bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral-Only Linezolid-Rifampin Is Highly Effective Compared with Other Antibiotics for Periprosthetic Joint Infection
Authors: Thompson John M. , Saini Vikram , Ashbaugh Alyssa G. , Miller Robert J. , Ordonez Alvaro A. , Ortines Roger V. , Wang Yu , Sterling Robert S. , Jain Sanjay K. , Miller Lloyd S. 
Published: April 2017

Background:
The medical treatment of periprosthetic joint infection (PJI) involves prolonged systemic antibiotic courses, often with suboptimal clinical outcomes including increased morbidity and health-care costs. Oral and intravenous monotherapies and combination antibiotic regimens were evaluated in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) PJI.

Methods:
Oral linezolid with or without oral rifampin, intravenous vancomycin with oral rifampin, intravenous daptomycin or ceftaroline with or without oral rifampin, oral doxycycline, or sham treatment were administered at human-exposure doses for 6 weeks in a mouse model of PJI. Bacterial burden was assessed by in vivo bioluminescent imaging and ex vivo counting of colony-forming units (CFUs), and reactive bone changes were evaluated with radiographs and micro-computed tomography (μCT) imaging.

Results:
Oral-only linezolid-rifampin and all intravenous antibiotic-rifampin combinations resulted in no recoverable bacteria and minimized reactive bone changes. Although oral linezolid was the most effective monotherapy, all oral and intravenous antibiotic monotherapies failed to clear infection or prevent reactive bone changes.

Conclusions:
Combination antibiotic-rifampin regimens, including oral-only linezolid-rifampin and the newer ceftaroline-rifampin combinations, were highly effective and more efficacious than monotherapies when used against a preclinical MRSA PJI.

Clinical Relevance:
This study provides important preclinical evidence to better optimize future antibiotic therapy against PJIs. In particular, the oral-only linezolid-rifampin option might reduce venous access complications and health-care costs.
Development and Validation of the Short Multidimensional Well-Being Questionnaire (SMWQ)
Authors: Bigot Lucile , Garncarzyk Catherine , Gauthier Antoine , Quarck Gaelle , Dosseville Fabrice 
Published: April 2017

Purpose:Psychological well-being and health are closely linked at older ages. It is widely recognized that adapted regular physical exercise improves drastically both the physical and emotional well-being and allows older adults to stay healthy longer, with a better quality of life. In the framework of a European project (MOTION) to increase the life expectancy, independence and quality of life of older adults, the aim of the current research was to develop and validate a brief, multi-faceted, self-report measure of well-being in older adults.Method:The aim of Study 1 was to establish the factor structure of the newly developed measure using Exploratory Factor Analysis (EFA). The aim of Study 2 was to replicate the measure's factor structure using Confirmatory Factor Analysis (CFA), and to evaluate test-retest reliability and convergent validity.Results:Analyses allowed generating a model of well-being comprising four dimensions: Perceived physical value, self-esteem and self-efficacy, socialization, and emotional reactions.Conclusion:The findings suggest that the SMWQ is appropriate for use with older adults and can help researchers and health professionals to assess the effects of APA programs.
Hubungan Anemia Dan Usia pada Ibu Hamil Dengan Kejadian Abortus Inkomplit Di RSUD Dr. Achmad Mochtar Bukittinggi tahun 2015.
Authors: Khadijah Siti 
Published: April 2017

