bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efeitos da terapia contra o Câncer na fertilidade de mulheres em idade fértil: uma revisão de literatura
Authors: Cruz Danielle Barbosa , Gomes Adriana Vieira 
Published: September 2024

Introdução: Os efeitos do câncer e seu tratamento farmacológico em função da reprodutividade feminina vem sendo documentado desde 1970. Diante disso, relatos de amenorréia, destruição de folículos e supressão ovariana vem sendo documentada. É notória a dificuldade de determinar em particular qual combinação de drogas seria a responsável pelos efeitos na fertilidade, visto que existem poucas evidências sobre a toxicidade ovariana, mas observa-se alteração na função uterina compatível com a infertilidade. Objetivo: Caracterizar os efeitos da terapia contra o câncer na fertilidade de mulheres em idade reprodutiva. Metodologia: Trata-se de um estudo de revisão integrativa de literatura, realizada através da busca dos descritores: “Substâncias para a Infertilidade Feminina”, “Aparelho Reprodutor Feminino”, "Câncer" e “Preservação da Fertilidade” nas plataformas: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS); Scientific Electronic Library Online (SciELO), Biblioteca Virtual em Saúde (BVS). Foram incluídas publicações realizadas no período de 2013 até 2023, com artigo completo disponível nos idiomas português, inglês ou espanhol. Excluíam-se estudos duplicados, artigos que não respondiam à questão norteadora e estudos não publicados como artigos. Resultados: A revisão sistemática analisou 5.610 artigos, selecionando 19 com base em descritores específicos. Ensaios clínicos, estudos de corte e meta-análises predominaram nos desenhos de estudo. Destacam-se os impactos do câncer na fertilidade, com sobreviventes de câncer de mama, colo do útero e cérebro apresentando significativa redução nas chances de gestação após cinco anos do diagnóstico. Sobreviventes de câncer na infância e adolescência, especialmente homens, têm menor probabilidade de ter o primeiro filho vivo. A quimioterapia influencia a capacidade do tecido ovariano criopreservado, ressaltando a importância da preservação da fertilidade antes de agentes alquilantes. Considerações finais: O aconselhamento personalizado, considerando idade, reserva ovariana e tipo de quimioterapia, é crucial. Impactos nos órgãos reprodutivos, como o útero, são observados. Estratégias inovadoras, como mangafodipir, inibidores de CHK2, hormônio luteinizante (LH) e inibidores de ATR e CHK1, surgem como alternativas promissoras.
A febre dos cigarros eletrônicos e suas repercussões negativas na saúde dos adolescentes
Authors: Santos Lorena de Souza , Trigueiro José Júnio Martins , Cristovão Laura Rodrigues , Rocha João Pedro Barbosa , Varela Raquel Correia , Cristovão Juliana dos Santos , Miranda Fernanda Barreto Rosado de , Sousa Raquel Nóbrega de , Lima Gabrielle Fernandes , Rios Manuela Oliveira , Rios Maria Aparecida Ferreira de Oliveira , Ana Ana Clara Dias Santa , Andrade Camila Idalino de 
Published: September 2024

É inquestionável que o uso de cigarros eletrônicos (CE) pelos adolescentes ganhou um grande destaque nos últimos anos. Estudos realizados em jovens dos EUA constatou que houve um aumento do uso de CE por esses indivíduos entre 12 e 17 anos de 48%para 78% nos anos de 2017 a 2018, e isso reflete um potencial risco à saúde.1 Contudo, as informações sobre o CE ainda estão limitadas, possuem procedência duvidosa e não trazem segurança aos usuários.O objetivo desse artigo, é de elucidar análises de estudos a respeito dos impactos relacionados ao uso crônico desses dispositivos, ressaltando as diferenças existentes entre os “e-cigarettes” e o cigarro convencional. Desse modo, mesmo a composição química existente entre eles sendo semelhante, ainda existem diferenças, principalmente no que se refere à concentração dos compostos sendo maior no cigarro convencional. No entanto, no que tange aos CE, apesar de parecerem inofensivos, o uso frequente pelos jovens pode acarretar diversos prejuízos à saúde, o que será enfatizado no decorrer desta revisão literária.
A prevalência da fadiga por compaixão em profissionais socorristas de resgate do Corpo de Bombeiros Militar do estado de Alagoas
Authors: Silva Maria Karoline Gomes da , Otoni Andreza Serpa , Oliveira Bruna Tavares , Sobrinho Caroline Magalhães Tenório Rocha , Figueira João Rubens Ribeiro , Carnaúba Aline Tenório Lins , Peixoto Audenis Lima de Aguiar , Calixto Gabriel Ferreira de Oliveira 
Published: September 2024

