bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcatheter closure of large atrial septal defects using 40 mm amplatzer septal occluder: Single group experience with short and intermediate term follow‐up
Authors: Dalvi Bharat , Sheth Kshitij , Jain Shreepal , Pinto Robin 
Published: November 2016

ObjectivesTo assess feasibility, safety, and efficacy of the use of 40 mm Amplatzer septal occluder (ASO 40) for the closure of large atrial septal defects (ASD).BackgroundThere is very little data available on closure of large ASDs with ASO 40.Materials and methodsCase records of patients who underwent ASD closure with ASO 40 between 2002 and 2014 were retrospectively analyzed. All patients had clinical, transthoracic, and transesophageal echocardiographic (TEE) evaluation prior to device closure. Postclosure follow‐up was done at 6 weeks, 6 months, and annually thereafter.Results87 patients underwent ASD closure using ASO 40 during the study period. Mean age and weight of the group was 32.4 ± 11.6 years and 59.5 ± 11.3 kg respectively. Mean ASD diameter on TEE was 32 ± 2.8 mm. The balloon stretched diameter (N = 40) was 37.8 ± 1.3 mm. The balloon assisted technique was used in 80/87 patients for device deployment. The procedure was successful in 84/87 patients. Follow‐up was available in 77 patients over a period of 44 ± 15.7 months. 3/77 patients had a small residual shunt. The severity of tricuspid regurgitation decreased in 40/77 patients. The pulmonary artery systolic pressure decreased from 49.7 ± 9.2 to 41.2 ± 6.2 mm Hg (N = 61; P < 0.05). The right ventricular diameter decreased from 35.1 ± 2.8 to 26.1 ± 3 mm (N = 77; P < 0.05).ConclusionASO 40 can be used safely and effectively with promising short and intermediate term results.© 2016 Wiley Periodicals, Inc.
Does direct stenting with drug‐eluting stents improve outcome? A meta‐analysis of 10,900 patients
Authors: Magalhaes Marco A. , Minha Sa'ar , Lhermusier Thibault , Pendyala Lakshmana , Escarcega Ricardo O. , Baker Nevin C. , Torguson Rebecca , Satler Lowell F. , Pichard Augusto , Waksman Ron 
Published: November 2016

ObjectivesThe aim of this study is to summarize the outcomes of patients undergoing direct stenting (DS) with drug‐eluting stents (DES) compared to those who underwent balloon predilatation.BackgroundDS has been associated with improved outcomes in the bare‐metal stent era. Although DS with DES implantation has been increasingly adopted in clinical practice, its safety and effectiveness remain controversial.MethodsThe search criteria identified 546 studies in the Medline/PubMed, Cochrane, and EMBASE databases from 2001 to July 2014. From these, seven studies totaling 10,900 patients were selected. Summarized estimates [odds ratio (OR) and 95% confidence intervals] were obtained using a random‐effects model. The primary outcomes were a composite of major adverse cardiac events (MACE), including all‐cause death, myocardial infarction (MI), and repeat revascularization. The secondary outcomes included a composite of death and MI and the rates of target lesion revascularization (TLR).ResultsOverall, 4101 (38%) and 6799 (62%) patients underwent DS with DES and balloon pre‐dilatation, respectively. DS with DES reduced the likelihood of MACE (OR: 0.81 [0.71–0.93]). Additionally, DS with DES was associated with reduced rates of death/MI (OR: 0.76 [0.62–0.92]), and TLR (OR: 0.66 [0.44–0.98]).ConclusionsDS with DES is safe and may be associated with better outcomes in selected patients. © 2016 Wiley Periodicals, Inc.
Effect of Post‐Treatment on Structure and Catalytic Activity of CuCo‐based Materials for Glycerol Oxidation
Authors: Dodekatos Georgios , Tüysüz Harun 
Published: November 2016

