bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of PCM tile for residential buildings in hot and dry climate: design and optimization
Authors: D. Prakash , R. Vishore Krishnan , S. Rizwan Ahamed , H. Roger Arnold 
Published: October 2024

AbstractIn recent years, the building sector has become more conscious of sustainability, and the use of phase change materials (PCMs) in concrete has gained more attraction. Integration of PCM with building facades is a successful method to reduce energy consumption and improve human comfort. However, no single PCM can work in an all-weather scenario. Hence, in this research work, an attempt is made to select a suitable PCM for Chennai city, India, and this methodology can be employed at any geographical location. The PCM tile is designed by including certain features to increase the thermal conductivity of the PCM zone. The optimum design of the PCM tile is achieved through multi-objective optimization techniques. L27 orthogonal array is employed, and all the tests were conducted through validated numerical simulation. Redesigned PCM tile includes a PCM layer of 2 cm thickness with a 10% mix of copper nanoparticles covered by plaster. Redesigned PCM tile reduces the peak indoor temperature by 6.62℃ compared with conventional roof systems.
Enhancing physical education at the middle school level exploring three innovative teaching methods
Authors: Brenna Alyson , Deutsch Joe 
Published: October 2024

Times have evolved in the world of Physical Education (PE). The subject area has undergone significant changes, leaving behind the experiences of previous generations. The article explores the shifts in middle school PE, recognizing the challenges arising from decreased participation and motivation. Acknowledging the critical role of PE in shaping resilient, active, and self-motivated individuals, this article aims to help current PE teachers incorporate innovative teaching methods by giving some examples of how to do so. The article dives into three innovative teaching methods: gamification and technology integration, student-centered inquiry, and the flipped classroom. Gamification, combining play and technology into PE, catches students' attention and becomes an exciting journey. Student-centered inquiry allows learners to actively participate in their educational journey, encouraging exploration, critical thinking, and a genuine passion for physical activity. The flipped classroom strategy optimizes class time for physical activity by shifting content delivery outside the classroom. The impact of these innovative methods extends beyond traditional instructional approaches. They enhance student engagement and motivation, making PE relatable and enjoyable, which leads to increased participation and motivation. These helpful strategies encourage the development of essential life skills such as teamwork, critical thinking, and self-motivation, preparing students for challenges that go beyond the gymnasium.
Rationalising the Digital Public Sphere
Authors: Almuqren Abdullah 
Published: October 2024

This paper explores the suitability of Jürgen Habermas' concepts about the rationality of communicative actions in relation to the Internet and social media. The paper investigates the contemporary digital realm, analysing whether it functions as an expansion of the public sphere classic conceptualised by Habermas, with the aim of improving the level of rational communication. To accomplish this, the paper analyses the characteristics of the digital era, exploring Habermas's stance on social media and contemporary media. The paper analyses Habermas's concepts about the rationality of communication and supports the arguments with relevant literature to investigate the impact of current communication tools, including the Internet and its applications, on enhancing the quality of rational discourse. In order to accomplish this, it is important to thoroughly examine the key subjects pertaining to Habermas's philosophy of communication and assess its relevance to the modern virtual public sphere.
The Effects of Field-of-Education Job Mismatch on the Current Earnings of the Recent Graduates of the University of Gambia
Authors: Jaiteh Lala , Xin Gong , Sidibe Abou 
Published: October 2024

