bluuebunny/crossref_metadata_2025_split huggingface dataset:
On efficiency of multistage channel with bargaining over wholesale prices
Authors: Zhong Feimin , Xie Jinxing , Zhao Xiaobo , Shen Zuo‐Jun Max 
Published: September 2016

AbstractThis article considers a multistage channel with deterministic price‐sensitive demand. Two systems for pricing decisions, that is, the bargaining system and the leader‐follower system, are compared. We characterize the necessary and sufficient conditions on the power structure, under which the solution of the bargaining system Pareto dominates that of the leader‐follower system. Also, under such conditions, we give a tight upper bound of channel efficiency of the bargaining system, which converges to 100% channel efficiency as the number of stages increases to infinity. © 2016 Wiley Periodicals, Inc. Naval Research Logistics 63: 449–459, 2016
An efficient dense and stable particular elements generation method based on geometry
Authors: OuYang Y. P. , Yang Q. , Yu L. 
Published: September 2016

SummaryIn this paper, a new discrete elements generation method based on geometry is proposed to fill geometric domains with particles (disks or spheres). By generating particles each one with a random radius or with a radius calculated from the iteration to ensure no overlaps exist between particles and identifying unstable particles and changing them to stable ones, a dense and stable packing can be created. A partitioning particle radius interval method and a particle stability inspection and improvement method are introduced to guarantee the algorithm's success and the stability of the particles. Some packings were created to evaluate the performances of the new method. The results showed that the algorithm was very efficient and was able to create isotropic packings of low porosities and large coordinate numbers. The partitioning particle radius interval method improved the generation efficiency significantly and increased the packing densities. Through the comparisons with several existing methods proposed recently, the method proposed in this work is found to be more efficient and can fill geometric domains with the lowest porosities. In addition, the stability of the particles is guaranteed and no complex triangular or tetrahedral mesh is required in particle generation, thereby making the new method simpler. Copyright © 2016 John Wiley & Sons, Ltd.
Modeling crack discontinuities without element‐partitioning in the extended finite element method
Authors: Chin E. B. , Lasserre J. B. , Sukumar N. 
Published: September 2016

SummaryIn this paper, we model crack discontinuities in two‐dimensional linear elastic continua using the extended finite element method without the need to partition an enriched element into a collection of triangles or quadrilaterals. For crack modeling in the extended finite element, the standard finite element approximation is enriched with a discontinuous function and the near‐tip crack functions. Each element that is fully cut by the crack is decomposed into two simple (convex or nonconvex) polygons, whereas the element that contains the crack tip is treated as a nonconvex polygon. On using Euler's homogeneous function theorem and Stokes's theorem to numerically integrate homogeneous functions on convex and nonconvex polygons, the exact contributions to the stiffness matrix from discontinuous enriched basis functions are computed. For contributions to the stiffness matrix from weakly singular integrals (because of enrichment with asymptotic crack‐tip functions), we only require a one‐dimensional quadrature rule along the edges of a polygon. Hence, neither element‐partitioning on either side of the crack discontinuity nor use of any cubature rule within an enriched element are needed. Structured finite element meshes consisting of rectangular elements, as well as unstructured triangular meshes, are used. We demonstrate the flexibility of the approach and its excellent accuracy in stress intensity factor computations for two‐dimensional crack problems. Copyright © 2016 John Wiley & Sons, Ltd.
The genetics and pathology of mitochondrial disease
Authors: Alston Charlotte L , Rocha Mariana C , Lax Nichola Z , Turnbull Doug M , Taylor Robert W 
Published: September 2016

