bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heteroplasmy due to coexistence of mtCOI haplotypes from different lineages of theThrips tabacicryptic species group
Authors: Gawande S.J. , Anandhan S. , Ingle A.A. , Jacobson Alana , Asokan R. 
Published: January 2017

AbstractHeteroplasmy is the existence of multiple mitochondrial DNA haplotypes within the cell. Although the number of reports of heteroplasmy is increasing for arthropods, the occurrence, number of variants, and origins are not well studied. In this research, the occurrence of heteroplasmy was investigated inThrips tabaci, a putative species complex whose lineages can be distinguished by their mitochondrial DNA haplotypes. The results from this study showed that heteroplasmy was due to the occurrence of mitochondrial cytochrome oxydase I (mtCOI) haplotypes from two differentT. tabacilineages. An assay using flow cytometry and quantitative real-time PCR was then used to quantify the per cell copy number of the two mtCOI haplotypes present in individuals exhibiting heteroplasmy from nine geographically distant populations in India. All of theT. tabaciindividuals in this study were found to exhibit heteroplasmy, and in every individual the per cell copy number of mtCOI from lineage 3 comprised 75–98% of the haplotypes detected and was variable among individuals tested. There was no evidence to suggest that the presense of lineage-specific haplotypes was due to nuclear introgression; however, further studies are needed to investigate nuclear introgression and paternal leakage during rare interbreeding between individuals from lineages 2 and 3.
Sit, step, sweat: longitudinal associations between physical activity patterns, anxiety and depression
Authors: Hiles S. A. , Lamers F. , Milaneschi Y. , Penninx B. W. J. H. 
Published: January 2017

BackgroundPhysical inactivity has been identified as a risk factor for depression and, less often, as a long-term consequence of depression. Underexplored is whether similar bi-directional longitudinal relationships are observed for anxiety disorders, particularly in relation to three distinct indicators of activity levels – sports participation, general physical activity and sedentary behavior.MethodParticipants were from the Netherlands Study of Depression and Anxiety (NESDA; N = 2932, 18–65 years old; 57% current anxiety or depressive disorder, 21% remitted disorder, 22% healthy controls). At baseline, 2, 4, and 6 years, participants completed a diagnostic interview and self-report questionnaires assessing psychopathology symptom severity, physical activity indicators, and sociodemographic and health covariates.ResultsConsistently across assessment waves, people with anxiety and/or depressive disorders had lower sports participation and general physical activity compared to healthy controls. Greater anxiety or depressive symptoms were associated with lower activity according to all three indicators. Over time, a diagnosis or greater symptom severity at one assessment was associated with poorer sports participation and general physical activity 2 years later. In the opposite direction, only low sports participation was associated with greater symptom severity and increased odds of disorder onset 2 years later. Stronger effects were observed for chronicity, with lower activity according to all indicators increasing the odds of disorder chronicity after 2 years.ConclusionsOver time, there seems to a mutually reinforcing, bidirectional relationship between psychopathology and lower physical activity, particularly low sports participation. People with anxiety are as adversely affected as those with depression.
A pilot randomized controlled trial of time-intensive cognitive–behaviour therapy for postpartum obsessive–compulsive disorder: effects on maternal symptoms, mother–infant interactions and attachment
Authors: Challacombe F. L. , Salkovskis P. M. , Woolgar M. , Wilkinson E. L. , Read J. , Acheson R. 
Published: January 2017

