bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying Differences and Similarities in Whole-brain White Matter Architecture Using Local Connectome Fingerprints
Authors: Yeh Fang-Cheng , Vettel Jean M. , Singh Aarti , Poczos Barnabas , Grafton Scott , Erickson Kirk I. , Tseng Wen-Yih I. , Verstynen Timothy D. 
Published: March 2016

AbstractQuantifying differences or similarities in connectomes has been a challenge due to the immense complexity of global brain networks. Here we introduce a noninvasive method that uses diffusion MRI to characterize whole-brain white matter architecture as a single local connectome fingerprint that allows for a direct comparison between structural connectomes. In four independently acquired data sets with repeated scans (total N=213), we show that the local connectome fingerprint is highly specific to an individual, allowing for an accurate self-versus-others classification that achieved 100% accuracy across 17,398 identification tests. The estimated classification error was approximately one thousand times smaller than fingerprints derived from diffusivity-based measures or region-to-region connectivity patterns. The local connectome fingerprint also revealed neuroplasticity within an individual reflected as a decreasing trend in self-similarity across time, whereas this change was not observed in the diffusivity measures. Moreover, the local connectome fingerprint can be used as a phenotypic marker, revealing 12.51% similarity between monozygotic twins, 5.14% between dizygotic twins, and 4.51% between none-twin siblings. This novel approach opens a new door for probing the influence of pathological, genetic, social, or environmental factors on the unique configuration of the human connectome.Author SummaryThe local organization of white matter architecture is highly unique to individuals, making it a tangible metric of connectomic differences. The variability in local white matter architecture is found to be partially determined by genetic factors, but largely plastic across time. This approach opens a new door for probing the influence of pathological, genetic, social, or environmental factors on the unique configuration of the human connectome.
Towards a unified customer experience in online shopping environments
Authors: Bilgihan Anil , Kandampully Jay , Zhang Tingting (Christina) 
Published: March 2016

Purpose
– New developments in e-commerce and m-commerce technologies along with the wide adoption of mobile devices and social media have enabled companies to enhance customers’ shopping experiences and their interaction with brands anytime, anywhere. The purpose of this paper is to develop a theoretical model for a unified online customer experience by drawing from related literature on consumer behavior in the online contexts.

Design/methodology/approach
– By synthesizing extant consumer behavior and e-commerce literature, this paper seeks further understanding of online customer experience and offers strategies for e-commerce marketers and Web site designers.

Findings
– The findings of this paper indicate that easiness to locate the Web site/app, ease of use, perceived usefulness, hedonic and utilitarian features, perceived enjoyment, personalization, social interactions and multi-device compatibility are the antecedents of the unified online customer experience. Brand engagement, positive word of mouth (WOM) and repeat purchase are the outcomes of compelling online customer experience.

Practical implications
– A significant amount of potential revenue is lost globally due to poor online customer experiences, resulting in e-commerce not reach its potential. E-commerce companies should “hook” customers by providing compelling online experiences.

Originality/value
– Given that customer’s experience has become one of the most important and competitive outcome variable for contemporary companies, the results will benefit e-commerce marketers and Web site designers.
The impact of destination websites and cultural exposure: a comparison study of experienced and inexperienced travelers
Authors: Koo Chulmo , Chung Namho , Kim Dan J. , Hlee Sunyoung 
Published: March 2016

Purpose– As a growth of the competition between cities in Asia effective tourism marketing of the city cultural tourism product will become increasingly important. Cultural exposure to a particular foreign city through the media affects people’s preferences for that destination and may ultimately be a function of the behavior of that city cultural product. The purpose of this paper is to examine the impacts of experienced and inexperienced travelers’ media exposure and their perception of the media exposure on their intention to visit the actual site (i.e. South Korea).Design/methodology/approach– To enhance the understanding of the intention to visit the destination, this study proposes a research model based on use and gratification (U & G) theory and information system (IS) success model.Findings– The authors found a direct, positive effect of satisfaction with the Korea Tourism Organization’s website on potential travelers’ intentions to visit Korea.Research limitations/implications– First, although most measurement items were adopted from previously validated empirical studies and the results of the measurement model testing showed high reliability and validity, further study is warranted to validate the measurement scales in the context of smart tourism. Second, given the relatively small sample size, the findings of this study should not be generalized to other populations.Originality/value– The authors built a conceptual model that synthesized the IS success model and U & G theory in the context of tourism and empirically tested the model using a set of data collected from potential travelers. Overall, the proposed research model is well supported by the results of the study.
Identifying core determinants of tourism demand in Hong Kong inbound markets
Authors: Agyeiwaah Elizabeth , Adongo Raymond 
Published: March 2016

