bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and Optimization of Beta-Sitosterol Nanosuspension-Loaded In situ Gel by Using Box-Behnken Model for the Treatment of Prostate Cancer
Authors: Patil Vaibhav L. , Rane Bhushan R. , Mane Nikita P. , Jain Ashish S. 
Published: September 2024

Introduction:
Prostate cancer is the second most often occurring cancer in males and the
fourth most common cancer overall. Beta-sitosterol (β-Sit), the most prevalent plant phytosterol
found in several plant species, has been reported to have inhibitory effects against several malignancies.
Even though β-Sit has considerable potential, its therapeutic uses are limited due to its
poor aqueous solubility (<0.1 mg/ml), low bioavailability (0.41%), and poor absorption from GIT.
Nanosuspension is one of the most innovative approaches to address problems linked to low solubility
and poor absorption.

Methods:
In the present research work, β-Sit nanosuspension has been fabricated by nanoprecipitation-
ultrasonication, followed by high-pressure homogenization (Panda plus 2000) employing
HPMC E5 and poloxamer (188 and 407) as stabilizers, optimized using a Box-Behnken technique.
Subsequently, in situ nano gel was prepared by dispersion method using gellan gum as an ionsensitive
polymer by incorporating optimized nanosuspension.

Results:
The optimized nanosuspension was evaluated for various parameters and has been found
to have an average particle size (137 ± 5.07 nm), zeta potential (-24 ± 4.99), PDI (0.207), and improved
solubility up to 5 folds, being suitable for systemic absorption through the nasal route. The
optimized in situ gel was characterized and showed the desired viscosity, good spreadability, acceptable
gelation property, and sufficient mucoadhesive strength to adhere to nasal mucosa after
ionic interaction. The in vitro release of pure drug, nanosuspension, and the optimized gel was
compared, and optimized in situ gel showed a maximum release of 91.41 ± 1.32% up to 8 hours.

Conclusion:
It was concluded that the in situ nasal nanogel could be the best possible approach to
delivering β-Sit into systemic circulation for the treatment of prostate cancer.
Research on Auxiliary Effect of Lorentz Force for On-orbit Servicing of Spacecraft
Authors: Zhang Liang 
Published: September 2024

Background:
On-orbit servicing of spacecraft is mainly aimed at repairing failed spacecraft,
maintaining and upgrading normally operating spacecraft to extend their life in order to reduce
the increase of space debris and maintain the space environment.

Objective:
In performing on-orbit servicing, the spacecraft typically requires continuous control
force to hover for a long period of time in order to maintain a relatively stationary state towards the
target.

Methods:
Considering the limited amount of fuel carried, the Lorentz force is introduced into onorbit
servicing to assist spacecraft in hovering. In order to demonstrate the feasibility of using Lorentz
force as spacecraft thrust, many related patents have been provided.

Results:
Firstly, the velocity of the spacecraft's orbital motion and the variation of the geomagnetic
field were given, and the specific expression of the Lorentz force in the relative dynamics model of
the spacecraft was deduced. When studying the auxiliary effect of Lorentz force, a critical angle
was defined. The relation between the critical angle and the Lorentz force on the auxiliary effect of
spacecraft hovering was analyzed through numerical examples.

Conclusion:
Furthermore, based on the influence of the charge-to-mass ratio on the critical angle,
the variation law of the Lorentz force-assisted spacecraft hovering area with different charge-tomass
ratios was derived.
Automated External Bone Fixation Robot Design and Orthopedic Analysis
Authors: Shi Zhi , Su Peng , Zhao Wei , Xie Shihui , Liu Lin , Zhang Li 
Published: September 2024

Background:
Bone external fixation technology is an important therapeutic approach for
limb correction, primarily involving a class of external fixation correction mechanisms. It has
achieved good results in limb lengthening and correcting deformities to restore limb function. In
clinical practice, existing correction mechanisms face challenges such as high resistance between
components, complex installation procedures, and high precision requirements for installation, requiring
manual adjustment by physicians, which limits precise control and quantification of correction
parameters.

Objective:
To address these issues, an automated correction bone external fixation robot was designed
based on traditional Ilizarov external fixation devices(TIEFD).

Methods:
By increasing the number of unidirectional hinge connections, the robot can effectively
reduce motion resistance. Subsequently, the robot was combined with the tibia for correction motion
simulation, obtaining the motion parameters θ of the deformed bones during the correction
process based on the trajectory of the tibia's point mass. Finally, correction motion experiments and
finite element analysis(FEA) were conducted on the robot combined with a control system.

