bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy: The PASSION Study
Authors: McMahon Chris , Lee Sung Won , Kim Sae Woong , Moon Du Geon , Kongkanand Apichat , Tantiwongse Kavirach 
Published: March 2016

Abstract

Introduction
Dapoxetine is a short-acting selective serotonin reuptake inhibitor for treatment of premature ejaculation (PE).

Aim
To evaluate the efficacy and safety of dapoxetine 30 and 60 mg as needed in Asia-Pacific men with PE.

Methods
The study was a prospective, 12-week, open-label study to evaluate the efficacy and safety of flexible-dose dapoxetine in men with PE diagnosed by a Premature Ejaculation Diagnostic Tool score of at least 11, a self-estimated intravaginal ejaculation latency time (IELT) no longer than 2 minutes, and an International Index of Erectile Function erectile function domain score of at least 21.

Main Outcome Measures
Percentage of subjects reporting their PE as at least “slightly better” using the Clinical Global Impression of Change (CGIC) question.

Results
Two hundred eighteen of 285 randomized subjects completed the study. The mean subject age was 45.9 years and 57.7% were Korean. Dosages 1 (30 mg), 2 (30 → 60 mg), and 3 (30 → 60 → 30 mg) were used in 141, 124, and 13 subjects, respectively. At study end, a PE CGIC rating of at least “slightly better” was reported by 77.3%, 92.8%, and 100% of subjects for dosages 1, 2, and 3, respectively (P = .49). At study end, a CGIC rating of “slightly better” was reported by 85.2% and 85.3% of subjects with lifelong PE and acquired PE, respectively (P = .50). At study end, a CGIC rating of “slightly better” was reported by 84.1% and 86.4% of subjects with an estimated baseline IELT no longer than and at least ≤1 minute, respectively (P = .16). The incidence of a CGIC rating of at least “slightly better” was lower in subjects reporting an adverse event of moderate or severe severity and in subjects who increased to and maintained a dapoxetine dose of 60 mg and higher in subjects older than 50 years and in subjects with a baseline estimated IELT of at least 1 minute.

Conclusion
In this study, flexible dosing of dapoxetine (30 and 60 mg) appeared effective in the treatment of PE.
Neonatal exposure to benzo[a]pyrene induces oxidative stress causing altered hippocampal cytomorphometry and behavior during early adolescence period of male Wistar rats
Authors: Patel Bhupesh , Das Saroj Kumar , Das Swagatika , Das Lipsa , Patri Manorama 
Published: March 2016

AbstractEnvironmental neurotoxicants like benzo[a]pyrene (B[a]P) have been well documented regarding their potential to induce oxidative stress. However, neonatal exposure to B[a]P and its subsequent effect on anti‐oxidant defence system and hippocampal cytomorphometry leading to behavioral changes have not been fully elucidated. We investigated the effect of acute exposure of B[a]P on five days old male Wistar pups administered with single dose of B[a]P (0.2 μg/kg BW) through intracisternal mode. Control group was administered with vehicle i.e., DMSO and a separate group of rats without any treatment was taken as naive group. Behavioral analysis showed anxiolytic‐like behavior with significant increase in time spent in open arm in elevated plus maze. Further, significant reduction in fall off time during rotarod test showing B[a]P induced locomotor hyperactivity and impaired motor co‐ordination in adolescent rats. B[a]P induced behavioral changes were further associated with altered anti‐oxidant defence system involving significant reduction in the total ATPase, Na+ K+ ATPase, Mg2+ ATPase, GR and GPx activity with a significant elevation in the activity of catalase and GST as compared to naive and control groups. Cytomorphometry of hippocampus showed that the number of neurons and glia in B[a]P treated group were significantly reduced as compared to naive and control. Subsequent observation showed that the area and perimeter of hippocampus, hippocampal neurons and neuronal nucleus were significantly reduced in B[a]P treated group as compared to naive and control. The findings of the present study suggest that the alteration in hippocampal cytomorphometry and neuronal population associated with impaired antioxidant signaling and mood in B[a]P treated group could be an outcome of neuromorphological alteration leading to pyknotic cell death or impaired differential migration of neurons during early postnatal brain development.
Efficacy, safety, and acceptability of thermocoagulation for treatment of cervical intraepithelial neoplasia in a hospital setting in Brazil
Authors: Naud Paulo S.V. , Muwonge Richard , Passos Eduardo P. , Magno Valentino , Matos Jean , Sankaranarayanan Rengaswamy 
Published: March 2016

