bluuebunny/crossref_metadata_2025_split huggingface dataset:
Δραστηριότητες στην εξ Αποστάσεως Εκπαίδευση για την ανάπτυξη γνωστικών δεξιοτήτων: Συμπεριφοριστική και Κονστρουκτιβιστική προσέγγιση
Authors: Κυριζοπούλου Σοφία Αντώνιος , Σπανακά Αδαμαντία , Λιοναράκης Αντώνης 
Published: September 2024

Το εκπαιδευτικό υλικό εξ αποστάσεως εκπαίδευσης με τις δραστηριότητες που περιέχει στοχεύει στην απόκτηση γνωστικών δεξιοτήτων, με τις οποίες ο/η εκπαιδευόμενος/-η θα ενισχύσει τη μάθηση και θα δημιουργήσει νέες δυνατότητες ευημερίας και επιτυχίας στο κοινωνικό περιβάλλον που ζει και εργάζεται. Ποια όμως είναι τα κριτήρια για την επιλογή τέτοιων δραστηριοτήτων μάθησης, ώστε να επιτευχθεί η ενίσχυση της δημιουργικότητας και της κριτικής σκέψης; Ο γνωστικός κονστρουκτιβισμός υποστηρίζει τη δημιουργία πολυποίκιλων, κατανοητών δραστηριοτήτων μάθησης, οι οποίες θα λαμβάνουν υπόψη τις πρότερες γνώσεις των εκπαιδευόμενων, και θα οικοδομούνται γύρω από μια κεντρική έννοια. Στον συμπεριφορισμό δίνεται μεγάλη αξία στην ίδια τη συμπεριφορά και την τροποποίησή της. Όλοι οι εκπαιδευόμενοι/-ες μπορούν να μάθουν, να αναπτύξουν δεξιότητες και να διαμορφώσουν σταδιακά την επιθυμητή συμπεριφορά μέσω της θετικής ενίσχυσης. Συνεπώς, μαθησιακές δραστηριότητες που έχουν σαφή στοχοθεσία, είναι προσεκτικά σχεδιασμένες και διατεταγμένες, παρέχοντας θετικά ερεθίσματα που δημιουργούν αντίδραση, ενισχύουν μια συγκεκριμένη συμπεριφορά μάθησης.
Η εξ αποστάσεως Εκπαίδευση Ενηλίκων ως ευκαιρία μάθησης για ευάλωτη κοινωνική ομάδα κακοποιημένων γυναικών (Μεθοδολογία Εκπαίδευσης Ενηλίκων)
Authors: ΠΛΑΓΙΣΟΥ ΟΛΓΑ , Τσιρίδη Αναστασία , Μελισσαράτος Γεράσιμος , Ραμουτσάκη Ιωάννα Α. 
Published: September 2024

Σκοπός της συγκεκριμένης εισήγησης είναι η ανάδειξη των δυνατοτήτων του ψηφιακού περιβάλλοντος της εξ αποστάσεως Εκπαίδευσης Ενηλίκων και η αξιοποίησή του στο πλαίσιο της εκπαίδευσης ευάλωτων κοινωνικών ομάδων και, ειδικότερα, κακοποιημένων γυναικών. Kύριο μέλημα του/της εκπαιδευτή/εκπαιδεύτριας ενηλίκων σ’ αυτή την εκπαιδευτική διαδικασία είναι η απόκτηση γνώσης και η ψυχολογική ενδυνάμωση των γυναικών αυτών, ώστε εκείνες να αντιμετωπίσουν τη ζωή με περισσότερη αισιοδοξία και αυτοπεποίθηση. Αξιοποιούνται κατεξοχήν ενεργητικές τεχνικές, που υποστηρίζονται από τη δυναμική της ομάδας, την Τέχνη και από δόκιμες πηγές. Από την περιγραφή αναδεικνύεται ότι το ψηφιακό περιβάλλον και οι κατάλληλοι εκπαιδευτικοί χειρισμοί του/της εκπαιδευτή/εκπαιδεύτριας μπορούν να οδηγήσουν τους εκάστοτε εκπαιδευομένους σε αναστοχασμό, ατομική ανάπτυξη, αυτο-επίγνωση και αυτο-βελτίωση.
Σχεδιάζοντας Ιστο-εξερευνήσεις για το μάθημα της Αγγλικής Γλώσσας στη Δευτεροβάθμια Εκπαίδευση
Authors: Καραγιάννη Ευαγγελία , Αλεξανδροπούλου Μαριάνθη 
Published: September 2024

