bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change impact on hydropower generation and adaptation through reservoir operation in a Himalayan river, Tamor
Authors: Khatri Dickembs , Pandey Vishnu Prasad , Lamsal Girish Raj , Baniya Rupesh 
Published: September 2024

ABSTRACT

Integrated assessment of climate change impact and water resource development scenario is crucial for planning and management. In the Himalayan river basin, it is of utmost importance considering the vulnerability to climate change and the pace of water resource development. This study focused on Tamor river basin (TRB), investigating the impacts of climate change on the energy generation from hydropower projects and analyzes the adaptation through reservoir operation. Analyzing the three run-of-river (RoR) hydropower projects and a storage project, this study projects future energy generation. Results showed that RoR is highly susceptible to the impacts, demonstrated by significant reduction during pre-monsoon up to -53% and increment at annual scale up to 28%. In Tamor storage project, the particle-swarm optimization approach generated operational strategies according to altered streamflow conditions. This resulted in adaptation to the projected decrease in March-June flow through flexible operation rules, yielding positive impact on energy generation (up to +7.3% on an annual scale). The new set of rules will adapt to the flow deficit and increase the dry season flow downstream, almost by double than the historical baseline. This research highlights the significance of reservoir project and its optimized operation in effectively managing water under changing climate.
Environmental factors associated with Oncomelania hupensis lindoensis snails in a schistosomiasis-endemic area in Napu, Central Sulawesi
Authors: Koraag Meiske Elisabeth , Octaviani Octaviani , Massie Roy G. A. , Senewe Felly Philipus , Djohan Djohan 
Published: September 2024

ABSTRACT

The presence of the freshwater snail Oncomelania hupensis lindoensis in their habitats is influenced by abiotic environmental factors (nutrients, water salinity, and predators) that play a crucial role in maintaining snail survival. The objective of this study is to determine the relationship between environmental factors and the presence of O. hupensis lindoensis snails in the Napu Valley, one of the Schistosomiasis-endemic areas in Indonesia. Eight environmental factors were measured in three different habitats: a seepage, a ditch, and a pond. The study found O. hupensis lindoensis snails in all three habitats, with significant differences in their numbers (p &lt; 0.05). The seepage habitat had the highest snail density (762.22 snails per m2) compared to the other habitats. Phosphorus levels were highest in the seepage habitat compared to the other habitats, while nitrogen levels were highest in the pond habitat. Pearson correlation analysis found a significant positive correlation between O. hupensis lindoensis snails and water salinity in the ditch habitat (p &lt; 0.05). In addition to environmental factors, the presence of snails can also be influenced by other factors, such as the presence of snail predators, the presence of snail nutrients, and the population of snail host niche competitors.
Assessment of process water quality (depending on the presence of process water systems) in car wash facilities across Germany and the Netherlands
Authors: Löffler Richard , Evers Holger , Beyer Andreas 
Published: September 2024

ABSTRACT
There are around 2,500 car wash lines in Germany, consuming around 30 million m3 of drinking water per year. In view of the increasing scarcity of water, this level of consumption could soon be restricted by law, as it is in some countries. There are only a few systematic studies on process water systems in car wash lines in Middle Europe; we therefore carried out a survey to determine process water quality parameters (COD, turbidity, water hardness, pH, conductivity, dissolved O2, and temperature). Data were collected and analysed from 63 different locations in Germany and the Netherlands. In addition, longitudinal parameters were measured for 1 year at a single state-of-the-art site in Germany. The scatter of the observed values was quite considerable. The average COD in water of car wash sites with biological treatment was found to be significantly lower than in car wash sites working with filter treatment. Overall, the deviation of the pollution parameters was higher than expected. Surprisingly, there is hardly any reliable data on freshwater consumption in the car wash facilities. As most of the long-established facilities do not have a modern water treatment system, freshwater consumption is up to 300 L per car washed.
Epitranscriptome: A Novel Regulatory Layer during Atherosclerosis Progression
Authors: Schiano Concetta , Trama Ugo , Coscioni Enrico , Infante Teresa , Coppola Annapaola , de Nigris Filomena , Napoli Claudio 
Published: September 2024

