bluuebunny/crossref_metadata_2025_split huggingface dataset:
TO DETERMINE THE FREQUENCY OF ALDEHYDE DEHYDROGENASE TYPE 2 (ALDH2) DEFICIENCY IN APLASTIC ANAEMIA: A SINGLE CENTER EXPERIENCE FROM PAKISTAN
Authors: Shamim Noor , Mehreen Ali Khan  , Raheel Iftikhar  , Zaineb Akram  , Hina Jamshaid  , Jahanzeb Rehman  , Qamar un Nisa Chaudhry  , Tariq Ghafoor  
Published: October 2024

Background: Aplastic anaemia is a rare bone marrow failure syndrome and is defined by pancytopenia associated with a hypo-cellular bone marrow with no increase in reticulin and in the absence of any abnormal infiltrate. The objective of the study was to determine the frequency of Aldehyde Dehydrogenase type 2 (ALDH2) deficiency in patients with Aplastic Anaemia and investigate its correlation with patient and disease characteristics. It was a descriptive cross-sectional study conducted at Armed Forces Bone Marrow Transplant Centre Rawalpindi from 01-08-2022-01-02-2023, over a period of 6 months. Methods: A total of 56 patients who were diagnosed with aplastic anaemia during this period, fulfilling inclusion criteria were enrolled. Patients were genotyped as GG (homozygous) and GA (heterozygous). GG had normal ALDH2, while GA were patients with ALDH2 deficiency. Data was collected on the patient's demographics, type and severity of anaemia, type of hematopoietic stem cell transplant (HSCT) and frequency of ALDH2 deficiency. Results were analyzed for ALDH2 deficiency and its correlation with patient and disease characteristics was investigated. Results: A total of 56 patients were included in the study. The median age of the patients was 28 years (20-39). According to the type of aplastic anaemia, 2 (3.6%) had Fanconi anaemia and 54 (96.4%) had acquired aplastic anaemia. In our study, 18 (32.1%) patients had undergone HSCT while the remaining 38 (67.9%) could not undergo HSCT. The frequency of the presence of ALDH2 deficiency was 2 (3.6%). There was no statistically significant correlation between the frequency of ALDH2 deficiency with variables like gender, age distribution, type of aplastic anaemia, the severity of aplastic anaemia and hematopoietic stem cell transplant. Conclusion: We concluded from our study the frequency of ALDH2 was rare in patients with aplastic anaemia. There was no statistically significant co-relation between the frequency of ALDH2 deficiency with variables like gender, age distribution, type of aplastic anaemia, the severity of aplastic anaemia and hematopoietic stem cell transplant.
RESIDUAL LEVEL OF DELTAMETHRIN INDUCED GASTRITIS AND PREVENTIVE ROLE OF CURCUMIN ON STOMACH MUCOSA
Authors: Amna Halima  , Wajid Akbar  , Haider Ali  , Muhammad Junaid  , Imtiaz Humaira , Sumaira Javed  
Published: October 2024

Background Benefits of Curcumin for health have been explained by different experimental models and clinical trials. It is a very potent antioxidant. Curcumin was found to play a preventive and curative role in both acute and chronic gastritis. Deltamethrin is a useful pesticide when applied with caution to crops. However, it also has noxious effects on gastric mucosa once ingested with sprayed crops. Its maximum permissible limit, MRL (Maximum Residual Level) as pesticide food residues is 5mg/kg body weight as defined by WHO. However, there is still a potential to cause harm at these levels and may be a serious potential health hazard. The present study aimed to: (a) determine the prevalence and severity of gastritis induced by deltamethrin when administered at MRL doses and (b) To observe the preventive effect on gastric mucosa against the action of Deltamethrin present as a residual pesticide in different vegetables and fruits. Methods In this two-phase subacute toxicity study of seven weeks, forty Sprague Dawley rats were divided into eight subgroups. Control groups were kept on a normal diet and sesame oil. Out of the two treatment groups, one group was given deltamethrin (5mg/kg body weight) orally along with curcumin 100mg/kg body weight. The second group was first given deltamethrin (5mg/kg body weight) and curcumin (200mg/kg). All were culled at its end. The stomach samples were collected and processed to obtain histology slides for analysis via microscopy and micrometry. Grading was done to look for changes according to the Visual Analogue Scale and Operative Link on Gastritis Assessment (OLGA). Results The experimental deltamethrin group when compared to control groups, revealed mild changes in stomach histomorphology while curcumin-treated both groups; Group D (100mg/kg) and Group E (200mg/kg) showed no changes. Conclusion Administration of Deltamethrin even in maximum residual dose (permissible) is proven to be toxic. Curcumin is hence proved to protect the gastric mucosa against the toxic effects of deltamethrin ingested in residual form.
PREDICTIVE POTENTIAL OF IL28B GENE IN HCV PATIENTS, RESISTANT TO DACLATASVIR AND SOFOSBUVIR IN KPK POPULATION
Authors: Sardar Sunya , Sardar Muhammad  , Mohsina Haq  , Najib ul Haq  , Khan Arbab Muhammad Kashif 
Published: October 2024

