bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of pulmonary vein isolation using a surround flow catheter with contact force measurement capabilities: A multicenter registry
Authors: Stabile Giuseppe , Di Donna Paolo , Schillaci Vincenzo , Di Monaco Antonio , Iuliano Assunta , Caponi Domenico , Urraro Francesco , Solimene Francesco , Grimaldi Massimo , Scaglione Marco 
Published: April 2017

AbstractIntroductionPulmonary vein (PV) isolation is the cornerstone of catheter ablation in patients with atrial fibrillation (AF). Surround flow and contact force (CF) measurement capabilities might enhance procedure efficacy and safety. We report on the safety and midterm efficacy of a novel ablation catheter for PV isolation in patients with AF.Methods and resultsTwo hundred thirty‐three consecutive patients (57 ± 11 years, 76% males, 51% with structural heart disease), referred for paroxysmal (157) or persistent (76) AF, underwent PV isolation by a surround flow catheter with CF measurement capability in four centers. Ablation was guided by electroanatomic mapping allowing radiofrequency (RF) energy delivery in the antral region aiming at PV isolation.Mean overall procedure time was 100 ± 42 minutes with a mean fluoroscopy time of 6 ± 5 minutes. Mean ablation time was 31±15 minutes; 99% of the targeted veins were isolated. The mean CF value during ablation was 13 ± 4 g. Intraprocedural early (30 minutes) PV reconnection occurred in 12% PVs, and all PVs were effectively reisolated. One pericardial effusion and five groin hematomas were reported. During a mean follow‐up of 12 ± 6 months, 30 (12.9%) (10% paroxysmal AF vs. 18% persistent AF, P = 0.07) patients had an atrial arrhythmias recurrence.ConclusionsIn this multicenter registry, RF ablation using a new surround flow catheter, with CF sensor, resulted as feasible, achieving a high rate of isolated PVs. Procedural and fluoroscopy times and success rates were comparable with other techniques with a low complication rate.
New host record and molecular characterization of Dicauda atherinoidiHoffman & Walker (Bivalvulida: Myxobolidae): a parasite of the emerald shinerNotropis atherinoidesRafinesque, 1818 and mimic shinerNotropis vollucellusCope, 1865
Authors: Loch T P , Rosser T G , Baumgartner W A , Boontai T , Faisal M , Griffin M J 
Published: April 2017

AbstractUpdated morphological and histopathological descriptions forDicauda atherinoidi(Bivalvulida:Myxobolidae) and an expanded host range are supplemented with the first molecular data and phylogenetic analyses of the genus. Plasmodia were located on the head, ventrum/body and fins of infected emerald shinerNotropis atherinoidesRafinesque, 1818 and mimic shinerNotropis vollucellusCope, 1865, a new host species. Myxospores were spherical, ranging 9.3–11.4 μm (10.5 ± 0.4) in length, 9.0–11.0 μm (9.7 ± 0.4) in width and 6.6–7.0 μm (6.8 ± 0.2) thick in sutural view, and possessed 2‐3 caudal processes (5.3–68.3 μm, 31.1 ± 13.6) connected to the spore body at the sutural groove, all of which are consistent with the genusDicauda. In the absence of availableDicaudasequence data, the 18SrDNAsequences from Michigan isolates were most similar toMyxobolusspp. Phylogenetic analyses clustered these isolates with myxobolid species from cyprinid fish, suggesting these parasites may represent an underpopulated group of cyprinid‐infecting myxozoans. Histopathology revealed thin‐walled plasmodial pseudocysts in the dermis and associated connective tissue, where granulomatous inflammation and focal scale atrophy were also present. Further sampling/sequencing of myxobolids fromNotropisspp. should expand these underrepresented myxozoans and offer further insight into Myxobolidae host family tropisms.
Antiviral activity of exopolysaccharides from Arthrospira platensis against koi herpesvirus
Authors: Reichert M , Bergmann S M , Hwang J , Buchholz R , Lindenberger C 
Published: April 2017

