bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare Quality Indicators for Physiotherapy Management in Hip and Knee Osteoarthritis and Rheumatoid Arthritis: A Delphi Study
Authors: Peter W. F. , Hurkmans E. J. , van der Wees P. J. , Hendriks E. J. M. , van Bodegom‐Vos L. , Vliet Vlieland T. P. M. 
Published: January 2016

AbstractObjectivesThe aim of the present study was to develop healthcare quality indicators (HCQIs) for the physiotherapy (PT) management of patients with hip or knee osteoarthritis (HKOA) or rheumatoid arthritis (RA) in the Netherlands.MethodsTwo multidisciplinary expert panels, including patients, were instituted. A draft HCQI set was derived from recommendations included in two existing Dutch PT guidelines for HKOA and RA. The panels suggested additional topics, after which a Delphi procedure was performed. All propositions were scored for their potential to represent good‐quality PT care (score range 0–9). Based on predefined rules, the Delphi panel HCQIs were discussed and selected. Lastly, every indicator was rephrased, resulting in its output consisting of a numerator and denominator, to facilitate comparisons within and among practices.ResultsAfter two Delphi rounds, two final sets of 17 HCQI – one for HKOA and one for RA – were composed, both containing 16 process indicators (regarding initial assessment, treatment and evaluation) and one outcome indicator.ConclusionsTwo sets of HCQIs for PT management in HKOA and RA were developed for measuring the quality of PT care in daily clinical practice. Each indicator was formulated in a measurable way. Future research should focus on the feasibility of both indicator sets for daily clinical practice.
A protocol to develop clinical guidelines for inclusion‐body myositis
Authors: Jones Katherine L. , Sejersen Thomas , Amato Anthony A. , Hilton‐Jones David , Schmidt Jens , Wallace Amanda C. , Badrising Umesh A. , Rose Michael R. ,   the Ibm Guideline Development Group
Published: January 2016

ABSTRACTIntroductionInclusion‐body myositis (IBM) is a late‐onset idiopathic inflammatory myopathy associated with selective and progressive muscle weakness and atrophy. Current clinical management of IBM is largely supportive due to its uncertain etiology and lack of effective treatment. Establishing a consensus of opinion on questions relating to diagnosis and management of IBM is expected to help reduce inconsistencies in the care and resources allocated to those living with this condition.MethodsA protocol has been developed to produce best practice clinical guidelines for IBM based on a combination of published research and expert consensus.ConclusionsIn this study we describe the proposed protocol for developing methods for producing robust and transparent clinical guidance on aspects of diagnosis, drug treatment, physical and practical management, respiration, nutrition and cardiac management, psychosocial management, and multidisciplinary care. Muscle Nerve 53: 503–507, 2016
Skin biopsy in assessing meralgia paresthetica
Authors: Wongmek Arada , Shin Susan , Zhou Lan 
Published: January 2016

AbstractIntroduction: Meralgia paresthetica is a focal neuropathy caused by compression of the lateral femoral cutaneous nerve (LFCN). The disease can be difficult to assess by neurophysiological or imaging studies. Methods: We studied 5 patients who presented to our neuromuscular clinic from April 2012 to December 2014 with a clinical suspicion of meralgia paresthetica and had skin biopsies with intraepidermal nerve fiber density (IENFD) evaluation. Results: The mean age at onset was 37.2 (range 21–59) years. There were 4 women and 1 man. Two were obese, 2 wore tight jeans, and 1 had mild diabetes mellitus. IENFD was reduced in the symptomatic proximal thigh in all 5 patients and was also reduced in the asymptomatic thigh in 2 patients. It was normal in the distal leg in 4 patients. Conclusion: Meralgia paresthetica is associated with loss of small intraepidermal nerve fibers. Skin biopsy with IENFD evaluation may be a useful diagnostic tool for this disease. Muscle Nerve 53: 641–643, 2016
Next generation sequencing reveals ryanodine receptor 1 mutations in a Chinese central core disease cohort
Authors: Zhao Yan , Hu Jing , Zhao Zhe , Shen Hongrui , Bing Qi , Li Nan 
Published: January 2016

