bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disseminated Emmonsia pasteuriana infection in India: a case report and a review
Authors: Malik Rupali , Capoor Malini R. , Vanidassane Ilavarasi , Gogna Arun , Singh Avninder , Sen Biswajit , Rudramurthy Shivaprakash M. , Honnavar Prasanna , Gupta Sunita , Chakrabarti Arunaloke 
Published: December 2015

SummaryWe report here the first case of disseminated Emmonsia pasteuriana infection in a patient with AIDS in India. The patient presented with weight loss, dyspnoea, left‐sided chest pain and multiple non‐tender skin lesions over face and body for 3 months. Disseminated emmonsiosis was diagnosed on microscopic examination and fungal culture of skin biopsy and needle aspirate of lung consolidation. It was confirmed by sequencing internal transcribed spacer region of rDNA, beta tubulin, actin, and intein PRP8. The patient responded to amphotericin B and itraconazole therapy.
SET DOMAIN GROUP 708, a histone H3 lysine 36‐specific methyltransferase, controls flowering time in rice (Oryza sativa)
Authors: Liu Bing , Wei Gang , Shi Jinlei , Jin Jing , Shen Ting , Ni Ting , Shen Wen‐Hui , Yu Yu , Dong Aiwu 
Published: December 2015

Summary

As a key epigenetic modification, the methylation of histone H3 lysine 36 (H3K36) modulates chromatin structure and is involved in diverse biological processes.

To better understand the language of H3K36 methylation in rice (Oryza sativa), we chose potential histone methylation enzymes for functional exploration. In particular, we characterized rice SET DOMAIN GROUP 708 (SDG708) as an H3K36‐specific methyltransferase possessing the ability to deposit up to three methyl groups on H3K36.

Compared with the wild‐type, SDG708‐knockdown rice mutants displayed a late‐flowering phenotype under both long‐day and short‐day conditions because of the down‐regulation of the key flowering regulatory genes Heading date 3a (Hd3a), RICE FLOWERING LOCUS T1 (RFT1), and Early heading date 1 (Ehd1). Chromatin immunoprecipitation experiments indicated that H3K36me1, H3K36me2, and H3K36me3 levels were reduced at these loci in SDG708‐deficient plants. More importantly, SDG708 was able to directly target and effect H3K36 methylation on specific flowering genes. In fact, knockdown of SDG708 led to misexpression of a set of functional genes and a genome‐wide decrease in H3K36me1/2/3 levels during the early growth stages of rice.

SDG708 is a methyltransferase that catalyses genome‐wide deposition of all three methyl groups on H3K36 and is involved in many biological processes in addition to flowering promotion.
Structural polymorphisms and distinct genomic composition suggest recurrent origin and ongoing evolution of B chromosomes in the Prospero autumnale complex (Hyacinthaceae)
Authors: Jang Tae‐Soo , Parker John S. , Weiss‐Schneeweiss Hanna 
Published: December 2015

Summary

Supernumerary B chromosomes (Bs) are genomic parasitic components, originating from the A complement via chromosomal rearrangements, which follow their own evolutionary trajectories. They often contain repetitive DNAs, some shared with regular chromosomes and some newly evolved. Genomic composition, origin and evolution of Bs have been analysed in the chromosomally variable Prospero autumnale complex.

Two rDNAs and a satellite DNA (PaB6) from regular chromosomes were mapped to Bs of 26 plants from three diploid cytotypes, their hybrids and polyploid derivatives. In homoploid diploid hybrids, genomic in situ hybridization (GISH) allowed B painting with the parental DNAs.

Bs were structurally variable and highly enriched in 5S rDNA and satDNA PaB6, and rarely in 35S rDNA. Eleven combinations of rDNA and PaB6 localization were observed. The quantities of PaB6 in Bs and regular chromosomes were not correlated, suggesting amplification mechanisms other than recombination. PaB6 and 5S rDNA amounts increased with increasing ploidy level. GISH revealed two independent origins of Bs.

