bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the molecular mechanisms of human diseases: the benefits of fission yeasts
Authors: Acs-Szabo Lajos , Papp Laszlo Attila , Miklos Ida 
Published: October 2024

Abstract
The role of model organisms such as yeasts in life science research is crucial. Although the baker’s yeast (Saccharomyces cerevisiae) is the most popular model among yeasts, the contribution of the fission yeasts (Schizosaccharomyces) to life science is also indisputable. Since both types of yeasts share several thousands of common orthologous genes with humans, they provide a simple research platform to investigate many fundamental molecular mechanisms and functions, thereby contributing to the understanding of the background of human diseases. In this review, we would like to highlight the many advantages of fission yeasts over budding yeasts. The usefulness of fission yeasts in virus research is shown as an example, presenting the most important research results related to the Human Immunodeficiency Virus Type 1 (HIV-1) Vpr protein. Besides, the potential role of fission yeasts in the study of prion biology is also discussed. Furthermore, we are keen to promote the uprising model yeast Schizosaccharomyces japonicus, which is a dimorphic species in the fission yeast genus. We propose the hyphal growth of S. japonicus as an unusual opportunity as a model to study the invadopodia of human cancer cells since the two seemingly different cell types can be compared along fundamental features. Here we also collect the latest laboratory protocols and bioinformatics tools for the fission yeasts to highlight the many possibilities available to the research community. In addition, we present several limiting factors that everyone should be aware of when working with yeast models.
Report of RILEM TC 281-CCC: insights into factors affecting the carbonation rate of concrete with SCMs revealed from data mining and machine learning approaches
Authors: Vollpracht A. , Gluth G. J. G. , Rogiers B. , Uwanuakwa I. D. , Phung Q. T. , Villagran Zaccardi Y. , Thiel C. , Vanoutrive H. , Etcheverry J. M. , Gruyaert E. , Kamali-Bernard S. , Kanellopoulos A. , Zhao Z. , Martins I. M. , Rathnarajan S. , De Belie N. 
Published: October 2024

AbstractThe RILEM TC 281–CCC ‘‘Carbonation of concrete with supplementary cementitious materials’’ conducted a study on the effects of supplementary cementitious materials (SCMs) on the carbonation rate of blended cement concretes and mortars. In this context, a comprehensive database has been established, consisting of 1044 concrete and mortar mixes with their associated carbonation depth data over time. The dataset comprises mix designs with a large variety of binders with up to 94% SCMs, collected from the literature as well as unpublished testing reports. The data includes chemical composition and physical properties of the raw materials, mix-designs, compressive strengths, curing and carbonation testing conditions. Natural carbonation was recorded for several years in many cases with both indoor and outdoor results. The database has been analysed to investigate the effects of binder composition and mix design, curing and preconditioning, and relative humidity on the carbonation rate. Furthermore, the accuracy of accelerated carbonation testing as well as possible correlations between compressive strength and carbonation resistance were evaluated. One approach to summerise the physical and chemical resistance in one parameter is the ratio of water content to content of carbonatable CaO (w/CaOreactive ratio). The analysis revealed that the w/CaOreactive ratio is a decisive factor for carbonation resistance, while curing and exposure conditions also influence carbonation. Under natural exposure conditions, the carbonation data exhibit significant variations. Nevertheless, probabilistic inference suggests that both accelerated and natural carbonation processes follow a square-root-of-time behavior, though accelerated and natural carbonation cannot be converted into each other without corrections. Additionally, a machine learning technique was employed to assess the influence of parameters governing the carbonation progress in concretes.
Short-term functional outcome of total hip arthroplasty for avascular necrosis of femoral head and influence of patient-related factors
Authors: Khoa V. Vu , Quang Nguyen , Lan T. P. Luong , Thieu Q. Nguyen , Loi B. Cao , Anh T. Le 
Published: October 2024

