bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptance and commitment therapy universal prevention program for adolescents: a feasibility study
Authors: Burckhardt Rowan , Manicavasagar Vijaya , Batterham Philip J. , Hadzi-Pavlovic Dusan , Shand Fiona 
Published: May 2017

AbstractBackgroundThere is a need to prevent anxiety and depression in young people and mindfulness contains important emotion regulation strategies. Acceptance and commitment therapy (ACT), a mindfulness-based therapy, has yet to be evaluated as a prevention program, but has demonstrated an ability to reduce symptoms of anxiety and depression in adult and adolescent populations. This study examines the feasibility of using an ACT-based prevention program in a sample of year 10 (aged 14–16 years) high school students from Sydney, Australia.MethodsParticipants were allocated to either their usual classes or to the ACT-based intervention. Participants were followed for a period of 5 months post-intervention and completed the Flourishing Scale, Depression Anxiety Stress Scale, and a program evaluation questionnaire. Analyses were completed using intention-to-treat mixed models for repeated measures.ResultsThe results indicated that the intervention was acceptable to students and feasible to administer in a school setting. There were no statistically significant differences between the conditions, likely due to the small sample size (N = 48). However, between-group effect sizes demonstrated small to large differences for baseline to post-intervention mean scores and medium to large differences for baseline to follow-up mean scores, all favouring the ACT-based condition.ConclusionThe results suggest that an ACT-based school program has potential as a universal prevention program and merits further investigation in a larger trial.Trial registrationAustralian New Zealand Clinical Trials Registry. Trial ID: ACTRN12616001383459. Registered 06/10/2016. Retrospectively registered.
Toward the reduction of incorrect drawn ink retrieval
Authors: Kitani Atsushi , Kimura Taketo , Nakatani Takako 
Published: May 2017

AbstractAs tablet devices become popular, various handwriting applications are used. Some of applications incorporate a specific function, which is generally called palm rejection. Palm rejection enables application users to put the palm of a writing hand onto a touch display. It classifies intended touches and unintended touches so that it prevents accidental inking, which has been known to occur under the writing hand. Though some of palm rejections can remove accidental inking afterward, this function occasionally does not execute correctly as it may remove rather correct ink strokes as well. We call this interaction Incorrect Drawn Ink Retrieval (IDIR). In this paper, we propose a software algorithm that is a combination of two palm rejection logics that reduces IDIR with precision and without latency. That algorithm does not depend on specific hardware, such as an active stylus pen. Our data provides 98.98% correctness and the algorithm takes less than 10 ms for the distinction. We confirm that our experimental application reduced the occurrences of IDIR throughout an experiment.
Fictionality Risen: Early America, the Common Core Curriculum, and How We Argue About Fiction Today
Authors: Koenigs Thomas 
Published: May 2017

AbstractThis article explores the recent popular press debates about the Common Core State Standards and their curricular mandates about the percentage of reading that can be fiction in middle school and high school curricula. I suggest that early American arguments about fiction’s educational value can help us better understand today’s debates about fiction’s role in the classroom, because they reveal just how much is taken for granted in our contemporary arguments about fiction. The article argues that recent work on fictionality (and on historical poetics generally) allows us to come to a richer understanding of the terms on which early Americans valued fiction, bringing into view a series of historical contestations over fictionality’s cultural meaning and purpose. These contestations, in turn, reveal just how delimited a sense of fiction’s value and possible uses underpins our current debates. After a brief reading of Royall Tyler’s The Algerine Captive (1797), the article explores how attention to these historical contestations over fiction’s value might lead to a reconsideration of the grounds on which we defend fiction’s educational value today. I close by considering the more general pedagogical implications of recent scholarship in historical poetics broadly construed.
Para sobreviver nas ondas do mercado
Authors: Olbermann Junia Vogel , Boff Daiane , Taufer Lucas 
Published: May 2017

Em 1978, Antônio e Maria decidiram largar a vida de empregados e abrir seu próprio negócio: uma confecção de roupas de cama. De lá para cá, as mudanças costuraram a vida da empresa. Mais de 30 anos depois, Joana, a atual proprietária e gerente, enfrenta um dilema: ela deve reinvestir no negócio para que este se mantenha competitivo? O objetivo deste caso consiste em ajudar Joana a decidir qual estratégia adotar nesste momento, a partir de informações setoriais, micro e macroeconômicas e de tendências de consumo.
The Dynamics of Borrower Reputation Following Financial Misreporting
Authors: Chava Sudheer , Huang Kershen , Johnson Shane A. 
Published: May 2017

