bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing cross‐scale Raman in‐line monitoring capability of cell culture process in large‐scale manufacturing
Authors: Lang Zhe , Chen Gong , Yan Shaofan , Zhang Zhijun , Yang Yang , Tang Ziran , Zhu Huilin , Dong Shuhao , Zhou Hang , Zhou Weichang 
Published: September 2024

AbstractThis study introduces an approach to enhance the Raman calibration model cross‐scale prediction capabilities in cell cultures. Our investigation centers on the improvement of Raman calibration models along with the scaling‐up of mammalian cell culture processes. Initially, we observed that integrating data from a 50 L run into the original dataset at lab‐scale was an effective strategy for improving prediction accuracy on 1000 L run. Further investigation indicated that this improvement could be attributed to the similarity between the spectra of 50 L with 1000 L. Subsequent investigation unveiled that the spectral variations primarily stemmed from differences between the instruments. This was verified through a direct comparison of two Raman analyzers. Then two pairwise spectral transformation methods, direct standardization (DS) and piecewise DS, both exhibited superior performance in predicting. This research underscores the importance of Raman spectral transfer method to alleviate instrument‐to‐instrument variations in cross‐scale monitoring of cell culture processes.
Epidemiological Consequences of Individual Centrality on Wild Chimpanzees
Authors: Pierron Maxime , Sueur Cédric , Shimada Masaki , MacIntosh Andrew J. J. , Romano Valéria 
Published: September 2024

ABSTRACTDisease outbreaks are one of the key threats to great apes and other wildlife. Because the spread of some pathogens (e.g., respiratory viruses, sexually transmitted diseases, ectoparasites) are mediated by social interactions, there is a growing interest in understanding how social networks predict the chain of pathogen transmission. In this study, we built a party network from wild chimpanzees (Pan troglodytes), and used agent‐based modeling to test: (i) whether individual attributes (sex, age) predict individual centrality (i.e., whether it is more or less socially connected); (ii) whether individual centrality affects an individual's role in the chain of pathogen transmission; and, (iii) whether the basic reproduction number (R0) and infectious period modulate the influence of centrality on pathogen transmission. We show that sex and age predict individual centrality, with older males presenting many (degree centrality) and strong (strength centrality) relationships. As expected, males are more central than females within their network, and their centrality determines their probability of getting infected during simulated outbreaks. We then demonstrate that direct measures of social interaction (strength centrality), as well as eigenvector centrality, strongly predict disease dynamics in the chimpanzee community. Finally, we show that this predictive power depends on the pathogen's R0 and infectious period: individual centrality was most predictive in simulations with the most transmissible pathogens and long‐lasting diseases. These findings highlight the importance of considering animal social networks when investigating disease outbreaks.
Application Value and Safety Analysis of Warfarin, Rivaroxaban, and Dabigatran Ester in Elderly Patients With Atrial Fibrillation
Authors: Chen Cheng , Tian Qing , Cheng Chong , Ji Xixin , Feng Mengyun , Tan Huiqun , Zhou Qian 
Published: September 2024

ABSTRACTBackgroundThis study aimed to evaluate the application value and safety of Warfarin, Rivaroxaban, and Dabigatran in elderly patients with atrial fibrillation.MethodsA total of 180 elderly patients with atrial fibrillation admitted to our hospital were retrospectively analyzed. According to their anticoagulant treatment regimen, patients were divided into three groups: Warfarin (57 cases), Rivaroxaban (61 cases), and Dabigatran (62 cases). General demographic information was collected, and coagulation function indicators—including fibrinogen (FIB), thrombin time (PT), activated partial thrombin time (APTT), and D‐dimer (D‐D)—as well as liver function indexes—including total bilirubin (TbiL), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine transferase (ALT)—were compared before and after 4 weeks of treatment.ResultsThere were no significant differences in demographic characteristics such as gender, age, body mass index, or disease course among the three groups. The total effective rate in the Warfarin group (84.21%) was significantly lower than in the Rivaroxaban (98.36%) and Dabigatran (96.77%) groups (p < 0.05). However, there was no significant difference in the total effective rate between the Rivaroxaban and Dabigatran groups (p > 0.05). Additionally, no significant differences were found in the effects of the three drugs on coagulation function, liver function, or the incidence of bleeding (p = 0.052).ConclusionWarfarin, Rivaroxaban, and Dabigatran can effectively prevent thrombosis in elderly patients with atrial fibrillation, with Rivaroxaban and Dabigatran showing superior effectiveness. All three drugs demonstrated similar low rates of bleeding events and had no significant impact on coagulation and liver function.
Exploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity
Authors: Grilo Carlos M. , Pittman Brian 
Published: September 2024

