bluuebunny/crossref_metadata_2025_split huggingface dataset:
P089 RELATION BETWEEN ISOMETRIC STRESS-INDUCED PRESSURE RESPONSE AND P-WAVE OF THE ELECTROCARDIOGRAM
Authors: Rufino Nuñez Harline Raquel , Carmona Puerta Raimundo , Lorenzo Martinez Elizabeth , Gonzalez Katia Hurtado , Batista Yajaira A. Flete , Sanchez Marielys Del Carmen Martinez , Gomez Calderon Jose Bernardo , Peñaló Batista Joel 
Published: September 2024

Background and objectives:
The effects of isometric stress-induced vascular hyperreactivity on P wave duration have scarcely been studied. We set out to determine the relationship between isometric stress reactivity and the P wave in young hypertensives.

Materials:
A cross-sectional, prospective study was carried out on the relationship between the duration of the maximum P wave corrected for heart rate (Pmaxc) and the degree of blood pressure reactivity in two groups of 30 young men, who were divided into normotensive and hypertensive patients. The hypertensive patients were of recent clinical diagnosis. Vascular reactivity was measured by the sustained weight test (PPS).

Results:
Diastolic blood pressure variation (ΔPAD) was greater in hypertensives than in normotensives (15.83 mmHg ± 7.321 vs. 10.17 mmHg ± 5.331, p<0.01) after application of the PPS. The ΔPAD correlated positively with Pmaxc in both groups studied, but was only significant in the hypertensive group (r=0.433; p<0.05).

Conclusions:
Increasing levels of isometric stress induced by PPS correlate positively and significantly with Pmaxc.

Figure 1: Correlation between diastolic blood pressure reactivity (ΔPAD) and heart rate correction for peak P wave (Pmaxc) in hypertensives and normotensives
P095 LEFT VENTRICULAR DIASTOLIC FUNCTION IN HYPERTENSIVE PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Zhemanyuk Svitlana , Syvolap Vitaliy 
Published: September 2024

The aim of this work was to study the prevalence of the left ventricular diastolic dysfunction and indeterminate diastolic function in sinus hypertension individuals with left ventricular hypertrophy and preserved ejection fraction, and its associated factors.

Methods.
We enrolled 56 patients (aged 62, 95% confidence intervals (CI) 58–65 years, 53.6% men) with uncontrolled in-treated arterial hypertension who underwent transthoracic echocardiography (TTE, Esaote, MyLabEight). Cardiac diastolic dysfunction was defined when more than half of the TTE criteria was met according to the existing algorithm (average E/e‘, septal / lateral e‘, tricuspid regurgitation velocity, left atrium volume) and indeterminate one, when half of the criteria was encountered.
A binary logistic regression analysis (Stata 15, USA) was performed to evaluate parameters for indeterminate diastolic function state.

Results.
TTE detected the left ventricular diastolic dysfunction only in 5.4%, however, 80.0% subjects had indeterminate diastolic function. Associated with the indeterminate diastolic function pattern factors were age and mitral regurgitation (odds ratios (OR) 8.0, 95% CI 2.19-29.25, p=0.002 and OR 1.06, 95% CI 1.01-1.12, p=0.014, respectively), however, not sex, height, weight, body mass index, diabetes, overweight/obese, and E/e‘. After adjustment for age, sex (female vs male) mitral regurgitation was occurred significantly more often in patients with indeterminate diastolic function in multivariate logistic regression model (OR 5.97, 95% CI1.47-24.35, p=0.013).