We study the dynamics of borrower reputation in bank loan markets following revelations of financial misreporting by the borrower. Misreporting firms pay greater loan spreads than matched firms for at least six years following revelation of the misreporting, and there is no evidence of a downward trend in the misreporting premium. Following revelation, misreporting firms are more likely to engage in various actions to potentially rebuild their reputations, but even firms that engage in multiple actions continue to pay greater loan spreads for at least six years. Our results suggest that misreporting causes long-lasting and costly reputation losses that firms find very difficult or prohibitively costly to restore. Data and the online appendix are available at https://doi.org/10.1287/mnsc.2017.2739 . This paper was accepted by Wei Jiang, finance.
Normative Data for Critical Speed and D' for High-Level Male Rugby Players
Authors: Kramer Mark , Clark Ida E. , Jamnick Nick , Strom Cody , Pettitt Robert W. 
Published: May 2017

Abstract
Kramer, M, Clark, IE, Jamnick, N, Strom, C, and Pettitt, RW. Normative data for critical speed and D' for high-level male rugby players. J Strength Cond Res 32(3): 783–789, 2018—The critical speed (CS) concept helps characterize the aerobic and anaerobic fitness of an athlete. Rugby players should, hypothetically, have modest CS values but extremely high curvature constant (D') values, yet, normative data are currently unavailable. To develop normative data of CS and D' for high-level male rugby players, a total of 30 male rugby players were recruited from the Eastern Cape of South Africa. All subjects performed the running 3-minute all-out exercise test (3 MT) using global positioning system (GPS) technology to determine CS and D'. The GPS data were used to determine the total distance and velocities performed, and to examine for pacing effects. Summary statistics of mean ± SD are provided. High total running speeds for the initial 150 seconds (S
150s = 5.79 ± 0.59 m·s−1), and total distance (3 MT distance = 871.5 ± 71.9 m) were observed. A total of 13 of 30 subjects surpassed the 300 m D' value (mean D' = 288.2 ± 49.1 m). The CS of the total group was 3.87 ± 0.55 m·s−1. All 3 MT-derived data were categorized using standard nine (stanine) tables that allowed for the generation of normative data with which future performances, performances across similar sporting domains, and more accurate contrasts across the literature can be compared. Skewing of CS and D' was observed between forwards and backs, therefore, between-group differences in neither CS nor D' were observed (p > 0.05). Comparisons with previous literature indicate that male rugby players have higher CS values than female rugby players. When compared with Olympic distance runners, male rugby players have markedly higher D' values and markedly lower CS values. The 3 MT provides a useful procedure for assessing and prescribing high-intensity interval training for rugby athletes.
Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis
Authors: Mahdaviani Kiana , Benador Ilan Y , Su Shi , Gharakhanian Raffi A , Stiles Linsey , Trudeau Kyle M , Cardamone Maria , Enríquez‐Zarralanga Violeta , Ritou Eleni , Aprahamian Tamar , Oliveira Marcus F , Corkey Barbara E , Perissi Valentina , Liesa Marc , Shirihai Orian S 
Published: May 2017

AbstractBAT‐controlled thermogenic activity is thought to be required for its capacity to prevent the development of insulin resistance. This hypothesis predicts that mediators of thermogenesis may help prevent diet‐induced insulin resistance. We report that the mitochondrial fusion protein Mitofusin 2 (Mfn2) in BAT is essential for cold‐stimulated thermogenesis, but promotes insulin resistance in obese mice. Mfn2 deletion in mice through Ucp1‐cre (BAT‐Mfn2‐KO) causes BAT lipohypertrophy and cold intolerance. Surprisingly however, deletion of Mfn2 in mice fed a high fat diet (HFD) results in improved insulin sensitivity and resistance to obesity, while impaired cold‐stimulated thermogenesis is maintained. Improvement in insulin sensitivity is associated with a gender‐specific remodeling of BAT mitochondrial function. In females, BAT mitochondria increase their efficiency for ATP‐synthesizing fat oxidation, whereas in BAT from males, complex I‐driven respiration is decreased and glycolytic capacity is increased. Thus, BAT adaptation to obesity is regulated by Mfn2 and with BAT‐Mfn2 absent, BAT contribution to prevention of insulin resistance is independent and inversely correlated to whole‐body cold‐stimulated thermogenesis.
γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct
Authors: Ran Yong , Hossain Fokhrul , Pannuti Antonio , Lessard Christian B , Ladd Gabriela Z , Jung Joo In , Minter Lisa M , Osborne Barbara A , Miele Lucio , Golde Todd E 
Published: May 2017

