bluuebunny/crossref_metadata_2025_split huggingface dataset:
An international investigation into O red blood cell unit administration in hospitals: the GRoup O Utilization Patterns (GROUP) study
Authors: Zeller Michelle P. , Barty Rebecca , Aandahl Astrid , Apelseth Torunn O. , Callum Jeannie , Dunbar Nancy M. , Elahie Allahna , Garritsen Henk , Hancock Helen , Kutner José Mauro , Manukian Belinda , Mizuta Shuichi , Okuda Makoto , Pagano Monica B. , Pogłód Ryszard , Rushford Kylie , Selleng Kathleen , Sørensen Claess Henning , Sprogøe Ulrik , Staves Julie , Weiland Thorsten , Wendel Silvano , Wood Erica M. , van de Watering Leo , van Wordragen‐Vlaswinkel Maria , Ziman Alyssa , Jan Zwaginga Jaap , Murphy Michael F. , Heddle Nancy M. , Yazer Mark H. ,   Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Published: August 2017

BACKGROUNDTransfusion of group O blood to non‐O recipients, or transfusion of D– blood to D+ recipients, can result in shortages of group O or D– blood, respectively. This study investigated RBC utilization patterns at hospitals around the world and explored the context and policies that guide ABO blood group and D type selection practices.STUDY DESIGN AND METHODSThis was a retrospective study on transfusion data from the 2013 calendar year. This study included a survey component that asked about hospital RBC selection and transfusion practices and a data collection component where participants submitted information on RBC unit disposition including blood group and D type of unit and recipient. Units administered to recipients of unknown ABO or D group were excluded.RESULTSThirty‐eight hospitals in 11 countries responded to the survey, 30 of which provided specific RBC unit disposition data. Overall, 11.1% (21,235/191,397) of group O units were transfused to non‐O recipients; 22.6% (8777/38,911) of group O D– RBC units were transfused to O D+ recipients, and 43.2% (16,800/38,911) of group O D– RBC units were transfused to recipients that were not group O D–. Disposition of units and hospital transfusion policy varied within and across hospitals of different sizes, with transfusion of group O D– units to non‐group O D– patients ranging from 0% to 33%.CONCLUSIONA significant proportion of group O and D– RBC units were transfused to compatible, nonidentical recipients, although the frequency of this practice varied across sites.
Effects of respiratory muscle work on respiratory and locomotor blood flow during exercise
Authors: Dominelli Paolo B. , Archiza Bruno , Ramsook Andrew H. , Mitchell Reid A. , Peters Carli M. , Molgat‐Seon Yannick , Henderson William R. , Koehle Michael S. , Boushel Robert , Sheel A. William 
Published: August 2017

New Findings
What is the central question of this study?
Does manipulation of the work of breathing during high‐intensity exercise alter respiratory and locomotor muscle blood flow?

What is the main finding and its importance?
We found that when the work of breathing was reduced during exercise, respiratory muscle blood flow decreased, while locomotor muscle blood flow increased. Conversely, when the work of breathing was increased, respiratory muscle blood flow increased, while locomotor muscle blood flow decreased. Our findings support the theory of a competitive relationship between locomotor and respiratory muscles during intense exercise.

