bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Treatment Patterns for Metastatic Renal Cell Carcinoma in Brazil
Authors: Bergerot Paulo G. , Bergerot Cristiane D. , Dizman Nazli , Zequi Stenio , Fay Andre , Dara Yash , Maia Manuel Caitano , Cotta Brendan N. , Gonçalves Edna Prado , Formiga Maria Nirvana , Tariki Milena Shizue , Clavijo Diego Abreu , Choueiri Toni K. , Lopes Gilberto , Pal Sumanta K. 
Published: December 2017

Background Although multiple therapies have emerged for the treatment of metastatic renal cell carcinoma (mRCC), it is unclear whether application of these agents is consistent in developed and developing countries. We sought to determine patterns of care for mRCC in Brazil as a representative developing country. Material and Methods A commercial database was used to acquire information pertaining to patients with mRCC receiving treatment at private or public hospitals in Brazil between March 2013 and October 2016. Basic clinical and demographic criteria were available, as well as information to ascertain the International Metastatic Renal Cell Carcinoma Database Consortium risk. Treatment-related data across multiple lines of therapy were collected. Results Of 4,379 patients assessed, 3,990 (91%) had metastatic disease, and 26%, 48%, and 26% of patients had good, intermediate, and poor International Metastatic Renal Cell Carcinoma Database Consortium risk disease, respectively. Although 3,149 patients (79%) received first-line therapy, only 641 (20%) and 152 (5%) received second- and third-line therapy, respectively. In the first-line setting, vascular endothelial growth factor–directed agents represented the most commonly used therapy, whereas in the second-line setting, vascular endothelial growth factor– and mammalian target of rapamycin–directed agents were used with similar frequency. Marked differences were seen in receipt of systemic therapy on the basis of treatment in private or public hospitals. Conclusion Relative to developed countries, marked attrition is noted between each subsequent line of therapy in Brazil. Patterns of care also vary greatly in private and public settings, pointing to financial constraints as a potential cause for discordances in treatment.
Improved Synthesis of the A–E Ring Segment of Ciguatoxin CTX3C by Using Intramolecular Allylations
Authors: Tanaka Tokihiro , Asakura Hiroki , Fujiwara Rie , Kumamoto Kentaro , Izuka Hiroaki , Shiroma Kengo , Takamura Hiroyoshi , Kadota Isao 
Published: December 2017

Abstract
An improved synthesis of the A–E ring segment of ciguatoxin CTX3C is described. The E ring segment was synthesized by the intramolecular reaction of allylic stannane and aldehyde with high stereoselectivity. Construction of the A–E ring framework was performed by using the intramolecular allylation of α-acetoxy ether followed by ring-closing metathesis.
Information Systems Projects and Individual Developer Outcomes: Role of Project Managers and Process Control
Authors: Venkatesh Viswanath , Rai Arun , Maruping Likoebe M. 
Published: December 2017

We integrate control theory and the information systems (IS) project management literature using a multilevel lens to theorize the cross-level effects of technical IS project risk on individual developer outcomes—performance and psychological stress—and the mechanisms by which IS project managers’ project-related knowledge attenuates this relationship. We argue that IS project managers with project-related knowledge mitigate technical IS project risk by facilitating the enactment of internal and external process controls in their IS projects. Our empirical study involves data collected from 1,230 individual developers embedded in 130 IS project teams that are managed by 20 IS project managers. Our results provide strong support for the three-level model and its set of (a) cross-level main effects of technical IS project risk on individual developer outcomes; (b) cross-level main effects of IS project manager project-related knowledge on enacted internal and external process controls; and (c) cross-level moderation of the relationship between technical IS project risk and individual developer outcomes by IS project manager project-related knowledge through internal and external process controls. Our study provides insights on how IS project management, IS project process controls, and technical IS project risk must be managed as a system of multilevel dependencies to achieve the desired developer outcomes. The online appendix is available at https://doi.org/10.1287/isre.2017.0723 .
Simulating Macro-Level Effects from Micro-Level Observations
Authors: Smith Edward Bishop , Rand William 
Published: December 2017

