bluuebunny/crossref_metadata_2025_split huggingface dataset:
A synergic approach using the model and remote sensing data for flood monitoring in under-observed transboundary rivers
Authors: Lamichhane Suraj , Karki Nischal , Pandey Vishnu Prasad , Joshi Pradhumna , Dawadi Sarita 
Published: September 2024

ABSTRACT
The southern plain of Nepal recognized as the ‘granary of Nepal’, confronts recurrent monsoon-induced flooding, posing a substantial threat to its pivotal role as a major agricultural contributor to the national economy. As an analysis, this study employs advanced satellite imagery to delineate historical floods in nine flood-prone transboundary basins and compares the rainfall-induced model-based inundation in the West Rapti Basin (WRB) to validate the result. The extent of flooding was mapped between 2015 and 2022 using Sentinel-1 Synthetic Aperture Radar data processed on Google Earth Engine. Hydrodynamic modelling centred on the WRB, incorporated daily measured precipitation data with varying return periods over a 10 m resolution digital elevation model generated through an in situ survey. The model was calibrated for the August 2017 flood event with Nash–Sutcliffe efficiency greater than 70% and validation reasonably with satellite-derived flood maps with Cohen's Kappa value of 0.58 and an overall accuracy metric of 0.84. This synergic approach integrates climatology, remote sensing data, and hydraulics to monitor transboundary river floods in Nepal where precise hydro-meteorological data are limited, thus, offering continuous all-weather monitoring.
Utilization of waste hot air of medical oxygen plant in solar desalination unit employing jet impingement air heater for water production
Authors: Sachdev Taranjeet , Thakur Aditya 
Published: September 2024

ABSTRACT

Many oxygen plants have been established specially during COVID-19 period and they are still serving for medical needs. The objective of the present work is to utilize solar and waste thermal energy of medical oxygen plants for water production. Humidification–dehumidification desalination (HDD) has been found suitable for this objective due to low temperature energy need during the process. The layout of an HDD unit has been presented to utilize waste heat, specially when solar energy is not much effective or absent. The system has been configured with a jet impingement solar air heater and a packed bed humidifier. A mathematical model has been developed and validated with the results of experiments. A comparative study of the proposed unit (HDD-O2) and a conventional unit has been performed in terms of yield and gained output ratio (GOR). The optimum flow rates of working fluids found in the range 0.03–0.04 kg/s and the temperature of air and water resulted in a continuous gain in yield. The average yield and GOR of the HDD-O2 unit were found to be 8.5 kg/d and 1.1 that could reach up to 11 kg/d and 1.4, respectively. The HDD-O2 unit provided yield at the cost of 0.04 $/kg with a payback period of 1.73 years. The findings of the present work indicated the suitability of the HDD-O2 plant for water production.
Research, Development and Pharmacological Activity of Sinomenine and Its Derivatives
Authors: Zong Tieqiang , Sun Jinfeng , Hu Zhengyu , Jin Long , Cui Lantian , Xue Yongkang , Zhou Wei , Li Gao 
Published: September 2024

Abstract:
In this manuscript, the resource distribution, pharmacological activity, pharma-cokinetics of sinomenine and the structure, synthesis, biological activity and mechanism of sinomenine derivatives reported from 2000 to December 2023 were reviewed. The lit-erature was retrieved through Web of Science, PubMed, Science Direct, SciFiner Scholar and other websites. Sinomenine belongs to isoquinoline alkaloids and was extracted from the Chinese herb Sinomenium acutum root. In Asian countries such as China and Japan, it is commonly prescribed as a treatment for rheumatoid arthritis. In addition, sinomenine also has sedative, analgesic, anti-inflammatory, immunosuppressive, neuroprotective, an-ti-drug dependence, anti-tumor and other biological activities. Sinomenine limited its ap-plication prospects because of its large dosage, poor epidermal permeability and short half-life. To overcome these defects, new sinomenine derivatives have been synthesized. Based on the comprehensive analysis of relevant literature at home and abroad, this paper reviews the recent progress in the study of sinomenine's pharmacological effects and structural modifications. Future research on sinomenine will focus on improving its thera-peutic effect, and developing new drug preparations and structural modifications. It is hoped that this review will help to better understand the research progress of sinomenine and provide constructive suggestions for further research of sinomenine.
Structural Insight into Wild Type of Arginine Deiminase Protein and its Three Mutated Versions in Complex with Arginine Molecule: A Computational Approach
Authors: Abdollahi Sara , Eslami Mahboobeh , Morowvat Mohammad Hossein , Ghasemi Younes 
Published: September 2024

