bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decontamination Work and the Long-term Increase in Hospital Visits for Hymenoptera Stings Following the Fukushima Nuclear Disaster
Authors: Ozaki Akihiko , Yokota Takeru , Nomura Shuhei , Tsubokura Masaharu , Leppold Claire , Tanimoto Tetsuya , Miura Toru , Yamamoto Kana , Sawano Toyoaki , Tsukada Manabu , Kami Masahiro , Kanazawa Yukio , Ohira Hiromichi 
Published: March 2017

AbstractObjectiveAnimals, including arthropods, are one health threat that can be affected by disasters. This institution-based study aimed to assess trends in Hymenoptera stings following the 2011 Fukushima nuclear disaster.MethodsWe reviewed the medical records of patients with hymenopteran stings who visited Minamisoma Municipal General Hospital, located 23 km from Fukushima Daiichi Nuclear Power Plant, from March 2005 to March 2016. Patient and sting characteristics of post-disaster patients were examined, and the annual incidence of hospital visits for hymenopteran stings was compared with the pre-disaster baseline, calculating an incidence rate ratio (IRR) for each year.ResultsWe identified 152 pre-disaster patients (2005-2011) and 222 post-disaster patients (2011-2016). In the post-disaster period, 160 males (72.1%) were identified, with a median age of 59 years (range: 2-89 years). A total of 45 patients (20.3%) were decontamination workers. Post-disaster increases were found in the IRR for hymenopteran stings, peaking first in 2011 (IRR: 2.8; 95% confidence interval [CI]: 1.9-4.2) and later in 2014 (IRR: 3.2; 95% CI: 2.4-4.3) and 2015 (IRR 3.3; 95% CI: 2.5-4.4).ConclusionsLong-term increases were found in the IRR of hospital visits for hymenopteran stings in an institution affected by the Fukushima nuclear disaster. Decontamination workers appear to have been particularly affected by this phenomenon. Better disaster field worker monitoring and education about potential environmental health hazards may help to identify and prevent worker exposure to insect stings and other vectors in these settings. (Disaster Med Public Health Preparedness. 2017;11:545–551)
PRÉCIS AND REPLIES TO CONTRIBUTORS FOR BOOK SYMPOSIUM ONACCURACY AND THE LAWS OF CREDENCE
Authors: Pettigrew Richard 
Published: March 2017

ABSTRACTThis book symposium onAccuracy and the Laws of Credenceconsists of an overview of the book’s argument by the author, Richard Pettigrew, together with four commentaries on different aspects of that argument. Ben Levinstein challenges the characterisation of the legitimate measures of inaccuracy that plays a central role in the arguments of the book. Julia Staffel asks whether the arguments of the book are compatible with an ontology of doxastic states that includes full beliefs as well as credences. Fabrizio Cariani raises concerns about the argument offered in the book for various chance-credence principles. And Sophie Horowitz questions the assumptions at play in the book’s argument for the Principle of Indifference, as well as asking how the various laws of credence considered in the book relate to one another.
Biography in African History
Authors: Lindsay Lisa A. 
Published: March 2017

Abstract:This paper charts the rise and transformation of biography as a form of Africanist history writing. Biography in African history, as in other fields, has included attention to nationalist heroes as well as the lives of slaves, women, and other subalterns. Recently, some Africanist historians have embraced transnational life histories, particularly those situated in the “black Atlantic” of the eighteenth and nineteenth centuries. Some themes, methods, and limitations of such biographies are discussed in relation to the author’s own project on a nineteenth century immigrant to West Africa.
Food Addiction Does Not Explain Weight Gain in Smoking Cessation
Authors: Amer Nordin Amer Siddiq , Adamson Simon Justin , Sellman John Douglas 
Published: March 2017

Introduction: Weight gain during smoking cessation is a major concern. The relationship between smoking and weight is complex and not well understood. There is interest in substitution of nicotine with food.Aims: This study investigates whether the development of food addiction explains weight gain following a quit smoking attempt.Methods: This study was a subset of a larger study investigating smoking cessation in New Zealand. Participants were assessed on five visits over a 1-year period. Using validated instruments, measurements for smoking, weight, food intake, craving and food addiction were taken.Results: Among the 256 participants, 54.7% attended at least one follow-up. Food addiction prevalence at baseline was 0.8%. 14.5% were quit at early follow-up and 14.8% at late follow-up. Weight gain was found in abstainers compared to those still smoking. No increase in food addiction was detected.Conclusion: The development of food addiction does not play a prominent role in post quit weight gain. Further research is needed to elucidate the underlying weight gain mechanisms.
ASSISTING MRS TOMMY ATKINS: GENDER, CLASS, PHILANTHROPY, AND THE DOMESTIC IMPACT OF THE SOUTH AFRICAN WAR, 1899–1902
Authors: RIEDI ELIZA 
Published: March 2017

