bluuebunny/crossref_metadata_2025_split huggingface dataset:
Based on near-infrared spectroscopy and chemometrics to rapidly evaluate the adulteration of Ganoderma lingzhi powder
Authors: Zhang Yanhong , Zhong Lingjiao , Su Hui , Wang Chenye , Wang Pan , Shao Qingsong , Zhang Ailian 
Published: October 2024

Abstract

Ganoderma lingzhi, the dry fruiting bodies of G. lucidum or G. sinensis, is a microbial food of high nutritional and health value. It is expensive but in high demand. In pursuit of higher profits, counterfeit products adulterated with G. lingzhi, such as G. applanatum, have appeared in the market. To identify the authenticity and forecast the degree of adulteration in Ganoderma lingzhi powder rapidly and non-destructively, the combination of near-infrared spectroscopy (NIRS) and chemometrics was used. Partial least squares discriminant analysis (PLS-DA), back propagation neural network (BPNN), support vector machine (SVM), and random forest (RF) were adopted as qualitative identification of G. lingzhi authenticity model methods, and partial least-squares (PLS) was developed as a quantitative prediction of adulteration content. Preprocessing and feature variables selection methods were developed to optimize the model and screen the best model. Among these experimental approaches, PLS-DA + first-order derivatives (D1), SVM + D1 + Competitive adaptive reweighted sampling (CARS), RF + standard normal variate transform (SNV) and BPNN + D1 + Uninformative variable elimination (UVE) + CARS achieved 100% classification accuracy. SVM + second-order derivatives (D2) + CARS and BPNN + D2 + CARS identified all adulterated G. lucidum, PLS-DA + D1 + UVE + CARS, RF + D2 + Genetic algorithm (GA), SVM + D2 + GA, and BPNN + D2 + CARS could distinguish all adulterated G. sinensis effectively.
Stator Currents and Rotor Equivalent Sources Modelling and Analysis of Dfig in Wind Energy Systems
Authors: srav barri 
Published: October 2024

Abstract

The Doubly-Fed Acceptance Generator (DFIG) plays a critical part in present day wind vitality frameworks due to its adaptability in variable-speed applications, tall proficiency, and capability to work beneath fluctuating wind conditions. In the show situation, DFIGs are broadly utilized in wind turbines since they permit autonomous control of dynamic and receptive control, upgrading framework steadiness and vitality productivity. The variable-speed operation empowered by the rotor-side converter too makes a difference moderate mechanical stresses on the turbine, progressing generally framework reliability. The Proportional-Integral (PI) control methodology for DFIGs, advertising a few focal points such as effortlessness, ease of usage, and vigorous execution beneath different working conditions. By controlling both stator and rotor-side voltages and streams, PI controllers proficiently oversee dynamic and receptive control stream, guaranteeing smooth network integration. The PI control approach gives steady energetic reaction, diminished motions, and improved framework execution, making it a well-known choice for both grid-connected and standalone DFIG applications. This investigates rotor and stator current flow for torque and control control, giving experiences into how successful control can optimize control yield and make strides framework steadiness. By considering these cases, the proposed control strategy illustrates made strides execution in controlling electrical amounts, accomplishing craved control stream, and minimizing unsettling influences in real-world operational scenarios.
Clinical outcomes with all-oral regimens in patients of drug-resistant tuberculosis: A prospective study in a tertiary hospital in North India
Authors: Kumar Vijay , Sri.Bhar G.S. , Bhatia Mohit , Chakrabarti Sankha Shubhra , Kaur Upinder , Mishra JK 
Published: October 2024

