bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Dehydroabietic Acid in Palladium‐Catalysed Enyne Cycloisomerisation
Authors: Wu Na , Li Ruikun , Cui Feihu , Pan Yingming 
Published: April 2017

AbstractDehydroabietic acid (DAA) promotes palladium(0)‐catalysed cyclisations of arene‐tethered 1,7‐enynols and 1,m‐enynoates (m=6,7) to give fused carbocyclic dienes. 6,6,6,5‐Tetracyclic lactones are accessible by one‐pot cycloisomerisation/Diels–Alder reaction/lactonisation from 1,7‐enynols. Furthermore, asymmetric counteranion‐directed catalysis has been developed, which afforded an indene derivative with an all‐carbon quaternary stereogenic center.magnified image
Superabsorbent nanocomposite based on maize bran with integration of water‐retaining and slow‐release NPK fertilizer
Authors: Olad Ali , Gharekhani Hamed , Mirmohseni Abdolreza , Bybordi Ahmad 
Published: April 2017

AbstractA novel fertilizer‐integrated superabsorbent nanocomposite based on maize bran (MB), acrylic acid (AA), and acrylamide (AAm) was synthesized in an aqueous solution containing montmorillonite (MMT) and NPK fertilizer compound. FTIR spectra indicated that hydroxyl group of the starch molecules in MB composition has participated in grafting reaction with acrylate‐based monomers. The swelling behavior of the synthesized hydrogels in different salt and pH solutions was evaluated. Also, the N,N′‐methylenebisacrylamide (MBA) and MMT contents were systematically optimized to obtain a highest swelling capacity. Fertilizer release assessments on the NPK‐loaded superabsorbent nanocomposite confirmed the effective role of MMT nanolayers in slow‐release property of the prepared formulation. Also, the prepared fertilizer formulation exhibited good water retention capacity in soil. As a result, this eco‐friendly and economical product can effectively reduce fertilizer loss, improve water utilization efficiency, and prolong irrigation cycles which are benefit for agricultural applications, especially in drought‐prone environments.
IgM myeloma: A multicenter retrospective study of 134 patients
Authors: Castillo Jorge J. , Jurczyszyn Artur , Brozova Lucie , Crusoe Edvan , Czepiel Jacek , Davila Julio , Dispenzieri Angela , Eveillard Marion , Fiala Mark A. , Ghobrial Irene M. , Gozzetti Alessandro , Gustine Joshua N. , Hajek Roman , Hungria Vania , Jarkovsky Jiri , Jayabalan David , Laubach Jacob P. , Lewicka Barbara , Maisnar Vladimir , Manasanch Elisabet E. , Moreau Philippe , Morgan Elizabeth A. , Nahi Hareth , Niesvizky Ruben , Paba‐Prada Claudia , Pika Tomas , Pour Ludek , Reagan John L. , Richardson Paul G. , Shah Jatin , Spicka Ivan , Vij Ravi , Waszczuk‐Gajda Anna , Gertz Morie A. 
Published: April 2017

AbstractIgM myeloma is a rare hematologic malignancy for which the clinicopathological features and patient outcomes have not been extensively studied. We carried out a multicenter retrospective study in patients with diagnosis of IgM myeloma defined by >10% marrow involvement by monoclonal plasma cells, presence of an IgM monoclonal paraproteinemia of any size, and anemia, renal dysfunction, hypercalcemia, lytic lesions and/or t(11;14) identified by FISH. A total of 134 patients from 20 centers were included in this analysis. The median age at diagnosis was 65.5 years with a male predominance (68%). Anemia, renal dysfunction, elevated calcium and skeletal lytic lesions were found in 37, 43, 19, and 70%, respectively. The median serum IgM level was 2,895 mg dL−1 with 19% of patients presenting with levels >6,000 mg dL−1. International Staging System (ISS) stages 1, 2, and 3 were seen in 40 (33%), 54 (44%), and 29 (24%) of patients, respectively. The malignant cells expressed CD20 (58%) and cyclin D1 (67%), and t(11;14) was the most common cytogenetic finding (39%). The median overall survival (OS) was 61 months. Higher ISS score was associated with worse survival (P = 0.02). Patients with IgM myeloma present with similar characteristics and outcomes as patients with more common myeloma subtypes.
Endoscopic endonasal nasopharyngectomy: tensor veli palatine muscle as a landmark for the parapharyngeal internal carotid artery
Authors: Liu Chiung‐Lin , Hsu Ning‐I , Shen Ping‐Hung 
Published: April 2017

