bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Reframing Healthcare Services through the Lens of Co-Production’ (RheLaunCh): a study protocol for a mixed methods evaluation of mechanisms by which healthcare and social services impact the health and well-being of patients with COPD and CHF in the USA and The Netherlands
Authors: Hesselink Gijs , Johnson Julie , Batalden Paul , Carlson Michelle , Geense Wytske , Groenewoud Stef , Jones Sylvester , Roy Brita , Sansone Christina , Wolf Judith R L M , Bart Bradley , Wollersheim Hub 
Published: September 2017

IntroductionThe USA lags behind other high-income countries in many health indicators. Outcome differences are associated with differences in the relative spending between healthcare and social services at the national level. The impact of the ratio and delivery of social and healthcare services on the individual patient’s health is however unknown. ‘Reframing Healthcare Services through the Lens of Co-Production’ (RheLaunCh) will be a cross-Atlantic comparative study of the mechanisms by which healthcare and social service delivery may impact patient health with chronic conditions. Insight into these mechanisms is needed to better and cost-effectively organise healthcare and social services.MethodsWe designed a mixed methods study to compare the socioeconomic background, needs of and service delivery to patients with congestive heart failure and chronic obstructive pulmonary disease in the USA and the Netherlands. We will conduct: (1) a literature scan to compare national and regional healthcare and social service systems; (2) a retrospective database study to compare patient’s socioeconomic and clinical characteristics and the service use and spending at the national, regional and hospital level; (3) a survey to compare patient perceived quality of life, receipt and experience of service delivery and ability of these services to meet patient needs; and (4) multiple case studies to understand what patients need to better govern their quality of life and how needs are met by services.Ethics and disseminationEthics approval was granted by the ethics committee of the Radboud University Medical Center (2016–2423) in the Netherlands and by the Human Subjects Research Committee of the Hennepin Health Care System, Inc. (HSR #16–4230) in the USA. Multiple approaches will be used for dissemination of results, including (inter)national research presentations and peer-reviewed publications. A website will be established to support the development of a community of practice.
Design of a wide band metasurface as a linear to circular polarization converter
Authors: Altintas Olcay , Unal Emin , Akgol Oguzhan , Karaaslan Muharrem , Karadag Faruk , Sabah Cumali 
Published: September 2017

In this paper, we present a wide band metasurface (MS) polarization converter which converts a linearly polarized signal to a right-handed or left-handed circularly polarized signal both numerically and experimentally. The unit cell of MS has three nested rectangular resonators which have two metallic patches at its crossed corners. The simulated and measured results are achieved by a commercial full wave EM simulator and a vector network analyzer with two horn antennas in microwave frequency regime. The S-parameters are obtained for co-polarized and cross-polarized responses and axial ratio is evaluated by the division of these two responses. The axial ratio is kept below 3 dB for efficient polarization converting activity. Correspondingly, axial ratio bandwidth of 800 MHz is obtained. The proposed MS can easily be fabricated and integrated into many desired applications by proper configurations depending on the application area and frequencies. The proposed MS has potential such as polarization converter with 0.75 efficiency in WiMAX frequency band, PMC-like treatment with a phase reflection around 0[Formula: see text] and reflection coefficient nearly unity at some frequency points. Beside this, the three nested rectangle MSs also provide opportunities to design low profile antennas with conversion characteristics.
Low-resource Multi-task Audio Sensing for Mobile and Embedded Devices via Shared Deep Neural Network Representations
Authors: Georgiev Petko , Bhattacharya Sourav , Lane Nicholas D. , Mascolo Cecilia 
Published: September 2017