Introduction Avascular necrosis of the femoral head (ANFH) is a phenomenon vascular supply disruption lead to death of bone cells around the femoral head. The disease is a severe health issue all over the world. Within 2 years about 80 % to 85 % of symptomatic cases will result in collapse of the femoral head. Recovery of hip function after total hip arthroplasty (THA) may be influenced by many factors that vary among different racial/ethnic groups. Most findings in this field have been from Western developed nations, and not much information from developing Asian countries is available.This study aimed to determine the six-month functional outcome and patient–related factors that predict functional recovery in patients with avascular necrosis of the femoral head (ANFH) undertaking total hip arthroplasty (THA).Methods Between January 2022 and December 2023 there were 143 patients participating in this prospective study. Demographic, medical history and clinical findings were collected from their medical records. The six-month functional outcome was evaluated using the Harris hip score (HHS). The mean age of the participants was 55.90 ± 11.49 years, and the majority (86.7 %) were male. Most patients had excellent (43.4 %) or good outcome (51.7 %).Discussion Our study had some limitations: the length of the follow-up after surgery is short (6 months), that hospital-related factors like the type and volume of the hospital have not been analyzed. Nonetheless, previous observations suggest that most of the improvement in physical function occurs during the first six months following surgery and remains the same for a long time. However, our sample has typical demographic and clinical characteristics of patients with THA for ANFH, suggesting that determinants of the 6-month functional outcome in the current study could apply to other patients undergoing this surgery.Results The determinants of excellent outcome were a higher preoperative HHS (odds ratio (OR): 4.369, 95 % confidence interval (CI) =1.854 – 10.299; p < 0.001) and absence of comorbidity (OR: 2.440, 95 % CI = 1.071 – 5.557, p = 0.034). No demographic (age, gender, body mass index), medical history (using of steroids, alcohol consumption or smoking), or any other clinical parameter (stage or side of the affected hip, time until surgery) had a significant influence on functional outcome.Conclusion Earlier surgery during functional decline and better management of comorbidity may help improve THA outcomes for patients with avascular necrosis of the femoral head.
Antibacterial effect of semiconductor laser radiation against the strains of S. aureus and P. aeruginosa, leading pathogens in osteomyelitis
Authors: Shipitsyna I. V. , Spirkina E. S. 
Published: October 2024

Introduction The study of the antibacterial effect of photodynamic therapy against the leading pathogens of chronic osteomyelitis is one of the promising directions today.Purpose of the work was to evaluate the antibacterial effect against the strains of Staphylococcus aureus and Pseudomonas aeruginosa with the ALOD-01 laser system in the presence of photodithazine.Materials and methods The object of the study was 24-hour archival cultures of gram-positive and gram-negative microorganisms belonging to two taxa: Staphylococcus aureus (25923), Pseudomonas aeruginosa (27853). The antibacterial effect after the exposure to laser radiation in the presence of photodithazine on the microbial cells of the studied cultures was assessed by the absence of microorganism growth in the area of the light beam.Results Laser exposure in combination with photodithazine (concentration 0.5–1.0 mg/ml) on S. aureus for two minutes at 200–300 J achieved a bactericidal effect in the beam area. A bactericidal effect on the entire surface of the Petri dish was achieved with light exposure of 400 J for 5 minutes and a photodithazine concentration of 1.0 mg/ml. Laser exposure for 2 minutes in the presence of photodithazine at a concentration of 0.5 mg/ml and 1 mg/ml did not have an antibacterial effect on P. aeruginosa strains. Continuous growth of microorganisms was observed on the dish. Increasing the light dose and exposure time contributed to a decrease in the growth of microbial cells. A bactericidal effect was obtained only in the center of the dish in treating the bacterial suspension with photodithazine at a concentration of 5 mg/ml.Discussion The effectiveness of PDT depends on the type of microorganisms, the anatomical location of the infection site, as well as the properties of the photosensitizer and the laser used. Depending on the structure of the cell wall, different susceptibility of bacteria to photodynamic effects is observed.Conclusion S. aureus strains can be successfully photoinactivated using photodithazine. For P. aeruginosa strains, it was not possible to find a regime in which microbial cell growth was absent throughout the dish. The photodynamic reaction occurs only when adequate doses of light energy act on the photosentisizer in the presence of oxygen in the medium, while the photodynamic damage is local and the bactericidal effect is limited by the zone of light exposure.
The effect of zinc-containing calcium phosphate coating on the osseointegration of transcutaneous implants for limb prosthetics
Authors: Stogov M. V. , Emanov A. A. , Kuznetsov V. P. , Komarova E. G. , Gorbach E. N. , Kireeva E. A. , Tolkacheva T. V. , Sharkeev Yu. P. 
Published: October 2024

