bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of vaccination against Japanese encephalitis in endemic countries
Authors: Letson G. William , Marfin Anthony A. , Mooney Jessica , Minh Huong Vu , Hills Susan L. ,   the JE Vaccine Global Impact Assessment Team
Published: September 2024

Background
Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis and a significant cause of disability in Asia and the western Pacific. Many countries have introduced JE vaccination programs, including several low resource countries following WHO’s prioritization of JE vaccination in 2006. We sought to characterize the public health impact of JE vaccination programs.

Methodology/Principal findings
JE case data and vaccination coverage rates, were requested from country health officials in 23 JE endemic countries and Chinese Taipei. Additional data were extracted from meeting presentations and published literature. JE incidence was compared before and after vaccination using a minimum three year period pre and post program introduction or expansion. Data suitable for analysis were available for 13 JE-endemic countries and Chinese Taipei, for either all age groups or for children aged under 15 years only. Five countries and Chinese Taipei introduced vaccine prior to 2006 and the all-age JE incidence was reduced by 73–100% in about 5–20 years following introduction. Six countries have introduced JE vaccine since 2006, and JE incidence in children aged younger than 15 years has been reduced by 14–79% as of 2015–2021. JE-specific data were unavailable before introduction in Thailand and Vietnam, but vaccination programs reduced acute encephalitis incidence by 80% and 74%, respectively. Even in the programs with greatest impact, it took several years to achieve their results.

Conclusions/Significance
JE vaccination has greatly reduced JE in 13 JE-endemic countries and Chinese Taipei. Highest impact has been observed in countries that introduced prior to 2006, but it often took roughly two decades and substantial resources to achieve that level of success. For greatest possible impact, more recently introducing countries and funding agencies should commit to continuous improvements in delivery systems to sustain coverage after initial vaccine introduction.
Therapeutic interventions for heart failure in Colombia: result of a Delphi panel
Authors: Pérez Molina Clímaco de Jesús , Castañeda Orjuela Carlos , Valbuena Hernandez Pedro , Pérez Arias Rafael Ignacio , Pérez Arias María Alejandra , Arias Copete Ana María 
Published: September 2024

Objective
The objective of this study was to validate the main therapies used in the treatment of heart failure through a clinical consensus conducted by cardiology experts in Colombia.

Methods
The Delphi technique was employed, which involves a series of consultation rounds with experts to reach a consensus. Cardiologists with experience in HF treatment were selected, and they were sent electronic questionnaires to assess the relevance of various therapeutic interventions. Consensus was defined when at least 70% of the experts agreed on the relevance of an intervention.

Results
Fourteen cardiology experts participated in the study. In the first round, nine therapeutic interventions were evaluated, but insufficient agreement was reached to form a consensus. A second round was conducted, where feedback was provided to the experts, and they were asked to rate the relevance of the interventions using a Likert scale. Consensus was achieved for eight of the evaluated therapeutic interventions. The focus of the third round was on the interventions that had not reached consensus in the previous rounds.

Conclusions
This study provides clinical consensus on therapeutic interventions for HF in Colombia. Nine therapeutic interventions were identified as relevant by the experts. These findings can help improve HF treatment and optimize clinical outcomes in Colombia. It is important to note that this study was conducted with local experts, and the results may not be generalizable to other populations.
Unleashing the role of e-word of mouth on purchase intention in select Facebook fan pages of smart phone users
Authors: Khan Mohammed Arshad , Minhaj Syed Mohd , Vivek  , Alhashem Mohammed , Nabi Mohammed Kamallun , Saifi Mohd. Afzal , Inkesar Asra 
Published: September 2024

Objective
This study aims to examine the impact of e-WOM on customer purchase intentions in Facebook fan pages using theories of trust, value co-creation and brand attitude. The present research has set out to explore this emerging domain of study and has thus developed & tested propositions which attempt to establish a relationship between e-WOM and customer‘s purchase intentions. A deeper understanding of this possible association is obtained by studying the mediating roles of Trust, Value Co-Creation, Brand Image and Brand Attitude.

