bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined interventions for COPD admissions within an urban setting
Authors: Ghosh Sudip , O'Kelly Noel , Roberts Emma-Jane , Barker Chris , Swift Jim 
Published: March 2016

Aims: To evaluate the scale of impact of a combined intervention using telehealth (Clinitouch system) in parallel with clinical health coaching and specialist nurse interventions. This was triggered by biometric data from a redesigned service for patients with chronic obstructive pulmonary disease (COPD). Eligible patients had a history of two or more prior unscheduled COPD admissions in the previous 12 months. Methods: Admissions data from University Hospitals of Leicester NHS Trust and interventions from Leicester Partnership Trust and Totally Health were received from Leicester City Clinical Commissioning Group (LC CCG). Data were analysed relating to the impact on admissions and overall resource use and compared to the previous 12 months with patients acting as their own controls. Results: The number of admissions decreased from 3.13 to 1.02 admissions per patient over the 12-month period (p < 0.001). The overall net saving to the LC CCG over the 12-month period was £117 550. Conclusions: All of the interventions were regressed in isolation and in conjunction, with the exception of telehealth (CliniTouch-Spirit Healthcare), which was accessed uniformly by all participants. Only the overall intervention including telehealth was statistically significant; correlation co-efficient 0.995 (p < 0.001), which indicated a strong correlation between accessing the interventions and reduced hospitalisations. In the analysis of variation, specialist nurse home visits and health coaching interventions, which had variable intensities trended towards significance (p < 0.36 and p < 0.17, respectively). Patient feedback suggested patients were more knowledgeable about their condition, more confident in managing it and motivated to change behaviour in a positive direction as a result of being involved in the intervention.
Within-Tree and Tree-Age Variation of Selected Anatomical Properties of the Wood of Ugandan-Grown Eucalyptus grandis
Authors: Sseremba O. E. , Mugabi P. , Banana A. Y. 
Published: March 2016

Abstract
The challenges of utilizing Eucalyptus grandis thinnings prompted a study into its anatomical properties with the aim of identifying its potential based on the within-tree axial and tree-age variation. Fiber length, fiber diameter, vessel length, vessel diameter, vessel average, ray height, and ray frequency at 3, 6, 9, and 12 years were studied. Axial sample portions at 25, 50, and 75 percent of tree height were collected from western Uganda and prepared for maceration, microtomy, and microscopy. Analysis of variance and Tukey's test were used to obtain axial and tree-age variation. Fiber length (819 to 1,077 μm) decreased axially in higher tree ages of 6, 9, and 12 years and increased with tree age. Fiber diameter (10 to 13.4 μm) varied inconsistently axially and decreased with tree age. Vessel length had no consistent axial pattern but decreased with tree age (338 to 548 μm). Vessel diameter showed higher values at 75 percent and increased with tree age (93 to 138 μm). Vessel average did not vary axially but decreased with tree age (8 to 11 vessels per mm2). Ray height did not vary axially but increased with tree age (107 to 278 μm). Ray frequency decreased with tree age (8 to 10 rays per mm2). E. grandis trees at the ages of 3, 6, 9, and 12 years have anatomical properties suitable for production of strong pulps although with a modest proportion of fines. Comparative research on cloned E. grandis varieties and their implied industrial potential would be appropriate to improve utilization of this fast-growing tree species.
Key Vulnerabilities in the Surgical Environment: Container Mix-Ups and Syringe Swaps Do Not Confuse Idarucizumab with Idarubicin
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: March 2016

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Evaluation of Intravenous Acetaminophen on Length of Stay in Abdominal Surgery Patients
Authors: Madere Tyler C. , Mendez Jennifer B. , Nordmeyer Sarah T. , Heidel R. Eric , Hamilton Leslie A. 
Published: March 2016

