bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left Anterior Descending Coronary Artery and Multiple Peripheral Mycotic Aneurysms Due to Mycobacterium Bovis Following Intravesical Bacillus Calmette-Guerin Therapy: A Case Report
Authors: Duvnjak Petar , Laguna Mario 
Published: August 2016

The use of live attenuated intravesicular Bacillus Calmette-Guerin (BCG) therapy is a generally accepted safe and effective method for the treatment of superficial transitional cell carcinoma (TCC) of the bladder. Although rare, < 5% of patient's treated with intravesicular BCG therapy may develop potentially serious complications, including localized infections to the genitourinary tract, mycotic aneurysms and osteomyelitis. We present here a case of a 63-year-old male who developed left coronary and multiple peripheral M. Bovis mycotic aneurysms as a late complication of intravesicular BCG therapy for superficial bladder cancer. The patient initially presented with acute onset pain and swelling in the left knee > 2 years following initial therapy, and initial workup revealed a ruptured saccular aneurysm of the left popliteal artery as well as incidental bilateral common femoral artery aneurysms. Following endovascular treatment and additional workup, the patient was discovered to have additional aneurysms in the right popliteal artery and left anterior descending artery (LAD). Surgical pathology and bacterial cultures obtained from the excised femoral aneurysms and surgical groin wounds were positive for Mycobacterium Bovis, and the patient was initiated on a nine-month antimycobacterial course of isoniazid, rifampin and ethambutol. Including the present case, there has been a total of 32 reported cases of mycotic aneurysms as a complication from intravesicular BCG therapy, which we will review here. The majority of reported cases involve the abdominal aorta; however, this represents the first known reported case of a coronary aneurysm.
The DNA Damage Response Regulates RAG1/2 Expression in Pre–B Cells through ATM-FOXO1 Signaling
Authors: Ochodnicka-Mackovicova Katarina , Bahjat Mahnoush , Maas Chiel , van der Veen Amélie , Bloedjes Timon A. , de Bruin Alexander M. , van Andel Harmen , Schrader Carol E. , Hendriks Rudi W. , Verhoeyen Els , Bende Richard J. , van Noesel Carel J. M. , Guikema Jeroen E. J. 
Published: August 2016

Abstract
The recombination activating gene (RAG) 1 and RAG2 protein complex introduces DNA breaks at Tcr and Ig gene segments that are required for V(D)J recombination in developing lymphocytes. Proper regulation of RAG1/2 expression safeguards the ordered assembly of Ag receptors and the development of lymphocytes, while minimizing the risk for collateral damage. The ataxia telangiectasia mutated (ATM) kinase is involved in the repair of RAG1/2-mediated DNA breaks and prevents their propagation. The simultaneous occurrence of RAG1/2-dependent and -independent DNA breaks in developing lymphocytes exposed to genotoxic stress increases the risk for aberrant recombinations. In this study, we assessed the effect of genotoxic stress on RAG1/2 expression in pre–B cells and show that activation of the DNA damage response resulted in the rapid ATM-dependent downregulation of RAG1/2 mRNA and protein expression. We show that DNA damage led to the loss of FOXO1 binding to the enhancer region of the RAG1/2 locus (Erag) and provoked FOXO1 cleavage. We also show that DNA damage caused by RAG1/2 activity in pre–B cells was able to downmodulate RAG1/2 expression and activity, confirming the existence of a negative feedback regulatory mechanism. Our data suggest that pre–B cells are endowed with a protective mechanism that reduces the risk for aberrant recombinations and chromosomal translocations when exposed to DNA damage, involving the ATM-dependent regulation of FOXO1 binding to the Erag enhancer region.
Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis
Authors: Hang Long , Blum Arthur M. , Kumar Sangeeta , Urban Joseph F. , Mitreva Makedonka , Geary Timothy G. , Jardim Armando , Stevenson Mary M. , Lowell Clifford A. , Weinstock Joel V. 
Published: August 2016

