bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus
Authors: Xu Linlin , Tao Xiangchen , Li Zhiwei , Xu Yanyun , Zhu Wei , Xu Huijuan , Pu Wei , Xie Yi , Mu Guoying 
Published: September 2017

Objectives:
To evaluate the safety and efficacy of mitomycin C (MMC) in haze formation after ultraviolet A/riboflavin corneal crosslinking (CXL) for progressive keratoconus.

Methods:
A total of 60 keratoconic eyes of 48 patients were enrolled in this prospective comparative study after obtaining informed consent. In the CXL group, standard corneal CXL was performed, whereas in the CXL+MMC group, 0.02% MMC was used for 30 s soon after CXL. Comprehensive ophthalmologic examinations were performed on all patients before surgery and at 1, 3, 6, and 12 months after surgery.

Results:
The epithelium recovered within 3 to 4 days after CXL, and the healing time was comparable in the two groups. There was no significant endothelial cell density loss after CXL in both groups. Eyes in both groups showed improvement of uncorrected distance visual acuity (Snellen) and best-corrected visual acuity (Snellen; P<0.05), and there was a decrease in K-max, cylinder degree, and central corneal thickness (CCT) (P<0.05). There was no significant statistical difference between the groups regarding postoperative K-max reduction, refraction, and CCT (P>0.05). Corneal haze scores were significantly higher in the CXL group at 1 and 3 months after CXL (P=0.012 and P=0.028, respectively), but were similar to the MMC group at 6 and 12 months after surgery (P=0.329 and P=0.543, respectively).

Conclusions:
Prophylactic intraoperative use of 0.02% MMC can significantly reduce CXL-associated haze formation, especially in the early postoperative period, and no signs of weakening CXL efficacy were observed.
A Mixed-Methods Study of Unmet Supportive Care Needs Among Head and Neck Cancer Survivors
Authors: So Winnie K.W. , Wong Cho-Lee , Choi Kai-Chow , Chan Carmen W.H. , Chan Joanne C.Y. , Law Bernard M.H. , Wan Rayman W.M. , Mak Suzanne S.S. , Ling Wai-Man , Ng Wai-Tong , Yu Bernice W.L. 
Published: September 2017

Background
Head and neck cancer (HNC) survivors face increasing challenges to adjust to the diagnosis and late effects of treatment. Identifying unmet needs among HNC survivors is therefore important to provide a comprehensive supportive care service for them.

Objective
The aim of this study was to examine the unmet supportive care needs (SCNs) of HNC survivors in the first year after treatment.

Methods
An explanatory sequential mixed-method design with 2 phases was used. In the quantitative phase, standardized questionnaires were administered to 285 Chinese HNC survivors to solicit their demographic and clinical characteristics, unmet SCNs, and access to various support services. In the qualitative phase, individual semistructured interviews were conducted with 53 participants to explore their unmet needs in more detail.

Results
The most prevalent unmet SCNs among the survivors were in the health system and information domain. Five categories of unmet needs emerged from the interview data: physical, psychological, health system and information, patient care and support, and sexuality. The findings reflect the inadequacy of the healthcare services for these survivors.

Conclusion
Chinese HNC survivors experienced a variety of unmet SCNs, particularly in the areas of symptom management and healthcare system and information provision.

Implications for Practice
The study provides insights that can (1) inform future service development, including regular symptom identification and management, improvements in communication, and counseling services and (2) identify the specific needs of these survivors as the basis for tailoring care to meet their needs.
Photon-Counting CT
Authors: Mannil Manoj , Hickethier Tilman , von Spiczak Jochen , Baer Matthias , Henning André , Hertel Madeleine , Schmidt Bernhard , Flohr Thomas , Maintz David , Alkadhi Hatem 
Published: September 2017

Purpose
The aim of this study was to investigate computed tomography (CT) imaging characteristics of coronary stents using a novel photon-counting detector (PCD) in comparison with a conventional energy-integrating detector (EID).

