bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELECTRO-ACUPUNCTURE AT JIANSHI (PC5) AND NEIGUAN (PC6) ALTERS HEART RATE VARIABILITY (HRV) IN FRIGHTENED VOLUNTEERS
Authors: Huang Huanlin , Zhong Zheng , Zhang Xinyi , Wang Jizhou , Li Yujie , Fasmer Ole Bernt , Wik Gustav , Huang Yong , Huang Shaohui 
Published: December 2017

Background: Fear is one of the most widely studied emotions and is closely associated with the autonomic nervous system (ANS). Previous studies have proven that acupuncture directly impacts the ANS, influences the heart rate (HR) and the heart rate variability (HRV) and exerts other effects. The aim of this study was to explore the effect of Jianshi (PC5) and Neiguan (PC6) electro-acupuncture on HRV during fear-invoking auditory stimulation using an Actiheart ECG recorder.
Materials and Methods: Two hundred healthy subjects were recruited. Using a random number table, subjects were grouped for exposure to fear-invoking auditory stimulation (n=40) or neutral auditory stimulation (n=40). After determining that our fear-invoking auditory stimulation produced the fear emotion, the other 120 subjects were similarly divided into an electro-acupuncture (EA group) and a control group that received PC5 and PC6 electro-acupuncture or no intervention.
Results: The fear score of the fear-invoking auditory group was significantly higher than that of the neutral auditory group. The EA group showed higher SD, RMSSD, and high frequency (HF) components of HRV than those of the control group.
Conclusion: The primary result suggests that PC5 and PC6 electro-acupuncture affects cardiac autonomic neural regulation, mainly via the parasympathetic system, in subjects exposed to fear-invoking auditory stimulation.
CAPTURING INDIGENOUS KNOWLEDGE ON MEDICINAL PLANTS USE: CASE STUDY OF SELECTED COMMUNITIES IN OLD OYO NATIONAL PARK, NIGERIA
Authors: Oladeji S.O. , Agbelusi E.A. 
Published: December 2017

Background: Understanding the intricate link between humans and the plants use is needed to address some of to-day’s socio-economic and health challenges.
Materials and Methods: The study focused on plants that have high cultural and medicinal values for the host communities of Old Oyo National Park, Nigeria. Local Knowledge was captured through focus group discussions with herbal vendors, interviews with herbalists as key informants and through field observations. Snowball sampling technique was used in selecting the key informants. Participants selected for the Focus Group Discussion varies with the number of herbal vendors encountered in each commercial market.
Results: In total, 78 medicinal plant species belonging to 39 families including 47 trees, 8 shrubs and 23 herbaceous plants were documented. Forty ailments categorized into thirty one treatments and prevention methods were discovered. Kigellia africana, Cassia spp and Alstonia boonei were used for treating common ailments like malaria, dysentery and gonorrhea. Sources of collecting the medicinal plant species and their mode of administration were different.
Conclusion: The research outcome will contribute to advancement of traditional medicine, resource efficiency and development of new enterprise among the locals. Comprehensive quantitative study of social- economic importance of the medicinal plants is recommended.
IMPROVING EFFECT OF PLATYCODIN D ON ETHANOL-INDUCED FATTY LIVER VIA KEAP1-NRF2-ARE SIGNAL PATH
Authors: Wu Jingtao , Zhou Lei , Yang Guiwen , Tao Fan , Wang Maoshan , Hu Jianguo 
Published: December 2017

Background: Platycodin D (PD) is one of the important active ingredients in the root of the Platycodon grandiflorum
(Jacq.) A. DC (PG), a traditional medicine with many pharmacological activities, especially hepatoprotective activity.
There are some researches on the mechanism of liver protection, but it is not very clear. It is necessary to investigate it
deeply.
Materials and Methods: In order to evaluate the effect of PD on ethanol-induced fatty liver (EFL) and investigate the
possible mechanism, the EFL models of rats and BRL-3A cells were set up and treated with PD of 20, 30 mg/kg body
weight/day for four weeks, respectively. The hepatic histochemistry, liver function enzymes, oxidative stress levels,
antioxidant enzymes and signal path enzymes were assayed.
Results: PD significantly (P
ANTIUROLITHIC ACTIVITY OF BERBERIS TRIFOLIATA EXTRACT ON INDUCED UROLITHIASIS IN RATS BY ZINC DISC IMPLANTATION
Authors: Pérez-Hernández Raymundo Alejandro , Treviño-Moreno Silvia Guadalupe , Arévalo- Martínez Gilberto , Sánchez -García Eduardo , Leos-Rivas Catalina , Rivas-Morales Catalina 
Published: December 2017

