bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cement‐based solidification/stabilization of phenol‐contaminated soil by bentonite and organophilic clay
Authors: Heidarzadeh Nima , Jebeli Mojtaba Tayebi , Taslimi Tania 
Published: December 2017

AbstractThe performance of ordinary and organophilic clays in the solidification and stabilization process was investigated with respect to the unconfined compressive strength (UCS) and leaching of phenol‐contaminated soil. The samples contained 2,000 mg/kg of phenol. White cement (15 and 30 percent by weight [wt%]) was used as binder, while ordinary and organophilic clays (8, 15, and 30 wt%) were applied as additives for reducing the harmful effects of phenol interference in cement hydration with a 28‐day curing time. The results revealed that the UCS is reduced by increasing the amount of clays. The values of UCS of all samples met the minimum standards specified for disposal in sanitary landfills determined by developed countries. The leaching test demonstrated that the degree of leaching diminished with increased clay content in all samples of both clay types. This reduction was observed to be greater in samples containing organophilic clay than in bentonite clay samples. Furthermore, the best composition of the materials tested was determined to be 30 wt% white cement plus 13.3 wt% organophilic clay with a compressive strength of 3,839 kPa, phenol removal percentage of 80 percent, and a cost of $67 per ton of contaminated soil.
Detection of unanticipated faults for autonomous underwater vehicles using online topic models
Authors: Raanan Ben‐Yair , Bellingham James , Zhang Yanwu , Kemp Mathieu , Kieft Brian , Singh Hanumant , Girdhar Yogesh 
Published: December 2017

AbstractFor robots to succeed in complex missions, they must be reliable in the face of subsystem failures and environmental challenges. In this paper, we focus on autonomous underwater vehicle (AUV) autonomy as it pertains to self‐perception and health monitoring, and we argue that automatic classification of state‐sensor data represents an important enabling capability. We apply an online Bayesian nonparametric topic modeling technique to AUV sensor data in order to automatically characterize its performance patterns, then demonstrate how in combination with operator‐supplied semantic labels these patterns can be used for fault detection and diagnosis by means of a nearest‐neighbor classifier. The method is evaluated using data collected by the Monterey Bay Aquarium Research Institute's Tethys long‐range AUV in three separate field deployments. Our results show that the proposed method is able to accurately identify and characterize patterns that correspond to various states of the AUV, and classify faults at a high rate of correct detection with a very low false detection rate.
Glutathione levels influence chronological life span of Saccharomyces cerevisiae in a glucose‐dependent manner
Authors: Tello‐Padilla Mayra Fabiola , Perez‐Gonzalez Alejandra Yudid , Canizal‐García Melina , González‐Hernández Juan Carlos , Cortes‐Rojo Christian , Olivares‐Marin Ivanna Karina , Madrigal‐Perez Luis Alberto 
Published: December 2017

AbstractDiet plays a key role in determining the longevity of the organisms since it has been demonstrated that glucose restriction increases life span whereas a high‐glucose diet decreases it. However, the molecular basis of how diet leads to the aging process is currently unknown. We propose that the quantity of glucose that fuels respiration influences reactive oxygen species generation and glutathione levels, and both chemical species impact in the aging process. Herein, we provide evidence that mutation of the gene GSH1 in Saccharomyces cerevisiae diminishes glutathione levels. Moreover, glutathione levels were higher with 0.5% than in 10% glucose in the gsh1Δ and wild‐type strains. Interestingly, the chronological life span was lowered in the gsh1Δ strain cultured with 10% glucose but not under dietary restriction. The gsh1Δ strain also showed inhibition of the mitochondrial respiration in 0.5 and 10% glucose but only increased the H2O2 levels under dietary restriction. These results correlate well with the GSH/GSSG ratio, which showed a decrease in gsh1Δ strain cultured with 0.5% glucose. Together, these data indicate that glutathione exhaustion impact negatively both the electron transport chain function and the chronological life span of yeast, the latter occurring when a low threshold level of this antioxidant is reached, independently of the H2O2 levels.
A New Preoperative Planning Technique Can Reduce Radiation Exposure During the Performance of Medial Opening-Wedge High Tibial Osteotomy
Authors: Spitzer Elad , Ruzbarsky Joseph J. , Doyle John B. , Yin Kaitlyn L. , Marx Robert G. 
Published: December 2017

