bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical methods for solving the first-kind boundary value problem for a linear second-order differential equation with a deviating argument
Authors: Abregov Muhad H. , Kanchukoev Vladimir Z. , Shardanova Maryana A. 
Published: November 2017

Abstract
This work is devoted to the numerical methods for solving the first-kind boundary value problem for a linear second-order differential equation with a deviating argument in minor terms. The sufficient conditions of the one-valued solvability are established, and the a priori estimate of the solution is obtained. For the numerical solution, the problem studied is reduced to the equivalent boundary value problem for an ordinary linear differential equation of fourth order, for which the finite-difference scheme of second-order approximation was built. The convergence of this scheme to the exact solution is shown under certain conditions of the solvability of the initial problem. To solve the finite-difference problem, the method of five-point marching of schemes is used.
Crystal structure of 4-chloro-2-methyl-6-(4-(trifluoromethoxy)phenyl)pyrimidine, C12H8ClF3N2O
Authors: Bertrand Jean-Luc , Salas Cristian O. , Brito Iván 
Published: November 2017

Abstract
C12H8ClF3N2O, tetragonal, I4̅ (no. 82), a = 23.280(6) Å, c = 4.7191(15) Å, V = 2557.6(15) Å3, Z = 8, Rgt
= 0.0700, wR
ref(F
2) = 0.1933, T = 296(2) K.
The crystal structure of bis(2-benzoyl-5-hydroxylphenolato-κ2
O,O′)copper(II), C26H18CuO6
Authors: Wang Hui , Xiao Zi-Jing 
Published: November 2017

Abstract
Cu(C13H9O3)2, tetragonal, I41/a (no. 88), a = 14.2364(4) Å, c = 20.5410(7) Å, V = 4163.1(3) Å3, Z = 8, R
gt(F) = 0.0482, wR
ref(F
2) = 0.1476, T = 293 K.
Can the EU’s constitutional framework accommodate democratic politics?
Authors: Scicluna Nicole 
Published: November 2017

AbstractThe robustness of the EU’s constitutional framework – and its ability to accommodate democratic politics – is challenged as never before. The growing disconnect between formally democratic procedures and substantive choice is well illustrated by the Greek crisis. Since its first bailout in May 2010, Greece has held four general elections and a referendum. Yet, the anti-austerity preferences of the Greek electorate have not been effectively translated into policy.This article uses the Greek crisis to analyse the EU’s democratic deficit, and the related issue of the locus of legal and political sovereignty in the EU. It argues that the EU’s constitutional framework is not sufficiently responsive to changing material conditions or to the changing preferences of Europeans. Thus, EU constitutionalism needs to be refashioned in order to strike a better balance between democratic and technocratic governance, as well as between the needs of individual citizens, national citizenries, and states.
How to Bridge the Gaps between Competing Paradigms for EU Law: An Introduction
Authors: Simoncini Marta , Straetmans Gert 
Published: November 2017

AbstractFor the first time since its creation, the European Union (EU) has been living its probably most significant identity crisis. This crisis has its roots in different critical situations that have hit the EU, have affected its functioning and have fundamentally questioned its legitimacy. The gaps in the EU integration process have been uncovered and the fragmentation of EU policies has become a source of different risks.On the anniversary of sixty years of the Rome Treaties, this Special Issue aims to reflect on the paradigms for EU law looking beyond their competing accounts of EU integration. The analysis is developed through a series of contributions that challenge the paradigms in different directions. The discussion is articulated on two levels. On the one hand, a group of contributions focuses on the historical and legal analysis of the emergence and transformation of the EU legal order. These contributions delve deeper into the absence of a European identity and go beyond the inherent critique that the EU is ademoi-cracy that struggles with a democratic disconnect or even deficit. On the other hand, other contributions debate paradigms and their implementation in important policy domains. These contributions aim to give a more practical perspective on the constitutional and/or administrative character of the European Union, showing its implications and concrete questions.
Assessment of R18, COG1410, and APP96-110 in excitotoxicity and traumatic brain injury
Authors: Chiu Li Shan , Anderton Ryan S. , Cross Jane L. , Clark Vince W. , Edwards Adam B. , Knuckey Neville W. , Meloni Bruno P. 
Published: November 2017