Continuous audio analysis from embedded and mobile devices is an increasingly important application domain. More and more, appliances like the Amazon Echo, along with smartphones and watches, and even research prototypes seek to perform multiple discriminative tasks simultaneously from ambient audio; for example, monitoring background sound classes (e.g., music or conversation), recognizing certain keywords (‘Hey Siri' or ‘Alexa'), or identifying the user and her emotion from speech. The use of deep learning algorithms typically provides state-of-the-art model performances for such general audio tasks. However, the large computational demands of deep learning models are at odds with the limited processing, energy and memory resources of mobile, embedded and IoT devices.
In this paper, we propose and evaluate a novel deep learning modeling and optimization framework that specifically targets this category of embedded audio sensing tasks. Although the supported tasks are simpler than the task of speech recognition, this framework aims at maintaining accuracies in predictions while minimizing the overall processor resource footprint. The proposed model is grounded in multi-task learning principles to train shared deep layers and exploits, as input layer, only statistical summaries of audio filter banks to further lower computations.
We find that for embedded audio sensing tasks our framework is able to maintain similar accuracies, which are observed in comparable deep architectures that use single-task learning and typically more complex input layers. Most importantly, on an average, this approach provides almost a 2.1× reduction in runtime, energy, and memory for four separate audio sensing tasks, assuming a variety of task combinations.
Risk of falling in a stroke unit after acute stroke: The Fall Study of Gothenburg (FallsGOT)
Authors: Persson Carina U , Kjellberg Sigvar , Lernfelt Bodil , Westerlind Ellen , Cruce Malin , Hansson Per-Olof 
Published: September 2017

Objective: This study aimed to investigate incidence of falls and different baseline variables and their association with falling during hospitalization in a stroke unit among patients with acute stroke. Design: Prospective observational study. Setting: A stroke unit at a university hospital. Subjects: A consecutive sample of stroke patients, out of which 504 were included, while 101 declined participation. Methods: The patients were assessed a mean of 1.7 days after admission and 3.8 days after stroke onset. Main measures: The primary end-point was any fall, from admission to the stroke unit to discharge. Factors associated with falling were analysed using univariable and multivariable Cox hazard regression analyses. Independent variables were related to function, activity and participation, as well as personal and environmental factors. Results: In total, 65 patients (13%) fell at least once. Factors statistically significantly associated with falling in the multivariable analysis were male sex (hazard ratio (HR): 1.88, 95% confidence interval (CI): 1.13–3.14, P = 0.015), use of a walking aid (HR: 2.11, 95% CI: 1.24–3.60, P = 0.006) and postural control as assessed with the modified version of the Postural Assessment Scale for Stroke Patients (SwePASS). No association was found with age, cognition or stroke severity, the HR for low SwePASS scores (⩽24) was 9.33 (95% CI: 2.19–39.78, P = 0.003) and for medium SwePASS scores (25–30) was 6.34 (95% CI: 1.46–27.51, P = 0.014), compared with high SwePASS scores (⩾31). Conclusion: Postural control, male sex and use of a walking aid are associated with falling during hospitalization after acute stroke.
Merger of Public Sector Banks in India Under the Rule of Reason
Authors: Ladha Rani S. 
Published: September 2017

This article models the idea of rule of reason of the antitrust literature and applies the model to analyse the possible consolidation of the Indian banking industry through merger and acquisition activities. It offers a strategic perspective for public sector banks whereby the banks either meet societal goals or become savvy international players through mergers. India being an emerging economy, the banking industry faces two critical initiatives: (i) proactive servicing of the rural areas and priority sectors and (ii) a serious presence in the international markets to compete with larger global banks. The model developed in this article suggests ways to evaluate and examine mergers in the banking sector in India to support both these initiatives. It proposes that the government could use the threat of merger to induce reluctant public sector banks to meet the critical domestic agenda and performance metrics. Those that meet the societal goals may continue to have the benefit of the status quo. Those that do not are required to merge to form an entity that can internationally compete in raising equity and deposits and providing loans and services. JEL Classification: G34, G38, K21
A randomized, placebo-controlled study of the cardiovascular safety of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus
Authors: Gantz Ira , Chen Menghui , Suryawanshi Shailaja , Ntabadde Catherine , Shah Sukrut , O’Neill Edward A. , Engel Samuel S. , Kaufman Keith D. , Lai Eseng 
Published: September 2017

Abstract
Background
Omarigliptin is a once-weekly (q.w.) oral DPP-4 inhibitor that is approved for the treatment of patients with type 2 diabetes mellitus (T2DM) in Japan. To support approval of omarigliptin in the United States, the clinical development program included a cardiovascular (CV) safety study. Subsequently, a business decision was made not to submit a marketing application for omarigliptin in the United States, and the CV safety study was terminated. Herein we report an analysis of data from that early-terminated study.

