bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term sequelae in survivors of childhood leukemia with Down syndrome: A childhood cancer survivor study report
Authors: Goldsby Robert E. , Stratton Kayla L. , Raber Shannon , Ablin Arthur , Strong Louise C. , Oeffinger Kevin , Sklar Charles A. , Armstrong Gregory T. , Robison Leslie L. , Bhatia Smita , Leisenring Wendy M. 
Published: November 2017

BACKGROUNDChildren with Down syndrome (DS) are at increased risk of developing acute leukemia and are more prone to acute toxicities. We studied the incidence and severity of chronic health conditions among survivors of childhood leukemia with DS compared with those without DS.METHODSChronic health conditions reported by questionnaire were compared between 154 pediatric leukemia survivors with DS and 581 without DS, matched by leukemia, age at diagnosis, race/ethnicity, sex, radiation location and chemotherapy exposure using Cox models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Subjects were selected from 7139 5‐year survivors of leukemia in the Childhood Cancer Survivor Study.RESULTSRisk of at least 1 late onset chronic health condition (grade 1‐5) was similar in the DS population compared with the non‐DS group (HR, 1.1; 95% CI, 0.7‐1.5). Serious chronic health conditions (grade 3‐5) were more common in DS survivors (HR, 1.7; 95% CI, 1.1‐2.6), as were ≥ 3 chronic health conditions (grades 1‐5) (HR, 1.7; 95% CI, 1.2‐2.4). The 25‐year cumulative incidence of any condition (grades 1‐5) was 83% for DS survivors and 69% for non‐DS survivors.CONCLUSIONLeukemia survivors with DS have therapy‐related chronic health conditions comparable to those of similarly treated survivors without DS, with a few notable exceptions: 1) an increased risk of cataracts, hearing loss, and thyroid dysfunction compared with survivors without DS (though these are known risks in the DS population), 2) decreased risk of second cancers, and 3) increased risk of severe or multiple conditions. Practitioners should be aware of these risks during and after therapy. Cancer 2018;124:617‐25. © 2017 American Cancer Society.
Reducing the number of response time service level objective violations by a cloud‐HPC convergence scheduler
Authors: Kraemer Alessandro , Maziero Carlos , Richard Olivier , Trystram Denis 
Published: November 2017

SummaryJob scheduling is an old topic in High‐Performance Computing (HPC), and it is more and more studied in data centers. Large data centers are often split into separate partitions for cloud computing and HPC; each partition normally has its specific scheduler. The possibility of migrating jobs from the HPC partition to the cloud one is a topic widely discussed in the literature. However, job migration from cloud to HPC is a much less explored topic. Nevertheless, such migration may be useful in many situations, in particular when the HPC platform has a low resource usage level, and the cloud usage level is high. A large number of jobs that could migrate from the cloud to the HPC partition may be observed in Google data center workloads. Job scheduling using overbooking strategy is seen as the main reason for the high resource usage level in clouds. However, overbooking can lead to a high rate of rescheduling and job dumping, which potentially causes response time violations. This work shows that HPC platforms can host and execute some cloud jobs with low interference in HPC jobs and a low number of response time violations. We introduce the definition of a cloud‐HPC convergence area and propose a job scheduling strategy for it, aiming at reducing the number of response time violations of cloud jobs without interfering with HPC jobs execution. Our proposal is formally defined and then evaluated in different execution scenarios, using the SimGrid simulation framework, with workload data from production HPC grid. The experimental results show that often, there is a large number of empty areas in the scheduling plan of HPC platforms, which makes it possible to allocate cloud jobs by backfilling. This is due to the sparse HPC job submission pattern and the low resource usage level in some HPC platforms. One performed simulation scenario considered a set of 11K parallel HPC jobs running on a 2560‐processor platform having an average resource usage level of 38.0%. The proposed convergence scheduler succeeded to inject around 267K cloud jobs in the HPC platform, with a response time violation rate under 0.00094% for such jobs, considering 80 processors in the convergence area and no effects on the HPC workload. This experiment considered cloud jobs based on job features of Google public cloud workloads, with a processing time slack factor of 1.25 (which is considered as high priority in the Google cloud SLA—Service Level Agreement). Usually, most cloud jobs show a slack factor higher than 1.25 (most cloud jobs are medium or low priority). The same simulation, repeated with a higher slack factor (4), showed no response time violations.
Sensor data management in the cloud: Data storage, data ingestion, and data retrieval
Authors: Sangat Prajwol , Indrawan‐Santiago Maria , Taniar David 
Published: November 2017