Η παρούσα εισήγηση έχει στόχο να παρουσιάσει σύντομα το θεωρητικό πλαίσιο μιας δομημένης διερευνητικής δραστηριότητας στον Παγκόσμιο Ιστό (WebQuest ήιστο-εξερεύνηση) και να εστιάσει σε ένα παράδειγμα πρακτικής εφαρμογής. Αναλυτικότερα, παρουσιάζονται ο σχεδιασμός, οι στόχοι και τα στάδια μιας ιστο-εξερεύνησης, ιστότοποι αναζήτησης και υλοποίησης σχετικών δραστηριοτήτων και μια πρακτική εφαρμογή με στόχο την ανάπτυξη αντίστοιχων δραστηριοτήτων τόσο στη φυσική σχολική τάξη όσο και σε περιβάλλοντα που αξιοποιούνται στην εξ αποστάσεως σχολική εκπαίδευση, όπως η Webex (ομόχρονα), η e-class και η e-me (ετερόχρονα).
Hypercholesterolemia - non-pharmacological treatment, monotherapy or combination therapy. Review of the literature
Authors: Łowicka Weronika , Graca Magdalena , Szeliga Anna , Szostak Agata , Korta Karolina , Oluszczak Karolina , Szopińska Kinga , Dyląg Liliana , Śmigielska-Mikołajczyk Maria Janina , Wawszkowicz Konrad 
Published: September 2024

Introduction:
As the number of scientific studies on lipid metabolism disorders increases, awareness among the medical community and the general population about the impact of hypercholesterolemia on the risk of cardiovascular diseases is growing. Elevated cholesterol levels in the blood are a major factor in the development of atherosclerosis, thereby increasing the likelihood of sudden cardiovascular events such as heart attacks or strokes. Maintaining normal cholesterol levels in the blood requires effective collaboration between the doctor and the patient, combining optimal pharmacotherapy with effective non-pharmacological methods based on the introduction of a balanced diet and moderate, regular physical activity. Current guidelines, based on numerous scientific studies, provide a clear framework for lipid-lowering treatment, with statins being an integral part. In cases where monotherapy is ineffective, ezetimibe and monoclonal antibodies, among others, can be used. In our work, we will discuss the possibilities of both non-pharmacological therapy and pharmacotherapy.

Aim of the study:
The aim of this study is to review current knowledge on non-pharmacological and pharmacological therapy in hypercholesterolemia.

Material and method:
This article presents the current state of knowledge about non-pharmacological and pharmacological therapy in hypercholesterolemia. Publications reviewed using the PubMed platform contain recent report in field of lipid metabolism disorders. The search included the keywords: ‚Hypercholesterolemia’, ‚LDL-C’, ‚Statin’, ,Ezetimibe’, ,PCSK9 inhibitors’.
Comparison of Non-Surgical Methods for Treating Hemorrhoids
Authors: Miga-Orczykowska Nadia , Lemieszek Paulina , Sajkiewicz Ilona , Rudnicka Katarzyna 
Published: September 2024

Introduction and purpose
Hemorrhoidal disease is one of the most common proctological problems worldwide. The etiology of hemorrhoidal disease has not been fully explained. Authors note that lifestyle factors and dietary habits are primarily responsible for hemorrhoidal disease. These include: a low-fiber diet, constipation, a sedentary lifestyle, and suboptimal body position during defecation commonly observed in Western societies. Due to the high prevalence of the disease in the population and the associated decrease in quality of life, outpatient procedural treatments that are highly effective and allow for a quick return to normal activity are very popular among patients. The aim of this study is to discuss non-surgical methods of hemorrhoid treatment.
Material and methods
This paper was based on a review of materials available on PubMed, searched using the following keywords: “hemorrhoids”, “sclerotherapy”, “rubber band ligation”, „infrared coagulation”, „laser hemorrhoidoplasty”, „Doppler guides hemorrhoidal artery ligation”.

