bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone‐Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy
Authors: Chen Lin , Wang Xin , Lin Zi‐Xuan , Dai Jian‐Guo , Huang Yu‐Fang , Zhao Yu‐Nan 
Published: June 2017

To further explore the underlying antidepressant mechanism of ginseng total saponins (GTS), this study observed the effects on hippocampal astrocyte structural plasticity and hippocampal volume in the corticosterone‐induced mouse depression model. Corticosterone (20 mg/kg/day) was administered subcutaneously for 5 weeks, and GTS (12.5, 25, and 50 mg/kg/day; namely GTSL, GTSM, and GTSH) or fluoxetine (10 mg/kg/day) were given intragastrically during the last 3 weeks. On day 33 and day 34, depression‐like behavior was observed via a forced swimming test and a tail suspension test, respectively. At 6 h after the last dose of corticosterone (day 35), all mice were sacrificed followed by serum corticosterone assays, stereological analysis of hippocampal glial fibrillary acidic protein‐positive (GFAP+) astroctyes and hippocampal volume, and hippocampal glycogen tests. Results showed that all doses of GTS ameliorated depression‐like behavior and the decrease in hippocampal glycogen without normalizing hypercortisolism. Moreover, GTSH and GTSM reversed the corticosterone‐induced reduction in the total number of hippocampal GFAP+ astrocytes and hippocampal volume. Additionally, GTSH alleviated the diminished protrusion length and somal volume of GFAP+ astrocytes induced by corticosterone. These findings imply that the effects of GTS on corticosterone‐induced depression‐like behavior may be mediated partly through the protection to hippocampal astrocyte structural plasticity. Copyright © 2017 John Wiley & Sons, Ltd.
Microwave Synthesis of Coumarinyl Substituted Pyridine Derivatives as Potent Anticancer Agents and Molecular Docking Studies
Authors: Chougala Bahubali M. , S Samundeeswari , Holiyachi Megharaja , Naik Nirmala S. , Shastri Lokesh A. , Dodamani Suneel , Jalalpure Sunil , Dixit Sheshagiri R , Joshi Shrinivas D. , Sunagar Vinay A 
Published: June 2017

AbstractCatalyst free new bioactive 2‐amino‐4‐(2‐oxo‐2H‐chromen‐4‐yl)‐6‐arylpyridine‐3‐carbonitrile molecular entities (2 a‐2 o) have been synthesized from 4‐formylcoumarins with malononitrile, different ketones and ammonium acetate via one‐pot four component coupling reaction under neat microwave method. Detailed characterization of all the compounds and anticancer properties for the synthesized compounds are reported. Compounds 2 f and 2 k exhibited promising anticancer activity at low concentration (10−5 M) against NCI‐60 cell lines. Further, IC50 values were calculated for most potent compounds against three cancer cell lines such as HT‐29, Hep‐G2 and KB. Among the eight compounds, 2 f and 2 k are exhibited most promising activity, the potent anticancer molecules 2 f and 2 k were screened for their CT‐DNA cleavage and fluorescence quenching study with transport protein BSA. Molecular docking study has been performed for the synthesized compounds with binding site of the tubulin using podophyllotoxin‐tubulin stathmin‐like domain complex (PDB 1SA1) and results obtained are quite good.
Citrate Stabilized Hierarchical SPIO Nanostructures: Synthesis and Application Towards Effective Removal of Toxin, Microcystin‐LR from Water
Authors: Narasimha Gundeboina , Mahesh Adimoolam Ganga , Manorama Sunkara V. 
Published: June 2017

AbstractHierarchical hollow nanostructures because of their unique structural, physical and chemical properties make them potentially attractive in various fields like catalysis, delivery vehicles, sensors, photonic devices, optics and as adsorbents. The present study deals with a simple method for the synthesis of citrate stabilized hierarchical hollow superparamagnetic Fe3O4 nanospheres (SPION's) for the facile removal of Microcystin‐LR (MC–LR), a cyanobacteria produced toxin from water. The morphological and structural evaluation confirms the formation of magnetite Fe3O4 hollow nanospheres of size around 300 nm by the assembly of 10 nm sized nanoparticles. The magnetic studies showed that the as prepared spheres were superparamagnetic at room temperature, with saturation magnetization around 50–60 emu/g and negligible remanence and coercivity. The amount of MC–LR adsorbed on the SPION's was estimated by HPLC and higher adsorption was observed in hollow Fe3O4 spheres. The superparamagnetic nature of hollow Fe3O4 makes the extraction of MC–LR from water convenient improving the efficiency of water treatment, making it reusable and cost effective.
Pyridopyrimidinone Derivatives as DNAG‐Quadruplex‐Stabilizing Agents: Design, Synthesis and Biophysical Studies
Authors: Malhotra Rajesh , Rarhi Chhanda , Diveshkumar K. V. , Bommisetti P. , Pany Sushree Prangya P. , Roy Subho , Pradeepkumar P. I. , Kundu Mrinalkanti 
Published: June 2017

