bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin cancer in Europe today and challenges for tomorrow
Authors: Brochez Lieve , Volkmer Beate , Hoorens Isabelle , Garbe Claus , Röcken Martin , Schüz Joachim , Whiteman David C. , Autier Philippe , Greinert Rüdiger , Boonen Brigitta 
Published: October 2024

AbstractOne in every three cancers diagnosed is a skin cancer. Europe has the global lead in the number of UV‐attributable cancer cases with the highest number of melanoma cases worldwide and the second highest number of keratinocyte cancers (KC). Further increases are expected in Europe for the coming decades. Projected increases are highest for KC with increases in incidence around 40% and increases in mortality around 50%, with KC mortality in males approximating melanoma mortality in females. The two main drivers for this skin cancer epidemic are ageing of the population but especially UV exposure. In conclusion, skin cancer represents a major challenge in the cancer field in Europe today and will continue to do so in the coming decades. This calls for a European skin cancer action plan intended to reduce avoidable UV exposure and to prepare the healthcare system to safeguard early diagnosis and treatment of skin cancer.
Dividend mispricing: Evidence from all‐stock merger deals
Authors: Joseph Kerron , Kadapakkam Palani‐Rajan 
Published: October 2024

AbstractStock prices of targets in all‐stock merger deals should reflect acquirer share values, net of expected dividend payments before deal completion. This setting provides a unique opportunity to examine whether market prices of target stocks reflect the price reducing impact of impending acquirer dividends. We find evidence that target stock returns on the acquirer ex‐day are negatively related to the size of the dividend payments, indicating an incomplete adjustment on the last cum‐day. However, given the size of typical quarterly dividends, the magnitude of the estimated 30% incomplete adjustment to the dividend does not represent a viable arbitrage opportunity. Examining a longer window, we find that roughly 70% of the acquirer dividend is incorporated into the target stock price in the period two days after the dividend announcement to the ex‐day. Overall, our results are consistent with target stock prices adjusting slowly over time to reflect impending acquirer dividends.
Assessment of carbon emissions and reduction potential in China's copper smelting industry
Authors: Gao Rong , Shi Yao , Cao Chun , Li Huiquan , Xie Yuanbo , Shi Jingjing , Zhang Chenmu , Guan Xue 
Published: October 2024

AbstractAs the largest producer and consumer of copper, China is facing enormous challenges from carbon peaking and neutrality. This article adopts “bottom‐up” and “top‐down” methods to construct a more accurate model, to predict the CO2 emissions of China's copper smelting industry, and explores its potential for carbon reduction in the future from three scenarios as the baseline scenario (BAU), the general low‐carbon (NLC), and the enhanced low‐carbon (ELC). The results show that the CO2 emissions can achieve a peak in 2028 either in NLC or ELC scenarios, with a peak range of 14.9–16.88 million tonnes. Prior to reaching the peak, the contributions of energy adjustment, material substitution, and process selection to carbon reduction have significantly improved, and the contribution rates increased from 30.91%, 4.11%, and 1.46% to 42.7%, 32.07%, and 15.63% in ELC scenario. After the peak, the contribution of energy adjustment gradually slows down, while the material substitution continues to increase, and the contribution rates increased from 21.25% and 32.07% to 29.38% and 40.01% in NLC and ELC scenarios. In the future, concentrate oxygen‐enriched bottom‐blowing smelting and direct refining from waste copper anode furnaces show ideal potential for carbon reduction before 2025, increasing the proportion of recycled copper production, and adjusting energy structure will be more effective from 2025 to 2035. The conclusions of this study can provide a scientific basis for formulating policy recommendations for green and low‐carbon development of the copper industry in China and all over the world in the future.
Exploring the effect of Guarantees of Origin on the decarbonization of corporate electricity procurement: A case study of Germany and Norway
Authors: Paris Aaron , Hechelmann Ron‐Hendrik , Buchenau Nadja 
Published: October 2024