We consider the fruits of integrating agent-based modeling (ABM) with lab-based experimental research with human subjects. While both ABM and lab experiments have similar aims—to identify the rules, tendencies, and heuristics by which individual agents make decisions and respond to external stimuli—they work toward their common goal in notably different ways. Behavioral-lab research typically exposes human subjects to experimental manipulations, or treatments, to make causal inferences by observing variation in response to the treatment. ABM researchers ascribe individual simulated “agents” with decision rules describing their behavior and subsequently attempt to replicate “macro” level empirical patterns. Integration of ABM and lab experiments presents advantages for both sets of researchers. ABM researchers will benefit from exposure to a larger set of empirically validated mechanisms that can add nuance and refinement to their models of human behavior and system dynamics. Lab-oriented researchers will gain from ABM a method for assessing the validity and magnitude of their findings, adjudicating between competing mechanisms, developing new theory to test in the lab, and exploring macro-level, long-run implications of subtle, micro-level observations that can be difficult to observe in the field. We offer an example of this mixed-method approach related to status, social networks, and job search and issue guidance for future research attempting such integration. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2877 . This paper was accepted by Yuval Rottenstreich, judgment and decision making.
WORK ON ISRAELI-PALESTINIAN CONFLICT
Authors: Islam Rafikul 
Published: December 2017

Professor Thomas L. Saaty is a world-renowned Operations Research (OR) scientist. His death has created a vacuum which can hardly be filled. His absence in scholastic writing in the field of MCDM will be widely felt for a long time. The world of OR will remember him not only as a mathematician, originator of AHP and ANP, but also as a good human being. He has numerous contributions in the field of OR, particularly MCDM. In the present article, I have highlighted his wonderful contribution in resolving the decades-long Israeli-Palestinian conflict. https://doi.org/10.13033/ijahp.v9i3.523
REFLECTIONS ON PRIORITIZING DIVERGENT INTANGIBLE HUMANE ACTS
Authors: Shang Jennifer 
Published: December 2017

AHP is a versatile tool for prioritizing and making decisions. Yet, when facing numerous alternatives with significantly different scale, decision makers often found it impossible to put them together in one matrix and compare them simultaneously. To address the issue, Thomas Saaty and I (2011) proposed a new Analytic Hierarchy Process-based structure to capture the complex relationship between various levels of activities. Without the proposed model, we may not be able to tackle alternatives that are not comparable or it may require a very large number of comparisons, as only comparable items can be compared and used to calculate meaningful priorities. In this paper, we show how to use clustering and pivots to handle this difficulty. Through the proposed method, we expand the comparison scale, build a near-consistent matrix, and allow the use of incomparable alternatives. The proposed method helps us effectively derive priorities for alternatives with orders-of-magnitude differences like those in divergent intangible humane acts.https://doi.org/10.13033/ijahp.v9i3.536
Autonomy Support, Need Satisfaction, and Motivation for Support Among Adults With Intellectual Disability: Testing a Self-Determination Theory Model
Authors: Frielink Noud , Schuengel Carlo , Embregts Petri J. C. M. 
Published: December 2017

AbstractThe tenets of self-determination theory as applied to support were tested with structural equation modelling for 186 people with ID with a mild to borderline level of functioning. The results showed that (a) perceived autonomy support was positively associated with autonomous motivation and with satisfaction of need for autonomy, relatedness, and competence; (b) autonomous motivation and need satisfaction were associated with higher psychological well-being; (c) autonomous motivation and need satisfaction statistically mediated the association between autonomy support and well-being; and (d) satisfaction of need for autonomy and relatedness was negatively associated with controlled motivation, whereas satisfaction of need for relatedness was positively associated with autonomous motivation. The self-determination theory provides insights relevant for improving support for people with intellectual disability.
Later Life Impacts of Social Participation on Parents of Adult Offspring With and Without Intellectual and Developmental Disabilities
Authors: Olsen Darren L. , Floyd Frank J. , Mailick Marsha R. , Greenberg Jan S. 
Published: December 2017

