bluuebunny/crossref_metadata_2025_split huggingface dataset:
The first MAXI/SSC catalog of X-ray sources in 0.7–7.0 keV
Authors: Tomida Hiroshi , Uchida Daiki , Tsunemi Hiroshi , Imatani Ritsuko , Kimura Masashi , Nakahira Satoshi , Hanayama Takanori , Yoshidome Koshiro 
Published: March 2016

Abstract
We present the first source catalog of the Solid-state Slit Camera (SSC) of the Monitor of All-sky X-ray Image (MAXI) mission on the International Space Station, using the 45-month data from 2010 August to 2014 April in the 0.7–7.0 keV bands. Sources are searched for in two energy bands, 0.7–1.85 keV (soft) and 1.85–7.0 keV (hard), the limiting sensitivity of 3 and 4 mCrab are achieved, and 140 and 138 sources are detected in the soft and hard energy bands, respectively. Combining the two energy bands, 170 sources are listed in the MAXI/SSC catalog. All but 2 sources are identified with 22 galaxies including AGNs, 29 cluster of galaxies, 21 supernova remnants, 75 X-ray binaries, 8 stars, 5 isolated pulsars, and 9 non-categorized objects. Comparing the soft-band fluxes at the brightest end in our catalog with the ROSAT survey, which was performed about 20 years ago, 10% of the cataloged sources are found to have changed flux since the ROSAT era.
4-Phenylbutyric Acid Reveals Good Beneficial Effects on Vital Organ Function via Anti–Endoplasmic Reticulum Stress in Septic Rats*
Authors: Liu Liangming , Wu Huiling , Zang JiaTao , Yang Guangming , Zhu Yu , Wu Yue , Chen Xiangyun , Lan Dan , Li Tao 
Published: March 2016

Objectives:Sepsis and septic shock are the common complications in ICUs. Vital organ function disorder contributes a critical role in high mortality after severe sepsis or septic shock, in which endoplasmic reticulum stress plays an important role. Whether anti–endoplasmic reticulum stress with 4-phenylbutyric acid is beneficial to sepsis and the underlying mechanisms are not known.Design:Laboratory investigation.Setting:State Key Laboratory of Trauma, Burns and Combined Injury.Subjects:Sprague-Dawley rats.Interventions:Using cecal ligation and puncture–induced septic shock rats, lipopolysaccharide-treated vascular smooth muscle cells, and cardiomyocytes, effects of 4-phenylbutyric acid on vital organ function and the relationship with endoplasmic reticulum stress and endoplasmic reticulum stress–mediated inflammation, apoptosis, and oxidative stress were observed.Measurements and Main Results:Conventional treatment, including fluid resuscitation, vasopressin, and antibiotic, only slightly improved the hemodynamic variable, such as mean arterial blood pressure and cardiac output, and slightly improved the vital organ function and the animal survival of septic shock rats. Supplementation of 4-phenylbutyric acid (5 mg/kg; anti–endoplasmic reticulum stress), especially administered at early stage, significantly improved the hemodynamic variables, vital organ function, such as liver, renal, and intestinal barrier function, and animal survival in septic shock rats. 4-Phenylbutyric acid application inhibited the endoplasmic reticulum stress and endoplasmic reticulum stress–related proteins, such as CCAAT/enhancer-binding protein homologous protein in vital organs, such as heart and superior mesenteric artery after severe sepsis. Further studies showed that 4-phenylbutyric acid inhibited endoplasmic reticulum stress–mediated cytokine release, apoptosis, and oxidative stress via inhibition of nuclear factor-κB, caspase-3 and caspase-9, and increasing glutathione peroxidase and superoxide dismutase expression, respectively.Conclusions:Anti–endoplasmic reticulum stress with 4-phenylbutyric acid is beneficial to septic shock. This beneficial effect of 4-phenylbutyric acid is closely related to the inhibition of endoplasmic reticulum stress–mediated oxidative stress, apoptosis, and cytokine release. This finding provides a potential therapeutic measure for clinical critical conditions, such as severe sepsis.
Cutaneous Manifestations of Familial Transthyretin Amyloid Polyneuropathy
Authors: Lanoue Julien , Wei Nancy , Gorevic Peter , Phelps Robert G. 
Published: March 2016