Access to decent and well-paid jobs is increasingly challenging for many college graduates. As a result, these graduates often turn to "nonstandard" employment, which is typically outside their field of study. This study examined the impact of field-of-education-job mismatch on the current earnings of recent graduates from the University of the Gambia. It specifically investigated how working in mismatched jobs has affected their earnings. The research focuses on the 2016-2019 cohort of graduates from the School of Arts, Sciences, and Humanities at the University of the Gambia. An explanatory sequential mixed-method design was used to examine the effects of field-of-education-job mismatch on these graduates. The quantitative phase consisted of three hundred (n=300) graduates who were selected through the use of simple random selection techniques, while the qualitative phase consisted of twenty (n=20) cases who were purposively selected from the quantitative phase based on the severity of the mismatch. The Chi-square analysis and multivariate linear regression analysis were used to ascertain the effects of field-of-education-job mismatch on the current earnings of the graduates. The results obtained from the quantitative phase revealed that the self-evaluation of participants who are currently working showed that more than half (56.4%) of the participants indicated that their field-of-study did not at all match with their current job. Only 13.3% indicated that their field of study perfectly matched their current job. The analysis showed one variable significantly related to current earnings (income) at p<0.05. However, two more variables (females and Ph.D. graduates) showed a significant relationship with current earnings among graduates at p<0.1.
A pilot metabolomics study across the continuum of interstitial lung disease fibrosis severity
Authors: Zhan Jiada , Jarrell Zachery R. , Hu Xin , Weinberg Jaclyn , Orr Michael , Marts Lucian , Jones Dean P. , Go Young‐Mi 
Published: October 2024

AbstractInterstitial lung diseases (ILDs) include a variety of inflammatory and fibrotic pulmonary conditions. This study employs high‐resolution metabolomics (HRM) to explore plasma metabolites and pathways across ILD phenotypes, including non‐fibrotic ILD, idiopathic pulmonary fibrosis (IPF), and non‐IPF fibrotic ILD. The study used 80 plasma samples for HRM, and involved linear trend and group‐wise analyses of metabolites altered in ILD phenotypes. We utilized limma one‐way ANOVA and mummichog algorithms to identify differences in metabolites and pathways across ILD groups. Then, we focused on metabolites within critical pathways, indicated by high pathway overlap sizes and low p‐values, for further analysis. Targeted HRM identified putrescine, hydroxyproline, prolyl‐hydroxyproline, aspartate, and glutamate with significant linear increases in more fibrotic ILD phenotypes, suggesting their role in ILD fibrogenesis. Untargeted HRM highlighted pathway alterations in lysine, vitamin D3, tyrosine, and urea cycle metabolism, all associated with pulmonary fibrosis. In addition, methylparaben level had a significantly increasing linear trend and was higher in the IPF than fibrotic and non‐ILD groups. This study highlights the importance of specific amino acids, metabolic pathways, and xenobiotics in the progression of pulmonary fibrosis.
An unusual case of twin anemia polycythemia sequence complicated by premature ductus arteriosus constriction of the recipient twin
Authors: Chokshi Ravi , McMullen Kathryn , Soni Shelly , Tunks Robert , O’Brien James 
Published: October 2024

Abstract

Objectives
To add to the nascent literature on twin anemia polycythemia sequence by presenting a unique cardiac complication in the recipient twin.

Case presentation
We describe a monochorionic diamniotic pregnancy complicated by twin anemia polycythemia sequence wherein the recipient twin developed signs of right heart failure secondary to premature ductus arteriosus constriction, requiring iatrogenic preterm delivery to avoid intrauterine demise.

Conclusions
This case report introduces a previously undescribed complication of twin anemia polycythemia sequence and adds to the growing literature on this clinical entity.
Patriarcapitalism? Towards an Intertwined History of Inheritance law and Capitalism from the Middle Ages to the Industrial Revolution (c. 1350–1850)
Authors: Campagne Armel 
Published: October 2024

Abstract
This article examines the patriarchal nature of inheritance law in late medieval and early modern England, the existence of an aristocratic offensive in the field of law against women’s inheritance rights between the 14th and the 18th century, and the relation between this offensive and the rise of agrarian capitalism. It then investigates the favorable effects of this legal legacy on the accumulation and concentration of the means of agrarian, coal and industrial commodity production in the hands of a minority of male aristocrats and bourgeois who played a significant role in the making of the Industrial Revolution.
Detection of morphine and data processing using surface plasmon resonance imaging sensor
Authors: Sun Jianuo , Ke Haokun , Wang Jinghan , Du Xianchao , Hao Hongxia , Zhou Hong 
Published: October 2024

