bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-tool recipe to identify regions of protein-DNA binding and their influence on associated gene expression
Authors: Carlin Daniel E. , Kosnicki Kassi , Garamszegi Sara , Ideker Trey , Thorvaldsdóttir Helga , Reich Michael , Mesirov Jill P. 
Published: January 2018

One commonly performed bioinformatics task is to infer functional regulation of transcription factors by observing differential expression under a knockout, and integrating DNA binding information of that transcription factor. However, until now, this task has required dedicated bioinformatics support to perform the necessary data integration. GenomeSpace provides a protocol, or “recipe”, and a user interface with inter-operating software tools to identify protein occupancies along the genome from a ChIP-seq experiment and associated differentially regulated genes from a RNA-Seq experiment. By integrating RNA-Seq and ChIP-seq analyses, a user is easily able to associate differing expression phenotypes with changing epigenetic landscapes.
A hidden burden of neonatal illness? A cross-sectional study of all admissions aged less than one month across twelve Kenyan County hospitals
Authors: Murphy Georgina A.V. , Nyakangi Vivian N. , Gathara David , Ogero Morris , English Mike ,   Clinical Information Network
Published: January 2018

Background: Small and sick newborns need high quality specialised care within health facilities to address persistently high neonatal mortality in low-income settings, including Kenya. Methods: We examined neonatal admissions in 12 public-sector County (formerly District) hospitals in Kenya between November 2014 and November 2016. Using data abstracted from newborn unit (NBU) admission registers and paediatric ward (PW) medical records, we explore the magnitude and distribution of admissions. In addition, interviews with senior staff were conducted to understand admission policies for neonates in these facilities. Results: Of the total 80,666 paediatric admissions, 28,884 (35.8%) were aged ≤28 days old. 24,212 (83.8%) of neonates were admitted to organisationally distinct NBUs and 4,672 (16.2%) to general PWs, though the proportion admitted to NBUs varied substantially (range 59.9-99.0%) across hospitals, reflecting widely varying infrastructure and policies. Neonatal mortality was high in NBUs (12%) and PWs (11%), though varied widely across facilities, with documentation of outcomes poor for the NBUs. Conclusion: Improving quality of care on NBUs would affect almost a third of paediatric admissions in Kenya. However, comprehensive policies and strategies are needed to ensure sick neonates on general PWs also receive appropriate care.
Advertising to Early Trend Propagators: Evidence from Twitter
Authors: Lambrecht Anja , Tucker Catherine , Wiertz Caroline 
Published: January 2018

In the digital economy, influencing and controlling the spread of information is a key concern for firms. One way firms try to achieve this is to target firm communications to consumers who embrace and propagate the spread of new information on emerging and “trending” topics on social media. However, little is known about whether early trend propagators are indeed responsive to firm-sponsored messages. To explore whether early propagators of trending topics respond to advertising messages, we use data from two field tests conducted by a charity and an emerging fashion firm on the microblogging service Twitter. On Twitter, “promoted tweets” allow advertisers to target individuals based on the content of their recent postings. Twitter continuously identifies in real time which topics are newly popular among Twitter users. In the field tests, we collaborated with a charity and a fashion firm to target ads at consumers who embraced a Twitter trend early in its life cycle by posting about it, and compared their behavior to that of consumers who posted about the same topic later on. Throughout both field tests, we consistently find that early propagators of trends are less responsive to advertising than consumers who embrace trends later. Data and the online appendix are available at https://doi.org/10.1287/mksc.2017.1062 .
La modernidad en Valencia a través de tres obras del arquitecto Mauro Lleó.
Authors: Martínez Gregori Carmen 
Published: January 2018

