bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Irritable Bowel Syndrome upon Female s' Health Related Quality of Life
Authors: Hassan Huda Baqer , Jadoow Batool Amin 
Published: October 2024

متلازمة القولون التهيجي هو من الحالات الشائعة الحدوث والمتصفه بالم في البطن مع الاسهال او الامساك. وتشير الاحصائيات ان نسبة حدوث المرض هي 1 من بين 1000 فرد مريض سنويا" ونسبة الاصابة تختلف مابين 4-13% ونسبة انتشار المرض من 6-20% وهذه الحالة المرضية كثيرة الانتشار بين النساء عنه عند الرجال ، وتحدث مابين الاعمار 15 و 65 مسببة" مضاعفات طويلة الامد. ان نسبة 15-20% من الاصابات عند النساء تكون مجهولة السبب ويعتقد البعض ان الاضطرابات الجسمية –النفسية قد تكون سبب في ظهور الحالة المرضية واشارت بعض الدراسات ان النشاطات المناعية في الجسم قد يكون عامل اخر في ظهور الحالة . لتهيج القولون العصبي تأثير كبير على الانسان من خلال استمرارية ظهور الاعراض وبشكل مزمن مما يؤثر ويعيق النشاطات والمهارات اليومية بالاضافة لتاثيرة على الوضع النفسي والعاطفي للفرد، لذا لابد من ايجاد وسائل مساعدة لمعالجة وايقاف هذه العلامات المستمرة ولكي يتكيف المريض مع حالته الصحية دون التاثير على حياته العامة.
دراسة وصفية تحليلية بدأ العمل بها مابين 8تموز 2008 ولغاية 29 من تشرين الاول 2009 للتعرف على تاثير تهيج القولون العصبي على نوعية حياة النساء.
اجريت الدراسة الحالية في مستشفى امراض الجهاز الهضمي والكبد في بغداد.عينة غرضية اجريت على 100 مريضة مصابة بتهيج القولون العصبي. تكونت أداة الدراسة من جزئين مع صفحة الترحيب بالمشاركين في الدراسة
الجزء الاول: المعلومات اليموغرافية للمريض.
الجزء الثاني:تم استعمال المقياس العالمي المتضمن 36فقرة الذي يتعلق بقياس نوعية الحياة الصادر من منظمة الصحة العالمية والمتضمن المحاور التالية ( الوضع الصحي، الوظائف الجسمية، الدور الوظيفي، الدور العاطفي، الوظيفة الاجتماعية، الالم الجسمي، الفعاليات، الصحة العقلية، الصحة العامـة).
اظهرت نتائج الدراسة ل(100) امراة مصابة بتهيج القولون العصبي ان 30%من النساء هن من الفئات العمرية (28-37) سنة و 54% منهن متزوجات ومستمرة حياتهم الزوجية ومعظم المصابات هن موظفات (61%) وغالبية المصابات هن خريجات جامعيات (42%) واظهرت الدراسة ان نصف العينة من ذوات الدخل العالي ونسبة 47% من المصابات هن من النوع المتناوب بين الامساك والاسهال لتهيج القولون وكان الدور الجسمي والدور العاطفي قد حصل على اقل متوسط حسابي عن المحاور الاخرى لمقياس نوعية الحياة.
توصلت الدراسة ان لتهيج القولون العصبي تاثير سلبي على نوعية حياة النساء اللواتي ضمن الفئات العمرية( 28-37) وعلى النساء المطلقات والنساء الموظفات في المؤسسات الحكومية.
Mating Competitiveness and Flight Ability of Sterile Males of Cucurbits Fruit Fly Dacus ciliatus ((Loew)(Diptera:Tefritidae)
Authors: Alrubeai Hussain . F. , Yousif George. S. B. , AL-Azzawi Bader. A. , Hamad Bassim. Sh. 
Published: October 2024

