bluuebunny/crossref_metadata_2025_split huggingface dataset:
Researching European Union Agencies: What Have We Learnt (and Where Do We Go from Here)?
Authors: Egeberg Morten , Trondal Jarle 
Published: January 2017

AbstractThis review article, with a clear political science and public administration bias, takes stock of the existing literature on EU agencies and suggests a future research agenda. The article reviews studies on EU agencies' organization, tasks, proliferation and location in the political‐administrative space. Whether the advent of EU agencies tends to underpin a basically intergovernmental, transnational or supranational order has potentially huge consequences for the distribution of power across levels of government, for the degree of policy uniformity and pooling of administrative resources across countries, for the role of genuinely European perspectives in the policy process, and for accountability relations. Although the jury is still partly out on most topics, we see the contours of a more direct multilevel administration in which EU agencies not only constitute nodes within transnational agency networks, but in addition, in governance terms, relate more closely to the European Commission than to any other institution.
Identification of altered brain metabolites associated with TNAP activity in a mouse model of hypophosphatasia using untargeted NMR‐based metabolomics analysis
Authors: Cruz Thomas , Gleizes Marie , Balayssac Stéphane , Mornet Etienne , Marsal Grégory , Millán José Luis , Malet‐Martino Myriam , Nowak Lionel G , Gilard Véronique , Fonta Caroline 
Published: January 2017

AbstractTissue non‐specific alkaline phosphatase (TNAP) is a key player of bone mineralization and TNAP gene (ALPL) mutations in human are responsible for hypophosphatasia (HPP), a rare heritable disease affecting the mineralization of bones and teeth. Moreover, TNAP is also expressed by brain cells and the severe forms of HPP are associated with neurological disorders, including epilepsy and brain morphological anomalies. However, TNAP's role in the nervous system remains poorly understood. To investigate its neuronal functions, we aimed to identify without any a priori the metabolites regulated by TNAP in the nervous tissue. For this purpose we used 1H‐ and 31P NMR to analyze the brain metabolome of Alpl (Akp2) mice null for TNAP function, a well‐described model of infantile HPP. Among 39 metabolites identified in brain extracts of 1‐week‐old animals, eight displayed significantly different concentration in Akp2−/− compared to Akp2+/+ and Akp2+/− mice: cystathionine, adenosine, GABA, methionine, histidine, 3‐methylhistidine, N‐acetylaspartate (NAA), and N‐acetyl‐aspartyl‐glutamate, with cystathionine and adenosine levels displaying the strongest alteration. These metabolites identify several biochemical processes that directly or indirectly involve TNAP function, in particular through the regulation of ecto‐nucleotide levels and of pyridoxal phosphate‐dependent enzymes. Some of these metabolites are involved in neurotransmission (GABA, adenosine), in myelin synthesis (NAA, NAAG), and in the methionine cycle and transsulfuration pathway (cystathionine, methionine). Their disturbances may contribute to the neurodevelopmental and neurological phenotype of HPP.
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Chronic pain and impaired glial glutamate transporter function in lupus‐prone mice are ameliorated by blocking macrophage colony‐stimulating factor‐1 receptors
Authors: Yan Xisheng , Maixner Dylan W. , Li Fen , Weng Han‐Rong 
Published: January 2017

