bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: A case of primary pericardial mesothelioma treated with multimodal combined therapy
Authors: Gong Jinlan , Wu Xiaofeng , Wang Jiehua 
Published: October 2024

BackgroundPrimary pericardial mesothelioma (PMPM) is a rare, aggressive, and lethal form of cancer. Due to its rarity, low incidence and poor prognosis, PMPM has no accepted standard-of-care treatment options with management and outcomes often extrapolated from diffuse pleural mesothelioma. Disease-specific studies are needed to better define PMPM. We report a case of PMPM highlighting the potential role for multimodal combined therapy.Case reportThe patient is a 62 years old female who had nonspecific syndromes and inconclusive image findings in May 2023. Then monthly follow-up echocardiography was performed. Two months later, cardiac ultrasound showed pericardial fluid. Pericardiocentesis with pericardial drain was performed. The fluid was bloody, cultivations for tuberculosis were negative and cytological analysis of the fluid showed no malignant cells. Positron emission tomography-computed tomography revealed that the lesion was localized at the anterior and left part of the mediastinum without distant metastasis. Followed up a pericardiectomy was operated. The diagnosis of PMPM is determined by pathological and immunohistochemical evaluation of tissue specimens. Postoperative patient experienced chest pain, right shoulder and upper limb swelling and pain. Pain management and anticoagulant therapy were administered. The patient underwent multimodal therapy consisting of surgical resection, six cycles of chemotherapy (carboplatin plus pemetrexed) in combination with pembrolizumab, and sequential adjuvant intensity-modulated radiation therapy, totaling 50 Gy in 25 fractions, as the first-line treatment, resulting in complete relief of symptoms and satisfactory outcomes with no complications. Presently, the tumor is under local control, with no signs of distant metastasis, and maintenance immunotherapy is scheduled. Continued observation is necessary for monitoring subsequent disease progression.ConclusionPMPM represents a distinct disease with no universally accepted treatment options. The case suggests that multimodal treatment may improve outcomes in selected patients with PMPM.
The association between circulating saturated fatty acids and thyroid function: results from the NHANES 2011−2012
Authors: Zhao Wei , Peng Xinnan , Liu Yazhuo , Li Shen , Li Xinyu , Gao Zhengnan , Han Cheng , Zhu Zizhao 
Published: October 2024

BackgroundExcessive saturated fatty acids (SFAs) are known to be detrimental to human health. Although the majority of research and dietary guidelines have focused on the intake of SFAs, there has been limited attention to the relationship between circulating SFA levels and hormonal regulation, such as that of thyroid hormones.MethodsTo explore potential associations, we conducted an investigation with 579 participants from the National Health and Nutrition Examination Survey (NHANES) 2011–2012. Subgroup analyses and multivariable linear regression models were used to estimate the relationships between eleven distinct SFA concentrations and various thyroid parameters.ResultsFor 579 adults, subgroup analysis of thyroid stimulating hormone (TSH) revealed significant differences in nine specific SFAs and the total SFA levels (all p &lt; 0.05). Furthermore, multivariable linear regression analysis identified positive correlations between certain SFAs and various parameters, including TSH, total triiodothyronine (TT3), free triiodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb), thyroglobulin (Tg), the ratio of FT3 to free thyroxine (FT4) (FT3/FT4), and the thyrotroph T4 resistance index (TT4RI). Conversely, negative correlations were observed between certain SFAs and total thyroxine (TT4), FT4, the ratio of FT3/TT3, and the thyroid feedback quantile-based index (TFQI) (all p &lt; 0.05).ConclusionThese findings collectively suggest associations between SFAs and thyroid parameters, highlighting the need for future studies to elucidate the underlying mechanisms of these interactions.
A new subtype of Lynch syndrome associated with MSH2 c.354T>A (p. Y118*) identified in a Chinese family: case report and literature review
Authors: Zhong Lan , Wang Wenxiang , Duan Yuanqiong , Song Liang , Li Zhanghuan , Yang Kaixuan , Li Qintong , Yin Rutie 
Published: October 2024

