bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equine glucagon-like peptide-1 receptor physiology
Authors: Kheder Murad H. , Bailey Simon R. , Dudley Kevin J. , Sillence Martin N. , de Laat Melody A. 
Published: January 2018

Background
Equine metabolic syndrome (EMS) is associated with insulin dysregulation, which often manifests as post-prandial hyperinsulinemia. Circulating concentrations of the incretin hormone, glucagon-like peptide-1 (GLP-1) correlate with an increased insulin response to carbohydrate intake in animals with EMS. However, little is known about the equine GLP-1 receptor (eGLP-1R), or whether GLP-1 concentrations can be manipulated. The objectives were to determine (1) the tissue localisation of the eGLP-1R, (2) the GLP-1 secretory capacity of equine intestine in response to glucose and (3) whether GLP-1 stimulated insulin secretion from isolated pancreatic islets can be attenuated.

Methods
Archived and abattoir-sourced tissues from healthy horses were used. Reverse transcriptase PCR was used to determine the tissue distribution of the eGLP-1R gene, with immunohistochemical confirmation of its pancreatic location. The GLP-1 secretion from intestinal explants in response to 4 and 12 mM glucose was quantified in vitro. Pancreatic islets were freshly isolated to assess the insulin secretory response to GLP-1 agonism and antagonism in vitro, using concentration-response experiments.

Results
The eGLP-1R gene is widely distributed in horses (pancreas, heart, liver, kidney, duodenum, digital lamellae, tongue and gluteal skeletal muscle). Within the pancreas the eGLP-1R was immunolocalised to the pancreatic islets. Insulin secretion from pancreatic islets was concentration-dependent with human GLP-1, but not the synthetic analogue exendin-4. The GLP-1R antagonist exendin 9-39 (1 nM) reduced (P = 0.08) insulin secretion by 27%.

Discussion
The distribution of the eGLP-1R across a range of tissues indicates that it may have functions beyond insulin release. The ability to reduce insulin secretion, and therefore hyperinsulinemia, through eGLP-1R antagonism is a promising and novel approach to managing equine insulin dysregulation.
Incidence of and social-demographic and obstetric factors associated with postpartum depression: differences among ethnic Han and Kazak women of Northwestern China
Authors: Chen Ling , Ding Li , Qi Ming , Jiang Chao , Mao Xin-Min , Cai Wen-Zhi 
Published: January 2018

Background
Studies on postpartum depression (PPD) in China have focused primarily on women of Han ethnicity, whereas work on other ethnic groups has proven limited. This study explored the ethnic differences of associated social-demographic and obstetric factors for PPD between Han-majority and Kazak-minority women in northwestern China.

Methods
Han and Kazak women who received routine examinations at four hospitals in a multi-ethnic area of China six weeks after childbirth between March 2016 and December 2016 were included in the study. Data on the women’s socio-demographic characteristics, obstetric factors, and possible depression at six weeks after childbirth were collected. We examined the associated factors of PPD using multivariable logistic regression analyses by ethnic group.

Results
The overall incidence of PPD was 14.6% (184/1,263) at six weeks after childbirth. PPD was detected more frequently among Kazak (16.1%) than Han women (13.1%). Kazak women exhibited a higher risk of PPD (adjusted OR = 1.561, 95% CI [1.108–2.198], P = 0.011). Urinary incontinence (UI) represented a significant risk factor of PPD for Kazak compared with Han women (OR = 1.720, 95% CI [1.056–2.804], P = 0.003). In contrast, the presence of the mother-in-law as a caregiver after childbirth demonstrated a positive association with PPD among Han (OR = 2.600, 95% CI [1.499–4.512], P = 0.001), but not with Kazak women.