Purpose The objective of this study is to evaluate the effect of intravenous acetaminophen on length of stay (LOS) in abdominal surgery patients. Methods This retrospective, cohort chart review evaluated patients who underwent colon resection or pancreaticoduodenectomy between January 1, 2010 and August 31, 2013. The primary outcome is postoperative LOS. Secondary outcomes include opioid use, pain scores, and naloxone or laxative use. Patients who received intravenous acetaminophen were compared to patients who did not. Results A total of 329 patients were included, with 269 in the non-acetaminophen group compared to 60 patients in the acetaminophen group. There was no difference in postoperative LOS (9.2 s vs 9.1 days; P = .90). Postoperative LOS was also similar when controlling for surgery type. The acetaminophen group had reduced opioid consumption in the first 24 hours postoperatively ( P = .02). However, pain scores were higher in the acetaminophen group, both in the first 24 hours ( P = .007) and throughout the hospital stay ( P < .001). Other clinical outcomes were similar between groups. Conclusion Intravenous acetaminophen was not associated with a decreased postoperative LOS at our institution.
Use of Alteplase for Clearing Peritoneal Dialysis Catheter Occlusion
Authors: Pierce Dwayne A. 
Published: March 2016

Background Peritoneal dialysis (PD) catheter complications account for 20% of all transfers from PD to hemodialysis. One complication is outflow obstruction caused by fibrin deposits within the lumen of the catheter. Alteplase is frequently used to clear fibrin deposits in PD catheters that are refractory to other therapies. However, the literature basis for this practice is unclear. Method A review of the literature was conducted to determine the evidence existing for alteplase use in PD catheter occlusion due to fibrin. A literature search of MEDLINE (1967-present) was conducted using the search terms “alteplase”, “peritoneal dialysis catheter”, “occlusion”, “fibrin”, and “tissue plasminogen activator”. Referenced citations were also searched for pertinent material. All data concerning the use of alteplase for peritoneal dialysis catheter occlusion were included in this review. The search resulted in 1 open-label pilot study, 3 case series, and 2 case reports of alteplase use in declotting occluded PD catheters. Results Based on the data, alteplase therapy cleared the occlusion of PD catheters in the majority of cases. In those that were unsuccessful, other surgically correctable and mechanical causes were identified in most cases. Conclusion Alteplase appears to be an intriguing alternative to the surgical removal of the PD catheter in patients with catheter occlusion due to fibrin. Although not inexpensive, it appears safe and may decrease the need for surgical correction of occluded catheters.
The Deadbeat Paternal Effect of Uncapped Sperm Telomeres on Cell Cycle Progression and Chromosome Behavior in Drosophila melanogaster
Authors: Yamaki Takuo , Yasuda Glenn K , Wakimoto Barbara T 
Published: March 2016

Abstract
Telomere-capping complexes (TCCs) protect the ends of linear chromosomes from illegitimate repair and end-to-end fusions and are required for genome stability. The identity and assembly of TCC components have been extensively studied, but whether TCCs require active maintenance in nondividing cells remains an open question. Here we show that Drosophila melanogaster requires Deadbeat (Ddbt), a sperm nuclear basic protein (SNBP) that is recruited to the telomere by the TCC and is required for TCC maintenance during genome-wide chromatin remodeling, which transforms spermatids to mature sperm. Ddbt-deficient males produce sperm lacking TCCs. Their offspring delay the initiation of anaphase as early as cycle 1 but progress through the first two cycles. Persistence of uncapped paternal chromosomes induces arrest at or around cycle 3. This early arrest can be rescued by selective elimination of paternal chromosomes and production of gynogenetic haploid or haploid mosaics. Progression past cycle 3 can also occur if embryos have reduced levels of the maternally provided checkpoint kinase Chk2. The findings provide insights into how telomere integrity affects the regulation of the earliest embryonic cell cycles. They also suggest that other SNBPs, including those in humans, may have analogous roles and manifest as paternal effects on embryo quality.
Morning melatonin ingestion and diurnal variation of short-term maximal performances in soccer players
Authors: Ghattassi K , Hammouda O , Graja A , Boudhina N , Chtourou H , Hadhri S , Driss T , Souissi N 
Published: March 2016

Aim
Very few studies have investigated the temporal specificity of melatonin (MEL) ingestion upon short-term maximal athletic performances. The aim of the present study was to explore the effect of morning MEL ingestion on cognitive and physical performances measured in the afternoon.

Methods
Twelve soccer players from a Tunisian squad (17.9 ± 1.3 years, 1.74 ± 0.06 m and 62.0 ± 8.8 kg) participated in the present study. They performed two testing sessions at 08:00 h, 12:00 h and 16:00 h after either MEL (5mg) or placebo (PLA) ingestion, in a randomized order. During each period, the participants performed the following cognitive and physical tests: reaction time and vigilance tests, medicine-ball throw (MBT), five jumps, handgrip strength (HG), and agility tests.

