bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes
Authors: Piontek Uwe , Wallaschofski Henri , Kastenmüller Gabi , Suhre Karsten , Völzke Henry , Do Kieu Trinh , Artati Anna , Nauck Matthias , Adamski Jerzy , Friedrich Nele , Pietzner Maik 
Published: May 2017

AbstractThe role of androgens in metabolism with respect to sex-specific disease associations is poorly understood. Therefore, we aimed to provide molecular signatures in plasma and urine of androgen action in a sex-specific manner using state-of-the-art metabolomics techniques. Our study population consisted of 430 men and 343 women, aged 20–80 years, who were recruited for the cross-sectional population-based Study of Health in Pomerania (SHIP-TREND), Germany. We used linear regression models to identify associations between testosterone, androstenedione and dehydroepiandrosterone-sulfate (DHEAS) as well as sex hormone-binding globulin and plasma or urine metabolites measured by mass spectrometry. The analyses revealed major sex-specific differences in androgen-associated metabolites, particularly for levels of urate, lipids and metabolic surrogates of lifestyle factors, like cotinine or piperine. In women, in particular in the postmenopausal state, androgens showed a greater impact on the metabolome than in men (especially DHEAS and lipids were highly related in women). We observed a novel association of androstenedione on the metabolism of biogenic amines and only a small sex-overlap of associations within steroid metabolism. The present study yields new insights in the interaction between androgens and metabolism, especially about their implication in female metabolism.
Ionic Liquids: evidence of the viscosity scale-dependence
Authors: Berrod Quentin , Ferdeghini Filippo , Zanotti Jean-Marc , Judeinstein Patrick , Lairez Didier , García Sakai Victoria , Czakkel Orsolya , Fouquet Peter , Constantin Doru 
Published: May 2017

AbstractIonic Liquids (ILs) are a specific class of molecular electrolytes characterized by the total absence of co-solvent. Due to their remarkable chemical and electrochemical stability, they are prime candidates for the development of safe and sustainable energy storage systems. The competition between electrostatic and van der Waals interactions leads to a property original for pure liquids: they self-organize in fluctuating nanometric aggregates. So far, this transient structuration has escaped to direct clear-cut experimental assessment. Here, we focus on a imidazolium based IL and use particle-probe rheology to (i) catch this phenomenon and (ii) highlight an unexpected consequence: the self-diffusion coefficient of the cation shows a one order of magnitude difference depending whether it is inferred at the nanometric or at the microscopic scale. As this quantity partly drives the ionic conductivity, such a peculiar property represents a strong limiting factor to the performances of ILs-based batteries.
Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver
Authors: Yoo Ahyoung , Narayan Vikram P. , Hong Eun Young , Whang Wan Kyunn , Park Taesun 
Published: May 2017

AbstractThe present study aimed to investigate whether scopolin exhibits beneficial effects on high-fat diet (HFD)-induced hepatic steatosis in mice. The involvement of sirtuin 1 (SIRT1) as a molecular target for scopolin was also explored. Scopolin decreased the Km of SIRT1 for p53 and nicotinamide adenine dinucleotide without altering Vmax in a cell-free system. Scopolin alleviated oleic acid-induced lipid accumulation and downregulation of SIRT1 activity in HepG2 cells, and these beneficial effects of scopolin were abolished in the presence of SIRT1 inhibitor. Mice administered 0.02% scopolin for 8 weeks exhibited improved phenotypes of HFD-induced hepatic steatosis along with increased hepatic SIRT1 activity and protein expression. Scopolin resulted in increased deacetylation of sterol regulatory element-binding protein 1c with subsequent downregulation of lipogenic genes, and enhanced deacetylation of protein peroxisome proliferator-activated receptor-γ coactivator 1α with upregulation of fatty acid oxidation genes in livers. Scopolin also enhanced deacetylation of nuclear factor-kappa enhancer binding protein and liver kinase B1 (LKB1), facilitating LKB1/AMP-activated protein kinase signaling cascades. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis. Increased hepatic SIRT1 activity and protein expression appeared to be associated with these beneficial effects of scopolin.
A systemic review and an updated meta-analysis: minimally invasive vs open pancreaticoduodenectomy
Authors: Zhao Zhanwei , Yin Zifang , Hang Zhenning , Ji Gang , Feng Quanxin , Zhao Qingchuan 
Published: May 2017