Aims:
This study aims to analyze the wild type of arginine deiminase and three mutant
forms of it (G320L, A303R, and E304L) in complex with arginine molecule using Molecular Dynamics
(MD) simulation to find the best enzyme form with a lower level of energy and more stability.

Background:
Arginine Deiminase (ADI) is an arginine-degrading enzyme that has an anticancer
effect on some cancers, such as Hepatocellular Carcinoma (HCC) and melanoma.

Methods:
Homology models of native and mutant forms of ADI were generated and evaluated using
the I-TASSER and other databases and prediction algorithms. All prepared enzyme structures
via homology modeling were used as receptors in the molecular docking and MD simulation
steps.

Results:
MD simulation results demonstrated that the G302L structure has the lowest value of Rg
over MD simulation time, indicating its more appropriate intramolecular interactions than other
structures. G302L has also established the most desirable interactions with arginine molecules during
80 ns MD simulation so that the G302L/ arginine complex has the maximum intermolecular
hydrogen bonds. Arginine molecule in complex with G302L has the best position in the active site
of ADI protein.

Conclusion:
The G302L mutant ADI from Mycoplasma hominis can be a good candidate for better
stability in arginine deprivation therapy in arginine auxotrophic cancers.
Long-term Safety Monitoring and Efficacy Status of Infliximab and its Biosimilars in Psoriasis Management
Authors: Sharma Kiran , Ghai Roma , Rana Neha 
Published: September 2024

Abstract:
Infliximab (INF), a murine human monoclonal antibody, is a substantially more successful
biologic than topical drugs for treating mild to severe psoriasis because it clears the skin
rapidly due to its fast onset of action. Loss of responsiveness over time and some adverse effects,
especially the experience of infusion reactions, are the major causes of non-compliance with INF
medication. Therefore, evaluation of the long-term reliability of anti-tumor necrosis factor (TNF)
medications is necessary for the assessment of the risks associated with long-term anti-TNF therapy.
For psoriasis, there are registered safety statistics; however, these individuals might not receive
the same level of care as those in a randomized study. Few assessments of the safety of anti-
TNF medications across indications, including their biosimilars, are present, but it’s still unknown
how anti-infliximab antibodies arise and produce harmful effects. INF biosimilars, when
subjected to human studies to reduce cost and improve access, provide therapeutic benefits with
associated adverse events, showing variations in incidence depending upon varying patient populations
and no new safety indications. During therapy, certain individuals develop antibodies
against INF, which are believed to be linked to a loss of response (LOR). Additional research
aimed at identifying individuals who are susceptible to treatment resistance is likely to assist
doctors in accurately selecting the appropriate candidates for anti-TNF-α therapy and enhancing
the long-term effectiveness of the treatment. From clinical studies, we expect to learn about how
to utilize INF or its biosimilars more effectively in the management of psoriasis. Therefore, the
paper focuses on the efficacy and safety monitoring of INF and developed biological therapies.
From Crisis to Catalyst: How COVID-19 Helped Humanity to Come Back Stronger Against the Pandemic
Authors: Gupta Shibaji , Aikat Aditi 
Published: September 2024

Background:
The COVID-19 pandemic has brought unprecedented human suffering but
has taught the human race several lessons on survival as well.

Aim:
In this narrative review, we discuss how humanity implemented the lessons it learned from the
pandemic to ultimately win over it.

Methods:
Literature with documented evidence-based findings was searched using ‘Litcovid’ and
Google Scholar databases using keywords such as ‘positive lessons,’ ‘learnings,’ ‘beneficial effects,’
and ‘COVID-19 pandemic’. Relevant peer-reviewed human studies published between 2020 and
June 2023 were included, along with pertinent reports from newspapers and global health bodies.

