bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organization of rehabilitation for reproductive system malignant neoplasms
Authors: Aleksandrov A. G. 
Published: September 2024

Background. The advances in medicine have significantly improved the life expectancy for patients with gynecologic oncology. Currently, one of the key tasks of the healthcare system is to restore and maintain the quality of life of cancer patients, which actualizes the issues of optimizing the rehabilitation system.Objective: to present the features of organizing rehabilitation activities for female patients with gynecological oncological diseases.Material and methods. The review included 75 Russian and English publications found in the scientific databases PubMed/ MEDLINE, Google Scholar, ScienceDirect and online libraries eLibrary, CyberLeninka, Cochrane Library as well as on websites of scientific communities and organizations. The selection of publications was carried out according to PRISMA recommendations.Results. The procedure for providing rehabilitation care to patients of oncogynecological profile is similar in some aspects to that of other oncological diseases. The effectiveness of nutritional support, therapeutic physical culture, physiotherapy and psychological assistance in restoring quality of life and preventing the development of complications was demonstrated. In case of distress, deep negative psycho-emotional manifestations affecting the physiological processes of the body, yoga, art therapy, cognitive-behavioral therapy, hypnotherapy, occupational therapy and dance-movement therapy exert a good effect. However, rehabilitation in patients with oncological diseases of reproductive organs has a number of features: it is necessary to monitor the state of their sexual function and the development of pain syndrome. Besides, there is a request for personalized rehabilitation assistance. This specificity is related to changed hormonal status, complications after surgery and the patients’ closeness in discussing sexual health issues.Conclusion. Rehabilitation of women after treatment for oncogynecological diseases restores lost well-being, however, current measures of support are not enough. The provision of comprehensive personalized rehabilitation to such patients in Russia is not mandatory, which affects the duration and effectiveness of their health restoration. Further development of rehabilitation care, including through widespread implementation of comprehensive rehabilitation, will improve its quality and reduce the financial burden on the healthcare system.
Regional, local and current forecast of the impact hazard of coal seam sites based on seismic monitoring
Authors: Razumov Egor E. , Prostov Sergey M. , Shabanov Evgeny A. 
Published: September 2024

Relevance. Insufficient validity of the quantitative criteria of the regional, local and current forecast of the impact hazard of the coal seams being developed, the absence of algorithms linking the use of geophysical and direct geomechanical methods in forecasting. Aim. To develop a comprehensive method of geodynamic forecasting, including determining the extent of an impact-prone area identified by the results of a regional forecast based on the registration data of the GITS seismic monitoring system, for conducting local and current forecasts of impact hazard by regulatory methods. Object. An array of rocks of the excavation column 4-1-5-7 of the Osinnikovskaya mine during mining operations in the zone of a group of tectonic disturbances and the intersection of advanced workings. Methods. Regional geomechanical forecast by the geophysical method of seismic activity registration (GITS system), local (current) forecast by natural electromagnetic radiation methods (Angel-M equipment) and the output of drilling fines. Results. The paper introduces the results of complex studies in the excavation column 4 1-5-7 of the Osinnikovskaya mine to establish a correlation between seismic activity and the parameters of the stress-strain state of the array. The authors have introduced the concept of integral indicators of the considered parameters IF and Ikσ. They take into account the area of the zone for the i-th range according to the complex parameter of seismic activity F and the coefficient of vertical stresses in the roof of the formation Kσ. It is established that the informative value of the integral indicators is almost twice as high as the informative value of the initial parameters. Experimental nomograms и are presented to determine the category "DANGEROUS/NON-DANGEROUS" for the regional forecast of impact hazard according to the GITS seismic monitoring system. The authors developed a general algorithm for predicting the impact hazard during clean-up operations. This algorithm uses an integrated approach that includes a regional forecast for recording seismic activity within the mine field and local forecasting methods, both geophysical and direct, to clarify the boundaries of seismic energy release zones and confirm the category of impact hazard. Thу paper introduces the example of determining the width of the zone of increased seismic energy release in the mine closest to the seismically active zone. The dynamics of the occurrence, development and decrease of the seismic energy release zone in the considered areas in the mine workings is shown. The authors give the examples of the implementation of a local forecast of impact hazard in previously established potentially dangerous areas by methods of recording natural electromagnetic radiation of rocks and by the output of drilling fines.
Pengaruh Model Pembelajaran CORE dengan Metode Problem Posing terhadap Kemampuan Pemecahan Masalah Matematika Siswa Kelas VIII SMP di Lubuklinggau
Authors: Sari Ratna 
Published: September 2024

