bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and bioactivity studies of the potato tuber moth, Phthorimaea operculella Zeller (Lepidoptera: Gelechiidae) sex pheromone analogs
Authors: Yan Junjie , Zhang Mengdi , Li Jing , Rondon Silvia I. , Gao Yulin 
Published: October 2024

AbstractBACKGROUNDPotato (Solanum tuberosum L.) is a staple food crop globally, but its production is consistently threatened by diseases and arthropod pests like the potato tuber moth, Phthorimaea operculella Zeller (Lepidoptera: Gelechiidae). Phthorimaea operculella is often controlled by chemical applications. Sex pheromones have been used to detect, monitor, or control agricultural pests. Phthorimaea operculella sex pheromones mainly contain two chemical structures, 4E,7Z‐trisadene‐1‐ol acetate and 4E,7Z,10Z‐trisadene‐1‐ol acetate. However, the pheromone analogs are expected to act as mimics, synergists, antagonists, and inhibitors for pheromones and can be synthesized at a large scale.RESULTIn this study, a total of 11 sex pheromone analogs of P. operculella were designed and synthesized. Results showed that the antennae exhibited a concentration‐dependent response to sex pheromones and their analogs. Different analogs and dosages had significant effects on the electrophysiological response of the antennae. In the field trials, when used alone, A6, B3 and B5 exhibited significant trapping effects in tobacco and potato fields. When used alternately with sex pheromone components, the analog B3 had significantly higher trapping effects in both tobacco and potato fields compared to the control, while combinations containing fluorinated analogs showed lower trapping effects.CONCLUSIONIn summary, the use of sex pheromone analogs holds great promise for integration into pest management programs. Further investigation to fine‐tune dosage and duration for optimal use is still needed. © 2024 Society of Chemical Industry.
Ventricular interdependent phenotype of mixed Cpc‐pulmonary hypertension and HFpEF with normal left atrium: Impact on CPET metrics and clinical outcomes
Authors: Zampierollo‐Jaramillo Giovanna , Abed Anas , El Shaer Ahmed , Garcia‐Arango Mariana , Chen Yimin , Tehrani Babak , Tu Wanxin , Arif Abdul Wahab , Heffernan Shannon , Esmaeeli Amir , Sahai Aditya , Runo James , Baber Aurangzeb , Masri Sofia C. , Raza Farhan 
Published: October 2024

AbstractAmong 45 CpcPH/heart failure with preserved ejection fraction participants, 11 with normal left atrium (compared to 34 with abnormal left atrium, p < 0.05 for all) had low left ventricle (LV) transmural pressure (2.9 ± 2.4 vs. 6.2 ± 2.9 mmHg), and increased right ventricle (RV):LV ratio (2.41 ± 1.09 vs. 1.46 ± 0.66) and interventricular septal angle (149 ± 8 vs. 136 ± 10), indicating exaggerated ventricular interdependence from a dilated RV.
Enhancing Maneuverability in a Variable Wheelbase Wheeled Mobile Robot Through Dynamic Steering Curvature Control
Authors: Qi Huanan , Li Xinyu , Ding Liang , Cheng Qiannan , Gao Haibo , Terze Zdravko , Deng Zongquan 
Published: October 2024

ABSTRACTVariable wheelbase wheeled mobile robot (VW‐WMR) is capable of maneuvering flexibly and traversing on rough and soil terrains within confined spaces. While the steering radius of the robot model can be robustly changed by the variable wheelbase length, a challenge is posed in accurately tracking a predefined trajectory through the alteration of wheelbase length. A dynamic steering curvature (DSC) control method is proposed in this work to overcome this challenge, which is achieved by two different approaches utilizing the variable wheelbase length and manipulating drifting motions. First, to enable flexible trajectory adjustments, a 3D Ackermann kinematics model, incorporating the lifting motion of the robot box, is developed to control steering curvature by the changes in wheelbase length. Second, to achieve flexible movement for the inner and outer curves of the originally planned curvilinear trajectory, Ackermann drift models are presented by the establishment of two sequence instantaneous centers. Furthermore, the control performance of DSC is validated through simulation experiments on the ROSTDyn Vortex platform, using a six‐wheeled VW‐WMR named HIT‐MRII robot. The effectiveness of DSC for strategically altering the robot's motion trajectory is demonstrated by the results, which show the relation between the changed trajectory position and the variation in wheelbase length, and the variation in the radii of the instantaneous centers (ICs) in the Ackermann drift model, respectively. In addition, the high maneuverability of the robot using the Ackermann model is proven by physical experiments during steering motions on soil terrain. A comprehensive advantage is demonstrated by the results via Ackermann models, which include shorter runtimes, moderate travel distances, and moderate variations in force on the wheels, compared to different velocity, crabbing motion, and equivalent bicycle models.
When colleagues compete outside the firm
Authors: Grohsjean Thorsten , Piezunka Henning , Mickeler Maren 
Published: October 2024