Background: In clinical therapy, there is no satisfactory drug available for treatment of urolithiasis, especially for the prevention of their recurrence. The aim of this work was to evaluate in vivo antiurolithic activity of methanolic extract of Berberis trifoliata leaves.
Material and methods: Urolithiasis was induced in Wistar rats by zinc disc implantation in urinary bladder. Upon postsurgical recovery, different doses of the methanolic extract of B. trifoliata leaves (50, 100 and 150 mg/kg body weight) were administered orally to zinc disc implanted rats for a period of 20 days. Antiurolithiatic activity was evaluated by measuring the difference between the weight of the implanted zinc discs at the time of implantation and the final weight of the dried calculi taken out from the bladder at the end of the 20 days period of treatment.
Results: Extract of B. trifoliata significantly reduced calculi deposition around the implanted zinc disc at all doses (50, 100, and 150 mg/kg).
Conclusion: Treatment with methanolic extract of B. trifoliata is useful agent against the kidney stone formation.
MODULATORY EFFECT OF PERIOSTRACUM CICADAE AND BETULAE CORTEX EXTRACTS ON THE ACTIVATION OF ATOPIC DERMATITIS-RELATED ION CHANNELS ORAI1 AND TRPV3
Authors: Nam Joo Hyun , Jung Hyo Won , Kim Woo Kyung , Bae Hyo Sang 
Published: December 2017

Background: The cast-off shells of Cryptotympana pustulata (Periostracum Cicadae, PC) and the bark of Betula
platyphylla (Betulae Cortex, BC) are used as traditional medicines for the treatment of skin diseases. This study was
conducted to investigate the regulatory effects of PC and BC extracts on the activation of the ion channels, calcium
release-activated calcium channel protein 1 (ORAI1) and transient receptor potential cation channel subfamily V
member 3 (TRPV3).
Materials and Methods: Human HEK293T cells, co-overexpressing ORAI1/stromal interaction molecule 1 (STIM1)
or overexpressing TRPV3, were treated with PC or BC extracts at 0.1 mg/mL. The changes in ORAI1 and TRPV3
activities were measured using a conventional whole-cell patch-clamp technique.
Results: PC and BC extracts significantly decreased ORAI1 activation in ORAI1-STIM1 co-overexpressing HEK293T
cells and significantly increased TRPV3 activation in TRPV3 overexpressing cells, compared to that of 2-
aminoethoxydiphenyl borate (2-APB, 100 μM), a known agonist of TRPV3.
Conclusion: Our results suggest that PC and BC extracts have therapeutic potential to improve skin barrier
abnormalities in atopic dermatitis via modulation of ORAI1 and TRPV3 activation.
USE OF DIETARY SUPPLEMENTS FOR WEIGHT LOSS IN OBESE PATIENTS IN ZONGULDAK, TURKEY
Authors: Erdogan Zeynep , Kurtuncu Meltem 
Published: December 2017

Background: Obesity is a prevalent and worldwide health problem . The most common weight loss method preferred by obese individuals is dietary supplements. This study was performed in order to determine the dietary supplements used by obese individuals for weight loss and to examine the barriers to informing health personnel on supplement use.
Materials and Methods: This descriptive study was performed in the Endocrinology and Diabetes Polyclinic at the Endocrinology and Metabolic Diseases Department of the Health Application and Research Center of the Bulent Ecevit University. The sample consisted of 151 patients randomly selected from among the 755 people using the simple randomization method.
Results: In the study, 33.6% of the obese individuals were found to use dietary supplements for weight loss. Women, people with no chronic diseases, people who exercised regularly, and people who underwent regular health check-ups were found to prefer dietary supplements at a greater rate (p
DIURETIC, ANTIDIURETIC AND LAXATIVE ACTIVITIES OF ANTHOCLEISTA VOGELII EXTRACTS IN RATS
Authors: Anyanwua Gabriel O. , Onyeneke Chukwu E. , Ofoha Patricia Chioma , Rauf Khalid , Usunobun Usunomena , Ur-Rehman Nisar 
Published: December 2017

