bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mouse Universal Genotyping Array: From Substrains to Subspecies
Authors: Morgan Andrew P , Fu Chen-Ping , Kao Chia-Yu , Welsh Catherine E , Didion John P , Yadgary Liran , Hyacinth Leeanna , Ferris Martin T , Bell Timothy A , Miller Darla R , Giusti-Rodriguez Paola , Nonneman Randal J , Cook Kevin D , Whitmire Jason K , Gralinski Lisa E , Keller Mark , Attie Alan D , Churchill Gary A , Petkov Petko , Sullivan Patrick F , Brennan Jennifer R , McMillan Leonard , Pardo-Manuel de Villena Fernando 
Published: December 2015

Abstract
Genotyping microarrays are an important resource for genetic mapping, population genetics, and monitoring of the genetic integrity of laboratory stocks. We have developed the third generation of the Mouse Universal Genotyping Array (MUGA) series, GigaMUGA, a 143,259-probe Illumina Infinium II array for the house mouse (Mus musculus). The bulk of the content of GigaMUGA is optimized for genetic mapping in the Collaborative Cross and Diversity Outbred populations, and for substrain-level identification of laboratory mice. In addition to 141,090 single nucleotide polymorphism probes, GigaMUGA contains 2006 probes for copy number concentrated in structurally polymorphic regions of the mouse genome. The performance of the array is characterized in a set of 500 high-quality reference samples spanning laboratory inbred strains, recombinant inbred lines, outbred stocks, and wild-caught mice. GigaMUGA is highly informative across a wide range of genetically diverse samples, from laboratory substrains to other Mus species. In addition to describing the content and performance of the array, we provide detailed probe-level annotation and recommendations for quality control.
argyle: An R Package for Analysis of Illumina Genotyping Arrays
Authors: Morgan Andrew P 
Published: December 2015

Abstract
Genotyping microarrays are an important and widely-used tool in genetics. I present argyle, an R package for analysis of genotyping array data tailored to Illumina arrays. The goal of the argyle package is to provide simple, expressive tools for nonexpert users to perform quality checks and exploratory analyses of genotyping data. To these ends, the package consists of a suite of quality-control functions, normalization procedures, and utilities for visually and statistically summarizing such data. Format-conversion tools allow interoperability with popular software packages for analysis of genetic data including PLINK, R/qtl and DOQTL. Detailed vignettes demonstrating common use cases are included as supporting information. argyle bridges the gap between the low-level tasks of quality control and high-level tasks of genetic analysis. It is freely available at https://github.com/andrewparkermorgan/argyle and has been submitted to Bioconductor.
An Amphiphysin-Like Domain in Fus2p Is Required for Rvs161p Interaction and Cortical Localization
Authors: Stein Richard A , Smith Jean A , Rose Mark D 
Published: December 2015

AbstractCell–cell fusion fulfils essential roles in fertilization, development and tissue repair. In the budding yeast, Saccharomyces cerevisiae, fusion between two haploid cells of opposite mating type generates the diploid zygote. Fus2p is a pheromone-induced protein that regulates cell wall removal during mating. Fus2p shuttles from the nucleus to localize at the shmoo tip, bound to Rvs161p, an amphiphysin. However, Rvs161p independently binds a second amphiphysin, Rvs167p, playing an essential role in endocytosis. To understand the basis of the Fus2p–Rvs161p interaction, we analyzed Fus2p structural domains. A previously described N-terminal domain (NTD) is necessary and sufficient to regulate nuclear/cytoplasmic trafficking of Fus2p. The Dbl homology domain (DBH) binds GTP-bound Cdc42p; binding is required for cell fusion, but not localization. We identified an approximately 200 amino acid region of Fus2p that is both necessary and sufficient for Rvs161p binding. The Rvs161p binding domain (RBD) contains three predicted alpha-helices; structural modeling suggests that the RBD adopts an amphiphysin-like structure. The RBD contains a 13-amino-acid region, conserved with Rvs161p and other amphiphysins, which is essential for binding. Mutations in the RBD, predicted to affect membrane binding, abolish cell fusion without affecting Rvs161p binding. We propose that Fus2p/Rvs161p form a novel heterodimeric amphiphysin required for cell fusion. Rvs161p binding is required but not sufficient for Fus2p localization. Mutations in the C-terminal domain (CTD) of Fus2p block localization, but not Rvs161p binding, causing a significant defect in cell fusion. We conclude that the Fus2p CTD mediates an additional, Rvs161p-independent interaction at the shmoo tip.
Genetic Determinants of RNA Editing Levels of ADAR Targets in Drosophila melanogaster
Authors: Kurmangaliyev Yerbol Z , Ali Sammi , Nuzhdin Sergey V 
Published: December 2015

