bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of corporate social responsibility on sustainable agriculture and livelihood of farmers
Authors: Misra Shuchi Benara , Kumari Sneha , Miglani Varun 
Published: September 2024

AbstractRural areas have low levels of advancement and access to resources compared to urban regions, and elevating these regions is fundamental for accomplishing balanced and sustainable development. Rural uplifting typically includes a range of interventions, and by drawing in local stakeholders, rural uplifting projects can make sustainable arrangements that are custom‐made for each community's unique difficulties and opportunities. Corporate social responsibility (CSR) can contribute to and aid the government's efforts in rural development. CybageAsha's (CSR department of Cybage Software) flagship programs seek to improve rural communities through sustainable solutions. These encompass income‐generating interventions using contemporary agricultural methods as well as infrastructure development. This article analyses the impact of agricultural interventions on the farmers' livelihoods carried out by CybageAsha in 19 villages across the Pune district (India) by using the t‐test and difference‐in‐difference approach. Findings reveal that the shift from traditional farming methods to adopting new farming methods among beneficiaries has added value in improving the beneficiaries' yields, incomes, skills, and livelihood. CybageAsha's interventions positively impacted the beneficiaries, contributing to agricultural development, livelihood improvement, income generation, and a decline in migration. However, there is a need for continuous support and improvement to sustain the benefits for farmers. The article provides a new understanding for researchers and practitioners about the CSR approaches towards agricultural development. Addressing the challenges and concerns identified in the data analysis will further enhance the effectiveness of rural uplifting initiatives.
The formation of a sustainable organizational identity: Insights from Brazilian coffee producers
Authors: Kyrdoda Yuliia , Balzano Marco , Vianelli Donata 
Published: September 2024

AbstractOrganizations craft their identities to define their character and effectively communicate their values to stakeholders. In the contemporary quest for sustainability, building an identity that genuinely reflects their awareness and attention to these issues is increasingly salient. Over the years, research on organizational identity exhibited constant growth, witnessing the power of organizational identities exerted over organizational behavior. Prior research has emphasized the importance of organizational identity for an array of positive organizational outcomes. Still, much less is known about the levers behind the identity formation process. Against this backdrop, the present study explores the pathways to the formation of a sustainable organizational identity. By drawing on organizational identity and sensemaking literature, we build up a narrative inquiry, analyzing the experiences and perspectives of executives from 25 Brazilian coffee producers through in‐depth interviews. The findings underline that the process of formation involves three phases, namely, orienting toward sustainability, acting sustainably, and forging a sustainable identity, which are also shaped by contextual factors. We emphasize the key role of leadership in building a sustainable identity, as their motivations and sustainability‐oriented commitments could serve as catalysts for triggering organizational change.
The longitudinal reciprocal relationship between depressive symptoms and life satisfaction among middle‐aged women
Authors: Wang Juanjuan , Hoe Maanse 
Published: September 2024

AbstractSeveral cross‐sectional studies have confirmed the negative correlation between depressive symptoms and life satisfaction; however, there exists limited research on this longitudinal relationship. This study employed the random‐intercept cross‐lagged panel model (RI‐CLPM) to examine the longitudinal reciprocal relationship between depressive symptoms and life satisfaction. For this purpose, a nationally representative sample of middle‐aged women (N = 2,054 at baseline, aged 40–60 years) from the Korean Welfare Panel Data (KoWePS) was analysed. The results of the RI‐CLPM indicate that at the within‐person level, an individual's life satisfaction levels negatively predicted depressive symptoms, and vice versa. This finding indicates that interventions to reduce depressive symptoms may help improve life satisfaction. Conversely, interventions to increase life satisfaction may help to reduce or prevent depressive symptoms. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Naturally Occurring Polyhydroxylated Spirostanol Saponins, A Review of the Classification, Sources, Biosynthesis, Biological Activities, and Toxicity
Authors: Wang Yue‐Hu 
Published: September 2024