AbstractAlthough koi herpesvirus (KHV) has a history of causing severe economic losses in common carp and koi farms, there are still no treatments available on the market. Thus, the aim of this study was to test exopolysaccharides (EPS) for its antiviral activity against KHV, by monitoring inhibition and cytotoxic effects in common carp brain cells. These substances can be easily extracted from extracellular algae supernatant and were identified as groups of sulphated polysaccharides. In order to reach this aim, Arthrospira platensis, which is well known for its antiviral activity of intra‐ and extracellular compounds towards mammalian herpesviruses, was investigated as standard organism and compared to commercial antiviral drug, ganciclovir, which inhibits the viral DNA polymerization. The antiviral activity of polysaccharides of A. platensis against KHV was confirmed in vitro using qualitative assessment of KHV life cycle genes, and it was found by RT‐PCR that EPS, applied at a concentration of >18 μg mL−1 and a multiplicity of infection (MOI) of 0.45 of KHV, suppressed the viral replication in common carp brain (CCB) cells even after 22 days post‐infection, entirely. Further, this study presents first data indicating an enormous potential using polysaccharides as an additive for aquacultures to lower or hinder the spread of the KHV and koi herpesvirus disease (KHVD) in future.
A Survey of Women's Awareness of and Reasons for Lack of Postfracture Osteoporotic Care
Authors: Boudreau Denise M. , Yu Onchee , Balasubramanian Akhila , Wirtz Heidi , Grauer Andreas , Crittenden Daria B. , Scholes Delia 
Published: April 2017

ObjectivesTo identify women's beliefs and other factors associated with lack of osteoporosis (OP) pharmacotherapy (OP‐RX) during the 6 months after a fragility fracture, including the woman's perspective on fracture risk, OP, and treatment.DesignCross‐sectional.SettingGroup Health Cooperative, a mixed‐model delivery system.ParticipantsFemale Group Health Cooperative enrollees aged 55 and older with an OP‐related fracture according to diagnostic and procedure codes from January 1, 2013, to March 30, 2014 (N = 985).MeasurementsOP‐RX and participant characteristics were ascertained from electronic health records including medications dispensed. A mailed survey was used to obtain data on health behaviors; OP‐related history; concern about, knowledge of, and perceived risk of future fracture; beliefs about OP‐RX; sources of information on OP; postfracture discussions with providers; and provider recommendations.ResultsThe response rate was 73%. Of 634 eligible respondents, 84% did not undergo OP‐RX during the 6 months after fracture. Fewer than 20% of women thought that OP caused their fracture, 52% did not think they were at risk of future fracture, and 75% did not think or know whether OP‐RX reduces risk of fracture. Knowledge about OP and the benefits of treatment was higher in the 16% of women who underwent OP‐RX after their fracture. Women reported low levels of engagement with their healthcare providers regarding OP and fracture risk management.ConclusionThese findings suggest low awareness about OP and its contribution to fracture risk, lack of understanding about the benefits of pharmacotherapy, and limited discussion about OP with primary care physicians. Information about individual's beliefs and knowledge gaps can help design targeted patient and provider education to improve treatment rates.
Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double‐blind, and placebo‐controlled study
Authors: Kim Do Un , Chung Hee Chul , Kim Changhee , Hwang Jae‐Kwan 
Published: April 2017

SummaryBackgroundPhotoaging is a severe skin damage that occurs as a result of exposure to external elements, primarily ultraviolet (UV) irradiation. Chronically, UV‐irradiated skin exhibits the signs of sunburn and hyperpigmentation with the destruction of connective tissues. Previously, Boesenbergia pandurata (B. pandurata) and its active compound panduratin A showed antiphotoaging activities in vitro and in vivo.ObjectiveThe aim of this study was to investigate the clinical efficacy of B. pandurata intake on skin hydration, gloss, wrinkling, and elasticity.MethodsA double‐blind, placebo‐controlled trial was conducted to clinically evaluate the effect of B. pandurata ethanol extract (BPE) containing 8% of panduratin A on human skin hydration, gloss, wrinkling, and elasticity. Ninety‐two subjects were randomly assigned to receive tablets containing either BPE or placebo for 12 weeks.ResultsThe test group had significantly increased skin hydration and gloss and decreased wrinkling compared to the placebo group at 12 weeks. There was no significant difference in skin elasticity between the two groups; however, the increment rate in the test group was higher than that in the placebo group at 12 weeks. None of the subjects developed adverse symptoms during the study period.ConclusionThese results suggest that BPE can be used as a nutraceutical or nutricosmetic material for improving human skin hydration, gloss, and wrinkling.
Factors associated with mucosal dryness in multiple regions and skin: A web‐based study in women
Authors: Ito Kayoko , Takamatsu Kiyoshi , Nohno Kaname , Sugano Aki , Funayama Saori , Katsura Kouji , Kaneko Noboru , Ogawa Mariko , Meurman Jukka H. , Inoue Makoto 
Published: April 2017

