bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: Germline BRCA mutation carriers and wild‐type BRCA pancreatic ductal adenocarcinoma
Authors: O'Reilly Eileen M. , Lee Jonathan W. , Lowery Maeve A. , Capanu Marinela , Stadler Zsofia K. , Moore Malcolm J. , Dhani Neesha , Kindler Hedy L. , Estrella Hayley , Maynard Hannah , Golan Talia , Segal Amiel , Salo‐Mullen Erin E. , Yu Kenneth H. , Epstein Andrew S. , Segal Michal , Brenner Robin , Do Richard K. , Chen Alice P. , Tang Laura H. , Kelsen David P. 
Published: January 2018

BACKGROUNDA phase 1 trial was used to evaluate a combination of cisplatin, gemcitabine, and escalating doses of veliparib in patients with untreated advanced pancreatic ductal adenocarcinoma (PDAC) in 2 cohorts: a germline BRCA1/2‐mutated (BRCA+) cohort and a wild‐type BRCA (BRCA–) cohort. The aims were to determine the safety, dose‐limiting toxicities (DLTs), maximum tolerated dose, and recommended phase 2 dose (RP2D) of veliparib combined with cisplatin and gemcitabine and to assess the antitumor efficacy (Response Evaluation Criteria in Solid Tumors, version 1.1) and overall survival.METHODSGemcitabine and cisplatin were dosed at 600 and 25 mg/m2, respectively, over 30 minutes on days 3 and 10 of a 21‐day cycle. Four dose levels of veliparib were evaluated: 20 (dose level 0), 40 (dose level 1), and 80 mg (dose level 2) given orally twice daily on days 1 to 12 and 80 mg given twice daily on days 1 to 21 (dose level 2A [DL2A]).RESULTSSeventeen patients were enrolled: 9 BRCA+ patients, 7 BRCA– patients, and 1 patient with an unknown status. DLTs were reached at DL2A (80 mg twice daily on days 1 to 21). Two of the 5 patients in this cohort (40%) experienced grade 4 neutropenia and thrombocytopenia. Two grade 5 events occurred on protocol. The objective response rate in the BRCA+ cohort was 7 of 9 (77.8%). The median overall survival for BRCA+ patients was 23.3 months (95% confidence interval [CI], 3.8‐30.2 months). The median overall survival for BRCA– patients was 11 months (95% CI, 1.5‐12.1 months).CONCLUSIONSThe RP2D of veliparib was 80 mg by mouth twice daily on days 1 to 12 in combination with cisplatin and gemcitabine; the DLT was myelosuppression. Substantial antitumor activity was seen in BRCA+ PDAC. A randomized phase 2 trial is currently evaluating cisplatin and gemcitabine with and without veliparib for BRCA+ PDAC (NCT01585805). Cancer 2018;124:1374‐82. © 2018 American Cancer Society.
Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics
Authors: Lledos Marina , Mirabello Vincenzo , Sarpaki Sophia , Ge Haobo , Smugowski Hubert J. , Carroll Laurence , Aboagye Eric O. , Aigbirhio Franklin I. , Botchway Stanley W. , Dilworth Jonathan R. , Calatayud David G. , Plucinski Pawel K. , Price Gareth J. , Pascu Sofia I. 
Published: January 2018

AbstractMolecular imaging has become a powerful technique in preclinical and clinical research aiming towards the diagnosis of many diseases. In this work, we address the synthetic challenges in achieving lab‐scale, batch‐to‐batch reproducible copper‐64‐ and gallium‐68‐radiolabelled metal nanoparticles (MNPs) for cellular imaging purposes. Composite NPs incorporating magnetic iron oxide cores with luminescent quantum dots were simultaneously encapsulated within a thin silica shell, yielding water‐dispersible, biocompatible and luminescent NPs. Scalable surface modification protocols to attach the radioisotopes 64Cu (t1/2=12.7 h) and 68Ga (t1/2=68 min) in high yields are reported, and are compatible with the time frame of radiolabelling. Confocal and fluorescence lifetime imaging studies confirm the uptake of the encapsulated imaging agents and their cytoplasmic localisation in prostate cancer (PC‐3) cells. Cellular viability assays show that the biocompatibility of the system is improved when the fluorophores are encapsulated within a silica shell. The functional and biocompatible SiO2 matrix represents an ideal platform for the incorporation of 64Cu and 68Ga radioisotopes with high radiolabelling incorporation.
Integrated Reporting Quality: An Empirical Analysis
Authors: Pistoni Anna , Songini Lucrezia , Bavagnoli Francesco 
Published: January 2018

