bluuebunny/crossref_metadata_2025_split huggingface dataset:
Searching for beyond the Standard Model physics using the improved description of 100Mo $$2\nu \beta \beta $$ decay spectral shape with CUPID-Mo
Authors: Augier C. , Barabash A. S. , Bellini F. , Benato G. , Beretta M. , Bergé L. , Billard J. , Borovlev Yu. A. , Cardani L. , Casali N. , Cazes A. , Celi E. , Chapellier M. , Chiesa D. , Dafinei I. , Danevich F. A. , De Jesus M. , Dixon T. , Dumoulin L. , Eitel K. , Ferri F. , Fujikawa B. K. , Gascon J. , Gironi L. , Giuliani A. , Grigorieva V. D. , Gros M. , Helis D. L. , Huang H. Z. , Huang R. , Imbert L. , Juillard A. , Khalife H. , Kleifges M. , Kobychev V. V. , Kolomensky Yu. G. , Konovalov S. I. , Kotila J. , Loaiza P. , Ma L. , Makarov E. P. , de Marcillac P. , Mariam R. , Marini L. , Marnieros S. , Navick X. F. , Nones C. , Norman E. B. , Olivieri E. , Ouellet J. L. , Pagnanini L. , Pattavina L. , Paul B. , Pavan M. , Peng H. , Pessina G. , Pirro S. , Poda D. V. , Polischuk O. G. , Pozzi S. , Previtali E. , Redon Th. , Rojas A. , Rozov S. , Sanglard V. , Scarpaci J. A. , Schmidt B. , Shen Y. , Shlegel V. N. , Šimkovic F. , Singh V. , Tomei C. , Tretyak V. I. , Umatov V. I. , Vagneron L. , Velázquez M. , Ware B. , Welliver B. , Winslow L. , Xue M. , Yakushev E. , Zarytskyy M. , Zolotarova A. S. 
Published: September 2024

AbstractThe current experiments searching for neutrinoless double-$$\beta $$
β
($$0\nu \beta \beta $$

0
ν
β
β

) decay also collect large statistics of Standard Model allowed two-neutrino double-$$\beta $$
β
($$2\nu \beta \beta $$

2
ν
β
β

) decay events. These can be used to search for Beyond Standard Model (BSM) physics via $$2\nu \beta \beta $$

2
ν
β
β

decay spectral distortions. 100Mo has a natural advantage due to its relatively short half-life, allowing higher $$2\nu \beta \beta $$

2
ν
β
β

decay statistics at equal exposures compared to the other isotopes. We demonstrate the potential of the dual read-out bolometric technique exploiting a 100Mo exposure of 1.47 kg $$\times $$
×
years, acquired in the CUPID-Mo experiment at the Modane underground laboratory (France). We set limits on $$0\nu \beta \beta $$

0
ν
β
β

decays with the emission of one or more Majorons, on $$2\nu \beta \beta $$

2
ν
β
β

decay with Lorentz violation, and $$2\nu \beta \beta $$

2
ν
β
β

decay with a sterile neutrino emission. In this analysis, we investigate the systematic uncertainty induced by modeling the $$2\nu \beta \beta $$

2
ν
β
β

decay spectral shape parameterized through an improved model, an effect never considered before. This work motivates searches for BSM processes in the upcoming CUPID experiment, which will collect the largest amount of $$2\nu \beta \beta $$

2
ν
β
β

decay events among the next-generation experiments.
ASSOCIATION OF THE FECAL MICROBIOME WITH IDIOPATHIC SCOLIOSIS IN ADOLESCENTS
Authors: Smirnova Yuliya D. , Burakova Inna Yu. , Gryaznova Mariya V. , Morozova Polina D. , Togidnyy Alexander A. , Kryukova Olga N. , Korneeva Olga S. , Syromyatnikov Mikhail Yu. 
Published: September 2024