Conclusions.
Prevalence of the left ventricular diastolic dysfunction pattern is low (5.4%) and the indeterminate diastolic function is considerable (80.0%) in cohort of hypertensions with preserved ejection fraction with sinus rhythm. Mitral regurgitation identifies as a factor that associated with the indeterminate diastolic function patterns in hypertension patients.
P096 LEFT VENTRICULAR HYPERTROPHY PATTERNS IN HYPERTENSIVE SUBJECTS WITH CHRONIC KIDNEY DISEASE
Authors: Zhemanyuk Svitlana , Syvolap Vitaliy , Lukashenko Lanna 
Published: September 2024

Background and Objective.
A left ventricular (LV) geometric pattern classification based on its concentrically and dilatation has been recommended for clinical practice use. However, there is no clear data demonstrating whether such categorization could improve the diagnostic strategy of adult hypertensives with chronic kidney disease (CKD).
The aim of the study was to analyze LV hypertensive patterns in adult individuals with arterial hypertension and CKD.

Methods.
We studied 56 hypertension in-treated individuals with sinus rhythm (mean age, 62 [95% CI, 58–65] years, 46.4% women) using transthoracic echocardiogram (Esaote, MyLabEight). There were no pregnant women and objects engaged in professional sport. LV geometric patterns classified according to LV mass, volume, and relative wall thickness were analyzed. Moreover, CKD stages were studied with glomerular filtration rate calculation (the CKD-EPI creatinine equation).

Results.
Concentric hypertrophy (24/56) for 1-4 CKD stages, mixed hypertrophy (1/56) for the 4th CKD stage, dilated hypertrophy (12/56) for 2-3 CKD stages, normal/physiological hypertrophy (14/56) for 1-3 CKD stages, and the eccentric hypertrophy (4/56) for 1-3 CKD stages were detected. Objects with the stage 1 CKD had mainly normal/physiological hypertrophy (44.4%), with stages 2 and 3 CKD had concentric hypertrophy (43% and 48%, respectively), and with the 4 CKD had the same rate of concentric and mixed hypertrophy (50%).

Conclusions.
It was found different LV hypertensive geometric patterns among hypertensive individuals with CKD. Unexpectedly, there was a large amount of the normal/physiological hypertrophy pattern in arterial hypertension individuals with CKD, mainly with the stage 3.
P100 ALPHA KETOGLUTARATE RECEPTOR 1 REGULATES THE EXPRESSION OF THE (PRO)RENIN RECEPTOR IN MEDULLARY RENAL TISSUES, MODULATES SODIUM EXCRETION AND ATTENUATES TWO-KIDNEY, ONE-CLIP GOLDBLATT HYPERTENSION IN MICE
Authors: Gonzalez Alexis A. , Nuñez-Allimant Camila , Silva Katherin , Prieto Minolfa C. , Vallotton Ms. Zoe , Lorca Ramón A. , Casarini Dulce E. , Cespedes Carlos , Cardenas Ms. Pilar 
Published: September 2024

Background:
The two-kidney, one-clip (2K1C) Goldblatt model elicits a reduction of renal blood flow (RBF) in the clipped kidney (CK). The reduced RBF and oxygen bio ability causes the accumulation of the intermediary of the tricarboxylic cycle, α-ketoglutarate, which activates the oxoglutarate receptor-1 (OXGR1). In the kidney, the OXGR1 is abundantly expressed in intercalated cells (IC) of the collecting duct (CD), which may contribute to Na+ transport and electrolyte balance. The (pro)renin receptor (PRR), a member of the renin-angiotensin-aldosterone system is a key regulator of Na+ reabsorption, and blood pressure (BP) and is also expressed in IC. PRR is upregulated in 2K1C. Here, we tested the hypothesis that reduction of RBF in the CK leads to OXGR1-dependent PRR upregulation in the CD and alterations of Na+ balance and BP in 2K1C mice.

Methods:
To determine the role of OXGR1 in regulating PRR in the CDs during renovascular hypertension, we used 2K1C Goldblatt surgery (clip= 0.13 mm internal gap) in two groups of male mice: 1) Oxgr1-/- knockout (n=6) mice; and 2) mice treated with Montelukast (OXGR1 antagonist; 5 mg/Kg/day, n=6). WT and sham-operated mice were used as controls.

