bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatized Large Diameter Lamellar Keratoplasty and Stem Cell Transplantation for the Treatment of Ocular Surface Diseases with Limbal Insufficiency
Authors: Mendicute J. , Bidaguren A. , Martínez-Soroa I. , Gibelalde A. 
Published: January 2018

Purpose To report a new surgical procedure for the treatment of ocular surface diseases associated with severe limbal insufficiency. Methods A retrospective review of four patients with severe ocular surface disease who required stem cell transplantation and keratoplasty for the correction of limbal insufficiencies. They underwent large diameter lamellar keratoplasty with microkeratome. When limbal dysfunction was associated with limited alteration of the ocular surface and transparent deep corneal stroma only the anterior corneal stroma was transplanted. When the entire corneal thickness was compromised, both anterior and deep donor buttons were transplanted. Results Patients remained stable and improved their visual acuity after surgery. Best-corrected visual acuity ranged from 20/200 to 20/30. No corneal graft rejections were found. The main complication found in one of our patients was a central stromal opacity which required a secondary penetrating keratoplasty. Conclusions Automatized large diameter lamellar keratoplasty provides a safe and successful alternative to limbal transplantation for limbal insufficiency associated with corneal opacity. This technique enables a single-stage surgical procedure and the use of a single donor which reduces the risk of rejection. In addition, better refractive results are achieved due to the quality of the interface and the absence of corneal sutures.
Silicone Oil in the Surgical Treatment of Traumatic Endophthalmitis
Authors: Yan H. , Lu Y , Yu J. , Han J. , Zhang J. , Chen S. , Xu Y 
Published: January 2018

Purpose To explore the effects of vitrectomy combined with silicone oil injection in the treatment of traumatic endophthalmitis without retinal detachment, and analyze the relative factors. Methods Eighteen eyes of 18 patients with traumatic endophthalmitis and without retinal detachment received the treatment of vitrectomy combined with silicone oil filling. Silicone oil removal combined with intraocular lens implantations were performed in all eyes 6 months postoperatively. The visual acuity was measured by logMAR values. Preoperative visual acuity ranged from light perception to 0.1. The mean preoperative intraocular pressure was 9 mmHg with a range from 5 to 25 mmHg. Follow-up ranged from 6 to 43 months with a mean of 18 months. Results The postoperative visual acuity ranged from light perception to 0.8 at the last follow-up examination. The visual acuity increased in 15 eyes (83%), and was stable in 3 eyes (17%). The mean postoperative intraocular pressure was 17 mmHg with a range from 10 to 20 mmHg, and was significantly higher than preoperatively (p<0.05). There was no retinal detachment or ocular atrophy. Postoperative complications mainly included fibrosis exudates in the anterior chamber (18 eyes) and temporary intraocular pressure elevation (3 eyes). Conclusions Under treatment with systemic antibiotics, vitrectomy combined with silicone oil filling may be a reasonable alternative to standard endophthalmitis treatment using intravitreal antibiotics.
Intermediate Visual Acuity without Spectacles following Bilateral ReSTOR® Implantation
Authors: Cuq C. , Spera C. , Laurendeau C. , Lafuma A. , Berdeaux G. 
Published: January 2018

Purpose This survey determined uncorrected visual acuity (VA) at near, intermediate, and far distances in cataract patients implanted with ReSTOR®, and assessed patient satisfaction. Methods Consecutive cataract patients implanted bilaterally with ReSTOR® were followed up at least 4 months. The Early Treatment Diabetic Retinopathy Study scale was used to measure VA for near (40 cm), intermediate (50, 60, and 70 cm), and distance vision, with VAs expressed in logMAR and adjusted for distance using Bennett's (1993) formula. Satisfaction was self-rated on a visual analogue scale ranging from 0 (poor) to 10 (high). Results Twenty-four consecutive patients (mean age 67.6 years) were operated upon by a single surgeon and followed up for a mean of 336.5 days after second eye surgery. Average postoperative VAs for uncorrected distance were 0.06 logMAR and intermediate VAs were 0.21 logMAR at both 50 cm and 60 cm and 0.22 logMAR at 70 cm. These levels of uncorrected intermediate VA would allow patients to read Word® computer text in Times New Roman font 8 zoomed to 100%, at 70 cm from the monitor screen. The authors found that 23/24 patients (96%) no longer wore spectacles. The remaining patient required correction for astigmatism as this refraction error is not yet correctable by ReSTOR®. Average self-rated satisfaction was 8.54. Conclusions In an everyday surgical practice, none of the studied bilateral ReSTOR® cataract patients without astigmatism required spectacles when followed up 6 months or later. Intermediate VA was compatible with reading and led to high patient satisfaction.
Correlation of Disc Damage Likelihood Scale, Visual Field, and Heidelberg Retina Tomograph II in Patients with Glaucoma
Authors: Hornová J. , Kuntz Navarro J.B.V. , Prasad A. , Freitas D.G.J. , Nunes C.M. 
Published: January 2018

