bluuebunny/crossref_metadata_2025_split huggingface dataset:
Further analysis of fixed‐lean approaches to reinforcement schedule thinning
Authors: Chesbrough Emily A. , King Hunter , Fornah Mariatu , Quigley Shelby , Falligant John Michael 
Published: September 2024

AbstractFunctional communication training is an effective intervention for establishing an appropriate, alternative response that produces the functional reinforcer maintaining challenging behavior. Once the alternative response is established, it is differentially reinforced—typically using dense schedules—while challenging behavior is placed on extinction. After achieving clinically significant reductions in challenging behavior, reinforcement schedule thinning is conducted to promote the maintenance of the alternative response under more practical reinforcement schedules. In the current study, we compared two different methods for thinning the schedule of reinforcement for the alternative response to a terminal schedule. One method, referred to as the dense‐to‐lean (DTL) approach, involves gradually decreasing the density of alternative reinforcement over successive sessions until the terminal schedule is reached. Another method, referred to as the fixed‐lean (FL) approach, involves abruptly decreasing the density of alternative reinforcement by rapidly transitioning to the terminal schedule. Whereas the former approach has been evaluated extensively within the applied literature, the latter approach has not been the focus of much empirical work in either the clinic or the laboratory. An alternating treatment design was used to directly compare these approaches, both of which included noncontingent access to competing stimuli. Participants achieved clinically significant reductions in challenging behavior at the terminal schedule more readily with the FL than the DTL approach. The results are further discussed in terms of the efficacy and efficiency for both approaches, the potential mediating effect of competing stimuli, and implications for future research.
Synthesis and Antifungal Evaluation of Cinnamic Acid‐Geraniol Hybrids as Potential Fungicides
Authors: Huang Xiaobo , Shu Lili , Hao Nan , Wei Zhenyang , Qian Le , Tian Yuee , Cheng Zejun , Chen Genqiang , Liu Shengming , Deng Shuzhen , Guo Yashuang , Che Zhiping 
Published: September 2024

AbstractCinnamic acid and geraniol are two well‐known antifungal natural products and widely applied in food and cosmetics industries. To discover novel natural product‐based fungicide candidates with more potent activity and good ecological compatibility for the management of plant diseases, a series of cinnamic acid‐geraniol hybrids were prepared by means of molecular hybridization and their chemical structures were well confirmed by spectral analysis. The antifungal activities of the target compounds against three phytopathogenic fungi Fusarium graminearum, Gaeumannomyces graminis (Sacc.) Arx et Oliver var. tritici (Sacc.) Walker, and Valsa mali were evaluated. Among them, compounds 5 e and 5 f showed the remarkable antifungal activity against G. graminis with the EC50 values of 82.719 and 91.828 μg/mL, respectively; while compounds 5 f and 6 b exhibited the obvious antifungal activity against V. mali. It suggested that compound 5 f can be further optimized for the design of novel broad‐spectrum fungicide molecules as the secondary lead compound. In addition, some interesting structure‐antifungal activity relationships were obtained. This work will provide some reference and guidance for the further discovery of novel fungicide candidates based on cinnamic acid and geraniol.
Chemical Compositions, Molecular Docking, Anti‐Inflammatory, and Anti‐Cancer Effects of the Leaf Essential Oils Isolated from Three Species of the Rutaceae Family in Vietnam
Authors: Pham Ty Viet , Hoang Thao Xuan , Do Bich Hang , Nguyen Khanh‐Quynh Thi , Nguyen Nguyen Hoai , Tran Gia‐Buu 
Published: September 2024