AbstractPolyhydroxylated spirostanol saponins, characterized by three or more hydroxy substitutions in the aglycone, have various interesting biological activities. In the present study, “steroids”, “saponins”, “polyhydroxylated”, “spirostanol saponins”, and “steroidal saponins” were used as search terms to screen the literature. Cited references were collected between 1950 and 2023 from the Web of Science, SciFinder, and China National Knowledge Internet (CNKI). A total of 407 polyhydroxylated spirostanol saponins were included in this review. These saponins were classified into three types, α, β, and γ. Polyhydroxylated spirostanol saponins have potential benefits, primarily anti‐inflammatory, antimicrobial, cytotoxic, and cAMP phosphodiesterase inhibitory activities. These compounds were found in 11 plant families and 36 genera. The top three families containing the most saponins were Asparagaceae, Melanthiaceae, and Amaryllidaceae, and the top five genera were Trillium, Helleborus, Allium, Dracaena, and Paris. The top five plants were Trillium tschonoskii Maxim., Ypsilandra thibetica Franch., Paris polyphylla var. yunnanensis (Franch.)Hand.‐Mazz., Helleborus thibetanus Franch., and Helleborus foetidus L. On the basis of their diverse biological activities, these saponins and related plant resources are worthy of further development and utilization.
New Sulfurated Butyrolactones from the Fungus Penicillium janthinellum
Authors: Yang Lu‐Jia , Han Zhuang , Gu Yu‐Cheng , Shao Chang‐Lun , Wang Chang‐Yun 
Published: September 2024

AbstractDeep‐sea derived fungi are considered as significant resources to discovery structurally diverse and biologically active natural compounds. In this study, four new sulfurated butyrolactones, penijanthiones A–D (1–4), together with four known analogues (5–8), were isolated from a Mariana Trench‐derived fungus Penicillium janthinellum SH0301. Compounds 1–4 were the undescribed examples for natural butyrolactones coupling with a mercaptolactate moiety. Their structures including the absolute configurations of these new compounds were elucidated by comprehensive spectroscopic data, and calculated electronic circular dichroism (ECD). The plausible biosynthetic pathway of sulfur‐incorporation of 1–4 was proposed. All of these isolated compounds were evaluated their cytotoxic, antimicrobial and antiviral activities.
Seasonal Study Chemical Profiles and Bioactivities of Hedychium coronarium J. Koenig Essential Oils: Nematicidal, Insecticidal, Phytotoxic, Antifungal Potentials, and Molecular Docking Insights
Authors: Arya Sushila , Kumar Ravendra , Karakoti Himani , Kumar Mahawer Sonu , Prakash Om , Kumar Satya , Latwal Mamta , Panday Ganesh , Santana de Oliveira Mozaniel 
Published: September 2024

AbstractHedychium coronarium plant has attracted considerable attention from researchers due to its diverse phytochemical composition and potential therapeutic applications. The objective of this study was to evaluate the phytochemical profile and biological attributes of H. coronarium essential oils collected during different seasons in the Kumaun region of Uttarakhand. The essential oils were extracted from the rhizomes using hydrodistillation with a Clevenger‐type apparatus yielding between 0.07 % to 0.38 % (w/w). The major compounds identified by GC‐MS analysis exhibited seasonal variations and included 1,8‐cineole (26.6–38.5 %), coronarin E (11.9–18.8 %), α‐pinene (5.00–14.9 %), α‐terpineol (4.2–9.3 %), (E)‐β‐caryophyllene (1.2–9.7 %), and linalool (0.4–2.9 %). To illustrate the variations in oil composition, visualization techniques such as heat map and PCA were employed. The essential oils demonstrated potential biological activity in all tests conducted. The molecular modeling study indicated that the potential mechanism may be associated with acetylcholinesterase. Consequently, this study contributes to the development of novel natural pesticides.
Role of low‐density cholesterol and Interleukin‐17 interaction in breast cancer pathogenesis and treatment
Authors: Liu Qingqing , Yang Rongyuan , Wang Dawei , Liu Qing 
Published: September 2024

