bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital ulcers associated with scleroderma: A major unmet medical need
Authors: Naik Angha , Stratton Richard J. , Leask Andrew 
Published: September 2024

AbstractScleroderma or systemic sclerosis (SSc)‐associated digital ischaemic complications, such as digital ulcers (SSc‐DUs), appear relatively early during the disease course and are a major burden with substantial deterioration of quality of life. Expert rheumatologist and wound specialists have defined a DU; however, international application of the definition is still disorganised. Appearance of SSc‐DUs is secondary to the onset of Raynaud's phenomenon and as a consequence, recommended first‐line of treatment mainly includes vasodilators; however, many DUs are refractory to this treatment. Despite important practical issues, such as a lack of well‐characterised SSc‐wound healing animal model, significant efforts are needed to mechanistically understand the pathogenesis of SSc‐DUs for developing clinically targetable disease modifying therapies.
On the relation between pseudocharacters and Chenevier's determinants
Authors: Ophir Amit 
Published: September 2024

AbstractConsider a commutative unital ring and a unital ‐algebra . Let be a positive integer. Chenevier proved that when is invertible in , the map associating to a determinant its trace is a bijection between ‐valued ‐dimensional determinants of and ‐valued ‐dimensional pseudocharacters of . In this paper, we show that assuming is invertible in is sufficient. This assumption is already made in the definition of a ‐dimensional pseudocharacter. Our proof involves establishing a product formula for pseudocharacters, which might be of independent interest.
CTRP6‐mediated cardiac protection in heart failure via the AMPK/SIRT1/PGC‐1α signalling pathway
Authors: Fan Tingting , Zhu Ningjun , Li Mengli , Wang Zhen , Lin Xianhe 
Published: September 2024

AbstractHeart failure (HF) remains a significant global health concern with limited effective treatments available. C1q/TNF‐related protein 6 (CTRP6) is a member of the CTRP family analogous to adiponectin and its role in HF pathogenesis remains unclear. Here, we investigated the impact of CTRP6 on HF progression. To mimic heart failure with reduced ejection fraction (HFrEF), we used isoproterenol injection in mice and administered adenovirus vectors expressing CTRP6 (Ad‐CTRP6) via tail vein injection. We assessed cardiac function through echocardiography and histology. CTRP6's effects on hypertrophy, fibrosis, apoptosis, oxidative stress and mitochondrial function were analysed. Downstream pathways (phosphorylated AMP‐activated protein kinase (p‐AMPK), sirtuin 1 (SIRT1) and peroxisome proliferator‐activated receptor γ coactivator 1‐α (PGC‐1α) were studied in heart tissues. In vitro, isoproterenol‐stimulated H9c2 cardiomyocytes were treated with CTRP6 to examine viability, apoptosis, F‐actin and signalling proteins. Compound C was used to assess AMPK involvement. CTRP6 expression was lower in the plasma of HF patients. In an isoproterenol‐induced HFrEF mouse model, adenovirus‐mediated overexpression of CTRP6 ameliorated cardiac dysfunction and reduced cardiomyocyte apoptosis, oxidative stress, inflammation and myocardial injury markers. Mechanistically, CTRP6 activation of the AMPK/SIRT1/PGC‐1α signalling pathway restored mitochondrial homeostasis, evidenced by reduced mitochondrial reactive oxygen species levels, increased ATP content, and enhanced mitochondrial complex I/III activities in cardiac tissues. In vitro studies using isoproterenol‐stimulated H9c2 cardiomyocytes corroborated these findings, demonstrating that CTRP6 upregulation attenuated hypertrophy, apoptosis, oxidative stress and mitochondrial dysfunction. Furthermore, these effects were partially reversed by the AMPK inhibitor Compound C, implicating the involvement of the AMPK pathway in CTRP6‐mediated cardioprotection. CTRP6 alleviates HF progression through the AMPK/SIRT1/PGC‐1α signalling pathway.
Prevalence and associations of parapapillary scleral ridges: the Beijing Eye Study
Authors: Jonas Jost B , Panda-Jonas Songhomitra , Xu Jie , Wei Wenbin , Wang Ya Xing 
Published: September 2024

