bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice
Authors: Guo Yi , Cai Chuanbin , Zhang Bingjie , Tan Bo , Tang Qinmin , Lei Zhifeng , Qi Xiaolan , Chen Jiang , Zheng Xiaojiang , Zi Dan , Li Song , Tan Jun 
Published: October 2024

AbstractAlzheimer’s Disease (AD), as the most common neurodegenerative disease worldwide, severely impairs patients’ cognitive functions. Although its exact etiology remains unclear, the abnormal aggregations of misfolded β-amyloid peptide and tau protein are considered pivotal in its pathological progression. Recent studies identify ubiquitin-specific protease 11 (USP11) as the key regulator of tau deubiquitination, exacerbating tau aggregation and AD pathology. Thereby, inhibiting USP11 function, via either blocking USP11 activity or lowering USP11 protein level, may serve as an effective therapeutic strategy against AD. Our research introduces IsoLiPro, a unique lithium isobutyrate-L-proline coordination compound, effectively lowers USP11 protein level and enhances tau ubiquitination in vitro. Additionally, long-term oral administration of IsoLiPro dramatically reduces total and phosphorylated tau levels in AD transgenic mice. Moreover, IsoLiPro also significantly lessens β-amyloid deposition and synaptic damage, improving cognitive functions in these animal models. These results indicate that IsoLiPro, as a novel small-molecule USP11 inhibitor, can effectively alleviate AD-like pathologies and improve cognitive functions, offering promise as a potential multi-targeting therapeutic agent against AD.
Foundation models for cardiovascular disease detection via biosignals from digital stethoscopes
Authors: Mathew George , Barbosa Daniel , Prince John , Venkatraman Subramaniam 
Published: October 2024

AbstractAuscultation of the heart and the electrocardiogram (ECG) are two central components of the cardiac exam. Recent innovations of the stethoscope have enabled the simultaneous acquisition of a high-quality digital acoustic signal and ECG. We present foundation models trained on phonocardiogram (PCG) and ECG data collected from digital stethoscopes during routine clinical practice. We show that these foundation models that are pre-trained on large unlabeled datasets in a self-supervised manner can be fine-tuned for a variety of cardiovascular disease detection tasks. This is the first study that builds foundation models specifically for synchronously captured PCG and ECG data. Our approach is based on the recently developed masked autoencoder framework which we extend to handle multiple signals that are synchronously captured. This paradigm makes it possible to use large capacity models leading to superior performance even though the size of datasets with medical label annotations may be limited.
A covalent organic polymer containing dative B ← N bonds: synthesis, single crystal structure, and physical properties
Authors: Wu Jinghang , Liu Jiahe , Rao Limei , Long Yunchen , Gu Qianfeng , Wang Xin , Zhang Lei , Kang Fangyuan , Jiang Lang , Lei Dangyuan , Zhang Qichun 
Published: October 2024

A covalent organic polymer (COP) single crystal (CityU-30) based on dative B ← N bond was prepared. CityU-30 exhibits a pronounced photothermal effect.
The Use of Pharyngeal High-Resolution (Impedance) Manometry in Patients With Head and Neck Cancer: A Scoping Review
Authors: Neijman Marise , van Mierden Stevie , Karakullukcu M. Baris , Hilgers Frans J. M. , van den Brekel Michiel W. M. , van der Molen Lisette 
Published: October 2024

Purpose:
This scoping review aims to summarize and explore current literature on the usefulness and clinical implications of pharyngeal high-resolution (impedance) manometry (HRM/HRIM) in head and neck cancer (HNC) patients.

Method:
Three online databases (MEDLINE, Embase, Scopus, and additionally Google Scholar) were searched until December 2023. Studies using pharyngeal HRM/HRIM to assess swallowing or voicing in HNC patients, written in any language and published in peer-reviewed journals, were considered eligible. Quality check was performed using the Quality Assessment Tool for Quantitative Studies from the Effective Public Healthcare Practice Project. Information about the study population and HRM/HRIM data (equipment, protocol, analysis, and outcomes) were extracted.

