bluuebunny/crossref_metadata_2025_split huggingface dataset:
Message framing's limited efficacy in counteracting parental hesitancy towards human papillomavirus vaccination for female adolescents: Insights from a randomized trial
Authors: Shi Naiyang , Liang Jie , Yi Youqin , Miao Ruishuai , Yang Xuying , Yang Liuqing , Tao Tingsu , Zhang Yanlin , Jin Hui , Zheng Xiaoyan 
Published: October 2024

AbstractBackgroundParental acceptance of HPV vaccination remains low. This study investigates the influence of different message framing on Chinese parental intentions to vaccinate their daughters against HPV.MethodsA 2 (appeal framing: gain vs. loss) × 2 (cultural value: individualism vs. collectivism) × 2 (evidence type: narrative vs. non‐narrative) factorial design was used in an online experiment. Parents of unvaccinated junior high school girls were recruited and included in the experiment. The primary outcome assessed was the reduction in HPV vaccine hesitancy (VH). The analysis of variance tests (ANOVAs) and hierarchical regression analyses were conducted to test the hypotheses.ResultsOf 4012 participants, the majority were women with low VH. Only loss‐framing exerted a direct effect on advocacy (p = .036). Initial VH negatively moderated this effect (p = .027). Except for narrative evidence (p = .068), message framings showed significant small effects in low‐hesitant participants (p = .032). An incentive policy negatively moderated the initial VH's effect on advocacy (p = .042). Persuasion was evident only among low‐hesitant participants not receiving incentives (p = .002). In contrast, for highly hesitant individuals without incentive policies, loss‐framing (p = .024) and collectivism perspective (p = .033) produced counterintuitive effects.ConclusionsMessage framing is effective among low‐hesitant parents of female adolescents in improving HPV vaccination decisions without economic incentives. Non‐narrative evidence and loss‐framing messages should be prioritized over narrative evidence and gain‐framing messages. Nonetheless, caution is warranted when engaging with highly hesitant parents.
EthoCRED: a framework to guide reporting and evaluation of the relevance and reliability of behavioural ecotoxicity studies
Authors: Bertram Michael G. , Ågerstrand Marlene , Thoré Eli S.J. , Allen Joel , Balshine Sigal , Brand Jack A. , Brooks Bryan W. , Dang ZhiChao , Duquesne Sabine , Ford Alex T. , Hoffmann Frauke , Hollert Henner , Jacob Stefanie , Kloas Werner , Klüver Nils , Lazorchak Jim , Ledesma Mariana , Maack Gerd , Macartney Erin L. , Martin Jake M. , Melvin Steven D. , Michelangeli Marcus , Mohr Silvia , Padilla Stephanie , Pyle Gregory , Saaristo Minna , Sahm René , Smit Els , Steevens Jeffery A. , van den Berg Sanne , Vossen Laura E. , Wlodkowic Donald , Wong Bob B.M. , Ziegler Michael , Brodin Tomas 
Published: October 2024

ABSTRACTBehavioural analysis has been attracting significant attention as a broad indicator of sub‐lethal toxicity and has secured a place as an important subdiscipline in ecotoxicology. Among the most notable characteristics of behavioural research, compared to other established approaches in sub‐lethal ecotoxicology (e.g. reproductive and developmental bioassays), are the wide range of study designs being used and the diversity of endpoints considered. At the same time, environmental hazard and risk assessment, which underpins regulatory decisions to protect the environment from potentially harmful chemicals, often recommends that ecotoxicological data be produced following accepted and validated test guidelines. These guidelines typically do not address behavioural changes, meaning that these, often sensitive, effects are not represented in hazard and risk assessments. Here, we propose a new tool, the EthoCRED evaluation method, for assessing the relevance and reliability of behavioural ecotoxicity data, which considers the unique requirements and challenges encountered in this field. This method and accompanying reporting recommendations are designed to serve as an extension of the “Criteria for Reporting and Evaluating Ecotoxicity Data (CRED)” project. As such, EthoCRED can both accommodate the wide array of experimental design approaches seen in behavioural ecotoxicology, and could be readily implemented into regulatory frameworks as deemed appropriate by policy makers of different jurisdictions to allow better integration of knowledge gained from behavioural testing into environmental protection. Furthermore, through our reporting recommendations, we aim to improve the reporting of behavioural studies in the peer‐reviewed literature, and thereby increase their usefulness to inform chemical regulation.
Exome Sequencing of Consanguineous Pashtun Families With Familial Epilepsy Reveals Causative and Candidate Variants in TSEN54, MOCS2, and OPHN1
Authors: Khan Afrasiab , Muhammad Anees , Ullah Hidayat , Ambreen Hina , Ullah Abeed , May Patrick , Lerche Holger , Haack Tobias B. , Rehman Shoaib ur , Kegele Josua 
Published: October 2024

