bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed tomographic features of Morel-Lavallée lesions in 3 cats
Authors: Dziedzic-Nyrka Natalia , Dancer Sumari , Kaipak Emma Fredholm , Nowak Lina , Pinilla Manuel , Carrera Ines , Garcia-Pertierra Sofia , Clements Dylan N. , Schwarz Tobias 
Published: October 2024

Abstract

OBJECTIVE
To describe the CT features of Morel-Lavallée lesions (MLLs) and their association with trauma in cats. This study aimed to investigate whether MLL fluid in cats accumulates between the dermis and deep fascia near superficial trauma, exhibits a vertical attenuation gradient, and shows no or only mild contrast enhancement on CT images.

ANIMALS
3 young cats: a 1-year-old neutered male domestic shorthair cat, a 2-year-old neutered male domestic shorthair cat, and a 3-year-old neutered female British Shorthair cat.

CLINICAL PRESENTATION
The clinical presentation of the 3 cats in the study involved recurrent swelling and fluid accumulation affecting at least 1 pelvic limb following trauma.

RESULTS
In all cases, there was a fluid-filled space deep to the skin and superficial subcutaneous layer but superficial to the deep fascial plane overlying the muscular component of the pelvic limbs. The MLL fluid had a vertical attenuation gradient and no or only mild contrast enhancement.

CLINICAL RELEVANCE
Morel-Lavallée lesions are often initially overlooked, likely due to distraction by concomitant significant bone injuries, and can be mistaken for hematomas, seromas, subcutaneous edema, contusions, or cellulitis, leading to less aggressive treatment. If left untreated, MLLs present a significant risk of extensive skin necrosis compared to other types of subcutaneous swelling.
Describing Adult Heart Failure Patients-Assessment of Real-Life Data in Two Sites
Authors: Petrov I. , Konstantinov V. , Dosev L. , Jekov M. , Penchev D. , Genkova K. 
Published: October 2024

Abstract

Background
There is a lack of local clinical epidemiological data describing the different heart failure (HF) phenotypes in Bulgaria.

Objective
Our goal was to describe the demographic and clinical characteristics of patients with HF in two cardiological hospitals. The primary objective was to describe the demographic and clinical characteristics of patients with HF in two cardiological hospitals. The secondary objective was to further specify the profile of chronic HF patients by describing HF phenotype and the current treatment patterns of hospitalized patients. Primary and secondary outcome measures corresponding to the objectives were descriptive in nature.

Methods
This was a retrospective non-interventional study based on secondary anonymous pooled database analyses on management of patients with HF. The retrospective data was provided by Sqilline's Danny Platform® – analytics AI (Artificial Intelligence) platform for real-world data.

Results
The total number of patients with heart failure as main diagnosis or as comorbidity, or heart failure patients, treated on outpatient basis was 1313 (8%) as of 31th of March, 2019. The number of patients with heart failure as main diagnosis in the inpatient care was 413. The mean age of the patients was 69.77 years and more than 50% of hospitalized patients were males. Ejection fraction was available in 352 HF patients in the inpatient care as follows: 40-49% in 48 patients, less than 40% in 67 patients and more than 50% in 240 patients. The most frequently observed comorbidity in hospitalized patients with two or more comorbidities (66.1%) was as follows: hypertensive heart disease with heart failure (78.0%), atrial fibrillation and flutter (42.1%).

Conclusions
We succeeded in describing the demographic and clinical characteristics of 413 HF patients in Bulgaria. Digitalization in healthcare is an unmet need which should be addressed on a broad societal scale requiring all stakeholders to be involved.
Patients With HIV and Tuberculosis Coinfection, Treated in the Specialized Hospital for Infectious and Parasitic Diseases in Sofia, Bulgaria, for the Period 2017-2019
Authors: Strashimirov D. , Milanov Vl. , Yordanova R. , Tcherveniakova T. , Yancheva-Petrova N. 
Published: October 2024

Abstract

Background
Infection with human immunodeficiency virus (HIV) is the most powerful risk factor known to predispose to Mycobacterium tuberculosis infection and further progression to active disease, which increases the risk of latent TB reactivation. TB is one of the most common opportunistic infections worldwide.