AbstractThe feasible of minimally invasive pancreaticoduodenectomy (MIPD) remains controversial when compared with open pancreaticoduodenectomy (OPD). We conducted a systemic review and meta-analysis to summarise the available evidence to compare MIPD vs OPD. We systemically searched PubMed, EMBASE and Web of Science for studies published through February 2016. The primary endpoint was postoperative pancreatic fistula (POPF, grade B/C). A total of 27 studies involving 14,231 patients (2,377 MIPD and 11,854 OPD) were included. MIPD was associated with longer operative times (P < 0.01) and increased mortality (P < 0.01), but decreased estimated blood loss (P < 0.01), decreased delayed gastric emptying (P < 0.01), increased R0 resection rate (P < 0.01), decreased wound infection (P = 0.03) and shorter hospital stays (P < 0.01). There were no significant differences in BMI (P = 0.43), tumor size (P = 0.17), lymph nodes harvest (P = 0.57), POPF (P = 0.84), reoperation (P = 0.25) and 5-year survival rates (P = 0.82) for MIPD compared with OPD. Although there was an increased operative cost (P < 0.01) for MIPD compared with OPD, the postoperative cost was less (P < 0.01) with the similar total costs (P = 0.28). MIPD can be a reasonable alternative to OPD with the potential advantage of being minimally invasive. However, MIPD should be performed in high-volume centers and more randomized-controlled trials are needed to evaluate the appropriate indications of MIPD.
Hepatocyte SHP-1 is a Critical Modulator of Inflammation During Endotoxemia
Authors: Adhikari Anupam , Martel Caroline , Marette André , Olivier Martin 
Published: May 2017

AbstractLiver hepatocytes (Hep) are known to be central players during the inflammatory response to systemic infection. Interestingly, the protein tyrosine phosphatases (PTP) SHP-1, has been recognized as a major regulator of inflammation; however their implication in the control of Hep-mediated inflammatory response is still unknown. To study its implication in the regulation of the Hep-mediated inflammatory response during endotoxemia, Cre-Lox mice with a Hep-specific Ptpn6 deletion (Ptpn6
H-KO
) were injected with LPS. In contrast to the wild-type mice (Ptpn6
f/f
) that started to die by 24 hrs post-inoculation, the Ptpn6
H-KO
mice exhibited mortality by 6 hrs. In parallel, higher amounts of metabolic markers, pro-inflammatory mediators and circulating cytokines were detected in Ptpn6
H-KO
mice. Primary Hep obtained from Ptpn6
H-KO
, also showed increased secretion of pro-inflammatory cytokines and nitric oxide (NO) comparatively to its wild type (Ptpn6
f/f
) counterpart. Pharmacological approaches to block TNF-α and NO production protected both the Ptpn6
f/f
and the Ptpn6
H-KO
mice against deadly LPS-mediated endotoxemia. Collectively, these results establish hepatocyte SHP-1 is a critical player regulating systemic inflammation. Our findings further suggest that SHP-1 activation could represent a new therapeutic avenue to better control inflammatory-related pathologies.
Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes
Authors: Lei Yang , Guanghui Zhao , Xi Wang , Yingting Wang , Xialu Lin , Fangfang Yu , Goldring Mary B. , Xiong Guo , Lammi Mikko J. 
Published: May 2017

AbstractThe relationship between T-2 toxin and deoxynivalenol (DON) and the risk of Kashin-Beck disease is still controversial since it is poorly known about their selectivity in cartilage damage. We aimed to compare the cytotoxicity of T-2 toxin and DON on cell lines representative of cell types encountered in vivo, including human chondrocytes (C28/I2), human hepatic epithelial cells (L-02) and human tubular epithelial cells (HK-2). In addition, we determined the distribution of T-2 toxin and DON in Sprague-Dawley (SD) rats after a single dose exposure. T-2 toxin or DON decreased proliferation in a time- and concentration-dependent manner and their combination showed a similar antagonistic effect in C28/I2, L-02 and HK-2 cells. Moreover, we observed cell cycle arrest and apoptosis, associated with increased oxidative stress and decline in mitochondrial membrane potential induced by T-2 toxin and/or DON. In vivo study showed that T-2 toxin and DON did not accumulate preferentially in the knee joint compared to liver and kidney after an acute exposure in SD rats. These results suggest that T-2 toxin and/or DON inhibit proliferation and induce apoptosis through a possible mechanism involving reactive oxygen species-mediated mitochondrial pathway that is not specific for chondrocytes in vitro or joint tissues in vivo.
Strain engineered pyrochlore at high pressure
Authors: Rittman Dylan R. , Turner Katlyn M. , Park Sulgiye , Fuentes Antonio F. , Park Changyong , Ewing Rodney C. , Mao Wendy L. 
Published: May 2017

