bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amino Acid Degrading Enzymes and their Application in Cancer Therapy
Authors: Pokrovsky Vadim S. , Chepikova Olga E. , Davydov Denis Zh. , Zamyatnin Jr Andrey A. , Lukashev Alexander N. , Lukasheva Elena V. 
Published: October 2017

Background:Amino acids are essential components in various biochemical pathways. The deprivation of certain amino acids is an antimetabolite strategy for the treatment of amino acid-dependent cancers which exploits the compromised metabolism of malignant cells. Several studies have focused on the development and preclinical and clinical evaluation of amino acid degrading enzymes, namely L-asparaginase, L-methionine γ-lyase, L-arginine deiminase, L-lysine α-oxidase. Further research into cancer cell metabolism may therefore define possible targets for controlling tumor growth.Objective:The purpose of this review was to summarize recent progress in the relationship between amino acids metabolism and cancer therapy, with a particular focus on Lasparagine, L-methionine, L-arginine and L-lysine degrading enzymes and their formulations, which have been successfully used in the treatment of several types of cancer.Methods:We carried out a structured search among literature regarding to amino acid degrading enzymes. The main aspects of search were in vitro and in vivo studies, clinical trials concerning application of these enzymes in oncology.Results:Most published research are on the subject of L-asparaginase properties and it’s use for cancer treatment. L-arginine deiminase has shown promising results in a phase II trial in advanced melanoma and hepatocellular carcinoma. Other enzymes, in particular Lmethionine γ-lyase and L-lysine α-oxidase, were effective in vitro and in vivo.Conclusion:The findings of this review revealed that therapy based on amino acid depletion may have the potential application for cancer treatment but further clinical investigations are required to provide the efficacy and safety of these agents.
Gut Microbiota as a Therapeutic Target for Metabolic Disorders
Authors: Okubo Hirofumi , Nakatsu Yusuke , Kushiyama Akifumi , Yamamotoya Takeshi , Matsunaga Yasuka , Inoue Masa-ki , Fujishiro Midori , Sakoda Hideaki , Ohno Haruya , Yoneda Masayasu , Ono Hiraku , Asano Tomoichiro 
Published: October 2017

Background:
Gut microbiota play a vital role not only in the digestion and absorption of
nutrients, but also in homeostatic maintenance of host immunity, metabolism and the gut barrier. Recent
evidence suggests that gut microbiota alterations contribute to the pathogenesis of metabolic disorders.

Objective and Method:

In this review, we discuss the association between the gut microbiota and
metabolic disorders, such as obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease, and
the contribution of relevant modulating interventions, focusing on recent human studies.

Results:
Several studies have identified potential causal associations between gut microbiota and
metabolic disorders, as well as the underlying mechanisms. The effects of modulating interventions,
such as prebiotics, probiotics, fecal microbiota transplantation, and other new treatment possibilities on
these metabolic disorders have also been reported.

Conclusion:
A growing body of evidence highlights the role of gut microbiota in the development of
dysbiosis, which in turn influences host metabolism and disease phenotypes. Further studies are required
to elucidate the precise mechanisms by which gut microbiota-derived mediators induce metabolic
disorders and modulating interventions exert their beneficial effects in humans. The gut microbiota
represents a novel potential therapeutic target for a range of metabolic disorders.
The effectiveness of principal’s competencies implementation at SMAN 3 and Internasional Budi Mulia Dua Yogyakarta
Authors: Phannalath Vikate , Prasojo Lantip Diat 
Published: October 2017

