bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encapsulation of lemongrass oil with cyclodextrins by spray drying and its controlled release characteristics
Authors: Phunpee Sarunya , Ruktanonchai Uracha Rangsadthong , Yoshii Hidefumi , Assabumrungrat Suttichai , Soottitantawat Apinan 
Published: January 2017

Abstract
Inclusion of the two isomers of citral (E-citral and Z-citral), components of lemongrass oil, was investigated within the confines of various cyclodextrin (α-CD, β-CD and γ-CD) host molecules. Aqueous complex formation constants for E-citral with α-CD, β-CD and γ-CD were determined to be 123, 185, and 204 L/mol, respectively, whereas Z-citral exhibited stronger affinities (157, 206, and 253 L/mol, respectively). The binding trend γ-CD &gt; β-CD &gt; α-CD is a reflection of the more favorable geometrical accommodation of the citral isomers with increasing cavity size. Encapsulation of lemongrass oil within CDs was undertaken through shaking citral:CD (1:1, 1.5:1, and 2:1 molar ratio) mixtures followed by spray drying. Maximum citral retention occurred at a 1:1 molar ratio with β-CD and α-CD demonstrating the highest levels of total E-citral and Z-citral retention, respectively. Furthermore, the β-CD complex demonstrated the slowest release rate of all inclusion complex powders.
DeuteRater: a tool for quantifying peptide isotope precision and kinetic proteomics
Authors: Naylor Bradley C , Porter Michael T , Wilson Elise , Herring Adam , Lofthouse Spencer , Hannemann Austin , Piccolo Stephen R , Rockwood Alan L , Price John C 
Published: January 2017

Abstract

Motivation
Using mass spectrometry to measure the concentration and turnover of the individual proteins in a proteome, enables the calculation of individual synthesis and degradation rates for each protein. Software to analyze concentration is readily available, but software to analyze turnover is lacking. Data analysis workflows typically don’t access the full breadth of information about instrument precision and accuracy that is present in each peptide isotopic envelope measurement. This method utilizes both isotope distribution and changes in neutromer spacing, which benefits the analysis of both concentration and turnover.

Results
We have developed a data analysis tool, DeuteRater, to measure protein turnover from metabolic D2O labeling. DeuteRater uses theoretical predictions for label-dependent change in isotope abundance and inter-peak (neutromer) spacing within the isotope envelope to calculate protein turnover rate. We have also used these metrics to evaluate the accuracy and precision of peptide measurements and thereby determined the optimal data acquisition parameters of different instruments, as well as the effect of data processing steps. We show that these combined measurements can be used to remove noise and increase confidence in the protein turnover measurement for each protein.

Availability and Implementation
Source code and ReadMe for Python 2 and 3 versions of DeuteRater are available at https://github.com/JC-Price/DeuteRater. Data is at https://chorusproject.org/pages/index.html project number 1147. Critical Intermediate calculation files provided as Tables S3 and S4. Software has only been tested on Windows machines.

Supplementary information
Supplementary data are available at Bioinformatics online.
Survey on current practice within the European Low-Grade Glioma Network: where do we stand and what is the next step?
Authors: Mandonnet Emmanuel , Wager Michel , Almairac Fabien , Baron Marie-Helene , Blonski Marie , Freyschlag Christian F , Barone Fabio , Fontaine Denys , Pallud Johan , Hegi Monika , Viegas Catarina , Zetterling Maria , Spena Giannantonio , Goodden John , Rutten Geert-Jan , Taillandier Luc , Foroglu Nicolas , Darlix Amélie , Skrap Miran , Martino Juan , von Campe Gord , Madadaki Caterina , Gayat Etienne , de Witt Hamer Philip , Gil Robles Santiago , Sarubbo Silvio , Santorius Thomas , Bello Lorenzo , Forster Marie-Therese , Duffau Hugues 
Published: January 2017

Abstract
Diffuse low-grade glioma form a rare entity affecting young people. Despite advances in surgery, chemotherapy, and radiation therapy, diffuse low-grade glioma are still incurable. According to current guidelines, maximum safe resection, when feasible, is the first line of treatment. Apart from surgery, all other treatment modalities (temozolomide, procarbazine-CCNU-vincristine regimen, and radiation therapy) are handled very differently among different teams, and this in spite of recent results of several phase 3 studies. Based on a European survey, this paper aimed to get a picture of this heterogeneity in diffuse low-grade glioma management, to identify clinically relevant questions raised by this heterogeneity of practice, and to propose new methodological frameworks to address these questions.
Trabecular Microstructure and Damage Affect Cement Leakage From the Basivertebral Foramen During Vertebral Augmentation
Authors: Li Shengyun , Wang Chongyan , Shan Zhi , Liu Junhui , Yu Tianming , Zhang Xuyang , Fan Shunwu , Christiansen Blaine A. , Ding Wenyuan , Zhao Fengdong 
Published: January 2017

Study design.
A prospective study on cadaver specimens.