Purpose
– The purpose of this paper is to identify the core factors that determine tourism demand in four inbound markets of Hong Kong.

Design/methodology/approach
– The general-to-specific approach was adopted as a step-by-step approach to identify the major determinants of tourism demand in Hong Kong.

Findings
– The study revealed word of mouth and income of source market are core determinants of tourism demand in all four inbound markets.

Originality/value
– Knowledge of core determinants of tourism demand is useful to destination management organizations and tourism business owners for strategic planning and decision making to increase total revenues.
The mitigating effects of core self-evaluations in uncertain environments
Authors: Haynie Jeffrey J. , Harris Stanley G , Flynn Christopher Brian 
Published: March 2016

Purpose– The purpose of this paper is to examine the impact of core self-evaluations (CSE) and change uncertainty on job satisfaction and turnover intentions within the context of an organizational change. Because individuals high in CSE are expected to be able to cope better with uncertainty, the authors also tested the mitigating effect of CSE on the change uncertainty-attitude relationships.Design/methodology/approach– Surveys were completed and returned by 398 employees in the midst of a merger containing measures of CSE, change uncertainty, job satisfaction, and turnover intentions. The survey was voluntary and administered cross-sectionally.Findings– Change uncertainty was found to negatively influence job satisfaction and positively influence turnover intentions. Additionally, CSE positively impacted job satisfaction and negatively impacted turnover intentions. High CSE was also found to minimize the negative impact of examined change uncertainty-job attitude relationships.Research limitations/implications– The research has implications for the role of CSE in attitude formation within a change context and adds to existing literature supporting the detrimental effects of change uncertainty on job attitudes. Also, the study provided evidence of how CSE interacts with change uncertainty reducing the detrimental impact on job attitudes. Future research should continue to examine the role of CSE in the way employees react to other change-related stressors.Originality/value– The relationships among change uncertainty, CSE, and job attitudes were explored through a theoretical lens and tested empirically using employees in the midst of an organizational change.
Multilevel transformational leadership and management innovation
Authors: Chang Yi-Ying 
Published: March 2016

Purpose– The purpose of this paper is to extend management innovation theory and research by going beyond analysis at a single level. Focussing on management innovation at the lower level in the organizational hierarchy, the authors develop a multilevel framework; in doing so, the authors answer earlier calls for a study of the effects of multilevel transformational leadership (TFL) on management innovation and innovation in general.Design/methodology/approach– This study collected multisource and multilevel data from 169 managers, 423 employees of 141 units from 21 banking service firms in an emerging economy.Findings– The results from hierarchial linear modeling analysis reveal that unit-level TFL was positively related to unit-level management innovation. Furthermore, firm-level TFL was positively associated with firm-level empowerment climate, which in turn enhanced unit-level management innovation. In addition, firm-level empowerment climate strengthened the relationship between unit-level TFL and unit-level management innovation. Finally, the unit-level trust mediates the relationship between firm-level empowerment climate and unit-level management innovation.Practical implications– Firms operate more effectively when they generate management innovation. To help ensure the effectiveness of management innovation, it is essential that firms, especially those from the banking sector, encourage their managers to engage in TFL behaviors. The managers must consider how to utilize their TFL behaviors to create trusting relationships in order to achieve the organizational goals. Firms can also take steps to develop a supportive climate of higher levels of autonomy, delegation, freedom and task accountability, in order to promote higher levels of trust at the lower levels of the organizational hierarchy.Originality/value– The current study develops and tests a mediation model that links firm-level TFL to unit-level management innovation, and identifies unit-level trust as the intermediate outcome. With this theorizing and the findings, the authors deepen the current knowledge regarding the organizational implications of TFL behaviors for management innovation.
Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19
Authors: Fink Avner , Hassan Musa A. , Okan Nihal A. , Sheffer Michal , Camejo Ana , Saeij Jeroen P. J. , Kasper Dennis L. 
Published: March 2016