Background: Adolescent idiopathic scoliosis is a frequent spinal disorder that manifests itself in varying degrees of severity. However, the etiology of this disease is still unclear. Lately, 16S rRNA sequencing has been increasingly used as a common method to analyze the composition of the faecal microbiota in different diseases. This increased interest has led to investigations into the bacterial composition of people with scoliosis. Methods: We examined the V3 region of the 16S rRNA gene in children diagnosed with adolescent idiopathic scoliosis using NGS sequencing. Results: It was established that in the fecal microbiome of a group of children with scoliosis there is an increase in the number of bacterial genera Erysipelotrichaceae UCG-003, Eubacterium fissicatena, Paeniclostridium, Monoglobus, Blautia and Christensenellaceae R-7, as well as a decrease in the number of genera Dialister, Pseudobutyrivibrio, Prevotella and Escherichia-Shigella. Our study also found a correlation between bacteria and the degree of scoliosis. Conclusion: High abundance of Bilophila, Oscillospira and Paludicola was associated with more severe forms of scoliosis, and the prevalence of Clostridium sensu stricto 1 and Dialister was associated with decreased disease severity. The results of our study may indicate new bacterial markers associated with the development and severity of scoliosis in children.
Lung Cancer Screening Uptake under the Revised United States Preventive Services Task Force Guideline: Assessing Disparities
Authors: Gudina Abdi T. , Kamen Charles S. , Hirko Kelly A. , Adler David H. , Ossip Deborah J. , Williams Edith M. , Cheruvu Vinay K. , Cupertino Ana-Paula 
Published: September 2024

Abstract

Background:
Scanning with low-dose computed tomography reduces lung cancer mortality by 20% among high-risk individuals. Despite its efficacy, the uptake of lung cancer screening (LCS) remains low. Our study aimed to estimate state-level and nationwide LCS rates among eligible individuals and to assess disparities in LCS uptake.

Methods:
Data for this study were obtained from the 2022 Behavioral Risk Factor Surveillance System. Multivariable logistic regression models were used to model the associations between predictors and outcome variables and to examine LCS variability across states.

Results:
Of the 28,071 participants eligible for LCS, 17.24% underwent LCS. Participants ages 65 to 79 years were [OR, 1.75; 95% confidence interval (CI), 1.54–1.99] more likely to undergo LCS than their younger counterparts. Those who were female (OR, 0.83; 95% CI, 0.73–0.94); divorced, separated, or widowed (OR, 0.85; 95% CI, 0.74–0.98); without health insurance (OR, 0.34; 95% CI, 0.22–0.53); without a primary care provider (OR, 0.29; 95% CI, 0.19–0.44); and without chronic obstructive pulmonary disease or those who did not disclose their chronic obstructive pulmonary disease status (OR, 0.35; 95% CI, 0.31–0.40 and OR, 0.37; 95% CI, 0.19–0.73, respectively) were less likely to undergo LCS than their respective counterparts. LCS uptake also varied significantly across U.S. states.

Conclusions:
We observed a low uptake of LCS overall and significant variability in LCS uptake by sociodemographic and health-related factors, as well as by state of residence.

Impact:
The findings from this study have important implications for community health workers and healthcare clinicians and indicate the need to design effective interventions to increase LCS uptake, targeting specific subgroups of populations and particular U.S. states.
See related In the Spotlight, p. 9
Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Authors: Dallos Matthew C. , Obradovic Aleksandar Z. , McCann Patrick , Chowdhury Nivedita , Pratapa Aditya , Aggen David H. , Gaffney Christopher , Autio Karen A. , Virk Renu K. , De Marzo Angelo M. , Antonarakis Emmanuel S. , Scher Howard I. , Drake Charles G. , Rathkopf Dana E. 
Published: September 2024

Abstract

Purpose:
Androgen deprivation therapy (ADT) remains the backbone of prostate cancer treatment. Beyond the suppression of testosterone and tumor cell growth, emerging evidence suggests that ADT also modulates the immune tumor microenvironment. However, a more precise understanding of the timing and intricacies of these immunologic shifts is needed.

