bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facility‐level variation in diabetes and blood pressure control in patients with diabetes: Findings from the Veterans Affairs national database
Authors: Rehman Hasan , Akeroyd Julia M. , Ramsey David , Ahmed Sarah T. , Merchant Anwar T. , Navaneethan Sankar D. , Petersen Laura A. , Virani Salim S. 
Published: August 2017

BackgroundIntensive glycemic and blood pressure (BP) control in diabetic patients is associated with improved cardiovascular outcomes.HypothesisWe hypothesized that there is suboptimal glycemic and BP control with significant facility‐level variation in patients with diabetes.MethodsWe identified patients with diabetes receiving care in 130 facilities in the Veterans Affairs Health Care System. We assessed facility‐level rates of glycemic (hemoglobin [Hb]A1c <7%), BP (BP <140/90 mmHg), and combined glycemic and BP control (HbA1c <7% and BP <140/90 mmHg), and their facility‐level variation in using median rate ratios (MRR).ResultsAmong 1 103 302 patients with diabetes, 50.2% participants had an HbA1c <7%, 77.5% had a BP <140/90 mmHg, and 39.8% had both, HbA1c <7% and BP <140/90 mmHg. Median facility‐level rates were 50.3% (interquartile range [IQR], 47.9%–52.4%) for glycemic control, 78.4% (IQR, 75.2%–80.0%) for BP control, and 39.9% (IQR, 38.14%–42.34%) for combined glycemic and BP control. Unadjusted MRR for glycemic control was 1.61 (95% confidence interval [CI]: 1.51‐1.70) which decreased to 1.16 (95% CI: 1.14‐1.19) after adjusting for patient and facility‐level variables, indicating a 16% variation in glycemic control between 2 identical patients receiving care at 2 random facilities. Unadjusted MRR for BP control was 1.49 (95% CI: 1.41‐1.56), which decreased to 1.25 (95% CI: 1.21‐1.28), whereas unadjusted MRR for combined glycemic and BP control was 1.59 (95% CI: 1.50‐1.68), which decreased to 1.15 (95% CI: 1.13‐1.17) after adjustment.ConclusionsFacility‐level rates for BP control and glycemic control remain low with significant facility‐level variation. Much of this is explained by patient and facility‐level variables although 16%, 25%, and 15% variation in glycemic, BP, and combined glycemic and BP control remains unexplained.
Long‐term weight loss after colorectal cancer diagnosis is associated with lower survival: The Colon Cancer Family Registry
Authors: Kocarnik Jonathan M. , Hua Xinwei , Hardikar Sheetal , Robinson Jamaica , Lindor Noralane M. , Win Aung Ko , Hopper John L. , Figueiredo Jane C. , Potter John D. , Campbell Peter T. , Gallinger Steven , Cotterchio Michelle , Adams Scott V. , Cohen Stacey A. , Phipps Amanda I. , Newcomb Polly A. 
Published: August 2017

BACKGROUNDBody weight is associated with colorectal cancer (CRC) risk and survival, but to the authors' knowledge, the impact of long‐term postdiagnostic weight change is unclear. Herein, the authors investigated whether weight change over the 5 years after a diagnosis of CRC is associated with survival.METHODSCRC cases diagnosed from 1997 to 2008 were identified through 4 population‐based cancer registry sites. Participants enrolled within 2 years of diagnosis and reported their height and weight 2 years prior. Follow‐up questionnaires were administered approximately 5 years after diagnosis. Associations between change in weight (in kg) or body mass index (BMI) with overall and CRC‐specific survival were estimated using Cox regression analysis adjusted for age, sex, American Joint Committee on Cancer stage of disease, baseline BMI, nonsteroidal anti‐inflammatory drug use, smoking, time between diagnosis and enrollment, and study site.RESULTSAt the 5‐year postdiagnostic survey, 2049 participants reported higher (53%; median plus 5 kg), unchanged (12%), or lower (35%; median ‐4 kg) weight. Over a median of 5.1 years of subsequent follow‐up (range, 0.3‐9.9 years), 344 participants died (91 of CRC). Long‐term weight loss (per 5 kg) was found to be associated with poorer overall survival (hazard ratio, 1.13; 95% confidence interval, 1.07‐1.21) and CRC‐specific survival (hazard ratio, 1.25; 95% confidence interval, 1.13‐1.39). Significantly lower survival was similarly observed for relative weight loss (>5% vs ≤5% change), BMI reduction (per 1 unit), or BMI category change (overweight to normal vs remaining overweight).CONCLUSIONSWeight loss 5 years after a diagnosis of CRC was found to be significantly associated with decreased long‐term survival, suggesting the importance of avoiding weight loss in survivors of CRC. Future research should attempt to further evaluate this association, accounting for whether this weight change was intentional or represents a marker of declining health. Cancer 2017;123:4701‐4708. © 2017 American Cancer Society.
Phase 1 dose escalation multicenter trial of pracinostat alone and in combination with azacitidine in patients with advanced hematologic malignancies
Authors: Abaza Yasmin M. , Kadia Tapan M. , Jabbour Elias J. , Konopleva Marina Y. , Borthakur Gautam , Ferrajoli Alessandra , Estrov Zeev , Wierda William G. , Alfonso Ana , Chong Toh Han , Chuah Charles , Koh Liang‐Piu , Goh Boon‐Cher , Chang Julie E. , Durkes Daniel E. , Foudray Maria Cielo , Kantarjian Hagop M. , Dong Xiao Qin , Garcia‐Manero Guillermo 
Published: August 2017