AbstractCationic arginine-rich and poly-arginine peptides (referred to as CARPs) have potent neuroprotective properties in in vitro excitotoxicity and in vivo models of stroke. Traumatic brain injury (TBI) shares many pathophysiological processes as stroke, including excitotoxicity. Therefore, we evaluated our lead peptide, poly-arginine R18, with the COG1410 and APP96-110 peptides, which have neuroprotective actions following TBI. In an in vitro cortical neuronal glutamic acid excitotoxicity injury model, R18 was highly neuroprotective and reduced neuronal calcium influx, while COG1410 and APP96-110 displayed modest neuroprotection and were less effective at reducing calcium influx. In an impact-acceleration closed-head injury model (Marmarou model), R18, COG1410, and APP96-110 were administered intravenously (300 nmol/kg) at 30 minutes after injury in male Sprague-Dawley rats. When compared to vehicle, no peptide significantly improved functional outcomes, however the R18 and COG1410 treatment groups displayed positive trends in the adhesive tape test and rotarod assessments. Similarly, no peptide had a significant effect on hippocampal neuronal loss, however a significant reduction in axonal injury was observed for R18 and COG1410. In conclusion, this study has demonstrated that R18 is significantly more effective than COG1410 and APP96-110 at reducing neuronal injury and calcium influx following excitotoxicity, and that both R18 and COG1410 reduce axonal injury following TBI. Additional dose response and treatment time course studies are required to further assess the efficacy of R18 in TBI.
Paul Silas Peterson: A third time, Erich Przywara, the Jews and Stimmen der Zeit: With a response to Aaron Pidel and a brief look into Przywara’s late letters to Carl Schmitt
Authors: Peterson Paul Silas 
Published: November 2017

Abstract
In diesem Aufsatz werden die Veröffentlichungen des Jesuiten Erich Przywara und der sehr einflussreichen jesuitischen Zeitschrift Stimmen der Zeit aus den frühen 193oern Jahren und besonders aus dem Jahr 1933 analysiert. In diesem Zusammenhang antworte ich auch meinen Kritikern. Außerdem werden die Hintergründe und Quellen der spezifischen Form des Antisemitismus dargestellt, die in den Stimmen der Zeit vertreten wurde. Deutsche Jesuiten propagierten 1933 durchaus radikale Positionen in der Zeitschrift. In dem katholischen Blatt liest man u. a., dass die Juden dem deutschen Volk mehr Schaden als Nutzen brächten. Es wurde damals auch die nordische Rasse als für Herrschaft besonders geeignet bezeichnet. Im letzten Teil dieses Aufsatzes werden Przywaras spätere Briefe an Carl Schmitt, den gläubigen antisemitischen deutschen Katholiken, analysiert. Sie zeigen, dass Przywara von dessen antidemokratischer politischer Theorie der 1930er Jahre zutiefst beeindruckt war und die Ideen des Kronjuristen des Dritten Reiches sogar noch in der Zeit nach dem Zweiten Weltkrieg verbreiten wollte.
Genotyping by Sequencing in Almond: SNP Discovery, Linkage Mapping, and Marker Design
Authors: Goonetilleke Shashi N , March Timothy J , Wirthensohn Michelle G , Arús Pere , Walker Amanda R , Mather Diane E 
Published: November 2017

Abstract
In crop plant genetics, linkage maps provide the basis for the mapping of loci that affect important traits and for the selection of markers to be applied in crop improvement. In outcrossing species such as almond (Prunus dulcis Mill. D. A. Webb), application of a double pseudotestcross mapping approach to the F1 progeny of a biparental cross leads to the construction of a linkage map for each parent. Here, we report on the application of genotyping by sequencing to discover and map single nucleotide polymorphisms in the almond cultivars “Nonpareil” and “Lauranne.” Allele-specific marker assays were developed for 309 tag pairs. Application of these assays to 231 Nonpareil × Lauranne F1 progeny provided robust linkage maps for each parent. Analysis of phenotypic data for shell hardness demonstrated the utility of these maps for quantitative trait locus mapping. Comparison of these maps to the peach genome assembly confirmed high synteny and collinearity between the peach and almond genomes. The marker assays were applied to progeny from several other Nonpareil crosses, providing the basis for a composite linkage map of Nonpareil. Applications of the assays to a panel of almond clones and a panel of rootstocks used for almond production demonstrated the broad applicability of the markers and provide subsets of markers that could be used to discriminate among accessions. The sequence-based linkage maps and single nucleotide polymorphism assays presented here could be useful resources for the genetic analysis and genetic improvement of almond.
RNA-Sequencing ofDrosophila melanogasterHead Tissue on High-Sugar and High-Fat Diets
Authors: Hemphill Wayne , Rivera Osvaldo , Talbert Matthew 
Published: November 2017

