bluuebunny/crossref_metadata_2025_split huggingface dataset:
Replication analysis of 15 susceptibility loci for nonsyndromic cleft lip with or without cleft palate in an italian population
Authors: Cura Francesca , Böhmer Anne C. , Klamt Johanna , Schünke Hannah , Scapoli Luca , Martinelli Marcella , Carinci Francesco , Nöthen Markus M. , Knapp Michael , Ludwig Kerstin U. , Mangold Elisabeth 
Published: December 2015

BACKGROUNDNonsyndromic cleft lip with or without cleft palate (nsCL/P) is one of the most common congenital malformations in humans. Its average global incidence is 1.7 per 1000 live births, with wide variation according to geographical location and ethnicity. Its etiology involves both genetic and environmental factors. The aim of the present study was to confirm genetic association of a selection of 15 candidate nsCL/P loci using an independent sample of the Italian population.METHODSAt least one single‐nucleotide polymorphism (SNP) for each locus was genotyped in 380 nuclear trios.RESULTSTransmission disequilibrium analysis revealed significant associations for three variants at two loci (8q24 and 1p22). Two SNPs at 8q24 showed the strongest level of association, the rs987525 (PTDT = 6.81 × 10−6; homozygous relative risk = 3.60 [95% confidence interval, 2.12–6.13]), and the rs17241253 (PTDT = 1.03 × 10−5; homozygous relative risk = 3.75 [95% confidence interval, 2.10–6.67]). Four additional loci (at 1q32, 3q12, 8q21, and 10q25) achieved nominally significantp‐values. Two SNPs at 1p36 achievedp‐values of < 0.1. The present data suggest that 6 of the 15 analyzed nsCL/P risk loci contribute significantly to nsCL/P risk in the Italian population. These include the 1p22 locus, which previous research has implicated predominantly in Asian populations.CONCLUSIONDifferent loci, including 8q24 and 1p22 have been found associated with nsCL/P in multiple populations. Further efforts are needed to identify causative variants and transfer knowledge to clinical application, such as personal genetic risk assessment. Birth Defects Research (Part A) 106:81–87, 2016. © 2015 Wiley Periodicals, Inc.
Spin Crossover, Polymorphism and Porosity to Liquid Solvent in Heteroleptic Iron(III) {Quinolylsalicylaldimine/Thiosemicarbazone‐Salicylaldimine} Complexes
Authors: Phonsri Wasinee , Davies Casey G. , Jameson Guy N. L. , Moubaraki Boujemaa , Murray Keith S. 
Published: December 2015

AbstractHeteroleptic iron(III) complexes of formula [Fe(qsal)(thsa)]⋅solvent have been synthesized: [Fe(qsal)(thsa)]⋅0.4 BuOH (1), [Fe(qsal)(thsa)]⋅0.5 MeCN (2) and [Fe(qsal)(thsa)]⋅0.5 THF, (3). The latter two show partial solvent loss at room temperature to yield [Fe(qsal)(thsa)]⋅0.1 MeCN (2′) and [Fe(qsal)(thsa)]⋅0.1 THF (3′), respectively. This family maintains a structural integrity which is analogous over different degrees of solvation, a rare occurrence in discrete molecular species. Uniquely, removal of MeCN from compound 2 leads to retention of crystallinity yielding the isostructural, fully desolvated compound [Fe(qsal)(thsa)] (2′′) and a new high spin polymorph, 4. To the best of our knowledge, this is the first compound that forms polymorphs through a desolvation process. The desolvated mixture, 2′′ and 4, is porous and can reabsorb MeCN and give rise to 2′ again. This illustrates the reversible single‐crystal‐to‐single‐crystal transformation of two polymorphs back to a purely original phase, 2′′+4↔2′. The structural, magnetic and Mőssbauer features of the various samples are described in terms of spin crossover.
Solid‐State Molecular Nanomagnet Inclusion into a Magnetic Metal–Organic Framework: Interplay of the Magnetic Properties
Authors: Mon Marta , Pascual‐Álvarez Alejandro , Grancha Thais , Cano Joan , Ferrando‐Soria Jesús , Lloret Francesc , Gascon Jorge , Pasán Jorge , Armentano Donatella , Pardo Emilio 
Published: December 2015

AbstractInvited for the cover of this issue is the group of Emilio Pardo at the University of València and his collaborators. The image depicts the solid‐state incorporation of a metalloporphyrin within the pores of a magnetic metal–organic framework. Read the full text of the article at 10.1002/chem.201504176.
RESPONSE OF PRECIPITATION AND ITS EXTREMES OVER CHINA TO WARMING: CMIP5 SIMULATION AND PROJECTION
Authors: Jia WU , Bo‐Tao ZHOU , Ying XU 
Published: December 2015