PurposeTo explore the prevalence and associated factors of parapapillary scleral ridges (PSRs).MethodsOut of the cohort of the population-based Beijing Eye Study (n=3468 participants), the study included all eyes with an axial length of ≥25 mm and a randomised sample of eyes with an axial length of <25 mm. Using optical coherence tomographic (OCT) images and fundus photographs, we examined the presence and height of PSRs, defined as a ridge-like structure located on the OCT scans in the parapapillary region.ResultsThe study cohort consisted of 366 eyes (314 individuals; mean age: 63.7±9.7 years). PSR prevalence increased from 0% in the non-myopic group to 3.8% (95% CI 0.3%, 7.3%) in moderately myopic group and 29.2% (95% CI 15.7%, 42.5%) in the highly myopic group. All PSRs were located in the temporal parapapillary gamma zone and corresponded to an ophthalmoscopically visible demarcation line running almost parallel to the optic disc border. Higher PRS prevalence correlated with longer axial length (OR 2.98; 95% CI 1.99, 4.46; p<0.001), female sex (OR 6.48; 95% CI 1.56, 27.0; p=0.01) and older age (OR 1.09; 95% CI 1.01, 1.18; p=0.02). Axial length had the strongest influence (beta: 0.48), followed by sex (beta: 0.20) and age (beta: 0.14). If age was dropped from the multivariable model, myopic maculopathy prevalence (OR 10.0; 95% CI 1.41,70.9; p=0.02) and stage (OR 3.57; 95% CI 1.21, 10.6; p=0.02) became significantly correlated with higher PSR prevalence.ConclusionsWith a PSR prevalence of >60% in eyes with an axial length of >28 mm, PSRs are a common morphological feature of high myopia, with age and female sex as additional associated factors. PSRs may be due to a biomechanical interplay between the optic nerve and the posterior ocular segment of markedly axially elongated eyes.
Impact of the number of dissected lymph nodes on machine learning-based prediction of postoperative lung cancer recurrence: a single-hospital retrospective cohort study
Authors: Kojima Kensuke , Samejima Hironobu , Okishio Kyoichi , Tokunaga Toshiteru , Yoon Hyungeun , Atagi Shinji 
Published: September 2024

BackgroundThe optimal number of lymph nodes to be dissected during lung cancer surgery to minimise the postoperative recurrence risk remains undetermined. This study aimed to elucidate the impact of the number of dissected lymph nodes on the risk of postoperative recurrence of non-small cell lung cancer (NSCLC) using machine learning algorithms and statistical analyses.MethodsWe retrospectively analysed 650 patients with NSCLC who underwent complete resection. Five machine learning models were trained using clinicopathological variables to predict postoperative recurrence. The relationship between the number of dissected lymph nodes and postoperative recurrence was investigated in the best-performing model using Shapley additive explanations values and partial dependence plots. Multivariable Cox proportional hazard analysis was performed to estimate the HR for postoperative recurrence based on the number of dissected nodes.ResultsThe random forest model demonstrated superior predictive performance (area under the receiver operating characteristic curve: 0.92, accuracy: 0.83, F1 score: 0.64). The partial dependence plot of this model revealed a non-linear dependence of the number of dissected lymph nodes on recurrence prediction within the range of 0–20 nodes, with the weakest dependence at 10 nodes. A linear increase in the dependence was observed for ≥20 dissected nodes. A multivariable analysis revealed a significantly elevated risk of recurrence in the group with ≥20 dissected nodes in comparison to those with <20 nodes (adjusted HR, 1.45; 95% CI 1.003 to 2.087).ConclusionsThe number of dissected lymph nodes was significantly associated with the risk of postoperative recurrence of NSCLC. The risk of recurrence is minimised when approximately 10 nodes are dissected but may increase when >20 nodes are removed. Limiting lymph node dissection to approximately 20 nodes may help to preserve a favourable antitumour immune environment. These findings provide novel insights into the optimisation of lymph node dissection during lung cancer surgery.
Effectiveness of Video‐Based Health Education on Breastfeeding Practices Among Infants Aged 0–6 Months in Dirashe District, South Ethiopia: A Cluster Randomized Controlled Trial
Authors: Boynito Wanzahun Godana , Diongue Ousmane , Temesgen Kidus , Yeshitila Yordanos Gizachew , Tessema Godana Yaya , De Souza Marielle , De Henauw Stefaan , Diouf Adama , Abbeddou Souheila 
Published: September 2024

