bluuebunny/crossref_metadata_2025_split huggingface dataset:
The neural effects of acupuncture for stroke: a protocol for systematic review and meta-analysis based on fMRI
Authors: Cai Shaojie , Zhou Yihao , Yang Siyu , Liu Yichang , Han Yixiao , Wang Dongyan , Shi Shuai 
Published: September 2024

BackgroundStroke is one of the most common causes of death and is the main cause of persistent and acquired disability in adults worldwide. Acupuncture is recommended by the World Health Organization as an alternative and complementary strategy for stroke treatment. However, the mechanism of the neural effects of acupuncture on stroke is still lacking a uniform conclusion. The purpose of this study is to clarify the neural effects of acupuncture for stroke from the perspective of neuroimaging.MethodsSeven databases, including PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, VIP Database, Wan-Fang Data, and Chinese Biomedical Database, will be searched comprehensively according to the search strategy. All of them will be retrieved from the date of database establishment to December 31, 2023. All randomized controlled trials and observational studies will be considered for inclusion. The risk of bias will be assessed by the Cochrane Risk of Bias tool. Functional imaging of the whole brain in the resting functional state will be the primary outcome. A meta-analysis of primary outcome will be performed using Seed-based D Mapping with Permutation of Subject Images software. The data will be synthesized using a random effects model. Meta-analysis of other clinical data will be performed using RevMan 5.3 software. Publication bias will be assessed through funnel plots. Reports will adhere to the Preferred Reporting Items for Systematic Review and Meta-Analysis.ConclusionThis study will aggregate the results of independent studies to provide overall evidence for the neural effects of acupuncture for stroke.Clinical Trial Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=500306, Identifier CRD42024500306.
Characteristics of ear fullness and synaptic loss in ear fullness revealed by SV2A positron emission tomographycortical
Authors: Zhou En , Xiao Xuping , Liu Bin , Tan Zhiqiang , Zhong JiaYu 
Published: September 2024

ObjectiveStudies on feeling of ear fullness (FEF) related to sudden sensorineural hearing loss(SSNHL) are limited. The mechanisms of FEF are unclear. This study aimed to explore the characteristics and related brain activation of SSNHL with FEF.MethodsA total of 269 SSNHL patients were prospectively observed and divided into two groups, with FEF and without FEF. Fifteen SSNHL patients with FEF and 20 healthy controls (HCs) were recruited and underwent 18F-SynVesT-1 static PET. Standardized uptake values ratios (SUVr) of 18F-SynVesT-1 were computed between regions of interest.ResultsThe occurrence of FEF was not related to the audiogram type or severity of hearing loss. There was a positive correlation between the degree of FEF and the degree of hearing loss. Recovery from FEF was not related to the audiogram shape, the degree of hearing loss or recovery. Fifteen SSNHL patients with FEF had relatively low 18F-SynVesT-1 uptake in the right middle frontal gyrus, right inferior frontal gyrus, right middle temporal gyrus, bilateral parietal lobe sub-gyral and left medial frontal gyrus, as compared with HCs. There was no relatively high 18F-SynVesT-1 uptake in the cerebral cortex.ConclusionThe occurrence and recovery of FEF in SSNHL patients are not related to the classification, degree and recovery of hearing loss. The 18F-SynVesT-1 uptake in the cerebral cortex of patients experiencing SSNHL and FEF has shown alterations. This indicates that FEF may be related to cortical reorganization after the sudden impairment of unilateral auditory input.
Progress and challenges in integrated traditional Chinese and western medicine in China from 2002 to 2021
Authors: Zhou Man-Ci , Fei Yu-Tong , Lai Xiao-Zhen , Lan Jian , Liu Bo , Wang Zhi-Wei , Fang Hai , Liu Jian-Ping , Rong Hong-Guo 
Published: September 2024

