bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nursing diagnoses related to psychiatric adult inpatient care
Authors: Frauenfelder Fritz , van Achterberg Theo , Müller Staub Maria 
Published: July 2017

Aims and objectivesTo detect the prevalence of NANDA‐I diagnoses and possible relationships between those and patient characteristics such as gender, age, medical diagnoses and psychiatric specialty/setting.BackgroundThere is a lack on studies about psychiatric inpatient characteristics and possible relationships among these characteristics with nursing diagnoses.DesignA quantitative‐descriptive, cross‐sectional, completed data sampling study was performed.MethodsThe data were collected from the electronic patient record system. Frequencies for the social‐demographic data, the prevalence of the NANDA‐I diagnoses and the explanatory variables were calculated.ResultsIn total, 410 nursing phenomena were found representing 85 different NANDA‐I diagnoses in 312 patients. The NANDA‐I diagnosis “Ineffective Coping” was the most frequently stated diagnosis followed by “Ineffective Health Maintenance,” “Hopelessness” and “Risk for Other‐Directed Violence”. Men were more frequently affected by the diagnoses “Ineffective Coping,” “Hopelessness,” “Risk for Self‐Directed Violence,” “Defensive Coping” and “Risk for Suicide,” whereas the diagnoses “Insomnia,” “Chronic Confusion,” “Chronic Low Self‐Esteem” and “Anxiety” were more common in women. Patients under the age of 45 years were more frequently affected by “Chronic Low Self‐Esteem” and “Anxiety” than older patients. “Ineffective Coping” was the most prevalent diagnosis by patients with mental disorders due to psychoactive substance use. Patients with schizophrenia were primarily affected by the diagnoses “Ineffective Coping,” “Impaired Social Interaction” and “Chronic Low Self‐Esteem.”ConclusionsThis study demonstrates the complexity and diversity of nursing care in inpatient psychiatric settings. Patients’ gender, age and psychiatric diagnoses and settings are a key factor for specific nursing diagnosis.Relevance to clinical practiceThere are tendencies for relationships between certain nursing diagnosis and patient characteristics in psychiatric adult inpatients. This enhances the specific, extended knowledge for nursing care and its demands in this setting and therefore supports the daily nursing psychiatric care and its needs.
Topotecan-loaded lipid nanoparticles as a viable tool for the topical treatment of skin cancers
Authors: Venâncio João Hélio , Andrade Lígia Marquez , Esteves Najla Locatelli Santos , Brito Lara Barroso , Valadares Marize Campos , Oliveira Gisele Augusto Rodrigues , Lima Eliana Martins , Marreto Ricardo Neves , Gratieri Tais , Taveira Stephânia Fleury 
Published: July 2017

Abstract

Objectives
This work aimed to evaluate semisolid formulations containing topotecan (TPT) loaded nanostructured lipid carriers (NLC) for topical treatment of skin cancers, as TPT is effective against a variety of tumours. A formulation which increases TPT skin permeation would be extremely desirable.

Methods
TPT-NLC were prepared and incorporated in hydrogels with hydroxyethyl cellulose and chitosan (TPT-NLC-HEC and TPT-NLC-Ch, respectively). Control formulations were obtained by dispersing TPT in HEC and Ch hydrogels (TPT-HEC and TPT-Ch).

Key findings
TPT-NLC-HEC and TPT-NLC-Ch showed to maintain the drug and nanoparticle dispersions stable for up to 30 days. When nanoparticles were incorporated into gels, TPT release was significantly decreased (P &lt; 0.05). Still, TPT-NLC-HEC increased 2.37 times permeation compared with TPT-HEC (11.9 and 5.0 μg/cm2, respectively). Cell culture experiments with B16F10 melanoma demonstrated that nanoencapsulation significantly increased TPT cytotoxicity (P &lt; 0.05). TPT-NLC was more toxic than free TPT, with IC50 value of 5.74 μg/ml, whereas free TPT had an IC50 &gt; 20 μg/ml. As skin permeated values of TPT from developed formulation (TPT-NLC) were superior to melanoma IC50, it can be extrapolated that chemotherapeutic permeated amounts may be sufficient for a therapeutic effect.

