bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Universal Strategy to Enhance Polarization Performance and Anode Reversal Tolerance by Polyaniline‐Coated Carbon Support for Proton Exchange Membrane Fuel Cells
Authors: Li Zheng , Mu Yongbiao , Zhang Qing , Xiao Cailin , Jiang Yuting , Du Lei , Ye Siyu , Zhao Tianshou , Zeng Lin 
Published: October 2024

AbstractAnode cell reversal typically leads to severe carbon corrosion and catalyst layer collapse, which significantly compromises the durability of proton exchange membrane fuel cells. Herein, three types of commercial carbon supports with various structures are facilely coated by polyaniline (PANI) and subsequently fabricated into reversal‐tolerant anodes (RTAs). Consequently, the optimized PANI‐coated catalyst RTAs demonstrate enhanced polarization performance and improved reversal tolerance compared to their uncoated counterparts, thus confirming the universality of this coating strategy. Essentially, the surface engineering introduced by PANI coating incorporates abundant N‐groups and enhances coulombic interactions with ionomer side chains, which in turn reduces lower carbon exposure, promotes more uniform Pt deposition, and ensures better ionomer distribution. Accordingly, the membrane‐electrode‐assembly containing the Pt/PANI/XC‐72R‐1+IrO2 RTA presents a 100 mV (at 2500 mA cm−2) polarization performance improvement and 26‐fold reduction in the degradation rate compared to the uncoated counterpart. This work provides a universal strategy for developing durable anodes and lays the groundwork for the practical fabrication of high‐performance, low‐degradation RTA.
Cotton Bollworm (H. armigera) Effector PPI5 Targets FKBP17‐2 to Inhibit ER Immunity and JA/SA Responses, Enhancing Insect Feeding
Authors: Wang Yaxin , Zhu Chuanying , Chen Gefei , Li Xuke , Zhu Mingjv , Alariqi Muna , Hussian Amjad , Ma Weihua , Lindsey Keith , Zhang Xianlong , Nie Xinhui , Jin Shuangxia 
Published: October 2024

AbstractThe cotton bollworm causes severe mechanical damage to plants during feeding and leaves oral secretions (OSs) at the mechanical wounds. The role these OSs play in the invasion of plants is still largely unknown. Here, a novel H. armigera effector peptidyl prolyl trans‐isomerase 5 (PPI5) was isolated and characterized. PPI5 induces the programmed cell death (PCD) due to the unfolded protein response (UPR) in tobacco leaf. We reveal that PPI5 is important for the growth and development of cotton bollworm on plants, as it renders plants more susceptible to feeding. The GhFKBP17‐2, was identified as a host target for PPI5 with peptidyl‐prolyl isomerase (PPIase) activity. CRISPR/Cas9 knock‐out cotton mutant (CR‐GhFKBP17‐1/3), VIGS (TRV: GhFKBP17‐2) and overexpression lines (OE‐GhFKBP17‐1/3) were created and the data indicate that GhFKBP17‐2 positively regulates endoplasmic reticulum (ER) stress‐mediated plant immunity in response to cotton bollworm infestation. We further confirm that PPI5 represses JA and SA levels by downregulating the expression of JA‐ and SA‐associated genes, including JAZ3/9, MYC2/3, JAR4, PR4, LSD1, PAD4, ICS1 and PR1/5. Taken together, our results reveal that PPI5 reduces plant defense responses and makes plants more susceptible to cotton bollworm infection by targeting and suppressing GhFKBP17‐2 ‐mediated plant immunity.
Engineering Topological Spin Hall Effect in 2D Multiferroic Material
Authors: Dou Kaiying , He Zhonglin , Zhao Jiangyu , Du Wenhui , Dai Ying , Huang Baibiao , Ma Yandong 
Published: October 2024

