bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplikasi Peminjaman dan Pengembalian Koleksi Berbasis Framework Code Igniter di Perpustakaan Jurusan Teknik Sipil dan Lingkungan Fakultas Teknik UGM
Authors: Wijaya Bagus 
Published: November 2016

A library is an important facility to support the academic activities of students. There are various types of collections that require good management in order that the information retained in the collections can be utilized by the user. The collection in the library can be easily borrowed and returned quickly so as to improve the efficiency and effectiveness of the performance of library staff. The author aimed to facilitate library staff in providing collection circulation services, especially for students majoring in Civil and Environmental Engineering. The application was expected to give fast and accurate process in data as well as report collection.
Pengaruh Ketersediaan Koleksi Buku Fiksi Terhadap Minat Kunjung Siswa di Perpustakaan SMK Muhammadiyah Gamping Yogyakarta
Authors: Hastoro Bayu Widya , Rumani Sri 
Published: November 2016

The purpose of the study is to identify (1) availability of fiction book collection at the library of SMK Muhammadiyah Gamping (2) animo of visits to the library of SMK Muhammadiyah Gamping (3) effects of availability of fiction book collection to animo of visits to the library of SMK Muhammadiyah Gamping (4) the degree of effects of the availability of fiction book collection to animo of visits to the library of SMK Muhammadiyah Gamping. Data were obtained through questionnaire, observation, interview, and documentation. The independent variable is availability of fiction book collection and the dependent variable is animo of visits. Analysis used product moment correlation and simple linear regression. Sampling used accidental technique involving 71 respondents. Data were processed using SPSS 22 for Windows. The result of the study showed there was effect of availability of fiction book collection to animo of visits (tcalculation was 0.644 and ttable 0.227). Thus the hypothesis that there was positive and significat effect of the availability of fiction book collection to animo of visits to the library of SMK Muhammadiyah Gamping was accepted. The degree of effect was obtained through squaring t table with the score 0.415 which indicated that animo of visits was affected by availability of fiction book collection as much as 41.5% and the rest (58.5%) was affected by other factors.
Role of Echocardiography in Diagnosis and Treatment of Patients with Infective Endocarditis
Authors: Srbinovska Kostovska Elizabeta , Tosev Slavco , Andova Valentina , Antova Emilija 
Published: November 2016

Abstract
Infective endocarditis is an endovascular microbial infection of cardiovascular structures, localized on valves, large intrathoracic vessels, ventricular and atrial endocardium and prosthetic materials. IE may present as an acute, subacute and chronic disease. The incidence of IE ranges from one country to another within 3-10 episodes/100.000 persons per years. The classification of IE according to the localization of the infection is: left-sided native valve IE, left-sided prosthetic valve IE (PVE), right-sided IE and device-related IE.
Echocardiography plays a key role in each of the steps of assessment of IE: the diagnosis, risk stratification and follow-up of patients with infective endocarditis. The major echocardiographic criteria for IE are discovering vegetations, abscess, new valvular regurgitation and prosthesis dehiscence. According to the recent ESC recommendation for diagnosis and assessment of patients with IE, in all patients with clinical suspicion of IE, transthoracic echocardiography (TTE) is the first step of assessment. If we speak about patients with prosthetic endocarditis, then transoesophageal echocardiography (TEE) is recommended in case of poor quality of TTE and in majority of patients with positive TTE. If TTE examination is negative with low suspicion of IE, further follow-up has to be stopped. If TTE is negative but there is a high suspicion of IE, TEE has to be repeated in 7-10 days. Anatomical features on IE echocardiography have specific characteristics: vegetation, destructive valve lesion (perforation, prolapse of the valve) and abscess formation (more frequent in Ao valve and in prosthetic valve), which can be complicated with pseudoaneurysm and fistulization). Other cardiac imaging modalities (multislice computed tomogramphy (CT), magnetic resonance, 18F-fluorodesoxyglucose PET-CT, and single photon emission computed tomography (SPECT) /CT sometimes can be used in discovering complications in IE.
Conclusion: Echocardiography is useful in diagnosis of endocarditis, assessment of the severity of the disease, prediction of short-term and long-term prognosis, prediction of embolic risk, management of its complications, as well as deciding whether to operate or not and in choosing optimal time for surgery and follow-up.
A Review: Lantibiotics, a Promising Antimicrobial Agent
Authors: Basi-Chipalu Shradha 
Published: November 2016

