bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muscarinic receptor regulates extracellular signal regulated kinase by two modes of arrestin binding
Authors: Jung Seung-Ryoung , Kushmerick Christopher , Seo Jong Bae , Koh Duk-Su , Hille Bertil 
Published: June 2017

Significance
G-protein–coupled receptors (GPCRs) can transmit external signals into the cytoplasm via the activation of G proteins. They also mediate G-protein–independent signaling that uses arrestin to activate an extracellular signal-regulated kinase (ERK) cascade. Using real-time optical measurements, we show that arrestin binds in two modes. Stable binding of arrestin to phosphorylated amino acids in the third intracellular loop of the muscarinic receptor upregulates ERK. Transient binding of arrestin to the unphosphorylated receptor downregulates ERK. Thus, the signaling bias of ERK can be determined by binding modes of arrestin to the receptors. Our results suggest a molecular mechanism for GPCR-arrestin-ERK coupling and pave the way for the development of new therapeutic approaches.
Free will beliefs predict attitudes toward unethical behavior and criminal punishment
Authors: Martin Nathan D. , Rigoni Davide , Vohs Kathleen D. 
Published: June 2017

Significance
Understanding the bases of moral judgment has been a longstanding goal of social science. Factors undergirding morality are argued to be both globally uniform and regionally variable. The current study found evidence of both. For residents of countries with low levels of corruption and transparent systems of governance, free will beliefs predicted greater support for harsh criminal punishment and an intolerance of unethical behavior. For residents of countries beset with corruption and obfuscation, free will beliefs predicted greater support for criminal punishment but were decoupled from judgments of unethical behavior. These findings confirm causal conclusions from experimental research about the influence of free will beliefs on moral judgments and demonstrate variation by sociopolitical context.
Pathogen exploitation of an abscisic acid- and jasmonate-inducible MAPK phosphatase and its interception by
Arabidopsis
immunity
Authors: Mine Akira , Berens Matthias L. , Nobori Tatsuya , Anver Shajahan , Fukumoto Kaori , Winkelmüller Thomas M. , Takeda Atsushi , Becker Dieter , Tsuda Kenichi 
Published: June 2017

Significance
Pathogens cause disease by deploying virulence effectors that interfere with various host targets, whereas plants counteract pathogen virulence when invoking a potent immunity known as effector-triggered immunity (ETI). Little is known about the mechanism underlying this molecular battle between plant immunity and pathogen virulence. We find that the phytohormones abscisic acid and jasmonate (JA), the signaling pathways of which are often exploited by pathogens, transcriptionally activate a common family of protein phosphatases that suppress immune-associated MAP kinases. We demonstrate that a bacterial pathogen exploits the JA-mediated suppression of MAP kinases by using a JA-mimic, whereas ETI blocks JA signaling to counteract this bacterial virulence. Our results highlight suppression and protection of MAP kinases as a molecular battle between pathogens and plants.
Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins
Authors: Ali Moustafa R. K. , Wu Yue , Tang Yan , Xiao Haopeng , Chen Kuangcai , Han Tiegang , Fang Ning , Wu Ronghu , El-Sayed Mostafa A. 
Published: June 2017

Significance
Metastasis is the primary cause of cancer-related deaths. Current clinical treatments for antimetastasis, however, are not effective. This work aims to develop a strategy to inhibit cancer cell migration using gold nanorods (AuNRs) with systematic understanding of the mechanism. The ability of targeting AuNRs to cancer cell surface integrins and the introduction of NIR light to generate a mild plasmonic photothermal effect caused broad regulation on cytoskeletal proteins, thus impairing cancer cell migration. This strategy provides a potential application for controlling cancer metastasis.
Phosphosite charge rather than shootward localization determines OCTOPUS activity in root protophloem
Authors: Breda Alice S. , Hazak Ora , Hardtke Christian S. 
Published: June 2017