AbstractIncreasing social, economic, and political pressure causes many companies to pledge to decarbonize. A common measure involves the use of Energy Attribute Certificates (EAC), such as the European Guarantees of Origin (GO), to reduce emissions from electricity procurement (Scope 2). However, previous studies find no effect on additional renewable energy capacity. Focusing on Norway and Germany as dominant contributors to net GO exports and imports, this study examines the GO trade alongside corporate carbon accounting data to answer the research question: Does the decarbonization of corporate electricity procurement using Guarantees of Origin contribute to the expansion of renewable electricity generation capacity in Norway and Germany? The analysis of CDP and Association of Issuing Bodies data reveals Norway's consumption mix is more carbon intensive than Germany's because Norway exports GO and imports fossil electricity attributes. German companies report predominantly market‐based approach, mainly using green tariffs and GO for zero emission claims, while Norwegian companies favor the location‐based approach. The largest share of GO issued in Norway comes from hydropower plants aged 41 to 70 years. The results highlight the urgency to revise corporate carbon accounting standards. GO lack additionality due to double counting of renewable attributes. Potential solutions include additionality criteria, GO trade restrictions based on physical capacities, and age limits for eligible power plants. This study's novelty is linking CDP data with GO trade, to assess the integrity of corporate decarbonization strategies. It contributes valuable insights to ongoing discourse on the role of EAC.
A gender perspective on the circular economy: A literature review and research agenda
Authors: Palm Jenny , Lazoroska Daniela , Valencia Melanie , Bocken Nancy , Södergren Karolina 
Published: October 2024

AbstractThe circular economy (CE) challenges the traditional linear economic model by emphasizing the importance of resource efficiency, recycling, and regeneration in society. However, the role of gender in CE practices remains underexplored. This article presents a systematic literature review on how gender dynamics intersect with CE, highlighting the implications of gendered labor distribution, access to resources, and decision‐making processes. Women, often pivotal in household and community resource management, are underrepresented in policy and research. Gender perspectives are therefore crucial for addressing social, environmental, and justice dimensions within CE. The study employs the lens of care labor to reveal power imbalances and the exclusion of marginalized groups, advocating for inclusive policies to achieve socially sustainable and equitable CE futures. The review identifies the overrepresentation of women in undervalued, informal activities and the dominance of men in highly valued, technologically advanced CE roles. It also underscores the benefits of gender diversity in corporate governance, which enhances sustainability practices. The article calls for a deeper examination of gender's impact on CE, suggesting a research agenda to integrate gender perspectives, enhance CE effectiveness, and promote equity. The findings indicate that addressing gender inequalities in CE is essential to prevent replicating the shortcomings of the linear economy and to foster innovative, inclusive, and sustainable development.
Examining global biodiversity accounts: Implications of aggregating characterization factors from elementary flows in multi‐regional input–output analysis
Authors: Davin Killian , Koslowski Maximilian , Dorber Martin , Hertwich Edgar 
Published: October 2024

AbstractExtending multi‐regional input–output (MRIO) models with spatially explicit life cycle impact assessment (LCIA) models allows practitioners to quantify biodiversity impacts at every step of global supply chains. Inconsistencies may be introduced, however, when high‐resolution characterization factors (CFs) are aggregated so as to match the low spatial granularity of MRIO models. These aggregation errors are greater when CFs are aggregated via proxies, such as ecoregion land shares, instead of based on spatially explicit elementary stressor flows. Here, we describe our approach to tailoring application‐specific CFs for use in MRIO studies. We apply a global agricultural production model, Spatial Production Allocation Model (MapSPAM), with the LCIA database, LC‐IMPACT, to create crop‐specific national CFs. We investigated i) if the differing aggregation approaches and the increased spatial explicitness of the constructed CFs deviate substantially from those in LC‐IMPACT, and ii) what the resulting consequences for national production and consumption‐based biodiversity footprints are when combining the tailor‐made CFs with the EXIOBASE MRIO model. For the year 2020, we observe an increase in global production‐based biodiversity impacts of 23.5% for land use when employing crop‐specific CFs.
Scenario analysis of supply‐ and demand‐side solutions for circular economy and climate change mitigation in the global building sector
Authors: Pauliuk Stefan , Carrer Fabio , Heeren Niko , Hertwich Edgar G. 
Published: October 2024

