bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Pid-Fuzzy Berbasis Ladder Diagram Untuk Kontrol Kecepatan Dan Posisi Sejajar 2 Benda
Authors: Utomo Eko Budi , Ningrum Endah Suryawati 
Published: September 2024

Pada penelitian ini diimplementasikan sistem kontrol kecepatan dan posisi sejajar 2 benda pada conveyor yang berbeda. Setiap conveyor memiliki sensor jarak. Selisih data jarak pada masing masing conveyor digunakan untuk kontrol posisi sejajar saat conveyor aktif. Selain itu terdapat variasi beban yang perlu dikontrol untuk tetap mencapai kecepatan yang diperlukan. Sistem ini menggunakan hardware (PLC Siemens S7-300), Software (Simatic Manager), dan mekanik berupa motor conveyor untuk sinkronisasi posisi 2 benda. Pada Fuzzy terdapat 4 input dan 1 output berupa setpoint kecepatan motor. Setpoint ini diproses oleh kontrol PID dengan umpan balik yang berasal dari data rotary encoder atas kecepatan motor yang berubah karena variasi beban. Program Fuzzy-PID diimplemetasikan dengan instruksi dasar (tidak menggunakan fitur add-on software atau Function Block) dan ditanam pada 2 buah PLC yang saling berkomunikasi. Hasil pengujian kecepatan motor paling cepat dan stabil pada 50 rpm terhadap variasi beban 2.5 kg sampai 9.5 kg dengan respon waktu kembali menuju steady state sebesar 200ms (pemberian beban) dan sebesar 350 ms (pelepasan beban). Hasil output fuzzy1 mempunyai galat rata-rata sebesar 5% dan output fuzzy 2 sebesar 5.7%.
ANALISIS PRIORITAS PENANGANAN PERMUKIMAN KUMUH PERKOTAAN DI KECAMATAN KENDARI BARAT
Authors: Regina Ayu , Kadir Ishak , Golok Jaya La Ode Muh 
Published: September 2024

Permukiman kumuh dicirikan dengan tidak atau kurang infrastruktur dan kondisi hunian yang tidak layak. Penelitian ini bertujuan menganalisis karakteristik tingkat kekumuhan permukiman, menganalisis prioritas penanganan permukiman kumuh dan merumuskan konsep dan strategi penanganan permukiman kumuh di Kecamatan Kendari Barat. Perumusan skala prioritas menggunakan metode Analytical Hierarchy Process (AHP) dengan menguraikan tujuan, perumusan kriteria dan memilih prioritas penanganan berdasarkan penjumlahan bobot dari setiap kriteria penilaian.Berdasarkan analisis tingkat kekumuhan, prioritas penanganan permukiman kumuh berdasarkan tingkat kekumuhan meliputi 6 (enam) Kelurahan dengan tingkat kumuh ringan melalui pola penanganan peremajaan. Prioritas penanganan permukiman kumuh di Kecamatan Kendari Barat berdasarkan kriteria kondisi fisik lingkungan yaitu proteksi kebakaran (0,30), bangunan gedung (0,16), penyediaan air minum (0,14), drainase lingkungan (0,14), pengelolaan air limbah (0,11), pengelolaan persampahan (0,10) dan jalan lingkungan (0,04). Selain pembangunan infrastruktur yang berkelanjutan dan berwawasan lingkungan, dukungan pemerintah daerah, pemerintah pusat, pihak swasta dan masyarakat dalam peningkatan kualitas permukiman kumuh seperti peraturan penanganan, antisipasi tumbuhkan permukiman kumuh baru, perencanaan secara kompreshensif dan berkelanjutan, menciptakan lapangan kerja atau sumber perekonomian baru dan kesadaran tentang budaya hidup sehat bagi masyarakat yang bermukim di permukiman kumuh Kecamatan Kendari Barat. Kata Kunci : Permukiman Kumuh, Prioritas, Penanganan
Establishment of reference intervals of thyroid-related hormones for adults with normal liver function in Zhejiang Province by indirect method
Authors: Huang Xiying , Yang Xufeng 
Published: September 2024

