bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can We Differentiate Between Organic and Functional Bladder Outlet Obstruction in Males With Parkinson's Disease?
Authors: Vírseda‐Chamorro Miguel , Salinas‐Casado Jesús , Adot‐Zurbano José‐María , Méndez‐Rubio Santiago , Moreno‐Sierra Jesús 
Published: October 2024

ABSTRACTObjectivesTo determine the type of bladder outlet obstruction (BOO) in patients with Parkinson's disease (PD).Material and MethodA case–control study was carried out in 46 patients divided into two groups. Group 1 formed by 23 PD patients with BOO (a URA parameter ≥ 29 cm H2O). Group 2 formed by 23 patients with benign prostatic hyperplasia (BPH) and compressive obstruction (an opening pressure > 35 cm H2O) and URA parameter ≥ 29 cm H2O). Both groups underwent a pressure‐flow study to calculate Dynamic Urethral Resistance Relationship (DURR) patterns. Based on previous research, we describe two types of DURR pattern. Pattern A typical of dynamic or functional obstruction and pattern B typical of static or organic obstruction.ResultsWe found that PD patients had a significantly higher frequency of pattern A (70%) than BPH patients (4%). Other significant differences between groups were age (greater in PD group), bladder compliance (greater in PD group), maximum flow rate [Qmax (greater in BPH group)], maximum detrusor pressure [Pmax (greater in BPH group)], detrusor pressure at maximum flow rate [PQmax (greater in BPH group)], opening detrusor pressure (greater in BPH group), and the bladder contractility parameters BCI and Wmax (greater in BPH group). There were no significant differences in perineal voiding electromyography (EMG) activity between groups nor relationship between voiding EMG activity and the type of DURR pattern.ConclusionsOur results are consistent with the usefulness of the DURR pattern to differentiate between functional and organic BOO in PD patients. Most PD patients have functional obstruction although a minority has organic obstruction consistent with BPH.
New Ibuprofen Cystamine Salts With Improved Solubility and Anti‐Inflammatory Effect
Authors: Denizkusu Simay , Sabuncu Ece , Sipahi Hande , Avci Duygu 
Published: October 2024

AbstractTwo novel ibuprofen cystamine salts (IBU‐CYS 1 and IBU‐CYS 2) are synthesized by coupling the anion of ibuprofen with cystamine dihydrochloride in 1 : 1 and 2 : 1 ratio to improve the solubility and bioavailability of ibuprofen. The salts are characterized by 1H NMR, FT‐IR and UV‐Vis spectroscopy, differential scanning calorimetry (DSC), thermogravimetry (TGA, DTA) and X‐ray diffraction measurements. IBU‐CYS 1 and IBU‐CYS 2 show higher solubility (6.11 and 7.81 mg/mL) compared to ibuprofen (0.04 mg/mL) in water. IBU‐CYS2 was encapsulated into 2‐hydroxyethyl methacrylate: poly (ethylene glycol) acrylate hydrogels for enhanced delivery. The in vitro studies in PBS (pH 7.4) indicate that the salts are effective in relieving inflammatory responses induced by lipopolysaccharide in RAW264.7 macrophage cells (nitrite inhibition percentages of IBU‐CYS 1, IBU‐CYS 2 and ibuprofen: approximately 34.29, 27.03 and 31.50 respectively) while indicating no cytotoxicity. Therefore, these salts may be promising candidates for the development of effective formulations of this drug.
Effect of hybrid sizings on the surface morphology, mechanical behavior of basalt fibers, and fiber/epoxy composite properties
Authors: Agrawal Mayank , Durai Prabhakaran R. T. 
Published: October 2024

