bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug Wars: Revolution, Embargo, and the Politics of Scarcity in Cuba, 1959–1964
Authors: LAMBE JENNIFER 
Published: October 2016

AbstractThe Cuban Revolution of 1959 ushered in many radical changes, both socio-economic and political. Yet the macropolitical upheaval of the period also manifested in concrete ways in the lives of ordinary Cubans. The sudden scarcity of everyday medications, closely linked to diplomatic tensions with the United States, was one such outcome. This article traces the transnational battles provoked by the sudden disappearance of US prescription drugs from Cuban shelves. It seeks to understand pharmaceutical shortages not only as a political side effect but also as a social reality, which provided a venue for the articulation of new forms of sociability and body politics.
Precuneus functioning differentiates first-episode psychosis patients during the fantasy movie Alice in Wonderland
Authors: Rikandi E. , Pamilo S. , Mäntylä T. , Suvisaari J. , Kieseppä T. , Hari R. , Seppä M. , Raij T. T. 
Published: October 2016

BackgroundWhile group-level functional alterations have been identified in many brain regions of psychotic patients, multivariate machine-learning methods provide a tool to test whether some of such alterations could be used to differentiate an individual patient. Earlier machine-learning studies have focused on data collected from chronic patients during rest or simple tasks. We set out to unravel brain activation patterns during naturalistic stimulation in first-episode psychosis (FEP).MethodWe recorded brain activity from 46 FEP patients and 32 control subjects viewing scenes from the fantasy film Alice in Wonderland. Scenes with varying degrees of fantasy were selected based on the distortion of the ‘sense of reality’ in psychosis. After cleaning the data with a novel maxCorr method, we used machine learning to classify patients and healthy control subjects on the basis of voxel- and time-point patterns.ResultsMost (136/194) of the voxels that best classified the groups were clustered in a bilateral region of the precuneus. Classification accuracies were up to 79.5% (p = 5.69 × 10−8), and correct classification was more likely the higher the patient's positive-symptom score. Precuneus functioning was related to the fantasy content of the movie, and the relationship was stronger in control subjects than patients.ConclusionsThese findings are the first to show abnormalities in precuneus functioning during naturalistic information processing in FEP patients. Correlational findings suggest that these alterations are associated with positive psychotic symptoms and processing of fantasy. The results may provide new insights into the neuronal basis of reality distortion in psychosis.
Social support as a mediator variable of the relationship between depression and life satisfaction in a sample of Saudi caregivers of patients with Alzheimer's disease
Authors: Khusaifan Shatha Jamil , El Keshky Mogeda El Sayed 
Published: October 2016

ABSTRACTBackground:Caring for someone with Alzheimer's disease (AD) is very challenging. Social support may play a crucial role in helping caregivers to adapt better to their caregiving role. The aim of this study is to explore the role of social support as a moderator variable of the relationship between depression and life satisfaction in caregivers for patients with AD in Saudi Arabia.Methods:In this cross-sectional study, 122 caregivers for patients with AD completed questionnaires assessing informal social support, depressive symptoms, and general life satisfaction.Results:The demographic characteristics showed that 79% (n = 96) of caregivers were females and between the ages of 20 and 50. Higher levels of social support positively correlated with reported higher levels of life satisfaction (r = 0.483, p < 0.001). Depression was negatively correlated with social support (r = −0.418, p < 0.001) and life satisfaction scores (r = −0.553, p = < 0.001). Social support was found to be a partial mediator variable, mediating approximately 23.05% of the total effect of depression on life satisfaction (Sobel = −3.065, p = 0.002).Conclusion:Informal social support can act as a mediator variable in the relationship of depression and life satisfaction in caregivers of AD patients. Improving the informal social support networks may help in coping with caregiving burden and better quality of life.
Relationship of Lutein and Zeaxanthin Levels to Neurocognitive Functioning: An fMRI Study of Older Adults
Authors: Lindbergh Cutter A. , Mewborn Catherine M. , Hammond Billy R. , Renzi-Hammond Lisa M. , Curran-Celentano Joanne M. , Miller L. Stephen 
Published: October 2016