<p>Abortus Inkomplit merupakan salah satu abortus yang sering terjadi pada kehamilan trimester I dan II di RSUD Dr. Achmad Mochtar Bukittinggi. Sedangkan dari 145 kasus abortus terdapat (77,24%) orang ibu yang mengalami abortus inkomplit. Tujuan penelitian ini untuk mengetahui hubungan antara anemia dan usia ibu hamil dengan kejadian abortus Inkomplit di RSUD Dr. Achmad Muchtar Bukittinggi Tahun 2015. Jenis penelitian <em>Deskriptif</em> <em>analitik</em> dengan desain kasus control <em>(case control) </em>yang dilaksanakan di RSUD Dr Achmad Mochtar Bukittinggi pada tanggal 6 Oktober 2015. Populasi dalam penelitian ini seluruh ibu hamil trimester I dan II di RSUD Dr. Achmad Mochtar Bukittinggi Tahun 2015, dengan metode pengambilan sampel <em>Simple Random Sampling</em> yang berjumlah 112 orang. Pengumpulan data mengunakan data sekunder dengan langkah pengolahan data terdiri dari <em>editing,coding,entry,tabulating</em>. Analisa univariat dilakukan dengan statistik deskriptif berupa distribusi frekuensi dan persentase, sedangkan analisis bivariat dilakukan dengan uji <em>chi-square</em>. Hasil penelitian didapatkan, reproduksi tidak sehat 61 (74,4%), yang tidak anemia 71 (86,6%) dan yang mengalami abortus inkomplit sebanyak 41 (50%). Uji Chi Square ada hubungan bermakna antara usia dengan kejadian abortus inkomplit P value=0,002 (P&lt;0,005), dan ada hubungan yang tidak bermakna antara anemia dengan kejadian abortus inkomplit P value=0,052 (P&lt;0,005). Dari data di atas dapat disimpulkan bahwa terdapat hubungan antara usia dengan kejadian abotus inkomplit dan tidak terdapat hubungan antara anemia dengan kejadian abortus inkomplit. Diharapkan kepada petugas kesehatan di RSUD Dr.Achmad Mochtar Bukittinggi agar meningkatkan pelayanan dan mengadakan penyuluhan dan pembinaan kepada ibu hamil terutama pada ibu hamil trimester 1 dan 2 dan di utamakan kepada ibu yang memiliki usia &lt;19 dan &gt;35 tahun.</p>
Amalú perdió un botón. De instrumento de juego a recurso para estimular y trabajar la percepción visual
Authors: Villalobos Gamboa Daniel 
Published: April 2017

En este artículo se describe cómo las teorías de especialistas en lúdica, percepción visual y aprendizaje, fortalecen un instrumento doméstico de juego y lo transforman en una herramienta para estimular a las niñas y los niños que hoy crecen en una sociedad generosamente visual y así ayudarles a agudizar sus sentidos con el fin de que realicen una mejor lectura del mundo.
Evaluación de modelos de diseño instruccional: una revisión de literatura
Authors: Umaña Mata Ana Cristina 
Published: April 2017

En este artículo se presenta la reseña de literatura, efectuada en relación con el tema de la evaluación de modelos de diseño instruccional. El trabajo surge previo a la realización de una investigación, cuyo objetivo fue “evaluar el modelo de diseño de cursos de la UNED, con el fin de identificar los componentes que generan retraso en el proceso de producción de materiales instruccionales y proponer modificaciones al modelo” (Umaña, 2012, p. 6). En la investigación bibliográfica realizada, se concluye que la evaluación de los modelos es un interés reciente, dado que, generalmente han sido validados en su puesta en práctica. Sin embargo, posterior a su implementación, el componente evaluativo es dejado de lado; lo cual limita las posibilidades de realizar mejoras y cambios, antes de que el modelo entre en un proceso de caducidad.Se persigue, por tanto, un acercamiento teórico en relación con el tema y la discusión de aspectos fundamentales a considerar en la actualidad; teniendo en cuenta el creciente auge de los procesos de autoevaluación y acreditación educativa en las instituciones de educación superior.
Propuesta para el desarrollo de una aplicación para la gestión administrativa en la UNED, Costa Rica
Authors: Bejarano Salazar Ana Gabriela Gabriela , Berrocal Carvajal Viviana , Salas Campos Ileana , Valerio Álvarez Cinthya 
Published: April 2017

El artículo presenta los resultados de la investigación sobre los servicios que debe brindar la aplicación para dispositivos móviles que facilite la gestión administrativa de profesores y estudiantes de la Universidad Estatal a Distancia (UNED) de Costa Rica. La primera fase de la metodología consistió en una revisión de las aplicaciones institucionales para dispositivos móviles que utilizan algunas universidades nacionales e internacionales. Los resultados obtenidos mostraron que 100% poseen el servicio de noticias y el mapa del campus universitario, 83,3% ofrecen los horarios de clases o tutorías y el acceso a redes sociales, 66,7% la opción para ingresar a la biblioteca, la lista de eventos, la información de carreas y las plataformas en línea. Luego, en una segunda fase, se aplicó un cuestionario auto administrado a estudiantes y profesores de la UNED, con el fin de conocer la tenencia de dispositivos móviles y las preferencias de servicios que podría brindar una aplicación para móviles en la UNED. Los resultados indicaron que 75% de los estudiantes que tienen teléfono celular, acceden a Internet a través de ellos, 30% manifestó tener tabletas y 72% computadoras portátiles. Tanto profesores como estudiantes señalaron que las preferencias de servicios accesibles desde dispositivos móviles son, en orden de prioridad: matrícula, acceso a Blackboard y Moodle, información de carreras, horario de tutorías y la posibilidad de enviar correos. Investigaciones posteriores podrían medir el impacto de la implementación de una aplicación institucional para dispositivos móviles en la UNED.
Percepción docente del rendimiento académico de los estudiantes universitarios de la USAC Guatemala que trabajan y estudian
Authors: García Caal Edwin Rolando 
Published: April 2017