Conclusion:
The world experienced immense suffering during the COVID-19 pandemic. However,
while the pandemic has left indelible marks in terms of emptying the glass of life, somewhere, as
evident, it has also helped fill it up in a never-before manner.

Results:
The pandemic has spurred technological progress, heightened public health awareness, and
increased investment in public health infrastructure, surveillance, and research. International collaboration
to meet global needs has been strengthened. Public health and healthcare workers' roles were
redefined, emphasising health as an investment. This pandemic has presented new perspectives for
healthcare research. Greenhouse gas emissions have decreased, and green energy has been promoted.
Lockdowns have allowed nature to recover, giving wildlife the opportunity to repopulate. Improved
air and water quality, better work-life balance, and increased self-growth have led to paradoxical
improvements in lifestyle disorders. Interpersonal and intersectoral collaboration was valued more,
and food security, reduced crime rates, and increased self-reliance were observed.
Inovação e território no Brasil: o perfil urbano-regional da subvenção econômica à inovação entre 2010-2019
Authors: Costa Aldenilson 
Published: September 2024

O papel da inovação no território justifica as estratégias implementadas para estimular a atividade inovadora, sobretudo a partir de investimentos públicos. Nosso objetivo é analisar o perfil urbano-regional dos projetos de subvenção econômica à inovação contratados pela Financiadora de Estudos e Projetos (Finep) entre 2010 e 2019. O resultado obtido através de estatística descritiva destaca a distribuição desigual das empresas contempladas no conjunto do território, reforçando a concentração das empresas situadas em cidades médias e metrópoles das regiões Sul e Sudeste. Evidencia ainda a fragilidade das estratégias governamentais incapazes de romper com esse perfil espacial.
Harmonisasi Manusia dengan Alam dan Ekologi: Kajian atas Budaya Tamping di Masyarakat Tengger
Authors: Sukmawan Sony , Alifah Nurul 
Published: September 2024

Masyarakat Tengger mengenal tiga relasi kosmologi, yaitu prahyangan, pawongan, dan palemahan, yakni tiga sumber kebahagiaan dan keharmonisan dalam hidup, berupa relasi manusia dengan Tuhan, sesama manusia, dan manusia dengan alam. Tamping hadir sebagai manifestasi dari harmonisasi masyarakat Tengger dengan alam. Tamping merupakan sesaji yang digunakan masyarakat Tengger dalam banyak momentum sakral, termasuk dalam tradisi pujan Tengger. Terdiri juadah, bra-kulup, gedhang ayu, pipis-pasung, tetel, nasi, dan lauk pauk yang dibungkus dengan daun pisang, setiap bagian tamping menyiratkan makna dimensi ekologis yang tercermin dalam keyakinan, pemikiran, ucapan, dan perilaku positif masyarakat Tengger terhadap alam. Penelitian ini menggunakan paradigma kualitatif dengan perspektif penelitian lapangan. Hasil penelitian menunjukkan bahwa bahan pembuatan Tamping dan komponen-komponennya merupakan simbolisasi keharmonisan masyarakat Tengger dengan alam. Hal ini mempunyai dampak yang signifikan terhadap ekologi. Dampak ekologis tersebut diwujudkan dalam cara pandang, kepercayaan, dan perilaku positif masyarakat Tengger terhadap ladang, air, tanah, tumbuhan, dan pepohonan.
Penggunaan Video On Demand (VOD) Brand Netflix Sebagai Media Hiburan Alternatif Selama Pandemi 2020
Authors: Mardhiyyah Mardhiyyah 
Published: September 2024