AbstractObjectives:It is well known that the carotenoids lutein (L) and zeaxanthin (Z) improve eye health and an accumulating evidence base suggests cognitive benefits as well. The present study investigated underlying neural mechanisms using functional magnetic resonance imaging (fMRI). It was hypothesized that lower L and Z concentrations would be associated with neurobiological inefficiency (i.e., increased activation) during cognitive performance.Methods:Forty-three community-dwelling older adults (mean age=72 years; 58% female; 100% Caucasian) were asked to learn and recall pairs of unrelated words in an fMRI-adapted paradigm. L and Z levels were measured in retina (macular pigment optical density) and serum using validated procedures.Results:Following first-level contrasts of encoding and retrieval trials minus control trials (p<.05, family-wise error corrected, minimum voxel cluster=8), L and Z were found to significantly and negatively relate to blood-oxygen-level-dependent signal in central and parietal operculum cortex, inferior frontal gyrus, supramarginal gyrus, planum polare, frontal and middle temporal gyrus, superior parietal lobule, postcentral gyrus, precentral gyrus, occipital cortex bilaterally, and cerebellar regions.Conclusions:To the authors’ knowledge, the present study represents the first attempt to investigate neural mechanisms underlying the relation of L and Z to cognition using fMRI. The observed results suggest that L and Z promote cognitive functioning in old age by enhancing neural efficiency. (JINS, 2017,23, 11–22)
Form does not follow function, but variation does: the origin and early usage of possessive havegot in English
Authors: LORENZ DAVID 
Published: October 2016

This article investigates the emergence and early use of possessive havegot in English. Two hypotheses about its emergence are tested on historical data (c.1460–1760). One hypothesis is based on communicative functionality, suggesting that got was inserted as a ‘pattern preserver’ to compensate for the increased reduction of have. The other hypothesis invokes the conventionalization of an invited inference, thus a (non-functional) semantic shift which does not immediately serve to support a communicative function. The diachronic evidence is found to support only the latter hypothesis.In the second part the early stage of the variation of have and havegot is investigated (c.1720–50). The results show a strong register difference, but also a division of labour between the variants that can be explained by the syntactic and semantic properties of havegot as having emerged out of a present perfect of get. Thus, the variation is organized in a functionally motivated way.It is concluded that in the development of possessive havegot functional constraints apply to the variation early on, but do not play an evident role in the emergence of the new variant. This suggests that functional motivations are a directing force but not necessarily a driving force in language change.
Kant as Both Conceptualist and Nonconceptualist
Authors: Golob Sacha 
Published: October 2016

AbstractThis article advances a new account of Kant’s views on conceptualism. On the one hand, I argue that Kant was a nonconceptualist. On the other hand, my approach accommodates many motivations underlying the conceptualist reading of his work: for example, it is fully compatible with the success of the Transcendental Deduction. I motivate my view by providing a new analysis of both Kant’s theory of perception and of the role of categorical synthesis: I look in particular at the categories of quantity. Locating my interpretation in relation to recent research by Allais, Ginsborg, Tolley and others, I argue that it offers an attractive compromise on this important theoretical and exegetical issue.
‘Total Transformation’: Why Kant Did Not Give up on Education
Authors: Louden Robert B. 
Published: October 2016

AbstractIn this essay I argue that Kant remained committed to the necessity and fundamental importance of education throughout his career. Like Johann Bernhard Basedow (1724–90), Kant holds that a ‘total transformation’ of schools is necessary, and he holds this view not only in the 1770s but in his later years as well. In building my case I try to refute two recent opposing interpretations – Reinhard Brandt’s position that Kant’s early ‘education enthusiasm’ was later replaced by a politics enthusiasm, and Manfred Kuehn’s view that the increasing importance of autonomy in Kant’s mature ethics leads him to de-emphasize education.
The Asymmetry of Space: Kant’s Theory of Absolute Space in 1768
Authors: Rukgaber Matthew S. 
Published: October 2016

