bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of a culturally adapted technology-delivered, family-based childhood obesity intervention for Latino/Hispanic families in rural Nebraska: the Hispanic Family Connections study protocol
Authors: Brito Fabiana Almeida , Alves Thais Favero , Santos Natalia , Michaud Tzeyu L , Eisenhauer Christine , De Leon Elisa Brosina , Squarcini Camila Fabiana Rossi , Kachman Stephen , Almeida Fabio , Estabrooks Paul 
Published: October 2024

IntroductionAddressing childhood obesity risk factors like home environment, parental roles, excess weight, physical activity and healthy eating among Latino/Hispanic (L/H) families living in rural communities is an important priority. However, evidence supporting these interventions among L/H families living in rural communities is missing. Our trial will use cultural adaptation and implementation science frameworks to evaluate the feasibility of delivering a culturally appropriate family-based childhood obesity (FBCO) programme via an automated telephone system (interactive voice response) to L/H families in rural Nebraska.Methods and analysisA mixed-methods feasibility trial for L/H families with overweight or obese children. Aim 1 will focus on collaboratively adapting and evaluating all intervention materials to fit the rural L/H community profile better, including translation of materials to Spanish, culturally relevant content and images, and use of health communication strategies to address different levels of health literacy. In aim 2, a 6-month feasibility trial with contextual evaluation will randomise 48 dyads (parent and child) to either Family Connections (FC; n=29) or a waitlist standard-care group (n=29) to determine overall study reach, preliminary effectiveness in reducing child body mass index (BMI) z-scores, potential for programme adoption, implementation and sustainability through local health departments (RE-AIM outcomes). We will also evaluate health department perceptions of the integrated-Promoting Action on Research Implementation in Health Services (i-PARIHS) constructs (innovation, context, recipient characteristics) and FC participants’ view of the intervention (ie, relative advantage, observability, trialability, complexity, compatibility). The study will answer three critical questions: (1) is a telephone-delivered FBCO programme in rural Nebraska culturally relevant, usable and acceptable by L/H families?; (2) is a telephone-delivered FBCO programme effective at reducing BMI z-scores in L/H children living in rural Nebraska? and (3) what real-world institutional and contextual factors influence the impact of the intervention and might affect its potential ability to sustainably engage a meaningful population of L/H families who stand to benefit?Ethics and disseminationThis protocol was approved by the University of Nebraska Medical Center Institutional Review Board (IRB#:0745-20-EP). Dissemination of findings will occur through ClinicalTrials.gov, in scientific forums and to the local rural communities, pilot data to inform the design of a larger clinical trial.Trial registration numberNCT04731506.
Association between ethnicity and emergency department visits in the last three months of life in England: a retrospective population-based study using electronic health records
Authors: Davies Joanna M , Leniz Javiera , Chua Kia-Chong , Williamson Lesley E , Bajwah Sabrina , Bolton Thomas , Bone Anna E , Hocaoglu Mevhibe , Verne Julia , Fraser Lorna K , Barclay Stephen , Murtagh Fliss E M , Higginson Irene J , Sleeman Katherine E 
Published: October 2024

