bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Guided Smartphone App (Vimbo) for the Reduction of Symptoms of Depression and Anxiety in South African Adults: Pilot Quantitative Single-Arm Study
Authors: Steyn Sherrie , Slabbert Meggan 
Published: October 2024

Background
Barriers to mental health assessment and intervention have been well documented within South Africa, in both urban and rural settings. Internationally, evidence has emerged for the effectiveness of technology and, specifically, app-based mental health tools and interventions to help overcome some of these barriers. However, research on digital interventions specific to the South African context and mental health is limited.

Objective
This pilot study investigated the feasibility of using an app (Vimbo) to treat symptoms of anxiety and depression in South African adults recruited from a community sample. The Vimbo app is a self-guided, cognitive behavioral therapy–based digital intervention for common mental health difficulties developed for the South African context.

Methods
This pilot study used a naturalistic, single-arm design testing the Vimbo app over 12 weeks, from October 2020 to February 2021. Participants were recruited through the South African Depression and Anxiety Group and social media advertisements online. A 2-week retention period was used to allow for a minimum of 2 datasets. App usage and engagement metrics were extracted directly from the back end of the app. Based on the model, researchers expected many users to discontinue usage when their symptom levels entered a healthy range. Pre-post review of symptom levels was used to reflect on clinical recovery status at discontinuation after the retention period.

Results
A total of 218 applicants met study eligibility criteria and were invited to download the Vimbo app. Of these, 52% (114/218) of the participants registered with the app, who indicated multiple variances of depression and anxiety symptoms ranging in severity from mild to severe. Two participants users withdrew from the study. Moreover, 69% (77/112) of users were retained, including 8 who had technical issues with their treatment. When comparing broad uptake across all interested participants, chi-square analysis indicated significantly reduced uptake in participants identifying as “unemployed but seeking employment” (χ24=10.47; N=251; P=.03). When considering app usage for the entire cohort (n=69, excluding participants with technical issues), there was a mean of 72.87 (SD 71.425) total module pages read, a mean of 30% (SD 29.473%) of prescribed content completed, and a mean of 19.93 (SD 27.517) times engaging with tools and skills.

Conclusions
Our findings support the case for continued exploration of app-based interventions for treating depression and anxiety in South Africa. Developing strategies to increase access and improve intervention uptake may prove essential to helping mobile health interventions make as significant an impact as possible. Future research should include a randomized controlled trial with a larger sample to further assess the efficacy of app-based interventions in treating mental health difficulties in South Africa.
Age Variation Among US Adults’ Social Media Experiences and Beliefs About Who Is Responsible for Reducing Health-Related Falsehoods: Secondary Analysis of a National Survey
Authors: Galinkala Prathyusha , Atkinson Elise , Campos-Castillo Celeste 
Published: October 2024

Abstract

Background
We live in a digital age where social media has become an essential part of people’s lives. It is also one of the leading platforms responsible for spreading health-related falsehoods. This study explores who adults of different age groups perceive as responsible for reducing health-related falsehoods on social media.

Objective
Despite growing concern over older adults’ exposure to false health information on social media, little research examines their beliefs on how to address the problem. This study examines how the age of US adults is associated with their reported experiences with health-related falsehoods on social media and their beliefs about who should be tasked with reducing such falsehoods.

Methods
This study is a secondary analysis of data from the 2022 Health Information National Trends Survey, a nationally representative survey of US adults (18 years and older). Multivariable logistic regressions estimated how a respondent’s age was associated with their self-reported social media use, their difficulty to detect health-related falsehoods on social media, their discussion of health information found on social media with medical providers, and their beliefs regarding who should be responsible for reducing health-related falsehoods on social media. Regression estimates were adjusted for respondents’ sociodemographic and health characteristics.

Results
Daily social media use decreased with respondents’ age. Respondents aged 50‐64 years (b=0.515, P=.01) and 65‐74 years (b=0.697, P=.002) were more likely than respondents aged 18‐34 years to report they strongly agree that it is difficult for them to detect health-related falsehoods on social media. Compared to younger adults, older adults (65‐74 years: b=0.818, P=.002; 75 years and older: b=1.058, P<.001) were more likely to believe medical providers should be responsible for reducing online falsehoods.

