bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive evaluation of decellularized porcine corneal after clinical transplantation
Authors: Shi Yan , Bikkuzin Timur , Song Zhen , Jin Xin , Jin Hao , Li Xinlei , Zhang Hong 
Published: September 2017

AbstractCorneal disease is the second most common blinding disease in the world. The shortage of cornea donors has become the greatest challenge in curing corneal disease. Decellularized porcine corneas have the potential to be clinically applied as a substitute for human cornea in lamellar keratoplasty. Porcine corneas will help relieve the cornea donor shortage. To comprehensively evaluate the characteristics of the grafts and the effect of the decellularized porcine cornea on the host cornea after clinical transplantation, we assessed the microstructure of the transplanted decellularized porcine corneal tissues. Through the analysis of the microstructure of the tissues by H&E staining, TEM and immunofluorescence of anti‐human vimentin, anti‐pig vimentin,IL‐1, IL‐2, IL‐3, IL‐6, IL‐8, INF‐γ, and TNF‐α immunofluorescence staining, we found that despite the slight rejection that occurred, the porcine cornea has good biocompatibility and can provide a scaffold for cell growth. Genetic analysis using Solexa sequencing of the samples showed that decellularized porcine corneas cannot affect genes in patients’ corneas. Decellularized porcine corneas are effective biological materials for use in corneal transplantation.
Polycarp, Paul, and the Letters to Timothy
Authors: Lookadoo Jonathon 
Published: September 2017

Abstract
Building on recent discussions of the Paulusbild in the second century, this study argues that Polycarp’s image of Paul is framed by his use of 1-2 Timothy. The essay first examines Polycarp’s allusions to 1 Tim 6:7, 10, similarities to the household code in 1 Tim 2:8-3:13, and the reversal of a phrase in 2 Tim 4:10. Two conclusions are then drawn. First, Polycarp’s use of language from 1-2 Timothy fits loosely within the standards of ancient quotation. Second, Polycarp’s depiction of Paul as a suffering, pastoral figure is closely tied to his use of language from 1-2 Timothy.
The Fall of Men and the Lust of Women in Seneca’s Epistle 95 and Paul’s Letter to the Romans
Authors: Dodson Joseph R. 
Published: September 2017

Abstract
Seneca’s invective against the sexual misconduct in the Roman Empire as part of his decline narrative is a neglected parallel to Rom 1:26-27. Its resonances, however, give more support to Ben Witherington’s comment about specifically situating Romans 1 within the context of Seneca’s castigation of the lechery in Rome. Moreover, the parallels with Epistle 95 reinforce an excessive lust view of Rom 1:26-27.
Disciplined Exaggeration
Authors: Kloppenborg John S. 
Published: September 2017

Abstract
Comparison in the study of religion, in particular the study of the early Jesus movement has had an odd history, serious comparison often being eschewed and dismissed in the interest of preserving claims to the sui generis character of early Christianity. This paper argues that comparison should be regarded as heuristic rather than genealogical, and illustrates this by examining two forms of comparison, analytic and illustrative, in each case mobilizing comparisons of early Pauline groups and their practices with Graeco-Roman associations and the fiscal practices of Greek cities.
Epidemiology of Posterior Glenohumeral Instability in a Young Athletic Population
Authors: Lanzi Joseph T. , Chandler Philip J. , Cameron Kenneth L. , Bader Julia M. , Owens Brett D. 
Published: September 2017