AbstractThree species of the Rutaceae family, including Acronychia pedunculata, Euodia lepta, and Severinia monophylla have been used in traditional medicine. However, the comparison of the chemical composition, anti‐cancer, and anti‐inflammatory effects of the leaf essential oils of these species have not been investigated yet. A total of 38 compounds were identified via gas chromatography‐mass spectrometry, comprising 96.5–99.8 % of the total composition. Both A. pedunculata and E. lepta essential oils exhibited strong inhibitory effects against cancer cells (IC50: 59.04–97.52 μg/mL) while that of S. monophylla showed a lower anti‐cancer effect (IC50>100 μg/mL). Among three essential oils, only the E. lepta leaf oil demonstrated a high anti‐inflammatory effect on LPS‐stimulated macrophages (IC50=6.47±0.65 μg/mL), while the others showed a moderate anti‐inflammatory effect (IC50>50 μg/mL). Molecular docking studies also suggested the binding potential of the key compounds from three essential oils against inducible nitric oxide synthase and cyclooxygenase‐2, two proteins associated with inflammatory response, with the negative energies ranging from −41.0 to −71.9 kcal/mol. The present findings suggest the leaf essential oils from these species as potential medicines for treatment of cancer or inflammation associated diseases, especially the ones from A. pedunculata and E. lepta oils.
Selenol Switch Assay for Selenoprotein Derivatization
Authors: Wei Haopai , Zhang Baoxin , Shi Suntao , Wang Zhiyuan , Zhang Fang , Fang Jianguo 
Published: September 2024

AbstractSelenoproteins are a class of protein that have selenocysteine (Sec) residues, and essential for diverse cellular functions. Although the human genome encodes 25 selenoproteins, nearly half of these selenoproteins’ function is not clear. This is largely due to the lack of convenient methods to study selenoproteins. We report in this work a novel Selenol Switch assay to exclusively derivatize selenoproteins. The Selenol Switch assay relies on the selective conversion of the Sec residue to the electrophilic dehydroalanine (DHA) residue, which is then labeled by nucleophiles. The multiple reactions of the Selenol Switch assay are readily performed in a single test tube, and the conversion yield is nearly quantitative. The abundance of selenoproteins in mouse tissues determined by the Selenol Switch assay is consistent with that from the classical ICP‐MS assay, validating the reliability of the Selenol Switch assay in studying selenoproteins.
Differences between sexes in STEMI treatment and outcomes with contemporary primary PCI
Authors: Savage Michael L. , Hay Karen , Vollbon William , Murdoch Dale J. , Hammett Christopher , Crowhurst James , Poon Karl , Poulter Rohan , Walters Darren L. , Denman Russell , Ranasinghe Isuru , Raffel Owen Christopher 
Published: September 2024

AbstractBackgroundHistorically, differences in timely reperfusion and outcomes have been described in females who suffer ST‐segment elevation myocardial infarction (STEMI). However, there have been improvements in the treatment of STEMI patients with contemporary Percutaneous Coronary Intervention (PCI) strategies.MethodsComparisons between sexes were performed on STEMI patients treated with primary PCI over a 4‐year period (January 1, 2017–December 31, 2020) from the Queensland Cardiac Outcomes Registry. Primary outcomes were 30‐day and 1‐year cardiovascular mortality. Secondary outcomes were STEMI performance measures. The total and direct effects of gender on mortality outcomes were estimated using logistic and multinomial logistic regression models.ResultsOverall, 2747 (76% male) were included. Females were on average older (65.9 vs. 61.9 years; p < 0.001), had longer total ischemic time (69 min vs. 52 min; p < 0.001) and less achievement of STEMI performance targets (<90 min) (50% vs. 58%; p < 0.001). There was no evidence for a total (odds ratio [OR] 1.3 (95% confidence interval [CI]: 0.8–2.2; p = 0.35) or direct (adjusted OR 1.2 (95% CI: 0.7–2.1; p = 0.58) effect of female sex on 30‐day mortality. One‐year mortality was higher in females (6.9% vs. 4.4%; p = 0.014) with total effect estimates consistent with increased risk of cardiovascular mortality (Incidence rate ratio [IRR]: 1.5; 95% CI: 1.0–2.3; p = 0.059) and noncardiovascular mortality (IRR: 2.1; 95% CI: 0.9–4.7; p = 0.077) in females. However, direct (adjusted) effect estimates of cardiovascular mortality (IRR: 1.0; 95% CI: 0.6–1.6; p = 0.94) indicated sex differences were explained by confounders and mediators.ConclusionSmall sex differences in STEMI performance measures still exist; however, with contemporary primary PCI strategies, sex is not associated with cardiovascular mortality at 30 days or 1 year.
Efficient Ru/Y2O3 Catalyst Derived from Ru Nanoparticles on Yttrium Carbonate for Production of Hydrogen from Ammonia Decomposition
Authors: Feng Ji , Wan Ningbo , Ju Xiaohua , Liu Lin , Bai Liguang , Zhao Xiaodong , He Teng 
Published: September 2024

