bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction forces between microfluidic droplets in a Hele-Shaw cell
Authors: Sarig I. , Starosvetsky Y. , Gat A. D. 
Published: July 2016

Various microfluidic systems, such as chemical and biological lab-on-a-chip devices, involve motion of multiple droplets within an immersing fluid in shallow microchannels. Modelling the dynamics of such systems requires calculation of the forces of interaction between the moving droplets. These forces are commonly approximated by superposition of dipole solutions, which requires an assumption of sufficiently large distance between the droplets. In this work we obtain exact solutions (in the Hele-Shaw limit) for two moving droplets, and a droplet within a droplet, located within a moving immersing fluid, without limitation on the distance between the droplets. This is achieved by solution of the pressure field in a bipolar coordinate system and calculation of the force in Cartesian coordinates. Our results are compared with numerical computations, experimental data and the existing dipole-based models. We utilize the results to calculate the dynamics of a droplet within a droplet, and of two close droplets, located within an immersing fluid with oscillating speed. Overall, the obtained results establish the solid base for the rather important future extensions for modelling the complex, long-range interdroplet interactions in the limit of dense droplet media.
Molecular Line Emission Towards High-Mass Clumps: The MALT90 Catalogue
Authors: Rathborne J. M. , Whitaker J. S. , Jackson J. M. , Foster J. B. , Contreras Y. , Stephens I. W. , Guzmán A. E. , Longmore S. N. , Sanhueza P. , Schuller F. , Wyrowski F. , Urquhart J. S. 
Published: July 2016

AbstractThe Millimetre Astronomy Legacy Team 90 GHz survey aims to characterise the physical and chemical evolution of high-mass clumps. Recently completed, it mapped 90 GHz line emission towards 3 246 high-mass clumps identified from the ATLASGAL 870 μm Galactic plane survey. By utilising the broad frequency coverage of the Mopra telescope’s spectrometer, maps in 16 different emission lines were simultaneously obtained. Here, we describe the first catalogue of the detected line emission, generated by Gaussian profile fitting to spectra extracted towards each clumps’ 870 μm dust continuum peak. Synthetic spectra show that the catalogue has a completeness of > 95%, a probability of a false-positive detection of < 0.3%, and a relative uncertainty in the measured quantities of < 20% over the range of detection criteria. The detection rates are highest for the (1–0) transitions of HCO+, HNC, N2H+, and HCN (~77–89%). Almost all clumps (~95%) are detected in at least one of the molecular transitions, just over half of the clumps (~53%) are detected in four or more of the transitions, while only one clump is detected in 13 transitions. We find several striking trends in the ensemble of properties for the different molecular transitions when plotted as a function of the clumps’ evolutionary state as estimated from Spitzer mid-IR images, including (1) HNC is relatively brighter in colder, less evolved clumps than those that show active star formation, (2) N2H+ is relatively brighter in the earlier stages, (3) that the observed optical depth decreases as the clumps evolve, and (4) the optically thickest HCO+ emission shows a ‘blue-red asymmetry’ indicating overall collapse that monotonically decreases as the clumps evolve. This catalogue represents the largest compiled database of line emission towards high-mass clumps and is a valuable data set for detailed studies of these objects.
Temporal and Spatial Variations of Freshwater Reservoir Ages in the Loire River Watershed
Authors: Coularis C , Tisnérat-Laborde N , Pastor L , Siclet F , Fontugne M 
Published: July 2016

AbstractIn order to map the freshwater reservoir effect (FRE) variability of the Loire River and its tributaries, spatial and temporal carbon isotope (13C and 14C) analyses of the dissolved inorganic carbon (DIC) were conducted. Sites were selected to represent the diversity of geological settings, soil type, and land use. Results show a large spatial variability of 14C FRE ranging between 135 and 2251±30 yr, objectively correlated to DIC contents and alkalinity. Deeper investigations of the relationship between 14C activity of DIC and environmental variables show that the geological substrate is the dominant factor in the 14C reservoir effect, and far more influential than the river flow discharge.
High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial
Authors: Hagen Ingrid V. , Helland Anita , Bratlie Marianne , Brokstad Karl A. , Rosenlund Grethe , Sveier Harald , Mellgren Gunnar , Gudbrandsen Oddrun A. 
Published: July 2016

