bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China
Authors: Feng Weixing , Mei Shenghui , Zhu Leting , Yu Yazhen , Yang Weili , Gao Baoqin , Wu Xiaojuan , Zhao Zhigang , Fang Fang 
Published: September 2016

Background:
Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety and efficacy in treating pediatric patients with various kinds of seizures. However, interindividual variations in plasma concentrations and treatment effects of patients with epilepsy treated with VPA are observed. This study aimed to evaluate the effects of various genetic variations on normalized plasma concentration of VPA (NCVPA) and the treatment response in Chinese children with epilepsy administered with VPA.

Methods:
Pediatric patients (3 months to 18 years old) with epilepsy, taking VPA therapy, were enrolled in the study. Important genetic variations of the pharmacokinetic and pharmacodynamic pathways of VPA were evaluated using the MassARRAY system (Sequenom). The associations of genetic variations with NCVPA/drug response and the mean value of NCVPA in responsive and resistant patients were evaluated using SPSS (17.0) and Plink (1.07) software.

Results:
A total of 111 children with epilepsy (80 responsive and 31 resistant) were enrolled. rs28898617 (UGT1A6, A > G) was associated with an increase in NCVPA (β = 5.31, 95% confidence interval = 0.78–9.83, P = 0.024); therefore, patients with this variation need a lower dose of VPA. rs2279020 (GABRA1, G > A) was associated with a decreased risk of developing VPA-resistant epilepsy (odds ratio = 0.42, 95% confidence interval = 0.21–0.84, P = 0.014). Similar NCVPA was observed in resistant and responsive patients (P = 0.257).

Conclusions:
rs28898617 (UGT1A6, A > G) variation was associated with an increase in NCVPA. rs2279020 (GABRA1, G > A) variation was associated with a decreased risk of developing VPA-resistant epilepsy. Resistant and responsive patients to VPA treatment had a similar mean value of NCVPA. The findings may help clinicians to adjust the dose and predict treatment effect for children with epilepsy receiving VPA treatment.
Reconstruction after Anterior Chest Wall Keloid Resection Using Internal Mammary Artery Perforator Propeller Flaps
Authors: Ogawa Rei , Ono Shimpei , Akaishi Satoshi , Dohi Teruyuki , Iimura Takeshi , Nakao Junichi 
Published: September 2016

Background:
It is difficult to completely resect huge anterior chest wall keloids and then close the wound directly. We report here our retrospective analysis of our case series of patients with such keloids who underwent reconstruction with internal mammary artery perforator (IMAP) pedicled propeller flaps and then received postoperative high-dose-rate superficial brachytherapy.

Methods:
All consecutive patients with large/severe keloids on the anterior chest wall who underwent keloid resection followed by reconstruction with IMAP-pedicled propeller flaps and then high-dose-rate superficial brachytherapy in our academic hospital were identified. All cases were followed for >18 months. Donor site position, perforator pedicle, flap size, angle of flap rotation, complications, and recurrence were documented.

Results:
There were nine men and one woman. The average age was 37.9 years. The average follow-up duration was 28.7 months. The largest flap was 16 × 4 cm. The dominant perforators of the internal mammary artery were located in the sixth (n = 2), seventh (n = 5), eighth (n = 1), and ninth (n = 2) intercostal spaces. Twelve months after surgery, patients reported marked relief from keloid-associated pain and itching, except in two patients who underwent partial keloid resection; their remaining keloids were still troublesome but after conservative therapies, including steroid ointments/plasters, the keloids gradually ameliorated. Eighteen months after surgery, there was no keloid recurrence or new development of keloids on the donor site.

Conclusions:
IMAP-pedicled propeller flaps transfer skin tension from the anterior chest wall to the abdomen. Our series suggests that this approach combined with radiation therapy can control keloid recurrence.
Fluid resuscitation for acute kidney injury: an empty promise
Authors: Watkins Scott C. , Shaw Andrew D. 
Published: September 2016

Purpose of review
The past decade has seen more advances in our understanding of fluid therapy than the preceding decades combined. What was once thought to be a relatively benign panacea is increasingly being recognized as a potent pharmacological and physiological intervention that may pose as much harm as benefit.

Recent findings
Recent studies have clearly indicated that the amount, type, and timing of fluid administration have profound effects on patient morbidity and outcomes. The practice of aggressive volume resuscitation for ‘renal protection’ and ‘hemodynamic support’ may in fact be contributing to end organ dysfunction. The practice of early goal-directed therapy for patients suffering from critical illness or undergoing surgery appears to offer no benefit over conventional therapy and may in fact be harmful. A new conceptual model for fluid resuscitation of critically ill patients has recently been developed and is explored here.

