bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of donor–recipient sex match on long‐term survival after heart transplantation in children: An analysis of 5797 pediatric heart transplants
Authors: Kemna Mariska , Albers Erin , Bradford Miranda C. , Law Sabrina , Permut Lester , McMullan D. Mike , Law Yuk 
Published: December 2015

AbstractThe effect of donor–recipient sex matching on long‐term survival in pediatric heart transplantation is not well known. Adult data have shown worse survival when male recipients receive a sex‐mismatched heart, with conflicting results in female recipients. We analyzed 5795 heart transplant recipients ≤18 yr in the Scientific Registry of Transplant Recipients (1990–2012). Recipients were stratified based on donor and recipient sex, creating four groups: MM (N = 1888), FM (N = 1384), FF (N = 1082), and MF (N = 1441). Males receiving sex‐matched donor hearts had increased unadjusted allograft survival at five yr (73.2 vs. 71%, p = 0.01). However, this survival advantage disappeared with longer follow‐up and when adjusted for additional risk factors by multivariable Cox regression analysis. In contrast, for females, receiving a sex‐mismatched heart was associated with an 18% higher risk of allograft loss over time compared to receiving a sex‐matched heart (HR 1.18, 95% CI: 1.00–1.38) and a 26% higher risk compared to sex‐matched male recipients (HR 1.26, 95% CI: 1.10–1.45). Females who receive a heart from a male donor appear to have a distinct long‐term survival disadvantage compared to all other groups.
Massive pulmonary hemorrhage before living donor liver transplantation in infants
Authors: Matsuura Toshiharu , Yoshimaru Koichiro , Yanagi Yusuke , Esumi Genshiro , Hayashida Makoto , Taguchi Tomoaki 
Published: December 2015

AbstractA massive pulmonary hemorrhage in patients with liver cirrhosis is a life‐threatening complication that may result in a contraindication of a liver transplantation because of its high mortality rate. Herein, we present two infant biliary atresia cases that successfully underwent an LDLT that was followed by intensive respiratory care for the pretransplant massive pulmonary hemorrhage. Both cases exhibited severe respiratory failure (minimum PaO2/FiO2; 46 mmHg and 39 mmHg, respectively). To arrest the bleeding, we applied a very high positive pressure ventilation treatment (maximum PIP/PEEP; 38/14 cmH2O and 55/15 cmH2O, respectively), plasma exchange, several FFP transfusions, and recombinant factor VIIa via intrapulmonary administration. In addition, we used CHDF treatment, applied HFOV transiently, and treated the patient with inhalation of nitric oxide. Although we prepared ECMO for intra‐operative use, both cases were successfully managed with conventional mechanical ventilation without using ECMO, which may have worsened the pulmonary hemorrhage due to the use of an anticoagulant. Use of an excessive positive pressure management, although it poses a risk for barotrauma, could be acceptable to arrest the pulmonary bleeding in selected cases of liver failure patients who have no time remaining before LDLT.
Interaction between sexes and between different circadian phenotypes affects lifespan in the fruit fly Drosophila melanogaster
Authors: Kawaguchi Tomoaki , Umezaki Yujiro , Ito Chihiro , Tomioka Kenji 
Published: December 2015

AbstractCircadian clocks regulate the daily temporal structure of physiological and behavioural functions. In the fruit fly Drosophila melanogaster Meigen, disruption of daily rhythms is suggested to reduce the fly's lifespan. In the present study, because pairs of mixed‐sex flies are known to show an activity pattern different from that of individual flies, this hypothesis is tested by measuring the lifespan of flies housed same‐sexually or mixed‐sexually under an LD 12 : 12 h photocycle at a constant temperature of 25 °C. The effect of housing wild‐type (Canton‐S) flies with period (per) circadian clock mutant flies is also examined because the mutant flies have different daily activity patterns. When males and females of wild‐type flies are housed together, their lifespan is substantially lengthened (males) or shortened (females) compared with same‐sex housed flies. The shortening of the lifespan in females is significantly enhanced when mated with per mutant males. The shortening effects are significantly reduced when the mixed‐sex interaction is limited for the first 5 days after emergence. A slight elongation in lifespan, rather than a reduction, occurs when wild‐type females are housed same‐sexually with per0 or perL mutant flies. In male flies, the elongation of lifespan occurs not only when wild‐type males are housed with wild‐type, per0 or perL females, but also when housed with per0 or perS mutant males. Mixed‐sex couples always show altered daily locomotor rhythms with an enhanced night‐time activity, whereas same‐sex couples show daily behavioural profiles slightly altered but essentially similar to a sum of the respective two flies. No significant correlation is found between the lifespan and reproductive capacity. These results suggest that the alteration of daily activity rhythms and sexual interaction may have significant impact on the fly's lifespan.
Performance Measurement and Cost Accounting: Are They Complementary or Competing Systems of Control?
Authors: Mohr Zachary T. 
Published: December 2015

