bluuebunny/crossref_metadata_2025_split huggingface dataset:
Headache patients’ satisfaction with telemedicine: a 12‐month follow‐up randomized non‐inferiority trial
Authors: Müller K. I. , Alstadhaug K. B. , Bekkelund S. I. 
Published: April 2017

Background and purposeWe investigated non‐acute headache patients’ long‐term satisfaction with a telemedicine consultation and consultation preferences in northern Norway. We hypothesized that patients were not less satisfied with telemedicine than traditional consultations. We also examined the influence of gender, age and education on satisfaction.MethodsFor 2.5 years, patients were consecutively screened, recruited and randomly assigned to telemedicine or traditional visits with a consultation at a neurological outpatient department. The primary endpoint was frequency of satisfied patients at 3 and 12 months. Secondary endpoints were satisfaction with consultation, communication, information, diagnosis, advice and prescriptions, and preferred visit form at 12 months.ResultsOf 402 participants, 279 (69.4%) answered questionnaires at both 3 and 12 month, and 291 (72.4%) responded at 12 months. The long‐term satisfaction of telemedicine patients was 124/145 (85.5%) compared with 118/134 (88.1%) in the traditional group (P = 0.653). The groups did not differ with respect to secondary endpoints, but females were more satisfied with telemedicine communication (P = 0.027). In the telemedicine group, 99/147 (67.3%) were indifferent to the type of consultation. Age and education did not alter the primary results.ConclusionsAt 1 year after a specialist evaluation for headache, telemedicine patients did not express less satisfaction than those with traditional consultation. Telemedicine specialist consultations may be a good alternative for headache patients in secondary care.
Effects of feeding two RRR‐α‐tocopherol formulations on serum, cerebrospinal fluid and muscle α‐tocopherol concentrations in horses with subclinical vitamin E deficiency
Authors: Brown J. C. , Valberg S. J. , Hogg M. , Finno C. J. 
Published: April 2017

SummaryBackgroundAlpha‐tocopherol (α‐TP) supplementation is recommended for the prevention of various equine neuromuscular disorders. Formulations available include RRR‐α‐TP acetate powder and a more expensive but rapidly water‐dispersible liquid RRR‐α‐TP (WD RRR‐α‐TP). No cost‐effective means of rapidly increasing serum and cerebrospinal fluid (CSF) α‐TP with WD RRR‐α‐TP and then sustaining concentrations with RRR‐α‐TP acetate has yet been reported.ObjectivesTo evaluate serum, CSF and muscle α‐TP concentrations in an 8‐week dosing regimen in which horses were transitioned from WD RRR‐α‐TP to RRR‐α‐TP acetate.Study designNon‐randomised controlled trial.MethodsHealthy horses with serum α‐TP of <2 μg/mL were divided into three groups and followed for 8 weeks. In the control group (n = 5), no α‐TP was administered. In the second group (Group A; n = 7), 5000 IU/day RRR‐α‐TP acetate was administered. In the third group (Group WD–A; n = 7), doses of 5000 IU/day of WD RRR‐α‐TP were administered over 3 weeks, followed by a 4‐week transition from WD RRR‐α‐TP to RRR‐α‐TP acetate, and a final 1 week of treatment with RRR‐α‐TP acetate. Serum samples were obtained weekly; muscle biopsies were obtained before, at 2.5 weeks and after supplementation. CSF samples were obtained before and after the 8‐week period of supplementation.ResultsSerum α‐TP increased significantly in Group WD–A at week 1 and remained significantly higher than in Group A and the control group throughout the transition, with inter‐individual variation in response. Serum α‐TP increased significantly by week 7 in Group A. CSF α‐TP increased significantly in Group WD–A only. Muscle α‐TP concentrations did not differ significantly across groups. Serum and CSF α‐TP were closely correlated (r = 0.675), whereas serum and muscle‐α‐TP concentrations were not correlated.Main limitationsThe study duration was short and data on pre‐transition CSF was lacking.ConclusionsThe administration of 5000 IU/day of water‐dispersible RRR‐α‐TP rapidly increases serum α‐TP. Serum and CSF α‐TP concentrations are sustained with a gradual transition to 5000 IU/day of RRR‐α‐TP acetate. Periodic evaluation of serum α‐TP concentrations is recommended because responses vary among individuals.
Dual layer SiC coating on matrix graphite sphere prepared by pack cementation and fluidized‐bed chemical vapor deposition
Authors: Zhou Ping , Zheng Zujie , Liu Rongzheng , Liu Xiaoxue , Liu Malin , Wang Taowei , Li Ziqiang , Shao Youlin , Zhao Hongsheng , Liu Bing 
Published: April 2017