Methodology
The context for exploring this phenomenon is chosen to be the fan pages of smartphone brands on Facebook. The study involved conducting a sample survey of 490 respondents, comprising of both male and female, who belong to 5 smartphone brands Facebook fan pages–Samsung, Moto G, Lenovo, MI and ASUS are considered for the study. Out of which sample of 100 each has been targeted individually

Findings
The findings suggested that e-WOM significantly predicts the purchase intentions of the customers of a specific product and considerable impacted on the purchase decision. The findings of the study also reveal that customer ‘s trust beliefs, perceived value co-creation, brand image and brand attitude partially mediate in between relationships of e-WOM and purchase intention

Conclusion
The actual presence of different types of consumer electronics brands on the social media, more prominently, the smartphones, which undoubtedly are the most ubiquitous product of this segment. In fact, this indicates that presence on social media is a well- thought organizational strategy developed by companies to gain partial control over the customer ‘s decision- making process by establishing a close connect with the customers for a long period.

Implication
This consequence will significantly impact the decision-making process of marketers or practitioners in relation to their marketing tactics. This research also indicates that marketers could devise more effective methods for distributing marketing content through social networking sites, while corporations can cultivate favorable electronic word-of-mouth for their products or services. Through the implementation of social media marketing strategies, companies can increase their sales volume and generate higher revenue. The study examined the role of trust, virtual community participation, and desire to purchase as mediators on smartphone brand fan sites on Facebook. It was observed that these factors had a partial influence on customer purchase intention.
Alpha-boswellic acid accelerates acute wound healing via NF-κB signaling pathway
Authors: Dong Fang , Zheng Lijuan , Zhang Xuanfen 
Published: September 2024

Background
Boswellic acids (BAs) showed promising effects in cancer treatment, immune response regulation, and anti-inflammatory therapy. We aimed to assess the roles of alpha-BA (α-BA) in treating acute wound healing.

Methods
In vivo wound-healing models were established to evaluate the therapeutic effects of α-BA. Cell assays were conducted to assess the impact of α-BA on cellular biological functions. Western blot analysis was employed to validate the potential mechanisms of action of α-BA.

Results
Animal models indicated that wound healing was notably accelerated in the α-BA group compared to the control group (P < 0.01). Hematoxylin and eosin (HE) staining and enzyme-linked immunosorbent assay (ELISA) assay preliminarily suggested that α-BA may accelerate wound healing by inhibiting excessive inflammatory reactions and increasing the protein levels of growth factors. Cell function experiments demonstrated that α-BA suppressed the proliferation and migration ability of human hypertrophic scar fibroblasts (HSFBs), thereby favoring wound healing. Additionally, α-BA exerted a significant impact on cell cycle progression. Mechanistically, the protein levels of key genes in nuclear factor kappa beta (NF-κB) signaling pathway, including cyclin D1, p65, IκBα, and p-IκBα, were downregulated by α-BA.

Conclusions
α-BA demonstrated the ability to counteract the abnormal proliferation of skin scar tissues, consequently expediting wound healing. These findings suggest its potential for development as a new agent for treating acute wound healing.
Investigating the association between household exposure to Anopheles stephensi and malaria in Sudan and Ethiopia: A case-control study protocol
Authors: Ashine Temesgen , Ebstie Yehenew Asmamaw , Ibrahim Rayyan , Epstein Adrienne , Bradley John , Nouredayem Mujahid , Michael Mikiyas G. , Sidiahmed Amani , Negash Nigatu , Kochora Abena , Sulieman Jihad Eltaher , Reynolds Alison M. , Alemayehu Eba , Zemene Endalew , Eyasu Adane , Dagne Alemayehu , Hailemeskel Elifaged , Jaiteh Fatou , Geleta Dereje , Lejore Ephrem , Weetman David , Hussien Ahmed Mahmoud , Saad Fadwa , Assefa Gudissa , Solomon Hiwot , Bashir Abdelgadir , Massebo Fekadu , Peeters Koen , Yewhalaw Delenasaw , Kafy Hmooda Toto , Donnelly Martin J. , Gadisa Endalamaw , Malik Elfatih M. , Wilson Anne L. 
Published: September 2024

Background
Endemic African malaria vectors are poorly adapted to typical urban ecologies. However, Anopheles stephensi, an urban malaria vector formerly confined to South Asia and the Persian Gulf, was recently detected in Africa and may change the epidemiology of malaria across the continent. Little is known about the public health implications of An. stephensi in Africa. This study is designed to assess the relative importance of household exposure to An. stephensi and endemic malaria vectors for malaria risk in urban Sudan and Ethiopia.