AbstractA series of CuCo‐based materials prepared by co‐precipitation with varied Co/Cu ratios and different post‐treatments were applied in the selective oxidation of glycerol in the aqueous phase under basic conditions. The influence of the post‐treatment on the structure of the materials and the catalytic performance was investigated in detail. As‐prepared materials without calcination and materials calcined under air with subsequent reduction under ethanol/N2 gas stream showed higher conversion of glycerol compared to samples solely calcined under air or to samples calcined under air with subsequent reduction under H2/Ar gas stream. The main products identified in the liquid phase were glyceric, glycolic, and formic acids. Systematic catalytic studies for differently prepared samples with varied Cu content and subsequent characterization of the materials by N2 physisorption, XRD, TEM, and EDX allowed for the identification of CoO(OH) in contact with CuO as the potentially active phases.
Reinventing Hsp90 Inhibitors: Blocking C‐Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors
Authors: Koay Yen Chin , Wahyudi Hendra , McAlpine Shelli R. 
Published: November 2016

AbstractHeat shock protein 90 (Hsp90) is a molecular chaperone (90 kDa) that functions as a dimer. This protein facilitates the folding, assembly, and stabilization of more than 400 proteins that are responsible for cancer development and progression. Inhibiting Hsp90’s function will shut down multiple cancer‐driven pathways simultaneously because oncogenic clients rely heavily on Hsp90, which makes this chaperone a promising anticancer target. Classical inhibitors that block the binding of adenine triphosphate (ATP) to the N‐terminus of Hsp90 are highly toxic to cells and trigger a resistance mechanism within cells. This resistance mechanism comprises a large increase in prosurvival proteins, namely, heat shock protein 70 (Hsp70), heat shock protein 27 (Hsp27), and heat shock factor 1 (HSF‐1). Molecules that modulate the C‐terminus of Hsp90 are effective at inducing cancer‐cell death without activating the resistance mechanism. Herein, we describe the design, synthesis, and biological binding affinity for a series of dimerized C‐terminal Hsp90 modulators. We show that dimers of these C‐terminal modulators synergistically inhibit Hsp90 relative to monomers.
A Synthetic Toolbox for the In Situ Formation of Functionalized Homo‐ and Heteropolysaccharide‐Based Hydrogel Libraries
Authors: Dibbert Nick , Krause Andreas , Rios‐Camacho Julio‐Cesar , Gruh Ina , Kirschning Andreas , Dräger Gerald 
Published: November 2016

AbstractA synthetic toolbox for the introduction of aldehydo and hydrazido groups into the polysaccharides hyaluronic acid, alginate, dextran, pullulan, glycogen, and carboxymethyl cellulose and their use for hydrogel formation is reported. Upon mixing differently functionalized polysaccharides derived from the same natural precursor, hydrazone cross‐linking takes place, which results in formation of a hydrogel composed of one type of polysaccharide backbone. Likewise, hydrogels based on two different polysaccharide strands can be formed after mixing the corresponding aldehydo‐ and hydrazido‐modified polysaccharides. A second line of these studies paves the way to introduce a biomedically relevant ligand, namely, the adhesion factor cyclic RGD pentapeptide, by using an orthogonal click reaction. This set of modified polysaccharides served to create a library of hydrogels that differ in the combination of polysaccharide strands and the degree of cross‐linking. The different hydrogels were evaluated with respect to their rheological properties, their ability to absorb water, and their cytotoxicity towards human fibroblast cell cultures. None of the hydrogels studied were cytotoxic, and, hence, they are in principal biocompatible for applications in tissue engineering.
Hydrogenated Bismuth Molybdate Nanoframe for Efficient Sunlight‐Driven Nitrogen Fixation from Air
Authors: Hao Yuchen , Dong Xiaoli , Zhai Shangru , Ma Hongchao , Wang Xiuying , Zhang Xiufang 
Published: November 2016

