bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermodynamic enantioseparation behavior of phenylthiohydantoin‐amino acid derivatives in supercritical fluid chromatography on polysaccharide chiral stationary phases
Authors: Khater Syame , Canault Baptiste , Azzimani Taoufik , Bonnet Pascal , West Caroline 
Published: December 2017

AbstractThirteen pairs of enantiomers belonging to the same structural family (phenylthiohydantoin‐amino acids) were analyzed on two polysaccharide chiral stationary phases, namely, tris‐(3,5‐dimethylphenylcarbamate) of amylose (Chiralpak AD‐H) or cellulose (Chiralcel OD‐H) in supercritical fluid chromatography with a carbon dioxide/methanol mobile phase (90:10 v/v). Five different temperatures (5, 10, 20, 30, 40°C) were applied to evaluate the thermodynamic behavior of these enantioseparations. On the cellulose stationary phase, the retention, and separation trends were most similar among the set of probe analytes, suggesting that the chiral cavities in this stationary phase have little diversity, or that all analytes accessed the same cavities. Conversely, the retention and separation trends on the amylose phase were much more diverse, and could be related to structural differences among the set of probe analytes (carbon chain length in the amino acid residue, secondary amine in proline, existence of covalent rings, or formation of pseudo‐rings via intramolecular hydrogen bonds). The large variability of behaviors on the amylose phase suggests that the chiral‐binding sites in this chiral stationary phase have more variety than on the cellulose phase, and that the analytes did access different cavities.
Polish globalization of Polish group partial actions
Authors: Pinedo Hector , Uzcátegui Carlos 
Published: December 2017

AbstractLet be a separable metrizable space. We establish a criteria for the existence of a metrizable globalization for a given continuous partial action of a separable metrizable group G on . If G and are Polish spaces, we show that the globalization is also a Polish space. We also show the existence of an universal globalization for partial actions of Polish groups.
Supramolecular Polymers Based on Non‐Coplanar AAA‐DDD Hydrogen‐Bonded Complexes
Authors: Mendez Iamnica J. Linares , Wang Hong‐Bo , Yuan Ying‐Xue , Wisner James A. 
Published: December 2017

AbstractNon‐coplanar triple‐hydrogen‐bond arrays are connected as telechelic groups to alkyl chains and their properties as AA/BB type supramolecular polymers are examined. Viscosity studies at three temperatures are used to study the ring‐chain equilibrium and determine the critical concentrations where polymer chains are formed. It is observed that neither the temperature range studied nor the alkyl chain length of one component significantly affect the polymerization properties in this system.
Synthesis and Biological Evaluation of a Degradable Trehalose Glycopolymer Prepared by RAFT Polymerization
Authors: Lau Uland Y. , Pelegri‐O'Day Emma M. , Maynard Heather D. 
Published: December 2017

AbstractThere is a significant need for new biodegradable protein stabilizing polymers. Herein, the synthesis of a polymer with trehalose side chains and hydrolytically degradable backbone esters and its evaluation for protein stabilization and cytotoxicity are described. Specifically, an alkene‐containing parent polymer is synthesized by reversible addition–fragmentation chain transfer polymerization, and thiolated trehalose is installed using a radical‐initiated thiol–ene reaction. The stabilizing properties of the polymer are investigated by thermally stressing granulocyte colony‐stimulating factor (G‐CSF), which is expressed and purified using a custom‐designed G‐CSF fusion protein with a polyhistidine‐tagged maltose binding protein. The degradable polymer is shown to stabilize G‐CSF to 66% after heating at 40 °C. Poly(5,6‐benzo‐2‐methylene‐1,3‐dioxepane (BMDO)‐co‐butyl methacrylate‐trehalose) is degraded and its cellular compatibility is investigated. While the polymer is noncytotoxic, cytotoxic effects are observed from the degraded products in fibroblasts and murine myeloblasts. These data provide important information for future use of BMDO‐containing trehalose glycopolymers for biomedical applications.
Hyperbranched Aliphatic Polyester via Cross‐Metathesis Polymerization: Synthesis and Postpolymerization Modification
Authors: Zeng Fu‐Rong , Ma Ji‐Mei , Sun Lin‐Hao , Zeng Zhen , Jiang Hong , Li Zi‐Long 
Published: December 2017

