bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upadacitinib in Patients With Difficult-to-Treat Crohn’s Disease
Authors: Bezzio Cristina , Franchellucci Gianluca , Savarino Edoardo V , Mastronardi Mauro , Caprioli Flavio Andrea , Bodini Giorgia , Variola Angela , Scaldaferri Franco , Furfaro Federica , Calabrese Emma , Principi Maria Beatrice , Biscaglia Giuseppe , Marzo Manuela , Michielan Andrea , Cavalli Carolina , Aratari Annalisa , Campigotto Michele , Ceccarelli Linda , Cappello Maria , Saibeni Simone , Balestrieri Paola , Soriano Alessandra , Casini Valentina , Bertani Lorenzo , Barberio Brigida , Conforti Francesco Simone , Danese Silvio , Armuzzi Alessandro 
Published: October 2024

Lay Summary
Upadacitinib has recently been approved for treating Crohn’s disease (CD). Here, we report on the effectiveness and safety of upadacitinib in a cohort of patients with difficult-to-treat CD being cared for at clinical centers across Italy.
Body size and condition, not allochrony, affect temporal reproductive patterns in a prolonged breeding anuran
Authors: Burgstaller Stephan , Horvath Andras , Aiglsperger Marie-Luise , Kapeller Bernhard , Spießberger Magdalena , Staufer Martina , Landler Lukas 
Published: October 2024

Abstract
Individual phenological life-history variations in the context of seasonal conditions are well documented in fishes and birds. However, amphibians, a group heavily affected by habitat loss and fragmentation, have received relatively little attention regarding research on life-history adaptations. Here we present 3 years of data on the timing of reproductive activity in a suburban European green toad (Bufotes viridis) population. We found annually consistent patterns of reproductive activity and investigated whether these were caused by allochrony or individual attributes. Body size (a proxy for age), body condition, and sex significantly affected the timing of reproductive activity. However, most individuals showed considerable overlap in their reproductive timeframe, refuting the existence of allochronic subpopulations. Our findings may indicate life-history adaptations in the direction of a faster lifestyle in response to hazardous environments. We propose to focus further research efforts on phenological variations in the context of environmental conditions, and that phenological variations should be considered more strongly in amphibian conservation efforts.
Navitor™ in Evolut™: a case report illustrating a novel approach to redo-transcatheter aortic valve implantation
Authors: Völz Sebastian , Petursson Petur , Ioanes Dan , Råmunddal Truls , Angerås Oskar 
Published: October 2024

Abstract

Background
Transcatheter aortic valve implantation (TAVI) is expanding to younger patients, and the management of valve failure is a growing clinical problem. The transcatheter heart valve (THV) of choice for redo-TAVI is a complex decision, and first reports have examined the use of the Sapien 3™ THV (Edwards Lifesciences; Irvine, CA, USA) in failed Evolut™ (Medtronic, Minneapolis, MN, USA) THV. However, several different technical approaches may be worth consideration, and the subject remains a matter of debate.

Case summary
A 73-year-old female with previous coronary artery bypass grafting, percutaneous coronary intervention (PCI), and TAVI with a 26 mm Evolut™ R THV presented with signs of heart failure. The clinical investigation revealed a severe restenosis of the THV valve and a stenosis of the left coronary main stem. The patient was successfully treated with PCI of the left main and, during the same procedure, underwent implantation of a 25 mm Navitor™ THV (Abbott; Chicago, IL, USA).

Discussion
This case presentation aims to illustrate the rationale of and necessary conditions for performing a TAVI-in-TAVI procedure with Navitor™ THV in a failed Evolut™ THV which, to our best knowledge, constitutes a novel approach to redo-TAVI.
Novel method for diagnosing takotsubo syndrome with left ventriculography using a microaxial flow pump in temporary surgical mode in a patient with cardiogenic shock: a case report
Authors: Kawakami Shoji , Nawata Eigo , Nishi Jun-ichiro 
Published: October 2024

Abstract

Background
It is reasonable to introduce a microaxial flow pump (Impella) before coronary angiography and left ventriculography (LVG) to prioritize treating tissue hypoperfusion in patients with takotsubo syndrome (TTS) and refractory cardiogenic shock. However, left ventricular (LV) unloading by an Impella device might prevent contrast media from filling the left ventricle, making it difficult to evaluate LV wall motion abnormalities during LVG.

