bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detector Sampling of Optical/IR Spectra: How Many Pixels per FWHM?
Authors: Robertson J. Gordon 
Published: August 2017

AbstractMost optical and IR spectra are now acquired using detectors with finite-width pixels in a square array. Each pixel records the received intensity integrated over its own area, and pixels are separated by the array pitch. This paper examines the effects of such pixellation, using computed simulations to illustrate the effects which most concern the astronomer end-user. It is shown that coarse sampling increases the random noise errors in wavelength by typically 10–20 % at 2 pixels per Full Width at Half Maximum, but with wide variation depending on the functional form of the instrumental Line Spread Function (i.e. the instrumental response to a monochromatic input) and on the pixel phase. If line widths are determined, they are even more strongly affected at low sampling frequencies. However, the noise in fitted peak amplitudes is minimally affected by pixellation, with increases less than about 5%. Pixellation has a substantial but complex effect on the ability to see a relative minimum between two closely spaced peaks (or relative maximum between two absorption lines). The consistent scale of resolving power presented by Robertson to overcome the inadequacy of the Full Width at Half Maximum as a resolution measure is here extended to cover pixellated spectra. The systematic bias errors in wavelength introduced by pixellation, independent of signal/noise ratio, are examined. While they may be negligible for smooth well-sampled symmetric Line Spread Functions, they are very sensitive to asymmetry and high spatial frequency sub-structure. The Modulation Transfer Function for sampled data is shown to give a useful indication of the extent of improperly sampled signal in an Line Spread Function. The common maxim that 2 pixels per Full Width at Half Maximum is the Nyquist limit is incorrect and most Line Spread Functions will exhibit some aliasing at this sample frequency. While 2 pixels per Full Width at Half Maximum is nevertheless often an acceptable minimum for moderate signal/noise work, it is preferable to carry out simulations for any actual or proposed Line Spread Function to find the effects of various sampling frequencies. Where spectrograph end-users have a choice of sampling frequencies, through on-chip binning and/or spectrograph configurations, it is desirable that the instrument user manual should include an examination of the effects of the various choices.
Relationships between the Sakarya Zone and the Ankara–Erzincan suture (central-northern Turkey): geological and petrographic data from the Ankara–Çankiri, Çorum and Amasya areas
Authors: PANDELI ENRICO , ELTER FRANCO MARCO , TOKSOY-KÖKSAL FATMA , PRINCIPI GIANFRANCO , ORLANDO ANDREA , VALLERI GIGLIOLA , GIUSTI RICCARDO , ORTI LETIZIA 
Published: August 2017

AbstractThe study was performed in central-northern Anatolia (from Ankara to Amasya) to investigate the relationships of the Sakarya Zone units and the Izmir–Ankara–Erzincan suture (IAES) melange. It reveals that all the Sakarya Zone units are metamorphic and three main tectonostratigraphic units have been distinguished for the first time: the BAA (metasiliciclastic rocks capped by metacarbonates and varicoloured phyllite), the BKC (poly-metamorphic garnet-bearing micaschist and metabasite with a well-preserved relict HP–LT amphibole in a low-amphibolitic to greenschist-facies framework) and the AMC (meta-arkose passing vertically to carbonate–phyllitic alternations and, then, to a thick succession of prevailing acidic to intermediate–basic metavolcanites and volcanic-rich metasediments). The BAA and AMC, whose metamorphic frameworks are of Cimmerian age, underlie the Mesozoic carbonate cover sequences (e.g. t2-3, j3–k1) that often show tectonic detachments and slicing. The piling up of the BAA above the HP–LT BKC can be correlated to the tectonic superposition of two similar units (i.e. the Cimmerian Çangaldağ Complex and the Alpine Middle–Upper Cretaceous Domuzdağ Complex, respectively) defined by previous authors in other sectors of the Central Pontides front. The ophiolitic melange generally underlies the Sakarya Zone, but locally (e.g. SE of Amasya) tectonically rests above the latter, probably owing to back-thrusting that occurred during the Tertiary syn-collisional shortenings and the later strike-slip tectonics. We hypothesize that, also in these areas, the Sakarya Zone–IAES consists of a complex tectonic stack of different units, belonging to different palaeogeographic domains and orogenic events (Cimmerian versus Alpine orogenies), but originated within a single long-lived (since Late Triassic to Paleocene/Eocene times), prograding subduction–accretion system in front of the Laurasian continent.
Learning Western Techniques of Empire: Republican China and the New Legal Framework for Managing Tibet
Authors: CARRAI MARIA ADELE 
Published: August 2017

