bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Sojourn Time Distributions in Modeling HIV/AIDS Disease Progression
Authors: Asena Tilahun Ferede , Goshu Ayele Taye 
Published: December 2017

Summary
An application of semi-Markov models to AIDS disease progression was utilized to find best sojourn time distributions. We obtained data on 370 HIV/AIDS patients who were under follow-up from September 2008 to August 2015, from Yirgalim General Hospital, Ethiopia. The study reveals that within the “good” states, the transition probability of moving from a given state to the next worst state has a parabolic pattern that increases with time until it reaches a maximum and then declines over time. Compared with the case of exponential distribution, the conditional probability of remaining in a good state before moving to the next good state grows faster at the beginning, peaks, and then declines faster for a long period. The probability of remaining in the same good disease state declines over time, though maintaining higher values for healthier states. Moreover, the Weibull distribution under the semi-Markov model leads to dynamic probabilities with a higher rate of decline and smaller deviations. In this study, we found that the Weibull distribution is flexible in modeling and preferable for use as a waiting time distribution for monitoring HIV/AIDS disease progression.
The effect of integrated tillage of light soil on potato yields
Authors: Walkowiak Ryszard , Podsiadłowski Stanisław , Czajka Michał 
Published: December 2017

Summary
Excessive compaction of soil has an adverse effect on its aggregate structure, and as a result also on the yields of various crops. To prevent this negative impact, diverse methods of limited tillage are applied. However, these methods are not effective when cultivating sandy soils of very low natural porosity. An original integrated tillage method for such soils has been developed at the Poznań University of Life Sciences. This paper presents a comparison of yields and quality of three popular potato cultivars following the application of conventional and integrated tillage methods. The experiment shows that integrated tillage contributes to an increase in potato yield by providing better conditions for tuber growth.
Crystal structure of methyl (Z)-2-(5-fluoro-2-oxoindolin-3-ylidene)hydrazine-1-carbodithioate, C10H8FN3OS2
Authors: Li Xin-Hong , Qin Zhao-Xian , Cao Sheng-Li 
Published: December 2017

Abstract
C10H8FN3OS2, monoclinic, P21/c (no. 14), a = 6.2909(2) Å, b = 7.4103(2) Å, c = 24.7079(6) Å, β = 97.396(2)°, V = 1142.24(6) Å3, Z = 4, R
gt(F) = 0.0375, wR
ref(F
2) = 0.1014, T = 293 K.
Distribution of Lichen Species of the Genus Lepraria in the Knyszyn Forest (Ne Poland) in Different Forest Plant Communities
Authors: Matwiejuk Anna 
Published: December 2017

Abstract
The aim of the study was to evaluate the distribution of lichen species of the genus Lepraria in Knyszyn Forest (NE Poland) to different forest plant communities. Six species of Lepraria [L. eburnea J. R. Laundon, L. elobata Tønsberg, L. incana (L.) Ach., L. jackii Tønsberg, L. lobificans Nyl. and L. vouaxii (Hue) R. C. Harris] recorded from Knyszyn Forest. Lepraria eburnea is a new species for the studied area. The most common species were Lepraria incana and L. lobificans. Among the studied forest communities the richest in species (5 species of Lepraria) were oak-hornbeam forest (Tilio-Carpinetum), and the least species-rich (2 species) were maple-linden slope forest (Aceri-Tilietum), alder carr (Carici elongatae-Alnetum) and spruce forest (Sphagno girgensohnii-Piceetum). The richest lichen diversity in the Knyszyn Forest was found on deciduous trees such as Carpinus betulus L. and Quercus robur L. (4 species), Tilia cordata Mill. (3 spp.), and conifers such as Picea abies (L.) H. Karst. and Pinus sylvestris L. (3 spp.).
Plädoyer für einen einheitlichen, aber nicht einförmigen Sprachbegriff: Zur aktuellen Rezeption des Nähe-Distanz-Modells
Authors: Selig Maria 
Published: December 2017

AbstractThe present contribution discusses the legacy of Peter Koch and Wulf Oesterreicher and analyzes the reception of their model of communicative immediacy and communicative distance. It is argued that the model, despite being related to the tradition of research on spoken language and oral communication, does not intend to offer a descriptive matrix of media-related phenomena, but gives a systematic account of the anthropological (and not necessarily mediarelated) parameters regulating the creative, reflexive and social activity of defining the communicative situation. In focusing on the multi-dimensional variational space in between, what may also be called the poles of informal and formal communication, and in highlighting the parameters directly related to the strategies of verbalization, the model offers the possibility to better understand the dialectics between the actual processing of oral or written language and the variational norms regulating the verbal behavior in the consistent but not uniform communicative space.
A la búsqueda de los textos olvidados. Los orígenes de la modernidad discursiva en la historia del español
Authors: Aguilar Rafael Cano 
Published: December 2017

