bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of a complex psychosocial intervention for families with parental cancer: acceptability, suitability, implementability, and perceived support
Authors: Ernstmann Nicole , Nakata Hannah , Heier Lina , Heuser Christian , Dohmen Marc , Bremen Rebecca , Geiser Franziska , Holsteg Steffen , Karger Andre , Viehmann Anja , Brüne Manuela , Icks Andrea , Haastert Burkhard , Brümmendorf Tim H. , Petermann-Meyer Andrea 
Published: October 2024

Abstract
Purpose
This study aimed to assess the feasibility of a comprehensive psychosocial intervention for families coping with parental cancer.

Methods
A quasi-experimental trial with intervention and control group, employing a mixed-methods approach, was conducted. A total of 472 families affected by parental cancer participated. The feasibility of the intervention was evaluated based on study monitoring measures (on-site visits, team supervision meeting observations, case conference observations, best practice workshops, coordinating information exchange between intervention sites, and reviewing intervention documentation), process evaluation (semi-structured interviews, focus group discussion) and survey data. Data analysis involved thematic coding and descriptive statistics.

Results
The intervention was well-received by the participating families, with a high degree of acceptance observed. The feasibility of the intervention was found to be associated with specific dynamics within each family system and the motivation of the family members. The success of the intervention was described as dependent on the family-centered arrangement of the encounters, including factors such as frequency, duration, and mode, which greatly influenced its overall acceptability.

Conclusion
The family-scout intervention demonstrates its feasibility as an effective intervention to reduce the burden experienced by families coping with parental cancer. Psychosocial oncology services should continue to develop and implement family-centered interventions to offer support to families during their cancer journey.

Trial registration
ClinicalTrials.gov, NCT04186923. Retrospectively registered on 4 December 2019.
The corticospinal tract in multiple sclerosis: correlation between cortical excitability and magnetic resonance imaging measures
Authors: Kauv Paul , Chalah Moussa A. , Créange Alain , Lefaucheur Jean-Pascal , Hodel Jérôme , Ayache Samar S. 
Published: October 2024

Abstract
Multiple sclerosis (MS) is a central nervous system disease involving gray and white matters. Transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI) could help identify potential markers of disease evolution, disability, and treatment response. This work evaluates the relationship between intracortical inhibition and facilitation, motor cortex lesions, and corticospinal tract (CST) integrity. Consecutive adult patients with progressive MS were included. Sociodemographic and clinical data were collected. MRI was acquired to assess primary motor cortex lesions (double inversion and phase-sensitive inversion recovery) and CST integrity (diffusion tensor imaging). TMS outcomes were obtained: motor evoked potentials (MEP) latency, resting motor threshold, short-interval intracortical facilitation (ICF) and inhibition. Correlation analysis was performed. Twenty-five patients completed the study (13 females, age: 55.60 ± 11.49 years, Expanded Disability Status Score: 6.00 ± 1.25). Inverse correlations were found between ICF mean and each of CST radial diffusivity (RD) (ρ =-0.56; p < 0.01), CST apparent diffusion coefficient (ADC) (ρ=-0.44; p = 0.03), and disease duration (ρ=-0.46; p = 0.02). MEP latencies were directly correlated with disability scores (ρ = 0.55; p < 0.01). High ADC/RD and low ICF have been previously reported in patients with MS. While the former could reflect structural damage of the CST, the latter could hint towards an aberrant synaptic transmission as well as a depletion of facilitatory compensatory mechanisms that helps overcoming functional decline. The findings suggest concomitant structural and functional abnormalities at later disease stages that would be accompanied with a heightened disability. The results should be interpreted with caution mainly because of the small sample size that precludes further comparisons (e.g., treated vs. untreated patients, primary vs. secondary progressive MS). The role of these outcomes as potential MS biomarkers merit to be further explored.
Optimization of electrode thickness of lithium-ion batteries for maximizing energy density
Authors: Khan F. M. Nizam Uddin , Rasul Mohammad G. , Mandal Nirmal K. , Sayem A. S. M. 
Published: October 2024