AbstractA novel postpolymerization modification methodology is demonstrated to achieve selective functionalization of hyperbranched polymer (HBP). Terminal and internal acrylates of HBP derived from cross‐metathesis polymerization (CMP) are functionalized in a chemoselective fashion using the thiol‐Michael chemistries. Model reactions between different thiols (benzyl mercaptan and methyl thioglycolate) and acrylates (n‐hexyl acrylate and ethyl trans‐2‐decenoate) by using dimethylphenylphosphine or amylamine as the catalyst are investigated to optimize the modification protocol for HBP. High‐molecular‐weight HBP P0 is generated through CMP of AB2 monomer 2, a compound containing one α‐olefin and two acrylate metathetically polymerizable groups. CMP kinetics is monitored by NMR and gel permeation chromatography (GPC). Accordingly, microstructural analysis is conducted in detail, and CMP procedure is optimized. Postpolymerization modification of HBP P0 is performed via two distinguished strategies, namely one‐step complete modification and sequential modification, to generate terminally and/or internally functionalized HBPs P1–P3 in a chemoselective fashion by using phosphine‐initiated and/or base‐catalyzed thiol‐Michael chemistries. Finally, thermal stability and glass transition behaviors of HBPs P0–P3 are studied by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC), respectively.
Multitemperature Responsive Self‐Folding Soft Biomimetic Structures
Authors: Kobayashi Kunihiko , Oh Seung Hyun , Yoon ChangKyu , Gracias David H. 
Published: December 2017

AbstractUntethered, millimeter‐scale, stimuli‐responsive shape change structures are critical to the function of autonomous devices, smart materials, and soft robotics. Temperature in a range compatible with physiological or ambient environmental conditions is an excellent cue to trigger actuation of soft structures for practical biomimetic applications. Previously, a range of thermally responsive self‐folding soft structures has been described and utilized in a variety of applications from tissue engineering to minimally invasive surgery. In order to extend these concepts to more complex devices, thermally responsive bilayer structures composed of poly[oligo (ethylene glycol) methyl ether methacrylate] (POEGMA) gels that swell at three different temperatures are described. The lower critical solution temperature and volume transition temperature of POEGMA are tuned by varying the side chain length and the extent of copolymerization. The swelling properties of the POEGMA gels are characterized and a multilayer photopatterning process is described that is used to create soft biomimetic structures that change shape in a sequential manner while displaying multistate behaviors.
Layered metal(IV) phosphonate materials: Solid‐state 1H, 13C, 31P NMR spectra and NMR relaxation
Authors: Sheikh Javeed Ahmad , Bakhmutov Vladimir I. , Clearfield Abraham 
Published: December 2017

Multinuclear solid‐state NMR and powder X‐ray diffraction data collected for phosphonate materials Zr(O3PC6H4PO3) · 3.6H2O and Sn(O3PC6H4PO3)0.85(O3POH)0.30 · 3.09H2O have resulted in the layered structure, where the phosphonic acids cross‐link the layers. The main structural motif (the 111 connectivity in the PO3 group) has been established by determination of chemical shift anisotropy parameters for phosphorus nuclei in the phosphonate groups. An analysis of the variable‐temperature 31P T1 measurements and the shapes of the phosphorus resonances in the 31P static NMR spectra have resulted in the dipolar mechanism of the phosphorus spin‐lattice relaxation, where the rotating phenylene rings reorient dipolar vectors P…H as a driving force of the relaxation process. It has been found that water protons do not affect the 31P T1 times. The activation energy of the phenylene rotation in both compounds has been determined as low as 12.5 kJ/mol. The interpretation of the phosphorus relaxation data has been independently confirmed by the measurements of 1H T1 times for protons of the phenylene rings.
Kinetics of Bulk Free‐Radical Polymerization of Butyl Methacrylate Isomers Studied by Reaction Calorimetry
Authors: Victoria‐Valenzuela David , Herrera‐Ordonez Jorge , Arcos‐Casarrubias Antonio , Vazquez‐Torres Humberto 
Published: December 2017