أظهرت نتائج دراسة مستوى التنافس ألتزاوجي للذكور البازغة من عذارى مشععة بعمر 7 أيام بالجرعة الإشعاعية 100 غري أنها كانت ذات قابلية تزاوج جيدة عند إطلاقها مع ذكور وإناث غير مشععة بالنسبتين 3 :1 :1 و 5: 1 : 1 وذات قابلية عالية بالنسبتين 7 :1 :1 و9 : 1 :1 ( ذكور مشععة : ذكور غير مشععة : إناث غير مشععة ). أما الذكور البازغة من عذارى مشععة بالجرعة 120 غري فكانت ذات قابلية تنافس جيدة في النسبتين 7 :1 :1 و 9 :1 :1 .
وفي دراسة قابلية الطيران للحشرات المشععة أظهرت النتائج عدم تأثير الإشعاع على مؤشر قابلية الطيران للحشرات البازغة من عذارى مشععة بعمر 7 أيام بالجرع الإشعاعية 80 و100 و120 غري لكنها انخفضت معنويا عند الجرعة 200 غري .
Measuring the effect of cell mismatch on PSPICE module model output
Authors: Kubba Zainab M. 
Published: October 2024

يقدم هذا البحث طريقة نظرية لحساب عامل عدم التماثل (mismatch factor) باستخدام برنامج PSPICE . من خلال دراسة هذا العامل تمت ملاحظة تأثير عامل عدم التماثل في خواص اللوح الشمسي وكذلك قدرته. عمليا في هذه الدراسة تم استخدام موديل للوح يتكون من 36 خلية شمسية مربوطة على التوالي والمبني في برنامج PSPICEمن عمل سابق قامت به الباحثة. وبما ان تطبيقات اللوح الشمسي كافة تحتاج الى سلسلة من الالواح التي تربط على التوالي او التوازي لتحقيق التيار والفولتية المناسبة لذلك، تم فحص تأثير عدم التماثل في خلايا اللوح الشمسي عند ربطها على التوالي والتوازي ايضا. أثبتت الدراسة ان تأثير هذا العامل يختفي عند ربط الالواح على التوازي.
Relation between Body Iron Store and Insulin Resistance in Type 2 Diabetes
Authors: AL-Tai Wafa F. , Mohammed Inaam A. , Sabri Mayada S. 
Published: October 2024

تم التحري عن التداخلات السريرية لحالة الحديد في الجسم والتي تشمل (حديد مصل الدم والحديد المخزون في الفيريتين) عند مرضى داء السكري غير المعتمد على الانسولين(النوع 2 ) .
شملت الدراسة 36 انثى ، من الاناث 18 مصابة بداء السكري ( النوع 2) و 18 انثى من الاصحاء .
كانت المجموعتين متقاربتين بالعمر وفي مؤشر كتلة الجسم (BMI ).
اما مجموعة المريضات فقد كانت متماثلة فيما بينها من حيث العمر ومؤشر كتلة الجسم والعلاجات الفموية الخافضة للسكر(مثل الكلبنكلامايد والميتفورمين )ومضاعفات داء السكر.
تم قياس الدوال الكيموحيوية لمجموعتي الاصحاء والمرضى وقد شملت :- الانسولين, الكلوكوز بعد الصيام, الحديد في مصل الدم والفيريتين.
لوحظت زيادة معنوية عالية في جميع هذه الدوال عند المرضى مقارنة بالاصحاء. وقد كانت هذه الزيادة واضحة في مقاومة الانسولين (IR ) والتي تم حسابها حسب المعادلة :-

IR = (الانسولين µIU/ ml × الكلوكوز mmol/ L) / 22.5

حيث وجدت (275.9 ± 22.7 ) مقارنة بالاصحاء (41.5 ± 11.3 )
Scheduling Job Families on a Single Machine
Authors: Mahmood Adawiyah A. , Saheab Naji  M. 
Published: October 2024

إن هــــــــذا البحث يتناول دراسة n من النتاجات ( jobs) على ماكنة واحدة بحيــــــــــث أن هذه النتاجات مقسمة إلى F من العوائل (Families ) ، كل عائــــــــلة ( f=1 , ………, F) تحتوي على nf من النتاجات ، الهدف من هذه الدراسة هو إيجاد قيد ادنى لمسألة تصغير دالـــــــــة الهدف المركبة وهي مجمـــــــــوع أوقات الإتمام وأعظم تأخيــــر لاســــــالب (The sum of completetion times and the maximum tardiness) .
في هذا البحث يتم إيجاد قيد أدنى ( Lower bound ) لغرض استخدامه في خوارزمية التقيد والتفرع للحصول على الجدول الأمثل .
Novel Artificial Lift Technology Improves Marginal Field Economics-A Case Study
Authors: DuBois S. , Aldridge D. , Sommese G. 
Published: October 2024

