bluuebunny/crossref_metadata_2025_split huggingface dataset:
Audiologist perceptions of diagnosis and management of children with non-organic hearing loss (NOHL)
Authors: Stiles Derek J. 
Published: October 2017

Purpose:
About 7% of children between 6 and 17 years of age suffer from non-organic hearing loss (NOHL), yet little is known about how audiologists diagnose and manage this population. Audiologist appraisal of various approaches of evaluating children with NOHL was surveyed in order to determine which approaches are used most frequently and are perceived as most effective.

Method:
A web-based survey was distributed to audiologists working in pediatric centers and by word of mouth. Of 72 respondents, 61 submitted a complete survey. Analysis of the responses was performed to determine what term audiologists use when describing this population, which approaches are perceived as most effective and used most frequently, and what is the perceived role of the audiologist in managing this population.

Results:
As a whole, results were heterogeneous. The most used term to describe this presentation was ‘functional’ by 38% of respondents. The most effective approaches were restricted range, conditioned play, and reinstruction. The least effective approaches were behavioral observation, ear pointing, and counting beeps. Respondents primarily described the role of the audiologist as one of referral source back to the medical home or specialist.

Conclusion:
Overall responses to the survey were heterogeneous. This area may benefit from a practice statement that provides guidance on evaluating this population as well as further research on actual effectiveness of the test approaches (versus perceived).
The search environment is not (always) benign: reassessing the risks of organizational search
Authors: MacAulay Samuel C , Steen John , Kastelle Tim 
Published: October 2017

AbstractMarch and Simon’s (1958: 50) assumption that search happens within a “benign environment” has become taken-for-granted in organizational studies. The implications of making this assumption are not widely theorized, investigated, or even discussed, and yet, it often appears to have been unwittingly imported into explanations of organizational learning. March and Simon acknowledged that this assumption was not realistic—our work builds on theirs by investigating the origins and consequences of a non-benign search environment. We draw on in-depth qualitative research at a Fortune 500 mining firm to show how perceptions of social risk problematize the assumption of a benign search environment. Causal links are drawn between role equivalence, performance comparisons, and rivalry for social status to explain how social risk is generated and why it can lead actors to view the intraorganizational search environment as non-benign. These perceptions help create what we describe as a “paradox of local equivalence” that leads actors to search for nonlocal solutions. Our causal logic provides a new way of understanding the phenomena of nonlocal search; complements explanations of nonlocal search founded on myopia in organizational learning; and shows how the micro-foundations of existing search models can be adapted to better explain organizational learning. In doing so, this study contributes to recent efforts to improve behavioral explanations of search and learning by bringing the notion of intraorganizational conflict back to center stage in this important area of organizational theory.
Association of Insulin and Cholesterol Levels With Peripheral Nervous System Function in Overweight Adults: A 3-Year Follow-up
Authors: Isojärvi Henri , Keinänen-Kiukaanniemi Sirkka , Kallio Mika , Kaikkonen Kaisu , Jämsä Timo , Korpelainen Juha , Korpelainen Raija 
Published: October 2017

Purpose:
The purpose of this prospective 3-year follow-up was to investigate the association of glucose, insulin, and cholesterol levels with peripheral nervous system function in overweight and obese subjects.

Methods:
Forty nondiabetic overweight and obese adults were enrolled, of whom 29 completed the follow-up. Peripheral nervous system function was measured and defined by conduction studies of the peroneal motor nerve and the radial, sural, and medial plantar sensory nerves. Serum insulin and glucose levels were determined with an oral glucose tolerance test, and cholesterol levels were measured. The measurements were performed at baseline and after 3 years.

Results:
The change in serum insulin level at 120 minutes after an oral glucose tolerance test was positively associated with changes in peroneal nerve conduction velocities and F-wave mean, sural nerve conduction and medial plantar nerve conduction velocities. Action potential amplitudes decreased consistently and significantly in all sensory nerves.

Conclusions:
The change in serum insulin level at 120 minutes appears to be positively associated with changes in nerve conduction velocities more than 3 years but not with nerve action potential amplitudes. Significant decreases in the action potential amplitudes of all sensory nerves suggest that such changes might be the earliest detectable sign of damage to the peripheral nervous system in overweight and obese people without type 2 diabetes.
Gum Arabic promotes oxidation and ester hydrolysis
Authors: Vercruysse Koen P. , Tyler Lauren E. , Readus Jade 
Published: October 2017