SignificanceThe evolution of plant vasculature was a key event in earth history because it enabled plants to effectively colonize land. The phloem vasculature was particularly important in this process. In angiosperms, the dominant group of extant terrestrial plants, phloem is assembled from specific conductive cells, the sieve elements. Here we provide evidence that a master regulator of the commitment to sieve element fate inArabidopsisis strongly conserved and already present in the most basal extant angiosperms. We demonstrate the exquisite dosage-sensitive action of this polar-localized protein and show that its activity is in part regulated through the charge in a phosphorylation site. Surprisingly, however, its shootward polar localization does not appear to be essential for its function.
Photoacoustic trace detection of gases at the parts-per-quadrillion level with a moving optical grating
Authors: Xiong Lian , Bai Wenyu , Chen Feifei , Zhao Xian , Yu Fapeng , Diebold Gerald J. 
Published: June 2017

Significance
The photoacoustic effect refers to the generation of sound through a process of optical heat deposition followed by thermal expansion, resulting in a local pressure increase that produces outgoing acoustic waves. In the linear acoustic regime, a unique property of the photoacoustic effect in a geometry with symmetry in one dimension is that when the optical source moves at the speed of sound, the amplitude of the acoustic wave increases linearly in time without bound. Here, the application of this effect to trace gas detection is described, using an optical grating that moves at the sound speed inside of a resonator equipped with a resonant piezoelectric crystal detector, yielding detection limits in the parts-per-quadrillion range.
Early phonology revealed by international adoptees' birth language retention
Authors: Choi Jiyoun , Broersma Mirjam , Cutler Anne 
Published: June 2017

SignificanceDutch adults who, as international adoptees, had heard Korean early in life but had forgotten it learned to identify an unfamiliar three-way Korean consonant distinction significantly faster than controls without such experience. Even adoptees who had been adopted at 3–5 mo of age showed the learning advantage. Thus, early exposure to spoken language, even in the first half-year of life, leaves traces that can facilitate later relearning. Before 6 mo, infants often discriminate foreign-language phonological contrasts better than adults can. This has been widely held to mean that infants younger than 6 mo have no native-language phonological knowledge to capture spoken input. Our findings are significant because they indicate that phonological knowledge is indeed in place before age 6 mo.
Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules
Authors: Blázquez-Moreno Alfonso , Park Soohyung , Im Wonpil , Call Melissa J. , Call Matthew E. , Reyburn Hugh T. 
Published: June 2017

Significance
Many activating immunoreceptors associate, via interactions between transmembrane domains, with adaptor molecules that mediate signaling for leukocyte activation. To date, the best characterized form of receptor complex assembly depends on a single basic transmembrane (TM) domain residue. We now describe a second, completely different solution for TM-mediated receptor assembly, found in three different Fc receptor TM domains, and involving a more complex polar/aromatic interface. Residues in the core of this interaction motif can also regulate receptor protein turnover. Thus, multiple solutions for TM-mediated receptor assembly with signaling modules have evolved. These findings may provide more broadly useful insights into how other immune receptors that do not contain charged residues in their TM domains assemble into complexes with signaling adaptor molecules.
Materials and processing approaches for foundry-compatible transient electronics
Authors: Chang Jan-Kai , Fang Hui , Bower Christopher A. , Song Enming , Yu Xinge , Rogers John A. 
Published: June 2017

Significance
Bioresorbable electronic systems have the potential to create important new categories of technologies, ranging from temporary biomedical implants to environmentally benign, green consumer devices. The results presented here provide a collection of ideas that establish the foundations for a realistic technology of this type, in which state-of-the-art silicon complementary metal-oxide-semiconductor foundries serve as the source of microscale, water-soluble electronic components configured for rapid assembly and electrical interconnection on soft, biocompatible polymer substrates. Demonstrations in various high-performance electronic systems illustrate the concepts, and fundamental studies establish the chemical kinetics and end products of dissolution in aqueous environments.
Thermokinetic Simulation of Precipitation in NiTi Shape Memory Alloys
Authors: Cirstea C D , Karadeniz-Povoden E , Kozeschnik E , Lungu M , Lang P , Balagurov A , Cirstea V 
Published: June 2017