Abstract

Objective:
The main aim of this study is to provide therapeutic outcomes with bedaquiline-based all-oral regimens of drug-resistant tuberculosis (DR-TB).
Methods: A prospective observational study was conducted from August 2022 to March 2024 and patients of DR-TB on all-oral regimens were enrolled.
Results:
Seventy-three patients from long-oral (LO) regimens and 15 from the short-oral (SO) regimen were followed up at 6 months. Sixty-two (84.9 %) patients of LO, and 11 (67.9 %) patients of SO regimen achieved microbiologic improvement in one sample. Clinical improvement occurred in the majority. Forty-five (60.8 %) patients of LO and six (35.3%) patients of SO regimen required treatment modification, and the major reason was intolerability due to peripheral neuropathy. Skin pigmentation (43.8%), anemia (35.6%), and thrombocytopenia (26%) were other common adverse events (AEs), and optic neuritis occurred in two patients in the LO regimen. Hepatitis and thrombocytopenia occurred commonly with regimens combining bedaquiline and delamanid. Linezolid dose was reduced in 45.2% and the drug was replaced in 17.8%, commonly by pyrazinamide and delamanid.
Conclusion:
Interim microbiological outcomes with all-oral regimens of DR-TB were favorable. Extended monitoring is needed to assess the sustenance of treatment effect. AEs such as peripheral neuropathy are a major challenge and emphasize the need for newer regimens with better safety profiles.
Ferroptosis exacerbates myocardial ischemia-reperfusion injury via worsening oxidative stress and inflammatory responses: the role of Ferritin/SLC7A11/GPX-4 signaling pathway
Authors: Wang Lihong , Li Dongfang , Jia Zhi 
Published: October 2024

Abstract

Ferroptosis is closely linked to pathological processes in cardiomyocytes. However, the role of ferroptosis in myocardial ischemia-reperfusion injury (MI/RI) and its underlying mechanisms are unknown. Transitional accumulation of iron ions, as well as oxidative stress and lipid peroxidation production were found in the MI/RI model. These were significantly inhibited by an iron death inhibitor. In MI/RI-induced tissue damage and inflammatory responses, inhibition of ferroptosis reduced cardiac infarct area and resisted inflammation. Mechanistic investigations show that inhibition of ferroptosis via the Ferritin/SLC7A11/GPX-4 axis can target MI/RI mitigation, highlighting the potential of inhibiting ferroptosis as a novel strategy for therapeutic of MI/RI.
Adaptive Behavior-Based Ransomware Detection via Dynamic Flow Signatures
Authors: Loco Pedro , Alonso Sebastian , Hartmann George , Whitmore James , McLaughlin Edward 
Published: October 2024

Abstract

Ransomware continues to pose a significant threat to both individuals and organizations, evolving with sophisticated tactics that bypass traditional detection methods. The introduction of Adaptive Behavior-Based Ransomware Detection (ABRD) presents a dynamic solution capable of identifying ransomware through real-time behavioral analysis, bypassing the limitations of signature-based techniques. ABRD operates through the extraction of flow signatures, capturing operational characteristics of ransomware attacks, which allows for the detection of novel and zero-day variants without relying on predefined signatures. The system utilizes machine learning models to analyze these behavioral patterns, continuously adapting to emerging threats and ensuring high detection accuracy. Experimental evaluations demonstrated ABRD's effectiveness in handling encrypted communications, minimizing false positives, and scaling efficiently across network environments. Its ability to detect ransomware in real-time, combined with adaptive learning capabilities, positions ABRD as a powerful tool for automating cybersecurity defenses and addressing the challenges posed by the constantly evolving landscape of ransomware attacks.
Приманка строгости: математическая традиция в эпоху научной революции раннего Нового времени
Authors: И.С. Дмитриев 
Published: October 2024

