bluuebunny/crossref_metadata_2025_split huggingface dataset:
Troitskosavsk Public Library Visitors’ Reading Fiction in the Late 19th and Early 20th Centuries
Authors: Timofeeva Yu. V. 
Published: October 2024

Lack of comprehensive records on the history of reading in Siberian cities’ libraries, scanty and brief references to reading fiction by the Troitskosavsk Public Library visitors condition the novelty of the declared topic. The purpose of the article is to determine the place of fiction in the reading circle of the Troitskosavsk Public Library visitors in the late XIX – early XX centuries. Methods of comparative analysis, statistical and source study became the main ones when exploring the topic. The source base of the study was 18 reports about the work of the library for 23 years (1887–1909), starting from the time of its foundation, and 2 catalogs revealing its collections.For the first time, the share of fiction in the issuance of publications from the library to the house, in general and without periodicals, was calculated. The obtained data reveal that fiction was the main object of readers’ demands. Calculations were made of the total number of issues of books of individual writers and poets for 15 years (1895–1909) and the average per year, basing on which the top 20 of the most popular of domestic and foreign authors within the library visitors were compiled. The first three places in the ranking of Russian writers were taken by L. N. Tolstoy, V. I. Nemirovich-Danchenko, A. K. Sheller-Mikhailov, foreign – M. Reed, J. Verne, G. Emar. Readers gave clear preference to prose works. The works of Russian authors were more often in the library visitors’ demand than foreign ones.The study complements the information already introduced into scientific circulation about reading fiction in pre-revolutionary Siberia, its place in the reading circle of Siberians and their popular authors.
The Great Patriotic War in the Diary Entries of Siberians: the Analysis of Ego-Document Corpus
Authors: Mandrinina L. A. 
Published: October 2024

The purpose of the article is to characterize the documentary stream (DS) of front-line diaries publications of Siberians – participants in the Great Patriotic War (1941–1945). The article shows the place of diaries in source studies and the importance of diary entries for the study of anthropological content and “psychology of war”. It grounds the reasons for the paucity of front-line diaries in comparison with other types of egodocuments (memoirs, letters). For the first time, the documentary stream, consisting of 40 publications of diaries (and about diaries) of Siberians, was identified and completely studied: bibliometric indicators and content characteristics were presented; sites containing full texts of diaries (or their fragments) were identified and their significance was assessed; diaries storage locations were determined.The studied DS provided information about the diaries of 28 Siberians – the ordinary war participants who, for the most part, had civilian professions in the peacetime. An assessment was given to the site “Prozhito”, realizing the project to collect full texts; the need to preserve full texts of diaries was grounded: to identify diaries stored in personal or family archives and transfer them (or copies of them) to state museums and archives; the importance of studying ego-documents about the Great Patriotic War for the goals of education and ­patriotic training was emphasized.
Comparative Research on Laminar Flame Propagation for Four C8 Fuels
Authors: Meng Xin , Liu Shuai , Tian Jing , Li Ruina , Sun Tao 
Published: October 2024

Experimental studies and numerical analyses were conducted to estimate the laminar flame speeds of butyl ether, n-octane, iso-octane, and 1-octene at temperatures of 373 and 443 K and pressures ranging from 0.03 to 0.3 MPa in a constant-volume combustion chamber. Iso-octane had the slowest laminar flame speed whereas butyl ether had the highest. The LLNL model for large hydrocarbons and the Cai model for butyl ether were combined to describe the chemical kinetic mechanism for the test fuels. The simulation data calculated with the constructed model agree with the experimental data. The discrepancies in the laminar flame speeds of the four fuels were clarified from the perspectives of thermodynamics, diffusion, and chemical kinetics. The results reveal that the thermodynamics and chemical kinetics were dominant. Butyl ether had the highest laminar flame speed. This was attributed to it having the highest adiabatic flame temperature and a higher concentration of H and OH radicals, which have a high reactivity in a flame. Iso-octane produces the highest concentration of CH3, which inhibits flame propagation, so that it had the slowest laminar flame speed.
Validation of DASH and QuickDASH for Outcome Assessment of Anatomic Total Shoulder Arthroplasty for Treatment of Advanced Glenohumeral Osteoarthritis
Authors: Covarrubias Oscar , Agaisse Ty , Portnoff Brandon , Hoffman Ryan , Molino Janine , Paxton E. Scott , Green Andrew 
Published: October 2024

Background:
The Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and its abbreviated version, QuickDASH, are commonly used patient-reported outcome measures (PROMs) for the assessment of an upper-extremity disability. Theoretically, they can be used to compare the treatment outcomes of different upper-extremity conditions. Despite increasingly widespread use for some shoulder conditions, these questionnaires have not been rigorously validated for use to assess the outcomes of patients undergoing anatomic total shoulder arthroplasty (aTSA). The objective of this study was to validate the DASH and QuickDASH scores for a longitudinal outcome assessment of patients undergoing aTSA to treat advanced glenohumeral osteoarthritis (GHOA).

