bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the appropriateness of prevention and management of venous thromboembolism in Australia: a cross-sectional study
Authors: Hibbert Peter D , Hannaford Natalie A , Hooper Tamara D , Hindmarsh Diane M , Braithwaite Jeffrey , Ramanathan Shanthi A , Wickham Nicholas , Runciman William B 
Published: March 2016

ObjectivesThe prevention and management of venous thromboembolism (VTE) is often at variance with guidelines. The CareTrack Australia (CTA) study reported that appropriate care (in line with evidence-based or consensus-based guidelines) is being provided for VTE at just over half of eligible encounters. The aim of this paper is to present and discuss the detailed CTA findings for VTE as a baseline for compliance with guidelines at a population level.SettingThe setting was 27 hospitals in 2 states of Australia.ParticipantsA sample of participants designed to be representative of the Australian population was recruited. Participants who had been admitted overnight during 2009 and/or 2010 were eligible. Of the 1154 CTA participants, 481(42%) were admitted overnight to hospital at least once, comprising 751 admissions. There were 279 females (58%), and the mean age was 64 years.Primary and secondary outcome measuresThe primary measure was compliance with indicators of appropriate care for VTE. The indicators were extracted from Australian VTE clinical practice guidelines and ratified by experts. Participants’ medical records from 2009 to 2010 were analysed for compliance with 38 VTE indicators.ResultsOf the 35 145 CTA encounters, 1078 (3%) were eligible for scoring against VTE indicators. There were 2–84 eligible encounters per indicator at 27 hospitals. Overall compliance with indicators for VTE was 51%, and ranged from 34% to 64% for aggregated sets of indicators.ConclusionsThe prevention and management of VTE was appropriate for only half of the at-risk patients in our sample; this provides a baseline for tracking progress nationally. There is a need for national and, ideally, international agreement on clinical standards, indicators and tools to guide, document and monitor care for VTE, and for measures to increase their uptake, particularly where deficiencies have been identified.
Ultra-processed foods and added sugars in the US diet: evidence from a nationally representative cross-sectional study
Authors: Martínez Steele Eurídice , Baraldi Larissa Galastri , Louzada Maria Laura da Costa , Moubarac Jean-Claude , Mozaffarian Dariush , Monteiro Carlos Augusto 
Published: March 2016

ObjectivesTo investigate the contribution of ultra-processed foods to the intake of added sugars in the USA. Ultra-processed foods were defined as industrial formulations which, besides salt, sugar, oils and fats, include substances not used in culinary preparations, in particular additives used to imitate sensorial qualities of minimally processed foods and their culinary preparations.DesignCross-sectional study.SettingNational Health and Nutrition Examination Survey 2009–2010.ParticipantsWe evaluated 9317 participants aged 1+ years with at least one 24 h dietary recall.Main outcome measuresAverage dietary content of added sugars and proportion of individuals consuming more than 10% of total energy from added sugars.Data analysisGaussian and Poisson regressions estimated the association between consumption of ultra-processed foods and intake of added sugars. All models incorporated survey sample weights and adjusted for age, sex, race/ethnicity, family income and educational attainment.ResultsUltra-processed foods comprised 57.9% of energy intake, and contributed 89.7% of the energy intake from added sugars. The content of added sugars in ultra-processed foods (21.1% of calories) was eightfold higher than in processed foods (2.4%) and fivefold higher than in unprocessed or minimally processed foods and processed culinary ingredients grouped together (3.7%). Both in unadjusted and adjusted models, each increase of 5 percentage points in proportional energy intake from ultra-processed foods increased the proportional energy intake from added sugars by 1 percentage point. Consumption of added sugars increased linearly across quintiles of ultra-processed food consumption: from 7.5% of total energy in the lowest quintile to 19.5% in the highest. A total of 82.1% of Americans in the highest quintile exceeded the recommended limit of 10% energy from added sugars, compared with 26.4% in the lowest.ConclusionsDecreasing the consumption of ultra-processed foods could be an effective way of reducing the excessive intake of added sugars in the USA.
Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review
Authors: Luo Jing , Jin Di-Er , Yang Guo-Yan , Zhang Ying-Ze , Wang Jian-Ming , Kong Wei-Ping , Tao Qing-Wen 
Published: March 2016