Rise in multi drug resistant bacteria has been a public health problem. This has necessitated for the exploration of novel antimicrobials. Bacteriocins, probiotic bacteria, and bacteriophages are considered as alternatives to antibiotics. To this context, lantibiotics could be the future candidate for antimicrobial agent.Lantibiotics are synthesized ribosomally and after posttranslational modification active peptide is produced.Lantibiotics are lanthionine and methyllanthionine containing peptides exhibiting activity against multi drug resistant pathogens. Besides its application as alternatives to old antibiotics, they can be used as food preservatives, additives, probiotics, and prophylactics.Journal of Institute of Science and TechnologyVolume 21, Issue 1, August 2016, Page: 119-128
Scale invariance of shallow seismicity and the prognostic signatures of earthquakes
Authors: Stakhovsky I R 
Published: November 2016

Abstract

The results of seismic investigations based on methods of the theory of nonequilibrium processes and self-similarity theory have shown that a shallow earthquake can be treated as a critical transition that occurs during the evolution of a non-equilibrium seismogenic system and is preceded by phenomena such as the scale invariance of spatiotemporal seismic structures. The implication is that seismicity can be interpreted as a purely multifractal process. Modeling the focal domain as a fractal cluster of microcracks allows formulating the prognostic signatures of earthquakes actually observed in seismic data. Seismic scaling permits monitoring the state of a seismogenic system as it approaches instability.
La géographie, un outil diplomatique ? Rivalités impériales et collaborations internationales dans le nord de la péninsule indochinoise (fin xix e – début xx e  siècles)
Authors: de Rugy Marie 
Published: November 2016

Si l’antagonisme franco-anglais dans la péninsule indochinoise est bien connu, les coopérations internationales et particulièrement les collaborations entre les différents services géographiques n’ont guère été étudiées. Elles constituent l’objet de cet article, dont l’enjeu est de montrer que la cartographie n’est pas seulement un ferment de discorde mais peut être un véritable instrument diplomatique. Les nécessités scientifiques de la géodésie produisent des échanges bilatéraux, tandis que la présence d’un Britannique à la tête du Service géographique siamois interpelle sur la réalité de la mainmise anglaise au Siam. Les échanges institutionnels entre les services géographiques pourraient enfin constituer les prémices d’une diplomatie culturelle. La géographie ne sert donc pas qu’à faire la guerre.
Transporter de la main-d’œuvre chinoise à Panama : enjeux économiques et représentations d’un jeune ingénieur suisse à la fin du xix e  siècle
Authors: Tissot Laurent 
Published: November 2016

À côté de ressortissants d’autres régions asiatiques et des Antilles, le recrutement de main-d’œuvre chinoise a connu au xix	e  siècle un essor considérable. À l’origine des nombreuses Chinatowns, il intensifie un mouvement d’implantation de la Chine en Occident, notamment en Amérique. L’engagement en 1886 d’un jeune ingénieur suisse par une société chargée de construire le canal de Panama présente l’intérêt de lier les enjeux économiques attachés à sa mission aux représentations suscitées par sa vision extérieure de la Chine et la connaissance qu’il en acquiert sur le terrain. Sur la base des correspondances entretenues avec ses parents par cet ingénieur, cet article vise à mieux comprendre comment il voit la Chine dans ce qu’elle a produit à l’extérieur et dans la façon dont l’Occident l’intègre dans son imaginaire.
L’idéologie dans les relations sino-européennes. L’ambassadeur Guo aux pays de Yi (1877-1879)
Authors: Chu Xiaoquan 
Published: November 2016

L’héritage culturel dévoile le ressort idéologique des comportements peu rationnels dans les relations entre la Chine et l’Occident. De ce point de vue, le cas de Songtao Guo n’est pas sans pertinence aujourd’hui. Les tribulations du premier ambassadeur chinois en Occident au xix	e siècle s’expliquent par le profond enracinement de la distinction entre Xia et Yi, désignations de deux identités ethnoculturelles, présentes dans la mentalité chinoise depuis deux millénaires. La crispation de la classe des fonctionnaires-lettrés de l’époque vis-à-vis de l’ouverture forcée de la Chine impériale a été provoquée non par la prise en compte des intérêts réels de la Chine mais par une perception des relations internationales faussée par cette vision idéologique. On peut encore se demander si, de nos jours, les relations entre la Chine et l’Occident restent influencées par ce type de considérations.
Chercher, construire et combattre l’ennemi. Pour une nouvelle historicité de la guerre contre la terreur
Authors: Le Chaffotec Boris 
Published: November 2016

