bluuebunny/crossref_metadata_2025_split huggingface dataset:
Philadelphia chromosome–like acute lymphoblastic leukemia
Authors: Tasian Sarah K. , Loh Mignon L. , Hunger Stephen P. 
Published: October 2017

AbstractPhiladelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as BCR-ABL1–like ALL, is a high-risk subset with a gene expression profile that shares significant overlap with that of Ph-positive (Ph+) ALL and is suggestive of activated kinase signaling. Although Ph+ ALL is defined by BCR-ABL1 fusion, Ph-like ALL cases contain a variety of genomic alterations that activate kinase and cytokine receptor signaling. These alterations can be grouped into major subclasses that include ABL-class fusions involving ABL1, ABL2, CSF1R, and PDGFRB that phenocopy BCR-ABL1 and alterations of CRLF2, JAK2, and EPOR that activate JAK/STAT signaling. Additional genomic alterations in Ph-like ALL activate other kinases, including BLNK, DGKH, FGFR1, IL2RB, LYN, NTRK3, PDGFRA, PTK2B, TYK2, and the RAS signaling pathway. Recent studies have helped to define the genomic landscape of Ph-like ALL and how it varies across the age spectrum, associated clinical features and outcomes, and genetic risk factors. Preclinical studies and anecdotal reports show that targeted inhibitors of relevant signaling pathways are active in specific Ph-like ALL subsets, and precision medicine trials have been initiated for this high-risk ALL subset.
Effective “activated PI3Kδ syndrome”–targeted therapy with the PI3Kδ inhibitor leniolisib
Authors: Rao V. Koneti , Webster Sharon , Dalm Virgil A. S. H. , Šedivá Anna , van Hagen P. Martin , Holland Steven , Rosenzweig Sergio D. , Christ Andreas D. , Sloth Birgitte , Cabanski Maciej , Joshi Aniket D. , de Buck Stefan , Doucet Julie , Guerini Danilo , Kalis Christoph , Pylvaenaeinen Ilona , Soldermann Nicolas , Kashyap Anuj , Uzel Gulbu , Lenardo Michael J. , Patel Dhavalkumar D. , Lucas Carrie L. , Burkhart Christoph 
Published: October 2017

Abstract
Pathogenic gain-of-function variants in the genes encoding phosphoinositide 3-kinase δ (PI3Kδ) lead to accumulation of transitional B cells and senescent T cells, lymphadenopathy, and immune deficiency (activated PI3Kδ syndrome [APDS]). Knowing the genetic etiology of APDS afforded us the opportunity to explore PI3Kδ inhibition as a precision-medicine therapy. Here, we report in vitro and in vivo effects of inhibiting PI3Kδ in APDS. Treatment with leniolisib (CDZ173), a selective PI3Kδ inhibitor, caused dose-dependent suppression of PI3Kδ pathway hyperactivation (measured as phosphorylation of AKT/S6) in cell lines ectopically expressing APDS-causative p110δ variants and in T-cell blasts derived from patients. A clinical trial with 6 APDS patients was conducted as a 12-week, open-label, multisite, within-subject, dose-escalation study of oral leniolisib to assess safety, pharmacokinetics, and effects on lymphoproliferation and immune dysregulation. Oral leniolisib led to a dose-dependent reduction in PI3K/AKT pathway activity assessed ex vivo and improved immune dysregulation. We observed normalization of circulating transitional and naive B cells, reduction in PD-1+CD4+ and senescent CD57+CD4− T cells, and decreases in elevated serum immunoglobulin M and inflammatory markers including interferon γ, tumor necrosis factor, CXCL13, and CXCL10 with leniolisib therapy. After 12 weeks of treatment, all patients showed amelioration of lymphoproliferation with lymph node sizes and spleen volumes reduced by 39% (mean; range, 26%-57%) and 40% (mean; range, 13%-65%), respectively. Thus, leniolisib was well tolerated and improved laboratory and clinical parameters in APDS, supporting the specific inhibition of PI3Kδ as a promising new targeted therapy in APDS and other diseases characterized by overactivation of the PI3Kδ pathway. This trial was registered at www.clinicaltrials.gov as #NCT02435173.
Innovative Contracting for Pharmaceuticals and Medicaid's Best-Price Rule
Authors: Sachs Rachel , Bagley Nicholas , Lakdawalla Darius N. 
Published: October 2017

