bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Self-Sustainable Communities Economically Viable?: A Financial Analysis of Self-Sustainable Communities
Authors: Manthena Pranava , Singh Gopal 
Published: October 2024

Abstract
Sustainable energy is the new hot topic, and with it comes the conversation of self-sustainable communities. Society is currently neck deep in carbon emissions and pollution, and our current generation is constantly looking for solutions that can reduce our carbon footprint. The housing market is also experiencing a major price hike, with more than 80% of metro areas witnessing home prices increase in the last year. These major problems necessitate a solution, and fast. The most popular solution to these global issues is self-sustaining communities. Self-sustainable communities are groups of localized people off the grid that strive to meet the necessities required for survival (food, water, shelter, energy, etc.) without having to rely on external sources. These communities are able to fully thrive by themselves without the need for any outside intervention. Self-sustainable communities have long been seen as the best way to achieve sustainable, affordable living due to the long-term benefits that they can provide. However, are these communities economically viable in the short term? In this paper, we aim to unveil the curtains on the short-term economic viability and impact of self-sustained communities. We offer a deep analysis of the business aspects that go into creating a self-sustaining community, including cost breakdowns, sharing economy models, and market analysis. We conclude with whether or not self-sustained communities are economically viable in the short run, and also provide ways to fix or enhance potential problems with self-sustaining communities. Our hope is to expose the economical side of developing a self-sustaining community and inform the general public on what could potentially be the best solution to our current climate change crisis and housing deficit.
A single immunization of
Borreliella burgdorferi
-infected mice with Vanguard crLyme elicits robust antibody responses to diverse strains and variants of outer surface protein C
Authors: Chambers Gavin Z. , Chambers Kathryn M. F. , Marconi Richard T. 
Published: October 2024

ABSTRACT

Lyme disease, caused by
Borreliella burgdorferi
and related species
,
is a growing health threat to companion animals across North America and Europe. Vaccination is an important preventive tool used widely in dogs living in, or near, endemic regions. In this report, we assessed anti-outer surface protein (Osp) A and anti-OspC antibody responses in
B. burgdorferi
-infected and -naïve mice (C3H/HeN) after immunization with a murine-optimized single dose of the Lyme disease subunit vaccine, Vanguard crLyme. crLyme is comprised of OspA and an OspC chimeritope-based immunogen designated as CH14. Mice that were infected and immunized developed higher levels of anti-OspC antibodies (Abs) than those infected only or that received one vaccine dose. The anti-OspC Abs that developed in the infected/immunized mice bound to all OspC variants tested (
n
= 22), whereas OspC Abs in serum from infected mice bound predominantly to the OspC variant (type A) produced by the infecting
B. burgdorferi
strain. Consistent with the absence of OspA expression in infected mammals, none of the infected mice developed Abs to OspA and did not develop anti-OspA Abs after single dose immunization. Lastly, serum from infected/immunized mice displayed significantly higher and broader killing activity than serum from non-immunized infected mice. The results of this study demonstrate that a single vaccination of actively infected mice results in strong anti-OspC Ab responses. This study contributes to our understanding of Ab responses to vaccination in actively infected mammals.
Draft genome sequences of four plant-associated free-living diazotrophs isolated from the rhizosphere of Malian tomato
Authors: Bellotti Gabriele , Sanou Paul , Sunzini Piero , Tabaglio Vincenzo , Cocconcelli Pier Sandro , Puglisi Edoardo 
Published: October 2024

ABSTRACT

This announcement reports the draft genome sequences of two
Azospirillum argentinense
and two
Azotobacter salinestris
isolated from the rhizosphere of a tomato plant grown in a village in the Republic of Mali. These strains are plant growth-promoting rhizobacteria and are highly valuable to agriculture for their ability to fix atmospheric nitrogen.
Complete genome sequence of the
Sphingobacterium bambusae
type strain KACC 22910
T
Authors: Kim Do-Hyun , Choi Hyorim , Heo Jun 
Published: October 2024