ObjectiveThe World Health Organization advocated for enhanced integration of traditional medicine and complementary medicine into national healthcare systems across all countries. This study aims to explore the progress and challenges in integrated traditional Chinese and western medicine (ITCWM) in China over 20 years using nationwide data.MethodsThis cross-sectional study examined various facets of ITCWM in China in terms of policies, resources, services, and funding. National policy documents from 2009 onwards were retrieved from official websites of the Chinese government. Data on ITCWM resources, services and subsidies from 2002 to 2021 were extracted from the China Statistical Yearbooks of Chinese Medicine and China Health Statistical Yearbooks. Research fund projects with the ITCWM discipline were collected from the database of National Natural Science Foundation of China. A mixed method of both quantitative and qualitative approaches was employed to present a comprehensive overview of the collected data.ResultsThis study presented five key findings. First, despite the issuance of 17 national policies by the Chinese government since 2009 to promote the development of traditional Chinese medicine (TCM), only three of them were specifically tailored for ITCWM. Second, although the average annual growth rates of ITCWM institutions, beds, and practitioners reached 0.35%, 10.56%, and 10.88% from 2002 to 2021, with more equitable allocation of ITCWM resources, the overall proportion of ITCWM remained below 5% in 2021. Third, progress has been made in ITCWM practices, yet service efficiency requires further enhancement. In 2021, ITCWM hospitals accounted for 2% of outpatient and emergency visits and 1.57% of hospital admissions among all hospitals, and 9.82% of delivered services were preventive healthcare services. Fourth, ITCWM served a crucial role in primary healthcare services, but its service capabilities need improvement. From 2007 to 2021, the average growth rates of ITCWM clinics, outpatient departments, and practitioners in outpatient departments were 13.30%, 2.57%, and 12.14%, respectively, while the proportion within TCM hospitals dropped. Lastly, despite the Chinese government’s emphasis on financial investment and related project funding for ITCWM, it remained lower than that allocated to TCM and western medicine.ConclusionITCWM played a pivotal role in China’s healthcare system to advance individuals’ health and well-being across the lifespan. In the future, China will provide further support to enhance ITCWM health resources and improve service capability, and the strategic integration of ITCWM into the broader healthcare system will play a crucial role in achieving universal health coverage and the Sustainable Development Goals.
Post-activation performance enhancement of flywheel and traditional squats on vertical jump under individualized recovery time
Authors: Sun Shaocheng , Yu Ying , Niu Yu , Ren Meiling , Wang Jiaoqin , Zhang Ming 
Published: September 2024

PurposeTo explore the post-activation performance enhancement (PAPE) of flywheel and traditional squats on a series of vertical jumps, the loads of the two protocols were matched based on their linear velocities. In addition, we attempted to validate the effectiveness of determining individualized recovery time (IRT) between conditioning activities and explosive movements.MethodsSixteen trained players participated in three main experiments: first, one-repetition maximum (1RM) assessment and intensity matching test; second, the weighted jump squat (WJS) test at baseline and at 2, 4, 6, 8, and 10 min after flywheel and traditional protocols; and third, squat jump (SJ), countermovement jump (CMJ), and approach jump (AJ) tests incorporating IRT determined in the WJS sessions into both protocols. These protocols were standardized to 8 repetitions at 80% 1RM with equivalent concentric speed matched by a linear position transducer and conducted in a random order on separate days.ResultsIn the WJS tests, both protocols exhibited significant increases on jump height (JH), peak force (PF), and peak power (PP) after 2 to 6 min (all p &lt; 0.05), and the time courses of changes in performance were in a similar trend. In the SJ, CMJ, and AJ tests, both protocols demonstrated highly significant increases on JH, PP, and reactive strength index (RSI) after incorporating IRT (all p &lt; 0.01), with all participants exhibiting diverse improvement above the baseline levels. The potentiation percentages of the flywheel protocol on JH, PP, and RSI were higher than those of the traditional protocol across four jumping types (JH: 5.35%–9.79% vs. 4.13%–8.46%; PP: 4.16%–6.13% vs. 3.23%–4.77%; and RSI: 7.27% vs. 7.04%).ConclusionHigh-intensity flywheel squats can produce jumping potentiation in neuromechanical factors comparable to, or even surpassing, those observed in traditional squats, potentially making them a more effective option for inducing PAPE. Additionally, incorporating IRT into potentiation protocols could further optimize the PAPE effects.
The relationship between social frailty and cognitive impairment among older adults: the role of various types of internet use
Authors: Choi Kyungwon , Ko Young 
Published: September 2024