Background Medial opening-wedge high tibial osteotomy (HTO) is one of the most common and effective HTO techniques, in which the proximal tibia is cut medially, leaving an intact lateral hinge of bone that can be opened to a variable amount for the desired correction, but the technical complications of lateral cortex fracture and intra-articular fracture are well described. The lateral bone hinge for medial opening-wedge HTO is crucial. If the hinge is too small, the tibia can fracture and become unstable, requiring further fixation. If the hinge is too large, the osteotomy can propagate into the joint as an intra-articular fracture when opening the osteotomy. Purpose We propose a new technique that utilizes digital preoperative templating to improve the accuracy of the cut. Preoperative digital templating may allow the surgeon to reproducibly obtain a lateral bone hinge of 10 mm, while also reducing radiation exposure relative to the traditional fluoroscopically assisted technique. Methods Ten cadaver extremities from five cadavers were matched into pairs and randomized into two groups: those with and without preoperative templating. The templating protocol measures the distance between two points on the medial and lateral cortices, and 20 mm is subtracted to determine the depth of the saw cut (10 mm for the hinge and another 10 mm because the proximal tibia is oval in shape). The control method was done by making the cut using fluoroscopy with tactile feedback. Postoperative computed tomography scans were obtained of all legs to measure the width of the lateral bone hinge. Intraoperative fluoroscopy used during both techniques and the numbers of fluoroscopy shots were recorded. Results We found neither the treatment group with preoperative planning nor the control group with the conventional technique had bone hinge widths that were different from the ideal 10 mm. The average hinge widths for the treatment and control groups were 11.2 and 11.5 mm, respectively. However, the treatment group was exposed to significantly less intraoperative fluoroscopy during the osteotomy cut. The average total number of fluoroscopy shots was 2.2 in the treatment group versus 6.3 for the control group. Conclusions This new preoperative planning technique achieves similar accuracy of the lateral bone hinge when compared to current methods but exposes the patient, surgeon, and staff to significantly less intraoperative radiation.
An Alternative Macrophage Activation Pathway Regulator, CHIT1, May Provide a Serum and Synovial Fluid Biomarker of Periprosthetic Osteolysis
Authors: Trehan Samir K. , Zambrana Lester , Jo Jonathan E. , Purdue Ed , Karamitros Athanos , Nguyen Joseph T. , Lane Joseph M. 
Published: December 2017

Background Periprosthetic osteolysis (PPO) is a frequent indication for total hip replacement (THR) failure. Currently, PPO diagnosis occurs in advanced stages that often necessitate complex revisions due to bone loss. PPO biomarkers could facilitate earlier diagnosis. Alternative macrophage activation pathway regulators, chitotriosidase (CHIT1) and CC chemokine ligand 18 (CCL18), have increased periprosthetic expression in patients undergoing revision THR for osteolysis. We hypothesized that synovial fluid and serum levels of CHIT1 and CCL18 would be increased in patients undergoing revision THR for PPO versus controls without osteolysis. Methods In this prospective case-control study, 60 patients undergoing revision metal-on-polyethylene THR at Hospital for Special Surgery were screened preoperatively from January 2013 to December 2014. Twenty “osteolysis” patients who underwent revision for PPO (based on imaging and operative reports) and 10 “control” patients (with stable implants) who underwent revision for recurrent dislocation or a mechanical etiology were included. Among osteolysis and control patients, 11/20 and 4/10 were male; average age was 68 and 63 years, respectively; 9/20 and 3/10 had cemented femoral components; and average implant longevity was 15 and 5 years, respectively. Preoperative serum and intraoperative synovial fluid samples were collected. CHIT1 and CCL18 were quantified via enzyme-linked immunosorbent assay. Significance was assessed via nonparametric Mann-Whiney U test. Results CHIT1 was significantly increased in both synovial fluid (3727 versus 731 nanomoles [nM]) and serum (98 versus 39 nM) in the osteolysis versus control patients. CCL18 levels were also significantly increased in osteolysis versus control patients’ synovial fluid (425 versus 180 nM) but not their serum. Conclusions In this prospective case-control study, CHIT1 was identified as a novel synovial fluid and serum biomarker of PPO. CHIT1 expression is induced during macrophage activation in response to wear debris. CHIT1 monitoring may facilitate early diagnosis of THR PPO. Furthermore, CHIT1 may represent a novel therapeutic target for PPO.
Functional Reach, Depression Scores, and Number of Medications Are Associated With Number of Falls in People With Chronic Stroke
Authors: Alenazi Aqeel M. , Alshehri Mohammed M. , Alothman Shaima , Rucker Jason , Dunning Kari , D'Silva Linda J. , Kluding Patricia M. 
Published: December 2017