Abstract
Social participation is an important resource for parents in old age, and may be particularly important for parents living with adult offspring with intellectual and developmental disabilities. To evaluate whether socializing with friends and family and participating in social organizations protects against depression in old age, this study examined parents of adult offspring with disabilities (n = 164) and without disabilities (n = 820). As expected, more socializing with friends and more participating in organizations were associated with fewer depressive symptoms for all parents. However, socializing with family members predicted fewer depressive symptoms only for parents co-residing with their adult offspring with disabilities, suggesting that socializing with family is particularly important for parents providing direct care to adults with disabilities.
Espondilodiscitis en pediatría
Authors: Pareja Zabala María Camila , Cerchiaro Mejía María Camila , Restrepo Centeno Natalia 
Published: December 2017

Introducción:
La Discitis o Espondilodiscitis es una entidad poco frecuente en pediatría, la cual, en términos de fisiopatología y manifestaciones clínicas, es muy controvertida. Se presenta un reporte de caso, de una paciente de 3 años, quien consulta al servicio de urgencias por presentar marcha antálgica progresiva. Se hizo un enfoque diagnóstico inicial mediante una resonancia magnética nuclear (RMN) que reporto una Espondilodiscitis. Se dio tratamiento integral con antibioticoterapia y antiinflamatorio, logrando una evolución satisfactoria.
Presentación del caso:
Paciente de 3 años de edad, de sexo femenino, quien consulto por cuadro clínico de 20 días de evolución, consistente en marcha antálgica progresiva asociada a irritabilidad, signos y síntomas ventilo-respiratorios, sin antecedentes de importancia. Ante hallazgos clínicos e imageneológicos se realizó el diagnóstico de Espondilodiscitis. Se inició antibioticoterapia, manejo antiinflamatorio y, adicionalmente, se ordenó reposo y rehabilitación física. La paciente evolucionó de manera satisfactoria por lo cual se dio egreso hospitalario.
Conclusiones:
Aun cuando la Espondilodiscitis es una patología poco frecuente y auto-limitada, es importante tenerla en cuenta entre los diagnósticos diferenciales debido a sus potenciales complicaciones. La resonancia magnética es el estándar de oro para el diagnóstico temprano. El tratamiento integral incluye reposo en cama inicial, antiinflamatorios, en algunos casos, antibioticoterapia y rehabilitación física.
EFECTO DE DIETAS EN ADULTOS DE Spodoptera cosmioides (LEPIDOPTERA: NOCTUIDAE) SOBRE LA FERTILIDAD, FECUNDIDAD Y LONGEVIDAD DEL ADULTO
Authors: CURIS M. C. , BERTOLACCINI I. , LUTZ A. 
Published: December 2017

La aparición de cultivares de soja Bt + RR2Y determinó la emergencia de una nueva plaga, Spodoptera cosmioides, una plaga altamente polífaga de amplia distribución. La cría de insectos en cámaras de cría es necesaria para estudios de investigación básica y aplicada. El objetivo del trabajo fue evaluar el efecto de tres dietas ricas en carbohidratos (solución de miel, de jarabe de glucosa y de jarabe de maíz) en la alimentación de los adultos y determinar su efecto sobre la fecundidad, fertilidad y supervivencia de S. cosmioides. Se determinó que, si bien no se hallaron diferencias entre los tratamientos, la composición de los azúcares de las dietas, puede afectar los parámetros reproductivos de esta plaga, ya que las hembras alimentadas con solución de miel natural, más rica en compuestos orgánicos, aumentaron la fecundidad, refl ejado en una mayor puesta y eclosión de huevos y la longevidad de los adultos.
EFECTO DE LA TEMPERATURA Y SALINIDAD EN LA GERMINACIÓN Y CRECIMIENTO INICIAL DE UN MATERIAL NATURALIZADO DE Lotus tenuis WALDST. & KIT
Authors: MARINONI L. , ZABALA J. M. , PATIÑO J. , PENSIERO J. F. 
Published: December 2017