AbstractSunlight‐driven dinitrogen fixation can lead to a novel concept for the production of ammonia under mild conditions. However, the efficient artificial photosynthesis of ammonia from ordinary air (instead of high pure N2) has never been implemented. Here, we report for the first time the intrinsic catalytic activity of Bi2MoO6 catalyst for direct ammonia synthesis under light irradiation. The edge‐exposed coordinatively unsaturated Mo atoms in an Mo−O coordination polyhedron can act as activation centers to achieve the chemisorption, activation, and photoreduction of dinitrogen efficiently. Using that insight as a starting point, through rational structure and defect engineering, the optimized Bi2MoO6 sunlight‐driven nitrogen fixation system, which simultaneously possesses robust nitrogen activation ability, excellent light‐harvesting performance, and efficient charge transmission was successfully constructed. As a surprising achievement, this photocatalytic system demonstrated for the first time ultra‐efficient (1.3 mmol g−1 h−1) and stable sunlight‐driven nitrogen fixation from air in the absence of any organic scavengers.
Epicocconone–Hemicyanine Hybrids: Near Infrared Fluorophores for Protein Staining and Cell Imaging
Authors: Karuso Peter , Loa Kum Cheung Wendy , Peixoto Philippe A. , Boulangé Agathe , Franck Xavier 
Published: November 2016

AbstractThe development of new near infrared (NIR) dyes is crucial for diverse applications and especially bioimaging, as they absorb and emit light in the “therapeutic window“ (650–950 nm). We report here a new family of NIR fluorophores that has been obtained by hybridising hemicyanines with epicocconone. Emission wavelengths of these hybrid dyes is in the range 715–795 nm and is combined with large Stokes’ shifts (75–95 nm). The absorption and emission wavelength can be modulated according to the hemicyanine moiety and adding sulfonic acid moieties enhances water solubility. We demonstrate their application in the sensitive detection of proteins in gel electrophoresis and the staining of specific cellular organelles in confocal microscopy. These results are particularly encouraging and bring forward a new fluorescent skeleton for chemical biology.
Radical Reaction Control in the AdoMet Radical Enzyme CDG Synthase (QueE): Consolidate, Destabilize, Accelerate
Authors: Jäger Christof M. , Croft Anna K. 
Published: November 2016

AbstractControlling radical intermediates and thus catalysing and directing complex radical reactions is a central feature of S‐adensosylmethionine (SAM)‐dependent radical enzymes. We report ab initio and DFT calculations highlighting the specific influence of ion complexation, including Mg2+, identified as a key catalytic component on radical stability and reaction control in 7‐carboxy‐7‐deazaguanine synthase (QueE). Radical stabilisation energies (RSEs) of key intermediates and radical clock‐like model systems of the enzyme‐catalysed rearrangement of 6‐carboxytetrahydropterin (CPH4), reveals a directing role of Mg2+ in destabilising both the substrate‐derived radical and corresponding side reactions, with the effect that the experimentally‐observed rearrangement becomes dominant over possible alternatives. Importantly, this is achieved with minimal disruption of the thermodynamics of the substrate itself, affording a novel mechanism for an enzyme to both maintain binding potential and accelerate the rearrangement step. Other mono and divalent ions were probed with only dicationic species achieving the necessary radical conformation to facilitate the reaction.
Hydroxyapatite Nanowires@Metal–Organic Framework Core/Shell Nanofibers: Templated Synthesis, Peroxidase‐Like Activity, and Derived Flexible Recyclable Test Paper
Authors: Chen Fei‐Fei , Zhu Ying‐Jie , Xiong Zhi‐Chao , Sun Tuan‐Wei 
Published: November 2016

