bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silver Nanowires@Mn3O4 Core–Shell Nanocables as Advanced Electrode Materials for Aqueous Asymmetric Supercapacitors
Authors: Gao Zhen , Wang Heng , Cao Zhen , Zhou Tingting , An Cuihua , Zhao Yunfeng 
Published: June 2017

AbstractHigh‐electrical‐conductivity silver nanowire (AgNW)@Mn3O4 nanocables are prepared by facile chemical precipitation and subsequent thermal treatment; these treatments are environmentally friendly, low cost, and easy for mass production. The obtained Mn3O4 nanoparticles (20–30 nm) possess many interparticle mesoporous structures. The AgNW‐supported Mn3O4 nanoparticles allow for a large exposed electroactive area, rapid ion and electron transport, and robust structural stability. In addition, it is shown that the AgNWs play a positive role in the electrochemical properties of the Mn3O4 electrode used in a supercapacitor. The AgNW@Mn3O4 electrode delivers ultrahigh specific capacitances of 203 and 111 F g−1 at 0.25 and 2 A g−1, respectively. When matched with the activated carbon (AC) anode, the AgNW@Mn3O4//AC asymmetric supercapacitor (ASC) device has a wide voltage window of 1.8 V, a specific capacitance of 105 F g−1 at 1 A g−1, and 94 % capacitance conservation after 5000 cycles. Moreover, the aqueous ASC device exhibits an energy density of 28 Wh kg−1 (power density of 320 W kg−1), and maintains a value of 10 Wh kg−1 as the power density increases to 9500 W kg−1, demonstrating potential for applications.
Engaging Ly‐6A/Sca‐1 triggers lipid raft‐dependent and ‐independent responses in CD4+ T‐cell lines
Authors: Lang Melissa A. , Jenkins Sultan A. , Balzano Phillip , Owoyele Adeyinka , Patel Akshay , Bamezai Anil K. 
Published: June 2017

AbstractIntroductionThe lymphocyte antigen 6 (Ly‐6) supergene family encodes proteins of 12–14 kda in molecular mass that are either secreted or anchored to the plasma membrane through a glycosyl‐phosphatidylinisotol (GPI) lipid anchor at the carboxy‐terminus. The lipidated GPI‐anchor allows localization of Ly‐6 proteins to the 10–100 nm cholesterol‐rich nano‐domains on the membrane, also known as lipid rafts. Ly‐6A/Sca‐1, a member of Ly‐6 gene family is known to transduce signals despite the absence of transmembrane and cytoplasmic domains. It is hypothesized that the localization of Ly‐6A/Sca‐1 with in lipid rafts allows this protein to transduce signals to the cell interior.Methods and ResultsIn this study, we found that cross‐linking mouse Ly‐6A/Sca‐1 protein with a monoclonal antibody results in functionally distinct responses that occur simultaneously. Ly‐6A/Sca‐1 triggered a cell stimulatory response as gauged by cytokine production with a concurrent inhibitory response as indicated by growth inhibition and apoptosis. While production of interleukin 2 (IL‐2) cytokine by CD4+ T cell line in response to cross‐linking Ly‐6A/Sca‐1 was dependent on the integrity of lipid rafts, the observed cell death occurred independently of it. Growth inhibited CD4+ T cells showed up‐regulated expression of the inhibitory cell cycle protein p27kip but not of p53. In addition, Ly‐6A/Sca‐1 induced translocation of cytochrome C to the cytoplasm along with activated caspase 3 and caspase 9, thereby suggesting an intrinsic apoptotic cell death mechanism.ConclusionsWe conclude that opposing responses with differential dependence on the integrity of lipid rafts are triggered by engaging Ly‐6A/Sca‐1 protein on the membrane of transformed CD4+ T cells.
MRI‐based Sensors for In Vivo Imaging of Metal Ions in Biology
Authors: Allouche‐Arnon Hyla , Tirukoti Nishanth D. , Bar‐Shir Amnon 
Published: June 2017