AbstractIntegrated Reporting (IR) represents the most recent evolution of the corporate reporting movement. Despite the proposed benefits to stakeholders and the number of contributes aimed at identifying best practices in its adoption, IR is still scarcely diffused among companies and when it is adopted the framework is not fully implemented. Starting from these premises, this paper aims to assess the quality of integrated reports issued by firms. We have developed a scoring model and an IR Scoreboard (IRS), which were applied to analyze 116 integrated reports issued in years 2013 and 2014. The main findings show that IR quality is low. Generally, firms follow the IR framework, but scarce information is disclosed on aspects such as capital, the business model, strategic priorities, and the value creation process; more attention is given to the IR form than to its content. Copyright © 2018 John Wiley & Sons, Ltd and ERP Environment
Multidimensional trait space informed by a mechanistic model of tree growth and carbon allocation
Authors: Fell Michael , Barber Jarrett , Lichstein Jeremy W. , Ogle Kiona 
Published: January 2018

AbstractPlant functional traits research has revealed many interesting and important patterns among morphological, physiological, and life‐history traits and the environment. These are exemplified in trade‐offs between groups of traits such as those embodied in the leaf and wood economics spectra. Inferences from empirical studies are often constrained by the correlative nature of the analyses, availability of trait data, and a focus on easily measured traits. However, empirical studies have been fundamental to modeling endeavors aiming to enhance our understanding of how functional traits scale up to affect, for example, community dynamics and ecosystem productivity. Here, we take a complementary approach utilizing an individual‐based model of tree growth and mortality (the allometrically constrained growth and carbon allocation [ACGCA] model) to investigate the theoretical trait space (TTS) of North American trees. The model includes 32 parameters representing allometric, physiological, and anatomical traits, some overlapping leaf and wood economics spectra traits. Using a Bayesian approach, we fit theACGCAmodel to individual tree heights and diameters from theUSFSForest Inventory and Analysis (FIA) dataset, with further constraints by literature‐based priors. Fitting the model to 1.3 millionFIArecords—aggregated across individuals, species, and sites—produced a posterior distribution of traits leading to realistic growth. We explored this multidimensional posterior distribution (theTTS) to evaluate trait–trait relationships emerging from theACGCAmodel, and compare these against empirical patterns reported in the literature. Only three notable bivariate correlations, among 496 possible trait pairs, were contained in theTTS. However, stepwise regressions uncovered a complicated structure; only a subset of traits—related to photosynthesis (e.g., radiation‐use efficiency and maintenance respiration)—exhibited strong multivariate trade‐offs with each other, while half of the traits—mostly related to allometries and construction costs—varied independently of other traits. Interestingly, specific leaf area was related to several rarely measured root traits. The trade‐offs contained in theTTSgenerally reflect mass‐balance (related to carbon allocation) and engineering (mostly related to allometries) trade‐offs represented in theACGCAmodel and point to potentially important traits that are under‐explored in field studies (e.g., root traits and branch senescence rates).
Electrochemical Behaviour of Microwave‐assisted Oxidized MWCNTs Based Disposable Electrodes: Proposal of a NADH Electrochemical Sensor
Authors: Blandón‐Naranjo Lucas , Della Pelle Flavio , Vázquez Mario V. , Gallego Jaime , Santamaría Alexander , Alzate‐Tobón Manuela , Compagnone Dario 
Published: January 2018

AbstractThe effect of the oxidation degree of multiwalled carbon nanotubes (MWCNTs) for the detection of NADH was evaluated in this paper. MWCNTs were oxidized by microwave‐assisted sulfonitic treatment at different times (5, 10, 15, and 30 min) and deposited onto a graphite screen printed electrodes. Oxidized MWCNTs were characterized and the electrochemical performance evaluated. The best sensor in terms of sensitivity and stability was obtained after 15 minutes of oxidation (SPE/CNT15). A significant reduction of the NADH oxidation potential was recorded for oxidized MWCNTs compared with unmodified MWCNTs (0.270 V and 0.500 V, respectively vs. Ag/AgCl pseudo reference electrode), increasing the selectivity of the system. Chronoamperometric calibration curves carried out applying a potential of 0.3 V for 1 min were linear in the 4–35 μM range of NADH. A limit of detection of 1 μM was achieved with negligible surface fouling (three consecutive calibration curves, 30 total measurements: slope decrease 5.9 %). Inter electrode reproducibility (n=13) was good resulting in RSD of 15.2 % and 5.0 % for the peak intensity and the oxidation potential, respectively. Quantification of glucose in white wine samples was carried out to demonstrate the ability of the NADH sensor to work in real samples. A good correlation with a spectrophotometric kit for the glucose quantification was achieved.
Ketogenic diet for treatment of intractable epilepsy in adults: A meta‐analysis of observational studies
Authors: Liu Hongyan , Yang Yi , Wang Yunbing , Tang Hong , Zhang Fan , Zhang Yong , Zhao Yong 
Published: January 2018

