bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amyloid-β-induced Alteration of Fast and Localized Calcium Elevations in Cultured Astrocytes
Authors: Nakata Kaito , Sakamoto Joe , Otomo Kohei , Sato Masanao , Ishii Hirokazu , Tsutsumi Motosuke , Enoki Ryosuke , Nemoto Tomomi 
Published: September 2024

AbstractAlzheimer’s disease (AD) is a progressive neurodegenerative disorder that causes cognitive decline. Uncovering the mechanisms of neurodegeneration in the early stages is essential to establish a treatment for AD. Recent research has proposed the hypothesis that amyloid-β (Aβ) oligomers elicit an excessive glutamate release from astrocytes toward synapses through intracellular free Ca2+([Ca2+]i) elevations in astrocytes, finally resulting in neuronal dendritic spine loss. Under physiological conditions, astrocytic [Ca2+]ielevations range spatially from microdomains to network-wide propagation and temporally from milliseconds to tens of seconds. Astrocytic localized and fast [Ca2+]ielevations might correlate with glutamate release; however, the Aβ-induced alteration of localized, fast astrocytic [Ca2+]ielevations remains unexplored.In this study, we quantitatively investigated the Aβ dimers-induced changes in the spatial and temporal patterns of [Ca2+]iin a primary culture of astrocytes by two-photon excitation spinning-disk confocal microscopy. The frequency of fast [Ca2+]ielevations occurring locally in astrocytes (≤0.5 s, ≤35 µm2) and [Ca2+]ievent occupancy relative to cell area significantly increased after exposure to Aβ dimers.The effect of Aβ dimers appeared dose-dependently above 500 nM, and these Aβ dimers-induced [Ca2+]ielevations were primarily mediated by a metabotropic purinergic receptor (P2Y1 receptor) and Ca2+release from the endoplasmic reticulum. Our findings suggest that the Aβ dimers-induced alterations and hyperactivation of astrocytic [Ca2+]iis a candidate cellular mechanism in the early stages of AD.
Human untargeted metabolomics in the gut microbiome era: ethanol vs methanol
Authors: Zuffa Simone , Charron-Lamoureux Vincent , Brennan Caitriona , Ambre Madison , Knight Rob , Dorrestein Pieter C. 
Published: September 2024

AbstractUntargeted metabolomics is frequently performed on human fecal samples in conjunction with sequencing to unravel gut microbiome functionality. As sample collection efforts rapidly expand, with individuals often collecting specimens at home, metabolomics experiments should adapt to accommodate the safety and needs of bulk off-site collections. Here, we show that a 95% ethanol, safe to be shipped and handled, extraction pipeline recovers comparable amounts of metabolites as a validated 50% methanol extraction, preserving metabolic profiles differences between subjects. Additionally, the fecal metabolome remains relatively stable when stored in 95% ethanol for up to a week at room temperature. Finally, we suggest a metabolomics data analysis workflow using robust centered log ratio transformation, which removes variance introduced by different sample weights, allowing for reliable and integration-ready untargeted metabolomics experiments in gut microbiome studies.
Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms
Authors: May Elizabeth J. , Gaudet Rachelle 
Published: September 2024

AbstractProteins that transmit molecules and signals across the plasma membrane are crucial in cell biology because they enable cells to sense and respond to their surroundings. A major challenge for studying cell-surface proteins is that often they do not fold or traffic properly to the plasma membrane when produced in heterologous cells. We developed a strategy for quantifying surface localization from fluorescence microscopy images of surface-stained cells. Using clustered protocadherins, a protein family important for cell-cell recognition during neuronal development, as a model system, we found that surface delivery levels vary among clustered protocadherin isoforms and between wildtype and engineered variants. Quantifying these differences provides evidence that challenges the generally accepted hypothesis thatcisdimerization controls surface delivery of clustered protocadherins. This work establishes a generalizable framework for screening proteins and variants of interest for proper cell surface localization.SignificanceSurface proteins allow cells to interact with their environments, and their activities are often regulated by their delivery to and removal from the plasma membrane. We developed a strategy to quantitatively compare surface delivery of proteins based on established epitope tag-based surface staining methods. Using natural and engineered variants of clustered protocadherins, cell-surface proteins essential for neuron development, we show that such quantitative comparisons of surface trafficking facilitate the interpretation of mutational effects and can shed light on key regulatory mechanisms. We find that surface trafficking levels differ between variants and that, contrary to what was previously thought, a domain that inhibits surface delivery in some clustered protocadherins may do so independently of its protein-protein interaction interface.
Mother-child dyadic interactions shape children’s social brain and theory of mind
Authors: Li Lei , Xiao Jinming , Zhao Weixing , Zheng Qingyu , Huang Xinyue , Shan Xiaolong , Ming Yating , Wang Peng , Wu Zhen , Chen Huafu , Menon Vinod , Duan Xujun 
Published: September 2024