Aim
The objective of the study was to describe the main clinical characteristics of the HIV – positive patients, examined for TB for 2 years (January 2017-January 2019), as well as to delineate the clinical characteristics and treatment of patients with bacteriologically confirmed TB who were treated for it, analyze characteristics of the results from the microbiological tests performed and, further, describe the patients with multidrug – resistant tuberculosis.

Study design
This was a prospective cohort study

Methods
Diagnosis was based on clinical, radiological, and microbiological data, such as smear microscopy, culture, and rapid molecular methods (Xpert MTB/RIF).

Results
The baseline CD4+ count of the patients was significantly lower compared with the other patients without coinfection (86 ± 138 cells/μcl). Acute inflammatory response Syndrome was observed in 9 patients (30%). Multidrug-resistant (MDR) M. tuberculosis was presented in three patients (20%). The predominant localization was pulmonary tuberculosis in 12 patients (80%). Six of them (50%) tested positive for MTB. The extrapulmonary involvement engaged lymph nodes in two patients and the CNS- in one.

Conclusion
TB is a disease of advanced immune suppression. Factors predicting the development of IRIS syndrome included low CD4 count, delay of diagnosis, HIV/ HCV coinfections, infection with MDR Mycobacterium tuberculosis. The principal location was pulmonary; MTB was isolated in 50% of those cases. TB meningitis should be suspected in patients with advanced immune deficiency presented with progressive neurologic deficiency changes of consciousness, and meningeal irritation.
Perception Towards the COVID-19 Vaccine Among the Paramedical Staffs
Authors: Balamanikandan P. , Shetty P. , Shetty U. A. 
Published: October 2024

Abstract

Introduction
Broad access to efficacious immunizations is important for mitigating the COVID-19 pandemie. Healthcare personnel, particularly paramedical workers, may be more susceptible to infection during the covid pandemic due to a variety of causes. The purpose of this research is to assess paramedical staff members' opinions on the COVID-19 vaccine.

Methods and material
A research study was conducted on paramedical personnel at A B Shetty Memorial Institute of Dental Sciences in Mangalore, India, using an online survey and SPSS 21 for data analysis. The survey included questions about vaccination knowledge, type, and dosage based on literature and international recommendations.

Results
The average age of the 61 participants in the research was 45.23 ± 9.66 years, with 43 females and 18 men. While all research participants knew that the COVID-19 vaccine is accessible in India, only 59% were aware of the range of vaccines that are developed and produced in India. Of those surveyed, 42.6% felt comfortable taking the COVID-19 vaccination made in the nation. Participants assessed their likelihood of contracting the illness even after immunization as high (24.6%) and low (39.3%). Of those who have received COVID-19 immunization, 55.7% believe that adverse effects might occur.

Conclusions
The World Health Organisation (WHO) is lowering infection rates and developing a COVID-19 vaccine. Paramedical Staff who worked in the hospital are more vulnerable because of patient interaction and insufficient training on infection prevention.
The Effect of Night Shift Work on Health of Healthcare Workers
Authors: Cekova I. , Stoyanova R. , Marinova E. , Vangelova K. 
Published: October 2024

Abstract

Objectives
Night shift work and long working hours are associated with increased health risk. The aim of the study was to follow the effects of night shift work on morbidity of hospital healthcare workers (HCWs), determinants of ill health and mediating factors.

Materials and methods
A cross-sectional anonymous survey, comprising 2,690 HCWs and including information on individual and behavioral variables, working hours, shift system, and sleep quality was carried out. The health status questionnaire included a list of 13 groups of diseases.

Results
Great proportion of the studied HCWs had night shifts, often 12-hour and long working hours weekly. Cardiovascular diseases (CVDs) were with the highest prevalence, followed by digestive and endocrine diseases. The proportion of chronic diseases was higher with ex-night and night shift workers, reaching statistical significance for CVDs. Odd ratios (OR) showed increased risk of CVDs (OR = 1.98; ρ < 0.01), endocrine, digestive, mental and malignant diseases with night work. Sleep quality index was statistically significantly associated with CVDs, endocrine and digestive diseases and mental illness, and higher BMI – with CVDs and endocrine diseases. In conclusion, our data confirmed the increased health risk in HCWs, working night shifts and long working hours, especially for CVDs, with a mediating effect of their sleep quality.
Exploring Therapeutic Potential of Malcolmia Aegyptiaca Spr. and Matthiola Livida DC. Extracts in Rat Models Using Hot-Plate, Writhing and Carrageenan-Induced Paw Edema Tests
Authors: Chouikh A. , Ben Ali A. , Bousbia Brahim A. 
Published: October 2024

Abstract

Background
Malcolmia aegyptiaca (locally known as El Harra) and Matthiola livida (locally known as Chegara) are medicinal plants traditionally used to relieve pain and reduce inflammation. Little is known about the flavonoid content or the analgesie and anti-inflammatory properties of these plants.

