bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Policy Uncertainty on Macro Variables – An SVAR-Based Empirical Analysis for EU Countries
Authors: Kronen Dominik , Belke Ansgar 
Published: September 2017

AbstractIn light of the rising political and economic uncertainty in Europe, we aim to provide a basic understanding of the impact of policy and stock market uncertainty on a set of macroeconomic variables such as production and investment. In this paper, we apply a structural vector autoregressive (SVAR) model to gain first insights that may help to identify avenues for further research. We find that stock market volatility shows a fairly consistently negative effect. However, the implications of policy uncertainty for Europe and the euro area in particular are not so straightforward.
Scholarship and Language Revival: Language Ideologies in Corpus Development for Revived Manx
Authors: Lewin Christopher 
Published: September 2017

AbstractIn this article the role of different ideological viewpoints concerning corpus development within the Manx revival movement in the second half of the twentieth century is explored. In particular, the work of two prominent figures is examined: the Celtic scholar Robert L. Thomson, who published extensively especially on Manx language and literature, and also contributed to the revival, particularly as editor of several pedagogical resources and as a member of the translation committee Coonceil ny Gaelgey, and Douglas Fargher, a tireless activist and compiler of an English-Manx Dictionary (1979). Broadly speaking, Thomson was of a more preservationist bent, cautious in adapting the native resources of the language and wary of straying too far from attested usage of the traditional language, while Fargher was more radical and open especially to borrowing from Irish and Scottish sources. Both were concerned, in somewhat different ways, to remove perceived impurities or corruptions from the language, and were influenced by the assumptions of existing scholarship. A close reading of the work of these scholar-activists sheds light on the tensions within the revival movement regarding its response to the trauma of language death and the questions of legitimacy and authenticity in the revived variety. Particular space is devoted to an analysis of the preface of Fargher’s dictionary, as well as certain features of the body of the work itself, since this volume is probably the most widely consulted guide to the use of the language today. Finally, it is argued that the Manx language movement today would benefit from a reassessment and discussion of the ideological currents of the past and present, and a judicious evaluation of both the strengths and weaknesses of existing reference works.
La place du sujet dans la sémiotique de Greimas
Authors: Moreno Luisa Ruiz 
Published: September 2017

Résumé
La réflexion sémiotique sur le sujet est issue de la philosophie et de la logique, qui semblent se réunir dans la grammaire quand cette dernière se penche justement sur le sujet. Quant à la sémiotique, science qui élabore sa propre grammaire à partir de conceptions philosophiques et logiques, sans pour autant y trouver un lien satisfaisant, la question du sujet est toujours à un stade de résolution conflictuelle : le sujet est l’un des termes d’une relation actantielle, sujet-objet. La relation, non le sujet, est la source surdéterminante. Le sujet, quant à lui, est aussi le protagoniste, au même titre que l’autre terme, à savoir l’objet. Cette mise à niveau des termes privilégiant la fonction actantielle a donné naissance à l’idée que la sémiotique ne s’occupe pas du sujet ou bien qu’elle a une première étape objectale et une seconde étape subjectale. Le résultat provisoire de cette discussion est que le sujet s’est diversifié par rapport aux différents actants qui se conforment dans la fonction directrice. Nous chercherons la source greimassienne de la conception du sujet qui a donné lieu à cette problématique actuelle.
Analysis of Risk Factors for Development of Cognitive Disorders in Maintenance Hemodialysis Patients - Pilot Study
Authors: Jovanovic Milena , Todorovic Zeljko , Milovanovic Dragan , Draskovic Branislava , Todorovic Andreja , Petrovic Dejan 
Published: September 2017

Abstract
Prevalence of cognitive disorders is high in maintenance hemodialysis patients. Montreal cognitive assessment (MoCA) is used for detecting and evaluation of cognitive disorder degree in this patient population. In examined patient population, only 5 (12.5%) of them had normal cognitive function (MoCA ≥26). Mild cognitive impairment (MoCA 18-26) was found in 65.9% (29) patients, while moderate cognitive disorder (MoCA 10-17) was detected in 6 (21.6%) patients. Major cognitive disorder wasn’t detected in examined population. Statistically signifi cant correlation was not established between laboratory parameters and overall MoCA score. Statistically signifi cant correlation, however, was established between MoCA item that evaluates space and time orientation and intermediate secondary hyperparathyroidism and space and time orientation and severe secondary hyperparathyroidism. Hemodynamic instability during hemodialysis and silent ischemia of the brain are increasing risk of appearance of cognitive disorders in maintenance hemodialysis patients.
“Hard to Beat Dickens’ Characters”: Non-Canonical Syntax in Evaluative Texts
Authors: Pham Teresa 
Published: September 2017

