bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using simulation scenarios and a debriefing structure to promote feedback skills among interprofessional team members in clinical practice
Authors: Svendsen Bodil Thorsager , Petersen Lene Funck , Skjelsager Anders , Lippert Anne , Østergaard Doris 
Published: September 2024

Abstract
Background
Team reflexivity and peer feedback in daily clinical work can improve patient safety. However, teams do not always engage in reflection after patient care. A reason could be that team members may lack skills in engaging in team reflection. This study explores the use of interprofessional team-based simulations to encourage and equip teams for reflective conversations in the real-world clinical practice.

Methods
This was a prospective, explorative study of team members’ perceptions of the use of in situ simulation-based scenarios with critically ill patient cases to train team-based reflections and peer feedback. The study took place in two neurological wards. Prior to the intervention, a 1-day observation in each ward and semi-structured short interviews with physicians and nurses were conducted.

Results
A total of 94 staff members, 57 nurses, 8 nurse assistants and 29 physicians participated in the in situ simulation scenarios. All team members showed appreciation of the safe learning environment. The authors found that the simulations and the debriefing structure provided an opportunity for training of team reflexivity and feedback. The team members evaluated the simulation-based training very positively, and their initial reaction indicated that they found peer feedback useful for the individual and the team. This approach allowed them to reflect on their own clinical practice.

Conclusion
The simulation-based training scenarios and the debriefing structure promoted team members’ team reflexivity and peer feedback skills. The method is feasible and could be used in other specialties and situations.
The team members’ reactions to feedback were positive, and based on their reflections, there is a potential to increase both individual and team skills as well as improve patient treatment.
Risk factors for hypoechoic carotid plaque in healthy physical-examination population
Authors: Fu Meng , Fan Yani , Wang Jianhua , Chen Feifei , Cui Ying , Lu Yadan , Zhang Binbin , Zhang Bing , Chen Lili 
Published: September 2024

Abstract
Background
We studied the characteristics of carotid ultrasound plaque in a healthy physical-examination population and analyzed the risk factors for hypoechoic carotid plaque for early control and prevention of stroke.

Results
A total of 1333 healthy physical-examination individuals were included in this study, including 457 females and 876 males. According to the results of carotid artery ultrasound, they were divided into hyperechoic carotid plaque (n = 940) and hypoechoic carotid plaque (n = 393). Multivariate logistic analysis showed that male, alcohol consumption, and low-density lipoprotein were risk factors for hypoechoic carotid plaque. SPSS 25.0 software was used to draw the receive operating characteristic curve and calculate the prediction probability of the risk factor indicators obtained by the multifactor model. The area under the curve was also calculated to be 0.623 (95% CI = 0.591–0.655).

Conclusion
Male, alcohol consumption, and low-density lipoprotein are risk factors for hypoechoic carotid plaque in a healthy physical-examination population.
In situ observation of catalyst nanoparticle sintering resistance on oxide supports via gas phase transmission electron microscopy
Authors: Kim Wonjun , Kim Kangsik , Kim Jaejin , Lee Zonghoon 
Published: September 2024

AbstractOxide-supported metal catalysts are essential components in industrial processes for catalytic conversion. However, the performance of these catalysts is often compromised in high temperature reaction environments due to sintering effects. Currently, a number of studies are underway with the objective of improving the metal support interaction (MSI) effect in order to enhance sintering resistance by surface modification of the oxide support, including the formation of inhomogeneous defects on the oxide support, the addition of a rare earth element, the use of different facets, encapsulation, and other techniques. The recent developments in in situ gas phase transmission electron microscopy (TEM) have enabled direct observation of the sintering process of NPs in real time. This capability further allows to verify the efficacy of the methods used to tailor the support surface and contributes effectively to improving sintering resistance. Here, we review a few selected studies on how in situ gas phase TEM has been used to prevent the sintering of catalyst NPs on oxide supports.
Equivalence and test–retest reliability of Tulu sentence lists for measuring speech recognition threshold in noise among individuals with sensorineural hearing loss
Authors: Miranda Arolin Blossom , Kalaiah Mohan Kumar , Shastri Usha 
Published: September 2024

Abstract
Background
The difficulty in understanding speech becomes worse in the presence of background noise for individuals with sensorineural hearing loss. Speech-in-noise tests help to assess this difficulty. Previously, the Tulu sentence lists have been assessed for their equivalency to measure speech recognition threshold in noise among individuals with normal hearing. The present study aimed to determine the equivalence and test–retest reliability of Tulu sentence lists for measuring speech recognition threshold in noise among individuals with sensorineural hearing loss.

