bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-traumatic stress disorder among military personnel admitted at the Northwest Command Level Three Military Hospital, Bahir Dar, Ethiopia, 2022: an institution-based cross-sectional study
Authors: Tedla Assasahegn , Asnakew Sintayehu , Legas Getasew , Munie Birhanu Mengist , Tareke Minale , Beka Micheal 
Published: September 2024

BackgroundPost-traumatic stress disorder (PTSD) is one of the most common mental health problems that military personnel encounter. It could be lifelong and affect every aspect of military personnel, including their mental and physical health, family and social interactions, and their work. However, in Ethiopia, the magnitude and its associated factors have not been well investigated.ObjectiveThis study aimed to determine the prevalence of PTSD and its associated factors among military personnel, who were admitted at the Northwest Command Level Three Military Hospital, Bahir Dar, Northwest, Ethiopia, 2022.MethodsAn institution-based cross-sectional study was conducted from 21 June to 21 July 2022, at the Northwest Command Level Three Military Hospital. A computer-generated simple random sampling technique was used to select a total of 627 participants. The 17-item Military Version Checklist was utilized to measure PTSD. The Patient Health Questionnaire, Brief Resilience Coping, and Critical War Zone Experience scale were utilized to measure depression, resilience, and combat exposure, respectively. Descriptive, bivariate, and multivariate binary logistic regressions with odds ratios and a 95% confidence interval were used. The level of significance of the association was determined at a p-value &lt; 0.05.ResultsA total of 612 respondents participated, with a response rate of 97.6%. The prevalence of PTSD in this study was 21.9% (95% CI: 18.6, 25.2). In multivariable regression, female sex [adjusted odds ratio (AOR) = 2.3, 95% CI; 1.3, 3.87], combat personnel (AOR = 2.75, 95% CI; 1.44, 6.36), handling dead bodies (AOR = 2.5, 95% CI,1.24, 5.02), having 4–5 deployments (AOR = 2.94, 95% CI, 1.63, 5.32), having ≥6 deployments (AOR = 3.4, 95% CI, 1.95, 6.17), low resilience coping (AOR = 2.02, 95% CI; 1.16, 3.53), poor social support (AOR = 2.46, 95% CI, 1.39, 4.35), very high combat exposures (AOR = 4.8, 95% CI, 2.03, 11.93), and depression (AOR = 2.8, 95% CI, 1.68, 4.67) were significantly associated with PTSD.ConclusionPTSD is markedly prevalent among the Ethiopian military population, with key risk factors identified as being female, poor social support, low resilience coping skills, handling dead bodies, multiple deployments (four or more), high combat experiences, and depression. Healthcare professionals must prioritize the early diagnosis and intervention of PTSD in vulnerable groups of military personnel.
Correlating plasma protein profiles with symptomatology and treatment response in acute phase and early remission of major depressive disorder
Authors: Křenek Pavel , Bartečková Eliška , Makarová Markéta , Pompa Tomáš , Fialová Kučerová Jana , Kučera Jan , Damborská Alena , Hořínková Jana , Bienertová-Vašků Julie 
Published: September 2024

ObjectivesThis study aimed to explore the relationship between plasma proteome and the clinical features of Major Depressive Disorder (MDD) during treatment of acute episode.MethodsIn this longitudinal observational study, 26 patients hospitalized for moderate to severe MDD were analyzed. The study utilized Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS) alongside clinical metrics, including symptomatology derived from the Montgomery-Åsberg Depression Rating Scale (MADRS). Plasma protein analysis was conducted at the onset of acute depression and 6 weeks into treatment. Analytical methods comprised of Linear Models for Microarray Data (LIMMA), Weighted Correlation Network Analysis (WGCNA), Generalized Linear Models, Random Forests, and The Database for Annotation, Visualization and Integrated Discovery (DAVID).ResultsFive distinct plasma protein modules were identified, correlating with specific biological processes, and uniquely associated with symptom presentation, the disorder’s trajectory, and treatment response. A module rich in proteins related to adaptive immunity was correlated with the manifestation of somatic syndrome, treatment response, and inversely associated with achieving remission. A module associated with cell adhesion was linked to affective symptoms and avolition, and played a role in the initial episodes and treatment response. Another module, characterized by proteins involved in blood coagulation and lipid transport, exhibited negative correlations with a variety of MDD symptoms and was predominantly associated with the manifestation of psychotic symptoms.ConclusionThis research points to a complex interplay between the plasma proteome and MDD’s clinical presentation, suggesting that somatic, affective, and psychotic symptoms may represent distinct endophenotypic manifestations of MDD. These insights hold potential for advancing targeted therapeutic strategies and diagnostic tools.LimitationsThe study’s limited sample size and its naturalistic design, encompassing diverse treatment modalities, present methodological constraints. Furthermore, the analysis focused on peripheral blood proteins, with potential implications for interpretability.
Evidence map of traditional Chinese exercises
Authors: Yu Yan , Wu Tongtong , Wu Murou , Liu Shaonan , Chen Xueyin , Wu Jinpeng , Guo Xinfeng , Yang Lihong 
Published: September 2024