BackgroundEndoscopic endonasal nasopharyngectomy(EEN) can be a promising option for select patients with recurrent nasopharyngeal carcinoma, but serious complications can occur in terms of parapharyngeal internal carotid artery (PPICA) injury. Several landmarks have been proposed for locating the PPICA. In this study, we investigated the spatial relationship between the tensor veli palatini (TVP) muscle and the PPICA in a cadaveric model.MethodsSeven fresh cadaver heads were available for anatomic study. Eustachian tube and the levator veli palatine (LVP) muscle were partially sacrificed or truncated to maximize the surgical field, and the TVP muscle was carefully preserved. Complete dissection was defined as when the PPICA could be visualized. We then measured the distance between the posterior margin of the TVP muscle and PPICA (z‐axis), and the distance from the midline of the nasopharynx to the PPICA (x‐axis).ResultsThirteen sides of the PPICA were successfully identified. The mean distance between the posterior margin of the TVP to the PPICA (z) was 20.3 mm (range, 12 to 28 mm), and the mean distance between the midline of the nasopharynx to the PPICA (x) was 19.6 mm (range, 15 to 24 mm).ConclusionThe PPICA was located in the same sagittal plane as the TVP muscle during dissection posteriorly. The PPICA appeared to lie around 2 cm laterally from the midline at around 2 cm in depth from the posterior margin of the TVP muscle. However, the exact position of the PPICA should be assessed using preoperative magnetic resonance imaging and intraoperative image‐guided systems.
Thermal and mechanical behavior evaluation of dental composites filled with irradiated montmorillonite
Authors: Campos L. M. P. , Zaharescu T. , Boaro L. C. , Santos L. K. G. , Santos T. M. R. , Ferreira H. P. , Parra D. F. 
Published: April 2017

ABSTRACTThe effects of pre‐irradiation treatment (dose ranged from 25 to 50 kGy) of MMT (Montmorillonite) nanoclay added as filler (50 wt %) in experimental dental composites was studied; composites containing similar amounts of non‐irradiated MMT were also tested. The thermal stability of the resulting material was tested by thermogravimetric analysis ranging from 50 to 800 °C. Elastic modulus and flexural strength were determined by the three point bending test (n = 10). Data for elastic modulus was analyzed using two way ANOVA/Tukey's test. Data for flexural strength was analyzed using Kruskal–Wallis/Tukey's test. For all tests, the global significance level was 5%. The modifications in elastic modulus and flexural strength with applied dose were characterized. X‐ray diffraction analysis allows the depicting of intercalation phenomenon between base‐polymer and nanophase. The polymeric system modified with MMT nanoparticles showed higher thermal stability by delaying the thermal degradation, compared to the control group, and the radiation dose influenced this thermal behavior directly. However, the applied dose was not sufficient to improve the mechanical properties significantly, which is related to the interaction between MMT and polymeric matrix. The pre‐irradiation treatment of MMT nanoclay phase was useful for attaining efficient interaction between the two constitutive phases of the polymeric systems based bis‐GMA/TEGDMA [bisphenol A bis(2‐hydroxy‐3‐methacryloxypropyl)ether/triethyleneglycol dimethacrylate], modified with MMT nanoparticles, because the polymer component was not affected. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45063.
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative
Authors: Aggarwal Rohit , Rider Lisa G. , Ruperto Nicolino , Bayat Nastaran , Erman Brian , Feldman Brian M. , Oddis Chester V. , Amato Anthony A. , Chinoy Hector , Cooper Robert G. , Dastmalchi Maryam , Fiorentino David , Isenberg David , Katz James D. , Mammen Andrew , de Visser Marianne , Ytterberg Steven R. , Lundberg Ingrid E. , Chung Lorinda , Danko Katalin , García‐De la Torre Ignacio , Song Yeong Wook , Villa Luca , Rinaldi Mariangela , Rockette Howard , Lachenbruch Peter A. , Miller Frederick W. , Vencovsky Jiri ,   for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation
Published: April 2017

