bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface changes of various bulk‐fill resin‐based composites after exposure to different food‐simulating liquid and beverages
Authors: Tanthanuch Saijai , Kukiattrakoon Boonlert , Eiam‐O‐Pas Kasidit , Pokawattana Kan , Pamanee Nicha , Thongkamkaew Wichachon , Kochatung Asok 
Published: November 2017

AbstractObjectiveTo evaluate surface roughness, hardness, and morphology changes of various bulk‐fill resin composites eroded by different food‐simulating liquids and beverages.Materials and MethodsOne hundred and thirteen specimens were fabricated in polytetrafluoroethylene cylindrical mold (10 mm in diameter and 4 mm in thickness). Before immersion, baseline data of roughness, Vicker's microhardness were recorded and surface characteristics were examined using scanning electron microscopy (SEM). Each product of specimens (SDR, Dentsply; SonicFill, Kerr; Tetric N‐Ceram Bulk Fill, Ivoclar Vivadent AG; and Filtek Bulk Fill, 3M ESPE) were divided into 5 groups for spicy and sour soup, spicy soup (Tom Yum), pineapple juice, passionfruit juice, and deionized water (served as a control). Specimens were then alternately immersed in storage agents for 5 seconds and artificial saliva for 5 seconds over 10 cycles. Specimens were stored in artificial saliva for 22 hours. This process was repeated for 28 days. After immersion, surface hardness and roughness of specimens were evaluated at 7, 14, 21, and 28 days and data were analyzed by two‐way repeated ANOVA and Tukey's HSD (α = 0.05). Surface morphology of specimens was also examined on day 28.ResultsThe SDR group had the most statistically significant decrement in hardness (25.65 ± 1.74 kg/mm2 in mean difference) and increment in roughness (0.26 ± 0.10 μm in mean difference; P < .05). Passionfruit juice caused the most surface changes in bulk‐fill resin composites. SEM photomicrographs showed surface changes of all resin composites in varying degrees.ConclusionAcidic food‐simulating liquids and beverages significantly increased the surface roughness and decreased surface microhardness of bulk‐fill resin composites after evaluation at the end of the 28‐day immersion period.Clinical significanceFor restoration of the affected teeth in patients who consume acidic food and beverages, roughness and erosion of resin composites should be considered. All of bulk‐fill resin‐based composites except SDR may be suitable for restorations in these patients.
Interleukin‐6 regulates expression of Fos and Jun genes to affect the development of mouse preimplantation embryos
Authors: Yu Chunhua , Zhang Xinyan , Wang Li , Liu Yinan , Li Na , Li Min , Chen Li , Liu Yingyu , Yao Yuanqing 
Published: November 2017

AbstractAimWe investigated whether recombinant mouse interleukin‐6 (IL‐6) affects the development of preimplantation embryos and induces the ‐signal transducers and activators of transcription (JAK–STAT) signaling pathway by binding IL‐6 signal transducer (IL‐6st) and regulating Fos and Jun gene expression, thereby accounting for the negative effect of superovulation on embryo development.MethodsWe compared rates of blastocyst formation from embryos cultured with different concentrations of IL‐6 or/and anti‐interleukin 6 receptor antibody (anti‐IL‐6RAb) in superovulated experimental and normal control groups. IL‐6 expression in preimplantation embryos was determined by immunofluorescence identification. Fos, Jun and IL‐6st messenger RNA expression was detected by PCR and microarray experiments.ResultsRates of blastocyst formation significantly decreased in superovulated embryos, whether or not they were incubated in 0.1, 1, 25 or 50 pg/mL IL‐6, (P < 0.01) compared to embryos from naturally ovulated controls, whereas incubation in 5 and 10 pg/mL IL‐6 reversed the negative effects of superovulation. The addition of anti‐IL‐6RAb to naturally ovulated embryos reduced blastocyst rates to those of superovulated embryos. Gene chip analysis indicated that the JAK–STAT signaling pathway contained differentially expressed IL‐6, IL‐6st, Jun and Fos genes. Both anti‐IL‐6RAb or ovarian stimulation downregulated IL‐6st, Jun, and Fos messenger RNA expression, but expression of the same three genes increased in 5 pg/mL IL‐6.ConclusionOvarian stimulation negatively impacts the development of preimplantation embryos by reducing IL‐6 release. IL‐6 affects the rate of development of zygotes to blastocyst by regulating IL‐6st, Fos and Jun expression in the JAK–STAT signaling pathway.
Predictive factors for emergent surgical intervention in patients with ovarian endometrioma hospitalized for pelvic inflammatory disease: A retrospective observational study
Authors: Matsuyama Reiko , Tsuchiya Akira , Nishii Osamu 
Published: November 2017