Abstract
The demand for high capacity and high energy density lithium-ion batteries (LIBs) has drastically increased nowadays. One way of meeting that rising demand is to design LIBs with thicker electrodes. Increasing electrode thickness can enhance the energy density of LIBs at the cell level by reducing the ratio of inactive materials in the cell. However, after a certain value of electrode thickness, the rate of energy density increase becomes slower. On the other hand, the impact of associated limitations becomes stronger, reducing the practical applicability of LIBs with thicker electrodes. Hence, an optimum value of thickness is of utmost importance for the practicability of thicker electrode design. In this paper, both the cathode thickness and the anode thickness of an NCM LIB cell were optimized by applying response surface methodology (RSM) with a Box-Behnken design (BBD) to maximize the energy density. Moreover, the influence of electrode porosity, together with the interaction of porosity with cathode and anode thickness, was incorporated into the optimization. A full factorial design of 3-level, 3-factor was used to generate 15 simulation conditions in accordance with the design of experiment (DoE) achieved through BBD. Then, those conditions were used to achieve 15 responses by simulating a reduced-order electrochemical model. Finally, the statistical technique analysis of variance (ANOVA) was used to analyze and validate the results of RSM. The results show that the RSM-BBD optimization method, coupled with ANOVA, has successfully optimized the thicknesses of both positive and negative electrodes for maximum energy density, despite the nonlinearity of the electrochemical system. The findings suggest an optimized cathode thickness of 401.56 µm and anode thickness of 186.36 µm for a maximum energy density of 292.22 of an NCM LIB cell, while electrode porosity is preferred to be 0.2.
The prospect of floating photovoltaic in clean energy provision and net-zero-emissions
Authors: Ebhota Williams S. , Tabakov Pavel Y. 
Published: October 2024

AbstractThis study emphasizes the critical role of renewable energy in addressing climate change challenges, particularly in reducing greenhouse gas emissions. It highlights the central importance of solar photovoltaic systems. While recognizing South Africa’s progress in renewable energy deployment, the study notes that substantial efforts are still needed to meet the country’s renewable energy targets. The study’s primary aim is to enhance the understanding and deployment of solar photovoltaic systems by critically examining the photovoltaic potential and performance of different sites. To achieve this, two scenarios—land photovoltaic and floating photovoltaic systems—were considered, focusing on hypothetical 10 MWp-installed capacity systems. The results indicate that the 10-MWp land photovoltaic system has a global tilted irradiance of 2184.7 kWh/m2, an annual total output of 18 GWh, and an average yearly performance ratio of 81%. The economic parameters for the land photovoltaic system include a capital expenditure of $9.0 million, an operational expenditure of $157,500 annually, and a levelised cost of energy of $0.04089/kWh. In contrast, the 10-MWp floating photovoltaic system reports a Global Tilted Irradiance of 1797 kWh/m2, an annual total output of 16 GWh, and a performance ratio of 76%. The economic parameters for the floating photovoltaic system include a capital expenditure of $10.6 million, an operational expenditure of $176,250 annually, and a levelised cost of energy of $0.04936/kWh. Both scenarios’ econo-technical parameters fall within acceptable ranges. However, the land photovoltaic system shows better performance, indicating some efficiency loss in the floating photovoltaic system possibly due to harsher offshore conditions. Based on the data from the reports, the study concludes that the econo-technical feasibility of floating photovoltaic in the Western Cape Province of South Africa is high.
Graphical abstract
The cardiac, vasomotor and myocardial branches of the baroreflex in hypotension: indications of reduced venous return to the heart
Authors: Reyes del Paso Gustavo A. , Montoro Casandra I. , Daydov Dmitry M. , Duschek Stefan 
Published: October 2024

Abstract
Purpose
Alterations of autonomic cardiovascular control are implicated in the origin of chronic low blood pressure (BP) (hypotension), but comprehensive analysis of baroreflex function is still lacking. This study explored baroreflex function in its cardiac, vascular and myocardial branches

Methods
Continuous BP was recorded at rest and during a mental arithmetic task in 40 hypotensive and 40 normotensive participants. Assessed cardiovascular variables included stroke volume (SV) (calculated by the Modelflow method), heart rate (HR), cardiac output (CO), total peripheral resistance (TPR) and heart rate variability (HRV). Baroreflex sensitivity (BRS) was calculated using the spontaneous sequence method.

