bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient, Provider, and Practice Characteristics Associated with Inappropriate Antimicrobial Prescribing in Ambulatory Practices
Authors: Schmidt Monica L. , Spencer Melanie D. , Davidson Lisa E. 
Published: January 2018

OBJECTIVETo reduce inappropriate antimicrobial prescribing across ambulatory care, understanding the patient-, provider-, and practice-level characteristics associated with antibiotic prescribing is essential. In this study, we aimed to elucidate factors associated with inappropriate antimicrobial prescribing across urgent care, family medicine, and pediatric and internal medicine ambulatory practices.DESIGN, SETTING, AND PARTICIPANTSData for this retrospective cohort study were collected from outpatient visits for common upper respiratory conditions that should not require antibiotics. The cohort included 448,990 visits between January 2014 and May 2016. Carolinas HealthCare System urgent care, family medicine, internal medicine and pediatric practices were included across 898 providers and 246 practices.METHODSPrescribing rates were reported per 1,000 visits. Indications were defined using theInternational Classification of Disease, Ninth and Tenth Revisions, Clinical Modification(ICD-9/10-CM) criteria. In multivariable models, the risk of receiving an antibiotic prescription was reported with adjustment for practice, provider, and patient characteristics.RESULTSThe overall prescribing rate in the study cohort was 407 per 1,000 visits (95% confidence interval [CI], 405–408). After adjustment, adult patients seen by an advanced practice practitioner were 15% more likely to receive an antimicrobial than those seen by a physician provider (incident risk ratio [IRR], 1.15; 95% CI, 1.03–1.29). In the pediatric sample, older providers were 4 times more likely to prescribe an antimicrobial than providers aged ≤30 years (IRR, 4.21; 95% CI, 2.96–5.97).CONCLUSIONSOur results suggest that patient, practice, and provider characteristics are associated with inappropriate antimicrobial prescribing. Future research should target antibiotic stewardship programs to specific patient and provider populations to reduce inappropriate prescribing compared to a “one size fits all” approach.Infect Control Hosp Epidemiol2018;39:307–315
Systematic Review of Clinician-Reported Barriers to Provision of Smoking Cessation Interventions in Hospital Inpatient Settings
Authors: Sharpe Tom , Alsahlanee Ali , Ward Ken D. , Doyle Frank 
Published: January 2018

Background: Although the hospital inpatient setting arguably provides an ideal opportunity to engage patients in smoking cessation interventions, this is done infrequently. We therefore aimed to systematically review the perceived barriers to the implementation of smoking cessation interventions in the hospital inpatient setting.Methods: A systematic literature search was conducted specific to hospital-based healthcare workers’ perceived barriers to implementing smoking cessation interventions. Reported barriers were categorised using the capability, opportunity and motivation (COM-B) framework.Results: Eighteen studies were selected for inclusion, which consisted of cross-sectional surveys and interviews. The most commonly identified barrier in capability was lack of knowledge (56% of studies); in Opportunity, it was a lack of time (78%); while in Motivation, a lack of perceived patient motivation to quit smoking (44%). Seventeen other barriers were also endorsed, but less frequently.Conclusion: Healthcare workers report a plethora of barriers to providing smoking cessation interventions in hospital settings, which cover all aspects of the COM-B framework. These impediments need to be addressed in a multidisciplinary approach, at clinical, educational, and administrative levels, to improve intervention provision.
Wanting, and Weighting: White Women and Descriptive Representation in the 2016 Presidential Election
Authors: Phillips Christian 
Published: January 2018