AbstractSystemic lupus erythematosus (SLE) is a multi‐organ disease of unknown etiology in which the normal immune responses are directed against the body's own healthy tissues. Patients with SLE often suffer from chronic pain. Currently, no animal studies have been reported about the mechanisms underlying pain in SLE. In this study, the development of chronic pain in MRL lupus‐prone (MRL/lpr) mice, a well‐established lupus mouse model, was characterized for the first time. We found that female MRL/lpr mice developed thermal hyperalgesia at the age of 13 weeks, and mechanical allodynia at the age of 16 weeks. MRL/lpr mice with chronic pain had activation of microglia and astrocytes, over‐expression of macrophage colony‐stimulating factor‐1 (CSF‐1) and interleukin‐1 beta (IL‐1β), as well as suppression of glial glutamate transport function in the spinal cord. Intrathecal injection of either the CSF‐1 blocker or IL‐1 inhibitor attenuated thermal hyperalgesia in MRL/lpr mice. We provide evidence that the suppressed activity of glial glutamate transporters in the spinal dorsal horn in MRL/lpr mice is caused by activation of the CSF‐1 and IL‐1β signaling pathways. Our findings suggest that targeting the CSF‐1 and IL‐1β signaling pathways or the glial glutamate transporter in the spinal cord is an effective approach for the management of chronic pain caused by SLE.
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Influence of sunflower seed oil or baby lotion on the skin barrier function of newborns: A pilot study
Authors: Kanti Varvara , Günther Malise , Stroux Andrea , Sawatzky Sabine , Henrich Wolfgang , Abou‐Dakn Michael , Blume‐Peytavi Ulrike , Garcia Bartels Natalie 
Published: January 2017

SummaryBackgroundSkin care influences skin barrier function during the first postnatal weeks. Although the use of natural oils in preterms has been investigated, there are currently no data comparing the effect of sunflower oil to an emollient on barrier development in healthy term newborns.MethodsIn a prospective, randomized clinical study, 50 healthy full‐term newborns aged ≤72 h were randomly assigned to two groups: group baby lotion (L, n=22) and sunflower seed oil (SSO, n=24). The skin barrier function was evaluated in three anatomical areas (front, abdomen, and thigh) by noninvasive assessment of transepidermal water loss (TEWL), stratum corneum hydration (SCH), sebum, and skin pH at inclusion and after five weeks.ResultsIn both groups, skin pH decreased and SCH increased statistically significantly in all measured areas at W5 compared to baseline. TEWL decreased statistically significantly on the forearm in both groups, on the upper leg in group L, and on the abdomen in group SSO.ConclusionsBoth skin care regimes did not harm skin barrier function adaptation in healthy term neonates during the first five weeks of life.
Life after a lung transplant: a balance of joy and challenges
Authors: Graarup Jytte , Mogensen Elin Lindberg , Missel Malene , Berg Selina Kikkenborg 
Published: January 2017

Aim and objectiveTo describe patients’ experiences throughout the first four months post‐lung transplant.BackgroundHealth professionals are familiar with the fact that patients’ average survival after a lung transplant is about seven years and that 74% of these patients reject new organs within the first two years. By contrast, knowledge of these patients’ perspectives after lung transplantation is scant.Design/MethodA qualitative study was conducted between May 2013–May 2014 in which 26 interviewees participated – four months post‐transplant – based on a semistructured interview guide. The data were inductively analysed using a content thematic approach within a phenomenological and hermeneutic frame.ResultsThe main findings in the study reveal that (1) having a lung transplant is an overwhelming experience, which for some patients includes (2) troubling physical and psychological challenges. The interviewees were happy to get another chance to live, although some of them suffered from medical side effects, postoperative complications and psychological problems. When asked about the future, interviewees stated that life could be described as (3) a balance of joy and challenges. They had received a new chance in life and were eager to fulfil their life hopes and dreams. At the same time, they were worried about the future. Having a lung transplant implies rules that have to be followed. What are the healthy choices they are supposed to make? And will there be a tomorrow?ConclusionsHaving a lung transplant is described as an overwhelming experience because of the improvement in the physical function of the body. Patients were grateful to family, friends and healthcare professionals for supporting them. The first four months post‐transplantation were described as both physically and psychologically challenging. Interviewees were aware of the prognosis for patients following lung transplantation. They expressed feelings of worry and insecurity but still had hopes and dreams.Relevance to clinical practiceThe patients are troubled by both physical and psychological challenges after lung transplantation. Several areas call for interventions from healthcare professionals during the early post‐transplant period.
Sleep duration and obesity in children: A systematic review and meta‐analysis of prospective cohort studies
Authors: Li Lian , Zhang Shuang , Huang Yubei , Chen Kexin 
Published: January 2017