AbstractThe aim of the present study was to examine whether high intake of lean or fatty fish (cod and farmed salmon, respectively) by healthy, normal-weight adults would affect risk factors of type 2 diabetes and CVD when compared with lean meat (chicken). More knowledge is needed concerning the potential health effects of high fish intake (>300 g/week) in normal-weight adults. In this randomised clinical trial, thirty-eight young, healthy, normal-weight participants consumed 750 g/week of lean or fatty fish or lean meat (as control) for 4 weeks at dinner according to provided recipes to ensure similar ways of preparations and choices of side dishes between the groups. Energy and macronutrient intakes at baseline and end point were similar in all groups, and there were no changes in energy and macronutrient intakes within any of the groups during the course of the study. High intake of fatty fish, but not lean fish, significantly reduced TAG and increased HDL-cholesterol concentrations in fasting serum when compared with lean meat intake. When compared with lean fish intake, fatty fish intake increased serum HDL-cholesterol. No differences were observed between lean fish, fatty fish and lean meat groups regarding fasting and postprandial glucose regulation. These findings suggest that high intake of fatty fish, but not of lean fish, could beneficially affect serum concentrations of TAG and HDL-cholesterol, which are CVD risk factors, in healthy, normal-weight adults, when compared with high intake of lean meat.
Asian snake farms: conservation curse or sustainable enterprise?
Authors: Aust Patrick W. , Van Tri Ngo , Natusch Daniel J.D. , Alexander Graham J. 
Published: July 2016

AbstractSnake farming in Asia has increased over the past decade, and conservationists have expressed concerns that farms may foster overexploitation of wild populations and create legal conduits for illegally harvested wild individuals. We conducted face-to-face interviews with snake farmers in Viet Nam and China, with the aim of describing the basic models under which snakes are farmed for meat. We synthesized this information to assess the feasibility of farming snakes for human consumption, drawing conclusions about the impact of this industry on the conservation of wild snake populations. The most commonly farmed snakes include the monocled cobraNaja kaouthia, the Chinese cobraNaja atra, the oriental rat snakePtyas mucosusand the king cobraOphiophagus hannah. These species have life histories that are compatible with the demands of intensive livestock production, including early maturity, rapid growth rates, high reproductive output, efficient food assimilation rates and undemanding space requirements. Snake farmers appear to be capitalizing on the unique energy-efficiency of snakes to produce meat for human consumption. We conclude that the ease and profitability of farming snakes in China and Viet Nam make farming a viable substitute for harvesting wild snakes, with apparently minimal threat to wild populations. Snake farming offers a range of novel agricultural opportunities and has the potential to play a pivotal role in sustainable development.
Are orthographic effects language specific? The influence of second language orthography on second language phoneme awareness
Authors: PYTLYK CAROLYN 
Published: July 2016

ABSTRACTThis research investigated first language (L1) and second language (L2) orthographic effects on L2 phoneme perception. Twenty-five native English learners of Russian (n = 13) and Mandarin (n = 12) participated in an auditory phoneme counting task, using stimuli organized along two parameters: consistency and homophony. The learners more successfully counted phonemes in L2 words with consistent letter–phoneme correspondences (e.g., всё /fsʲɔ/, three letters/three phonemes) than in words with inconsistent correspondences (e.g., звать /zvatʲ/, five letters/four phonemes), indicating that L2 phoneme awareness is influenced by L2 orthography and that orthographic effects are not limited to the L1. In addition, the lack of any L1 homophone effects suggests that L2 orthographic effects overrode any potential L1 orthographic interference for these intermediate-level learners, suggesting orthographic effects may be language specific.
Children who stutter exchange linguistic accuracy for processing speed in sentence comprehension
Authors: FORTUNATO-TAVARES TALITA , HOWELL PETER , SCHWARTZ RICHARD G. , DE ANDRADE CLAUDIA R. FURQUIM 
Published: July 2016

ABSTRACTComprehension of predicates and reflexives was examined in children who stutter (CWS) and children who do not stutter (CWNS) who were between 9 years, 7 months and 10 years, 2 months. Demands on working memory and manual reaction time were also assessed in two experiments that employed a four-choice picture-selection sentence comprehension task. CWS were less accurate than CWNS on the attachment of predicates. For reflexives, there was no between-group difference in accuracy, but there was a difference in speed. The two constructions induced processing at different points on a speed–accuracy continuum with CWS sacrificing accuracy to respond fast with predicates, while they maintained accuracy of reflexives by responding slower relative to CWNS. Predicates made more demands on language than nonspeech motor reaction time, whereas the reverse was the case with reflexives for CWS compared to CWNS.
Nodal vector solutions with clustered peaks for nonlinear elliptic equations in ℝ3
Authors: He Qihan , Wang Chunhua 
Published: July 2016

