bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural and functional alterations in hematological parameters among individuals at clinically high risk for acute lymphocytic leukemia
Authors: Afzal Mohd , Sharma Abhishek , Sah Ashok Kumar , Chahal Aksh 
Published: September 2024

Abstract:
Acute lymphocytic leukemia (ALL) is a diverse category of hematological malignancies defined by the clonal proliferation of immature lymphoid cells. While advances in diagnostic procedures and treatment modalities have improved results for many patients, a group of them exhibit clinical characteristics that indicate a high risk of disease progression and unfavorable consequences. Understanding the underlying molecular processes and developing accurate prognostic indicators in this high-risk group is critical for personalized treatment approaches and better patient outcomes. Hematological markers, immunophenotyping profiles, and chromosomal defects in people who were clinically high risk (CHR) for ALL are discussed in this review. Alterations in hematological markers, such as elevated white blood cell counts, decreased hemoglobin levels, and thrombocytopenia, are indicative of the aggressive nature of high-risk ALL. Immunophenotyping investigations revealed abnormal expression patterns of lineage-specific markers, indicating clonal proliferation and differentiation arrest. Furthermore, cytogenetic examination revealed frequent chromosomal defects, such as the Philadelphia chromosome and hyperdiploidy, which have been linked to a poor prognosis in ALL patients. The combination of hematological, immunophenotypic, and cytogenetic data gives a thorough knowledge of disease biology and assists in risk assessment for patients with CHR for ALL. The present review elucidates the intricate interaction of hematological, immunophenotypic, and cytogenetic abnormalities in persons at clinically high risk for ALL, emphasizing the importance of integrated diagnostic techniques to enhance patient outcomes and optimize treatment strategies.
Unilateral Recurrent Laryngeal Nerve Palsy with H1N1 Pneumonia – An Uncommon Presentation
Authors: Ranga Sushmita , Kumar Rahul , Batra Tanvi , Kakar Atul 
Published: September 2024

Abstract
H1N1 pneumonia-associated vocal cord palsy is a rare condition. This case report highlights about a 70-year-old male, with multiple comorbidities, who presented with cough and shortness of breath. During hospitalization, he developed hoarseness of voice. On laryngoscopy, the right vocal cord was paralyzed. He was diagnosed with H1N1-associated right recurrent laryngeal nerve (RLN) paralysis. He received steroid therapy for the same and responded well. His voice completely recovered after 2 months. Viral infections are less common but important causes of recurrent nerve palsy. Other than influenza, severe acute respiratory syndrome coronavirus 2, Epstein–Barr Virus, cytomegalovirus, and varicella-zoster virus can also affect RLN. A detailed history, general examination, and appropriate investigations are important to exclude other possible etiological factors. Unilateral RLN palsy associated with viral infections is usually reversible and responds well to steroids as well as speech therapy.
Traumatic Spigelian Hernia Due to Blunt Trauma in Elderly with Delayed Presentation – An Unusual Case Report
Authors: Kavitha Agrawal , Kundal Ajay , Saxena Puja , Gill Ravneet Kaur 
Published: September 2024

Abstract
Traumatic abdominal wall hernia (TAWH) is an unexpected clinical diagnosis. Amongst them, traumatic Spigelian hernia is the rarest form where contrast-enhanced computed tomography (CECT) abdomen is the imaging of choice. Treatment options include exploratory open or minimally invasive surgery with or without the use of prosthetic mesh. Non-operative treatment can be an option in selected patients. Almost all the cases reported in the past show preponderance of TAWH in young male patients with immediate manifestation requiring emergency laparotomy. We present our experience of successfully managing a 65-year-old woman who had delayed presentation after blunt trauma abdomen who was diagnosed with Spigelian hernia on CECT abdomen and underwent an elective mesh hernioplasty. The patient was followed up till 3 months post-operatively with an uneventful course. Traumatic Spigelian hernia is an unexpected clinical condition and is mostly missed during the initial presentation. It should be suspected in cases having abdominal protrusion following blunt trauma. Treatment is tailored according to the patient’s mode of injury, presentation and associated comorbidities. Presentation in elderly females with delayed symptoms days after the trauma is unreported yet.
The association between postdiagnosis smoking cessation and survival in advanced non-small cell lung cancer patients in Southern Taiwan: A retrospective cohort study
Authors: Shen Chi-Hsiang , Yang Li-Yu 
Published: September 2024

ABSTRACT

Objectives:
Smoking is a major lung cancer risk factor. Studies show that smoking after lung cancer diagnosis is associated with an increased risk of developing other cancers and shorter survival. The purpose of this study was to examine the association between postdiagnosis smoking cessation and survival in patients with advanced non-small cell lung cancer (NSCLC).

