bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic profiling of type 1 diabetes mellitus in children and adolescents: a case–control study
Authors: Bervoets Liene , Massa Guy , Guedens Wanda , Louis Evelyne , Noben Jean-Paul , Adriaensens Peter 
Published: June 2017

AbstractBackgroundType 1 diabetes mellitus (T1DM) is one of the most common pediatric diseases and its incidence is rising in many countries. Recently, it has been shown that metabolites other than glucose play an important role in insulin deficiency and the development of diabetes. The aim of our study was to look for discriminating variation in the concentrations of small-molecule metabolites in the plasma of T1DM children as compared to non-diabetic matched controls using proton nuclear magnetic resonance (1H-NMR)-based metabolomics.MethodsA cross-sectional study was set-up to examine the metabolic profile in fasting plasma samples from seven children with poorly controlled T1DM and seven non-diabetic controls aged 8–18 years, and matched for gender, age and BMI-SDS. The obtained plasma1H-NMR spectra were rationally divided into 110 integration regions, representing the metabolic phenotype. These integration regions reflect the relative metabolite concentrations and were used as statistical variables to construct (train) a classification model in discriminating between T1DM patients and controls.ResultsThe total amount of variation explained by the model between the groups is 81.0% [R2Y(cum)] and within the groups is 75.8% [R2X(cum)]. The predictive ability of the model [Q2(cum)] obtained by cross-validation is 50.7%, indicating that the discrimination between the groups on the basis of the metabolic phenotype is valid. Besides the expected higher concentration of glucose, the relative concentrations of lipids (triglycerides, phospholipids and cholinated phospholipids) are clearly lower in the plasma of T1DM patients as compared to controls. Also the concentrations of the amino acids serine, tryptophan and cysteine are slightly decreased.ConclusionsThe present study demonstrates that metabolic profiling of plasma by1H-NMR spectroscopy allows to discriminate between T1DM patients and controls. The metabolites that significantly differ between both groups might point to disturbances in biochemical pathways including (1) choline deficiency, (2) increased gluconeogenesis, and (3) glomerular hyperfiltration. Although the sample size of this study is still somewhat limited and a validation should be performed, the proof of principle looks promising and justifies a deeper investigation of the diagnostic possibilities of1H-NMR metabolomics in follow-up studies.Trial registrationNCT03014908. Registered 06/01/2017. Retrospectively registered
La política exterior argentina y su vinculación con los condicionamientos internos en el siglo XXI
Authors: Miguez María Cecilia 
Published: June 2017

Los gobiernos de Néstor Kirchner y Cristina Fernández se destacaron por su creciente alejamiento de los Estados Unidos, su acercamiento a países de la región sudamericana y la apuesta por un nuevo orden regional, la profundización de los vínculos con China y con Rusia, la participación de alto perfil en diversos foros internacionales y la insistencia en el reclamo por la soberanía de las Islas Malvinas. Este artículo desarrolla las características de esa política internacional. Tiene como objetivo describir la política exterior de los gobiernos del Frente para la Victoria que se sucedieron entre 2003 y 2015, con la intención de inscribir dicha política en el marco de una serie de transformaciones económicas y políticas internas. Pretende entender la política exterior desde un enfoque histórico que permita relacionarlacon tensiones y debates en el seno de la sociedad civil y, por lo tanto, con expresión en el Estado.
Physiological effects of proinsulin-connecting peptide in human subcutaneous adipose tissue
Authors: Ghorbani A , Shafiee-Nick R , Zojaji SA , Rajabi-Mashhadi MT 
Published: June 2017

Recent studies suggest that proinsulin-connecting peptide (C-peptide) may exhibit characteristics of a hormone and show physiological functions in various tissues. This study was aimed to determine whether C-peptide could be involved in the regulation of lipolysis, adiponectin release, and function of mesenchymal stem cells (MSCs) in adipose tissue. Human subcutaneous adipose tissue was cultured in the presence of C-peptide. The level of lipolysis was determined by glycerol measurement in the conditioned media. Effect of C-peptide on adiponectin secretion was evaluated in differentiated adipocytes. The adipogenic and osteogenic abilities of adipose MSCs were evaluated using oil red and alizarin red staining, respectively. The tetrazolium bromide test was conducted for evaluating the effect of C-peptide on MSCs proliferation. C-peptide induced a significant decrease in basal lipolysis at concentrations of 8 and 16 nM (p < 0.05). It had no significant effects on isoproterenol-stimulated lipolysis, adiponectin secretion, and adipogenic or osteogenic differentiation of MSCs. At a concentration of 4 nM, this peptide significantly increased the proliferative capability of MSCs (p < 0.05). These results suggest that C-peptide has some physiological effects in human subcutaneous adipose tissue and contributes to the regulation of basal lipolysis and pool of MSCs.
NEURODYNAMIC MOBILIZATION REDUCES INTRANEURAL FIBROSIS AFTER SCIATIC CRUSH LESION IN RATS
Authors: Lima Êmyle Martins , Santana Herman Henrique Silva , Medrado Alena Peixoto , Martinez Ana Maria Blanco , Baptista Abrahão Fontes 
Published: June 2017

