bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EVOLUTION OF AN ENERGY CONTRARIAN
Authors: Linden Henry R. 
Published: July 2002

[Figure: see text] ▪ Abstract  An analysis of the forces that have shaped energy and energy-related environmental policies is presented through the eyes of an active participant in their evolution over the past 53 years. The problem of self-interest in taking energy and environmental policy positions is addressed candidly. The “energy crisis” is cited as an example. Its credibility depended on excessive demand projections, coupled with erroneous assessments of US and global hydrocarbon resources and of prospects for making these resources economically recoverable through technology advances. Many energy crisis proponents benefited from the misguided government response and from the large investments in uneconomic synthetic fuel technologies. Today, proponents of catastrophic anthropogenic climate change, again claiming scientific consensus, threaten to create even greater energy market distortions at large social and economic costs. The author traces his conversion to energy contrarian to the general failure of consensus and to his own misjudgments in these critical policy areas.
AUTONOMOUS SCIENCE AND SOCIALLY RESPONSIVE SCIENCE: A Search for Resolution
Authors: Brooks Harvey 
Published: July 2002

[Figure: see text] ▪ Abstract  I reflect on a career that has featured developing an advanced torpedo for submarine warfare during World War II, designing alternative nuclear reactors at the advent of nuclear power, guiding the development of the first institutions for technology assessment, assisting several of the early efforts at environmental policy analysis, and promoting experiments that have led to insights regarding the humanization of work. A recurring concern of mine, still unresolved, is how to give due weight, simultaneously, to two different visions of the scientific enterprise: an endeavor that must remain autonomous and an endeavor that must be driven by societal needs.
MECHANISMS OF PLANTVIRUS EVOLUTION
Authors: Roossinck Marilyn J. 
Published: July 2002

▪ Abstract  Plant viruses utilize several mechanisms to generate the large amount of genetic diversity found both within and between species. Plant RNA viruses and pararetroviruses probably have highly error prone replication mechanisms, that result in numerous mutations and a quasispecies nature. The plant DNA viruses also exhibit diversity, but the source of this is less clear. Plant viruses frequently use recombination and reassortment as driving forces in evolution, and, occasionally, other mechanisms such as gene duplication and overprinting. The amount of variation found in different species of plant viruses is remarkably different, even though there is no evidence that the mutation rate varies.The origin of plant viruses is uncertain, but several possible theories are proposed. The relationships between some plant and animal viruses suggests a common origin, possibly an insect virus. The propensity for rapid adaptation makes tracing the evolutionary history of viruses difficult, and long term control of virus disease nearly impossible, but it provides an excellent model system for studying general mechansims of molecular evolution.
TROPICAL PLANT PATHOLOGY: At Home and Abroad
Authors: Thurston H. David 
Published: July 2002

[Figure: see text] ▪ Abstract  I first describe my introduction to plant pathology and early experiences with employment, the environment, diseases, pests, and various plant pathologists. Then I recount a decade of stimulating studies at the University of Minnesota and the route I followed to a career in international agriculture with the Rockefeller Foundation in Colombia and later at Cornell University. My appreciation for and knowledge of traditional farmers and sustainable agriculture occurred as a slow awakening. Comments are made regarding problems, principles, and satisfactions associated with the improvement of efforts to aid food production in developing countries. My curious love affair with root and tuber crops, especially cassava, is explained and readily defended. My favorite pathogens, Phytophthora infestans and Ralstonia solanacearum, among others, are considered. The pleasures and satisfactions of teaching, writing, and sabbatical leaves are related. Finally, thoughts on the balance between basic and applied research in plant pathology are offered with significant nervousness about the future of our discipline.
Longitudinal Profiles of Semantic Impairment for Living and Nonliving Concepts in Dementia of Alzheimer's Type
Authors: Garrard Peter , Ralph Matthew A. Lambon , Watson Peter C. , Powis Jane , Patterson Karalyn , Hodges John R. 
Published: July 2002

