bluuebunny/crossref_metadata_2025_split huggingface dataset:
Context inference and prediction modeling in ubiquitous health GIS
Authors: Kaffash‐Charandabi Neda , Alesheikh Ali‐Asghar 
Published: February 2017

AbstractThe ever‐increasing population in cities intensifies environmental pollution that increases the number of asthmatic patients. Other factors that may influence the prevalence of asthma are atmospheric parameters, physiographic elements and personal characteristics. These parameters can be incorporated into a model to monitor and predict the health conditions of asthmatic patients in various contexts. Such a model is the base for any asthma early warning system. This article introduces a novel ubiquitous health system to monitor asthmatic patients. Ubiquitous systems can be effective in monitoring asthmatic patients through the use of intelligent frameworks. They can provide powerful reasoning and prediction engines for analyzing various situations. Our proposed model encapsulates several tools for preprocessing, reasoning and prediction of asthma conditions. In the preprocessing phase, outliers in the atmospheric datasets were detected and missing sensor data were estimated using a Kalman filter, while in the reasoning phase, the required information was inferred from the raw data using some rule‐based inference techniques. The asthmatic conditions of patients were predicted accurately by a Graph‐Based Support Vector Machine in a Context Space (GBSVMCS) which functions anywhere, anytime and with any status. GBSVMCS is an improved version of the common Support Vector Machine algorithm with the addition of unlabeled data and graph‐based rules in a context space. Based on the stored value for a patient's condition and his/her location/time, asthmatic patients can be monitored and appropriate alerts will be given. Our proposed model was assessed in Region 3 of Tehran, Iran for monitoring three different types of asthma: allergic, occupational and seasonal asthma. The input data to our system included air pollution data, the patients’ personal information, patients’ locations, weather data and geographical information for 270 different situations. Our results showed that 90% of the system's predictions were correct. The proposed model also improved the estimation accuracy by 15% in comparison to conventional methods.
Mario Becomes Cognitive
Authors: Schrodt Fabian , Kneissler Jan , Ehrenfeld Stephan , Butz Martin V. 
Published: February 2017

AbstractIn line with Allen Newell's challenge to develop complete cognitive architectures, and motivated by a recent proposal for a unifying subsymbolic computational theory of cognition, we introduce the cognitive control architecture SEMLINCS. SEMLINCS models the development of an embodied cognitive agent that learns discrete production rule‐like structures from its own, autonomously gathered, continuous sensorimotor experiences. Moreover, the agent uses the developing knowledge to plan and control environmental interactions in a versatile, goal‐directed, and self‐motivated manner. Thus, in contrast to several well‐known symbolic cognitive architectures, SEMLINCS is not provided with production rules and the involved symbols, but it learns them. In this paper, the actual implementation of SEMLINCS causes learning and self‐motivated, autonomous behavioral control of the game figure Mario in a clone of the computer game Super Mario Bros. Our evaluations highlight the successful development of behavioral versatility as well as the learning of suitable production rules and the involved symbols from sensorimotor experiences. Moreover, knowledge‐ and motivation‐dependent individualizations of the agents’ behavioral tendencies are shown. Finally, interaction sequences can be planned on the sensorimotor‐grounded production rule level. Current limitations directly point toward the need for several further enhancements, which may be integrated into SEMLINCS in the near future. Overall, SEMLINCS may be viewed as an architecture that allows the functional and computational modeling of embodied cognitive development, whereby the current main focus lies on the development of production rules from sensorimotor experiences.
IMAGING DIAGNOSIS —ANTEMORTEM DETECTION OF OLIGODENDROGLIOMA “CEREBROSPINAL FLUID DROP METASTASES” IN A DOG BY SERIAL MAGNETIC RESONANCE IMAGING
Authors: Vigeral Mariana , Bentley R. Timothy , Rancilio Nicholas J. , Miller Margaret A. , Heng Hock Gan 
Published: February 2017

