bluuebunny/crossref_metadata_2025_split huggingface dataset:
The liability for employers for the conduct of their employees – when does an employee’s conduct fall within the “the course of employment”?
Authors: Mustafa Engin 
Published: October 2016

Purpose
This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies.

Design/methodology/approach
This briefing is prepared by an independent writer who adds their own impartial comments and places the papers in context.

Findings
All employers need to understand the exposure to risk that their organizations face. In the field of human resource management, the liability of the employer for the actions (or omissions) of an employee is a key part of managing that risk. The scope of such liability is delimited by both statute and case law which has helped clarify the position of employer liability, thereby allowing an employer to mitigate risk.

Practical implications
The paper provides strategic insights and practical thinking that have influenced some of the world’s leading organizations.

Originality/value
The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.
Comparing retrieval of systematic review searches in health sciences areas using two major databases
Authors: Abdulla Arian , Krishnamurthy Mangala 
Published: October 2016

Purpose
Effective literature searches are critical to researchers and health care professionals. To conduct literature searches, clinicians, researchers and nurses rely primarily on a few major databases (PubMed, Cochrane, CINAHL, etc.) to retrieve information. However, there is a lack of literature on the comparative efficiencies of major databases for systematic review results on a clinically related topic. This paper aims to fill that gap in the literature.

Design/methodology/approach
Cochrane Handbook (2011) defines systematic review as a review of a clearly formulated question that uses systematic and explicit methods to identify, select and critically appraise relevant research and to collect and analyze data from the studies that are included in the review. In this paper, search results of systematic reviews on a clinical topic between two major databases – PubMed and Cochrane Library – are compared.

Findings
Searching within PubMed for key terms in the titles and abstracts of articles is important to include in any systematic review, in addition to searching Medical Subject Heading terms. After applying filters, PubMed retrieved 130 systematic reviews that matched the criteria. In Cochrane Library, the searches were performed on the chosen topic using Boolean and phrase searching: text field searches resulted in 251 reviews. The search was further narrowed by subject, which yielded 20 reviews. It is strongly recommended to use multiple health-care specialty databases, check for duplicate reviews in the results and not limit results to English-only publications.

Practical implications
This paper can be used to introduce new researchers and/or students to methods for conducting systematic reviews using two or more databases on a chosen topic.

Originality/value
This paper fills a gap in the literature regarding comparative efficiencies of major databases for systematic review results on clinically related topics.
Through the looking glass: early non-invasive imaging in TBI predicts the need for interventions
Authors: Glaser Jacob , Vasquez Matthew , Cardarelli Cassandra , Galvagno Samuel , Stein Deborah , Murthi Sarah , Scalea Thomas 
Published: October 2016

BackgroundEarly diagnosis and treatment of traumatic brain injury (TBI) lead to better outcomes. It is difficult to predict which patients benefit from specialised centres, leading to over triage or delay in definitive care. We propose that a non-invasive test comprising optic nerve sheath ultrasound, transcranial Doppler and quantitative papillary reactivity is feasible, correlates with CT findings and may allow for accurate early identification of TBI.MethodsA 1-year, prospective observation study evaluated a low-risk, non-invasive method of assessing brain injury. Patients underwent a non-invasive neurological examination for trauma, including the above assessments. Data from the three examinations were collected within 6 hours of injury and at 24 hours, and were analysed. Demographics, haemodynamic data, imaging results and short-term outcomes/interventions were recorded.ResultsTrauma patients over the age of 18 years, with a Glascow coma scale (GCS) of <12 or CT evidence of TBI, and intubated were included (N=100). These were divided into +CT (n=49) and −CT groups (n=51) according to the Marshall CT classification of TBI. The +CT group was older, with worse GCS and higher lactate (p=0.008, p=0.001 and p=0.01) but were otherwise well matched. The +CT group included all TBI types, with 96% of the patients having more than one type of TBI. Pulsatility index and neurologic pupillary index were predictive of a +CT (p=0.04, p=0.02). Area under the receiver-operating curve for the logistic regression model for the prediction of positive radiographic findings was r=0.718. Finally, we suggest a preliminary scoring heuristic for predicting a positive radiological finding in a patient with TBI.ConclusionsThe proposed examination is a feasible, non-invasive tool that may have clinical utility in the early prediction of TBI. If validated, it may improve trauma triage for the brain-injured patient. Further studies are warranted to validate this model.
Woodchip biochar with or without synthetic fertilizers affects soil properties and available phosphorus in two alkaline, chernozemic soils
Authors: Chathurika J.A. Surani , Kumaragamage Darshani , Zvomuya Francis , Akinremi Olalekan O. , Flaten Donald N. , Indraratne Srimathie P. , Dandeniya Warshi S. 
Published: October 2016

