bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unrelated matched versus autologous transplantation in adult patients with good and intermediate risk acute myelogenous leukemia in first molecular remission
Authors: Gorin Norbert‐Claude , Labopin Myriam , Pabst Thomas , Remenyi Peter , Wu Depei , Huynh Anne , Volin Liisa , Cahn Jean Yves , Yakoub‐Agha Ibrahim , Mercier Melanie , Houhou Mohamed , Mohty Mohamad , Nagler Arnon ,   on behalf of the Acute Leukemia Working Party of the EBMT
Published: September 2017

AbstractPatients with Acute Myelogenous Leukemia have a better outcome if reaching molecular remission. We compared the outcome of 373 patients autografted and 335 patients allografted with a 10/10 compatible unrelated donor in first molecular remission. Patients were stratified using the ELN European Leukemia Net classification. ELN favorable group: (234 auto and 70 unrelated transplants). By univariate analysis, in the auto group, the Non Relapse Mortality (NRM) was lower (3.7% versus 19%; P < 10−4), Relapse Incidence (RI) higher (29% versus 17%, P < 10−4), Leukemia Free Survival (LFS) identical (67% versus 64%) and Overall Survival (OS) better than in the allogeneic group (83% versus 62%; P = .008). By multivariate analysis, autologous transplantation was associated with a lower NRM (HR: 4, P = .01) and a better OS (HR: 2.08, P = .04). ELN intermediate group 1: (87 autologous and 172 unrelated transplants). By univariate analysis, in the auto group, NRM was lower (2.5% versus 11.8%; P = .03), RI higher (59% versus 18%, P < 10−6), LFS lower (39% versus 70%; P < 10−6) and OS lower than in the unrelated donor group (61% versus 74%; P = .005). By multivariate analysis, unrelated donor was superior to autologous transplantation for LFS (HR: 0.36, P < 10−5) and OS (HR: 0.53, P = .01). ELN intermediate group 2: (52 autologous and 93 unrelated donors). The outcome was identical. We conclude that good risk patients get higher benefit from autologous transplantation. Intermediate risk 2 patients have the same outcome and Intermediate risk 1 patients get higher benefit from unrelated donor transplants.
Estimating activity of Japanese macaques (Macaca fuscata) using accelerometers
Authors: Sha John C. M. , Kaneko Akihisa , Suda‐Hashimoto Naoko , He Tianmeng , Take Makiko , Peng Zhang , Hanya Goro 
Published: September 2017

AbstractAccelerometers have been used to study both terrestrial and aquatic wildlife, mainly for mammal and bird species. In terrestrial mammals, there is a bias toward ungulates and carnivores, with fewer studies on nonhuman primates. In this study, we tested the use of accelerometers for studying the activity of Japanese macaques (Macaca fuscata). We modeled the activity of a male and a female subject by matching continuous focal observations from video recordings to sensor parameters derived from collar‐mounted accelerometers. Models achieved classification performance (AUC) of greater than 90% for both subjects, with similar results when subjects were cross‐validated. Accelerometer‐based estimates of activity had comparable accuracies to estimates from instantaneous sampling at 1 min and 5 min intervals. We further demonstrated the use of model estimates for analyzing circadian rhythm and night time activity of M. fuscata. Our results add support to the feasibility of using accelerometers for studying activity of nonhuman primates. We discussed the limitations, benefits and potential applications of remote‐sensing technology like accelerometers for advancing primalotogical studies.
Mutations of KIF14 cause primary microcephaly by impairing cytokinesis
Authors: Moawia Abubakar , Shaheen Ranad , Rasool Sajida , Waseem Syeda Seema , Ewida Nour , Budde Birgit , Kawalia Amit , Motameny Susanne , Khan Kamal , Fatima Ambrin , Jameel Muhammad , Ullah Farid , Akram Talia , Ali Zafar , Abdullah Uzma , Irshad Saba , Höhne Wolfgang , Noegel Angelika Anna , Al‐Owain Mohammed , Hörtnagel Konstanze , Stöbe Petra , Baig Shahid Mahmood , Nürnberg Peter , Alkuraya Fowzan Sami , Hahn Andreas , Hussain Muhammad Sajid 
Published: September 2017

