bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pars Plana Vitrectomy With in Vivo Cyst Lysis for Intraocular Cysticercosis
Authors: Azad Shorya , Takkar Brijesh , Roy Sangeeta , Gangwe Anil B. , Kumar Mahesh , Kumar Atul 
Published: July 2016

BACKGROUND AND OBJECTIVE:
To evaluate efficacy and safety of pars plana vitrectomy (PPV) and in vivo cyst lysis for intraocular cysticercosis.

PATIENTS AND METHODS:
Retrospective analysis of the records of 15 patients undergoing PPV for intraocular cysticercosis at a tertiary eye care center was done. All patients had undergone in vivo cyst lysis. Of these 15 patients, one had intravitreal cysticercosis (IVC) with vitritis, two cases had IVC with vitritis with tractional retinal detachment (TRD), four cases had subretinal cysticercosis (SRC), four cases had SRC with extensive fibrosis without TRD, and five cases had SRC with fibrosis with TRD. Postoperative visual acuity at 3 months of follow-up was analyzed as the primary outcome measure.

RESULTS:

Mean age of patients was 26 years ± 12.27 years. Four out of 15 patients were female. Mean preoperative best-corrected visual acuity (BCVA) was 1.55 logMAR units ± 0.62 logMAR units, whereas mean postoperative BCVA at last follow-up (3 months) was 1.26 logMAR units ± 0.65 log-MAR units. Mean visual gain (0.29 logMAR units) post-surgery was statistically significant (
P
= .018). The final visual acuity correlated with preoperative BCVA with Pearson's coefficient being 0.78 (95% CI, 0.44–0.92;
P
= .001). Anatomical success was achieved in 13 of 15 (87%) cases. In one case the cyst was dead and calcified and could not be removed. TRD was associated with poor visual gain.

CONCLUSION:
Intravitreal cyst lysis is a safe and successful approach for managing intraocular cysticercosis. Visual results depend on preoperative condition. TRD implicates poor visual prognoses.

[
Ophthalmic Surg Lasers Imaging Retina
. 2016;47:665–669.]
Clonal Characteristics of Circulating B Lymphocyte Repertoire in Primary Biliary Cholangitis
Authors: Tan Yan-guo , Wang Yu-qi , Zhang Ming , Han Ying-xin , Huang Chun-yang , Zhang Hai-ping , Li Zhuo-min , Wu Xiao-lei , Wang Xiao-feng , Dong Yan , Zhu Hong-mei , Zhu Shi-da , Li Hong-mei , Li Ning , Yan Hui-ping , Gao Zu-hua 
Published: July 2016

Abstract
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by elevated serum anti-mitochondrial Ab and lymphocyte-mediated bile duct damage. This study was designed to reveal the clonal characteristics of B lymphocyte repertoire in patients with PBC to facilitate better understanding of its pathogenesis and better management of these patients. Using high-throughput sequencing of Ig genes, we analyzed the repertoire of circulating B lymphocytes in 43 patients with PBC, and 34 age- and gender-matched healthy controls. Compared with healthy controls, PBC patients showed 1) a gain of 14 new clones and a loss of 8 clones; 2) a significant clonal expansion and increased relative IgM abundance, which corresponded with the elevated serum IgM level; 3) a significant reduction of clonal diversity and somatic hypermutations in class-switched sequences, which suggested a general immunocompromised status; 4) the reduction of clonal diversity and enhancement of clonal expansion were more obvious at the cirrhotic stage; and 5) treatment with ursodeoxycholic acid could increase the clonal diversity and reduce clonal expansion of the IgM repertoire, with no obvious effect on the somatic hypermutation level. Our data suggest that PBC is a complex autoimmune disease process with evidence of B lymphocyte clonal gains and losses, Ag-dependent ogligoclonal expansion, and a generally compromised immune reserve. This new insight into the pathogenesis of PBC opens up the prospect of studying disease-relevant B cells to better diagnose and treat this devastating disease.
The Minor MHC Class I Gene UDA of Ducks Is Regulated by Let-7 MicroRNA
Authors: Chan Wing Fuk , Parks-Dely Julie A. , Magor Brad G. , Magor Katharine E. 
Published: July 2016

