bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing Maximal Medical Improvement After Arthroscopic Rotator Cuff Repair
Authors: Zuke William A. , Leroux Timothy S. , Gregory Bonnie P. , Black Austin , Forsythe Brian , Romeo Anthony A. , Verma Nikhil N. 
Published: June 2017

Background: As health care transitions from a pay-for-service to a pay-for-performance infrastructure, the value of orthopaedic care must be defined accurately. Significant efforts have been made in defining quality and cost in arthroplasty; however, there remains a lag in ambulatory orthopaedic care. Purpose: Two-year follow-up has been a general requirement for reporting outcomes after rotator cuff repair. However, this time requirement has not been established scientifically and is of increasing importance in the era of value-based health care. Given that arthroscopic rotator cuff repair is a common ambulatory orthopaedic procedure, the purpose of this study was to establish a time frame for maximal medical improvement (the state when improvement has stabilized) after arthroscopic rotator cuff repair. Study Design: Systematic review. Methods: A systematic review of the literature was conducted, identifying studies reporting sequential patient-reported outcomes up to a minimum of 2 years after arthroscopic rotator cuff repair. The primary clinical outcome was patient-reported outcomes at 3-month, 6-month, 1-year, and 2-year follow-up. Secondary clinical outcomes included range of motion, strength, retears, and complications. Clinically significant improvement was determined between various time intervals by use of the minimal clinically important difference. Results: The review included 19 studies including 1370 patients who underwent rotator cuff repair. Clinically significant improvement in patient-reported outcomes was seen up to 1 year after rotator cuff repair, but no clinical significance was noted from 1 year to 2 years. The majority of improvement in strength and range of motion was seen up to 6 months, but no clinically meaningful improvement was seen thereafter. All reported complications and the majority of retears occurred within 6 months after rotator cuff repair. Conclusion: After rotator cuff repair, a clinically significant improvement in patient-reported outcomes, range of motion, and strength was seen up to 1 year after surgery, but not beyond this. This information is important not only to establish appropriate patient expectations but also to determine a time frame for outcome collection after surgery to better define value in orthopaedic care.
Changes in Cartilage Biomarker Levels During a Transcontinental Multistage Footrace Over 4486 km
Authors: Mündermann Annegret , Klenk Christopher , Billich Christian , Nüesch Corina , Pagenstert Geert , Schmidt-Trucksäss Arno , Schütz Uwe 
Published: June 2017

Background: Cartilage turnover and load-induced tissue changes are frequently assessed by quantifying concentrations of cartilage biomarkers in serum. To date, information on the effects of ultramarathon running on articular cartilage is scarce. Hypothesis: Serum concentrations of cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)–1, MMP-3, MMP-9, COL2-3/4C long mono (C2C), procollagen type II C-terminal propeptide (CPII), and C2C:CPII will increase throughout a multistage ultramarathon. Study Design: Descriptive laboratory study. Methods: Blood samples were collected from 36 runners (4 female; mean age, 49.0 ± 10.7 years; mean body mass index, 23.1 ± 2.3 kg/m2 [start] and 21.4 ± 1.9 kg/m2 [finish]) before (t0) and during (t1: 1002 km; t2: 2132 km; t3: 3234 km; t4: 4039 km) a 4486-km multistage ultramarathon. Serum COMP, MMP-1, MMP-3, MMP-9, C2C, and CPII levels were assessed using commercial enzyme-linked immunosorbent assays. Linear mixed models were used to detect significant changes in serum biomarker levels over time with the time-varying covariates of body weight, running speed, and daily running time. Results: Serum concentrations of COMP, MMP-9, and MMP-3 changed significantly throughout the multistage ultramarathon. On average, concentrations increased during the first measurement interval (MI1: t1-t0) by 22.5% for COMP (95% CI, 0.29-0.71 ng/mL), 22.3% for MMP-3 (95% CI, 0.24-15.37 ng/mL), and 95.6% for MMP-9 (95% CI, 81.7-414.5 ng/mL) and remained stable throughout MI2, MI3, and MI4. Serum concentrations of MMP-1, C2C, CPII, and C2C:CPII did not change significantly throughout the multistage ultramarathon. Changes in MMP-3 were statistically associated with changes in COMP throughout the ultramarathon race (MMP-3: Wald Z = 3.476, P = .001). Conclusion: Elevated COMP levels indicate increased COMP turnover in response to extreme running, and the association between load-induced changes in MMP-3 and changes in COMP suggests the possibility that MMP-3 may be involved in the degradation of COMP. Clinical Relevance: These results suggest that articular cartilage is able to adapt even to extreme physical activity, possibly explaining why the risk of degenerative joint disease is not elevated in the running population.
Late-onset systemic lupus erythematosus: Is it “mild lupus”?
Authors: Sohn I W , Joo Y B , Won S , Bae S C 
Published: June 2017