Background:While several studies have observed the incidence of posterior glenohumeral instability in selected populations, there are no data from large-scale population-based studies with corresponding athletic exposure data to calculate incidence rates (IRs) and associated risk factors.Purpose:To determine risk factors for posterior glenohumeral instability within the physically active population at the United States Military Academy.Study Design:Descriptive epidemiology study.Methods:A longitudinal cohort study was performed over a 6-year period from 2006 to 2012 at the United States Military Academy utilizing the Cadet Illness and Injury Tracking System. Exposure data were collected from daily attendance data documented for every practice and game at the intramural, club, or varsity sport level. The primary outcomes calculated were the IRs of posterior glenohumeral joint instability per 1000 person-years at risk and per 1000 athlete-exposures. IR ratios and confidence intervals were calculated between male and female cadets and between intercollegiate and intramural athletes.Results:Between 2006 and 2012, there were 1348 shoulder injuries in total, with 633 instability events. During the study period, 113 posterior shoulder instability injuries (17.9% of instability events) and 26,408 person-years at risk were documented, for an overall IR of 4.28 per 1000 person-years. The overall IR of posterior instability was 0.08 per 1000 athlete exposures. In male athletes, 105 sustained a posterior shoulder instability event, for an IR of 4.67 per 1000 person-years. Female athletes were less likely to sustain a posterior instability event, accounting for only 8 events, for an IR of 2.04 per 1000 person-years. A total of 6670 athletes were at risk for posterior shoulder instability injury during the study period. A total of 55 injuries were documented, for an IR of 8.25 per 1000 person-years. Intercollegiate wrestlers had the highest IR: 34.15 per 1000 person-years. The sport with the highest injury rate among intramural sports was football, at 2.79 per 1000 person-years. Three athletes had a history of a posterior shoulder dislocation, while no significant difference was found for subluxation versus pain as the presenting symptom. Of the 113 posterior shoulder instability injuries, 77.0% required surgical stabilization. All injuries associated with weight lifting required surgical stabilization.Conclusion:Among athletes, intercollegiate athletes are at an increased risk of posterior glenohumeral instability when compared with intramural athletes. Intercollegiate athletes and weight lifters demonstrate a high likelihood of requiring surgical treatment as compared with intramural athletes.
A hybrid composite system of biphasic calcium phosphate granules loaded with hyaluronic acid–gelatin hydrogel for bone regeneration
Authors: Faruq Omar , Kim Boram , Padalhin Andrew R , Lee Gun Hee , Lee Byong-Taek 
Published: September 2017

An ideal bone substitute should be made of biocompatible materials that mimic the structure, characteristics, and functions of natural bone. Many researchers have worked on the fabrication of different bone scaffold systems including ceramic–polymer hybrid system. In the present study, we incorporated hyaluronic acid–gelatin hydrogel to micro-channeled biphasic calcium phosphate granules as a carrier to improve cell attachment and proliferation through highly interconnected porous structure. This hybrid system is composed of ceramic biphasic calcium phosphate granules measuring 1 mm in diameter with seven holes and hyaluronic acid–gelatin hydrogel. This combination of biphasic calcium phosphate and hyaluronic acid–gelatin retained suitable characteristics for bone regeneration. The resulting scaffold had a porosity of 56% with a suitable pore sizes. The mechanical strength of biphasic calcium phosphate granule increased after loading hyaluronic acid–gelatin from 4.26 ± 0.43 to 6.57 ± 0.25 MPa, which is highly recommended for cancellous bone substitution. Swelling and degradation rates decreased in the hybrid scaffold compared to hydrogel due to the presence of granules in hybrid scaffold. In vitro cytocompatibility studies were observed by preosteoblasts (MC3T3-E1) cell line and the result revealed that biphasic calcium phosphate/hyaluronic acid–gelatin significantly increased cell growth and proliferation compared to biphasic calcium phosphate granules. Analysis of micro-computed tomography data and stained tissue sections from the implanted samples showed that the hybrid scaffold had good osseointegration and better bone formation in the scaffold one and two months postimplantation. Histological section confirmed the formation of dense collagenous tissue and new bone in biphasic calcium phosphate/hyaluronic acid–gelatin scaffolds at two months. Our study demonstrated that such hybrid biphasic calcium phosphate/hyaluronic acid–gelatin scaffold is a promising system for bone regeneration.
The Retention of Expertise and Productivity in State Legislative Committees
Authors: Makse Todd 
Published: September 2017

AbstractLegislative committees rely on the expertise and experience of their members, but instability in committee systems threatens the enhancements in productivity associated with specialization. This can occur in two ways, both of which are more common in state legislative committees than they are in Congress. First, membership retention on committees is generally lower, even after accounting for differing levels of legislative turnover across legislatures. Second, many state legislative committee systems undergo reorganization between sessions, changing the policy jurisdictions, and, therefore, the applicability of members' previously developed expertise. In this article, I examine the consequences of these two sources of committee instability on legislative output in 14 state legislatures. I find that both membership retention and jurisdictional reorganization significantly affect the number of bills processed through committees and the number of bills ultimately enacted. These linkages are also conditioned on several committee and institutional factors, particularly legislative turnover. Last, I find a weaker but discernible effect of membership retention on committees' propensity to perform their gatekeeping role.
Echocardiographic assessment with right ventricular function improvement following ultrasound-accelerated catheter-directed thrombolytic therapy in submassive pulmonary embolism
Authors: Doheny Charles , Gonzalez Lorena , Duchman Stanley M , Varon Joseph , Bechara Carlos F , Cheung Mathew , Lin Peter H 
Published: September 2017