IntroductionEmergency department (ED) visits are distressing yet common in the last months of life and many could be avoided. The association between ethnicity and ED visits in the last months of life has rarely been studied in detail and the intersection with area-based deprivation and other risk factors is not known.MethodsPopulation-based, retrospective cohort study, using electronic health records for adults who died from all causes in 2019 and 2020 in England.ResultsOf 566 930 deaths in 2020, 356 700 (62.9%) had at least one ED visit in the last 3 months of life. Most ethnic minority groups had more ED visits than white British people and differences were larger for visits out-of-hours. After adjusting for social and clinical factors, compared with white British people, the out-of-hours visit rate for people with Bangladeshi, Pakistani and Indian ethnicities was 17% (95% CI 6% to 28%), 19% (95% CI 12% to 27%) and 14% (95% CI 6% to 22%) higher for women, and 16% (95% CI 9% to 23%), 13% (95% CI 8% to 19%) and 6% (95% CI 0% to 12%) higher for men. The rate of visits was lower in 2020 than in 2019, but differences between ethnic groups were similar. For white British people, there is a clear social gradient—those who live in more deprived areas have a higher rate of ED visits—but this is not seen for most other ethnic groups.ConclusionPeople with Bangladeshi, Indian and Pakistani ethnicities have higher rates of ED visits in the last 3 months of life that are not fully explained by other social and clinical factors. This difference is driven by visits out-of-hours, which may indicate a need for better support. Future work should try to understand why some ethnic minority groups use ED more and how this relates to differences in needs, preferences and experiences.
Transumbilical access for neonatal vein of Galen malformation and pial arteriovenous fistula embolization
Authors: Bazil Maximilian Jeremy , Fifi Johanna T , Berenstein Alejandro , Shigematsu Tomoyoshi 
Published: October 2024

BackgroundIn the neonatal period, transfemoral access may be complicated by sheath size needed for embolization, especially if retreatment is required. A viable alternative is access through an umbilical artery (UA) which allows for preservation of the femoral artery for access in future intervention.MethodsWe conducted a retrospective study from January 2014 to March 2023, focusing on 19 vein of Galen malformation, dural arteriovenous (AV) fistula, and pial AV fistula cases treated via transumbilical (TU) access for endovascular embolization in neonates.ResultsTU access was achieved successfully in 20 out of 21 intended cases, with a 4 French sheath placed intraprocedurally in all instances. We observed a median retreatment time of 7 months for patients requiring subsequent femoral artery access, highlighting the importance of preserving femoral access for future interventions. There were no complications associated with TU access or sheath retention and no procedural mortality attributed to this approach. Despite intraprocedural and periprocedural complications of other etiologies (including post-procedural hemorrhages and fever requiring antibiotic treatment), the TU approach demonstrated overall safety and efficacy.ConclusionsOur findings align with previous reports of TU access in vascular malformations, emphasizing its role as a vital technique in neonatal neurointervention. The TU approach offers advantages such as sparing femoral arteries for future treatments and potential applicability to other high-flow brain fistulas. Our study contributes to the growing body of evidence supporting the use of TU access in neonatal neuroendovascular interventions, underscoring its importance in managing complex vascular malformations in this vulnerable population.
Efficacy and safety of CT-P47 versus reference tocilizumab: 32-week results of a randomised, active-controlled, double-blind, phase III study in patients with rheumatoid arthritis, including 8 weeks of switching data from reference tocilizumab to CT-P47
Authors: Smolen Josef S , Trefler Jakub , Racewicz Artur , Jaworski Janusz , Zielińska Agnieszka , Krogulec Marek , Jeka Sławomir , Wojciechowski Rafał , Kolossa Katarzyna , Dudek Anna , Krajewska-Włodarczyk Magdalena , Hrycaj Paweł , Klimiuk Piotr Adrian , Burmester Gerd R , Kim SungHyun , Bae YunJu , Yang GoEun , Jung YooBin , Hong JiWoo , Keystone Edward 
Published: October 2024