AimChildhood obesity is a major public problem worldwide, and sleep duration may be associated with childhood obesity. We conducted a systematic review and meta‐analysis of prospective cohort studies to estimate the associations between sleep duration and obesity/body mass index (BMI) in children.Methods
PubMed, Embase and the Cochrane Library were searched. For the meta‐analysis, the pooled relative risk (RR) and 95% confidence intervals (CI) were estimated to reveal the association between short sleep duration and obesity. For the review, the outcomes focused on BMI change or subsequent BMI status.ResultsA total of 12 studies (15 populations) met the criteria for inclusion in the meta‐analysis. Short sleep duration was significantly associated with obesity (RR: 1.45; 95% CI: 1.14–1.85). After excluding two cohorts that substantially affected the heterogeneity, the pooled results remained significant (RR: 1.30; 95% CI: 1.20–1.42), and the association was not substantially altered in the subgroup analysis. In addition, we summarised 24 studies that met the criteria for our review of the relationship between sleeping and BMI.ConclusionThe present meta‐analysis indicated that short sleep duration increased the risk of childhood obesity. Public health efforts that encourage children to have sufficient sleep time may be important in combating obesity.
Parental perceptions of clown care in paediatric intensive care units
Authors: Mortamet Guillaume , Merckx Audrey , Roumeliotis Nadia , Simonds Caroline , Renolleau Sylvain , Hubert Philippe 
Published: January 2017

AimThe objective of this study was to report family satisfaction with regards to the presence of clowns in the paediatric intensive care unit (PICU).MethodsThis is a single‐centre survey‐based study, conducted over 4 months in a 12‐bed third level PICU in a university hospital. All parents present at the bedside of their child during clowning were considered as potential participants. Eligible parents were approached by one of the two intensivists as investigators and asked to complete a survey within the 48 h following the clowns’ intervention.ResultsThirty‐three parents consented to complete the survey. Median age of children was 14 months (15 days to 16 years) and median Pediatric Logistic Organ Dysfunction (PELOD) score was 1 (0–22). Twenty‐four (72.7%) were considered as clinically stable while the clowns intervened. Twenty‐eight parents (84.8%) and 27 (81.8%) considered that clowns had a positive effect on themselves and on their child, respectively. Clown care was considered as necessary in 19 cases (57.6%), optional in 13 (39.4%) and unnecessary in 1 (3.0%). The degree of parental satisfaction was not significantly associated with the child's clinical stability.ConclusionWe suggested that medical clowning in the PICU is well accepted by parents, regardless of severity of their child's condition. This study supports the adoption of medical clowning in PICUs as a patient‐ and family‐centred care practice.
What our eyes tell us about feelings: Tracking pupillary responses during emotion regulation processes
Authors: Kinner Valerie L. , Kuchinke Lars , Dierolf Angelika M. , Merz Christian J. , Otto Tobias , Wolf Oliver T. 
Published: January 2017

AbstractEmotion regulation is essential for adaptive behavior and mental health. Strategies applied to alter emotions are known to differ in their impact on psychological and physiological aspects of the emotional response. However, emotion regulation outcome has primarily been assessed via self‐report, and studies comparing regulation strategies with regard to their peripheral physiological mechanisms are limited in number. In the present study, we therefore aimed to investigate the effects of different emotion regulation strategies on pupil dilation, skin conductance responses, and subjective emotional responses. Thirty healthy females were presented with negative and neutral pictures and asked to maintain or up‐ and downregulate their upcoming emotional responses through reappraisal or distraction. Pupil dilation and skin conductance responses were significantly enhanced when viewing negative relative to neutral pictures. For the pupil, this emotional arousal effect manifested specifically late during the pupillary response. In accordance with subjective ratings, increasing negative emotions through reappraisal led to the most prominent pupil size enlargements, whereas no consistent effect for downregulation was found. In contrast, early peak dilations were enhanced in all emotion regulation conditions independent of strategy. Skin conductance responses were not further modulated by emotion regulation. These results indicate that pupil diameter is modulated by emotional arousal, but is initially related to the extent of mental effort required to regulate automatic emotional responses. Our data thus provide first evidence that the pupillary response might comprise two distinct temporal components reflecting cognitive emotion regulation effort on the one hand and emotion regulation success on the other hand.
The impact of salience and visual working memory on the monitoring and control of saccadic behavior: An eye‐tracking and EEG study
Authors: Weaver Matthew D. , Hickey Clayton , van Zoest Wieske 
Published: January 2017