ObjectiveTo develop response criteria for adult dermatomyositis (DM) and polymyositis (PM).MethodsExpert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on patient profiles using expert consensus (gold standard) and were validated using data from a clinical trial. The nominal group technique was used to reach consensus.ResultsConsensus was reached for a conjoint analysis–based continuous model using absolute percent change in core set measures (physician, patient, and extramuscular global activity, muscle strength, Health Assessment Questionnaire, and muscle enzyme levels). A total improvement score (range 0–100), determined by summing scores for each core set measure, was based on improvement in and relative weight of each core set measure. Thresholds for minimal, moderate, and major improvement were ≥20, ≥40, and ≥60 points in the total improvement score. The same criteria were chosen for juvenile DM, with different improvement thresholds. Sensitivity and specificity in DM/PM patient cohorts were 85% and 92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement, respectively. Definitions were validated in the clinical trial analysis for differentiating the physician rating of improvement (P < 0.001).ConclusionThe response criteria for adult DM/PM consisted of the conjoint analysis model based on absolute percent change in 6 core set measures, with thresholds for minimal, moderate, and major improvement.
Priority service needs and receipt across the lifespan for individuals with autism spectrum disorder
Authors: Lai Jonathan K. Y. , Weiss Jonathan A. 
Published: April 2017

AbstractIndividuals with Autism Spectrum Disorder (ASD) have a range of health, community, and social support needs across the lifespan that create age‐specific challenges in navigating service sectors. In this study, we set out to identify the priority needs of individuals with ASD across the lifespan, and the factors that predict receiving priority services. Participants included 3,317 individuals with ASD from a Canada‐wide online caregiver survey, stratified into five age groups (preschool, elementary school age, adolescence, emerging adulthood, adulthood). Priority receipt was calculated as a ratio of current services that corresponded to individualized priority need. Age‐stratified Poisson regression analyses were used to identify the sociodemographic, clinical and systemic predictors of priority receipt. Results indicate that the distribution of priority need varied by age, except for social skills programming, which was a high across all groups. The number of high and moderate priority needs diversified with age. Overall, 30% of individuals had none of their priority needs met and priority receipt decreased with age. Systemic factors were most consistently related to priority receipt across the lifespan. Understanding patterns and correlates of priority needs and use that currently exist in different age groups can inform policies to improve service access. Autism Res 2017, 10: 1436–1447. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.
Post surgery circulating free tumor DNA is a predictive biomarker for relapse of lung cancer
Authors: Hu Wenwei , Yang Yang , Zhang Longzhen , Yin Jianxin , Huang Jingwei , Huang Lei , Gu Hua , Jiang Gening , Fang Jianmin 
Published: April 2017

AbstractCancer cells release DNA fragments into plasma as circulating free DNA (cfDNA). However, quantitative measurement of tumor‐derived DNA in cfDNA remains challenge. The purpose of this study was to quantitatively assess tumor‐derived DNA in lung cancer patients. By optimizing competitive allele‐specific TaqMan PCR (CAST‐PCR), we assessed the copy number of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) and epidermal growth factor receptor (EGFR) alleles in the pre/post surgery plasma of 168 lung cancer patients. An absolute quantitative PCR method was developed to assess the number of total cfDNA. All mutations detected in tumors were also found in the plasma after surgery. At the time of 30 days after surgery, EGFR mutation of circulating cell‐free DNA was detected only in two patients who recurred in 4 months after surgery. Compared to that of normal control at 30 days after surgery, five patients who recurred in 4 months had significantly higher circulating cell‐free DNA (P < 0.001), whereas six patients who recurred after 4 months (P = 0.207) and five patients without recurrence (P = 0.901) demonstrated significantly lower circulating cell‐free DNA. Our findings suggest that cfDNA analysis in plasma is an alternative and supplement to tissue analysis and hold promise for clinical application. Stratification of patients according to cfDNA levels at 30 days after surgery might be helpful in selecting lung cancer patients for adjuvant therapy after surgery.
Nanomaterials in Electrochemiluminescence Sensors
Authors: Sun Jingwei , Sun Hao , Liang Ziqi 
Published: April 2017

AbstractElectrochemiluminescence (ECL) is a means of converting electrical energy into radiative energy. With combined advantages of chemiluminescence and electrochemical control, an interest in ECL has grown rapidly and is broadly applied in biological analysis. Recently, nanomaterials have been widely applied in the vast majority of ECL studies to remarkably amplify signals, owing to their excellent conductivity, large surface area, and sometimes catalytic activity. Herein, we present a Review article on novel nanomaterials in ECL sensors. We introduce the main types of nanomaterials and their physical, chemical, and biological properties along with applications in different ECL sensors with respect to the corresponding functions they serve. A major focus is placed upon numerous research strategies for addressing the signal amplification with nanomaterials in ECL. Lastly, a perspective on the challenges and opportunities of this emerging field is given.
d‐Cysteine Ligands Control Metal Geometries within De Novo Designed Three‐Stranded Coiled Coils
Authors: Ruckthong Leela , Peacock Anna F. A. , Pascoe Cherilyn E. , Hemmingsen Lars , Stuckey Jeanne A. , Pecoraro Vincent L. 
Published: April 2017

