bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capecitabine, 5-fluorouracil and S-1 based regimens for previously untreated advanced oesophagogastric cancer: A network meta-analysis
Authors: ter Veer Emil , Ngai Lok Lam , Valkenhoef Gert van , Mohammad Nadia Haj , Anderegg Maarten C. J. , van Oijen Martijn G. H. , van Laarhoven Hanneke W. M. 
Published: July 2017

AbstractAs evidence is inconsistent and based on either isolated Asian or Western studies, we conducted a network meta-analysis (NMA) to examine efficacy and safety of 5-FU (5-fluorouracil), capecitabine and S-1-based first-line treatment of advanced esophagogastric cancer in Asian and Western patients. Medline, EMBASE, CENTRAL and conferences ASCO and ESMO were searched up to January 2016 for randomized-controlled-trials comparing 5-FU, capecitabine or S-1-based regimens with equal chemotherapy backbones. Direct and indirect data for overall survival (OS) and progression-free-survival (PFS) were combined on the Hazard Ratio (HR)-scale using random-effects NMA and calculated as combined HRs and 95%credible intervals (95%CrI). Grade 1-2 and grade 3-4 adverse events were compared with pair-wise meta-analysis. Fifteen studies were identified including capecitabine (n = 945), 5-FU (n = 2,132) or S-1 (n = 1,636). No differences were found in respectively OS and PFS for capecitabine-based versus 5-FU-based regimens (HR = 0.89, 95%CrI = 0.76–1.04 and HR = 0.98, 95%CrI = 0.75–1.32), S-1-based versus 5-FU-based regimens (HR = 0.92, 95%CrI = 0.82–1.04 and HR = 0.88, 95%CrI = 0.70–1.11) and S-1-based versus capecitabine-based regimens (HR = 1.03, 95%CrI = 0.87–1.22 and HR = 0.89, 95%CrI = 0.65–1.20). Effects were similar in Asian and Western subgroups. Toxicity profiles were different but a lower frequency of relevant adverse events was observed with S-1 In conclusion, as efficacy was similar, choosing fluoropyrimidines should be based on their individual toxicity profiles.
A novel single-crystal & single-pass source for polarisation- and colour-entangled photon pairs
Authors: Laudenbach Fabian , Kalista Sebastian , Hentschel Michael , Walther Philip , Hübel Hannes 
Published: July 2017

AbstractWe demonstrate a new generation mechanism for polarisation- and colour-entangled photon pairs. In our approach we tailor the phase-matching of a periodically poled KTP crystal such that two downconversion processes take place simultaneously. Relying on this effect, our source emits entangled bipartite photon states, emerging intrinsically from a single, unidirectionally pumped crystal with uniform poling period. Its property of being maximally compact and luminous at the same time makes our source unique compared to existing photon-entanglement sources and is therefore of high practical significance in quantum information experiments.
SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer
Authors: Wu Dong-ming , Liu Teng , Deng Shi-hua , Han Rong , Xu Ying 
Published: July 2017

AbstractThe zinc transporter SLC39A4 influences epithelial cell morphology and migration in various cancers; however, its role in regulating cell invasion and chemotherapeutic resistance in human lung cancer is not yet clear. Here, integrated analysis of gene expression in non-small cell lung cancer revealed that SLC39A4 expression is significantly correlated with increased tumour size and regional lymph node spread, as well as shorter overall survival (OS) and disease-free survival (DFS). SLC39A4 silencing by lentivirus-mediated shRNA blocked human lung cancer cell epithelial-mesenchymal transition and metastasis in vitro and in vivo, respectively. Moreover, SLC39A4 knockdown enhanced cancer cell sensitivity to cisplatin-induced death by inhibiting stemness in lung cancer cells. Collectively, these data suggest that SLC39A4 may be a novel therapeutic target and predictive marker of tumour metastasis in non-small cell lung cancer.
The emerging role of zinc transporters in cellular homeostasis and cancer
Authors: Bafaro Elizabeth , Liu Yuting , Xu Yan , Dempski Robert E 
Published: July 2017