IntroductionTotal glucosides of paeony (TGP) is a natural plant extract, which is widely used in China for treating rheumatoid arthritis (RA). Many relevant randomised controlled trials (RCTs) of TGP for RA are available, but they have not been systematically reviewed. This systematic review aims to examine the effectiveness and safety of TGP in patients with RA.Methods and analysesWe will search for RCTs of TGP in the treatment of RA, performed up until February 2016, in PubMed, Embase, Cochrane Central Register of Controlled Trials, and four Chinese databases (Chinese Biomedical Database, China National Knowledge Infrastructure, Wanfang Database and Chinese Scientific Journal Database). Trial registers and reference lists of retrieved articles will also be searched to identify potential articles. RCTs comparing TGP with placebo, no treatment, or disease-modifying antirheumatic drugs for patients with RA will be retrieved. The primary outcomes will be disease improvement and disease remission. The secondary outcomes will be surrogate outcomes, symptoms, adverse effects, and quality of life. Two reviewers will independently extract data on participants, interventions, comparisons, outcomes, etc. The methodological quality of each included study will be evaluated using the Cochrane risk of bias tool, and the strength of evidence on prespecified outcomes will be assessed in accordance with the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Review Manager 5.3 software will be used for data analyses. Meta-analyses will be performed if the data are sufficiently homogeneous, both statistically and clinically. Possible publication bias will also be checked using funnel plots once the number of included studies is sufficient.Ethics and disseminationEthics approval is not required, as this study will not involve patients. The results of this study will be submitted to a peer-reviewed journal for publication, to inform both clinical practice and further research.Trial registration numberCRD42015026345.
Adverse psychosocial work factors, blood pressure and hypertension incidence: repeated exposure in a 5-year prospective cohort study
Authors: Trudel Xavier , Brisson Chantal , Milot Alain , Masse Benoit , Vézina Michel 
Published: March 2016

BackgroundTwo main theoretical models have been used to assess the impact of psychosocial work factors on blood pressure (BP): the demand–control (DC) model and the effort–reward imbalance (ERI) model. Previous studies have mostly used a single time point exposure to examine this association.ObjectiveTo examine the effect of repeated job strain and ERI exposure on (1) ambulatory BP (ABP) evolution over 5 years and (2) hypertension incidence over 5 years.MethodThe design is a prospective cohort study. The study population was composed of 1394 white-collar workers (568 men and 826 women). They were assessed three times during a 5-year period (years 1, 3 and 5). At each time, psychosocial work factors were measured using validated scales and ABP was measured every 15 min during a working day.ResultsMen who were chronically exposed over 5 years to an active job had a higher cumulative incidence of hypertension (RR=2.05, 95% CI 1.36 to 3.09), compared with never-exposed men. In women, ERI exposure onset was associated with higher increases in systolic ABP (+2.5 mm Hg). No association was found between chronic high-strain exposure and ABP.ConclusionsChronic exposure to active jobs in men led to a higher risk of hypertension and ERI exposure onset in women led to increases in systolic ABP. Results from the present study highlight the need to consider chronic exposure in order to fully capture the deleterious effect of adverse psychosocial work stressors on cardiovascular health.
Soluble B-Cell Maturation Antigen Mediates Tumor-Induced Immune Deficiency in Multiple Myeloma
Authors: Sanchez Eric , Gillespie Abigail , Tang George , Ferros Morgan , Harutyunyan Nika Manik , Vardanyan Suzie , Gottlieb Jillian , Li Mingjie , Wang Cathy S. , Chen Haiming , Berenson James R. 
Published: March 2016