Results:
2K1C mice showed increased systolic BP (SBP) (108 ± 11 vs. control 82 ± 5 mmHg, p<0.01) and a lower natriuretic response after the saline challenge test. The CK showed augmented levels of α-ketoglutarate, erythropoietin mRNA levels, PRR (mRNA and protein abundances) in the renal medulla. Non-CK showed PRR upregulation in the CDs. However, the CK of Oxgr1-/- knockout mice, and from those subjected to OXGR1 antagonism, elicited impaired PRR upregulation, attenuated SBP (Oxgr1-/- 2K1C: 90 ± 8 mmHg, p=non-significant vs. control; Montelukast 2K1C: 95 ± 3 mmHg, p<0.05 vs. control) and better natriuretic responses.

Conclusion:
In 2K1C mice, the effect of reduced RBF on the OXGR1-dependent PRR upregulation in the CK may contribute to the anti-natriuretic and increased SBP responses.
P110 INITIAL TREATMENT WITH A SINGLE CAPSULE CONTAINING HALF-DOSE QUADRUPLE THERAPY VS STANDARD-DOSE DUAL THERAPY IN HYPERTENSIVE PATIENTS (QUADUAL): A RANDOMIZED, BLINDED, CROSSOVER TRIAL
Authors: Zhao Xiexiong , Liu Tao , Yang Qiong , Yang Guoping , Li Xingli , Tang Xiaohong , Li Lingle , Liang Zhongshu , Li Anying , Zeng Lixiong , Wen Juan , Peng Liping , Cai Jingjing , Li Xiaogang , Jiang Weihong 
Published: September 2024

Background and Objective:
Guidelines recognized the dual combination in initial antihypertensive therapy. Studies demonstrated low-dose quadruple combination antihypertensive was superior to monotherapy. However, whether low-dose quadruple therapy is better than dual combination is unknown.

Methods:
A randomized blinded crossover trial was conducted to compare the efficacy and safety of low-dose quadruple antihypertensives (irbesartan 75 mg + metoprolol 23·75 mg + amlodipine 2·5 mg + indapamide 1·25 mg) with standard-dose dual antihypertensives (irbesartan 150 mg + amlodipine 5 mg) in the initial treatment of patients with mild to moderate hypertension. Patients were randomly assigned in a 1:1 ratio to two crossover sequences. Each sequence received four-weeks of either half-dose quadruple antihypertensives or standard-dose dual antihypertensives, followed by a two-week washout and crossover for four-weeks. Participants and researchers were blinded, except for randomization and drug coding. The primary outcome was the reduction of mean 24-hour systolic blood pressure in ambulatory blood pressure monitoring. Safety outcomes were adverse events and changes in biochemistry after treatment. Analyses were per intention to treat. This trial was prospectively registered on www.clinicaltrials.gov (NCT05377203), and is now complete.

Results:
A total of 90 eligible participants were randomized between July 13, 2022, and April 20, 2023. The mean age of the population was 43.88 years, and 25.6% were women. The mean baseline 24-h blood pressure was 145.59/93.84 mm Hg. Half-dose quadruple treatment compared with standard-dose dual treatment further reduced mean 24-hour blood pressure by 4.72/4.17 mm Hg (P < 0.001 for both systolic and diastolic blood pressure). Except for fasting blood glucose (P = 0.029) and blood uric acid increased significantly (P < 0.001) in half-dose quadruple group, other adverse events and changes in laboratory values between the two treatments were not statistical different.

