bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Vision for Fusion Energy Research: Fusion Rocket Engines for Planetary Defense
Authors: Wurden G. A. , Weber T. E. , Turchi P. J. , Parks P. B. , Evans T. E. , Cohen S. A. , Cassibry J. T. , Campbell E. M. 
Published: November 2015

Abstract

We argue that it is essential for the fusion energy program to identify an imagination-capturing critical mission by developing a unique product which could command the marketplace. We lay out the logic that this product is a fusion rocket engine, to enable a rapid response capable of deflecting an incoming comet, to prevent its impact on the planet Earth, in defense of our population, infrastructure, and civilization. As a side benefit, deep space solar system exploration, with greater speed and orders-of-magnitude greater payload mass would also be possible.
The pretransplant systemic metabolic profile reflects a risk of acute graft versus host disease after allogeneic stem cell transplantation
Authors: Reikvam Håkon , Hatfield Kimberley , Bruserud Øystein 
Published: November 2015

Abstract
Allogeneic stem cell transplantation is used in the treatment of younger patients with severe hematological diseases, especially hematological malignancies, and acute graft versus host disease (GVHD) is then an important immune-mediated posttransplant complication. Several risk factors for acute GVHD have been identified, including pretransplant factors that possibly influence the posttranspant course through their effects on host immunocompetent cells. Metabolic regulation is important for immunoregulation, and we therefore investigated whether the pretransplant metabolic status of allotransplant recipients was associated with later acute GVHD. In our population-based study we investigated the systemic (serum) metabolic profile for 86 consecutive allotransplant recipients. The samples were collected before start of the pretransplant conditioning therapy. Patients who developed later acute GVHD especially showed altered pretransplant amino acid metabolism, including (1) altered metabolism of immunoregulatory branched chain amino acids (leucine, isoleucine and valine); and (2) altered levels of potentially proinflammatory tyrosine metabolites (p-cresol sulphate, 3-phenylpropionate) formed by the gastrointestinal microbial flora. However, isobutyrylcarnitine and propyonylcarnitine levels were also altered; the carnitines are important for the transport of fatty acids and may also be important for the release of immunoregulatory cytokines in allotransplant recipients. These metabolic alterations were associated with an ongoing pretransplant acute phase reaction or early hematopoietic/immune reconstitution. Thus, allotransplant recipients developing acute GVHD showed altered preconditioning/pretransplant levels of several immunoregulatory metabolites. Our hypothesis is that these metabolites alter or activate recipient immunocompetent cells and thereby enhance or initiate anti-recipient immune reactivity.
Ranking very young Pinus radiata families for acoustic stiffness and validation by microfibril angle
Authors: Sharma Monika , Apiolaza Luis A. , Chauhan Shakti , Mclean J. Paul , Wikaira Jan 
Published: November 2015

Abstract

Key message

Acoustic techniques can be utilised to rank a large population of young trees for stiffness and stability for breeding purposes.

Introduction

This study sought to validate new approaches to rapid, very early screening and selection of radiata pine families, using microfibril angle (MFA) as a reference for comparative purposes.

Method

A key feature was tilting the trees at an angle of ∼30° after the initial 12 months of growth in order to force production of opposite wood (OW) and compression wood (CW) and prevent the co-mingling of the two distinctive wood types as occurs ‘at random’ within vertical stems. After 34 months, OW and CW materials were characterised independently for acoustic velocity (V), dynamic modulus of elasticity (MOEdynamic), basic density and longitudinal shrinkage. Finally, MFA were determined with X-ray diffraction.

Result

No phenotypic correlation was observed between OW and CW wood properties. The Spearman ranking correlation between V2 and MFA values in OW was 0.81.