SummaryThe ketogenic diet (KD) is an effective treatment for children with drug‐resistant epilepsy and has been widely used in young children. Adult patients with intractable epilepsy would also benefit from this dietary treatment. However, only a few studies have been published, and the use of the KD in intractable epilepsy in adults has been limited. This meta‐analysis summarized the findings of the relevant published studies to identify the efficacy of the KD for the treatment of intractable epilepsy in adults. In this meta‐analysis, PubMed, Embase, and Cochrane Library were used for searching studies concerning the effects of the KD and its major subtypes with intractable epilepsy in adults published up to January 10, 2017. The primary outcomes were seizure freedom, seizure reduction by 50% or more, and seizure reduction by <50%. The quality of the methodology of the observational studies was reviewed by using the Newcastle‐Ottawa Scale. We identified 402 articles, of which, 16 studies including 338 patients met the inclusion criteria. The results of the meta‐analysis showed that the combined efficacy rates of all the symptoms of seizure freedom, seizure reduction by 50% or more, and seizure reduction below 50% in adults with intractable epilepsy were 13%, 53%, and 27%, respectively. The adverse reactions of the KD were mild, whereas low glycemic index diet (LGID) and low‐dose fish oil diet (LFOD) may have fewer side effects. Weight loss, high level of low‐density lipoprotein, and elevated total cholesterol were most frequent. The meta‐analysis indicates that the KD for refractory epilepsy in adults is a well‐tolerated treatment and that its side effects are acceptable, which show that the KD is a promising treatment in adult intractable epilepsy. Further research is needed to assess which type of diet or ratio is more effective in the KD treatment.
Petrogenesis and tectonic implication of the Late Mesozoic volcanic rocks in East Mongolia
Authors: Bars Amarjargal , Miao Laicheng , Fochin Zhang , Baatar Munkhtsengel , Anaad Chimedtseren , Togtokh Khasmaral 
Published: January 2018

This paper presents new geochemical and geochronological data of the Late Mesozoic volcanic rocks in East Mongolia. These volcanic rocks belong to high‐K calc‐alkaline and shoshonitic series and exhibit features of bimodal rocks. The mafic rocks have elevated incompatible trace element concentrations and significantly negative Nb, Ta, and Ti anomalies, with 87Sr/86Sr(i) and ƐNd(t) values of 0.70502–0.70572 and −1.72459 to +1.720736, respectively, which suggest that the mafic magma was derived from a lithospheric mantle source that might have been metasomatized by subduction‐derived fluids, experienced fractional crystallization, and was contaminated by crustal materials. The felsic rocks have similar rare earth element patterns to the mafic rocks but show much more significantly negative Eu and Sr anomalies. The felsic rocks have higher 87Sr/86Sr(i) values of 0.706496–0.71104 than the mafic rocks but similar ƐNd(t) values (−0.28003 to +2.928506) to the mafic ones. These data indicate that the felsic rocks originated from partial melting of a crustal source that is dominated by juvenile mafic rocks. Our new K‐Ar dating, together with previous data, shows that the Late Mesozoic volcanism in East Mongolia took place during the Late Jurassic‐Early Cretaceous between ca. 155 and 99 Ma. The model of back‐arc extension, possibly induced by slab rollback of the westward subducted Pacific Plate and the subduction zone retreat, can explain the geodynamic setting and the eastward younging trend of the Late Mesozoic volcanism in East Mongolia and in adjacent NE China.
Braided–meandering system evolution in the rock record: Implications for climate control on the Middle–Upper Jurassic in the southern Junggar Basin, north‐west China
Authors: Yao Zongquan , Yu Xinghe , Shan Xin , Li Shunli , Li Shengli , Li Yalong , Tan Chengpeng , Chen Hongliang 
Published: January 2018