This study aimed to evaluate the effectiveness of principal’s competencies implementation at SMA Negeri 3 Yogyakarta and SMA Internasional Budi Mulia Dua Yogyakarta, Indonesia. The research was an evaluation research using the discrepancy model of evaluation. The respondents were vice principals, teachers, as well as administrative officers. The data was collected through the questionnaires, the results of the study showed that the effectiveness of the principal’s competencies implementation at SMA Negeri 3 Yogyakarta is: personality competencies 78.84% effective, managerial competencies 82.69% effective, entrepreneurship competencies 78.84% effective, supervision competencies 84.61% effective, and social competencies 86.53% effective, while in the SMA Internasional Budi Mulia Dua was: personality competencies 100% effective, managerial competencies 100% effective, entrepreneurship competencies 100% effective, supervision competencies 96% effective, and social competencies 100% effective. The effectiveness of the principal’s competencies implementation of SMA Internasional Budi Mulia Dua Yogyakarta was better compared to SMA Negeri 3 Yogyakarta.Keywords: the effectiveness of personality competencies, managerial competencies, entrepreneurship competencies, supervision competencies, social competencies
The Lived Experience of “Being Evaluated” for Organ Donation
Authors: Hanson Camilla S. , Ralph Angelique F. , Manera Karine E. , Gill John S. , Kanellis John , Wong Germaine , Craig Jonathan C. , Chapman Jeremy R. , Tong Allison 
Published: October 2017

Background and objectives
Comprehensive evaluations are required to safeguard voluntarism and minimize harm to living kidney donors. This process is lengthy, invasive, and emotionally challenging, with up to one fifth of potential donors opting out. We aimed to describe donors’ experiences of the evaluation process.

Design, setting, participants, & measurements
We conducted 14 focus groups involving 123 kidney donors who completed donation from three transplant centers (Australia and Canada). Transcripts were analyzed thematically.

Results
We identified six themes reflecting donors’ experiences of evaluation. The themes that related to perseverance included emotional investment (prioritizing the recipient’s health, desperation for a normal life, protecting eligibility, shame of disappointing others, and overcoming opposition), undeterred by low risks (medical confidence and protection, worthwhile gamble, inherent invincibility, and normalizing risks), and mental preparation (avoiding regret, resolving decisional ambivalence, and managing expectations of recovery). The challenges included underlying fears for health (processing alarming information, unsettling uncertainty, and preoperative panic), system shortfalls (self-advocacy in driving the process, stressful urgency, inconsistent framing of safety, unnerving bodily scrutiny, questioning risk information, and draining finances); and lifestyle interference (living in limbo, onerous lifestyle disruption, and valuing flexibility).

Conclusions
Previous donors described an emotional investment in donating and determination to protect their eligibility, despite having concerns for their health, financial and lifestyle disruption, and opposition from their family or community. Our findings suggest the need to prepare donors for surgery and recovery, minimize anxiety and lifestyle burdens, ensure that donors feel comfortable expressing their fears and concerns, reduce unnecessary delays, and make explicit the responsibilities of donors in their assessment process.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_10_16_CJASNPodcast_17_11_.mp3
PHARMACISTS’ DISTRIBUTION IN NIGERIA; IMPLICATION IN THE PROVISION OF SAFE MEDICINES AND PHARMACEUTICAL CARE
Authors: Olukemi Oseni, Yejide , Oseni Yejide Olukemi 
Published: October 2017

Objective: The aim of the study was to appraise the distribution of pharmacists in the six (6) zones of Nigeria; determine the number of community pharmacies per population in each zone and in selected States; and assess the implication of pharmacists’ distribution in the provision of safe medicines and pharmaceutical care.Methods: Data analysis of pharmacists and community pharmacies in 6 zones of Nigeria was done using 2013 register and interviews conducted for pharmacists on the issue were analysed.Results: About fifty six percent (56.2%) of all registered pharmacists works in the community pharmacies. Distribution of community pharmacists shows Southwest (SW) 41.7%, Northcentral (NC) 20.6%, Southsouth (SS) 15.5%, Southeast (SE) 12.9%, Northwest (NW) 6.7% and Northeast (NE) 2.5%. In SW zone where pharmacists are highly concentrated, rural / urban distribution of community pharmacies revealed urban 89.9% and rural 10.1%, and a community pharmacy serviced 36,836 of the population. Inequitable distribution is due to low turn-out of graduate pharmacists, dearth of pharmacists abroad, poor remuneration, poor political will to employ pharmacists at the PHC level and poor amenities in the rural areas. This has led to irrational use of medicines, non-professionals in practice, chaotic drug distribution system, poor access to safe medicines and negative effects on health indicators.Conclusion: Improvement in country economy, increase number of faculties of pharmacy and improved facilities in the existing ones to increase turn-out of graduate pharmacists coupled with incentives for establishment of rural community pharmacy will increase access to safe medicines and care in Nigeria.
Effect of flapless osteoperforation-assisted tooth movement on atrophic alveolar ridge: Histomorphometric and gene-enrichment analysis
Authors: Lee Ji-Won , Cha Jung-Yul , Park Ki-Ho , Kang Yoon-Goo , Kim Su-Jung 
Published: October 2017