AbstractConsidering classical nucleation theory and evolution equations for the growth and composition change of precipitates, we simulate the evolution of the precipitates structure in the classical stages of nucleation, growth and coarsening using the solid-state transformation Matcalc software. The formation of Ni3Ti, Ni4Ti3or Ni3Ti2precipitate is the key to hardening phenomenon of the alloys, which depends on the nickel solubility in the bulk alloys. The microstructural evolution of metastable Ni4Ti3and Ni3Ti2precipitates in Ni-rich TiNi alloys is simulated by computational thermokinetics, based on thermodynamic and diffusion databases. The simulated precipitate phase fractions are compared with experimental data.
GPU-powered model analysis with PySB/cupSODA
Authors: Harris Leonard A , Nobile Marco S , Pino James C , Lubbock Alexander L R , Besozzi Daniela , Mauri Giancarlo , Cazzaniga Paolo , Lopez Carlos F 
Published: June 2017

Abstract

Summary
A major barrier to the practical utilization of large, complex models of biochemical systems is the lack of open-source computational tools to evaluate model behaviors over high-dimensional parameter spaces. This is due to the high computational expense of performing thousands to millions of model simulations required for statistical analysis. To address this need, we have implemented a user-friendly interface between cupSODA, a GPU-powered kinetic simulator, and PySB, a Python-based modeling and simulation framework. For three example models of varying size, we show that for large numbers of simulations PySB/cupSODA achieves order-of-magnitude speedups relative to a CPU-based ordinary differential equation integrator.

Availability and implementation
The PySB/cupSODA interface has been integrated into the PySB modeling framework (version 1.4.0), which can be installed from the Python Package Index (PyPI) using a Python package manager such as pip. cupSODA source code and precompiled binaries (Linux, Mac OS/X, Windows) are available at github.com/aresio/cupSODA (requires an Nvidia GPU; developer.nvidia.com/cuda-gpus). Additional information about PySB is available at pysb.org.

Supplementary information
Supplementary data are available at Bioinformatics online.
Association between workarounds and medication administration errors in bar-code-assisted medication administration in hospitals
Authors: van der Veen Willem , van den Bemt Patricia MLA , Wouters Hans , Bates David W , Twisk Jos WR , de Gier Johan J , Taxis Katja ,   for the BCMA Study Group, Duyvendak Michiel , Luttikhuis Karen Oude , Ros Johannes JW , Vasbinder Erwin C , Atrafi Maryam , Brasse Bjorn , Mangelaars Iris 
Published: June 2017

Abstract

Objective
To study the association of workarounds with medication administration errors using barcode-assisted medication administration (BCMA), and to determine the frequency and types of workarounds and medication administration errors.

Materials and Methods
A prospective observational study in Dutch hospitals using BCMA to administer medication. Direct observation was used to collect data. Primary outcome measure was the proportion of medication administrations with one or more medication administration errors. Secondary outcome was the frequency and types of workarounds and medication administration errors. Univariate and multivariate multilevel logistic regression analysis were used to assess the association between workarounds and medication administration errors. Descriptive statistics were used for the secondary outcomes.

Results
We included 5793 medication administrations for 1230 inpatients. Workarounds were associated with medication administration errors (adjusted odds ratio 3.06 [95% CI: 2.49-3.78]). Most commonly, procedural workarounds were observed, such as not scanning at all (36%), not scanning patients because they did not wear a wristband (28%), incorrect medication scanning, multiple medication scanning, and ignoring alert signals (11%). Common types of medication administration errors were omissions (78%), administration of non-ordered drugs (8.0%), and wrong doses given (6.0%).

Discussion
Workarounds are associated with medication administration errors in hospitals using BCMA. These data suggest that BCMA needs more post-implementation evaluation if it is to achieve the intended benefits for medication safety.

