bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sacral nerve stimulation versus intravesical botulinum toxin injections for medically refractory overactive bladder: A contemporary review of UK treatment from both clinician and patients’ perspectives
Authors: Nobrega R , Greenwell TJ , Pickard R , Ockrim JL , Harding CK 
Published: December 2017

Introduction: In the UK, 10,000 refractory overactive bladder patients per year receive intravesical onabotulinum toxin A treatment and 300 receive sacral nerve stimulation implants. Current National Institute for Health and Care Excellence guidelines propose using onabotulinum toxin A before sacral nerve stimulation whilst the European Association of Urology (EAU) and American Urological Association (AUA) suggests both be offered with equipoise. The aim of this study was to ascertain both patients and clinician views regarding these two treatments. Subjects/methods: Fifty consecutive overactive bladder patients who were refractory to behavioural and medical therapy anonymously completed a structured questionnaire about their treatment preferences. Additionally, 100 UK consultant urologists anonymously completed a separate questionnaire about their treatment preferences and which treatment modalities they had available for use in their Trusts. Results: Of patients, 60% preferred sacral nerve stimulation over onabotulinum toxin A, of whom 80% would happily randomise into a trial between the two treatments. Ninety-seven per cent of 100 consultant urologists in the UK have access to onabotulinum toxin A in their hospitals, but only 39% have access to sacral nerve stimulation. Of clinicians given access to all available options, 71% would use onabotulinum toxin A as their first choice treatment for refractory overactive bladder. Conclusion: There appears to be a significant disparity between current UK overactive bladder guidance, National Health Service accessibility to onabotulinum toxin A and sacral nerve stimulation therapies, the views of clinicians, and patient preferences for treatment. Level of evidence: 5
Hoffa Fragments in the Geriatric Distal Femur Fracture: Myth or Reality?
Authors: Hill Brian W. , Cannada Lisa K. 
Published: December 2017

Background: Previous research reported the frequency of coronal plane (Hoffa) fractures in high-energy supracondylar femur fractures in a relatively young population. It is the purpose of this study to identify the frequency of coronal plane fractures seen in elderly patients. Methods: All patients over the age of 18 years treated for supracondylar femur fractures at 2 level I trauma centers were reviewed over a 4-year period. The patients were stratified (≥60 years and <60 years) and compared to determine differences in injury characteristics and fracture patterns with special attention to the prevalence of coronal plane fractures. Results: One hundred ten patients were identified with supracondylar femur fractures (12 Orthopaedic Trauma Association [OTA] 33A; 2 OTA 33B; 96 OTA 33C). Thirty-two of the 96 intercondylar fractures were in patients >60 years of age. The elderly group included a higher percentage of females (81% vs 36%, P = .0001) and was more likely to sustain their injury due to a fall (59% vs 19%, P = .0001). Coronal plane fractures were visualized on computed tomography scans in 56 (58%) of the 96 33C femur fractures. Forty-four percent of elderly patients sustained a coronal plane fracture compared with 66% of the younger cohort ( P = .04). The percentage of open fractures (30% elderly vs 46%) was not significantly different between the 2 groups ( P = .17). Conclusions: The occurrence rate of 44% in this study was higher than expected and is the first to provide this information in the elderly patients on this fracture. It is important that a high index of suspicion be maintained for the Hoffa fracture in all distal femur fractures, regardless of age or mechanism of injury.
Predictors of Entering a Hearing Aid Evaluation Period: A Prospective Study in Older Hearing-Help Seekers
Authors: Pronk Marieke , Deeg Dorly J.H. , Versfeld Niek J. , Heymans Martijn W. , Naylor Graham , Kramer Sophia E. 
Published: December 2017