Objective.
To explore why cement leakage from basivertebral foramen (BF) easily occurs during vertebral augmentation procedures.

Summary of Background Data.
Type B (through BF, basivertebral foramen) cement leakage is the most common type after vertebral augmentation, but the mechanism of this is still controversial. The contribution of vertebral trabecular bone orientation and trabecular damage during compression fracture to cement leakage is still unknown.

Methods.
In this study, 12 fresh-frozen human lumbar spines (T12-L5) were collected and divided into 24 three-segment units. Mechanical testing was performed to simulate a compression fracture. MicroCT were performed on all segments before and after mechanical testing, and trabecular microstructure of the superior, middle (containing BF), and inferior 1/3 of each vertebral body was analyzed. The diameter variation of intertrabecular space before and after compression fracture was used to quantify trabecular injury. After mechanical testing, vertebral augmentation, and imaging-based diagnosis were used to evaluate cement leakage.

Results.
Trabecular bone microstructural parameters in middle region (containing BF) were lower than those of the superior or inferior regions (P < 0.01). After compressive failure, 3D-reconstruction of the vertebral body by MicroCT demonstrated that intertrabecular distance in the middle region was markedly increased. Type B cement leakage was the most common type after vertebral augmentation, as found previously in Wang et al. (Spine J 2014;14: 1551-1558).

Conclusion.
The presence of the BF and the relative sparsity of trabecular bone make the middle region of the vertebral body the mechanically weakest region. Trabecular bone in middle region suffered the most severe damage during compressive failure of the vertebral body, which resulted in the greatest intervertebral spacing, and subsequently the highest percentage of type B cement leakage. These data suggest specific mechanisms by which cement may leak from the BF, and the contribution of trabecular microstructure and trabecular injury.

Level of Evidence: 4
Does Familial Aggregation of Chronic Low Back Pain Affect Recovery?
Authors: Zadro Joshua R. , Shirley Debra , Sánchez-Romera Juan F. , Ordoñana Juan R. , Ferreira Paulo H. 
Published: January 2017

Study Design.
Longitudinal twin-cohort study.

Objective.
To investigate the effect familial aggregation of chronic low back pain (LBP) has on the recovery from chronic LBP.

Summary of Background Data.
LBP is a worldwide problem, with pain and disability often becoming chronic. Genetics and familial behaviors could significantly affect the recovery from chronic LBP but have not been extensively investigated.

Methods.
A total of 624 Spanish twins from the Murcia Twin Registry reported experiencing chronic LBP within the past 2 years during the 2009/11 data collection wave and were followed up in 2013. Familial aggregation of chronic LBP was determined by the co-twin experiencing chronic LBP within the past 2 years at baseline. Twins reporting LBP “within the past 4 weeks” at follow-up were considered to have not recovered.

Results.
There were 455 twins with available data on LBP at follow-up and available data on LBP from their co-twin at baseline. Twins with an affected co-twin at baseline were significantly more likely to have not recovered from chronic LBP at follow-up (odds ratio [OR] = 1.6, 95% confidence interval [CI]: 1.0–2.4, P = 0.046). This relationship was stronger for monozygotic twins (OR = 2.5, 95% CI: 1.3–4.8, P = 0.006) (n = 172) but disappeared when considering only dizygotic twins (OR = 1.1, 95% CI: 0.6–2.0, P = 0.668) (n = 283). Sibling-relative recurrence risk (λ
s) was 1.2 for the total sample, 1.5 for monozygotic twins, and 1.1 for dizygotic twins.

Conclusion.
Having a sibling with chronic LBP at baseline increased the likelihood of LBP at follow-up by 20%, with this likelihood increasing to 50% if the sibling was an identical twin. These results are novel and highlight the important influence genetics have on people's recovery from chronic LBP. Information regarding the presence of chronic LBP within a family is easy to obtain and has the potential to inform clinicians on which patients are less likely to recover when treatment implementation is not considered.

