bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Cognitive-Behavioral Therapy and Spiritual-Religious Intervention on Improving Coping Responses and Quality of Life Among Women Surviving from Breast Cancer
Authors: Ghahari Shahrbanoo , Fallah Rahele , Bolhari Jafar , Mousavi Mahdi , Akbari Mohammad Esmaeel 
Published: June 2017

Objective.The present study aims to evaluate the effectiveness of cognitive behavioral therapy (CBT) and spiritual-religious intervention in improvement coping responses and quality of life among women surviving from breast cancer.Methods.This was a semi-experimental study. Forty-five breast cancer survivor referred to cancer research center at Shahid Beheshti university of medical Sciences in Tehran, assigned in 3 groups randomly (CBT group, spiritual-religious group and control group). The interventions were eight sessions cognitive-behavioral therapy and spiritual-religious intervention. The participants were evaluated through quality of life questionnaire published by european organization for research and treatment of cancer (QLQ-30C-ver3) and coping responses inventory (CRI). The data were analyzed using covariance.Finding.Although both intervention groups improved in coping and quality of life, it was not statistically significant(P < 0.08).Conclusion.Although both intervention groups improved in coping and quality of life but there is no differences between two groups.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Basic Principles of Supervision and Its Ethics in Cognitive Behavioral Therapy
Authors: Vyskocilova J. , Prasko J. , Slepecky M. , Kotianova A. 
Published: June 2017

BackgroundSupervision is the systematic guidance of a therapist by a supervisor. It is a basic part of training and ongoing education in cognitive behavioral therapy (CBT). Self-reflection and ethical reflection are an important part of supervision.MethodThe Pubmed database was searched for articles using the keywords supervision in CBT, therapeutic relations, ethics, transference, counter transference, schema therapy, dialectical behavioral therapy, acceptance and commitment therapy.ResultsWe discuss conceptual aspects related to supervision and the role of self-reflection and ethical reflection. The task of supervision is to increase the value of the therapeutic process in the client's best interest. Establishing the supervisor-supervisee relationship is based on principles similar to those in the therapeutic relationship. Additionally, supervision is oriented towards increasing the therapist's competencies. The CBT therapist's core competencies involve good theoretical knowledge, professional behavior towards clients, ability to use specific therapeutic strategies for maintaining the therapeutic relationship, sensitivity to parallel processes and accomplishment of changes, and adherence to ethical norms. Given the fact that during supervision, the supervisee may be at any stage of his/her training, supervision must take into consideration where the therapist is in his/her training and development and what he/she has or has not learnt.ConclusionsBoth the literature and our experience underscore the importance of careful supervision of cognitive behavioral therapy. Numerous approaches are used in supervision, which is associated with the abilities to self-reflect and to realize transference and counter transference mechanisms.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Perinatal Stress, Anxiety, and Depression: Effects of a MBCP Intervention on Mother-infant Interaction
Authors: Setterberg S.E. , Nissen E. , Jonas W. , Niemi M. 
Published: June 2017

IntroductionTransition into parenthood is a demanding phase in life and exposes the becoming parents to vulnerability for depression, anxiety and stress. Perinatal mental health problems are a major public health issue and many women suffering from depression during their first year after delivery. High levels of stress during pregnancy are associated with adverse psychological and physiological outcomes for the infant and parents. There seems to be an intergenerational transmission of mental health from parent to infant. The current study evaluated the effectiveness of mindfulness intervention during pregnancy in reducing depression symptoms, anxiety and perceived stress in parents-to-be.ObjectivesAssess whether the mindfulness will improve interaction between mother-infant at 12 months.MethodsPerceived stress scale and Edinburgh postnatal depression scale used to measure stress and depression during pregnancy. Parent child early relational assessment assessed mother-infant interaction.ResultsInhibited parent-infant relationships were more common in the control group comparing to the mindfulness intervention group. This is in line with previous research on periantal depression, anxiety, and stress, showing more dysfunctional dyads. A depressed mother has reduced capability to be alert to her baby's signals, which is necessary for appropriate parent-infant relationship to occur. The cumulative effect of impaired parent-infant relationship is a “depressed dyad” of mother and infant.ConclusionMindfulness intervention reduced depressive symptoms, anxiety, and perceived stress in pregnant women. At 12 months mother-infant relationship assessment, the mindfulness intervention group dyads showed a more attuned mother-infant interaction.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Quality of Life of Children and Youngsters who Attended the Psycho-Educational Program “+ Familia” (+family)
Authors: Lima C. , Cunha G. , Brandão F. 
Published: June 2017