ABSTRACT

Differences among individuals in susceptibility to infectious diseases can be modulated by host genetics. Much of the research in this field has aimed to identify loci within the host genome that are associated with these differences. In mice, A/J (AJ) and C57BL/6J (B6) mice show differential susceptibilities to various pathogens, including the intracellular pathogen
Francisella tularensis
. Because macrophages are the main initial target during
F. tularensis
infection, we explored early interactions of macrophages from these two mouse strains with
F. tularensis
as well as the genetic factors underlying these interactions. Our results indicate that bacterial interactions with bone marrow-derived macrophages (BMDMs) during early stages of infection are different in the AJ and B6 strains. During these early stages, bacteria are more numerous in B6 than in AJ macrophages and display differences in trafficking and early transcriptional response within these macrophages. To determine the genetic basis for these differences, we infected BMDMs isolated from recombinant inbred (RI) mice derived from reciprocal crosses between AJ and B6, and we followed early bacterial counts within these macrophages. Quantitative trait locus (QTL) analysis revealed a locus on chromosome 19 that is associated with early differences in bacterial counts in AJ versus B6 macrophages. QTL analysis of published data that measured the differential susceptibilities of the same RI mice to an
in vivo
challenge with
F. tularensis
confirmed the
F. tularensis
susceptibility QTL on chromosome 19. Overall, our results show that early interactions of macrophages with
F. tularensis
are dependent on the macrophage genetic background.

IMPORTANCE
Francisella tularensis
is a highly pathogenic bacterium with a very low infectious dose in humans. Some mechanisms of bacterial virulence have been elucidated, but the host genetic factors that contribute to host resistance or susceptibility are largely unknown. In this work, we have undertaken a genetic approach to assess what these factors are in mice. Analyzing early interactions of macrophages with the bacteria as well as data on overall susceptibility to infection revealed a locus on chromosome 19 that is associated with both phenotypes. In addition, our work revealed differences in the early macrophage response between macrophages with different genetic backgrounds. Overall, this work suggests some intriguing links between
in vitro
and
in vivo
infection models and should aid in further elucidating the genetic circuits behind the host response to
Francisella tularensis
infection.
Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study)
Authors: Onozuka Daisuke , Hagihara Akihito , Nishimura Kunihiro , Kada Akiko , Nakagawara Jyoji , Ogasawara Kuniaki , Ono Junichi , Shiokawa Yoshiaki , Aruga Toru , Miyachi Shigeru , Nagata Izumi , Toyoda Kazunori , Matsuda Shinya , Suzuki Akifumi , Kataoka Hiroharu , Nakamura Fumiaki , Kamitani Satoru , Nishimura Ataru , Kurogi Ryota , Sayama Tetsuro , Iihara Koji ,   the J-ASPECT Study Collaborators
Published: March 2016

ObjectivesTo elucidate the association between antiplatelet use in patients with non-haemorrhagic moyamoya disease before hospital admission and good functional status on admission in Japan.DesignRetrospective, multicentre, non-randomised, observational study.SettingNationwide registry data in Japan.ParticipantsA total of 1925 patients with non-haemorrhagic moyamoya disease admitted between 1 April 2012 and 31 March 2014 in Japan.Main outcome measureWe performed propensity score-matched analysis to examine the association between prehospital antiplatelet use and no significant disability on hospital admission, as defined by a modified Rankin Scale score of 0 or 1.ResultsPropensity-matched patients who received prehospital antiplatelet drugs were associated with a good outcome on hospital admission (OR adjusted for all covariates, 3.82; 95% CI 1.22 to 11.99) compared with those who did not receive antiplatelet drugs prior to hospital admission.ConclusionsPrehospital antiplatelet use was significantly associated with good functional status on hospital admission among patients with non-haemorrhagic moyamoya disease in Japan. Our results suggest that prehospital antiplatelet use should be considered when evaluating outcomes of patients with non-haemorrhagic moyamoya disease.
Cross-sectional study of diet, physical activity, television viewing and sleep duration in 233 110 adults from the UK Biobank; the behavioural phenotype of cardiovascular disease and type 2 diabetes
Authors: Cassidy Sophie , Chau Josephine Y , Catt Michael , Bauman Adrian , Trenell Michael I 
Published: March 2016