AbstractThe transition between the seventeenth and eighteenth centuries has been a period of very little, if any, knowledge for the historians of Spanish. Between the classical period of the Siglo de Oro and the beginning of modernity in the eighteenth century there was no event of interest at that time. Modern research on the history of Spanish vocabulary or texts shows that from1675 onwards we can find forms and discursive traditions that are central in modern Spanish, while processes fromearlier periods continued. In this paperwe will analyze some of themost significant (non-literary) texts of those years, and try to establish their defining linguistic and discursive traits.
Translocated Danish in Northern Europe: The case of Faroe Danish and Dano-Norwegian
Authors: Kühl Karoline 
Published: December 2017

AbstractThe paper contains a descriptive analysis of the development of translocated Danish in historical Norway and the Faroes within a framework of postcolonial linguistic development, namely the ‘Dynamic Model of Postcolonial Englishes’ (Schneider 2009), originally proposed to cover the evolution of postcolonial varieties of English. The paper compares the socio-political development of the two territories and their relationship with Denmark, the identity constructions of the speakers, the sociolinguistic setting with regard to attitudes and language contact and, finally, the linguistic characteristics of the local varieties of Danish. Despite the fact that neither the Faroes nor Norway had actual colonial status, the development from historical Dano-Norwegian to today’s Bokmål follows a postcolonial path closely in that it shows a completed advancement from a translocated Danish to an indigenous variety, Bokmål. In contrast, the comparison with Norway and the other postcolonial situations which the ‘Dynamic Model’ is based on, shows that the evolution of Faroe- Danish does not follow a postcolonial path. This local variety of Danish seems to be best characterized as a lingua franca learned as an (early) L2 that is entrenched within the Faroese society which shows but few signs of nativization.
Au coeur d’un « carrefour des langues »
Authors: Padilla-Moyano Manuel 
Published: December 2017

RésuméDu point de vue historique, le monolinguisme n’a pas été la règle en Europe (Braunmuller/Ferraresi 2003). Lorsqu’il s’agit d’évoquer des communautés plurilingues, nous nous référons le plus souvent a des contextes commerciaux ou à des sociétés multiethniques. Cependant, le present cas d’étude illustre le plurilinguisme dans une communauté de paysans, ethniquement homogène : l’ancienne province basque de Soule. Ce travail analyse deux traits du basque souletin résultant du contact avec l’occitan gascon : a) la diffusion d’un suffixe de dérivation marquant le genre non-grammatical ; et b) l’émergence d’un nouveau groupe de participes. Nous soulignons l’importance du contact linguistique parmi les facteurs qui ont façonné le basque souletin des derniers siècles ; plus recemment, la forte identité ethnolinguistique des Souletins a provoqué un certain refus de la norme standard.
The Holiness Redaction of the Primeval History
Authors: Arnold Bill T. 
Published: December 2017

Zusammenfassung:Stephen A. Kaufmann hat gezeigt, dass die Autoren der Tempelrolle eine Vielzahl editorischer Techniken angewendet haben wie Komposition, Zusammenführung (unterschiedlicher Varianten) und ausgedehnte Zitation. Diese Techniken stellen eine heuristische Parallele zu der Komposition des Pentateuch dar, wie sie die zeitgenössische Forschung annimmt. Der Artikel überprüft diese Annahme am Beispiel der Komposition von Gen 1–11 unter der Annahme eines Heiligkeits-Redaktors, der Quellen von P und Nicht-P heranzog.
In Vino Veritas? Critiquing Drunkenness and Deceit in Micah and Isaiah
Authors: Bautch Richard J. 
Published: December 2017

