bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of cerebellar FOXP1 in the development of motor and communicative behaviors in mice
Authors: Chasse R. , McLeod R. , Surian A. , Fitch R. H. , Li J. 
Published: October 2024

AbstractThe gene FOXP2 is well established for a role in human speech and language; far less is known about FOXP1. However, this related gene has also been implicated in human language development as well as disorders associated with features of autism spectrum disorder (ASD). FOXP1 protein expression has also recently been identified in the cerebellum—a neural structure previously shown to express FOXP2 protein. The current study sought to elucidate the behavioral implications of a conditional knock‐out of Foxp1 using an En1‐Cre driver, which is active in the entirety of the cerebellum and a subset of neurons in the midbrain and spinal cord, in mice using a test battery including motor tasks associated with cerebellar dysfunction, as well as communicative and autistic‐relevant behaviors. Male and female mice with a conditional knock‐out (cKO, n = 31) and wildtype littermate controls (WT, n = 34) were assessed for gross and orofacial motor control, motor‐coordination learning, locomotion, social behavior, anxiety, auditory processing and expressive vocalizations. Overall results suggest Foxp1 plays a specific role in the development of communicative systems, and phenotypic expression of disruptions may interact with sex. Robust motor deficits associated with Foxp1 protein loss may particularly affect vocalizations based on significant orofacial motor deficits in cKO subjects could also contribute to vocalization anomalies. In summary, the current study provides key insights into the role of Foxp1 in cerebellar function and associated behaviors in mice, with implications for an improved understanding of communicative and motor‐based neurodevelopmental disabilities in humans.
Nurses' Perceptions and Behaviours Regarding Climate Change and Health: A Quantile Regression Analysis
Authors: Park Min Kyung , Baek Seoyoung , Jeong Da Woon , Kim Gwang Suk 
Published: October 2024

ABSTRACTAimsThe aim of this study is to identify the factors associated with nurses' perceptions and behaviours related to climate change and health (PBCH) according to their PBCH levels.DesignA cross‐sectional study was used.MethodsThis study included a sample of 499 Korean nurses and adhered to the STROBE checklist. Data were collected from March 23 to May 10, 2023. Quantile regression analysis was performed, and PBCH levels were measured using the Korean version of the Climate Health and Nursing Tool.ResultsAcross all quantile groups, the experience of extreme weather events and awareness of climate change‐coping facilitators were associated with PBCH. Differences were observed in factors associated with PBCH levels. Significant associations with PBCH were observed within the 75th percentile group, for having a religion, household income, and workplace climate friendliness. In the 25th percentile group, having a child, the number of sources for climate change–health‐related information, and experience in setting climate change–health goals and strategies significantly influenced PBCH.ConclusionWe propose a differentiated strategy by elucidating the factors associated with high and low quantiles of PBCH levels.ImplicationsBy verifying specific factors associated with PBCH levels, nurses can enhance their preparedness to respond to the health risks posed by climate change in their clients.ImpactIdentifying common factors associated with all quantiles of nurses is important for establishing universal PBCH characteristics. Recognising the distinctions between high and low PBCH levels can aid in developing tailored nursing strategies to enhance PBCH among nurses.Reporting MethodThis study adhered to the STROBE guidelines.Patient or Public ContributionNo Patient or Public Contribution.
Contact allergic dermatitis to skin adhesive after CIED upgrade procedure
Authors: Raja Kishore Raja , Bigliardi Paul , Dugas Brenda , White Michael , Jimenez Erick , Clark Bradley C. 
Published: October 2024

AbstractIntroductionThe utilization of skin adhesives for closure is typically secondary to its noninvasive application and aesthetic benefits. Allergic reactions to Dermabond™ can occur, though there are no reported cases in pediatric patients following cardiac implantable electronic device (CIED) implantation. The allergic reaction to skin glues is typically to cyanoacrylates, the primary component of Dermabond™.Methods and ResultsThis report describes severe allergic contact dermatitis due to sensitization to cyanoacrylate in an 18‐year‐old with repaired congenital heart disease and postoperative atrioventricular block following CIED upgrade procedure.ConclusionThis demonstrates the importance of prompt diagnosis of allergic contact dermatitis, which can be confused with local infections.
Kui‐Jie‐Ling capsule inhibits ulcerative colitis by modulating inflammation and gut microbiota
Authors: Li Kun , Guo Lengqiu , Yu Jinghua , Yang Yun , Wei Lan , Min Chunyan , Xu Xinkang , Li Fang , Liu Jiangyun , Zhou Guangquan , Zhang Jian 
Published: October 2024

