bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unpacking the discourse surrounding the impact agenda in the Hong Kong Research Assessment Exercise 2020
Authors: Li Danling , Lo William Yat Wai , Yang Rui 
Published: October 2024

Abstract
Research with economic utility and social value has been increasingly valued. Such an emphasis can be evidenced by the newly included assessment element of ‘societal impact’ in performance-based research funding (PBRF) schemes in different higher education systems around the world. This paper investigates how the non-academic impact is constructed and perceived in the Hong Kong Research Assessment Exercise (RAE) 2020, taking into account the local socio-cultural characteristics in the context of Hong Kong. Data sources include 13 impact case studies in the education panel submitted for the Hong Kong RAE 2020 and semi-structured interview with 17 education academics in Hong Kong. Findings revealed that the non-academic impact was constructed through a narrative pattern: (1) problem identification: tensions and synergies between local and international discourse; (2) problem resolution: prioritization of the evidence-based applied education research (with funding); (3) resolution dissemination: strategic employment of promotional genre. The paper discusses how decolonization, academic entrepreneurialism and collectivist culture have characterized the framing and understanding of the non-academic impact in the Hong Kong academia, contributing to the discourse on neoliberalism in higher education by providing a nuanced, local perspective on the impact agenda. Policy implications for a more localized and flexible impact agenda are also provided.
Trajectories of disease evolution upon treatment initiation in systemic lupus erythematosus: results from four clinical trials of belimumab
Authors: Parodis Ioannis , Lindblom Julius , Tsoi Alexander , Palazzo Leonardo , Blomkvist Sporre Karin , Enman Yvonne , Nikolopoulos Dionysis , Beretta Lorenzo 
Published: October 2024

Abstract

Objective
Upon commencement of therapy for active disease, patients with systemic lupus erythematosus (SLE) show varying evolution regarding disease activity measures and patient-reported outcomes (PROs). Our objective was to identify disease evolution trajectories to gain a deeper understanding of SLE progression, ultimately improving future trial design.

Methods
Patients with ≥2 visits and available data on Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), British Isles Lupus Assessment Group (BILAG), Physician Global Assessment (PGA), Functional Assessment of Chronic Illness Therapy—Fatigue (FACIT-F), and glucocorticoid use were included in a post hoc analysis of four randomized controlled trials of belimumab (BLISS-52, BLISS-76, BLISS-SC, EMBRACE). Growth mixture modelling identified latent classes.

Results
Among 2868 patients analysed, baseline median disease duration was 4.5 (interquartile range: 1.5–9.7) years and mean (±standard deviation) Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) 0.7 (±2.0), SLEDAI-2K 10.2 (±3.6), BILAG 17.0 (±7.8), PGA 1.5 (±0.5), FACIT-F 30.6 (±11.9) and prednisone dose 11.0 (±8.9) mg/day. In the initial model, glucocorticoid use and dose yielded high standard errors, indicating a weak link with the latent process. A refined model considered only clinical measures and FACIT-F, corrected for intervention and SDI; no other covariates improved the fit. Four classes best described disease evolution: highly active, responders; highly active, non-responders; moderately active, responders; moderately active, non-responders. Lupus Low Disease Activity State and Definitions of Remission in SLE remission attainment associated with latent classes.

Conclusion
By linking disease activity measures with PROs, we identified four distinct trajectories describing SLE evolution following the initiation of therapy. This classification could be valuable for personalizing treatment and guiding biological studies aimed at distinguishing patients with varying anticipated treatment responses, as no single clinical variable alone can predict disease progression.
30-Month Impact of Medications for Opioid Use Disorder on Acute Care Utilization in Rural Communities
Authors: Maeng Daniel , Russell Holly A. , Conner Kenneth R. , Malcho Jade , Cross Wendi , Lee Hochang B. 
Published: October 2024

Purpose
To assess both the short- and longer-term impact of offering medications for opioid use disorder (MOUD, ie, methadone, buprenorphine, or naltrexone) on rates of all-cause emergency department (ED) visits and acute inpatient admissions (IP) over a 30-month period among Medicaid enrollees with opioid use disorder (OUD) residing in rural communities.

