bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐Method Structural Investigation of the Schneiderberg–Baalberge Burial Mound (Saxony‐Anhalt, Germany) Including Seismic Full‐Waveform Inversion (FWI)
Authors: Zolchow Manuel , Köhn Daniel , Wilken Dennis , Erkul Ercan , Dreibrodt Stefan , Pickartz Natalie , Corradini Erica , Müller Johannes , Rabbel Wolfgang 
Published: October 2024

ABSTRACTThe construction history and subsequent usage of burial mounds are an important testimony for socio‐economic transformation in prehistoric societies. The Baalberge–Schneiderberg burial mound, subject of the presented study, falls in this category as it is considered as an important monument that indicates the emergence of early social stratification during the Chalcolithic period in central Europe. This hypothesis relies on the chronological development of the burial mound, which is not fully understood until now. Therefore, a reconstruction of the complex stratigraphy of the burial mound including construction phases and later alterations is highly relevant for archaeological research, but the required excavations would be onerous and inconsistent with preservation efforts. In this paper, we demonstrate that non‐invasive geophysical prospection, especially seismic sounding with shear and Love waves, is suitable to obtain the required stratigraphic information, if seismic full waveform inversion (FWI) and reflection imaging are applied. Complementary information on the preservation state of the mound is obtained through Electrical Resistivity Tomography (ERT) and Electromagnetic Induction (EMI) measurements. To support the seismic and geoelectric results, we utilize Dynamic Testing (DynP), geoarchaeological corings, 14C‐Dating and archaeological records. Our investigations reveal two construction phases of the Baalberge–Schneiderberg mound. The 14C‐Dating yields dates for the older burial mound that are contemporary to the Chalcolithic Baalberge group (4000–3400 bc). During the Early Bronze Age (EBA), the mound was enlarged to its final size by people of the Aunjetitz/Únětice society (2300–1600 bc). However, both seismic and geoelectric depth sections show an extensive disturbance of the original stratigraphy due to former excavations. For this reason, the exact shape of the older burial mound cannot be determined exactly. Based on our data, we estimate that its height was below 2 m. In consequence, the original Baalberge burial mound was less monumental as until now assumed, which potentially prompting a revision of its significance as indicator for social differentiation.
Investigation of Electrolyte Salts in Non‐Flammable Triethyl Phosphate for Sodium‐Ion Batteries
Authors: Van Ekeren Wessel W. A. , Dettmann Lasse , Tesfamhret Yonas , Naylor Andrew J. , Younesi Reza 
Published: October 2024

AbstractFive different electrolyte salts, namely NaBF4, NaClO4, NaDFOB, NaFSI and NaPF6, were evaluated in non‐flammable triethyl phosphate (TEP) based electrolyte solutions in sodium‐ion full‐cells using high‐mass loading Prussian white and hard carbon electrodes. Their impact on the viscosity, ionic conductivity and solvation structure was analyzed, revealing that NaFSI‐based electrolytes exhibited a stronger interaction with TEP and less ion‐pairing than the other salts, resulting in the highest ionic conductivity at a concentration of 0.8 m (mol/kg). Galvanostatic cycling experiments showed that none of the electrolyte salts dissolved in TEP forms an efficient passivation layer. However, adding 1 wt.% vinylene carbonate (VC) significantly improved cycling performance for the cells with NaBF4, NaDFOB or NaFSI, but not with NaClO4 or NaPF6. Additionally, NaFSI in TEP with 1 wt.% VC electrolyte solution showed minimal gas evolution during the formation cycling (<8 mbar). In a 1 Ah multilayer pouch cell, 0.8 m NaFSI in TEP with 1 wt.% VC showed promising results with 88 % capacity retention after 200 cycles. X‐ray photoelectron spectroscopy analysis indicated that the addition of VC results in the formation of a thin SEI and minimized TEP decomposition, particularly for 0.8 m NaFSI TEP with 1 wt.% VC. This study lays the groundwork for safer liquid electrolytes and integrating them into near‐to‐commercial cell setups.
Sustainable supply chain, dynamic capabilities, eco‐innovation, and environmental performance in an emerging economy
Authors: Siddiqi Roheel Ahmed , Codini Anna Paola , Ishaq Muhammad Ishtiaq , Jamali Dima Rachid , Raza Ali 
Published: October 2024