ABSTRACT

We report the whole genome sequence of
Sphingobacterium bambusae
KACC 22910
T
. The complete genome consists of a 5.6 Mb circular chromosome with a G + C content of 44.4 % and 4,526 predicted coding genes.
Draft genome sequence of
Methyloversatilis
sp. strain NSM2, isolated from a wastewater treatment plant
Authors: Aranda Alicia , Primo-Catalunya David , Pijuan Maite , Balcázar José L. 
Published: October 2024

ABSTRACT

Here, we report the draft genome sequence of
Methyloversatilis
sp. NSM2, isolated from a wastewater treatment plant. This strain was enriched using methane as the sole carbon source. The 4.5-Mb genome, with a GC content of 66.5%, provides valuable insights into the strain’s ecological role and metabolic capabilities.
Association between feels-like temperatures and injury risk during international outdoor athletic championships: a prospective cohort study on 29 579 athlete starts during 10 championships
Authors: Edouard Pascal , Dandrieux Pierre-Eddy , Klöwer Milan , Junge Astrid , Racinais Sébastien , Branco Pedro , Hollander Karsten , Navarro Laurent 
Published: October 2024

ObjectiveTo analyse associations between feels-like temperatures measured with the universal thermal climate index (UTCI) and injury rates during international athletic championships.MethodsDuring 10 international outdoor athletic championships from 2007 to 2022, in-competition injuries were collected by medical teams and local organising committees. UTCI was extracted hourly from a global reanalysis of observed atmospheric conditions during each championship. We performed Poisson regressions with incidence rates (number of injuries per 1000 athlete starts) as outcomes and UTCI as a predictive variable adjusted for sex, for all and time-loss injuries, for different injured tissue types (ie, muscle, tendon, ligament, articular, bone and skin) and specific discipline (ie, sprints, hurdles, jumps, throws, middle distance, long distance, marathon and race walking).ResultsA total of 1203 in-competition injuries were reported for 29 579 athlete starts. For all in-competition injuries (ie, all injured tissue types and all disciplines), higher UTCI was associated with lower incidence rates for time-loss injuries (IRR=0.98, 95% CI 0.97 to 0.98) but not for all injuries (IRR=1.00, 95% CI 1.00 to 1.01). Based on injured tissue type with all disciplines included, higher UTCI was associated with lower incidence rates for all (IRR=0.97, 95% CI 0.97 to 0.98) and time-loss (IRR=0.96, 95% CI 0.96 to 0.96) muscle injuries. Based on the specific discipline, higher UTCI was associated with lower incidence rates for all and time-loss muscle injuries for sprints (IRR=0.95, 95% CI 0.95 to 0.96, and IRR=0.94, 95% CI 0.93 to 0.94, respectively), hurdles (IRR=0.97, 95% CI 0.96 to 97, and IRR=0.95, 95% CI 0.94 to 0.96, respectively) and throws (IRR=0.97, 95% CI 0.97 to 0.98).ConclusionsHigher feels-like temperatures were associated with a decreased risk of time-loss and muscle injuries, particularly in sprints, hurdles and throws. Although the precise mechanism for lower injury rates with higher feels-like temperatures requires further investigation, adapting preparations such as warm-up or clothing to forecasted weather conditions may be of benefit.
Thinking differently: lessons learned by international public health specialists while supporting the Integrated Disease Surveillance and Response system in Pakistan
Authors: Wilson Anne , Cartwright Christopher 
Published: October 2024

Internationally supported activities to build public health capacity and improve compliance with International Health Regulations (2005) so that countries are better able to ‘
prevent, protect against, control and provide a public health response to the international spread of disease
’ have had a positive impact in recent years. However, despite the proliferation of technical guidance, tools and roadmaps, as the recent COVID-19 emergency demonstrates, a significant challenge still remains. The unique and complex environment within countries is increasingly being recognised as a factor which needs greater consideration if system strengthening activities are to be successful.

