bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ti- Mn based Bimetallic Alloy Electrocatalyst for Improve Hydrogen Evolution Reaction
Authors: Jain Riya , Raj Ritu , Ram Mange , Rani Anju , Dhayal Rajendra , Haldar Krishna 
Published: October 2024

Abstract

Developing electrocatalysts that are highly efficient and durable is essential for creating high-performance water-splitting devices, which are crucial for clean energy conversion. Unfortunately, existing electrocatalysts are inefficient and necessitate high overvoltage to facilitate the water-splitting reactions effectively. In this study, we are introducing a titanium-manganese alloy as a promising catalyst for the hydrogen evolution reaction (HER). We evaluated the electrocatalytic activity of the TiMn2 alloy for the production of hydrogen in acidic electrolytes. Our results demonstrate that the TiMn2 electrocatalyst exhibits a low overpotential of 139 mV for HER in 0.5 M H2SO4 and a low Tafel slope of 68 mV/dec at a current density of 10 mA/cm2 and a scan rate of 10 mV/s.In addition to this remarkable activity, the catalyst demonstrates excellent stability as a HER electrode over 24 hours of continuous operation, with minimal activity loss (13.2%).
Difference and connection of clinical features and antinuclear antibody patterns in new-onset Systemic Lupus Erythematosus cross age groups
Authors: Gong Muxue , Li Ning , Sun Chao , Hong Dengxiao , Wang Xin , Ye Ming , Wang Tao , Li Zhijun , Xie Changhao 
Published: October 2024

Abstract

To investigate the differences in clinical features, and the relationship between antinuclear antibody (ANA) patterns, autoantibodies, and symptoms among different age groups in new-onset Systemic Lupus Erythematosus (SLE), we conducted a retrospective cohort study involving 556 patients diagnosed with SLE. These patients were classified into three groups: Group 1: juvenile-onset SLE (< 18 years); Group 2: early-onset adult SLE (18-50 years); and Group 3: late-onset SLE (≥ 50 years). We utilized a clustering heatmap to identify variations and associations of autoantibodies among the groups. The Kruskal-Wallis test was performed to compare clinical feature across the groups. The correlation heatmap were used to analyze the relationship of ANA patterns with symptoms. We found late-onset SLE patients exhibited more severe kidney damage and a higher likelihood of infection. ;Late-onset patients with a speckled ANA pattern were more prone to developing Raynaud's phenomenon. It is important for early-onset adult SLE patients with a homogeneous ANA pattern to be vigilant about the possibility of renal disorders and skin involvement. It is the first Chinese JSLE, early-onset ASLE and late-onset SLE study for ANA patterns, which enrolled a large number of newly diagnosed patients. These novel findings contribute to the diagnosis and prevention of SLE.
Painful left bundle branch block after interventional treatment of right coronary artery stenosis：A case report and literature review
Authors: Zhao Zihan , Wang Ranran , Zhang Meijing , Sun Mingzhuang 
Published: October 2024

Abstract

Objective
To report the diagnosis and treatment process of a rare case of coronary atherosclerotic heart disease complicated with painful left bundle branch block.
Methods
A retrospective analysis was conducted on a patient admitted to the Aerospace Center Hospital in July 2023, whose primary symptom was recurrent angina. The diagnosis and treatment process, as well as its special features, were summarized and analyzed.
Results
The patient was an elderly male presenting primarily with angina. Coronary angiography revealed severe stenosis of the right coronary artery. After interventional treatment of the right coronary artery, the patient developed different characteristics of chest pain compared to previous episodes. Through dynamic electrocardiogram monitoring and treadmill exercise testing, he was ultimately diagnosed with Painful Left Bundle Branch Block Syndrome. Following the administration of oral beta-blockers, the patient's symptoms significantly improved during follow-up.
Conclusion
Painful Left Bundle Branch Block Syndrome commonly occurs in patients without coronary artery disease. However, it can be overlooked in some patients with concomitant coronary heart disease due to the presence of the primary condition. This case diagnosed coronary heart disease complicated by painful left bundle branch block syndrome, where intervention on the right coronary artery may serve as a triggering factor for exacerbating painful left bundle branch block syndrome. It is hoped that this case report will provide new insights for future clinical diagnosis and treatment related to this condition.
Enhancing Disaster Surge Capacity Through Reverse Triage in Addis Ababa Hospitals: a Cross-sectional Study
Authors: Seyoum Tsion , Adal Ousman , Beza Lemlem , Bell Sue Anne , Azazh Aklilu 
Published: October 2024