Fertility enhancement with biochar application is well documented for tropical acidic soils; however, benefits of biochar coapplied with synthetic fertilizers (SFs) on soil fertility are not well documented, particularly for alkaline chernozems. We examined the short-term interactive effects of woodchip biochar amendment with fertilizers on selected soil properties, available phosphorus (P), and P fractions of two alkaline Chernozems from Manitoba. Treatments were (1) urea and monoammonium phosphate fertilizers, (2) biochar at 10 g kg−1, (3) biochar at 20 g kg−1, (4) biochar at 10 g kg−1with fertilizers, (5) biochar at 20 g kg−1with fertilizers, and (6) a control. Treated soils were analysed for pH, electrical conductivity (EC), and Olsen P concentration biweekly, and for P fractions, cation exchange capacity (CEC), organic carbon (OC), and wet aggregate stability after 70 d of incubation. Biochar amendment without fertilizers significantly increased soil pH and CEC but had no effect on EC, while coapplication with fertilizers significantly increased Olsen P and labile P concentrations. When coapplied with fertilizers, biochar did not significantly increase soil pH relative to the control. Results suggest that biochar improved soil properties and available P in alkaline Chernozems, and the beneficial effects were enhanced when coapplied with SFs.
Experimental study on oblique water entry of projectiles
Authors: Zhao Chenggong , Wang Cong , Wei Yingjie , Zhang Xiaoshi , Sun Tiezhi 
Published: October 2016

An experimental study of oblique water entry of projectiles with different noses has been conducted using high-speed photography technology. The images of the initial water entry impact, cavity evolution, and the closure and shedding of vortices of cavity are presented in the paper. The results reveal that for high-speed oblique water entry (the initial impact velocity [Formula: see text][Formula: see text]50 m/s), the cavity attached to the projectile is symmetrical and free from the influence of gravity. The shedding of the water–vapor–air mixture in the tail of the cavity produces vortices which disappear in the rear of the projectile trajectory. Particular attention is given to the velocity attenuation of the projectile after water entry. The results show that there is a transition point at the time corresponding to the surface seal of the cavity during the velocity attenuation after oblique water entry, and the rates of velocity attenuation are different before and after this transition point. Additionally, the chronophotography of the cavity evolution shows that the time when the surface seal of the cavity occurs decreases with the increase of the initial impact velocity of the projectile.
Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer
Authors: Cook Katherine L. , Soto-Pantoja David R. , Clarke Pamela A.G. , Cruz M. Idalia , Zwart Alan , Wärri Anni , Hilakivi-Clarke Leena , Roberts David D. , Clarke Robert 
Published: October 2016