AbstractIn the present study, the basalt fibers (BFs) were treated with hybrid sizings consisting silane coupling agent (3‐Glycidoxypropyl)trimethoxysilane, and silicon dioxide nanoparticles (SNPs). Using acetone washing and heat treatment, the commercial sizing previously on the BFs was removed. Next, the fibers were dip‐coated, and silanes condensed on the surface of the fibers. Fiber samples were characterized using thermogravimetric analysis (TGA), atomic force microscopy (AFM), X‐ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). The test findings demonstrate that acetone extraction was an effective way to remove sizings. The AFM analysis and SEM micrographs demonstrate that SNP and silane particles were dispersed uniformly across the fiber surface. The single fiber tensile testing results indicated that the deposition of hybrid sizings enhanced the fibers strength. Because of the better adhesion between the fiber and epoxy, the hybrid sizings also improved the flexural strength by 22.28% and the interlaminar shear strength by 20.75%.Highlights
Hybrid sizings (silanes and nano‐particles) on the basalt fiber surface.
Characterization of the sizings and understanding of surface morphology.
Hybrid sizings resulted in better tensile strength.
Failure mechanisms of the fibers were observed using fractography.
The effect of hybrid sizing on ILSS and flexural properties was observed.
Association between gastroprotective agents and acute kidney injury in patients receiving non‐steroidal anti‐inflammatory drugs: Analysis of a Japanese hospital‐based database
Authors: Mitsuboshi Satoru , Imai Shungo , Kizaki Hayato , Hori Satoko 
Published: October 2024

AbstractIntroductionThe concomitant use of non‐steroidal anti‐inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs) potentially increases the risk of acute kidney injury (AKI). However, the risk of AKI has not been comprehensively assessed for the concomitant use of NSAIDs with gastroprotective agents such as misoprostol and PPIs. The objective of this study was to evaluate whether the use of various gastroprotective agents affects the risk of AKI in patients receiving NSAIDs.MethodsThe data analyzed were obtained from the JMDC hospital‐based administrative claims database between April 2014 and August 2022. Histamine‐2 receptor antagonists (H2RAs) were compared with PPIs or misoprostol in patients receiving NSAIDs. The primary outcome was the incidence of AKI. The covariates considered were age and sex, admission to intensive care unit, presence of comorbidities based on the modified Charlson Comorbidity Index, and use of renin‐angiotensin system inhibitors, loop diuretics, other diuretics, and lithium. AKI was identified by changes in serum creatinine. The distribution of AKI was analyzed using the log‐rank test, and estimates of the incidence of AKI were compared among the groups using a Cox proportional hazards model with time‐varying variables. Models were adjusted using a doubly robust method that accounts for the inverse probability of treatment weighting at baseline while adjusting for covariates.ResultsAfter screening, 11,688 patients were eligible for inclusion (1729 for H2RAs, 368 for misoprostol, and 9591 for PPIs). AKI occurred in 0.5% of H2RA recipients and 1.1% of PPI recipients; no AKI was observed in the misoprostol group. Compared with H2RAs, the risk of AKI tended to be higher with PPIs (adjusted hazard ratio 1.83, 95% confidence interval 0.92–3.63, p = 0.08).ConclusionCompared with H2RAs, PPIs may increase the risk of AKI in patients receiving NSAIDs, although no statistically significant difference was observed. Further research is required to assess the risk trade‐off with consideration of both peptic ulcer prevention and the increased risk of AKI in patients concurrently treated with NSAIDs and H2RAs, misoprostol, or PPIs.
Understanding Heat Dissipation Factors for Fixed‐Tilt and Single‐Axis Tracked Open‐Rack Photovoltaic Modules: Experimental Insights
Authors: Pretorius Johannes , Nielsen Shaun 
Published: October 2024

ABSTRACTThis paper presents the results of long‐term experiments conducted on fixed‐tilt (FT) and single‐axis tracked (SAT) open‐rack photovoltaic (PV) modules in South Africa. Utilising Faiman's heat dissipation model and data filtering method, the study demonstrates favourable comparisons of FT experimental results with literature while yielding novel heat dissipation factors for SAT modules. Enhanced heat dissipation is observed in no/low wind conditions for SAT modules compared to FT modules. Analyses reveal the influence of plane‐of‐array (POA) irradiance, wind speed and direction on module temperature, with SAT modules exhibiting greater heat dissipation stability. An investigation into data filtering methods suggests minor sensitivity for both configurations, with a slightly more pronounced impact on SAT modules. Assessments comparing module temperature predictions using diverse heat dissipation factors for FT modules reveal negligible sensitivity. This suggests that exact heat dissipation factor values may not be crucial for accurate predictions of module temperature in FT open‐rack systems. Annual power output simulations using PVsyst software demonstrate a 2.9% and 3.3% enhancement for FT and SAT configurations, respectively, when employing experimentally determined heat dissipation factors. These findings highlight the importance of realistic, configuration‐specific heat dissipation factors in optimising PV system performance, particularly in the competitive context of modern PV power plant construction and techno‐economic calculations.
RNAi of nuclear receptor E78 inhibits the cuticle formation in the molting process of spider mite, Tetranychus urticae
Authors: Li Zhuo , Li Qingyan , Peng Qixiang , Smagghe Guy , Li Gang 
Published: October 2024