ObjectiveThyroid disorders are prevalently diagnosed yet face significant challenges in their accurate identification in China. Predominantly, the reference intervals (RIs) currently in use across Chinese medical facilities derive from company-provided data, lacking stringent scientific validation. This practice underscores the urgent necessity for establishing tailored RIs for thyroid-related hormones, specifically tailored to the coastal area populations. Such refined RIs are imperative for empowering clinicians with the precise tools needed for the accurate diagnosis of both overt and subclinical thyroid conditions.MethodsThis investigation analyzed the medical histories of 6021 euthyroid individuals mainly from East coastal area of China between June 2019 and December 2020. The cohort comprised residents of coastal areas, focusing on extracting insights into the regional specificity of thyroid hormone levels. A thorough examination protocol was implemented, encompassing inquiries into thyroid health history, ultrasound screenings, palpations during thyroid surgery, detections of thyroid antibodies, and reviews of medication histories. Adherence to the CLSI C28-A3 guidelines facilitated the derivation of RIs for thyroid-related hormones, subsequently juxtaposed against those provided by commercial entities.ResultsThe study delineated the following gender- and age-specific RIs for Thyroid-Stimulating Hormone (TSH): for males under 50 years, 0.57-3.37; males over 50 years, 0.51-4.03; females under 50 years, 0.53-3.91; and females over 50 years, 0.63-4.31. Further analysis revealed the RIs for Free Thyroxine (FT4), Free Triiodothyronine (FT3), Total Thyroxine (TT4), and Total Triiodothyronine (TT3) amongst males and females, with notable distinctions observed between the two genders and across age brackets. These findings are in stark contrast to the standardized intervals provided by manufacturers, particularly highlighting differences in TT3 and FT3 levels between genders and a tendency for TSH levels to increase with age.ConclusionThis research successfully establishes refined RIs for thyroid-related hormones within the Chinese coastal area populations, taking into account critical demographic factors such as gender and age. These tailored RIs are anticipated to significantly enhance the diagnostic accuracy for thyroid diseases, addressing the previously noted discrepancies with manufacturer-provided data and underscoring the importance of regionally and demographically adjusted reference intervals in clinical practice.
Epidemiology of intrapartum stillbirth and associated factors among women who gave childbirth in Ethiopia: systematic review and meta-analysis
Authors: Israel Eskinder , Abraham Awoke , Tesfaw Mihiret , Geta Temesgen , Kercho Melkamu Worku , Dubale Samson , Yakob Tagese , Jambo Endale , Elfios Eshetu 
Published: September 2024

BackgroundStillbirth always resulted in a multi-dimensional impact from the individual level to the country level at large. It causes psychological depression, social stigmatization, and decreased quality of life for women. Despite several studies conducted in Ethiopia, no national pooled estimates were done. Therefore, this systematic review and meta-analysis sought to assess intrapartum stillbirth and associated factors among women who had childbirth in Ethiopia using the available published evidence.MethodsThe current review included studies conducted in Ethiopia. The databases used primarily were Medline/PubMed, Google Scholar, Scopus, Web of Science, Ethiopian University Repository Online, CINAHL, African Journals Online and Cochrane Library. All cross-sectional studies conducted in English and met eligibility criteria were included in the final review. A random-effects meta-analysis was performed. Data extraction and analysis were also performed using Microsoft Excel and STATA version 14 software respectively.ResultsIn the current review, eleven studies were included, and their quality was assessed before being chosen for the final review. The pooled prevalence of intrapartum stillbirth among women who had childbirth in Ethiopia was 9.21% [95% CI (7.03%, 11.39%); I2 = 90.2, P = 0.000]. Women with a previous history of stillbirth [OR = 5.14, 95% CI (3.53–6.75), I2 = 60.0%, p = 0.04] and had no use of antenatal care {[OR = 0.43, 95% CI (0.18–0.68) I2 = 85.3%, p = 0.001]} were significantly associated with intrapartum stillbirth among women who gave childbirth.ConclusionsNearly one-tenth of women who had childbirth in Ethiopia had an intrapartum SB. Revitalizing the existing health extension package particularly family health services with emphasis on focused antenatal care and counselling as well as with prompt referral system would reduce intrapartum SB. This review calls for the need to assess the quality of ANC provision and tailor targeted interventions to best improve the service quality.
Causal roles of skin and gut microbiota in skin appendage disorders suggested by genetic study
Authors: Zhu Yuhang , Liu Wanguo , Wang Mei , Wang Xu , Wang Sibo 
Published: September 2024