This paper reflects on the learning from and charts out the journey of the authors’ in their efforts to support the Pakistan government to improve compliance with International Health Regulations, specifically through strengthening its Integrated Disease Surveillance and Response (IDSR) system.
To effect change, public health technical specialists bring their grounded technical and scientific expertise along with their softer public health skills of, among other things, relationship building and multisector working. In the authors’ experience, the importance of taking time throughout to build and maintain strong trusted relationships and peer-to-peer support has been the key to the successes experienced. The nature of this relationship and ongoing reflexive dialogue enabled the co-construction of the reality of the background environment, which, in turn, led to more realistic visioning of the desired system for IDSR, and therefore more appropriate bespoke technical support to be given, leading to the design and initial implementation of a country owned system developed with sustainability in mind.
A century of medical records reveal earlier onset of the malaria season in Haut-Katanga induced by climate change
Authors: Mariën Joachim , Mukomena Eric , Tevuzula Vivi Maketa , Leirs Herwig , Huyse Tine 
Published: October 2024

BackgroundDespite worldwide efforts to eradicate malaria over the past century, the disease remains a significant challenge in the Democratic Republic of the Congo (DRC) today. Climate change is even anticipated to worsen the situation in areas with higher altitudes and vulnerable populations. This study in Haut-Katanga, a highland region, aims to evaluate the effectiveness of past control measures and to explore the impact of climate change on the region’s distinct seasonal malaria pattern throughout the last century.MethodsWe integrated colonial medical records (1917–1983) from two major mining companies (Union Minière du Haut-Katanga and the Générale des Carrières et des Mines) with contemporary data (2003–2020) from Lubumbashi. Concurrently, we combined colonial climate records (1912–1946) with recent data from satellite images and weather stations (1940–2023). We used Generalised Additive Models to link the two data sources and to test for changing seasonal patterns in transmission.ResultsMalaria transmission in Haut-Katanga has fluctuated significantly over the past century, influenced by evolving control strategies, political conditions and a changing climate. A notable decrease in cases followed the introduction of dichlorodiphenyltrichloroethane (DDT), while a surge occurred after the civil wars ended at the beginning of the new millennium. Recently, the malaria season began 1–2 months earlier than historically observed, likely due to a 2–5°C increase in mean minimum temperatures, which facilitates the sporogonic cycle of the parasite.ConclusionDespite contemporary control efforts, malaria incidence in Haut-Katanga is similar to levels observed in the 1930s, possibly influenced by climate change creating optimal conditions for malaria transmission. Our historical data shows that the lowest malaria incidence occurred during periods of intensive DDT use and indoor residual spraying. Consequently, we recommend the systematic reduction of vector populations as a key component of malaria control strategies in highland regions of sub-Saharan Africa.
Feasibility of a theory-based intervention towards benzodiazepine deprescribing in Belgian nursing homes: protocol of the END-IT NH cluster-randomised controlled trial
Authors: Evrard Perrine , Chevallereau Tina , Aikpitanyi Josephine , Pétein Catherine , Tubeuf Sandy , Henrard Séverine , Spinewine Anne 
Published: October 2024