AbstractBreast cancer (BC) has become the most prevalent cancer worldwide, and further research is being conducted to deepen our understanding of its pathogenesis and treatment. Lipid metabolism disorder is a significant alteration in cancer cells, and the investigation into the role of Interleukin‐17 (IL‐17) in malignant tumors has emerged as a research focus in recent years. Thus, exploring changes in lipid metabolism and inflammatory factors in BC cells is crucial in identifying potential therapeutic targets. This article summarizes the progress made in the research on the main low‐density cholesterol (LDL) transporter and IL‐17 in lipid metabolism, and their potential involvement in the development of BC. The article aims to establish a theoretical foundation for the development of BC‐related therapies.
Potential of Innovative Concepts STEM Education for Industry 4.0: CrossLab an Example
Authors: Aubel Ines , Zug Sebastian , Bertau Martin 
Published: September 2024

AbstractThe integration of practical, laboratory‐based training in STEM education is of paramount importance. However, traditional methods may prove inadequate in addressing the evolving demands of Industry 4.0. The CrossLab project represents a transformative approach, whereby a modular, interdisciplinary, and cross‐institutional digital laboratory environment is created. This initiative enhances the flexibility, scalability, and collaborative potential of laboratory experiences, thereby equipping students with essential skills in digital literacy, data analysis, and interdisciplinary collaboration. The CrossLab framework represents a novel approach that effectively integrates traditional and digital methods, thereby preparing students for the complexities of Industry 4.0.
The Role of Protein Disulfide Isomerase Inhibitors in Cancer Therapy
Authors: Nie Qiuying , Yang Junwei , Zhou Xiedong , Li Na , Zhang Junmin 
Published: September 2024

AbstractProtein disulfide isomerase (PDI) is a member of the mercaptan isomerase family, primarily located in the endoplasmic reticulum (ER). At least 21 PDI family members have been identified. PDI plays a key role in protein folding, correcting misfolded proteins, and catalyzing disulfide bond formation, rearrangement, and breaking. It also acts as a molecular chaperone. Dysregulation of PDI activity is thus linked to diseases such as cancer, infections, immune disorders, thrombosis, neurodegenerative diseases, and metabolic disorders. In particular, elevated intracellular PDI levels can enhance cancer cell proliferation, metastasis, and invasion, making it a potential cancer marker. Cancer cells require extensive protein synthesis, with disulfide bond formation by PDI being a critical producer. Thus, cancer cells have higher PDI levels than normal cells. Targeting PDI can induce ER stress and activate the Unfolded Protein Response (UPR) pathway, leading to cancer cell apoptosis. This review discusses the structure and function of PDI, PDI inhibitors in cancer therapy, and the limitations of current inhibitors, proposing especially future directions for developing new PDI inhibitors.
Kinetics and Dynamics of Cyclopentanone Thermal Decomposition in Gas Phase
Authors: Priya Himani , Halder Ripan , Paranjothy Manikandan 
Published: September 2024

AbstractCyclopentanone is a potential bio‐fuel which can be produced from bio‐mass. Its gas phase dissociation chemistry has attracted several experimental and theoretical investigations. In the photochemical and thermal decomposition studies of cyclopentanone, ethylene and carbon monoxide were found to be dominant reaction products along with several other compounds in smaller quantities. For the formation of ethylene and carbon monoxide, a concerted mechanism has been proposed as the primary reaction pathway. In addition, a step‐wise mechanism involving ring‐opened radical intermediate has also been considered. The present work reports gas phase thermal decomposition of cyclopentanone at high temperatures investigated using electronic structure theory methods, Rice‐Ramsperger‐Kassel‐Marcus (RRKM) rate constant calculations, and Born‐Oppenheimer direct classical trajectory simulations. The trajectory calculations were performed on density functional PBE96/6‐31+G* potential energy surface using initial conditions selected from fixed energy normal mode distributions. Simulations showed that ethylene and carbon monoxide formed primarily via the concerted mechanism confirming the earlier predictions. In addition, step‐wise pathways were also observed for the same products in lower fraction of trajectories. Furthermore, several other reaction products in smaller quantities and new mechanistic pathways were observed. The computed RRKM rate constants and simulation data are in agreement with experimental results and detailed atomic level dissociation mechanisms presented.
Towards Portable Kits for On‐Site Colorimetric Detection of Aqueous Hydrazine Using Piperidine‐Thiophene‐Barbituric Acid Push‐Pull Probe
Authors: Fernandes Rikitha S , Paul Suvendu , Klikar Milan , Bureš Filip , Dey Nilanjan 
Published: September 2024