Conclusions
TPT-NLC-HEC may be a valuable tool for the topical treatment of skin cancers.
Disinfection of the peritoneal dialysis bag medication port: Comparison of disinfectant agent and disinfection time
Authors: Conti Adriana , Katzap Roberta M , Poli‐de‐Figueiredo Carlos E , Pagnussatti Vany , Figueiredo Ana E 
Published: July 2017

Summary at a GlanceThis is an in vitro study looking at the effectiveness of the types and duration of application of disinfectants in eliminating several micro‐organisms at the medication port of peritoneal dialysis bags. The authors found that disinfecting with 2% chlorhexidine for at least 5 s was effective.
Successful treatment of chronic hepatitis C infection with directly acting antivirals in renal transplant recipients
Authors: Taneja Sunil , Duseja Ajay , De Arka , Kumar Vivek , Ramachandran Raja , Sharma Ashish , Dhiman Radha K , Gupta Krishan L , Chawla Yogesh 
Published: July 2017

Summary at a GlanceThis is a single‐centre case series reporting the efficacy and safety of direct acting antivirals in the treatment of chronic hepatitis C infection after kidney transplantation in India. Treatment with these antivirals was highly effective in achieving sustained viral clearance, without compromising renal allograft function.
Perturbation approaches for integral projection models
Authors: Griffith Alden B. 
Published: July 2017

Perturbation analysis of population models is fundamental to elucidating mechanisms of population dynamics and examining scenarios of change. The use of integral projection models (IPMs) has increased in the last decade, and while many of the tools and approaches developed for matrix models remain relevant, the nature of IPMs expands the framework of perturbation analysis, with different approaches often requiring important considerations. This article provides a review of – and practical guide to – different perturbation approaches for IPMs, formalizes methodologies for perturbing IPM size transition probabilities, and highlights areas where researchers should be particularly careful and critical when conducting and interpreting perturbation analysis. I use a simulated dataset to compare five hierarchical perturbation approaches for IPMs found within 63 published studies, and apply a combination of approaches to the example of an invasive perennial plant. Other perturbation approaches for IPMs are also highlighted.Most perturbation analyses for IPMs to date have focused on the response of the asymptotic population growth rate (λ) to changes in elements of the discretized projection kernel and/or the growth– survival and reproduction– recruitment sub‐kernels. Perturbations to vital rate functions and regression predictions underlying these kernels provide mechanistic insight, but are less common and can require important considerations regarding the perturbation of size transitions separate from survival and the nature of the state variable (used to represent size). The second most common approach is more specific to IPMs and examines the influence of vital rate regression parameters, each of which can have broad influence on the population growth rate. Researchers using IPMs have many perturbation options available and should carefully consider which approach or combination of approaches is most applicable and interpretable for their specific questions.
5‐aminolaevulinic acid patch‐photodynamic therapy in the treatment of actinic cheilitis
Authors: Radakovic Sonja , Tanew Adrian 
Published: July 2017

SummaryBackgroundActinic cheilitis (AC) is a common disease caused by chronic ultraviolet exposure.ObjectiveAlacare is a self‐adhesive, skin coloured 5‐aminolaevulinic acid (ALA) patch that has been developed for the treatment of mild to moderate actinic keratosis (AK). Considering the good results in the treatment of AK, the standardized delivery of ALA and the simple application Alacare patch‐ photodynamic therapy (PDT) appears as an interesting treatment option for AC.MethodsWe retrospectively assessed the efficacy, tolerability and cosmetic outcome of Alacare patch‐PDT in eleven patients with AC. After occlusion with the Alacare patches for 4 hours, the AC lesions were illuminated with narrowband red light and a dose of 37 J/cm2. All patients were clinically assessed for efficacy, side effects and cosmetic outcome at 3, 6, 9 and 12 months after treatment.ResultsComplete clinical response at the 3‐month follow‐up was achieved in eight of 11 patients (72,7%) and 12 of 15 AC lesions (80,0%), respectively. Up to the final 12‐month follow‐up, a recurrence was observed in two lesions. The complete clinical cure rate at 1 year after Alacare patch‐PDT, thus, was 66,6% (10/15 lesions). The cosmetic outcome of the treatment was excellent in all cases.ConclusionAlacare patch‐PDT was found to have substantial efficacy in the treatment of mild to moderate AC. Given its ease of use, absence of long‐term side effects and the excellent cosmetic results Alacare patch‐PDT might be considered as a promising new treatment option for the management of AC.
Race scholarship “with, by, and for” children: How critical youth studies can inform research on race
Authors: Hagerman Margaret Ann 
Published: July 2017