Zusammenfassung:Dieser Beitrag untersucht die Korrelation zwischen Trunkenheit und Täuschung, zwei Begriffen, die in der Hebräischen Bibel durch שׁכר und שׁקר ausgedrückt werden. Hervorstechende Kennzeichen sind die orthographische Ähnlichkeit beider hebräischer Wörter sowie ihre Nähe zueinander in Texteinheiten dreier prophetischer Bücher. Ich komme zum Schluss, dass שׁכר und שׁקר durch diejenigen, die für Micha, Jesaja und Habakuk verantwortlich sind, literarisch verbunden wurden, um einen Zustand der Trunkenheit und Täuschung zu suggerieren, der mit Israels korrupter Oberschicht und seinem oft eigensinnigen Volk assoziiert wird. In dieser Kritik am Gemeinwesen gehen die beiden dreiradikaligen Wurzeln eine feste Verbindung ein, sodass שׁכר und שׁקר entsprechend einem von Bezalel Porten im Rahmen seiner Jeremia-Studien geprägten Begriff zu einem »Wortklangpaar« (
A Note on the Implications of Two Mari Texts (ARM 26/1 106 and ARM 25 143) for Benaiah’s Leonine Episode in 2Sam 23:20 par. 1Chr 11:22
Authors: Price Joe H. 
Published: December 2017

Zusammenfassung:Sowohl 2 Sam 23,20 als auch 1 Chr 11,22 berichten von Benajas Kampf mit einem Löwen, einem Detail, das in einer Liste großer Kriegstaten deplatziert wirkt, aber in die Welt des alten Nahen Ostens passt. Dieser Beitrag untersucht zwei Mari-Texte (ARM 26/1 106 und ARM 25 143), die Hinweise darauf liefern, dass Taten wie Benajas Kampf in Palastarchiven aufgezeichnet und überliefert wurden. Er schlägt vor, dass Benajas Tat in ähnlicher Weise festgehalten und später in der Quelle für 2 Sam 23,20 und 1 Chr 11,22 aufgegriffen wurde.
Triple-A syndrome: a wide spectrum of adrenal dysfunction
Authors: Roucher-Boulez Florence , Brac de la Perriere Aude , Jacquez Aude , Chau Delphine , Guignat Laurence , Vial Christophe , Morel Yves , Nicolino Marc , Raverot Gerald , Pugeat Michel 
Published: December 2017

Objective
Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the AAAS gene, which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: alacrima, achalasia and adrenal insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported. The objective of the present study was to characterize the various spectra of adrenal function in Triple-A patients.

Methods
A retrospective clinical and biological monitoring of 14 patients (10 families) was done in a single multidisciplinary French center. All had AAAS gene sequenced and adrenal function evaluation.

Results
Nine different AAAS mutations were found, including one new mutation: c.755G>C, p.(Trp252Ser). Regarding adrenal function, defects of the zona fasciculata and reticularis were demonstrated by increased basal ACTH levels and low DHEAS levels in all cases regardless of the degree of glucocorticoid deficiency. In contrast, mineralocorticoid function was always conserved: i.e., normal plasma renin level associated with normal aldosterone level. The main prognostic feature was exacerbation of neuropathy and cognitive disorders.

Conclusions
These data suggest that, in Triple-A patients, adrenal function can be deficient, insufficient or compensated. In our cohort after the first decade of life, there does not appear to be any degradation of adrenal function over time. However, patients with compensated adrenal function should be informed and educated to manage a glucocorticoid replacement therapy in case of stressful conditions, with no need for systematic long-term treatment.
Genome Assembly and Annotation of the Medicinal PlantCalotropis gigantea, a Producer of Anticancer and Antimalarial Cardenolides
Authors: Hoopes Genevieve M , Hamilton John P , Kim Jeongwoon , Zhao Dongyan , Wiegert-Rininger Krystle , Crisovan Emily , Buell C Robin 
Published: December 2017

AbstractCalotropis gigantea produces specialized secondary metabolites known as cardenolides, which have anticancer and antimalarial properties. Although transcriptomic studies have been conducted in other cardenolide-producing species, no nuclear genome assembly for an Asterid cardenolide-producing species has been reported to date. A high-quality de novo assembly was generated for C. gigantea, representing 157,284,427 bp with an N50 scaffold size of 805,959 bp, for which quality assessments indicated a near complete representation of the genic space. Transcriptome data in the form of RNA-sequencing libraries from a developmental tissue series was generated to aid the annotation and construction of a gene expression atlas. Using an ab initio and evidence-driven gene annotation pipeline, 18,197 high-confidence genes were annotated. Homologous and syntenic relationships between C. gigantea and other species within the Apocynaceae family confirmed previously identified evolutionary relationships, and suggest the emergence or loss of the specialized cardenolide metabolites after the divergence of the Apocynaceae subfamilies. The C. gigantea genome assembly, annotation, and RNA-sequencing data provide a novel resource to study the cardenolide biosynthesis pathway, especially for understanding the evolutionary origin of cardenolides and the engineering of cardenolide production in heterologous organisms for existing and novel pharmaceutical applications.
A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail inSaccharomyces cerevisiae
Authors: Buehl Christopher J , Deng Xiexiong , Luo Jianjun , Buranasudja Visarut , Hazbun Tony , Kuo Min-Hao 
Published: December 2017