AbstractDespite the well-established historiography examining the South African war's impact upon British society, little attention has been paid to the plight of British soldiers’ families or to the charitable efforts mobilized to maintain them in the absence of adequate state support. This article, focusing on the key charity in the field, the Soldiers’ and Sailors’ Families Association (SSFA), examines the SSFA's wartime policies and considers how the Association's actions influenced subsequent state policy-making. It explores the motivations and attitudes of its middle-class, mostly female, volunteers, on whose sustained commitment the work of the SSFA depended. In analysing the sources of the SSFA's funding, it considers how class and regionality shaped public giving to patriotic philanthropy. Finally, it investigates how perceptions of soldiers’ wives and mechanisms for their support in the First World War were affected by the South African war experience. Overall, the article aims both to demonstrate the importance of philanthropic aid to soldiers’ families in understanding the domestic impact of this imperial war, and to trace the longer-term effects on the development of policies towards servicemen's dependants.
Assessment of the Knowledge of Blast Injuries Management among Physicians Working in Tripoli Hospitals (Libya)
Authors: Oun Abdulhakim M. , Hadida Elmokhtar M. , Stewart Charles 
Published: March 2017

AbstractIntroductionNo study on hospital staff preparedness for managing blast injuries has been conducted in Libya. The internal conflict in Libya since 2011 and the difficulties faced by the hospitals has highlighted the need for such studies.HypothesisPhysicians working in Tripoli (capital city Libya) hospitals are inadequately prepared for the management of blast injuries.MethodsA survey was conducted in all 13 hospitals in Tripoli between June 2014 and May 2015 by using interviews based on a questionnaire consisting of 29 questions covering physicians’ education related to blast injury, hospital management of mass casualties, and aspects of hospital preparedness for such incidents.ResultsOf 3,799 physicians working in Tripoli hospitals, 607 physicians were interviewed (16.0%). All but one of the physicians reported that there was no disaster response plan, none of them had read such a plan, 496 (81.7%) reported that hospitals were not prepared, and 471 (77.6%) that hospitals were not equipped for blast injuries. Though 414 (68.2%) reported that radiological equipment was available, 597 (98.3%) revealed that hospitals do not adopt training for blast injury. Only 39 (6.4%) had received professional training, though 183 (30.1%) were seeing blast injury patients at least once a week in their daily practice. Nevertheless, 185 (30.5%) had previous knowledge and experience in blast injuries management and 338 (55.70%) were aware of the major physical findings, but only 75 (12.4%) were following specific guidelines. According to approximately one-third of the physicians (192; 31%), staff and patient safety were not priorities for the hospital administration. Almost all (606; 99.9%) revealed that personal protective equipment for chemical and nuclear accidents was not available.ConclusionPreparedness for blast injuries in Tripoli hospitals is seriously deficient. Planning optimized blast and disaster management in Libya is essential.OunAM,HadidaEM,StewartC.Assessment of the knowledge of blast injuries management among physicians working in Tripoli hospitals (Libya).Prehosp Disaster Med.2017;32(3):311–316.
Diet quality on meatless days: National Health and Nutrition Examination Survey (NHANES), 2007–2012
Authors: Conrad Zach , Karlsen Micaela , Chui Kenneth , Jahns Lisa 
Published: March 2017