AbstractSocial cognition develops through a complex interplay between neural maturation and environmental factors, yet the neurobehavioral mechanisms underlying this process remain unclear. Using a naturalistic fMRI paradigm, we investigated the effects of age and parental caregiving on social brain development and Theory of Mind (ToM) in 50 mother-child dyads. The functional maturity of social brain networks was positively associated with age, while mother-child neural synchronization during movie viewing was related to dyadic relationship quality. Crucially, parenting and child factors interactively shaped social cognition outcomes, mediated by ToM abilities. Our findings demonstrate the dynamic interplay of neurocognitive development and interpersonal synchrony in early childhood social cognition, and provide novel evidence for Bandura’s theory of social learning and reciprocal determinism. This integrative approach, bridging brain, behavior, and parenting environment, advances our understanding of the complex mechanisms shaping social cognition. The insights gained can inform personalized interventions promoting social competence, emphasizing the critical importance of nurturing parental relationships in facilitating healthy social development.
New approach to finding invisible states in
e+e−
annihilation and application to BESIII data
Authors: Farrar Glennys R. , Li Qi-Ming , Yuan Chang-Zheng 
Published: September 2024

We compare precision e+e−→μ+μ− cross section measurements by BESIII in the Ecm=3.8–4.6  GeV range, to predictions based on measured Rhad data. The consistency is poor (p-value <0.012). Allowing for resonance contributions not seen in Rhad gives an excellent fit. The 4.6σ state required at 4421 MeV suggests that a substantial portion of ψ(4415) decays are not identified, while the 3.2σ structure at 4211 MeV, if confirmed, points to a new, very narrow resonance. This analysis shows the power of precision e+e−→μ+μ− measurements to uncover or probe otherwise difficult to access states.

