bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal assessment of health-related quality of life in Japanese patients with advanced urothelial carcinoma receiving immune check point inhibitors
Authors: Miyake Makito , Nishimura Nobutaka , Oda Yuki , Miyamoto Tatsuki , Iida Kota , Tomizawa Mitsuru , Shimizu Takuto , Owari Takuya , Ohnishi Kenta , Hori Shunta , Morizawa Yosuke , Gotoh Daisuke , Nakai Yasushi , Torimoto Kazumasa , Fujii Tomomi , Tanaka Nobumichi , Fujimoto Kiyohide 
Published: October 2024

AbstractReal-world data on health-related quality of life (HRQoL) in advanced urothelial carcinoma (aUC) receiving immune checkpoint inhibitors (ICIs) are limited. This study included 42 patients with aUC who received second-line or later pembrolizumab (n = 19), maintenance avelumab followed by first-line chemotherapy (n = 13), or adjuvant nivolumab after radical surgery (n = 10). Time-course changes in the domains and scales related to HRQoL were evaluated using the EORTC QLQ-C30, FACT-G, and SF-8 questionnaires during ICI therapy. Anchor-based approaches for minimally important differences were determined as ‘improved’, ‘stable’, and ‘deteriorated’. We found significant improvements after the start of pembrolizumab treatment on many scales. Almost none of the scales changed significantly in the avelumab and nivolumab groups. Approximately 80% of the pembrolizumab group had deteriorated social/family well-being in FACT-G. Approximately 60% of the patients in the avelumab group had deteriorated general health and vitality in SF-8. In the nivolumab group, none of the scales deteriorated in > 50% of the patients. Deterioration of physical function in the SF-8 was associated with occurrence of treatment-related adverse events ≥ grade 2 during ICI therapy (P = 0.013). Our findings demonstrated that majority of patients with aUC who received ICI therapy had a stable HRQoL, which was consistent with evidence from clinical trials.
Pharmacokinetic and pharmacodynamic evaluation of various vasopressin doses and routes of administration in a neonatal piglet model
Authors: Ramsie Marwa , Cheung Po-Yin , O’Reilly Megan , Lee Tze-Fun , Schmölzer Georg M. 
Published: October 2024

AbstractEpinephrine is the only recommended vasopressor during neonatal cardiopulmonary resuscitation. However, there are concerns about the potential adverse effects of epinephrine, which might hamper efficacy during cardiopulmonary resuscitation. An alternative might be vasopressin, which has a preferable adverse effect profile, however, its optimal dose and route of administration is unknown. We aimed to compare the pharmacodynamics and pharmacokinetics of various vasopressin doses administered via intravenous (IV), intraosseous (IO), endotracheal (ETT), and intranasal (IN) routes in healthy neonatal piglets. Forty-four post-transitional piglets (1–3 days of age) were anesthetized, intubated via a tracheostomy, and randomized to receive vasopressin via intravenous (control), IO, ETT, or IN route. Heart rate (HR), arterial blood pressure, carotid blood flow, and cardiac function (e.g., stroke volume, ejection fraction) were continuously recorded throughout the experiment. Blood was collected prior to drug administration and throughout the observation period for pharmacodynamics and pharmacokinetic analysis. Significant changes in hemodynamic parameters were observed following IO administration of vasopressin while pharmacokinetic parameters were not different between IV and IO vasopressin. Administration of vasopressin via ETT or IN did not change hemodynamic parameters and had significantly lower maximum plasma concentrations and systemic absorption compared to piglets administered IV vasopressin (p < 0.05). The IV and IO routes appear the most effective for vasopressin administration in neonatal piglets, while the ETT and IN routes appear unsuitable for vasopressin administration.
The discovery of a fossil whitefly from Lower Lusatia (Germany) presents a challenge to current ideas about Baltic amber
Authors: Drohojowska Jowita , Zmarzły Marzena , Szwedo Jacek 
Published: October 2024

