bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Creatine Supplementation on the Performance, Physiological Response, and Body Composition Among Swimmers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Huang Dongxiang , Wang Xiaobing , Gonjo Tomohiro , Takagi Hideki , Huang Bo , Huang Wenrui , Shan Qi , Chow Daniel Hung-Kay 
Published: October 2024

Abstract
Background
Although recent studies have increasingly focused on examining the potential benefits of creatine supplementation to improve performance in swimming events, the impact of creatine supplementation on swimming performance remains a topic of debate and controversy. A comprehensive meta-analytical review was undertaken to evaluate the effects of creatine supplementation on the performance, physiological response, and body composition among swimmers.

Methods
The research methodology adhered strictly to the guidelines outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A comprehensive search was conducted across six databases (Cochrane Library, Web of Science, Scopus, Embase, PubMed, and SPORTDiscus) until March 23, 2024. Eligible studies that investigated the impact of creatine supplementation on swimming time, physiological parameters, and body composition in swimmers were included. For the meta-analysis, a random-effects model was employed to determine the collective effect and assess variations across distinct subgroups defined by swimming time, physiological metrics, and body composition. Meta-regression analysis was conducted on datasets comprising ten or more studies. Standardized mean differences (SMD) along with their corresponding 95% confidence intervals (CI) were calculated. To evaluate the methodological rigor of the included studies, the Physiotherapy Evidence Database (PEDro) scale was utilized.

Results
The systematic review included seventeen studies with a total of 361 subjects. No significant differences were observed in the overall effect during single sprint swimming (SMD: -0.05, 95% CI: -0.26, 0.15; p = 0.61), repeated interval swimming (SMD: -0.11; 95% CI: -0.46, 0.25; p = 0.56), physiological response (SMD: 0.04, 95% CI: -0.16, 0.23; p = 0.71), and body composition (SMD: 0.18; 95% CI: -0.05, 0.41; p = 0.12) between creatine and placebo groups.

Conclusions
Creatine supplementation exhibited ineffectiveness in enhancing the performance, physiological response, and body composition among swimmers.
The development and testing of a single-arm feasibility and acceptability study of a whole foods diet intervention for adults with prediabetes and their offspring
Authors: Sneed Nadia M. , Kelley Raegan , Turner Haley , Piano Mariann R. , Dagostino Chloe , Sellers Ashley , Bonnet Kemberlee , Schlundt David , Adams Laura E. , Heerman William J. 
Published: October 2024

Abstract
Background
Diet is considered a first-line treatment option for prediabetes, a condition that affects 96 million United States (U.S.) adults. Diet patterns that prioritize whole foods (e.g., Mediterranean) are currently recommended to treat prediabetes. However, no studies have tested whether a U.S.-style diet pattern that prioritizes whole foods can be used to treat prediabetes. The purpose of this study was to assess the feasibility and acceptability of a whole foods diet for adults with prediabetes and their offspring prior to conducting a larger clinical trial.

Methods
A 2-week single-arm pre-post experimental controlled-feeding intervention of a 2020–2025 Dietary Guidelines for Americans adapted whole foods diet (e.g., primarily focused on foods that have undergone limited processing or refinement) was conducted in adults (25–59 years) with prediabetes and their biological offspring (6–17 years). Families received 2 weeks of menus and grocery delivery and weekly counseling by a registered dietitian. Families were invited to attend an optional focus group session. Feasibility was based on having a ≥ 50% family completion rate with ≥ 80% completion of study outcomes. Measures included adult–child anthropometrics (weight [kg], body mass index [BMI] including BMI% and Z-scores for offspring, waist circumference [cm]) and child diet quality estimated using the 2015 Healthy Eating Index (HEI) from a single random food record. Wilcoxon signed rank was used to compare differences between baseline and 2-week anthropometrics measures and offspring total HEI scores. Qualitative data were analyzed using thematic analysis to understand factors attributed to diet adherence and acceptability.

Results
Eight families enrolled (n = 8 adults, n = 12 offspring), with 7 families completing the study (12% attrition) and completing 100% of study outcome measures. Adults experienced a median weight loss of − 1.0 kg from baseline to 2 weeks (79.5 kg to 78.5 kg). Offspring had a 24-point increase in total 2015 HEI scores (median difference 50 to 74). Focus group participants (n = 4 adults) reported being satisfied with the program and expressed a willingness to continue the diet despite identified barriers.

