bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum uric acid and prostate cancer: findings from the NHANES (2007–2020)
Authors: Yan Yu , Lin Hong , He Zhiyao , Wang Ling 
Published: October 2024

BackgroundThe relationship between serum uric acid (SUA) levels and prostate cancer (PCa) remains controversial. This cross-sectional study investigated the association between SUA levels and PCa incidence.MethodsA total of 9,776 participants aged ≥40 from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2020 were included, 503 of whom had PCa. Weighted univariate logistic regression, multivariate logistic regression, and smooth-fitting curve analyses were used to analyze the association between SUA and PCa incidence. Concurrently, the fitted smoothing curves were used to explore the potential non-linear relationships. If non-linearity was observed, a recursive algorithm further calculated the inflection point.ResultsThree models were used to analyze the correlation between SUA levels and PCa incidence. All regression models demonstrated a negative correlation between SUA levels and PCa incidence (model 1: OR = 0.88, 95% CI=0.80–0.97; model 2: OR = 0.87, 95% CI=0.80–0.96; model 3: OR = 0.87, 95% CI=0.78–0.96). According to the trend test, with increasing SUA, the risk of PCa showed a downward trend (three models P for trend = 0.037, 0.015, 0.016). According to the subgroup analysis, a significant negative correlation between SUA and PCa was detected in individuals aged &gt;60 years, non-Hispanic whites, those of other races, and those with hypertension. Moreover, the association between SUA and PCa followed a U-shaped curve among participants without hypertension, and the inflection point of SUA was 5.1 mg/dl.ConclusionsThis cross-sectional study revealed a negative relationship between SUA levels and the risk of PCa, particularly in specific demographic groups. These findings offer a fresh perspective on the role of SUA in PCa patients, potentially paving the way for new approaches for the prevention and treatment of PCa. However, further studies are necessary to validate these findings.
Intraoperative radiotherapy might not serve as a standard therapy for retroperitoneal liposarcoma: insights from a population-based propensity score-matched study
Authors: Zhou Xiao , Zhuang Aobo , Li Xi , Xi Zhe , Cheng Yingxue , Yan Guangting , Wang Yue , Zhang Gen , Huang Yangyang , Zhang Chenhe , Xie Fuan , Ma Xin , Wu Ting , Li Wengang 
Published: October 2024

BackgroundDifficulty in achieving complete resection leads to a poor prognosis for retroperitoneal soft tissue sarcoma, hence emphasizing the significance of adjuvant treatment. The benefit of preoperative radiotherapy for retroperitoneal liposarcoma was initially demonstrated by the STRASS trial. However, the impact of intraoperative radiotherapy (IORT) on retroperitoneal liposarcoma remains unexplored.MethodPatients with retroperitoneal liposarcoma were identified in the Surveillance, Epidemiology, and End Results (SEER) database, treated between 2000 and 2019. Subsequently, a 1:1 propensity score-matched (PSM) analysis was conducted based on variables identified from a multivariate analysis. T-tests were used to assess differences in normally distributed continuous variables, while the rank-sum test was applied to variables that did not follow a normal distribution. The chi-squared test was utilized to evaluate differences in categorical variables. Ultimately, survival analysis was performed using SPSS to evaluate patient prognosis.ResultA total of 2129 patients with retroperitoneal liposarcoma were included in our study. Age, sex, histology, grading, chemotherapy, and tumor size as independent prognostic risk factors for these patients through multivariate Cox regression analysis. Subsequently, 66 patients were included in the survival analysis through PSM, with 33 patients receiving IORT. Finally, the survival analysis revealed that there was no difference in overall survival among patients with retroperitoneal liposarcoma, regardless of whether they received IORT or not (p= 0.711).ConclusionAs an exploratory study, our findings suggest that patients may not derive benefit from intraoperative radiotherapy. These observations are intended to lay the groundwork for future prospective clinical studies.
Clinical-radiomics nomogram based on the fat-suppressed T2 sequence for differentiating luminal and non-luminal breast cancer
Authors: Guo Yaxin , Li Shunian , Liao Jun , Guo Yuqi , Shang Yiyan , Wang Yunxia , Wu Qingxia , Wu Yaping , Wang Meiyun , Tan Hongna 
Published: October 2024