Conclusions
In addition to ongoing efforts by social media platforms to detect and remove falsehoods, the findings suggest medical providers should be tasked with discrediting health-related falsehoods on social media for older adults. However, time during the clinical visit is limited. Future research is needed to discover new approaches and tools tailored to older adults to assist with filtering and discrediting health-related falsehoods on social media.
Extent and Nature of Television Food and Nonalcoholic Beverage Marketing in 9 Asian Countries: Cross-Sectional Study Using a Harmonized Approach
Authors: Karupaiah Tilakavati , Rahman Shah Md Mahfuzur , Zhang Juan , Kumar Naveen , Jamiyan Batjargal , Pokharel Raj Kumar , Borazon Elaine Quintana , Thoradeniya Tharanga , Tho Nguyen Thi Thi , Mackay Sally , Kelly Bridget , Swinburn Boyd , Chinna Karuthan , Dashzeveg Enkhmyagmar , Ong Gild Rick , Narayanan Sreelakshmi Sankara , Sameeha Mohd Jamil , Uddin Mohammad Ahsan , Tang Yuxiang , Sharma Naresh Kumar , Pokharel Rishav , Rome Anna Christine , Wickramasinghe V Pujitha , Huy Phan Thanh 
Published: October 2024

Background
Rising childhood obesity rates in Asia are adding risk for the future adult burden of obesity and noncommunicable diseases. Weak policies across most Asian countries enable unrestricted marketing of obesogenic foods and beverages to children. Television is the common medium for food marketing to reach this audience.

Objective
This study aimed to assess the extent and nature of television food and nonalcoholic beverage marketing in 9 Asian countries (Bangladesh, China, India, Malaysia, Mongolia, Nepal, the Philippines, Sri Lanka, and Vietnam) with capacity building support from the International Network for Food and Obesity/Non-Communicable Disease Research, Monitoring and Action Support, who enabled harmonization of data collection method and content analyses.

Methods
Advertised foods were categorized as permitted or not permitted based on the nutrient profile models established by the World Health Organization regional offices for South-East Asia (SEARO) and the World Health Organization regional offices for Western Pacific (WPRO). Overall rates of food advertisements (advertisements per hour per channel) and persuasive strategy use were analyzed along with comparisons between children’s peak viewing time (PVT) and non-PVT.

Results
Cross-country comparisons, irrespective of country income level, indicated that not permitted food advertising dominated children’s popular television channels, especially during PVT with rates as per WPRO or SEARO criteria ranging from 2.40/2.29 (Malaysia) to 9.70/9.41 advertisements per hour per channel (the Philippines). Persuasive strategy rates were also comparatively higher during PVT. Sugar-sweetened beverages, sugar-containing solid foods, and high salt- and fat-containing snacks and fast foods were frequently advertised. Evaluation of the application of WPRO and SEARO nutrient profile models identified inconsistencies due to regional taste and cuisine variations across Asia.

Conclusions
This study clearly showed that unhealthy food marketing through popular children’s television channels is widely occurring in Asia and is a clear breach of child rights. Evidence outcomes will benefit advocacy toward stronger policy regulations to control unhealthy food marketing and strengthen strategies to promote a healthier food environment for Asia’s children.
Web-Based Parent Training With Telephone Coaching Aimed at Treating Child Disruptive Behaviors in a Clinical Setting During the COVID-19 Pandemic: Single-Group Study With 2-Year Follow-Up
Authors: Sourander Saana , Westerlund Minja , Baumel Amit , Hinkka-Yli-Salomäki Susanna , Ristkari Terja , Kurki Marjo , Sourander Andre 
Published: October 2024

Abstract

Background
There is a lack of studies examining the long-term outcomes of web-based parent training programs implemented in clinical settings during the COVID-19 pandemic.

Objective
The aim is to study 2-year outcomes of families with 3‐ to 8-year-old children referred from family counseling centers to the Finnish Strongest Families Smart Website (SFSW), which provides digital parent training with telephone coaching aimed at treating child disruptive behaviors.