AbstractAn English Bulldog underwent radiation therapy of an intracranial, left lateral ventricle mass. Following resolution of the primary mass, an intraventricular fourth ventricle lesion developed. Subsequently, multiple lesions developed from the cervical central canal and leptomeninges. Serial magnetic resonance imaging documented the propagation of lesions along the cerebrospinal fluid (CSF) pathways, known as “CSF drop metastasis.” Histopathology confirmed multifocal intraventricular and leptomeningeal oligodendroglioma. Oligodendroglioma should be included in the differential diagnosis for an intraventricular tumor exhibiting apparent CSF drop metastasis.
Comparison of leak pressures for single‐layer simple continuous suture pattern for cystotomy closure using barbed and monofilament suture material in an ex vivo canine model*
Authors: Kieves Nina R. , Krebs Alexander I. 
Published: February 2017

AbstractObjectiveTo compare leak pressures following simple continuous closure of cystotomy with barbed suture to an analogous monofilament suture, in an ex vivo canine model.Study designEx vivo, simple randomized study.Animals or sample populationUrinary bladders harvested from canine cadavers (n = 21).MethodsUrinary bladders were harvested from cadavers immediately following euthanasia. A 3‐cm cystotomy was made on ventral midline of the urinary bladder. Urinary bladders were randomly assigned a suture for closure. A digital pressure transducer was inserted through 1 ureter, and the other ligated, while colored isotonic saline was infused into the urinary bladder via a Foley catheter inserted in the urethra. The initial leak pressure was defined as the pressure at which the colored saline solution first leaked from the cystotomy, and the maximum leak pressure was recorded when the pressure reached a plateau or catastrophic failure occurred. A Welch's 2‐sample t test was used to compare leak pressure between the barbed and non‐barbed closures, with significance set at P < .05.ResultsThere was no significant difference in the initial or maximum leak pressure between the barbed and non‐barbed closures.ConclusionsThis study showed no difference in initial or maximum leak pressure between cystotomy closures with barbed or non‐barbed suture under ex vivo conditions. This indicates barbed suture may be appropriate for cystotomy closure but in vivo studies are needed to support this finding.
Generalized and degenerate Whittaker models
Authors: Gomez Raul , Gourevitch Dmitry , Sahi Siddhartha 
Published: February 2017

We study generalized and degenerate Whittaker models for reductive groups over local fields of characteristic zero (archimedean or non-archimedean). Our main result is the construction of epimorphisms from the generalized Whittaker model corresponding to a nilpotent orbit to any degenerate Whittaker model corresponding to the same orbit, and to certain degenerate Whittaker models corresponding to bigger orbits. We also give choice-free definitions of generalized and degenerate Whittaker models. Finally, we explain how our methods imply analogous results for Whittaker–Fourier coefficients of automorphic representations. For $\text{GL}_{n}(\mathbb{F})$ this implies that a smooth admissible representation $\unicode[STIX]{x1D70B}$ has a generalized Whittaker model ${\mathcal{W}}_{{\mathcal{O}}}(\unicode[STIX]{x1D70B})$ corresponding to a nilpotent coadjoint orbit ${\mathcal{O}}$ if and only if ${\mathcal{O}}$ lies in the (closure of) the wave-front set $\operatorname{WF}(\unicode[STIX]{x1D70B})$. Previously this was only known to hold for $\mathbb{F}$ non-archimedean and ${\mathcal{O}}$ maximal in $\operatorname{WF}(\unicode[STIX]{x1D70B})$, see Moeglin and Waldspurger [Modeles de Whittaker degeneres pour des groupes p-adiques, Math. Z. 196 (1987), 427–452]. We also express ${\mathcal{W}}_{{\mathcal{O}}}(\unicode[STIX]{x1D70B})$ as an iteration of a version of the Bernstein–Zelevinsky derivatives [Bernstein and Zelevinsky, Induced representations of reductive p-adic groups. I., Ann. Sci. Éc. Norm. Supér. (4) 10 (1977), 441–472; Aizenbud et al., Derivatives for representations of$\text{GL}(n,\mathbb{R})$and$\text{GL}(n,\mathbb{C})$, Israel J. Math. 206 (2015), 1–38]. This enables us to extend to $\text{GL}_{n}(\mathbb{R})$ and $\text{GL}_{n}(\mathbb{C})$ several further results by Moeglin and Waldspurger on the dimension of ${\mathcal{W}}_{{\mathcal{O}}}(\unicode[STIX]{x1D70B})$ and on the exactness of the generalized Whittaker functor.
Lysophosphatidic acid‐induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1
Authors: Kittaka Hiroki , Uchida Kunitoshi , Fukuta Naomi , Tominaga Makoto 
Published: February 2017

