bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methods for determining the molecular composition of knee joint structures in osteoarthritis: collagen, proteoglycans and water content: a systematic review
Authors: Raikov Bogdan , Lipina Marina , Azarkin Kirill , Goncharuk Yuliya , Vyazankin Ivan , Kalinsky Eugene , Kudrachev Tagir , Murdalov Emirkhan , Nagornov Eugene , Budylin Gleb , Shirshin Evgeny , Rovnyagina Nataliya , Cherepanov Vadim , Kurpyakov Anton , Telpukhov Vladimir , Belov Nikita , Pogosyan David , Kavalerskiy Gennadiy , Gritsyuk Andrey , Garkavi Andrey , Lychagin Alexey 
Published: September 2024

AbstractOsteoarthritis is a degenerative disease that affects articular cartilage, leading to changes on the macro and micro levels of this multi-component tissue. Understanding the processes underlying this pathology plays an important role in planning the following management tactics. Timely detection of the knee joint degradation at the level of tissue changes can prevent its progressive damage due to the early beginning of appropriate treatment. This study aimed to provide an overview of the current level of knowledge about the composition of cartilage and menisci using a wide range of different diagnostic methods. A systematic review of the literature published from 1978 to 2023 was conducted. Original studies of the knee joint cartilage (articular and meniscus) research, reporting content composition and mechanical properties, were included. Studies of the non-knee joint cartilage, tissue research other than cartilage and meniscus, or reporting treatment outcomes were excluded (n = 111). Thirty-one papers were included in this review, which reported on the composition of animal and human cartilage (articular and meniscus). The most frequently investigated parameters were quantitative proteoglycan determination and hydration level of the cartilage. Cartilage and meniscus degeneration, i.e., reduced collagen and proteoglycan content, reduced mechanical properties, and increased hydration level, was shown in every article about osteoarthritis. Among all diagnostic methods, laboratory methods (biochemical and histological analysis) are the most frequently used, compared to the instrumental ones (spectroscopy, MRI, and CT). At the same time, spectroscopy takes the lead and becomes the most common approach for determining cartilage composition (collagen and proteoglycans content).
Graphical Abstract
Major depression recurrence is associated with differences in obesity-related traits in women, but not in men
Authors: Bannert Urs , Siewert-Markus Ulrike , Klinger-König Johanna , Grabe Hans J. , Stracke Sylvia , Dörr Marcus , Völzke Henry , Markus Marcello R.P. , Töpfer Philipp , Ittermann Till 
Published: September 2024

Abstract

Background
Obesity-related cardiometabolic comorbidity is common in major depressive disorder (MDD). However, sex differences and MDD recurrence may modify the MDD-obesity-link.

Methods
Sex-specific associations of MDD recurrence (single [MDDS] or recurrent episodes [MDDR]) and obesity-related traits were analyzed in 4.100 adults (51.6% women) from a cross-sectional population-based cohort in Germany (SHIP-Trend-0). DSM-IV-based lifetime MDD diagnoses and MDD recurrence status were obtained through diagnostic interviews. Obesity-related outcomes included anthropometrics (weight, body mass index, waist- and hip-circumference, waist-to-hip ratio, waist-to-height ratio), bioelectrical impedance analysis of body fat mass and fat-free mass, and subcutaneous (SAT) and visceral adipose tissue (VAT) from abdominal magnetic resonance imaging. Sex-stratified linear regression models predicting obesity-related traits from MDD recurrence status were adjusted for age, education, and current depressive symptoms.

Results
790 participants (19.3%) fulfilled lifetime MDD criteria (23.8% women vs. 14.5% men, p<0.001). In women, MDDS was inversely associated with anthropometric indicators of general and central obesity, while MDDR was positively associated with all obesity-related traits, except waist-to-hip ratio and fat-free mass. In women, MDDR versus MDDS was associated with higher levels of obesity across all outcomes except fat-free mass. In men, MDD was positively associated with SAT regardless of MDD recurrence. Additionally, lifetime MDD was positively associated with VAT in men. Results remained significant in sensitivity analyses after exclusion of participants with current use of antidepressants.