ObjectiveTo establish and validate a new clinical-radiomics nomogram based on the fat-suppressed T2 sequence for differentiating luminal and non-luminal breast cancer.MethodsA total of 593 breast cancer patients who underwent preoperative breast MRI from Jan 2017 to Dec 2020 were enrolled, which were randomly divided into the training (n=474) and test sets (n=119) at the ratio of 8:2. Intratumoral region (ITR) of interest were manually delineated, and peritumoral regions of 3 mm and 5 mm (PTR-3 mm and PTR-5 mm) were automatically obtained by dilating the ITR. Intratumoral and peritumoral radiomics features were extracted from the fat-suppressed T2-weighted images, including first-order statistical features, shape features, texture features, and filtered features. The Mann-Whitney U Test, Z score normalization, K-best method, and least absolute shrinkage and selection operator (LASSO) algorithm were applied to select key features to construct radscores based on ITR, PTR-3 mm, PTR-5 mm, ITR+PTR-3 mm and ITR+ PTR-5 mm. Risk factors were selected by univariate and multivariate logistic regressions and were used to construct a clinical model and a clinical-radiomics model that presented as a nomogram. The performance of models was assessed by sensitivity, specificity, accuracy, the area under the curve (AUC) of receiver operating characteristic (ROC), calibration curves, and decision curve analysis (DCA).ResultsITR+PTR-3 mm radsore and histological grade were selected as risk factors. A clinical-radiomics model was constructed by adding ITR+PTR-3mm radscore to the clinical factor, which was presented as a nomogram. The clinical-radiomics nomogram showed the highest AUC (0.873), sensitivity (72.3%), specificity (78.9%) and accuracy (77.0%) in the training set and the highest AUC (0.851), sensitivity (71.4%), specificity (79.8%) and accuracy (77.3%) in the test set. DCA showed that the clinical-radiomics nomogram had the greatest net clinical benefit compared to the other models.ConclusionThe clinical-radiomics nomogram showed promising clinical application value in differentiating luminal and non-luminal breast cancer.
Nodal radiotherapy for prostate adenocarcinoma recurrence: predictive factors for efficacy
Authors: Gueiderikh Anna , Baude Jérémy , Baron David , Schiappa Renaud , Katsahian Sandrine , Moreau Damien , Laurans Marc , Bibault Jean-Emmanuel , Kreps Sarah , Bondiau Pierre-Yves , Quivrin Magali , Lépinoy Alexis , Pasquier David , Hannoun-Levi Jean-Michel , Giraud Philippe 
Published: October 2024

BackgroundNodes are the second site for prostate cancer recurrence. Whole-pelvic radiotherapy (WPRT) has shown superiority over nodal stereotactic body radiotherapy (SBRT) in two retrospective cohorts. We aimed to compare both modalities and assess factors associated with treatment outcomes.Materials and methodsThis retrospective multicentric cohort study included patients from five institutions spanning from 2010 to 2022. Patients had a history of prostatic adenocarcinoma classified as N0 M0 at diagnosis with a first nodal-only pelvic castration-sensitive recurrence. Failure-free survival (FFS) was defined as the time from the end of RT to the first failure event–biochemical or imaging recurrence, or death.ResultsA total of 147 patients (pts) were analyzed, mainly treated for a recurrence after initial prostatectomy (87%), with 64 (43.5%) undergoing SBRT and 83 (56.5%) undergoing WPRT. SBRT was chosen mainly for dosimetric constraints (67%) and was associated with a lower rate of concomitant androgen deprivation therapy (ADT) prescription. With a median follow-up of 68 months [inter-quartile range (IQR) = 51], FFS was significantly lower in the SBRT group (p &lt; 0.0001). In multivariable analysis, WPRT and ADT were associated with a longer FFS. Factors associated with a longer FFS after SBRT included associated ADT, lower prostate-specific antigen (PSA) levels, a PSA doubling time &gt;6 months, and a Gleason score &lt;8. SBRT was associated with a lower rate of genitourinary and gastrointestinal grade ≥2 complications.DiscussionFor an isolated pelvic nodal prostate cancer recurrence, SBRT is associated with a shorter FFS compared to WPRT. SBRT is often more convenient for patients and leaves further pelvic salvage options available, so it can be explored as an option for well-informed patients.
Clinical risk factors of bevacizumab-related hypertension in patients with metastatic colorectal cancer: a retrospective study
Authors: Zheng Zhuoling , Zhao Yihong , Xie Jingwen , Gao Min , Wang Yiting , Li Xiaoyan 
Published: October 2024