AbstractBACKGROUNDThe two‐spotted spider mite, Tetranychus urticae, is an important pest mite in agriculture worldwide. E78, as a member of the nuclear receptor superfamily and a downstream responsive gene of ecdysteroids, plays a crucial role in regulating physiological behaviors such as development and reproduction in insects. However, its function in mites remains unclear. The aim of this study was to explore how E78 functions in the molting process of spider mites.RESULTSIn this study, reverse transcription quantitative polymerase chain reaction (RT‐qPCR) experiments to analyze the expression pattern of TuE78 during the development of Tetranychus urticae, demonstrated that the expression level of TuE78 was higher during the molting state than that after the completion of molting, and it reached a peak expression level when the deutonymph mites entered the molting stage. RNA interference (RNAi)‐mediated gene‐silencing of TuE78 resulted in 95% deutonymph mite molt failure. A series of analysis under a light microscope, and scanning and transmission electron microscopy revealed that RNAi mites died within the exuvium without ecdysis, and that apolysis had started but the new cuticle was thin and the typical cuticular lamellae were absent, indicating blockage of the post‐apolysial processes and explaining molt failure. Hence, transcriptome sequencing confirmed that the expression of cuticle protein and lipid metabolism‐related genes was significantly affected after TuE78 silencing.CONCLUSIONThis study demonstrated that TuE78 participates in the molting process of Tetranychus urticae by regulating the post‐apolysial processes with the formation of new cuticle and successful ecdysis. This in turn suggests the potential of TuE78 as a target for pest mite control and provides a theoretical basis for further exploration of the molecular regulatory mechanism of spider mite molting. © 2024 Society of Chemical Industry.
Progress in Biopolymer Coatings for Achieving Sustainable Paper and Paperboard Packaging for Food Applications: A Brief Review
Authors: dos Santos Lima Kennya Thayres , de Matos Fonseca Jéssica , Monteiro Alcilene Rodrigues , Valencia Germán Ayala 
Published: October 2024

ABSTRACTPaper and paperboard are cellulosic materials used to manufacture food packaging. However, their low resistance to water and fat, as well as their poor barrier properties have limited their packaging applications as food contact materials. The current review analyses the use of biopolymeric coatings as an alternative to improve surface and barrier properties in paper and paperboard with focus in food sector application. Advances in coated paper (board) can be classified into three groups: (1) coatings manufactured with a single biopolymer; (2) coatings manufactured with composite biopolymers; and (3) biopolymeric coatings incorporated with bioactive molecules or nanoparticles. The use of a single or composite biopolymer coating improved the mechanical, barrier properties, and grease resistance. In contrast, the use of chemical compounds and nanoparticles has imparted active properties (antibacterial and ethylene scavengers) in the resulting coating paper (board). The water vapour transmission rate has been reduced with the use of biopolymeric coatings. Future studies should focus on applying coated paper (board) in foods with a special interest in food self‐life, migration, and toxicity.
Combinatory Effect of Gemcitabine and 5‐Fluorouracil Investigated Through Chemoinformatics and Molecular Dynamics Simulation Against Breast Cancer
Authors: Sukumaran Sureba , Zochedh Azar , Chandran Kaliraj , Sultan Asath Bahadur , Kathiresan Thandavarayan 
Published: October 2024