AbstractObesity has been shown to increase risk for cardiovascular disease and type-2 diabetes. In addition, it has been implicated in aggravation of neurological conditions such as Alzheimer’s. In the model organism Drosophila melanogaster, a physiological state mimicking diet-induced obesity can be induced by subjecting fruit flies to a solid medium disproportionately higher in sugar than protein, or that has been supplemented with a rich source of saturated fat. These flies can exhibit increased circulating glucose levels, increased triglyceride content, insulin-like peptide resistance, and behavior indicative of neurological decline. We subjected flies to variants of the high-sugar diet, high-fat diet, or normal (control) diet, followed by a total RNA extraction from fly heads of each diet group for the purpose of Poly-A selected RNA-Sequencing. Our objective was to identify the effects of obesogenic diets on transcriptome patterns, how they differed between obesogenic diets, and identify genes that may relate to pathogenesis accompanying an obesity-like state. Gene ontology analysis indicated an overrepresentation of affected genes associated with immunity, metabolism, and hemocyanin in the high-fat diet group, and CHK, cell cycle activity, and DNA binding and transcription in the high-sugar diet group. Our results also indicate differences in the effects of the high-fat diet and high-sugar diet on expression profiles in head tissue of flies, despite the reportedly similar phenotypic impacts of the diets. The impacted genes, and how they may relate to pathogenesis in the Drosophila obesity-like state, warrant further experimental investigation.
The Vocation to Parenthood in the Context of a Demographic Crisis in Poland
Authors: Świerczek Antoni 
Published: November 2017

The vocation to parenthood is a constitutive element of married and family life. However, recent decades show that the number of births in Poland is declining steadily. This, in turn, is leading to a decrease in population and population aging in our homeland. The current situation is called a demographic catastrophe, the consequences of which will be felt in the next decades. It is therefore necessary to take concrete steps to change this situation. The aims of this article are to try to describe the present demographic situation in Poland, to recall the main ideas of the teaching of the Catholic Church on the parental tasks of the family and society, and to identify the most important pastoral task, which the Church in Poland faces in this regard.
The Dilemmas of Christian Feminism
Authors: Świerczek Magdalena 
Published: November 2017

The aim of the article is to discuss selected issues of Christian feminism which attempt to reconcile traditional women’s roles in a society with the idea of emancipation. The article is composed of four parts. The first one discusses the basic theses of Christian feminism. The second one includes deliberations on biblical and theological evidence for women’s and men’s statuses. The third and fourth part offer an analysis of biblical examples of women’s autonomy and the postulate of women’s emancipation in the Christian work ethos.
Muzyka sakralna jako via pulchritudinis wyzwaniem dla kompozytorów
Authors: Bramorski Jacek 
Published: November 2017

Jeśli natura i kosmos są odblaskiem piękna Stwórcy i prowadzą nas do kontemplacji Jego wielkości, to również twórczość artystyczna ma możliwość przybliżania nas do tajemnicy Boga. Dla człowieka wierzącego piękno wykracza poza estetykę i odnajduje swój archetyp w Bogu. Kontemplacja odwiecznej piękności jest źródłem, z którego kompozytorzy chrześcijańscy czerpią natchnienie, aby ukazywać w swej twórczości misterium Boga. Inspirowane wiarą chrześcijańską dzieła muzyki sakralnej pozwalają nam w intuicyjny sposób uczestniczyć w doświadczeniu wiary, odkrywając tajemnicę miłości Boga i tożsamości człowieka. Posługując się językiem piękna, dzieła muzyczne są nie tylko nośnikami przesłania artysty, ale także prawdy o Bogu. Kompozytor, ukazując ową prawdę, nie wychwala samego siebie, ale pragnie uwielbiać Źródło Piękna. W liturgii, będącej istotnym momentem w doświadczaniu dojrzałej wiary, piękna nie można zredukować jedynie do formalnego estetyzmu. Jest to przede wszystkim głębokie piękno spotkania z tajemnicą Boga. Dlatego w muzyce liturgicznej nie ma miejsca na powierzchowność, banalność i niedbałość. Muzyka nie pomagałaby wówczas w rozwoju wiary, ale wręcz stawałaby się przeszkodą w godnym uczestniczeniu w chrześcijańskich obrzędach. Piękno stanowi zatem jedną z fundamentalnych kategorii teologicznych, pomagając wzrastać w wierze oraz dążyć do prawdy. Istotną rolę ewangelizacyjną pełni w tym kontekście muzyka sakralna, która jako via pulchritudinis stanowi wspaniały wyraz wiary, nadziei i miłości.
Instytucja Kościoła w przestrzeni muzycznej Feliksa Nowowiejskiego
Authors: Dulisz Ilona 
Published: November 2017