A fadiga por compaixão caracteriza-se pela exaustão emocional e física provocada pela exposição ao estresse contínuo em lidar com o sofrimento alheio, apresentando-se como uma ameaça a qualidade de vida de profissionais de ajuda, especificamente. Objetiva-se analisar a prevalência de fadiga por compaixão em socorristas de emergência, traçar o perfil sociodemográfico e ocupacional dos profissionais socorristas de emergência e identificar possíveis fatores de risco. Trata-se de um estudo analítico, observacional transversal, realizado no Corpo de Bombeiros Militar de Alagoas, através coleta de dados online por meio da ferramenta Google Forms. Foram entrevistados 142 participantes, dos quais obteve-se que a maior parte são do sexo masculino, casados, apresentam apenas um filho e possuem ensino superior completo. Além disso, possuem cargos de 1º/2º ou 3º sargento e possuem entre 10 e 20 anos de experiência no Corpo de Bombeiros Militar de Alagoas e afirmam realizar horas extras. Nisso, foi visto que 31,5% dos entrevistados apresentaram algum grau de sintomas para Fadiga por Compaixão e 46,6% apresentaram traços de Burnout em contrapartida, 59,5% apresentaram altos índices de Satisfação por compaixão. Altas cargas horárias de trabalho foram constatadas como fator de risco para piora da qualidade de vida profissional. Diante disso, o estudo destacou a necessidade de implementar programas de apoio e estratégias para promover a resiliência e o bem-estar psicológico, além de fortalecer as políticas de saúde mental. A continuidade das pesquisas é essencial para entender melhor os fatores de risco e melhorar as práticas de prevenção e tratamento.
Effect of foliar application and fertigation on micronutrient absorption efficiency and productivity of sweet pepper in calcareous soil in Iraq
Authors: Al-Ogaidi Ziyad A. Humod , Alwan Bushra Mahmoud 
Published: September 2024

A field experiment was carried out in a private greenhouse farm located in Al-Madaen city / old Diyala Bridge / Western Tuwaitha village (N 44, 29,47-E 36, 33,11) in the agricultural season 2020/2021 to study the effect of micronutrient absorption efficiency and yield of sweet pepper was grown in calcareous soil, Dutch Olombus sweet pepper was planted and used the nutrients (manganese at a concentration of 30 mg.l-1, copper at ca concentration of 25 mg.l-1. Iron at a concentration of 50 mg.l-1, zinc at a concentration of 60 mg.l-1, The factorial experiment was carried out according to the split-plot design with two methods of nutrients application, one by spraying on shoots foliar application and the other with irrigation water, 16 treatments were used for each method of addition, which consisted of single, double, triple and quadruple addition of the nutrients that used in the experiment, with the control treatment for each method of addition and with three replicates for each treatment, there were 30 additions duration of the experiment, the first edition took place after two weeks of cultivation in the field, the period between each addition was one week, and the macronutrients N, P, K were used in concentrations (425 Kg N ha-1,175kg P ha-1 and 250 kg K ha-1 ), the results of highest cumulative yield was for the Fe+ Zn+ Mn treatment which added by spraying on shoots, which amounted to 159.15 Mg h-1., It also showed a highly significant superiority for all treatments of adding micronutrients sprayed on the shoot over the corresponding treatments of adding these nutrients with irrigation water on the efficiency of absorption of micronutrients in the fruits of the sweet pepper plant. The Fe+ Mn treatment gave the highest value for the iron absorption efficiency of 341.3%, while the Zn+ Mn+ Cu treatment gave the highest value for the zinc absorption efficiency of 113.17%. As for the manganese absorption efficiency, the Fe+ Mn treatment gave the highest value of 517.2%. As for the absorption efficiency of copper, the Fe+ Mn+ Cu treatment gave the highest value of 217.2%.
Role of Polyethylene Glycol in production of Anticancer Alkaloids Vincristine, Vinblastine, and Vindoline in Catharanthus roseus via Callus Culture
Authors: Abdulwahid Zainab , Al-Musawi Abdulminam Hussien Ali , Lafta Abdullah Hamad 
Published: September 2024

