bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Outcomes and Failure Rates of Osteochondral Allograft Transplantation in the Knee: A Systematic Review
Authors: Familiari Filippo , Cinque Mark E. , Chahla Jorge , Godin Jonathan A. , Olesen Morten Lykke , Moatshe Gilbert , LaPrade Robert F. 
Published: October 2017

Background: Cartilage lesions are a significant cause of morbidity and impaired knee function; however, cartilage repair procedures have failed to reproduce native cartilage to date. Thus, osteochondral allograft (OCA) transplantation represents a 1-step procedure to repair large chondral defects without the donor site morbidity of osteochondral autograft transplantation. Purpose: To perform a systematic review of clinical outcomes and failure rates after OCA transplantation in the knee at a minimum mean 2 years’ follow-up. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of the literature regarding the existing evidence for clinical outcomes and failure rates of OCA transplantation in the knee joint was performed using the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, PubMed, and MEDLINE from studies published between 1980 and 2017. Inclusion criteria were as follows: clinical outcomes and failure rates of OCAs for the treatment of chondral defects in the knee joint, English language, mean follow-up of 2 years and minimum follow-up of 18 months, minimum study size of 20 patients, and human studies. The methodological quality of each study was assessed using a modified version of the Coleman methodology score. Results: The systematic search identified 19 studies with a total of 1036 patients. The mean 5-year survival rate across the studies included in this review was 86.7% (range, 64.1%-100.0%), while the mean 10-year survival rate was 78.7% (range, 39.0%-93.0%). The mean survival rate was 72.8% at 15 years (range, 55.8%-84.0%) and 67.5% at 20 years (range, 66.0%-69.0%). The weighted mean patient age was 31.5 years (range, 10-82 years), and the weighted mean follow-up was 8.7 years (range, 2-32 years). The following outcome measures showed significant improvement from preoperatively to postoperatively: d’Aubigné-Postel, International Knee Documentation Committee, Knee Society function, and Lysholm scores. The weighted mean reoperation rate was 30.2% (range, 0%-63%). The weighted mean failure rate was 18.2% (range, 0%-31%). Of note, revision cases, patellar lesions, and bipolar lesions demonstrated worse survival rates. Conclusion: Improved patient-reported outcomes can be expected after OCA transplantation, with a survival rate of 78.7% at 10 years. Revision cases, patellar lesions, and bipolar lesions were associated with worse survival rates; therefore, utilization of the most appropriate index cartilage restoration procedure and proper patient selection are key to improving results.
Repeated measures dose-finding design with time-trend detection in the presence of correlated toxicity data
Authors: Yin Jun , Paoletti Xavier , Sargent Daniel J , Mandrekar Sumithra J 
Published: October 2017

Background: Phase I trials are designed to determine the safety, tolerability, and recommended phase 2 dose of therapeutic agents for subsequent testing. The dose-finding paradigm has thus traditionally focused on identifying the maximum tolerable dose of an agent or combination therapy under the assumption that there is a non-decreasing relationship between dose–toxicity and dose–efficacy. The dose is typically determined based on the probability of severe toxicity observed during the first treatment cycle. A novel endpoint, the total toxicity profile, was previously developed to account for the multiple toxicity types and grades experienced in the first cycle. More recently, this was extended to a repeated measures design based on the total toxicity profile to account for longitudinal toxicities over multiple treatment cycles in the absence of within-patient correlation. Methods: In this work, we propose to extend the design in the presence of within-patient correlation. Furthermore, we provide a framework to detect a toxicity time trend (toxicity increasing, decreasing, or stable) over multiple treatment cycles. We utilize a linear mixed model in the Bayesian framework, with the addition of Bayesian risk functions for decision-making in dose assignment. Results: The performance of this design was evaluated using simulation studies and real data from a phase I trial. We demonstrated that using available toxicity data from all cycles of treatment improves the accuracy of maximum tolerated dose identification and allows for the detection of a time trend. The performance is consistent regardless of the strength of the within-patient correlation. In addition, the use of a quasi-continuous total toxicity profile score significantly increased the power to detect time trends compared to when binary data only were used. Conclusion: The increased interest in molecularly targeted agents and immunotherapies in oncology necessitates innovative phase I study designs. Our proposed framework provides a tool to tackle some of the challenges presented by these novel agents, specifically through the ability to understand patterns of toxicity over time, which is important in the cases of cumulative or late toxicities.
Fleeing from Frankenstein’s monster and meeting Kafka on the way: Algorithmic decision-making in higher education
Authors: Prinsloo Paul 
Published: October 2017

