bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sevoflurane postconditioning attenuates cardiomyocyte hypoxia/reoxygenation injury via restoring mitochondrial morphology
Authors: Yu Jin , Wu Jianjiang , Xie Peng , Maimaitili Yiliyaer , Wang Jiang , Xia Zhengyuan , Gao Feng , Zhang Xing , Zheng Hong 
Published: November 2016

Background
Anesthetic postconditioning is a cellular protective approach whereby exposure to a volatile anesthetic renders a tissue more resistant to subsequent ischemic/reperfusion event. Sevoflurane postconditioning (SPostC) has been shown to exert cardioprotection against ischemia/reperfusion injury, but the underlying mechanism is unclear. We hypothesized that SPostC protects cardiomyocytes against hypoxia/reoxygenation (H/R) injury by maintaining/restoring mitochondrial morphological integrity, a critical determinant of cell fate.

Methods
Primary cultures of neonatal rat cardiomyocytes (NCMs) were subjected to H/R injury (3 h of hypoxia followed by 3 h reoxygenation). Intervention with SPostC (2.4% sevoflurane) was administered for 15 min upon the onset of reoxygenation. Cell viability, Lactate dehydrogenase (LDH) level, cell death, mitochondrial morphology, mitochondrial membrane potential and mitochondrial permeability transition pore (mPTP) opening were assessed after intervention. Mitochondrial fusion and fission regulating proteins (Drp1, Fis1, Mfn1, Mfn2 and Opa1) were assessed by immunofluorescence staining and western blotting was performed to determine the level of protein expression.

Results
Cardiomyocyte H/R injury resulted in significant increases in LDH release and cell death that were concomitant with reduced cell viability and reduced mitochondrial interconnectivity (mean area/perimeter ratio) and mitochondrial elongation, and with reduced mitochondrial membrane potential and increased mPTP opening. All the above changes were significantly attenuated by SPostC. Furthermore, H/R resulted in significant reductions in mitochondrial fusion proteins Mfn1, Mfn2 and Opa1 and significant enhancement of fission proteins Drp1 and Fis1. SPostC significantly enhanced Mfn2 and Opa1 and reduced Drp1, without significant impact on Mfn1 and Fis1.

Conclusions
Sevoflurane postconditioning attenuates cardiomyocytes hypoxia/reoxygenation injury (HRI) by restoring mitochondrial fusion/fission balance and morphology.
Inter‐Ion Mutual Repulsion Control for Nonvolatile Artificial Synapse
Authors: Lee Donghwa , Kim Minhui , Park Seonhye , Lee Seonggyu , Sung Junho , Kim Seokkyu , Kang Joonhee , Lee Eunho 
Published: September 2024

AbstractOrganic electrochemical transistors (OECTs) are promising candidates for artificial synapses to achieve high‐performance synaptic characteristics. While most research has focused on modifying the properties of organic semiconductors for efficient ion doping, there is a lack of systematic investigation into the relationship between ion‐mediated mechanisms and synaptic performance. In this study, an effective strategy for enhancing electrochemical doping and de‐doping by utilizing different coulombic anions is proposed. The findings reveal that doped ions in the channel layer affect inter‐ion interactions, influencing the non‐volatile effects by improving the doping performance of the synaptic device. Moreover, electrochemical analysis indicates that ions in the channel layer are sequentially de‐doped, enabling high linearity and symmetry. The fabricated devices demonstrate high‐performance synaptic properties including a retention time of ≈102 s with ≈50% retention over peak current and near‐ideal long‐term potentiation/long‐term depression (LTP/LTD) through effective electrochemical doping and de‐doping. These results show that controlling both the properties of organic semiconductors and ion interactions in the electrolyte is crucial for OECTs, opening up various applications for neuromorphic computing.
Reconfiguring Zn2+ Solvation Network and Interfacial Chemistry of Zn Metal Anode with Molecular Engineered Crown Ether Additive
Authors: Han Ruifeng , Jiang Tao , Wang Zhiqiao , Xue Rongrong , Liu Xinhao , Tang Yinwen , Qi Zhenhui , Ma Yue 
Published: September 2024