AbstractBased on 24 Coupled Model Intercomparison Project Phase 5 (CMIP5) models simulations, the responses of annual precipitation and precipitation extremes (R95p and R99p defined by ETCCDI) to warming in China are analyzed. Quantitative analysis shows that the CMIP5 multi‐model ensemble (MME) underestimates the response of precipitation while overestimates the response of precipitation extremes over China region in historical period. It also has abilities in reproducing the relationships between the precipitation, precipitation extremes and the warming over subregions of China, and better performance can be found in precipitation extremes. Concurrent with the warming under the RCP4.5 and RCP8.5 scenarios, the precipitation and precipitation extremes are projected to increase consistently over China. Under the RCP4.5 and RCP8.5 scenarios, as the regional mean temperature rises by 1°C, the precipitation will increase by 3.5% and 2.4%, and the R95p will increase by 8.0% and 11.9%, respectively. The response of R99p is much more sensitive respectively with an increase of 15.3% and 21.6%. For subregions of China, they all show positive response and the regional difference will decrease in the future. Moreover, the sensitivity of the precipitation extremes to the warming is higher than that of the mean precipitation. The stronger the precipitation extreme is, the higher sensitivity it will have. Besides, the response of the mean precipitation to the warming is larger in Northern China than in Southern China. The largest increases in R95p and R99p are projected in the Tibetan Plateau and Southwest China, indicating an increased risk of heavy rainfall and floods.
3‐D DENSITY DISTRIBUTION OF THE CRUST AND UPPER MANTLE BENEATH NORTHEAST CHINA BY JOINT INVERSION OF GRAVITY AND SEISMIC DATA
Authors: Kui SUO , Gui‐Bin ZHANG , Guo‐Ming JIANG , Yao XU 
Published: December 2015

AbstractWe obtain a three‐dimensional (3‐D) density structure in the crust and the upper‐mantle beneath Northeast China through a joint inversion of gravity and P‐wave travel time data. Compared to inversions of gravity or seismic data alone, the joint inversion can not only increase the vertical resolution of the gravity inversion, but also improve the reliability of the seismic inversion. Our inversion shows two results. First, the residual density anomalies in the crust and the upper‐mantle correlate with the tectonics quite well: the orogen corresponds to low density whereas the basin corresponds to high density. Second, the areas beneath volcanoes have low density. One explanation is that the partial dehydrated Pacific slab was stagnant in the process of subducting into the mantle transition zone, and the hot material in the upper‐mantle generated the upwelling magma and caused the volcano eruption.
Correlation between Electrochemical Impedance and Spectroscopic Measurements in Adsorbing Paraquat on Silver: Application in Underground Water Samples
Authors: Lahrich S. , Hammani H. , Boumya W. , Loudiki A. , Farahi A. , Achak M. , Bakasse M. , El Mhammedi M. A. 
Published: December 2015

AbstractThe electrochemical impedance spectroscopy (EIS) has been used to study the interaction between paraquat and carbon modified by silver (AgCPE) and silver particles‐impregnated natural phosphate (Ag/NPhCPE). This study was developed using spectrophotometry (UVVis) and infrared spectroscopy. The resulting interaction was controlled by adsorption at lower concentration (≤1.0×10−5 mol L−1) and by diffusion in the opposite case. Both electrodes are used to determining paraquat with a low detection limit (<1.0×10−12 mol L−1). The precision expressed as relative standard deviation RSD for the concentration level 1.0×10−5 mol L−1 of paraquat, (n=8) were 0.93 % and 1.1 % for Ag/NPhCPE and AgCPE respectively.
Influence of lithostratigraphy on the retreat of an unconsolidated sedimentary coastal cliff (St. Lawrence estuary, eastern Canada)
Authors: Joyal Gabriel , Lajeunesse Patrick , Morissette Antoine , Bernatchez Pascal 
Published: December 2015