AbstractMitochondria are double‐membrane‐bound organelles that are present in all nucleated eukaryotic cells and are responsible for the production of cellular energy in the form of ATP. Mitochondrial function is under dual genetic control – the 16.6‐kb mitochondrial genome, with only 37 genes, and the nuclear genome, which encodes the remaining ∼1300 proteins of the mitoproteome. Mitochondrial dysfunction can arise because of defects in either mitochondrial DNA or nuclear mitochondrial genes, and can present in childhood or adulthood in association with vast clinical heterogeneity, with symptoms affecting a single organ or tissue, or multisystem involvement. There is no cure for mitochondrial disease for the vast majority of mitochondrial disease patients, and a genetic diagnosis is therefore crucial for genetic counselling and recurrence risk calculation, and can impact on the clinical management of affected patients. Next‐generation sequencing strategies are proving pivotal in the discovery of new disease genes and the diagnosis of clinically affected patients; mutations in >250 genes have now been shown to cause mitochondrial disease, and the biochemical, histochemical, immunocytochemical and neuropathological characterization of these patients has led to improved diagnostic testing strategies and novel diagnostic techniques. This review focuses on the current genetic landscape associated with mitochondrial disease, before focusing on advances in studying associated mitochondrial pathology in two, clinically relevant organs – skeletal muscle and brain. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Novel insights into the diagnostic and therapeutic challenges of the CFTR metabolic syndrome/CF screen positive indeterminate diagnosis
Authors: Machogu Evans , Ren Clement L. 
Published: September 2016

SummaryThe growth of cystic fibrosis newborn screening (CF NBS) has led to an increased number of infants with a positive NBS test but inconclusive CF diagnostic testing. In the USA this condition is called CFTR related metabolic syndrome (CRMS), while in Europe the term CF screen positive, inconclusive diagnosis (CFSPID) is used. Recent advances in CF genetics and epidemiologic studies of CRMS/CFSPID have provided new insights into the prevalence and outcomes associated with this condition. Pediatr Pulmonol. 2016;51:S45–S48. © 2016 Wiley Periodicals, Inc.
Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging
Authors: Mall Marcus A. , Stahl Mirjam , Graeber Simon Y. , Sommerburg Olaf , Kauczor Hans‐Ulrich , Wielpütz Mark O. 
Published: September 2016

SummaryRecent imaging studies using chest computed tomography (CT) in presymptomatic infants and young children with cystic fibrosis (CF) diagnosed by newborn screening presented compelling evidence of early onset and progression of structural lung damage in CF. These data argue persuasively that non‐invasive outcome measures for early detection and sensitive monitoring of lung disease applicable in the clinical setting will be instrumental for further improvement of clinical care and the development of early intervention therapies that have the potential to prevent irreversible lung damage. In this context, the use of CT imaging for early detection and long‐term monitoring has the disadvantage of the risk to induce malignancies due to cumulating ionizing radiation exposure. More recently, magnetic resonance imaging (MRI) has emerged as an alternative radiation‐free imaging technique for quantitative assessment of CF lung disease. In addition to structural lung damage, chest MRI enables non‐invasive assessment of abnormalities in lung perfusion and ventilation characteristically associated with mucus plugging in CF lung disease. Here, we review recent developments and the prospects of MRI for improved and safer imaging with a focus on recent studies that support its utility as a sensitive non‐invasive outcome measure of early lung disease in young children with CF. Pediatr Pulmonol. 2016;51:S49–S60. © 2016 Wiley Periodicals, Inc.
Individualized medicine using intestinal responses to CFTR potentiators and correctors
Authors: Beekman Jeffrey M. 
Published: September 2016

SummaryCystic fibrosis transmembrane conductance regulator (CFTR) modulators that target the mutant CFTR protein are being introduced for treatment of cystic fibrosis. Stratification of subjects based on their CFTR genotype has been proven essential to demonstrate clinical efficacy of these novel treatments. Despite this stratification, considerable heterogeneity between subjects receiving CFTR modulators is still observed which remains largely uncharacterized. The CFTR genotype, and additional genetic and environmental factors that impact either tissue‐specific CFTR protein characteristics or the pharmacokinetic properties of treatments will likely determine the individual response to therapy. The development of intestinal biomarkers for CFTR modulators may help to better quantitate individual responses to treatment, with potential to optimize treatments for subjects with limited responses, and the selection of responsive subjects that currently do not receive treatments. Here, recent advances concerning the use of intestinal biomarkers for CFTR modulator treatments are reviewed, with a focus on biomarkers of CFTR function in ex vivo rectal biopsies and in vitro cultured primary intestinal organoids. Their potential value is considered in the context of the current unmet needs for better treatments for the majority of subjects with CF, and individual biomarkers that enable the prediction of long term therapeutic responses to CFTR modulators. Pediatr Pulmonol. 2016;51:S23–S34. © 2016 Wiley Periodicals, Inc.
Contemporary evidence-based practice in Canadian emergency medical services: a vision for integrating evidence into clinical and policy decision-making
Authors: Jensen Jan L. , Travers Andrew H. 
Published: September 2016

