bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reciprocal Feedback Between miR-181a and E2/ERα in Myometrium Enhances Inflammation Leading to Labor
Authors: Gao Lu , Wang Gang , Liu Wei-Na , Kinser Holly , Franco Hector L. , Mendelson Carole R. 
Published: July 2016

Context:
The initiation of term and preterm labor is associated with an up-regulated inflammatory response in myometrium; however, the underlying signaling pathways remain incompletely defined.

Objective:
To define the regulatory mechanisms that mediate the increased myometrial inflammatory response leading to labor, we investigated the roles of microRNAs (miRNA/miR).

Design and Setting:
Human myometrial tissues, isolated smooth muscle cells, and animal models were used to study miR-181a regulation of uterine inflammatory pathways and contractility.

Patients:
Myometrial tissues from 15 term pregnant women undergoing elective cesarean section (not in labor) and 10 term pregnant women undergoing emergency cesarean section (in labor) were used.

Results:
Expression of the highly conserved microRNA, miR-181a, was significantly decreased in mouse and human myometrium during late gestation. By contrast, the putative miR-181a targets, TNF-α, and estrogen receptor (ER)-α, and the validated target, c-Fos, key factors in the inflammatory response leading to parturition, were coordinately up-regulated. In studies using human myometrial cells, overexpression of miR-181a mimics repressed basal as well as IL-1β-induced TNF-α, C-C motif chemokine ligand 2 and 8 expression, whereas the expression of the antiinflammatory cytokine, IL-10, was increased. Overexpression of miR-181a dramatically inhibited both spontaneous and IL-1β-induced contraction of human myometrial cells. Notably, miR-181a directly targeted ERα and decreased its expression, whereas estradiol-17β reciprocally inhibited expression of mature miR-181a in myometrial cells.

Conclusions:
Thus, increased estradiol-17β/ERα signaling in myometrium near term inhibits miR-181a, resulting in a further increase in ERα and proinflammatory signaling. This escalating feedback loop provides novel targets and therapeutic strategies for the prevention of preterm labor and its consequences.
Apicoplast fatty acid synthesis is essential for pellicle formation at the end of cytokinesis in Toxoplasma gondii
Authors: Martins-Duarte Érica S. , Carias Maira , Vommaro Rossiane , Surolia Namita , de Souza Wanderley 
Published: July 2016

ABSTRACT
The apicomplexan protozoan Toxoplasma gondii, the causative agent of toxoplasmosis, harbors an apicoplast, a plastid-like organelle with essential metabolic functions. Although the FASII fatty acid biosynthesis pathway located in the apicoplast is essential for parasite survival, the cellular effects of FASII disruption in T. gondii had not been examined in detail. Here, we combined light and electron microscopy techniques – including focused ion beam scanning electron microscopy (FIB-SEM) – to characterize the effect of FASII disruption in T. gondii, by treatment with the FASII inhibitor triclosan or by inducible knockdown of the FASII component acyl carrier protein. Morphological analyses showed that FASII disruption prevented cytokinesis completion in T. gondii tachyzoites, leading to the formation of large masses of ‘tethered’ daughter cells. FIB-SEM showed that tethered daughters had a mature basal complex, but a defect in new membrane addition between daughters resulted in incomplete pellicle formation. Addition of exogenous fatty acids to medium suppressed the formation of tethered daughter cells and supports the notion that FASII is essential to generate lipid substrates required for the final step of parasite division.
Hospitality in hospitals: The importance of caring about the patient
Authors: Kelly Rosalind , Losekoot Erwin , Wright-StClair Valerie A. 
Published: July 2016