The program “+ Família” part of the activities promoted by CLDS + from Paredes de Coura in 2015, has enabled to act at the level of strategy development for qualifying families. The perceived quality of life of children and youngsters was evaluated in 2 moments: at the beginning (n = 23) and in the end (n = 11). We used the scale kidscreen-10, translated and measured for the Portuguese population. At the first moment, the sample consisted of 65% of women and 35% man; 87% aged between 6 and 10 years old and 13% aged between 11 and 15 years old; 74% attended the 1st cycle of studies and 13% had some type of disability. Based on 4 of the questions, the perception of quality of life has improved, between the beginning and the end of the program implementation. So for the remaining 6 questions, quality of life was perceived in a more negative way in the same period. An intra subject analysis would have to be made in order to measure the results’ bias due to the absence of 12 subjects in the final evaluation.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Confirmatory Factor Analysis of the Frost et al Multidimensional Perfectionism Scale-24 (F-MPS 24)
Authors: Soares M.J. , Azevedo J. , Pereira A.T. , Araújo A.I. , Castro J. , Chaves B. , Roque C. , Bajouco M. , Macedo A. 
Published: June 2017

IntroductionThe F-Multidimensional Perfectionism Scale is a widely used instrument to assess perfectionism trait. The original scale comprises 35-items that measure the six dimensions of Frost et al (1990) conceptualization of perfectionism: personal standards (PS), concern over mistakes (CM), doubts about actions (DA), parental criticism (PC), Parental expectations (PE) and Organization (O).ObjectiveTo examine the factor structure of the 24-items short form of the F-MPS using confirmatory factor analysis (CFA), in a sample of Portuguese university students.MethodsThe sample comprises 344 university students (68.4% females), with an average age of 20.69 years (SD = 1.59; range = 17–24). They completed a version of F-MPS with 24 items that results from the selection of the four items with highest loadings in the respective six dimensions of the original Portuguese version (Amaral et al., 2013).ResultsAfter correlated errors, we obtained a good fit for the FMPS with six factors (X2/df = 2.125; CFI = .936; GFI = .891, RMSEA = .057; P[rmsea≤ .05] = .043). The 24-item F-MPS short form revealed good internal consistency (α = .825). The six dimensions showed acceptable or good internal consistency, as revealed by Cronbach's alpha (α: PS = .80; CM = .76; DA = .82; PC = .84; PE = .89, O = .85).ConclusionsThe F-MPS 24 items short form CFA confirmed the six factor model as a reliable and valid measure to assess multidimensional perfectionism in Portuguese university students.Disclosure of interestThe authors have not supplied their declaration of competing interest.
“Neurodevelopment in a dish” Elucidates the Mechanisms of Autism Spectrum Disorder
Authors: Ilieva M. , Kamand M. , Kolev K. , Forsberg S.L. , Svenningsen Å.F. , Sheldrick-Michel T. 
Published: June 2017