Życie i twórczość Feliksa Nowowiejskiego, czołowego kompozytora muzyki religijnej pierwszej połowy XX w. w Polsce, nierozerwalnie wiąże się z Kościołem katolickim. Religijna atmosfera domu rodzinnego, nauka w placówkach kościelnych, praca na stanowiskach organisty, szerokie kontakty w kręgach duchowieństwa, w tym z najwyższymi hierarchami kościelnymi, to istotne determinanty działalności artystycznej kompozytora. W latach II Rzeczypospolitej Nowowiejski nieustanne obecny był w życiu Kościoła i Narodu Polskiego, dla którego Bóg i Ojczyzna stanowiły jedność. Ogromny dorobek kompozytorski, wyrosły w dużej mierze z tradycji religijnych, przyniósł mu liczne nagrody i wyróżnienia.
Poznanie naukowe a prawda absolutna. Krytyka argumentu za istnieniem Boga Siemiona L. Franka
Authors: Sajdek Zofia 
Published: November 2017

According to a Russian philosopher Siemion Frank, there is no such thing as “truth” in science without making a pre­‑assumption about the existence of some kind absolute, and in Frank’s eyes “absolute” always equals “God”. That is why you cannot be an atheist and scientist at the same time. The article is an attempt to show that it is not a proper notion of what science is or should be because: 1) science does not need any idea of truth (maybe philosophy of science does), 2) a consistent notion of truth can be formulated without any notion of absolute, 3) “absolute” not always equals “God”, or even “transcendence”.
PROTECTIVE EFFECTS OF CISTANCHES HERBA AQUEOUS EXTRACT ON CISPLATIN-INDUCED PREMATURE OVARIAN FAILURE IN MICE
Authors: Pan Pengyu , Wang Ying , Leng Xue , Deng Jinfang , Wang Chun 
Published: November 2017

Background: Chemotherapeutic treatment of premenopausal women has been linked to premature ovarian failure (POF). Cistanches Herba (CH) is a commonly used male impotence and female infertility treatment in China; however, whether CH protects ovaries from chemotherapeutic drug-induced POF remains unclear. In this study, we investigated the protective effects of CH in a mouse model of chemotherapeutic drug-induced POF.
Materials and Methods: We administered low- and high-concentration CH to cisplatin-induced POF mice for 2 weeks and determined body and ovarian weights, as well as serum follicle-stimulating hormone (FSH) and estradiol concentrations, to evaluate ovarian function. In addition, we evaluated the protective mechanisms of CH by detecting the levels of apoptosis-related proteins and evaluating markers of mitochondrial function.
Results: In POF mice, we observed reduced body and ovarian weights; elevated serum FSH and attenuated estradiol concentrations; apoptosis of ovarian granulosa with concomitant changes in apoptosis-related proteins (including caspase-3, poly adenosine diphosphate-ribose polymerase, Bcl-2, and Bax); and mitochondrial dysfunction, such as a reduction in mitochondrial numbers, destruction of ultrastructural morphology, decrease in ATPase activity, and decreases in mitochondrial membrane potential and mitofusin-2 (a mitochondria dynamin-like GTPase). Significantly, CH reversed, to an extent, functional and morphologic injuries and ovarian tissue apoptosis by up-regulating the level of Mfn2 and the ratio of Bcl-2/Bax. Furthermore, CH reduced cisplatin-induced mitochondrial dysfunction in ovarian tissues.
Conclusion: The present findings showed that CH inhibited cisplatin-induced POF through interactions between Mfn2 and Bcl-2/Bax proteins and, possibly, by up-regulation of Mfn2 expression. Ultimately, CH protects ovarian tissues from cisplatin-induced apoptosis.
ANTI-DIABETIC AND ANTIOXIDANT POTENTIALS OF AQUEOUS EXTRACT OF EUCALYPTUS GLOBULUS IN EXPERIMENTALLY-INDUCED DIABETIC RATS
Authors: Saka W.A , Akhigbe R.E , Ajayi A.F , Ajayi L.O , Nwabuzor O.E 
Published: November 2017