Abstract
Helminthic infections modulate host immunity and may protect people in less-developed countries from developing immunological diseases. In a murine colitis model, the helminth Heligmosomoides polygyrus bakeri prevents colitis via induction of regulatory dendritic cells (DCs). The mechanism driving the development of these regulatory DCs is unexplored. There is decreased expression of the intracellular signaling pathway spleen tyrosine kinase (Syk) in intestinal DCs from H. polygyrus bakeri–infected mice. To explore the importance of this observation, it was shown that intestinal DCs from DC-specific Syk−/− mice were powerful inhibitors of murine colitis, suggesting that loss of Syk was sufficient to convert these cells into their regulatory phenotype. DCs sense gut flora and damaged epithelium via expression of C-type lectin receptors, many of which signal through the Syk signaling pathway. It was observed that gut DCs express mRNA encoding for C-type lectin (CLEC) 7A, CLEC9A, CLEC12A, and CLEC4N. H. polygyrus bakeri infection downmodulated CLEC mRNA expression in these cells. Focusing on CLEC7A, which encodes for the dectin-1 receptor, flow analysis showed that H. polygyrus bakeri decreases dectin-1 expression on the intestinal DC subsets that drive Th1/Th17 development. DCs become unresponsive to the dectin-1 agonist curdlan and fail to phosphorylate Syk after agonist stimulation. Soluble worm products can block CLEC7A and Syk mRNA expression in gut DCs from uninfected mice after a brief in vitro exposure. Thus, downmodulation of Syk expression and phosphorylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs that limit colitis.
Is the adjective distinct from the noun as a grammatical category in biblical Hebrew?
Authors: Miller-Naudé Cynthia L. , Naudé Jacobus A. 
Published: August 2016

The adjective is a beleaguered category in biblical Hebrew grammar with many grammars of biblical Hebrew denying that the adjective is a category distinct from substantives. Within a variety of linguistic theories, the status of the adjective as a grammatical category is also debated. Cross-linguistically adjectives exhibit extraordinary variety: in some languages showing similarities to nouns, in others to verbs and in still others to both nouns and verbs. The debate concerning the status of the adjective is mirrored by the broader debate within contemporary linguistics concerning how the issue of grammatical categorisation ought to be approached. In this article, we re-examine the question of whether or not the adjective is a distinct grammatical category from the noun in biblical Hebrew. We approach the question of the status of the adjective as a grammatical category from two perspectives: morphology and syntax.
Differences and influencing factors related to underground water carbon
uptake by karsts in the Houzhai Basin, southwestern China
Authors: Zhang Junyi , Bian Zihao , Dai Minghong , Wang Lachun , Zeng Chunfen , Su Weici 
Published: August 2016

Abstract. Carbon sink in karstic areas is very important at a global scale. Consequently, accurate determination of the carbon sink of karst ecosystems has become a core issue in research. We used flow and carbon ion concentration data from three stations with different environmental background conditions in the Houzhai Basin, southwestern China, to analyse the differences in carbon uptake between stations and to determine their impact factors. The results show that carbon sink discharge was mainly controlled by the flow at each site. Preliminary analysis indicated that the rapid increase in flow only had a partial dilution effect on the ion concentrations due to the high speed and stability of chemical carbonate weathering. The Land-Use and Cover-Change (LUCC) type had important effects on the bicarbonate ion concentrations; under stable run-off conditions, the influence of flow variation on the ion concentration was lower than the effects of chemical carbonate weathering on bicarbonate ion concentrations under different environmental conditions (a comparison of Laoheitan and Liugu stations showed a difference of 150 %). However, if run-off increased significantly, the impact of run-off variation on bicarbonate ions was greater than the effects of chemical carbonate weathering caused under different environmental conditions. This work provides a reference for the calculation of the karst geological carbon sink.
Demolition and Defiance: The Stone Ground Church Dispute (2012) in East China
Authors: Chow Christie Chui-Shan 
Published: August 2016