AbstractPurpose: Reduced uninvolved immunoglobulin (Ig) levels are a hallmark of multiple myeloma. We previously showed that B-cell maturation antigen (BCMA) is solubilized and at high levels in multiple myeloma patient serum. We hypothesize that soluble BCMA binds B-cell–activating factor (BAFF) preventing its function to stimulate late B cells, and would result in lower polyclonal antibody levels in these patients.Experimental Design: Mice were dosed with recombinant human BCMA (rhBCMA) and BCMA–BAFF complexes were analyzed in plasma, and its effects on antibody and Ig heavy chain mRNA levels determined. Using flow cytometry, BAFF binding to B cells was examined in the presence of rhBCMA and sera from multiple myeloma patients. In multiple myeloma sera, BCMA–BAFF complex formation and BCMA, IgA, IgG levels, and heavy–light chain isoform pair levels were determined.Results: rhBCMA–BAFF complexes formed in immune-competent and deficient mice. Mice with human multiple myeloma xenografts, which contain plasma hBCMA and hBCMA–BAFF complexes, showed reduced plasma-free BAFF levels. rhBCMA administered to immune competent mice markedly reduced plasma IgA, IgG, and IgM levels and splenic Ig heavy chain mRNA levels. In serum from multiple myeloma patients, BCMA–BAFF complexes were detected and BAFF levels were reduced. Multiple myeloma patient sera containing BCMA prevented binding of BAFF to B cells. There is an inverse correlation between serum BCMA and uninvolved polyclonal Ig level in multiple myeloma patients.Conclusions: Our results show that soluble BCMA sequesters circulating BAFF, thereby preventing it from performing its signaling to stimulate normal B-cell and plasma cell development, resulting in reduced polyclonal antibody levels in multiple myeloma patients. Clin Cancer Res; 22(13); 3383–97. ©2016 AACR.
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma–like and Non–Small Cell Carcinoma–like Subsets
Authors: Rekhtman Natasha , Pietanza Maria C. , Hellmann Matthew D. , Naidoo Jarushka , Arora Arshi , Won Helen , Halpenny Darragh F. , Wang Hangjun , Tian Shaozhou K. , Litvak Anya M. , Paik Paul K. , Drilon Alexander E. , Socci Nicholas , Poirier John T. , Shen Ronglai , Berger Michael F. , Moreira Andre L. , Travis William D. , Rudin Charles M. , Ladanyi Marc 
Published: March 2016

Abstract
Purpose: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a highly aggressive neoplasm, whose biologic relationship to small cell lung carcinoma (SCLC) versus non-SCLC (NSCLC) remains unclear, contributing to uncertainty regarding optimal clinical management. To clarify these relationships, we analyzed genomic alterations in LCNEC compared with other major lung carcinoma types.
Experimental Design: LCNEC (n = 45) tumor/normal pairs underwent targeted next-generation sequencing of 241 cancer genes by Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) platform and comprehensive histologic, immunohistochemical, and clinical analysis. Genomic data were compared with MSK-IMPACT analysis of other lung carcinoma histologies (n = 242).
Results: Commonly altered genes in LCNEC included TP53 (78%), RB1 (38%), STK11 (33%), KEAP1 (31%), and KRAS (22%). Genomic profiles segregated LCNEC into 2 major and 1 minor subsets: SCLC-like (n = 18), characterized by TP53+RB1 co-mutation/loss and other SCLC-type alterations, including MYCL amplification; NSCLC-like (n = 25), characterized by the lack of coaltered TP53+RB1 and nearly universal occurrence of NSCLC-type mutations (STK11, KRAS, and KEAP1); and carcinoid-like (n = 2), characterized by MEN1 mutations and low mutation burden. SCLC-like and NSCLC-like subsets revealed several clinicopathologic differences, including higher proliferative activity in SCLC-like tumors (P &lt; 0.0001) and exclusive adenocarcinoma-type differentiation marker expression in NSCLC-like tumors (P = 0.005). While exhibiting predominant similarity with lung adenocarcinoma, NSCLC-like LCNEC harbored several distinctive genomic alterations, including more frequent mutations in NOTCH family genes (28%), implicated as key regulators of neuroendocrine differentiation.
Conclusions: LCNEC is a biologically heterogeneous group of tumors, comprising distinct subsets with genomic signatures of SCLC, NSCLC (predominantly adenocarcinoma), and rarely, highly proliferative carcinoids. Recognition of these subsets may inform the classification and management of LCNEC patients. Clin Cancer Res; 22(14); 3618–29. ©2016 AACR.
Increased von Willebrand factor, P-selectin and fibrin content in occlusive thrombus resistant to lytic therapy
Authors: Del Blanco Bruno , Ruiz-Meana Marisol , Francisco Jaume , Barrabés José , Figueras Jaume , Bañeras Jordi , Otaegui Imanol , Rojas Angeles , Vilardosa Úrsula , Montaner Joan , García-Dorado David , Sambola Antonia 
Published: March 2016