Conclusions
The MDD-obesity association is modified by MDD recurrence and sex independent of current depressive symptoms. Accounting for sex and MDD recurrence may identify individuals with MDD at increased cardiometabolic risk.
Development of a Predictive Model for Emergency Department Utilization and Unanticipated Hospital Admission in Patients Receiving Cancer Treatment for Solid Tumor Malignancies
Authors: Watson Catherine H. , Alhanti Brooke , Zhao Congwen , Havrilesky Laura J. , Davidson Brittany A. 
Published: September 2024

PURPOSE Unanticipated health care resource utilization, in the form of either emergency department utilization (EDU) or hospital admission (HA), may be an indicator of lower-quality cancer care. The objective of this study was to develop a predictive model for EDU and HAs within 14 days of receipt of systemic therapy for patients with solid tumors. METHODS We abstracted electronic health data on oncology encounters from all patients receiving systemic therapy for solid tumors from March 1, 2015, to August 21, 2020, in the Duke University Health System. We defined a primary composite outcome of an EDU or HA within 14 days after the encounter and then developed a predictive model for the primary outcome using least absolute shrinkage and selection operator regression. To evaluate the model, we calculated the area under the receiver operator curve and the calibration slope. RESULTS Twelve thousand eight hundred ninety unique patients with 134,641 oncology encounters were included. Five thousand one hundred fifty of these patients (40.0%) had at least one EDU or HA within 14 days of at least one treatment. Forty-six variables were incorporated into the final model. The top predictors, in order of absolute value of the predictive coefficients, were temperature, systolic blood pressure, cancer group, and marital status. The model's AUC was 0.73 (95% CI, 0.722 to 0.732), indicating good sensitivity and specificity to outcome. CONCLUSION The model developed in this study demonstrated good sensitivity in identifying patients with solid tumors who are at highest risk for EDU or HA and could be implemented in clinical practice to allow for preventive outpatient interventions.
Protocol-Stipulated Dose Modification to Manage Chemotherapy-Induced Peripheral Neuropathy in Children, Adolescents, and Young Adults With High-Risk Hodgkin Lymphoma
Authors: Heneghan Mallorie B. , Parsons Susan K. , Keller Frank G. , Renfro Lindsay A. , Pei Qinglin , Rodday Angie Mae , Wu Yue , Punnett Angela , Belsky Jennifer A. , Henderson Tara O. , Kelly Kara M. , Castellino Sharon M. 
Published: September 2024

PURPOSE Brentuximab vedotin (BV) incorporation into frontline chemotherapy regimens improved outcomes for classic Hodgkin lymphoma (cHL). The shared mechanism of action of BV and vinca alkaloids as microtubulin inhibitors increased the potential risk of chemotherapy-induced peripheral neuropathy (CIPN). Rates of CIPN and use of protocol-stipulated dose modifications of a microtubulin inhibitor were examined on the Children’s Oncology Group AHOD1331 study, which compared BV, doxorubicin, vincristine (VCR), etoposide, prednisone, cyclophosphamide (BV-AVE-PC; BV arm) with bleomycin containing doxorubicin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide (ABVE-PC; standard arm) in patients with high-risk cHL ages 2-21 years. METHODS AHOD1331 required clinician grading and reporting of ≥grade 2 CIPN. Protocol-stipulated dose modifications of VCR preceded modification of BV for ≥grade 2 CIPN in the BV arm, but only required modification of VCR for ≥grade 3 in the standard arm. Outcomes included CIPN rates, dose modification of microtubulin inhibitors by study arm, clinical factors associated with dose modifications, and event-free survival (EFS) by the presence of dose modification. RESULTS Among the 582 patients who began protocol therapy, 112 developed ≥grade 2 CIPN. Cumulative incidence of CIPN did not differ by study arm (19.2 v 19.8%, P = .91). CIPN dose modifications occurred more frequently in the BV arm (9.5% v 2.8%, P = .001); however, most patients with CIPN on the BV arm received full-dose BV. EFS did not differ by the presence of dose modifications after accounting for study arm, age, sex, and stage, although older age was significantly associated with the risk of VCR dose modifications for CIPN. CONCLUSION A staged dose modification plan for vinca alkaloids and BV as administered in AHOD1331 minimized the effect of incorporating a second microtubulin inhibitor on CIPN without compromising treatment efficacy in the BV arm.
Morphogens in the evolution of size, shape and patterning
Authors: Mosby Lewis S. , Bowen Amy E. , Hadjivasiliou Zena 
Published: September 2024