AbstractAimThe aim of this study was to identify predictive factors for emergent surgical interventions in patients with ovarian endometriomas hospitalized for pelvic inflammatory disease (PID).MethodsWe retrospectively identified 22 patients with ovarian endometriomas who were hospitalized to manage PID. Patients were divided into two groups: those who required emergent surgery after failed antibiotic therapy (emergent surgery group, n = 6) and those who were discharged with successful antibiotic therapy (conservative group, n = 16). Logistic regression analysis was performed to analyze the factors associated with emergent surgery.ResultsPatients in the emergent surgery group were significantly more likely to have intrauterine or intrapelvic procedures before the onset of PID compared to those in the conservative group (83% vs 38%, odds ratio 8.33, 95% confidence interval 1.02–181.3; P = 0.048). The mean interval between the onset of PID symptoms and the commencement of parenteral antibiotic therapy was significantly longer in the emergent surgery compared to the conservative group (6.5 vs 1 day, odds ratio 1.28, 95% confidence interval 1.01–1.75; P = 0.041).ConclusionA history of an intrauterine or intrapelvic procedure before the onset of PID was more likely to result in emergent surgery. A longer interval between the onset of PID symptoms and the commencement of parenteral antibiotics was also associated with emergent surgery. These findings could help to identify patients with ovarian endometriomas hospitalized with PID at higher risk of emergent surgical intervention.
A randomized study of prourokinase during primary percutaneous coronary intervention in acute ST‐segment elevation myocardial infarction
Authors: Geng Wei , Zhang Qi , Liu Jingmin , Tian Xiang , Zhen Libo , Song Da , Yang Ying , Meng Haiyun , Wang Yafang , Chen Jianjun 
Published: November 2017

ObjectivesTo evaluate the efficacy and safety of intracoronary administration of prourokinase via balloon catheter during primary percutaneous coronary interventions (PCI) in patients with acute ST‐segment elevation myocardial infarction (STEMI).MethodsAcute STEMI patients underwent primary PCI were randomly divided into two groups: intracoronary prourokinase (IP) group (n = 118) and control group (n = 112). During primary PCI, prourokinase or saline were injected to the distal end of the culprit lesion via balloon catheter after balloon catheter dilatation. Demographic and clinical characteristics, infarct size, myocardial reperfusion, and cardiac functions were evaluated and compared between two groups. Hemorrhagic complications and MACE occurred in the 6‐months follow up were recorded.ResultsNo significant differences were observed between two groups with respect to baseline demographic, clinical, and angiographic characteristics (P > 0.05). In IP group, more patients had complete ST segment resolution (>70%) compared with control group (P < 0.05). Patients in IP group showed lower levels of serum CK, CK‐MB and TnI, and a much higher myocardial blood flow (MBF) than those in control group (P < 0.05). No significant differences of TIMI major or minor bleeding complications were observed between the two groups (P > 0.05). At 6‐months follow‐up, there was a trend that patients in the IP group had a less chance to have MACE, though it was not statistically different (8.5% vs 12.5%, P > 0.05).ConclusionsIntracoronary administration of prourokinase via balloon catheter during primary PCI effectively improved myocardial perfusion in STEMI patients.
Risk of inferior alveolar nerve injury with coronectomy vs surgical extraction of mandibular third molars—A comparison of two techniques and review of the literature
Authors: Ali A. S. , Benton J. A. , Yates J. M. 
Published: November 2017

