bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-dose ulinastatin improves postoperative oxygenation in patients undergoing aortic valve surgery with cardiopulmonary bypass: A retrospective study
Authors: Rhee Ka-Young , Sung Tae-Yun , Kim Ju Deok , Kang Hyun , Mohamad Nazri , Kim Tae-Yop 
Published: January 2018

Objective To determine whether pre-treatment with high-dose ulinastatin provides enhanced postoperative oxygenation in patients who have undergone aortic valve surgery with moderate hypothermic cardiopulmonary bypass (CPB). Methods Patients who underwent aortic valve surgery with moderate hypothermic CPB were retrospectively evaluated. In total, 94 of 146 patients were included. The patients were classified into one of two groups: patients in whom ulinastatin (10,000 U/kg followed by 5,000 U/kg/h) was administered during CPB (Group U, n = 38) and patients in whom ulinastatin was not administered (Group C, n = 56). The PaO2/FiO2 ratio was calculated at the following time points: before CPB (pre-CPB), 2 h after weaning from CPB (post-CPB), and 6 h after arrival to the intensive care unit (ICU-6). The incidence of a low PaO2/FiO2 ratio was also compared among the time points. Results Group U showed a significantly higher PaO2/FiO2 ratio (F(4, 89.0) = 657.339) and a lower incidence of lung injury (PaO2/FiO2 ratio < 300) than Group C at the post-CPB and ICU-6 time points. Conclusion High-dose ulinastatin improved pulmonary oxygenation after CPB and in the early stages of the ICU stay in patients undergoing aortic valve surgery with CPB.
Dermatological Manifestations in Patients Undergoing In Vitro Fertilisation: A Prospective Study
Authors: Sood Aradhana , Sahu Suvash , Karunakaran Sandeep , Joshi Rajneesh K. , Raman Deep Kumar 
Published: January 2018

Background: Changing sociodemographic patterns with an increase in the age of childbirth have affected fertility rates worldwide. With advancing reproductive medicine, assisted reproductive techniques (ARTs) are becoming common. While dermatological manifestations in normal pregnancies have been well documented, there is a paucity of data regarding cutaneous manifestations in patients undergoing ART. Objectives: The objectives of our study were to estimate the incidence and types of dermatological manifestations in patients undergoing in vitro fertilisation (IVF) and to study their associations with age, type of infertility, and outcome of the procedure. Methods: A prospective cohort of 200 patients undergoing IVF in a tertiary care centre was observed for occurrence of any dermatological manifestations from initiation of the IVF protocol to the outcome of the procedure at 3 weeks after embryo transfer. Results: Dermatological manifestations were seen in 27% of the study group, with urticaria being the most common cutaneous finding seen in 13.5%, followed by acneform eruptions (3%). Twenty-six (96.3%) of patients who manifested with urticaria were on progesterone. No statistically significant association was found between the occurrence of dermatological manifestations and the outcome of IVF, type of infertility, history of ART, and ovum donation in our study. Association between the age of the patient and the outcome of IVF cycle was statistically significant. Conclusion: Dermatological manifestations are seen in almost one-quarter of patients undergoing IVF, with progesterone-induced urticaria being the most common. Occurrence of cutaneous manifestations has no significant association with the outcome of IVF.
Dihydride Iron Complex Bearing a Silyl-Tethered Cyclopentadienyl Ligand
Authors: Kamitani Masahiro , Nishiguchi Yoshinori , Itazaki Masumi , Nakazawa Hiroshi 
Published: January 2018

Abstract
A silyl-tethered dihydride iron complex was synthesized by photolysis of a monohydride iron complex bearing a pendant hydrosilyl group. The coordination mode of the two hydrides and the tethered silyl ligand was investigated by 1H NMR spectroscopy and DFT calculations. Despite the Si–H interactions, the prepared complex readily eliminated molecular hydrogen upon heating or addition of L-type ligands, namely, pyridine or CO, to afford new silyl-tethered complexes. Notably, the pyridine complex exhibited alcohol dehydrogenation activity.
Hepatoblastoma: current understanding, recent advances, and controversies
Authors: Czauderna Piotr , Garnier Hanna 
Published: January 2018