AbstractA dual layer silicon carbide (SiC) coating including inner porous SiC (p‐SiC) layer and outer dense SiC (d‐SiC) layer was fabricated on the matrix graphite (MG) spheres of high‐temperature gas‐cooled reactor fuel elements by pack cementation and fluidized‐bed chemical vapor deposition process to improve the oxidation‐resistant property. Microstructure of the coating demonstrates different density and structure of the two SiC layers with no obvious boundaries between them. Weight gain curves of oxidation tests at 1773 K for 200 hours show that the coating could effectively protected the MG sphere by isolating the air infiltration with p‐SiC layer as the main functional layer and d‐SiC layer as the transition layer to improve the bond strength. Due to the transition function of p‐SiC layer, the coated spheres could understand more than 50 times thermal shocking tests from 1773 K to room temperature with no stress cracking.
Forgetting in Immortality
Authors: Felder Ryan Marshall 
Published: April 2017

AbstractIn the philosophical debate about the desirability of immortality it is argued that immortality could never be desirable, since it requires us to either take on a life where none of our projects or interests stimulate us anymore, or else to loosen our connections to our past selves and no longer survive. I argue that both concerns can be met by considering the role that partial forgetting of past experiences would play in the immortal life. One who loses some non‐essential memories of their past stands to be able to enjoy experiences that have grown tiresome with age. My contribution is to clarify how partial forgetting of only the non‐essential memories allays concerns about our potentially loosened connections to our earlier states. I then consider an objection to my account, that since the standards governing collective memory might be more demanding than those governing individual memory, immortal people might sacrifice aspects of their collective lives to render their own immortal lives enjoyable.
#GeriMedJC: The Twitter Complement to the Traditional‐Format Geriatric Medicine Journal Club
Authors: Gardhouse Amanda I. , Budd Laura , Yang Seu Y. C. , Wong Camilla L. 
Published: April 2017

Twitter is a public microblogging platform that overcomes physical limitations and allows unrestricted participation beyond academic silos, enabling interactive discussions. Twitter‐based journal clubs have demonstrated growth, sustainability, and worldwide communication, using a hashtag (#) to follow participation. This article describes the first year of #GeriMedJC, a monthly 1‐hour live, 23‐hour asynchronous Twitter‐based complement to the traditional‐format geriatric medicine journal club. The Twitter moderator tweets from the handle @GeriMedJC; encourages use of #GeriMedJC; and invites content experts, study authors, and followers to participate in critical appraisal of medical literature. Using the hashtag #GeriMedJC, tweets were categorized according to thematic content, relevance to the journal club, and authorship. Third‐party analytical tools Symplur and Twitter Analytics were used for growth and effect metrics (number of followers, participants, tweets, retweets, replies, impressions). Qualitative analysis of follower and participant profiles was used to establish country of origin and occupation. A semistructured interview of postgraduate trainees was conducted to ascertain qualitative aspects of the experience. In the first year, @GeriMedJC has grown to 541 followers on six continents. Most followers were physicians (43%), two‐thirds of which were geriatricians. Growth metrics increased over 12 months, with a mean of 121 tweets, 25 participants, and 105,831 impressions per journal club. Tweets were most often related to the article being appraised (87.5%) and ranged in thematic content from clinical practice (29%) to critical appraisal (24%) to medical education (20%). #GeriMedJC is a feasible example of using social media platforms such as Twitter to encourage international and interprofessional appraisal of medical literature.
Effect of Ficus carica leaf extract on the gene expression of selected factors in HaCaT cells
Authors: Turkoglu Murat , Pekmezci Erkin , Kilic Songul , Dundar Cihat , Sevinc Hakan 
Published: April 2017