Introduction Increasing the integration of transcutaneous implants is an important goal for their application in clinical practice.The purpose of the work was to evaluate the osseointegration of transcutaneous titanium implants with calcium-phosphate coating containing zinc ions.Materials and methods The studies were performed on 12 male rabbits, who underwent implantation of an original implant into the tibial stump. After implantation, a compression device was installed on the bone, maintaining a load of 3.5 N for 5 weeks. Duration of observation was 26 weeks. The animals were divided into two groups: a control group (n = 6) with an implant without coating and an experimental group (n = 6) with a zinc-substituted calcium-phosphate coated implant.Results The implant fell out in one case in animals from the control group; no cases of implant loss were noted in the experimental group. It was revealed that the weight concentration of Ca and P in all zones of the bone-implant block of the animals in the experimental group significantly exceeded similar indicators in the control group. In the control group, long-term persistence of high levels of C-reactive protein was noted, which was not observed in the experimental group.Discussion This series of studies has shown that an implant with a zinc-modified calcium-phosphate coating exhibited a more effective integration, in contrast to an uncoated product. The absence of serious adverse reactions to the tested products indicates acceptable tolerability and safety of its use.Conclusion The implants with a zinc-modified calcium-phosphate coating showed signs of more effective osseointegration compared to the product without additional coating.
Surgical correction of posttraumatic triphalangeal joint flexion contractures of the fingers (systematic literature review)
Authors: Abdiba N. V. , Rodomanova L. A. , Afanasyev A. O. , Chizhov A. E. , Mironov A. R. , Romanov D. V. , Tsybul E. S. 
Published: October 2024

Introduction Triphalangeal joint flexion contracture of the fingers is a common and challeging posttraumatic hand condition. The goal of surgical treatment is to correct finger deformity and increase interphalangeal range of motion.The objective was to systematize data on the causes of post-traumatic triphalangeal joint flexion contracture of the fingers and methods of surgical correction.Material and methods The original literature search was conducted on key resources including Scientific Electronic Library (www.elibrary.ru), the National Library of Medicine (www.pubmed.org), ScienceDirect, Google Scholar, Ovid databases according to PRISMA recommendations. Literature searches included both Russian and English studies, with one or more cases of post-traumatic triphalangeal joint flexion contracture of the fingers with the deformity surgically corrected. Cases of non-traumatic flexion contractures were excluded. Etiological factors of flexion contractures, heterogeneity of definitions and methods for recording the range of motion in the joint, anatomical features, surgical correction of flexion contractures and postoperative complications were reviewed.Results Common causes of flexion contractures included burns (32.3 %), dislocations and fracturedislocations of the finger joints (23.5 %). The median postoperative follow-up period was 13.5 months after surgical treatment. Surgical correction was produced with external fixation device (EFD) in 40 % of cases, open procedures performed in 50 % and a combined technique employed in one case (10 %). Based on calculations of the odds ratios of postoperative complications, a weak positive linear relationship was revealed between EFD and pain syndrome, and a weak negative linear relationship was observed between the open procedure and pain.Discussion There is heterogeneity of approaches regarding methods for correcting flexion contractures, surgical approaches, techniques for mobilizing joints and releasing the anatomical structures of the finger with open procedures, the distraction rate with EFD, methods for repair of soft tissue defects following the treatment of flexion contractures of interphalangeal joint of a finger.Conclusion Open procedures are commonly used for precise elimination of all components of flexion contracture of the joint and repair of soft tissue defects of the finger. A weak positive linear relationship was revealed between EF and pain syndrome. There was no significant correlation between open techniques and complications. There were no correlations between the treatment method and the contracture type; there are no treatment regimens for patients with this pathology.
Optimizing revision arthroplasty: the role of customized articulating spacers
Authors: Minasov B. Sh. , Yakupov R. R. , Akbashev V. N. , Bilyalov A. R. , Minasov T. B. , Valeev M. M. , Mavlyutov T. R. , Karimov K. K. , Berdin A. R. 
Published: October 2024