SummaryThe removal of mandibular third molar teeth is one of the most common oral surgical procedures. In a significant number of patients, it carries a degree of associated morbidity, including damage to the inferior alveolar nerve (IAN). For this reason, practitioners desire the most up‐to‐date guidance on the most appropriate technique, informed by the best available evidence that will produce the lowest incidence of iatrogenic complications. The aim of this study was to perform a systematic review comparing the effect of coronectomy vs complete surgical extraction of mandibular third molar teeth on the risk of IAN injury and other complications in adults. Studies were identified through Embase (1980‐2016) and Ovid MEDLINE (1946‐2016) database searches. Search terms included coronectomy, partial root removal, deliberate vital root retention, odontectomy, surgical removal, surgical extraction, complete tooth extraction and extract. Limits of the study included humans, English language and randomised controlled trials (RCTs). Only RCTs comparing IAN damage associated with surgical extraction of mandibular third molars vs coronectomy were included. From our database searches, we identified two unique RCTs matching the inclusion criteria. Both evaluated patients who had specific radiographic signs of intimate relationships with the IAN. Upon detailed analysis, the studies were noted to exhibit a high risk of bias in many categories, thereby rendering their results inconclusive. Although evidence from two RCTs suggests that coronectomy can reduce the risk of IAN injury compared to surgical removal of high‐risk mandibular third molars, the quality of evidence is insufficient to provide definitive conclusions regarding the preferred technique.
Upregulation of angiogenesis in oral lichen planus
Authors: Al‐Hassiny A. , Friedlander L. T. , Parachuru V. P. B. , Seo B. , Hussaini H. M. , Rich A. M. 
Published: November 2017

ObjectivesAs angiogenesis is fundamental to the pathogenesis of many chronic inflammatory disorders, this study investigated the expression of various vascular markers in oral lichen planus and non‐specific oral mucosal inflammatory tissues.MethodsArchival specimens of oral lichen planus (n = 15) and inflamed tissues (n = 13) were stained using immunohistochemistry with antibodies to CD34, vascular endothelial growth factor, vascular endothelial growth factor receptor and vasohibin. Nine representative sites at the epithelial‐connective tissue junction and through the fibrous connective tissue were selected, and automated analysis techniques were used to determine the extent of positivity expressed as the percentage of positive cells. Significance was denoted when P < .05.ResultsThe expression of pro‐angiogenic factors was higher in lichen planus samples compared with inflamed controls. A higher level of CD34 was observed in the deeper parts of the connective tissue of Oral lichen planus (OLP) (P = .04), whereas VEGF and VEGFR2 expressions were higher all through the tissues (respectively, P < .02 and P < .01). The expression of the anti‐angiogenic VASH1 was higher in inflamed tissue compared with lichen planus in all sites evaluated (P < .01).ConclusionsThe findings indicate that angiogenic factors are differentially expressed in oral lichen planus compared with inflamed controls, with increased expression of pro‐angiogenic factors and decreased anti‐angiogenic expression.
Post‐temporary ligation intraoperative mesenteric portovenography: comparison with CT angiography for investigation of portosystemic shunts
Authors: Parry A. T. , White R. N. 
Published: November 2017

ObjectivesComparison of pre‐operative CT angiography and post‐temporary, full‐ligation, intraoperative, mesenteric portovenography for the characterisation of intrahepatic portal vasculature in patients with single extrahepatic portosystemic shunts.MethodsDescriptive analysis of previously collected images from 14 dogs and five cats.ResultsWith the exception of shunts involving the right gastric vein, intrahepatic arborisation appeared similar on both modalities. Portovenography improved contrast enhancement and slightly enlarged the intrahepatic portal vasculature.Clinical SignificanceCT angiography cannot replace intraoperative mesenteric portovenography after temporary full ligation, which provides information on intrahepatic portal vascularity. It is a practical and dynamic procedure, providing results that are instantaneously available at the time of surgery. In addition, intraoperative post‐temporary, full‐ligation, mesenteric portography confirmed that the single shunting vessel had both been recognised and ligated.
The prevalence of narcolepsy in Catalunya (Spain)
Authors: Tió Ester , Gaig Carles , Giner‐Soriano Maria , Romero Odile , Jurado Maria‐José , Sansa Gemma , Pujol Montse , Sans Oscar , Álvarez‐Guerrico Ion , Caballol Nuria , Jimenez Marta , Becerra Juan‐Luis , Escartin Antonio , Monasterio Carmen , Molins Albert , Bove Antoni , Viña Jaume , Iranzo Alex , Cambrodi Roser , Calvo Gonzalo , Morros Rosa , Santamaria Joan 
Published: November 2017

