bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing the Role of Government -- The Chinese Experiment
Authors: Bath Vivienne 
Published: July 2016

AbstractChina has taken an original and adventurous approach to the issue of over-regulation through the promulgation of the Administrative Licensing Law, which attempts to limit the number and type of licences and approvals which citizens and enterprises are obliged to obtain from the government. The Administrative Licensing Law has now been in effect for 3 years, and it is therefore an appropriate time to look at licensing and approvals in China. The article focuses on issues relating to the establishment and reduction of licensing requirements, including the actions taken by government to reduce them, the existence of “non-administrative” licensing and approval requirements and issues relating to enforcement. It concludes that although substantial progress has been made, improvements could be made in terms of dealing with the complexity of the system and providing new avenues for enforcement, and that a long-term on-going effort will be required to implement the law fully.
Universal Human Dignity: Some Reflections in the Asian Context
Authors: Lee Man Yee Karen 
Published: July 2016

AbstractThe idea of “human dignity” is accorded a prominent status in domestic constitutions and international human rights law. Its symbolism as a universal ground of human rights sits awkwardly with the absence of a precise definition. The concept has evolved over history and has been interpreted in various ways by people holding different worldviews. The elusive nature of human dignity creates challenges when it is evaluated across cultures. Despite its common association with the concept of liberal democracy, the idea of human worthiness is not necessarily absent in Asian societies, many of which function under alternative political systems.A cross-cultural perspective requires putting aside ethnocentrism and exploring the convergence of views from different belief systems. Examples from Confucianism and Islam may provide insights on how human dignity is understood and realized in various Asian contexts.
377 and the Unnatural Afterlife of British Colonialism in Asia
Authors: Sanders Douglas E. 
Published: July 2016

AbstractThe late 19thcentury saw the spread of anti-homosexual criminal laws to British colonies. The iconic example was the Indian Penal Code of 1860, with its prohibition of ‘carnal intercourse against the order of nature,’ a rewriting of the anti-Catholic ‘buggery’ law of 1534. The language of 377 travelled around the British colonial world. France and certain other parts of Europe had decriminalized homosexual acts a century earlier, so the colonial powers of Europe spoke with different voices. Modern decriminalization is largely the product of the human rights era - sixty years since the Charter of the United Nations and the Universal Declaration of Human Rights.
Unraveling the Puzzle of Differing Rates of FDI and FVCI in India and China
Authors: Lu Haitian , Huang Hong , Deva Swati 
Published: July 2016

AbstractThis study seeks to unravel the puzzle underlying China's and India's differing experiences in attracting two types of foreign investment: namely foreign direct investment (‘FDI’) and foreign venture capital investment (‘FVCI’). Complementing the law and finance literature, we argue that foreign investors prefer the direct investment mode in China despite its poor governance environment because direct investment provides private means of control over the business, and China's institutional environment provides a more facilitating arena for FDI than India's. In contrast, India's legal infrastructure and related institutional settings prove to be better than China's in accommodating foreign portfolio (indirect) investment especially in the form of venture capital. The conclusion of this article has implications for the two countries' legal reform in the direction of the desired type of foreign investment. It also provides comparative insights into the legal institutions of China and India in fostering national innovative capacity and entrepreneurship.
Strange Bedfellows or Soulmates: A Comparison of Merger Regulation in China and Australia
Authors: Healey Deborah J. 
Published: July 2016

AbstractChina and Australia are extremely significant trade partners and investors. Australia has a very well established competition law, now called the Competition and Consumer Law 2010, with a well-established merger regime. China has a relatively new competition law, the Anti-Monopoly Law 2007. This article compares merger control in the two jurisdictions. The Ministry of Commerce (MOFCOM) has already referred to an Australian decision in rejecting a merger, the only reference to a foreign decision to date, which confirms the utility of the comparison. This article critically evaluates the determinations of MOFCOM and compares the approach of the Australian Competition and Consumer Commission (ACCC), the Australian regulator. It assesses the transparency and predictability of procedures and decision-making in the two jurisdictions.
Cavity optomechanical spring sensing of single molecules
Authors: Yu Wenyan , Jiang Wei C , Lin Qiang , Lu Tao 
Published: July 2016