Results
Hypotensive participants exhibited greater BRS in the three baroreflex branches, in addition to lower SV, HR and CO and higher HRV and TPR. Reactivity for BP, HRV and CO during the stress task was reduced in hypotensive individuals. The greater cardiac BRS can explain the lower HR and higher HRV observed in hypotension, suggestive of increased vagal cardiac influences. The higher vasomotor BRS may contribute to the greater TPR observed in the hypotensive participants. Abnormal associations between myocardial BRS and SV arose, suggesting aberrant autonomic control of myocardial contractility in hypotension.

Conclusion
The results indicate that hemodynamic deficits in hypotension are related to preload factors, probably triggered by hypovolemia and reduced unstressed blood reserves, resulting in lower venous return, ventricular preload and SV. In contrast, afterload mechanisms seem to work appropriately.
Association of Racial Residential Segregation and Other Social Determinants of Health with HIV Late Presentation
Authors: Shi Fanghui , Zhang Jiajia , Chen Shujie , Yang Xueying , Li Zhenlong , Weissman Sharon , Olatosi Bankole , Li Xiaoming 
Published: October 2024

Abstract
Understanding social determinants of HIV late presentation with advanced disease (LPWA) beyond individual-level factors could help decrease LPWA and improve population-level HIV outcomes. This study aimed to examine county-level social determinants of health (SDOH) with HIV late presentation. We aggregated datasets for analysis by linking statewide HIV diagnosis data from the South Carolina (SC) Enhanced HIV/AIDS Reporting System and multiple social contextual datasets (e.g., the American Community Survey). All adult (18 years and older) people with HIV diagnosed from 2014 to 2019 in SC were included. Linear mixed models with forward selection were employed to explore the association of county-level SDOH with the county-level three-year moving average percentage of LPWA and average delay time from HIV infection to diagnosis. Around 30% of new HIV diagnoses were LPWA in SC, and the mean delay time for people with LPWA was approximately 13 years. Counties with more racial residential segregation had longer average delay time (Adjusted beta = 5.079, 95% CI: 0.268 ~ 9.889). Regarding other SDOH, the increased percentage of LPWA was associated with fewer Ryan White centers per 100,000 population (Adjusted beta = -0.006, 95% CI: -0.011~-0.001) and higher percentages of the population with less than a high school education (Adjusted beta = 0.008, 95% CI: 0 ~ 0.015). Reducing county-level disparities in LPWA requires multifaceted interventions addressing multiple dimensions of SDOH. Targeted interventions are needed for counties with more Black residential segregation, fewer Ryan White centers, and higher percentages of less than high school education.
Recent applications and advances of African Vultures Optimization Algorithm
Authors: Hussien Abdelazim G. , Gharehchopogh Farhad Soleimanian , Bouaouda Anas , Kumar Sumit , Hu Gang 
Published: October 2024

AbstractThe African Vultures Optimization Algorithm (AVOA) is a recently developed meta-heuristic algorithm inspired by the foraging behavior of African vultures in nature. This algorithm has gained attention due to its simplicity, flexibility, and effectiveness in tackling many optimization problems. The significance of this review lies in its comprehensive examination of the AVOA’s development, core principles, and applications. By analyzing 112 studies, this review highlights the algorithm’s versatility and the growing interest in enhancing its performance for real-world optimization challenges. This review methodically explores the evolution of AVOA, investigating proposed improvements that enhance the algorithm’s ability to adapt to various search geometries in optimization problems. Additionally, it introduces the AVOA solver, detailing its functionality and application in different optimization scenarios. The review demonstrates the AVOA’s effectiveness, particularly its unique weighting mechanism, which mimics vulture behavior during the search process. The findings underscore the algorithm’s robustness, ease of use, and lack of dependence on derivative information. The review also critically evaluates the AVOA’s convergence behavior, identifying its strengths and limitations. In conclusion, the study not only consolidates the existing knowledge on AVOA but also proposes directions for future research, including potential adaptations and enhancements to address its limitations. The insights gained from this review offer valuable guidance for researchers and practitioners seeking to apply or improve the AVOA in various optimization tasks.
Using image-based inspection data to improve response predictions of earthquake-damaged unreinforced masonry buildings
Authors: Haindl Mathias , Smith Ian F. C. , Beyer Katrin 
Published: October 2024