ObjectivesTo demonstrate efficacy equivalence of CT-P47 and EU-approved reference tocilizumab (r-TCZ) in patients with rheumatoid arthritis (RA).MethodsThis double-blind, phase III study randomised (1:1) patients to receive CT-P47 or r-TCZ (8 mg/kg) every 4 weeks until week 20 during treatment period (TP) 1. Prior to week 24 dosing, patients receiving r-TCZ were randomised (1:1) to continue r-TCZ or switch to CT-P47; patients receiving CT-P47 continued CT-P47 (TP2, 8 mg/kg every 4 weeks until week 48). The dual primary endpoints (for different regulatory requirements) were mean changes from baseline in Disease Activity Score in 28 joints (DAS28; erythrocyte sedimentation rate (ESR)) at week 12 and week 24. Efficacy equivalence was determined if CIs for the treatment difference were within predefined equivalence margins: (95% CI −0.6, 0.6 (analysis of covariance (ANCOVA)) at week 12 or 90% CI −0.6, 0.5 (ANCOVA with multiple imputation) at week 24). Additional efficacy, pharmacokinetic (PK) and safety endpoints, including immunogenicity, were investigated. Findings up to week 32 are presented.ResultsIn TP1, 471 patients were randomised (234 CT-P47; 237 r-TCZ). The 95% and 90% CIs for the estimated treatment differences were contained within the predefined equivalence margins; the estimated difference in DAS28-ESR at week 12 was –0.01 (95% CI −0.26, 0.24) and at week 24 was −0.10 (90% CI −0.30, 0.10). Secondary efficacy endpoints, PKs and overall safety were comparable between groups up to week 32.ConclusionsEfficacy equivalence, alongside comparable PK, safety and immunogenicity profiles, was determined between CT-P47 and r-TCZ in adults with RA, including after switching from r-TCZ to CT-P47.
Comorbidity burden on mortality in patients with systemic sclerosis
Authors: Fauthoux Thomas , Brisou Damien , Lazaro Estibaliz , Seneschal Julien , Constans Joel , Skopinski Sophie , Duffau Pierre , Blanchard Elodie , Contin-Bordes Cécile , Barnetche Thomas , Truchetet Marie-Elise 
Published: October 2024

IntroductionSystemic sclerosis (SSc) is a serious life-threatening tissue disease. A significant aspect of its mortality arises from comorbid conditions. Our study aimed at mapping out the prevalence of these comorbidities and their relation to mortality, thus creating a ‘comorbidome’.MethodsIn our retrospective, single-centre observational study, we recorded each patient’s data, including demographic informations, vital stats and SSc-related organ involvement, along with the presence or absence of 14 predefined comorbidities. We also documented the dates of their initial and most recent visits. To construct survival curves, we used the Kaplan-Meier method, followed by a Cox regression model for multivariate analysis.ResultsOur study involved 400 participants, 74 of whom unfortunately passed away. It is important to note that three specific comorbidities showed significant correlation to mortality: neoplasia, cardiovascular diseases and polypharmacy, as well as two SSc-specific organ involvements (lung and cardiac).ConclusionOur research led to the successful creation of the SSc comorbidome. Comorbidities are a major concern for patients suffering from SSc, particularly cardiovascular diseases and neoplasms. Our study highlights the effects of polypharmacy. The resultant comorbidome offers a comprehensive and analytical perspective on this complex issue and underscores the inter-relatedness of the data. Our study, however, was limited by a small sample size. Therefore, to confirm our findings, validation on a larger scale is necessary. This could potentially contribute to the creation of a future mortality scoring tool.
Response of soil nitrogen mineralization, nitrification, and denitrification to milk vetch (Astragalus sinicus L.) application in a paddy field
Authors: Wang Limin , He Chunmei , Liu Cailing , Zheng Xiangzhou , Yu Juhua , Li Qinghua , Huang Yibin , Huang Dongfeng , Wang Fei 
Published: October 2024