AbstractObjectiveTo analyze the acceptability, safety, and effectiveness of thermocoagulation for the treatment of histologically proven cervical intraepithelial neoplasia grade 2–3 (CIN2–3) lesions.MethodsIn a retrospective study, data were obtained for women treated for CIN2–3 lesions by thermocoagulation at the Hospital de Clínicas de Porto Alegre, Brazil, between March 6, 2012, and October 29, 2013, and followed up after 1 year. The proportions of women with no evidence of disease, adverse effects, or complications were determined.ResultsAmong 52 women included, 44 (85%) had no evidence of disease 1 year after thermocoagulation. The rate of no disease at follow‐up was similar for women treated for CIN2 (17/20 [85%]) and CIN3 (27/32 [84%]). No serious adverse effects or complications requiring hospitalization were observed during the follow‐up period.ConclusionThermocoagulation is useful in the management of ectocervical CIN and should be integrated into public health services for management of cervical cancer.
The clinical application of laparoscope‐assisted peritoneal vaginoplasty for the treatment of congenital absence of vagina
Authors: Qin Chenglu , Luo Guangnan , Du Min , Liao Shi , Wang Chunping , Xu Keke , Tang Jie , Li Baoyan , Zhang Juanjuan , Pan Hongxin , Ball Tyler W. , Fang Yujiang 
Published: March 2016

AbstractObjectiveTo evaluate the outcomes of laparoscope‐assisted peritoneal vaginoplasty for the treatment of congenital vaginal atresia.MethodsA retrospective study enrolled patients diagnosed with congenital vaginal atresia who were treated with one of two different laparoscope‐assisted peritoneal vaginoplasty techniques (named Luohu‐one and Luohu‐two) between October 31, 2001 and December 31, 2014. Operative time, intraoperative bleeding volume, surgical difficulty, complications, and post‐procedure sexual satisfaction were reported.ResultsData were collected for 620 patients. The Luohu‐one procedure was used in the treatment of 145 patients, while 475 patients were treated with the Luohu‐two procedure. In 5 (0.8%) patients, it was necessary to perform a sigmoid colon vaginoplasty. During surgery, 16 patients experienced a rectal injury, among whom, 9 patients experienced a rectal–vaginal fistula. Follow‐up data extending to 7 years were available for 285 patients. Of these 285 patients, 231 agreed to report details of their sexual experiences. In total, 222 (96.1%) patients reported being very satisfied with their vaginal conditions and sex life. The Luohu‐two procedure demonstrated shorter operative and recovery time, and reduced intraoperative bleeding. However, both procedures demonstrated satisfactory results.ConclusionLaparoscope‐assisted peritoneal vaginoplasty demonstrated good safety and effectiveness in the treatment of patients with congenital vaginal atresia.
Conventional versus fast track anaesthesia in an unselected group of patients undergoing revisional bariatric surgery
Authors: van Wezenbeek Martin R. , Pouwels Sjaak , Buise Marc P. , Smulders Johannes F. , Nienhuijs Simon W. , van Montfort Gust 
Published: March 2016

ABSTRACT

Introduction:
Fast track care has proven to be safe and effective in primary bariatric procedures. The number of more complex revisional procedures is expected to rise over the next years. The aim was to evaluate the potential benefits and safety of a fast-track protocol in an unselected group of patients undergoing Roux-en-Y Gastric Bypass (rRYGBP) as revision.

Method:
For this retrospective study, all patients undergoing rRYGBP between January 2005 and December 2013 were included and categorized between conventional care (CC) and fast track care (FT). Patient characteristics, operative details and intra- and early postoperative complications < 30 days were analysed.

Results:
A total of 407 patients were included for analysis. 303 patients (74.4%) received peri- and postoperative treatment according to the fast track protocol. Mean age of the study population was 44.0 ± 8.9 years; mean pre-primary procedure BMI was 45.7 ± 7.0 kg/m2. A total of 54 (13.3%) postoperative complications were registered (CC 19.2% vs FT 11.2%; p
= 0.038). Both operative time (CC 135.3 ± 42.6 minutes vs FT 79.3 ± 29.3 minutes; p < 0.001) as well as hospital stay (CC 5.1 ± 6.3 days vs FT 3.1 ± 5.3 days; p < 0.001) were significantly shorter in the FT group. A multivariate analysis on postoperative complications showed that fast track was not predictive for the occurrence of complications (OR = 0.853; 95% CI [0.403–1.804]; p
= 0.677).