Abstract:
Familial amyloid polyneuropathy (FAP) is a rare inherited autosomal dominant form of systemic amyloidosis, which classically presents with severe motor, sensory, and autonomic dysfunction. Cutaneous involvement does not become clinically apparent until late stage symptomatic disease and is rarely reported in modern literature. Here, the authors review the clinical and histologic cutaneous findings of FAP previously described in the literature and report on 3 patients with unique genetic mutations (Thr60Ala and Gly6Ser; Trp41Leu; Glu89Gln) for which cutaneous involvement has not previously been described. Histologically, our patients showed variable amyloid deposition in the subcutaneous adipose tissue, papillary dermis, and dermal blood vessel walls. A review of the literature suggests cutaneous transthyretin deposition is an underrecognized feature of FAP that occurs early on in disease, even before neural involvement and related symptoms as seen in one of our patients. As such, a cutaneous punch biopsy can serve as quick, easy, and relatively noninvasive diagnostic tool in suspected cases.
Intravascular Myopericytoma of the Plantar Region: Case Report and Discussion of the Probable Origin From a Cutaneous Vascular Malformation
Authors: Agustí Jaime , Peñas Lucas , Bosch Nuria 
Published: March 2016

Abstract:
Myopericytoma is a perivascular myoid neoplasm of skin and soft tissues characterized by numerous thin-walled blood vessels surrounded concentrically by round to spindle myoid tumor cells, which shows α-smooth muscle actin and h-caldesmon coexpression and commonly negativity for desmin. These tumors arise predominantly in extremities of adult patients with benign clinical course. Based on the architectural pattern, there are various histologic variants as classical-solid myopericytoma, hemangiopericytoma-like myopericytoma, angioleiomyoma-like myopericytoma, myofibroma-like myopericytoma, hipocelular fibroma-like myopericytoma, intravascular myopericytoma, cellular immature myopericytoma, and malignant myopericytoma. The authors report a case that fully satisfies the morphological and immunohistochemical criteria for intravascular myopericytoma, which plantar location is not previously described in the literature. In addition, the authors discuss about its possible development from a preexistent cutaneous vascular malformation.
Cardiac Rehabilitation Prevents Recurrent Revascularization in Patients With Coronary Heart Disease
Authors: Hou Wen-Hsuan , Lai Chien-Hung , Jeng Chii , Hsu Chuan-Chih , Shih Chun-Ming , Tsai Pei-Shan 
Published: March 2016

PURPOSE:
To evaluate the effects of cardiac rehabilitation (CR) provided within the first 3 months of revascularization on reducing recurrent revascularization in patients with coronary heart disease in Taiwan.

METHODS:
In this population-based cohort study, we used the claims data of 1 million beneficiaries who were randomly selected from all beneficiaries enrolled in Taiwan's National Health Insurance program from 1996 to 2000. Between 2000 and 2007, 2838 patients underwent a first-event revascularization. Of these patients, 442 (15.6%) underwent CR within the first 3 months of admission for revascularization. The remaining 84.4% (n = 2396) served as the non-CR group. All the study patients were followed-up until the end of 2008 for any recurrent revascularization. A propensity score-adjusted Cox proportional hazard model was used to estimate the relative risk of recurrent revascularization associated with CR.

RESULTS:
During the 1- to 9-year follow-up, 69 patients (15.6%) in the CR group and 840 (35.1%) patients in the non-CR group experienced recurrent revascularization. The results of the propensity score-adjusted Cox proportional hazard regression analysis showed that CR was significantly associated with a reduced risk of recurrent revascularization with a hazard ratio of 0.48 (95% CI, 0.37 to −0.62).

CONCLUSIONS:
Cardiac rehabilitation within the first 3 months of revascularization is significantly associated with a reduced risk of recurrent revascularization. This preventive effect was more pronounced in men compared with other subgroups of patients.
Correlates of Exercise Self-efficacy in a Randomized Trial of Mind-Body Exercise in Patients With Chronic Heart Failure
Authors: Yeh Gloria Y. , Mu Lin , Davis Roger B. , Wayne Peter M. 
Published: March 2016

PURPOSE:
Exercise self-efficacy is one of the strongest predictors of physical activity behavior. Prior literature suggests that tai chi, a mind-body exercise, may increase self-efficacy; however, this is not extensively studied. Little is known about the factors associated with development of exercise self-efficacy in a population with heart failure.

METHODS:
We utilized data from a randomized controlled trial of 12 weeks of group tai chi classes versus education in patients with chronic heart failure (n = 100). Multivariable linear regression was used to explore possible correlates of change in exercise self-efficacy in the entire sample and in the subgroup who received tai chi (n = 50). Covariates included baseline quality of life, social support, functional parameters, physical activity, serum biomarkers, sociodemographics, and clinical heart failure parameters.