ObjectivesThere is evidence from observational studies that human microbiota is linked to skin appendage Disorders (SADs). Nevertheless, the causal association between microbiota and SADs is yet to be fully clarified.MethodsA comprehensive two-sample Mendelian randomization (MR) was first performed to determine the causal effect of skin and gut microbiota on SADs. A total of 294 skin taxa and 211 gut taxa based on phylum, class, order, family, genus, and ASV level information were identified. Summary data of SADs and eight subtypes (acne vulgaris, hidradenitis suppurativa, alopecia areata, rogenic alopecia, rosacea, rhinophyma, seborrhoeic dermatitis, and pilonidal cyst) were obtained from the FinnGen consortium. We performed bidirectional MR to determine whether the skin and gut microbiota are causally associated with multiple SADs. Furthermore, sensitivity analysis was conducted to examine horizontal pleiotropy and heterogeneity.ResultsA total of 65 and 161 causal relationships between genetic liability in the skin and gut microbiota with SADs were identified, respectively. Among these, we separately found 5 and 11 strong causal associations that passed Bonferroni correction in the skin and gut microbiota with SADs. Several skin bacteria, such as Staphylococcus, Streptococcus, and Propionibacterium, were considered associated with multiple SADs. As gut probiotics, Bifidobacteria and Lactobacilli were associated with a protective effect on SAD risk. There was no significant heterogeneity in instrumental variables or horizontal pleiotropy.ConclusionsOur MR analysis unveiled bidirectional causal relationships between SADs and the gut and skin microbiota, and had the potential to offer novel perspectives on the mechanistic of microbiota-facilitated dermatosis.
Transcultural adaptation and theoretical models validation of the Spanish version of the Self-Care of Diabetes Inventory
Authors: Martínez-Tofé Jesús , Ausili Davide , Soto-Ruiz Nelia , Santolalla-Arnedo Iván , Durante Angela , di Nitto Marco , Lysanets Yuliia , de Viñaspre-Hernández Regina Ruiz , Tejada-Garrido Clara Isabel , Sánchez Barba Mercedes , Gea-Caballero Vicente , Juárez-Vela Raúl 
Published: September 2024

BackgroundFor patients with diabetes mellitus, self-care is crucial because it prevents complications and helps preserve quality of life. Clinicians and researchers require effective tools for assessing self-care behaviors across various dimensions to identify individual needs and maximize resource allocation. The aim of this study was to evaluate the validity and reliability of the Spanish version of the Self-Care of Diabetes Inventory (SCODI).MethodsTwo hundred eighteen participants with DMT1 and DMT2 who were recruited through convenience sampling from a university hospital participated in our cross-sectional study. After translation and cultural adaptation, the enrolled patients answered the questions. We performed an exploratory factor analysis (EFA) on each of the SCODI scales and Confirmatory factor analysis (CFA) was performed using our models which appropriate fit indices.ResultsThe original structure of the four-dimensions tool was confirmed. The overall consistency across the four scales was assessed by Cronbach’s alpha: self-care maintenance (0.766), self-care monitoring (0.790), self-care management (0.771), and self-care confidence (0.936). The model fit yielded a chi-square index of 1.028 with 773 degrees of freedom. Confirmatory factor analysis showed a good fit, thereby affirming the reliability of the model.ConclusionThe internal consistency and reliability of the SCODI Spanish version are deemed adequate. This tool is appropriate when it is desired to evaluate the self-care practices of Spanish persons suffering from diabetes due to its good psychometric qualities.
Current interventional model for movement in Parkinson’s disease: network meta-analysis based on the improvement of motor ability
Authors: HongFei Zhao , Li Zhang , Liang Li , Ru Guo Wan , Yi Huang Lan , Zhen Wang 
Published: September 2024