Abstract

Introduction:During disasters and emergencies, hospitals are pivotal in response efforts, particularly through the early discharge of inpatients who can be safely released to free up capacity. Reverse triage helps hospitals efficiently allocate resources and prioritize patient care based on medical necessity.
Objective: This study investigates the impact of reverse triage on surge capacity in public hospitals in Addis Ababa, Ethiopia, during disaster scenarios.
Methods: This cross-sectional study was conducted in three public hospitals using convenience sampling. Data were collected from September 1 to 30, 2023. Descriptive statistics and binomial logistic regression were used to identify factors associated with hospital surge capacity.
Results: A total of 296 participants were included, with 45.9% aged 13-34 years and 55% female. Of the participants, 69.3% were admitted through the Emergency Department. The Reverse Triage Tool Leuven was used to assess patients for early discharge, with 58.4% (95% CI 52.6% -64.1%) of patients qualifying. The percentages of patients eligible for early discharge were approximately 66.7% (95% CI 54% - 77.8%) at Zewditu Memorial Hospital, 57.6% (95% CI 49.5% - 65.4%) at Tikur Anbessa Specialized Hospital (TASH), and 52.8% (95% CI 40.7% - 64.7%) at St. Paul Hospital Millennial Medical College.
Conclusion: The study underscores the effectiveness of reverse triage in identifying patients suitable for early discharge during disasters, thereby enhancing surge capacity and resource management in public hospitals.
Semaglutide Reverses the Chronic Myopathy of Hyperkalemic Periodic Paralysis: A Case Report
Authors: Brand Kenneth , Landry Daniel , Mulhern Jeffrey , Braden Gregory 
Published: October 2024

Abstract

Background: Hyperkalemic Periodic Paralysis (HPP) is an autosomal dominant genetic disorder where high extracellular potassium depolarizes skeletal muscle and triggers painful sustained contractions that lead to permanent myopathy. Interventions have typically relied on acetazolamide and diclofenamide with limited success.
Case Presentation: The patient is a 48 year old man with HPP from a familial autosomal dominant sodium channel point mutation in the SCN4A gene at position 704 with symptoms starting in early childhood. By age 30 he developed permanent muscle weakness and no intervention had improved his myopathy.
In the spring of 2023, semaglutide was initiated for weight loss. Before the semaglutide he could not rise out of a chair without help and his gait was very slow. Over the next year his strength and quality of life returned to levels he had not had in decades.
Conclusion: This is the first effective treatment for HPP. By directly acting on skeletal muscle both dependent and independent of insulin, GLP-1s are an excellent and novel option that treat not just the hyperkalemic periodic paralysis but also the skeletal muscle atrophy in a multimodal way.
Prognostic value of G8 for functional decline and 1-year mortality in older patients with cancer: A multicenter prospective study
Authors: Sifón María del Rosario , Garrido María José Molina , Okassova Ainur , Recondo Gonzalo , Perazzo Florencia , Greco Martín , Mandó Pablo 
Published: October 2024