Conclusions
A whole foods diet that provides dietary support was found to be feasible and acceptable for families at risk for T2D. Future studies are needed to test the effects of the diet on prediabetes outcomes, diet quality, and diet adherence in adults and families.

Trial registration
NCT05483972 at ClinicalTrials.gov. Registered July 25, 2022. https://clinicaltrials.gov/study/NCT05483972?cond=prediabetes&term=whole%20foods%20&rank=1
Empagliflozin as a novel therapy for cirrhotic refractory ascites: a randomized controlled study
Authors: Bakosh Mohamed Fathy , Ghazy Ramy Mohamed , Ellakany Walid Ismail , Kamal Ahmed 
Published: October 2024

Abstract
Background
Cirrhotic refractory ascites (RA) patients have few alternatives for treatment. Empagliflozin is now known to have natriuretic and neurohormonal modulatory effects. This research investigated the safety and efficacy of empagliflozin in the management of RA when added to the standard of care (SoC) compared to SoC alone.

Methods
Patients were randomized to receive either a fixed dose of 10 mg of empagliflozin plus standard of care (SoC) or SoC alone. Patients were followed up for 3 months. The primary endpoint was achieving no need for large-volume paracentesis (LVP).

Results
Forty-two patients were randomized equally, and intention-to-treat was performed. There was a statistically significant decrease in the need for LVP in the empagliflozin group compared to the SoC group (100% in the SoC vs. 42.9% in the empagliflozin group, p < 0.001). By the end of the study, the total resolution of ascites was reported in approximately 24% of patients. Muscle cramps and newly developed hyponatremia were more common in the empagliflozin group, but they were mild. Acute kidney injury was more common in the SoC group.

Conclusions
Empagliflozin may be an effective option for use as an add-on therapy in the management of RA, with an accepted safety profile.

Trial registration
The trial was registered at www.clinicaltrials.gov under the identifier NCT05430243. The registration was submitted on 18/06/2022. It is available at https://clinicaltrials.gov/study/NCT05430243.

Graphical Abstract
Characterization of cancer-associated adipocytes by Raman spectroscopy and trajectory inference
Authors: Goffin Nicolas , Buache Emilie , Lalun Nathalie , Fernandes Marion , Miguel Ines , Muller Catherine , Vaysse Charlotte , Blanc Landry , Gobinet Cyril , Piot Olivier 
Published: October 2024

AbstractCancer-associated adipocytes (CAAs) have emerged as pivotal players in various cancers, particularly in such as breast cancer, significantly influencing their progression and therapy resistance. Understanding the adipocytes/cancer cells crosstalk is crucial for effective treatment strategies. Raman spectroscopy, a label-free optical technique, offers potential for characterizing biological samples by providing chemical-specific information. In this study, we used Raman spectroscopy and Trajectory Inference methods, specifically the Partition-based graph abstraction algorithm, to investigate the interactions between 3T3-L1 differentiated adipocytes and MDA-MB-231 breast cancer cells in a 2D co-culture model. We demonstrate the existence of subpopulations of adipocytes and the molecular changes associated with CAAs phenotype. This work contributes to understanding the role of CAAs in breast cancer progression and may guide the development of targeted therapies disrupting this interaction.
Characterization of a fluvial deltaic salt-influenced system for CO2 storage using seismic poststack inversion and self-organizing maps in the upper Miocene, Onshore Louisiana
Authors: Jacobsen Rae T. , Knapp James H. , Knapp Camelia C. 
Published: October 2024