The structural variation, repeat content, repeat‐type fluctuations and differing genomic affinities of Bs in different cytotypes suggest that they represent young proto‐B chromosomes. Bs in P. autumnale probably form recurrently as by‐products of the extensive genome restructuring within this chromosomally variable species complex.
The association between emotions and eating behaviour in an obese population with binge eating disorder
Authors: Nicholls W. , Devonport T. J. , Blake M. 
Published: December 2015

SummaryThere is utility in understanding the antecedents of binge eating (BE), with a view to explaining poorer weight loss treatment responses in this subgroup. A systematic review was completed according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines with the aim of exploring associations between emotions and eating behaviour in a population affected by obesity and binge eating disorder (BED). A comprehensive literature search of four electronic databases (2004–2014) yielded 15 studies for inclusion. Included studies performed poorly on data quality analysis with respect to controlling for confounding variables, and sample size. Included papers largely focused on negative emotions as antecedents of BE; depression was consistently associated with a BED‐obese classification and BE. Negative mood, sadness, tension and instability of emotions were found to be antecedents of BE in an adult BED‐obese sample. However, findings were mixed regarding the role of stress, anger and positive emotions within the BED‐obese population. Recommendations are presented for the identification of BED, and ecologically valid experimental designs that further understanding of the complex and varied emotions that associate with BE. The implications of these and other limitations for both researchers and practitioners are discussed. The paper concludes with recommendations for future research alongside suggestions for practitioners. © 2015 World Obesity
Linear Morphea Mimicking Lichen Striatus in Its Early Presentation
Authors: Muñoz Garza Fania Zamantta , Manubens Mercadè Elena , Roè Crespo Esther , Puig Sanz Lluis , Baselga Torres Eulàlia 
Published: December 2015

AbstractLinear morphea and lichen striatus are distinct conditions that have been linked in only one previous case report. We describe two patients with facial lichen striatus preceding linear morphea at the same site. A possible pathogenic relationship is discussed.
Neonatal Blue Light Phototherapy and Melanocytic Nevus Count in Children: A Systematic Review and Meta‐Analysis of Observational Studies
Authors: Lai Yi Chun , Yew Yik Weng 
Published: December 2015

AbstractBackgroundNeonatal blue light phototherapy (NBLP) is an established method of managing neonatal hyperbilirubinemia. Approximately 5% of newborns are exposed to NBLP. Evidence of whether NBLP predisposes to the development of melanocytic nevi later in life has been conflicting.ObjectivesThe goal of the current study was to conduct a systematic review and meta‐analysis to quantitatively assess the effect of NBLP on melanocytic nevus count.MethodsWe searched for observational studies in Medline, EMBASE, and the Cochrane Central Register from their inception to April 15, 2015. Meta‐analysis of Observational Studies in Epidemiology guidelines were followed. DerSimonian and Laird random‐effects models were used to calculate the weighted mean difference (WMD). Publication bias was assessed using a funnel plot and the Egger's test.ResultsFive studies with a total of 2,921 subjects were included, of whom 642 underwent NBLP. With random‐effects modeling, those who had previous NBLP did not have a significantly higher mean number of melanocytic nevi (WMD = 0.32 [95% confidence interval −0.67, 1.31], p = 0.53). Visual inspection of the funnel plot suggested potential publication bias, although the Egger's test (p = 0.09) indicated no small‐study effect.ConclusionThere was no evidence that prior NBLP exposure significantly increased the number of melanocytic nevi. Available evidence has not revealed any cause for major concern for NBLP. Other risk factors such as exposure to sunlight, childhood history of sunburn, and fair skin complexion might play a greater role in the development of melanocytic nevi in childhood.
Pragmatics and Semantics and Husserl and Derrida
Authors: Kates Joshua 
Published: December 2015

AbstractThis piece undertakes to sketch the contemporary approaches toward meaning known as pragmatics and semantics. Today, this pairing is associated with a controversy or question that concerns the proposition (the portion of what is said or meant or expressed by sentences, capable of being true or false). Yet, while the pragmatics/semantics debate attests to the proposition's precise status being in doubt, the underlying belief remains that the work of the proposition or something like it – e.g., utterances, a portion of which function propositionally – eventually can be established. Jacques Derrida in his writings on Husserl questions even this assumption. He argues that there is an internal limit to propositionality (without abandoning this notion entirely), thanks to a writing (écriture) that ultimately exceeds it. Moreover, Derrida focuses on themes (in particular, the index and what Husserl called essentially occasional expressions) that are central for the discussions of semantics and pragmatics, while a good deal of common ground exists between Derrida's interlocutor, Husserl, and the analytic tradition. Accordingly, after here reviewing pragmatics and semantics, and some of the complexity of their relation, I turn to Husserl and to Derrida ultimately for a perspective that calls into doubt these projects as such.
Experimental Philosophy of Aesthetics
Authors: Cova Florian , Garcia Amanda , Liao Shen‐yi 
Published: December 2015

