bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative effectiveness of recommended versus less intensive drug combinations in secondary prevention of acute coronary syndrome
Authors: Bezin Julien , Groenwold Rolf H.H. , Ali M. Sanni , Lassalle Régis , Robinson Philip , de Boer Anthonius , Moore Nicholas , Klungel Olaf H. , Pariente Antoine 
Published: January 2017

AbstractPurposeThe secondary prevention treatment for acute coronary syndrome (ACS) is based on the combined use of drugs from four therapeutic classes (beta‐blockers, antiplatelet agents, statins, and angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers). The objective of this study was to compare the long‐term effectiveness of the recommended therapeutic combination with those of incomplete combinations in secondary prevention of ACS.MethodsThis cohort study used data from a representative sample of the French national healthcare insurance system database. Patients hospitalised for an incident ACS between 2006 and 2011 and aged ≥20 years at the time of ACS were included in the study. Effectiveness in preventing the composite outcome ACS, transient ischemic attack, ischemic stroke or all‐cause‐death was estimated using time‐fixed and time‐dependent Cox proportional hazards models with different definitions of exposure (at inclusion or determined daily during follow‐up) and adjustment for patient characteristics, co‐morbidities and co‐medications.ResultsOf the 2874 patients included in the study, 33.9% were women; median age was 67 years (interquartile range: 56–77). The median duration of follow‐up was 3.6 years (interquartile range: 2.2–5.3). Compared with the use of recommended combination, use of combination with three classes increased the risk of the composite outcome from 1.25 (95% confidence interval (95%CI), [1.07–1.47]) in the time‐fixed model and from 1.40 (95%CI, [1.15–1.70]) or 1.42 (95%CI, [1.13–1.79]) in the time‐dependent models.ConclusionsAfter ACS, the use of incomplete drugs combinations compared with the recommended four drugs combination was associated with a higher risk of cardiovascular morbidity and all‐cause mortality. Copyright © 2017 John Wiley & Sons, Ltd.
Treatment decision making in early‐stage papillary thyroid cancer
Authors: D'Agostino Thomas A. , Shuk Elyse , Maloney Erin K. , Zeuren Rebecca , Tuttle R. Michael , Bylund Carma L. 
Published: January 2017

AbstractObjectiveThe purpose of this study was to develop an in‐depth understanding of papillary microcarcinoma (PMC) patients' decision‐making process when offered options of surgery and active surveillance.MethodsFifteen PMC patients and 6 caregivers participated in either a focus group or individual interview. Focus groups were segmented by patients' treatment choice. Primary themes were identified in transcripts using thematic text analysis.ResultsFour themes emerged from the surgery subsample: (1) Decision to undergo thyroidectomy quickly and with a sense of urgency; (2) Perception of PMC as a potentially life‐threatening disease; (3) Fear of disease progression and unremitting uncertainty with active surveillance; and (4) Surgery as a means of control and potential cure. Three themes emerged from the active surveillance subsample: (1) View of PMC as a common, indolent, and low‐risk disease; (2) Concerns about adjusting to life without a thyroid and becoming reliant on hormone replacement medication; and (3) Openness to reconsidering surgery over the long run. Two themes were identified that were shared by participants from both subsamples: (1) Deep level of trust and confidence in physician and cancer center; and (2) Use of physician and internet as primary sources of disease and treatment‐related information.ConclusionsSeveral factors influenced participants' treatment choice, with similarities and differences noted between surgery and active surveillance subsamples. Many of the emergent themes are consistent with research on decision making among localized prostate cancer patients. Findings suggest that participants from both PMC treatment subsamples are motivated to reduce illness and treatment‐related uncertainty.
Global output‐feedback stabilization for a class of stochastic nonlinear systems via sampled‐data control
Authors: Lan Qixun , Li Shihua 
Published: January 2017

SummaryIn this paper, the global sampled‐data output‐feedback stabilization problem is considered for a class of stochastic nonlinear systems. First, based on output‐feedback domination technique and emulation approach, a systematic design procedure for sampled‐data output‐feedback controller is proposed for a class of stochastic lower‐triangular nonlinear systems. It is proved that the proposed sampled‐data output‐feedback controller will stabilize the given stochastic nonlinear system in the sense of mean square exponential stability. Because of the domination nature of the proposed control approach, it is shown that the proposed control approach can also be used to handle the global sampled‐data output‐feedback stabilization problems for a more general class of stochastic non‐triangular nonlinear systems. Finally, simulation examples are given to demonstrate the effectiveness of the proposed method. Copyright © 2017 John Wiley & Sons, Ltd.
Game theory‐based global optimization for inter‐WBAN interference mitigation
Authors: Wu Tin‐Yu , Liu Wen‐Kai 
Published: January 2017