AbstractObjectiveTo compare diet quality scores between adult non-meat eaters and meat eaters, and to compare the consumption of diet components across quintiles of diet quality.DesignCross-sectional analysis. The Healthy Eating Index-2010 (HEI-2010) and Alternative Healthy Eating Index-2010 (AHEI-2010) were used to assess mean diet quality. Differences in consumption of diet components between quintiles of diet quality were tested usingpost hocWald tests andztests.SettingThe National Health and Nutrition Examination Survey (NHANES), 2007–2012.SubjectsThe sample consisted of 16810 respondents aged≥18 years, including 280 individuals who reported not consuming meat, poultry, game birds or seafood on two non-consecutive days of dietary recall. Dietary data were obtained from one dietary recall per individual.ResultsNon-meat eaters had substantially greater HEI-2010 and AHEI-2010 scores than meat eaters (P<0·05). Among non-meat eaters, mean consumption across HEI-2010 quintiles demonstrated different (P<0·05) amounts of empty calories and unsaturated:saturated fatty acids. Mean consumption across AHEI-2010 quintiles demonstrated different (P<0·05) amounts of nuts and legumes, vegetables and PUFA.ConclusionsPublic health messages targeted at vegetarians and others who may choose to eat meat-free on certain days should emphasize decreased consumption of empty calories, and increased consumption of nuts and legumes, PUFA and vegetables, as a way to improve overall dietary quality.
Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
Authors: Lee Jonghyeob , Snyder Emily R. , Liu Yinghua , Gu Xueying , Wang Jing , Flowers Brittany M. , Kim Yoo Jung , Park Sangbin , Szot Gregory L. , Hruban Ralph H. , Longacre Teri A. , Kim Seung K. 
Published: March 2017

AbstractDevelopment of systems that reconstitute hallmark features of human pancreatic intraepithelial neoplasia (PanINs), the precursor to pancreatic ductal adenocarcinoma, could generate new strategies for early diagnosis and intervention. However, human cell-based PanIN models with defined mutations are unavailable. Here, we report that genetic modification of primary human pancreatic cells leads to development of lesions resembling native human PanINs. Primary human pancreas duct cells harbouring oncogenic KRAS and induced mutations in CDKN2A, SMAD4 and TP53 expand in vitro as epithelial spheres. After pancreatic transplantation, mutant clones form lesions histologically similar to native PanINs, including prominent stromal responses. Gene expression profiling reveals molecular similarities of mutant clones with native PanINs, and identifies potential PanIN biomarker candidates including Neuromedin U, a circulating peptide hormone. Prospective reconstitution of human PanIN development from primary cells provides experimental opportunities to investigate pancreas cancer development, progression and early-stage detection.
A phenol-enriched cuticle is ancestral to lignin evolution in land plants
Authors: Renault Hugues , Alber Annette , Horst Nelly A. , Basilio Lopes Alexandra , Fich Eric A. , Kriegshauser Lucie , Wiedemann Gertrud , Ullmann Pascaline , Herrgott Laurence , Erhardt Mathieu , Pineau Emmanuelle , Ehlting Jürgen , Schmitt Martine , Rose Jocelyn K. C. , Reski Ralf , Werck-Reichhart Danièle 
Published: March 2017

AbstractLignin, one of the most abundant biopolymers on Earth, derives from the plant phenolic metabolism. It appeared upon terrestrialization and is thought critical for plant colonization of land. Early diverging land plants do not form lignin, but already have elements of its biosynthetic machinery. Here we delete in a moss the P450 oxygenase that defines the entry point in angiosperm lignin metabolism, and find that its pre-lignin pathway is essential for development. This pathway does not involve biochemical regulation via shikimate coupling, but instead is coupled with ascorbate catabolism, and controls the synthesis of the moss cuticle, which prevents desiccation and organ fusion. These cuticles share common features with lignin, cutin and suberin, and may represent the extant representative of a common ancestor. Our results demonstrate a critical role for the ancestral phenolic metabolism in moss erect growth and cuticle permeability, consistent with importance in plant adaptation to terrestrial conditions.
Fundamental Limitation on Cooling under Classical Noise
Authors: Jing Jun , Chhajlany Ravindra W. , Wu Lian-Ao 
Published: March 2017

AbstractWe prove a general theorem that the action of arbitrary classical noise or random unitary channels can not increase the maximum population of any eigenstate of an open quantum system, assuming initial system-environment factorization. Such factorization is the conventional starting point for descriptions of open system dynamics. In particular, our theorem implies that a system can not be ideally cooled down unless it is initially prepared as a pure state. The resultant inequality rigorously constrains the possibility of cooling the system solely through temporal manipulation, i.e., dynamical control over the system Hamiltonian without resorting to measurement based cooling methods. It is a substantial generalization of the no-go theorem claiming that the exact ground state cooling is forbidden given initial system-thermal bath factorization, while here we prove even cooling is impossible under classical noise.
Brain-derived neurotrophic factor promotes human granulosa-like tumor cell steroidogenesis and proliferation by activating the FSH receptor-mediated signaling pathway
Authors: Xie Min , Li Meiling , Zhou Ji , Ding Xiaomeng , Shao Yidan , Jing Jun , Liu Yuxiu , Yao Bing 
Published: March 2017