ABSTRACT

This study aims to determine the effect of CORE learning model by the method of Problem Posing on mathematical problem solving ability at the eighth grade students of SMP Ar Risalah Lubuklinggau in academic year 2019/2020. The research method used in the form of pure experimentation. The population in this study were all students of class VIII SMP Ar Risalah Lubuklinggau the academic year 2019/2020, which consists of 157 students and a sample is VIII.Ibnu Khaldun as an experimental class and VIII.Ibnu Miskawaih as the control class. Collecting the data in the study used a test about the description. The data were analyzed using t-test. Based on the analysis of t-test with a significant level of = 0.05, obtained thitung (1,81) > ttabel (1,67), so it can be concluded that there is influence learning model CORE method Problem Posing on mathematical problem solving ability at the eighth grade students of SMP Ar Risalah Lubuklinggau in academic year 2019/2020. From the results of post-test the average score of students' mathematical problem solving ability in the experimental class was 23.52 and in the control class was 14.45.

Keywords: CORE, Problem Posing, Problem Solving.

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ABSTRAK

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran CORE dengan metode Problem Posing terhadap kemampuan pemecahan masalah matematika siswa kelas VIII SMP Ar Risalah Lubuklinggau tahun pelajaran 2019/2020. Metode penelitian digunakan berbentuk eksperimen murni. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMP Ar Risalah Lubuklinggau tahun pelajaran 2019/2020, yang terdiri dari 157 siswa dan sebagai sampelnya adalah kelas VIII.Ibnu Khaldun sebagai kelas eksperimen dan kelas VIII.Ibnu Miskawaih sebagai kelas kontrol. Pengumpulan data dalam penelitian menggunakan tes soal uraian.. Data yang terkumpul dianalisis menggunakan uji-t. Berdasarkan hasil analisis uji-t dengan taraf signifikan sebesar = 0,05, diperoleh thitung (1,81) > ttabel (1,67), sehingga dapat disimpulkan bahwa ada pengaruh model pembelajaran CORE dengan metode Problem Posing terhadap kemampuan pemecahan masalah matematika siswa kelas VIII SMP Ar Risalah Lubuklinggau tahun pelajaran 2019/2020. Dari hasil post-test rata-ratas skor kemampuan pemecahan masalah matematika siswa pada kelas eksperimen sebesar 23,52 dan pada kelas kontrol sebesar 14,45.

Kata kunci: CORE, Problem Posing, Pemecahan Masalah.
COVID-19 Vaccination in Autoimmune Patients: A Literature Review
Authors: Wardhany Atiqah Nurul , Awalia  , Setiabudi Rebekah J 
Published: September 2024

Patients with autoimmune diseases, especially rheumatic diseases, have their own concerns regarding the coronavirus disease 2019 (COVID-19) vaccination. Their concerns are specifically related to the physicological response, side effects, and effectiveness of the COVID-19 vaccination. COVID-19 and autoimmune diseases share some similarities in their clinical manifestations, immune responses, and pathogenic mechanisms. The correlation between COVID-19 vaccination and autoimmune diseases can be attributed to epitope mimicry, where the antigen contained in the vaccine has a structural similarity to self-antigen. The purpose of this literature review was to discuss the various types of vaccines, the side effects of the COVID-19 vaccination, and the effect of autoimmune patients' medication on the administration of the COVID-19 vaccination. According to several articles obtained in this study, most autoimmune patients typically experienced mild to moderate side effects. It was not advised for these patients to stop treatment before receiving the COVID-19 vaccination, as doing so was unlikely to affect the vaccine's effectiveness or the patients' immune response. The condition of the autoimmune patients was what influenced the immune response mediated by antibodies. Therefore, the COVID-19 vaccination must be administered when the patients are in a stable condition. In conclusion, it was determined that there is no restriction preventing autoimmune patients from receiving the COVID-19 vaccination. However, it should be noted that autoimmune patients are not recommended to receive live vaccines.