Methods:
In this study, 450 patients with a median age of 70.3 years (interquartile range [IQR] width, 11.7 years) were included; 52.4% of the patients were female. The DASH and QuickDASH questionnaires, the American Shoulder and Elbow Surgeons (ASES) score, the Simple Shoulder Test (SST), and the EuroQol-5 Dimensions (EQ-5D) questionnaire were completed preoperatively and at follow-ups of 3 months, 6 to 12 months, and a minimum of 2 years by patients undergoing aTSA. The criterion validity, construct validity, reliability, and responsiveness of the DASH and QuickDASH were assessed.

Results:
The DASH and QuickDASH scores demonstrated moderate to very strong correlations with the ASES scores (ρ = −0.83 to −0.62), SST scores (ρ = −0.73 to −0.55), and EQ-5D scores (ρ = −0.72 to −0.57); minimal floor or ceiling effects; internal consistency (Cronbach alpha > 0.80); and large Cohen d and standardized response means (<1.6) at all time points. Very strong positive correlations were observed between the DASH and QuickDASH scores at all time points (ρ = 0.96 to 0.97).

Conclusions:
The DASH and QuickDASH scores, which are region-specific rather than shoulder-specific, are valid, reliable, and responsive PROMs for the evaluation of patients with advanced GHOA treated with aTSA. Therefore, the DASH and QuickDASH scores can be used to compare the outcomes of aTSA for the treatment of advanced GHOA with the outcomes of treatment of other upper-extremity disorders, potentially facilitating comparative cost-effectiveness and value analysis studies.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
The Relationship between Safety Climate and Job Satisfaction Among Employees in a Tire Manufacturing Company
Authors: Vosoughi Shahram , Shekaftik Soqrat Omari , Arbousara Fatemeh Shabani , Noushabadi Zhaleh Sedghi 
Published: October 2024

Abstract

Background
Job satisfaction influences individuals' motivation to comply with safety regulations and actively participate in safety initiatives. This research aimed to investigate the influence of safety climate on job satisfaction and determine the relative importance of these variables among employees employed in a tire manufacturing organization. Methods: A descriptive-analytical cross-sectional study was conducted with a sample of 280 randomly selected individuals working in a tire manufacturing company in Tehran province, Iran in the year 2018–2019. Simple random sampling was used for this study. The data collection process involved the utilization of Dante's job satisfaction questionnaire and the NOSACQ Nordic Safety climate questionnaire. Data analysis was performed using SPSS software version 29.0 and R programming language version 4.2.2, employing statistical tests including the Kruskal-Wallis test, post-hoc Dunn test, Mann-Whitney test, Spearman correlation test, and Multiple Quantile Regression. Results: The findings revealed that the results of the multiple regression analysis demonstrated a significant relationship between job satisfaction and factors, including the overall safety climate score, history of workplace accidents, and educational status (P < 0.05). Conclusion: These findings undeniably underscore the crucial role of safety climate in influencing employees' job satisfaction levels within the tire manufacturing industry. Future research should delve deeper into the relationship between safety climate and job satisfaction using longitudinal and qualitative methods.
Whole Cancer Cell Vaccine Protects Ovarian Functions in Tumor-bearing Mice through Downregulating CXCL10
Authors: Zhang Dong , Li Cong-Rong , Xie Shi-Ya , Zhang Shu-Ping , Yang Zhixia , Luo Fu-Qiang , Yang Yan-Jie , Wang Qian , Zhou Hong , Guan Yi-Chun , Wei Zhao-Lian , Cao Yun-Xia , Wang Feng-Song , Zhang Cui-Lian 
Published: October 2024