Background: Recently various combinations of direct acting antivirals (DAAs) have been tried successfully. Sofosbuvir + Daclatasvir combination has been used with promising results. Recently, resistance has been noticed against DAAs. Therefore, polymorphism at particular sites in the interleukin 28B gene are under study to find possible association with resistance. This study was aimed at finding out any association of SNPs rs8099917 and rs12979860 (IL28B gene) with response and resistance to treatment in HCV genotype 3 patients in Khyber Pakhtunkhwa. Methods: This cross sectional, Analytical study was conducted at Gastroenterology/hepatology OPD of Prime Teaching Hospital, Peshawar Medical College. Collected Samples were stored at -20o C in PCR Lab of the College. DNA extraction and genotyping was carried out at BJ Molecular Biology Lab in Rawalpindi. Data was analyzed by using SPSS version 21. Chi-Square Test was used to see the statistically significant differences between rs8099917 T/G and rs12979860 T/C model. Results: In the IL28-B gene, single nucleotide polymorphism at rs12979860 T/C model, we observed that there are 37.5% CC homozygous, 12.5% TT homozygous and 50% CT heterozygous genotypes in resistant patients and 42.85% CC homozygous, 28.57% TT and 28.57% CT genotype in responder group. In rs12979860 T/C model, genotype of IL28-B in the responder and resistant group significantly varies at p-value =0.00572. Conclusion: We conclude that in SNP at rs12979860, CC genotype is associated with clearance of HCV, while CT genotype was more prevalent in the resistant group and associated with chronicity.
METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS AND ITS ANTIBIOTIC SENSITIVITY PATTERN IN PATIENTS WITH VESICULOBULLOUS DISORDERS
Authors: Hamid Ur Raziq  , Ullah Ghafoor , Ali Farhad , Ziaulhaq Muhammad , Ali Rahmat 
Published: October 2024

Background: Vesiculobullous disorders are among the leading causes of admission to dermatology. These are characterized by distinct mucocutaneous involvement and by the development of vesicles and bullae (i.e. blisters). Methicillin-resistant Staphylococcus aureus (MRSA) is a group of gram-positive bacteria distinct from other strains of Staph aureus. As the susceptibility of bacteria to antibiotics varies from region to region and from time to time, this study will determine the pattern of antimicrobial susceptibility of MRSA isolates to the commonly prescribed antibiotics in our population. The objective is to determine the frequency of methicillin-resistant Staphylococcus aureus and its antibiotic sensitivity pattern in patients with vesiculobullous disorders admitted to the Dermatology unit of Lady Reading Hospital (LRH), Peshawar. It was Cross-sectional and carried out in study Department of Dermatology, Lady Reading Hospital, Peshawar from Oct 23, 2020, to Apr 22, 2021. Methods: This study was carried out over 132 patients. After consent, Swabs of pus from the Vesiculobullous disorders were taken from all the patients and sent to a laboratory for culture. Staphylococcus aureus (MRSA) was labelled as Staphylococcus aureus bacteria by Kirby-Bauer disc diffusion method using oxacillin (1 Î¼ gm.) disc on Mueller-Hinton agar (HiMedia Labs, Mumbai) with 24 hours incubation at 35°C. Results: In this study, 132 patients were observed. The average age was 44.44 years ±13.74 SD. Male to female ratio was 1.30:1. There were 44(33.33%) patients who showed Methicillin Resistant Staphylococcus aureus (MRSA) in vesiculobullous disorders patients. Conclusion: In our population, the frequency of staphylococcus aureus bacteria in vesiculobullous disorders is high so it will be considered while treating such patients.
EVALUATION AND MEASURE OF ACCURACY OF ICT, CLIA AND NAT FOR THE DETECTION OF HEPATITIS B, C AND HIV IN THE BLOOD DONORS ABSTRACT
Authors: Irshad Romana , Umer Farooq  , Ihsan Ullah  , Abeera Farooq  , Tahir Shah  , Adeel Gul  
Published: October 2024