Results
In recent years, there has been a significant development in non-surgical techniques for treating hemorrhoids, which are widely used in patients with grade I-III hemorrhoids and can be performed in an outpatient setting or during short hospital stays with the use of regional anesthesia, such as: Sclerotherapy, rubber band ligation, Infrared coagulation, Laser hemorrhoidoplasty, Doppler Guides Hemorrhoidal Artery Ligation.
Conclusion
In conclusion, non-surgical methods for the treatment of hemorrhoids offer a range of effective alternatives to conventional surgery. The choice of treatment should be individualized, taking into account the severity of the hemorrhoidal disease, patient preferences, and the potential for complications.
Type 1 Diabetes: An In-Depth Review of Pathogenesis with a Focus on the Role of Physical Activity and Dietary Interventions
Authors: Konopka Agata , Smołka Weronika , Skrzypczyk Marcin , Smółka Leon 
Published: September 2024

Introduction:
Pompe disease is classified as a metabolic myopathy and is a glycogen storage disorder inherited in an autosomal recessive manner due to a mutation in the gene encoding the enzyme α-glucosidase. There are two main forms: infantile and late-onset. The disease progresses chronically, with clinical presentation characterized by progressive muscle weakness and varying degrees of respiratory insufficiency. Although incurable, causative treatment is available in the form of enzyme replacement therapy with alglucosidase alfa, a human recombinant α-glucosidase. Early diagnosis, primarily based on enzyme activity assessment, is crucial as timely treatment can extend and improve patients' quality of life.
Purpose of the work: This study aims to review and characterize the clinical and genetic aspects of Pompe disease.
Materials and methods: A comprehensive analysis of research papers available on PubMed, Google Scholar, Web of Science, Embase and Scopus was undertaken using the searchterms encompassing the following keywords: Pompe disease / lysosomal storage disease / myopathy / acid alpha-1,4-glucosidase / glycogen / newborn screening / enzyme replacement therapy.
Results: Pompe disease is a life-threatening rare condition where prompt diagnosis is essential due to the availability of causative treatment. It is included in newborn screening programs for inherited metabolic disorders in some countries. Unfortunately, in Poland, routine diagnostic screening does not cover this disease. Implementing screening could simplify diagnosis and reduce the need for extensive differential diagnostics. Diagnosing late-onset Pompe disease can be challenging due to its diverse progression and symptoms. Patients with Pompe disease, even those receiving enzyme replacement therapy, require multidisciplinary care involving cardiology, pulmonology, neurology, and physical therapy.
A new method for evaluating radial neck fractures based on Judet classification
Authors: Wang Yi C. , Song Jiao J. , Li Ting T. , Yang Dan , Lv Zhi B. , Wang Zhen Y. , Zhang Zi M. , Luo Yi 
Published: September 2024

