bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exoneraties voor indirecte schade
Authors: Dousi J.W.A. 
Published: March 2017

Exoneraties voor indirecte schade
Een veelgebruikte aansprakelijkheidsbeperking (exoneratie) is een uitsluiting voor zogenoemde ‘indirecte schade’. Deze term is afkomstig uit het Anglo-Amerikaanse recht. De auteur bespreekt deze Anglo-Amerikaanse achtergrond en betoogt dat deze achtergrond, afhankelijk van de omstandigheden van het geval, een gezichtspunt kan zijn bij de uitleg van dit begrip naar Nederlands recht en bovendien een bron van inspiratie voor contractspartijen wanneer zij bij het opstellen van het contract een definitie opnemen van de term ‘indirecte schade’. De auteur concludeert dat de Anglo-Amerikaanse betekenis goed is in te passen in het Nederlandse recht, omdat zij aansluit bij (en kan fungeren als een verdere verfijning van) het element voorzienbaarheid in de toerekeningstoets van artikel 6:98 BW.
O NASCIMENTO BIOLÓGICO DA CRIANÇA
Authors: Sigueira Arnaldo Augusto Franco de 
Published: March 2017

O presente trabalho trata da fisiologia do nascimento e da adaptação da criança à vida extra-uterina, assim como de suas repercussões no crescimento e no desenvolvimento posterior. São discutidos os agravos de maior risco de repercussão para o crescimento e principalmente para o desenvolvimento neuromotor e psicológiCO7 quais sejam: duração da gravidez; tamanho do feto e tipo de parto; assistência ao recém-nascido; hipóxia perinatal; icterícia do recém-nascido.Concluindo, enfatiza a improtancia de um “bom começo” a partir de condições facilitadoras e adequadas ao nascimento para que o processo vital da criança possa atingir toda sua potencialidade.
Annulative π‐Extension (APEX): Rapid Access to Fused Arenes, Heteroarenes, and Nanographenes
Authors: Ito Hideto , Ozaki Kyohei , Itami Kenichiro 
Published: March 2017

AbstractThe annulative π‐extension (APEX) reaction has the potential to have a tremendous impact on the fields of materials science and bioimaging, as well as on the pharmaceutical/agrochemical industries, since it allows access to fused aromatic systems from relatively simple aromatic compounds in a single step. Typically, an APEX reaction facilitates a one‐pot π‐extension without the need to prefunctionalize the aromatic compounds. This advantageous feature is extremely useful for tuning and modifying molecular properties in the last step of a synthesis. In this Review, the progress and applications of APEX reactions of unfunctionalized arenes and heteroarenes are described.
Multipath routing algorithm for application‐specific wormhole NoCs
Authors: ZhuanSun Zongliang , Li Keqiu , Chen Guolong 
Published: March 2017

SummaryAdaptive routing designing for network‐on‐chip architecture is complicated to guarantee deadlock‐free. In this paper, we present methodology to design efficient multi‐path routing algorithms for specific application wormhole network‐on‐chip system to guarantee deadlock‐free. The methodology presents an analytical model for overall average delay of wormhole network‐on‐chip by queueing theory and uses a linear programming–based methodology to minimize overall average delay. The methodology guarantees deadlock freedom by efficient branch‐and‐bound algorithm. Compared to other adaptive deadlock‐free algorithms, results obtained through simulation show that the algorithms can potentially achieve better throughput and latency.
A quantum‐inspired binary gravitational search algorithm–based job‐scheduling model for mobile computational grid
Authors: Singh Krishan Veer , Raza Zahid 
Published: March 2017

SummaryOwing to the advancements in low‐power consumption processors and high‐power storage in a small‐sized battery, the cost of handheld mobile devices, eg, mobiles, tabs, or personal digital assistants, have reduced to a great extent. This has enabled people to have at least 1 smartphone in general with this number increasing exponentially. However, the increasing use of these mobile devices results in an equal increase in the underused processing capacity of these devices too. This encourages the research aiming to use this processing power by forming a mobile computational grid. Because of the inherent limitations of bandwidth, battery, and computational power, job scheduling on these devices demands an efficient scheduling approach to harness the true potential of the grid. The problem becomes even more challenging considering the dynamic nature of these mobile devices. Job scheduling being nondeterministic polynomial time–complete allows the use of evolutionary approaches by exploring and exploiting the search space efficiently. The exploration gets boosted even more with the use of quantum‐computing concepts. This work proposes a quantum‐inspired Newtonian approach of attraction based on gravitational search algorithm for scheduling the jobs on mobile computational grid. Simulation study has been performed to evaluate the performance of the model over various dimensions. A comparative study has been performed with quantum‐genetic algorithm. Simulation result establishes the effectiveness of model under various test conditions.
User biometric information‐based secure method for smart devices
Authors: Su Xin , Wang Bingying , Zhang Xuewu , Wang Yupeng , Choi Dongmin 
Published: March 2017