Manipulation of the work of breathing (WOB) during near‐maximal exercise influences leg blood flow, but the effects on respiratory muscle blood flow are equivocal. We sought to assess leg and respiratory muscle blood flow simultaneously during intense exercise while manipulating WOB. Our hypotheses were as follows: (i) increasing the WOB would increase respiratory muscle blood flow and decrease leg blood flow; and (ii) decreasing the WOB would decrease respiratory muscle blood flow and increase leg blood flow. Eight healthy subjects (n = 5 men, n = 3 women) performed a maximal cycle test (day 1) and a series of constant‐load exercise trials at 90% of peak work rate (day 2). On day 2, WOB was assessed with oesophageal balloon catheters and was increased (via resistors), decreased (via proportional assist ventilation) or unchanged (control) during the trials. Blood flow was assessed using near‐infrared spectroscopy optodes placed over quadriceps and the sternocleidomastoid muscles, coupled with a venous Indocyanine Green dye injection. Changes in WOB were significantly and positively related to changes in respiratory muscle blood flow (r = 0.73), whereby increasing the WOB increased blood flow. Conversely, changes in WOB were significantly and inversely related to changes in locomotor blood flow (r = 0.57), whereby decreasing the WOB increased locomotor blood flow. Oxygen uptake was not different during the control and resistor trials (3.8 ± 0.9 versus 3.7 ± 0.8 l min−1, P > 0.05), but was lower on the proportional assist ventilator trial (3.4 ± 0.7 l min−1, P < 0.05) compared with control. Our findings support the concept that respiratory muscle work significantly influences the distribution of blood flow to both respiratory and locomotor muscles.
Periodic Response of a Timing Belt Drive System With an Oval Cogged
Pulley and Optimal Design of the Pitch Profile for Vibration
Reduction
Authors: Zhu Hao , Zhu Weidong , Hu Yumei , Wang Xuefeng 
Published: August 2017

Abstract
A complete dynamic model of a timing belt drive system with an oval cogged pulley and an auto-tensioner is established in this work. Periodic torsional vibrations of all accessory pulleys and the tensioner arm are calculated using a modified incremental harmonic balance (MIHB) method based on the complete dynamic model. Calculated results from the MIHB method are verified by comparing them with those obtained from Runge–Kutta method. Influences of tensioner parameters and oval pulley parameters on torsional vibrations of camshafts and other accessory pulleys are investigated. A sequence quadratic programing (SQP) method with oval pulley parameters selected as design variables is applied to minimize the overall torsional vibration amplitude of all the accessory pulleys and the tensioner arm in the timing belt drive system at different operational speeds. It is demonstrated that torsional vibrations of the timing belt drive system are significantly reduced by matching belt stretch with speed variations of the crankshaft and fluctuating torque loads on camshafts. The timing belt drive system with optimal oval parameters given in this work has better performance in the overall torsional vibration of the system than that with oval parameters provided by the kinematic model and the simplified dynamic model in previous research.
Exhaust Systems: CO2 Emission Reduction Using Zeolite Catalyst
Authors: Menon Shruti Mohandas , Goudarzi Navid 
Published: August 2017

Air pollution is a leading public health concern that needs to be tackled. About 30% of the total greenhouse gas emissions, such as CO, HC and NOx are due to automobiles. By 2030, the US Department of Transportation aims to reduce light duty vehicle emissions by 18%. This can be achieved by public policy approaches such as implementing emission control norms and performance improvements such as exhaust system design.
In this work, the implementation of a pure Zeolite catalyst to reduce the exhaust CO2 emission of a SI engine is studied theoretically and experimentally. The complete exhaust system including the catalytic converter, muffler, and pipes is modeled in a 3D CAD modeling software, using the engine specifications. Current expensive precious metals in the catalytic converter are replaced with a binding agent along with Zeolite catalyst. The exhaust system is fabricated and the experimental tests are performed at the maximum engine RPM to obtain threshold emission reduction values. The results showed obtaining an emission reduction of CO2 at a lower cost. Furthermore, it is found that employing Zeolite sieves can further reduce the pollutant emission at a similar cost.
Dynamic Model of Supercritical CO2 Brayton Cycles Driven by Concentrated Solar Power
Authors: Berthet Couso Gregory , Barraza Vicencio Rodrigo , Vasquez Padilla Ricardo , Soo Too Yen Chean , Pye John 
Published: August 2017