Abstract
In recent years, drug manufacturers and private payers have expressed interest in novel pricing models that more closely link a drug's price to its value. Indication-based pricing, outcome-based pricing, drug licenses, and drug mortgages have all been discussed as alternatives to paying strictly for volume. Manufacturers and payers have complained, however, that Medicaid's “best-price rule” inhibits their ability to enter into these new pricing arrangements. This article examines the best-price rule and assesses to what extent, if any, it might frustrate the goal of paying for value. We conclude that the best-price rule is not as serious a problem as it is sometimes made out to be but that it is also not simply a convenient excuse for refusing to try something new. The law here is complex, and moving to a pay-for-value model for drugs will require close coordination among manufacturers, payers, and regulators.
Solid-State 1H and 27Al NMR Studies of DMSO-Kaolinite Intercalates
Authors: Fafard Jonathan , Terskikh Victor , Detellier Christian 
Published: October 2017

AbstractNuclear magnetic resonance (NMR) provides a powerful tool to describe local nuclear environments. In this work, unique structural information on kaolinite and on kaolinite dimethylsulfoxide (DMSO) intercalate were provided by solid-state 1H and 27Al magic-angle spinning (MAS) NMR. The interlayer chemistry of kaolinite (K) was examined by intercalating a select group of highly polar organic molecules or salts into kaolinite as a first step. Once the interlayer space is expanded, the intercalated compounds can be replaced in a second step. Intercalating DMSO into kaolinite to form the DMSO-K intercalate is, thus, a particularly useful first step toward the intercalation of a large variety of molecules, including polymers and ionic liquids. Well developed characterization methods are essential to define the structural modifications of kaolinite, and MAS NMR is a useful complement to other techniques. The use of 1H and 27Al MAS NMR for this purpose has been relatively rare. 1H NMR, nevertheless, can give unique information about kaolinite hydroxyls. Because quadrupolar interactions are sensitive to the local octahedral Al(III) geometry, solid-state 27Al NMR can follow subtle structural modifications in the octahedral sheet. In the present work, the 1H MAS NMR chemical shifts of KGa-1b were unambiguously attributed to the internal surface hydroxyls at 2.7 ppm and to the internal hydroxyls at 1.7 ppm. The 1H MAS NMR chemical shifts of the two methyl groups in DMSO-K are not equivalent and can be attributed to the 2.9 and 4.2 ppm peaks. The 27Al MAS NMR spectra of KGa-1b obtained under different magnetic fields revealed that most of the quadrupolar effects were highly reduced at 21.1 T, whereas the spectra at lower field, 4.7 T, were dominated by quadrupolar effects. The two octahedral Al(III) sites are not equivalent and can be distinguished in the low-field spectral simulation. Increased quadrupolar constants were observed and showed the major perturbations of the local Al symmetry that resulted from DMSO intercalation. Both the 1H and 27Al MAS NMR studies at different magnetic fields afforded important information about the local environments of the kaolinite hydroxyl groups and structural Al(III).
Mothers Parenting a Child With Intellectual Disability in Urban India: An Application of the Stress and Resilience Framework
Authors: John Aesha , Zapata Roblyer Martha 
Published: October 2017

Abstract
We examined relevance of the key constructs of the stress and resilience framework in the urban Indian context. Analyses of interviews with urban Indian mothers (N = 47) of a 3–6 year old child with intellectual disability generated themes on maternal appraisals of the child's disability, perceived stressors, and resources. Mothers seemed to utilize a combination of fact-based and religious explanation to make sense of their child's disability. Parental stressors ranged from child-related factors (diagnosis, behavioral problems) to financial and family-level challenges. However, participants also reported a number of personal, family-level, and societal resources that helped them cope with the stressors. Study findings are discussed in the context of implications for practice, policy, and research.
Consensus Statement of the International Summit on Intellectual Disability and Dementia Related to Nomenclature
Authors: Janicki Matthew P. , McCallion Philip , Splaine Michael , Santos Flavvia H. , Keller Seth M. , Watchman Karen 
Published: October 2017

AbstractA working group of the 2016 International Summit on Intellectual Disability and Dementia was charged to examine the terminology used to define and report on dementia in publications related to intellectual disability (ID). A review of related publications showed mixed uses of terms associated with dementia or causative diseases. As with dementia research in the non-ID population, language related to dementia in the ID field often lacks precision and could lead to a misunderstanding of the condition(s) under discussion, an increasingly crucial issue given the increased global attention dementia is receiving in that field. Most articles related to ID and dementia reporting clinical or medical research generally provide a structured definition of dementia or related terms; social care articles tend toward term use without definition. Toward terminology standardization within studies/reports on dementia and ID, the Summit recommended that a consistent approach is taken that ensures (a) growing familiarity with dementia-related diagnostic, condition-specific, and social care terms (as identified in the working group's report); (b) creating a guidance document on accurately defining and presenting information about individuals or groups referenced; and (c) using definitions and data, such as subjects' ages, sex, level of ID, residential situation, basis for dementia diagnosis, presence of Down syndrome (or other risk conditions), years from diagnosis, and if available, scores on objective measures of changing function, in reports on neuropathologies or cognitive decline or impairment.
The pleasures of muscular bonding in Bring It On and Pitch Perfect
Authors: Colling Samantha 
Published: October 2017