Conclusions:
Initiating treatment with half-dose quadruple combination therapy was more effective in lowering blood pressure than standard-dose dual therapy. The safety of half-dose quadruple therapy was comparable.
P115 CLINICAL PROFILE AND PREVALENCE OF OBSTRUCTIVE SLEEP APNEA IN A POPULATION OF YOUNG ADULTS REGISTERED IN A PRIMARY CARE UNIT IN RIO DE JANEIRO
Authors: Light Maria Beatriz , Guizzo Maria Eduarda Bazzanelli , Magalhães Victoria Enne , Lima Sara dos Santos , Neno João Oliveira Góes , Silva Camila Moura , da Silveira João Pedro Soares , Vargas Isabella Lima , Bassani Patrícia Barros , Ramirez Breno Garcia , Castellões Pedro Paulo , Westgarth Harrison James , Reiniack Suelen , Muxfeldt Elizabeth Silaid , Fernandes Ana Cristina Tenório 
Published: September 2024

Background:
Obstructive Sleep Apnea (OSA) is strongly associated with high blood pressure (BP) and cardiovascular risk (CVR). There is a lack of studies and specific screening for younger populations, which could allow for early intervention and potentially reduce CVR.

Objective:
Analyze the prevalence and clinical profile of OSA, identifying the best screening method in a young population attended by a Family Health Strategy Unit in Rio de Janeiro.

Methods:
Cross-sectional population study of adults between 20 and 65 years old. Sociodemographic characteristics, anthropometric measures and CVR were obtained. Office BP was calculated using two measurements. The risk of OSA was assessed using STOP-BANG (SB) and Epworth Sleepiness Scale (ESS) questionnaires. All underwent home polysomnography.

Result:
67 individuals included [38.9% men; average age of 38.9 ± 8 years]: 35 without OSA, 20 with mild OSA, 9 with moderate OSA and 3 with severe OSA. The prevalence of moderate/severe OSA was 18%. Individuals with moderate/severe OSA were older, more obese, had higher prevalence of increased neck circumference, dyslipidemia and heart rate. High risk for OSA in screening by SB, ESS and both questionnaires was respectively 55.2%, 44.8% and 19.4%. SB confirmed moderate/severe OSA in 30% in high-risk individuals, and excluded in 97% of low risk, with 60% accuracy. The sensitivity, specificity, PPV and NPV of SB to identify moderate/severe OSA were respectively 92%, 53%, 36% and 97%. In those with high risk according to the ESS, moderate/severe OSA was confirmed in 13%, while in those with low risk it was excluded in 78%. The accuracy of the ESS was 49%. The sensitivity, specificity, PPV and NPV of the ESS to identify moderate/severe OSA were respectively 33%, 53%, 13% and 78%.

Conclusion:
Moderate/severe OSA was more associated with an adverse metabolic profile than with high BP. The best screening questionnaire for this population is the STOP-BANG.
P117 PREVALENCE OF UNDIAGNOSED HYPERTENSION AND RELATED RISK FACTORS IN WAD-MEDANI ALKOBRA LOCALITY IN GEZIRA STATE, SUDAN, 2022
Authors: Elameen Sawsan , Elmubarak Mohab , Elmubarak Mohannad , Ahmed Farah , Alhamid Mustafa , Elamin Abubakr , Ibrahim Raghda , Abukoe Mawada 
Published: September 2024

Background:
Hypertension is defined as blood pressure ≥140/90 mm Hg. It is emerging as one of the major healthcare challenges in low- and middle-income countries. Hypertension is considered a silent killer and is the leading risk factor for cardiovascular mortality and accounts for a large proportion of premature deaths in developing countries. Most people with hypertension are asymptomatic and have been undiagnosed for years.

Objectives:
This study aimed to find out the prevalence of undiagnosed hypertension and related risk factors among adults in Wad Medani Alkobra locality in Gezira State, Sudan.

Methods:
A community-based cross-sectional study involving 464 adults in different locations in Wad-Medani Alkobra locality, from June 2022 to August 2022 was performed in collaboration with the Sudanese Society of Hypertension. WHO Stepwise Approach to Surveillance (STEPS) questionnaire was used to collect data, and was analyzed by SPSS version 20. Demographics, blood pressure, pulse, and socioeconomic status were measured. Diagnosis of hypertension was defined based on systolic and diastolic blood pressure of ≥140 mmHg and ≥90 mmHg, respectively, and three readings were obtained. Blood pressure was measured in all women and men aged 15 years and above.

