bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of prognosis prediction model and visualization system of acute paraquat poisoning based on improved machine learning model
Authors: Li Long , Han Xinxuan , Zhang Zhigang , Han Tingyong , Wu Peng , Xu Yisha , Zhang Liangjie , Liu Zhenyi , Xi Zhenzhong , Li Haoran , Yu Xiangjiang , He Pan , Zhang Ming 
Published: October 2024

Objective This study aims to develop a prognosis prediction model and visualization system for acute paraquat poisoning based on an improved machine learning model. Methods 101 patients with acute paraquat poisoning admitted to 6 hospitals from March 2020 to March 2022 were selected for this study. After expiry of the treatment period (one year of follow-up for survivors and up to the time of death for deceased patients) and they were categorized into the survival group (n = 37) and death group (n = 64). The biochemical indexes of the patients were analyzed, and a prognosis prediction model was constructed using HHO-XGBoost, an improved machine-learning algorithm. Multivariate logistic analysis was used to verify the value of the self-screening features in the model. Results Seven features were selected in the HHO-XGBoost model, including oral dose, serum creatinine, alanine aminotransferase (ALT), white blood cell (WBC) count, neutrophil count, urea nitrogen level, and thrombin time. Univariate analysis showed statistically significant differences between these features’ survival and death groups (P < 0.05). Multivariate logistic analysis identified four features significantly associated with prognosis- serum creatinine level, oral dose, ALT level, and WBC count - indicating their critical significance in predicting outcomes. Conclusion The HHO-XGBoost model based on machine learning is precious in constructing a prognosis prediction model and visualization system for acute paraquat poisoning, which can help clinical prognosis prediction of patients with paraquat poisoning.
Outcomes in patients receiving continuous monitoring of vital signs on general wards: A systematic review and meta-analysis of randomised controlled trials
Authors: Bowles Tim , Trentino Kevin M. , Lloyd Adam , Trentino Laura , Jones Glynis , Murray Kevin , Thompson Aleesha , Halpin Sarah , Waterer Grant 
Published: October 2024

Objective The timely identification of deterioration on general wards is crucial to patient care with each hour of delay independently associated with increased risk of death. The introduction of continuous monitoring of patient vital signs on general wards, currently not standard care, may improve patient outcomes. Our aim was to investigate whether patients on general wards receiving continuous vital signs monitoring have better outcomes than patients receiving usual care. Methods Meta-analysis of randomised controlled trials comparing non-critical care patients receiving continuous monitoring of vital signs to usual care. We searched Medline, Embase, and Web of Science, and assessed risk of bias with version 2 of the Cochrane risk-of-bias tool for randomised trials. In addition to measures related to the early detection of deterioration, we planned to present all patient outcomes reported by the clinical trials included. Results We included seven trials involving 1284 participants. There were no statistically significant differences in the four outcomes pooled. Comparing continuously monitored to normal care, the pooled odds for hospital mortality, major event/complication, and HDU/ICU admission was 0.95 (95% CI 0.59–1.53, p = 0.84; 660 participants, 3 studies), 0.71 (95% CI 0.38–1.31, p = 0.27; 948 participants, 4 studies) and 0.82 (95% CI 0.25–2.67, p = 0.74; 655 participants, 4 studies), respectively. The mean difference for length of stay was 2.12 days lower (95% CI −5.56 to 1.32, p = 0.23; 1034 participants, 6 studies). Conclusion We found no significant improvements in outcomes for patients continuously monitored compared to usual care. Further research is needed to understand what modalities of continuous monitoring may influence outcomes and investigate the implications of a telepresence service and multi-parameter scoring system. Registration PROSPERO CRD42023458656.
Determining the Patient Acceptable Symptom State (PASS) for Shoulder Strength After Subscapularis Arthroscopic Repair and Evaluating the Preoperative Predictors for PASS Achievement
Authors: Gonzalez-Morgado Diego , Ardebol Javier , Kilic Ali Ihsan , Noble Matthew B. , Galasso Lisa A. , Menendez Mariano E. , Denard Patrick J. 
Published: October 2024