Abstract
As an oilfield matures, the economics of continuing production are heavily influenced by the day-to-day lease operating expenses (LOEs). One major component of LOEs can be the artificial lift. The objectives of this case study were to evaluate the economic improvement of a brownfield utilizing an innovative artificial lift system. Results are compared to the previous use of rod lift technology. Additionally, features and benefits of the system for broader applications are discussed in detail.
The artificial lift method examined in this paper involves replacement of existing artificial lift systems, typically rod lift, as is the case in this application. This case study highlights the experiences of the Operator of mature properties that removed rod lift equipment and replaced it with the novel pneumatic technology throughout the field. It highlights the tangible economic benefits of the conversion and discusses additional applications of the system in shallow well environments.
This paper first presents a brief history of the field development, setting the stage of the environmental challenges for the application of any recovery system. Research of product performance and its applicability to the subject field was followed by field visits to another Operator's location utilizing the technology. It documents the three-step field test and deployment program, that covers a span of four years: initial installation of seven wells, two more installations over the next year and finally a complete changeover of every producing well under management of the Operator. The expectation that the change of technology would reduce lease operating expenses was met and is quantified in the paper. Inherent issues associated with rod lift and tubing were eliminated (i.e., tubing holes due to corrosion, packing changes and pump failures) leading to additional production days per year. Furthermore, electricity costs have been reduced due to the self-regulation of the new pumps and centralization of the power supply. These ancillary benefits will also be illustrated.
The case study presented in this paper will benefit engineers and technicians who wish to extend the life of their assets by reducing the costs associated with their existing artificial lift. This is accomplished by replacing what is perhaps the most common method of artificial lift utilized for initial, secondary and tertiary recovery, with a field proven novel system. Furthermore, the paper will highlight the environmentally friendly features of the system that align with the growing focus on, and concerns with, ESG by eliminating methane emissions.
Novel Re-Crosslinkable Preformed Particle Gels (RPPG) for Parent- and Infill-Well-Fracture Interactions Mitigation
Authors: Ge Xiaojing , Alotibi Adel , Al-Hlaichi Ahmed , Liu Yanbo , Song Tao , Liu Junchen , Bai Baojun , Schuman Thomas 
Published: October 2024

AbstractHydraulic fracturing treatments in unconventional infill (or "child") wells can be significantly affected by depletion from existing parent-well, resulting in asymmetrical fracture growth. These issues may lead to excessive load-water production, proppant deposition, casing deformation in the parent well, and unbalanced stimulation of infill wells. To mitigate these effects, various strategies have been proposed, including the use of far-field diverters in child wells and repressurization of parent wells. Additionally, an increasingly popular strategy involves injecting near-wellbore diverters to temporarily plug entry points into the parent wellbores during frac operations on infill wells. To achieve better application, a novel low-cost, self-degradable, re-crosslinkable preformed particle gel (RPPG) has been developed and evaluated. Preliminary characterization results indicate that this RPPG exhibits sufficient thermal stability and self-degrading performance at 150°C during the required timeframe, with minimal residues. It also demonstrates good injectivity and plugging efficiency.
A novel lncRNA AC112721.1 promotes the progress of triple-negative breast cancer by directly binding to THBS1 and regulating the miR-491-5p/C2CD2L axis
Authors: sheng Miaomiao , Ma Ping , Kang Shiyao , Li Huimin , Li Ming , zhao Yuan , Yuan Hongjun , Pang Jianyu , Tang Wenru 
Published: October 2024

