bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2− Metastatic Breast Cancer
Authors: Mayer Ingrid A. , Abramson Vandana G. , Formisano Luigi , Balko Justin M. , Estrada Mónica V. , Sanders Melinda E. , Juric Dejan , Solit David , Berger Michael F. , Won Helen H. , Li Yisheng , Cantley Lewis C. , Winer Eric , Arteaga Carlos L. 
Published: April 2016

AbstractPurpose: Alpelisib, a selective oral inhibitor of the class I PI3K catalytic subunit p110α, has shown synergistic antitumor activity with endocrine therapy against ER+/PIK3CA-mutated breast cancer cells. This phase Ib study evaluated alpelisib plus letrozole's safety, tolerability, and preliminary activity in patients with metastatic ER+ breast cancer refractory to endocrine therapy.Experimental Design: Twenty-six patients received letrozole and alpelisib daily. Outcomes were assessed by standard solid-tumor phase I methods. Tumor blocks were collected for DNA extraction and next-generation sequencing.Results: Alpelisib's maximum-tolerated dose (MTD) in combination with letrozole was 300 mg/d. Common drug-related adverse events included hyperglycemia, nausea, fatigue, diarrhea, and rash with dose-limiting toxicity occurring at 350 mg/d of alpelisib. The clinical benefit rate (lack of progression ≥6 months) was 35% (44% in patients with PIK3CA-mutated and 20% in PIK3CA wild-type tumors; 95% CI, 17%–56%), including five objective responses. Of eight patients remaining on treatment ≥12 months, six had tumors with a PIK3CA mutation. Among evaluable tumors, those with FGFR1/2 amplification and KRAS and TP53 mutations did not derive clinical benefit. Overexpression of FGFR1 in ER+/PIK3CA mutant breast cancer cells attenuated the response to alpelisib in vitro.Conclusions: The combination of letrozole and alpelisib was safe, with reversible toxicities. Clinical activity was observed independently of PIK3CA mutation status, although clinical benefit was seen in a higher proportion of patients with PIK3CA-mutated tumors. Phase II and III trials of alpelisib and endocrine therapy in patients with ER+ breast cancer are ongoing. Clin Cancer Res; 23(1); 26–34. ©2016 AACR.
Imprensa universitária no Brasil: a trajetória da Agência Universitária de Notícias (AUN) durante a ditadura militar e no novo período democrático
Authors: Silva André Chaves de Melo , Martins Leandra Rajczuk , Proença José Luiz 
Published: April 2016

Este artigo centra seu foco na trajetória histórica da Agência Universitária de Notícias (AUN). Pioneira no Brasil, esta mídia, vinculada à Universidade de São Paulo (USP), passou pelo período em que enfrentou interrupções em sua periodicidade – incluindo entre as causas pressões exercidas sobre sua atuação por agentes do Regime Militar Brasileiro (1964-1985) – e, depois, entrou, paulatinamente, em uma fase de estabilidade, vivida graças à redemocratização do País, passando do impresso para o digital e, recentemente, inaugurando seu novo site informativo (www.usp.br/aun)Palavras-chave: jornalismo; Agência Universitária de Notícias (AUN); democracia
Publicidade on-line: comunicação interativa
Authors: Gonzales Lucilene Dos Santos , Seridório Daniele Ferreira 
Published: April 2016

A publicidade na era digital reconfigurou-se; seus tradicionais paradigmas estão obsoletos, principalmente no que diz respeito à interação com seu público-alvo. Antes considerada uma comunicação em um só sentido, em que o fabricante e o anunciante se dirigem a um público que não podiam responder à comunicação emitida, agora o consumidor tem voz opina sobre a marca e é também co-produtor de marcas e produtos. As plataformas e estratégias dessa publicidade online interativa são objeto de reflexão deste artigo.
Apostolic Networks in the Third Wave of the Spirit
Authors: Bialecki Jon 
Published: April 2016