Experimental Design:
In this study, we analyzed 49 primary prostate cancers, comparing those surgically removed either without treatment or following treatment with degarelix at 4, 7, and 14 days before surgery. Utilizing next-generation DNA and RNA sequencing and multiplexed immunofluorescence, we examined alterations in immune phenotypes in the presence or absence of ADT.

Results:
Our findings reveal that ADT rapidly transforms the typically bland prostate tumor microenvironment into an inflamed environment within days. Notably, we observed an increase in activated CD8 T cells along with an increase in suppressive regulatory T cells (Treg). We also found an expansion of the myeloid compartment, particularly proinflammatory M1-like tumor-associated macrophages. Intriguingly, discernable changes which have not previously been described also occurred in tumor cells, including upregulation of antigen presentation by MHC classes I and II and, unexpectedly, a decrease in the “do not eat me” signal CD47.

Conclusions:
These observations underscore the critical role of timing and disease context in order to optimize the therapeutic efficacy of immune modulators combined with androgen ablation, for which the presurgical neoadjuvant setting may be ideal. Our findings warrant future prospective validation, which is currently underway.
Hypophosphatemia Correction Reduces ICANS Incidence and Duration in CAR T-cell Therapy: A Pooled Clinical Trial Analysis
Authors: Tang Jack Pengfei , Lafeuille Penelope , Socolov Alexandru , Diamond Sheila S. , Aptekar Jacob , Moore Theodore B. , Nie Esther H. , Hanudel Mark R. , Nowicki Theodore S. 
Published: September 2024

Abstract

A common complication of chimeric antigen receptor (CAR) T-cell therapy is immune effector cell–associated neurotoxicity syndrome (ICANS), which presents with encephalopathy, aphasia, inattention, somnolence, seizures, weakness, or cerebral edema. Despite its significant morbidity, there are currently no effective targeted treatments. Given the clinical similarities between ICANS and the neurological manifestations of acute hypophosphatemia, we retrospectively reviewed 499 patients treated with CD19-targeted CAR T-cell therapy across multiple clinical trials between 2015 and 2020. In addition to clinical toxicities experienced by the patients, we also interrogated the impact of serum electrolyte data and repletion of corresponding electrolyte deficiencies with ICANS incidence, severity, and duration. Hypophosphatemia was a common occurrence in CAR T-cell recipients and the only electrolyte derangement associated with a significantly higher cumulative incidence of ICANS. Moreover, phosphorus repletion in patients with hypophosphatemia was associated with significantly decreased ICANS incidence and duration. Hypophosphatemia was uniquely associated with encephalopathy neurological adverse events, which also showed the strongest positive correlation with both ICANS and cytokine release syndrome severity. These findings suggest that serum phosphorus could be a reliable biomarker for ICANS, and expeditious, goal-directed phosphorus repletion in response to serum hypophosphatemia could be a safe, inexpensive, and widely available intervention for such patients.

Significance:
Herein we show that phosphorus repletion in patients with hypophosphatemia receiving anti-CD19 chimeric antigen receptor T-cell therapeutics was associated with significantly decreased immune effector cell–associated neurotoxicity syndrome (ICANS) incidence and symptom duration. Given the significant morbidity associated with ICANS and lack of targeted interventions, hypophosphatemia may serve as both a useful biomarker and an inexpensive intervention for ICANS.
Variability in Lipid Profiles During Young Adulthood and the Risk of Coronary Artery Calcium Incidence in Midlife: Insights From the CARDIA Study
Authors: Gao Jing-Wei , Hao Qing-Yun , Lin Ying , Li Ze-Hua , Huang Ze-Gui , Bai Zhi-Qiang , Zhang Hai-Feng , Wu Yu-Biao , Xiong Zhuo-Chao , You Si , Wang Jing-Feng , Zhang Shao-Ling , Liu Pin-Ming 
Published: September 2024

BACKGROUND:
Intraindividual variability in lipid profiles is recognized as a potential predictor of cardiovascular events. However, the influence of early adulthood lipid profile variability along with mean lipid levels on future coronary artery calcium (CAC) incidence remains unclear.