Case summary
A 76-year-old female with ST elevations in I, II, aVL, and V1–6 on electrocardiography and severe LV dysfunction on echocardiography immediately received circulatory support with Impella CP to treat refractory cardiogenic shock. Subsequent coronary angiography showed no significant stenosis. Biplane LVG was performed using an additional pigtail catheter inserted into the left ventricle while the pump catheter remained there in temporary surgical mode, which was able to protect the motor because the purge system remained active while the pump was stopped. Left ventriculography in temporary surgical mode revealed apical ballooning with a mismatch between epicardial coronary artery perfusion and LV contraction without compromised haemodynamics. The patient was diagnosed with TTS.

Discussion
Coronary angiography and LVG are considered essential diagnostic tools to confirm TTS and exclude acute myocardial infarction. Left ventriculography with Impella temporarily set to surgical mode was able to clearly evaluate LV wall motion abnormalities without affecting haemodynamics. This case highlights that it is perfectly acceptable to prioritize Impella insertion over coronary angiography and LVG in patients with refractory cardiogenic shock in whom the differentiation between TTS and acute myocardial infarction has not yet been made.
Burden of cardiovascular disease attributable to metabolic risks in 204 countries and territories from 1990 to 2021
Authors: Chen Huimin , Liu Lu , Wang Yi , Hong Liqiong , Zhong Wen , Lehr Thorsten , Bragazzi Nicola Luigi , Tang Biao , Dai Haijiang 
Published: October 2024

Abstract

Aims
To evaluate the global cardiovascular disease (CVD) burden attributable to metabolic risks in 204 countries and territories from 1990 to 2021.

Methods and results
Following the methodologies used in the Global Burden of Disease Study 2021, this study analysed CVD deaths and disability-adjusted life-years (DALYs) attributable to metabolic risks by location, age, sex, and Socio-demographic Index (SDI). In 2021, metabolic risks accounted for 13.59 million CVD deaths (95% UI 12.01–15.13) and 287.17 million CVD DALYs (95% UI 254.92–316.32) globally, marking increases of 63.3% and 55.5% since 1990, respectively. Despite these increases, age-standardized mortality and DALY rates have significantly declined. The highest age-standardized rates of metabolic risks-attributable CVD mortality and DALYs were observed in Central Asia and Eastern Europe, while the lowest rates were found in High-income Asia Pacific, Australasia, and Western Europe, all of which are high SDI regions. Among the metabolic risks, high systolic blood pressure emerged as the predominant factor, contributing to the highest numbers of CVD deaths [10.38 million (95% UI 8.78–12.03)] and DALYs [14.52 million (95% UI 180.42–247.57)] in 2021, followed by high LDL cholesterol.

Conclusion
Our study highlights the persistent and significant impact of metabolic risks on the global CVD burden from 1990 to 2021, emphasizing the need of designing public health strategies that align with regional healthcare capacities and demographic differences to effectively reduce these effects through enhanced international collaboration and specific policies.
The influence of body mass index on biomarkers of cellular senescence in older adults
Authors: Palmer Allyson K , St. Sauver Jennifer , Fielding Roger A , Atkinson Elizabeth , White Thomas A , McGree Michaela , Weston Susan , LeBrasseur Nathan K 
Published: October 2024