Results:
The results showed that the robot could precisely control correction parameters, with the
error range for rotational correction not exceeding 0.5 radians and the error range for traction correction
not exceeding 0.2 mm. FAE, based on corrective force data, concluded that compared to
(TIEFD), the robot could reduce bone stress by 16 MPa during the correction process.

Conclusion:
The robot effectively reduces patient discomfort, this provides a reliable theoretical
basis for bone external fixation technology and holds positive significance for the treatment of skeletal
deformities.
Rapid Identification of Lactobacillus acidophilus and Bifidobacterium by a 16S rRNA PCR Method
Authors: Hazra Amit , Saha Pijush K , Bhattacharjee Dipanwita , Bhattacharyya Barun K. 
Published: September 2024

Background:
Probiotics are live microorganisms that, when administered, have beneficial
effects on human health. Hence, various probiotic organisms belonging to the genera Lactobacillus
and Bifidobacterium are being increasingly used in food and pharmaceutical products. For
regulatory compliance, simple and reliable analytical methods are required for selective enumeration
of different probiotic organisms present in food and pharmaceutical formulations.

Objective:
This study aimed to establish a rapid PCR-based method for the identification and differentiation
of Lactobacillus acidophilus and Bifidobacterium strains.

Methods:
Species-specific and genus-specific primers for Lactobacillus and Bifidobacterium were
designed based on their 16S rRNA gene sequence. Genomic DNA of different Lactobacillus and
Bifidobacterium strains were subjected to PCR with annealing temperature specific for respective
primer pairs.

Results:
Lactobacillus acidophilus primers gave positive PCR results only with Lactobacillus acidophilus
strains and not with other Lactobacillus species, whereas Bifidobacterium genus-specific
primers gave positive PCR results with most of the Bifidobacterium strains.

Conclusion:
The three species-specific L. acidophilus primer pairs and three genus-specific primer
pairs of Bifidobacterium used in this study could easily identify and differentiate Lactobacillus acidophilus
and Bifidobacterium with high specificity.
ANALISIS STRATEGI PENGHIMPUNAN DANA INFAQ MELALUI PROGRAM SAFARI BERKISAH DI YAYASAN DANA SOSIAL AL FALAH MALANG
Authors: Puspita Sari Anggie , Anggraini Ika Khusnia 
Published: September 2024

Many infaq management institutions such as Baznas and LAZ have been established. These institutions certainly need a strategy in collecting for the sustainability of the institution and realizing its distribution program. This study aims to determine the implementation of the Safari Berkisah program as a method of collecting infaq at YDSF Malang, and the impact of the Safari Berkisah program on YDSF Malang and stakeholders. The gap between this research and the research that has been done lies in the object of research where in previous studies no one has made Safari Berkisah as the object of research. The method used in this research is a qualitative method with a case study approach. From this research it is known that the implementation of the Safari Berkisah program at YDSF Malang is in accordance with the stages of fundraising strategy and the program has a positive impact on YDSF Malang and stakeholders. The results of this study are expected to be input for the Al Falah Social Fund Foundation Malang regarding the Safari Berkisah method as one of its collection methods, and can be taken into consideration for zakat, infaq, and alms management institutions in carrying out collection activities, especially through Safari Berkisah activities.
Wychowawcza obecność polskich salezjanów w Wilnie 1924-1945. Zarys problematyki
Authors: Pietrzykowski Jan 
Published: September 2024

Salezjanie przybyli do Wilna w 1924 r. i przejęli do obsługi koedukacyjne placówki opiekuńcze prowadzone przez ks. prałata Karola Lubiańca. Pierwszy dyrektor domu zakonnego, ks. dr Wojciech Balawajder zlikwidował koedukacyjny charakter tych dzieł dobroczynnych. Salezjanie z chłopcami pozostali przy ul. Dobrej Rady i dodatkowo obsługiwali kościół Opatrzności Bożej. Dziewczęta umieszczono przy ul. Stefańskiej w pobliżu dworca kolejowego. W 1928 r. salezjanom oddano do użytku kościół św. Stefana, przy którym powstał osobny dom zakonny. Księża i klerycy prowadzili oratorium, uczyli religii w szkołach, pełnili posługę w więzieniach, studiowali na Uniwersytecie Stefana Batorego. W czasie drugiej wojny światowej zakonnicy prowadzili ograniczoną działalność duszpasterską i angażowali się w nauczanie na tajnych kompletach. Podczas okupacji litewskiej, sowieckiej i niemieckiej salezjanie zostali usunięci z placówki przy ul. Dobrej Rady i byli internowali w domach salezjanów litewskich. Po drugiej wojnie światowej większość polskich salezjanów wróciła z Wilna i z Wileńszczyzny do Polski.
Wastewater Monitoring During the COVID-19 Pandemic in the Veneto Region, Italy: Longitudinal Observational Study
Authors: Ocagli Honoria , Zambito Marco , Da Re Filippo , Groppi Vanessa , Zampini Marco , Terrini Alessia , Rigoli Franco , Amoruso Irene , Baldovin Tatjana , Baldo Vincenzo , Russo Francesca , Gregori Dario 
Published: September 2024