Results:
Eight papers met the inclusion criteria, six utilizing HRM and two HRIM. The study design consisted of case-series (five) and case–control (three). The quality assessment indicated a weak global rating for seven papers and a moderate rating for one for the remaining study. Findings suggest that HNC patients with dysphagia suffer from reduced pressures in the pharynx and upper esophageal sphincter compared to healthy individuals, potentially influenced by tumor characteristics and treatment. Decreased pressures may indicate poor functioning of swallowing musculature and mechanism.

Conclusions:
Pharyngeal HRM/HRIM is sparsely used for swallowing assessment in HNC patients. However, wider use seems warranted, as it can offer valuable insights into swallowing biomechanics. This can help quantifying the degree and timing of pressures involved in swallowing (problems) and holds potential for clinical applications, such as earlier diagnosis of radiation-induced therapy or surgery complications. Additionally, it can be beneficial in evaluating therapeutic swallowing strategies.
A First-Person Account of Caring for a Parent With Dysphagia
Authors: Ramkishun Amanda , Faur Madeleine , Namasivayam-MacDonald Ashwini 
Published: October 2024

Purpose:
Research has shown that caregiver burden is compounded by dysphagia experienced by the care recipient. However, little is known about the caregiver perception of the caregiving experience, highlighting both the positive and negative experiences. As such, the purpose of this clinical focus article was to provide a first-person account of an adult caregiver of an aging parent with dysphagia and relate their experiences to current literature to inform clinical practice.

Method:
The caregiver provided a detailed account of her experiences caring for her father with dysphagia. Her account was analyzed to identify recurring themes in the literature regarding the caregiving experience and to identify gaps in dysphagia-related caregiver support. The caregiver's story is organized into seven main sections: (a) life before dysphagia, (b) dysphagia onset and diagnosis, (c) dysphagia management and support, (d) community support, (e) impact on family relationships, (f) social and emotional health, and (g) current perspectives on the caregiving experience.

Conclusions:
The challenges associated with caregiving clearly impact the caregiver's overall well-being, but she received abundant support from her family, community-based speech-language pathologist, and caregiver support groups. The caregiver's experiences, while not applicable to every caregiver caring for a loved one with dysphagia, can offer valuable insights to clinicians and other caregivers facing similar situations.
Hearing Impairment: Reduced Pupil Dilation Response and Frontal Activation During Degraded Speech Perception
Authors: Zekveld Adriana A. , Kramer Sophia E. , Heslenfeld Dirk J. , Versfeld Niek J. , Vriend Chris 
Published: October 2024

Purpose:
A relevant aspect of listening is the effort required during speech processing, which can be assessed by pupillometry. Here, we assessed the pupil dilation response of normal-hearing (NH) and hard of hearing (HH) individuals during listening to clear sentences and masked or degraded sentences. We combined this assessment with functional magnetic resonance imaging (fMRI) to investigate the neural correlates of the pupil dilation response.

Method:

Seventeen NH participants (
M
age
= 46 years) were compared to 17 HH participants (
M
age
= 45 years) who were individually matched in age and educational level. Participants repeated sentences that were presented clearly, that were distorted, or that were masked. The sentence intelligibility level of masked and distorted sentences was 50% correct. Silent baseline trials were presented as well. Performance measures, pupil dilation responses, and fMRI data were acquired.

Results:
HH individuals had overall poorer speech reception than the NH participants, but not for noise-vocoded speech. In addition, an interaction effect was observed with smaller pupil dilation responses in HH than in NH listeners for the degraded speech conditions. Hearing impairment was associated with higher activation across conditions in the left superior temporal gyrus, as compared to the silent baseline. However, the region of interest analysis indicated lower activation during degraded speech relative to clear speech in bilateral frontal regions and the insular cortex, for HH compared to NH listeners. Hearing impairment was also associated with a weaker relation between the pupil response and activation in the right inferior frontal gyrus. Overall, degraded speech evoked higher frontal activation than clear speech.