AbstractAt the end of the nineteenth century, China found itself torn between its imperial past and its nation-state future. By the time it became a Republic in 1911, China had to redefine its territory in new national sovereign terms. Until then its territory had been inscribed in more malleable frontiers and boundaries within the normative framework of the so-called ‘tribute system’. The article shows how, applying the new legal techniques of empire learned from the West, the Chinese central government, wherever possible, attempted to expand its new sovereign domain in territories like Tibet, Xinjiang, and Mongolia, where, according to international law, all the prerequisites existed for national self-determination and independence. In the context of opposing British and Tibetan claims, the Chinese appropriation of international law in the Republican period (1911–1949) helped China not only to assert itself in the international domain as a sovereign state, defending itself against Western imperialism, but also to pursue its own fictional imperial claims over Tibet, without which the Communists’ ‘liberation’ of Tibet would have not been possible. The paper highlights the interplay of imperial techniques based on international law, the relativity of this legal language, and how the strategies of empire are not only a prerogative of the West, but can be quickly adopted by those who have been subjected to them, resulting in a vicious circle.
Identifying transmission routes of Streptococcus pneumoniae and sources of acquisitions in high transmission communities
Authors: ALTHOUSE B. M. , HAMMITT L. L. , GRANT L. , WAGNER B. G. , REID R. , LARZELERE-HINTON F. , WEATHERHOLTZ R. , KLUGMAN K. P. , RODGERS G. L. , O'BRIEN K. L. , HU H. 
Published: August 2017

AbstractIdentifying the transmission sources and reservoirs of Streptococcus pneumoniae (SP) is a long-standing question for pneumococcal epidemiology, transmission dynamics, and vaccine policy. Here we use serotype to identify SP transmission and examine acquisitions (in the same household, local community, and county, or of unidentified origin) in a longitudinal cohort of children and adults from the Navajo Nation and the White Mountain Apache American Indian Tribes. We found that adults acquire SP relatively more in the household than other age groups, and children 2–8 years old typically acquire in their own or surrounding communities. Age-specific transmission probability matrices show that transmissions within household were mostly seen from older to younger siblings. Outside the household, children most often transmit to other children in the same age group, showing age-assortative mixing behavior. We find toddlers and older children to be most involved in SP transmission and acquisition, indicating their role as key drivers of SP epidemiology. Although infants have high carriage prevalence, they do not play a central role in transmission of SP compared with toddlers and older children. Our results are relevant to inform alternative pneumococcal conjugate vaccine dosing strategies and analytic efforts to inform optimization of vaccine programs, as well as assessing the transmission dynamics of pathogens transmitted by close contact in general.
Children with hypoplastic left heart syndrome have lower quality of life than healthy controls and children with other illnesses
Authors: Dempster Nicole , Cua Clifford L , Wernovsky Gil , Caris Elizabeth , Neely Trent , Allen Robin , Butz Catherine 
Published: August 2017