AbstractResearch SummaryCollaboration among employees is the bedrock of an organization, but we suggest that it can be undermined by their extra‐organizational affiliations. We point to the hidden but common constellation of two coworkers who are also affiliated with organizations that compete with one another. We hypothesize that such colleagues collaborate less with one another when performing on behalf of their shared employer. Using data from professional soccer, we provide empirical evidence. We outline implications for research on extra‐organizational affiliations, intraorganizational collaboration, competition and rivalry, and social networks.Managerial SummaryImagine two soccer players who play for the same soccer club – but compete against one another when they perform on behalf of their national team (i.e., the two players have different nationalities). We show that the two soccer players collaborate less (i.e., play fewer passes to each other) at their club after encountering each other as opponents when performing on behalf of their national teams. This finding in the context of sports has implications for firms. Managers of the same firm may serve on boards of directors of companies that compete with each other, and employees may support political parties that compete – eventually hindering internal collaboration.
Tumor‐Selective Nano‐Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll‐Like Receptors
Authors: Liu Yang , Li Hui , Hao Yan‐Yun , Huang Ling‐Ling , Li Xia , Zou Jing , Zhang Shi‐Ying , Yang Xiao‐Yue , Chen Hong‐Fei , Guo Yi‐Xuan , Guan Yun‐Yan , Zhang Zhi‐Yue 
Published: October 2024

AbstractThe development of tumors relies on lactate metabolic reprogramming to facilitate their unchecked growth and evade immune surveillance. This poses a significant challenge to the efficacy of antitumor immunity. To address this, a tumor‐selective nano‐dispatcher, PIMDQ/Syro‐RNP, to enforce the immunotherapeutic effect through regulation of lactate metabolism and activation of toll‐like receptors is developed. By using the tumor‐targeting properties of c‐RGD, the system can effectively deliver monocarboxylate transporters 4 (MCT4) inhibitor (Syro) to inhibit lactate efflux in tumor cells, leading to decreased lactate levels in the tumor microenvironment (TME) and increased accumulation within tumor cells. The reduction of lactate in TME will reduce the nutritional support for regulatory T cells (Tregs) and promote the effector function of T cells. The accumulation of lactate in tumor cells will lead to tumor death due to cellular acidosis. In addition, it will also reduce the uptake of glucose by tumor cells, reduce nutrient plunder, and further weaken the inhibition of T cell function. Furthermore, the pH‐responsive release of Toll‐like receptors (TLR) 7/8 agonist IMDQ within the TME activates dendritic cells (DCs) and promotes the infiltration of T cells. These findings offer a promising approach for enhancing tumor immune response through targeted metabolic interventions.
Advances in neuroscience research and big data's analysis on anxiety disorder
Authors: Yu Qianmei , Ruan Meihua , Chen Yongjun , Wang Chun 
Published: October 2024

AbstractAnxiety disorder is a complex disease with the influence of environmental and genetic factors and multimolecular participation, and it is also one of the most common mental disorders. The causes of disorders are not clear but may include a variety of social, psychological, and biological factors. Therefore, neither genetics, neurobiology, nor neuroimaging can independently explain the pathological mechanism. By searching the Web of Science databases, Derwent Innovation Patent database, ClinicalTrials.gov database, and Cortellis database, we analyze the current situation of papers, patents, clinical trials, and drugs of anxiety disorder. Second, the existing literature was reviewed to summarize the neurophysiological mechanism, brain imaging, gene, anti‐anxiety drugs, and other aspects of anxiety disorders. This article reviews the research status of anxiety disorders. The heterogeneity of the disease, lack of treatment effectiveness, and gaps in translational medicine still present barriers to further advancement. Thus, in‐depth explorations of the underlying biological mechanisms of anxiety disorders, the detection and intervention of biological targets, and further developments based on existing intervention strategies will drive future research on anxiety disorders.This article is categorized under:
Neuroscience > Clinical
Application of coupled MIKE SHE/MIKE HYDRO on streamflow dynamics under climate change in Lake Tana sub basin, Abay Basin, Ethiopia
Authors: Fetene Damte Tegegne , Lohani Tarun Kumar , Mohammed Abdella Kemal 
Published: October 2024