SummaryTherapeutic fibrinolysis is ineffective in 40 % of ST-segment elevation acute myocardial infarction (STEMI) patients, but understanding of the mechanisms is incomplete. It was our aim to compare the composition of coronary thrombus in lysis-resistant STEMI patients with that of lysis-sensitive patients. Intracoronary thrombi (n=64) were obtained by aspiration in consecutive STEMI patients. Of them, 20 had received fibrinolysis and underwent rescue percutaneous coronary intervention (r-PCI, lysis-resistant patients) and 44 underwent primary PCI (p-PCI). Lysis-sensitivity was determined in vitro by clot permeability measurements and turbidimetric lysis in plasma of 44 patients undergoing p-PCI and 20 healthy donors. Clot-lysis sensitivity was defined as a clot-lysis time not greater than 1 SD over the mean of healthy donors. Coronary thrombus composition in 20 lysis-resistant and in 20 lysissensitive patients was analysed by immunofluorescence with confocal microscopy. Plasma biomarkers (P-selectin, VWF, PAI-1, t-PA, D-dimer, TF pathway markers, plasmin and CD34+) were measured simultaneously on peripheral blood. Lysis-resistant clots had higher levels of fibrin (p=0.02), P-selectin (p=0.03) and VWF (p=0.01) than lysis-sensitive clots. Among thrombi obtained ≤ 6 hours after onset of symptoms, those from lysis-resistant patients showed a higher content in fibrin than those from p-PCI patients (p=0.01). Plasma PAI-1 (p=0.02) and D-dimer levels were significantly higher (p=0.003) in lysis-resistant patients, whereas plasmin levels were lower (p=0.03). Multivariate analysis showed the content of fibrin and VWF within thrombus as predictors of thrombolysis resistance. In conclusion, coronary thrombi in STEMI patients resistant to fibrinolysis are characterised by higher fibrin, P-selectin and VWF content than lysis-sensitive thrombi.
Right Ventricular Volumes and Systolic Function by Cardiac Magnetic Resonance and the Impact of Sex, Age, and Obesity in a Longitudinally Followed Cohort Free of Pulmonary and Cardiovascular Disease
Authors: Foppa Murilo , Arora Garima , Gona Philimon , Ashrafi Arman , Salton Carol J. , Yeon Susan B. , Blease Susan J. , Levy Daniel , O’Donnell Christopher J. , Manning Warren J. , Chuang Michael L. 
Published: March 2016

Background—
Cardiac magnetic resonance is uniquely well suited for noninvasive imaging of the right ventricle. We sought to define normal cardiac magnetic resonance reference values and to identify the main determinants of right ventricular (RV) volumes and systolic function using a modern imaging sequence in a community-dwelling, longitudinally followed cohort free of clinical cardiovascular and pulmonary disease.

Methods and Results—

The Framingham Heart Study Offspring cohort has been followed since 1971. We scanned 1794 Offspring cohort members using steady-state free precession cardiac magnetic resonance and identified a reference group of 1336 adults (64±9 years, 576 men) free of prevalent cardiovascular and pulmonary disease. RV trabeculations and papillary muscles were considered cavity volume. Men had greater RV volumes and cardiac output before and after indexation to body size (all
P
<0.001). Women had higher RV ejection fraction than men (68±6% versus 64±7%;
P
<0.0001). RV volumes and cardiac output decreased with advancing age. There was an increase in raw and height-indexed RV measurements with increasing body mass index, but this trend was weakly inverted after indexation of RV volumes to body surface area. Sex, age, height, body mass index, and heart rate account for most of the variability in RV volumes and function in this community-dwelling population.