Introduction: Hepatoblastoma (HB) is the most common primary malignant liver neoplasm in children. Its increasing survival rate is related to the progress in modern imaging, surgical techniques, and new chemotherapy regimens. Clinical approach: One of the past achievements was the development of the pretreatment extension of disease (PRETEXT) system. Gradually, the HB therapeutic approach has become more individualized with better stratification of patients. Controversies: These include the need for preoperative chemotherapy and its optimal duration; intensity of preoperative chemotherapy required for locally advanced cases (PRETEXT 4); optimal surgical treatment for locally advanced tumors: aggressive hepatic resections versus liver transplantation; the role of postoperative chemotherapy in the post-transplant setting; the timing and role of metastasectomy in patients with disseminated disease who undergo partial liver resection; and the prognostic significance of several HB pathology variants. Hepatoblastoma biology: Beta-catenin mutations and the beta-catenin/Wnt pathway play an important role in HB development. There have been at least two molecular signatures in HB published. Unluckily, all of these findings are based on relatively small clinical series and require confirmation. Conclusion: The treatment of HB started from one and the same therapy for all patients and aimed at increased treatment individualization, but the future seems to lie in biology-driven patient-tailored therapies.
Mitte ainult õigusest ehk Kohtuasi kui haridus- ja kirjanduslooline allikas [Abstract: Not only about justice: the court case as a source for educational and literary history]
Authors: Kaju Katre 
Published: January 2018

The aim of this article is to draw attention to numerous historical court files kept in the archives. In addition to the information related directly to the lawsuits, those documents may also contain different kind of evidence valuable for other disciplines than the history of law. This case study focuses on the materials of a singular court case at the higher regional court (Oberlandgericht) of the province of Estland: the noble family Romanowitz sued 1667 Christoph Otto Grewe for conceiving their relative Anna Catharina Romanowitz sub spe matrimonii and demanded that those two should marry. Grewe was found guilty, and had either to marry Anna Catharina Romanowitz or to pay damages. We have no information whether they eventually married or not.
Why does this particular seventeenth-century court fi le stand out? At first, it contains a handwritten poem dedicated to the name day of Anna Catharina Romanowitz – despite of its contemporary popularity there are only few seventeenth-century handwritten occasional poems left in the Estonian archives. Second, there are two letters of Grewe which may be interpreted as personal love letters or at least as highly flattering ones – again, there are not many of them preserved. Third, there is a letter from Anna Catharina Romanowitz, which is a rare case of a personal letter written by a noble woman. Fourth, letters written by the lawyers of both party and addressed to the court contain information about the reception of non-juridical literature, such as Roman authors Terence and Ovid, and highly popular novels, namely the medieval chivalric novel Amadis de Gaula and the pastoral novel The Countess of Pembroke’s Arcadia of Philip Sidney. Fifth, the letters of the lawyers may contain an early hint that the controversial work of René Descartes, Principia philosophiae, might have been known in province Estland in 1667. Sixth, these letters contain hints to several school disciplines, such as rhetoric and poetics, logic and philosophy. And seventh, most of the documents in this court file confirm and complement our knowledge about the general educational level of different social classes (noble women, common men, lawyers).
Efficacy of an imaging device at identifying the presence of bacteria in wounds at a plastic surgery outpatients clinic
Authors: Blackshaw Ellen L. , Jeffery Steven L.A. 
Published: January 2018

Objective: Current standard diagnostic practice of bacterial infections by visual inspection under white light is subjective, and microbiological sampling is suboptimal due to high false negative rates and the lengthy time needed for culture results to arrive. The MolecuLight i:X Imaging Device attempts to combat the issues faced in standard practice by providing a non-contact, real-time method of visualising bacteria within wounds. Our aim was to test this imaging device in a series of patients. Method: A single-centre prospective observational study was conducted in the Queen Elizabeth Hospital, Birmingham. During Plastic Surgery Outpatient dressings clinics, patients had their wounds photographed with the imaging device under white light and violet light illumination. Microbiological swabs were obtained of all the wounds. Any clinical signs and symptoms of infection were noted. White light and violet light photographs were compared with correlate visible clinical signs and symptoms with auto-fluorescence images. Auto-fluorescence images were then compared with the microbiological swab results to discern any differences. Results: There were 14 patients with seventeen separate wounds imaged. Of the 17, eight wounds were positive for bacterial growth on microbiological culture. All eight of these were detected positive for bacteria according to auto-fluorescence imaging. There was one wound was detected positive for bacteria by auto-fluorescence imaging with negative microbiological results. Conclusion: This study demonstrated the potential benefit of the imaging device due to the correlation between microbiological test results and auto-fluorescence imaging. The device greatly reduces the time taken waiting for results and it is simple, quick to use and non-contact. There is potential for the imaging device to guide swab sampling and aid health professionals in the diagnosis and management of wound infections.
Efficacy of hyperbaric oxygen therapy in bacterial biofilm eradication
Authors: Sanford Nicholas E. , Wilkinson Jeremy E. , Nguyen Hao , Diaz Gabe , Wolcott Randall 
Published: January 2018

