bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigate the predictivity of human Reconstructed Intestine Micronuclei Cytome (RICyt) assay in genotoxic hazard identification
Authors: Lim Hui Kheng , Hughes Christopher Owen , Landry Timothy , Tan Choon Wee Joseph , Ayehunie Seyoum , Smith Benjamin Paul Chapman 
Published: September 2024

Abstract

While valuable for hazard identification, in vitro genotoxicity tests that are conducted in 2D monolayer cell cultures possess limitations to accurately envisage in vivo outcomes and may result in unnecessary follow-up in vivo studies. One limitation is their relevance to actual human exposure and the assessment of genotoxicity in tissues representative of “sites-of-first-contact” with genotoxic agents. The revised OECD testing guidelines had emphasized the need for considering site-of-first-contact effect and should be included when carrying out genotoxic hazard investigations. Till date, only in vivo studies can adequately address the oral/gastrointestinal route of exposure and there exists no validated in vitro assay for the gut for ingestible materials. Previously, we described the development of a new human Reconstructed Intestine Micronuclei Cytome (RICyt) assay using EpiIntestinal™ microtissues for site-of-contact genotoxic hazard identification of orally ingested materials. The human small intestine is where approximately 90% of the digestion and adsorption of food occurs and a major exposure site of ingested genotoxicants, thus a key site for evaluation. Here, we have conducted an investigation on the predictive performance of the RICyt assay. The assay platform was challenged with a training set of 16 test materials which include standard reference genotoxins and non-genotoxins as well as food relevant substances with various mode of actions. The overall RICyt accuracy was 92.9% with sensitivity of 83.3% and specificity of 100%. Majority of the test materials were correctly identified during this within-laboratory investigation though yielded one false negative and two equivocal outcomes. These results emphasize that the RICyt assay in EpiIntestinal™ microtissues has adequate predictivity and is a promising in vitro tool for genotoxic hazard identification of orally ingested substances.
Knowledge, Attitude, and Willingness to accept the RTS, S malaria vaccine among Mothers/Caregivers of under-five children: A Qualitative study in Enugu state, Nigeria
Authors: Iloabuchi Francis Chibuike , Chima Uzochukwu Emmanuel , Umeh Anthony Uche , Okafor Pauline Nnedimma , Ngige Amauche Pearl , Anene-Okeke Chigozie Gloria 
Published: September 2024

Abstract

Background
Malaria remains a significant public health challenge in Nigeria, particularly among children under the age of five. This study investigated the knowledge, attitudes, and willingness to accept the RTS, S malaria vaccine among mothers and caregivers of children under five years of age in Enugu State, Nigeria.
Methods
A descriptive cross-sectional survey design was employed, involving 405 participants who visited two major tertiary hospitals in Enugu State, Nigeria. Data were collected via structured questionnaires, checked, coded, and entered into the Microsoft Excel package 2021 and exported to Statistical Product and Service Solutions (SPSS) version 27 for descriptive and inferential statistical analysis.
Results
A total of 66.2% of the respondents demonstrated good knowledge about malaria and the RTS, S malaria vaccines, whereas only 55.1% exhibited a positive attitude toward vaccination. Despite this, a notable gap was identified, with only 51.6% of participants willing to accept the RTS, S malaria vaccine for their children. Factors significantly influencing vaccine acceptance included the caregiver’s gender, age, marital status, educational level, and place of residence.
Conclusion
These findings highlight the critical need for targeted educational campaigns and interventions to address misconceptions and improve awareness of the benefits and safety of the RTS, S malaria vaccine. Enhancing the knowledge and attitudes of mothers and caregivers is essential to increase vaccine acceptance and ultimately reduce the malaria burden among children in Enugu State. To achieve these goals, collaborative efforts between healthcare providers, government agencies, and community organizations are recommended.
Trial Registration
Not applicable
Using Positive Deviance to Enhance HIV Care Retention in South Africa: Development of a Compassion-Focused Programme to Improve the Staff and Patient Experience
Authors: Ober Allison , Skinner Donald , Bogart Laura , Busakwe Leletu , Davids Wadene , Mahomed Hassan , Ling Debbie , Zweigenthal Virginia 
Published: September 2024