Conclusion
In hospitals using barcode-assisted medication administration, workarounds occurred in 66% of medication administrations and were associated with large numbers of medication administration errors.
Rate Manuscript (Oxford, Bodleian Library, MS Ashmole 61)
Authors: Matlock Wendy 
Published: June 2017

Oxford, Bodleian Library, MS Ashmole 61 is often referred to as the Rate manuscript after the codex’s scribe, who signs the name nineteen times throughout the volume of 162 paper folia and often adds drawings of fish and roses at the ends of texts. The codex measures about 418 mm by 140 mm. It likely was produced for urban household use, given its strong interest in domestic life, including practical material for household maintenance such as recipes and accounting advice along with poems for lay devotion and popular entertainment. Watermark evidence suggests production dates between 1479 and 1610, but the scribe’s hand precludes a date after the first decade of the 16th century, so scholars typically use c. 1500 to date the manuscript. Dialect places Rate in Leicestershire. Little otherwise is known about Rate, but his careless copying and idiosyncratic editing combined with the codex’s unusual format suggest he was an amateur scribe producing the volume for his own or his household’s use. The manuscript compiles forty-one works, although some numbers include multiple or incomplete texts. Its eclectic contents, primarily in Middle English excluding macaronic works and three Latin epigrams, range from short didactic poems and prayers to long devotional treatises like The Northern Passion. It includes literature from a wide range of times and places. Among the earlier are the late-13th-century Saint Eustace and The King and His Four Daughters, which translates part of Robert Grosseteste’s Anglo-Norman Le Château d’Amour, but a majority date to the 15th century. Some are extant only in the Rate manuscript; for example, The Debate of the Carpenter’s Tools and The Feasts of All Saints and All Souls are unique. Other texts, however, circulated widely in later medieval England (e.g., A Prayer to the Virgin Mary, preserved in forty other manuscripts and itself excerpted from the immensely popular Speculum Christiani). Ashmole 61 is noteworthy for its five popular romances: four are signature Middle English tail-rhyme romances—Sir Isumbras, The Erle of Tolous, Lybeaus Desconus, and Sir Cleges—and the fifth is Sir Orfeo. It also includes two comic poems in tail-rhyme stanzas, Sir Corneus and King Edward and the Hermit. The manuscript as a whole compiles works concerning good manners, correct conduct, and the claims of the afterlife, issues of great interest to 15th-century readers. It is often compared to other 15th-century miscellanies, such as Cambridge University Library MS Ff.2.38; Edinburgh National Library of Scotland MS Advocates 19.3.1; Oxford, Bodleian Library MS Rawlinson C. 83; and the Lincoln Thornton MS.
A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children
Authors: Lee Johanna M. , Akeju Oluwaseun , Terzakis Kristina , Pavone Kara J. , Deng Hao , Houle Timothy T. , Firth Paul G. , Shank Erik S. , Brown Emery N. , Purdon Patrick L. 
Published: June 2017

Abstract

Background
In adults, frontal electroencephalogram patterns observed during propofol-induced unconsciousness consist of slow oscillations (0.1 to 1 Hz) and coherent alpha oscillations (8 to 13 Hz). Given that the nervous system undergoes significant changes during development, anesthesia-induced electroencephalogram oscillations in children may differ from those observed in adults. Therefore, we investigated age-related changes in frontal electroencephalogram power spectra and coherence during propofol-induced unconsciousness.

Methods
We analyzed electroencephalogram data recorded during propofol-induced unconsciousness in patients between 0 and 21 yr of age (n = 97), using multitaper spectral and coherence methods. We characterized power and coherence as a function of age using multiple linear regression analysis and within four age groups: 4 months to 1 yr old (n = 4), greater than 1 to 7 yr old (n = 16), greater than 7 to 14 yr old (n = 30), and greater than 14 to 21 yr old (n = 47).

Results
Total electroencephalogram power (0.1 to 40 Hz) peaked at approximately 8 yr old and subsequently declined with increasing age. For patients greater than 1 yr old, the propofol-induced electroencephalogram structure was qualitatively similar regardless of age, featuring slow and coherent alpha oscillations. For patients under 1 yr of age, frontal alpha oscillations were not coherent.