AbstractLabel-free bio-sensing is a critical functionality underlying a variety of health- and security-related applications. Micro-/nano-photonic devices are well suited for this purpose and have emerged as promising platforms in recent years. Here we propose and demonstrate an approach that utilizes the optical spring effect in a high-Q coherent optomechanical oscillator to dramatically enhance the sensing resolution by orders of magnitude compared with conventional approaches, allowing us to detect single bovine serum albumin proteins with a molecular weight of 66 kDa at a signal-to-noise ratio of 16.8. The unique optical spring sensing approach opens up a distinctive avenue that not only enables biomolecule sensing and recognition at individual level, but is also of great promise for broad physical sensing applications that rely on sensitive detection of optical cavity resonance shift to probe external physical parameters.
Peri-exposure protection against Nipah virus disease using a single-dose recombinant vesicular stomatitis virus-based vaccine
Authors: DeBuysscher Blair L , Scott Dana , Thomas Tina , Feldmann Heinz , Prescott Joseph 
Published: July 2016

AbstractNipah virus is a zoonotic paramyxovirus that causes severe disease in humans and animals. Due to almost yearly outbreaks in Bangladesh, and a large outbreak in Malaysia that lead to the shutdown of swine export, Nipah virus is both a threat to public health and the economy. Infection is associated with respiratory distress, encephalitis and human-to-human transmission, resulting in high case fatality rates during outbreaks. This study aims to address the amount of time needed until protection from a recombinant vesicular stomatitis virus-based vaccine candidate expressing the Nipah virus glycoprotein (G), which we have previously shown to protect hamsters and non-human primates when administered 28 days before challenge. We found that a single-dose vaccination, when administered 1 day before challenge, reduced viral load, limited pathology and fully protected hamsters from Nipah virus infection. The vaccine was even partially protective when administered at early time points following challenge with Nipah virus. These data indicate that a single administration of this vaccine to high-risk individuals, such as family members and health-care workers of infected patients, could be protective and useful for reducing human-to-human transmission and curbing an outbreak.
Physical analysis of the shielding capacity for a lightweight apron designed for shielding low intensity scattering X-rays
Authors: Kim Seon Chil , Choi Jeong Ryeol , Jeon Byeong Kyou 
Published: July 2016

AbstractThe purpose of this paper is to develop a lightweight apron that will be used for shielding low intensity radiation in medical imaging radiography room and to apply it to a custom-made effective shielding. The quality of existing aprons made for protecting our bodies from direct radiation are improved so that they are suitable for scattered X-rays. Textiles that prevent bodies from radiation are made by combining barium sulfate and liquid silicon. These materials have the function of shielding radiation in a manner like lead. Three kinds of textiles are produced. The thicknesses of each textile are 0.15 mm, 0.21 mm, and 0.29 mm and the corresponding lead equivalents are 0.039 mmPb, 0.095 mmPb, 0.22 mmPb for each. The rate of shielding space scattering rays are 80% from the distance of 0.5 m, 86% from 1.0 m, and 97% from 1.5 m. If we intend to approach with the purpose of shielding scattering X-rays and low intensity radiations, it is possible to reduce the weight of the apron to be 1/5 compared to that of the existing lead aprons whose weight is typically more than 4 kg. We confirm, therefore, that it is possible to produce lightweight aprons that are used for the purpose of shielding low dose radiations.
Towards a structural biology of the hydrophobic effect in protein folding
Authors: Camilloni Carlo , Bonetti Daniela , Morrone Angela , Giri Rajanish , Dobson Christopher M. , Brunori Maurizio , Gianni Stefano , Vendruscolo Michele 
Published: July 2016

