uncalcined” mesoporous silica template, KIT‐6 and 3‐amino‐1,2,4‐triazole as a single molecular carbon and nitrogen precursor. The prepared MCN with C and N stoichiometry of C3N5 shows unique CN framework and exhibits the CO2 capture capacity of 5.63 mmol g−1 at 273 K and 30 bar, which is higher than that of MCN with 2D structure and C3N4 stoichiometry.
Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50
Authors: Chandrasekharappa Settara C. , Chinn Steven B. , Donovan Frank X. , Chowdhury Naweed I. , Kamat Aparna , Adeyemo Adebowale A. , Thomas James W. , Vemulapalli Meghana , Hussey Caroline S. , Reid Holly H. , Mullikin James C. , Wei Qingyi , Sturgis Erich M. 
Published: July 2017

BACKGROUNDPatients with Fanconi anemia (FA) have an increased risk for head and neck squamous cell carcinoma (HNSCC). The authors sought to determine the prevalence of undiagnosed FA and FA carriers among patients with HNSCC as well as an age cutoff for FA genetic screening.METHODSGermline DNA samples from 417 patients with HNSCC aged <50 years were screened for sequence variants by targeted next‐generation sequencing of the entire length of 16 FA genes.RESULTSThe sequence revealed 194 FA gene variants in 185 patients (44%). The variant spectrum was comprised of 183 nonsynonymous point mutations, 9 indels, 1 large deletion, and 1 synonymous variant that was predicted to effect splicing. One hundred eight patients (26%) had at least 1 rare variant that was predicted to be damaging, and 57 (14%) had at least 1 rare variant that was predicted to be damaging and had been previously reported. Fifteen patients carried 2 rare variants or an X‐linked variant in an FA gene. Overall, an age cutoff for FA screening was not identified among young patients with HNSCC, because there were no significant differences in mutation rates when patients were stratified by age, tumor site, ethnicity, smoking status, or human papillomavirus status. However, an increased burden, or mutation load, of FA gene variants was observed in carriers of the genes FA complementation group D2 (FANCD2), FANCE, and FANCL in the HNSCC patient cohort relative to the 1000 Genomes population.CONCLUSIONSFA germline functional variants offer a novel area of study in HNSCC tumorigenesis. FANCE and FANCL, which are components of the core complex, are known to be responsible for the recruitment and ubiquitination, respectively, of FANCD2, a critical step in the FA DNA repair pathway. In the current cohort, the increased mutation load of FANCD2, FANCE, and FANCL variants among younger patients with HNSCC indicates the importance of the FA pathway in HNSCC. Cancer 2017;123:3943‐54. © 2017 American Cancer Society.
Establishing achievable benchmarks for quality improvement in systemic therapy for early‐stage breast cancer
Authors: Powis Melanie , Sutradhar Rinku , Gonzalez Alejandro , Enright Katherine A. , Taback Nathan A. , Booth Christopher M. , Trudeau Maureen , Krzyzanowska Monika K. 
Published: July 2017

BACKGROUNDSetting realistic targets for performance is a consistent challenge in quality improvement. In the current study, the authors used administrative data to define achievable targets for a panel of 15 previously developed quality indicators (QIs) focusing on systemic therapy in patients with early‐stage breast cancer.METHODSDeterministically linked administrative databases were used to identify patients with TNM stage I to stage III breast cancer who were diagnosed between 2006 and 2010 in Ontario, Canada. For each individual indicator, data‐driven empirical benchmarks were calculated using the pared‐mean benchmark approach. Variation in institution‐level performance for each indicator was examined through the construction of funnel plots.RESULTSA total of 28,303 patients with early‐stage breast cancer were identified, 43% of whom received adjuvant chemotherapy. For the 9 QIs for which receiving the service or outcome was desirable (ie, consultation with a medical oncologist), the benchmark varied from 40.9% to 100%. For the 6 indicators for which not receiving the service or outcome was desirable (ie, incidence of febrile neutropenia), the benchmark varied from 0% to 49.0%. There was substantial variation noted with regard to the number of institutions meeting the target and the amount of interinstitution variation between the QIs. Top performing institutions varied by indicator, with no individual institution meeting the benchmark for all indicators. For the majority of indicators, institution size was not found to be correlated with performance.CONCLUSIONSData‐derived benchmarking can be used to facilitate quality improvement by identifying areas of both good as well as suboptimal performance while defining an achievable target for which to strive. Cancer 2017;123:3772–3780. © 2017 American Cancer Society
A scalable synthetic traffic model of Graph500 for computer networks analysis
Authors: Fuentes Pablo , Benito Mariano , Vallejo Enrique , Bosque José Luis , Beivide Ramón , Anghel Andreea , Rodríguez Germán , Gusat Mitch , Minkenberg Cyriel , Valero Mateo 
Published: July 2017