Conclusions
Neurodevelopmental processes that occur throughout childhood, including thalamocortical development, may underlie age-dependent changes in electroencephalogram power and coherence during anesthesia. These age-dependent anesthesia-induced electroencephalogram oscillations suggest a more principled approach to monitoring brain states in pediatric patients.
Earliest English Definitions of Anaisthesia and Anaesthesia
Authors: Haridas Rajesh P. 
Published: June 2017

Abstract
The earliest identified English definition of the word anaisthesia was discovered in the first edition (1684) of A Physical Dictionary, an English translation of Steven Blankaart’s medical dictionary, Lexicon Medicum Graeco-Latinum. This definition was almost certainly the source of the definition of anaesthesia which appeared in Dictionarium Anglo-Britannicum (1708), a general-purpose English dictionary compiled by the lexicographer John Kersey. The words anaisthesia and anaesthesia have not been identified in English medical or surgical publications that antedate the earliest English dictionaries in which they are known to have been defined.
Induction of Endogenous Neural Stem Cells By Extracorporeal Shock Waves After Spinal Cord Injury
Authors: Shin Dong-Cheul , Ha Kee-Yong , Kim Young-Hoon , Kim Jang-Woon , Cho Yoo-Kyung , Kim Sang-Il 
Published: June 2017

Study Design.
Animal experimental study

Objectives.
The purpose of this study is to investigate the effects of extracorporeal shock waves (ESWs) on endogenous neural stem cells (NSCs) proliferation after spinal cord injury (SCI).

Summary of Background Data.
Exogenous stem cell transplantation for SCI still has many limitations to be addressed such as ideal cell sources, timing of transplantation, and fate of the transplanted cells. Moreover, the efficacy is another issue owing to a peculiar pathologic condition in the chronic phase of SCI.

Methods.
Contusive SCI was made using 24 Sprague-Dawley rats, and ESWs were applied at post-injury 4 weeks in rats. Proliferation and differentiation of endogenous NSCs (DCX, Sox-2) and axonal sprouting (GAP-43 and MAP-2) were observed at 6 weeks after application of ESWs. Differentiation of the activated neural stem cells was also investigated by coexpression of neuronal/glial cell markers (GFAP, Neu N, and CC-1). Immunofluorescence staining and western blotting were performed for quantitative analysis, and these results were compared with those in the control group. For clinical assessment, the BBB locomotor rating scale was performed.

Results.
More proliferation of endogenous neural stem cells was noted in the experimental groups, and these activated cells were mainly founded in the ependymal layer of the central canal and the injured posterior horn. Differentiation into neuronal and glial cells was also noted in a limited number of cells. With respect to axonal regeneration, GAP-43 and MAP-2 expressions in the experimental groups were also significantly higher than those in the control group. During 6 weeks’ clinical observation following ESWs application, functional improvement of the hindlimb was observed without clinical deterioration by trials.

Conclusion.
Collectively, these findings indicate that ESWs on the chronic phase of SCI induce activation of endogenous NSCs and consequent functional improvement.

Level of Evidence: N/A
Effect of Postoperative Dressing on Excisions Performed on the Leg: A Comparison Between Zinc Oxide Compression Dressings Versus Standard Wound Care
Authors: Thompson Carol B. , Wiemken Timothy L. , Brown Timothy S. 
Published: June 2017

BACKGROUND
Wound healing on the legs may be complicated by delayed healing and other postoperative problems. Two potential postoperative wound care regimens for sutured excisions on the legs include a standard pressure dressing and zinc oxide compression dressings. Limited data exist comparing the efficacy of these 2 options.

OBJECTIVE
To compare outcomes of standard postoperative wound care dressing versus postoperative use of a zinc oxide compression dressings for sutured repairs on the legs.

METHODS
In this retrospective cohort study, healing time and complication rate of 44 patients treated with standard dressing and 36 patients treated with zinc oxide compression dressings were compared.

RESULTS
At 19 days, 91.7% of patients receiving zinc oxide dressing were fully healed, whereas only 65.9% of patients receiving standard wound care were healed. Complications were noted in 6 of the patients receiving standard dressing (13.6%); no complications occurred in the zinc oxide dressing group.

CONCLUSION
Zinc oxide compression dressings were a practical option for postoperative wound care, with decreased incidence of delayed wound healing, and fewer complications versus standard postoperative wound dressing.