RESULTS:
Baseline 6-minute walk (β=−0.0003, SE = 0.0001, P = .02) and fatigue score (β= 0.03, SE = 0.01, P = .004) were significantly associated with change in self-efficacy, with those in the lowest tertile for 6-minute walk and higher tertiles for fatigue score experiencing the greatest change. Intervention group assignment was highly significant, with self-efficacy significantly improved in the tai chi group compared to the education control over 12 weeks (β= 0.39, SE = 0.11, P < .001). In the tai chi group alone, lower baseline oxygen uptake (β=−0.05, SE = 0.01, P = .001), decreased mood (β=−0.01, SE = 0.003, P = .004), and higher catecholamine level (epinephrine β= 0.003, SE = 0.001, P = .005) were significantly associated with improvements in self-efficacy.

CONCLUSIONS:
In this exploratory analysis, our initial findings support the concept that interventions like tai chi may be beneficial in improving exercise self-efficacy, especially in patients with heart failure who are deconditioned, with lower functional status and mood.
Predicting Peak Oxygen Uptake From the 6-Minute Walk Test in Patients With Pulmonary Hypertension
Authors: Zapico Augusto G. , Fuentes Darío , Rojo-Tirado Miguel A. , Calderón Francisco J. , Rosenzweig Erika B. , Garofano Robert P. 
Published: March 2016

PURPOSE:
To determine whether the 6-minute walk test (6MWT) is a predictor of peak oxygen uptake (

JOURNAL/jcprh/04.03/01273116-201605000-00008/8FSM1/v/2023-09-11T074048Z/r/image-gif

o
2) in patients with idiopathic pulmonary arterial hypertension (IPAH).

METHODS:
A total of 157 patients treated for IPAH completed a 6MWT in accordance with American Thoracic Society standards. Heart rate, pulse oximetry, and Borg rating of perceived exertion were determined at baseline and posttest. A cardiopulmonary exercise test (CPET) was performed on a cycle ergometer using a ramp protocol. Participants were stratified post hoc by age into 3 groups: children (n = 26), adolescents (n = 49), and adults (n = 82). Multiple linear regression analysis was performed to predict peak

JOURNAL/jcprh/04.03/01273116-201605000-00008/8FSM1/v/2023-09-11T074048Z/r/image-gif

o
2 from the 6MWT.

RESULTS:
The regression equation generated for the children was the only model to strongly predict peak

JOURNAL/jcprh/04.03/01273116-201605000-00008/8FSM1/v/2023-09-11T074048Z/r/image-gif

o
2 (r = 0.87; P < .001). Similar models for adolescent (r = 0.59; P < .001) and adult groups (r = 0.68; P < .001) did not achieve the same level of correlation.

CONCLUSION:
Six-Minute Walk Test was able to accurately predict peak

JOURNAL/jcprh/04.03/01273116-201605000-00008/8FSM1/v/2023-09-11T074048Z/r/image-gif

o
2 in children (6-12 years) with IPAH; however, the model was weaker for predicting peak

JOURNAL/jcprh/04.03/01273116-201605000-00008/8FSM1/v/2023-09-11T074048Z/r/image-gif

o
2 in older populations. These findings suggest that 6MWT may be as valid a test for predicting peak

JOURNAL/jcprh/04.03/01273116-201605000-00008/8FSM1/v/2023-09-11T074048Z/r/image-gif

o
2 in children with IPAH as CPET measured peak

JOURNAL/jcprh/04.03/01273116-201605000-00008/8FSM1/v/2023-09-11T074048Z/r/image-gif

o
2. In older IPAH populations, CPET is the only reliable method for the evaluation of peak

JOURNAL/jcprh/04.03/01273116-201605000-00008/8FSM1/v/2023-09-11T074048Z/r/image-gif

o
2.
FOCAL CHOROIDAL EXCAVATION AND CHOROIDAL NEOVASCULARIZATION WITH ASSOCIATED PACHYCHOROID
Authors: Ghadiali Quraish , Dansingani Kunal K. , Freund K. Bailey 
Published: March 2016

Purpose:
To report a case of focal choroidal excavation and choroidal neovascularization in the setting of pachychoroid disease.