Objective The objective of this paper is to investigate the clinical characteristics and prognosis of patients with late-onset systemic lupus erythematosus (SLE) using a prospective observational cohort. Methods Late-onset SLE (≥50 years old) was compared with adult-onset SLE (≥18 and <50 years old) using 1997 ACR classification criteria for SLE, autoantibodies, disease activity measured by Adjusted Mean SLE Disease Activity Index (AMS), and damage measured by Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI). The standardized mortality ratio (SMR) was calculated. Results A total of 917 patients with SLE were enrolled. The mean number of cumulative ACR criteria in late-onset SLE ( n = 32, 3.5%) was lower than that in adult-onset SLE (4.6 ± 1.2 vs. 5.5 ± 1.4, p < 0.05). The percentage of patients with low complement was lower in late-onset SLE than adult-onset SLE ( p < 0.05). AMS was also lower in late-onset SLE (2.7 ± 2.1 vs. 4.3 ± 2.6, p < 0.01), but SDI was similar between the two groups (50% vs. 43.4%, p = 0.58). The SMR of late-onset SLE was 1.58 (95% CI 0.58–3.43), while the SMR of adult-onset SLE was 3.34 (2.34–4.63). Conclusion Compared with adult-onset SLE, late-onset SLE has a lower number of ACR criteria and lower disease activity. Organ damage is not different, but prognosis and mortality are more favorable.
Establishing energy requirements for body weight maintenance: validation of an intake-balance method
Authors: Heymsfield Steven B. , Peterson Courtney M. , Thomas Diana M. , Hirezi Michael , Zhang Bo , Smith Steven , Bray George , Redman Leanne 
Published: June 2017

Abstract
Background
Experimentally establishing a group’s body weight maintenance energy requirement is an important component of metabolism research. At present, the reference approach for measuring the metabolizable energy intake (MEI) from foods required for body weight maintenance in non-confined subjects is the doubly-labeled water (DLW)–total energy expenditure (TEE) method. In the current study, we evaluated an energy-intake weight balance method as an alternative to DLW that is more flexible and practical to apply in some settings.

Methods
The hypothesis was tested that MEI from foods observed in a group of subjects maintaining a constant energy intake while keeping their weight within ±1 kg over 10 days is non-significantly different from DLW-measured TEE (TEEDLW). Six non-obese subjects evaluated as part of an earlier study completed the inpatient protocol that included a 3-day initial adjustment period.

Results
The group body weight coefficient of variation (X ± SD) during the 10-day balance period was 0.38 ± 0.10% and the slope of the regression line for body weight versus protocol day was non-significant at 1.8 g/day (R2, 0.002, p = 0.98). MEI from foods observed during the 10-day balance period (2390 ± 543 kcal/day) was non-significantly different (p = 0.96) from TEE measured by DLW (2373 ± 713 kcal/day); the MEI/TEEDLW ratio was 1.03 ± 0.15 (range 0.87–1.27) and the correlation between MEI from foods and TEEDLW was highly significant (R2, 0.88, p = 0.005).

Conclusions
A carefully managed 10-day protocol that includes a constant MEI level from foods with weight stability (±1 kg) will provide a group’s body weight maintenance energy requirement similar to that obtained with DLW. This approach opens the possibility of conducting affordable weight balance studies, shorter in duration than those previously reported, that are needed to answer a wide range of questions in clinical nutrition.
Trial registration The study is registered at http://www.clinicaltrials.gov (NCT01672632; August 20, 2012).
Emerging roles of mechanical forces in chromatin regulation
Authors: Miroshnikova Yekaterina A. , Nava Michele M. , Wickström Sara A. 
Published: June 2017