Aims
The aim of the study was to explore the natural therapeutic potential of two xerophytic plants, M. aegyptiaca Spr. and Matthiola livida DC, for analgesic and anti-inflammatory activities using hot-plate, writhing and carrageenan-induced paw edema tests.

Materials and Methods
Flavonoid content was quantified using the AICI3 as reagent. Analgesic activity was assessed using hot-plate (in concentrations of 30 to 80 mg/kg) and writhing tests (20 and 40 mg/kg) in the rats treated. Anti-inflammatory activity was evaluated using the carrageenan-induced paw edema model in rats treated with two doses (25 and 50 mg/kg) of the two plant extracts.

Results
M. livida extract had a higher flavonoid concentration compared to M. aegyptiaca extract. Both the M. aegyptiaca and M. livida extracts exhibited dose-dependent analgesic effects in the hot-plate test, with higher doses inducing a stronger and more sustained analgesia. M. aegyptiaca extract displayed weaker dose-dependent anti-nociceptive effects in the writhing test compared to the standard NSAID indomethacin. The anti-nociceptive effects of the M. livida extract were mainly observed at the higher dose in the writhing test. Both extracts demonstrated dose-dependent anti-inflammatory activity in the carrageenan-induced paw edema model, with higher doses exhibiting greater inhibition at later time points.

Conclusion
The M. aegyptiaca and M. livida methanolic extracts possess analgesic and anti-inflammatory properties, supporting their traditional use for the pain and inflammation management. Further research is needed to elucidate the active components and mechanisms of action responsible for these activities.
Semaphorins: Novel Insights on Their Emerging Multifaceted Roles in the Evolving Landscape of Breast Cancer
Authors: Popov Ts. 
Published: October 2024

Abstract
Semaphorins, initially identified as phylogenetically conserved axon guidance molecules, comprise an extracellular signaling protein family involved in various biological events that regulate the development, tissue homeostasis and cancer progression of many organ systems. In recent years, the focus of research has expanded to investigate the roles of semaphorins in cancer. Semaphorins have emerged as crucial regulators in the pathogenesis of breast cancer (BCa). This review article aims to provide an overview of the contemporary knowledge regarding semaphorins, their diverse tumor-modulating properties, and their clinical application in BCa. Specifically, six semaphorins (SEMA3C, SEMA3E, SEMA4A, SEMA4C, SEMA4D, and SEMA7A) have been demonstrated to promote tumor progression in terms of BCa. Six additional members (SEMA3A, SEMA3B, SEMA3F, SEMA4B, SEMA6B, and SEMA6D) have been associated with tumor suppression. Several semaphorins (SEMA4C and SEMA7A) are considered putative diagnostic and prognostic biomarkers in BCa. Exploring and elucidating the intricate functions of semaphorins and their viability as therapeutic targets is an intriguing avenue of research that can improve BCa outcomes.
Steroid Treatment Focused Management of Graves’ Ophthalmopathy
Authors: Condeng Y. H. , Umar H. , Aman A. M. , Rasyid H. , Bakri S. , Iskandar H. 
Published: October 2024

Abstract

Introduction
Graves' disease (GD) is an autoimmune disease that affects the thyroid and the eyes. Graves' ophthalmopathy (GO), an autoimmune disease, usually appears 18 months after GD diagnosis. Clinical activity and disease severity determine the strategy, with steroid treatment recommended during active disease progression.

Aim
This review aims to provide an overview of steroid therapy in the treatment of Graves' ophthalmopathy, discussing its efficacy, protocols, and considerations.

Materials and Methods
We reviewed the papers focusing on management recommendations and assessed peer-reviewed publications using the following keywords: "Graves' disease", "Graves' ophthalmopathy", "Graves' orbitopathy", "glucocorticoids".