AbstractDNA can fold into non‐canonical structures such as G‐quadruplexes (G4 s) in addition to adopting the double helical structure. Considering the relationship between stabilization of G4 structure and anticancer effects, development of G4 interactive compounds has been of significant interest. Past years have witnessed the discovery of scaffolds targeting G4 structures based on planar, multi‐aromatic ring compounds. With an aim to engineer drug‐like properties, we designed and synthesized pyridopyrimidinone based selective G4 DNA stabilizing agents 1–3, and further they were evaluated for G4 DNA recognition properties. CD melting studies revealed the preferential stabilization of parallel topology of promoter c‐MYC and c‐KIT G4 DNAs by the ligands, especially 2 and 3, over the different topologies of telomeric G4 DNA. UV melting experiments suggested that no significant stabilization was observed for duplex DNA. Further, the results from ITC experiments substantiated the preferential stabilization of parallel topology of c‐MYC G4 DNA over telomeric and duplex DNA by the ligands 2. These data showed that ligand 2 has moderate binding affinity to the c‐MYC G4 DNA and is ∼49‐fold and ∼25‐fold selective over the telomeric G4 DNA and the duplex DNA respectively. The molecular modeling and dynamics studies of the ligand 2 in complex with c‐MYC and c‐KIT1 G4 DNAs showed that this ligand stacks on the 5′‐quartet of c‐MYC and 3′‐quartet of c‐KIT1 G4 DNA structures.
Inhibition of Polyunsaturated Fatty Acids Synthesis Decreases Growth Rate and Membrane Fluidity of Rhodosporidium kratochvilovae at Low Temperature
Authors: Wang Jun , Chen Wei , Nian Hongjuan , Ji Xiuling , Lin Lianbing , Wei Yunlin , Zhang Qi 
Published: June 2017

AbstractThe intention of this study was to investigate the role of polyunsaturated fatty acids (PUFA) in the cold adaptation of Rhodosporidium kratochvilovae YM25235 by knockout of the Δ12/Δ15‐fatty acid desaturase gene (RKD12) to inactivate Δ12/Δ15‐fatty acid desaturase. Polymerase chain reaction (PCR) amplification was used to detect the genomic structure of RKD12 gene in YM25235. The RKD12 gene was knocked out by DNA homologous recombination to inhibit the biosynthesis of PUFA. Then, the contents of linoleic acid (LNA) and α‐linolenic acid (ALA) after gene knockout were investigated using a gas chromatography‐mass spectrometer, followed by determination of the growth rate and membrane fluidity of YM25235 at low temperature. After PCR amplification, a 1611 bp genomic fragment was amplified from YM25235. When the RKD12 gene was knocked out, the contents of LNA and ALA in YM25235 significantly decreased. The growth rate and membrane fluidity of YM25235 decreased significantly at low temperature. Inhibition of PUFA biosynthesis by RKD12 gene knockout influenced cold adaptation of YM25235 by decreasing the PUFA content in cell membranes and reducing the growth rate and membrane fluidity of YM25235 at low temperature.
Structure, use, and syntactic ecology in language obsolescence
Authors: Adger David 
Published: June 2017

AbstractNancy Dorian's foundational work on the loss of Gaelic in the East Sutherland communities continues to provide important insights into the nature of the process of language change in situations of obsolescence. In this article I look at a subset of Dorian's data from the perspective of current syntactic theory, and argue that the connected loss of such apparently different constructions as objects of non-finite verbs, inalienable possessive structures, and a range of passives, and the concomitant restructuring of the grammar, all follow from the interaction between a reduction in agreement features on a functional head and the broad syntactic ecology of the language. This approach makes sense of why these apparently disparate constructions all undergo the particular kinds of change that are seen, changes which are mysterious from the perspective that an obsolescing language should alter to become more like the dominant language (in this case English) which is replacing it.
HOPE FOR INTELLECTUAL HUMILITY
Authors: Cobb Aaron D. 
Published: June 2017