Abstract

Background
As the COVID-19 pandemic has affected populations around the world, there has been substantial interest in wastewater-based epidemiology (WBE) as a tool to monitor the spread of SARS-CoV-2. This study investigates the use of WBE to anticipate COVID-19 trends by analyzing the correlation between viral RNA concentrations in wastewater and reported COVID-19 cases in the Veneto region of Italy.

Objective
We aimed to evaluate the effectiveness of the cumulative sum (CUSUM) control chart method in detecting changes in SARS-CoV-2 concentrations in wastewater and its potential as an early warning system for COVID-19 outbreaks. Additionally, we aimed to validate these findings over different time periods to ensure robustness.

Methods
This study analyzed the temporal correlation between SARS-CoV-2 RNA concentrations in wastewater and COVID-19 clinical outcomes, including confirmed cases, hospitalizations, and intensive care unit (ICU) admissions, from October 2021 to August 2022 in the Veneto region, Italy. Wastewater samples were collected weekly from 10 wastewater treatment plants and analyzed using a reverse transcription–quantitative polymerase chain reaction. The CUSUM method was used to detect significant shifts in the data, with an initial analysis conducted from October 2021 to February 2022, followed by validation in a second period from February 2022 to August 2022.

Results
The study found that peaks in SARS-CoV-2 RNA concentrations in wastewater consistently preceded peaks in reported COVID-19 cases by 5.2 days. Hospitalizations followed with a delay of 4.25 days, while ICU admissions exhibited a lead time of approximately 6 days. Notably, certain health care districts exhibited stronger correlations, with notable values in wastewater anticipating ICU admissions by an average of 13.5 and 9.5 days in 2 specific districts. The CUSUM charts effectively identified early changes in viral load, indicating potential outbreaks before clinical cases increased. Validation during the second period confirmed the consistency of these findings, reinforcing the robustness of the CUSUM method in this context.

Conclusions
WBE, combined with the CUSUM method, offers valuable insight into the level of COVID-19 outbreaks in a community, including asymptomatic cases, thus acting as a precious early warning tool for infectious disease outbreaks with pandemic potential.
Authentic Leadership and Team Performance: Exploring the Mediating Role of Dynamic Adaptive Capability
Authors: Sumarmi Saptaningsih , Tjahjono Heru Kurnianto , Qamari Ika Nurul , Shaikh Mohsin 
Published: September 2024

Introduction/Main Objectives: This research explores Dynamic Adaptive Capability to achieve Team Performance in higher education institutions, focusing on the challenges posed by a rapidly changing global environment. The study emphasizes the importance of dynamic adaptability as a mediating variable, connecting Authentic Leadership and Justice Climate as key elements influencing Team Performance. Background Problems: The main question of this research is whether Authentic Leadership improves Team Performance through Dynamic Adaptive Capability. The urgency of this research in Indonesia's higher education context is critical, considering that the ever-changing global environment demands rapid and effective adaptation to remain competitive and relevant. Novelty: Empirical evidence explaining how Authentic Leadership can improve Team Performance in Indonesian higher education still needs to be explored. Therefore, research that finds this mechanism is still required and adds Dynamic Adaptive Capability as a mediator. Research Methods: This research collected a survey of the Head of the Study Program as a team representative, used purposive sampling, and utilized AMOS SEM analysis to test the hypothesis. Finding/Results: The research shows that Authentic Leadership positively impacts Dynamic Adaptive Capability and Team Performance. Meanwhile, Justice Climate has no relationship with Team Performance but positively impacts Dynamic Adaptive Capability. Dynamic Adaptive Capability positively mediates Authentic Leadership and Team Performance while negatively mediating Justice Climate and Team Performance. Conclusion: In addition to supporting several hypotheses, this research also highlights the complex and diverse nature of these relationships, prompting recommendations for strategic planning and further investigation to deepen our understanding of the dynamics in organizational environments.
La separación de poderes del Estado frente al hiperpresidencialismo: nuevo rol del gobierno salvadoreño
Authors: Sánchez de Rodríguez Odaly Lissette 
Published: September 2024