AbstractHydrogen production from the decomposition of ammonia is one of the promising methods to solve the problem of hydrogen storage and transportation. Currently, ruthenium‐based catalysts are widely recognized as highly active catalysts for ammonia decomposition reactions. Here, Ru nanoparticles (NPs) on yttrium oxide derived from yttrium carbonate precursor (c‐Y2O3) was successfully prepared by the impregnation method. A hydrogen production rate up to 31.5 mmol gcat−1 min−1 can be obtained over the 5% Ru/c‐Y2O3 catalyst at 450 °C with a weight hour space velocity (WHSV) of 30000 mL gcat−1 h−1, and the activity is stable during a test period of 120 h. The catalysts were characterized by a series of techniques such as TEM, CO‐chemisorption, XPS, and CO2‐TPD. Characterization results reveal that high metal dispersion of Ru NPs, strong metal support interaction, high concentration of oxygen vacancies, and suitable basicity of Ru/c‐Y2O3 catalyst all strongly influence on the catalytic performance in ammonia decomposition. NH3 temperature‐programmed surface reaction (NH3‐TPSR) results indicate that a strong NH3 adsorption activation and binding desorption of nitrogen ability on the surface of Ru/c‐Y2O3 catalysts are also beneficial for the high activity. These results provide a reference for the design of efficient Ru‐based ammonia decomposition catalysts for hydrogen production by tuning the precursor of Y2O3 support.
Stereoselective Gridization of Ladder‐Type Grids with Four Chiral Centers
Authors: Li Yang , Pu Yueting , Zhang Zheng , Tao Fangju , Li Xiaoyan , Zhang Jingrui , Chen Xin , Gao Yuezheng , Wei Ying , Xie Linghai 
Published: September 2024

Comprehensive SummaryTo address the stereoselective synthesis challenge in π‐stacked grids with four chiral centers, we utilized coplanar and highly rigid 11,12‐dihydroindeno[2,1‐a]fluorene‐11,12‐diol and 2,2'‐bithiophene as synthons, employing Friedel‐Crafts gridization (FCG). Leveraging the supramolecular interactions of S···S and π···π within the thiophene moiety, along with the steric effect of the 11,12‐dihydroindeno[2,1‐a]fluorene scaffold, we successfully achieved the exclusive generation of a single isomer of Ladder‐type π‐stacked grids (LGs‐IF) containing six theoretical isomers. By subsequently substituting 2,2'‐bithiophene with thiophene/bithiophene derivatives as synthons, we maintained an exceptionally high level of stereoselectivity. This study introduces a novel approach for the stereo‐controlled preparation of grids involving multi‐chiral centers.
Tumor‐Associated Carbohydrate Antigen 19–9 (CA 19–9), a Promising Target for Antibody‐Based Detection, Diagnosis, and Immunotherapy of Cancer
Authors: Nakisa Athar , Sempere Lorenzo F. , Chen Xi , Qu Linda T. , Woldring Daniel , Crawford Howard C. , Huang Xuefei 
Published: September 2024