Conclusions
Kazak women were more likely to develop PPD than Han women, even after controlling for confounders. Moreover, distinct risk factors for PPD existed for Han and Kazak women. Future research that explores the relationships between Han women and their mothers-in-law as well as Kazak women’s attitudes toward UI could help us further understand PPD in these populations.
УСРЕДНЕНИЕ КРАЕВОЙ ЗАДАЧИ ДЛЯ ОПЕРАТОРА ЛАПЛАСА В ОБЛАСТИ, ПЕРФОРИРОВАННОЙ ВДОЛЬ (N - 1)-МЕРНОГО МНОГООБРАЗИЯ, С НЕЛИНЕЙНЫМ КРАЕВЫМ УСЛОВИЕМ РОБИНА НА ГРАНИЦЕ ПОЛОСТЕЙ ПРОИЗВОЛЬНОЙ ФОРМЫ: КРИТИЧЕСКИЙ СЛУЧАЙ, "Доклады Академии наук"
Authors: Подольский А.В. , Шапошникова Т.А. 
Published: January 2018

В сообщении исследуется асимптотическое поведение решения краевой задачи для оператора Лапласа в области, перфорированной вдоль (­n - 1)-мерного многообразия. Предполагается, что на границе полостей задано нелинейное краевое условие Робина. Основное отличие от предыдущих работ по этой тематике в том, что перфорация образована не шарами, а множествами произвольной формы (точнее множествами, диффеоморфными шару). Построена усреднённая модель и доказана сходимость решений исходных задач к решению усреднённой.
АНАЛИТИЧЕСКОЕ РЕШЕНИЕ УРАВНЕНИЙ ФИЗИЧЕСКОЙ ТЕОРИИ МЕТЕОРОВ ДЛЯ ЕДИНОГО (НЕ ДРОБЯЩЕГОСЯ) ТЕЛА С ПОТЕРЕЙ МАССЫ В НЕИЗОТЕРМИЧЕСКОЙ (ПРОИЗВОЛЬНОЙ) АТМОСФЕРЕ С ПЕРЕМЕННЫМ ПАРАМЕТРОМ УНОСА МАССЫ, "Доклады Академии наук"
Authors: Тирский Г.А. 
Published: January 2018

Получено аналитическое решение двух совместных обыкновенных дифференциальных уравнений физической теории метеоров: уравнение движения центра массы метеороида (уравнение торможения), уравнение теплового баланса (уравнение уноса массы), уравнение свечения и уравнение ионизационного следа. Решение получено при предположении прямолинейной траектории и степенной зависимости параметра уноса массы от скорости метеороида для произвольной атмосферы в континуальном режиме обтекания.
РОСТ И МОРФОЛОГИЯ МОНОКРИСТАЛЛОВ ВЫСОКОГЕРМАНИЕВОГО КВАРЦА, "Доклады Академии наук"
Authors: Балицкий В.С. , Балицкий Д. В. , Пущаровский Д.Ю. , Сеткова Т.В. , Балицкая Л.В. , Некрасов А.Н. 
Published: January 2018

Приведены экспериментальные данные по выращиванию и исследованию монокристаллов высокогерманиевого кварца, обладающего лучшими, чем у чистого кварца, пьезоэлектрическими характеристиками и работоспособностью при более высоких температурах и давлениях.
МЕТЕОРИТ “КАРГАПОЛЬЕ”: НОВЫЕ ДАННЫЕ ПО МИНЕРАЛОГИИ, "Доклады Академии наук"
Authors: Ерохин Ю.В. , Коротеев В.А. , Хиллер В.В. , Бурлаков Е.В. , Иванов К.С. , Клейменов Д.А. 
Published: January 2018

Дополнены данные о минеральном составе метеорита “Каргаполье”, найденного на территории Курганской области в 1961 г. Установлено, что космическое вещество сложено оливином (хризолит), ортопироксеном (бронзит), клинопироксеном (диопсид), плагиоклазом (олигоклаз), хромитом, металлами Fe, Ni (камасит, тэнит, тетратэнит), сульфидами (троилит, пентландит), хлорапатитом, мерриллитом. При этом диопсид, тетратэнит, пентландит, хлорапатит, мерриллит определены в метеорите “Каргаполье” впервые. Для всех минералов приведены данные по химическому составу. Сам метеорит - обыкновенный каменный хондрит и относится к петрологическому типу H4.
ПАЛЕОПРОТЕРОЗОЙСКИЙ КАНДАЛАКШСКИЙ АНОРТОЗИТОВЫЙ МАССИВ: НОВЫЕ ДАННЫЕ О ВОЗРАСТЕ (U-PB, ID-TIMS) И ГЕОХИМИЧЕСКИХ ОСОБЕННОСТЯХ ЦИРКОНА, "Доклады Академии наук"
Authors: Стешенко Е.Н. , Николаев А.И. , Баянова Т.Б. , Дрогобужская С.В. , Чащин В.В. , Серов П.А. , Лялина Л.М. , Новиков А.И. 
Published: January 2018

