bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64
Authors: Gafarov V. V. , Gromova E. A. , Gagulin I. V. , Maksimov V. N. , Gafarova A. V. 
Published: October 2024

Aim. To study the possible relationship between personal anxiety and polymorphic variants of genes associated with eating disorders (rs17782313 MC4R, rs1800497 DRD2, rs9939609 FTO) in women aged 45-64 in Novosibirsk.Material and methods. A random representative sample of women aged 45-64 years (n=1074, mean age, 54,27±0,2 years) was examined in 2003-2005 at the Research Institute of Internal and Preventive Medicine, a branch of the Institute of Cytology and Genetics, within the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) project. Personal anxiety was assessed using the Spielberger self-assessment questionnaire included in the protocol of the Multinational Monitoring of Trends and Determinants of Cardiovascular Disease — Optional Psychosocial Study (MONICA-MOPSY), tested at screenings of the World Health Organization (WHO) MONICA program in 1983-1995. The sample for the HAPIEE program was formed at the program data processing center in Prague for each of the collaborating centers in such a way that each respondent was random. From the sample, every second woman (n=537) was selected for genotyping of the FTO rs9939609 variant (n=384); every third woman (n=358) — for genotyping the MC4R rs17782313 (n=279) and DRD2 rs1800497 variants (n=327). Genotyping was performed in the laboratory of molecular genetic studies by the polymerase chain reaction with the analysis of restriction fragment length polymorphism.Results. Among women aged 45-64, anxiety was detected in 58,3%, and in 15,9% of women the anxiety level was high. The homozygous genotype C/C rs17782313 of the MC4R gene was more common among women with high anxiety levels (17,5%) than among women with low and moderate anxiety levels (1,8 and 0,8%, respectively; p=0,001). There were no significant differences in the detection rate of the rs1800497 genotypes of the DRD2 gene among women with different levels of anxiety (p>0,05). The frequency of the A/A rs9939609 genotype of the FTO gene was highest among women with high anxiety levels — 29,5%, compared to participants with low and moderate anxiety levels (15 and 15,3%, respectively; p=0,048). The probability of anxiety among carriers of the C/C+C/T genotypes of the MC4R gene was 1,29 times higher than among carriers of the T/T genotype (p=0,001). Among carriers of the A/A rs9939609 genotype of the FTO gene, the anxiety probability was 2,34 times higher than among carriers of the A/T+T/T genotypes (p=0,008).Conclusion. The association between anxiety and genes of eating disorders dictates the need for diagnosis and subsequent treatment of anxiety and its associated consequences.
Panic attack semiology in right temporal lobe epilepsy
Authors: Sazgar Mona , Carlen Peter L. , Wennberg Richard 
Published: October 2024

Background:
Panic attack semiology as a manifestation of epileptic seizures may lead to difficulties and delay in diagnosis. We present a case series to demonstrate the association of ictal panic and anxiety symptoms with partial seizures lateralized to the right temporal lobe.

Methods:
From 112 consecutive patients with intractable temporal lobe epilepsy (59 right, 53 left) referred for video‐EEG monitoring, five patients were identified whose seizures had been diagnosed as panic attacks in the past. Their ictal symptomatology included feelings of panic and impending doom, hyperventilation, palpitation, diaphoresis, shortness of breath and generalized paresthesiae. Ictal panic was not identified in 72 patients with extratemporal epilepsy investigated during the same period.

Results:
EEG documented a right anterior to mid‐temporal focus in all five patients. Brain MRI or pathology showed right mesial temporal sclerosis in four and a right temporal ganglioglioma in one. Ictal tachycardia was documented with EEG‐EKG recording in the latter patient, prior to right anterior temporal lobectomy and amygdalohippocampectomy. Reinvestigation of this patient five years later for recurrent seizures, no longer associated with panic symptomatology, showed right temporal ictal onsets with seizure spread to the left temporal lobe, now associated with ictal bradycardia.