Purpose To correlate the analysis of the optic nerve head (ONH) obtained with Disc Damage Likelihood Scale (DDLS), Heidelberg Retina Tomograph II (HRT II), and visual field (VF) parameters (Aulhorn scale, mean deviation [MD], and pattern standard deviation [PSD]) in patients with glaucoma. Methods Sixty-five eyes were evaluated using the DDLS classification. Fifty-seven eyes had stable primary open-angle glaucoma (POAG) and eight eyes were normal (control group). Classification of the ONH was performed using the HRT II, with Moorfields Regression Analysis (MRA) and Cup Shape Measure (CSM) indexes. The VF was examined by Full Threshold test (30–2) using the Humphrey Field Analyzer (HFA) perimeter and evaluated by three methods: Aulhorn's scale of 0 to 6, and two global indices, MD and PSD. Results The amount of ONH damage as estimated by the DDLS correlated well with topographic damage determined by HRT II (r=0.923 with MRA and r=0.807 with CSM) and with visual field loss as measured by the MD (r=-0.792) and PSD (r=0.718) of the HFA and Aulhorn field staging system (r=0.849). Conclusions This study shows that evaluation of the ONH using the DDLS provides information that correlates well with VF and with data obtained from HRT II.
Nonpenetrating Deep Sclerectomy with Reticulated Hyaluronic Acid Implant versus Punch Trabeculectomy: A Prospective Clinical Trial
Authors: Russo V. , Scott I.U. , Stella A. , Balducci F. , Cosma A. , Barone A. , Delle Noci N. 
Published: January 2018

Purpose To compare the intraocular pressure (IOP)-lowering effect and complication rate of nonpenetrating deep sclerectomy (NPDS) with reticulated hyaluronic acid (SK-GEL®) scleral implant versus traditional punch trabeculectomy (PT) in the management of primary open angle glaucoma (POAG). Methods Prospective, randomized comparative study including 93 patients with uncontrolled POAG. Group 1 (43 eyes) underwent NPDS with SK-GEL® scleral implant; Group 2 (50 eyes) underwent PT Mitomycin C (0.2 mg/mL) was applied intraoperatively in both techniques. Study follow-up evaluations were conducted at 36 and 48 months. Complete success indicated the achievement of the target IOP without antiglaucoma medications, while qualified success indicated the same goal with medications. These categories were assessed at two target IOP levels, <21 mmHg and <18 mmHg. Results At 36 months for complete and qualified success with a <21 and <18 mmHg target IOP, no significant differences were noted between the two groups. At 48 months postprocedure when a <21 mmHg IOP target was considered, the rate of eyes that achieved complete success was 51.1% in the NPDS group versus 72% in the PT group (p<0.05). As for the <18 mmHg IOP target, the rate of eyes that achieved complete success was 32.5% in the NPDS group versus 44% in the PT group (p<0.05). Complications occurred significantly more frequently after PT than after NPDS. Conclusions The IOP-lowering effects of the two procedures were comparable at 36 months. At 48 months PT showed a significantly higher rate of complete success compared with NPDS. Complications were more frequent after PT than after NPDS.
Serum Haptoglobin Levels in Ocular Behçet Disease and Acute Phase Proteins in the Course of Behçet Disease
Authors: Yalçindağ F.N. , YalçIndağ A. , Çağlayan O. , Özdemir Ö. 
Published: January 2018