ABSTRACTNext‐generation sequencing is advancing in low‐ and middle‐income countries, but accessibility remains limited. In Pakistan, many members of the Pashtun population practice familial marriage and maintain distinct socio‐cultural traditions, isolating them from other ethnic groups. As a result, they may harbor genetic variants that could unveil new gene‐disease associations. To investigate the genetic basis of epilepsy in the Pashtun community we recently established a collaboration between Bannu University and the University of Tuebingen. Here we report our first results of exome sequencing of four families with presumed monogenetic epilepsy and Mendelian inheritance pattern. In Family #201, we identified distinct disease‐causing variants. One had a homozygous pathogenic missense variant in TSEN54 (c.919G > T, p.(Ala307Ser)), linked to Pontocerebellar Hypoplasia Type 2A. The second individual had a homozygous class IV missense variant in MOCS2 (c.226G > A, p.(Gly76Arg)) which is associated with Molybdenum cofactor deficiency. In family EP02, one affected individual carried a heterozygous class III variant in OPHN1 (c.1490G > A, p.(Arg497Gln)), related to syndromic X‐linked intellectual disability with epilepsy. Our small study demonstrates the promise of next‐generation sequencing in genetic epilepsies among the Pashtun population. Diagnostic next‐generation sequencing should be established in Pakistan as soon as possible, and if not feasible, genetic research projects may pioneer this path.
A Simple Computational Model of Semantic Priming in 18‐Month‐Olds
Authors: Gliozzi Valentina 
Published: October 2024

AbstractWe propose a simple computational model that describes potential mechanisms underlying the organization and development of the lexical‐semantic system in 18‐month‐old infants. We focus on two independent aspects: (i) on potential mechanisms underlying the development of taxonomic and associative priming, and (ii) on potential mechanisms underlying the effect of Inter Stimulus Interval on these priming effects. Our model explains taxonomic priming between words by semantic feature overlap, whereas associative priming between words is explained by Hebbian links between semantic representations derived from co‐occurrence relations between words (or their referents). From a developmental perspective, any delay in the emergence of taxonomic priming compared to associative priming during infancy seems paradoxical since feature overlap per se need not be learned. We address this paradox in the model by showing that feature overlap itself is an emergent process. The model successfully replicates infant data related to Inter Stimulus Interval effects in priming experiments and makes testable predictions.
Collaborative conservation for snow leopards: Lessons learned from successful community‐based interventions
Authors: Young Juliette Claire , Alexander Justine Shanti , Agvaantseren Bayarjargal , Bijoor Ajay , Butler Adam , Nawaz Muhammad Ali , Piaopiao Tang , Searle Kate R. , Uulu Kuban Zhumabai , Zhi Lu , Suryawanshi Kulbhushansingh Ramesh , Redpath Stephen M. , Mishra Charudutt 
Published: October 2024

AbstractCollaborative conservation interventions based on engagement with local communities are increasingly common, especially for large carnivores that negatively impact people's livelihoods and well‐being. However, evaluating the effectiveness of large‐scale community‐based conservation interventions is rarely done, making it problematic to assess or justify their impact. In our study focused on snow leopards (Panthera uncia) in five countries, we show that bespoke and well‐implemented community‐based and conflict management intervention efforts can lead to more sustainable conservation outcomes. Collaborative interventions, spread over about 88,000 km2 of snow leopard habitat, reduced livestock depredation and disease and associated economic costs. Additionally, they generated conservation‐linked livelihoods and enhanced community decision‐making, leading to more positive behavioral intent toward snow leopards and improved communities’ cooperation, economic security, and confidence. Our results provide lessons learned and recommendations for practitioners and governments to alleviate conflicts and foster coexistence with snow leopards and large carnivores more broadly. These include prioritizing locally led tailored solutions based on the PARTNERS principles, recognizing local community rights in conservation decision‐making, and recognizing the role of social norms in ensuring accountability.
Minimum wages and foster care placement disruption
Authors: Neymotin Florence , Hawks William 
Published: October 2024