Abstract
In many nonmammalian vertebrates, the genomic organization of the MHC class I region leads to biased expression of a single classical MHC class I gene coevolving with TAP transporters, whereas class I genes are poorly expressed. This contrasts to the three codominantly expressed classical MHC class I genes in humans and mice. In a sequenced haplotype from White Pekin duck, Anas platyrhynchos, there is one predominantly expressed MHC class I, UAA, although they have five MHC class I genes in the complex, arranged TAP1-TAP2-UAA-UBA-UCA-UDA-UEA. The UAA gene, situated proximal to the TAP2 gene, is expressed at levels 10-fold greater than that of another expressed gene, UDA. Three duck MHC class I genes (UBA, UCA, and UEA) are predicted to be partially or completely inactivated by promoter defects, introduction of in-frame stop codon, or the lack of a polyadenylation signal. In this study, we confirm that UBA, UCA, and UEA are indeed inactivated through genetic defects at the promoter, whereas UAA and UDA have functionally equivalent promoters. To examine promoter accessibility, we performed bisulfite sequencing and show that none of the MHC class I promoters are inactivated by methylation. We determine that UDA is differentially regulated through its 3′ untranslated region. Namely, expression of UDA is downregulated by let-7 microRNA, whereas the predominantly expressed MHC class I UAA is not. Regulation of UDA by let-7 microRNA suggests that the lower expression level is maintained for its function in immunity.
Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells
Authors: Naradikian Martin S. , Myles Arpita , Beiting Daniel P. , Roberts Kenneth J. , Dawson Lucas , Herati Ramin Sedaghat , Bengsch Bertram , Linderman Susanne L. , Stelekati Erietta , Spolski Rosanne , Wherry E. John , Hunter Christopher , Hensley Scott E. , Leonard Warren J. , Cancro Michael P. 
Published: July 2016

Abstract
T-bet and CD11c expression in B cells is linked with IgG2c isotype switching, virus-specific immune responses, and humoral autoimmunity. However, the activation requisites and regulatory cues governing T-bet and CD11c expression in B cells remain poorly defined. In this article, we reveal a relationship among TLR engagement, IL-4, IL-21, and IFN-γ that regulates T-bet expression in B cells. We find that IL-21 or IFN-γ directly promote T-bet expression in the context of TLR engagement. Further, IL-4 antagonizes T-bet induction. Finally, IL-21, but not IFN-γ, promotes CD11c expression independent of T-bet. Using influenza virus and Heligmosomoides polygyrus infections, we show that these interactions function in vivo to determine whether T-bet+ and CD11c+ B cells are formed. These findings suggest that T-bet+ B cells seen in health and disease share the common initiating features of TLR-driven activation within this circumscribed cytokine milieu.
Subnotificação de casos de tuberculose a partir da vigilância do óbito
Authors: Romero Renata Olívia Gadelha , Ribeiro Cláudia Maria Cavalcanti , Sá Lenilde Duarte de , Villa Tereza Cristina Scatena , Nogueira Jordana De Almeida 
Published: July 2016

Objetivou-se analisar as subnotificações de casos de tuberculose a partir de captação de óbitos registrados no Sistema de Informação de Mortalidade (SIM) entre 2007 a 2011. Estudo retrospectivo, realizado em municipio nordestino, que utilizou a técnica de associação probabilística entre os registros do SIM e Sistema de Informação de Agravos de Notificação (Sinan), por meio do software Reclink III. Calculou-se odds ratio (OR) dos indivíduos que morreram com tuberculose não notificados no Sinan, segundo características sociodemográficas. Do total de 147 óbitos registrados no SIM, 72,8% não haviam sido notificados no Sinan. Mulheres tiveram mais chance que os homens de não serem notificadas (OR=2,60), pessoas com idade inferior a 60 anos (OR=1,86) e com menos de oito anos de estudo (OC=4,42). Estratégias devem ser ressignificadas de modo a aumentar a captação de sintomáticos respiratórios, diagnosticar oportunamente os casos e evitar falhas no preenchimento dos registros.
O conhecimento científico e a multimodalidade informacional
Authors: Assumpção Luiz Carlos Flôres , Lopez André Porto Ancona 
Published: July 2016

<p><strong>Introdução:</strong> No contexto científico, a informação só poderá ser considerada objetivo científico se forem dentro de normas e regras preestabelecidas, ou seja, com as informações registradas - teorias e resultados de pesquisas - o que pode ser colocado à prova, sendo refutada ou não.</p><p><strong>Objetivo:</strong> Analisar a informação multimodal no contexto do conhecimento científico com a teoria dos três mundos de Popper.</p><p><strong>Metodologia:</strong> E o ponto de partida é uma pesquisa bibliográfica. No primeiro momento, a definição do que é informação e informação como coisa. No segundo momento, vamos nos ater ao contexto da informação multimodal, passando o terceiro momento nas teorias de três mundos de Popper e em particular o terceiro mundo ou mundo 3.</p><p><strong>Resultado:</strong> No terceiro momento as considerações em defesa da informação gravada para fazer parte da estrutura do contexto científico onde a informação é considerada como algo multimodal física e tangível para ser do mundo 1, e do mundo 3 de Popper.</p><strong>Conclusão:</strong>Nesta análise pudemos inferir que a informação multimodal faz parte do contexto científico e é estruturada como uma coisa fazendo parte do terceiro mundo de Popper<p> </p>
A Memória organizacional nos processos de gestão do conhecimento: um estudo na Universidade Federal do Paraná
Authors: Pereira Maria Olívia Ferreira , Silva Helena de Fátima Nunes , Pinto José Simão de Paula 
Published: July 2016