AbstractThe whiteflies (Hemiptera: Aleyrodidae) are small sternorrhynchan insects, which have the potential to cause significant economic damage to agricultural crops. There is a paucity of knowledge regarding the diversity, disparity, and evolutionary history of these insects, with classification based on the immatures, called puparia. The fossil record of whiteflies is sparse and incomplete, with the majority of fossils representing imaginal forms preserved as inclusions in fossilized resins. In this study, we present the first inclusion in succinite associated with the layers of Lower/Middle Miocene 2nd Lusatian Lignite Seam of Wanninchen in Brandenburg, Germany. The objective of the present study is to elaborate this fossil, and as a consequence, a new fossil genus and species, Pudrica christianottoi gen. et sp. nov., is described. This fossil is a representative of the subfamily Aleyrodinae, and it is the third fossil genus of this whitefly subfamily to be described. The discovery of the fossil inclusion in the succinite from the lignite deposits of Lower Lusatia challenges the current understanding of the character and conditions of formation and deposition of central and east European Paleogene fossil resins. Succinite is a fossil resin that occurs in the Eocene deposits of the Gulf of Gdańsk, belonging to the Prussian Formation, containing a glauconite-rich horizon known as the ‘Blue Earth’. Similarly, glauconite-rich deposits are present in the Lublin area of Poland, where they are associated with the occurrence of succinite. Additionally, succinite has been found in deposits in the Rovno-Zhitomir area of Ukraine, which are alluvial deposits containing glauconite and lignite layers. Succinite was also identified in Eocene strata of Spitsbergen and in Axel Heiberg Island in the Canadian Arctic. Succinite has also been discovered in early Miocene deposits in Bitterfeld, Germany, where it occurs alongside lignite deposits (the deposit actually encompasses different fossil resins, so potentially originating from different source plants). Furthermore, it has been identified in younger (Pleistocene) deposits across Europe. The autochthonous (parautochthonous) character of the lignite deposits in Lower Lusatia raises questions regarding the time range of the succinite-producing gymnosperm trees and the autochthonous or allochthonous character of the lignite layers associated fossilized resins.
Preselection of potential target spaces based on partial information by the supplementary eye field
Authors: Yokoyama Osamu , Nishimura Yukio 
Published: October 2024

AbstractBefore selecting a saccadic target, we often acquire partial information about the location of the forthcoming target and preselect a region of visual space even before the target becomes visible. To determine whether the supplementary eye field (SEF) represents information signifying the potential target space, we examined neuronal activity in the SEF of monkeys performing a behavioral task designed to isolate the process of visuospatial preselection under uncertainty from the process of selecting a specified location. Our data showed that the activity of SEF neurons represented information about the potential target space instructed by symbolic cues. Increased activity of visuospatially selective SEF neurons encoded the potential target space, which could be a mechanism facilitating subsequent selection of an appropriate target. Furthermore, electrical stimulation of the SEF during the preselection period disrupted subsequent target selection. These results demonstrate that the SEF contributes to the preselection of potential target spaces based on partial information.
Super-resolved analysis of colocalization between replication and transcription along the cell cycle in a model of oncogene activation
Authors: Privitera Anna Provvidenza , Scalisi Silvia , Paternò Greta , Cerutti Elena , D’Amico Morgana , Pelicci Pier Giuseppe , Faretta Mario , Dellino Gaetano Ivan , Diaspro Alberto , Lanzanò Luca 
Published: October 2024

AbstractTo understand how oncogenes affect genome organization, it is essential to visualize fundamental processes such as DNA replication and transcription at high resolution in intact cells. At the same time, it is important to determine the progression of the cell along the cell cycle, as cell cycle regulation is crucial for the control of cell proliferation and oncogenesis. Here, we present a super-resolution imaging-based method to analyze single cell nuclei sorted according to specific phases of the cell cycle. The sorting is based on the evaluation of the number and the intensity of pixels in the replication foci image and the colocalization analysis is based on image cross-correlation spectroscopy (ICCS). We evaluate the colocalization between replication and transcription, at different cell cycle phases, in a model of PML-RARα oncogene activation. We find that colocalization between replication and transcription is higher in cells in early S phase compared to cells in middle and late S phase. When we turn on the PML-RARα oncogene, this colocalization pattern is preserved but we detect an increase of colocalization between replication and transcription in the early S phase which points to an effect of the PML-RARα oncogene on the coordination between replication and transcription.
Digital twin simulation modelling shows that mass testing and local lockdowns effectively controlled COVID-19 in Denmark
Authors: Græsbøll Kaare , Eriksen Rasmus Skytte , Kirkeby Carsten , Christiansen Lasse Engbo 
Published: October 2024

Abstract
Background
Following the COVID-19 pandemic, it is important to evaluate different mitigation strategies for future preparedness. Mass testing and local lockdowns were employed during the Alpha wave in Denmark, which led to ten times more tests than the typical European member state and incidence-based restrictions at the parish level. This study aims to quantify the effects of these interventions in terms of hospital admissions and societal freedom.