Basins that have historically been explored for hydrocarbons are now seen through a new perspective for carbon capture and storage. Legacy hydrocarbon reservoirs may now have the potential to become carbon storage targets. The Miocene Sandstone in southeastern Louisiana is a stratigraphic interval that contains favorable zones for carbon storage, and seismic interpretation is a critical tool for characterizing these sands and estimating the amount of possible carbon storage. New workflows leveraging machine learning and seismic inversion can be applied to legacy fields to generate a new estimate for pore space and carbon storage capacity. The study area contains a 3D seismic survey covering 310 mi2 (803 km2) and 17 wells in the southeastern Louisiana Gulf Coast. The area is structurally complex with salt domes and numerous faults. Shelf-edge deltas are the primary sediment input for the target reservoirs, and these fluvial-deltaic sediments provide high porosity and permeable sands. The workflow leverages self-organized maps (SOMs) to identify zones of interest laterally and vertically for carbon storage. SOM can be computed quickly for screening and provides an uplift in resolution for interpretation compared with single attributes. A model-based acoustic impedance inversion produces porosity information and improved resolution that can be used in conjunction with SOM outputs. The acoustic impedance results strongly correlate to porosity within the target sands, and the SOM and porosity maps delineate specific sand lobes for potential storage. Wellbore data within the sand lobe align with SOM and inversion results and show rock quality with 26% average porosity and 90 ft gross thickness. The research highlights a project sized target within the middle Miocene containing 16, 24, and 52 megatons (P10, P50, P90) of estimated CO2 storage. Using SOM and inversion maps together is an effective way for investigating an area for carbon storage targets.
Cardiometabolic Risk Assessment in Transgender Individuals—Differential Effect of Sex Hormones and Sex Chromosomes
Authors: Lei Yu , Wiik Anna , Connelly Margery A , Lindberg Linnea , Andersson Daniel P , Arver Stefan , Gustafsson Thomas , Tietge Uwe J F 
Published: October 2024

Abstract

Context
While transgender individuals represent a substantial group seeking medical care, the differential effect of sex on cardiometabolic risk metrics is incompletely understood.

Objective
The present study aimed to characterize the effect of sex hormones and chromosomes on a contemporary panel of cardiometabolic risk biomarkers and functional cardiovascular measurements.

Methods
A total of 17 transgender men and 17 transgender women were studied at baseline (T0), 4 weeks (hormonal castration, T1), and 11 months following gender-affirming hormone treatment (T12). We analyzed carotid intima-media thickness and arterial stiffness, lipoproteins, and other metabolites comprehensively by nuclear magnetic resonance spectroscopy and high-density lipoprotein–mediated cholesterol efflux capacity (CEC) from macrophages. T0 to T12 comparisons informed the effect of sex hormones, comparisons of genetic XX and XY individuals at T1 the effect of sex chromosomes.

Results
Vascular function was comparable at T12 and T0; systolic blood pressure increased in transgender men (P = .002). Transgender men developed a proatherogenic lipoprotein profile; estrogen treatment in transgender women tended to result in improvements. Several metabolites indicating increased diabetes risk including plasma glucose were changed in transgender men (P = .025), with opposite changes in transgender women (P = .002). Interestingly, at T1 apparent diabetes risk was lower in XX compared with XY individuals (P = .002). CEC decreased in transgender women (P &lt; .01), while remaining unchanged in transgender men. However, in both groups the strong positive association of apolipoprotein A-1 with cholesterol efflux observed at T0 was lost at T12.

Conclusion
The results are consistent with increased cardiometabolic risk in transgender men, while transgender women show beneficial changes early during gender-affirming hormone therapy. Sex chromosomes have fewer intrinsic effects. XY individuals and transgender men display an increased apparent diabetes risk. Further research on cardiometabolic risk is needed for transgender individuals.
The Endocrine Feedback Loop Podcast: Past, Present, and Future
Authors: Hendrickson Chase D 
Published: October 2024

Abstract
In June 2024, the Endocrine Feedback Loop podcast recorded its fiftieth episode at the annual meeting of the Endocrine Society. Launched in May 2020, the podcast serves as a way for listeners to hear a critical analysis of recent and impactful research studies published in clinical journals of the Endocrine Society. The podcast follows methods proven effective in traditional journal clubs and adapts them to reach a wide audience with different levels of expertise in endocrinology. This Perspective outlines the history of the podcast, the process of producing a monthly episode, and the topics covered, as well as an assessment of the experience of producing the podcast and future plans for the Endocrine Feedback Loop.
Lack of Association of Chronological Age and Antithrombotic Agents With Acute Intracranial Hemorrhage in the Group of Older Adults With Traumatic Brain Injury
Authors: Kambara Mizuki , Ikawa Fusao , Hidaka Toshikazu , Yamamori Yuji , Yamamoto Yoshiaki , Michihata Nobuaki , Uchimura Masahiro , Yoshikane Tsutomu , Akiyama Yasuhiko , Horie Nobutaka , Hayashi Kentaro 
Published: October 2024