AbstractWe studied the interactions between gum Arabic and select catecholic compounds like caffeic acid, chlorogenic acid and catechol. We observed that GA is capable of promoting the auto-oxidation of the above-mentioned compounds into darkly colored pigments without the addition of redox-sensitive cations. Gum Arabic appeared to be unique among polysaccharide-based materials as many other types of polysaccharides promote the oxidation of the above-mentioned compounds only in the presence of redox cations like Fe2+or Cu2+. RP-HPLC and SEC chromatographic techniques were employed to monitor the reactions and to observe the formation of high molecular mass, pigmented materials from gum Arabic and all three catecholic compounds. FT-IR spectroscopic analysis revealed that, despite their darkly colored appearances, the gum Arabic/pigment materials synthesized contain mostly gum Arabic and very little pigment. As chlorogenic acid is an ester of caffeic acid, we studied the capacity of gum Arabic to promote ester hydrolysis using acetylsalicylic acid as the model compound. We observed that gum Arabic did promote the hydrolysis of acetylsalicylic acid into salicylic acid. However, in all our experiments involving the pigment formation between gum Arabic and chlorogenic acid, we did not observe any evidence that chlorogenic acid was hydrolyzed leading to the release of caffeic acid during these reactions. In addition, we observed that heat treatment of gum Arabic did not affect its pro-oxidizing capability, but it did negatively affect its capability to hydrolyze salicylic acid. Thus, these two types of chemical reactivity present in the gum Arabic material may be associated with different components of the gum Arabic material.
Droplet-based microfluidic analysis and screening of single plant cells
Authors: Yu Ziyi , Boehm Christian R. , Hibberd Julian M. , Abell Chris , Haseloff Jim , Burgess Steven J. , Reyna-Llorens Ivan 
Published: October 2017

AbstractDroplet-based microfluidics has been used to facilitate high throughput analysis of individual prokaryote and mammalian cells. However, there is a scarcity of similar workflows applicable to rapid phenotyping of plant systems. We report on-chip encapsulation and analysis of protoplasts isolated from the emergent plant modelMarchantia polymorphaat processing rates of >100,000 protoplasts per hour. We use our microfluidic system to quantify the stochastic properties of a heat-inducible promoter across a population of transgenic protoplasts to demonstrate that it has the potential to assess gene expression activity in response to environmental conditions. We further demonstrate on-chip sorting of droplets containing YFP-expressing protoplasts from wild type cells using dielectrophoresis force. This work opens the door to droplet-based microfluidic analysis of plant cells for applications ranging from high-throughput characterisation of DNA parts to single-cell genomics.
Automatic detection of complex structural genome variation across world populations
Authors: Zhou Bo , Arthur Joseph G. , Guo Hanmin , Hughes Christopher R. , Kim Taeyoung , Huang Yiling , Pattni Reenal , Lee HoJoon , Ji Hanlee P. , Song Giltae , Palejev Dean , Zhu Xiang , Wong Wing H. , Urban Alexander E. 
Published: October 2017

ABSTRACTComplex structural variants (cxSVs), e.g. inversions with flanking deletions or interspersed inverted duplications, are part of human genetic diversity but their characteristics are not well delineated. Because their structures are difficult to resolve, cxSVs have been largely excluded from genome analysis and population-scale association studies. To permit large-scale detection of cxSVs from paired-end whole-genome sequencing, we developed Automated Reconstruction of Complex Variants (ARC-SV) using a novel probabilistic algorithm and a machine learning approach that leverages the new Human Pangenome Reference Consortium diploid assemblies. Using ARC-SV, we resolved, across 4,262 human genomes spanning all continental super-populations, 8,493 cxSVs belonging to 12 subclasses. Some cxSVs with population-specific signatures are shared with Neanderthals. Overall cxSVs are significantly enriched in regions prone to recombination and germlinede novomutations. Many cxSVs mark phenotypic hotspots (each significantly associated with ≥ 20 traits) identified in genome-wide association studies (GWAS), and 46.4% of all significant GWAS-SNPs catalogued to date reside within ±125 kb of at least one cxSV locus. Common SNPs near cxSVs show significant trait heritability enrichment. Genomic regions affected by cxSVs are enriched for bivalent chromatin states. Rare cxSVs are enriched in neural genes and loci undergoing rapid or accelerated evolution and recently evolvedcis-regulatory regions for human corticogenesis. We also identified 41 fixed loci where divergence from our most recent common ancestor is via localized cxSV. Our method and analysis framework allow for the accurate, efficient, and automatic identification of cxSVs for future population-scale studies of human disease and genome biology.
Executive influence on invention and commercialization
Authors: Sharp Barton M. , Iyer Dinesh N. , Brush Thomas H. 
Published: October 2017

Purpose
The purpose of this paper is to expand the understanding of the “front end” of innovation by examining the influence of top executives, who allocate the resources and cultivate the culture in which inventions are born, on the innovation process.