Highlights:

This study reviewed the concerns of autoimmune patients over the side effects of the COVID-19 vaccination on their prescribed medication.
It is advisable for autoimmune patients to refrain from obtaining live-attenuated vaccines because of their potential effect on the immune response.
Shift Work and Associated Health Consequences: A Review
Authors: Burooj Ahmed 
Published: September 2024

This literature review aims to examine the complex relationship between engaging in shift work and its subsequent health sequelae, while also shedding light on fields of research that require further investigation. Indexing services (i.e., Scopus and PubMed) were used to identify pertinent studies, prioritizing original research, review articles, and meta-analyses from 2018 to 2023. Papers not published in English or where full-text translation was not available, research conducted solely on non-human populations, as well as proposal and opinion papers, were excluded. Papers published before 2018 and those with a sample size of 50 participants or fewer were also omitted. The author conducted a thorough evaluation of each study to ensure its relevance and significance. After deduplication of the search results and implementation of the exclusion criteria, 51 papers were shortlisted for this review. The keywords used for the literature search were “shift work”, “health”, “night shift”, “cardiovascular”, “circadian, cancer”, “disease”, “dose-response relationship”, and “long working hours”. The results showed that shift work significantly impacts various aspects of health, presenting risks in the areas of cardiovascular health, cancer susceptibility, circadian rhythm, immunity, metabolism, reproductive health, and mental well-being. Shift workers have increased risks for diabetes, hypertension, adverse cardiac events, circadian dysrhythmia, metabolic syndrome, mental health disorders, and even certain types of cancer. Shift work exhibits significant associations with sexual and reproductive dysfunction in both sexes, including elevated risks for miscarriages and preterm birth. In conclusion, the findings underscore the need for comprehensive health interventions and further research to understand the intricate relationships between shift work and long-term health consequences.

Highlights:

Disruption of circadian rhythm due to shift work contributes to various health issues, including altered melatonin levels, immune dysfunction, and metabolic disturbances.
There is a critical need for longitudinal studies to explore interventions and workplace policies that can mitigate the adverse health effects of shift work.
Addressing the multifaceted impact of shift work on health requires a holistic approach that considers factors like circadian rhythm optimization, workplace support, and tailored interventions.
Revealing Microstructure and Enduring Properties of Settled Barite Extracted from an Offshore Well Two Decades Later: Well Abandonment and Slot Recovery
Authors: Yousuf H. B. , Khalifeh M. , Saasen A. , Godøy R. , Karlsen H. C. , Naumann M. , Ibragimova Z. , Kruber C. , Noort R. V. 
Published: September 2024