AbstractIn a concurrent eye‐tracking and EEG study, we investigated the impact of salience on the monitoring and control of eye movement behavior and the role of visual working memory (VWM) capacity in mediating this effect. Participants made eye movements to a unique line‐segment target embedded in a search display also containing a unique distractor. Target and distractor salience was manipulated by varying degree of orientation offset from a homogenous background. VWM capacity was measured using a change‐detection task. Results showed greater likelihood of incorrect saccades when the distractor was relatively more salient than when the target was salient. Misdirected saccades to salient distractors were strongly represented in the error‐monitoring system by rapid and robust error‐related negativity (ERN), which predicted a significant adjustment of oculomotor behavior. Misdirected saccades to less‐salient distractors, while arguably representing larger errors, were not as well detected or utilized by the error/performance‐monitoring system. This system was instead better engaged in tasks requiring greater cognitive control and by individuals with higher VWM capacity. Our findings show that relative salience of task‐relevant and task‐irrelevant stimuli can define situations where an increase in cognitive control is necessary, with individual differences in VWM capacity explaining significant variance in the degree of monitoring and control of goal‐directed eye movement behavior. The present study supports a conflict‐monitoring interpretation of the ERN, whereby the level of competition between different responses, and the stimuli that define these responses, was more important in the generation of an enhanced ERN than the error commission itself.
Nasopharyngeal carriage of respiratory pathogens in Warao Amerindians: significant relationship with stunting
Authors: Verhagen Lilly M. , Hermsen Meyke , Rivera‐Olivero Ismar A. , Sisco María Carolina , de Jonge Marien I. , Hermans Peter W. M. , de Waard Jacobus H. 
Published: January 2017

AbstractObjectiveTo assess risk factors for nasopharyngeal carriage of potential pathogens in geographically isolated Warao Amerindians in Venezuela.MethodsIn this point prevalence survey, nasopharyngeal swabs were obtained from 1064 Warao Amerindians: 504 children aged 0–4 years, 227 children aged 5–10 years and 333 caregivers. Written questionnaires were completed to obtain information on demographics and environmental risk factors. Anthropometric measurements were performed in children aged 0–4 years.ResultsCarriage rates of Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae and Moraxella catarrhalis were 51%, 7%, 1% and 13%, respectively. Crowding index, method of cooking and tobacco exposure were not associated with increased carriage. In multivariable analysis, an increase in height‐for‐age Z score (i.e. improved chronic nutritional status) was associated with decreased odds of S. pneumoniae colonisation (OR 0.76, 95% CI 0.70–0.83) in children aged 0–4 years.ConclusionsBetter knowledge of demographic and environmental risk factors facilitates better understanding of the dynamics of colonisation with respiratory bacteria in an Amerindian population. Poor chronic nutritional status was associated with increased pathogen carriage in children <5 years of age. The high rates of stunting generally observed in indigenous children may fuel the acquisition of respiratory bacteria that can lead to respiratory and invasive disease.
Reviewer Acknowledgements
Authors: Gibbs Nikki 
Published: January 2017

Applied Economics and Finance (AEF) would like to thank the following reviewers for reviewing manuscripts from September 15, 2013, to April 30, 2014. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Many authors, regardless of whether AEF publishes their work, appreciate the helpful feedback provided by the reviewers. Redfame Publishing appreciates the following reviewers’ rigorous and conscientious efforts for this journal. Each of the reviewers listed below returned at least one review during this period. Ioannis Bournakis Ramona Orastean Steven V. Cates Patrycja Kowalczyk-Rólczynska Haitham Nobanee George Theocharides Shahram Fattahi Vilas Gaikar Jolita Vveinhardt Jin Yong Yang Eyup Dogan Ian McFarlane Marta Borda Y. SAIDI Blen Solomon
Reviewer Acknowledgements
Authors: Gibbs Nikki 
Published: January 2017