This study aimed to determine the predictors of entering a hearing aid evaluation period (HAEP) using a prospective design drawing on the health belief model and the transtheoretical model. In total, 377 older persons who presented with hearing problems to an Ear, Nose, and Throat specialist ( n = 110) or a hearing aid dispenser ( n = 267) filled in a baseline questionnaire. After 4 months, it was determined via a telephone interview whether or not participants had decided to enter a HAEP. Multivariable logistic regression analyses were applied to determine which baseline variables predicted HAEP status. A priori, candidate predictors were divided into ‘likely’ and ‘novel’ predictors based on the literature. The following variables turned out to be significant predictors: more expected hearing aid benefits, greater social pressure, and greater self-reported hearing disability. In addition, greater hearing loss severity and stigma were predictors in women but not in men. Of note, the predictive effect of self-reported hearing disability was modified by readiness such that with higher readiness, the positive predictive effect became stronger. None of the ‘novel’ predictors added significant predictive value. The results support the notion that predictors of hearing aid uptake are also predictive of entering a HAEP. This study shows that some of these predictors appear to be gender specific or are dependent on a person’s readiness for change. After assuring the external validity of the predictors, an important next step would be to develop prediction rules for use in clinical practice, so that older persons’ hearing help-seeking journey can be facilitated.
‘‘POLYGNOSIS’’: the development of a thesaurus in an Educational Web Platform on optical and laser-based investigation methods for cultural heritage analysis and diagnosis
Authors: Platia Nikoleta , Chatzidakis Maria , Doerr Corina , Charami Lida , Bekiari Chrysoula , Melessanaki Kristalia , Hatzigiannakis Kostas , Pouli Paraskevi 
Published: December 2017

Abstract
Due to their unique properties, laser and optical technologies hold today an important role in the protection and study of Cultural Heritage, since they are used in a wide range of demanding analytical and diagnostic applications. Considering the rapid and vast technological development of their methodologies and tools, it is necessary to make this new knowledge more reachable and comprehensible to heritage scientists. Towards this end, a web-based knowledge platform (Polygnosis) (http://politeia.iesl.forth.gr/polygnosis/) was designed by the Institute of Computer Science (ICS) of FORTH concerning the state-of-the-art light and/or laser-based techniques, which have been developed at the Institute of Electronic Structure and Lasers (IESL) of FORTH, for advanced imaging, analysis and diagnosis of Cultural Heritage objects. This educational digital tool seeks to highlight the efficiency and potentials of modern optical and laser technologies in Cultural Heritage documentation, as well as, promote the dissemination and deeper understanding of their applications to conservators, archaeologists, art historians, material and laser scientists. “Polygnosis” represents accumulated knowledge regarding the selection of the diagnostic tool and the suggested methodology, with simultaneous display of examples of actual experimental procedures. The model relates those examples with the relevant terminology of the Thesaurus, the information about the object under examination and the metadata resulting from those experiments. ‘Polygnosis’ thesaurus is a semantically structured vocabulary organized by a faceted classification, which serves the educational needs of the system. The current study concerns the definition and classification of terms for the development of the semantically linked Thesaurus, as well as, the presentation and review of the knowledge platform, with emphasis on the supportive role of the thesaurus in such an educational resource.
Patient Age–Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer
Authors: Shen Xiaopei , Zhu Guangwu , Liu Rengyun , Viola David , Elisei Rossella , Puxeddu Efisio , Fugazzola Laura , Colombo Carla , Jarzab Barbara , Czarniecka Agnieszka , Lam Alfred K. , Mian Caterina , Vianello Federica , Yip Linwah , Riesco-Eizaguirre Garcilaso , Santisteban Pilar , O’Neill Christine J. , Sywak Mark S. , Clifton-Bligh Roderick , Bendlova Bela , Sýkorová Vlasta , Xing Mingzhao 
Published: December 2017