IntroductionAutism spectrum disorders (ASD) is a group of neurodevelopmental disorders characterized by deficits in social cognition, communication, and behavioral flexibility. Most of the cases appear to be caused by the combination of autism risk genes and environmental factors affecting early embryonal brain development. The current animal and 2D cellular models are not able to recapitulate the complex integrity of the developing brain. Therefore a model of the brain that can cast a light on the pathological processes during brain development is of a high need.Aim and objectivesThe aim of our research is to develop a three-dimensional brain organotypic system (brain organoids) for culturing patient's derived induced pluripotent stem cells (iPSC).MethodologyWe propose a multidisciplinary approach, involving the generation of patient specific iPSC from somatic cells (fibroblasts) and 3D culturing techniques to build a complex “humanized” in vitro platform for ASD research. Further we will investigate differences in gene expression of potential disease related markers and cellular phenotype between autistic patients and controls.ResultsBrain organoids have the ability to recreate the right complexity of the brain. On the cellular and gene expression level, organoids demonstrate a high similarity to the neurodevelopment in vivo and can therefore recapitulate early stages of the neurogenesis.ConclusionTo date organoids are the most relevant cellular in vitro platform for the understanding the mechanisms behind ADS pathology. Organoids are a good modeling system for elucidating the role of epigenetic and environmental factors for development of ASD.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Confirmatory Factor Analysis of a Portuguese Short Version of the Cognitive Emotional Regulation Scale
Authors: Martins M.J. , Pereira A.T. , Soares M.J. , Amaral A.P. , Madeira N. , Araújo A. , Macedo A. 
Published: June 2017

IntroductionThe cognitive emotions regulation questionnaire (CERQ) is a 36-item questionnaire to measures specific cognitive emotion regulation strategies used in response to the experience of threatening or stressful life events. The Portuguese version of CERQ proved to be a reliable and valid measure to evaluate eight dimensions: Positive reappraisal and planning, positive refocusing, rumination, blaming others, putting into perspective and self-blame.ObjectiveTo confirm the dimensional structure of a Portuguese short version of the CERQ using Confirmatory Factor Analysis (CFA).MethodItems selection was based on the previous results of the exploratory factor analysis of the 36-items version. Items presenting the highest loading (≥ 70) in their respective factor were selected. A preliminary short version composed of 22 items were answered by a sample of 480 university students (81.9% females), with a mean age of 19.49 years (SD = 2.047; range = 17–30). CFA (using Mplus software) was used to test if the eight dimensions’ model suggested by prior exploratory factor analyses fitted the data.ResultsThe eight dimensions’ model has a good fit (χ2 = 424.015, P < .01; RMSEA = 0.056, 90%CI = 0.049–0.063; CFI = 0.930; TLI = 0.910; SRMR = 0.051). Although composed of fewer numbers of items, all subscales presented good reliability (Cronbach alpha< 70).ConclusionsThe CERQ-22 is a reliable and valid measure to evaluate cognitive emotion regulation strategies in young adults. Being a shorter version it is particularly useful for multivariate and prospective studies. In the near future we will test this structure in a clinical sample.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Mild Depressive Symptoms Mediate the Impact of Childhood Trauma on Long-Term Functional Outcome in Early Psychosis Patients
Authors: Alameda L. , Philippe G. , Philipp B. , Q. D. Kim , Philippe C. 
Published: June 2017

IntroductionThe mechanism linking childhood trauma (CT) to the functional deficits observed in early psychosis (EP) patients is as yet unknown.ObjectivesTo examine the potential mediating effect of depressive symptoms in this well-established association.MethodsTwo hundred nine EP subjects aged 18-35 were assessed for functioning and psychopathology after 2, 6, 12, 18, 24, 30, and 36 months of treatment. Patients were classified into early-trauma if they had faced at least one experience of abuse (physical, sexual, or emotional) or neglect (physical or emotional) before age 12, and late-trauma if the exposure had occurred between ages 12 and 16. Psychopathology was assessed with the Positive and Negative Syndrome Scale and the Montgomery-Asberg Depression Rating Scale. Functioning was measured with the Global Assessment of Functioning (GAF) and the Social and Occupational Functioning Assessment Scale (SOFAS). Mediation analyses were performed in order to study whether the relationship between CT and functioning was mediated by depressive symptoms.ResultsWhen compared with nonexposed patients, early but not late trauma patients showed lower levels of GAF and SOFAS scores over all the time points, excepting after the first assessment. After 30 and 36 months, the effect of early trauma on functioning was completely mediated by depressive symptoms. No mediating effect of positive or negative symptoms was highlighted at those time points.ConclusionMild depressive symptoms mediated the impact of early trauma on long-term functional outcome. Intensifying pharmacologic and/or psychotherapeutic treatment, focused on the depressive dimension, may help traumatized EP patients to improve their functioning.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Systemic Review: High Dose Olanzapine Treatment for Treatment Resistant Schizophrenia
Authors: Azvee Z. , Lally J. 
Published: June 2017