Methods
In this randomized, double-blind study, 4202 patients with T2DM and established CV disease were assigned to either omarigliptin 25 mg q.w. or matching placebo in addition to their existing diabetes therapy. A Cox proportional hazards model was used to summarize the primary endpoint of time to first major adverse CV event (MACE, the composite of CV death, nonfatal myocardial infarction, and nonfatal stroke) and the analysis of first event of hospitalization for heart failure (hHF).

Results
The median follow-up was approximately 96 weeks (range 1.1–178.6 weeks). The primary MACE outcome occurred in 114/2092 patients in the omarigliptin group (5.45%; 2.96/100 patient-years) and 114/2100 patients in the placebo group (5.43%; 2.97/100 patient-years), with a hazard ratio (HR) of 1.00 (95% confidence interval [CI] 0.77, 1.29). The hHF outcome occurred in 20/2092 patients in the omarigliptin group (0.96%; 0.51/100 patient-years) and 33/2100 patients in the placebo group (1.57%; 0.85/100 patient-years), with an HR of 0.60 (95% CI 0.35, 1.05). After 142 weeks, the least-squares mean difference (omarigliptin vs. placebo) in glycated hemoglobin levels was −0.3% (95% CI −0.46, −0.14). The numbers of patients with adverse events, serious adverse events or discontinued from study medication due to adverse events were similar in the omarigliptin and placebo groups.

Conclusions
In this CV safety study of patients with T2DM and established CV disease, omarigliptin did not increase the risk of MACE or hHF and was generally well tolerated.
Trial registration ClinicalTrials.gov: NCT01703208. Registered 05 October 2012
Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells
Authors: Xu Zihang , Zhang Fei , Bai Chao , Yao Chao , Zhong Hairong , Zou Chunpu , Chen Xiao 
Published: September 2017

Abstract
Background
Pancreatic cancer is generally acknowledged as the most common primary malignant tumor, and it is known to be resistant to conventional chemotherapy. Novel, selective antitumor agents are pressingly needed.

Methods
CCK-8 and colony formation assay were used to investigate the cell growth. Flow cytometry analysis was used to evaluate the cell cycle and cell apoptosis. The peroxide-sensitive fluorescent probe DCFH-DA was used to measure the intracellular ROS levels. Western blot assay was used to detect the levels of cell cycle and apoptosis related proteins. Xenografts in nude mice were used to evaluate the effect of Sophoridine on pancreatic cancer cell in vivo.

Results
Sophoridine killed cancer cells but had low cytotoxicity to normal cells. Pancreatic cancer cells were particularly sensitive. Sophoridine inhibited the proliferation of pancreatic cancer cells and induced cell cycle arrest at S phase and mitochondrial-related apoptosis. Moreover, Sophoridine induced a sustained activation of the phosphorylation of ERK and JNK. In addition, Sophoridine provoked the generation of reactive oxygen species (ROS) in pancreatic cancer cells. Finally, in vivo, Sophoridine suppressed tumor growth in mouse xenograft models.

Conclusion
These findings suggest Sophoridine is promising to be a novel, potent and selective antitumor drug candidate for pancreatic cancer.
Treatment of depression in schizophrenia: Systematic review and meta-analysis
Authors: Gregory Angharad , Mallikarjun Pavan , Upthegrove Rachel 
Published: September 2017