We conducted incubation experiments with paddy soil collected from a long-term field experiment to explore the effect of Chinese milk vetch ( Astragalus sinicus L., CMV) application on potential nitrogen (N) denitrification (PDA), nitrification (PNA), mineralization (PNM), soil chemical properties, microbial communities, enzyme activities, yields, and nutrient uptake of rice under different fertilization treatments. Five treatments were included: no chemical fertilizers (C0), chemical fertilizers (C100), Chinese milk vetch (M), CMV combined with 100% chemical fertilizers (MC100), and with 80% chemical fertilizers (MC80). Results showed that the M, MC100, and MC80 treatments significantly increased PNM and PNA compared with the C100 treatment ( P < 0.05). Meanwhile, the CMV application significantly increased total N, microbial biomass N, and carbon (C) concentrations, the abundances of the bacterial phylum Actinobacteria and the genera Bradyrhizobium, Mycobacterium, Streptomyces, and Reyranella, N-acetyl-glucosaminidase (NAG) activity, yields, and N nutrient uptake of rice grain compared with the C100 treatment ( P < 0.05). Correlation analyses indicated that grain yield and N uptake of rice, soil total N, microbial biomass C and N, the bacterial phylum Actinobacteria, the genera Bradyrhizobium, Mycobacterium, Streptomyces, Reyranella, and NAG were significantly correlated with PNM under different fertilization regimes, while microbial biomass C and N, Actinobacteria, Bradyrhizobium, and Reyranella were positively related to PNA ( P < 0.05). Together, the application of CMV alone or in combination with chemical fertilizers can improve soil properties and rice growth, which may accelerate N mineralization and nitrification in this soil.
Preserving quantum information in f(Q) non-metric gravity cosmology
Authors: Capozziello Salvatore , Lapponi Alessio , Luongo Orlando , Mancini Stefano 
Published: October 2024

AbstractThe effects of cosmological expansion on quantum bosonic states are investigated, using quantum information theory. In particular, a generic Bogoliubov transformation of bosonic field modes is considered and the state change on a single mode is regarded as the effect of a quantum channel. Properties and capacities of this channel are thus explored in the framework of f(Q) non-metric gravity. The reason is that non-metric gravity can be considered under the standard of gauge theories with all the advantages of such a formulation. As immediate result, we obtain that the information on a single-mode state appears better preserved, whenever the number of particles produced by the cosmological expansion is small. Specifically, we investigate a power law f(Q) model, leaving unaltered the effective gravitational coupling, and minimise the corresponding particle production. We thus show how to optimise the preservation of classical and quantum information, stored in bosonic mode states in the remote past. Finally, we compare our findings with those obtained in General Relativity.
FRACTAL FEATURE MODELING: MULTI-DIMENSIONAL ATTENTION AND SPATIAL ADAPTIVE RELATIONSHIP LEARNING FOR PERSON RE-IDENTIFICATION
Authors: XIONG MINGFU , CHEN HANMEI , KARACA YELIZ , SAUDAGAR ABDUL KHADER JILANI , LEE IK HYUN , SER JAVIER DEL , MUHAMMAD KHAN 
Published: October 2024

Person Re-identification (person Re-ID), as an intelligent video surveillance technology capable of retrieving the same person from different cameras, may bring about some challenges arising from the changes in the person’s poses, different camera views as well as occlusion. Recently, person Re-ID equipped with the attention mechanism has gradually emerged as one of the most active areas of study in the fields of computer vision and fractal feature modeling applications. Despite the upsurge in related research, existing fractal-attention-based methods still face two major challenges when recognizing different pedestrians in unpredictable realistic environments: (1) the adaptability of a single local attention feature to hostile scenes cannot be guaranteed, and (2) the existing methods originating from attention features usually rely on the line mapping or simple variants, which make it difficult to excavate the association relationships among pedestrians with similar appearance attributes. To address these issues, this paper proposes a simple effective fractal feature modeling method, named multi-dimensional attention and spatial adaptive relationship learning framework (MASARF) to explore the correlation between pedestrian bodies for person Re-ID. The proposed framework encompasses a multi-dimensional fractal-attention feature learning model (MDAM) and a dual-branch graph convolutional model (DGCM). In particular, the MDAM comprises the local and global attention modules, which are used to capture multi-dimensional attention features for each person. Subsequently, the DGCM is used to construct the nonlinear mapping association relationships among the various body regions for each person via a dual-branch graph convolutional optimization strategy. Extensive experiments were conducted using public person Re-ID datasets (Market-1501, DukeMTMC-reid, and CUHK-03). The results demonstrate that the performance of the proposed approach is superior to that of state-of-the-art methods between 2% and 10% at Rank-1 (mAP). Essential differences exist between our method and the existing methods in terms of feature extraction and relationship transformation, which provides the validation of its novelty in the person Re-ID domain.
Exploring the Consequences of Aggressive Experiences on Psychiatric Nurses: A Real‐Time Assessment Study
Authors: Weltens Irene , Drukker Marjan , Amelsvoort Thérèse van , Domen Patrick , Bak Maarten 
Published: October 2024