<p><strong>Introdução</strong>: A Memória Organizacional permite a identificação, o registro, o uso e reuso de informações e conhecimentos construídos a partir da prática. As Universidades precisam aperfeiçoar as suas práticas relacionadas à utilização e reutilização de informações decorrentes de experiências vivenciadas e aprendidas por elas.</p><p><strong>Objetivo</strong>: Busca identificar a memória organizacional como um elemento que envolve a representação do conhecimento e da informação como uma prática da Gestão do Conhecimento na Universidade Federal do Paraná.</p><p><strong>Metodologia</strong>: Estudo de natureza exploratória, apoiado em uma revisão da literatura. A coleta de dados foi realizada por meio de um questionário <em>online</em> com os funcionários que trabalham na Pró-Reitoria de Pesquisa e Pós-Graduação – PRPPG da UFPR.</p><p><strong>Resultados</strong>: Os resultados apresentam dados sobre a escolaridade do pessoal estudado. É observado que os funcionários percebem a importância da Memória Organizacional, mas ainda não tem consciência da sua relevância como elemento essencial de gestão.</p><p><strong>Conclusões</strong>: Conclui que a memória organizacional deve ser utilizada como um instrumento que propicia o compartilhamento e reuso do conhecimento corporativo e individual. </p>
Maturidade em gestão do conhecimento: análise das percepções dos gestores de uma grande empresa de construção civil
Authors: Natale Carlos Henrique Cotta , Neves Jorge Tadeu Ramos , Carvalho Rodrigo Baroni 
Published: July 2016

<p><strong>Introdução:</strong> A partir da aplicação de um modelo de maturidade em Gestão do Conhecimento (GC), uma empresa pode ser capaz de identificar práticas de GC que podem ser melhoradas e, ou, implantadas.</p><p><strong>Objetivo:</strong> O objetivo é identificar a percepção dos gestores em relação à maturidade das práticas de gestão do conhecimento em uma grande empresa de construção civil.</p><p><strong>Metodologia:</strong> Trata-se de uma pesquisa descritiva qualitativa conduzida em duas etapas com o grupo dos 15 principais gestores (alta administração) por meio de uma entrevista e questionário semiestruturado (100 questões e 6 níveis) lastreado no modelo de maturidade <em>Strategic Knowledge Management Maturity Model</em> (KRUGER; SNYMAN, 2007) </p><p><strong>Resultados:</strong> Constatou-se que a empresa está no estágio inicial de GC. O modelo S-KMMM permitiu identificar iniciativas departamentais isoladas e processos de GC que podem ser implantados e, ou, aprimorados.</p><strong>Conclusões:</strong> Observou-se que a aplicação do modelo de maturidade em gestão do conhecimento foi útil para que os gestores da empresa reconhecessem que as práticas de GC correntes são realizadas de maneira isolada, intuitiva e informal. A aplicação do modelo S-KMMM se mostrou válida para avaliação sistemática e alinhamento estratégico das iniciativas organizacionais de GC.
Práticas leitoras em Minas Gerais, século XIX: bibliotecas públicas e a leitura de jornais
Authors: Oliveira Flávia Silvestre , Carvalho Maria Da Conceição 
Published: July 2016

