bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodology for developing and validating Bangladesh healthy eating index: A study protocol
Authors: Jubayer Ahmed , Nowar Abira , Islam Saiful , Islam Md. Hafizul , Nayan Md. Moniruzzaman 
Published: October 2024

BackgroundOne of the widely used methods for evaluating the overall quality of a diet is the Healthy Eating Index. In the present study protocol, we lay out the methodological approach to the development and validation of a healthy eating index specific for the Bangladeshi population (hereinafter referred to as Bangladesh Healthy Eating Index (BD-HEI)).MethodsBangladesh Healthy Eating Index will be developed based on the Food-based dietary guidelines (FBDG) of Bangladesh. Using a scoring system that aligns with the eleven food groups outlined in the FBDG, the index will consist of eleven eating components. A cross-sectional community nutrition survey will be carried out among 1080 reproductive-aged women. Through this survey, quantitative dietary data will be collected following multiple pass 24h dietary recall method. Repeated 24-hour dietary data (of two consecutive days) will be collected from one-third of the respondents. Evaluating usual food and nutrient intake as well as the probability of nutrient intake adequacy, the study will examine the validity of the BD-HEI. Following a suitable statistical procedure, the reliability and construct validity of BD-HEI will be evaluated.Significance of the studyCountry-specific HEI can be used to assess the dietary quality of the people of that country. The findings from this research can inform policy decisions and strategies to promote healthier eating habits and combat the rising burden of diet-related diseases in the country.
A human cadaveric model for venous air embolism detection tool development
Authors: Robinson Nathaniel L. , Marcellino Chris , Johnston Matthew , Abcejo Arnoley S. 
Published: October 2024

Purpose
A human cadaveric model combining standard lung protective mechanical ventilation and modified cardiac bypass techniques was developed to allow investigation into automated modes of detection of venous air emboli (VAE) prior to in vivo human or animal investigations.

Methods
In this study, in order to create an artificial cardiopulmonary circuit in a cadaver that could mimic VAE physiology, the direction of flow was reversed from conventional cardiac bypass. Normal saline was circulated in isolation through the heart and lungs as opposed to the peripheral organs by placing the venous cannula into the aorta and the arterial cannula into the inferior vena cava with selective ligation of other vessels.

Results
Mechanical ventilation and this reversed cardiac bypass scheme allowed preliminary detection of VAE independently but not in concert in our current simulation scheme due to pulmonary edema in the cadaver. A limited dissection approach was used initially followed by a radical exposure of the great vessels, and both proved feasible in terms of air signal detection. We used electrical impendence as a preliminary tool to validate detection in this cadaveric model however we theorize that it would work for echocardiographic, intravenous ultrasound or other novel modalities as well.

Conclusion
A cadaveric model allows monitoring technology development with reduced use of animal and conventional human testing.
Diffuse white matter pathology in multiple sclerosis during treatment with dimethyl fumarate—An observational study of changes in normal-appearing white matter using proton magnetic resonance spectroscopy
Authors: Tisell Anders , Söderberg Kristina , Link Yumin , Lundberg Peter , Mellergård Johan 
Published: October 2024

Background
Multiple sclerosis (MS) is an inflammatory demyelinating disease with neurodegenerative features causing risk for neurologic irreversible disability over time. Examination of normal-appearing white matter (NAWM) changes in MS by proton magnetic resonance spectroscopy (1H-MRS), may detect diffuse white matter pathology that is associated with neurodegeneration.

Methods
In this observational study of in total twenty-six patients with MS, starting treatment with dimethyl fumarate (DMF), we measured the absolute concentration of metabolites in periventricular NAWM using 1H-MRS at baseline and after one and three years of treatment. Metabolite concentrations were analyzed both cross-sectionally, in relation to 10 controls and longitudinally in relation to disease activity.

Results
Patients with MS had higher concentrations of myo-inositol (mIns) in NAWM at baseline compared with controls (mean 5.98 ± 1.37 (SD) and 4.32 ± 1.16 (SD), p<0.01, independent samples t-test). The disease duration was inversely correlated with concentrations of total N-acetylaspartate and N-acetylaspartylglutamate (tNA) (r = -0.62, p<0.01) in NAWM as well as positively to the ratio of mIns and tNA (r = 0.51, p = 0.03). Metabolite concentrations during one-year (n = 19) and three-years (n = 11) follow-up were generally stable. The dropouts were caused by treatment switch after one year, mainly due to new MRI activity. Cross-sectional analyses showed that there was an inverse correlation between concentrations of tNA and mIns at both baseline and at 1 and 3-years follow-up (r = -0.44 to -0.65, p = 0.04 to 0.004). Metabolite concentrations were stable during 1-year follow-up independently of disease activity.