ABSTRACTRobert Roberts and W. Jay Wood (2007) define intellectual humility as a dispositional absence of concern for self-importance. And they contrast this virtue with distinct species of vicious pride. The aim of this project is to extend their regulative epistemology by considering how epistemic agents can cultivate a dispositional detachment from the concerns characteristic of the prideful vices of hyper-autonomy and presumption. I contend that virtuous communities help to foster intellectual humility through their role in cultivating the virtue of hope. Thus, regulative epistemology ought to focus greater attention on the role of communities in the development of intellectual virtue.
Radiocarbon Chronology of Complexes With Seima-Turbino Type Objects (Bronze Age) in Southwestern Siberia
Authors: Marchenko Z V , Svyatko S V , Molodin V I , Grishin A E , Rykun M P 
Published: June 2017

AbstractThis paper discusses the chronology of burial grounds containing specific Seima-Turbino type bronze weaponry (spears, knives, and celts). The “transcultural” Seima-Turbino phenomenon relates to a wide distribution of specific objects found within the sites of different Bronze Age cultures in Eurasia, not immediately related to each other. The majority of the Seima-Turbino objects represent occasional findings, and they are rarely recovered from burial grounds. Here, we present a new set of14C dates from cemeteries in western Siberia, including the key Asian site Rostovka, with the largest number of graves containing Seima-Turbino objects. Currently, the presented database is the most extensive for the Seima-Turbino complexes. The resulting radiocarbon (14C) chronology for the western Siberian sites (22nd–20th centuries cal BC) is older than the existing chronology based on typological analysis (16th–15th centuries BC) and some earlier14C dates for the Seima-Turbino sites in eastern Europe. Another important aspect of this work is14C dating of complexes within specific bronze objects—daggers with figured handles—which some researchers have related to the Seima-Turbino type objects. These items are mostly represented by occasional finds in Central Asia, however, in western Siberia these have been recovered from burials, too. The14C dating attributes these daggers to the end of the 3rd millennium cal BC, suggesting their similar timing to the Seima-Turbino objects. Further research into freshwater reservoir offsets in the region is essential for a more reliable reconstruction of the chronology of the Seima-Turbino phenomenon and the daggers with figured handles.
La lente intégration du queer au féminisme québécois francophone: douze ans de résistance et le rôle de passeur des Panthères roses
Authors: Pagé Geneviève 
Published: June 2017

RésuméLe voyage et l'appropriation des théories queer dans les milieux féministes francophones du Québec ont été particulièrement longs et ardus, appelant un questionnement non seulement sur les raisons de ce retard, mais aussi sur les dimensions qui ont permis, ultimement, l'intégration des théories queer chez les féministes francophones. Combinant des outils analytiques en provenance de la littérature sur la diffusion des mouvements sociaux (passeurs oubrokers, cadres interprétatifs, répertoires d'action collective, etc.) et une approche en idées politiques, nous analysons l'insertion des théories queer chez les féministes en deux temps. Dans un premier temps, les intellectuelles féministes critiquent de manière assez généralisée les théories queer, critiques regroupées en 3 axes : 1) la déconstruction des femmes et des lesbiennes en tant que sujet politique ; 2) l'investissement dans l'univers symbolique du politique comme espace de subversion, au détriment des relations matérielles et des structures de pouvoir ; et 3) la disparition de la spécificité lesbienne et l'absence de remise en question des privilèges masculins dans les mouvements queer. Dans un deuxième temps, le travail de passeur des Panthères roses–groupes queer radical–permet la traduction des cadres (frame bridging) et leur inscription dans un répertoire d'action reconnaissable des féministes, répondant ainsi à deux des trois axes de critiques. Nous avançons donc que ce rôle de passeur permettra d'ouvrir une brèche qui, rapidement, permettra l'inscription et l'intégration, même si conflictuelles, du queer dans les milieux féministes francophones.
Cardiovascular fitness in late adolescent males and later risk of serious non-affective mental disorders: a prospective, population-based study
Authors: Nyberg J. , Henriksson M. , Åberg M. A. I. , Rosengren A. , Söderberg M. , Åberg N. D. , Kuhn H. G. , Waern M. 
Published: June 2017