Summary
Barite settling in the annulus behind the casing is an undesired yet common occurrence during the life of a well. Over time, the drilling fluid left in the annulus settles, leaving behind solidified barite that can hinder slot recovery and plug and abandonment (P&A) operations by impeding the cut and pull process. During a P&A operation, Equinor acquired settled barite samples from a North Sea well where the casing was held back by these weighting agents, introducing overpull and prolonging the cut and pull operation. A laboratory analysis program that included determination of the particle-size distribution (PSD), electrokinetic potential of particles (zeta potential), crystallography [X-ray diffraction (XRD)], chemical composition [X-ray fluorescence (XRF)], thermogravimetric analysis (TGA), and microstructure [scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and quantitative evaluation of materials by scanning electron microscopy (QEMSCAN)] was carried out on these settled barite samples to understand their properties. The results of this study provided valuable insights into the composition and characteristics of the settled material in the annulus. The solidified barite within the annular space exhibited no signs of chemical reactions. XRD analysis confirmed the barite to be the sole predominant solid in the solidified material, aligning with expectations. However, additional analytical techniques, including XRF, QEMSCAN, and EDS, detected interconnections between barite particles, primarily facilitated by iron or quartz particles. Additionally, trace amounts of calcite, iron oxide, and mixed compositions involving Si, S, Fe, Ba, O, and Cl were identified within the solidified material. SEM results indicated that the particles exhibited strong compaction characteristics but lacked cementation, retaining some porosity. Notably, the absence of bentonite or other clays was consistently observed in all analyses. This study highlights the process of solidification observed in settled barite, suggesting that factors other than chemical reactions may be responsible for this phenomenon. The potential mechanisms contributing to solidification include physical aggregation, compaction, and alterations in surface charge under downhole conditions. This enhanced understanding of the solidification process will contribute to the development of solutions for efficient casing removal and even the usage of settled barite as a barrier material.
A Machine Learning Approach to Predict Blood Cancer from Patients' Symptoms and Blood Images
Authors: Akter Tanjina , Ghosh Kingkar Prosad , Rabbi Ahmed , Rahman Mohammad Motiur , Rume Marufa Jahan 
Published: September 2024

Abstract

This article presents a novel investigation into the detection of blood cancer and its subtypes using machine learning (ML) algorithms, with a specific focus on patient symptoms and microscopic blood images. Early diagnosis of blood cancer poses significant challenges and potential life-threatening consequences, primarily due to the complexities involved in identifying subtypes prevalent among both adults and children. This study delves into the rapid advancements in ML technologies and their applications in cancer research. Over the past decade, ML algorithms have demonstrated considerable promise in early cancer testing and have seen increased adoption in cancer diagnosis. In this research, we utilize a comprehensive ensemble of ML classifiers, including Naive Bayes, K-Nearest Neighbor, Support Vector Machine, Decision Tree, and Random Forest, to classify patient symptoms. Furthermore, state-of-the-art classifiers such as CNN, VGG, Inception, KNN, SVM, Random Forest, and Naïve Bayes distinguish between healthy and unhealthy cells in microscopic blood images. Our study's results showcase the highest accuracy achieved for the symptoms determination model using the Random Forest classifier at 85%. Additionally, microscopic image analysis demonstrates an accuracy of 97% using the Efficient Net b3 detection model. The novelty of this research lies in its pioneering approach to disease detection by integrating advanced ML algorithms to analyze both patient symptoms and microscopic images. By offering valuable insights and achieving a substantial step forward in the quest to combat blood cancer effectively, these findings contribute to the field of medical research. The integration of machine learning into cancer detection has the potential to transform the medical landscape, providing better patient outcomes and improving overall healthcare practices.
Genetic Insights into Associations Between Bowel Diseases and Chronic Kidney Disease by Two-Sample Mendelian Randomization
Authors: Li Xinming , Xu Jiayu , Zhou Chenchen , Lv Jiayi , Xu Jing , Zhang Liming , Mao Zhiguo , Liu Zhijia , Xue Cheng , Tai Hongqin 
Published: September 2024