Esta investigación exploró la percepción de los docentes en relación con el rendimiento académico de estudiantes universitarios que además son trabajadores asalariados. Los docentes entrevistados pertenecen a la Facultad de Ciencias Económicas, campus central de la Universidad de San Carlos de Guatemala (USAC). Según se encontró en la literatura, para algunos autores la combinación “trabajar y estudiar en la universidad” tiene un efecto positivo en el rendimiento académico, así lo explican Caballero (2006) y Lillydahl (1990); en tanto que otros autores concluyen que dicha relación es negativa; tal como lo plantean Tyler (2003) y Paul (1982). Para validar una de estas dos posiciones, metodológicamente se realizaron las entrevistas a los docentes, y posteriormente se efectuaron observaciones estructuradas para profundizar en el contexto de las variables señaladas en las entrevistas. La mayoría de los entrevistados respondió que un trabajo asalariado es una de las causas que influencian negativamente el rendimiento académico universitario. Sin embargo, refirieron que ese efecto va precedido de “una baja calidad” de la educación preuniversitaria y dificultades en el acceso al campus. Se propone contrarrestar dicho efecto ampliando la capacidad docente y como solución no académica mejorar el acceso físico al campus universitario; al mismo tiempo se descubrió la necesidad de lograr una mejor definición del rol del estudiante universitario, porque los docentes pretenden que la universidad se adapte a las capacidades de los estudiantes y no al contrario.
Diabetes, Associated Clinical Spectrum, Long-term Prognosis, and Genotype/Phenotype Correlations in 201 Adult Patients With Hepatocyte Nuclear Factor 1B (HNF1B) Molecular Defects
Authors: Dubois-Laforgue Danièle , Cornu Erika , Saint-Martin Cécile , Coste Joël , Bellanné-Chantelot Christine , Timsit José ,   for the Monogenic Diabetes Study Group of the Société Francophone du Diabète
Published: April 2017

OBJECTIVE
Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and kidney abnormalities. The HNF1B syndrome is related to HNF1B mutations or to a 17q12 deletion spanning 15 genes, including HNF1B. Here, we described HNF1B-related diabetes and associated phenotypes and assessed genotype/phenotype correlations at diagnosis and in the long-term.

RESEARCH DESIGN AND METHODS
This multicenter retrospective cohort study included 201 patients, aged 18 years or older at follow-up, with HNF1B mutations (n = 101) or deletion (n = 100).

RESULTS
Diabetes was present in 159 patients. At diagnosis, clinical symptoms of diabetes were present in 67 of 144 patients and HNF1B renal disease in 64 of 102. Although responsiveness to sulfonylureas/repaglinide was observed in 29 of the 51 tested, 111 of 140 patients (79%) were treated with insulin at follow-up. Diabetic retinopathy and/or neuropathy were present in 46 of 114 patients. Renal cysts were present in 122 of 166 patients, chronic kidney disease stages 3–4 (CKD3–4) in 75 of 169 (44%), and end-stage renal disease (ESRD) in 36 of 169 (21%). Compared with the patients with mutations, those with HNF1B deletion less often had CKD3–4/ESRD at diagnosis (11 of 43 vs. 27 of 35, P &lt; 10−4) and in the long term (40 of 78 vs. 71 of 91, P = 0.0003). They were leaner and more frequently treated with insulin.

CONCLUSIONS
In patients with HNF1B syndrome, diabetes complications, cardiovascular risk factors, CKD3–4, and ESRD are highly prevalent. At diabetes diagnosis, the presence of morphological and/or functional kidney disease may help etiological diagnosis. Genotype/phenotype correlations may have implications for the care and the prognosis of these patients.
Temporal and Spatial Variation of Broadcasted Vocalizations Does not Reduce Lion Panthera leo Habituation
Authors: Belant Jerrold L. , Bled Florent , Mwampeta Stanslaus B. , Mkasanga Imani J. , Wilton Clay M. , Fyumagwa Robert 
Published: April 2017