AbstractThe kinetics of bulk free‐radical polymerizations of n‐butyl methacrylate (n‐BMA), iso‐butyl methacrylate (i‐BMA), and tert‐butyl methacrylate (t‐BMA) are studied by differential scanning calorimetry and with the aid of a mathematical model previously reported by the authors. In all the cases, the rate of polymerization (Rp) evolution curve exhibits a minimum at low conversions and the characteristic maximum of the autoacceleration effect. It is found that the monomer conversion xmin at which the minimum is observed, follows the order n‐BMA > i‐BMA > t‐BMA and that for monomer conversions (x) smaller than xmin, the termination rate coefficient (kt) shows a plateau. According to the model results it is obtained that for x > xmin, the termination reaction is chemically controlled whereas for x > xmin, it is diffusion‐controlled and that the xmin values are related to the value of the termination rate coefficient of the chemical step (kt0) of every isomer, which is highly influenced by the steric hindrance of the alkyl substituent group.
Simultaneous bilateral‐knee MR imaging
Authors: Kogan Feliks , Levine Evan , Chaudhari Akshay S. , Monu Uchechukwuka D. , Epperson Kevin , Oei Edwin H.G. , Gold Garry E. , Hargreaves Brian A. 
Published: December 2017

PurposeTo demonstrate and evaluate the scan time and quantitative accuracy of simultaneous bilateral‐knee imaging compared with single‐knee acquisitions.MethodsHardware modifications and safety testing was performed to enable MR imaging with two 16‐channel flexible coil arrays. Noise covariance and sensitivity‐encoding g‐factor maps for the dual‐coil‐array configuration were computed to evaluate coil cross‐talk and noise amplification. Ten healthy volunteers were imaged on a 3T MRI scanner with both dual‐coil‐array bilateral‐knee and single‐coil‐array single‐knee configurations. Two experienced musculoskeletal radiologists compared the relative image quality between blinded image pairs acquired with each configuration. Differences in T2 relaxation time measurements between dual‐coil‐array and single‐coil‐array acquisitions were compared with the standard repeatability of single‐coil‐array measurements using a Bland‐Altman analysis.ResultsThe mean g‐factors for the dual‐coil‐array configuration were low for accelerations up to 6 in the right–left direction, and minimal cross‐talk was observed between the two coil arrays. Image quality ratings of various joint tissues showed no difference in 89% (95% confidence interval: 85–93%) of rated image pairs, with only small differences (“slightly better” or “slightly worse”) in image quality observed. The T2 relaxation time measurements between the dual‐coil‐array configuration and the single‐coil configuration showed similar limits of agreement and concordance correlation coefficients (limits of agreement: −0.93 to 1.99 ms; CCC: 0.97 (95% confidence interval: 0.96–0.98)), to the repeatability of single‐coil‐array measurements (limits of agreement: −2.07 to 1.96 ms; CCC: 0.97 (95% confidence interval: 0.95–0.98)).ConclusionA bilateral coil‐array setup can image both knees simultaneously in similar scan times as conventional unilateral knee scans, with comparable image quality and quantitative accuracy. This has the potential to improve the value of MRI knee evaluations. Magn Reson Med 80:529–537, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
High‐performance direct algorithms for computing the sign function of triangular matrices
Authors: Stotland Vadim , Schwartz Oded , Toledo Sivan 
Published: December 2017

SummaryAlgorithms and implementations for computing the sign function of a triangular matrix are fundamental building blocks for computing the sign of arbitrary square real or complex matrices. We present novel recursive and cache‐efficient algorithms that are based on Higham's stabilized specialization of Parlett's substitution algorithm for computing the sign of a triangular matrix. We show that the new recursive algorithms are asymptotically optimal in terms of the number of cache misses that they generate. One algorithm that we present performs more arithmetic than the nonrecursive version, but this allows it to benefit from calling highly optimized matrix multiplication routines; the other performs the same number of operations as the nonrecursive version, suing custom computational kernels instead. We present implementations of both, as well as a cache‐efficient implementation of a block version of Parlett's algorithm. Our experiments demonstrate that the blocked and recursive versions are much faster than the previous algorithms and that the inertia strongly influences their relative performance, as predicted by our analysis.
Recovery of strong equilibrium from displacement‐based finite element models of Reissner‐Mindlin plates
Authors: Maunder E. A. W. , Moitinho de Almeida J. P. 
Published: December 2017