Supercritical carbon dioxide (sCO2) Brayton cycle is an emerging technology to be used as a power block with concentrated solar power (CSP) systems, tower type, sCO2 Brayton cycle has the potential to be competitive with traditional Rankine steam cycle. Most of the studies have been focused on the steady state analysis of this technology.
This research has developed numerical models for five configurations of sCO2 Brayton cycles operating under quasi steady state conditions. The studied cycles are connected directly to the solar central receiver tower, which is used to provide heat input to the cycles; consequently, the heat addition is changing over time as a function of solar radiation. During the off load operation, the mass flow rate of the cycle is changing with the goal of keeping the turbine inlet temperature at 700°C. The compressor and turbine use a partial load model to adjust velocities according to the new mass flow rate. Also, the heat exchangers effectiveness are adjusted as they present off-design operation. In the recompression cycle, the model permits to explore the relationship between recompression fraction and the ambient temperature. It is demonstrated that the power generated by the cycle may be improved more than 6 % if the recompression fraction is continuously changed and controlled as a function of the ambient temperature.
Dispatchable Solar Combined Cycle
Authors: Conlon William M. 
Published: August 2017

Successful deployment of large amounts of renewable solar and wind energy has created a pressing need for significant additions of grid connected energy storage. Excess renewable generation is increasingly necessitating curtailment or derating of renewable or conventional generators. The CAISO Duck Curve [8] illustrates the challenge caused by very large quantities of solar generation. Both large scale energy storage and flexible ramping are needed for renewable resources to be financially sustainable and to meet CO2 reduction goals.
The Dispatchable Solar Combined Cycle (DSCC) integrates Concentrating Solar Power (CSP) with Thermal Energy Storage (TES) in a holistic combined cycle configuration to meet the challenges of the CAISO Duck Curve by delivering flexible capacity with dispatchable solar power. Energy cost from DSCC is comparable to that from a Combined Cycle Power Plant (CCPP), and substantially below the alternatives: Photovoltaic plus battery or Photovoltaic plus combustion turbine. DSCC also enable far higher integration of renewable power and far larger renewable capacity factors than the Integrated Solar Combined Cycle (ISCC), which typically has no storage.
The innovative DSCC system:
• uses energy storage to deliver power when it is most valuable,
• increases the capacity factor to deliver more renewable energy,
• improves the power plant Heat Rate to reduce fuel consumption, and
• reduces the cost of power while addressing RPS and storage mandates.
In DSCC, the CSP and TES are used primarily for latent heat: the evaporation of steam, and the Combustion Turbine (CT) exhaust gas is used primarily for sensible heating, especially superheating steam. This simplifies the integration of low-cost storage media, such as paraffinic oils or concrete, instead of molten salt, since high temperature storage is not needed. A single pressure, non-reheat steam cycle suitable, allowing for simplicity of design and operation, reducing costs and facilitating faster startup and ramping.
With DSCC, the steam turbine generates about the same power as the CT, unlike a typical CCPP where about half the power comes from the steam cycle. The additional steam production reduces the Heat Rate about 25% compared to CCPP.
The DSCC approach is ideally suited for repowering existing CSP plants, to provide firm capacity that can dispatch at valuable evening peak periods, increase the power output, and reduce fossil fuel use compared with conventional CCPP or peaking plants.
This paper will outline the DSCC concept, and provide performance estimates for a reference plant.
Techno-Economic Comparison of Solar-Driven SCO2 Brayton Cycles Using Component Cost Models Baselined With Vendor Data and Estimates
Authors: Carlson Matthew D. , Middleton Bobby M. , Ho Clifford K. 
Published: August 2017