BackgroundCardiovascular fitness in late adolescence is associated with future risk of depression. Relationships with other mental disorders need elucidation. This study investigated whether fitness in late adolescence is associated with future risk of serious non-affective mental disorders. Further, we examined how having an affected brother might impact the relationship.MethodProspective, population-based cohort study of 1 109 786 Swedish male conscripts with no history of mental illness, who underwent conscription examinations at age 18 between 1968 and 2005. Cardiovascular fitness was objectively measured at conscription using a bicycle ergometer test. During the follow-up (3–42 years), incident cases of serious non-affective mental disorders (schizophrenia and schizophrenia-like disorders, other psychotic disorders and neurotic, stress-related and somatoform disorders) were identified through the Swedish National Hospital Discharge Register. Cox proportional hazards models were used to assess the influence of cardiovascular fitness at conscription and risk of serious non-affective mental disorders later in life.ResultsLow fitness was associated with increased risk for schizophrenia and schizophrenia-like disorders [hazard ratio (HR) 1.44, 95% confidence interval (CI) 1.29–1.61], other psychotic disorders (HR 1.41, 95% CI 1.27–1.56), and neurotic or stress-related and somatoform disorders (HR 1.45, 95% CI 1.37–1.54). Relationships persisted in models that included illness in brothers.ConclusionsLower fitness in late adolescent males is associated with increased risk of serious non-affective mental disorders in adulthood.
Critical mingling and universal correlations in model binary active liquids
Authors: Bain Nicolas , Bartolo Denis 
Published: June 2017

AbstractEnsembles of driven or motile bodies moving along opposite directions are generically reported to self-organize into strongly anisotropic lanes. Here, building on a minimal model of self-propelled bodies targeting opposite directions, we first evidence a critical phase transition between a mingled state and a phase-separated lane state specific to active particles. We then demonstrate that the mingled state displays algebraic structural correlations also found in driven binary mixtures. Finally, constructing a hydrodynamic theory, we single out the physical mechanisms responsible for these universal long-range correlations typical of ensembles of oppositely moving bodies.
Observation of vortex-antivortex pairing in decaying 2D turbulence of a superfluid gas
Authors: Seo Sang Won , Ko Bumsuk , Kim Joon Hyun , Shin Y. 
Published: June 2017

AbstractIn a two-dimensional (2D) classical fluid, a large-scale flow structure emerges out of turbulence, which is known as the inverse energy cascade where energy flows from small to large length scales. An interesting question is whether this phenomenon can occur in a superfluid, which is inviscid and irrotational by nature. Atomic Bose-Einstein condensates (BECs) of highly oblate geometry provide an experimental venue for studying 2D superfluid turbulence, but their full investigation has been hindered due to a lack of the circulation sign information of individual quantum vortices in a turbulent sample. Here, we demonstrate a vortex sign detection method by using Bragg scattering, and we investigate decaying turbulence in a highly oblate BEC at low temperatures, with our lowest being ~0.5T
c
, where T
c
is the superfluid critical temperature. We observe that weak spatial pairing between vortices and antivortices develops in the turbulent BEC, which corresponds to the vortex-dipole gas regime predicted for high dissipation. Our results provide a direct quantitative marker for the survey of various 2D turbulence regimes in the BEC system.
Genetic associations for keratoconus: a systematic review and meta-analysis
Authors: Rong Shi Song , Ma Sarah Tsz Ue , Yu Xin Ting , Ma Li , Chu Wai Kit , Chan Tommy Chung Yan , Wang Yu Meng , Young Alvin L. , Pang Chi Pui , Jhanji Vishal , Chen Li Jia 
Published: June 2017

AbstractGenetic associations for keratoconus could be useful for understanding disease pathogenesis and discovering biomarkers for early detection of the disease. We conducted a systematic review and meta-analysis to summarize all reported genetic associations for the disease. We searched in the MEDLINE, Embase, Web of Science, and HuGENET databases for genetic studies of keratoconus published from 1950 to June 2016. The summary odds ratio and 95% confidence intervals of all polymorphisms were estimated using the random-effect model. Among 639 reports that were retrieved, 24 fulfilled required criteria as eligible studies for meta-analysis, involving a total of 53 polymorphisms in 28 genes/loci. Results of our meta-analysis lead to the prioritization of 8 single-nucleotide polymorphisms (SNPs) in 6 genes/loci for keratoconus in Whites. Of them 5 genes/loci were originally detected in genome-wide association studies, including FOXO1 (rs2721051, P = 5.6 × 10−11), RXRA-COL5A1 (rs1536482, P = 2.5 × 10−9), FNDC3B (rs4894535, P = 1.4 × 10−8), IMMP2L (rs757219, P = 6.1 × 10−7; rs214884, P = 2.3 × 10−5), and BANP-ZNF469 (rs9938149, P = 1.3 × 10−5). The gene COL4A4 (rs2229813, P = 1.3 × 10−12; rs2228557, P = 4.5 × 10−7) was identified in previous candidate gene studies. We also found SNPs in 10 genes/loci that had a summary P value < 0.05. Sensitivity analysis indicated that the results were robust. Replication studies and understanding the roles of these genes in keratoconus are warranted.
The impact of visual gaze direction on auditory object tracking
Authors: Pomper Ulrich , Chait Maria 
Published: June 2017