AbstractBackground and AimKui‐Jie‐Ling capsule (Kui‐Jie‐Ling) is a hospital preparation for ulcerative colitis (UC) in China. This study aimed at evaluating the protective effects and mechanisms of Kui‐Jie‐Ling and Kui‐Jie‐Ling combined with adalimumab on UC induced by dextran sulfate sodium (DSS).MethodsNetwork pharmacology was combined with an animal experiment to reveal the targets of Kui‐Jie‐Ling alleviating UC. The UC model was established by drinking 2.5% DSS solution for 7 days. On the second day, the mice in the Kui‐Jie‐Ling group were orally administered with Kui‐Jie‐Ling (1.5 and 3.0 g/kg) daily for seven consecutive days, and the mice in the combination group were orally administered with Kui‐Jie‐Ling (3.0 g/kg) once a day for seven consecutive days and received one subcutaneous injection of adalimumab. The disease activity index, the colon length, the spleen index, the cytokines, the colon, the short‐chain fatty acid content, and the gut microbiota in the colon were analyzed. The role of gut microbiota against UC was verified by fecal microbiota transplantation experiments.ResultsThe animal study's results were consistent with the network pharmacology analysis, which reflected that Kui‐Jie‐Ling alleviated UC via multi‐pathway. Kui‐Jie‐Ling ameliorated UC by inhibiting the formation of neutrophil extracellular traps (NETs), regulating inflammatory factors through the lipopolysaccharide–toll‐like receptor 4/nuclear factor kappa B and interleukin‐23–Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway, and restoring intestinal homeostasis.ConclusionThese studies provided the experimental basis for the clinical administration of Kui‐Jie‐Ling and Kui‐Jie‐Ling combined with adalimumab against UC.
HOS1 ubiquitinates SPL9 for degradation to modulate salinity‐delayed flowering
Authors: Jiao Zhixin , Shi Xiaoning , Xu Rui , Zhang Mingxia , Chong Leelyn , Zhu Yingfang 
Published: October 2024

ABSTRACTSoil salinity is a serious environmental threat to plant growth and flowering. Flowering in the right place, at the right time, ensures maximal reproductive success for plants. Salinity‐delayed flowering is considered a stress coping/survival strategy and the molecular mechanisms underlying this process require further studies to enhance the crop's salt tolerance ability. A nuclear pore complex (NPC) component, HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 (HOS1), has been recognized as a negative regulator of plant cold responses and flowering. Here, we challenged the role of HOS1 in regulating flowering in response to salinity stress. Interestingly, we discovered that HOS1 can directly interact with and ubiquitinate transcription factor SPL9 (SQUAMOSA PROMOTER BINDING PROTEIN‐LIKE 9) to promote its protein degradation in response to salinity stress. Moreover, we demonstrated that HOS1 and SPL9 antagonistically regulate plant flowering under both normal and salt stress conditions. HOS1 was further shown to negatively regulate the expression of SPLs and several key flowering genes in response to salinity stress. These results jointly revealed that HOS1 is an important integrator in the process of modulating salinity‐delayed flowering, thus offering new perspectives on a salinity stress coping strategy of plants.
Evaluating the Effectiveness of Probiotic Supplementation in Combination With Doxycycline for the Treatment of Moderate Acne: A Randomized Double‐Blind Controlled Clinical Trial
Authors: Atefi Najmolsadat , Mohammadi Masoumeh , Bodaghabadi Mohammad , Mehrali Marjan , Behrangi Elham , Ghassemi Mohammadreza , Jafarzadeh Alireza , Goodarzi Azadeh 
Published: October 2024