Conclusions
Higher concentrations of the astrogliosis marker mIns in MS compared to controls, the inverse relation between MS disease duration and the neuroaxonal integrity marker tNA, as well as the consistent inverse relation between these two metabolites during follow-up, showed that non-lesional white matter pathology is present in this cohort of MS patients in early disease stages. However, metabolite concentrations during follow-up were generally stable and did not reflect differences in disease activity among patients.
Evaluation of transcutaneous electrical acupoint stimulation for improving pain and cognitive function in elderly patients around the perioperative period of hip replacement surgery: A meta-analysis
Authors: Xu Sujuan , Huang Kai , Jiang Qing 
Published: October 2024

Purpose
We aim to evaluate the efficacy and safety of transcutaneous electrical acupoint stimulation(TEAS) in elderly patients around the perioperative period of hip replacement surgery.

Methods
The China National Knowledge Infrastructure(CNKI), Wangfang Data, VIP database, SinoMed, PubMed, and Embase databases were searched for relevant publications until August 2024. All randomized controlled studies evaluating the efficacy and safety of TEAS in patients around the perioperative period of hip replacement surgery. We calculated pooled risk ratio (RR) with 95% CIs for binary outcomes and standardized mean difference (SMD) for continuous outcomes. The Cochrane’s Risk of Bias Tool were used to evaluate the quality of studies.

Results
A total of 13 studies with 946 patients were included in this analysis. 1-day visual analogue scale (VAS) scores and 2-day VAS scores were significantly lower in the TEAS group compared to the control group (SMD: -0.78, 95% CI: -1.47, -0.09, P = 0.02 and SMD:-0.54, 95% CI:-1.00,-0.09,P = 0.02). Furthermore, 1-day mini-mental state examination (MMSE) scores and 3-day MMSE scores were significantly higher in the TEAS group compared to the control group (SMD: 1.60, 95% CI: 0.68, 2.51,P<0.001 and SMD:1.31, 95% CI:1.03,1.59,P<0.001), along with a lower postoperative cognitive dysfunction rate (RR: 0.55, 95% CI: 0.41, 0.73, P<0.001).

Conclusions
Our meta-analysis demonstrated that TEAS significantly reduces pain and improves cognitive function in patients undergoing hip replacement surgery. Future studies should further investigate the optimal TEAS protocols to maximize these benefits across different population and surgical settings.
Addressing bladder and bowel challenges in dutch multiple sclerosis patients: Symptom prevalence and patient referral pathways
Authors: Faber Willemijn , Stillebroer Alexander B. 
Published: October 2024

Objectives
Nerve damage and/or spinal cord injury in individuals with multiple sclerosis (MS) may result in the development of bladder and bowel problems. We wanted to gain insight into two issues: the prevalence of bladder and bowel problems among individuals with MS and the referral pathways for these problems to various physicians treating patients with MS.

Methods
In the autumn of 2021, we undertook a nationwide cross-sectional study. We used a comprehensive questionnaire comprising 63 questions covering aspects such as MS diagnosis, disease progression, bladder and bowel issues, and consultations with healthcare professionals. Individuals with MS were invited to participate through social media or by direct mail.

Results
The study included 1,082 validated respondents (81.5% female) with an average age of 53.3 years at participation, and an average age of 38.3 years at MS-diagnosis. Among the respondents, 91% experienced bladder problems while 73% indicated they had bowel problems. Within these respective groups, 42% and 47% were not aware of the connection between these issues and MS. Bladder and bowel related complaints disrupted daily life for 45% and 28% of the respondents, respectively. The patients consulted various healthcare providers for their complaints. Most respondents expressed dissatisfaction with the time it took to resolve their problems and 9% of those with bladder complaints and 60% of those with bowel complaints had not yet found a satisfactory solution.