AbstractIn the public administration literature, research on performance measurement has recognized the important place of cost accounting in relation to performance. Extant research, such as the North Carolina Benchmarking Program, supports the proposition that performance and cost accounting naturally complement each other to increase trust in performance information and increase organizational learning. Other statements about cost accounting suggest that performance measurement and cost accounting compete as systems of control. This research uses general cost accounting plan information and performance measurements in the budgets of large U.S. cities to test the competing and complementary control relationship at the organizational and service levels. It finds that performance measurements and cost accounting are negatively related at the service level, which supports the competing control system hypothesis. At the organizational level, performance and cost accounting are positively related but not at traditional levels of significance.
Barriers to early presentation of self-discovered breast cancer in Singapore and Malaysia: a qualitative multicentre study
Authors: Lim Jennifer NW , Potrata Barbara , Simonella Leonardo , Ng Celene WQ , Aw Tar-Ching , Dahlui Maznah , Hartman Mikael , Mazlan Rifhan , Taib Nur Aishah 
Published: December 2015

ObjectiveTo explore and compare barriers to early presentation of self-discovered breast cancer in Singapore and Malaysia.DesignA qualitative interview study with thematic analysis of transcripts.Participants67 patients with self-discovered breast symptoms were included in the analysis. Of these, 36% were of Malay ethnicity, 39% were Chinese and 25% Indian, with an average age of 58 years (range 24–82 years). The number of women diagnosed at early stages of cancer almost equalled those at advanced stages. Approximately three-quarters presented with a painless lump, one-quarter experienced a painful lump and 10% had atypical symptoms.SettingUniversity hospital setting in Singapore and Malaysia.ResultsPatients revealed barriers to early presentation not previously reported: the poor quality of online website information about breast symptoms, financial issues and the negative influence of relatives in both countries, while perceived poor quality of care and services in state-run hospitals and misdiagnosis by healthcare professionals were reported in Malaysia. The pattern of presentation by ethnicity remained unchanged where more Malay delayed help-seeking and had more advanced cancer compared to Chinese and Indian patients.ConclusionsThere are few differences in the pattern of presentation and in the reported barriers to seek medical care after symptom discovery between Singapore and Malaysia despite their differing economic status. Strategies to reduce delayed presentation are: a need to improve knowledge of disease, symptoms and causes, quality of care and services, and quality of online information; and addressing fear of diagnosis, treatment and hospitalisation, with more effort focused on the Malay ethnic group. Training is needed to avoid missed diagnoses and other factors contributing to delay among health professionals.
Late Cretaceous (Campanian) actinopterygian fishes from the Kristianstad Basin of southern Sweden
Authors: Bazzi Mohamad , Einarsson Elisabeth , Kear Benjamin P. 
Published: December 2015