Background: Exclusive breastfeeding (EBF) of infants during the first 6 months of their life is strongly recommended. Video‐based communication is an innovative method that could promote EBF. The present study is aimed at assessing the effectiveness of video‐based intervention in promoting breastfeeding practices from birth to 6 months postpartum. This was evaluated through maternal reports, as well as EBF of infants at 3 and 5 months of age, using the deuterium oxide dose‐to‐mother (DTM) technique.Methods: In a cluster randomized community trial, 16 communities were assigned to receive a video‐based behavior change communication (Video‐Health) or standard health care messages (Control). Pregnant women in their first trimester (12 ± 2 weeks) were enrolled and followed up, together with their infants, until 6 months postpartum. Data on breastfeeding practices were collected by questionnaire, monthly, in all the participants (n = 508). Human milk intake (HMI) and nonmilk oral intake (NMOI) were measured in a subsample of 60 mother–infant pairs at 3 and 5 months postpartum using DTM. Mixed models and logistic regression were used to examine the difference in continuous and discrete breastmilk practices between the intervention and the control arms, respectively.Results: The majority of mothers initiated breastfeeding early (92.1%), 82.4% reported colostrum feeding, and 17.5% provided prelacteal feeding. No significant differences were found between Video‐Health and Control arms (p > 0.05). The intervention significantly improved reported EBF rates at 4 and 5 months postpartum (p < 0.05). DTM results showed that the proportion of women practicing EBF was 50%–67% less than reported at 3 months for both arms and at 5 months in the intervention arm. The intervention did not significantly affect measured EBF at 3 and 5 months postpartum but did improve HMI at 3 months. Non significant differences in NMOI were observed at 3 months, but at 5 months, there was a significant difference between the study arms.Conclusions: Video‐based behavior change communication did not result in significant improvements in reported breastfeeding practices, except for a higher reported adherence to EBF beyond 3 months. Additionally, the intervention had no effect on EBF as measured by the DTM. Early introduction of non‐breastmilk foods and liquids persisted, despite self‐reported EBF extending up to 6 months postpartum.Trial Registration: ClinicalTrials.gov identifier: NCT04414527
Die Konsensehe von 1215 und ihre Darstellung in der Literatur
Authors: Schneidergruber Dietmar 
Published: September 2024

Abstract
This article establishes a connection between the fairy Mären Das Schneekind and Die Suche nach dem glücklichen Ehepaar. The solution presented in the book of penance for a wife with an illegitimate child comes up against the limits set by the cuckolded husband in the fairy Märe Das Schneekind. It is as it were a critique of the preachers’ approach and also shows the limits of the church in what many consider to be private matters. The other fairy Märe reveals the truth behind the seemingly happy marriage. It shows the consequences of the impossible divorce, but also the obviously wrong concept of honor in society. Both fairy Mären do not show a path to happiness and also demonstrate the unchristian end as a solution to the problem.
The Strengthened Linkage between ENSO and the Eurasian Pattern since the Late 1980s
Authors: Cai Qingyu , Chen Wen , Chen Shangfeng , Ma Tianjiao , An Xiadong , Li Zhibo 
Published: September 2024