AbstractThis paper demonstrates that the relationship between wanting a descriptive representative based on gender, and giving that attitude weight in voting decisions, is weakest among White women voters. Among under-represented groups of voters, White women were uniquely positioned going into the 2016 presidential election—they had the option to choose “one of their own” in terms of race and gender. Yet, the majority did not vote for the White woman on the ballot, Hillary Rodham Clinton. This outcome is an opportunity to interrogate how descriptive representation functions in different ways across groups with distinct socio-political positions in American politics. I argue that the relationship between desiring descriptive representation, and giving it weight when deciding for whom to vote for, is different across groups. Using American National Election Survey (ANES) data, I show that this is the case in the 2016 election. Nearly two-thirds of White women who said that electing more women is important, voted for Trump. Moreover, White women's espoused belief in the necessity of electing more women had no significant effect on their ultimate vote choice. In contrast, the same desire for increased descriptive representation based on gender had large, positive, and significant effects on women of color's vote choice. This study bears on extant research considering descriptive representation's importance to voters based only on race, or gender, and on the broader literature linking group identities and voter behavior.
HEAD RICE YIELD OF CROPS HARVESTED BY COMBINE AND HAND AT DIFFERENT RIPENING TIMES IN CAMBODIA
Authors: BUNNA SOM , SEREYVUTH HOURN , SOMALY YIM , NGOY NGON , MENGSRY LOAN , CHEA SARETH , OUK MAKARA , MITCHELL JAQUIE , FUKAI SHU 
Published: January 2018

SUMMARYExperiments were conducted across 2 years to determine the effect of harvesting methods – combine harvester and hand harvesting – and harvest time during ripening on milling quality of long grain rice grown in the rainfed lowland ecosystem in Cambodia. Head rice yield (HRY) was highest when rice was harvested 25 days after flowering and decreased with delay in harvesting at 35 and 45 days after flowering. This was accompanied by a general decline in grain moisture content at harvest, although it was still high at 24–25% at 35 days after flowering. The decline in HRY was associated with increases in fissured grain percentage observed immediately after harvest. Hand harvesting produced 2–6% higher HRY than combine harvesting. Fissured grain in hand harvested crops was lower in year 1, but was similar to combine harvested crops in year 2. Both hand and combine harvested crops were sun-dried but rough rice harvested by combine was dried on plastic sheet and this may have contributed to reduction in HRY. Maximum HRY percentage was only about 44% and the factors contributing to this low HRY were discussed. Harvesting time and methods had no significant effect on grain yield, but the field grain loss during the harvesting operation was 2–5% higher in combine than hand harvesting.
ASSOCIATION BETWEEN HIV AWARENESS FACTORS, HEALTH FACILITY CHARACTERISTICS AND RISKY SEXUAL BEHAVIOUR AMONG YOUNG WOMEN IN ZOMBA DISTRICT, MALAWI
Authors: Ward-Peterson Melissa , Fennie Kristopher , Baird Sarah , Coxe Stefany , Trepka Mary Jo , Madhivanan Purnima 
Published: January 2018

SummaryThe objective of this study was to examine the association between multilevel factors related to HIV awareness and risky sexual behaviour among young women in Zomba district, Malawi. Secondary analyses of the Schooling, Income, and Health Risk (SIHR) study were undertaken. Four outcomes related to risky sexual behaviour were examined among young women: if participants had ever had sex, consistent condom use and two scores measuring risk related to partner history and age during sexual activity. Independent variables included individual-level factors such as education and rural/urban residence, as well as higher-level factors such as household’s highest level of education and health facility characteristics. Regression models with cluster-robust standard errors and multilevel regression models were used to estimate associations; analyses were stratified into two strata by school enrolment status, i.e. whether the women were in school (N=1407) or had dropped out of school (N=407) at baseline of the SIHR study. For both strata, increasing age and residing within 16 km of an urban centre (‘near rural’ residence) increased the odds of ever having sex; lower educational achievement was associated with lower age during sexual activity. A history of pregnancy was associated with lower odds of condom use and riskier partner history. For women in school at baseline, lower household education was associated with higher odds of ever having sex (OR=1.48; 95% CI: 1.06, 2.07); near-rural and far-rural (≤16 km and >16km from urban centre, respectively) residence were associated with decreased odds of condom use (OR=0.47; 95% CI: 0.28, 0.78; and OR=0.27; 95% CI: 0.11, 0.65, respectively). For those not in school at baseline, lower household education was associated with lower age during sexual activity (β=0.31, 95% CI: 0.05, 0.58). Also for women not in school, the use of private or non-governmental health facilities was associated with decreased odds of condom use (OR=0.51, 95% CI: 0.39, 0.67) and higher age during sexual activity (β=−0.30, 95% CI: −0.52, −0.09). While individual factors were associated with risky sexual behaviour in both strata, contextual factors differed.
Omega–Phi compensated GID in side inclination mode for measurement of residual stress in polycrystalline thin films
Authors: Wang Xiaodong , van Riessen Arie 
Published: January 2018

