bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature of shocks revealed by SOFIA OI observations in the Cepheus E protostellar outflow
Authors: Gusdorf A. , Anderl S. , Lefloch B. , Leurini S. , Wiesemeyer H. , Güsten R. , Benedettini M. , Codella C. , Godard B. , Gómez-Ruiz A. I. , Jacobs K. , Kristensen L. E. , Lesaffre P. , Pineau des Forêts G. , Lis D. C. 
Published: April 2017

Context.Protostellar jets and outflows are key features of the star-formation process, and primary processes of the feedback of young stars on the interstellar medium. Understanding the underlying shocks is necessary to explain how jet and outflow systems are launched, and to quantify their chemical and energetic impacts on the surrounding medium.Aims.We performed a high-spectral resolution study of the [OI]63μmemission in the outflow of the intermediate-mass Class 0 protostar Cep E-mm. The goal is to determine the structure of the outflow, to constrain the chemical conditions in the various components, and to understand the nature of the underlying shocks, thus probing the origin of the mass-loss phenomenon.Methods.We present observations of the O i3P1→3P2, OH between2Π1/2J= 3/2 andJ= 1/2 at 1837.8 GHz, and CO (16–15) lines with the GREAT receiver onboard SOFIA towards three positions in the Cep E protostellar outflow: Cep E-mm (the driving protostar), Cep E-BI (in the southern lobe), and Cep E-BII (the terminal position in the southern lobe).Results.The CO (16–15) line is detected at all three positions. The [OI]63μmline is detected in Cep E-BI and BII, whereas the OH line is not detected. In Cep E-BII, we identify three kinematical components in O iand CO. These were already detected in CO transitions and relate to spatial components: the jet, the HH377 terminal bow-shock, and the outflow cavity. We measure line temperature and line integrated intensity ratios for all components. The O icolumn density is higher in the outflow cavity than in the jet, which itself is higher than in the terminal shock. The terminal shock is the region where the abundance ratio of O ito CO is the lowest (about 0.2), whereas the jet component is atomic (N(O i)/N(CO) ~ 2.7). In the jet, we compare the [OI]63μmobservations with shock models that successfully fit the integrated intensity of 10 CO lines. We find that these models most likely do not fit the [OI]63μmdata.Conclusions.The high intensity of O iemission points towards the propagation of additional dissociative or alternative FUV-irradiated shocks, where the illumination comes from the shock itself. A picture emerges from the sample of low-to-high mass protostellar outflows, where similar observations have been performed, with the effects of illumination increasing with the mass of the protostar. These findings need confirmation with more observational constraints and a larger sample.
Traumatic Symmetric Biparietal Extradural Hematoma: Report of Two Cases
Authors: Prasad G. , Sinha Sumit 
Published: April 2017

AbstractTraumatic bilateral epidural hematomas (EDHs) are uncommon and are mostly found in the frontal region because of extension of fracture across the midline and tear of venous sinus. Authors report two cases of mirror image biparietal extradural hematoma after sustaining a high-velocity motor vehicle accident. Both were adult males and had a very low admission GCS of less than 8. Emergency hematoma evacuation was performed bilaterally and good outcomes were achieved in both. Mean follow-up duration was 9 months. The pathophysiologic mechanisms are different from solitary EDH as are the clinical features and outcomes. The rarity of these lesions and surgical nuances are highlighted.
Radiosurgery for Arteriovenous Malformations Using Micro–Multi-leaf Collimators: Analyses of Outcome
Authors: Anjanappa Milan , Jayadevan E. , Bhasi Saju , Koshy Sumod , George Preethi , Arjunan Asha , Raghukumar P. , Mathew Beela 
Published: April 2017

Aim To assess the outcome of patients with AVMs treated using micro-MLC–based radiosurgery at Regional Cancer Centre (RCC), Thiruvananthapuram.
Materials and Methods During January 1 to December 31, 2012, 24 patients were treated with stereotactic radiosurgery (SRS) at RCC. The median age was 28 years (range: 8–58 years). There were 11 males and 13 females. Fifteen patients had prior embolization. All patients were treated with a frameless radiosurgery system using micro-MLC–based linear accelerator (LINAC). Obliteration of the lesion was assessed with either magnetic resonance angiogram (MRA) or digital subtraction angiography (DSA).
Results Nineteen patients who underwent an assessment procedure were evaluable for this study. At median follow-up of 12 months, nearly two-thirds of patients had complete obliteration of the AVM and the rest had partial obliteration. Among patients with complete obliteration, seven patients had an AVM volume of ≤ 3 cc and three-fourths of the patients had AVM score of < 1.5. Further, marginal dose of > 18 Gy resulted in higher obliteration. One patient had an episode of seizure after SRS. No complications or bleed was seen in any of the patients after treatment.
Conclusion Our experience correlates with the existing literature reports, without any significant complications. Longer follow-up is required to assess the complete obliteration and late complications.
Brain Studded with Innumerable Larger Stones: Starry Sky at Night Appearance: Multiple Calcified Giant Tuberculoma with 15 Years of Follow-up
Authors: Satyarthee Guru , Chandra P. , Mahapatra A. 
Published: April 2017