Introduction The advancement of surgery is set against a backdrop of continuous development and surgical innovations have transformed the way clinical care is delivered. Revision surgery might be required to address complications of primary arthroplasty. The first stage of revision arthroplasty would involve removal of an implant and placement of an antibiotic-impregnated cement spacer to maintain the joint space and stability, prevent soft tissue retraction, provide local antibiotic release and preserve bone tissue for revision implantation at the final stage of revision. Custom-made articulating spacers are a promising tool for optimizing the first stage of revision arthroplasty.The objective was to summarize the current data and present comprehensive information about spacers used in two-stage revision arthroplasty including manufacturing techniques, physical and chemical properties, clinical applications, the possibility of customization within the first stage of revision arthroplasty, current and promising directions for research.Material and methods The original literature search was conducted on key resources including Scientific Electronic Library (www.elibrary.ru), the National Library of Medicine (www.pubmed.org), the Cochraine Library (www.cochranelibrary.com) between 2018 and 2023 using search words and phrases: total arthroplasty, complications, revision arthroplasty, articulating spacer, periprosthetic joint infection, additive manufacturing, 3D printing.Results A comparative analysis of factory supplied, home-made, dynamic and static spacer models showed that the choice of articulating spacers for revision arthroplasty of major joints is of great relevance. Advantages of factory-made spacers include standardized range of sizes, the reliability and availability for medical institutions. They are characterized by limited use in repair of severe bone defects.Discussion Custom-made articulating spacers enable specific tailoring to accommodate individual defects. Despite high expectations from custom-made spacers, development of optimal technologies for rapid prototyping is essential. Investments in research and development in this area have the potential to create innovative solutions that can significantly improve the results of revision arthroplasty.Conclusion The paper explores the importance of systemization of knowledge about spacers and the role of new research in improving the design and functionality. Progress in the field of materials science, additive technologies and a personalized approach to spacer manufacturing can expand possibilities of revision arthroplasty and the effectiveness. Personalized approaches and improved methods of local drug delivery that provide controlled release of antibiotics can improve the results of treatment of periprosthetic joint infections.
Mulheres pentecostais no Sertão da Bahia: orando e curando
Authors: Santos Elvia Cristina Silva , Silva Elizete da 
Published: October 2024

Analisamos a importância e o papel desempenhado pelas mulheres na expansão do Pentecostalismo assembleiano no Sertão da Bahia, principalmente, através do exercício de orações e da prática de cura para os diversos males, curas milagrosas, advindas do poder divino. Apesar do pastorado ter se posicionado contrário à ordenação feminina, argumento fundamentado a partir de uma leitura sexista da Bíblia, a hierarquia eclesiástica não abriu mão dos esforços femininos para a expansão evangelística, desde que não competissem com os homens e não ocupassem o sacerdócio, por ser considerado antiblíbico. Mas, as mulheres protagonizaram o pioneirismo da Assembleia de Deus em muitas regiões do Brasil, tal como aconteceu no interior baiano.
STRATEGI PENGUATAN DEMOKRASI AGONISTIK PADA BADAN EKSEKUTIF MAHASISWA DALAM PERSPEKTIF PENDIDIKAN KEWARGANEGARAAN (STUDI PADA BEM FKIP UNS)
Authors: Ismi Ismi , Rasyid Machmud Al , Yuliandari Erna 
Published: October 2024

Penelitian ini bertujuan untuk (1) Mendeskripsikan strategi untuk menguatkan demokrasi agonistik mahasiswa dalam lingkungan BEM FKIP UNS; (2) Mendeskripsikan hasil dari penguatan demokrasi agonistik terhadap kualitas demokrasi di lingkungan BEM FKIP UNS dalam perspektif Pendidikan Kewarganegaraan. Penelitian ini merupakan penelitian deskriptif kualitatif. Teknik pengumpulan data menggunakan wawancara mendalam, observasi, serta analisis dokumen. Pengambilan subjek penelitian menggunakan teknik <em>purposive sampling. </em>Lokasi penelitian pada BEM FKIP UNS Kabinet Alterasi 2023. Pengujian validitas data menggunakan triangulasi sumber dan triangulasi metode. Hasil penelitian yang didapatkan adalah sebagai berikut. <em>Pertama, </em>BEM FKIP UNS melaksanakan penguatan demokrasi agonistik melalui kegiatan yang diselenggarakan oleh organisasi tersebut seperti Rapat Harian Terbatas (RHT), pembinaan di masing-masing kementerian, LKMM-D, dan kegiatan kepanitiaan, bentuk penguatan yang dilakukan adalah dengan menciptakan kontestasi dan perdebatan yang sehat, menciptakan kebebasan dan kesetaraan dalam berpendapat, serta adanya kepastian terhadap pluralisme. <em>Kedua, </em>hasil dari penguatan demokrasi agonistik terhadap kualitas demokrasi di lingkungan BEM FKIP UNS yaitu dapat meningkatkan partisipasi aktif dari anggota dan pengurus organisasi, menumbuhkan kemampuan untuk mengelola konflik secara melembaga, dan mampu bersikap terbuka terhadap adanya perbedaan dan menjunjung tinggi nilai toleransi dimana hal ini menunjukkan adanya keterampilan kewarganegaran dan sikap kewarganegaraan dalam diri anggota dan pengurus BEM FKIP UNS.
The Food and Drug Administration’s Safety Surveillance of Adverse Event Cases Involving Cannabinoid Hemp Products, 2019–2023
Authors: Wolf Lisa , Hines Michelle , Ou Oliver , Wolpert Beverly , Nolan Nichole , Kenez Stephanie , Taylor Cassandra 
Published: October 2024