IntroductionDespite several calls to deprescribe benzodiazepine receptor agonists (BZRA) in older adults, their use among nursing home residents (NHRs) remains high. Therefore, we developed an intervention targeting general practitioners’ and healthcare professionals’ behaviours regarding BZRA deprescribing in nursing homes (NHs): The END-IT NH (bENzodiazepines Deprescribing InTerventions Nursing homes) 6-component intervention. Before moving on to a large-scale effectiveness and cost-effectiveness evaluation, this feasibility study aims at: (1) assessing the feasibility of the intervention implementation in NHs, (2) assessing the feasibility of conducting a larger-scale evaluation, in terms of recruitment and data collection and (3) conducting an exploratory cost-effectiveness evaluation.Methods and analysisWe will conduct a cluster-randomised controlled trial in a sample of 6 NHs, with 10–15 NHRs included per NHs. Four NHs will be randomised into the intervention group, and two NHs will deliver usual care (control group). Data collection will occur at baseline, 3, and 6 months (study end). We will collect information to explore implementation fidelity, mechanisms of impact and contextual factors at patient-level, NH-level and healthcare professional-level, using both quantitative and qualitative measures. The feasibility of the study conduction will be assessed by measuring recruitment and attrition rates and completeness of data collection. An exploratory cost-effectiveness evaluation will be conducted based on quality of life and healthcare use and cost data.Ethics and disseminationThis study protocol received approval from the ethical committee of CHU UCL Namur on the 20 June 2023. All data are confidential and will be anonymised prior to analysis. De-identified data will be shared on a data depository with a 2-year embargo. The results of the study will be disseminated through a scientific paper and will be communicated to local stakeholders and policymakers through a local symposium.Trial registration numberNCT05929443.
Physical Activity Elements and Adverse Outcomes in Patients with Chronic Kidney Disease in Guangdong (PEAKING) project: protocol for a prospective cohort study
Authors: Yang Changyuan , Duan Ruolan , Yang Zhenhua , Qiu Jiamei , Pi Minhui , Ling Xitao , Xiao Cuixia , Zeng Jiahao , He Jiawei , Huang Jiasheng , Zhang La , Qin Xindong , Tang Fang , Fu Lizhe , Hou Haijing , Liu Xusheng , Lindholm Bengt , Lu Fuhua , Wu Yifan , Su Guobin 
Published: October 2024

IntroductionPhysical inactivity is prevalent and associated with adverse outcomes among patients with chronic kidney disease (CKD). Most previous studies have relied on subjective questionnaires to assess levels of physical activity (PA) and mainly focused on patients undergoing dialysis. Therefore, the Physical Activity Elements and Adverse Outcomes in Patients with Chronic Kidney Disease in Guangdong study aims to investigate the levels and types of PA elements and their association with adverse outcomes in Chinese non-dialysis CKD (ND-CKD) patients.Methods and analysisIn this prospective cohort study, 374 patients with ND-CKD will be recruited from Guangdong province, South of China. The primary exposure will be levels of PA assessed by ActiGraph GT3X+ accelerometer including the intensity, duration, frequency and type of PA. The traditional Chinese exercises such as tai chi and Baduanjin will also be assessed. The primary outcomes will be all-cause mortality. Other variables including demographics, comorbidities, medication and laboratory markers will be registered. All data will be updated annually for at least 5 years, or until the occurrence of death or initiation of renal replacement therapy. The Spearman correlation coefficient will be used to investigate the correlation between questionnaire-derived and accelerometry-derived PA. The Cox proportional hazards model will be used to investigate the association between level of PA and adverse outcomes. Non-linear associations between PA levels and outcomes, as well as the minimum desirable PA level, will be evaluated using restricted cubic splines.Ethics and disseminationThe ethical permission for this study was obtained from the ethics committee of Guangdong Provincial Hospital of Chinese Medicine in Guangzhou, China (B2015-152-02). Written informed consent is obtained from all participants. The results will be disseminated by publication in a peer-reviewed journal and presented at relevant conferences.
High-flow nasal cannula in adults with chronic respiratory diseases during physical exercise: a systematic review and meta-analysis
Authors: Moya-Gallardo Eduardo , Fajardo-Gutiérrez Jeniffer , Acevedo Karol , Verdugo-Paiva Francisca , Bravo-Jeria Rocío , Ortiz-Muñoz Luis , Contreras-Briceño Felipe , Espinosa-Ramírez Maximiliano 
Published: October 2024