AbstractWe examine the potential secondary impacts of raising the minimum wage in a jurisdiction on the efficiency of its foster care placement system. We employ the Adoption and Foster Care Analysis and Reporting System (AFCARS) restricted‐access dataset representing all children in the US foster care system for the years 2000–21. We calculate placement efficiency as the number of yearly moves experienced by a child in the foster care system, with a decrease in the number of placements interpreted as benefitting children both psychologically and behaviourally. This increase in stability benefits the foster parents and corresponds to a smaller financial strain on the public. After including various controls and state‐year fixed effects, our Tobit and Ordinary Least Squares (OLS) analyses find that increased minimum wages are significantly associated with lower levels of placement disruption. We take this as promising initial descriptive evidence for the secondary effects of the minimum wage on reducing the financial burden, and increasing the placement efficiency, of the foster care system.
Glucagon and glucagon‐like peptide‐1 dual agonist therapy: A possible future towards fatty kidney disease
Authors: Kanbay Mehmet , Copur Sidar , Guldan Mustafa , Ozbek Lasin , Mallamaci Francesca , Zoccali Carmine 
Published: October 2024

AbstractBackgroundObesity is a growing epidemic affecting approximately 40% of the adult population in developed countries with major health consequences and comorbidities, including diabetes mellitus and insulin resistance, metabolically associated fatty liver disease, atherosclerotic cardiovascular and cerebrovascular diseases and chronic kidney disease. Pharmacotherapies targeting significant weight reduction may have beneficial effects on such comorbidities, though such therapeutic options are highly limited. In this narrative review, we aim to evaluate current knowledge regarding dual agonist therapies and potential implications for managing fatty kidney and chronic kidney disease.Results and ConclusionGlucagon‐like peptide‐1 agonists and sodium‐glucose cotransporter‐2 inhibitors are two novel classes of glucose‐lowering medications with potential implications and beneficiary effects on renal outcomes, including estimated glomerular filtration rate, albuminuria and chronic kidney disease progression. Recently, dual agonist therapies targeting glucagon‐like peptide‐1 and glucagon receptors, namely survodutide and cotadutide, have been evaluated in managing metabolically associated fatty liver disease, a well‐established example of visceral obesity. Fatty kidney is another novel concept implicated in the pathophysiology of chronic kidney disease among patients with visceral obesity.
Modification, validation and comparison of Naples prognostic score to determine in‐hospital mortality in ST‐segment elevation myocardial infarction
Authors: Genc Omer , Yildirim Abdullah , Erdogan Aslan , Ibisoglu Ersin , Guler Yeliz , Capar Gazi , Goksu M. Mert , Akgun Huseyin , Acar Gamze , Ozdogan G. Cansu , Uredi Gunseli , Sen Furkan , Halil Ufuk S. , Er Fahri , Genc Murside , Ozkan Eyup , Guler Ahmet , Kurt Ibrahim H. 
Published: October 2024

AbstractAimThe relationship between inflammatory status and poor outcomes in acute coronary syndromes is a significant area of current research. This study investigates the association between in‐hospital mortality and the modified Naples prognostic score (mNPS) as well as other inflammatory biomarkers in STEMI patients.MethodsThis single‐centre, cross‐sectional study included 2576 consecutive STEMI patients who underwent primary percutaneous coronary intervention between January 2022 and November 2023. Participants were randomly divided into derivation and validation cohorts in a 6:4 ratio. The following inflammatory indices were calculated: pan‐immune‐inflammation value (PIV), systemic immune‐inflammation‐index (SII), systemic inflammation‐response index (SIRI) and conventional NPS. The mNPS was derived by integrating hs‐CRP into the conventional NPS. The performance of these indices in determining in‐hospital mortality was assessed using regression, calibration, discrimination, reclassification and decision curve analyses.ResultsInflammatory biomarkers, including PIV, SII, SIRI, NPS and mNPS, were significantly higher in patients who died during in‐hospital follow‐up compared to those discharged alive in both the derivation and validation cohorts. Multivariable logistic regression analyses were performed separately for the derivation and validation cohorts. In the derivation cohort, mNPS was associated with in‐hospital mortality (aOR = 1.490, p < .001). Similarly, in the validation cohort, mNPS was associated with in‐hospital mortality (aOR = 2.023, p < .001). mNPS demonstrated better discriminative and reclassification power than other inflammatory markers (p < .05 for all). Additionally, regression models incorporating mNPS were well‐calibrated and showed net clinical benefit in both cohorts.ConclusionmNPS may be a stronger predictor of in‐hospital mortality in STEMI patients compared to the conventional scheme and other inflammatory indices.
Downstream Migration Success of Atlantic Salmon Smolts in a River Catchment Highly Fragmented by Hydroelectric Impoundments
Authors: Rodger Jessica R. , Kaiser‐Wilks Phoebe , Beck Samantha V. , Ribbens Jamie C. H. , Lothian Angus J. , Adams Colin E. 
Published: October 2024