Materials and Methods
In this in vitro study, 18 different coronary stents were expanded in plastic tubes of 3 mm diameter, were filled with contrast agent (diluted to an attenuation of 250 Hounsfield units [HU] at 120 kVp), and were sealed. Stents were placed in an oil-filled custom phantom calibrated to an attenuation of −100 HU at 120 kVp for resembling pericardial fat. The phantom was positioned in the gantry at 2 different angles at 0 degree and 90 degrees relative to the z axis, and was imaged in a research dual-source PCD-CT scanner. Detector subsystem “A” used a standard 64-row EID, while detector subsystem “B” used a PCD, allowing high-resolution scanning (detector pixel-size 0.250 × 0.250 mm in the isocenter). Images were obtained from both detector systems at identical tube voltage (100 kVp) and tube current-time product (100 mA), and were both reconstructed using a typical convolution kernel for stent imaging (B46f) and using the same reconstruction parameters. Two independent, blinded readers evaluated in-stent visibility and measured noise, intraluminal stent diameter, and in-stent attenuation for each detector subsystem. Differences in noise, intraluminal stent diameter, and in-stent attenuation where tested using a paired t test; differences in subjective in-stent visibility were evaluated using a Wilcoxon signed-rank test.

Results
Best results for in-stent visibility, noise, intraluminal stent diameter, and in-stent attenuation in EID and PCD were observed at 0-degree phantom position along the z axis, suggesting higher in-plane compared with through-plane resolution. Subjective in-stent visibility was superior in coronary stent images obtained from PCD compared with EID (P < 0.001). Mean in-stent diameter was 28.8% and 8.4% greater in PCD (0.85 ± 0.24 mm; 0.83 ± 0.14 mm) as compared with EID acquisitions (0.66 ± 0.21 mm; 0.76 ± 0.13 mm) for both 0-degree and 90-degree phantom positions, respectively. Average noise was significantly lower (P < 0.001) for PCD (5 ± 0.2 HU) compared with EID (8.3 ± 0.2 HU). The increase in in-stent attenuation (0 degree: Δ 245 ± 163 HU vs Δ 156.5 ± 126 HU; P = 0.006; 90 degrees: Δ 194 ± 141 HU vs Δ 126 ± 78 HU; P = 0.001) was significantly lower for PCD compared with EID acquisitions.

Conclusions
At matched CT scan protocol settings and identical image reconstruction parameters, the PCD yields superior in-stent lumen delineation of coronary artery stents as compared with conventional EID arrays.
The Visual Agnosias and Related Disorders
Authors: Haque Sameen , Vaphiades Michael S. , Lueck Christian J. 
Published: September 2017

Background:
There are many disorders of higher visual processing that result from damage to specific areas of the cerebral cortex that have a specific role in processing certain aspects (modalities) of vision. These can be grouped into those that affect the ventral, or “what?”, pathway (e.g., object agnosia, cerebral achromatopsia, prosopagnosia, topographagnosia, and pure alexia), and those that affect the dorsal, or “where?”, pathway (e.g., akinetopsia, simultanagnosia, and optic ataxia).

Evidence Acquisition:
This article reviews pertinent literature, concentrating on recent developments in basic science research and studies of individual patients.

Results:
An overview of the current understanding of higher cerebral visual processing is followed by a discussion of the various disorders listed above.

Conclusions:
There has been considerable progress in the understanding of how the extrastriate visual cortex is organized, specifically in relation to functionally specialized visual areas. This permits a better understanding of the individual visual agnosias resulting from damage to these areas.
Systematic identification of cancer-specific MHC-binding peptides with RAVEN
Authors: Baldauf Michaela C. , Gerke Julia S. , Kirschner Andreas , Blaeschke Franziska , Effenberger Manuel , Schober Kilian , Rubio Rebeca Alba , Kanaseki Takayuki , Kiran Merve M. , Dallmayer Marlene , Musa Julian , Akpolat Nurset , Akatli Ayse N. , Rosman Fernando C. , Özen Özlem , Sugita Shintaro , Hasegawa Tadashi , Sugimura Haruhiko , Baumhoer Daniel , Knott Maximilian M. L. , Sannino Giuseppina , Marchetto Aruna , Li Jing , Busch Dirk H. , Feuchtinger Tobias , Ohmura Shunya , Orth Martin F. , Thiel Uwe , Kirchner Thomas , Grünewald Thomas G. P. 
Published: September 2017