Для Кандалакшско-Колвицкой зоны Балтийского щита получены новые U-Pb-, Sm-Nd-изотопные данные по акцессорным зёрнам циркона, рутила, породе и вторичным метаморфическим минералам. Изотопный U-Pb-возраст единичных зёрен циркона, выделенных из метагаббро Кандалакшского анортозитового массива, равен 2453,5 ± 4,8 млн лет и близок U-Pb-возрасту циркона из метагаббро Колвицкого массива (2448 ± 5 млн лет). Впервые измерены концентрации и построены графики распределений REE в зёрнах циркона из метагаббро Кандалакшского массива и рассчитана температура закрытия U-Pb-системы и кристаллизации циркона (844°C) с использованием метода LA-ICP-MS. Совокупность новых изотопно-геохимических данных свидетельствует о магматическом генезисе изученных кристаллов циркона.
О РАСПРЕДЕЛЕНИИ ВЕРОЯТНОСТЕЙ ЭКСТРЕМАЛЬНЫХ ОСАДКОВ, "Доклады Академии наук"
Authors: Королев В.Ю. , Горшенин А. К. 
Published: January 2018

На основании отрицательной биномиальной модели распределения длины дождливых периодов, измеряемой в сутках, для распределения максимального суточного объёма осадков за дождливый ­период предложена асимптотическая модель, имеющая вид смеси распределений Фреше и совпадаю­щая с распределением положительной степени случайной величины, имеющей распределение Снедекора-Фишера. Метод доказательства соответствующего результата базируется на предельных теоремах для экстремальных порядковых статистик в выборках случайного объёма, имеющего смешанное пуас­соновское распределение. Адекватность предложенных моделей и методов их статистического анализа продемонстрирована на примере оценивания параметров экстремального распределения по реальным данным.
ВЛИЯНИЕ ЦИСПЛАТИНА НА ЦИТОТОКСИЧНОСТЬ ПРОТИВООПУХОЛЕВОГО ЦИТОКИНА TRAIL И?ЕГО РЕЦЕПТОРСЕЛЕКТИВНОГО МУТАНТНОГО ВАРИАНТА DR5-B, "Доклады Академии наук"
Authors: Гаспарян М.Э. , Бычков М.Л. , Яголович А.В. , Кирпичников М.П. , Долгих Д.А. 
Published: January 2018

Исследовали влияние химиопрепарата цисплатин на цитотоксичность противоопухолевого цитокина TRAIL и его рецепторселективного мутантного варианта DR5-B на 12 линиях опухолевых клеток разного происхождения. Цисплатин эффективно усиливал цитотоксическую активность препаратов TRAIL. Этот синергизм был наиболее выражен при исследовании клеточных линий рака простаты: результат совместного действия цисплатина и TRAIL превышал сумму их эффектов более чем в 2 раза. При этом вариант DR5-B значительно превосходил по своей цитотоксичности TRAIL дикого типа при использовании совместно с цисплатином на 9 из 12 линий опухолевых клеток.
Area‐Level Socioeconomic Status Impacts Health Care Visit Frequency by Australian Patients With Inflammatory Arthritis: Results From the Australian Rheumatology Association Database
Authors: Russell Oscar , Lester Susan , Black Rachel J. , Lassere Marissa , Barrett Claire , March Lyn , Lynch Tom , Buchbinder Rachelle , Hill Catherine L. 
Published: October 2024