AbstractResearchers' attempts to monitor and collect environmental data have led to the emergence of Wireless Sensor Networks (WSNs). In light of WSN, the monitoring target has been changed recently from the environment to the human or animal body: sensor nodes are placed on, in, or around the body to gather biosignals, which will be stored by a wearable sink node. But, WSN has an important problem, that is, the coverage problem, which may generate interference signals and influence system reliability during data transmission. Some biosignals are very important. The reduction of system reliability due to high latency or packet loss may result in significant loss of important data and can be life‐threatening (A patient's heartbeat or breathing stops but no staff receives the medical alerts). For this reason, this study makes use of a cooperative non‐zero‐sum game model for controlling the transmit power of the system as well as reducing the obstructions between simultaneous transmissions and avoiding contention between messages. In our simulated scenario, every WBAN is a regarded as a node. To avoid the situation that any one of the sensors stops running, this study further includes a global optimization technique to cover all nodes in the game and improve the time difference of sensors' lifetime. Copyright © 2017 John Wiley & Sons, Ltd.
LATIN-MH: a model for building research capacity within Latin America
Authors: Bonini B. B. , Araya R. , Quayle J. , Silva Evangelista M. , Price LeS. N. , Menezes P. R. 
Published: January 2017

Background.Latin America Treatment and Innovation Network in Mental Health (LATIN-MH) is a research hub located in Brazil and Peru that conducts a research project to help reduce the treatment gap in mental health in Latin America (LA). Besides its research core, LATIN-MH has a Capacity Building (CB) component that aims to help young researchers receive the specific training to contribute to the growing scientific production in mental health in LA.Methods.LATIN-MH proposal in CB includes a series of actions to prepare professionals in the research area. The main proposals are described here, which include online study groups, promotion of scientific meetings, hands-on training in different levels and sharing of information.Results.LATIN-MH CB activities are at its initial stages but the proposed activities were well evaluated by the participants. The first participating fellows who finished their fellowships are contributing elsewhere in the mental treatment and human resources formation area.Conclusion.The repercussion of LATIN-MH actions in CB and its evaluation, particularly on the formation of human resources and dissemination of information, show that the hub is contributing to the critic formation of young researchers and the circulation of important information.
Anticancer Drug Camptothecin Test in 3D Hydrogel Networks with HeLa cells
Authors: Liang Jun , Susan Sun Xiuzhi , Yang Zhilong , Cao Shuai 
Published: February 2017

AbstractDevelopment of a biomimetic 3D culture system for drug screening is necessary to fully understand thein vivoenvironment. Previously, a self-assembling peptide hydrogel has been reported; the hydrogel exhibited physiological properties superior to a 3D cell culture matrix. In this work, further research using H9e hydrogel with HeLa cells was carried out considering H9e hydrogel’s interaction with camptothecin, a hydrophobic drug. According to AFM images, a PGworks solution triggered H9e hydrogel fiber aggregation and forms a 3D matrix suitable for cell culture. Dynamic rheological studies showed that camptothecin was encapsulated within the hydrogel network concurrently with peptide self-assembly without permanently destroying the hydrogel’s architecture and remodeling ability. Fluorescence measurement indicated negligible interaction between the fluorophore part of camptothecin and the hydrogel, especially at concentration 0.25 and 0.5 wt%. Using a dialysis method, we found that H9e hydrogel could not significantly inhibit the diffusion of camptothecin encapsulated inside the hydrogel matrix. In the cell culture experiment, HeLa cells were simultaneously embedded in the H9e hydrogel with the initialization of hydrogelation. Most importantly, cell viability data after camptothecin treatment showed responses that were drug-dose dependent but unaffected by the H9e hydrogel concentration, indicating that the hydrogel did not inhibit the drug.
Preamble‐based synchronisation scheme for electromagnetic wireless nanocommunications
Authors: Singh Pankaj , Kim Byung Wook , Jung Sung Yoon 
Published: January 2017