SummarySecure mechanisms have been adapted to satisfy the needs of mobile subscribers; however, the mobile environment is quite different from a desktop PC or laptop‐based environment. The existing attack patterns in mobile environments are also quite different, and the countermeasures applied should be enhanced. In regards to usability, the mobile environment is based on mobility, and thus, mobile devices are designed and developed to enhance the owner's efficiency. To avoid forgetting passwords, people are willing to adopt simple alphanumeric‐character combinations, which are easy to remember and convenient to enter. As a result, the passwords have a high probability of being cracked or exposed. In this paper, we study the potential security problems caused by simple and weak passwords, discuss drawbacks of some conventional works, and propose 3 creative schemes to increase the complexity and strength of passwords by applying the envisioned features. Note that our proposals are based on the assumption that the textual passwords are not difficult for users to remember or enter and do not cause inconvenience to users. In other words, the proposed methods can increase the complexity of simple passwords without the awareness of users.
Getting to the root of fireworms' stinging chaetae—chaetal arrangement and ultrastructure of Eurythoe complanata (Pallas, 1766) (Amphinomida)
Authors: Tilic Ekin , Pauli Benedikt , Bartolomaeus Thomas 
Published: March 2017

AbstractAmphinomid species are since long known to cause urtication upon contact with the human skin. Since it has been reported that amphinomid chaetae are hollow, it has repeatedly been suggested that poison is injected upon epidermal contact. To test predictions for the structural correlate of such a stinging device we studied the structure and formation of chaetae in the fireworm Eurythoe complanata (Amphinomida). Neither the structure of the chaetae nor their formation and their position within the parapodium provide evidence for their function as hollow needles to inject poison. The chaetae even turned out to be not hollow, but containing calcareous depositions. The latter most likely cause artificial ruptures of delicate chitin lamellae in the inner of the chaeta when treated with acidic fixatives. Inorganic calcium compounds harden the chaetae and make them brittle so that they break easily. Additional information on the structure of the chaetal sac, the site of formation and the acicula do not contradict the position of the Amphinomida within Annelida as revealed by phylogenomic studies.
Fruit quality of seedless watermelon grafted onto squash rootstocks under different production systems
Authors: Liu Qianru , Zhao Xin , Brecht Jeffrey K , Sims Charles A , Sanchez Tatiana , Dufault Nicholas S 
Published: March 2017

AbstractBACKGROUNDThe market demand for seedless watermelon has been continuously increasing because of consumer preference. Grafting is a useful tool to manage soilborne diseases in watermelon production, but the use of squash rootstocks may negatively affect watermelon fruit quality. Currently, most research has focused on seeded cultivars, while grafting effects on seedless watermelons remain largely unknown. This multi‐season study was conducted to assess the effects of squash rootstocks, including both Cucurbita maxima × C. moschata and C. moschata cultivars, with intact or excised and regenerated roots, on fruit quality of seedless watermelon ‘Melody’ using both instrumental and sensory measurements under different production scenarios. The grafted watermelon plants were also challenged by field inoculation with Fusarium oxysporum f.sp. niveum.RESULTSA combination of instrumental measurements and consumer sensory analyses suggested that fruit quality of the seedless watermelon ‘Melody’ was not impacted by the use of the squash rootstocks used in this study, which included soluble solids content, titratable acidity, pH and most fruit sensory properties. Watermelon flesh firmness was increased by grafting but the grafting effect on lycopene content was inconclusive. Root excision and regeneration did not influence the grafting effect, whereas the grafting effect on flesh firmness varied among the rootstocks under Fusarium inoculation.CONCLUSIONOverall, grafting with squash rootstocks did not reduce fruit quality attributes of ‘Melody’ but improved texture. Our results support incorporating grafting into integrated management programs for seedless watermelon production. © 2017 Society of Chemical Industry
Polymeric micro‐sequential concentric transcrystalline morphology self‐assembly, with intermittent self‐shear‐oriented amorphous layers
Authors: Stern Theodor 
Published: March 2017