ABSTRACT

Objective:
To investigate the effect of flapless osteoperforation on the tissue response of the atrophic alveolar ridge affected by orthodontic tooth movement (OTM).

Materials and Methods:
An atrophic alveolar ridge model was established in the mandibular quadrants of eight beagle dogs. As a split-mouth design, the quadrants were randomly divided into group C (OTM only) and group OP (OTM with flapless osteoperforation). The rate of OTM for 10 weeks was compared between groups, and micro-CT-based histomorphometric analysis and RNA-sequencing-based gene-enrichment analysis were performed targeting the atrophic ridge.

Results:
Group OP displayed more rapid tooth movement with lower bone mineral density and higher trabecular fraction in the atrophic ridge than did group C, showing no intergroup difference of total ridge volume. As contributing biological functional pathways in group OP, the genes related to osteoclast differentiation and TNF signaling pathway were up-regulated and those associated with Wnt signaling pathway and AMPK signaling pathway were down-regulated.

Conclusions:
Flapless osteoperforation facilitated the rate of OTM toward the atrophic ridge, maintaining low bone density, whereas it did not increase the volume of the atrophic ridge.
Baixa escolaridade e doenças mentais em idosos: possíveis correlações
Authors: BIASOLI Tiago Rodrigo , MORETTO Maria Clara , GUARIENTO Maria Elena 
Published: October 2017

ObjetivoDescrever amostra de 334 idosos atendidos em ambulatórios do Hospital de Clínicas da Universidade Estadual de Campinas quanto ao perfil sociodemográfico e clínico- -psicológico e avaliar a relação entre baixa escolaridade e as variáveis clínicas. MétodosEsta pesquisa transversal com foco descritivo foi realizada com os dados digitais dos prontuários dos pacientes com transtorno mental, seguidos nas áreas de Geriatria, Psiquiatria e Neurologia do Hospital de Clínicas da Universidade Estadual de Campinas. Avaliou-se gênero, faixa etária, estado conjugal, escolaridade, diagnóstico psiquiátrico através da Classificação Internacional de Doenças, comorbidades, número de consultas no ano anterior à pesquisa, tempo de tratamento e óbitos. Para comparar os grupos segundo níveis de escolaridade, utilizou-se o teste Qui-quadrado, com nível de significância de 5% (p<0,05). ResultadosVerificou-se que a amostra era composta predominantemente por mulheres (65,5%); por idosos na faixa etária entre 70-79 anos (41,3%); casados (56,6%); e com ensino fundamental incompleto (65,0%). Os transtornos mentais orgânicos estavam presentes em 56,9% da amostra, seguidos por 28,1% com transtornos de humor. A baixa escolaridade teve associação positiva com tempo de tratamento, número de consultas e presença de comorbidades. ConclusãoO conhecimento das características dessa população pode ajudar a compreender as interrelações entre envelhecimento e os sinais/sintomas dos transtornos mentais, visando o planejamento, o diagnóstico e o tratamento precoce e mais eficiente.
Reliability and Validity of the Hip Stability Isometric Test (HipSIT): A New Method to Assess Hip Posterolateral Muscle Strength
Authors: Almeida Gabriel Peixoto Leão , das Neves Rodrigues Helena Larissa , de Freitas Bruno Wesley , de Paula Lima Pedro Olavo 
Published: October 2017