This essay discusses the relationship between the Vineyard and the various other apostolic networks. By comparing the Vineyard with C. Peter Wagner and the New Apostolic Revival, I contend that the chief difference between these two movements lies in a Vineyard interest in pedagogy over a New Apostolic Revival interest in governance, and in the Vineyard’s use of the figure of John Wimber as an exemplar for practice rather than as a figure of authority.
A Comparison of Antarctic Ice Sheet Surface Mass Balance from Atmospheric Climate Models and In Situ Observations
Authors: Wang Yetang , Ding Minghu , van Wessem J. M. , Schlosser E. , Altnau S. , van den Broeke Michiel R. , Lenaerts Jan T. M. , Thomas Elizabeth R. , Isaksson Elisabeth , Wang Jianhui , Sun Weijun 
Published: April 2016

Abstract
In this study, 3265 multiyear averaged in situ observations and 29 observational records at annual time scale are used to examine the performance of recent reanalysis and regional atmospheric climate model products [ERA-Interim, JRA-55, MERRA, the Polar version of MM5 (PMM5), RACMO2.1, and RACMO2.3] for their spatial and interannual variability of Antarctic surface mass balance (SMB), respectively. Simulated precipitation seasonality is also evaluated using three in situ observations and model intercomparison. All products qualitatively capture the macroscale spatial variability of observed SMB, but it is not possible to rank their relative performance because of the sparse observations at coastal regions with an elevation range from 200 to 1000 m. In terms of the absolute amount of observed snow accumulation in interior Antarctica, RACMO2.3 fits best, while the other models either underestimate (JRA-55, MERRA, ERA-Interim, and RACMO2.1) or overestimate (PMM5) the accumulation. Despite underestimated precipitation by the three reanalyses and RACMO2.1, this feature is clearly improved in JRA-55. However, because of changes in the observing system, especially the dramatically increased satellite observations for data assimilation, JRA-55 presents a marked jump in snow accumulation around 1979 and a large increase after the late 1990s. Although precipitation seasonality over the whole ice sheet is common for all products, ERA-Interim provides an unrealistic estimate of precipitation seasonality on the East Antarctic plateau, with high precipitation strongly peaking in summer. ERA-Interim shows a significant correlation with interannual variability of observed snow accumulation measurements at 28 of 29 locations, whereas fewer than 20 site observations significantly correlate with simulations by the other models. This suggests that ERA-Interim exhibits the highest performance of interannual variability in the observed precipitation.
Lymphoma development and survival in refractory coeliac disease type II: Histological response as prognostic factor
Authors: Nijeboer P , van Wanrooij RLJ , van Gils T , Wierdsma NJ , Tack GJ , Witte BI , Bontkes HJ , Visser O , Mulder CJJ , Bouma G 
Published: April 2016

BackgroundRefractory coeliac disease type II (RCDII) frequently transforms into an enteropathy‐associated T‐cell lymphoma (EATL) and therefore requires intensive treatment. Current evaluated treatment strategies for RCDII include cladribine (2‐CdA) and autologous stem cell transplantation (auSCT).ObjectiveThe purpose of this study was to evaluate long‐term survival and define clear prognostic criteria for EATL development comparing two treatment strategies.MethodsA total of 45 patients were retrospectively analysed. All patients received 2‐CdA, after which they were either closely monitored (monotherapy, n  = 30) or a step‐up approach was used including auSCT (step‐up therapy, n  = 15).ResultsTen patients (22%) ultimately developed EATL; nine of these had received monotherapy. Absence of histological remission after monotherapy was associated with EATL development (p  = 0.010). Overall, 20 patients (44%) died with a median survival of 84 months. Overall survival (OS) within the monotherapy group was significantly worse in those without histological remission compared to those with complete histological remission(p  = 0.030). The monotherapy group who achieved complete histological remission showed comparable EATL occurrence and OS as compared to the step‐up therapy group (p  = 0.80 and p  = 0.14 respectively).ConclusionHistological response is an accurate parameter to evaluate the effect of 2‐CdA therapy and this parameter should be leading in the decisions whether or not to perform a step‐up treatment approach in RCDII.
Coquandite, Sb6+xO8+x(SO4)(OH)x·(H2O)1–x (x = 0.3), from the Cetine mine, Tuscany, Italy: crystal structure and revision of the chemical formula
Authors: Bindi L. , Biagioni C. , Ceccantini L. , Batoni M. , Menchetti S. 
Published: April 2016