SummaryBackgroundFicus carica Linn. (Fc), common fig, has been traditionally used for many metabolic, cardiovasculary, respiratory, gastrointestinal, and skin disorders. Several studies were performed showing its anti‐inflammatory, anti‐angiogenic, anticancerogenic, and tissue‐protective effects. In all of those studies, the positive effects of Fc were concluded as the result of its antioxidant and anti‐inflammatory features due to the polyphenols it contains.AimsTo study the phenolic compounds of Fc extract and to investigate the molecular basis of anti‐inflammatory, anti‐angiogenic, antimitotic, and anti‐androgenic effects of Fc leaf extract in vitro.Materials and MethodsThe gene expression levels of vascular endothelial growth factor (VEGF), tumor necrosis factor‐alpha (TNF‐a), interleukin 1‐alpha (IL‐1a), and 5 alpha‐reductase type II (SRD5A2) were tested in human keratinocyte cells (HaCaT) by RT‐qPCR.ResultsThe gene expression analysis showed that the plant extract caused statistically significant downregulation of VEGF, TNF‐a, IL‐1a, and SRD5A2 compared to the untreated cells.DiscussionThese preliminary results of this in vitro study may partially explain the clinical success of Fc in the traditional medicine.ConclusionTopical Fc leaf extract may be beneficial for some inflammatory disorders and androgen‐dependent disorders of the skin such as androgenetic alopecia.
Effects of Levothyroxine Administration and Withdrawal on the Hypothalamic‐Pituitary‐Thyroid Axis in Euthyroid Dogs
Authors: Ziglioli V. , Panciera D.L. , Troy G.C. , Monroe W.E. , Boes K.M. , Refsal K.R. 
Published: April 2017

BackgroundChronic supplementation can suppress the hypothalamic‐pituitary‐thyroid axis (HPTA) and make it difficult to assess thyroid function after withdrawal of levothyroxine.ObjectivesTo determine whether theHPTAis suppressed after levothyroxine administration in euthyroid dogs and the time required for resolution of any suppression.AnimalsTwenty‐eight healthy euthyroid dogs.MethodsA prospective, randomized study administering levothyroxine to euthyroid dogs for 8 weeks (group 1) or 16 weeks (group 2). Serum concentrations of total thyroxine (T4), free thyroxine (fT4) by equilibrium dialysis, thyroid stimulating hormone; thyrotropin (TSH), and 3,5,3′‐triiodothyronine (T3) were measured every 4 weeks during supplementation and for 16 weeks after levothyroxine was discontinued.ResultsMean serum concentrations of T4andfT4were significantly higher (P< .0001) andTSHwas lower (P< .0001) in all dogs during levothyroxine administration compared to baseline. Mean serum concentrations of T4,fT4,andTSHin both groups, beginning 1 week after levothyroxine was discontinued, were significantly different (P< .01) compared to values during levothyroxine administration but not compared to baseline values (P> .3).Conclusions and Clinical ImportanceAssessing thyroid function tests 1 week after cessation of levothyroxine at 26 μg/kg once a day for up to 16 weeks will provide an accurate assessment of thyroid function in healthy euthyroid dogs.
Efficacy of Holmium Laser Transurethral Incision of the Prostate in Symptomatic Mild‐to‐Moderate Benign Prostate Enlargement Based on Preoperative Characteristics
Authors: SUH Yoon Seok , KO Kwang Jin , KIM Tae Heon , SUNG Hyun Hwan , LEE Kyu‐Sung 
Published: April 2017

ObjectiveTo investigate the efficacy of Holmium laser transurethral incision of the prostate (Ho‐TUIP) with preoperative characteristics based on urodynamic parameters.MethodsThe medical records of 40 consecutive cases of Ho‐TUIP in patients unresponsive to medical treatment were retrospectively reviewed. The efficacy of Ho‐TUIP was analyzed according to preoperative factors, including urodynamic parameters. Treatment success was confirmed if overall efficacy demonstrated an improvement that was “good or greater” according to the criteria developed by Homma et al. Predictive factors of treatment success were analyzed using logistic regression analysis with demographics, symptom questionnaires, prostate size, and urodynamic parameters. Postoperative complications and Global Response Assessment (GRA) were investigated.ResultsMean age was 60.9 years (range 37–84), mean follow‐up period was 36.6 months (range 6.3–114.8), and mean prostate size was 23.5 mL (range 12.7–39.5). All patients underwent medical treatment before Ho‐TUIP, and mean medication duration was 50.5 months (range 3.4–140.0). The treatment success rate was 60.0%. Treatment success rates were higher in the bladder outlet obstruction index (BOOI) ≥20 group (n = 26) than in the BOOI <20 group (n = 14) (p = 0.003). In logistic regression analysis, BOOI ≥20 was a predictor of treatment success (OR 7.60, 95% CI 1.60–35.90, P = 0.010). Among patients who maintained an active sex life, 77.8% (14/18) reported retrograde ejaculation. In terms of GRA, 81.5% (31/38, two patients expired) of patients improved at the final follow‐up.ConclusionsHo‐TUIP is an effective procedure with tolerable complications for the treatment of symptomatic mild‐to‐moderate BPE in patients with BOOI ≥20 that are unresponsive to medical treatment.
Fifty Million Elvis Fans Can't be Wrong
Authors: Belot Gordon 
Published: April 2017

