bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracing the development of spatially modulated gestures in the manual modality in nonsigning Chinese-speaking children
Authors: SO WING-CHEE , WONG KIT-YI MIRANDA 
Published: November 2017

ABSTRACTSpeakers employ gestures to identify nonpresent objects in nonneutral locations (e.g., pointing to the left to indicate a toy car) and maintain the same spatial locations to indicate the same objects throughout the discourse. These kinds of gestures are referred to as shared-location spatially modulated gestures. Previous research showed that native signers form associations between locations and objects as early as age 5. We examined whether nonsigning children also produced shared-location spatially modulated gestures as early as age 5, and if so, whether such ability is associated with verbal memory, spatial memory, and eductive reasoning (i.e., the ability to derive meaning from the complex situations). Our results showed that nonsigning children use spatial devices in their gestures as early as age 5, but such ability is not well developed until age 7 to 11. It is interesting that different types of cognitive skills may come into play in the production of shared-location spatially modulated gestures across different age groups. We found significant correlations between the production of this type of gesture and spatial memory in the younger children and eductive reasoning in the older children. Thus, there is possibly a developmental shift of the cognitive processes involved in the production of shared-location spatially modulated gestures.
ETHICS OF SMART HOUSE WELFARE TECHNOLOGY FOR OLDER ADULTS: A SYSTEMATIC LITERATURE REVIEW
Authors: Sánchez Veralia Gabriela , Taylor Ingrid , Bing-Jonsson Pia Cecilie 
Published: November 2017

Background:The University College of Southeast Norway has an on-going project to develop a smart house welfare system to allow older adults and people with disabilities to remain in their homes for as long as they wish in safe, dignified, living conditions.Objectives:This article reviews reported ethical challenges to implementing smart houses for older adults.Methods:A systematic literature review identified twenty-four articles in English, French, Spanish, and Norwegian, which were analyzed and synthesized using Hofmann's question list to investigate the reported ethical challenges.Results:Smart houses offer a promising way to improve access to home care for older adults and people with disabilities. However, important ethical challenges arise when implementing smart houses, including cost-effectiveness, privacy, autonomy, informed consent, dignity, safety, and trust.Conclusions:The identified ethical challenges are important to consider when developing smart house systems. Due to the limitations of smart house technology, designers and users should be mindful that smart houses can achieve a safer and more dignified life-style but cannot solve all the challenges related to ageing, disabilities, and disease. At some point, smart houses can no longer help persons as they develop needs that smart houses cannot meet.
A survey of diacritic restoration in abjad and alphabet writing systems
Authors: ASAHIAH FRANKLIN ỌLÁDIÍPỌ̀ , ỌDẸ́JỌBÍ ỌDẸ́TÚNJÍ ÀJÀDÍ , ADÁGÚNODÒ EMMANUEL RÓTÌMÍ 
Published: November 2017

AbstractA diacritic is a mark placed near or through a character to alter its original phonetic or orthographic value. Many languages around the world use diacritics in their orthography, whatever the writing system the orthography is based on. In many languages, diacritics are ignored either by convention or as a matter of convenience. For users who are not familiar with the text domain, the absence of diacritics within text has been known to cause mild to serious readability and comprehension problems. However, the absence of diacritics in text causes near-intractable problems for natural language processing systems. This situation has led to extensive research on diacritization. Several techniques have been applied to address diacritic restoration (or diacritization) but the existing surveys of techniques have been restricted to some languages and hence left gaps for practitioners to fill. Our survey examined diacritization from the angle of resources deployed and various formulation employed for diacritization. It was concluded by recommending that (a) any proposed technique for diacritization should consider the language features and the purpose served by diacritics, (b) that evaluation metrics needed to be more rigorously defined for easy comparison of performance of models.
Goal Setting Deficits at 13 Years in Very Preterm Born Children
Authors: Haebich Kristina M. , Willmott Catherine , Ellis Rachel , Burnett Alice C. , Scratch Shannon E. , Pascoe Leona , Spencer-Smith Megan M. , Cheong Jeanie L.Y. , Inder Terrie E. , Doyle Lex W. , Thompson Deanne K. , Anderson Peter J. 
Published: November 2017