Abstract
Two types of theoretical account have been proposed to explain the phenomenon of category-specific impairment in tests of semantic memory: One stresses the importance of different cortical regions to the representation of living and nonliving categories, while the other emphasize the importance of statistical relationships among features of concepts belonging to these two broad semantic domains. Theories of the latter kind predict that the direction of a domain advantage will be determined in large part by the overall damage to the semantic system, and that the profiles of patients with progressive impairments of semantic memory are likely to include a point at which an advantage for one domain changes to an advantage for the other. The present series of three studies employed semantic test data from two separate cohorts of patients with probable dementia of Alzheimer's type (DAT) to look for evidence of such a crossover. In the first study, longitudinal test scores from a cohort of 58 patients were examined to confirm the presence of progressive semantic deterioration in this group. In the second study, Kaplan-Meier survival curves based on serial naming responses and plotted separately for items belonging to living and nonliving domains indicated that the representations of living concepts (as measured by naming) deteriorated at a consistently and significantly faster rate than those of nonliving concepts. A third study, carried out to look in detail at the performance of mildly affected patients, employed an additional cross-sectional cohort of 20 patients with mild DAT and utilized a graded naming assessment. This study also revealed no evidence for a crossover in the advantage of one domain over the other as a function of disease severity. Taken together with the model of anatomical progression in DAT based on the work of Braak and Braak (1991), these findings are interpreted as evidence for the importance of regional cerebral anatomy to the genesis of semantic domain effects in DAT.
The Neural Substrate of Picture Naming
Authors: Murtha Susan , Chertkow Howard , Beauregard Mario , Evans Alan 
Published: July 2002

Abstract
A PET study of 10 normal males was carried out using the bolus H2 15O intravenous injection technique to examine the effects of picture naming and semantic judgment on blood flow. In a series of conditions, subjects (1) passively viewed flashing plus signs, (2) noted the occurrence of abstract patterns, (3) named animal pictures, or (4) carried out a semantic judgment on animal pictures. Anticipatory scans were carried out after the subjects were presented with the instructions but before they began the cognitive task, as they were passively viewing plus signs. Our results serve to clarify a number of current controversies regarding the neural substrate of picture naming. The results indicate that the fusiform gyrus is unlikely to be the region where low-level perceptual processing such as shape analysis is undertaken. In fact, our evidence suggests that activation of the fusiform gyrus is most likely related to visual perceptual semantic processing. In addition, the inferior/middle frontal lobe activity observed while performing the picture naming and semantic judgment tasks does not appear to be due to the effects of anticipation or preparation. Furthermore, there appears to be a set of regions (a semantic network) that becomes activated regardless of whether the subjects perform a picture naming or semantic judgment task. Finally, picture naming of animals did not activate either parietal regions or anterior inferior left temporal regions, regardless of what subtraction baseline was used.
Analyzing Holistic Parsers: Implications for Robust Parsing and Systematicity
Authors: Ho Edward Kei Shiu , Chan Lai Wan 
Published: July 2002

Holistic parsers offer a viable alternative to traditional algorithmic parsers. They have good generalization performance and are robust inherently. In a holistic parser, parsing is achieved by mapping the connectionist representation of the input sentence to the connectionist representation of the target parse tree directly. Little prior knowledge of the underlying parsing mechanism thus needs to be assumed. However, it also makes holistic parsing difficult to understand. In this article, an analysis is presented for studying the operations of the confluent pre-order parser (CPP). In the analysis, the CPP is viewed as a dynamical system, and holistic parsing is perceived as a sequence of state transitions through its state-space. The seemingly one-shot parsing mechanism can thus be elucidated as a step-by-step inference process, with the intermediate parsing decisions being reflected by the states visited during parsing. The study serves two purposes. First, it improves our understanding of how grammatical errors are corrected by the CPP. The occurrence of an error in a sentence will cause the CPP to deviate from the normal track that is followed when the original sentence is parsed. But as the remaining terminals are read, the two trajectories will gradually converge until finally the correct parse tree is produced. Second, it reveals that having systematic parse tree representations alone cannot guarantee good generalization performance in holistic parsing. More important, they need to be distributed in certain useful locations of the representational space. Sentences with similar trailing terminals should have their corresponding parse tree representations mapped to nearby locations in the representational space. The study provides concrete evidence that encoding the linearized parse trees as obtained via preorder traversal can satisfy such a requirement.
EX. XXXIII 7-11: EINE SYNCHRONE LEKTÜRE
Authors:   Barbiero
Published: July 2002