BackgroundThere is increasing recognition that perinatal anxiety disorders are both common and potentially serious for mother and child. Obsessive–compulsive disorder (OCD) can be triggered or exacerbated in the postpartum period, with mothers reporting significant effects on parenting tasks. However, there is little evidence concerning their effective treatment or the impact of successful treatment on parenting.MethodA total of 34 mothers with OCD and a baby of 6 months old were randomized into either time-intensive cognitive–behaviour therapy (iCBT) or treatment as usual (TAU). iCBT took place after randomization at 6 months postpartum and was completed by 9 months. Maternal symptomatology, sensitivity in mother–infant interactions and parenting were assessed at baseline and reassessed at 12 months postpartum. At 12 months attachment was also assessed using Ainsworth's Strange Situation Procedure. A healthy control group of mothers and infants (n = 37) underwent the same assessments as a benchmark.ResultsiCBT was successful in ameliorating maternal symptoms of OCD (controlled effect size = 1.31–1.90). However, mother–infant interactions were unchanged by treatment and remained less sensitive in both OCD groups than a healthy control group. The distribution of attachment categories was similar across both clinical groups and healthy controls with approximately 72% classified as secure in each group.ConclusionsiCBT is an effective intervention for postpartum OCD. Sensitive parenting interactions are affected by the presence of postpartum OCD and this is not improved by successful treatment of OCD symptoms. However, the overall attachment bond appears to be unaffected. Longitudinal studies are needed to explore the impact of postpartum OCD as the child develops.
EDUCATING THE NATION: II. UNIVERSITIES
Authors: Mandler Peter 
Published: January 2017

ABSTRACTThis paper continues the argument made in ‘Educating the Nation: I. Schools’, that democratic demand for ever widening access to education was the principal driver for expansion in the second half of the twentieth century. Demand for higher education was not as universalistic or egalitarian as demand for secondary schooling; nevertheless, it was pressing, especially from the late 1950s, and ultimately irresistible, enshrined in the ‘Robbins principle’ that higher education should be available to all qualified by ability and attainment. The paper tracks the fortunes of the Robbins principle from an initial period of rapid growth, through a mysterious period of sagging demand in the 1970s and 1980s, to the resumption of very rapid growth from the late 1980s. It remains the guiding light of higher-education policy today, though in very altered circumstances where the price is paid ultimately more by beneficiaries than from the public purse.
The role of arousal in predictive coding
Authors: Ferreira-Santos Fernando 
Published: January 2017

AbstractWithin a predictive coding approach, the arousal/norepinephrine effects described by the GANE (glutamate amplifies noradrenergic effects) model seem to modulate the precision attributed to prediction errors, favoring the selective updating of predictive models with larger prediction errors. However, to explain how arousal effects are triggered, it is likely that different kinds of prediction errors (including interoceptive/affective) need to be considered.
Adaptive memory systems for remembering the salient and the seemingly mundane
Authors: Ritchey Maureen , Murty Vishnu P. , Dunsmoor Joseph E. 
Published: January 2017

AbstractIn an adaptive memory system, events should be prioritized in memory based on their own significance, as well as the significance of preceding or following events. Here we argue that tag-and-capture models complement the GANE (glutamate amplifies noradrenergic effects) model by describing a mechanism that supports the transfer of memory benefits from one event to the next.
Attention alters predictive processing
Authors: Clark Andy 
Published: January 2017

AbstractFirestone & Scholl (F&S) bracket many attentional effects as “peripheral,” altering the inputs to a cognitive process without altering the processing itself. By way of contrast, I highlight an emerging class of neurocomputational models that imply profound, pervasive, nonperipheral influences of attention on perception. This transforms the landscape for empirical debates concerning possible top-down effects on perception.
Gaining knowledge mediates changes in perception (without differences in attention): A case for perceptual learning
Authors: Emberson Lauren L. 
Published: January 2017

AbstractFirestone & Scholl (F&S) assert that perceptual learning is not a top-down effect, because experience-mediated changes arise from familiarity with the features of the object through simple repetition and not knowledge about the environment. Emberson and Amso (2012) provide a clear example of perceptual learning that bypasses the authors' “pitfalls” and in which knowledge, not repeated experience, results in changes in perception.
Oh the irony: Perceptual stability is important for action
Authors: Durgin Frank H. 
Published: January 2017

AbstractI review experiments in which drinking a sugarless drink causes some participants who have low blood sugar from fasting to give lower slant estimates. Ironically, this only occurs to the extent that they believe that they have received sugar and that the sugar was meant to make the hill look shallower; those who received sugar showed no similar effect. These findings support the hypothesis that low blood sugar causes greater participant cooperation – which, in combination with other experimental details, can lead participants to make judgments that can either seem to support the effort hypothesis or contradict it. I also emphasize the importance of perceptual stability in the perception of spatial layout.
Crossmodal processing and sensory substitution: Is “seeing” with sound and touch a form of perception or cognition?
Authors: Esenkaya Tayfun , Proulx Michael J. 
Published: January 2017