Conclusions:
Our case series provides further evidence to support a relationship between panic attack symptomatology and ictal involvement of the right mesial temporal region [Published with video sequences].
Prevalence of allergens in children: a single centre experience
Authors: Varma Manisha G. , Reddy Aparna P. , Subramanya Latha M. 
Published: October 2024

Background: The exact epidemiological data on the allergic disorders, food sensitization and probable food allergy in Indian children is lacking. In this study, as an attempt to address the paucity of data in Indian children, the clinical profile of allergies and common allergens among children <18 years was described by identifying the allergens by skin prick test (SPT) and IgE immunocap. This may help the clinician to treat allergies better and administer appropriate immunotherapy.
Methods: This prospective observational study aimed to estimate the prevalence of allergens in children with symptoms of allergy. Identification of specific allergens using Skin prick test (SPT) and IgE based tests, assessing various allergies and understand the parent’s insight towards allergy were the objectives.
Results: In 108 children, bronchial asthma (62.9%), allergic rhinitis (53.7%), atopic dermatitis (9.2%), allergic conjunctivitis (5.5%), urticaria (5.5%), and food allergy (1.85%) were the specific allergies.SPT (n=101) was positive in 71.3% and IgE Immunocap (n=07) in two. Children were most sensitive to aeroallergens (House dust mite 75.3%, fungus/mould 35%, pollen 32.4%) than food allergens (2.5%). Among children with allergic rhinitis and bronchial asthma (n=28), 78.5% showed positive SPT to Dermatophagoides farinae (68.1%), Dermatophagoides pteronyssinus (63.6%). Among parents, 26.85% thought the symptoms were due to allergy but 79.31% children were positive to either SPT/IgE test. Remaining (73.15%) who thought otherwise, 74.68% of their children showed positive allergy tests.
Conclusions: Aeroallergens are more common in children with allergy. Dust mite is the commonest allergen. Only few parents rightly thought that their children had allergy.
Chronic medical conditions and health care utilization in Indian marathon athletes: a cross-sectional observational study
Authors: Oak Medha , Oak Ajit S. , Oak Bageshree 
Published: October 2024

Background: The purpose of this study was to investigate the prevalence of chronic medical conditions and healthcare utilization among Indian marathon athletes through a digital survey.
Methods: This was a cross-sectional, observational study that employed a questionnaire-based digital survey of Indian marathon athletes. The survey collected data on participants' demographics, training history, chronic medical conditions, and healthcare utilization. Descriptive statistics were used to analyze the data.
Results: A total of 224 marathon athletes participated in the survey from April 2023 to June 2023. The largest segment of respondents (40.6%) fell within the age bracket of over 50 years, and 82.3% were male. Among the participants, 84.9% were married, and 77% were employed in the private sector. About 56% were involved in some sports activity prior and 90% opined they follow a healthy lifestyle. On comorbidities, hypertension was most prevalent (23.2%) followed by diabetes (13%), hyperlipidemia (9.3%), and asthma (2.2%). About 95% do not take any pain medications during a marathon and 29 % were not aware of the precautions to be taken for running a marathon with chronic medical conditions. Around 69.6% do not consult a physician to get advice and approval before a marathon and 73.1% mentioned that they do not take regular medication for chronic medical conditions like diabetes and hypertension
Conclusion: Indian marathon athletes have a significant prevalence of chronic medical conditions, with hypertension, asthma, and diabetes being the most common. A substantial proportion of athletes sustain injuries during training and competition, leading to healthcare utilization, particularly for physical therapy. These findings highlight the importance of comprehensive pre-participation medical evaluations and targeted injury prevention strategies for this population.
Ewaluacja środowiskowa w relacjach z dostawcami
Authors: Sosnowski Piotr Cezary 
Published: October 2024

Niniejsza monografia stanowi odpowiedź na rosnące znaczenie ograniczania negatywnego oddziaływania na środowisko w łańcuchu dostaw.
W opracowaniu zostały omówione m.in. takie zagadnienia, jak:
– istota oceny i ewaluacji dostawców, w tym przede wszystkim ewaluacji środowiskowej,
– charakterystyka łańcucha dostaw oraz zarządzania nim,
– etapy zarządzania procesem zakupu oraz budowania relacji z dostawcami,
– propozycja nowego podejścia do ewaluacji dostawców.
Publikacja jest skierowana do:
– menadżerów i specjalistów zajmujących się oceną i ewaluacją dostawców, badaczy związanych z obszarami zarządzania zakupami, logistyki, zarządzania łańcuchem dostaw oraz zarządzania środowiskowego,
– studentów kierunków ekonomicznych, logistyki, zarządzania i ochrony środowiska.
Monografia została opracowana na podstawie rozprawy wyróżnionej jako najlepsza praca doktorska z zakresu logistyki w I Ogólnopolskim Konkursie na Najlepsze Prace Dyplomowe z Zakresu Logistyki, organizowanym przez Uniwersytet Szczeciński pod patronatem Enea Operator sp. z o.o.
Universal Forward Training and Structure-free Learning
Authors: Cai Gang , Wu Lingyan 
Published: October 2024