ABSTRACTObjectiveTo explore dietary‐restraint as a mediator of binge eating and weight‐loss outcomes within a randomized controlled trial comparing cognitive‐behavioral therapy (CBT) and behavioral weight loss (BWL) for binge‐eating disorder (BED) with obesity.MethodsNinety participants were randomly assigned to CBT or BWL and assessed by evaluators blinded to conditions at pretreatment, throughout‐, and post‐treatment (6 months). Three dietary‐restraint measures (Eating Disorder Examination‐Questionnaire [EDE‐Q]‐Restraint, Three‐Factor Flexible‐Restraint and Rigid‐Restraint) were administered at pretreatment and after 2 months of treatment. Regression models examined whether changes at 2‐months in the restraint scales mediated the effects of treatment (CBT versus BWL) on binge eating and weight‐loss outcomes at post‐treatment.ResultsCBT and BWL had similar binge‐eating outcomes and similar changes in EDE‐Q‐restraint and flexible‐restraint. BWL had greater 2‐month increases in rigid‐restraint and greater weight‐loss at posttreatment than CBT, with results suggesting 2‐month changes in rigid‐restraint mediated the greater difference (>7 pounds) in weight‐loss. The observed mediation effect of 2.92 suggests 39% of total treatment‐effect on weight‐loss was mediated through 2‐month increases in rigid‐restraint.DiscussionThis secondary analysis within a trial comparing CBT and BWL for BED suggests early‐change in rigid‐restraint has a mediating effect of BWL on weight‐loss. Findings indicate that BWL improves binge eating and challenge views that dietary‐restraint might exacerbate binge eating in BED with obesity. Findings require confirmation using hypothesis‐testing in future trials.Trial Registration: Clinicaltrials.gov: NCT00537758 (“Treatment for Obesity and Binge Eating Disorder”)
Anthropogenic disturbance and competitive avoidance shape the coexistence pattern of macaque species in tropical forests
Authors: He Ru‐Chuan , Wang Lin , Hughes Alice C. , Geng Ying , Cao Hui , Liu Ying , Li Jia‐Bin , Wang Qiao‐Yan , Yang Zheng‐Bin , Quan Rui‐Chang 
Published: September 2024

AbstractThe factors that enable the coexistence of closely related species remain a major question in ecology, particularly in human‐disturbed habitats. The effects of anthropogenic disturbance and interspecific competition can exacerbate the decline in populations of competing species. The adoption of different strategies in responding to anthropogenic disturbances and competitive avoidances may create opportunities for competing species to coexist. However, few studies have explored how disturbance and competition interact to shape species coexistence. In this study, we conducted long‐term and large‐scale camera trap surveys comprising 540 sampling sites from 2017 to 2021 at Xishuangbanna, southwestern China, and deployed a spatiotemporal analysis framework to determine the effect of anthropogenic disturbances and competitive avoidances on the coexistence of three sympatric macaque species: Assamese macaque (Macaca assamensis; MA), northern pig‐tailed macaque (M. leonina; ML), and rhesus macaque (M. mulatta; MM). Macaque species exhibited diverse responses to different types of anthropogenic disturbances. The occurrence probability of MM was positively associated with distance to road and relative abundance of human occurrence, and negatively associated with distance to cropland, which reduces the likelihood of sympatry between MM and the other two species due to their opposing responses to road, cropland, and human occurrence. Conversely, the similar responses to road and cropland increase the sympatry between MA and ML. Three macaque species did not avoid each other through shifting space use or their overall daily activity pattern. However, they delayed using the shared site after other species used it to avoid confrontation. We provide evidence that (1) the spatial co‐occurrence pattern of sympatric macaque species was determined by anthropogenic disturbances rather than by competitive spatial avoidance and (2) fine‐scale temporary avoidance is the strategy to alleviate their interspecific competition. These results enhance our understanding of the underlying mechanisms leading to species coexistence of nonhuman primates in human‐disturbed habitats.
Efficient Synthesis of 2‐Arylpropionitriles Via Selective Monomethylation of Aryl Acetonitriles Using an Easy to Handle Methylation Agent
Authors: Papaplioura Eleni , Templ Johanna , Wildhack Nina , Schnürch Michael 
Published: September 2024