AbstractThe unfolded protein response is an endoplasmic reticulum stress pathway mediated by the protein chaperone glucose regulated-protein 78 (GRP78). Metabolic analysis of breast cancer cells shows that GRP78 silencing increases the intracellular concentrations of essential polyunsaturated fats, including linoleic acid. Accumulation of fatty acids is due to an inhibition of mitochondrial fatty acid transport, resulting in a reduction of fatty acid oxidation. These data suggest a novel role of GRP78-mediating cellular metabolism. We validated the effect of GRP78-regulated metabolite changes by treating tumor-bearing mice with tamoxifen and/or linoleic acid. Tumors treated with linoleic acid plus tamoxifen exhibited reduced tumor area and tumor weight. Inhibition of either GRP78 or linoleic acid treatment increased MCP-1 serum levels, decreased CD47 expression, and increased macrophage infiltration, suggesting a novel role for GRP78 in regulating innate immunity. GRP78 control of fatty acid oxidation may represent a new homeostatic function for GRP78. Cancer Res; 76(19); 5657–70. ©2016 AACR.
miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3
Authors: Zhou Ying , Dang Jason , Chang Kung-Yen , Yau Edwin , Aza-Blanc Pedro , Moscat Jorge , Rana Tariq M. 
Published: October 2016

Abstract
Global miRNA functional screens can offer a strategy to identify synthetic lethal interactions in cancer cells that might be exploited therapeutically. In this study, we applied this strategy to identify novel gene interactions in KRAS-mutant cancer cells. In this manner, we discovered miR-1298, a novel miRNA that inhibited the growth of KRAS-driven cells both in vitro and in vivo. Using miR-TRAP affinity purification technology, we identified the tyrosine kinase FAK and the laminin subunit LAMB3 as functional targets of miR-1298. Silencing of FAK or LAMB3 recapitulated the synthetic lethal effects of miR-1298 expression in KRAS-driven cancer cells, whereas coexpression of both proteins was critical to rescue miR-1298–induced cell death. Expression of LAMB3 but not FAK was upregulated by mutant KRAS. In clinical specimens, elevated LAMB3 expression correlated with poorer survival in lung cancer patients with an oncogenic KRAS gene signature, suggesting a novel candidate biomarker in this disease setting. Our results define a novel regulatory pathway in KRAS-driven cancers, which offers a potential therapeutic target for their eradication. Cancer Res; 76(19); 5777–87. ©2016 AACR.
Dual Characteristics of Novel HER2 Kinase Domain Mutations in Response to HER2-Targeted Therapies in Human Breast Cancer
Authors: Zuo Wen-Jia , Jiang Yi-Zhou , Wang Yu-Jie , Xu Xiao-En , Hu Xin , Liu Guang-Yu , Wu Jiong , Di Gen-Hong , Yu Ke-Da , Shao Zhi-Ming 
Published: October 2016

Abstract
Purpose: Somatic mutations in the tyrosine kinase domain of human epidermal growth factor receptor 2 (HER2) may be an alternative mechanism to HER2 activation and can affect the sensitivity toward HER2-targeted therapies. We aimed to investigate the prevalence, clinicopathologic characteristics, and functional relevance of novel HER2 mutations in breast cancer.
Experimental Design: We performed Sanger sequencing of all exons of the HER2 gene in 1,248 primary tumors and 18 paired metastatic samples. Novel HER2 mutations were functionally characterized.
Results: The total HER2 somatic mutation rate was 2.24% (28/1,248). Of the seven novel HER2 mutations, L768S and V773L were only detected in HER2-negative tumors, whereas K753E was found in HER2-positive disease. L768S and V773L mutations exhibited a significant increase in tyrosine kinase–specific activity and strongly increased the phosphorylation of signaling proteins in various cell lines. Xenograft experiments showed that NIH3T3 cells bearing the L768S and V773L mutations displayed more rapid growth. MCF10A, BT474, and MDA-MB-231 cells bearing the K753E mutation were resistant to lapatinib, but could be inhibited by neratinib. Finally, comparison of HER2 mutations in 18 pairs of primary and metastatic lesions revealed that the drug-resistant HER2 mutations (K753E and L755S) were enriched in metastatic lesions.
Conclusions: HER2-negative breast cancer with activating mutations can benefit from HER2-targeted therapies. Meanwhile, mutations in the HER2 kinase domain might be a key mechanism of resistance to HER2-targeted therapy, and irreversible tyrosine kinase inhibitors such as neratinib may offer alternative treatment options. Clin Cancer Res; 22(19); 4859–69. ©2016 AACR.
BCL2 Inhibition by Venetoclax: Targeting the Achilles' Heel of the Acute Myeloid Leukemia Stem Cell?
Authors: Pullarkat Vinod A. , Newman Edward M. 
Published: October 2016