AbstractSubjective experience suggests that we are able to direct our auditory attention independent of our visual gaze, e.g when shadowing a nearby conversation at a cocktail party. But what are the consequences at the behavioural and neural level? While numerous studies have investigated both auditory attention and visual gaze independently, little is known about their interaction during selective listening. In the present EEG study, we manipulated visual gaze independently of auditory attention while participants detected targets presented from one of three loudspeakers. We observed increased response times when gaze was directed away from the locus of auditory attention. Further, we found an increase in occipital alpha-band power contralateral to the direction of gaze, indicative of a suppression of distracting input. Finally, this condition also led to stronger central theta-band power, which correlated with the observed effect in response times, indicative of differences in top-down processing. Our data suggest that a misalignment between gaze and auditory attention both reduce behavioural performance and modulate underlying neural processes. The involvement of central theta-band and occipital alpha-band effects are in line with compensatory neural mechanisms such as increased cognitive control and the suppression of task irrelevant inputs.
Boronic Acid-Modified Magnetic Fe3O4@mTiO2 Microspheres for Highly Sensitive and Selective Enrichment of N-Glycopeptides in Amniotic Fluid
Authors: Shi Zhonghua , Pu Liyong , Guo Yueshuai , Fu Ziyi , Zhao Wene , Zhu Yunxia , Wu Jindao , Wang Fuqiang 
Published: June 2017

AbstractAlthough mesoporous materials and magnetic materials are used to enrich glycopeptides, materials sharing both mesoporous structures and magnetic properties have not been reported for glycopeptide analyses. Here we prepared boronic acid-modified magnetic Fe3O4@mTiO2 microspheres by covalent binding of boronic acid molecules onto the surfaces of silanized Fe3O4@mTiO2 microspheres. The final particles (denoted as B-Fe3O4@mTiO2) showed a typical magnetic hysteresis curve, indicating superparamagnetic behavior; meanwhile, their mesoporous sizes did not change in spite of the reduction in surface area and pore volume. By using these particles together with conventional poly(methyl methacrylate) (PMMA) nanobeads, we then developed a synergistic approach for highly specific and efficient enrichment of N-glycopeptides/glycoproteins. Owing to the introduction of PMMA nanobeads that have strong adsorption towards nonglycopeptides, the number of N-glycopeptides detected and the signal-to-noise ratio in analyzing standard proteins mixture both increased appreciably. The recovery of N-glycopeptides by the synergistic method reached 92.1%, much improved than from B-Fe3O4@mTiO2 alone that was 75.3%. Finally, we tested this approach in the analysis of amniotic fluid, obtaining the maximum number and ratio of N-glycopeptides compared to the use of B-Fe3O4@mTiO2 alone and commercial SiMAG-boronic acid particles. This ensemble provides an interesting and efficient enrichment platform for glycoproteomics research.
New insights on the complex dynamics of two-phase flow in porous media under intermediate-wet conditions
Authors: Rabbani Harris Sajjad , Joekar-Niasar Vahid , Pak Tannaz , Shokri Nima 
Published: June 2017

AbstractMultiphase flow in porous media is important in a number of environmental and industrial applications such as soil remediation, CO2 sequestration, and enhanced oil recovery. Wetting properties control flow of immiscible fluids in porous media and fluids distribution in the pore space. In contrast to the strong and weak wet conditions, pore-scale physics of immiscible displacement under intermediate-wet conditions is less understood. This study reports the results of a series of two-dimensional high-resolution direct numerical simulations with the aim of understanding the pore-scale dynamics of two-phase immiscible fluid flow under intermediate-wet conditions. Our results show that for intermediate-wet porous media, pore geometry has a strong influence on interface dynamics, leading to co-existence of concave and convex interfaces. Intermediate wettability leads to various interfacial movements which are not identified under imbibition or drainage conditions. These pore-scale events significantly influence macro-scale flow behaviour causing the counter-intuitive decline in recovery of the defending fluid from weak imbibition to intermediate-wet conditions.