ABSTRACTBackgroundAcne is a chronic inflammatory skin disease that negatively affects patients' quality of life. Increasing antibiotic resistance is making acne less responsive to treatment. Probiotics are live microorganisms that can provide health benefits by fighting pathogens and maintaining intestinal homeostasis and skin microbiome balance. This study investigates the effects of probiotics in the treatment of acne vulgaris.MethodsIn this randomized controlled clinical trial, 80 patients with moderate acne were divided into two groups of 40. All patients received the same topical treatment, which consisted of a daily antibacterial face wash and Adapalene gel every other night. The control group received one capsule of doxycycline (100 mg) daily, whereas the intervention group received one probiotic capsule daily in addition to doxycycline. Patients underwent photography of facial acne lesions, and treatment response was assessed using the global acne grading system (GAGS) and acne grading method at baseline, as well as during follow‐up visits at 1, 2, and 3 months.ResultsThe global acne grading system indicated that both groups showed improvement. However, analyses revealed that outcomes were significantly better in the doxycycline plus probiotics group for the forehead (p = 0.018), chin (p = 0.021), and nose (p = 0.021). No significant differences were observed for the left and right cheeks, back, and chest areas, with the mean GAGS score reduction between the two groups differing by only 2%. Treatment with probiotics significantly reduced the severity of lesions compared to the control group (p < 0.001). The acne grading method also indicated that the intervention group had a significantly better treatment response than the control group (p < 0.001). Furthermore, treatment with probiotics did not result in any side effects.ConclusionProbiotics can serve as an effective and safe treatment option, enhancing the outcomes of routine acne treatments, particularly for patients with acne on the forehead, chin, and nose.
Melasma Revisited: National Survey Reveals How Dermatologists Diagnose and Treat This Complex Skin Condition
Authors: Hizli Pelin , Kiliç Fatma Arzu , İçöz Aytaç Seyma 
Published: October 2024

ABSTRACTBackgroundMelasma is a chronic condition characterized by dark patches on the facial skin. It has a known female gender dominancy, and women usually think of melasma as being a serious cosmetic problem. Treatment of melasma can be seriously challenging, thus, dermatologists may employ different approaches for melasma. This study aimed to investigate how dermatologists diagnose and treat patients with melasma and to present the general characteristics of patients with melasma.MethodsA survey was conducted using Google Forms targeting dermatologists in Turkiye. A total of 199 dermatologists (142 females/57 males) participated in the study.ResultsMost of the participants (52.3%) were residents. Majority gender of the patients was female and most common age range of patients with melasma was 30–40 years. Mixed melasma was the most common type (57.4%). Malar region was the most frequent location (58.6%). Wood's lamp examination was used by 25.6% of the participants. Topical treatment was the first‐line choice for melasma therapy (95%), with Kligman's formula being the most used topical agent (69.8%). Oral therapy was not used by 70.8% of the participants. Tranexamic acid was the first choice for oral treatment (23.4%). Only 24.9% of the dermatologists used laser/light therapy, and Q‐switched Nd‐YAG laser was the most preferred device (58%). The most common recurrence rate was 41%–60% (45.9%).ConclusionsThe findings of the current study investigating the melasma management in Turkiye revealed a female predominance and peak prevalence in the 30–40 years age group. Kligman's formula is the preferred topical treatment, whereas oral tranexamic acid remains underutilized. Recurrence rates are high, highlighting the need for preventative strategies. This study emphasizes the importance of personalized approaches and ongoing research for effective melasma management.
Oral Health Related Factors Predicting Severe COVID‐19 Disease in Elderly Swedes
Authors: Johansson Ann‐Katrin , Omar Ridwaan , Lehmann Sverre , Sannevik Josefin , Mastrovito Berit , Johansson Anders 
Published: October 2024