Study Design Cross-sectional study. Background The Hip Stability Isometric Test (HipSIT) evaluates the strength of the hip posterolateral stabilizers in a position that favors greater activation of the gluteus maximus and gluteus medius and lower activation of the tensor fascia lata. Objectives To check the validity and reliability of the HipSIT and to evaluate the HipSIT in women with patellofemoral pain (PFP). Methods The HipSIT was evaluated with a handheld dynamometer. During testing, the participants were sidelying, with their legs positioned at 45° of hip flexion and 90° of knee flexion. Participants were instructed to raise the knee of the upper leg while keeping the upper and lower heels in contact. To establish reliability and validity, 49 women were tested with the HipSIT by 2 different evaluators on day 1, and then again 7 days later. The strength of the hip extensors, abductors, and external rotators was also evaluated. Twenty women with unilateral PFP were also evaluated. Results The HipSIT has excellent intrarater and interrater reliability. The standard error of measurement was 0.01 kgf/kg, and the minimal detectable change was 0.036 kgf/kg. The HipSIT showed good validity in isolated hip abduction, external rotation, and extension (P<.01). Women with PFP showed a 10% deficit in the HipSIT results for the symptomatic limb (P = .01). Conclusion The HipSIT showed excellent interrater and intrarater reliability, moderate to good validity in women, and was able to identify strength deficits in women with PFP. J Orthop Sports Phys Ther 2017;47(12):906–913. Epub 9 Oct 2017. doi:10.2519/jospt.2017.7274
Hip Abductor Muscle Volume and Strength Differences Between Women With Chronic Hip Joint Pain and Asymptomatic Controls
Authors: Mastenbrook Matthew J. , Commean Paul K. , Hillen Travis J. , Salsich Gretchen B. , Meyer Gretchen A. , Mueller Michael J. , Clohisy John C. , Harris-Hayes Marcie 
Published: October 2017

Study Design Secondary analysis, cross-sectional study. Background Chronic hip joint pain (CHJP) can lead to limitations in activity participation, but the musculoskeletal factors associated with the condition are relatively unknown. Understanding the factors associated with CHJP may help develop rehabilitation strategies to improve quality of life of individuals with long-term hip pain. Objectives To compare measures of hip abductor muscle volume and hip abductor muscle strength between women with CHJP and asymptomatic controls. Methods Thirty women, 15 with CHJP and 15 matched asymptomatic controls (age range, 18–40 years), participated in this study. Magnetic resonance imaging was used to determine the volume of the primary hip abductor muscles, consisting of the gluteus medius, gluteus minimus, a small portion of the gluteus maximus, and the tensor fascia latae, within a defined region of interest. Break tests were performed using a handheld dynamometer to assess hip abductor strength. During the strength test, the participant was positioned in sidelying with the involved hip in 15° of abduction. Independent-samples t tests were used to compare muscle volume and strength values between those with CHJP and asymptomatic controls. Results Compared to asymptomatic controls, women with CHJP demonstrated significantly increased gluteal muscle volume (228 ± 40 cm3 versus 199 ± 29 cm3, P = .032), but decreased hip abductor strength (74.6 ± 16.8 Nm versus 93.6 ± 20.2 Nm, P = .009). There were no significant differences in tensor fascia lata muscle volume between the 2 groups (P = .640). Conclusion Women with CHJP appear to have larger gluteal muscle volume, but decreased hip abductor strength, compared to asymptomatic controls. J Orthop Sports Phys Ther 2017;47(12):923–930. Epub 9 Oct 2017. doi:10.2519/jospt.2017.7380
Peripheral Artery Disease: What You Need to Know
Authors: Walsworth Matthew K. , de Bie Rob , Figoni Stephen F. , O'Connell Jessica B. 
Published: October 2017