Results
The SNR-50 was measured for 13 sentence lists in 20 Tulu-speaking individuals with mild to moderate sensorineural hearing loss. Retesting was done by administering all lists to eight participants after an average of 25.25 days (SD = 19.44). Friedman test was administered to check for the list equivalency. Intraclass correlation coefficient was measured to assess test–retest reliability. A regression analysis was performed to understand the influence of pure-tone average on SNR-50. A Kruskal–Wallis test was administered to check the statistical significance of the SNR-50 obtained across different configurations and degrees of hearing loss. Nine of the 13 Tulu sentence lists (lists 2, 4, 5, 6, 9, 10, 11, 12, and 13) were equivalent in individuals with sensorineural hearing loss. The mean SNR-50 for these nine lists was 1.13 dB (SD = 2.04 dB). The test–retest reliability was moderate (ICC = 0.727). The regression analysis showed that a pure-tone average accounted for 24.7% of the variance in SNR-50 data (p = 0.026). Individuals with mild to moderate hearing loss obtained the worst SNR-50, followed by mild and high-frequency hearing loss.

Conclusion
Nine Tulu sentence lists are equivalent and reliable and can be used to measure speech recognition threshold in noise among individuals with sensorineural hearing loss who are Tulu speakers.
Effect of advancing age on event-related potentials (P300) measures
Authors: Shubhadarshan Archisman , Gaiwale Uneza 
Published: September 2024

Abstract

Background
Aging has been defined as a persistent deterioration in the age-specific fitness components of an organism, attributed to internal physiological degeneration. Cognitive abilities, encompassing attention, memory, executive cognitive functions, language, and visuospatial capacities, are distinctive domains affected by aging. Numerous studies have documented measurable effects on these cognitive domains, indicating a discernible decline in their functionality with advancing age. Cognitive impairment often unfolds insidiously, remaining clinically silent for extended periods. Age, as a critical factor, exerts a notable influence on P300 measures.

Result
Spearman rank correlation was calculated between age and P300 measures. In group 1A (age range of 10–20 years), we found a strong positive correlation between age and amplitude of P300 (r = 0.96, p < 0.001), while a weak correlation was found between latency and age. In group IB (age range: 21–40 years), a moderate negative correlation (r =  − 0.43, p < 0.05) was found between age and amplitude of P300, while a strong positive correlation (r = 0.87, p < 0.001) was obtained between age and latency. In group 2A (age: 41–60 years), it was found that amplitude has a strong negative correlation (r =  − 0.97, p < 0.001) with age, while latency has a strong positive correlation (r = 0.89, p < 0.001). In group 2B (age: 61–80 years), it was found that amplitude has a strong negative correlation (r =  − 0.93, p < 0.001) with age, while latency has a strong positive correlation (r = 0.95, p < 0.001).

Conclusion
In this study, it is concluded that amplitude of P300 decreases and latency increases with increasing age.
The effect of displacement loading rate on dynamic mechanical characteristics of fault stick-slip under constant normal stiffness conditions
Authors: Zhang Chuanqing , Zhang Luosong , Tao Zhigang , Xie Qiming , Zhou Aoge , Cui Guojian 
Published: September 2024