AbstractStrain engineering is a promising method for next-generation materials processing techniques. Here, we use mechanical milling and annealing followed by compression in diamond anvil cell to tailor the intrinsic and extrinsic strain in pyrochlore, Dy2Ti2O7 and Dy2Zr2O7. Raman spectroscopy, X-ray pair distribution function analysis, and X-ray diffraction were used to characterize atomic order over short-, medium-, and long-range spatial scales, respectively, under ambient conditions. Raman spectroscopy and X-ray diffraction were further employed to interrogate the material in situ at high pressure. High-pressure behavior is found to depend on the species and concentration of defects in the sample at ambient conditions. Overall, we show that defects can be engineered to lower the phase transformation onset pressure by ~50% in the ordered pyrochlore Dy2Ti2O7, and lower the phase transformation completion pressure by ~20% in the disordered pyrochlore Dy2Zr2O7. These improvements are achieved without significantly sacrificing mechanical integrity, as characterized by bulk modulus.
Relationship Between Objectively Measured Physical Activity, Cardiovascular Disease Biomarkers, and Hearing Sensitivity Using Data From the National Health and Nutrition Examination Survey 2003–2006
Authors: Loprinzi Paul D. , Joyner Chelsea 
Published: May 2017

Purpose
Limited research has examined the interrelationships among cardiometabolic parameters, physical activity, and hearing function, which was this study's purpose.

Method

Data from the National Health and Nutrition Examination Survey (NHANES) 2003–2006 were used in the path analyses. Physical activity and hearing function were both objectively measured. Various cardiometabolic parameters were assessed from a blood sample. Adults 30–85 years (
N
= 1,070) constituted the analytic sample.

Results

Physical activity was negatively associated with triglycerides (β = −0.11,
p
< .05) and insulin (β = −0.27,
p
< .05); triglycerides (β = 0.01,
p
< .05), and insulin (β = 0.05,
p
< .05) were positively associated with high-frequency pure-tone average (HPTA). The direct path from physical activity to HPTA was nonsignificant (β = 0.01,
p
= .99).

Conclusion
Physical activity was associated with select cardiovascular disease risk factors. Several cardiovascular disease risk factors were associated with hearing function.
Testing the universality of the star-formation efficiency in dense molecular gas
Authors: Shimajiri Y. , André Ph. , Braine J. , Könyves V. , Schneider N. , Bontemps S. , Ladjelate B. , Roy A. , Gao Y. , Chen H. 
Published: May 2017

Context. Recent studies with, for example, Spitzer and Herschel have suggested that star formation in dense molecular gas may be governed by essentially the same “law” in Galactic clouds and external galaxies. This conclusion remains controversial, however, in large part because different tracers have been used to probe the mass of dense molecular gas in Galactic and extragalactic studies.
Aims. We aimed to calibrate the HCN and HCO+ lines commonly used as dense gas tracers in extragalactic studies and to test the possible universality of the star-formation efficiency in dense gas (≳104 cm-3), SFEdense.
Methods. We conducted wide-field mapping of the Aquila, Ophiuchus, and Orion B clouds at ~0.04 pc resolution in the J = 1 − 0 transition of HCN, HCO+, and their isotopomers. For each cloud, we derived a reference estimate of the dense gas mass MHerschelAV > 8, as well as the strength of the local far-ultraviolet (FUV) radiation field, using Herschel Gould Belt survey data products, and estimated the star-formation rate from direct counting of the number of Spitzer young stellar objects.
Results. The H13CO+(1–0) and H13CN(1–0) lines were observed to be good tracers of the dense star-forming filaments detected with Herschel. Comparing the luminosities LHCN and LHCO+ measured in the HCN and HCO+ lines with the reference masses MHerschelAV > 8, the empirical conversion factors αHerschel − HCN (=MHerschelAV > 8/LHCN) and αHerschel − HCO+ (=MHerschelAV > 8/LHCO+) were found to be significantly anti-correlated with the local FUV strength. In agreement with a recent independent study of Orion B by Pety et al., the HCN and HCO+ lines were found to trace gas down to AV ≳ 2. As a result, published extragalactic HCN studies must be tracing all of the moderate density gas down to nH2 ≲ 103 cm-3. Estimating the contribution of this moderate density gas from the typical column density probability distribution functions in nearby clouds, we obtained the following G0-dependent HCN conversion factor for external galaxies: αHerschel − HCNfit′ = 64 × G0-0.34. Re-estimating the dense gas masses in external galaxies with αHerschel − HCNfit′(G0), we found that SFEdense is remarkably constant, with a scatter of less than 1.5 orders of magnitude around 4.5 × 10-8 yr-1, over eight orders of magnitude in dense gas mass.
Conclusions. Our results confirm that SFEdense of galaxies is quasi-universal on a wide range of scales from ~ 1–10 pc to > 10 kpc. Based on the tight link between star formation and filamentary structure found in Herschel studies of nearby clouds, we argue that SFEdense is primarily set by the “microphysics” of core and star formation along filaments.
Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review
Authors: Lee Shing-yan 
Published: May 2017