Abstract

Although a diverse range of aquatic vertebrates are documented from the Upper Cretaceous (mid-Campanian) marine strata of the Kristianstad Basin in southern Sweden, only chondrichthyans and marine amniotes have been described in detail to date. In contrast, coeval actinopterygians are virtually unreported, yet their remains are extremely abundant at most sampled localities. A comprehensive assessment of these fossils has identified the first Late Cretaceous actinopterygian fauna from the Fennoscandian Shield, incorporating indeterminate lepisosteids, the durophagous pycnodontid
Anomoeodus subclavatus
, the predatory pachycormid
Protosphyraena
sp., a large ichthyodectid, pachyrhizodontids resembling
Pachyrhizodus
, the enchodontid
Enchodus
cf.
gladiolus
and indeterminate small teleosts. These taxa are diagnosed mainly from isolated teeth and scales, implying substantial taphonomic loss prior to burial. Moreover, the prolific recovery of actinopterygian skeletal remnants in recent excavations suggests that historical collecting biases, rather than ecological paucity, have contributed to their under-representation in the Swedish Cretaceous record. Palaeobiogeographically, the Kristianstad Basin actinopterygians show compositional resemblance to assemblages from the Northern European Platform and the Western Interior Seaway of North America, advocating distributional communication across the Boreal proto-Atlantic Ocean.
Integer Linear Programming-Based Scheduling for Transport Triggered Architectures
Authors: Äijö Tomi , Jääskeläinen Pekka , Elomaa Tapio , Kultala Heikki , Takala Jarmo 
Published: December 2015

Static multi-issue machines, such as traditional Very Long Instructional Word (VLIW) architectures, move complexity from the hardware to the compiler. This is motivated by the ability to support high degrees of instruction-level parallelism without requiring complicated scheduling logic in the processor hardware. The simpler-control hardware results in reduced area and power consumption, but leads to a challenge of engineering a compiler with good code-generation quality.
Transport triggered architectures (TTA), and other so-called exposed datapath architectures, take the compiler-oriented philosophy even further by pushing more details of the datapath under software control. The main benefit of this is the reduced register file pressure, with a drawback of adding even more complexity to the compiler side.

In this article, we propose an
Integer Linear Programming (ILP)
-based instruction scheduling model for TTAs. The model describes the architecture characteristics, the particular processor resource constraints, and the operation dependencies of the scheduled program. The model is validated and measured by compiling application kernels to various TTAs with a different number of datapath components and connectivity. In the best case, the cycle count is reduced to 52% when compared to a heuristic scheduler. In addition to producing shorter schedules, the number of register accesses in the compiled programs is generally notably less than those with the heuristic scheduler; in the best case, the ILP scheduler reduced the number of register file reads to 33% of the heuristic results and register file writes to 18%. On the other hand, as expected, the ILP-based scheduler uses distinctly more time to produce a schedule than the heuristic scheduler, but the compilation time is within tolerable limits for production-code generation.
Getting the Cocktail Party Started: Masking Effects in Speech Perception
Authors: Evans Samuel , McGettigan Carolyn , Agnew Zarinah K. , Rosen Stuart , Scott Sophie K. 
Published: December 2015

AbstractSpoken conversations typically take place in noisy environments, and different kinds of masking sounds place differing demands on cognitive resources. Previous studies, examining the modulation of neural activity associated with the properties of competing sounds, have shown that additional speech streams engage the superior temporal gyrus. However, the absence of a condition in which target speech was heard without additional masking made it difficult to identify brain networks specific to masking and to ascertain the extent to which competing speech was processed equivalently to target speech. In this study, we scanned young healthy adults with continuous fMRI, while they listened to stories masked by sounds that differed in their similarity to speech. We show that auditory attention and control networks are activated during attentive listening to masked speech in the absence of an overt behavioral task. We demonstrate that competing speech is processed predominantly in the left hemisphere within the same pathway as target speech but is not treated equivalently within that stream and that individuals who perform better in speech in noise tasks activate the left mid-posterior superior temporal gyrus more. Finally, we identify neural responses associated with the onset of sounds in the auditory environment; activity was found within right lateralized frontal regions consistent with a phasic alerting response. Taken together, these results provide a comprehensive account of the neural processes involved in listening in noise.
Software-based on-site estimation of fractional flow reserve using standard coronary CT angiography data
Authors: De Geer Jakob , Sandstedt Mårten , Björkholm Anders , Alfredsson Joakim , Janzon Magnus , Engvall Jan , Persson Anders 
Published: December 2015