Background: Restoring shoulder strength after arthroscopic rotator cuff repair (ARCR) is critical, but there is limited understanding as to what patients consider satisfactory postoperative strength. Purpose: To determine the Patient Acceptable Symptom State (PASS) values for the Constant score strength parameter and internal rotation (IR) strength in patients who underwent ARCR for rotator cuff tears involving the subscapularis (SSC) muscle and evaluate for associations between preoperative and intraoperative patient characteristics with PASS achievement. Study Design: Case-control study; Level of evidence, 3. Methods: A retrospective analysis was conducted on prospectively collected data for 278 patients with an SSC tear (isolated or combined) who underwent ARCR and had minimum 2-year follow-up data. Functional outcomes (patient-reported outcomes, range of motion, Constant strength, and IR strength) were assessed preoperatively and at the latest follow-up. The overall, male, and female PASS values for postoperative strength measures were evaluated using receiver operating characteristic analysis. Correlation and logistic regression analyses were used to evaluate the relationship between preoperative variables and PASS achievement for Constant and IR strengths. Results: The mean follow-up time was 72.8 months. The overall, male, and female PASS values were 9.9 lb (4.5 kg), 14.5 lb (6.6 kg), and 8.5 lb (3.9 kg), respectively, for Constant strength and 15.2 lb (6.9 kg), 20.7 lb (9.4 kg), and 12.1 lb (5.5 kg), respectively, for IR strength. Older age, high fatty infiltration of the SSC tendon (Goutallier grades 3 and 4), and failure of SSC healing correlated negatively with PASS attainment for the strength measures. High fatty infiltration of the supraspinatus and infraspinatus muscles correlated negatively with Constant strength. Decreased coracohumeral distance (CHD) and larger SSC tears correlated negatively with achieving PASS for IR strength. Workers’ compensation, high supraspinatus and SSC fatty infiltration, and the use of knotted suture anchors were predictors of not achieving the overall Constant strength PASS, while lower SSC fatty infiltration and high CHD were predictors of achieving the overall IR strength PASS. Conclusion: This study established the PASS values for Constant and IR strengths for patients after ARCR involving the SSC tendon. Workers’ compensation, high supraspinatus and SSC fatty infiltration, and the use of knotted suture anchors were predictors of not achieving the overall Constant strength PASS, while lower SSC fatty infiltration and high CHD were predictors of achieving the overall IR strength PASS.
A novel mutation in the ATP1A2 gene associated with a sporadic hemiplegic migraine and multiple supraventricular arrhythmias: A case report
Authors: Shalchian Tehran Sarvnaz , Maquet Pierre 
Published: October 2024

Introduction ATP1A2 mutations are identified as a genetic cause of type 2 hemiplegic migraine, but to date, no ATP1A2 gene variant has been linked to heart rhythm disorders Case presentation A 37-year-old woman presented with sporadic hemiplegic migraine and multiple supraventricular arrhythmias refractory to medical treatment and electrophysiological interventions. Genetic workup revealed a mutation in the ATP1A2 gene (c.1827 + 10delT) which was not previously described. The co-segregation study supported the causal participation of the variant since it was found in the migrainous sister but not in the non-migrainous father. Conclusions We suggest that the c.1827 + 10delT mutation in the ATP1A2 gene is a novel pathogenic mutation linked to both hemiplegic migraine and supraventricular arrhythmias.
Sex Education Training as Capacity Building Tool for Mothers and their Children with Intellectual Disability: A Qualitative Study
Authors: Gupta Babita 
Published: October 2024

Sex is a biological need of human beings and the aspects of sexuality and sexual development are less discussed in people with intellectual disability (ID). Sex education training (SET) for persons with ID and their parents is pivotal in mitigating challenges and creating a safe and healthy space for expressing their sexual needs. The aim was (a) to see the effects of SET in the enhancement of knowledge and skills about sexual health among adults with ID, (b) To see the effect of mothers as an observer during SET on their perception, attitude and practice on sexual health for their children with ID. The sample consisted of 11 mothers and their children who were above 18 years with ID. Awareness of sexual health education for parents of intellectually challenged children and family life and sexual health assessment tools were used. A qualitative/descriptive analysis was done. SET was started for the period of three months, two sessions in a week, each session lasting one and half hours. It was done in a playful manner on self and social awareness, safe/unsafe touch, relationships, personal safety rules and sexual harassment of women at workplace (POSH). SET shows not only enhancement in the level of awareness, knowledge on sexual health but also improved communication skills and decision-making skills among adults with ID and their mothers. Mothers feel more confident and comfortable to have open discussions with their children on sexual health.
Assessment of Sexual Dysfunction in Male Patients with Young-Onset Parkinson’s Disease: A Case-Control Study
Authors: Paneyala Shasthara , Chalasani Sri Harsha , Syed Jehath , Sundaramurthy Harsha , Chandrasekhar Nemichandra Siddanakatte 
Published: October 2024