The investigation and understanding of polymer crystallization processes, the resulting crystalline morphologies, and the mechanism of their formation is crucial in creating materials with desired properties for specific applications.The present research introduces and investigates a new polymeric crystalline morphology, observed for the first time in this research.This newly observed morphology, is a sequentially micro‐multi‐layered concentric morphology that self‐assembles throughout the bulk polymer matrix, with intermittent self‐shear‐oriented amorphous layers. The research analyses the structure and mechanism of its formation.Polarized light microscopy studies have shown a drastic and sudden morphology change that occurred during crystalline growth. Crystalline‐growth kinetics studies performed, showed a distinct pulsatile repeating growth pattern of approximately two growth pulses per second. Thermal analysis indicated the presence of two different populations of crystalline strength. Crystalline structure was analyzed by XRD pattern measurements. It was demonstrated here, that the sequential concentric transcrystalline morphology is nucleated on a shear‐oriented amorphous molecular layer in the adjacent melt formed during and as a consequence of crystalline growth, which occurs in a micro‐periodic sequences, with intermittent self‐sheared amorphous layers. The structure was confirmed by both scanning electron microscope and reflectance microscopy. Small angle X‐ray scattering measurements of the same materials reported in literature are consistent with the melt shear‐orientation theory described earlier.The discovery of this new crystalline morphology in this research, potentially opens a new door in the vast field of material properties and applications. Copyright © 2017 John Wiley & Sons, Ltd.
Repair of Torn Avascular Meniscal Cartilage Using Undifferentiated Autologous Mesenchymal Stem Cells: From In Vitro Optimization to a First-in-Human Study
Authors: Whitehouse Michael R. , Howells Nicholas R. , Parry Michael C. , Austin Eric , Kafienah Wael , Brady Kyla , Goodship Allen E. , Eldridge Jonathan D. , Blom Ashley W. , Hollander Anthony P. 
Published: March 2017

AbstractMeniscal cartilage tears are common and predispose to osteoarthritis (OA). Most occur in the avascular portion of the meniscus where current repair techniques usually fail. We described previously the use of undifferentiated autologous mesenchymal stem cells (MSCs) seeded onto a collagen scaffold (MSC/collagen-scaffold) to integrate meniscal tissues in vitro. Our objective was to translate this method into a cell therapy for patients with torn meniscus, with the long-term goal of delaying or preventing the onset of OA. After in vitro optimization, we tested an ovine-MSC/collagen-scaffold in a sheep meniscal cartilage tear model with promising results after 13 weeks, although repair was not sustained over 6 months. We then conducted a single center, prospective, open-label first-in-human safety study of patients with an avascular meniscal tear. Autologous MSCs were isolated from an iliac crest bone marrow biopsy, expanded and seeded into the collagen scaffold. The resulting human-MSC/collagen-scaffold implant was placed into the meniscal tear prior to repair with vertical mattress sutures and the patients were followed for 2 years. Five patients were treated and there was significant clinical improvement on repeated measures analysis. Three were asymptomatic at 24 months with no magnetic resonance imaging evidence of recurrent tear and clinical improvement in knee function scores. Two required subsequent meniscectomy due to retear or nonhealing of the meniscal tear at approximately 15 months after implantation. No other adverse events occurred. We conclude that undifferentiated MSCs could provide a safe way to augment avascular meniscal repair in some patients. Registration: EU Clinical Trials Register, 2010-024162-22.
Mesenchymal Stromal Cells Modulate Monocytes Trafficking in Coxsackievirus B3-Induced Myocarditis
Authors: Miteva Kapka , Pappritz Kathleen , El-Shafeey Muhammad , Dong Fengquan , Ringe Jochen , Tschöpe Carsten , Van Linthout Sophie 
Published: March 2017