AbstractI propose that we interpret Kant’s argument from incongruent counterparts in the 1768 article ‘Concerning the Ultimate Ground of the Differentiation of Directions in Space’ in light of a theory of dynamic absolute space that he accepted throughout the 1750s and 1760s. This force-based or material conception of space was not an unusual interpretation of the Newtonian notion of absolute space. Nevertheless, commentators have continually argued that Kant’s argument is an utter failure that shifts from the metaphysics of space to its epistemology, because he has no way to connect ‘directionality’ and ‘handedness’ to absolute space. This supposed failure is based on an understanding of absolute space in purely mathematical terms and as an absolute void that lacks any qualitative or dynamic features. If we recognize that Kant held that space had an intrinsic directional asymmetry then his argument successfully connects incongruent counterparts to absolute space. The presence of this notion in Kant’s pre-Critical thought is rarely noted, and its necessity in understanding his incongruence argument is novel.
Empirical Cognition in the Transcendental Deduction: Kant’s Starting Point and his Humean Problem
Authors: Sommerlatte Curtis 
Published: October 2016

AbstractIn this article, I argue that in the sense of greatest epistemological concern for Kant, empirical cognition is ‘rational sensory discrimination’: the identification or differentiation of sensory objects from each other (whether correctly or not), occurring through a capacity of forming judgements (whether correct or not). With this account of empirical cognition, I show how the Transcendental Deduction of the firstCritiqueis most plausibly read as having as its fundamental assumption the thesis that we have empirical cognition, and I provide evidence that Kant understood Hume as granting this assumption.
SOME INFINITE PERMUTATION GROUPS AND RELATED FINITE LINEAR GROUPS
Authors: NEUMANN PETER M. , PRAEGER CHERYL E. , SMITH SIMON M. 
Published: October 2016

This article began as a study of the structure of infinite permutation groups $G$ in which point stabilisers are finite and all infinite normal subgroups are transitive. That led to two variations. One is the generalisation in which point stabilisers are merely assumed to satisfy min-n, the minimal condition on normal subgroups. The groups $G$ are then of two kinds. Either they have a maximal finite normal subgroup, modulo which they have either one or two minimal nontrivial normal subgroups, or they have a regular normal subgroup $M$ which is a divisible abelian $p$-group of finite rank. In the latter case the point stabilisers are finite and act irreducibly on a $p$-adic vector space associated with $M$. This leads to our second variation, which is a study of the finite linear groups that can arise.
REPRESENTING CONJUNCTIVE DEDUCTIONS BY DISJUNCTIVE DEDUCTIONS
Authors: DOŠEN KOSTA , PETRIĆ ZORAN 
Published: October 2016

AbstractA skeleton of the category with finite coproducts${\cal D}$ freely generated by a single object has a subcategory isomorphic to a skeleton of the category with finite products ${\cal C}$ freely generated by a countable set of objects. As a consequence, we obtain that ${\cal D}$ has a subcategory equivalent with ${\cal C}$. From a proof-theoretical point of view, this means that up to some identifications of formulae the deductions of pure conjunctive logic with a countable set of propositional letters can be represented by deductions in pure disjunctive logic with just one propositional letter. By taking opposite categories, one can replace coproduct by product, i.e., disjunction by conjunction, and the other way round, to obtain the dual results.
25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
Authors: Jang Jiho , Park Sangjun , Jin Hur Hye , Cho Hyun-Ju , Hwang Inhwa , Pyo Kang Yun , Im Isak , Lee Hyunji , Lee Eunju , Yang Wonsuk , Kang Hoon-Chul , Won Kwon Sung , Yu Je-Wook , Kim Dong-Wook 
Published: October 2016

AbstractX-linked adrenoleukodystrophy (X-ALD), caused by an ABCD1 mutation, is a progressive neurodegenerative disorder associated with the accumulation of very long-chain fatty acids (VLCFA). Cerebral inflammatory demyelination is the major feature of childhood cerebral ALD (CCALD), the most severe form of ALD, but its underlying mechanism remains poorly understood. Here, we identify the aberrant production of cholesterol 25-hydroxylase (CH25H) and 25-hydroxycholesterol (25-HC) in the cellular context of CCALD based on the analysis of ALD patient-derived induced pluripotent stem cells and ex vivo fibroblasts. Intriguingly, 25-HC, but not VLCFA, promotes robust NLRP3 inflammasome assembly and activation via potassium efflux-, mitochondrial reactive oxygen species (ROS)- and liver X receptor (LXR)-mediated pathways. Furthermore, stereotaxic injection of 25-HC into the corpus callosum of mouse brains induces microglial recruitment, interleukin-1β production, and oligodendrocyte cell death in an NLRP3 inflammasome-dependent manner. Collectively, our results indicate that 25-HC mediates the neuroinflammation of X-ALD via activation of the NLRP3 inflammasome.
Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
Authors: Ulland Tyler K. , Jain Nidhi , Hornick Emma E. , Elliott Eric I. , Clay Gwendolyn M. , Sadler Jeffrey J. , Mills Kathleen A. M. , Janowski Ann M. , Volk A. Paige Davis , Wang Kai , Legge Kevin L. , Gakhar Lokesh , Bourdi Mohammed , Ferguson Polly J. , Wilson Mary E. , Cassel Suzanne L. , Sutterwala Fayyaz S. 
Published: October 2016