AimTo identify optimally therapeutic exercise interventions for improving motor ability among patients with Parkinson’s disease (PD), we conducted a network meta-analysis (NMA) of randomized controlled trials comparing different exercise regimens.MethodsRelevant RCTs were retrieved by searching PubMed, Embase, Cochrane, Web of Science, CINAHL, CBM, China National Knowledge Infrastructure (CNKI), Wan fang, VIP, and other databases from inception to July 9, 2023 is available in English as the primary language. Exercise outcomes as measured by Movement Disorder Society- Unified Parkinson’s Disease Rating Scale Part III (MDS-UPDRS-III) score change were evaluated and ranked using STATA software version 18.0. All included studies were assessed for methodological quality using the Cochrane Risk of Bias tool.ResultsThe final NMA included 71 studies involving 3,732 participants, 87 intervention experiments, and 27distinct interventions. Although most exercise interventions showed some efficacy (reducing MDS-UPDRS-III score), cumulative ranking probability surface (SUCRA) values indicated that the best exercise interventions for motor function improvement were archery (95.6%), riding a bicycle (80.9%), and binary rhythm dance (80.8%).ConclusionAn exercise intervention comprising archery, cycling, and(or) binary rhythm dance may yield superior improvements in motor function among patients with Parkinson’s disease.
Large-scale genome-wide association studies reveal the genetic causal etiology between ankylosing spondylitis and risk of leukemia and lymphocytic malignancies
Authors: Li Guang , Dong Changhu , Song Yanping , Gao Fei 
Published: September 2024

BackgroundEvidence from multiple observational studies suggests that ankylosing spondylitis (AS) is associated with leukemia and lymphocytic malignancies. However, the obtained results are inconsistent, and the causal relationship still needs to be determined. In this context, we utilized two-sample Mendelian randomization (MR) to investigate potential causal associations between AS and leukemia and lymphocytic malignancies.MethodsThe analysis was conducted through published genome-wide association studies (GWAS). We obtained genetic data on AS as the exposure and leukemia, including lymphocytic leukemia, myeloid leukemia, and lymphocytic malignancies including lymphoma, multiple myeloma (MM) as the endpoint. The main method to evaluate causality in this analysis was the inverse variance weighting (IVW) technique. Additionally, we employed the weighted mode, weighted median, and MR-Egger regression for supplementary analyses. Finally, heterogeneity tests, sensitivity analyses, and multi-effect analyses are carried out.ResultsIn a random-effects IVW analysis, we found that genetic susceptibility to AS was associated with an increased risk of leukemia (OR = 1.002; 95%CI, 1.001–1.003; p = 0.003) and an increased risk of lymphocytic leukemia [OR = 1.001; 95% CI, (1.000–1.002), p = 0.008]. There was no evidence that AS was associated with lymphoma, myeloid leukemia, and MM.ConclusionOur research indicates that AS was associated with an elevated risk of leukemia, and further analysis of specific types of leukemia showed that the risk of lymphocytic leukemia was associated with AS. Our findings highlight the importance of active intervention and monitoring to mitigate leukemia, especially lymphocytic leukemia risk in patients with AS.
The effect of curcumax on postpartum women’s depression: a randomized controlled trial
Authors: Nikpour Fatemeh , Ansari Somayeh , Abedi Parvin , Jahanfar Shayesteh , Sharifat Naeim , Hooshmand Gholamreza , Maraghi Elham 
Published: September 2024

BackgroundPostpartum depression is a major psychiatric disorder that affects the mother-baby attachment and may impair cognitive development of the child.ObjectiveThis study aimed to evaluate the effect of curcumax (including ginger, turmeric, and black pepper) on postpartum depression in reproductive-aged women.Material and methodsThis was a randomized controlled trial in which 124 women were recruited and randomly assigned into two groups of curcumax (n=62) and placebo (n=62) who consumed curcumax or placebo for 8 weeks (one capsule each day). Postpartum depression was measured using Edinburgh Depression Scale. Data were analyzed using Chi-square, independent t-test, and GEE.ResultsThe mean (SD) score of depression score was 15.83 (2.77) and 15.45 (2.97) before intervention, which reduced to 3.48 (4.29) and 7.22 (3.98) in the intervention and control groups, respectively after 4 weeks (p&lt;0.0001). After eight weeks of intervention, these scores reduced to 1.72 (3.30) and 5.85 (3.67) in the intervention and control groups, respectively (p&lt;0.0001).ConclusionThe results of this study showed that curcumax significantly reduced the mean score of postpartum depression among reproductive-aged women. Because it is the first time this herb was used as an anti-depressant, its effective dose was not available. Therefore, further studies with higher doses of this herb are recommended.Clinical Trial Registrationhttps://irct.behdasht.gov.ir/search/result?query=IRCT20210822052254N1, identifier IRCT20210822052254N1.
Intersectional equity in Brazil’s remote rural municipalities: the road to efficiency and effectiveness in local health systems
Authors: Schenkman Simone , Bousquat Aylene 
Published: September 2024