SummaryThe Graph500 benchmark attempts to steer the design of High‐Performance Computing systems to maximize the performance under memory‐constricted application workloads. A realistic simulation of such benchmarks for architectural research is challenging due to size and detail limitations. By contrast, synthetic traffic workloads constitute one of the least resource‐consuming methods to evaluate the performance. In this work, we provide a simulation tool for network architects that need to evaluate the suitability of their interconnect for BigData applications. Our development is a low computation‐ and memory‐demanding synthetic traffic model that emulates the behavior of the Graph500 communications and is publicly available in an open‐source network simulator. The characterization of network traffic is inferred from a profile of several executions of the benchmark with different input parameters. We verify the validity of the equations in our model against an execution of the benchmark with a different set of parameters. Furthermore, we identify the impact of the node computation capabilities and network characteristics in the execution time of the model in a Dragonfly network.
Automated Computational Processing of 3‐D MR Images of Mouse Brain for Phenotyping of Living Animals
Authors: Medina Christopher S. , Manifold‐Wheeler Brett , Gonzales Aaron , Bearer Elaine L. 
Published: July 2017

AbstractMagnetic resonance (MR) imaging provides a method to obtain anatomical information from the brain in vivo that is not typically available by optical imaging because of this organ's opacity. MR is nondestructive and obtains deep tissue contrast with 100‐µm3 voxel resolution or better. Manganese‐enhanced MRI (MEMRI) may be used to observe axonal transport and localized neural activity in the living rodent and avian brain. Such enhancement enables researchers to investigate differences in functional circuitry or neuronal activity in images of brains of different animals. Moreover, once MR images of a number of animals are aligned into a single matrix, statistical analysis can be done comparing MR intensities between different multi‐animal cohorts comprising individuals from different mouse strains or different transgenic animals, or at different time points after an experimental manipulation. Although preprocessing steps for such comparisons (including skull stripping and alignment) are automated for human imaging, no such automated processing has previously been readily available for mouse or other widely used experimental animals, and most investigators use in‐house custom processing. This protocol describes a stepwise method to perform such preprocessing for mouse. © 2017 by John Wiley & Sons, Inc.
A Guide to Creating and Testing New INTRSECT Constructs
Authors: Fenno Lief E. , Mattis Joanna , Ramakrishnan Charu , Deisseroth Karl 
Published: July 2017

AbstractAs the power of genetically encoded interventional and observational tools for neuroscience expands, the boundaries of experimental design are increasingly defined by limits in selectively expressing these tools in relevant cell types. Single‐recombinase‐dependent expression systems have been widely used as a means to restrict gene expression based on single features by combining recombinase‐dependent viruses with recombinase‐expressing transgenic animals. This protocol details how to create INTRSECT constructs and use multiple recombinases to achieve targeting of a desired gene to subsets of neurons that are defined by multiple genetic and/or topological features. This method includes the design and utilization of both viruses and transgenic animals: these tools are inherently flexible and modular and may be used in different combinations to achieve the desired gene expression pattern. © 2017 by John Wiley & Sons, Inc.
±0.18‐V supply voltage gate‐driven PGA with 0.7‐Hz to 2‐kHz constant bandwidth and 0.15‐μW power dissipation
Authors: Pourashraf Shirin , Ramirez‐Angulo Jaime , Lopez‐Martin Antonio J. , Carvajal Ramon G. , Díaz‐Sánchez Alejandro 
Published: July 2017

SummaryA simple gate‐driven scheme to reduce the minimum supply voltage of AC coupled amplifiers by close to a factor of two is introduced. The inclusion of a floating battery in the feedback loop allows both input terminals of the op‐amp to operate very close to a supply rail. This reduces essentially supply requirements. The scheme is verified experimentally with the example of a PGA that operates with ±0.18‐V supply voltages in 0.18‐μm CMOS technology and a power dissipation of about 0.15 μW. It has a 4‐bit digitally programmable gain and 0.7‐Hz to 2‐kHz true constant bandwidth that is independent on gain with a 25‐pF load capacitor. In addition, simulations of the same circuit in 0.13‐μm CMOS technology show that the proposed scheme allows operation with ±0.08‐V supplies, 7.5‐Hz to 8‐kHz true constant bandwidth with a 25‐pF load capacitor, and a total power dissipation of 0.07 μW.
An improved lightweight multiserver authentication scheme
Authors: Irshad Azeem , Chaudhry Shehzad Ashraf , Kumari Saru , Usman Muhammad , Mahmood Khalid , Faisal Muhammad Shahzad 
Published: July 2017

SummaryMultiserver authentication complies with the up‐to‐date requirements of Internet services and latest applications. The multiserver architecture enables the expedient authentication of subscribers on an insecure channel for the delivery of services. The users rely on a single registration of a trusted third party for the procurement of services from various servers. Recently, Chen and Lee, Moon et al, and Wang et al presented multiserver key agreement schemes that are found to be vulnerable to many attacks according to our analysis. The Chen and Lee scheme was found susceptible to impersonation attack, trace attack, stolen smart card attack exposing session key, key‐compromise impersonation attack, and inefficient password modification. The Moon et al is susceptible to stolen card attack leading to further attacks, ie, identity guessing, key‐compromise impersonation attack, user impersonation attack, and session keys disclosure, while Wang et al is also found to be prone to trace attack, session‐specific temporary information attack, key‐compromise information attack, and privileged insider attack leading to session key disclosure and user impersonation attacks. We propose an improved protocol countering the indicated weaknesses of these schemes in an equivalent cost. Our scheme demonstrates automated and security analysis on the basis of Burrows‐Abadi‐Needham logic and also presents the performance evaluation for related schemes.