ABSTRACT
Much of the striking diversity of life on Earth has arisen from variations in the way that the same molecules and networks operate during development to shape and pattern tissues and organs into different morphologies. However, we still understand very little about the potential for diversification exhibited by different, highly conserved mechanisms during evolution, or, conversely, the constraints that they place on evolution. With the aim of steering the field in new directions, we focus on morphogen-mediated patterning and growth as a case study to demonstrate how conserved developmental mechanisms can adapt during evolution to drive morphological diversification and optimise functionality, and to illustrate how evolution algorithms and computational tools can be used alongside experiments to provide insights into how these conserved mechanisms can evolve. We first introduce key conserved properties of morphogen-driven patterning mechanisms, before summarising comparative studies that exemplify how changes in the spatiotemporal expression and signalling levels of morphogens impact the diversification of organ size, shape and patterning in nature. Finally, we detail how theoretical frameworks can be used in conjunction with experiments to probe the role of morphogen-driven patterning mechanisms in evolution. We conclude that morphogen-mediated patterning is an excellent model system and offers a generally applicable framework to investigate the evolution of developmental mechanisms.
Evolving circuitries in plant signaling cascades
Authors: Zegers Jaccoline M. S. , Irisarri Iker , de Vries Sophie , de Vries Jan 
Published: September 2024

ABSTRACT
Land plants are astounding processors of information; due to their sessile nature, they adjust the molecular programs that define their development and physiology in accordance with the environment in which they dwell. Transduction of the external input to the respective internal programs hinges to a large degree on molecular signaling cascades, many of which have deep evolutionary origins in the ancestors of land plants and its closest relatives, streptophyte algae. In this Review, we discuss the evolutionary history of the defining factors of streptophyte signaling cascades, circuitries that not only operate in extant land plants and streptophyte algae, but that also likely operated in their extinct algal ancestors hundreds of millions of years ago. We hope this Review offers a starting point for future studies on the evolutionary mechanisms contributing to the current diversity and complexity of plant signaling pathways, with an emphasis on recognizing potential biases.
Association of the modified creatinine index with quality of life in haemodialysis patients
Authors: Zeng Jie , Wang Yijing , Li Hong , Wen Hongying 
Published: September 2024