Published by the American Physical Society
2024
Measurement of Angular Coefficients of
B¯→D*ℓν¯ℓ
: Implications for
|Vcb|
and Tests of Lepton Flavor Universality
Authors: Prim M. T. , Bernlochner F. , Metzner F. , Aihara H. , Asner D. M. , Aushev T. , Ayad R. , Babu V. , Banerjee Sw. , Behera P. , Belous K. , Bennett J. , Bessner M. , Bhardwaj V. , Bhuyan B. , Bilka T. , Biswas D. , Bodrov D. , Bondar A. , Borah J. , Bračko M. , Branchini P. , Browder T. E. , Budano A. , Campajola M. , Cao L. , Červenkov D. , Chang P. , Cheon B. G. , Choi S.-K. , Choi Y. , Choudhury S. , Cochran J. , Das S. , Dash N. , De Nardo G. , De Pietro G. , Dhamija R. , Di Capua F. , Doležal Z. , Dong T. V. , Dubey S. , Ecker P. , Epifanov D. , Ferber T. , Ferlewicz D. , Fulsom B. G. , Garg R. , Gaur V. , Giri A. , Goldenzweig P. , Gu T. , Gudkova K. , Hadjivasiliou C. , Hara T. , Hayashii H. , Hazra S. , Hedges M. T. , Herrmann D. , Hernández Villanueva M. , Hou W.-S. , Hsu C.-L. , Inami K. , Inguglia G. , Ipsita N. , Ishikawa A. , Itoh R. , Iwasaki M. , Jacobs W. W. , Kiesling C. , Kim C. H. , Kim D. Y. , Kim K.-H. , Kodyš P. , Konno T. , Korobov A. , Korpar S. , Kovalenko E. , Križan P. , Krokovny P. , Kuhr T. , Kumar M. , Kumar R. , Kwon Y.-J. , Lam T. , Lee S. C. , Lewis P. , Li L. K. , Li Gioi L. , Libby J. , Liventsev D. , Ma Y. , Matsuda T. , Matvienko D. , Maurya S. K. , Meier F. , Merola M. , Miyabayashi K. , Mizuk R. , Mohanty G. B. , Nakamura I. , Nakao M. , Narwal D. , Natkaniec Z. , Natochii A. , Nayak L. , Nishida S. , Ono H. , Oskin P. , Pakhlov P. , Pakhlova G. , Park S.-H. , Passeri A. , Patra S. , Pedlar T. K. , Pestotnik R. , Piilonen L. E. , Podobnik T. , Prencipe E. , Röhrken M. , Rout N. , Russo G. , Sandilya S. , Santelj L. , Savinov V. , Schmolz P. , Schnell G. , Schwanda C. , Seino Y. , Senyo K. , Shan W. , Shiu J.-G. , Singh J. B. , Solovieva E. , Starič M. , Stottler Z. S. , Sumihama M. , Takizawa M. , Tanida K. , Tenchini F. , Tiwary R. , Trabelsi K. , Unno Y. , Uno S. , Urquijo P. , Usov Y. , Vahsen S. E. , Varvell K. E. , Vossen A. , Wang M.-Z. , Wang X. L. , Won E. , Yabsley B. D. , Yan W. , Yang S. B. , Yin J. H. , Yuan L. , Zhang Z. P. , Zhilich V. , Zhukova V. ,   Belle Collaboration
Published: September 2024

We measure the complete set of angular coefficients Ji for exclusive B¯→D*ℓν¯ℓ decays (ℓ=e, μ). Our analysis uses the full 711  fb−1 Belle dataset with hadronic tag-side reconstruction. The results allow us to extract the form factors describing the B¯→D* transition and the Cabibbo-Kobayashi-Maskawa matrix element |Vcb|. Using recent lattice QCD calculations for the hadronic form factors, we find |Vcb|=(40.7±0.7)×10−3 using the Boyd-Grinstein-Lebed parametrization, compatible with determinations from inclusive semileptonic decays. We search for lepton flavor universality violation as a function of the hadronic recoil parameter w and investigate the differences of the electron and muon angular distributions. We find no deviation from standard model expectations.

Published by the American Physical Society
2024
Student perspectives on designing and implementing an interprofessional education module in chronic disease management at primary care level in Vietnam
Authors: Nguyen Huyen Thi Thanh , Nguyen Tam Minh , Tsakitzidis Giannoula , Valcke Martin , Nguyen Lo , Nguyen Anh Thi Kim , Ha Nhan Chan , Le Chi Van , Hoang Tien Anh , Vo Toan Duc , Nguyen Tu Minh , Le Anh Ho Thi Quynh , Nguyen Huy Vu Quoc , Wens Johan 
Published: September 2024

PurposeThis study explored students' perspectives on designing and implementing the new clinical interprofessional education (IPE) module for chronic disease management at the primary care level in the Vietnamese context.Design/methodology/approachStudents from seven different university-level healthcare programmes participated in a cross-sectional survey Course Experience Questionnaire-based study. Additionally, two open-ended questions were presented to gather qualitative data, mapping student perspectives. Statistical analyses and thematic analyses were performed.FindingsThe results show that students agree with quality statements about IPE design features, such as good teaching, clear goals and standards, appropriate workload, appropriate assessment and a blended learning approach. Answers to the open-ended comments pointed out the strengths of the IPE module in providing opportunities for interprofessional learning, improving interprofessional collaboration competencies, real-life interprofessional collaboration practice and continuous feedback from tutors. Students also reported weaknesses in the IPE module, including a lack of feedback on the care plan and logistics of the IPE module.Originality/valueStudents positively recognise key design features of the IPE module, combining classroom activities with standardised patient simulations, clinical practice and home visits. Chronic disease management at the primary care level is a suitable context for training students to work interprofessionally. The strengths and weaknesses identified by students could help in the redesign and future implementation of the IPE module in the Vietnamese context. They could inspire practices in Southeast Asian medical education and beyond.
The role of upscale restaurants in destination image formation: a semiotic perspective on gastronomy tourism
Authors: Marine-Roig Estela , Daries Natalia , Cristobal-Fransi Eduard , Sánchez-García Javier 
Published: September 2024