Supercritical carbon dioxide (sCO2) Brayton power cycles have the potential to significantly improve the economic viability of concentrating solar power (CSP) plants by increasing the thermal to electric conversion efficiency from around 35% using high-temperature steam Rankine systems to above 45% depending on the cycle configuration. These systems are the most likely path toward achieving the Department of Energy’s (DOE) Office of Energy Efficiency and Renewable Energy (EERE) SunShot targets for CSP tower thermal to electric conversion efficiency above 50% with dry cooling to air at 40 °C and a power block cost of less than 900 $/kWe. Many studies have been conducted to optimize the performance of various sCO2 Brayton cycle configurations in order to achieve high efficiency, and a few have accounted for drivers of cost such as equipment size in the optimization, but complete techno-economic optimization has not been feasible because there are no validated models relating component performance and cost.
Reasonably accurate component cost models exist from several sources for conventional equipment including turbines, compressors, and heat exchangers for use in rough order of magnitude cost estimates when assembling a system of conventional equipment. However, cost data from fabricated equipment relevant to sCO2 Brayton cycles is very limited in terms of both supplier variety and performance level with most existing data in the range of 1 MWe power cycles or smaller systems, a single completed system around 7 MWe by Echogen Power Systems, and numerous ROM estimates based on preliminary designs of equipment for 10 MWe systems. This data is highly proprietary as the publication of individual data by any single supplier would damage their market position by potentially allowing other vendors to undercut their stated price rather than competing on reduced manufacturing costs.
This paper describes one approach to develop component cost models in order to enable the techno-economic optimization activities needed to guide further research and development while protecting commercially proprietary information from individual vendors. Existing cost models were taken from literature for each major component used in different sCO2 Brayton cycle configurations and adjusted for their magnitude to fit the limited vendor cost data and estimates available. A mean fit curve was developed for each component and used to calculate updated cost comparisons between previously-reviewed sCO2 Brayton cycle configurations for CSP applications including simple recuperated, recompression, cascaded, and mixed-gas combined bifurcation with intercooling cycles. These fitting curves represent an average of the assembled vendor data without revealing any individual vendor cost, and maintain the scaling behavior with performance expected from similar equipment found in literature.
Draft Genome Sequence of
Pacificimonas aurantium
Type Strain JLT2012, Isolated from the Seawater of the Pacific Ocean
Authors: Tang Guangrong , Cui Rong , Tian Yu , Lin Xiaopei 
Published: August 2017

ABSTRACT

Type strain JLT2012 was isolated from the southeastern Pacific. Here, we report the draft genome sequence and the initial findings from a preliminary analysis of strain JLT2012, which represents a novel species and should be classified in the existing genus
Pacificimonas
.
Draft Genome Sequences of 10 Environmental Pseudomonas aeruginosa Strains Isolated from Soils, Sediments, and Waters
Authors: Shrestha Shailab D. , Guttman David S. , Perron Gabriel G. 
Published: August 2017

ABSTRACT

Pseudomonas aeruginosa
is an important opportunistic pathogen that has the ability to grow in a range of environmental niches. Here, we report the draft genome sequences of 10 environmental strains of the bacterium isolated from soils, sediments, and waters in various locations in North America and South Africa.
Complete Genome Sequence of the Yogurt Isolate Lactobacillus delbrueckii subsp.
bulgaricus
ACA-DC 87
Authors: Alexandraki Voula , Kazou Maria , Pot Bruno , Tsakalidou Effie , Papadimitriou Konstantinos 
Published: August 2017

ABSTRACT

Lactobacillus delbrueckii
subsp.
bulgaricus
is widely used in the production of yogurt and cheese. In this study, we present the complete genome sequence of
L. delbrueckii
subsp.
bulgaricus
ACA-DC 87 isolated from traditional Greek yogurt. Whole-genome analysis may reveal desirable technological traits of the strain for dairy fermentations.
Draft Genome Sequence of the Anoxygenic Phototrophic Bacterium Phaeospirillum fulvum MGU-K5
Authors: Ivanovsky Ruslan N. , Keppen Olga I. , Lebedeva Natalia N. , Beletsky Aleksey V. , Mardanov Andrey V. , Grouzdev Denis S. 
Published: August 2017

ABSTRACT

Phaeospirillum fulvum
MGU-K5 is an anoxygenic, purple, photoheterotrophic, nonsulfur alphaproteobacterium. Unlike most purple nonsulfur bacteria, MGU-K5 is unable to grow aerobically under chemoorganotrophic conditions. Here, we present the draft genome sequence of
P. fulvum
to provide insights into its physiology.
Complete Genome Sequence of Vitreoscilla filiformis (ATCC 15551), Used as a Cosmetic Ingredient
Authors: Contreras Sandy , Sagory-Zalkind Pierre , Blanquart Hélène , Iltis Agnès , Morand Stanislas 
Published: August 2017