AbstractEntgegen der verbreiteten Meinung, Ex. xxxiii 7-11 sei eine "Digression" innerhalb von Kap. xxxiii, versucht der Verfasser, die Beziehungen dieses Textes zum Kontext zu erhellen. Das affallende Imperfekt der Verba findet in V. 6 ("vom Berg Horeb an") eine Erklärung. Mit dem folgenden Kontext sind V. 7-11 vor allem durch die Hervorhebung der Rolle des Mittlers verbunden. Barbiero sieht in Ex. xxxiii 7-11 eine Darstellung der prophetischen Rolle des Mose als Vermittler der Tora. Das "Zelt der Begegnung außerhalb des Lagers" bildet somit eine alternative und komplementäre Institution gegenüber dem priesterschriftlichen Tabernakel. In Kap. xxxiii werden aber die beiden Institutionen vorausgesetzt, was für eine sinnvolle Einheit auf der Ebene der Endredaktion nicht nur von Ex. xxxii-xxxiv, sondern der ganzen Sinaiperikope spricht.
Body size effects on pursuit success and interspecific diet differences in Cnemidophorus lizards
Authors: Passek Kelly , Eifler Douglas 
Published: July 2002

AbstractWe examined the relationship between body size and pursuit success in the lizard Cnemidophorus uniparens. Using grasshoppers as prey in experimental feeding trials, we found a significant positive relationship between lizard body size and pursuit time. In addition, larger individuals were significantly more likely to be unsuccessful at capturing the grasshoppers. We also examined the relationship between the mean body size of Cnemidophorus populations and diet composition. We found a significant negative relationship between mean body size and the proportion of grasshoppers in the diet and a significant positive relationship between mean body size and the proportion of termites in the diet.
Variation in mating pattern in a population of the Andean frog Hyla labialis
Authors: Lüddecke Horst 
Published: July 2002

AbstractUnmated frogs and mated pairs from a population of individually marked Hyla labialis were captured, measured and released over four consecutive years in a highland valley of the Colombian Andes. Across eight prolonged breeding seasons, three times more males than females were captured. On average, females were significantly larger than males. Although the largest reproductive males were larger than the smallest reproductive females, amplexing males were always smaller than the females they clasped. Larger males had no mating advantage, because the body size distribution of males was the same for mated and unmated males, and the average snout-vent length of mated males was similar to that of unmated males. There was no indication of larger males taking over clasped females during male-male competition, because there was no size difference between males clasping gravid, spawning and spent females. Significantly size-assortative matings occurred on days when male availability per female was moderately high, but not when it was low, suggesting that female mate choice is relatively more important than male-male competition in shaping mating pattern.
Infra-red studies of ammoniation of pillared montmorillonites
Authors: Witkowski S. , Sojka Z. , Dyrek K. , Fijał J. , Olkiewicz S. , Fink P. , Hobert H. 
Published: July 2002

AbstractAmmoniation of montmorillonites pillared with polyhydroxo-complexes of Al was performed in flow conditions at 773–1073 K and monitored by IR spectroscopy. Interaction of the clay with ammonia revealed exchange of terminal and bridging -OH groups by NH2-, NH- and N- species depending on the reaction temperature. Amination begins at 773 K while formation of NH groups starts at 873 K. Transformation of NH- into N-species occurs at 973 K. A mechanism for the ammoniation reaction is proposed and the series of the relative reactivity of OH groups was established: Si–OH > Mg–OH–Mg > Al–OH–Mg > Al–OH–Al. This series was rationalized in terms of accessibility of the OH groups.
Multiplex reverse transcriptase–polymerase chain reaction screening in childhood acute myeloblastic leukemia
Authors: Strehl Sabine , König Margit , Mann Georg , Haas Oskar A. 
Published: July 2002