IntroductionThis study aimed to explore the role of internet use in the relationship between social frailty and cognitive function among Korean older adults.MethodsA nationally representative survey of community-dwelling older adults in Korea was used in the analysis (N = 8,639).ResultsAll types of internet use were significantly associated with cognitive impairment and played a significant role in the relationship between social frailty and cognitive impairment. The advantage of internet use for information searching (OR 0.40, 95% CI 0.35–0.46) was the greatest for cognitive function, followed by internet use for instrumental use (OR 0.59, 95% CI 0.53–0.66). Internet use for entertainment exhibited the greatest influence in the relationship between social frailty and cognitive impairment, with interpersonal communication ranking second in significance. Internet use regulates the relationship between social frailty and cognitive impairment in older adults. The influences of internet use vary depending on the type of online activity and the levels of social frailty.DiscussionThis highlights the importance of considering various forms of internet use when developing non-pharmacological interventions to mitigate the impact of social frailty on cognitive decline.
Evaluation of dietary supplementation of Ascophyllum nodosum and Lithothamnium calcareum as functional algae in F4+ Escherichia coli challenged piglets
Authors: Dell’Anno Matteo , Frazzini Sara , Reggi Serena , Ferri Irene , Scaglia Elena , Schiasselloni Linda , Inglesi Alessia , Riva Federica , Verdile Nicole , Pasquariello Rolando , Rossi Luciana 
Published: September 2024

IntroductionDespite progress in reducing antimicrobial use in the veterinary field, it is crucial to find alternatives to preserve effectiveness and limit antimicrobial resistance. In pig farming, pathogenic strains of E. coli are the main cause of gastrointestinal disorders and antibiotic use. In this field, algae represent an innovation in animal nutrition that aligns with livestock sustainability principles and provide a high content of functional molecules.AimThe aim of this study was to evaluate the impact of an innovative dietary combination of Ascophyllum nodosum and Lithothamnium calcareum, on growth, duodenum gene expression, jejunum intestinal morphology, and serum oxidative status in F4+ Escherichia coli challenged piglets.Materials and methodsForty-eight weaned pigs, aged 28 ± 2 days, were divided into two groups (n = 24 pigs/group): the control group was fed a commercial diet (CTRL), while the seaweeds group was fed a commercial diet supplemented with 1.5% A. nodosum and 0.5% L. calcareum for 27 days (ALGAE). After 13 days, 50% of animals in each group were challenged with a single dose of 108 CFU/dose of E. coli F4+, resulting in two infected groups (CTRL+ and ALGAE+, n = 12 pigs/group). Growth performance was assessed by measuring the individual body weight. At day 27, from six animals/group duodenum and jejunum sections were sampled for gene expression analysis via qRT-PCR and histological evaluation.Results and discussionThe results indicated a significantly higher body weight in the ALGAE+ group compared to CTRL+ after 7 days post-challenge (p &lt; 0.0001). Jejunum morphology revealed lower villus height, villus width and villus height/crypt depth ratio in CTRL+ compared to ALGAE+ (p &lt; 0.05) suggesting a protective effect of seaweeds on gut health.ConclusionIn conclusion, algae mixture exerted a protective effect against intestinal damage from E. coli F4+ infection proposing A. nodosum and L. calcareum supplementation as interesting strategy to support animal growth, enhance health and reduce antibiotic treatments in weaned piglets.
Emotional and Psychological Safety in Healthcare Digitalization: A Design Ethnographic Study
Authors: Vöcking Mara , Karrenbrock Anne , Beckmann Andreas , Vondeberg Carmen , Obert Laura , Hemming Bernhard , Minartz Peter , Bleck Christian , Cürlis Diana , Kuske Silke 
Published: September 2024

ObjectivesEmotional and psychological safety is important during the use of digital technologies in healthcare. We aimed to gain comprehensive insight into needs, influencing factors and outcomes in the context of perceived safety and digital technologies in healthcare.MethodsWe employed a participatory, design ethnographic research approach with 16 participants in 10 use cases. The methods included in an iterative process were, think-aloud, guideline-based interviews, process mapping, storyboard creation, and photo documentation. A qualitative, primarily inductive data analysis and synthesis was performed.ResultsPerceived safety is influenced by various factors and unmet needs. Increased perceived safety can positively support the use of digital technologies, whereas low perceived safety can limit or even hinder its use.ConclusionThe needs of the different target groups should be considered throughout the entire process of digital technology development and healthcare provision to support their implementation. These findings support further research by providing specific aspects of emotional and psychological safety regarding target groups, settings, and ages and those with different levels of affinity for digital technologies.
Peptides Evaluated In Silico, In Vitro, and In Vivo as Therapeutic Tools for Obesity: A Systematic Review
Authors: Aguiar Ana Júlia Felipe Camelo , de Medeiros Wendjilla Fortunato , da Silva-Maia Juliana Kelly , Bezerra Ingrid Wilza Leal , Piuvezam Grasiela , Morais Ana Heloneida de Araújo 
Published: September 2024