AimsTo propose a new method for evaluating paediatric radial neck fractures and improve the accuracy of fracture angulation measurement, particularly in younger children, and thereby facilitate planning treatment in this population.MethodsClinical data of 117 children with radial neck fractures in our hospital from August 2014 to March 2023 were collected. A total of 50 children (26 males, 24 females, mean age 7.6 years (2 to 13)) met the inclusion criteria and were analyzed. Cases were excluded for the following reasons: Judet grade I and Judet grade IVb (> 85° angulation) classification; poor radiograph image quality; incomplete clinical information; sagittal plane angulation; severe displacement of the ulna fracture; and Monteggia fractures. For each patient, standard elbow anteroposterior (AP) view radiographs and corresponding CT images were acquired. On radiographs, Angle P (complementary to the angle between the long axis of the radial head and the line perpendicular to the physis), Angle S (complementary to the angle between the long axis of the radial head and the midline through the proximal radial shaft), and Angle U (between the long axis of the radial head and the straight line from the distal tip of the capitellum to the coronoid process) were identified as candidates approximating the true coronal plane angulation of radial neck fractures. On the coronal plane of the CT scan, the angulation of radial neck fractures (CTa) was measured and served as the reference standard for measurement. Inter- and intraobserver reliabilities were assessed by Kappa statistics and intraclass correlation coefficient (ICC).ResultsAngle U showed the strongest correlation with CTa (p < 0.001). In the analysis of inter- and intraobserver reliability, Kappa values were significantly higher for Angles S and U compared with Angle P. ICC values were excellent among the three groups.ConclusionAngle U on AP view was the best substitute for CTa when evaluating radial neck fractures in children. Further studies are required to validate this method.Cite this article: Bone Joint J 2024;106-B(9):964–969.
The current role of CT in total knee arthroplasty
Authors: Mancino Fabio , Fontalis Andreas , Kayani Babar , Magan Ahmed , Plastow Ricci , Haddad Fares S. 
Published: September 2024

Advanced 3D imaging and CT-based navigation have emerged as valuable tools to use in total knee arthroplasty (TKA), for both preoperative planning and the intraoperative execution of different philosophies of alignment. Preoperative planning using CT-based 3D imaging enables more accurate prediction of the size of components, enhancing surgical workflow and optimizing the precision of the positioning of components. Surgeons can assess alignment, osteophytes, and arthritic changes better. These scans provide improved insights into the patellofemoral joint and facilitate tibial sizing and the evaluation of implant-bone contact area in cementless TKA. Preoperative CT imaging is also required for the development of patient-specific instrumentation cutting guides, aiming to reduce intraoperative blood loss and improve the surgical technique in complex cases. Intraoperative CT-based navigation and haptic guidance facilitates precise execution of the preoperative plan, aiming for optimal positioning of the components and accurate alignment, as determined by the surgeon’s philosophy. It also helps reduce iatrogenic injury to the periarticular soft-tissue structures with subsequent reduction in the local and systemic inflammatory response, enhancing early outcomes. Despite the increased costs and radiation exposure associated with CT-based navigation, these many benefits have facilitated the adoption of imaged based robotic surgery into routine practice. Further research on ultra-low-dose CT scans and exploration of the possible translation of the use of 3D imaging into improved clinical outcomes are required to justify its broader implementation.Cite this article: Bone Joint J 2024;106-B(9):892–897.
The effect of intra-articular autologous protein solution on knee osteoarthritis symptoms
Authors: Ross Marla , Zhou Yushy , English Michael , Sharplin Paul , Hirner Marc 
Published: September 2024

AimsKnee osteoarthritis (OA) is characterized by a chronic inflammatory process involving multiple cytokine pathways, leading to articular cartilage degeneration. Intra-articular therapies using pharmaceutical or autologous anti-inflammatory factors offer potential non-surgical treatment options. Autologous protein solution (APS) is one such product that uses the patient’s blood to produce a concentrate of cells and anti-inflammatory cytokines. This study evaluated the effect of a specific APS intra-articular injection (nSTRIDE) on patient-reported outcome measures compared to saline in moderate knee OA.MethodsA parallel, double-blinded, placebo-controlled randomized controlled trial was conducted, where patients with unilateral moderate knee OA (Kellgren-Lawrence grade 2 or 3) received either nSTRIDE or saline (placebo) injection to their symptomatic knee. The primary outcome was the difference in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score at 12 months post-intervention. Secondary outcomes included WOMAC component scores, Knee injury and Osteoarthritis Outcome Score (KOOS), and visual analogue scale (VAS) scores at all follow-up timepoints (three, six, and 12 months).ResultsA total of 40 patients were analyzed (21 nSTRIDE; 19 saline) in the study. No significant difference was found between nSTRIDE and saline groups for WOMAC total score at 12 months (mean difference -10.4 (95% CI -24.4 to 3.6; p = 0.141). There were no significant differences in WOMAC or KOOS scores across all timepoints. VAS scores favoured the saline group for both rest and worst pain scales at 12 months post-injection (mean difference (worst) 12 months 21.5 (95% CI 6.2 to 36.8; p = 0.008); mean difference (rest) 12 months 17.8 (95% CI 2.2 to 33.4; p = 0.026)). There were no adverse events recorded in either study group.ConclusionOur study demonstrates no significant differences between nSTRIDE and saline groups in KOOS and WOMAC scores over time. Notably, APS injection resulted in significantly worse pain symptoms at 12 months compared to saline injection.Cite this article: Bone Joint J 2024;106-B(9):907–915.
Biologics in rotator cuff repair
Authors: Savoie III Felix H. , Delvadia Bela P. , Tate Jackson P. , Winter Julianna E. , Williams Garrett H. , Sherman William F. , O’Brien Michael J. 
Published: September 2024