Background The significance of a coronary stenosis can be determined by measuring the fractional flow reserve (FFR) during invasive coronary angiography. Recently, methods have been developed which claim to be able to estimate FFR using image data from standard coronary computed tomography angiography (CCTA) exams. Purpose To evaluate the accuracy of non-invasively computed fractional flow reserve (cFFR) from CCTA. Material and Methods A total of 23 vessels in 21 patients who had undergone both CCTA and invasive angiography with FFR measurement were evaluated using a cFFR software prototype. The cFFR results were compared to the invasively obtained FFR values. Correlation was calculated using Spearman’s rank correlation, and agreement using intraclass correlation coefficient (ICC). Sensitivity, specificity, accuracy, negative predictive value, and positive predictive value for significant stenosis (defined as both FFR ≤0.80 and FFR ≤0.75) were calculated. Results The mean cFFR value for the whole group was 0.81 and the corresponding mean invFFR value was 0.84. The cFFR sensitivity for significant stenosis (FFR ≤0.80/0.75) on a per-lesion basis was 0.83/0.80, specificity was 0.76/0.89, and accuracy 0.78/0.87. The positive predictive value was 0.56/0.67 and the negative predictive value was 0.93/0.94. The Spearman rank correlation coefficient was ρ = 0.77 ( P < 0.001) and ICC = 0.73 ( P < 0.001). Conclusion This particular CCTA-based cFFR software prototype allows for a rapid, non-invasive on-site evaluation of cFFR. The results are encouraging and cFFR may in the future be of help in the triage to invasive coronary angiography.
Why adjuvant chemotherapy for stage III colon cancer was not given: Reasons for non-recommendation by clinicians or patient refusal
Authors: Gilbar Peter , Lee Andrew , Pokharel Khageshwor 
Published: December 2015

Aim The aim of our study was to evaluate stage III colon cancer patients discussed at a multidisciplinary team meeting to identify reasons for clinicians not recommending adjuvant chemotherapy and reasons for patients declining recommended chemotherapy. Methods A retrospective, single institution Australian study was conducted on all surgically managed stage III colon cancer patients diagnosed at the regional cancer centre at Toowoomba Hospital between July 2010 and December 2014. Reasons why adjuvant chemotherapy was not recommended by the multidisciplinary team or following referral to a medical oncologist and patients’ reasons for refusing chemotherapy despite medical oncology recommendation were determined. Results One hundred and nine patients were suitable for evaluation. Overall, 72 (66.1%) received adjuvant chemotherapy. Chemotherapy was not recommended in 25 (23.4%) of patients, with the majority (68%) having more than one cited reason. Multiple comorbidities and advanced age were the most common reasons for non-recommendation ( p < 0.01). Age alone was not a reason for not recommending chemotherapy. Twelve (11%) patients declined offered chemotherapy. The reasons for refusal were not detailed in the majority of patient charts (63.6%). Travel distance was not a factor in accepting or refusing chemotherapy. Conclusion Discussion at a multidisciplinary team meeting facilitates the identification of patients unsuitable for adjuvant treatment. The reasons for declining offered chemotherapy need to be assessed fully to ensure that patients’ treatment preferences are balanced against the proven benefits of chemotherapy. Attendance at a regional cancer centre provides the opportunity for high standard care in the management of stage III colon cancer.
RETRACTED ARTICLE: Butein inhibits metastatic behavior in mouse melanoma cells through VEGF expression and translation-dependent signaling pathway regulation
Authors: Lai Yu-Wei , Wang Shih-Wei , Chang Chien-Hsin , Liu Shih-Chia , Chen Yu-Jen , Chi Chih-Wen , Chiu Li-Pin , Chen Shiou-Sheng , Chiu Allen W. , Chung Ching-Hu 
Published: December 2015

Abstract
Background
Melanoma is an aggressive skin cancer and a predominant cause of skin cancer-related deaths. A previous study has demonstrated the ability of butein to inhibit tumor proliferation and invasion. However, the anti-metastatic mechanisms and in vivo effects of butein have not been fully elucidated.