ObjectiveAutosomal recessive primary microcephaly (MCPH) is a rare condition characterized by a reduced cerebral cortex accompanied with intellectual disability. Mutations in 17 genes have been shown to cause this phenotype. Recently, mutations in CIT, encoding CRIK (citron rho‐interacting kinase)—a component of the central spindle matrix—were added. We aimed at identifying novel MCPH‐associated genes and exploring their functional role in pathogenesis.MethodsLinkage analysis and whole exome sequencing were performed in consanguineous and nonconsanguineous MCPH families to identify disease‐causing variants. Functional consequences were investigated by RNA studies and on the cellular level using immunofluorescence and microscopy.ResultsWe identified homozygous mutations in KIF14 (NM_014875.2;c.263T>A;pLeu88*, c.2480_2482delTTG; p.Val827del, and c.4071G>A;p.Gln1357=) as the likely cause in 3 MCPH families. Furthermore, in a patient presenting with a severe form of primary microcephaly and short stature, we identified compound heterozygous missense mutations in KIF14 (NM_014875.2;c.2545C>G;p.His849Asp and c.3662G>T;p.Gly1221Val). Three of the 5 identified mutations impaired splicing, and 2 resulted in a truncated protein. Intriguingly, Kif14 knockout mice also showed primary microcephaly. Human kinesin‐like protein KIF14, a microtubule motor protein, localizes at the midbody to finalize cytokinesis by interacting with CRIK. We found impaired localization of both KIF14 and CRIK at the midbody in patient‐derived fibroblasts. Furthermore, we observed a large number of binucleated and apoptotic cells—signs of failed cytokinesis that we also observed in experimentally KIF14‐depleted cells.InterpretationOur data corroborate the role of an impaired cytokinesis in the etiology of primary and syndromic microcephaly, as has been proposed by recent findings on CIT mutations. Ann Neurol 2017;82:562–577
One‐Step Multigram‐Scale Biomimetic Synthesis of Psiguadial B
Authors: Newton Christopher G. , Tran Duc N. , Wodrich Matthew D. , Cramer Nicolai 
Published: September 2017

AbstractA gram‐scale synthesis of psiguadial B, a purported inhibitor of human hepatoma cell growth, has been achieved in one step by a biomimetic three‐component coupling of caryophyllene, benzaldehyde, and diformylphloroglucinol. This cascade reaction is catalyzed by N,N′‐dimethylethylenediamine, and proceeds at ambient temperature to generate four stereocenters, two rings, one C−O bond, and three C−C bonds. Combined computational and experimental investigations suggest the biosynthesis of the natural product is non‐enzyme mediated, and is the result of a Michael addition between caryophyllene and a reactive ortho‐quinone methide, followed by two sequential intramolecular cationic cyclization events.
An Extensive Family of Heterometallic Titanium(IV)–Metal(III) Rings with Structure Control through Templates
Authors: Timco Grigore A. , Fernandez Antonio , Kostopoulos Andreas K. , Muryn Christopher A. , Pritchard Robin G. , Strashnov Ilya , Vitorica‐Yrezebal Inigo J. , Whitehead George F. S. , Winpenny Richard E. P. 
Published: September 2017

AbstractA family of heterometallic [Cat][TixMO(x+1)(O2CtBu)2x+2] rings is reported where Cat=a secondary or tertiary alkyl ammonium ion, x=7, 8 or 9, and M=FeIII, GaIII, CrIII, InIII and AlIII. The structures are regular polygons with eight, nine or ten vertices with each edge bridged by an oxide and two pivalates. The size of the ring formed is controlled by the alkylammonium cation present. In each case a homometallic by‐product is found [Cat][TixO(x+1)(O2CtBu)2x−1].
Reactivity of a Dihydrodiborene with CO: Coordination, Insertion, Cleavage, and Spontaneous Formation of a Cyclic Alkyne
Authors: Arrowsmith Merle , Böhnke Julian , Braunschweig Holger , Celik Mehmet Ali 
Published: September 2017

AbstractUnder a CO atmosphere, the dihydrodiborene [(cAAC)HB=BH(cAAC)] underwent coordination of CO concomitant with reversible hydrogen migration from boron to the carbene carbon atom, as well as reversible CO insertion into the B=B bond. Heating the CO adduct resulted in two unusual cAAC ring‐expansion products, one presenting a B=C bond to a six‐membered 1,2‐azaborinane‐3‐ylidene, the other an unprecedented nine‐membered cyclic alkyne resulting from reductive cleavage of CO and spontaneous formation of a C≡C bond.
Potential of producing carbon fiber from biorefinery corn stover lignin with high ash content
Authors: Qu Wangda , Liu Jing , Xue Yuan , Wang Xinwei , Bai Xianglan 
Published: September 2017