BACKGROUNDPracinostat is a potent histone deacetylase inhibitor with antitumor activity in both solid tumor and acute myeloid leukemia (AML) cell lines. Pracinostat is reported to have modest clinical activity in patients with advanced solid tumors. Given the higher preclinical sensitivity of hematologic malignancies to pracinostat, the authors conducted a phase 1 study to assess the safety, maximum tolerated dose, recommended phase 2 dose, efficacy, pharmacokinetics, and pharmacodynamics of pracinostat in patients with advanced hematological malignancies.METHODSPracinostat was administered orally 3 times a week for 3 weeks on a 28‐day cycle. Patients were assigned to 7 dose levels using a 3 + 3 dose escalation design.RESULTSA total of 44 patients were enrolled, 25 of whom had AML and 14 of whom had myelodysplastic syndrome. The maximum tolerated dose was 120 mg and the recommended phase 2 dose was 60 mg. Two patients with AML achieved a response: 1 complete remission (CR) and 1 complete cytogenetic response. Despite a dose‐dependent increase in the plasma concentration of pracinostat, a similar increase in histone acetylation was not observed. As an extension, 10 additional patients with myelodysplastic syndrome were enrolled to assess the safety and efficacy of pracinostat in combination with azacitidine. Six patients achieved a CR and 3 achieved a CR without platelet recovery with no added toxicity.CONCLUSIONSThe results of the current study demonstrate that pracinostat is safe, with modest single‐agent activity in patients with hematological malignancies. Cancer 2017;123:4851‐9. © 2017 American Cancer Society.
Secure communication scheme analysis via complex networks
Authors: Ding Yong , Xiong Ning , He En , Li Kezan 
Published: August 2017

SummaryRecently, some existing works have introduced novel way to construct complex networks from embedded time series, which provides new sights into the organizational properties of the time series in phase space. In this paper, we attempt to answer the fundamental question of “how much information regarding the dynamic property of the original time series can be extracted from these networks.” To this end, we propose a new method for reconstructing time series from the networks. We compare the reconstructed time series from these networks and that from the recurrence plot. We find that these networks contain topological information of the embedded time series to a certain degree. In general, they are more powerful than the recurrence plot method in the reconstruction of embedded time series. In addition, we study a new generalized projective synchronization (GPS) of coupled complex dynamical networks with different sizes via feedback control and impulsive control. Based on the stability analysis of impulsive system, a network synchronization criterion is established. These works may find potential application for secure communication via networks.
Photocatalytic Conversion of CO2 to CO by a Copper(II) Quaterpyridine Complex
Authors: Guo Zhenguo , Yu Fei , Yang Ying , Leung Chi‐Fai , Ng Siu‐Mui , Ko Chi‐Chiu , Cometto Claudio , Lau Tai‐Chu , Robert Marc 
Published: August 2017