AbstractTuberculosis is rapidly reemerging as a major health problem due to rising incidence of HIV cases across the globe. Central nervous system involvement is rare, but rarely multiple intracerebral granulomas can occur or occasional solitary tuberculoma also develops. The authors report a unique case of 24-year-old woman suffering from pulmonary tuberculosis developed headache and vomiting. Cranial CT scan revealed multiple widespread deposit of intracranial granuloma of sizeable lesion mimicking starry sky at night appearance. Excision of one tuberculoma was done for confirmation of definitive diagnosis, and histopathology was suggestive of tuberculoma. The patient also underwent VP shunt surgery. At last follow-up at 15 years following surgery, she was doing well.
Box Lesion with Single Radiofrequency Clamp
Authors: Shaikhrezai Kasra , Spadaccio Cristiano , Hunter Steven 
Published: April 2017

AbstractWe introduce a maneuver to perform the box lesion as a part of Cox maze IV procedure with single radiofrequency clamp. The maneuver entails engaging the right pulmonary veins with the clamp, then advancing the clamp jaws underneath the superior vena cava through the transverse sinus to include the roof and the left pulmonary veins in the clamp. We regularly use this technique for box lesion with desirable transmurality.
Psychiatrie in der DDR zwischen Aufbruch und Stagnation: Die Brandenburger Thesen zur „Therapeutischen Gemeinschaft“ (1974/76)
Authors: Kumbier Ekkehardt , Haack Kathleen 
Published: April 2017

ZusammenfassungInspiriert vom Konzept des englischen Psychiaters Maxwell Jones entstanden 1974 die „Brandenburger Thesen zur Therapeutischen Gemeinschaft“. Ihr Ziel war es, das therapeutische Milieu in den psychiatrischen Krankenhäusern in der DDR zu verändern. Anhand von Quellen des Bundesarchivs in Berlin und erstmals des Historischen Archivs des Asklepios Fachklinikums Brandenburg sollen Motivation, Umsetzung und Wirkung der sog. Brandenburger Thesen im Kontext der gesellschaftspolitischen Rahmenbedingungen erörtert werden. Obwohl diese keine breite Wirkung auf die psychiatrische Versorgung entfalten konnten, gingen von den Brandenburger Thesen dennoch wichtige Impulse für die Entwicklung der Sozialpsychiatrie und Psychotherapie in der DDR aus. In der Diskussion um das Konzept der „Therapeutischen Gemeinschaft“ wurde deutlich, dass dieses mit den gesellschaftspolitischen Zielen der Staatspartei SED und deren Prinzipien der Kollektiverziehung übereinstimmen sollte.
Balance of microtubule stiffness and cortical tension determines the size of blood cells with marginal band across species
Authors: Dmitrieff Serge , Alsina Adolfo , Mathur Aastha , Nédélec François J. 
Published: April 2017

Significance
The discoidal shape of many blood cells is essential to their proper function within the organism. For blood platelets and other cells, this shape is maintained by the marginal band, which is a closed ring of filaments called microtubules. This ring is elastic and pushes on the cell cortex, a tense polymer scaffold associated with the plasma membrane. Dmitrieff et al. examined how the mechanical balance between these two components determine cell size, uncovering a scaling law that is observed in data collected from 25 species. The analysis also indicated that the cell can resist much higher mechanical challenges than the microtubule ring alone, in the same way as a tent with its cloth is stronger than the poles alone.
Medium-manganese steels processed by austenite-reverted-transformation annealing for automotive applications
Authors: Ma Yan 
Published: April 2017