Conclusion:
Fast track care appears to be safe and efficient for patients undergoing revisional Roux-en-Y gastric bypass, but postoperative outcome may be highly dependent on surgical experience.

Highlights:
Evolution of the Paleozoic granitoid magmatism in the Kuznetsk Alatau: new geochemical and U–Pb (SHRIMP-II) isotope data
Authors: Vrublevskii V.V. , Kotel’nikov A.D. , Rudnev S.N. , Krupchatnikov V.I. 
Published: March 2016

Abstract
A U–Pb isotope analysis has revealed zircons, dated at ~ 510–490 and ~ 430–400 Ma, in granitoid intrusions on the eastern slope of the Kuznetsk Alatau Range (Batenev Ridge). This suggests two stages of the regional granitoid magmatism: Middle–Late Cambrian and Silurian–Early Devonian. The ages of two zircon grains from the rocks of the Tigertysh pluton are ~ 1.9 and ~ 2.6 Ga; they suggest the involvement of fragments of the Paleoproterozoic continental crust in magma generation. The granitoids, independently of their age, are mostly products of rocks of the calc-alkalic (K2O/Na2O ≈ 0.5–1.7) series. In the proportions of alumina, calcium, and alkalies most of them correspond to I-type granites (A/CNK≤1.1) with reduced Fe/(Fe + Mg) values and contents of HFSE, including REE (ΣREE ≈ 100–300 ppm). The trace-element patterns of the rocks point to the possible participation of both IAB and OIB in magma genesis. Presumably, the influence of the within-plate component increased as a result of the superposition of plume on accretion–collisional structures, and their melting might have favored the preservation of geochemical features of subduction magmatism in the granitoids. The isotopic inhomogeneity (εNd(T) = 2.3–4.8, (87Sr/86Sr)T ≈ 0.7036–0.7051) of the granitoid complexes suggests the heterogeneous composition of the material sources, which consisted of the matter of moderately depleted (PREMA) and enriched (EM) lithospheric mantle and crustal substrate, mixed in different proportions. Some products of the regional alkali-basic magmatism are coeval with the Cambrian granitoids of the Kuznetsk Alatau and are similar to them in isotope composition. This magmatism confirms the interaction of plume with the active continental margin at the Caledonian stage of evolution of the Central Asian Fold Belt.
New data on the structure and age of the terminal Permian strata in the South Verkhoyansk region (northeastern Asia)
Authors: Biakov A.S. , Zakharov Yu.D. , Horacek M. , Richoz S. , Kutygin R.V. , Ivanov Yu.Yu. , Kolesov E.V. , Konstantinov A.G. , Tuchkova M.I. , Mikhalitsyna T.I. 
Published: March 2016

Abstract
We present new data on the structure and age of the upper Permian strata in the basin of the Setorym River (tributary of the Vostochnaya Khandyga River) in the South Verkhoyansk region, represented by the Imtachan Formation and the lower part of the Nekuchan Formation. Based on the new findings of bivalve fossils from the Intomodesma costatum Zone, as well as on the study of carbon isotopes in the shells and carbon isotopes of the organic matter of the host mudstones, we have for the first time proved the completeness of the Permian section. The detailed description of the contact between the Imtachan and Nekuchan Formations bears evidence for a certain continuity of the lithologic characteristics of the sandstones. The sharp lithologic contact between the formations reflects not a regional sedimentation hiatus but a shift of depositional settings from the upper parts of a delta to the deep shelf, caused by forced marine transgression. It is concluded that there was no long-term hiatus between the accumulation of the Imtachan and Nekuchan Formations. Images of the most characteristic species of bivalves and crinoids from the Imtachan Formation are presented.
The Paleogene/Neogene boundary in continental deposits of the West Siberian Plain
Authors: Volkova V.S. , Kuz’mina O.B. , Gnibidenko Z.N. , Golovina A.G. 
Published: March 2016

