bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insight into Oxygen Transport in Proton Exchange Membrane Water Electrolyzers by In Situ X‐Ray Characterization
Authors: Li Ping'an , Zhou Zihan , Qiu Diankai , Peng Linfa 
Published: September 2024

AbstractThe proton exchange membrane water electrolyzer (PEMWE) is one of the most promising electrochemical energy conversion devices for hydrogen production, while still limited by performance bottlenecks at high current densities, due to the lack of mass transfer insights. To investigate the mechanisms of oxygen transport inside the PEMWE at high current density and its relation to electrolytic performance. Operational in situ x‐ray imaging is utilized to simultaneously characterize the bubble behavior and voltage response in a novel designed visual mini‐cell, and it is identified that oxygen evolution and transport in the PEMWE follow the process of bubble nucleation, growth, and detachment. Based on the results of mini‐cells with three porous transport layers (PTLs) up to 9 A cm−2 operation, it revealed that critical current densities exist for both carbon‐based and titanium‐based PTLs. Once exceeding the critical current density, the cell voltage can no longer be stabilized and the cell exhibits a significant oxygen overpotential. To illustrate this, the concept of interfacial separation zone (ISZ) is first proposed, which is an effective pathway for bubble growth and separation and the pattern of the ISZ exhibits specific regimes with the critical current density. Ultimately, a new approach for better understanding the mechanisms of oxygen transport is revealed.
Tunable Anomalous Hall Effect in a Kagomé Ferromagnetic Weyl Semimetal
Authors: Pate Samuel E. , Wang Bin , Zhang Yang , Shen Bing , Liu Enke , Martin Ivar , Jiang J. Samuel , Zhou Xiuquan , Chung Duck Young , Kanatzidis Mercouri G. , Welp Ulrich , Kwok Wai‐Kwong , Xiao Zhi‐Li 
Published: September 2024

AbstractEmerging from the intricate interplay of topology and magnetism, the giant anomalous Hall effect (AHE) is the most known topological property of the recently discovered kagomé ferromagnetic Weyl semimetal Co3Sn2S2 with the magnetic Co atoms arranged on a kagomé lattice. Here it is reported that the AHE in Co3Sn2S2 can be fine‐tuned by an applied magnetic field orientated within ≈2° of the kagomé plane, while beyond this regime, it stays unchanged. Particularly, it can vanish in magnetic fields parallel to the kagomé plane and even decrease in magnetic fields collinear with the spin direction. This tunable AHE can be attributed to local spin switching enabled by the geometrical frustration of the magnetic kagomé lattice, revealing that spins in a kagomé ferromagnet change their switching behavior as the magnetic field approaches the kagomé plane. These results also suggest a versatile way to tune the properties of a kagomé magnet.
Sn‐Doping‐Induced Biphasic Structure Advances Ductile Ag2S‐Based Thermoelectrics
Authors: Wu Hao , Shi Xiao‐Lei , Mao Yuanqing , Li Meng , Wu Ting , Wang De‐Zhuang , Yin Liang‐Cao , Zhu Ming , Liu Wei‐Di , Wang Lijun , Wang Yifeng , Duan Jingui , Liu Qingfeng , Chen Zhi‐Gang 
Published: September 2024

AbstractDue to its inherent ductility, Ag2S shows promise as a flexible thermoelectric material for harnessing waste heat from diverse sources. However, its thermoelectric performance remains subpar, and existing enhancement strategies often compromise its ductility. In this study, a novel Sn‐doping‐induced biphasic structuring approach is introduced to synergistically control electron and phonon transport. Specifically, Sn‐doping is incorporated into Ag2S0.7Se0.3 to form a biphasic composition comprising (Ag, Sn)2S0.7Se0.3 as the primary phase and Ag2S0.7Se0.3 as the secondary phase. This biphasic configuration achieves a competitive figure‐of‐merit ZT of 0.42 at 343 K while retaining exceptional ductility, exceeding 90%. The dominant (Ag, Sn)2S0.7Se0.3 phase bolsters the initially low carrier concentration, with interfacial boundaries between the phases effectively mitigating carrier scattering and promoting carrier mobility. Consequently, the optimized power factor reaches 5 µW cm−1 K−2 at 343 K. Additionally, the formation of the biphasic structure induces diverse micro/nano defects, suppressing lattice thermal conductivity to a commendable 0.18 W m−1 K−1, thereby achieving optimized thermoelectric performance. As a result, a four‐leg in‐plane flexible thermoelectric device is fabricated, exhibiting a maximum power density of ≈49 µW cm−2 under the temperature difference of 30 K, much higher than that of organic‐based flexible thermoelectric devices.
Dual drug co‐encapsulation of bevacizumab and pemetrexed clocked polymeric nanoparticles improves antiproliferative activity and apoptosis induction in liver cancer cells
Authors: Ganesan Subbulakshmi , Upadhye Vijay J. , Aulakh Damanjeet , Bishnoi Sunita , Chinnathambi Arunachalam , Alahmadi Tahani Awad , Abudoleh Suha Mujahed , Arulselvan Palanisamy , Thangavelu Indumathi 
Published: September 2024