Abstract
This article explores girl teen films from the perspective of pleasure and affect. It starts from the premise that ideologies do not explain pleasures but pleasures can explain why we may be drawn towards certain films. Taking a material-semiotic approach that prioritizes embodiments of feeling, the body and affect the article articulates the ways in which films are designed to invite particular kinaesthetic pleasures. Certain moments in girl teen films are designed to generate a kinaesthetic experience of muscular bonding. This article explores how muscular bonding is created in the films Bring It On, directed by Reed (2000) and Pitch Perfect, directed by Moore (2012). The first celebrates the contained, bourgeois feminine body while the other carnivalizes this body with elements of the grotesque, but both show how Hollywood girlhood is made to feel pleasurable through the kinetic portrayal of collectivity. By focusing on how notions of fun (which sit in accord with postfeminist and neo-liberal ideologies) feel pleasurable we can understand why we might potentially be drawn to this version of girlhood.
The undeniable pleasures of Tabu’s return
Authors: Harvey James 
Published: October 2017

Abstract
Miguel Gomes’s Tabu (2012) was met with widespread critical appreciation upon release, with much attention lavished upon its rich, romantic imagery, texture and tone. The film divides itself historically (split between contemporary Lisbon and colonial Mozambique) and stylistically (between 35mm and 16mm film), which brought further acclaim for its nuanced take on history and form. However, this historical context provides the backdrop for a love story, leaving Portugal’s colonial legacy as a haunting subtext for the romance that unfolds. Tabu is notable for its stylistic flair, aesthetic beauty and evocation of sensation, over and above its arguable moral duty to engage with the past. As such, the film’s treatment of colonialism has been viewed as aesthetic opportunism. In response, this article explores Tabu’s treatment of film history as a form of critical nostalgia, showing how it harnesses what Robert Stam and Ella Shohat described as the ‘undeniable pleasures’ of Eurocentric media.
The pleasure of repetition: The Bombay cinema and the South American telenovela
Authors: Seijo-Richart María 
Published: October 2017

Abstract
South American television soap operas (telenovelas) follow the same strand of melodrama as mainstream Hindi cinema, referred to here as Bombay cinema. Characters tend to be archetypes and the emphasis is on generating an emotional reaction. Both types of screen fiction attract legions of loyal fans, with series or films even acquiring cult status. At the same time, the critics and the educated elite of their respective countries brand the forms ‘repetitive’ because telenovelas and Bombay cinema rely on predictable formulae and many productions are remakes or transpositions, especially from foreign sources. I propose that the audiences of telenovelas and Bombay cinema derive pleasure precisely from repetition. Accusations of a lack of originality disregard the influence in their narratives of the oral storytelling tradition, in which what was important was not whether the audience knew the story but how engagingly it was told. Moreover, the predictability of the formula allows audiences to experience intense emotions safely and even to flaunt social rules.
Water-based, surfactant-free cytocompatible nanoparticle-microgel-composite biomaterials – rational design by laser synthesis, processing into fiber pads and impact on cell proliferation
Authors: Million Nina , Coger Vincent , Wilke Philipp , Rehbock Christoph , Vogt Peter M. , Pich Andrij , Barcikowski Stephan 
Published: October 2017

AbstractThis work highlights the laser-based aqueous synthesis and processing of nanocomposites, composed of zinc or iron nanoparticles embedded in a
The way Syrian refugees in Turkey use media: Understanding “connected refugees” through a non-media-centric and local approach
Authors: Smets Kevin 
Published: October 2017

Abstract
This paper reports on an exploratory, qualitative study of media
use among Syrian refugees in Turkey, focusing on two locations: a
refugee camp in Sanliurfa (South-Eastern Turkey) and a community
center in Istanbul. It seeks to provide new angles for conceptualizing
the “connected refugee” by adopting a non-media-centric and
ethnographic approach that emphasizes diversity, local contexts and
everydayness. Firstly, the paper discusses the interplay between
individual and collective ownership of media and ICTs, which is linked
to certain power dynamics and an informal economy of solidarity.
Secondly, the role of popular media (e.g., music, television series,
football) for establishing ontological security in an interstitial and
unstable position is discussed.
Placenta increta complicating a second trimester cervical pregnancy: a case report
Authors: Tamhane Nupur , Parikh Aditi , Joshi Vivek M. 
Published: October 2017