Lotus tenuis Waldst. & Kit es una leguminosa perenne tolerante a la salinidad, con difi cultades en su implantación en el centro-norte de Argentina debido al estrés térmico e hídrico sufrido durante el verano. En el presente estudio se evaluó el comportamiento germinativo y crecimiento inicial de una población naturalizada de L. tenuis del centro-norte de Santa Fe, comparado con el cultivar comercial Aguapé. Se analizaron diferentes temperaturas constantes y alternas de germinación y se evaluó el crecimiento inicial en condiciones controladas de luz y temperatura, en ausencia y presencia de estrés salino. Altas temperaturas afectaron negativamente la germinación en ambos materiales, en ausencia y presencia de salinidad, hallándose la mayor tolerancia a salinidad a la temperatura constante más baja y alterna. La presencia de sales afectó la producción de biomasa en crecimiento inicial, aunque la partición no se vio afectada.El cv. comercial Aguapé, presentó mayor producción de biomasa que el material naturalizado.
RUPTURA DE LA DORMICIÓN Y EXIGENCIAS DE LUZ PARA LA GERMINACIÓN DE SEMILLAS DE Juglans nigra
Authors: FLORES P. , POGGI D. , GARCIA, S. , CATRARO M. , GARIGLIO N. 
Published: December 2017

Se evaluaron métodos para superar la dormición y determinar las necesidades de luz en la germinación de Juglans nigra. Para superar la latencia y dureza del endocarpio se realizó Estratificación en caliente (T1), Inmersión en ácido giberélico (T2) y Estratifi cación en frío húmedo (T3). Para la necesidad de luz se evaluó alternancia de oscuridad/luz y oscuridad permanente. Se analizó el Porcentaje Germinación (% de G), Índice Velocidad de Germinación (IVG), Tiempo Medio Germinación Máxima (TMG), % Plántulas Normales, % Semillas sin germinar, Peso Seco Medio de plántulas (PSM) y el Índice de Germinación Relativo a la luz (GRL). En T1 no hubo germinación y en T2 irrelevante. T3 produjo diferencias altamente significativas en todas las variables analizadas, siendo el período de 4 meses de estratifi cación el mejor para romper la dormición. Al no ser la luz un factor determinante en la germinación, esta especie se clasifi caría como fotoblástica neutra.
REHABILITACION DE SUELOS HORTÍCOLAS: IMPACTO DE PRÁCTICAS AGRÍCOLAS CON USO DE YESO Y DRENAJE
Authors: MUGUIRO A. , ÁLVAREZ C. , BABINEC F. , MARANO R. 
Published: December 2017