IntroductionBevacizumab, a vascular endothelial growth factor (VEGF) inhibitor, is widely used as a first-line treatment for metastatic colorectal cancer (mCRC), with hypertension being a common adverse effect. However, there is limited data on the predisposing factors contributing to bevacizumab-induced blood pressure (BP) elevation. This study aims to identify clinical risk factors associated with bevacizumab-related hypertension in patients with mCRC.MethodsThis retrospective study included 178 patients treated between January and June 2020. Demographic data and medical histories were extracted from hospital electronic medical records.ResultsAmong the 178 patients, 54 (30.3%) developed bevacizumab-related hypertension, with a median onset time of 48 days. Univariate and multivariate analyses identified pre-existing hypertension [odds ratio (OR), 3.30; 95% confidence interval (CI), 1.56–6.99] and age ≥60 years (OR, 2.04; 95% CI, 1.00–4.17) as independent risk factors for bevacizumab-related hypertension. The area under the receiver operating characteristic (ROC) curve was 0.66 (95% CI, 0.57–0.75, P &lt; 0.001). The median overall survival (OS) for the cohort was 30.53 months (95% CI, 22.23–38.84). No significant differences in OS were observed between patients with and without bevacizumab-related hypertension (31.13 vs. 27.87 months, P = 0.86).ConclusionPre-existing hypertension and age ≥60 years are significant clinical risk factors for bevacizumab-related hypertension in mCRC patients. Bevacizumab-related hypertension did not affect overall survival. Clinicians should closely monitor BP within the first 2 months of bevacizumab treatment in high-risk patients.
The mindful resiliency in recovery model: empowering the transcendence of stigma
Authors: Moniz-Lewis David I. K. 
Published: October 2024

IntroductionMindfulness-based interventions show unique promise in treating substance use disorders among marginalized populations who face heightened stigma. The Mindful Resiliency in Recovery Model is introduced as a novel theoretical framework articulating how mindfulness training can mitigate the adverse effects of stigma, enhance psychological resilience, and facilitate sustained recovery from addiction.MethodsThe current manuscript synthesizes various models of mindfulness processes, stigma, and substance use disorder recovery to propose an integrated theoretical framework on the promise of mindfulness-based interventions in supporting recovery. Further, the current manuscript draws upon empirical literature to establish preliminary support for the premises and hypotheses of the Mindful Resiliency in Recovery Model concerning the mechanisms influencing the efficacy of mindfulness-based interventions among marginalized individuals.ResultsPreliminary evidence supports the premises of the proposed model. There is evidence to suggest that specific processes like increased present-moment awareness, acceptance, decentering, reappraisal, and savoring may be especially salient in mitigating internalized stigma and fostering resiliency in recovery. There is a need for additional research on these processes, and contextual factors that may moderate their efficacy.DiscussionThe Mindful Resiliency in Recovery Model has significant implications for optimizing mindfulness-based interventions to empower marginalized individuals to transcend stigma and actualize their capacity for wellbeing in substance use disorder recovery. It provides a roadmap for future research on the mechanisms and contextual factors affecting the efficacy of mindfulness-based interventions for marginalized and stigmatized communities. It further offers guidance to clinicians utilizing mindfulness-based interventions to support individuals experiencing stigma.
Flourishing levels among health and non-health profession students in Saudi Arabian colleges
Authors: Shdaifat Emad , Alshowkan Amira , Alqahtani Friyal , Alebiary Hoda , AL-Qahtani Mona , Alsaleh Nagla , Kamel Neama 
Published: October 2024