Abstractγ‐Secretase inhibitors (GSIs) are being actively repurposed as cancer therapeutics based on the premise that inhibition of NOTCH1 signaling in select cancers is therapeutic. Using novel assays to probe effects of GSIs against a broader panel of substrates, we demonstrate that clinical GSIs are pharmacologically distinct. GSIs show differential profiles of inhibition of the various NOTCH substrates, with some enhancing cleavage of other NOTCH substrates at concentrations where NOTCH1 cleavage is inhibited. Several GSIs are also potent inhibitors of select signal peptide peptidase (SPP/SPPL) family members. Extending these findings to mammosphere inhibition assays in triple‐negative breast cancer lines, we establish that these GSIs have different functional effects. We also demonstrate that the processive γ‐secretase cleavage pattern established for amyloid precursor protein (APP) occurs in multiple substrates and that potentiation of γ‐secretase cleavage is attributable to a direct action of low concentrations of GSIs on γ‐secretase. Such data definitively demonstrate that the clinical GSIs are not biological equivalents, and provide an important framework to evaluate results from ongoing and completed human trials with these compounds.
GAD antibody-associated limbic encephalitis in a young woman with APECED
Authors: Kopczak Anna , Schumacher Adrian-Minh , Nischwitz Sandra , Kümpfel Tania , Stalla Günter K , Auer Matthias K 
Published: May 2017

Summary
The autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) syndrome is a genetic disorder caused by a mutation in the autoimmune regulator (AIRE) gene. Immune deficiency, hypoparathyroidism and Addison’s disease due to autoimmune dysfunction are the major clinical signs of APECED. We report on a 21-year-old female APECED patient with two inactivating mutations in the AIRE gene. She presented with sudden onset of periodic nausea. Adrenal insufficiency was diagnosed by means of the ACTH stimulation test. Despite initiation of hormone replacement therapy with hydrocortisone and fludrocortisone, nausea persisted and the patient developed cognitive deficits and a loss of interest which led to the diagnosis of depression. She was admitted to the psychiatric department for further diagnostic assessment. An EEG showed a focal epileptic pattern. Glutamic acid decarboxylase (GAD) antibodies, which had been negative eight years earlier, were now elevated in serum and in the cerebrospinal fluid. Oligoclonal bands were positive indicating an inflammatory process with intrathecal antibody production in the central nervous system (CNS). The periodic nausea was identified as dialeptic seizures, which clinically presented as gastrointestinal aura followed by episodes of reduced consciousness that occurred about 3–4 times per day. GAD antibody-associated limbic encephalitis (LE) was diagnosed. Besides antiepileptic therapy, an immunosuppressive treatment with corticosteroids was initiated followed by azathioprine. The presence of nausea and vomiting in endocrine patients with autoimmune disorders is indicative of adrenal insufficiency. However, our case report shows that episodic nausea may be a symptom of epileptic seizures due to GAD antibodies-associated LE in patients with APECED.

Learning points:

Episodic nausea cannot only be a sign of Addison’s disease, but can also be caused by epileptic seizures with gastrointestinal aura due to limbic encephalitis.

GAD antibodies are not only found in diabetes mellitus type 1, but they are also associated with autoimmune limbic encephalitis and can appear over time.