AbstractNanoparticle (NP) enabled approaches have been employed for chemotherapeutic administration due to their capacity to regulate drug release and reduce side effects. Additionally, these methods can use several drugs concurrently and impede the proliferation of cancer cells that have developed resistance. Bevacizumab (BVZ) and pemetrexed (PEM) have demonstrated encouraging outcomes in the treatment and management of cancer. This work investigates the combined antiproliferative efficacy of BVZ and PEM co‐loaded PLGA‐PEG NPs (BVZ/PEM@PLGA‐PEG NPs) against HepG2 liver cancerous cells. The BVZ/PEM@PLGA‐PEG exhibited a sphere‐shaped and consistent nanosized distribution. In addition, we evaluated the potential mechanisms for inhibiting cell growth and inducing apoptosis using DAPI staining and cell cycle study. The beneficial combined antiproliferative activity and the apoptosis pathway were detected in the HepG2 cells exposed to BVZ/PEM@PLGA‐PEG NPs. Our study determined that the combinational drug treatment of BVZ/PEM@PLGA‐PEG NPs has a significant effect on promoting the effectiveness of liver cancer treatment.
“Dead Lithium” Formation and Mitigation Strategies in Anode‐Free Li‐Metal Batteries
Authors: Abdollahifar Mozaffar , Paolella Andrea 
Published: September 2024

AbstractThin lithium‐metal foil is a promising anode material for next‐generation batteries due to its high theoretical specific capacity and low negative potential. However, safety issues linked to dendrite growth, low‐capacity retention, and short cycle life pose significant challenges. Also, it has excess energy that must be minimized in order to reduce the battery costs. To limit excess lithium, practical lithium metal batteries need a negative‐to‐positive electrode ratio as close to 1 : 1 as possible, which can be achieved through limiting excess lithium or using an “anode‐free” metal battery design. However, both designs experience fast capacity fade due to the irreversible loss of active lithium in the cell, caused by the formation of the solid electrolyte interphase (SEI), dendrite formation and “dead lithium,” – refers to lithium that has lost its electronic connection to the anode electrode or current collector. The presence of dead lithium in batteries negatively affects their capacity and lifespan, while also raising internal resistance and generating heat. Additionally, dead lithium encourages the growth of lithium dendrites, which poses significant safety hazards. Within this fundamental review, we thoroughly address the phenomenon of dead lithium formation, assessing its origins, implications on battery performance, and possible strategies for mitigation. The transition towards environmentally friendly and high‐performance metal batteries could be accelerated by effectively tackling the challenge posed by dead lithium.
Recent Advances in Salt‐Template Assisted Synthesis of 3D Porous Carbon Materials for Electrochemical Energy Storage
Authors: Jiang Cao , Liu Huawei , Ye Jingzhe , Wang Ning , Tang Ying , He Chunnian , Zhang Haichang , Chen Biao 
Published: September 2024

AbstractThe structure, morphology, and composition of electrode materials play a crucial role in determining the electrochemical performance of energy storage devices. Among various materials, three‐dimensional (3D) porous carbon stands out for its potential to enhance electrochemical energy storage due to its cost‐effectiveness, excellent ion and electron conductivity, abundant active sites, and customizable pore structure. The salt‐template method offers an environmentally friendly, fast, and cost‐efficient approach to synthesizing 3D porous carbon, with the added advantage of adjustable pore architecture and composition. This review provides a comprehensive overview of recent advancements in preparing 3D porous carbon and its composites using the salt‐template method, emphasizing their applications in batteries and supercapacitors. It also critically examines the existing challenges and explores potential future directions for further development in this field.
Amyloid Fibril Formation on Neuronal Cells in the Coexistence of Aβ40 and Aβ42
Authors: Kawaguchi Mayu , Kawano Kenichi , Taniguchi Aoi , Tanaka Atsushi , Matsuzaki Katsumi 
Published: September 2024