AbstractZinc is an essential micronutrient that plays a role in the structural or enzymatic functions of many cellular proteins. Cellular zinc homeostasis involves the opposing action of two families of metal transporters: the ZnT (SLC30) family that functions to reduce cytoplasmic zinc concentrations and the ZIP (SLC39) family that functions to increase cytoplasmic zinc concentrations. Fluctuations in intracellular zinc levels mediated by these transporter families affect signaling pathways involved in normal cell development, growth, differentiation and death. Consequently, changes in zinc transporter localization and function resulting in zinc dyshomeostasis have pathophysiological effects. Zinc dyshomeostasis has been implicated in the progression of cancer. Here we review recent progress toward understanding the structural basis for zinc transport by ZnT and ZIP family proteins, as well as highlight the roles of zinc as a signaling molecule in physiological conditions and in various cancers. As zinc is emerging as an important signaling molecule in the development and progression of cancer, the ZnT and ZIP transporters that regulate cellular zinc homeostasis are promising candidates for targeted cancer therapy.
Fully integrated high‐efficiency high step‐down ratio DC–DC buck converter with predictive over‐current protection scheme
Authors: Wang Langyuan , Zhao Menglian , Wu Xiaobo , Gong Xiaohan , Yang Liuqing 
Published: July 2017

A high‐efficiency fully integrated 36 V–3 A stepping down DC–DC converter with high step‐down ratio and predictive over‐current protection scheme is introduced. To achieve high‐voltage conversion ratio, emulated current mode and dedicated current sensing circuits were involved. A novel predictive over‐current scheme is proposed to overcome inherent lack of emulated current‐mode control and provide fast response to over‐current events. In addition, due to N‐type field effect transistor (NFET) was adopted to improve efficiency, a floating rail regulator is presented to generate bootstrapped voltage for driver stage. The proposed converter was simulated and fabricated in 0.18 μm bipolar‐complementary metal–oxide–semiconductor (MOS)‐double‐diffused MOS process. Experimental results show the features work well, and with 35 ns minimum on‐time, this converter can convert up to 36 V input voltage to 1.8 V at 1 MHz switching frequency with single stage and compact solution. Measured peak efficiency is 89.5% and over 80% efficiency for 3 A output current is realised as well.
Simultaneous fault detection algorithm for grid‐connected photovoltaic plants
Authors: Dhimish Mahmoud , Holmes Violeta , Mehrdadi Bruce , Dales Mark 
Published: July 2017

In this work, the authors present a new algorithm for detecting faults in grid‐connected photovoltaic (GCPV) plant. There are few instances of statistical tools being deployed in the analysis of photovoltaic (PV) measured data. The main focus of this study is, therefore, to outline a PV fault detection algorithm that can diagnose faults on the DC side of the examined GCPV system based on the t‐test statistical analysis method. For a given set of operational conditions, solar irradiance and module temperature, a number of attributes such as voltage and power ratio of the PV strings are measured using virtual instrumentation (VI) LabVIEW software. The results obtained indicate that the fault detection algorithm can detect accurately different types of faults such as, faulty PV module, faulty PV String, faulty Bypass diode and faulty maximum power point tracking unit. The proposed PV fault detection algorithm has been validated using 1.98 kWp PV plant installed at the University of Huddersfield, UK.
Cardiac Involvement in Sarcoidosis: Evolving Concepts in Diagnosis and Treatment
Authors: Sayah David , Bradfield Jason , Moriarty John , Belperio John , Lynch Joseph 
Published: July 2017

AbstractClinically evident sarcoidosis involving the heart has been noted in at least 2 to 7% of patients with sarcoidosis, but occult involvement is much higher (> 20%). Cardiac sarcoidosis is often not recognized antemortem, as sudden death may be the presenting feature. Cardiac involvement may occur at any point during the course of sarcoidosis and may occur in the absence of pulmonary or systemic involvement. Sarcoidosis can involve any part of the heart, with protean manifestations. Prognosis of cardiac sarcoidosis is related to the extent and site(s) of involvement. Most deaths due to cardiac sarcoidosis are due to arrhythmias or conduction defects, but granulomatous infiltration of the myocardium may be lethal. The definitive diagnosis of isolated cardiac sarcoidosis is difficult. The yield of endomyocardial biopsies is low; treatment of cardiac sarcoidosis is often warranted even in the absence of histologic proof. Radionuclide scans are integral to the diagnosis. Currently, 18F-fluorodeoxyglucose–positron emission tomography/computed tomography and gadolinium-enhanced magnetic resonance imaging scans are the key imaging modalities to diagnose cardiac sarcoidosis. The prognosis of cardiac sarcoidosis is variable, but mortality rates of untreated cardiac sarcoidosis are high. Although randomized therapeutic trials have not been done, corticosteroids (alone or combined with additional immunosuppressive medications) remain the mainstay of treatment. Because of the potential for sudden cardiac death, implantable cardioverter defibrillators should be placed in any patient with cardiac sarcoidosis and serious ventricular arrhythmias or heart block, and should be considered for cardiomyopathy. Cardiac transplantation is a viable option for patients with end-stage cardiac sarcoidosis refractory to medical therapy.
Quality of Life in Sarcoidosis
Authors: Judson Marc 
Published: July 2017