METHODS:
A total of 2395 participants (41.6% men; mean±SD age, 40.2±3.6 years) with initial CAC =0 from the CARDIA study (Coronary Artery Risk Development in Young Adults) were included. Serial lipid measurements were obtained to calculate mean levels and variability of total cholesterol, low-density lipoprotein cholesterol (LDL-C), non–high-density lipoprotein cholesterol (non-HDL-C), and triglycerides. CAC incidence was defined as CAC >0 at follow-up.

RESULTS:

During a mean follow-up of 9.0 years, 534 individuals (22.3%) exhibited CAC incidence. Higher mean levels of total cholesterol, LDL-C, and non-HDL-C were associated with a greater risk of future CAC incidence. Similarly, 1-SD increment of lipid variability, as assessed by variability independent of the mean, was associated with an increased risk of CAC incidence (LDL-C: hazard ratio, 1.139 [95% CI, 1.048–1.238];
P
=0.002; non-HDL-C: hazard ratio, 1.102 [95% CI, 1.014–1.198];
P
=0.022; and triglycerides: hazard ratio, 1.480 [95% CI, 1.384–1.582];
P
<0.001). Combination analyses demonstrated that participants with both high lipid levels and high variability in lipid profiles (LDL-C and non-HDL-C) faced the greatest risk of CAC incidence. Specifically, elevated variability of LDL-C was associated with an additional risk of CAC incidence even in low mean levels of LDL-C (hazard ratio, 1.396 [95% CI, 1.106–1.763];
P
=0.005). These findings remained robust across a series of sensitivity and subgroup analyses.

CONCLUSIONS:
Elevated variability in LDL-C and non-HDL-C during young adulthood was associated with an increased risk of CAC incidence in midlife, especially among those with high mean levels of atherogenic lipoproteins. These findings highlight the importance of maintaining consistently low levels of atherogenic lipids throughout early adulthood to reduce subclinical atherosclerosis in midlife.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT00005130.
Age-related Electrophysical Correlates of Cross-modal Attention Switching
Authors: Huang Pi-Chun , Schils Ludivine A. P. , Koch Iring , Stephan Denise N. , Hsieh Shulan 
Published: September 2024

Abstract
The human experience demands seamless attentional switches between sensory modalities. Aging raises questions about how declines in auditory and visual processing affect cross-modal attention switching. This study used a cued cross-modal attention-switching paradigm where visual and auditory stimuli were simultaneously presented on either spatially congruent or incongruent sides. A modality cue indicated the target modality, requiring a spatially left versus right key-press response. EEG recordings were collected during task performance. We investigated whether the mixing costs (decreased performance for repetition trials in a mixed task compared with a single task) and switch costs (decreased performance for a switch of target modality compared with a repetition) in cross-modal attention-switching paradigms would exhibit similarities in terms of behavioral performance and the ERP components to those observed in the traditional unimodal attention-switching paradigms. Specifically, we focused on the ERP components: cue-locked P3 (mixing/switch-related increased positivity), target-locked P3 (mixing/switch-related decreased positivity), and target-locked lateralized readiness potential (mixing/switch-related longer latency). In addition, we assessed how aging impacts cross-modal attention-switching performance. Results revealed that older adults exhibited more pronounced mixing and switch costs than younger adults, especially when visual and auditory stimuli were presented on incongruent sides. ERP findings showed increased cue-locked P3 amplitude, prolonged cue-locked P3 latency, decreased target-locked P3 amplitude, prolonged target-locked P3 latency in association with switch costs, and prolonged onset latency of the target-locked lateralized readiness potential in association with the mixing costs. Age-related effects were significant only for cue-locked P3 amplitude, cue-locked P3 latency (switch-related), and target-locked P3 latency (switch-related). These findings suggest that the larger mixing costs and switch costs in older adults were due to the inefficient use of modality cues to update a representation of the relevant task sets, requiring more processing time for evaluating and categorizing the target.
Jung’s Recalcitrant Fourth
Authors: Cerminara Barbara 
Published: September 2024