Periwinkle Cathranthus roseus is an ornamental plant that produces over 200 alkaloids, including vincristine, vinblastine, and vindoline, which are used to treat various types of cancer. However, the low yield of terpenoid indole alkaloids (TIAs) from periwinkle and the high cost of extraction has led researchers to explore alternative methods for their production. The study aims to investigate the influence of polyethylene glycol (PEG) as an elicitor to enhance alkaloid production in periwinkle callus cultures while examining the efficacy and safety of using PEG. Callus was induced and abiotic elicitation experiments were conducted to study callus growth enhancement. The dry weight of the callus was calculated, and vincristine, vinblastine and vindoline were extracted and analyzed using high-performance liquid chromatography. The results showed that low to moderate concentrations of PEG4000 can enhance callus growth, while higher concentrations can reduce it. The addition of PEG4000 also increased the production of important alkaloids, including vindoline, vincristine, and vinblastine, by up to 2.65-fold. The findings suggest that PEG4000 can be used to optimize the production of alkaloids in C. roseus callus cultures.
Penerapan Pembelajaran Berdifferensiasi Untuk Meningkatkan Kemampuan Pemecahan Masalah Matematika
Authors: Lestariani Sri , Zahari Cut Latifah , Salayan Madyunus , Destiani Rista 
Published: September 2024

This study aims to apply differentiated learning to improve mathematical problem solving skills. This study uses a Classroom Action Research (CAR) design. This research consists of a cycle in cycle I which consists of four stages, namely (1) planning, which is the first stage in the research, the first stage which is carried out by compiling a learning plan and research instruments in accordance with the previous stages, (2) implementation, at the beginning of this the researcher carries out the learning process in accordance with the learning plan which has been previously planned, (3) implementation, this stage is carried out throughout the learning process to carry out all student activities in the implementation activities. test instrument to see students' problem solving abilities (4) reflection, this is done to find out the advantages and disadvantages of the learning process that has been carried out. This research was carried out at SMPN 2 Rawa Belonging with research subjects being students of class VII-1 in the academic year 2023/2024 with a total of 30 students consisting of 14 male students and 16 female students. Based on the results of this study, it is shown that the results of the test of students' mathematical problem solving ability increase for each cycle, so it can be concluded that the implementation of differentiated learning can increase students' mathematical problem solving ability. Keywords: Application, Differentiated Learning, Mathematical Problem Solving Ability
Pembuatan Arang Aktif Dari Cangkang Pala (Myristica Fragrans Houut) Dan Aplikasinya Untuk Penjernihan Asap Cair Serta Analisis FTIR.
Authors: Gomes Esri , Lombok John , Caroles Joice 
Published: September 2024

Research on activated charcoal from nutmeg shells (Myristica Fragrans Houut) and its application for liquid smoke clarification and FTIR analysis has been carried out. This study aims to determine the functional groups and composition of nutmeg shell charcoal from Siau Island. This research includes pyrolysis stage, charcoal activation stage and functional group analysis with Fourier Transform Infra-Red (FTIR). The FTIR test results of pyrolyzed nutmeg shell charcoal and the results of activation with , and show the functional groups O-H, C-H Aromatic, C-H Aliphatic, C=C, and C-O which are the composition of the carbon material of nutmeg shell charcoal. The results of testing the physical and chemical properties of nutmeg shell charcoal, namely nutmeg shell charcoal resulting from activation with namely Moisture Content 0.533%, Ash Content 0.653%, Volatile matter content 0.406%, Bonded carbon content 40.70%. The test results for the physical properties of nutmeg shell charcoal activated with were 0.483 water content, 0.4% ash content, 0.403% volatile matter content, and 41.13% bound carbon content. The results of purifying liquid smoke with activated carbon produce reduced turbid water color, reduced smoke odor and a Ph value of 5, while liquid smoke clarification without activated carbon produces cloudy/brownish water color, pungent smoke odor and a pH value of 4.
The Role of Corporate Image, Quality Service and Customer Satisfaction To Intention Behavior and Customer Loyalty
Authors: Ardhana Nugroho Aji , Mariam Siti , Ramli Abdul Haeba 
Published: September 2024