Purpose For the past 65 years, patient age at diagnosis has been widely used as a major mortality risk factor in the risk stratification of papillary thyroid cancer (PTC), but whether this is generally applicable, particularly in patients with different BRAF genetic backgrounds, is unclear. The current study was designed to test whether patient age at diagnosis is a major mortality risk factor. Patients and Methods We conducted a comparative study of the relationship between patient age at diagnosis and PTC-specific mortality with respect to BRAF status in 2,638 patients (623 men and 2,015 women) with a median age of 46 years (interquartile range, 35 to 58 years) at diagnosis and a median follow-up time of 58 months (interquartile range, 26 to 107 months). Eleven medical centers from six countries participated in this study. Results There was a linear association between patient age and mortality in patients with BRAF V600E mutation, but not in patients with wild-type BRAF, in whom the mortality rate remained low and flat with increasing age. Kaplan-Meier survival curves rapidly declined with increasing age in patients with BRAF V600E mutation but did not decline in patients with wild-type BRAF, even beyond age 75 years. The association between mortality and age in patients with BRAF V600E was independent of clinicopathologic risk factors. Similar results were observed when only patients with the conventional variant of PTC were analyzed. Conclusion The long-observed age-associated mortality risk in PTC is dependent on BRAF status; age is a strong, continuous, and independent mortality risk factor in patients with BRAF V600E mutation but not in patients with wild-type BRAF. These results question the conventional general use of patient age as a high-risk factor in PTC and call for differentiation between patients with BRAF V600E and wild-type BRAF when applying age to risk stratification and management of PTC.
Inclusión social de actores del conflicto armado colombiano: retos para la educación superior
Authors: Pachón Muñoz William 
Published: December 2017

El artículo plantea la discusión del proceso de reintegración a la vida social y económica de excombatientes del conflicto armado interno en Colombia y el papel de la educación superior. Para ello, desde la perspectiva de la educación inclusiva, aborda elementos conceptuales, jurídicos y políticos que han comprendido los procesos de desmovilización, desarme, reinserción y reintegración acaecidos en Colombia durante las últimas tres décadas y su relación con las instituciones de educación superior (ies). Concluye que la universidad debe contrarrestar barreras de orden político, económico y psicosocial a fin de garantizar procesos de inclusión social efectiva en un escenario de posconflicto en Colombia.
La Confederación Anticomunista Latinoamericana. Las conexiones civiles y militares entre Guatemala y Argentina (1972-1980)
Authors: Rostica Julieta 
Published: December 2017

El ejercicio de la represión política en las zonas urbanas en Argentina y Guatemala desde mediados de los años setenta hasta mediados de los años ochenta, específicamente la desaparición forzada de personas, presenta varias similitudes. Nuestra hipótesis es que dichas similitudes se explican por la colaboración argentina en la lucha contrasubversiva en Guatemala a los órganos vertebrales que producen la desaparición forzada, como la inteligencia civil y militar. A nuestro juicio, la transferencia de recursos, conocimientos y experiencias de Argentina hacia Guatemala se realizó no solamente a través de canales diplomáticos y oficiales, sino también a través de las conexiones civiles y militares (secretas, informales y clandestinas), como la red transnacional de extrema derecha denominada Confederación Anticomunista Latinoamericana (cal). En este artículo nos propusimos mostrar una de las condiciones de posibilidad para esa transferencia de recursos: la participación de la extrema derecha guatemalteca en la red latinoamericana de la cal y sus conexiones con Argentina. Para ello utilizamos, sobre todo, documentos desclasificados del Archivo Histórico de la Cancillería Argentina y del Centro de Documentación y Archivo para la Defensa de los Derechos Humanos de Paraguay.
Aproximación teórica y conceptual para el análisis de la Alianza del Pacífico
Authors: Chaves García Carlos Alberto 
Published: December 2017