AbstractThe present paper focuses on non-canonical syntactic constructions in the language of evaluation. It explores in which ways and under which conditions certain syntactic constructions deviating from the unmarked SVX pattern can support the expression of the writer’s/speaker’s attitude. The study is based on a corpus of academic and non-academic book reviews (published online and in print in scientific journals of different disciplines and on the cataloguing websiteGoodreadsrespectively). It-extrapositions, existentialtheresentences, andwh-clefts contained in the corpus were analysed not only as to the evaluations expressed within them but also as to other parameters, including the occurrence of different forms of evaluation, the mention of specific sources or participating roles of evaluation as well as information structure.
Typological Interference in Information Structure: The Case of Topicalization in Asia
Authors: Leuckert Sven 
Published: September 2017

AbstractTopicalization refers to the sentence-initial placement of constituents other than the subject and is often listed as a non-canonical construction [cf. Ward, Gregory, Betty J. Birner and Rodney Huddleston (2002). “Information Packaging.” Rodney Huddleston and Geoffrey K. Pullum, eds.The Cambridge Grammar of the English Language. Cambridge: Cambridge University Press, 1363–1447.]. In this paper, tokens of topicalization in the direct conversations in theInternational Corpus of Englishfor Hong Kong and India and, for comparison, Great Britain are analysed. In order to find out if topicalization is a contact-induced feature, typological profiles with regard to topic-prominence [Li, Charles N. and Sandra A. Thompson (1976). “Subject and Topic: A New Typology of Language.” Charles N. Li, ed.Subject and Topic. New York: Academic Press, 457–489.] are created for three Indo-Aryan, three Dravidian and two Sinitic languages. I suggest that the low frequencies of topicalization in Hong Kong English and the high frequencies of topicalization in Indian English are primarily due to differences in intensity of contact [Thomason, Sarah G. (2001).Language Contact. Washington, D.C.: Georgetown University Press.] and variety development [Schneider, Edgar W. (2007).Postcolonial English. Varieties Around the World. Cambridge: Cambridge University Press.]. Typological interference at the level of information structure is assumed to only come to the fore in further developed varieties and after prolonged contact.
Shoulda, Coulda, Woulda – Non-Canonical Forms on the Move?
Authors: Freudinger Markus 
Published: September 2017

Abstract
In this paper, the contractions shoulda, coulda, woulda are compared with their respective full forms should have, would have, and could have. Although the full forms are used much more frequently and are, therefore, considered canonical, the non-canonical forms have increased in frequency throughout the better part of the twentieth century. They are predominantly used in American English – in conversation as well as in fictional writing to imitate speech. With respect to their syntactic environment, shoulda, coulda, and woulda behave differently than their full counterparts since they are often used without subjects and without lexical verbs. Some of these uses can be explained by the fact that shoulda, coulda, and woulda are not always used as verbal items but also as nouns, adjectives, and interjections. Due to their overall low frequency and their restriction to a particular register, however, it appears they will keep their non-canonical status for the foreseeable future.
Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons Identified Through Single-Cell Gene Expression Analysis
Authors: Mickelsen Laura E. , Kolling Fredrick W. , Chimileski Brock R. , Fujita Akie , Norris Carol , Chen Kun , Nelson Craig E. , Jackson Alexander C. 
Published: September 2017

AbstractThe lateral hypothalamic area (LHA) lies at the intersection of multiple neural and humoral systems and orchestrates fundamental aspects of behavior. Two neuronal cell types found in the LHA are defined by their expression of hypocretin/orexin (Hcrt/Ox) and melanin-concentrating hormone (MCH) and are both important regulators of arousal, feeding, and metabolism. Conflicting evidence suggests that these cell populations have a more complex signaling repertoire than previously appreciated, particularly in regard to their coexpression of other neuropeptides and the machinery for the synthesis and release of GABA and glutamate. Here, we undertook a single-cell expression profiling approach to decipher the neurochemical phenotype, and heterogeneity therein, of Hcrt/Ox and MCH neurons. In transgenic mouse lines, we used single-cell quantitative polymerase chain reaction (qPCR) to quantify the expression of 48 key genes, which include neuropeptides, fast neurotransmitter components, and other key markers, which revealed unexpected neurochemical diversity. We found that single MCH and Hcrt/Ox neurons express transcripts for multiple neuropeptides and markers of both excitatory and inhibitory fast neurotransmission. Virtually all MCH and approximately half of the Hcrt/Ox neurons sampled express both the machinery for glutamate release and GABA synthesis in the absence of a vesicular GABA release pathway. Furthermore, we found that this profile is characteristic of a subpopulation of LHA glutamatergic neurons but contrasts with a broad population of LHA GABAergic neurons. Identifying the neurochemical diversity of Hcrt/Ox and MCH neurons will further our understanding of how these populations modulate postsynaptic excitability through multiple signaling mechanisms and coordinate diverse behavioral outputs.
Spontaneous Eye Blink Rate (EBR) Is Uncorrelated with Dopamine D2 Receptor Availability and Unmodulated by Dopamine Agonism in Healthy Adults
Authors: Dang Linh C. , Samanez-Larkin Gregory R. , Castrellon Jaime J. , Perkins Scott F. , Cowan Ronald L. , Newhouse Paul A. , Zald David H. 
Published: September 2017