AbstractNationally, emphasis on the importance of evidence-based practice (EBP) in emergency medicine and emergency medical services (EMS) has continuously increased. However, meaningful incorporation of effective and sustainable EBP into clinical and administrative decision-making remains a challenge. We propose a vision for EBP in EMS: Canadian EMS clinicians and leaders will understand and use the best available evidence for clinical and administrative decision-making, to improve patient health outcomes, the capability and quality of EMS systems of care, and safety of patients and EMS professionals. This vision can be implemented with the use of a structure, process, system, and outcome taxonomy to identify current barriers to true EBP, to recognize the opportunities that exist, and propose corresponding recommended strategies for local EMS agencies and at the national level. Framing local and national discussions with this approach will be useful for developing a cohesive and collaborative Canadian EBP strategy.
Analyses of external and global intermittency in the logarithmic layer of Ekman flow
Authors: Ansorge Cedrick , Mellado Juan Pedro 
Published: September 2016

Existence of non-turbulent flow patches in the vicinity of the wall of a turbulent flow is known as global intermittency. Global intermittency challenges the conventional statistics approach when describing turbulence in the inner layer and calls for the use of conditional statistics. We extend the vorticity-based conditioning of a flow to turbulent and non-turbulent sub-volumes by a high-pass filter operation. This modified method consistently detects non-turbulent flow patches in the outer and inner layers for stratifications ranging from the neutral limit to extreme stability, where the flow is close to a complete laminarization. When applying this conditioning method to direct numerical simulation data of stably stratified Ekman flow, we find the following. First, external intermittency has a strong effect on the logarithmic law for the mean velocity in Ekman flow under neutral stratification. If instead of the full field, only turbulent sub-volumes are considered, the data fit an idealized logarithmic velocity profile much better; in particular, a problematic dip in the von Kármán measure$\unicode[STIX]{x1D705}$in the surface layer is decreased by approximately 50 % and our data only support the reduced range$0.41\lesssim \unicode[STIX]{x1D705}\lesssim 0.43$. Second, order-one changes in turbulent quantities under strong stratification can be explained by a modulation of the turbulent volume fraction rather than by a structural change of individual turbulence events; within the turbulent fraction of the flow, the character of individual turbulence events measured in terms of turbulence dissipation rate or variance of velocity fluctuations is similar to that under neutral stratification.
Faraday instability on a sphere: Floquet analysis
Authors: Ebo Adou Ali-higo , Tuckerman Laurette S. 
Published: September 2016

Standing waves appear at the surface of a spherical viscous liquid drop subjected to radial parametric oscillation. This is the spherical analogue of the Faraday instability. Modifying the Kumar & Tuckerman (J. Fluid Mech., vol. 279, 1994, pp. 49–68) planar solution to a spherical interface, we linearize the governing equations about the state of rest and solve the resulting equations by using a spherical harmonic decomposition for the angular dependence, spherical Bessel functions for the radial dependence and a Floquet form for the temporal dependence. Although the inviscid problem can, like the planar case, be mapped exactly onto the Mathieu equation, the spherical geometry introduces additional terms into the analysis. The dependence of the threshold on viscosity is studied and scaling laws are found. It is shown that the spherical thresholds are similar to the planar infinite-depth thresholds, even for small wavenumbers for which the curvature is high. A representative time-dependent Floquet mode is displayed.
Exploring the severely confined regime in Rayleigh–Bénard convection
Authors: Chong Kai Leong , Xia Ke-Qing 
Published: September 2016