AbstractHealth-related quality of life (HRQL) is an important aspect of patient evaluation. HRQL is particularly important in sarcoidosis, where treatment decisions are often based on HRQL impairment. HRQL assessment in sarcoidosis must take into account not only the direct effects of the disease but also the disease's psychosocial and emotional impact as well as the potential toxicity of therapy. Patient-reported outcomes (PROs) have been used to assess HRQL in sarcoidosis cohorts. Recent HRQL PROs have been developed that are sarcoidosis-specific and have adequate resolution to be used for monitoring individual patients potentially. In this article, the approach to HRQL assessment in sarcoidosis is discussed. This article focuses on the general approach to HRQL assessment, specific sarcoidosis issues concerning HRQL assessment, the construction of HRQL PROs, and their application in sarcoidosis. Several HRQL issues in sarcoidosis will be specifically highlighted, including parasarcoidosis syndromes, sarcoidosis-induced fatigue, and the impact of corticosteroid therapy.
Primary Management of Large Pancreatic Pseudoaneurysm by Ultrasound-Guided Percutaneous Thrombin Injection after Failure of Transarterial Pseudoaneurysm Embolization
Authors: Garg Pawan , Khera Pushpinder , Rajagopal Rengarajan , Mehta Neeraj , Tarafdar Swarnava 
Published: July 2017

AbstractPancreatic pseudoaneurysm is a rare but life-threatening complication secondary to pancreatitis, surgery, trauma, or infection. Early treatment is advocated due to high risk of rupture and bleeding. Surgical treatment has traditionally been the first line but is associated with high morbidity. Transarterial embolization or exclusion is the treatment of choice; however, in cases with failure of endovascular treatment, percutaneous thrombin injection can be used successfully. We present a case of a large pancreatic pseudoaneurysm managed successfully with percutaneous ultrasound-guided thrombin injection after failure of transarterial management.
The Clinical and Technical Effectiveness of Endovascular Embolization in Patients with Nonvariceal Gastrointestinal Bleeding
Authors: Elmi Azadeh , Walker T. , Ganguli Suvranu , Kalva Sanjeeva 
Published: July 2017

Background and Aim Endovascular embolization is a well-established option in the management of acute gastrointestinal bleeding (GIB) after failed therapeutic endoscopy; however, questions remain concerning the outcomes and the various predictors of clinical and technical success of this therapy. The authors aimed to assess the effectiveness of endovascular embolization in patients with nonvariceal GIB.
Method Clinical records of 88 patients (mean age: 67.8 years) who underwent endovascular embolization for GIB were reviewed. Patient demographics, history, angiographic findings, treatment, and outcomes were recorded. The technical success of embolization, and the 24-hour and 30-day rebleeding and mortality rates were calculated. Multivariate analysis was performed to assess the factors associated with 24-hour and 30-day rebleeding.
Results Angiography demonstrated signs of bleeding in 63 (71.6%) patients and all underwent selective embolization of the abnormal artery. Empiric embolization was performed in 25 patients. Embolization was performed with coils (n = 45), Gelfoam (n = 12), microparticles (n = 14), glue (n = 2), or a combination of these (n = 15). The technical success rate was 96.6%. The 24-hour and 30-day rebleeding occurred in 13 (14.7%) and 16 (18.2%) patients, respectively. The 24-hour and 30-day mortality rates were 9.1 and 11.3%, respectively. Ischemic complications following embolization were seen in three patients, of which two required surgery. Based on the multivariate analysis, the need for continued transfusion after embolization and prior GIB were independent variables associated with 24-hour and 30-day rebleeding, respectively.
Conclusions Endovascular embolization has a high technical and clinical success in patients presenting with nonvariceal GIB.
A Novel Technique of Posterolateral Suturing in Thoracoscopic Diaphragmatic Hernia Repair
Authors: Boo Yoon , Rohleder Stephan , Muensterer Oliver 
Published: July 2017