Abstract

Young female patients with cancer are likely to become sub-fertile or infertile even if they ultimately overcome cancer through various therapies. Cancer immunotherapy has recently emerged as a promising novel therapy against cancers with high malignancy and lethality, but it is unclear whether cancer immunotherapy affects female fertility. This study employed MCA205 cell-allotransplanted B6 mice as a model to investigate whether two popular immunotherapies—PD-1 monoclonal antibody (PD-1) therapy and whole cancer cell vaccine (WCV) therapy—affect ovarian function. MCA205 allotransplanted (M) mice exhibited decreased follicle numbers at each stage, decreased proliferation, increased apoptosis, and a decreased oocyte maturation rate. WCV treatment significantly reversed these abnormalities, whereas PD-1 did not. RNA sequencing of the ovaries revealed that multiple differentially expressed genes (DEGs) were involved in inflammation pathways. Furthermore, cytokine microarray characterized CXCL10 with both biggest increment in M group and best rescue in WCV group. Next, CXCL10 antibody Immunoprecipitation in ovarian lysate and liquid chromatography-mass spectrometry (LC-MS) baited the only receptor IL18R1. Furthermore, we found that CXCL10 impaired ovarian function through three pathways: inducing ovarian fibrosis through CXCL10→IL18R1→p-JNK→COL1A1, promoting primordial follicle overactivation through CXCL10→IL18R1→p-AKT, and increasing ovarian inflammation through CXCL10→IL18R1→p-P65. Finally, we rescued the decreased ovarian function in the M group by blocking the CXCL10→IL18R1 pathway with CXCL10 antibody or a CXCL10–IL18R1 interface peptide, CIBB. This study provides mechanical evidence and translational strategies for WCVs to achieve the dual functions of suppressing tumor progression while protecting ovarian function.
Enhanced Gene-Disease Association and Carrier Screening by Homozygous Mutation Carriers: A Study of Genotypes and Clinical Phenotypes in 17 IRD Families with Homozygous Mutations in Northern China
Authors: Fan Xue , Li Zhen , Sha Lingzhi , Sheng Xunlun , Rong Weining 
Published: October 2024

Abstract

In this study, patients with inherited retinal dystrophies (IRDs) who visited Ningxia Eye Hospital from January 2015 to September 2023 were analyzed. Through whole genome exon sequencing (WES) and Sanger verification, 17 probands carrying homozygous mutations were detected. The association between the genotype and clinical phenotype of patients with homozygous variants was analyzed. Among all the patients, 3 patients (17.6%) had a family history of consanguineous marriage, and the onset age of 5 patients(29.41%) was less than 10 years. According to 12 patients (70.59% ), they had the best corrected visual acuity (monocular) < 0.3. 3 were blind, 9 with moderate to severe visual impairment, and 2 with mild visual impairment. 16 homozygous variants were detected on 9 different genes, of which 7 were de novo homozygous variants, including frameshift variants, missense variants, and a copy number variant. These mutations are related to clinical phenotypes such as Usher syndrome type II (USHⅡ), Stargardt disease (STGD), Retinitis Pigmentosa (RP), Leber congenital amaurosis (LCA), and Bardet-Biedl syndrome (BBS) respectively. The results of the study indicate that more than 80% of homozygous variant carriers originated from non-consanguineous families, emphasizing the significance of genetic screening for individuals who lack a family history of consanguineous marriage and no obvious clinical phenotypes, but who may carry genetic pathogenic variants for genetic diseases. Furthermore, analysis of patient genotypes and clinical phenotypes further expanded the spectrum of mutations in pathogenic genes for IRDs and the spectrum of clinical phenotypes for variants in known genes, and identifying couples at high fertility risk and individuals with moderate or greater severity IRDs can provide a basis for genetic counseling, reproductive decision-making, disease prevention, and management.
Significance of intrarenal vascular lesions in Ig A nephropathy prognosis
Authors: Yang Hyeon Tae , Park Tae In , Kim Yong-Jin , Kim Mee-seon , Park Sun-Hee , Lim Jeong-Hoon , Kang Yuna , Kim DongJa , Han Man-Hoon 
Published: October 2024