Peripheral nerve lesions may be associated with abnormal scarring that lead to regenerative failure and dysfunction. Neurodynamic mobilization (NM) imposes controlled mechanical loads on the peripheral nerve and may influence inflammation and collagen deposition after a lesion. However, there is lack of experimental data to support these claims. Objective: To evaluate the impact of NM in the intraneural number of mast cells, collagen deposition and number of blood vessels after an ischiatic crush lesion in rats. Methods: This is a laboratory animal study, where 20 rats (Rattus norvegicus) were randomly divided into two groups, NM (n=10) and control (n=10), submitted to a right ischiatic nerve lesion. A tensioning NM began 10 days after lesion, and was maintained once a day, six times a week, for three weeks. After this period, the animals were euthanized and the nerves assessed for the number of mast cells, collagen area and number of blood vessels. Results: NM led to a lower number of degranulated mast cells (Kruskal-Wallis=0.29 p<0.05), organization of collagen deposition (Kruskal-Wallis = 0.01, p<0.05 ). There was no influence of NM on the number of intraneural blood vessels (Kruskal-Wallis=0.46 p<0.05). Conclusion: NM started 10 days after a ischiatic nerve crush lesion modulates the inflammatory process and prevents random deposition of collagen at the lesion site, but has no influence on blood vessels formation.
Spinal cord stimulation in the treatment of neuropathic pain: Current perspectives of indications, cost-effectiveness, complications and results
Authors: Camporeze Bruno , Simm Renata Faria , Estevão Iracema Araújo , Junior Luis Roberto Mathias , Aguiar Paulo Henrique Pires de , Carrondo-Cottin Sylvine 
Published: June 2017

Introduction: The spinal cord stimulation (SCS) has been described as a valuable neuromodulating procedure in the management of chronic and medically untreated neuropathic pain. Although, many studies have discussed the use of this technique, a question still remains regarding its efficacy in different medical conditions with different etiology in the long term. The aim of this paper is to discuss the risks, complications, cost-effectiveness and results of SCS in patients affected by chronic neuropathic pain based on the comprehensive literature review.
Methods: Bibliographic search of references from 1950 to 2016 using the databases MEDLINE, LILACS, SciELO, PubMed, and applied language as selection criteria, choosing preferably recent articles written in Portuguese, Spanish or English.
Results: Based on literature review, SCS is a safe, reversible, adjustable and nondestructive surgical procedure demonstrating a significant effect in the reduction of pain intensity and improvement in quality of life in these patients. Furthermore, in spite of the initial high cost to its application, SCS has been associated with lower rates of complications and high rates of cost-effectiveness when compared to standard therapies.
Conclusion: Although used in medical conditions with different etiology, the procedure is still an effective and a cost-effective approach to neuropathic pain, mainly in patients affected by failed back pain syndrome (FBSS) and complex regional pain syndrome (CRPS).
Os multiletramentos na aprendizagem de línguas por estudantes de licenciatura em Letras-Inglês / Multiliteracies in the learning of languages in an English language degree course
Authors: Ferraz Daniel de Mello , Nogarol Isabele Vianna 
Published: June 2017