ObjectiveIndividuals with inflammatory arthritis require long‐term rheumatologist care for optimal outcomes. We sought to determine if socioeconomic status (SES) influences general practitioner (GP) and specialist physician visit frequency and out‐of‐pocket (OOP) visit costs.MethodsWe linked data from Australian Rheumatology Association Database (ARAD) participants with rheumatoid arthritis or psoriatic arthritis to the Pharmaceutical Benefits (PBS) and Medicare Benefits Schedule from 2011 to 2018. Small‐area SES was approximated as quintiles of the Index of Relative Socioeconomic Advantage and Disadvantage. A comorbidity index (Rx‐Risk) was determined from PBS data. Analysis was performed using panel regression methods.ResultsWe included 1,916 ARAD participants (76.3% rheumatoid arthritis, 71.1% women, mean ± SD age 54 ± 12 years and disease duration 6 ± 4 years). Participants averaged 9.0 (95% confidence interval [CI] 8.6–9.4) annual GP visits and 3.9 (95% CI 3.8–4.1) annual specialist physician visits. After adjustment for sex, age, education, remoteness, and comorbidity, there was an inverse relationship between annual GP visit frequency and higher SES quintile (–0.6, 95% CI –0.9 to –0.3 visits per quintile) and a direct relationship between more frequent specialist visits and higher SES (linear slope 0.3, 95% CI 0.2–0.5 visits per quintile). Average OOP costs/visit were higher for specialist physician (AUD$38.43; 95% CI 37.34–39.53) versus GP visits (AUD$7.86; 95% CI 7.42–8.31), and higher SES was associated with greater OOP cost.ConclusionPatients with higher SES have relatively fewer GP visits and more specialist physician visits compared with patients with lower SES, suggesting individuals with lower SES may receive suboptimal specialist physician care. OOP costs may be a contributing factor.
Identification of a Non‐Commensurate Fractional‐Order Nonlinear System Based on the Separation Scheme
Authors: Wang Junwei , Xiong Weili , Ding Feng 
Published: October 2024

ABSTRACTThis article is aimed to study the parameter estimation problems of a non‐commensurate fractional‐order system with saturation and dead‐zone nonlinearity. In order to reduce the structural complexity of the system, the model separation scheme is used to decompose the fractional‐order nonlinear system into two subsystems, one includes the parameters of the linear part and the other includes the parameters of the nonlinear part. Then, we derive an auxiliary model separable gradient‐based iterative algorithm with the help of the model separation scheme. In addition, to improve the utilization of the real time information, an auxiliary model separable multi‐innovation gradient‐based iterative algorithm is presented based on the sliding measurement window. Finally, the feasibility of the presented algorithms is validated by numerical simulations.
Ultra‐Low Threshold Voltage in N‐Type Organic Electrochemical Transistors Enabled by Organic Mixed Ionic‐Electronic Conductors with Dual Electron‐Withdrawing Substitutions
Authors: Ding Riqing , Zhang Xiage , Yan Ran , Peng Meishan , Su Shengyao , Jeong Sang Young , Woo Han Young , Guo Xugang , Feng Kui , Guo Zi‐Hao 
Published: October 2024

AbstractAchieving low threshold voltage (Vth) in organic electrochemical transistors (OECTs) is essential for minimizing power consumption and enhancing sensitivity in bioelectronic devices. However, obtaining OECT materials with ultra‐low Vth, close to 0 V for n‐type conjugated polymers remains challenging. Here, a conjugated polymer FBDOPV‐CNTVT is introduced, which features a rigid backbone structure and high electron deficiency, leading to an exceptionally low lowest unoccupied molecular orbital (LUMO) energy level of −4.67 eV, achieved through dual electron‐withdrawing substitutions. With its ultra‐low LUMO energy level, FBDOPV‐CNTVT exhibits high susceptibility to electrochemical doping, even demonstrating efficient doping near 0 V. Consequently, the OECT device employing FBDOPV‐CNTVT as the active material shows an ultra‐low Vth of 7.5 mV, setting a new record for the Vth of n‐type OECT devices. Furthermore, FBDOPV‐CNTVT exhibits a µC* value of 6.13 F cm−1 V−1 s−1 and retains ≈85% of its current after 2000 s cycling. This study highlights the potential of conjugated polymers with dual electron‐withdrawing substitutions to achieve ultra‐low LUMO energy levels, effectively reducing the Vth of n‐type OECT devices and promising advancements in bioelectronics.
Continuous Phase Separation Induced Tough Hydrogel Fibers with Ultrahigh Conductivity for Multidimensional Soft Electronics
Authors: Wang Zhuang , Xu Xiaoyun , Zhang Ke , Tan Renjie , Zhang Shuai , Su Yupei , Hu Jinlian 
Published: October 2024