Abstract

The research of high-dimensional nonlinear systems has broad theoretical and engineering application prospects. As the structure complexity and depth of AI neural networks increase, there is an urgent need to work out forward training methods to deal with gradient vanishing, large storage, structure and deep constraints. Using the hypotheses and treatments of local linearization(LL) and isomorphism comparability(IC), here we present a novel systematic theory LL-IC and a universal forward training method LIFT for any stable and smooth parametric system even with a black-box structure. Experiments on DNN, SaNN, SaKAN, RAN, MLP, and IIR filter, proved the feasibility, effectiveness, and applicability. LIFT is a structure-free learning and universal complete forward training method, that has universality, simplicity, equality, and freedom features. It has important engineering significance in AI networks because of its potentially diverse designs like security isolation, energy-saving structure, distributed architecture, or parallel computation. It’s also attractive in math or other engineering fields.
Evaluating the Reading Performance of Chinese Glaucoma Patients by Using the C-Read Device
Authors: Suo Lingge , Cheng Tian , Zhang Weijia , Zhang Junyun , Wang Yi , Zhou Ji-chao , You Debo , Zhang Chun 
Published: October 2024

Abstract

Purpose: The C-Read is a type of Chinese reading-ability test chart, with its supporting electronic portable device that assesses Chinese reading ability. This study evaluates the reading performance of Chinese glaucoma patients using C-Read device.
Methods: A total of 163 glaucoma patients (326 eyes), 56 age-matched healthy controls (112 eyes) and 220 young healthy controls (440 eyes) were recruited. C-Read measured reading acuity (RA), maximum reading speed (MRS), and critical print size (CPS) in simplified Chinese. Glaucoma patients were classified by the Aulhorn and Karmeyer classification (A&K) and visual field defect location (superior, inferior, or annular).
Results: Glaucoma patients showed significantly lower RA, MRS, and CPS compared to age-matched (RA: P < 0.001; MRS: P = 0.016; CPS: P=0.001) and young healthy controls (all P < 0.001). Reading performance declined with increased glaucoma severity and was significantly impaired even in mild cases (all P < 0.001). Annular visual field defects resulted in the lowest reading abilities (all P < 0.001). VFQ-25 scores correlated with age, spherical equivalent (SE), and A&K classification (all P < 0.001).
Conclusions: C-Read is an effective method for evaluating reading ability in Chinese glaucoma patients. Severity, visual field defect location, age, and refractive status impact reading ability and QoL. Early-stage glaucoma patients experience reading impairment, particularly with central visual field involvement. Reading ability correlates with QoL, reflecting glaucoma's impact on visual function and daily activities. The test's high sensitivity suggests its potential as an economical early screening tool for glaucoma.
Veratridine, a plant-derived alkaloid, suppresses the hyperactive Rictor-mTORC2 pathway: a new targeted therapy for primary and metastatic colorectal cancer
Authors: Eikanger Morgan M. , Sane Sanam , Schraufnagel Kate S. , Slunecka John L. , Potts Rashaun A. , Freeling Jessica , Sereda Grigoriy , Rasulev Bakhtiyor , Brockstein Reed L. , Emon M A Bashar , Saif M Taher A. , Rezvani Khosrow 
Published: October 2024