Abstract

Triple-negative breast cancer (TNBC) seriously threatens women's health, long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in TNBC. This study aims to explore lncRNAs that can provide effective targets for the early diagnosis or treatment of TNBC. Here, we utilized the TCGA database to analyze differentially expressed genes, survival analysis and ROC curve analysis were also carried out. Notably, we identified a novel lncRNA, AC112721.1, which was significantly overexpressed in TNBC and associated with poor overall survival of TNBC patients. The loss and gain-of functional experiments revealed that AC112721.1 significantly promoted cells proliferation, migration, and suppressed cell apoptosis in vitro and inhibited tumorigenesis in vivo. Further study of underlying mechanisms demonstrated that AC112721.1 regulated the Ras pathway by directly binding to THBS1 protein and also functioned as ceRNA by sponging miR-491-5p to increase the expression of C2CD2L, thereby influencing the progression of TNBC. Taken together, our study indicated that AC112721.1 might be a new biomarker for the evaluation of TNBC prognosis and the treatment of TNBC.
All hard X-ray transient grating spectroscopy
Authors: Ferrari Eugenio , Ueda Hiroki , Fainozzi Danny , Osaka Taito , Bencivenga Filippo , Burian Max , Carrara Pietro , Vila-Comamala Joan , Cucini Riccardo , David Christian , Gessini Alessandro , Gerber Simon , Goloborodko Andrii , Hrabec Aleš , Inoue Ichiro , Inubushi Yuichi , Leroy Ludmila Diniz , Roesner Benedikt , Rouxel Jérémy , Serrat Carles , Scagnoli Valerio , Tono Kensuke , Yabashi Makina , Yamada Jumpei , Yamamoto Kohei , Zdora Marie , Beye Martin , Mincigrucci Riccardo , Paris Eugenio , Pedrini Bill , Masciovecchio Claudio , Chergui Majed , Staub Urs , Svetina Cristian 
Published: October 2024

Abstract

A microscopic understanding of matter requires the study of excitations across an extended spatial, time and frequency range. The tens of nanometer lengthscale is crucial for transport phenomena in liquids and crystals. It holds the key to understanding phenomena such as charge, spin and heat diffusion at the frontier of diffusive and ballistic regimes. At the nanometer scale, disorder, diffusion, and relevant physical phenomena deviate from classical descriptions. It also covers the dynamics of charge/spin ordering and of the lattice. Opticaldomain transient gratings (TG) spectroscopy demonstrated access to all relevant degrees of freedom (e.g. charge, lattice, orbital and spin) of matter, but are limited to typically micron-size grating periods. Extreme-Ultraviolet TG spectroscopy has represented a major leap forward as it allowed access to mesoscopic scales. 1–4 Using hard X-rays for excitation and probing can extend TG spectroscopy beyond the aforementioned length scales. While hard X-ray generated TGs and their probing by optical pulses were recently reported, 5,6 here we present an X-ray TG (XTG) study, in which few-femtosecond hard X-ray pulses are used both for excitation and probing. Our study establishes key ingredients that allow previously inaccessible length (and therefore, momentum) regions. Ultrafast all X-ray TG thus emerges as a complementary approach to methods, such as inelastic neutron7 and X-ray8 scattering techniques, that are commonly used in the study of microscopic transport phenomena.
Gait Characteristics in Stroke Patients with Vestibular Symptoms Under Different Walking Speed Conditions
Authors: Yin Miaomiao , Li Yaqing , Cui Liling , Wang Fei , Chen Junying , Zhang Yue 
Published: October 2024

Abstract

Objective
To investigate the gait kinematic parameters of stroke patients with vestibular symptoms at different walking speeds.
Methods
Thirty-eight patients with brainstem stroke hospitalized in Tianjin Huanhu Hospital from June 2022 to June 2023 were included, along with 30 control subjects matched in gender, age, and education level. The walking stability was evaluated by 7⁃Meter walking test, and the differences in gait parameters were analyzed under conditions of fast, self-selected, and slow walking speeds.
Results
Under the fast-walking conditions, there were no statistically significant differences in the spatial gait parameters of step speed and stride length between the two groups (P > 0.05). However, there was a statistically significant difference in the percentage of double support time, a temporal parameter (P < 0.05). No significant differences were found in the percentage of terminal double support, stride frequency, and stride duration (P > 0.05). Under the self-selected and slow walking conditions, except for stride frequency and step duration, all other gait parameters showed statistically significant differences between the two groups (all P < 0.05). Specifically, in the group with vestibular symptoms, their spatial gait parameters of stride length and step speed were lower than those in the control group (both P = 0.000), while the percentage of terminal double support and double support time were higher than the control group (P < 0.01).
Conclusion
Walking speed significantly influences the gait parameters of stroke patients with vestibular symptoms, particularly under slow and self-selected walking speeds. This provides important clinical value for the implementation of precision rehabilitation treatment.
Evaluation of the Applicability of an Artificial Intelligence System for Mammography Analysis Trained on Overseas Data for Japanese Domestic Data
Authors: Makita Maya , Murakami Kouzou , Murakami Wakana , Takamatsu Hiroko , Kanai Takahiro , Sekimoto Atsuhito , Ito Yoshinori , Ohgiya Yoshimitsu 
Published: October 2024