In the automotive industry, the current development trend of lightweight and low-emission vehicles requests for high-performance materials. Benefiting from an excellent balance of mechanical properties and production cost, medium-Mn steels have attracted extensive interest by materials scientists. Austenite-reverted-transformation annealing plays a vital role in stabilisation of retained austenite and grain refinement, resulting in a considerable amount of retained austenite. Localised deformation phenomenon is usually observed in the ultrafine-grained medium-Mn steels owing to the absence of strain hardening. The occurrence of transformation-induced-plasticity and/or twinning-induced-plasticity effect in austenite improves strain hardening effectively. In the current review, austenite-reverted-transformation annealing treatment routine, mechanical properties and deformation mechanisms and effect of heat treatment on microstructure and mechanical properties of medium-Mn steels are summarised. This review was submitted as part of the 2017 Materials Literature Review Prize of the Institute of Materials, Minerals and Mining run by the Editorial Board of MST. Sponsorship of the prize by TWI Ltd is gratefully acknowledged
Sums of Fourier coefficients of cusp forms of level 𝐷 twisted by exponential functions over arithmetic progressions
Authors: Liu Huan , Zhang Meng 
Published: April 2017

Letggbe a holomorphic Hecke newform of levelDDandλg(n)\lambda _{g}(n)be itsnn-th Fourier coefficient. We prove that the sumSD(N,α,β,X)=∑X>n≤2Xn≡l\textrm {mod}Nλg(n)e(αnβ)\mathcal {S}_{D}(N,\alpha , \beta ,X)=\sum _{\substack {X>n\leq 2X\\ n\equiv l \,\text {\textrm {mod}} N}}\lambda _{g}(n)e(\alpha n^\beta )has an asymptotic formula for the case ofβ=1/2\beta =1/2,α\alphaclose to±2q/c2D2\pm 2\sqrt {q/c^2D_2}, wherell,qq,cc,D2D_2are positive integers satisfying(l,N)=1(l,N)=1,c|Nc|N,D2=D/(c,D)D_2=D/(c, D)andXXis sufficiently large. We obtain upper bounds ofSD(N,α,β,X)\mathcal {S}_{D}(N,\alpha , \beta ,X)for the case of0>β>10>\beta >1andα∈R\alpha \in \mathbb {R}.
Physiological Phenotyping for Personalized Therapy of Uncontrolled Hypertension in Africa
Authors: Akintunde Adeseye , Nondi Justus , Gogo Kennedy , Jones Erika S W , Rayner Brian L , Hackam Daniel G , Spence J David 
Published: April 2017

Abstract

OBJECTIVES
African and African American hypertensives tend to retain salt and water, with lower levels of plasma renin and more resistant hypertension. We tested the hypothesis that physiological phenotyping with plasma renin and aldosterone would improve blood pressure control in uncontrolled hypertensives in Africa.

METHODS
Patients at hypertension clinics in Nigeria, Kenya, and South Africa with a systolic blood pressure &gt;140 mm Hg or diastolic pressure &gt; 90 mm Hg despite treatment were allocated to usual care (UC) vs. physiologically individualized care (PhysRx). Plasma renin activity and aldosterone were measured using ELISA kits. Patients were followed for 1 year; the primary outcome was the percentage of patients achieving blood pressure &lt;140 mm Hg and diastolic &lt;90 mm Hg.

RESULTS
Results are presented for the 94/105 participants who completed the study (42 UC, 52 PhysRx). Control of both systolic and diastolic pressures was obtained in 11.1% of UC vs. 50.0% of PhysRx (P = 0.0001). Systolic control was achieved in 13.9% of UC vs. 60.3% of PhysRx (P = 0.0001); diastolic control in 36.1% of UC vs. 67.2% of PhysRx, vs. (P = 0.003). Number of visits and total number of medications were not significantly different between treatment groups, but there were differences across the sites. There were important differences in prescription of amiloride as specified in the PhysRx algorithm.

CONCLUSIONS
Physiologically individualized therapy based on renin/aldosterone phenotyping significantly improved blood pressure control in a sample of African patients with uncontrolled hypertension. This approach should be tested in African American and other patients with resistant hypertension.
Registered as ISRCTN69440037
Fractional flow reserve and pressure-bounded coronary flow reserve to predict outcomes in coronary artery disease
Authors: Ahn Jung-Min , Zimmermann Frederik M. , Johnson Nils P. , Shin Eun-Seok , Koo Bon-Kwon , Lee Pil Hyung , Park Duk-Woo , Kang Soo-Jin , Lee Seung-Whan , Kim Young-Hak , Lee Cheol Whan , Park Seong-Wook , Pijls Nico H.J. , Park Seung-Jung 
Published: April 2017

Abstract

Aims
Fractional flow reserve (FFR) has proven to its prognostic and therapeutic value. However, the additive prognostic value of coronary flow reserve (CFR) remains unclear. This study sought to investigate the clinical utility of combined FFR and CFR measurements to predict outcomes.