SummarySensors are widely used in the field of manufacturing, railways, aerospace, cars, medicines, robotics, and many other aspects of our everyday life. There is an increasing need to capture, store, and analyse the dynamic semi‐structured data from those sensors. A similar growth of semi‐structured data in the modern web has led to the creation of NoSQL data stores for scalability, availability, and performance, whereas large‐scale data processing frameworks for parallel analysis. NoSQL data store such as MongoDB and data processing framework such as Apache Hadoop has been studied for scientific data analysis. However, there has been no study on MongoDB with Apache Spark, and there is a limited understanding of how sensor data management can benefit from these technologies, specifically for ingesting high‐velocity sensor data and parallel retrieval of high volume data. In this paper, we evaluate the performance of MongoDB sharding and no‐sharding databases with Apache Spark, to identify the right software environment for sensor data management.
Preservation of Nuclear Spin Order by Precipitation
Authors: Eills James , Alonso‐Valdesueiro Javier , Salazar Marcano David E. , Ferreira da Silva Jesse , Alom Shamim , Rees Gregory J. , Hanna John V. , Carravetta Marina , Levitt Malcolm H. 
Published: November 2017

AbstractWe demonstrate that non‐equilibrium nuclear spin order survives precipitation from solution and redissolution. The effect is demonstrated on13C‐ and2H‐labeled sodium fumarate, with precipitation and dissolution achieved by altering the pH. The lifetime of the spin magnetization in the precipitate suspension is found to be much longer than in solution. Our preliminary results show an extension of the effective relaxation time T1for the metabolite fumarate by a factor of ≈6. We show that when the free radical agent TEMPO is present in the solution, it is not incorporated into the precipitate, suggesting that this procedure may provide a means to store and transport agents polarized by dynamic nuclear polarization. Although the relaxation time, T1, of the precipitate suspension is longer than that of the same molecules in solution, it is significantly shorter than that observed in the immobilized solid state.
Binder‐Free Hybrid Titanium–Niobium Oxide/Carbon Nanofiber Mats for Lithium‐Ion Battery Electrodes
Authors: Tolosa Aura , Fleischmann Simon , Grobelsek Ingrid , Quade Antje , Lim Eunho , Presser Volker 
Published: November 2017

AbstractFree‐standing, binder‐free, titanium–niobium oxide/carbon hybrid nanofibers are prepared for Li‐ion battery applications. A one‐pot synthesis offers a significant reduction of processing steps and avoids the use of environmentally unfriendly binder materials, making the approach highly sustainable. Tetragonal Nb2O5/C and monoclinic Ti2Nb10O29/C hybrid nanofibers synthesized at 1000 °C displayed the highest electrochemical performance, with capacity values of 243 and 267 mAh g−1, respectively, normalized to the electrode mass. At 5 A g−1, the Nb2O5/C and Ti2Nb10O29/C hybrid fibers maintained 78 % and 53 % of the initial capacity, respectively. The higher rate performance and stability of tetragonal Nb2O5 compared to that of monoclinic Ti2Nb10O29 is related to the low energy barriers for Li+ transport in its crystal structure, with no phase transformation. The improved rate performance resulted from the excellent charge propagation in the continuous nanofiber network.
One‐step Synthesis of AuAg Alloy Nanodots and its Electrochemical Studies towards Nitrobenzene Reduction and Sensing
Authors: Manivannan Shanmugam , Jeong Juwon , Kang Dong‐Ku , Kim Kyuwon 
Published: November 2017