Background: A sensitive and specific donor screening strategy is essential for the prevention of transfusion-transmitted infections (TTI). The study was conducted to ascertain the comparative efficacy of ICT, CLIA and NAT methods. Methods: This cross-sectional analytical study was conducted in Regional Blood Center Abbottabad, Pakistan from 1st April to 25 August 2022. 6233 donors were screened for Hep B, C, and HIV by testing simultaneously with ICT, CLIA and NAT. Results: Active Hep B, C and HIV Infection was present in 0.51%, 0.28% and 0.00048% donors respectively. The sensitivity was found to be higher for HBV and HIV with CLIA as compared to ICT but was equal for HCV with both. whereas specificity was the same with both CLIA and ICT for all three viruses. PPV was higher with ICT for HBV and HCV, but for HIV it was found higher by CLIA. NPV was higher for all three viruses by CLIA as compared to ICT. Conclusion: In case rapid testing devices are used for the initial screening of blood in countries with limited resources, positive cases must be confirmed by CLIA and if possible, then by NAT because of missing cases in the window period and false positive cases.
EFEKTIVITAS APLIKASIBEBEJA MENUJU DIGITALISASI PEMERINTAHAN KABUPATEN PANDEGLANG
Authors: Muhammad Taufik Harsana  
Published: October 2024

Setelah disahkannya Perpres No 76 tahun 2013 tentang pengelolaan pengaduan pelayanan publik. Sejak 17 agustus 2017 pemerintah Kabupaten Pandeglang membuka pelayanan pengaduan masyarakat berupa pengaduan melalui aplikasi yang bernama Bebeja.Pelayanan dalam bentuk elektronik sangat diharapkan oleh masyarakat, karena dirasakan efektif, khususnya dalam hal pengaduan. Oleh karena itu penulis merasa perlu untukmengetahui efektivitas pelayanan tersebut.Efektivitas Pelayanan pengaduan masyarakat melalui aplikasi Bebeja ini dapat diketahuidengan menggunakan teori Efektivitas menurut Siagian (2013:20-21) dengan dimensi : (1)Sumber daya, dana, sarana dan prasarana (2) Jumlah dan mutu barang (3) Batas waktu. (4)Tata cara yang harus ditempuh dalam menyelesaikan tugas. Penelitian ini menggunakantipe penelitian deskriptif dengan pendekatan kualitatif.Hasil penelitian ini menunjukan bahwa Hasil penelitian yangdiperoleh yaitu : 1) Sumber daya, dana, sarana dan prasarana, sudah sesuai dengan ketentuan yang berlaku dan mampu mendukung kelancaran kegiatan pelayanan 2) Jumlah dan mutu pelayanan yangdihasilkan, banyaknya masyarakat yang berpartisipasi dalam pelayanan ini dan mutu pelayanan yang dapat tercermin dari keakuratan laporan dan kemudahan dalam pelayanan 3) Batas waktu, proses pelayanan pengaduan ini sudah sesuai 4) Tata cara pelayanan yang harus ditempuh sudah sesuai dengan KEMENPAN Nomor 63 tahun 2003 dimana penyelenggara pelayanan publik harus memenuhi beberapa prinsip salah satunya yaitu kesederhanaan.
PERLINDUNGAN HUKUM TERUMBU KARANG DI TAMAN NASIONAL TAKABONERATE YANG MENGALAMI KERUSAKAN AKIBAT PENAMBANGAN KARANG
Authors: Bangsawan Andi Rijal , Hasan Yulia A. , Rusli Muhammad 
Published: October 2024