AbstractThis paper investigates the processes involved in unconsolidated cliff recession using LiDAR surveys (2005, 2010 and 2013) and aerial photographs (1964–2012) at Pointe‐au‐Bouleau, on the north shore of the St. Lawrence estuary, in eastern Canada. The high lithostratigraphic variability of the sediments allowed for the identification of stratigraphic and lithological variables that explain the evolution of coastal cliffs. Space‐for‐time substitution was also used to assess how lithostratigraphy controls the evolution of emerged glaciomarine coastal cliffs over decadal to centennial timescales. This case study presents new quantitative data that contributes to a better understanding of the role of sediment architecture, stratigraphy and geomorphology on coastal evolution. The methodological approach includes the development of a new conceptual model suitable for identifying erosion on cliff coastlines. The high spatial resolution methodology (<5 cm) used herein demonstrates the need for further research using LiDAR data in order to quantify the processes involved in the evolution of coastal cliffs. Copyright © 2015 John Wiley & Sons, Ltd.
Reconstituted high‐density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component
Authors: Herzog Eva , Pragst Ingo , Waelchli Marcel , Gille Andreas , Schenk Sabrina , Mueller‐Cohrs Jochen , Diditchenko Svetlana , Zanoni Paolo , Cuchel Marina , Seubert Andreas , Rader Daniel J. , Wright Samuel D. 
Published: December 2015

AbstractHuman apolipoprotein A‐I preparations reconstituted with phospholipids (reconstituted high‐density lipoprotein [HDL]) have been used in a large number of animal and human studies to investigate the physiological role of apolipoprotein A‐I. Several of these studies observed that intravenous infusion of reconstituted HDL might cause transient elevations in plasma levels of hepatic enzymes. Here we describe the mechanism of this enzyme release. Observations from several animal models and in vitro studies suggest that the extent of hepatic transaminase release (alanine aminotransferase [ALT]) correlates with the movement of hepatic cholesterol into the blood after infusion. Both the amount of ALT release and cholesterol movement were dependent on the amount and type of phospholipid present in the reconstituted HDL. As cholesterol is known to dissolve readily in phospholipid, an HDL preparation was loaded with cholesterol before infusion into rats to assess the role of diffusion of cholesterol out of the liver and into the reconstituted HDL. Cholesterol‐loaded HDL failed to withdraw cholesterol from tissues and subsequently failed to cause ALT release. To investigate further the role of cholesterol diffusion, we employed mice deficient in SR‐BI, a transporter that facilitates spontaneous movement of cholesterol between cell membranes and HDL. These mice showed substantially lower movement of cholesterol into the blood and markedly lower ALT release. We conclude that initial depletion of hepatic cholesterol initiates transient ALT release in response to infusion of reconstituted HDL. This effect may be controlled by appropriate choice of the type and amount of phospholipid in reconstituted HDL. Copyright © 2015 John Wiley & Sons, Ltd.
High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography
Authors: Azinfar Leila , Ravanfar Mohammadreza , Wang Yuanbo , Zhang Keqing , Duan Dongsheng , Yao Gang 
Published: December 2015

The biomechanical properties of artery are primarily determined by the fibrous structures in the vessel wall. Many vascular diseases are associated with alternations in the orientation and alignment of the fibrous structure in the arterial wall. Knowledge on the structural features of the artery wall is crucial to our understanding of the biology of vascular diseases and the development of novel therapies. Optical coherence tomography (OCT) and polarization‐sensitive OCT have shown great promise in imaging blood vessels due to their high resolution, fast acquisition, good imaging depth, and large field of view. However, the feasibility of using OCT based methods for imaging fiber orientation and distribution in the arterial wall has not been investigated. Here we show that the optical polarization tractography (OPT), a technology developed from Jones matrix OCT, can reveal the fiber orientation and alignment in the bovine common carotid artery. The fiber orientation and alignment data obtained in OPT provided a robust contrast marker to clearly resolve the intima and media boundary of the carotid artery wall.
Optical polarization tractography can visualize fiber orientation and alignment in carotid artery.magnified imageOptical polarization tractography can visualize fiber orientation and alignment in carotid artery.
Carpal arch and median nerve changes during radioulnar wrist compression in carpal tunnel syndrome patients
Authors: Marquardt Tamara L. , Evans Peter J. , Seitz William H. , Li Zong‐Ming 
Published: December 2015

ABSTRACTThe purpose of this study was to investigate the morphological changes of the carpal arch and median nerve during the application of radiounlarly directed compressive force across the wrist in patients with carpal tunnel syndrome. Radioulnar compressive forces of 10 N and 20 N were applied at the distal level of the carpal tunnel in 10 female patients diagnosed with carpal tunnel syndrome. Immediately prior to force application and after 3 min of application, ultrasound images of the distal carpal tunnel were obtained. It was found that applying force across the wrist decreased the carpal arch width (p < 0.001) and resulted in increased carpal arch height (p < 0.01), increased carpal arch curvature (p < 0.001), and increased radial distribution of the carpal arch area (p < 0.05). It was also shown that wrist compression reduced the flattening of the median nerve, as indicated by changes in the nerve's circularity and flattening ratio (p < 0.001). This study demonstrated that the carpal arch can be non‐invasively augmented by applying compressive force across the wrist, and that this strategy may decompress the median nerve providing symptom relief to patients with carpal tunnel syndrome. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1234–1240, 2016.
Poly(Amido Amine)s Containing Agmatine and Butanol Side Chains as Efficient Gene Carriers
Authors: Won Young‐Wook , Ankoné Marc , Engbersen Johan F. J. , Feijen Jan , Kim Sung Wan 
Published: December 2015