Conclusion

We show that families or individual trees with superior wood properties can be screened at this young age using acoustics. Further, the same outcomes can be achieved as with X-ray diffraction (MFA) but more cheaply and rapidly.
Adjunctive use of interferon γ inducer for treatment of patients with schizophrenia
Authors: Vetlugina Tamara Parfenovna , Lobacheva Olga Anatolyevna , Sergeeva Svetlana Alexandrovna , Nikitina Valentina Borisovna , Nevidimova Tatiana Ivanovna , Semke Arkady Valentinovich 
Published: November 2015

ObjectiveThe present paper is devoted to evaluation of clinical and immunomodulatory effect of ultra-high dilutions of antibodies to human interferon γ, included in the complex therapy of patients with schizophrenia.Materials and methodsThe study was carried out at the Mental Health Research Institute, Tomsk, Russian Federation. This double-blind, placebo-controlled randomised in parallel-group study enrolled 40 patients. As a part of complex therapy, patients from the main group (n=20) received anaferon, a drug containing ultra-high dilutions of affinity-purified antibodies to human interferon γ as the active pharmaceutical ingredient; patients from the comparative group (n=20) received placebo. Duration of the therapy was 30±5 days. Assessment of severity of symptoms and changes in them were made using clinical scales: Positive and Negative Syndrome Scale, Clinical Global Impression, Abnormal Involuntary Movements Scale. Spontaneous and phytohemagglutinin-induced production of interferon γ by immunocompetent cells in supernatants of 48 h whole blood culture of patients was measured by enzyme-linked immunosorbent assay (ELISA) method.ResultsThe reduction of interferon-producing potential by immunocompetent cells in comparison with reference normal value was shown in total group of patients (n=40) before combined therapy. During the treatment, increase of spontaneous interferon γ production and favourable changes in psychopathological symptoms as compared with placebo were shown in subjects receiving anaferon. It was found that favourable changes in clinical symptoms assessed using clinical scales with a high degree of confidence correlated with high level of spontaneous interferon γ production.ConclusionAnaferon as a part of complex therapy of patients with schizophrenia contributes to enhancement of its efficacy acting via mechanism of psychoimmunomodulation.
Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
Authors: Park Eunyoung , Edirisinghe Indika , Choy Ying Yng , Waterhouse Andrew , Burton-Freeman Britt 
Published: November 2015

AbstractThe aim of the present study was to test grape seed extract (GSE) as a functional ingredient to lower blood pressure (BP) in individuals with pre-hypertension. A single-centre, randomised, two-arm, double-blinded, placebo-controlled, 12-week, parallel study was conducted in middle-aged adults with pre-hypertension. A total of thirty-six subjects were randomised (1:1) to Placebo (n18) or GSE (n18) groups; twenty-nine of them completed all the protocol-specified procedures (Placebo,n17; GSE,n12). Subjects consumed a juice (167 kJ (40 kcal)) containing 0 mg (Placebo) or 300 mg/d GSE (150 mg) twice daily for 6 weeks preceded by a 2-week Placebo run-in and followed by 4-week no-beverage follow-up. Compliance was monitored. BP was measured at screening, 0, 6 and 10 weeks of intervention and blood samples were collected at 0, 3, 6 and 10 weeks of intervention. GSE significantly reduced systolic BP (SBP) by 5·6 % (P=0·012) and diastolic BP (DBP) by 4·7 % (P=0·049) after 6 weeks of intervention period, which was significantly different (SBP;P=0·03) or tended to be different (DBP;P=0·08) from Placebo. BP returned to baseline after the 4-week discontinuation period of GSE beverage. Subjects with higher initial BP experienced greater BP reduction; nearly double the effect size. Fasting insulin and insulin sensitivity tended to improve after 6 weeks of GSE beverage supplementation (P=0·09 and 0·07, respectively); no significant changes were observed with fasting plasma lipids, glucose, oxidised LDL, flow-mediated dilation or vascular adhesion molecules. Total plasma phenolic acid concentrations were 1·6 times higher after 6 weeks of GSEv. Placebo. GSE was found to be safe and to improve BP in people with pre-hypertension, supporting the use of GSE as a functional ingredient in a low-energy beverage for BP control.
A prospective study of plasma 25-hydroxyvitamin D concentration and prostate cancer risk
Authors: Deschasaux Mélanie , Souberbielle Jean-Claude , Latino-Martel Paule , Sutton Angela , Charnaux Nathalie , Druesne-Pecollo Nathalie , Galan Pilar , Hercberg Serge , Le Clerc Sigrid , Kesse-Guyot Emmanuelle , Ezzedine Khaled , Touvier Mathilde 
Published: November 2015

