bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of a professional development workshop on healthcare professionals’ knowledge and readiness to use telehealth etiquette in virtual care
Authors: Pittmann Rachel , Danaher-Garcia Nicole , Adair White Bobbie Ann , Thompson Anne 
Published: October 2024

Introduction Telehealth is a growing part of the healthcare field, and healthcare professionals and trainees require training not only on the clinical skills relevant to telehealth but also on professionalism skills or telehealth etiquette. As healthcare outcomes are influenced by the patient-provider relationship, training healthcare professionals on telehealth etiquette skills is imperative. Methods Forty-eight healthcare professionals across different disciplines, work settings, and experience levels participated in a telehealth etiquette skills educational intervention workshop wherein their knowledge and readiness to use the skills (specific to technology, environment, confidentiality, and communication) were assessed before and after the workshop. Results Paired sample t-tests revealed that participating in the educational intervention resulted in statistically significant improvements in knowledge and perceived readiness to use telehealth etiquette skills pertinent to technology, environment, and communication. There were no associations between participants’ personal factors and post-educational intervention changes. Discussion Study findings are significant and suggest that training healthcare professionals in telehealth etiquette have a positive impact. Since there is a known positive association between provider communication and patient satisfaction and a known association between patient satisfaction and healthcare outcomes, gaining telehealth etiquette skills is critical for promoting a positive patient-provider relationship via telehealth.
Quantifying patients’ preferences on tradeoffs between mortality risk and reduced need for target vessel revascularization for claudication
Authors: Reed Shelby D , Sutphin Jessie , Wallace Matthew J , Gonzalez Juan Marcos , Yang Jui-Chen , Reed Johnson F , Tsapatsaris Jennifer , Tarver Michelle E , Saha Anindita , Chen Allen L , Gebben David J , Malone Misti , Farb Andrew , Babalola Olufemi , Rorer Eva M , Parikh Sahil A , Simons Jessica P , Jones W Schuyler , Krucoff Mitchell W , Secemsky Eric A , Corriere Matthew A 
Published: October 2024

Background: In 2019, the US Food and Drug Administration issued a warning that symptomatic relief from claudication using paclitaxel-coated devices might be associated with an increase in mortality over 5 years. We designed a discrete-choice experiment (DCE) to quantify tradeoffs that patients would accept between a decreased risk of clinically driven target-vessel revascularization (CDTVR) and increased mortality risk. Methods: Patients with claudication symptoms were recruited from seven medical centers to complete a web-based survey including eight DCE questions that presented pairs of hypothetical device profiles defined by varying risks of CDTVR and overall mortality at 2 and 5 years. Random-parameters logit models were used to estimate relative preference weights, from which the maximum-acceptable increase in 5-year mortality risk was derived. Results: A total of 272 patients completed the survey. On average, patients would accept a device offering reductions in CDTVR risks from 30% to 10% at 2 years and from 40% to 30% at 5 years if the 5-year mortality risk was less than 12.6% (95% CI: 11.8–13.4%), representing a cut-point of 4.6 percentage points above a baseline risk of 8%. However, approximately 40% chose the device alternative with the lower 5-year mortality risk in seven (20.6%) or eight (18.0%) of the eight DCE questions regardless of the benefit offered. Conclusions: Most patients in the study would accept some incremental increase in 5-year mortality risk to reduce the 2-year and 5-year risks of CDTVR by 20 and 10 percentage points, respectively. However, significant patient-level variability in risk tolerance underscores the need for systematic approaches to support benefit-risk decision making.
Phrasal verb production in child heritage speakers of English residing in Mexico: Chronological age, experience, and protracted development
Authors: Cuza Alejandro 
Published: October 2024

Aims: We investigated the extent to which child heritage speakers of English in contact with Spanish in Mexico accurately produce phrasal verbs, and if not, whether their difficulties are modulated by chronological age, language dominance, and experience. Methods: We implemented an elicited production task to elicit the use of idiomatic and transparent phrasal verbs in school-age children using a cross-sectional design. We tested 26 English-heritage children and adolescents (7.5–17.3; M = 10.4) residing in Mexico. Their results were compared with those of 18 English monolingual children born and raised in the American Midwest (6.11–14.9, M = 10.2). Chronological age, dominance, and patterns of language experience were included as covariables. Data and Analysis: Data were analyzed using generalized linear mixed models with binomial distribution. Findings: The heritage children exhibited significant difficulties in accurately using phrasal verbs compared with monolingual children, particularly with idiomatic phrases, revealing an asymmetry between the two structure types. Difficulties were modulated by age and linguistic experience. Importantly, as children aged and experienced extended exposure to English, the observed challenges diminished, aligning with recent findings in heritage language development. We posit that these divergences are attributed to protracted development during childhood. Originality: This study expands on recent work with adult heritage speakers of English by tracking the development of phrasal verbs in school-age children quasi-longitudinally rather than observing the adult-like outcome. Furthermore, examining young and older school-age heritage speakers of English in contact with Spanish as the dominant language in Mexico contributes to existing research primarily centered on heritage speakers of minoritized languages in the United States.
Social work research culture in Australian university settings
Authors: Hughes Mark , Tilbury Clare , Hitchcock Clarissa , Bigby Christine 
Published: October 2024