AbstractCarbohydrate antigen 19–9 (CA 19–9) also known as sialyl Lewis A is a tetrasaccharide overexpressed on a wide range of cancerous cells. CA 19–9 has been detected at elevated levels in sera of patients with various types of malignancies, most prominently pancreatic ductal adenocarcinoma. After its identification in 1979, multiple studies have highlighted the significant roles of CA 19–9 in cancer progression, including facilitating extravasation and eventually metastases, proliferation of cancer cells, and suppression of the immune system. Therefore, CA 19–9 has been considered an attractive target for cancer diagnosis, prognosis, and therapy. This review discusses the synthesis of CA 19–9 antigen, elicitation of antibodies through vaccination, development of anti‐CA 19–9 monoclonal antibodies, and their applications as imaging tracers and therapeutics for a variety of CA 19–9‐positive cancer.
Relative Bioavailability of Sotorasib Following Administration as a Water Dispersion to Healthy Subjects and Compatibility With Enteral Administration
Authors: Cardona Panli , Spring Marintan , Bao Jiemin , Xie Yong , Houk Brett 
Published: September 2024

AbstractSotorasib is approved to be taken as 960 mg orally once daily (8 × 120‐mg tablets) for the treatment of KRAS G12C‐mutated nonsmall cell lung cancer. Dispersion of tablets in water could be an alternative method for patients who require a liquid formulation due to dysphagia and enteral administration. A clinical study was conducted to assess the pharmacokinetics of 960 mg of sotorasib administered as tablets and as tablets dispersed in water in healthy volunteers. Each subject received 960 mg of sotorasib by mouth, as tablets and as tablets dispersed in water on Days 1 and 4. Sotorasib median time to maximum observed plasma concentration was similar when administered as tablets and as tablets predispersed in water. The geometric least squares mean ratios (water dispersion/tablets) for area under the concentration‐time curve from time 0 extrapolated to infinity and maximum observed plasma concentration were 1.049 and 1.080, respectively. Sotorasib 960 mg was well tolerated. Administration of 960 mg of sotorasib as tablets predispersed in water achieved similar systemic exposures to that of sotorasib administered as oral tablets. In vitro evaluations were performed to assess the feasibility of administering sotorasib through an enteral feeding tube. Approximately 98% of sotorasib was recovered, with no new impurities, from enteral feeding tubes. Collectively, these results support that sotorasib can be administered by mouth and via enteral feeding tubes as tablets predispersed in water.
Preparation of Novel Hierarchical Catalysts by Simultaneous Generation of β‐Zeolite and Mesoporous Silica for Catalytic Cracking
Authors: Oshimura Haruna , Tanaka Shuuma , Nagata Shouya , Matsuura Shinya , Hashimoto Tadanori , Ishihara Atsushi 
Published: September 2024

AbstractThe gel skeletal reinforcement (GSR) method was applied at the preparation stage of β‐zeolite to prepare a novel hierarchical catalyst. A solution of hexamethyldisiloxane (HMDS) and acetic anhydride, a GSR reagent, was added to the mixture of colloidal silica, sodium aluminate, tetraethylammonium hydroxide, sodium hydroxide and water, and successive aging and hydrothermal treatment gave microporous β‐zeolite surrounded by mesoporous silica like core‐shell structure. Its properties were characterized by XRD, nitrogen adsorption and desorption, NH3‐TPD, TEM, and TG‐DTA measurements, and further characteristics of the catalysts produced were clarified by the catalytic cracking of n‐dodecane. The hierarchical structure of microporous zeolite and mesoporous silica was shown from GSR‐2.9HS−H‐Beta to GSR‐3.2HS−H‐Beta, where the molar ratio of HMDS and silica source of β‐zeolite was 2.9~3.2 : 100. It was found that in the catalytic cracking of n‐dodecane, the relative activity (the conversion per the amount of zeolite crystals) increased with the increase in mesopore volume and surface area. The result indicated that the introduction of mesopores was effective even in catalytic cracking of small molecule of n‐dodecane.
Identifying the role of absorptive capacity in the relationship between quality management and sustainability: Evidence from the tourism industry
Authors: López‐Gamero María D. , Molina‐Azorín José F. , Tarí Juan José , Pereira‐Moliner Jorge 
Published: September 2024