BACKGROUND AND OBJECTIVES:
Some reports suggest that older patients with traumatic brain injury (TBI) are more likely to experience acute intracranial hemorrhage, resulting in poor outcomes. However, the association between precise chronological age and use of antithrombotic agents with acute intracranial hemorrhage in these patients remains unknown. The aim of this study was to determine factors associated with acute intracranial hemorrhage and poor outcomes in patients with TBI, including chronological age and use of antithrombotic agents.

METHODS:
Patients hospitalized for TBI between January 2006 and December 2021 were included. Patients were categorized by age groups of <65 years, 65 to 74 years, 75 to 84 years, and ≥85 years. Associations between each age group and acute intracranial hemorrhage, a poor outcome at discharge, and in-hospital mortality were evaluated.

RESULTS:
The cohort included 1086 patients, with 713 (65.7%) in the ≥65 age group. Although chronological age was associated with acute intracranial hemorrhage in patients aged <65 years (odds ratio [OR] 1.02; 95% CI 1.01-1.03), it was not associated with patients aged ≥65 years. None of the antithrombotic agents investigated were associated with acute intracranial hemorrhage in the group aged ≥65 years. Although chronological age was associated with a poor outcome in patients aged <65 years (OR 1.03; 95% CI 1.01-1.07), it was not associated in those aged ≥65 years. The ≥85 year age group (OR 2.30; 95% CI 1.18-4.51) compared with <65 years were significantly associated with a poor outcome. None of the antithrombotic agents investigated were associated with a poor outcome in the group aged ≥65 years.

CONCLUSION:
Our findings confirmed the lack of an association of chronological age and antithrombotic agents with acute intracranial hemorrhage in the group of older adults with TBI. Our findings suggest that antithrombotic agents may be safely used, even in older adults.
Laparoscopic-Assisted, Percutaneous Cryoablation: A Novel Technique for the Treatment of Abdominal Wall Soft Tissue Tumors
Authors: Ricker Ansley Beth , Stone Taylor J. , Jagosky Megan H. , Anderson Colin J. , Squires Malcolm H. 
Published: October 2024

Abstract
Introduction
Percutaneous cryoablation is a first-line therapeutic option for primary neoplasms and metastatic lesions of the musculoskeletal system. Treatment of abdominal wall tumors is challenging as surgical resection can be highly morbid and necessitate complex reconstructive surgery; the efficacy of cryoablation for abdominal wall tumors may be limited by inadequate posterior margins owing to the proximity of intra-abdominal organs. With laparoscopy and insufflation, peritoneal structures can be safely mobilized away from the abdominal wall, allowing for adequate deep margin freeze and visualization of the ice ball. We present two patients with abdominal wall soft tissue tumors treated with a novel approach of laparoscopic-assisted, percutaneous ultrasound-guided cryoablation.

Patients and Methods
Patient 1 is a 65-year-old female with metastatic extraskeletal myxoid chondrosarcoma, stable on systemic therapy, who presented with a new soft tissue metastasis to the abdominal wall. Resection would have necessitated a highly morbid complex abdominal wall reconstruction with mesh. Patient 2 is a 35-year-old female with a large abdominal wall desmoid tumor, diagnosed after miscarriage. Resection was relatively contraindicated owing to the morbidity of a complex abdominal wall reconstruction and concerns regarding potential future pregnancies after surgery.

Results
Both patients underwent procedures in the outpatient setting after discussion at multidisciplinary sarcoma tumor board. Laparoscopic enterolysis was performed to mobilize the bowel away from the abdominal wall, to allow direct visualization of the peritoneal aspect of the tumor, and to confirm adequacy of the posterior margin freeze of the lesion. Laparoscopic transversus abdominus preperitoneal (TAPP) blocks with local anesthetic were performed for postoperative pain control. Interventional radiology performed an ultrasound-guided cryoablation consisting of two freeze and thaw cycles. Both patients recovered well without complications and were without radiographic evidence of persistent or recurrent disease at 12 and 18 months postoperatively, respectively.