AbstractResidential and non‐residential buildings are a major contributor to human well‐being. At the same time, buildings cause 30% of final energy use, 18% of greenhouse gas emissions (GHGE), and about 65% of material accumulation globally. With electrification and higher energy efficiency of buildings, material‐related emissions gain relevance. The circular economy (CE) strategies, narrow, slow, and close, together with wooden buildings, can reduce material‐related emissions. We provide a comprehensive set of building stock transformation scenarios for 10 world regions until 2060, using the resource efficiency climate change model of the stock–flow–service nexus and including the full CE spectrum plus wood‐intensive buildings. The 2020–2050 global cumulative new construction ranges from 150 to 280 billion m2 for residential and 70‐120 billion m2 for non‐residential buildings. Ambitious CE reduces cumulative 2020–2050 primary material demand from 80 to 30 gigatons (Gt) for cement and from 35 to 15 Gt for steel. Lowering floor space demand by 1 m2 per capita leads to global savings of 800‐2500 megatons (Mt) of cement, 300‐1000 Mt of steel, and 3‐10 Gt CO2‐eq, depending on industry decarbonization and CE roll‐out. Each additional Mt of structural timber leads to savings of 0.4‐0.55 Mt of cement, 0.6‐0.85 Mt of steel, and 0.8‐1.8 Mt CO2‐eq of system‐wide GHGE. CE reduces 2020–2050 cumulative GHGE by up to 44%, where the highest contribution comes from the narrow CE strategies, that is, lower floorspace and lightweight buildings. Very low carbon emission trajectories are possible only when combining supply‐ and demand‐side strategies. This article met the requirements for a gold‐gold JIE data openness badge described at http://jie.click/badges.
My job characteristics make me procrastinate or not: An emotional perspective
Authors: Wang Yangxin , Zhang Hong , Wang Zhen 
Published: October 2024

AbstractWorkplace procrastination is a prevalent phenomenon that significantly impacts employee productivity and organizational competitiveness. Drawing on cognitive–motivational–relational theory, this study adopts an emotional perspective to investigate how and when job characteristics (i.e. hindrance job demands, challenge job demands and job resources) impact employees' workplace procrastination in distinct ways. We suggest that both hindrance and challenge demands may evoke fear of tasks, eliciting an action tendency of escape and avoidance, thus indirectly leading to procrastination. Notably, challenge demands may exhibit a dual effect by simultaneously enhancing interest in tasks with an action tendency of exploration, thus negatively and indirectly influencing procrastination. Job resources may generate joy about tasks, fostering an action tendency of free activation, thereby indirectly reducing procrastination. We further investigate how psychological capital, which largely shapes employees' appraisal of job characteristics, may alter the above relationships. We conducted two studies to examine our hypotheses and delve into the potential reversed relationships between job characteristics and procrastination. Theoretical and practical implications are discussed.
Prognostic Significance of Programmed Cell Death‐Ligand 1 Expression in Tobacco Associated Oral Squamous Cell Carcinoma: An Immunohistochemical Based Cross‐Sectional Study
Authors: N. Naga Naveena , Mohanty Sweta , Das Surya Narayan , Rath Rachna , Narayanan Sri Priya 
Published: October 2024

ABSTRACTBackgroundAdvancements in immuno‐oncology have dramatically transformed cancer treatment. Immunotherapy, targeting immune check point proteins, notably Programmed cell death ligand 1 (PD‐L1) and its receptor Programmed Cell Death‐1 (PD‐1) which modulate the activity of immune response in Head and Neck squamous cell carcinomas (HNSCC), is an area of much research. The immunohistochemical expression of PD‐L1 in cancer cells has been proposed as a predictive biomarker for selecting candidates for immunotherapy. Thus, the present study was undertaken to study the expression of PD‐L1 in the primary tumour cells and evaluate its correlation with various clinicopathological parameters and prognosis in tobacco associated oral squamous cell carcinomas (OSCC).MethodsExpression of PD‐L1 was investigated in 75 surgically resected cases of OSCC by immunohistochemistry and its association with different clinicopathological features and prognosis was analysed.ResultsPD‐L1 protein was detected in 68% (51 cases) of cases. Tumour stage (p = 0.04), lymph node (LN) metastasis (p < 0.01) and moderate to marked tumour infiltrating lymphocytes (TILs) (p < 0.05), significantly correlated with the PD‐L1 expression in the primary tumour. PD‐L1 expression did not show a significant association with overall survival (OS) rate, however, patients with positive PD‐L1 expression showed a poorer survival rate. Patients exhibiting nodal positivity had the worst prognosis (p < 0.005).ConclusionThese data demonstrated a significant association of ≥ 5% PD‐L1 expression in the primary tumour and the presence of LN metastasis, moderate to marked TILs and advancing tumour stage, thus, making it a plausible immunotherapeutic target molecule in OSCC patients.
Smartphone application‐delivered cognitive behavioural therapy for insomnia with telephone support for insomnia disorder compared to a waitlist control: a randomised clinical trial
Authors: Jansson‐Fröjmark Markus , Sunnhed Rikard 
Published: October 2024