Abstract

Background
HIV burden remains high in South Africa despite intensive efforts to curtail the epidemic. Public primary care facilities, where most people with HIV (PWH) in South Africa receive treatment, face myriad challenges retaining patients on antiretroviral therapy (ART). Nevertheless, some facilities manage to consistently retain PWH in care. We used a participatory Positive Deviance (PD) approach to discover characteristics of primary care facilities with above-average 12-month retention rates to develop an intervention. PD is an asset-based approach to behavior change that consists of discovering how high-performing outliers succeed despite sizable barriers, and then using those data to develop interventions for low-performers.
Methods
We conducted 11 in-depth leadership interviews, 9 staff focus groups with 29 participants, 11 patient focus groups with 45 participants, 23 patient shadowing visits, and 3 clinic observations in each of 3 high- and 3 low-retention public primary care facilities in Cape Town, South Africa, to discover characteristics of high-retention facilities that might be contributing to higher retention rates.
Results
Themes found to a greater degree in high-retention facilities were compassionate, respectful, patient-centered care; higher staff morale, passion for the work and team cohesion; efficient workflow procedures; and a welcoming physical environment. From these themes we developed the Connect intervention, consisting of strategies within three domains: (1) Engage, encourage, and support staff (e.g., a monthly staff support huddle, a compassion training); (2) Expedite and augment workflow procedures (e.g., adjust folder system to lower wait times); (3) Create a welcoming physical environment (e.g., fresh paint and plants in the waiting area).
Conclusions
A PD approach enabled us to identify factors that could be contributing to higher ART retention rates within low-resource public sector primary care facilities in Cape Town, South Africa. If effective, Connect could be a feasible, affordable complement to existing programmes aimed at improving care for PWH.
Toxicity assessment of doxycycline-aided artificial intelligence-assisted drug design targeting candidate 16S rRNA methyltransferase gene
Authors: Mubeen Hira , Rafiq Nagina , Khan Madiha , Jabeen Saima , Shoaib Muhammad Waseem 
Published: September 2024

Abstract

Background
The misfunction of the protein 16SrRNA methyltransferase usually results in Urinary tract (UTI), and Gastrointestinal (GI) infections, sepsis, pneumonia, and also cause wound infections. It confers resistance to aminoglycoside medications, which complicates the treatment of infections caused by these bacteria.
Objectives
Herein, we aim to investigate the role of artificial intelligence (AI) in medical sciences to provide the solutions as a significant need in medical therapy for infections.
Methodology: Using an AI drug design tool, three effective de novo medicinal compounds that target the 16SrRNA methyltransferase protein were discovered. The computational tools used includes: Expasy for protein annotation, Protparam to calculate physiochemical parameters, SWISS-MODEL to estimate the 3D structure, and Uniprot to generate the 16SrRNA methyltransferase protein sequence. An adequate foundation for the development and validation of AI-designed phytochemical medicines for infections is provided by quality assessment, binding site prediction, drug design with WADDAICA, toxicity screening, ADMET evaluation, and docking analysis with CB-dock.
Results
Comprehensive pharmacokinetic and toxicology analyses provided the non-toxic character of AI-designed doxycycline by demonstrating its exceptional absorption in the blood–brain barrier. The AI-designed doxycycline docks with the 16SrRNA methyltransferase protein with a noteworthy affinity of about − 7.6 kcal/mol, indicating potential therapeutic value.
Conclusion
Even though the in silico studies show efficacy and safety, still there is need of in vivo trials to investigate the hidden medical aspects. By addressing existing constraints, this work considerably expands the knowledge about newer methods and also helps to understand deep insights of dug design mechanism for treatment.
Antenna Array and Front End Design for GNSS to Cancel Low Elevation Jamming Signals
Authors: yigit olcay 
Published: September 2024