Introduction: There is a need for a comprehensive assessment of sexual dysfunction in patients with young-onset Parkinson’s disease (PD) to better understand its impact on this population. This study aimed to assess sexual dysfunction in patients with young-onset PD. Methods: This case-control study was conducted using a self-administered International Index of Erectile Function Scale (IIEF) questionnaire. The questionnaire included questions related to sexual function, including the ability to achieve and maintain erection and sexual desire. The participants included 30 individuals with young-onset PD and 30 controls without PD who were matched for age and gender. Results: The study enrolled 30 patients with an average age of 37.2 ± 5.29 years and PD symptom duration ranging from less than two years to over two years. Most patients were classified as having stage 2 or 3 PD and exhibited a range of symptoms, such as bradykinesia, tremors, rigidity, and postural instability. The findings revealed that 40% of the PD group experienced moderate erectile dysfunction, while 23.33% reported severe dysfunction, in contrast to the absence of dysfunction observed in the control group. The analysis indicated that patients with a disease duration of less than two years had higher scores across all five components of the IIEF questionnaire. Furthermore, anxiety, depression, increased medication use, and disease severity significantly affected sexual function. Conclusion: This study highlights the impact of young-onset PD on sexual function and underscores the importance of the early recognition and management of sexual dysfunction in patients with PD.
Custom Glenoid Baseplate to Address Massive Glenoid Bone Loss in Reverse Total Shoulder Arthroplasty
Authors: Moran Thomas E. , Ramamurti Pradip , Nauert Richard , Werner Brian C. , Brockmeier Stephen F. 
Published: October 2024

Background: A patient-specific, 3-dimensional-printed, custom glenoid baseplate can be utilized to address severe glenoid deficiency in reverse total shoulder arthroplasty (rTSA). Indications: A 73-year-old woman with right shoulder pain, weakness, and decreased range of motion in the setting of glenohumeral arthritis with severe glenoid bone loss. Additionally, this implant system was used in a 77-year-old man undergoing conversion to rTSA in the setting of glenoid erosion following prior failed total shoulder arthroplasty. Technique Description: A standard deltopectoral approach is utilized. In the revision setting, prior components are removed. Adequate glenoid exposure is obtained to allow for positioning and implantation of the custom glenoid baseplate. The glenoid is prepared utilizing patient-specific guides and trials before the custom glenoid component is seated within the glenoid vault and fixated with locking screws. Compatible glenosphere and humeral components are utilized for the remainder of the surgical procedure, as performed standardly. Results: There were no immediate complications following surgery. Surgical management led to improvement in the patient's pain and shoulder function. Discussion/Conclusion: Patient-specific, 3-dimensional-printed, custom glenoid baseplates may be used to manage severe glenoid deformity and bone loss in patients indicated for primary or revision rTSA. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
TR4 and BCL11A repress γ-globin transcription via independent mechanisms
Authors: Wang Yu , Myers Greggory , Yu Lei , Deng Kaiwen , Balbin-Cuesta Ginette , Singh Sharon A. , Guan Yuanfang , Khoriaty Rami , Engel James Douglas 
Published: October 2024

Abstract
Nuclear receptor TR4 (NR2C2) was previously shown to bind to the –117 position of the γ-globin gene promoters in vitro, which overlaps the more recently described BCL11 transcription factor A (BCL11A) binding site. The role of TR4 in human γ-globin gene repression has not been extensively characterized in vivo, whereas any relationship between TR4 and BCL11A regulation through the γ-globin promoters is unclear at present. We show here that TR4 and BCL11A competitively bind in vitro to distinct, overlapping sequences, including positions overlapping –117 of the γ-globin promoter. We found that TR4 represses γ-globin transcription and fetal hemoglobin accumulation in vivo in a BCL11A-independent manner. Finally, examination of the chromatin occupancy of TR4 within the β-globin locus, compared with BCL11A, shows that both bind avidly to the locus control region and other sites, but only BCL11A binds to the γ-globin promoters at statistically significant frequency. These data resolve an important discrepancy in the literature and, thus, clarify possible approaches to the treatment of sickle cell disease and β-thalassaemia.
T-cell lymphomas in recipients of CAR-T cells: assessing risks and causalities
Authors: Hu Jingqiong , Dunbar Cynthia E. 
Published: October 2024