ABSTRACTIntroductionRyanodine receptor 1 (RYR1), myosin heavy chain 7 (MYH7), and selenoprotein N1 (SEPN1) mutations are associated with core myopathies. RYR1 mutations cause most cases of central core disease (CCD). Methods: We screened 8 Chinese patients with clinicopathological diagnosis of CCD. Genetic analysis was carried out by targeted next generation sequencing (NGS) to identify causative genes. Variants were assessed for pathogenicity using bioinformatic approaches, and NGS results were confirmed by Sanger sequencing. Results: One novel (p.L4578V) and heterozygous missense mutations in RYR1 were identified in 7 patients. Two patients carried a novel mutation, 1 had p.M4640R, 3 had p.R4861H, and 1 had p.R4861C. All patients had mild to moderate severity phenotypes. Histopathological findings demonstrated central cores and type I fiber predominance. Conclusions: NGS is an efficient strategy to identify variants in RYR1 in CCD. However, genetic results revealed by NGS must be combined with clinicopathologic features to validate the diagnosis. Muscle Nerve, 2016 Muscle Nerve 54: 432–438, 2016
On the fast Lanczos method for computation of eigenvalues of Hankel matrices using multiprecision arithmetics
Authors: Bangay Shaun , Beliakov Gleb 
Published: January 2016

SummaryThe use of the fast Fourier transform (FFT) accelerates Lanczos tridiagonalisation method for Hankel and Toeplitz matrices by reducing the complexity of matrix–vector multiplication. In multiprecision arithmetics, the FFT has overheads that make it less competitive compared with alternative methods when the accuracy is over 10000 decimal places. We studied two alternative Hankel matrix–vector multiplication methods based on multiprecision number decomposition and recursive Karatsuba‐like multiplication, respectively. The first method was uncompetitive because of huge precision losses, while the second turned out to be five to 14 times faster than FFT in the ranges of matrix sizes up to n = 8192 and working precision of b = 32768 bits we were interested in. We successfully applied our approach to eigenvalues calculations to studies of spectra of matrices that arise in research on Riemann zeta function. The recursive matrix–vector multiplication significantly outperformed both the FFT and the traditional multiplication in these studies. Copyright © 2016 John Wiley & Sons, Ltd.
Development of a Cultural Awareness Scale for Occupational Therapy Students in Latin America: A Qualitative Delphi Study
Authors: Castro Daniela , Dahlin‐Ivanoff Synneve , Mårtensson Lena 
Published: January 2016

AbstractCultural awareness is a key issue in healthcare worldwide. Valid and reliable assessments are needed to assess cultural awareness for occupational therapy students. The purpose of this study was to develop a scale to assess cultural awareness for Latin American occupational therapy students. A Delphi design was implemented considering four rounds with experts from four countries. A 30‐item scale in Spanish was developed to assess three categories of items: personal, therapeutic strategies and persons' cultures. The experts highlighted local features for professional practice as a key aspect of the scale. Local differences in practice were considered with the profession's traditions and prevailing knowledge across the scale. A participatory strategy and an international group of experts enriched the cultural relevance. A subsequent study of statistical reliability is required (the scale is not presented in an extended version here). Further research should consider the application of the scale and strategies to improve cultural awareness across the curricula. Copyright © 2016 John Wiley & Sons, Ltd.
Tuning core hydrophobicity of spherical polymeric nanoconstructs for docetaxel delivery
Authors: Di Mascolo Daniele , Basnett Pooja , Palange Anna Lisa , Francardi Marco , Roy Ipsita , Decuzzi Paolo 
Published: January 2016

AbstractThe reformulation of nanoparticles of chemotherapeutic molecules is often required to enhance their bioavailability, increase blood longevity and eventually improve the outcome of the pharmacological intervention. Docetaxel (DTXL), a potent anti‐cancer drug daily used for the treatment of different neoplastic diseases, is one of such molecules. Here, spherical polymeric nanoconstructs (SPNs) with a characteristic size of 200 nm are designed for the delivery of DTXL. SPNs comprise a hydrophobic polymeric core where the drug is entrapped and are externally stabilized by a lipid monolayer decorated with polyethylene glycol chains. Two different polymers are used for the core formation, namely poly(d,l‐lactide‐co‐glycolic) acid (PLGA), which has been extensively used for similar biomedical applications, and poly(3‐hydroxybutyrate) (P(3HB)), which is a natural polymer produced by a wide variety of bacterial species under nutrient limiting conditions. The two nanoformulations of DTXL are compared in terms of loading, release and cytotoxic drug potential. Consistent with the higher hydrophobicity of P(3HB) over PLGA, the former polymer allows for a higher loading efficiency (almost double that of PLGA) and slower release rates. No significant difference is observed in terms of internalization rate and cytotoxicity potential. This work demonstrates that P(3HB) could be a valid alternative to the more conventional PLGA for the delivery and controlled release of hydrophobic therapeutic molecules. © 2016 Society of Chemical Industry
III‐Vs at scale: a PV manufacturing cost analysis of the thin film vapor–liquid–solid growth mode
Authors: Zheng Maxwell , Horowitz Kelsey , Woodhouse Michael , Battaglia Corsin , Kapadia Rehan , Javey Ali 
Published: January 2016