AbstractMechanistic hypotheses suggest that vitamin D and the closely related parathyroid hormone (PTH) may be involved in prostate carcinogenesis. However, epidemiological evidence is lacking for PTH and inconsistent for vitamin D. Our objectives were to prospectively investigate the association between vitamin D status, vitamin D-related gene polymorphisms, PTH and prostate cancer risk. A total of 129 cases diagnosed within the Supplémentation en Vitamines et Minéraux Antioxydants cohort were included in a nested case–control study and matched to 167 controls (13 years of follow-up). 25-Hydroxyvitamin D (25(OH)D) and PTH concentrations were assessed from baseline plasma samples. Conditional logistic regression models were computed. Higher 25(OH)D concentration was associated with decreased risk of prostate cancer (ORQ4 v. Q1 0·30; 95 % CI 0·12, 0·77; Ptrend=0·007). PTH concentration was not associated with prostate cancer risk (Ptrend=0·4) neither did the studied vitamin D-related gene polymorphisms. In this prospective study, prostate cancer risk was inversely associated with 25(OH)D concentration but not with PTH concentration. These results bring a new contribution to the understanding of the relationship between vitamin D and prostate cancer, which deserves further investigation.
Decreasing the number of small eating occasions (<15 % of total energy intake) regardless of the time of day may be important to improve diet quality but not adiposity: a cross-sectional study in British children and adolescents
Authors: Murakami Kentaro , Livingstone M. Barbara E. 
Published: November 2015

AbstractEvidence of associations between meal frequency (MF) and snack frequency (SF) and diet and obesity in young populations is limited. This cross-sectional study examined MF and SF in relation to dietary intake and adiposity measures in British children aged 4–10 years (n 818) and adolescents aged 11–18 years (n 818). Based on data from a 7-d weighed dietary record, all eating occasions were divided into meals or snacks on the basis of contribution to energy intake (≥15 or <15 %) or time (06.00–10.00, 12.00–15.00 and 18.00–21.00 hours or others). All measures of MF and SF showed positive associations with energy intake, except for MF based on energy contribution in children. Irrespective of the definition of snacks, SF was associated with higher intakes of soft drinks, confectionery and total sugar, lower intakes of cereals, fish, meat, protein, PUFA, starch and dietary fibre, and a lower diet quality (assessed by the Mediterranean diet score, except for SF based on energy contribution in adolescents). MF based on time, but not based on energy contribution, was associated with higher intakes of confectionery and total sugar, lower intakes of fish, protein, PUFA and starch, and, only in children, a lower diet quality. All measures of MF and SF showed no association with adiposity measures. In conclusion, this cross-sectional study in British children and adolescents suggests that decreasing the number of small eating occasions (<15 % of total energy intake) regardless of the time of day may be important to improve diet quality but not adiposity.
A DEFENCE OF THE MARGIN OF APPRECIATION AND AN ARGUMENT FOR ITS APPLICATION BY THE HUMAN RIGHTS COMMITTEE
Authors: McGoldrick Dominic 
Published: November 2015

AbstractThe margin of appreciation (MoA) has become the central conceptual doctrine in the institutional and jurisprudential architecture of the European Convention on Human Rights (ECHR). This article critiques the existence and operation of the MoA within the ECHR system and defends its use. It is submitted that as each of the central justifications for the MoA under the ECHR applies equally to the International Covenant on Civil and Political Rights (ICCPR), so the doctrine should be applied by the Human Rights Committee.
Pre-operative counselling for laryngectomy patients: a systematic review
Authors: Fitzgerald E , Perry A 
Published: November 2015