Aims: Aggression on psychiatric wards is a complex issue with significant consequences for both patients and healthcare providers. This study aimed to investigate the behavioural and emotional consequences of aggressive experiences on nurses working in psychiatric wards both at work and at home as well as the contribution of nurses’ behaviour to the development of aggression.Methods: This research utilised the experience sampling method (ESM) to collect real‐time data from nurses working in a high intensive care (HIC) unit within a mental health institution in the Netherlands.Results: The findings revealed that most nurses reported good sleep quality, feeling fit for the day and looking forward to starting their day. These reports were not significantly associated with having a workday ahead or the number of patients admitted. There was a negative association with the number of admitted patients being on or over the maximum bed capacity, although not significant.There were no statistically significant associations between the answers to the morning questionnaire and the behaviour and emotions of nurses and patients later that day nor the appearance of aggressive incidents. Experiencing an aggressive incident had no influence on the sleep of the nurse later that day, nor on their social behaviour.Conclusion: This study offers valuable insights into the daily experiences of nurses in psychiatric wards, particularly in relation to aggression. The real‐time data collection by ESM allowed for a nuanced understanding of nurses’ behaviours and emotions. No significant associations were found between nurses’ functioning and aggressive incidents happening on the ward, but this study might have been contextually influenced so that this study mainly highlights the need for further research with larger samples and across multiple wards to draw definitive conclusions.
Abstract A045: PSB120, a LILRB2 specific antibody enhances sensitivity to Gemcitabine through an HLA-G independent mechanism
Authors: Peng YuFeng , Munir Annum , Zhang Meijuan 
Published: October 2024

Abstract
The suppressive micro-environment within tumors is partly caused by infiltrating macrophages. Expression of HLA-G on tumor cells and its receptor LILRB2 on tumor macrophages are associated with poor prognosis in cancer patients. Anti LILRB2 antibodies have been developed to block HLA-G and LILRB2 interaction and to promote M1 macrophage differentiation. Whether anti LILRB2 antibody can exert its effect through an HLA-G independent mechanism has not been investigated. Here, we describe PSB120, a fully humanized anti LILRB2 antibody with high affinity to LILRB2 without cross-reactivity to other members of LILR family. PSB120 blocks HLA-G binding with high efficiency. In vitro, PSB120 changes macrophage differentiation by significantly enhancing M1 phenotypes and down-regulating several M2 phenotypes, including enhanced TNF production, down-regulation of CD163 and CD14, and reduced capability of efferocytosis. Interestingly, these activities were observed in both HLA-G blockers and non-blockers, suggesting an HLA-G independent mechanism. We further determined the in vivo efficacy of PSB120 in LILRB2-B3 transgenic mice using syngeneic tumor models. We found PSB120 can be combined with anti-mPD1 to synergistically inhibit the growth of wild type MC38 tumor cells. The synergistic effect of PSB120 is inversely correlated with its Fc receptor binding activity: antibody without FcR binding showed significant activity, whereas those with IgG4 Fc or enhanced Fc binding showed no activity. Furthermore, PSB120 can significantly enhance the activity of Gemcitabine in both MC38 and LLC tumor models in LILRB2-B3 transgenic mice. Since neither MC38 nor LLC tumor cells express HLA-G, these results demonstrated the HLA-G independent mechanism of PSB120. In summary, these findings uncovered an HLA-G independent function of anti LILRB2 antibodies and suggested the potential to broaden their applications in immunotherapy.
Citation Format: YuFeng Peng, Annum Munir, Meijuan Zhang. PSB120, a LILRB2 specific antibody enhances sensitivity to Gemcitabine through an HLA-G independent mechanism [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2024 Oct 18-21; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2024;12(10 Suppl):Abstract nr A045.