Terahertz band (0.1–10 THz) nanocommunications are expected to have a plethora of biomedical, industrial, and military applications. A pulse‐based modulation scheme could enable communications among nano‐devices. Nevertheless, synchronisation could be a significant performance limiting factor and an arduous task to accomplish considering the huge bandwidth of the transmitted pulse, and the simple design and energy constraint requirements of the nano‐transceivers. This study proposes a novel synchronisation scheme for pulse‐based nanocommunication based on a continuous‐time moving average (CTMA) algorithm. Since CTMA uses an energy collection approach, it does not increase the energy and complexity requirements of nano‐transceivers. This approach is based on continuously moving sub‐integration windows and searching for the maximum energy over the entire preamble duration. The simulation results showed that using the proposed scheme, for a distance of up to 5 mm, a synchronisation probability of >0.7 was obtained for a signal energy to noise ratio (SNR) of 20 dB. The results showed good performance in terms of the tradeoff among the synchronisation probability, SNR, and distance between nanonodes. Moreover, synchronisation error was also evaluated to check the overall performance of the scheme. Altogether, the proposed scheme makes an appropriate step forward to enable nanocommunication among resource‐constrained nanonetworks.
FIMPsy – Fragebogen zur Inanspruchnahme medizinischer und nicht medizinischer Versorgungsleistungen bei psychischen Erkrankungen: Entwicklung und Verwendung
Authors: Grupp Helen , König Hans-Helmut , Riedel-Heller Steffi , Konnopka Alexander 
Published: January 2017

Zusammenfassung
Ziel der Studie Entwicklung eines Instruments zur Erfassung der Leistungsinanspruchnahme bei psychischen Erkrankungen.
Methodik Es wurde nach Leistungen zur Versorgung von Menschen mit psychischen Erkrankungen recherchiert. Häufig in Anspruch genommene Leistungen wurden zu Leistungskomplexen zusammengefasst.
Ergebnisse Der FIMPsy ermöglicht die retrospektive Erfassung der Inanspruchnahme medizinischer und nicht medizinischer Leistungen bei Patienten mit psychischen Erkrankungen über einen Zeitraum von 6 Monaten.
Schlussfolgerung Der FIMPsy deckt weite Bereiche der Versorgung von Menschen mit psychischen Erkrankungen ab und kann in ökonomischen Evaluationsstudien eingesetzt werden.
Fast propagation regions cause self-sustained reentry in excitable media
Authors: Zykov Vladimir , Krekhov Alexei , Bodenschatz Eberhard 
Published: January 2017

Significance
Rotating spiral waves have been observed in a wide variety of nonlinear spatially distributed systems in physics, chemistry, and biology, called excitable media. In medicine, they are associated with cardiac arrhythmias. Nevertheless, how exactly these waves are initiated in excitable tissue remains largely unknown. Several candidate mechanisms have been proposed over the last century, largely based on the assumption of wave breaking due to unexcitable obstacles or the medium’s refractoriness. Here, we have identified a generic mechanism for self-sustained spiral wave generation in inhomogeneous excitable media by localized regions with the fast propagation velocity. We believe our theory creates constructive options to fight these deadly phenomena.
Filopodia formation and endosome clustering induced by mutant plus-end–directed myosin VI
Authors: Masters Thomas A. , Buss Folma 
Published: February 2017

SignificanceHow the mechanical properties of myosin motors relate to their functions in cells is poorly understood. Myosin VI (MYO6) is the only myosin that moves to the minus end of actin filaments, but the cellular requirement of this reverse movement is unknown. To investigate this question, we generated a mechanical mutant of MYO6, MYO6+, which moves to the plus end of actin filaments. This mutant causes clustering of signaling endosomes coupled to reorganization of cortical actin filaments into elongated filopodia. These two phenotypes depend on the multimerization of MYO6+ on the endosomal membrane induced by binding to lipids and adaptor proteins. Our results highlight the importance of endosomes for myosin-dependent regulation of cortical actin filaments in mammalian cells.
Flow-assisted assembly of nanostructured protein microfibers
Authors: Kamada Ayaka , Mittal Nitesh , Söderberg L. Daniel , Ingverud Tobias , Ohm Wiebke , Roth Stephan V. , Lundell Fredrik , Lendel Christofer 
Published: January 2017