AbstractConductive hydrogel fibers exhibit great potential in soft robots, bioelectronics, and human–machine interfaces due to the unique combination of electrical conductivity, high water content, tissue‐like mechanical properties, and 1D structure. Despite significant advances in hydrogel technologies, the typical conductive hydrogel fibers show low conductivity (<10 S cm−1), weak mechanical properties, and water stability, which makes it challenging to satisfy the requirements of practical applications. Here, a facile strategy is proposed to construct hydrogel fibers with ultrahigh conductivity and toughness by exploiting the synergistic effects of freezing‐thawing, salting‐out, and drying‐annealing. The continuous phase separation induced by the combined processes results in hierarchical structures, promoting the formation of interconnected conductive networks and increasing the fiber's crystallinity and crystal domain size. The prepared conductive hydrogel fibers exhibited ultrahigh conductivity (≈958 S cm−1), excellent mechanical properties (strength (≈6.2 MPa), stretchability (>300%), and toughness (≈10 MJ m−2)), high water content (≈75%), outstanding water stability, and fatigue resistance properties. In addition, the processibility of conductive hydrogel yarns and fabrics are demonstrated and their potential application in bioelectronics. Overall, this work presents a preparation strategy for conductive hydrogel fibers, which will facilitate the advancement of soft electronics and may inspire structural construction in other polymers.
Filiform Papillae‐Inspired Wearable Pressure Sensor with High Sensitivity and Wide Detection Range
Authors: Li Gang , Zhang Yurong , Zhang Xiaolong , Zhu Bo , Lei Yifeng , Chen Daobing , Shui Langquan , Wu Guoqiang , Xue Longjian 
Published: October 2024

AbstractFlexible pressure sensor (FPS) has promising applications in fields like health monitoring and human–machine interactions. The achieving of both high sensitivity and wide detection range in FPS remains highly challenging. Here, inspired by the filiform papillae on cat tongue, a FPS (noted as FPSp) with a sensitivity up to 504.5 kPa−1, a detection range from 30 Pa to 350 kPa, a fast response time of 83 ms, and a high stability over 8000 cycles is developed. The papilla‐like structure continuously shifts the location of stress concentration under increasing pressure, which avoids the accumulation of stress at papillae tips, resulting in a high sensitivity and wide detection range. Moreover, FPSp demonstrates capabilities in monitoring human physiological signals and movement status and can serve as the human‐machine interaction interface. The work not only presents a promising wearable pressure sensor but also establishes a design strategy for high‐performance wearable bioelectronics.
In Situ Exsolved CuZn Alloy Electrocatalysts for CO2 Conversion to Tunable Syngas Production
Authors: Liu Ting , Luo Huihua , Ouyang Ting , Liu Zhao‐Qing 
Published: October 2024