Abstract
Obesity accelerates the onset and progression of age-related conditions. In preclinical models, obesity drives cellular senescence, a cell fate that compromises tissue health and function, in part through a robust and diverse secretome. In humans, components of the secretome have been used as senescence biomarkers that are predictive of age-related disease, disability, and mortality. Here, using biospecimens and clinical data from two large and independent cohorts of older adults, we tested the hypothesis that the circulating concentrations of senescence biomarkers are influenced by body mass index (BMI). After adjusting for age, sex, and race, we observed significant increases in activin A, Fas, MDC, PAI1, PARC, TNFR1, and VEGFA, and a significant decrease in RAGE, from normal weight, to overweight, to obesity BMI categories by linear regression in both cohorts (all p &lt; 0.05). These results highlight the influence of BMI on circulating concentrations of senescence biomarkers.
Mapping the genomic landscape of Prunus spp. with PrunusMap
Authors: Ksouri Najla , Moreno María Ángeles , Contreras-Moreira Bruno , Gogorcena Yolanda 
Published: October 2024

Abstract
Next-generation sequencing has fueled significant advancement in plant breeding tools, such as genome-wide association studies and single-nucleotide polymorphism (SNP) analysis. In this dynamic landscape, plant databases housing SNP markers have evolved into hubs facilitating breeding initiatives and genomic research. PrunusMap, accessible at https://prunusmap.eead.csic.es is an open-source Web application tailored for the Prunus community. Featuring a user-friendly interface, PrunusMap empowers users to seamlessly align and locate markers across multiple genome versions of Prunus species and cultivars, supporting different queries and formats. Beyond locating marker positions, it provides a comprehensive list of annotated nearby genes and proteins. This streamlined process, driven by four intuitive features ‘Find markers’, ‘Align sequences’, ‘Align proteins’, and ‘Locate by position’, significantly reduces workload and boosts efficiency, particularly for users with limited bioinformatics expertise. Moreover, PrunusMap’s versatility is underscored by its commitment to incorporate additional Prunus genome sequences, annotations, and markers upon user request.
Far-Right World Ordering from the Margins: Ethno-Ecological Degrowth and the Nation in the Swiss Democrats’ Discourse About the Natural Environment
Authors: Forchtner Bernhard , Gruber Mirjam 
Published: October 2024

Abstract
Global environmental issues can give rise to globally shared, progressive narratives. Others, such as regressive far-right actors, have obstructed such responses by reproducing exclusionary narratives. However, while substantial work on such far-right obstruction exists, comprehensive case studies on pro-environment/pro-climate far-right actors are less common. To illuminate such far-right imagination of (un)desirable patterned relationships at a worldwide level (world ordering), we offer a multimodal longitudinal analysis of articulations of environmental issues by the radical-right party Swiss Democrats between 2000 and 2022. The significance of our contribution lies in reconstructing far-right world ordering, which positions this actor as an uncorrupted outsider and, more specifically, proposes pro-environment/pro-climate, growth-critical stances coupled with xenophobia (what we conceptualize as “ethno-ecological degrowth”). Furthermore, by combining narrative theory and Habermas-inspired theory of collective learning, we reconstruct the (distortion of) the party's communication over time to aid a reconsideration of the analytical toolkit for the analysis of world ordering.
Species delimitation under allopatry: genomic insights within and across continents in Lepidoptera
Authors: Joshi Mukta , Espeland Marianne , Huemer Peter , deWaard Jeremy , Mutanen Marko 
Published: October 2024

Abstract
Delimitation of allopatric populations into species remains subjective and largely arbitrary. Many cold-adapted species from the sub-Arctic and Central and Southern European Mountain systems provide excellent models to study allopatry problem due to their patchy distributions. The same concerns many Holarctic species, which frequently show varying degrees of differentiation between continents. In this study, we analyze high-throughput target enrichment data for 10 groups of Arctic-alpine and Holarctic lepidopteran species sampled from different regions across the Holarctic realm, i.e., Fennoscandia, European Alps, Altai Mountains, and North America. We first aimed to assess whether the genetic differences in the nuclear genome reflected observed DNA barcode divergences and, secondly, whether the gap between population and species-level differences can be reliably dissected using genomic data. We compared the phylogenetic trees and uncorrected pairwise genetic distances obtained from target enrichment and mitochondrial COI barcodes and performed a suite of population genetic and species delimitation analyses to further explore patterns of intraspecific variation in our study species. We observed that in about one-half of the cases, DNA barcodes showed phylogenetic relationships similar to the target enrichment markers. Nuclear genetic differentiation varied among the populations analyzed, from low differentiation of geographically separated populations to the deeper separation of some Nearctic populations and Arctic-alpine disjunction in the populations from Fennoscandia and Southern European mountains. Our results highlight the need for consistent delimitation of allopatric populations, especially given the prevalence of distributional discontinuities across species. Large sets of standard genetic markers provide a very promising avenue towards this goal.
Optimizing Scarce Resources through Collaboration
Authors: Shaligram Deepika , Sarvet Barry , Straus John H. 
Published: October 2024

