bluuebunny/crossref_metadata_2025_split huggingface dataset:
CAP Reform and Price Transmission in the Italian Pasta Chain
Authors: Cacchiarelli Luca , Lass Daniel , Sorrentino Alessandro 
Published: March 2016

ABSTRACTDuring the last several years, wheat‐pasta chains have been affected by Common Agricultural Policy (CAP) reforms in the durum wheat sector that have progressively reduced government intervention in the market. Specifically, the mid‐term reform, implemented in 2005, represented a deep change in the tools applied in the CAP, with a change from coupled income support to a single decoupled aid where farmers’ incomes are directly supported and are no longer linked to levels or types of production. We hypothesize that price transmission along the wheat‐pasta supply chain has been affected by CAP reform and other events through greater price volatility for durum wheat and market power exerted by some firms along the supply chain. For the present study, we are particularly interested in examining whether and how CAP reform has altered price transmission in the Italian wheat‐pasta chain, from farmer to retailer, including the wholesale stage. We employ the Kinnucan and Forker model, which provides a convenient instrument for analyzing the impact of policy intervention, and adapted its structure to the characteristics and the composition of the pasta supply chain by introducing an intermediate level (wholesale price), represented by semolina producers. The results suggest that pricing behavior has changed after CAP Reform introduction. [EconLit citations: Q110; Q130; L110].
In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica‐related pathology
Authors: Herwerth Marina , Kalluri Sudhakar Reddy , Srivastava Rajneesh , Kleele Tatjana , Kenet Selin , Illes Zsolt , Merkler Doron , Bennett Jeffrey L. , Misgeld Thomas , Hemmer Bernhard 
Published: March 2016

ObjectiveNeuromyelitis optica (NMO) is an autoimmune disease of the central nervous system, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover, the majority of NMO patients carry immunoglobulin G autoantibodies against aquaporin‐4 (AQP4), an astrocytic water channel. Antibodies against AQP4 can damage astrocytes by complement, but NMO histopathology also shows demyelination, and — importantly—axon injury, which may determine permanent deficits following NMO relapses. The dynamics of astrocyte injury in NMO and the mechanisms by which toxicity spreads to axons are not understood.MethodsHere, we establish in vivo imaging of the spinal cord, one of the main sites of NMO pathology, as a powerful tool to study the formation of experimental NMO‐related lesions caused by human AQP4 antibodies in mice.ResultsWe found that human AQP4 antibodies caused acute astrocyte depletion with initial oligodendrocyte survival. Within 2 hours of antibody application, we observed secondary axon injury in the form of progressive swellings. Astrocyte toxicity and axon damage were dependent on AQP4 antibody titer and complement, specifically C1q.InterpretationIn vivo imaging of the spinal cord reveals the swift development of NMO‐related acute axon injury after AQP4 antibody‐mediated astrocyte depletion. This approach will be useful in studying the mechanisms underlying the spread of NMO pathology beyond astrocytes, as well as in evaluating potential neuroprotective interventions. Ann Neurol 2016;79:794–805
β‐Ag3RuO4, a Ruthenate(V) Featuring Spin Tetramers on a Two‐Dimensional Trigonal Lattice
Authors: Prasad Beluvalli E. , Kazin Pavel , Komarek Alexander C. , Felser Claudia , Jansen Martin 
Published: March 2016

AbstractOpen‐shell solids exhibit a plethora of intriguing physical phenomena that arise from a complex interplay of charge, spin, orbital, and spin‐state degrees of freedom. Comprehending these phenomena is an indispensable prerequisite for developing improved functional materials. This type of understanding can be achieved, on the one hand, by experimental and theoretical investigations into known systems, or by synthesizing new solids displaying unprecedented structural and/or electronic features. β‐Ag3RuO4 may serve as such a model system because it possesses a remarkable anionic structure, consisting of tetrameric polyoxoanions (Ru4O16)12−, and is an embedded fragment of a 2D trigonal MO2 lattice. The notorious frustration of antiferromagnetic (AF) exchange couplings on such lattices is thus lifted, and instead strong AF occurs within the oligomeric anion, where only one exchange path remains frustrated among the relevant six. The strong magnetic anisotropy of the [Ru4O16]12− ion, and the effectively orbital nature of its net magnetic moment, implies that this anion may reveal the properties of a single‐molecule magnet if well‐diluted in a diamagnetic matrix.
Childhood cancer in children with congenital anomalies in Oklahoma, 1997 to 2009
Authors: Janitz Amanda E. , Neas Barbara R. , Campbell Janis E. , Pate Anne E. , Stoner Julie A. , Magzamen Sheryl L. , Peck Jennifer D. 
Published: March 2016