AbstractThe crystal structure of the mineral coquandite, a rare Sb oxy-sulfate hydrate, was solved using intensity data collected from a crystal from the Cetine mine, Tuscany, Italy. This study revealed that the structure is triclinic, space group P, with a = 11.4292(5), b = 29.772(1), c = 11.2989(5) Å, α = 91.152(3), β = 119.266(4), γ = 92.624(3)° and V = 3346.4(2) Å3. The refinement of an anisotropic model led to an R index of 0.0347 for 21,061 independent reflections. Thirty-two Sb sites, five S sites and 67 oxygen sites occur in the crystal structure of coquandite. Sb atoms display the characteristic SbO3E and SbO4E coordinations whereas S fills (SO4) tetrahedral groups. These atoms are arranged in five symmetry-independent layers perpendicular to b*. Four of them and their centrosymmetrical counterparts form complex modules stacked along b* and bonded through two Sb atoms and H bonds. The complex H bonding system in the structure is discussed. On the basis of information gained from this characterization, the crystal-chemical formula was revised according to the structural results, yielding Sb6+xO8+x(SO4)(OH)x·(H2O)1–x (Z = 10) with x = 0.3 instead of Sb6O8(SO4)·H2O (Z = 12) as reported previously. A recalculation of the chemical data listed in the scientific literature for coquandite according to the structural results obtained here leads to a satisfactory agreement.
The crystal structure of arangasite, Al2F(PO4)(SO4)·9H2O determined using low-temperature synchrotron data
Authors: Yakubovich O. V. , Steele I. M. , Chernyshev V. V. , Zayakina N. V. , Gamyanin G. N. , Karimova O. V. 
Published: April 2016

AbstractThe crystal structure of the fibrous mineral arangasite, Al2F(PO4)(SO4)·9H2O from the Alyaskitovoje deposit, Eastern Yakutiya, Russia, was solved using low-temperature single-crystal data from synchrotron radiation and refined against F2 to R = 9.8%. Arangasite crystallizes in the monoclinic space group P2/a, with unit-cell parameters a = 7.073(1), b = 9.634(2), c = 10.827(2) Å, β = 100.40(1)°, V = 725.7(7) Å3 and Z = 2. The positions of all the independent H atoms were obtained by difference- Fourier techniques and refined in an isotropic approximation. The arangasite crystal structure is built from one-dimensional chains of Al octahedra and PO4 tetrahedra sharing vertices, quasi-isolated SO4 tetrahedra and H2O molecules. All O atoms are involved in the system of H bonding, acting as donors and/or acceptors. Hydrogen bonding serves as the only mechanism providing linkage between the main structural fragments, thus maintaining the framework. Chains of corner-sharing Al octahedra and P tetrahedra in the arangasite structure are topologically identical to the chains built from (Fe, Al) octahedra and P tetrahedra in the crystal structure of destinezite, Fe2(OH)(PO4)(SO4)·6H2O. It has been shown that in spite of very similar chemical formulae, arangasite and sanjuanite, Al2(OH)(PO4)(SO4)·9H2O, are not isotypic.
Major element and oxygen isotope geochemistry of vapour-phase garnet from the Topopah Spring Tuff at Yucca Mountain, Nevada, USA
Authors: Moscati R. J. , Johnson C. A. 
Published: April 2016