ABSTRACTMuch has been written on the high-profile cases of church and cross demolitions in China’s metropolitan cities such as Wenzhou, Ningbo, and Hangzhou, but little attention is paid to the church demolition disputes in rural hinterlands. This article draws on my fieldwork among rural Seventh-day Adventists to examine a case of church demolition, known as the Stone Ground Church incident, in rural Zhejiang Province on May 4, 2012. This incident seems to have set a precedent for a regional anti-Christian campaign in 2013–14, because it signified a qualitative shift in the Chinese state’s anti-Christian discourse, from intra-/intergroup disputes over community resources toward officials’ condemnation of the churches for violating building and zoning codes. Beginning with an analysis of the outbreak of this rural church dispute, this study explores a variety of innovative strategies that Chinese Seventh-day Adventists deployed to defend their religious autonomy in the competitive sphere of village politics.
Slachtoffer van arbeidsuitbuiting?
Authors: Tielbaard Niki , van Meeteren Masja , Commandeur Xenia 
Published: August 2016

Victim of labour exploitation? A qualitative study revealing ideal-typical pathways to self-identification as a victim of human trafficking
Although the Netherlands criminalised some forms of labour exploitation as human trafficking, many cases remain undetected. This is probably due to low self-identification among victims. Whereas research revealed factors obstructing self-identification among victims, it remains unclear how some victims do arrive at self-identification. Drawing on in-depth interviews and focus group discussions with victims and professionals, this qualitative study identifies two ideal-typical pathways to self-identification. In the first trajectory self-identification is gradually formed through information gathering and deteriorating working conditions. In the second trajectory self-identification is triggered by a sudden vital event.
Human Adipose-Derived Stem Cells Expanded Under Ambient Oxygen Concentration Accumulate Oxidative DNA Lesions and Experience Procarcinogenic DNA Replication Stress
Authors: Bétous Rémy , Renoud Marie-Laure , Hoede Claire , Gonzalez Ignacio , Jones Natalie , Longy Michel , Sensebé Luc , Cazaux Christophe , Hoffmann Jean-Sébastien 
Published: August 2016

Abstract
Adipose-derived stem cells (ADSCs) have led to growing interest in cell-based therapy because they can be easily harvested from an abundant tissue. ADSCs must be expanded in vitro before transplantation. This essential step causes concerns about the safety of adult stem cells in terms of potential transformation. Tumorigenesis is driven in its earliest step by DNA replication stress, which is characterized by the accumulation of stalled DNA replication forks and activation of the DNA damage response. Thus, to evaluate the safety of ADSCs during ex vivo expansion, we monitored DNA replication under atmospheric (21%) or physiologic (1%) oxygen concentration. Here, by combining immunofluorescence and DNA combing, we show that ADSCs cultured under 21% oxygen accumulate endogenous oxidative DNA lesions, which interfere with DNA replication by increasing fork stalling events, thereby leading to incomplete DNA replication and fork collapse. Moreover, we found by RNA sequencing (RNA-seq) that culture of ADSCs under atmospheric oxygen concentration leads to misexpression of cell cycle and DNA replication genes, which could contribute to DNA replication stress. Finally, analysis of acquired small nucleotide polymorphism shows that expansion of ADSCs under 21% oxygen induces a mutational bias toward deleterious transversions. Overall, our results suggest that expanding ADSCs at a low oxygen concentration could reduce the risk for DNA replication stress-associated transformation, as occurs in neoplastic tissues.
Le Digital Storytelling
Authors: Truchon Karoline 
Published: August 2016

Cette contribution explique comment, avec des résidents d’un complexe de logements sociaux de Montréal et d’autres partenaires, nous avons tenté d’ajouter d’autres représentations de leurs réalités quotidiennes aux imageries, conceptions et stéréotypes véhiculés à leur propos dans des espaces médiatiques généralement occupés par des personnes expertes qui parlent sur et pour eux. Plus précisément, je détaille le premier de quatre volets d’une « infrastructure de visibilisation » codéveloppée ensemble entre 2008 et 2010 pendant ma recherche doctorale, volet qui s’est appuyé sur ledigital storytelling. Pour ce faire, je définis d’abord la visibilisation comme concept opératoire distinct de la visibilité qui peut potentiellement générer de la reconnaissance. Ensuite, je présente l’avènement et les particularités dudigital storytellingde même que sa pertinence ethnographique. Finalement, j’illustre les manières avec lesquelles nous avons « travaillé » la visibilisation au sein d’une infrastructure où ledigital storytellingest devenu autant un outil d’expression et de reconnaissance qu’une méthode et une posture de recherche.
La construction du corps, de l’être et du paraître à travers le « piratage corporel »
Authors: Duarte Bárbara Nascimento 
Published: August 2016