Pandemi Covid-19 memang membawa perubahan yang sangat signifikan disegala aspek kehidupan masyarakat. Tidak hanya dalam aspek ekonomi, aspek kesehatan, aspek politik, aspek sosial, hingga merubah gaya hidup masyarakat. Gaya hidup yang paling banyak berubah adalah cara berinteraksi dan mobilisasi masyarakat yang harus melakukan semua kegiatan sehari-hari di rumah. Akibatnya, terjadi kejenuhan tinggi yang menyebabkan masyarakat mulai mencari media-media hiburan alternatif untuk menghindari kejenuhan di rumah.Selain memanfaatkan media elektronik seperti televisi dan radio ataupun media komunikasi seperti smartphone, saat ini masyarakat Indonesia sedang marak menggunakan Video on Demand (VoD) sebagai media hiburan alternatif untuk menghilangkan kejenuhan beraktivitas di rumah. Salah satu VoD yang sangat populer saat ini di Indonesia adalah Netflix.Peneliti menilai bahwa perlu adanya penelitian yang menggambarkan penggunaan Video on Demand (VoD) Neflix ini sebagai media hiburan alternatif selama pandemi 2020. Metode penelitian yang digunakan adalah studi kasus dengan pendekatan Kualitatif. Adapun yang menjadi subjek penelitian ini adalah pengguna aktif Netflix yang menjadikan Netfliz sebagai media hiburan alternatif selama Pandemi. Hasil dari penelitian ini diharapkan dapat dipublikasikan dalam jurnal nasional terakreditasi Sinta 5, yaitu Jurnal Visi Komunikasi. Sebagai penelitian dasar, maka penelitian ini dapat dikategorikan dalam tingkat kesiapterapan teknologi (TKT) level 3, yaitu sebagai pembuktian konsep fungsi dan/atau karakteristik penting secara analitis dan eksperimental.Hasil penelitian ini menunjukkan Preferensi khalayak pada konten media digital dibanding konten yang disajikan oleh media konvensional dikarenakan adanya kemudahaan dan nilai efisien yang ditawarkan oleh media digital sehingga khalayak dapat menikmati konten siaran dimanapun dan kapanpun walaupun hanya dengan menggunakan smartphone, varian siaran yang terbatas dan monoton, serta kualitas isi siaran yang kurang kreatif dan tidak lagi mendidik masyarakat untuk menjadi penonton yang cerdas.
Participatory Environmental Governance and Payments for Environmental Services: the Strategic Role of Universities
Authors: Prado Ana Cristina Campos , Novaes André Lucas , Cardoso Giselle Cristina , Zaro Elise Soerger , Tiezzi Rafael de Oliveira 
Published: September 2024

Objective: The objective of this study is to investigate the integration of Participatory Environmental Governance into Payment for Environmental Services (PES) programs, with the aim of proposing a theoretical model that actively involves universities as facilitators in this process.

Theoretical Framework: The theories of Participatory Environmental Governance and the Payment for Environmental Services model are highlighted, providing a solid foundation for understanding the research context.

Method: A theoretical and qualitative approach is used. The study involves a review of existing literature on PES and Participatory Governance, followed by a discussion of the limitations of current models and the proposal of a new framework for the proposed integration.

Results and Discussion: The results revealed the potential effectiveness of Participatory Environmental Governance in improving the equity and sustainability of PES programs. The relationships between community participation, universities, and the success of PES are highlighted.

Research Implications: The implications of this research can be applied to public policies and environmental management practices. These implications may encompass areas such as environmental education, conservation policies, and the role of universities in sustainability.

Originality/Value: This study contributes to the literature by proposing a novel integration between Participatory Environmental Governance and PES programs, highlighting the strategic role of universities. The relevance and value of this research are evidenced by its potential application in different contexts, promoting more participatory and sustainable natural resource management.
Production Costs in the Processing of Cocoa Derivatives
Authors: García Ketty del Rocío Hurtado , Briones Rosa Marjorie Torres , Sinchiguano Brenda Elizabeth Oña , Cano Gloria Evelina Pazmiño , Marmolejo Fabián Medardo Moran 
Published: September 2024

Objective: The objective of this study is to determine the costs generated in the production of cocoa derivatives through a production order costing system in the Asociación de Producción Agrícola de Cacao Nacional La Maná (ASOPROCANAM).

Theoretical Framework: The main concepts on production costs and cocoa derivatives in ASOPROCANAM are presented, which allow understanding the research.

Method: The adopted methodology of research with a mixed approach, qualitative-quantitative, supported by a documentary bibliographic research, among the research techniques were the interview applied to the owner and the observation at the site where the company is located to determine the processes that were carried out in the elaboration of cocoa derivatives. The instruments were the interview questionnaire and the matrix of cost elements.