AbstractWater availability and quality are fluctuating due to climate change, which has disastrous effects on life. Modeling climate change impact on streamflow in the Lake Tana sub‐basin (LTSB) in selected watersheds was the main goal of the research. This research is unique in that it applies the coupled MIKE SHE/MIKE HYDRO model technique, which has not been applied before to investigate changes in streamflow due to climate change in LTSB. Streamflow in the LTSB was forecasted using the MIKE SHE/MIKE HYDRO model from seven ensembles of GCMs under two emission scenarios (SSP2–4.5 and SSP5–8.5) between 2041 and 2,100. According to the calibration and validation results in the period of 1985–2007, MIKE SHE performs well while simulating streamflow in LTSB. During calibration and validation, the Nash‐Sutcliffe efficiency (NSE) values in all watersheds were greater than 0.8, except for the Ribb watershed calibration, where it was 0.75. The mean monthly changes in temperatures indicate an incremental tendency in the next decades. According to the simulation result, the monthly mean rainfall for SSP2–4.5 and SSP5–8.5 will increase from 0.05 to 61.9% and 2.02 to 46.26% in the 2050s and 8.7 to 44.38% to 6.44 to 66.24% in the 2080s, respectively. Gilgle Abay, Gumara, and Ribb watersheds will lose 56.2, 56.65, 57.01% of their mean monthly streamflow in the 2050s, according to SSP2–4.5. For the Gilgle Abay, Gumara, and Ribb watersheds, streamflow will increase by 6.7% to 21.94%, 6.08% to 23.26%, and 6.51% to 22.88%, accordingly, in the 2050s under SSP5–8.5. Increased rainfall in the watershed could result in floods in the already‐flooded Gumara and Ribb flood plains. The government and community should implement coping mechanisms to lessen the impact of climate change like early warring and planting more trees. Overall, the study showed that it is expected that conditions related to streamflow may change in the future due to climate alteration. By offering a better understanding of current and future climates, the integrated modeling system developed can assist environmentalists, hydrologists, and policymakers in water management and policy intervention.
Spatial variation in physicochemical water quality parameters associated with Rice farming in the Dakalt Branch Canal, Kafrelsheikh governorate, Egypt
Authors: Ochieng Onyango Cersey , Morara Ogendi George , Samir Donia Noha 
Published: October 2024

AbstractThe inappropriate use of chemical fertilizers and pesticides in rice farming has been identified as a significant source of pollution in the aquatic environments. The declining water quality has been a cause of concern for the riparian communities owing to ill health associated with the usage of contaminated water from lotic systems draining such rice‐growing areas and its potential to cause lethal and sublethal effects on aquatic organisms. The spatial variation of selected water quality parameters was assessed using multivariate techniques. Data from three sampling stations, collected in triplicates, were analyzed to understand the effects of rice farming practices on the Dakalt Branch Canal's water quality. Eleven physicochemical parameters were measured in situ with a portable multimeter, while nutrients and other chemical parameters were determined following the standard procedures outlined in the American Public Health Association using the UV/Visible spectrophotometer. One‐way ANOVA was used to establish whether or not there were significant differences among means of various parameters. The findings revealed considerable spatial variability in the means for nearly all water quality parameters (p < 0.05). The Water Quality Index revealed that all the sampling stations were polluted with indices of more than 100. We conclude that poor rice management practices are responsible for the observed pollution of the River Nile and potentially lethal and sublethal effects on aquatic organisms and human health. We therefore recommend regular monitoring of the water quality of the Dakalt Branch Canal and that the relevant stakeholders, including farmers, embrace Best Management Practices, especially when applying pesticides and fertilizers.
Ranavirus Replication: New Studies Provide Answers to Old Questions
Authors: Jancovich James K. , Zhang Qi-Ya , Chinchar V. Gregory 
Published: October 2024