AbstractAlthough metal ion binding to naturally occurring l‐amino acid proteins is well documented, understanding the impact of the opposite chirality (d‐)amino acids on the structure and stereochemistry of metals is in its infancy. We examine the effect of a d‐configuration cysteine within a designed l‐amino acid three‐stranded coiled coil in order to enforce a precise coordination number on a metal center. The d chirality does not alter the native fold, but the side‐chain re‐orientation modifies the sterics of the metal binding pocket. l‐Cys side chains within the coiled‐coil structure have previously been shown to rotate substantially from their preferred positions in the apo structure to create a binding site for a tetra‐coordinate metal ion. However, here we show by X‐ray crystallography that d‐Cys side chains are preorganized within a suitable geometry to bind such a ligand. This is confirmed by comparison of the structure of ZnIICl(CSL16DC)32− to the published structure of ZnII(H2O)(GRAND‐CSL12AL16LC)3−. Moreover, spectroscopic analysis indicates that the CdII geometry observed by using l‐Cys ligands (a mixture of three‐ and four‐coordinate CdII) is altered to a single four‐coordinate species when d‐Cys is present. This work opens a new avenue for the control of the metal site environment in man‐made proteins, by simply altering the binding ligand with its mirror‐imaged d configuration. Thus, the use of non‐coded amino acids in the coordination sphere of a metal promises to be a powerful tool for controlling the properties of future metalloproteins.
Molekülmodelle einfach selbst gebaut
Authors: Quadbeck‐Seeger H.‐J. 
Published: April 2017

ZusammenfassungAusgehend von der Frage, welche Möglichkeiten das Moletomics‐Konzept über die Organische Chemie hinaus noch bietet, führte der Weg zu Anorganischen Strukturen sowie zu einer neuen Methode, komplexe geometrische Körper herzustellen. Das Einschmelzen von Draht in Plastik‐Perlen führt zur festen Verbindung der Teile, die das Löten ersetzt und die Arbeit sehr erleichtert. Die neue Methode, beschichtete Gitterdrähte und die Kunststoff‐Röhrchen von Wattestäbchen zu nutzen, erweitert die Möglichkeiten nochmals enorm. Es sind keine besonderen Fertigkeiten oder Materialien notwendig. Zugleich bietet sich die Möglichkeit, maßstabsgetreue Molekülmodelle mit nahezu wissenschaftlicher Präzision zu erstellen.
Organic, Organometallic and Bioorganic Catalysts for Electrochemical Reduction of CO2
Authors: Apaydin Dogukan Hazar , Schlager Stefanie , Portenkirchner Engelbert , Sariciftci Niyazi Serdar 
Published: April 2017

AbstractA broad review of homogeneous and heterogeneous catalytic approaches toward CO2 reduction using organic, organometallic, and bioorganic systems is provided. Electrochemical, bioelectrochemical and photoelectrochemical approaches are discussed in terms of their faradaic efficiencies, overpotentials and reaction mechanisms. Organometallic complexes as well as semiconductors and their homogeneous and heterogeneous catalytic activities are compared to enzymes. In both cases, their immobilization on electrodes is discussed and compared to homogeneous catalysts in solution.
High‐Risk Screening for Fabry Disease: Analysis by Tandem Mass Spectrometry of Globotriaosylceramide (Gb3) in Urine Collected on Filter Paper
Authors: Auray‐Blais Christiane , Lavoie Pamela , Boutin Michel , Abaoui Mona 
Published: April 2017