Abstract

Purpose
Geriatric 8 (G8) is a screening tool to identify frail older patients with cancer. Functional decline (FD) is a determinant in quality of life and survival. We aim to determine the predictive value of G8 for FD in patients with cancer after a new treatment, and its prognostic value for 1-year mortality, severe adverse events, and hospitalizations.
Methods
Prospective multicenter cohort study of patients ≥ 65 years old receiving oncologic treatment in two hospitals assessed with baseline G8. Cut-off value of G8: ≤14. Functional status was assessed using Instrumental Activities of Daily Living (IADL). Primary objective was FD, defined as a decrease of 1 point on IADL after two months of treatment.
Results
226 patients were included, 222 started treatments. After two months, IADL was available for 210; twelve patients (5,4%) died before second evaluation. 66.2% (147) presented an altered G8 score. In those with altered G8, 39.3% (53) had FD and in patients with normal G8, only 13.3% (10) (p < 0.001). At final analysis 222 were available for 1-year mortality and 37.8% (84) had died. After one year of treatment beginning, 48.3% (71) of those with altered G8 had died compared with 17.3% (13) of those with normal G8 (p = 0.001).
Conclusion
FD has an important prognostic value in older patients with cancer and this data shows a strong association of baseline G8 with FD and mortality; supporting the routine use of this tool in the management of older patients with cancer.
Case Report: A Case of Epstein Barr Virus-related Glial Fibrillary Acidic Protein Astrocytopathy Refractory to Conventional Immunotherapy
Authors: Ju Shaowen , Liu Yixue , Zhang Tingfang , Song Donglei , Heng Dongyang , Zhang Wenli 
Published: October 2024

Abstract

Background
Epstein-Barr virus (EBV) infection has been associated with the development of glial fibrillary acidic protein astrocytopathy (GFAP-A), with most cases responding favorably to steroids and/or intravenous immunoglobulin (IVIG). We report a case of EBV-related GFAP-A exhibiting a poor response to conventional immunotherapy.
Case presentation
A 62-year-old Chinese male presented with dysuria, fever, and headache, rapidly progressing to paraparesis. Initial investigations indicated pulmonary infection and viral encephalitis. Despite intensive care and antiviral treatment, his condition deteriorated, necessitating tracheostomy and intubation. Upon transfer to a tertiary neurology center, he had reduced tone, power, and areflexia in the lower limbs, and a loss of sensation below the T6 level. Cerebrospinal fluid (CSF) analysis revealed markedly elevated cell counts and protein levels. MRI showed leptomeningeal enhancement in the left frontal lobe, cervical and thoracic spines. EBV DNA and GFAP-IgG were detected in the CSF, suggesting a diagnosis of EBV-related GFAP-A. Treatment with IV acyclovir, high-dose steroids, and IVIG was administered with no clinical improvement.
Conclusions
This report presents a case of EBV-related GFAP-A refractory to treatments with steroids and IVIG. It suggests that higher levels of CSF protein and cell count may predict worse outcomes and a poorer prognosis.
ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid Leukemia
Authors: Wurm Alexander , Schäfer Silvia , Schmitz-Hübsch Lola , Shaikh Mehak , Brilloff Silke , Rahimian Elahe , Kufrin Vida , Küchler Sandra , Fedorova Maria , Kusebauch Natalie , Ni Zhixu , Helm Dominic , Schewe Denis , Ball Claudia , Bornhaeuser Martin , Glimm Hanno , Alberich-Jorda Meritxell , Bill Marius 
Published: October 2024

Abstract

Deregulation of lipid metabolism has been shown to be involved in leukemogenesis and disease progression of acute myeloid leukemia (AML), yet vulnerabilities within the lipidome remain largely unexplored. Through comprehensive analysis of CRISPR-Cas9 screening data, we identified a specific dependency of a subset of AML cell lines on the gene acyl-CoA synthetase long chain family member 4 (ACSL4). Particularly those AML cell lines with chromosomal rearrangements involving the gene lysine methyltransferase 2A (KMT2A) showed an increased dependency on ACSL4. Using CRISPR interference (CRISPRi)- and shRNA-mediated knockdown of ACSL4 in both KMT2A-rearranged (KMT2Ar) and non-KMT2Ar AML cells, we confirmed the dependency of KMT2Ar AML on ACSL4. The knockdown of Acsl4 in a KMT2Ar mouse model resulted in reduced colony-forming capacity ex vivo and signiﬁcantly delayed leukemia onset in vivo. To understand molecular differences between ACSL4-dependent and non-dependent AML cells upon ACSL4 knockdown, we performed a multi-omics approach, including transcriptomics, proteomics, and lipidomics. Integration of these data revealed an upregulation of lipid metabolism pathways exclusively in ACSL4-dependent cell lines. We generated a 12 gene-containing KMT2Ar-ACSL4 dependency signature (KRADS12) and confirmed its association with KMT2Ar and survival in AML patients. Collectively, our findings highlight an unknown vulnerability in the aggressive KMT2Ar AML subtype.
The effect of Orem’s theory of interventional education on self-care, worry and health practices of pregnant women aged 35 years or above, referring to health service centers in Gonabad county, 2024
Authors: Kheibari Zahra Hasannia , Mohammadzadeh Fatemeh , Bahri Narjes , Askari Fariba 
Published: October 2024