Bioinformatics has emerged as a valuable tool for screening drugs and understanding their effects. This systematic review aimed to evaluate whether in silico studies using anti-obesity peptides targeting therapeutic pathways for obesity, when subsequently evaluated in vitro and in vivo, demonstrated effects consistent with those predicted in the computational analysis. The review was framed by the question: “What peptides or proteins have been used to treat obesity in in silico studies?” and structured according to the acronym PECo. The systematic review protocol was developed and registered in PROSPERO (CRD42022355540) in accordance with the PRISMA-P, and all stages of the review adhered to these guidelines. Studies were sourced from the following databases: PubMed, ScienceDirect, Scopus, Web of Science, Virtual Heath Library, and EMBASE. The search strategies resulted in 1015 articles, of which, based on the exclusion and inclusion criteria, 7 were included in this systematic review. The anti-obesity peptides identified originated from various sources including bovine alpha-lactalbumin from cocoa seed (Theobroma cacao L.), chia seed (Salvia hispanica L.), rice bran (Oryza sativa), sesame (Sesamum indicum L.), sea buckthorn seed flour (Hippophae rhamnoides), and adzuki beans (Vigna angularis). All articles underwent in vitro and in vivo reassessment and used molecular docking methodology in their in silico studies. Among the studies included in the review, 46.15% were classified as having an “uncertain risk of bias” in six of the thirteen criteria evaluated. The primary target investigated was pancreatic lipase (n = 5), with all peptides targeting this enzyme demonstrating inhibition, a finding supported both in vitro and in vivo. Additionally, other peptides were identified as PPARγ and PPARα agonists (n = 2). Notably, all peptides exhibited different mechanisms of action in lipid metabolism and adipogenesis. The findings of this systematic review underscore the effectiveness of computational simulation as a screening tool, providing crucial insights and guiding in vitro and in vivo investigations for the discovery of novel anti-obesity peptides.
Pengaruh edukasi melalui media leaflet tentang 3M plus terhadap pengetahuan pencegahan Demam Berdarah Dengue
Authors: Kaswulandari Latifatuh , Rachman Moh. Zainol , Yudiernawati Atti 
Published: September 2024

Latar Belakang: Demam Berdarah Dengue (DBD) merupakan penyakit yang disebabkan oleh virus dengue yang ditularkan melalui vector nyamuk. Data Kementerian Kesehatan (Kemenkes) tahun 2023 menunjukkan, di Negara Indonesia pada tahun 2022 terjadi kasus DBD sebanyak 143.266 dengan data kematian sebanyak 1.237.Metode: Menggunakan metode kuantitatif desain Pre-Experimental dengan pendekatan One Group Pretest-Posttest. Sampel pada penelitian ini santriwati Pondok Pesantren Sabilurrosyad Gasek Malang yang berjumlah 48. Teknik pengumpulan data menggunakan kuesioner untuk mengukur pengetahuan responden.Hasil: Data nilai p value yaitu 0,02 yang berarti kurang dari 0,05 sehingga H0 ditolak dan H1 diterima.Kesimpulan: Ada pengaruh edukasi melalui media leaflet tentang 3M Plus terhadap pengetahuan pencegahan Demam Berdarah Dengue di Pondok Pesantren Sabilurrosyad Gasek Malang.
UNA REVISIÓN SOBRE LOS ESTILOS DE CRIANZA 2020-2024, APLICANDO INTELIGENCIA ARTIFICIAL CON ATLAS.TI V.24
Authors: Rivas Rolly , Jaimes-Yábar Fredy , Huerta-Camones Pilar 
Published: September 2024