ObjectivesSimultaneously define diet, physical activity, television (TV) viewing, and sleep duration across cardiometabolic disease groups, and investigate clustering of non-diet lifestyle behaviours.DesignCross-sectional observational study.Setting22 UK Biobank assessment centres across the UK.Participants502 664 adults aged 37–63 years old, 54% women. 4 groups were defined based on disease status; ‘No disease’ (n=103 993), ‘cardiovascular disease’ (CVD n=113 469), ‘Type 2 diabetes without CVD’ (n=4074) and ‘Type 2 diabetes + CVD’ (n=11 574).Main outcomesDiet, physical activity, TV viewing and sleep duration.ResultsPeople with ‘CVD’ report low levels of physical activity (<918 MET min/week, OR (95% CI) 1.23 (1.20 to 1.25)), high levels of TV viewing (>3 h/day; 1.42 (1.39 to 1.45)), and poor sleep duration (<7, >8 h/night; 1.37 (1.34 to 1.39)) relative to people without disease. People with ‘Type 2 diabetes + CVD’ were more likely to report low physical activity (1.71 (1.64 to 1.78)), high levels of TV viewing (1.92 (1.85 to 1.99)) and poor sleep duration (1.52 (1.46 to1.58)) relative to people without disease. Non-diet behaviours were clustered, with people with ‘CVD’ or ‘Type 2 diabetes + CVD’ more likely to report simultaneous low physical activity, high TV viewing and poor sleep duration than those without disease (2.15 (2.03 to 2.28) and 3.29 (3.02 to 3.58), respectively). By contrast, 3 in 4 adults with ‘Type 2 diabetes’, and 2 in 4 adults with ‘CVD’ have changed their diet in the past 5 years, compared with only 1 in 4 in the ‘No disease’ group. Models were adjusted for gender, age, body mass index, Townsend Deprivation Index, ethnicity, alcohol intake, smoking and meeting fruit/vegetable guidelines.ConclusionsLow physical activity, high TV and poor sleep duration are prominent unaddressed high-risk characteristics of both CVD and type 2 diabetes, and are likely to be clustered together.
Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor
Authors: Osgood Christy L. , Maloney Nichole , Kidd Christopher G. , Kitchen-Goosen Susan , Segars Laura , Gebregiorgis Meti , Woldemichael Girma M. , He Min , Sankar Savita , Lessnick Stephen L. , Kang Min , Smith Malcolm , Turner Lisa , Madaj Zachary B. , Winn Mary E. , Núñez Luz-Elena , González-Sabín Javier , Helman Lee J. , Morís Francisco , Grohar Patrick J. 
Published: March 2016

Abstract
Purpose: The goal of this study was to identify second-generation mithramycin analogues that better target the EWS-FLI1 transcription factor for Ewing sarcoma. We previously established mithramycin as an EWS-FLI1 inhibitor, but the compound's toxicity prevented its use at effective concentrations in patients.
Experimental Design: We screened a panel of mithralogs to establish their ability to inhibit EWS-FLI1 in Ewing sarcoma. We compared the IC50 with the MTD established in mice to determine the relationship between efficacy and toxicity. We confirmed the suppression of EWS-FLI1 at the promoter, mRNA, gene signature, and protein levels. We established an improved therapeutic window by using time-lapse microscopy to model the effects on cellular proliferation in Ewing sarcoma cells relative to HepG2 control cells. Finally, we established an improved therapeutic window using a xenograft model of Ewing sarcoma.
Results: EC-8105 was found to be the most potent analogue and was able to suppress EWS-FLI1 activity at concentrations nontoxic to other cell types. EC-8042 was substantially less toxic than mithramycin in multiple species but maintained suppression of EWS-FLI1 at similar concentrations. Both compounds markedly suppressed Ewing sarcoma xenograft growth and inhibited EWS-FLI1 in vivo.
Conclusions: These results provide a basis for the continued development of EC-8042 and EC-8105 as EWS-FLI1 inhibitors for the clinic. Clin Cancer Res; 22(16); 4105–18. ©2016 AACR.
Is There a Future for AKT Inhibitors in the Treatment of Cancer?
Authors: Jansen Valerie M. , Mayer Ingrid A. , Arteaga Carlos L. 
Published: March 2016