SummaryIn this paper, we extend to Reissner‐Mindlin plate bending problems a technique, originally proposed in the context of two‐dimensional and three‐dimensional continua, for recovering fully equilibrated stresses from the solution of a compatible finite element model. The technique involves partition of unity functions and the analyses of overlapping star patches modelled with hybrid equilibrium plate elements. The patches are subjected to balanced systems of loads composed of partitioned and fictitious loads, where the latter are derived from the stresses of the compatible solution. The special case of assumed linear displacement fields of both deflection and rotation for the compatible model is included. This case requires additional fields of stress resultants to correct possible rotational imbalances of star patches, and these are derived elementwise. Other cases of nonconforming elements are briefly considered. Numerical examples are presented to illustrate the effectiveness of these techniques in terms of the deviation of the recovery, which compares the complementary strain energy of a recovered solution with that obtained by a global equilibrated analysis based on the same stress approximations.
Some effects of foaming of the poly(butylene adipate‐co‐terephthalate) modified by electron radiation
Authors: Malinowski Rafał , Stepczyńska Magdalena , Raszkowska‐Kaczor Aneta , Żuk Tomasz 
Published: December 2017

Investigation of the effect of electron radiation and foaming agent on some properties of poly(butylene adipate‐co‐terephthalate) (PBAT) was the aim of the present paper. The mass flow rate, weight‐average molecular weight of irradiated PBAT as well as the morphological structure of foamed samples, their density, tensile strength, and specific strength were determined. It was found that irradiation of PBAT induces growth in weight‐average molecular weight and decrease in mass flow rate, and as a consequence of this increase in viscosity of this polymer. It was also found that foaming of irradiated PBAT causes formation of homogeneous cellular structure or structure with a clear separation of large and small cells. Simultaneously, the irradiated and foamed PBAT shows smaller density than that of non‐irradiated and foamed PBAT. Moreover, electron radiation does not influence tensile strength of the foamed PBAT; however, it increases its specific strength, although only if the content of foaming agent is 1 wt%.
Hybrid factors influencing wet grip and rolling resistance properties of solution styrene‐butadiene rubber composites
Authors: Choi Sung‐Seen , Kwon Hyuk‐Min , Kim Yeowool , Ko Eunah , Lee Ki‐Suk 
Published: December 2017

AbstractInfluencing factors on wet grip and rolling resistance properties of solution styrene − butadiene rubber (SBR) composites were investigated in terms of main hybrid components of the microstructure and crosslink density. Influence of the molecular weight and oil extension on the wet grip and rolling resistance properties was also examined. The styrene and 1,2‐unit contents of SBR affected the wet grip and rolling resistance properties. The influence of hybrid factors on the wet grip and rolling resistance properties was examined using 3D plots of the microstructure and crosslink density. The wet grip property was influenced by the hybrid microstructure of the styrene and 1,2‐unit as well as the crosslink density. The rolling resistance property was found to be mainly affected by not only the styrene content but also the crosslink density. It was found that SBR with appropriate styrene content (15 − 18 mol%), relatively high 1,2‐unit content (45 − 50 mol%) and relatively high crosslink density (over 1.5 × 10−4 mol cm−3) might be good for improvement of both the wet grip and rolling resistance properties. © 2017 Society of Chemical Industry
SIMLR: A Tool for Large‐Scale Genomic Analyses by Multi‐Kernel Learning
Authors: Wang Bo , Ramazzotti Daniele , De Sano Luca , Zhu Junjie , Pierson Emma , Batzoglou Serafim 
Published: December 2017

AbstractSIMLR (Single‐cell Interpretation via Multi‐kernel LeaRning), an open‐source tool that implements a novel framework to learn a sample‐to‐sample similarity measure from expression data observed for heterogenous samples, is presented here. SIMLR can be effectively used to perform tasks such as dimension reduction, clustering, and visualization of heterogeneous populations of samples. SIMLR was benchmarked against state‐of‐the‐art methods for these three tasks on several public datasets, showing it to be scalable and capable of greatly improving clustering performance, as well as providing valuable insights by making the data more interpretable via better a visualization. SIMLR is available on https://github.com/BatzoglouLabSU/SIMLRGitHub in both R and MATLAB implementations. Furthermore, it is also available as an R package on http://bioconductor.org
Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV‐Induced Innate Immunity
Authors: Shang Jun , Xia Tian , Han Qiang‐Qiang , Zhao Xiaolu , Hu Ming‐Ming , Shu Hong‐Bing , Guo Lin 
Published: December 2017