Methods
Case-control studies will be conducted in 3 urban settings (2 in Sudan, 1 in Ethiopia) to assess the association between presence of An. stephensi in and around households and malaria. Cases, defined as individuals positive for Plasmodium falciparum and/or P. vivax by microscopy/rapid diagnostic test (RDT), and controls, defined as age-matched individuals negative for P. falciparum and/or P. vivax by microscopy/RDT, will be recruited from public health facilities. Both household surveys and entomological surveillance for adult and immature mosquitoes will be conducted at participant homes within 48 hours of enrolment. Adult and immature mosquitoes will be identified by polymerase chain reaction (PCR). Conditional logistic regression will be used to estimate the association between presence of An. stephensi and malaria status, adjusted for co-occurrence of other malaria vectors and participant gender.

Conclusions
Findings from this study will provide evidence of the relative importance of An. stephensi for malaria burden in urban African settings, shedding light on the need for future intervention planning and policy development.
The role of mental health in the relationship between nursing care satisfaction with nurse-patient relational care in Chinese emergency department nursing
Authors: Huang Hui , Cui Jing , Zhang Hua , Gu Yuhui , Ni Haosheng , Meng Ya 
Published: September 2024

Background
The relationship between a nurse and a patient is a key part of nursing that can impact how happy the patient is with the care they receive. It appears that the nurse’s mental health can also affect this connection. However, there is little research on this topic. So, the aim of the present study was to determine the correlation of nurse’s mental health with nurse–patient relational care and nursing care satisfaction.

Methods
A total of 532 nurses and 532 patients from 13 Level-III hospitals of Hubei province (China) completed a China Mental Health Survey, general information questionnaire, the Nursing Care Satisfaction Scale, and Relational Care Scale.

Results
Age, nurse working years, and night shift last month were correlated with mental health score (r = -0.142, r = -0.150, r = 0.164, p < 0.05). Nurse’s mental health was correlated with relational care score and nursing care satisfaction score (r = -0.177, r = -0.325, p < 0.05). Also, relational care score, patients age and gender were correlated with nursing care satisfaction score (r = 0.584 and r = 0.143, x2 = 11.636, p < 0.05). Descriptive information of nurses had a direct impact on nurses’ mental health (direct effect = 0.612, 0.419–0.713). Nurses’ mental health had a direct effect on relational care score (direct effect = 0.493, 0.298–0.428) and an indirect effect on nursing care satisfaction score (indirect effect = 0.051, 0.032–0.074). Relational care score and patient’s descriptive information had also a direct effect on nursing care satisfaction score (direct effect = 0.232, 0.057–0.172 and 0.057, 0.347–0.493).

Conclusion
This study showed that the better the mental health of nurses, the more patients feel satisfied with nursing services.
Simulation of Groundwater Potential Zone Using Geographic Information System (GIS) Through Related Factors
Authors: Olusami Joel Olusoji , Familusi Ayokunle Oluwaseun , Olatunji Abass Adekunle , Ogundare Damilola Ayodele , Akindele Akinsanya Ebenezer , Akinyele Isikilu Oyewole 
Published: September 2024

Groundwater is the primary water source for irrigating and drinking in dry seasons. This work was examined to assess groundwater potential area underlain by basement complex with GIS based approach of selected locations in Osogbo. The soil samples were taken and soil textural and permeability analyses were done in the laboratory. Supervised classification analysis was done on LandSAT imagery to generate Land use and a lineament map, surface analyst algorithm was applied on ASTER dam to generate elevation map. Hydraulic conductivity and overburden thickness maps were generated from the Borehole data parameters. Interpolation method was used to generate spatially spread clay, silt, sand, rainfall and hydraulic conductivity. Multi-criteria analysis was used to generate groundwater potential zone map in the study area. Specific factors were considered for groundwater potential zone. Reclassification was done on each of the considered factors and AHP model was used to assign weight to all the factors. The results of the various factors responsible for groundwater potential include lineament density 0-0.0028; sand 67.2-89.60%, silt 9.00-30.00%, clay 0.17-2.80%, permeability 0.000010-0.00002, rainfall 1304.02-1469.06mm/yr, hydraulic conductivity 0.21-0.96m/min, land use consisting of degraded forest 48.65%, riparian forest 13.05%, built up 38.29%, and water body 0.001%. However, ground water potential of the study area was assessed and classified into fair, good and very good with the coverage of 2%, 80% and 18% respectively. Conclusively, the groundwater recharge potential is very good at Ofatedo, Gbonmi and Oke-Oro locations, good at Awosuru, Gbodofon and Dagbolu locations, but fair at Mallam Tope location in Osogbo
Trojan Nobodies: Uncarnal Knowledge in Troilus and Criseyde
Authors: Arner Timothy D. 
Published: September 2024