AbstractThe templated synthesis of hydroxyapatite (HAP) nanowires@metal–organic framework (MOF) core/shell nanofibers (named HAP@MIL‐100(Fe) nanofibers) is demonstrated. The ultralong hydroxyapatite nanowires are adopted as a hard template for the nucleation and growth of MIL‐100(Fe) (a typical MOF) through the layer‐by‐layer method. The Coulombic and chelation interactions between Ca2+ ions on the surface of the HAP nanowires and the COO− organic linkers of MIL‐100(Fe) play key roles in the formation process. The as‐prepared, water‐stable HAP@MIL‐100(Fe) nanofibers exhibit peroxidase‐like activity toward the oxidation of different peroxidase substrates in the presence of H2O2, accompanied by a clear color change of the solution. Furthermore, a flexible, recyclable HAP@MIL‐100(Fe) test paper is prepared successfully by using HAP@MIL‐100(Fe) nanofibers as building blocks. A simple, low‐cost, and sensitive colorimetric method for the detection of H2O2 and glucose is established based on the as‐prepared, flexible, recyclable HAP@MIL‐100(Fe) test paper. More importantly, the HAP@MIL‐100(Fe) test paper can be recovered easily for reuse by simply dipping in absolute ethanol for just 30 min, thus showing excellent recyclability. With its combination of advantages such as easy transportation, easy storage and use, rapid recyclability, light weight, and high flexibility, this HAP@MIL‐100(Fe) test paper is promising for wide applications in various fields.
Multicomponent Aqueous Synthesis of Iodo‐1,2,3‐triazoles: Single‐Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling
Authors: Li Lingjun , Ding Shengqiang , Yang Yanping , Zhu Anlian , Fan Xincui , Cui Mengchao , Chen Changpo , Zhang Guisheng 
Published: November 2016

AbstractIodo‐1,2,3‐triazoles are of considerable interest for chemical and biomedical applications. However, current synthetic methods for preparing iodo‐1,2,3‐triazoles cannot easily be applied to the direct modification of bioactive molecules in water. Through the combination of water‐compatible oxidative iodination and the copper‐catalyzed alkyne–azide cycloaddition reaction, a novel copper‐catalyzed aqueous multicomponent synthetic method for the preparation of 5‐iodo‐1,2,3‐triazoles has been developed. The method is highly effective and selective for substrates including biologically relevant compounds with nucleoside, sugar, and amino acid moieties. Based on this aqueous tandem reaction, a direct single‐step multicomponent dual modification of peptide is developed from readily available starting materials. Furthermore, the method could also be applied to concise and fast multicomponent radioactive 125I labeling from an aqueous solution of commercially available sodium 125iodide as a starting material.
Enantioselective Synthesis of N−H‐Free 1,5‐Benzothiazepines
Authors: Wang Guojin , Tang Yu , Zhang Yu , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: November 2016

AbstractAn enantioselective sulfa‐Michael‐cyclization reaction was developed for the synthesis of 1,5‐benzothiazepines with versatile pharmacological activities. The reaction between 2‐aminothiophenol and α,β‐unsaturated pyrazoleamides gave direct access to N−H‐free 1,5‐benzothiazepines in the presence of a chiral N,N′‐dioxide/Yb(OTf)3 complex. Excellent enantioselectivities (up to 96 % ee) and high yields (up to 99 %) were obtained for a broad range of substrates under mild reaction conditions. This method provided a facile approach to the antidepressant drug (R)‐(−)‐Thiazesim.
Effects of solvent on inclusion complexation of a chiral dipeptide toward racemic BINOL
Authors: Hu Xiaoyun , Yang Yuyuan , Shi Shuai , Shan Zixing 
Published: November 2016