Objective. To characterize adverse event (AE) cases received by the US Food and Drug Administration (FDA) reportedly involving cannabinoid hemp products (CHPs). Methods. We searched the FDA Adverse Event Reporting System and Center for Food Safety and Applied Nutrition Adverse Event Reporting System for cases reported directly to the FDA from 2019–2023 involving CHPs, which are defined as products containing 1 or more of the following: cannabidiol, delta-8 tetrahydrocannabinol, and emerging cannabinoids (i.e., other intoxicating cannabinoids often synthesized from hemp-derived cannabidiol). We abstracted and summarized information on reporting trends, consumer demographics, reporter information, product information, and AEs. Results. We identified 610 AE cases reportedly involving CHPs containing 1 or more of the following: delta-8 tetrahydrocannabinol (n=355), cannabidiol (n=253), and emerging cannabinoids (n=36). Multiple trends and safety issues were identified, including an annual increase in the number of cases involving intoxicating cannabinoids since 2021, potential quality issues, and the occurrence of fatalities and pediatric exposures. Conclusions. Our findings emphasize the importance of monitoring AE cases received by the FDA involving CHPs as part of a comprehensive surveillance strategy to identify trends and safety issues with these products. ( Am J Public Health. 2024;114(S8):S664–S672. https://doi.org/10.2105/AJPH.2024.307712 )
Trends in Medical Encounters Involving Cannabis-Related Disorders Among US Medicare Beneficiaries, 2017–2022
Authors: Perez-Vilar Silvia , Kazemian Sara , Greene Christina , Duenas Pablo Freyria , Radin Rose , Lindaas Arnstein , Akhtar Sandia , Wernecke Michael , Chillarige Yoganand , Kelman Jeffrey A. , Graham David J. 
Published: October 2024

Objectives. To characterize cannabis-related disorder medical encounter trends in the US Medicare population during 2017 to 2022. Methods. We conducted a descriptive study, which included 56 624 432 beneficiaries aged 65 years or older and 10 247 953 aged 18 to 64 years with disability. All were continuously enrolled in Medicare (Fee-for-Service or Advantage) for 183 or more days before the first day of the calendar year. We identified cannabis-related disorder encounters using International Classification of Diseases, 10th Revision, Clinical Modification diagnosis codes and computed annual encounter rates per 10 000 beneficiaries. We used the Mann–Kendall test to analyze trends over time. Results. Annual cannabis-related disorder encounter trends among beneficiaries aged 65 years or older ranged from 15.9 (95% confidence interval [CI] = 15.8, 16.0) to 39.3 (95% CI = 39.1, 39.5) per 10 000. Rates among beneficiaries aged 18 to 64 years with disability ranged from 274.8 (95% CI = 273.6, 276.0) to 373.7 (95% CI = 372.3, 375.2) per 10 000. Rates increased over time across both groups, with average annual increases of 4.3 (95% CI = 3.3, 5.3; P = .01) and 17.1 (95% CI = 11.0, 23.2; P = .02) per 10 000, respectively. Conclusions. Further work is needed to explore the impact of coexisting medical conditions on outcomes that result from cannabis-related disorders. ( Am J Public Health. 2024;114(S8):S694–S697. https://doi.org/10.2105/AJPH.2024.307729 )