This paper presents the current body of knowledge regarding the evolution of a braided–meandering system in the southern Junggar Basin, north‐west China, based on the preserved architecture evidences. The response to climate change was also discussed. Herein, 10 types of lithofacies are summarized, including information of their primary sedimentary structures, characteristic lithology, and geometry. This study focuses on recognizing the architectural elements within the channels (migrating channel: CHm, switching channel: CHs, transiting channel: CHt, and filling channel: CHf), the bar units (downstream accretion: DA, lateral accretion: LA, unit bar: UB, and compound bar: CB), and fine‐grained clastic deposits (floodplain fines: FF and overbank fines: OF). Three representative sections of outcrops were selected, and detailed observation and analysis of these sections revealed 3 stages can be divided: the braided stage, in which the deposits show an evidence of CHm, DA elements which are the mainly architectural elements, multichannel with aggradational filling; The transformation between braided–meandering stage, during which the fluvial system consists of CHt and CHm elements with lateral accretion; and meandering stage which is characterized by dominance of CHm, LA elements, and the channels become isolated and meandering. Finally, this paper concludes with an interpretation of climate events as manifested by the fluvial archives of the colours of sedimentary rocks, special mineral, palaeontology, geochemistry spanning the Middle–Upper Jurassic (between 166.1 and 152.1 Ma).
Assessing the availability, price, nutritional value and consumer views about foods and beverages from vending machines across university campuses in regional New South Wales, Australia
Authors: Ng Ker Wei , Sangster Janice , Priestly Jacqueline 
Published: January 2018

AbstractIssue addressedVending machines are ubiquitous. However, there is limited evidence on the nutritional value of food and beverages vended on university campuses and on the views of potential users. This study identified the availability, price and nutritional value of food and beverages vended on regional university campuses and investigated the views of university staff and students.MethodsThe availability and price of food and beverages vended on five regional university campuses were assessed by direct observation. Volunteers (n = 222) completed an anonymous, online or paper survey to assess their perspectives on products available in campus vending machines.ResultsSixty per cent of 1259 slots identified in 49 vending machines were for foods and 40% were for beverages. Almost all foods (93%) and the majority of beverages (53%) vended were categorised as “less healthy.” The mean difference between the prices of healthier and less healthy foods and beverages was $0.72 and $0.16, respectively, but these differences were not statistically significant. Nearly 40% of participants were unsatisfied with the products available.ConclusionVending machines on regional university campuses contained a high proportion of energy‐dense nutrient‐poor foods which contribute to an obesogenic environment. Regional university staff and students desire healthier vending options.So what?Findings can be used to inform stakeholders of the need to improve the nutritional quality of food and beverages vended on regional university campuses. Development of food policy for university settings and adoption of strategies to improve the availability and price of healthy foods would promote healthier food choices.
A multilevel factor model: Identification, asymptotic theory and applications
Authors: Choi In , Kim Dukpa , Kim Yun Jung , Kwark Noh‐Sun 
Published: January 2018

SummaryThis paper studies a multilevel factor model with global and country factors. The global factors affect all individuals, whereas the country factors affect only those within each specific country. A sequential procedure to identify the global and country factors separately is proposed. In the initial step, the global factors are estimated by canonical correlation analysis. Using this initial estimator, the principal component estimators (PCEs) of the global and country factors are constructed. It is shown that the PCEs estimate the spaces of the global and country factors consistently and are normally distributed in the limit. Several information criteria that can estimate the number of country factors are proposed. The number of global factors is assumed to be known. Extensive simulation results demonstrate that the sequential procedure and information criteria work well in finite samples. The method of this paper is applied to 25 OECD countries to identify an international business cycle. It is reported that the method extracts a global factor reasonably well.
Self‐production of oxygen system CaO2/MnO2@PDA‐MB for the photodynamic therapy research and switch‐control tumor cell imaging
Authors: Ji Chenhui , Lu Zhongzhong , Xu Yonghui , Shen Beibei , Yu Shiyong , Shi Dan 
Published: January 2018