AbstractThe effects of reaction solvent on inclusion complexation of a chiral dipeptide (3S,6S)‐1 derived from (S)‐proline toward racemic BINOL was investigated, discovering that the reaction solvent played a crucial role in determining the inclusion complexation behavior of dipeptide (3S,6S)‐1 toward rac‐BINOL. (3S,6S)‐1 did not show any chiroselective or achiroselective complexation toward rac‐BINOL in polar protic solvents such as methanol and ethanol, polar aprotic solvents including trichloromethane and THF, while in polar aprotic solvent ethyl acetate and apolar aprotic solvents benzene, (3S,6S)‐1 displayed achiroselective complexation toward rac‐BINOL. However, the resulting heterocomplex HC‐2 from benzene and HC‐3 from ethyl acetate have a different composition. Single crystal X‐ray diffraction analysis demonstrates that the two heterocomplexes are formed via different H‐bond interaction patterns, in which the reaction solvent has a dramatic effect. Furthermore, this work provides a relatively green method for quantitative enantiomeric enrichment of nonracemic BINOL, in which unacceptable and toxic benzene was replaced by ethyl acetate.
Trends in hospitalization for congestive heart failure, 1996–2009
Authors: Munir Muhammad Bilal , Sharbaugh Michael S. , Thoma Floyd W. , Nisar Muhammad Umer , Kamran Amir S. , Althouse Andrew D. , Saba Samir 
Published: November 2016

BackgroundAlthough heart failure (HF) is a common cause of hospital admissions, few data describe temporal trends in HF hospitalization. We present data on number of HF admissions, length of stay (LOS), and inpatient mortality in the United States, 1996–2009.HypothesisTo assess HF hospitalizations in a national sample of United States population.MethodsData were obtained from the National Hospital Discharge Survey (NHDS), a national probability sample survey of discharges conducted annually by the National Center for Health Statistics. Sampling weights are applied to raw NHDS data to produce national estimates. Hospitalizations with a primary diagnosis of HF were identified using ICD‐9‐CM codes. We excluded hospitalizations where HF was a secondary diagnosis. Weighted least squares regression was used to test for linear trends in HF hospitalizations.ResultsApproximately 15.5 million weighted primary HF hospitalizations were included. The number of total primary HF hospitalizations increased from 1 000 766 in 1996 to about 1 173 832 in 2009 (β = 7371 hospitalizations per year; 95% confidence interval (CI): 552 to 14 190, P = 0.036). Mean LOS per hospitalization decreased from 6.07 days in 1996 to about 5.26 days in 2009 (β = −0.059 days per year; 95% CI: −0.079 to −0.039, P < 0.001). Inpatient mortality rates declined from 4.92% in 1996 to 3.41% in 2009 (β = −0.17% per year; 95% CI: −0.23 to −0.10, P < 0.001).ConclusionsIn a nationally representative sample of HF hospitalizations, mean LOS and inpatient mortality rates declined over the past 2 decades. HF management cost is most likely to be reduced by decreasing the number of HF admissions.
What is the role of retroperitoneal exploration in optimally debulked stage IIIC epithelial ovarian cancer? An NRG Oncology/Gynecologic Oncology Group ancillary data study
Authors: Rungruang Bunja J. , Miller Austin , Krivak Thomas C. , Horowitz Neil S. , Rodriguez Noah , Hamilton Chad A. , Backes Floor J. , Carson Linda F. , Friedlander Michael , Mutch David G. , Goodheart Michael J. , Tewari Krishnansu S. , Wenham Robert M. , Bookman Michael A. , Maxwell G. Larry , Richard Scott D. 
Published: November 2016