RESUMO:Segundo Rojo (2012, p. 15), o conceito de multiletramentos aponta para “a multiplicidade cultural das populações e a multiplicidade semiótica de constituição dos textos por meio dos quais ela se informa e se comunica”. Nesse sentido, percebemos que a maioria dos estudantes de Letras-Inglês da UFES inicia a graduação com excelente nível linguístico na língua inglesa (LI) e que, muitos deles, aprimoraram suas habilidades linguísticas por meio da multimodalidade presente nas músicas on-line, jogos virtuais, websites e aplicativos. Segundo Zacchi e Wielewicki (2015), essas ferramentas digitais são oportunidades para aprender conteúdos diversos de forma mais lúdica. Esta pesquisa se justifica na medida em que busca revisitar o que significa ensinar e aprender uma língua estrangeira em tempos contemporâneos, trazendo, dessa forma, temas transdisciplinares (multiletramentos) para a discussão sobre o ensino e a aprendizagem de LI. Assim, esta pesquisa, qualitativa, com coleta de dados por meio de entrevistas, questionários e observação de aulas, busca entender como e por quais meios a aprendizagem de inglês ocorre e de que maneira os multiletramentos vêm sendo abordados no curso de Letras-Inglês de uma universidade federal brasileira. ABSTRACT:According to Rojo (2012, p. 15), the concept of multiliteracies focuses on “the cultural diversity of the peoples and the semiotic multiplicity regarding the creation of texts by means of which it informs and communicates". In this sense, it is observed that most English language undergraduate students from the Federal University of Espírito Santo start their undergraduate courses with excellent linguistic levels in English, also, that many of them have improved their language skills through the multimodality in music, virtual games, websites and applications. According to Zacchi and Wielewicki (2015), these digital tools are opportunities for learning diverse contents in a more playful way. The aim of this research is to revisit what it means to teach and learn a foreign language in contemporary times, bringing thus transdisciplinary themes (mutiliteracies) to the discussion about the teaching and learning of the English language. With that aim, a qualitative research endeavor was carried out with data collection involving interviews, questionnaires and classroom observation. We seek to understand how and by what means the English learning occurs, and how the theme of multiliteracies has been approached in an English Language teaching course of a Brazilian Federal University.
Análise da produção da escrita e do discurso do surdo no Facebook / Analysis of the written production and the speech of the deaf on Facebook
Authors: Waris Franciany Chaves 
Published: June 2017

RESUMO: O presente estudo faz uma análise de como se configura a produção da escrita e do discurso do surdo na rede social Facebook, a fim de compreender os processos linguísticos envolvidos nesse contexto. Especificamente, descreve-se a relação entre o texto escrito em Língua Portuguesa e o discurso produzido pelo surdo e se analisa se a organização da escrita implica a compreensão do discurso produzido. Para tanto, realiza-se um estudo qualitativo de cunho bibliográfico baseado em autores como Severino (2007), Lakatos e Marconi (2001) e Gil (2002), composto por três etapas, e faz-se a análise dos discursos produzidos a partir da Semântica Global proposta por Maingueneau (2008). Os resultados revelaram que o surdo considera fatores pertinentes ao contexto social em que ele está inserido, pois enuncia o fruto de sua interação com o mundo. Constata-se, nos enunciados produzidos, que elementos linguísticos como o tempo e a intencionalidade discursiva são utilizados e, ainda, a referência a outras obras e fatos exteriores. Conclui-se que a estrutura gramatical dos enunciados não compromete a compreensão do discurso do surdo, tampouco é fator delimitante da aquisição da segunda língua. ABSTRACT:The present study does an analysis of the written production and speech of the deaf on the social network Facebook, aiming at understanding the linguistic processes involved in this context. Specifically, it is attempted to describe the relationship between the written text in Portuguese language and the speech produced by the deaf, and evaluate whether the writing system implies the understanding of the produced speech. Therefore, a qualitative study of bibliographical nature was performed, based on authors like Severino (2007), Lakatos and Marconi (2001), and Gil (2002), consisting of three stages. The analyses of the speech produced were accomplished considering the Global Semantic proposed by Maingueneau (2008). The results showed that the deaf considers relevant factors of the social context in which they are inserted, because they speech their interaction with the world. It was observed in the produced utterances that linguistic elements such as time and discursive were intentionality used, and also reference to other works and external facts. It was concluded that the grammatical structure of utterances does not compromise the understanding of deaf’s speech, neither it is a limiting factor of the second language acquisition.
A regulamentação do canabidiol no Brasil: como nasce a expertise leiga | Cannabidiol regulation in Brazil: how lay expertise is born
Authors: Oliveira Monique Batista 
Published: June 2017

