bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolutionary genetic analysis uncovers multiple species with distinct habitat preferences and antibiotic resistance phenotypes in theStenotrophomonas maltophiliacomplex
Authors: Ochoa-Sánchez Luz Edith , Vinuesa Pablo 
Published: May 2017

AbstractThe genusStenotrophomonas(Gammaproteobacteria) has a broad environmental distribution.S. maltophiliais its best known species because it is a globally emerging, multidrug-resistant (MDR), opportunistic pathogen. Members of this species are known to display high genetic, ecological and phenotypic diversity, forming the so-calledS. maltophiliacomplex (Smc). Heterogeneous resistance and virulence phenotypes have been reported for environmental Smc isolates of diverse ecological origin. We hypothesized that this heterogeneity could be in part due to the potential lumping of several cryptic species in the Smc. Here we used state-of-the-art phylogenetic and population genetics methods to test this hypothesis based on the multilocus dataset available for the genus at pubmlst.org. It was extended with sequences from complete and draft genome sequences to assemble a comprehensive set of reference sequences. This framework was used to analyze 108 environmental isolates obtained in this study from the sediment and water column of four rivers and streams in Central Mexico, affected by contrasting levels of anthropogenic pollution. The aim of the study was to identify species in this collection, defined as genetically cohesive sequence clusters, and to determine the extent of their genetic, ecological and phenotypic differentiation. The multispecies coalescent, coupled with Bayes factor analysis was used to delimit species borders, together with population genetic structure analyses, recombination and gene flow estimates between sequence clusters.These analyses consistently revealed that the Smc contains at least 5 significantly differentiated lineages:S. maltophiliaand Smc1 to Smc4. OnlyS. maltophiliawas found to be intrinsically MDR, all its members expressing metallo-β-lactamases (MBLs). The other Smc lineages were not MDR and did not express MBLs. We also obtained isolates related toS. acidaminiphila,S. humiandS. terrae. They were significantly more susceptible to antibiotics thanS. maltophilia. We demonstrate that the sympatric lineages recovered display significantly differentiated habitat preferences, antibiotic resistance profiles and beta-lactamase expression phenotypes, as shown by diverse multivariate analyses and robust univariate statistical tests. We discuss our data in light of current models of bacterial speciation, which fit these data well, stressing the implications of species delimitation in ecological, evolutionary and clinical research.
Clusternomics: Integrative Context-Dependent Clustering for Heterogeneous Datasets
Authors: Gabasova Evelina , Reid John , Wernisch Lorenz 
Published: May 2017

AbstractIntegrative clustering is used to identify groups of samples by jointly analysing multiple datasets describing the same set of biological samples, such as gene expression, copy number, methylation etc. Most existing algorithms for integrative clustering assume that there is a shared consistent set of clusters across all datasets, and most of the data samples follow this structure. However in practice, the structure across heterogeneous datasets can be more varied, with clusters being joined in some datasets and separated in others.In this paper, we present a probabilistic clustering method to identify groups across datasets that do not share the same cluster structure. The proposed algorithm, Clusternomics, identifies groups of samples that share their global behaviour across heterogeneous datasets. The algorithm models clusters on the level of individual datasets, while also extracting global structure that arises from the local cluster assignments. Clusters on both the local and the global level are modelled using a hierarchical Dirichlet mixture model to identify structure on both levels.We evaluated the model both on simulated and on real-world datasets. The simulated data exemplifies datasets with varying degrees of common structure. In such a setting Clusternomics outperforms existing algorithms for integrative and consensus clustering. In a real-world application, we used the algorithm for cancer subtyping, identifying subtypes of cancer from heterogeneous datasets. We applied the algorithm to TCGA breast cancer dataset, integrating gene expression, miRNA expression, DNA methylation and proteomics. The algorithm extracted clinically meaningful clusters with significantly different survival probabilities. We also evaluated the algorithm on lung and kidney cancer TCGA datasets with high dimensionality, again showing clinically significant results and scalability of the algorithm.Author SummaryIntegrative clustering is the task of identifying groups of samples by combining information from several datasets. An example of this task is cancer subtyping, where we cluster tumour samples based on several datasets, such as gene expression, proteomics and others. Most existing algorithms assume that all such datasets share a similar cluster structure, with samples outside these clusters treated as noise. The structure can, however, be much more heterogeneous: some meaningful clusters may appear only in some datasets.In the paper, we introduce the Clusternomics algorithm that identifies groups of samples across heterogeneous datasets. It models both cluster structure of individual datasets, and the global structure that appears as a combination of local structures. The algorithm uses probabilistic modelling to identify the groups and share information across the local and global levels. We evaluated the algorithm on both simulated and real world datasets, where the algorithm found clinically significant clusters with different survival outcomes.
Intestinal cell kinase regulates chondrocyte proliferation and maturation during skeletal development
Authors: Ding Mengmeng , Jin Li , Xie Lin , Park So Hyun , Tong Yixin , Wu Di , Fu Zheng , Li Xudong 
Published: May 2017