AbstractThe invention of efficient systems for the photocatalytic reduction of CO2 comprising earth‐abundant metal catalysts is a promising approach for the production of solar fuels. One bottleneck is to design highly selective and robust molecular complexes that are able to transform the CO2 gas. The CuII quaterpyridine complex [Cu(qpy)]2+ (1) is found to be a highly efficient and selective catalyst for visible‐light driven CO2 reduction in CH3CN using [Ru(bpy)3]2+ (bpy: bipyridine) as photosensitizer and BIH/TEOA (1,3‐dimethyl‐2‐phenyl‐2,3‐dihydro‐1H‐benzo[d]imidazole/triethanolamine) as sacrificial reductant. The photocatalytic reaction is greatly enhanced by the presence of H2O (1–4 % v/v), and a turnover number of >12 400 for CO production can be achieved with 97 % selectivity, which is among the highest of molecular 3d CO2 reduction catalysts. Results from Hg poisoning and dynamic light scattering experiments suggest that this photocatalyst is homogenous. To the best of our knowledge, 1 is the first example of molecular Cu‐based catalyst for the photoreduction of CO2.
Use of oral antidiabetic drugs in the treatment of maturity‐onset diabetes of the young: A mini review
Authors: Brunerova Ludmila , Rahelić Dario , Ceriello Antonio , Broz Jan 
Published: August 2017

SummaryMODY (maturity‐onset diabetes of the young) is a genetically linked group of clinically heterogeneous subtypes of diabetes. Roughly 5% of people with diabetes mellitus diagnosed prior to age 45 have MODY diabetes. Most of them have been erroneously diagnosed as patients with either type 1 or type 2 diabetes and, as a result, have been improperly treated. Genetic identification of MODY diabetes and its subtypes allows proper treatment and enables clinicians to switch many patients to oral antidiabetic agents, mainly sulphonylureas. However, some new classes of oral antidiabetic drugs have also been tested and found to be effective in MODY patients. We have searched for research articles and case reports written in full‐text English or with an English abstract, using the following keywords: MODY and oral antidiabetic* in the databases Cochrane Library, PubMed, and Science Direct. Therapeutic options using currently standardized oral antidiabetic drugs (mainly sulphonylureas), as well as more experimental treatment with other classes of oral antidiabetic drugs in different types of MODY, are discussed, with special focus on the therapy of the most common MODY subtypes, including specific conditions such as pregnancy. This review article summarizes the currently available information about oral antidiabetic treatment of patients with MODY diabetes.
A Novel Method for Extracting Steryl Glucosides From Soy Lecithin
Authors: Xie Meizhen , Zhao Hong 
Published: August 2017

In this study, a novel method utilizing enzyme and involving simple solvent extraction steps, is developed to yield an extract with high content of steryl glucosides (SG) and acyl steryl glucosides (ASG) from soy lecithin – the by‐product of vegetable oil refining. Phospholipase A1 is used to convert phospholipids in soy lecithin into more hydrophilic hydrolysates, from which SG and ASG are separated by solvent extractions. A 3 × 3 full factorial design is employed to investigate the effects of two parameters (enzyme dose and reaction time) on three responses (yield of extract, SG/ASG content of extract, and recovery of SG/ASG). There are significant enzyme dose – reaction time interaction effects on all the responses, except for yield of extract. The highest SG (including ASG) content of more than 90% in the extract is achieved at enzyme dose of 0.03 g and reaction time of 16 h, where the yield of extract obtained is 1.43%.Practical Applications: Conventionally, steryl glucosides and acyl steryl glucosides are isolated from lipid extract and purified by chromatographic methods, which result in a small amount of high purity steryl glucosides and acyl steryl glucosides, and thus is not economic to scale up. The method revealed in this study employed an enzymatic reaction followed by simple solvent extractions, and can be easily scaled up to produce high purity steryl glucosides and acyl steryl glucosides, making them more affordable for researchers. In addition, the method also presents a new application for soy lecithin or lecithin of other plant origins, whose current applications are mostly related to the main component‐phospholipids.In this study, a novel method utilizing enzyme and involving simple solvent extraction steps is developed to yield an extract with high content of steryl glucosides (SG) and acyl steryl glucosides (ASG) from soy lecithin – the by‐product of vegetable oil refining.
Hydromagnetic non‐Newtonian nanofluid transport phenomena from an isothermal vertical cone with partial slip: Aerospace nanomaterial enrobing simulation
Authors: Annasagaram Subba Rao , CH Amanulla , N Nagendra , M Surya Narayana Reddy , Bég O. Anwar 
Published: August 2017