Conclusions
In the Netherlands, bladder and bowel symptoms in individuals with MS are highly prevalent and have a considerable impact on quality of life. Lack of awareness of these symptoms frequently leads to inadequate recognition, both by the patient and healthcare professional. Patients often consult various healthcare professionals for these complaints, which can potentially result in suboptimal treatment due to a lack of specialized expertise.
Is human albumin injection the best choice to treat hypoalbuminemia?
Authors: Shi Yingqin , Song Hai , Fang Lingzhi , Wu Fuxi , Qiu Bo , Tian Dongdong , Liu Caixia , Di Hailing 
Published: October 2024

Background
Currently, there is an irrational use of drugs in the treatment of hypoproteinemia. This study evaluates the value of 12 injections to provide a basis for drug selection for the treatment of hypoproteinemia.

Methods
The content of the first restrictive amino acid, the comprehensive quality of the total essential amino acid, and the closeness to the whole egg protein or FAO/WHO model were evaluated to compare their value in the amino acid synthesis of human serum albumin. A comparison was made between the matching degree of HA and therapeutic amino acids with the human plasma amino acid profile. Furthermore, the value and safety of synthetic human serum albumin were compared.

Results
The lowest synthetic value of human serum albumin was 18AA-V, and the highest was 18AA-II. The CS values of HA, 18AA-V, 18AA-II, 18AA-Ip, 18AA-IIp, and 19AA-Ip were 0.18, 0.58, 0.78, 0.55, 0.54, and 0.59, respectively. The similarity to egg protein was 0.81, 0.92, 0.94, 1.00, 1.18, and 1.18, respectively. The proximity values to FAO/WHO standards were 0.81, 0.85, 0.90, 1.36, 1.54, and 1.54, respectively. The changes in 3AA and the amino acid profile were matched when liver function was abnormal. When the renal function was abnormal, 9AA was matched. During trauma, 18AA-VII was matched. The amino acid profile of HA did not correspond.

Conclusion
Patients with normal liver and kidney function should choose compound balanced amino acid injection, while patients with abnormalities should choose 3AA. Patients with renal dysfunction should choose 9AA. Trauma patients should choose 18AA-VII.
Acute and chronic impact of interleukin-33 stimulation on chemokines and growth factors in human cord blood-derived mast cells
Authors: Bakhashab Sherin , Banafea Ghalya H. , Ahmed Farid , Alsolami Reem , Schulten Hans-Juergen , Gauthaman Kalamegam , Naseer Muhammad Imran , Pushparaj Peter Natesan 
Published: October 2024

Background
Mast cells (MCs) are multifaceted immune cells that are capable of recognizing and responding to various stimuli by releasing an array of cytokines. We aimed to use human cord blood-derived mast cells (hCBMCs) as a model to evaluate different conditions under which chemokines and growth factors are expressed and secreted as mediators upon stimulation with the alarmin interleukin-33 (IL-33).

Methods
hCBMCs were stimulated with 10 ng/mL or 20 ng/mL of recombinant human IL-33 (rhIL-33) for 6 h (acute) or 24 h (chronic). The mRNA expression of chemokines and growth factors was analyzed using microarrays, and the mediators released in the supernatant were evaluated using a multiplex assay.

Results
The mRNA expression levels of C-C chemokine ligands (CCL) CCL1, CCL5, granulocyte macrophage colony-stimulating factor (GM-CSF), and macrophage inflammatory protein (MIP)-4/CCL18 were upregulated under all conditions. In contrast, C-X-C motif chemokine ligand (CXCL) CXCL8 and CCL24 levels increased only under acute (6 h) and prolonged (24 h) conditions, respectively. Moreover, high levels of CXCL8, MIP-1α, and MIP-1β were secreted during acute inflammation, whereas the release of GM-CSF and CXCL9 proteins increased under all four conditions.

Conclusions
This study highlights the sentinel role of MCs in mounting a specific immune response against a pathogenic-like stimulus in a timely and dose-dependent manner and is relevant for improving inflammatory treatment options.
A (in)fluência do Tractatus de Wittgenstein no pensamento Hadotiano da filosofia como modo de vida
Authors: Batista Lopes de Oliveira Rafael 
Published: October 2024