AbstractAn autosomal recessive loss-of-function mutation R272Q in humanICK(intestinal cell kinase) gene causes profound multiplex developmental defects in human ECO (endocrine-cerebro-osteodysplasia) syndrome. ECO patients exhibit a wide variety of skeletal abnormalities, yet the underlying cellular and molecular mechanisms by which ICK regulates skeletal development remain largely unknown. The goal of this study is to understand the structural and mechanistic basis underlying skeletal anomalies caused by ICK dysfunction.IckR272Q knock in transgenic mouse model not only recapitulated major ECO skeletal defects such as short limbs and polydactyly but also revealed a deformed spine with deficient intervertebral disc. Loss of ICK functions markedly reduces mineralization in the spinal column, ribs, and long bones.Ickmutants show a significant decrease in the number of proliferating chondrocytes and type X collagen-expressing hypertrophic chondrocytes in the spinal column and the growth plate of long bones. Our results demonstrate that ICK plays an important role in bone and intervertebral disc development by promoting chondrocyte proliferation and maturation, and thus provide novel mechanistic insights into the skeletal phenotypes of human ECO syndrome.
Reef fishes of praia do Tofo and praia da Barra, Inhambane, Mozambique
Authors: Fordyce Alexander J. 
Published: May 2017

AbstractThe coral reefs around Praia do Tofo and Praia da Barra, southern Mozambique, are known for their aggregations of marine megafauna but few studies have examined their reef fish biodiversity. This study assesses for the first time the ichthyofaunal diversity of the seas around Praia do Tofo and Praia da Barra. Methods involved underwater observations during recreational dives between February and September 2016, and the use of photographic records from 2015. A total of 353 species, representing 79 families, were recorded from 16 patch reefs in the region. The area shows comparable species diversity to others in the southwestern Indian Ocean, suggesting these reefs are in good condition. But high primary productivity driven by coastal upwelling may make fish diversity and trophic structure unreliable measures of the health of these reefs. Future studies investigating the sustainability of this ecosystem would benefit from utilising a wide range of reef health measures.
Discharging inpatients with intellectual disability from secure to community services: risk assessment and management considerations
Authors: Chester Verity , Brown Anthony Scott , Devapriam John , Axby Sharon , Hargreaves Claire , Shankar Rohit 
Published: May 2017

Purpose
There is increasing emphasis on caring for people with intellectual disabilities in the least restrictive, ideally community settings. Therefore, the purpose of this paper is to explore the risk factors considered by clinicians involved in discharging people from secure services.

Design/methodology/approach
The views of five senior clinicians were sought in semi structured interviews. Data were analysed thematically.

Findings
Themes related to risk assessment, risk management, and multidisciplinary and multiagency working. Illustrative quotes are used to evidence themes.

Practical implications
This study described the risk assessment and management factors considered during the discharge of patients from secure to community services, which are of direct relevance to multiple stakeholders post-Winterbourne.

Originality/value
Challenges when facilitating discharge were highlighted, such as ongoing risk management issues, or unexpected discharge from tribunals, and how these were addressed, via the development of extensive risk assessment and management processes, and interdisciplinary and interagency working.
The case for guided self-help for people with intellectual disabilities
Authors: Chaplin Eddie , Marshall-Tate Karina 
Published: May 2017

PurposeThe purpose of this paper is to examine guided self-help (GSH), and some of the barriers as to why it is not routinely available for people with intellectual disabilities (IDs).Design/methodology/approachThis paper offers an overview of GSH and the potential benefits of it as an intervention for people with ID with mild depression and/or anxiety.FindingsThe current literature reports the successful use and effectiveness of GSH in the general population. However, despite this there is little evidence that it is being used in practice for people with ID.Originality/valueThis paper offers an overview of GSH and advocates for its increasing use for people with ID to help bring about equality in mental healthcare.
Select the best supply chain by risk analysis for Indian industries environment using MCDM approaches
Authors: Chand Mahesh , Raj Tilak , Shankar Ravi , Agarwal Aashish 
Published: May 2017