El artículo se basa en el estudio de la importancia de la separación de poderes y los controles interorgánicos establecidos en la Constitución de la República de El Salvador para el manejo del Estado, frente a figuras como el hiperpresidencialismo, que rompen estos controles por el manejo unipersonal de las decisiones. Para presentar este estudio, se inicia con un esbozo de la corrupción en el Estado salvadoreño que da el punto de partida para el desencanto de los partidos tradicionales y el surgimiento de figuras presidenciales populares como es el caso del presidente Nayib Bukele, siguiendo con el estudio de los controles de los poderes del Estado como herramientas que limitan el poder y que son necesarias para la discusión de las decisiones y el buen manejo de los recursos, sin dejar a un lado la necesidad de evaluar cómo y con qué fines se utilicen dichas herramientas. También, se analiza la otra arista a los controles, que es la libre gestión de las decisiones gubernamentales, al tener un control pleno del Estado, donde una Asamblea Legislativa es anuente y no ejerce la función de debate. Para finalizar, se presenta un análisis de la figura del hiperpresidencialismo en el contexto salvadoreño y los retos a futuro del contexto político actual.
Penerapan Bimbingan dan Konseling dengan Teknik Psikodrama dalam Lingkup Pendidikan
Authors: Amanah Siti Nuraida , Silva Neng , Muna Naeila Rifatil 
Published: September 2024

Rendahnya kualitas pendidikan diiringi oleh beberapa faktor, seperti halnya permasalahan pembelajaran, rendahnya mutu pendidikan, dan rendahnya prestasi belajar siswa. Bimbingan konseling hadir sebagai salah satu sarana dalam meningkatkan kualitas peserta didik. Salah satu teknik dalam bimbingan dan konseling adalah psikodrama. Tujuan penelitian ini yakni untuk memahami peranan penerapan psikodrama dalam lingkup pendidikan sebagai upaya peningkatan kualitas peserta didik. Penelitian ini menggunakan pendekatan kualitatif dengan studi literatur. Psikodrama merupakan suatu metode yang menggabungkan antara drama dan psikologi dalam membantu individu dalam mengembangkan potensi, serta memecahkan permasalahan sosial dan emosional. Psikodrama telah banyak diterapkan dalam dunia pendidikan. Adapun peranan psikodrama yakni meningkatkan kecerdasaan emosional peserta didik, sarana peningkatan self disclosure (keterbukaan diri), membangun kemandirian belajar, membangun self concept (konsep diri), dan sebagai sarana pelatihan guru dalam meningkatkan pembelajaran yang kreatif.
Peranan Self-Efficacy dan Social Support terhadap Career Indecision pada Siswa SMA di Sekolah X
Authors: Satriana Dwi Puspita , Sahrani Riana 
Published: September 2024

Ketidakmampuan individu dalam menentukan pilihan pendidikan dan pekerjaan sesuai keinginannya merupakan masalah yang penting untuk diteliti, namun sedikit yang meneliti peran self-efficacy dan social support terhadap career indecision. Desain penelitian yang digunakan adalah kuantitatif korelasional. Sampel penelitian berjumlah 172 siswa kelas XI di Sekolah Menengah Atas yang dipilih menggunakan teknik cluster random sampling. Pengumpulan data menggunakan Career indecision Scale (CIS), New General Self- Efficacy Scale (NGSE), dan The Multidimentional Scale of Perceived Social support (MSPSS). Data dianalisis menggunakan teknik regresi berganda dengan bantuan SPSS 20.00. Hasil penelitian menemukan bahwa adanya hubungan simultan antara self-efficacy dan social support dengan career indecision (p value = 0,001, p < 0,05). Self-efficacy berperan negatif terhadap career indecision (r2= -0.162, p< 0.05) dan berkontribusi sebesar 16.2%. Sedangkan social support berperan negatif terhadap career indecision dan berkontribusi sebesar 17,7%. (r2=0.177, p< 0.05) Dengan demikian dapat disimpulkan bahwa self-efficacy dan social support berperan terhadap career indecision. Penelitian ini mengindikasikan pentingnya program career counseling yang terintegrasi dengan psikoedukasi untuk keluarga dan sekolah untuk memperkuat kemampuan siswa mengambil keputusan karir.
Inkluderande och tvärvetenskaplig utbildningspraktik, när biologi och genusvetenskap möts
Authors: Günter Katerina Pia , Gullberg Annica , Ahnesjö Ingrid 
Published: September 2024