ObjectivesThis study aimed to evaluate the levels of flourishing among university students, compare these levels between students in health-related and non-health-related colleges, and identify factors that predict flourishing.MethodsA cross-sectional study was conducted at Imam Abdulrahman Bin Faisal University, Saudi Arabia, involving 1,148 students from the first to fourth year across both academic sectors. Data were collected utilizing the self-reported Global Flourishing Study Questionnaire (GFS) during the period from September 2023 to June 2024. Multistage sampling techniques were employed to ensure a representative sample, with data collection facilitated through a self-administered electronic link on QuestionPro resulting in a response rate of 51.7%. Data analysis was performed using SPSS version 22, incorporating descriptive statistics, t-tests, ANOVA, and regression analysis to identify predictors of flourishing. The reliability and validity of the questionnaire were assessed using Cronbach’s alpha and Pearson’s correlation analysis.ResultsThe study included nearly equal proportions of students from health (51.0%) and nonhealth (49.0%) colleges. The average flourishing score was 85.6 (SD=18.6), with a slight increase in health colleges (85.7) compared with non-health colleges (85.4). Factors that significantly affected flourishing included gender, employment status, exercise frequency, experiences of abuse, and income. In the multiple regression analysis, well-being emerged as the strongest predictor, followed by external factors, disposition, and behavior. Gender exhibited a positive association with flourishing, whereas religion had a negative influence. Furthermore, employment and higher income levels were found to positively contribute to flourishing.ConclusionThis study revealed elevated levels of flourishing among university students in Saudi Arabia, with a notable average score of 85.6. Although the differences between students enrolled in health-related and non-health-related colleges were minimal, significant predictors of flourishing were identified, including well-being, external factors, disposition and behavior, gender, religious affiliation, employment status, income, frequency of exercise, and experience of abuse. These findings underscore the complexity of flourishing and highlight the necessity of considering a range of sociodemographic and lifestyle factors to promote student well-being.
Association of diuretics with falls and wrist fractures: a Mendelian randomization study
Authors: Liu Fei , Dai Jun-ze , Deng Xiao-xi , Cao Ren-shuang , Cheng Yong-zhong , Wang Chao-lu 
Published: October 2024

BackgroundThe association between diuretics and falls in older adult has been reported in previous studies, but discrepancy remains between the different types of diuretics. The association of diuretics with the risk of wrist fractures due to diuretics is also unclear. Therefore, in this study, we determined the association of diuretics with falls and wrist fractures by Mendelian randomization.MethodsWe used a two-sample Mendelian randomization (MR) approach to evaluate the effects of the loop diuretics\potassium-sparing diuretics\thiazide diuretics (LDs\PSDs\TDs) on the risk of falls and wrist fracture using the three diuretic-associated genetically-predicted single nucleotide polymorphisms (SNPs) as genetic tools. The inverse variance weighting (IVW) method was used as the main evaluation method, with odds ratio (OR) as the evaluation criterion. Additionally, weighted median (WME), MR-Egger, weighted mode (WM) and simple mode (SM) methods were used together for the MR analysis, and sensitivity analyses were performed to assess the robustness of the main results.ResultA total of 35 SNPs were included in this study as instrumental variables to replace LDs, PSDs, and TDs, which were 24, 7, and 4. Genetic substitutions for diuretics associated with increased risk of falls were LDs (OR = 1.012043, 95%CI: 1.001607–1.022588, p = 0.022337), PSDs (OR = 1.023794, 95%CI: 1.005605–1.042312, p = 0.010138). Genetically proxied TDs showed no association with falls, but the use of TDs showed a negative correlation with the incidence of wrist fracture (OR = 0.833, 95%CI: 0.767–0.905, p &lt; 0.001). The Cochran Q-test showed no heterogeneity and MR-PRESSO method excluded data pleiotropy.ConclusionOur findings suggest that the use of loop diuretics (LDs) or potassium-sparing diuretics (PSDs) increases the incidence of falls, but there is no causal relationship between thiazide diuretics (TDs) and falls, and TDs may actually reduce the risk of wrist fractures. Clinical use of diuretics necessitates vigilance and appropriate preventive measures to minimize fall-related events.
Physical activity as a predictor of activities of daily living in older adults: a longitudinal study in China
Authors: Wang Ling-Ying , Chen Hong-Xiu , Zhu Hong , Hu Zi-Yi , Zhou Chun-Fen , Hu Xiu-Ying 
Published: October 2024