AbstractThe brain has evolved in this multisensory context to perceive the world in an integrated fashion. Although there are good reasons to be skeptical of the influence of cognition on perception, here we argue that the study of sensory substitution devices might reveal that perception and cognition are not necessarily distinct, but rather continuous aspects of our information processing capacities.
Challenging Assumptions: What Do We Need to Address in Our Disaster Risk Reduction Efforts?
Authors: Codreanu Tudor A. , Ngo Hanh , Robertson Andrew , Celenza Antonio 
Published: January 2017

AbstractIntroductionSpecific knowledge and skills are required, especially in the first 72 hours post-disaster, to bridge the time gap until essential services are restored and Emergency Medical Services (EMS) can focus on individuals’ needs. This study explores disaster knowledge and preparedness in the first 72 hours as a function of the individual’s engagement in discussions about disasters, and several other factors (both at personal and community/country level), as well as the entities/organizations perceived by the individual as being responsible for disaster risk reduction (DRR) education.MethodsA prospective, cross-sectional survey of 3,829 final-year high-school students was conducted in nine countries with different levels of disaster risk and economic development. Regression analyses examined the relationship between a 72-hour disaster preparedness composite outcome (ability to make water safe for drinking, knowledge of water potability, home evacuation skill, and improvising a safe room) and a series of independent predictors.ResultsRespondents from countries with lower economic development were significantly better prepared for the first 72 hours post-disaster than those from developed countries (OR=767.45; CI=13.75-48,822.94;P=.001). While several independent predictors showed a significant main effect, combined disaster risk education (DRE) efforts, as a partnership between school and local government, had the best predictive value (OR=3.52; CI=1.48-8.41;P=.005).ConclusionsDisaster preparedness in final-year high-school students is significantly better in developing countries. Further improvement requires a convergent effort in aligning the most effective educational policies and actions to best address the individual’s and the community needs.CodreanuTA,NgoH,RobertsonA,CelenzaA.Challenging assumptions: what do we need to address in our disaster risk reduction efforts?Prehosp Disaster Med.2017;32(2):134–147.
Identifying domains of quality of life in children with cancer undergoing palliative care: A qualitative study with professionals
Authors: Avoine-Blondin Josianne , Parent Véronique , Lahaye Magali , Humbert Nago , Duval Michel , Sultan Serge 
Published: January 2017

ABSTRACTObjective:The goal of pediatric palliative care (PPC) is to maintain the quality of life (QoL) of children whose lives are threatened. However, there are sparse scientific data on the domains of QoL in this particular context, and no measurement strategies are available. The present study aims to describe the domains of QoL in the context of PPC in oncology, according to the perceptions of professional caregivers.Method:Semistructured interviews were conducted with a random sample of 20 professional caregivers from the Division of Hematology/Oncology at Le Centre Hospitalier Universitaire Sainte-Justine (Montréal, Canada). The caregivers were asked about their perceptions about the QoL of the children they have cared for in this context. The data were analyzed using inductive thematic content analysis.Results:The analysis allowed us to identify seven domains of QoL: “physical comfort,” “alleviation of psychological suffering,” “fun and the present moment,” “sense of control,” “feeling valued and appreciated,” “feeling that life goes on,” and “meaningful social relationships.”Significance of Results:Caregivers recount the regard that should be accorded to maintaining well-being and a sense of fun, as well as fostering the child's abilities, taking account of the progression of the disease, and to fulfilling his or her needs, especially social ones. Our results also demonstrate that all domains were positively referred to by professional caregivers. The data from our study will lead to better assessment of QoL according to the trajectory of a child with advanced cancer while undergoing PPC.
Archaean zircons in Miocene oceanic hotspot rocks establish ancient continental crust beneath Mauritius
Authors: Ashwal Lewis D. , Wiedenbeck Michael , Torsvik Trond H. 
Published: January 2017