ABSTRACTObjectivesTo analyse different background factors that may serve as predictors for acquiring symptoms of severe COVID‐19 disease.MethodsA postal questionnaire was sent to the total population of individuals born between 1942 (80 years, n = 6299) and 1932 (90 years, n = 1904) living in the Örebro and Östergötland counties, Sweden, in 2017 and repeated in 2022. Tentative predictive factors for self‐reported severe COVID‐19 disease were based on the responses from the 2017 questionnaire related to general and oral health and prior to the outbreak of the COVID‐19 pandemic.ResultsResponse rate to the main questionnaire in 2022 was 66% (5375/8203), and 577 reported having been sick with COVID‐19 out of which 359 agreed to answer a separate questionnaire on COVID‐19. This questionnaire was returned by 278/359 of the participants corresponding to a response rate of 77%. Information gleaned from the 2017 pre‐COVID‐19 survey revealed a relatively large number of associations between severity of subsequently self‐reported COVID‐19 disease and several diverse tentative related factors found in unadjusted regression analyses. Based on statistically significant correlations in the adjusted regression analysis, significant predictive factors (based on self‐reports from 2017) for contracting severe COVID‐19 were in decreasing order of odds ratios (OR): reported removable partial or complete denture usage (OR 6.2, CI 2.2–17.2); reported periodontal problems in the past year (OR 3.4, CI 1.1–10.4); and reported daytime dry mouth (OR 2.5, CI 1.2–5.2).ConclusionRemovable dentures, periodontal problems and daytime dry mouth were predictors for developing symptoms of severe COVID‐19 disease.
Unleashing Leaders' Innovative Work Behavior in Energy Company: The Role of Business Acumen and Innovative Self‐Efficacy
Authors: Iswahyudi Didik , Etikariena Arum 
Published: October 2024

AbstractInnovation is crucial for the sustainability of a company, hence innovative work behavior among its members, including leaders, is key. It is posited that an individual's comprehension of the various business dimensions of their job can lead them to exhibit innovative work behavior. Previous research indicates that innovative self‐efficacy is a strong predictor of such behavior. This study aims to examine the role of innovative self‐efficacy in mediating the effect of business acumen on innovative work behavior. Participants in this study were leaders at PT A, the company in the energy sector that is also tasked with overseeing the energy transition in Indonesia (n = 244). The result shows that innovative self‐efficacy partially mediates the effect of business acumen on innovative work behavior. These findings can provide alternative directions for developing more precise innovation‐oriented leadership preparation programs.
Unveiling interactions mediated by B vitamins between diatoms and their associated bacteria from cocultures
Authors: Costas‐Selas Cecilia , Martínez‐García Sandra , Pinhassi Jarone , Fernández Emilio , Teira Eva 
Published: October 2024

AbstractUnveiling the interactions among phytoplankton and bacteria at the level of species requires axenic isolates to experimentally demonstrate their mutual effects. In this study, we describe the interactions among the diatoms Pseudo‐nitzschia granii and Chaetoceros tenuissimus and their associated bacterial species, isolated from surface water of a coastal upwelling system using coculture experiments. Microalgae growth was assessed in axenic monocultures or in coculture with each of their co‐isolated bacteria in the presence or absence of B vitamins. Pseudo‐nitzschia granii growth was limited by B‐vitamin supply, except when cultured with the bacteria Jannaschia cystaugens, which seemed to provide adequate levels of B vitamins to the diatom. Chaetoceros tenuissimus growth was reduced in the absence of B vitamins. Moreover, the growth of C. tenuissimus was stimulated by Alteromonas sp. and Celeribacter baekdonensis during the exponential growth. These results show a diversity of specific interactions between the diatoms and co‐isolated bacteria, ranging from allelopathy to commensalism. Understanding how interactions between phytoplankton and bacteria modulate the structure and function of marine microbial plankton communities will contribute to a greater knowledge of plankton ecology and improve our ability to predict nutrient fluxes in marine ecosystems or the formation of blooms in a context of global change.
Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD
Authors: Petta Salvatore , Armandi Angelo , Bugianesi Elisabetta 
Published: October 2024