ObjectivesSchizophrenia is a major mental illness with a progressive course. Thirty percent of cases of patients with schizophrenia do not respond to adequate trials of at least 2 different groups of antipsychotics,are currently classified as having treatment resistant schizophrenia (TRS). Clozapine remains the gold standard, treatment of choice for TRS. However, clozapine does not come without its own challenges. Its risk profile, particularly agranulocytosis, reported in 1% of cases, has led to the necessity of weekly blood counts within the first 18 weeks of treatment and subsequently every month with slow dose titration. Clinically, sedation, weight gain and hypersalivation may further hamper the compliance of patients. Non-compliance has been reported to cause rebound psychosis. Recent studies have raised questions as to which antipsychotic is most efficacious for TRS. Thus, we conducted a systematic review of high dose olanzapine treatment for people with TRS.MethodA systematic review of prospective studies found through search of PubMed, Scopus and hand-searched key papers which included randomized controlled trials and open-label studies which looked at high dose of olanzapine treatment response for TRS.ResultsThe study is currently ongoing and preliminary results will be presented at the conference in April 2017.ConclusionsThe gravity of burden TRS brings to patients extends itself to their families, carers and clinicians. Further evidence on which antipsychotic is more efficacious for patients with TRS would have huge implications in terms of health benefits for the patients, better informed clinical decisions and also health economics in general.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Characteristics and duration of untreated illness in correlation with insight level of first time diagnosed schizophrenia patients in rural region of Latvia
Authors: Berze L. , Pavlovs K. , Slikova K. , Bodins V. , Samule I. , Kurakina N. , Smonins I. , Rancans E. 
Published: June 2017

IntroductionImproved insight level among schizophrenia patients is predictive for better illness prognosis.ObjectiveExplore factors connected to insight.AimEvaluate the insight level and clinical characteristics of first time hospitalized schizophrenia spectrum patients.MethodsAll consecutive first time hospitalized schizophrenia spectrum patients in a psychiatric hospital from 01.01.2016–26.09.2016. Patients were interviewed upon hospitalization and at the discharge with Scale for the assessment of positive symptoms (SAPS) and negative symptoms (SANS), Schedule of assessment of insight-extended (SAI-E), The Calgary depression scale for schizophrenia (C-sch), sociodemographic and clinical data were collected. All participants signed written informed consent and the study was approved by the Riga Stradins University Ethics committee.ResultsFrom 45 first episode patients, 38 met the inclusion criteria. Mean age was 37.66 years (SD: 11.48 years), the average duration of untreated illness (DUI) was 40.5 months (SD: 57.35 months). Psychopathologic symptoms and insight levels evaluated in scores in the 1st and 2nd interviews were as follows: SAPS 69.11 (SD: 20.78) and 33.61 (SD: 18.04), SANS 63.21 (SD: 25.30) and 40.95 (SD: 24.47), SAI-E 15.50 and 27.24 (SD: 13.24), P < 0.001, C-sch 8.50 (SD: 5.31) and 4.27 (SD: 2.86), P < 0.05. There was no statistically significant correlation between DUI and insight level. A higher level of insight at hospitalization correlated with higher levels of depression: r = 0.569, P < 0.001.ConclusionsWe noticed a tendency that lower insight levels might correlate with longer periods of untreated illness. We found that higher insight levels correlated with higher symptoms of depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.
A novel methodology to evaluate the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology
Authors: Cox D. , Gottschalk M. , Wesseling H. , Ernst A. , Cooper J. , Bahn S. 
Published: June 2017