Level of Evidence: 3
STELLATE NONHEREDITARY IDIOPATHIC FOVEOMACULAR RETINOSCHISIS ACCOMPANIED BY CONTRALATERAL PERIPHERAL RETINOSCHISIS
Authors: Ahmed Daniel , Stattin Martin , Glittenberg Carl , Krebs Ilse , Ansari-Shahrezaei Siamak 
Published: January 2017

Purpose:
To present a patient with stellate nonhereditary idiopathic foveomacular retinoschisis on one eye and peripheral retinoschisis without foveal affection on the other eye.

Methods:
A case report with complete workup of family history and clinical examination, including multimodal imaging with optical coherence tomography and angiography, fluorescein angiography, and infrared fundus imaging. Genetic testing for gene mutation XRLS1 was performed.

Results:
A white woman with unremarkable medical history presented with stellate foveal splitting of the outer plexiform layer on the right eye and peripheral splitting of the outer plexiform layer on both eyes. All known allegeable trigger factors for the existence of a hereditary or acquired foveomacular retinoschisis were ruled out either by clinical presentation or genetic testing. This led to the diagnosis of stellate nonhereditary idiopathic foveomacular retinoschisis with central involvement only present on one eye.

Conclusion:
Although peripheral schisis of the outer plexiform layer is often concomitant with central splitting in X-linked juvenile retinoschisis, this is the first known report of nonhereditary cleavage of the outer plexiform layer of the peripheral retina without central affection in a patient with documented stellate nonhereditary idiopathic foveomacular retinoschisis on the other eye. These findings suggest an accurate bilateral examination of the peripheral retina while confirming the diagnose of stellate nonhereditary idiopathic foveomacular retinoschisis.
A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases
Authors: Ducancelle Alexandra , Leroy Vincent , Vergniol Julien , Sturm Nathalie , Le Bail Brigitte , Zarski Jean Pierre , Nguyen Khac Eric , Salmon Dominique , de Ledinghen Victor , Calès Paul 
Published: January 2017

Background and Goal:
International guidelines suggest combining a blood test and liver stiffness measurement (LSM) to stage liver fibrosis in chronic hepatitis C (CHC) and non–alcoholic fatty liver disease (NAFLD). Therefore, we compared the accuracies of these tests between the main etiologies of chronic liver diseases.

Study:
Overall, 1968 patients were included in 5 etiologies: CHC: 698, chronic hepatitis B: 152, human immunodeficiency virus/CHC: 628, NAFLD: 225, and alcoholic liver disease (ALD): 265. Sixteen tests [13 blood tests, LSM (Fibroscan), 2 combined: FibroMetersVCTE] were evaluated. References were Metavir staging and CHC etiology. Accuracy was evaluated mainly with the Obuchowski index (OI) and accessorily with area under the receiver operating characteristics (F≥2, F≥3, cirrhosis).

Results:
OIs in CHC were: FibroMetersVCTE: 0.812, FibroMetersV: 0.785 to 0.797, Fibrotest: 0.762, CirrhoMetersV: 0.756 to 0.771, LSM: 0.754, Hepascore: 0.752, FibroMeterALD: 0.750, aspartate aminotransferase platelet ratio index: 0.742, Fib-4: 0.741. In other etiologies, most tests had nonsignificant changes in OIs. In NAFLD, CHC-specific tests were more accurate than NAFLD-specific tests. The combined FibroMetersVCTE had significantly higher accuracy than their 2 constitutive tests (FibroMetersV and LSM) in at least 1 diagnostic target in all etiologies, except in ALD where LSM had the highest OI, and in 3 diagnostic targets (OIs and 2 area under the receiver operating characteristics) in CHC and NAFLD.