AbstractFirms need to develop dynamic capabilities to anticipate, adapt and respond to a changing competitive environment. Quality management, absorptive capacity and sustainability can act as dynamic capabilities, helping firms to adapt better and more quickly to new stakeholder demands. Some dynamic capabilities can help develop others. The aim of this paper is to analyse the role of quality management and absorptive capacity as enablers and drivers of environmental, economic and social sustainability development, and to study the mediating role of absorptive capacity in the relationship between quality management and the three dimensions of sustainability. Through structural equation modelling and using data from Spanish hotels, this study adds value to the dynamic capabilities theory by empirically demonstrating that quality management and absorptive capacity, used together, positively influence (directly or indirectly) the environmental, economic and social sustainability of hotels in order to reduce their environmental impact, and improve the social well‐being of stakeholders and the economic development of the region.
Oxygen‐doped FeP on Ti Foil with Ti3O Interlayer for Efficient and Durable Electrolysis
Authors: Yuan Yanqi , Zhong Boan , Wang Kun , Liu Jing , Zhao Liping , Chen Han , Sun Yanting , Zhang Peng , Gao Lian 
Published: September 2024

AbstractThe development of electrocatalysts with low cost, high efficiency, and long‐term durability is crucial for advancing green hydrogen production. Transition metal phosphides (TMPs) have been proved to be efficient electrocatalyst, while the improvement in the performance and durability of the TMPs remains a big challenge. Employing atmospheric pressure chemical vapor deposition (APCVD) and phosphorization, FeP/Ti electrodes are fabricated featuring controllable oxygen ingredients (O‐FeP/Ti). This manipulation of oxygen content fine‐tunes the electronic structure of the catalyst, resulting in improved surface reaction kinetics and catalytic activity. The optimized O‐FeP‐400/Ti exhibits outstanding HER activity with overpotentials of 142 and 159 mV at −10 mA cm−2 in 0.5 M H2SO4 and 1 M KOH, respectively. Notably, the obtained O‐FeP/Ti cathode also displays remarkable durability of up to 200 h in acidic electrolyte with surface topography remaining intact. For the first time, the low‐valence titanium oxide (Ti3O) interlayer is identified in the composite electrode and ascribed for the superior connection between Ti substrate and the surface O‐FeP catalyst, as supported by experimental results and density functional theory (DFT) analysis. This work has expanded the potential applications of transition metal phosphides (TMPs) as a cost‐effective, highly efficient and durable catalyst for water splitting.
Unity Power Factor Control of Single‐Phase Boost Rectifier Based on Dual Heterodyne Method
Authors: Zhong Liping , Hu Song 
Published: September 2024

ABSTRACTThis paper proposes a novel control method to achieve the true unity power factor for a single‐phase boost rectifier. Firstly, the phase difference between the voltage and current on the AC side is calculated by the heterodyne method. Secondly, this phase difference is fed into an integral regulator to get a phase shift angle. Finally, by using the heterodyne method once again, the AC side current is phase‐shifted and used as the modulation signal for the single‐phase full bridge rectifier circuit and ultimately yields a unity power factor. The experimental results verify the effectiveness and feasibility of this strategy.
Applications of artificial intelligence in geothermal resource exploration: A review
Authors: AlGaiar Mahmoud , Hossain Mamdud , Petrovski Andrei , Lashin Aref , Faisal Nadimul 
Published: September 2024