In the socio-technical imaginary of higher education, algorithmic decision-making offers huge potential, but we also cannot deny the risks and ethical concerns. In fleeing from Frankenstein’s monster, there is a real possibility that we will meet Kafka on our path, and not find our way out of the maze of ethical considerations in the nexus between human and nonhuman agencies. In this conceptual article, I map seven dimensions of student surveillance on an experimental matrix of human-algorithmic interaction to consider some of the ethical implications of algorithmic decision-making in higher education. The experimental matrix of human-algorithmic decision-making uses the four tasks of ‘sensing’, ‘processing’, ‘acting’ and ‘learning’ to open up algorithmic-human agency as comprising a number of possibilities such as (1) where only humans perform the task; (2) where the task is shared between humans and algorithms; (3) where algorithms perform the task but with humans supervising; and (4) where algorithms perform the tasks with no human oversight. I use this matrix to engage with seven dimensions of how higher education institutions collect, analyse and use student data namely (1) automation; (2) visibility; (3) directionality; (4) assemblage; (5) temporality; (6) sorting; and (7) structuring. The article concludes by proposing a number of pointers to be taken into consideration when implementing algorithms in a higher education context from a position of an ethics of care.
Treatment of postaxial polydactyly with plantar plate and medial collateral ligament reconstruction after supernumerary excision: A case report
Authors: Escudero Mario I , Seebach Klaus , Parekh Selene G , Pellegrini Manuel J 
Published: October 2017

Introduction: Polydactyly is the most common congenital foot anomaly and consists of partial or complete duplication of a toe. Traditionally, surgical treatment has been amputation. There is little evidence when surgical treatment requires repairing the stabilizing structures of the metatarsophalangeal joint Objective: Assess the functional and radiologic outcomes of a case of postaxial polydactyly requiring plantar plate plate and medial collateral ligament reconstruction. Methods: A 59-year-old female presented at clinic complaining from bilateral fifth toe polydactyly and metatarsalgia. A rudimentary extra toe with bony structures poorly developed was observed in the left foot. An excision was performed on the left foot. In the right foot, a fully developed extra digit was observed with medial and downwards deviation underneath the fourth metatarsal. Results: Medial fifth-toe excision, plantar plate repair and medial collateral ligament reconstruction were performed due to malformation and widening of the distal surface of the plantar plate. Patient satisfaction and adequate functional status were observed at one-year follow-up. Conclusion: The plantar plate is the principal stabilizer of the MTP joint; therefore its reconstruction is of paramount importance for forefoot biomechanics.
How Accurate Is Clinical Evaluation in Hindfoot Coronal Alignment?
Authors: Slullitel Gastón , Álvarez Victoria , Lopez Valeria , Calvi Juan Pablo , Calvo Ana Belén 
Published: October 2017