AbstractExplicit representation of uncertainties is essential to improve the reliability of seismic assessments of earthquake-damaged buildings, particularly when dealing with unreinforced masonry buildings. Modern inspection techniques use images for detecting and quantifying the damage to a structure. Based on the principle of falsification, this paper evaluates how the use of information of damage that is obtained from images taken on earthquake-damaged buildings reduces the uncertainty when predicting the seismic response under a future earthquake. New model falsification criteria use information on the residual state of a building, such as shear cracks, residual roof displacements, and observation of out-of-plane failure. To demonstrate the effectiveness of these criteria in reducing the uncertainty in response predictions, results from a four-story unreinforced masonry building stiffened with reinforced concrete walls, which was experimentally tested under a sequence of ground motions, are assessed. Three commonly used modeling approaches (single degree of freedom (DOF) systems, multi DOF systems with four DOFs, and equivalent frame models) are used, where uncertainties in model parameters and model bias are included and propagated through the analysis. Out of the models used, and in the absence of any additional source of information, the proposed falsification criteria are most effective in connection with the equivalent frame model because this model can simulate the response at the element-level, while the simpler models can only represent the global response or the response at the storey-level. The results show that when using only the information on the presence of shear cracks, which might be the first and only source of information after an earthquake, the effectiveness of model falsification is increased, thus reducing the uncertainty in model parameter values and seismic response predictions through the use of image-based inspection.
Turbulent Heat Fluxes over Arctic Sea Ice: Measurements and Evaluation of Recent Parameterizations
Authors: Srivastava P. , Brooks I. M. , Prytherch J. , Salisbury D. J. , Renfrew I. A. , Elvidge A. D. , Yelland M. J. 
Published: October 2024

AbstractWe present direct eddy covariance measurements of the surface heat flux in sea ice over a wide range of conditions across the Arctic Ocean made during two research cruises. Photographic imagery of the surface around the ship provides a local, in situ estimate of the ice fraction. Aerodynamically rough conditions prevail for the majority of the time in the consolidated pack ice. The results are analyzed in the framework of a recently-developed parameterization scheme in which the exchange coefficients over ice are functions of a roughness Reynolds number, R*, hence account for aerodynamic roughness variability. This parameterization accurately represents the measured fluxes under all conditions, while under aerodynamically rough conditions the existing parameterizations from both the Met Office Unified Model, and ECMWF Integrated Forecast System overestimate the fluxes. The results corroborate those of a previous airborne study over the marginal ice zone, and encompass a wider range of atmospheric stability conditions.
Lymphoma in Sub-Saharan Africa: a scoping review of the epidemiology, treatment challenges, and patient pathways
Authors: Baissa Obsie T. , Ben-Shushan Tomer , Paltiel Ora 
Published: October 2024

Abstract
Purpose
Improving cancer outcomes in Sub-Saharan Africa (SSA) requires effective implementation of evidence-based strategies. This scoping review maps the evidence on lymphoma epidemiology, treatment challenges, and patient pathways in SSA from 2011 to 2022.

Methods
A comprehensive three-step search was conducted without language restrictions.

Results
Eighty-four publications were included, 83% published after 2017. Southern and Eastern Africa led in output. Most studies were chart reviews (47.6%) and cohort studies (25%). NHL accounted for over 80% of cases, with an age-standardized rate (ASR) reaching 10.9/100,000, while HL had an ASR of 0.4–2.3/100,000. Compared to studies in Europe and US, SSA studies reported lower incidence rates, higher HIV comorbidity, and younger median ages. Diagnosis is often delayed, incomplete and lacks sub-classification with HIV and tuberculosis further complicating care. One-year survival rates are around 50% for NHL and over 75% for HL. Treatment is well-tolerated with an acceptable treatment-related mortality rate. However, outcomes are affected by diagnostic delays, late presentations, and treatment abandonment. Non-clinical aspects of care such as financial constraints negatively impact patient pathways.

Conclusion
Addressing diagnostic delays, misdiagnosis, and treatment abandonment is crucial. Strengthening care access, diagnostics, and integrating innovative strategies including a multidisciplinary approach and re-designing efficient clinical diagnostic pathways are vital.
The mitral to aortic/pulmonary velocity-time integral ratio is a simple, feasible and accurate discriminator for echocardiographic evaluation of severe isolated mitral regurgitation
Authors: Nerlekar Nitesh , Ramkumar Satish , Maggiore Paul , Teng Justin , Cimenkaya Cengiz , Be Kim Kuy , Baumann Angus , Nicholls Stephen J. , Moir Stuart 
Published: October 2024