ABSTRACTRiverine habitat fragmentation by barriers, including impoundments, is common and their effects on obligate aquatic organisms are manifold. Organisms, such as Atlantic salmon (Salmo salar), that make extensive river migrations are particularly vulnerable to the effects of impoundments. In this study, we use acoustic telemetry to examine the migratory behaviour of Atlantic salmon, as they migrate to sea for the first time as juvenile ‘smolts’, in a river with a series of dams that form a complex hydropower scheme. We demonstrate that overall migration success in the River Dee catchment and particularly through standing waters was remarkably high. We speculate that high migration success in standing waters could be due to relative current speeds providing good quality directional cues to migrants. Migration success past the two dams in this study, was relatively high, although the number of unsuccessful passage attempts before a successful passage was also very high. The vast majority of smolts passed the dams when the turbines were operational. At one dam, smolts did not use an available fish pass but migrated through the generating turbines. These findings provide several routes through which generation could be managed to enhance the success of downstream smolt migration in rivers where there are similar patterns of hydrogeneration in place.
Proteomic Profiling of Lymph Nodes Differentiates Classic Hodgkin Lymphoma With and Without Skeletal Involvement
Authors: Andersen Maja Dam , Wolter Katharina , Enemark Marie Beck Hairing , Pedersen Mette Abildgaard , Gormsen Lars Christian , Lauridsen Kristina Lystlund , Starklint Jørn , Hamilton‐Dutoit Stephen Jacques , d'Amore Francesco , Ludvigsen Maja , Honoré Bent , Kamper Peter 
Published: October 2024

ABSTRACTClassic Hodgkin lymphoma (CHL) is a highly curable disease, even in advanced stages. Controversy remains over whether bone involvement negatively affects overall and progression‐free survival in patients treated with intensive chemotherapy regimens. Whether cases that present with bone lesions harbor specific tumor microenvironmental features is unknown. We investigated protein expression in diagnostic lymph node biopsies from CHL patients with and without skeletal involvement at diagnosis to identify potential markers of skeletal disease. Protein expression patterns in diagnostic formalin‐fixed paraffin‐embedded lymphoma lymph node samples from CHL patients were analyzed by nano‐liquid chromatography–tandem mass spectrometry. Patients were grouped according to skeletal involvement, which was defined as the presence of one or more FDG‐avid lesions on a diagnostic FDG‐PET/CT scan. Protein profiles identified patients with skeletal disease at diagnosis and showed disrupted cellular pathways, including immune system processes, cell adhesion, and cell growth/survival. Immunohistochemical evaluation also demonstrated differential expressions of angiotensin‐converting enzyme (ACE), intercellular adhesion molecule 3 (ICAM3), integrin alpha‐X (ITGAX), and calreticulin (CALR). In conclusion, proteomics identified altered protein expression profiles in lymph nodes among CHL cases presenting with disease disseminated to the skeletal system, which implies altered disease pathogenesis for these patients.
Anomalous recognition of flicker‐fused letters
Authors: Greene Ernest , Morrison Jack , Wang Wei 
Published: October 2024

AbstractFlash sequences appear as steady emission of light if the frequency is above the flicker‐fusion threshold. One can display flicker‐fused letters against a background, and using the Talbot‐Plateau law, vary the average luminance of the letters to control degree of match to background luminance. We have previously reported that the visual system can identify letters that have an average luminance that equals background luminance, which can be described as an anomalous contrast discrimination. The present work confirms the earlier report, and provides additional evidence that the phenomenon is not based on a shift in luminance balance. We discuss the possible role of ON and OFF retinal channels in registering the anomalous contrast.
Purification and characterisation of a homogenised protein from Red Deer (Cervus elaphus) abomasum as a potential hyaluronidase inhibitor
Authors: Yang Zi , Wali Ahmidin , Arken Amina , Dongmulati Naziermu , Hu Ailin , Gao Yanhua , Yili Abulimiti , Aisa HajiAkber 
Published: October 2024