AbstractAlthough much is known about the diverse roles of metal ions in biology, most of the acquired knowledge was obtained with fluorescent dyes or electrophysiological approaches. However, the ability to non‐invasively monitor variation in metal ions and to assess their physiological distribution in health and disease is very limited. Recent advances in the field of molecular magnetic resonance imaging (MRI) have offered new capabilities through the design and development of MRI‐responsive sensors for a wide range of applications, including the ability to sense and spatially map metal ions. Here, we briefly summarize the recent progress in the development and performance of MRI sensors designed to monitor metal ions in biology while emphasizing their in vivo uses, their limitations, and remaining challenges. Among the proposed MRI‐sensors, Zn2+ and Ca2+ responsive agents are those that have already been used in live intact subjects, and therefore, these will be emphasized here.
Implementation of a fluorescence based PAT control for fouling of protein A chromatography resin
Authors: Pathak Mili , Rathore Anurag S 
Published: June 2017

AbstractBACKGROUNDProtein A chromatography fouling is accompanied by two major events, one is the loss of protein A ligands and other is fouling due to non‐specific, irreversible interactions of foulants with resin particles. This paper presents implementation of process analytical technology based control for fouling of protein A chromatography resin using a novel, fluorescence based approach. This approach enables direct, in situ measurement of protein A ligand density as well as monitoring of resin fouling during resin reuse.RESULTSA novel, fluorescence based process analytical technology (PAT) tool has been designed and used for screening a variety of cleaning protocols. A two‐step cleaning protocol was created using this methodology. The above mentioned fluorescence based approach was successfully used to monitor fouling and to take a decision on when to initiate cleaning. This resulted in effective maintenance of dynamic binding capacity and step yield at 50 cycles (DBC: 97% of the original value vs 65% with conventional protocols and yield: 93% of the original value vs 73% with conventional protocols) and at 200 cycles (> 90% of the original value).CONCLUSIONSThe proposed fluorescence based approach has been effectively used for monitoring and control of resin fouling upon reuse, thereby resulting in a substantial increase in resin lifetime. © 2017 Society of Chemical Industry
Teleultrasound: How Accurate Are We?
Authors: Rabie Nader Z. , Sandlin Adam T. , Barber Kevin A. , Ounpraseuth Songthip , Nembhard Wendy , Magann Everett F. , Lowery Curtis 
Published: June 2017

ObjectivesUltrasound serves an important role in the prenatal diagnosis of fetal structural anomalies. Recently, there has been increased use of teleultrasound protocols. We aimed to evaluate the sensitivity and accuracy of teleultrasound.MethodsWe conducted an Institutional Review Board–approved retrospective cohort study determining the sensitivity and accuracy of teleultrasound. In addition, we evaluated the number of ultrasound examinations required to complete an anatomic survey. Only ultrasound examinations performed for anatomic surveys were included. Studies were excluded if performed before 16 completed weeks' gestation, if they had multiple gestations, or for reasons other than anatomy (eg, Doppler studies and fluid assessment). Prenatal diagnoses were compared with postnatal diagnoses obtained from a robust mandatory birth defects surveillance program that records all birth defects in the entire state, from deliveries before 20 weeks' gestation through infants up to 2 years of age.ResultsA total of 2499 studies were evaluated; 2368 were included. The teleultrasound cohort had a congenital anomaly prevalence of 5.66%. The sensitivity of teleultrasound was 57.46%; the specificity was 98.21%; and the accuracy was 95.9%. Anatomic surveys were completed after 1 visit in 82% of patients, whereas 63% and 61% of the remaining patients required 2 and 3 visits, respectively.ConclusionsTeleultrasound for prenatal diagnosis has similar sensitivity and accuracy as the published literature for on‐site ultrasound. Further studies are needed to compare the sensitivity and accuracy within the same population and further validate this potentially cost‐saving modality.
Nerve ultrasound shows subclinical peripheral nerve involvement in neurofibromatosis type 2
Authors: Telleman Johan A. , Stellingwerff Menno D. , Brekelmans Geert J. , Visser Leo H. 
Published: June 2017

ABSTRACTIntroductionNeurofibromatosis type 2 (NF2) is mainly associated with central nervous system (CNS) tumors. Peripheral nerve involvement is described in symptomatic patients, but evidence of subclinical peripheral nerve involvement is scarce.MethodsWe conducted a cross‐sectional pilot study in 2 asymptomatic and 3 minimally symptomatic patients with NF2 to detect subclinical peripheral nerve involvement. Patients underwent clinical examination, nerve conduction studies (NCS), and high‐resolution ultrasonography (HRUS).ResultsA total of 30 schwannomas were found, divided over 20 nerve segments (33.9% of all investigated nerve segments). All patients had at least 1 schwannoma. Schwannomas were identified with HRUS in 37% of clinically unaffected nerve segments and 50% of nerve segments with normal NCS findings.DiscussionHRUS shows frequent subclinical peripheral nerve involvement in NF2. Clinicians should consider peripheral nerve involvement as a cause of weakness and sensory loss in the extremities in patients with this disease. Muscle Nerve 57: 312–316, 2018
Reliability of sonographic muscle thickness measurements of the thenar and hypothenar muscles
Authors: Misirlioglu Tugce Ozekli , Ozyemisci Taskiran Ozden 
Published: June 2017