Summary
The practice of giving more fluid early and often is being replaced with new conceptual models of fluid resuscitation that suggest fluid therapy be ‘personalized’ to individual patient pathophysiology.
Comparing the persuasiveness and professionalism of newspaper, blog, and social media sources of information in marketing and reviewing theatre
Authors: Warne Russell Thomas , Drake-Brooks Malisa M. 
Published: September 2016

Purpose
The purpose of this paper is to determine the influence that newspaper, blog and social media sources of information about a play have on respondents’ willingness to purchase a ticket to a theatrical production.

Design/methodology/approach
Respondents saw two advertisements and one review for theatrical productions. The authors randomly varied the version of each advertisement and review so that information regarding the production appeared to originate from a newspaper, blog or social media site. The authors asked respondents to rate the professionalism of the review and advertisements and how likely they were to purchase a ticket. The authors also collected demographic information.

Findings
The authors found that newspapers, blogs and social media had similar influence on respondents’ willingness to purchase a ticket. Respondents also viewed the blog-based play review as being as professional as the review from a newspaper. However, respondents were more likely to say they would purchase a ticket to a well-known play than a new play. Female respondents were more willing to purchase a play ticket.

Research limitations/implications
Implications for marketers include the usefulness of non-traditional media (e.g. blogs, social media) in promoting a play – especially for new plays. Theater critics will find that their opinions are equally influential, regardless of whether the medium of publication is traditional (e.g. a newspaper) or digital (e.g. a blog). Principal limitations are the artificiality of a true experiment and an overly simplistic pricing method in the study.

Practical implications
Professionals selling tickets to theatrical productions should use favorable quotes and responses from social media and blogs when marketing tickets because audience members trust that these sources of information as much as newspapers. Internet-based theater critics should appreciate that they are perceived as being as reputable as newspaper-based critics.

Originality/value
Research on theater advertising is extremely limited (especially outside of Broadway), as are studies on the influence of theater critics. The study adds to this meager body of research and provides needed practical guidance to theater marketers.
Governance dynamics in multi-partner R&D alliances
Authors: Barbic Frano , Hidalgo Antonio , Cagliano Raffaella 
Published: September 2016

PurposeThe purpose of this paper is to examine the dynamics of contractual and relational mechanisms during different phases of multi-partner R&D alliances.Design/methodology/approachThe paper uses a longitudinal single case study to gain in-depth understanding of which governance mechanisms are best suited for different phases of alliance collaboration. Applying a retrospective strategy for data collection, three rounds of interviews were conducted with representatives of all partner firms. The data were complemented by documentary analysis of both internal documents and publicly available information.FindingsThe findings suggest that the use of governance mechanisms in multi-partner alliances depends on the characteristics of alliance phases. Relational governance is most important in the exploration and development phases, while the importance of contractual governance comes to the fore during the development and finalization phases. Despite the predominance of one type of mechanism, the findings support a complementary perspective of governance mechanisms.Research limitations/implicationsThe results of a single case study offer limited generalizability and should thus be treated with caution. More cross-industry, cross-national studies should be conducted to verify the applicability of the findings to other industries, cultures and geographical contexts.Practical implicationsManagers should be aware that different phases of the alliance life cycle have different control and coordination needs, and should rely on different mechanisms during different phases of the alliance.Originality/valueThe authors have synthesized insights from various perspectives (transaction cost economics, organization theory, social exchange theory), and developed a multidisciplinary approach to multi-partner collaborations.
A parameterized lower confidence bounding scheme for adaptive metamodel-based design optimization
Authors: Zheng Jun , Li Zilong , Gao Liang , Jiang Guosheng 
Published: September 2016

Purpose
The purpose of this paper is to efficiently use as few sample points as possible to get a sufficiently explored design space and an accurate optimum for adaptive metamodel-based design optimization (AMBDO).

Design/methodology/approach
A parameterized lower confidence bounding (PLCB) scheme is proposed in which a cooling strategy is introduced to guarantee the balance between exploitation and exploration by varying weights of the predicting error and optimum of a metamodel. The proposed scheme is investigated by a set of test functions and a structural optimization problem, in which PLCB with four kinds of cooling control functions are studied. Moreover, other infill criteria (such as expected improvement and its extension versions) are taken into comparison.

Findings
Results show that the proposed PLCB (especially PLCB with the first cooling control function) based AMBDO method can find the optimum with fewer evaluations and maintain good accuracy, which means the proposed PLCB contributes to the excellent efficiency and accuracy in finding global optimal solutions.

