bluuebunny/crossref_metadata_2025_split huggingface dataset:
A microfluidic module for real-time generation of complex multi-molecule temporal concentration profiles
Authors: Woodruff Kristina , Maerkl Sebastian J. 
Published: March 2017

AbstractWe designed a microfluidic module that generates complex, dynamic concentration profiles of multiple molecules over a large concentration range using pulse-width modulation (PWM). Our PWM device can arbitrarily combine up to 6 different inputs and select between three downstream mixing channels as required by the application. The module can produce arbitrary concentrations with a dynamic range of up to 3-5 decades. We created complex concentration profiles of 2 molecules, with each concentration independently controllable, and show that the PWM module can execute rapid concentration changes as well as long-timescale pharmacokinetic profiles. Concentration profiles were generated for molecules with molecular weights ranging from 560 Da to 150 kDa. Our PWM module produces robust and precise concentration profiles under a variety of operating conditions, making it ideal for integration with existing microfluidic devices for advanced cell and pharmacokinetic studies.
Selectivity profile of the poly(ADP-ribose) polymerase (PARP) inhibitor, A-966492
Authors: Thorsell Ann-Gerd , Schüler Herwig 
Published: March 2017

AbstractAmong the clinical inhibitors of poly(ADP-ribose) polymerases (PARPs) and the commonly used PARP research tool compounds, veliparib and niraparib were recently identified as the most selective inhibitors of PARP1 and PARP2. We characterized the potency of A-966492, a PARP inhibitor with a chemical structure similar to veliparib and niraparib, inin vitroinhibition experiments of six PARP family enzymes. We find that the selectivity of A-966492 for PARP1 and PARP2 is intermediate between veliparib and niraparib.
Walking behavior in a circular arena modified by pulsed light stimulation inDrosophila melanogaster w1118line
Authors: Qiu Shuang , Xiao Chengfeng 
Published: March 2017

ABSTRACTTheDrosophila melanogasterwhite-eyedw1118line serves as a blank control, allowing genetic recombination of any gene of interest along with a readily recognizable marker.w1118flies display behavioral susceptibility to environmental stimulation such as light. It is of great importance to characterize the behavioral performance ofw1118flies because this would provide a baseline from which the effect of the gene of interest could be differentiated. Little work has been performed to characterize the walking behavior in adultw1118flies. Here we show that pulsed light stimulation increased the regularity of walking trajectories ofw1118flies in circular arenas. We statistically modeled the distribution of distances to center and extracted the walking structures ofw1118flies. Pulsed light stimulation redistributed the time proportions for individual walking structures. Specifically, pulsed light stimulation reduced the episodes of crossing over the central region of the arena. An addition of four genomic copies of mini-white, a common marker gene for eye color, mimicked the effect of pulsed light stimulation in reducing crossing in a circular arena. The reducing effect of mini-whitewas copy-number-dependent. These findings highlight the rhythmic light stimulation-evoked modifications of walking behavior inw1118flies and an unexpected behavioral consequence of mini-whitein transgenic flies carryingw1118isogenic background.
Critical success factors for local government project stakeholder management
Authors: Amoatey Charles , Hayibor Mawuena Vincent Kodzo 
Published: March 2017

Purpose
The purpose of this paper is to investigate the critical success factors (CSFs) for effective project stakeholder management at the local government level in Ghana.

Design/methodology/approach
The study used data from questionnaires administered to project stakeholders for identifying and ranking CSFs.

Findings
The study identified the top five CSFs for stakeholder management at the local government level in Ghana to be: communicating with and engaging stakeholders; identifying stakeholders properly; formulating a clear project mission statement; keeping and promoting good relationships; and analyzing stakeholder conflicts and coalitions.

Research limitations/implications
Generalization of the findings should be done with caution since the scope of data collection was limited to district assemblies in the Greater Accra region of Ghana. Nevertheless the results of the study are, however, useful and indicative and can lend direction to future research.

Practical implications
This paper has contributed to the growing body of knowledge related to CSFs for local government projects. The results should help understand factors which are of priority to stakeholders when assessing their involvement in projects. Further, the findings could form the basis for competency development of local government personnel in specific areas where improvements are required.

Originality/value
The paper identified CSFs for effective project stakeholder management at the local level. Most studies on critical factors in project environments have focused on CSFs and project success and thus this study delves into an area which has not received much attention in the literature.
A passion for fashion
Authors: Loureiro Sandra Maria Correia , Costa Inês , Panchapakesan Padma 
Published: March 2017

Purpose
The purpose of this paper is to explore the effect of social influence and individual vanity on passion for fashion of clothes and accessories and the mediating role of exhibitionist tendency.

