bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial/Ethnic Differences in Labor Induction in a Contemporary US Cohort: A Retrospective Cohort Study
Authors: Reddy Uma , Huang Chun-Chih , Driggers Rita , Landy Helain , Grantz Katherine , Singh Jasbir 
Published: October 2017

Objective To examine labor induction by race/ethnicity and factors associated with disparity in induction.
Study Design This is a retrospective cohort study of 143,634 women eligible for induction ≥24 weeks' gestation from 12 clinical centers (2002–2008). Rates of labor induction for each racial/ethnic group were calculated and stratified by gestational age intervals: early preterm (240/7–336/7), late preterm (340/7–366/7), and term (370/7–416/7 weeks). Multivariable logistic regression examined the association between maternal race/ethnicity and induction controlling for maternal characteristics and pregnancy complications. The primary outcome was rate of induction by race/ethnicity. Inductions that were indicated, non-medically indicated, or without recorded indication were also compared.
Results Non-Hispanic black (NHB) women had the highest percentage rate of induction, 44.6% (p < 0.001). After adjustment, all racial/ethnic groups had lower odds of induction compared with non-Hispanic white (NHW) women. At term, NHW women had the highest percentage rate (45.4%) of non-medically indicated or induction with no indication (p < 0.001).
Conclusion Compared with other racial/ethnic groups, NHW women were more likely to undergo non-medically indicated induction at term. As labor induction may avoid the occurrence of stillbirth, whether this finding explains part of the increased risk of stillbirth for NHB women at term merits further research.
Telemedizinische Assistenzsysteme in der Rehabilitation und Nachsorge –
Anwendungsbereiche und aktuelle Studienergebnisse
Authors: John M. , Einhaus J 
Published: October 2017

ZusammenfassungDie Angebote der medizinischen Rehabilitation müssen flexibler ausgestaltet, stärker auf die
individuellen Bedürfnisse der Betroffenen ausgerichtet und über die Sektorengrenzen hinweg
mit den angrenzenden Bereichen der Akutversorgung und der Nachsorge vernetzt werden. Um
diese Anforderungen erfüllen zu können, ist ein sinnvoller Einsatz Telemedizinischer
Assistenzsysteme sowohl in der eigentlichen Rehabilitations- als auch in der
anschließenden Nachsorgephase erforderlich. Nur dadurch können die angebotenen Leistungen
unter Wahrung einer hohen Behandlungsqualität auf Dauer bezahlbar gestaltet werden.Dieser Beitrag zeigt auf, in welchen Bereichen Telemedizinische Assistenzsysteme bereits
eingesetzt werden und welche Vorteile sich dadurch ergeben. Dabei wird jeweils sowohl für
die drei großen Bereiche der kardiologischen, neurologischen und orthopädischen
Rehabilitation als auch für sonstige Indikationen ein strukturierter Überblick zur
Studienlage geboten.
Herausnehmbare Implantatkonzepte bei Zahnlosen – Literaturübersicht
Authors: Brandstaeter Sebastian , Tschernitschek Harald , Pott Philipp-Cornelius 
Published: October 2017

ZusammenfassungKonzepte zur herausnehmbaren, implantatgetragenen Versorgung des zahnlosen Kiefers sind stetiger Bestandteil wissenschaftlicher Diskussionen. Dabei beschäftigen sich Experten und Fachgesellschaften in ihren Publikationen, Stellungnahmen und Leitlinien insbesondere mit der notwendigen Anzahl der Implantate, deren Positionierung im Kiefer und der Verwendung unterschiedlicher Verankerungselemente. Ziel dieser Arbeit war es, den derzeitigen Stand der relevanten Fachliteratur zusammenzufassen und bezüglich der Evidenzen zu beurteilen.
Liver Fat Content in People with Pituitary Diseases: Influence of Serum IGF1 Levels
Authors: Nguyen Amandine , Ricolfi Fréderic , Lemogne Brivel , Aho Serge , Lemaire Stéphanie , Bouillet Benjamin , Duvillard Laurence , Denimal Damien , Fourmont Coralie , Loffroy Romaric , Cercueil Jean , Verges Bruno , Petit Jean 
Published: October 2017