AbstractTwenty vapour-phase garnets were studied in two samples of the Topopah Spring Tuff of the Paintbrush Group from Yucca Mountain, in southern Nevada. The Miocene-age Topopah Spring Tuff is a 350 m thick, devitrified, moderately to densely welded ash-flow tuff that is zoned compositionally from high-silica rhyolite to latite. During cooling of the tuff, escaping vapour produced lithophysae (former gas cavities) lined with an assemblage of tridymite (commonly inverted to cristobalite or quartz), sanidine and locally, hematite and/or garnet. Vapour-phase topaz and economic deposits associated commonly with topaz-bearing rhyolites (characteristically enriched in F) were not found in the Topopah Spring Tuff at Yucca Mountain. Based on their occurrence only in lithophysae, the garnets are not primary igneous phenocrysts, but rather crystals that grew from a F-poor magmaderived vapour trapped during and after emplacement of the tuff. The garnets are euhedral, vitreous, reddish brown, trapezohedral, as large as 2 mm in diameter and fractured. The garnets also contain inclusions of tridymite. Electron microprobe analyses of the garnets reveal that they are almandinespessartine (48.0 and 47.9 mol.%, respectively), have an average composition of (Fe1.46Mn1.45Mg0.03Ca0.10)(Al1.93Ti0.02)Si3.01O12and are comparatively homogeneous in Fe and Mn concentrations from core to rim. Composited garnets from each sample site have δ18O values of 7.2 and 7.4%. The associated quartz (after tridymite) has δ18O values of 17.4 and 17.6%, values indicative of reaction with later, low-temperature water. Unaltered tridymite from higher in the stratigraphic section has a δ18O of 11.1% which, when coupled with the garnet δ18O values in a quartz-garnet fractionation equation, indicates isotopic equilibration (vapour-phase crystallization) at temperatures of ∼600°C. This high-temperature mineralization, formed during cooling of the tuffs, is distinct from the later and commonly recognized low-temperature stage (generally 50−70°C) of calcite, quartz and opal secondary mineralization, formed from downward-percolating meteoric water, that locally coats fracture footwalls and lithophysal floors.
Incidence and prevalence of idiopathic pulmonary fibrosis in US adults 18–64 years old
Authors: Raghu Ganesh , Chen Shih-Yin , Hou Qiang , Yeh Wei-Shi , Collard Harold R. 
Published: April 2016

We sought to present the epidemiology of idiopathic pulmonary fibrosis (IPF) in adults 18–64 years old in the USA.From adults aged 18–64 years in a large administrative claims data in 2004–2010, patients with IPF were identified using diagnosis codes. We estimated annual incidence and cumulative prevalence of IPF over time, and examined potential risk factors for the IPF diagnosis.The annual cumulative prevalence increased steadily in the first few years (from 13.4 cases per 100 000 persons in 2005 to 18.2 cases in 2010 per 100 000 persons), which is likely due to a methodological reason, while the annual incidence of IPF decreased over time (from 7.9 cases per 100 000 person-years in 2005 to 5.8 cases in 2010 per 100 000 person-years). The overall decrease was mainly driven by a decreasing trend in the younger patients (aged 18–44 years), while the incidence in older patients remained stable. Consistent trends were observed in subgroups defined by previously published more restrictive algorithms for diagnosis. Older age and male sex were associated with a higher incidence of disease (p<0.05).In US adults younger than 65 years, we observed a decreasing incidence of IPF over time which may partially explain the plateau of cumulative prevalence in the last few years of our data.
Characteristics of effective self-management interventions in patients with COPD: individual patient data meta-analysis
Authors: Jonkman Nini H. , Westland Heleen , Trappenburg Jaap C.A. , Groenwold Rolf H.H. , Bischoff Erik W.M.A. , Bourbeau Jean , Bucknall Christine E. , Coultas David , Effing Tanja W. , Epton Michael , Gallefoss Frode , Garcia-Aymerich Judith , Lloyd Suzanne M. , Monninkhof Evelyn M. , Nguyen Huong Q. , van der Palen Job , Rice Kathryn L. , Sedeno Maria , Taylor Stephanie J.C. , Troosters Thierry , Zwar Nicholas A. , Hoes Arno W. , Schuurmans Marieke J. 
Published: April 2016