Abstract
Evidence suggests that hospital patients receive the medical treatment they need but are sometimes left feeling depersonalized and alienated with their overall treatment. This New Zealand study explored the lived experience of hospitality among adults during their recent hospital stay. A hermeneutic phenomenological methodology was used to design and conduct the study. Seven participants, aged 22 to 65 years, who had spent at least three days in a hospital for elective surgery were purposively recruited. Data were gathered using semi-structured, conversational-style individual interviews. Participant-validated, coherent stories were drawn from the transcripts and analysed. The findings revealed that hospitality showed itself in different ways to the participants. When present, they experienced feelings of comfort, of being at ease and of being healed. The implications for health care practitioners are that offering often small, yet heartfelt acts of hospitality may evoke powerful lived experiences that benefit the patient, suggesting that caring about the patient is an important element of the healing process.
Global citizenship, tourism and consumerism: A narrative enquiry into the global consumer-citizen spectrum in students’ study tour experiences
Authors: Hermann Inge , Meijer Kim , Van Koesveld Sofie 
Published: July 2016

Abstract
Higher Education Institutions (HEIs) increasingly embed international activities in their curricula as a way to stimulate global citizenship education (GCE). Nonetheless, there is much debate on the definition and impact of these activities for the development of students as reflective practitioners. Inspired by Roman’s discursive framework, this article examines three dominant conceptions of global citizenship experienced by students during study tours to Surinam. By means of a narrative analysis of 33 diaries collected during three study tours we have categorized students’ lived experiences along a global citizen-consumer spectrum. Our findings show that students’ accounts are mainly centred on notions of consumerism, including multiple colonialist and orientalist stances, while few are concerned with personal reflections related to global citizenship. Concluding, we argue that study tours are no guarantee of enhanced global citizenship; thus, much debate is still needed to determine the significance of study tours in fostering GCE.
A content analysis of corporate social responsibility: Perspectives from China’s top 30 hotel-management companies
Authors: Chen Xiaoqing , Peng Qingzhe 
Published: July 2016

Abstract
There is a growing demand for corporate social responsibility (CSR) in the tourism and hospitality industry, but its role in some emerging countries, such as China, has seldom been examined. The purpose of this article is to broaden research into CSR by considering it in the context of the Chinese hotel industry, so helping to fill this omission in the literature. Drawing its empirical material from CSR information released by a representative sample of Chinese hotel-management companies, this study reveals that – while there is considerable variation in the information that the 30 largest organizations provide publicly – they all place considerable importance on their highly valued stakeholders (community, environment, government, employee and customer), the other stakeholders (investor, supplier, mission and values) receive much less coverage. This uneven phenomenon is also reflected in the methods used to disseminate CSR information employed by these companies, which suggests that contextualized social, economic, and cultural differences should be taken into consideration in order to more effectively understand and practice CSR in emerging economies.
Everything goes back to the beginning: Television adaptation and remaking Nordic noir
Authors: Berger Richard 
Published: July 2016

Abstract
As television drama undergoes a renaissance across Europe and the United States, this article focuses on the remakes of ‘Nordic noir’ crime serials. The genre has its origins in contemporary literary fiction, and became a cinematic cause célèbre with the Swedish adaptations of Stieg Larsson’s Millennium novels, and the controversial US remake of The Girl with the Dragon Tattoo. While adaptation scholars have long discredited comparative approaches based on the source/target text binary organized along value-judgement lines, in terms of television remakes, the opposite is fast becoming the case; comparisons between different versions of the same narrative become a playful and almost vital aspect of contemporary adaptation. While some theorists have argued that remakes often attempt to efface previous versions, in television, the opposite can be true. In examining the remakes of The Girl with the Dragon Tattoo (Oplev, 2009), Forbrydelsen (2007–2012), Broen/Bron (2011–) and Broadchurch, (2013–) this article proposes that a new type of ‘synchronous’ or ‘active’ adaptation invites some audiences to engage in a far more playful exchange of textual moments, augmented and overseen by social media. In this way, adaptations can act as ‘logic-gates’ upon each other, and television remakes are now reflecting this.
Structures and Opportunities to Supply the Telecommunication Systems in Underground Mines
Authors: Wojaczek Antoni 
Published: July 2016

