bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: An Efficient One‐Pot Protocol for the Conversion of Benzaldehydes into Tetrazole Analogues.
Authors: Khan Khalid Mohammed , Fatima Itrat , Saad Syed Muhammad , Taha Muhammad , Voelter Wolfgang 
Published: May 2016

AbstractA tandem transformation of benzaldehydes affords 5‐phenyltetrazoles via non‐isolated oxime and nitrile intermediates.
ChemInform Abstract: Nano‐Zirconia as an Excellent Nano Support for Immobilization of Sulfonic Acid: A New, Efficient and Highly Recyclable Heterogeneous Solid Acid Nanocatalyst for Multicomponent Reactions.
Authors: Amoozadeh Ali , Rahmani Salman , Bitaraf Mehrnoosh , Abadi Fatemeh Bolghan , Tabrizian Elham 
Published: May 2016

AbstractHexahydroquinolines, dioxodecahydroacridines, polyhydroquinolines, and dioxooctahydroxanthenes are prepared by multicomponent cyclocondensations using the title catalyst.
ChemInform Abstract: Synthesis and Cytotoxic Evaluation of Novel Indenoisoquinoline‐propan‐2‐ol Hybrids.
Authors: Nguyen Tuyen Van , et al.  
Published: May 2016

AbstractAn efficient synthetic approach toward nine variously substituted indenoisoquinolines with regard to the lactam nitrogen, starting from the two‐step condensation of 2‐carboxybenzaldehyde and phthalide, followed by the reaction with the appropriate primary amines is reported.
ChemInform Abstract: Dimethylzinc‐Mediated Chlorolactamization of Homoallylic Amines with Chloroform.
Authors: Nishida Yuika , Ueda Masafumi , Hayashi Masataka , Takeda Norihiko , Miyata Okiko 
Published: May 2016

AbstractTreatment of homoallylic amines with dimethylzinc as radical initiator and chloroform as carbon source leads to the formation of the corresponding β‐chlorolactams via Prins‐type cyclization of a carbamoyl chloride intermediate.
ChemInform Abstract: Diazo Strategy for the Synthesis of Pyridazines: Pivotal Impact of the Configuration of the Diazo Precursor on the Process.
Authors: Nikolaev Valerij A. , Cantillo David , Kappe C. Oliver , Medvedev Jury J. , Prakash G. K. Surya. , Supurgibekov Murat B. 
Published: May 2016

AbstractZ‐configured vinylogous diazoesters undergo a diaza‐Wittig reaction providing pyridazines.
ChemInform Abstract: Rhodium(II)‐Catalyzed Carbenoid Insertion of N‐Tosylhydrazones into Amide N—H Bonds: An Efficient Approach to N3‐Benzyl/Alkyl‐2‐arylquinazolinones.
Authors: Lingayya Rajaka , Vellakkaran Mari , Nagaiah Kommu , Nanubolu Jagadeesh Babu 
Published: May 2016

AbstractFor the first time, Rh‐catalyzed reaction of N‐tosylhydrazones and dihydroquinazolinones is reported regioselectively giving the title compounds in good to high yields.
ChemInform Abstract: Synthesis of Novel Dihydronaphthothiazine S,S‐Dioxides by Intramolecular Sulfonylamidomethylation of 2‐Naphthylmethanesulfonamides Using Amberlyst XN‐1010.
Authors: Sasiambarrena Leandro D. , Canepa Alicia S. , Bravo Rodolfo D. 
Published: May 2016

AbstractThe cyclization of sulfonamides (I) with s‐trioxane proceeds with high regioselectivity toward C1 of the naphthalene ring, while cyclization of the 1‐bromo derivative (IV) is directed toward C3.
ChemInform Abstract: Skeletally Diverse Synthesis of Indole‐Fused Diazocine and Diazepine Frameworks by One‐Pot, Two‐Component Cascade Reaction.
Authors: Thikekar Tushar Ulhas , Selvaraju Manikandan , Sun Chung‐Ming 
Published: May 2016

AbstractThe substrate base‐diversification approach offers a straightforward access to a library of compounds with immense interest in drug discovery.
ChemInform Abstract: Syntheses of 1,5‐Benzothiazepines. Part 39. Syntheses and Antimicrobial Studies of 8‐Substituted‐2,5‐dihydro‐2‐(furan‐2‐yl)‐4‐ (2‐hydroxyphenyl/4‐methylphenyl)‐1,5‐benzothiazepines.
Authors: Pant Seema , Dharamveer Dharamveer , Saxena Deepika , Jadon Rajkumari 
Published: May 2016