A new type of bioreducible poly(amido amine) copolymer is synthesized by the Michael addition polymerization of cystamine bisacrylamide (CBA) with 4‐aminobutylguanidine (agmatine, AGM) and 4‐aminobutanol (ABOL). Since the positively charged guanidinium groups of AGM and the hydroxybutyl groups of ABOL in the side chains have shown to improve the overall transfection efficiency of poly(amido amine)s, it is hypothesized that poly(CBA‐ABOL/AGM) synthesized at the optimal ratio of both components would result in high transfection efficiency and minimal toxicity. In this study, a series of the poly(CBA‐ABOL/AGM) copolymers is synthesized as gene carriers. The polymers are characterized and luciferase transfection efficiencies of the polymers in various cell lines are investigated to select the ideal ratio between AGM and ABOL. The poly(CBA‐ABOL/AGM) containing 80% AGM and 20% ABOL has shown the best transfection efficiency with the lowest cytotoxicity, indicating that this polymer is very promising as a potent and nontoxic gene carrier.
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Tailoring Optical Properties of π‐Conjugated Statistical Co‐Oligomers Composed of 3‐Pentylthiophene and 3‐[(E)‐2‐(1‐Naphthyl)­vinyl]thiophene through the Monomer Ratio in the Main Chain
Authors: Andryszewski Tomasz , Czerwinski Wojciech , Fialkowski Marcin 
Published: December 2015

Synthesis and characterization of π‐conjugated homo‐ and co‐oligomers based on thiophene substituted in position 3 by pentyl (3PT) and naphthylvinyl (NVT) side groups are presented. The resultant co‐oligomers have statistical structure and the proportion of monomers can be fully controlled by the composition of the reaction mixture. The approach here offers a facile way to synthesis of materials with tunable optoelectrical properties that is an alternative for complicated organometallic synthesis involving water and oxygen sensitive Sn, Pd, or Mg compounds. The UV–vis absorption and fluorescence emission spectra depend on and can be easily tuned by the [3PT]:[NVT] monomer molar ratio. Combination of these two monomers has a strong synergistic effect on the color of the fluorescence emission that varies in a broad range, from orange to blue color. X‐ray diffraction, calorimetric, and materials display electrical properties characteristic for organic semiconductors.
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Bioactive Nanofiber Matrices Functionalized with Fibronectin‐Mimetic Peptides Driving the Alignment and Tubular Commitment of Adult Renal Stem Cells
Authors: Sciancalepore Anna G. , Moffa Maria , Carluccio Simonetta , Romano Luigi , Netti Giuseppe S. , Prattichizzo Clelia , Pisignano Dario 
Published: December 2015

Bioactive, electrospun polymer nanofibers (NFs) are attractive building‐block materials for realizing scaffolds for tissue engineering, as these filaments structurally mimic the hierarchical organization of natural extracellular matrix. As presented in this article, demonstrated applications involve the commitment to adipogenic, chondrogenic, osteogenic, neural lineages, and so on, by different types of stem cells obtained from various sources (adult, embryonic, induced pluripotent stem cells, etc.). Since a poor cellular colonization may limit the usefulness of scaffolds for culturing delicate stem cell populations, coupling NFs with cell‐adhesive domains is highly desirable. In our work, the surface of either isotropic (randomly oriented) or anisotropic (highly aligned) electrospun poly(l‐lactic acid) fibrous scaffolds with fibronectin (FN)‐mimetic peptides is tailored. The effects of the peptide immobilization on the adhesion and spreading of human, adult renal stem cells are investigated. Functionalized, aligned NFs are suitable scaffolds to promote the confluent growth of stem cells and to enhance their differentiation toward the tubular epithelial lineage. It is anticipated that the functionalization of aligned NFs with FN‐mimetic peptides might be a promising method to target a specific response of stem cells in renal tissue engineering.
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Neurohistiocytosis of the Cerebellum: A Rare Cause of Ataxia
Authors: Elkouzi Ahmad , Rauschkolb Paula , Grogg Karen L. , Gilchrist James M. 
Published: December 2015

