bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Red Cell Surface Antigens During Erythropoiesis
Authors: Daniels Geoff , Green Carole 
Published: September 2024

Background and Objectives:We have analysed the appearance and disappearance of cell surface markers during crythropoiesis, in vitro.Materials and Methods:CD34+ haemopoietic progenitor cells were isolated from umbilical cord blood and cultured by three different methods, all in the presence of erythropoietin. The methods included two one‐stage techniques, one serum‐free, the other with serum present, and one scrum‐present two‐stage method.Results:The appearance of cell surface markers on the differentiating erythroid cells varied slightly from sample to sample, but differed more substantially between techniques, with the cells differentiating more rapidly in the culture media containing serum. The order of appearance of the markers, which was constant in the three methods, was as follows: glycophorin C. Kell, Rh‐associated glycoprotein. glycophorin A, band 3. Rh proteins, and glycophorin B.Conclusion:Cell surface antigens can be used as markers for mapping the progress of erythroid differentiation during erythropoiesis.
Transmission of Parasites and Bacteria by Blood Components
Authors: Dodd Roger Y. 
Published: September 2024

Background and Objectives:Although most attention has been paid to viral infections as a complication of transfusion, some parasitic infections are readily transmissible and generate a heavy burden of disease, particularly in the developing world. Additionally, bacterial infection as a result of transfusion is the most frequent serious outcome of transfusion in the developed world.Materials and Methods:Review of current literature and ongoing research studies.Results:Malaria and Chagas' disease continue to be a serious problem in endemic areas, but are also of concern as a result of their introduction into other regions. Means to control or detect bacterial contamination, particularly of platelet concentrates, are needed, but no simple, effective approach is available.Conclusion:Continued development and implementation of tests and of inactivation procedures will result in the eventual control of transfusion‐transmitted parasitic and bacterial discase.
Emerging Viruses in Blood Transfusion
Authors: Allain Jean‐Pierre 
Published: September 2024

Background and Objectives:The development of new technologies leads to the discovery of new viruses. For each of these new infectious agents relevance to transfusion needs to be assessed.Materials and Methods:The questions to be answered are transmissibility by transfusion, pathogenicity, prevalence in blood donors, persistence and the availability of screening assays.Results:Since 1995, four new viruses have been identified and for three of them extensive studies have been carried out. GBV‐C/HGV and TTV were both initially thought to be related to post‐transfusion hepatitis but neither were proven to be in any way related to hepatitis and are still in search of a disease. HHV‐8 is a major factor in the pathogenesis of Kaposi's sarcoma and other tumours related to immunodeficiency. HHV‐8 transmission by organ transplantation but not by transfusion has been demonstrated. SEN‐V has been claimed as a potential cause of non‐A‐E hepatitis but no data has been published.Conclusion:To date, none of the emerging viruses have been proven relevant to transfusion.
The Use of Telehealth for People With Disabilities: A Systematic Literature Review and Narrative Synthesis
Authors: Park Han Nah , Kang Gyeonga , Nam Hye Jin , Lee Sujin , Kim Bohye , Lee Haesun , Yoon Ju Young 
Published: October 2024