Materials and Methods:
A retrospective cohort study was conducted. Data were collected between January 2014 and December 2019 in three hospitals in Southern Taiwan. Patient data were collected from the hospitals’ databases, and the correlation between smoking status and patient survival was analyzed using Kaplan–Meier curves and Cox proportional hazards regression modeling.

Results:
A total of 681 patients with advanced NSCLC were included in this study. The numbers (percentage) of ex-smokers and current smokers were 334 (49%) and 347 (51%), respectively. More than half of the patients in this study continued to smoke postdiagnosis advanced NSCLC. Furthermore, ex-smokers had lower mortality risk, even though this was not statistically significant (P = 0.212). The results of this study suggest that older than 65 years, men, Eastern Cooperative Oncology Group performance score of 3 and higher, history of chronic disease, receive chemotherapy, and targeted therapy are correlated with and have predictive effects on advanced NSCLC survival.

Conclusion:
There is no significant difference between postdiagnosis smoking cessation and survival in patients with advanced NSCLC. The reason for this finding may be due to lower survival rates after diagnosis with advanced NSCLC, and the benefits of smoking cessation cannot be seen immediately.
OPPORTUNITIES FOR INTEGRATION OF DIGITAL BUSINESS MODELS IN INTERGENERATIONAL BUSINESSES
Authors: Pavlov Daniel , Todorova Ana 
Published: September 2024

In today‘s hyper-­digitalised world, continuity and collaboration between digital and traditional business models becomes a necessary and even mandatory condition for achieving competitiveness and success. This key emphasis also applies to intergenerational business initiatives, which have the potential to bring together the knowledge, experience and creativity of different generations in a win-win way for all stakeholders. The main objective of the present research is to analyse the benefits of integrating digital business models in the context of intergenerational entrepreneurial initiatives. In order to achieve the goal formulated in this way, fundamental definitions and characteristics of the concept of „digital business model“ have been derived, supported by the existing theoretical knowledge and practical experience of the authors of the report. In addition, basic types of business models developed primarily in a digital environment have been identified, and current examples from the field of digital entrepreneurship have been synthesised. The scope of the research includes the results of a survey conducted in 2023 at the University of Ruse „Angel Kanchev“ (Bulgaria), covering 581 students. This aspect of the study aims to illuminate students‘ readiness to engage in intergenerational entrepreneurial initiatives. The discussion is enriched with reduced potential opportunities for the capacity of digital business models to improve the performance of individual family business ventures innovatively. In this way, by combining traditional with digital, it is possible to construct a solid and integrated intergenerational entrepreneurial chain capable of preserving and building on existing values and experiences in a positive way.
DIRECTIONS AND MECHANISM FOR STRATEGIC DEVELOPMENT OF GRAIN PRODUCTION IN NIZHNY NOVGOROD REGION
Authors: Generalov Ivan G. 
Published: September 2024

The strategic development of grain production is a very relevant area, since in order to remain competitive in the long term, it must be transformed into a high-tech branch of the national economy. The purpose of the study: justification of directions and development of a mechanism for strategic development of grain production in the Nizhny Novgorod region. Within the framework of this goal, a critical analysis of studies on this problem was carried out. Based on the use of methodological tools such as SWOT analysis and the BSC method, the directions of strategic development of grain production in the Lower Rod region were scientifically substantiated, and thanks to the empirical modeling method, the Ministry of Management of Strategic Development of Grain Production in this region was developed. As a result, the author highlighted and specified the following areas of strategic development of grain production: a breakthrough strategy, strategies aimed at qualitative renewal of production technologies in conditions of production instability and a survival strategy. The directions were drawn up in the form of a map of the strategic development of grain production in the Nizhny Novgorod region. The mechanism proposed by the author to manage the strategic development of grain production in the region includes such subsystems as goal setting, strategy, control and implementation of the developed areas of strategic development. As a result, the implementation of the proposed directions on the basis of the mechanism for strategic development of grain production will contribute to its transformation into a high-tech industry.
ASSESSING THE RESULTS OF INNOVATIVE ACTIVITIES OF ENTERPRISES IN THE INTERESTS OF ACHIEVING TECHNOLOGICAL SOVEREIGNTY OF THE RUSSIAN ECONOMY
Authors: Gurlev Vladimir G. , Khomiakova Tatiana S. , Sliva Svetlana V. 
Published: September 2024