Methods
This study assesses the effectiveness of these strategies via counterfactual scenarios using a detailed, individual-based simulation model that replicates the entire Danish population. The model considers multiple factors, including evolving societal restrictions, vaccination roll-out, seasonal influences, and varying intensities of PCR and antigen testing across different age groups and degree of completed vaccination. It also integrates adaptive human behavior in response to changes in incidences at the municipality and parish levels.

Results
The simulations show, that without mass testing in Denmark, there would have been a 150% increase in hospital admissions, and additional local lockdowns equivalent to 21 days of strict national lockdown. Without the policy of local lockdowns, hospitalizations would have increased by 50%.

Conclusions
In conclusion, the combination of mass testing and local lockdowns likely prevented a large increase in hospitalizations while increasing overall societal freedom during the Alpha wave in Denmark. In future epidemics, mass testing and local lockdowns can likely prevent overwhelming healthcare systems in phases of high transmission and hospitalization risks.
Unlocking Insights: Exploring the Profiles of School-Based Telefacilitators
Authors: Douglass Hannah , Lowman Joneen , Mirakhur Zitsi 
Published: October 2024

Purpose:
School-based telefacilitators are critical yet underresearched members of telepractice programs. They are the face of the telepractice program and are often telepractice champions in their communities. However, we have little research explaining the typical profile of telefacilitators, making it more difficult to identify personnel characteristics that contribute to the implementation of sustainable telepractice programs. The purpose of this study was to describe the typical profile and preparation of school-based telefacilitators for physical, occupational, and speech therapy in the United States.

Method:
A cross-sectional survey gathered 21 telefacilitator responses about their primary job title, preparation, confidence, and basic demographics. Survey recruitment followed an adaptive sampling method with three phases: stratified random sampling, purposive sampling, and targeted convenience sampling. Results were analyzed using frequency counts and descriptive statistics where appropriate.

Results:
Most respondents held the primary job title of paraprofessional, but a diverse range of titles were reported, including superintendents and directors of special education. Half of the respondents received various methods of formal training for the role, whereas the other half were self-taught. Overall levels of confidence in job performance were high, yet self-taught telefacilitators felt that lack of training negatively impacted their performance. Most respondents had a bachelor's degree or higher.

Conclusions:
There is a high degree of variability in the profile and preparation of telefacilitators. Inconsistency in terminology and lack of agreed-upon job responsibilities are significant barriers to studying the role of telefacilitators and the ability to plan telepractice staffing needs adequately. Clinical implications and opportunities for future investigation are highlighted.

Supplemental Material:

https://doi.org/10.23641/asha.27115216
Recovery of coronal dimmings
Authors: Ronca G. M. , Chikunova G. , Dissauer K. , Podladchikova T. , Veronig A. M. 
Published: October 2024

Context. Coronal dimmings are regions of reduced emission in the lower corona observed in the wake of coronal mass ejections (CMEs), representing their footprints. Studying the lifetime evolution of coronal dimmings helps us to better understand the recovery and replenishment of the corona after large-scale eruptions.
Aims. We study the recovery of dimmings on different spatial scales to enhance our understanding of the replenishment and dynamics of the corona after CMEs.
Methods. In order to investigate the long-term evolution of coronal dimming and its recovery, we propose two approaches that focus on both the global and the local evolution of dimming regions: the fixed mask approach and the pixel boxes approach. We present four case studies (September 6, 2011; March 7, 2012; June 14, 2012; and March 8, 2019) in which a coronal dimming is associated with a flare/CME eruption. We analyzed each event with the same methodology, using extreme-ultraviolet filtergrams from the Solar Dynamics Observatory’s Atmospheric Imaging Assembly (SDO/AIA) and Solar TErrestrial RElations Observatory’s Extreme UltraViolet Imager (STEREO/EUVI) instruments. We identified the dimming region by image segmentation, then restricted the analysis to a specific portion of the dimming and tracked the time evolution of the dimming brightness and area. In addition, we study the behavior of small subregions inside the dimming area, of about 3 × 3 pixels, to compare the recovery in different regions of the dimming.
Results. Three out of the four cases show a complete recovery 24 hours after the flare/CME eruption. The primary recovery mechanism identified in the observations is the expansion of coronal loops into the dimming region. The recovery of the brightness follows a two-step trend, with a steeper and quicker segment followed by a slower one. In addition, some parts of the dimming, which may be core dimmings, are still present at the end of the analysis time and do not recover within 3 days, whereas the peripheral regions (secondary dimmings) show a full recovery.
Conclusions. The high temporal and spatial resolution of SDO/AIA observations combined with multi-view data of the STEREO/EUV instrument reveal high-situated coronal loops expanding after CME eruptions, which cover dimming regions and gradually increase their intensity. Our developed approaches enable the analysis of dimmings alongside these bright structures, revealing different timescales of recovery for core and secondary or twin dimming regions. Combined with magnetic field modeling, these methods lay the foundation for further systematic analysis of dimming recovery and enhance the knowledge gained from already-analyzed events.
L’inouï des cliniques de l’extrême ou la « seconde vie » de la psychanalyse freudienne
Authors: Schwalbe Nicolas 
Published: October 2024