AbstractA convenient and safe methylation protocol employing quaternary ammonium salts (PhMe3NI) as alternative methylating agents for the selective α‐methylation of arylacetonitriles is presented. This approach allows for the selective α‐methylation of arylacetonitriles, overcoming the limitations of existing techniques, while offering a practical and sustainable solution for late‐stage functionalization in medicinal chemistry. The straightforward and safe nature of this methodology makes it particularly well‐suited for applications in drug discovery. In our report, we present a diverse set of 18 examples, achieving yields of up to 76 %.
The implications of frailty in older adults with epilepsy
Authors: Hashmi Syeda Amrah , Sachdeva Seerat , Sindhu Udeept , Tsai Carolyn , Bonda Kalyanchakradhar , Keezer Mark , Zawar Ifrah , Punia Vineet 
Published: September 2024

AbstractOlder adults constitute a large proportion of people with epilepsy (PWE) due to the changing demographics worldwide and epilepsy's natural history. Aging‐related pathophysiological changes lower the tolerance and increase our vulnerability to stressors, which manifests as frailty. Frailty is closely associated with adverse health outcomes. This narrative review examines the interplay between frailty and epilepsy, especially in older adults, emphasizing its clinical implications, including its role in managing PWE. Mechanistically, frailty develops through complex interactions among molecular and cellular damage, including genomic instability, mitochondrial dysfunction, and hormonal changes. These contribute to systemic muscle mass, bone density, and organ function decline. The concept of frailty has evolved from a primarily physical syndrome to include social, psychological, and cognitive dimensions. The “phenotypic frailty” model, which focuses on physical performance, and the “deficit accumulation” model, which quantifies health deficits, provide frameworks for understanding and assessing frailty. PWE are potentially more prone to developing frailty due to a higher prevalence of risk factors predisposing to frailty. These include, but are not limited to, polypharmacy, higher comorbidity, low exercise level, social isolation, low vitamin D, and osteoporosis. We lack commercial biomarkers to measure frailty but can diagnose it using self‐ or healthcare provider‐administered frailty scales. Recent attempts to develop a PWE‐specific frailty scale are promising. Unlike chronological age, frailty is reversible, so its management using multidisciplinary care teams should be strongly considered. Frailty can affect antiseizure medication (ASM) tolerance secondary to its impact on pharmacokinetics and pharmacodynamics. While frailty's effect on seizure control efficacy of ASM is poorly understood, its undoubted association with overall poor outcomes, including epilepsy surgery, behooves us to consider its presence and implication while treating older PWE. Incorporation of frailty measures in future research is essential to improve our understanding of frailty's role in PWE health.Plain Language SummaryFrailty is the declining state of the human body. People with epilepsy are more prone to it. It should be factored into their management.
Research on the risk spillover effect of carbon emission trading market and various industry markets in China and the European Union
Authors: Cui Hua , Fan Yixin , Li Juchao 
Published: September 2024