ABSTRACTBackground and AimsMetabolic dysfunction‐associated steatotic liver disease (MASLD) is a heterogenous clinical and histopathological entity, where multiple metabolic co‐factors are intertwined with high interindividual variability. The impact and severity of each factor (including obesity and type 2 diabetes) define a systemic dysmetabolism that can lead to either advanced liver disease and its complication (including hepatocellular carcinoma and clinical events related to portal hypertension) or extrahepatic events: incident cardiovascular disease, chronic kidney disease and extrahepatic cancers. The balance between environmental factors and genetic susceptibility has unique implications in MASLD: the intermittent injury of metabolic co‐factors, their fluctuation over time and their specific management, are counterbalanced by the presence of gene variants that can significantly impact the disease at multiple levels. The I148M variant in the PNPLA3 gene is the most investigated genetic susceptibility that induces a more severe steatohepatitis, enhanced fibrogenesis and can shape the incidence of long‐term clinical events regardless of, or worsened by, other metabolic risk factors.Methods and ResultsIn this review, we will summarise the updated evidence on the natural history of MASLD accounting for classical metabolic risk factors, the role of PNPLA3 in clinical sub‐phenotyping (e.g., ‘lean MASLD’), impact on disease severity and fibrosis progression, as well as its role for prognostication, alone or in combination with non‐invasive tools into polygenic risk scores.
Tackling nonlinear price impact with linear strategies
Authors: Brokmann Xavier , Itkin David , Muhle‐Karbe Johannes , Schmidt Peter 
Published: October 2024

AbstractEmpirical studies in various contexts find that the price impact of large trades approximately follows a power law with exponent between 0.4 and 0.7. Yet, tractable formulas for the portfolios that trade off predictive trading signals, risk, and trading costs in an optimal manner are only available for quadratic costs corresponding to linear price impact. In this paper, we show that the resulting linear strategies allow to achieve virtually optimal performance also for realistic nonlinear price impact, if the “effective” quadratic cost parameter is chosen appropriately. To wit, for a wide range of risk levels, this leads to performance losses below 2% compared to a numerical algorithm proposed by Kolm and Ritter, run at very high accuracy. The effective quadratic cost depends on the portfolio risk and concavity of the impact function, but can be computed without any sophisticated numerics by simply maximizing an explicit scalar function.
DNA methylation‐array interlaboratory comparison trial demonstrates highly reproducible paediatric CNS tumour classification across 13 international centres
Authors: Chirica Mihaela , Jurmeister Philipp , Teichmann Daniel , Koch Arend , Perez Eilís , Schmid Simone , Simon Michèle , Driever Pablo Hernáiz , Bodden Carina , van Tilburg Cornelis M. , Hardin Emily C. , Lavarino Cinzia , Hench Jürgen , Scheie David , Cryan Jane , Vicha Ales , Buttarelli Francesca R. , Michiels An , Haberler Christine , Barahona Paulette , Tops Bastiaan B. J. , Jacques Tom , Stokland Tore , Witt Olaf , Jones David T. W. , Capper David 
Published: October 2024

AbstractAimsDNA methylation profiling, recently endorsed by the World Health Organisation (WHO) as a pivotal diagnostic tool for brain tumours, most commonly relies on bead arrays. Despite its widespread use, limited data exist on the technical reproducibility and potential cross‐institutional differences. The LOGGIC Core BioClinical Data Bank registry conducted a prospective laboratory comparison trial with 12 international laboratories to enhance diagnostic accuracy for paediatric low‐grade gliomas, focusing on technical aspects of DNA methylation data generation and profile interpretation under clinical real‐time conditions.MethodsFour representative low‐grade gliomas of distinct histologies were centrally selected, and DNA extraction was performed. Participating laboratories received a DNA aliquot and performed the DNA methylation‐based classification and result interpretation without knowledge of tumour histology. Additionally, participants were required to interpret the copy number profile derived from DNA methylation data and conduct DNA sequencing of the BRAF hotspot p.V600 due to its relevance for low‐grade gliomas. Results had to be returned within 30 days.ResultsHigh technical reproducibility was observed, with a median pairwise correlation of 0.99 (range 0.94–0.99) between coordinating laboratory and participants. DNA methylation‐based tumour classification and copy number profile interpretation were consistent across all centres, and BRAF mutation status was accurately reported for all cases. Eleven out of 12 centres successfully reported their analysis within the 30‐day timeframe.ConclusionOur study demonstrates remarkable concordance in DNA methylation profiling and profile interpretation across 12 international centres. These findings underscore the potential contribution of DNA methylation analysis to the harmonisation of brain tumour diagnostics.