AbstractEchocardiographic quantification of mitral regurgitation (MR) remains challenging, requiring dedicated image acquisition, and is limited by potential error from geometric assumptions of annular dimensions. Volume is a product of area and flow and assuming proportional mitral/aortic areas, an increased mitral-inflow volume compared to LV/RV-outflow semi-quantitatively represents greater MR regurgitant volume. Therefore, we investigated the feasibility and diagnostic performance of the mitral-aortic velocity-time integral(VTI) ratio in isolated MR. We also investigated the use of the mitral-pulmonary VTI ratio as an alternative in clinical situations where the LV outflow tract(LVOT) VTI could not be used. We reviewed 166 consecutive patients (33%, n = 54 severe MR by multi-parameter integrated expert opinion). Pulsed wave Doppler VTI at the mitral leaflet tips and the left ventricular outflow and continuous-wave Doppler of the RV outflow tract were measured individually and independently by blinded readers(expert and trainee status) to derive the ratio. Receiver operator characteristic area under the curve(AUC) comparison was calculated and compared with effective regurgitant orifice area(EROA > 40 mm), regurgitant volume(RVol > 60mL), vena contracta(VC > 0.7 cm), E-velocity > 1.2 cm, systolic flow reversal(SFR), left atrial and ventricular dilatation. Increasing ratio was associated with severe MR(AUC 0.94) with optimal threshold defined at 1.3. This provided significant discrimination for severe MR(AUC 0.81) compared to EROA(0.68), VC(0.52), LV dilatation(0.69), LA dilatation(0.70), SFR(0.73), E-velocity(0.68) all p < 0.05, with sensitivity 82% and specificity 94%. The mitral-pulmonary VTI ratio demonstrated similar discrimination(AUC 0.92) with optimal threshold defined at 1.14. Excellent inter-observer reproducibility(intra-class correlation 0.97) was seen between trainee and expert readers. There was no difference in AUC comparison by MR mechanism or patient rhythm. The mitral-aortic and mitral-pulmonary VTI ratios are simple, geometric-free parameters feasibly reproducible from routine echocardiographic datasets and are excellent discriminative tools for severe MR. Readers should consider integration of this parameter in routine reporting.
Distinguishing hypertensive cardiomyopathy from cardiac amyloidosis in hypertensive patients with heart failure: a CMR study with histological confirmation
Authors: Gil Katarzyna Elzbieta , Truong Vien , Liu Chuanfen , Ibrahim Dalia Y. , Mikrut Katarzyna , Satoskar Anjali , Varghese Juliet , Kahwash Rami , Han Yuchi 
Published: October 2024

Abstract
Purpose
Differentiation of the cause of left ventricular hypertrophy (LVH) is challenging in cases with co-existing hypertension. CMR offers assessment of diffuse myocardial abnormalities via T1 mapping with extracellular volume fraction (ECV) and macroscopic fibrosis via late gadolinium enhancement imaging (LGE). The goal of the study was to understand if CMR parameters can differentiate hypertensive cardiomyopathy (HC) from cardiac amyloidosis (CA) in patients with hypertension and heart failure, using endomyocardial biopsy (EMB) as the gold standard.

Methods
We retrospectively analyzed patients with hypertension, LVH, and heart failure undergoing EMB due to uncertain diagnosis. CMR parameters including cine, LGE characteristics, T1 mapping, and ECV were analyzed.

Results
A total of 34 patients were included (mean age 66.5 ± 10.7 years, 79.4% male). The final EMB-based diagnosis was HC (10, 29%), light chain (AL) CA (7, 21%), and transthyretin (ATTR) CA (17, 50%). There was a significant difference in subendocardial LGE (p = 0.03) and number of AHA segments with subendocardial LGE (p = 0.005). The subendocardial LGE pattern was most common in AL-CA (85.7%) and African American with HC (80%). ECV elevation (≥ 29%) was present in all patients with CA (AL-CA: 57.6 ± 5.2%, ATTR-CA: 59.1 ± 15.3%) and HC (37.3 ± 4.5%).

Conclusions
Extensive subendocardial LGE pattern is not pathognomonic for CA but might also be present in African American patients with longstanding or poorly controlled HTN. The ECV elevation in HC with HF might be more significant than previously reported with an overlap of ECV values in HC and CA, particularly in younger African American patients.

Graphical Abstract