Abstract
RNA editing usually affects only a fraction of expressed transcripts and there is a vast amount of variation in editing levels of ADAR (adenosine deaminase, RNA-specific) targets. Here we explore natural genetic variation affecting editing levels of particular sites in 81 natural strains of Drosophila melanogaster. The analysis of associations between editing levels and single-nucleotide polymorphisms allows us to map putative cis-regulatory regions affecting editing of 16 A-to-I editing sites (cis-RNA editing quantitative trait loci or cis-edQTLs, P &lt; 10−8). The observed changes in editing levels are validated by independent molecular technique. All identified regulatory variants are located in close proximity of modulated editing sites. Moreover, colocalized editing sites are often regulated by same loci. Similar to expression and splicing QTL studies, the characterization of edQTLs will greatly expand our understanding of cis-regulatory evolution of gene expression.
‘Wanting’ and ‘liking’ skin picking: A validation of the Skin Picking Reward Scale
Authors: Snorrason Ivar , Olafsson Ragnar P. , Houghton David C. , Woods Douglas W. , Lee Han-Joo 
Published: December 2015

Background and Aims
Excoriation (skin-picking) disorder (SPD) is often conceptualized as a behavioral addiction in which aberrant reward processing may play an important role. The current study sought to develop a self-report instrument – the Skin Picking Reward Scale (SPRS) – that measures how strongly skin picking is ‘liked’ (i.e., the degree of pleasurable feelings while receiving the reward) and ‘wanted’ (i.e., the degree of the motivation to seek the reward).

Methods
We administered the SPRS to individuals who endorsed excessive skin picking in online surveys and examined the scale’s factor structure (Studies 1 and 2). We then asked individuals with documented pathological skin picking to complete the SPRS and other relevant questionnaires on two occasions one week apart (Study 3).

Results
Exploratory (Study 1; n = 330) and confirmatory (Study 2; n = 144) factor analyses consistently supported a two-factor structure reflecting the ‘liking’ and ‘wanting’ constructs. Results from Study 3 (N = 36) indicated that the Wanting and the Liking scales had adequate internal consistency and test–retest reliability. Additionally, consistent with predictions, the Wanting scale, but not the Liking scale, was associated with picking urges the following week, greater cue-reactivity, and more picking-related routines/habits.

Discussion
These initial findings suggest that SPRS is a psychometrically sound measure of ‘wanting’ and ‘liking’ in pathological skin picking. The SPRS may facilitate research on reward processing anomalies in SPD and serve as a useful clinical instrument (e.g., to identify those at risk for cue-induced relapse).
Smartphone use and smartphone addiction among young people in Switzerland
Authors: Haug Severin , Castro Raquel Paz , Kwon Min , Filler Andreas , Kowatsch Tobias , Schaub Michael P. 
Published: December 2015

Background and Aims
Smartphone addiction, its association with smartphone use, and its predictors have not yet been studied in a European sample. This study investigated indicators of smartphone use, smartphone addiction, and their associations with demographic and health behaviour-related variables in young people.

Methods
A convenience sample of 1,519 students from 127 Swiss vocational school classes participated in a survey assessing demographic and health-related characteristics as well as indicators of smartphone use and addiction. Smartphone addiction was assessed using a short version of the Smartphone Addiction Scale for Adolescents (SAS-SV). Logistic regression analyses were conducted to investigate demographic and health-related predictors of smartphone addiction.

Results
Smartphone addiction occurred in 256 (16.9%) of the 1,519 students. Longer duration of smartphone use on a typical day, a shorter time period until first smartphone use in the morning, and reporting that social networking was the most personally relevant smartphone function were associated with smartphone addiction. Smartphone addiction was more prevalent in younger adolescents (15–16 years) compared with young adults (19 years and older), students with both parents born outside Switzerland, persons reporting lower physical activity, and those reporting higher stress. Alcohol and tobacco consumption were unrelated to smartphone addiction.