Resumo: Pierre Hadot apresenta Wittgenstein como um dos filósofos que o ajudou na sua concepção de filosofia como modo de vida e como um exemplo da persistência dela para além da filosofia antiga. Assim, neste artigo, apresentamos o teor dessa (in)fluência pela obra Tractatus Logico-Philosophicus - obra situada na primeira fase do pensamento do austríaco. Para isso, esperamos mostrar, no primeiro capítulo, a leitura hadotiana da obra e, no segundo, suas recusas e aceitações a ela. Com isso, oferecemos uma ampliação do debate acerca do que é o escrito tractatiano e alguns pormenores daquele conceito do francês que marca o debate sobre o que consiste a filosofia e sua história.
Palavras-chave: Pierre Hadot; Filosofia como Modo de Vida; Wittgenstein; Tractatus Logico-Philosophicus
The (in)fluence of Wittgenstein's Tractatus in Hadotian thought of philosophy as a way of life
Abstract: Pierre Hadot presents Wittgenstein as one of the philosophers who helped him in his conception of philosophy as a way of life and as an example of its persistence beyond ancient philosophy. Therefore, in this article, we present the content of this (in)fluence on the work Tractatus Logico-Philosophicus - a work located in the first phase of the Austrian's thought. To this end, we hope to show, in the first chapter, the Hadotian reading of the work and, in the second, his refusals and acceptances of it. With this, we offer an expansion of the debate about what tractatian writing is and some details of that French concept that marks the debate about what philosophy and its history consist of.
Keywords: Pierre Hadot; Philosophy as a Way of Life; Wittgenstein; Tractatus Logico-Philosophicus

Data de registro: 26/02/2024
Data de aceite: 09/07/2024
Typical clinical practice of treating patients with chronic migraine
Authors: Golovacheva V. A. , Golovacheva A. A. , Tarshilova A. R. , Osipova V. V. 
Published: October 2024

Currently, effective methods for the treatment of chronic migraine (CM) have been developed, but it remains unclear how they are used in real clinical practice and how often. The typical practice of treating patients with CM in our country has not been sufficiently investigated, which formed the basis for conducting this study.Objective: to evaluate the quality of treatment of patients with CM in real-life neurological practice.Material and methods. The study included 200 patients with CM (63 men and 137 women, mean age – 33.1±7.1 years) admitted to A.Ya. Kozhevnikov Clinic of Nervous Diseases (CND) of Sechenov University for frequent headaches, who were previously treated by neurologists in other medical institutions on an outpatient and/or inpatient basis. All patients were clinically interviewed to establish a diagnosis and analyze their previous treatment.Results. All patients had an experience of incorrect or inadequate treatment, including ineffective drug and non-drug methods. All patients were taking painkillers to relieve migraine, but less than half of them was satisfied with their effectiveness. Only 12 (8.5%) patients with medication overuse headache had previously received treatment for drug overuse. None of the patients who were admitted to CND had previously received cognitive-behavioral therapy and treatment with an interdisciplinary approach that included not only pharmacotherapy but also psychological and behavioral methods and kinesiotherapy.Conclusion. In real-life clinical practice, ineffective methods are often used to treat migraine, and an interdisciplinary approach that includes effective pharmacotherapy and non-pharmacological methods is lacking.
Analysis of migraine characteristics in postmenopausal women
Authors: Klimentova D. A. , Kosivtsova O. V. , Sergeev A. V. , Tabeeva G. R. 
Published: October 2024

Objective: to identify characteristics of migraine in women in postmenopause (PM) by analyzing the frequency, duration and intensity of migraine attacks, assessment of quality of life, anxiety, depression and sleep disturbances in patients in the reproductive phase (RP) and in the PM.Material and methods. The study comprised 60 migraine patients (30 patients in the RP, 30 patients in the PM). During the personal interview, age, migraine type, frequency and duration of attacks and headache (HA) intensity on the visual analogue scale (VAS) were recorded. The patients then completed the questionnaires: HIT-6, MIBS-4, HURT, Migraine- ACT, MIDAS, SF-36, HADS, ISQ. The statistical analysis was performed in Microsoft Office Excel 2021.Results. The risk of high intensity HA (≥8 points on the VAS) was significantly higher in patients in the PM than in patients in the RP [p<0.05; relative risk (RR) 1.77]. The risk of necessity of a revision of therapy of attacks was higher in the PM than in the RP (p=0.004; RR=2.2). The risk of insomnia was higher in the PM than in the RP (p=0.004; RR=4.67). The risk of severe headache impact (HIT-6) and high migraine burden (MIBS-4) was higher in patients in the PM than in the RP (ORHIT6=1.7; ORMIBS4=1.78). All indicators of SF-36 quality of life questionnaire were significantly lower in patients in the PM group than in the RP group (p<0.05). The risk of subclinical and clinical anxiety (p<0.05; RR=4.33) and depression (p<0.05; RR=2.75) was significantly higher in the PM than in the RP.Conclusion. Migraine attacks in women in the PM are more intense than in women in the RP, quality of life is lower, and revision of therapy for attacks is required more frequently. Patients with migraine in the PM are more likely to suffer from anxiety, depression and insomnia. Further research is needed to determine the causes of the observed phenomena and to develop migraine therapy in patients in the PM.
Going with the flow: New insights regarding flow induced K+ secretion in the distal nephron
Authors: Lasaad Samia , Nickerson Andrew J. , Crambert Gilles , Satlin Lisa M. , Kleyman Thomas R. 
Published: October 2024