Conclusion
We report a novel approach of laparoscopic-assisted cryoablation for the treatment of abdominal wall soft tissue tumors. This allowed for successful minimally invasive local control of these large tumors that would have otherwise required highly morbid resections with complex abdominal wall reconstruction and mesh repair.
On the Value of Risk-Averse Multistage Stochastic Programming in Capacity Planning
Authors: Yu Xian , Shen Siqian 
Published: October 2024

We consider a risk-averse stochastic capacity planning problem under uncertain demand in each period. Using a scenario tree representation of the uncertainty, we formulate a multistage stochastic integer program to adjust the capacity expansion plan dynamically as more information on the uncertainty is revealed. Specifically, in each stage, a decision maker optimizes capacity acquisition and resource allocation to minimize certain risk measures of maintenance and operational cost. We compare it with a two-stage approach that determines the capacity acquisition for all the periods up front. Using expected conditional risk measures, we derive a tight lower bound and an upper bound for the gaps between the optimal objective values of risk-averse multistage models and their two-stage counterparts. Based on these derived bounds, we present general guidelines on when to solve risk-averse two-stage or multistage models. Furthermore, we propose approximation algorithms to solve the two models more efficiently, which are asymptotically optimal under an expanding market assumption. We conduct numerical studies using randomly generated and real-world instances with diverse sizes, to demonstrate the tightness of the analytical bounds and efficacy of the approximation algorithms. We find that the gaps between risk-averse multistage and two-stage models increase as the variability of the uncertain parameters increases and decrease as the decision maker becomes more risk averse. Moreover, a stagewise-dependent scenario tree attains much higher gaps than a stagewise-independent counterpart, whereas the latter produces tighter analytical bounds. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms–Discrete. Funding: This work of Dr. X. Yu was partially supported by the U.S. National Science Foundation Division of Information and Intelligent Systems [Grant 2331782]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.0396 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0396 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Luz, câmera, quilombo: a projeção da imagem antirracista em sala de aula.
Authors: Eiras Rafael Garcia Madalen , Lemos Anna Paula Soares 
Published: October 2024

Este artigo reflete sobre a projeção cinematográfica em sala de aula através de uma proposta antirracista e decolonial. Partindo da vivência de um dos autores com a sua turma do ensino fundamental público do Rio de Janeiro (SME/RJ), ao exibir o filme Quilombo (1984) do diretor Cacá Diegues Uma análise que parte da hipótese de que o uso das práticas cinematográficas no ensino público pode ativar uma percepção plural da criança, em que todas as instâncias da cultura podem ser vistas como pedagógicas. Propondo, desta forma, diferentes perspectivas teóricas na busca por outros olhares que relacionem o cinema com a escola. Assim, o trajeto metodológico proposto entende que a análise e a prática cinematográfica sempre vão andar juntas, pois articulam diversas potencialidades estéticas, como som, diálogo, enquadramento, que precisam ser agenciados pelos próprios alunos.
A EJA pelo olhar de estudantes idosos: as motivações para estudar nessa fase da vida
Authors: Coura Isamara Grazielle Martins , Eiterer Carmem Lúcia , Soares Leôncio José Gomes 
Published: October 2024

O artigo apresenta a expectativas dos idosos a respeito da Educação de Jovens e Adultos, destacando as diferenças percebidas por eles quanto às metodologias e às posturas dos educadores comparados aos de outras épocas de suas vidas. Trata-se de uma análise a partir de dados de uma pesquisa de mestrado. A investigação teve caráter qualitativo e contou com a entrevista semiestruturada e análise documental para a produção de informações. Foram entrevistados sete idosos, sendo quatro mulheres e três homens, com idades entre 60 e 81 anos. Os resultados demonstram que na EJA, na medida em que suas expectativas vão se realizando, vão ampliando seus olhares, modificando suas visões acerca da educação e que a afetividade presente na relação entre professores e estudantes facilita a permanência na escola e o processo de aprendizagem. Os achados ainda contribuem para se pensar sobre a formação do educador da EJA.