Results and Discussion
Steroid therapy, especially glucocorticoids, is a primary pharmacologic intervention for clinically active GO. Intravenous administration has shown superior outcomes compared to oral administration, with a recommended protocol that uses a cumulative dose of 4.5 grams methylprednisolone. High-dose systemic glucocorticoids possess anti-inflammatory and immunosuppressive characteristics and are efficacious in managing moderate to severe active GO. Second-line therapies, such as methylprednisolone monotherapy or in com-bination with cyclosporine, may be considered.

Conclusion
Graves' ophthalmopathy re-quires intravenous glucocorticoids during the active phase. Intravenous glucocorticoids are more effective and better tolerated than oral glucocorticoids. Patients with Graves' ophthalmopathy require individualized treatment plans that address contraindications and side effects to improve outcomes and quality of life.
Identification and expression of microRNA-34a-3p and its target Rapamycin-insensitive companion of mTOR (RICTOR) in polycystic ovarian syndrome in South Indian population
Authors: Saravanan Manya , P Ameya K , P Ashikha Shirin Usman P , Sekar Durairaj 
Published: October 2024

Abstract

Objectives
Polycystic Ovarian Syndrome (PCOS) is a complex condition affecting 4% to 26% of the world-wide population and is characterized by enlarged ovaries and cysts. These cysts are actually immature ovarian follicles that have failed to mature and release an egg, which is a process known as anovulation. This study aims to explore the potential of miRNA as therapeutic and diagnostic biomarkers for PCOS, focusing on the identification and expression analysis of novel candidates like miR-34a-3p and its target Rapamycin-insensitive companion of mTOR (RICTOR). The objective is to enhance our understanding of the molecular mechanisms associated with PCOS, particularly the roles of miRNAs in its pathogenesis. In future, we plan to test miR-34a-3p mimics/inhibitors and RICTOR downregulation to improve insulin sensitivity and ovarian function. We will also explore combined therapies and conduct trials to assess their efficacy and safety in PCOS patients, aiming to develop practical treatments for PCOS.

Methods
National Centre for Biotechnology Information (NCBI) database, TargetScan, and miRbase were explored to identify the novel miRNA candidates, resulting in the discovery of miR-34a-3p. Secondary structure was constructed using RNA Fold, and Ct and melt curve analysis assessed its statistical expression levels. Additionally, similar research was conducted to analyze the expression levels of RICTOR, a target of miR-34a-3p.

Result
The secondary structure showed miR-34a-3p has a minimum free energy of −47.20 kcal. Additionally shows dysregulation in both miR-34a-3p and RICTOR in individuals with PCOS. Furthermore, overexpression of RICTOR and decrease in miR-34a-3p levels suggest their possible role in the pathogenesis of PCOS.

Conclusion
In PCOS, miR-34a-3p is downregulated, and there’s an inverse relationship between miR-34a-3p and RICTOR levels. qRT-PCR results showed high RICTOR expression in PCOS patients. RICTOR plays a crucial role in the mTOR pathway, affecting insulin signaling, metabolism, and cellular growth, which are all implicated in PCOS.
Predictors of mortality in patients with early versus late onset of septic shock. A prospective, observational and comparative pilot study
Authors: Botoș Ioana Denisa , Pantiș Carmen , Negrău Marcel Ovidiu , Bodolea Constantin , Botea Mihai Octavian , Hirișcău Elisabeta Ioana , Puia Cosmin Ion 
Published: October 2024

Abstract

Introduction
Outcome and predictors of early- and late-onset septic shock are still controversial. The aim of the study was to compare the relevant predictors of 28-day mortality in early- and late-onset septic shock and other non-septic critical illnesses.

Material and Methods
We conducted a prospective, observational, pilot study. A group of 46 patients with early septic shock and 42 nonseptic critically ill patients from the emergency department and 56 patients with late septic shock from the hospital were enrolled. On admission to the ICU, the most important potential predictors of 28-day mortality were assessed.

Results
In terms of predicting 28-day mortality, a higher mNUTRIC score was the only common predictor for all three groups. Multi-drug resistant (MDR) bacterial aetiology was a common predictor in both forms of septic shock. Older age, female gender, increased neutrophilto-lymphocyte ratio (NLR) and increased need for vasoactive agents were common predictors in late septic shock and non-septic critically ill patients. Increased red blood cell distribution width coefficient of variation (RDW-CV) was predictor in early septic shock and non-septic critically ill patients. Central venous-arterial carbon dioxide difference (Pcv-aCO2) was predictor in patients with early septic shock. Inflammatory index and MDR carrier status were predictors in non-septic critically ill patients.