Abstract
Mesenchymal stromal cell (MSC) application in Coxsackievirus B3 (CVB3)-induced myocarditis reduces myocardial inflammation and fibrosis, exerts prominent extra-cardiac immunomodulation, and improves heart function. Although the abovementioned findings demonstrate the benefit of MSC application, the mechanism of the MSC immunomodulatory effects leading to a final cardioprotective outcome in viral myocarditis remains poorly understood. Monocytes are known to be a trigger of myocardial tissue inflammation. The present study aims at investigating the direct effect of MSC on the mobilization and trafficking of monocytes to the heart in CVB3-induced myocarditis. One day post CVB3 infection, C57BL/6 mice were intravenously injected with 1 x 106 MSC and sacrificed 6 days later for molecular biology and flow cytometry analysis. MSC application reduced the severity of myocarditis, and heart and blood pro-inflammatory Ly6Chigh and Ly6Cmiddle monocytes, while those were retained in the spleen. Anti-inflammatory Ly6Clow monocytes increased in the blood, heart, and spleen of MSC-treated CVB3 mice. CVB3 infection induced splenic myelopoiesis, while MSC application slightly diminished the spleen myelopoietic activity in CVB3 mice. Left ventricular (LV) mRNA expression of the chemokines monocyte chemotactic protein-1 (MCP)−1, MCP-3, CCL5, the adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule-1, the pro-inflammatory cytokines interleukin-6, interleukin-12, tumor necrosis factor-α, the pro-fibrotic transforming growth factorβ1, and circulating MCP-1 and MCP-3 levels decreased in CVB3 MSC mice, while LV stromal cell-derived factor-1α RNA expression and systemic levels of fractalkine were increased in CVB3 MSC mice. MSC application in CVB3-induced myocarditis modulates monocytes trafficking to the heart and could be a promising strategy for the resolution of cardiac inflammation and prevention of the disease progression.
The Manuscripts that Never Were: In Search of the Tārīkh al-Fattāsh in Côte d’Ivoire and Ghana1
Authors: Nobili Mauro , Diagayeté Mohamed 
Published: March 2017

Abstract:This article presents a fieldwork report conducted by the authors to locate certain manuscripts – namely copies of the chronicle titled Tārīkh al-Fattāsh – listed in recent catalogues of Islamic manuscripts from Côte d’Ivoire and Ghana published by the al-Furqan Islamic Heritage Foundation and prepared by Bābā Yūnus Muḥammad. Unfortunately, after ten days of enquiry in the two countries, it became evident that the catalogues are inaccurate and that at least some of the manuscripts described do not exist.
Agile Working, the Entreployee and Generational Issues: Brave New World or Still Business as Usual at the Office?
Authors: Fishleigh Jackie 
Published: March 2017

AbstractThe concepts of agile working, the emergence of the entreployee and generational issues: are these concepts game changers or just gimmicks? Jackie Fishleigh examines new ways of office working in the commercial and information environments. Her thoughts are informed and inspired in part by her attendance at the London Law Expo, Europe's largest senior legal management conference and exhibition, which took place on 13th October 2015.
MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2
Authors: Ghosh Alip , Dasgupta Debanjali , Ghosh Amit , Roychoudhury Shrabasti , Kumar Dhiraj , Gorain Mahadeo , Butti Ramesh , Datta Simanti , Agarwal Shaleen , Gupta Subash , Krishna Dhali Gopal , Chowdhury Abhijit , Schmittgen Thomas D , Kundu Gopal C , Banerjee Soma 
Published: March 2017

AbstractIncreasing significance of tumor–stromal interaction in development and progression of cancer implies that signaling molecules in the tumor microenvironment (TME) might be the effective therapeutic targets for hepatocellular carcinoma (HCC). Here, the role of microRNA miR-199a-3p in the regulation of TME and development of HCC has been investigated by several in vitro and in vivo assays. Expression of miR-199a-3p was observed significantly low in HCC tissues and its overexpression remarkably inhibited in vivo tumor growth and metastasis to lung in NOD-SCID mice. In vitro restoration of miR-199a-3p expression either in endothelial cells (ECs) or in cancer cells (CACs) significantly diminished migration of ECs in co-culture assay. Again incubation of miR-199a-3p transfected ECs with either conditioned media (CM) of CACs or recombinant VEGF has reduced tube formation, in ECs and it was also dropped upon growth in CM of either anti-VEGF antibody-treated or miR-199a-3p-transfected CACs. In addition, bioinformatics and luciferase-reporter assays revealed that miR-199a-3p inhibited VEGF secretion from CACs and VEGFR1 and VEGFR2 expression on ECs and thus restricted cross talk between CACs and ECs. Again, restoration of miR-199a-3p in hepatic stellate cells (HSCs) reduced migration and invasion of CACs in co-culture assay, while it was enhanced by the overexpression of HGF suggesting miR-199a-3p has hindered HSC-CACs cross talk probably by inhibiting HGF and regulating matrix metalloproteinase MMP2, which were found as targets of miR-199a-3p subsequently by luciferase-reporter assay and gelatin zymography, respectively. Thus, these findings collectively highlight that miR-199a-3p restricts metastasis, invasion and angiogenesis in HCC and hence it may be considered as one of the powerful effective therapeutics for management of HCC patients.
A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor
Authors: Shen Weitao , Zhang Xuyao , Fu Xiang , Fan Jiajun , Luan Jingyun , Cao Zhonglian , Yang Ping , Xu Zhongyuan , Ju Dianwen 
Published: March 2017