AbstractThe yeast protein Shugoshin 1 (Sgo1p) senses tension between sister chromatids during mitotic chromosome alignment. A regulatory region on histone.....Mitotic fidelity is ensured by achieving biorientation on all paired chromosomes. The key signal for proper chromosome alignment is the tension between sister chromatids created by opposing poleward force from the spindles. In the budding yeast, the tension-sensing function requires that the Shugoshin protein, Shugoshin 1, be recruited to the centromeres and the neighboring pericentric regions. Concerted actions integrating proteins at centromeres and pericentromeres create highly specific Shugoshin 1 domains on mitotic chromosomes. We have previously reported that an important regulatory region on histone H3, termed the tension-sensing motif (TSM), is responsible for retaining Shugoshin 1 at pericentromeres. The TSM is negatively regulated by the acetyltransferase Gcn5p, but the underlying mechanism was elusive. In this work, we provide evidence that, when the TSM function is impaired, the histone H3 tail adopts a role that complements the damaged TSM to ensure faithful mitosis. This novel function of the H3 tail is controlled by Gcn5p, which targets selective lysine residues. Mutations to K14 and K23 ameliorate the mitotic defects resulting from TSM mutations. The restoration of faithful segregation is accompanied by regaining Shugoshin 1 access to the pericentric regions. Our data reveal a novel pathway for mitotic Shugoshin 1 recruitment and further reinforce the active role played by chromatins during their segregation in mitosis.
IMPLANTAÇÃO DE FROTA PRÓPRIA PARA TRANSPORTE NA INDÚSTRIA DE RAÇÕES: UM ESTUDO DE VIABILIDADE
Authors: Rayzer Douglas , Bissan Niloar , Fernandes Rodrigo André , Winck Cesar Augustus 
Published: December 2017

O objetivo deste artigo foi estudar a viabilidade de implantação por uma agroindústria no Oeste de Santa Catarina de frota própria de caminhões para o transporte de rações. O método utilizado na pesquisa foi indutivo, permitindo investigação com base em dados numéricos, que demonstraram a realidade do lócus de estudo. Foram verificados os custos incorridos da implantação de uma frota própria na empresa, os investimentos, custos fixos e variáveis. A partir destes dados foi realizada a análise de viabilidade de investimento através de métodos de avaliação de projetos. Concluiu-se que com a aquisição da frota, ocorreram melhorias nos serviços de entregas de rações aos clientes, em vista de que os caminhões e os motoristas são treinados pela empresa prestando um serviço personalizado, porém não existe um retorno do investimento de forma rápida e com a taxa de aplicação baseada na empresa, sendo assim é inviável a aquisição de uma frota própria.
MÚLTIPLAS CENTRALIDADES DO LAZER NOTURNO NA CIDADE DE SÃO JOSÉ DO RIO PRETO – SP.
Authors: Gomes Aylé De Mello 
Published: December 2017

O presente trabalho procura identificar a oferta de diversão noturna presente na cidade de São José do Rio Preto, suas lógicas econômicas e a possível formação de áreas centrais noturnas. Ainda nesse campo, procuramos identificar as práticas espaciais dos consumidores de diversão noturna (que são sobretudo jovens), suas formas de interação e os impactos das novas tecnologias. A articulação entre formação da cultura juvenil, cultura de consumo, o uso de redes sociais envolvem diferentes temáticas que sustentam as práticas juvenis nas cidades que acarretam o uso do espaço urbano.São José do Rio Preto é uma cidade que apresenta disparidades significativas no âmbito socioeconômico, disparidades observadas a partir da valorização imobiliária e da oferta de bens e serviços, onde estabelecimentos de diversão noturna estão inclusos.
O currículo da Naturologia à luz dos conceitos de racionalidade médica e prática integrativa
Authors: Hellmann Fernando , Grassi Leandro , Verdi Marta Inez Machado 
Published: December 2017