SummaryTo improve the utilisation of abomasum and explore the material basis of its antioxidant and hyaluronidase inhibitory activities, a homogeneous protein RDA4‐1 was isolated from the abomasum of cultured red deer by two‐step chromatography process for the first time in this study. It has a molecular weight of 15 kDa and comprises 43.56% essential amino acids. RDA4‐1 scavenged 50.97% of DPPH• and 88.37% of ABTS+· at 1.5 mg mL−1, and inhibited hyaluronidase by 79.23% at 1 mg mL−1. The CD and fluorescence spectroscopy was used to initiate explore the hyaluronidase inhibition reaction process. With an increase in the concentration of RDA4‐1 in the inhibition reaction, the wavelength of the negative peak of CD shifted from 208 to 218 nm, and the absorption of the positive peak of CD increased from 0.5 to 8.3 mdeg. Furthermore, fluorescence absorption at a wavelength of 340 nm rose from 248 to 762 au. These findings suggest that the interaction of RDA4‐1 with hyaluronidase induces alterations in the secondary structure of the protein complex, and RDA4‐1 binds reversibly to the enzyme in a non‐covalent manner. The results of this study indicate that RDA4‐1 could serve as a potential hyaluronidase inhibitor in the development of nutraceuticals.
Evaluating the multifaceted impact of Cephalaria extract on dough quality: Antioxidant, antimicrobial, and cytotoxic properties
Authors: Bağdat Elif Şeyma , Bozkurt Fatih , Kahraman Ilıkkan Özge , Sagdic Osman , Törnük Fatih 
Published: October 2024

SummaryCephalaria syriaca, known as cephalaria, is an annual, pilose plant with pink‐purple flowers growing wild in wheat fields. Viscoelastic properties of gluten‐free doughs can be improved by adding cephalaria. However, this addition results in some undesirable properties in bread such as bitter taste and dark internal colour. This study aimed to reduce these effects by obtaining cephalaria obtained from distilled water and ethanol extracts and to increase the potential use of extracts in bread production. Different proportions of water and ethanol extracts obtained from oil‐free cephalaria were added to bread by creating a model with Mixture Design, and the optimum concentration was determined by farinograph trials. The antioxidative, antimicrobial, and cytotoxic effects of extract and the effect of cephalaria on yeast activity were examined. Cephalaria extracts had no measurable antimicrobial effect and no antifungal effect on Rhizopus stolonifer, while an antifungal effect was found against A. niger and P. expansum. The IC50 value was found to be 4.15 mg mL−1 for ethanol extract while the water extract had no effect on cells. The addition of extract had no negative effect on the number of yeasts in sourdough fermentation. The study has improved the usage of cephalaria by using water and ethanol extracts in dough.
The effect of downstream translocation on Atlantic salmon Salmo salar smolt outmigration success
Authors: Forrester Ruaidhri , Honkanen Hannele M. , Lilly Jessie , Green Amy , Rodger Jessica R. , Shields Brian A. , Ramsden Philip , Koene J. Peter , Fletcher Melanie , Bean Colin W. , Adams Colin E. 
Published: October 2024

AbstractTrap and transport, the capture and subsequent translocation of fish during the freshwater phase of their migration, is becoming more common as a management intervention. Although the technique can be successful, it is costly and can have unintended effects on the fish being transported. This study investigates whether trap and transport can be used to increase the migration success of Atlantic salmon, Salmo salar, smolts in naturally flowing rivers. Seaward‐migrating S. salar (n = 294) from two UK rivers were tracked using acoustic telemetric techniques. Outmigration success and timing were compared between non‐transported (released at the original in‐river capture site) and transported (released ca. 23 km downstream of the capture site) individuals. Downstream translocation increased the proportion of fish that successfully migrated to marine waters, and there was no indication that transport reduced post‐release survival. The post‐release migration speed of transported fish was slower than expected but this was likely a function of their advanced migration timing rather than an inhibition of their capacity to migrate. These results suggest that trap and transport can increase the outmigration success of S. salar smolts, but the earlier river exit dates of transported fish could negatively affect their survival at sea.