Abstract

In this study, we propose antenna array and a front-end design to mitigate jamming signals coming from low elevation angles without changing the receiver system. Many navigation systems based on terrestrial signals assume that jamming signals are at low elevation angles. There is a need for a feedback system that detects the presence of interference signals and switches to an interference-resistant mode by activating switches. Signals in the range of 750 MHz to 2 GHz are observed without interference with our designed system. The system receives signals at levels close to -70 dBm for frequencies outside the GNSS band, while signals received within the GNSS band from GPS, Galileo, and GLONASS satellites are close to -130 dBm. Without jamming signals, the C/N value of the received navigation signals is 25–30 dB. When jamming signals are present, C/N values drop to 10 dB. The designed system was tested in both laboratory and open field environments. When the system sense jam signals, it switches to array mode in127 micro seconds, and cancel the jam signals about 30 dB.
Research on Control Strategies for High Center of Gravity, High Curvature 4WS Vehicles on Non-Rigid Pavements
Authors: Yang Xu , Deng Xinxian , Lei Yu , Zhong Shengchi , Huang Bin 
Published: September 2024

Abstract

Autonomous driving technology is not only widely used for open vehicles on municipal roads but also for special equipment in low-speed scenarios such as logistics distribution, sanitation cleaning, sightseeing shuttles, and smart farming. However, in the unique scenarios of farmland and the special structure of unmanned agricultural machinery, autonomous vehicles still face complex control issues such as high curvature steering, non-rigid road surfaces, and high centers of gravity, which severely affect the tracking and stability performance of the vehicles. To address these problems, this paper proposes a path tracking stability control strategy that considers the tracking performance of vehicles during high curvature steering at medium and low speeds, as well as the impact on vehicle stability caused by vehicle tilting due to a high center of gravity and the tendency of vehicles to sink in farmland scenarios. By integrating the Model Predictive Control (MPC) algorithm and improving the fuzzy control algorithm, a 4WS vehicle kinematic model and a lateral stability model under non-rigid road conditions were established. A comprehensive control method that considers vehicle stability and turning path tracking accuracy was proposed. Simulation comparisons using Simulink show that the 4WS vehicle control strategy proposed in this paper has better tracking performance and stability compared to traditional 2W tracking control methods. Experiments conducted on an intelligent driving soil sampling vehicle validated the advantages of the proposed control strategy in terms of high center of gravity, high curvature steering control accuracy, and stability.
A Novel Approach to PMSG-Based Wind Energy Conversion with Power Factor Correction and Efficient DC-DC Conversion
Authors: Sundaramoorthy Selvaperumal , ML Ramamoorthy 
Published: September 2024

Abstract

A novel wind energy conversion system (WECS) utilizing a Permanent Magnet Synchronous Generator (PMSG) followed by an active front end rectifier (AFE) which is followed by a Partial Resonant Inverter (PRI) based AC link DC-DC converter delivering power to DC link of the DSTATCOM is proposed in this work. The control scheme takes care of maximum power point tracking by adjusting speed of PMSG depending upon the prevailing wind velocity. The three phase PMSG side current is forced to be sinusoidal and at unity power factor with respected to the instantaneous PMSG terminal voltage by using the AFE rectifier. This proposed system is discovered to be superior to typical DBR based rectifier in terms of the reduced THD of the source current leading to more power conversion efficiency. PRI exhibit zero voltage switching which offers high voltage gain. This outlined concept is modelled in MATLAB/SIMULINK which has been simulated. The suggested concept is validated by the simulation results.
Next-Gen LH2 Transportation: Extending Dormancy Period to 400 Days with Highly Effective MOF Adsorbents
Authors: Oh Hyunchul , PARK JAEWOO , Ha Junsu , Lee Hong Kyu , Kim Hyunlim , Jung Sungyeop , Jung Minji , Park Taeung , Jiménez-Ruiz Mónica , Russina Margarita , Moon Hoi Ri , Park Jitae 
Published: September 2024