Design/methodology/approach
The study was conducted in two phases. The first was exploratory (n=109), using online panel interviews, carried out among a sample of fashion enthusiasts. The quantitative phase (n=425). Shopping mall intercept field survey methodology has been utilised to collect data. Consumers who just completed their shopping and were about to leave the shopping malls were approached by trained interviewers.

Findings
The content analysis of phase 1 yielded four major aspects and more two aspects less cited that participants seek in posts and online information that motivate them for shopping, such as inspirational outfits, products and brands posted, self-identification with the style, value for money, friends and fashion magazines and runway shows. The findings of phase 2 reveal that the social influence is more important than individual vanity in enhancing the desire to buy and use fashion clothes and accessories. Further, the exhibitionist tendency acts as a mediator between passionate desire for fashion and self-expression word-of-mouth.

Originality/value
As far as authors know, this is the first attempt to explore the effect of two components of narcissism in fashion context and to analyse the social and individual influence on passionate desire to use fashion.
Exchange transactions revisited: on the universal applicability of homo economicus
Authors: Dixon John 
Published: March 2017

PurposeThe purpose of this paper is to provide a comprehensive classification ofquid pro quoexchange transactions, so as to distinguish the different ways that desired exchange outcomes can be determined and that transactional processes can be conducted. This permits reflection on the generality of the theory of the individual embedded in neoclassical (orthodox) economics.Design/methodology/approachThe approach adopted is to draw upon the contending dichotomies in epistemology (naturalism or hermeneutics) and ontology (agency or structure) to demarcate and depict a set of Weberian archetypal social actors, so as to explore their cognitions and behaviors in a transactional arena. These archetypal social actors are hypothetical role-playing actors – they do not describe real people.FindingsThese archetypal social actors, collectively, are suggestive of the profuseness of ways people can engage in exchange transactions. Each archetype’s credibility is contingent upon the veracity of its ontological and epistemological standpoints. Each, indeed, has blindspots that permit the denied standpoints to be ignored without analytical detriment. None can, therefore, claim the status of a general theory of exchange process.Originality/valueThe paper’s originality is that it explores exchange transactions from a variety of epistemological and ontological perspectives.
Extreme luxury fashion: business model and internationalization process
Authors: Guercini Simone , Milanesi Matilde 
Published: March 2017

PurposeThe purpose of this paper is to identify the defining characteristics of the extreme luxury fashion business model (ELFBM) and the relationship between this business model and the process of firm internationalization. The paper examines the potentially positive outcomes of differences and distances in the internationalization process of extreme luxury fashion companies.Design/methodology/approachThe paper presents and discusses the data collected during a five-year case analysis of an Italian luxury company. The main characteristics of the business model are identified in terms of products, manufacturing and sourcing, distribution channels, marketing communications and overall characteristics of consumers. The internationalization process is described, with a focus on the Russian market as an emblematic case, highlighting the role of distances – geographic, psychic and cultural – and liabilities, namely foreignness and outsidership in the international expansion of the firm.FindingsThe findings of this paper highlight the main features and specific traits of the ELFBM characterized by a global and unique approach to the offer. This business model has in its origin the demand from certain foreign markets, and the elements of the country of origin of the firms coexist and are enhanced by the presence of specific characteristics of the destination countries in terms of niche consumers with economic and cultural characteristics and a strong perception of “Made in” and luxury goods.Originality/valueThe paper contributes to previous studies on the relationships between business models and internationalization. It provides a framework for the “ELFBM,” in which internationalization is a constitutive element of a specific business model rather than a strategy for a business model already defined. Examining the positive side of differences and distances in the internationalization process of firms adopting such business model, the paper contributes to the international business theory and practice. It also expands research on luxury fashion defining an international company which is under-investigated, the extreme luxury fashion company, and the elements that constitute its business model.
What people study when they study Tumblr
Authors: Attu Rose , Terras Melissa 
Published: March 2017

Purpose
Since its launch in 2007, research has been carried out on the popular social networking website Tumblr. The purpose of this paper is to identify published Tumblr-based research, classify it to understand approaches and methods, and provide methodological recommendations for others.

Design/methodology/approach
Research regarding Tumblr was identified. Following a review of the literature, a classification scheme was adapted and applied, to understand research focus. Papers were quantitatively classified using open coded content analysis of method, subject, approach, and topic.

Findings
The majority of published work relating to Tumblr concentrates on conceptual issues, followed by aspects of the messages sent. This has evolved over time. Perceived benefits are the platform’s long-form text posts, ability to track tags, and the multimodal nature of the platform. Severe research limitations are caused by the lack of demographic, geo-spatial, and temporal metadata attached to individual posts, the limited Advanced Programming Interface, restricted access to data, and the large amounts of ephemeral posts on the site.

Research limitations/implications
This study focusses on Tumblr: the applicability of the approach to other media is not considered. The authors focus on published research and conference papers: there will be book content which was not found using the method. Tumblr as a platform has falling user numbers which may be of concern to researchers.