AbstractThe practical deployment of rechargeable aqueous zinc‐ion batteries (RAZBs) in the scaled power system suffers from unregulated Zn dendrite growth as well as parasitic reactions at the zinc foil/aqueous electrolyte interface, leading to insufficient zinc utilization and severe electrode corrosion. Herein, a novel crown ether additive is developed, with tailored molecular engineering, to stepwise regulate the Zn2+ solvation network and interfacial chemistry of Zn metal anode. The designed crown ether (C5SeCN), featuring zincophilic cyano group and hydrophobic selenium, efficiently reconstructs the solvation sheath of Zn ions at the 0.3 wt.% dose amount. Additionally, the ozone plasma treatment tethers the O2‐ groups onto the thin‐layer zinc foil, which thus binds Se atoms of the C5SeCN to the Zn anode. The Zn||Zn symmetric cells exhibit a lifespan of over 4500 h at 1 mA cm−2 and high current density endurance of up to 10 mA cm−2. Moreover, the 2 mAh cm−2 Zn||V2O5 full cell model, at the low N/P ratio of 2.8 with a lean electrolyte (E/C ratio = 10 µL mAh−1), enables robust cycling endurance at 2 A g⁻¹ for 300 cycles. This study unravels the interfacial design rationales for maximizing zinc utilization and highlights the commercial potential of crown ether additives for RAZBs development.
Electrochemical Engineering of Anode with Zincophilic Polymer Interface for Reversible Zinc Battery
Authors: Paswan Akash Mukhraj , Thakur Vikas Singh , Banerjee Swastika , Raj C. Retna 
Published: September 2024

AbstractAqueous rechargeable zinc‐ion batteries are emerging as green and safe energy devices owing to their high energy density and eco‐friendliness. The bottleneck is the inhomogeneous nucleation resulting in the growth of Zn dendrites and the parasitic side reactions at the anode. Herein, an electrochemical anode engineering strategy is demonstrated to curb the uncontrolled dendritic growth and side reactions. It involves the in situ generation of a solid‐electrolyte interface based on a Zn nanoparticle‐embedded poly(acrylic acid) hybrid layer (PAA‐nZn) on the anode. The homogeneously distributed polar functionalities and porous nature of the polymer regulate the uniform zinc ion flux, and the embedded zinc particle serves as nucleation sites for zinc plating. The hybrid layer reduces the nucleation overpotential and promotes instantaneous nucleation. The symmetrical cell made with PAA‐nZn@Zn has a lifecycle of >860 h with a voltage gap of 28 mV. The full cell fabricated by pairing the engineered anode with α‐MnO2 cathode showed a high discharge specific capacity of 238.3 mAh g−1 at 0.2 A g−1 with a capacity retention of 81.76% after 200 cycles and a long lifecycle. The electrochemical engineering of the anode suppresses the dendritic growth and protects the anode from unwanted side reactions and passivation.
Extracellular Vesicles Derived from Ligament Tissue Transport Interleukin‐17A to Mediate Ligament‐To‐Bone Crosstalk in Ankylosing Spondylitis
Authors: Wang Kaiyang , Lu Jingshun , Song Chenyu , Qiao Mu , Li Yao , Chang Menghan , Bao Hongda , Qiu Yong , Qian Bang‐Ping 
Published: September 2024

AbstractPathological new bone formation is a critical feature of the progression of ankylosing spondylitis (AS), and spine ankylosis is a distinctive feature of this condition. Ligaments are the primary regions of pathological new bone formation in AS. Here, it is demonstrated that ligament tissue‐derived extracellular vesicles (EVs) and their interleukin‐17A (IL‐17A) cargo mediate the communication between the tissue and other cells. The investigation revealed that IL‐17A in EVs can activate the JAK‐STAT3 pathway, thereby stimulating the expression of MMP14 in AS ligament. Overexpression of MMP14 can lead to changes in the cytoskeleton and mechanical signaling of mesenchymal stem cells and other cells. These alterations in cellular cytoskeleton and mechanical signaling at ligament sites in patients with AS or in stem cells treated with EVs can result in pathological new bone formation. Finally, inhibiting IL‐17A activity and EV endocytosis effectively controlled inflammation and pathological new bone formation. Overall, these data suggest that ligament‐derived EVs and the enclosed IL‐17A have a potential role in driving pathological new bone formation in AS, and targeting EVs may therefore emerge as a novel approach to delaying ectopic ossification in AS.
Dual Ionic Pathways in Semi‐Solid Electrolyte based on Binary Metal–Organic Frameworks Enable Stable Operation of Li‐Metal Batteries at Extremely High Temperatures
Authors: Nguyen Minh Hai , Ngo Nhat Minh , Kim Byung‐Kook , Park Sangbaek 
Published: September 2024