Results
cognitive and physical performances were significantly higher at 16:00 h compared to 08:00 h during the two conditions (p < 0.05). Moreover, performances of MBT and HG were lower in the morning with MEL in comparison to PLA (p < 0.05). However, MEL ingestion did not affect physical and cognitive performances measured at 12:00 h and 16:00 h.

Conclusion
morning MEL ingestion has no unfavourable effect on afternoon physical and cognitive performances in soccer players.
PEMBERIAN LIMBAH PERKEBUNAN SINGKONG YANG DISUPLEMENTASI SENG DAN KOBALT TERHADAP PERFORMA REPRODUKSI DOMBA BETINA (Utilization of Cassava Plantation Waste Supplemented with Zinc and Cobalton Reproduction Performance of Ewe)
Authors: Hernaman Iman , Hidajat Kundrat , Budiman Atun , Nurachma Siti 
Published: March 2016

The study aimed to evaluate the utilization of cassava plantation waste suplemented with zinc and cobalt on ewe reproduction performance. Six pregnacy ewes were allocated at experimentrations, i.e. K1: control (50% fresh grass + 50% concentrate) and K2: 50% fresh grass + 50% cassava plantation waste + 30 ppm zinc + 5 ppm cobalt. The results showed that the concentration of zinc and cobalt in blood of ewe in group K1 and K1 were 7.03 vs 8.22 ppm and 0.48 vs 0.44 ppm, respectively, while in faeces were 147,72 vs 158.59 ppm and 8.3 vs 9.8 ppm. In addition, the concentration of alkaline phosphatase and progresterone in blood were 116 vs 196 u/l and 0.56 vs 0.59 mg/ml, respectively. The average of offsprings weight on 24 day postpartum in K1 and K2 was 3.48 vs 3.16kg. In conclusion, cassava plantation waste could be used as feed for pregnancy and lactating ewe. Supplementation of 30 ppm zinc is efectively increase the concentration of zinc and alkaline phosphatase in blood.Key words: cobalt, reproduction, cassava, zinc, ewe
APLIKASI FOURIER TRANSFORM INFRARED (FTIR) DAN PENGAMATAN PEMBENGKAKAN GENITAL PADA SPESIES PRIMATA, LUTUNG JAWA (Trachypithecus auratus) UNTUK MENDETEKSI MASA SUBUR
Authors: Sjahfirdi Luthfiralda , Aldi Nikki , Maheshwari Hera , Astuti Pudji 
Published: March 2016

Penelitian ini bertujuan mengetahui gugus fungsi penanda yang merepresentasikaan hormon metabolit E1C dan PdG serta bilangan gelombangnya pada urine yang didukung dengan pengamatan genitalia untuk memastikan pendeteksian masa subur pada lutung jawa (Trachypithecus auratus). Sampel urine dan pengamatan genitalia diperoleh dari 2 (dua) ekor lutung jawa betina di Pusat Primata Schmutzer, Kebun Binatang Ragunan, Jakarta. Sampel urin diambil setiap hari dan dilengkapi dengan pengamatan genitalia. Hasil menunjukkan bahwa gugus fungsi penanda yang merepresentasikan E1C dan PdG pada lutung jawa sama dengan yang teridentifikasi pada tikus namun dengan bilangan gelombang berbeda. Hormon metabolit E1C direpresentasikan melalui gugus fungsi alkil, aromatik, dan hidroksil pada bilangan gelombang 596 cm-1, 698 cm-1, 3599 cm-1, dan PdG direpresentasikan melalui gugus fungsi alkil dan aldehid pada bilangan gelombang 1450 dan 1699 cm-1. Dari penelitian ini dapat disimpulkan bahwa gugus fungsi penanda yang teridentifikasi oleh fourier transform infrared (FTIR) dapat berlaku secara universal, namun bilangan gelombang yang merepresentasikannya bersifat spesifik spesies.
Making Data Pay
Authors: Rassenfoss Stephen 
Published: March 2016