ABSTRACT
Cells are constantly subjected to a spectrum of mechanical cues, such as shear stress, compression, differential tissue rigidity and strain, to which they adapt by engaging mechanisms of mechanotransduction. While the central role of cell adhesion receptors in this process is established, it has only recently been appreciated that mechanical cues reach far beyond the plasma membrane and the cytoskeleton, and are directly transmitted to the nucleus. Furthermore, changes in the mechanical properties of the perinuclear cytoskeleton, nuclear lamina and chromatin are critical for cellular responses and adaptation to external mechanical cues. In that respect, dynamic changes in the nuclear lamina and the surrounding cytoskeleton modify mechanical properties of the nucleus, thereby protecting genetic material from damage. The importance of this mechanism is highlighted by debilitating genetic diseases, termed laminopathies, that result from impaired mechanoresistance of the nuclear lamina. What has been less evident, and represents one of the exciting emerging concepts, is that chromatin itself is an active rheological element of the nucleus, which undergoes dynamic changes upon application of force, thereby facilitating cellular adaption to differential force environments. This Review aims to highlight these emerging concepts by discussing the latest literature in this area and by proposing an integrative model of cytoskeletal and chromatin-mediated responses to mechanical stress.
Polyaniline/MoSX Supercapacitor by Electrodeposition
Authors: Wang Yong , Mayorga-Martinez Carmen C , Pumera Martin 
Published: June 2017

Abstract
Supercapacitors as a promising energy storage device have received significant attention. Here we report a facile, low cost and mass production strategy to prepare polyaniline (PANI)/molybdenum sulfide (MoSX) supercapacitor material by electrodeposition. More specifically, PANI was electrodeposited on glassy carbon (GC) through chrono amperometry followed by electrodeposition of MoSX via chrono potentiometry from ammonium tetrathiomolybdate ((NH4)2MoS4) precursor. This composite material was characterized by X-ray photoelectron spectrum, scanning electron microscopy and energy-dispersive X-ray spectroscopy. In addition, PANI/MoSX shows superior capacitance of 48.64 mF cm−2 at a current density of 56.62 µA cm−2 and long-term stability without any degradation during the 150 cycles. The enhanced capacitance observed is from the combination of electrochemical behaviors of PANI and MoSX.
Assessment of injection safety in Ha Dong General Hospital, Hanoi, in 2012
Authors: Van Tuong Phan , Phuong Tran Thi Minh , Anh Bui Thi My , Nguyen Trang Huyen Thi 
Published: June 2017

Background: Injection is one of the most frequently used medical methods to introduce drugs or other substances into the body for purposes of treatment or prevention. Unsafe injection can cause adverse outcomes, such as abscess and anaphylactic shock, and increases the risk of blood-borne transmission of viruses to patients and health care workers, as well as the community. Recognizing the importance of injection safety, in 2000 the Vietnamese Ministry of Health (MOH) collaborated with the Vietnam Nurses Association to launch the “Safe injection” program throughout the country, including Hanoi. Methods: This cross-sectional study, combining quantitative and qualitative analysis, was conducted from February to August 2012 in Ha Dong General Hospital using a structured questionnaire and observation checklist. The target population of the study was 109 nurses working in clinical departments and 436 injections were observed. Results: The percentage of nurses who are familiar with injection safety standards was found to be 82.6%. The proportion of practical injections that met the 23 standards of injection safety set by the MOH amounted to 22.2%. The factors related to safe injection practice of nurses who are younger age group (OR=3.1; p<0.05) and lower amount of working years (OR=2.8; p<0.05). Conclusions: A low proportion of nurses performed correct safety injection practice, which raises the need for further training about this issue, especially among older nurses.
ПОНЯТИЕ КРАСОТЫ, ВЫРАЖЕННОЕ В СЛОВАХ ЭТИМОЛОГИЧЕСКОГО ГНЕЗДА ИНДОЕВРОПЕЙСКОГО КОРНЯ *LEIP
Authors: Galochkina Tatiana Anatolevna 
Published: June 2017

Когнитивный подход к исследованию семантического развития слов обеспечивает более емкое описание их значений, особенно переносных, выраженных, как правило, в виде метафор.В статье описывается значение концептуальной метафоры в качестве инструмента исследования семантики слов со значением красоты, входящих в этимологическое гнездо индоевропейского корня *leip. Показана модель причинно-следственной связи между значением слов и концептуальным мышлением.Цель. Статья посвящена актуальному в настоящее время направлению в лингвистике – когнитивной семантике. Автор раскрывает семантическую взаимосвязь слов, входящих в этимологическое гнездо индоевропейского корня *leip, с использованием концептуальной метафоры.Метод или методология проведения работы. Основу исследования образуют аналитический и герменевтический методы.Результаты. Автор доказывает причинно-следственную связь между значением слов и концептуальным мышлением.Область применения результатов. Результаты работы могут быть использованы при составлении этимологических словарей.
Childhood Illness and the Gender Gap in Adolescent Education in Low- and Middle-Income Countries
Authors: Alsan Marcella , Xing Anlu , Wise Paul , Darmstadt Gary L. , Bendavid Eran 
Published: June 2017

BACKGROUND:
Achieving gender equality in education is an important development goal. We tested the hypothesis that the gender gap in adolescent education is accentuated by illnesses among young children in the household.

