bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intégration des besoins spirituels dans un service de médecine palliative
Authors: Morard Caroline , Zulian Gilbert 
Published: February 2017

La spiritualité englobe plusieurs concepts, allant du plaisir des choses simples aux questions plus fondamentales du sens de la vie et de la mort. Afin d’évaluer les besoins en matière de spiritualité, nous avons mené une étude ouverte dans un service spécialisé de médecine palliative situé dans un canton où la laïcité et la neutralité religieuse sont la règle. Avec l’accord de la commission d’éthique suisse relative à la recherche sur l’être humain et celui de l’organisation FACIT nous avons utilisé la version française du questionnaire Functional Assessment of Chronic Illness Therapy Scale-Spirituality. Il comprend 40 questions réparties en 5 catégories : le bien-être physique, familial et social, émotionnel, fonctionnel et spirituel, quantifiés sur les 7 derniers jours pour un total maximal de 156 points. Quatorze patients ont été inclus, obtenant des scores de 62 à 120 points. Toutefois, la passation du questionnaire s’est avérée problématique ; la plupart des patients n’ont pu lire les questions eux-mêmes en raison de leur état de santé précaire ; ils ont éprouvé des difficultés à quantifier leurs besoins ; certains sans plus aucun but dans la vie ont semblé mieux apaisés que d’autres avec un but bien précis ; partager leur vécu a prévalu sur quantifier leurs besoins ; et expliquer leur sérénité ou au contraire leur peur face à la mort a été très important pour eux. Malgré la présence d’une réelle souffrance spirituelle chez tous les patients, la spiritualité est apparue difficilement quantifiable dans notre contexte culturel hospitalier. La fragmenter équivaut peut-être à enfermer l’esprit alors qu’il s’agit de lui reconnaître sa liberté. D’autres outils que le questionnaire FACIT-SP mériteraient donc d’être développés pour mieux correspondre aux attentes des patients et aux réalités des professionnels.
Pour une éthique du pli
Authors: Bryant Levi R. , Bisson Frédéric 
Published: February 2017

Comment se fait-il qu’un corps en vienne à penser qu’il devrait être quelque chose, que le monde devrait être quelque chose, plutôt que d’être purement ce qu’il est ? L’éthique est la manière dont les corps plient le temps en eux-mêmes et, en particulier, la manière dont les êtres plient le futur en eux-mêmes, dans leur devenir relié au monde qu’ils impliquent. Le grand ennemi d’une éthique du pli est l’abstraction, quand nous pensons les corps comme des « objets », comme s’ils étaient de micro-souverains séparés de leur champ.
Réduction des émissions des CO 2 chinoises et gaz de schiste
Authors: Hubert Marie-Hélène 
Published: February 2017

Afin de diminuer ses émissions de CO 2 , le gouvernement chinois vise à accroître la part du gaz, notamment en extrayant les réserves de gaz de schiste chinoises. Le gaz de schiste peut fournir 10 % de la consommation d’énergie d’ici 2030 si son coût d’extraction diminue d’un tiers. Toutefois, les émissions de CO 2 chinoises augmentent de 5 %. Une politique imposant la stagnation de la consommation de charbon favorise l’extraction du gaz de schiste à grande échelle et diminue les émissions de CO 2 de 41 %. En revanche, une taxe sur les émissions de CO 2 ralentit le développement du gaz de schiste au profit des énergies renouvelables.
Evaluation of anthropogenic secondary organic aerosol tracers from aromatic hydrocarbons
Authors: Al-Naiema Ibrahim M. , Stone Elizabeth A. 
Published: February 2017