AbstractNon-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome, and type 2 diabetes. NAFLD is also seen in patients with endocrinopathies. However, the relationship between endocrine diseases and the development of NAFLD is not well known. In this study, we set out to determine whether liver fat content (LFC) was associated with IGF1 levels in people with pituitary diseases (PD). Eighty-nine patients with pituitary diseases and 74 healthy controls were included in this study. LFC was measured using MRI. Hepatic steatosis was defined as LFC>5.5%. Patients with PD were older, and had a higher BMI than healthy controls. LFC was significantly higher in people with PD than in controls (6.5% vs. 3.2%; p<0.001). LFC was negatively associated with the IGF1 level. The prevalence of steatosis was higher in PD patients than in controls (36.3% vs. 14.8%; p=0.002). In multivariate analysis, which included patients and controls, the predictive variables for steatosis were age, BMI and IGF1 levels, whereas the presence of pituitary diseases and gender were not associated with steatosis. Our data showed that LFC was strongly associated with IGF1 levels. These results suggest that steatosis associated with PD is probably a consequence of a low IGF1 level in these patients.
NTRC-dependent redox balance of 2-Cys peroxiredoxins is needed for optimal function of the photosynthetic apparatus
Authors: Pérez-Ruiz Juan Manuel , Naranjo Belén , Ojeda Valle , Guinea Manuel , Cejudo Francisco Javier 
Published: October 2017

Significance
Chloroplasts harbor a complex redox network formed by two systems, the FTR- thioredoxins (Trxs), which relies on photoreduced ferredoxin (Fd), and the NADPH-dependent Trx reductase C NTRC. Thus, an important issue in chloroplast biology is to establish the relationship between these redox pathways. Here we propose that the Fd-FTR-Trxs and NTRC redox systems are integrated via the redox balance of 2-Cys peroxiredoxins (Prxs), which therefore has a key role in chloroplast function. NTRC controls the redox balance of 2-Cys Prxs, which maintains the reducing capacity of the pool of chloroplast Trxs and, consequently, proper regulation of photosynthetic carbon assimilation enzymes. Therefore, redox regulation of chloroplast enzymes and hydrogen peroxide reduction are linked by the action of the NTRC-2-Cys Prxs system.
Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells
Authors: Haimovich Gal , Ecker Christopher M. , Dunagin Margaret C. , Eggan Elliott , Raj Arjun , Gerst Jeffrey E. , Singer Robert H. 
Published: October 2017

Significance
mRNA molecules convey genetic information within cells, beginning from genes in the nucleus to ribosomes in the cell body, where they are translated into proteins. Here we show a mode of transferring genetic information from one cell to another. Contrary to previous publications suggesting that mRNAs transfer via extracellular vesicles, we provide visual and quantitative data showing that mRNAs transfer via membrane nanotubes and direct cell-to-cell contact. We predict that this process has a major role in regulating local cellular environments with respect to tissue development and maintenance and cellular responses to stress, interactions with parasites, tissue transplants, and the tumor microenvironment.
Ultraaccurate genome sequencing and haplotyping of single human cells
Authors: Chu Wai Keung , Edge Peter , Lee Ho Suk , Bansal Vikas , Bafna Vineet , Huang Xiaohua , Zhang Kun 
Published: October 2017

Significance
Accurate sequencing and haplotyping of diploid genomes of single cells are intrinsically difficult due to the small amount of starting materials and limited read lengths of current DNA sequencing methods. In SISSOR (single-stranded sequencing using microfluidic reactors), we aim to improve sequencing accuracy and haplotype assembly by taking advantage of the redundant complementary sequence information in the double-stranded DNA and by partitioning megabase-size single-stranded DNA fragments from the homologous chromosome pairs into multiple compartments for amplification by MDA (multiple displacement amplification) and subsequent sequencing using short-read DNA sequencing platforms. We report the demonstration of the most accurate single-cell genome sequencing to date with data from three single human cells. Our approach can simultaneously provide higher accuracy and longer haplotypes than existing approaches.
Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis
Authors: Schreiber Adrian , Rousselle Anthony , Becker Jan Ulrich , von Mässenhausen Anne , Linkermann Andreas , Kettritz Ralph 
Published: October 2017