Methods
A quasi-experimental retrospective analysis of longitudinal Medicaid claims data among continuously enrolled adult patients with OUD residing in 71 predominantly rural counties in the United States between 2018 and 2020. A cohort of patients receiving MOUD treatment was compared against a contemporaneous propensity score–matched comparison group consisting of those who received no MOUD during the period.

Findings
The sample included 5370 patients with OUD in each group. At the index period (ie, the month in which any MOUD was used for the first time), buprenorphine was the most commonly used MOUD (82% of the MOUD treatment group). By the eighth month since the index period, MOUD use dropped below 60% among the MOUD treatment group. Over the 30-month post-MOUD period, MOUD treatment was associated with 24% (112 vs 148 per 1000 per month) and 52% (21 vs 44) lower rates of ED visit and IP admission rates, respectively (P < 0.001), relative to the comparison group. Moreover, the reductions persisted well after the 18th month period.

Conclusions
Receipt of MOUD was associated with both immediate- and long-term lower rates in acute care utilization rates among adult Medicaid beneficiaries with OUD residing in rural communities despite significant treatment discontinuation.
Persistent Fatigue, Weakness, and Aberrant Muscle Mitochondria in Survivors of Critical COVID-19
Authors: Mayer Kirby P. , Ismaeel Ahmed , Kalema Anna G. , Montgomery-Yates Ashley A. , Soper Melissa K. , Kern Philip A. , Starck Jonathan D. , Slone Stacey A. , Morris Peter E. , Dupont-Versteegden Esther E. , Kosmac Kate 
Published: October 2024

OBJECTIVES:
Persistent skeletal muscle dysfunction in survivors of critical illness due to acute respiratory failure is common, but biological data elucidating underlying mechanisms are limited. The objective of this study was to elucidate the prevalence of skeletal muscle weakness and fatigue in survivors of critical illness due to COVID-19 and determine if cellular changes associate with persistent skeletal muscle dysfunction.

DESIGN:
A prospective observational study in two phases: 1) survivors of critical COVID-19 participating in physical outcome measures while attending an ICU Recovery Clinic at short-term follow-up and 2) a nested cohort of patients performed comprehensive muscle and physical function assessments with a muscle biopsy; data were compared with non-COVID controls.

SETTING:
ICU Recovery Clinic and clinical laboratory.

PATIENTS/SUBJECTS:
Survivors of critical COVID-19 and non-COVID controls.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
One hundred twenty patients with a median of 56 years old (interquartile range [IQR], 42–65 yr old), 43% female, and 33% individuals of underrepresented race attended follow-up 44 ± 17 days after discharge. Patients had a median Acute Physiology and Chronic Health Evaluation-II score of 24.0 (IQR, 16–29) and 98 patients (82%) required mechanical ventilation with a median duration of 14 days (IQR, 9–21 d). At short-term follow-up significant physical dysfunction was observed with 93% of patients reporting generalized fatigue and performing mean 218 ± 151 meters on 6-minute walk test (45% ± 30% of predicted). Eleven patients from this group agreed to participate in long-term assessment and muscle biopsy occurring a mean 267 ± 98 days after discharge. Muscle tissue from COVID exhibited a greater abundance of M2-like macrophages and satellite cells and lower activity of mitochondrial complex II and complex IV compared with controls.

CONCLUSIONS:
Our findings suggest that aberrant repair and altered mitochondrial activity in skeletal muscle associates with long-term impairments in patients surviving an ICU admission for COVID-19.
Examining Mentor Perception of Competence in an Academic Peer Mentoring Program
Authors: Zwilling Elizabeth , Jeanmougin Caitlin , Cole Britt 
Published: October 2024

Introduction:
Peer mentoring programs can be a valuable support mechanism for new faculty transitioning from clinical practice to academia. Mentors play a crucial role in this process. This study described mentors' perceived competence in 21 areas of the mentor role and their experiences as mentors following the first year of a structured peer mentoring program.