Abstract:
RNA modifications have recently gained great attention due to their extensive
regulatory effects in a wide range of cellular networks and signaling pathways. In cardiovascular
diseases (CVDs), several RNA changes, called “epitranscriptome” alterations,
are found in all RNA molecules (tRNA, rRNA, mRNA, and ncRNAs). Unlike the epigenetic
process, which influences the progression of atherosclerosis (AS), its transcriptional
and post-transcriptional regulatory mechanisms are still unknown. Here, we described
the main epitranscriptome signs to provide new insights into AS, including m6A, m5C,
m1A, m7G, Ψ, and A-to-I editing. Moreover, we also included all current known RNA--
modifier-targeting, including small molecular inhibitors or activators, mainly designed
against m6A- and m5A-related enzymes, such as METTL3, FTO, and ALKBH5. Finally,
since only a few drugs, such as azacitidine and tazemetostat, targeting the DNA
epigenome, have been approved by the FDA, the next challenge would be to identify
molecules for targeting the RNA epitranscriptome. To date, total Panax notoginseng total
saponin could reduce vascular hyperplasia via Wilms’ tumor-associated protein-1
m6A-dependent. Indeed, a virtual screening allowed us to individuate a phytomolecule,
the rhein, which acts as an FTO inhibitor by increasing mRNA m6A levels. In this review,
we highlighted the RNA epitranscriptome pathways implicated in AS, describing
their biological functions and their connections to the disease. The identification of epitranscriptome-
sensitive pathways could provide novel opportunities to find predictive,
diagnostic, and prognostic biomarkers for precision medicine.
Beyond Conventional: Nanotechnology-Driven Herbal Interventions in the Treatment of Polycystic Ovary Syndrome
Authors: Roy Monalisa , Mazumder Rupa , Singh Neelam , Bhardwaj Snigdha , Mishra Rakhi , Mishra Rashmi , Kumar Bimlesh 
Published: September 2024

Objective:
In patients with PCOS, oxidative stress is caused by an imbalance between
antioxidants and reactive oxygen species, which increases the risk of cardiovascular disease. Existing
therapies, which mostly include synthetic medications, often result in serious adverse effects.
Alternatively, a secure and efficient method of treating PCOS appears to be the mix of phytoconstituents
and lifestyle changes.

Methods:
This review examines the global impact of PCOS, a prevalent hormonal disorder combining
genetic, environmental, behavioral, and endocrine factors, and the potential side effects of
synthetic medications used for its treatment. The authors conducted a narrative review using major
databases like PubMed, ScienceDirect, and Google Scholar from October 1st to November
25th, 2023. They analyzed data from review articles, research articles, and meta-analyses published
until August 2023 on pathogenesis, diagnosis, management, synthetic and herbal treatment,
and nanotechnology effective in PCOS treatment, including those related to the theme.

Results:
PCOS affects women globally, and synthetic agents like insulin sensitizers, contraceptive
pills, and anti-androgens may have numerous long-term health effects. A natural substitute for contemporary
pharmaceuticals, herbal therapies are prized for their health benefits. Scientific studies
support the safety and effectiveness of herbal bio-actives, which utilize diverse phytochemicals to
reduce PCOS symptoms.

Conclusion:
To overcome the side effects of the synthetic agents, more influence is given to the
natural way of curbing the syndrome for a healthier life. Thus, this review combines the potential
advantages of utilizing various herbal plants for PCOS treatment by amalgamating findings from
numerous literature studies.
Effect of Chrysin and Chrysin Nanocrystals on Chlorpyrifos-Induced Dysfunction of the Hypothalamic-Pituitary-Testicular Axis in Rats
Authors: Farkhondeh Tahereh , Roshanravan Babak , Samini Fariborz , Samarghandian Saeed 
Published: September 2024

Aims and Background:
The escalating global concerns regarding reproductive health underscore the urgency of investigating the impact of environmental pollutants on
fertility. This study aims to focus on Chlorpyrifos (CPF), a widely-used organophosphate insecticide, and explores its adverse influence on the
hypothalamic-pituitary-testicular axis in Wistar male rats. This study explores the potential protective effects of chrysin nanocrystal (CHN), a
flavonoid with known antioxidant and anti-inflammatory properties, against CPF-induced impairments in male Wistar rats.

Methods:
Chrysin nanocrystals were prepared using a solvent precipitation method. Six sets of male Wistar rats were subjected to 30 days of treatment,
comprising a control group, a group treated solely with CPF, groups treated with CHN at doses of 5 mg/kg and 10 mg/kg, and groups co-treated
with CPF and CHN. Serum levels of reproductive hormones, enzyme biomarkers of testicular function, oxidative stress, and inflammatory
biomarkers were assessed. Additionally, histological examinations were conducted on the hypothalamus, testes, and epididymis.