ObjectiveThis study aimed to assess and visually depict the clinical evidence landscape of traditional Chinese exercises and identify any research gaps and future research needs.MethodsWe comprehensively searched seven Chinese and English databases to identify randomized controlled trials (RCTs) and systematic reviews (SRs) evaluating the effects of traditional Chinese exercises from their inception until May 2023. The quality of evidence was assessed via the GRADE approach, and the research topics, intervention effects, and strength of evidence were graphically displayed.ResultsThis evidence map includes 2,017 studies, comprising 1,822 RCTs and 195 SRs. These studies were conducted globally in various countries. Among the traditional Chinese exercises, Tai Chi and Baduanjin have received the most research attention, with a growing number of publications. When traditional Chinese exercises were compared with the control groups, 88.2% of the included SRs reported significantly positive effects, 4.1% reported unclear effects, and 7.7% reported no significant differences. The findings suggested that traditional Chinese exercises could benefit patients with osteoarthritis, osteoporosis, hypertension, coronary heart disease, diabetes, chronic obstructive pulmonary disease, stroke, Parkinson’s disease, anxiety, and depression. However, the overall quality of the evidence was suboptimal, with 11.3% rated as moderate, 45.6% as low, and 43.1% as critically low.ConclusionThis evidence map visually represents valuable information on traditional Chinese exercises. While most studies have reported significant benefits, the overall quality of evidence is low.
Career adaptability and correlating factors among secondary vocational nursing students in China
Authors: Xiang Yuhe , Li Lin , Yang Qin , Fang YiQian , Xu Wenbin , Ding Xing , Yang Qian 
Published: September 2024

BackgroundCareer adaptability significantly affects college students’ career happiness in the future, and it is essential to make a detailed evaluation of its correlation for making a targeted intervention plan. However, the applicability of occupational adaptability to secondary vocational nursing students is still an unexplored field in academic research.ObjectiveThis study aimed to investigate the current situation of career adaptability and its influencing factors on secondary vocational nursing students in medical schools.MethodsA total of 1,414 secondary vocational nursing students from three secondary colleges and universities in Southwest China from July 2022 to September 2022 were selected for the survey. A questionnaire was used to assess secondary vocational nursing students’ sociodemographic, Career Adaptability, Psychological Control Sources, and the Meaning in Life. Statistical analyses were performed using Pearson’s correlation analysis, t-test, analysis of variance and multiple.ResultsSecondary vocational nursing students scored (51.03 ± 9.64) for the meaning in life, (81.46 ± 25.39) for psychological control sources, and (94.12 ± 15.55) for career adaptability. Career resilience was significantly and positively correlated with the opportunity and internal control factors of psychological control sources (r = 0.091, −0.488, p &lt; 0.01); and career adaptability was significantly and positively correlated with the sense of seeking meaning and possessing meaning factors of sense of meaning in life (r = 0.725, 0.734, p &lt; 0.01); Multiple linear regression analysis revealed that academic performance, mother’s educational level, search for meaning, sense of meaningfulness, opportunities, and internal control entered the regression equation (p &lt; 0.05), explaining 64% of the total variance.ConclusionThe overall career adaptability of secondary vocational nursing students is at a moderately high level, with significant individual differences closely correlated with locus of control, meaning in life, and career adaptability. Nursing educators can provide targeted intervention measures based on influencing factors to promote the development of secondary vocational nursing students’ career adaptability, enabling them to better adapt to future clinical work.
Awareness of HPV and HPV vaccine among college students in China
Authors: Li Manman , Zhang Fengzhi , Shi Yun , Shi Kaige , Li Xiaoxue , Bai Hua 
Published: September 2024