Abstract. Products of secondary organic aerosol (SOA) from aromatic volatile organic compounds (VOCs) – 2,3-dihydroxy-4-oxopentanoic acid, dicarboxylic acids, nitromonoaromatics, and furandiones – were evaluated for their potential to serve as anthropogenic SOA tracers with respect to their (1) ambient concentrations and detectability in PM2.5 in Iowa City, IA, USA; (2) gas–particle partitioning behaviour; and (3) source specificity by way of correlations with primary and secondary source tracers and literature review. A widely used tracer for toluene-derived SOA, 2,3-dihydroxy-4-oxopentanoic acid was only detected in the particle phase (Fp = 1) at low but consistently measurable ambient concentrations (averaging 0.3 ng m−3). Four aromatic dicarboxylic acids were detected at relatively higher concentrations (9.1–34.5 ng m−3), of which phthalic acid was the most abundant. Phthalic acid had a low particle-phase fraction (Fp =  0.26) likely due to quantitation interferences from phthalic anhydride, while 4-methylphthalic acid was predominantly in the particle phase (Fp = 0.82). Phthalic acid and 4-methylphthalic acid were both highly correlated with 2,3-dihydroxy-4-oxopentanoic acid (rs = 0.73, p = 0.003; rs = 0.80, p < 0.001, respectively), suggesting that they were derived from aromatic VOCs. Isophthalic and terephthalic acids, however, were detected only in the particle phase (Fp = 1), and correlations suggested association with primary emission sources. Nitromonoaromatics were dominated by particle-phase concentrations of 4-nitrocatechol (1.6 ng m−3) and 4-methyl-5-nitrocatechol (1.6 ng m−3) that were associated with biomass burning. Meanwhile, 4-hydroxy-3-nitrobenzyl alcohol was detected in a lower concentration (0.06 ng m−3) in the particle phase only (Fp = 1) and is known as a product of toluene photooxidation. Furandiones in the atmosphere have only been attributed to the photooxidation of aromatic hydrocarbons; however the substantial partitioning toward the gas phase (Fp  ≤  0.16) and their water sensitivity limit their application as tracers. The outcome of this study is the demonstration that 2,3-dihydroxy-4-oxopentanoic acid, phthalic acid, 4-methylphthalic acid, and 4-hydroxy-3-nitrobenzyl alcohol are good candidates for tracing SOA from aromatic VOCs.
Procesos de Apropriación Espacial y Desigualdades Sociales En El Centro Histórico De Puebla / Processes of spatial appropriation and social inequalities in the Historic Center of Puebla
Authors: Alvarez Moura Alfonso , Valverde Díaz de León Francisco 
Published: February 2017

RESUMENVinculación entre formas de intervención en la ciudad y procesos de apropiación socio-espaciales en el Centro Histórico de Puebla. Analizaremos casuísticas concretas de desposesión-apropiación espacial que ahondan en las desigualdades sociales. Con todo ello, pretendemos constatar la relación entre el uso que se hace del Centro Histórico y la apropiación social de clase de que está siendo objeto.Palabras clave: Centros Históricos, Patrimonio Urbano, Renovación Urbana. RESUMOLigando formas de intervenção na cidade e processos de apropriação socioespacial no centro histórico de Puebla. Discutimos o número de casos específicos de espaço desapropriação - apropriadora que mergulhar em desigualdades sociais . Com tudo isso , pretende-se verificar a relação entre a utilização do Centro Histórico e classe apropriação social que é o assunto. Palavras-chave: Centros históricos , património urbano , renovação urbana. ABSTRACTLinking forms of intervention in the city and processes of socio- spatial appropriation in the historic center of Puebla. We discuss specific caseloads of dispossession - appropriating space that delve into social inequalities. With all this, we intend to verify the relationship between the use made of the Historical Center and social appropriation class that is the subject.Keywords: Historic Centers, Heritage Urban, Urban Renewal.
Encuentros y Desencuentros de La Modernidad en Tegucigalpa, Siglo XIX y XX. / Agreements and disagreements of modernity in Tegucigalpa, Nineteenth and twentieth century
Authors: Navarrete Calix Daniela 
Published: February 2017