AbstractEfficient, stable, and low‐cost electrocatalysts for the degradation and sensing of environment pollutants are essential components of clean environment monitoring. Here we report, one‐step synthesis and characterization of 1–3 nm diameter sized bi‐metallic AuAg nanodots (NDs) embedded in amine functionalized silicate sol‐gel matrix (SSG) and its electrochemical studies toward nitrobenzene. The SSG was used as a reducing agent as well as stabilizer for the prepared mono‐ and bi‐metallic nanoparticles (NPs). From the HRTEM, STEM‐EDS and XPS analyses, the bi‐metallic AuAg NDs were identified as an alloy and not the mixtures of Au and Ag NPs. Characteristic surface plasmon resonance (SPR) band between the Au and Ag NPs SPR absorption region was noticed for the prepared AuAg NDs. The AuAg alloy NDs with different concentrations of Au and Ag (Au25Ag75, Au50Ag50 and Au75Ag25 NDs) modified electrodes exhibited synergistic electrocatalytic effect than did the Au and Ag NPs towards nitrobenzene reduction and detection. Together with ultra‐small size and exceptional colloidal stability features within these SSG‐AuAg NDs pave convenient way for nanotechnology‐based catalysts development and sensor applications.
A modified 384‐well‐device for versatile use in 3D cancer cell (co‐)cultivation and screening for investigations of tumor biology in vitro
Authors: Widder Miriam , Lemke Karen , Kekeç Bünyamin , Förster Tobias , Grodrian Andreas , Gastrock Gunter 
Published: November 2017

AbstractPancreatic cancer exhibits a worst prognosis owed to an aggressive tumor progression i.a. driven by chemoresistance or tumor‐stroma‐interactions. The identification of candidate genes, which promote this progression, can lead to new therapeutic targets and might improve patient's outcome. The identification of these candidates in a plethora of genes requires suitable screening protocols. The aim of the present study was to establish a universally usable device which ensures versatile cultivation, screening and handling protocols of cancer cells with the 3D spheroid model, an approved model to study tumor biology. By surface modification and alternative handling of a commercial 384‐well plate, a modified device enabling (i) 3D cultivation either by liquid overlay or by a modified hanging drop method for (ii) screening of substances as well as for tumor‐stroma‐interactions (iii) either with manual or automated handling was established. The here presented preliminary results of cell line dependent dose‐response‐relations and a stromal‐induced spheroid‐formation of the pancreatic cancer cells demonstrate the proof‐of‐principle of the versatile functionality of this device. By adapting the protocols to automation, a higher reproducibility and the ability for high‐throughput analyses were ensured.
Extraction Rate and Energy Efficiency of Supercritical Carbon Dioxide Recovery of Higher Alcohols from Dilute Aqueous Solution
Authors: Tompsett Geoffrey A. , Boock Jason T. , DiSpirito Cameron , Stolz Eric , Knutson David R. , Rivard Allison G. , Overdevest Mark R. , Conlon Chelsea N. , Prather Kristala L. J. , Thompson Janelle R. , Timko Michael T. 
Published: November 2017

AbstractNew biotechnologies have been developed to produce higher alcohols, including various isomers of butanol, pentanol, and hexanol. The thermodynamic properties of higher alcohols—i.e., low volatility and moderate water solubility—make them good candidates for extraction using supercritical carbon dioxide (scCO2). Here, we studied semi‐batch extraction of several representative higher alcohols, including n‐butanol, n‐pentanol, and n‐hexanol from dilute aqueous solutions using scCO2, measuring the initial extraction rates and extraction efficiencies, where the extraction efficiency was defined as the grams of alcohol recovered per gram of scCO2. In all cases, the extraction kinetics were well described by a simple first‐order disappearance model and the extraction rates were much greater than the published butanol bioproduction rates. Quantitatively, the initial extraction rates and efficiencies, respectively, for both n‐hexanol and n‐pentanol were 1.6±0.2 and 1.3±0.1 times greater than that for n‐butanol. These results were analyzed for semi‐continuous alcohol recovery and compared with previous literature on butanol gas stripping to evaluate the competitiveness of the scCO2 separation strategy.
To Go or Not to Go: A Proof of Concept Study Testing Food‐Specific Inhibition Training for Women with Eating and Weight Disorders
Authors: Turton Robert , Nazar Bruno P. , Burgess Emilee E. , Lawrence Natalia S. , Cardi Valentina , Treasure Janet , Hirsch Colette R. 
Published: November 2017