Summary There has been increased attention on the performance of social work researchers and strategies for strengthening the connection between research and practice. However, little is known about the research culture of social work discipline groups within universities and what contributes to a sustainable high-performance culture. Twenty experienced social work researchers from Australian universities were recruited and participated in qualitative interviews. Informed by a critical realist perspective, participants shared what they perceive as influencing social work research culture in university settings. Findings Participants reflected on the beliefs, values, and behaviors contributing to a positive research culture in universities and social work discipline groups. Four key themes were developed: research culture is enhanced when there is a cadre of research-qualified staff; collaboration enhances research culture; time for research needs to be protected; and the professional narrative about social work research influences research culture in universities. Precarious employment for research staff, limited focus on research training in social work qualifying degrees and workloads that focus primarily on administration and teaching were seen as inhibitors of research culture. Applications Attracting and retaining high-performing social work researchers assist in setting benchmarks for research performance, strengthening the quality and purpose of research training, supporting junior colleagues to navigate research systems, and creating opportunities for collaboration. While multidisciplinary collaborations within a particular field can sometimes detract from a focus on research culture in social work, they can also raise performance expectations and strengthen positioning for competitive grants.
Industrial-scale needle-less electrospinning of tetracycline-immobilized nanofibrous scaffolds using a polycaprolactone/polyethylene oxide/chitosan blend for wound healing
Authors: Lubasova Daniela , Tomankova Hana , Polakova Dagmar 
Published: October 2024

Nanofibrous scaffolds offer significant promise for wound healing due to their ability to absorb exudates, prevent microbial contamination, and enhance oxygen diffusion. However, challenges remain in fully realizing their clinical potential, as previous research has primarily focused on scaffolds made of two polymers or those encapsulating therapeutic agents within nanofibers. Additionally, scaling up fabrication while maintaining functionality presents a significant challenge. This study introduces a novel type of nanofibrous scaffold, combining poly (ethylene oxide) (PEO), poly (caprolactone) (PCL), and chitosan (CS) in various mass ratios, electrospun using Nanospider™ technology. The scaffolds featured fiber diameters ranging from 134 ± 37 to 148 ± 38 nm and exhibit high gram-per-square-meter values between 6.8 and 8.6 g/m2. An optimal balance of hydrophilicity was achieved, and the scaffolds demonstrated superior breathability with moisture vapor transmission rates ranging from 1904.3 ± 28.6 to 2005.7 ± 42.9 g/m2/day, outperforming commercial wound dressings. Additionally, a wide range of hydrolytic degradation rates (3.8 ± 1% to 73.2 ± 0.8%), elongation at fracture (21% to 0.8%), and Young’s modulus (106.7 ± 8.5 MPa to 170.7 ± 11.9 MPa) were observed. Surface-immobilized tetracycline (TET) significantly enhanced antibacterial efficacy, with inhibition zones exceeding 20 mm against Escherichia coli. Our findings confirm that scaffold properties can be effectively tailored by adjusting the PEO/PCL ratio, advancing customization for wound care. Post-fabrication soaking in TET solutions further boosts antibacterial performance and allows for tailored post-production adjustments. Compared to existing studies, this approach simplifies customization and improves the practicality of wound care solutions.
A dementia education programme for pre-registration nurses: a protocol for process and outcomes evaluation
Authors: Harkin Deirdre , Conway Aoife , Ryan Assumpta 
Published: October 2024

Background: Dementia’s increasing prevalence, particularly among the ageing population, highlights the urgent need for specialised care. Nurses play a critical role, but often lack sufficient training, leading to low confidence in dementia care. The Dementia Education Programme (DEP) was launched to address this, offering a multi-level curriculum for student nurses. Aims: This paper presents a protocol for evaluating the DEP for nursing students. This study aims to assess the programme’s impact on students’ knowledge, attitudes and confidence while exploring the mechanisms influencing the programme’s implementation and effectiveness. Methods: The protocol employs a dual-fold evaluation, incorporating outcomes and process evaluation. The study uses a mixed-methods strategy, specifically a sequential explanatory design. Quantitative data are gathered longitudinally at four time points using validated instruments to assess knowledge, attitudes and confidence. Based on the results of the quantitative analysis, qualitative data is then collected through interviews and detailed field notes. Results: The DEP is described in detail, emphasising essential elements and underpinning theories. The protocol addresses ethical considerations as well as possible strengths and weaknesses of the study. Conclusions: By combining quantitative and qualitative methods, the research aims to provide a comprehensive evaluation, informing future educational practices and policy development in dementia care.
Patient-reported outcomes in research on critically ill obstetric patients
Authors: Viau Lapointe Julien , Juando-Prats Clara , Zapata Roberto , Kfouri Julia , Ortuno-Nacho Joyamor , Ashraf Rizwana , D’Souza Rohan , Rojas-Suarez Jose , Lapinsky Stephen E 
Published: October 2024