En prenant comme point de départ le concept philosophique de “seconde vie” inventé par le philosophe-sinologue François Jullien ainsi que les travaux de Michèle Benhaïm sur la clinique sociale, cet article détaille comment de nouvelles pratiques cliniques auprès de sujets vivants en grande précarité contribuent à la réinvention de la psychanalyse freudienne en tant que technique thérapeutique et en tant que discours scientifique. En s’appuyant sur le dialogue qu’Olivier Douville a eu avec François Jullien, cet article explore également comment le concept d’inouï associé à un référentiel anthropologique en situation clinique permet d’apporter des éclairages aussi bien éthiques et politiques qu’épistémologiques et techniques aux cliniciens qui vivent au contact de la grande précarité dans leurs milieux de travail. Enfin, cet article se conclut avec un récit qui vise à illustrer comment deux concepts opératoires, la « fiction théorique » et le(s) « geste(s) et souffle(s) d’erre(s) », seraient à même de participer à une ré-invention littérale de la psychanalyse freudienne. Cet article a été écrit dans le cadre d’une participation au programme collectif de recherches « F. Deligny et le pratiques cliniques contemporaines » mené par Derek Humphreys (Professeur des Universités-HDR, Paris-Cité) et financé par la Maison des Sciences de l’Homme (MSH) Paris-Nord.
Contrat territorial de Santé Mentale, topologie existentielle et transfert
Authors: le Carpentier Michel 
Published: October 2024

En France, les doctrines étatiques organisationnelles actuelles de compensation inclusive et d’accompagnement d’un handicap pour les personnes souffrant de psychose rendent très difficile l’articulation dynamique entre thérapeutique active et insertion sociale. La segmentation entre le champ sanitaire et le champ social, et les doctrines d’incurabilité qui lui sont sous-jacentes mettent à mal la citoyenneté de plein exercice des patients permettant un accès continu aux soins actifs visant un processus thérapeutique. La clinique de la Borde fondée en 1953 par le docteur Jean Oury n’échappe pas à ce clivage, l’établissement ayant l’obligation de se situer dans les nouvelles organisations territoriales visant la psychiatrie via le champ de l’organisation de la Santé Mentale dans le territoire du département de Loir-et-Cher. Dans ce contexte, l’enjeu thérapeutique est de poursuivre auprès de chaque personne souffrant de psychose un accueil singulier en leur proposant une thérapeutique de soins actifs veillant pour chacune d’entre elles à articuler individuellement soins actifs et citoyenneté de plein exercice dans la cité.
La possibilité du champ associatif 1901 intégré par la psychothérapie institutionnelle comme espace singulier de responsabilisation de chaque personne indépendamment de son statut offre la possibilité d’un processus singulier d’inscription dans un champ collectif qui donne sens à la participation de chacune. Dans l’exercice de sa liberté de circulation, l’articulation de la thérapeutique et l’insertion tisse une possibilité de reprise existentielle personnelle au long cours sans trop de risque de catastrophe pathologique.
Einstellung zur Insulinpumpentherapie bei Menschen mit Typ-1-Diabetes sechs Monate nach Umstellung im Vergleich zu mehrfach täglichen Insulininjektionen – Eine Beobachtungstudie
Authors: Hermanns Norbert , Ehrmann Dominic , Kulzer Bernhard , Kalt Lucas , Seufert Jochen 
Published: October 2024