Conclusions
A higher mNUTRIC score is a predictor of 28-day mortality in early and late septic shock and in critically ill non-septic patients. MDR aetiology was predictive of 28-day all-cause mortality in both types of septic shock, and Pcv-aCO2 was predictive in patients with early septic shock.
Analysis and Research on Color Encoding and K-means Clustering Algorithm in Lingnan Landscape Design
Authors: Tan Hongyan 
Published: October 2024

Abstract
As a prominent visual phenomenon, the color environment influences the landscape design of the Lingnan region in three aspects: shape, color, and texture. The purpose of this paper is to examine the landscape nature of color by analyzing the psychological perception characteristics of color and the evolution of Lingnan’s color landscape system. We propose color clustering extraction methods for both single and batch Lingnan landscape images, combining them with color space conversion algorithms like RGB and YIQ to extract colors and segment Lingnan landscape images. We look at the performance parameters of various reconstructed images at various compression ratios. We also draw the performance convergence curves of the clustering algorithm, the JPEG, and the JPEG2000 algorithms to talk about how well they code. Taking the Lingnan region (Guangzhou) as the main object of analysis, we divide the regional color qualities and analyze the evolution and development of landscape color characteristics in the Lingnan region. Most of the Lingnan architectural landscapes have color brightness values in the medium-high range of 5-7. For wall color brightness, most of the brightness class level values are in the high brightness range of 7–10, followed by the medium brightness range of 4–7, and a small portion is in the low brightness range of 1-3.
Research on the Teaching Effect of Virtual Reality Technology in Simulated Vocal Performance Environment
Authors: Yi Heng 
Published: October 2024

Abstract
Traditional teaching methods are often relatively difficult to meet the diverse learning needs of students. For the status quo of vocal music teaching, this paper promotes the development of vocal music teaching in colleges and universities through the use of VR technology. Systematically analyzing the relationship between vocal music and virtual reality technology and its characteristics, the interrelation between the two is summarized. According to the principle of camera imaging to collect samples, after using the SIFT algorithm to detect and match the feature points of the collected samples so as to determine the spatial location of these feature points, realize the camera calibration, and obtain the sparse point cloud. The obtained sparse point cloud model is stored in PLY format files, and the PLY format files are imported into the Unity3D platform for color rendering to complete the construction of the vocal performance scene. The effect of vocal music teaching combined with VR technology was analyzed using statistical methods. The data show that the vocal music teaching mode combined with VR technology (ANOVA value 22.65) is significantly better than the traditional teaching mode (ANOVA value 27.85) in terms of the accuracy of students’ vocal performance speed, in addition to the same in terms of the comparison of the mastery of vocal music knowledge and skills. This study improves the traditional oral teaching method of music and traditional vocal music teaching mode and also breaks the limitations of time and space, providing more practice opportunities for the majority of music learners.
Research on the Integration of Laban Movement Theory and Multimedia Technology to Promote the Cultural Inheritance of Chinese Opera
Authors: Zhang Muchen , Yang Yi 
Published: October 2024

Abstract
In the background of the new era, the rapid development of networking and digitization has played a certain role in promoting the dissemination and development of opera culture. First, we normalize the opera action data of the recorded opera performers. Then, based on Laban’s movement theories, we propose a parallel one-dimensional convolutional network and recurrent neural network model that adds a way for attention to splice, encode, and decode the time sequences in the opera action data. Next, we employ the full connection layer to generate a sequence of Laban opera action symbols, enabling the recognition of Laban opera actions. Ultimately, we integrate the model with virtual reality technology to establish a virtual opera learning system. The model tests show that the suggested Laban opera action recognition and automatic generation method works better than the rule-based and template-matching methods for the same period. There is a significant difference (P<0.05) between the experimental group that used the opera virtual learning system and the control group, which was made up of opera fans who learned the old-fashioned way. This was seen in the post-test of technical quality, which looked at posture and foot movements. This paper’s designed system can enhance the interest and impact of opera enthusiasts in learning opera culture while also offering a reference path for the transmission of opera culture and related fields.