Abstract
The Eurasian (EU) teleconnection pattern is an important atmospheric intrinsic mode over the extratropical Northern Hemisphere, and it has strong influence on the weather and climate over Eurasia and remote regions. Investigating factors for the EU variability is crucial and has important implications for regional climate prediction. This study reveals a remarkable influence of El Niño–Southern Oscillation (ENSO) on the EU in early winter and particularly a notable enhancement of this influence since the late 1980s. The results indicate that ENSO can lead to the vertical motion and atmospheric heating anomalies over the tropical Indian Ocean, triggering an atmospheric wave train propagating along the subtropical westerly jet and inducing an EU-like pattern over Eurasia in early winter. The interdecadal enhancement of the ENSO impact on the EU after the late 1980s may be attributable to the warming of the background mean sea surface temperature (SST) in the tropical Indian Ocean. In particular, ENSO can lead to stronger atmospheric heating and circulation anomalies over the tropical Indian Ocean via a strong air–sea interaction due to a warmer background mean SST after the late 1980s. A warmer background mean SST in the tropical Indian Ocean accelerates the subtropical westerly jet due to the thermal-wind balance, which is more favorable for the propagation of the atmospheric wave train forced by the atmospheric heating anomalies in the tropical Indian Ocean. The observed mechanisms for the enhanced impact of ENSO on the EU are also validated by numerical experiments.

Significance Statement
The Eurasian (EU) teleconnection pattern is an important atmospheric internal variability with significant influences on the Eurasian climate. The present study finds a remarkable relationship between the EU and ENSO in early winter, and this connection is significantly enhanced in recent decades. Thus, ENSO may serve as an important precursor signal for predicting the EU. Observational analysis and numerical experiments show that the warmer tropical Indian Ocean (TIO) plays a key role in this enhanced relationship. The warmer TIO may enhance the local air–sea interaction and accelerate the subtropical jet. The ENSO-induced anomalous disturbance over the TIO becomes stronger and can more easily propagate along the subtropical jet, exerting a strong influence on the EU especially after the late 1980s.
Comparison of Biomechanical and Surface Characteristics of Retrieved Orthodontic Mini-screws of Three Commercially Available Brands: An In Vivo Study
Authors: Dalvi Khadija M. , Nene Salil S. , Kalia Ajit J. , Mujawar Alfiya , Khan Faraaz M. , Gautam Rajaganesh 
Published: September 2024

Background Mini-screws are valuable devices in orthodontic treatment as they allow effective anchorage. Relocation of a mini-screw may be required due to anatomical limitations. Objectives To compare the morphology and surface characteristics of three brands of mini-screws before and after use and to check their viability for reinsertion. Methodology Mini-screws of three commercially available brands, Group I: Orlus, Ortholution, Korea, Group II: Absoanchor, Dentos, Korea, and Group III: S.K. surgical, India, were evaluated for the sharpness of their threads and active tip, surface roughness, and surface chemical composition using scanning electron microscope (SEM)–energy dispersive spectroscope (EDS) before and after clinical use. Results The sharpness of threads did not differ before and after use in any of the groups. The mean tip deformation values in Groups II and III post-insertion were significantly higher than pre-insertion. The SEM images obtained post-insertion revealed loss of gloss and surface finish with a dull appearance in all groups, but most evident in Group I. EDS analysis post-retrieval shows an increase in the amount of carbon and oxygen in Groups II and III. Conclusion: Mini-screw reuse within the same patient is possible if proper recycling is done, and pilot drilling is done to overcome the decreased cutting ability of the tip due to deformation.
Physician-Modified Endografts with the TREO Stent Graft System
Authors: Papazoglou Dimitrios D. , Karaolanis Georgios I. , Kotelis Drosos , Makaloski Vladimir 
Published: September 2024

Purpose: Description of physician-modified endograft technique and its advantages using the TREO stent graft system. Technique: After partial back-table deployment of the TREO endograft, fenestrations are created using a scalpel and reinforced with a double snare loop and running suture. The distance between the Z-shaped stents of the TREO main body of almost 20 mm allows for more flexible placement of multiple fenestrations and easier and faster re-sheathing. The technique is illustrated with physician modification of a TREO aortic cuff and bifurcated endograft in three patients with juxtarenal aortic aneurysms or type Ia endoleak after previous endovascular aortic aneurysm repair. Conclusion: Physician modification of the TREO stent graft system can be safely performed, making it an excellent additional option to treat juxtarenal aneurysms. Clinical Impact The TREO stent graft system offers various sizing options including different main body lengths and diameters, thus increasing applicability. Larger distance between the main body’s stents facilitates placement of multiple physician-modified fenestrations. Re-sheathing is easier and faster due to the low number of main body stents which have to be re-sheathed. Therefore, the TREO stent graft system is an excellent platform for the physician-modified technique.
Return-to-Work After Attempted Digit Replantation: A Systematic Review of 31 Studies
Authors: Treger Dylan , Weinerman Jonathan , Cai Nathan , Syros Alina , Minaie Arya , Dodds Seth D. 
Published: September 2024