Significance
In this report, we provide evidence of a mechanistic link between antineutrophil cytoplasmic antibody (ANCA)-induced neutrophil activation, regulated necrosis (necroptosis), generation of neutrophil extracellular traps, complement activation, and endothelial cell damage with consecutive vasculitis and glomerulonephritis in autoimmune ANCA-induced vasculitis (AAV). We now show that inhibition of necroptosis-inducing kinases completely prevents ANCA vasculitis and establish a link to activation of the complement system. We suggest that these findings significantly extend our understanding of the pathogenesis of AAV and especially the tight regulation of neutrophil cell death therein. In addition, specific necroptosis inhibitors are currently being evaluated in clinical studies and can possibly complement existing therapeutic strategies in AAV.
Human hippocampal theta power indicates movement onset and distance travelled
Authors: Bush Daniel , Bisby James A. , Bird Chris M. , Gollwitzer Stephanie , Rodionov Roman , Diehl Beate , McEvoy Andrew W. , Walker Matthew C. , Burgess Neil 
Published: October 2017

Significance
Rodent hippocampal theta-band oscillations are observed throughout translational movement, implicating theta in the encoding of self-motion. Interestingly, increases in theta power are particularly prominent around movement onset. Here, we use intracranial recordings from epilepsy patients navigating in a desktop virtual reality environment to demonstrate that theta power is also increased in the human hippocampus around movement onset and throughout the remainder of movement. Importantly, these increases in theta power are greater both before and during longer paths, directly implicating human hippocampal theta in the encoding of translational movement. These findings help to reconcile previous studies of rodent and human hippocampal theta oscillations and provide additional insight into the mechanisms of spatial navigation in the human brain.
A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5′–3′ mRNA exonuclease in yeast
Authors: Charenton Clément , Gaudon-Plesse Claudine , Fourati Zaineb , Taverniti Valerio , Back Régis , Kolesnikova Olga , Séraphin Bertrand , Graille Marc 
Published: October 2017

Significance
Control of mRNA synthesis and decay is crucial for cells to adapt to their environment and for proper development. The 5′ end of eukaryotic mRNAs is modified by a structure called cap that protects them from rapid and uncontrolled decay. During mRNA decay, this cap is removed by a specialized and finely regulated multiprotein factory called decapping complex. Our results support a model in which the two major enzymes responsible for mRNA decapping (Dcp2) and decay (Xrn1) are sequentially recruited to mRNAs by the same surface from Pat1, a scaffolding protein central for decapping. As this Pat1 region is important for growth and specific to fungi, this is a potential target for the development of drugs against pathogenic yeasts.
Algorithm for cellular reprogramming
Authors: Ronquist Scott , Patterson Geoff , Muir Lindsey A. , Lindsly Stephen , Chen Haiming , Brown Markus , Wicha Max S. , Bloch Anthony , Brockett Roger , Rajapakse Indika 
Published: October 2017

Significance
Reprogramming the human genome toward any desirable state is within reach; application of select transcription factors drives cell types toward different lineages in many settings. We introduce the concept of data-guided control in building a universal algorithm for directly reprogramming any human cell type into any other type. Our algorithm is based on time series genome transcription and architecture data and known regulatory activities of transcription factors, with natural dimension reduction using genome architectural features. Our algorithm predicts known reprogramming factors, top candidates for new settings, and ideal timing for application of transcription factors. This framework can be used to develop strategies for tissue regeneration, cancer cell reprogramming, and control of dynamical systems beyond cell biology.
Framework and resource for more than 11,000 gene-transcript-protein-reaction associations in human metabolism
Authors: Ryu Jae Yong , Kim Hyun Uk , Lee Sang Yup 
Published: October 2017

Significance
Alternative splicing is a regulatory mechanism by which multiple protein isoforms can be generated from one gene. Despite its biological importance, there has been no systematic approach that facilitates characterizing functional roles of protein isoforms in human metabolism. To this end, we present a systematic framework for the generation of gene-transcript-protein-reaction associations (GeTPRA) in human metabolism. The framework involves a generic human genome-scale metabolic model (GEM) that is an excellent framework to investigate genotype–phenotype associations. We show that a biochemically consistent and transcript-level data-compatible human GEM can be used to generate GeTPRA, which can be deployed to further upgrade the human GEM. Personal GEMs generated with GeTPRA information enabled more accurate simulation of cancer metabolism and prediction of anticancer targets.
Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function
Authors: Duncan Ian D. , Marik Rachel L. , Broman Aimee T. , Heidari Moones 
Published: October 2017