Applied Economics and Finance [AEF] would like to thank the following reviewers for reviewing manuscripts from January 30, 2015, to July 31, 2015. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Many authors, regardless of whether AEF publishes their work, appreciate the helpful feedback provided by the reviewers. Redfame Publishing appreciates the following reviewers’ rigorous and conscientious efforts for this journal. Each of the reviewers listed below returned at least one review during this period. Eyup Dogan Farhat Iqbal Getamesay Bekele Ghazi Al-Assaf Haitham Nobanee Ian McFarlane Jin Yong Yang Magdalena Zioło Marta Borda Ramona Orastean Shahram Fattahi Steven V. Cates Szabolcs Blazsek Uwuigbe, Olubukunola Ranti Vilas Gaikar Vilas Gaikar Y. SAIDI Yao Zheng Nikki Gibbs Editorial Assistant On behalf of, The Editorial Board of Applied Economics and Finance Redfame Publishing 9450 SW Gemini Dr. #99416 Beaverton, OR 97008, USA URL: http://aef.redfame.com
Reviewer Acknowledgements
Authors: Gibbs Nikki 
Published: January 2017

Applied Economics and Finance [AEF] would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether AEF publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 4, Number 1 Aaron MoreyAndrey KudryavtsevArash RiasiAyoub Taha SidahmedByson Beracah MajangaEyup KadiogluFarhat IqbalGetamesay BekeleIan McFarlaneIgor MatyushenkoJin Yong YangJolita VveinhardtLuca GiordanoMagdalena RadulescuMagdalena ZiołoMarta BordaMevlut TatliyerMohammed Alkali YusufPatrycja Kowalczyk-RólczynskaPayal ChadhaProf. Ali MassoudRamona OrasteanSeyyed Ali Zeytoon Nejad MoosavianSteven V. CatesSzabolcs BlazsekTaro AbeY. Saidi Nikki GibbsEditorial AssistantOn behalf of,The Editorial Board of Applied Economics and FinanceRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://aef.redfame.com
Reviewer Acknowledgements
Authors: Evelyn Angelia 
Published: January 2017

Applied Finance and Accounting [AFA] would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether AFA publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 2, Number 2 Anastasia, Kopaneli Arash Riasi Ejaz Gul Florin Peci Gheorghe Morosan Ioan Bogdan Robu James Estes Juan Fernando Henao Duque Luo Yongli Marco Muscettola Mawih Kareem Al Ani, Meri Boshkoska Mohamed Jalloh Nicoleta Radneantu Noriaki Okamoto Odumeso-Jimoh M I John Peibiao Zhao Vineet Chouhan Angelia Evelyn Editorial Assistant On behalf of, The Editorial Board of Applied Finance and Accounting Redfame Publishing 9450 SW Gemini Dr. #99416 Beaverton, OR 97008, USA E-mail: afa@redfame.com URL: http://afa.redfame.com
Reviewer Acknowledgements
Authors: Young James 
Published: January 2017

International Journal of Social Science Studies (IJSSS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether IJSSS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 4, Number 11 Abdul Azim Akhtar Anastasia Panagakos António Calha E.Ozan AKSÖZ Julia M. Mack K.O. Aramide Katja Eman Małgorzata Haładewicz Oluwagbemiga Paul Agboola Priyono Rachita Shrivastava Roy Rasa Poceviciene Raymond Chan Sandro Serpa Zafer İBRAHİMOĞLU James Young Editorial Assistant On behalf of, The Editorial Board of International Journal of Social Science Studies Redfame Publishing 9450 SW Gemini Dr. #99416 Beaverton, OR 97008, USA URL: http://ijsss.redfame.com