AbstractObjectives:Preterm children demonstrate deficits in executive functions including inhibition, working memory, and cognitive flexibility; however, their goal setting abilities (planning, organization, strategic reasoning) remain unclear. This study compared goal setting abilities between very preterm (VP: <30 weeks/<1250 grams) and term born controls during late childhood. Additionally, early risk factors (neonatal brain abnormalities, medical complications, and sex) were examined in relationship to goal setting outcomes within the VP group.Methods:Participants included 177 VP and 61 full-term born control children aged 13 years. Goal setting was assessed using several measures of planning, organization, and strategic reasoning. Parents also completed the Behavior Rating Inventory of Executive Function. Regression models were performed to compare groups, with secondary analyses adjusting for potential confounders (sex and social risk), and excluding children with major neurosensory impairment and/or IQ<70. Within the VP group, regression models were performed to examine the relationship between brain abnormalities, medical complications, and sex, on goal setting scores.Results:The VP group demonstrated a clear pattern of impairment and inefficiency across goal setting measures, consistent with parental report, compared with their full-term born peers. Within the VP group, moderate/severe brain abnormalities on neonatal MRI predicted adverse goal setting outcomes at 13.Conclusions:Goal setting difficulties are a significant area of concern in VP children during late childhood. These difficulties are associated with neonatal brain abnormalities, and are likely to have functional consequences academically, socially and vocationally. (JINS, 2018,24, 372–381)
Surveillance of the armed forces as a sentinel system for detecting adverse effects of dietary supplements in the general population
Authors: Lieberman Harris R , Austin Krista G , Farina Emily K 
Published: November 2017

AbstractObjectiveHalf the US population takes dietary supplements, but surveillance systems available to regulatory and public health authorities to determine whether specific dietary supplements present a risk are inadequate and numerous severe injuries and deaths have occurred from their consumption. Uniformed military personnel regularly use dietary supplements and are more likely to use potentially dangerous supplements than civilians. Recently, the supplement 1,3-dimethylamylamine (DMAA) was marketed for physical performance-enhancement and weight loss. However, after over 100 reports of illness attributed to DMAA, including six deaths, the Food and Drug Administration issued a warning to cease its sale.DesignWhen DMAA was legal (2010–2011), we conducted, using convenience samples, supplement surveys of service members and determined prevalence of use and self-reported symptoms of DMAA use.SubjectsWe surveyed 4374 armed forces personnel using a standardized dietary supplement survey administered by local health-care professionals.ResultsOverall, 11 % of survey respondents used dietary supplements labelled as containing DMAA at least once/week. Regular users were over two times more likely to report tachycardia (P<0·0001), tremors (P<0·0001) and dizziness (P=0·0004), and over three times more likely to report numbness/tingling (P<0·0001) than non-users.ConclusionsMilitary services could readily monitor adverse events associated with dietary supplements using electronic surveys and medical records. Since armed forces personnel are much more likely than civilians to use potentially dangerous dietary supplements like DMAA, near real-time surveillance of them using electronic surveys and medical records would provide early warning to regulatory agencies and the medical and public health communities when high-risk dietary supplements are introduced.
UNDER SIEGE IN ANY ERA
Authors: Lavelle Kristen M. 
Published: November 2017

AbstractWhites’ sense of their racial vulnerability has been established as a key facet of U.S. post-civil rights racial ideology. This paper analyzes Whites’ victim claims attached to a historical era, via recent in-depth interviews with elder White Southerners, and argues that, through invoking civil rights-era racial vulnerabilities—mistreatment from social changes and African Americans—White Southerners downplay institutional racism, delegitimize the Civil Rights Movement, and construct White innocence and Black pathology. In contrast, younger Whites’ victim claims assert Whites as racially innocent and equitably vulnerable to racism, but these narratives of the racial past achieve similar ends. By constructing the civil rights era as dangerous and unjust, elder White Southerners lay claim to a lifelong nonracist identity and deny systemic racism. This analysis suggests that White threat and victim narratives are not products of a post-civil rights milieu, but rather are generated by Whites’ use of racial framing to construct a sense of self, other, and society.
Who Cooperates? Reciprocity and the Causal Effect of Expected Cooperation in Representative Samples
Authors: Bechtel Michael M. , Scheve Kenneth F. 
Published: November 2017