There is talk about digital oil fields and big data and some striking examples of their power. But in real oil fields, a lot of operators are still running fields with systems relying on big paper.
Since retiring from Chevron where he worked on introducing digital oilfield technology, Jim Crompton has advised smaller operators and learned that “80% are operating on paper” and many control systems using established computerized control systems such as SCADA are “the next generation.”
To describe the state of the oilfield technology during a presentation at the recent SPE Digital Energy Conference and Exhibition in The Woodlands, Texas, Crompton, an adviser with Noah Consulting, quoted a well-known science fiction writer, William Gibson, who said, “The future is here, it is just not evenly distributed.”
The speakers at the conference pointed out a widely shared problem for those working in this field: while much data is gathered, little of it is used. For example, about 5% of the real-time data from a drillship are sent to shore to help monitor and control drilling, he said.
At the corporate level, the industry has been a leading user of computer power and advanced analysis methods for engineering and managing the enterprise. Exploration and production (E&P) companies own some of the world’s most powerful supercomputers, which are used to do the seismic studies that are the foundation of reservoir models. But frequently, they are unable to update those models with results from producing fields.
“Analytics is used on an enterprise level, but no one is looking at how to use it on an operational basis so we can run data on models of wells or reservoirs as we gather the data,” said Moray Laing, executive lead consultant for oil and gas at the SAS Institute, during a panel discussion at the conference.
How Ready Is Your Project for Delivering Production?
Authors: Eberspaecher Kai C. , Gabb Jamie W. 
Published: March 2016

Management
In recent years, projects in upstream oil and gas have become more complex, remotely located, and, therefore, costly and difficult to deliver. Research shows that one of the key performance indicators—attainment of production as per the basis of design— is not achieved without significant further investment and significant delay (Merrow 2011). The findings are an industrywide phenomenon. Oil and gas companies have started to think about how to reduce the risk of costly remedial actions to meet original production targets.
There are principally two activities that companies employ to optimize internal processes for better outcomes: (1) strengthening project assurance activities and (2) planning ahead for long-term operations. Recent experience in coal seam gas (CSG) to liquefied natural gas (LNG) projects on the east coast of Australia further enforces these principles.
1. Value assurance fostering system integration
After the late 1990s trend to return to the roots of the E&P sector, after a period of diversification into other businesses, capital discipline was instituted in most large multinational oil and gas companies. The value assurance framework was principally employed to enhance the efficiency of capital invested by offering “more bang for the buck.”
Because of the natural movement of employees and increased pressure from shareholders, capital allocation discipline and value assurance have found widespread application in the industry. Over the years, the same framework expanded to include technical and operational requirements that stipulate minimum standards for deliverables at various stages of project delivery such as concept selection, detailed design, construction, and commissioning.
A key learning in applying these processes was to recognize the large degree of systems interaction that require higher levels of integration. The model developed by Shenhar and Dvir (2007) classifies projects by a number of key variables and attributes certain factors to overcome factors such as uncertainty, complexity, organizational knowledge, and urgency. These factors correlate with the observations in Merrow’s analysis of executed megaprojects (Merrow 2011).
In identifying the key drivers for each project, a different approach, team composition, and organizational setup is required. A good example is the difference between a repeat project rolling out an existing widget in another location to a crisis management project as a response to a natural disaster or an external threat. The sponsors, available resources, and expectations of the two projects will be very different, thus leading to very different approaches and outcomes.
In general, the more complex the project, the higher the level of integration required to achieve project objectives. The lower the level of integration, the more likely that project objectives such as production attainment, budget, or schedule are not achieved.
Studies on Anti-Cancer Activity of Lysyl Oxidase from Trichoderma Viride MTCC 167
Authors: Kalra Shipra , Midha Kanav , Monika - , Kaur Manpreet 
Published: March 2016

