bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Indonesia a Model for the Arab Spring? Islam, Democracy, and Diplomacy
Authors: Hoesterey James B. 
Published: February 2017

As protestors filled Tahrir Square in Cairo in January 2011, Western diplomats, academics, and political pundits were searching for the best political analogy for the promise—and problems—of the Arab Uprising. Whereas neoconservative skeptics fretted that Egypt and Tunisia might go the way of post-revolutionary Iran, Hillary Clinton and Madeleine Albright praised Indonesia’s democratization as the ideal model for the Arab Spring. During her 2009 visit to Indonesia, Clinton proclaimed: “If you want to know whether Islam, democracy, modernity, and women’s rights can coexist, go to Indonesia.” Certainly Indonesia of May 1998 is not Egypt of January 2011, yet some comparisons are instructive. Still reeling from the Asian financial crisis of 1997, middle class Indonesians were fed up with corruption, cronyism, and a military that operated with impunity. On 21 May 1998 Soeharto resigned after three decades of authoritarian rule. Despite fits of starts and stops, the democratic transition has brought political and economic stability. Whereas academics and pundits have debated the merits of the Indonesia model for democratic transition, in this article I consider how the notion of Indonesia as a model for the Arab Spring has reconfigured transnational Muslim networks and recalibrated claims to authority and authenticity within the globalumma.An increasing body of scholarship devoted to global Muslim networks offers important insights into thelongue duréeof merchant traders and itinerant preachers connecting the Middle East with Southeast Asia. In his critique of Benedict Anderson’s famous explanation of “imagined communities” as the result of print capitalismwithinnational borders, historian Michael Laffan argued that Indonesian nationalism had important roots in global Muslim networks connecting the Dutch East Indies with Cairo’s famous al-Azhar University.
Multilevel Models in the Explanation of the Relationship between Safety Climate and Safe Behavior
Authors: Cheyne Alistair , Tomás José M. , Oliver Amparo 
Published: February 2017

AbstractThis study examines the relationships between components of organizational safety climate, including employee attitudes to organizational safety issues; perceptions of the physical working environment, and evaluations of worker engagement with safety issues; and relates these to self-reported levels of safety behavior. It attempts to explore the relationships between these variables in 1189 workers across 78 work groups in a large transportation organization. Evaluations of safety climate, the working environment and worker engagement, as well as safe behaviors, were collected using a self report questionnaire. The multilevel analysis showed that both levels of evaluation (the work group and the individual), and some cross-level interactions, were significant in explaining safe behaviors. Analyses revealed that a number of variables, at both levels, were associated with worker engagement and safe behaviors. The results suggest that, while individual evaluations of safety issues are important, there is also a role for the fostering of collective safety climates in encouraging safe behaviors and therefore reducing accidents.
Dimensionality of the Inventory of Parent and Peer Attachment: Evaluation with the Spanish Version
Authors: Gallarin Miriam , Alonso-Arbiol Itziar 
Published: February 2017

AbstractThree studies aimed at developing the Spanish version of the Inventory of Parent and Peer Attachment (IPPA; Armsden & Greenberg, 1987) and at analyzing its factor structure are reported. In Study 1, the Spanish translation of items and their content analysis was carried out via cognitive interviews. In Study 2, the three-factor structure proposed by authors was tested in a sample of 417 adolescents (270 girls and 147 boys) using confirmatory analysis, and indexes showed a suboptimal fit. A principal component analysis yielded one-dimensional structures in father, mother and peer versions, explaining 54.3%, 50.8%, and 50.8% of the variance respectively. On the basis of the factor loadings and of the item-total correlations, a shortened version of the inventory was created. Convergent validity was tested with measures of family climate, parenting socialization and self-esteem. In Study 3, the one-dimension structure was confirmed in a new sample of 604 adolescents (335 girls and 269 boys). Based on all factor analyses and convergent validity indices obtained, we conclude that the Spanish IPPA questionnaire reliably and validly assesses adolescent attachment using only a dimension of attachment security.
Spanish Version of the Eating Attitudes Test 40: Dimensionality, Reliability, Convergent and Criterion Validity
Authors: Rivas Teresa , Franco Karina , Bersabé Rosa , Montiel Carmen Berrocal 
Published: February 2017