Methods:
Multimodal imaging, including fundus photography, fundus autofluorescence, enhanced depth imaging optical coherence tomography, indocyanine green angiography, and en face structural and angiographic optical coherence tomography.

Results:
The authors describe a 39-year-old female with moderately high myopia presenting with focal choroidal excavation and associated choroidal neovascularization. Multimodal imaging demonstrated pachychoroid features with dilated choroidal vessels surrounding the lesion. Optical coherence tomography angiography showed Type 2 neovascularization.

Conclusion:
Some cases of focal choroidal excavation and associated neovascularization may be related to structural abnormalities of the associated choroidal vasculature.
Characteristics of Spirituality and Religion Among Suicide Attempters
Authors: Mandhouj Olfa , Perroud Nader , Hasler Roland , Younes Nadia , Huguelet Philippe 
Published: March 2016

Abstract
Spirituality and religiousness are associated with a lower risk of suicide. A detailed assessment of spirituality among 88 suicide attempters hospitalized after a suicide attempt was performed. Factors associated with the recurrence of suicide attempts over 18 months were looked into. Spirituality was low among most suicide attempters in comparison with the general population. Two groups were identified: those with a high score of depression who featured “low” in spirituality and those with a more heterogeneous profile, for example, involving personality disorders, characterized by a “high” spirituality. At the follow-up, the “meaning in life” score appeared to correlate with recurrence of suicide. Clinical implications are discussed herein.
Risk Factors for Venous Thromboembolism in Pediatric Trauma Patients and Validation of a Novel Scoring System: The Risk of Clots in Kids With Trauma Score*
Authors: Yen Jennifer , Van Arendonk Kyle J. , Streiff Michael B. , McNamara LeAnn , Stewart F. Dylan , Conner Kim G. , Thompson Richard E. , Haut Elliott R. , Takemoto Clifford M. 
Published: March 2016

Objectives:
Identify risk factors for venous thromboembolism and develop venous thromboembolism risk assessment models for pediatric trauma patients.

Design:
Single institution and national registry retrospective cohort studies.

Setting:
John Hopkins level 1 adult and pediatric trauma center and National Trauma Data Bank.

Patients:
Patients 21 years and younger hospitalized following traumatic injuries at John Hopkins (1987–2011). Patients 21 years and younger in the National Trauma Data Bank (2008–2010 and 2011–2012).

Interventions:
None.

Measurements and Main Results:
Clinical characteristics of Johns Hopkins patients with and without venous thromboembolism were compared, and multivariable logistic regression analysis was used to identify independent venous thromboembolism risk factors. Weighted risk assessment scoring systems were developed based on these and previously identified factors from National Trauma Data Bank patients (2008–2010); the scoring systems were validated in this cohort from Johns Hopkins and a cohort from the National Trauma Data Bank (2011–2012). Forty-nine of 17,366 pediatric trauma patients (0.28%) were diagnosed with venous thromboembolism after admission to our trauma center. After adjusting for potential confounders, venous thromboembolism was independently associated with older age, surgery, blood transfusion, higher Injury Severity Score, and lower Glasgow Coma Scale score. These and additional factors were identified in 402,329 pediatric patients from the National Trauma Data Bank from 2008 to 2010; independent risk factors from the logistic regression analysis of this National Trauma Data Bank cohort were selected and incorporated into weighted risk assessment scoring systems. Two models were developed and were cross-validated in two separate pediatric trauma cohorts: 1) 282,535 patients in the National Trauma Data Bank from 2011 to 2012 and 2) 17,366 patients from Johns Hopkins. The receiver operating curve using these models in the validation cohorts had area under the curves that ranged 90–94%.

Conclusions:
Venous thromboembolism is infrequent after trauma in pediatric patients. We developed weighted scoring systems to stratify pediatric trauma patients at risk for venous thromboembolism. These systems may have potential to guide risk-appropriate venous thromboembolism prophylaxis in children after trauma.
Predictors of Emergency Department Utilization Among Children in Vulnerable Families
Authors: Flood Colin , Sheehan Karen , Crandall Marie 
Published: March 2016

Background
Preventable visits to the emergency department (ED) are estimated to represent as much as 56% of overall annual ED utilization and contribute to the high cost of health care in the United States. There are more than 25 million annual pediatric ED visits.

Objective
The aim of this study was to identify factors associated with high ED utilization among children in vulnerable families.