Conclusions—
We report sex-specific normative values for RV measurements among principally middle-aged and older adults. RV ejection fraction is greater in women. RV volumes increase with body size, are greater in men, and are smaller in older people. Body surface area seems to be appropriate for indexation of cardiac magnetic resonance–derived RV volumes.
Urban Sprawl Patterns and Processes in Delhi from 1977 to 2014 Based on Remote Sensing and Spatial Metrics Approaches
Authors: Jain Madhavi , Dimri A. P. , Niyogi D. 
Published: March 2016

Abstract
Recent decades have witnessed rapid urbanization and urban population growth resulting in urban sprawl of cities. This paper analyzes the spatiotemporal dynamics of the urbanization process (using remote sensing and spatial metrics) that has occurred in Delhi, the capital city of India, which is divided into nine districts. The urban patterns and processes within the nine administrative districts of the city based on raw satellite data have been taken into consideration. Area, population, patch, edge, and shape metrics along with Pearson’s chi statistics and Shannon’s entropy have been calculated. Three types of urban patterns exist in the city: 1) highly sprawled districts, namely, West, North, North East, and East; 2) medium sprawled districts, namely, North West, South, and South West; and 3) least sprawled districts—Central and New Delhi. Relative entropy, which scales Shannon’s entropy values from 0 to 1, is calculated for the districts and time spans. Its values are 0.80, 0.92, and 0.50 from 1977 to 1993, 1993 to 2006, and 2006 to 2014, respectively, indicating a high degree of urban sprawl. Parametric and nonparametric correlation tests suggest the existence of associations between built-up density and population density, area-weighted mean patch fractal dimension (AWMPFD) and area-weighted mean shape index (AWMSI), compactness index and edge density, normalized compactness index and number of patches, and AWMPFD and built-up density.
The Pacific Decadal Oscillation, Revisited
Authors: Newman Matthew , Alexander Michael A. , Ault Toby R. , Cobb Kim M. , Deser Clara , Di Lorenzo Emanuele , Mantua Nathan J. , Miller Arthur J. , Minobe Shoshiro , Nakamura Hisashi , Schneider Niklas , Vimont Daniel J. , Phillips Adam S. , Scott James D. , Smith Catherine A. 
Published: March 2016

Abstract
The Pacific decadal oscillation (PDO), the dominant year-round pattern of monthly North Pacific sea surface temperature (SST) variability, is an important target of ongoing research within the meteorological and climate dynamics communities and is central to the work of many geologists, ecologists, natural resource managers, and social scientists. Research over the last 15 years has led to an emerging consensus: the PDO is not a single phenomenon, but is instead the result of a combination of different physical processes, including both remote tropical forcing and local North Pacific atmosphere–ocean interactions, which operate on different time scales to drive similar PDO-like SST anomaly patterns. How these processes combine to generate the observed PDO evolution, including apparent regime shifts, is shown using simple autoregressive models of increasing spatial complexity. Simulations of recent climate in coupled GCMs are able to capture many aspects of the PDO, but do so based on a balance of processes often more independent of the tropics than is observed. Finally, it is suggested that the assessment of PDO-related regional climate impacts, reconstruction of PDO-related variability into the past with proxy records, and diagnosis of Pacific variability within coupled GCMs should all account for the effects of these different processes, which only partly represent the direct forcing of the atmosphere by North Pacific Ocean SSTs.
What Surface Observations Are Important for Separating the Influences of Anthropogenic Aerosols from Other Forcings?
Authors: Yan Xiaoqin , DelSole Timothy , Tippett Michael K. 
Published: March 2016

AbstractThis paper shows that joint temperature–precipitation information over a global domain provides a more accurate estimate of aerosol forced responses in climate models than does any other combination of temperature, precipitation, or sea level pressure. This fact is demonstrated using a new quantity called potential detectability, which measures the extent to which a forced response can be detected in a model. In particular, this measure can be evaluated independently of observations and therefore permits efficient exploration of a large number of variable combinations before performing optimal fingerprinting on observations. This paper also shows that the response to anthropogenic aerosol forcing can be separated from that of other forcings using only spatial structure alone, leaving the time variation of the response to be inferred from data, thereby demonstrating that temporal information is not necessary for detection. The spatial structure of the forced response is derived by maximizing the signal-to-noise ratio. For single variables, the north–south hemispheric gradient and equator-to-pole latitudinal gradient are important spatial structures for detecting anthropogenic aerosols in some models but not all. Sea level pressure is not an independent detection variable because it is derived partly from surface temperature. In no case does sea level pressure significantly enhance potential detectability beyond that already possible using surface temperature. Including seasonal or land–sea contrast information does not significantly enhance detectability of anthropogenic aerosol responses relative to annual means over global domains.