Estimating abundance of large carnivores is often challenging, yet important for their effective conservation. Attracting lions Panthera leo for visual enumeration using broadcasted vocalizations (i.e. call‐ins) is commonly used to estimate their abundance. However, call‐ins are typically not repeated at sites because of habituation. We evaluated lion response to repeated call‐ins varying temporally (1 or 2 weeks) and spatially (1 or 2 km) in Serengeti National Park (SNP), Tanzania, during February—April 2016. We established 30 call‐in sites: at 10 sites we used lion and spotted hyena Crocuta crocuta calls while alternating prey distress calls across five consecutive weeks; at 10 sites we alternated calls but conducted call‐ins once every two weeks; and at 10 sites we alternated calls weekly for five weeks but moved among three locations separated by 1 or 2 km each week. We used N‐mixture models to assess which sampling design would elicit greater lion detections across sessions and to estimate overall abundance. Lions habituated to broadcasted calls within each sampling design, with detectability point estimates overall declining across sessions. Estimated lion abundance at these 30 sites was 198 (95% credible interval = 186–214). Altering time interval and location of call‐ins was ineffective at reducing lion habituation. However, altering calls across sessions appeared to reduce lion habituation when compared to a previous survey in SNP that used the same calls across sessions. We recommend that call‐in surveys using repeated broadcasts are conducted at the same sites across sessions and use different calls to improve lion response and consequently, estimates of abundance.
Development of an Energy-Efficient Burner for Heat Treatment Furnaces with a Reducing Gas Atmosphere*
Authors: Schmitz N. , Schwotzer C. , Pfeifer H. , Schneider J. , Cresci E. , Wünning J. G. 
Published: April 2017

Abstract
One of the main reasons for metal loss of semi-finished metal products during heating in reheating and heat treatment furnaces is scale formation. In the presented project a burner is developed which produces a low oxidizing / reducing atmosphere in the furnace. The concept is realized by a recuperative burner, which generates a reducing furnace atmosphere due to fuel rich combustion of natural gas and air. The complete combustion of the furnace atmosphere is ensured by the injection of additional air and takes places in an open radiant tube resulting in a high energy efficiency. In this paper numerical and experimental results are presented and discussed. The numerical results showed the huge impact of the secondary air swirl on the post-combustion in the annular gap which is formed between the open radiant tube and the burner. Mixing phenomena in the annular gap results in a nearly complete post-combustion at low and high swirl angles of the additional combustion air (ω = 0°, ω = 90°). Instead of that, at a swirl angle of ω = 45° the entire reaction from CO to CO2 was not ensured within the boundaries of the numerical model. The quality of the post-combustion was experimentally evaluated by measuring the CO-emissions in the off-gas channel. These were lower than 50 mg/m3 in a wide range of operation. The NOx-emissions are lower than 121 mg/m3 at all tested cases.
Einfluss der Temperatur und des Vergütungszustands auf die Wärmeleitfähigkeit von Warmarbeitsstählen für das Presshärten*
Authors: Hafenstein S. , Werner E. , Wilzer J. , Theisen W. , Weber S. , Sunderkötter C. , Bachmann M. 
Published: April 2017

Kurzfassung
Die erreichbare Bauteilfestigkeit ist beim Presshärten von der Einstellung einer möglichst raschen Wärmeabfuhr abhängig. Diese Studie untersucht den Einfluss der Werkstoffzusammensetzung und der Wärmebehandlung auf die Wärmeleitfähigkeit von zwei unterschiedlichen Warmarbeitsstählen im Temperaturbereich zwischen 293 K und 773 K. Die Temperaturleitfähigkeit wurde mithilfe der dynamischen Messmethode indirekt gemessen. Die dargestellten Ergebnisse zeigen, dass die Wärmeleitfähigkeit eines Warmarbeitsstahls mit zunehmendem Legierungsgehalt abnimmt. In dem für die Anwendung des Presshärtens relevanten Temperaturbereich unterhalb von 473 K steigt die Wärmeleitfähigkeit ungeachtet des jeweiligen Wärmebehandlungszustands bei den zwei untersuchten Warmarbeitsstählen mit der Untersuchungstemperatur an. Für Anwendungen, bei denen die Werkzeuge Temperaturen oberhalb von 473 K ausgesetzt werden, ist zu beachten, dass die Wärmeleitfähigkeit mit weiterer Erhöhung der Temperatur abfällt.
Palliative Care in the Process of Human Terminality: Integrative review
Authors: Costa Emilie De Oliveira , Batista Patrícia Serpa de Souza , Silva Jessyka Cibelly Minervina da Costa , Lima Débora Rodrigues Alves de , Farias Priscilla De Freitas , Bezerra Ana Hévila Marinho , Oliveira Lúcia Raiza Feitosa Alves de , Costa Thaíza Ferreira da , Dias Kalina Coeli Costa de Oliveira 
Published: April 2017