Methods:
This study employed a mixed-methods approach, using the Mentoring Competency Assessment-21 alongside open-ended questions. These instruments were electronically administered to a convenience sample consisting of eight mentors with varying experience ranging from 2 to 16 years in the nursing program at a mid-sized university, following an intentional first-year peer mentoring program.

Results:
The highest-performing items were “Establishing a relationship based on trust” (M 6.50, SD 0.53), “Considering how personal and professional differences may impact expectations” (M 6.25, 0.83), and “Acknowledging your mentee's professional contributions” (M 6.13, SD 0.99). The lowest scores were focused on estimating scientific knowledge and scholarly productivity. Responses to the Mentoring Competency Assessment-21 indicated that mentors felt at least moderately competent in the various aspects of the faculty mentor role. Mentors valued the professional development and supporting materials provided by the development team. An identified area for improvement was the support provided to assist the mentees' scholarly development.

Discussion:
This study underscores the importance of supportive materials, such as handbooks and regular communication, in fostering mentor competence and facilitating successful nursing faculty peer mentoring programs. Future research implications include assessment of mentor competence by mentees and long-term follow-up of program outcomes.
Achieving a Strong and Straight Septal Extension Graft: A Novel Four-step Surgical Approach in Rhinoplasty
Authors: Di Giuli Riccardo , Mafi Pouya , Belloni Laura M. , Vaccari Stefano , Klinger Francesco , Roxo Carlos W. 
Published: October 2024

Background:
Septal extension grafts allow the precise elongation of the nasal septum to attain facial harmony and optimize aesthetic outcomes. In this context, septal surgery requires meticulous design to address both functional and aesthetic goals. Traditional septoplasty techniques often overlook aesthetic considerations and postoperative nasal structural stability, resulting in unresolved or recurrent deviations, nose tip drooping, and obstruction recurrences. Despite advancements in surgical techniques, achieving simultaneous septal alignment and long-term stability remains a significant challenge.

Methods:
This study introduces a systematic 4-step technique. The procedure encompasses caudal septum liberation, placement of the septum extension cartilage graft, positioning of an ethmoidal bone graft, and redefinition through an intermediate cartilage.

Results:
A retrospective analysis of outcomes involving 753 patients was conducted with a minimum follow-up of 6 months. During follow-up visits, 1.73% of cases exhibited residual columellar asymmetry, and 0.66% showed tip asymmetries. The infection rate was 0.40%, with no cases of tip drop identified. The overall satisfaction rating on the Rhinoplasty Outcomes Evaluation questionnaire at 12 months postoperative was 9.3.

Conclusions:
The technique provides a systematic approach to integrate functional and aesthetic objectives, emphasizing septal stability and alignment while concurrently addressing tip projection and stability. The study provides comprehensive insights into the principles, methodology, and advantages of this rhinoplasty technique. The outcomes underscore the efficacy of the technique, presenting a reliable and long-term stable solution.
Retinal vascular abnormality of non-perfusion and neovascularization in a toddler with neurofibromatosis type 1
Authors: Zeng Qiaozhu , Zhong Yusheng , Qian Tong , Cheng Yong 
Published: October 2024

Purpose
This report describes the case of a 13-month-old boy diagnosed with neurofibromatosis type 1, who presented with retinal vascular abnormalities including extensive non-perfusion and neovascularization. We also discuss the observed changes following photocoagulation treatment.

Methods
A 13-month-old boy presented to the Department of Ophthalmology at Peking University People’s Hospital with a reduction in the width of the left palpebral fissure for the past 6 months.