AbstractA fragment of continental crust has been postulated to underlie the young plume-related lavas of the Indian Ocean island of Mauritius based on the recovery of Proterozoic zircons from basaltic beach sands. Here we document the first U–Pb zircon ages recovered directly from 5.7 Ma Mauritian trachytic rocks. We identified concordant Archaean xenocrystic zircons ranging in age between 2.5 and 3.0 Ga within a trachyte plug that crosscuts Older Series plume-related basalts of Mauritius. Our results demonstrate the existence of ancient continental crust beneath Mauritius; based on the entire spectrum of U–Pb ages for old Mauritian zircons, we demonstrate that this ancient crust is of central-east Madagascar affinity, which is presently located ∼700 km west of Mauritius. This makes possible a detailed reconstruction of Mauritius and other Mauritian continental fragments, which once formed part of the ancient nucleus of Madagascar and southern India.
Ionic thermoelectric gating organic transistors
Authors: Zhao Dan , Fabiano Simone , Berggren Magnus , Crispin Xavier 
Published: January 2017

AbstractTemperature is one of the most important environmental stimuli to record and amplify. While traditional thermoelectric materials are attractive for temperature/heat flow sensing applications, their sensitivity is limited by their low Seebeck coefficient (∼100 μV K−1). Here we take advantage of the large ionic thermoelectric Seebeck coefficient found in polymer electrolytes (∼10,000 μV K−1) to introduce the concept of ionic thermoelectric gating a low-voltage organic transistor. The temperature sensing amplification of such ionic thermoelectric-gated devices is thousands of times superior to that of a single thermoelectric leg in traditional thermopiles. This suggests that ionic thermoelectric sensors offer a way to go beyond the limitations of traditional thermopiles and pyroelectric detectors. These findings pave the way for new infrared-gated electronic circuits with potential applications in photonics, thermography and electronic-skins.
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
Authors: Hoffmann Thomas J. , Passarelli Michael N. , Graff Rebecca E. , Emami Nima C. , Sakoda Lori C. , Jorgenson Eric , Habel Laurel A. , Shan Jun , Ranatunga Dilrini K. , Quesenberry Charles P. , Chao Chun R. , Ghai Nirupa R. , Aaronson David , Presti Joseph , Nordström Tobias , Wang Zhaoming , Berndt Sonja I. , Chanock Stephen J. , Mosley Jonathan D. , Klein Robert J. , Middha Mridu , Lilja Hans , Melander Olle , Kvale Mark N. , Kwok Pui-Yan , Schaefer Catherine , Risch Neil , Van Den Eeden Stephen K. , Witte John S. 
Published: January 2017

AbstractProstate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa—such as genetics—can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (P<5 × 10−8) single-nucleotide polymorphisms (SNPs): 19 novel, 15 previously identified for PSA (14 of which were also PCa-associated), and 6 previously identified for PCa only. Further analysis incorporating PCa cases suggests that at least half of the 40 SNPs are PSA-associated independent of PCa. The 40 SNPs explain 9.5% of PSA variation in non-Hispanic whites, and the remaining GWAS SNPs explain an additional 31.7%; this percentage is higher in younger men, supporting the genetic basis of PSA levels. These findings provide important information about genetic markers for PSA that may improve PCa screening, thereby reducing over-diagnosis and over-treatment.
Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs
Authors: Osmanbeyoglu Hatice U. , Toska Eneda , Chan Carmen , Baselga José , Leslie Christina S. 
Published: January 2017

AbstractPancancer studies have identified many genes that are frequently somatically altered across multiple tumour types, suggesting that pathway-targeted therapies can be deployed across diverse cancers. However, the same ‘actionable mutation’ impacts distinct context-specific gene regulatory programs and signalling networks—and interacts with different genetic backgrounds of co-occurring alterations—in different cancers. Here we apply a computational strategy for integrating parallel (phospho)proteomic and mRNA sequencing data across 12 TCGA tumour data sets to interpret the context-specific impact of somatic alterations in terms of functional signatures such as (phospho)protein and transcription factor (TF) activities. Our analysis predicts distinct dysregulated transcriptional regulators downstream of somatic alterations in different cancers, and we validate the context-specific differential activity of TFs associated to mutant PIK3CA in isogenic cancer cell line models. These results have implications for the pancancer use of targeted drugs and potentially for the design of combination therapies.
Graphene-based mid-infrared room-temperature pyroelectric bolometers with ultrahigh temperature coefficient of resistance
Authors: Sassi U. , Parret R. , Nanot S. , Bruna M. , Borini S. , De Fazio D. , Zhao Z. , Lidorikis E. , Koppens F.H.L. , Ferrari A. C. , Colli A. 
Published: January 2017