BackgroundCervical cancer is the fourth most common cancer among women, HPV vaccine can reduce the incidence of cervical cancer by approximately 70%. Sexual behavior is a direct risk factor for HPV infection, and sexually active college students, therefore, receive attention for HPV vaccination. This study aimed to investigate the awareness of HPV and its vaccine among college students in Zhengzhou, and to explore the factors influencing their awareness of HPV vaccine, to understand college students’ willingness to receive the vaccine. The findings of this study will lay a foundation for cervical cancer prevention.MethodsUsing a multistage random sampling method, 650 college students from four universities in Zhengzhou were selected. A self-administered questionnaire on the awareness of HPV and its vaccine, and willingness to receive HPV vaccination was carried out. Logistic regression was used to analyze the factors influencing students’ awareness of the HPV vaccine.Results58.0% of college students had heard of HPV, and 72.8% of college students had heard of HPV vaccine. Logistic regression showed that gender, major, grade, mean monthly consumption level, sexual history, and mother cervical cancer screening participation significantly influenced the awareness of HPV vaccine (p &lt; 0.05). Only 27(4.2%) college students had received the HPV vaccine. 63.2% of college students expressed their willingness to get vaccinated.ConclusionThe awareness of HPV and its vaccine among college students in Zhengzhou needs improvement. Although the vaccination rate is low, most college students are willing to be vaccinated. Diverse health education programs should be conducted for different groups to improve awareness of cervical cancer prevention and promote vaccination.
Effects of COVID-19 nursing home restrictions on people with dementia involved in a Supportive Care programme
Authors: Paccagnella Omar , Miele Francesco , Guzzon Angelica , Neresini Federico , Rebba Vincenzo , Rigon Michela , Boniolo Giovanni 
Published: September 2024

BackgroundSupportive Care is a person-centred approach encompassing non-pharmacological interventions targeted towards persons with dementia to contain the effects of their behavioural disorders, improving their quality of life.AimsTo investigate the effects of lockdown restrictions during the first wave of COVID-19 pandemic on behavioural symptoms of patients involved in a Supportive Care programme in an Italian nursing home.MethodsAnalysis is based on Neuropsychiatric Inventory (NPI) scores and related symptoms data collected before (October/November 2019) and after (July 2020) the introduction of COVID-19 restrictions on a non-random sample of 75 patients living in two units of the facility: 38 involved in a Supportive Care programme and 37 receiving standard care (Control). Group performances were compared over time according to univariate statistics and Latent Class Analysis (LCA).ResultsNPI scores and number of reported symptoms in NPI evaluations increased over time among Supportive Care patients with dementia and decreased in the Control group. Differences are statistically significant. LCA resulted in 3-classes and 5-classes specifications in the two time-occasions.DiscussionSupportive Care patients showed a worsening in behavioural and psychological symptoms after the first pandemic wave, as opposed to the elderly not involved in the programme. LCA showed that patients in the two groups differed according to the combinations of NPI symptoms.ConclusionsThe discontinuation of a Supportive Care programme due to COVID-19 restrictions had strong negative effects on nursing home persons with dementia involved in the programme: Supportive Care interventions are important in controlling the psycho-behavioural symptoms associated with dementia.
Indigenous interpretation in parks and protected areas on Turtle Island: a scoping review
Authors: Lemelin Raynald Harvey , Hurst Chris E. , Grimwood Bryan S. R. 
Published: September 2024

IntroductionThe interpretation of national, provincial, territorial, and state parks and heritage sites is a powerful social force that can foster or thwart respectful relationships between Indigenous and non-Indigenous peoples.MethodsBy conducting a scoping review of relevant literature, this study aims to initiate conversations about how Indigenous interpretation is conceptualized and practiced in relation to national, provincial, territorial, and state parks and heritage sites on Turtle Island (i.e., North America).ResultsFindings indicate that while Indigenous interpretation is rarely explicitly defined, several themes are consistently used to illustrate what Indigenous interpretation entails or should entail. Themes include: (i) responsibility and respect, (ii) relationships, (iii) place-based cultural identity and empowerment, (iv) contested stories and histories, and (v) storytelling.DiscussionWhile these thematic dimensions do not represent a definitive definition of Indigenous interpretation, they do suggest potential features that may enhance understandings and applications of Indigenous interpretation in parks, protected areas, and heritage sites on Turtle Island. They also reaffirm the importance of interpretive encounters as a social force encouraging relationships across cultures.
Overview of human health effects related to glyphosate exposure
Authors: Galli Flavia Silvia , Mollari Marta , Tassinari Valentina , Alimonti Cristian , Ubaldi Alessandro , Cuva Camilla , Marcoccia Daniele 
Published: September 2024