Aims/Background The evaluation of health-related quality of life in patients undergoing maintenance haemodialysis has garnered increasing attention. The modified creatinine index, a surrogate marker for muscle mass, has been linked to various clinical outcomes. However, the relationship between modified creatinine index and health-related quality of life in maintenance haemodialysis patients remains unclear. This study aims to elucidate the association between modified creatinine index and health-related quality of life in individuals receiving maintenance haemodialysis. Methods This cross-sectional study included 217 maintenance haemodialysis patients. Health-related quality of life was assessed using the Kidney Disease Quality of Life Instrument. Collected data included general patient information, laboratory results, and haemodialysis-related parameters. The modified creatinine index was calculated based on gender, age, single-pool Kt/V (spKt/V), and pre-dialysis serum creatinine levels. Multiple linear regression models and smooth curve fitting were used to investigate the relationship between modified creatinine index and health-related quality of life. Subgroup analyses and interaction tests were performed to identify potential effect modifiers. Results The 217 maintenance haemodialysis patients had a mean age of 53.66±13.15 years and a median dialysis vintage of 39 (25–84) months; 120 (55.30%) were male. The mean health-related quality of life score was 55.76±10.33, and the mean modified creatinine index was 22.72±2.95 mg/kg/day. After adjusting for confounding factors, an increase in modified creatinine index was associated with an improvement in health-related quality of life (β=0.55, 95% CI: 0.04, 1.06, p = 0.033). No nonlinear relationship was identified between modified creatinine index and health-related quality of life by smooth curve fitting. Subgroup and interaction analyses indicated that the relationship between modified creatinine index and health-related quality of life was stable and not significantly influenced by age, gender, dialysis vintage, diabetes status, or body mass index (p > 0.05). Conclusion Modified creatinine index is positively correlated with health-related quality of life in maintenance haemodialysis patients, suggesting its potential utility in evaluating patient quality of life. Modified creatinine index could be clinically useful to improve the predictability of health-related quality of life in maintenance haemodialysis patients.
Nurses' attitude toward futile treatment and its relationship with missed care at the end of life
Authors: Hanifi Nasrin , Gholami Zahra , Moqaddam Masoumeh 
Published: September 2024

Background: Avoiding futile treatment for patients at the end of life is among one of the care challenges of nurses in intensive care units (ICUs). Aims: This study aimed to determine the attitude of intensive care unit nurses toward futile treatment and its relationship with missed care for patients at the end of life. Method: This cross-sectional study was conducted on 307 ICU nurses. Eleven teaching hospitals were selected from three Iranian provinces, Zanjan Province, East Azerbaijan and West Azerbaijan, in 2021. The data were collected using The Attitudes Toward Futile Treatment Scale (ATFTS) and The Missed Nursing Care Survey (MISSCARE Survey) as self-reports. Results: According to the obtained results, 94.8% of the nurses agreed that futile treatment should not be performed. However, 97.7% of the nurses reported that missed care occurs less for patients at the end of life. The correlation between the MISSCARE Survey's total scale and the ATFTS's total scale was positive and statistically significant (r =.11). Conclusion: This research contributes to understanding nurses' attitudes toward futile treatment. Nurses oppose futile treatment, so obstacles to avoiding it should be eliminated. This attitude does not have a significant impact on nursing care quality or missed care for patients at the end of life, but it can lead to enduring distress for nurses. It is recommended to study the reasons for futile treatment, and its link to nurses' mental and physical health.
Modeling Mechanical Properties of 2 by 4 and 2 by 6 Southern Pine Lumber Using Longitudinal Vibration and Visual Characteristics
Authors: França F. J. N. , Seale R. D. , Shmulsky R. , França T. S. F. A. 
Published: September 2024

Abstract
The light-frame building construction market is increasingly competitive. To maintain and grow its position in the market, the lumber industry needs to be improved and refined. The identification of the strength-reducing characteristics that affect modulus of elasticity (MOE) and modulus of rupture (MOR) are keys to improve the grading process of lumber. Herein, nondestructive techniques, visual evaluation, and mechanical testing were used to assess the structural properties of 1,044 samples of southern pine lumber. Linear regression models were constructed for 2 by 4 and 2 by 6 southern pine lumber using the static bending MOE and MOR, both as dependent variables from the destructive test. Nondestructive measurements, visual characteristics, and lumber density were used as independent variables. Linear regression models were constructed to indirectly estimate the MOE and MOR of southern pine lumber. The variables selected to predict MOE were dynamic modulus of elasticity (dMOE) and density. By adding knot diameter ratio to dMOE and density, it was possible to develop a prediction model for MOR. It was possible to improve predictability of strength (MOR) with a combination of nondestructive testing and knot evaluation.
Cellulose Nanofiber as Complete Natural Binder for Particleboard
Authors: Kojima Yoichi , Kato Naho , Ota Kazuaki , Kobori Hikaru , Suzuki Shigehiko , Aoki Kenji , Ito Hirokazu 
Published: September 2024