This study aims to investigate the relationship between corporate image, service quality, customer satisfaction, behavioral intention, and customer loyalty at PT Indomarco Prismatama ( Indomaret ). The research utilizes a quantitative approach with a descriptive design, involving 155 respondents selected through purposive sampling. Data were collected using an online questionnaire and analyzed using Partial Least Squares – Structural Equation Modeling (PLS-SEM). The findings indicate that corporate image positively and significantly influences customer satisfaction, which in turn influences behavioral intention and customer loyalty. Additionally, service quality is shown to positively impact both corporate image and customer satisfaction. Validity and reliability tests confirm that all variables in the model exhibit good quality. The study supports all proposed hypotheses and is consistent with previous research, highlighting the importance of corporate image, service quality, and customer satisfaction in influencing behavioral intention and customer loyalty. Managerial implications include the need to focus on enhancing service quality and strengthening corporate image to increase customer satisfaction and loyalty. Limitations of the study include the restricted sample scope to the Jabodetabek area and the use of online data collection methods. Future research is recommended to expand the sample scope and consider longitudinal approaches.

Keywords: Corporate Image, Service Quality, Customer Satisfaction, Behavioral Intention, Customer Loyalty.
Attracting talent as a catalyst for sustaining learning organisations — a South African perspective
Authors: Abiwu Lawrence , Martins Isabel 
Published: September 2024

Orientation: Although talent is a strategic asset for achieving organisational success, most higher education institutions (HEIs) struggle to attract talented academics required to compete.Research purpose: The primary purpose of this study was to examine talent attraction practices that create a competitive advantage for South African HEIs.Motivation for the study: The study was necessary to enhance the competitiveness of HEIs through talent attraction practices such as recruitment and selection, job analysis and employer branding.Research approach/design and method: The concurrent mixed-methods approach was used to analyse the quantitative and qualitative data independently. A sample size of 347 was selected from three South African HEIs. However, the data were collected from only 277 respondents using questionnaires (265) and interviews (12). The quantitative data were analysed using Statistical Package for the Social Sciences (version 27.0) and Analysis of Moment Structures (version 29.0). The qualitative data were analysed using thematic analysis.Main findings: The quantitative results showed a significant positive relationship between recruitment and selection, job analysis, employer branding and competitive advantage. The qualitative findings confirmed that talent attraction strategies created a competitive advantage for HEIs by hiring highly talented employees.Practical/managerial implications: The research findings could be a viable tool to create value for HEIs by adopting different talent attraction strategies to acquire highly talented employees.Contribution/value-add: This study sheds more light on the talent attraction practices that create value for HEIs.
Survival of female patients with breast cancer in the reproductive age group: A retrospective study using SEER database
Authors: Priyadarshini Subhadra , Panda Kunja Bihari 
Published: September 2024

ABSTRACT

Background:
Breast cancer is the most prevalent cancer in women worldwide. The progressive rise in breast cancer incidence in young and reproductive-aged women is a cause for concern.

Objectives:
The primary objective of this study was to investigate the survival of patients with breast cancer in women from the reproductive age group (15-49 years). The secondary objective was to identify significant factors associated with their survival.

Materials and Methods:
This retrospective study was performed in the Department of Statistics, Utkal University, Odisha, India. We utilized data from the Surveillance, Epidemiology, and End Results (SEER) database, specifically from November 2020, covering 2000 - 2018, maintained by the National Cancer Institute. The Kaplan-Meier non-parametric estimation technique was used for survival estimation, and standard Cox proportional hazard (PH) and Cox PH with a gamma frailty term were employed to determine significant potential determinants.

Results:
Among women with breast cancer in the reproductive age group, the average survival time was 97.4 months (8.1 years), and the overall survival probability was 0.836. Young women (< 40 years) with breast cancer had poorer survival and a higher risk of death. An increasing incidence of HR+/HER2-subtype of breast cancer was present in 65% of women in this age group. Women with distant metastasis faced a significantly elevated risk (hazard ratio [HR], 66.66, 95% confidence interval [CI], 61.11–72.71), approximately 67 times higher, compared to those with localized staged breast cancer. Furthermore, the ER−/PR+/HER2- group (HR, 6.50; 95% CI, 5.25-8.03) had a similar increased risk of mortality as those in the triple-negative group (HR, 6.25; 95% CI, 5.83-6.71).