Zusammenfassung
Hintergrund Obwohl die Insulinpumpentherapie (CSII) derzeit im Vergleich zur Insulininjektionstherapie eine deutlich physiologischere Methode der Insulinsubstitution darstellt, wenden in Deutschland im Vergleich zu anderen Ländern weniger Menschen mit einem Typ-1-Diabetes diese Therapieform an. Eine Bedeutung könnten hierbei psychologische Faktoren wie Erwartungen und Einstellungen gegenüber einer Insulinpumpentherapie zukommen. In dieser nicht-interventionellen Beobachtungsstudie wurden die Einstellungen zur Insulinpumpentherapie erwachsener Insulinpumpenträger 6 Monate nach Neueinstellung mit Erwachsenen mit einer mehrfachen täglichen Insulininjektionstherapie (MDI) verglichen.
Methoden Einstellungen zur CSII-Therapie wurden mit dem Insulin Pump Attitudes Questionnaire (IPA-Q) erfasst, sowohl bei Teilnehmern der YES-Studie, einer nicht-interventionellen Post Market Surveillance Study zur Effektivität und Sicherheit der mylife YpsoPump (ohne Hybrid-Closed-Loop Algorithmus (= CSII-Nutzer), als auch bei MDI-Anwendern der IPA-Q-Evaluierungsstudie.
Ergebnisse Es wurden die Fragebogendaten von n=191 Teilnehmern (CSII-Nutzer: n=81 Teilnehmer der YES-Studie; MDI-Nutzer: n=110 Teilnehmer der IPA-Q Evaluierungsstudie) ausgewertet. CSII-Nutzer, die eine mylife YpsoPump verwenden, standen 6 Monate nach der Neueinstellung oder Umstellung auf eine CSII-Therapie einer solchen signifikant positiver gegenüber als Nutzer einer MDI-Therapie, während gleichzeitig weniger Nachteile der Insulinpumpentherapie berichtet wurden.
Schlussfolgerungen Diese Studie zeigt eine hohe Relevanz psychologischer Faktoren für die Akzeptanz und Implementierung einer Insulinpumpentherapie. Strukturierte Diabetesschulungen für Menschen mit Typ-1-Diabetes und eine gute technische Einweisung bei Personen, die sich für eine Insulinpumpentherapie entschieden haben, können dazu beitragen, unrealistische Erwartungen und inadäquate negative Einstellungen zur Insulinpumpentherapie abzubauen.
Outcome of Children with Congenital Cytomegalovirus Infection: A Retrospective Observational Study
Authors: Mardegan Chiara , Cao Van Helene , Hanquinet Sylviane , Borradori Tolsa Cristina , Pittet Laure F. , Posfay-Barbe Klara M. 
Published: October 2024

Abstract
Objective Congenital cytomegalovirus (CMV) infection is a common intrauterine infection and the leading cause of nonhereditary sensorineural hearing loss. This study aims to assess the long-term outcome of the infection and to identify infants at risk of developing long-term sequelae.
Methods This retrospective single-center observational study includes infants born between 2003 and 2019 with confirmed congenital CMV (based on current criteria). Brain imaging (ultrasound and magnetic resonance imaging [MRI]), clinical monitoring of neurosensory development, and auditory brainstem evoked responses were performed, as well as long-term neurodevelopmental follow-up to assess sequelae.
Results A total of 66 infants with congenital CMV were included in the study. Median gestational age at birth was 38.6 weeks (interquartile range: 36.9–40.1). Clinical findings included intrauterine growth restriction (39%), microcephaly (29%), thrombocytopenia (17%), and jaundice (11%). Brain abnormalities were observed on ultrasound (30%) and MRI (42%). Neurodevelopmental scores were abnormal in 21 subjects (43%) and associate with the vacuolization of anterior temporal lobe and ventricular septations on MRI (both p = 0.05). Fourteen patients (21%) had sensorineural hearing loss, which was more common in patients with abnormal cerebral images at birth, determined by ultrasound (p = 0.06). Microcephaly (p = 0.05) and abnormal MRI (p = 0.03) at birth were associated with poor long-term outcomes.
Conclusion Early detection of congenital CMV infection is important to prevent long-term complications in affected infants. Understanding the predictors of poor outcomes may help improving management and treatment strategies for this condition.