AbstractIn the past decade, experimental philosophy – the attempt at making progress on philosophical problems using empirical methods – has thrived in a wide range of domains. However, only in recent years has aesthetics succeeded in drawing the attention of experimental philosophers. The present paper constitutes the first survey of these works and of the nascent field of ‘experimental philosophy of aesthetics’. We present both recent experimental works by philosophers on topics such as the ontology of aesthetics, aesthetic epistemology, aesthetic concepts, and imagination, as well as research from other disciplines that not only are relevant to philosophy of aesthetics but also open new avenues of research for experimental philosophy of aesthetics. Overall, we conclude that the birth of an experimental philosophy of aesthetics is good news not only for aesthetics but also for experimental philosophy itself, as it contributes to broaden the scope of experimental philosophy.
Revisiting Foucault's ‘Normative Confusions’: Surveying the Debate Since the Collège de France Lectures
Authors: Mayes Christopher R. 
Published: December 2015

AbstractAt once historical and philosophical, Michel Foucault used his genealogical method to expose the contingent conditions constituting the institutions, sciences and practices of the present. His analyses of the asylum, clinic, prison and sexuality revealed the historical, political and epistemological forces that make up certain types of subjects, sciences and sites of control. Although noting the originality of his work, a number of early critics questioned the normative framework of Foucault's method. Nancy Fraser argued that Foucault's genealogical method was ‘normatively confused’ as it implied political critique yet claimed to be value‐neutral. Jürgen Habermas and Charles Taylor also questioned the normative basis of Foucault's appeals to critique, arguing it was self‐refuting as Foucault left no room for the subject to escape power. Although a debate among these scholars was planned for the mid‐1980s, Foucault's death in 1984 meant this could not occur. A number of edited volumes sought to fabricate a debate, with defenders of Foucault excavating his published monographs to construct responses to his critics. While the monographs remain the central texts of Foucault's oeuvre, over the past decade his Collège de France lectures have been published and translated into English. This article offers a schematic survey of the influence of the Collège de France lectures in recasting different points in the debates over normativity, critique and resistance.
Gp91phox‐derived Reactive Oxygen Species/Urocortin 2/Corticotropin‐releasing Hormone Receptor Type 2 Play an Important Role in Long‐term Ultraviolet A Eye Irradiation‐induced Photoaging
Authors: Hiramoto Keiichi , Yamate Yurika 
Published: December 2015

AbstractPhotoaging is induced by long‐term ultraviolet A (UVA) eye irradiation. However, the mechanism of skin damage due to UVA eye irradiation is still not well understood. In this study, we used C57BL/6j and gp91phox knockout (gp91phox−/−) mice for the long‐term effects of UVA irradiation. The eye or dorsal skin of the mice was locally exposed to UVA for 12 months. The reactive oxygen species (ROS), gp91phox, corticotropin‐releasing hormone (CRH), urocortin 2, and CRH receptor (CRHR) type 1 and type 2 levels in the brain and mast cell tryptase and histamine levels in the dorsal skin all increased after UVA irradiation. The levels of CRH, urocortin 2, CRHR type 1 and type 2 in the brain also increased more after UVA eye irradiation than after UVA skin irradiation. Moreover, photoaging of the UVA eye irradiation mice was not induced following the administration of a ROS inhibitor in the brain. In addition, in gp91phox−/− mice, photoaging by UVA eye irradiation was not induced. These results indicate that long‐term UVA eye irradiation led to increased gp91phox‐derived ROS in the brain and the increased expression of urocortin 2 and CRHR type 2, resulting in photoaging; however, further studies are needed to confirm these findings.
Body Mass Index, Waist Circumference, and the Clustering of Cardiometabolic Risk Factors in Early Childhood
Authors: Anderson Laura N. , Lebovic Gerald , Hamilton Jill , Hanley Anthony J. , McCrindle Brian W. , Maguire Jonathon L. , Parkin Patricia C. , Birken Catherine S. ,   TARGet Kids Collaboration
Published: December 2015