In the context of the need to reduce technological dependence and structural changes in the economy, it is important to solve the problems of ensuring technological sovereignty by enhancing the innovative activity of enterprises and the growth of innovative activity in the context of industries and regions. The expediency of identifying innovative activities is justified by the opportunity to evaluate the activity of the enterprise as a result. In this work, a complex of factors has been identified and the functional dependencies of their influence on the innovative activities of enterprises have been determined. Groups of indicators characterizing the innovative activities of enterprises have been developed, defined, formalized and classified. A methodology and methods for assessing the influence of factors on the results of an enterprise’s innovative activities have been developed. The assessment of the results of an enterprise’s innovative activity in the presented work is associated with the grouping of indicators of innovative activity based on the obtained mathematical generalized indicator. An assessment is made of the contribution of the enterprise’s innovative activities to ensuring the technological sovereignty of the national economy.
FORMATION OF HYBRID ORGANIC AGRI-FOOD SYSTEMS BASED ON CONSORTIUMS
Authors: Galkin Denis G. 
Published: September 2024

The article discusses the hypothesis of combining small and large producers of organic food into associations and consortiums, where each business entity will receive certain advantages. In the course of the study, the author took into account the features of the types and experience of state support for existing organic agro-food systems, the main beneficiaries of the progressive development of these systems. The study is based on the synthesis of types of modern, traditional and mixed organic agro-food systems, which made it possible to identify the possibility of forming a new type of system — ​hybrid organic agri-food systems. The results of the study showed that cooperatives and associations can become the most acceptable forms of hybrid systems at the initial stage of their formation. The addition of an agro-industrial holding to the system will allow the formation of consortiums, which are proposed to be considered as the main form of hybrid organic agri-food systems and a mechanism for scaling them up to create export sectors based on small and medium-­sized businesses. In order to identify the interests of the main beneficiaries of the consortiums, the stakeholder analysis method was used, which shows that it is the state that is the main recipient of the positive effects from the development of hybrid organic agro-food systems. These effects include: preservation of natural capital, reduction of unemployment in rural areas, slowing down the rate of rural migration, involvement in the circulation of unused land, strengthening the health of the nation and increasing farmers’ incomes. At the same time, a necessary condition for the formation and scaling of organic consortiums are state support measures that can be aimed at stimulating the interaction of business entities and protecting the interests of small farmers.
A STUDY OF THE RELATIONSHIP BETWEEN DOMESTIC AND WORLD WHEAT PRICES IN THE EU AND IN RUSSIA
Authors: Karashchuk Oksana S. , Boldiasov Alexey I. 
Published: September 2024

The article is devoted to the study of the influence of the dynamics of world wheat prices on the change in domestic prices for this commodity in various countries in conditions of significant volumes of export-­import operations. Theoretical analysis has shown that, in accordance with the law of a single price, in conditions of perfect competition, domestic prices should change in proportion to fluctuations in world prices, whereas in conditions of imperfect competition, domestic prices will change to a greater extent than world prices. The analysis of correlations allowed us to determine that the wheat markets of the EU countries are characterized by a relationship between domestic and world prices with great statistical significance, for some countries this relationship was determined taking into account the time lag of world prices. The relationship between domestic and global wheat prices has not manifested itself, which is most likely a consequence of state interference in market processes, since the necessary prerequisite for the implementation of the single price law is the absence of active state regulation. Further research allowed us to establish that in the long term, domestic wheat prices in the EU countries change almost in proportion to the volatility of world prices. In the short term, the relationships turned out to be different for individual countries studied and independent of the share of wheat exports and imports in the country’s production and the average share of the country in world wheat trade.
KEY ASPECTS OF ECONOMIC SECURITY OF THE RUSSIAN REGION (CASE OF LIPETSK REGION)
Authors: Rumyantseva Yulia V. , Markova Ekaterina S. , Mitrofanova Olga N. 
Published: September 2024

The article is devoted to the issues of economic security of the Russian region using the example of the Lipetsk region. The study updates the role of regional economic security based on an in-depth analysis of the theoretical concepts of scientists over the past 20 years. Based on the works of the Russian economist S. Y. Glazyev, in which he uses his author’s, integral approaches to indicators of reproduction of human and economic potential, researchers assess the state of economic security in the Lipetsk region. The authors conclude that the main trend at the moment is the “forced” growth of production, not provided with sufficient labor resources for the future, accompanied by low socio-­economic indicators of reproduction. Having sufficiently advantageous geographical, climatic and natural resources, the Lipetsk region does not have a high development potential at this point in time due to the low level of self-awareness of the population. The level of crime, alcoholism or fertility is often not related to the economic standard of living of the population, but rather depends on the level of development of the individual and society. The lack of capital investments in fixed assets for the future shows the lack of strategic goals of producers and the desire to obtain short-term benefits. The authors see the development of patriotic, spiritual and moral education as one of the directions for improving the indicators of reproduction of human and economic potential in the region.
POSITIONING OF RUSSIAN REGIONS IN LONG-TERM AND MEDIUM-TERM ECONOMIC GROWTH RATINGS
Authors: Benz Daria S. 
Published: September 2024