Results
The boy exhibited more than six café-au-lait spots larger than 5 mm in diameter on his trunk and legs. Fundus examination of the left eye revealed significant neovascularization in the temporal periphery of the retina, with late leakage and non-perfusion also noted temporally in fluorescein angiography (FA). Magnetic resonance imaging of the brain and orbits showed an enlarged left sphenoid body, a widened left cavernous sinus, and a large plexiform neurofibroma. Laser treatment was performed on the left eye. Five months later, the neovascularization was controlled.

Conclusion
Careful fundus examinations and systemic reviews, especially FA, are essential. Timely laser treatment is crucial for controlling disease progression and preventing retinal detachment.
A Transdiagnostic Dimensional Approach to Behavioral Dysregulation: Examining Reward and Punishment Sensitivity Across Psychopathology
Authors: Oka Taiki , Sasaki Akihiro , Kobayashi Nao 
Published: October 2024

AbstractAimTheoretically, deficits in reward/punishment sensitivity are considered an essential component associated with behavioral dysregulation, which is characteristic of compulsive-impulsive disorders. However, recent studies have indicated that several disorders are linked to problems with reward/punishment sensitivity, and their results have been inconsistent. This lack of clinical specificity and robustness might reflect more general problems with traditionally diagnostic categories of psychiatry. To address these concerns, we investigated whether a transdiagnostic dimensional approach could more effectively examine clinical associations related to reward/punishment sensitivity for behavioral dysregulation.MethodsUsing multiple psychiatric symptom scores and reward/punishment sensitivity in online general-population samples (N = 19505), we applied factor analyses to extract transdiagnostic symptom dimensions. Then, we conducted a mixed-effect generalized linear model to examine the relationships between psychopathology and reward/punishment sensitivity.ResultsWe extracted three transdiagnostic dimensions, which were validated between two separate datasets: ‘Compulsive hypersensitivity (CH), ‘Social withdrawal (SW),’ and ‘Addictive behavior (AB).’ While SW was associated with reward sensitivity negatively and punishment sensitivity positively, AB showed opposite associations. On the other hand, CH was positively associated with both sensitivities.ConclusionOur results highlight the importance of reward/punishment sensitivity for our understanding of behavioral dysregulation, especially in the compulsive-impulsive dimension. Moreover, these findings underscore how transdiagnostic perspectives contribute to a more powerful examination of reward/punishment deficits than studies focusing on a categorical disorder.
Fine Social Discrimination of Siblings in Mice: Implications for Early Detection of Alzheimer’s Disease
Authors: Fauré Lola MP , Gauzin Sébastien , Lejards Camille , Rampon Claire , Verret Laure 
Published: October 2024

ABSTRACTThe ability to distinguish between individuals is crucial for social species and supports behaviors such as reproduction, hierarchy formation, and cooperation. In rodents, social discrimination relies on memory and the recognition of individual-specific cues, known as "individual signatures". While olfactory signals are central, other sensory cues —such as auditory, visual, and tactile inputs — also play a role. However, little research has explored the fine discrimination of individuals with overlapping cues, such as siblings or cohabitating mice. This study investigates whether mice can discriminate between two closely related individuals: siblings from the same litter and cage. We tested the hypothesis that it would be more challenging for mice to distinguish between siblings than between unrelated mice due to shared cues. Moreover, social cognitive impairments are common in neurodegenerative diseases like Alzheimer’s disease (AD), where difficulties in recognizing faces and voices progressively disrupt social interactions in patients. Using a mouse model of AD (Tg2576), known for the progressive onset of cognitive deficits, we assessed whether the ability to discriminate between siblings is preserved in “pre-symptomatic” animals. Thus, we first demonstrated that male and female C57BL6/J mice can discriminate siblings, regardless of sex. Next, we revealed that “pre-symptomatic” 3-month-old Tg2576 mice exhibit impairments in fine social memory, while their general social memory remains unaffected. Thus, we demonstrate that the inability to perform fine social discrimination is an early cognitive impairment that arises before other well-documented memory abnormalities in this AD mouse model.SIGNIFICANCE STATEMENTDiscriminating between individuals is vital for social species, supporting reproduction, hierarchy formation and cooperation. This study examined whether mice can perform fine social discrimination,i.e., distinguish between siblings from the same home cage. We found that both male and female C57BL6/J mice can discriminate siblings, regardless of their sex. Notably, this fine social discrimination ability is impaired in mouse model of Alzheimer’s disease (AD) at a very early stage of the pathology,i.e.,at an age when they can still recognize two unrelated mice from different home cages. This suggests that fine social discrimination deficits occur early in AD, and could serve as an early marker of the pathology.
A unified framework for drug–target interaction prediction by semantic-guided meta-path method
Authors: Li Haoyuan , Wang Jianxin , Zhao Haochen , Zheng Kai , Zhao Qichang 
Published: October 2024