Después del estancamiento a nivel urbanístico que supuso la etapa autárquica, comenzó el verdadero “boom” urbano que doblaría el área urbanizada de la ciudad de Valencia. A partir de la solución estructural radio-concéntrica que planteaba el PGOU de 1946, se establecieron los nuevos ejes del desarrollo tanto urbanos como industriales, siendo el del oeste, el de Manises-Quart de Poblet-Aldaia, el especializado en la industria metálica.Pero el Plan no era viable sin una red de vías radiales que dieran a los caminos históricos la proporción adecuada a su nueva condición. Este es el caso del Camí Reial de Castilla que en el año 1953 se abría al tránsito, convirtiéndose en la nueva entrada de la carretera de Madrid a la ciudad de Valencia y la conexión con el aeropuerto de Manises.Se creaba así un gran eje comercial e industrial a lo largo del cual se instalarían grandes empresas dadas sus buenas comunicaciones con la capital del Estado. Es el caso de la embotelladora Coca-Cola (1958), de la fábrica de transformados metálicos FLEX (1961) o de la filial de S.E.A.T (1965), edificios todos obra del mismo arquitecto, Mauro Lleó Serret (1914-2001), y que se convirtieron en pioneros de la modernidad en la ciudad.La planta de embotellar Coca-Cola, aún siendo deudora de los modelos de Gutiérrez-Soto en cuanto a materiales, juega en su composición con volúmenes sencillos de una o dos plantas que macla con acierto relacionando el programa que contienen. La fábrica FLEX es un edificio industrial en altura que muestra en fachada la retícula estructural que lo sostiene que, aunque todavía de hormigón, se confirma como recurso compositivo que va acercando al arquitecto a las soluciones constructivas miesianas y finalmente, el edificio para S.E.A.T. constituyó un paso hacia la construcción estandarizada y la prefabricación, aunque todavía con recelos, en la solución de sus fachadas a base de muros cortina, brise-soleil y marquesinas metálicas.
Influencia de los parámetros de diseño en el éxito del espacio público. Hacia una reconversión de los procesos de proyecto pensando en las personas.
Authors: Melgarejo Torralba Maria del Mar 
Published: January 2018

El espacio público es una morfología urbana que nos permite observar, medir, contar, analizar y así obtener respuestas objetivas y concretas. Es el emblema de la ciudad, la base de nuestra sociabilidad. El diseño urbano ha tenido poca influencia en el uso cotidiano que de él hacen los habitantes de la ciudad, por lo tanto determinar el porqué de su éxito permite conectar con los más directos beneficiarios: los ciudadanos. El objetivo de esta investigación es entender la influencia del diseño urbano en el éxito del espacio público, entendiendo como éxito un lugar en pleno uso, lleno de actividad y que se convierta en un escenario social donde encontramos a mucha gente interactuando, en grupos de personas, charlando, sonriendo, usando ese espacio con regularidad y voluntariamente. Para ello se propine una metodología de análisis donde la ciudad de Cartagena, paradigma de la ciudad costera militar, se convierte en un laboratorio urbano, y estudiamos los espacios públicos de su casco histórico como un tejido urbano que aglutina diferentes condiciones urbanísticas históricas y morfológicas que podríamos considerar similares y que nos permite poder comparar.El resultado de este análisis concluye que la incidencia del diseño y la morfología de un espacio público es menor que las numerosas variables contextuales que influyen sobre él. Esto pone de manifiesto la necesidad que desde la disciplina de la arquitectura y el urbanismo hay de escuchar más a los ciudadanos y a los futuros “clientes” de los espacios que se proponen, y se hace necesario revertir el proceso de pensamiento de los espacios urbanos hacia una manera de construir más cercana.
Pedagogia Hospitalar no Hospital Municipal de Tangará da Serra - MT
Authors: Silva Maria Sônia , Pereira Lilian Rebecca , Dallastra Maurício , Brescovit Luiz Eduardo 
Published: January 2018

A pesquisa foi realizada na brinquedoteca do Hospital Municipal de Tangará da Serra – MT, com objetivo de compreender as aplicações de práticas pedagógicas proporcionadas pelo profissional Pedagogo na ala pediátrica do Hospital Municipal. Os aspectos metodológicos foram pautados na abordagem qualitativa, através da coleta de dados por meio de entrevistas, com perguntas abertas, direcionadas as crianças hospitalizadas e seus acompanhantes. As perguntas foram gravadas com um celular, após a coleta as entrevistas passaram pelo processo de transcrição respeitando na íntegra a linguagem de cada um dos entrevistados. O resultado do trabalho pedagógico indicou melhora do aspecto social e possibilidade de internação entre crianças e acompanhantes na ala pediátrica, gerando alegria possibilitando a criança um pouco de divertimento no período de internação. As atividades foram vistas como um momento de distração para os internos e seus acompanhantes, proporcionando a criança um lugar mais prazeroso no decorrer do tratamento através da pedagogia hospitalar.
The functional role of microRNAs in laryngeal carcinoma
Authors: Cheng Jinzhang , Chen Junjun , Wang Zonggui , Yu Dan , Zu Yuanzhang 
Published: January 2018