Background Research benefits from the incorporation of patient-important outcomes. We interviewed individuals after a critical illness during pregnancy to identify outcomes for the development of a core outcome set (COS). Methods Participants were identified through intensive care unit (ICU) admissions in Toronto, Canada, and Barranquilla, Colombia. Interviewers used a semi-structured guide, and discussions were recorded and transcribed. Transcripts underwent inductive thematic analysis to delineate themes and patient-important outcomes. Results Twelve individuals were interviewed. Twenty-six patient-important outcomes were elicited, which represented the core outcome areas of mortality ( n = 1), physiological/clinical outcomes ( n = 7), functioning and life impact ( n = 13), resource use ( n = 4) and adverse events ( n = 1). These related to five identified themes of mental well-being, quality of care delivered, clinicians’ communication, regaining functional independence and mother–newborn separation. Conclusions This qualitative study identified patient-important outcomes from persons with lived experience of critical illness in pregnancy which will inform the development of a COS.
Carriage of the HLA-DQA1⋆05 haplotype is associated with a higher risk of infratherapeutic drug concentration and higher immunogenicity in patients undergoing treatment with anti-TNF for inflammatory bowel disease
Authors: Navajas Hernández Pilar , Mouhtar el Halabi Samer , González Parra Ana Caridad , Valdés Delgado Teresa , Maldonado Pérez Belén , Castro Laria Luisa , Charpentier Cloé , Argüelles-Arias Federico 
Published: October 2024

Background: The success of anti-tumor necrosis factor (TNF) drug strategies in the treatment of inflammatory bowel disease (IBD) is altered by the development of anti-drug antibodies that reduce their efficacy. Studies have shown that the HLA-DQA1⋆05 allele increases the risk of immunogenicity to anti-TNF drugs approximately twofold. Objective: Analyze whether the presence of the HLA-DQA1⋆05 allele is associated with the development of immunogenicity and to evaluate the disease response to anti-TNF drugs (infliximab (IFX) and adalimumab (ADA)), according to the presence of this allele. Design: This is an observational retrospective cohort study, single center, to determine the impact of HLA-DQA1⋆05 on disease activity in patients with IBD at the Hospital Universitario Virgen Macarena. Methods: In total, 200 IBD patients were included: 109 treated with IFX and 91 with ADA. Data were collected using the computerized medical records from the DIRAYA program of the Servicio Andaluz de Salud. Response—defined as improvement—and remission—defined as the disappearance of symptoms and analytical/endoscopic signs—were assessed using activity indices (partial Mayo, Harvey–Bradshaw) in all patients. Anti-TNF drug levels were also determined, as well as the presence or absence of anti-IFX and anti-ADA antibodies. The reporting of this study conforms to the Strengthening the Reporting of Observational Studies in Epidemiology statement. Results: The HLA-DQA1⋆05 haplotype was present in 70 (35%) patients, including 39 (36%) treated with IFX and 31 (34%) with ADA. The risk of withdrawal, intensification, as well as antibody development, was higher in patients carrying the allele and on treatment with IFX or ADA. Conclusion: In our study, we demonstrated that there is an increased risk of immunogenicity in patients carrying the HLA-DQA1⋆05 genotype, which would support the idea of screening for this genetic variant before starting anti-TNF therapy, as its prevalence is high in the general population and increases the risk of treatment discontinuation due to loss of response.
A machine learning-based nomogram model for predicting the recurrence of cystitis glandularis
Authors: Liu Xuhao , Wang Yuhang , Wang Yinzhao , Dao Pinghong , Zhou Tailai , Zhu Wenhao , Huang Chuyang , Li Yong , Yan Yuzhong , Chen Minfeng 
Published: October 2024