Раздел книги посвящен рассмотрению ряда важных аспектов становления математической традиции в натурфилософии периода научной революции раннего Нового времени. Показано, что в этот период сформировалось критическое отношение к свойственной аристотелизму маргинализации математики по причине ее иррелевантности к поискам причинных объяснений природных явлений, что способствовало постепенному освобождению так называемых смешанных математических наук (mathematicae mixtae или mediae [СМН]) от ограничений аристотелевой эпистемологии. В ситуации научной революции, точнее, ее натурфилософского этапа (XVI–XVII вв.), имела место не математизация картины мира (или натуральной философии), — математика продолжала применяться там, где она использовалась и ранее, т.е. в СМН (хотя со временем математический аппарат обогащался новыми методами), — а скорее физикализация СМН, благодаря чему они стали частью натурфилософского знания. Вместе с тем, в ряде случаев использование математики при изучении тех или иных явлений имело селективный характер. В качестве характерного примера рассмотрена крайне негативная реакция математиков Общества Иисуса (иезуитов) на становление и распространение концепции бесконечно малых величин и «метода неделимых» Б. Кавальери, которые стали основой дифференциального и интегрального исчислений.
This book section is devoted to the consideration of a number of important aspects of the formation of the mathematical tradition in natural philosophy during the Scientific Revolution of the early modern period. It is shown that during this period a critical attitude to the marginalization of mathematics inherent in Aristotelianism due to its irrelevance to the search for causal explanations of natural phenomena was formed, which contributed to the gradual liberation of the so-called mixed mathematical sciences (mathematicae mixtae or mediae [MMS]) from the limitations of Aristotelian epistemology. In the situation of the scientific revolution, more precisely, its natural philosophical stage (16th– 17th cc.), there was not a mathematization of the world picture (or natural philosophy) — mathematics continued to be used where it had been used before, i.e. in the MMS (although over time the mathematical apparatus was enriched with new methods) — but rather a physicalization of the MMS, thanks to which they became part of natural philosophical knowledge. At the same time, in a number of cases, the use of mathematics in the study of certain phenomena was selective. As a typical example, the section considers the extremely negative reaction of the mathematicians of the Society of Jesus (Jesuits) to the formation and spread of the concept of infinitesimals and the “method of indivisibles” of B. Cavalieri, which became the basis of differential and integral calculus.
Construction Risk Assessment of Super-Large-Diameter Shield Tunnel in Karst Area Based on FAHP-TOPSIS Method
Authors: Liu Jiguo , Song Ming , Zhou Yongtao 
Published: October 2024

Background:
In recent years, construction accidents happen frequently in shield tunnel crossing
karst caves due to the complex karst geological structure. These are more obvious in super-large-diameter
shield tunnel during construction. In the past, the studies and patents of risk assessment tended
to be subjective since these reviews were mainly based on experience.

Methods:
A super-largediameter tunnel model is constructed by using calculation principle of FAHP--
TOPSIS method based on quantitative analysis and objective weighting method to conduct risk assessment
in karst area based on risks evaluated in a shield tunnel project under construction in a city. The
risk classification is formulated, and the risk assessment system for a super-large-diameter shield tunnel
under construction in karst area is developed to perform computation for assessment.

Results:
The results show that the closeness of the construction risk for a shield tunnel with super-
large-diameter crossing the karst area is 0.034, and the risk level is V, that is, high risk, which
brings great potential safety hazard to tunnel construction. The computation results are consistent with
those of site conditions to verify the feasibility and effectiveness of the method.

Conclusion:
The results have provided a reference for the risk assessment of similar engineering practice
under construction.
Article Highlights:
● At present, many researchers focus on risk assessment management of shield method, but there is a
lack of research on risk assessment of shield construction in the context of cavern development, in contrast,
this study carries out risk assessment of karst super-large-diameter shield construction, which is a
high research innovation.
● With the help of reliable and novel research tools, this study constructs a risk assessment model
based on the calculation principle of FAHP-TOPSIS method with quantitative and objective empowerment
for the construction of oversized diameter shield tunnels in karst areas, which is able to calculate
the risk level more accurately.
● The system constructed in this study can be applied to the field construction. The calculation results
of the construction risk assessment system of super-large-diameter shield tunnel in karst area constructed
in this paper were compared with the field situation, and the match was good, which can provide a
reference for other similar projects and guarantee the safety of field construction, so it has a good promotion.
Malignancy Detection in Lung and Colon Histopathology Images by Transfer Learning with Class Selective Image Processing
Authors: Sukhavasi Vidyullatha , Kulkarni Shridhar , V Raghavendran , C Dastagiraiah , Apat Shraban Kumar , Reddy Pundru Chandra Shaker 
Published: October 2024

Aims & Background:
Due to its ferocity, enormous metastatic potential, and variability,
cancer is responsible for a disproportionately high number of deaths. Cancers of the lung
and colon are two of the most common forms of the disease in both sexes worldwide. The excellence
of treatment and the endurance rate for cancer patients can be greatly improved with
early and precise diagnosis.