Purpose Changes in concentrations of acute phase proteins in the serum of patients might be significant in the pathogenesis of Behçet disease. This report investigates the association between ocular disease activity and serum haptoglobin levels in patients with Behçet disease, and summarizes the current understanding of the correlation between acute phase proteins and Behçet disease based on both personal studies and data from the literature. Methods Thirty patients with Behçet disease with ocular involvement and 15 healthy subjects were included in the study. Of the 30 patients, 14 had acute uveitis and 16 had inactive ocular involvement at the time of enrollment. Results There was a significant difference in haptoglobin levels between the patients with active ocular disease and controls (p=0.0005). There was also a significant difference in haptoglobin levels between the patients with inactive ocular disease and control subjects (p<0.0001). However, no significant difference was observed among patients with active versus inactive uveitis with regard to serum haptoglobin levels. Conclusions Higher serum haptoglobin levels in patients with Behçet disease compared to control subjects were obtained. However, elevated serum haptoglobin levels do not seem to be a risk factor for uveitis activity. Behçet disease is generally diagnosed by physical examinations and no laboratory marker has been widely accepted for follow-up of disease activity.
Retinal Nerve Fiber Layer Thickness in Congenital Color Vision Deficiency
Authors: Yilmazbas Taner P. , Onaran Z. , Ornek K. , Gullu R. 
Published: January 2018

Purpose To evaluate the thickness of the retinal nerve fiber layer (RNFL) in subjects with congenital red-green color vision deficiency (CVD). Methods This study included 20 healthy subjects with congenital red-green CVD and 22 healthy subjects with normal color vision. After Ishihara test and examinations visual field by automated perimetry, all individuals underwent scanning laser polarimetry to measure the thickness of the RNFL. Results All scanning laser polarimetry parameters related to RNFL thickness were found to be similar in subjects with congenital CVD and normal color vision (p>0.05). Conclusions This is the first report suggesting normal thickness of the RNFL in subjects with congenital red-green CVD.
Microbiologic Efficacy of 3-day Treatment with Azithromycin 1.5% Eyedrops for Purulent Bacterial Conjunctivitis
Authors: Denis F. , Chaumeil C. , Goldschmidt P. , Delval L. , Pouliquen P. , Cochereau I. , Chainier D. , De Barbeyrac B. 
Published: January 2018

Purpose Antibacterial efficacy of topically applied azithromycin 1.5% was compared with tobramycin 0.3% in a multicenter, randomized, investigator-masked study for the treatment of purulent bacterial conjunctivitis. Methods A total of 1043 adults and children received either azithromycin twice daily for 3 days (n=524) or tobramycin every 2 hours while awake for 2 days, then four times daily for 5 days (n=519). Conjunctival swabbing was taken at days 0, 3, and 9, using alginate swabs resuspended in a dissolution-transport medium, providing rapid and reproducible results. Cagle's criteria were used to define the pathogenicity level for each isolated bacterium. Results In the per-protocol set, the rate of bacteriologic resolution was 85.2% for azithromycin versus 83.8% for tobramycin on day 3, and 92.8% for azithromycin versus 94.6% for tobramycin on day 9. Azithromycin was demonstrated to be noninferior to tobramycin according to the 10% noninferiority margin. Although some bacteria were categorized as resistant to tested antibiotics, eradication was observed (for azithromycin: Acinetobacter, Enterobacteriaceae, Pseudomonas), highlighting the specific pharmacokinetics/pharmacodynamics of the ocular route. Conclusions In total, topical therapy with azithromycin 1.5% administered only twice daily for 3 days effectively eradicates most pathogenic bacteria associated with bacterial conjunctivitis. These microbiologic results are in accordance with the observed clinical outcome. This new anti-infective product has the advantage of a short treatment course which could lead to an improvement in patient compliance.
Limbal Stem Cells Transplantation in the Reconstruction of the Ocular Surface: 6 Years Experience
Authors: Wylegala E. , Dobrowolski D. , Tarnawska D. , Janiszewska D. , Gabryel B. , Małecki A. , Siekiera U. 
Published: January 2018