Los Estilos de Crianza (EC), se han investigado en su mayoría desde el enfoque cuantitativo; asimismo, el uso de la Inteligencia Artificial (IA) de ATLAS.ti, en el análisis de artículos, puede ser una herramienta importante para los investigadores. Introducción. El estudio de los EC sigue en evolución, por lo cual, un estudio de revisión puede darnos más información sobre este constructo. Objetivos. Como primer objetivo, conocer que metodología es más frecuente en las investigaciones sobre los EC. Como segundo objetivo, que conceptos son más considerados por los investigadores de los EC. Como tercer objetivo, que códigos emergentes son los más frecuentes en el análisis de los artículos seleccionados; finalmente como cuarto objetivo, que ventajas otorga el uso de la IA de ATLAS.ti, para el análisis de artículos. Métodos. Se ha optado por la revisión sistemática de diez artículos sobre EC, desde la base de datos Web of Science, publicados entre los años 2020 – 2024; empleando la IA de ATLAS.ti para el análisis de los artículos seleccionados. Resultados. La mayoría de las investigaciones sobre los EC, han sido abordados desde el enfoque cuantitativo. Los conceptos más utilizados por los investigadores son estilos de crianza, conducta, familia, hijos, entre otros. Los códigos emergentes más frecuentes son: estilos de crianza, inteligencia emocional, adolescentes y autoestima. La IA de ATLAS.ti, ayuda en gran medida, el análisis y síntesis de los artículos seleccionados. Conclusiones. Se precisan más investigaciones sobre los estilos de crianza, bajo el enfoque cualitativo. Los EC cumplen un rol influyente en el desarrollo integral de los hijos. El uso de la IA, de ATLAS.ti, puede presentar algunos errores como repetición, no discriminación entre los idiomas, errores de sintaxis y de semántica en los resúmenes, sin embargo, con la verificación necesaria, se convierte en una herramienta sumamente interesante.
New Criteria for Meromorphic Bazilević Functions Associated with Linear Operator
Authors: Al-khafaji Saba N. , Juma Abdul Rahman S. , Abdulhussain Mushtaq S. 
Published: September 2024

In this work, was proposed and characterized a new linear operator and having this linear operator establishing, we benefited from it to define class of meromorphic Bazilević functions in the punctured unit disk . What's more, we obtain some adequate conditions for functions having a place with this class.
Transformations and Persistence of Child Poverty in Portugal
Authors: Diogo Fernando , Trevisan Gabriela , Sarmento Manuel 
Published: September 2024

This paper presents the main data on child poverty in Portugal from Eurostat's EU-SILC, in comparison with the European Union and with selected European countries in the period of 2003 to 2020. These data are, first, contextualized by a discussion of the concept of child poverty, reflecting on its potentials and limitations from the framework of childhood and poverty. Secondly, it is Eurostat's own concept of poverty that is discussed, showing its potential and limitations on the data on child poverty. It is underlined that Eurostat statistics tend to underestimate the extent of child poverty in Europe. The data itself shows that child poverty is very relevant in Portuguese society (18.4% of children – average of 2003-2020). This especially affects certain types of families with children and is always higher than the general (at risk of) poverty rate. Portuguese results are not very different from the territories chosen for comparison, being even the least onerous in all of southern Europe. The analysis of the EU-SILC results ends with the demonstration that the social support provided by the state does not have a significant impact on the reduction of child poverty, in contrast to what happens in relation to the elderly, indicating that the social support goes, mainly, to retired people. This is especially relevant in the context of a country where there hasn’t been the replacement of generations for a long time (low synthetic fertility index).

Received: 18 March 2024 / Accepted: 2 July 2024 / Published: 05 September 2024
The Impact of Social Media Content on Cosmetic Choices Among Arab Girls
Authors: El Din Omer Emad , Bali Ahmed Omar 
Published: September 2024

This research, “The Impact of Social Media Content on Cosmetic among Arab Girls” provides an insightful analysis of how social media platforms like Facebook and Instagram are influencing cosmetic choices among young Arab women. Involving 661 participants, primarily aged 19-25, the research reveals a trend towards minimally invasive beauty methods, influenced by online beauty standards. Importantly, it examines the interaction between traditional Arab cultural values and the influence of modern social media on self-perception and beauty choices. The research suggests a complex relationship where Arab women balance traditional values with the allure of cosmetic enhancements, including surgery. These findings offer an in-depth understanding of the social, cultural, and psychological dimensions of beauty standards among Arab women, influenced by digital media.

Received: 30 April 2024 / Accepted: 31 August 2024 / Published: 05 September 2024