AbstractOwing to the carcinogenicity and environmental risks as well as the wide industrial use of hydrazine, we report herein a colorimetric probe for its ratiometric detection in pure water. The developed probe possesses push‐pull architecture with 2‐(piperidyn‐1‐yl) thiophene as the donor, N,N’‐dibutylbarbituric as the acceptor, and butadiene as the spacer. In contrast to weak solvatochromic behavior in organic solvents, the probe showed distinct optical photophysical properties in water resulting from the formation of nanoscopic aggregates. The probe underwent pronounced spectral changes upon the addition of hydrazine including an 11.5‐fold decrease in absorbance and ~2.4‐fold fluorescence quenching. The mechanistic investigation revealed the rapid formation of hydrazone upon the interaction of the probe with hydrazine via retro‐Knoevenagel reaction as confirmed experimentally and corroborated with DFT calculations. The induced colorimetric and fluorometric changes were utilized in hydrazine sensing with excellent selectivity over other biologically relevant analytes with a detection limit of 0.76 μM in aqueous media. The practical utility of the probe was assessed in real‐life natural water samples, while we have also developed a cost‐effective portable kit for the on‐site hydrazine detection both in the solution and vapor phases.
Exciplex Emission in the POSS Possessing Two Kinds of Luminophores
Authors: Narikiyo Hayato , Kato Taichi , Gon Masayuki , Tanaka Kazuo , Chujo Yoshiki 
Published: September 2024

AbstractHere we report the synthesis and luminescent properties of the modified polyhedral oligomeric silsesquioxane (POSS) that possesses two types of luminophores, cyanobenzene and N,N‐diethylaniline for inducing significant emission not only from each dye but also from molecular interactions on the POSS core. From the optical measurements in the diluted solution, we observed both locally‐excited emission and excimer emission originating from intramolecular interactions assisted by POSS. Moreover, highly‐efficient exciplex emission was observed from the thin film, indicating that the interaction between luminophores easily occurs in the solid state by accumulating two kinds of molecules in the single POSS molecule. Finally, we also found that the modified POSS showed a unique acid responsiveness which can be caused by protonation at two types of amino moieties. In this manuscript, it is shown that POSS is able to play various roles at the same time: recruiting excited molecules to form exciplexes, suppressing concentration quenching in the solid state, and imparting stimulus responsiveness to exciplexes.
Nudging towards sustainability: Exploring the role of behavioral interventions in circular bio‐economy development for the fashion industry
Authors: Falcone Pasquale Marcello , Fiorentino Raffaele 
Published: September 2024

AbstractThe fashion and food industries are major contributors to waste generation, making sustainability management a priority for both practitioners and scholars. This study examines how nudging can promote the development of a circular bioeconomy within the fashion industry, specifically investigating whether nudging techniques can facilitate the market adoption of fashion products made from sustainable textiles derived from food waste. Using a dataset of 2112 participants from four European countries, we employ regression and clustering analyses to identify consumer profiles based on psychological and behavioral characteristics. Our econometric analysis reveals that gender, education, and psychological factors such as environmental responsibility and awareness significantly impact sustainable behaviors. Additionally, a left‐leaning political orientation is positively associated with engagement in sustainable practices and willingness to pay for eco‐friendly products. Clustering analysis identifies distinct consumer profiles: “enthusiastic” individuals demonstrate high commitment to sustainability, while “skeptics” shows low engagement and responsiveness to environmental issues. The study offers key policy implications on the effectiveness of nudging interventions in enhancing the sustainability of the fashion industry.
Lignocellulose Treatment Using a Flow‐Through Variant of OrganoCat Process
Authors: Schoofs Leonie , Weidener Dennis , Leitner Walter , Klose Holger , Grande Philipp M. 
Published: September 2024