Background: Anthocleista vogelii Planch is a medicinal plant used by traditional healers in the treatment of Malaria, hypertension, ulcer, obesity, diabetes, and as a diuretic and purgative in Africa. Therefore, the present study sought to evaluate the diuretic, antidiuretic and laxative activities of the root bark of A. vogelii extracts and fractions in male Sprague-Dawley rats.
Materials and methods: Sixty rats were placed in 10 groups which included: control (normal saline), furosemide/sodium picosulfate (25 mg/kg) as standard drugs, methanol extracts (250 mg/kg and 500 mg/kg), and 125 mg/kg and 250 mg/kg of saponin, flavonoid and neutral alkaloid fractions of A. vogelii. The drugs/extracts/fractions were administered orally using normal saline as the vehicle.
Results: The 500 mg/kg methanol extracts (ME) significantly increased (p
ETHNOBOTANICAL SURVEY OF MEDICINAL PLANTS USED IN THE MANAGEMENT OF HYPERTENSION IN THE MARITIME REGION OF TOGO
Authors: Gbekley Holaly E. , Karou Simplice D. , Katawa Gnatoulma , Tchacondo Tchadjobo , Batawila Komlan , Ameyapoh Yaovi , Simpore Jacques 
Published: December 2017

Background: Hypertension is one of the most common chronic diseases in modern societies and there is evidence that its incidence and severity are increasing. This survey was conducted to investigate the plants used by the Togolese traditional healers to treat the disease.
Method: From January to June 2016, an ethnobotanical survey was conducted using a semi-structured questionnaire with traditional healers (TH) in the southern region of Togo. The importance of the plants was assessed by the calculation of the use value (UV).
Results: In Total, 128 TH male and female were interviewed and 116 plants species belonging to 46 families were identified as treating hypertension. The most represented families were: Fabaceae with 16 species followed by Euphorbiaceae and Rutaceae contributing with 8 and 6 species respectively. Based on the calculated use values the most important species were Byrsocarpus coccineus Schum. Et thonn. (UV = 0.47); Crateva religiosa G.Forst. (UV = 0.47), Boerhavia diffusa Engelm. &A.Gray L. (UV = 0.47), Xylopia aethiopica A. Rich. (UV = 0.42), Mangnifera indica L. (UV = 0.38). The leaves and the roots were the parts of plant predominantly used to prepare the recipes, mainly decoctions administrated by oral route. Clinical manifestations such as dizzy spells, swarming, loss of consciousness, severe headache, severe anxiety and shortness of breath, nosebleed, and fear of heights were used by TH to diagnose the disease.
Conclusion: This study showed initial evidence of the use of plant materials by Togolese TH to treat hypertension. These results constitute a database for pharmacological screenings with the aim of developing new therapies.
O PERFIL DO PROFESSOR E A POLÍTICA DE FORMAÇÃO CONTINUADA DOS DOCENTES DA UNIPAMPA
Authors: Rhoden Valmor , Rhoden Juliana Lima Moreira 
Published: December 2017

<p>O objetivo do artigo é ampliar a compreensão do perfil do professor do ensino superior brasileiro e das propostas de formação oferecidas dentro do contexto universitário. O foco de estudo foram os professores da Universidade Federal do Pampa e o programa de desenvolvimento profissional desta instituição. A instituição fez parte do programa de expansão das universidades federais no Brasil (REUNI), tem uma estrutura multicampi e suas unidades universitárias estão distribuídas em dez cidades localizadas na região do pampa e fronteira do estado do Rio Grande do Sul. O perfil docente foi construído em consulta ao currículo <em>lattes </em>de 707 docentes (base de corpo docente de 2015) e a proposta de formação continuada para estes professores foi conhecida através dos documentos disponibilizados no site da instituição, referentes à política proposta de formação e desenvolvimento profissional do professor. Tratou-se de um estudo exploratório e descritivo que tiveram os dados sistematizados numa dimensão quanti-qualitativa descritiva. A partir dos dados levantados e analisados foi possível identificar alguns aspectos referentes ao perfil dos professores da Unipampa e compreender como foi se configurando a política de formação continuada nesta universidade. </p>
Structural and Design Evolution of Bio-resorbable Scaffolds: The Journey so Far
Authors: Mishra Sundeep 
Published: December 2017

Background:
Coronary stenting has now become a gold standard to prevent or counteract narrowing
and obstruction of coronary vessels due to disease or injury. While the use of stents has been successful in this
situation, they are not without drawbacks and concerns. Restenosis and stent thrombosis after an interventional
procedure are the dreaded side effects resulting from the body’s natural response to a foreign object in the vasculature.
New developments in drug-eluting stents, such as biodegradable materials could mitigate some of the
problems like stent thrombosis, at least late stent thrombosis.