ABSTRACTIntroduction This study was undertaken to assess the intra‐ and interrater reliability of sonographic thickness measurements of the thenar and hypothenar muscles. Methods: The thickness of the thenar and hypothenar muscles of both hands of 15 volunteers (7 male, 8 female) were evaluated with a 4–13‐MHz linear probe by 2 examiners who were blinded to each other's measurements. Interrater reliability was then evaluated. To assess intrarater reliability, the first examiner also performed a second measurement after an interval of at least 1 day. Results: Mean age of the subjects was 31.1 ± 9.0 years. Test–retest reliability showed excellent intrarater reliability (intraclass correlation coefficient range: 0.889–0.963) and substantial to excellent results for interrater reliability (intraclass correlation coefficient range: 0.692–0.937). Discussion: We found that ultrasound is a reliable method for thickness measurements of the thenar and hypothenar muscles. Muscle Nerve 57: E14–E17, 2018
RNA structure, binding, and coordination in Arabidopsis
Authors: Foley Shawn W. , Kramer Marianne C. , Gregory Brian D. 
Published: June 2017

From the moment of transcription, up through degradation, each RNA transcript is bound by an ever‐changing cohort of RNA binding proteins. The binding of these proteins is regulated by both the primary RNA sequence, as well as the intramolecular RNA folding, or secondary structure, of the transcript. Thus, RNA secondary structure regulates many post‐transcriptional processes. With the advent of next generation sequencing, several techniques have been developed to generate global landscapes of both RNA–protein interactions and RNA secondary structure. In this review, we describe the current state of the field detailing techniques to globally interrogate RNA secondary structure and/or RNA–protein interaction sites, as well as our current understanding of these features in the transcriptome of the model plant Arabidopsis thaliana. WIREs RNA 2017, 8:e1426. doi: 10.1002/wrna.1426This article is categorized under:

RNA Structure and Dynamics > RNA Structure, Dynamics, and Chemistry
RNA Interactions with Proteins and Other Molecules > Protein–RNA Recognition
Depression and Anxiety Across the First Year After Ischemic Stroke: Findings from a Population-Based New Zealand ARCOS-IV Study
Authors: Barker-Collo Suzanne , Krishnamurthi Rita , Witt Emma , Theadom Alice , Starkey Nicola , Barber P. Alan , Bennett Derrick , Rush Elaine , Arroll Bruce , Feigin Valery 
Published: June 2017

Background: Depression and anxiety are the two most frequently studied emotional outcomes of stroke. However, few previous studies have been carried out at a population level or beyond 6 months post stroke. The aim of this study was to describe depression and anxiety across the first year following incident ischemic stroke (IS), and identify predictive factors in a population-based study.Method: The Hospital Anxiety Depression Scale (HADS) was administered at baseline (within 2 weeks of onset), and again at 1-month, 6-months and 12-months after IS in a sample (N = 365) drawn from a population-based study.Results: Over 75% of those assessed experienced depression or anxiety symptoms below cut-offs for probable disorder across the year post stroke. Moderate to severe symptoms for anxiety were approximately twice as likely (range 4.1%–10.6%) as compared to depression (range 2.5%–5.0%) at each assessment. The greatest improvement in anxiety occurred within the first month post stroke. In contrast, the greatest reduction in depression occurred between 1- to 6-months post stroke.Conclusions: Anxiety symptoms in the moderate to severe range were twice as common as depression, and improved over the first month post stroke, whilst depression symptoms persisted for up to 6 months, indicating a need to target these two issues at different points in the recovery process.
Paleoecology and ice limits of the early Fraser glaciation (Marine Isotope Stage 2) on Haida Gwaii, British Columbia, Canada
Authors: Mathewes Rolf W. , Clague John J. 
Published: June 2017