Abstract
Cervical ectopic pregnancy is defined as implantation of the embryo in the endocervical canal below the level of the internal os. It is a rare condition that accounts for 0.15% of all ectopic pregnancies. As it can lead to complications such as uncontrolled hemorrhage, it is associated with high morbidity and mortality. This paper illustrates a rare case of a 2nd trimester cervical pregnancy with failed conservative management due to the limitations of ultrasonography. Successful conservative management requires not only early diagnosis but also usage of other sophisticated techniques such as magnetic resonance imaging (MRI) that can help in detecting adherent placenta.
Influence of Business Incubators Performance on Entrepreneurial Intentions and Its Antecedents during the Pre-incubation Stage
Authors: Giordano Martínez Karla Roxana , Fernández-Laviada Ana , Herrero Crespo Ángel 
Published: October 2017

AbstractThe pre-incubation phase is critical in the forming of entrepreneur’s intention and however it is almost missing in literature. Using the entrepreneurship models based on the beliefs–attitude–intention relationship, a sample of 167 pre-incubated entrepreneurs within the well-known System of Business Incubators of the Monterrey Institute of Technology and Higher Education was surveyed and its statistical analysis developed with Structural Equation Modelling methodology. Our findings confirm that (1) entrepreneur’s perception concerning the incubator’s performance directly and positively affects the desirability, self-efficacy and the facilitating conditions, (2) the perceived desirability and feasibility in entrepreneurship, as well as the first ones, self-efficacy and facilitating conditions, positively influence the entrepreneurial intentions. Furthermore, contrary to the traditional mind-set that supports risk is a barrier, results suggest that (3) the risk perceived by pre-incubated entrepreneurs positively influences entrepreneurial intentions and the desirability that is attributed to that behaviour. Finally, these results also provide insights for organizational leaders and policymakers into managing business incubators and organising their formative programs. The effectiveness of incubators is clear but it is also important to communicate it properly so that incubated individuals can perceive it.
Der ausgeloste Bischof. Zu Situation und Funktion des Losverfahrens bei der Besetzung hoher Kirchenämter im Mittelalter
Authors: Wagner Wolfgang Eric 
Published: October 2017

Zusammenfassung
Der Aufsatz geht der Frage nach, in welchen historischen Situationen, unter welchen Bedingungen, auf das Losverfahren bei der Besetzung hoher kirchlicher Ämter in den christlichen Institutionen des Mittelalters zurückgegriffen wurde. Im Mittelpunkt stehen dabei mögliche Motive der Beteiligten, diesem Entscheidungsmodus gegenüber der Wahl den Vorzug zu geben. Außer dem Beweggrund, für jeden die Zugänglichkeit von Ämtern zu ermöglichen und bestimmte, ungleich verteilte Qualifikationen auszuschließen, lassen sich weitere Motive der Akteure feststellen. So ist zunächst in allen betrachteten Fällen eine Externalisierung der Entscheidung, das heißt, eine Übertragung auf eine äußere Instanz, und zwar Gott, zu konstatieren. In mehreren Fällen ist zudem eine Anwendung des Losverfahrens zur Abwehr äußerer Einflussnahmen und zur Lösung von Konflikten zu beobachten. So griff man insbesondere bei gleichstarker Kräfteverteilung zwischen den Konfliktparteien als Kompromiss auf das Losen zurück. Für reformorientierte christliche Gemeinschaften wie die Katharer und die Böhmischen Brüder diente der Bezug auf das Losen in der urchristlichen Gemeinde in erster Linie dazu, sich deutlich von der Amtskirche abzusetzen; man stellte sich damit bewusst außerhalb des Kirchenrechts. Zugleich war aus dem Exempel der Heiligen Schrift eine starke Legitimation für die eigene Position zu beziehen. Der knappe Überblick über die Organisierung von Losverfahren bei der Besetzung hoher Kirchenämter im Mittelalter macht deutlich, dass eine Entscheidungsfindung durch das Los keineswegs irrational ist.
Humanitäre Hilfe im Zeitalter Napoleons. Bürgerliche Gesellschaft und transnationale Ressourcen am Beispiel Erfurts
Authors: Götz Norbert , Palmowski Frank 
Published: October 2017