Abstract

Background:Self-care during pregnancy requires special attention, particularly among women aged 35 and above. This study aimed to determine the impact of an educational intervention based on the Orem theory on self-care, worry, and health practices among pregnant women aged 35 and older referred to comprehensive health service centers in Gonabad County.
Methods: This randomized controlled trial was conducted in 2023 among 53 pregnant women aged 35 and above referred to comprehensive health service centers in Gonabad County. Participants were randomly assigned to the intervention or control group. Data was collected using questionnaires on demographic and obstetric characteristics, the Cambridge worry Scale, Hart's prenatal care actions, and Health Practices in Pregnancy Questionnaire-II. The intervention group received a theory-based educational intervention in three sessions, while the control group received no intervention. Research staff completed questionnaires before, immediately, and one month after the intervention. Data analysis was performed using generalized estimating equations (GEE) with a significance level 0.05.
Results: Based on the GEE model, there were no statistically significant differences in mean scores for self-care, health practices, and worry between the two groups prior to the intervention (p > 0.05). Post-intervention, both groups exhibited an increase in mean scores for self-care and health practices, but the intervention group demonstrated a steeper increase, which was statistically significant. In contrast, the intervention group experienced a more pronounced decrease in mean worry scores than the control group (p < 0.05).
Conclusion: The findings suggest that a self-care educational program based on the Orem's theory can be effective in enhancing self-care and health practices and reducing worry among pregnant women. Therefore, it is recommended that this educational program be implemented for pregnant women aged 35 and above.
Trial registration and ethics code: IRCT registration number: IRCT20231107059980N1 and ethics code: IR.GMU.REC.1402.
Registration date: 30/11/2023
Study on the Correlation Between Physical Activity During Pregnancy and Delivery Mode in Nulliparous Patients：A prospective cohort study
Authors: Ren Shu-Qun , Zhang Xiao-Ming , Zhao Qian , Li Lei-E 
Published: October 2024

Abstract

BACKGROUND: Physical activity during pregnancy is a beneficial behavioral intervention aimed at enhancing pregnancy outcomes. Nevertheless, the association between prenatal physical activity and mode of delivery remains contentious. This study seeks to investigate whether physical activity during pregnancy correlates with the mode of delivery, with the ultimate objective of bolstering pregnant women's self-efficacy regarding physical activity and ameliorating pregnancy outcomes.
OBJECTIVE: This study aims to test the hypothesis that physical activity during pregnancy is associated with a reduced risk of cesarean delivery.
STUDY DESIGN: This prospective cohort study surveyed women with singleton pregnancies, free from contraindications to physical activity, utilizing the Chinese version of the Pregnancy Physical Activity Questionnaire. This instrument categorizes and quantifies physical activity by type and intensity. The primary outcome of interest is the mode of delivery. Univariate and multivariate binary logistic regression models were employed to ascertain the relationship between prenatal physical activity and mode of delivery.
RESULTS: A total of 217 women participated in the physical activity survey during pregnancy and subsequently gave birth at our hospital. The median energy expenditure from physical activity during pregnancy was 145.70 (111.92, 181.69) MET-h·wk⁻¹. The mean age of the participants was 30.20±3.71 years. Among the 217 primiparas, 131 experienced vaginal deliveries, while 86 underwent cesarean sections. After comprehensive adjustment for covariates, the risk of cesarean delivery was found to be reduced by 60% in the group that adhered to the recommended levels of physical activity during pregnancy compared to the group that did not (OR: 0.40, 95% CI: 0.20 to 0.83, P=0.0130).
CONCLUSION: Elevated levels of physical activity during pregnancy are associated with a reduced risk of cesarean delivery. Physical activity need not be confined to structured exercise programs; routine activities such as cleaning, shopping, and commuting on foot are effective means of increasing energy expenditure and achieving recommended physical activity levels.
Atrial Fibrillation Is Associated with Increased In-Hospitality Mortality During Chimeric Antigen Receptor T-cell Therapy Hospitalizations: A Retrospective Cohort Study in the United States.
Authors: Baral Nischit , Karki Nabin R. , Ladin Daniel A. , Zaghlol Raja , Ibrahim Mahmoud , Rabadi Alexander , Elajami Tarec K. , Mechanic Olivia , Kunadi Arvind , Mitchell Joshua D. 
Published: October 2024