AbstractOur study combines new geological and paleoecological information to reconstruct the glacial history and terrestrial paleoenvironments on Haida Gwaii during the advance phase of the Fraser glaciation (Marine Isotope Stage 2). At Cape Ball on eastern Graham Island, five accelerator mass spectrometry radiocarbon ages ranging from 23,200±280 to 26,650±390 14C yr BP (ca. 27,000–31,400 cal yr BP) record the earliest approach of mainland glaciers to Haida Gwaii. Abundant marine dinoflagellate cysts indicate isostatic depression by glacial ice in Hecate Strait to the east. At Mary Point on the north coast of Graham Island, similar outwash of a piedmont lobe advancing westward along Dixon Entrance preserves plant remains dated from 19,270±360 to 23,740±300 14C yr BP (22,500–28,600 cal yr BP). These sediments also contain marine indicators. Plant macrofossils, pollen, and invertebrates support the geological evidence of a proglacial environment under a colder-than-present macroclimate. Although some trees were likely present on Graham Island at this time, tundra-like plant communities dominated low-lying areas. A large area that appears to have been ice-free during this time is a portion of the continental shelf off the east coast of Moresby Island, referred to provisionally as the “Hecate Refugium.”
Effects of isoflavone-containing soya protein onex vivocholesterol efflux, vascular function and blood markers of CVD risk in adults with moderately elevated blood pressure: a dose–response randomised controlled trial
Authors: Richter Chesney K. , Skulas-Ray Ann C. , Fleming Jennifer A. , Link Christina J. , Mukherjea Ratna , Krul Elaine S. , Kris-Etherton Penny M. 
Published: June 2017

AbstractEmerging CVD risk factors (e.g. HDL function and central haemodynamics) may account for residual CVD risk experienced by individuals who meet LDL-cholesterol and blood pressure (BP) targets. Recent evidence suggests that these emerging risk factors can be modified by polyphenol-rich interventions such as soya, but additional research is needed. This study was designed to investigate the effects of an isoflavone-containing soya protein isolate (delivering 25 and 50 g/d soya protein) on HDL function (i.e.ex vivocholesterol efflux), macrovascular function and blood markers of CVD risk. Middle-aged adults (n20; mean age=51·6 (sem6·6) years) with moderately elevated brachial BP (mean systolic BP=129 (sem9) mmHg; mean diastolic BP=82·5 (sem8·4) mmHg) consumed 0 (control), 25 and 50 g/d soya protein in a randomised cross-over design. Soya and control powders were consumed for 6 weeks each with a 2-week compliance break between treatment periods. Blood samples and vascular function measures were obtained at baseline and following each supplementation period. Supplementation with 50 g/d soya protein significantly reduced brachial diastolic BP (−2·3 mmHg) compared with 25 g/d soya protein (Tukey-adjustedP=0·03) but not the control. Soya supplementation did not improveex vivocholesterol efflux, macrovascular function or other blood markers of CVD risk compared with the carbohydrate-matched control. Additional research is needed to clarify whether effects on these CVD risk factors depend on the relative health of participants and/or equol producing capacity.
Power and Society in the GDR Reconsidered: Involuntary Psychiatric Commitment, 1949–1963
Authors: Coché Stefanie 
Published: June 2017

AbstractThis article focuses on compulsory psychiatric admissions in the early German Democratic Republic (GDR). Until 1968 there were no East German laws regulating such hospitalizations, a regulatory vaccuum filled by neither the police nor the judicial system. Instead, families made decisions in conjunction with medical personnel about sometimes unlimited stays in psychiatric institutions and clinics—a practice that calls into question popular scholarly characterizations of the relationship between state and society in the GDR. Previous research has explicitly argued that GDR citizens had agency and acted in a so-called eigensinnige manner in many areas, but has not examined this issue with regard to the sensitive practice of forced psychiatric admissions: where there was no state interest, no Eigensinn vis-à-vis authorities was necessary. This was an especially curious constellation given that psychiatric institutions were run by the East German state and that state interventions in this area had been well established under the Third Reich, as well as in the Soviet Union, which served in many areas as a model for the GDR. One might well have expected that continuing state intervention would have thus been path-dependent. This article suggests resurrecting the term Vergesellschaftung (socialization), only shortly discussed in the 1990s, as a way in which to understand the way in which agency on the part of patient families compensated for the absence of formal state regulations regarding such admissions. The term nicely captures such routine forms of compensation by East German society in areas where the state abdicated its responsibility—as was the case in the early GDR when it came to forced psychiatric hospitalizations.
TWO GREAT BANKING CRISES AND THEIR ECONOMIC IMPACT COMPARED: SPAIN 1976/1977 AND 2008
Authors: Betrán Concha , Pons María A. 
Published: June 2017