Abstract
Based on the surface plasmon resonance imaging (SPRi) instrument, we established a new method of analyzing morphine in urine by processing a calibration curve. According to an inhibition immunoassay, gradient concentration of morphine and morphine-BSA fixed on the chip competitively combine with morphine antibody on the chip. Given the three mathematical models, the data of SPRi signals generated from SPRi with morphine was processed to obtain the calibration curve. Ultrafiltration was used to pretreat blank urine samples with adding morphine, and then investigated the advantages and disadvantages of each model. With a limit detection of 6.57 ng·mL−1, the method and mathematical models can provide robust support for SPRi sensors used in further environmental detection, such as the epidemiological study of sewage.
Patriarchal Restrictions and Maternal Manoeuvres: Igbo Women’s Quest for Land Inheritance Rights
Authors: Onyebueke Victor , Nwosu Bernard , Uwaezuoke Nonso , Juliet Akalemeaku Okwuchi , Nnamani Collins , Olumba Ezenwa E. 
Published: October 2024

Abstract
We examine the nature of maternal manoeuvres practised by Igbo women of Nigeria in negotiating access to resources under the traditional restrictive customary system and the contemporary plural legal framework. While extant feminist scholarship on African patriarchy often highlights discrimination and violations of women’s property rights, it rarely acknowledges the subtle strategies women use to navigate male-dominated societies, especially regarding land rights and inheritance. Among the Igbo, women have instrumentalized certain practices that uphold the patriarchal system for land access, inheritance, and succession. While employing a mix of socio-legal and discourse analysis and collaborative autoethnography, our study explores the traditional phase of silent politics of access, including practices like the female husband or woman-to-woman marriage, traditional single parenthood (nrachi), levirate marriage (nkuchi), and concubinage. We also delve into the modern phase, where women use Assisted Reproductive Technologies (ARTs), child adoption, litigation, and legal instruments for property access. Our findings show that despite patriarchal biases in land rights, women navigate and assert their resource access using both traditional and modern methods.
Zinc and copper effect mechanical cell adhesion properties of the amyloid precursor protein
Authors: August Alexander , Hartmann Sabrina , Schilling Sandra , Müller-Renno Christine , Begic Tarik , Pierik Antonio J. , Ziegler Christiane , Kins Stefan 
Published: October 2024

Abstract
The amyloid precursor protein (APP) can be modulated by the binding of copper and zinc ions. Both ions bind with low nanomolar affinities to both subdomains (E1 and E2) in the extracellular domain of APP. However, the impact of ion binding on structural and mechanical trans-dimerization properties is yet unclear. Using a bead aggregation assay (BAA), we found that zinc ions increase the dimerization of both subdomains, while copper promotes only dimerization of the E1 domain. In line with this, scanning force spectroscopy (SFS) analysis revealed an increase in APP adhesion force up to three-fold for copper and zinc. Interestingly, however, copper did not alter the separation length of APP dimers, whereas high zinc concentrations caused alterations in the structural features and a decrease of separation length. Together, our data provide clear differences in copper and zinc mediated APP trans-dimerization and indicate that zinc binding might favor a less flexible APP structure. This fact is of significant interest since changes in zinc and copper ion homeostasis are observed in Alzheimer’s disease (AD) and were reported to affect synaptic plasticity. Thus, modulation of APP trans-dimerization by copper and zinc could contribute to early synaptic instability in AD.
Nutritional guidance through digital media for glycemic control of women with gestational diabetes mellitus: a randomized clinical trial
Authors: Valença Marlene Carvalho Teixeira , França Marcelo Santucci , Mattar Rosiane , Dualib Patricia Medici , Sanchez Victor Hugo Saucedo , de Almeida-Pititto Bianca , Araujo Júnior Edward , Traina Evelyn 
Published: October 2024

Abstract

Objectives
To compare the effectiveness of outpatient nutritional guidance supplemented by digital media with exclusively standard outpatient nutritional guidance in pregnant women with gestational diabetes mellitus (GDM).