AbstractWhen do societies succeed in providing public goods? Previous research suggests that public goods contributions correlate with expectations about cooperation by others among students and other demographic subgroups. However, we lack knowledge about whether the effect of expected cooperation is causal and a general feature of populations. We fielded representative surveys (N= 8,500) in France, Germany, the United Kingdom, and the United States that included a public goods game and a novel between-subjects experiment. The experiment varied expectations about cooperation by others. We find that higher expected cooperation by others causes a significant increase in individual contributions. When classifying contribution schedules, we find that almost 50% of the population employs a conditionally cooperative strategy. These individuals are on average richer, younger, and more educated. Our results help explain the varying success of societal groups in overcoming cooperation problems and assist policymakers in the design of institutions meant to solve social dilemmas.
Integrated sources of photon quantum states based on nonlinear optics
Authors: Caspani Lucia , Xiong Chunle , Eggleton Benjamin J , Bajoni Daniele , Liscidini Marco , Galli Matteo , Morandotti Roberto , Moss David J 
Published: November 2017

AbstractThe ability to generate complex optical photon states involving entanglement between multiple optical modes is not only critical to advancing our understanding of quantum mechanics but will play a key role in generating many applications in quantum technologies. These include quantum communications, computation, imaging, microscopy and many other novel technologies that are constantly being proposed. However, approaches to generating parallel multiple, customisable bi- and multi-entangled quantum bits (qubits) on a chip are still in the early stages of development. Here, we review recent advances in the realisation of integrated sources of photonic quantum states, focusing on approaches based on nonlinear optics that are compatible with contemporary optical fibre telecommunications and quantum memory platforms as well as with chip-scale semiconductor technology. These new and exciting platforms hold the promise of compact, low-cost, scalable and practical implementations of sources for the generation and manipulation of complex quantum optical states on a chip, which will play a major role in bringing quantum technologies out of the laboratory and into the real world.
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
Authors: Tan Joanne , Cognetta III Armand B. , Diaz Diego B. , Lum Kenneth M. , Adachi Shinya , Kundu Soumajit , Cravatt Benjamin F. , Yudin Andrei K. 
Published: November 2017

AbstractHeteroatom-rich organoboron compounds have attracted attention as modulators of enzyme function. Driven by the unmet need to develop chemoselective access to boron chemotypes, we report herein the synthesis of α- and β-aminocyano(MIDA)boronates from borylated carbonyl compounds. Activity-based protein profiling of the resulting β-aminoboronic acids furnishes selective and cell-active inhibitors of the (ox)lipid-metabolizing enzyme α/β-hydrolase domain 3 (ABHD3). The most potent compound displays nanomolar in vitro and in situ IC50 values and fully inhibits ABHD3 activity in human cells with no detectable cross-reactivity against other serine hydrolases. These findings demonstrate that synthetic methods that enhance the heteroatom diversity of boron-containing molecules within a limited set of scaffolds accelerate the discovery of chemical probes of human enzymes.
Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
Authors: Zhu Liang , Yang Jun , Bromberger Thomas , Holly Ashley , Lu Fan , Liu Huan , Sun Kevin , Klapproth Sarah , Hirbawi Jamila , Byzova Tatiana V. , Plow Edward F. , Moser Markus , Qin Jun 
Published: November 2017