BackgroundLynch syndrome (LS) is an autosomal dominant inherited disorder caused by mutations in mismatch repair genes. Genetic counseling is crucial for the prevention and treatment of LS, as individuals with these mutations have an increased lifetime risk of developing multiple cancers. MutS Homolog 2 (MSH2) is a protein-coding gene that plays a key role in LS. A significant number of LS cases are linked to harmful heterozygous mutations in the MSH2 gene.Case PresentationThe proband was a 50-year-old endometrial dedifferentiated carcinoma patient with a dMMR/MSI-H tumor negative for MSH2/MSH6 expression by immunohistochemistry. Genetic counseling and tumor gene testing were conducted using next-generation sequencing (NGS) technology, which revealed a previously unknown germline MSH2 gene nonsense mutation NM_000251.2:exon2.354T&gt;A (p.Y118*), leading to a diagnosis of LS. Further analysis of this variant in five family members of the patient confirmed its presence in all individuals, with one family member being diagnosed with colorectal cancer (CRC) at the age of 43. The proband received postoperative chemoradiotherapy and achieved a disease-free survival of 2 years, with ongoing follow-up.ConclusionThis study provides evidence that the MSH2 nonsense mutation c.354T&gt;A is a highly likely pathogenic mutation and is responsible for typical LS-associated endometrial carcinoma. It emphasizes the importance of genetic counseling for proband family members to facilitate early diagnosis of LS-related carcinoma.
Comparative analysis of response surface methodology and adaptive neuro-fuzzy inference system for predictive fault detection and optimization in beverage industry
Authors: Onokwai Anthony O. , Olusanya Olamide O. , Onifade Morakinyo K. , Anyaegbuna Benjamin E. , Onoriode Avbenake , Agholor Darlington 
Published: October 2024

Maintenance is crucial for ensuring equipment reliability and minimizing downtime while managing associated costs. This study investigates a data-driven approach to predicting machine faults using Response Surface Methodology (RSM) and Adaptive Neuro-Fuzzy Inference System (ANFIS). RSM was employed to develop a mathematical model to analyze how operational parameters such as pressure, voltage, current, vibration, and temperature affect fault occurrence. Data were collected at three levels for each parameter using a central composite design. The model identified that faults peaked at a pressure of 28.38 N/m2, an operating voltage of 431.77 V, current consumption of 12.54 A, machine vibration of 47.17 Hz, and temperature of 25°C, with a maximum of 25 faults observed. Conversely, the lowest fault detection occurred at a pressure of 29.42 N/m2, an operating voltage of 441.04 V, current consumption of 12.04 A, machine vibration of 49.46 Hz, and temperature of 46.5°C. A strong correlation was found between these parameters and machine faults, with the model achieving high accuracy (R2 = 98.22%) and statistical significance (p-value &lt;0.05), demonstrating its reliability in predicting faults. The study also compared RSM with ANFIS for fault detection and process optimization in the beverage industry. While RSM effectively optimized parameter relationships, ANFIS, with its adaptive learning capabilities, provided superior fault prediction accuracy. This comparative analysis highlighted the strengths of both methods and suggested that integrating them could enhance predictive maintenance strategies. The findings offer valuable insights for industry practitioners, recommending a combined approach to improve fault detection, optimize production processes, and enhance operational efficiency.
Ocular manifestations for misdiagnosing acute angle closure secondary to lens subluxation
Authors: Wang Xinyu , Wang Qian , Song Wenqi , Yang Yu , Zhang Ruixuan , Lifen Gao , Lu Hui 
Published: October 2024