Background: Cystitis glandularis is a chronic inflammatory disease of the urinary system characterized by high recurrence rates, the reasons for which are still unknown. Objectives: This study aims to identify potential factors contributing to recurrence and propose a simple and feasible prognostic model through nomogram construction. Design: Patients with confirmed recurrence based on outpatient visits or readmissions were included in this study, which was subsequently divided into training and validation cohorts. Methods: Machine learning techniques were utilized to screen for the most important predictors, and these were then employed to construct the nomogram. The reliability of the nomogram was assessed through receiver operating characteristic curve analysis, decision curve analysis, and calibration curves. Results: A total of 252 patients met the screening criteria and were enrolled in this study. Over the 12-month follow-up period, the relapse rate was found to be 57.14% ( n = 144). The five final predictors identified through machine learning were urinary infections, urinary calculi, eosinophil count, lymphocyte count, and serum magnesium. The area under curve values for all three time points assessing recurrence exceeded 0.75. Furthermore, both calibration curves and decision curve analyses indicated good performance of the nomogram. Conclusion: We have developed a reliable machine learning-based nomogram for predicting recurrence in cystitis glandularis
Engagement communautaire et prise en compte de la détresse psychologique, de la peur et de la stigmatisation dans la surveillance et la gestion des épidémies de la maladie à virus Ebola dans l’approche « Une seule santé » en République démocratique du Congo
Authors: Mwamba Dieudonné Kazadi , Zarowsky Christina , Manianga Célé Depaul , Kapanga Serge , Moullec Grégory 
Published: October 2024

Introduction et objectif : Une réponse efficace aux crises sanitaires telle la maladie à virus Ebola (MVE) nécessite l’engagement des communautés. Cette étude explore les enjeux psychosociaux influant sur la réponse des communautés congolaises aux épidémies de MVE, et comment la détresse et la résilience communautaire s’intègrent dans l’approche « Une seule santé » selon les perceptions des communautés. Méthodes : Cette étude de cas qualitative inclut des entretiens individuels ( n = 36) avec des informateurs clés et trois groupes de discussion avec des participants ( n = 28) issus de diverses associations locales, Cette étude de cas qualitative menée au Nord-Kivu inclut. Le cadre MATCH de l’engagement communautaire, adapté, structure l’analyse thématique. Résultats : Les participants ont tous reconnu le vécu douloureux – la peur, le rejet, la stigmatisation – des communautés et des professionnels de santé, et le rôle crucial des communautés dans la réponse aux épidémies. Ils ont souligné l’importance d’impliquer ces communautés dans l’élaboration et la mise en œuvre des stratégies pour éviter l’« Ebola business ». Les perceptions face à la maladie des différentes catégories de participants sont influencées par des croyances, les rôles sociaux et des considérations religieuses. Concernant l’approche « Une seule santé », les participants ont reconnu la nécessité d’impliquer toutes les couches sociales de la communauté. Conclusion : Un modèle innovant de gestion des épidémies et urgences de santé publique intègre les essentiels de l’engagement communautaire dont la détresse psychologique.
Identification of a central network hub of key prognostic genes based on correlation between transcriptomics and survival in patients with metastatic solid tumors
Authors: Lazar Vladimir , Raymond Eric , Magidi Shai , Bresson Catherine , Wunder Fanny , Berindan-Neagoe Ioana , Tijeras-Rabaland Annemilaï , Raynaud Jacques , Onn Amir , Ducreux Michel , Batist Gerald , Lassen Ulrik , Cilius Nielsen Fin , Schilsky Richard L. , Rubin Eitan , Kurzrock Razelle 
Published: October 2024

Background:Dysregulated pathways in cancer may be hub addicted. Identifying these dysregulated networks for targeting might lead to novel therapeutic options.Objective:Considering the hypothesis that central hubs are associated with increased lethality, identifying key hub targets within central networks could lead to the development of novel drugs with improved efficacy in advanced metastatic solid tumors.Design:Exploring transcriptomic data (22,000 gene products) from the WINTHER trial ( N = 101 patients with various metastatic cancers), in which both tumor and normal organ-matched tissue were available.Methods:A retrospective in silico analysis of all genes in the transcriptome was conducted to identify genes different in expression between tumor and normal tissues (paired t-test) and to determine their association with survival outcomes using survival analysis (Cox proportional hazard regression algorithm). Based on the biological relevance of the identified genes, hub targets of interest within central networks were then pinpointed. Patients were grouped based on the expression level of these genes ( K-mean clustering), and the association of these groups with survival was examined (Cox proportional hazard regression algorithm, Forest plot, and Kaplan–Meier plot).Results:We identified four key central hub genes— PLOD3, ARHGAP11A, RNF216, and CDCA8, for which high expression in tumor tissue compared to analogous normal tissue had the most significant correlation with worse outcomes. The correlation was independent of tumor or treatment type. The combination of the four genes showed the highest significance and correlation with the poorer outcome: overall survival (hazard ratio (95% confidence interval (CI)) = 10.5 (3.43–31.9) p = 9.12E−07 log-rank test in a Cox proportional hazard regression model). Findings were validated in independent cohorts.Conclusion:The expression of PLOD3, ARHGAP11A, RNF216, and CDCA8 constitute, when combined, a prognostic tool, agnostic of tumor type and previous treatments. These genes represent potential targets for intercepting central hub networks in various cancers, offering avenues for novel therapeutic interventions.