AbstractAimWe hypothesized that feeling mucosal dryness in one body region and the skin may be associated with dryness in other regions and that there are common background factors for dryness. In an earlier web‐based survey, we reported prevalence figures of dry eyes, nose, mouth, skin, and vagina. In the present study, additional analyses were made to investigate the factors associated with dryness in each region, and simultaneous dryness in multiple regions.MethodsA web‐based questionnaire was completed by 310 Japanese women. The questions included dryness of the eyes, nose, mouth, vagina, and skin. Menopausal and other symptoms were also addressed. Multiple logistic regression modeling was performed to identify factors associated with dryness in each region and in multiple dry regions.ResultsDry eyes were associated with dryness in the nose and with headache; dry nose was associated with dryness in the vagina and eyes; dry mouth was associated with sticky mouth symptom and dryness of the nose; dry skin was associated with use of xerogenic medications and vaginal discharge; and dryness of the vagina was associated with vaginal itchiness and dry nose. Vaginal discharge (odds ratio, 9.64; 95% confidence interval, 3.15–29.51) and sticky mouth (odds ratio, 6.35; 95% confidence interval, 1.29–31.29) were further associated with dryness in multiple regions.ConclusionThe present results confirmed our study hypothesis by showing that dryness in one region was clearly associated with that in another or in multiple regions. The result implies the need for holistic diagnosis and counseling for patients with dryness complaints.
Accuracy and response time of dual biomarker model of insulin‐like growth factor binding protein‐1/ alpha fetoprotein (Amnioquick duo+) in comparison to placental alpha‐microglobulin‐1 test in diagnosis of premature rupture of membranes
Authors: Eleje George Uchenna , Ezugwu Euzebus Chinonye , Eke Ahizechukwu Chigoziem , Ikechebelu Joseph Ifeanyichukwu , Ezeama Chukwuemeka Okwudili , Ezebialu Ifeanyichukwu Uzoma , Ojiegbe Nnabuike Okechukwu , Obiora Chukwudi Celestine , Okafor Charles Ikechukwu , Udigwe Gerald Okanandu , Nwosu Betrand Obi , Ezugwu Frank O. 
Published: April 2017

AbstractAimThe aim of this study was to determine accuracy and response time of duo of insulin‐like growth factor binding protein‐1 (IGFBP‐1)/alpha‐fetoprotein (Amnioquick duo+) versus placental alpha‐microglobulin‐1 (PAMG‐1) in diagnosing premature rupture of membranes (PROM).MethodsA multicenter prospective study was conducted among women with features suggestive of PROM between 24 and 42 gestational weeks (GW). PROM was confirmed post‐delivery based on presence of any two of these criteria: delivery within 48 h to 7 days, chorioamnionitis, membranes overtly ruptured at delivery, and adverse perinatal outcomes strongly correlated with prolonged PROM. Response time analysis was also done. Outcome measures included specificity, sensitivity, positive predictive value, negative predictive value, accuracy, and response time for both tests.ResultsSensitivity, specificity, and accuracy for Amnioquick duo+ were 97.9%, 97.6%, and 97.9%, which were higher than the levels for PAMG‐1, of 95.3%, 90.0%, and 95.7%, respectively (not significant). Accuracy of Amnioquick duo+ versus PAMG‐1 in equivocal (pooling = negative) cases was (98.4% vs 96.8%) at ≥34 GW but each was 100.0% at <34 GW (not significant). Overall diagnostic concordance rate of Amnioquick duo+ and PAMG‐1 was 97.0% and both have equal positive predictive value (99.5%). Response time analysis showed that the overall response time of PAMG‐1 was 4.5% higher than that of Amnioquick duo+.ConclusionThis is the largest study to date to reveal that Amnioquick duo+ and PAMG‐1 have a comparatively high diagnostic accuracy in identifying women with PROM, with a concordance rate of 97.0%. The diagnostic response time of Amnioquick duo+ appears shorter. In equivocal cases, accuracy of Amnioquick duo+ was equal to that of the PAMG‐1.
Comparing the long‐acting and short‐acting forms of gonadotropin‐releasing hormone agonists in the long protocol of IVF/ICSI Cycles: A retrospective study
Authors: Duan Liyan , Bao Shihua , Li Kunming , Teng Xiaoming , Hong Ling , Zhao Xiaoyu 
Published: April 2017