RESUMENEste artículo analiza el impacto urbano que trajo la modernidad política aplicada a la ciudad de Tegucigalpa, capital de Honduras. Para ello comparamos diacrónicamente la transformación político-administrativa en este centro urbano: en el liberalismo del último cuarto del siglo XIX y principios del s. XX; y en el neoliberalismo de finales del siglo XX. El discurso de los locutores de la modernidad liberal y neoliberal tendrá especial atención, pues vehicula los ideales de los gobernantes para alcanzar el progreso o desarrollo. Estos anhelos de modernidad se reflejan en el paisaje urbano encontrándose o no de los anhelos de los ciudadanos de esta capital centroamericana.Palabras clave: modernidad – (neo) liberalismo – modelos urbanos RESUMO Este artigo analisa o impacto urbano que trouxe modernidade política aplicada à cidade de Tegucigalpa, capital de Honduras. Para esta comparação diacronicamente a transformação político-administrativa neste centro urbano: no liberalismo do último quartel do século XIX e início do s. XX; eo neoliberalismo do final do século XX. O discurso dos oradores da modernidade liberal e neoliberal terá atenção especial, pois transmite os ideais dos governos para alcançar o progresso ou desenvolvimento. Esses anseios da modernidade são refletidos na paisagem urbana ou não corresponder às aspirações dos cidadãos desta capital centro-americana.Palavras-chave: modernidade - (neo) liberalismo – modelos Urbanos ABSTRACTThis article analyzes the urban impact that brought political modernity applied to the city of Tegucigalpa, capital of Honduras. For this we compare diachronically the political-administrative transformation in this urban center: during liberalism of the last quarter of the nineteenth century and early s. XX; and during the neoliberalism of the late twentieth century. The speech of the speakers of liberal and neoliberal modernity will have special attention, as conveys the ideals of governments to achieve progress or development. These yearnings of modernity are reflected in the urban landscape and of course meet and unmeet the aspirations of the citizens of this Central American capital.Keywords: modernity – (neo) liberalism – urban models
SÃO JOSÉ DO NORTE (RS/BRASIL): MEIO AMBIENTE COMO MERCADORIA/ SÃO JOSÉ DO NORTE (RS/BRAZIL): ENVIRONMENT AS A MERCHANDISE
Authors: Dos Santos Caio Floriano , Puccinelli Vinicius Ramos , Oliveira Cleiton Luiz de , Mascarello Marcela de Avellar , Machado Carlos RS 
Published: February 2017

RESUMOSão José do Norte- RS passa por grandes transformações na matriz econômica que marca o cotidiano dos habitantes. Tais transformações são propagandeadas por gestores municipais, empreendedores e jornalistas como a "vinda do progresso". O objetivo deste trabalho é analisar estas mudanças elucidando o discurso neodesenvolvimentista que embasa a aceitação dos Grandes Projetos de Desenvolvimento (GPD's). Para isso, utilizamos textos do sítio eletrônico da prefeitura, reportagens, entre outros. Como metodologia, fizemos a análise de discurso de tais materiais, que revelam o esforço de gestores para vender o município como propício para a instalação de GPD’s.Palavras-chave: Grandes Projetos de Desenvolvimento; mercadoria; progresso. RESUMENSão José do Norte- RS ha pasado por grandes cambios en la matriz económica que marca el cotidiano de los habitantes. Eses cambios son publicitados por gestores municipales, empresarios y periodistas como la “llegada del progreso”. El objetivo del artículo es analizar eses cambios, elucidando el discurso neodesarrollista que basa la aceptación de los Grandes Proyectos de Desarrollo (GPD´s). Para esto, utilizamos textos del sitio electrónico de la intendencia, informes, entre otros. Como metodología, hicimos el análisis de discurso de estos materiales, que revelan el esfuerzo de los gestores para vender la municipalidad como propicio para la instalación de GPD’s.Palabras clave: Grandes Proyectos de Desarrollo; mercancía; progreso. ABSTRACTSão José do Norte-RS goes through great economic changes which cause a direct impact in the everyday-life of the citizens of the city. These changes are publicised by municipal managers, entrepreneurs and journalists as “progress coming for the city”. The aim of this study is to analyze the acceptance of Grandes Projetos de Desenvolvimento (GPD’s). For this, we have used as data, the articles from the website of the City Hall and reports, among others. As the methodology, we have used the discourse analyze of those materials, which reveal the efforts of the managers to sell the city as an auspicious place for the installation of GPD’s.Keywords: Grandes Projetos de Desenvolvimento; merchandise; progress.
Sobre a impossibilidade de se voltar para casa ou a escrita como o lugar possível voltado para o futuro/On the impossibility to back home or written as possible place back to the future
Authors: Marandola Jr. Eduardo 
Published: February 2017

RESUMOMeditação sobre o sentido do lugar possível, a escrita, como pensamento voltado para o futuro, o texto se constitui como experiência, composto por interstícios literários de uma tessitura geográfico-política sobre as geometrias do pensamento.Palavras-chave: geometrias do pensamento; literatura; lugar possível RESUMENLa meditación sobre el significado de la posible lugar, la escritura y el pensamiento de vuelta al futuro, el texto se constituye como la experiencia, que consiste en intersticios literarias de un tejido geográfico-política de las geometrías de pensamiento.Palabras clave: la geometría del pensamiento; literatura; lugar posible ABSTRACTMeditation on the meaning of the possible place, writing, and thinking back to the future, the text is as experience, composted by literary interstices of the geographical-political compose of the geometries of thought.Keywords: thinking geometries; literature; possible place
Triaging Patients with Multiple Sclerosis in the Emergency Department
Authors: Abboud Hesham , Mente Karin , Seay Meagan , Kim Jeffrey , Ali Ashhar , Bermel Robert , Willis Mary A. 
Published: February 2017