AbstractBackgroundObesity has its origins in early childhood; however, there is limited evidence of the association between anthropometric indicators and cardiometabolic risk factors in young children. Our aim was to evaluate the associations between body mass index (BMI) and waist circumference (WC) in relation to cardiometabolic risk factors and to explore the clustering of these factors.MethodsA cross‐sectional study was conducted in children aged 1–5 years through TARGet Kids! (n = 2917). Logistic regression was used to evaluate associations between BMI and WC z‐scores and individual traditional and possible non‐traditional cardiometabolic risk factors. The underlying clustering of these measures was evaluated using principal components analysis (PCA).ResultsChild obesity (BMI z‐score >2) was associated with high (>90th percentile) leptin [odds ratio (OR) 8.15, 95% confidence interval (CI) 4.56, 14.58] and insulin (OR = 1.76; 95% CI 1.05, 2.94). WC z‐score >1 was associated with high insulin (OR 1.59, 95% CI 1.11, 2.28), leptin (OR 5.48, 95% CI 3.48, 8.63) and 25‐hydroxyvitamin D < 75 nmol/L (OR 1.39, 95% CI 1.08, 1.79). BMI and WC were not associated with other traditional cardiometabolic risk factors, including non‐High Density Lipoprotein (HDL) cholesterol, and glucose. Among children 3–5 years (n = 1035) the PCA of traditional risk factors identified three components: adiposity/blood pressure, metabolic, and lipids. The inclusion of non‐traditional risk factors identified four additional components but contributed minimally to the total variation explained.ConclusionsAnthropometric indicators are associated with selected cardiometabolic risk factors in early childhood, although the clustering of risk factors suggests that adiposity is only one distinct component of cardiometabolic risk. The measurement of other risk factors beyond BMI and WC may be important in defining cardiometabolic risk in early childhood.
Changes in c‐erbB‐2 Immunoexpression in Feline Endometrial Adenocarcinomas
Authors: Saraiva AL , Payan‐Carreira R , Gärtner F , Faria F , Lourenço LM , Pires MA 
Published: December 2015

ContentsHuman epidermal growth factor receptor type 2 (c‐erbB‐2), an oncoprotein with potential prognostic marker and therapeutic use, is overexpressed in several human and animal tumours. But information regarding this molecule in feline tumours is scarce. This study aimed to assess the changes in the immunohistochemical expression of c‐erbB‐2 in feline endometrial adenocarcinomas (FEA) compared to normal endometrium. An immunohistochemistry assay using a specific antibody against c‐erbB‐2 was performed in FEA samples (n = 34) and in normal endometrium in the follicular (FS; n = 12) and luteal (LS; n = 11) stages. In FEA, the c‐erbB‐2 immunoexpression was assessed in neoplastic epithelial cells whilst in normal endometria it was individually evaluated in the surface and the superficial and deep glandular epithelia (SE, SGE and DGE, respectively). In FS and in LS, all the epithelia were positive for c‐erbB‐2; positivity was higher in the SE and the SGE than in DGE. Twenty of the 34 FEA samples (58.8%) were positive for c‐erbB‐2 immunolabelling. Nevertheless, its expression was higher in all the epithelia in the FS compared to FEA (p ≤ 0.0001) or the LS (p = 0.016). The results presented herein suggest that c‐erbB‐2 molecule is differently expressed in the feline endometrium through the oestrous cycle and though it may also be involved in feline endometrial carcinogenesis, a question remains unanswered on the importance of additional pathways of epithelial proliferation in the neoplastic changes in feline endometrium.
Association of sedentary time and physical activity with pain, fatigue, and impact of fibromyalgia: the al‐Ándalus study
Authors: Segura‐Jiménez V. , Borges‐Cosic M. , Soriano‐Maldonado A. , Estévez‐López F. , Álvarez‐Gallardo I. C. , Herrador‐Colmenero M. , Delgado‐Fernández M. , Ruiz J. R. 
Published: December 2015