Synopsis Claudication from peripheral artery disease (PAD) may mimic or coexist with musculoskeletal conditions and represents an important diagnostic consideration in patients over 50 years of age. Physical therapists are optimally positioned to recognize this condition by incorporating a vascular history and physical examination in appropriately selected patients. Recognition of PAD is important both from the standpoint of addressing the ischemic risk to the limb and because PAD is associated with high cerebrovascular and cardiovascular risk. Therefore, multidisciplinary management of patients with PAD is essential. Extensive evidence supports treatment of PAD-related claudication with supervised exercise, and physical therapists are well positioned to play an important role in this treatment. J Orthop Sports Phys Ther 2017;47(12):957–964. Epub 9 Oct 2017. doi:10.2519/jospt.2017.7442
Pengaruh Penstabil Terhadap Karakteristik Fisikokimia Cookies
Authors: Ferdiansyah M Khoiron 
Published: October 2017

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan penstabil terhadap karakteristik fisikokimia cookies. Percobaan menggunakan rancangan faktorial RAL yang tersusun atas dua faktor, yaitu jenis dan konsentrasi penstabil. Penambahan penstabil CMC dan gum arab mempunyai pengaruh terhadap karakteristik fisikokimia produk cookies, khususnya kadar air dan nilai tekstur. Semakin tinggi konsentrasi penstabil maka kadar air cookies cenderung meningkat dan nilai tekstur menunjukkan tren menurun. Penambahan penstabil tidak mempunyai pengaruh yang nyata terhadap tingkat kecerahan (nilai L) cookies. Penambahan penstabil CMC menghasilkan cookies dengan nilai tekstur yang lebih tinggi dibandingkan dengan penstabil gum arab Kata kunci: penstabil, cookies, karakteristik, fisikokimia
Produksi Bersih Pada Industri Pangan Berbasis Perikanan
Authors: Dwi Ujianti Rizky Muliani 
Published: October 2017

Kerusakan lingkungan yang terjadi di Indonesia saat ini semakin besar. Limbah buangan oleh adanya kegiatan domestik dan kegiatan industri menjadi semakin banyak. Strategi dalam proses pengurangan limbah ini tidak bisa hanya dilakukan dengan menghilangkan dampak yang sudah terlanjur terjadi. Proses pencegahan sangat bisa dilakukan khususnya di kawasan industri yakni dengan Produksi bersih. Tulisan ini memberikan informasi mengenai proses produksi bersih pada industri perikanan. Metode yang dilakukan adalah dengan survey dan studi literatur mengenai produksi bersih pada industri pangan berbasis perikanan. Tulisan ini diharapkan bisa memberikan pengetahuan pada pembaca dan gambaran untuk pelaku industri perikanan agar bisa mengaplikasikan konsep produksi bersih ini pada industrinya. Proses produksi bersih yang bisa dilakukan dengan cara penghematan bahan baku, efisiensi energi dan akhirnya akan menghasilkan minimalisasi limbah yang bermanfaat bahkan digunakan kembali.
PENGEMBANGAN BAHAN AJAR MATEMATIKA SMA BERBENTUK TABLOID BERBANTUAN SOFTWARE WOLFRAM MATHEMATICA DENGAN PENDEKATAN KONTEKSTUAL PADA MATERI INTEGRAL
Authors: Shodiqin Ali , Zuhri Muhammad Saifuddin 
Published: October 2017