AbstractBackgroundFalls are a common adverse event among people with stroke. Previous studies investigating risk of falls after stroke have relied primarily on retrospective fall history ranging from 6‐12 months recall, with inconsistent findings.ObjectivesTo identify factors and balance assessment tools that are associated with number of falls in individuals with chronic stroke.DesignSecondary analysis of a randomized clinical trial.SettingMultisite academic and clinical institutions.ParticipantsData from 181 participants with stroke (age 60.67 ± 11.77 years, post stroke 4.51 ± 4.78 years) were included.MethodsStudy participants completed baseline testing and were prospectively asked about falls. A multivariate negative binomial regression was used to identify baseline predictive factors predicting falls: age, endurance (6 minute walk test), number of medications, motor control (Fugl‐Meyer lower extremity score), depression (Patient Health Questionnaire‐9), physical activity (number of steps per week), and cognition (Mini Mental Status Exam score). A second negative binomial regression analysis was used to identify baseline balance assessment scores predicting falls: gait velocity (comfortable 10 Meter Walk), Berg Balance Scale (BBS), Timed Up and Go (TUG), and Functional Reach Test (FRT). Receiver operating characteristic (ROC) and area under the curve (AUC) were used to determine the cutoff scores for significant predictors of recurrent falls.Main Outcome MeasurementThe number of falls during the 42‐week follow‐up period.ResultsBaseline measures that significantly predicted the number of falls included increased number of medications, higher depression scores, and decreased FRT. Cutoff scores for the number of medications were 8.5 with an AUC of 0.68. Depression scores differentiated recurrent fallers at a threshold of 2.5 scores with an AUC of 0.62. FRT differentiated recurrent fallers at a threshold of 18.15 cm with an AUC of 0.66.ConclusionsNumber of medications, depression scores, and decreased FRT distance at baseline were associated with increased number of falls. Increased medications might indicate multiple comorbidities or polypharmacy effect; increased depression scores may indicate psychological status; and decreased functional reach distance could indicate dynamic balance impairments.Level of EvidenceII
Oral squamous cell carcinoma in a patient with scimitar syndrome
Authors: Sekido Katsuhisa , Tomihara Kei , Fujiwara Kumiko , Tachinami Hidetake , Imaue Shuichi , Noguchi Makoto 
Published: December 2017

AbstractScimitar syndrome is a rare congenital cardiac condition with a poor prognosis. It is frequently accompanied by concordant pulmonary hypoplasia and aortopulmonary collateral arteries connected to the hypoplastic lung. Here we report a case involving a 58‐year‐old woman with scimitar syndrome who developed stage II oral cancer. Surgical treatment was deemed high risk because of difficulty in respiratory management through mechanical ventilation during general anesthesia, and hence, she was treated with chemoradiotherapy, which was successfully completed. The findings from this case suggest that chemoradiotherapy is a useful strategy that can contribute to improved clinical outcomes for oral cancer in patients with scimitar syndrome.
The nature of V2 in Old French: Evidence from subject inversion in embedded clauses
Authors: Zaring Laurie 
Published: December 2017

AbstractOld French (OF) is often characterized as a Germanic-style asymmetric V2 language, although this characterization is often questioned. The present study evaluates the nature of OF V2 from a quantitative perspective. An extensive set of data provided by syntactically annotated corpora shows that both IP and CP structure change over the OF period. Focusing on Germanic inversion – XVS word order – I argue that most of the attested inversion in OF occurs within an elaborated IP structure and that this type of subject inversion dwindles over time due to the decreasing use of null expletives. True Germanic-style embedded V2 does not appear until the late 12thcentury, and is only rarely used throughout the 13thcentury. Thus, OF is an asymmetric V2 language, but with a difference, namely in having an IP field that allows for apparent V2 orders and a CP field that is only marginally employed.
National culture, employee empowerment and advanced manufacturing technology utilisation: A study of Nigeria and New Zealand
Authors: Obi Chris Nwachukwu , Leggett Chris , Harris Howard 
Published: December 2017