AbstractBrain-derived neurotrophic factor (BDNF) and FSH receptor (FSHR) are expressed in ovarian granulosa cells, and play important roles in regulating follicle growth and oocyte maturation. Studies have linked the BDNF-associated signaling pathway to FSHR mRNA expression in the regulation of follicle development, but the mechanisms remain unknown. In the current study, we found that BDNF stimulated the secretion of estradiol and progesterone, and increased the proliferation of KGN cells (human granulosa-like tumor cell line). BDNF treatment also increased phosphorylated and ubiquitinated FSHR, and activated cAMP/PKA/CREB signaling pathway. Moreover, inhibition of BDNF expression by siRNA markedly reduced the estradiol secretion and down-regulated FSHR, aromatase and phosphorylated CREB; meanwhile, FSH treatment partly alleviated the effects of BDNF siRNA on KGN cells. These findings suggested that BDNF modulates graunlosa cell functions and the action probably mediated by FSHR-coupled signaling pathway, to affect aromatase-mediated steroidogenesis. These results provide an alternative target to optimize ovarian granulosa cell function.
Temporal and structural evolution of the Early Palæogene rocks of the Seychelles microcontinent
Authors: Shellnutt J. Gregory , Yeh Meng-Wan , Suga Kenshi , Lee Tung-Yi , Lee Hao-Yang , Lin Te-Hsien 
Published: March 2017

AbstractThe Early Palæogene Silhouette/North Island volcano-plutonic complex was emplaced during the rifting of the Seychelles microcontinent from western India. The complex is thought to have been emplaced during magnetochron C28n. However, the magnetic polarities of the rocks are almost entirely reversed and inconsistent with a normal polarity. In this study we present new in situ zircon U/Pb geochronology of the different intrusive facies of the Silhouette/North Island complex in order to address the timing of emplacement and the apparent magnetic polarity dichotomy. The rocks from Silhouette yielded weighted mean 206Pb/238U ages from 62.4 ± 0.9 Ma to 63.1 ± 0.9 Ma whereas the rocks from North Island yielded slightly younger mean ages between 60.6 ± 0.7 Ma to 61.0 ± 0.8 Ma. The secular latitudinal variation from Silhouette to North Island is consistent with the anticlockwise rotation of the Seychelles microcontinent and the measured polarities. The rocks from Silhouette were emplaced across a polarity cycle (C26r-C27n-C27r) and the rocks from North Island were emplaced entirely within a magnetic reversal (C26r). Moreover, the rocks from North Island and those from the conjugate margin of India are contemporaneous and together mark the culmination of rift-related magmatism.
Hyper- and hypo- nutrition studies of the hepatic transcriptome and epigenome suggest that PPARα regulates anaerobic glycolysis
Authors: Soltis Anthony R. , Motola Shmulik , Vernia Santiago , Ng Christopher W. , Kennedy Norman J. , Dalin Simona , Matthews Bryan J. , Davis Roger J. , Fraenkel Ernest 
Published: March 2017

AbstractDiet plays a crucial role in shaping human health and disease. Diets promoting obesity and insulin resistance can lead to severe metabolic diseases, while calorie-restricted (CR) diets can improve health and extend lifespan. In this work, we fed mice either a chow diet (CD), a 16 week high-fat diet (HFD), or a CR diet to compare and contrast the effects of these diets on mouse liver biology. We collected transcriptomic and epigenomic datasets from these mice using RNA-Seq and DNase-Seq. We found that both CR and HFD induce extensive transcriptional changes, in some cases altering the same genes in the same direction. We used our epigenomic data to infer transcriptional regulatory proteins bound near these genes that likely influence their expression levels. In particular, we found evidence for critical roles played by PPARα and RXRα. We used ChIP-Seq to profile the binding locations for these factors in HFD and CR livers. We found extensive binding of PPARα near genes involved in glycolysis/gluconeogenesis and uncovered a role for this factor in regulating anaerobic glycolysis. Overall, we generated extensive transcriptional and epigenomic datasets from livers of mice fed these diets and uncovered new functions and gene targets for PPARα.
A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification
Authors: Arebro Julia , Ekstedt Sandra , Hjalmarsson Eric , Winqvist Ola , Kumlien Georén Susanna , Cardell Lars-Olaf 
Published: March 2017