Abstract

Liquid hydrogen (LH2) offers high energy density but faces challenges like boil-off losses (3-15% per day) due to its cryogenic temperature, limiting its use in long-term storage and transportation. In this study, we explore the use of metal-organic frameworks (MOFs), specifically MIL-53 and IRMOF-20, to enhance hy-drogen (H2) long-distance transportation by mitigating H2 boil-off losses. Our results show that these MOFs can achieve an adsorption capacity of up to 97% of the volumetric capacity of a traditional LH2 tank. This significant adsorption capacity extends the dormancy period of LH2 from 83 to 407 days, demonstrating the MOFs' effectiveness in mitigating boil-off losses. The super-dense H2 adsorption, which remains rela-tively stable up to 35 K, may closely resemble the conditions of solid H2, leading to increased H2-H2 inter-actions and enhanced sorption capacity. These findings highlight the potential of MOFs to improve the ef-ficiency and sustainability of cryogenic H2 storage, advancing H2's role as a sustainable energy carrier.
Collaborative Mixture of Experts for Enhanced Code-Switching Visual Recognition Through Recursive Token Propagation
Authors: Nisapo Liam , Garcia Daniel , Williams Olivia , Prence Taylor 
Published: September 2024

Abstract

Multilingual environments often require models to accurately recognize and process both linguistic and visual inputs, particularly in cases where code-switching occurs frequently. Traditional models designed for language and visual recognition struggle to handle such complexities due to their inability to dynamically allocate resources to specific tasks. The introduction of a Collaborative Mixture of Experts (MoE) model within Mistral 8x7b addresses this limitation through the implementation of expert modules that specialize in different aspects of code-switching and visual recognition. A dynamic gating mechanism selects the most appropriate expert based on the input, leading to substantial improvements in precision, recall, and cross-modal accuracy. Experimental results demonstrate that the MoE architecture not only enhances linguistic boundary detection in multilingual contexts but also significantly improves the alignment between language and visual data, ensuring more robust and adaptive performance in real-time applications. The findings indicate that the proposed model outperforms baseline models in both accuracy and computational efficiency, suggesting its potential for further advancements in handling complex multimodal tasks.
PENGARUH MEDIA SOSIAL DAN GAME ONLINE TERHADAP AKHLAK SISWA DI MADRASAH ALIYAH MASYARIQUL ANWAR CARINGIN
Authors: Alauddin Firman , Wasehudin Wasehudin , Haetami Zikri Alwi 
Published: September 2024

Tujuan penelitian ini, untuk mengetahui: (1) Pengaruh media sosial terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin, (2) pengaruh game online terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin, (3) pengaruh media sosial dan game online terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin, Jenis penelitian yang digunakan penelitian ini adalah asosiatif. Teknik pengambilan sampel yang digunakan pada penelitian ini adalah teknik simple random sampling, yaitu teknik pengambilan sampel yang memberikan peluang yang sama bagi setiap unsur (anggota) populasi untuk dipilih menjadi anggota sampel. Selanjutnya untuk mendapatkan pengaruh sosial media dan game online terhadap akhlak siswa peneliti menggunakan pengujian validitas dan reliabilitas yang dilakukan dengan menggunakan software SPSS 26.0. Hasil penelitian menunjukkan bahwa; (1) Hasil pengujian menunjukkan bahwa media sosial berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. Hal tersebut dibuktikan berdasarkan hasil uji t dengan nilai sig sebesar 0,000 < 0,05 sehingga H01 ditolak dan Ha1 diterima. Jadi dapat disimpulkan bahwa media sosial berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. (2) Hasil pengujian menunjukkan bahwa game online berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. Hal tersebut dibuktikan berdasarkan hasil uji t dengan nilai sig diperoleh nilai 0,000 < 0,05 sehingga H02 ditolak dan Ha2 diterima. Jadi dapat disimpulkan bahwa game online berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. (3) Media sosial dan game online berpengaruh terhadap akhlak siswa di Madrasah Aliyah Masyariqul Anwar Caringin. Hal tersebut dibuktikan berdasarkan hasil uji F yang diperoleh nilai 0,000 < 0,05 sehingga H03 ditolak dan Ha3
Electrochemical Behavior of an Anti-cancer Drug Erlotinib at Screen-Printed Electrode and its Analytical Application
Authors: Manjulabhai Pooja Das , Warrier Arun , Raveendran Dr. Jeethu , Gangadharan Dr. Dhanya 
Published: September 2024

Background:
Erlotinib (ERL) is a crucial tyrosine kinase inhibitor utilized for treating
non-small cell lung cancer (NSCLC) and pancreatic cancer. However, due to its significant adverse
effects, precise dosage monitoring is essential throughout treatments.