AbstractAn AKT inhibitor plus an antiestrogen exhibited no significant clinical activity in patients with ER+/HER2− breast cancer despite laboratory studies supporting an antitumor effect for both drugs combined. These results raise concerns about the development of AKT inhibitors in unselected patients whose tumors have unknown dependence on the PI3K/AKT pathway. Clin Cancer Res; 22(11); 2599–601. ©2016 AACR.See related article by Ma et al., p. 2650
Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes
Authors: Forero Andres , Li Yufeng , Chen Dongquan , Grizzle William E. , Updike Katherine L. , Merz Natalie D. , Downs-Kelly Erinn , Burwell Todd C. , Vaklavas Christos , Buchsbaum Donald J. , Myers Richard M. , LoBuglio Albert F. , Varley Katherine E. 
Published: March 2016

Abstract
Triple-negative breast cancer (TNBC) is a subtype with heterogeneous patient outcomes. Approximately 40% of patients experience rapid relapse, while the remaining patients have long-term disease-free survival. To determine if there are molecular differences between primary tumors that predict prognosis, we performed RNA-seq on 47 macrodissected tumors from newly diagnosed patients with TNBC (n = 47; 22 relapse, 25 no relapse; follow-up median, 8 years; range, 2–11 years). We discovered that expression of the MHC class II (MHC II) antigen presentation pathway in tumor tissue was the most significant pathway associated with progression-free survival (HR, 0.36; log-rank P = 0.0098). The association between MHC II pathway expression and good prognosis was confirmed in a public gene expression database of 199 TNBC cases (HR, 0.28; log-rank P = 4.5 × 10–8). Further analysis of immunohistochemistry, laser-capture microdissected tumors, and TNBC cell lines demonstrated that tumor cells, in addition to immune cells, aberrantly express the MHC II pathway. MHC II pathway expression was also associated with B-cell and T-cell infiltration in the tumor. Together, these data support the model that aberrant expression of the MHC II pathway in TNBC tumor cells may trigger an antitumor immune response that reduces the rate of relapse and enhances progression-free survival. Cancer Immunol Res; 4(5); 390–9. ©2016 AACR.
Parques urbanos: fragilidade na aplicação de legislação específica no município de Chapecó-SC
Authors: Favaretto Angela , Rammé Juliana , Afonso Sonia 
Published: March 2016

Objetivou-se investigar a relação entre a legislação federal, os Planos Diretores aprovados em Chapecó entre os anos de 1990 e 2014 e os parques urbanos, buscando compreender as diretrizes e as ações para a implantação destes. Foram utilizados métodos qualitativos: pesquisa bibliográfica e de campo com análise de conteúdo e análise histórico-estrutural, com apoio do Sistema de Informações Geográficas (SIG). Identificou-se que, nesse período, foram aprovados dois Planos Diretores (1990 e 2004) e que em ambos são estudadas áreas ambientais destinadas ao lazer. No entanto, somente em 2004 foram incluídos os parques como diretrizes e estratégias ambientais. No tocante aos mesmos, considera-se que os Planos Diretores não foram implementados e tampouco tem havido a gestão e a fiscalização do uso e da ocupação do solo. Detectaram-se, ainda, divergências entre a redação das leis dos Planos Diretores e os mapas temáticos anexos, em função das modificações realizadas por meio de leis complementares, sobretudo no que diz respeito ao gravame dos parques.