AbstractMicroRNAs are a class of non-coding, small RNAs, which modulate gene expression at the post-transcriptional level. Numerous studies have showed microRNAs are involved in the pathogenesis of laryngeal cancer through regulating tumor-related genes such as oncogenes or tumor suppressor genes. In this review, we summarize recent progress on the function of microRNAs in laryngeal cancer. We focus on potential use of microRNAs in laryngeal cancer diagnosis and prognosis.
Where metaphorsreallycome from: Social factors as contextual influence in Hungarian teenagers’ metaphorical conceptualizations of life
Authors: Benczes Réka , Ságvári Bence 
Published: January 2018

AbstractWhen it comes to metaphorical conceptualizations of life, previous cognitive linguistic research has identified cultural history as the single most important factor in the selection of the source domain. Accordingly, Hungary had to constantly battle for survival, prompting Hungarians to think of life primarily in terms of struggle and compromise, resulting in a more negative mindset towards life. We investigated the validity of this claim by drawing on a nationwide survey of Hungarian teenagers. Three main findings of the research are presented in the paper. First, the identified metaphors were of a general character and no particularly prevalent, negative conceptualizations emerged; Hungarian teenagers conceptualize life primarily asgame, food, journey, challenge, plantandrollercoaster. Second, social factors – type and location of school, socio-economic status and media consumption – can have an effect on the selection of source domains, thus lessening the importance of cultural history in shaping metaphorical conceptualizations of life. Third, social factors influence speakers’ overall inclination toward metaphorical usage. Our results suggest that inclination to verbalize metaphorical conceptualizations is not all-pervasive throughout the whole linguistic community, but is constrained by type of school (at the secondary level), mother’s level of education, academic performance and reading habits.
Bias wanted! Examining people’s information exposure, quality expectations and bias perceptions in the context of the refugees debate among different segments of the German population
Authors: Arlt Dorothee , Wolling Jens 
Published: January 2018

AbstractThe growing number of refugees entering Europe since 2015 has quickly ignited a heated public debate on refugees in Germany. Against the backdrop of the media’s information and opinion-forming function, this paper examines the importance of mainstream and social media among different segments of the German population. Applying cluster analysis to survey data (n= 1,579), six clusters with specific attitude-behavior combinations concerning the refugee issue were identified: Pro-Refugee Activists, Passive-Affirmative Mainstream, Directly-Involved Ambivalents, Passive-Worried Mainstream, Worried Agitators, and Anti-Refugee Activists. The results show that these clusters differ both in terms of socio-demographic and political characteristics as well as in terms of people’s issue-specific media usage, expectations, and evaluations of media coverage. Moreover, the findings indicate that social media play a problematic role in the debate as they seem to reinforce people’s pre-existing attitudes toward refugees. The implications of these findings for public debate on refugees are also discussed.
The effects of visual isolation on the perception of scandalized politicians
Authors: Sikorski Christian von , Ludwig Mark 
Published: January 2018

Abstract
In their depictions of scandalized politicians, journalists frequently use news images that highlight the (alleged) isolation of
politicians. To test how this way of portraying political actors affects a recipient’s attitudes and his/her guilt perception toward
such a scandalized politician an experiment was conducted. All participants were exposed to the identical textual information.
However, the visual information (degree of isolation) was systematically altered. A multivariate analysis of covariance (MANCOVA)
showed that participants – exposed to a visual highlighting the isolation of the politician – evaluated the politician in a significantly
more negative way and rated other recipients’ perceptions of the politician’s level of guilt to be higher.
“Beef Jerky in a Ball Gown”: The Camp Excesses of Titus Andromedon in Unbreakable Kimmy Schmidt
Authors: Dexl Carmen , Horn Katrin 
Published: January 2018