Practical implications
The authors identify practical barriers to research on the Tumblr platform including lack of metadata and access to big data, explaining why Tumblr is not as popular as Twitter in academic studies.

Social implications
This paper highlights the breadth of topics covered by social media researchers, which allows us to understand popular online platforms.

Originality/value
There has not yet been an overarching study to look at the methods and purpose of those who study Tumblr. The authors identify Tumblr-related research papers from the first appearing in 2011 July until 2015 July. The classification derived here provides a framework that can be used to analyse social media research, and in which to position Tumblr-related work, with recommendations on benefits and limitations of the platform for researchers.
N-loop learning: part I – of hedgehog, fox, dodo bird and sphinx
Authors: Simonin Bernard L. 
Published: March 2017

Purpose
This paper aims to encourage greater clarity and stimulate further interest in thorough empirical research in the area of learning levels. The broader motivation here is to urge researchers to not only theorize but also undertake elaborate and much needed empirical work.

Design/methodology/approach
Part I of the study rests on a reflection and review of the literature concerned with “N-loop learning”, that is, the different hierarchical levels and stages of organizational learning.

Findings
The study provides some views and classification schemes on how to reconcile and think about different levels of learning. Some learning archetypes are identified that guide further reflection and elaboration on learning stages and hierarchies.

Originality/value
“N-loop learning” is introduced to encapsulate and systematize a vast array of views, models and levels of organizational learning. From zero learning and single-loop learning to quadruple-loop learning, a series of learning archetypes are presented. The case for a proper and clear nomenclature of learning levels is singled out. Finally, a strong case for empirical testing in this area is advocated.
Skin cancer history, sun‐related attitudes, behaviour and sunburn among renal transplant recipients versus general population
Authors: Leung Vivian Ka Ying , Dobbinson Suzanne Jane , Goodman David Josef , Kanellis John , Chong Alvin Heong 
Published: March 2017

AbstractBackground/ObjectivesRenal transplant recipients (RTR) have both an excessive skin cancer incidence and a high mortality rate. In Australia RTR receive extensive public education on skin cancer and many undergo further education pre/post‐transplant. This study examines whether RTR have sufficiently rigorous sun protection behaviour compared with the general population.MethodsAltogether 179 RTR from two large Melbourne hospitals involving skin clinic teams in patient care were recruited to undergo cross‐sectional telephone interviews. Comparisons were made with residents (25–69 years) surveyed using equivalent measures and methods in adjacent summers (2006–2007, n = 904; 2010–2011, n = 942) for regular population monitoring surveys. Multivariate analyses of weekend behaviour were adjusted for related ambient temperature records.ResultsRTR were more compliant with sun protection behaviour on the weekend prior to interview than the residents surveyed. For example, for 2006–2007 and 2010–2011, the odds ratio and confidence intervals (CI 95%) were respectively: used sunscreen: 2.0 (1.1–3.8) and 2.8 (1.4–5.3); wore a long‐sleeved top: 4.5 (2.4–8.5) and 3.6 (1.9–7.0). RTR sunburn prevalence (5%) appeared similar to that of residents (odds ratios comparing 2006–2007 and 2010–2011 0.6 [95% CI, 0.2–1.6] and 0.7 [95% CI, 0.3–1.9]). Despite generally good sun protection behaviour, many RTR (47%) had skin cancers treated.ConclusionThe intensive education of RTR may have contributed to their better sun protection. Some RTR with excessive exposure to UV radiation introduction of may benefit from implementation of further photoprotection strategies. These findings may be particularly relevant to other RTR groups receiving education about sun protection.
Pigmented onychomatricoma: Four cases
Authors: Ocampo‐Garza Jorge , Di Chiacchio Nilton Gioia , Di Chiacchio Nilton 
Published: March 2017

AbstractOnychomatricoma (OM) presenting as a longitudinal melanonychia is a very uncommon clinical presentation with very few cases in the literature. Our aim in this article is to report four cases of pigmented OM, and describe their clinical and dermoscopic findings and the importance of the differential diagnoses, especially with melanoma.
High serum vitamin D level correlates with better prognostic indicators in primary melanoma: A pilot study
Authors: Lim Alvin , Shayan Ramin , Varigos George 
Published: March 2017