AbstractObjectives:This study aimed to undertake a systematic review of the literature about pre-operative counselling for laryngectomy patients, identify its practice and patient and (where possible) carer perceptions.Methods:A search strategy was formulated using a concept map and a Population, Intervention, Comparative Interaction and Outcomes (‘PICO’) schema. All publications from 1975 to 2015 reporting pre-operative counselling of laryngectomy patients were included. Papers were retrieved and critiqued, and those included were assigned a level of evidence (according to the Joanna Briggs Institute schema).Results:Of the 56 papers retrieved, 21 were included in the review. The literature is limited: studies demonstrate bias and are of poor methodological quality. There are clear, persistent reports by patients and carers of shortfalls in clinical practice.Conclusion:Studies on pre-operative counselling for laryngectomees are flawed in design and represent weak levels of evidence. Pre-operative counselling has not been operationalised, resulting in differing paradigms being examined. Aggregation of data and/or results is not possible and the veracity of many studies is questioned.
Obliquity of the stapes in otosclerosis: intra-operative observations and implications in stapes surgery
Authors: Anand V , Udayabhanu H N 
Published: November 2015

AbstractObjective:To establish the prevalence of stapes obliquity as observed in otosclerosis patients during stapes surgery by a simple method of intra-operative measurement.Design:Prospective observational study.Results:Intra-operative measurements showed that the mean distance (± standard deviation) between the horizontal segment of the facial nerve and stapes crura in 10 cases of otosclerosis was 0.74 mm (± 0.21 mm), whereas in 10 cases of non-otosclerosis the same distance was 0.20 mm (± 0.00). There was no gap (0 mm) between the stapes crura and inferior border of the oval window niche in otosclerotic ears, whereas in non-otosclerotic ears the same distance was 0.13 mm (± 0.05 mm). The differences were statistically significant (p < 0.0001).Conclusion:Obliquity and downward displacement of the stapes occurs in otosclerosis. It has diagnostic value as a new clinical sign in otosclerosis. The findings correlate with late complications and failures in stapes surgery. Methods to avoid these have been suggested.
Plasma rotation with circularly polarized laser pulse
Authors: Lécz Z. , Andreev A. , Seryi A. 
Published: November 2015

AbstractThe efficient transfer of angular orbital momentum from circularly polarized laser pulses into ions of solid density targets is investigated with different geometries using particle-in-cell simulations. The detailed electron and ion dynamics presented focus upon the energy and momentum conversion efficiency. It is found that the momentum transfer is more efficient for spiral targets and the maximum value is obtained when the spiral step is equal to twice the laser wavelength. This study reveals that the angular momentum distribution of ions strongly depends up on the initial target shape and density.
Promoting City Leaders: The Structure of Political Incentives in China
Authors: Zuo Cai (Vera) 
Published: November 2015

AbstractThe shift in Beijing's priorities to more balanced and people-oriented development has led some localities to make more efforts in developing social policy areas. By investigating the personnel institution, a political incentive mechanism, this article aims to shed light on the structure of political incentives in China and why local political leaders improve public welfare in a non-democratic setting. A content analysis of 69 regulations that cover one-third of all municipal leaders shows that the formal evaluation rules for leaders in some localities have become more welfare-oriented to reflect Beijing's new focus on social policy areas. A statistical analysis further reveals that different political incentives operate for municipal Party leaders and mayors, and that political incentives to develop social policy vary across geographic regions. The statistical analysis exploits an original dataset I compiled from an online archive and statistical yearbooks, and contains biographic and career history data on municipal leaders between 2003 and 2010.
The OREMA Project: A call for the liberation of sound analysis
Authors: Gatt Michael 
Published: November 2015