AbstractThis study adapts the biphasic OrganoCat system into a flow‐through (FT) reactor, using a heated tubular setup where a mixture of oxalic acid and 2‐methyltetrahydrofuran (2‐MTHF) is pumped through beech wood biomass. This method minimizes solvent‐biomass contact time, facilitating rapid product removal and reducing the risk of secondary reactions. A comparative analysis with traditional batch processes reveals that the FT system, especially under severe conditions, significantly enhances extraction efficiency, yielding higher amounts of lignin and sugars with reduced solid residue. Notably, the FT system shows partial hydrolysis of the cellulose, which increases with temperature while not producing significant amounts of furfural or 5‐HMF, indicating more efficient depolymerization of polysaccharides without substantial sugar degradation. A statistical design of experiments (DOE) using a Box‐Behnken design elucidates the influence of process variables (time, solvent flow rate, temperature) on the yield. Key findings highlight reactor temperature as the dominant factor affecting yields, with process time showing a significant but less pronounced impact. This study demonstrates the potential of the FT OrganoCat system for efficient lignocellulosic biomass fractionation and represents an advancement towards continuous lignocellulose processing, contributing to our knowledge of process optimization for improved biorefinery applications.
Mono‐/Bimetallic Doped and Heterostructure Engineering for Electrochemical Energy Applications
Authors: Chu Dawei , Liang Zhongwang , Cheng Yi , Chai Dong‐Feng , Li Meijia 
Published: September 2024

AbstractDesigning efficient materials is crucial to meeting specific requirements in various electrochemical energy applications. Mono‐/bimetallic doped and heterostructure engineering have attracted considerable research interest due to their unique functionalities and potential for electrochemical energy conversion and storage. However, addressing material imperfections such as low conductivity and poor active sites requires a strategic approach to design. This review explores the latest advancements in materials modified by mono‐/bimetallic doped and heterojunction strategies for electrochemical energy applications. It can be subdivided into three key points: (i) the regulatory mechanisms of metal doping and heterostructure engineering for materials; (ii) the preparation methods of materials with various engineering strategies; and (iii) the synergistic effects of two engineering approaches, further highlighting their applications in supercapacitors, alkaline ion batteries, and electrocatalysis. Finally, the review concludes with perspectives and recommendations for further research to advance these technologies.
A review on daidzein as food supplement: Exploring its phytopharmacological and preclinical status
Authors: Ahmad Sana , Ahsan Farogh , Ansari Javed Akhtar , Mahmood Tarique , Shamim Arshiya , Bano Shahzadi , Tiwari Reshu , Ansari Vaseem Ahamad , Shafiurrahman  , Kesari Mithilesh 
Published: September 2024

AbstractA natural product is a compound or substance originating from a living organism and found in nature. Daidzein belongs to the class of bioflavonoids, which are plant‐derived compounds with various biological activities. Predominantly exists in soybeans and several legumes in either glycoside or aglycone forms. Its primary chemical constituents include metabolites like equol and trihydroxy isoflavone, generated through the influence of intestinal bacteria. Daidzein has exhibited pharmacological impacts on different ailments, including cardiovascular disease, cancer, diabetes, skin disorders, osteoporosis, and neurodegenerative disorders. Daidzein's mechanisms of action involve interactions with estrogen receptors, as well as its antioxidant and anti‐inflammatory properties, along with its ability to regulate apoptosis and the cell cycle. In efforts to enhance its solubility, stability, bioavailability, and targeting, daidzein has been innovatively formulated into novel dosage forms, including nanoparticles, liposomes, microemulsions, and nanosuspensions. As a promising nutraceutical, daidzein presents multiple health benefits and holds potential for various clinical applications. Additional investigation is required to comprehend the molecular mechanisms of this phenomenon and assess its safety. The purpose of this review is to provide a short description of the therapeutic properties, chemical composition, traditional use, toxicology profile, new insights on the dosage form, and future prospects of daidzein.