AbstractThe hydrophobic effect is a major driving force in protein folding. A complete understanding of this effect requires the description of the conformational states of water and protein molecules at different temperatures. Towards this goal, we characterise the cold and hot denatured states of a protein by modelling NMR chemical shifts using restrained molecular dynamics simulations. A detailed analysis of the resulting structures reveals that water molecules in the bulk and at the protein interface form on average the same number of hydrogen bonds. Thus, even if proteins are ‘large’ particles (in terms of the hydrophobic effect, i.e. larger than 1 nm), because of the presence of complex surface patterns of polar and non-polar residues their behaviour can be compared to that of ‘small’ particles (i.e. smaller than 1 nm). We thus find that the hot denatured state is more compact and richer in secondary structure than the cold denatured state, since water at lower temperatures can form more hydrogen bonds than at high temperatures. Then, using Φ-value analysis we show that the structural differences between the hot and cold denatured states result in two alternative folding mechanisms. These findings thus illustrate how the analysis of water-protein hydrogen bonds can reveal the molecular origins of protein behaviours associated with the hydrophobic effect.
Grid-texture mechanisms in human vision: Contrast detection of regular sparse micro-patterns requires specialist templates
Authors: Baker Daniel H. , Meese Tim S. 
Published: July 2016

AbstractPrevious work has shown that human vision performs spatial integration of luminance contrast energy, where signals are squared and summed (with internal noise) over area at detection threshold. We tested that model here in an experiment using arrays of micro-pattern textures that varied in overall stimulus area and sparseness of their target elements, where the contrast of each element was normalised for sensitivity across the visual field. We found a power-law improvement in performance with stimulus area, and a decrease in sensitivity with sparseness. While the contrast integrator model performed well when target elements constituted 50–100% of the target area (replicating previous results), observers outperformed the model when texture elements were sparser than this. This result required the inclusion of further templates in our model, selective for grids of various regular texture densities. By assuming a MAX operation across these noisy mechanisms the model also accounted for the increase in the slope of the psychometric function that occurred as texture density decreased. Thus, for the first time, mechanisms that are selective for texture density have been revealed at contrast detection threshold. We suggest that these mechanisms have a role to play in the perception of visual textures.
Characterisation of a New Fungal Immunomodulatory Protein from Tiger Milk mushroom, Lignosus rhinocerotis
Authors: Pushparajah V. , Fatima A. , Chong C. H. , Gambule T. Z. , Chan C. J. , Ng S. T. , Tan C. S. , Fung S. Y. , Lee S. S. , Tan N. H. , Lim R. L. H. 
Published: July 2016

AbstractLignosus rhinocerotis(Tiger milk mushroom) is an important folk medicine for indigenous peoples in Southeast Asia. We previously reported itsde novoassembled 34.3 Mb genome encoding a repertoire of proteins including a putative bioactive fungal immunomodulatory protein. Here we report the cDNA of this new member (FIP-Lrh) with a homology range of 54–64% to FIPs from other mushroom species, the closest is with FIP-glu (LZ-8) (64%) fromGanoderma lucidum.The FIP-Lrh of 112 amino acids (12.59 kDa) has a relatively hydrophobic N-terminal. Its predicted 3-dimensional model has identical folding patterns to FIP-fve and contains a partially conserved and more positively charged carbohydrates binding pocket. Docking predictions of FIP-Lrh on 14 glycans commonly found on cellular surfaces showed the best binding energy of −3.98 kcal/mol to N-acetylgalactosamine and N-acetylglucosamine. Overexpression of a 14.9 kDa soluble 6xHisFIP-Lrh was achieved in pET-28a(+)/BL21 and the purified recombinant protein was sequence verified by LC-MS/MS (QTOF) analysis. The ability to haemagglutinate both mouse and human blood at concentration ≥0.34 μM, further demonstrated its lectin nature. In addition, the cytotoxic effect of 6xHisFIP-Lrh on MCF-7, HeLa and A549 cancer cell lines was detected at IC50of 0.34 μM, 0.58 μM and 0.60 μM, respectively.
Deep sequencing reveals global patterns of mRNA recruitment during translation initiation
Authors: Gao Rong , Yu Kai , Nie Jukui , Lian Tengfei , Jin Jianshi , Liljas Anders , Su Xiao-Dong 
Published: July 2016