Abstract
In this essay, we look at Titus Andromedon from the Netflix-sitcom Unbreakable Kimmy Schmidt (2014-) as a singular phenomenon in contemporary TV: a black queen whose use of camp distances him from stereotypes, but connects him with audiences. Titus thus not only adds to a more diverse representation of black experience on TV but also interrogates prevailing TV tropes. Titus thus presents a crucial (and critical) addition to the contemporary TV landscape, to which several TV critics in leading media outlets have recently attested a turning point in the representation-both in quantity and quality-of black characters on big and small screens. Titus breaks with historical traditions of African American representation in the sitcom, both in so-called “black sitcoms” with a majority of African American characters and in white sitcoms which have featured people of color as sidekicks. In addition, Titus picks up on gay sidekicks and their relation to female lead characters, whose dynamics are interrogated through Titus’s growing agency as a character in his own right. Titus expands on these novelties in meaningful ways, as he wholeheartedly embraces his queer identity and furthermore offers a running commentary on other characters’ “white nonsense,” thereby clearly refusing the assimilationist tendencies typical for much of “Post-Cosby”-sitcom black representation. This article therefore claims that Titus’ character relies on camp in his balancing act between comic relief, affective centering, and critical distance, and illustrates this by analyzing the specific techniques of Titus’ critical engagement with stereotypical representation of gay and black TV characters.
Enhancement of Catalytic Performance of H-Clinoptilolite in Toluene Abatement from Polluted Air via Controlled Dealumination Method
Authors: Ghasemian Naser , Yousefi Ali Reza 
Published: January 2018

AbstractIn this study, the effect of clinoptilolite dealumination on the total oxidation of toluene was reported for the first time. To avoid excess decrease of catalyst crystallinity, chemical modification of zeolite was carried out using a mild acid like oxalic acid. The catalysts were characterized by XRD, XRF, SEM, BET and TPD analyses. It was found that dealumination resulted in a significant enhancement of toluene conversion when 0.050 M acid oxalic was used for a treatment period of 2 h. Dealumination substantially changed the distribution of the concentration of acid sites of different strength and increased the surface area and porosity, so that the temperature corresponding to the maximum conversion shifts around 50 °C towards lower temperatures (in case of CLP 050). The effect of dealumination on the activity of the zeolite samples and the total oxidation of toluene was discussed in terms of Si/Al ratio, crystallinity, distribution of acid site strength and textural characteristics of the samples.
Estimated Time of Restoration (ETR) Guidance for Electric Distribution Networks
Authors: Wanik David , Anagnostou Emmanouil , Hartman Brian , Layton Thomas 
Published: January 2018

Abstract
Electric distribution utilities have an obligation to inform the public and government regulators about when they expect to complete service restoration after a major storm. In this study, we explore methods for calculating the estimated time of restoration (ETR) from weather impacts, defined as the time it will take for 99.5% of customers to be restored. Actual data from Storm Irene (2011), the October Nor’easter (2011) and Hurricane Sandy (2012) within the Eversource Energy-Connecticut service territory were used to calibrate and test the methods; data used included predicted outages, the peak number of customers affected, a ratio of how many outages a restoration crew can repair per day, and the count of crews working per day. Data known before a storm strikes (such as predicted outages and available crews) can be used to calculate ETR and support pre-storm allocation of crews and resources, while data available immediately after the storm passes (such as customers affected) can be used as motivation for securing or releasing crews to complete the restoration in a timely manner. Used together, the methods presented in this paper will help utilities provide a reasonable, data-driven ETR without relying solely on qualitative past experiences or instinct.
Mathematical and computational studies of fractional reaction-diffusion system modelling predator-prey interactions
Authors: Owolabi Kolade M. , Pindza Edson 
Published: January 2018

AbstractThis paper provides the essential mathematical basis for computational studies of space fractional reaction-diffusion systems, from biological and numerical analysis perspectives. We adopt linear stability analysis to derive conditions on the choice of parameters that lead to biologically meaningful equilibria. The stability analysis has a lot of implications for understanding the various spatiotemporal and chaotic behaviors of the species in the spatial domain. For the solution of the full reaction-diffusion system modelled by the fractional partial differential equations, we introduced the Fourier transform method to discretize in space and advance the resulting system of ordinary differential equation in time with the fourth-order exponential time differencing scheme. Numerical results.
Absent Pulmonary Valve Syndrome – Special Prenatal Care and Early Surgery in Obstetric/Cardiac Center - A New Hope for Postnatal Survivors?
Authors: Zych-Krekora Katarzyna , Krekora Michał , Kopala Marek , Respondek-Libserska Maria 
Published: January 2018