Results and Discussion: It is concluded that the design of a production order costing system allowed an effective management of production costs in the production of cocoa derivatives such as chocolate bars, chocolates and hydration drinks, this system provides a structured approach to allocate costs to each production order and a net profit of 31%, which translates into $0.70 cents for each hydration drink sold.

Implications of the research: The production processes, as well as the cost elements used in the elaboration of the cocoa products, thus the chocolate bars, the total costs were $238.75, having a total unit cost of $0. 24 cents, an operating profit of 52% and a net profit of 33%, which translates into $0.17 cents for each chocolate bar sold; for chocolates, total costs were $206.67, with a total unit cost of $0.07 cents, an operating profit of 70% and a net profit of 45%.
Preparation of a Map of Potential Areas For the Installation of a Sewage Treatment Plant in the Porto Murtinho/MS Region
Authors: Corrêa Nelison Ferreira , Paranhos Filho Antonio Conceição , Ribeiro Vinícius de Oliveira , Martins Valmor Nazario , Oliveira Bruna Alves de Souza , Oliveira Junior Elias de 
Published: September 2024

Objective: The main objective is to prepare a thematic map to identify potential areas for the installation of a Sewage Treatment Station (ETE).

Theoretical Framework: This study addresses the importance of selecting locations for the installation of ETEs, which prioritize environmental and social aspects, in which geotechnologies are presented as valuable tools for efficient and integrated analysis.

Method: The methodology of this research was based on the acquisition and processing of geospatial and environmental data, complemented by the generation of thematic maps such as watercourses, areas subject to flooding, roads, land use and occupation, slope, soils and distances from the urban perimeter. Data integration through map algebra was performed in the QGIS software, in addition, WRPLOT View was used for the directional analysis of the winds in Porto Murtinho/MS.

Results and Discussion: The results of this study indicate that the areas with the greatest potential for installation are mostly located within 1 (one) kilometer of the urban perimeter security strip. The analysis of the prevailing winds revealed that they form a corridor in the north/south direction, suggesting that the regions east of the city are more suitable for the implementation of the treatment system.

Research Implications: The multifaceted approach, considering environmental and operational factors, makes it possible to identify suitable areas for ETEs.

Originality/Value: This study was developed, highlighting that limiting factors are essential in identifying areas unsuitable for installing the structure, while non-limiting maps are essential for classifying the installation potential.
Additive Manufacturing of Waste Electrical and Electronic Equipment (WEEE) Produced From Acrylonitrile Butadiene Styrene (ABS)
Authors: Simon Douglas Alexandre , Mantovani Jonas , Bischoff Eveline 
Published: September 2024

Objective: To evaluate the feasibility of producing recycled acrylonitrile-butadiene-styrene (r-ABS) filaments from waste electrical and electronic equipment (W EEE) casings, specifically discarded monitors and televisions, and to compare their properties with those of virgin ABS.

Theoretical Framework: The research was based on a literature review of additive manufacturing, WEEE recycling, and the thermal, mechanical, rheological, and microscopic characterizations of recycled polymers, with an emphasis on fused deposition modeling (FDM).

Method: WEEE casings were collected and mechanically recycled to produce r-ABS filaments. These filaments were characterized and compared with virgin ABS filaments using infrared spectroscopy (FTIR), thermal analyses (TGA and DSC), rheological, mechanical, and microscopic evaluations.

Results and Conclusion: The results indicated that r-ABS filaments exhibit properties comparable to those of virgin ABS. FTIR analysis revealed the presence of the main functional groups of ABS in the recycled samples. Thermal analysis showed similar behavior between the recycled and virgin materials, with a single thermal decomposition event. Rheological analysis demonstrated that r-ABS possesses viscoelastic properties suitable for the FDM process, and mechanical characterization showed that r-ABS exhibited tensile strength close to virgin ABS. Microscopic analysis revealed good layer adhesion and a low number of voids, factors that contribute to the quality of the printed objects.

Research Implications: This study contributes to the valorization of polymeric waste, promoting the use of recycled materials in additive manufacturing processes, which can benefit both the environment and the 3D printing industry.

Originality/Value: The research addresses a topic still underexplored in the literature, especially concerning the recycling of WEEE casings for the production of ABS filaments.