AbstractIn this work, we developed a method to systematically study the sequence preference of mRNAs during translation initiation. Traditionally, the dynamic process of translation initiation has been studied at the single molecule level with limited sequencing possibility. Using deep sequencing techniques, we identified the sequence preference at different stages of the initiation complexes. Our results provide a comprehensive and dynamic view of the initiation elements in the translation initiation region (TIR), including the S1 binding sequence, the Shine-Dalgarno (SD)/anti-SD interaction and the second codon, at the equilibrium of different initiation complexes. Moreover, our experiments reveal the conformational changes and regional dynamics throughout the dynamic process of mRNA recruitment.
From entanglement witness to generalized Catalan numbers
Authors: Cohen E. , Hansen T. , Itzhaki N. 
Published: July 2016

AbstractBeing extremely important resources in quantum information and computation, it is vital to efficiently detect and properly characterize entangled states. We analyze in this work the problem of entanglement detection for arbitrary spin systems. It is demonstrated how a single measurement of the squared total spin can probabilistically discern separable from entangled many-particle states. For achieving this goal, we construct a tripartite analogy between the degeneracy of entanglement witness eigenstates, tensor products of SO(3) representations and classical lattice walks with special constraints. Within this framework, degeneracies are naturally given by generalized Catalan numbers and determine the fraction of states that are decidedly entangled and also known to be somewhat protected against decoherence. In addition, we introduce the concept of a “sterile entanglement witness”, which for large enough systems detects entanglement without affecting much the system’s state. We discuss when our proposed entanglement witness can be regarded as a sterile one.
Cost-effectiveness of hemodialysis and peritoneal dialysis: A national cohort study with 14 years follow-up and matched for comorbidities and propensity score
Authors: Chang Yu-Tzu , Hwang Jing-Shiang , Hung Shih-Yuan , Tsai Min-Sung , Wu Jia-Ling , Sung Junne-Ming , Wang Jung-Der 
Published: July 2016

AbstractAlthough treatment for the dialysis population is resource intensive, a cost-effectiveness analysis comparing hemodialysis (HD) and peritoneal dialysis (PD) by matched pairs is still lacking. After matching for clinical characteristics and propensity scores, we identified 4,285 pairs of incident HD and PD patients from a Taiwanese national cohort during 1998–2010. Survival and healthcare expenditure were calculated by data of 14-year follow-up and subsequently extrapolated to lifetime estimates under the assumption of constant excess hazard. We performed a cross-sectional EQ–5D survey on 179 matched pairs of prevalent HD and PD patients of varying dialysis vintages from 12 dialysis units. The product of survival probability and the mean utility value at each time point (dialysis vintage) were summed up throughout lifetime to obtain the quality-adjusted life expectancy (QALE). The results revealed the estimated life expectancy between HD and PD were nearly equal (19.11 versus 19.08 years). The QALE’s were also similar, whereas average lifetime healthcare costs were higher in HD than PD (237,795 versus 204,442 USD) and the cost-effectiveness ratios for PD and HD were 13,681 and 16,643 USD per quality-adjusted life year, respectively. In conclusion, PD is more cost-effective than HD, of which the major determinants were the costs for the dialysis modality and its associated complications.
Surgical management of postpartum haemorrhage: survey of French obstetricians
Authors: Bouet Pierre-Emmanuel , Brun Stéphanie , Madar Hugo , Schinkel Elsa , Merlot Benjamin , Sentilhes Loïc 
Published: July 2016