Rotator cuff tears are common in middle-aged and elderly patients. Despite advances in the surgical repair of rotator cuff tears, the rates of recurrent tear remain high. This may be due to the complexity of the tendons of the rotator cuff, which contributes to an inherently hostile healing environment. During the past 20 years, there has been an increased interest in the use of biologics to complement the healing environment in the shoulder, in order to improve rotator cuff healing and reduce the rate of recurrent tears. The aim of this review is to provide a summary of the current evidence for the use of forms of biological augmentation when repairing rotator cuff tears.Cite this article: Bone Joint J 2024;106-B(9):978–985.
Guanylate cyclase promotes osseointegration by inhibiting oxidative stress and inflammation in aged rats with iron overload
Authors: Tao Zhou-Shan , Shen Cai-Liang 
Published: September 2024

AimsThis study intended to investigate the effect of vericiguat (VIT) on titanium rod osseointegration in aged rats with iron overload, and also explore the role of VIT in osteoblast and osteoclast differentiation.MethodsIn this study, 60 rats were included in a titanium rod implantation model and underwent subsequent guanylate cyclase treatment. Imaging, histology, and biomechanics were used to evaluate the osseointegration of rats in each group. First, the impact of VIT on bone integration in aged rats with iron overload was investigated. Subsequently, VIT was employed to modulate the differentiation of MC3T3-E1 cells and RAW264.7 cells under conditions of iron overload.ResultsUtilizing an OVX rat model, we observed significant alterations in bone mass and osseointegration due to VIT administration in aged rats with iron overload. The observed effects were concomitant with reductions in bone metabolism, oxidative stress, and inflammation. To elucidate whether these effects are associated with osteoclast and osteoblast activity, we conducted in vitro experiments using MC3T3-E1 cells and RAW264.7 cells. Our findings indicate that iron accumulation suppressed the activity of MC3T3-E1 while enhancing RAW264.7 function. Furthermore, iron overload significantly decreased oxidative stress levels; however, these detrimental effects can be mitigated by VIT treatment.ConclusionCollectively, our data provide compelling evidence that VIT has the potential to reverse the deleterious consequences of iron overload on osseointegration and bone mass during ageing.Cite this article: Bone Joint Res 2024;13(9):427–440.
Health-related quality of life and mental health in patients with major bone and joint infections
Authors: Wetzel Katinka , Clauss Martin , Joeris Alexander , Kates Stephen , Morgenstern Mario 
Published: September 2024