Glyphosate is a chemical compound derived from glycine, marketed as a broad-spectrum herbicide, and represents one of the most widely used pesticides in the world. For a long time, it was assumed that glyphosate was harmless, either due to its selective enzymatic acting method on plants, and because commercial formulations were believed to contain only inert chemicals. Glyphosate is widely spread in the environment, the general population is daily exposed to it via different routes, including the consumption of both plant, and non-plant based foods. Glyphosate has been detected in high amounts in workers’ urine, but has been detected likewise in bodily fluids, such as blood and maternal milk, and also in 60%–80% of general population, including children. Considering its massive presence, daily exposure to glyphosate could be considered a health risk for humans. Indeed, in 2015, the IARC (International Agency for Research on Cancer) classified glyphosate and its derivatives in Group 2A, as probable human carcinogens. In 2022, nevertheless, EFSA (European Food Safety Authority) stated that the available data did not provide sufficient evidence to prove the mutagenic/carcinogenic effects of glyphosate. Therefore, the European Commission (EC) decided to renew the approval of glyphosate for another 10 years. The purpose of this review is to examine the scientific literature, focusing on potential risks to human health arising from exposure to glyphosate, its metabolites and its commercial products (e.g., Roundup®), with particular regard to its mutagenic and carcinogenic potential and its effects as endocrine disrupter (ED) especially in the human reproductive system.
The Effect of Fascial Closure With Triclosan-Coated Sutures on the Incidence of Abdominal Wall Dehiscence: An Individual Participant Data Meta-Analysis
Authors: Timmer Allard S. , Wolfhagen Niels , Pianka Frank , Knebel Phillip , Justinger Christoph , Stravodimos Christos , Ichida Kosuke , Rikiyama Toshiki , Baracs József , Vereczkei András , Gianotti Luca , Sandini Marta , Ruiz-Tovar Jaime , Marc-Hernández Artur , Nakamura Toru , Dijkgraaf Marcel G. W. , Boermeester Marja A. , de Jonge Stijn W. 
Published: September 2024

IntroductionWound closure with triclosan-coated sutures (TCS) appears to reduce the risk of surgical site infection (SSI). Because there is a strong association between postoperative SSI and the development of acute abdominal wall dehiscence (AWD) after laparotomy, we hypothesized that the use of TCS for wound closure after laparotomy may also reduce the risk of AWD.MethodsThe MEDLINE, Embase, and CENTRAL databases were searched from their inception to 01 November 2022. Randomized trials that compared the use of TCS with identical but uncoated sutures for fascial closure were eligible if they could provide individual participant data (IPD) on AWD. From these trials, we only included in the analysis those subjects who underwent open abdominal surgery. The primary outcome was the incidence of AWD within 30 days postoperatively, requiring emergency reoperation. The certainty of evidence was assessed using the GRADE methodology (PROSPERO: CRD42019121173.ResultsWe identified twelve eligible trials. Eight studies shared IPD. The incidence of AWD within 30 days after surgery was 27/1,565 (1.7%) in the TCS group vs. 40/1,430 (2.8%) in the control group (Relative Risk: 0.70 [95% confidence interval (CI) 0.44–1.11, I2 = 0%, τ2 = 0.00]). The certainty of evidence was moderate after downgrading for imprecision. The incidence of incisional SSI was 163/1,576 (10.3%) vs. 198/1,439 (13.8%), RR 0.80 (95% CI 0.67–0.97).ConclusionWe found no conclusive evidence to support the use of triclosan-coated sutures for the prevention of acute abdominal wall dehiscence after laparotomy. In these selected studies, a significant reduction in incisional SSI was observed.
Forecasting the CBOE VIX and SKEW Indices Using Heterogeneous Autoregressive Models
Authors: Guidolin Massimo , Panzeri Giulia F. 
Published: September 2024