Abstract
The US Food and Drug Administration announcement in November 2023 regarding reports of the occurrence of secondary T-cell lymphomas in patients receiving chimeric antigen receptor T cells (CAR-Ts) for B-cell malignancies resulted in widespread concern among patients, clinicians, and scientists. Little information relevant to assessing causality, most importantly whether CAR retroviral or lentiviral vector genomic insertions contribute to oncogenesis, was initially available. However, since that time, several publications have provided clinical and molecular details on 3 cases showing clonal CAR vector insertions in tumor cells but without firm evidence these insertions played any role in oncogenic transformation. In addition, several other cases have been reported without vector detected in tumor cells. In addition, epidemiologic analyses as well as institutional long-term CAR-T recipient cohort studies provide important additional information suggesting the risk of T-cell lymphomas after CAR-T therapies is extremely low. This review will provide a summary of information available to date, as well as review relevant prior research suggesting a low susceptibility of mature T cells to insertional oncogenesis and documenting the almost complete lack of T-cell transformation after natural HIV infection. Alternative factors that may predispose patients treated with CAR-Ts to secondary hematologic malignancies, including immune dysfunction and clonal hematopoiesis, are discussed, and likely play a greater role than insertional mutagenesis in secondary malignancies after CAR therapies.
Outcome of patients with large B-cell lymphoma treated with tafasitamab plus lenalidomide either before or after CAR T-cell therapy
Authors: Camus Vincent , Houot Roch , Brisou Gabriel , Tessoulin Benoit , Bailly Sébastien , Sesques Pierre , Decroocq Justine , Krzisch Daphné , Oberic Lucie , Lemonnier François , Bouabdallah Krimo , Campidelli Arnaud , Tounes Ledraa , Abraham Julie , Herbaux Charles , Morschhauser Franck , Damaj Gandhi Laurent , Guidez Stéphanie , Carras Sylvain , Fornecker Luc-Matthieu , Choquet Sylvain , Hermine Olivier , Paillassa Jérome , Chauchet Adrien , Casasnovas Olivier , Drieu La Rochelle Laurianne , Castilla-Llorente Cristina , Joris Magalie , Dupont Vivien , Marquet Alexandra , Le Gouill Steven , Jardin Fabrice 
Published: October 2024

Abstract
Tafasitamab plus lenalidomide (TAFA-LEN) treatment relevance pre- or post-anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is debated. We analyzed patients with large B-cell lymphoma in the DESCAR-T registry treated with axi[1]cel or tisa-cel in ≥3rd line and TAFA-LEN before (n = 15, “TL-pre-CAR-T” set) or directly after (n = 52, “TL-post-CAR-T” set) CAR T-cell therapy. We compared TAFA-LEN v. other treatments using inverse probability weighting in the TL-post-CAR[1]T set. In the TL-post-CAR-T set, the median progression-free survival (mPFS), overall survival (mOS), and duration of response (mDOR) since the first treatment for progression (mPFS2/mOS2/mDOR2) were 3, 4.7, and 8.1 months, respectively. The best overall response rate (bORR) and best complete response rate (bCRR) after TAFA-LEN were 13.5% and 7.7%, respectively. Outcomes were better for patients who relapsed &gt;6 months after CAR T-cell therapy (mPFS2: 5.6 vs 2 months, P = .0138; mOS2: not reached vs 3.8 months, P = .0034). The bORR and bCRR between TAFA-LEN and other treatments were 20.6% vs 24.9% and 11.6% vs 15.6%, respectively. Outcomes were similar between TAFA-LEN and other treatments (mPFS2: 2.9 vs 2.4 months, P = .91; mOS2: 3.3 vs 5.5 months, P = .06). In an exploratory analysis of the TL-pre-CAR-T set, the median TAFA-LEN treatment duration before CAR-T was 3.7 months with no patient becoming CD19 negative. The bORR, bCRR, 6- month PFS, and OS rates after CAR T-cell infusion were 45.5%, 36.4%, 20.1%, and 58.2%, respectively. Neither TAFA-LEN nor comparative salvage treatment improved outcomes for patients relapsing after CAR T-cell therapy.
Assessing the impact of different types of masks on COPD patients: A randomized controlled trial
Authors: Fan Jingchun , Feng Tiantian , Jiang Xiaomei , Wei Caihong , Zhang Xuhui , Li Caiyun , Yue Feiyan , Yang Hong , Bao Shisan , Chen Xuwen 
Published: October 2024