Det värdefulla med ämnesöverskridande utbildning får mer och mer stöd i didaktisk och pedagogisk forskning. Tvärdisciplinär undervisning uppmuntras, men det finns ännu få exempel på hur man pedagogiskt kan utforma undervisningen i praktiken. Vi ger här exempel på hur man i en tvärvetenskaplig utbildningspraktik kan arbeta med inkludering, interaktion och lagarbete för att utveckla tvärvetenskaplig kommunikation och samarbete. Våra exempel kommer från en fristående grundkurs där genusvetenskap och biologi befruktar varandra ämnesmässigt och där trygga undervisningsmiljöer med inkluderande diskussioner utvecklar studenterna till att få nya och förändrade perspektiv. Vi reflekterar över praktik och upplägg som kan användas i en mångfald av undervisningssammanhang där kommunikation och inkludering är bärande för tvärvetenskapligt lärande.
ENGLISH ABSTRACT
Inclusive Interdisciplinary Teaching Practices when Embracing Biology and Gender Studies
Values of interdisciplinary education is increasingly supported by didactical and pedagogical research. While we are encouraged to teach interdisciplinarily, there are only few examples of how to shape such teaching practices pedagogically. We here provide examples and structures of ways to teach inclusively, interactively and in teams to develop an interdisciplinary dialogue, transgressing monodisciplinary teaching. Our examples derive from an independent basic undergraduate course where gender studies and biology embrace each other as disciplines, and where students develop new perspectives through inclusive discussions in safe teaching settings. We reflect over practices that are useful in a diversity of educational contexts, where discussions and dialogues form the basis for inclusion and interdisciplinary learning.
Monitoring Mining Impact for Geosites Using Time Series NDVI and Run-off in the Eastern Part of Southern Java Mountains, Indonesia
Authors: Kurnianto Fahmi Arif , Nurdin Elan Artono , Pangastuti Era Iswara , Bella Syintia 
Published: September 2024

Several geosites in the Eastern Part of the Southern Mountains of Java which are currently being mined are important geosites because they have recorded tectonic processes in the tertiary period. However, mining activities without environmental monitoring could be lead loss of rock outcrops and alteration of mineralscontained in the geosite. This study aims to monitor the vegetation index and run off in karst geosites and gold mined hills. We used Sentinel 2A Imagery on the Google Earth Engine (GEE) to get the vegetation index (NDVI) and run off values temporally. The Sentinel 2A data acquisition pro-cess in both 2018 and 2022 was carried out on the Google Earth Engine with specific steps consisting import data from cloud collection, cloud masking, and customing date acquistion. The results show that there has been a decrease in the vegetation index in the period 2018-2022 which is indicated by the decrease in the vegetation index value in the mined area. Another impact found is that there has been an increase in the run-off value in 2022 in both the Karst Puger Hills and the Tumpang Pitu Hills. The NDVI pattern on mined geosites has also changed significantly due to increasingly intense mining activities. The NDVI fluctuation pattern in the Karst Hills in 2018-2020 ranges from 0.41 to 0.74, while in 2021-2022 the fluctuation pattern is only in the range 0.05 to 0.4, respectively. The NDVI fluctuation pattern in the Tumpang Pitu Gold Hills in 2018-2019 is in the range 0.6 to 0.8, while in 2020-2022 it is in the range 0.38 to 0.52, respectively. Google Earth Engine is able to map the vegeta-tion index more efficiently by using a time series approach. These advancement is different compare to previous studies, where our study shows rapid acquisition during pre-processing, performing NDVI with rapid temporal analysis, and shows numerous degraded land in southern java mountains. There-fore, it can be concluded that there has been a decrease in the vegetation index and an increase in run off which can threaten the rock outcrop on the geosite. Furthermore, this study suggest that GEE should be considered as a main tool to identified degraded land, particularly for geosite conservation.