AbstractThe Eating Attitudes Test-40 (EAT-40; Garner & Garfinkel, 1979) is one of the most widely used measures in the field of eating disorders (ED). The factor structure of the EAT-40, as well as the optimal cut-off score to identify subjects with ED, are subjects of debate. Both controversial issues are addressed in the present study. Participants were 95 clinical females meeting DSM-IV-R criteria for ED and 89 females without ED. The results supported a unidimensional structure of the EAT-40 items scores. The general factor accounted for a high percentage (50.63%) of the variance in EAT-40 total scores. The questionnaire proved to have good internal consistency and test–retest reliability. Clinical participants displayed higher mean scores than normal subjects in the EAT-40. Further, participants meeting DSM-IV-R criteria for ED differed significantly from “symptomatic” and “asymptomatic” participants. Correlations with the BULIT-R and the EDI-II scores supported the convergent validity of the questionnaire. The EAT-40 also demonstrated good specificity (94.38%) and sensitivity (93.68%) to detect ED when a cut-off score of 27 was used to discriminate between subjects with and without ED. The implications of these findings for the conceptualization and the assessment of ED are discussed.
TAK1 regulates resident macrophages by protecting lysosomal integrity
Authors: Sakamachi Yosuke , Morioka Sho , Mihaly September R , Takaesu Giichi , Foley Julie F , Fessler Michael B , Ninomiya-Tsuji Jun 
Published: February 2017

AbstractHematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1HKO) caused accumulation of cellular debris in the thymus in perinatal mice. Although no overt alteration in thymocytes and blood myeloid populations was observed in Tak1HKO mice, we found that thymic and lung macrophages were diminished. In the in vitro setting, Tak1 deficiency caused profound disruption of lysosomes and killed bone marrow-derived macrophages (BMDMs) without any exogenous stressors. Inhibition of the lysosomal protease, cathepsin B, partially blocked Tak1-deficient BMDM death, suggesting that leakage of the lysosomal contents is in part the cause of cell death. To identify the trigger of this cell death, we examined involvement of TNF and Toll-like receptor pathways. Among them, we found that deletion of Tnfr1 partially rescued cell death. Finally, we show that Tnfr1 deletion partially restored thymic and lung macrophages in vivo. These results suggest that autocrine and potentially paracrine TNF kills Tak1-deficient macrophages during development. Our results reveal that TAK1 signaling maintains proper macrophage populations through protecting lysosomal integrity.
Starvation at birth impairs germ cell cyst breakdown and increases autophagy and apoptosis in mouse oocytes
Authors: Wang Yong-Yong , Sun Yuan-Chao , Sun Xiao-Feng , Cheng Shun-Feng , Li Bo , Zhang Xi-Feng , De Felici Massimo , Shen Wei 
Published: February 2017

AbstractThe female reproductive lifespan is largely determined by the size of primordial follicle pool, which is established following germ cell cyst breakdown around birth. Almost two-third of oocytes are lost during germ cell cysts breakdown, following autophagic and apoptosis mechanisms. To investigate a possible relationship between germ cell cyst breakdown and nutrition supply, we established a starvation model in mouse pups at birth and evaluated the dynamics of cyst breakdown during nutrient deprivation. Our results showed that after 36 h of starvation between 1.5 and 3 d.p.p., indicators of metabolism both at systemic and ovarian level were significantly altered and the germ cell cyst breakdown markedly decreased. We also found that markers of oxidative stress, autophagy and apoptosis were increased and higher number of oocytes in cyst showing autophagic markers and of TUNEL-positive oocytes and somatic cells were present in the ovaries of starved pups. Moreover, the proliferation of pre-granulosa cells and the expression of the oocyte-specific transcription factor Nobox were decreased in such ovaries. Finally, we observed that the ovaries of the starved pups could recover a normal number of follicles after about 3 weeks from re-feeding. In conclusion, these data indicate that nutrient deficiency at birth can generate a number of adaptive metabolic and oxidative responses in the ovaries causing increased apoptosis both in the somatic cells and oocyte and autophagy mainly in these latter and leading to a delay of germ cell cyst breakdown and follicle assembly.
Epstein–Barr virus particles induce centrosome amplification and chromosomal instability
Authors: Shumilov Anatoliy , Tsai Ming-Han , Schlosser Yvonne T. , Kratz Anne-Sophie , Bernhardt Katharina , Fink Susanne , Mizani Tuba , Lin Xiaochen , Jauch Anna , Mautner Josef , Kopp-Schneider Annette , Feederle Regina , Hoffmann Ingrid , Delecluse Henri-Jacques 
Published: February 2017