AbstractWidely concerns over the carbon emission problems have been aroused. Prior studies have documented the correlation between the carbon emission market and industries separately. This study compared the tail risks and risk spillover effect of the carbon emission and 11 industries markets in China and the European Union (EU) by using the multivariate multi‐quartile conditional autoregressive at‐risk model. Moreover, to evaluate the risk spillover of each market under extreme risk conditions in time domain and frequency domain, DY spillover index and BK spillover index were constructed via generalized forecast error variance decomposition and generalized causation spectrum, respectively. Findings are as follows: (1) The tail risks and fluctuation of the trend of Chinese industry markets reflects more higher and larger than those in the EU; (2) The EU suffers from smaller external shocks, while China has the opposite result and can recover relatively faster; (3) In China, energy, industrial, information technology, financial, real estate, consumer goods, carbon emissions, and discretionary consumption industries are risk spillover industries, while healthcare, materials, telecommunication services, and utilities industries are risk receiving industries. In contrast, the risk spillover industries in the EU remain consistent with those of the Chinese markets except for the materials, discretionary consumption, consumer goods, information technology and real estate industries. (4) On the short‐term, medium‐term and long‐term scales, the risk spillover of China's carbon emission trading market and various industries is basically consistent with that of the EU. These findings contribute to reducing greenhouse gas emissions and achieving the goal of carbon peak and carbon neutrality.
Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review
Authors: Nashwan Abdulqadir J. , Abuawwad Mohammad T. , Jaradat Jaber H. , Ibraheem Anas , Yassin Mohamed A. , Taha Mohammad J. J. 
Published: September 2024

AbstractBackground and AimsChronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. This scoping review aimed to study the prevalence and implications of iron overload in CKD patients undergoing PD.MethodsA comprehensive search was conducted across five databases, leading to the selection of 18 papers for in‐depth analysis. These studies collectively involved 381 PD patients, 60.3% were males.ResultsNo consensus was reached regarding the exact diagnostic cutoff for iron overload. The investigations revealed four main aspects: (1) Seven papers identified various factors contributing to iron overload, emphasizing the role of different iron supplements and magnetic resonance imaging's capability to diagnose iron accumulation in organs; (2) Iron overload in young patients was found to hinder growth; (3) Six studies highlighted the adverse effects of iron overload, with cardiac issues being the most significant; (4) Three studies demonstrated the efficacy of iron‐chelating agents, Deferoxamine and Deferasirox, in treating iron overload patients undergoing PD. Overall, the estimated prevalence of liver iron overload in CKD patients on PD ranges from approximately 10% to 28.6%, which is far lower than the prevalence of 75% elegantly shown in HD patients.ConclusionWhile iron overload was a significant concern for CKD patients undergoing PD in the past, it is less common in the current era due to advancements in treatments, such as erythropoiesis‐stimulating agents. Treatment with specific chelation agents has proven beneficial, but there is also a risk of adverse effects, necessitating meticulous monitoring and timely intervention.
Major impacts of the US Renewable Fuel Standard on corn and soybean cultivation
Authors: Smith T. Jake , Moschini GianCarlo 
Published: September 2024

AbstractWe use rich spatial data on observed crop choices and ethanol production to estimate the local impacts of ethanol plants and the overall impact of the 2007 US Renewable Fuel Standard (the RFS2) on crop patterns. We find that the RFS2 increased total corn area by 9.7%, corn monoculture by 16.8%, and soybean area by 6.7%, with notable spatial heterogeneity in both the overall impact and the local effects of ethanol plants. The results indicate an RFS2‐induced shift in the geography of corn and soybean cultivation within the Corn Belt—intensification in the core, and significant expansion near the periphery.
Microplastics and nanoplastics in soil: Sources, impacts, and solutions for soil health and environmental sustainability
Authors: Nath Soumitra , Enerijiofi Kingsley Erhons , Astapati Ashim Das , Guha Anupam 
Published: September 2024