Objectives: to characterize the scientific production on Palliative Care in the process of human terminality in the Health field, from 2007 to 2016.
Methods: integrative review of the literature conducted in September and October 2016, available from the Virtual Health Library through the electronic databases: SciELO, LILACS and BDENF. The guiding question was: What is the characterization of the scientific production on Palliative Care in the process of the human terminality disseminated in online journals in the Health field, from 2007 to 2016? The study sample consisted of 27 publications related to the investigated topic, using the descriptors "palliative care and terminality". The analyzed data were grouped and presented in figures.
Results: from the selected publications, two thematic categories emerged: Palliative care to the terminal patient with an emphasis on humanization and Assistance to the terminal patient in palliative care.
Conclusion: this review verified that the production is incipient, and that technical and humanized actions guide the practice of palliative care.
Tycho-Gaia Astrometric Solution Parallaxes and Proper Motions for Five Galactic Globular Clusters
Authors: Watkins Laura L. , van der Marel Roeland P. 
Published: April 2017

Abstract
We present a pilot study of Galactic globular cluster (GC) proper motion (PM) determinations using Gaia data. We search for GC stars in the Tycho-Gaia Astrometric Solution (TGAS) catalog from Gaia Data Release 1 (DR1), and identify five members of NGC 104 (47 Tucanae), one member of NGC 5272 (M3), five members of NGC 6121 (M4), seven members of NGC 6397, and two members of NGC 6656 (M22). By taking a weighted average of member stars, fully accounting for the correlations between parameters, we estimate the parallax (and, hence, distance) and PM of the GCs. This provides a homogeneous PM study of multiple GCs based on an astrometric catalog with small and well-controlled systematic errors and yields random PM errors similar to existing measurements. Detailed comparison to the available Hubble Space Telescope (HST) measurements generally shows excellent agreement, validating the astrometric quality of both TGAS and HST. By contrast, comparison to ground-based measurements shows that some of those must have systematic errors exceeding the random errors. Our parallax estimates have uncertainties an order of magnitude larger than previous studies, but nevertheless imply distances consistent with previous estimates. By combining our PM measurements with literature positions, distances, and radial velocities, we measure Galactocentric space motions for the clusters and find that these also agree well with previous analyses. Our analysis provides a framework for determining more accurate distances and PMs of Galactic GCs using future Gaia data releases. This will provide crucial constraints on the near end of the cosmic distance ladder and provide accurate GC orbital histories.
Relative importance of black carbon, brown carbon, and absorption enhancement from clear coatings in biomass burning emissions
Authors: Pokhrel Rudra P. , Beamesderfer Eric R. , Wagner Nick L. , Langridge Justin M. , Lack Daniel A. , Jayarathne Thilina , Stone Elizabeth A. , Stockwell Chelsea E. , Yokelson Robert J. , Murphy Shane M. 
Published: April 2017

Abstract. A wide range of globally significant biomass fuels were burned during the fourth Fire Lab at Missoula Experiment (FLAME-4). A multi-channel photoacoustic absorption spectrometer (PAS) measured dry absorption at 405, 532, and 660 nm and thermally denuded (250 °C) absorption at 405 and 660 nm. Absorption coefficients were broken into contributions from black carbon (BC), brown carbon (BrC), and lensing following three different methodologies, with one extreme being a method that assumes the thermal denuder effectively removes organics and the other extreme being a method based on the assumption that black carbon (BC) has an Ångström exponent of unity. The methodologies employed provide ranges of potential importance of BrC to absorption but, on average, there was a difference of a factor of 2 in the ratio of the fraction of absorption attributable to BrC estimated by the two methods. BrC absorption at shorter visible wavelengths is of equal or greater importance to that of BC, with maximum contributions of up to 92 % of total aerosol absorption at 405 nm and up to 58 % of total absorption at 532 nm. Lensing is estimated to contribute a maximum of 30 % of total absorption, but typically contributes much less than this. Absorption enhancements and the estimated fraction of absorption from BrC show good correlation with the elemental-carbon-to-organic-carbon ratio (EC ∕ OC) of emitted aerosols and weaker correlation with the modified combustion efficiency (MCE). Previous studies have shown that BrC grows darker (larger imaginary refractive index) as the ratio of black to organic aerosol (OA) mass increases. This study is consistent with those findings but also demonstrates that the fraction of total absorption attributable to BrC shows the opposite trend: increasing as the organic fraction of aerosol emissions increases and the EC ∕ OC ratio decreases.