Introduction The objective of this study was to evaluate the efficacy of ultrasound-accelerated catheter-directed thrombolytic therapy in patients with submassive pulmonary embolism. Methods Clinical records of 46 patients with submassive pulmonary embolism who underwent ultrasound-accelerated catheter-directed pulmonary thrombolysis using tissue plasminogen activator, from 2007 to 2017, were analyzed. All patients experienced clinical symptoms with computed tomography evidence of pulmonary thrombus burden. Right ventricular dysfunction was present in all patients by echocardiographic finding of right ventricle-to-left ventricle ratio > 0.9. Treatment outcome, procedural complications, right ventricular pressures, and thrombus clearance were evaluated. Follow-up evaluation included echocardiographic assessment of right ventricle-to-left ventricle ratio at one month, six months, and one year. Results Technical success was achieved in all patients ( n = 46, 100%). Our patients received an average of 18.4 ± 4.7 mg of tissue plasminogen activator using ultrasound-accelerated thrombolytic catheter with an average infusion time of 16.5± 5.4 h. Clinical success was achieved in all patients (100%). Significant reduction of mean pulmonary artery pressure occurred following the treatment, which decreased from 36 ± 8 to 21 ± 5 mmHg ( p < 0.001). There were no major bleeding complications. All-cause mortality at 30 days was 0%. No patient developed recurrent pulmonary embolism during follow-up. During the follow-up period, 43 patients (93%) showed improvement of right ventricular dysfunction based on echocardiographic assessment. The right ventricle-to-left ventricle ratio decreased from 1.32 ± 0.18 to 0.91 ± 0.13 at the time of hospital discharge ( p < 0.01). The right ventricular function remained improved at 6 months and 12 months of follow-up, as right ventricle-to-left ventricle ratio were 0.92 ± 0.14 ( p < 0.01) and 0.91 ± 0.15 ( p < 0.01), respectively. Conclusion Ultrasound-accelerated catheter-directed thrombolysis is a safe and efficacious treatment for submassive pulmonary embolism. It reduces pulmonary hypertension and improves right ventricular function in patients with submassive pulmonary embolism.
RETRACTED ARTICLE: A modified multilocus sequence typing protocol to genotype Kingella kingae from oropharyngeal swabs without bacterial isolation
Authors: El Houmami Nawal , Bzdrenga Janek , Pons Jean-Christophe , Minodier Philippe , Durand Guillaume André , Oubraham Anis , Ceroni Dimitri , Yagupsky Pablo , Raoult Didier , Bidet Philippe , Fournier Pierre-Edouard 
Published: September 2017

Abstract
Background
Outbreaks of Kingella kingae infection are an emerging public health concern among daycare attendees carrying epidemic clones in the oropharynx. However, genotyping of such epidemic clones from affected cases is limited by the low performance of current methods to detect K. kingae from blood samples and lack of specimens available from infected sites. We aimed at developing a modified multilocus sequence typing (MLST) method to genotype K. kingae strains from oropharyngeal samples without prior culture. We designed in silico MLST primers specific for K. kingae by aligning whole nucleotide sequences of abcZ, adk, aroE, cpn60, recA, and gdh/zwf genes from closely related species belonging to the Kingella and Neisseria genera. We tested our modified MLST protocol on all Kingella species and N. meningitidis, as well as 11 oropharyngeal samples from young children with sporadic (n = 10) or epidemic (n = 1) K. kingae infection.

Results
We detected K. kingae-specific amplicons in the 11 oropharyngeal samples, corresponding to sequence-type 6 (ST-6) in 6 children including the epidemic cases, ST-25 in 2 children, and 3 possible novel STs (ST-67, ST-68, and ST-69). No amplicon was obtained from other Kingella species and N. meningitidis.