Conclusions:
Some tests developed in CHC outperformed other tests in their specific etiologies. Tests combining blood markers and LSM outperformed single tests, validating recent guidelines and extending them to main etiologies. Noninvasive fibrosis evaluation can thus be simplified in the main etiologies by using a unique test: either LSM alone, especially in ALD, or preferably combined to blood markers.
Crohn’s Disease
Authors: Schöffel Norman , Brüggmann Dörthe , Klingelhöfer Doris , Bendels Michael H.K. , Groneberg David A. 
Published: January 2017

Background and Goals:
Crohn’s disease (CD) is an inflammatory bowel disease, which can lead to abdominal pain, weight loss, fatigue, severe diarrhea, and malnutrition. Despite enormous efforts and progress in diagnosis and therapy, there are still many aspects of uncertainty leading to an increasing scientific interest in this topic. As it is challenging to survey all articles regarding CD and to measure their scientific importance, this study uses reliable scientometric tools to evaluate the global research output on CD related to quantitative and qualitative aspects and in chronological and geographical context.

Study:
We conducted a scientometric analysis to assess all global research activity on CD from 1900 until 2013. We analyzed the research output of countries, individual institutions, journals, authors and their collaborative networks and depicted our findings by density-equalizing map projections.

Results:
The worldwide research architecture indicated that the United States, the United Kingdom, Germany, and France play leading role regarding scientific activity, h-indices, multilateral and bilateral cooperations. There is a dramatic increase of collaborative publications since the 1990s, which underlines recent studies pronouncing that the scientific progress will be mainly depending on international cooperations.

Conclusions:
We conclude that the field of CD is constantly progressing, in which the influence of international cooperations on the scientific productivity is of major and growing importance. North American and Western European nations constitute the scientific leaders in the field of CD whereas developing or underdeveloped countries did not exhibit considerable research productivity.
Familial dysbetalipoproteinemia: an underdiagnosed lipid disorder
Authors: Koopal Charlotte , Marais A. David , Visseren Frank L.J. 
Published: January 2017

Purpose of review
To review pathophysiological, epidemiological and clinical aspects of familial dysbetalipoproteinemia; a model disease for remnant metabolism and remnant-associated cardiovascular risk.

Recent findings
Familial dysbetalipoproteinemia is characterized by remnant accumulation caused by impaired remnant clearance, and premature cardiovascular disease. Most familial dysbetalipoproteinemia patients are homozygous for apolipoprotein ε2, which is associated with decreased binding of apolipoprotein E to the LDL receptor. Although familial dysbetalipoproteinemia is an autosomal recessive disease in most cases, 10% is caused by autosomal dominant mutations. Of people with an ε2ε2 genotype 15% develops familial dysbetalipoproteinemia, which is associated with secondary risk factors, such as obesity and insulin resistance, that inhibit remnant clearance by degradation of the heparan sulfate proteoglycan receptor. The prevalence of familial dysbetalipoproteinemia ranges from 0.12 to 0.40% depending on the definition used. Clinical characteristics of familial dysbetalipoproteinemia are xanthomas and mixed hyperlipidemia (high total cholesterol and triglycerides); the primary lipid treatment goal in familial dysbetalipoproteinemia is non-HDL-cholesterol; and treatment consists of dietary therapy and treatment with statin and fibrate combination.

Summary
Familial dysbetalipoproteinemia is a relatively common, though often not diagnosed, lipid disorder characterized by mixed hyperlipidemia, remnant accumulation and premature cardiovascular disease, which should be treated with dietary therapy and statin and fibrate combination.
Mediators of diabetic neuropathy: is hyperglycemia the only culprit?
Authors: Grisold Anna , Callaghan Brian C. , Feldman Eva L. 
Published: January 2017

Purpose of review
Diabetic peripheral neuropathy (DPN) is a disabling, highly prevalent complication of both type 1 and type 2 diabetes mellitus (T1DM and T2DM). Large clinical studies support the concept that, in addition to hyperglycemia, components of the metabolic syndrome (MetS) may underlie the pathogenesis of DPN, especially in T2DM. This review will present the evidence supporting the MetS and its individual components as potential causal factors for the development of neuropathy.

Recent findings
In addition to poor glycemic control and duration of diabetes, components of MetS such as dyslipidemia, obesity, and hypertension may have an important impact on the prevalence of DPN. Obesity and prediabetes have the most data to support their role in neuropathy, whereas hypertension and dyslipidemia have more mixed results. Nonmetabolic factors, such as genetic susceptibility, age, height, sex, smoking, and alcohol, have also been highlighted as potential risk factors in peripheral neuropathy, although the exact contribution of these factors to DPN remains unknown.