RESUMO Esse artigo mostra como o processo de regulamentação do canabidiol no Brasil possibilitou o desenvolvimento de uma expertise leiga com influência em instituições e políticas públicas. O canabidiol é um dos compostos presentes na cannabis com potencial anticonvulsivo. O texto aponta similaridades desse ativismo com o da Aids nos 1990 a partir da análise de Steven Epstein. Credibilidade, capacidade de mobilização, domínio sobre a linguagem da ciência e autonomia estão entre os fatores que formam esse leigo diferenciado. O texto questiona, no entanto, se esse leigo é representativo de outros e se ele contribui para uma ciência mais democrática.Palavras-chave: Ciência Cidadã; Expertise Leiga; Maconha – Uso Terapêutico; Canabidiol – Uso Terapêutico; Regulamentação do Canabidiol.ABSTRACT This article shows how cannabidiol regulation in Brazil enabled the development of lay expertise with influence in public institutions and policies. Cannabidiol is a compound identified in cannabis, with anticonvulsant potential. The text points out similarities of this experience with that of Aids activists in the 1990’s based on Steven Epstein’s analysis. Credibility, mobilization, mastery over the language of science and autonomy are among the factors that produce this distinguished layman. This work inquires, however, if this layman is representative of others and if he contributes to a more democratic science. Keywords: Citizen Science; Lay Expertise; Marijuana – Therapeutic Use; Cannabidiol – TherapeuticUse; Canabidiol Regulation
Hackerspaces, ciência cidadã e ciência comum: apontamentos para uma articulação | Hackerspaces, citizen science and common science: some notes for an articulation
Authors: Martins Beatriz Cintra 
Published: June 2017

RESUMO Nas últimas décadas, temos assistido à proliferação de diversos tipos de espaços alternativos de pesquisa, produção e aprendizado colaborativos. Neste artigo, abordamos um tipo específico deles, os hackerspaces, que se caracterizam por serem, a princípio, auto-organizados e autofinanciados, sem patrocínio ou ingerência externa. Em nossa análise, além de explorar suas especificidades, trazemos alguns apontamentos a fim de articular essa experiência com as iniciativas de ciência cidadã, em sua vertente democrática, e a constituição de uma ciência comum, proposta por Antonio Lafuente e Adolfo Estalella.Palavras-chave: Hackerspace; Ciência Cidadã; Ciência Comum; Espaços Alternativos de Pesquisa; Produção e Aprendizado.ABSTRACT For the last decades, we have witnessed the proliferation of several kinds of alternative spaces of collaborative research, production and learning. In this article we address a specific one, the hackerspaces, which are characterized as being, theoretically, self-organized and self-financed, without external sponsorship or interference. In our analysis, besides exploring their specificities, we bring forward some notes, in order to articulate this experience with the citizen science initiatives, in its democratic bias, and the constitution of a common science, as proposed by Antonio Lafuente and Adolfo Estalella.Keywords: Hackerspace; Citizen Science; Common Science; Alternative Spaces of Research; Production and Learning.
COMUNIDADES NEGRAS RURAIS, EXPROPRIAÇÃO E SEGURANá‡A NACIONAL NO DOCUMENTáRIO ”TERRAS DE QUILOMBOS - UMA DáVIDA HISTÓRICA”
Authors: CHAVES LEONARDO LEAL 
Published: June 2017

TERRA de quilombos: uma dá­vida histórica. Direção: Murilo Santos. Produção: Rosenita Santos. Brasá­lia, DF: Associação Brasileira de Antropologia, 2003. 1 DVD (45 min), son., color.QUILOMBOLAS COMUNITIES, EXPROPRIATION AND NATIONAL SECURITY IN DOCUMENTARY FILM ”TERRAS DE QUILOMBOS - UMA DáVIDA HISTÓRICA” COMUNIDADES NEGRAS RURALES, EXPROPIACáON Y SEGURIDAD NACIONAL EN DOCUMENTARIO ”TERRAS DE QUILOMBOS - UMA DáVIDA HISTÓRICA”
Preparación de las nutriciones parenterales pediátricas
Authors: Gomis Muñoz Pilar 
Published: June 2017

Las nutriciones parenterales (NP) se deben preparar en cabina de flujo laminar horizontal. Es importante realizar controles microbiológicos periódicamente.La preparación de las NP está centralizada desde hace bastantes años en los Servicios de Farmacia. Las principales ventajas de esta centralización son garantizar unas condiciones de asepsia en la manipulación de sus componentes y validar la compatibilidad, estabilidad y adecuación de los requerimientos prescritos. La preparación de las NP se debe realizar en áreas de ambiente controlado con cabina de flujo laminar horizontal clase 100 cumpliendo estrictamente una normativa de trabajo que incluye la manera de preparar las NP y la limpieza del área y cabina. El proceso de elaboración debe garantizar el mantenimiento de las condiciones de asepsia en la manipulación para conseguir la esterilidad de las NP. Periódicamente hay que realizar controles microbiológicos y validar el proceso de preparación.
Experimental Study on Oil Removal in Nutshell Filters for Produced-Water Treatment
Authors: Rawlins C. H. , Sadeghi F.. 
Published: June 2017