El exceso de Na + , carbonatos y bicarbonatos presentes en el agua de riego incrementan el pH, la conductividad eléctrica (CE) y el porcentaje de sodio intercambiable (PSI), afectando el crecimiento de los cultivos. El objetivo de este trabajo fue cuantifi car el impacto de prácticas de manejo con aplicación de yeso y drenaje en suelos petrocálcicos de La Pampa afectados por riego con aguas subterráneas bicarbonatadas sódicas. Se cultivó lechuga durante cuatro ciclos (500 días) en dos invernáculos diferenciados por la cantidad previa de años de riego, utilizando un diseño factorial completamente aleatorizado con 4 submuestras (unidades de medición). Los tratamientos en ambos túneles (2 años=B1 y 4 años=B2) fueron: 1) T0, testigo sin tratar; 2) T1, 3,5 Mg ha -1 de yeso agrícola, 3) T2, 3,5 Mg ha -1 de yeso agrícola + drenaje y 4) T3, drenaje. La incorporació de yeso disminuyó la concentración de Na + y PSI signifi cativamente desde superfi cie hasta 0,4 m. También mejoró signifi cativamente las condiciones físicas del suelo en el túnel B2, aspecto que se manifestó con un incremento de la productividad acumulada del cultivo de lechuga. En cambio no se encontraron diferencias signifi cativas en el pH del suelo en ninguna de las profundidades evaluadas. Adicionalmente, la CE del suelo con los diferentes tratamientos disminuyó notablemente a partir del 2o ciclo de producción debido al incremento en la dosis de riego.
EVALUACIÓN DE LA SITUACIÓN PRODUCTIVA DE SECTOR LECHERO DEL DISTRITO PILAR Y SU IMPACTO ECONÓMICO Y SOCIAL EN LA REGIÓN DE INFLUENCIA
Authors: OSAN O. , ROSSLER N. , ACETTA P. , CASTIGNANI M. I. 
Published: December 2017

Este trabajo tiene como objetivo la caracterización y diagnóstico del sector lechero primario del Distrito Pilar, Provincia de Santa Fe, Argentina, a fi n de evaluar su situación productiva y el impacto económico y social sobre el desarrollo de su región de infl uencia. Los datos relevados corresponden a las 24 empresas del distrito, dedicadas principalmente a la producción de leche. Entre las principales conclusiones se destaca el impacto social de las mismas, aportando a una comunidad de 5.500 habitantes, 37.000.000 de litros de leche, aproximadamente 700 puestos de trabajo y un circuito fi nanciero de aproximadamente $ 184.000.000 anuales y centralizando sus actividades sociales y económicas (gastos y comercialización de insumos y productos) en la comunidad de Pilar. Se destaca la presencia de nuevas generaciones apostando por seguir en el rubro, muchos de ellos capacitados y comprometidos con la empresa.
Developing and Implementing Next-Generation Computer-Aided Dispatch: Challenges and Opportunities
Authors: Shahrah Abobakr Y. , Al-Mashari Majed A. , Hossain M. Anwar 
Published: December 2017

Abstract
The Computer-Aided Dispatch (CAD) system is an essential element of public safety to streamline the emergency response process and enable real-time information sharing. With the introduction of Next Generation 9-1-1 (NG9-1-1), there is great potential to enhance the functionalities and capabilities of the conventional CAD system. However, the transition to NG9-1-1 and the implementation of the Next Generation CAD (NGCAD) system are both challenging and very slow owing to many constraints. This paper aims to explore and discuss the current challenges and future trends that have an impact on developing and implementing NGCAD. More specifically, it highlights current technological and non-technological challenges associated with NG9-1-1 and outlines how the emerging technologies can help in resolving them. We predict that this paper will benefit all CAD system stakeholders, including public safety and industry professionals, by increasing the awareness of the NGCAD system’s evolution and the capabilities it is required to have within the context of NG9-1-1.
Un estudio sobre el comercio sexual de mujeres y publicidad. El papel de la prensa española
Authors: Rodríguez Borges Rodrigo Fidel , Torrado Martín-Palomino Esther 
Published: December 2017

Este texto reflexiona sobre el papel de la prensa española en la comercialización sexual de mujeres a través de la publicidad de contactos que insertan en sus páginas, tomando como punto de partida una muestra de 860 anuncios aparecidos en los principales diarios españoles durante 2016. De una parte, se analizan las claves del discurso publicitario de la prostitución, que presenta como rasgos principales la hipersexualización de los atributos físicos de las mujeres, la reproducción de los roles tradicionales de género y la racialización-etnificación de la oferta, que se relaciona con la intensificación de los flujos migratorios dirigidos a España. De otra parte, se presenta el debate ético-jurídico sobre esta clase de publicidad, inexistente en la prensa europea de referencia, pero generalizada en los periódicos españoles
A Sociocultural Perspective Surrounding the Application of Global Positioning System Technology: Suggestions for the Strength and Conditioning Coach
Authors: Jones Luke , Denison Jim 
Published: December 2017