AbstractThe title benzothiazepines are synthesized by reaction of various substituted aminobenzenethiols with enolizable heterocyclic ketones.
ChemInform Abstract: Copper‐Catalyzed Cycloaddition Between Secondary Phosphine Oxides and Alkynes: Synthesis of Benzophosphole Oxides.
Authors: Zhang Pengbo , Gao Yuzhen , Zhang Liangliang , Li Zhiqiang , Liu Yan , Tang Guo , Zhao Yufen 
Published: May 2016

AbstractThe use of phosphine oxides with substituted aryl moieties results in product mixtures due to rearrangement of the phosphorus substituent, e.
ChemInform Abstract: In‐situ Iodination of Organoarsenic Homocycles: Facile Synthesis of 9‐Arsafluorene.
Authors: Kato Takuji , Tanaka Susumu , Naka Kensuke 
Published: May 2016

AbstractA novel and facile As—C bond formation method is developed and successfully applied to the synthesis of 9‐substituted arsafluorenes (III) and (V).
ChemInform Abstract: Furospirostanol and Spirostanol Saponins from the Rhizome of Tupistra chinensis and Their Cytotoxic and Antiinflammatory Activities.
Authors: Xiang Limin , Wang Yihai , Yi Xiaomin , Feng Jianying , He Xiangjiu 
Published: May 2016

AbstractNine new saponins are isolated and some of them show potent cytotoxic activities against cancer cell lines and significant inhibition on nitric oxide production.
ChemInform Abstract: Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404).
Authors: Kagiyama Ippei , Kato Hikaru , Nehira Tatsuo , Frisvad Jens C. , Sherman David H. , Williams Robert M. , Tsukamoto Sachiko 
Published: May 2016

AbstractThe isolation of taichunamides A—G (I)—(VII) and the elucidation of their structures are reported.
ChemInform Abstract: Neosartoryadins A and B, Fumiquinazoline Alkaloids from a Mangrove‐Derived Fungus Neosartorya udagawae HDN13‐313.
Authors: Yu Guihong , Zhou Guoliang , Zhu Meilin , Wang Wei , Zhu Tianjiao , Gu Qianqun , Li Dehai 
Published: May 2016

AbstractIn addition to neosartoryadins A (Ia) and B (Ib), two new biogenetically related derivatives (IIa,b) are isolated.
ChemInform Abstract: Compositional and Interfacial Modification of Cu2ZnSn(S,Se)4 Thin‐Film Solar Cells Prepared by Electrochemical Deposition.
Authors: Kim Jin Young , et al.  
Published: May 2016

AbstractA highly efficient Cu2ZnSn(S,Se)4 (CZTSSe)‐based thin‐film is prepared by electrochemically depositited on a Mo‐coated glass substrate using an aqueous solution of CuSO4, ZnSO4, SnCl2, and trisodium citrate (1.18 mA/cm2, 1200 s) followed by annealing in a vaporized Se atmosphere (1% H2S/Ar carrier gas; 550 °C, 15 min).
Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450
Authors: Sellars Jonathan D. , Skipsey Mark , Sadr‐ul‐Shaheed  , Gravell Sebastian , Abumansour Hamza , Kashtl Ghasaq , Irfan Jawaria , Khot Mohamed , Pors Klaus , Patterson Laurence H. , Sutton Chris W. 
Published: May 2016

AbstractThe identification and quantification of functional cytochromes P450 (CYPs) in biological samples is proving important for robust analyses of drug efficacy and metabolic disposition. In this study, a novel CYP activity‐based probe was rationally designed and synthesised, demonstrating selective binding of CYP isoforms. The dependence of probe binding upon the presence of NADPH permits the selective detection of functionally active CYP. This allows the detection and analysis of these enzymes using biochemical and proteomic methodologies and approaches.
Assessment of a Heuristic Model for Characterization of Magnetic Nanoparticles as Contrast Agent in MRI
Authors: Félix‐González Nazario , Urbano‐Bojorge Ana Lorena , Mina‐Rosales Alejandra , del Pozo‐Guerrero Francisco , Serrano‐Olmedo José Javier 
Published: May 2016