BackgroundData‐linkage studies have reported an association between congenital anomalies and childhood cancer. However, few studies have focused on the differences in the effect of congenital anomalies on cancer as a function of attained age. We aimed to examine associations between anomalies and childhood cancer as a function of attained age among children born in Oklahoma.MethodsData were obtained from the Oklahoma State Department of Health from 1997 to 2009 (n = 591,235). We linked Vital Statistics records for singleton deliveries to the Oklahoma Birth Defects Registry and the Oklahoma Central Cancer Registry using name and birth date. To assess the relation between anomalies and childhood cancer, we used Cox regression analysis allowing for a nonproportional hazards for anomalies as a function of age.ResultsThere were 23,368 (4.0%) children with anomalies and 531 (0.1%) children with cancer. When considering 3‐year age intervals, we detected an increased hazard of any childhood cancer in children with anomalies compared with those without anomalies before 1 year of age (hazard ratio, 14.1; 95% confidence interval, 8.3–23.7) and at 3 years of age (hazard ratio, 2.3; 95% confidence interval, 1.6–3.2). The increased hazard declined with increasing time since birth, with the effect diminished by 6 years of age.ConclusionOur results were consistent with previous studies indicating an increased rate of childhood cancer among children with anomalies at younger ages. Furthermore, our study added a methodological refinement of assessing the effect of anomalies as a function of attained age. Birth Defects Research (Part A) 106:633–642, 2016. © 2016 Wiley Periodicals, Inc.
High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressiveness
Authors: Long Elodie , Ilie Marius , Bence Coraline , Butori Catherine , Selva Eric , Lalvée Salomé , Bonnetaud Christelle , Poissonnet Gilles , Lacour Jean‐Philippe , Bahadoran Philippe , Brest Patrick , Gilson Eric , Ballotti Robert , Hofman Véronique , Hofman Paul 
Published: March 2016

AbstractCirculating tumors cells (CTCs) can be detected in the blood of metastatic melanoma patients (MMPs) both as isolated circulating tumor cells (iCTCs) and circulating tumor microemboli (CTMs), but their clinical significance remains unknown. The aim of this work was to evaluate the prognostic impact in metastatic cutaneous melanoma of CTMs and iCTCs identified by a cytomorphological approach using the isolation by size of tumor cell (ISET) method. We characterized the phenotype of CTCs using anti‐PS100, anti‐SOX10, anti‐CD10, and anti‐TRF2 antibodies. 128 MMPs and 37 control healthy individuals with benign nevi were included in this study. Results were compared to the follow‐up of patients. 109/128 (85%) MMPs showed CTCs, 44/128 (34%) with 2 to 6 CTMs and 65/128 (51%) with 4 to 9 iCTCs. PS100 expression was homogeneous in iCTCs and heterogeneous in CTMs. SOX10, CD10, and TRF2 were mainly expressed in CTMs. None of the control subjects demonstrated circulating malignant tumor cells. Overall survival was significantly decreased in patients with CTMs, independently of the therapeutic strategies. In conclusion, the presence of CTMs is an independent predictor of shorter survival from the time of diagnosis of MMPs.
Inhibition of HIV‐1 Reverse Transcriptase Dimerization by Small Molecules
Authors: Tintori Cristina , Corona Angela , Esposito Francesca , Brai Annalaura , Grandi Nicole , Ceresola Elisa Rita , Clementi Massimo , Canducci Filippo , Tramontano Enzo , Botta Maurizio 
Published: March 2016