Methods
This was a randomized, patient-blinded clinical trial conducted at the Diabetes and Pregnancy outpatient clinic from February 2021 to January 2023. Pregnant women with GDM were randomly allocated into two groups: the control group received exclusively outpatient nutritional guidance, and the Intervention Group received outpatient nutritional guidance along with reminders via WhatsApp. Dietary intake (calories, carbohydrates, lipids, proteins, and fibers) was evaluated using 24 h dietary recalls. Glycemic control and the need for pharmacological treatment were also assessed.

Results
A total of 81 women were included, 34 allocated to the control group, and 47 to the intervention group. Patients were followed for a period of 4–8 weeks. Significant differences were observed in some points of glycemic control between the two groups over the follow-up period. There were no statistical differences in pharmacological therapy (p=0.498); 188 24 h dietary recall were conducted in the control group and 290 in the intervention group. A statistically significant increase in lipid intake was observed in the intervention group over the follow-up period compared to the control group (p<0.001). No changes in calorie intake, other macronutrients, or fiber consumption were noted.

Conclusions
Glycemic control was significantly improved with the addition of frequent text reminders about dietary choices, and a significant increase in lipid intake was seen in all women, more so in the reminder group.
Human foot cutaneous receptors function: clinical findings and prospects of using medical devices to stimulate mechanoreceptors in neurorehabilitation
Authors: Riabova Alexandra , Bekreneva Maria , Saveko Alina 
Published: October 2024

Abstract
The effectiveness of the support stimulation of the mechanoreceptors of the feet has been first shown in space medicine. In space flight during support withdrawal with non-use of postural muscle, this method is a countermeasure against sensorimotor disorders. Later, it was applied in clinical practice as treatment of motor disorders after stroke, in Parkinson’s disease, infantile cerebral palsy, neuropathies, and many others. The impact of such stimulation on motor control is due to spinal and supraspinal mechanisms, which are activated by creating an additional support afferent input through the plantar surface. Many studies confirmed the positive effect of support stimulation on motor control, but the protocols of such stimulation remain the subject of active discussion. This review includes (1) the features of sensitivity of the foot sole cutaneous afferents to the support mechanical stimuli, (2) data on spinal and supraspinal responses of the nervous system to support stimulation, and (3) the results of applying this approach in neurological practice via various techniques. Summarizing this information, the authors highlight the most promising ways and types of medical devices for foot support stimulation in neurology.
Cystatin C alleviates unconjugated bilirubin-induced neurotoxicity by promoting bilirubin clearance from neurocytes via exosomes, dependent on hepatocyte UGT1A1 activity
Authors: Du Yating , Li Zhenkun 
Published: October 2024

Abstract
There is an urgent need to identify effective drugs for the treatment of nerve injury caused by unconjugated bilirubin (UCB). Our previous research found that cystatin C (CST3) alleviates UCB-induced neurotoxicity by promoting autophagy in nerve cells, but that autophagy inhibitors did not completely inhibit the effects of CST3. This study investigated whether CST3 could alleviate the neurotoxicity of UCB by promoting the secretion and transport of exosomes containing UCB to the liver for metabolism. It demonstrated that hyperbilirubinemia mice treated with CST3 had a higher number of serum exosomes than those in hyperbilirubinemia mice treated with phosphate-buffered saline. CST3-mediated protection against UCB-induced damage was abolished when autophagy and extracellular vesicle inhibitors were used in combination. The number of exosomes in the CST3 overexpression group was higher than that in the control group. Molecular docking experiments showed that UCB and CST3 had high docking score (−8.2). These results suggest that UCB may be excreted from cells by exosomes, and CST3 may promote this process by binding to UCB and entering the exosomes. We demonstrated that the effect of CST3 relied on liver cells with normal UDP-glucuronyl transferase1A1 (UGT1A1) activity in a coculture system of HT22 and L02 cells. CST3 levels were lower in exosomes secreted by L02 cells than in those secreted by human umbilical vein endothelial cells (HUVECs), whereas CST3 levels were higher in the culture supernatants of L02 cells than in the culture supernatants of HUVECs. This suggests that UCB exosomes in L02 cells may be released and internalized by CST3 and that UCB is then processed by UGT1A1 to conjugate UCB, thus reducing its toxicity. These results suggest that CST3 might alleviate UCB-induced neurotoxicity by promoting the clearance of UCB from cells via exosomes and that these effects are dependent on UGT1A1 activity in liver cells.
Tensiones antropocéntricas en “La Vorágine” de José Eustasio Rivera
Authors: Duarte Arias Daniel Augusto 
Published: October 2024