AbstractSpontaneous eye blink rate (EBR) has been proposed as a noninvasive, inexpensive marker of dopamine functioning. Support for a relation between EBR and dopamine function comes from observations that EBR is altered in populations with dopamine dysfunction and EBR changes under a dopaminergic manipulation. However, the evidence across the literature is inconsistent and incomplete. A direct correlation between EBR and dopamine function has so far been observed only in nonhuman animals. Given significant interest in using EBR as a proxy for dopamine function, this study aimed to verify a direct association in healthy, human adults. Here we measured EBR in healthy human subjects whose dopamine D2 receptor (DRD2) availability was assessed with positron emission tomography (PET)-[18F]fallypride to examine the predictive power of EBR for DRD2 availability. Effects of the dopamine agonist bromocriptine on EBR also were examined to determine the responsiveness of EBR to dopaminergic stimulation and, in light of the hypothesized inverted-U profile of dopamine effects, the role of DRD2 availability in EBR responsivity to bromocriptine. Results from 20 subjects (age 33.6 ± 7.6 years, 9F) showed no relation between EBR and DRD2 availability. EBR also was not responsive to dopaminergic stimulation by bromocriptine, and individual differences in DRD2 availability did not modulate EBR responsivity to bromocriptine. Given that EBR is hypothesized to be particularly sensitive to DRD2 function, these findings suggest caution in using EBR as a proxy for dopamine function in healthy humans.
Of Mice and Men: Empirical Support for the Population-Based Social Epistasis Amplification Model (a Comment on )
Authors: Sarraf Matthew Alexandar , Woodley of Menie Michael Anthony 
Published: September 2017

AbstractThis commentary article offers new perspective on recent research investigating the behavioral and social ecological effects of a mutation related to autism spectrum disorders in mice. The authors explain the consistency of this research on mice with predictions advanced by a theory of the role of mutations in altering interorganismal gene-gene interactions (social epistasis) in social species including humans, known as the social epistasis amplification model. The potential significance of the mouse research for understanding contemporary human behavioral trends is explored.
Solucionando dificultades en el aula: una estrategia usando el aprendizaje basado en problemas
Authors: Valderrama Sanabria Mery Luz , Castaño Riobueno Gerardo Alberto 
Published: September 2017

Introducción: Se utiliza el proyecto de investigación en el aula con énfasis en el Aprendizaje Basado en Problemas, el cual promueve el aprendizaje activo y significativo, permitiendo solucionar situaciones reales de conocimiento en torno a una temática específica. Implementa los principios de la investigación formativa, como herramienta para generar nuevas alternativas en la apropiación del conocimiento. Este estudio tuvo como objetivo conocer la percepción de los estudiantes del programa Regencia de Farmacia frente a la utilización del aprendizaje basado en problemas con el fin de realizar aportes al currículo. Materiales y Métodos: Estudio descriptivo y transversal realizado con una muestra no probabilística, por conveniencia, conformada por 109 estudiantes de segundo a sexto semestre. Se elaboró un cuestionario con escala tipo Likert, sometido a valoración por expertos. Resultados: En general, los estudiantes están de acuerdo con la estrategia porque ha permitido acercarse a la investigación, fortaleciendo el pensamiento crítico; generando autonomía y responsabilidad frente al aprendizaje. A medida que avanzan los semestres, le ven mayor utilidad. Sin embargo, falta claridad en el uso de la metodología y capacitación por parte de algunos docentes para desarrollarla eficazmente. Discusión: La coordinación docente es fundamental, se debe fortalecer este aspecto para dar claridad al uso de la metodología. Implementar procesos de evaluación para determinar los avances desarrollados por los estudiantes y el impacto generado. Conclusiones: Los estudiantes consideran que adquieren conocimientos y competencias que les ayudarán en la práctica profesional. Cómo citar este artículo: Valderrama ML, Castaño GA. Solucionando dificultades en el aula: una estrategia usando el aprendizaje basado en problemas. Rev Cuid. 2017; 8(3): 1907-18. http://dx.doi.org/10.15649/cuidarte.v8i3.456
Exploring the relationship of threshold concepts and Hodges’ model of care from the individual to populations and global health
Authors: Jones Peter 
Published: September 2017