The grazing incidence diffraction (GID) method in side inclination mode, described by Ma et al. in 2002, of polycrystalline thin-film residual stress was revisited and explained using simple geometric relations. To overcome the issue of decreasing peak intensity of this method, which is induced by the decreasing incident angle because of the Eulerian cradle Chi-tilt, an improvement of Omega (ω)–Phi (φ) compensation was devised and applied to a NiFe thin-film sample. The geometry of this improved ω–φ compensated GID method in side inclination mode is detailed in this paper. This improvement guarantees a constant incident angle on the sample surface and a fixed sample illumination volume during measurement. The measured data were analysed using parametric refinement in DIFFRAC.TOPAS v6 software in Launch Mode, and details of the input file (.INP) are explained in this paper. The tensile stress of the NiFe thin-film sample was measured to be 1181 ± 85 MPa using this improved method.
The Chicken and Egg Question: Satisfaction with Democracy and Voter Turnout
Authors: Kostelka Filip , Blais André 
Published: January 2018

ABSTRACTPolitical scientists, analysts and journalists alike have long believed that the degree of satisfaction with the functioning of democracy determines voter turnout. We use survey data from 24 panel studies to demonstrate that this causal relationship is actually reversed: voter turnout affects satisfaction with democracy. We also show that this reversed relationship is conditioned by election type, electoral system, and election outcomes. These findings are important because: (1) They question conventional wisdom and a large body of scientific literature; (2) They invite a more nuanced approach towards the study of the relationship between evaluations of regime performance and political participation; and (3) They emphasize the vital role of elections in shaping citizens’ perception of the democratic process.
The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms
Authors: Grohme Markus Alexander , Schloissnig Siegfried , Rozanski Andrei , Pippel Martin , Young George Robert , Winkler Sylke , Brandl Holger , Henry Ian , Dahl Andreas , Powell Sean , Hiller Michael , Myers Eugene , Rink Jochen Christian 
Published: January 2018

Abstract
The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.
mTOR signaling in skeletal development and disease
Authors: Chen Jianquan , Long Fanxin 
Published: January 2018

AbstractThe mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that integrates inputs from nutrients and growth factors to control many fundamental cellular processes through two distinct protein complexes mTORC1 and mTORC2. Recent mouse genetic studies have established that mTOR pathways play important roles in regulating multiple aspects of skeletal development and homeostasis. In addition, mTORC1 has emerged as a common effector mediating the bone anabolic effect of Igf1, Wnt and Bmp. Dysregulation of mTORC1 could contribute to various skeletal diseases including osteoarthritis and osteoporosis. Here we review the current understanding of mTOR signaling in skeletal development and bone homeostasis, as well as in the maintenance of articular cartilage. We speculate that targeting mTOR signaling may be a valuable approach for treating skeletal diseases.
Ubiquitin C decrement plays a pivotal role in replicative senescence of bone marrow mesenchymal stromal cells
Authors: Kim Jiyeon , Kim Yonggoo , Choi Hayoung , Kwon Ahlm , Jekarl Dong Wook , Lee Seungok , Jang Woori , Chae Hyojin , Kim Jung Rok , Kim Jung Min , Kim Myungshin 
Published: January 2018