AbstractThis essay revisits some classic problems in the philosophy of space and time concerning the counting of possibilities. I argue that we should think that two Newtonian worlds can differ only as to when or where things happen and that general relativistic worlds can differ in something like the same way—the first of these theses being quaintly heterodox, the second baldly heretical, according to the mores of contemporary philosophy of physics.
The plastid outer membrane localized LPTD1 is important for glycerolipid remodelling under phosphate starvation
Authors: Hsueh Yi‐Ching , Ehmann Christian , Flinner Nadine , Ladig Roman , Schleiff Enrico 
Published: April 2017

AbstractGlycerolipid synthesis in plants is coordinated between plastids and the endoplasmic reticulum (ER). A central step within the glycerolipid synthesis is the transport of phosphatidic acid from ER to chloroplasts. The chloroplast outer envelope protein TGD4 belongs to the LptD family conserved in bacteria and plants and selectively binds and may transport phosphatidic acid. We describe a second LptD‐family protein in A. thaliana (atLPTD1; At2g44640) characterized by a barrel domain with an amino‐acid signature typical for cyanobacterial LptDs. It forms a cation selective channel in vitro with a diameter of about 9 Å. atLPTD1 levels are induced under phosphate starvation. Plants expressing an RNAi construct against atLPTD1 show a growth phenotype under normal conditions. Expressing the RNAi against atLPTD1 in the tgd4–1 background renders the plants more sensitive to light stress or phosphate limitation than the individual mutants. Moreover, lipid analysis revealed that digalactosyldiacylglycerol and sulfoquinovosyldiacylglycerol levels remain constant in the RNAi mutants under phosphate starvation, while these two lipids are enhanced in wild‐type. Based on our results, we propose a function of atLPTD1 in the transport of lipids from ER to chloroplast under phosphate starvation, which is combinatory with the function of TGD4.
Helping others or helping oneself? An episodic examination of the behavioral consequences of helping at work
Authors: Gabriel Allison S. , Koopman Joel , Rosen Christopher C. , Johnson Russell E. 
Published: April 2017

AbstractScholars have paid an increasing amount of attention to organizational citizenship behaviors (OCBs), with a particular emphasis on helping others at work. In addition, recent empirical work has focused on how OCB is an intraindividual phenomenon, such that employees vary daily in the extent to which they help others. However, one limitation of this research has been an overemphasis on well‐being consequences associated with daily helping (e.g., changes in affect and mental depletion) and far less attention on behavioral outcomes. In this study, we develop a self‐regulatory framework that articulates how helping others at work is a depleting experience that can lead to a reduction in subsequent acts of helping others, and an increase in behaviors aimed at helping oneself (i.e., engaging in political acts). We further theorize how two individual differences—prevention focus and political skill—serve as cross‐level moderators of these relations. In an experience sampling study of 91 full‐time employees across 10 consecutive workdays, our results illustrate that helping is a depleting act that makes individuals more likely to engage in self‐serving acts and less likely to help others. Moreover, the relation of helping acts with depletion is strengthened for employees who have higher levels of prevention focus.
Addition of Hydrogen Peroxide to Groundwater with Natural Iron Induces Water Disinfection by Photo‐Fenton at Circumneutral pH and other Photochemical Events
Authors: Gutiérrez‐Zapata Héctor Mario , Alvear‐Daza John Jairo , Rengifo‐Herrera Julián Andrés , Sanabria Janeth 
Published: April 2017