AbstractThe inbred mouse strain C57BL/6J is widely used in models of immunological and infectious diseases. Here we show that C57BL/6J mice have a defect in neutrophil recruitment to a range of inflammatory stimuli compared with the related C57BL/6N substrain. This immune perturbation is associated with a missense mutation in Nlrp12 in C57BL/6J mice. Both C57BL/6J and NLRP12-deficient mice have increased susceptibility to bacterial infection that correlates with defective neutrophil migration. C57BL/6J and NLRP12-deficient macrophages have impaired CXCL1 production and the neutrophil defect observed in C57BL/6J and NLRP12-deficient mice is rescued by restoration of macrophage NLRP12. These results demonstrate that C57BL/6J mice have a functional defect in NLRP12 and that macrophages require NLRP12 expression for effective recruitment of neutrophils to inflammatory sites.
Surface uplift in the Central Andes driven by growth of the Altiplano Puna Magma Body
Authors: Perkins Jonathan P. , Ward Kevin M. , de Silva Shanaka L. , Zandt George , Beck Susan L. , Finnegan Noah J. 
Published: October 2016

AbstractThe Altiplano-Puna Magma Body (APMB) in the Central Andes is the largest imaged magma reservoir on Earth, and is located within the second highest orogenic plateau on Earth, the Altiplano-Puna. Although the APMB is a first-order geologic feature similar to the Sierra Nevada batholith, its role in the surface uplift history of the Central Andes remains uncertain. Here we show that a long-wavelength topographic dome overlies the seismically measured extent of the APMB, and gravity data suggest that the uplift is isostatically compensated. Isostatic modelling of the magmatic contribution to dome growth yields melt volumes comparable to those estimated from tomography, and suggests that the APMB growth rate exceeds the peak Cretaceous magmatic flare-up in the Sierran batholith. Our analysis reveals that magmatic addition may provide a contribution to surface uplift on par with lithospheric removal, and illustrates that surface topography may help constrain the magnitude of pluton-scale melt production.
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events
Authors: Ashouri Arghavan , Sayin Volkan I. , Van den Eynden Jimmy , Singh Simranjit X. , Papagiannakopoulos Thales , Larsson Erik 
Published: October 2016

AbstractThousands of long non-coding RNAs (lncRNAs) lie interspersed with coding genes across the genome, and a small subset has been implicated as downstream effectors in oncogenic pathways. Here we make use of transcriptome and exome sequencing data from thousands of tumours across 19 cancer types, to identify lncRNAs that are induced or repressed in relation to somatic mutations in key oncogenic driver genes. Our screen confirms known coding and non-coding effectors and also associates many new lncRNAs to relevant pathways. The associations are often highly reproducible across cancer types, and while many lncRNAs are co-expressed with their protein-coding hosts or neighbours, some are intergenic and independent. We highlight lncRNAs with possible functions downstream of the tumour suppressor TP53 and the master antioxidant transcription factor NFE2L2. Our study provides a comprehensive overview of lncRNA transcriptional alterations in relation to key driver mutational events in human cancers.
The role of fivefold symmetry in suppressing crystallization
Authors: Taffs Jade , Patrick Royall C. 
Published: October 2016