IntroductionThe objective of this study was to assess the clinical characteristics and biometric parameters, as measured by the IOLMaster, of patients suffering from acute secondary angle closure due to zonular dialysis (ASAC-ZD) who were misdiagnosed with acute primary angle closure (APAC).MethodsIn this retrospective study, 34 ASAC-ZD and 39 APAC eyes were examined. Sex, age, best-corrected visual acuity, axial length (AL), anterior chamber depth (ACD), anterior chamber depth standard deviation (ACDSD), lens thickness (LT), and lens thickness standard deviation (LTSD) were measured using the IOLMaster and compared between the two groups. In addition, the difference in ACD (ACD difference) between the affected eye and the contralateral eye was analyzed. Logistic regression analysis was performed to determine the predictive factors of lens subluxation. To determine the appropriate cutoff values for biometric parameters, ROC curves were constructed to distinguish between ASAC-ZD, APAC, and cataracts.ResultsCompared to the APAC group, the ASAC-ZD group was younger (69.92 ± 9.345, 63.74 ± 6.947), had longer AL (22.39 ± 0.7852, 23.23 ± 1.168), shallower ACD (2.120 ± 0.2986, 1.889 ± 0.5167), higher ACDSD (7.605 ± 5.425, 9.941 ± 6.120), higher LTSD (28.00 ± 19.52, 39.79 ± 22.74), and larger ACD differences (−0.1249 ± 0.2349, −0.7306 ± 0.5332) in the affected eye. Younger age, longer AL, lower ACD, higher LTSD, and higher ACD differences were associated with lens subluxation in the univariate logistic regression analysis. ACD difference (p = 0.0003), age (p = 0.0024), and ACD (p = 0.0491) were significantly associated with lens subluxation in the multivariable logistic regression analysis. Furthermore, the ROC curve analysis showed that the cutoff values for lens subluxation were a difference in ACD of 0.225 mm and 1.930 mm.ConclusionAsymmetric ACD in both eyes with normal AL and increasing ACDSD and LTSD may support the clinical diagnosis of lens subluxation.
Prescribing sustainability: should UN sustainable development goals be part of the medical, pharmacy, and biomedical education?
Authors: Wieërs Grégoire , Absil Simon , Maystadt Isabelle , Nicaise Charles , Modrie Pauline , Sibille François-Xavier , Melly Ludovic , Dogné Jean-Michel 
Published: October 2024

IntroductionHow to adapt the curriculum of medicine, pharmacy, and biomedical sciences to prepare future health professionals to meet the challenge of maintaining quality care in a period of socio-ecological crisis? Addressing connections between humanity and sustainable environment should include an analysis of the reciprocal influence of various ecosystems, since it is now clear that healthcare systems have an impact on ecosystems and vice versa. Here, we propose that integrating the United Nations Sustainable Development Goals (SDGs) into the curriculum could be a first step in such a transversal education.MethodsMembers of the faculty of medicine at the University of Namur, Belgium, including teaching staff of the department of medicine, pharmacy, biomedical sciences and psychology, were invited to respond anonymously to a questionnaire about their views on the feasibility of integrating the SDGs into their teaching. A subsequent survey on students’ perceptions of such teaching was conducted by student representatives.ResultsSeventy-nine percent of surveyed members of the medical faculty believe that it is possible to integrate SDGs into their lectures. However, 44–86% of them did not know how to integrate each individual goal. 94.4% of students would like SDGs to play a greater role in their education; 64.4% of them would integrate them into existing modules; 23.9% would create an optional module, and 11.9% would create a mandatory module.ConclusionSustainable Development Goals integration into the curriculum of medicine, pharmacy, and biomedical sciences is perceived as challenging in a dense teaching program. To clarify how SDGs can translate into traditional lectures, we provide for each SDG targeted applications for bachelor’s, master’s and continuing education.
Gait analysis in the early stage of Parkinson’s disease with a machine learning approach
Authors: Yin Wenchao , Zhu Wencheng , Gao Hong , Niu Xiaohui , Shen Chenxin , Fan Xiangmin , Wang Cui 
Published: October 2024

BackgroundGait disorder is a prominent motor symptom in Parkinson’s disease (PD), objective and quantitative assessment of gait is essential for diagnosing and treating PD, particularly in its early stage.MethodsThis study utilized a non-contact gait assessment system to investigate gait characteristics between individuals with PD and healthy controls, with a focus on early-stage PD. Additionally, we trained two machine learning models to differentiate early-stage PD patients from controls and to predict MDS-UPDRS III score.ResultsEarly-stage PD patients demonstrated reduced stride length, decreased gait speed, slower stride and swing speeds, extended turning time, and reduced cadence compared to controls. Our model, after an integrated analysis of gait parameters, accurately identified early-stage PD patients. Moreover, the model indicated that gait parameters could predict the MDS-UPDRS III score using a machine learning regression approach.ConclusionThe non-contact gait assessment system facilitates the objective and quantitative evaluation of gait disorder in PD patients, effectively distinguishing those in the early stage from healthy individuals. The system holds significant potential for the early detection of PD. It also harnesses gait parameters for a reasoned prediction of the MDS-UPDRS III score, thereby quantifying disease severity. Overall, gait assessment is a valuable method for the early identification and ongoing monitoring of PD.
Baseline and interim 18F-FDG PET/CT metabolic parameters predict the efficacy and survival in patients with diffuse large B-cell lymphoma
Authors: Liao Chengcheng , Deng Qifeng , Zeng Lin , Guo Baoping , Li Zhe , Zhou Da , Ke Qing , Wang Mingyue , Huang Mei , Tan Xiaohong , Cen Hong 
Published: October 2024