AbstractPhotodynamic therapy (PDT) holds promise in biochemical study and tumor treatment. A novel multifunctional nanosystem CaO2/MnO2@polydopamine (PDA)‐methylene blue (MB) nanosheet (CMP‐MB) was designed. CaO2 nanoparticles were encapsulated by MnO2 nanosheet, and then PDA was coated on the surface of CaO2/MnO2 nanosheets, which could adsorb photosensitizer MB through hydrophobic interaction or π‐π stacking. In this nanosystem, CaO2/MnO2 had the ability of self‐production of oxygen, which solved the problem of tumor hypoxia largely. Moreover, it is worth mentioning that the fluorescence of MB was suppressed by MnO2, while its emission was triggered in the simulated tumor microenvironment. Therefore, CMP‐MB nanosheet could be used to switch‐control cell imaging potentially. 3‐(4,5‐dimethyl‐thiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide testing and Live/Dead assay confirmed CMP‐MB nanosheet had fewer side effects without illumination while it destroyed Hela cell with the illumination of light. Vitro cell experiment demonstrated CMP‐MB nanosheet could achieve tumor microenvironment responsive imaging and inhibit tumor cell growth under illumination effectively. Therefore, the system has great potential for PDT application and switch‐control tumor cell imaging. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2544–2552, 2018.
An Efficient Green Synthesis of Some Functionalized Spiro Chromene Based Scaffolds as Potential Antitubercular Agents
Authors: Khan Gulzar A. , Naikoo Gowhar A. , War Javeed A. , Sheikh Imtiyaz A. , Pandit Umar Jan , Khan Imran , Harit Amit K. , Das Ratnesh 
Published: January 2018

A facile multicomponent one pot synthesis of novel spiro [chromene‐2, 2‐pyrollidin]‐4′‐one derivatives3a–lwas conveniently carried out in acetic acid at feasible reaction conditions. The reaction mechanism operates through two key intermediates 3‐N‐aryliminocoumarin and coumarinylidene acetone. This protocol is an environmentally benign preparation and gives excellent yields of the target compounds (77–92%). The structure of new compounds were determined by spectroscopic techniques like FTIR,1H NMR,13C NMR, and MS. Docking studies against enoyl‐acyl carrier protein reductase predicts that the compounds bind at the active site with higher binding affinity values. The compound3k(MIC, 10 μg/mL) shows comparable activity in reference with Isoniazid at the same concentrations against MT H37 Rv.
The investigation of substituent effects on the fragmentation pathways of pentacoordinated phenoxyspirophosphoranes by ESI‐MSn
Authors: Cui Xiaoyan , Sun Can , Zhao Pei , Wang Yanyan , Guo Yanchun , Zhao Yufen , Cao Shuxia 
Published: January 2018

AbstractThe fragmentation pathways of pentacoordinated phenoxyspirophosphoranes were investigated in the positive mode by electrospray ionization multistage mass spectrometry. The results demonstrate that the sodium adducts of the title compounds undergo two competitive fragmentation pathways, and the fragmentation patterns are heavily dependent on the various substituent patterns at the phenolic group. An electron‐withdrawing substituent at the ortho‐position always results in the removal of a corresponding phenol analogue, while cleavage by spiroring opening becomes the predominant fragmentation pathway if an electron‐donating substituent is at the phenolic group. The substituent effects on the competitive fragmentation pathways were further elucidated by theoretical calculations, single crystal structure analysis, and high‐resolution mass spectrometry. The results contribute to the understanding of the gas‐phase fragmentation reactions and the structure identification of spirophosphorane analogues by electrospray ionization multistage mass spectrometry.
The dynamic relationship between multiple team membership and individual job performance in knowledge‐intensive work
Authors: van de Brake Hendrik J. , Walter Frank , Rink Floor A. , Essens Peter J. M. D. , van der Vegt Gerben S. 
Published: January 2018

SummaryMany employees in modern, knowledge‐based organizations are concurrently involved in more than one team at the same time. This study investigated whether a within‐person change in such individual multiple team membership (MTM) may precede and may be predicted by changes in an employee's overall job performance. We examined this reciprocal relationship using longitudinal archival data from a large knowledge‐intensive organization, comprising 1,875 employees and spanning 5 consecutive years. A latent change score model demonstrated that an increase in an employee's MTM was associated with a subsequent decrease in his or her overall job performance evaluations. By contrast, an increase in job performance was associated with a subsequent increase in an employee's MTM. Moreover, our results indicated that although an increase in an individual employee's MTM initially decreases his or her job performance, in the long run, this increase in MTM was associated with higher job performance. Together, these results suggest a dynamic association between an individual employee's MTM and his or her overall job performance, such that these variables are mutually connected in a highly complex manner over time.