Limbic encephalitis can be another manifestation of autoimmune disease in patients with APECED/APS-1 that presents over the time course of the disease.
Pheochromocytomatosis associated with a novel TMEM127 mutation
Authors: Yu Run , Sharaga Danielle , Donner Christopher , Palma Diaz M Fernando , Livhits Masha J , Yeh Michael W 
Published: May 2017

Summary
Pheochromocytomatosis, a very rare form of pheochromocytoma recurrence, refers to new, multiple, and often small pheochromocytomas growing in and around the surgical resection bed of a previous adrenalectomy for a solitary pheochromocytoma. We here report a case of pheochromocytomatosis in a 70-year-old female. At age 64 years, she was diagnosed with a 6-cm right pheochromocytoma. She underwent laparoscopic right adrenalectomy, during which the tumor capsule was ruptured. At age 67 years, CT of abdomen did not detect recurrence. At age 69 years, she began experiencing episodes of headache and diaphoresis. At age 70 years, biochemical markers of pheochromocytoma became elevated with normal calcitonin level. CT revealed multiple nodules of various sizes in the right adrenal fossa, some of which were positive on metaiodobenzylguanidine (MIBG) scan. She underwent open resection of pheochromocytomatosis. Histological examination confirmed numerous pheochromocytomas ranging 0.1–1.2 cm in size. Next-generation sequencing of a panel of genes found a novel heterozygous germline c.570delC mutation in TMEM127, one of the genes that, if mutated, confers susceptibility to syndromic pheochromocytoma. Molecular analysis showed that the c.570delC mutation is likely pathogenic. Our case highlights the typical presentation of pheochromocytomatosis, a rare complication of adrenalectomy for pheochromocytoma. Previous cases and ours collectively demonstrate that tumor capsule rupture during adrenalectomy is a risk factor for pheochromocytomatosis. We also report a novel TMEM127 mutation in this case.

Learning points:

Pheochromocytomatosis is a very rare form of pheochromocytoma recurrence.

Pheochromocytomatosis refers to new, multiple and often small pheochromocytomas growing in and around the surgical resection bed of a previous adrenalectomy for a solitary pheochromocytoma.

Tumor capsule rupture during adrenalectomy predisposes a patient to develop pheochromocytomatosis.

Surgical resection of the multiple tumors of pheochromocytomatosis is recommended.

Pheochromocytoma recurrence should prompt genetic testing for syndromic pheochromocytoma.
Ultraprotective Ventilation during CPB Protects the Alveolar-Capillary Barrier in Pulmonary Normotensive Congenital Heart Patients
Authors: Gocen Ugur , Atalay Atakan 
Published: May 2017

Background: Alveolar-capillary membrane damage develops as a result of the inflammatory effect of cardiopulmonary bypass (CPB). In the presence of a healthy alveolar-capillary barrier, there is little or no surfactant in the blood. The aim of this study was to evaluate the protective effects of ultraprotective ventilation during CPB by measuring serum and bronchoalveolar lavage (BAL) surfactant protein B (SPB) values in congenital heart surgery.Methods: This prospective study was designed for 46 patients with congenital heart defects. Patients were classified into two groups: group 1 comprising pulmonary normotensive patients and group 2 consisting of pulmonary hypertensive (PH) patients. Each group was divided into two sub-groups: (a) those who received ultraprotective ventilation during CPB and (b) those who did not receive ultraprotective ventilation during CPB. Serum SPB (S-SPB) values were measured preoperatively (ST1); at the fourth hour postop (ST2); and at the 24th hour postop (ST3). BAL SPB values were measured preoperatively (BT1); and at the fourth hour postop (BT2). Results: ST1, ST2, and ST3 values of group 1a (pulmonary normotensive ventilated patients) and group 1b (pulmonary normotensive non-ventilated patients) were much lower than those of group 2a (pulmonary hypertensive ventilated patients) and group 2b (pulmonary hypertensive non-ventilated patients) (P < .05). The evaluation of ST1, ST2, and ST3 values between groups 1a and 1b did not show statistically significant differences. When comparing ST1 to ST3, a decrease in value was observed in group 1a (32.28 ± 13.27 ng/mL to 19.38 ± 7.6 ng/mL) (P = .006). In Group 1b, values increased between ST1 and ST2 before decreasing from ST2 to ST3; however, the ST3 values were still higher than their ST1 counterparts. It was recorded that there was no statistically significant difference between the ST1, ST2, and ST3 values of group 2a and group 2b. A comparison of the BT1 and BT2 values in groups also yielded no statistically significant differences. Conclusion: Although pulmonary hypertension is known to result in lung injury, this study is important as it shows that ultraprotective ventilation protects the alveolar-capillary barrier in pulmonary normotensive congenital heart patients.
Hybridity in the Vernacular: Nineteenth-Century Muslim Reform and Resistance
Authors: Khan Maryam Wasif 
Published: May 2017