Abstract

Objective
This study aims to investigate the genetic causal relationships between gastrointestinal diseases—specifically celiac disease (CeD), and inflammatory bowel disease (IBD)—and chronic kidney disease (CKD).
Methods
We conducted a two-sample Mendelian randomization (MR) analysis using publicly available genome-wide association studies (GWAS) data. Two sets of single-nucleotide polymorphisms (SNPs) were chosed as instrumental variables(IVs), 32 SNPs related with CeD and 68 SNPs associated IBD. The primary analysis utilized the inverse variance weighted (IVW) method, supplemented by MR-Egger and weighted median approaches.
Results
Our findings indicate significant genetic causal effects of CeD and IBD on the risk of developing CKD. The IVW method showed a positive association between CeD and CKD (OR = 1.021, 95% CI = 1.002–1.041, P = 0.032), with stronger effects observed for IBD (OR = 1.051, 95% CI = 1.014–1.089, P = 0.006). Reverse MR results of CKD on CeD (P = 0.435; OR = 0.939) and CKD on IBD (P = 0.166; OR = 1.120) were not statistically significant.
Conclusions
The study provides genetic evidence linking gastrointestinal diseases to an increased risk of CKD. These findings highlight the importance of considering genetic predispositions when assessing CKD risk in patients with CeD and IBD.
Unlocking the biocontrol and plant growth potential of endophytic fungi against pea root rot complex in Himachal Pradesh, India
Authors: Kushwaha Kavita , Pal Joginder , Banyal Devinder K , Paul Surinder , Katoch Gaurav 
Published: September 2024

Abstract

Pea root rot complex (PRRC) incited by plethora of fungal and oomycetous pathogens is often ratified as a major hitch and yield declining factor to world pea production. In this study, we have isolated fifty one endophytic fungi from healthy pea roots collected from the sub-humid and dry temperate regions of Himachal Pradesh, India. Of these, eight potent fungi exhibiting higher antagonism through preliminary screening were assessed for their antagonism against most predominant PRRC pathogen Fusarium oxysporum using the dual culture test. Under in vitro screenings, maximum mycelial inhibition of 82.22% was obtained with the Schizophyllum sp. isolate JPE19. Microscopic illustrations traced from interaction zone of endophyte and target pathogen displayed conspicuous aberration in the hyphae of pathogen. Under glasshouse and field evaluation assay, maximum per cent disease control was achieved in treatment Schizophyllum sp. isolate JPE19 exhibiting 79.42 and 74.29% disease control, respectively. Further, it has remarkably augmented the growth traits of pea under both glasshouse and field conditions. Root colonization executed by plate count and confocal microscopic analysis substantiated significantly higher colonization in endophytes treated plants which affirmed the establishment of inoculated strain in endosphere of the pea plants. The data retrieved in current research to the best of our knowledge witnesses first report on biocontrol and plant growth promoting potential of pea inhabited endophytic fungi and furthers our route to develop commercial bio-formulation of these fungi which could be used as green option for effective management of dreadful PRRC disease.
Bulk RNA analysis identified the characteristics and immunoinvasive patterns of osimertinib resistance in patients with non-small cell lung cancer
Authors: Shi Ling , Qiu Feng , Shi Chao , Zhang Guohua , Yu Feng 
Published: September 2024

Abstract

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, with epidermal growth factor receptor (EGFR) mutations being a common driver. Osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), has shown efficacy in treating NSCLC patients harboring EGFR mutations. However, resistance to osimertinib poses a significant clinical challenge. This study aims to identify key genes associated with osimertinib resistance in NSCLC and elucidate their underlying mechanisms to inform new therapeutic strategies. Utilizing a comprehensive bioinformatics approach, we conducted differential expression analysis, enrichment analysis, consensus clustering, drug sensitivity analysis, protein-protein interaction (PPI) network construction, and immune infiltration analysis. Our findings revealed 126 genes, including KRT14, KRT16, KRT17, KRT5, KRT6A, KRT6B, TP63, and TRIM29, that are potentially pivotal in osimertinib resistance. Enrichment analyses indicated significant involvement in biological processes such as epidermis development and keratinocyte differentiation, and pathways like valine, leucine, and isoleucine degradation. Immune infiltration analysis showed significant downregulation of 14 immune cell types in the resistant group, with notable negative correlations between hub genes and specific immune cells. We constructed a diagnostic model with an area under the curve (AUC) greater than 0.9,,validated externally, demonstrating robust diagnostic performance. Interaction networks, including mRNA-TF, RBP-mRNA, and lncRNA-miRNA-mRNA, provided insights into the complex regulatory mechanisms of resistance.