We study the effect of severe geometrical confinement in Rayleigh–Bénard convection with a wide range of width-to-height aspect ratio $\unicode[STIX]{x1D6E4}$, $1/128\leqslant \unicode[STIX]{x1D6E4}\leqslant 1$, and Rayleigh number $Ra$, $3\times 10^{4}\leqslant Ra\leqslant 1\times 10^{11}$, at a fixed Prandtl number of $Pr=4.38$ by means of direct numerical simulations in Cartesian geometry with no-slip walls. For convection under geometrical confinement (decreasing $\unicode[STIX]{x1D6E4}$ from 1), three regimes can be recognized (Chong et al., Phys. Rev. Lett., vol. 115, 2015, 264503) based on the global and local properties in terms of heat transport, plume morphology and flow structures. These are Regime I: classical boundary-layer-controlled regime; Regime II: plume-controlled regime; and Regime III: severely confined regime. The study reveals that the transition into Regime III leads to totally different heat and momentum transport scalings and flow topology from the classical regime. The convective heat transfer scaling, in terms of the Nusselt number $Nu$, exhibits the scaling $Nu-1\sim Ra^{0.61}$ over three decades of $Ra$ at $\unicode[STIX]{x1D6E4}=1/128$, which contrasts sharply with the classical scaling $Nu-1\sim Ra^{0.31}$ found at $\unicode[STIX]{x1D6E4}=1$. The flow in Regime III is found to be dominated by finger-like, long-lived plume columns, again in sharp contrast with the mushroom-like, fragmented thermal plumes typically observed in the classical regime. Moreover, we identify a Rayleigh number for regime transition, $Ra^{\ast }=(29.37/\unicode[STIX]{x1D6E4})^{3.23}$, such that the scaling transition in $Nu$ and $Re$ can be clearly demonstrated when plotted against $Ra/Ra^{\ast }$.
Comparative risk of self-harm hospitalization amongst depressive disorder patients using different antidepressants: a population-based cohort study in Taiwan
Authors: Wu C.-S. , Liao S.-C. , Tsai Y.-T. , Chang S.-S. , Tsai H.-J. 
Published: September 2016

BackgroundThe aim of the study was to evaluate the comparative risk of self-harm associated with the use of different antidepressants.MethodA cohort study was conducted using data from Taiwan's National Health Insurance Research Database from 2001 to 2012. A total of 751 606 new antidepressant users with depressive disorders were included. The study outcome was hospitalization due to self-harm (International Classification of Diseases, Ninth Revision, Clinical Modification codes: E950–E958 and E980–E988). Cox proportional hazards models with stratification of the propensity score deciles were used to estimate the hazard ratios of self-harm hospitalization during the first year following the initiation of antidepressant treatment.ResultsThere were 1038 hospitalization episodes due to self-harm that occurred during the follow-up of 149 796 person-years, with an overall incidence rate of 6.9 [95% confidence interval (CI) 6.5–7.4] per 1000. Compared with fluoxetine, the risk of self-harm hospitalization was higher for maprotiline [adjusted hazard ratio (aHR) = 3.00, 95% CI 1.40–6.45], milnacipran (aHR = 2.34, 95% CI 1.24–4.43) and mirtazapine (aHR = 1.40, 95% CI 1.06–1.86), lower for bupropion (aHR = 0.51, 95% CI 0.30–0.86), and similar level of risk was found for other selective serotonin reuptake inhibitors (citalopram, escitalopram, fluvoxamine, paroxetine and sertraline).ConclusionsThe risk of self-harm may vary across different antidepressant drugs. It would be of importance to conduct further research to investigate the influence of antidepressant use on self-harm behaviors.
The effects of cognitive and behavioural therapies for anxiety disorders on depression: a meta-analysis
Authors: Cuijpers P. , Cristea I. A. , Weitz E. , Gentili C. , Berking M. 
Published: September 2016

BackgroundThe effects of cognitive behavioural therapy of anxiety disorders on depression has been examined in previous meta-analyses, suggesting that these treatments have considerable effects on depression. In the current meta-analysis we examined whether the effects of treatments of anxiety disorders on depression differ across generalized anxiety disorder (GAD), social anxiety disorder (SAD) and panic disorder (PD). We also compared the effects of these treatments with the effects of cognitive and behavioural therapies of major depression (MDD).MethodWe searched PubMed, PsycINFO, EMBASE and the Cochrane database, and included 47 trials on anxiety disorders and 34 trials on MDD.ResultsBaseline depression severity was somewhat lower in anxiety disorders than in MDD, but still mild to moderate in most studies. Baseline severity differed across the three anxiety disorders. The effect sizes found for treatment of the anxiety disorders ranged from g = 0.47 for PD, g = 0.68 for GAD and g = 0.69 for SAD. Differences between these effect sizes and those found in the treatment of MDD (g = 0.81) were not significant in most analyses and we found few indications that the effects differed across anxiety disorders. We did find that within-group effect sizes resulted in significantly (p < 0.001) larger effect sizes for depression (g = 1.50) than anxiety disorders (g = 0.73–0.91). Risk of bias was considerable in the majority of studies.ConclusionsPatients participating in trials of cognitive behavioural therapy for anxiety disorders have high levels of depression. These treatments have considerable effects on depression, and these effects are comparable to those of treatment of primary MDD.
BAAL/CUP Seminar 2015: Eyetracking as a research method in online language education
Authors: Stickler Ursula , Shi Lijing 
Published: September 2016