Penelitian ini bertujuan untuk mengetahui lebih dalam upaya perlindungan hukum terhadap terumbu karang yang mengalami kerusakan akibat penambangan karang di Taman Nasional Takabonerate kendala dan solusi yang diberikan. Tipe penelitian normatif-empiris. Jenis data yang digunakan yaitu data primer dan data sekunder, data primer diperoleh langsung melalui informasi menggunakan teknik wawancara oleh Dinas Lingkungan Hidup Kab. Kepulauan Selayar, Kepala Balai Taman Nasional Takabonerate/Staf yang menangani langsung objek penelitian penulis. Sedangkan data sekunder diperoleh dari penelitian kepustakaan dengan mempelajari buku-buku, Perundang-undangan dan jurnal yang berhubungan dengan muatan penulis skripsi ini. Hasil penelitian Upaya perlindungan hukum terhadap kerusakan terumbu karang akibat penambangan karang sebagai bahan bangunan rumah sudah sesuai dengan aturan yang ada dan sudah dijalankan oleh Balai Taman Nasional Takabonerate yang dilakukan pertama kali ialah mendatangi dan melakukan mediasi mencari jalan keluar dan mendapatkan kesepakatan untuk dibongkar dan dikembalikan ke tempat yang semula. Adapun SDM aparatur Taman Nasional Takabonerate terhadap kendala yang dihadapi sangat minim dikarenakan mereka melakukan koordinasi oleh pemerintah daerah terkait, kecamatan dan desa yang berkaitan langsung kasus tersebut, seperti Sat Polair Polres Kab. Kepulauan Selayar. Serta solusi yang diberikan melakukan sosialisasi, tindakan preventif, pendekatan kepada masyarakat, dengan melibatkan tokoh agama, tokoh pendidik, tokoh pemuda.
This study aims to find out more about legal protection efforts for coral reefs that have been damaged by coral mining in Takabonerate National Park, the constraints and solutions provided. Type of normative-empirical research. The types of data used are primary data and secondary data. Primary data is obtained directly through information using interview techniques by the District Environmental Office. Selayar Archipelago, Head of the Takabonerate National Park Agency/Staff who directly handles the author's research object. Meanwhile, secondary data was obtained from library research by studying books, laws and journals related to the content of this thesis writer. The results of the research Efforts to protect the law against damage to coral reefs due to coral mining as a building material for houses are in accordance with existing regulations and have been carried out by the Takabonerate National Park Office. original place. The human resources of the Takabonerate National Park apparatus for the obstacles they face are very minimal because they coordinate with the relevant local governments, sub-districts and villages that are directly related to the case, such as Sat Polair Polres Kab. Selayar Islands. As well as the solutions given are socialization, preventive measures, approaches to the community, involving religious leaders, educators, youth leaders.
PERLINDUNGAN HUKUM TERHADAP SAKSI PELAPOR DALAM TINDAK PIDANA KEKERASAN SEKSUAL DI PANGKAJENE DAN KEPULAUAN
Authors: Hasdi Cipta Anugrah , Renggong Ruslan , Madiong Baso 
Published: October 2024