AbstractChildren's perspectives on race and their own racialized experiences are often overlooked in traditional social scientific race scholarship. From psychological and child development studies of racial identity formation, to social psychological survey research on children's racial attitudes, to sociological research conductedonchildren in order to quantify racially disproportionate child outcomes, the unique perspectives of young people are often marginalized. I explore some of the key themes in existing sociological and psychological research involving race and young people and demonstrate the important contributions of this expansive body of scholarship but also highlight limitations. I argue that when it comes specifically to the sociological study of young people and race, much can be learned from an emerging field known as “critical youth studies.” Further, I argue that more research on race that, as Kate Telleczek (2014, p. 16) describes, is “with,by, andfor” young people, grounded in the epistemological and methodological tenants of critical youth studies, can lead to new sociological understandings of race and childhood, serve to inform public policies and practices intended to improve children's lives, and provide a platform for young people to express their own concerns and ideas about the racialized society in which they live.
The operational implications of donor behaviors following enrollment in STRIDE (Strategies to Reduce Iron Deficiency in blood donors)
Authors: Cable Ritchard G. , Birch Rebecca J. , Spencer Bryan R. , Wright David J. , Bialkowski Walter , Kiss Joseph E. , Rios Jorge , Bryant Barbara J. , Mast Alan E. 
Published: July 2017

BACKGROUNDDonor behaviors in STRIDE (Strategies to Reduce Iron Deficiency), a trial to reduce iron deficiency, were examined.STUDY DESIGN AND METHODSSix hundred ninety‐two frequent donors were randomized to receive either 19 or 38 mg iron for 60 days or an educational letter based on their predonation ferritin. Compliance with assigned pills, response to written recommendations, change in donation frequency, and future willingness to take iron supplements were examined.RESULTSDonors who were randomized to receive iron pills had increased red blood cell donations and decreased hemoglobin deferrals compared with controls or with pre‐STRIDE donations. Donors who were randomized to receive educational letters had fewer hemoglobin deferrals compared with controls. Of those who received a letter advising of low ferritin levels with recommendations to take iron supplements or delay future donations, 57% reported that they initiated iron supplementation, which was five times as many as those who received letters lacking a specific recommendation. The proportion reporting delayed donation was not statistically different (32% vs. 20%). Of donors who were assigned pills, 58% reported taking them “frequently,” and forgetting was the primary reason for non‐compliance. Approximately 80% of participants indicated that they would take iron supplements if provided by the center.CONCLUSIONSDonors who were assigned iron pills had acceptable compliance, producing increased red blood cell donations and decreased low hemoglobin deferrals compared with controls or with pre‐STRIDE rates. The majority of donors assigned to an educational letter took action after receiving a low ferritin result, with more donors choosing to take iron than delay donation. Providing donors with information on iron status with personalized recommendations was an effective alternative to directly providing iron supplements.
Transient hemolysis due to anti‐D and anti‐A1 produced by engrafted donor's lymphocytes after allogeneic unmanipulated haploidentical hematopoietic stem cell transplantation
Authors: Bailén Rebeca , Kwon Mi , Pérez‐Corral Ana María , Pascual Cristina , Buño Ismael , Balsalobre Pascual , Serrano David , Gayoso Jorge , Díez‐Martín José Luis , Anguita Javier 
Published: July 2017