La littérature scientifique semble s’accorder sur le rôle déclencheur des attentats du 11 septembre 2001 dans la guerre menée par les États-Unis contre la terreur. Les discours de George W. Bush des 12 et 20 septembre ainsi que l’autorisation législative de l’usage de la force armée à l’encontre des responsables des attentats de New York, de Washington et de Pennsylvanie le 18 septembre vont dans ce sens. Cette lecture offre une temporalité binaire consacrant la rupture historique que constitueraient ces évènements. Pourtant, ni l’identification de la terreur, ni la militarisation de la lutte antiterroriste ne furent le fait de l’administration républicaine. Aussi, nous proposons-nous d’établir une nouvelle historicité de la guerre contre la terreur en adoptant une approche à plus long terme. À travers les archives des administrations de George Bush, Bill Clinton et George W. Bush ainsi que celles du Congrès, nous la replacerons dans une histoire de la politique étrangère américaine d’après-Guerre froide.
Implementation of E-learning in an Electrical Engineering Study Program - Infrastructure, Experiences, and Lessons Learned
Authors: Feldmann Nina , Kurz Raphael , Böhmer Cornelia , Beck-Meuth Eva Maria 
Published: November 2016

This paper reports on the development of
e-learning material for a blended-learning part-time study program in electrical engineering and information technology. It is focused on the entire process of creation, from the perspective of instructors and higher education professionals supporting the production. In the design of the program, the development of effective study material including e-learning content for the target group was one of the main objectives. Associated with the development of this material, various challenges had to be overcome. In the following, we describe the development and implementation process of the material using results from a survey among lecturers who were contributing e-learning to the program. Different manifestations of e-learning are discussed, and the whole process of production is reviewed. In the current efforts for digitizing higher education in Europe, the findings may be relevant for universities’ e-learning strategies.
<b>Uma análise espacial do emprego no setor de confecções do Rio Grande do Norte (2004 e 2014)
Authors: Lima Elaine Carvalho de , Alves Janaina Da Silva 
Published: November 2016

Esse trabalho busca verificará o impacto da clusterização horizontal no crescimento do emprego das micros, pequenas e médias empresas (MPME´S) do setor de confecções no Rio Grande do Norte, nos anos de 2004 e 2014. Nesse contexto, consideram-se os argumentos microfundamentados por Fujita e Thisse (2002) que apontam as economias externas como explicação da clusterização. Em termos metodológicos, a pesquisa se desenvolveu por meio da análise do instrumental da Análise Exploratória de Dados Espaciais (AEDE), com destaque para as estatísticas de autocorrelação espacial I de Moran e Moran Local e utilizou-se do modelo proposto por Fingleton, Igliori e Moore (2005) com o procedimento baseado no modelo de Mínimo Quadrado Ordinário de Dois Estágios (MQO2E). Os resultados mostraram que, para o setor de confecções do Rio Grande do Norte, para o período 2004 a 2014, a clusterização horizontal gerou externalidades positivas sobre o crescimento do emprego nas MPME’s desse setor, porém estas são contrabalanceadas com impactos negativos, também conhecidos como efeito congestão.
Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages
Authors: Deng Wenhai , Yang Jialong , Lin Xingguang , Shin Jinwook , Gao Jimin , Zhong Xiao-Ping 
Published: November 2016

Abstract
Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ self-renewal remain poorly understood. We found that myeloid-specific deletion of Raptor, an essential component of the mammalian/mechanistic target of rapamycin complex (mTORC)1, resulted in a marked decrease of this population of cells accompanying altered phenotypic features and impaired phagocytosis activity. We demonstrated further that Raptor/mTORC1 deficiency did not affect AMϕ development, but compromised its proliferative activity at cell cycle entry in the steady-state as well as in the context of repopulation in irradiation chimeras. Mechanically, mTORC1 confers AMϕ optimal responsiveness to GM-CSF–induced proliferation. Thus, our results demonstrate an essential role of mTORC1 for AMϕ homeostasis by regulating proliferative renewal.
Generation of a Novel HLA Class I Transgenic Mouse Model Carrying a Knock-in Mutation at the β2-Microglobulin Locus
Authors: Harada Naomoto , Fukaya Satoshi , Wada Hiroshi , Goto Risa , Osada Toshihiro , Gomori Akira , Ikizawa Koichi , Sakuragi Motomu , Oda Nobuyuki 
Published: November 2016