Methods
The Fragile Families and Child Wellbeing Study is a longitudinal cohort of approximately 5000 vulnerable children. Data from the 9-year follow-up survey were used in this analysis. Bivariate and multivariate logistic regression analyses were performed to identify correlates with high ED utilization (≥4 visits per year).

Results
2631 children were included in the analysis. In a multivariate model controlling for the child’s sex, race, household income, and insurance status, 4 variables were significant predictors of ED utilization: history of hospitalization within the last year (odds ratio [OR], 15.97; 95% confidence interval [CI], 6.64–38.41; P < 0.001), diagnosis of asthma (OR, 2.53; 95% CI, 1.17–5.44; P = 0.02), number of child’s office/clinic visits within the last year (OR, 1.22; 95% CI, 1.12–1.33; P < 0.001), and number of primary caregiver ED visits within last year (OR, 1.15; 95% CI, 1.03–1.28; P = 0.01).

Conclusions
History of hospitalization, outpatient visits, primary caregiver ED utilization, and diagnosis of asthma independently predict high ED utilization by 9-year-old children in fragile families. Augmented continuity of care, disease management, and caregiver education may reduce high ED utilization in this population.
Safety of Terbutaline for Treatment of Acute Severe Pediatric Asthma
Authors: Doymaz Sule , Schneider James 
Published: March 2016

Objectives
The use of continuous intravenous terbutaline treatment in severe asthma attacks has been hampered by the lack of well-powered clinical trials where effects of such treatment are described in detail. Here, we aimed to provide a descriptive report on the largest cohort of severe pediatric asthma patients treated with terbutaline.

Methods
The study was conducted in a pediatric intensive care unit in a large metropolitan tertiary care university hospital on 124 patients receiving terbutaline infusion. To stratify the effect of, and determine any age-related differences of, terbutaline, the patients were divided into 3 age groups (0–6 years, 7–12 years, and 13–18 years). Clinical response and the potential harmful effects of terbutaline infusion were determined.

Results
There were significant reductions in systolic (varying between 86% and 93% of the baseline) and diastolic blood pressures (varying between 74% and 86% of the baseline level). However, the values returned to baseline level shortly after discontinuation of infusion. Terbutaline increased heart rates in all groups shortly after initiation (9%–13% above baseline), which returned to below baseline levels 1 hour after discontinuation. Serum potassium levels were also reduced in all patients compared to their baseline values after initiation of terbutaline infusion. However, none of the subjects required potassium replacement.

Conclusions
The results indicate that overall, terbutaline infusion was well tolerated without irreversible adverse effects of the treatment. Although hemodynamic and metabolic disturbances occurred, these were clinically easily managed and posed little risk in emergency department or pediatric intensive care unit.
A Knotted Urethral Catheter in the Emergency Department
Authors: Terentiev Victoria , Khentsinsky Ora , Dickman Eitan , Cortis Carmen , Arroyo Alexander 
Published: March 2016

Abstract
Inadvertent knotting of urethral catheters and enteric feeding tubes is a rare complication in pediatric patients. If a small flexible tube is used and advanced too far, upon withdrawal, the catheter may knot in the bladder. Surgical intervention for retrieval is required in most cases. We present a case of a 26-day-old female neonate who was catheterized with a 5 French enteric feeding tube, which was later removed in the emergency department with gentle traction alone. After removal, a knot was noted at the tip. It is important for emergency physicians to be aware of this complication, because this particular size feeding tube is most susceptible to kinking inside of the urinary tract.
Brief Report: HIV-1 Tropism During Primary Infections in France: 1996–2014
Authors: Raymond Stéphanie , Nicot Florence , Sauné Karine , Cazabat Michelle , Pasquier Christophe , Massip Patrice , Marchou Bruno , Delobel Pierre , Izopet Jacques 
Published: March 2016

Abstract:
HIV-1 was mainly CCR5 tropic in recent seroconverters. We analyzed the coreceptor use in 239 primary HIV-1 infections (PHIs) between 1996 and 2014 using a validated recombinant virus phenotypic entry assay. CXCR4-using viruses were detected in 8.3%, 3.8%, and 6.1% of PHIs from 1996 to 2004, 2005 to 2009, and 2010 to 2014, respectively. The presence of CXCR4-using viruses was associated with the virological failure of antiretroviral treatment initiated during PHI (odds ratio, 7.9; 95% confidence interval, 1.1 to 56.5). The phenotypic tropism assay data show that the prevalence of X4 tropic transmitted viruses was stable in this French cohort of PHIs between 1996 and 2014.