ABSTRACTAimsTo identify the use of telehealth for people with disabilities in community or primary care settings and to explore effective telehealth interventions for this group.DesignSystematic literature review and narrative synthesis.Data SourcesThe literature search was conducted in January 2024 using five electronic databases including PubMed, EMBASE, CINAHL, Cochrane library and PsycINFO.MethodsThe review followed the Tawfik's guideline and adhered to the Preferred Reporting Items for Systematic Review and Meta‐Analyses guidelines for reporting. Out of 7363 retrieved articles, 1871 duplicates were removed, 5389 were excluded after title and abstract review, and 4 were excluded due to unavailable full text. One additional article was obtained through citation and hand searching. Thirteen studies were quality assessed using the Mixed Methods Appraisal Tool. Quantitative data were narratively synthesised.ResultsThirteen quantitative studies were selected including three quasi‐experimental studies and ten randomised controlled trials. The types of telehealth included telemonitoring, computerised intervention, virtual reality, telephone care, mHealth tools, decision support tools, digital storytelling and technology‐assisted language interventions. The most common type of disability was intellectual disability, and the most common telehealth provider was the digital device itself. Most studies used surveys as the data collection method and the interventions were mostly conducted individually. Computer‐based telehealth interventions demonstrated significant improvement in attention, health knowledge and psychological well‐being. Telephone, virtual reality and tablet interventions also had positive impacts on body weight, motor coordination and pragmatic language skills. Telemonitoring was also beneficial.ConclusionsThis systematic review examined the current state and effectiveness of telehealth interventions for people with disabilities. However, few intervention studies were found, and some studies were of poor quality. Continued interest and efforts from the government and researchers are needed targeting people with disabilities.ImpactResults provide valuable insights for healthcare providers, policymakers and researchers. They raise awareness about the potential of telehealth to address healthcare disparities and improve access to care for people with disabilities.Patient or Public ContributionNo patient or public contribution: Systematic review.
Experiences and Understanding of Well‐Being in Lung Transplant Recipients in China: A Phenomenological Qualitative Study
Authors: Song Liqin , Liu Chunqin , Zhou Ying , Ju Chunrong , Luo Qing , Cheng Jing , Huang Danxia , Chen Huifang , Chen Jiani , Tan Wenying , Hu Xinyang , Liu Yimeng , Smith Graeme D. 
Published: September 2024

ABSTRACTAimTo explore lung transplant recipients' perceptions of well‐being when they are facing uncertain health outcomes, including identifying the factors to enhance well‐being.DesignA qualitative descriptive study.MethodsA purposive sample of 11 lung transplantation recipients who were hospitalised in the Department of Organ Transplantation of a tertiary university hospital was recruited in China. A descriptive qualitative study using thematic analysis of semistructured interviews. Themes were organised within a PERMA model. Colaizzi's qualitative analysis was used to analyse the data.ResultsFive major themes and 11 categories were generated: (1) mindset shift [optimism and hope and living in the moment]; (2) meaning in life [self‐care, priority change and value realisation]; (3) health benefits [improved health and behavioural changes]; (4) perceived support [support from family, the health care team and others]; (5) unmet support needs.ConclusionLung transplant recipients could perceive well‐being from five aspects that caused significantly favourable transformation across a variety of aspects in patients' lives. These findings may support nursing staff when caring for this patient group, making them aware of multifaceted nature of well‐being. They could offer insight into potential pathways for the development of nurse‐led tailored interventions, based on specific elements of PERMA model.ImpactThis work adds to a growing body of knowledge about well‐being amongst lung transplant patients. These findings may support nursing staff when caring for this patient group, making them aware of multifaceted nature of well‐being and illustrating factors that promote positive well‐being in this group, based on specific elements of PERMA model.Reporting MethodThis study followed the Consolidated Criteria for Reporting Qualitative Research checklist.Patient or Public ContributionTwo lung transplant recipients were involved in the early phases of this study. They helped in formulating the interview outline.
Gerotranscendence as a Life Perspective Among Nursing Home Residents: A Qualitative Study Into Positive Ageing While Dependent on 24/7 Care
Authors: Tip Merle , Braam Arjan , Van Der Vaart Wander 
Published: September 2024

ABSTRACTAimsTo examine whether and how older nursing home residents recognise characteristics of gerotranscendence, and to contribute to a critical and comprehensive view of gerotranscendence in this particular group.BackgroundGerotranscendence is a psychosocial, spiritual development theory within the field of positive ageing that represents: a shift in meta‐perspective, from a materialistic and rational vision to a cosmic and transcendent life perspective, followed by an increase in life satisfaction.DesignA qualitative study using a narrative hermeneutical approach.MethodsParticipants were 20 residents of a nursing home in the Netherlands, aged 77 to 105 (mean age: 90). The semi‐structured interviews, conducted in April 2023, were based on Tornstam's 10‐item Gerotranscendence Scale. Special attention was paid to the technique of interviewing these frail, older adults, some of them diagnosed with dementia.FindingsAll respondents recognised several characteristics of gerotranscendence, or signs of it emerged from the research data. There is a larger middle group with respondents who call themselves ‘down‐to‐earth’. They mainly recognise the relational characteristics. Another group appears to be more contemplative and shows more affinity with the abstract, cosmic characteristics. They have developed a gerotranscendent wisdom: there is insight, contextualism and relativism, peace of mind, room for life's paradoxes, a high degree of (self‐)acceptance and an ability to ‘let go’. The data show considerable heterogeneity in thoughts, perspectives and degrees of gerotranscendence.DiscussionRespondents found some questions difficult to answer, resulting in a critical assessment of how to understand the responses given. This puts pressure on data quality for this current study and for critical gerotranscendence research in general. Furthermore, interviewing older nursing home residents requires a custom setting and possibly a new interview methodology.Reporting MethodThis report adheres to the standards for reporting qualitative research (SRQR).Patient or Public ContributionNo patient or public contribution.
Exploring Nurses' Behavioural Intention to Adopt AI Technology: The Perspectives of Social Influence, Perceived Job Stress and Human–Machine Trust
Authors: Chen Chin‐Hung , Lee Wan‐I 
Published: September 2024