Background:Patients with multiple sclerosis (MS) present to the emergency department (ED) for various reasons. Although true relapse is rarely the underlying culprit, ED visits commonly result in new magnetic resonance imaging (MRI) and neurology admissions. We studied ED visits in patients with MS and evaluated decision making regarding diagnostic/therapeutic interventions and visit outcomes. We identified potential areas for improvement and used the data to propose a triaging algorithm for patients with MS in the ED.Methods:We reviewed the medical records from 176 ED visits for patients with MS in 2014.Results:Ninety-seven visits in 75 patients were MS related (66.6% female; mean ± SD age, 52.6 ± 13.8 years; mean ± SD disease duration, 18.5 ± 10.5 years). Thirty-three visits were for new neurologic symptoms (category 1), 29 for worsening preexisting symptoms (category 2), and 35 for MS-related complications (category 3). Eighty-nine visits (91.8%) resulted in hospital admission (42.7% to neurology). Only 39% of ordered MRIs showed radiographic activity. New relapses were determined in 27.8% of the visits and were more prevalent in category 1 compared with category 2 (P = .003); however, the two categories had similar rates of ordered MRIs and neurology admissions.Conclusions:New relapse is a rare cause of ED visits in MS. Unnecessary MRIs and neurology admissions can be avoided by developing a triaging system for patients with MS based on symptom stratification.
Perceived compliance and barriers to care in sublingual immunotherapy
Authors: Kumar Manvinder S. , Oh Melissa S. , Leader Brittany , Rotella Melissa , Stillman Leisa , DelGaudio John M. , Wise Sarah K. 
Published: February 2017

BackgroundFor allergy immunotherapy to be effective, patient compliance is critical. However, aqueous sublingual immunotherapy (SLIT) may be considered demanding for patients, requiring strict daily dosing and refilling of medication at regular intervals. In this study we sought to determine how patients perceive their own compliance with SLIT and identify barriers that may hinder compliance.MethodsUsing a retrospective review, 46 patients currently undergoing aqueous SLIT were identified to have less‐than‐excellent compliance based on frequency of clinic visits for SLIT refills. Twenty‐eight of these patients completed a phone survey regarding symptom improvement, compliance, and barriers to care. In addition, 56 patients who withdrew from therapy before completion were polled about barriers to adherence.ResultsOf the 28 patients participating in the initial phone survey, 24 (86%) reported subjective improvement in symptoms on SLIT, despite less‐than‐excellent compliance. Nineteen (68%) of these patients perceived their own compliance to be excellent. Eighteen patients (65%) reported the inconvenience of scheduling and attending clinic appointments to be the main reason for noncompliance. The most common reasons for withdrawal from therapy were cost (27%), lack of effectiveness (25%), and difficulty with compliance (14%).ConclusionThe majority of aqueous SLIT patients perceived their compliance to be excellent, although, based on a previous study, these patients did not reach excellent compliance benchmarks. Inconvenience of clinic visits and cost of therapy were found to be the most common barriers to care. Despite what providers perceived as less‐than‐excellent compliance, 82% of patients reported symptom improvement with SLIT.
Cooperative Subunit Refolding of a Light‐Harvesting Protein through a Self‐Chaperone Mechanism
Authors: Laos Alistair J. , Dean Jacob C. , Toa Zi S. D. , Wilk Krystyna E. , Scholes Gregory D. , Curmi Paul M. G. , Thordarson Pall 
Published: February 2017

AbstractThe fold of a protein is encoded by its amino acid sequence, but how complex multimeric proteins fold and assemble into functional quaternary structures remains unclear. Here we show that two structurally different phycobiliproteins refold and reassemble in a cooperative manner from their unfolded polypeptide subunits, without biological chaperones. Refolding was confirmed by ultrafast broadband transient absorption and two‐dimensional electronic spectroscopy to probe internal chromophores as a marker of quaternary structure. Our results demonstrate a cooperative, self‐chaperone refolding mechanism, whereby the β‐subunits independently refold, thereby templating the folding of the α‐subunits, which then chaperone the assembly of the native complex, quantitatively returning all coherences. Our results indicate that subunit self‐chaperoning is a robust mechanism for heteromeric protein folding and assembly that could also be applied in self‐assembled synthetic hierarchical systems.
Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics
Authors: Gao Shu‐Shan , Wang Luoyi , Song Zhongshu , Hothersall Joanne , Stevens Elton R. , Connolly Jack , Winn Peter J. , Cox Russell J. , Crump Matthew P. , Race Paul R. , Thomas Christopher M. , Simpson Thomas J. , Willis Christine L. 
Published: February 2017