Through academia, professional disciplines seek – whenever possible – to base their actions on theory rather than fact and historical practices. This serves to improve certainty and place curricula, research, and practice on the best footing in terms of knowledge and quality. This emphasis extends to the workplaces in which professionalised disciplines are learned and practised. In healthcare, great importance is placed upon evidence-based findings to support clinical practice. Although subject to ongoing debate, the quality of research is assessed against a yardstick that culminates in a ‘gold-standard’ of clinical trials and systematic reviews. What healthcare professionals do, should, whenever possible, be based upon evidence, not ritualised practices and missives, such as “I was trained this way” and “This is how we do things here”.How to cite this article: Jones P. Exploring the relationship of threshold concepts and Hodges’ model of care from the individual to populations and global health. Rev Cuid. 2017; 8(3): 1697-720. http://dx.doi.org/10.15649/cuidarte.v8i3.464
Optimal timing of laparoscopic cholecystectomy after endoscopic retrograde cholangiopancreatography
Authors: Sahoo Rasmiranjan , Samal Debasish , Pradhan A. , Sultana Rima , Nayak Nabakishore , Padhy Rabindra Nath 
Published: September 2017

Background: Nowadays in patients with cholelithiasis with choledocholithiasis, the ideal treatment is endoscopic retrograde cholangiopancreatographic (ERCP) removal of duct stone and laparoscopic cholecystectomy. But when to do and whether we can do it simultaneously or one after another and what interval should be there, that is always controversial. The purpose was an optimal gap for cholecystectomy after ERCP.Methods: We have done a comparison study in 60 patients within a duration of 2 year who had already done ERCP. Group 1, those patients who had laparoscopic cholecystectomy within 72 hours compared with group 2 who had laparoscopic cholecystectomy after an interval of 6 week. Primary outcome was the conversion rate from lap to open cholecystectomy. Secondary outcome was duration of operation, intra-operative difficulties, postoperative morbidity and hospital stay.Results: Of 60 consecutive patients 30 were in group I and 30 were in group II. There is no difference in demographics, laboratory or ultrasonographic findings. The hospital stays in group I is significantly shorter than group II and conversion rate; operative time is higher in group II. No statistically significant difference in post-operative morbidity between both groups.Conclusions: Early laparoscopic cholecystectomy within 72 hr is better than interval (6 week) cholecystectomy after ERCP with shorter hospital stay and less intraoperative difficulties.
A prospective study to evaluate the utility of Mannheim peritonitis index in predicting prognosis of perforation peritonitis at our tertiary care centre
Authors: K. V. Saravanan , Alagarsamy Gowri Sankar , Sankar Udhaya 
Published: September 2017

Background: This study was aimed to evaluate the validity of Mannheim Peritonitis Index (MPI) in predicting the outcome in patients with perforation peritonitis.Methods: A prospective study was designed for a study period of 2 years, 75 patients who underwent operation for perforation peritonitis were included in the study. Post evaluation done with predesigned proforma, MPI score was calculated and analyzed for each patient who underwent surgery, death being the main outcome measure. The MPI scores were divided into three categories. MPI scores <15 (category 1), 16-25 (category 2), and >25 (category 3).Results: Present study consisted of 60 males and 15 females (male:female ratio of 4:1) with the mean patients age 37.96±17.49 years. 47, 26, and 27 cases belonged to MPI score categories 1, 2, and 3. The dominating source of perforation was small intestinal. The individual parameters of MPI score were assessed against the mortality, age >50 years (P = 0.015), organ failure (P = 0.0001), noncolonic origin of sepsis (P = 0.002), and generalized peritonitis (P = 0.0001) were the factors significantly associated with mortality. The sensitivity of MPI was 92% and specificity was 78% in receiver operating characteristic curves.Conclusions: MPI is an effective tool for prediction of mortality in cases of perforation peritonitis.
Endoscopic management of foreign bodies in the upper gastrointestinal tract
Authors: Mirji Pramod , Daddenavar Vikas , Kalburgi Eshwar 
Published: September 2017

Background: Foreign body ingestion and food bolus impaction is a common clinical scenario and can present as an endoscopic emergency. Though majority of them pass spontaneously 10-20% require endoscopic intervention. Flexible endoscopy is recommended as therapeutic measure with minimal complications. The aim of our study is to present 2 years’ experience in dealing with foreign bodies in the upper gastrointestinal tract.Methods: Cases of foreign body (FB) ingestion admitted to department of general surgery from January 2015 to December 2016 were evaluated. The patients were reviewed with details on age, sex, type of FB, its location in gastrointestinal tract, treatment and outcome.Results: A total of 23 cases were studied. Age range was 2-75 years. Males were predominant (60.87%). Coins were found most commonly (52.17%). Esophagus was the commonest site of FB lodgment (65.22%). Upper esophagus being the most common (39.13%). Upper gastrointestinal flexible endoscopy was useful in retrieving FB in all the 23 cases. There were no complications throughout the study period.Conclusions: Flexible endoscopy should be used as definitive treatment and endoscopic treatment is safe and effective.