SummaryAlthough there have been promising findings for smartphone application (app)‐delivered cognitive behavioural therapy for insomnia (CBT‐I), previous trials have not screened participants rigorously for insomnia disorder and used therapist support. Based on the above, we aimed to examine the effects of smartphone app‐delivered CBT‐I with telephone support against a waitlist (WL) in a sample with insomnia disorder. A total of 64 participants with insomnia disorder were randomised to smartphone app‐delivered CBT‐I (n = 32) or a WL (n = 32). Smartphone app‐delivered CBT‐I consisted of six weekly smartphone app modules with 15 min of telephone support per week. At pre‐ and post‐treatment, and the 3‐month follow‐up, we assessed insomnia symptoms and associated correlates and consequences. At post‐treatment, we also assessed measures related to adherence (therapist support, exercise/module completion), self‐rated perception of treatment content, activity, and adverse events. CBT‐I significantly outperformed the WL with large effects on the primary outcome (d = 2.26) and was significantly different on most of the secondary outcomes with medium to large effects. CBT‐I also resulted in a significantly larger proportion of treatment remitters (CBT‐I: 64.5–77.4%, WL: 6.5–6.9%) and responders (CBT‐I: 77.4–90.3%, WL: 19.4–24.1%) at post‐treatment and follow‐up, compared to the WL. Treatment was associated with high satisfaction, high adherence, low attrition, and few treatment‐impeding adverse events. Based on the medium to large effects of smartphone app‐delivered CBT‐I with telephone support, this trial highlights the potential of delivering CBT‐I exclusively through an app with therapist telephone support for high efficacy, satisfaction, and adherence.
Comparative Population Genomic Diversity and Differentiation in Trapdoor Spiders and Relatives (Araneae, Mygalomorphae)
Authors: Monjaraz‐Ruedas Rodrigo , Starrett James , Newton Lacie , Bond Jason E. , Hedin Marshal 
Published: October 2024

ABSTRACTAlthough patterns of population genomic variation are well‐studied in animals, there remains room for studies that focus on non‐model taxa with unique biologies. Here we characterise and attempt to explain such patterns in mygalomorph spiders, which are generally sedentary, often occur as spatially clustered demes and show remarkable longevity. Genome‐wide single nucleotide polymorphism (SNP) data were collected for 500 individuals across a phylogenetically representative sample of taxa. We inferred genetic populations within focal taxa using a phylogenetically informed clustering approach, and characterised patterns of diversity and differentiation within‐ and among these genetic populations, respectively. Using phylogenetic comparative methods we asked whether geographical range sizes and ecomorphological variables (behavioural niche and body size) significantly explain patterns of diversity and differentiation. Specifically, we predicted higher genetic diversity in genetic populations with larger geographical ranges, and in small‐bodied taxa. We also predicted greater genetic differentiation in small‐bodied taxa, and in burrowing taxa. We recovered several significant predictors of genetic diversity, but not genetic differentiation. However, we found generally high differentiation across genetic populations for all focal taxa, and a consistent signal for isolation‐by‐distance irrespective of behavioural niche or body size. We hypothesise that high population genetic structuring, likely reflecting combined dispersal limitation and microhabitat specificity, is a shared trait for all mygalomorphs. Few studies have found ubiquitous genetic structuring for an entire ancient and species‐rich animal clade.
Efficacy in myopia control—The impact of rebound
Authors: Bullimore Mark A. , Brennan Noel A. 
Published: October 2024