METHODS:
Using Demographic and Health Surveys on 41 821 households in 38 low- and middle-income countries, we used linear regression to estimate the difference in the probability adolescent girls and boys were in school, and how this gap responded to illness episodes among children &lt;5 years old. To test the hypothesis that investments in child health are related to the gender gap in education, we assessed the relationship between the gender gap and national immunization coverage.

RESULTS:
In our sample of 120 708 adolescent boys and girls residing in 38 countries, girls were 5.08% less likely to attend school than boys in the absence of a recent illness among young children within the same household (95% confidence interval [CI], 5.50%–4.65%). This gap increased to 7.77% (95% CI, 8.24%–7.30%) and 8.53% (95% CI, 9.32%–7.74%) if the household reported 1 and 2 or more illness episodes, respectively. The gender gap in schooling in response to illness was larger in households with a working mother. Increases in child vaccination rates were associated with a closing of the gender gap in schooling (correlation coefficient = 0.34, P = .02).

CONCLUSIONS:
Illnesses among children strongly predict a widening of the gender gap in education. Investments in early childhood health may have important effects on schooling attainment for adolescent girls.
Is there a relationship between increased aortic stiffness and segmental left ventricular deformation in elite athletes? (Insights from the MAGYAR-Sport Study)
Authors: Nemes A , Kalapos A , Domsik P , Oszlánczi M , Lengyel C , Balogh L , Forster T 
Published: June 2017

Introduction
Myocardial contractility of the left ventricle (LV) is related to arterial distensibility. Sport activity is frequently associated with changes in both LV and arterial functions. This study aimed to find correlations between three-dimensional speckle-tracking echocardiography-derived segmental LV deformation parameters and echocardiographically assessed aortic stiffness index (ASI) in athletes. This study comprised 26 young elite athletes (mean age: 26.7 ± 8.4 years, nine men).

Results
Among segmental circumferential strains (CSs), only that of apical anterior (r = 0.40, p = 0.05), septal (r = 0.47, p = 0.01), inferior (r = 0.59, p = 0.001), lateral (r = 0.44, p < 0.05), and midventricular anteroseptal (r = 0.44, p < 0.05) segments correlated with ASI, whereas LV-CS of the midventricular anterior segment showed a correlation tendency. Only longitudinal strain of basal anteroseptal (r = −0.46, p < 0.05) and inferoseptal (r = −0.57, p < 0.01) segments showed correlations with ASI, whereas that of the basal anterior segment had only a tendency to correlate. Some segmental multidirectional strains also correlated with ASI.

Conclusions
Correlations could be demonstrated between increased aortic stiffness and circular function of the apical and midventricular LV fibers and longitudinal motion of the basal septum and LV anterior wall (part of LV outflow tract) in maintaining circulation in the elite athletes.
PREVALENCE OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, OPPOSITIONAL DEFIANT DISORDER AND CONDUCT DISORDER IN CHILDREN WITH AUTISM SPECTRUM DISORDER
Authors: Pondé Milena Pereira , Matos Mirella Lins , Oliveira Cinthia Cristina Pinto Bispo de 
Published: June 2017

Aim: To estimate the prevalence of attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD) and conduct disorder (CD) in children and adolescents previously diagnosed with autism spectrum disorder (ASD). Methods: A cross-sectional study involving 71 children and adolescents previously diagnosed by a psychiatrist as having ASD. All were enrolled at a school that accompanies only individuals with ASD. The evaluation instruments consisted of a sociodemographic questionnaire and the Brazilian version of the semi-structured interview Kiddie-SADS-PL for the investigation of psychiatric disorders in children and adolescents. Results: Overall, 62% of the children in the sample had some psychiatric comorbidity: 49.3% had some form of ADHD, 11.3% ODD and 1.4% CD. In relation to the children with ADHD, 11.3% fulfilled the criteria for the inattentive subtype, 12.7% for the hyperactive/impulsive subtype, 7.1% for the combined subtype and 18.3% for ADHD not otherwise specified. Conclusion: These results ratify the clinical heterogeneity of ASD and highlight the importance of diagnosing comorbidities that could affect the clinical status and functioning level of children and adolescents with ASD.
A Look into a Professional Learning Community
Authors: Dehdary Nazanin 
Published: June 2017