Conclusion:
Brain areas associated with attentional and cognitive-control processes may be increasingly recruited when speech is degraded and are related to the pupil dilation response, but this relationship is weaker in HH listeners.

Supplemental Material:

https://doi.org/10.23641/asha.27162135
Imitation of Multisyllabic Items by Children With Developmental Language Disorder: Evidence for Word-Level Atypical Speech Envelope and Pitch Contours
Authors: Parvez Lyla , Keshavarzi Mahmoud , Richards Susan , Di Liberto Giovanni M. , Goswami Usha 
Published: October 2024

Purpose:
Developmental language disorder (DLD) is a multifaceted disorder. Recently, interest has grown in prosodic aspects of DLD, but most investigations of possible prosodic causes focus on speech perception tasks. Here, we focus on speech production from a speech amplitude envelope (AE) perspective. Perceptual studies have indicated a role for difficulties in AE processing in DLD related to sensory/neural processing of prosody. We explore possible matching AE difficulties in production.

Method:

Fifty-seven children with and without DLD completed a computerized imitation task, copying aloud 30 familiar targets such as “alligator.” Children with DLD (
n
= 20) were compared with typically developing children (age-matched controls [AMC],
n
= 21) and younger language controls (YLC,
n
= 16). Similarity of the child's productions to the target in terms of the continuous AE and pitch contour was computed using two similarity metrics, correlation, and mutual information. Both the speech AE and the pitch contour contain important information about stress patterning and intonational information over time.

Results:
Children with DLD showed significantly reduced imitation for both the AE and pitch contour metrics compared to AMC children. The opportunity to repeat the targets had no impact on performance for any group. Word length effects were similar across groups.

Conclusions:
The spoken production of multisyllabic words by children with DLD is atypical regarding both the AE and the pitch contour. This is consistent with a theoretical explanation of DLD based on impaired sensory/neural processing of low-frequency (slow) amplitude and frequency modulations, as predicted by the temporal sampling theory.

Supplemental Material:

https://doi.org/10.23641/asha.27165690
A new forward‐flyback converter without right half plane zero
Authors: Ahmadi Sayed Mohsen , Abjadi Navid Reza , Mirmoghtadaei Sayed Vahid , Adib Ehsan 
Published: October 2024

AbstractDue to its unique features, the flyback converter is widely used to convert DC to DC power. This converter has a non‐minimum phase (NMP) dynamic behavior, which is one of its most significant disadvantages. By changing the topology of the flyback converter to a forward‐flyback (FF) converter, the dynamic behavior of the converter can be minimum phase (MP) while the main advantages of the flyback converter such as isolation of the output from the input and simple topology are maintained. This article proposes an innovative FF converter topology by doubling the forward path and adding only one diode and one capacitor. In addition to better dynamic behavior, the proposed double FF (DFF) converter has the same advantages as the conventional FF converter. A new method is used to obtain the transfer function of the output voltage to the duty cycle of the proposed converter. The converter is designed in continuous conduction mode (CCM) with minimum phase dynamics. Finally, simulation and experimental results of both conventional FF and the proposed DFF converters are obtained and compared to validate the superiority of the proposed converter.
Self-Etching Ceramic Primer Affects Surface Topography and Roughness of Two Zirconia-Reinforced Lithium Silicate Ceramics
Authors: Alhalabi Feras 
Published: October 2024