AbstractRecombinant human arginase (rhArg), an enzyme capable of depleting arginine, has been shown to be an effective therapeutic approach for various cancers. Non-small-cell lung cancer (NSCLC), a histological subtype of pulmonary carcinoma, has a high rate of morbidity and mortality in the world. Thus, the need for novel and more effective treatment is urgent. In this study, it is the first time to report that rhArg could induce significant cytotoxicity and caspase-dependent apoptosis in NSCLC cells. Subsequently, our research revealed that rhArg dramatically stimulated autophagic response in NSCLC cells, which was proved by the formation and accumulation of autophagosomes and the conversion of microtubule-associated protein light chain 3 (LC3) from LC3-I to LC3-II. Furthermore, blocking autophagy by chloroquine or LY294002 remarkably enhanced rhArg-induced cytotoxicity and caspase-dependent apoptosis, suggesting that autophagy acted a cytoprotective role in rhArg-treated NSCLC cells. Further experiments showed that two signaling pathways including the Akt/mTOR and extracellular signal-regulated kinase pathway, and mitochondrial-derived reactive oxygen species (ROS) production were involved in rhArg-induced autophagy and apoptosis. Meanwhile, N-acetyl-L-cysteine, a common antioxidant, was employed to scavenge ROS, and we detected that it could significantly block rhArg-induced autophagy and cytotoxicity, indicating that ROS played a vital role in arginine degradation therapy. Besides, xenograft experiment showed that combination with autophagy inhibitor potentiated the anti-tumor efficacy of rhArg in vivo. Therefore, these results provided a novel prospect and viewpoint that autophagy acted a cytoprotective role in rhArg-treated NSCLC cells, and treatment with rhArg alone or combined with autophagy inhibitor could be a novel and promising therapeutic approach for NSCLC in vivo and in vitro.
Candidate Genes for Inherited Autism Susceptibility in the Lebanese Population
Authors: Kourtian Silva , Soueid Jihane , Makhoul Nadine J. , Guisso Dikran Richard , Chahrour Maria , Boustany Rose-Mary N. 
Published: March 2017

AbstractAutism spectrum disorder (ASD) is characterized by ritualistic-repetitive behaviors and impaired verbal/non-verbal communication. Many ASD susceptibility genes implicated in neuronal pathways/brain development have been identified. The Lebanese population is ideal for uncovering recessive genes because of shared ancestry and a high rate of consanguineous marriages. Aims here are to analyze for published ASD genes and uncover novel inherited ASD susceptibility genes specific to the Lebanese. We recruited 36 ASD families (ASD: 37, unaffected parents: 36, unaffected siblings: 33) and 100 unaffected Lebanese controls. Cytogenetics 2.7 M Microarrays/CytoScan™ HD arrays allowed mapping of homozygous regions of the genome. The CNTNAP2 gene was screened by Sanger sequencing. Homozygosity mapping uncovered DPP4, TRHR, and MLF1 as novel candidate susceptibility genes for ASD in the Lebanese. Sequencing of hot spot exons in CNTNAP2 led to discovery of a 5 bp insertion in 23/37 ASD patients. This mutation was present in unaffected family members and unaffected Lebanese controls. Although a slight increase in number was observed in ASD patients and family members compared to controls, there were no significant differences in allele frequencies between affecteds and controls (C/TTCTG: γ2 value = 0.014; p = 0.904). The CNTNAP2 polymorphism identified in this population, hence, is not linked to the ASD phenotype.