AbstractThe rapid development of the electronics market necessitates energy storage devices characterized by high energy density and capacity, alongside the ability to maintain stable and safe operation under harsh conditions, particularly elevated temperatures. In this study, a semi‐solid‐state electrolyte (SSSE) for Li‐metal batteries (LMB) is synthesized by integrating metal–organic frameworks (MOFs) as host materials featuring a hierarchical pore structure. A trace amount of liquid electrolyte (LE) is entrapped within these pores through electrochemical activation. These findings demonstrate that this structure exhibits outstanding properties, including remarkably high thermal stability, an extended electrochemical window (5.25 V vs Li/Li+), and robust lithium‐ion conductivity (2.04 × 10−4 S cm−1), owing to the synergistic effect of the hierarchical MOF pores facilitating the storage and transport of Li ions. The Li//LiFePO4 cell incorporating prepared SSSE shows excellent capacity retention, retaining 97% (162.8 mAh g−1) of their initial capacity after 100 cycles at 1 C rate at an extremely high temperature of 95 °C. It is believed that this study not only advances the understanding of ion transport in MOF‐based SSSE but also significantly contributes to the development of LMB capable of stable and safe operation even under extremely high temperatures.
Temporal trend and attributable risk factors of Alzheimer's disease and other dementias burden in China: Findings from the Global Burden of Disease Study 2021
Authors: Yang Kun , Yang Xuan , Yin Peng , Zhou Maigeng , Tang Yi 
Published: September 2024

AbstractINTRODUCTIONWe examined the burden of Alzheimer's disease and other dementias (ADOD) and attributable factors at the national and provincial levels in China.METHODSUsing the Global Burden of Diseases Study 2021, we estimated incidence, prevalence, mortality rate, disability‐adjusted life years (DALYs), and the ratio of years lived with disability (YLD) to DALYs for ADOD in China. Estimated annual percentage changes (EAPCs) were used to quantify the temporal trends from 1990 to 2021.RESULTSIn 2021, China experienced the highest ADOD burden among Group of 20 member nations. The EAPCs for age‐standardized rates for incidence, age‐standardized rates for prevalence, and age‐standardized mortality rate were 0.41 (uncertainty intervals [UIs] 0.34–0.49); 0.44 (UI: 0.36–0.52); and –0.19 (UI: ‐0.23 to ‐0.15), respectively. Between 1990 and 2021, the number of people with ADOD increased by 322.18% and DALYs associated with ADOD increased by 272.71%; most of these increases were explained by population aging.DISCUSSIONConsidering the aging Chinese population, targeted strategies to prevent dementia are urgently needed.Highlights
China experienced the highest dementia burden among Group of 20 member nations.
High body mass index, high fasting plasma glucose, and smoking were major risk factors for Alzheimer's disease and other dementias (ADOD) burden.
Since 1990, the incidence and prevalence of ADOD increased substantially in China.
The mortality rate related to ADOD decreased consistently.
Considering the aging Chinese population, targeted strategies are urgently needed.
A case of right atrial thrombus in the Chiari network after blunt cardiac rupture
Authors: Oishi Takahiro , Tamagaki Keisuke , Maruyama Shuhei , Kanayama Shuji , Wada Daiki , Yoshihara Tomoyuki , Saito Fukuki , Yoshiya Kazuhisa , Nakamori Yasushi , Kuwagata Yasuyuki 
Published: September 2024

AbstractBackgroundThe Chiari network mostly causes no symptoms but may occasionally be involved in thrombus formation in the right atrium. We present a case of right atrial thrombus discovered in the postoperative course of blunt cardiac rupture.Case PresentationA 19‐year‐old female injured in a motor vehicle accident was transported to the hospital in a state of shock. Echocardiography revealed pericardial effusion. Cardiopulmonary arrest was imminent, so a clamshell thoracotomy was performed. A laceration at the right atrial junction of the superior vena cava was observed and sutured. Echocardiography on post‐injury day 6 showed a floating thrombus in the right atrium. Anticoagulation therapy was started, the thrombus was reduced, and the patient was discharged on day 27 without sequelae. Six months later, echocardiography showed a filamentous structure and the presence of the Chiari network.ConclusionRight intra‐atrial thrombi are rare and may warrant a search of the Chiari network in conditions where hypercoagulation is anticipated.
Enantioselective Synthesis of α‐Aryl Ketones by a Cobalt‐Catalyzed Semipinacol Rearrangement
Authors: Kalomenopoulos Panagiotis G. , Emayavaramban Balakumar , Johnston Craig P. 
Published: September 2024