Conclusion:
Young women (15–49 years) consistently have a higher risk of breast cancer recurrence or death as compared to older women (> 49 years). This study provides evidence that the ER/PR/HER2 status is an important prognostic factor and should be considered in the management and treatment decisions for patients with breast cancer in this population.
Study of frequency and prognostic significance of HER2 overexpression by immunohistochemistry in high-risk endometrial cancer: A retrospective cohort study
Authors: Gupta Saumya , Bhati Priya , Nair Indu R. , Kartha Niveditha , Pavithran Keechilat , Rajanbabu Anupama 
Published: September 2024

ABSTRACT

Background:
The prognostic significance of human epidermal growth factor receptor 2 (HER2) as assessed by immunohistochemistry (IHC) in high-risk endometrial carcinoma (EC) is worth evaluating, owing to limited literature for the Asian population.

Objectives:
The primary objective of the study was to evaluate the role of HER2 expression as a prognostic indicator of recurrence-free survival in patients with high-risk endometrial cancer. The secondary objectives were to evaluate overall survival and the frequency of HER2 expression, along with other clinicopathological profiles.

Materials and Methods:
This retrospective cohort study was conducted in Gynecological oncology Department of Amrita Institute of Medical Sciences, Kochi, India, a tertiary care oncology center. The study included high-risk prognostic group of patients with EC from January 2014 to December 2020. HER2 immunohistochemistry was done using EP3 (HER2 neu antibody) clone, with complete basolateral membrane staining of >30% of tumor cells (3+) considered positive. Outcome data were analyzed for both HER2-positive and HER2-negative groups.

Results:
Thirty-one HER2-positive and 39 HER2-negative patients were eligible for survival analysis. HER2-positive status was significantly associated with non-endometrioid histotype (P, 0.044). HER2 positivity was observed in 42.9% (18/42) of serous carcinomas, and 40% (4/10) of carcinosarcomas. In the HER2-positive group, 22.5% (7/31) experienced recurrence, compared to 43.5% (17/39) in the HER2-negative group. Mortality rates were 38.4% (15/39) in the HER2-negative group and 41.9% (13/31) in the HER2-positive group. Mean recurrence-free survival (RFS) at 4 years and overall survival (OS) at 5 years were not statistically significant between the two groups (P, 0.097, and P, 0.813, respectively). The mean RFS at 4 years was 34.89 months (95% CI, 30.11- 39.66 months) in the HER-2 negative group and 38 months (95% CI, 31.36-44.64 months) in HER2-positive group. Mean OS at 5 years was 41.68 months (95% CI, 34.83-48.52 months) in HER2-negative and 39.58 months (95% CI, 31.08-48.09 months) in HER2-positive group.

Conclusion:
HER2 overexpression was not found to be an independent prognostic indicator of RFS or OS in high-risk EC in this study.
Strengthening of cancer care services in Bihar: A situational analysis
Authors: Raj Shraddha , Goel Akhil D. , Upadhyay Vivekanand , Singh Rajesh K. , Bhardwaj Pankaj 
Published: September 2024

ABSTRACT

Background:
The status of cancer care in Bihar is in elementary stages, with limited knowledge of epidemiology and insufficient comprehensive cancer care centers. State Cancer Institute (SCI) of Bihar is actively working to address these gaps by continuously upgrading its facilities and services.

Objectives:
The present article aims to define the problem and conduct a situational analysis for strengthening cancer care services in Bihar through the expansion and integration of services at SCI, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna.

Materials and Methods:
A problem statement was initially developed following a comprehensive review of the literature from January 2023 to September 2023, with an updated review conducted in August 2024. Full-text articles containing the keywords “cancer,” “incidence,” and “Bihar” were searched on PubMed and manually screened for relevance based on titles and abstracts. Additional information was collected through Google searches of public domain websites and newspaper portals, and relevant articles were also identified through a manual review of references. Furthermore, a situational analysis was conducted using SWOT analysis and power-interest matrix to identify and evaluate the stakeholders.

Results:
Accurate cancer incidence data for Bihar are lacking. Almost half of the estimated new cancer cases seem to be registered within the state, while the rest remain unaccounted. Presently, there are only eight comprehensive cancer centers operational in the state. The SWOT analysis highlighted opportunities for SCI based on inherent strengths, while limited manpower and inadequate collaborations were identified as critical weaknesses. Key stakeholders were identified as the crucial players in mitigating threats and supporting positive policy and financial frameworks.

Conclusion:
Properly addressing the needs of stakeholders and fully utilizing available opportunities are essential for strengthening healthcare services in the state. The SCI could play a vital role in the process. The article also provides background on devising strategies to address the current cancer care needs of the state.