Methods
MTT cell viability assays were used to evaluate the antitumor effects of butein in vitro. Cytotoxic effects of butein were measured by lactate dehydrogenase assay. Anti-migratory effects of butein were evaluated by two-dimensional scratch and transwell migration assays. Signaling transduction and VEGF-releasing assays were measured by Western blotting and ELISA. We also conducted an experimental analysis of the metastatic potential of tumor cells injected into the tail vein of C57BL/6 mice.

Results
We first demonstrated the effect of butein on cell viability at non-cytotoxic concentrations (1, 3, and 10 μM). In vitro, butein was found to inhibit the migration of B16F10 cells in a concentration-dependent manner using transwell and scratch assays. Butein had a dose-dependent effect on focal adhesion kinase, Akt, and ERK phosphorylation in B16F10 cells. Butein efficiently inhibited the mTOR/p70S6K translational inhibition machinery and decreased the production of VEGF in B16F10 cells. Furthermore, the in vivo antitumor effects of butein were demonstrated using a pulmonary metastasis model.

Conclusion
The results of the present study indicate the potential utility of butein in the treatment of melanoma.
Endoscopic Dacryocystorhinostomy (DCR): A comparative study between powered and non-powered technique
Authors: Herzallah Islam , Alzuraiqi Bassam , Bawazeer Naif , Marglani Osama , Alherabi Ameen , Mohamed Sherif K. , Al-Qahtani Khalid , Al-Khatib Talal , Alghamdi Abdullah 
Published: December 2015

Background Dacrocystorhinostomy (DCR) is an operation used to treat nasolacrimal duct obstruction. Essentially there are two approaches: external and endoscopic. Several modalities are used in endoscopic DCR; all aiming to improve success rate, reduce complications, and shorten operative time. Both kerrison punch and drill are widely used in endoscopic DCR with non-conclusive knowledge about differences in operative details as well as on the outcome. The aim of this study is to compare between powered (drill) and non-powered (kerrison punch) DCR to clarify the superiority of one over the other. Methods A retrospective chart review of 59 patients who underwent endoscopic DCR procedure at our institution from June 2013 until July 2014 (34 kerrison punch and 32 powered drill). Operative details, surgical outcome and complications were compared between both groups. Results A total of 66 endoscopic DCRs were performed on 59 patients. Procedure success rate among kerrison punch group was 87.88 % vs. 90.9 % in powered drill group ( p = 0.827), while complications for both groups were statistical not significant ( p = 0.91). The mean operating time among kerrison punch group was significantly lower than in powered drill group (75 min vs. 125 min, p = 0.0001). Conclusion Kerrison punch showed significant reduction in operating time when compared to powered drill for endoscopic DCR. No statistically significant difference was found between both groups regarding procedures’ success rate and complication.
Robotic single-site excision of ovarian endometrioma
Authors: Gargiulo Antonio R. , Feltmate Colleen , Srouji Serene S. 
Published: December 2015

Abstract
Background
Conventional single-incision laparoscopic surgery has been successfully employed for treatment of ovarian endometriomas. However, this technique presents surgeons with formidable ergonomic challenges, that make its widespread adoption unlikely. Robotic assistance in single-incision laparoscopic surgery provides adequate instrument triangulation through a single fulcrum, while eliminating ergonomic challenges to the surgeon. The objective of this video is to describe a novel technique of laparoscopic excision and ablation of ovarian endometriomas with single-site robotic assistance. Footage from a single surgical case is shown in our video. The da Vinci Si surgical system with da Vinci Single-Site platform was utilized. A flexible CO2 laser fiber was employed as the main energy tool.
To describe a technique of single-incision laparoscopic excision and ablation of endometriomas with robotic assistance.
Footage from a single surgical case is shown in this video. The da Vinci Si surgical system with da Vinci Single-Site platform was utilized. A flexible CO2 laser fiber was employed as the main energy tool.

Results
Our technique achieved excellent surgical, clinical and cosmetic results, with complete excision and ablation of the endometriomas and no complications. The procedure was completed in day-surgery setting.

Conclusion
Our step-by-step video tutorial shows how the dedicated single incision laparoscopy technology for the da Vinci Si surgical system can be safely and effectively applied to the excision and ablation of ovarian endometriomas.