ABSTRACTImmunotherapy can revolutionize anti-cancer therapy if specific targets are available. Recurrent somatic mutations in the exome can create highly specific neo-antigens. However, especially pediatric cancers are oligo-mutated and hardly exhibit recurrent neo-antigens. Yet, immunogenic peptides encoded by cancer-specific genes (CSGs), which are virtually not expressed in normal tissues, may enable a targeted immunotherapy of such cancers. Here, we describe an algorithm and provide a user-friendly software named RAVEN (Rich Analysis of Variable gene Expressions in Numerous tissues), which automatizes the systematic and fast identification of CSG-encoded peptides highly affine to Major Histocompatibility Complexes (MHC) starting from publicly available gene expression data. We applied RAVEN to a dataset assembled from more than 2,700 simultaneously normalized gene expression microarrays comprising 50 tumor entities, with a focus on sarcomas and pediatric cancers, and 71 normal tissue types. RAVEN performed a transcriptome-wide scan in each cancer entity for gender-specific CSGs. As a proof-of-concept we identified several established CSGs, but also many novel candidates potentially suitable for targeting multiple cancer types. The specific expression of the most promising CSGs was validated by qRT-PCR in cancer cell lines and by immunohistochemistry in a comprehensive tissue-microarray comprising 412 samples. Subsequently, RAVEN identified likely immunogenic peptides encoded by these CSGs by predicting the affinity to MHCs. Putative highly affine peptides were automatically crosschecked with the UniProt protein-database to exclude sequence identity with abundantly expressed proteins. The predicted affinity of selected peptides was validated in T2-cell peptide-binding assays in which many showed similar kinetics to a very immunogenic influenza control peptide.Collectively, we provide a comprehensive, exquisitely curated and validated catalogue of cancer-specific and highly MHC-affine peptides across 50 cancer entities. In addition, we developed an intuitive and freely available software to easily apply our algorithm to any gene expression dataset (https://github.com/JSGerke/RAVENsoftware). We anticipate that our peptide libraries and software constitute a rich resource to accelerate the development of novel immunotherapies.
Human Ageing Genomic Resources: 2018 Update
Authors: Tacutu Robi , Thornton Daniel , Johnson Emily , Budovsky Arie , Barardo Diogo , Craig Thomas , Lehmann Gilad , Toren Dmitri , Fraifeld Vadim E. , de Magalhães João Pedro 
Published: September 2017

AbstractIn spite of a growing body of research and data, human ageing remains a poorly understood process. To facilitate studies of ageing, over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), which are now the leading online resource for biogerontologists. In this update, we present HAGR’s main functionalities, including new additions and improvements to HAGR. HAGR consists of five databases: 1) the GenAge database of ageing-related genes, in turn composed of a dataset of >300 human ageing-related genes and a dataset with >2000 genes associated with ageing or longevity in model organisms; 2) the AnAge database of animal ageing and longevity, featuring >4000 species; 3) the GenDR database with >200 genes associated with the life-extending effects of dietary restriction; 4) the LongevityMap database of human genetic association studies of longevity with >500 entries; 5) the DrugAge database with >400 ageing or longevity-associated drugs or compounds; 6) the CellAge database with >200 genes associated with cell senescence. All our databases are manually curated by experts to ensure a high quality data and presented in an intuitive and clear interface that includes cross-links across our databases and to external resources. HAGR is freely available online (http://genomics.senescence.info/).
Phage therapy of corrosion-producing bacterium Stenotrophomonas maltophilia using isolated lytic bacteriophages
Authors: Pedramfar Arezoo , Beheshti Maal Keivan , Mirdamadian Sayed Hossein 
Published: September 2017

Purpose
Corrosion-producing microorganisms have different physiology and include sulfate-reducing bacteria, iron oxidizers and magnesium oxidizers. Biocorrosion has been seen in various industries, especially the petrochemicals and oil industries. One proposal to solve this problem is the use of bacteriophages to treat the bacteria-caused corrosion. The aims of this study were isolation and identification of corrosion-producing bacteria from petroleum pipeline corrosion as well as finding their specific bacteriophages for phage therapy purposes.