AbstractOrganizations can reduce costs and achieve better performance by utilizing supply chain management. However, they face enormous challenges in building eco‐friendly supply chains for harmony with nature, especially in emerging economies. Therefore, the current study seeks to determine the direct impact of sustainable supply chain management practices (SSCM) on environmental performance in Pakistani industries. The mediating role of eco‐innovation and sustainable, dynamic capabilities and the moderating role of institutional support were also tested. The data from 309 key informants were collected using a multisource approach and analyzed via structural equation modeling. The results indicated that SSCM and eco‐innovation positively impact environmental performance, but dynamic capabilities have negatively influenced environmental performance. Additionally, dynamic capabilities and eco‐innovation mediate the relationship between SSCM and eco‐innovation, and institutional support moderates the relationships positively. These results will enhance the theoretical base in supply chain management literature by exploring the role of SSCM in environmental performance. For practical implications, these results help managers in using institutional support to achieve environmental goals.
Comparison of Three Different Extraction Methods on Schizonepeta tenuifolia (Benth.) Briq Essential Oil: Chemical Constituents and in Vitro and in Silico Biological Activities
Authors: He Linhong , Zhang Lijuan , Bai Xi 
Published: October 2024

AbstractThis study evaluated the effects of three extraction methods, hydrodistillation (HD), steam distillation (SD), and lipophilic solvent extraction (LSE), on the yield, chemical composition, and in vitro/in silico biological activities of Schizonepeta tenuifolia (Benth.) Briq essential oil (STEO). The highest yield of STEO was obtained by HD (0.750±0.040 %), followed by SD (0.440±0.020 %) and LSE (0.350±0.030 %). Although their contents varied, menthone and pulegone predominated in HDEO, SDEO, and LSEO. HDEO displayed the strongest antioxidant ability, with a 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) IC50 value of 14.164±0.090 mg/mL and (2,2′‐azino‐bis (3ethylbenzothiazoline‐6‐sulfonic acid)) (ABTS) value of 0.326±0.023 mg/mL. SDEO demonstrated the highest antimicrobial activity against Staphylococcus aureus and Escherichia coli and HDEO the highest potent anti‐inflammatory activity. The molecular docking of menthone and pulegone demonstrated strong binding to inflammatory targets, including prostaglandin‐endoperoxide synthase 1 (PTGS1) and 2 (PTGS2) and tumor necrosis factor alpha (TNF‐α). In short, the extraction method significantly affected the yield, composition, and biological activity of STEO.
Covalent Modification of Protein by Chemical Probe in Living Cells for Structural and Interaction Studies
Authors: Zheng Zhenxiang , Cheng Yuyu , Li Pengfei , Heng Tan Chris Soon 
Published: October 2024

AbstractCellular activities are predominantly carried out by proteins that can dynamically adopt different structural conformations and differentially interact with other biomolecules according to cellular needs. Chemical probes are small molecules used to selectively interact and modulate the activities of specific proteins to study their functions such as the validation of potential drug targets. The remarkable performance of AlphaFold algorithms in the prediction of protein structures has pivoted interest toward elucidating the intracellular dynamics of protein structural conformation where covalent modification of proteins by chemical probes could be used to shed light upon. However, due to the barrier to entry by cell membrane and the general unfavorable reactive conditions of the intracellular environment, most studies using reactive chemical probes are still conducted on purified proteins and cell lysates. Nevertheless, recent progresses have been made in designing chemical probes with improved membrane permeability, stability and reactivity. This paper surveys the literature on recent advancements in membrane‐permeable chemical probes and their applications with protein mass spectrometry for the intracellular studies of protein structural conformations and biomolecular interactions.
Changes of gluten protein composition during sourdough fermentation in rye flour
Authors: Muskovics Gabriella , Farkas Alexandra , Bugyi Zsuzsanna , Tömösközi Sandor 
Published: October 2024