AbstractAimThis study aimed to compare the efficacy of long‐ and short‐acting gonadotropin‐releasing hormone agonist on clinical outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) long protocol cycles.MethodsIn this retrospective study, 478 patients were enrolled from October 2012 to November 2014. The pituitary downregulation result, serum hormone levels, gonadotropin (Gn) dose during controlled ovarian hyperstimulation, and outcome of IVF/ICSI–embryo transfer were compared between the two groups.ResultsCompared with the long‐acting group, in the short‐acting group the duration of downregulation and stimulation was significantly shorter; the total Gn doses, cost of an IVF cycle, rate of ovarian hyperstimulation syndrome, superior‐quality embryo rate, and implantation rate were significantly lower; and the serum luteinizing hormone concentrations on the day of Gn and human chorionic gonadotropin administration were significantly higher. The serum estradiol level on the day of human chorionic gonadotropin was higher in the long‐acting group. However, no significant differences were noted in other parameters.ConclusionThe long‐acting group was associated with greater amounts of Gn and a longer duration of use for ovarian stimulation. This increased the cost per IVF cycle and may have had a detrimental effect on the pregnancy outcome because of a subsequent increase in the rate of ovarian hyperstimulation syndrome and decrease in the superior‐quality embryo rate and implantation rate.
Is mean platelet volume a better biomarker in pre‐eclampsia?
Authors: Vilchez Gustavo , Lagos Moraima , Kumar Komal , Argoti Pedro 
Published: April 2017

AbstractAimPlatelet activation and destruction is a well recognized feature of pre‐eclampsia, but the current literature is contradictory regarding the role of mean platelet volume (MPV) in the diagnosis of this condition. We investigated whether MPV, compared with other routine laboratory markers such as platelet count, is a more significant biomarker of pre‐eclampsia, giving special attention to the intrapartum period.MethodsBiochemical and hematological markers along pregnancy including MPV were compared retrospectively between pre‐eclampsia and matched controls. Laboratory marker data were compared using independent t‐test. A logistic regression model was used to compare the strength of the associations of MPV and other routine markers such as platelet count with pre‐eclampsia. Receiver operating characteristic curves were plotted.ResultsThere were a total of 150 cases of pre‐eclampsia and 297 controls. In the pre‐eclampsia group, there were 60 cases of mild pre‐eclampsia (40.0%); 84, severe (56.0%); and six of eclampsia (4.0%). MPV was significantly higher in the pre‐eclampsia than in the control group (11.3 ± 1.0 vs 10.1 ± 0.8 fL, P = 0.002). On multivariate analysis, MPV was the only statistically significant biomarker of pre‐eclampsia (OR, 4.5; 95%CI: 1.5–13.7), and severe pre‐eclampsia (OR, 6.2; 95%CI: 1.6–24.6); performing superiorly to platelet count.ConclusionsMean platelet volume is a more significant biomarker of pre‐eclampsia. It is more significantly associated with this condition than other routinely measured laboratory markers such as platelet count. MPV is routinely obtained on complete blood cell count and its utilization in the assessment of pre‐eclampsia in a clinical setting should continue to be evaluated.
Bilateral femoral neck fractures resulting from pregnancy‐associated osteoporosis showed bone marrow edema on magnetic resonance imaging
Authors: Kasahara Kyoko , Kita Nobuyuki , Kawasaki Taku , Morisaki Shinsuke , Yomo Hiroko , Murakami Takashi 
Published: April 2017

AbstractFemoral neck fractures resulting from pregnancy‐associated osteoporosis is a rare condition. Herein, we report an undoubted case of pregnancy‐associated osteoporosis in a 38‐year‐old primiparous patient with pre‐existing anorexia nervosa who suffered bilateral femoral neck fractures in the third trimester and early post‐partum period. Magnetic resonance imaging revealed femoral neck fractures as well as diffuse marrow edema involving both femoral heads, which are considered under ordinary circumstances as characteristic imaging findings of transient osteoporosis of the hip. Based on our experience, we propose that pregnancy‐associated osteoporosis might be present in femoral neck fractures attributed to transient osteoporosis of the hip in pregnancy. Conversely, bone status should be carefully and accurately estimated in cases of potential transient osteoporosis of the hip in pregnancy to reduce future fracture risk.
Genital bleeding hemostasis in gynecologic neoplasm with balloon tamponade: New treatment option
Authors: Karakida Noriko , Yanazume Shintaro , Mori Marie , Uchida Natsuko , Tokudome Akio , Kobayashi Hiroaki 
Published: April 2017