AbstractThe present review discusses the growing concern of microplastics (MPs) and nanoplastics (NPs) in soil, together with their sources, concentration, distribution, and impact on soil microorganisms, human health, and ecosystems. MPs and NPs can enter the soil through various pathways, such as agricultural activities, sewage sludge application, and atmospheric deposition. Once in the soil, they can accumulate in the upper layers and affect soil structure, water retention, and nutrient availability. The presence of MPs and NPs in soil can also have ecological consequences, acting as carriers for pollutants and contaminants, such as heavy metals and persistent organic pollutants. Additionally, the leaching of chemicals and additives from MPs and NPs can pose public health risks through the food web and groundwater contamination. The detection and analyses of MPs and NPs in soil can be challenging, and methods involve spectroscopic and microscopy techniques, such as Fourier‐transform infrared spectroscopy and scanning electron microscopy. To mitigate the presence and effects of MPs and NPs in soil, it is essential to reduce plastic waste production, improve waste management practices, and adopt sustainable agricultural practices. Effective mitigation measures include implementing stricter regulations on plastic use, promoting biodegradable alternatives, and enhancing recycling infrastructure. Additionally, soil amendments, such as biochar and compost, can help immobilize MPs and NPs, reducing their mobility and bioavailability. This review article aims to provide a comprehensive understanding of these emerging environmental issues and identify potential solutions to alleviate their impact on soil health, ecosystem functioning, and community health.
Radiation therapists' perceptions of participating in Professional Supervision – a pilot study
Authors: Dungey Gay , Thomson Sarah , Lopez Paula Rodriguez 
Published: September 2024

AbstractIntroductionProfessional Supervision (PS) is a common approach used to reduce the fallout from stress and burnout. It involves monthly face‐to‐face meetings between a supervisor and supervisee to address well‐being and professional goals. This pilot study examines 12 radiation therapists (RTs) perceptions of participating in PS.MethodsConducted in the Christchurch Radiation Oncology Centre, this mixed‐methods pilot study introduced PS in March 2022. In August 2023, 12 RTs completed a QUALTRICS online questionnaire consisting of 33 questions, including the Supervisor Working Alliance Inventory (SWAI). The SWAI assessed the alliance of supervision from a supervisee's perspective and comprised of 19 questions on a 7‐point Likert scale and nine yes/no statements with optional comments. Five demographic questions were also included.ResultsAll 12 RTs completed the questionnaire, with quantitative results indicating a positive alliance between supervisors and supervisees. RTs found PS to be a safe and comfortable space for reflective practice and support. Thematic analysis of qualitative data from additional comments revealed PS enabled RTs to reflect on career achievements, appreciate highlights of being an RT and consider future career paths within the profession.ConclusionsRadiation therapists responded positively to PS, suggesting its potential in managing workplace stressors, promoting career advancement and providing dedicated time for reflection, support and guidance. RTs endorsed the efficacy of PS in enhancing their practice and advocated for its widespread adoption among RTs.
Fermentation starters and bacteriocins as biocontrol strategies for table olives preservation: a mini‐review
Authors: Rus‐Fernández Patricia , Fuentes Ana 
Published: September 2024

AbstractBiopreservation is a powerful strategy to prolong the shelf life of food products by applying naturally occurring microorganisms and/or their metabolites. Current food trends emphasise the need to develop alternatives for chemical or thermal preservation methods. In this line, different fermentation starters from table olives present the potential to control spoilage or pathogen‐occurring microorganism in table olives storage. One of the most interesting family used as biopreservative culture is Lactobacillaceae and it has also been used in combination with yeasts as olive fermentation starter. Lactic acid bacteria, from Lactobacillaceae family, are characterised by the production of bacteriocins, proteins with the potential for preserving food by changing the organisation of the membrane of spoilage microorganisms. These bacteriocins‐producing bacteria can be directly inoculated, although nanosystem technology is the most promising incorporation strategy. In table olives, the most commonly used starters are Lactiplantibacillus plantarum, Lactiplantibacillus pentosus, Saccharomyces cerevisiae, Wickerhamomyces anomalus, among others. These strains with biopreservation characteristics, inoculated alone or in mixed cultures, ensure food safety by conferring the product added value and prolonging product shelf life. © 2024 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.