AimsIt is well described that patients with bone and joint infections (BJIs) commonly experience significant functional impairment and disability. Published literature is lacking on the impact of BJIs on mental health. Therefore, the aim of this study was to assess health-related quality of life (HRQoL) and the impact on mental health in patients with BJIs.MethodsThe AO Trauma Infection Registry is a prospective multinational registry. In total, 229 adult patients with long-bone BJI were enrolled between 1 November 2012 and 31 August 2017 in 18 centres from ten countries. Clinical outcome data, demographic data, and details on infections and treatments were collected. Patient-reported outcomes using the 36-Item Short-Form Health Survey questionnaire (SF-36), Parker Mobility Score, and Katz Index of Independence in Activities of Daily Living were assessed at one, six, and 12 months. The SF-36 mental component subscales were analyzed and correlated with infection characteristics and clinical outcome.ResultsThe SF-36 physical component summary mean at baseline was 30.9 (95% CI 29.7 to 32.0). At one month, it was unchanged (30.5; 95% CI 29.5 to 31.5; p = 0.447); it had improved statistically significantly at six months (35.5; 95% CI 34.2 to 36.7; p < 0.001) and at 12 months (37.9; 95% CI 36.4 to 39.3; p < 0.001). The SF-36 mental component summary mean at baseline was 42.5 (95% CI 40.8 to 44.2). At one month, it was unchanged (43.1; 95% CI 41.4 to 44.8; p = 0.458); it had improved statistically significantly at six months (47.1; 95% CI 45.4 to 48.7; p < 0.001) and at 12 months (46.7; 95% CI 45.0 to 48.5; p < 0.001). All mental subscales had improved by the end of the study, but mental health status remained compromised in comparison with the average USA population.ConclusionBJIs considerably impact HRQoL, particularly mental health. Patients suffering from BJIs reported considerable limitations in their daily and social activities due to psychological problems. Impaired mental health may be explained by the chronic nature of BJIs, and therefore the mental wellbeing of these patients should be monitored closely.Cite this article: Bone Jt Open 2024;5(9):721–728.
Determinants of unmet need for contraceptive method among young married women in Ethiopia: Multilevel analysis of Ethiopia Demographic and Health Survey 2016
Authors: Turi Ebisa , Mamo Ayana Galana , Temesgen Sidise , Tafari Shama Adisu , Merga Bedasa Taye , Tolossa Tadesse 
Published: September 2024

Background
The notion of unmet need for family planning indicates the gap between women’s contraceptive practice and their reproductive intention. Although universal access to sexual and reproductive health services including contraceptive methods is a bedrock for sustainable development goals, the unmet need for contraception is high among young women in low-income countries including Ethiopia. The unmet need for contraception is associated with unintended pregnancy which most of the time end in unsafe abortion. Hence, this study aimed to assess the determinants of unmet need for family planning among young married women in Ethiopia using nationally representative data.

Method
This study utilized secondary data collected in the 2016 Ethiopia Demographic and Health Survey (EDHS). A two-stage cluster sampling method was used. The analysis included a total of 2444 sexually active married young women (15–24 years). Multilevel logistic regression analysis was conducted to identify individual and community level factors associated with unmet need for contraceptives and the results were presented as adjusted odds ratio (AOR) at 95% confidence interval (CI), declaring statistical significance at a p-value <0.05 in all analyses.

Results
In this study, the prevalence of unmet need for contraceptive method among married young women was 18.4% [95% CI: (16.9, 20.0)]. Female head of the household [AOR: 1.62, CI (1.25, 2.11)], primary level of education [AOR: 1.53, CI: (1.16, 2.03)], family size ≥5 [AOR: 1.53, 95%CI: (1.22, 1.93)], undecided to have child [AOR: 2.86, 95%CI: (1.58, 5.20)] and infecund [AOR: 1.54, 95%CI: (1.08, 2.20)] were factors positively associated with unmet need for family planning. Whereas the odds of unmet need for contraceptive method was lower among women-initiated sex between 15–17 years and >17 years [AOR:0.72, 95%CI (0.53, 0.98)] and [AOR: 0.58, 95%CI: (0.40, 0.85)] respectively and community with high proportion of poverty [AOR: 0.68, 95%CI: (0.46, 0.99)].

Conclusion
The prevalence of unmet need for contraceptive methods among young married women was relatively high. Being female household head, age at first sexual intercourse, educational status of the woman, family size, desire for more children, and community poverty were significantly associated with unmet need for family planning. Hence, interventions targeting these special populations at the individual and community level would play a paramount role in meeting the unmet need for contraception among young married women in Ethiopia.