Cet article traite du thème de la modification corporelle d’un genre « extrême » en se focalisant sur la mouvance du body hacking, ou « piratage du corps ». Ancrée dans l’ère du tout technologique, elle s’illustre par l’émergence d’un modèle organique rationnel socialement de plus en plus étendu utilisant des matériaux artificiels développés par soi-même. On en trouve des exemples avec l’insertion de puces électroniques sous-cutanées, d’implants magnétiques, d’implants génitaux vibrants, ou encore avec le remplacement de l’épiderme par des plaques en titane. En augmentant la capacité sensorielle, ces « pirates du corps » proposent de nouvelles émotions qui participent au développement d’un rapport inédit à l’organisme. Parallèlement, ils ont pour objectif de déconstruire la normativité corporelle en s’émancipant de tout type de contrôle lié à la transformation corporelle. Nous proposons d’identifier le traitement que ces acteurs réservent au corps : quelle lecture en font-ils ? Et en conséquence, quel organisme construisent-ils et projettent-ils, et pour quel homme ? À travers un travail ethnographique international relatant l’ensemble de ces nouvelles pratiques liées aux modifications corporelles et à ses augmentations, cette étude identifie la mutation de l’organisme opérant au sein de nos sociétés. Elle met en évidence les nouvelles interactions que l’homme entretient avec la technique, non plus pour compenser un handicap, mais pour offrir des fonctions supplémentaires.
Du mouvement vers la science et de la science vers le mouvement : l’exemple du projet de « recherche féministe » de l’association Histoire du féminisme à Rennes
Authors: Porée Lydie 
Published: August 2016

Se revendiquant du féminisme, composée d’apprenties chercheuses en histoire, l’association Histoire du féminisme à Rennes travaille notamment à produire de la connaissance scientifique sur l’histoire des mobilisations féministes qui ont eu lieu dans cette ville de l’ouest de France. Les résultats de recherche sont ensuite diffusés auprès de différents publics. Ils sont à la fois des supports et des prétextes pour mener des actions féministes. Ce fonctionnement associatif, entre activisme féministe et production de savoirs, est caractéristique du féminisme de la deuxième vague. Les membres de l’association n’étant pas des chercheuses officiellement reconnues par l’institution universitaire française, quelles stratégies mettent-elles en place pour que leurs travaux, qui, de surcroît, portent sur un sujet de recherche peu valorisé, voire soulevant la méfiance et le sexisme, soient reçus comme valides scientifiquement? Le projet de l’association illustre les enjeux autour de la « recherche féministe ».
Les rapports sociaux de sexe et le lesbianisme dans le Québec contemporain
Authors: Lebreton Christelle 
Published: August 2016

Dans cet article, l’auteure met en dialogue des théories et des concepts phares du féminisme matérialiste qui ont servi de cadre à sa recherche doctorale intitulée « Rapports sociaux de sexe et sexualité dans le Québec contemporain : les trajectoires adolescentes lesbiennes ». Cette recherche permet d’illustrer le rôle structurant des rapports sociaux de sexe dans l’engagement des filles dans la romance hétérosexuelle.
L’auteure présente ainsi successivement la contribution de Delphy, celle de Guillaumin, de Rich, de Wittig et, enfin, de Mathieu, tout en positionnant leurs apports respectifs et en soulignant leur enrichissement ou approfondissement mutuel. Elle argumente également la nécessité d’articuler le concept de socialisation différentielle des sexes à la perspective de la contrainte à l’hétérosexualité pour rendre compte de l’expérience des jeunes lesbiennes, et plus largement des filles, à l’adolescence.
Anisotropy of ionic conduction in single-crystal LixLa(1−
x
)/3NbO3 solid electrolyte grown by directional solidification
Authors: Fujiwara Yasuyuki , Taishi Toshinori , Hoshikawa Keigo , Kohama Keiichi , Iba Hideki 
Published: August 2016