Summary
DPN is a chronic and disabling disease, and the accurate identification and modification of DPN risk factors is important for clinical management. Recent data support a role for components of the MetS and other risk factors in the development of DPN, offering novel targets beyond hyperglycemia for therapeutic development.
Primary Septal Cartilage Graft for the Unilateral Cleft Rhinoplasty
Authors: Lu Ting-Chen , Yao Chuan-Fong , Lin Susie , Chang Chun-Shin , Chen Philip Kuo-Ting 
Published: January 2017

Background:
Since 2006, the authors have explored the option of using septal cartilage as an alar rim graft on the cleft side during primary rhinoplasty to improve nasal symmetry. The aim of this study was to compare the nasal shape with or without rim graft.

Methods:
A total of 98 patients with unilateral complete cleft lip and palate were included; 39 patients had septal cartilage as the rim graft, and 59 patients did not. Measurements of the nostril height, nostril width, one-fourth medial part of nostril height, nostril area, nasal dome height, and nostril axis were obtained on the cleft and noncleft sides. Ratios of these measurements were calculated. These ratios were then compared between the graft and nongraft groups. The levels of asymmetry were categorized into four levels—less than 5 percent, 5 to 10 percent, 10 to 15 percent, and greater than 15 percent—based on the percentages deviated from perfect symmetry (100 percent). Panel assessment was also performed. Nasolabial angle and tip projection ratio were measured for the comparison of nasal growth.

Results:
The nostril height, height-to-width ratio, and nasal dome height were higher in the graft group (p = 0.003, p < 0.001, and p < 0.001, respectively). The graft group showed more consistency regarding the nostril shape and axis, and the differences were statistically significant (p < 0.05). The nasolabial angle and tip projection ratio showed no significant difference between the two groups.

Conclusion:
This preliminary study suggests that the use of a primary septal cartilage graft may offer better support at the alar rim and improve the long-term outcomes.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.
Overrun causations under advance payment regimes
Authors: Aje Olaniyi Isaac , Olatunji Oluwole Alfred , Olalusi Olanrewaju Augustine 
Published: January 2017

Purpose
Evidence suggests project owners could use advance payments to prevent cost escalations. The purpose of this paper is to elicit the relationships between causations of overruns when advance payments are issued to contractors.

Design/methodology/approach
In total, 97 responses from a questionnaire survey were analysed. Additional data on 51 projects, completed between 2000 and 2014 under different advance payments regimes, were also obtained and analysed.

Findings
Project owners issue advance payments to contractors so as to avoid delays. However, statistical correlation between advance payments and overrun causations are not significant. Although cost overruns were higher in large projects than in small projects, schedule overruns were more in small projects than in large projects. Schedule overruns were caused most significantly by contractors’ site management approaches. Design and documentation issues were identified as the most prevalent cause of cost overruns. Regression models are proposed to elicit overruns when advance payments are issued.

Practical implications
Extant debates on project overruns in construction and project management literature are robust. Nonetheless, the study elicits considerable knowledge gaps regarding the roles of advance payments in fostering project performance.

Originality/value
This pioneering work indexes the relationship between advance payment and project overruns in Nigeria. It is also the first attempt to document the probability distribution of overruns in Nigeria, particularly under specific advance payment regimes.
Physical asset management practices in the Saudi public sector
Authors: Naief Alhazmi 
Published: January 2017

Purpose
The purpose of this paper is to understand the characteristics of the current asset management (AM) practices across the Saudi public sector (SPS).

Design/methodology/approach
The study uses a mixture of inductive and deductive logic, including, at the outset, developing a framework tool to assess the SPS using thematic analysis. The framework is based on seven well-known international AM standards and guidelines. Later, a structured interview with 196 items is used to capture characteristics of SPS AM practices. Univariate and interpretive analyses were performed.

Findings
AM practices across the SPS are characterised by the following: in the majority of ministries, practices are below expectations; performance indicators are unrealistic and incomprehensive; public servants lack awareness of AM practices; the majority of the public sector overlooks the existence of professional standards; policies are not consistent across the sector; and finally, there is an over-reliance on public servants’ experience.

Research limitations/implications
Policy implications – current AM practices across the SPS need to be established, in particular by introducing policies and professional standards.

Originality/value
Physical assets are vital resources for organisations and, in turn, countries. There are no extant studies about AM practices across the SPS, and thus the evident need for such studies to develop current SPS knowledge, particularly given the notable increase in the country’s physical assets since its emergence and the formal AM practice development worldwide.