AbstractA re-examination of former concepts is required to meet today’s medical challenges in allergic rhinitis. Previously, neutrophils have been treated as a relatively homogenous cell population found in the nose both when the patient is suffering at the height of the allergic season as well as when the patient report no symptoms. However, new data indicates that neutrophils can be divided into different subsets with diverse roles in inflammation. We showed increased levels of neutrophils in peripheral blood, nasal biopsies and nasal lavage fluid (NAL) from allergic patients during the pollen season compared to healthy controls. A closer examination revealed that the activated subset of neutrophils, CD16high CD62Ldim, outweighed the normal form CD16high CD62Lhigh in nasal tissue among these patients. This skewed distribution was not seen in controls. The normal subset prevailed in peripheral blood from patients as well as controls, whereas CD16high CD62Ldim and CD16dim CD62Ldim subsets, the latter considered “end state” neutrophils before apoptosis, were elevated in NAL. Functional in vitro experiments revealed that activated neutrophils exhibit a T cell priming capacity and an ability to enhance eosinophil migration. Activated neutrophils may thus contribute to allergic inflammation seen in allergic rhinitis by priming T cells and attracting eosinophils.
Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease
Authors: Wu Chia-Lin , Su Tzu-Cheng , Chang Chia-Chu , Kor Chew-Teng , Chang Chung-Ho , Yang Tao-Hsiang , Chiu Ping-Fang , Tarng Der-Cherng 
Published: March 2017

AbstractPeroxiredoxin 3 (PRX3) is a mitochondrial antioxidant that regulates apoptosis in various cancers. However, whether tubular PRX3 predicts recovery of renal function following acute kidney injury (AKI) remains unknown. This retrospective cohort study included 54 hospitalized patients who had AKI with biopsy-proven acute tubular necrosis (ATN). The study endpoint was renal function recovery within 6 months. Of the 54 enrolled patients, 25 (46.3%) had pre-existing chronic kidney disease (CKD) and 33 (61%) recovered renal function. Tubular PRX3 expression was higher in patients with ATN than in those without renal function recovery. The level of tubular but not glomerular PRX3 expression predicted renal function recovery from AKI (AUROC = 0.76). In multivariate Cox regression analysis, high PRX3 expression was independently associated with a higher probability of renal function recovery (adjusted hazard ratio = 8.99; 95% CI 1.13–71.52, P = 0.04). Furthermore, the discriminative ability of the clinical model for AKI recovery was improved by adding tubular PRX3. High tubular PRX3 expression was associated with a higher probability of renal function recovery from ATN. Therefore, tubular PRX3 in combination with conventional predictors can further improve recovery prediction and may help with risk stratification in AKI patients with pre-existing CKD.
Effective Construction of High-quality Iron Oxy-hydroxides and Co-doped Iron Oxy-hydroxides Nanostructures: Towards the Promising Oxygen Evolution Reaction Application
Authors: Zhang Xinyu , An Li , Yin Jie , Xi Pinxian , Zheng Zhiping , Du Yaping 
Published: March 2017

AbstractRational design of high efficient and low cost electrocatalysts for oxygen evolution reaction (OER) plays an important role in water splitting. Herein, a general gelatin-assisted wet chemistry method is employed to fabricate well-defined iron oxy-hydroxides and transitional metal doped iron oxy-hydroxides nanomaterials, which show good catalytic performances for OER. Specifically, the Co-doped iron oxy-hydroxides (Co0.54Fe0.46OOH) show the excellent electrocatalytic performance for OER with an onset potential of 1.52 V, tafel slope of 47 mV/dec and outstanding stability. The ultrahigh oxygen evolution activity and strong durability, with superior performance in comparison to the pure iron oxy-hydroxide (FeOOH) catalysts, originate from the branch structure of Co0.54Fe0.46OOH on its surface so as to provide many active edge sites, enhanced mass/charge transport capability, easy release oxygen gas bubbles, and strong structural stability, which are advantageous for OER. Meanwhile, Co-doping in FeOOH nanostructures constitutes a desirable four-electron pathway for reversible oxygen evolution and reduction, which is potentially useful for rechargeable metal−air batteries, regenerative fuel cells, and other important clean energy devices. This work may provide a new insight into constructing the promising water oxidation catalysts for practical clean energy application.