Methods and results
Using the prospective, multicentre Interventional Cardiology Research Incooperation Society–FFR registry, a total of 2088 lesions from 1837 patients were included in this substudy. Based on baseline and hyperaemic pressure gradients, we computed physiologic limits of CFR [the so called pressure-bounded (pb) CFR] and classified lesions as low (&lt;2) or high (≥2). The primary endpoint was major adverse cardiac events (MACE, a composite of cardiac death, myocardial infarction, and revascularization) analysed on a per-patient basis. During a median follow-up of 1.9 years (inter-quartile range: 1.0–3.0 years), MACE occurred in 5.7% of patients with FFR ≤0.80 vs. 2.8% of patients with FFR &gt;0.80 [adjusted hazard ratio (aHR): 2.15, 95% confidence interval (CI): 1.19–3.89; P = 0.011. In contrast, the incidence of MACE did not differ between patients with pb-CFR &lt; 2 vs. pb-CFR ≥ 2 (4.2% vs. 4.2%; aHR: 0.98, CI: 0.60 to 1.58; P = 0.92). Incorporation of FFR significantly improved model prediction of MACE (global χ2 38.8–48.1, P = 0.002). However, pb-CFR demonstrated no incremental utility to classify outcomes (global χ2 48.1–48.2, P &gt; 0.99).

Conclusions
In this large, prospective registry of over 2000 coronary lesions, FFR was strongly associated with clinical outcomes. In contrast, a significant association between pb-CFR and clinical events could not be determined and adding knowledge of pb-CFR did not improve prognostication over FFR alone.
Long-term survival of the mouse ES cell-derived mast cell, MEDMC-BRC6, in mast cell-deficient Kit
W-sh/W-sh mice
Authors: Shibagaki Shohei , Tahara-Hanaoka Satoko , Hiroyama Takashi , Nakamura Yukio , Shibuya Akira 
Published: April 2017

Abstract
Mast cells (MCs) play pivotal roles in allergic reactions and the host defense against microbial infection through the IgE-dependent and IgE-independent signaling pathways. MC lines that can be analyzed both in vitro and in vivo would be useful for the study of MC-dependent immune responses. Here, we investigated the functional characteristics of a mouse embryonic stem cell-derived MC-like cell line, MEDMC-BRC6. The cell line expressed FcεRI and c-Kit and showed degranulation and production of inflammatory cytokines and chemokines, including TNF-α, IL-6 and MCP-1, upon cross-linking FcεRI with IgE. These cytokines and chemokines were also produced by the cell line by stimulation of TLR2 and TLR4. MEDMC-BRC6 survived in the peritoneal cavity and the ear skin for at least 6 months after the transfer into genetically compatible MC-deficient KitW-sh/W-sh mice, in which systemic anaphylaxis was successfully induced. Thus, MEDMC-BRC6 cells represent a potent tool for investigating the functions of MCs in vitro and in vivo.
Electronic clinical quality measure reporting challenges: findings from the Medicare EHR Incentive Program’s Controlling High Blood Pressure Measure
Authors: Heisey-Grove Dawn M , Wall Hilary K , Wright Janet S 
Published: April 2017

Abstract

Objective
To identify physician and practice characteristics associated with high clinical and technical performance on the electronic clinical quality measure (eCQM) that calculates the proportion of patients with hypertension who have controlled blood pressure.

Materials and Methods
The study included 268 602 physicians participating in the Medicare Electronic Health Record Incentive Program between 2011 and 2014. Independent variables included delivery reform participation and physician, practice level, and area characteristics. Successful technical performance was a reported eCQM with non-zero values in both the numerator and denominator. Successful clinical performance was a reported eCQM value of ≥70% hypertension control.

Results
Physicians with longer experience using certified health information technology, participants in delivery reform programs, and specialists that traditionally manage hypertension were 5%–15% more likely to achieve 70% control. Physicians in smaller and rural practices and a subset of physicians unlikely to primarily manage hypertension were more likely to submit measures with a zero value in either the numerator or denominator.

Discussion
More physicians are using eCQMs to track and report their quality improvement efforts. This research presents the first examination of national eCQM data to identify physician and practice-level characteristics associated with performance.