Abstract
Telecommunication systems in underground mines require reliable power supply both of stationary and underground devices. Special problems connected with power supply occur in a case when subscriber devices are located in explosion hazard areas. The paper presents the basic problems connected with power supply of stationary elements of safety systems as well as subscriber devices located in explosion hazard areas that are significantly distant from stationary elements. Acceptable methods of supplying the subscribers devices under technical environment conditions of mine undergrounds have been determined.
Modeling and Simulation of Coal Loading by Cutting Drum in Flat Seams
Authors: Gospodarczyk Piotr 
Published: July 2016

Abstract
This paper presents a methodology for modeling work of a coal shearer work in low longwall coal seams where the wall height does not exceed 1.5 m. In such conditions, an important issue is the process of loading the ore from shearer cutting drum on an armored face conveyor and selection of appropriate kinematic parameters to avoid choking. Discrete element method was used to model coal seam. This method allows for efficient simulation of physical systems composed of many separate components. Methods and algorithms based on existing theoretical models were developed to imitate coal cutting process. Main focus of analysis was put on coal stream movement for different variants of the shearer construction and kinematic parameters.
Infinitely many solutions for non-local problems with broken symmetry
Authors: Bartolo Rossella , De Nápoli Pablo L. , Salvatore Addolorata 
Published: July 2016

Abstract
The aim of this paper is to investigate the existence of solutions of the non-local elliptic problem

{

(

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Δ

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=

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+

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x
)

in
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Ω

,

u
=
0

on
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ℝ
n

∖
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,

\left\{\begin{aligned} &\displaystyle(-\Delta)^{s}u\ =\lvert u\rvert^{p-2}u+h(%
x)&&\displaystyle\text{in }\Omega,\\
&\displaystyle{u=0}&&\displaystyle\text{on }\mathbb{R}^{n}\setminus\Omega,\end%
{aligned}\right.

where

s
∈

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,

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>

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, Ω is an open bounded domain of

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n

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with Lipschitz boundary

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,

(

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s

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is the non-local Laplacian operator,

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<
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∗

{2<p<2_{s}^{\ast}}

and

h
∈

L
2

⁢

(
Ω
)

{h\in L^{2}(\Omega)}

. This problem requires the study of the eigenvalue problem related to the fractional Laplace operator, with or without potential.
Precision injection molding of freeform optics
Authors: Fang Fengzhou , Zhang Nan , Zhang Xiaodong 
Published: July 2016

Abstract
Precision injection molding is the most efficient mass production technology for manufacturing plastic optics. Applications of plastic optics in field of imaging, illumination, and concentration demonstrate a variety of complex surface forms, developing from conventional plano and spherical surfaces to aspheric and freeform surfaces. It requires high optical quality with high form accuracy and lower residual stresses, which challenges both optical tool inserts machining and precision injection molding process. The present paper reviews recent progress in mold tool machining and precision injection molding, with more emphasis on precision injection molding. The challenges and future development trend are also discussed.
Reforms in Rural Development and their Influence on Agricultural Extension of Uzbekistan: Experience and Challenges in Water Management
Authors: Pulatov Alim , Húska Dušan , Abdullaev Davran , Hirsch Darya 
Published: July 2016

Abstract
Nowadays science applies agricultural innovations in a wide range all over the world; however, number of water users in innovations is in smaller amounts. This might happen to a number of factors, for example lack of adequate knowledge exchange system, nominal extension services at places, lack of well-defined policies, barriers in ‘human’ minds change’, barriers at policy level. As for Uzbekistan, it could be said that practice of extension of innovations application and its diffusion in agricultural irrigation sector in Uzbekistan does not have much experience, however, before 1991 Uzbekistan was one of the Soviet Unions’ republics and as it is known, the Soviet Union had high practice in innovations in different sectors, as well as in agriculture. Although, since independence, Uzbekistan has continued to experience innovations in agricultural sector independently, their diffusion is at a challenging shape. This article captures the policy issue, how Uzbekistan started to develop water management issues in its economic reforms, it describes a case research on application of innovative technique on a farm level and accordingly, it tries to propose the aspects that need to be involved in future reforms to make the current situation be better managed.
Differentiating Rural Areas in Uzbekistan and Slovakia and their Classification
Authors: Ismailova Aygul 
Published: July 2016