Significance
The hallmark of remyelination in the CNS has been proposed to be the presence of thin myelin sheaths. This has been demonstrated in multiple experimental models and in multiple sclerosis. It is the only surrogate marker of remyelination, and therefore a crucial fingerprint of myelin repair. However, this has been challenged recently in separate studies, in which, by implication, the degree or presence of remyelinated axons has been underestimated. In this article, we provide evidence from two different models that thin myelin sheaths and short internodes persist almost indefinitely. Future attempts to promote myelin repair in models of multiple sclerosis will be crucially dependent on a definitive marker of repair. We propose that the thin myelin sheath remains the gold standard.
Group spike-and-slab lasso generalized linear models for disease prediction and associated genes detection by incorporating pathway information
Authors: Tang Zaixiang , Shen Yueping , Li Yan , Zhang Xinyan , Wen Jia , Qian Chen’ao , Zhuang Wenzhuo , Shi Xinghua , Yi Nengjun 
Published: October 2017

AbstractMotivationLarge-scale molecular data have been increasingly used as an important resource for prognostic prediction of diseases and detection of associated genes. However, standard approaches for omics data analysis ignore the group structure among genes encoded in functional relationships or pathway information.ResultsWe propose new Bayesian hierarchical generalized linear models, called group spike-and-slab lasso GLMs, for predicting disease outcomes and detecting associated genes by incorporating large-scale molecular data and group structures. The proposed model employs a mixture double-exponential prior for coefficients that induces self-adaptive shrinkage amount on different coefficients. The group information is incorporated into the model by setting group-specific parameters. We have developed a fast and stable deterministic algorithm to fit the proposed hierarchal GLMs, which can perform variable selection within groups. We assess the performance of the proposed method on several simulated scenarios, by varying the overlap among groups, group size, number of non-null groups, and the correlation within group. Compared with existing methods, the proposed method provides not only more accurate estimates of the parameters but also better prediction. We further demonstrate the application of the proposed procedure on three cancer datasets by utilizing pathway structures of genes. Our results show that the proposed method generates powerful models for predicting disease outcomes and detecting associated genes.Availability and implementationThe methods have been implemented in a freely available R package BhGLM (http://www.ssg.uab.edu/bhglm/).Supplementary informationSupplementary data are available at Bioinformatics online.
Managing public health data: mobile applications and mass vaccination campaigns
Authors: McClung Melissa W , Gumm Sarah A , Bisek Megan E , Miller Amber L , Knepper Bryan C , Davidson Arthur J 
Published: October 2017

Abstract
In response to data collection challenges during mass immunization events, Denver Public Health developed a mobile application to support efficient public health immunization and prophylaxis activities. The Handheld Automated Notification for Drugs and Immunizations (HANDI) system has been used since 2012 to capture influenza vaccination data during Denver Health’s annual employee influenza campaign. HANDI has supported timely and efficient administration and reporting of influenza vaccinations through standardized data capture and database entry. HANDI’s mobility allows employee work locations and schedules to be accommodated without the need for a paper-based data collection system and subsequent manual data entry after vaccination. HANDI offers a readily extensible model for mobile data collection to streamline vaccination documentation and reporting, while improving data quality and completeness.
In vitro activity of isavuconazole against fluconazole-resistant isolates of Histoplasma capsulatum
Authors: Spec Andrej , Connolly Patricia , Montejano Rocio , Wheat L Joseph 
Published: October 2017