Objectives & Methodology:
We suggest a computationally efficient and highly accurate strategy
for the rapid and precise diagnosis of lung and colon cancers as a substitute for the standard
approaches now in use. The training and validation procedures in this work made use of an
enormous dataset consisting of lung and colon histopathology pictures. There are 25,000 Histopathological
Images (HIs) in the dataset, split evenly among 5 categories (mostly lung and
colon tissues). Before training it on the dataset, a pretrained neural network (AlexNet) had its
four layers fine-tuned.

Results:
The study enhances malignancy detection in lung and colon histopathology images by
applying transfer learning with class-selective image processing. Instead of enhancing the entire
dataset, a targeted contrast enrichment was applied to images from the underperforming
class, improving the model's accuracy from 92.3% to 99.2% while reducing computational
overhead. CONCLUSION: This approach stands out by emphasizing class-specific enhancements,
leading to significant performance gains. The results meet or exceed established CAD
metrics for breast cancer histological images, demonstrating the method's efficiency and effectiveness.
Boon Plant Calendula Officinalis Linn. (CO): An Investigation, Ethnopharmacological, Phytoconstituent Review’
Authors: Gupta Naincy , Choubey Ankur , Gupta Naveen , Rajput Dharmendra , Shukla Mukesh Kumar 
Published: October 2024

Introduction:
Calendula (English Marigold), or "Pot Marigold," is a well-known herbal plant from the family of Asteraceae, which has been used for thousands of years as a me-dicinal herb. It is one of the most widely used aromatic herbs in the Ayurvedic system of medi-cine, which is based on the ethnological significance of the plant. Extracts of this plant have been found to possess a range of therapeutic benefits, including anti-hyperlipidaemia, cardiovascular and antidiabetic properties, as well as antioxidant and anti-inflammatory properties. Additionally, it has been found to be effective in wound healing and has anti-cancer, anti-hepatitis, antibacteri-al, and antiretroviral properties. Traditionally, it has been used as a herbal remedy to treat skin tumours and dermatological lesions as well as ulcers and swellings, as well as nervous disorders.

Aims:
In addition to ethnopharmacology, pharmacology, and toxicology, this abstract also covers the morphology, microscopy, phytoconstituents, pharmacological reports, phytochemistry, and toxicity of the well-known Calendula species. Cosmetic ingredients derived from the C offici-nalis plant include extracts, flower oil, seed oil, and other components of the plant. These com-ponents include minerals, carbohydrates, and lipids; phenolic acids; flavonoids; tannins; couma-rins; sterols; steroids; monoterpenes; sesquiterpene; triterpenes; tocopherol; quinones; amino ac-ids; and resins. A chemical analysis of these ingredients reveals a wide variety of chemical com-pounds, including amino acid, triterpenoid, quinone, flavonoid, volatile oil, carotenoid, and other chemicals. Some Calendula officinalis species have medicinal value, and a literature review high-lights their utilization.

Results:
Calendula officinalis has a wide range of medicinal properties, ranging from antibacte-rial and antifungal properties to anthelmintic and antiviral properties. Additionally, it has antioxi-dant and hepatoprotective properties, as well as cardioprotective and wound-healing properties. Furthermore, it has been used to treat gastrointestinal, eye, and skin diseases. The plant has the potential to be a significant medicinal resource for mankind. It exhibits anti-HIV, cytotoxic, anti-inflammatory, hepatoprotective, and spasmolytic properties. The plant is used in almost 200 cosmetic formulations and has the potential for further research.