AbstractBecause HIV‐1 reverse transcriptase is an enzyme whose catalytic activity depends on its heterodimeric structure, this system could be a target for inhibitors that perturb the interactions between the protein subunits, p51 and p66. We previously demonstrated that the small molecule MAS0 reduced the association of the two RT subunits and simultaneously inhibited both the polymerase and ribonuclease H activities. In this study, some analogues of MAS0 were rationally selected by docking studies and evaluated in vitro for their ability to disrupt dimeric assembly. Two inhibitors were identified with improved activity compared to MAS0. This study lays the basis for the rational design of more potent inhibitors of RT dimerization.
The china patient‐centered evaluative assessment of cardiac events (PEACE) prospective study of percutaneous coronary intervention: Study design
Authors: Du Xue , Pi Yi , Dreyer Rachel P. , Li Jing , Li Xi , Downing Nicholas S. , Li Li , Feng Fang , Zhan Lijuan , Zhang Haibo , Guan Wenchi , Xu Xiao , Li Shu‐Xia , Lin Zhenqiu , Masoudi Frederick A. , Spertus John A. , Krumholz Harlan M. , Jiang Lixin ,   for the China PEACE Collaborative Group
Published: March 2016

BackgroundThe number of percutaneous coronary interventions (PCI) in China has increased more than 20‐fold over the last decade. Consequently, there is a need for national‐level information to characterize PCI indications and long‐term patient outcomes, including health status, to understand and improve evolving practice patterns. Objectives: This nationwide prospective study of patients receiving PCI is to: (1) measure long‐term clinical outcomes (including death, acute myocardial infarction [AMI], and/or revascularization), patient‐reported outcomes (PROs), cardiovascular risk factor control and adherence to medications for secondary prevention; (2) determine patient‐ and hospital‐level factors associated with care process and outcomes; and (3) assess the appropriateness of PCI procedures. Methods: The China Patient‐centered Evaluative Assessment of Cardiac Events (PEACE) Prospective Study of PCI has enrolled 5,000 consecutive patients during 2012–2014 from 34 diverse hospitals across China undergoing PCI for any indication. We abstracted details of patient's medical history, treatments, and in‐hospital outcomes from medical charts, and conducted baseline, 1‐, 6‐, and 12‐month interviews to characterize patient demographics, risk factors, clinical presentation, healthcare utilization, and health status using validated PRO measures. The primary outcome, a composite measure of death, AMI and/or revascularization, as well as PROs, medication adherence and cardiovascular risk factor control, was assessed throughout the 12‐month follow‐up. Blood and urine samples were collected at baseline and 12 months and stored for future analyses. To validate reports of coronary anatomy, 2,000 angiograms are randomly selected and read by two independent core laboratories. Hospital characteristics regarding their facilities, processes and organizational characteristics are assessed by site surveys. Conclusion: China PEACE Prospective Study of PCI will be the first study to generate novel, high‐quality, comprehensive national data on patients’ socio‐demographic, clinical, treatment, and metabolic/genetic factors, and importantly, their long‐term outcomes following PCI, including health status. This will build the foundation for PCI performance improvement efforts in China. © 2016 The Authors. Catheterization and Cardiovascular Interventions. Published by Wiley Periodicals, Inc.
Efficacy and safety of transcatheter aortic valve replacement in intermediate surgical risk patients: A systematic review and meta‐analysis
Authors: Khan Abdur Rahman , Khan Sobia , Riaz Haris , Luni Faraz Khan , Simo Herman , Bin Abdulhak Aref , Bavishi Chirag , Flaherty Michael 
Published: March 2016

