bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haloperidol induced Parkinson’s disease mice model and motor-function modulation with Pyridine-3-carboxylic acid
Authors: Saeed Atif , Shakir Lubna , Khan Mahtab A. , Ali Arsalan , Zaidi Awais Ali 
Published: May 2017

Introduction: Motor-function modulation through Pyridine-3-carboxylic acid was assessed against. Haloperidol induced Parkinson’s disease (PD) in albino-mice. The objectives of this study were to test the effect of Haloperidol in development of PD, effectiveness of Pyridine-3-carboxylic acid in mice and evaluation of the motor-function changes in mice before and after treatment.
Methods: The study was divided into 3 phases: During Phase-I (randomization), all the subjects were randomly divided into 4 groups and trained for wire-hanging, grip strength, vertical rod and swim tests for 1 week. During Phase-II (disease induction), PD was induced by intra-peritoneal (ip) administration of Haloperidol (HP) in a dose of 1 mg/kg/d for 7 days. Group-A comprised of healthy controls, Group-B (Diseased), Group-C (HP+Pyridine-3-carboxylic acid 7.15 mg/kg/d) and Group-D (HP+Pyridine-3-carboxylic acid15 mg/kg/d).
Results: Pyridine-3-carboxylic acid treatment continued for 5 weeks. During Phase-III the above mention tests were performed and the effects of Pyridine-3-carboxylic acid were recorded. However, in swim test Group D is statistically insignificant as compared to Group B (p=0.284). In recent study, haloperidol is found to be effective in inducing motor function anomalies likewise in Parkinson’s disease including movement slowness, difficulties with gait and balance.
Conclusion: oral administration of Pyridine-3-carboxylic acid improved Motor-function changes in diseased mice. Therefore, it is concluded that Pyridine-3-carboxylic acid may help to alleviate PD symptoms.
Blood lactate level in Elite boy swimmers after lactate tolerance exercise test
Authors: Nikseresht Asghar , Yabande Iman , Rahmanian Karamatollah , Jahromi Abdolreza Sotoodeh 
Published: May 2017

Introduction: To avoid injuries during high-intensity sports training, it is important to recognize conditions of bodily consumption and production of adequate energy; exercise increases the concentration of the blood lactate. This paper is an attempt to compare pre and post lactate tolerance exercise test - blood lactate concentrations - of elite boy swimmers.
Methods: Blood lactates are measured by an enzymatic method on 12 subjects 30 minutes before and adjust and 24 hours after the test.
Results: The mean lactate concentration of 30.35±12.16 mg/dl is observed in swimmers 30 minutes before the test. Swimmers adjust after the test show mean blood lactate concentration of 108.52±18.17 mg/dl that is significantly higher than 30 minutes before the test (p<0.001). Then blood lactate level decreases below baseline level at 24 hours after the test.
Conclusion: Blood lactate increases with the test and decreases below baseline within 24 hours after the test.
Receptivity to Tobacco Advertising and Susceptibility to Tobacco Products
Authors: Pierce John P. , Sargent James D. , White Martha M. , Borek Nicolette , Portnoy David B. , Green Victoria R. , Kaufman Annette R. , Stanton Cassandra A. , Bansal-Travers Maansi , Strong David R. , Pearson Jennifer L. , Coleman Blair N. , Leas Eric , Noble Madison L. , Trinidad Dennis R. , Moran Meghan B. , Carusi Charles , Hyland Andrew , Messer Karen 
Published: May 2017

BACKGROUND AND OBJECTIVES:
Non–cigarette tobacco marketing is less regulated and may promote cigarette smoking among adolescents. We quantified receptivity to advertising for multiple tobacco products and hypothesized associations with susceptibility to cigarette smoking.

METHODS:
Wave 1 of the nationally representative PATH (Population Assessment of Tobacco and Health) study interviewed 10 751 adolescents who had never used tobacco. A stratified random selection of 5 advertisements for each of cigarettes, e-cigarettes, smokeless products, and cigars were shown from 959 recent tobacco advertisements. Aided recall was classified as low receptivity, and image-liking or favorite ad as higher receptivity. The main dependent variable was susceptibility to cigarette smoking.