AbstractThe aim of our study was to assess the theoretical and practical knowledge of French obstetricians about the surgical management of postpartum haemorrhage (PPH). Our study is a national anonymous self-administered survey. A total of 363 obstetricians responded to this questionnaire between December 2013 and April 2014. Questionnaire sent through email to all French obstetricians who are members of either of two federations of hospital-based obstetricians. Answers were collected until the end of June 2014. The main outcome measure was obstetricians’ level of mastery of each surgical technique. The results were analysed descriptively (proportions). Only the 286 questionnaires fully completed were analysed; the complete response rate was 23% (286/1246). In all, 33% (95/286) of the responding obstetricians reported that they had not mastered sufficiently or even at all the technique for bilateral ligation of the uterine arteries, 37% (105/286) for uterine compression suture, 62% (178/286) for ligation of the internal iliac arteries, and 47% (134/286) for emergency peripartum hysterectomy. In all, 18% (52/286) of respondents stated that they had not mastered any of these techniques. Our study shows that a worrisome number of French obstetricians reported insufficient mastery of the surgical techniques for PPH management.
Dynamic spatiotemporal trends of imported dengue fever in Australia
Authors: Huang Xiaodong , Yakob Laith , Devine Gregor , Frentiu Francesca D. , Fu Shiu-Yun , Hu Wenbiao 
Published: July 2016

AbstractDengue fever (DF) epidemics in Australia are caused by infected international travellers and confined to Northern Queensland where competent vectors exist. Recent analyses suggest that global trade and climate change could lead to the re-establishment of Ae. aegypti across the country and promote the spread of dengue nationally. This study aimed to describe the dynamic spatiotemporal trends of imported DF cases and their origins, identify the current and potential future high-risk regions and locate areas that might be at particular risk of dengue transmission should competent mosquito vectors expand their range. Our results showed that the geographical distribution of imported DF cases has significantly expanded in mainland Australia over the past decade. In recent years, the geographical distribution of source countries of DF has expanded from the Pacific region and Asia to include Africa and the Americas. Australia is now exposed to dengue importations from all of the regions involved in the current global pandemic. The public health implications of a range expansion of dengue mosquito vectors are severe. Enhanced mosquito surveillance in those areas that have high imported cases is called for to reduce emerging threats from this globally expanding pathogen.
Genomic epidemiology and global diversity of the emerging bacterial pathogen Elizabethkingia anophelis
Authors: Breurec Sebastien , Criscuolo Alexis , Diancourt Laure , Rendueles Olaya , Vandenbogaert Mathias , Passet Virginie , Caro Valérie , Rocha Eduardo P. C. , Touchon Marie , Brisse Sylvain 
Published: July 2016

AbstractElizabethkingia anophelis is an emerging pathogen involved in human infections and outbreaks in distinct world regions. We investigated the phylogenetic relationships and pathogenesis-associated genomic features of two neonatal meningitis isolates isolated 5 years apart from one hospital in Central African Republic and compared them with Elizabethkingia from other regions and sources. Average nucleotide identity firmly confirmed that E. anophelis, E. meningoseptica and E. miricola represent demarcated genomic species. A core genome multilocus sequence typing scheme, broadly applicable to Elizabethkingia species, was developed and made publicly available (http://bigsdb.pasteur.fr/elizabethkingia). Phylogenetic analysis revealed distinct E. anophelis sublineages and demonstrated high genetic relatedness between the African isolates, compatible with persistence of the strain in the hospital environment. CRISPR spacer variation between the African isolates was mirrored by the presence of a large mobile genetic element. The pan-genome of E. anophelis comprised 6,880 gene families, underlining genomic heterogeneity of this species. African isolates carried unique resistance genes acquired by horizontal transfer. We demonstrated the presence of extensive variation of the capsular polysaccharide synthesis gene cluster in E. anophelis. Our results demonstrate the dynamic evolution of this emerging pathogen and the power of genomic approaches for Elizabethkingia identification, population biology and epidemiology.