Abstract
Summary: Venetoclax is an oral drug with an excellent side-effect profile that has the potential to revolutionize acute myeloid leukemia (AML) therapy in two areas. Venetoclax-based combination therapies could be a bridge to hematopoietic cell transplant with curative intent for patients with refractory/relapsed AML, and venetoclax-based therapy could provide meaningful survival prolongation for older patients with AML who are not candidates for more aggressive therapies. Cancer Discov; 6(10); 1082–3. ©2016 AACR.
See related article by Konopleva and colleagues, p. 1106.
Literature Against Criticism
Authors: Eve Martin Paul 
Published: October 2016

This is a book about the power game currently being played out between two symbiotic cultural institutions: the university and the novel. As the number of hyper-knowledgeable literary fans grows, students and researchers in English departments waiver between dismissing and harnessing voices outside the academy. Meanwhile, the role that the university plays in contemporary literary fiction is becoming increasingly complex and metafictional, moving far beyond the ‘campus novel’ of the mid-twentieth century.
Martin Paul Eve’s engaging and far-reaching study explores the novel's contribution to the ongoing displacement of cultural authority away from university English. Spanning the works of Jennifer Egan, Ishmael Reed, Tom McCarthy, Sarah Waters, Percival Everett, Roberto Bolaño and many others, Literature Against Criticism forces us to re-think our previous notions about the relationship between those who write literary fiction and those who critique it.
Seasonal Variation in Canopy Aerodynamics and the Sensitivity of Transpiration Estimates to Wind Velocity in Broadleaved Deciduous Species
Authors: Barnard D. M. , Bauerle W. L. 
Published: October 2016

Abstract
Characterization of seasonal dynamics in wind speed attenuation within a plant canopy α is necessary for modeling leaf boundary layer conductance , canopy–atmosphere coupling Ω, and transpiration at multiple scales. The goals of this study were to characterize seasonal variation in α in four tree species with canopy wind profiles and a canopy-structure model, to quantify the impact of α on estimates of and Ω, and to determine the influence of variable wind speed on transpiration estimates from a biophysical model [Multi-Array Evaporation Stand Tree Radiation Assemblage (MAESTRA)]. Among species, α varied significantly with above-canopy wind speed and seasonal canopy development. At the mean above-canopy wind speed (1.5 m s−1), α could be predicted using a linear model with leaf area index as the input variable (coefficient of determination R2 = 0.78). However, the canopy-structure model yielded improved predictions (R2 = 0.92) by including canopy height and leaf width. By midseason, increasing canopy leaf area and α resulted in lower within-canopy wind speeds, a decrease in by 20%–50%, and a peak in Ω. Testing a discrete increase in wind speed (0.6–2.4 m s−1; seasonal mean plus/minus one standard deviation) had variable influence on transpiration estimates (from −30% to +20%), which correlated strongly with vapor pressure deficit (R2 = 0.83). Given the importance of α in accurate representation of , Ω, and transpiration, it is concluded that α needs to be given special attention in plant canopies that undergo substantial seasonal changes, especially densely foliated canopies (i.e., leaf area index &gt;1) and in areas with lower native wind speeds (i.e., &lt;2 m s−1).
Do “Brain-Training” Programs Work?
Authors: Simons Daniel J. , Boot Walter R. , Charness Neil , Gathercole Susan E. , Chabris Christopher F. , Hambrick David Z. , Stine-Morrow Elizabeth A. L. 
Published: October 2016