Abstract

Despite considerable advances to improve colorectal cancer (CRC) survival over the last decade, therapeutic challenges remain due to the rapid metastatic dissemination of primary tumors and screening limitations. Meanwhile, the rise of CRC in younger adults (Early-onset CRC), commonly diagnosed with a metastatic form of the disease, shows the pressing need to develop more effective targeted therapies to decrease the high mortality rates associated with metastatic disease. Hyperactivation of the Rictor-mTORC2-AKT signaling pathway drives key metastatic players in diverse malignant tumors, including early- and late-onset colorectal cancer. Selective mTORC2 inhibitors are becoming a potential treatment strategy for CRC due to the therapeutic limitations of mTORC1 inhibitors. Veratridine (VTD), a lipid-soluble alkaloid extracted from Liliaceae plants, can transcriptionally increase UBXN2A, which induces 26S proteasomal degradation of the Rictor protein, a key member in the mTORC2 complex. Destabilization of Rictor protein by VTD decreases Akt phosphorylation on Ser473, which is responsible for metastatic signaling downstream of the mTORC2 pathway in diverse malignant tumors. VTD decreases the population of metastatic colon cancer stem cells and functions as an angiogenesis inhibitor. VTD effectively reduces the spheroid growth rate and restricts cell migration. Live cell migration and invasion assays alongside biomechanical-force-based experiments revealed that VTD suppresses colon cancer cell invasiveness and the ensuing risk of tumor metastasis. A CRC mouse model that mimics the natural stages of human sporadic CRC revealed that VTD treatment significantly decreases tumor growth in a UBXN2A-dependent manner. This study showed a novel mechanistic connection between a ubiquitin-like protein and mTORC2-dependent migration and invasion in CRC tumors. This study revealed the therapeutic benefit of selective inhibition of Rictor in CRC, particularly in tumors with a hyperactive Rictor-mTORC2 signaling pathway. Finally, this study opened a new platform for repurposing VTD, a supplemental anti-hypertension molecule, into an effective targeted therapy in CRC tumors.
Assessment of the Correlation between Nano and Micro Analysis Studies and the Sustainable Development Goals
Authors: Nour Ahmed A. , Saudy Maram M. , Abou-Zeid Mohamed N. 
Published: October 2024

Abstract

The significance of Nano and Micro analysis becomes more evident when their contributions to the Sustainable Development Goals (SDGs) is manifested. The main work objective is to establish a robust assessment and correlation between the Nano/Micro analysis and the different SDGs. To achieve this objective, first, a comprehensive literature review was conducted to examine how Nano and Micro analysis studies align with the 17 SDGs by mapping various Nano and Micro analysis techniques, from a wide range of research to the 17 SDGs. Then, a circular diagram to provide an engaging graphical representation of the mapping results was developed.
Second, a practical statistical analysis was conducted on an eighteen-month data set of recorded entries from a renowned Nano and Microtechnology Research Center in Cairo to seek an evidence of potential contribution of Nano and Micro analysis studies and tools to the 17 SDGs. The collected data were categorized and thoroughly mapped to the 17 SDGs. Findings of this research proved a good correlation between the different studied Nano/Micro analysis techniques and the SDGs. The SDGs of the highest correlation were: SDG06 clear water sanitation, SDG09 industry, innovation and infrastructure SDG12 responsible consumption, and SDG17 partnership for the goals. The most contributing fields of study in a descending order were healthcare and medicine, material science, environmental sustainability, energy, food and agriculture, electronics, and construction and civil engineering. Finally, a set of recommendations for future practical work, as well as recommendations to more profoundly promote the progress towards sustainability were provided.
Diversity and Abundance of Agriculturally Important Insects and Pests in the Bitter Gourd Ecosystem at Selected Locations in Coimbatore, Tamil Nadu, India
Authors: CHIRASANI NAGA RANI , Ragumoorthi K.N. , Sake Manideep , B Tulasi , R Aswini , Talapala Sai Kumar 
Published: October 2024

Abstract

Bitter gourd holds a prominent position among vegetables due to its high nutritional and medicinal value. However, various factors contribute to its lower production, including attacks by several pests such as the red pumpkin beetle, fruit fly, jassids, aphids, and whitefly, affecting different stages (seedling, vegetative, and reproductive) and parts (stem, leaves, flowers, and fruits) of the plant. From February to July 2023, a total of 12,481 individual arthropods belonging to 80 species from 45 families, 74 genera, and 10 orders, across two classes (Insecta and Arachnida), were documented in the bitter gourd ecosystem. The order Coleoptera was the most diverse, with 22 species from eight families, followed by Hymenoptera with 15 species from eight families, Lepidoptera (10 species, four families), Hemiptera (nine species, seven families), Diptera (eight species, eight families), Odonata (five species, two families), Orthoptera (three species, two families), Mantodea (two species, one family), and Thysanoptera (one species, one family). Additionally, five spider species from five genera and four families were recorded. Among the arthropods, predators represented the largest group with 34 species, followed by pests (22 species), pollinators (19 species), parasitoids (two species), and tourists (three species). The highest species diversity and richness were recorded in Narasipuram, with a Shannon-Weiner diversity index of 3.268, followed by TNAU Orchard (3.182), and Thondamuthur (2.914). Pollachi exhibited the lowest diversity (2.681).
1-year Real-World Outcomes of Faricimab in Previously Treated Neovascular Age-Related Macular Degeneration
Authors: Janmohamed Imran , Mushtaq Adeel , Kabbani Jamil , Harrow Simeon , Nadarajasundaram Aaruran , Ata Anibe , Monye Henrietta , Jarrar Zakariya , Hannan Shabeeba , Membrey Luke 
Published: October 2024