AbstractHuman bone marrow-mesenchymal stromal cells (hBM-MSCs) undergo cellular senescence during in vitro culture. In this study, we defined this replicative senescence as impaired proliferation, deterioration in representative cell characteristics, accumulated DNA damage, and decreased telomere length and telomerase activity with or without genomic abnormalities. The UBC gene expression gradually decreased during passaging along with the reduction in series of molecules including hub genes; CDK1, CCNA2, MCM10, E2F1, BRCA1, HIST1H1A and HIST1H3B. UBC knockdown in hBM-MSCs induced impaired proliferation in dose-dependent manner and showed replicative senescence-like phenomenon. Gene expression changes after UBC knockdown were similar to late passage hBM-MSCs. Additionally, UBC overexpession improved the proliferation activity of hBM-MSCs accompanied by increased expression of the hub genes. Consequently, UBC worked in higher-order through regulation of the hub genes controlling cell cycle and proliferation. These results indicate that the decrement of UBC expression plays a pivotal role in replicative senescence of hBM-MSCs.
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
Authors: Kim Do-Hyun , Park Hong-Jai , Lim Sangho , Koo Ja-Hyun , Lee Hong-Gyun , Choi Jin Ouk , Oh Ji Hoon , Ha Sang-Jun , Kang Min-Jong , Lee Chang-Min , Lee Chun Geun , Elias Jack A. , Choi Je-Min 
Published: January 2018

AbstractChitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknown. Here we show that Chi3l1 expression was increased in activated T cells, especially in Th2 cells. In addition, Chi3l1-deficient T cells are hyper-responsive to TcR stimulation and are prone to differentiating into Th1 cells. Chi3l1-deficient Th1 cells show increased expression of anti-tumor immunity genes and decreased Th1 negative regulators. Deletion of Chi3l1 in T cells in mice show reduced melanoma lung metastasis with increased IFNγ and TNFα-producing T cells in the lung. Furthermore, silencing of Chi3l1 expression in the lung using peptide-siRNA complex (dNP2-siChi3l1) efficiently inhibit lung metastasis with enhanced Th1 and CTL responses. Collectively, this study demonstrates Chi3l1 is a regulator of Th1 and CTL which could be a therapeutic target to enhance anti-tumor immunity.
BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
Authors: Zhu Sen , Zhao Dongyu , Yan Lin , Jiang Weihua , Kim Jung-Sun , Gu Bingnan , Liu Qipeng , Wang Rui , Xia Bo , Zhao Jonathan C. , Song Gang , Mi Wenyi , Wang Rong-Fu , Shi Xiaobing , Lam Hung-Ming , Dong Xuesen , Yu Jindan , Chen Kaifu , Cao Qi 
Published: January 2018

Abstract
BMI1, a polycomb group (PcG) protein, plays a critical role in epigenetic regulation of cell differentiation and proliferation, and cancer stem cell self-renewal. BMI1 is upregulated in multiple types of cancer, including prostate cancer. As a key component of polycomb repressive complex 1 (PRC1), BMI1 exerts its oncogenic functions by enhancing the enzymatic activities of RING1B to ubiquitinate histone H2A at lysine 119 and repress gene transcription. Here, we report a PRC1-independent role of BMI1 that is critical for castration-resistant prostate cancer (CRPC) progression. BMI1 binds the androgen receptor (AR) and prevents MDM2-mediated AR protein degradation, resulting in sustained AR signaling in prostate cancer cells. More importantly, we demonstrate that targeting BMI1 effectively inhibits tumor growth of xenografts that have developed resistance to surgical castration and enzalutamide treatment. These results suggest that blocking BMI1 alone or in combination with anti-AR therapy can be more efficient to suppress prostate tumor growth.
Steric exclusion and protein conformation determine the localization of plasma membrane transporters
Authors: Bianchi Frans , Syga Łukasz , Moiset Gemma , Spakman Dian , Schavemaker Paul E. , Punter Christiaan M. , Seinen Anne-Bart , van Oijen Antoine M. , Robinson Andrew , Poolman Bert 
Published: January 2018

AbstractThe plasma membrane (PM) of Saccharomyces cerevisiae contains membrane compartments, MCC/eisosomes and MCPs, named after the protein residents Can1 and Pma1, respectively. Using high-resolution fluorescence microscopy techniques we show that Can1 and the homologous transporter Lyp1 are able to diffuse into the MCC/eisosomes, where a limited number of proteins are conditionally trapped at the (outer) edge of the compartment. Upon addition of substrate, the immobilized proteins diffuse away from the MCC/eisosomes, presumably after taking a different conformation in the substrate-bound state. Our data indicate that the mobile fraction of all integral plasma membrane proteins tested shows extremely slow Brownian diffusion through most of the PM. We also show that proteins with large cytoplasmic domains, such as Pma1 and synthetic chimera of Can1 and Lyp1, are excluded from the MCC/eisosomes. We hypothesize that the distinct localization patterns found for these integral membrane proteins in S. cerevisiae arises from a combination of slow lateral diffusion, steric exclusion, and conditional trapping in membrane compartments.
Amorphous martensite in β-Ti alloys
Authors: Zhang Long , Zhang Haifeng , Ren Xiaobing , Eckert Jürgen , Wang Yandong , Zhu Zhengwang , Gemming Thomas , Pauly Simon 
Published: January 2018