Abstract
Objective This article evaluates the etching efficacy of a self-etching ceramic primer (SECP) on zirconia-reinforced lithium silicate (ZLS) ceramics.
Materials and Methods Celtra Duo (DeguDent GmbH, Hanau-Wolfgang, Germany) and Vita Suprinity (Vita Zahnfabrik, Bad Säckingen, Germany) were used in this study. A total of 36 ceramic slices were prepared from each ceramic material and randomly distributed into three groups according to the surface treatment applied (n = 12 per group). Group 1 (polished) was polished with silicon carbide paper discs and did not undergo any surface treatment; group 2 (SECP) was surface treated with SECP (Monobond Etch and Prime, Ivoclar Vivadent, Schaan, Liechtenstein); group 3 (hydrofluoric acid [HF]) was surface treated with 4.7% HF etching. Half of the specimens (n = 6) from each group were gold-sputtered, and the surface topographic alterations were evaluated by scanning electron microscopy at magnifications of 5,000× and 10,000 × . The surface roughness of the other half (n = 6) from each group was tested using a three-dimensional optical profiler. Data were statistically analyzed using two-way analysis of variance and Tukey's multiple comparisons test.
Results Both SECP and HF etching surface treatments resulted in a statistically significant increase (p < 0.05) in the surface roughness of both ceramic materials, compared to that of their respective control group specimens (polished). HF etching resulted in a significant dissolution of the glassy phase of each ceramic.
Conclusion SECP can effectively etch ZLS ceramics. The etching patterns created after the application of SECP were mild compared to those produced by HF etching. The topographic surface features of ceramics are affected by both, surface treatment and material composition.
The Relationship between Delirium and Dementia
Authors: Umoh Mfon E. , Fitzgerald Dennis , Vasunilashorn Sarinnapha M. , Oh Esther S. , Fong Tamara G. 
Published: October 2024

AbstractDelirium and dementia are common causes of cognitive impairment in older adults. They are distinct but interrelated. Delirium, an acute confusional state, has been linked to the chronic and progressive loss of cognitive ability seen in dementia. Individuals with dementia are at higher risk for delirium, and delirium itself is a risk factor for incident dementia. Additionally, delirium in individuals with dementia can hasten underlying cognitive decline. In this review, we summarize recent literature linking these conditions, including epidemiological, clinicopathological, neuroimaging, biomarker, and experimental evidence supporting the intersection between these conditions. Strategies for evaluation and diagnosis that focus on distinguishing delirium from dementia in clinical settings and recommendations for delirium prevention interventions for patients with dementia are presented. We also discuss studies that provide evidence that delirium may be a modifiable risk factor for dementia and consider the impact of delirium prevention interventions on long-term outcomes.
Characterization of Nonsmall Cell Lung Carcinoma in Limited Biopsy Samples and Identifying Optimal Immunohistochemical Marker Combinations in Resource-Constrained Setup: An Institutional Experience
Authors: Grover Ankita , Osama Md Ali , Dhawan Shashi 
Published: October 2024

Abstract
Background The incorporation of immunohistochemical markers in the analysis of small biopsy samples, as outlined in the fourth edition of the World Health Organization Blue books, represents a noteworthy advancement in the diagnosis of advanced-stage lung carcinoma. This improved the histological classification for poorly differentiated nonsmall cell lung carcinomas (NSCLCs), especially in small biopsy specimens. Despite challenges in obtaining viable cells from diminutive tumor samples, a focused immunohistochemical panel effectively distinguishes histological types in most NSCLC. This preserves tissue for subsequent molecular testing.
Material and Methods This study examined 130 consecutive lung biopsy cases initially diagnosed as NSCLC, including various biopsy types (transbronchial, endobronchial, ultrasound-guided, computed tomography-guided). Carcinomas were categorized based on specific characteristics, such as glands and/or mucin for adenocarcinomas, keratinization and/or intercellular bridges for squamous cell carcinomas, and recognition of poorly differentiated NSCLC. Cases lacking clear morphological attributes underwent reclassification using immunohistochemical markers (TTF1, Napsin A, p63, and p40).
Results TTF1 exhibited superior sensitivity (97.56%) and specificity (96.77%) for adenocarcinoma compared with Napsin A, with sensitivity and specificity at 90.24 and 93.3%, respectively. p63 and p40 demonstrated 100% sensitivity for squamous cell carcinoma, with p40 being more specific than p63 (100% vs. 82.92%). Using TTF1 and p63 as a conventional panel, 87% of cases were subtyped. However, the combination of TTF1 and p40 achieved accurate classification in 94.66% (71/75) of cases, and all four markers allowed subtype identification in 97.2% (73/75) of cases.
Conclusion In a resource-constrained setting, subtyping NSCLC in small biopsy can be effectively accomplished using a minimal panel consisting of TTF1 and p40 immunohistochemical markers.
Different roads take me home: the nonlinear relationship between distance and flows during China’s Spring Festival
Authors: Luan Xiaofan , Paryzat Hurex , Chu Jun , Shu Xinyi , Gu Hengyu , Tong De , Li Bowen 
Published: October 2024