BackgroundThe efficacy of transcatheter aortic valve replacement (TAVR) in aortic stenosis patients at high surgical risk has been established. The data on patients with intermediate risk is not conclusive. We performed a meta‐analysis of studies which compared TAVR with surgical aortic valve replacement (SAVR) in patients at intermediate surgical risk.MethodsSeveral databases searched from inception to February 2015 yielded 7 eligible studies with 2,173 participants. The measured outcome of efficacy was all‐cause mortality. Data on safety included stroke, permanent pacemaker implantation (PPI), aortic regurgitation (AR), vascular access complications, and major bleeding. Outcomes were pooled and relative risk (RR) was calculated with the Mantel–Haenszel method.ResultsThere was no difference in either short‐term (RR, 1.02; 95% CI: 0.63–1.63; P = 0.94; I2 = 0%) or medium to long‐term all‐cause mortality (RR, 0.99; 95% CI: 0.81–1.21; P = 0.91; I2 = 0%). There was increased incidence of stroke (RR, 2.96; 95% CI: 0.87–10.09; P = 0.08; I2 = 0%), AR (RR, 3.59; 95% CI: 2.13–7.19; P < 0.00001; I2 = 2%), PPI (RR, 6.53; 95% CI: 1.91–22.32; P < 0.003; I2 = 0%) and vascular access complications (RR, 3.84; 95% CI: 0.65–22.76; P < 0.14; I2 = 48%) in patients with TAVR. There was a small, albeit increased risk of major or life threatening bleeding with SAVR as compared to TAVR (RR, 1.36; 95% CI: 1.04–1.80; P < 0.03; I2 = 0%).ConclusionsIn this meta‐analysis we found that TAVR may be an acceptable alternative to SAVR in patients with intermediate risk for surgery. However, we must await evidence from the current large randomized trials before widespread adoption of this procedure is undertaken. © 2016 Wiley Periodicals, Inc.
Acute kidney injury following peripheral angiography and endovascular therapy: A systematic review of the literature
Authors: Prasad Anand , Ortiz‐Lopez Carolina , Khan Aazib , Levin Daniel , Kaye David M. 
Published: March 2016

IntroductionRadiographic contrast administration is a major cause of acute kidney injury (AKI), worldwide. Currently, contrast induced acute kidney injury (CI‐AKI) is the third leading cause of hospital acquired renal failure in the United States. Over 50% of these cases are the result of contrast exposure during cardiac catheterization. The predictive risk factors for and clinical impact of AKI following coronary procedures have been extensively studied and documented in the literature. Similar data, however, are lacking for AKI following angiography or endovascular interventions for lower extremity peripheral artery disease (PAD).MethodsThe present review examined the published data available for AKI in patients undergoing peripheral procedures using MEDLINE searches. Specific data on number of peripheral cases, subject characteristics, hydration strategies, and AKI incidence rates was recorded.ResultsThe systematic review resulted in 50 potentially relevant studies and ultimately 15 studies were selected for detailed analysis that included AKI incidence data on patients undergoing peripheral angiography or interventions. The summated studies included 11,311 patients and 10,316 peripheral procedures. The median incidence of AKI in the studies was 10%. The retrieved publications demonstrated significant variations in patient risk factors, definitions of AKI, and specificity of description of endovascular therapies.ConclusionsThe incidence, risk factors, and outcomes related to AKI in the context of peripheral angiography or endovascular therapy remain poorly described in the literature and warrant further study in a prospective, systematic fashion. © 2016 Wiley Periodicals, Inc.
Zotarolimus compared with everolimus eluting stents‐angiographic and clinical results after recanalization of true coronary chronic total occlusions
Authors: Markovic Sinisa , Lützner Michael , Rottbauer Wolfgang , Wöhrle Jochen 
Published: March 2016

ObjectivesTo evaluate angiographic and clinical results of ZES compared with EES after recanalization of CTOs.BackgroundZES and EES showed similar clinical results in non‐CTO lesions. Whether ZES and EES are also comparable in true CTO lesions (TIMI 0 flow, duration of occlusion of more than 3 months) with a higher risk of restenosis has not been addressed so far.Methods125 patients with successful CTO recanalization via antegrade or retrograde approach were included. EES were implanted in 68 patients and ZES in 57 patients. Dual antiplatelet therapy was prescribed for 12 months. Follow‐up angiography was scheduled at 9 months and clinical follow‐up at 12 months. The primary angiographic outcome measure was in‐stent late lumen loss. Primary clinical outcome measures were target lesion revascularization rate (TLR) and major adverse cardiac events (MACE) as a composite of cardiac death, TLR and myocardial infarction not clearly attributable to a non‐target vessel.ResultsBaseline characteristics were similar in both groups. Mean stent length was 72.8 ± 33.0mm with EES and 70.8 ± 31.5 mm with ZES (P = 0.72). In‐stent late lumen loss was 0.50 ± 0.71 mm for EES compared with 0.59 ± 0.72 (P = 0.52) for ZES. There were similar rates for TLR (EES 10.3% versus ZES 10.5%, P = 0.97) and MACE (EES 10.3% versus ZES 12.3%). No definite or probable stent thrombosis occurred. Stent length but not type of stent was predictive for in‐stent late loss and TLR.ConclusionZES and EES showed similar angiographic and clinical outcomes for treatment of CTOs. © 2016 Wiley Periodicals, Inc.
γ‐AApeptides as a New Class of Peptidomimetics
Authors: Teng Peng , Shi Yan , Sang Peng , Cai Jianfeng 
Published: March 2016