Background: Hindfoot coronal alignment is an important factor in the assessment of patients with many different foot and ankle complaints. A number of clinical and radiographic techniques have been described to measure hindfoot coronal alignment, but none of them are widely accepted. The purpose of the present study was to assess the correlation between clinical and radiographic hindfoot alignment measures and to evaluate the reproducibility of each. Methods: We evaluated 85 patients with foot and/or ankle symptoms. Hindfoot clinical alignment was measured from photographs. Each patient was placed at a distance of 1 m from the observer, with both feet placed parallel. Four photographs were taken, at a height of 40 cm: a posterior view of both lower limbs including knees, a posterior view focalized on the studied hindfoot, an anterior view of the foot, and the last view of the medial aspect of the foot. Radiographic alignment was quantified on long axial view radiographs. Patients were lying over the film cassette with a focus distance of 1 m and the beam pointed to the ankle joint. The inclination angle of the beam was 45 degrees to the floor. Measurements were independently made by 2 observers, who were asked to classify pictures into 3 categories: varus, neutral, and valgus. Radiographic measurements were made using the angle measurement tool on the radiograph viewer. The intraclass correlation coefficients (ICCs) and the 95% confidence interval (CI) of the ICC were used to quantify the inter- and intraobserver reliability for clinical assessment. Radiographic parameters were correlated by calculating the Pearson correlation coefficient (r). Results: The intraobserver ICC for clinical analysis was good for both observers, while the interobserver ICC was moderate for both measurements. Regarding radiographic assessment, there was significant intra- and interobserver reliability. The correlation between both methods was weak for both observers. Conclusions: We found only weak intra- and interobserver correlations between the clinical and radiographic assessment of hindfoot coronal alignment. It is therefore necessary to complement the clinical evaluation of hindfoot alignment with an objective measurement method such as a long axial view radiograph. Further studies comparing different measurement methods need to be performed to establish the most objective evaluation. Level of Evidence: Level III, diagnostic study.
Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model
Authors: Menzel Mandy , Akbarshahi Hamid , Mahmutovic Persson Irma , Puthia Manoj , Bjermer Leif , Uller Lena 
Published: October 2017

Rhinovirus infections are common triggers of asthma exacerbations. Viruses can activate the inflammasome, resulting in processing and activation of caspase-1. This recruitment triggers production of interleukin (IL)-1β and IL-18, which have been implicated in asthma. Elucidating the involvement of the inflammasome and its compartments, such as caspase-1, in asthma exacerbations is warranted.Gene expression of caspase-1 was measured in rhinovirus-infected primary bronchial epithelial cells of asthmatic and healthy donors 24 h post-infection. In anin vivoexacerbation experiment C57BL/6 wild-type and caspase-1-/-mice were challenged with house dust mite followed by exposures to the viral mimic poly(I:C). General lung inflammatory parameters and levels of T-helper type 2 (Th2)-upstream cytokines IL-33, thymic stromal lymphopoietin (TSLP) and IL-25 were assessed.Caspase-1 expression was elevated after rhinoviral infection exclusively in bronchial epithelial cells from asthmatics. In a translational mouse model of asthma exacerbation effects of caspase-1 on airway inflammation and Th2-upstream cytokines were explored. Caspase-1 deficient mice exhibited no alterations of general lung inflammatory parameters, but showed markedly reduced eosinophilia. Furthermore, the Th2-upstream cytokines IL-33, TSLP and IL-25 were reduced at exacerbation in mice lacking caspase-1.Rhinovirus infection increases bronchial epithelial caspase-1 in asthma. Caspase-1 may induce production of lung Th2-upstream cytokines and eosinophilia at exacerbations. Further targeting of caspase-1 signalling is warranted to explore its role in asthma exacerbations.
Time-Resolved Resonance Raman Spectroscopy and Application to Studies on Ultrafast Protein Dynamics
Authors: Mizutani Yasuhisa 
Published: October 2017

Abstract
Protein dynamics play a fundamental role in allosteric regulation, which is vital to the function of many proteins. In many proteins, rather than a direct interaction, mutual modulation of properties such as ligand affinity at spatially separated sites is achieved through a conformational change. Conformational changes of proteins are thermally activated processes that involve intramolecular and intermolecular energy exchanges. In this account, I review the work of my team on the development and applications of ultrafast time-resolved resonance Raman spectroscopy to observe functionally important protein dynamics. We gained insights into conformational dynamics upon external stimulus and energy flow with a spatial resolution of a single amino acid residue using time-resolved visible and ultraviolet resonance Raman spectroscopy. The results have contributed to a deeper understanding of the structural nature of protein motion and the relationship of dynamics to function. I discuss the protein dynamics and allosteric mechanism in terms of the nature of the high packing density of protein structures. In addition, I present a view of the future of molecular science on proteins.
Unilateral pulmonary artery pre-operative occlusion test: technical feasibility and safety prior to pneumonectomy or pleuropneumonectomy for malignancy
Authors: Shimohira Masashi , Hashizume Takuya , Ohta Kengo , Suzuki Kazushi , Nakagawa Motoo , Ozawa Yoshiyuki , Okuda Katsuhiro , Moriyama Satoru , Nakanishi Ryoichi , Shibamoto Yuta 
Published: October 2017

Objective:
The aim of the present study was to assess the technical feasibility and safety of the unilateral pulmonary artery occlusion (UPAO) test in pre-operative evaluation of pneumonectomy or pleuropneumonectomy for lung or pleural tumours.