PurposeHigh-end gastronomic tourism is currently trending and significantly impacts a destination’s image. This research aims to demonstrate the importance of high-level local gastronomy in forming the destination image from a semiotic perspective.Design/methodology/approachTo achieve this objective, the three phases of the upscale dining experience – pre-visit, in situ and post-visit – are examined from a descriptive (informative use), appraisive (valuative use) and prescriptive (incitive use) semiotic perspective. This conceptual model includes six constructs: restaurant image, consumer need for status, consumer expectations, consumer satisfaction, restaurant loyalty and destination loyalty. The study is based on a survey of high-end restaurant customers (N = 421).FindingsThe research findings highlight that the characteristics of upscale dining establishments influence customer expectations, while customer satisfaction plays a crucial role in fostering loyalty towards both the restaurant and the destination. Additionally, the study reveals that individuals' social status or reputation moderates their expectations and satisfaction levels.Originality/valueAlthough studies relate gastronomic image to global destination image, this relationship from a semiotic perspective has not been demonstrated through surveys. This proposed three-phase model based on the Peircean semiotic triad and Morris semiotic trichotomies not only addresses a gap in the existing literature but also offers valuable insights for destination managers and restaurant owners.
Economic growth, income inequality and lethal violence in developed countries
Authors: Aransiola Temidayo James , Justus Marcelo , Ceccato Vania 
Published: September 2024

PurposeThe paper aims to investigate the effect of GDP growth on crime and to test the hypothesis of nonlinearity. Additionally, we estimate the interaction between GDP and income inequality and examine its impact on the relationship between GDP and homicide rates.Design/methodology/approachThe study utilizes panel data from the Organization for Economic Cooperation and Development (OECD), spanning the period from 2000 to 2018 and estimates dynamic panel GMM models.FindingsWe found a nonlinear relationship between GDP and homicide rates, indicating a dual effect of GDP on the occurrence of lethal crimes. Moreover, income inequality conditions the effect of GDP on homicide rates, exerting a significant influence. We conclude that in contexts characterized by high levels of income inequality, GDP growth is more effective in reducing crime, as there is greater potential for improvement.Originality/valueThis paper contributes to the existing literature by providing insights into the complex nonlinearity between economic conditions, income inequality and homicide rates.
Gender distributions in New Zealand universities: guilt in Brotopia
Authors: Wang Jenny Jing , Huang Hedy Jiaying 
Published: September 2024

PurposeThe purpose of this study is to explain gender imbalance by theorising how guilt arises as an externally imposed negative emotion that subsequently impairs women's performance in the accounting academia.Design/methodology/approachThe method involves an analysis of gender distributions at junior and senior levels in New Zealand universities in 2019 and 2024 and relevant case studies of junior academics using unstructured interviews.FindingsThis paper unpacks the nuances of gender imbalance in a “gender-neutral” subject and provides empirical evidence that many women academics may internalise a sense of externally imposed guilt for various reasons. Such feelings of guilt, where they are imposed by workplace expectations and social constructions, may make women more concessionary with regard to a greater teaching workload substituting for research expectations. The more prolonged-term effect on career prospects of such substitutions as practiced in New Zealand may account for the imbalance that exists and seemingly will continue to exist.Originality/valueThis paper sets out first to discover the gender balance in accounting in universities in New Zealand. It contributes to the literature on gender and accounting education in understanding how negative emotions are externally imposed and become career-negating obstacles for women in the accounting academic.
Corporate anti-corruption disclosure and earnings management: evidence from East Africa community
Authors: Githaiga Peter Nderitu 
Published: September 2024