AbstractInfections with Epstein–Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells. Viral protein BNRF1 induces centrosome amplification, and BNRF1-deficient viruses largely lose this property. These findings identify a new mechanism by which EBV particles can induce chromosomal instability without establishing a chronic infection, thereby conferring a risk for development of tumours that do not necessarily carry the viral genome.
Boninite-like intraplate magmas from Manihiki Plateau require ultra-depleted and enriched source components
Authors: Golowin Roman , Portnyagin Maxim , Hoernle Kaj , Hauff Folkmar , Gurenko Andrey , Garbe-Schönberg Dieter , Werner Reinhard , Turner Simon 
Published: February 2017

AbstractThe Ontong Java and Manihiki oceanic plateaus are believed to have formed through high-degree melting of a mantle plume head. Boninite-like, low-Ti basement rocks at Manihiki, however, imply a more complex magma genesis compared with Ontong Java basement lavas that can be generated by ∼30% melting of a primitive mantle source. Here we show that the trace element and isotope compositions of low-Ti Manihiki rocks can best be explained by re-melting of an ultra-depleted source (possibly a common mantle component in the Ontong Java and Manihiki plume sources) re-enriched by ≤1% of an ocean-island-basalt-like melt component. Unlike boninites formed via hydrous flux melting of refractory mantle at subduction zones, these boninite-like intraplate rocks formed through adiabatic decompression melting of refractory plume material that has been metasomatized by ocean-island-basalt-like melts. Our results suggest that caution is required before assuming all Archaean boninites were formed in association with subduction processes.
Surface single-molecule dynamics controlled by entropy at low temperatures
Authors: Gehrig J. C. , Penedo M. , Parschau M. , Schwenk J. , Marioni M. A. , Hudson E. W. , Hug H. J. 
Published: February 2017

AbstractConfiguration transitions of individual molecules and atoms on surfaces are traditionally described using an Arrhenius equation with energy barrier and pre-exponential factor (attempt rate) parameters. Characteristic parameters can vary even for identical systems, and pre-exponential factors sometimes differ by orders of magnitude. Using low-temperature scanning tunnelling microscopy (STM) to measure an individual dibutyl sulfide molecule on Au(111), we show that the differences arise when the relative position of tip apex and molecule changes by a fraction of the molecule size. Altering the tip position on that scale modifies the transition’s barrier and attempt rate in a highly correlated fashion, which results in a single-molecular enthalpy-entropy compensation. Conversely, appropriately positioning the STM tip allows selecting the operating point on the compensation line and modifying the transition rates. The results highlight the need to consider entropy in transition rates of single molecules, even at low temperatures.
Effect of novel inhaler technique reminder labels on the retention of inhaler technique skills in asthma: a single-blind randomized controlled trial
Authors: Basheti Iman A. , Obeidat Nathir M. , Reddel Helen K. 
Published: February 2017