Abstract

This study evaluated the performance of the Artificial Intelligence (AI)-based Computer-Aided Diagnosis system (AI-CAD), Lunit INSIGHT MMG, in detecting breast cancer from digital mammography images of Japanese women. We collected digital mammography images from two groups at Showa University Hospital. One group consisted of surgical and biopsy specimens of breast lesions between January and December 2019, and the other was digital mammography images taken at Showa University Hospital during the same period. The AI-CAD system was developed based on a convolutional neural network trained on over 200,000 cases, overseas of Japan. We analyzed the breast cancer detection capabilities and compared the results with the interpretations of the radiologists and breast surgeons. We used the area under the receiver operating characteristic (AUROC) curve to evaluate the data. We evaluated the performance of the Lunit INSIGHT MMG using a dataset of 676 breasts from 338 patients. Although no significant overall difference was observed, the radiologists reported increased sensitivity, specificity, and AUROC values, on average. The AI-CAD system trained on overseas data showed comparable effectiveness with Japanese data.
Utilizing Fetal MRI and Prenatal Medical Exome Sequencing for Prenatal Diagnosis of Kinked Brainstem: A Case Series
Authors: Wang Yunan , Liu Chang , Liu Ling , Yang Chaoxiang , Huang Yanlin , Geng Juan , Qi YiMing , Zhao Xin , Xiong Ying , Fang Liyuan , Wu Jing , Yin Aihua 
Published: October 2024

Abstract

Objective
Utilizing fetal MRI and prenatal Medical Exome Sequencing (pMES) for prenatal diagnosis in fetuses exhibiting a kinked or 'z-shaped' brainstem.
Methods
A retrospective analysis was conducted on cases of brainstem kinking identified on antenatal imaging between January 2013 and December 2022. Systematic review was performed on clinical data from these cases, encompassing maternal demographics, indications for invasive prenatal diagnosis, ultrasound findings, SNP-array results, trio-medical exome sequencing (Trio-MES) results, pregnancy outcomes and follow-ups.
Results
Two cases of fetuses presenting with a "kinked brainstem," along with other CNS abnormalities in fetal MRI were identified using Trio pMES. Prenatal phenotype features observed in our case series include "Z" shaped brainstem, hydrocephalus, hyperechogenic kidneys and generalized skin edema, cobblestone lissencephaly, cerebellar dysplasia, cerebral arachnoid cyst. Trio pMES identified a homozygous variant at c.815_816del (p.Leu272ArgfsTer117) in the FKRP gene for Patient 1. For Patient 2, a de novo heterozygous variant c.848A > G(p.H283R) was detected in the TUBA1A gene. Both variants were predicted to be likely pathogenic or pathogenic.
Conclusion
A kinked or "z-shaped" brainstem is a finding that can be more easily delineated on fetal MRI compared to fetal ultrasound, indicating an underlying dystroglycanopathy (Walker-Warburg phenotype) or tubulinopathy. Prenatal exome sequencing can aid in achieving early prenatal genetic diagnosis for cases of "kinked brainstem". Moreover, our study expands its scope by incorporating additional features such as hyperechogenic kidneys and generalized skin edema into the prenatal findings of Walker-Warburg syndrome.
Mitigating Energy Holes and Enhancing QoS in Delay Tolerant Networks: The EEEHR-M Protocol
Authors: KARUPPIAH LAKSHMI PRABHA , CHENGUTTUVAN EZHILAZHAGAN 
Published: October 2024