We study the following coupled nonlinear Schr¨odinger system in ℝ3:where μ1 > 0, μ2 > 0 and β ∈ ℝ is a coupling constant. Irrespective of whether the system is repulsive or attractive, we prove that it has nodal semi-classical segregated or synchronized bound states with clustered spikes for sufficiently small ε under some additional conditions on P(x), Q(x) and β. Moreover, the number of this type of solutions will go to infinity as ε → 0+.
Faith and the Free Market: Evangelicals, the Tea Party, and Economic Attitudes
Authors: Deckman Melissa , Cox Dan , Jones Robert , Cooper Betsy 
Published: July 2016

AbstractWe argue that concerted efforts by Tea Party leaders, Republican politicians, and leading Christian Right figures to establish and promote a connection between Christian faith and the free-market system has helped shift the economic attitudes of white evangelical Protestants in a more conservative direction. Our analysis of Public Religion Research Institute survey data finds that white evangelical Protestants express greater skepticism about an active role of government in society and believe economic growth is more likely to be spurred by a reduction in taxes rather than in public investments. Moreover, we find that identifying with the Tea Party has a conservatizing influence on their economic issue positions. While we find that partisanship, class, and in some cases, age, serve to modify the views of some evangelicals, by and large, evangelicals have come to embrace the conservative fiscal message promoted by both the Republican Party and the Tea Party movement.
Controllable optical activity with non-chiral plasmonic metasurfaces
Authors: Yu Ping , Li Jianxiong , Tang Chengchun , Cheng Hua , Liu Zhaocheng , Li Zhancheng , Liu Zhe , Gu Changzhi , Li Junjie , Chen Shuqi , Tian Jianguo 
Published: July 2016

AbstractOptical activity is the rotation of the plane of linearly polarized light along the propagation direction as the light travels through optically active materials. In existing methods, the strength of the optical activity is determined by the chirality of the materials, which is difficult to control quantitatively. Here we numerically and experimentally investigated an alternative approach to realize and control the optical activity with non-chiral plasmonic metasurfaces. Through judicious design of the structural units of the metasurfaces, the right and left circular polarization components of the linearly polarized light have different phase retardations after transmitting through the metasurfaces, leading to large optical activity. Moreover, the strength of the optical activity can be easily and accurately tuned by directly adjusting the phase difference. The proposed approach based on non-chiral plasmonic metasurfaces exhibits large optical activity with a high controllable degree of freedom, which may provide more possibilities for applications in photonics.
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Authors: Mitchell Jonathan S. , Li Ni , Weinhold Niels , Försti Asta , Ali Mina , van Duin Mark , Thorleifsson Gudmar , Johnson David C. , Chen Bowang , Halvarsson Britt-Marie , Gudbjartsson Daniel F. , Kuiper Rowan , Stephens Owen W. , Bertsch Uta , Broderick Peter , Campo Chiara , Einsele Hermann , Gregory Walter A. , Gullberg Urban , Henrion Marc , Hillengass Jens , Hoffmann Per , Jackson Graham H. , Johnsson Ellinor , Jöud Magnus , Kristinsson Sigurður Y. , Lenhoff Stig , Lenive Oleg , Mellqvist Ulf-Henrik , Migliorini Gabriele , Nahi Hareth , Nelander Sven , Nickel Jolanta , Nöthen Markus M. , Rafnar Thorunn , Ross Fiona M. , da Silva Filho Miguel Inacio , Swaminathan Bhairavi , Thomsen Hauke , Turesson Ingemar , Vangsted Annette , Vogel Ulla , Waage Anders , Walker Brian A. , Wihlborg Anna-Karin , Broyl Annemiek , Davies Faith E. , Thorsteinsdottir Unnur , Langer Christian , Hansson Markus , Kaiser Martin , Sonneveld Pieter , Stefansson Kari , Morgan Gareth J. , Goldschmidt Hartmut , Hemminki Kari , Nilsson Björn , Houlston Richard S. 
Published: July 2016

AbstractMultiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10−8), 6q21 (rs9372120, P=9.09 × 10−15), 7q36.1 (rs7781265, P=9.71 × 10−9), 8q24.21 (rs1948915, P=4.20 × 10−11), 9p21.3 (rs2811710, P=1.72 × 10−13), 10p12.1 (rs2790457, P=1.77 × 10−8), 16q23.1 (rs7193541, P=5.00 × 10−12) and 20q13.13 (rs6066835, P=1.36 × 10−13), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
Postoperative autotransfusion drain after total hip arthroplasty: a meta-analysis of randomized controlled trials
Authors: Xie Hui , Pan Jian-Ke , Hong Kun-Hao , Guo Da , Fang Jian , Yang Wei-Yi , Liu Jun 
Published: July 2016

AbstractThe use of a postoperative autotransfusion drain (PATD) to reduce allogenic blood transfusions in total hip arthroplasty (THA) remains controversial. Therefore, we conducted a meta-analysis to evaluate the efficacy and safety of this technique. Randomized controlled trials (RCTs) were identified from PubMed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL). Thirteen RCTs (1,424 participants) were included in our meta-analysis. The results showed that PATD reduced the rate of allogenic transfusions (RR = 0.56; 95% CI [0.40, 0.77]) and total blood loss (MD = −196.04; 95% CI [−311.01, −81.07]). Haemoglobin (Hb) levels were higher in the PATD group on postoperative day 1 (MD = 0.28; 95% CI [0.06, 0.49]), but no significant differences on postoperative days 2 or 3 (MD = 0.29; 95% CI [−0.02, 0.60]; MD = 0.26; 95% CI [−0.04, 0.56]; respectively). There were no differences in length of hospital stay (MD = −0.18; 95% CI [−0.61, 0.25]), febrile reaction (RR = 1.26; 95% CI [0.95, 1.67]), infection (RR = 0.95; 95% CI [0.54, 1.65]), wound problems (RR = 1.07; 95% CI [0.87, 1.33]), or serious adverse events (RR = 0.59; 95% CI [0.10, 3.58]). Our findings suggest that PATD is effective in reducing the rate of allogenic transfusion. However, the included studies are inadequately powered to conclusively determine the safety of this technique.
Prognostic values of four Notch receptor mRNA expression in gastric cancer
Authors: Wu Xiaoyu , Liu Wentao , Tang Ding , Xiao Haijuan , Wu Zhenfeng , Chen Che , Yao Xuequan , Liu Fukun , Li Gang 
Published: July 2016

AbstractNotch ligands and receptors are frequently deregulated in several human malignancies including gastric cancer. The activation of Notch signaling has been reported to contribute to gastric carcinogenesis and progression. However, the prognostic roles of individual Notch receptors in gastric cancer patients remain elusive. In the current study, we accessed the prognostic roles of four Notch receptors, Notch 1–4, in gastric cancer patients through “The Kaplan-Meier plotter” (KM plotter) database, in which updated gene expression data and survival information include a total of 876 gastric cancer patients. All four Notch receptors’ high mRNA expression was found to be correlated to worsen overall survival (OS) for all gastric cancer patients followed for 20 years. We further accessed the prognostic roles of individual Notch receptors in different clinicopathological features using Lauren classification, pathological grades, clinical grades, HER2 status and different choices of treatments of gastric cancer patients. These results indicate that there are critical prognostic values of the four Notch receptors in gastric cancer. This information will be useful for better understanding of the heterogeneity and complexity in the molecular biology of gastric cancer and to develop tools to more accurately predict their prognosis.
Indexing Effects of Copy Number Variation on Genes Involved in Developmental Delay
Authors: Uddin Mohammed , Pellecchia Giovanna , Thiruvahindrapuram Bhooma , D’Abate Lia , Merico Daniele , Chan Ada , Zarrei Mehdi , Tammimies Kristiina , Walker Susan , Gazzellone Matthew J. , Nalpathamkalam Thomas , Yuen Ryan K. C. , Devriendt Koenraad , Mathonnet Géraldine , Lemyre Emmanuelle , Nizard Sonia , Shago Mary , Joseph-George Ann M. , Noor Abdul , Carter Melissa T. , Yoon Grace , Kannu Peter , Tihy Frédérique , Thorland Erik C. , Marshall Christian R. , Buchanan Janet A. , Speevak Marsha , Stavropoulos Dimitri J. , Scherer Stephen W. 
Published: July 2016