AbstractInhaler technique can be corrected with training, but skills drop off quickly without repeated training. The aim of our study was to explore the effect of novel inhaler technique labels on the retention of correct inhaler technique. In this single-blind randomized parallel-group active-controlled study, clinical pharmacists enrolled asthma patients using controller medication by Accuhaler [Diskus] or Turbuhaler. Inhaler technique was assessed using published checklists (score 0–9). Symptom control was assessed by asthma control test. Patients were randomized into active (ACCa; THa) and control (ACCc; THc) groups. All patients received a “Show-and-Tell” inhaler technique counseling service. Active patients also received inhaler labels highlighting their initial errors. Baseline data were available for 95 patients, 68% females, mean age 44.9 (SD 15.2) years. Mean inhaler scores were ACCa:5.3 ± 1.0; THa:4.7 ± 0.9, ACCc:5.5 ± 1.1; THc:4.2 ± 1.0. Asthma was poorly controlled (mean ACT scores ACCa:13.9 ± 4.3; THa:12.1 ± 3.9; ACCc:12.7 ± 3.3; THc:14.3 ± 3.7). After training, all patients had correct technique (score 9/9). After 3 months, there was significantly less decline in inhaler technique scores for active than control groups (mean difference: Accuhaler −1.04 (95% confidence interval −1.92, −0.16, P = 0.022); Turbuhaler −1.61 (−2.63, −0.59, P = 0.003). Symptom control improved significantly, with no significant difference between active and control patients, but active patients used less reliever medication (active 2.19 (SD 1.78) vs. control 3.42 (1.83) puffs/day, P = 0.002). After inhaler training, novel inhaler technique labels improve retention of correct inhaler technique skills with dry powder inhalers. Inhaler technique labels represent a simple, scalable intervention that has the potential to extend the benefit of inhaler training on asthma outcomes.
A small subset of protected areas are a highly significant source of carbon emissions
Authors: Collins Murray B. , Mitchard Edward T. A. 
Published: February 2017

AbstractProtected areas (PAs) aim to protect multiple ecosystem services. However, not all are well protected. For the first time, using published carbon and forest loss maps, we estimate carbon emissions in large forest PAs in tropical countries (N = 2018). We found 36 ± 16 Pg C stored in PA trees, representing 14.5% of all tropical forest biomass carbon. However the PAs lost forest at a mean rate of 0.18% yr−1 from 2000–2012. Lower protection status areas experienced higher forest losses (e.g. 0.39% yr−1 in IUCN cat III), yet even highest status areas lost 0.13% yr−1 (IUCN Cat I). Emissions were not evenly distributed: 80% of emissions derived from 8.3% of PAs (112 ± 49.5 Tg CO2 yr−1; n = 171). Unsurprisingly the largest emissions derived from PAs that started with the greatest total forest area; accounting for starting forest area and relating that to carbon lost using a linear model (r2 = 0.41), we found 1.1% outlying PAs (residuals >2σ; N = 23), representing 1.3% of the total PA forest area, yet causing 27.3% of all PA emissions. These results suggest PAs have been a successful means of protecting biomass carbon, yet a subset causing a disproportionately high share of emissions should be an urgent priority for management interventions.
BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas
Authors: Ibáñez-Costa Alejandro , López-Sánchez Laura M. , Gahete Manuel D. , Rivero-Cortés Esther , Vázquez-Borrego Mari C. , Gálvez María A. , de la Riva Andrés , Venegas-Moreno Eva , Jiménez-Reina Luis , Moreno-Carazo Alberto , Tinahones Francisco J. , Maraver-Selfa Silvia , Japón Miguel A. , García-Arnés Juan A. , Soto-Moreno Alfonso , Webb Susan M. , Kineman Rhonda D. , Culler Michael D. , Castaño Justo P. , Luque Raúl M. 
Published: February 2017