AbstractTopological spin Hall effect (TSHE), promoted by coupling between noncoplanar spins and real‐space topology, is a significant phenomenon in condensed matter physics. However, the control of TSHE characteristics is missing due to its intrinsic robustness, and such fundamental difficulty prevents it from being used for spintronics up to now. Here, a rational design approach is demonstrated to engineer TSHE in a controllable and reversible fashion. Through symmetry and model analysis, it is unveiled that antiferromagnetic topological charge, as well as Lorentz forces, acted on conduction electrons, can be coupled with Dzyaloshinskii‐Moriya interaction chirality for antiferromagnetic bimerons in 2D multiferroic materials. Such coupling guarantees the ferroelectric control of TSHE. Using first‐principles calculations and atomic spin model simulations, the validity of this mechanism is further demonstrated in multiferroic monolayer CuCr2Se4 with experimental feasibility. The alter‐chirality of the Dzyaloshinskii‐Moriya interaction is found to play a crucial role in realizing this mechanism. This results extend TSHE to be used in spintronics and open a new direction for spintronics research.
Direct Catalytic Asymmetric Conjugate Addition of Benzofuran‐3(2H)‐Ones to α,β‐Unsaturated Thioamides: Stereodivergent Synthesis of Rocaglaol
Authors: Samanta Sadhanendu , Noda Hidetoshi , Watanabe Takumi , Cui Jin , Shibasaki Masakatsu 
Published: October 2024

AbstractRocaglaol, a representative flavagline, has attracted significant attention because of its unique chemical structure and biological activities. This paper reports a mild and scalable copper‐catalyzed enantioselective conjugate addition of benzofuran‐3(2H)‐ones to α,β‐unsaturated thioamides. This method allows for the concise synthesis of all possible stereoisomers of a key intermediate of rocaglaol and its derivatives in a highly diastereo‐ and enantioselective manner using different chiral phosphine ligands. Theoretical insights into the reaction mechanism and the origin of ligand‐dependent diastereodivergence were obtained using density functional theory calculations.
A Facile and Safe Route to Fabricate Boscalid‐Loaded ZIF‐8 Nanoparticles With Efficient Antibacterial Activity and Long‐Sustained Release
Authors: Chen Weiyan , Liu Jinxi , Zhan Yingyu , Gao Minghui , Zhang Baohua 
Published: October 2024

ABSTRACTSynthesis of ZIF‐8 mainly uses zinc nitrate hexahydrate (Zn(NO3)2.6H2O) as the zinc source. Zn (NO3)2.6H2O is flammable, explosive, and highly corrosive, posing a threat to human health. It also requires a molar ratio of 2‐methylimidazole to zinc source greater than 20, resulting in increased costs. In this work, a pH‐sensitive controlled‐release nano‐capsule of fungicide, ZIF‐8@Boscalid, was established using green zinc sources (zinc sulfate and zinc acetate) and was prepared based on metal–organic framework (ZIF‐8) for higher antifungal effect and low bio‐toxicity. The loading ratio is as high as 34%. In addition, the release of fungicide Boscalid showed pH‐sensitive response due to the weak acidic group in the ZIF structure, in which the rate of release was more rapid under acid condition (< 5). Cumulative release rates of the ZIF‐8(A)@Boscalid system and ZIF‐8(S)@Boscalid system were 76.15% and 86.22%, respectively. Meanwhile, the antifungal effect of ZIF‐8@Boscalid was 1.5 times more of that commercially available product on CI‐8 at the concentration of 300 mg/L, and the antibacterial activity values of the ZIF‐8(A)@Boscalid system and ZIF‐8(S)@Boscalid system against CJ‐8 were 84.54% and 78.65%, respectively. Furthermore, the obtained ZIF‐8@Boscalid system using the method described in this article exhibited certain UV resistance. Thus, this work not only proves that ZIF‐8@Boscalid could be used as nanoparticles platform for smart control over CJ‐8 but also has great potential effective utilization of Boscalid and achieving sustained release.
Synthesis, Characterization and Biological Activities of Tolfenamic Acid Alkaline Earth Metal Complexes
Authors: Akther Shamima , Islam Saiful , Rahman Md. Shahidur , Simol Hasina Akhter , Jamal A. H. M. Shofiul Islam Molla , Islam Dipa , Bakshi Pradip K. 
Published: October 2024