AbstractThiomarinol and mupirocin are assembled on similar polyketide/fatty acid backbones and exhibit potent antibiotic activity against methicillin‐resistant Staphylococcus aureus (MRSA). They both contain a tetrasubstituted tetrahydropyran (THP) ring that is essential for biological activity. Mupirocin is a mixture of pseudomonic acids (PAs). Isolation of the novel compound mupirocin P, which contains a 7‐hydroxy‐6‐keto‐substituted THP, from a ΔmupP strain and chemical complementation experiments confirm that the first step in the conversion of PA‐B into the major product PA‐A is oxidation at the C6 position. In addition, nine novel thiomarinol (TM) derivatives with different oxidation patterns decorating the central THP core were isolated after gene deletion (tmlF). These metabolites are in accord with the THP ring formation and elaboration in thiomarinol following a similar order to that found in mupirocin biosynthesis, despite the lack of some of the equivalent genes. Novel mupirocin–thiomarinol hybrids were also synthesized by mutasynthesis.
Efficient Difluoromethylation of Alcohols Using TMSCF2Br as a Unique and Practical Difluorocarbene Reagent under Mild Conditions
Authors: Xie Qiqiang , Ni Chuanfa , Zhang Rongyi , Li Lingchun , Rong Jian , Hu Jinbo 
Published: February 2017

AbstractA general method for the efficient difluoromethylation of alcohols using commercially available TMSCF2Br (TMS=trimethylsilyl) as a unique and practical difluorocarbene source is developed. This method allows primary, secondary, and even tertiary alkyl difluoromethyl ethers to be synthesized under weakly basic or acidic conditions. The reaction mainly proceeds through the direct interaction between a neutral alcohol and difluorocarbene, which is different from the difluoromethylation of phenols. Moreover, alcohols containing other moieties that are also reactive toward difluorocarbene can be transformed divergently by using TMSCF2Br. This research not only solves the synthetic problem of difluorocarbene‐mediated difluoromethylation of alcohols, it also provides new insights into the different reaction mechanisms of alcohol difluoromethylation and phenol difluoromethylation with difluorocarbene species.
A Naphtho‐Fused Double [7]Helicene from a Maleate‐Bridged Chrysene Trimer
Authors: Ferreira Marli , Naulet Guillaume , Gallardo Hugo , Dechambenoit Pierre , Bock Harald , Durola Fabien 
Published: February 2017

AbstractPerkin condensation of chrysenyl‐6‐acetic acid with chrysenylene‐6,12‐diglyoxylic acid followed by in situ esterification gives a bismaleate, whose conjugated stilbene moieties are efficiently shielded against intermolecular condensations and undergo iodine‐catalyzed oxidative photocyclization in toluene without the need for high dilution. The concentration is limited by the low solubility of the flexible bismaleate at room temperature. The so‐obtained double [7]helicene crystallizes in a nonchiral meso form. It is notably more soluble than its flexible precursor because it cannot fold to optimize π–π stacking.
Flexible epoxy novolac coatings: Use of cardanol‐based flexibilizers
Authors: Gour Rajeshwari S. , Raut Kundalik G. , Badiger Manohar V. 
Published: February 2017

ABSTRACTFlexible epoxy novolac coatings were developed by reacting an epoxy novolac resin, poly[(phenylglycidyl ether)‐co‐formaldehyde] (PPGEF) with an amine curing agent, 4,4′‐diamino‐3,3′‐dimethyldicyclohexyl methane (BMCHA), cardanol based reactive diluent (Cardolite NC‐513) and two different cardanol‐based flexibilizers (Cardolite NC‐514 and Cardolite NC‐547). The flexibilizer content was varied from 5 to 10% by weight of the resin. These resins were coated onto the stainless steel panels and tested for their gloss, cross‐hatch adhesion, falling weight impact resistance, flexibility, abrasion, scratch hardness, solvent scrub resistance, and chemical resistance. The thermo‐mechanical properties of these coatings were determined by TGA, DSC, DMTA, and tensile strength measurements. The cryofractured specimens were subjected to SEM analysis. The influence of structural differences of two flexibilizers on the coating properties was investigated. These coatings exhibited excellent properties and have great potential in industrial applications. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44920.