ABSTRACTAimThis study examines how social influence, human–machine trust and perceived job stress affect nurses' behavioural intentions towards AI‐assisted care technology adoption from a new perspective and framework. It also explores the interrelationships between different types of social influence and job stress dimensions to fill gaps in academic literature.DesignA quantitative cross‐sectional study.MethodsFive hospitals in Taiwan that had implemented AI solutions were selected using purposive sampling. The scales, adapted from relevant literature, were translated into Chinese and modified for context. Questionnaires were distributed to nurses via snowball sampling from May 15 to June 10, 2023. A total of 283 valid questionnaires were analysed using the partial least squares structural equation modelling method.ResultsConformity, obedience and human–machine trust were positively correlated with behavioural intention, while compliance was negatively correlated. Perceived job stress did not significantly affect behavioural intention. Compliance was positively associated with all three job stress dimensions: job uncertainty, technophobia and time pressure, while obedience was correlated with job uncertainty.ConclusionSocial influence and human–machine trust are critical factors in nurses' intentions to adopt AI technology. The lack of significant effects from perceived stress suggests that nurses' personal resources mitigate potential stress associated with AI implementation. The study reveals the complex dynamics regarding different types of social influence, human–machine trust and job stress in the context of AI adoption in healthcare.ImpactThis research extends beyond conventional technology acceptance models by incorporating perspectives on organisational internal stressors and AI‐related job stress. It offers insights into the coping mechanisms during the pre‐adaption AI process in nursing, highlighting the need for nuanced management approaches. The findings emphasise the importance of considering technological and psychosocial factors in successful AI implementation in healthcare settings.Patient or Public ContributionNo Patient or Public Contribution.
Risk factors associated with clinically relevant pericardial effusion after primary cardiac implantable electronic device implantation
Authors: Zhou Yangzhi , Haxha Saranda , Halili Andrim , Philbert Berit T. , Nielsen Olav W. , Sajadieh Ahmad , Koeber Lars , Gislason Gunnar H. , Torp‐Pedersen Christian , Bang Casper N. 
Published: October 2024

AbstractIntroductionPericardial effusion, a known complication to implantation of cardiac implantable electronic devices (CIED), may cause life‐threatening cardiac tamponade. Limited knowledge is available about risk factors for clinically relevant procedural pericardial effusion. The aim is to identify the patient‐ and procedure‐related risk factors associated with clinically relevant procedural pericardial effusion.MethodA nationwide observational cohort study based on data on 55 121 patients from the Danish Pacemaker Register between 2000 and 2018. We defined a clinically relevant procedural pericardial effusion related to the implantation if it occurred within 90 days after the primary CIED‐procedure. Prespecified risk factors were analysed by multivariable logistic regression models to estimate the association with pericardial effusion.ResultsThere were 115 (0.21%) patients diagnosed with clinically relevant procedural pericardial effusion, with a median age of 75 years and 38.3% were females. Of these, 80.9% lead to a subsequent pericardiocentesis procedure. In adjusted logistic regression analysis, an increased risk of clinically relevant pericardial effusion was associated with female sex (OR:1.49 [95%CI: 1.03–2.16]), heart failure (OR:1.54 [95%CI: 1.06–2.23]), previous cardiac surgery (OR:1.63 [95%CI: 1.05–2.55]), CRT‐device (OR:2.05 [95%CI: 1.23–3.41]), tertiary‐centres (OR:1.8 [95%CI: 1.18–2.73]), increased procedural volume per year (>1000) (OR:1.85 [95%CI: 1.03–3.30]), indication of device‐implantation (atrioventricular block) (OR:2.37 [95CI: 1.45–3.87]), and increasing number of leads implanted (two leads (OR:2.39 [95%CI: 1.43–4.00]), three leads (OR:4.77 [95%CI: 2.50–9.10])).ConclusionClinically relevant procedural pericardial effusion is a rare complication after CIED‐implantation in Denmark. This study reveals important patient‐ and procedure‐related risk factors associated with clinically relevant procedural pericardial effusion.
IGFBP7 regulates cell proliferation and migration through JAK/STAT pathway in gastric cancer and is regulated by DNA and RNA methylation
Authors: Mo Weilie , Deng Lijian , Cheng Yun , Ge Sen , Wang Jin 
Published: October 2024