Conclusions
We herein developed a specific MLST protocol that enables genotyping of K. kingae by MLST directly from oropharyngeal samples. This discriminatory tool, with which we identified the first K. kingae outbreak caused by ST-6 in Europe, may be used in further epidemiological investigations.
Associations Between Sexual Orientation and Overall and Site-Specific Diagnosis of Cancer: Evidence From Two National Patient Surveys in England
Authors: Saunders Catherine L. , Meads Catherine , Abel Gary A. , Lyratzopoulos Georgios 
Published: September 2017

Purpose To address gaps in evidence on the risk of cancer in people from sexual minorities. Patients and Methods We used data from 796,594 population-based English General Practice Patient Survey responders to explore the prevalence of self-reported diagnoses of cancer in the last 5 years among sexual minorities compared with heterosexual women and men. We analyzed data from 249,010 hospital-based English Cancer Patient Experience Survey responders with sexual orientation as a binary outcome, and International Classification of Diseases, Tenth, Revision, diagnosis as covariate—38 different common and rarer cancers, with breast and prostate cancer as baseline categories for women and men, respectively—to examine whether people from sexual minorities are over- or under-represented among different cancer sites. For both analyses, we used logistic regression, stratified by sex and adjusted for age. Results A diagnosis of cancer in the past 5 years was more commonly reported by male General Practice Patient Survey responders who endorsed gay or bisexual orientation compared with heterosexual men (odds ratio [OR], 1.31; 95% CI, 1.15 to 1.49; P < .001) without evidence of a difference between lesbian or bisexual compared with heterosexual women (OR, 1.14; 95% CI, 0.94 to 1.37; P = .19). For most common and rarer cancer sites (30 of 33 in women, 28 of 32 in men), the odds of specific cancer site diagnosis among Cancer Patient Experience Survey respondents seemed to be independent of sexual orientation; however, there were notable differences in infection-related (HIV and human papillomavirus [HPV]) cancers. Gay or bisexual men were over-represented among men with Kaposi’s sarcoma (OR, 48.2; 95% CI, 22.0 to 105.6), anal (OR, 15.5; 95% CI, 11.0 to 21.9), and penile cancer (OR, 1.8; 95% CI, 0.9 to 3.7). Lesbian or bisexual women were over-represented among women with oropharyngeal cancer (OR, 3.2; 95% CI, 1.7 to 6.0). Conclusion Large-scale evidence indicates that the distribution of cancer sites does not vary substantially by sexual orientation, with the exception of some HPV- and HIV-associated cancers. These findings highlight the importance of HPV vaccination in heterosexual and sexual minority populations.
Persuasion: A Case Study of Papal Influences on Fertility-Related Beliefs and Behavior
Authors: Bassi Vittorio , Rasul Imran 
Published: September 2017

We study the persuasive impacts of non-informative communication on the short-run beliefs and long-run behavior of individuals. We do so in the context of the Papal visit to Brazil in October 1991, in which persuasive messages related to fertility were salient in Papal speeches during the visit. We use individual's exposure to such messages to measure how persuasion shifts short-run beliefs such as intentions to contracept and long-term fertility outcomes such as the timing and total number of births. To measure the short-run causal impact of persuasion, we exploit the fact the Brazil 1991 DHS was fielded in the weeks before, during, and after the Papal visit. We use this fortuitous timing to identify that persuasion significantly reduced individual intentions to contracept by more than 40 percent relative to pre-visit levels, and increased the frequency of unprotected sex by 30 percent. We measure the long-run causal impacts of persuasion on fertility outcomes using later DHS surveys to conduct an event study analysis on births in a five-year window on either side of the 1991 Papal visit. Estimating a hazard model of fertility, we find a significant change in births 9 months post-visit, corresponding to a 1.6 percent increase in the aggregate birth cohort. Our final set of results examine the very long-run impact of persuasion and document the impacts to be on the timing of births rather than on total fertility. (JEL D83, J13, N36)
Case Report: Inflammatory myofibroblastic tumor causes formation of an ileal conglomerate in a patient previously treated for Wilms’ tumor
Authors: Leganger Julie , Raagaard Soerensen Rikke , Rosenberg Jacob , Burcharth Jakob 
Published: September 2017