AbstractIn magnetic resonance imaging (MRI), the use of magnetic nanoparticles (MNPs) as contrast agent (CA) greatly enhances the possibility to identify several diseases hardly diagnosed by other means. The efficacy of a new CA is described by the longitudinal and transverse relaxivity. Nuclear Magnetic Relaxation Dispersion (NMRD) profiles represent the evolution of relaxivities with magnetic field. Many efforts have been taken to develop theoretical models to depict water proton relaxation in presence of magnetic compounds. The use of theoretical models in junction with NMRD profiles has become a powerful tool to characterize MNPs as CA. In this work, a heuristical theoretical model was implemented, verified and assessed with different magnetic materials. It has been demonstrated that the model works well when using iron cores but fails with other magnetic compounds. A weighting factor associated with Langevin function was introduced to the model. This extra calibration enables the model to be used with other magnetic compounds to characterize new CAs in MRI.
Risk of second gonadal cancers in women and children with germ cell tumors
Authors: Liao Zi Wei , Rodrigues Maria Clarissa , Poynter Jenny N. , Amatruda James F. , Rodriguez‐Galindo Carlos , Frazier A. Lindsay 
Published: May 2016

BACKGROUNDMen with testicular cancer have an increased risk of developing cancer in the contralateral testis, but the risks of second gonadal cancers (SGCs) in women and children treated for germ cell tumors (GCTs) have not previously been quantified.METHODSThe incidence of SGCs was ascertained in patients who had survived for at least 1 year after GCT diagnosis using data from the Surveillance, Epidemiology, and End Results SEER 9 registries (1980‐2012). Relative risks of SGCs were estimated separately for boys, women, and girls compared with men based on Poisson regression analysis.RESULTSThe cohort included 21,546 individuals (1116 boys, 827 women, 622 girls, and 18,981 men). A total of 25 SGCs were identified in boys, 1 in women, and 2 in girls compared with 254 in men. The risk of SGC in postpubertal boys (aged ≥10 years) was comparable to that of adult men (boys: standardized incidence ratio, 15.90; 95% confidence interval, 10.29‐23.47; men: standardized incidence ratio, 10.88; 95% confidence interval, 9.58‐12.30). However, no SGCs were observed in boys who were diagnosed with a testicular GCT before age 10 years (N = 179). An elevated risk of SGC was also not observed for women or girls.CONCLUSIONSThe apparent lack of an SGC in prepubertal boys suggests that susceptibility is either age‐dependent and/or histology‐dependent. The sex differences in the risk of SGC suggest differences in the etiology of ovarian versus testicular GCT. The finding that the risk of SGCs in postpubertal boys is similar to that observed in men indicates that long‐term follow‐up for SGC is warranted in postpubertal boys. Cancer 2016;122:2076–82. © 2016 American Cancer Society.
Change in chemotherapy during concurrent radiation followed by surgery after a suboptimal positron emission tomography response to induction chemotherapy improves outcomes for locally advanced esophageal adenocarcinoma
Authors: Ku Geoffrey Y. , Kriplani Anuja , Janjigian Yelena Y. , Kelsen David P. , Rusch Valerie W. , Bains Manjit , Chou Joanne , Capanu Marinela , Wu Abraham J. , Goodman Karyn A. , Ilson David H. 
Published: May 2016

BACKGROUNDA positron emission tomography (PET) scan after induction chemotherapy before preoperative chemoradiation and surgery for esophageal adenocarcinoma predicts outcomes. Some patients with progression on PET after induction chemotherapy had long‐term overall survival (OS) when they were changed to alternative chemotherapy during radiation.METHODSThis study retrospectively reviewed esophageal adenocarcinoma patients who received induction chemotherapy and chemoradiation before planned surgery; all had undergone a PET scan before and after induction chemotherapy.RESULTSThere were 201 patients, and 113 (56%) were PET responders (≥35% decrease in the maximum standardized uptake value of the tumor). All PET responders received the same chemotherapy during radiation, whereas 38 of the 88 PET nonresponders (43%) changed chemotherapy. Among the 152 patients who underwent surgery, the pathologic complete response rate was 15% for PET responders and 3% for PET nonresponders who did not change chemotherapy (P = .046). The median progression‐free survival (PFS; 18.9 vs 10.0 months, P < 0.01) and OS (37 vs 25.3 months, P = .02) were significantly better for PET responders versus PET nonresponders who did not change chemotherapy. The median PFS for PET nonresponders who changed chemotherapy was 17.9 months, and it was superior to the median PFS for PET nonresponders who did not change chemotherapy (P = .01). For PET nonresponders, the 5‐year OS rates were 37% for those who changed chemotherapy and 25% for those who did not change chemotherapy (P = .18).CONCLUSIONSA PET scan after induction chemotherapy predicts outcomes for locally advanced esophageal adenocarcinoma patients who undergo chemoradiation and surgery. The median PFS is improved, and trends toward improved OS appear possible in PET nonresponders who change chemotherapy during radiation. The fully accrued Cancer and Leukemia Group B 80803 study (NCT01333033) is evaluating this strategy. Cancer 2016;122:2083–90. © 2016 American Cancer Society.
Deferred therapy is associated with improved overall survival in patients with newly diagnosed mantle cell lymphoma
Authors: Cohen Jonathon B. , Han Xuesong , Jemal Ahmedin , Ward Elizabeth M. , Flowers Christopher R. 
Published: May 2016