Abstract
We generated a series of monochain HLA class I knock-in (KI) mouse strains, in which a chimeric HLA class I molecule (α1/α2 domain of HLA-A*0201, HLA-A*0301, HLA-A*2402, or HLA-A*3101 and α3 domain of H-2Db) was covalently linked with 15 aa to human β2-microglobulin (β2m) and introduced into the endogenous mouse β2m locus. In homozygous KI mice, mouse β2m gene disruption resulted in loss of the endogenous H-2 class I molecules and reduction in the peripheral CD8+ T cell population that was partially restored by monochain HLA class I expression. A gene dosage-dependent expression of HLA, similar to that in human PBMCs, was detected in heterozygous and homozygous HLA KI mice. Upon vaccination with various virus epitopes, HLA-restricted, epitope-specific CTLs were induced in HLA KI mice, similar to the response in the commonly used HLA transgenic mice. Importantly, the CTL responses induced in heterozygous KI mice were similar to those in homozygous KI mice. These results suggest that coexpression of H-2 class I does not affect HLA-restricted CTL responses in HLA KI mice, which differs from the situation reported for monochain HLA Tg × β2m−/− mice. Furthermore, we generated double KI mice harboring two different HLA (HLA-A*2402 and HLA-A*0301) KI alleles, which showed a CTL response against both HLA-A24 and HLA-A3 epitopes when immunized with a mixture of both peptides. These results indicated that this HLA class I KI mouse model provides powerful research tools not only for the study of HLA class I–restricted CTL responses, but also for preclinical vaccine evaluation.
Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4+ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine
Authors: Ko Eun-Ju , Lee Young-Tae , Kim Ki-Hye , Lee Youri , Jung Yu-Jin , Kim Min-Chul , Lee Yu-Na , Kang Taeuk , Kang Sang-Moo 
Published: November 2016

Abstract
Vaccine adjuvant effects in the CD4-deficient condition largely remain unknown. We investigated the roles of combined monophosphoryl lipid A (MPL) and aluminum hydroxide (Alum) adjuvant (MPL+Alum) in inducing immunity after immunization of CD4 knockout (CD4KO) and wild-type (WT) mice with T-dependent influenza vaccine. MPL+Alum adjuvant mediated IgG isotype-switched Abs, IgG-secreting cell responses, and protection in CD4KO mice, which were comparable to those in WT mice. In contrast, Alum adjuvant effects were dependent on CD4+ T cells. MPL+Alum adjuvant was effective in recruiting monocytes and neutrophils as well as in protecting macrophages from Alum-mediated cell loss at the injection site in CD4KO mice. MPL+Alum appeared to attenuate MPL-induced inflammatory responses in WT mice, likely improving the safety. Additional studies in CD4-depleted WT mice and MHC class II KO mice suggest that MHC class II+ APCs contribute to providing alternative B cell help in the CD4-deficient condition in the context of MPL+Alum–adjuvanted vaccination.
IL-35 Suppresses Lipopolysaccharide-Induced Airway Eosinophilia in EBI3-Deficient Mice
Authors: Kanai Kyosuke , Park Ah-Mee , Yoshida Hiroki , Tsunoda Ikuo , Yoshie Osamu 
Published: November 2016