Design/methodology/approach
The sample pipes with the corrosion were obtained from the Gandomkar petroleum pipeline station, Chaharmahal and Bakhtiari, Iran. For screening the corrosion-producing bacteria, the rusted pipe samples were cultured in a selective culture medium, manganese agar. The purified individual colonies were subjected to molecular examinations. For isolating bacteriophages from silversmithing workshops wastewater in Isfahan, whole plate titration methods and transmission electron microscopy were used to isolate and detect phages.

Findings
The cultivation of corrosion-based material on manganese agar after 18 hours incubation at 30°C resulted in the isolation of cream-colored colonies. The microscopic examinations showed Gram-negative coccobacilli. Based on molecular examinations, the isolated bacteria were identified as Stenotrophomonas maltophilia strain PBM-IAUF-2 with Genebank accession number of KU145278.1. The found bacteriophage was related to the Siphoviridae family of phages.

Originality/value
This paper is the first report of isolation and identification of corrosion-producing bacteria and its specific lytic phages from Gandomkar petroleum pipeline station, Chaharmahal and Bakhtiari, Iran. The biological procedures for preventing the microbial corrosion could be an asset and considered as a potential in the petroleum and industrial microbiology. Phage therapy is considered as one of the economical methods for reducing the biocorrosion.
Unconventional fluoride conversion coating preparation and characterization
Authors: Drábiková Juliána , Fintová Stanislava , Tkacz Jakub , Doležal Pavel , Wasserbauer Jaromír 
Published: September 2017

Purpose
The purpose of this paper is to compare electrochemical corrosion characteristics of conventional and unconventional fluoride conversion coating prepared on magnesium alloy.

Design/methodology/approach
The chemical reaction of AZ61 with 38 wt.% hydrofluoric acid (HF) for 24 h was used as a conventional way of fluoride conversion coating preparation. The unconventionally prepared coating was created in Na[BF4] salt melt at 450°C for 2 h. Morphology and chemical composition of prepared fluoride conversion coatings were studied with scanning electron microscopy and energy-dispersive X-ray spectroscopy. Electrochemical corrosion characteristics of the coatings were analyzed in Hank’s solution using potentiodynamic tests.

Findings
Both the coating preparation ways resulted in the creation of uniform conversion coatings with the same thickness (1.3 ± 0.1 μm). Some defects were observed on the coatings surface; however, the defects did not reach the AZ61 surface. Electrochemical tests performed in Hank’s solution at 37°C showed an improvement of corrosion resistance of AZ61 treated with fluoride conversion coatings when compared to the untreated material. Unconventionally prepared coating reached better electrochemical corrosion characteristics when compared to the conventionally prepared coating.

Originality/value
Electrochemical corrosion characteristics of AZ61 magnesium alloy can be improved with fluoride conversion coatings. Two methods are used in the literature for the coatings preparation. The conventional method is based on dipping of the coated material to the HF, and the unconventional method lies in dipping of the sample to the Na[BF4] salt melt. The main purpose of the present study is to analyze the conventionally and unconventionally prepared coatings in terms of chemical analysis, morphology and material corrosion protection (electrochemical corrosion characteristics), while the data are not provided in the literature, according to the authors’ knowledge. Very similar coatings were prepared using both the methods from the morphological and chemical composition point of view. However, unconventionally prepared coating created in Na[BF4] salt melt reached better electrochemical corrosion characteristics compared to the coating prepared in HF.
The combined erosion and corrosion resistance of WC-Ni vacuum brazed coating
Authors: Joo Hyung Goun , Lee Kang Yong , Luo Guo Ming , Zhang Da Quan 
Published: September 2017

Purpose
The purpose of this paper is to investigate the combined erosion and corrosion behavior of WC-Ni vacuum brazed coating.