Purpose To analyze the graft survival rate and stability of the corneal surface in patients who underwent limbal stem cell transplantation. Three surgical techniques were performed based on the origin of the ocular surface lesion: conjunctival limbal autograft (CLAU), living-related conjunctival limbal autograft (lr-CLAL), and keratolimbal allograft (KLAL) transplantations. Methods Nonrandomized consecutive comparative case series study. Eighty-four patients (90 eyes; 31 women and 53 men; age range: 11–78 years) were included in the study. Mean follow-up was 31.2 months (range: 6–72 months). Patients were divided into three groups: CLAU, lr-CLAL, and KLAL, comprising 21, 26, and 43 eyes, respectively. Graft survival rate and clinical success of the stem cell transplantation was confirmed by impression cytology. The Kaplan Meier survival curve and generalized Peto tests were used for the analyses. Results Graft survival rate and the regularity of the corneal surface differed significantly between the allo- and autografts. The 3-year and 6-year graft survival rates were 76.1% and 61.9%, respectively, for the autologous transplantation group, and 59.4% and 46.3%, respectively, for the allogeneic transplantation group. Corneal surface restoration correlated with positive staining for corneal epithelial cells in impression cytology. Conclusions Significantly better long-term outcomes were achieved with autotransplantation of the limbus compared with allogeneic limbal grafts from living-related and cadaveric donors.
Clinical Evaluation of the Use of Infracyanine Green Staining for Internal Limiting Membrane Peeling in Epimacular Membrane Surgery
Authors: Feldman A. , Zerbib J. , Glacet-Bernard A. , Haymann P. , Soubrane G. 
Published: January 2018

Purpose To evaluate the use of infracyanine green (IFCG) staining in idiopathic epiretinal membrane (ERM) surgery. Methods A retrospective comparative study of 63 consecutive eyes with ERM operated on with internal limiting membrane (ILM) peeling using or not filtered IFCG diluted (5:1) in glucose 5%. Main outcome measures were best-corrected visual acuity, central visual field perimetry, fluorescein angiography with blue light fundus photograph, optical coherence tomography (OCT), and in seven eyes multifocal electroretinogram (mfERG). Results A total of 44 eyes underwent surgery with ILM staining using IFCG and 19 eyes without. In the IFCG group, the staining showed that the ILM was removed together with the ERM in 39% of eyes; ILM was still present on the macula after ERM removal in 57% of eyes and removed secondarily. The improvement in vision was slightly better in the IFCG group throughout follow-up but the difference was not significant. On the postoperative blue light photograph, defects in the optic nerve fibre layer were less frequent in the group with IFCG than without (p=0.023), suggesting less peroperative trauma. Two eyes in the group operated without IFCG had recurrence of the ERM including one with a macular hole vs none in the group with IFCG. No difference was observed in the groups as regards central visual field testing, mfERG, OCT, or angiographic data. Conclusions Using IFCG for ILM peeling in ERM surgery seemed to reduce significantly the trauma to the optic nerve fiber layer and to prevent ERM recurrence. Deleterious effects were not observed in this study.
Idiopathic Intracranial Hypertension after 40 Years of Age: Clinical Features in 23 Patients
Authors: Zayit-Soudry S. , Leibovitch I. , Kesler A. 
Published: January 2018

Purpose Idiopathic intracranial hypertension (IIH) is a well-recognized disorder of unknown etiology associated with elevated intracranial pressure (ICP), normal neuroimaging, and normal cerebrospinal fluid (CSF) composition, found mostly among obese females of child-bearing age. The aim of this study is to investigate the clinical features of IIH in patients older than 40 years. Methods This is a retrospective chart review (1998–2007) of all consecutive patients older than 40 years who were diagnosed with IIH based on the Modified Dandy Criteria. Results Twenty three of the 200 IIH patients in the institutional database fulfilled study entry criteria. They included 22 females and one male whose mean age was 51.4 years (range 41–79). Coexisting systemic arterial hypertension was found in 13 (56.5%) patients. Seventeen patients (73.9%) had symptoms attributable to elevated ICP. The most common presenting symptoms were visual; mainly blurred vision and transient visual obscuration (15/17 patients, 88.23%). Eleven patients (64.7%) complained of headache, and another 4 (23.5%) of pulsatile intracranial noise. The average follow up period was 21.8 months. Conclusions The findings indicate that IIH among individuals older than 40 years of age may be underreported. These patients are more likely to present with systemic hypertension and with more visual disturbances, but with fewer complaints of headache than the younger IIH population.
In Vivo Confocal Microscopy in Bilateral Herpetic Keratitis: A Case Report
Authors: Martone G. , Alegente M. , Balestrazzi A. , Nuti E. , Traversi C. , Pichierri P. , Tosi G.M. 
Published: January 2018