ABSTRACTThe possibility of producing carbon fiber from an industrial corn stover lignin was investigated in the present study. As‐received, high‐ash containing lignin was subjected to methanol fractionation, acetylation, and thermal treatment prior to melt spinning and the changes in physiochemical and thermal properties were evaluated. Methanol fractionation removed most of the impurities in the raw lignin and also selectively removed the molecules with high melting points. However, neither methanol fractionation nor thermal treatment rendered melt‐spinnable precursors. The precursors were highly viscous and decomposed easily at low temperatures, attributed to the presence of H, G phenolic units, and abundant hydroxycinnamate groups in herbaceous lignin. A two‐step acetylation of methanol fractionated lignin greatly improved the mobility of lignin, while enhancing the thermal stability of the precursor during melt‐spinning. Fourier Transform Infrared and 2D‐NMR analysis showed that the contents of phenolic and aliphatic hydroxyls, as well as the hydroxycinnamates, decreased in the acetylated precursors. The optimum precursor was a partially acetylated lignin with a glass transition temperature of 85 °C. Upon oxidative stabilization and carbonization, the carbon fibers with an average tensile strength of 454 MPa and modulus of 62 GPa were obtained. The Raman spectroscopy showed the ID/IG ratio of the carbon fiber was 2.53. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45736.
Preparation of antibacterial temperature‐sensitive silver‐nanocomposite hydrogels from N‐isopropylacrylamide with green tea
Authors: Jayaramudu Tippabattini , Varaprasad Kokkarachedu , Sadiku Emmanuel Rotimi , Kim Hyun Chan , Kim Jaehwan 
Published: September 2017

ABSTRACTThis article reports the temperature‐sensitive, green tea (GT)‐based silver‐nanocomposite hydrogels for bacterial growth inactivation. The temperature‐sensitive hydrogels were prepared via free‐radical polymerization using temperature‐sensitive N‐isopropylacrylamide (NIPAM) monomer with GT as the hydrogel matrix. The nanocomposite hydrogels were encapsulated with silver ions via swelling method, which was later reduced to silver nanoparticles using Azadirachta indica leaf extract. The temperature‐sensitive silver nanocomposite hydrogels were analyzed by using Fourier transforms infrared, UV–visible spectroscopy, differential scanning calorimetry–thermogravimetric analysis, X‐ray diffraction, scanning electron microscopy, and transmission electron microscopy. The prepared hydrogels exhibited higher phase volume transition temperature than the NIPAM. The inhibition zone study of the inactivation of bacteria on the developed hydrogels was carried out against Gram negative (Escherichia coli) and Gram positive (Staphylococcus aureus), which revealed that the prepared hydrogels are helpful for the inactivation of these bacteria due to the high stabilization of antibacterial properties of the silver nanoparticles. The developed hydrogels are promising for biomedical applications. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45739.
A grid refinement study of trade wind cumuli simulated by a Lagrangian cloud microphysical model: the super‐droplet method
Authors: Sato Yousuke , Shima Shin‐ichiro , Tomita Hirofumi 
Published: September 2017

AbstractThe impact of spatial resolution on the simulation of trade wind cumuli was investigated. The super‐droplet method, an efficient stochastic Lagrangian cloud microphysical model, was used to reduce uncertainties due to the empirical parameterisation of cloud microphysics and numerical diffusion for advection, which is inevitable in an Eulerian cloud microphysical model. We showed for the first time that cloud cover numerically converged with a grid resolution of 12.5 m. Our grid refinement analysis elucidated a significant contribution of small cumulus clouds to total cloud cover, as such cumuli are generated by small‐scale updrafts that can be resolved only at a fine resolution.
Inhibition analysis of inhibitors derived from lignocellulose pretreatment on the metabolic activity of Zymomonas mobilis biofilm and planktonic cells and the proteomic responses
Authors: Todhanakasem Tatsaporn , Yodsanga Supanika , Sowatad Apinya , Kanokratana Pattanop , Thanonkeo Pornthep , Champreda Verawat 
Published: September 2017