Abstract
There is a dearth of child and adolescent psychiatrists across the United States. Pediatric primary care providers (PPCP) who try to bridge this gap typically lack the requisite training and relationships with community mental health systems to effectively manage children with psychiatric disorders. The Massachusetts Child Psychiatry Access Program (MCPAP) is a public system providing resources to enable PPCPs to treat psychiatric disorders of mild-moderate severity, thus conserving scarce child psychiatry resources for more complex and severe conditions. MCPAP delivers on-demand telephone consultation, expedited outpatient psychiatric evaluation, community resource navigation, and educational services to PPCPs across Massachusetts. Since its inception in 2004, MCPAP has become a predominant model for improving access to child psychiatry care and has been replicated in 49 US states. MCPAP receives high PPCP satisfaction and supports widespread children’s mental health screening and access to care for maternal depression, adolescent substance use disorders, and autism spectrum disorders.
Communicating and Interacting With Journal Editors
Authors: McDermott Mary M. 
Published: October 2024

Abstract
Communication between authors and journal editors is an essential component of the manuscript submission, revision, and publication processes. This chapter summarizes journal expectations and editorial priorities for these communications and provides suggestions to ensure a transparent and thorough manuscript evaluation by the editors. Specific types of communication addressed in this chapter include presubmission inquiries, manuscript cover letters, manuscript submission, editor communications after manuscript submission, author responses to editor and reviewer requests for manuscript revisions, and postacceptance communications with journal editors. The chapter includes a table summarizing types of author-editor communications and recommendations for the appropriate content to include for each communication type.
Plagiarism
Authors: Kibbe Melina R. 
Published: October 2024

Abstract
Understanding plagiarism, duplicate submission, and their related issues is paramount for everyone in an academic field. This chapter discusses plagiarism, which may be the most common form of research misconduct and occurs throughout all aspects of the written word, including essays, grant applications, published articles, and other reports. The ramifications of plagiarism can be severe and may adversely affect an academic career but, as this chapter explains, understanding the types of plagiarism and the principles of good scholarship can help authors avoid this type of misconduct. In addition to defining plagiarism and its scope in academic publications, this chapter addresses different types of plagiarism, methods to detect plagiarism, consequences of plagiarism, best practices to avoid plagiarism, and use of plagiarism detection software.
Data Sharing
Authors: Bauchner Howard , Fontanarosa Phil B. 
Published: October 2024

Abstract
Data sharing is a process by which investigators of a scientific study agree to share their data and related information with other researchers. This chapter provides information on data sharing and the responsibilities of authors related to data sharing as required by journals and funders. The key concepts, potential benefits and concerns, and ethical and practical issues related to data sharing are discussed. The various data sharing policies among journals are described, ranging from requiring authors to commit to data sharing as a condition of considering a manuscript for possible publication to only requiring that authors provide a statement about their willingness and plans to share data or not. In addition, recommendations are provided for authors of manuscripts based on shared data that they have obtained and reanalyzed to ensure that the original data sources and original investigators are clearly described and transparently reported and credited.
Neurobiology of cognitive dimensions
Authors: Baune Bernhard T. 
Published: October 2024