Methods:
The goal of this work is to identify how the structural and design components of bio-resorbable scaffolds
(BRS) evolved and get translated into clinical outcomes. All the BRS articles were identified by an internet
based search and relevant articles were included in the review.

Results:
The evolution of BRS from concept to current form is examined and the possible future course this field
might turn discussed.

Conclusion:
The BRS field has evolved learning from DES terrain but this technology has its own advantages
and limitations. Newer generation of bio-resorbable scaffolds will be required to replace current generation of
technologically advanced DES.
Patients’ Illness Perceptions of Type 2 Diabetes: A Scoping Review
Authors: Dimova Elena D. , Ward Ashleigh , Swanson Vivien , Evans Josie M.M. 
Published: December 2017

Background:
People’s personal perceptions, or illness representations, of type 2 diabetes can
act as barriers to successful self-management.
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Introduction: Understanding patients’ subjective perceptions of type 2 diabetes can aid the design of
evidence-based care and appropriate educational programmes. This scoping review provides a narrative
account of previous knowledge of patients’ illness representations of type 2 diabetes.

Methods:
Quantitative and qualitative studies that explored patients’ illness representations of type 2
diabetes, as defined by Leventhal’s Common Sense Model, were included.

Results:
Thirty four studies were identified for this review, but only 14 studies were carried out in a
general population of people with diabetes. Illness representations varied across study populations.
While it is clear that the perceptions of ethnic minorities and marginalised groups are embedded in their
historical and cultural backgrounds, it is also important to understand the views of the wider population.

Conclusion:
The review highlights the need for self-management interventions to reflect the target
population’s representations of type 2 diabetes in order to inform interventions and clinical practice.
Improving Water Resistance of Compressed Earth Blocks Enhanced with Different Natural Fibres
Authors: Danso Humphrey 
Published: December 2017

Background:
Studies have shown a great potential for the use of Compressed Earth Blocks (CEBs) as a sustainable building material due to its economic, environmental and social benefits.

Objective:
This study investigates the water resistance characteristics of CEBs reinforced with different natural fibres.

Methods:
The fibres were sourced from coconut husk, sugarcane bagasse and oil palm fruit at 1 wt% added to two soil samples. The CEB specimen size of 290 × 140 × 100 mm was made at a constant pressure of 10 MPa and dried in the sun for 21 days. Accelerated erosion test was conducted to determine the resistance of the specimen to continuous rainfall condition.

Results:
It was discovered that the fibres helped in reducing the erodibility rate of the blocks, though there were some degrees of damage. The difference between the water resistance of the unreinforced and fibre reinforced CEBs were found to be statistically significant. Furthermore, the surface of the fibre reinforced blocks eroded rapidly in depth than the internal part, and there was reduction in the depth difference of the erosion with increase time of water spraying on the specimens.

Conclusion:
The study concludes that though the addition of fibres in soil blocks does not completely prevent the block from erosion, the impact of the fibres on the blocks significantly reduces the erosion.
Адипонектин у больных с сахарным диабетом 2-го типа при нормальной массе тела
Authors: Honcharova O.A. , Partskhaladze V.I. , Illinа I.M. 
Published: December 2017

Установлено, что у больных сахарным диабетом 2-го типа на фоне нормальной массы тела средний уровень адипонектина (АН) в плазме крови, в отличие от больных с избыточной массой тела и ожирением, находится в пределах референтных норм. В то же время примерно у половины из них (54,5 %) уровень АН снижен. Подгруппа со сниженным уровнем АН отличается большим возрастом больных и длительностью диабета, а также повышением уровней триглицеридов и липопротеинов очень низкой плотности, более частым увеличением окружности талии. В то же время у больных сахарным диабетом 2-го типа с нормальной массой тела не выявлено достоверных ассоциативных связей между уровнем АН и показателями углеводного обмена — уровнем глюкозы в крови и инсулина натощак, индексом НОМА-IR.Полученные данные обосновывают необходимость своевременно выявлять и корригировать нарушения липидного обмена у больных сахарным диабетом 2-го типа с нормальной массой тела.
Случай сочетания первичного гиперпаратиреоза с АКТГ-эктопированным синдромом Кушинга
Authors: Rikhsiieva N.T. , Urmanova Yu.M. , Khodzhaieva F.S. 
Published: December 2017