AbstractLignocellulose pretreatment produces various toxic inhibitors that affect microbial growth, metabolism, and fermentation. Zymomonas mobilis is an ethanologenic microbe that has been demonstrated to have potential to be used in lignocellulose biorefineries for bioethanol production. Z. mobilis biofilm has previously exhibited high potential to enhance ethanol production by presenting a higher viable cell number and higher metabolic activity than planktonic cells or free cells when exposed to lignocellulosic hydrolysate containing toxic inhibitors. However, there has not yet been a systematic study on the tolerance level of Z. mobilis biofilm compared to planktonic cells against model toxic inhibitors derived from lignocellulosic material. We took the first insight into the concentration of toxic compound (formic acid, acetic acid, furfural, and 5‐HMF) required to reduce the metabolic activity of Z. mobilis biofilm and planktonic cells by 25% (IC25), 50% (IC50), 75% (IC75), and 100% (IC100). Z. mobilis strains ZM4 and TISTR 551 biofilm were two‐ to three fold more resistant to model toxic inhibitors than planktonic cells. Synergetic effects were found in the presence of formic acid, acetic acid, furfural, and 5‐HMF. The IC25 of Z. mobilis ZM4 biofilm and TISTR 551 biofilm were 57 mm formic acid, 155 mm acetic acid, 37.5 mm furfural and 6.4 mm 5‐HMF, and 225 mm formic acid, 291 mm acetic acid, 51 mm furfural and 41 mm 5‐HMF, respectively. There was no significant difference found between proteomic analysis of the stress response to toxic inhibitors of Z. mobilis biofilm and planktonic cells on ZM4. However, TISTR 551 biofilms exhibited two proteins (molecular chaperone DnaK and 50S ribosomal protein L2) that were up‐regulated in the presence of toxic inhibitors. TISTR 551 planktonic cells possessed two types of protein in the group of 30S ribosomal proteins and motility proteins that were up‐regulated.
Development of an open experimentation tool based on JavaScript for the control of a four‐tank plant
Authors: Perez‐Castro Agustin , Sanchez‐Moreno Jose , Castilla Maria del Mar 
Published: September 2017

AbstractAt present, one of the main problems which can be found within chemical engineering education is the availability of real industrial plants able to provide an experimentation framework. The importance of this kind of plants lies in allowing students to apply the learned theoretical concepts to solve real problems. In this paper, a remote tool for educational purposes is presented. More specifically, the implementation of a four‐tank plant, its internal control design and the implementation of an EasyJava tool for executing JavaScript code in both simulation and real experimental tests have been widely described. As a result, a tool that allows to perform experimental tests over the plant in both real and simulation modes has been obtained. In this tool, the limits of use are imposed by the plant and not by the own tool.
Anger parameters in parolees undergoing psychoeducation: Temporal stability, social desirability bias, and comparison with non‐offenders
Authors: Fernandez Ephrem , Kiageri Vasiliki , Guharajan Deepan , Day Andrew 
Published: September 2017

AbstractBackgroundAnger is commonly measured as if it were a single, simple construct. This may be particularly unhelpful if the main purpose of a measure is to determine change and responsiveness to interventions.AimsOur primary aim was to assess five anger parameters in parolees – frequency, duration, intensity, latency, and threshold – and to test for effects of psychoeducation and social desirability bias on parolees' scores. Average anger scores for the offender sample were compared with those in a non‐offender sample.MethodsThe offender sample was drawn from male parolees in San Antonio. Age‐matched volunteers recruited at public libraries were engaged for baseline comparisons. The Anger Parameters Scale and the Marlow–Crowne Scale were used to assess anger and social desirability, respectively. Parole officers delivered a psychoeducation course to parolees over 12 weeks, and anger and social desirability measures were taken before and afterwards.ResultsAt baseline, parolees were angry more often, stayed angry longer, and reached higher levels of anger than the non‐offenders, confirming their eligibility for the programme. Mean anger scores were not significantly different after psychoeducation than before it. Parolees' reported anger was significantly and negatively correlated with social desirability scores.ConclusionsOnly three of the five anger parameters were prominent among these offenders: frequency, duration, and intensity of their outbursts. Psychoeducation did not produce improvement, possibly because it was instructional rather than therapeutic, but also because group means may mask useful individual differences. Concurrent assessment of social desirability is likely to assist in interpretation of anger measures. Copyright © 2017 John Wiley & Sons, Ltd.
Heparin or bivalirudin for non‐primary PCI: Beware of neat and simple answers…
Authors: Deliargyris Efthymios N. , Kimmelstiel Carey 
Published: September 2017

Key Points

The debate regarding the choice of heparin or bivalirudin as the preferred anticoagulant in PCI is still ongoing
Nonrandomized registry data are severely limited for comparative analyses and should therefore always be interpreted with caution
Clinicians should resist simplistic data interpretations or populist cries relating to cost, but rather focus on valid benefit:risk analyses for their clinical decision making
Role of Acid in Tailoring Prussian Blue as Cathode for High‐Performance Sodium‐Ion Battery
Authors: Liu Yang , Wei Gangya , Ma Mengyue , Qiao Yun 
Published: September 2017