AbstractThe authors present a manufacturing cost analysis for producing thin‐film indium phosphide modules by combining a novel thin‐film vapor–liquid–solid (TF‐VLS) growth process with a standard monolithic module platform. The example cell structure is ITO/n‐TiO2/p‐InP/Mo. For a benchmark scenario of 12% efficient modules, the module cost is estimated to be $0.66/W(DC) and the module cost is calculated to be around $0.36/W(DC) at a long‐term potential efficiency of 24%. The manufacturing cost for the TF‐VLS growth portion is estimated to be ~$23/m2, a significant reduction compared with traditional metalorganic chemical vapor deposition. The analysis here suggests the TF‐VLS growth mode could enable lower‐cost, high‐efficiency III‐V photovoltaics compared with manufacturing methods used today and open up possibilities for other optoelectronic applications as well. Copyright © 2016 John Wiley & Sons, Ltd.
Uncovering smartphone usage patterns with multi‐view mixed membership models
Authors: Virtanen Seppo , Rost Mattias , Morrison Alistair , Chalmers Matthew , Girolami Mark 
Published: January 2016

We present a novel class of mixed membership models for combining information from multiple data sources inferring inter‐view and intra‐view statistical associations. An important contemporary application of this work is the meaningful synthesis of data sources corresponding to smartphone application usage, app developers' descriptions and customer feedback. We demonstrate the ability of the model to infer meaningful, interpretable and informative app usage patterns based on the app usage data augmented with rich text data describing the apps. We provide quantitative model evaluations showing the model provides significantly better predictive ability than comparative related existing methods. © 2016 The Authors. Stat Published by John Wiley & Sons Ltd
The regulation of transcriptome responses in zebrafish embryo exposure to triadimefon
Authors: Hsu Li‐Sung , Chiou Bin‐Hao , Hsu Tung‐Wei , Wang Chien‐Chia , Chen Ssu Ching 
Published: January 2016

ABSTRACTThe residue of triadimefon (TDF) (a pesticide) has become the pollutant in water due to its intensive use in agriculture and medicine, and its stability in water leaching from soil and vegetation. In this study, RNA‐seq, a high‐throughput method was performed, to analyze the global expression of differential expressed genes (DEGs) in zebrafish embryos treated with TDF (10 μg/mL) from fertilization to 72 h post‐fertilization (hpf) as compared with that in the control group (without TDF treatment). Two cDNA libraries were generated from treated and non‐treated embryos, respectively. With the 79.4% and 78.8% of reads mapped to the reference, it was observed that many differential genes were expressed between the two libraries. The most 20 differentially expressed up‐regulated or down‐regulated genes were involving in the signaling transduction, the activation of many genes related to cytochrome P450 enzymes, and molecular metabolism. Validation of seven genes expression confirmed RNA‐seq results. The transcriptome sequences were further subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and showed diverse biological functions and metabolic pathways. The data from this study contributed to a better understanding of the potential consequences of fish exposed to TDF, and to evaluate the potential threat of TDF to fish population in the aquatic environment. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 217–226, 2017.
Making graphene nanoribbons: a theoretical exploration
Authors: Chen Qian , Ma Liang , Wang Jinlan 
Published: January 2016

Graphene nanoribbons (GNRs), thin and long strips of single carbon layer, exhibit very charming electronic and magnetic properties, and show great promising applications in electronics and optoelectronics devices. Therefore, reliable and efficient techniques of making high‐quality GNRs have attracted enormous interests in recent years. Numerous methods of making GNRs, including both top‐down and bottom‐up schemes, have been developed, and among them, metal‐catalyzed and oxidative cutting of graphene and/or carbon nanotube as two most promising approaches have been widely used to fabricate GNRs with different widths, edges, and defects. However, precise control of mass production of narrow GNRs with well‐defined and smooth edges is still very challenging. To reach this goal, it is essential to well understand the underlying mechanisms of making GNRs in different conditions, such as the force that drives the cutting process, catalyst, and agent‐dependent cutting behavior, orientation‐selective cutting at the atomic level. Recently, theoretical investigations based on quantum chemical calculations have made great progress in this area. WIREs Comput Mol Sci 2016, 6:243–254. doi: 10.1002/wcms.1246This article is categorized under:

Structure and Mechanism > Computational Materials Science
Atomistic molecular dynamics simulations of ATP‐binding cassette transporters
Authors: Liu Hui , Li Dan , Li Youyong , Hou Tingjun 
Published: January 2016

Membrane transporters are transmembrane proteins that facilitate the translocation of a broad range of substrates across biological membranes. These proteins play a pivotal role in drug absorption, distribution, metabolism, and excretion, as well as drug resistance in cancer and pathogenic microorganisms. Moreover, some of them are appealing therapeutic targets. Computational methods, especially atomistic molecular dynamics (MD) simulations, are now increasingly employed to investigate the structural and thermodynamic properties of these proteins. Computer simulations at an atomic resolution help to decipher the underlying mechanisms of these transporters and provide valuable insights into structure‐based drug discovery. Here, recent advances of the applications of MD simulations on the studies of a major class of membrane transporters, the ATP‐binding cassette (ABC) superfamily, are reviewed. The studies surveyed here are mainly focused on the working mechanisms of ABC transporters, including binding of substrates, conformational coupling between nucleotide‐binding domains (NBDs) and transmembrane domains, dynamics of NBDs, and global movement of complete transporters. In addition, structural and functional changes upon mutations are also discussed in some medically relevant cases. WIREs Comput Mol Sci 2016, 6:255–265. doi: 10.1002/wcms.1247This article is categorized under:

Structure and Mechanism > Computational Biochemistry and Biophysics
The mammalian blastocyst
Authors: Frankenberg Stephen R. , de Barros Flavia R.O. , Rossant Janet , Renfree Marilyn B. 
Published: January 2016

The blastocyst is a mammalian invention that carries the embryo from cleavage to gastrulation. For such a simple structure, it exhibits remarkable diversity in its mode of formation, morphology, longevity, and intimacy with the uterine endometrium. This review explores this diversity in the light of the evolution of viviparity, comparing the three main groups of mammals: monotremes, marsupials, and eutherians. The principal drivers in blastocyst evolution were loss of yolk coupled with evolution of the placenta. An important outcome of blastocyst development is differentiation of two extraembryonic lineages (trophoblast and hypoblast) that contribute to the placenta. While in many species trophoblast segregation is often coupled with blastocyst formation, in marsupials and at least some Afrotherians, these events do not coincide. Thus, many questions regarding the conservation of molecular mechanisms controlling these events are of great interest but currently unresolved. WIREs Dev Biol 2016, 5:210–232. doi: 10.1002/wdev.220This article is categorized under:

Early Embryonic Development > Fertilization to Gastrulation
Comparative Development and Evolution > Model Systems
Comparative Development and Evolution > Evolutionary Novelties
Cyclodextrin‐based nanosponges: a versatile platform for cancer nanotherapeutics development
Authors: Swaminathan Shankar , Cavalli Roberta , Trotta Francesco 
Published: January 2016

Nanosponges (NSs) are a new age branched cyclodextrin (CD) polymeric systems exhibiting tremendous potential in pharmaceutical, agro science, and biomedical applications. Over the past decade, different varieties of NS based on the type of CD and the crosslinker have been developed tailored for specific applications. NS technology has been instrumental in achieving solubilization, stabilization, sustained release, enhancement of activity, permeability enhancement, protein delivery, ocular delivery, stimuli sensitive drug release, enhancement of bioavailability, etc. There is a major explosion of research in the area of NS‐aided cancer therapeutics. A wide of anticancer molecules both from a pharmacological and physicochemical perspective have been developed as NS formulations by several groups including ours. Our objective in this review is to capture a systematic and comprehensive snapshot of the state‐of‐the‐art of NS‐aided cancer therapeutics reported so far. This review will provide an ideal platform for both the formulation scientists working on new polymeric/drug development and cancer biologists/scientists to understand the current nanotechnologies in CD‐based NS‐aided cancer therapeutics. The scope of the review is limited to small molecules and CD‐based NS. The review covers in detail the problems associated with anticancer small molecules, and the solution provided by CD‐based NS specifically for camptothecin, curcumin, paclitaxel, tamoxifen, resveratrol, quercetin, oxygen‐NS, temozolomide, doxorubicin, and 5‐Fluorouracil. WIREs Nanomed Nanobiotechnol 2016, 8:579–601. doi: 10.1002/wnan.1384This article is categorized under:

Therapeutic Approaches and Drug Discovery > Emerging Technologies
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
The use of faeces counts to estimate relative densities of wild boar in a Mediterranean area
Authors: Ferretti Francesco , Fattorini Lorenzo , Sforzi Andrea , Pisani Caterina 
Published: January 2016

AbstractThe monitoring of population trends of wild ungulates is important to evaluate their population dynamics and to develop sound conservation/management plans. The wild boar Sus scrofa can impose heavy impacts on ecosytems and human activities, as well as be responsible for disease transmission. Estimating abundance of wild boars is a challenging issue, because of some peculiar biological and ecological traits of this ungulate. Indices of relative abundance could be used to evaluate its population trends. In a Mediterranean area we used faeces counts, through a two‐stage stratified sampling, to estimate relative densities of wild boars, between 2007 and 2014. Faeces density estimates increased not significantly between 2007 (151.5 faeces/100 ha) and 2010 (203.8 faeces/100 ha) and decreased significantly from 2010 to 2014 (95.5 faeces/100 ha). The decrease in faeces density estimates was consistent with the increased harvest effort (number of harvest days), performed from 2010 to 2013 to limit impact on ecosystems and reduce damages to crops. The variation of faeces density estimates was also consistent with that of harvest indices (total harvest to harvest effort), with significantly positive values of Pearson and rank correlation coefficients. Results suggest that faeces density estimates achieved with the adopted sampling strategies can be effectively used as indices of relative abundance.
Genomweite Assoziationsstudien zu Adipositas und was wir daraus lernen
Authors: Kronenberg Florian , Paulweber Bernhard , Lamina Claudia 
Published: January 2016

Zusammenfassung
Die Einführung genomweiter Assoziationsstudien (GWAS) führte zu einem sprunghaften Anstieg der Anzahl von Genen, die mit Adipositas und zusammenhängenden Phänotypen wie Body-Mass-Index, Taillenumfang und Taille-Hüft-Quotient assoziiert sind. Dabei ist die Suche nach Genen, die für Übergewicht prädisponieren erst am Anfang, denn der Großteil des geschätzten vererbbaren Anteils von Übergewicht ist noch ungeklärt. Jedes einzelne der 97 bisher bekannten Gene für Body-Mass-Index und 49 Gene für Taille-Hüft-Quotient erklärt nur einen sehr kleinen Anteil der Varianz dieser Phänotypen. Geschlechtsspezifische Unterschiede kennen wir hauptsächlich nur für den Phänotyp Taille-Hüft-Quotient und ca. zwei Fünftel der dafür bekannten Genvarianten weist vor allem bei Frauen einen Effekt auf und keinen oder einen deutlich geringeren Effekt bei Männern. Die funktionelle Charakterisierung dieser Gene wird lange Zeit in Anspruch nehmen. Ob und wie schnell sich aus den Ergebnissen therapeutische Konsequenzen ergeben, lässt sich schwer abschätzen. Das Verständnis involvierter Regelkreise ist aber unabdingbare Voraussetzung für die Entwicklung neuer Therapien.
A Linear Diffusion Model of Adsorption Kinetics at Fluid/Fluid Interfaces
Authors: Staszak Maciej 
Published: January 2016

AbstractThe paper presents a new model for kinetically controlled adsorption at the fluid/fluid interface. The main purpose of the presented approach is to relate easy to estimate bulk surfactant concentration with Gibbs surface excess. Two adsorption isotherms are involved in the new model development: Frumkin and Szyszkowski isotherms. Additionally the Johannsen time profile of concentration in the adsorption layer is assumed and estimated in the model derivation. The proposed approach assumes the near interface, adsorptive layer which is described based on Fick's transient diffusion law. The solution to the model contains the estimation of effective diffusivities with adsorptive layer thickness as well. The experimental results of toluene/water + sodium dodecyl sulfate are presented and used for model verification.