AbstractThe abnormal aggregation and subsequent deposition of amyloid β‐protein (Aβ) in the brain are considered central to the pathogenesis of Alzheimer's disease. The two major species of Aβ are Aβ40 and Aβ42, present at an approximate ratio of 9 : 1. Accumulating evidence suggests that neuronal membranes are an important platform of amyloidogenesis by Aβ. However, information on the aggregational behaviors of coexistent Aβ40 and Aβ42 on membranes is lacking. In this study, the aggregation and resultant cytotoxicity of coexistent Aβ40 and Aβ42 at a physiologically relevant ratio were investigated by fluorescence techniques. We found that the degree of coexistence of both Aβs in aggregates increased as the assembly proceeded, and reached a maximum in fibrils. Cross‐seeding experiments supported the hypothesis that Aβ40 and Aβ42 interact with each other in the fibrillar states when formed on membranes. However, the cytotoxicity of the mixed fibrils was weaker than that of Aβ42 fibrils, suggesting the possibility that Aβ40 attenuates the toxicity of Aβ42 by forming mixed fibrils. In contrast, the degree of coexistence was significantly lower in aqueous phase aggregation, highlighting different aggregation mechanisms between in membranes and in the aqueous phase.
Early outcomes with a fully retrievable SinoCrown transcatheter heart valve in patients with severe aortic stenosis
Authors: Li Yuehuan , Xiong Zhongyu , Lei Ruobing , Wang Jiangang , Zhang Haibo 
Published: September 2024

AbstractBackgroundThis study summarizes and analyzes data from patients suffering from symptomatic aortic stenosis who successfully underwent transcatheter aortic valve implantation (TAVI) using a novel, completely retrievable transcatheter heart valve.MethodsWe included patients who underwent a TAVI procedure with SinoCrown valves at our center between December 2021 and September 2022. We collected 1‐year follow‐up data on survival, complications, echocardiographic results, New York Heart Association functional class in heart failure, and patient‐reported health‐related quality of life outcomes.ResultsEight successive patients (73.3 ± 4.3 years) were included in the study, with a median Society of Thoracic Surgery risk score of 4.26%. The procedure had a 100% success rate. Median postoperative discharge time was 7 days, with no 30‐day hospital readmissions. Postoperative aortic valve hemodynamics improved, indicated by decreased transvalvular flow velocity compared with preoperative values (1.9 ± 0.2 vs. 4.9 ± 0.2 m/s, p < 0.0001). The median and maximum follow‐up times were 8 and 12 months, respectively. During the follow‐up period, there were no serious complications such as death, stroke, valve embolization, or high‐grade atrioventricular block.ConclusionsThe results from eight initial TAVI cases performed with the SinoCrown valve demonstrated promising safety and efficacy.
Impact of residual mitral regurgitation after transcatheter edge‐to‐edge repair in atrial functional mitral regurgitation: Results from MITRA‐PRO registry
Authors: Rottländer Dennis , Hausleiter Jörg , Schmitz Thomas , Bufe Alexander , Seyfarth Melchior , von Bardeleben Ralph Stephan , Beucher Harald , Ouarrak Taoufik , Schneider Steffen , Boekstegers Peter ,   MITRA‐PRO Investigators
Published: September 2024

AbstractBackgroundTranscatheter edge‐to‐edge repair (TEER) has emerged to address symptomatic atrial functional mitral regurgitation (aFMR) in patients who are at high operative risk.AimsNo clinical data is available on the impact of residual mitral regurgitation (MR) following TEER in aFMR compared to ventricular functional MR (vFMR).MethodsIn the MITRA‐PRO registry, 846 patients with FMR and MitraScore assessment for residual MR quantification were included (722 patients with vFMR and 124 patients with aFMR).ResultsCompared to vFMR similar procedural results in regard of residual MR following TEER were found in aFMR patients (MitraScore post TEER 2.5 ± 1.8 vs. 2.7 ± 1.9), while the amount of implanted TEER devices was increased in vFMR. 1‐year survival was better in aFMR compared to vFMR regardless of relevant residual MR (MitraScore ≥ 4), while 1‐year rehospitalization was comparable for both MR entities. Patients with aFMR and mild residual MR had a lower mortality rate (6.6% vs. 10.3%) and rehospitalization rate (29.1% vs. 46.2%) 1 year after mitral TEER. However, in contrast to vFMR a MitraScore ≥4 was no independent predictor of mortality in aFMR indicating a better tolerance toward residual MR.ConclusionsResidual MR is an independent predictor of 1‐year mortality in vFMR patients, whereas in aFMR patients, a MitraScore of ≥4 is associated with higher mortality but is not an independent predictor in multivariate analysis. Therefore, minimizing MR through mitral TEER is crucial for survival in vFMR patients, while aFMR patients tolerate significant residual MR better 1 year after the procedure.
A 27‐year scoping review of practice and research in online counselor education
Authors: Manis Amie A. , Banks‐Johnson Angela , Hays Danica G. 
Published: September 2024