AbstractPrussian blue (PB) with concave centers is synthesized successfully through a hydrothermal method with the assistance of acid. In this study, the role of the acid is investigated systematically by adjusting the reaction temperature and time, using different kinds and amounts of acid, and changing the amount of PVP surfactant added. It is found that the acid can not only trigger the chemical reaction to form cubic PB, but also act as an etching reagent to tailor the morphology. The as‐obtained cubic PB with concave centers demonstrates a superior cycle stability and rate performance, which can achieve a capacity of 107 mA h g−1 at 0.2 A g−1. The corresponding capacity retention is 74 % after 500 cycles relative to the second cycle. Even at a current density of 5 A g−1, the specific capacity remains at 82 mA h g−1. Furthermore, the full cell, using PB as the cathode and hard carbon as the anode, exhibits a high capacity of 70 mA h g−1 at 0.1 A g−1, and can power an LED light successfully. This work provides new insights into the role of acid in tailoring the morphology of PB, and opens a new avenue toward the design of unique structures to improve sodium storage.
Selective Stabilization of the Spin States of a Magnetically Anisotropic Dysprosium Ion Induced by Photo‐Excitation of the Associated Cyclic π‐Conjugated System
Authors: Fukuda Takamitsu , Ozawa Hideaki , Sakaguchi Yutaro , Kizaki Kazuro , Kobayashi Toshiya , Fuyuhiro Akira , Ishikawa Naoto 
Published: September 2017

AbstractThe presence of a new electronic interaction, which couples a 4 f‐electronic system with a total angular momentum J and a photoexcited cyclic π‐conjugated system with an orbital angular momentum L, in the bis(phthalocyaninato)dysprosium single‐molecule magnet ([DyPc2]−) is reported. Two π–π* excited states in the visible spectral region of the [DyPc2]− complex, which are denoted here as QL and QH, showed significantly different temperature and field dependences of the magnetic circular dichroism (MCD) A‐term intensity. This phenomenon not only indicates the presence of a “J–L” interaction, but also that the interaction generates two different preferred orientations of the J–L pair, either parallel (for the QH band) or antiparallel (for the QL band), depending on the excitation energy. We have constructed a theoretical model that reproduces the temperature and field dependences, and quantitatively evaluated the J–L interaction.
Perfluoroalkyltricyanoborate and Perfluoroalkylcyanofluoroborate Anions: Building Blocks for Low‐Viscosity Ionic Liquids
Authors: Landmann Johannes , Sprenger Jan A. P. , Hennig Philipp T. , Bertermann Rüdiger , Grüne Matthias , Würthner Frank , Ignat'ev Nikolai V. , Finze Maik 
Published: September 2017

AbstractThe potassium perfluoroalkyltricyanoborates K[CnF2 n+1B(CN)3] [n=1 (1 d), 2 (2 d)] and the potassium mono(perfluoroalkyl)cyanofluoroborates K[CnF2 n+1BF(CN)2] [n=1 (1 c), 2 (2 c)] and [CnF2 n+1BF2(CN)]− [n=1 (1 b), 2 (2 b), 3 (3 b), 4 (4 b)] are accessible with perfect selectivities on multi‐gram scales starting from K[CnF2 n+1BF3] and Me3SiCN. The K+ salts are starting materials for the preparation of salts with organic cations, for example, [EMIm]+ (EMIm=1‐ethyl‐3‐methylimidazolium). These [EMIm]+ salts are hydrophobic room‐temperature ionic liquids (RTILs) that are thermally, chemically and electrochemically very robust, offering electrochemical windows up to 5.8 V. The RTILs described herein, exhibit very low viscosities with a minimum of 14.0 mPa s at 20 °C for [EMIm]1 c, low melting points down to −57 °C for [EMIm]2 b and extraordinary high conductivities up to 17.6 mS cm−1 at 20 °C for [EMIm]1 c. The combination of these properties makes these ILs promising materials for electrochemical devices as exemplified by the application of selected RTILs as component of electrolytes in dye‐sensitised solar cells (DSSCs, Grätzel cells). The efficiency of the DSSCs was found to increase with a decreasing viscosity of the neat ionic liquid. In addition to the spectroscopic characterisation, single crystals of the potassium salts of the anions 1 b–d, 2 d, 3 b and 4 c as well as of [nBu4N]2 c have been studied by X‐ray diffraction.