AbstractBackground and ObjectivesCeliac disease (CD) is an immune‐mediated condition triggered by gluten consumption. Although more studies stated that gluten proteins are partially degrading during sourdough fermentation, it is still unclear whether the CD toxic epitopes are affected. Our aim was to examine the effect of controlled sourdough fermentation on the gluten content and composition with different sourdough starters in rye flour.FindingsDespite significant changes in protein size distribution and a decrease in secalin types confirmed by high‐performance liquid chromatography methods, the enzyme‐linked immunosorbent assay results showed increased gluten content after fermentation. The incomplete degradation of gluten and the potential resistance of celiac toxic epitopes may explain our results. As part of the R5 antibody binding, epitopes are supposed to be unavailable in the native form of secalins; they might be released and become accessible in the smaller protein fragments.ConclusionsIn comparison of the effect of different starter cultures, the results show that the different microbiological composition of the sourdough samples might be the reason for the differences in the protein degradation.Significance and NoveltyResults highlight the importance of a deeper investigation of the effects of gluten protein degradation on CD toxicity and the standardization of the fermentation process.
Electrochemical Formation and Removal of Homogeneous Cu Catalysts
Authors: Pirgach Dmitry A. , Miloserdov Fedor M. , van Es Daan S. , Bruijnincx Pieter C. A. , Bitter Johannes H. 
Published: October 2024

AbstractTransition metal ions and their complexes play a crucial role in homogeneous catalysis. These catalysts are pivotal for the production of, for example, fine chemicals and pharmaceuticals. Nevertheless, because of the homogeneous nature of these catalysts, their extraction and removal from the crude reaction mixture is cumbersome. Here, we propose an alternative approach where metal‐based homogeneous catalysts are generated electrochemically from a metallic anode (Cu), followed by their use without current, and finally again electrochemically deposited on the cathode. The generated Cu ions were used as catalysts in three different reactions of lauroyl peroxide: one ligand‐free (coupling with dienes), one without ligand but with a heteroatom containing substrate (coupling with toluidine and styrene) and one in the presence of 1,10‐phen as ligand (coupling with indazole). In the first two cases, performance of the electrochemically generated catalysts was similar to those reported in literature for classically prepared homogeneous catalysts, whereas in the last case a new reaction was observed. After reaction, the homogeneous copper catalyst could be efficiently removed electrochemically: 99% of the copper could be removed for the ligand‐free reaction, 97% for the amine coupling, whereas 89% of copper could be removed for the reaction containing N‐heterocycle and 1,10‐phenanthroline.
Geochemical Interaction and Bioavailability of Zinc in Soil Under Long‐Term Integrated Nutrient Management in Pearl Millet–Wheat System
Authors: Saroha Diksha , Yadav Narender , Mukhopadhyay Raj , Raj Dev , Sharma Manoj Kumar , Kumar Rohtas , Duhan Anil 
Published: October 2024

ABSTRACTThe degree and severity of zinc (Zn) deficiency in soil reduced the agricultural yield and quality, thus encouraging malnutrition in humans worldwide. The study was hypothesized to increase the bioavailability and release of Zn in soil and Zn biofortification in wheat grains under integrated nutrient management (INM). The long‐term (54 years) experiment laid out in a split‐plot design comprising single (W) and dual (PW) applications of farmyard manure (FYM) (0, 5, 10, and 15 Mg ha−1) and nitrogen (0, 60, and 120 kg ha−1) was studied to understand the distribution of different Zn fractions in soil and their relationship to wheat grain yield and Zn uptake. A laboratory incubation study was performed on surface soils to evaluate the release kinetics of native Zn at field capacity. The different fractions of Zn in soil increased with increasing frequency and levels of FYM application. Residual Zn constituted the maximum proportion (89.03%) of total soil Zn. A high positive correlation (p < 0.01) of diethylenetriaminepentaacetic acid (DTPA)‐extractable Zn and total grain Zn content were observed with different Zn fractions. The release kinetics of native soil Zn increased up to 10 days and became almost constant, indicating the establishment of chemical equilibria between the soil solid and solution phase. Thus, long‐term INM ensured higher wheat production (6.08 Mg ha−1) and Zn biofortification (38.95 mg kg−1) to combat Zn malnutrition and achieve the United Nations’ sustainable development goals on “zero hunger” and “good health and well‐being.”
A Dual Action Platinum(IV) Complex with Self‐assembly Property Inhibits Prostate Cancer through Mitochondrial Stress Pathway
Authors: Nafees Muhammad , Hanif Muhammad , Muhammad Asif Khan Raja , Faiz Faisal , Yang Piaoping 
Published: October 2024