In 2014, two groups of scientists published open letters on the efficacy of brain-training interventions, or “brain games,” for improving cognition. The first letter, a consensus statement from an international group of more than 70 scientists, claimed that brain games do not provide a scientifically grounded way to improve cognitive functioning or to stave off cognitive decline. Several months later, an international group of 133 scientists and practitioners countered that the literature is replete with demonstrations of the benefits of brain training for a wide variety of cognitive and everyday activities. How could two teams of scientists examine the same literature and come to conflicting “consensus” views about the effectiveness of brain training? In part, the disagreement might result from different standards used when evaluating the evidence. To date, the field has lacked a comprehensive review of the brain-training literature, one that examines both the quantity and the quality of the evidence according to a well-defined set of best practices. This article provides such a review, focusing exclusively on the use of cognitive tasks or games as a means to enhance performance on other tasks. We specify and justify a set of best practices for such brain-training interventions and then use those standards to evaluate all of the published peer-reviewed intervention studies cited on the websites of leading brain-training companies listed on Cognitive Training Data ( www.cognitivetrainingdata.org ), the site hosting the open letter from brain-training proponents. These citations presumably represent the evidence that best supports the claims of effectiveness. Based on this examination, we find extensive evidence that brain-training interventions improve performance on the trained tasks, less evidence that such interventions improve performance on closely related tasks, and little evidence that training enhances performance on distantly related tasks or that training improves everyday cognitive performance. We also find that many of the published intervention studies had major shortcomings in design or analysis that preclude definitive conclusions about the efficacy of training, and that none of the cited studies conformed to all of the best practices we identify as essential to drawing clear conclusions about the benefits of brain training for everyday activities. We conclude with detailed recommendations for scientists, funding agencies, and policymakers that, if adopted, would lead to better evidence regarding the efficacy of brain-training interventions.
ChiLin: a comprehensive ChIP-seq and DNase-seq quality control and analysis pipeline
Authors: Qin Qian , Mei Shenglin , Wu Qiu , Sun Hanfei , Li Lewyn , Taing Len , Chen Sujun , Li Fugen , Liu Tao , Zang Chongzhi , Xu Han , Chen Yiwen , Meyer Clifford A. , Zhang Yong , Brown Myles , Long Henry W. , Liu X. Shirley 
Published: October 2016

Abstract
Background
Transcription factor binding, histone modification, and chromatin accessibility studies are important approaches to understanding the biology of gene regulation. ChIP-seq and DNase-seq have become the standard techniques for studying protein-DNA interactions and chromatin accessibility respectively, and comprehensive quality control (QC) and analysis tools are critical to extracting the most value from these assay types. Although many analysis and QC tools have been reported, few combine ChIP-seq and DNase-seq data analysis and quality control in a unified framework with a comprehensive and unbiased reference of data quality metrics.

Results
ChiLin is a computational pipeline that automates the quality control and data analyses of ChIP-seq and DNase-seq data. It is developed using a flexible and modular software framework that can be easily extended and modified. ChiLin is ideal for batch processing of many datasets and is well suited for large collaborative projects involving ChIP-seq and DNase-seq from different designs. ChiLin generates comprehensive quality control reports that include comparisons with historical data derived from over 23,677 public ChIP-seq and DNase-seq samples (11,265 datasets) from eight literature-based classified categories. To the best of our knowledge, this atlas represents the most comprehensive ChIP-seq and DNase-seq related quality metric resource currently available. These historical metrics provide useful heuristic quality references for experiment across all commonly used assay types. Using representative datasets, we demonstrate the versatility of the pipeline by applying it to different assay types of ChIP-seq data. The pipeline software is available open source at https://github.com/cfce/chilin.

Conclusion
ChiLin is a scalable and powerful tool to process large batches of ChIP-seq and DNase-seq datasets. The analysis output and quality metrics have been structured into user-friendly directories and reports. We have successfully compiled 23,677 profiles into a comprehensive quality atlas with fine classification for users.