Originality/value
The parameterized version of the lower confidence bound metric is proposed for AMBDO, typically used in the context of adaptive sampling in efficient global optimization.
A multi-level refinement adaptive scheme with high efficiency and accuracy
Authors: Ding Chensen , Cui Xiangyang , Li Chong , Li Guangyao , Wang Guoping 
Published: September 2016

Purpose
Traditional adaptive analysis based on a coarse mesh, using finite element method (FEM) analysis, produces the original solution. Then post-processing the result and figuring out the regions should be refined and these regions refined once. Finally, this new mesh is used to get the solution of first refinement. After several iterations of above procedures, we can achieve the last result that is closer to the true solution, which takes time, making adaptive scheme inpractical to engineering application. The paper aims to discuss these issues.

Design/methodology/approach
This paper based on FEM proposes a multi-level refinement strategy with a refinement strategy and an indicator. The proposed indicator uses value of the maximum difference of strain energy density among the elements that associated with one node, and divides all nodes into several categories based on the value. A multi-level refinement strategy is proposed according to which category the node belongs to refine different elements to different times rather than whether refine or not.

Findings
Multi-level refinement strategy takes full use of the numerical calculation, resulting in the whole adaptive analysis that only need to iterate twice while other schemes must iterate more times. Using much less times of numerical calculation and approaches, more accurate solution, making adaptive analysis more practical to engineering.

Originality/value
Multi-level refinement strategy takes full use of the numerical calculation, resulting in the whole adaptive analysis only need iterate twice while other schemes must iterate more times. using much less times of numerical calculation and approaches more accurate solution, making adaptive analysis more practical to engineering.
Rapid design optimization of antennas using variable-fidelity EM models and adjoint sensitivities
Authors: Koziel Slawomir , Bekasiewicz Adrian 
Published: September 2016

Purpose
Development of techniques for expedited design optimization of complex and numerically expensive electromagnetic (EM) simulation models of antenna structures validated both numerically and experimentally. The paper aims to discuss these issues.

Design/methodology/approach
The optimization task is performed using a technique that combines gradient search with adjoint sensitivities, trust region framework, as well as EM simulation models with various levels of fidelity (coarse, medium and fine). Adaptive procedure for switching between the models of increasing accuracy in the course of the optimization process is implemented. Numerical and experimental case studies are provided to validate correctness of the design approach.

Findings
Appropriate combination of suitable design optimization algorithm embedded in a trust region framework, as well as model selection techniques, allows for considerable reduction of the antenna optimization cost compared to conventional methods.

Research limitations/implications
The study demonstrates feasibility of EM-simulation-driven design optimization of antennas at low computational cost. The presented techniques reach beyond the common design approaches based on direct optimization of EM models using conventional gradient-based or derivative-free methods, particularly in terms of reliability and reduction of the computational costs of the design processes.

Originality/value
Simulation-driven design optimization of contemporary antenna structures is very challenging when high-fidelity EM simulations are utilized for performance utilization of structure at hand. The proposed variable-fidelity optimization technique with adjoint sensitivity and trust regions permits rapid optimization of numerically demanding antenna designs (here, dielectric resonator antenna and compact monopole), which cannot be achieved when conventional methods are of use. The design cost of proposed strategy is up to 60 percent lower than direct optimization exploiting adjoint sensitivities. Experimental validation of the results is also provided.
Mlouma: to connect the agricultural products market players
Authors: Ndour Mamour , Gueye Birahim 
Published: September 2016

Subject area
Social entrepreneurship/social innovation.

Study level/applicability
This real case targets license and master’s students as part of an ongoing course on social entrepreneurship, social innovation, in one word, on entrepreneurship.

Case overview
Mlouma is a platform based on Web, SMS, USSD, mobile application and call center. This social enterprise keeps farmers in contact with food buyers by displaying real-time market prices and localizations. The service will improve the efficiency of the agriculture supply chain, helping farmers to get a better price for their product. By introducing information and communication technology, Mlouma provides innovative solutions to the market failure by creating more value for producers and consumers.

Expected learning outcomes
This case shows the importance of the entrepreneurial orientation of social enterprises to adapt to its context and discuss theory of social entrepreneurship.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 3: Entrepreneurship.
CareCross health: private healthcare for workers
Authors: Schweer Rayner Cynthia 
Published: September 2016

Subject area
Impact investing, Social entrepreneurship.

Study level/applicability
MBA, EMBA, Executive Education.