AbstractTBK1, STING, and MDA5 are important players within the antiviral innate immune response network. We mapped the interactome of endogenous TBK1, STING, and MDA5 by affinity enrichment MS in virally infected or uninfected THP‐1 cells. Based on quantitative data of more than 2000 proteins and stringent statistical analysis, 58 proteins were identified as high‐confidence interactors for at least one of three bait proteins. Our data indicated that TBK1 and MDA5 mostly interacted within preexisting protein networks, while STING interacted with different proteins with different viral infections. Functional analysis was performed on 17 interactors, and six were found to have functions in innate immune responses. We identified TTC4 as a TBK1 interactor and positive regulator of sendai virus‐induced innate immunity.
The effect of an attachment‐oriented couple intervention for breast cancer patients and partners in the early treatment phase: A randomised controlled trial
Authors: Nicolaisen A. , Hagedoorn M. , Hansen D.G. , Flyger H.L. , Christensen R. , Rottmann N. , Lunn P.B. , Terp H. , Soee K. , Johansen C. 
Published: December 2017

AbstractObjectivePatients and partners both cope individually and as a dyad with challenges related to a breast cancer diagnosis. The objective of this study was to evaluate the effect of a psychological attachment‐oriented couple intervention for breast cancer patients and partners in the early treatment phase.MethodsA randomised controlled trial including 198 recently diagnosed breast cancer patients and their partners. Couples were randomised to the Hand in Hand (HiH) intervention in addition to usual care or to usual care only. Self‐report assessments were conducted for both patients and partners at baseline, postintervention (5 months), and follow‐up (10 months), assessing cancer‐related distress, symptoms of anxiety and depression, and dyadic adjustment. Patients' cancer‐related distress was the primary outcome.ResultsCancer‐related distress decreased over time in both patients and partners, but the intervention did not significantly affect this decrease at postintervention (P = .08) or follow‐up (P = .71). A significant positive effect was found on dyadic adjustment at follow‐up for both patients (P = .04) and partners (P = .02).ConclusionsThere was no significant effect of the HiH intervention cancer‐related distress. The results suggest that most couples can cope with cancer‐related distress in the context of usual care. However, the positive effect on dyadic adjustment implies that the HiH intervention benefitted both patients and partners. Future studies should investigate how to integrate a couple focus in usual cancer care to improve dyadic coping in the early treatment phase.
Validation of the GLI‐2012 spirometry reference equations in Argentinian children
Authors: Busi Luciano E. , Sly Peter D. 
Published: December 2017

AbstractAimThe Global Lung Function Initiative (GLI) has produced spirometry reference equations for use in different ethnic groups. Previous reports have shown that the GLI equations do not adequately describe lung function in all populations and that adopting the new equations into clinical practice can increase the number of patients considered to have abnormal lung function. Therefore, before adopting these equations into local practice it is necessary to establish how well the equations represent the local population. The present study was conducted to determine how well the GLI spirometry reference equations represented the young children in Argentina, a population not included in the GLI dataset.MethodsSpirometry was measured in 2072 healthy children (50.9% males) aged 3.0‐12.4 years (mean 6.64 ± SD 1.39), with a height range of 93.0‐158.5 cm and weight range from 13.1 to 54.7 kg. We used the GLI “Caucasian” and “other/mixed” race equations to create Z‐scores.ResultsThe Z‐scores predicted by the Caucasian GLI equations did not differ from zero and fitted the data well. Z‐scores calculated using “other/mixed race” fit less well. Using the GLI definition of low lung function (Z‐score <1.65) 6.8% of our healthy population had abnormal FVC, 4.9% had abnormal FEV1, 5.9 % had abnormal FEV0.75, and 3.9% had abnormal FEF25‐75 when using the “Caucasian” GLI equation. This compares well with the expected 5% below the lower limit of normal.ConclusionWe recommend the use of the GLI‐2012 Caucasian equations for spirometry undertaken in Argentinian children.