ObjectiveThis study aimed to assess the prevalence of physical activity and its association with the progression of difficulty performing activities of daily living among older adults in China.MethodsA population-based prospective cohort study based on China Family Panel Studies (CFPS) data was conducted in 2018 and 2020. This study used a logistic model to empirically estimate the effects on daily living activities among older adults.ResultsA total of 2073 older adults aged 60 years and above were included, 78.0% of whom did not exercise. The logistic regression model revealed several predictive factors for activity of daily living decline among older adults. These included residence status (OR = 0.672; 95% CI 0.519–0.869; p = 0.002), age (OR = 0.307; 95% CI 0.169–0.557; p &lt; 0.001), ethnicity (OR = 0.511; 95% CI 0.338–0.773; p = 0.001), education level (OR = 2.180; 95% CI 1.366–3.479; p &lt; 0.001), job (OR = 0.601; 95% CI 0.447–0.810; p = 0.001), chronic disease (OR = 0.769; 95% CI 0.604–0.978; p = 0.032) and physical activity (less: OR = 0.464; 95% CI 0.300–0.720; p = 0.001; adequate: OR = 0.512; 95% CI 0.321–0.816; p = 0.005).ConclusionOur findings indicate that insufficient physical activity is particularly acute among the older adults. Physical activity has emerged as a significant predictor of decreased daily living activities among older adults. Our research underscores that less and adequate physical activity can prevent a reduction in daily living activities, in contrast to a lack of exercise. The most effective threshold for daily exercise frequency is a session per day, while the ideal exercise duration is 15 min. Additionally, the desired intensity for exercise is characterized by rapid breathing and a noticeable heartbeat, accompanied by slight perspiration. Community nurses play a pivotal role in providing health education on daily exercise to the older adults. It is crucial for nurses in community hospitals to closely monitor the daily exercise habits of the older adults, actively disseminate the benefits of exercise, and enhance their current exercise regimens through effective health education, ultimately improving their quality of life.
Effects of a 30-min rest with a nap chair on task performance, sleepiness, and neurophysiological measures in men with suspected brain fatigue: a randomized controlled crossover trial
Authors: Fujino Minoru , Inoue Mikio , Sonoda Yoshiharu , Kono Suminori , Wakana Chikako , Mawatari Shiro , Fujino Takehiko 
Published: October 2024

BackgroundIt has been suggested that a short nap in the afternoon may improve sleepiness, alertness, and task performance. The present study evaluated the effects of a 30-min rest with a new nap chair on task performance, sleepiness, and neurophysiological measures.MethodsA randomized controlled crossover trial with a 1-week interval was carried out at the BOOCS Clinic Fukuoka in Japan. The subjects were male workers aged 20 to 64 years with suspected brain fatigue, which was defined by the Profile of Mood Status 2. The intervention was a 30-min rest with an office chair or a nap chair. The primary outcome was the performance in the Uchida-Kraepelin test. The secondary outcomes included the Karolinska Sleepiness Scale and 15-min heart rate variability (HRV). The changes after the nap-chair rest and office-chair rest were compared. Repeated measures analysis of variance with nesting was used in the statistical analysis.ResultsTwenty participants were eligible and entered the crossover trial. The overall 15-min score in the Uchida-Kraepelin test improved after the nap-chair rest and after the office-chair rest to almost the same extent (5.9 vs. 5.5 points, P = 0.68). The Karolinska Sleepiness score significantly decreased after the nap-chair rest, and the between-treatment difference in the decrease was highly significant (P = 0.0004). The average duration of sleep during rest was prominently longer in the nap-chair rest than in the office-chair rest (19.0 vs. 7.6 min, P = 0.002). No participants experienced REM sleep during the rest. LF and HF powers of the HRV were greater during the nap-chair rest than during the office-chair rest, the difference in the HF power being substantial.ConclusionA 30-min rest with the nap chair did not appreciably improve the performance in the Uchida-Kraepelin test as compared with the office-chair rest. The nap-chair rest induced a substantially longer sleep accompanied with a parasympathetic activation, thereby resulting in a material improvement in sleepiness after the rest.
A Study on Effectiveness of Yoga for Improvement of Work Productivity among Millennials in Tiruchirappalli
Authors: Vaishnavi B , Booma Devi S 
Published: October 2024

Yoga has been great art and science of healthy living. Positive health is an important means of leading meaningful life filled with happiness and inner harmony. With rapid economic development and increasing westernization of lifestyle in past few decades there is a change in the behavioural pattern of human being. This article focuses on the effectiveness of yoga for improvement of work productivity among millennials. The regular practice of yoga is a solution for the many psychological and lifestyle disorders of the modern life with the revitalization of the traditional inheritance along the lines of the sustainable approach. It was observed that, all the responders said that yoga is beneficial in their life as it helps them to attain inner peace, productive mind, strong immunity and balanced work life as well. Thus, it can be concluded that, practicing yoga makes life healthy and increased their productivity.