BackgroundDepression in schizophrenia predicts poor outcomes, including suicide, yet the effectiveness of antidepressants for its treatment remains uncertain.AimsTo synthesise the evidence of the effectiveness of antidepressants for the treatment of depression in schizophrenia.MethodMultiple databases Were searched and inclusion Criteria included participants aged over 18 years with schizophrenia or related psychosis with a depressive episode. Papers were quality assessed used the Cochrane risk bias tool. Meta-analyses were performed for risk difference and standardised mean difference of all antidepressants, antidepressant class and individual antidepressant where sufficient studies allowed.ResultsA total of 26 moderate- to low-quality trials met inclusion criteria. In meta-analysis a significant risk difference was found in favour of antidepressant treatment, with a number needed to treat of 5 (95% CI 4–9). Studies using tools specifically designed to assess depression in schizophrenia showed a larger effect size. However, after sensitivity analysis standardised mean difference of all antidepressants did not show a statistically significant improvement in depression score at end-point, neither did any individual antidepressant class.ConclusionsAntidepressants may be effective for the treatment of depression in schizophrenia, however, the evidence is mixed and conclusions must be qualified by the small number of low- or moderate-quality studies. Further sufficiently powered, high-quality studies are needed.
Characterization of Pulmonary Metastases in Children With Hepatoblastoma Treated on Children’s Oncology Group Protocol AHEP0731 (The Treatment of Children With All Stages of Hepatoblastoma): A Report From the Children’s Oncology Group
Authors: O’Neill Allison F. , Towbin Alexander J. , Krailo Mark D. , Xia Caihong , Gao Yun , McCarville M. Beth , Meyers Rebecka L. , McGahren Eugene D. , Tiao Greg M. , Dunn Stephen P. , Langham Max R. , Weldon Christopher B. , Finegold Milton J. , Ranganathan Sarangarajan , Furman Wayne L. , Malogolowkin Marcio , Rodriguez-Galindo Carlos , Katzenstein Howard M. 
Published: September 2017

Purpose To determine whether the pattern of lung nodules in children with metastatic hepatoblastoma (HB) correlates with outcome. Methods Thirty-two patients with metastatic HB were enrolled on Children’s Oncology Group Protocol AHEP0731 and treated with vincristine and irinotecan (VI). Responders to VI received two additional cycles of VI intermixed with six cycles of cisplatin/fluorouracil/vincristine/doxorubicin (C5VD), and nonresponders received six cycles of C5VD alone. Patients were imaged after every two cycles and at the conclusion of therapy. All computed tomography scans and pathology reports were centrally reviewed, and information was collected regarding lung nodule number, size, laterality, timing of resolution, and pulmonary surgery. Results Among the 29 evaluable patients, only 31% met Response Evaluation Criteria in Solid Tumors (RECIST) for measurable metastatic disease. The presence of measurable disease by RECIST, the sum of nodule diameters greater than or equal to the cumulative cohort median size, bilateral disease, and ≥ 10 nodules were each associated with an increased risk for an event-free survival event ( P = .48, P = .08, P = .065, P = .03, respectively), with nodule number meeting statistical significance. Ten patients underwent pulmonary resection/metastasectomy at various time points, the benefit of which could not be determined because of small patient numbers. Conclusion Children with metastatic HB have a poor prognosis. Overall tumor burden may be an important prognostic factor for these patients. Lesions that fail to meet RECIST size criteria (ie, those < 10 mm) at diagnosis may contain viable tumor, whereas residual lesions at the end of therapy may constitute eradicated tumor/scar tissue. Patients may benefit from risk stratification on the basis of the burden of lung metastatic disease at diagnosis.
A support worker's guide to models of living and nursing
Authors: Stonehouse David 
Published: September 2017

As a follow-up to the author's recent thoughts on ‘understanding the nursing process’ ( Stonehouse, 2017 ), this article examines the two complementary models of Roper, Logan and Tierney (1980) : their model of living and model of nursing. The different components which make up the two models will be explored and related to clinical practice. It is important for support workers to understand both models and how they are being used within their clinical environment. Through support workers examining different models will assist in achieving section 6 of The Code of Conduct for Healthcare Support Workers and Adult Social Care Workers in England ( Skills for Care and Skills for Health, 2013 ), which urges employees to ‘strive to improve the quality of healthcare, care and support through continuing professional development’.
Functional and morphological imaging of the human tympanic membrane with endoscopic optical coherence tomography
Authors: Kirsten Lars , Morgenstern Joseph , Erkkilä Mikael Timo , Schindler Martin , Golde Jonas , Walther Julia , Kemper Max , Stoppe Thomas , Bornitz Matthias , Neudert Marcus , Zahnert Thomas , Koch Edmund 
Published: September 2017