AbstractAlloying is considered as a promising method for syngas (H2 and CO mixture gas) generation. However, it is challenging to elucidate the relationship between the ratios of syngas and alloy components for CO2 reduction reaction. Herein, through tuning the Cu/Zn ratio on CuZn alloy, the H2/CO ratios in CuZn‐2 (Cu/Zn = 0.77) can be tuned in a noticeable range between 0.8 and 5.8 at −0.88 to −1.28 V versus RHE, and a durable stability of 12 h. The CuZn‐2 displays better performance and enhanced dynamics than other samples. Electrochemical impedance spectroscopies and Tafel results reveal that CuZn‐2 behaves kinetically optimized performance. Density functional theory calculations results reveal that CuZn alloy exhibits middle desorption intensity of *H for HER compared with pure Zn and Cu. CuZn alloy effectively decreases the energy barrier of CO2 molecules activated to *COOH relative to Zn, and also the alloy renders it easier for *CO desorb to generate CO for Cu. In situ Fourier transform infrared spectroscopies also observe a significant intensity of *CO on CuZn‐2. This work demonstrates that alloying Cu and Zn can create active sites, in which Cu acts as an auxiliary active site further facilitating *CO generation.
Light‐Assisted Polyproton Dissociated PAAm‐PA Hydrogel‐Based Moisture‐Driven Electricity Generator with a Broad Operating Range
Authors: Cheng Yan , Yang Cheng , Zhu Tianxue , Wu Che , Huang Jianying , Lai Yuekun 
Published: October 2024

AbstractDue to its widespread availability and spontaneity, moisture electricity generation (MEG) holds unique advantages in self‐powered systems. However, it faces challenges, including the limitations of relying on a single kind of power generation and insufficient output performance. Inspired by the mechanisms of water absorption of plants, this paper explores a light‐moisture coordinated electricity generating hydrogel (L‐MEGH) device with flexible, scalable, and highly efficient energy conversion performance, which is obtained through the UV polymerization of hydrophilic acrylamide (AAM) and phytic acid (PA) in the presence of photosensitizers. The obtained hydrogel demonstrates superior moisture absorption and remarkable electricity generation stability across a range of humidity conditions. Notably, the open‐circuit voltage (Voc) of the L‐MEGH increased from 0.675 to 0.838 V after the addition of photosensitizers (Erythrosin B, E) (the significant enhancement, up to 24%), and the short‐circuit current (Isc) reaching 635.543 µA. This L‐MEGH can realize stable electrical output even under extreme temperatures, producing 0.5 V at −20 °C for 45 h. The scalable L‐MEGHs (connected on‐demand in series/parallel) can power various commercial electronics, including nighttime illumination, mobile phones, and health monitoring sensors. This work pioneers a sustainable power generation pathway capable of enhancing performance through the hybrid collection of multiple natural energy sources.
Engineering Nanoclusters of Cell Adhesive Ligands on Biomaterial Surfaces: Superior Cell Proliferation and Myotube Formation for Skeletal Muscle Tissue Regeneration
Authors: Nour Shirin , Shabani Sadegh , Swiderski Kristy , Lynch Gordon S. , O'Connor Andrea J. , Qiao Greg , Heath Daniel E. 
Published: October 2024

AbstractEngineering biointerfaces with nanoscale clustering of integrin‐binding cell adhesive peptides is critical for promoting receptor redistribution into signaling complexes. Skeletal muscle cells are exquisitely sensitive to integrin‐mediated signaling, yet biomaterials supporting myogenesis through control of the density and nanodistribution of ligands have not been developed. Here, materials are developed with tailorable cell adhesive ligands distribution at the interface by independently controlling their global and local density to enhance myogenesis, by promoting myoblast growth and myotube formation. To this end, RGD‐functionalized low‐fouling polymer surfaces with global ligand densities (G) from 0–7 µg peptide/mg polymer and average local ligand densities (L) from 1–6.3 ligands/cluster, are generated and characterized. Cell studies demonstrate improvements in cell adhesion, spreading, growth, and myotube formation up to a density of 7 µg peptide/mg polymer with 4 ligands/cluster. Optimizing ligand density and distribution also promotes early myofiber maturation, identified by increased MF20 marker protein expression and sarcomere‐forming myotubes. At higher ligand densities, these cell properties are decreased, indicating that ligand multivalency is a critical parameter for tailoring cell‐material interactions, to a certain threshold. The findings provide new insights for designing next‐generation biomaterials and hold promise for improved engineering of skeletal muscle.