Zusammenfassung
Zusammenfassung
Dieser Artikel untersucht am Beispiel Erfurts die Verteilung humanitärer Hilfsgelder des Londoner „Committee for Relieving the Distresses in Germany and Other Parts of the Continent“ (1805–1815). Der Schwerpunkt liegt auf den Jahren 1814 und 1815, denn die Quellen zur ersten Hilfskampagne der Jahre 1805 und 1806 sind spärlich. In beiden Fällen spielten deutsche Immigrantennetzwerke innerhalb der britischen Bibelgesellschaft eine entscheidende Rolle, im hier vorgestellten Falle insbesondere der in Erfurt gebürtige Londoner Pastor Ernst August Schwabe. Der Artikel beleuchtet die organisatorische Abwicklung der Hilfe und zeigt, wie die Londoner und Erfurter Zivilgesellschaft über die Hilfskampagne miteinander verzahnt waren und wie das Erfurter Verteilungskomitee aufgrund seines lokalen Horizonts nicht in die ihm zugedachte überregionale Rolle hineinwuchs. Er macht divergierende Interessen der Geber auf unmittelbare Nothilfe und der Empfänger auf langfristige Nutzung der bereitgestellten Ressourcen deutlich. Ein Großteil der Hilfe kam am Ende einem Fonds für Kriegswaisen zugute, dessen Ausschüttungen in der Praxis vom örtlichen Frauenverein kontrolliert wurden.
Innovation und Ressentiment. Ernst Kantorowicz im historiographischen Diskurs der Weimarer Republik
Authors: Greiert Andreas 
Published: October 2017

Zusammenfassung
Mit seiner Zurückweisung naturwissenschaftlicher Vorgehensweisen und seiner Betonung eines künstlerischen Charakters der Geschichtsschreibung bezieht Ernst Kantorowicz zur Zeit der Weimarer Republik geschichtstheoretische Positionen in unmittelbarer Nachbarschaft zu J. G. Droysen und bereichert die deutsche Geschichtsschreibung der Zwischenkriegszeit um einen fraglos bemerkenswerten und theoretisch anspruchsvollen Beitrag. Gerade mit seiner entschiedenen Zeitbezogenheit, mit dem Versuch, mythische Bilder zur Kompensation eines historisch beschädigten Nationalgefühls zu instrumentalisieren, erscheint Kantorowicz’ Ansatz indes im 21. Jahrhundert als obsolet. Ein Vergleich mit dem zeitgenössischen Geschichtsdenken Walter Benjamins verdeutlicht, dass eben die Motive, in denen Kantorowicz’ „Kaiser Friedrich der Zweite“ das „geheime Deutschland“ des George-Kreises repräsentiert, im gegenwärtigen Wissenschaftsdiskurs nur noch verstörend wirken können.
Preparation of Mo/HZSM-5/Bentonite Catalyst for Methane Aromatization in a Fluidized Bed Reactor
Authors: Lasobras J , Medrano J.A , Soler J , Herguido J , Menéndez M , Jimenez A , Da Silva M , Franco M.J , Barrio I , Lázaro J 
Published: October 2017

Abstract
Methane aromatization is a promising technology for the transformation of natural gas to added-value products. The main objective of this work was to obtain a catalyst with suitable performance and good mechanical stability for methane aromatization reaction in fluidized bed reactors. The selected catalyst was Mo/H-ZSM-5/bentonite mixture. Mo/ZSM-5 was chosen as the active material, since it provides good selectivity to aromatics but the particle size of the zeolite was too small for operation in a fluidized bed and a binder was needed. We prepared two series of catalysts with two different zeolites. We tested several heating velocities (1, 7 and 10 °C min‒1) in the different stages of catalyst synthesis. Methane conversion and selectivity to aromatic products improved when using gentle thermal treatments, increasing 2% and 10%, respectively, for the best catalyst tested.
An extension of the method of brackets. Part 1
Authors: Gonzalez Ivan , Kohl Karen , Jiu Lin , Moll Victor H. 
Published: October 2017

Abstract
The method of brackets is an efficient method for the evaluation of alarge class of definite integrals on the half-line. It is based on a small collection of rules, some of which are heuristic. The extension discussed here is based on the concepts of null and divergent series. These are formal representations of functions, whose coefficients an have meromorphic representations for n ∈ ℂ, but might vanish or blow up when n ∈ ℕ. These ideas are illustrated with the evaluation of a variety of entries from the classical table of integrals by Gradshteyn and Ryzhik.