Design/methodology/approach
This paper suggests that the effect of executives on innovation can be better understood by explicitly separating innovation into the component processes of invention and commercialization. This allows us to consider how executive characteristics might have a different effect on technology development outcomes than they do on the subsequent transformation of those technologies into new products. The theory is tested on a sample of firms from the biomedical device industry.

Findings
The findings indicate that top management team (TMT) age and tenure have no effect on the type of technologies a firm develops (radical vs incremental) but do significantly affect the efficiency with which new technologies are turned into new products in some contexts. TMT heterogeneity affects both the type of technologies developed in the firm and also their transformation to new products. Interestingly, the effect of executives on commercialization depends on the type of underlying technologies which the firm has developed.

Originality/value
This paper contributes to the literatures on TMTs and innovation by offering a more granular explanation of how executives differentially impact the disaggregated stages of the innovation process, and thus also contributes to knowledge of the long-term innovation performance implications of executive leadership.
Categorization of control measures in food safety management systems
Authors: Politis Yannis , Krokos Fragoulis D. , Papadakis Ioannis 
Published: October 2017

Purpose
All food safety management standards require effective control measures of food safety hazards in order to ensure that food is safe at the time of human consumption. Furthermore, ISO 22000:2005 requires a logical approach to be carried out for the selection and categorization of the control measures according to the level of effect on identified food safety hazards. The purpose of this paper is to describe the COntrol MEasures CATegorization (COMECAT) method for the categorization of control measures in food safety management systems (FSMS) in order to assist organizations to prioritize and deploy their efforts and limited resources mainly to control significant hazards.

Design/methodology/approach
A thorough clarification of the characteristics of the different control measures used in FSMS has been achieved based on the definitions and the descriptions given by the different food safety standards such as the ISO 22000, the IFS and the BRC standards. The basic approaches for the determination of control measures found in literature and web pages have been examined and the proposed methodology has been implemented in feta cheese production in order to evaluate its applicability.

Findings
A decision tree model has been proposed as the most suitable approach for the categorization of control measures in FSMS. The implementation of the proposed COMECAT method in feta cheese production revealed its applicability. The method was able to identify the different risk level of food hazards and prioritize and deploy the organization’s efforts and limited resources for their management accordingly.

Originality/value
In the literature, there is a lack of justified methodologies for the categorization of control measures in FSMS. Most of the approaches concern attempts of private companies operating in the food industry or business consultancies and which can be found in their web pages. This paper describes a well-justified model for the categorization of control measures which is easy to implement and which results in more robust decisions.
Audit results of UK meat companies – critical analysis
Authors: Kotsanopoulos Konstantinos Vassilios , Arvanitoyannis Ioannis S. 
Published: October 2017

PurposeThe purpose of this paper is to analyze the results of several food safety audits carried out by the Food Standards Agency in meat and poultry-processing companies and slaughterhouses in the UK and audits in aquacultures carried out by the Aquaculture Stewardship Council and the Marine Scotland.Design/methodology/approachSpecifically, both a quantitative and a qualitative review were carried out.FindingsIt was revealed that in meat and poultry companies, the highest average proportion of major non-conformities (MNCs) within the total number of companies was recorded in slaughterhouses, while based on the type of product, the corresponding percentage of MNCs was found in poultry companies. Both in meat/poultry companies and aquacultures, small-sized companies presented the highest average percentage of MNCs. It was also revealed that a very high percentage of MNCs and minor non-conformities were recorded in relation to “record keeping.”Research limitations/implicationsThe limitations of the present study can be summarized into the fact that although a high number of audit reports were taken into account, and record keeping and past actions were reviewed as part of the audits, the audit represents only a snapshot in time and can heavily depend on the skills of the auditors.Originality/valueTo the best of the authors’ knowledge, there is very limited literature available that analyzes the results of audits and looks for trends in the food industry in the UK. The conclusions of this study can be of significant value to both the auditors and the industry by enabling a more targeted approach in the conduction of audits.
An integrated model for factors affecting construction and demolition waste management in Iran
Authors: Nikmehr Bahareh , Hosseini M. Reza , Rameezdeen Raufdeen , Chileshe Nicholas , Ghoddousi Parviz , Arashpour Mehrdad 
Published: October 2017

Purpose
Factors influencing management of construction and demolition (C&D) waste within the Iranian context have yet to be investigated. The purpose of this paper is to define and address this knowledge gap, through development of a model to map the associations among the primary factors affecting C&D waste at project, industry and national levels.

Design/methodology/approach
A conceptual model is developed based on synthesising the findings of available studies on factors affecting C&D waste with a focus on developing countries. For collecting data, the study drew upon a questionnaire survey of 103 Iranian construction practitioners. The strength and significance of associations among these factors to modify and validate the model were assessed using the structural equation modelling-partial least squares approach.