ABSTRACTSolid complexes of tolfenamic acid (tolfH) with Mg(II), Ca(II), Sr(II), and Ba(II) have been synthesized and characterized by CHN, metal contents analysis, FTIR, UV, 1H‐NMR spectroscopy, thermal (TGA, DTG, DTA, and DSC) analysis, molar conductance, powder X‐ray diffraction (XRD), and scanning electron microscopy (SEM–EDX). Based on these studies, the probable formulae for the complexes are [Mg(tolf)Cl(H2O)3].4H2O, [Ca(tolf)2(H2O)2], [Sr2(tolf)4(H2O)4], and [Ba2(tolf)4(H2O)4]. The ligand tolfenamate ion (tolf) exhibited different modes of coordination, including bidentate and chelating. The 1H‐NMR displayed the presence of tolfenamato ions in the coordination sphere, the purity and stability of the complexes in solution. The average crystallite sizes of the complexes were determined by XRD and ranged from 55 to 70 nm. SEM micrographs showed the rod‐ or plate‐like morphology of the prepared complexes. The complexes showed promising antioxidant activity in the DPPH radical scavenging method, with an IC50 value of 12–15 μg/mL. Against gram‐positive and gram‐negative bacteria, as well as fungi, the metal complexes also demonstrated significant antimicrobial activity. In the brine shrimp lethality bioassay, the metal complexes exhibited significantly highest cytotoxicity with the range of 15.25–24.57 μg/mL. All the complexes showed cytotoxicity against human cervical carcinoma HeLa cell lines, while the ligand itself did not show any cytotoxicity to these cancer cells. Furthermore, the metal complexes exhibited improved central and peripheral analgesic activity compared to tolfenamic acid.
H2O2 Self‐Supplying CaO2/POM@MOF Bimodal Nanogeneration Materials for Photothermal and Chemodynamic Synergistic Antimicrobials
Authors: Chen Na , Li Yuan , Pan Yang , Wang Haozhe , Gu Hao , Sun Yuan , Sun Tiedong 
Published: October 2024

ABSTRACTThe emergence of bacterial resistance has a negative impact on the conventional antimicrobial treatments, and research into the development of the new antimicrobial materials is of great significance. Multimodal synergistic antimicrobial materials exert better antimicrobial effects compared with a single modality. In recent years, Polyoxometalate (POM) has shown great potential in the biomedical field due to its high catalytic activity and high photothermal conversion ability. However, owing to its small surface area, its applications have been greatly limited. Herein, we designed a H2O2 self‐supplied CDT and PTT bimodal nanogeneration material (i.e., CaO2/POM@MOF) possessing a larger surface area for the treatment of the bacterial infections, in which CaO2 could release O2 and H2O2 in the weakly acidic microenvironment of bacterial infection and the dual catalytic site of POM@MOF could enhance the CDT reaction to generate ROS, resulting in the bacterial oxidative stress and the leakage of the bacterial contents, and the exposure to the NIR light generates localized high temperature that cause the rupture of bacterial cell membranes and the denaturation of their proteins. Meanwhile, the superior stability of POM@MOF can release fewer metal ions to improve its biocompatibility. The in vitro antimicrobial experiments demonstrated that CaO2/POM@MOF possessed the combined CDT and PTT effect and exhibited excellent antimicrobial efficacy. This work presents a promising strategy to combat the bacterial infections.
Kinetic investigation of the energy storage process in graphene fiber supercapacitors: Unraveling mechanisms, fabrications, property manipulation, and wearable applications
Authors: Zhang Juan , Liu Wenwen , Du Minzhi , Xu Qingli , Hung Minren , Xiang Ruifang , Liao Meng , Wang Xinhou , Wang Bingjie , Yu Aiping , Zhang Kun 
Published: October 2024

AbstractGraphene fiber supercapacitors (GFSCs) have garnered significant attention due to their exceptional features, including high power density, rapid charge/discharge rates, prolonged cycling durability, and versatile weaving capabilities. Nevertheless, inherent challenges in graphene fibers (GFs), particularly the restricted ion‐accessible specific surface area (SSA) and sluggish ion transport kinetics, hinder the achievement of optimal capacitance and rate performance. Despite existing reviews on GFSCs, a notable gap exists in thoroughly exploring the kinetics governing the energy storage process in GFSCs. This review aims to address this gap by thoroughly analyzing the energy storage mechanism, fabrication methodologies, property manipulation, and wearable applications of GFSCs. Through theoretical analysis of the energy storage process, specific parameters in advanced GF fabrication methodologies are carefully summarized, which can be used to modulate nano/micro‐structures, thereby enhancing energy storage kinetics. In particular, enhanced ion storage is realized by creating more ion‐accessible SSA and introducing extra‐capacitive components, while accelerated ion transport is achieved by shortening the transport channel length and improving the accessibility of electrolyte ions. Building on the established structure–property relationship, several critical strategies for constructing optimal surface and structure profiles of GF electrodes are summarized. Capitalizing on the exceptional flexibility and wearability of GFSCs, the review further underscores their potential as foundational elements for constructing multifunctional e‐textiles using conventional textile technologies. In conclusion, this review provides insights into current challenges and suggests potential research directions for GFSCs.
Association of health insurance coverage disruptions and breast and colorectal cancer screening
Authors: Shi Kewei Sylvia , Han Xuesong , Star Jessica , Zhao Jingxuan , Yabroff K. Robin 
Published: October 2024