AbstractAlthough long assumed to have an important role in the suppression of crystallization and the development of glassformers, the effect of local fivefold symmetry has never been directly tested. Here we consider whether such suppression of crystallization has a kinetic or thermodynamic nature and investigate its mechanism. We introduce a model in which the degree of fivefold symmetry can be tuned by favouring arrangements of particles in pentagonal bipyramids. We thus show that fivefold symmetry has both kinetic and thermodynamic effects on the mechanism of crystallization to a face-centred cubic crystal. Our results suggest that the mechanism of crystallization suppression is related to the surface tension between fluid and crystal. Interestingly, the degree of fivefold symmetry has little effect on crystal growth rate, suggesting that growth may be only weakly coupled to fluid structure in hard sphere like systems. Upon increasing the fivefold symmetry, we find a first-order transition to an alternative icosahedra-rich phase. At intermediate bias strengths we find a one-component glassformer.
Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation
Authors: Kass Elizabeth M. , Lim Pei Xin , Helgadottir Hildur R. , Moynahan Mary Ellen , Jasin Maria 
Published: October 2016

AbstractThe mammary gland undergoes significant proliferative stages after birth, but little is known about how the developmental changes impact DNA double-strand break (DSB) repair. Mutations in multiple genes involved in homology-directed repair (HDR), considered a particularly accurate pathway for repairing DSBs, are linked to breast cancer susceptibility, including BRCA2. Using reporter mice that express an inducible endonuclease, we find that HDR is particularly robust in mammary tissue during puberty and pregnancy, accounting for 34–40% of detected repair events, more than in other tissues examined. Brca2 hypomorphic mutation leads to HDR defects in mammary epithelium during puberty and pregnancy, including in different epithelial lineages. Notably, a similar dependence on Brca2 is observed in other proliferative tissues, including small intestine epithelium. Our results suggest that the greater reliance on HDR in the proliferating mammary gland, rather than a specific dependence on BRCA2, may increase its susceptibility to tumorigenesis incurred by BRCA2 mutation.
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
Authors: Xie Min , Yu Yan , Kang Rui , Zhu Shan , Yang Liangchun , Zeng Ling , Sun Xiaofang , Yang Minghua , Billiar Timothy R. , Wang Haichao , Cao Lizhi , Jiang Jianxin , Tang Daolin 
Published: October 2016

AbstractSepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, the precise mechanism by which metabolic reprogramming regulates the inflammatory response is unclear. Here we show that aerobic glycolysis contributes to sepsis by modulating inflammasome activation in macrophages. PKM2-mediated glycolysis promotes inflammasome activation by modulating EIF2AK2 phosphorylation in macrophages. Pharmacological and genetic inhibition of PKM2 or EIF2AK2 attenuates NLRP3 and AIM2 inflammasomes activation, and consequently suppresses the release of IL-1β, IL-18 and HMGB1 by macrophages. Pharmacological inhibition of the PKM2–EIF2AK2 pathway protects mice from lethal endotoxemia and polymicrobial sepsis. Moreover, conditional knockout of PKM2 in myeloid cells protects mice from septic death induced by NLRP3 and AIM2 inflammasome activation. These findings define an important role of PKM2 in immunometabolism and guide future development of therapeutic strategies to treat sepsis.
Form, shape and function: segmented blood flow in the choriocapillaris
Authors: Zouache M. A. , Eames I. , Klettner C. A. , Luthert P. J. 
Published: October 2016

AbstractThe development of fluid transport systems was a key event in the evolution of animals and plants. While within vertebrates branched geometries predominate, the choriocapillaris, which is the microvascular bed that is responsible for the maintenance of the outer retina, has evolved a planar topology. Here we examine the flow and mass transfer properties associated with this unusual geometry. We show that as a result of the form of the choriocapillaris, the blood flow is decomposed into a tessellation of functional vascular segments of various shapes delineated by separation surfaces across which there is no flow, and in the vicinity of which the transport of passive substances is diffusion-limited. The shape of each functional segment is determined by the distribution of arterioles and venules and their respective relative flow rates. We also show that, remarkably, the mass exchange with the outer retina is a function of the shape of each functional segment. In addition to introducing a novel framework in which the structure and function of the metabolite delivery system to the outer retina may be investigated in health and disease, the present work provides a general characterisation of the flow and transfers in multipole Hele-Shaw configurations.