Design/methodology/approach
Al2O3 particles and 10 wt% NaCl solution are used to evaluate erosion and corrosion resistance of WC-Ni vacuum brazed coating. Combined test of erosion and corrosion is also conducted. The microstructure of each specimen is characterized by the scanning electron microscopy. The chemical composition was determined by energy-dispersive X-ray spectroscopy.

Findings
WC-Ni vacuum brazed coating layer is effective protective coating under combined erosion and corrosion environment. The weight loss of coating layer is more reduced as the cumulative test time.

Originality/value
WC-Ni vacuum brazed coatings are investigated to check characteristic of the combined erosion and corrosion environment. WC-Ni vacuum brazed coatings are kind of diffusion coating that attract attention because of the resistance of superb impact and corrosion in comparison with other coatings. Some previous researches reported the properties of vacuum brazed WC material. Erosion and corrosion behaviors of WC-Ni vacuum brazed coatings were studied in our previous research, respectively. Hence, in this research, the principal objective is to examine the combined erosion and corrosion behavior of WC-Ni vacuum brazed coating.
Why leadership style matters: a closer look at transformational leadership and internal marketing
Authors: Akbari Morteza , Seyyed Amiri Nader , Imani Saheb , Rezaeei Niloofar , Foroudi Pantea 
Published: September 2017

Purpose
The main purpose of this study is to evaluate the relationship between transformational leadership (TL) and internal marketing which is underscored by the centrality of human resources in satisfying employee’s needs and how internal marketing, as a moderator and mediator, can facilitate the effects of transformational leadership on social capital and employee loyalty.

Design/methodology/approach
This study develops a model and a number of propositions based on preceding literature on transformational leadership and internal marketing on social capital and employee loyalty.

Findings
The model proposes that transformational leadership can play a vital role in codification of human resources variables such as internal marketing, which is founded upon the principle of paying greater attention to employees. Moreover, despite the research gap on the relationship between social capital and employee loyalty, it can be concluded that social capital can increase the level of employee loyalty to organization.

Research limitations/implications
The proposed model has a number of academic and managerial contributions. This study contributes the knowledge by examining the relationship between transformational leadership and internal marketing. Managerially, this study helps managers to emphasize the centrality of human resources in satisfying employees and increase their loyalty toward the company. In addition, guarantees management effectiveness and organizational success in reaching their intended goals.

Originality/value
Despite the growing acknowledgment the importance of transformational leadership as a process in which leaders and followers upgrade each other’s level of ethic and motivation. However, there are few studies on the role and importance of transformational leadership on developing and reinforcing the internal marketing.
Relevant factors of innovation contests for SMEs
Authors: Rodriguez Ferradas Maria Isabel , Alfaro Tanco José A. , Sandulli Francesco 
Published: September 2017

Purpose
The purpose of this paper is to explore the relevant factors that influence the implementation of innovation contests, an open innovation (OI) practice that has been extensively reported in the literature as a managerial tool for external knowledge search. The authors focus the study on the context of small and medium enterprises (SMEs).

Design/methodology/approach
The approach is a retrospective case study. This methodology allows an in-depth view into a Spanish SME that successfully undertook two new product development processes thanks to the deployment of innovation contests.

Findings
The main context factors influencing innovation contests as managerial tool are ambidexterity, technological and marketing turbulence and intermediaries, among others. Regarding design factors, this work highlights the role of attraction and facilitation. Additionally, the repetitive implementation of innovation contests creates a corporate culture that promotes OI activities.

Practical implications
Managers will understand that they can use innovation contests as a managerial tool, and knowing the factors that need to be taken into account when implementing an innovation contest will help SMEs managers to make better use of this practice.

Originality/value
This case study enriches the literature of both innovation contests and topics relevant to SMEs. Based on a theoretical framework of the design factors that influence the implementation of innovation contests, the authors propose a research framework that incorporates those context factors in association with an SME.