ObjectiveThe Brazilian remote rurality has been classified more reliably only recently, according to demographic density, proportion of urban population, and accessibility to urban centers. It comprises 5.8% of the municipalities, in nearly half of the states, with a population of 3,524,597 (1.85%). Remote rural localities (RRL) have reduced political/economic power, facing greater distances and barriers. Most health strategies are developed with the urban space in mind. We aim to understand how RRL are positioned concerning efficiency/effectiveness in health, compared to other urban-rural typologies of Brazilian localities, focusing on Primary Health Care (PHC), and its organizational models.MethodsWe evaluated the efficiency and effectiveness of the organizational models using the health production model, from 2010–2019, gradually deepening the immersion into the RRL reality. We analyzed the human and financial resources dimensions, emphasizing teams, the results of PHC actions, and health levels. We used the fixed effects model and data envelopment analysis, cross-sectioned by intersectional inequities. We compared the Brazilian states with and without RRL, Brazilian municipalities according to rural-urban typologies, and RRL clusters.ResultsBrazilian RRL states show superior resource/health efficiency through services utilization according to health needs. The remote rural typology demonstrated greater efficiency and effectiveness in health than the other typologies in the RRL states. The organizational models with the Family Health Strategy (FHS) teams and the Community Health Worker (CHW) visits played a key role, together with local per capita health expenditures and intergovernmental transfers. Thus, financial resources and health professionals are essential to achieve efficient/effective results in health services. Among the RRL, the Amazon region clusters stand out, denoting the importance of riverine and fluvial health teams, the proportion of diagnostic/treatment units in addition to the proportion of illiteracy and adolescent mothers along with the inequity of reaching high levels of schooling between gender/ethnicity.ConclusionHopefully, these elements might contribute to gains in efficiency and effectiveness, prioritizing the allocation of financial/human resources, mobile FHS teams, availability of local diagnosis/treatment, and basic sanitation. Finally, one should aim for equity of gender/ethnicity in income and education and, above all, of place, perceived in its entirety.
Tracking multidrug resistant tuberculosis: a 30-year analysis of global, regional, and national trends
Authors: Song Hui-Wen , Tian Jian-Hua , Song Hui-Ping , Guo Si-Jie , Lin Ye-Hong , Pan Jin-Shui 
Published: September 2024

ObjectivesTo provide valuable insights for targeted interventions and resource allocation, our analysis delved into the multifaceted burden, trends, risks, and projections of multi drug resistant tuberculosis (MDR-TB).MethodsThis research employed data from the Global Burden of Disease (GBD) 2019 dataset, which used a comparative risk assessment to quantify the disease burden resulting from risk factors. Initially, this database was utilized to extract details concerning the disability-adjusted life years (DALYs), mortality, incidence, and the number of individuals afflicted by MDR-TB. Subsequently, regression analyses were conducted using the Joinpoint program to figure average annual percent change (AAPC) to ascertain the trend. Thirdly, the age-period-cohort model (APCM) was adopted to analyze evolutions in incidence and mortality. Finally, utilizing the Nordpred model within R software, we projected the incidence and mortality of MDR-TB from 2020 to 2030.ResultsMDR-TB remained a pressing global health concern in regions with lower socio-demographic indexes (SDI), where the AAPC in DALYs topped 7% from 1990 to 2019. In 2019, the cumulative DALYs attributed to MDR-TB tallied up to 4.2 million, with India, the Russian Federation, and China bearing the brunt. Notably, the incidence rates have shown a steadfast presence over the past decade, and a troubling forecast predicts an uptick in these areas from 2020 to 2030. Additionally, the risk of contracting MDR-TB grew with advancing age, manifesting most acutely among men aged 40+ in lower SDI regions. Strikingly, alcohol consumption had been identified as a significant contributor, surpassing the impacts of smoking and high fasting plasma glucose, leading to 0.7 million DALYs in 2019.ConclusionsA robust strategy is needed to end tuberculosis (TB) by 2030, especially in lower SDI areas.