SummaryPrevious studies have estimated an overall prevalence for narcolepsy between 15 and 70 cases per 100 000 inhabitants. We aimed to estimate the prevalence of narcolepsy in Catalunya (Catalonia), a north‐east region of Spain (7 424 754 inhabitants), on 31 December 2014 by identifying all living subjects diagnosed with narcolepsy. First, we identified patients diagnosed by one of the 13 sleep, paediatric or neurological departments that perform tests regularly to diagnose narcolepsy. In a second phase, we searched for additional patients with narcolepsy in a clinical database of the primary health‐care system. Clinical files were reviewed and narcolepsy diagnosis validated according to the Brighton Collaboration case definitions. Three hundred and twenty‐five patients had a validated diagnosis of narcolepsy in the specialized centres (mean age: 44.6 years, range: 6–89; male: 60.3%; 85% with narcolepsy type 1), including 17.8% cases in Brighton, definition level 1, 62.5% in level 2, 15.4% in level 3 and 4.3% in level 4a. The overall prevalence for narcolepsy was 4.4; 3.7 for narcolepsy type 1 and 0.7 cases per 100 000 inhabitants for narcolepsy type 2. Fifty‐six additional narcoleptic patients were identified in the primary health‐care system, increasing the overall prevalence to 5.2 cases per 100 000 inhabitants. Prevalence rates for narcolepsy type 1 increased from childhood to adulthood, but in subjects aged more than 50 years there was a substantial drop in prevalence rates, suggesting the presence of a significant pool of undiagnosed cases in this population. Narcolepsy can be considered a rare neurological disorder in Catalunya.
Maternal prepregnancy BMI or weight and offspring's blood pressure: Systematic review
Authors: Ludwig‐Walz Helena , Schmidt Milan , Günther Anke L. B. , Kroke Anja 
Published: November 2017

AbstractEmerging evidence suggests that maternal prepregnancy body mass index or weight (MPBW) may be associated with offspring's blood pressure (BP). Therefore, we conducted a systematic review—following the Preferred Reporting Items for Systematic Reviews and Meta‐analyses statement—to assess and judge the evidence for an association between MPBW with offspring's later BP. Five data bases were searched without limits. Risk of bias was assessed using the “Tool to Assess Risk of Bias in Cohort Studies,” and an evidence grade was allocated following the World Cancer Research Fund criteria. Of 2,011 publications retrieved, 16 studies (all cohort studies) were included in the systematic review; thereof, 5 studies (31%) were rated as good‐quality studies. Overall, data from 63,959 participants were enclosed. Systolic BP was analysed in 15 (5 good quality), diastolic BP in 12 (3 good quality), and mean arterial pressure in 3 (no good quality) studies. Five good‐quality studies of MPBW with offspring's systolic BP as the outcome and 1 good‐quality study with offspring's diastolic BP as the outcome observed a significant association. However, after adding offspring's anthropometry variables to the statistical model, the effect attenuated in 4 studies with systolic BP to nonsignificance, the study with diastolic BP remained significant. No good‐quality studies were found with respect to offspring's later mean arterial pressure. In conclusion, this systematic review found suggestive, but still limited, evidence for an association between MPBW with offspring's later BP. The available data suggest that the effect might be mainly mediated via offspring's anthropometry.
The Influence of Self‐Efficacy, Fear‐Avoidance Belief, and Coping Styles on Quality of Life for Chinese Patients with Chronic Nonspecific Low Back Pain: A Multisite Cross‐Sectional Study
Authors: Du Shizheng , Hu Lingli , Bai Yamei , Dong Jianshu , Jin Shengji , Zhang Heng , Zhu Ying 
Published: November 2017

AbstractBackgroundAs a bio‐psycho‐social issue, chronic low back pain (CLBP) has been a significant topic in health management, and patients' quality of life (QOL) is gaining extensive attention. Self‐efficacy, pain fear‐avoidance belief (FAB), and coping styles play important roles in the QOL of CLBP patients. However, it remains unclear how self‐efficacy and FAB influence QOL through specific coping styles. This study aimed to explore the influencing paths of self‐efficacy, FAB, and coping styles on the QOL of patients with CLBP.MethodsThis study relies on a multisite, cross‐sectional design involving 221 CLBP patients. Stepwise multiple regression and structural equation modeling were employed.ResultsCLBP patients lived with a poor global QOL. Self‐efficacy played a direct, positive role in predicting QOL for patients with CLBP (β = 0.35), and it also played an indirect, positive role in predicting QOL (β = 0.19) through active coping styles (β = 0.31). FAB played a direct, negative role in predicting QOL (β = −0.33), and it also played an indirect, negative role in predicting QOL (β = −0.32) through passive coping styles (β = 0.32).ConclusionsSelf‐efficacy and FAB are both directly and indirectly related to global QOL, and coping styles are important mediating variables. Self‐efficacy and active coping are protective factors for the QOL of CLBP patients, while FAB and passive coping are risk factors. Health education strategies are recommended by medical personnel to enhance CLBP patients' pain self‐efficacy, decrease pain FAB, and modify pain coping styles, so that their global QOL can be improved.
CPAP by helmet for treatment of acute respiratory failure after pediatric liver transplantation
Authors: Chiusolo F. , Fanelli V. , Ciofi degli Atti M. L. , Conti G. , Tortora F. , Pariante R. , Ravà L. , Grimaldi C. , de Ville de Goyet J. , Picardo S. 
Published: November 2017