AbstractA highly enantioselective cobalt‐catalyzed semipinacol rearrangement of symmetric α,α‐diarylallylic alcohols is disclosed. A chiral cobalt‐salen catalyst generates a highly electrophilic carbocation surrogate following hydrogen atom transfer and radical–polar crossover steps. This methodology provides access to enantioenriched α‐aryl ketones through invertive displacement of a cobalt(IV) complex during 1,2‐aryl migration. A combination of readily available reagents, silane and N‐fluoropyridinium oxidant, are used to confer this type of reactivity. An exploration into the effect of aryl substitution revealed the reaction tolerates para‐ and meta‐halogenated, mildly electron‐rich and electron‐poor aromatic rings with excellent enantioselectivities and yields. The yield of the rearrangement diminished with highly electron‐rich aryl rings whereas very electron‐deficient and ortho‐substituted arenes led to poor enantiocontrol. A Hammett analysis demonstrated the migratory preference for electron‐rich aromatic rings, which is consistent with the intermediacy of a phenonium cation.
Molecular Photoswitching Unlocks Glucose Oxidase for Synergistically Reinforcing Fenton Reactions for Antitumor Chemodynamic Therapy
Authors: Wang Zicheng , Bao Weier , Wujieti Baerlike , Liu Ming , Li Xiaojuan , Ma Zhecheng , Cui Wei , Tian Zhiyuan 
Published: September 2024

AbstractWe have developed a new type of nanoparticles with potent antitumor activity photoactivatable via the combination of molecular photoswitching of spiropyran (SP) and enzymatic reaction of glucose oxidase (GOx). As two key processes involved therein, Fe(III)‐to‐Fe(II) photoreduction in Fe(III) metal–organic frameworks (MOFs) brings about the release of free Fe2+/Fe3+ while the photoswitching of SP to merocyanine (MC) unlocks the enzymatic activity of GOx that was pre‐passivated by SP. The release of free Fe3+ boosts its hydrolysis and therefore enables the acidification of microenvironment, which is further reinforced by one of the products of the GOx‐mediated glucose oxidation reaction, gluconic acid (GlcA). Based on the generation of Fe2+ and acidic milieu together with another product of the oxidation reaction, hydrogen peroxide (H2O2), these two processes jointly present triple enabling factors for generating lethal hydroxyl radicals (⋅OH) species via Fenton reactions and therefore oxidative stress capable of inhibiting tumor. The antitumor potency of such nanoparticle is verified in tumor‐bearing model mice in vivo, proclaiming its potential as a potent and safe agent based on the unique mechanism of optically manipulating enzyme activity for synergistic antitumor therapeutics with high spatial precision, enhanced efficacy and minimized side effects.
Na3.5(MnVFeTi)0.5(PO4)3: A Multi‐Transition‐Metal‐Ion‐Engineered NASICON‐Type Cathodes for Sodium Ion Batteries
Authors: Soundharrajan Vaiyapuri , Alfaza Ghalib , Arifiadi Anindityo , Feleke Demelash , Nithiananth Subramanian , Piao JunJi , Zeng Zhiyuan , Pham Duong Tung , Kim Chunjoong , Kim Jaekook 
Published: September 2024

AbstractElectrochemically active Na‐superionic conductor (NASICON)‐type cathodes have the structural flexibility to include various transition elements, thus enabling high power outputs benefited by multi‐electron redox reactions. This study amalgamated multiple transition metal ions to construct a new NASICON‐type cathode i. e., carbon coated Na3.5(MnVFeTi)0.5(PO4)3 (NMVFTP/C) for Na‐ion batteries (NIBs). The NMVFTP/C cathode engineered in this study demonstrated stable Na+‐storage capacity, including long‐term cycling stability up to 4000 cycles at 3000 mA g−1 with 96 % capacity retention and a high‐rate output capacity of 85.16 mAh g−1 at 2500 mA g−1. To elucidate the ion transport process within the cathode, density functional theory modeling was employed. The low energy barrier for the diffusion of Na+ in the NMVFTP/C materials was proved to be a key factor supporting our material's superior electrochemical performances.
A Network‐Constrain Weibull AFT Model for Biomarkers Discovery
Authors: Angelini Claudia , De Canditiis Daniela , De Feis Italia , Iuliano Antonella 
Published: September 2024

ABSTRACTWe propose AFTNet, a novel network‐constraint survival analysis method based on the Weibull accelerated failure time (AFT) model solved by a penalized likelihood approach for variable selection and estimation. When using the log‐linear representation, the inference problem becomes a structured sparse regression problem for which we explicitly incorporate the correlation patterns among predictors using a double penalty that promotes both sparsity and grouping effect. Moreover, we establish the theoretical consistency for the AFTNet estimator and present an efficient iterative computational algorithm based on the proximal gradient descent method. Finally, we evaluate AFTNet performance both on synthetic and real data examples.
Stakeholders' Perspectives on Current Issues in Data Monitoring Committees
Authors: Cartwright Michael J. , Friede Tim , Lawrence David , May Emma , Mütze Tobias , Roes Kit 
Published: September 2024