AbstractWith manufacturers seeking investment opportunities in Africa, it is timely to explore the interaction of advanced manufacturing technology (AMT) and human resource management approaches there. Because research elsewhere suggests that the effects of the interaction differ across national boundaries, we investigated empowerment approaches and AMT utilisation in Nigeria and New Zealand. Using operational-level survey data from 153 manufacturing managers/CEOs in both countries, we explored the role of national culture on managerial attitudes towards employee empowerment during AMT adoption. Drawing on Hofstede’s cultural dimensions, our results suggest that the observed differences in AMT–empowerment interface are attributable to different national values. The results specifically indicated that during AMT adoption, New Zealand’s liberal culture encourages managers to empower employees more than does Nigeria’s authoritarian one. The results would particularly assist practitioners to recognise the traditional/conservative nature of African values when practicing HR in a country like Nigeria.
Changes in the power balance of institutional logics: Middle managers’ responses
Authors: Olsen Trude Høgvold , Solstad Elsa 
Published: December 2017

AbstractThe purpose of this paper is to explore how middle managers respond when an existing institutional logic is reinforced through radical organisational change. We analyse documents and interviews with middle managers in three public sector contexts (hospitals, upper secondary schools, municipal agencies) in which the power balance between the managerial and professional logics changed through mergers. Contrary to expectations from previous research, we found a variety of responses across contexts. Our data suggest that the middle managers chose whether to acknowledge available information about the managerial logic, and that they either accepted or rejected the new power balance between the logics. There were two different ways of accepting the new power balance: by showing loyalty or through resignation. Its rejection took the form of strategically adhering to the managerial logic as a novice, even though a middle manager was, or should have been, familiar with this logic.
Importance of longwave emissions from adjacent terrain on patterns of tropical glacier melt and recession
Authors: AUBRY-WAKE CAROLINE , ZÉPHIR DORIAN , BARAER MICHEL , McKENZIE JEFFREY M. , MARK BRYAN G. 
Published: December 2017

ABSTRACTTropical glaciers constitute an important source of water for downstream populations. However, our understanding of glacial melt processes is still limited. One observed process that has not yet been quantified for tropical glaciers is the enhanced melt caused by the longwave emission transfer. Here, we use high-resolution surface temperatures obtained from the thermal infrared imagery of the Cuchillacocha Glacier, in the Cordillera Blanca, Peru in June 2014 to calculate a margin longwave flux. This longwave flux, reaching the glacier margin from the adjacent exposed rock, varies between 81 and 120 W m−2 daily. This flux is incorporated into a physically-based melt model to assess the net radiation budget at the modeled glacier margin. The simulation results show an increase in the energy available for melt by an average of 106 W m−2 during the day when compared with the simulation where the LWmargin flux is not accounted for. This value represents an increase in ablation of ~1.7 m at the glacier margin for the duration of the dry season. This study suggests that including the quantification of the glacier margin longwave flux in physically-based melt models results in an improved assessment of tropical glacier energy budget and meltwater generation.
Postoperative symbiotic in patients with head and neck cancer: a double-blind randomised trial
Authors: Lages Priscilla C. , Generoso Simone V. , Correia Maria Isabel T. D. 
Published: December 2017