AbstractObjectivePrevious studies suggest that children with congenital cardiac diagnoses report lower quality of life when compared with healthy norms. A few studies have evaluated quality of life specifically in children born with hypoplastic left heart syndrome, a condition requiring several surgeries before age three. The aim of this study was to use an empirically validated and standardised measure – the Pediatric Quality of Life Inventory – to evaluate quality of life in children with hypoplastic left heart syndrome and compare the findings with similar, medically complicated samples.MethodsThe parent-report Pediatric Quality of Life Inventory was administered, and demographic information was collected through an internet portal. A total of 121 caregivers of children with hypoplastic left heart syndrome responded. The sample included children aged 2–18 years (M=10.81 years). Independent sample t-tests were used to compare our sample with published norms of healthy children and children with acute or chronic illnesses.ResultsChildren with hypoplastic left heart syndrome were rated as having significantly lower overall quality-of-life scores (M=59.69) compared with published norms of children without medical diagnoses (M=83.00) and those with acute (M=78.70) or chronic (M=77.19) illnesses (p<0.001). Children with hypoplastic left heart syndrome complicated by a stroke or seizure (15%) reported the lowest quality of life. The results held for all subscales (p<0.001).ConclusionsChildren with hypoplastic left heart syndrome appear to be a significantly vulnerable population with difficulties in functioning across psychosocial domains and across the age span. Further research is required to facilitate early identification of the need for resources for these children and families, especially for children who experience additional medical complications.
Giant coronary artery aneurysms complicating Kawasaki disease in Mexican children
Authors: Garrido-García Luis M. , Morán-Villaseñor Edna , Yamazaki-Nakashimada Marco A. , Cravioto Patricia , Galván Fernando 
Published: August 2017

AbstractBackgroundOne of the most important complications of Kawasaki disease is the development of giant coronary aneurysms. Risk factors for their development are still not clear.MethodsA retrospective analysis was conducted at the National Institute of Paediatrics in Mexico City, Mexico. It included all patients with a diagnosis of acute Kawasaki disease between August, 1995 and August, 2015. Clinical and laboratory findings, as well as echocardiographic measurements, were recorded. Patients with giant coronary aneurysms (z-score⩾10) were compared with the rest of the patients. A value of p<0.05 was considered statistically significant. Odds ratios and their 95% confidence intervals were calculated to define risk factors.ResultsDuring the study period, 416 patients were diagnosed with Kawasaki disease. Of them, 34 developed giant coronary aneurysms during the acute stage of the disease. In the multivariate analysis, patients younger than 1 year, those with a higher duration of illness at the time of diagnosis, and those who received additional intravenous immunoglobulin showed a significantly higher frequency of giant coronary aneurysms.ConclusionsOne of the main factors associated with the development of giant coronary aneurysms was the delay in the diagnosis of Kawasaki disease. This finding highlights the importance of maintaining a high suspicion of the disease, which would enable an early diagnosis and prompt treatment and decrease the risk for developing giant coronary aneurysms.
Premature ventricular contractions as a side effect of filgrastim in a child with B-thalassaemia
Authors: Nazir Hanan F. , Joshi Niranjan , Wali Yasser A. 
Published: August 2017

AbstractPremature ventricular contractions are a rare side effect of filgrastim, reported mainly in elderly men. Here we report the case of a 9-year-old child with thalassaemia who developed frequent premature ventricular contractions after three doses of filgrastim were given for deferiprone-induced agranulocytosis. The arrhythmia resolved 3 weeks after discontinuation of filgrastim. Children treated with filgrastim should be carefully monitored for potentially serious arrhythmia.
The effect of tax withholding on pre-retirement savings withdrawals: evidence from Canada
Authors: MESSACAR DEREK 
Published: August 2017

AbstractThis study assesses the effect of tax withholding on pre-retirement withdrawals from a tax-preferred savings account in Canada. Using a large sample of administrative tax records and exploiting inter-provincial variation in tax withholding rates over time in the identification, the withdrawal elasticity to the net-of-tax withholding rate is estimated to be approximately 0.40 for many prime-aged savers. Hence, tax withholding discourages pre-retirement savings withdrawals and serves as a de facto savings commitment device. This finding is not well-explained by rational agency, and theories of present-biased time preferences and fiscal illusion are shown to be a better explanation of such behavior.
Hospitalitas: Barbarian settlements and constitutional foundations of medieval Europe
Authors: YOUNG ANDREW T. 
Published: August 2017

AbstractA rough balance of political power between monarchs and a militarized landed aristocracy characterized medieval Western Europe. Scholars have argued that this balance of power contributed to a tradition of limited government and constitutional bargaining. I argue that 5th- and 6th-century barbarian settlements created a foundation for this balance of power. The settlements provided barbarians with allotments of lands or taxes due from the lands. The allotments served to align the incentives of barbarian warriors and Roman landowners, and realign the incentives of barbarian warriors and their leadership elite. Barbarian military forces became decentralized and the warriors became political powerful shareholders of the realm.
Asymptotic tail behaviour of phase-type scale mixture distributions
Authors: Rojas-Nandayapa Leonardo , Xie Wangyue 
Published: August 2017