Professional learning communities are not commonplace in Iran and this is evidenced by the scant literature in this regard. The present study is an attempt to fill the gap in the literature. This study was conducted in the hope of evaluating a professional learning community within an English language institute in Iran to detect the threats to its survival from the viewpoints of some of the teachers and members of the board of studies. The analysis of the data uncovered three major strengths the current PLC enjoys. These plus points are the dynamic work context, management policy, and a nexus of focus communities. There is, however, a consensus among participants that in recent years many teachers have detached themselves from different communities within the institute. The analysis of the data revealed sense of belonging, teacher’s view of the profession, infrastructure and flawed dialogue as the major threats.
Discurso opositivo e ironia na página "Humans of Protesto" / Oppositional speech and irony at the page "humans of protesto"
Authors: Serrano Paulo Henrique 
Published: June 2017

RESUMO: A página do Facebook Humans of Protesto expõe de forma irônica os atores apresentados como mais incoerentes e bizarros das manifestações ocorridas principalmente em 15 de março e 12 de abril de 2015, lideradas pelo Movimento Brasil Livre, Vem Pra Rua e Revoltados On Line. A estratégia de argumentação realizada para desqualificar os protestos e qualificar negativamente seus participantes é analisada neste artigo com base nas definições de Perelman & Olbrechts-Tyteca (2005) sobre os lugares comuns e os discursos retóricos, diferentes formas de argumentação. O estudo possibilita a compreensão de como as estratégias de discurso net-ativista promovidas pela página analisada são construídas para aumentar a adesão de quem acessa seu conteúdo. ABSTRACT: The Facebook page Humans of Protesto exposes in an ironic way the more inconsistent and bizarre characters of demonstrations mainly occurred in March 15th and April 12th of 2015, led by Movimento Brasil Livre, Vem Pra Rua and Revoltados On Line. The strategy of argumentation carried out to discredit the protests and negatively qualify its participants is analyzed based on the definitions of Perelman & Olbrechts-Tyteca (2005) about platitudes and rhetorical speeches, different forms of argumenting. The study allows the understanding of how speech strategies promoted by that page is built to increase the support of those who access its contents.
O Popol Wuj como ferramenta de ensino na era da informação / The Popol Wuj as a tool to learn at the age of information
Authors: Barrera Conrad Sackl Ana Maria 
Published: June 2017

RESUMO:Este artigo aborda o devir do Manuscrito do Popol Wuj (XIMÉNEZ, 1700) de origem pré-hispânica, um dos textos mais antigos das Américas, sobrevivente da colonização espanhola e conservado até a era da informação. Justifica-se seu estudo pelo fato de a obra ser largamente utilizada nas escolas da América Latina, porém pouco aproveitada no Brasil. O objetivo deste artigo é descrever alguns detalhes do trabalho de restauração do manuscrito na Newberry Library de Chicago e sua posterior digitalização na Universidade de Ohio (The Ohio State University), abordar algumas características ontológicas do manuscrito e do documento digitalizado e comentar as funcionalidades de ambas a partir do ponto de vista de autores como Genette (2009) e Biasi (2007 e 2010). Finalmente pesquisa-se a epistemologia do texto maia por considerá-lo um aporte para as discussões sobre novos paradigmas a respeito da ecologia, seguindo as considerações de di Felice (2012) sobre redes de informação. Nessa perspectiva, propõe-se que o Popol Wuj é uma ferramenta didática para o ensino interdisciplinar e intercultural. ABSTRACT:This article deals with the topic of the historical path and the future of the Popol Wuj (Ximénez, 1700), a mythic manuscript that survived the Spanish colonization. Considered to be one of the oldest Pre-Hispanic texts found in the Americas, the book has remained preserved till our Information Age. The text, widely used in Latin-American schools, is not yet well known in Brazil. The goal of this research is to understand the epistemology of the text, considering it appropriate for an ecological education, in accordance with the Net Information concepts from Massimo di Felice (2012).The article also describes some details of the restoration of the manuscript and its digitalization, done at Ohio State University. After a commentary on the ontological and functional characteristics of the manuscript and its digitalized copies, taken from the point of view of authors like Genette (2009) and Biasi (2007 e 2010), we point out that the Popol-Wuj is an efficient tool for interdisciplinary and intercultural teaching.