Abstract

Background
Immunoglobulin A (IgA) nephropathy is the predominant primary glomerulonephritis globally and remains a subject of active research with a focus on understanding its course and prognosis. Although vascular lesions are associated with IgAN, the current histopathological grading systems do not consider intrarenal vascular lesions when predicting patient prognosis. Therefore, this retrospective study, conducted at Kyungpook National University Hospital between October 2016 and December 2021, aimed to elucidate the significance of intrarenal vascular lesions in IgAN by comparing the clinical data of patients with and without such lesions.
Methods
Data of patients with biopsy-confirmed primary IgAN between October 2016 and June 2021 at Kyungpook National University Hospital (Daegu, South Korea) were collected, and their medical records were reviewed. All slides from these 138 cases were independently pathologically reviewed by two nephropathologists (Y. J. K. and M. S. K.) using light microscope. The vascular lesions included in this study were fibrous intimal thickening, arteriolar wall thickening, and arteriolar hyalinosis. All cases were reviewed according to the Oxford Classification of IgA Nephropathy (2016) and Haas classification.
Results
Of the 138 patients, 88 exhibited at least one intrarenal vascular lesion. Patients with arteriolar wall thickening demonstrated a reduced estimated glomerular filtration rate (eGFR), elevated serum creatinine level and urine protein-to-creatinine ratio, an increased proportion of global glomerulosclerosis, and a higher histologic grade of interstitial fibrosis and tubular atrophy at the time of biopsy.
Conclusion
Arteriolar wall thickening in IgAN are associated with reduced eGFR and global glomerulosclerosis. Moreover, reduced eGFR and global glomerulosclerosis are correlated with the progression to end-stage renal disease. Although the direct correlation between vascular lesions and end-stage renal disease is not entirely clear, a marginally significant association (log-rank test, p = 0.06) was observed with arterial wall thickening. This study suggests the potential importance of vascular lesions in the prognosis of IgAN, encouraging further investigation using larger cohort studies to establish a clearer association.
The burden, trends, and risk factors for osteoarthritis in China from 1990 to 2019 and its predictions until 2035
Authors: Zheng Shuai , Chen Jung , Zhong Jiaming , Wang Huajun , Zha Zhengang , Jiao Genlong , Zheng Xiaofei 
Published: October 2024

Abstract

Objective: This research estimated osteoarthritis (OA) disease burden, trends, and risk variables in China from 1990 to 2019 and projected OA burden till 2035.
Methods: From the 2019 Global Burden of Disease (GBD) Study, data on incident cases, prevalence, disability-adjusted life years (DALY), and age-standardized rates (ASR) for OA were retrieved. We used estimated annual percentage change (EAPC) to do trend analysis, while a Bayesian age-period-cohort model was used to forecast OA tends to 2035. Besides, the burden attributed to OA risk factors was also assessed.
Results: The incidence, prevalence and DALY of OA increased 36%, 35%, and 40%, respectively, in China from 1990 to 2019. In China, knee OA was the most widespread, followed by hand OA, and hip OA is the least prevalent. The disease burden of OA was more severe among females than males, with differences in distribution between age groups. The ASIR of OA patients had risen steadily over the last 30 years and was expected to decrease somewhat over the next 15 years. In 2019, all risk variables contributed 12% of OA DALYs. The primary risk variables for OA DALYs were a high body mass index and advancing age.
Conclusion: The disease burden of OA in China has increased steadily over the last 30 years, but this trend will become less prominent or perhaps reverse during the next 15 years. High body mass index (BMI) has gradually emerged as an important factor in the disease burden of OA.
Legume intensification leads to social-ecological win-win outcomes globally
Authors: Cruz Daniel , Archibald Carla , Hazenbosch Mirjam , Casey Elodie , Tulloch Ayesha 
Published: October 2024

Abstract

Despite strong evidence that input-intensified agriculture cannot simultaneously achieve positive outcomes for people and nature, increased synthetic inputs are still supported by many governments. Crop diversification introducing legume intercropping and rotations is increasingly proposed as an alternative to sustainable intensify agri-food production. However, few studies have explored the joint social-ecological impacts of this type of sustainable intensification. We systematically review 382 grain legume intensification cases in 183 studies globally, and find win-win outcomes for nature (ecosystem services and biodiversity) and human well-being in 42% of cases, with a further 41% having predominantly positive outcomes. Unlike input-intensified agriculture, our review demonstrates that social-ecological win–win outcomes in agriculture are possible, and outcomes for economic and non-economic well-being increase when provisioning services and biodiversity are increased. We find clear trade-offs between nature and well-being in only 6% of cases, suggesting that legume diversification is a promising pathway to achieving sustainable development goals.
Early COVID-19 and protection from Omicron in a highly vaccinated population in Ontario, Canada: a matched prospective cohort study
Authors: Shigayeva Altynay , Kandel Christopher , Farooqi Lubna , Zhong Zoe , Gingras Anne-Claude , Coleman Brenda , Gilbert Lois , Gold Wayne L. , Major Maria , Mazzulli Tony , Mubareka Samira , Vojicic Jelena , Yang Jingyan , Zhang Pingping , Martin Catherine , Kyaw Moe H. , McLaughlin John M. , McGeer Allison 
Published: October 2024