AbstractInefficient food‐specific inhibitory control is a potential mechanism that underlies binge eating in bulimia nervosa and binge eating disorder. Go/no‐go training tools have been developed to increase inhibitory control over eating impulses. Using a within‐subjects design, this study examined whether one session of food‐specific go/no‐go training,versusgeneral inhibitory control training, modifies eating behaviour. The primary outcome measure was food consumption on a taste test following each training session. Women with bulimia nervosa and binge eating disorder had small non‐significant reductions in high‐calorie food consumption on the taste test following the food‐specific compared with the general training. There were no effects on eating disorder symptomatic behaviour (i.e. binge eating/purging) in the 24 h post‐training. The training task was found to be acceptable by the clinical groups. More research is needed with larger sample sizes to determine the effectiveness of this training approach for clinical populations. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns
Authors: Jackson Joshua G. , Robinson Michael B. 
Published: November 2017

AbstractAstrocytes are the major glial cell in the central nervous system. These polarized cells possess numerous processes that ensheath the vasculature and contact synapses. Astrocytes play important roles in synaptic signaling, neurotransmitter synthesis and recycling, control of nutrient uptake, and control of local blood flow. Many of these processes depend on local metabolism and/or energy utilization. While astrocytes respond to increases in neuronal activity and metabolic demand by upregulating glycolysis and glycogenolysis, astrocytes also possess significant capacity for oxidative (mitochondrial) metabolism. Mitochondria mediate energy supply and metabolism, cellular survival, ionic homeostasis, and proliferation. These organelles are dynamic structures undergoing extensive fission and fusion, directed movement along cytoskeletal tracts, and degradation. While many of the mechanisms underlying the dynamics of these organelles and their physiologic roles have been characterized in neurons and other cells, the roles that mitochondrial dynamics play in glial physiology is less well understood. Recent work from several laboratories has demonstrated that mitochondria are present within the fine processes of astrocytes, that their movement is regulated, and that they contribute to local Ca2+ signaling within the astrocyte. They likely play a role in local ATP production and metabolism, particularly that of glutamate. Here we will review these and other findings describing the mechanism by which mitochondrial dynamics are regulated in astrocytes, how mitochondrial dynamics might influence astrocyte and brain metabolism, and draw parallels to mitochondrial dynamics in neurons. Additionally, we present new analyses of the size, distribution, and dynamics of mitochondria in astrocytes performed using in vivo using 2‐photon microscopy.
Preliminary study of a communication intervention for family caregivers and spouses with dementia
Authors: Williams Christine L. , Newman David , Hammar Lena Marmstål 
Published: November 2017

ObjectiveThis study was to designed to examine the feasibility and preliminary outcomes of CARE: Caring About Relationships and Emotions, a 10‐week, home‐based, intervention to support married couples affected by dementia.MethodsFifteen older couples participated in a single group repeated measures feasibility study. Weekly, video‐recorded conversations over 10 weeks were used to rate communication using the Verbal/Nonverbal Interaction Scale for caregivers and care receivers.ResultsAccounting for mental status of care recipients, the ratio of social to unsocial communication showed a significant improvement across sessions‐an average of 4.46 points per session [β = 4.46, t(10) = 1.96, p = .039]. Spouse caregiver (CG) communication showed a significant decrease in the number of disabling communications with approximately .65 decreased comments per session [β = 0.654, t(11) = −2.61, p = .024].ConclusionsAt home dyadic, relationship‐focused psychoeducational intervention to improve communication in spouses affected by dementia has the potential to improve communication outcomes. Creative ways of working with couples are needed to help them sustain their relationships and maintain their health.
A pilot study investigating the feasibility of symptom assessment manager (SAM), a Web‐based real‐time tool for monitoring challenging behaviors
Authors: Loi Samantha M. , Wanasinghage Sangeeth , Goh Anita , Lautenschlager Nicola T. , Darby David G. , Velakoulis Dennis 
Published: November 2017