Significance
Protein nanofibrils formed by self-assembly have emerged as a promising foundation for the design of bio-based materials with enhanced mechanical properties or new functionality. To make use of the extraordinary properties of these structures in materials design, improved understanding of the assembly of the nanofibrils into macroscale materials is crucial. Here we demonstrate that micrometer-sized protein fibers can be created from protein nanofibrils using a simple microfluidics setup. The assembly mechanism of these fibers is elucidated using high-resolution small-angle X-ray studies in combination with rheology measurements of the corresponding hydrogels. The results reveal essential parameters associated with the fiber formation and provide insights about the assembly processes of hierarchical protein materials.
Interactive analysis of Long-read RNA isoforms with Iso-Seq Browser
Authors: Hu Jingyuan , Uapinyoying Prech , Goecks Jeremy 
Published: January 2017

AbstractBackgroundLong-read RNA sequencing, such as Pacific Biosciences’ Iso-Seq method, enables generation of sequencing reads that are 10 kilobases or even longer. These reads are ideal for discovering splice junctions and resolving full-length gene transcripts without time-consuming and error-prone techniques such as transcript assembly and junction inference.ResultsIso-Seq Browser is a Web-based visual analytics tool for long-read RNA sequencing data produced by Pacific Biosciences’ isoform sequencing (Iso-Seq) techniques. Key features of the Iso-Seq Browser are: 1) an exon-only web-based interface with zooming and exon highlighting for exploring reference gene transcripts and novel gene isoforms, 2) automated grouping of transcripts and isoforms by similarity, 3) many customization features for data exploration and creating publication ready figures, and 4) exporting selected isoforms into fasta files for further analysis. Iso-Seq Browser is written in Python using several scientific libraries. The application and analyses described in this paper are freely available to both academic and commercial users athttps://github.com/goeckslab/isoseq-browserConclusionsIso-Seq Browser enables interactive genome-wide visual analysis of long RNA sequence reads. Through visualization, highlighting, clustering, and filtering of gene isoforms, ISB makes it simple to identify novel isoforms and novel isoform features such as exons, introns and untranslated regions.
Multple-trait Bayesian Regression Methods with Mixture Priors for Genomic Prediction
Authors: Cheng Hao , Kizilkaya Kadir , Zeng Jian , Garrick Dorian , Fernando Rohan 
Published: January 2017

ABSTRACTBayesian multiple-regression methods incorporating different mixture priors for marker effects are widely used in genomic prediction. Improvement in prediction accuracies from using those methods, such as BayesB, BayesC and BayesCπ, have been shown in single-trait analyses with both simulated data and real data. These methods have been extended to multi-trait analyses, but only under a specific limited circumstance that assumes a locus affects all the traits or none of them. In this paper, we develop and implement the most general multi-trait BayesCΠ and BayesB methods allowing a broader range of mixture priors. Further, we compare them to single-trait methods and the “restricted” multi-trait formulation using real data. In those data analyses, significant higher prediction accuracies were sometimes observed from these new broad-based multi-trait Bayesian multiple-regression methods. The software tool JWAS offers routines to perform the analyses.
Early frameshift alleles of zebrafishtbx5athat fail to develop the heartstrings phenotype
Authors: Chiavacci Elena , Kirchgeorg Lucia , Felker Anastasia , Burger Alexa , Mosimann Christian 
Published: January 2017

ABSTRACTTbx5 is a key transcription factor for vertebrate heart and forelimb development that causes Holt-Oram syndrome when mutated in humans. The classic zebrafish mutant fortbx5anamedheartstrings (hst)features recessive absence of pectoral fins and a spectrum of heart defects, most-prominently featuring the name-giving stretched heart tube. The mutation of thehstallele is a stop codon that is predicted to result in a truncated Tbx5a protein that might feature residual activity. Here, using CRISPR-Cas9 mutagenesis, we generated zebrafish strains for two newtbx5aframeshift alleles in the first coding exon:tbx5a c.21_25delandtbx5a c.22_31del,abbreviated astbx5aΔ5andtbx5aΔ10. Homozygous and trans-heterozygous combinations of these newtbx5aalleles cause fully penetrant loss of pectoral fins and heart defects including changes in cardiac marker expression akin tohstmutants. Nonetheless, distinct fromhstmutants, homozygous and trans-heterozygous combinations of thesetbx5aframeshift mutants do not readily manifest the stretchedhstheart phenotype. Our observation points out the importance and value of comparing phenotypes from different classes of mutant alleles per gene.
Understanding link sharing tools continuance behavior in social media
Authors: Sun Jianjun , Sheng Dongfang , Gu Dongxiao , Du Jia Tina , Min Chao 
Published: January 2017