AbstractThis updated review is presented in two parts. The first, based primarily on work conducted since the discovery of the first ranavirus in the mid-1960s and extending through 2014, summarizes ranavirus taxonomy, the viral life cycle, the impact of infection on the host cell, and the host immune response to viral infection. The second part, drawing on research conducted mainly since the first edition of this monograph in 2015, describes genetic and molecular approaches for determining ranavirus gene function and outlines the role of viral gene products in orchestrating events leading to the production of infectious virions, cytopathology, and the inhibition of host anti-viral immunity. Furthermore, because our understanding of certain events in ranavirus replication remains to be elucidated, areas requiring further research are highlighted.
Ranavirus Ecology: From Individual Infections to Population Epidemiology to Community Impacts
Authors: Brunner Jesse L. , Storfer Andrew , Le Sage Emily H. , Garner Trenton W. J. , Gray Matthew J. , Hoverman Jason T. 
Published: October 2024

AbstractWhile ranaviruses were initially a focus of scientific study primarily among virologists, the continued and growing interest in them stems largely from their impacts on host populations and communities. Here, we present an overview of what is known of ranavirus ecology in individual hosts (e.g., the many factors that influence the likelihood and outcome of ranavirus infections), in host populations and communities (e.g., transmission, persistence, and the causes of such varied outcomes of epidemics), and across landscapes, with a focus on how processes or outcomes at one level might scale up to the next level. Throughout the chapter, we also highlight important unanswered questions and research challenges and opportunities.
Biotransformation of diclofenac by Stenotrophomonas humi strain DIC_5 and toxicological examination of the resulting metabolites
Authors: Pápai Márton , Benedek Tibor , Sörös Csilla , Háhn Judit , Csenki Zsolt , Bock Illés , Táncsics András , Kriszt Balázs 
Published: October 2024

Abstract
The widely used non-steroidal anti-inflammatory drug, diclofenac, detected in increasing concentrations in freshwater ecosystems, is among the most pressing environmental problems today. In this study, the bacterial isolate Stenotrophomonas humi strain DIC_5 was capable of degrading diclofenac. It eliminated 75.1% of diclofenac at an initial concentration of 1.5 mg/L after 8 days in the presence of glucose (3.0 g/L). During the process, nitro-diclofenac was identified as a resulting metabolite, whose concentration increased significantly in the bacterial medium from the 7th day of the experiment, while the concentration of diclofenac decreased correspondingly. The ecotoxicological tests on Aliivibrio fischeri and zebrafish embryos showed that the bacterial metabolites without diclofenac have a higher toxicity (up to 35.5% bacterial bioluminescence inhibition and 36.7% embryo mortality) than the diclofenac degradation residues (28% and 26.7%, respectively). Based on these results, neither diclofenac nor its degradation products exhibit toxic effects on the test organisms. Conversely, the toxic effect caused by the bacteria was reduced in the presence of diclofenac. Our work highlights the importance of using biotic controls in biotransformation trials, especially when the foreign material is applied in intermediate or environmentally relevant concentration ranges.

Key points
• Biotransformation of diclofenac by bacteria isolated from a bacterial biofilm.
• Biotransformation of diclofenac led to the formation of nitro-diclofenac.
• Microorganisms are alternatives for reducing the concentration of diclofenac in water.
Audiovestibular symptoms in systemic sclerosis: a systematic review and meta-analysis
Authors: Salvador Craig D. , Keith Brian A. , Ward Celine , Nguyen Shaun A. , Gordis Tamar , Chidarala Shreya , Brennan Emily , Rizk Habib 
Published: October 2024

Abstract
Purpose
Answer the following PICO question: Are patients diagnosed with systemic sclerosis (SSc) (Population) who are evaluated clinically and audiometrically (Intervention), have a higher prevalence of audiovestibular pathology when compared with non-SSc patients (Comparison), and how do they present symptomatically and on testing audiovestibular symptomatology and testing modalities (Outcome)?

Methods
A systematic review and meta-analysis was performed. PubMed, Scopus, CINAHL, and Cochrane Library databases were searched from inception to November 27, 2023. Studies of patients diagnosed with SSc and audiologic and vestibular symptoms were selected for review. Studies of non-SSc pathologies, studies without audiovestibular outcomes, and case reports (fewer than four patients) were excluded. A meta-analysis of proportions and comparison of weighted proportions was performed in MedCalc 20.217.

Results
Thirteen studies with 414 SSc patients and 390 control patients were included. The mean ± SD symptom duration was 108.5 ± 71.8 (range: 6-600) months for SSc patients. Comparison of proportions showed patients with SSc were significantly more burdened with symptoms of tinnitus (Δ34.1% [95% CI, 27.6–40.5]; p < 0.0001), vertigo (Δ32.4% [95% CI, 24.8–40.3]; p < 0.0001), and subjective hearing loss (Δ26.0% [95% CI, 20.8–31.3]; p < 0.0001) compared to control patients. Findings regarding vestibular testing were not meta-analyzable because of incomplete data and lack of standard reporting.