AbstractActivation of transmembrane receptor integrin by talin is essential for inducing cell adhesion. However, the pathway that recruits talin to the membrane, which critically controls talin’s action, remains elusive. Membrane-anchored mammalian small GTPase Rap1 is known to bind talin-F0 domain but the binding was shown to be weak and thus hardly studied. Here we show structurally that talin-F0 binds to human Rap1b like canonical Rap1 effectors despite little sequence homology, and disruption of the binding strongly impairs integrin activation, cell adhesion, and cell spreading. Furthermore, while being weak in conventional binary binding conditions, the Rap1b/talin interaction becomes strong upon attachment of activated Rap1b to vesicular membranes that mimic the agonist-induced microenvironment. These data identify a crucial Rap1-mediated membrane-targeting mechanism for talin to activate integrin. They further broadly caution the analyses of weak protein–protein interactions that may be pivotal for function but neglected in the absence of specific cellular microenvironments.
Plasma cell survival in the absence of B cell memory
Authors: Hammarlund Erika , Thomas Archana , Amanna Ian J. , Holden Lindsay A. , Slayden Ov D. , Park Byung , Gao Lina , Slifka Mark K. 
Published: November 2017

AbstractPre-existing serum antibodies play an important role in vaccine-mediated protection against infection but the underlying mechanisms of immune memory are unclear. Clinical studies indicate that antigen-specific antibody responses can be maintained for many years, leading to theories that reactivation/differentiation of memory B cells into plasma cells is required to sustain long-term antibody production. Here, we present a decade-long study in which we demonstrate site-specific survival of bone marrow-derived plasma cells and durable antibody responses to multiple virus and vaccine antigens in rhesus macaques for years after sustained memory B cell depletion. Moreover, BrdU+cells with plasma cell morphology can be detected for 10 years after vaccination/BrdU administration, indicating that plasma cells may persist for a prolonged period of time in the absence of cell division. On the basis of these results, long-lived plasma cells represent a key cell population responsible for long-term antibody production and serological memory.
Transformation of the head-direction signal into a spatial code
Authors: Peyrache Adrien , Schieferstein Natalie , Buzsáki Gyorgy 
Published: November 2017

AbstractAnimals integrate multiple sensory inputs to successfully navigate in their environments. Head direction (HD), boundary vector, grid and place cells in the entorhinal-hippocampal network form the brain’s navigational system that allows to identify the animal’s current location, but how the functions of these specialized neuron types are acquired remain to be understood. Here we report that activity of HD neurons is influenced by the ambulatory constraints imposed upon the animal by the boundaries of the explored environment, leading to spurious spatial information. However, in the post-subiculum, the main cortical stage of HD signal processing, HD neurons convey true spatial information in the form of border modulated activity through the integration of additional sensory modalities relative to egocentric position, unlike their driving thalamic inputs. These findings demonstrate how the combination of HD and egocentric information can be transduced into a spatial code.
Microbial volatile communication in human organotypic lung models
Authors: Barkal Layla J. , Procknow Clare L. , Álvarez-García Yasmín R. , Niu Mengyao , Jiménez-Torres José A. , Brockman-Schneider Rebecca A. , Gern James E. , Denlinger Loren C. , Theberge Ashleigh B. , Keller Nancy P. , Berthier Erwin , Beebe David J. 
Published: November 2017

AbstractWe inhale respiratory pathogens continuously, and the subsequent signaling events between host and microbe are complex, ultimately resulting in clearance of the microbe, stable colonization of the host, or active disease. Traditional in vitro methods are ill-equipped to study these critical events in the context of the lung microenvironment. Here we introduce a microscale organotypic model of the human bronchiole for studying pulmonary infection. By leveraging microscale techniques, the model is designed to approximate the structure of the human bronchiole, containing airway, vascular, and extracellular matrix compartments. To complement direct infection of the organotypic bronchiole, we present a clickable extension that facilitates volatile compound communication between microbial populations and the host model. Using Aspergillus fumigatus, a respiratory pathogen, we characterize the inflammatory response of the organotypic bronchiole to infection. Finally, we demonstrate multikingdom, volatile-mediated communication between the organotypic bronchiole and cultures of Aspergillus fumigatus and Pseudomonas aeruginosa.
Virtual screening of inorganic materials synthesis parameters with deep learning
Authors: Kim Edward , Huang Kevin , Jegelka Stefanie , Olivetti Elsa 
Published: November 2017