BACKGROUNDDespite efforts at risk stratification in mantle cell lymphoma (MCL), most patients are treated aggressively at the time of diagnosis. Prior reports have suggested that a subset of patients with MCL may safely defer therapy. A national cohort analysis using the National Cancer Data Base was performed to evaluate the role of deferred therapy in MCL.METHODSPatients diagnosed with MCL between 2004 and 2011 were included, and they were divided into deferred‐therapy (time from diagnosis to treatment > 90 days) and immediate‐therapy groups. Differences between the groups were described with chi‐square tests, and multivariate regression models were constructed to identify factors associated with deferred therapy and improved overall survival (OS).RESULTSThere were 8029 patients, and 492 (6%) received deferred therapy with a median time to initial treatment of 121 days (range, 91‐1152 days). Patients who deferred therapy were more likely to have stage I or II disease and extranodal involvement and were less likely to have B symptoms. In addition, deferred patients were more likely to be treated at a high‐volume teaching/research institution and to reside in the Northeast or West region. Deferred therapy was an independent predictor of OS for all patients with MCL. Among patients who deferred therapy, predictors of improved OS included male sex, a younger age, and a lack of comorbidities.CONCLUSIONSDeferred therapy is a safe option for a subset of patients with MCL. Further study is required to better identify the best candidates for deferred therapy according to baseline risk stratification in MCL. Cancer 2016;122:2356–2363. © 2016 American Cancer Society.
The Physics and Physical Chemistry of Molecular Machines
Authors: Astumian R. Dean , Mukherjee Shayantani , Warshel Arieh 
Published: May 2016

AbstractThe concept of a “power stroke”—a free‐energy releasing conformational change—appears in almost every textbook that deals with the molecular details of muscle, the flagellar rotor, and many other biomolecular machines. Here, it is shown by using the constraints of microscopic reversibility that the power stroke model is incorrect as an explanation of how chemical energy is used by a molecular machine to do mechanical work. Instead, chemically driven molecular machines operating under thermodynamic constraints imposed by the reactant and product concentrations in the bulk function as information ratchets in which the directionality and stopping torque or stopping force are controlled entirely by the gating of the chemical reaction that provides the fuel for the machine. The gating of the chemical free energy occurs through chemical state dependent conformational changes of the molecular machine that, in turn, are capable of generating directional mechanical motions. In strong contrast to this general conclusion for molecular machines driven by catalysis of a chemical reaction, a power stroke may be (and often is) an essential component for a molecular machine driven by external modulation of pH or redox potential or by light. This difference between optical and chemical driving properties arises from the fundamental symmetry difference between the physics of optical processes, governed by the Bose–Einstein relations, and the constraints of microscopic reversibility for thermally activated processes.
Biochemical Analysis of Microbial Rhodopsins
Authors: Maresca Julia A. , Keffer Jessica L. , Miller Kelsey J. 
Published: May 2016

AbstractIon‐pumping rhodopsins transfer ions across the microbial cell membrane in a light‐dependent fashion. As the rate of biochemical characterization of microbial rhodopsins begins to catch up to the rate of microbial rhodopsin identification in environmental and genomic sequence data sets, in vitro analysis of their light‐absorbing properties and in vivo analysis of ion pumping will remain critical to characterizing these proteins. As we learn more about the variety of physiological roles performed by microbial rhodopsins in different cell types and environments, observing the localization patterns of the rhodopsins and/or quantifying the number of rhodopsin‐bearing cells in natural environments will become more important. Here, we provide protocols for purification of rhodopsin‐containing membranes, detection of ion pumping, and observation of functional rhodopsins in laboratory and environmental samples using total internal reflection fluorescence microscopy. © 2016 by John Wiley & Sons, Inc.
Teredo tunneling‐based secure transmission between UAVs and ground ad hoc networks
Authors: Sharma Vishal , Kumar Rajesh 
Published: May 2016