BACKGROUNDDevelopment of de novo alloantibodies against recipient's red blood cell (RBC) antigens by engrafted donor's lymphocytes is a known phenomenon in the setting of allogeneic hematopoietic stem cell transplantation (HSCT). This situation is usually clinically insignificant. We report a case of early clinically relevant hemolytic anemia in a blood group A1 D+ patient, due to a limited production of anti‐D and anti‐A1 produced by nonpreviously sensitized newly engrafted donor's immune system.CASE REPORTA 31‐year‐old Caucasian woman, blood group A1, D+, with Hodgkin's lymphoma, received an unmanipulated haploidentical allogeneic peripheral blood HSCT after a nonmyeloablative conditioning regimen. Donor blood group was A2B, D–. The patient had an uneventful course until Day +34, when she developed clinically significant hemolytic anemia with a positive direct antiglobulin test. Anti‐D and anti‐A1 produced by the donor‐engrafted lymphocytes were detected both in serum and in eluate. The hemolysis produced an accelerated group change, turning the patient's ABO group into A2B 2 weeks after the detection of the alloantibodies. As the residual patient's RBCs progressively disappeared, anti‐D and anti‐A1 production decreased and were not detected in serum by Day +41.CONCLUSIONThis case illustrates that de novo alloantibody production against ABO and D antigens by the newly engrafted donor's lymphocytes can occasionally cause clinically significant anemia. To our knowledge, this is the first case reported of clinically significant hemolytic anemia due to a transient anti‐D anti‐A1 alloimmunization after T‐cell‐repleted haploidentical HSCT.
Implementation of a new blood cooler insert and tracking technology with educational initiatives and its effect on reducing red blood cell wastage
Authors: Fadeyi Emmanuel A. , Emery Wanda , Simmons Julie H. , Jones Mary Rose , Pomper Gregory J. 
Published: July 2017

BACKGROUNDThe objective was to report a successful implementation of a blood cooler insert and tracking technology with educational initiatives and its effect on reducing red blood cell (RBC) wastage.STUDY DESIGN AND METHODSThe blood bank database was used to quantify and categorize total RBC units issued in blood coolers from January 2010 to December 2015 with and without the new inserts throughout the hospital. Radiofrequency identification tags were used with special software to monitor blood cooler tracking. An educational policy on how to handle the coolers was initiated. Data were gathered from the software that provided a real‐time location monitoring of the blood coolers with inserts throughout the institution.RESULTSThe implementation of the blood cooler with inserts and tracking device reduced mean yearly RBC wastage by fourfold from 0.64% to 0.17% between 2010 and 2015. The conserved RBCs corresponded to a total cost savings of $167,844 during the 3‐year postimplementation period.CONCLUSIONSThe implementation of new blood cooler inserts, tracking system, and educational initiatives substantially reduced the mean annual total RBC wastage. The cost to implement this initiative may be small if there is an existing institutional infrastructure to monitor and track hospital equipment into which the blood bank intervention can be adapted when compared to the cost of blood wastage.
Platelet storage performance is consistent by donor: a pilot study comparing “good” and “poor” storing platelets
Authors: Bontekoe Ido J. , van der Meer Pieter F. , van den Hurk Katja , Verhoeven Arthur J. , de Korte Dirk 
Published: July 2017

BACKGROUNDIn retrospective studies, it has been shown that differences in storage variables of platelet (PLT) concentrates (PCs) are partially donor dependent. It was our aim to prospectively determine the donor effect on PLT quality.STUDY DESIGN AND METHODSBased on quality control data of outdated apheresis PCs, male donors were selected with at least one PC with a pH value of more than 7.0 (“good,” n = 6) or one PC with a pH value of less than 6.7 (“poor,” n = 6) on Day 8. These donors donated a PC (Trima Accel, Terumo) and completed a short questionnaire about their health and lifestyle. PCs were stored for 12 days and analyzed at regular intervals for in vitro quality.RESULTSDonor characteristics were comparable, except that zero of six good and four of six poor donors reported high blood pressure and/or high cholesterol/fat and/or use of medicines. Lactate production in good PCs was lower than that in poor PCs (0.09 ± 0.03 mmol/day/1011 PLTs vs. 0.13 ± 0.04 mmol/day/1011 PLTs, p < 0.05) resulting in a higher pH from Day 5 onward. At the end of storage, the good PCs showed lower CD62P expression, lower phosphatidylserine exposure, and higher mitochondrial membrane potential. PLT functional properties were only slightly different. Despite having lower pH, the poor PCs also fulfilled European Guidelines during 7‐day storage.CONCLUSIONPlatelet storage performance is consistent when donors are dichotomized as having good or poor storing PLTs. Metabolic differences are perhaps due to different functionality of the mitochondria. More research is needed to establish the underlying causes and the implications for donors and blood products.
Escherichia coli isolates from commercial chicken meat and eggs cause sepsis, meningitis and urinary tract infection in rodent models of human infections
Authors: Mellata M. , Johnson J. R. , Curtiss R. 
Published: July 2017