AbstractIn the treatment of left-sided pulmonary interstitial emphysema (PIE) in a 23-week neonate, we used two ventilatory strategies: selective bronchial intubation from day 10 to 15 and neurally adjusted ventilatory assist (NAVA) from day 18 to 26. We compared the effects and adverse effects of these two strategies. On selective bronchial intubation, desaturation was frequent. Fentanyl infusion was required. There was an episode of carbon dioxide retention coupled with hypotension. On NAVA, the neonate was clinically stable without the requirement of sedation. On selective bronchial intubation, ventilator setting in terms of mean airway pressure and oxygen requirement was higher, which came down on the first day of NAVA. Radiologically unilateral PIE did not resolve and became localized in the left middle zone of lung field on selective bronchial intubation. Also, the lobar collapse of ipsilateral, as well as contralateral lungs occurred. On NAVA, unilateral PIE resolved. NAVA might be a good option for the management of unilateral PIE.
Bildgebende Diagnostik beim akuten Skrotum
Authors: Ring Natalie , Staatz Gundula 
Published: May 2017

ZusammenfassungDas akute Skrotum gehört zu den häufigsten urologischen Notfällen bei Kindern und Jugendlichen und bezeichnet das plötzliche Auftreten von Schmerzen im Skrotum, meist einhergehend mit begleitender Schwellung und Rötung des betroffenen Hodens. Am wichtigsten ist es zunächst festzustellen, ob ein chirurgisches Vorgehen mit Hodenfreilegung notwendig ist, oder ein konservatives Vorgehen gerechtfertigt ist. Da Anamnese und körperliche Untersuchung nicht immer eindeutig sind, kommt ergänzend oft die Sonografie mit farbkodierter Dopplersonografie als Bildgebung der 1. Wahl zum Einsatz. Hiermit gelingt es meist, eine OP-Pflichtige Hodentorsion oder auch eine Hodenruptur nach Trauma von ihren Differenzialdiagnosen, wie z. B. die Hydatidentorsion oder die Epididymorchitis zu unterscheiden. Weiterführende bildgebende Verfahren wie MRT, Szintigrafie oder kontrastmittelverstärkte Sonografie sind nur bei unklaren Fällen oder Komplikationen im Verlauf indiziert.
Papilläres Zystadenom als seltene Differenzialdiagnose einer paratestikulären Raumforderung
Authors: Dräger Désirée , Zonnur Sarah , Erbersdobler Andreas , Protzel Chris , Hakenberg Oliver 
Published: May 2017

ZusammenfassungDas (para-)testikuläre Zystadenom entsteht aus einer oviduktähnlichen Struktur, die morphologisch nahezu identisch mit dem Oberflächenepithel des Ovars ist (Müllerʼsches Epithel). Es ist ein seltener benigner Tumor des Erwachsenenalters mit geringem malignen Potential. Das Durchschnittsalter liegt bei Erstdiagnose in den bisher beschriebenen Fällen bei 30 Jahren (11 – 75 Jahre). In Regel sind es asymptomatische zystische Raumforderungen, die häufig als Rete testis- oder Nebenhodentumoren fehlinterpretiert werden, da makroskopisch nicht sicher identifiziert werden kann, ob sie intra- oder paratestikulär entstanden sind 1. Bilaterale paratestikuläre Zystadenome sind mit dem Von-Hippel-Lindau-Syndrom assoziiert (18 % der von Hippel-Lindau-Patienten) und können aufgrund einer Obstruktion der samenleitenden Gänge mit Infertilität einhergehen 2
3. In der Literatur finden sich nur 12 Publikationen mit 35 berichteten Fällen paratestikulärer Zystadenome aus den Jahren 1986 – 2016, was die Seltenheit dieser Tumorentität verdeutlicht. Obwohl die Mehrheit gutartige Verläufe zeigt, werden aber auch wenige Fälle mit Rezidivbildung und/oder Metastasierung beschrieben, so dass eine Langzeitnachsorge ratsam erscheint 4. Aufgrund der Seltenheit gibt es jedoch keine allgemeinen Empfehlungen zur Therapie. Wir berichten von einem 74-jährigen Patienten mit einem seltenen paratestikulären papillären Zystadenom.
Der Stellenwert von Arbeit und beruflicher Beschäftigung in der Behandlung psychisch kranker Menschen
Authors: Gühne Uta , Stein Janine , Schwarzbach Michaela , Riedel-Heller Steffi 
Published: May 2017