AbstractWe consider phase-type scale mixture distributions which correspond to distributions of a product of two independent random variables: a phase-type random variable Y and a non-negative but otherwise arbitrary random variable S called the scaling random variable. We investigate conditions for such a class of distributions to be either light- or heavy-tailed, we explore subexponentiality and determine their maximum domains of attraction. Particular focus is given to phase-type scale mixture distributions where the scaling random variable S has discrete support – such a class of distributions has been recently used in risk applications to approximate heavy-tailed distributions. Our results are complemented with several examples.
ACTION TYPES IN STIT SEMANTICS
Authors: HORTY JOHN , PACUIT ERIC 
Published: August 2017

AbstractStit semantics grows out of a modal tradition in the logic of action that concentrates on an operator representing the agency of an individual in seeing to it that some state of affairs holds, rather than on the actions the individual performs in doing so. The purpose of this paper is to enrich stit semantics, and especially epistemic stit semantics, by supplementing the overall framework with an explicit treatment of action types. We show how the introduction of these new action types allows us to define a modal operator capturing an epistemic sense of agency, and how this operator can be used to express an epistemic sense of ability.
Misalignment with the external light environment drives metabolic and cardiac dysfunction
Authors: West Alexander C. , Smith Laura , Ray David W. , Loudon Andrew S. I. , Brown Timothy M. , Bechtold David A. 
Published: August 2017

AbstractMost organisms use internal biological clocks to match behavioural and physiological processes to specific phases of the day–night cycle. Central to this is the synchronisation of internal processes across multiple organ systems. Environmental desynchrony (e.g. shift work) profoundly impacts human health, increasing cardiovascular disease and diabetes risk, yet the underlying mechanisms remain unclear. Here, we characterise the impact of desynchrony between the internal clock and the external light–dark (LD) cycle on mammalian physiology. We reveal that even under stable LD environments, phase misalignment has a profound effect, with decreased metabolic efficiency and disrupted cardiac function including prolonged QT interval duration. Importantly, physiological dysfunction is not driven by disrupted core clock function, nor by an internal desynchrony between organs, but rather the altered phase relationship between the internal clockwork and the external environment. We suggest phase misalignment as a major driver of pathologies associated with shift work, chronotype and social jetlag.
Higher-order assembly of crystalline cylindrical micelles into membrane-extendable colloidosomes
Authors: Dou Hongjing , Li Mei , Qiao Yan , Harniman Robert , Li Xiaoyu , Boott Charlotte E. , Mann Stephen , Manners Ian 
Published: August 2017

AbstractCrystallization-driven self-assembly of diblock copolymers into cylindrical micelles of controlled length has emerged as a promising approach to the fabrication of functional nanoscale objects with high shape anisotropy. Here we show the preparation of a series of crystallizable diblock copolymers with appropriate wettability and chemical reactivity, and demonstrate their self-assembly into size-specific cylindrical micelle building blocks for the hierarchical construction of mechanically robust colloidosomes with a range of membrane textures, surface chemistries and optical properties. The colloidosomes can be structurally elaborated post assembly by in situ epitaxial elongation of the membrane building blocks to produce microcapsules covered in a chemically distinct, dense network of hair-like outgrowths. Our approach provides a route to hierarchically ordered colloidosomes that retain the intrinsic growth activity of their constituent building blocks to permit biofunctionalization, and have potential applications in areas such as biomimetic encapsulation, drug delivery, catalysis and biosensing.
Attempts to replicate genetic associations with schizophrenia in a cohort from north India
Authors: Prasad Suman , Bhatia Triptish , Kukshal Prachi , Nimgaonkar Vishwajit L. , Deshpande Smita N. , Thelma B. K. 
Published: August 2017