AbstractGenital bleeding is the most common and serious complication in gynecologic malignancy. Different techniques are available for the control of severe bleeding, but standard treatment strategies have not been determined. Herein we report on the successful use of the balloon technique in two cases of genital bleeding in uterine neoplasm. The first case was of advanced cervical cancer with massive genital bleeding during radiotherapy. A metreurynter (mini‐metro) was inserted into the vagina and hemostasis was indirectly achieved in the vaginal hematoma. The other case was of postoperative recurrent bleeding after cervical conization. A Foley balloon catheter was inserted into the endocervical canal and balloon tamponade directly stopped the bleeding. This technique is safe for massive genital bleeding in some cases of gynecological cancer, and can be conventionally performed regardless of the facility or department. The need for invasive treatment for fatal bleeding in gynecological cancer in which gauze packing is ineffective may be avoided by balloon tamponade without serious complications.
Effect of urine creatinine level during pregnancy on dipstick test
Authors: Baba Yosuke , Furuta Itsuko , Zhai Tianyue , Ohkuchi Akihide , Yamada Takahiro , Takahashi Kayo , Matsubara Shigeki , Minakami Hisanori 
Published: April 2017

AbstractAimDipstick results for proteinuria are affected by urine concentration, and thus urine creatinine concentration ([Cr]). This study was performed to determine whether spot urine [Cr] changes significantly during pregnancy, leading to a significantly different false‐negative rate (FNR) on dipstick test between trimester.MethodsThe [Cr] and protein concentrations ([P]) were analyzed in 631 spot urine samples with negative/equivocal dipstick from 425 pregnant women. False‐negative dipstick was defined as [P] : [Cr] ratio (P/Cr) > 0.27 mg/mg.ResultsMedian [Cr] was 117 mg/dL (range, 6.5–326 mg/dL), 72 mg/dL (range, 4.3–477 mg/dL), and 73 mg/dL (range, 8.4–396 mg/dL) in the first (n = 96), second (n = 344), and third (n = 191) trimester urine samples, respectively (P = 0.000, Kruskal–Wallis). Both [P] and P/Cr increased significantly with advancing gestation. FNR 9.4% (18/191) in the third trimester was significantly higher than that of 0.0% (0/96) in the second trimester and that of 0.5% (2/344) in the third trimester. In the 20 urine samples with false‐negative dipstick, median [Cr] was 47.0 mg/dL (range, 11.0–358 mg/dL) and the proportion of samples with dilute urine, that is, [Cr] <47 mg/dL, was significantly higher than in the remaining 611 urine samples (50%, 10/20 vs 28%, 174/611, respectively, P = 0.046).ConclusionsUrine samples in the second and third trimesters were more likely to be diluted compared with the first trimester. This was associated with high FNR in third trimester urine samples.
Serum placental growth factor and soluble fms‐like tyrosine kinase 1 at mid‐gestation in healthy women: Association with small‐for‐gestational‐age neonates
Authors: Furuta Itsuko , Umazume Takeshi , Kojima Takashi , Chiba Kentaro , Nakagawa Kinuko , Hosokawa Ami , Ishikawa Satoshi , Yamada Takahiro , Morikawa Mamoru , Minakami Hisanori 
Published: April 2017

AbstractAimThis study was performed to determine the associations between serum placental growth factor (PlGF) and soluble fms‐like tyrosine kinase 1 (sFlt‐1) levels at mid‐gestation with the risk of small‐for‐gestational‐age (SGA) neonates born at gestational week (GW) ≥ 36 in healthy women.MethodsPlGF and sFlt‐1 concentrations were determined at GW 24–27 in 183 women with births at GW ≥ 36, but without gestational diabetes mellitus and hypertension.ResultsThirteen (7.1%) SGA neonates were born. Median (range) GW at blood sampling was similar between women with and without SGA (25 [24–25] and 24 [24–27], respectively, P = 0.671). Pre‐pregnancy body mass index (BMI) and PlGF levels were significantly lower in women with than without SGA, while sFlt‐1 levels and sFlt‐1 : PlGF ratio (sFlt‐1/PlGF) did not differ significantly between the two groups. PlGF and sFlt‐1/PlGF, but not BMI or sFlt‐1, showed significant correlations with birthweight z‐score; the correlation was positive for PlGF and negative for sFlt‐1/PlGF. Women with PlGF level < 10th percentile and those with sFlt‐1/PlGF level > 90th percentile showed significantly increased risk of SGA compared to those with respective counterpart characteristics; relative risk was 3.8 (95% confidence interval, 1.3–11.3; 21% [4/19] vs 5.5% [9/164]) for PlGF and 7.9 (95% confidence interval, 3.0–20.8, 33.3% [6/18] vs 4.2% [7/165]) for sFlt‐1/PlGF.ConclusionMaternal PlGF and sFlt‐1/PlGF determined during GW 24–27 were associated with the risk of SGA neonates born at GW ≥ 36, even in women with uncomplicated pregnancies.