La obra de José Eustasio Rivera, La Vorágine, ha suscitado diversas reflexiones y ha sido abordada desde múltiples perspectivas dentro de la literatura colombiana. Incluso su autor ha sido tema de debate en el entorno académico por su historia (cf. Peña Gutiérrez, 2024). En cuanto a la obra, Sol Peláez (2015) sostiene que La Vorágine representa una constante tensión entre diversos factores que conforman la identidad Nacional y Continental, que también pueden desmantelar dicha identidad. Una reflexión similar es la de Alfredo Duplat y Andrés Molina Ochoa (2020), quienes sugieren que esta obra ofrece una explicación sobre cómo nos constituimos y de nuestra identidad Nacional.
Monomorphic premature ventricular contractions in patients without cardiac structural changes: clinical and prognostic significance and evaluation of therapy effectiveness (clinical and experimental study)
Authors: Olesin A. I. , Konstantinova I. V. , Tyuteleva N. N. , Zueva Yu. S. , Ivanov V. S. , Koziy A. V. 
Published: October 2024

Aim. To determine the individualized choice of therapy for monomorphic premature ventricular contractions (PVCs) in patients without structural cardiac changes by assessing the predictors of arrhythmogenic cardiomyopathy (ACM) and the clinical and prognostic significance of its course.Material and methods. Experimental study. Animals were used to model PVCs by the mechanism of early post-depolarization (EPD) (aconitine), re-entry (peroxide or H2O2 arrhythmia). In addition to the generally accepted parameters, the following ACMs were analyzed during electrocardiography (ECG): pre-ectopic interval, its variability, maximum index of internal deviation of PVCs, the QRS complex of PVC (QRSpvc), QRS of sinus rhythm (QRSsr), their ratio (QRSpvc/QRSsr), etc. Clinical study. A total of 343 patients with class IV-V PVCs aged 16 to 34 years were observed (B. Rayn, 1984). The same parameters were determined by ECG as in experimental arrhythmias. The follow-up duration was up to 10 years. The end point was the detection or absence of cardiovascular pathology.Results. Experimental study. When modeling ventricular arrhythmias using the EPD mechanism, early (R/T) monotopic PVCs were recorded, and re-entry — early and late monomorphic PVCs. ACM predictors were recorded only when modeling arrhythmia by the re-entry mechanism. Clinical study. In patients without structural cardiac changes, early (R/T) monotopic PVC highly correlated with ventricular ectopy induced by the EPD mechanism (aconitine) (r=0,92). These patients did not have cardiovascular diseases, and the most effective antiarrhythmic drugs for eliminating ventricular ectopy were class I drugs. In patients without structural cardiac changes, early and late monomorphic PVCs highly correlated with experimental ventricular ectopy caused by the re-entry mechanism (H2O2 arrhythmia). In these patients, on average, 7,2±0,5 years after inclusion in the study, various clinical forms of coronary artery disease were detected, and the positive clinical effect of PVC treatment was achieved mainly with the use of class III antiarrhythmic drugs.Conclusion. In patients with early monotopic ventricular ectopia, without detection of ACM predictors, the most effective were class I antiarrhythmic drugs. In other patients with early and late monomorphic ventricular ectopia and detected ACM predictors, class III agents were found to be effective.