Methods
Counseling centers in Helsinki identified fifty 3‐ to 8-year-old children with high levels of disruptive behavioral problems. Child psychopathology and functioning as well as parenting styles and parental mental health were collected from parents at baseline; posttreatment; and at 6-, 12-, and 24-month follow-ups.

Results
The SFSW program had positive long-term changes in child psychopathology and parenting skills. Improvements in child psychopathology, including Strengths and Difficulties Questionnaire total score (Cohen d=0.47; P<.001), Strengths and Difficulties Questionnaire conduct scores (Cohen d=0.65; P<.001), and Affective Reactivity Index irritability scores (Cohen d=0.52; P<.001), were maintained until the 24-month follow-up. Similarly, changes in parenting skills measured with the Parenting Scale, including overreactivity (Cohen d=0.41; P=.001) and laxness (Cohen d=0.26; P=.02), were maintained until the 24-month follow-up. However, parental hostility changes were not maintained at long-term follow-up (Cohen d=−0.04; P=.70).

Conclusions
The study shows that the SFSW parent training program can yield significant long-term benefits. Findings indicate that the benefits of the treatment may vary between different parenting styles, which is important to consider when developing more personalized parenting interventions.
Identification of prognostic biomarkers of chromatin remodeling in acute myeloid leukemia based on TCGA data analysis (Preprint)
Authors: LIU LANXIANG , ZHANG HONGBIN , WANG LI , LIU LIN , Yan Xinyu 
Published: October 2024

BACKGROUND

Acute myeloid leukemia (AML) is a malignancy of the blood system. The commonly altered regions in the genome of AML encompass a multitude of gene modifications associated with epigenetic regulation. However, the prognostic significance of chromatin remodeling-related genes (CRRGs) as an overall indicator has yet to be assessed in AML.

OBJECTIVE

The purpose of our analysis results was to establish a solid theoretical foundation for the clinical treatment of AML.

METHODS

Uunivariate Cox regression analysis was performed for CRRGs. The Differential expressed genes (DEGs) between chromatin remodeling related AML subtypes in TCGA-AML were measured. CIBERSORT and ssGSEA algorithms were employed to compare disparities in immune responses. GSVA analysis was performed and tumor mutation burden (TMB) analysis was conducted. Using TIDE to assess patients' differences in sensitivity to immunotherapy. The construction and verification of the nomogram were carried out. Expression of biomarkers in healthy and AML patients was analyzed by RT-qPCR.

RESULTS

In TCGA-AML, a total of 3995 differential genes were identified. There were differences between two AML clusters in T cells CD4 memory activated and Dendritic cells activated. A total of 6 prognostic biomarkers were identified, namely ARF6, ASF1B, CHD5, FLNA, KDM5B, and SPI1. The high-risk group exhibited higher TIDE scores. A total of 29 drugs had lower IC50 values in high-risk group. We found that risk score was an independent prognostic factor for AML.RT-qPCR results showed significant differences in expression of ARF6, KDM5B and CHD5 between healthy and AML patients.

CONCLUSIONS

We identified six biomarkers, namely ARF6, ASF1B, CHD5, FLNA, KDM5B, and SPI1, thereby establishing a theoretical foundation for clinical diagnosis of AML.
Ethnomathematics: Exploration of Mathematical Concepts on the Process of Madurese Salt Production
Authors: Hanik Umi , Efendy Makhfud , Jannah Ana Naimatul , Fatmawati Ira 
Published: October 2024

The exploration of mathematical concepts as a human activity triggers the need to research ethnomathematics. This research is the analysis of fundamental activities of mathematics on the process of Madurese Salt Production in Pamekasan. This qualitative study was conducted using ethnography, and the data were obtained from conducting in-depth interviews and observations with some salt farmers. The analysis findings of fundamental activities of mathematics on the process of Madurese Salt Production are: 1) locating: choosing pond location based on the soil, water, and weather; 2) designing: designing the layout of brine pond and considering the plots based on the functions; 3) measuring: measuring the seawater concentration, the level of the water as raw materials, the thickness of salt crystals, the plots, and; 4) counting: calculating workers' wage and profit and loss; 5) playing, solving unpredictable weather to be able to be; and 6) explaining: the salt farmers shared hereditary knowledge about windmill. The results can be used as a source for the development of teaching materials in mathematics learning based on ethnomathematics on the process of Madurese salt production.
Sidestream dark field video microscopy demonstrates shelf-stable blood products preserve the endothelial glycocalyx in a canine hemorrhagic shock model
Authors: Ryan Mark A. , Ford Rebekah , Ewer Nicole , Hall Kelly E. , Guillaumin Julien , Edwards Thomas H. , Venn Emilee C. , Grantham Lonnie E. , Hoareau Guillaume L. 
Published: October 2024