The role of the displacement loading rate in fault activation and evolution is of utmost importance, yet most existing studies have primarily focused on its effect under constant normal load (CNL) conditions. However, in reality, the rock mass surrounding the earthquake source at the deep part of the fault provides normal stiffness conditions. Therefore, the influence of the displacement loading rate on the dynamic mechanical characteristics of fault stick-slip under constant normal stiffness (CNS) conditions remains uncertain. To bridge this research gap, we conduct an experimental investigation on simulated faults in granite under CNS conditions. Our analysis focus on the influence of the displacement loading rate on the spatial and temporal evolution of local stresses along the fault and the size of the fault nucleation zone. The findings reveal the following. Under the CNS condition, the equivalent shear stress is larger compared with the CNL condition, whereas the shear stress drop is smaller. The recovery of normal stress under CNS conditions depends more on the displacement loading rate. The nucleation location of the fault is influenced by the normal boundary conditions, with a larger nucleation zone observed in the CNS condition than in the CNL condition. In the early stage of friction, the local stress and stress drop of the fault exhibit a positive correlation with the displacement loading rate, whereas in the later stage, they display a negative correlation. Moreover, at the same location, the order of local stress drop rates for the fault is [Formula: see text] > [Formula: see text] > [Formula: see text], where [Formula: see text] represents the local normal stress drop rate, [Formula: see text] represents the local shear stress drop rate, and [Formula: see text] represents the local friction coefficient drop rate. These research results contribute to a further understanding of the deep fault-slip mechanical behavior.
Criminal intent and psychiatric evidence
Authors: Hallett Nicholas , Odutola Akinkunmi , Storey Tony , Wortley Natalie 
Published: September 2024

SUMMARYAlthough forensic psychiatrists are often asked to comment on a defendant's capacity to form the necessary mens rea for their alleged offence, little has been written on how mental disorders map onto legal concepts of mens rea, particularly those of intention. In this article we explore legal concepts of mens rea and the relevance of mental disorders and alcohol intoxication. We briefly consider philosophical approaches to intentional action and a variety of common mental disorders. We conclude that despite the presence of significant psychopathology it is rare for mental disorders to cause a defendant to lack the ability to form mens rea. Experts should therefore be cautious about coming to the conclusion that they do lead to a lack of capacity to form mens rea and should make clear the limits of their expertise, given the difficulty of translating clinical mental states into legal concepts of liability.
A community-based treatment and rehabilitation pathway for people with mental disorders recently convicted of an offence
Authors: Arsuffi Lara , Ozcelik Kerry , Bingham Clare , Taylor Pamela J. , French Mignon 
Published: September 2024

SummaryPeople with mental disorders can receive treatment in the community. Some, however, fall out of services and into the criminal justice system, running the risk of imprisonment and a deteriorating mental health cycle. This editorial describes Mental Health Treatment Requirements (MHTRs), that is court-imposed sentences that enable people in the UK to access treatment in the community and divert them from short custodial sentences. MHTRs have proven successful for people with primary care mental health needs. It remains difficult to secure these sentences for people with secondary care mental health needs. Three new ‘proof of concept’ sites for secondary care MHTRs may help understand barriers and find solutions.
Clozapine, relapse, and adverse events: a 10-year electronic cohort study in Canada
Authors: Balbuena Lloyd , Halayka Shawn , Lee Andrew , Ahmed A.G. , Hinz Tamara , Kolla Nathan , Pylypow Jenna 
Published: September 2024