Background: Evaluation of the medicinal uses of plants remains a growing field of research. This study investigated
the effects of Eucalyptus globules on alloxan -induced diabetic rats.
Materials and Methods: Thirty male albino rats were randomized into 5 groups (n=6). Group A served as the control
and was maintained on standard rat chow and water ad’libitum. Diabetes was induced in Group C, D and E animals by
intraperitoneal administration of alloxan monohydrate (150 mg/kg). Groups B and D were orally administered with
aqueous extract of Eucalyptus globulus at a dose of 150 mg/kg per oral daily for 4 weeks, while group E received
glibenclamide at a dose of 0.6 mg/kg orally in addition. Fasting plasma glucose, antioxidant status (catalase and
xanthine), malondialdehyde (MDA), liver function enzymes (AST and ALT) and bicarbonate ion (HC03
-) were
assessed after 4 weeks.
Results: Aqueous extract of Eucalyptus globulus leaves significantly reduced fasting plasma glucose level, MDA,
HC03
-, and liver enzymes (P
BIOACTIVITY OF ESSENTIAL OILS FROM MEDICINAL PLANTS OF CAMEROON AND THEIR COMBINATION AGAINST INFANT DIARRHEA INDUCED BY BACTERIA
Authors: Ascension Nyegue Maximilienne , Del Florence Moni Ndedi Esther , Florentine Ndoyé-Foe , Fronçois-Xavier Etoa , Menut Chantal 
Published: November 2017

Background: In Cameroon, one of the most common childhood illnesses after malaria is diarrhea, which generally has
a bacterial origin. In rural areas, plant utilization is often one of the first ways of treatment though, with no scientific
bases. Therefore, the aim of this work was to evaluate the antibacterial activities of nine essential oils (EOs) of
Cameroonian plants and their combinations against some strains responsible for diarrhea.
Material and Methods: To determine the bacterial species generally involved in childhood diarrheal infections, a
retrospective study was done. The EOs of Eucalyptus globulus, Cymbopogon citratus, Xylopia aethiopica, Thymus
vulgaris, Ocimum canum, Cananga odorata, Citrus medica, Citrus paradisi and Citrus reticulata were screened against
the most incriminated bacterial species using the spot-on-agar test and microdilution methods. Some of the EOs with
good antibacterial activity were analyzed by Gas Chromatography and Gas Chromatography/Mass Spectrometry.
According to their composition, Thymus vulgaris and Eucalyptus globulus EOs were combined with that of
Cymbopogon citratus using the ratios 2/1; 1/1; 1/2 (w/w) and tested against on bacterial growth.
Results: The retrospective study showed that 10.8% of infant diarrhea was caused by Escherichia coli, Salmonella
typhimurium and Salmonella paratyphimurium. The Minimum inhibition Concentrations (MIC) of single EOs was
between 0.78 and 25 mg/mL which were observed to be greater than those of their combinations which ranged between
0.195 and 6.52 mg/mL. The active essential oils contained mainly hydrocarbonated and oxygenated monoterpens.
Conclusion: The good antibacterial effects of two Thymus combinations Th1 and Th2 observed on Salmonella
typhimurium and Salmonella paratyphimurium suggest their used in aromatherapy to cure bacterial diarrhea.
ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE PROPERTIES OF HYDRO-METHANOL EXTRACT OF EREMOMASTAX SPECIOSA (HOCHST.) CUFOD LEAF
Authors: Onoja Samuel O. , Eke Chinemerem , Ejiofo Emmanuel , Madubuike Kelechi G. , Ezeja Maxwell I. , Omeh Yusuf N. , Anaga Aruh O. 
Published: November 2017

Background: Eremomastax speciosa (Hochst.) Cufod is a perennial herb found in Africa along the rainforest zone and occurs as weed. It is cultivated in Cameroon and Akwa-Ibom in Nigeria due to its medicinal values. This study investigated the antioxidant, anti-inflammatory and antinociceptive properties of hydromethanol extract of Eremomastax speciosa (Hochst.) Cufod leaf in rat model.
Materials and Methods: The plant material was extracted using cold maceration method in 80% hydromethanol. The acute oral toxicity test was performed using Up and Down method with limit dose of 2000 mg/kg. The in vitro antioxidant property was evaluated with 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power photometric assays. The anti-inflammatory potential was investigated in egg-albumin and carrageenan induced paw edema models while the antinociceptive activity was determined using acetic acid induced writhing reflex and tail immersion tests at the doses of 50, 100 and 200 mg/kg. The negative control group (group A) received distilled water (vehicle) at 5 ml/kg while acetyl salicylic acid (200 mg/kg) was used as the reference drug for the anti-inflammatory models and acetic acid induced writhing reflex model while pentazocine (5 mg/kg) was used as the reference drug for tail immersion test.
Results: The LD50 of the extract was greater than 2000 mg/kg. The extract (25 to 400 μg/ml) demonstrated potent antioxidant activities in both the 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power assays. The E. speciosa extract caused significant (P < 0.05) anti-inflammatory and antinociceptive activities in the extract treated groups when compared to rats that received distilled water. The optimal activities of the extract were produced at the dose of 100 mg/kg.
Conclusion: The study supports the folkloric use of Eremomastax speciosa leaf in the management of pain and inflammatory conditions in traditional medicine.