Penelitian ini bertujuan untuk menganalisis efektifitas perlindungan hukum terhadap saksi pelapor dalam tindak pidana kekerasan seksual di Kabupaten Pangkajene dan Kepulauan dan menganalisis faktor yang mempengaruhi terjadinya tindak pidana kekerasan seksual di Kabupaten Pangkajene dan Kepulauan. Penelitian ini merupakan penelitian normatif-empiris dengan pendekatan kualitatif yang dilakukan di Kantor Kepolisan Resort Pangkajene dan Kepulauan. Metode yang gunakan adalah wawancara, dan studi kepustakaan. Hasil penelitian menunjukkan bahwa: 1) efektifitas perlindungan hukum terhadap saksi pelapor dalam tindak pidana kekerasan seksual di Kabupaten Pangkajene dan Kepulauan dilakukan dengan memberikan perlindungan berupa: (a) perlindungan identitas, (b) perlindungan fisik, meski demikian perlindungan belum berjalan dengan efektif; 2) faktor yang mempengaruhi perlindungan hukum terhadap saksi pelapor dalam tindak pidana kekerasan seksual di Kabupaten Pangkajene dan Kep yaitu: (a) faktor internal yang terdiri dari (1) pelaku dan (2) korban, (b) faktor eksternal yang terdiri dari: (1) keluarga, (2) lingkungan, (3) hukuman, (4) Kebudayaan
This study aims to: 1) identify and analyze the effectiveness of legal protection for reporting witnesses in crimes of sexual violence in Pangkajene and Islands districts; 2) to find out and analyze the factors that influence the occurrence of crimes of sexual violence in Pangkajene and Islands districts. This research is a normative-empirical research with a qualitative approach conducted at the Pangkajene and Islands Resort Police Office. The methods used are interviews and literature studies. The results of the study show that: 1) the effectiveness of legal protection for reporting witnesses in the crime of sexual violence in Pangkajene and Islands districts is carried out by providing protection in the form of: (a) identity protection, (b) physical protection, although this protection has not been effective; 2) factors that influence legal protection for reporting witnesses in the crime of sexual violence in Pangkajene and Kep Regencies, namely: (a) internal factors consisting of (1) perpetrators and (2) victims, (b) external factors consisting of: ( 1) family, (2) environment, (3) punishment, (4) culture
ANALISIS HUKUM TINDAK PIDANA PENCEMARAN NAMA BAIK MENURUT HUKUM ADAT INDONA SESENAPADANG
Authors: Ferdynando Ferdynando , Renggong Ruslan , Makkawaru Zulkifli 
Published: October 2024

Penelitian ini bertujuan untuk mengetahui : penyelesaian tindak pidana pencemaran nama baik menurut hukum adat di wilayah Adat Indona Sesenapadang Kabupaten Mamasa dan penyelesaian tindak pidana menurut hukum adat telah memenuhi rasa keadilan masyarakat di wilayah Indona Sesenapadang. Penelitian ini dilakukan di Kabupaten Mamasa Kecamataan Sesenapadang. Tipe penelitian ini adalah penelitian kualitatif dengan metode pendekatan normatif dan empiris yang dilakukan dengan menelaah hukum dalam kenyataan. Sumber data yang digunakan di dalam penelitian ini diambil dari data primer dan data sekunder. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu Penelitian Pustaka dengan dengan membaca referensi hukum, perundang-undangan, serta dokumen-dokumen, dan penelitian lapangan dengan melakukan wawancara secara langsung. Berdasarkan hasil penelitian dapat disimpulkan bahwa ; 1) penyelesaian tindak pidana pencemaran nama baik menurut hukum adat di wilayah Adat Indona Sesenapadang Kabupaten Mamasa, yaitu didasarkan pada sistem Ada’ Tuo Tang Mate, Mapia Tang Kadake artinya bahwa penyelesain tindak pidana mengedepankan rasa kemanusiaan dimana setiap penyelesaian tindak pidana tidak mengedepankan ego dalam diri seseorang tetapi lebih kepada persetujuan yang akan merujuk kepada hal-hal baik dan akan dijadikan sebagai suatu kesimpulan; 2) penyelesaian tindak pidana menurut hukum adat telah memenuhi rasa keadilan masyarakat di wilayah Indona Sesenapadang, bahwa penerapan sanksi di wilayah Adat Indona Sesenapadang sudah berlaku adil pada masyarakat yang tinggal dalam wilayah tersebut, dibuktikan dengan tidak adanya masyarakat yang merasa dirugikan, hal ini didasarkan pada keadaan ekonomi masyarakat atau strata sosial dimana masyarakat yang melakukan tindak pidana akan dijatuhi saksi sesuai dengan kemampuan pelaku (umpotakin takinna).
Pendampingan Anak Tuna Netra SLB-A Yapti Kota Makassar
Authors: Yana Sa Hilda , Asmirah Asmirah , Burchanuddin Andi 
Published: October 2024