We analyze the predictability of daily data on the CBOE VIX and SKEW indices, used to capture the average level of risk-neutral risk and downside risk, respectively, as implied by S&P 500 index options. In particular, we use forecast models from the Heterogeneous Autoregressive (HAR) class to test whether and how lagged values of the VIX and of the SKEW may increase the forecasting power of HAR for the SKEW and the VIX. We find that a simple HAR is very hard to beat in out-of-sample experiments aimed at forecasting the VIX. In the case of the SKEW, the benchmarks (the random walk and an AR(1)) are clearly outperformed by HAR models at all the forecast horizons considered and there is evidence that special definitions of the SKEW index based on put options data only yield superior forecasts at all horizons.
Chloroplast Genome Variation and Phylogenetic Relationships of Autochthonous Varieties of Vitis vinifera from the Don Valley
Authors: Sharko F. S. , Petrova K. O. , Patrushev M. V. , Fedosov D. Y. , Toshchakov S. V. 
Published: September 2024

The autochthonous grape varieties of the Don Valley, situated in southern Russia, constitute a distinctive element of regional cultural heritage. These varieties have been adapted over centuries to the region’s specific local climatic and soil conditions. For the most part, these varieties are not imported from other countries. They are closely related to varieties found in Crimea and the North Caucasus. In this study, we obtained the first complete, unfragmented sequences of the chloroplast genomes of eight autochthonous varieties from the Don Valley and one from Crimea. We also performed a comparative analysis of their genomic features. The size of Vitis vinifera chloroplast genome sequences varied from 160,925 to 160,991 bp, depending on the cultivar, with a uniform GC ratio of 37.38%. Each genome consists of four subregions: a single copy region (LSC) ranging from 89,158 to 89,336 bp, a small single copy region (SSC) ranging from 19,070 to 19,073 bp, and a pair of inverted repeat regions (IRa and IRb) in the range of 26,292 to 26,353 bp. The chloroplast genomes of the studied V. vinifera varieties contained 130 genes, including 85 protein-coding genes, 8 rRNA genes, and 37 tRNA genes. The sequence divergence analysis has enabled the identification of four highly variable regions, which may be utilized as potential markers for phylogenetic analysis. The analysis revealed the presence of 58 to 61 SSRs and multiple long repeated sequences in the chloroplast genomes of these varieties. The phylogenetic analyses of the sequences obtained and complete chloroplast genomes available from public databases indicated that the majority of autochthonous V. vinifera varieties do not have a direct origin from any European variety.
Photosynthesis, Chlorophyll Fluorescence, and Hormone Regulation in Tomato Exposed to Mechanical Wounding
Authors: Yan Hui , Fu Kai , Li Jiajia , Li Mingyong , Li Shaofan , Dai Zhiguang , Jin Xin 
Published: September 2024

To understand the physiological responses of seedlings to mechanical wounding, we analyzed photosynthesis, chlorophyll fluorescence, and endogenous hormones in tomato (Solanum lycopersicum L.) subjected to varying levels of mechanical pressure. The results showed that, at 4 h after wounding, excess excitation energy was dissipated as thermal energy through the reduction in the photosystem II (PSII) opening degree and the increase in non-photochemical quenching. Photodamage was avoided, and stomatal closure was the most prominent factor in photosynthesis inhibition. However, 12 h after wounding, the photoprotective mechanism was insufficient to mitigate the excess excitation energy caused by the wound, leading to photochemical damage to physiological processes. Meanwhile, the non-stomatal factor became the most prominent limiting factor for photosynthesis at 80 N pressure. At 12 and 36 h after wounding, the concentrations of abscisic acid (ABA), methyl jasmonate (MeJA), indole-3-acetic acid (IAA), zeatin riboside (ZR), and gibberellic acid (GA3) in the stems showed a trend towards being increased, which promoted wound healing. However, after mechanical wounding, the ratio of stress- to growth-promoting hormones first increased and then decreased. This pattern can enhance stress resistance and promote cell division, respectively. Comprehensive analysis showed that the fluorescence parameter, photochemical quenching coefficient (Qp_Lss), was the most suitable indicator for evaluating mechanical wounding conditions.