Discussion
Different indicators of smartphone use are associated with smartphone addiction and subgroups of young people have a higher prevalence of smartphone addiction.

Conclusions
The study provides the first insights into smartphone use, smartphone addiction, and predictors of smartphone addiction in young people from a European country, which should be extended in further studies.
Comparison of risk and protective factors associated with smartphone addiction and Internet addiction
Authors: Choi Sam-Wook , Kim Dai-Jin , Choi Jung-Seok , Ahn Heejune , Choi Eun-Jeung , Song Won-Young , Kim Seohee , Youn Hyunchul 
Published: December 2015

Background and Aims
Smartphone addiction is a recent concern that has resulted from the dramatic increase in worldwide smartphone use. This study assessed the risk and protective factors associated with smartphone addiction in college students and compared these factors to those linked to Internet addiction.

Methods
College students (N = 448) in South Korea completed the Smartphone Addiction Scale, the Young’s Internet Addiction Test, the Alcohol Use Disorders Identification Test, the Beck Depression Inventory I, the State–Trait Anxiety Inventory (Trait Version), the Character Strengths Test, and the Connor–Davidson Resilience Scale. The data were analyzed using multiple linear regression analyses.

Results
The risk factors for smartphone addiction were female gender, Internet use, alcohol use, and anxiety, while the protective factors were depression and temperance. In contrast, the risk factors for Internet addiction were male gender, smartphone use, anxiety, and wisdom/knowledge, while the protective factor was courage.

Discussion
These differences may result from unique features of smartphones, such as high availability and primary use as a tool for interpersonal relationships.

Conclusions
Our findings will aid clinicians in distinguishing between predictive factors for smartphone and Internet addiction and can consequently be utilized in the prevention and treatment of smartphone addiction.
Publicity and reports of behavioral addictions associated with dopamine agonists
Authors: Gendreau Katherine E. , Potenza Marc N. 
Published: December 2015

Background
The development of behavioral addictions (BAs) in association with dopamine agonists (DAs, commonly used to treat Parkinson’s disease) has been reported. A recent report presented data that these associations are evident in the US Food and Drug Administration’s (FDA) Adverse Event Reporting System (FAERS), a database containing information on adverse drug event and medication error reports submitted to the FDA. However, given that vulnerability to publicity-stimulated reporting is a potential limitation of spontaneous reporting systems like the FAERS, the potential impact of publicity on reporting in this case remains unclear.

Method and aims
To investigate the potential impact of publicity on FAERS reporting of BAs in association with DAs (BAs w/DAs) as presented by Moore, Glenmullen, and Mattison (2014), news stories covering a BA/DA association were identified and compared with BA w/DA and other reporting data in the FAERS.

Results
Fluctuations in the growth of BA w/DA reporting to the FAERS between 2003 and 2012 appear to coincide with multiple periods of intensive media coverage of a BA/DA association, a pattern that is not evident in other reporting data in the FAERS.

Discussion/Conclusions
Publicity may stimulate reporting of adverse events and premature dismissal of the potential influence of publicity on reporting may lead to mistaking an increased risk of an adverse event being reported for an increased risk of an adverse event occurring.
Interpersonal dependency and online gaming addiction
Authors: Škařupová Kateřina , Blinka Lukas 
Published: December 2015

Background and aims
The present study explores the relationship between social motivations and addiction to online gaming and if that possible connection can be explained by the personality traits responsible for social functioning.

Methods
We employ Bernstein’s concept of interpersonal dependency to distinguish healthy dependency, dysfunctional detachment, and destructive overdependence, and Charlton and Danforth’s conceptualisation of online gaming addiction and high engagement. An online questionnaire was administered to a self-nominated sample of 4,074 online gamers. Two regression models were constructed to separately explain gaming addiction and high engagement using social motivations to play, while controlling for age, gender, and time spent online.

Results
High scores on subscales measuring dysfunctional detachment and destructive overdependence were positively associated with online gaming addiction, while healthy dependency was negatively correlated with addiction scores. In contrast, the overall role of social motivation was negligible.