BackgroundClozapine is the most effective medication for treatment-resistant psychoses, but the balance of benefits and risks is understudied in real-world settings.AimsTo examine the relative re-hospitalisation rates for mental health relapse and adverse events associated with clozapine and other antipsychotics in adult and child/youth cohorts.MethodData were obtained from the Canadian Institute of Health Information for adults (n = 45 616) and children/youth (n = 1476) initially hospitalised for mental health conditions in British Columbia, Manitoba and Saskatchewan from 2008 to 2018. Patient demographics and hospitalisations were linked with antipsychotic prescriptions dispensed following the initial visit. Recurrent events survival analysis for relapse and adverse events were created and compared between clozapine and other antipsychotics.ResultsIn adults, clozapine was associated with a 14% lower relapse rate versus other drugs (adjusted hazard ratio: 0.86, 95% CI: 0.83–0.90) over the 10-year follow-up. In the first 21 months, the relapse rate was higher for clozapine but then reversed. Over 1000 person-months, clozapine-treated adults could be expected to have 38 relapse hospitalisations compared with 45 for other drugs. In children/youth, clozapine had a 38% lower relapse rate compared with other antipsychotic medications (adjusted hazard ratio: 0.62, 95% CI: 0.49–0.78) over the follow-up period. This equates to 29 hospitalisations for clozapine and 48 for other drugs over 1000 person-months. In adults, clozapine had a higher risk for adverse events (hazard ratio: 1.34, 95% CI: 1.18–1.54) over the entire follow-up compared with other antipsychotics. This equates to 1.77 and 1.30 hospitalisations over 1000 person-months for clozapine and other drugs, respectively.ConclusionsClozapine was associated with lower relapse overall, but this was accompanied by higher adverse events for adults. For children/youth, clozapine was associated with lower relapse all throughout and had no difference in adverse events compared with other antipsychotics.
Atezolizumab Combined With Platinum and Maintenance Niraparib for Recurrent Ovarian Cancer With a Platinum-Free Interval >6 Months: ENGOT-OV41/GEICO 69-O/ANITA Phase III Trial
Authors: González-Martín Antonio , Rubio María Jesús , Heitz Florian , Depont Christensen René , Colombo Nicoletta , Van Gorp Toon , Romeo Margarita , Ray-Coquard Isabelle , Gaba Lydia , Leary Alexandra , De Sande Luis Miguel , Lebreton Coriolan , Redondo Andrés , Fabbro Michel , Barretina Ginesta Maria-Pilar , Follana Philippe , Pérez-Fidalgo J. Alejandro , Rodrigues Manuel , Santaballa Ana , Sabatier Renaud , Bermejo-Pérez Maria José , Lotz Jean-Pierre , Pardo Beatriz , Marquina Gloria , Sánchez-Lorenzo Luisa , Quindós María , Estévez-García Purificación , Guerra Alía Eva , Manso Luis , Casado Victoria , Kommoss Stefan , Tognon Germana , Henry Stéphanie , Bruchim Ilan , Oaknin Ana , Selle Frédéric 
Published: September 2024

PURPOSE
To evaluate atezolizumab combined with platinum-based chemotherapy (CT) followed by maintenance niraparib for late-relapsing recurrent ovarian cancer.

METHODS

The multicenter placebo-controlled double-blind randomized phase III ENGOT-OV41/GEICO 69-O/ANITA trial (ClinicalTrials.gov identifier:
NCT03598270
) enrolled patients with measurable high-grade serous, endometrioid, or undifferentiated recurrent ovarian cancer who had received one or two previous CT lines (most recent including platinum) and had a treatment-free interval since last platinum (TFIp) of >6 months. Patients were stratified by investigator-selected carboplatin doublet, TFIp,
BRCA
status, and PD-L1 status in de novo biopsy and randomly assigned 1:1 to receive either atezolizumab or placebo throughout standard therapy comprising six cycles of a carboplatin doublet followed (in patients with response/stable disease) by maintenance niraparib until progression. The primary end point was investigator-assessed progression-free survival (PFS) per RECIST v1.1.

RESULTS

Between November 2018 and January 2022, 417 patients were randomly assigned (15%
BRCA-
mutated, 36% PD-L1–positive, 66% TFIp >12 months, 11% previous poly [ADP-ribose] polymerase inhibitor after frontline CT, and 53% previous bevacizumab). Median follow-up was 28.6 months (95% CI, 26.6 to 30.5 months). Atezolizumab did not significantly improve PFS (hazard ratio, 0.89 [95% CI, 0.71 to 1.10];
P
= .28). Median PFS was 11.2 months (95% CI, 10.1 to 12.1 months) with atezolizumab versus 10.1 months (95% CI, 9.2 to 11.2 months) with standard therapy. Subgroup analyses generally showed consistent results, including analyses by PD-L1 status. The objective response rate (ORR) was 45% (95% CI, 39 to 52) with atezolizumab and 43% (95% CI, 36 to 49) with standard therapy. The safety profile was as expected from previous experience of these drugs.