Background Closure of the posterolateral defect in some cases of congenital diaphragmatic hernia (CDH) can be difficult. Percutaneous transcostal suturing is often helpful to create a complete, watertight closure of the diaphragm. A challenge with the technique is passing the needle out the same tract that it entered so that no skin is caught when the knots are laid down into the subcutaneous tissue. This report describes a novel technique using a Tuohy needle to percutaneously suture the posterolateral defect during thoracoscopic repair of CDH.
Case We report a case of a 6-week-old infant who presented with a CDH and ipsilateral intrathoracic kidney that was repaired using thoracoscopic approach. The posterolateral part of the defect was repaired by percutaneous transcostal suturing and extracorporeal knot tying. To assure correct placement of the sutures and knots, a Tuohy needle was used to guide the suture around the rib and out through the same subcutaneous tract. The total operative time was 145 minutes and there were no perioperative complications. The patient was followed up for 3 months, during which there was no recurrence.
Conclusion Our percutaneous Tuohy technique for closure of the posterolateral part of CDH enables a secure, rapid, and tensionless repair.
Auricular Composite Grafting in Functional Rhinoplasty
Authors: Toriumi Dean , Rao Neela 
Published: July 2017

AbstractSurgical correction of defects of the internal nasal valve, ala, vestibule, and sill is widely regarded as a challenge due to concerns of poor outcomes of facial aesthetics and nasal function. Auricular composite grafting is a reliable method of reconstruction of deformities of the nasal vestibule and sill. A classification system of types of defects may help surgeons in understanding the indications for composite grafting. Furthermore, we have developed surgical techniques that enhance survival of composite grafts of larger size. Composite grafting is an effective technique to repair a wide range of defects of the internal nasal valve, nasal sill/ala, and vestibule with excellent functional and aesthetic results.
Geometric Modeling of the Nasal Valve
Authors: Victor Wasnard , Sclafani Matthew , Sclafani Anthony 
Published: July 2017

AbstractWe have used a simple geometric model to examine forces affecting the nasal valve after dorsal reduction and spreader graft placement. The study was designed on the geometric modeling of the internal nasal valve (INV). Published measurements of the leptorrhine nose were used to construct a geometric model of the INV. The changes in the cross-sectional area (CSA) occurring after reduction rhinoplasty were calculated algebraically, as was the effect of these changes on the tendency of the lateral wall of the INV to collapse. The effect of spreader grafting on the CSA was determined, and the total change in CSA of the INV in various scenarios was determined and compared with the reported normal CSA. Relative to published norms, the gain in CSA from spreader grafting can be significant if thick grafts are used. When the lateral wall of the INV is conceptualized as a cantilevered beam fixed medially, the reduction of length reduction of the lateral segment of the INV can significantly reduce the tendency for the inward collapse of the lateral wall. The reduction in CSA of the INV associated with dorsal nasal reduction can be ameliorated through the placement of spreader grafts. Moreover, the reduction in length of the INV sidewall also limits inward collapse, assuming it is firmly reattached to the dorsal septum. An enhanced appreciation of the physical properties of the INV anticipated through a simplified geometric analysis will be invaluable to the rhinological surgeon interested in enhancing nasal function.
Pancreatic Kaposiform Hemangioendothelioma Not Responding to Sirolimus
Authors: Triana Paloma , Dore Mariela , Nuñez Vanesa , Jimenez Javier , Miguel Miriam , Díaz Mercedes , Ricardo Joan , Andres Ane , Lopez Santamaria Manuel , Lopez-Gutierrez Juan 
Published: July 2017

Background Kaposiform hemangioendothelioma (KHE) is a vascular tumor frequently associated with Kasabach–Merritt phenomenon (KMP), characterized by severe thrombocytopenia and consumptive coagulopathy. Visceral involvement in KHE is rare. In our recent experience, sirolimus has shown to be an effective treatment in cutaneous KHE, becoming indeed the treatment of choice in KMP. We report a case of pancreatic KHE associated with KMP and refractory to sirolimus.
Case Report A 4-month-old infant is referred for obstructive jaundice (10 mg/dL conjugated bilirubin) secondary to vascular pancreatic tumor. Magnetic resonance (MR) and immunohistochemistry were compatible with KHE, but the tumor was considered unresectable. We initiated sirolimus (0.8 mg/m2/12 h) to treat KMP, and interventional radiology was performed for percutaneous biliary diversion. This procedure prompted KMP (platelets: 51,000/µL). Sirolimus treatment for 7 days showed no effect; therefore, we started our VAT protocol (vincristine/aspirine/ticlopidin) with great response after 10 days (platelets: 3,70,000/µL). Three months later, percutaneous biliary diversion was replaced by a biliary stent. The tumor disappeared leaving fibrosis and dilatation of biliary tract needing hepaticojejunostomy 6 months later.
Discussion It is difficult to establish protocols for an unusual presentation of a tumor with different targets. This is a reason collaborative multicenter studies should be performed. Management of obstructive jaundice secondary to a tumor that usually regresses in 10 years is an added challenge; therefore, the management should be led by a multidisciplinary team.Sirolimus treatment in cutaneous KHE has been described as successful in the literature, as well as in our own experience; however, it failed in our first patient with visceral KHE. We need to investigate the different response to pharmacological agents in tumors with similar histopathology, but with visceral involvement.
Prevalence and Distribution of Diabetes Mellitus in a Maximum Care Hospital: Urgent Need for HbA1c-Screening
Authors: Kufeldt Johannes , Kovarova Marketa , Adolph Michael , Staiger Harald , Bamberg Michael , Häring Hans-Ulrich , Fritsche Andreas , Peter Andreas 
Published: July 2017