Abstract
To determine the incidence of leukemia-specific rearrangements, 60 cases of childhood acute myeloblastic leukemia and transient myeloproliferative disorder were screened with a novel multiplex reverse transcriptase–polymerase chain reaction (RT-PCR) assay, and the results were correlated with the cytogenetic findings. The RT-PCR assay detects 28 different fusion genes and more than 80 different fusion transcript variants. RNA was isolated from methanol/acetic acid–fixed cells that had been routinely prepared for cytogenetic analysis. Nine different fusion transcripts were found in 40% of the cases, whereas 78.3% of the cases had abnormal karyotypes. Two cases with a t(6;11) and an MLL/AF6 gene fusion were missed cytogenetically. Conversely, cytogenetic analysis revealed 10 other well-defined chromosome rearrangements. Although cytogenetic analysis reveals a much broader range of abnormalities, multiplex RT-PCR serves as quality control and provides the essential information for minimal residual disease studies. Moreover, discrepant findings lead to the detection of new rearrangements on the molecular genetic level.
How I treat patients with von Willebrand disease
Authors: Mannucci Pier Mannuccio 
Published: July 2002

Abstract
Von Willebrand disease (vWD) is a frequent inherited disorder of hemostasis that affects both sexes. Two abnormalities are characteristic of the disease, which is caused by a deficiency or a defect in the multimeric glycoprotein called von Willebrand factor: low platelet adhesion to injured blood vessels and defective intrinsic coagulation owing to low plasma levels of factor VIII. There are 2 main options available for the treatment of spontaneous bleeding episodes and for bleeding prophylaxis: desmopressin and transfusional therapy with plasma products. Desmopressin is the treatment of choice for most patients with type 1 vWD, who account for approximately 70% to 80% of cases. This nontransfusional hemostatic agent raises endogenous factor VIII and von Willebrand factor 3 to 5 times and thereby corrects both the intrinsic coagulation and the primary hemostasis defects. In patients with the more severe type 3 and in most patients with type 2 disease, desmopressin is ineffective or is contraindicated and it is usually necessary to resort to plasma concentrates containing both factor VIII and von Willebrand factor. Concentrates treated with virucidal methods should be preferred to cryoprecipitate because they are equally effective and are perceived as safer.
Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen
Authors: Rizzieri David A. , Long Gwynn D. , Vredenburgh James J. , Gasparetto Christina , Morris Ashley , Stenzel Timothy T. , Davis Patti , Chao Nelson J. 
Published: July 2002

Abstract
Reduction in the toxicity of allogeneic transplantation with nonmyeloablative induction regimens has expanded the scope of practice to older and more debilitated patients. However, the limited availability of matched sibling donors requires that alternative donor sources be investigated. Reported here are 2 cases of patients with advanced hematologic malignancies without matched siblings, partially matched family members, or matched unrelated donors who successfully underwent nonmyeloablative conditioning therapy followed by infusion of partially matched, unrelated-donor cord blood cells. The patients are in remission and remain 100% donor as assessed by short tandem repeat analysis of the marrow 6 and 12 months following transplantation.
Medication Changes Among Older Drivers Involved in Motor Vehicle Crashes
Authors: Zullo Andrew R. , Riester Melissa R. , D’Amico Adam M. , Reddy Bhuma Monika , Khan Marzan A. , Curry Allison E. , Pfeiffer Melissa R. , Margolis Seth A. , Ott Brian R. , Bayer Thomas , Joyce Nina R. 
Published: October 2024