Results:
CHN exhibited antioxidant and anti-inflammatory properties, effectively counteracting CPF-induced reductions in Luteinizing Hormone (LH),
serum testosterone, Follicle-Stimulating Hormone (FSH), and testicular enzyme biomarkers. Moreover, CHN enhanced antioxidant defenses, as
evidenced by decreased malondialdehyde (MDA) and increased glutathione (GSH) levels in the hypothalamus, and testes, epididymis.
Inflammatory markers, including nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), were significantly reduced in
CHN co-treated groups compared to the CPF-only group. Histopathological analyses confirmed the protective effects of CHN on tissue integrity

Conclusion:
Chrysin nanocrystal demonstrated promising potential in mitigating CPF-induced reproductive deficits in male rats through its anti-inflammatory
and antioxidant properties. This study provides valuable insights into therapeutic interventions against environmental toxin-induced reproductive
toxicity, emphasizing the potential of chrysin nanocrystals as a protective agent in the context of CPF exposure
Role of Plant-derived Bioactive Compounds in Potential Snakebite Envenoming: A Review
Authors: Mohanraj Subramanian , Saravanakumar Arthanari , Periyasamy Parthiban , Kumar Chinnaiyan Santhosh , Vijayan Nivedha , Jambulingaeswaran Vinodha , Murugan Kokila 
Published: September 2024

:
The issue of snakebite continues to be a distinctive matter of public health in various
regions across the globe, with a particular emphasis on India, where the ailment is widely prevalent.
Snakebites in the country disproportionately affect rural and indigenous populations, resulting
in some of the highest morbidity and mortality rates worldwide. Regrettably, in numerous
tropical nations, the accessibility of antivenom is frequently postponed or restricted, thereby
rendering antiserum the only targeted therapeutic alternative. Nevertheless, administering antiserum
in isolation does not provide adequate safeguard against the adverse effects of venomtriggered
hypersensitivity complications, which may be grave. Hence, this study aims to review
the plant-derived bioactive compounds used to treat snakebites in India. This review compiles
a list of medicinal plants and plant-derived bioactive compounds used in treating snakebites in
India, which were reviewed from the available literature in public databases (PubMed, Science
Direct, Springer, and Scopus). Search words used were 'bioactive compounds,' 'treatment for a
snakebite,' 'antivenom and snakebite,' 'Medicinal plants for snakebite, and 'composition of
snake venom'.

:
A list of 200 medicinal plants traditionally used in several countries for treating snake bites was
obtained. Based on scientific data, we reviewed only 83 medicinal plant extracts and bioactive
compounds obtained from various families, tested under in-vivo and in-vitro conditions to determine
their neutralization potency of snakebite envenomation. In this article, we have presented
a comprehensive review, judgmentally analyzed medicinal plants and their bioactive
compounds for their therapeutic potential against snake envenomation, and offer a thorough
discourse on diverse herbal plants employed globally for managing snakebites.
KOMPARASI KETAHANAN BANK SYARIAH DAN BANK KONVENSIONAL SELAMA PANDEMI COVID-19: ANALISIS INDEX BANKING CRISIS
Authors: Anisa Cindy Arzamitha  , Munawar Ismail  
Published: September 2024

This study aims to compare the resilience of Islamic and conventional banking during the COVID-19 pandemic. Banking resilience is measured by the Banking Crisis Index (IBC) which is compiled using five components, namely Non Performing Loan (NPL)/Non Permorming Financing (NPL), Loan to Deposit Ratio (LDR)/ Financing to Deposit Ratio (FDR), Biaya Operasi Pendapatan Operasi (BOPO), Capital Adequacy Ratio (CAR), dan Return on Assets (ROA). The data used was obtained from monthly reports on Indonesian banking statistics from 2020-2022 which were then analyzed using a Mann Whitney U-Test. The result of this study indicate that there are significant differences in the resilience of islamic and conventional banking during COVID-19 with a significance value of 0,000>0,05.
Pengaruh Perceived Value, Brand Image, Dan Service Quality Terhadap Loyalitas Konsumen
Authors: Denelsky Clementhio , Hussein Ananda Sabil 
Published: September 2024

The growth of the ice cream industry resulted in intense competition in the industry. This research was conducted with the aim of identifying the impact and relationship between perceived value, brand image, and service quality on consumer loyalty in Mixue. The writer is interested in examining the effect partially. This research is included in the category of explanatory research which aims to explain the causal relationship between the variables studied through hypothesis testing. The sampling method used is non-probability sampling using a purposive sampling method, in which respondents must be at least 17 years old and have purchased products at Mixue outlets in Malang City. Data analysis in this study was carried out using the SPSS 24 application (Statistical Package for the Social Sciences) to perform multiple linear regression testing.