Abstract
The characteristic of the concept “rural areas” is widely different, varying from country to country. Similarly, Uzbek rural areas quite differ from Slovak ones. However, in both countries there is not applied a concrete national typology for the classification of rural areas. Therefore, the main aim of the paper is to identify the differences between the rural areas in Uzbekistan and Slovakia and to classify them using the rural - urban typology based on OECD methodology. In the selected countries the rural areas are mainly identified by the number of population living in the rural local units. According to the results of the classification by using the OECD methodology, in Uzbekistan the significantly rural areas prevail whereas in Slovakia, the intermediate ones dominate. However, there is not a big difference in the share of rural population between predominantly rural areas and intermediate ones in the Slovak Republic. In contrast to Slovakia, the number of rural residents in the intermediate rural areas in Uzbekistan is about three times lower than rural population in predominantly rural areas. There is not a predominantly urban area according to this methodology in Uzbekistan, however in Slovakia, Bratislava is the only region considered as predominantly urban area where only 2.2% of rural population from the total population reside.
Evaluation of Selected Quality of Life Indicators in Lag “Dol Ná Nitra”
Authors: Baková Ingrida , Schwarcz Pavol 
Published: July 2016

Abstract
The paper focuses on quality of life of inhabitants in Slovak countryside as well as conditions for development of municipalities on possibilities of drawing European funds and the performance of Local Action Groups. Its main objective is to evaluate the effect of the Slovak Rural Development Programme 2007-2013 measures on increasing the quality of life in a selected region and to compare results in municipalities that were part of a public-private partnership and those they did not participate. The paper mainly deals with quality of life indicators defined in the field of employment and quality of employment.
Measuring Development of Selected Poverty Risk Indicators in V4 Countries with Specific Focus on Slovak Republic and its Regions
Authors: Beňuš Ondrej , Kováčik Marián , Žuffová Eva 
Published: July 2016

Abstract
This article is devoted to analysis of selected poverty indicators as measured by EU-Statistics on income and living conditions. Our orientation on these indicators underlines our focus on quantitative measurement. Spatial orientation was selected as the area of the Visegrad group countries serving as a research base for our investigation of poverty differences in the Central Europe. Further research is dedicated to Slovakia and its regions. In this article we aim to identify those quantitative poverty indicators that are responsible for poverty status of the most affected social group of people in the country.
A tumor suppressive role of lncRNA GAS5 in human colorectal cancer
Authors: Lei Yan , Jing-jing Li , Ke-nan Zhang , Qing-zhong Tian , Jin Li 
Published: July 2016

AbstractObjectiveIt is already known that long non-coding RNA growth arrest-specific 5 (GAS5) is downregulated in human colorectal cancer (CRC) cells inhibiting cell proliferation. We further analyzed its involvement in cell cycle distribution and apoptosis induction.MethodsWe measured the expression level of GAS5 in CRC tissues and cell lines with the corresponding non-tumoral cells. We also analyzed the roles of GAS5 in modulation of cell growth, cell cycle distribution and apoptosis by the CCK-8 method and flow cytometry. Western blots were performed to evaluate the protein level of cyclin D1 and p21 after overexpression of GAS5ResultsGAS5 expression was significantly reduced in CRC samples and cell lines. Overexpression of GAS5 induced cell growth arrest and induced cell apoptosis in vitro. Meanwhile, we found that the growth suppressive role of GAS5 might be attributed to the inhibition of G1-S phase transition, reflected by the downregulation of cyclin D1 and upregulation of p21.ConclusionOur results demonstrate that GAS5 is a crucial tumor suppressor in human CRC cells.
The tourist function in a car factory Audi Forum Ingolstadt example
Authors: Cudny Waldemar , Horňák Marcel 
Published: July 2016