BackgroundWearing masks imposes an additional respiratory burden on COPD patients. This study aimed to investigate the impact of various mask types on physiological parameters and subjective feelings in COPD patients.MethodsThis randomized, open-label, parallel-controlled trial randomly assigned 129 COPD patients from 2 Chinese hospitals to the N95 mask group, the surgical mask group and the no mask group, who were required to complete a 6-minute rest (6MR) and a 6-minute walking test (6MWT) while wearing their designated masks, and were assessed for blood pressure, oxygen saturation, pulse rate, Borg score, RPE score, 6-minute walk distance (6MWD), and subjective feeling score. Data were analyzed using intention-to-treat analysis and per-protocol analysis.ResultsNo significant differences were observed in blood pressures, oxygen saturation, pulse rate, or the 6MWD among the three groups following a 6MR or 6MWT. Wearing N95 masks and surgical masks during the 6MWT significantly elevated perceived dyspnea (p<0.001) and exertion scores (p<0.001) in COPD patients. The differences in the 2 scores between the highest and lowest groups were 2 and 4 points, respectively.ConclusionWearing surgical masks or N95 masks for 6MR or 6MWT did not adversely affect physiological parameters in COPD patients. However, it significantly increased perceived dyspnea and exertion.
Differential expression of components of the CGRP-receptor family in human coronary and human middle meningeal arteries: functional implications
Authors: de Vries Tessa , Schutter Dennis , van den Bogaerdt Antoon , Vincent Arnaud , Dammers Ruben , Danser A. H. Jan , MaassenVanDenBrink Antoinette 
Published: October 2024

Abstract
Background
Different responses in human coronary arteries (HCA) and human middle meningeal arteries (HMMA) were observed for some of the novel CGRP receptor antagonists, the gepants, for inhibiting CGRP-induced relaxation. These differences could be explained by the presence of different receptor populations in the two vascular beds. Here, we aim to elucidate which receptors are involved in the relaxation to calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and adrenomedullin 2 (AM2) in HCA and HMMA.

Methods
RNA was isolated from homogenized human arteries (23 HCAs; 12 F, 11 M, age 50 ± 3 years and 26 HMMAs; 14 F, 12 M, age 51 ± 3 years) and qPCR was performed for different receptor subunits. Additionally, relaxation responses to CGRP, AM or AM2 of the human arteries were quantified using a Mulvany myograph system, in the presence or absence of the adrenomedullin 1 receptor antagonist AM22-52 and/or olcegepant.

Results
Calcitonin-like receptor (CLR) mRNA was expressed equally in both vascular beds, while calcitonin receptor (CTR) and receptor activity-modifying protein 3 (RAMP3) expression was low and could not be detected in all samples. RAMP1 expression was similar in HCA and HMMA, while RAMP2 expression was higher in HMMA. Moreover, receptor component protein (RCP) expression was higher in HMMA than in HCA. Functional experiments showed that olcegepant inhibits relaxation to all three agonists in both vascular beds. In HCA, antagonist AM22-52 did not inhibit relaxation to any of the agonists, while a trend for blocking relaxation to AM and AM2 could be observed in HMMA.

Conclusion
Based on the combined results from receptor subunit mRNA expression and the functional responses in both vascular tissues, relaxation of HCA is mainly mediated via the canonical CGRP receptor (CLR-RAMP1), while relaxation of HMMA can be mediated via both the canonical CGRP receptor and the adrenomedullin 1 receptor (CLR-RAMP2). Future research should investigate whether RAMP2 predominance over RAMP1 in the meningeal vasculature results in altered migraine susceptibility or in a different response to anti-migraine medication in these patients. Moreover, the exact role of RCP in CGRP receptor signalling should be elucidated in future research.