ABSTRACTCo‐delivering FDA‐approved drugs can be less harmful and boost biological activity by targeting different protein mechanism at same time. Gemcitabine and 5‐Fluorouracil (GE5F) adduct work together to destroy cancer cells and increase the efficacy in the fight against breast cancer. The basis set B3LYP/6‐311 G was utilized in this investigation to improve the structure of GE5F adduct. The natural bond analysis exhibited the intermolecular interactions of the GE5F adduct. Electronic transitions were seen to be π → π*, and theoretical calculations were performed for the ultraviolet to visible spectrum. The energy gap between HOMO and LUMO was used to study the GE5F adduct's structural stability and reactivity; the computed energy gap (ΔE) was 3.912 eV. The Mulliken charge population was assessed and the complex structure's electrostatic potential was established. Weak interactions of the GE5F were assessed using RDG analysis, and topological aspects were investigated using LOL and ELF analysis. Investigating the GE5F adduct's adsorption, distribution, metabolism, excretion, and toxicity properties, the results confirmed that GE5F adduct comes under the safety parameters being a drug‐likeness molecule. Molecular docking experiments were conducted using target proteins for breast cancer. The complex molecule had a higher binding affinity as indicated by the docking scores, which validated the better combinatorial interaction between gemcitabine and 5‐Fluorouracil. With − 9.4 kcal/mol, the complex molecule's strongest binding capacity was against PARP protein, and stable confirmation was observed through molecular dynamic simulation for 100 ns with four hydrogen bond interactions. These in silico finding will pave a way for in vitro and in vivo experiments with better enhancement of FDA approved drugs.
Filter‐Based Average Dwell‐Time Tuning Approach for Adaptive Prescribed‐Time Tracking of Uncertain Switched Nonlinear Systems
Authors: Jang Seok Gyu , Yoo Sung Jin 
Published: October 2024

ABSTRACTThis paper addresses neural‐network‐based adaptive prescribed‐time (PT) tracking for uncertain switched systems with unmatched nonlinearities. A continuously switched adaptive tuning mechanism for neural network learning is developed by applying the average dwell time (ADT). First, a neural‐network‐based PT tracking control design strategy using the ADT‐based adaptive tuning mechanism is established for switched nonlinear systems in strict‐feedback form. A novel adaptive dynamic surface controller is designed recursively using a practical finite‐time scaling function and continuously switched tuning parameters. The switched adaptive tuning laws for neural networks are structured to reduce the conservatism associated with common adaptive laws. Then, a filter‐based tuning approach is employed to ensure the continuity of switched adaptive parameters with ADT in the designed controller. The practical PT stability of the closed‐loop system is demonstrated based on the boundedness of the adaptive parameters. Building upon this foundation, the proposed PT design approach is extended to control switched pure‐feedback nonlinear systems, even in cases where control directions are unspecified. The unknown sign problem encountered with switched virtual and actual control coefficient functions is resolved in the PT control framework. It is shown that the PT performance bound of the tracking error can be reduced by selecting the design parameter of the scaling function. Finally, simulation results illustrate the merits of the proposed theoretical approach.
Adaptive Saturated Obstacle Avoidance Trajectory Tracking Control for Euler–Lagrange Systems With Velocity Constraints
Authors: Fu Longbin , An Liwei 
Published: October 2024

ABSTRACTThis article pays attention to the obstacle avoidance trajectory tracking control problem for uncertain Euler–Lagrange (EL) systems subject to velocity constraints and input saturation. The existing obstacle avoidance results do not consider velocity constraints under input saturation, which means that an EL system may not be able to obtain sufficient control inputs to avoid a collision with an obstacle if it has a high speed when approaching the obstacle. Therefore, the velocity constraints in the obstacle avoidance tracking control are considered in this paper. A novel velocity constraint function that depends on the distance between the system and the obstacle is proposed. Integral‐multiplicative Lyapunov‐barrier functions (LBFs) are constructed and incorporated into the backstepping procedure to design an adaptive fuzzy obstacle avoidance tracking control scheme. Moreover, an auxiliary dynamic system is designed by constructing a bounded nonlinear vector related to an auxiliary variable to compensate for the effects of saturation. Through the Lyapunov method and boundedness analysis for the barrier function, it is shown that the protocol achieves obstacle avoidance for the EL system without violating the velocity constraints inside the obstacle detection region, while also guaranteeing the ultimate uniform boundedness of all the closed‐loop signals. Numerical simulations are presented to demonstrate the efficacy of the proposed control strategy.
The influence of changes in the economy structure on social sustainability in developing countries—A spatial approach
Authors: Jankiewicz Mateusz 
Published: October 2024