AbstractSchizophrenia is a chronic, severe, heritable disorder. Genome-wide association studies, conducted predominantly among Caucasians, have indicated > 100 risk alleles, with most significant SNPs on chromosome 6. There is growing interest as to whether these risk alleles are relevant in other ethnic groups as well. Neither an Indian genome-wide association studies nor a systematic replication of GWAS findings from other populations are reported. Thus, we analyzed 32 SNPs, including those associated in the Caucasian ancestry GWAS and other candidate gene studies, in a north Indian schizophrenia cohort (n = 1009 patients; n = 1029 controls) using a Sequenom mass array. Cognitive functioning was also assessed using the Hindi version of the Penn Computerized Neuropsychological Battery in a subset of the sample. MICB (rs6916394) a previously noted Caucasian candidate, was associated with schizophrenia at the p = 0.02 level. One SNP, rs2064430, AHI1 (6q23.3, SZ Gene database SNP) was associated at the p = 0.04 level. Other candidates had even less significance with rs6932590, intergenic (p = 0.07); rs3130615, MICB (p = 0.08); rs6916921, NFKBIL1 (p = 0.08) and rs9273012, HLA-DQA1 (p = 0.06) and haplotypic associations (p = 0.01–0.05) of 6p SNPs were detected. Of note, nominally significant associations with cognitive variables were identified, after covarying for age and diagnostic status. SNPs with p < 0.01 were: rs3130375, with working memory (p = 0.007); rs377763, with sensorimotor (p = 0.004); rs6916921, NFKBIL1 with emotion (p = 0.01). This relative lack of significant positive associations is likely influenced by the sample size and/or differences in the genetic architecture of schizophrenia across populations, encouraging population specific studies to identify shared and unique genetic risk factors for schizophrenia.
Long-distance impact of Iceland plume on Norway’s rifted margin
Authors: Koptev Alexander , Cloetingh Sierd , Burov Evgueni , François Thomas , Gerya Taras 
Published: August 2017

AbstractResults of a 3D modeling study inspired by recent seismic tomography of the Northern Atlantic mantle suggest that a complex pattern of hot mantle distribution with long horizontal flows originating from the Iceland mantle plume has been the norm in the geological past. In the Northern Atlantic the Iceland plume has a strong long-distance impact on intraplate deformation affecting both onshore and offshore parts of Norway’s rifted margin. As a result, this margin is characterized by large magnitude differential topography sustained over at least several tens of Myr. Here we use high-resolution 3D thermo-mechanical modeling to demonstrate that the long-distance plume impact can be explained by its fast lateral propagation controlled by pre-existing lithosphere structures. Numerical models show that these structures strongly affect the style of horizontal flow of plume head material. This results in long-distance propagation of hot material emplaced at the lithosphere-asthenosphere boundary causing long-wavelength anomalies in onshore topography of Norway’s rifted margin. Short-wavelength offshore topographic domes are likely caused by joint occurrence of plume-related thermal perturbations and gravitational forces related to plate thickening (ridge push). Our 3D modeling brings together plume impingement, spreading ridge dynamics, and the formation of anomalous intraplate structures offshore Norway in one scenario.
Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy
Authors: Georgakopoulos Nikolaos D. , Frison Michele , Alvarez Maria Soledad , Bertrand Hélène , Wells Geoff , Campanella Michelangelo 
Published: August 2017

AbstractMitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis. We previously identified a novel chemical tool (hereafter referred to as PMI), which drives mitochondria into autophagy without collapsing their membrane potential (ΔΨm). PMI is an inhibitor of the protein-protein interaction (PPI) between the transcription factor Nrf2 and its negative regulator, Keap1 and is able to up-regulate the expression of autophagy-associated proteins, including p62/SQSTM1. Here we show that PMI promotes mitochondrial respiration, leading to a superoxide-dependent activation of mitophagy. Structurally distinct Keap1-Nrf2 PPI inhibitors promote mitochondrial turnover, while covalent Keap1 modifiers, including sulforaphane (SFN) and dimethyl fumarate (DMF), are unable to induce a similar response. Additionally, we demonstrate that SFN reverses the effects of PMI in co-treated cells by reducing the accumulation of p62 in mitochondria and subsequently limiting their autophagic degradation. This study highlights the unique features of Keap1-Nrf2 PPI inhibitors as inducers of mitophagy and their potential as pharmacological agents for the treatment of pathological conditions characterized by impaired mitochondrial quality control.