Abstract
This article considers the distinct lack of bodies and embodiment throughout Chaucer’s Troilus and Criseyde. While it seems to be a war-time erotic romance in which the plot hinges on the physical threats and pleasures available to its characters, through its many contradictions and deceptions, the poem makes the bodies of Troilus, Criseyde, and Pandarus unknowable, even at their most crucial moments. It is through the frustration of bodily hermeneutics in Troilus and Criseyde that Chaucer signals his rejection of the romance genre and the beginning of an anti-Boethian turn that becomes the governing theme of the first fragment of the Canterbury Tales.
Getting in Touch with Troy in Fifteenth-Century France: The First Prose Version of the Roman de Troie in the Manuscript F°26 of the Abbey of Maredsous
Authors: Rochebouet Anne 
Published: September 2024

Abstract
This paper considers how the codex as a medium, specifically via its illustration and layout, translates into material forms the literary and textual choices of the texts it transmits in order to make its version of the Troy story tangible, and thus intelligible for its medieval readers. It takes as an example the first prose version of the Roman de Troie of Benoît de Sainte-Maure, probably composed in the last quarter of the thirteenthcentury in Frankish Greece, and focuses more specifically on a late manuscript of Prose 1, recently rediscovered, the manuscript F°26 from the Abbey of Maredsous (Belgium), made almost two centuries later, c. 1450, in the Burgundian Netherlands. This paper argues that this codex, in its specific context of production and within its textual and visual traditions, allow its audience to come into contact with the long-lost city of Troy, and the narrative that evokes it.
The role of Cardiotrophin-1 and echocardiography in early detection of subclinical diabetic cardiomyopathy in children and adolescents with type 1 diabetes mellitus
Authors: Hassanein Samah A. , Hassan Mona M. , Samir Mohamed , Aboudeif Mahmoud O. , Thabet Mohamed S. , Abdullatif Mona , Khedr Dina 
Published: September 2024

Abstract

Objectives
To assess the role of Cardiotrophin-1 (CT-1) and echocardiography in early detection of subclinical Diabetic Cardiomyopathy (DCM) in children with type 1 Diabetes Mellitus (T1D).

Methods
This case-control study included two groups of children and adolescents aged between 7 and 18. Group (1) included forty patients with T1D (duration > 5 years) regularly followed at the children's hospital of Cairo University, and Group (2) included forty age and sex-matched healthy subjects as a control group. The serum level of CT-1 was measured, and conventional echocardiography, tissue Doppler imaging (TDI), and 2D speckle tracking echocardiography were performed.

Results
The level of CT-1 in the cases ranged from 11 to 1039.4 pg/ml with a median (IQR) of 19.4 (16.60–25.7) pg/ml, while its level in the control group ranged from 10.8 to 162.6 pg/ml with a median (IQR) of 20.2 (16.2–24.8) pg/ml. CT-1 levels showed no statistically significant difference between cases and controls. Patients had significantly higher mean left ventricle E/E′ ratio (p<0.001), lower mean 2D global longitudinal strain (GLS) of the left ventricle (LV) (p<0.001), and lower mean GLS of the right ventricle (RV) (p<0.001) compared to controls. Ofpatients with diabetes, 75 % had LV diastolic dysfunction, 85 % had RV diastolic dysfunction, 97.5 % had LV systolic dysfunction, and 100 % had RV systolic dysfunction.