Methods:
This study developed a sensitive and specific screen-printed electrode (SPE) sensor to
detect erlotinib in human serum, urine, and pharmaceutical dosage forms. The sensor's linear response
range, limit of detection (LOD), and limit of quantification (LOQ) were determined. Additionally,
the sensor's selectivity was assessed by studying electro-oxidation in the presence of common
interfering molecules.

Results:
The developed sensor exhibited a linear response range of 2.0 μM to 34.0 μM, with a LOD
of 0.03 μM and a LOQ of 0.84 μM. Excellent recovery values were observed in human serum, urine,
and tablet dosage forms, demonstrating the sensor's applicability. The selectivity study confirmed the
sensor's ability to accurately quantify erlotinib in the presence of interfering substances.

Conclusion:
The research presents a novel and reliable technique for therapeutic drug monitoring of
erlotinib using a screen-printed electrode sensor. This method offers a quick, simple, and costeffective
approach for detecting ERL in actual samples, thereby facilitating improved dosage monitoring
in clinical settings.
Pengaruh Celebrity Endorser, Harga, Dan Event Marketing Terhadap Purchase Decision
Authors: Ishlah Benayya , Basuki Ananto 
Published: September 2024

The large number of users of Erigo products in Indonesia indicates that Erigo can attract the Indonesian market. Erigo is one of the largest clothing companies in Indonesia, which has attracted many consumers in Indonesia. Even so, consumers have different opinions on consumer purchasing decisions, especially on the aspect of customer satisfaction. While the research conducted can be categorized as explanatory research by applying quantitative research that explains causal relationships between variables through hypothesis testing. This study used a sample of 131 respondents with a minimum age of 18 years, domiciled in South Tangerang and know Erigo. The data analysis tools used were descriptive statistical analysis and multiple linear regression analysis with the SPSS version 26 program. Based on the results of testing the four hypotheses, it can be concluded that; (1) the celebrity endorser variable (X1), which has a significant influence on the Purchase Decision, (2) the Price variable (X2), which has a significant influence on the Purchase Decision, (3) the Event Marketing variable (X3) which has a significant influence on the Purchase Decision, and (4) the influence of the independent variables simultaneously on the Purchase Decision variable is acceptable.

Abstrak
Banyaknya jumlah pengguna produk Erigo di Indonesia menandakan bahwa Erigo dapat menarik pasar Indonesia. Erigo merupakan salah satu perusahaan pakaian terbesar di Indonesia, yang telah diminati banyak konsumen di Indonesia. Meskipun begitu, konsumen memiliki pendapat yang berbeda terhadap keputusan pembelian konsumen, terutama pada aspek kepuasan dari konsumen. Sedangkan penelitian yang dilakukan dapat dikategorikan pada penelitian explanatory research dengan menerapkan penelitian kuantitatif yang menjelaskan hubungan sebab akibat antar variabel melalui pengujian hipotesis. Penelitian ini menggunakan sampel sebanyak 131 responden dengan ketentuan berusia minimal 18 tahun, berdomisili di Tangerang Selatan dan mengetahui Erigo. Alat analisis data yang digunakan adalah analisis deskriptif statistik dan analisis regresi linear berganda dengan program SPSS versi 26. Berdasarkan hasil pengujian empat butir hipotesis, dapat disimpulkan bahwa; (1) variabel Celebrity endorser (X1), yang mempunyai pengaruh signifikan terhadap Purchase Decision, (2) variabel Harga (X2), yang mempunyai pengaruh signifikan terhadap Purchase Decision, (3) variabel Event Marketing (X3) yang mempunyai pengaruh signifikan terhadap Purchase Decision, dan (4) adanya pengaruh secara bersama-sama (simultan) variabel bebas terhadap variabel Purchase Decision dapat diterima.