We examined the association of objectively measured sedentary time (ST) and physical activity (PA) levels with pain, fatigue, and the impact of the disease in women with fibromyalgia. Four hundred and nineteen (mean age ± SD = 51.7 ± 7.6 years old) women with fibromyalgia participated. ST and PA levels (light, moderate, and moderate‐to‐vigorous [MVPA]) were measured with triaxial accelerometry. We assessed experimental pain with algometry and clinical pain, fatigue, and impact of fibromyalgia with a number of questionnaires. The association of ST and light PA with most of the pain‐ and fatigue‐related outcomes and impact of fibromyalgia (all, P ≤ 0.019) was independent of moderate and vigorous PA. Furthermore, the association of vigorous PA with general and physical fatigue was independent of ST and light and moderate PA (all, P < 0.001). In conclusion, lower levels of ST or higher levels of light PA are associated with lower pain, fatigue, and the overall impact of the disease independent of moderate and vigorous PA in women with fibromyalgia. Interestingly, higher vigorous PA is independently associated with lower general and physical fatigue. These results are significant for future ST and PA intervention studies in this population.
Contingent Self‐worth in Chinese Adolescents and Young Adults: Relations with Global Self‐Esteem and Depressive Symptoms
Authors: Chen‐Bouck Li , Patterson Meagan M. 
Published: December 2015

AbstractContingent self‐worth (CSW) is the extent to which an individual's sense of self‐worth is dependent on performance in a particular domain. CSW has been linked to poorer psychological health (e.g., lower global self‐esteem, greater depression and anxiety). However, the majority of work on CSW has been conducted with US college students. Far less is known about the influence of CSW for younger individuals or for non‐Western populations. This study examined relations between CSW domains and two indicators of well‐being (depressive symptoms and global self‐esteem) with Chinese adolescents (ages 13–16) and young adults (ages 19‐22). Results indicated that CSW in the domains of academic performance and others’ approval were positively related to depressive symptoms, whereas CSW in the domain of family support was negatively related to depressive symptoms. Others’ approval CSW was negatively related to self‐esteem for both adolescents and young adults, whereas CSW in the domains of academic performance and family support were related to self‐esteem for adolescents but not young adults. This study indicates that CSW is a meaningful and predictive construct for Chinese youth, and that cultural, environmental, and developmental factors may impact the relations between CSW and psychological health.
The effects of omeprazole therapy on bacterial colonization of the pharynx in healthy dogs
Authors: Sullivan Lauren A. , Wakayama Justin , Boscan Pedro L. , Hyatt Doreene R. , Twedt David C. , Lappin Michael R. , Dargatz David A. 
Published: December 2015

AbstractObjectiveTo identify the relative abundance of commensal pharyngeal flora in healthy dogs and determine if abundance of pharyngeal flora is altered during omeprazole administration.AnimalsEight adult Beagles.ProceduresA total of 3 baseline pharyngeal swabs, collected 48 hours apart, were obtained from each dog. Omeprazole (1 mg/kg PO q 24 h) was administered for a total of 12 days. During omeprazole administration, pharyngeal swabs were obtained on Days 8, 10, and 12. All swabs were submitted for semiquantitative aerobic and anaerobic culture. Growth of bacterial isolates, as well as genus of isolates, was compared between the pretreatment (n = 24) and treatment (n = 24) swabs.ResultsA greater abundance of several bacterial species was identified during the treatment period, including coagulase‐negative Staphylococcus (P < 0.01), Bacillus (P < 0.01), and Pasteurella (P = 0.05). The abundance of bacterial species in samples collected during the treatment period was unchanged for Escherichia coli (P = 0.16), Provotella (P = 0.40), hemolytic Streptococcus (P = 0.34), and nonhemolytic Streptococcus (P = 0.14).Conclusions and Clinical RelevanceThis small study indicates that shifts in canine pharyngeal flora may occur during omeprazole therapy. Further studies are warranted to determine the clinical significance of gastric acid suppressants on pharyngeal flora in dogs.