AbstractA scoping review of the online counselor education scholarship from 1997 to 2023 in 27 national and regional peer‐reviewed counseling journals yielded a sample of 110 articles. Findings of the scoping review detailed the topics addressed, methodological features, key findings, and recommendations for practice and research.
Cord blood granulocyte levels are associated with severe bronchiolitis in the first year of life
Authors: Martins Costa Gomes Gabriela , Da Silva Sena Carla Rebeca , Murphy Vanessa E , Hansbro Philip M , Starkey Malcolm R , Gibson Peter G , Mattes Joerg , Collison Adam M 
Published: September 2024

AbstractObjectivesBronchiolitis is a leading cause of infant hospitalisation in the first year of life, and it preferentially affects infants born to mothers with asthma. Here, we evaluate cord blood granulocytes in infants born to mothers with asthma participating in the Breathing for Life Trial (BLT), to investigate early life determinants of bronchiolitis hospitalisation within the first year of life.MethodsCord blood from 89 participants was collected into EDTA tubes and processed within 6 h of birth. Cells were stained in whole cord blood for eosinophils (CD45+, CD193+, CD16−), and neutrophils (CD45+, CD193−, CD16+). Medical records were reviewed for bronchiolitis hospitalisation in the first 12 months of life. Statistical analyses were conducted using Stata IC16.1.ResultsLogistic regression adjusted for caesarean section, gestational age, maternal smoking during pregnancy, foetal heart deceleration during labour, and season of birth revealed an association between cord blood eosinophil levels and bronchiolitis hospitalisation in the first 12 months of life with an Area Under the Curve (AUC) of the Receiver Operating Characteristic (ROC) curve of 0.943 (aOR = 1.35, P = 0.011). Neutrophils were associated with the risk of bronchiolitis hospitalisation in a univariable logistic regression (OR = 0.93, P = 0.029); however, there was no statistical significance in the adjusted model.ConclusionsHigher eosinophil numbers in cord blood were associated with bronchiolitis hospitalisation in the first 12 months in a cohort of infants born to asthmatic mothers. This suggests that susceptibility to bronchiolitis in later life is influenced by the immune cell profile prior to viral infection.
Cleaner and sustainable circular economy approaches for bio‐based product recovery from industrial effluents in a biorefinery
Authors: Aryanfar Yashar , Castellanos Humberto Garcia , Hammoodi Karrar A. , Farifteh Mohadeseh (Maya) , Keçebaş Ali , Ghasemlou Shaban Mousavi , Mammadova Afsana , Yengejeh Ehsan Alipour , Neghabi Zahra Houshmand 
Published: September 2024

AbstractThis article investigates the integration of circular economy methodologies and biorefinery concepts for the sustainable recovery of bio‐based products from industrial effluents, addressing the critical need for resource efficiency and environmental sustainability in the face of climate change and resource depletion. Emphasizing the valorization of industrial by‐products, the study explores innovative, eco‐friendly recovery processes within a biorefinery framework to transform waste into valuable resources such as biofuels, biochemicals, and biomaterials. Through a systematic search in various bibliographic databases and a comprehensive literature review, the study critically analyzes existing studies, identifies research gaps, and offers new perspectives on the integration of biorefinery and circular economy principles. The findings reveal that strategic integration of biorefinery processes and circular economy principles can significantly reduce environmental footprints and foster sustainable industrial practices. Key challenges such as feedstock variability, technological barriers, and economic scalability are identified, along with recommendations for overcoming these obstacles through interdisciplinary collaboration, technological innovation, and supportive policy interventions. The main contribution of this research lies in its comprehensive approach, integrating cutting‐edge technologies and circular economy principles to offer viable strategies for sustainable bio‐based product recovery, thus significantly advancing the field of industrial sustainability. The article contributes to the advancement of sustainable technologies, policies, and strategies, advocating for a transition towards a more circular, resource‐efficient industrial sector. Continued innovation and research are emphasized to optimize recovery processes and explore new applications, supporting a sustainable and thriving future for our planet.
Nicotine as a female reproductive toxicant—A review
Authors: Bhardwaj Jitender Kumar , Siwach Anshu , Sachdeva Som Nath 
Published: September 2024