AbstractHuman mobility modelling has attracted scholarly attention from physics-based methods and social science explanatory approaches. However, there is limited knowledge of the nonlinear relationship of flows and distance in intercity mobility and regional differences in the nonlinear relationship. Focusing on China’s long-distance and large-scale mobility during the Spring Festival, this paper develops a framework to explain the nonlinear relationship. Using the Gradient Boosting Decision Tree (GBDT) model and Tencent Big Data, we find that there are three types of nonlinear relationships, namely plateau (almost zero distance decay parameter), drop (decreasing distance decay parameter) and rebound (increasing distance decay parameter after decreasing). The provincial differences also reveal that the nonlinear relationships depend on the domestic relative location and the intra-provincial urban system. This result shows that the cities in the coastal province enjoy a more inclusive spatial structure, which supports the migration from the periphery of the province. In contrast, the inland cities are concerned with embracing the migrants and settling them down.
Contrasts in the Spanish and Korean external possession constructions
Authors: Aranovich Raúl , Kim Jong-Bok 
Published: October 2024

Abstract
In many languages, an argument external to a nominal can be interpreted as a possessor of that nominal. Korean and
Spanish both have such constructions, but the external possessors contrast in their case features, grammatical functions,
distribution, and semantic properties (e.g. alienability). This paper develops a Construction Grammar account that treats external
possessors as unselected arguments licensed through a conventional implicature.
Pragmatics and cognition in Easy Language
Authors: Fuchs Julia 
Published: October 2024

Abstract
A core area of pragmatics is conversational implicatures, where speakers imply a meaning that is not part of what is literally said. Not all people have the ability to easily understand such common (implicit) forms of communication. For these people, Easy Language has been developed, i.e. a form of barrier-free communication with substantially simplified syntax and lexis. Moreover, Easy Language is based on the principle of maximum explicitness. However, the heterogeneous target groups and the different types of implicature have not been systematically taken into account. Therefore, this article is the first to take an in-depth look at conversational implicatures in Easy Language. It shows that a universal principle of maximum explicitness for Easy Language is too short-sighted. Instead, the principle of explicitness must be considered in relation to the different target groups and the types of implicature. The article provides an impulse for further (empirical) research in this emerging field.
Four-year-olds’ visuospatial cognitive abilities and their relation to observer‑viewpoint gestures across three
communicative tasks
Authors: Boden Ulrich J. , Kern Friederike , Koutalidis Sofia , Abramov Olga , Nemeth Anne , Kopp Stefan , Rohlfing Katharina J. 
Published: October 2024

Abstract
The gesture-as-simulated-action framework explains the occurrence of iconic gestures. Accordingly, simulated
visual imagery gives rise to observer-viewpoint, whereas simulated motor imagery gives rise to character-viewpoint gestures.
Because little is known about whether this relationship is either the product of becoming a competent speaker in different
communicative tasks or exists from an early age, we investigated 4-year-olds. In the first session, 55 children performed three
different communicative tasks. In the second session, we administered a SON-R non-verbal intelligence test to assess children’s
cognitive abilities. Results revealed a strong association between the frequency with which children used observer-viewpoints
gestures and their scores in visual processing abilities. Because the association between gestures and visuospatial cognitive
abilities was found across three communicative tasks, we can propose that it is a general ability rather than a phenomenon of
task-specific discourse competence. We discuss these findings in terms of gestural threshold and cognitive offloading.