ABSTRACTData Monitoring Committees (DMCs) are groups of experts that review accumulating data from one or more ongoing clinical studies and advise the Sponsor regarding the continuing safety of study subjects along with the continuing validity and scientific merit of the study. Although DMCs are widely used, considerable variability exists in their conduct. This paper offers recommendations, derived from sessions given at the 2023 Central European Network International Biometric and Statisticians in the Pharmaceutical Industry Conferences' and the authors' experiences. We focus on four topics that are part of the DMC process and where there is unclarity and inconsistency in current practices: (1) Communication with the DMC—We reflect on the importance of effective, proper communication channels between the DMC and relevant stakeholders to foster collaboration and exchange of critical information while retaining study integrity throughout. (2) Open sessions—We discuss the benefits of incorporating open sessions in DMC meetings to enhance transparency, inclusivity, and the consideration of diverse perspectives, as well as pitfalls of open sessions. (3) Access to efficacy data—We highlight the need for appropriate access to efficacy data by DMCs and discuss how to implement this in practice and how to address potential concerns regarding multiplicity. (4) Interactive data displays—We outline the utilization of interactive data displays to facilitate a more intuitive understanding of study results by the DMC. By addressing these topics, we aim to provide comprehensive practical recommendations that bridge the gap between current practices and optimal DMC functionality.
3D segmentation and quantitative analysis of age‐related changes in the Hoffa fat pad using MRI
Authors: Benady Amit , Sofer Summer , Gilad Roi' , Tzoran Liat , Efrima Ben , Dadia Solomon , Vidra Matias , Rath Ehud , Amar Eyal 
Published: September 2024

AbstractThe infrapatellar fat pad (IFP), also known as the Hoffa fat pad, is an essential structure in the knee joint with diverse functions and characteristics. Pathological changes in it can lead to anterior knee pain and impingement. The aim of this study was to investigate the relationship between age and Hoffa fat pad volume. A retrospective analysis was conducted on MRI scans of 100 individuals aged 10–80 years with no Hoffa fat pad pathology. The IFP was meticulously segmented on each sagittal and coronal MRI plane and its volume was calculated on the basis of the segmented boundaries. Correlation analysis was used to explore the relationships among age, sex, height, weight, and patella‐related variables. Contrary to the hypothesis, there was no significant correlation between age and Hoffa fat pad volume. However, there were strong positive correlations between Hoffa fat pad volume and individuals' height, patellar height, and patellar ligament length. Multivariable linear regression analysis revealed that height, weight, patellar height, and patellar ligament length collectively explained 67% of Hoffa fat pad volume variability. These findings suggest that the Hoffa fat pad adapts to accommodate morphological changes in the knee joint as individuals grow taller. In conclusion, our study examined Hoffa fat pad volume in individuals across the age spectrum, using advanced imaging techniques to reveal the importance of considering height and knee‐related variables for assessing Hoffa fat pad volume. This elucidates age‐related volume changes and highlights the need for further research to understand its functional implications and interactions within the knee joint, with the aim of improving orthopedic interventions.
Doctoral‐level counselor educators and program experiences across Carnegie Classifications
Authors: Hatchett Gregory T. 
Published: September 2024

AbstractBased on online survey data provided by 163 counselor educators associated with counselor education and supervision programs, this study examined the extent to which Carnegie Classifications were associated with counselor educators’ occupational experiences and their perceptions of doctoral‐level training. Implications for doctoral training in counselor education and supervision are discussed.
Rhodium‐Catalyzed Asymmetric Transfer Hydrogenation of Aryl Ketones Involving Free Phenolic Hydroxyl Group(s)
Authors: Chang Kedi , Chou Ruilong , Yu Pinke , Zuo Linhong , Liu Qixing , Zhang Xumu , Yin Congcong , Zhou Haifeng 
Published: September 2024

AbstractA straightforward asymmetric transfer hydrogenation for accessing enantiomerically enriched secondary benzyl alcohols involving free phenolic hydroxyl group(s) under mild conditions was developed. Various of optical pure aryl alcohols with a remarkable functional group compatibility were achieved with 78 %–97 % yields, 84 %–>99 % ee's and up to 10 000 TON. This rhodium‐catalyzed reaction could be performed in a gram‐scale without loss of the efficiency. Furthermore, the synthetic utility has also been demonstrated in the asymmetric synthesis of (S)‐adrenaline and (S)‐phenylephrine.