AbstractSequence‐specific peptidomimetics are molecules that mimic the structure and function of peptides and proteins. With new backbones and molecular frameworks, peptidomimetics are of considerable interest in addressing challenges encountered in chemical biology and biomedical sciences. Based on the γ‐PNA backbone, a new class of peptidomimetics ‐ “γ‐AApeptides” were recently developed. Both linear and cyclic γ‐AApeptides can be synthesized with high efficiency. Compared with α‐peptides, γ‐AApeptides are resistant to enzymatic degradation, and amendable to diversification with a variety of chemical groups. Moreover, they could mimic primary and secondary structure, as well as the function of peptides, and show promise in biological applications, such as the development of new agents combating bacteria, cancer, and Alzheimer's disease. A few research outcomes of γ‐AApeptides are highlighted in this Concept article, and a future perspective is also proposed.
Pd(0)‐Catalyzed Dearomative Diarylation of Indoles
Authors: Petrone David A. , Kondo Masaru , Zeidan Nicolas , Lautens Mark 
Published: March 2016

AbstractWe have developed a protocol for a Pd(0)‐catalyzed dearomative syn 1,2‐diarylation of indoles using readily available boroxines (dehydrated boronic acids) as coupling partners. This reaction proceeds efficiently using PtBu3 as the ligand to divergently access to fused indolines while minimizing the extent of direct Suzuki coupling. The scope of the reaction is remarkably broad and all products are obtained as single diastereomers in moderate to excellent yields. We have also compiled data which parallels the steric and electronic properties of both substrate and boroxine with the propensity to undergo the desired dearomative process over direct Suzuki coupling.
Phosphoramidate‐Supported Cp*IrIIIAminoborane H2B=NR2Complexes: Synthesis, Structure, and Solution Dynamics
Authors: Drover Marcus W. , Bowes Eric G. , Schafer Laurel L. , Love Jennifer A. , Weller Andrew S. 
Published: March 2016

AbstractReaction of aminoboranes H2B=NR2(R=iPr or Cy) with the cationic Cp*IrIIIphosphoramidate complex [IrCp*{κ2‐N,O‐Xyl(N)P(O)(OEt)2}][BArF4] generates the aminoborane complexes [IrCp*(H){κ1‐N‐η2‐HB‐Xyl(N)P(OBHNR2)(OEt)2}][BArF4] (R=iPr or Cy) in which coordination of a P=O bond with boron weakens the B=N multiple bond. For these complexes, solution‐ and solid‐state, as well as DFT computational techniques, have been employed to substantiate B−N bond rotation of the coordinated aminoborane.
ChemInform Abstract: AENDERUNG DER KOORDINATIONSZAHL VON BOR BEI DER THERMISCHEN BEHANDLUNG VON ALUMOBOROSILICAT‐GLASFASERN
Authors: STEPANOV A. P. , HOVIKOV S. N. 
Published: March 2016

AbstractRöntgenographisch, durch Adsorptionsmessungen bei tiefer Temperatur und durch Aufnahme der 11B‐NMR werden die Umwandlungen in einer kommerziellen Glasfaser bei Erhitzung auf 100‐600°C untersucht.
ChemInform Abstract: DIE INTERMOLEKULARE WECHSELWIRKUNG DER ′NICHT EBENEN DEFORMATIONSSCHWINGUNG′ IN CARBONATEN
Authors: STERZEL W. , SCHNEE W.‐D. 
Published: March 2016