AbstractNew biomarkers for early diagnosis of gastric cancer (GC), the second leading cause of cancer‐related death, are urgently needed. IGFBP7, known to play various roles in multiple tumours, is complexly regulated across diverse cancer types, as evidenced by our pancancer analysis. Bioinformatics analysis revealed that IGFBP7 expression was related to patient prognosis, tumour clinicopathological characteristics, tumour stemness, microsatellite instability and immune cell infiltration, as well as the expression of oncogenes and immune checkpoints. GSEA links IGFBP7 to several cancer‐related pathways. IGFBP7 deficiency inhibited GC cell proliferation and migration in vitro. Furthermore, an in vivo nude mouse model revealed that IGFBP7 downregulation suppressed the tumorigenesis of GC cells. Western blotting analysis showed that the JAK1/2‐specific inhibitor ruxolitinib could rescue alterations induced by IGFBP7 overexpression in GC cells. Additionally, our bioinformatics analysis and in vitro assays suggested that IGFBP7 is regulated by DNA methylation at the genetic level and that the RNA m6A demethylase FTO modulates it at the posttranscriptional level. This study emphasizes the clinical relevance of IGFBP7 in GC and its influence on cell proliferation and migration via the JAK/STAT signalling pathway. This study also highlights the regulation of IGFBP7 in GC by DNA and m6A RNA methylation.
A Cross‐Sectional Study of Risk Factors for Coronary Heart Disease in Secondary Prevention for Patients With the Disease in China
Authors: Shen Qianqian , Wu Yiyuan , Zhou Ying , Yang Na , Yu Juping , Ouyang Xinping , He Pingping 
Published: September 2024

ABSTRACTAimsTo explore risk factors for Coronary Heart Disease (CHD) in secondary prevention for patients with the disease in China.DesignCross‐sectional study.MethodsA two‐stage sampling method was used (stratified sampling and systematic sampling). Patients who met WHO diagnostic criteria for CHD, had the capacity to give informed consent and volunteered to participate were recruited from five districts in Hengyang city, Hunan province, China. Six instruments were used: A general socio‐demographic questionnaire, Coronary Heart Disease Self‐Management Scale, International Physical Activity Questionnaires, Chinese Eight‐Item Morisky Medication Adherence Scale, Zung's Self‐Rating Anxiety Scale and Sexual Health Questionnaires. Participants completed the questionnaires in person or via telephone. Single‐factor correlation analysis, Pearson correlation analysis and multiple linear regression analysis were carried out.ResultsA total of 373 patients were recruited with a mean age of 66.25 years (standard deviation = 9.98). The mean score was 57.00 (14.23) for self‐management, 5.41 (1.82) for medication adherence, 53.61 (9.26) for anxiety, 8.66 (3.18) for sexual knowledge and 22.20 (9.68) for the need for sexual health education. The median was 1563.90 MET‐min/day for total energy consumption of physical activity. Self‐management, physical activity, medication adherence, anxiety and sexual health were significantly correlated with a range of demographic variables (age, gender, marital status, occupation, education levels, types of medical insurance, personal monthly income, living arrangements) and illness‐related variables (illness duration, number of hospital admissions, type of therapy, number of other chronic diseases, cardiac function grading and BMI).ConclusionThis research has showed the risk factors related to self‐management skills, medication adherence, anxiety, physical activity, sexual knowledge and the need for sexual health education in secondary prevention for patients with CHD. Health professionals play an important role in helping patients reduce risk factors for CHD to minimise its reoccurrence and mortality.Relevance to Clinical PracticeBoth hospital‐based and community‐based health professionals, especially nurses, have an important role to play in developing and implementing health promotion interventions to help patients with CHD reduce risk factors for the disease and thus reduce mortality.Patient or Public ContributionNo patient contribution. Community nursing staff contributed to the design of the general socio‐demographic questionnaire for this study.Reporting MethodThe STROBE checklist was used to ensure comprehensive reporting (Appendix S1).
Comparative Diagnostic Accuracy of Nursing Delirium Screening Scale Versus Confusion Assessment Method for Postoperative Delirium: A Systematic Review and Meta‐Analysis
Authors: Lin Chia‐Jou , Fick Donna Marie , Traynor Victoria , Chen Yi‐Chen , Hsiang Hui‐Fen , Chiu Hsiao‐Yean 
Published: September 2024