AbstractA challenge in clinical genomics is to predict whether copy number variation (CNV) affecting a gene or multiple genes will manifest as disease. Increasing recognition of gene dosage effects in neurodevelopmental disorders prompted us to develop a computational approach based on critical-exon (highly expressed in brain, highly conserved) examination for potential etiologic effects. Using a large CNV dataset, our updated analyses revealed significant (P < 1.64 × 10−15) enrichment of critical-exons within rare CNVs in cases compared to controls. Separately, we used a weighted gene co-expression network analysis (WGCNA) to construct an unbiased protein module from prenatal and adult tissues and found it significantly enriched for critical exons in prenatal (P < 1.15 × 10−50, OR = 2.11) and adult (P < 6.03 × 10−18, OR = 1.55) tissues. WGCNA yielded 1,206 proteins for which we prioritized the corresponding genes as likely to have a role in neurodevelopmental disorders. We compared the gene lists obtained from critical-exon and WGCNA analysis and found 438 candidate genes associated with CNVs annotated as pathogenic, or as variants of uncertain significance (VOUS), from among 10,619 developmental delay cases. We identified genes containing CNVs previously considered to be VOUS to be new candidate genes for neurodevelopmental disorders (GIT1, MVB12B and PPP1R9A) demonstrating the utility of this strategy to index the clinical effects of CNVs.
A five years study of antiviral effect of entecavir in Chinese chronic hepatitis B patients
Authors: Liu Kehui , Xiang Xiaogang , Bao Rebecca , Chen Rong , Liu Yunye , Xie Jingdong , Guo Qing , Bao Shisan , Xie Qing , Wang Hui 
Published: July 2016

AbstractEntecavir (ETV) is a potent viral replication inhibitor for chronic hepatitis B (CHB) patients. To investigate the efficacy of ETV in Chinese nucleos(t)ide(NA)-experienced CHB patients. Among 89 CHB patients with ETV monotherapy for ≥6 months, 33/89 (37%) or 56/89 (73%) were NA-naïve or NA-experienced. During a median follow-up of 5.75 years, all NA-naïve CHB patients achieved VR without genotypic ETV-resistance. However, VR was observed in 50/56 (~90%) of NA-experienced CHB patients during a median follow-up of 4.75 years. Antiviral efficacy was not reduced in patients with previous lamivudine (LAM) with/without LAM-resistance (HR 0.465; 95% CI 0.196–1.100; p > 0.05) (HR 0.472; 95% CI 0.205–1.091; p > 0.05). Patients with a primary treatment failure to adefovir (ADV) had a reduced probability of achieving VR compared to NA-naïve (HR 0.496; 95% CI 0.287–0.857; p < 0.01). Previous ADV-experienced patients with a partial VR (HR 1.253; 95% CI 0.429–3.665; p > 0.05) did not influence antiviral response to ETV. The antiviral efficacy of ETV is not influenced by previous treatment LAM with/without LAM-resistance. ETV may still be an option in ADV-experienced patients with a partial VR, but not advised in patients with a primary treatment failure to ADV.
The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
Authors: Aliota Matthew T. , Peinado Stephen A. , Velez Ivan Dario , Osorio Jorge E. 
Published: July 2016

AbstractZika virus (ZIKV) is causing an explosive outbreak of febrile disease in the Americas. There are no effective antiviral therapies or licensed vaccines for this virus and mosquito control strategies have not been adequate to contain the virus. A promising candidate for arbovirus control and prevention relies on the introduction of the intracellular bacterium Wolbachia into Aedes aegypti mosquitoes. This primarily has been proposed as a tool to control dengue virus (DENV) transmission; however, evidence suggests Wolbachia infections confer protection for Ae. aegypti against other arboviruses. At present, it is unknown whether or not ZIKV can infect, disseminate and be transmitted by Wolbachia-infected Ae. aegypti. Using Ae. aegypti infected with the wMel strain of Wolbachia that are being released in Medellin, Colombia, we report that these mosquitoes have reduced vector competence for ZIKV. These results support the use of Wolbachia biocontrol as a multivalent strategy against Ae. aegypti-transmitted viruses.