AbstractFür eine Reihe von Carbonaten (I)‐(III) mit Aragonitstruktur und Strukturen ähnlicher Anionennachbarschaft werden mit Hilfe von "C‐Isotopensubstitutionen die Kopplungskonstanten für die yg‐Schwingung der Carbonationen berechnet.
ChemInform Abstract: EINE ELEKTROOPTISCHE METHODE ZUR BESTIMMUNG VON REKOMBINATIONSRATE UND TERMVERTEILUNG AN HALBLEITEROBERFLAECHEN
Authors: GOBRECHT H. , DE HAAN A. , THULL R. 
Published: March 2016

AbstractAus der internen Reflexionsspektroskopie wurde eine einfache Meßmethode zur Untersuchung der Eigenschaften des oberflächennahen Bereiches von Halbleiterelektronen entwickelt.
ChemInform Abstract: PVT‐MESSUNGEN AN KONZENTRIERTER SALZSAEURE BIS 500 GRAD UND 1500 BAR
Authors: RAU HANS , KUTTY T. R. NARAYANAN 
Published: March 2016

AbstractAn konzentriertem (3 7%igem) HCl wurden PVT‐Messungen bis 500°C und 1 500 bar durchgeführt.
ChemInform Abstract: STABILE CARBOKATIONEN 133. MITT. BICYCLONONYL‐ UND METHYLBICYCLOOCTYL‐KATIONEN
Authors: OLAH GEORGE A. , LIANG GAO , WISEMAN JOHN R. , CHONG JOSHUA A. 
Published: March 2016

AbstractDer Mechanismus der Umlagerung z.B. des aus 1‐Chlor‐bicyclo[3.2.2]nonan in Fluorsulfonsäure‐Antimonpentafluorid‐SOzClF bei ‐90°C erzeugten 2‐Methylbicyclo[3.2.1 ]octy1‐(2)‐Kations bei ‐30°C in das Bicyclo[4.3.0]nonyl‐(1)‐Kation, das z.B. auch aus Bicyclo[4.3.0]nonan erzeugt wird, wird untersucht.
ChemInform Abstract: UNTERSUCHUNG DER ELIMINIERUNG ZUM ALLEN IN GEGENWART VON THIOLATIONEN IN N,N‐DIMETHYLFORMAMID
Authors: BALLABIO M. , BELTRAME P. L. , BELTRAME P. 
Published: March 2016

AbstractAnhand der Kinetik der Reaktion von 2‐Halogen‐1,1‐diphenyl‐propen (Halogen: C1, Br) mit Na‐toluol‐p‐thiolat in DMF zu 1,1‐Diphenyl‐2‐(p‐tolylmercapto)‐propen wird der Mechanismus untersucht.
ChemInform Abstract: MEISENHEIMER‐UMLAGERUNG VON METHOXYMETHYLPHENYLSULFOXID, BLDG. UND DISPROPORTIONIERUNG VON METHOXYMETHYLBENZOLSULFENAT
Authors: MARICICH TOM J. , HARRINGTON CLINTON K. 
Published: March 2016

AbstractDas durch Oxidation mit m‐Chlorperbenzoesäure aus dem entsprechenden Sulfid entstandene Sulfoxid (I) (90% Ausbeute) lagert sich in 2 Tagen in das Sulfenat (II) um.
ChemInform Abstract: PHOTOCHEMISCHE UNTERSUCHUNGEN 11. MITT. PHOTOSUBSTITUTION VON CHINOXALIN IN NEUTRALEM MEDIUM
Authors: CASTELLANO A. , CATTEAU J. P. , LABLACHE‐COMBIER A. , PLANCKAERT B. , ALLAN G. 
Published: March 2016

AbstractBei Bestrahlung in Diäthyläther geht das Chinoxalin (I) in einer Monophotonenreaktion über das intermediäre Radikal (II) in das Substitutionsprodukt (III) als Hauptprodukt über.
ChemInform Abstract: DIE KATALYSE VON UEBERGANGSMETALLDERIVATEN, DIE AUF POLYMEREN ORGANISCHEN TRAEGERN AUFGEBRACHT SIND
Authors: KOHLER N. , DAWANS F. 
Published: March 2016

AbstractDie möglichen Vorteile des im Titel genannten Typs von Katalysatoren gegen= über konventionellen heterogenen oder homogenen Katalysatoren werden diskutiert.