AbstractStudies on the ‘gut origin of sepsis’ have suggested that stressful insults, such as surgery, can affect intestinal permeability, leading to bacterial translocation. Symbiotics have been reported to be able to improve gut permeability and modulate the immunologic system, thereby decreasing postoperative complications. Therefore we aimed to evaluate the postoperative use of symbiotics in head and neck cancer surgical patients for intestinal function and permeability, as well as the postoperative outcomes. Patients were double-blind randomised into the symbiotic (n18) or the control group (n18). Samples were administered twice a day by nasoenteric tube, starting on the 1st postoperative day until the 5th to 7th day, and comprised 109colony-forming units/ml each ofLactobacillus paracasei,L. rhamnosus,L. acidophilus, andBifidobacterium lactisplus 6 g of fructo-oligosaccharides, or a placebo (6 g of maltodextrin). Intestinal function (day of first evacuation, total stool episodes, stool consistency, gastrointestinal tract symptoms and gut permeability by diamine oxidase (DAO) enzyme) and postoperative complications (infectious and non-infectious) were assessed. Results of comparison of the pre- and postoperative periods showed that the groups were similar for all outcome variables. In all, twelve patients had complications in the symbiotic groupv. nine in the control group (P>0·05), and the preoperative-postoperative DAO activity ranged from 28·5 (sd15·4) to 32·7 (sd11·0) ng/ml in the symbiotic group and 35·2 (sd17·7) to 34·1 (sd12·0) ng/ml in the control group (P>0·05). In conclusion, postoperative symbiotics did not impact on intestinal function and postoperative outcomes of head and neck surgical patients.
The association of social support networks and loneliness with negative perceptions of ageing: evidence from the Irish Longitudinal Study on Ageing (TILDA)
Authors: SANTINI ZIGGI IVAN , KOYANAGI AI , TYROVOLAS STEFANOS , HARO JOSEP MARIA , KOUSHEDE VIBEKE 
Published: December 2017

ABSTRACTIt is well known that negative ageing perceptions have various detrimental effects on indicators of successful ageing, but less is known about the role of social support networks and loneliness in ageing perceptions. The objective of this study was therefore to assess the association of social networks, relationship quality and loneliness with negative ageing perceptions in late life. Cross-sectional data on 6,912 adults aged ⩾50 years from the first wave of the Irish Longitudinal Study on Ageing (TILDA) were analysed. Ageing perceptions were assessed with the Brief Ageing Perceptions Questionnaire. Information on social support networks, loneliness and socio-demographics were obtained using standard questions. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression scale. Multivariable linear regression was conducted to assess the associations. Social isolation, poor relationship quality (with spouse, children, other family members or friends) and loneliness were all significantly associated with negative ageing perceptions even after adjustment for all potential confounders including depressive symptoms. Our study indicates that targeting integration into social support networks and improving relationship quality may potentially reduce the extent to which older individuals adopt negative ageing perceptions. Future studies with prospective design are warranted to understand the temporal direction and causal association of social support networks and loneliness with negative ageing perceptions.
CHARACTERISTICS OF MANAGED ENTRY AGREEMENTS IN AUSTRALIA
Authors: Robinson Maxine F. , Mihalopoulos Cathrine , Merlin Tracy , Roughead Elizabeth 
Published: December 2017

Objectives:Australia relies on managed entry agreements (MEAs) for many medicines added to the national Pharmaceutical Benefits Scheme (PBS). Previous studies of Australian MEAs examined public domain documents and were not able to provide a comprehensive assessment of the types and operation of MEAs. This study used government documents approved for release to examine the implementation and administration of MEAs implemented January 2012 to May 2016.Methods:We accessed documents for medicines with MEAs on the PBS between January 2012 and May 2016. Data were extracted on Anatomical Therapeutic Classification (ATC), type of MEA (financial, financial with outcomes, outcomes, and subcategories within each group), implementation and administration methods, source of MEA recommendation, and type of economic analysis.Results:Of all medication indication pairs (MIPs) recommended for listing, one-third had MEAs implemented. Our study of eighty-seven MIPs had 170 MEAs in place. The Government's expert health technology assessment (HTA) committee recommended MEAs for 90 percent of the eighty-seven MIPs. A total of 81 percent of MEAs were simple financial agreements: the majority either discounts (32 percent) or reimbursement caps (43 percent). Outcome-based MEAs were least common (5 percent). Ninety-two percent of MEAs were implemented and operated through legal agreements. Approximately half of the MIPs were listed on the basis of accepted claims of cost-minimization. Forty-nine percent of medicines were in ATC L group.Conclusion:Advice from HTA evaluations strongly influences the implementation of ways to manage uncertainties while providing access to medicines. The government relied primarily on simple financial agreements for the managed entry of medicines for which there were perceived risks.