AbstractThis research presents an analysis of the influence of changes in the economy structure on social sustainability in developing countries. In this paper, this relationship is considered on a macroeconomic scale. The research utilises data from 98 selected developing countries located in Europe, Asia, Americas, and Africa from 2013 to 2020. The social conditions in developing countries, particularly located in Africa (due to health and hunger problems), are extensively discussed. The main goal of the study is to compare whether the economy servitisation in Africa affects same on the social sustainability as in the countries situated on other continents. This study describes social sustainability using selected determinants outlined in the first, second, and third goals of sustainable development (SD) formulated by the United Nations—SDG1 (no poverty), SDG2 (zero hunger), and SDG3 (good health and well‐being). The level of social sustainability is evaluated using a synthetic measure by Perkal. Moreover, spatio‐temporal sensitivity models are estimated and verified. The sensitivity parameter in these models demonstrates the impact of progress in the servitisation process on social sustainability. Furthermore, this connection is considered within separate groups of countries that are divided into four clusters depending on the continent on which they are located. The analysis presents that in the African countries the social conditions are the worst, but focus on the economy servitisation there can rapidly improve this situation. This results from the most sensitive social sustainability in the African countries caused by the economy servitisation.
Cost‐effectiveness and cost‐utility of optimized mercaptopurine treatment versus placebo in ulcerative colitis patients: The randomized controlled OPTIC trial
Authors: Löwenberg Mark , van Barreveld Marit , Volkers Adriaan , van Gennep Sara , Duijvestein Marjolijn , van Bodegraven Adriaan A. , Hulshoff Melanie S. , Jansen Jeroen M. , van Asseldonk Dirk , West Rachel , D’Haens Geert , de Boer Nanne , Dijkgraaf Marcel G. W. 
Published: October 2024

AbstractBackground and aimsWe assessed the cost‐effectiveness and cost‐utility of therapeutic drug monitoring (TDM)‐guided mercaptopurine treatment compared with placebo in ulcerative colitis (UC) patients failing 5‐aminosalicylates.MethodsData were gathered alongside the randomized controlled OPTIC trial (EudraCT: 2015‐005260‐41). The evaluation was performed from a health care and societal perspective as cost‐effectiveness and cost‐utility analyses with a time horizon of one year. Volumes and costs of in‐hospital care, out‐of‐hospital care, out‐of‐pocket expenses and productivity loss were assessed. The main outcomes were the extra costs per additional patient who achieved clinical remission and endoscopic improvement at 52 weeks (responders) and extra costs per quality‐adjusted life‐year (QALY) gained.ResultsIn total, 59 patients were randomized to the intervention (n = 29) and control (n = 30) group. Non‐significant differences in costs were €63 (−€1267 to €1434; P = 0.93) in favour of placebo from a health care perspective and −€742 (−€3683 to €2016; P = 0.64) in favour of mercaptopurine from a societal perspective. The higher proportion of responders and a non‐significant QALY difference of 0.0475 (−0.024–0.117) (P = 0.184) favouring patients on mercaptopurine treatment resulted in €165 extra costs per additional responder and €1326 extra costs per QALY gained from a health care perspective. From a societal perspective, dominance over placebo was observed with cost savings of €1937 per additional responder and €15,621 per QALY gained. The probability of optimised mercaptopurine treatment being cost‐effective was 0.80 at a willingness to pay per additional QALY of €20,000.ConclusionsTDM‐based mercaptopurine treatment in UC patients failing 5‐aminosalicylates is a cost‐effective strategy from a societal perspective.
Modelling the tumor microenvironment in vitro in prostate cancer: current and future perspectives
Authors: Yuan Kedi , Du Xinxing , Dong Liang , Pan Jiahua , Xue Wei 
Published: October 2024

AbstractProstate cancer is the most common cancer in over 50% of countries and the third most common malignancy worldwide. The tumor microenvironment includes the non‐cancerous cells and components present in the tumor, including the molecules they produce and release. Prostate cancer proliferation, angiogenesis, metastasis, and drug resistance are closely associated with the tumor microenvironment. With the continuous development of in vitro tumor models, they have gradually become important tools for recapitulating in vivo parental tumors and studying the reciprocal interactions between tumors and their microenvironment. In this perspective, we describe the significant in vitro models of prostate cancer, analyze the research results on incorporating the tumor microenvironment into these models, and compare their advantages and disadvantages. Furthermore, we highlight the future developmental direction of in vitro prostate cancer model research according to the hotspots of in vitro model research in other cancer types to facilitate precision medicine in prostate cancer.