Following Edgard Varèse’s influential lectures – translated and documented in ‘The Liberation of Sound’ – electroacoustic music has spawned many different styles and genres. His argument was for composers to follow their imagination and not be bound to the constraints of musical notation. This, arguably, was one of the catalysts for the emergence of electroacoustic musical works. With past and recent technological advancement, the varieties of genres and styles within electroacoustic music have only expanded, challenging the notion of how one could analyse such works. It is therefore unsurprising that there is no general consensus on analytical methodologies. But for an art form that celebrates all musical possibilities should the analysis of such musics be constraint to a set number of formalised analytical methodologies?Rather than propose a new all-encompassing methodology, this article will argue for a universal approach to electroacoustic music analysis and the liberation of sound analysis. The concept of an analytical community (a community that accepts multiple analyses whilst encouraging practitioners to find new and innovative ways to analyse such works) will be raised as a means to address the issues facing electroacoustic music analysis, using the OREMA (Online Repository for Electroacoustic Music Analysis) project as an example of such an initiative.
Economic evaluation of vitamin D and calcium food fortification for fracture prevention in Germany
Authors: Sandmann Arne , Amling Michael , Barvencik Florian , König Hans-Helmut , Bleibler Florian 
Published: November 2015

AbstractObjectiveThe study evaluates the economic benefit of population-wide vitamin D and Ca food fortification in Germany.DesignBased on a spreadsheet model, we compared the cost of a population-wide vitamin D and Ca food-fortification programme with the potential cost savings from prevented fractures in the German female population aged 65 years and older.SettingThe annual burden of disease and the intervention cost were assessed for two scenarios: (i) no food fortification; and (ii) voluntary food fortification with 20 µg (800 IU) of cholecalciferol (vitamin D3) and 200 mg of Ca. The analysis considered six types of fractures: hip, clinical vertebral, humerus, wrist, other femur and pelvis.SubjectsSubgroups of the German population defined by age and sex.ResultsThe implementation of a vitamin D and Ca food-fortification programme in Germany would lead to annual net cost savings of €315 million and prevention of 36 705 fractures in the target population.ConclusionsVitamin D and Ca food fortification is an economically beneficial preventive health strategy that has the potential to reduce the future health burden of osteoporotic fractures in Germany. The implementation of a vitamin D and Ca food-fortification programme should be a high priority for German health policy makers because it offers substantial cost-saving potential for the German health and social care systems.
Toxoplasma gondii: history and diagnostic test development
Authors: Wyrosdick Heidi M. , Schaefer John J. 
Published: November 2015

AbstractToxoplasma gondiiis a protozoa that causes toxoplasmosis in people and other animals. It is considered one of the most common parasitic infections in the world due to its impressive range of hosts, widespread environmental contamination and the diverse means by which animals can be infected. Despite its ubiquity and numerous ongoing research efforts into both its basic biology and clinical management, many aspects of diagnosis and management of this disease are poorly understood. The range of diagnostic options that is available for veterinary diagnostic investigators are notably more limited than those available to medical diagnosticians, making accurate interpretation of each test result critical. The current review joins other reviews on the parasite with a particular emphasis on the history and continued development of diagnostic tests that are useful for veterinary diagnostic investigations. An understanding of the strengths and shortcomings of current diagnostic techniques will assist veterinary and public health officials in formulating effective treatment and control strategies in diverse animal populations.
Just Between You and Me: Mutual Recognition Agreements and the Most-Favoured Nation Principle
Authors: ZELL JOSHUA A. 
Published: November 2015

AbstractMutual recognition agreements present unique legal issues in the application of the most-favoured nation obligations flowing from Article I:1 of GATT 1994 and Articles 2.1 and 5.1.1 of the TBT Agreement. Mutual recognition agreements come in two types – those recognizing the equivalence of technical regulations, and those recognizing the equivalence of conformity assessment procedures. Both carry potential trade advantages for state parties, but both also carry the potential to create unintended trade consequences for state parties if combined with a broad application of the most-favoured nation principle. The WTO Appellate Body has touched on a number of the relevant legal issues in a series of reports culminating in the May 2014EC–Sealsdecision, but many questions remain. This article seeks to provide states and practitioners with a guide to the issues and the way in which the Appellate Body would most likely address the remaining questions, based on the existing jurisprudence.