Abstract
The anisotropy of ionic conduction in a solid electrolyte (Li
x
La(1−

x

)/3NbO3) was experimentally confirmed for the first time. Ionic conduction measurements were carried out on the (100), (010), (001), (110), (111), and (112) planes of single-crystal ingots of Li
x
La(1−

x

)/3NbO3 grown by directional solidification. We found that the ionic conductivity in Li
x
La(1−

x

)/3NbO3 with x = 0.08 was 3.6 × 10−4 S cm−1 in the [100] and [010] directions, approximately 10 times higher than that in the [001] direction. Such anisotropy of the ionic conduction is discussed with respect to the characteristic layered structure of Li
x
La(1−

x

)/3NbO3.
Enhancing residual trapping of supercritical CO2 via cyclic injections
Authors: Herring Anna L. , Andersson Linnéa , Wildenschild Dorthe 
Published: August 2016

AbstractWe utilize synchrotron X‐ray tomographic imaging to investigate the pore‐scale characteristics and residual trapping of supercritical CO2 (scCO2) over the course of multiple drainage‐imbibition (D‐I) cycles in Bentheimer sandstone cores. Capillary pressure measurements are paired with X‐ray image‐derived saturation and connectivity metrics which describe the extent of drainage and subsequent residual (end of imbibition) scCO2 trapping. For the first D‐I cycle, residual scCO2 trapping is suppressed due to high imbibition capillary number (Ca ≈ 10−6); however, residual scCO2 trapping dramatically increases for subsequent D‐I cycles carried out at the same Ca value. This behavior is not predicted by conventional multiphase trapping theory. The magnitude of scCO2 trapping increase is hysteretic and depends on the relative extent of the sequential drainage processes. The hysteretic pore‐scale behavior of the scCO2‐brine‐sandstone system observed in this study suggests that cyclic multiphase flow could potentially be used to increase scCO2 trapping for sequestration applications.
The Atlantic Water boundary current in the Nansen Basin: Transport and mechanisms of lateral exchange
Authors: Våge Kjetil , Pickart Robert S. , Pavlov Vladimir , Lin Peigen , Torres Daniel J. , Ingvaldsen Randi , Sundfjord Arild , Proshutinsky Andrey 
Published: August 2016

AbstractData from a shipboard hydrographic survey near 30°E in the Nansen Basin of the Arctic Ocean are used to investigate the structure and transport of the Atlantic Water boundary current. Two high‐resolution synoptic crossings of the current indicate that it is roughly 30 km wide and weakly middepth‐intensified. Using a previously determined definition of Atlantic Water, the transport of this water mass is calculated to be 1.6 ± 0.3 Sv, which is similar to the transport of Atlantic Water in the inner branch of the West Spitsbergen Current. At the time of the survey a small anticyclonic eddy of Atlantic Water was situated just offshore of the boundary current. The data suggest that the feature was recently detached from the boundary current, and, due to compensating effects of temperature and salinity on the thermal wind shear, the maximum swirl speed was situated below the hydrographic property core. Two other similar features were detected within our study domain, suggesting that these eddies are common and represent an effective means of fluxing warm and salty water from the boundary current into the interior. An atmospheric low‐pressure system transiting south of our study area resulted in southeasterly winds prior to and during the field measurements. A comparison to hydrographic data from the Pacific Water boundary current in the Canada Basin under similar atmospheric forcing suggests that upwelling was taking place during the survey. This provides a second mechanism related to cross‐stream exchange of heat and salt in this region of the Nansen Basin.
Interplanetary and ionosphere scintillation produced by ICME 20 December 2015
Authors: Chashei I. V. , Tyul'bashev S. A. , Shishov V. I. , Subaev I. A. 
Published: August 2016

AbstractObservational data of scintillation monitoring with typical time about 1 s at the frequency 111 MHz are presented for the period between 18 and 23 December when interplanetary coronal mass ejection (ICME) of flare origin resulted in the geomagnetic storm on 20–21 December 2015 with Dst ≈ −200 nT. Our estimates show that the mean ICME speed between the solar corona and the start of interplanetary scintillation enhancement is close to the mean speed between the corona and the Earth. The strong increase of the nighttime scintillation level is observed after ICME coming to the Earth. Scintillation analysis of the individual radio sources shows that the 1 s night scintillation is of ionospheric origin and can be explained by an order increase of irregularity drift speed in the disturbed ionosphere.