AbstractIn this article, the combined magneto‐hydrodynamic heat, momentum, and mass (species) transfer in external boundary layer flow of Casson nanofluid from a vertical cone surface with convective conditions under an applied magnetic field is studied theoretically. The effects of Brownian motion and thermophoresis are incorporated in the model in the presence of both heat and nanoparticle mass transfer convective conditions. The governing partial differential equations (PDEs) are transformed into highly nonlinear, coupled, multidegree, nonsimilar PDEs consisting of the momentum, energy, and concentration equations via appropriate nonsimilarity transformations. These transformed conservation equations are solved subject to appropriate boundary conditions with a second‐order, accurate finite difference method of the implicit type. The influences of the emerging parameters, that is, magnetic parameter (M), Casson fluid parameter (β), Brownian motion parameter (Nb), thermophoresis parameter (Nt), Lewis number (Le), Prandtl number (Pr), velocity slip (Sf) and thermal slip (ST) on velocity, temperature, and nanoparticle concentration distributions is illustrated graphically and interpreted at length. Validation of solutions with a Nakamura tridiagonal method has been included. The study is relevant to enrobing processes for electrically conductive nanomaterials, of potential use in aerospace and other industries.
A novel method used to study growth of ash deposition and in situ measurement of effective thermal conductivity of ash deposit
Authors: Zhimin Zheng , Hui Wang , Yongtie Cai , Xing Wei , Shaohua Wu 
Published: August 2017

AbstractAsh deposition always brings boilers some trouble due to fouling or slagging. In this paper, a completely controlled system was developed to study the growth of ash deposit. A novel sampling probe was designed to online measure the heat flux through ash deposit. Additionally, the thickness of ash deposit can be obtained by an online figure collecting system. The results of this research showed that as the thickness of ash deposit increased, the heat flux decreased. It was also found that at the initial stage of ash deposition when the thickness of ash deposit is approximately 1 mm, the heat flux through ash deposit had a sharp reduction. An effective method was attempted to situ measure the effective thermal conductivity of the ash deposit in the simulated combustion flue gas. It was found that temperature of the ash deposit layer had no obvious effect on its value. It was concluded that the structure of ash deposit had no obvious change in a short deposition time of 30 min with varied surface temperatures of the probe head between 400 °C and 600 °C.
One‐dimensional transient heat conduction in a bilayer finite slab: A case study in the printing process
Authors: Borah Uditya , Baruah Dipal 
Published: August 2017

AbstractIn this work, a typical case of heat distribution is examined during a paper printing process, based on one‐dimensional transient heat conduction in two‐layer finite slabs with an insulated free surface, and a constant temperature free surface. Analytical solutions were obtained in non‐dimensional form. Various examples of applying these solutions are presented. The accuracy of the solutions, with respect to time, is analyzed considering the eigenvalues of their infinite solutions. It is observed that the larger the number of eigenvalues in consideration, the better the accuracy of the solutions. The model related to a two‐layer slab describes the simplified case in which all heat transfer occurs only by conduction. The solutions obtained are finally compared with the solutions for heat conduction in two semi‐infinite solids. The comparison between the two solutions shows that results are in good agreement only during short time scales. The heat distribution study is expected to be helpful in knowing the effectiveness of various mediums to be used as the reciever during the printing process; however, there is scope for development of more robust models.
A numerical investigation on the heat and fluid flow of various nanofluids on a stretching sheet
Authors: Makarem Mohammad Amin , Bakhtyari Ali , Rahimpour Mohammad Reza 
Published: August 2017

AbstractFollowing the necessity of investigating fluid flow and heat transfer in the stretching sheet problem and effect of nanofluids on them, performance of various nanofluids were investigated in the present study. Three base fluids (deionized water, ethylene glycol, and engine oil) in combination with 18 nanoparticles (metals and their oxides) were investigated. While experimental methods are preferable, a mathematical model was developed and solved by applying differential quadrature method due to lack of such experimental data. With the results obtained in the real dimensions, the error caused by the cancellation of the viscosity effect due to the dimensionless variables was omitted. Effects of magnetic field and volume fraction of nanoparticle on the fluid flow and heat transfer characteristics were investigated. Highest heat transfer rate as well as small amounts of shear stress was obtained for deionized water–Al and deionized water–Mg nanofluids. Increasing volume fraction of nanoparticle was observed to increase both heat transfer and shear stress rates, while presence of a magnetic field caused an increase in shear stress and decrease in heat transfer rate.
Nonsimilarity boundary layer flow of copper–water nanofluid near stagnation point in a porous medium
Authors: Shen Ming , Dai Yu , Chen Hui 
Published: August 2017