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan tentang proses, pendampingan, dan evaluasi pembelajaran orientasi dan mobilitas bagi anak tunanetra di SBL-A YAPTI Kota Makassar. Penelitian ini menggunakan metode penelitian deskriptif kualitatif yang dilakukan di SLB-A YAPTI KotaMakassar. Subjek penelitia yaitu guru kelas siswa tunantera. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Keabsahan data diuji menggunakan triangulasi teknik. Proses pelaksanaan pembelajaran dilaksanakan lima jam pelajaran dalam lima hari yang dilakukan sendiri oleh guru kelas, yang terdiri dari tiga tahap yaitu kegiatan pendahuluan, kegiatan inti dan kegiatan penutup. Evaluasi dari rancangan dan proses pelaksanaan pembelajaran dilakukan setelah pembelajaran orientasi dan mobilitas selesai..
This research aimed to knew and described the design, occompaniment, and evaluation of learning orientation and mobility for child Blind in SLB-A Yapti Makassar City. This research used a descriptive qualitative research method that was done in SLB-A Yapti Makassar City. The research subject was a class of visually impaired student teacher. Data collection techniques used observation, interviews and documentation. Validity of data was tested using the triangulation technique. The process of learning is carried five hours of lessons in a five days conducted alone by the class teacher, consisting of three stages, namely preliminary activities, core activities and closing activities. Evaluation of the design and process of learning implementation is carried out after orientation and mobility learning is completed.
Strategi Pengembangan Pengusaha Kopra Di Kecamatan Tomoni Timur
Authors: Suardana Wayan , Azuz Faidah , Salam Suryawati 
Published: October 2024

Coconut is a copra-producing plant that can be developed to offset palm cooking oil. This study aims to 1) determine the copra development strategy, 2) analyze the condition of the strengths and weaknesses factors as well as the conditions of the opportunities and threats factors in copra business development. The method used in this research is qualitative. 6 main informants (people) who are copra entrepreneurs in Tomoni Timur District. Data obtained through in-depth interviews. This study resulted in 1). The most appropriate strategy to apply is good copra quality and prospective long-term potential. 2), IFAS internal strategy in the form of strengths and weaknesses obtained a value of 2.61, which consists of 1.96 strengths (Strenghts) and 0.65 weaknesses (Weaknes). This condition shows that internally the development of the copra business is still very good to be developed. The EFAS External Strategy in the form of opportunities and threats obtained a total score of 2.25 consisting of 1.59 scores for Opportunities and 0.66 scores for Threats. This condition illustrates that externally, development in the copra business includes business good to develop.
Kelapa merupakan tanaman penghasil kopra yang dapat dikembangan untuk mengimbangi minyak goring kelapa sawit. Penelitian ini bertujuan untuk 1) mengetahui strategi pengembangan kopra, 2) menganalisis kondisi faktor kekuatan dan kelemahan serta kondisi faktor peluang dan ancaman dalam pengembangan usaha kopra. Metode yang digunakan dalam penelitian ini yaitu kualitatif. Informan utama 6 (orang) yang merupakan pengusaha kopra yang ada di Kecamatan Tomoni_Timur. Data diperoleh melalui wawancara mendalam. Kajian ini menghasilkan 1). Strategi yang paling tepat diterapkan yaitu kualitas kopra yang baik dan potensi jangka panjang masih prospektif. 2), Strategi internal IFAS berupa kekuatan dan kelemahan diperoleh nilai sebesar 2,61, yang terdiri dari 1,96 kekuatan (Strenghts) dan 0,65 kelemahan (Weaknes). Kondisi ini menunjukan bahwa secara internal pengembangan pada usaha kopra masih sangat baik untuk dikembangkan. Strategi Eksternal EFAS berupa peluang dan ancaman total skor yang diperoleh sebesar 2,25 yang terdiri dari 1,59 skor peluang (Opportunities) dan, 0,66 skor untuk ancaman (Threats) kondisi ini menggambarkan bahwa secara eksternal, pengembangan pada usaha kopra termasuk usaha yang baik untuk dikembangkan.