Abstract
In this ex vivo feasibility study, endoscopic structural and functional optical coherence tomography (OCT) imaging with a field of view of 8 mm is presented allowing the inspection of nearly the entire tympanic membrane through the ear canal. The endoscope utilizes a gradient index optics for simultaneous OCT and video endoscopy. Additionally, Doppler-OCT allows the measurement of the tympanic membrane oscillation. Due to the fast image acquisition, only minor motion artifacts have been observed, which don’t affect the image quality. In conclusion, endoscopic OCT is considered as a promising tool for the comprehensive examination of the human middle ear.
Evaluation and image quality comparison of ultra-thin fibre endoscopes for vascular endoscopy
Authors: Boese Axel , Sivankutty Akhil Karthasseril , Friebe Michael 
Published: September 2017

Abstract
Medical applications like vascular endoscopy can provide additional diagnostic value for future procedures [1]. For these applications an optimal compromise between image quality and fibre flexibility has to be identified. Image quality of endoscopes is normally estimated using flat test objects or charts. For the application of vascular endoscopy a tubular test set up seems to be more beneficial. We compare three fibre endoscopes with different diameters and number of integrated fibre according to image quality and flexibility. Based on the results a recommendation for possible applications in vascular endoscopy is given.
Numerical simulation of pulsatile flow through a coronary nozzle model based on FDA’s benchmark geometry
Authors: Stiehm Michael , Wüstenhagen Carolin , Siewert Stefan , Grabow Niels , Schmitz Klaus-Peter 
Published: September 2017

Abstract
Computational fluid dynamics (CFD) is a powerful tool to extent knowledge of biomechanical processes in cardiovascular implants.
To provide a standardized method the U.S. Food and Drug Administration (FDA) initialized a CFD round robin study. One of the developed benchmark standard models is a generic nozzle geometry, consisting of a cylindrical throat with a conical collector and sudden expansion on either side. Several fluid mechanical data obtained from international institutes by means of CFD and particle image velocimetry (PIV) measurements under different flow regimes (Re = 500, 2000, 3500, 5000 and 6500) are freely available.
This database includes only steady state simulations. In this study we performed pulsatile CFD simulations to consider the physiological environment of the coronary vessels. Furthermore, the nozzle geometry was scaled down to coronary dimension (D
inlet
= 12 mm to 3 mm) while retaining the average Reynolds number Re = 500 constant. The pulsatile character is described by a Womersley number of Wo = 2.065. Our CFD code was previously validated by using FDA’s data for steady state inflow conditions.
It could be shown that time averaged wall shear stress and shear stress values agree well with steady state results. We conclude that steady state simulations are valid for hemodynamic analyses if only time averaged values are needed. This could save computational costs of future hemodynamic investigations.
In addition, this study expands FDA’s benchmark case by pulsatile inlet condition for further code validation. This could be necessary for the development of new numerical methods as well as for validation of CFD codes used in the approval process of medical devices.
Innovation and Internationalization: Relationship and Implications for Management and Public Policy
Authors: Freixanet Joan 
Published: September 2017

ABSTRACT
Innovation and internationalization are two basic growth strategies which contend for both the firms’ and governments resources. At the same time, they are linked by a two-way relationship that has been widely documented in previous studies. However, often preceding literature is disconnected and does not integrate innovation and export promotion studies into the analysis. In this article we review and synthesize the different approaches regarding these relationships, while considering also the research on the impact of export promotion programs. As a result, a list of recommendations is deduced both for management and public policy regarding the development of these two strategies.
Binary Options as a Modern Fenomenon of Financial Business
Authors: Kolková Andrea , Lenertová Lucie 
Published: September 2017

Abstract
Binary options are a new instrument of the financial market. The aim of this paper is to analyze the use of binary options with trading and to illustrate this on the practical example of trades based on Bollinger bands indicator. Currency pair EUR/USD and 6912 time series values of this instrument will be put to analysis. The contribution will be evaluated 8 strategies based on Bollinger Bands. There will be used a backtesting method. From the results follows the most trades could have been realized with the use of Bollinger bands with a double deviation. This strategy, however, also showed the greatest percentage of failed trades. On the contrary the fewest transactions could have been carried out with Bollinger bands with a triple deviation and the MACD filter.