AbstractK+ secretion in the distal nephron has a critical role in K+ homeostasis and is the primary route by which K+ is lost from the body. Renal K+ secretion is enhanced by increases in dietary K+ intake and by increases in tubular flow rate in the distal nephron. This review addresses new and important insights regarding the mechanisms underlying flow‐induced K+ secretion (FIKS). While basal K+ secretion in the distal nephron is mediated by renal outer medullary K+ (ROMK) channels in principal cells (PCs), FIKS is mediated by large conductance, Ca2+/stretch activated K+ (BK) channels in intercalated cells (ICs), a distinct cell type. BK channel activation requires an increase in intracellular Ca2+ concentration ([Ca2+]i), and both PCs and ICs exhibit increases in [Ca2+]i in response to increases in tubular fluid flow rate, associated with an increase in tubular diameter. PIEZO1, a mechanosensitive, nonselective cation channel, is expressed in the basolateral membranes of PCs and ICs, where it functions as a mechanosensor. The loss of flow‐induced [Ca2+]i transients in ICs and BK channel‐mediated FIKS in microperfused collecting ducts isolated from mice with IC‐specific deletion of Piezo1 in the CCD underscores the importance of PIEZO1 in the renal regulation of K+ transport.
FIB/SEM serial sectioning as a versatile tool for microstructural analysis
Authors: Engstler M. , Mücklich F. 
Published: October 2024

Abstract
FIB/SEM tomography is a serial sectioning method in which the cross-sectional area of the sample is stepwise removed with a focused ion beam (FIB) and the exposed cross-sectional area is imaged with a scanning electron microscope (SEM). All imaging techniques of the SEM can be used, which allows the application to a wide range of materials science questions. On the one hand, resolutions of a few nm can be achieved, and on the other hand, volumes with edge lengths of 100 μm and more can be examined. This article gives an overview of the current state of the art and the practical implementation of FIB/ SEM serial sectioning. The special aspects of the integration of energy dispersive X-ray spectroscopy (EDS) and electron backscatter diffraction (EBSD) are also discussed.
Toxicity and environmental aspects of surfactants
Authors: Lu Ming , Zhang Guoyin , Holmberg Krister 
Published: October 2024

Abstract
As the single largest class of specialty chemicals, surfactants are consumed in huge quantities in our daily life and in many industrial areas. In the past, the attention was focused entirely on technical performance. However, starting from the 1970s and 80s, surfactant related environmental concerns have become the main driving force to upgrade surfactant production technology to make more benign or “greener” products. For this reason, environmental issues, dermatological effects, and oral toxicity are the main priorities when surfactants are considered for a specific purpose. In this paper, we present five cases to demonstrate how the surfactant industry tackles these challenges to mitigate the environmental and health effects associated with surfactant consumption. We also discuss the important role played by surfactants in a current carbon capture and storage (CCS) strategy to reduce the CO2 level in the atmosphere. Surfactant-based stable CO2 foam flooding is a well-established enhanced oil recovery technique. It has been considered to be an economically realistic procedure to sequester large amounts of CO2 in geological formations.
Muscular Hypertrophy and its Relation to Strength Performance: A Physics-Based Analysis of Conceptual Inaccuracies
Authors: Puschkasch-Möck Sebastian 
Published: October 2024

ABSTRACT
The interchangeable use of terms such as muscle mass, volume, cross-sectional area, and thickness in discussions on the physiology of muscle hypertrophy has led to misconceptions in research and practice. This review aims to highlight the improperness of this approach and highlights the overlooked parameter of muscular density (MD). The hypothesis is that muscle density acts as a mediator, leading to inevitable muscle enlargement in long-term strength training. It is proposed that research in muscular adaptations to training should implement measures of MD to complement measurements of muscle size. This article aims to refine the understanding of muscular adaptations and optimize training strategies for athletes and fitness enthusiasts.