Objective: Chronic wounds typically require several concurrent therapies, such as debridement, pressure offloading, and systemic and/or topical antibiotics. The aim of this study was to examine the efficacy of hyperbaric oxygen therapy (HBOT) towards reducing or eliminating bacterial biofilms in vitro and in vivo. Method: Efficacy was determined using in vitro grown biofilms subjected directly to HBOT for 30, 60 and 90 minutes, followed by cell viability determination using propidium monoazide-polymerase chain reaction (PMA-PCR). The efficacy of HBOT in vivo was studied by searching our chronic patient wound database and comparing time-to-healing between patients who did and did not receive HBOT as part of their treatment. Results: In vitro data showed small but significant decreases in cell viability at the 30- and 90-minute time points in the HBOT group. The in vivo data showed reductions in bacterial load for patients who underwent HBOT, and ~1 week shorter treatment durations. Additionally, in patients' chronic wounds there was a considerable emergence of anaerobic bacteria and fungi between intermittent HBOT treatments. Conclusion: The data demonstrate that HBOT does possess a certain degree of biofilm killing capability. Moreover, as an adjuvant to standard treatment, more favourable patient outcomes are achieved through a quicker time-to-healing which reduces the chance of complications. Furthermore, the data provided insights into biofilm adaptations to challenges presented by this treatment strategy which should be kept in mind when treating chronic wounds. Further studies will be necessary to evaluate the benefits and mechanisms of HBOT, not only for patients with chronic wounds but other chronic infections caused by bacterial biofilms.
Book Review
Authors: Hassall Graham 
Published: January 2018

Abstract
The Maxwells of Montreal, Vol 1. The Early Years 1870– 1922, Violette Nakhjavani with the assistance of Bahiyyih Nakhjavani (2011) Oxford: George Ronald, xx, 422, illus., 23.4 x 15.6 cm ISBN: 9780853985518 0853985518 (hbk) £25.95/$49.95 Kindle version: ASIN: B01C4R5CJK US$9.00.
The Maxwells of Montreal, Vol 2. Middle Years 1923–1937, Late Years 1937–1952, Violette Nakhjavani with the assistance of Bahiyyih Nakhjavani (2012) Oxford: George Ronald, 442, illus., 23.4 x 15.6 cm ISBN: 9780853985617 853985617 (hbk) £25.95/$49.95 http://www.grbooks.com
Published English-Language Letters of Shoghi Effendi During the 1920s
Authors: Smith Peter 
Published: January 2018

Abstract
During the course of his thirty-six year ministry (1922–57), Shoghi Effendi personally wrote an enormous number of letters, and in addition directed one or other of his secretaries to write numerous more on his behalf – to which he normally added a personal postscript. Most of these letters remain unpublished and there has as yet been no comprehensive study of even the published letters. What follows is a brief description of what is currently available of his English-language letters during the period 1922–30. Letters and extracts from letters appearing in periodicals such as Bahá’í News, or in compilations such as Lights of Guidance, are not included, although I do refer briefly to some unpublished letters. There is as yet no English-language study of his Persian letters.
Scholar Meets Prophet: Edward Granville Browne and Baha’u’llah (Acre, 1890)
Authors: Buck Christopher , Ioannesyan Youli 
Published: January 2018