Abstract
This paper presents palynological and paleomagnetic characteristics of three West Siberian horizons: Zhuravka (Upper Oligocene, Chattian), Abrosimovka, and Beshcheul (Lower–Middle Miocene, Aquitanian, Burdigalian, Langhian, and Serravallian). We consider the distribution of dinocysts of the genus Pseudokomewuia in the stratotype section of the Zhuravka Horizon (Zashchitino Village) and in the section of borehole 13 (Chelyuskintsev Village), which exposes the Turtas, Abrosimovka, and Beshcheul Formations. Similar compositions and structures of dinocyst assemblages and similar palynofloras in the Turtas and Abrosimovka Horizons, as well as the sedimentation environment and cyclic structure of lacustrine deposits, suggest that the Paleogene/Neogene boundary should be localized at the base of the Beshcheul Horizon. We propose to include the Abrosimovka Horizon into the Upper Oligocene (upper Chattian). The data are correlated with the regional paleomagnetic scale. These views should be reflected in a new regional stratigraphic chart for the Paleogene–Neogene deposits of the West Siberian Plain.
The impact of a specialized inpatient and day patient group programme on clinical outcome in older adolescents and young adults with mental illness
Authors: McCrossan P. , Ryan A. , Connellan M. , Power P. 
Published: March 2016

IntroductionEffective transition from child and adolescent mental health services (CAMHS) to adult services is one of the main challenges currently facing child psychiatry todayThe Young Adult 1Programme (YAP) based at St. Patrick’s University Hospital Dublin, is a group based day programme especially designed to meet the needs of younger people aged 18–25 and support them through this difficult period.AimsTo examine the effectiveness of participation in YAP for young adults with mental illness. To determine whether participation in particular aspects of the programme prove more beneficial and what factors might be associated with outcome.MethodAll patients enrolled in YAP between 1 September 2011 and 31 August 2012 were included in the study. Each patient was assessed using the Health of the Nation Outcome Scales (HONOS) and Global Assessment of Functioning (GAF) rating scale before beginning the programme and after discharge in order to evaluate improvement. The frequency of attendance at individual group sessions was recorded. Patient and illness variables were also recorded, for example demographics, diagnosis.ResultsA total of 101 service users were in enrolled in YAP during this 12-month period. Eight service users could not be used for analysis, as they did not have a complete data set, mostly due to failure to attend for discharge HONOS/GAF ratingsUsing a paired samplet-test, there is a significant reduction in HONOS: Mean df=1.3,s.d.=1.09 (95% CI=1.08–1.53),p<0.001Using a paired samplet-test, there is a significant increase in GAF: Mean df=9.25,s.d.=7.69 (95% CI=7.66–10.83),p<0.001Improvements in HONOS and GAF scores are significantly correlated with better attendance at the programme (p<0.04, <0.00 respectively).ConclusionMore attendance at YAP sessions correlates with better improvement in both HONOS and GAF rating scores.
Developing, Managing, and Sustaining an Effective International Tobacco Dependence Treatment Partnership
Authors: Kemper Katherine E. , Hurt Richard D. , Hays J. Taylor , Glynn Thomas J. , Wysocki Karla 
Published: March 2016

Introduction: Global Bridges, hosted at Mayo Clinic since 2010, is the only international network of healthcare professionals dedicated to tobacco dependence treatment. Globally, fewer resources have been dedicated to treatment than to other evidence-based tobacco control policies. The Global Bridges network seeks to aid in filling this gap in tobacco control.Aims: This paper identifies ways to advance tobacco dependence treatment, as well as tobacco control, through efficient and effective use of a global health care provider network.Methods: Observation and critical analysis of lessons learned, project outcomes to date, and network analysis.Results/Findings: The initiative has built a strong global foundation, with training curricula developed and delivered in a number of countries, including low- and middle-income countries. While basic evaluation of content mastery and learner satisfaction has been conducted, more intensive evaluation and follow-up to confirm public health impact are essential needs. Finally, program analysis and application of management theory can be used in aiding future activities aimed at providing support for health care providers in the delivery of tobacco dependence treatment and in similar global public health endeavors.Conclusions: The Global Bridges healthcare professional network, now in its sixth year, has developed training curricula and expanded evidence-based tobacco dependence education among healthcare professionals. Global Bridges comprises a unique and important component of the broader tobacco control community, and can play an integral role in furthering global tobacco control progress.
Dietary patterns of obese and normal-weight women of reproductive age in urban slum areas in Central Jakarta
Authors: Yulia  , Khusun Helda , Fahmida Umi 
Published: March 2016