Findings
Major factors affecting C&D waste management and their level of importance were identified at project, industry and national levels. Results clearly showed that the government should review regulations pertaining to C&D waste management and make sure they are implemented properly. The “polluter pays principle” is a useful guide in devising effective policies and regulations for the Iranian context.

Originality/value
This study contributes to the field through presenting the first major study on C&D waste management in Iran. The study provides a picture of C&D waste management status quo in Iran and encapsulates the factors affecting C&D waste management in the Iranian context at different levels within an integrated model. The findings have practical implications for policy makers and construction practitioners in Iran, similar developing economies and foreign firms planning to operate in Iran.
Building information modelling for facility management: are we there yet?
Authors: Edirisinghe Ruwini , London Kerry Anne , Kalutara Pushpitha , Aranda-Mena Guillermo 
Published: October 2017

PurposeBuilding information modelling (BIM) is increasingly being adopted during construction projects. Design and construction practices are adjusting to the new system. BIM is intended to support the entire project life-cycle: the design and construction phases, and also facility management (FM). However, BIM-enabled FM remains in its infancy and has not yet reached its full potential. The purpose of this paper is to identify major aspects of BIM in order to derive a fully BIM-enabled FM process.Design/methodology/approachIn total, 207 papers were classified into main and subordinate research areas for quantitative analysis. These findings were then used to conceptualise a BIM-enabled FM framework grounded by innovation diffusion theory for adoption, and for determining the path of future research.FindingsThrough an extensive literature review, the paper summarises many benefits and challenges. Major aspects of BIM are identified in order to describe a BIM-enabled FM implementation process grounded by innovation diffusion theory. The major research areas of the proposed framework include: planning and guidelines; value realisation; internal leadership and knowledge; procurement; FM; specific application areas; data capture techniques; data integration; knowledge management; and legal and policy impact. Each element is detailed and is supported by literature. Finally, gaps are highlighted for investigation in future research.Originality/valueThis paper systematically classifies and evaluates the existing research, thus contributing to the achievement of the ultimate vision of BIM-enabled FM. The proposed framework informs facility managers, and the BIM-enabled FM implementation process. Further, the holistic survey identifies gaps in the body of knowledge, revealing avenues for future research.
Organizational culture influence on client involvement
Authors: Trigunarsyah Bambang 
Published: October 2017

Purpose
Lack of client involvement in construction of public projects has been identified as the main cause of many operational problems. Organizational culture (OC) plays a major role in guiding and shaping behavior of organizations, which could lead to the lack of client involvement. The purpose of this paper is to investigate the influence of OC on client’s involvement in construction project delivery.

Design/methodology/approach
A questionnaire survey was distributed to various government agencies of the Kingdom of Saudi Arabia. Structural equation modeling is used to determine the significance of the impact of OC factors on the involvement of clients in construction projects.

Findings
This study suggests that OC plays a major role in influencing and increasing the client involvement in construction projects by emphasizing team orientation, which includes team contribution and team accountability. In addition, it is also important to value employee’s idea.

Research limitations/implications
This study was limited to government agencies as clients in construction projects, i.e. only public sector construction projects (not private sector projects). Therefore, researchers are encouraged to investigate client involvement in the private sector projects.

Originality/value
This paper provides empirical evidence of the relationships between OC and the client involvement in construction projects by emphasizing team orientation.
Case study of “project controlling” on a large HOPSCA project in China
Authors: Wang Chun , Li Baiyi , Li Baizhan , Baldwin Andrew 
Published: October 2017

Purpose
The purpose of this paper is to present a detailed case study on the methods and organisational structure used for controlling the time schedule for a large and complex project. The paper discusses the use of “project controlling”, a term used to describe project control by a third-party organisation.

Design/methodology/approach
The researchers used action research to collect data for the case study. A member of the research team was a “participant-observer” on the project on a day-to-day basis for a period of 18 months collecting and analysing data which were subsequently analysed by a mixed methods approach.

Findings
The use of a “Project Controlling Unit” operated by an independent adviser organisation has significant advantages over traditional methods. It can provide timely, consolidated, independent guidance to the client and assistance to other participating organisations.

Research limitations/implications
The research has confirmed the effectiveness of the method on the project under study.

Practical implications
The findings provide guidance for enhanced project control on large complex infrastructural projects that will be of interest to other researchers, other clients and other construction organisations both within China and internationally.

Social implications
Organisations that seek to develop Project Controlling Units to implement the methods described in this paper will need to review their recruitment and training strategies to ensure that appropriate and experienced staffs are engaged.

Originality/value
The paper extends the knowledge relating to “project controlling” method. The findings provide additional insights to progress reporting and the management of construction production on HOPSCA and other large infrastructural projects.