Abstract

Background: Chimeric Antigen Receptor (CAR) T-cell therapy (CAR-T) has emerged as a promising treatment for specific hematological malignancies. While some studies suggest an association between CAR-T and atrial fibrillation (AF), more data are needed on the impact of AF on CAR-T outcomes.
Methods: This retrospective cohort study utilized the National Inpatient Sample (NIS) 2017-2020 to explore in-hospital outcomes in cancer patients with AF while undergoing CAR-T. Comparisons were drawn between patients with and without AF (occurring at any time), assessing various parameters including mortality rates, length of hospital-stay, and occurrences of acute heart failure, pulmonary edema, and gastrointestinal (GI) bleeding.
Results: Of the 236,270 cancer-related hospitalizations, 1,030 cases (0.44%) received CAR-T. The average age of CAR-T recipients was 55.6 years ±18.1 years, and females constituted 40.5% of the total CAR-T recipients. Of the 1030 patients receiving CAR-T, 97 (9.4%) had an associated diagnosis of AF (occurring at any time) during their hospitalization. A multivariable logistic regression analysis, adjusted for age, sex, race, comorbidity, and income, revealed that cancer hospitalizations who underwent CAR-T therapy with AF had increased odds of in-hospital mortality (adjusted odds ratio, aOR: 3.87), acute pulmonary edema (aOR: 3.29), GI bleeding (aOR: 5.46), acute heart failure (aOR: 10.2), and extended hospital stays (Beta coefficient: 0.18) compared to hospitalizations with CAR-T but without AF. Similar results were seen in a sensitivity analysis limited to diffuse large B cell lymphoma patients receiving CAR-T.
Conclusions: In cancer patients receiving CAR-T, AF is independently associated with a higher risk of in-hospital mortality, acute pulmonary edema, gastrointestinal bleeding, acute heart failure, and prolonged hospitalization.
A relatively accurate prediction model for the risk of developing mild cognitive impairment in patients with sarcopenia: Evidence from the CHARLS
Authors: Liu Xinyue , Ni Jingyi , Wang Baicheng , Yin Rui , Tang Jinlin , Chu Qi , You Lianghui , Wu Zhenggang , Cao Yan , Ji Chenbo 
Published: October 2024

Abstract

Background
Sarcopenia significantly raises the risk of cognitive impairments in older adults. Early warning of mild cognitive impairment (MCI) in those with sarcopenia is crucial for timely intervention.
Aims
To construct an accurate prediction model for screening MCI in sarcopenia population.
Methods
We combined machine learning and deep learning techniques to analyze data from 597 sarcopenia patients in the China Health and Retirement Longitudinal Study (CHARLS). Our model predicts MCI incidence over the next four years, categorizing patients into low, intermediate, and high-risk groups based on their risk levels.
Results
The model was constructed using CHARLS data from 2011–2015 and included seven validated variables. It performed superior to logistic regression, achieving an Area Under the Curve (AUC) of 0.808 (95% CI: 0.704–0.899) for the test set and accurately classifying patients' risk in the training set. The deep learning model demonstrated a low false-positive rate of 1.63% for MCI in higher-risk groups. Independent validation using 2015–2018 CHARLS data confirmed the model’s efficacy, with an AUC of 0.76 (95% CI: 0.67–0.83). A convenient online tool to implement the model was developed at http://47.115.214.16:5000/.
Conclusions
This deep learning model effectively predicts MCI risk in sarcopenia patients, supporting early interventions. Its accuracy helps identify high-risk individuals, potentially improving patient care.