Conclusion
SSc patients showed statistically significant, yet not clinically significant, worse hearing than controls. These differences, along with increased reports of subjective audiological and vestibular symptoms in patients with SSc, emphasize interdisciplinary collaboration and assessment of SSc for audiovestibular pathologies in the appropriate clinical context.
Uterine mesenchymal tumours harboring the KAT6B/A::KANSL1 gene fusion represent a distinct type of uterine sarcoma based on DNA methylation profiles
Authors: Kommoss Felix K. F. , Charbel Alphonse , Kolin David L. , Howitt Brooke E. , Köbel Martin , Lee Jen-Chieh , McCluggage W Glenn , Agaimy Abbas , Dickson Brendan C. , von Deimling Andreas , Lee Cheng-Han 
Published: October 2024

AbstractUterine mesenchymal tumours harboring KAT6B/A::KANSL1 gene fusions typically exhibit histological and immunophenotypic overlap with endometrial stromal and smooth muscle tumours. To date it remains uncertain whether such neoplasms should be regarded as variants of smooth muscle or endometrial stromal neoplasm, or if they constitute a distinct tumour type. In this study we investigated DNA methylation patterns and copy number variations (CNVs) in a series of uterine tumours harboring KAT6B/A::KANSL1 gene fusions in comparison to other mesenchymal neoplasms of the gynecological tract. Unsupervised hierarchical clustering and t-SNE analysis of DNA methylation data (Illumina EPIC array) identified a distinct cluster for 8/13 KAT6B/A::KANSL1 tumours (herein referred to as core cluster). The other 5 tumours (herein referred to as outliers) did not assign to the core cluster but clustered near various other tumour types. CNV analysis did not identify significant alterations in the core cluster. In contrast, various alterations, including deletions at the CDKN2A/B and NF1 loci were identified in the outlier group. Analysis of the DNA methylation clusters in relation to histological features revealed that while tumours in the core KAT6B/A::KANSL1 cluster were histologically bland, outlier tumours frequently exhibited “high-grade” histologic features in the form of significant nuclear atypia, increased mitotic activity and necrosis. Three of the five patients with outlier tumours died from their disease while clinical follow-up in the remaining two patients was limited (less than 12 months). In comparison, none of the 7 out of 8 patients with tumors in the core KAT6B/A::KANSL1 sarcoma cluster, where follow-up was available, died from disease. Furthermore, only 1 out of 7 patients recurred (mean follow-up of 30 months). In conclusion, KAT6B/A::KANSL1 uterine sarcoma is a molecularly unique type of uterine tumour that should be recognized as a distinct entity. These tumors typically exhibit low-grade histologic features but are occasionally morphologically high-grade; the latter have a DNA methylation profile different from the typical low-grade neoplasms and may be associated with aggressive behaviour.
Diagnostic utility of ESR1 mutation detection in liquid biopsy of metastatic breast cancer patients
Authors: Sandbothe Maria , Hasemeier Britta , Schipper Elisa , Schaumann Nora , Kreipe Hans , Lehmann Ulrich , Bartels Stephan 
Published: October 2024

AbstractMolecular analysis of circulating cell-free DNA (cfDNA) extracted from peripheral blood plasma samples of metastatic breast cancer (BC) patients is of rising interest to find optimal therapeutic strategies. Detection of emerging resistance mutations against endocrine therapy is possible with this approach. Here we present the applicability of a laboratory-developed NGS assay in molecular pathology routine diagnostic, covering four genes with therapeutic (ESR1, PIK3CA, ERBB2) and prognostic (TP53) consequences in metastatic BC. We analyzed 162 liquid biopsy samples and 25 corresponding metastases from metastatic BC patients. In the liquid biopsies, we detected ESR1 mutations in 42 cases (25.9%) and ERBB2 mutations in six cases (3.7%), arguing for a change in therapy to fulvestrant, elacestrant, or neratinib. Furthermore, 17 cases had detectable TP53 mutations, associated with resistance against endocrine therapy. We conclude that liquid biopsy testing is a noninvasive, sensitive, and helpful method to optimize therapeutic decisions in metastatic BC.