Results:
The total number of study population was 464, males were 239, females were 225. The mean age was 45 years. 68 were known hypertensive. Of those who were hypertensive, 27 had high blood pressure. Undiagnosed hypertension in the study population was found to be 10% which equals 59.1% of the total number of the populations who had HTN. The prevalence of HTN in this study group was 25%. There was a positive relation between high blood pressure and old age, diabetes mellitus increased body weight, and sex (more common in males).

Conclusion:
The prevalence of hypertension was high and associated with some modifiable risk factors which should be addressed. Frequent screening and proper treatment are required to prevent complications of this epidemic.
P120 FRUITS AND VEGETABLES CONSUMPTION, PHYSICAL ACTIVITY AND ADHERENCE TO RISK FACTORS MODIFICATION AMONG ACADEMIC STAFF OF A STATE PEDAGOGICAL UNIVERSITY
Authors: Gasımov Zaur , Dadashova Gulnaz , Javadova Tarana , Abdullayeva Shahzoda , Allazova Shafa , Jafarov Rasim , Behbudova Jamila , Əliyeva Ilaha 
Published: September 2024

Objective:
The aim of our study was to examine level of management of the risk factors of cardiovascular diseaseas well as physical activity level in an academic staff of a State Pedagogical University. Hypertension, awareness, control of disease and obesity(overweight) rate, as well as other risk factors were in the focus of this study.

Design and method:
107(16,5%)subjects,80(74,8%) female,27(25,2%)male, age 24-81, represented sample of 648 subjects of the academic staff of Azerbaijan State Pedagogical University. Intended to participate subjects (consent forms were signed) were interviewed by assessment of modified STEPS questionnaire (WHO). Participants were underwent physical examination: measurement of weight and height, waist circumference, waist-to-hip ratio; calculation of mean of 3 sitting BP measurements(automatic BP measurement device A&D UA 888(Japan).Fasting blood glucose (glucometers Optium Xceed Abbot and FIA Biomed Salut) and total cholesterol in capillary blood (device 3 in1 Slovenia) were measured.

Results:
40(39%) out of 103 were obese, 41(40%) were overweight and only 22(21%) had normal body mass index. Majority of participants reported low consumption of fruit and vegetables, high consumption of salt, and salty beverages, low physical activity.
All of 80 women reported no smoking until the time of the interview. Few of them reported second smoking. 8 men reported smoking and 6 –no smoking, from those 4 men give up to smoke more than 5 years before the time of interview. Cholesterol and glucose level and smoking status were available in 55 out of 107 participants .44 (80.%) had a raised total cholesterol level (≥ 5 mmol/L or taking medication for hypercholesterolemia).12(11%) out of 107 had T2D, from those, possibly, 2 subjects had new onset. Impaired fasting glucose had 15, normal range of fasting glucose had 22participants.7 out of 55 had 3 risk factors,10 out of 55 had 2 risk factors

Conclusion:
Strategy to improve dietary status, adherence to low salt usage, hypertension awareness, treatment and control, measures to increase adherence to lifestyle modification must be a public health priority.
P123 ASSOCIATION OF VERY SHORT INTERNVAL HEART RATE MEAN ABSOLUTE DEVIATION WITH HYPERTENSION: FROM NHANES 2017- 2020
Authors: Kulthamrongsri Narathorn , Nuchpramool P , Kookanok C , Kanthajan T , Prasitsumrit V , Sripusanapan A , Wareesawetsuwan N , Sodsri T , Suriyathumrongkul N , Yinadsawaphan T , Wattanachayakul P , Thiravetyan B , Suenghataiporn T , Srikulmontri T , Tantisattamo E 
Published: September 2024

Background:
Heart Rate Variability (HRV) has recently gained popularity as an indicator of cardiovascular health. However, the association between the Mean Absolute Deviation of Heart Rate (HR-AMD), one of the HRV parameters, and Hypertension (HT), especially in very short intervals, in a nationally representative population, remains unknown. This study aims to investigate the relationship between HR-AMD and HT in the general population.