The seminar took place at The Open University, Milton Keynes, United Kingdom, 12–13 June 2015.The objectives of this seminar were to explore the use of eyetracking in advancing online language education, and to provide a platform for the exchange of ideas across disciplines (language, education, and computing). The overarching aim was to lay the foundations for a network to support future eyetracking research collaboration on the practical, methodological and theoretical level.
Increasing subsequences of random walks
Authors: ANGEL OMER , BALKA RICHÁRD , PERES YUVAL 
Published: September 2016

AbstractGiven a sequence ofnreal numbers {Si}i⩽n, we consider the longest weakly increasing subsequence, namelyi1<i2< . . . <iLwithSik⩽Sik+1andLmaximal. When the elementsSiare i.i.d. uniform random variables, Vershik and Kerov, and Logan and Shepp proved that${\mathbb E} L=(2+o(1)) \sqrt{n}$.We consider the case when {Si}i⩽nis a random walk on ℝ with increments of mean zero and finite (positive) variance. In this case, it is well known (e.g., using record times) that the length of the longest increasing subsequence satisfies${\mathbb E} L\geq c\sqrt{n}$. Our main result is an upper bound${\mathbb E} L\leq n^{1/2 + o(1)}$, establishing the leading asymptotic behavior. If {Si}i⩽nis a simple random walk on ℤ, we improve the lower bound by showing that${\mathbb E} L \geq c\sqrt{n} \log{n}$.We also show that if {Si} is a simple random walk in ℤ2, then there is a subsequence of {Si}i⩽nof expected length at leastcn1/3that is increasing in each coordinate. The above one-dimensional result yields an upper bound ofn1/2+o(1). The problem of determining the correct exponent remains open.
Neuropathology in Canada: The First One Hundred Years
Authors: Del Bigio Marc R. , Barry Rewcastle N. 
Published: September 2016

AbstractWe describe the evolution of neuropathology in Canada, beginning with William Osler who began working in Montréal in 1874 and finishing with the major period of expansion in the 1970s. Organized services began in the 1930s, in Montréal with the neurosurgeons Wilder Penfield and William Cone, and in Toronto with Eric Linell and Mary Tom, who both began their careers as neuroanatomists. Jerzy Olszewski and Gordon Mathieson, who trained in Montréal and Toronto, drove the creation of the CanadianAssociation of Neuropathologists in 1960. Training guided by the Royal College of Physicians and Surgeons of Canada was formalized in 1965, with the first certifying examination in 1968 and the subsequent creation of formal structured training programs. The number of neuropathologists in Canada increased rapidly through the 1960s and 1970s, with individuals coming from both clinical neuroscience and anatomic pathology backgrounds, a pattern that persists to the present day.
Multiple Sclerosis - A Vascular Etiology?
Authors: Weir Bryce 
Published: September 2016

AbstractFrom the earliest pathological studies the perivenular localization of the demyelination in multiple sclerosis (MS) has been observed. It has recently been suggested that obstructions to venous flow or inadequate venous valves in the great veins in the neck, thorax and abdomen can cause damaging backflow into the cerebral and spinal cord circulations. Paolo Zamboni and colleagues have demonstrated abnormal venous circulation in some multiple sclerosis patients using non-invasive sonography and invasive venography. Furthermore, they have obtained apparent clinical improvement or stabilization by endovascular ballooning of points of obstruction in the great veins in some, at least temporarily. If non-invasive observations by others validate their initial observations of a significantly increased prevalence of venous obstructions in MS then trials of angioplasty/stenting would be justified in selected cases in view of the biological plausibility of the concept.