Abstract

OBJECTIVE
To utilize sidestream dark field video microscopic technology to evaluate the endothelium in a canine hemorrhagic shock and resuscitation model.

METHODS
6 purpose-bred adult dogs were anesthetized, instrumented, and subjected to hemorrhagic shock from September 2021 through June 2022. Each dog was resuscitated with 5 resuscitation strategies in an experimental crossover design study: (1) lactated Ringer’s solution (LRS) and hydroxyethyl starch (HES) solution; (2) canine chilled whole blood (CWB); (3) canine fresh frozen plasma (FFP) and packed RBCs (pRBC); (4) canine freeze-dried plasma (FDP) and hemoglobin-based oxygen carrier (HBOC); or (5) HBOC/FDP and canine lyophilized platelets. Sidestream dark field video microscopic evaluation was performed at 5 time points: commencement, after hemorrhage, after shock, after resuscitation (T135), and conclusion (T180).

RESULTS
There was a significant difference between the perfused boundary region (PBR) measurements when comparing the LRS/HES resuscitation arm to the CWB and FFP/pRBC resuscitation arms at T180. A significant difference in PBR was appreciated in the LRS/HES arm at T135 and T180 compared to its baseline. No other significant differences in PBR were appreciated when resuscitation arms were compared longitudinally or to each other.

CONCLUSIONS
Shelf-stable blood products preserved the endothelial glycocalyx similarly to CWB and pRBC/FFP as evaluated by sidestream dark field video microscopy. Lactated Ringer and HES solutions did not adequately preserve the endothelial glycocalyx compared to CWB and pRBC/FFP.

CLINICAL RELEVANCE
Shelf-stable blood products are a viable option to preserve the endothelial glycocalyx when used during hemorrhagic resuscitation in dogs.
Investigating the Interrelationship between the Desire for a Cohesive Community and Opioid Abuse: A Neuropsychological Study of Demon Copperhead
Authors: Sam Lemon 
Published: October 2024

Abstract
Foregrounding the increasing global crisis of opioids as the “leading cause of deaths in fatal overdoses,” the World Drug Report 2023, published by the United Nations Office on Drugs and Crime (UNODC), mentioned that in 2021 more than 80,000 people died due to opioid overdose in the United States of America. The Centers for Disease Control and Prevention (CDC), the national public health protection agency in the United States, has reported that “the predicted number of drug overdose deaths showed an increase of 0.5% from the 12 months ending in December 2021 to the 12 months ending in December 2022, from 109,179 to 179,680” (“Provisional Data”). Although the trajectory of opioid use disorders (OUDs) has affected different sociodemographic groups in the country since its first wave in the 1990s, teenagers in poverty-stricken rural areas are more vulnerable to such addiction (Keyes et al.). Poor parental guidance, impoverishment, troubled childhoods, detrimental familial structure, scarce opportunities, and accessibility to opioids are often considered to be the primary risk factors for unprivileged teenagers to develop a psychic reliance on opioids for engendering a perpetual sense of contentment. According to the incentive sensitization theory, the persistent desire to transcend physical and psychical limitations for a sense of relief, triggered by chronic drug misuse, often evokes a sense of “wanting” or incentive salience, a compulsive inclination towards drug-associated stimuli (Berridge and Robinson, “Drug Addiction” 22). This intense desire of “wanting” often generates a perpetual sensitization of the mesolimbic systems in the brain which is also activated by mental representations of drug-associated cues (Robinson and Berridge 3139). Focusing on drug-induced changes in the brain such as hypersensitization and neuroadaptation, this study analyzes Barbara Kingsolver’s Demon Copperhead, a modern reimagining of David Copperfield by Charles Dickens. The selected text addresses primarily some pertinent socio-political crises, such as the poor foster care system, poverty, and the engrossing opioid endemic in Southern Appalachia. However, this study attempts to analyze the precarious state of some characters, who become addicted to opioids seeking recognition from peer groups and perpetual psychic stability, in the selected text from a neuropsychological perspective.
Recovered History: Chicanx Representation in the Dual Credit Classroom
Authors: Stephens Ronnie K. 
Published: October 2024