Penelitian dilatar belakangi hasil observasi yaitu kesulitan siswa dalam mengaitkan materi dengan dunia nyata. Peneliti berinisiatif melakukan inovasi pembelajaran yaitu mengembangkan bahan ajar matematika SMA berbentuk tabloid berbantuan Wolfram Mathematica dengan pendekatan kontekstual materi integral. Penelitian bertujuan memperoleh tabloid layak digunakan dan mengetahui keefektifan penggunaan tabloid di SMA N 1 Gubug. Jenis penelitian Research and Development dengan 4-D. Penelitian didapat: tabloid telah divalidasi dan hasil uji-t, yakni thitung = 2,728825, taraf signifikan 5%, ttabel = 1,67, karena thitung> ttabel, maka Ho ditolak, disimpulkan penggunaan tabloid lebih efektif untuk meningkatkan hasil belajar dalam proses pembelajaran. Hal ini ditunjukkan dengan proses dan hasil belajar siswa, yaitu keaktifan dan antusias siswa selama proses pembelajaran dan hasil belajar kelas eksperimen dengan ranah kognitif nilai rata-rata sebesar 83,128, data ranah afektif 78,92%, data ranah psikomotorik sebesar 80,50%, serta hasil belajar kelas kontrol ranah kognitif nilai rata-rata sebesar 77,128, data ranah afektif 77,48%, data ranah psikomotorik sebesar 75,54%.
Sistem Informasi Penampil Pengumuman Fakultas Teknik Universitas Diponegoro
Authors: Hernawan Fajar Yogi 
Published: October 2017

Abstract - Engineering Faculty is the biggest faculty with the highest number of departements and students in the Diponegoro University. The idea made SIPP (System Information Viewer Announcements Faculty of Engineering, University of Diponegoro) appears is to help disseminate information and stories of pride born from Engineering Faculty to become the impetus and motivation for more achievement.SIPP maked with 5(five) stages: requirement, analysis, design, implementation, testing. SIPP is built using the programming language PHP, HTML, CSS, Bootstrap, Javascript, and MySQL database. SIPP is expected to convey information and the pride stories of the Engineering Faculty in the multimedia. The output of the SIPP is the information shown via LCD TV screen ratio of 16: 9 which blend of images, video and running text. SIPP expected to be implemented in the lobby Engineering Faculty dean and in every department in it. Users SIPP is divided into 2 (two) they are admin faculty as the main admin and admin department as sub-admin. SIPP tested with 2 (two) test that is functionality testing by black box and performance testing with performance-analyzer application. With the implementation of SIPP environment Faculty of Engineering will be an additional alternative for the community Faculty of Engineering to obtain information.Keywords - Information, SIPP, multimedia, Engineering Faculty. Intisari – Fakultas Teknik adalah fakultas dengan jumlah jurusan dan mahasiswa terbanyak di Universitas Diponegoro. Gagasan dibuatnya SIPP (Sistem Informasi Penampil Pengumuman Fakultas Teknik Universitas Diponegoro) muncul adalah untuk membantu menyebarkan informasi dan cerita kebanggaan dari Fakultas Teknik yang menjadi dorongan dan motivasi untuk lebih berprestasi. SIPP dibuat dengan 5(lima) tahap : rencana kebutuhan, analisis kebutuhan, perancangan desain, perancangan sistem, dan pengujian. SIPP dibangun menggunakan bahasa pemrograman PHP, HTML, CSS, Bootstrap, Javascript, dan basisdata MySQL. SIPP diharapkan dapat menyampaikan informasi dan cerita kebanggaan dari Fakultas Teknik dalam bentuk multimedia. Keluaran dari SIPP ditampilkan melalui LCD TV rasio 16 : 9 yang merupakan perpaduan antara gambar, video, dan teks berjalan. SIPP diharapkan dapat dipasang di lobi dekanat Fakultas Teknik dan di setiap jurusan didalamnya. Pengguna SIPP dibagi menjadi 2(dua) yaitu admin fakultas sebagai admin utama dan admin jurusan sebagai sub-admin. SIPP diuji dengan 2(dua) pengujian yaitu uji fungsionalitas dengan black box dan uji performansi dengan aplikasi perfomnce-analyzer. Dengan penerapan SIPP akan menjadi alternatif untuk warga Fakultas Teknik mendapatkan informasi.Kata kunci – informasi, SIPP, multimedia, fakultas teknik.