BACKGROUNDThe purpose of this study was to determine the effect of retroperitoneal (RP) exploration on progression‐free survival (PFS) and overall survival (OS) in epithelial ovarian cancer (EOC) patients with stage IIIC disease who underwent optimal debulking surgery.METHODSData were collected from records of the Gynecologic Oncology Group 182 (GOG‐182) study of stage IIIC EOC patients cytoreduced to no gross residual disease (R0) or minimal gross residual (<1 cm) disease (MGRD) at primary surgery. Patients with stage IIIC disease by intraperitoneal (IP) tumor were included and divided into 3 groups: 1) > 2 cm IP tumor without lymph node involvement (IP/RP−), 2) > 2 cm IP tumor with lymph node involvement (IP/RP+), and 3) > 2 cm IP tumor with no RP exploration (IP/RP?). The effects of disease distribution and RP exploration on PFS and OS were assessed using Kaplan–Meier and proportional hazards methods.RESULTSThere were 1871 stage IIIC patients in GOG‐182 who underwent optimal primary debulking surgery. Of these, 689 (36.8%) underwent RP exploration with removal of lymph nodes from at least 1 para‐aortic site, and 1182 (63.2%) did not. There were 269 patients in the IP/RP− group, 420 patients in the IP/RP + group, and 1182 patients in the IP/RP? group. Improved PFS (18.5 vs 16.0 months; P < .0001) and OS (53.3 vs 42.8 months; P < .0001) were associated with RP exploration versus no exploration. Patients with MGRD had improved PFS (16.8 vs 15.1 months, P = 0.0108) and OS (44.9 vs 40.5 months, P = 0.0076) versus no exploration.CONCLUSIONSRP exploration at the time of primary surgery in patients with optimally debulked stage IIIC EOC is associated with a survival benefit. Cancer 2017;123:985–93. © 2016 American Cancer Society.
Bevacizumab combined with capecitabine and oxaliplatin in patients with advanced adenocarcinoma of the small bowel or ampulla of vater: A single‐center, open‐label, phase 2 study
Authors: Gulhati Pat , Raghav Kanwal , Shroff Rachna T. , Varadhachary Gauri R. , Kopetz Scott , Javle Milind , Qiao Wei , Wang Huamin , Morris Jeffrey , Wolff Robert A. , Overman Michael J. 
Published: November 2016

BACKGROUNDCapecitabine with oxaliplatin (CAPOX) has previously demonstrated clinical activity in patients with small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC). Herein, the authors conducted a phase 2 trial to evaluate the benefit of adding bevacizumab to CAPOX.METHODSIn this phase 2, single‐arm, single‐center, open‐label study, patients aged ≥18 years with untreated, advanced SBA or AAC were recruited. Patients received capecitabine at a dose of 750 mg/m2 orally twice daily on days 1 to 14, oxaliplatin at a dose of 130 mg/m2 intravenously on day 1, and bevacizumab at a dose of 7.5 mg/kg intravenously on day 1 of a 21‐day cycle. The primary endpoint was progression‐free survival (PFS) at 6 months. Secondary objectives included response rate, overall PFS, overall survival, and toxicity.RESULTSBetween August 2011 and November 2014, a total of 30 patients were enrolled into the study (male/female ratio of 13/17; median age of 63 years [range, 33‐78 years]; and 7 patients with an Eastern Cooperative Oncology Group performance status [ECOG PS] of 0, 20 patients with an ECOG PS of 1, and 3 patients with an ECOG PS of 2). Of the 30 patients, 23 (77%) had SBA (18 of duodenal origin and 5 of jejunal/ileal origin) and 7 patients (23%) had AAC (5 of pancreaticobiliary subtype, 1 of mixed subtype, and 1 of intestinal subtype). The most common grade 3 toxicities observed were fatigue and hypertension (7 patients each [23%]), neutropenia (6 patients [20%]), and diarrhea (3 patients [10%]) (toxicity was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events [version 4.0]). The probability of PFS at 6 months was 68% (95% confidence interval [95% CI], 52% to 88%). The response rate was 48.3%, with 1 complete response and 13 partial responses; 10 patients achieved stable disease. At a median follow‐up of 25.9 months, the median PFS was 8.7 months (95% CI, 4.9‐10.5 months) and the median overall survival was 12.9 months (95% CI, 9.2‐19.7 months).CONCLUSIONSThe results of the current study indicate that CAPOX with bevacizumab is an active and well‐tolerated regimen for patients with SBA and AAC. These findings support the need for further investigation into the clinical benefit of targeting angiogenesis in patients with SBA and AAC. Cancer 2017;123:1011–17. © 2016 American Cancer Society.