Discussion
People with healthy relationship profiles are less likely to develop problematic patterns of online gaming. High in-game engagement, although sharing some factors with addiction, was only poorly explained by the study variables, suggesting the mutual exclusiveness of addiction and engagement.
La ciudad pervertida/Urbanismo neoliberal, negocio inmobiliario y vida vecinal
Authors: Pujades Joan Josep 
Published: December 2015

<p>Ressenya dels llibres: </p><p class="p1">Cucó, Josep (Comp.) (2013), La ciudad pervertida. Una mirada sobre la Valencia global. Barcelona, Anthropos.</p><p class="p1">Franquesa, Jaume (2013), Urbanismo neoliberal, negocio inmobiliario y vida vecinal. El caso de Palma. Barcelona, Icaria.</p>
Proposta de estimulación sensorial na contorna natural dun cativo con trastorno de espectro autista
Authors: Fraga Berta , López Beatriz 
Published: December 2015

Os trastornos do espectro autista supoñen unha afectación nas competencias sociais, comunicativas e lingüísticas que provocan alteracións tanto psicolóxicas como condutuais na persoa e que varían considerablemente duns individuos a outros. Na maioría dos casos existe unha característica común e que se postula como un dos primeiros síntomas de diagnóstico en idades temperás, referímonos a existencia dunha desorde sensorial que lles ocasiona ás persoas con autismo grandes dificultades para poder adaptarse ao mundo que lles rodea e un continuo malestar no seu día a día; estes problemas de integración sensorial pálpanse na incapacidade destas persoas para desenrolar actividades cotiás e para conxugar os diferentes estímulos que reciben do medio elaborando respostas axeitadas e adaptadas. Dende a Asociación DISMACOR sempre temos apostado pola inclusión total de tódalas persoas con diversidade funcional, buscando a máxima potencialidade das súas propias características e a melloría da súa calidade de vida e da das persoas que as rodean; para o que establecemos programas completamente individualizados e adaptados ás necesidades e demandas das persoas e as súas familias, así como unha intervención levada a cabo nas contornas próximas á persoa, onde atopamos unha maior posibilidade de xeralización dos resultados e das competencias adquiridas. Neste sentido, no presente traballo recollemos unha proposta de intervención en contorna natural onde o principal obxectivo é a estimulación multisensorial dun cativo de seis anos con múltiples dificultades para a integración perceptiva, que se concretan en problemas psicomotores, falta de autonomía e dificultades de adaptación ao medio. A metodoloxía seguida baséase na participación guiada dos pais e coidadores habituais do neno mediante a utilización de obxectos cotiás e materiais adaptados á problemática do cativo de cara a conseguir un mellor autocoñecemento do seu corpo e a aprendizaxe de comportamentos que lle permitan unha mellor adaptación ás dinámicas sociais ás que se enfronta a diario. Para a avaliación do seguimento desta intervención farase unha análise cualitativo dos obxectivos plantexados grazas a revisión de escalas e manuais de desenvolvemento. Os resultados obtidos mostran unha mellora significativa no funcionamento adaptativo e na autonomía do neno en todos os seus contextos de referencia. Ademais, este tipo de metodoloxía permiten unha aprendizaxe funcional moito mais áxil e significativa nunha contorna menos estructurada e máis motivante.
Daqui e de lá: empréstimos de leituras e imagens para as revistas literárias do México na primeira metade do século XIX
Authors: Suárez de la Torre Laura 
Published: December 2015

À maneira de um projeto cultural, as revistas literárias ofereceram novidades editoriais relacionadas com edições europeias. Minha proposta enfoca o segundo eixo da convocatória do colóquio, ou seja, o das transferências, empréstimos, adaptações e traduções. A partir das revistas literárias proponho mostrar a circulação de leituras e imagens da Europa em direção à América e visualizar o projeto político-cultural que os redatores pretendiam instaurar. This work is licensed under a Creative Commons Attribution 3.0 License.
Contextual Predictors of Injection Drug Use Among Black Adolescents and Adults in US Metropolitan Areas, 1993–2007
Authors: Cooper Hannah L. F. , West Brooke , Linton Sabriya , Hunter-Jones Josalin , Zlotorzynska Maria , Stall Ron , Wolfe Mary E. , Williams Leslie , Hall H. Irene , Cleland Charles , Tempalski Barbara , Friedman Samuel R. 
Published: December 2015