Abstract
The article presents modern car industry and tourism issues. It is a case study of a multifunctional centre - the Audi Forum Ingolstadt, situated next to a large Audi factory in Ingolstadt, Germany. It was created in order to promote the Audi brand and provide service for the customers picking up their cars in Ingolstadt. It also performs tourist functions as it focuses on providing service for the people who arrive to visit the car factory, the Audi museum mobile and the region. The centre offers specific tourist products based on particular experiences, which may be included in industrial tourism. The facilities in the Audi Forum Ingolstadt are tourist assets in themselves; they may also be seen as tourist infrastructure. It is also a place where numerous events are held, attracting tourists. The Audi Forum Ingolstadt is an example of a multifunctional centre with distinctive tourist functions, situated on the premises of a large modern car factory.
Catering for large numbers of tourists: the McDonaldization of casual dining in Kruger National Park
Authors: Ferreira Sanette L.A. , W. Van Zyl Gesina 
Published: July 2016

Abstract
Since 2002 Kruger National Park (KNP) has subjected to a commercialisation strategy. Regarding income generation, SANParks (1) sees KNP as the goose that lays the golden eggs. As part of SANParks’ commercialisation strategy and in response to providing services that are efficient, predictable and calculable for a large number of tourists, SANParks has allowed well-known branded restaurants to be established in certain rest camps in KNP. This innovation has raised a range of different concerns and opinions among the public. This paper investigates the what and the where of casual dining experiences in KNP; describes how the catering services have evolved over the last 70 years; and evaluates current visitor perceptions of the introduction of franchised restaurants in the park. The main research instrument was a questionnaire survey. Survey findings confirmed that restaurant managers, park managers and visitors recognise franchised restaurants as positive contributors to the unique KNP experience. Park managers appraised the franchised restaurants as mechanisms for funding conservation.
The capital agglomeration of the Republic of Korea as a fuzzy central place system
Authors: Em Pavel P. 
Published: July 2016

Abstract
Explosive urbanization in the Republic of Korea from 1950 to 2010 marked by a growth in extensive urban agglomerations rendered unproductive the approach that was commonly used in the central place theory and which considered every element of the settlement system as a point in a homogeneous space. The paper suggests an alternative concept of fuzzy central place that makes possible the understanding of an internal heterogeneity in the distribution of central functions within the limits of urban agglomerations. This research was conducted using the example of the Capital agglomeration - the main element of the Republic of Korea’s urban settlement system. This “island” country, isolated by North Korea, has seen fantastic economic growth in the second half of the 20th century.
The influence of self-efficacy and socio-demographic factors on the entrepreneurial intentions of selected Youth Corp members in Lagos, Nigeria
Authors: Moa-Liberty Alausa Waheed , Tunde Arogundade Odunayo , Tinuola Odunuga Lateefat 
Published: July 2016

Abstract
This study examines the influence of self-efficacy and socio-demographic factors on the entrepreneurial intentions of selected Youth Corp members. The study adopted a cross-sectional survey design and a sample size of 300 National Youth Service Corp members were randomly selected in the five divisions of Lagos State with ages ranging from 18 to 30. Three hypotheses were tested using multiple regression and t-tests. The results show that there is a significant joint influence of sex, age, ethnicity and self-efficacy on entrepreneurial intentions (r2 = 0.90; P <.01]; male participants are more susceptible to entrepreneurial intentions than their female counterparts [t = 26.46, P <.01] and that Youth Corp members with a high self-efficacy rate significantly higher on entrepreneurial intentions (t = 25.09, P <.01]. Based on these findings, the study recommended that a self-efficacy programme should be included in the school curriculum so as to enhance entrepreneurial intentions among fresh graduates and, by so doing, reducing the high rate of unemployment in society. It was also recommended that future studies should use a larger sample and explore experimental methods so as to see if a causal relationship can be established among variables.