CONCLUSION
Combining atezolizumab with CT and maintenance niraparib for late-relapsing recurrent ovarian cancer did not significantly improve PFS or the ORR.
A Potential Role for Nivolumab in the Treatment of Fibrous Dysplasia-Related Pain
Authors: Jay Mohammad , Hawco Cassandra , Clemens Kristin K , Van Uum Stan 
Published: September 2024

Abstract
Fibrous dysplasia (FD) is a chronic and progressive disorder of bone growth because of decreased osteoblast formation and osteoclast overactivity. Its main symptoms include pain, fracture, and irregular bone growth. Bisphosphonates are the mainstay of therapy for FD with a primary goal of pain relief. A 50-year-old woman presented to ophthalmology in March 2011 with intermittent proptosis, vertical diplopia, and orbital pain. A computed tomography scan of the head revealed a skull base lesion, which was confirmed to be fibrous dysplasia on bone biopsy. Because of significant headache, she was treated with IV pamidronate monthly starting November 2011, which led to pain reduction. Repeated attempts to decrease the frequency of pamidronate were unsuccessful because of breakthrough pain. Oral alendronate and risedronate did not control her symptoms. She remained on risedronate however because of its convenience. In August 2021, she was diagnosed with metastatic melanoma and started nivolumab. Her headache completely resolved for the first time in 10 years. Although nivolumab, a programmed death-1 blocker, has been used in the treatment of bone malignancy, it has not been previously studied in FD. By suppressing RANK ligand-related osteoclastogenesis, nivolumab decreases cancer-associated bone pain. Our case suggests a potential role for nivolumab in treating FD-associated pain.
Virginia Woolf, David Jones, and the Parenthetical Space of War
Authors: Ben-Tovim Ron 
Published: September 2024

Abstract
Home and war seem to be spaces set apart, one defined by the rules and order of society and the other by the absolute, order-undoing destruction of battle. Yet for those families who endure war even from afar, and for those who return from war, its violence continues to fester unseen. Through a reading of Virginia Woolf’s To the Lighthouse and David Jones’s World War I epic In Parenthesis, this essay interrogates that duality through the way in which the parenthetical, repressed violence of World War I steals into the home, threatening to undermine its foundations. These works, each with its emphasis on either home or front, present a complex view of that war as well as its dark, lingering influence. Ranging from the home to the trenches, Woolf and Jones unfurl a scene of violence, composed of countless parentheticals, that presents the Great War not as a space apart but as an invasive event.
The Production of Wounded Attachment
Authors: Köstem Burç 
Published: September 2024

Abstract
This article locates itself in the aftermath of the 2016 coup attempt in Turkey to study the cultural production of reactionary sentiment. Placing Wendy Brown's concept of “wounded attachment” in conversation with materialist and anticolonial theorizations of indignation in Turkey and beyond, the article explores the production of a reactionary mood that traverses affective, economic, technological, and cultural dynamics. In order to do so, it focuses on an intriguing example of wounded attachment in the post-2016 period: the sense of concern and anxiety that has formed around public performances of the ezan (the Islamic call to prayer). The article argues that feelings of indignation, victimhood, and revenge are crucial to Turkish politics, as their production lies at the intersection of specific memories of injury and the material foundations of contemporary capitalism in Turkey.
Archives beyond the Human
Authors: Oliver Catherine 
Published: September 2024

Abstract
This article reflects on what it might mean to think about archives “beyond” the human, specifically in relation to animals and their archives. Interdisciplinary and disciplinary “animal turns” have brought animals into social science and humanities spaces—as both subjects and collaborators. In archival research and studies, encounters with animals, and more broadly nonhumans, both complicate and extend contemporary debates: on how we research in the archives, on ethics and politics, and even on what constitutes an archive. Drawing from three different case studies from its author's research with historical animals—in a traditional archive, in the digital archive, and in a speculative archive—the article reflects on some of these contemporary debates to ask how we might meaningfully extend archives beyond the human.
Sustainable Data Rivers? Rebalancing the Data Ecosystem That Underlies Generative AI
Authors: Delacroix Sylvie 
Published: September 2024

Abstract
The salient concern, today, is not whether copyright law will “allow robots to learn.” The pressing question is whether the exploitation of the data ecosystem that has made generative AI possible can be made socially sustainable. Just as the human right to water is only possible if reasonable use and reciprocity constraints are imposed on the economic exploitation of rivers, so is the fundamental right to access culture, learn, and build upon it. To restore this right to its proper place within the balancing act IP law is supposed to enable demands fundamental legal reform. This article explores the merits of reconstructing copyright as a permitted privilege (rather than property right). It also highlights the extent to which, for such reform to bear fruit and contribute to a socially sustainable data ecosystem, it needs to be supported by bottom-up participatory infrastructure.