AbstractMartensitic transformations originate from a rigidity instability, which causes a crystal to change its lattice in a displacive manner. Here, we report that the martensitic transformation on cooling in Ti–Zr–Cu–Fe alloys yields an amorphous phase instead. Metastable β-Ti partially transforms into an intragranular amorphous phase due to local lattice shear and distortion. The lenticular amorphous plates, which very much resemble α′/α″ martensite in conventional Ti alloys, have a well-defined orientation relationship with the surrounding β-Ti crystal. The present solid-state amorphization process is reversible, largely cooling rate independent and constitutes a rare case of congruent inverse melting. The observed combination of elastic softening and local lattice shear, thus, is the unifying mechanism underlying both martensitic transformations and catastrophic (inverse) melting. Not only do we reveal an alternative mechanism for solid-state amorphization but also establish an explicit experimental link between martensitic transformations and catastrophic melting.
Advancing behavioural genomics by considering timescale
Authors: Rittschof Clare C. , Hughes Kimberly A. 
Published: January 2018

AbstractAnimal behavioural traits often covary with gene expression, pointing towards a genomic constraint on organismal responses to environmental cues. This pattern highlights a gap in our understanding of the time course of environmentally responsive gene expression, and moreover, how these dynamics are regulated. Advances in behavioural genomics explore how gene expression dynamics are correlated with behavioural traits that range from stable to highly labile. We consider the idea that certain genomic regulatory mechanisms may predict the timescale of an environmental effect on behaviour. This temporally minded approach could inform both organismal and evolutionary questions ranging from the remediation of early life social trauma to understanding the evolution of trait plasticity.
Author Correction: Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses
Authors: Cruz-Adalia Aránzazu , Ramirez-Santiago Guillermo , Osuna-Pérez Jesús , Torres-Torresano Mónica , Zorita Virgina , Martínez-Riaño Ana , Boccasavia Viola , Borroto Aldo , Martínez del Hoyo Gloria , González-Granado José María , Alarcón Balbino , Sánchez-Madrid Francisco , Veiga Esteban 
Published: January 2018

The original version of this Article contained an error in the spelling of the author José María González-Granado, which was incorrectly given as José María Gozález-Granado. This has now been corrected in both the PDF and HTML versions of the Article.
Statistical Approach for Gene Set Analysis with Trait Specific Quantitative Trait Loci
Authors: Das Samarendra , Rai Anil , Mishra D. C. , Rai Shesh N. 
Published: January 2018

AbstractThe analysis of gene sets is usually carried out based on gene ontology terms and known biological pathways. These approaches may not establish any formal relation between genotype and trait specific phenotype. In plant biology and breeding, analysis of gene sets with trait specific Quantitative Trait Loci (QTL) data are considered as great source for biological knowledge discovery. Therefore, we proposed an innovative statistical approach called Gene Set Analysis with QTLs (GSAQ) for interpreting gene expression data in context of gene sets with traits. The utility of GSAQ was studied on five different complex abiotic and biotic stress scenarios in rice, which yields specific trait/stress enriched gene sets. Further, the GSAQ approach was more innovative and effective in performing gene set analysis with underlying QTLs and identifying QTL candidate genes than the existing approach. The GSAQ approach also provided two potential biological relevant criteria for performance analysis of gene selection methods. Based on this proposed approach, an R package, i.e., GSAQ (https://cran.r-project.org/web/packages/GSAQ) has been developed. The GSAQ approach provides a valuable platform for integrating the gene expression data with genetically rich QTL data.