AbstractFabry disease is a complex, panethnic lysosomal storage disorder. It is characterized by the accumulation of glycosphingolipids in tissues, organs, the vascular endothelium, and biological fluids. The reported incidence in different populations is quite variable, ranging from 1:1400 to 1:117,000. Its complexity lies in the marked genotypic and phenotypic heterogeneity. Despite the fact that it is an X‐linked disease, more than 600 mutations affect both males and females. In fact, some females may be affected as severely as males. The purpose of this protocol is to focus on the high‐risk screening of patients who might have Fabry disease using a simple, rapid, non‐invasive high performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS) method for urinary globotriaosylceramide (Gb3) analysis. Urine filter paper samples are easily collected at home by patients and sent by regular mail. This method has been successfully used for high‐risk screening of patients with ophthalmologic manifestations and in an on‐going study for high‐risk screening of Fabry disease in patients with chronic kidney diseases. © 2017 by John Wiley & Sons, Inc.
Benzothiadiazole‐Based Small‐Molecule Semiconductors for Organic Thin‐Film Transistors and Complementary‐like Inverters
Authors: Kim Hyekyoung , Reddy M. Rajeshkumar , Kim Hyungsug , Choi Donghee , Kim Choongik , Seo SungYong 
Published: April 2017

AbstractNew benzothiadiazole derivatives, 4,7‐bis(5‐phenylthiophen‐2‐yl)benzo[c][1,2,5]thiadiazole (PT‐BTD) and 4,7‐bis[4‐(thiophen‐2‐yl)phenyl]benzo[c][1,2,5]thiadiazole (TP‐BTD), were synthesized and characterized as small‐molecule organic semiconductors for organic thin‐film transistors (OTFTs) and complementary inverters. The thermal, optical, and electrochemical properties of the new compounds were fully characterized. Vacuum‐deposition and solution‐shearing methods were used to fabricate thin films based on these compounds. Thin films based on PT‐BTD exhibited p‐channel characteristics with hole mobilities as high as 0.10 cm2 V−1 s−1 and current on/off ratios >107 for top‐contact/bottom‐gate OTFT devices. With an optimized blending ratio of PT‐BTD and the representative n‐channel semiconductor N,N′‐1H,1H‐perfluorobutyl dicyanoperylenediimide, bulk heterojunction ambipolar transistors were fabricated with balanced hole and electron mobilities of 0.10 and 0.07 cm2 V−1 s−1, respectively. Furthermore, a complementary‐like inverter was fabricated using ambipolar thin‐film transistors, which showed a high voltage gain of 84.
Facile Synthesis of Rod‐like Cu2−xSe and Insight into its Improved Lithium‐Storage Property
Authors: Li He , Jiang Jiali , Wang Feng , Huang Jianxing , Wang Yunhui , Zhang Yiyong , Zhao Jinbao 
Published: April 2017

AbstractA rod‐like Cu2−xSe is synthesized by a facile water evaporation process. The electrochemical reaction mechanism is investigated by ex situ X‐ray diffraction (XRD). By adopting an ether‐based electrolyte instead of a carbonate‐based electrolyte, the electrochemical performance of Cu2−xSe electrodes improved significantly. The Cu2−xSe electrodes exhibit outstanding cycle performance: after 1000 cycles, 160 mA h g−1 can be maintained with a retention of 80.3 %. At current densities of 100, 200, 500, and 1000 mA g−1, the capacity of a Cu2−xSe/Li battery was 208, 202, 200, and 198 mA h g−1, respectively, showing excellent rate capability. The 4‐probe conductivity measurements along with electrochemical impendence spectroscopy (EIS) and cyclic voltammetry (CV) tests illustrate that the Cu2−xSe electrodes display high specific conductivity and impressive lithium–ion diffusion rate, which makes the Cu2−xSe a promising anode material for lithium–ion batteries.
A dissociation between renewal and contextual fear conditioning in juvenile rats
Authors: Park Chun Hui J. , Ganella Despina E. , Kim Jee Hyun 
Published: April 2017

AbstractWe investigated whether juvenile rats do not express renewal following extinction of conditioned fear due to their inability to form a long‐term contextual fear memory. In experiment 1, postnatal day (P) 18 and 25 rats received 3 white‐noise and footshock pairings, followed by 60 white‐noise alone presentations the next day. When tested in a different context to extinction, P25 rats displayed renewal whereas P18 rats did not. Experiments 2A and 2B surprisingly showed that P18 and P25 rats do not show differences in contextual and cued fear, regardless of the conditioning‐test intervals and the number of white‐noise‐footshock pairings received. Finally, we observed age differences in contextual fear when P25 rats were weaned at P21 in experiment 3. These results indicate that the developmental dissociation observed in renewal of extinguished fear is not related to the widely believed late emergence of contextual fear learning.