IntroductionThe prognostic value of 18F-FDG PET/CT metabolic parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), in diffuse large B-cell lymphoma (DLBCL) remains inadequately explored. This study aims to assess the correlation between these parameters and patient outcomes.MethodsA cohort of 156 DLBCL patients underwent 18F-FDG PET/CT imaging at baseline and after 3-4 cycles of R-CHOP or CHOP-like regimen. The third quartiles of liver uptake values were used as thresholds for calculating MTV and TLG. Patient outcomes were analyzed based on Ann Arbor staging and the 5-PS score. A nomogram was developed to predict overall survival (OS).ResultsPatients with low baseline TLG exhibited significantly better outcomes compared to those with high baseline TLG in both Ann Arbor stages I-II and III-IV (1-year PFS: 78.9% vs. 40%, p=0.016; OS: 94.7% vs. 40%, p=0.005 for stage I-II; 1-year PFS: 74.1% vs. 46.8%, p=0.014; OS: 85.4% vs. 71.8%, p=0.007 for stage III-IV). In interim PET/CT patients with a 5-PS score &gt;3, the high ΔTLG group had superior prognosis (1-year PFS: 82.3% vs. 35.7%, p=0.003; OS: 88.2% vs. 85.7%, p=0.003). The nomogram achieved a C-index of 0.9 for OS prediction.DiscussionThe findings suggest that baseline TLG is a robust prognostic indicator for patients with DLBCL, particularly in early stages, while ΔTLG effectively distinguishes those with favorable outcomes in higher-risk groups. These metabolic parameters from 18F-FDG PET/CT could enhance treatment decision-making and patient management strategies.
Impact of albumin infusion on prognosis in ICU patients with cirrhosis and AKI: insights from the MIMIC-IV database
Authors: Li Mengqi , Ge Yidi , Wang Jingjing , Chen Wenya , Li Jiashuo , Deng You , Xie Wen 
Published: October 2024

BackgroundAcute kidney injury (AKI) is common in cirrhotic patients, especially in the intensive care unit (ICU), and is often associated with poor prognosis. Albumin is often used for plasma volume expansion, but its efficacy in cirrhotic patients with AKI [excluding hepatorenal syndrome (HRS)] is debated. This study aimed to assess the impact of albumin therapy on prognosis in ICU patients with cirrhosis and non-HRS AKI.MethodsA retrospective analysis was conducted using the MIMIC-IV 2.2 database. The primary endpoint was 28-day mortality. Inverse probability of treatment weighting (IPTW) was used to balance baseline characteristics between the albumin and non-albumin groups.ResultsA total of 1,623 patients were included, with 586 receiving albumin. After IPTW, the sample sizes were 1,713 in the non-albumin group and 1,490 in the albumin group. Albumin administration was associated with higher rates of AKI recovery at 48 h but did not improve 28-day mortality in the overall cohort. Further analysis revealed that using 5% albumin concentration was associated with improved 28-day mortality (HR 0.68; 95% CI 0.49–0.95; p = 0.025), whereas 25% albumin did not show benefit. In patients with high bilirubin levels, albumin treatment significantly reduced 28-day mortality. However, albumin therapy may increase 28-day mortality in certain subgroups, including patients with chronic kidney disease and baseline albumin levels &gt;3.3 g/dL.ConclusionAlthough albumin therapy improved 28-day mortality in some cases, it may also increase mortality in certain subgroups. The use of albumin in critically ill patients with cirrhosis and AKI should be approached with greater consideration of its risks and benefits.
Effects of 8 days intake of hydrogen-rich water on muscular endurance performance and fatigue recovery during resistance training
Authors: Zhou Kaixiang , Yuan Chaoqun , Shang Zhangyuting , Jiao Wenhui , Wang Yubo 
Published: October 2024