SummaryCoordination between distributed ad hoc units requires ambient intelligence to form a guidance system. The network formed by this coordination comprises two variedly operating ad hoc units. One such coordinating network is formed between the unmanned aerial vehicles (UAVs) and the ground nodes. Such network formations require highly sensitive and fault‐tolerant data transfer over the secure channels. A secure channel is required that can ensure the secure connectivity between nodes of the two networks. This secure channel can be realized using a teredo tunneling approach. Using this approach, a service‐oriented security framework is developed. The proposed framework focuses over security in terms of cognitive, corridor, and localization of the multi‐UAV guided system based on the estimation of teredo units using Gauss–Markov‐based α − β − γ filter. The effectiveness of the proposed approach is demonstrated, with significant improvements in terms of system fairness, data delivery ratio, network throughput, and average delays in comparison with the baseline and Hubenko architecture. The proposed model provides 16.25% better fairness, 12% better data rate, 15.7% better throughput, and 10.3% lesser delays than the baseline and 12.9% better fairness, 10% better data rate, 8% better throughput, and 7.9% lesser delays than the Hubenko architecture. Copyright © 2016 John Wiley & Sons, Ltd.
Perceived pain extent is associated with disability, depression and self‐efficacy in individuals with whiplash‐associated disorders
Authors: Falla D. , Peolsson A. , Peterson G. , Ludvigsson M.L. , Soldini E. , Schneebeli A. , Barbero M. 
Published: May 2016

AbstractBackgroundCompletion of a pain drawing is a familiar task in those presenting with whiplash‐associated disorders (WAD). Some people report pain almost over their entire body. Yet the reasons for larger pain extent have not been fully explored.MethodsA novel method was applied to quantify pain extent from the pain drawings of 205 individuals with chronic WAD. Pain extent was evaluated in relation to sex, age, educational level, insurance status and financial status. Multiple linear regression analysis was used to verify whether pain extent was associated with other health indicators including perceived pain and disability, health‐related quality of life, pain catastrophizing, anxiety, depression and self‐efficacy.ResultsPain extent was influenced by sex (χ2:10.392, p < 0.001) with larger pain extent in women compared to men (7.88 ± 7.66% vs. 5.40 ± 6.44%). People with unsettled insurance claims (χ2: 7.500, p < 0.05) and those with a worse financial situation (χ2:12.223, p < 0.01) also had larger pain extent. Multiple linear regression models revealed that, when accounting for age, sex, education, insurance status, financial status and neck pain intensity, pain extent remained associated with perceived disability (p < 0.01), depression (p < 0.05) and self‐efficacy (p < 0.001).ConclusionBy utilizing a novel method for pain extent quantification, this study shows that widespread pain is associated with a number of factors including perceived disability, depression and self‐efficacy in individuals with chronic WAD. Widespread pain should alert the clinician to consider more specific psychological screening, particularly for depression and self‐efficacy, in patients with WAD.What does this study add?Women with chronic WAD, those with unsettled insurance claims and those with poorer financial status perceive more widespread pain.When controlling for these factors, larger pain areas remain associated with perceived pain and disability, depression and self‐efficacy.The pain drawing is useful to support psychological screening in people with chronic WAD.
Just What Is the Disability Perspective on Disability?
Authors: Shakespeare Tom 
Published: May 2016

AbstractIn the helpful article “Why Bioethics Needs a Disability Moral Psychology,” Joseph Stramondo adds to the critique of actually existing bioethics and explains why disability activists and scholars so often find fault with the arguments of bioethicists. He is careful not to stereotype either community—rightly, given that bioethicists endorse positions as disparate as utilitarianism, deontology, virtue ethics, and feminist ethics, among others. Although Stramondo never explicitly mentions utilitarians or liberals, it seems probable that these are the main targets of his discontent. The disability community, as he concedes, is also a broad church. Yet for this reason, I do not believe that you can read off positions on bioethics questions from either disability embodiment or disability organization affiliation.