ABSTRACTAimsTo synthesise the evidence on and to compare the diagnostic accuracy of the Nu‐DESC and CAM in detecting postoperative delirium among hospitalised patients.DesignSystematic review and diagnostic meta‐analysis.Data SourcesThe PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, ProQuest Dissertations and Theses A&I, and PsycINFO databases were systematically searched from their inception to February 10, 2023.ResultsIn total, 10 (n = 1950) and seven (n = 830) reports were included for the Nu‐DESC and CAM, respectively. For Nu‐DESC and CAM, the pooled sensitivities were 0.69 and 0.65, respectively, while the summary specificities were 0.99 for Nu‐DESC and 0.92 for CAM. The pooled specificity differed significantly between the two tools (p < 0.001), despite comparable pooled sensitivities. The duration of stay in the intensive care unit significantly moderated the summary specificity of Nu‐DESC (B = −0.0003, p = 0.009). Regarding CAM, the percentage of female participants showed a positive correlation with its pooled sensitivity (B = 0.005, p = 0.02). Furthermore, studies where clinical specialists served as assessors demonstrated a higher summary sensitivity than those assessed by nurses (0.87 vs. 0.25, p = 0.01).ConclusionThe sensitivities of the Nu‐DESC and CAM for detecting postoperative delirium did not achieve optimal levels. Therefore, developing more accurate tools to detect postoperative delirium by integrating features from related risk factors or incorporating technology‐based algorithms to enhance the screening capability is warranted.Reporting MethodThe study has adhered to PRISMA‐DTA guideline.Patient or Public ContributionNo patient or public contribution.Trial RegistrationThe study protocol has been registered on PROSPERO (CRD42023398961)
Amazon deforestation and CO2 emissions: A macroeconomic approach using the GVAR
Authors: Attílio Luccas Assis 
Published: October 2024

AbstractWe analyzed the relationship between economic variables, Amazon deforestation, and CO2 emissions in Brazil. We used a macroeconomic approach of a system of open economies (global vector autoregressive [GVAR]). We constructed the international economy using 34 countries, representing 77% of the world GDP and 80% of world CO2 emissions. GVAR allows us to simulate the world economy, capture spillover effects, incorporate the externality of gas emissions, treating Brazil as a small open economy, and including trade integration in the analysis. We found that domestic and external shocks affect Amazon deforestation and CO2 emissions; the principal external shock is the Chinese one, followed by the European and the US shocks. China, directly and indirectly, affects CO2 emissions and deforestation in Brazil through two channels (exchange rates and policy rates). The estimates showed that Brazilian currency and commodity prices are relevant for deforestation, while industrial production is for gas emissions. Other results are that (i) the Brazilian economy affects CO2 emissions in Latin America (and the principal influence of China is on Asia), and (ii) the Chinese shock loses importance when using bilateral trade in 1999–2001, when China was not a fundamental trade partner of Brazil. Alternative model configurations demonstrate that soybean prices and Argentina influence Brazilian carbon emissions and Amazon deforestation. Specifically, soybean prices emerge as a major driver of carbon emissions. These results suggest that geography and trade integration matter to understanding Amazon deforestation and CO2 emissions. Our estimates highlight the importance of government policies and international cooperation in curbing Amazon deforestation.