AbstractBackground/ObjectivesSunlight is a major risk factor for cutaneous melanoma. However, its interaction with melanoma is complex. In particular, vitamin D is a UVB‐derived hormone that has been shown to have anti‐cancer effects. In this retrospective pilot study we sought to determine an association between the clinicopathological features of melanoma and the patients’ corresponding serum vitamin D level.MethodsIn total, 109 primary melanomas diagnosed between 2001 and 2013 were retrospectively identified from our institutional database with a corresponding 25‐hydroxyvitamin D3 level estimated within 6 months of diagnosis. Tumour, clinical (age, sex, tumour location) and pathological (thickness, mitosis, ulceration, Clark level, subtype, metastatic status) parameters were correlated with vitamin D. For statistical analysis, an unpaired Student's t‐test and anova was used for categorical variables, and Spearman's correlation for continuous variables.ResultsVitamin D level was inversely associated with Breslow thickness as a dichotomous, categorical and continuous variable. The association remained significant when controlled for patient's age and sex (P = 0.026). Vitamin D was higher in non‐ulcerated tumours compared with ulcerated tumours (P = 0.006) and in tumours with mitotic rate <1/mm2 compared with ≥1/mm2 (P = 0.036). A significant association was found between vitamin D level and tumour histological subtype (P = 0.019). On subgroup analysis, significant associations were found between superficial spreading melanoma (SSM) and nodular melanoma (P = 0.026), and SSM and acral lentiginous melanoma (P = 0.007).ConclusionA high vitamin D status may benefit prognosis in patients diagnosed with primary melanoma. A prospective cohort analysis with a large sample and controlled for other vitamin D confounders would validate these findings.
Dietary fatty acids influence sperm quality and function
Authors: Ferramosca A. , Moscatelli N. , Di Giacomo M. , Zara V. 
Published: March 2017

SummaryRecently, obesity has been linked to male infertility. In animal models the administration of a high‐fat diet caused a reduction in sperm quality, by impairing gamete energy metabolism. The aim of this study was to investigate a possible effect of dietary fatty acids supplementation in the modulation of sperm energy metabolism and, in turn, in the improvement of sperm quality in rats fed a high‐fat diet. Sexually mature male Sprague–Dawley rats were divided into four groups and fed for 4 weeks a standard diet (control group), a high‐fat diet (enriched in 35% of fat and 15% sucrose), a high‐fat diet supplemented with 2.5% olive oil (a source of monounsaturated fatty acids) or a high‐fat diet supplemented with 2.5% krill oil (a source of n‐3 polyunsaturated fatty acids). Liver and adipose tissue weight, plasma glucose, insulin and lipid concentrations were determined. Activities of enzymes involved in sperm energetic metabolism were evaluated by spectrophotometric assays. Sperm mitochondrial respiratory efficiency was also assayed. The obtained results suggest that olive oil partially counteracts the negative effects of a high‐fat diet on sperm quality, by increasing gamete motility, by reducing oxidative stress and slightly improving mitochondrial respiration efficiency. On the other hand, krill oil determines an increase in sperm concentration and motility, an increase in the activities of lactate dehydrogenase, Krebs cycle enzymes and respiratory chain complexes; a parallel increase in the cellular levels of ATP and a reduction in oxidative damage were also observed. These results suggest that dietary fatty acids are able to positively influence sperm quality and function.
The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system
Authors: Kietzmann Thomas , Petry Andreas , Shvetsova Antonina , Gerhold Joachim M , Görlach Agnes 
Published: March 2017

Cardiovascular diseases are among the leading causes of death worldwide. Reactive oxygen species (ROS) can act as damaging molecules but also represent central hubs in cellular signalling networks. Increasing evidence indicates that ROS play an important role in the pathogenesis of cardiovascular diseases, although the underlying mechanisms and consequences of pathophysiologically elevated ROS in the cardiovascular system are still not completely resolved. More recently, alterations of the epigenetic landscape, which can affect DNA methylation, post‐translational histone modifications, ATP‐dependent alterations to chromatin and non‐coding RNA transcripts, have been considered to be of increasing importance in the pathogenesis of cardiovascular diseases. While it has long been accepted that epigenetic changes are imprinted during development or even inherited and are not changed after reaching the lineage‐specific expression profile, it becomes more and more clear that epigenetic modifications are highly dynamic. Thus, they might provide an important link between the actions of ROS and cardiovascular diseases. This review will provide an overview of the role of ROS in modulating the epigenetic landscape in the context of the cardiovascular system.Linked ArticlesThis article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc
The impact of resettlement on Karen refugee family relationships: A qualitative exploration
Authors: McCleary Jennifer Simmelink 
Published: March 2017

AbstractRefugee resettlement policy in the United States prioritizes family reunification, meaning, resettling families that may have been separated for years are reuniting and reestablishing connections while integrating into a new culture. Scholarship on the impact of resettlement and integration has focused primarily on the individual level, despite evidence that strong family relationships are a documented protective factor for refugee families. This paper aims to explore the impact of resettlement on Karen refugee families' relationships. Data from 6 focus groups with 36 Karen refugee community members and interviews with 8 key stakeholders suggests that refugee families are at risk of a constellation of relational issues that are exacerbated by the stress of resettlement. Data also indicates that families have indigenous strategies for solving problems that could be harnessed to develop culturally relevant family support services.