AbstractPurposeWhen myopia control treatment is discontinued, progression will increase, but does it revert to expected values based on the age and race of the child or does it accelerate further? The latter scenario is considered a rebound.MethodsA PubMed search was conducted with the words ‘rebound’ and ‘myopia control’, identifying further papers from reviews. Inclusion was limited to prospective studies with ≥6 months of treatment, ≥3 months of data following cessation and with axial length data, which allowed calculation of rebound. Nineteen studies were identified, comprising 24 treatment groups. In 10 studies, untreated control children were followed both throughout the treatment and cessation periods, allowing for a concurrent comparison group. In three studies, a control group was followed for 1 or 2 years and thereafter received the treatment under evaluation. Later, treatment ceased in the originally treated children. Finally, six studies were cross‐over designs. For these latter two study designs, initial axial elongation and myopia progression in the control group were extrapolated to the cessation period, accounting for annual slowing. Values from durations of <1 year were annualised.ResultsThe mean annualised rebound was +0.05 ± 0.10 mm and −0.09 ± 0.24 D for axial length and myopia progression, respectively, and these were correlated (r2 = 0.59, p < 0.001). Rebound was associated with 1‐year treatment efficacy (r2 = 0.43, p < 0.001). The mean annualised rebound with optical corrections was −0.01 ± 0.03 mm. Five of the six highest rebound values (≥0.14 mm) were from red light therapy and atropine studies. Rebound ranged from +0.03 to +0.14 mm for overnight orthokeratology.ConclusionsConsistent with previous statements, no evidence for rebound was found for myopia control spectacles and soft contact lenses. Future research should explore the influence of age and magnitude of treatment efficacy on rebound.
A scandalous presence in the courtroom: Indigenous immigrant interpreters and the politics of language ideologies in US courts
Authors: García María Luz 
Published: October 2024

AbstractThis article analyzes how the experiences and observations of Indigenous people from Latin America who work as legal interpreters reveal the ways that the position of court interpreter is racialized. The meaning of the norms of the “invisibility” and “neutrality” of the interpreter and the role of the interpreter as erasing barriers become points of contestation in the context of interpreting Indigenous languages of Latin America, revealing the ways that dominant norms and practices governing interpreting privilege a white speaker. Organizations of Indigenous interpreters articulate these experiences as a language rights issue of a transnational movement and point to the way that institutional claims to neutrality are symptomatic of a larger historical pattern of racism.
Identification of clerodane diterpene modifying cytochrome P450 (CYP728D26) in Salvia divinorum ‐ en route to psychotropic salvinorin A biosynthesis
Authors: Ngo Iris , Kumar Rahul , Li Liang , Kim Seon‐Won , Kwon Moonhyuk , Ro Dae‐Kyun 
Published: October 2024

AbstractSalvia divinorum is a hallucinogenic plant native to the Oaxaca in Mexico. The active ingredient for psychotropic effects in this plant is salvinorin A, a potent and highly selective κ‐opioid receptor agonist. Salvinorin A is distinct from other well‐known opioids, such as morphine and codeine, in that it is a non‐nitrogenous diterpenoid with no affinity for μ‐opioid receptor, the prime receptor of alkaloidal opioids. A terpene opioid that selectively targets a new opioid receptor (κ‐opioid receptor) can be instrumental in developing alternative analgesics. Elucidation of the salvinorin A biosynthetic pathway can help bio‐manufacture diverse semi‐synthetic derivatives of salvinorin A but, to date, only two enzymes in the Salvinorin A pathway have been identified. Here, we identify CYP728D26 that catalyzes a C18 oxygenation on crotonolide G, which bears a clerodane backbone. Biochemical identity of CYP728D26 was validated by in vivo reconstitution in yeast, 1H‐ and 13C‐NMR analyses of the purified product, and kinetic analysis of CYP728D26 with a Km value of 13.9 μM. Beyond the single oxygenation on C18, collision‐induced dissociation analysis suggested two additional oxygenations are catalyzed by CYP728D26 to form crotonoldie G acid, although this carboxylic acid form is a minor product. Its close homologue CYP728D25 exhibited a C1‐hydroxylation on the clerodane backbone in a reconstituted yeast system. However, CYP728D25 showed no activity in in vitro assays. This result implies that catalytic activities observed from overexpression systems should be interpreted cautiously. This work identified a new CYP catalyst and advanced our knowledge of salvinorin A biosynthesis.