Abstract
The demand for wood-based materials as an alternative to plywood is increasing, and a synthetic adhesive is typically used for the fabrication of such materials. The identification of replacements for standard adhesives poses a major challenge. In this study, we investigated the mechanical properties of particleboard bonded by cellulose nanofiber (CNF) and compared the mechanical properties of particleboard bonded by CNF with those of particleboard bonded by adhesive. CNF was added together with wood particles during the fabrication process. The target CNF addition amounts were 0, 3, 5, 10, and 20 weight percent. The bending and internal bond strengths of the particleboard with CNF increased, and its water absorption decreased as CNF content increased. The comparison between the boards prepared with adhesives and those with CNF showed that the properties of boards prepared with 20 weight percent CNF were comparable to those of boards prepared with 1 weight percent synthetic adhesive.
Analysis of interference fringes in a long-wave infrared full Stokes polarimeter based on rotating waveplates
Authors: Gao Biyuan , Hou Junfeng , Shen Yuliang , Sun Yingzi , Wang Dongguang , Yang Xiao , Deng Yuanyong 
Published: September 2024

In the long-wave infrared (LWIR, 8–15 µm) band, the interference effect of polarization elements becomes an issue in polarimetry due to defects in the anti-reflective coatings. The paper describes an analysis and optimization method for the rotating-waveplates-based Stokes polarimeter, to eliminate interference fringes and improve polarization measurement accuracy in LWIR. An interference model was established based on the theory of polarized light and thin-film optics. Different modulation schemes were simulated and analyzed to obtain an optimized Stokes polarimeter, reducing the instrumental polarization to less than 1E-3. Furthermore, experimental validation was conducted by the Accurate Infrared Magnetic Field Measurements of the Sun (AIMS) telescope. The result shows that the instrumental polarization was less than 2E-3, consistent with the simulation.
Comparative study of spectroscopic properties of Er3+-ion doped K2O/KF-Gd2O3-P2O5 glass systems
Authors: Khan I. , Shoaib M. , Chanthima N. , Intachai N. , Ali Mohamed , Kothan S. , Ullah I. , Mukamil Seema , Rooh G. , Kaewkhao J. 
Published: September 2024

The two phosphate glasses with composition 17K2O−17Gd2O3−65P2O5−01Er2O3 and 17KF−17Gd2O3−65P2O5−01Er2O3 composition were synthesized by conventional-melt quenching techniques to study comparatively the spectroscopic, Judd–Ofelt (JO), radiative properties and NIR-luminescent properties. The Urbach energy of K2O−Er and KF-Er samples was 0.3547 and 0.4799 eV. The observed trend is Ω2>Ω4>Ω6 and Ω2>Ω6>Ω4 for JO-intensity-parameters for K2O−Er and KF-Er glasses. Moreover, K2O−Er has higher Ω4 and Ω6 values, thus having more rigidity and viscosity than KF-Er. The measured values of full-width-half-maximum (FWHM) for K2O−Er and KF-Er glasses 54.60 and 58.27, respectively. The measured values of FWHM for K2O−Er and KF-Er glasses were 54.60 and 58.27, respectively. The A
R
values are 417.61 and 3038 for K2O−Er and KF-Er glasses, respectively. The radiative lifetime (τ
R
) for K2O−Er and KF-Er glasses is 2.39 ms and 3.18 ms, respectively. Utilizing McCumber theory the G(λ,β) is positive and population-inversion is more than 0.4 for both glasses. Both samples have flat gain-bandwidth in the range of 1505–1585 nm, which covers the S-, C-, and L-bands of the low-loss optical communication-window. It is evident from all these results that the prepared glass samples have the potential for a low-threshold and high gain NIR laser and optical-fiber amplifier.