AbstractSamples of natural groundwater (with low turbidity, neutral pH and 0.3 mg L−1 iron concentration) inoculated with Escherichia coli K‐12 were exposed to simulated solar light both in the presence and in the absence 10 mg L−1 of H2O2. Results demonstrated that the viability of E. coli (by DVC–FISH) was grounded to zero after 360 min of irradiation. This abatement could be caused by the oxidative stress induced by radicals or another photo‐induced reactive oxygen species. Two 23 factorial experimental designs enabled the evaluation of the effects of chemical factors on the inactivation of E. coli. The first experimental design considered the pH, iron and H2O2, while the second evaluated the ions fluoride, carbonate and phosphate found in groundwater. pH was found to play a key role in the inactivation of E. coli. The best reduction in viability was obtained at the lower pH (6.75), while a nonsignificant effect was observed when iron or H2O2 concentrations were raised. At higher concentrations, anions, such as carbonate and phosphate, negatively affected the E. coli abatement. However, a higher concentration of fluoride accelerated it. In all experiments, the pH was observed to rise to values higher than 8.0 units after 360 min of treatment.
Ovarian follicle development and genital tract characteristics in different birthweight gilts at 150 days of age
Authors: Almeida FRCL , Alvarenga Dias ALN , Moreira LP , Fiúza ATL , Chiarini‐Garcia H 
Published: April 2017

ContentsIn the last decades, selection for improved prolificacy has resulted in higher litter sizes and has thereby increased the proportion of low birthweight (LW) piglets. It is well documented that LW piglets have lower growth performance, muscle accretion and poor carcass quality. However, little is known about the relations of birthweight with subsequent reproductive performance in gilts. This study investigated the effects of birthweight on reproductive tract and ovarian follicle development in 150‐day‐old gilts. Twenty eight female pigs of different birthweight ranges (high‐HW: 1.8–2.2 kg; low‐LW: 0.8–1.2 kg) from higher parity commercial sows were reared until 150 days of age, and their body weights were recorded at weaning, end of nursery and end of the grower‐finisher phase. The animals were killed and their reproductive tracts collected for biometrical and histomorphometrical analysis. LW gilts showed significantly lower body weights and growth rates during all phases of production compared to their HW counterparts (p < .01). Most biometrical measurements of the reproductive tract were similar between the experimental groups, except vaginal length and the gonadossomatic index (relative ovarian weight), which were affected by birthweight class (p < .05). LW females also showed fewer medium size (3–5 mm; p < .01) ovarian follicles, pre‐antral follicles (p < .07) and more atretic follicles per ovarian cortex area (p < .05). Therefore, besides the effects on post‐natal growth performance, birthweight affects vaginal length and the follicular dynamics process, which may impair the reproductive performance of replacement gilts.
Suberoylanilide hydroxamic acid, a novel histone deacetylase inhibitor, improves the development and acetylation level of miniature porcine handmade cloning embryos
Authors: Sun JM , Cui KQ , Li ZP , Lu XR , Xu ZF , Liu QY , Huang B , Shi DS 
Published: April 2017

ContentsHistone deacetylase inhibitors (HDACis) can change the histone acetylation and significantly enhance the developmental competence of the pre‐implantation SCNT embryo. To select a proper histone deacetylase inhibitor to improve the success rate and potentially developmental ability of handmade cloning (HMC) embryos of miniature porcine, we compared the effect of two histone deacetylase inhibitors (SAHA vs. VPA) on HMC embryo development, their histone acetylation level and the expression level of relevant genes. The blastocyst rate and number of blastocyst cells of HMC embryos treated with SAHA (SAHA‐HMC) or VPA (VPA‐HMC) were significantly higher than those of control (Control‐HMC), respectively, but there were no significant difference between SAHA‐HMC and VPA‐HMC groups. In addition, the acetylation level (AcH4K8) of Control‐HMC and VPA‐HMC embryos at the blastocyst stage, respectively, was significantly lower than that of in vitro fertilized (IVF) and SAHA‐HMC embryos. However, the acetylation H4K8 of the blastocysts had no significant difference between SAHA‐HMC and the IVF groups. The SAHA‐HMC blastocysts indicated comparative expression levels of Oct4 and HDAC1 (histone deacetyltransferase gene) with those of IVF blastocysts. In contrast, the expression levels of Oct4 were lower and those of HDAC1 were higher in the VPA‐HMC and Control‐HMC blastocysts, respectively, compared to those of the IVF blastocysts. Our results demonstrated that the HMC embryos treated by SAHA could promote the pre‐implantation development and increase the levels of histone H4K8 acetylation and the expression of the OCT4 gene, yet decrease the expression of the HDAC1 gene to the comparable level of the IVF embryos. Our results proved that SAHA may be a better histone deacetylase inhibitor for porcine HMC compared to VPA, and furthermore, it may indicate that SAHA can effectively correct the abnormal histone acetylation during the HMC embryo development and subsequently improve the full‐term developmental potential of the HMC embryos after embryo transplantation.