AbstractPlatinum(IV) prodrugs are highly promising anticancer agents because they can selectively target tumors and minimize the adverse effects associated with their PtII congeners. In this study, we synthesized dual action PtIV complexes by linking oxoplatin with lithocholic acid. The synthesized compounds, designated as PL‐I, PL‐II, and PL‐III, can spontaneously self‐assemble in water, resulting in the formation of spherical shape nanoparticles. Among the developed complexes, PL‐III appeared to be the most potent compound against all the tested cancer cell lines, with 10 fold higher cytotoxicity compared to cisplatin in PC3 cells. The complex arrests the cell cycle in the S and G2 phases and induces DNA damage. Additional mechanistic investigations demonstrate that PL‐III predominantly localizes within the mitochondria and cytoplasm. Consequently, PL‐III disrupts mitochondrial membrane potential, increases ROS production, and perturbs mitochondrial bioenergetics in PC3 cells. The complex induces apoptosis through the mitochondrial pathway by upregulating pro‐apoptotic protein expression and downregulating anti‐apoptotic protein expression from the BCl‐2 protein family. These results demonstrate that higher cellular uptake and reduction of PL‐III by biological reductants in PC3 cells resulted in a synergistic effect of lithocholic acid and cisplatin, which can be easily observed due to its unique cytotoxic mechanism. This further underscores the significance of dual‐action PtIV complexes in enhancing the efficacy of cancer therapy.
Self‐rated health is an independent predictor of subsequent late mortality after blood or marrow transplantation: A Blood or Marrow Transplant Survivor Study report
Authors: Balas Nora , Richman Joshua , Landier Wendy , Shrestha Sadeep , Bruxvoort Katia J. , Hageman Lindsey , Meng Qingrui , Ross Elizabeth , Bosworth Alysia , Te Hok Sreng , Wong F. Lennie , Bhatia Ravi , Forman Stephen J. , Armenian Saro H. , Weisdorf Daniel J. , Bhatia Smita 
Published: October 2024

AbstractBackgroundThe prevalence of suboptimal self‐rated health (SRH) and its association with subsequent all‐cause and cause‐specific mortality after blood or marrow transplantation (BMT) were examined.MethodsStudy participants were drawn from the multicenter Blood or Marrow Transplant Survivor Study, and included patients who were transplanted between 1974 and 2014 and had survived ≥2 years after BMT. Participants (aged ≥18 years) completed a survey at a median of 9 years from BMT, and were followed for a median of 5.6 years after survey completion. Survivors provided information on sociodemographic factors, chronic health conditions, health behaviors, and SRH (a single‐item measure rated as excellent, very good, good, fair, or poor; excellent, very good, and good SRH were classified as good SRH, and fair and poor were classified as suboptimal SRH). The National Death Index Plus and Accurint databases and medical records provided vital status through December 2021.ResultsOf 3739 participants, 784 died after survey completion (21%). Overall, 879 BMT survivors (23.5%) reported suboptimal SRH. Pain, low socioeconomic status, psychological distress, lack of exercise, severe/life‐threatening chronic health conditions, post‐BMT relapse, obesity, smoking, and male sex were associated with suboptimal SRH. BMT survivors who reported suboptimal SRH had a 1.9‐fold increased risk of all‐cause mortality (95% confidence interval [CI], 1.6–2.3), 1.8‐fold increased risk of recurrence‐related mortality (95% CI, 1.4–2.5), and 1.9‐fold increased risk of non–recurrence‐related mortality (95% CI, 1.4–2.4) compared to those who reported good SRH.ConclusionsThis single‐item measure could help identify vulnerable subpopulations who could benefit from interventions to mitigate the risk for subsequent mortality.
Fish That Fish for Fish—A Peculiar Location of “Fishing Motoneurons” in the Striated Frogfish Antennarius striatus
Authors: Hagio Hanako , Nishino Hirotaka , Miyake Kenta , Sato Nene , Sawada Kei , Nakayama Tomoya , Yamamoto Naoyuki 
Published: October 2024