Summary
Laboratory testing was conducted with a nutshell filter to determine the oil-removal performance on the basis of the flux rate, media type, media size, water salinity, and oil concentration. The goal was to determine the operating parameters that allowed &lt;5 parts per million by volume (ppmv) of oil at the outlet, which is the normal operating point for this technology in produced-water treatment.
Nutshell filters composed of black walnut or pecan granular media are an established produced water-treatment technology for tertiary oil removal. Guidelines for the size and operation of nutshell filters have evolved mainly by trial and error, with limited published operating data. This laboratory-research program tested a nutshell filter to determine the operating flux limits (flow rate per unit area) that provide suitable oil-removal performance. The separation-efficiency target was defined as 5 ppmv of oil in the outlet stream. The variables tested included medium type [black walnut shell (BWS) or pecan shell (PS)], medium size, filtration flux, water salinity, and oil concentration. The flux limit for common 12/20 media is 12.0 (gal/min)/ft2 (or gpm/ft2) for freshwater operation and 13.0 gpm/ft2 for saline water. Decreasing the medium size to 20/30 mesh increased the allowable flux limit but at the expense of a substantial increase in the pressure drop. Oil-droplet penetration into the filter bed proceeds by means of a near-plug-flow profile, with the top 18 in. of the bed providing 99% of the oil removal. Full breakthrough is a function of inlet concentration, with 20–30 hours of operation expected for a 48-in.-deep bed.
UTILIZAÇÃO DE SENSOR PORTÁTIL PARA RECOMENDAÇÃO DE ADUBAÇÃO NITROGENADA ASSOCIADA AO USO DE FUNGICIDAS EM ARROZ IRRIGADO
Authors: Santos Alberto Baêta dos , Santos Talita Pereira Baêta , Filippi Marta Cristina Corsi de , Alves Karina Dutra , Botelho Thiago Henrique Arbués , Caldas Pedro Paulo De Carvalho 
Published: June 2017

O objetivo do trabalho foi determinar a influência da presença ou ausência da aplicação de fungicidas, e dos manejos de nitrogênio, com base no uso do clorofilômetro e de acordo com a recomendação local, naprodutividade de grãos e nas características agronômicas das cultivares BRS Tropical e Epagri 109 de arroz irrigado, em várzea tropical. A pesquisa foi conduzida em um Gleissolo Háplico distrófico de várzea,por dois anos consecutivos. O delineamento experimental usado foi o de blocos casualizados, com quatro repetições, no esquema de parcelas divididas constituídas pelas aplicações de fungicidas, as subparcelas,pelas cultivares e, as subsubparcelas, pelos manejos de nitrogênio. A adubação nitrogenada com base no uso do clorofilômetro é realizada nos momentos de maior demanda do nutriente pelas plantas e, na ausência de fungicidas, propicia aumento na produtividade de grãos e na eficiência de uso de nitrogênio. Esse manejo de nitrogênio associado com a aplicação de fungicidas promove melhoria no perfilhamentoe no rendimento industrial de grãos. A necessidade da aplicação de fungicidas em arroz irrigado é maior quando a adubação nitrogenada em cobertura é efetuada tardiamente em épocas pré-determinadas deacordo com as recomendações tradicionais.
Palavra e conceito: a crítica de Giordano Bruno ao pedantismo
Authors: Dos Santos Willian Ricardo 
Published: June 2017

Em seus Diálogos Italianos Giordano Bruno (1548-1600) elabora uma forte crítica à tradição acadêmica de seu tempo, a qual estava atrelada a um exagerado uso de recursos linguísticos para tratar de problemas filosóficos. Neste artigo apresento um viés da crítica de Bruno aos humanistas aristotélicos de Oxford, os quais Bruno satiriza compondo a figura do pedante. O pedante é um conhecedor de línguas clássicas, que, contudo, é incapaz de pensar filosoficamente. Nosso objetivo é apresentar como que Bruno, apoiado em sua ontologia, desenvolve sua filosofia opondo-se ao pedante tanto no conteúdo filosófico quanto na forma expositiva.