AbstractThere is a growing number of applications demanding highly sensitive photodetectors in the mid-infrared. Thermal photodetectors, such as bolometers, have emerged as the technology of choice, because they do not need cooling. The performance of a bolometer is linked to its temperature coefficient of resistance (TCR, ∼2–4% K−1 for state-of-the-art materials). Graphene is ideally suited for optoelectronic applications, with a variety of reported photodetectors ranging from visible to THz frequencies. For the mid-infrared, graphene-based detectors with TCRs ∼4–11% K−1 have been demonstrated. Here we present an uncooled, mid-infrared photodetector, where the pyroelectric response of a LiNbO3 crystal is transduced with high gain (up to 200) into resistivity modulation for graphene. This is achieved by fabricating a floating metallic structure that concentrates the pyroelectric charge on the top-gate capacitor of the graphene channel, leading to TCRs up to 900% K−1, and the ability to resolve temperature variations down to 15 μK.
Time-resolved monitoring of biofouling development on a flat sheet membrane using optical coherence tomography
Authors: Fortunato Luca , Jeong Sanghyun , Leiknes TorOve 
Published: January 2017

AbstractBiofouling on a membrane leads to significant performance decrease in filtration processes. In this study, an optical coherence tomography (OCT) was used to perform a time-resolved analysis of dynamic biofouling development on a submerged membrane under continuous operation. A real-time change in the biofouling morphology was calculated through the image analysis of OCT scans. Three videos were generated through the acquisition of serial static images. This is the first study that displays the dynamic biofouling formation process as a video. The acquisition of OCT cross-sectional scans of the biofouling allowed to evaluate the time-lapsed evolution for three different time periods (early stage, double layers and long-term). Firstly, at the early filtration stage, membrane coverage and average biofouling layer thickness were found to be linearly correlated with the permeate flux pattern. Secondly, after 3 d of operation, an anomalous morphology was observed, constituted by a double-layered biofouling structure: denser on the bottom and looser on the top. In a long-term operation, the biofouling structure underwent a dynamic evolution over time, resulting in a multi-layered structure. The biofouling formation information was closely associated with filtration performance (i.e. flux) indicating the suitability of OCT as real-time and in-situ biofouling monitoring technique.
Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans
Authors: Rojo Romanos Teresa , Petersen Jakob Gramstrup , Pocock Roger 
Published: January 2017

AbstractMonitoring of neuronal activity within circuits facilitates integrated responses and rapid changes in behavior. We have identified a system in Caenorhabditis elegans where neuropeptide expression is dependent on the ability of the BAG neurons to sense carbon dioxide. In C. elegans, CO2 sensing is predominantly coordinated by the BAG-expressed receptor-type guanylate cyclase GCY-9. GCY-9 binding to CO2 causes accumulation of cyclic GMP and opening of the cGMP-gated TAX-2/TAX-4 cation channels; provoking an integrated downstream cascade that enables C. elegans to avoid high CO2. Here we show that cGMP regulation by GCY-9 and the PDE-1 phosphodiesterase controls BAG expression of a FMRFamide-related neuropeptide FLP-19 reporter (flp-19::GFP). This regulation is specific for CO2-sensing function of the BAG neurons, as loss of oxygen sensing function does not affect flp-19::GFP expression. We also found that expression of flp-19::GFP is controlled in parallel to GCY-9 by the activity-dependent transcription factor CREB (CRH-1) and the cAMP-dependent protein kinase (KIN-2) signaling pathway. We therefore show that two parallel pathways regulate neuropeptide gene expression in the BAG sensory neurons: the ability to sense changes in carbon dioxide and CREB transcription factor. Such regulation may be required in particular environmental conditions to enable sophisticated behavioral decisions to be performed.