ABSTRACTIn lophiform teleosts, the first dorsal fin has evolved as a specialized structure called the “illicium” equipped with the esca, which is a modified skin flap used to attract small fish for predation. The motor control system of the illicium, however, remained unknown. The present study investigated the innervation of muscles for the illicium and morphology of motoneurons innervating them in the striated frogfish Antennarius striatus. We found that the dorsal ramus of occipital nerve innervates the muscles. Motoneurons for the illicium are present in the dorsolateral zone of ventral horn at the medullo‐spinal boundary level, forming a cluster somewhat distinct from other motoneurons of the ventral horn. Motoneurons for the second to fourth dorsal fins and pectoral fin were located in the ventrolateral and ventromedial zones of ventral horn, respectively, whereas those of the dorsal trunk muscle in the dorsomedial zone of ventral horn. Motoneurons for the first dorsal spine of white‐spotted pygmy filefish were also investigated for species comparison and were found to locate in the ventrolateral zone of ventral horn, similarly to the motoneurons for the second to fourth dorsal fins of the frogfish. These results suggest that motoneurons for the illicium have become segregated from other motoneurons to be situated in an unusual dorsal position for a motoneuron pool of a dorsal fin, in concert with the evolution of specialized “fishing behavior” performed by the illicium.
Neuromuscular Transmission in a Biological Context
Authors: Slater Clarke R. 
Published: October 2024

AbstractNeuromuscular transmission is the process by which motor neurons activate muscle contraction and thus plays an essential role in generating the purposeful body movements that aid survival. While many features of this process are common throughout the Animal Kingdom, such as the release of transmitter in multimolecular “quanta,” and the response to it by opening ligand‐gated postsynaptic ion channels, there is also much diversity between and within species. Much of this diversity is associated with specialization for either slow, sustained movements such as maintain posture or fast but brief movements used during escape or prey capture. In invertebrates, with hydrostatic and exoskeletons, most motor neurons evoke graded depolarizations of the muscle which cause graded muscle contractions. By contrast, vertebrate motor neurons trigger action potentials in the muscle fibers which give rise to all‐or‐none contractions. The properties of neuromuscular transmission, in particular the intensity and persistence of transmitter release, reflect these differences. Neuromuscular transmission varies both between and within individual animals, which often have distinct tonic and phasic subsystems. Adaptive plasticity of neuromuscular transmission, on a range of time scales, occurs in many species. This article describes the main steps in neuromuscular transmission and how they vary in a number of “model” species, includingC. elegans,Drosophila, zebrafish, mice, and humans. © 2024 American Physiological Society.Compr Physiol14:5641‐5702, 2024.
Maternal Microvascular Dysfunction During and After Preeclamptic Pregnancy
Authors: Schwartz Kelsey S. , Stanhewicz Anna E. 
Published: October 2024

Abstract

Preeclampsia, a pregnancy disorder characterized by
de novo
hypertension and maternal multisystem organ dysfunction, is the leading cause of maternal mortality worldwide and is associated with a fourfold greater risk of cardiovascular disease throughout the lifespan. Current understanding of the etiology of preeclampsia remains unclear, due in part to the varying phenotypical presentations of the disease, which has hindered the development of effective and mechanism‐specific treatment or prevention strategies both during and after the affected pregnancy. These maternal sequelae of preeclampsia are symptoms of systemic vascular dysfunction in the maternal nonreproductive microvascular beds that drives the development and progression of adverse cardiovascular outcomes during preeclampsia. Despite normalization of vascular disturbances after delivery, subclinical dysfunction persists in the nonreproductive microvascular beds, contributing to an increased lifetime risk of cardiovascular and metabolic diseases and all‐cause mortality. Given that women with a history of preeclampsia demonstrate vascular dysfunction despite an absence of traditional CVD risk factors, an understanding of the underlying mechanisms of microvascular dysfunction during and after preeclampsia is essential to identify potential therapeutic avenues to mitigate or reverse the development of overt disease. This article aims to provide a summary of the existing literature on the pathophysiology of maternal microvascular dysfunction during preeclampsia, the mechanisms underlying the residual dysfunction that remains after delivery, and current and potential treatments both during and after the affected pregnancy that may reduce microvascular dysfunction in these high‐risk women. © 2024 American Physiological Society.
Compr Physiol
14:5703‐5727, 2024.
Combination Energetic Materials Consisting of Strained Rings Combined with High Heat of Formation Tetrazoles
Authors: Zuckerman Jake E. , St Myer Montgomery C. , Zeller Matthias , Piercey Davin G. 
Published: October 2024

AbstractThe reaction of cyanogen azide with strained‐ring containing primary and secondary amines led to the isolation of energetic molecules deriving their energy content from both strained rings as well as aminotetrazoles. Azo‐coupling of these materials afforded novel high‐nitrogen energetic materials of very high sensitivity. All compounds were chemically characterized by IR, NMR, single‐crystal X‐ray crystallography, and high‐resolution mass spectrometry. Their impact and friction sensitivities were experimentally determined, and their energetic performances were calculated.