It is unknown whether heterogeneity in effects of self-management interventions in patients with chronic obstructive pulmonary disease (COPD) can be explained by differences in programme characteristics. This study aimed to identify which characteristics of COPD self-management interventions are most effective.Systematic search in electronic databases identified randomised trials on self-management interventions conducted between 1985 and 2013. Individual patient data were requested for meta-analysis by generalised mixed effects models.14 randomised trials were included (67% of eligible), representing 3282 patients (75% of eligible). Univariable analyses showed favourable effects on some outcomes for more planned contacts and longer duration of interventions, interventions with peer contact, without log keeping, without problem solving, and without support allocation. After adjusting for other programme characteristics in multivariable analyses, only the effects of duration on all-cause hospitalisation remained. Each month increase in intervention duration reduced risk of all-cause hospitalisation (time to event hazard ratios 0.98, 95% CI 0.97–0.99; risk ratio (RR) after 6 months follow-up 0.96, 95% CI 0.92–0.99; RR after 12 months follow-up 0.98, 95% CI 0.96–1.00).Our results showed that longer duration of self-management interventions conferred a reduction in all-cause hospitalisations in COPD patients. Other characteristics are not consistently associated with differential effects of self-management interventions across clinically relevant outcomes.
The EZH1–SUZ12 complex positively regulates the transcription of NF-κB target genes through interaction with UXT
Authors: Su Shuai-Kun , Li Chun-Yuan , Lei Pin-Ji , Wang Xiang , Zhao Quan-Yi , Cai Yang , Wang Zhen , Li Lianyun , Wu Min 
Published: April 2016

ABSTRACT
Unlike other members of the polycomb group protein family, EZH1 has been shown to positively associate with active transcription on a genome-wide scale. However, the underlying mechanism for this behavior still remains elusive. Here, we report that EZH1 physically interacts with UXT, a small chaperon-like transcription co-activator. UXT specifically interacts with EZH1 and SUZ12, but not EED. Similar to upon knockdown of UXT, knockdown of EZH1 or SUZ12 through RNA interference in the cell impairs the transcriptional activation of nuclear factor (NF)-κB target genes induced by TNFα. EZH1 deficiency also increases TNFα-induced cell death. Interestingly, chromatin immunoprecipitation and the following next-generation sequencing analysis show that H3K27 mono-, di- and tri-methylation on NF-κB target genes are not affected in EZH1- or UXT-deficient cells. EZH1 also does not affect the translocation of the p65 subunit of NF-κB (also known as RELA) from the cytosol to the nucleus. Instead, EZH1 and SUZ12 regulate the recruitment of p65 and RNA Pol II to target genes. Taken together, our study shows that EZH1 and SUZ12 act as positive regulators for NF-κB signaling and demonstrates that EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus.
To the Question of the Tax Debts’ Settlement of Individual Entrepreneurs in the Procedure of Bankruptcy
Authors: Полякова  , Polyakova V. 
Published: April 2016

Th e article is devoted to the issues of settlement of tax arrears at diff erent stages, including bankruptcy
proceedings, examined the positive and negative aspects of the new procedure, proposed new tools to improve its effi ciency
in the context of settlement of tax arrears and the rehabilitation of debtors — self-employed individuals.
Characterization of Coatings Created on Selected Titanium Alloys by Plasma Electrolytic Oxidation
Authors: Rokosz K. , Hryniewicz T. , Malorny W. 
Published: April 2016