Key points
Lysophosphatidic acid (LPA) is an itch mediator, but not a pain mediator by a cheek injection model.
Dorsal root ganglion neurons directly respond to LPA depending on transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1).
LPA‐induced itch‐related behaviours are decreased in TRPA1‐knockout (KO), TRPV1KO or TRPA1TRPV1 double KO mice.
TRPA1 and TRPV1 channels are activated by intracellular LPA, but not by extracellular LPA following LPA5 receptor activation with an activity of Ca2+‐independent phospholipase A2 and phospholipase D.
Intracellular LPA interaction sites of TRPA1 are KK672–673 and KR977–978 (K: lysine, R: arginine).
AbstractIntractable and continuous itch sensations often accompany diseases such as atopic dermatitis, neurogenic lesions, uremia and cholestasis. Lysophosphatidic acid (LPA) is an itch mediator found in cholestatic itch patients and it induces acute itch and pain in experimental rodent models. However, the molecular mechanism by which LPA activates peripheral sensory neurons remains unknown. In this study, we used a cheek injection method in mice to reveal that LPA induced itch‐related behaviours but not pain‐related behaviours. The LPA‐induced itch behaviour and cellular effects were dependent on transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1), which are important for itch signal transduction. We also found that, among the six LPA receptors, the LPA5 receptor had the greatest involvement in itching. Furthermore, we demonstrated that phospholipase D (PLD) plays a critical role downstream of LPA5 and that LPA directly and intracellularly activates TRPA1 and TRPV1. These results suggest a unique mechanism by which cytoplasmic LPA produced de novo could activate TRPA1 and TRPV1. We conclude that LPA‐induced itch is mediated by LPA5, PLD, TRPA1 and TRPV1 signalling, and thus targeting TRPA1, TRPV1 or PLD could be effective for cholestatic itch interventions.
Patient compliance with new oral anticoagulants after major orthopaedic surgery: rivaroxaban and dabigatran compared with subcutaneous injection of fondaparinux
Authors: Di Benedetto Paolo , Vetrugno Luigi , De Franceschi Dania , Gisonni Renato , Causero Araldo , Rocca Giorgio 
Published: February 2017

Purpose: the main purpose of our study was to compare patient compliance with the orally administered new oral anticoagulants (NOCs) dabigatran and rivaroxaban compared with subcutaneously injected fondaparinux after major orthopaedic surgery, and to assess patient preference for the oral vs subcutaneous administration route.
Methods: prophylactic antithrombotic drug therapy with dabigatran (group D; GD, n=32 patients), rivaroxaban (group R; GR, n=38 patients) or fondaparinux (group F; GF, n=30 patients), to prevent deep vein thrombosis, was started immediately after surgery in 100 patients submitted to total hip arthroplasty.
Results: the patients had a mean age of 68.7±11 years and 62% were female. In GD, 87.5% of patients indicated that they preferred oral intake of medications to subcutaneous injection (12.5%). In GR, 84.2% declared a preference for oral administration over subcutaneous injection (15.8%). In GF, a surprisingly high proportion of patients (73.3%; p < 0.001) declared that they preferred subcutaneous administration of medications over the oral route (26.7%). Overall, the rate of compliance with antithrombotic drug therapy was very high, at 99%.
Conclusions: intake of the NOAs dabigatran and rivaroxaban following hospital discharge is entirely the responsibility of the patient; a high level of patient compliance with these drugs must therefore be demonstrated in order for them to become well accepted within the medical community. The results of this study showed a very high level of compliance both with orally and subcutaneously administered drugs.
Level of evidence: Level I, randomized clinical study.
Surgical repair of isolated triceps tendon rupture using a suture anchor technique: a case report
Authors: Mancini Federico , Bernardi Gabriele , De Luna Vincenzo , Tudisco Cosimo 
Published: February 2017