<p> </p><p> </p><p><strong>Introdução</strong>: O fim da proibição das atividades de impressão no Brasil, em 1808, provocou o aparecimento de grande número de jornais, deflagrando debates políticos e a propagação da prática de leitura informativa e literária.</p><p><strong>Objetivo: </strong>Investigar a ocorrência de práticas de leitura em Minas Gerais, no século XIX, especialmente a leitura de jornais em bibliotecas públicas das cidades de Ouro Prêto e São João del Rey.</p><p><strong>Metodologia</strong>: Revisão de literatura sobre História da Leitura, dialogando, sobretudo, com Darnton, Chartier, Abreu, Lajolo e Zilberman. Enquanto estudo com características de micro-história, definiu-se para a coleta de dados jornais publicados naqueles locais, no período, assim como documentos oficiais, e impressões de viajantes estrangeiros. Para a análise dos dados utilizou-se a análise documental.</p><p><strong>Resultados</strong>: As bibliotecas públicas foram responsáveis por facilitar o acesso dos habitantes da província à prática da leitura, em especial a leitura de jornais. Através das colunas do leitor criou-se um canal de participação política e de sociabilidade entre cidadãos de diferentes cidades do país.</p><p><strong>Conclusões</strong>: A sociedade mineira do século XIX, como já vinha acontecendo desde os movimentos da Inconfidência, fez da leitura de jornais um ato cotidiano vivido por indivíduos de diferentes classes sociais. Nas bibliotecas e sociedades literárias, como nas praças públicas, jornais e folhetos eram lidos em voz alta para proveito das pessoas mais pobres e iletradas que foram, de alguma forma, socialmente inseridas naquele momento de mudanças sociais e políticas.</p>
Sacrifício e quase-acontecimento: apontamentos sobre a visibilidade da luta pela terra dos povos indígenas Guarani e Kaiowa (Sacrifice and quasi event: notes on the visibility of the indigenous people Guarani and Kaiowa struggle over land)
Authors: Oliveira Luciana De , Benites Tonico , Neto Rui De Oliveira 
Published: July 2016

<p>Este artigo tem como objetivo discutir os entrecruzamentos entre o conceito de quase-acontecimento, a lógica do sacrifício e a constituição de disputas políticas no seio de uma cultura participativa. Toma como ponto de partida empírico o caso da visibilidade da luta pela terra conquistada pelos povos Guarani e Kaiowa em 2012, buscando identificar os mecanismos acionadores do debate público para uma análise sobre sua configuração e saldos políticos.</p><p> </p><p><strong>Abstract</strong></p><p>This article aims to discuss the intersections between the concept of quasi event, the sacrifice's logic and the constitution of political disputes within participatory culture. Starting from the case of the visibility of Guarani and Kaiowa's land struggle conquered in 2012, it seeks to identify the public debate's catalytic mechanisms in order to analyses its configuration and political results.</p><p><strong>Keywords</strong>:<strong> </strong>Quasi event. Sacrifice. Public debate. Participatory culture. Guarani e Kaiowa.</p>
Modelos de desenvolvimento, economia política e a questão do negro no Brasil. Entre choros e risos (Models of development, Political Economy and the Negro Question in Brazil. Between cries and laughter)
Authors: Siqueira José Jorge 
Published: July 2016

<p>Este artigo faz uma reflexão sobre as relações possíveis entre os modelos de desenvolvimento, a economia política como pensada no Brasil e a questão do negro neste país. Ocupa lugar central nas análises o conceito de “subdesenvolvimento” face à exclusão social das grandes massas populacionais da nação, atravessando tal exclusão as questões relacionadas à discriminação e ao preconceito racial.</p><p> </p><p><strong>Abstract</strong></p><p>It is a reflection on the possible links between the models of development, political economy as thought in Brazil and the Negro question in this country. Occupies a central place in the analysis the concepto of “underdevelopment” face social exclusion of large population groups, through such exclusion issues related to discrimination and racial prejudice.</p><p><strong>Keywords</strong>: Models of development. Political economy in Brazil. Negro question.</p><p> </p>
Incorporation of particles into the bulk of expanded polystyrene foam using physical vapour deposition technologies
Authors: Varnagiris Šarūnas , Donėlienė Jolanta , Tučkutė Simona , Vonžodas Tomas , Lelis Martynas , Milčius Darius 
Published: July 2016

Expanded polystyrene foam (EPS) is used for various applications because of its significant properties (low weight, low cost, good thermal insulation, etc.). However, some of EPS characteristics should be improved. Because of this, additional materials are incorporated into polystyrene. This article presents the results of particles incorporation into EPS bulk using physical vapour deposition (PVD). TiO2 was used as an additional material, which was incorporated into EPS foam. Non-expanded polystyrene beads were used as a substrate. These beads were treated with argon plasma in order to achieve better surface adhesion. Plasma was generated at 1 × 10–1 mbar pressure using a pulsed DC power source (frequency 20 kHz, voltage 400 V). Particles were deposited on the surface of non-expanded polystyrene beads. Titanium cathode was used as a primary material. The formation of particles was done using magnetron sputtering in reactive atmosphere. The mixture of argon and oxygen gas was used in order to form TiO2 particles (argon 82%, oxygen 18%). Vacuum pressure was 6 × 10–3 mbar during the particles formation process (power during deposition 240 W). Results showed that TiO2 particles were formed on the surface of non-expanded polystyrene beads. These particles remained stable after expansion of beads and compounded in onepiece foam of EPS. Particles were distributed uniformly in all bulk of EPS and remained in place even after flame torch induced heat resistance experiments. The modified EPS also showed photocatalytic activity during the bleaching of methylene blue (MB) aqueous solution under UV-B irradiation.
Selection of substrate material for hybrid microwave integrated circuits (HMICs)
Authors: Gupta Navneet , Mishra Abhinav 
Published: July 2016