PurposeRisk management in supply chain (SC) is not an easy task due to different uncertainty and intricacy. Management of risk is necessary for smooth operation of SC. The purpose of this paper is to demonstrate multi-criteria decision-making (MCDM) approaches to select the best SC which has minimum risks.Design/methodology/approachIn proposed methodologies different steps, i.e. goal, risk attributes, risk sub-attributes and alternatives are identified for the selection of best SC using analytical network process which is being followed by the Multi-Objective Optimization by Rational Analysis method.FindingsFindings of this paper are highly valuable for Indian manufacturing industries for risk management in SC. It helps the researchers and managers to deal with different types of uncertainty and risks associated with SC.Research limitations/implicationsThis research is limited only for risk management in SC. Other issues in SC can be analyzed and further extended by other MCDM approaches.Originality/valueThis paper identified the different risks in SC and a systematic way to find out the best SC which helps the researchers and managers in risk mitigation.
Corporate political activity and environmental sustainability disclosure
Authors: Kuo Lopin , Yu Hui-Cheng 
Published: May 2017

PurposeTaking on a corporate political activity (CPA) perspective, the purpose of this paper is to investigate how CPA affects environmental sustainability disclosure among firms in China and whether the disclosure level varies across ownership structures and environmental sensitivity statuses.Design/methodology/approachThe sample comprises 652 corporate social responsibility reports released by firms in China during 2008-2010. Data are coded through a content analysis procedure before being analyzed using regression analysis.FindingsThe authors find a significant and positive association between CPA and environmental sustainability disclosure. However, the effect of CPA on environmental sustainability disclosure is significantly negative among firms in the environmentally sensitive industries (ESIs) and privately owned enterprises (POEs). More specifically, a firm’s environmental disclosure level is lower when the proportion of board members with a significant status, such as party chief of the Communist Party, is higher among firms in ESIs and POEs. This implies that firms withguanxi(i.e. Chinese-specific CPA) are more likely to be free from trouble.Originality/valueThis empirical study offers important evidence on the fulfillment of environmental sustainability policies and the effectiveness of regulatory controls that China has used in the development toward a low-carbon economy.
The effect of global dynamic capabilities on internationalizing SMEs performance
Authors: Peng Yao-Ping , Lin Ku-Ho 
Published: May 2017

PurposeBased on a dynamic capability (DC) view, the purpose of this paper is to explore whether market orientation (MO) (external) and learning orientation (LO) (internal) facilitate internationalizing small- and medium-sized enterprises’ (ISMEs) global dynamic capabilities (GDCs) – i.e., their global marketing and product-design capabilities – and promote firm performance.Design/methodology/approachEmpirical data are randomly selected from Taiwanese ISMEs, yielding 206 valid responses. Informants’ (CEOs, vice presidents, senior managers) knowledge about and shouldering of firm responsibilities are explored.FindingsA significant increase in global marketing and product-design capabilities is found to affect firm performance. MO and LO positively influence GDCs, which increase firm performance. Furthermore, LO and MO support GDCs’ development.Research limitations/implicationsThe sample is reasonably diverse in terms of demographics including firm location, size, industry, and market type. Disaggregation results are generally robust regarding model parameters. However, future research should target different countries to assess result generalizability.Practical implicationsThe findings reveal two practical implications for managers. First, successful GDCs help firms spread the costs of designing products or components across many contexts and to offer appealing products to consumers worldwide. Second, it is important that managers foster development of MOs and LOs.Originality/valueThe study contributes to the literature in two ways. First, by conceptualizing GDCs of ISMEs, DC literature is expanded based on a global context. Second, the complexity of extending DC literature into ISMEs may arise from the fact that ISMEs, as separate and living entities, devise their own organizational culture, which significantly affects their GDC development.
Subordinates’ helping, voice, and supervisors’ evaluation of job performance
Authors: Choi Byoung Kwon , Moon Hyoung Koo 
Published: May 2017

PurposeIt is recognized that employees’ helping and voice behaviors are dimensions of organizational citizenship behavior used by supervisors to evaluate their job performance. However, existing empirical studies of these relationships have shown inconsistent findings. From the perspective of attributional theory, the purpose of this paper is to explain when subordinates’ helping and voice behaviors are more positively related to job performance by considering supervisor-attributed prosocial and impression management motives.Design/methodology/approachUsing a sample of 200 supervisors in South Korea, the authors tested the hypotheses with hierarchical multiple regression analyses.FindingsResults indicate that the positive effects of helping and voice behaviors on job performance were stronger when supervisors attributed such behaviors as driven less by impression management motives related to self-interest. However, contrary to the expectations, the positive influences of helping and voice behaviors on job performance were stronger when supervisors perceived low prosocial motives.Practical implicationsFindings suggest that supervisors need to avoid making the wrong attributions with regard to their subordinates’ helping and voice behaviors during the evaluation process. In addition, subordinates need to have clear motives and demonstrate consistent behavioral stances when engaging in such behaviors.Originality/valueUsing social information theory and attribution theory, this study contributes to explain when helping and voice behaviors improve evaluations of employees’ job performances by considering supervisor-attributed motives.
Work values underlying protean and boundaryless career orientations
Authors: Abessolo Marc , Hirschi Andreas , Rossier Jérôme 
Published: May 2017