O bacharelado em Naturologia distingue-se no Ensino Superior brasileiro pelo estudo de práticas não convencionais de cuidado em saúde humana. Este estudo teve por objetivo analisar o currículo de Naturologia a partir dos conceitos de racionalidade médica e prática integrativa. Trata-se de pesquisa com abordagem preponderantemente qualitativa, descritiva e documental na qual foram analisados, por meio de análise de conteúdo, 51 programas de disciplinas do curso de Naturologia de uma universidade no Sul do Brasil. Discutiu-se a distribuição do número de horas do currículo alocadas às dimensões das racionalidades médicas da Medicina chinesa, ayurvédica e ocidental contemporânea, além das práticas integrativas e as disciplinas sociotécnicas e humanistas. Constatou-se que 38% da carga horária são de cunho biomédico, 37% de cunho vitalista e 25% envolvem disciplinas sociotécnicas e humanistas. Por fim, este estudo sugere a necessidade de reforma curricular e colabora para pensar em referências relativas a tais práticas de cuidado em saúde.
Application of Simplex Method to Evaluate Advertising and Performance of Quoted Multinational Corporation in Nigeria
Authors: Opusunju Michael Isaac , Akyuz Murat , Jiya Ndalo Santeli 
Published: December 2017

The study evaluate advertising and performance of quoted multinational corporations in Nigeria using simple method in order to see if firm maximize their sale volume or not. The study use historical data from the period of 2000- 2009. The period is chosen because of the availability of the data. The population of this study included all the 16 quoted multinational corporations in Nigeria and 3 multinational corporations were selected. The use Q and M for windows to analysis the data and findings indicates that Nigerian Bottling Company, PZ and Unilever Plc maximize sales through the activities of advertising in various media in Nigeria. The study suggested that Nigerian Bottling Company, PZ and Unilever Plc should concentrated in their advertising programmes and also concentrated in developing a good product quality by ensuring that their products satisfy the needs and want of the host community. Nigerian Bottling Company and PZ should try to maximize sales through advertising but Unilever Plc should not maximized sales through advertising programmes. Nigerian Bottling Company and Unilever Plc should concentrate on profit after tax through advertising and PZ should realized that advertising can maximize profit after tax.
KONSTRUKSI TRIPLE DISRUPTAN GEN PENGKODE PROTEIN FOSFATASE DAN PROTEIN KINASE Saccharomyces cerevisiae
Authors: Hermansyah Hermansyah , Susilawati Susilawati 
Published: December 2017

AbstrakKonstruksi triple disruptan pada Saccharomyces cerevisiae dibuat dengan menyilangkan (crossing) atau melakukan mating antara strain BY4739 (MATa ura3D0 leu2D0 lys2D0 kin3D::KanMX) dengan strain SH6793 (MATa ptp2D::CgHIS3 msg5D::CgLEU2 ura3-52 his3-Δ200 leu2Δ1 lys2Δ202 trp1Δ63). Dari 10 aski yang menghasilkan 40 koloni triple disruptan, hanya 3 koloni yang memiliki fenotip dapat tumbuh di media SC-his, SC-leu, dan YPDA + 100 µg/mL geniticin disulfat. Uji lanjut terhadap tiga koloni tersebut menggunakan amplifikasi PCR dan pemotongan dengan enzim restriksi NruI menghasilkan hanya satu koloni yang memiliki ptp2D. Data ini mengindikasikan bahwa kemungkinan hanya satu koloni yang memiliki triple disruptan ptp2D msg5Dkin3D yaitu koloni 7B. Kata kunci: triple disruptan, Saccharomyces cerevisiae, metode crossing (persilangan) AbstractTriple disruptant were contsructed by crossing or mating between strain BY4739 (MATa ura3D0 leu2D0 lys2D0 kin3D::KanMX) and strain SH6793 (MATa ptp2D::CgHIS3 msg5D::CgLEU2 ura3-52 his3-Δ200 leu2Δ1 lys2Δ202 trp1Δ63). Out of 10 asci generating 40 colonies which have triple disruptant, only 3 colonies showed phenotypics growing on SC-his, SC-leu, and YPDA+ 100 µg/mL geniticine disulfate medium. Further test to these three colonies by using PCR amplication and digesting by restriction enzyme NruI resulted only one colony showing ptp2D. This data indicated that only one colony had ptp2D msg5D kin3D triple disruptant, colony 7B. Keywords: triple disruptant, Saccharomyces cerevisiae, crossing method