AbstractThe preceding decades have seen an extensive emergence of the harmful effects of tobacco smoke on systemic health. Among the various compounds of tobacco, nicotine is one of the principal, potentially hazardous, and toxic components which is an oxidant agent that can affect both men's and women's fertility. Nicotine exerts its effect by modulating the expression of transmembrane ligand‐gated ion channels called nicotinic acetylcholine receptors. The activities of female reproduction might be disrupted by exposure to nicotine at various sites, such as the ovary or reproductive tract. It's been demonstrated that nicotine might cause oxidative stress, apoptosis, hormonal imbalance, abnormalities in chromosomal segregation, impact oocyte development, and disruption in ovarian morphology and functions. This review paper summarizes the findings and provides an updated overview of the evidence on the harmful effects of nicotine use on women's reproductive health and the resulting detrimental impacts on the body. Additionally, it provides the detailed possible mechanisms involved in impairing reproductive processes like folliculogenesis, oocyte maturation, steroidogenesis, and pregnancy in different animal species.
Quantitative Characterization of Zebrafish Caudal Fin Regeneration Based on Mueller Matrix OCT In Vivo
Authors: Wang Zaifan , Li Ke , Chen Hui , Li Zhifang , Li Wangbiao , Lin Hui , Zheng Liqin , Zhang Xiaoman , Wu Shulian 
Published: September 2024

ABSTRACTZebrafish serves as a valuable model for studying tissue regeneration due to their comprehensive regenerative abilities, particularly in bone tissue. In this study, a Mueller matrix optical coherence tomography (OCT) system was applied to monitor the regenerative processes of zebrafish caudal fins in vivo. The analysis focused on evaluating the thickness of the caudal fin tip and the distribution of internal bone tissue during the regenerative process. Subsequently, the effect of ectoine solution on the regeneration process was observed and discussed. Our findings revealed that the caudal fin blastema did not exhibit phase‐induced polarization characteristics in the Mueller matrix OCT images. Statistical analyses indicated that the caudal fins did not fully regenerate to their original state within 21 days. Furthermore, the results suggested that ectoine solution could enhance tissue regeneration. This approach provides a method for quantifying zebrafish caudal fin regeneration and advances observation techniques for biomedical and clinical applications.
Production and Characterization of Electrospun Chitosan, Nanochitosan and Hyaluronic Acid Membranes for Skin Wound Healing
Authors: Ponte Edimar Dal , de Almeida Ignatowicz Alexia , Volpato Gabriel Raio , Taffarel João Vitor , Takahashi Priscila Ayumi , Luiz Rafael Messias , Silva Felipe Eduardo Bueno , Fraga Gabriel Nardi , Dragunski Douglas Cardoso , Zarpelon‐Schutz Ana Carla , Alves Helton José , Bernardi‐Wenzel Juliana 
Published: September 2024

ABSTRACTThe development of new wound dressings made from biomaterials, which offer a better cost–benefit ratio and accelerate the healing process, is increasing nowadays. Various biopolymers can be electrospun to form functional membranes for wound healing. Therefore, in this study, chitosan and nanochitosan membranes with or without hyaluronic acid were prepared using the electrospinning technique, characterized and evaluated in the healing of skin wounds in rats. Chitosan and nanochitosan solutions, with or without hyaluronic acid, were prepared at concentrations of 1%–4% using PEO (polyethylene oxide) and subjected to the electrospinning process to obtain membranes characterized by scanning electron microscopy (SEM), mechanical tests, and antimicrobial activity. The healing effect of the membranes was evaluated by monitoring the area of the lesions, contraction of the wounds, histologic analysis, and induction of pro‐inflammatory cytokine (IL‐1 α and TNF‐α) production in rats. The nanochitosan and nanochitosan membranes with hyaluronic acid achieved greater fiber diameter and uniformity, resistance, elasticity, and thermal stability, in addition to good adhesion to the wound bed and permeation capacity. Despite not presenting antimicrobial activity in vitro, they contributed to the production of pro‐inflammatory interleukins in the animals tested, provided physical protection, reduced the wound area more markedly until the seventh day of the evaluation, with an acceleration of the healing process and especially when functionalized with hyaluronic acid. These results indicate that the membranes may be promising for accelerating the healing process of chronic wounds in humans.