This paper presents systematic approach of material selection for substrate material in hybrid microwave integrated circuits (HMICs). The performance of HMICs starts deteriorating at microwave frequencies because the circuit dimensions become comparable to the wavelength. So, it is important to design HMICs in such a way that its performance remains unaffected even at high frequencies. One way to fulfil this requirement is to fabricate a proper device. For this, substrate material in HMICs plays an important role. But there are different types of materials available which can be used as substrate material of HMICs. The commonly reported materials are: Silicon (Si), Gallium Arsenide (GaAs), Indium Phosphide (InP), Alumina (Al2O3), Beryllia, Fused Silica, Sapphire, Woven PTFF/ Glass, PTFE/Glass, Polyolefin, and Ferrite/Granite. As each material is having its own advantages and limitations; therefore, it is important to choose the best possible material out of all possible materials. For this purpose two decision making techniques are used. Firstly, Ashby’s approach as the Multi-Objective Decision Making (MODM) technique is used, and then the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) as the Multiple Attribute Decision Making (MADM) technique is used. Ashby’s approach provides effective material selection technique to select the best material based on their material and performance indices for better device performance. While TOPSIS approach is a decision making approach which is basically used to determine the best alternative which should have the shortest Euclidean distance (S*) from the ideal solution (A*) and the largest Euclidean distance (S-) from the negative ideal solution (A-). For MICs, the material indices considered and evaluated are surface roughness, relative dielectric constant, loss tangent, thermal conductivity, and dielectric strength. It is observed that Sapphire followed by high-purity Alumina (99.5 percent pure or better) are good candidates for substrate material in hybrid MICs. The surface roughness of Sapphire is better than that of Alumina, though the dielectric strength of both these materials is the same. A comparison between two different methods for material selection shows consistency between the two methods of material selection. Both methodologies show that Sapphire is the most suitable substrate material for hybrid MICs.
Globuligerina oxfordiana (Grigelis, 1958) – revision of the first planktonic foraminifera discovered in the Upper Jurassic of Lithuania
Authors: Grigelis Algimantas 
Published: July 2016

The article presents the self-revision and re-description of the first planktonic foraminifera Globuligerina oxfordiana (Grigelis, 1958) discovered in the Upper Jurassic of Lithuania. The original article published in 1958 in a Russian periodical (Moscow) is translated, supplied by additional comments, and illustrated by SEM laser electronic micrographs.
A Retrospective Case Series of a Dehydrated Amniotic Membrane Allograft for Treatment of Unresolved Diabetic Foot Ulcers
Authors: Rosenblum Barry I. 
Published: July 2016

Background:Foot ulcers are among the most serious complications of diabetes and can lead to amputation. Diabetic foot ulcers (DFUs) often fail to heal with standard wound care, thereby making new treatments necessary. This case series describes the addition of a dehydrated amniotic membrane allograft (DAMA) to standard care in unresolved DFUs.Methods:This is a single-center retrospective chart review of eight patients who had one to three applications of DAMA to nine DFUs that had failed to resolve despite offloading, other standard care, and adjuvant therapies. Following initial DAMA placement, wound size (length, width, depth) was measured every 1 to 2 weeks until closure. The principal outcome assessed was mean time to wound closure; other outcomes included mean percent reduction from baseline in wound area and volume at weeks 2 to 8.Results:All wounds were closed a mean of 9.2 weeks after the first DAMA application (range, 3.0–13.5 weeks). Compared with baseline, wound area and volume, respectively, were reduced by a mean of 48% and 60% at week 2 and by 89% and 91% at week 8. Time to closure was shorter among four patients who had three DAMA applications (mean, 8.3 weeks; range, 4.0–11.0 weeks) than among three patients who had only one application (mean, 12.1 weeks; range, 9.5–13.5 weeks).Conclusions:Chronic, unresolved DFUs treated with DAMA rapidly improved and reached closure in an average of 9.2 weeks. These cases suggest that DAMA can facilitate closure of DFUs that have failed to respond to standard treatments.