Lysyl oxidase produces H2O2 i.e. ROS by acting on L-Lysyine. In the present study, ROS thus produced has been used by in vitro cytotoxicity assay on ovarian cancer cells thereby achieving 250 percent inhibition. Lysyl oxidase activity was determined spectrophotometrically by Dintrophenylhydrazine (DNPH) reagent. For isolation of lysyl oxidase produced by Trichodermaviride, acetone precipitation and ammonium sulphate precipitation was carried out. The effect of temperature on lysyl oxidase production was determined by incubating the media with 1.5 % inoculum at different temperature ranging from 10 , 20, 30,40,50,60,70 , 80 0C for 72 hr . Anti-tumor properties of Lysyl oxidase was checked using Rhodamine assay and NBT Assay. Comparative results for Acetone and Ammonium Sulphate precipitation showed that Enzyme activity(U/ml) of acetone precipitation is 124.6 and 144.3 IU/ml and Protein Content is 1.8 and 2.2 mg/ml with the specific activity 68.4IU/mg and 64.1IU/mg . The optimum enzyme production was found to be at pH 8 and optimum temperature for lysyl oxidase production was 500C with maximum enzyme activity of 0.38 (U/ml). 7th fraction contained highest enzyme activity so the retention time of lysyl oxidase was found to be 7 min. The protein content was also calculated by using Bradford method and it was highest in the 1st fraction and in 6th, 7th and 8th fractions. The specific activity has been improved from 75.1 IU/mg to 86.5 IU/mg. 10 units of lysyl oxidase inhibits 3x104 cells in each well to 82.5% and inhibition achieved at same cell count at 200 units which was 250% as observed with NBT and Rhodamine assay.Int J Appl Sci Biotechnol, Vol 4(1): 57-63
Optimization of bead geometry for duplex stainless steel GTA welds using the Taguchi approach
Authors: Sasidharan R. , Boopathy S. Rajendra , Vijayan S. , Rao S. R. Koteswara 
Published: March 2016

AbstractSingle pass, autogenous flat butt welds were made on 6 mm thick duplex stainless steel (2205) plates using gas tungsten arc welding (GTAW) process. Four of the welding process parameters, i. e., arc current, welding speed, shielding gas flow rate and arc gap, were varied each at four levels and welding trials were conducted as per an L16 orthogonal array derived using the Taguchi methodology. Bead geometry parameters, depth of penetration and aspect ratio (width-to-depth ratio) were measured on polished and etched samples using microstructural image analysis. Tabulated results were subjected to analysis of variance and effects of each parameter on bead geometry were calculated. It has been found that welding current and welding speed are the dominant parameters determining the bead geometry. Gas flow rate also plays a key role in influencing the aspect ratio of the welds. Equations have been presented to predict depth of penetration and aspect ratio of the weld.
Effect of mechanical alloying on FeCrC reinforced Ni alloys
Authors: Yilmaz S. Osman , Teker Tanju , Demir Fatih 
Published: March 2016

AbstractMechanical alloying (MA) is a powder metallurgy processing technique involving cold welding, fracturing and rewelding of powder particles in a high-energy ball mill. In the present study, the intermetallic matrix composites (IMCs) of Ni-Al reinforced by M7C3 were produced by powder metallurgical routes via solid state reaction of Ni, Al and M7C3 particulates by mechanical alloying processes. Ni, Al and M7C3 powders having 100 μm were mixed, mechanical alloyed and the compacts were combusted in a furnace. The mechanically alloyed (MAed) powders were investigated by X-ray diffraction (XRD), microhardness measurement, optic microscopy (OM), scanning electron microscopy (SEM) and energy dispersive spectrometry (EDS). The presence of the carbides depressed the formation of unwanted NiAl intermetallic phases. The mechanical alloyed M7C3 particles were unstable and decomposed partially within the matrix during alloying and sintering, and the morphology of the composites changed with the dissolution ratio of M7C3 and sintering temperature.
Physical and biogeochemical spatial scales of variability in the East Australian Current separation from shelf glider measurements
Authors: Schaeffer Amandine , Roughan Moninya , Jones Emlyn M. , White Dana 
Published: March 2016

Abstract. In contrast to physical processes, biogeochemical processes are inherently patchy in the ocean, which affects both the observational sampling strategy and the representativeness of sparse measurements in data assimilating models. In situ observations from multiple glider deployments are analysed to characterize spatial scales of variability in both physical and biogeochemical properties, using an empirical statistical model. We find that decorrelation ranges are strongly dependent on the balance between local dynamics and mesoscale forcing. The shortest horizontal (5–10 km) and vertical (45 m) decorrelation ranges are for chlorophyll a fluorescence, whereas those variables that are a function of regional ocean and atmosphere dynamics (temperature and dissolved oxygen) result in anisotropic patterns with longer ranges along (28–37 km) than across the shelf (8–19 km). Variables affected by coastal processes (salinity and coloured dissolved organic matter) have an isotropic range similar to the baroclinic Rossby radius (10–15 km).