En el marco de los recientes procesos de regionalización que vive América Latina como respuesta a la creciente multipolaridad e interdependencia que identifican el escenario global contemporáneo se configura un nuevo mapa de la integración regional que retoma y cuestiona los paradigmas tradicionales de inserción internacional. La Alianza del Pacífico (AP) se destaca como proyecto regional novedoso heredero del regionalismo abierto, con rasgos específicos que le imprimen una identidad propia aún en construcción. El objetivo del artículo es identificar las continuidades y las rupturas que evidencia la ap frente al regionalismo abierto como su marco teórico-conceptual inspirador. Se concluye que la ap se configura en sus pocos años de existencia como un proceso distinto de experiencias previas de regionalismo abierto en América Latina, con rasgos específicos que no permiten reducir la comprensión de este actor regional a un estudio de caso típico del enfoque del regionalismo abierto.
Ni aquí ni allá: Nociones de hogar y sentido de pertenencia en el contexto de la migración.
Authors: Gomez Ricardo 
Published: December 2017

La pregunta ¿dónde queda el hogar? es difícil, especialmente para los migrantes, quienes viven en un lugar diferente a su lugar de origen. Es particularmente difícil para aquellos que no tienen documentos y por lo tanto no tienen ni reconocimiento legal ni derechos, y están en constante riesgo de ser detenidos y deportados. A través de fotografía participativa y entrevistas, proceso que se ha llamado fotohistorias, se exploran experiencias humanas relacionadas con la migración en ee.uu., y en la frontera entre este y México. El artículo trata sobre las nociones contrapuestas relacionadas con el hogar y el sentido de pertenencia que surgieron en las experiencias compartidas por migrantes en estos dos contextos. Los migrantes evidenciaron diferentes nociones de “hogar” así como de “pertenencia”, que reflejan los diferentes grados de transitoriedad e impermanencia en su cotidianidad.
Nursing and the barriers to sustainable health care: a literature review
Authors: Griggs Chloe , Fernandez Ana , Callanan Margie 
Published: December 2017

Objectives: global warming poses a serious threat to human health, yet healthcare organisations and staff have been relatively slow to engage with sustainable healthcare practices. This review of the literature seeks to frame what is already known about nurses and their views on global warming and sustainable health care. Design: 11 primary research articles were sourced from a search of five mainstream databases. These articles were subject to a basic thematic analysis. Results: six themes were identified: sustainability, endemic blindness to global issues, environmental numbness, social norms, priority assigned to sustainability, and psychology of responsibility and blame. Conclusion: from the literature reviewed, there are a number of social, cultural and psychological barriers that have led to widespread inaction. This article recommends further research to understand the psychological barriers in more depth as this is a poorly understood area.
Mild bleeding disorders: what every clinician should know
Authors: Hussein HK , Nicolson PLR , Fordwor K , Lowe GC 
Published: December 2017

Patients with mild bleeding disorders are under-recognized and frequently present to general physicians. The underlying reasons for bleeding are multifactorial. There is little evidence to guide diagnostic and management decision making in patients with mild bleeding disorders.This article outlines different types of mild bleeding disorders, with a particular focus on bleeding associated with low levels of von Willebrand factor and mild platelet defects. It gives practical, evidence-based advice on the investigation and management of patients with a suspected or known mild bleeding disorder, considering the scenarios of an acute bleed, stable outpatient, peri-surgical management and thrombosis.Patients with a mild bleeding disorder have variable bleeding because of the interplay of genetic and environmental factors. The clinical history remains of utmost importance in their general management. Liaison with a specialist centre, multidisciplinary assessment and a careful judgement of the balance of risk in each individual circumstance is required to safely manage these patients.
MUSINT II: A Complex Project on a Virtual and Interactive Museum Involving Institutions of Florence, Rome and Heraklion
Authors: Jasink Anna Margherita , Faralli Cristian , Kruklidis Panaiotis 
Published: December 2017