SummaryThe zoonotic potential of Escherichia coli from chicken‐source food products is important to define for public health purposes. Previously, genotypic and phenotypic screening of E. coli isolates from commercial chicken meat and shell eggs identified some E. coli strains that by molecular criteria resembled human‐source extraintestinal pathogenic E. coli (ExPEC). Here, to clarify the zoonotic risk of such chicken‐source E. coli, we compared selected E. coli isolates from chicken meat and eggs, stratified by molecularly defined ExPEC status, to human‐source ExPEC and to laboratory E. coli for virulence in rodent models of sepsis, meningitis and UTI, and evaluated whether specific bacterial characteristics predict experimental virulence. Multiple chicken‐source E. coli resembled human‐source ExPEC in their ability to cause one or multiple different ExPEC‐associated infections. Swimming ability corresponded with urovirulence, K1 capsule corresponded with ability to cause neonatal meningitis, and biofilm formation in urine corresponded with ability to cause sepsis. In contrast, molecularly defined ExPEC status and individual genotypic traits were uncorrelated with ability to cause sepsis, and neither complement sensitivity nor growth in human urine corresponded with virulence in any infection model. These findings establish that chicken‐derived food products contain E. coli strains that, in rodent models of multiple human‐associated ExPEC infections, are able to cause disease comparably to human‐source E. coli clinical isolates, which suggests that they may pose a significant food safety threat. Further study is needed to define the level of risk they pose to human health, which if appreciable would justify efforts to monitor for and reduce or eliminate them.
Effectiveness of neurofeedback therapy for anxiety and stress in adults living with a chronic illness: a systematic review protocol
Authors: Blaskovits Farriss , Tyerman Jane , Luctkar-Flude Marian 
Published: July 2017

Review question/objective:
The objective of this review is to systematically examine the effectiveness of neurofeedback therapy for managing anxiety and stress in adults living with a chronic illness.
The specific objectives are to identify which neurofeedback systems and/or protocols demonstrate effectiveness and determine the level of supporting evidence.
The review question is as follows: What is the effectiveness of neurofeedback therapy for managing anxiety and stress in an adult population aged 18 years of age or older living with a chronic illness?
Experiences of Scandinavian nurses in discussing sexuality with patients, clients and residents: a qualitative systematic review protocol
Authors: Laursen Birgitte Schantz , Rasmussen Philippa , Conroy Tiffany 
Published: July 2017

Review question/objective:
: The objective of this review is to critically appraise, synthesize, and present the best available evidence to address the question: How do Scandinavian nurses experience discussing sexual issues with patients, residents and clients?
Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review protocol
Authors: Quinn Lori , Busse Monica , Carrier Judith , Fritz Nora , Harden Jane , Hartel Lynda , Kegelmeyer Deb , Kloos Anne , Rao Ashwini 
Published: July 2017

Review question/objective:
: The review seeks to evaluate the effectiveness of physical therapy and exercise interventions in Huntington's disease (HD). The review question is: What is the effectiveness of physiotherapy and therapeutic exercise interventions in people with HD, and what are patients’, families’ and caregivers’ perceptions of these interventions?
The specific objectives are:To determine the effectiveness of physiotherapy and therapeutic exercise interventions in people with HD on physical and cognitive function.To explore the perceptions of people with HD and their families and caregivers with regard to their experience of physiotherapy and exercise interventions.

This mixed methods review seeks to develop an aggregated synthesis of quantitative, qualitative and narrative systematic reviews on physiotherapy and exercise interventions in HD, in an attempt to derive conclusions and recommendations useful for clinical practice and policy decision-making.