Background: Traumatic digit amputation is a common injury with life-altering consequences for thousands of patients each year. In this study, we aim to update and expand the reported outcomes of return-to-work (RTW) and functional recovery in patients treated with digit replant after traumatic amputation. Methods: A PRISMA-guided systematic review was performed to identify all published articles related to digit replantation following amputation. We queried the following 4 databases: Scopus, Embase, Web of Science, and PubMed-MEDLINE. A total of 31 studies were included in the analysis of return-to-work data. Results: Of the 31 included studies, 26 studies reported that 1976 digits were successfully replanted, while 27 studies reported that 300 replants failed (86.8% success rate). Among 1087 patients in these studies, 82.9% who underwent replantation returned to work. The mean RTW time in 16 studies was 4.7 months (weighted average). Return-to-work time ranged from 0 to 26 months in 12 studies. Of 352 patients who returned to work in 17 studies, 90.9% resumed their previous occupation, while 29 (8.2%) changed occupations. The RTW for finger-only replantations was significantly lower compared to thumb-only, distal digit-only, and any digit replantations (66.0% vs 82.8%; 66.0% vs 87.6%; 66.0% vs 82.9%). Conclusion: Despite a declining prevalence of digit replantation surgery in recent years, this study illustrates that replantation provides beneficial outcomes for patients with a high return-to-work rate.
Investigating undiagnosed Fabry disease in young adults with ischemic stroke: A multicenter cohort study
Authors: Lin Po-Yu , Lin Tien-Yu , Sung Sheng-Feng , Po Helen L. , Hsu Li-Chi , Tang Sung-Chun , Huang Yen-Chu , Hsieh Cheng-Yang , Hsu Yung-Chu , Wu Ren-Ying , Hsieh Cheng-Chi , Sung Pi-Shan , Chen Chih-Hung 
Published: September 2024

Background: The global prevalence of ischemic stroke in young adults is increasing, leading to a significant social impact. Fabry disease is a recognized cause of ischemic stroke in young patients, and although disease-modifying treatments are available, further evidence is needed to confirm their effectiveness in reducing the incidence of ischemic strokes. Aims: This study aimed to identify undiagnosed Fabry disease in young adult patients with ischemic stroke in a Taiwanese cohort. Methods: This multicenter, prospective cohort study enrolled patients aged 20–55 years who had experienced an ischemic stroke or transient ischemic attack (TIA) within 10 days, from 1 January 2016 to 31 December 2020. Screening for Fabry disease was performed using a dry blood test to measure α-galactosidase activity in male patients and blood globotriaosylsphingosine (lyso-Gb3) levels in female patients. For patients with positive screen results, genetic diagnosis of Fabry disease was pursued through Sanger sequencing of the GLA gene, covering all exons and a segment of intron 4. Results: A total of 977 patients (659 male, 68%) were enrolled from seven hospitals across Taiwan. Four patients (0.4%, all male) had positive screening results, and two patients (0.2%) were genetically diagnosed with Fabry disease. Case 1 had the GLA c.658C>T mutation and experienced ischemic stroke in the bilateral occipital regions. Case 2 had the GLA c.640-801G>A mutation and experienced an ischemic stroke in the left superficial watershed area. Conclusion: The prevalence of undiagnosed Fabry disease in this cohort of Taiwanese young adults with ischemic stroke or TIA was 0.3% among the young male population. Understanding the prevalence of undiagnosed Fabry disease in young adults with ischemic stroke could help shape future Fabry disease screening policies. Data access statement: The collected data will be available upon reasonable request from the corresponding author.