Conclusion:
This review emphasizes the future scope of Calendula species, focusing on their multifarious biological activities and potential applications as medicinal agents. This research fills gaps in existing studies, allowing researchers to validate traditional claims and advance the safe and effective use of CO in treating various ailments.
Occurrence of Stigmatizing Documentation Among Hospital Medicine Encounters With Opioid-Related Diagnosis Codes: Cohort Study
Authors: Bradford William S , Bratches Reed W R , Porras Hollie , Chen David R , Gagnon Kelly W , Ascher Simon B 
Published: October 2024

Background
Physician use of stigmatizing language in the clinical documentation of hospitalized adults with opioid use is common. However, patient factors associated with stigmatizing language in this setting remain poorly characterized.

Objective
This study aimed to determine whether specific demographic factors and clinical outcomes are associated with the presence of stigmatizing language by physicians in the clinical documentation of encounters with opioid-related ICD-10 (International Statistical Classification of Diseases, Tenth Revision) codes.

Methods
Hospital encounters with one or more associated opioid-related ICD-10 admission diagnoses on the hospital medicine service during the 2020 calendar year were analyzed for the presence of stigmatizing language in history and physical and discharge summaries. Multivariable adjusted logistic regression models were used to determine associations of age, race, gender, medication for addiction treatment use, against medical advice discharge, homelessness, comorbid polysubstance use, comorbid psychiatric disorder, comorbid chronic pain, cost, and 30-day readmission with the presence of stigmatizing language.

Results
A total of 221 encounters were identified, of which 64 (29%) encounters had stigmatizing language present in physician documentation. Most stigmatizing language was due to use of “substance abuse” rather than the preferred term “substance use” (63/66 instances). Polysubstance use and homelessness were independently associated with the presence of stigmatizing language (adjusted odds ratio [aOR] 7.83; 95% CI 3.42-19.24 and aOR 2.44; 95% CI 1.03-5.90) when controlling for chronic pain and other covariates.

Conclusions
Among hospital medicine encounters with an opioid-related diagnosis, stigmatizing language by physicians in clinical documentation was common and independently associated with comorbid polysubstance use and homelessness.
Derecho real de anticresis – revisión de la figura en el Código Civil y Comercial = Real right of antichresis - review of the figure in the Civil and Commercial Code
Authors: Marmissolle Guarisco Ronald Alfredo , Palomanes Ana María 
Published: October 2024

La ponencia la abordamos teniendo en cuenta la evolución del derecho real de anticresis en su concepción inicial, la recepción en el código civil y las modificaciones producidas en el reciente código civil y comercial; tratando las cuestiones referidas a: objeto de la anticresis; la llamada anticresis compensatoria o de riesgo; la cuestión atinente al privilegio en el Código Civil y La ley de Concursos y su armonización; el derecho de retención en la anticresis; los gastos útiles; la denominada anticresis tacita y los plazos de la anticresis.
ABSTRACT: We approach the presentation taking into account the evolution of the real right of antichresis in its initial conception, its reception in the civil code and the modifications produced in the recent civil and commercial code; dealing with the issues related to: object of antichresis; the so-called compensatory or risk antichresis; the issue regarding privilege in the Civil Code and the Bankruptcy Law and its harmonization; the right of retention in antichresis; useful expenses; the so-called tacit antichresis and the terms of antichresis.
Conservación del status civitatis y libertatis. El Caso de la Fictio Lex Cornelia y del ius postliminium = Conservation of the status civitatis and libertatis. The case of the Fictio Lex Cornelia and the ius postliminium
Authors: Rincón Ricardo Germán 
Published: October 2024

Las sociedades se organizan en base a sus premisas culturales. A partir de estas “estructuras mentales” organizan sus instituciones y su vida de relación, incluyendo entre éstas a sus normas jurídicas. La Fictio Lex Cornelia y el ius postlimium se inscriben dentro de esta lógica y traducen la respuesta a una necesidad existencial de los ciudadanos romanos
ABSTRACT: Societies are organized on the basis of their cultural premises. From these "mental structures" they organize their institutions and their relationship life, including their legal norms among these. The Fictio Lex Cornelia and the ius postlimium are inscribed within this logic and translate the response to an existential need of Roman citizens