Abstrak
Pertumbuhan industri es krim mengakibatkan ketatnya persaingan pada industri tersebut. Penelitian ini dilakukan dengan tujuan untuk mengidentifikasi dampak dan hubungan antara perceived value, brand image, dan service quality terhadap loyalitas konsumen di Mixue. Penulis tertarik untuk meneliti pengaruh secara parsial. Penelitian ini termasuk dalam kategori penelitian eksplanatori yang bertujuan menjelaskan hubungan sebab-akibat antara variabel yang diteliti melalui pengujian hipotesis. Metode sampling yang digunakan adalah non probability sampling dengan menggunakan metode purposive sampling, di mana responden harus berusia minimal 17 tahun dan pernah melakukan pembelian produk di gerai Mixue di Kota Malang. Analisis data dalam penelitian ini dilakukan menggunakan aplikasi SPSS 24 (Statistical Package for the Social Sciences) untuk melakukan pengujian regresi linear berganda.
Reinforcement Learning to Optimize Ventilator Settings for Patients on Invasive Mechanical Ventilation: Retrospective Study
Authors: Liu Siqi , Xu Qianyi , Xu Zhuoyang , Liu Zhuo , Sun Xingzhi , Xie Guotong , Feng Mengling , See Kay Choong 
Published: September 2024

Background
One of the significant changes in intensive care medicine over the past 2 decades is the acknowledgment that improper mechanical ventilation settings substantially contribute to pulmonary injury in critically ill patients. Artificial intelligence (AI) solutions can optimize mechanical ventilation settings in intensive care units (ICUs) and improve patient outcomes. Specifically, machine learning algorithms can be trained on large datasets of patient information and mechanical ventilation settings. These algorithms can then predict patient responses to different ventilation strategies and suggest personalized ventilation settings for individual patients.

Objective
In this study, we aimed to design and evaluate an AI solution that could tailor an optimal ventilator strategy for each critically ill patient who requires mechanical ventilation.

Methods
We proposed a reinforcement learning–based AI solution using observational data from multiple ICUs in the United States. The primary outcome was hospital mortality. Secondary outcomes were the proportion of optimal oxygen saturation and the proportion of optimal mean arterial blood pressure. We trained our AI agent to recommend low, medium, and high levels of 3 ventilator settings—positive end-expiratory pressure, fraction of inspired oxygen, and ideal body weight–adjusted tidal volume—according to patients’ health conditions. We defined a policy as rules guiding ventilator setting changes given specific clinical scenarios. Off-policy evaluation metrics were applied to evaluate the AI policy.

Results
We studied 21,595 and 5105 patients’ ICU stays from the e-Intensive Care Unit Collaborative Research (eICU) and Medical Information Mart for Intensive Care IV (MIMIC-IV) databases, respectively. Using the learned AI policy, we estimated the hospital mortality rate (eICU 12.1%, SD 3.1%; MIMIC-IV 29.1%, SD 0.9%), the proportion of optimal oxygen saturation (eICU 58.7%, SD 4.7%; MIMIC-IV 49%, SD 1%), and the proportion of optimal mean arterial blood pressure (eICU 31.1%, SD 4.5%; MIMIC-IV 41.2%, SD 1%). Based on multiple quantitative and qualitative evaluation metrics, our proposed AI solution outperformed observed clinical practice.

Conclusions
Our study found that customizing ventilation settings for individual patients led to lower estimated hospital mortality rates compared to actual rates. This highlights the potential effectiveness of using reinforcement learning methodology to develop AI models that analyze complex clinical data for optimizing treatment parameters. Additionally, our findings suggest the integration of this model into a clinical decision support system for refining ventilation settings, supporting the need for prospective validation trials.
Allocative Efficiency Of Rice Farming Under Landscape Integrated Pest Management Program In Klaten District
Authors: Natriasukma Muhammad Pradipta , Hardyastuti Suhatmini , Irham  
Published: September 2024