BackgroundChronic respiratory diseases (CRDs) affect at least 545 million people globally, leading to symptoms such as dyspnoea, fatigue and limited physical activity. Pulmonary rehabilitation (PR) programmes aim to improve the exercise capacity and quality of life of patients with CRD through exercise training. High-flow nasal cannula (HFNC) therapy shows potential as an adjunct treatment during exercise, but its effects on CRD populations are unclear. The purpose of this systematic review was to evaluate the effects of HFNC during exercise in people with CRD.MethodsA systematic review was conducted and eight databases and other resources were searched from inception (28 June 2022) to 4 April 2023. Studies that used adult patients with CRD and randomised controlled trial that compared the effect of HFNC versus standard care (conventional oxygen therapy or room air) during exercise were included. Two authors independently selected trials, extracted the data, assessed risks of bias and employed the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach to judging the certainty of evidence. We pooled trials using random-effect models and inverse variance estimation.ResultsSeventeen studies (n=8406) were included in the review (570 patients). The evidence suggests that HFNC increases exercise time after multiple training sessions (weighted mean difference (WMD)=160.58 s; 95% 95% CI=67.32–253.83, 2 studies) and increase after a single session (WMD=72.10 s; 95% CI=28.95–115.24, 11 studies). HFNC may result in little improvements in secondary outcomes (quality of life, dyspnoea, comfort, complications and adherence).DiscussionThe evidence suggests that HFNC may increase functional exercise capacity and positively enhance secondary outcomes. Continued research is justified to elucidate the role of HFNC in PR during exercise training.PROSPERO registration numberCRD42022336263.
Prescribing by level of deprivation in Wales: an investigation of selected medicine groups
Authors: Boldero Richard , Hinchliffe Anne , Griffiths Steven , Haines Kath , Coulson James , Evans Andrew 
Published: October 2024

BackgroundPrescribing is the most common intervention made by healthcare professionals. Our study aimed to compare prescribing between general practitioner (GP) practices with the highest and lowest levels of deprivation.MethodsThe deprivation level of each GP practice was determined using data from the income domain of the Welsh Index of Multiple Deprivation and individual patient postcodes. We compared prescribing data between the highest and lowest deprivation quintiles for selected groups of medicines. The prescribing measures used were selected as the most appropriate to the specific medicine group being considered. Data were analysed across the period of April 2018–March 2023.ResultsFor the medicine groups of statins, hypnotics and anxiolytics, and antidepressants, there was a statistically significantly higher level of prescribing in the highest deprivation quintile. For anticoagulants, there was no significant difference in prescribing between the different quintiles. For hormone replacement therapy, there was a significantly higher level of prescribing in the quintile of lowest deprivation.ConclusionOur study shows variation in the prescribing of different medicine groups between the highest and lowest deprivation quintiles in Wales. Further investigation into this variation is required.
Trends in obesity prevalence by gender and educational level among adults in Mid-Sweden between 2012 and 2022
Authors: Molarius Anu , Karlsson Jan 
Published: October 2024

BackgroundThe aim was to investigate trends in obesity prevalence by gender and educational level in the general population aged 30–69 years, based on large surveys conducted in Mid-Sweden in 2012, 2017 and 2022.MethodsThe study included 22 082, 15 264 and 17 055 respondents, respectively. Obesity (body mass index ≥30 kg/m2) was based on self-reported weight and height. Trends in obesity prevalence, including comparisons across educational levels, were estimated by age-standardised proportions with corresponding 95% CIs. Differences between genders, educational levels and survey years were tested using multiple logistic regression.ResultsThe overall age-standardised prevalence of obesity increased from 17.6% in 2012 to 20.1% in 2017 and to 23.3% in 2022. There was no statistically significant difference in obesity prevalence between men and women. Large and persisting inequalities between educational levels were however observed. In 2022, the prevalence of obesity was about 30% among persons with low/middle education and 18% among persons with high education.ConclusionEfforts to tackle the obesity epidemic are urgently required in Sweden, taking into consideration the circumstances of groups with low and middle levels of education.