Case overview
CareCross Health describes the impact due diligence leading up to an investment into CareCross Health by impact investor Palm Capital. The case follows the protagonist, Caitlin Stevens, CEO of Palm Capital, as she identifies CareCross Health as a potential investment target, performs an initial screening of the company and visits the company and its sites as part of an in-depth impact due diligence.

Expected learning outcomes
By the end of this case, the student should be able to consider the critical steps associated with conducting an impact due diligence; understand the challenges associated with conducting an impact due diligence, with a particular focus on due diligence in an emerging market scenario; analyse a potential impact investment, in this case CareCross Health, and make a preliminary recommendation on whether the investment is viable from an impact perspective; identify the trade-offs between private sector and public sector provision of services to low-income groups, and consider unintended consequences in analysing the impact of a social enterprise; and prepare possible scenarios and weigh the potential outcomes of various arrangements to ensure alignment of investor objectives.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 1: Accounting and Finance.
The effects of pollution prevention on performance
Authors: Graham Stephanie , McAdam Rodney 
Published: September 2016

PurposeAs pressure for companies to improve their environmental performance has intensified in recent years, research attention has shifted away from establishing a link between environmental practices and performance towards consideration of other factors that might facilitate performance improvements. The purpose of this paper is to: first, to investigate whether internal support processes interact with pollution prevention by positively moderating the relationship between pollution prevention and environmental performance; and, second, to assess whether the relationship between pollution prevention and cost performance is mediated by environmental performance.Design/methodology/approachIt uses a cross-sectional survey of 1,200 UK-based food processing firms to gather information on environmental practices and performance. Regression analysis was conducted on a sample of 149 responding firms to assess the hypothesised relationships.FindingsSupport was found for two of the four moderated relationships hypothesised namely, suggesting that internal support processes support the environmental performance of some pollution prevention practices. Strong support for a mediated relationship between pollution prevention, environmental performance and cost performance was provided by the results.Originality/valueThis study provides an original contribution to the literature on the performance outcomes of environmental practices by considering a number indirect relationships between environmental practices and performance. This has implications for the interpretation of the relationship between environmental practices and performance.
Absorptive capacity versus distributive capability
Authors: Whitehead Kimberly K. , Zacharia Zach G. , Prater Edmund L. 
Published: September 2016

Purpose
The purpose of this paper is to disentangle the role of the source and recipient of knowledge in supply chain collaboration by providing evidence that the distributive capabilities of a source, working in conjunction with the absorptive capacity (AC) of a recipient, have direct and significant effects on levels of collaborative engagement between supply chain partners and indirect and significant effects on collaborative operational outcomes.

Design/methodology/approach
This study utilises 310 surveys and structural equations modelling to provide empirical evidence to support the significance of the source of knowledge in collaborative activities.

Findings
The study provides evidence for source-based knowledge transfer constructs (distributive capabilities) in supply chain collaboration. Further, this research supports these capabilities working in conjunction with recipient AC both as necessary but insufficient requirements for successful knowledge transfer.

Practical implications
Firm interdependence within supply chains continues to grow. In today’s environment of outsourcing and increasing levels of inter-firm activities, this research provides a parsimonious model of collaboration that allows firms to understand knowledge transfer better and how to more aptly manage these types of activities and complex relationships.

Originality/value
Earlier research in this domain has focussed on the abilities of a recipient firm to absorb knowledge in order to understand successful collaborative knowledge transfer. By solely focussing on the recipient firm, the role of the source of knowledge has been largely overlooked in this stream of research.
Setting the stage for service experience: design strategies for functional services
Authors: Beltagui Ahmad , Candi Marina , Riedel Johann C.K.H. 
Published: September 2016

PurposeThe purpose of this paper is to identify service design strategies to improve outcome-oriented services by enhancing consumers’ emotional experience, while overcoming customer variability.Design/methodology/approachAn abductive, multiple-case study involves 12 service firms from diverse online and offline service sectors.FindingsOverall, six service design strategies represent two overarching themes: customer empowerment can involve design for typical customers, visibility, and community building, while customer accommodation can involve design for personas, invisibility, and relationship building. Using these strategies helps set the stage for a service to offer an emotional experience.Research limitations/implicationsThe study offers a first step toward combining investigations of service experience and user experience. Further research can strengthen these links.Practical implicationsThe six design strategies described using examples from case research offer managerial recommendations. In particular, these strategies can help service managers address the customer-induced variability inherent in services.Originality/valueExtant studies of experience staging have focused on particular sectors such as hospitality and leisure; this study contributes by investigating outcome-focused services and identifying strategies to create unique experiences that offset variability. It also represents a rare effort to combine research from service management and interaction design, shedding light on the link between service experience and user experience.