AbstractArtificial intelligence (AI) has become increasingly important in geothermal exploration, significantly improving the efficiency of resource identification. This review examines current AI applications, focusing on the algorithms used, the challenges addressed, and the opportunities created. In addition, the review highlights the growth of machine learning applications in geothermal exploration over the past decade, demonstrating how AI has improved the analysis of subsurface data to identify potential resources. AI techniques such as neural networks, support vector machines, and decision trees are used to estimate subsurface temperatures, predict rock and fluid properties, and identify optimal drilling locations. In particular, neural networks are the most widely used technique, further contributing to improved exploration efficiency. However, the widespread adoption of AI in geothermal exploration is hindered by challenges, such as data accessibility, data quality, and the need for tailored data science training for industry professionals. Furthermore, the review emphasizes the importance of data engineering methodologies, data scaling, and standardization to enable the development of accurate and generalizable AI models for geothermal exploration. It is concluded that the integration of AI into geothermal exploration holds great promise for accelerating the development of geothermal energy resources. By effectively addressing key challenges and leveraging AI technologies, the geothermal industry can unlock cost‐effective and sustainable power generation opportunities.
A Pd(II) Complex Exhibiting Tetradentate NHC‐Phosphine Ligand: On Route to Unconventional Phosphonium Ylide Derivatives
Authors: Willot Jérémy , Taakili Rachid , Ameskal Mohammad , Duhayon Carine , Lugan Noël , Canac Yves , Valyaev Dmitry A. 
Published: September 2024

AbstractUnusual open‐chain tetradentate NHC‐phosphine pre‐ligand [Ph2PCH(Ph)ImCH2ImC(H)PhPPh2](BF4)2 was prepared in a good yield by metal‐mediated approach starting from Mn(I) complex [Cp(CO)2Mn(η2‐Ph2P=C(H)Ph)](BF4) and bis(imidazole) derivative ImCH2Im. Its reaction with Pd(OAc)2 afforded dicationic Pd(II) complex of bis(NHC)bis(phosphine) ligand adopting κ4PĈĈP coordination mode as a mixture of two diastereomers. The deprotonation of the C(H)Ph ligand bridge in the latter using KN(SiMe3)2 as base provided stable complex exhibiting unconventional phosphonium ylide moiety, whereas all attempts to detect the corresponding bis(ylide) derivative failed.
Organocatalyzed Electrochemical Enantioselective α‐Alkylation of Aldehydes with 9,10‐Dihydroacridines
Authors: He Jin‐Yu , Wang Na‐Na , Zhao Ruinan , Kong Ling‐Xuan , Zhu Cuiju , Mei Tian‐Sheng , Xu Hao 
Published: September 2024

AbstractAcridine scaffolds are present in biological and pharmaceutical molecules. However, achieving asymmetric functionalization of acridines remains challenging without an efficient and highly stereoselective approach. Here we demonstrate a facile electrooxidative asymmetric dehydrogenative coupling reaction of 9,10‐dihydroacridines with aldehydes. This method offers a sustainable and effective route to various chiral α‐alkylation of 9,10‐dihydroacridines in high yields with excellent enantioselectivities facilitated by readily available aminocatalyst. Detailed mechanistic studies and cyclic voltammetric analyses reveal that this asymmetric electrochemical reaction proceeds through redox‐mediated oxidation, followed by a nucleophilic attack with concurrently generated enamine. We anticipate that our research will open avenues for promising exploration in organocatalyzed electrochemical enantioselective transformations.
Metal‐Free α‐(Hetero)Arylation of Amides Enabled Access to Diaryl Acetamides via Umpolung
Authors: Zhang Wei , Han Shuai , Zeng Yao‐Fu , Han Fang 
Published: September 2024

AbstractA metal‐free α‐(hetero)arylation of aryloxy‐activated amides for access to diaryl‐acetamides was developed. This base‐mediated arylation reaction features mild reaction conditions and broad functional groups tolerance. The scope of (hetero)arylating reagents includes indoles, pyrroles, furan, N, N‐dimethylanilines, and electron‐rich benzenes. The applicability of this protocol was demonstrated by the gram‐scale experiment and the derivatization of the target products.