Abstract
Rediscovery of contemporaneous handwritten notes by Cambridge orientalist, Edward Granville Browne, of his historic meetings with Baha’u’llah, prophetfounder of the Baha’i Faith in Akka (St Jean d’Acre), Palestine, during his stay there – which lasted from his arrival on Sunday, 13 April 1890, to Browne’s departure on Sunday, 20 April 1890 – significantly adds to our knowledge of those spiritual and momentous events. Given the fact that Baha’u’llah was to become widely regarded as the founder of a new world religion, Browne’s published account of his 16 April 1890 audience with Baha’u’llah takes on added significance as a rare first-hand description by a distinguished contemporary from the West. Although well-known to those acquainted with Baha’i history, relatively little is known regarding the sequence of events. This article will draw from Cambridge manuscripts to add some new details, and will draw a fuller picture of what transpired by use of Browne’s correspondence with Russian academics, along with known Baha’i sources judiciously compared with Azali sources. Together, a composite account of that historic encounter between scholar and prophet, Browne and Baha’u’llah, will be offered.
Cytotoxic Activity of 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone on Colon Cancer Cell WiDr
Authors: Ismiyati Nur , Rini Yuli Puspito , Wibowo Andi Eko , Susidarti Ratna Asmah 
Published: January 2018

Colon cancer is one of the most common death-caused cancer. The high mortality rate indicates that chemotherapy has not overcome cancer disease. Strategies and development of colon cancer treatment should be pursued. Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone is the 2ʹ,5ʹ-dihydroxychalcone derivative, of which the B ring was substituted with 2-pyridine ring. Chalcone and its derivatives have been reported to have several biological activities, such as cytotoxic, anti-inflammatory, antiHIV, and as a tyrosine kinase inhibitor. The objectives of this research was to determine the cytotoxic activity on WiDr colon cancer cells of 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone. Cytotoxic activity was measured using MTT assay. Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone inhibited WiDr cell growth with the IC50 of 16 µM. Morphology of WiDr cell showed that compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone inhibited cell growth in dose dependent.Keywords: compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone, WiDr colon cancer cell line, cytotoxic activity
Effect of Goat Milk Yogurt for Prevention Hypercholesterolamic in Animal Model Rat (Rattus norvegius) Based on the Expression of Inducible Nitric Oxide Synthase (INOS) and a description of Liver Histopathology
Authors: Mahdi Chanif , Hariyanto Sukarno , Pandaga Masdiana C. 
Published: January 2018

The pattern of high consumption of fat can lead to hypercholesterolemia were accompanied by increased levels of LDL which resulted in LDL oxidation, accompanied by an inflammatory reaction that can lead to liver tissue damage resulting in increased expression of inducible Nitric Oxide Synthase (INOS) and changes in liver histopathology. The purpose of this study was to investigate the influence of goat milk yogurt supplementation on the expression of INOS and liver histopathology picture. This study used 20 male rats, Wistar strain aged 10-12 weeks, weighing 150-200g. Giving goat milk yogurt for 42 days with a dose of 300mg/kg, 600mg/kg, and 900mg/kg and giving dietary hypercholesterolemia by administering poached quail egg yolk, lard, and cholic acid by the stomach sonde for 14 days. Parameters measured were the expression of INOS and liver histopathology picture. The analysis used in this study is the One Way Analysis Of Variance (ANOVA) followed by Tukey test 5%. The results showed that administration of goat milk yogurt as a precaution hypercholesterolemia at a dose of 300mg/kg, 600mg/kg and 900mg/kg give a highly significant effect (p <0.01) on the expression of INOS (p <0.01).The overall Result of each treatment were 0.47 ±0.03; 6.72 ± 0.11; 2.40 ±0.16;1.11 ±0.07and 0.66 ±0.19 Prevention with a dose of 900 mg/kg body weight is the most effective dose inhibits the expression of INOS. Prevention with a dose of 900 mg/kg showed that the histopathological picture of approaching normal circumstances. The conclusion of the study is the provision of goat milk yogurt as a preventive action with a dose of 900 mg/kg of the most effective to inhibit the expression of INOS and maintain normal liver histology in rats given diets hypercholesterolemia.Keywords: Hypercholesterolemia, Expression of Inducible Nitric Oxide Synthase (INOS), goat's milk yogurt, liver histopathology
Jure Leaf Extract (Nerium indium Mill.) Increased 5-Fluorouracil Sensitivity through Inhibition of NF-κB Activation and Transporter Protein in WiDr Colon Cancer Cell
Authors: Sholihah Imroatus , S. Meirizky Zulharini , Miranda Amalia , Riswansyah Refki , Jenie Riris Istighfari 
Published: January 2018