Abstract

Networks with limited resources, known as delay-tolerant networks (DTNs), experience data loss as a result of node energy depletion and reduced network lifetime. To tackle these problems, the Energy Efficient Energy Hole Repelling Protocol for Mobile Nodes in Delay Tolerant Networks (EEEHR-M) is being developed. In this procedure, clusters are created, and the distance from the sink and leftover energy are used to determine the Cluster Head (CH). These CHs facilitate communication between adjacent clusters. The sink's location and the energy levels of the cluster's nodes are taken into account during cluster creation, the reduction of Cluster Members (CMs), and the optimal Cluster Head (CH) selection. An innovative remedy for the existing energy hole is provided by the suggested algorithm, EEEHR-M. The simulation results demonstrate an enhancement in the proposed routing protocol, Quality of Service (QoS) by 4%, with 8% less energy consumption and 6% less average latency when compared to other Epidemic, Optimal Energy Consumption Protocol (OECP), and Optimal Opportunistic Forwarding (OOF) protocols.
Development, optimization and application of a Universal Fluorescence Multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors
Authors: Zhang Meng , Yao Xingfeng , Zhang Nan , Yu Yongbo , Jia Chao , Guan Xiaoxing , Xu Wenjian , Ni Xin , Guo Yongli , He Lejian 
Published: October 2024

Abstract

Background
A number of genetic aberrations are associated with the BCL6-correpresor gene (BCOR), including internal tandem duplications (ITDs) and fusions (BCOR-CCNB3 and BCOR-MAML3), as well as YWHAE-NUTM2, which are found in clear cell sarcoma of the kidney (CCSK), sarcoma with BCOR genetic alterations, primitive myxoid mesenchymal tumor of infancy, and high-grade neuroepithelial tumors in children. Detecting these gene aberrations is crucial for tumor diagnosis. ITDs can be identified by targeted Sanger sequencing or agarose gel electrophoresis. However, gene fusions are usually detected through reverse transcription-polymerase chain reaction (RT-PCR) or fluorescence in situ hybridization. Methods that monitor these variants simultaneously in a sensitive and convenient manner are lacking in clinical practice.
Methods
This study validated a Universal Fluorescence Multiplex PCR-based assay that assessed BCOR ITDs, BCOR-CCNB3, BCOR-MAML3 and YWHAE-NUTM2 fusions simultaneously.
Results
The assay achieved a detection threshold of 10 copies for fusion genes and 0.3 ng genomic DNA for BCOR ITDs. The performance of this assay was also tested in a cohort of 43 pediatric tumors (17 undifferentiated small round cell sarcomas, and 26 tumors with a histological diagnosis of CCSK). In total, 20 BCOR ITDs, 4 BCOR-CCNB3 and one YWHAE-NUTM2 were detected. When compared with the final diagnosis, the assay achieved 93% sensitivity and 100% specificity.
Conclusions
Accordingly, this assay provided an effective and convenient method for detecting BCOR- and YWHAE-related abnormalities in tumors.
Prognosis of patients with Hodgkin lymphoma and indeterminate response to PD-1 inhibitor therapy: considerations for application of LYRIC criteria in real clinical practice
Authors: Fedorova Liudmila , Lepik Kirill , Gusak Artem , Kotselyabina Polina , Moiseev Ivan , Baykov Vadim , Mikhailova Natalia , Kulagin Alexander 
Published: October 2024

Abstract

PD-1 inhibitors have shown unconventional response patterns in classic Hodgkin lymphoma (cHL). These include the phenomenon of pseudoprogression, highlighting the need for specialized response criteria such as the LyRIC, which stringened definitions for disease progression with introduction of indeterminate response category. Despite their potential utility, these provisional criteria are currently underutilized and require further refinement through clinical practice data collection. In this retrospective study LyRIC criteria were systematically used for response assessments in 180 patients with refractory cHL treated with nivolumab. Median follow-up was 60 months. Indeterminate response (IR) was a frequent phenomenon in study population: at 3 months of therapy 63 (35%) patients had an indeterminate response (IR1 7%, IR2 23%, IR3 6%). Among them 18 (29%) achieved an objective response with continued monotherapy. There were no differences in OS or TTNT depending on the type of IR. IR was the best achieved response in 45 (25%) patients. Patients with IR had favorable prognosis with no difference in OS, PFS and TTNT comparing to patients with PR when subsequent therapy was initiated due to disease progression. Patients with IR may achieve prolonged disease control or a deeper response upon continuing treatment. These findings support the broader implementation and adjustment of LyRIC criteria in clinical practice to enhance decision-making in cHL patients treated with immunotherapy.