ZusammenfassungDie berufliche Exklusion von Menschen mit (schweren) psychischen Erkrankungen ist beträchtlich. Die Unterstützung beruflicher Teilhabe hier in Deutschland findet vor dem Hintergrund sozialrechtlicher Grundlagen in erster Linie im Bereich der Rehabilitation statt, sollte aber bestenfalls integraler Bestandteil im gesamten Behandlungs- und Rehabilitationsverlauf sein. Die vorliegende qualitative Studie geht der Frage nach, welchen Stellenwert das Thema Arbeit in den einzelnen Behandlungszusammenhängen psychisch kranker Menschen hat. Dazu wurden mit Behandlern (n=44) qualitative Interviews durchgeführt, welche transkribiert und inhaltsanalytisch ausgewertet wurden. Arbeit und berufliche Beschäftigung nehmen lt. Aussage der Befragten einen sehr wichtigen Stellenwert ein und werden bereits im Rahmen der Anamnese frühzeitig erfasst. Die Rollen der Behandler in den unterschiedlichen Versorgungssettings hinsichtlich der Unterstützung der Betroffenen sind vielfältig und individuell ausgerichtet. Spezifische Konzepte und kooperative Strukturen sind nur vereinzelt zu finden.
Kurz- und mittelfristige Wirksamkeit einer störungsspezifischen primären und sekundären Prävention von komorbider Depressivität bei chronischen Rückenschmerzen
Authors: Roch Svenja , Hampel Petra 
Published: May 2017

Zusammenfassung
Einleitung Aufgrund der hohen Komorbiditätsraten von psychischen Störungen bei chronischen Rückenschmerzen wurde ein störungsspezifisches Training zur Schmerzkompetenz und Depressionsprävention für die stationäre verhaltensmedizinisch orthopädische Rehabilitation entwickelt und evaluiert. Dabei wurden die Depressivität und Ängstlichkeit sowie schmerzbezogene Parameter untersucht.
Methode In den per protocol-Analysen wurden mit den Daten von n=723 Rehabilitanden Regressionsanalysen zur Evaluation des Trainings durchgeführt. Die intraindividuellen Veränderungen wurden mit Cohens d basierend auf Varianzanalysen mit Messwiederholung quantifiziert. Die Ergebnisse der Regressionsanalysen wurden mit n=1306 multipel imputierten Daten validiert.
Ergebnisse Die Rehabilitanden profitierten in allen Kennwerten kurz- und mittelfristig (6 Monate nach der Intervention) von der Rehabilitation sowohl mit als auch ohne zusätzliches Depressionspräventionstraining. Dabei war die Depressivität zu Rehabilitationsbeginn ein signifikanter Prädiktor für alle betrachteten Kriterien und das Depressionspräventionstraining konnte die geringste Schmerzintensität zu Rehabilitationsende unabhängig von der Depressivität zu Rehabilitationsbeginn reduzieren. Die Ergebnisse wurden durch die Analysen nach multipler Imputation bestätigt. Besonders in der Depressivität und Ängstlichkeit kam es in den ersten Monaten nach der Rehabilitation jedoch zu einem Rückgang der erzielten Verbesserungen.
Diskussion Die Ergebnisse untermauern den Einfluss der Depressivität auf die psychologischen und schmerzbezogenen Kennwerte. Dies spricht für die Relevanz der frühzeitigen Behandlung der depressiven Symptome. Allerdings zeigte das ergänzende Depressionspräventionstraining im Rahmen der stationären Rehabilitation keinen zusätzlichen Effekt, was auf die großen Effektstärken des alleinigen Schmerzkompetenztrainings zurückzuführen sein könnte. Zudem sollten die erzielten Verbesserungen durch geeignete Nachsorgemaßnahmen stabilisiert werden, da rückläufige Effekte 6 Monate nach der Rehabilitation zu verzeichnen waren.