RESULTS:
Among US youth, 41% of 12 to 13 year olds and half of older adolescents were receptive to at least 1 tobacco advertisement. Across each age group, receptivity to advertising was highest for e-cigarettes (28%–33%) followed by cigarettes (22%–25%), smokeless tobacco (15%–21%), and cigars (8%–13%). E-cigarette ads shown on television had the highest recall. Among cigarette-susceptible adolescents, receptivity to e-cigarette advertising (39.7%; 95% confidence interval [CI]: 37.9%–41.6%) was higher than for cigarette advertising (31.7%; 95% CI: 29.9%–33.6%). Receptivity to advertising for each tobacco product was associated with increased susceptibility to cigarette smoking, with no significant difference across products (similar odds for both cigarette and e-cigarette advertising; adjusted odds ratio = 1.22; 95% CI: 1.09–1.37).

CONCLUSIONS:
A large proportion of US adolescent never tobacco users are receptive to tobacco advertising, with television advertising for e-cigarettes having the highest recall. Receptivity to advertising for each non–cigarette tobacco product was associated with susceptibility to smoke cigarettes.
Az alvási apnoe szindróma vezető rizikótényezőinek esélyhányadosai
Authors: Szabó Krisztina , Ihász Ferenc 
Published: May 2017

Abstract: Introduction: The quality of sleep plays a serious role in the individual’s daytime performace and state of health, there by it has a strong influence on the society. Aim: The present study measures the probability developing and severity of obstructive sleep apnea syndrome, – which belongs to group of disorders of the respiratory – through odds ratio of leading risk factors. Method: 127 persons were examined in the test. The sleep structure test data were processed by polysomnographic screening device. Results: The nutritional level of body in mass index (BMI), and the neck circumferences data were recorded in cm. On the basis of the examination the gender as a risk factor it can be said that the odds ratio for men compared to women, more than three times higher of emergence of disease. Conclusions: Men’s chance of the emergence of serious disease is more than four times higher than women’s chance. In the men’s test group the most significant predictor of obstructive sleep apnea amongst the risk factors is the circumference according to odds ratio. In women’s group the leader odds ratio is BMI. More than 50% of test goup don’t report about daytime sleepiness, and this fact draws our attention to the role of risk factors’ odds ratio in selection. Orv Hetil. 2017; 158(21): 823–828.
Betegforgalmi trendek multidiszciplináris sürgősségi osztályon
Authors: Varga Csaba , Lelovics Zsuzsanna , Soós Viktor , Oláh Tibor 
Published: May 2017

Abstract: Introduction: More than twenty emergency departments were opened across Hungary in the past years. Data deficiency on patient flow, trends and lack of knowledge of indicators could raise numerous logistical and organisational problems. Aim: Collection, analysis and provision of data to facilitate successful operations of emergency medical care services. Method: During a three-year period investigated, at the multidisciplinary Emergency Department of “Moritz Kaposi” Teaching Hospital, data on patient flow (n = 106,203), epidemiology, triage and international classification of diseases were analysed. Results: Analysis showed 73% of patients were suitable for medical discharge within 24 hours. Predominantly internal medicine, paediatric and neurological diseases indicated hospitalisation (21%). Patients in critical condition were found to be low (<2%). Distinct diurnal, weekly, monthly variations were found. Majority of cases were injuries and intoxications (40%). Low mortality rate (0.3%) validates the effectiveness of stabilisation. Conclusions: The patient safety value of the examined emergency medical care is great, and could exempt the hospital wards from unjustified hospitalisations of the patients. Orv Hetil. 2017; 158(21): 811–822.
A gyermekkori malignus betegségek kezdeti tünettana
Authors: Papp Zsuzsanna Erzsébet , Kelemen Izabella , Horváth Adrienne 
Published: May 2017