AbstractARF after pediatric liver transplantation accounts for high rate of morbidity and mortality associated with this procedure. The role of CPAP in postoperative period is still unknown. The aim of the study was to describe current practice and risk factors associated with the application of helmet CPAP. In this retrospective observational cohort study, 119 recipients were divided into two groups based on indication to CPAP after extubation. Perioperative variables were studied, and determinants of CPAP application were analyzed in a multivariate logistic model. Sixty patients (60/114) developed ARF and were included in the CPAP group. No differences were found between the two groups for primary disease, graft type, and blood product transfused. At multivariate analysis, weight <11 kg (OR = 2.9; 95% CI = 1.1‐7.3; P = .026), PaO2/FiO2 <380 before extubation (OR = 5.4; 95% CI = 2.1‐13.6; P < .001), need of vasopressors (OR = 2.6; 95% CI = 1.1‐6.4; P = .038), and positive fluid balance >148 mL/kg (OR = 4.0; 95% CI = 1.6‐10.1; P = .004) were the main determinants of CPAP application. In the CPAP group, five patients (8.4%) needed reintubation. Pediatric liver recipients with lower weight, higher need of inotropes/vasopressors, higher positive fluid balance after surgery, and lower PaO2/FiO2 before extubation were at higher odds of developing ARF needing CPAP application.
Location decisions of non‐bank financial foreign direct investment: Firm‐level evidence from Europe
Authors: Davies Ronald B. , Killeen Neill 
Published: November 2017

AbstractThe non‐bank financial sector in Europe has more than doubled in size between 2005 and 2015 reflecting the substantial growth in shadow banking activities. However, a large proportion of the non‐bank financial sector that remains unmapped as granular balance sheet information is not available for over half of the sector. Motivated by these data gaps and employing firm‐level data, this paper examines the location decisions of newly incorporated foreign affiliates in the non‐bank financial sector across 27 European countries over the period 2004 to 2012. The probability of a country being chosen as the location for a new foreign affiliate is found to be negatively associated with higher corporate tax rates and geographic distance but increases with the size and financial development of the host country. The financial regulatory regime in the host country and gravity related controls such as the home and host country sharing a common legal system, language, border, and currency are also found to impact the likelihood of non‐bank financial FDI.
Policy and performance in customs: Evaluating the trade facilitation agreement
Authors: Hillberry Russell , Zhang Xiaohui 
Published: November 2017

AbstractThis paper links cross‐country variation in trade facilitation policies to prominent indicators of national customs and logistics performance. We test the hypotheses that the policy data explain variation in the performance indicators, independent of other country characteristics that are plausibly exogenous to changes in trade facilitation policies. We use a LASSO procedure to choose among the many potential explanatory variables in the model. In general we find that country characteristics related to geography, income, and the general quality of governance better explain cross‐country variation in customs and logistics performance than do the measures of trade facilitation policy.
Beyond Polycentricity: Does Stronger Integration Between Cities in Polycentric Urban Regions Improve Performance?
Authors: Meijers Evert , Hoogerbrugge Marloes , Cardoso Rodrigo 
Published: November 2017

AbstractA quarter of the European population lives in ‘polycentric urban regions’ (PURs): clusters of historically and administratively distinct but proximate and well‐connected cities of relatively similar size. This paper explores whether tighter integration can increase agglomeration benefits at the PUR‐level. We provide the first comprehensive list of European PURs (117 in total), establish their level of functional, institutional and cultural integration and measure whether this affects their performance. ‘Performance’ is defined as the extent to which urbanisation economies have developed, proxied by the presence of metropolitan functions. In this first‐ever cross‐sectional analysis of PURs we find that while there is evidence for all dimensions of integration having a positive effect, particularly functional integration has great significance. Regarding institutional integration, it appears that having some form of metropolitan co‐operation is more important than its exact shape. Theoretically, our results substantiate the assumption that networks may substitute for proximity.