Conclusion
With careful selection of measures relevant to the clinician’s specialty, complete data entry, and support for continuous quality improvement, health care professionals can excel technically and clinically. As care delivery transitions from fee-for-service to quality- and value-based models, high performers may realize financial gains and better patient outcomes. These analyses suggest patterns that may inform steps to improve performance.
The average structural evolution of massive galaxies can be reliably estimated using cumulative galaxy number densities
Authors: Clauwens Bart , Hill Allison , Franx Marijn , Schaye Joop 
Published: April 2017

Abstract
Galaxy evolution can be studied observationally by linking progenitor and descendant galaxies through an evolving cumulative number density (CND) selection. This procedure can reproduce the expected evolution of the median stellar mass from abundance matching. However, models predict an increasing scatter in main progenitor masses at higher redshifts, which makes galaxy selection at the median mass unrepresentative. Consequently, there is no guarantee that the evolution of other galaxy properties deduced from this selection is reliable. Despite this concern, we show that this procedure approximately reproduces the evolution of the average stellar density profile of main progenitors of M ≈ 1011.5M⊙ galaxies, when applied to the EAGLE hydrodynamical simulation. At z ≳ 3.5, the aperture masses disagree by about a factor 2, but this discrepancy disappears when we include the expected scatter in cumulative number densities. The evolution of the average density profile in EAGLE broadly agrees with observations from UltraVISTA and CANDELS, suggesting an inside-out growth history for these massive galaxies over 0 ≲ z ≲ 5. However, for z ≲ 2, the inside-out growth trend is stronger in EAGLE. We conclude that CND matching gives reasonably accurate results when applied to the evolution of the mean density profile of massive galaxies.
Aquatic Exercise for the Treatment of Hip and Knee Osteoarthritis
Authors: Franco Marcia R. , Morelhão Priscilla K. , de Carvalho Augusto , Pinto Rafael Z. 
Published: April 2017

Abstract
&lt;LEAP&gt; highlights the findings and application of Cochrane reviews and other evidence pertinent to the practice of physical therapy. The Cochrane library is a respected source of reliable evidence related to health care. Cochrane systematic reviews explore the evidence for and against the effectiveness and appropriateness of interventions—medications, surgery, education, nutrition, exercise—and the evidence for and against the use of diagnostic tests for specific conditions. Cochrane reviews are designed to facilitate the decisions of clinicians, patients, and others in health care by providing a careful review and interpretation of research studies published in the scientific literature. Each article in this PTJ series summarizes a Cochrane review or other scientific evidence on a single topic and presents clinical scenarios based on real patients or programs to illustrate how the results of the review can be used to directly inform clinical decisions. This article focuses on an older adult with severe knee joint pain. Can aquatic exercise help this patient with knee osteoarthritis?
Pediatric portal hypertension
Authors: Vogel Clarissa Barbon 
Published: April 2017

Abstract:
Pediatric portal hypertension management is a team approach between the patient, the patient's family, the primary caregiver, and specialty providers. Evidence-based practice guidelines have not been established in pediatrics. This article serves as a review for the primary care NP in the management of pediatric portal hypertension, discussing the etiology, pathophysiology, and clinical presentation of pediatric portal hypertension, diagnostic tests, and treatment and management options.
Managing acute bacterial skin and skin structure infections
Authors: Bell Allison M. , King S. Travis , Barber Katie E. , Adcock Kim G. , Wagner Jamie L. , Stover Kayla R. 
Published: April 2017

Abstract:
Acute bacterial skin and skin structure infections (ABSSSI) are some of the most commonly encountered infections worldwide. Hospitalizations as a result of ABSSSI are associated with high mortality. This article discusses the role of oritavancin and dalbavancin, two new lipoglycopeptides, in the context of the other I.V. available standard therapy options.
Six- and Twelve-Month Documented Removal Rates Among Women Electing Postpartum Inpatient Compared to Delayed or Interval Contraceptive Implant Insertions After Medicaid Payment Reform
Authors: Crockett Amy H. , Pickell Lesley Bundon , Heberlein Emily C. , Billings Deborah L. , Mills Benjie 
Published: April 2017

(Abstracted from Contraception 2017;95:71–76)
The safety and efficacy of inpatient postpartum contraceptive implant and intrauterine device insertions is well established. Use of a long-acting reversible contraceptive (LARC) in the postpartum period before discharge from the hospital is feasible and an effective method of birth control to reduce the risk of unintended pregnancy.
Vaginal and Laparoscopic Mesh Hysteropexy for Uterovaginal Prolapse: A Parallel Cohort Study
Authors: Gutman Robert E. , Rardin Charles R. , Sokol Eric R. , Matthews Catherine , Park Amy J. , Iglesia Cheryl B. , Geoffrion Roxana , Sokol Andrew I. , Karram Mickey , Cundiff Geoffrey W. , Blomquist Joan L. , Barber Matthew D. 
Published: April 2017

(Abstracted from Am J Obstet Gynecol 2017;216:38.e1–38.e11)
A hysterectomy is often performed in women undergoing prolapse repair surgery even though the uterus is anatomically normal. There is growing interest among women in uterine conservation at the time of prolapse surgery.