ABSTRACTBackgroundHealth insurance coverage is critical for ensuring access to recommended health care in the United States. This study investigated the associations of health insurance coverage disruptions, also known as coverage churn, and receipt of breast and colorectal cancer screening.MethodsAdults who were age‐eligible and younger than 65 years (range, 50–64 years) for breast (n = 17,128 women) and colorectal (n = 32,562 individuals) cancer screening were identified from 5 years of the National Health Interview Survey. Adults were categorized into five groups based on insurance type at survey (private, public, none) and prior coverage disruptions within the past year. Screening outcomes included: (1) ever‐screened, (2) past‐year screening, and (3) guideline‐concordant screening. Separate multivariate logistic regression models were used to evaluate the associations between insurance coverage disruptions and cancer screening.ResultsAmong adults who had coverage at the time of the survey, 3.1% with private insurance and 6.5% with public insurance reported prior coverage disruptions. Individuals without health insurance coverage had the lowest level of screening. Among individuals who had private coverage, prior disruptions were associated with lower guideline‐concordant screening in adjusted analyses (breast cancer screening: adjusted prevalence ratio [aPR], 0.82; 95% confidence interval [CI], 0.75–0.89; colorectal cancer screening: aPR, 0.78; 95% CI, 0.72–0.86); among those who had public coverage, prior disruptions were also associated with lower guideline‐concordant breast cancer screening (aPR, 0.73; 95% CI, 0.60–0.89) and colorectal cancer screening (aPR, 0.84; 95% CI, 0.72–0.99).ConclusionsHealth insurance coverage disruptions were associated with lower past‐year and guideline‐concordant breast and colorectal cancer screening. The current findings underscore the importance of stable health insurance coverage to improve cancer screening and early detection when treatment is most effective.
Intracranial arteriosclerosis is not associated with cerebral amyloid deposition
Authors: Streiber Anna M. , Neitzel Julia , Nguyen Ho Phuong Thuy , Vernooij Meike W. , Bos Daniel 
Published: October 2024

AbstractBACKGROUNDIntracranial arteriosclerosis and cerebral amyloid beta (Aβ) are both involved in the etiology of Alzheimer's disease (AD) dementia, but the direct link between these two pathologies remains elusive.METHODSIn 633 participants (mean age 69 years, 51% women) from the population‐based Rotterdam Study, we quantified cerebral Aβ accumulation on amyloid positron emission tomography (PET). We assessed calcification of the intracranial internal carotid (ICAC) and vertebrobasilar arteries (VBAC) as proxies of arteriosclerosis on non‐enhanced computed tomography (CT). Using logistic and linear regression, we studied the relationship of presence, burden, and type of calcification with the presence and burden of Aβ.RESULTSWe found no associations of ICAC [odds ratio (OR): 0.85, 95% confidence interval (CI): 0.43, 1.72] or VBAC [OR: 0.59, CI: 0.26, 1.24] with cerebral Aβ. The results did not vary across ICAC subtypes.DISCUSSIONIntracranial arteriosclerosis was not associated with cerebral Aβ, underscoring their independence in the etiology of AD dementia.Highlights
Comprehensive assessment of intracranial arteriosclerosis (e.g., including subtypes).
Intracranial arteriosclerosis in different arteries and cerebral Aβ are not related.
Arteriosclerosis and Aβ likely influence Alzheimer's disease dementia independently.
Spectroscopic Detection and Theoretical Description of Spin‐Crossover Effect in Co(II)‐terpyridine System
Authors: Stefanczyk Olaf , Li Guanping , Kumar Kunal , Song Qinyu , Nakabayashi Koji , Ohkoshi Shinichi 
Published: October 2024

AbstractSpin‐crossover (SCO) effect on octahedral Co(II) centers is much rarer and less known than in the case of Fe(II) complexes, although it is no less promising for the development of fundamental research, sophisticated memories, and sensors. The representative compound [Co(terpy)2]I2 ⋅ 2H2O (terpy=2,2′:6′,2′′‐terpyridine) was synthesized, and its physicochemical properties were studied both experimentally and theoretically. Magnetic experiments revealed a very gradual SCO between a low‐spin state (SCo(II)‐LS=1/2) and a high‐spin state (SCo(II)‐HS=3/2) for the pristine sample and an abrupt SCO with a narrow thermal hysteresis around 130 K for the desolvated sample. Moreover, temperature‐dependent vibrational and electronic spectroscopy were employed to track the evolution of spectroscopic features related to SCO and desolvation processes. Additionally, quantum chemical calculations were utilized to determine the electronic structure, molecular orbitals, and vibrations for different spin states at various temperatures, offering a more comprehensive understanding of the compound's spectroscopic and magnetic behaviors. These extensive investigations provide valuable insights into Co(II)‐based SCO materials and their theoretical underpinnings, paving the way for the application of their thermometric properties.
Wheat bran: A nutritional treasure or bread‐making challenge?—A mini‐review
Authors: Li Cheng , Wu Wei 
Published: October 2024