PurposeCorruption and earnings management remain a serious concern across the globe. In addition, corporate disclosure of anti-corruption practices is still in its infancy in developing and emerging countries. Therefore, the purpose of this study is to examine the effect of anti-corruption disclosure (ACD) on earnings management (EM) among listed firms in the East Africa Community (EAC) partners states.Design/methodology/approachThe study used an ACD check list developed from recent studies and the Global Reporting Initiative (GRI-205) standard on anticorruption reporting. The sample comprised 58 firms listed across EAC partner states stock/securities exchanges over the period between 2013 and 2022. The hypothesis was tested using the ordinary least squares (OLS) method.FindingsThis study found low level of ACD among the selected firms. The regression results revealed a negative relationship between ACD and EM. The results are robust to alternative panel data estimation methods and a proxy measure of EM.Originality/valueTo the best of the author’s knowledge, this is the first paper that empirically examines the effect of ACD on EM in the EAC, thus making a contribution to the existing literature.
Caribbean libraries 2.0: the robotic revolution in Caribbean academic library spaces
Authors: Duncan Adrian St. Patrick 
Published: September 2024

Purpose
This paper is the genesis for robots and robotic technology and their introduction to the Caribbean Academic library community. This paper aims to explore the specific areas that this technology can improve as well as their adaptability and dynamic yet multifaceted nature it possesses.

Design/methodology/approach
A thorough assessment of literature was done of all developed libraries that are employing the services of robots and robotic technology in their daily operations. Additionally, a meticulous analysis was done of all Caribbean Libraries that have explored, are currently exploring or actively explored the implementation of robots and robotic technology for effective use in their libraries.

Findings
Seamless functionality as well as the reduction of mundane repetitive tasks by library staff is at the fore. Efficacy and heightened levels of accuracy are also found to be a great factor for implementation as well as speed of retrieval and offsite storage are further benefits to the implementation of robots and robotic technology.

Research limitations/implications
This research primarily assessed material on robotics and robotic technology that offers unprecedented efficacy and accuracy in the processing of information and tasks assigned as well as smooth location and retrieval of library material resulting in reduction in wait time for all library users.

Originality/value
To the best of the author’s knowledge, this paper is the first of its kind and is intended to trigger a “light bulb” in the minds of decision-makers and managers of Library spaces as to the potential robots and robotic technology has on fostering greater levels of efficacy in certain key areas of libraries and help improve user services while adding to the theoretical body of knowledge available in the field on this fast rising area.
Perceptions and configurations of balanced scorecard use: evidence from Portuguese SMEs
Authors: Curado Carla , Jesus Maria Miguel , Bontis Nick 
Published: September 2024

Purpose
The purpose of this study is to identify managerial perceptions, as well as individual and organizational contingencies, that influence the use of balanced scorecard (BSC) among SMEs.

Design/methodology/approach
This paper adopts a mixed methods approach to study the use of the BSC from a survey database of 414 SMEs across several industries in Portugal.

Findings
This paper shows the perceived benefits, reasoning and obstacles that managers face when using the BSC in SMEs. The BSC is not the first choice for strategic management control of most firms in the sample. Most SMEs in this study have an explicitly formulated business strategy. The results show that it is possible to implement the BSC in SMEs without a formalized strategy. Such findings seem to suggest that the use of the BSC may stimulate the formulation of strategies for those firms.

Research limitations/implications
The use of fuzzy-set qualitative comparative analysis limits the generalization of the findings; nonetheless, the transparency of the report enables replication without restrictions.

Practical implications
This paper proposes that the size of the firm and the characteristics of the manager may compensate for the absence of a strategy to guide BSC use.

Social implications
This paper advises a match between the stage of development of the SMEs strategy and the gender of the manager, which may have implications for recruitment purposes.

Originality/value
This study reports alternative configurations of individual and organizational conditions that lead to the use of the BSC in SMEs as well as configurations that prevent its use.