BackgroundExercise-induced oxidative stress and inflammation can impair muscular function in humans. The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) highlight its potential to be as an effective nutritional supplement to support muscular function performance in healthy adults. However, the effects of H2 supplementation on muscular endurance performance in trained individuals have not been well characterized. This study aimed to assess the effects of intermittent hydrogen-rich water (HRW) supplementation before, during, and after resistance training on muscular endurance performance, neuromuscular status, and subjective perceptual responses after a 48-h recovery period.MethodsThis randomized, double-blinded, placebo-controlled cross-over study included 18 trained men aged 19.7 ± 0.9 years. Participants in this study were instructed to consume 1,920 mL of HRW or pure water (Placebo) daily for 7 days. Additionally, participants were required to supplement with HRW or pure water five times during the training day (1,260 mL total). This included drinking 210 mL 30 min and 1 min before training, 210 mL between training sets, 210 mL immediately after training, and 420 mL 30 min into the recovery period. Participants performed half-squat exercises with the load set at 70% of one repetition maximum for six sets (half-squat exercise performed to repetitions failure each set). We measured the power output and number of repetitions in the free barbell half-squat used to assess muscular endurance performance in participants. The countermovement jump (CMJ) height, total quality recovery scale (TQRS), and muscle soreness visual analog scale (VAS) scores were measured to assess fatigue recovery status after training, as well as at 24 and 48 h of recovery.ResultsThe total power output (HRW: 50,866.7 ± 6,359.9W, Placebo: 46,431.0 ± 9,376.5W, p = 0.032) and the total number of repetitions (HRW:78.2 ± 9.5 repetitions, Placebo: 70.3 ± 9.5 repetitions, p = 0.019) in the H2 supplemented group were significantly higher than in the placebo group. However, there was no statistically significant difference (p&lt; 0.05) between the H2 and placebo groups in CMJ, TQRS, and VAS.ConclusionEight days of intermittent HRW intake could significantly improve muscular endurance performance in trained individuals, making it a promising strategy for athletes or fitness enthusiasts looking to boost muscular endurance during resistance training or competitions. However, it should be noted that HRW intake alone may not be adequate to accelerate recovery from muscle soreness or fatigue following high-intensity training.
The effect of live-performed music therapy with physical contact in preterm infants on parental perceived stress and salivary cortisol levels
Authors: Dewan Monia Vanessa , Ader Miriam , Kleinbeck Tim , Dathe Anne-Kathrin , Schedlowski Manfred , Engler Harald , Felderhoff-Mueser Ursula , Bruns Nora , Kobus Susann 
Published: October 2024

IntroductionParents of preterm infants face a stressful life event which might have long term impact on the parent–child relation as well as on the infant’s cognitive and socio-emotional development. Both music therapy (MT) and physical contact (PC) are stress-reducing interventions for parents and preterm infants on the neonatal intensive care unit (NICU). Meanwhile, especially close PC is considered as standard care (SC) in most NICUs. However, the effect of live performed MT with PC on parental perceived stress and cortisol levels has barely been investigated. We hypothesized that MT with PC leads to reduced stress levels and lower salivary cortisol concentrations compared to SC in parents of preterm infants during the first 4 weeks after birth.MethodsRandomized-controlled trial enrolling the parents of 99 preterm infants (MT n = 50, SC n = 49 infants). The infants received either MT with PC or SC only. Perceived stress was measured with the perceived stress questionnaire 20 (PSQ-20) after birth and 4 weeks later. Salivary cortisol levels were obtained and measured weekly after birth for 4 weeks.ResultsForty-two mothers and eight fathers of the intervention group (MT with PC) as well as n = 43 mothers and n = 6 fathers of the control group (SC) were enrolled. For the intervention group, salivary cortisol was reduced 4 weeks after birth [mothers 5.5 nmol/l (confidence interval (CI) 3.6–7.5); fathers 8.3 (CI 7.2–9.4)] compared to the control group [mothers 10.3 nmol/l (CI 5.4–15.3); fathers 14.8 (CI 8.9–20.7)]. Overall perceived stress scores decreased in the intervention group (mothers −17.6; fathers −12.6) and increased in the control group (mothers +6.1; fathers +21.4) over 4 weeks.DiscussionLive-performed MT with PC in preterm infants might be an effective, non-invasive intervention to reduce parental stress and cortisol levels. Future studies should investigate the long-term effects of this intervention on the parent-infant relation as well as on the infants’ cognitive and socio-emotional development.Clinical trial registrationhttps://drks.de/search/en/trial/DRKS00025755 identifier [DRKS00025755].