Abstract
Objective Diabetes mellitus affects almost one in 10 individuals in Germany. So far, little is known about the diabetes prevalence in maximum care hospitals. We assessed the diabetes prevalence, proportion of undiagnosed cases, the effectiveness of diabetes screening in a university hospital, the consequences for hospital stay and acquired complications.
Research Design and Methods Over a 4 week period we determined HbA1c from 3 733 adult patients which were hospitalized at the university hospital of Tuebingen and had an available blood sample. Diabetes diagnosis was defined as HbA1c≥6.5% and/or previously documented diabetes diagnosis, prediabetes was defined as HbA1c≥5.7% and <6.5% without history of previous diabetes.
Results 23.68% of the patients had prediabetes and 22.15% had diabetes with a high variation between the specialised departments (range 5–43%). The rate of unknown diabetes was 3.7%, the number needed to screen was 17 in patients older than 50 years. Patients with diabetes had a prolonged hospital stay compared to the mean length of stay for their diagnosis related group (diabetes: 1.47±0.24 days; no diabetes: −0.18±0.13 days, p=0.0133). The prevalence of hospital acquired complications was higher in diabetic patients (diabetes: 197 of 630; no diabetes: 447 of 2 459, p<0.0001).
Conclusions Every fourth patient in the university hospital had diabetes and every second had either prediabetes or diabetes. It is also worthwhile to screen for unknown diabetes in patients over the age of 50. The high prevalence and negative consequences of diabetes require screening and intensified specialized diabetes treatment in hospitals.
Post-polypectomy bleeding in the English National Health Service Bowel Cancer Screening Programme
Authors: Derbyshire Edmund , Hungin Pali , Nickerson Claire , Rutter Matthew 
Published: July 2017

Abstract
Background and study aims Colonoscopic polypectomy reduces colorectal cancer incidence, but is associated with complications including post-polypectomy bleeding (PPB). PPB ranges in severity from minor to life-threatening, making interpretation and comparison difficult. No previous studies have examined PPB rate according to a standardized severity grading system. We aimed to determine the PPB rate stratified by severity grading, explore factors that contribute to PPB severity grading, and describe PPB management.
Methods Data relating to PPB were prospectively collected from all colonoscopies performed in one region of the English NHS Bowel Cancer Screening Programme (BCSP) from 06/12/2010 to 15/07/2014. PPB was defined and stratified into major, intermediate, and minor according to BCSP standardized definitions based on the American Society for Gastrointestinal Endoscopy adverse events lexicon.
Results A total of 15 285 colonoscopies (23 766 polypectomies) were analyzed. The PPB rate per colonoscopy was 0.44 % (95 % confidence interval [CI] 0.34 – 0.54) and the rate per polypectomy was 0.29 % (95 %CI 0.20 – 0.38); 2.9 % of PPBs were major and 42.6 % were intermediate. Repeat endoscopy occurred in 27.9 % and was the most common reason for bleeding being categorized as of intermediate severity, although therapy was applied in only 36.8 % of these cases. A therapeutic intervention was significantly more common in patients with PPB who had either a hemoglobin drop ≥ 2 g/dL and/or a blood transfusion (P = 0.04, relative risk 3.47, 95 %CI 1.05 – 11.52).
Conclusions This study specifically examined colonoscopic PPB rate, stratified using standardized criteria. The rates of PPB were low, with the majority of PPB being of minor severity. Current stratification of PPB severity combines measures of bleed severity with interventions. Using only hemoglobin drop ≥ 2 g/dL and/or blood transfusion as markers of PPB severity may simplify stratification, and allow a better assessment of the necessity and impact of an intervention.