Methods:
The UPAO test was performed on 91 patients who were scheduled to undergo or were being considered for pneumonectomy or pleuropneumonectomy between June 2003 and July 2016. There were 74 males and 17 females, with a median age of 65 years (range, 23–80). The technical success rate, procedure time and complication rate were evaluated. Technical success was defined as completion of the UPAO test.

Results:
The diagnoses of the 91 patients were as follows: lung cancer in 63, malignant pleural mesothelioma in 21, thymoma in 5, lung metastasis in 1 and lung carcinoid in 1. The UPAO test was performed successfully on 88 out of 91 patients (technical success rate: 97%). The median procedure time was 57 min (range, 34–120). Cardiac arrest due to migration of the balloon catheter to the pulmonary trunk occurred in 1 patient (complication rate: 1.1%).

Conclusion:
The UPAO test in pre-operative evaluation of pneumonectomy or pleuropneumonectomy for lung or pleural tumours appears to be technically feasible. However, it needs to be performed with care in order to avoid severe complications.

Advances in knowledge:
The UPAO test can be safely performed and is helpful in evaluating patients for pneumonectomy or pleuropneumonectomy.
Persona non grata: A systematic review of de-roling in drama therapy
Authors: Lassken Savannagh 
Published: October 2017

Abstract
This research examines the phenomenon of de-roling in drama therapy literature with respect to its purpose and application. A systematic review of the literature indicates that the purpose of de-roling relates to the following: transitioning away from an enactment, sharing and reflecting, letting go of a character or a negatively felt sensation, setting boundaries to create distance, and integrating to learn from and amalgamate character qualities. An exploration of the five outlined purposes reveals new ways to view de-roling therapeutically.
Core self, transformations and consciousness: Transpersonal perspectives on healing and holding in Role Method and DvT
Authors: Raucher Gary 
Published: October 2017

Abstract
This article offers an appreciative examination and critique of theoretical tenets of Landy’s Role Method (RM) and Johnson’s Developmental Transformations (DvT) from the perspective of Ageless Wisdom teachings and transpersonal thought. Consciousness, viewed as a depth structure, challenges Landy’s assertion that his role system obviates the need for a core self and Johnson’s minimizing of transcendence as a resource for mitigating anxieties around ‘the instability of being’. The transpersonal construct of Higher Self is proposed as a means to extend drama therapists’ capacity to hold therapeutic space for existential or spiritual issues.
Multiple exciton generation in quantum dot-based solar cells
Authors: Goodwin Heather , Jellicoe Tom C. , Davis Nathaniel J.L.K. , Böhm Marcus L. 
Published: October 2017

Abstract
Multiple exciton generation (MEG) in quantum-confined semiconductors is the process by which multiple bound charge-carrier pairs are generated after absorption of a single high-energy photon. Such charge-carrier multiplication effects have been highlighted as particularly beneficial for solar cells where they have the potential to increase the photocurrent significantly. Indeed, recent research efforts have proved that more than one charge-carrier pair per incident solar photon can be extracted in photovoltaic devices incorporating quantum-confined semiconductors. While these proof-of-concept applications underline the potential of MEG in solar cells, the impact of the carrier multiplication effect on the device performance remains rather low. This review covers recent advancements in the understanding and application of MEG as a photocurrent-enhancing mechanism in quantum dot-based photovoltaics.
Electrospun fibers in regenerative tissue engineering and drug delivery
Authors: Nagarajan Sakthivel , Pochat-Bohatier Céline , Balme Sébastien , Miele Philippe , Kalkura S. Narayana , Bechelany Mikhael 
Published: October 2017