AbstractVirtual materials screening approaches have proliferated in the past decade, driven by rapid advances in first-principles computational techniques, and machine-learning algorithms. By comparison, computationally driven materials synthesis screening is still in its infancy, and is mired by the challenges of data sparsity and data scarcity: Synthesis routes exist in a sparse, high-dimensional parameter space that is difficult to optimize over directly, and, for some materials of interest, only scarce volumes of literature-reported syntheses are available. In this article, we present a framework for suggesting quantitative synthesis parameters and potential driving factors for synthesis outcomes. We use a variational autoencoder to compress sparse synthesis representations into a lower dimensional space, which is found to improve the performance of machine-learning tasks. To realize this screening framework even in cases where there are few literature data, we devise a novel data augmentation methodology that incorporates literature synthesis data from related materials systems. We apply this variational autoencoder framework to generate potential SrTiO3 synthesis parameter sets, propose driving factors for brookite TiO2 formation, and identify correlations between alkali-ion intercalation and MnO2 polymorph selection.
Direct evidence of multichannel-improved charge-carrier mechanism for enhanced photocatalytic H2 evolution
Authors: Zhao Jiangtao , Zhang Peng , Wang Zhuo , Zhang Shijie , Gao Hongqing , Hu Junhua , Shao Guosheng 
Published: November 2017

AbstractIn the field of photocatalysis, the high-charge recombination rate has been the big challenge to photocatalytic conversion efficiency. Here we demonstrate the direct evidence of multichannel-improved charge-carrier mechanism to facilitate electron-hole transfer for raising photocatalytic H2 evolution activity. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and UV-Vis diffuse reflectance spectroscopy (DRS), were used to characterize the as-fabricated samples. The result shows that the present design of Au/Pt nanoparticles (NPs) decorated one-dimensional Z-scheme TiO2/WO3 heterostructure composite nanofibers have been fabricated, which even exhibited excellent light absorption in the visible region and greatly enhanced photocatalytic activities on H2 generation comparing with pure TiO2, TiO2/WO3 and Pt/WO3/TiO2 nanofibers. This greatpromotion is mainly on account of the photosynthetic heterojunction system, which include the surface plasmon resonance (SPR) of Au nanoparticles, low overpotential of Pt nanoparticles, and more importantly, the one-dimensional multichannel-improved charge-carrier photosynthetic heterojunction system with Pt as an electron collector and WO3 as a hole collector. Transferring photoinduced electrons and holes at the same time, leading to effective charge separation was directly proved by ultraviolet photoelectron spectroscopy, electrochemical impedance spectroscopy, photocurrent analysis and incident photon-to-electron conversion spectrum.
Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis
Authors: Cosenza Stella , Ruiz Maxime , Toupet Karine , Jorgensen Christian , Noël Danièle 
Published: November 2017

AbstractMesenchymal stem or stromal cells (MSCs) exert chondroprotective effects in preclinical models of osteoarthritis (OA). Most of their therapeutic effects are mediated via soluble mediators, which can be conveyed within extracellular vesicles (EVs). The objective of the study was to compare the respective role of exosomes (Exos) or microvesicles/microparticles (MPs) in OA. MPs and Exos were isolated from bone marrow murine BM-MSCs through differential centrifugation. Effect of MPs or Exos was evaluated on OA-like murine chondrocytes and chondroprotection was quantified by RT-qPCR. In OA-like chondrocytes, BM-MSC-derived MPs and Exos could reinduce the expression of chondrocyte markers (type II collagen, aggrecan) while inhibiting catabolic (MMP-13, ADAMTS5) and inflammatory (iNOS) markers. Exos and MPs were also shown to protect chondrocytes from apoptosis and to inhibit macrophage activation. In vivo, Exos or MPs were injected in the collagenase-induced OA (CIOA) model and histomorphometric analyses of joints were performed by µCT and confocal laser microscopy. BM-MSCs, MPs and Exos equally protected mice from joint damage. In conclusion, MPs and Exos exerted similar chondroprotective and anti-inflammatory function in vitro and protected mice from developing OA in vivo, suggesting that either Exos or MPs reproduced the main therapeutic effect of BM-MSCs.