AbstractThe effects of nanoparticle shape are first introduced to study the nonsimilar solutions of stagnation point boundary layer flow of water–copper nanofluid saturated in a porous medium. Two cases of solid matrix of porous medium, including glass balls and aluminum foam, are considered. By using a new empirical correlation for the heat capacitance, thermal conductivity, and thermal diffusivity of the nanofluid saturated in a porous medium, the governing equations of the problem are constructed and reduced by dimensionless variables and nonsimilar transformations, and the homotopy analysis method is adopted to solve the partial differential equations. The results indicate that the heat transfer is significantly enhanced with the increase of permeability of the porous medium on the surface of the stagnation point boundary layer flow. In addition, it is found that the empirical shape of the nanoparticle has an impact on the heat transfer.
Performance of an allele‐level multi‐locus HLA genotype imputation tool in hematopoietic stem cell donors from Quebec
Authors: Ferradji Abdelhakim , D'Souza Yasmin , Saw Chee Loong , Oualkacha Karim , Richard Lucie , Sapir‐Pichhadze Ruth 
Published: August 2017

AbstractIntroductionDonor‐recipient HLA compatibility is an important determinant of transplant outcomes. Allele‐group to allele‐level imputations help assign HLA genotypes when allele‐level genotypes are not available during donor selection.MethodsWe evaluated the performance of HaploStats, an allele‐level multi‐locus HLA genotype imputation tool from the National Marrow Donor Program, in a cross‐sectional study including hematopoietic stem cell donors (HSCD) from Quebec, Canada. A total of 144 self‐identified Caucasian HSCD genotyped at the allele‐group and allele‐level for HLA‐A, ‐B, ‐C, ‐DRB1, and ‐DQB1 loci were studied. We compared allele‐level genotypes imputed by HaploStats to those obtained by the reference standard, sequenced‐based typing (SBT).ResultsImputation performance, determined by allele‐level genotype recall (fraction of matching imputed and sequenced genotypes) was 97%, 96%, 95%, 84%, and 81% for HLA‐A, ‐B, ‐C, ‐DRB1, and ‐DQB1 loci, respectively. Our sample deviated from Hardy‐Weinberg equilibrium only at the HLA‐DRB1 locus. Residual ambiguity, determined by typing resolution scores (TRS), was greatest for HLA class II loci (average TRS 0.65 and 0.80 for DRB1 and DQB1, respectively). In contrast, average TRS of 0.88, 0.84, and 0.92 was observed for HLA‐A, ‐B, and ‐C, respectively.ConclusionsHLA allele imputation from ambiguous genotypes demonstrate satisfactory prediction accuracy for HLA class I but modest prediction accuracy for HLA class II loci in self‐identified Caucasian HSCD from Quebec. While consideration of high‐resolution allele and haplotype frequencies in the Quebec population may improve the performance of available allele‐level multi‐locus genotype imputation tools in Quebec, this study suggests that genotyping at the first two field level should be conducted whenever possible.
Honeysuckle flowers extract loaded Bombyx mori silk fibroin films for inducing apoptosis of HeLa cells
Authors: Li Chenlin , Yang Mingying , Zhu Liangjun , Zhu Yongqiang 
Published: August 2017

AbstractThis study aimed to prepare silk fibroin (SF) films loaded with honeysuckle flowers extract (HFE) for inducing apoptosis of HeLa cells. We mixed solution of SF and HFE by air‐drying for preparing the honeysuckle flowers extract loaded silk fibroin (SFH) films. The physical properties including morphologies, contact angle, roughness, and Z range were characterized. MTS assay and fluorescence micrographs proved that SFH films inhibited the proliferation rate of HeLa cells due to induction of HFE into SF films. Furthermore, cell apoptosis assay and cell cycle analysis confirmed that the apoptosis of HeLa cells resulted from SFH films. Therefore, SFH films designed in our study might be a promising candidate material for cancer therapy.
Women's Empowerment in Agriculture and Household‐Level Health in Northern Ghana: A Capability Approach
Authors: Zereyesus Yacob Abrehe 
Published: August 2017

AbstractThe effect of women's empowerment on household's health status is examined for households in northern Ghana with a Multiple Indicators Multiple Causes model by using a capability approach. Household's latent health is represented by the number of stunted children, number of wasted children and number of underweight women. Demographic and socioeconomic variables are used as covariates. Results confirmed the existence of underlying latent physical health. Results showed a positive effect of women's empowerment on household's health status, with implications on its intrahousehold effect. Covariates such as father's literacy, the proportion of dependents and health expenditures are significantly associated with the health of a household. Copyright © 2017 John Wiley & Sons, Ltd.