Methods:
A cross-sectional analysis of data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES) was conducted to explore the association. Participants had their heart rate measured three consecutive times, 60 seconds apart, using a digital device. HR-AMD was calculated and categorized into quartiles. HT data were collected through self-reporting. Logistic regression models, comparing participants with HR-MAD in Q1 to those in higher quartiles and adjusting for demographics and comorbidities, were analyzed.

Results:
The study included 9,204 adult participants with a mean HR-AMD of 0.02 beats per minute. Among them, 3,554(38.61%) experienced HT.
In the general population, hypertension is lower in Q2-Q4, with statistically significant differences noted in Q2 with Odd ratio (OR) 0.80.
After stratification by race and diabetic status (DM), there was a non-statistically significant negative association of 0.90 times with HT in Q2 of HR-AMD among White participants, while among Black participants, the OR were statistically significantly lower at 0.70 times.
There also was a non-statistically significant negative association of 0.91 times with HT in Q2 of HR-AMD among DM individuals, while among non-DM individuals, the OR were statistically significantly lower at 0.78 times.

Conclusions:
A very short interval HR-AMD shows a negative association with HT in the general population, especially statistically significant in Q2. The greater negative associations only in black and non DM populations suggest that DM status and race may act as effect modifiers in the Q2 of HR-AMD. Further studies are required for a deeper understanding of this relationship.
P128 ESTABLISHING A RELATIONSHIP BETWEEN BLOOD PRESSURE AND HANDGRIP STRENGTH AMONG OBESE PATIENTS
Authors: Patil Mansi , Patil Vishal 
Published: September 2024

Background:
While grip strength is known to correlate with cardiovascular health, its relationship with blood pressure (BP) remains unclear, especially when considering adiposity.

Methods:
We investigated the grip strength-BP association in 12,000 individuals aged 18–65 years, stratifying by body mass index (BMI) and Dietary diversity (DDS). Grip strength, BP, and Body-fat(BF%) were measured using hand dynamometry, digital blood pressure instrument, and dual-energy x-ray absorptiometry. DDS was measured using the FAO validated DDS tool.

Results:
Overall, elevated BP was associated with greater grip strength (37.1 kg vs 36.5 kg, p < 0.001), particularly in overweight or obese individuals (42.0 kg vs 40.2 kg, p = 0.003 and 41.7 kg vs 40.0 kg, p = 0.03), and those in the highest DDS (12 Vs 9, p < 0.01). Higher grip strength increased the odds of elevated BP (OR = 1.014, p = 0.004), particularly in overweight or obese individuals (OR = 1.025, p < 0.001) and those with the highest DDS (OR = 1.036, p < 0.001). However, individuals with low grip strength and high DDS had lower odds of elevated BP (OR = 0.514, p = 0.002), while those with low grip strength and low DDS had higher odds (OR = 2.162, p = 0.043).

Conclusion:
Our study reveals that increased grip strength is linked to higher blood pressure in overweight or obese individuals or those with a high dietary diversity score (DDS). However, individuals with a BMI < 25 kg/m2 or lower DDS may experience a reduced association between grip strength and blood pressure. These findings underscore the importance of considering both body mass index and dietary diversity in assessing cardiovascular health. We suggest integrating dietary analysis and handgrip evaluation in hypertension screening. Intervention trials combining dietary modifications with strength training are vital. Further research is warranted to explore the underlying mechanisms and potential interventions targeting grip strength, adiposity, and dietary factors to mitigate the risk of hypertension.