Abstract: Introduction: Childhood malignant diseases are rare in pediatric pathology. Early symptoms are not specific, fatigue, pallor, compression signs and bone marrow failure are often mentioned. Aim: To summarize the most frequent early symptoms of childhood malignancies in order to help the physicians in the early recognition. Method: In our retrospective study, we processed a period of 5 years between 2012–2016, with an accent on the onset manifestations of malignancies. Results: In this period 34 cases were admitted with a diagnosis of malignant disease to our department. The most important symptoms were fever, fatigue, weight loss, pain, adenopathy, infections, and signs of anemia or thrombocytopenia. Conclusions: Childhood acute leukemia mostly occurs with adenopathy, fever, bone pain and signs of anemia. Solid tumors in their early stages may present with fatigue, pain and compression symptoms. The responsibility of the first physician is major in recognizing the most important early signs. Orv Hetil. 2017; 158(21): 829–834.
Országos Táplálkozás és Tápláltsági Állapot Vizsgálat – OTÁP2014. IV. A magyar lakosság mikroelem-bevitele
Authors: Nagy Barbara , Nagy-Lőrincz Zsuzsanna , Bakacs Márta , Illés Éva , Sarkadi Nagy Eszter , Erdei Gergő , Martos Éva 
Published: May 2017

Abstract: Introduction and aim: The Hungarian Diet and Nutritional Status Survey examined the dietary habits of the Hungarian population. This publication presents the microelement intake. Method: The survey represents the microelement intake of the Hungarian non-institutionalised adult population of 18 years and older. Results: While the intake of iron, copper and manganese corresponded with the recommendations in males, in females it was insufficient. The iron intake of women in their reproductive age (9.8 mg/d) stayed well below the recommendation, thus representing a high health risk. In comparison to earlier Hungarian data chromium intake decreased significantly in both sexes (men p = 0.000, women p = 0.008) and the zinc intake of men (9.6 mg/d) decreased below recommended. Conclusion: Since the consumption of whole grain products with high microelement content in Hungary is very low, it would be favourable to increase the proportion of these foods in the diet. In case of women it is also necessary to increase the consumption of food groups (e.g. meat, fruits) contributing to the iron intake. Furthermore, communication of adequate nutrition, and the availability of healthy foods is essential for the entire population. Orv Hetil. 2017; 158(21): 803–810.
USING REGIONAL RENEWABLE ENERGY RESOURSES FOR HEATING SUPPLY SYSTEMS
Authors: Pshinko O. M. , Gabrinets V. O. , Kuznetsov V. H. 
Published: May 2017

Purpose. The study analyzed the possibility and conditions for the effective operation of heating systems during the transition of the heat-generating capacity to biofuels energy. The straw of cereal crops, which are prevailing in Dnipro region, is used for this. The main purpose is scientific calculation of opportunities and cost of specific measures for such a transition. As an example it was taken the boiler-room of campus at Dnipropetrovsk National University of Railway Transport named after Academician V. Lazaryan (DNURT) that consumes natural gas. Methodology. The work analyses the legislative base of Ukraine, which promotes the using of renewable energy sources as fuel, as well as the incentive mechanisms for the development of this trend. The paper identifies opportunities of Prydniprovsk region to ensure straw supply for the boiler-room. Cost parameters of cargo transportation on the territory of Ukraine in 2016, which depend on the distance and the size of the trucks, are analysed. These indicators, as well as indicators related to its purchase, are considered together with energy potential of using the straw as fuel. Findings. With existing in Ukraine (as of 2016) the grain yielding capacity in the agriculture and cost indicators in the field of transportations, the transition of capacity share to biofuel is sufficiently profitable. The thermal power unit cost can be reduced fourfold. Originality. For the first time it is proposed to use the new integrated approaches to assess the cost of thermal power unit boiler with its transition to the use of renewable energy sources. The authors also proposed a new logistics delivery of these sources to the place of their application. From a technical and cost points of view it was determined the optimal order of capacity transfer for new renewable sources of energy in a given region depending on the structure of areas under crops and their productivity. Originality. The introduction of the proposed solutions and approaches to capacity boiler renewable energy sources can be realized with a relatively small investment and can provide significant economic benefits.
DETERMINATION OF DESIGN PARAMETERS OF ARTICULATED JIB SYSTEMS OF PORTAL CRANE
Authors: Suglobov V. V. , Tkachuk K. V. 
Published: May 2017