Abstract
Electrospinning is a versatile technique to produce micron or nano sized fibers using synthetic or bio polymers. The unique structural characteristic of the electrospun mats (ESM) which mimics extracellular matrix (ECM) found influential in regenerative tissue engineering application. ESM with different morphologies or ESM functionalizing with specific growth factors creates a favorable microenvironment for the stem cell attachment, proliferation and differentiation. Fiber size, alignment and mechanical properties affect also the cell adhesion and gene expression. Hence, the effect of ESM physical properties on stem cell differentiation for neural, bone, cartilage, ocular and heart tissue regeneration will be reviewed and summarized. Electrospun fibers having high surface area to volume ratio present several advantages for drug/biomolecule delivery. Indeed, controlling the release of drugs/biomolecules is essential for sustained delivery application. Various possibilities to control the release of hydrophilic or hydrophobic drug from the ESM and different electrospinning methods such as emulsion electrospinning and coaxial electrospinning for drug/biomolecule loading are summarized in this review.
Transition-metal complexes with oxidoborates. Synthesis and XRD characterization of [(H3NCH2CH2NH2)Zn{κ3
O,O′,O′′-B12O18(OH)6-κ1
O′′′}Zn(en)(NH2CH2CH2NH3)]·8H2O (en=1,2-diaminoethane): a neutral bimetallic zwiterionic polyborate system containing the ‘isolated’ dodecaborate(6−) anion
Authors: Altahan Mohammed A. , Beckett Michael A. , Coles Simon J. , Horton Peter N. 
Published: October 2017

Abstract
The title compound, [(H3NCH2CH2NH2)Zn{κ3
O,O′,O′′-B12O18(OH)6-κ1
O′′′}Zn(en)(NH2CH2CH2NH3)]·8H2O (en=1,2-diaminoethane) (1), was prepared as a crystalline solid in moderate yield from the reaction of B(OH)3 with [Zn(en)3][OH]2 in aqueous solution (15:1) ratio. The structure contains a neutral bimetallic complex comprised of a unusual dodecaborate(6−) anion ligating two [H3NCH2CH2NH2Zn(en)n]3+ centers in a monodentate (n=1) or tridentate (n=0) manner.
DeltaShaper: Enabling Unobservable Censorship-resistant TCP Tunneling over Videoconferencing Streams
Authors: Barradas Diogo , Santos Nuno , Rodrigues Luís 
Published: October 2017

Abstract
This paper studies the possibility of using the encrypted video channel of widely used videoconferencing applications, such as Skype, as a carrier for unobservable covert TCP/IP communications. We propose and evaluate different alternatives to encode information in the video stream in order to increase available throughput while preserving the packet-level characteristics of the video stream. We have built a censorship-resistant system, named DeltaShaper, which offers a data-link interface and supports TCP/IP applications that tolerate low throughput / high latency links. Our results show that it is possible to run standard protocols such as FTP, SMTP, or HTTP over Skype video streams.
Private Set Intersection for Unequal Set Sizes with Mobile Applications
Authors: Kiss Ágnes , Liu Jian , Schneider Thomas , Asokan N. , Pinkas Benny 
Published: October 2017

Abstract
Private set intersection (PSI) is a cryptographic technique that is applicable to many privacy-sensitive scenarios. For decades, researchers have been focusing on improving its efficiency in both communication and computation. However, most of the existing solutions are inefficient for an unequal number of inputs, which is common in conventional client-server settings. In this paper, we analyze and optimize the efficiency of existing PSI protocols to support precomputation so that they can efficiently deal with such input sets. We transform four existing PSI protocols into the precomputation form such that in the setup phase the communication is linear only in the size of the larger input set, while in the online phase the communication is linear in the size of the smaller input set. We implement all four protocols and run experiments between two PCs and between a PC and a smartphone and give a systematic comparison of their performance. Our experiments show that a protocol based on securely evaluating a garbled AES circuit achieves the fastest setup time by several orders of magnitudes, and the fastest online time in the PC setting where AES-NI acceleration is available. In the mobile setting, the fastest online time is achieved by a protocol based on the Diffie-Hellman assumption.