PurposeThe purpose of this paper is to investigate the continued use behavior (CU) of link sharing tools based on uses and gratifications theory, the theory of planned behavior and expectation confirmation theory. It then builds a conceptual model that is empirically tested.Design/methodology/approachData were collected from 343 students (undergraduates, masters, PhD students, and MBAs) from three Chinese universities via a two-phrase survey. The tools SPSS 18.0 and AMOS 18.0 were used to analyse the reliability, validity, model fits and SEM, respectively.FindingsThe results indicate that an individual’s CU of link sharing tools was determined by his or her continued use intention directly and subjective norm indirectly. Users’ satisfaction on link sharing tools was the main factor affecting the continuance intention. Individuals’ motivation needs such as cognitive needs, personal integrative needs, and social integrative needs were found to be the significant predictors of his or her satisfaction. Besides, people with high privacy concern tended to have less satisfaction with link sharing tools.Originality/valueThis study explores users’ CU of link sharing tools in social media for the first time. The theoretical model developed shows the predictors behind people’s CU.
Structure and thermal behavior of lead-free solders prepared by rapid solidification of their melt
Authors: Durisin Martin , Pietrikova Alena , Durisin Juraj , Saksl Karel 
Published: January 2017

Purpose
The paper aims to investigate the structure and thermal stability of newly developed lead-free Sn-based alloys which can be used as novel materials in the soldering of electronic components.

Design/methodology/approach
Rapid solidification was used to prepare the alloys.

Findings
The results showed that the microstructure of these solders exhibited uniform distribution and small-sized intermetallic compounds. Also, smaller crystalline size can be expected compared to commercially available counterparts. The analyses revealed a uniform and homogenous distribution of the small intermetallic particles of Cu6Sn5 and Ag4Sn in the microstructure of solders. The practical implications mean an improvement in mechanical properties and thermal stability of such solder joints, which is a precondition of low mechanical, thermo-mechanical stresses in their structure.

Originality/value
The originality lies in the production of these alloys by the melt spinning technique which was not previously used in the electronics industry.
Experimental Hendra virus infection of dogs: virus replication, shedding and potential for transmission
Authors: Middleton DJ , Riddell S , Klein R , Arkinstall R , Haining J , Frazer L , Mottley C , Evans R , Johnson D , Pallister J 
Published: January 2017

ObjectiveCharacterisation of experimental Hendra virus (HeV) infection in dogs and assessment of associated transmission risk.MethodsBeagle dogs were exposed oronasally to Hendra virus/Australia/Horse/2008/Redlands or to blood collected from HeV‐infected ferrets. Ferrets were exposed to oral fluids collected from dogs after canine exposure to HeV. Observations made and samples tested post‐exposure were used to assess the clinical course and replication sites of HeV in dogs, the infectivity for ferrets of canine oral fluids and features of HeV infection in dogs following contact with infective blood.ResultsDogs were reliably infected with HeV and were generally asymptomatic. HeV was re‐isolated from the oral cavity and virus clearance was associated with development of virus neutralising antibody. Major sites of HeV replication in dogs were the tonsils, lower respiratory tract and associated lymph nodes. Virus replication was documented in canine kidney and spleen, confirming a viraemic phase for canine HeV infection and suggesting that urine may be a source of infectious virus. Infection was transmitted to ferrets via canine oral secretions, with copy numbers for the HeV N gene in canine oral swabs comparable to those reported for nasal swabs of experimentally infected horses.Conclusion
HeV is not highly pathogenic for dogs, but their oral secretions pose a potential transmission risk to people. The time‐window for transmission risk is circumscribed and corresponds to the period of acute infection before establishment of an adaptive immune response. The likelihood of central nervous system involvement in canine HeV infection is unclear, as is any long‐term consequence.