The research aims to (1) identify the factors that influence rice production of landscape IPM and non-landscape IPM farming, (2) analyze the allocative efficiency of rice production factors use under landscape IPM and non-landscape IPM farming, (3) analyze the factors that influence rice farming income of landscape IPM and non-landscape IPM farming, and (4) analyze of IPM field school on the use of chemical pesticides. This research was conducted in December 2018 - July 2019. The basic method of this research was survey. The research location was in Klaten District as one of the landscape IPM program sites. The sample consisted of 30 landscape IPM rice farmers and 30 non-landscape IPM rice farmers who determined by simple random sampling. Data were analyzed by using multiple linear regression equation and Ordinary Least Square (OLS) method with Cobb-Douglas production function. The results of the study are as follow: (1) farmers in Klaten District who applied the principle of landscape IPM had higher rice productivity and farm income, (2) the use of land size and seed on landscape IPM farmers and land use in landscape IPM has not been efficient so that it can still increase land size and seeds to increase rice production (3) increasing in seed prices and wages of hired labor can reduce rice farming income. Meanwhile, the expansion of land size can increase rice farming income, (4) IPM field school has the effect of using fewer chemical pesticides by farmers.
A Comparative Study of Different Staining Techniques for Cellulase Activity on CMC (Carboxy Methyl Cellulose) Agar
Authors: Bambharolia R. P. , Vyas Trupti K. , Vavdiya P. A. , Damasia D. M. , Garaniya N. H. , Deshmukh A. J. 
Published: September 2024

The present experiment was conducted at Department of Plant Pathology, College of Agriculture, Navsari Agricultural University, WaghaiduringMarch-October, 2021. cellulolytic bacterial isolates CD11, CD17, CD19, CD22 and CD35 were screened to determine the staining efficiency of various stains for cellulase activity on CMC(Carboxy Methyl Cellulose) agar and it was observed that all the isolates conferred clear zone around the colonies through different staining dyes and bacterial isolate CD35 showed the highest cellulolytic index in all the dyes. The cellulolytic index of CD35 was highest with gram’s iodine (3.34) next in order of coomassie brilliant blue (2.96), safranin (2.55) and congo red (2.15).Significantly, higher cellulase activity was recorded in CD35 (0.169 Uml-1) at 24 hrs after inoculation It was followed by CD17 (0.124 Uml-1), CD19 (0.101 Uml-1) and CD11 (0.081 Uml-1), while it was lowest in CD22 (0.052 Uml-1). Maximum cellulase activity was recorded at 72 hrs after inoculation by all the selected isolates except CD22 isolate, which was maximum 96 hrs after inoculation. CD35 gave significantly maximum cellulase activity (0.822 Uml-1) at 72 hrs after inoculation. Next in order to cellulase activity was CD17 (0.477 Uml-1) which was at par with CD19 (0.471 Uml-1) followed by CD11 (0.292 Uml-1) while, it was lowest in CD22 (0.199 Uml-1).Cellulolytic bacteria CD35 was identified as Bacillus subtilis by morphological, biochemical and molecular methods and submitted to NCBI GenBank database with accession numbers MW715021.
Tahapan Pengambilan Keputusan dan Faktor-faktor yang Mempengaruhi Adopsi Inovasi Teknologi Pengolahan Pala di Kecamatan Bayang Kabupaten Pesisir Selatan
Authors: Fahmi Sepno , Tanjung Hery Bachrizal , Irfan Zul 
Published: September 2024

Penelitian ini bertujuan untuk menganalisis tahapan pengambilan keputusan adopsi inovasi teknologi pengolahan pala dan faktor-faktor yang mempengaruhi pengambilan keputusan adopsi inovasi teknologi pengolahan pala oleh anggota kelompok tani Bayang Bungo Indah di Kecamatan Bayang, Kabupaten Pesisir Selatan. Penelitian ini bersifat explanatory research (penelitian eksplanatoris). Metode yang digunakan dalam penelitian ini adalah metode sensus. Selanjutnya dalam analisis data digunakan SEM menggunakan software SmartPLS. Hasil penelitian menunjukkan bahwa tahapan pengambilan keputusan adopsi inovasi teknologi pengolahan pala yang dilalui oleh anggota kelompok tani Bayang Bungo Indah, yaitu: tahap pengetahuan, persuasi, keputusan, implementasi, dan konfirmasi. Faktor-faktor yang mempengaruhi pengambilan keputusan adopsi inovasi teknologi pengolahan pala oleh petani di Kecamatan Bayang, Kabupaten Pesisir Selatan adalah karakteristik petani, sifat inovasi, kualitas penyuluhan, dan intensitas komunikasi anggota kelompok tani. Faktor yang paling berpengaruh terhadap pengambilan keputusan adopsi inovasi teknologi pengolahan pala pada variabel karakteristik petani adalah tingkat pendapatan, pada variabel sifat inovasi adalah kemudahan diamati, pada variabel kualitas penyuluhan adalah kemampuan penyuluh, dan pada variabel intensitas komunikasi anggota kelompok tani adalah komunikasi kelompok.