AbstractChimeric somatostatin/dopamine compounds such as BIM-23A760, an sst2/sst5/D2 receptors-agonist, have emerged as promising new approaches to treat pituitary adenomas. However, information on direct in vitro effects of BIM-23A760 in normal and tumoral pituitaries remains incomplete. The objective of this study was to analyze BIM-23A760 effects on functional parameters (Ca2+ signaling, hormone expression/secretion, cell viability and apoptosis) in pituitary adenomas (n = 74), and to compare with the responses of normal primate and human pituitaries (n = 3–5). Primate and human normal pituitaries exhibited similar sst2/sst5/D2 expression patterns, wherein BIM-23A760 inhibited the expression/secretion of several pituitary hormones (specially GH/PRL), which was accompanied by increased sst2/sst5/D2 expression in primates and decreased Ca2+ concentration in human cells. In tumoral pituitaries, BIM-23A760 also inhibited Ca2+ concentration, hormone secretion/expression and proliferation. However, BIM-23A760 elicited stimulatory effects in a subset of GHomas, ACTHomas and NFPAs in terms of Ca2+ signaling and/or hormone secretion, which was associated with the relative somatostatin/dopamine-receptors levels, especially sst5 and sst5TMD4. The chimeric sst2/sst5/D2 compound BIM-23A760 affects multiple, clinically relevant parameters on pituitary adenomas and may represent a valuable therapeutic tool. The relative ssts/D2 expression profile, particularly sst5 and/or sst5TMD4 levels, might represent useful molecular markers to predict the ultimate response of pituitary adenomas to BIM-23A760.
NF-κB regulates neuronal ankyrin-G via a negative feedback loop
Authors: König Hans-Georg , Schwamborn Robert , Andresen Silke , Kinsella Sinéad , Watters Orla , Fenner Beau , Prehn Jochen H. M. 
Published: February 2017

AbstractThe axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximity-ligation experiments in cortical neurons. Overexpression of the 270 kDa variant of ankyrin-G suppressed, while gene-silencing of ankyrin-G expression increased nuclear factor-κB (NF-κB) activity in primary neurons, suggesting that ankyrin-G sequesters the transcription factor in the AIS. We also found that p65 bound to the ank3 (ankyrin-G) promoter sequence in chromatin immunoprecipitation analyses thereby increasing ank3 expression and ankyrin-G levels at the AIS. Gene-silencing of p65 or ankyrin-G overexpression suppressed ank3 reporter activity. Collectively these data demonstrate that p65/NF-κB controls ankyrin-G levels via a negative feedback loop, thereby linking NF-κB signaling with neuronal polarity and axonal plasticity.
No effect of mitochondrial genotype on reproductive plasticity following exposure to a non-infectious pathogen challenge in female or male Drosophila
Authors: Nystrand M. , Cassidy E. J. , Dowling D. K. 
Published: February 2017

AbstractMitochondrial genetic variation shapes the expression of life-history traits associated with reproduction, development and survival, and has also been associated with the prevalence and progression of infectious bacteria and viruses in humans. The breadth of these effects on multifaceted components of health, and their link to disease susceptibility, led us to test whether variation across mitochondrial haplotypes affected reproductive success following an immune challenge in the form of a non-infectious pathogen. We test this, by challenging male and female fruit flies (Drosophila melanogaster), harbouring each of three distinct mitochondrial haplotypes in an otherwise standardized genetic background, to either a mix of heat-killed bacteria, or a procedural control, prior to measuring their subsequent reproductive performance. The effect of the pathogen challenge on reproductive success did not differ across mitochondrial haplotypes; thus there was no evidence that patterns of reproductive plasticity were modified by the mitochondrial genotype following a non-infectious pathogen exposure. We discuss the implications of our data, and suggest future research avenues based on these results.
The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes
Authors: Brennan Melanie S. , Matos Maria F. , Richter Karl E. , Li Bing , Scannevin Robert H. 
Published: February 2017

AbstractDimethyl fumarate (DMF) is indicated for the treatment of relapsing multiple sclerosis and may exert therapeutic effects via activation of the nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway. Following oral DMF administration, central nervous system (CNS) tissue is predominantly exposed to monomethyl fumarate (MMF), the bioactive metabolite of DMF, which can stabilize NRF2 and induce antioxidant gene expression; however, the detailed NRF2-dependent mechanisms modulated by MMF that lead to cytoprotection are unknown. Our data identify a mechanism for MMF-mediated cytoprotection in human astrocytes that functions in an OSGIN1-dependent manner, specifically via upregulation of the OSGIN1-61 kDa isoform. NRF2-dependent OSGIN1 expression induced P53 nuclear translocation following MMF administration, leading to cell-cycle inhibition and cell protection against oxidative challenge. This study provides mechanistic insight into MMF-mediated cytoprotection via NRF2, OSGIN1, and P53 in human CNS-derived cells and contributes to our understanding of how DMF may act clinically to ameliorate pathological processes in neurodegenerative disease.