Conclusions
Non-conventional echocardiography is important for early perception of subclinical DCM in patients with T1D. Cardiotrophin-1 was not specific for early detection of DCM.
ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
Authors: Lam Ieng-Hou , Chan Chon-In , Han Meixia , Li Lixuan , Yu Hon-Ho 
Published: September 2024

Abstract

Background
The pathogenesis of inflammatory bowel disease (IBD) is closely associated with the dysfunction of the intestinal epithelial barrier, leading to increased bacterial translocation, leukocyte infiltration, and mucosal injury, which may act as a pivotal or incipient event in the pathophysiology of the disorder. The primary objective of this study is to examine the key genes implicated in IBD and the perturbation of intestinal epithelial cell function.

Methods
The genes associated with ferroptosis were identified through the utilization of the Gene Expression Omnibus (GEO) database and the GeneCard database. Additionally, an in vitro model of IBD was established by stimulating Caco-2 cells with lipopolysaccharides (LPSs) to investigate the molecular mechanisms underlying intestinal epithelial cell dysfunction.

Results
We discovered evidence that establishes a connection between ferroptosis and the inflammatory responses associated with the development of IBD. This evidence suggests that IBD patients who exhibit an inflammatory response have higher expression of the acyl-CoA synthetase long-chain family member 4 (ACSL4) gene compared to IBD patients without an inflammatory response or healthy individuals. Exposure to LPS at concentrations of 1 or 10 μg/mL resulted in a significant upregulation of ferroptosis-related genes ACSL4, GPX4, and SLC7A11, as well as an increase in ferroptosis biomarkers MDA and a decrease in CAT and GSH-Px levels compared to the control group. Inhibition of ACSL4 using si-ACSL4 or rosiglitazone demonstrated protective effects against LPS-induced ferroptosis and NF-κB-mediated inflammatory response.

Conclusion
ACSL4 shows potential as a promising target for ferroptosis in the prevention and treatment of IBD and dysfunction of intestinal epithelial cells.
Optimierung von Subsumtionsprozessen
Authors: Krebs Moritz 
Published: September 2024

Abstract
Sowohl Formen der Optimierung als auch der Entgrenzung lassen sich mit Hilfe Marx’scher Begriffe fassen. In diesem Artikel wird skizziert, welche Bedeutung einer gleichermaßen gesellschaftstheoretischen und anthropologischen Verortung dieser kaum zu übersehenden Tendenzen im Zusammenhang mit den veränderten Weltbeziehungen im Kapitalozän zukommt.
Devising a methodology for prototyping convex-concave parts using reverse-engineering technology providing the predefined geometric accuracy of their manufacturing
Authors: Maiorova Kateryna , Kapinus Oleksandra , Nikichanov Viacheslav , Skyba Oleksandr , Suslov Artem 
Published: September 2024

The object of this paper is the geometric accuracy of the acquired portrait from the 3D printed full-scale sample in the reduced size of the convex-concave parts compared to the correspondingly reduced ideal one.
The subject of research is reverse engineering and additive technology for manufacturing convex-concave parts for mechanical engineering (ME). A new prototyping methodology for convex-concave parts of mechanical engineering objects has proposed. Underlying the methodology is the use of the scaled (by reducing in size) ideal portrait of the 3D scanned original part. The decision to start the production is made by comparing the geometry of the portrait acquired from the 3D printed sample in reduced size with the ideal one, provided that the values are within the tolerance range. The following results were obtained. A design and technological analysis of the blade of the pumped hydroelectric power station was performed, after which a 3D scanner and a 3D printer were selected. A 3D scan of the blade with the formation of a portrait in the STL format file was implemented, as well as its refinement into an ideal one. From the geometric features and shapes of the blade, as well as the technical characteristics of the 3D printer, the percentage of reducing the sample for printing (by 75 % of the original dimensions) was calculated. According to the rated dimensions of the original part and the reduced sample, the tolerance field was set for the size: 0.6 mm and 0.25 mm, respectively, at 12 quality of the part’s manufacturing accuracy. Inspection of the printed sample and comparison with the correspondingly reduced ideal portrait revealed a deviation from –0.123 to +0.120 mm, which is within the defined tolerance field for the manufactured reduced sample. The results of experimental studies confirmed the adequacy of the proposed methodology for prototyping the mechanical engineering parts and verified the theoretical foundations of reverse engineering for convex-concave parts of any large size by using a proportional reduction in the size of finished portraits