Purpose. The study involves: 1) formation of an array of geometry, weight and variable data for the automated synthesis of articulated jib systems; 2) development of methodology of calculation and determination of rational design parameters of the articulated jib systems, depending on the main technical parameters of the portal crane (maximum and minimum working radius, cargo lift height, tail radius value, carrying capacity of crane); 3) conducting of the study of the methodology adequacy on computer portal crane models. Methodology. To determine the kinematic characteristics of each link of the articulated jib system (boom, arm, jib tie, counterweight, load) we developed a dynamic and mathematical models that allow us to describe the movement of the articulated jib system when luffing. For the first time the technique of calculation and determination of rational design parameters of the articulated jib systems depending on the technical parameters of the portal crane. Findings. The conducted mathematical modeling allowed scientifically proving the usefulness of the proposed methodology for determining the design parameters of the articulated jib systems. The designed package of geometry, weight and variable data helps to simplify the process of preparatory calculations before the automated synthesis and to optimize the design of the articulated jib systems of portal cranes. Originality. For the first time the work proposes the technique for calculation of the parametric data that allow us to determine the rational design parameters of the articulated jib system. There are developed local programs for the integrated optimization synthesis that make it possible to select the best design option simultaneously by several quality criteria and functional constraints. Practical value. The proposed method of calculating the design parameters can be used in the design of new and modernization of existing portal cranes with the articulated jib systems, which, in turn, will reduce the material and energy consumption of the cranes.
The National Cancer Institute Community Cancer Centers Program (NCCCP): Sustaining Quality and Reducing Disparities in Guideline-Concordant Breast and Colon Cancer Care
Authors: Spain Pamela , Teixeira-Poit Stephanie , Halpern Michael T. , Castro Kathleen , Prabhu Das Irene , Adjei Brenda , Lewis Rebecca , Clauser Steven B. 
Published: May 2017

Abstract

Background
The National Cancer Institute Community Cancer Centers Program (NCCCP) pilot was designed to improve quality of cancer care and reduce disparities at community hospitals. The NCCCP's primary intervention was the implementation of the Commission on Cancer Rapid Quality Reporting System (RQRS). The RQRS is a hospital-based data collection and evaluation system allowing near real-time assessment of selected breast and colon cancer quality of care measures. Building on previous NCCCP analyses, this study examined whether improvements in quality cancer care within NCCCP hospitals early in the program were sustained and whether improvements were notable for minority or underserved populations.

Methods
We compared changes in concordance with three breast and two colon cancer quality measures approved by the National Quality Forum for patients diagnosed at NCCCP hospitals from 2006 to 2007 (pre-RQRS), 2008 to 2010 (early-RQRS), and 2011 to 2013 (later-RQRS). Data were obtained from NCCCP sites participating in the Commission on Cancer Rapid Quality Reporting System. Logistic regression analyses were performed to identify predictors of concordance with breast and colon cancer quality measures.

Results
The sample included 13,893 breast and 5,546 colon cancer patients. After RQRS initiation, all five quality measures improved significantly and improvements were sustained through 2013. Quality of care measures showed sustained improvements for both breast and colon cancer patients and for vulnerable patient subgroups including black, uninsured, and Medicaid-covered patients.

Conclusions
Quality improvements in NCCCP hospitals were sustained throughout the duration of the program, both overall and among minority and underserved patients. Because many individuals receive cancer treatment at community hospitals, facilitating high-quality care in these environments must be a priority.
Geriatric Assessment Predicts Survival and Competing Mortality in Elderly Patients with Early Colorectal Cancer: Can It Help in Adjuvant Therapy Decision-Making?
Authors: Antonio Maite , Saldaña Juana , Carmona-Bayonas Alberto , Navarro Valentín , Tebé Cristian , Nadal Marga , Formiga Francesc , Salazar Ramon , Borràs Josep Maria 
Published: May 2017

Abstract

Background
The challenge when selecting elderly patients with colorectal cancer (CRC) for adjuvant therapy is to estimate the likelihood that death from other causes will preclude cancer events from occurring. The aim of this paper is to evaluate whether comprehensive geriatric assessment (CGA) can predict survival and cancer-specific mortality in elderly CRC patients candidates for adjuvant therapy.