AbstractDeveloping countries including Indonesia imperatively require an understanding of factors leading to the emerging problem of obesity, especially within low socio-economic groups, whose dietary pattern may contribute to obesity. In this cross-sectional study, we compared the dietary patterns and food consumption of 103 obese and 104 normal-weight women of reproductive age (19–49 years) in urban slum areas in Central Jakarta. A single 24-h food recall was used to assess energy and macronutrient intakes (carbohydrate, protein and fat) and calculate energy density. A principal component analysis was used to define the dietary patterns from the FFQ. Obese women had significantly higher intakes of energy (8436·6 (sd2358·1)v. 7504·4 (sd1887·8) kJ (2016·4 (sd563·6)v. 1793·6 (sd451·2) kcal)), carbohydrate (263·9 (sd77·0)v. 237·6 (sd63·0) g) and fat (83·11 (sd31·3)v. 70·2 (sd26·1) g) compared with normal-weight women; however, their protein intake (59·4 (sd19·1)v. 55·9 (sd18·5) g) and energy density (8·911 (sd2·30)v. 8·58 (sd1·88) kJ/g (2·13 (sd0·55)v. 2·05 (sd0·45) kcal/g)) did not differ significantly. Two dietary patterns were revealed and subjectively named ‘more healthy’ and ‘less healthy’. The ‘less healthy’ pattern was characterised by the consumption of fried foods (snacks, soyabean and roots and tubers) and meat and poultry products, whereas the more healthy pattern was characterised by the consumption of seafood, vegetables, eggs, milk and milk products and non-fried snacks. Subjects with a high score for the more healthy pattern had a lower obesity risk compared with those with a low score. Thus, obesity is associated with high energy intake and unhealthy dietary patterns characterised by consumption of oils and fats through fried foods and snacks.
Olfactory event-related potentials: a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapy
Authors: Galletti B , Santoro R , Mannella V K , Caminiti F , Bonanno L , De Salvo S , Cammaroto G , Galletti F 
Published: March 2016

AbstractObjective:Olfactory dysfunction is a possible side effect of chemo-radiotherapy performed in patients affected by nasopharyngeal carcinoma. Self-rating measurements and olfactory event-related potentials were used and compared in order to evaluate the impact of this treatment on the olfactory system.Methods:Nine patients underwent subjective evaluation of olfactory function (using visual analogue scales for olfactory symptoms and quality of life, and a six-item Hyposmia Rating Scale), and a quantitative and objective measurement (olfactory event-related potentials).Results:Spearman's rank correlation analyses highlighted significant relationships between the clinical scales and olfactory event-related potentials. Inter-group analyses showed significant differences in the latency and in the amplitude of olfactory event-related potentials between patients and controls.Conclusion:Taking into account the small sample size and the lack of pre-treatment assessment, olfactory event-related potentials seemed to allow a more objective diagnosis of unilateral and bilateral olfactory loss. Moreover, olfactory event-related potentials and subjective scales results were concordant.
Presence of an isoform of H+-pyrophosphatase located in the alveolar sacs of a scuticociliate parasite of turbot: physiological consequences
Authors: MALLO NATALIA , LAMAS JESÚS , DEFELIPE ANA-PAULA , DECASTRO MARIA-EUGENIA , SUEIRO ROSA-ANA , LEIRO JOSÉ-MANUEL 
Published: March 2016

SUMMARYH+-pyrophosphatases (H+-PPases) are integral membrane proteins that couple pyrophosphate energy to an electrochemical gradient across biological membranes and promote the acidification of cellular compartments. Eukaryotic organisms, essentially plants and protozoan parasites, contain various types of H+-PPases associated with vacuoles, plasma membrane and acidic Ca+2storage organelles called acidocalcisomes. We used Lysotracker Red DND-99 staining to identify two acidic cellular compartments in trophozoites of the marine scuticociliate parasitePhilasterides dicentrarchi: the phagocytic vacuoles and the alveolar sacs. The membranes of these compartments also contain H+-PPase, which may promote acidification of these cell structures. We also demonstrated for the first time that theP. dicentrarchiH+-PPase has two isoforms: H+-PPase 1 and 2. Isoform 2, which is probably generated by splicing, is located in the membranes of the alveolar sacs and has an amino acid motif recognized by the H+-PPase-specific antibody PABHK. The amino acid sequences of different isolates of this ciliate are highly conserved. Gene and protein expression in this isoform are significantly regulated by variations in salinity, indicating a possible physiological role of this enzyme and the alveolar sacs in osmoregulation and salt tolerance inP. dicentrarchi.