Abstract
This paper enlists Jung’s notion of recalcitrant fourth to argue that, contrary to what some Jungian scholars contend, the work of the South African Truth and Reconciliation Commission (TRC) is not illustrative of the transformative process that Jung’s concept of transcendent function aims to illuminate. The TRC created a moral split between redeemed victim and resentful victim, discrediting and marginalising those who refused to reconcile: Winnie Madikizela-Mandela was among them. Where antagonism is not allowed expression, no potential regeneration can take place. The recalcitrant fourth is a disruptor of harmony, and as such feared by the dominant ego position. Nevertheless, Jung cautions not to banish the fourth, as it affords consciousness with a crucial access to the crude realities of existence. Despite her questionable character, Madikizela-Mandela’s resentment should have been taken seriously, as it pointed towards the deeply ingrained social and economic inequalities that still today are cause of resentment among many disillusioned Born Frees.
Cultural Heritage Work in Turkey: a Roundtable
Authors: Açıkyıldız Birgül , Andersen Angela , Büyüksaraç Güldem Baykal , Johnson Peri , Maranci Christina 
Published: September 2024

Abstract
This round table highlights the experiences and perspectives of individuals engaged in projects of cultural preservation in Turkey. Its participants work on, what might be called, the heritage of “minority” cultures – including that of Armenia, but also those of Alevi, Chaldean, Georgian, Greek, Syrian, and other communities that run counter to mainstream political narratives about indigeneity and autochthony. It addresses the challenges of heritage preservation in Turkey, the role of state policy and that of the public, questions of intangible versus tangible heritage, concepts of minority/majority cultures, and reflects on recent successes and failures of conservation in Turkey.
TRACER Perspectives on Gulf-Breeze and Bay-Breeze Circulations and Coastal Convection
Authors: Wang Dié , Melvin Emily C. , Smith Noah , Jensen Michael P. , Gupta Siddhant , Abdullah-Smoot Ayman , Pszeniczny Natalia , Hahn Travis 
Published: September 2024

Abstract
This study explores gulf-breeze circulations (GBCs) and bay-breeze circulations (BBCs) in Houston–Galveston, investigating their characteristics, large-scale weather influences, and impacts on surface properties, boundary layer updrafts, and convective clouds. The results are derived from a combination of datasets, including satellite observations, ground-based measurements, and reanalysis datasets, using machine learning, changepoint detection method, and Lagrangian cell tracking. We find that anticyclonic synoptic patterns during the summer months (June–September) favor GBC/BBC formation and the associated convective cloud development, representing 74% of cases. The main Tracking Aerosol Convection Interactions Experiment (TRACER) site located close to the Galveston Bay is influenced by both GBC and BBC, with nearly half of the cases showing evident BBC features. The site experiences early frontal passages ranging from 1040 to 1630 local time (LT), with 1300 LT being the most frequent. These fronts are stronger than those observed at the ancillary site which is located further inland from the Galveston Bay, including larger changes in surface temperature, moisture, and wind speed. Furthermore, these fronts trigger boundary layer updrafts, likely promoting isolated convective precipitating cores that are short lived (average convective lifetime of 63 min) and slow moving (average propagation speed of 5 m s−1), primarily within 20–40 km from the coast.
Problems and prospects of thermal modernization of farm buildings in rural areas in Poland
Authors: Piwowar Arkadiusz 
Published: September 2024

Abstract
Background
Thermal upgrading is an important element in the economic transformation of Poland towards a low-emission economy. This paper presents the results of research into the current status and plans of inhabitants of rural areas in Poland with regard to thermal upgrading of residential buildings and other buildings used in the agricultural activity of the study participants. The main purpose of the article is to identify thermal modernization needs and to analyse factors influencing individual thermal modernization plans in terms of replacement or modernization of heating systems. A key element of the analyses was the issue of upgrading priorities and the dependency between declared intentions in terms of thermal upgrading work and the production and economic features of the farms studied.