Material and Methods
One hundred ninety-five consecutive patients aged ≥75 with high-risk stage II and stage III CRC were prospectively included from May 2008 to May 2015. All patients underwent CGA, which evaluated comorbidity, polypharmacy, functional status, geriatric syndromes, mood, cognition, and social support. According to CGA results, patients were classified into three groups—fit, medium-fit, and unfit—to receive standard therapy, adjusted treatment, and best supportive care, respectively. We recorded survival and cause of death and used the Fine-Gray regression model to analyze competing causes of death.

Results
Following CGA, 85 (43%) participants were classified as fit, 57 (29%) as medium-fit, and 53 (28%) as unfit. The univariate 5-year survival rates were 74%, 52%, and 27%. Sixty-one (31%) patients died due to cancer progression (53%), non-cancer-related cause (46%), and unknown reasons (1%); there were no toxicity-related deaths. Fit and medium-fit participants were more likely to die due to cancer progression, whereas patients classified as unfit were at significantly greater risk of non-cancer-related death.

Conclusion
CGA showed efficacy in predicting survival and discriminating between causes of death in elderly patients with high-risk stage II and stage III resected CRC, with potential implications for shaping the decision-making process for adjuvant therapies.
SHOULDER INJURIES IN SWIMMING: REASONS
Authors: Solovjova Jelena , Upitis Imants , Dravniece Irena 
Published: May 2017

Swimming is one of the most popular recreational and competitive sporting activities. The repetitive nature of the swimming stroke and demanding training programs of its athletes raises a number of concerns regarding incidence and severity of injuries that a swimmer might experience during a competitive season. A number of risk factors have previously been identified but the level of evidence from individual studies, as well as the level of certainty that these factors predispose a swimmer to pain and injury. We have examined 134 leading swimmers, among them 50 female and 84 male aged between 11 and 18 years having trained from 1 to 9 years. In order to clarify the implementation of young swimmers shoulders areas state Latvian swimmers questioner‘s connected to shoulder area pain summarizing was used. We figure out, that in all swimmers groups is evidence tendency- pain in shoulders area appears when swimming in small or big paddles, using swimming resistance and in fast interval training. From all four swimmer groups –Most’’ successful’’ group is 11-12 years old swimmers. From 25 respondents in this age group answer about feeling pain often -1 swimmers, when swimming fly and one –when swimming freestyle. But when swimming with paddles – more complaints, when swimming in big paddles-8 answers and in small paddles-6 answers. The largest number -9 answers about pain, when swimming long distances using one stroke. The total number of positive answers is dominated by the age group 13-14 years. The greatest manifestation of painful sensations when swimming in the shoulder blades, with intense swimming and when using swimming resistances equipment. A similar trend is observed in the group of 15-16 year old. However, the number of complaints is less than in the group of 13-14 year old. On pain during swimming in the shoulder blades, 15 and 20 swimmers complain, respectively. In the older group, 17-18 years- the least number of complaints, although swimming in big paddles often causes pain.
CONCEPTUALISATION OF CULTURE PHENOMENA BY PRE-SERVICE TEACHERS OF FOREIGN LANGUAGES
Authors: Mazlaveckiene Gerda 
Published: May 2017

Cultural awareness has become the centre of modern language education that reflects a greater understanding of the inseparability of language and culture, as well as the need to train students for intercultural communication in the globalised world. Realising it or not, language teachers cannot avoid conveying impressions of another culture: language cannot be separated from the culture in which it is embedded\. Therefore, while training a future teacher of a foreign language it is essential to develop his/her cultural awareness, i.e. the knowledge and understanding of the conventions, customs and beliefs of another culture, as well as abilities to interpret, relate and provide critical judgement of one’s native and foreign cultures. Hence, the current article focuses on the conceptualisation of culture phenomena of pre-service teachers of foreign languages. It presents the results of a questionnaire survey conducted at five universities of Lithuania in 2014. The research sample involved 504 pre-service teachers of foreign languages (English, German, French, Polish and Russian), who completed a questionnaire survey consisting of both closed-ended and open-ended questions. The future teachers’ conceptualisation of culture was analysed as twofold: perception and awareness of culture forms of the countries of the native and target languages, as well as their involvement in cultural activity.