[W]hat attracted Nussooh's immediate attention was a cabinet of books. There was a large collection of volumes; but whether Persian or Urdu, all were of the same kind, equally indecent and irreligious. Looking to the beauty of the binding, the excellence of the lithography, the fineness of the paper, the elegance of the style, and the propriety of the diction, Kulleem's books made a valuable library, but their contents were mischievous and degrading; and after Nussooh had examined them one by one, he resolved to commit them also to the flames.—Nazir Ahmad, The Repentance of NussoohIn the past twenty-five years, no theoretical conception has summed up the complexity of the colonial experience, and the possibilities of its interpretation, as well as Homi K. Bhabha's “hybridity.” “he sign of the productivity of colonial power,” but also the “name for the strategic reversal of the process of domination through disavowal,” hybridity exposes the uncomfortable state in which colonial culture settled and expanded and, today, continues to beleaguer the state of being “postcolonial” (Bhabha 112). Signiied by the “discovery of the book,” hegemony was marked by the miracle of an object that was at once authoritative and unknowable, one that the supposedly unlettered native could hold in reverent hands (102). In the dark space of the native's hands and narrated within a native register, however, the “colonial text emerges uncertainly” (107). he intent to civilize and anglicize a body of social, religious, and aesthetic practices in the colony, then, is adulterated, perhaps even unconsciously resisted, once it is disseminated by way of the seemingly irrefutable book.
The role of International sustainable development law principles in enabling effective renewable energy policy – a South African perspective.
Authors: Barnard Michelle 
Published: May 2017

It is universally accepted that renewable energy is an important contributing factor towards the promotion of sustainable development. The implementation of renewable energy needs to be regulated in an effective manner which in turn necessitates the formulation of law and policy geared towards sustainable development. Recent policy developments in South Africa propose to facilitate the promotion of sustainable development through the implementation of renewable energy, among others. In terms of existing energy policy in South-Africa, the interconnectivity of renewable energy and sustainable development is evident. Most notably, the White Paper on Renewable Energy of 2003 promotes increased access to affordable renewable energy in order to contribute to sustainable development. Moreover, the 2008 first review of the National Energy Efficiency Strategy of the Republic of South-Africa of 2005 states that in order for the country’s renewable energy policy to be considered sustainable, it needs to facilitate development in the social, economic and environmental spheres. Notwithstanding, attaining the goal of sustainable development depends on whether all its effecting principles are catered for in the policy developments. Accordingly, in order to ascertain whether South-African law and policy can successfully facilitate/enable sustainable development via the implementation of renewable energy, a specific methodology is proposed. In terms of the New Delhi Declaration of 2002 there are 7 principles of international law effecting sustainable development. These principles will be used as criteria in a principled assessment of South-African renewable energy law and policy in order to establish whether the goal of promoting sustainable development would be effected through the national policy developments.
Maternal outcome in thyroid dysfunction
Authors: K. Manju V. , K. Sathiamma P. 
Published: May 2017

Background: Thyroid hormone status in pregnancy is an important predictor of pregnancy outcome regarding both the mother and fetus. Objective was study the maternal outcome in antenatal women presenting with thyroid dysfunction.Methods: This descriptive study was done in 449 pregnant ladies who attended Obstetrics and Gynecology Department Government TD Medical College, Alappuzha, Kerala, India during the period January 2014 to June 2015. Aim was studying the maternal outcome in those diagnosed to have thyroid dysfunction evidenced by abnormal thyroid function tests (TFT) done in each trimester.Results: Majority had subclinical hypothyroidism (SCH). Common complications were preeclampsia spontaneous abortion, anemia and recurrent pregnancy loss. Infertility, post-partum hemorrhage and abruption were significantly high in overt hypothyroidism. Anemia was significantly high in subclinical hypothyroidism.Conclusions: It is important to screen all pregnant women for thyroid dysfunction during first antenatal visit itself to facilitate early diagnosis and treatment and also can counsel regarding the adverse pregnancy outcome.