AbstractThe 1976/1977 crisis was the most severe in Spanish history, but the losses associated with the 2008 crisis are huge. This paper compares these two great banking crises and identifies the main parallels and differences between them. Is the current crisis as severe as that of 1976? What is the impact on the banking and financial sectors? We show that the 1976 crisis is being surpassed by the 2008 crisis in terms of the decline in GDP, industrial production and unemployment, and that these two events have had at least a similar impact in terms of output gap and output loss. Finally, the financial impact measured by different financial indicators confirms the greater severity of the 2008 crisis.
Local rigidity of complex hyperbolic lattices in semisimple Lie groups
Authors: KIM INKANG , ZHANG GENKAI 
Published: June 2017

AbstractWe show the local rigidity of complex hyperbolic lattices in classical Hermitian semisimple Lie groups, SU(p, q), Sp(2n + 2, $\mathbb{R}$), SO*(2n + 2), SO(2n, 2). This reproves or generalises some results in [2, 9, 11, 15].
Does certificate of need law enhance competition in inpatient care market? An empirical analysis
Authors: Paul Jomon A. , Ni Huan , Bagchi Aniruddha 
Published: June 2017

AbstractThis article investigates the impact of Certificate of Need (CON) laws on competition in the inpatient care market. One of the major criticisms of these laws is that it may hinder competition in the health care market, which can lead to higher prices. However, from a theoretical standpoint, CON laws could also promote competition by limiting excessive expansion from incumbents. Our main conclusion is that CON laws by and large enhanced competition in the inpatient market during the period of our study. This indicates that the effects of CON laws to hinder predatory behavior could dominate its effects of preventing new entrants into the inpatient care market. We do not find statistically significant evidence to reject the exogeneity assumption of either CON laws or their stringency in our study. We also find factors such as proportion of population aged 18–44, proportion of Asian American population, obesity rate, political environment, etc., in a state significantly impact competition. Our findings could shed some light to public policy makers when deciding the appropriate health programs or legislative framework to promote health care market competition and thereby facilitate quality health care.
Pay-for-Performance and Interpersonal Deviance
Authors: Gläser Daniel , van Gils Suzanne , Van Quaquebeke Niels 
Published: June 2017

Abstract. Many organizations use pay-for-performance (PfP) programs in order to fuel employee motivation and performance. In the present article, we argue that PfP may also increase employees’ interpersonal deviance (i.e., active harming behavior toward coworkers) because it might induce social comparison and competition. In order to uncover the underlying process, we further argue that this effect should be particularly pronounced for employees who are high in individual competitiveness, that is, employees who have a strong desire for interpersonal comparison and aspire to be better than others. A cross-sectional field study (N = 250) and two experiments (N = 92; N = 192) provide support for our interaction hypothesis. We discuss the theoretical implications regarding PfP and competitiveness, and offer suggestions concerning the practical implementation of PfP.
Necroptosis in neurodegenerative diseases: a potential therapeutic target
Authors: Zhang Shuo , Tang Mi-bo , Luo Hai-yang , Shi Chang-he , Xu Yu-ming 
Published: June 2017

AbstractNeurodegenerative diseases are a group of chronic progressive disorders characterized by neuronal loss. Necroptosis, a recently discovered form of programmed cell death, is a cell death mechanism that has necrosis-like morphological characteristics. Necroptosis activation relies on the receptor-interacting protein (RIP) homology interaction motif (RHIM). A variety of RHIM-containing proteins transduce necroptotic signals from the cell trigger to the cell death mediators RIP3 and mixed lineage kinase domain-like protein (MLKL). RIP1 plays a particularly important and complex role in necroptotic cell death regulation ranging from cell death activation to inhibition, and these functions are often cell type and context dependent. Increasing evidence suggests that necroptosis plays an important role in the pathogenesis of neurodegenerative diseases. Moreover, small molecules such as necrostatin-1 are thought inhibit necroptotic signaling pathway. Understanding the precise mechanisms underlying necroptosis and its interactions with other cell death pathways in neurodegenerative diseases could provide significant therapeutic insights. The present review is aimed at summarizing the molecular mechanisms of necroptosis and highlighting the emerging evidence on necroptosis as a major driver of neuron cell death in neurodegenerative diseases.