Abstract
No clinical trials for histoplasmosis have been performed with the newer azoles, leaving itraconazole as the azole of choice. In vitro studies suggest that Histoplasma capsulatum from patients that relapse on fluconazole has higher minimum inhibitory concentrations (MICs) to fluconazole and voriconazole but not itraconazole and posaconazole. The newest azole, isavuconazole, shares structural similarity to voriconazole, but to date nobody has explored emergence of resistance. In vitro susceptibilities to isavucoanzole and fluconazole were performed on previously obtained isolates from the patients who relapsed on fluconazole therapy. Susceptibilities were determined by NCCLS method M27A developed for yeasts, as modified for H. capsulatum. The change in the MIC from the primary to the relapse isolate was tested using Wilcoxon Rank-Sum for paired data. Among the primary isolates, the median MICs were 1.0 (range 0.25 to 4.0) μg/ml for fluconazole and ≤0.007 (range ≤0.007 to 0.015) μg/ml for isavuconazole. In the group of relapsed isolates, the median MICs rose to 8.0 (range 0.25 to 64.0) μg/ml for fluconazole and remained unchanged at ≤0.007 (range ≤0.007 to 0.015) μg/ml for isavuconazole (P &lt; .001). Only one isolate exhibited a nonsignificant increase in MIC to isavuconazole. Histoplasma isolates from patients who relapsed on fluconazole did not have an elevation in MICs to isavuconazole. This differs from the results previously seen with voriconazole and suggests that despite a closer structural similarity to voriconazole than itraconazole and posaconazole, isavuconazole has a higher barrier to resistance and may be effective as therapy for histoplasmosis.
Off-axis short GRBs from structured jets as counterparts to GW events
Authors: Kathirgamaraju Adithan , Barniol Duran Rodolfo , Giannios Dimitrios 
Published: October 2017

Abstract
Binary neutron star mergers are considered to be the most favourable sources that produce electromagnetic (EM) signals associated with gravitational waves (GWs). These mergers are the likely progenitors of short duration gamma-ray bursts (GRBs). The brief gamma-ray emission (the ‘prompt’ GRB emission) is produced by ultrarelativistic jets, as a result, this emission is strongly beamed over a small solid angle along the jet. It is estimated to be a decade or more before a short GRB jet within the Laser Interferometer Gravitational-Wave observatory (LIGO) volume points along our line of sight. For this reason, the study of the prompt signal as an EM counterpart to GW events has been sparse. We argue that for a realistic jet model, one whose luminosity and Lorentz factor vary smoothly with angle, the prompt signal can be detected for a significantly broader range of viewing angles. This can lead to an ‘off-axis’ short GRB as an EM counterpart. Our estimates and simulations show that it is feasible to detect these signals with the aid of the temporal coincidence from a LIGO trigger, even if the observer is substantially misaligned with respect to the jet.
Predicting Smoking Lapses in the First Week of Quitting: An Ecological Momentary Assessment Study
Authors: Bolman Catherine , Verboon Peter , Thewissen Vivianne , Boonen Viviane , Soons Karin , Jacobs Nele 
Published: October 2017

Objectives:
This study focused on lapse shortly after an attempt to quit smoking. Ecological momentary assessment (EMA) studies have mapped real-time situational factors that induce lapses in everyday life. However, the possible role of nonsmoking intention is disregarded in the dynamic context of daily life, whereas intention plays a key role in behavior change and shifts during smoking cessation. This study therefore aimed to capture the influence of intention on lapse, next to the known risk factors of negative affect, low self-efficacy, craving, positive outcome expectations towards smoking (POEs), being around smokers, and stress. It is hypothesized that scores on these factors shift during the day, especially shortly after quitting, which may induce lapse. Based on behavioral explanation models, intention is hypothesized to mediate the influence of the mentioned factors on lapse.

Methods:
An EMA study was conducted among 49 self-quitters in the first week of smoking cessation.

Results:
Generalized Linear Mixed Model regression analyses revealed that low nonsmoking intentions, low self-efficacy, and being around smokers (estimates were, respectively, −0.303, −0.331, and 2.083) predicted lapse. Nonsmoking intention partially mediated the influence of self-efficacy on lapse. Nonsmoking intention was predicted by not being around smokers, high self-efficacy, and low POEs (estimates were, respectively, −0.353, 0.293, and −0.072).

Conclusions:
This small-scale EMA study confirms the importance of nonsmoking intention on lapse, next to self-efficacy and being around smokers. It adds insights into the mediating role of intention on the relationship between self-efficacy and lapse, and into the predictors of nonsmoking intention.