Introduction: Inflammatory myofibroblastic tumors (IMTs) are uncommon mesenchymal lesions classified by WHO as neoplasms of uncertain behavior. Morphologically, IMTs are composed of proliferating spindled myofibroblastic cells accompanied by a marked - usually chronic - inflammatory infiltrate. The etiology is unknown, but several theories have been suggested, including an association with Wilms’ tumor. IMTs are rarely diagnosed in adults and have been reported in various organs. IMTs are considered benign but with a potential to recur at their primary site. Case report: A 44-year-old female experienced intermittent severe abdominal pain, loose stools and a visible abdominal bulge. In early childhood the patient had been treated for a Wilms’ tumor. At admission Meckel’s diverticulitis was suspected, but during surgery a tumor in the terminal ileum, creating a conglomerate of small intestinal loops, was observed and completely resected. The pathology report characterized the tumor as a histologically benign inflammatory myofibroblastic tumor. Postoperatively, the patient experienced several complications including an anastomotic leakage and subsequent formation of an abscess and transcutaneous fistula. Discussion: IMTs rarely arise in the small intestine, and to our knowledge the manifestation of a small intestine conglomerate has not been described previously. Making the diagnosis is difficult, and numerous differential diagnoses were possible in this case. Approximately 8-25% of IMTs in the gastrointestinal tract recur locally. Complete surgical resection is the treatment of choice, and re-excision is the preferred therapy for local recurrence. To our knowledge, no guidelines concerning follow-ups are available. Conclusion: IMTs in the terminal ileum can mimic Meckel’s diverticulitis and present with symptoms of obstructive ileus due to the formation of a conglomerate of small intestinal loops. Furthermore, IMTs should be considered as a diagnostic possibility in patients with a past medical history of Wilms’ tumor.
The evaluation of a virtual education system based on the DeLone and McLean model: A path analysis
Authors: Mahmoodi Zohreh , Esmaelzadeh- Saeieh Sara , Lotfi Razieh , Baradaran Eftekhari Monir , Akbari Kamrani Mahnaz , Mehdizadeh Tourzani Zahra , Salehi Katayoun 
Published: September 2017

Background: The Internet has dramatically influenced the introduction of virtual education. Virtual education is a term that involves online education and e-learning. This study was conducted to evaluate a virtual education system based on the DeLone and McLean model. Methods: This descriptive analytical study was conducted using the census method on all the students of the Nursing and Midwifery Department of Alborz University of Medical Sciences who had taken at least one online course in 2016-2017. Data were collected using a researcher-made questionnaire based on the DeLone and McLean model in six domains and then analyzed in SPSS-16 and LISREL-8.8 using the path analysis. Results: The goodness of fit indices (GFI) of the model represent the desirability and good fit of the model, and the rational nature of the adjusted relationships between the variables based on a conceptual model (GFI = 0.98; RMSEA = 0.014).The results showed that system quality has the greatest impact on the net benefits of the system through both direct and indirect paths (β=0.52), service quality through the indirect path (β=0.03) and user satisfaction through the direct path (β=0.73). Conclusions: According to the results, system quality has the greatest overall impact on the net benefits of the system, both directly and indirectly by affecting user satisfaction and the intention to use. System quality should therefore be further emphasized, to use these systems more efficiently.
The Contingent Wisdom of Dyads: When Discussion Enhances vs. Undermines the Accuracy of Collaborative Judgments
Authors: Minson Julia A. , Mueller Jennifer S. , Larrick Richard P. 
Published: September 2017

We evaluate the effect of discussion on the accuracy of collaborative judgments. In contrast to prior research, we show that discussion can either aid or impede accuracy relative to the averaging of collaborators’ independent judgments, as a systematic function of task type and interaction process. For estimation tasks with a wide range of potential estimates, discussion aided accuracy by helping participants prevent and eliminate egregious errors. For estimation tasks with a naturally bounded range, discussion following independent estimates performed on par with averaging. Importantly, if participants did not first make independent estimates, discussion greatly harmed accuracy by limiting the range of considered estimates, independent of task type. Our research shows that discussion can be a powerful tool for error reduction, but only when appropriately structured: Decision makers should form independent judgments to consider a wide range of possible answers, and then use discussion to eliminate extremely large errors.Data and the online appendix are available at https://doi.org/10.1287/mnsc.2017.2823 .This paper was accepted by Yuval Rottenstreich, judgment and decision making.