Abstract
Introduction: APVS (Absent Pulmonary Valve Syndrome) is a rare congenital heart disease. Its incidence according to The Polish National Registry of Fetal Cardiac Pathology in years 2004 - 2016 was 0.6%.This disease is caused by the absence or the residual pulmonary artery valve resulting in significant dilation of the pulmonary trunk and its branches. In utero deaths are reported. After birth the major problem is respiratory failure and high preoperative and postoperative mortality. Material and methods: In 1995 to 2016, 11 fetuses with APVS were diagnosed in our unit, at the average 27,5 weeks of gestation (min. 18.5- max 37.1 weeks of gestation). Two groups were analysed in this series of cases: “Old one” by 2011 (n = 6) and “New one” since 2011 (n = 5) and perinatal care as well as survival were compared. We analysed the fetal echo results, perinatal care including transplacental digoxin and steroids treatment in NEW group, the longevity of the pregnancy and neonatal/infants outcome. Results: In Old group the average day of cardiac surgery was day 91st after birth (max. 161) and the survival was 50% . In the New group the average surgery day was 41st day and the postoperative survival was 60%, however there was no statistical significance ( p > 0,05). Conclusions: There is no single parameter from prenatal life in foetuses with APVS which may allow to predict the positive outcome meaning neonatal survival. However optimal perinatal care (early detection of defect, transplacental digoxin at least 3-4 weeks, steroids, no preterm delivery, on-time delivery, postnatal care in tertiary center) and relatively early cardiac surgery may have combined impact on the improvement of survival after prenatal diagnosis of APVS, however more data are necessary to prove this hypothesis.
Recommendations for Prenatal Echocardiography: A Report from International Prenatal Cardiology Collaboration Group.
Authors: Murlewska Julia , Słodki Maciej , Axt-Fliender Roland , Rizzo Giusseppe , Sklansky Mark , Weiner Stuart , Blickstein Isaac , Respondek-Liberska Maria 
Published: January 2018

AbstractInternational Prenatal Cardiology Collaboration Group (IPCCG) links specialists from prenatal cardiology all over the world. In this recommendation we would like to focus on the fetal/prenatal echocardiography official report. So far many recommendations focused mainly on technical aspects of the fetal heart examination.
Effects of nano-silicon dioxide surface modification on the morphology and mechanical properties of ABS/PMMA blends
Authors: Ding Jin , Yue Zhenming , Sun Jiao , Gao Jun 
Published: January 2018

Abstract
This work analyzed the effects of nano-silicon dioxide (nano-SiO2) fillers on the morphology and mechanical properties of acrylonitrile-butadiene-styrene (ABS)/poly(methyl methacrylate) (PMMA) blends. Nano-SiO2 particles were selectively dispersed in the PMMA phase, and the toughness of the ternary blends was significantly improved when the contents of the nano-SiO2 fillers were below 2 wt%. The stearic acid treatment of nano-SiO2 particles prevented the adhesion between constituents and markedly diminished the toughness of the blends. Nano-SiO2 particles were alternatively treated with a silane coupling agent to promote adhesion. The toughness was better in blends for filler contents below 2 wt% than in pure nano-SiO2 particles. However, the presence of nano-SiO2 fillers decreased the surface glossiness of the blends. This work provides new insights into the processes by which nanomaterials toughen ABS/PMMA blends.
Entschließung der HRK zu primärqualifizierenden Studiengängen in Gesundheitsfachberufen
Authors: Blättner Beate 
Published: January 2018

Zusammenfassung
Die Hochschulrektorenkonferenz (HRK) fordert Änderungen der berufsrechtlichen Regelungen der Gesundheitsfachberufe, um eine primärqualifizierende Ausbildung an Hochschulen in Deutschland für einen Teil der jeweiligen Berufsgruppe zu erleichtern. Die praktische Ausbildung soll an Universitätskliniken oder akademischen Lehrkrankenhäusern erfolgen. Die Forderungen der HRK werden nur bedingt zu einer Verbesserung der Qualität der Gesundheitsversorgung führen, zumindest nicht im ambulanten Bereich.