AbstractDrug-target interaction (DTI) prediction plays a crucial role in drug development, impacting areas such as virtual screening, drug repurposing, and the identification of potential drug side effects. Despite significant efforts dedicated to improving DTI prediction, existing methods still struggle with the challenges posed by the high sparsity of DTI datasets and the complexity of capturing heterogeneous information in biological networks. To address these challenges, we propose a unified framework for DTI prediction based on a semantics-guided meta-path walk. Specifically, we first pre-train drug and protein embeddings to capture their semantic information. This semantic information is then leveraged to guide a meta-path-based random walk on the biological heterogeneous network, generating sequences of interactions. These sequences are used to compute embedding features via a heterogeneous skip-gram model, which are subsequently fed into downstream tasks to predict DTIs. SGMDTI achieves substantial performance improvement over other state-of-the-art methods for drug–target interaction prediction. Moreover, it excels in the cold-start scenario, which is often a challenging case in DTI prediction. These results indicate the effectiveness of our approach in predicting drug-target interactions.Experimental datasets and experimental codes can be found inhttps://github.com/HYLPRC/SGMDTI
Calcium-modulatedcisandtransE-cadherin EC1-2 interactions play a key role in formation, dynamics and plasticity of cadherin junctions
Authors: Lai-Kee-Him J. , Fouillen A. , Chee M. , Lemercier N. , Feracci H. , Bron P. 
Published: October 2024

ABSTRACTClassical cadherins are ubiquitous calcium-dependent adhesive glycoproteins required in junction formation in metazoans. Calcium ions are essential for cadherin biological activity, but how they act in synergy is still a matter of controversy. We investigated by cryo-electron microscopy and cryo-electron tomography, a biomimetic system consisting of liposomes decorated with the two first E-cadherin extracellular modules, previously reported as functionally essential in junction formation. We showed that E-cadherin extracellular modules 1 and 2 are sufficient to form junctions in presence of calcium. Together with the first adhesive contacts, we observed the formation of cadherin patches and quasi-crystalline structures on the free surface of proteoliposomes suggesting that calcium complexation induces the self-interaction of the E-cadherin extracellular modules 1 and 2 throughcisinteractions. We propose that these calcium-dependent cadherin nanoplatforms, by facilitating the formation frequency oftransinteractions, most probably favor the formation of junctions. We also observed a cooperative effect betweentransandcisinteractions leading to the protein depletion of liposome surfaces. Additionally, Cryo-electron tomography experiments performed on extracellular E-cadherin modules 1 and 2-mediated junctions revealed the coexistence of different molecular arrangements previously described from crystallography studies. Thus, this study provides a new insight into biophysical mechanisms underlying how calcium binding modulates cadherin adhesive function, in showing that E-cadherin 1 and 2 modules play a key role through their intrinsic ability to form multiple calcium-dependentcisandtransinteractions, in the formation of cadherin junctions contributing to the dynamics and plasticity of cadherin-mediated cell junctions.