ABSTRACT
AN INCREASED USE OF GLOBAL POSITIONING SYSTEM (GPS) MONITORING WITHIN PROFESSIONAL SPORT HAS LED TO AN EVOLUTION IN THE ROLE OF THE STRENGTH AND CONDITIONING (S&C) COACH. THIS ROLE CONTINUES TO GRAVITATE TOWARD A GREATER EMPHASIS ON THE COLLECTION, DISCERNMENT, AND APPLICATION OF GPS DATA. HOWEVER, THERE ARE NUMEROUS IMPLICATIONS SURROUNDING THE USE OF MONITORING TECHNOLOGIES BY COACHES THAT SPORT SOCIOLOGISTS HAVE SHOWN THROUGH THE WORK OF FRENCH PHILOSOPHER MICHEL FOUCAULT THAT CAN BE POTENTIALLY PROBLEMATIC FOR ATHLETES' DEVELOPMENT. S&C COACHES NOW REQUIRE GUIDANCE TO HELP THEM TO USE THESE TOOLS. HERE, WE PRESENT SOME SUGGESTIONS TO HELP THE S&C COACH IN THIS ENDEAVOR.
Investigation of surface roughness and material removal rate for UD-GFRP composite using Taguchi grey relational analysis
Authors: Kumar Surinder , Meenu  
Published: December 2017

In this paper, a grey relational method was used for minimising surface roughness and maximising material removal rate during turning of unidirectional glass fibre reinforced plastic composite (UD-GFRP). Taguchi approach was used for the experiment. The parameters studied were tool rake angle, speed, depth of cut, feed, tool nose radius, and cutting environment. Castrol water (1:6) miscible soluble coolant was flooded in the machining zone. Cutting environment: Wet (33°-38°c) and Cold (5°-7°c) were used. The Taguchi L18 orthogonal array was used for performing the experiment. Significant parameters were found by applying ANOVA. The grey relational analysis was used to optimise the parameters affecting the response. Cutting speed was the factor, followed by feed rate that influenced surface roughness and material removal rate. The surface roughness of 1.761 µm and material removal rate of 275.78 mm3 were achieved.
Fine Mapping of QUICK ROOTING 1 and 2, Quantitative Trait Loci Increasing Root Length in Rice
Authors: Kitomi Yuka , Nakao Emari , Kawai Sawako , Kanno Noriko , Ando Tsuyu , Fukuoka Shuichi , Irie Kenji , Uga Yusaku 
Published: December 2017

Abstract
The volume that the root system can occupy is associated with the efficiency of water and nutrient uptake from soil. Genetic improvement of root length, which is a limiting factor for root distribution, is necessary for increasing crop production. In this report, we describe identification of two quantitative trait loci (QTLs) for maximal root length, QUICK ROOTING 1 (QRO1) on chromosome 2 and QRO2 on chromosome 6, in cultivated rice (Oryza sativa L.). We measured the maximal root length in 26 lines carrying chromosome segments from the long-rooted upland rice cultivar Kinandang Patong in the genetic background of the short-rooted lowland cultivar IR64. Five lines had longer roots than IR64. By rough mapping of the target regions in BC4F2 populations, we detected putative QTLs for maximal root length on chromosomes 2, 6, and 8. To fine-map these QTLs, we used BC4F3 recombinant homozygous lines. QRO1 was mapped between markers RM5651 and RM6107, which delimit a 1.7-Mb interval on chromosome 2, and QRO2 was mapped between markers RM20495 and RM3430-1, which delimit an 884-kb interval on chromosome 6. Both QTLs may be promising gene resources for improving root system architecture in rice.