In the article the author creates ratings of Russian regions according to criteria — ​long-term and medium-term real economic growth. An indicator of economic growth is the index of the physical volume of gross regional product. By the long-term period we mean the period from 1997 to 2021, by the medium-term period — ​the period from 2016 to 2021. The purpose of the study is to rank the regions according to these periods. Objectives of the study are following: to conduct a comparative analysis of the results of building two ratings; to show the spatial location of regions from the standpoint of long-term economic growth; to show the specialization of the leading regions. Specific research methods are the ranking method, comparative and correlation analyses, and the graphical illustration method. The leaders of both long-term and medium-term economic growth are three regions. These are St. Petersburg, the Moscow region and the Republic of Adygea. The absolute outsider according to both ratings is the Komi Republic. The industry specificity of the leading regions was obtained: all regions are characterized by specialization in manufacturing. Regions leading long-term and medium-term growth also specialize in non-production activities — ​wholesale and retail trade, real estate operations. The leading regions of medium-term growth specialize both in the extractive industry and in the fields of transport and communications.
Strategic Framework for Human-Centric AI Governance: Navigating Ethical, Educational, and Societal Challenges
Authors: Chris Gilbert  , Mercy Abiola Gilbert  
Published: September 2024

Abstract: Humanity is at the precipice of a profound transformation, propelled by the rapid evolution of artificial intelligence (AI). Once confined to the realm of science fiction, AI now permeates every aspect of daily life, promising significant changes to our social, economic, and personal spheres. As AI systems continue to advance and surpass human capabilities in various domains, they present unparalleled opportunities as well as formidable challenges. This composition explores the dualistic nature of AI, acknowledging its capacity to either augment or disrupt our existence. By examining AI's current state, potential risks, and ethical considerations, we emphasize the pressing need for a comprehensive framework to govern its development and integration. We propose a multifaceted framework built on five fundamental principles: human centered design, transparency and interpretability, accountability and governance, education and upskilling, and inclusive and equitable access. These principles are designed to ensure that AI systems enhance human capabilities, promote transparency, uphold ethical standards, and provide equitable access to the benefits of technology. Through in-depth case studies, we illustrate the practical application of this framework, showcasing AI's impact across various industries while emphasizing the importance of addressing ethical and societal challenges. This composition calls for a collective effort among governments, corporations, and individuals to navigate the rapid expansion of AI responsibly, fostering a future where AI and humanity coexist harmoniously. The ultimate goal is to harness the potential of AI to revitalize society, ensuring that technological progress elevates human dignity and collective well-being instead of rendering us obsolete.
Parameterizations for global thundercloud corona discharge distributions
Authors: Soler Sergio , Gordillo-Vázquez Francisco J. , Pérez-Invernón Francisco J. , Jöckel Patrick , Neubert Torsten , Chanrion Olivier , Reglero Victor , Østgaard Nikolai 
Published: September 2024

Abstract. Four parameterizations, distinguishing between land and ocean, have been developed to simulate global distributions of thundercloud streamer corona discharges (also known as Blue LUminous Events or BLUEs) mainly producing bluish optical emissions associated with the second positive system of N2 accompanied by no (or hardly detectable) 777.4 nm light emission. BLUEs occur globally about 12 times less frequently (Soler et al., 2022) than lightning flashes. The four schemes are based on non-linear functions of the cloud-top height (CTH), the product of the convective available potential energy (CAPE) and total precipitation (TP), the product of CAPE and specific cloud liquid water content (CLWC), and the product of CAPE and specific cloud snow water content (CSWC). Considering that thunderstorms occur on hourly timescales, these parameterizations have been tested using hourly ERA5 data (except for CTH, not available in ERA5) for the meteorological variables considered, finding that the proposed BLUE schemes work fine and are consistent with observations by the Atmosphere–Space Interactions Monitor (ASIM). Moreover, the parameterizations have been implemented in a global chemistry–climate model that generates annual and seasonal global distributions for present-day and end of 21st century climate scenarios. Present-day predictions are in reasonable agreement with recent observations by the ASIM. Predictions for the end of the 21st century suggest BLUE occurrence rates that range between 13 % higher (∼ 3 % K−1) and 52 % higher (∼ 13 % K−1) than present-day average occurrences of BLUEs.