5-Fluorouracil (5-FU) is the first line chemotherapeutic agents for colon cancer therapy. Long term used of 5-FU caused cancer cell resistency. Thus, co-chemoteraputics agent should be developed to increase cells sensitivty towards 5-FU. Jure leaf (Nerium indicum Mill) extract (JLE) contains oleandrin which has cytotoxic effect on colon cancer cell. The ain of this study was to investigated the mechanism of JLE to sensitized colon cancer cell toward 5-FU through NF-κB inhibition and MRP protein repression. JLE was extracted by soxhletation method. Based on molecular docking to MRP protein, docking score of oleandrin (-50,496) was higher than native ligand ATP (-125,817). Oleandrin could interfere interaction with MRP. JLE increased 5-FU sensitivity a dose of 2 µg/mL JLE dan 12,5 µM 5-FU with the combination index (CI) of 0,594. Combination of JLE and 5-FU also inhibit p65 protein expression on WiDr cell.Keywords: cytotoxic, Nerium indicum Mill., oleandrin, immunofluorescence, molecular docking
Immunostimulant Effect of Garlic Chives Leaf Ethanolic Extract (Allium tuberosum) by Increasing Level of Antioxidant at Rats Doxorubicin-Induced Rats
Authors: Sutejo Ika Rahmawati , Ariesaka Kiky Martha , Prasetyo Fuad Adi , Taufiqurrqhman Mudzakkir , Insani Ain Yuanita , Ariansari Brilliant Givya 
Published: January 2018

Cancer is one of the leading causes of death in the world, approximately 14 million new cases and 8.2 million deaths each year. Doxorubicin is a well-known chemotherapy drug which frequently used in treating various types of cancer. However, doxorubicin posesses several side effects including cardiotoxic, hepatotoxic, nephrotoxic, and immunosuppression. One of the natural product that can be used as an adjuvant of doxorubicin to reduce the toxic effects is garlic chives (Allium tuberosum). The purpose of this study was to determine the effect of Allium tuberosum based on hematological profile, levels of CD4+, CD8+, and MDA serum of male Wistar rats which induced by doxorubicin. The hematological profile was analyzes by blood smear, levels of CD4+ and CD8+ were conducted by flowcytometry and levels of MDA serum were determined by spectrofotometry. The results showed that the etanolic extract of Allium tuberosum (EAT) increased neutrophil and lymphocyte, percentage of CD4+ cells (p<0.01) and CD8+ cells. It also decreased the levels of serum MDA (p<0.01). These results indicated that EAT work as immunostimulant possibly through an antioxidant mechanism (MDA). It can be concluded that EAT can be developed as adjuvant for doxorubicin.Keywords: doxorubicin, Allium tuberosum, immunostimulant, antioxidant, CD4+, CD8+
Some Durability Aspects of Ambient Cured Bottom Ash Geopolymer Concrete
Authors: Saravanakumar R. , Revathi V. 
Published: January 2018

Abstract
The present study examines some durability aspects of ambient cured bottom ash geopolymer concrete (BA GPC) due to accelerated corrosion, sorptivity, and water absorption. The bottom ash geopolymer concrete was prepared with sodium based alkaline activators under ambient curing temperatures. The sodium hydroxide used concentration was 8M. The performance of BA GPC was compared with conventional concrete. The test results indicate that BA GPC developes a strong passive layer against chloride ion diffusion and provides better protection against corrosion. Both the initial and final rates of water absorption of BA GPC were about two times less than those of conventional concrete. The BA GPC significantly enhanced performance over equivalent grade conventional concrete (CC).
Study of Permeability of Glass-Sand Soil
Authors: Wang F. C. , Feng X. N. , Gong H. , Zhao H. Y. 
Published: January 2018

Abstract
The drainage consolidation method has been efficiently used to deal with soft ground improvement. Nowadays, it has been suggested to use a new sand soil which is a composite of sand and recycled glass waste. The permeability performance of glass-sand soil was explored to judge the feasibility of glass-sand soil backfilled in the drainage consolidation of sand-drained ground. For comparison purposes, different mix proportions of recycled glass waste, fineness modulus, and glass particle size were analyzed to certify the impact on the permeability coefficient and the degree of consolidation. The numerical results show that adding a proper amount of recycled glass waste could promote the permeability performance of glass-sand soil, and the glasssand soil drain could be consolidated more quickly than a sand drain. Experiments showed that glass-sand soil with the a 20% mix of recycled glass waste reveals the optimum performance of permeability.