ObjectiveImproving and minimizing challenging behaviors seen in psychiatric conditions, including behavioral and psychological symptoms of dementia are important in the care of people with these conditions. Yet there is a lack of systematic evaluation of these as a part of routine clinical care. The Neuropsychiatric Inventory is a validated and reliable tool for rating the severity and disruptiveness of challenging behaviors. We report on the evaluation of a Web‐based symptom assessment manager (SAM), designed to address the limitation of previous tools using some of the Neuropsychiatric Inventory functions, to monitor behaviors by staff caring for people with dementia and other psychiatric conditions in inpatient and residential care settings.MethodsThe SAM was piloted in an 8‐bed inpatient neuropsychiatry unit over 5 months. Eleven nurses and 4 clinicians were trained in usage of SAM. Primary outcomes were usage of SAM and perceived usability, utility, and acceptance of SAM. Secondary outcomes were the frequencies of documented behavior. Usage data were analyzed using chi‐square and logistic regression analyses.ResultsThe SAM was used for all admitted patients regardless of diagnosis, with a usage rate of 64% for nurses regularly employed in the unit. Staff provided positive feedback regarding the utility of SAM.ConclusionsThe SAM appeared to offer individualized behavior assessment by providing a quick, structured, and standardized platform for assessing behavior in a real‐world setting. Further research would involve trialing SAM with more staff in alternative settings such as in home or residential care settings.
Increased functional connectivity in the ventral and dorsal streams during retrieval of novel words in professional musicians
Authors: Dittinger Eva , Valizadeh Seyed Abolfazl , Jäncke Lutz , Besson Mireille , Elmer Stefan 
Published: November 2017

AbstractCurrent models of speech and language processing postulate the involvement of two parallel processing streams (the dual stream model): a ventral stream involved in mapping sensory and phonological representations onto lexical and conceptual representations and a dorsal stream contributing to sound‐to‐motor mapping, articulation, and to how verbal information is encoded and manipulated in memory. Based on previous evidence showing that music training has an influence on language processing, cognitive functions, and word learning, we examined EEG‐based intracranial functional connectivity in the ventral and dorsal streams while musicians and nonmusicians learned the meaning of novel words through picture–word associations. In accordance with the dual stream model, word learning was generally associated with increased beta functional connectivity in the ventral stream compared to the dorsal stream. In addition, in the linguistically most demanding “semantic task,” musicians outperformed nonmusicians, and this behavioral advantage was accompanied by increased left‐hemispheric theta connectivity in both streams. Moreover, theta coherence in the left dorsal pathway was positively correlated with the number of years of music training. These results provide evidence for a complex interplay within a network of brain regions involved in semantic processing and verbal memory functions, and suggest that intensive music training can modify its functional architecture leading to advantages in novel word learning.
Photofunctionalization of anodized titanium surfaces using UVA or UVC light and its effects against Streptococcus sanguinis
Authors: Jain Sakshi , Williamson Randall S. , Marquart Mary , Janorkar Amol V. , Griggs Jason A. , Roach Michael D. 
Published: November 2017

AbstractUV light preirradiation of anodized titanium oxide layers has recently been shown to produce a photocatalytic effect that may reduce early bacterial attachment on titanium surfaces. Streptococcus species have been identified as primary early colonizers and contribute to early biofilm formation on dental implant surfaces. Anodized layers with primarily amorphous, primarily anatase, primarily rutile, and mixtures of anatase and rutile phase oxides were preirradiated with UVA or UVC light for 10 min. Nanoscale surface roughness and pre‐ and post‐UV‐irradiated wettability were measured for each anodization group. Sample groups were subjected to streptococcus sanguinis for a period of 24 h. Bacterial attachment and killing efficacy were measured and compared to the corresponding non‐UV control groups. UVA treatments showed trends of at least a 20% reduction in bacterial attachment regardless of the crystallinity, or combination of oxide phases present. Anodized layers consisting of primarily anatase phase on the outermost surface were shown to have a killing efficacy of at least 50% after preirradiation with UVA light. Anodized layers containing disperse mixtures of anatase and rutile phases at the outermost surface showed at least a 50% killing efficacy after pre‐irradiation with either UVA or UVC light. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2284–2294, 2018.