Objectives. We sought to determine whether contextual factors shape injection drug use among Black adolescents and adults.Methods. For this longitudinal study of 95 US metropolitan statistical areas (MSAs), we drew annual MSA-specific estimates of the prevalence of injection drug use (IDU) among Black adolescents and adults in 1993 through 2007 from 3 surveillance databases. We used existing administrative data to measure MSA-level socioeconomic status; criminal justice activities; expenditures on social welfare, health, and policing; and histories of Black uprisings (1960–1969) and urban renewal funding (1949–1974). We regressed Black IDU prevalence on these predictors by using hierarchical linear models.Results. Black IDU prevalence was lower in MSAs with declining Black high-school dropout rates, a history of Black uprisings, higher percentages of Black residents, and, in MSAs where 1992 White income was high, higher 1992 Black income. Incarceration rates were unrelated.Conclusions. Contextual factors shape patterns of drug use among Black individuals. Structural interventions, especially those that improve Black socioeconomic security and political strength, may help reduce IDU among Black adolescents and adults.
Interest Group Conflict Over Medicaid Expansion: The Surprising Impact of Public Advocates
Authors: Callaghan Timothy , Jacobs Lawrence R. 
Published: December 2015

Objectives. We examined the potential economic, policy, and political influences on the decisions of the 50 US states to expand Medicaid under the Affordable Care Act.Methods. We related a measure of relative state progress toward Medicaid expansion updated to 2015 to each state’s economic circumstances, established policy frameworks in states, partisan control of state government, and lobbyists for businesses, medical professionals, unions, and public interest organizations.Results. The 9201 lobbyists working on health care reform in state capitols exerted a strong and significant impact on Medicaid expansion. Controlling for confounding factors (including partisanship and existing policy frameworks), we found that business and professional lobbyists exerted a negative effect on state Medicaid expansion and, unexpectedly, that public interest advocates exerted a positive effect.Conclusions. There are 3.1 million adults who lack coverage because they live in the 20 states that refused to expand Medicaid. Although political party and lobbyists for private interests present significant barriers in these states, legislative lobbying on behalf of the uninsured appears likely to be effective.
Ethics and Childhood Vaccination Policy in the United States
Authors: Hendrix Kristin S. , Sturm Lynne A. , Zimet Gregory D. , Meslin Eric M. 
Published: December 2015

Childhood immunization involves a balance between parents’ autonomy in deciding whether to immunize their children and the benefits to public health from mandating vaccines. Ethical concerns about pediatric vaccination span several public health domains, including those of policymakers, clinicians, and other professionals. In light of ongoing developments and debates, we discuss several key ethical issues concerning childhood immunization in the United States and describe how they affect policy development and clinical practice. We focus on ethical considerations pertaining to herd immunity as a community good, vaccine communication, dismissal of vaccine-refusing families from practice, and vaccine mandates. Clinicians and policymakers need to consider the nature and timing of vaccine-related discussions and invoke deliberative approaches to policymaking.
Opioid Overdose Deaths and Florida’s Crackdown on Pill Mills
Authors: Kennedy-Hendricks Alene , Richey Matthew , McGinty Emma E. , Stuart Elizabeth A. , Barry Colleen L. , Webster Daniel W. 
Published: December 2015

Objectives. We examined the effect on opioid overdose mortality of Florida state laws and law enforcement operations targeting “pill mills.” Methods. We collected 2003 to 2012 mortality data from the Florida Department of Health and the North Carolina State Center for Health Statistics (the comparison state) to estimate changes in the rates of death from prescription opioid, heroin, or any opioid overdose. Results. Florida’s actions were associated with an estimated 1029 lives saved from prescription opioid overdose over a 34-month period. Estimated reductions in deaths grew over the intervention period, with rates per 100 000 population that were 0.6 lower in 2010, 1.8 lower in 2011, and 3.0 lower in 2012 than what would have been expected had the changes in mortality rate trends in Florida been the same as changes in trends in North Carolina. Florida’s mortality rates from heroin and total opioid overdose were also lower than anticipated relative to changes in trends in North Carolina. Conclusions. Findings from this study indicate that laws regulating pain clinics and enforcement of these laws may, in combination, reduce opioid overdose deaths.