ImportanceAlthough older adults may use potentially driver-impairing (PDI) medications that can produce psychomotor impairment, little is known about changes to PDI medication use among older adults from the time before to the time after a motor vehicle crash (MVC).ObjectiveTo quantify use of and changes in PDI medications among older adults before and after an MVC.Design, Setting, and ParticipantsThis cohort study used linked Medicare claims and police-reported MVC data on 154 096 person-crashes among 121 846 older drivers. Eligible persons were drivers aged 66 years or older, involved in a police-reported MVC in New Jersey from May 1, 2007, through December 31, 2017, and with continuous enrollment in Medicare fee-for-service Parts A and B for at least 12 months and Part D for at least 120 days prior to the MVC. Data were analyzed from January 2022 to May 2024.Main Outcomes and MeasuresUse of benzodiazepines, nonbenzodiazepine hypnotics, opioid analgesics, and other PDI medications in the 120 days before and 120 days after the MVC. Because each person could contribute multiple MVCs during the study period if they met eligibility criteria, the unit of analysis was the number of person-crashes. The proportion of person-crashes after which PDI medications were started, discontinued, or continued was quantified as well.ResultsAmong 154 096 eligible person-crashes, the mean (SD) age of the drivers was 75.2 (6.7) years at the time of the MVC. Of 121 846 unique persons, 51.6% were women. In 80.0% of the person-crashes, drivers used 1 or more PDI medications before the crash, and in 81.0% of the person-crashes, drivers used 1 or more PDI medications after the crash. Use of benzodiazepines (8.1% before the crash and 8.8% after the crash), nonbenzodiazepine hypnotics (5.9% before the crash and 6.0% after the crash), and opioid analgesics (15.4% before the crash and 17.5% after the crash) was slightly higher after the MVC. After the MVC, drivers in 2.1% of person-crashes started benzodiazepines and 1.4% stopped benzodiazepines, drivers in 1.2% of person-crashes started nonbenzodiazepine hypnotics and 1.2% stopped nonbenzodiazepine hypnotics, and drivers in 8.4% of person-crashes started opioid analgesics and 6.3% stopped opioid analgesics.Conclusions and RelevanceThis cohort study suggests that most older drivers involved in MVCs did not use fewer PDI medications after crashes than before crashes. Qualitative research of perceived risks vs benefits of PDI medications is necessary to understand the reasons why MVCs do not appear to motivate clinicians to deprescribe PDI medications as a strategy to avert potential harms, including additional MVCs.
Comparative Effectiveness of Antipsychotics in Patients With Schizophrenia Spectrum Disorder
Authors: Hamina Aleksi , Taipale Heidi , Lieslehto Johannes , Lähteenvuo Markku , Tanskanen Antti , Mittendorfer-Rutz Ellenor , Tiihonen Jari 
Published: October 2024

ImportanceAntipsychotics are the cornerstone of maintenance treatment in schizophrenia spectrum disorders, but it is unclear which agents should be prioritized by prescribers.ObjectiveTo investigate the clinical effectiveness of antipsychotics, including recent market entries, in comparison with oral olanzapine in relapse and treatment failure prevention among individuals with schizophrenia spectrum disorder.Design, Setting, and ParticipantsThis comparative effectiveness research study with a within-individual analysis included data from Swedish health care registers of inpatient and specialized outpatient care, sickness absence, and disability pensions among all individuals aged 16 to 65 years who were diagnosed with schizophrenia spectrum disorder from January 1, 2006, to December 31, 2021, including an incident cohort and a prevalent cohort.ExposuresSpecific antipsychotics.Main Outcomes and MeasuresThe risks for psychosis relapse hospitalization and treatment failure (psychiatric hospitalization, death, or change in an antipsychotic medication) were adjusted for the temporal order of treatments, time since cohort entry, and concomitant drugs. Comparisons of all antipsychotics with oral olanzapine, the most commonly used antipsychotic, were investigated.ResultsAmong the full cohort of 131 476 individuals, the mean (SD) age of the study cohort was 45.7 (16.2) years (70 054 men [53.3%]). During a median follow-up of 12.0 years [IQR, 5.2-16.0 years], 48.5% of patients (N = 63 730) experienced relapse and 71.1% (N = 93 464) underwent treatment failure at least once. Compared with oral olanzapine, paliperidone 3-month long-acting injectable (LAI) was associated with the lowest adjusted hazard ratio (AHR) in the prevention of relapses (AHR, 0.66; 95% CI, 0.51-0.86), followed by aripiprazole LAI (AHR, 0.77 [95% CI, 0.70-0.84]), olanzapine LAI (AHR, 0.79 [95% CI, 0.73-0.86]), and clozapine (AHR, 0.82 [95% CI, 0.79-0.86]). Quetiapine was associated with the highest risk of relapse (AHR, 1.44 [95% CI, 1.38-1.51]). For prevention of treatment failure, paliperidone 3-month LAI was associated with the lowest AHR (AHR, 0.36 [95% CI, 0.31-0.42]), followed by aripiprazole LAI (AHR, 0.60 [95% CI, 0.57-0.63]), olanzapine LAI (AHR, 0.67 [95% CI, 0.63-0.72]), and paliperidone 1-month LAI (AHR, 0.71 [95% CI, 0.68-0.74]).Conclusions and RelevanceThis comparative effectiveness research study demonstrated large differences in the risk of relapse and treatment failure among specific antipsychotic treatments. The findings contradict the widely held conception that all antipsychotics are equally effective in relapse prevention.