Abstract
Neurobiology of cognitive dimensions demonstrates how emotional cues and the states and traits of emotions profoundly influence key elements of cognitive function, including orientation, selective attention, working memory, and cognitive control. It illustrates how the memory network (AM) and the cognitive control network account for specific symptom dimensions of depression. It reviews the neural underpinnings of social cognition that characterize the nature of human social functioning, including self-referential processing, moral emotion, and social decision-making, as well as neural circuitries underlying negative bias, oversensitivity to negative feedback, and hyposensitivity to reward in major depressive disorder. It extends its review into molecular underpinnings of cognitive function including monoamines, molecules of the immune system, the stress-response axis, and correlates of gene expression and epigenetics.
Mid-term outcomes of distal tibial oblique osteotomy in patients with rheumatoid arthritis: A report of three cases
Authors: Noguchi Takaaki , Hirao Makoto , Ebina Kosuke , Etani Yuki , Okamura Gensuke , Sakata Manabu , Miura Taihei , Okada Seiji , Hashimoto Jun 
Published: October 2024

ABSTRACT
Although distal tibial oblique osteotomy (DTOO) has usually been indicated for noninflammatory diseases such as osteoarthritis, we encountered three patients with rheumatoid arthritis (RA) who underwent DTOO. We evaluated radiographic parameters and clinical scores, including self-reported scores for the foot and ankle [self-administered foot evaluation questionnaire (SAFE-Q)] and the Japanese Society for Surgery of the Foot (JSSF) ankle/hindfoot scale. In all three cases, radiographic improvements were achieved along with improvements in SAFE-Q and JSSF scores after mid-term follow-up. Supramalleolar osteotomy including DTOO could be indicated even for inflammatory diseases such as RA if erosive changes are not evident in the ankle joint.
The next-generation sequencing—chess problem
Authors: Zeitler Leo , Goldar Arach , Denby Wilkes Cyril , Soutourina Julie 
Published: October 2024

Abstract
The development of next-generation sequencing (NGS) technologies paved the way for studying the spatiotemporal coordination of cellular processes along the genome. However, data sets are commonly limited to a few time points, and missing information needs to be interpolated. Most models assume that the studied dynamics are similar between individual cells, so that a homogeneous cell culture can be represented by a population-wide average. Here, we demonstrate that this understanding can be inappropriate. We developed a thought experiment—which we call the NGS chess problem—in which we compare the temporal sequencing data analysis to observing a superimposed picture of many independent games of chess at a time. The analysis of the spatiotemporal kinetics advocates for a new methodology that considers DNA-particle interactions in each cell independently even for a homogeneous cell population.
Common Roots
Authors: Thompson Gordon Ross 
Published: October 2024

Abstract
American and British music cultures have a long and intertwined history as musicians adapted folk traditions to changes in technology and contexts. Popular music emerged as industrialization created urban audiences for enterprising musicians and entrepreneurs venues for performance. One of the most important sources for British popular music, the music hall tradition produced the first modern star in George Formby Jr whose recording and film career spanned the first half of the twentieth century. British musicians such as Ken Colyer and Acker Bilk imitated early American jazz to create the musical phenomenon they called Trad. Delving further into American folk culture, Lonnie Donegan brought skiffle: British imitations of Black American folk music that began to morph under the influence of rock ’n’ roll.
Where Stones Roll
Authors: Thompson Gordon Ross 
Published: October 2024

Abstract
Mick Jagger understood that the Rolling Stones were reinterpreting Black American blues for White British audiences and that they were tapping into adolescent sexuality. He and Keith Richards traveled from Dartford, 18 miles downriver from London, to see Blues Incorporated in Ealing, which was where they encountered Brian Jones from Cheltenham. When the BBC scheduled Blues Incorporated for a radio show in July 1962, Jagger, Richards, and Jones formed the Rollin’ Stones to fill their weekly spot at the Marquee Club. By early 1963, they had acquired bassist Bill Wyman and drummer Charlie Watts for gigs at the Marquee, the Flamingo, and soon at Giorgio Gomelsky’s Crawdaddy Club in Richmond. That was where Andrew Oldham heard them and conspired with Eric Easton to manage the band and find a recording contract. At the core of this arrangement, however, English class prejudice shaped the band’s internal social dynamics.