Abstract
EBI3 functions as the subunit of immune-regulatory cytokines, such as IL-27 and IL-35, by pairing with p28 and p35, respectively. We treated wild-type and EBI3-deficient mice with intratracheal administration of LPS and obtained bronchoalveolar lavage fluid (BALF) 24 h later. Although neutrophils were the predominant cells in BALF from both groups of mice, eosinophils were highly enriched and there was increased production of eosinophil-attracting chemokines CCL11 and CCL24 in BALF of EBI3-deficient mice. The bronchial epithelial cells and alveolar macrophages were the major producers of CCL11 and CCL24. Because no such increases in eosinophils were seen in BALF of p28/IL-27–deficient mice or WSX-1/IL-27Rα subunit-deficient mice upon intratracheal stimulation with LPS, we considered that the lack of IL-35 was responsible for the enhanced airway eosinophilia in EBI3-deficient mice. In vitro, IL-35 potently suppressed production of CCL11 and CCL24 by human lung epithelial cell lines treated with TNF-α and IL-1β. IL-35 also suppressed phosphorylation of STAT1 and STAT3 and induced suppressor of cytokine signaling 3. In vivo, rIL-35 dramatically reduced LPS-induced airway eosinophilia in EBI3-deficient mice, with concomitant reduction of CCL11 and CCL24, whereas neutralization of IL-35 significantly increased airway eosinophils in LPS-treated wild-type mice. Collectively, our results suggest that IL-35 negatively regulates airway eosinophilia, at least in part by reducing the production of CCL11 and CCL24.
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
Authors: Douthwaite Julie , Moisan Jacques , Privezentzev Cyril , Soskic Blagoje , Sabbah Shereen , Cohen Suzanne , Collinson Andie , England Elizabeth , Huntington Catherine , Kemp Ben , Zhuang Li , Hudak Suzanne , Rees D. Gareth , Goldberg Debbie , Barton Chris , Chang Linda , Vainshtein Inna , Liang Meina , Iciek Laurie , Ambery Philip , Peakman Mark , Vaughan Tristan J. , Tree Tim I. M. , Sansom David M. , Bowen Michael A. , Minter Ralph R. , Jermutus Lutz 
Published: November 2016

Abstract
Affinity- and stability-engineered variants of CTLA4-Ig fusion molecules with enhanced pharmacokinetic profiles could yield improved therapies with the potential of higher efficacy and greater convenience to patients. In this study, to our knowledge, we have, for the first time, used in vitro evolution to simultaneously optimize CTLA4 affinity and stability. We selected for improved binding to both ligands, CD80 and CD86, and screened as dimeric Fc fusions directly in functional assays to identify variants with stronger suppression of in vitro T cell activation. The majority of CTLA4 molecules showing the largest potency gains in primary in vitro and ex vivo human cell assays, using PBMCs from type 1 diabetes patients, had significant improvements in CD80, but only modest gains in CD86 binding. We furthermore observed different potency rankings between our lead molecule MEDI5265, abatacept, and belatacept, depending on which type of APC was used, with MEDI5265 consistently being the most potent. We then created fusions of both stability- and potency-optimized CTLA4 moieties with human Fc variants conferring extended plasma t1/2. In a cynomolgus model of T cell–dependent Ab response, the CTLA4-Ig variant MEDI5265 could be formulated at &gt;100 mg/ml for s.c. administration and showed superior efficacy and significantly prolonged serum t1/2. The combination of higher stability and potency with prolonged pharmacokinetics could be compatible with very infrequent, s.c. dosing while maintaining a similar level of immune suppression to more frequently and i.v. administered licensed therapies.
Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells
Authors: Xue Di , Kaufman Gabriel N. , Dembele Marieme , Beland Marianne , Massoud Amir H. , Mindt Barbara C. , Fiter Ryan , Fixman Elizabeth D. , Martin James G. , Friedel Roland H. , Divangahi Maziar , Fritz Jörg H. , Mazer Bruce D. 
Published: November 2016

Abstract
The regulatory properties of B cells have been studied in autoimmune diseases; however, their role in allergic diseases is poorly understood. We demonstrate that Semaphorin 4C (Sema4C), an axonal guidance molecule, plays a crucial role in B cell regulatory function. Mice deficient in Sema4C exhibited increased airway inflammation after allergen exposure, with massive eosinophilic lung infiltrates and increased Th2 cytokines. This phenotype was reproduced by mixed bone marrow chimeric mice with Sema4C deficient only in B cells, indicating that B lymphocytes were the key cells affected by the absence of Sema4C expression in allergic inflammation. We determined that Sema4C-deficient CD19+CD138+ cells exhibited decreased IL-10 and increased IL-4 expression in vivo and in vitro. Adoptive transfer of Sema4c−/− CD19+CD138+ cells induced marked pulmonary inflammation, eosinophilia, and increased bronchoalveolar lavage fluid IL-4 and IL-5, whereas adoptive transfer of wild-type CD19+CD138+IL-10+ cells dramatically decreased allergic airway inflammation in wild-type and Sema4c−/− mice. This study identifies a novel pathway by which Th2-mediated immune responses are regulated. It highlights the importance of plasma cells as regulatory cells in allergic inflammation and suggests that CD138+ B cells contribute to cytokine balance and are important for maintenance of immune homeostasis in allergic airways disease. Furthermore, we demonstrate that Sema4C is critical for optimal regulatory cytokine production in CD138+ B cells.