MUSINT II is part of a bigger project involving a series of virtual and interactive museums, using traditional and new technologies with the aim to reach an enlarged audience. The presence of Archaeologists, Architects/Designers and Computer Scientists ensures an interdisciplinary methodology that makes our project rich of solutions and attractive to different visitors. MUSINT II uses a sophisticated structure, a series of 3 dimensional models produced both with photogrammetry and laser scanner. A complex database with numerous interconnected queries is implemented in order to enhance the study of a large number of objects giving really innovatory answers and effortless data processes. New hyper-realistic techniques are used to best illustrate the reconstruction of buildings, objects and scenes of life. A specific educational section is directed to young people where all these new techniques are applied in a winning way. The main object of MUSINT II consists in a specific category of small objects: sealings and seals coming from the excavations at Haghia Triada carried out by the Italian Archaeological expedition in Crete at the beginning of 1900. Our purpose is to offer a new analytic and, at the same time, a synthetic vision, opened to a large audience, of the historical-archaeological representation of one of the most important sites of Minoan Crete.
Archiving Archaeological Research Data - On Requirements, Objectives and First Experiences from a German Respectively Saxon Point of View
Authors: Göldner Reiner 
Published: December 2017

Preserving digital data over long times is an ambitious task. While most analogue documents are best stored without touching them, digital data need permanent care and curation. Regarding some differences between analogue and digital data - lifecycle, complexity, functionality and so on - it can be realized, that digital archiving is a new challenge.This paper will deal with requirements and objectives on archiving archaeological research data, as discussed in a working group of the Association of State Archaeologists in Germany (Verband der Landesarchäologen in Deutschland – VLA). Interesting themes of that discussions were “Archive Objectives”, “Worthiness of Archiving”, “Suitability of Archiving” and “Future Use Scenarios”. This paper will also deal with first experiences in building up a digital archive for archaeological research data in Saxony. This archive follows principles of “Open Archival Information System” (OAIS). It is based on professional software that has to be adapted to the special requirements of archaeological data like e.g. excavation documentation. OAIS defines six complex functions to be performed, e.g. data management and preservation planning. Preservation strategies are presented to give an idea on how to preserve content and function of archive material while systems are changing over time. This is an alternative to the idea, knowing file formats will solve all preservation problems.Archiving is the most intensive and most expensive way to store data. But aren’t there any alternatives? This paper will address some small steps leading towards a proper archiving without using large budgets. Going such steps will help to reduce the risk of losing important digital information. Going these steps will also bridge the gap until proper preservation tools will be available at a reasonable price.This article may be helpful for archaeologists that are about to build up an archive to preserve digital data for long terms. The presented concept of preservation strategies may be of interest for specialists on digital archiving.
The Ruspoli Chapel at the Porte Sante Cemetery in Florence. Material and diagnostic survey for conservation
Authors: Ciuffreda Anna Livia , Juarez Alonso Elena , Patti Petronilla , Soldaini Sara 
Published: December 2017

Porte Sante is one of the monumental cemetery in Florence, located within the fortified bastion of the Basilica di San Miniato al Monte. In the 1840s the town council decided to find a large area near Florence, to use as a cemetery. It was chosen the Fortress of San Miniato for the solemnity of the place. The first project was entrusted to Niccolò Matas in 1844 and in the 1860s the architect Mariano Falcini designed a new project using the area of the sixteenth-century fortress that stretched around the church.The Porte Sante cemetery surprised visitors with its comingling of styles: it was important to appear, to show the dignity of their own social class. This eclectic mix reveals interesting monuments for the style, for materials and construction methods. One of this examples is the Ruspoli chapel, designed in 1891 by Giovanni Paciarelli, architect sensitive to modernism and designer of Paggi Palace in Florence. The chapel, commissioned by Valsè-Pontellini family, stands out in the landscape for the precious texture of exotic carvings and inlays of polychrome marble, mosaics and historiated glass. Today it is in bad state of conservation.Today it is in bad state of conservation. The recovery of the chapel must provide for a careful restoration project whose foundation is the comprehensive knowledge of good, which can be achieved through the survey operations, the historical analysis and diagnostic investigations. The use of a photogrammetry software allowed us to obtain a virtual 3D model, which forms the basis for subsequent analyzes and evaluations on the state of conservation of the building. Such study will be applied to other artifacts in the cemetery, by implementing current and future studies on the whole complex of the Porte Sante.