Abstract

Objectives: Predictions regarding the on-going burden of SARS-CoV-2, and vaccine recommendations, require an understanding of infection-associated immune protection. We assessed whether early COVID-19 provided protection against Omicron infection.
Methods: We enrolled a cohort of adults in Ontario, Canada, with COVID-19 prior to October 2020 (early infection, EI), and a matched cohort with COVID-19 testing and a negative PCR (non-EI). Participants completed baseline then bi-weekly surveys until January 2023. Multivariable Cox regression was used to assess factors associated with COVID-19 infection during the first 14 months of Omicron.
Results: Overall, 624 EI (70%) and 175 (77%) non-EI participants met criteria for analysis; 590 (95%) EI and 164 (94%) non-EI had received at least 2 COVID-19 vaccine doses prior to Omicron. Of 624 EI, 175 (28%) had one SARS-CoV-2 re-infection and 8 (1.3%) had two, compared to 84 (48%) non-EI participants with one, 5 (2.9%) with two and 1 (0.6%) with 3 infections (P<0.0001). In multivariable analysis of risk factors for Omicron infection, the overall hazard ratio (HR, 95%CI) associated with EI was 0.56 (0.43-0.74); HRs for BA.1/2, BA.4/5 and mixed BA.5/BQ.1/XBB periods were 0.66 (0.45-0.97), 0.44 (0.28-0.68) and 0.71 (0.32-1.56). EI and BA.1/2 infection combined reduced later Omicron infection (HR 0.07 (0.03-0.21) compared to no prior infection. Older age, non-White ethnicity, no children in household, and lower neighbourhood income were associated with reduced risk of infection.
Conclusions: In our highly vaccinated population, early SARS-CoV-2 infection was associated with a 44% reduction in symptomatic COVID-19 during the first 14 months of Omicron. Infection in combination with vaccination appears to provide considerably more durable protection against infection than either alone.
Low-dose ATG/PTCy for graft-versus-host disease prevention in haploidentical transplantation: influences of ATG doses and pre-ATG absolute lymphocyte count
Authors: Li Qingsheng , Hong Jian , Liang Xinglin , Ni Jing , Ruan Min , Long Zhangbiao , Dai Jifei , Liang Li , Yang Mingya , Zhang Shihao , Ge Jian , yang mingzhen 
Published: October 2024

Abstract

The combination of anti-thymocyte globulin (ATG) and post-transplant cyclophosphamide (PTCy) has been administered for graft-versus-host disease (GVHD) prophylaxis of haploidentical transplantation (haplo-HSCT) in recent years. However, the optimal doses of ATG and PTCy are yet to be determined. Here, we report the joint use of low-dose ATG (7.5 or 5 mg/Kg) and PTCy (29 mg/Kg) for GVHD prophylaxis in our center and analyze the impact of different ATG doses and absolute lymphocyte count (ALC) before ATG infusion. Fifty-one consecutive leukemia patients who underwent haplo-HSCT with this regimen were included, with 27 and 24 patients receiving 7.5 and 5.0 mg/Kg ATG, respectively. The 100-day cumulative incidences (CIs) of grade I-IV, II-IV and III-IV acute GVHD were 42.0%, 34.0% and 12.0%, respectively. no significant difference on acute GVHD was observed between two ATG groups. Interestingly, with a cutoff point of 0.585×109/L, low pre-ATG ALC group (18 patients) showed reduced CIs of grade I-IV (16.7% versus 56.3%, p=0.01), II-IV (16.7% versus 43.8%, p=0.07) and III-IV (0 versus 18.8%, p=0.05%) acute GVHD as compared to high ALC group (32 patients). The results suggested that this low-dose ATG/PTCy regimen was feasible and pre-ATG ALC levels could influence the occurrence of acute GVHD in this regimen.