AbstractErdheim‐Chester disease (ECD) is a non‐Langerhans cell histiocytosis that affects multiple body organs, notably the skeletal system. We examined a 58‐year‐old man who presented with ataxia and T2 hyperintensity of the middle cerebellar peduncles and dentate nuclei without contrast enhancement on MRI brain. Workup for malignancy revealed “hairy kidneys” on CT scan of the abdomen, and excisional biopsy of the retroperitoneal mass for concerns of lymphoma revealed foamy histiocytes that tested positive for CD68 and negative for CD1a, confirming the diagnosis of ECD. Further genetic testing on excised tissue revealed BRAF (V600E) gene mutation that is present in 50% of ECD patients. Treatment was initiated with targeted therapy using the BRAF inhibitor Dabrafenib. X‐ray of the lower extremities did not reveal sclerosis of the long bones, and bone scan with technetium 99 was negative except for a nonspecific tracer uptake in left calvarial bone with no corresponding CT changes or T1/T2 signal changes on MRI. His MRI brain revealed classic cerebellar involvement in ECD without other central nervous system (CNS) involvement. It has been postulated that bone involvement is almost universal in ECD; however, our patient with ECD had ataxia and cerebellar involvement without significant bone involvement, as evidenced by bone scan. This is a rare presentation of ECD affecting the CNS and sparing the skeletal system. It confirms the wide spectrum of presentation this multisystem disease can have.
Dynamic changes in the sperm quality ofMytilus galloprovincialisunder continuous thermal stress
Authors: Boni Raffaele , Gallo Alessandra , Montanino Melania , Macina Alberto , Tosti Elisabetta 
Published: December 2015

SUMMARYGlobal warming is an increasingly serious problem underlying ecological change in marine flora and fauna.Mytilus galloprovincialisis an intertidal species that colonizes coasts in moderate and warm climates, and can thus withstand extreme climatic conditions; however, it successfully reproduces only within a certain temperature range. The effects of prolonged exposure to 28°C, a temperature unsuitable for breeding activity, on sperm quality were evaluated in this study. Such heat stress induced the following: a significant reduction in concentration; a biphasic pattern of motility and mitochondrial membrane potential that first increased, and then collapsed; a decrease in the intracellular calcium concentration; a rapid increase in lipid peroxidation that was normalized after the third week of heat stress; an increase in DNA fragmentation after the third week of heat stress; and atypical morphology (i.e., sperm with a globular head, asymmetrical tail, and acrosome loss). Currently, these elevated‐temperature conditions are achieved along the Mediterranean coast during the late summer, when the reproductive activity ofM. galloprovincialisis suspended after massive spawning in the spring. The increasing global temperature, however, may shift their breeding season, thus significantly impacting marine ecosystems and mussel production.Mol. Reprod. Dev. 83: 162–173, 2016. © 2015 Wiley Periodicals, Inc.
Sleep Hygiene and Sleep Quality of Third‐Trimester Pregnant Women
Authors: Tsai Shao‐Yu , Lee Chien‐Nan , Wu Wei‐Wen , Landis Carol A. 
Published: December 2015

AbstractThe purpose of this descriptive study was to examine the associations of sleep hygiene and actigraphy measures of sleep with self‐reported sleep quality in 197 pregnant women in northern Taiwan. Third‐trimester pregnant women completed the Sleep Hygiene Practice Scale (SHPS) and the Pittsburgh Sleep Quality Index (PSQI) as well as the Center for Epidemiologic Studies‐Depression Scale (CES‐D), and wore an actigraph for 7 consecutive days. Student's t‐test was used to compare the SHPS scores and means as well as variability of actigraphy sleep variables between poor sleepers (i.e., PSQI global score >5) and good sleepers (i.e., PSQI global score ≤5). Compared to good sleepers, poor sleepers reported significantly worse sleep hygiene, with higher SHPS scores and higher sleep schedule, arousal‐related behavior, and sleep environment subscale scores. Poor sleepers had significantly greater intra‐individual variability of sleep onset latency, total nighttime sleep, and wake after sleep onset than good sleepers. In stepwise linear regression, older maternal age (p = .01), fewer employment hours per week (p = .01), higher CES‐D total score (p < .01), and higher SHPS arousal‐related behavior subscale scores (p < .01) predicted self‐reported global sleep quality. Findings support avoiding physically, physiologically, emotionally, or cognitively arousing activities before bedtime as a target for sleep‐hygiene intervention in women during pregnancy. © 2015 Wiley Periodicals, Inc.