AbstractWheat bran, a by‐product of milling, boasts a rich nutrient profile and bioactive compounds that offer significant protective effects against various metabolic syndromes and chronic diseases. Despite its high nutritional value, incorporating wheat bran into the bakery products presents challenges, particularly regarding its impact on dough rheology and bread texture and tastes, which can reduce consumer acceptability. This mini review explores the structural composition of wheat grain, the origin of bran, and their implications for dough and bread quality. Additionally, the role of wheat bran‐associated enzymes and their influence on dough and bread‐making properties are also discussed. This mini review aims to enhance understanding of the wheat bran's influence on bread quality and encourage the consumption of wheat bran‐enriched products.
Fermentative production of vitamin B12 by Propionibacterium shermanii and Pseudomonas denitrificans and its promising health benefits: A review
Authors: Tripathi Anjali , Pandey Vinay Kumar , Panesar Parmjit S. , Taufeeq Anam , Mishra Hridyanshi , Rustagi Sarvesh , Malik Sumira , Kovács Béla , Suthar Tejas , Shaikh Ayaz Mukarram 
Published: October 2024

AbstractCobalamin, generally known as vitamin B12, is a crucial component required for humans in several physiological processes. It has been produced from sources that are derived from animals, making it difficult for vegetarians and vegans to consume the recommended amount each day. The importance of vitamin B12 in red blood cell production, DNA synthesis, and brain processes has been highlighted. Recent studies have looked at different methods of producing vitamin B12, such as microbial fermentation. Propionibacterium shermanii and Pseudomonas denitrificans have demonstrated remarkable potential as fermented sources of vitamin B12. Compared to conventional sources, the bioavailability of vitamin B12 produced by P. denitrificans and P. shermanii is more effective in meeting dietary needs. Vitamin B12 can be produced naturally by P. denitrificans. It is equipped with the enzymes and metabolic pathways required to produce this vital vitamin. The fermentation of several dietary substrates by P. shermanii can improve nutrient bioavailability. P. shermanii generates enzymes during fermentation that aid in the breakdown of complex nutrients, facilitating easier absorption and utilization by the body. The motive of the following critical evaluation is to assess the advantages of vitamin B12 for health and the capacity of P. denitrificans and P. shermanii to produce it through fermentation.
The most efficient machine learning algorithms in stroke prediction: A systematic review
Authors: Asadi Farkhondeh , Rahimi Milad , Daeechini Amir Hossein , Paghe Atefeh 
Published: October 2024

AbstracBackground and AimsStroke is one of the most common causes of death worldwide, leading to numerous complications and significantly diminishing the quality of life for those affected. The purpose of this study is to systematically review published papers on stroke prediction using machine learning algorithms and introduce the most efficient machine learning algorithms and compare their performance. The papers have published in period from 2019 to August 2023.MethodsThe authors conducted a systematic search in PubMed, Scopus, Web of Science, and IEEE using the keywords “Artificial Intelligence,” “Predictive Modeling,” “Machine Learning,” “Stroke,” and “Cerebrovascular Accident” from 2019 to August 2023.ResultsTwenty articles were included based on the inclusion criteria. The Random Forest (RF) algorithm was introduced as the best and most efficient stroke ML algorithm in 25% of the articles (n = 5). In addition, in other articles, Support Vector Machines (SVM), Stacking and XGBOOST, DSGD, COX& GBT, ANN, NB, and RXLM algorithms were introduced as the best and most efficient ML algorithms in stroke prediction.ConclusionThis research has shown a rapid increase in using ML algorithms to predict stroke, with significant improvements in model accuracy in recent years. However, no model has reached 100% accuracy or is entirely error‐free. Variations in algorithm efficiency and accuracy stem from differences in sample sizes, datasets, and data types. Further studies should focus on consistent datasets, sample sizes, and data types for more reliable outcomes.