Описан редкий случай сочетания первичного гиперпаратиреоза (ПГПТ) с АКТГ-эктопированным синдромом Кушинга у женщины 37 лет. Пациентке поэтапно были выполнены оперативные вмешательства после компенсации общего состояния: двухсторонняя паратиреоидэктомия, через 4 мес. — удаление карциноидной опухоли легкого. Авторами рекомендовано проводить в случае наличия синдрома Кушинга или ПГПТ тщательное исследование пациентов с целью исключения синдромов МЭН-1 и МЭН-2. Кроме того, следует исключить наличие семейных форм заболевания, то есть необходимо проводить обследование ближайших родственников.
Diseño de un alimento infantil listo para consumir fortificado con hierro a base de arveja (Pisum sativum)
Authors: Villaquirán Zulma , Burbano Paola , Osorio-Mora Oswaldo , Cerón-Cardenas Andrés Felipe , Bucheli-Jurado Mauricio Alexander 
Published: December 2017

Introducción: La deficiencia de hierro es uno de los problemas nutricionales más prevalentes a nivel mundial y afecta principalmente a la población vulnerable como niños menores de 5 años. Los alimentos fortificados de consumo infantil hacen parte de las estrategias de intervención y se elaboran a partir de la mezcla ingredientes como cereales, frutas, leguminosas, entre otros. La arveja, es una leguminosa que puede ser empleada con el fin de aprovechar sus propiedades nutricionales. Objetivo: Diseñar un alimento infantil con arveja (Pisum sativum) listo para consumir, fortificado con hierro e higienizado por pasteurización. Materiales y métodos: Se seleccionó el porcentaje de arveja adecuado en el alimento mediante análisis sensorial. La selección de la sal de hierro se realizó mediante análisis fisicoquímico y sensorial empleando sulfato ferroso y hierro aminoquelado. Posteriormente se evaluó el crecimiento de microorganismos mesófilos con el fin de seleccionar el tratamiento térmico de pasteurización. La evaluación de vida útil se llevó a cabo a través de pruebas sensoriales. Finalmente se realizó la evaluación fisicoquímica, composicional y microbiológica del alimento higienizado. Resultados: La adición de arveja en porcentajes no mayores al 6,5% dentro de la formulación del alimento resultó aceptable para los padres de niños menores de 5 años. Por otra parte la sal seleccionada por generar menos cambios sobre el color y la acidez del alimento durante el almacenamiento fue hierro aminoquelado. Los resultados de tratamiento térmico mostraron que para reducir la concentración inicial de mesófilos y obtener un alimento de buena calidad de acuerdo con la normativa colombiana vigente fue necesario someter el alimento a 85°C durante 13 minutos (0,45 D), con lo que se consiguió mantener la calidad inicial del alimento durante 12 días bajo refrigeración. Conclusiones: El alimento desarrollado cumple con los criterios sensoriales y microbiológicos exigidos en la normativa colombiana vigente y es apto para el consumo, además se puede catalogar como alto en hierro y buena fuente de proteína, aportando el 25% y el 15% de la recomendación diaria en Colombia respectivamente.
Análisis de la asociación entre procalcitonina y mortalidad por sepsis en menores de 18 años en una unidad de cuidados intensivos, Pasto- Colombia 2012 - 2014
Authors: Pantoja-Chamorro Freddy , Mazzillo-Vega Liliana , Palacios-Barahona Uriel 
Published: December 2017

Introducción: La procalcitonina aumenta tempranamente en pacientes con sepsis, sin embargo, es necesario profundizar la relación entre sus niveles y el compromiso multiorgánico, así como sus desenlaces como la muerte. Objetivo: Determinar si existe asociación entre los valores de procalcitonina y la muerte en niños con sepsis que ingresan a cuidado intensivo pediátrico (UCIP). Materiales y métodos: Estudio de corte transversal de pacientes menores de 18 años con sepsis que ingresaron a la UCIP del Hospital Infantil Los Ángeles, Pasto - Colombia, durante 2012 y 2014. Se analizó la relación entre el riesgo de muerte y los niveles de procalcitonina controlando por covariables clínicas y demográficas. Resultados: Se analizaron datos de 325 pacientes con sepsis, la enfermedad mostró una prevalencia de 27,3%, de los cuales fallecieron el 23,7% (77). La edad mediana fue 22 meses, rango intercuartil- RI (6 - 84). La mediana de procalcitonina fue de 10 ng/mL, RI (2,95 - 38). Niños con valores >10ng/mL tienen un incremento del riesgo de muerte de 2 a 6 veces más comparados con aquellos que presentaron valores inferiores. Conclusión: La procalcitonina puede ser utilizada como indicador y predictor del riesgo de muerte en menores de 18 años con sepsis.