ABSTRACT

We report the first complete genome sequence of a
Vitreoscilla filiformis
strain (ATCC 15551) that is used in the cosmetic industry as
Vitreoscilla
ferment. The assembled genome consisted of one chromosome and two plasmids. These data will provide valuable information and important insights into the physiology of this filamentous organism.
Telementoring with project ECHO: a pilot study in Europe
Authors: Ní Cheallaigh Clíona , O’Leary Aisling , Keating Shay , Singleton Aileen , Heffernan Sheila , Keenan Eamon , Robson Lisa , Sears Jess , Moloney John , Arora Sanjeev , Bergin Colm , Norris Suzanne ,   On behalf of the Irish Hepatitis C Outcomes Research Network
Published: August 2017

The Extension of Community Healthcare Outcomes (ECHO) project is a novel educational intervention designed in New Mexico to transfer subspecialty knowledge about hepatitis C virus (HCV) to primary care providers, thereby increasing patient access to HCV care. The ECHO model has been shown to deliver educational benefits and to result in good treatment outcomes for HCV-infected individuals in the USA; however, this approach has not been assessed in a European setting.We sought to evaluate the feasibility, acceptability and implementation of the ECHO model in Ireland using a pilot study. We present a descriptive review of recruitment, participation, retention and cost of the intervention as well as a qualitative review of the views of participants on the barriers, benefits and acceptability of the ECHO model. In the original Project ECHO in New Mexico, geographical distance posed the greatest barrier to accessing HCV care. In Ireland, people who inject drugs (PWID) were identified by interviewees as the main group facing barriers to accessing specialist HCV care. State-employed doctors and nurses caring for large numbers of HCV-infected PWID in opiate substitution treatment centres and homeless hostels were successfully recruited to participate in the project. Self-employed general practitioners did not participate, due mainly to a lack of time and the absence of reimbursement for participation. Practitioners who participated in the pilot reported benefits to themselves and their patients and would like to continue to participate in similar multidisciplinary, multisite educational interventions in the future.
Associations of fibroblast growth factor 23, vitamin D and parathyroid hormone with 5-year outcomes in a prospective primary care cohort of people with chronic kidney disease stage 3
Authors: Shardlow Adam , McIntyre Natasha J , Fluck Richard J , McIntyre Christopher W , Taal Maarten W 
Published: August 2017

ObjectivesVitamin D deficiency, elevated fibroblast growth factor 23 (FGF23) and elevated parathyroid hormone (PTH) have each been associated with increased mortality in people with chronic kidney disease (CKD). Previous studies have focused on the effects of FGF23 in relatively advanced CKD. This study aims to assess whether FGF23 is similarly a risk factor in people with early CKD, and how this risk compares to that associated with vitamin D deficiency or elevated PTH.DesignProspective cohort study.SettingThirty-two primary care practices.ParticipantsOne thousand six hundred and sixty-four people who met Kidney Disease: Improving Global Outcomes (KDIGO) definitions for CKD stage 3 (two measurements of estimated glomerular filtration rate (eGFR) between 30 and 60 mL/min/1.73 m2at least 90 days apart) prior to study recruitment.Outcome measuresAll-cause mortality over the period of study follow-up and progression of CKD defined as a 25% fall in eGFR and a drop in GFR category, or an increase in albuminuria category.ResultsTwo hundred and eighty-nine participants died during the follow-up period. Vitamin D deficiency (HR 1.62, 95% CI 1.01 to 2.58) and elevated PTH (HR 1.42, 95% CI 1.09 to 1.84) were independently associated with all-cause mortality. FGF23 was associated with all-cause mortality in univariable but not multivariable analysis. Fully adjusted multivariable models of CKD progression showed no association with FGF23, vitamin D status or PTH.ConclusionsIn this cohort of predominantly older people with CKD stage 3 and low risk of progression, vitamin D deficiency and elevated PTH were independent risk factors for all-cause mortality but elevated FGF23 was not. While FGF23 may have a role as a risk marker in high-risk populations managed in secondary care, our data suggest that it may not be as important in CKD stage 3, managed in primary care.Trial registration numberNational Institute for Health Research Clinical Research Portfolio Study Number 6632.