Abstract

Background and Objectives
Faricimab, a bispecific antibody targeting VEGF-A and angiopoietin-2, has shown promise in treating neovascular age-related macular degeneration (nAMD). This study evaluates one-year outcomes of faricimab in treatment-experienced nAMD patients.
Methods
This single-centre retrospective cohort study included patients previously treated for nAMD who switched to faricimab between November 2022 and March 2024. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and treatment intervals were assessed at baseline, 6, and 12 months.
Results
184 patients (215 eyes) were included. Patients had received a median of 18 (interquartile range [IQR] 10-28.5) anti-VEGF injections per eye over an average of 5.02 ± 11.82 years before switch. An average of 8.63 ± 2.2 faricimab injections were administered per eye over an average follow-up of 12.19 ± 2.70 months. Median BCVA decreased from 70 ETDRS letters (IQR 55–76) at baseline to 62 (IQR 47–76) at 12 months (p = 0.0038). Median CMT improved from 259.5 µm (IQR 223-299.75) at baseline to 232 µm (202.0-272.5) at 12 months (p < 0.0001). At the last follow-up, 40.2% of eyes were dry on OCT. The median dosing interval doubled from 4 weeks (IQR 4–4) to 8 weeks (IQR 6–10) with faricimab (p < 0.0001). 47.4% and 16.3% of eyes achieved treatment intervals of ≥ 8–12 weeks and ≥ 12 weeks, respectively. Three events of uveitis were noted following the loading phase.
Conclusions
This real-world study demonstrates that faricimab maintains vision and achieves significant anatomical improvements in treatment-experienced nAMD patients. The extended treatment intervals could significantly reduce the burden on patients and healthcare resources.
Environmental Impact Assessment of Traditional and Sustainable Garments Washing Approaches for Denim Apparels: A Step toward Cleaner Production and Consumption
Authors: Rahaman Md.Tareque , Hasan Md. Kamrul , Khan Md.Shakib Hossain 
Published: October 2024

Abstract

In today's fashion industry, the sustainability of garment washing processes especially denim washing is unquestionably an important issue. A garment's design and aesthetic appeal have a big impact on how consumers opt to purchase. Denim enthusiasts now have a variety of alternatives, such as eco-denim initiatives, zero water technologies, oxygen and ozone washes, advanced and organic denim, and less harmful fabric dyeing and washing practices. Many of these choices may not be as environmentally friendly as they are advertised to be, though regardless of their marketing commitments. The goal of this research paper is to contrast the three traditional washing methods such as dark, medium, and light washes with their sustainable counterparts. The present research provides a detailed comparison of traditional and sustainable washing methods, highlighting their advantages and drawbacks. While both approaches can produce the about same appearances for the apparels, sustainable washing works out to be more effective, saving at least 25 minutes per wash. Sustainable light washing saves water consumption an additional 3.9 L/Kg garments, while medium and dark washing saves 14.44 L/Kg and 19.4 L/Kg garments. When compared to traditional washes, sustainable washes have reduced consumption of energy and chemical impact scores. Conventional methods of washings (35 for light, 42 for medium, and 49 for dark wash) have more EIM (Environmental Impact Measurement) score in a comparison to sustainable washing (14 for light, 21 for medium, and 23 for dark wash). It also indicates that environmentally friendly and more efficient washing practices are feasible. This provides an excellent illustration of how crucial ethical choices are. An environmental impact score of more than 66, as determined by the EIM software evaluation, is considered to be harmful to the environment whereas 0–33 indicates low effect, and 34–66 indicates medium impact.