PurposeThe purpose of this paper is to investigate the relation among work values and protean and boundaryless career orientations.Design/methodology/approachA sample of 238 employees aged 16 to 65 years from the French-speaking region of Switzerland completed two different work values scales as well as protean and boundaryless career attitudes scales. To assess the relationships among these constructs, correlations, multiple regression, and exploratory factorial analysis techniques were used.FindingsResults suggested that protean and boundaryless career orientations were significantly positively related to intrinsic, social, and status work values. A boundaryless-organizational mobility orientation was significantly negatively associated with extrinsic/material work values.Research limitations/implicationsResults have important implications for understanding which work values are typically endorsed by people with a protean or a boundaryless career orientation.Originality/valueThe present study contributes to the understanding of protean and boundaryless careers by clarifying the relationships among these career orientations and work values.
Mobile web application for students’ and lecturers’ portfolio gallery
Authors: Adinugroho Timothy Yudi , Heriyanni Eileen , Musthofa Tegar Aryo Sulthon 
Published: May 2017

Purpose
The purpose of this paper is to curate and promote students’ and lecturers’ works and creations, and to provide pleasing user experience for mobile device users when browsing the portfolio gallery information.

Design/methodology/approach
The design of the mobile web application using Rational Unified Process (RUP) methodology includes Unified Modeling Language (UML) diagrams. The evaluation is done in three steps: first step by comparing similar software, the second step by evaluate the interface using the eight golden rules and the last one by taking user questionnaire.

Findings
Evaluation of the application of Bina Nusantara University (BINUS) Store Mobile Web.

Originality/value
The authors report the development of BINUS Store Mobile web application by using Hypertext Preprocessor (PHP) with Laravel framework and evaluate it in Android and iOS environments.
The influence of supply chain quality management practices on quality performance: an empirical investigation
Authors: Soares Anabela , Soltani Ebrahim , Liao Ying-Ying 
Published: May 2017

PurposeThe extant literature highlights the notable lack of a consensus among operations and supply chain management scholars regarding the theoretical underpinnings and associated empirical evidence for the performance impact of supply chain quality management (SCQM) practices on quality. The purpose of this paper is to redress this imbalance in the literature through empirical examination of the relationship between SCQM practices and quality performance outcomes.Design/methodology/approachIn accordance with the research aim, a quantitative approach was adopted, and a multi-item scale Web-based survey was designed to collect primary data. A total number of 325 questionnaires were collected from a sample of UK-based manufacturing companies. Factor analysis, internal consistency and multivariate regressions were used to validate the multi-item scale and test the hypotheses.FindingsThe findings confirm the proposed hypotheses and reveal statistically significant results for the performance impact of SCQM practices on quality at an aggregate level. However, the results of the individual level analysis of SCQM practices appear to vary from practice to practice. Of various SCQM practices, customer focus with the highest beta value (i.e.ß= 0.303;t-value = 6.120;p= 0.000) was found to have the greatest impact on quality performance.Practical implicationsThe findings encourage managers to place high priority on both inter-firm and intra-firm relationships as prerequisites for achieving superior quality performance. The propositions and the results of the study provide managers with some guidelines about effective management of upstream, midstream and downstream supply chain networks and awareness of the potential synergies arising from the combined effects of SCQM practices that could bring about desired quality performance outcomes across the entire supply chain network.Originality/valueReal and sustainable quality performance often requires an equal focus on both intra- and inter-firm relationships among supply chain partners. Therefore, effective management of quality across the entire supply chain is deemed essential if a firm is to smoothly supply high-quality products and services to customers. But little research has been devoted to understanding conceptual underpinnings of SCQM as well as empirical support and validation for the conceptualisation and measurement of SCQM practices. Based on the insights gained from social network theory, this paper makes an attempt to address this gap and examine the impact of SCQM practices on quality performance.
Developing social skills
Authors: Kelly Alex 
Published: May 2017

Purpose
The purpose of this paper is to discuss the different features of social skills and outline a hierarchy of social skills model.

Design/methodology/approach
This paper draws on clinical work over 25 years and presents the results of research using a hierarchical approach to developing social skills.

Findings
Social skills interventions delivered according to a hierarchy of social skills (self-awareness and self-esteem; body language; conversational skills; friendship skills; assertiveness) are effective in improving social skills.

Practical implications
Effective assessment should determine which skills to start with. Intervention should involve the environment, peers and a variety of direct instructional approaches to maximise the potential for success and generalisation into everyday life.

Originality/value
This paper provides an overview of social skills and social competence, stresses the importance of good assessment to target the start point for intervention and emphasises the need to involve others to maximise success and generalisation.