Purpose Bilateral herpetic keratitis is a rare infection of the cornea. Ocular herpes in atopic patients is more often bilateral, with more frequent recurrences. The authors report a case of bilateral herpes simplex virus (HSV) keratitis during the active phase studied by in vivo confocal microscopy. Methods A 28-year-old man with 5 years history of unilateral HSV keratitis and atopic dermatitis was referred to the authors for a clinical and diagnostic evaluation. Results The corneas showed the typical features of dendritic HSV keratitis in both eyes. Examination by in vivo confocal microscopy demonstrated similar lesions in both eyes: a distortion of the superficial and basal epithelium and the presence of irregular hyperreflective structures and dendritic particles near the epithelial cells. The subbasal nerve plexus presented a tortuous appearance with hyperreflective areas and beadlike formations along the fibers. After a week of antiviral treatment, in vivo confocal microscopy examination demonstrated an irregular epithelium with highly reflective deposits and reflective areas. A reduction of nerve fiber bundles with a large number of beadlike formations and abnormal tortuosity was also noted. Conclusions In vivo confocal microscopy enables a noninvasive evaluation of the ocular surface at a high magnification level. It could be useful for the early and differential diagnosis of corneal infections and when HSV keratitis recurrence is suspected.
Serous Detachment of Macula in Cystoid Macular Edema Associated with Latanoprost
Authors: Ozdemir H. , Karacorlu M. , Karacorlu S.A. 
Published: January 2018

Purpose To report serous macular detachment in two patients with cystoid macular edema (CME) associated with latanoprost. Methods Two eyes of two patients with CME associated with latanoprost underwent an ophthalmoscopic examination, fluorescein angiography, and optical coherence tomography (OCT). Results In both patients, besides CME, OCT showed serous macular detachment composed of retinal elevation over a nonreflective cavity with minimal shadowing of the underlying tissues. Conclusions This is the first case report that shows an association between serous macular detachment and CME associated with latanoprost.
Factors Affecting Intraocular Pressure Measured by Noncontact Tonometer
Authors: Yazici A. , Sen E. , Ozdal P. , Aksakal F.N. , Altinok A. , Oncul H. , Koklu G. 
Published: January 2018

Purpose To investigate the mean values of intraocular pressure (IOP) measured with non-contact tonometer (NCT) and evaluate the factors that may affect IOP. Methods A total of 850 subjects who were admitted to our clinic between March 2005 and February 2006 were recruited for the study. Subjects having blepharitis, conjunctivitis, corneal diseases, glaucoma suspicion, or glaucoma were not accepted to the study. All subjects were questioned about systemic diseases. IOP measurement with NCT and central corneal thickness (CCT) with ultrasound pachymetry were performed for each patient between 9 and 11 AM. Results The mean ages of 367 (43.2%) male subjects and 483 (56.8%) female subjects were 43.9±18.1 and 40.7±18.0 years ± SD, respectively. Since right and left eye IOP, CCT, and keratometric values were significantly correlated, right eye values were used for statistical purposes. Mean IOP values in males and females were 13.2±3.0 and 13.5±2.9 mmHg, respectively. Mean CCT values were 552.5±34.7 μm for males and 550.1±34.3 μm for females. In multiple regression analysis, IOP was found to be associated with gender, refractive error, CCT, and the presence of diabetes mellitus (DM). Conclusions Gender, CCT, the presence of DM, and refractive error may be significantly associated with IOP in this particular population.
Identification of a Novel Mutation in a Chinese Family with X-Linked Ocular Albinism
Authors: Wang Y. , Guo X. , Wei A. , Zhu W. , Li W. , Lian S. 
Published: January 2018

Purpose The purpose of the study was to evaluate the GPR143 gene (G-protein coupled receptor 143) in a Chinese three-generation family with OA1, including four carriers and a proband with clinical features of X-linked ocular albinism. Methods The proband underwent a detailed ophthalmologic evaluation. Blood samples of family members were obtained and genomic DNA isolated. Mutational analysis by SSCP and direct sequencing of the GPR143 gene was used to screen all nine exons including the intron/exon junctions. The novel mutation c.943G>T (p.G315X) found in the study was confirmed by DHPLC to exclude the possibility of polymorphism. Results Ophthalmic features of the proband were characteristic of X-linked ocular albinism. The authors identified a novel nonsense mutation p.G315X on exon 8 that was not found in 100 non-albinism subjects by DHPLC. This novel mutation in the GPR143 gene is predicted to subject to nonsense mediated decay. Conclusions The novel mutation p.G315X in the OA1 gene was identified in a Chinese family with ocular albinism, which is predicted to generate a premature stop codon. These findings extend the mutational spectrum of GPR143 gene and will be useful for gene diagnosis and genetic counseling in Chinese OA1 patients.