Rodent models of schizophrenia (SCZ) are indispensable when screening for novel treatments, but quantifying their translational relevance with the underlying human pathophysiology has proved difficult. A novel systems methodology (shown in Figure 1) was developed integrating and comparing proteomic data of anterior prefrontal cortex tissue from SCZ post-mortem brains and matched controls with data obtained from four established glutamatergic rodent models, with the aim of evaluating which of these models represent SCZ most closely. Liquid chromatography coupled tandem mass spectrometry (LC-MSE) proteomic profiling was applied comparing healthy and “disease state” in human post-mortem samples and rodent brain tissue samples. Protein-protein interaction networks were constructed from significant abundance changes and enrichment analyses enabled the identification of pathophysiological characteristics of the disorder, which were represented across all four rodent models. Subsequently, these functional domains were used for cross-species comparisons. Five functional domains such as “development and differentiation” represented across all four rodent models, were identified. It was quantified that the chronic phencyclidine (cPCP) model represented SCZ brain changes most closely for four of these functional domains, by using machine-learning techniques. This is the first study aiming to quantify which rodent model recapitulates the neuropathological features of SCZ most closely. The methodology and findings presented here support recent efforts to overcome translational hurdles of preclinical psychiatric research by associating behavioural endophenotypes with distinct biological processes.Disclosure of interestThe authors have not supplied their declaration of competing interest.
A systematic review of the pharmacological treatment of delusional disorder
Authors: Negro J.E. Muñoz , Cervilla J. 
Published: June 2017

IntroductionPharmacological treatment is the gold standard in delusional disorder (DD), moreover the second generation antipsychotics (SGA) are widely used in the treatment of DD, in spite of this, none SGA is authorized for the treatment of DD.ObjectivesTo evaluate the evidence available for pharmacological treatment in adults with DD. Especially, that concerning SGA.MethodsA systematic review on pharmacological treatment of DD was conducted. We selected the best evidence available. Then, we analysed them critically, assessing its biases and quality, finally performed a narrative and quantitative synthesis.ResultsThe quality of the evidence was very low. There were not randomized clinical trials. n = 385, 177 SGA. Antipsychotics achieved a good response in a 33.6% of the patients. First generation antipsychotics (FGA) did show superiority compared to SGA (39% good response vs. 28%, respectively. P ≤ 0.02). We could not find data about superiority of any drug over other. Pimozide, traditionally considered the most effective drug, did not confirm to be a superior treatment compared to others. Reasons for superiority of FGA were analyzed. The role of another treatments were testimonial, but antidepressants can be a promising treatment.ConclusionsThere is no evidence to make strong recommendations, although antipsychotics in general appear to be an effective treatment for DD. Superiority of FGA against SGA was shown. We need to develop clinical trials in DD and SGA, since their better tolerance profile might be the best candidates to do.Disclosure of interestThe authors have not supplied their declaration of competing interest.
A scale of autonomy for patients with schizophrenia – new instrument for clinical assessment of the level of independency: Description and validation
Authors: Rupchev G. , Morozova M. 
Published: June 2017

IntroductionToday the scales for measurement of functional status and life satisfaction (GAF, PSP, EQ-5D, SQLS) gain more importance in assessing schizophrenic patients. Autonomy of living is to the great extent the basis of patient well-being. Each of these scales has the criteria, testing ability for independent life, but none of it tests autonomy as a separate object.ObjectiveDevelopment of a new scale.AimsDescription and validation of a scale for evaluation of autonomy of living in schizophrenic patients.MethodsForty patients diagnosed with schizophrenia according to ICD−10 (F 20.хх), 13 males and 27 females, aged 49.8 ± 9, disease duration is 22 ± 8.6 years. New scale and PANSS, CGI-S, NSA, BACS, GAF, PSP was administered.ResultsThe scale comprises five points (activity, intentional behavior, range of social interaction, specificity of interaction with the doctor (medical conventionality) and autonomy), and total score. The internal consistency of the scale was high – cronbach's alpha 0.83. The construct validity with GAF and PSP was moderate (R varied from 0.36 to 0.55). The total score of the new scale correlated with the PANSS negative subscale score (R = −0.51), with CGI-S score (R = −0.57), and with the BACS total score (R = −0.57).ConclusionThe scale of autonomy corresponds to the major psycho-diagnostic requirements: internal consistency, construct and discriminative validities. It can be considered a new instrument for assessing the integrative target of treatment and rehabilitation of patients with schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.