Abstract
The SEM and EDS results of coatings obtained on pure niobium and titanium alloys (NiTi and Ti6Al4V) by Plasma Electrolytic Oxidation in the electrolytes containing of 300 g and 600 g copper nitrate in 1 litre of concentrated phosphoric acid at 450 V for 3 minutes, are presented. The obtained coatings are porous and consist mainly of phosphorus within titanium and copper. For each coating, the Cu/P ratios were calculated. The maximum of that coefficient was found for niobium and Ti6Al4V alloy oxidised in the electrolyte containing 600 g of Cu(NO3)2 in 1 dm3 of H3PO4 and equaling to 0.22 (wt%) | 0.11 (at%). The minimum of Cu/P ratio was recorded for NiTi and Ti6Al4V alloys oxidised by PEO in electrolyte consisting of 300 g of copper nitrate in 1 dm3 of concentrated phosphoric acid and equals to 0.12 (wt%) | 0.06 (at%). The middle value of that ratio was recorded for NiTi and it equals to 0.16 (wt%) | 0.08 (at%).
Optimization of Filler Metals Consumption in the Production of Welded Steel Structures
Authors: Pańcikiewicz K. , Tuz L. , Żurek Z. , Rakoczy Ł. 
Published: April 2016

Abstract
The paper presents the some aspects of the optimization of filler metals consumption in the production of welded steel structures. Correct choice of beveling method can allow to decrease cost of production and increase quality. The review of calculation methods of filler metal consumption at the design stage was carried out. Moreover, the practical examples of amount of filler metals calculation were presented and analyzed. The article also contain examples of mobile apps which are makes it easy to see welding costs in just a few seconds. Apps as well as simple excel spreadsheets with correct mathematic equations allows to optimize welding process.
The role of RNA metabolism in neurological diseases
Authors: Alaqeel AM , Abou Al-Shaar H , Shariff RK , Albakr A 
Published: April 2016

AbstractNeurodegenerative disorders are commonly encountered in medical practices. Such diseases can lead to major morbidity and mortality among the affected individuals. The molecular pathogenesis of these disorders is not yet clear. Recent literature has revealed that mutations in RNA-binding proteins are a key cause of several human neuronal-based diseases. This review discusses the role of RNA metabolism in neurological diseases with specific emphasis on roles of RNA translation and microRNAs in neurodegeneration, RNA-mediated toxicity, repeat expansion diseases and RNA metabolism, molecular pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia, and neurobiology of survival motor neuron (SMN) and spinal muscular atrophy.
New records of Psilidae, Piophilidae, Lauxaniidae, Cremifaniidae and Sphaeroceridae (Diptera) from the Czech Republic and Slovakia
Authors: Roháček Jindřich , Barták Miroslav , Preisler Jiří 
Published: April 2016

Abstract
Records of eight rare species of the families Psilidae (4), Piophilidae (1), Lauxaniidae (1), Cremifaniidae (1) and Sphaeroceridae (1) from the Czech Republic, Slovakia and Austria are presented and their importance to the knowledge of the biodiversity of local faunas is discussed along with notes on their biology, distribution and identification. Psilidae: Chamaepsila tenebrica (Shatalkin, 1986) is a new addition to the West Palaearctic fauna (recorded from the Czech Republic and Slovakia); Ch. andreji (Shatalkin, 1991) and Ch. confusa Shatalkin & Merz, 2010 are recorded from the Czech Republic (both Bohemia and Moravia) and Ch. andreji also from Austria for the first time, and Ch. unilineata (Zetterstedt, 1847) is added to the fauna of Moravia. Also Homoneura lamellata (Becker, 1895) (Lauxaniidae) and Cremifania nigrocellulata Czerny, 1904 (Cremifaniidae) are first recorded from Moravia and Copromyza pseudostercoraria Papp, 1976 (Sphaeroceridae) is a new addition to faunas of both the Czech Republic (Moravia only) and Slovakia, and its record from Moravia represents a new northernmost limit of its distribution. Pseudoseps signata (Fallén, 1820) (Piophilidae), an endangered species in the Czech Republic, is reported from Bohemia for second time. Photographs of Chamaepsila tenebrica (male), Pseudoseps signata (living female), Homoneura lamellata (male), Cremifania lanceolata (male) and Copromyza pseudostercoraria (male) are presented to enable recognition of these species.