Abstract
Recent legislation in Texas effectively prohibits K-12 educators from addressing issues of racism and explicitly prevents teachers from discussing the place of racism in Chicanx relations across Texas history. University educators, and dual-credit instructors especially, must intercede if future generations of learners are going to encounter the true and complete history of border culture, colonialism, and the complex relationship that Chicanx people have with the Southern region of the United States. I argue that the use of digital archives and recovered history like the internet project Are We Good Neighbors? Mapping Discrimination Against Mexicans in 1940s Texas, which catalogs racial discrimination through individual testimony, the Library of Congress database of Mexican American documents, and Chicano! History of the Mexican American Civil Rights Movement offer educators an opportunity to incorporate key research skills into the classroom while also establishing a linear context for liminality as a feature of identity formation in contemporary Chicanx literature. The combination of research and critical inquiry is vital to instructing students on the realities of Chicano relations and introducing them to the Mexican American Civil Rights Movement, a key element of American history that is not only conspicuously absent from most K-12 curricula but also an inescapable influence on identity formation and contemporary discussions around Mexican American relations. The use of digital archives to recover and center Chicanx history is actionable on a small scale and serves as an important opportunity to resist anti-ethnic legislation in real time, a vital act of subversion that sidesteps prolonged challenges to censorship at the legislative level.
Teaching the January 6th Insurrection: Historical Perspectives on a Crisis in American Democracy
Authors: Fure-Slocum Eric 
Published: October 2024

Abstract
This article offers a framework for analyzing and teaching the January 6, 2021, insurrection at the US Capitol. The crisis itself offers an opportunity to unpack and better understand American political discourses and institutions. I focus on four historical and contemporary currents that elucidate the January 6th crisis: 1) White supremacy and backlashes against Civil Rights; 2) conservative assaults on the New Deal order and the regulatory state; 3) organized labor’s decline, right-wing populism’s rise, and nativism; 4) political polarization, sectarianism, and minority rule. These themes enable students to assess both crucial challenges posed by January 6th and the vitality of American democracy.
Soil health of bananas cultivated in Ribeira River Valley – the major producing region of Brazil
Authors: Cavalieri-Polizeli Karina Maria Vieira , da Silva Anderson Lucas , Cremonesi Marcus , Lima Juliana Domingues , Cipriano Patriciani Estela , Cherubin Maurício Roberto , Rozane Danilo Eduardo 
Published: October 2024

ABSTRACT
Soil health receives the increased attention of researchers worldwide to evaluate the sustainability of agricultural land management. Chemical, physical and biological indicators are essential to reflect the soil functioning capacity and its quality. Thus, the aim of this study was to determine the soil health and quality of banana crops compared with natural forests. The experimental area included three counties: Eldorado, Registro and Sete Barras, located in Baixo Vale do Ribeira, in the state of São Paulo, Brazil. In each county, soil from banana orchards was compared with soil collected from the natural Atlantic Forest in the transitional regeneration phase, in split-plot design, considering each county as a block. Soil health was evaluated through six soil quality indexes developed using different strategies to define the minimum dataset, data interpretation (linear or non-linear scoring curves) and integration (additive or weighted). Compared with natural forests, in general, banana crop soil showed elevated values of the chemical indicators, mainly due to the frequent fertiliser applications. A slight decrease, but still adequate, of physical indicators, primarily related to soil aeration and similar results in biological indicators. All soil quality indexes tested here can be used to verify soil health; however, soil quality index-2 was the best for a total dataset, and soil management assessment framework was the best for a minimum dataset, demonstrating no statistical difference in soil health between banana and forest soil systems.