Results
The main research material were surveys conducted with a randomly selected sample of 480 farming households in Poland. The analyses used, amongst others, multiple correspondence analysis (MCA) to determine and assess the relationships between the variables studied. Detailed correspondence analysis shows that there are strong dependencies between plans for thermal upgrading of farm buildings and the system of agricultural production (φ2 = 0.1503), the economic size of farms (φ2 = 0.1100), and the location of farms (φ2 = 0.0947).

Conclusions
The research showed that there is a need for thermal upgrading in the examined area of study, especially with regard to the replacement or modernisation of heating systems. The issue of thermal upgrading of residential and farm buildings in rural areas in Poland requires support and engagement at all levels of administration, as well as the modernisation of assistance programmes.
Differential performance regarding the relationship of C3-epi-25(OH)D3 levels and %C3-epi-25(OH)D3 with common pediatric diseases: a case control study
Authors: Yang Tao , Chen Xiaohong , Wang Miyan , Xu Shaohua , Hu Dong , Tang Jie , Yang Yuwei 
Published: September 2024

Abstract
Background
Recently, the C3-epimer of 25-hydroxyvitamin D [C3-epi-25(OH)D] has become a topic of interest among 25-hydroxyvitamin D [25(OH)D] metabolites. Although it can lead to an overestimation of vitamin D storage, its relationship with disease occurrence remains controversial, possibly related to the great extent of tracking of 25(OH)D by C3-epi-25(OH)D over time. This study aimed to investigate the differential performance of C3-epi-25(OH)D3 and its percentage [%C3-epi-25(OH)D3] with respect to 20 common paediatric diseases.

Methods
This study involved 805 healthy children and adolescents and 2962 patients with common paediatric diseases. We investigated sex, age, and seasonal differences in C3-epi-25(OH)D3 and %C3-epi-25(OH)D3 levels; their variations on 20 common paediatric diseases; and their degree of correlation with 25(OH)D3 levels and various diseases.

Results
Among the healthy underage participants, C3-epi-25(OH)D3 and %C3-epi-25(OH)D3 changed similarly, with no sex differences. Moreover, their levels were higher in the infant period than in the other periods (t = 5.329–5.833, t = 4.640–5.711, all Padj < 0.001), and in spring and summer than in autumn and winter (t = 3.495–6.061, t = 3.495–5.658, all Padj < 0.01). Under healthy and disease conditions, C3-epi-25(OH)D3 was positively correlated with 25(OH)D3 (ρ = 0.318 ~ 0.678, all P < 0.017), whereas %C3-epi-25(OH)D3 was not, except in patients with nephrotic syndrome (ρ=-0.393, P = 0.001). Before and after adjusting for 25(OH)D3, the relationship of C3-epi-25(OH)D3 with the diseases was notably different. However, it was almost consistent for %C3-epi-25(OH)D3. Our results indicated that %C3-epi-25(OH)D3 was associated with short stature, nephrotic syndrome, lymphocytic leukaemia, rickets, paediatric malnutrition, and hypovitaminosis D (OR = 0.80 ~ 1.21, all P < 0.05).

Conclusions
The %C3-epi-25(OH)D3 can correct the properties of C3-epi-25(OH)D3 to better track 25(OH)D3 and may be more suitable for exploring its pathological relevance. Further detailed studies of each disease should be conducted.