Rupture or avulsion of the distal triceps tendon is one of the least common tendon injuries. The most common clinical presentation of the injury is avulsion from the olecranon. The diagnosis of acute triceps tendon rupture may be missed and this can result in prolonged disability.We report the case of a 42-year-old man with isolated triceps rupture treated by an open surgical repair technique involving the use of bone suture anchors.
Bacillus subtilis
Swarmer Cells Lead the Swarm, Multiply, and Generate a Trail of Quiescent Descendants
Authors: Hamouche Lina , Laalami Soumaya , Daerr Adrian , Song Solène , Holland I. Barry , Séror Simone J. , Hamze Kassem , Putzer Harald 
Published: February 2017

ABSTRACT

Bacteria adopt social behavior to expand into new territory, led by specialized swarmers, before forming a biofilm. Such mass migration of
Bacillus subtilis
on a synthetic medium produces hyperbranching dendrites that transiently (equivalent to 4 to 5 generations of growth) maintain a cellular monolayer over long distances, greatly facilitating single-cell gene expression analysis. Paradoxically, while cells in the dendrites (nonswarmers) might be expected to grow exponentially, the rate of swarm expansion is constant, suggesting that some cells are not multiplying. Little attention has been paid to which cells in a swarm are actually multiplying and contributing to the overall biomass. Here, we show
in situ
that DNA replication, protein translation and peptidoglycan synthesis are primarily restricted to the swarmer cells at dendrite tips. Thus, these specialized cells not only lead the population forward but are apparently the source of all cells in the stems of early dendrites. We developed a simple mathematical model that supports this conclusion.

IMPORTANCE
Swarming motility enables rapid coordinated surface translocation of a microbial community, preceding the formation of a biofilm. This movement occurs in thin films and involves specialized swarmer cells localized to a narrow zone at the extreme swarm edge. In the
B. subtilis
system, using a synthetic medium, the swarm front remains as a cellular monolayer for up to 1.5 cm. Swarmers display high-velocity whirls and vortexing and are often assumed to drive community expansion at the expense of cell growth. Surprisingly, little attention has been paid to which cells in a swarm are actually growing and contributing to the overall biomass. Here, we show that swarmers not only lead the population forward but continue to multiply as a source of all cells in the community. We present a model that explains how exponential growth of only a few cells is compatible with the linear expansion rate of the swarm.
Endorsement of PRISMA statement and quality of systematic reviews and meta-analyses published in nursing journals: a cross-sectional study
Authors: Tam Wilson W S , Lo Kenneth K H , Khalechelvam Parames 
Published: February 2017

ObjectiveSystematic reviews (SRs) often poorly report key information, thereby diminishing their usefulness. Previous studies evaluated published SRs and determined that they failed to meet explicit criteria or characteristics. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was recommended as a reporting guideline for SR and meta-analysis (MA), but previous studies showed that adherence to the statement was not high for SRs published in different medical fields. Thus, the aims of this study are twofold: (1) to investigate the number of nursing journals that have required or recommended the use of the PRISMA statement for reporting SR, and (2) to examine the adherence of SRs and/or meta-analyses to the PRISMA statement published in nursing journals.DesignA cross-sectional study.MethodsNursing journals listed in the ISI journal citation report were divided into 2 groups based on the recommendation of PRISMA statement in their ‘Instruction for Authors’. SRs and meta-analyses published in 2014 were searched in 3 databases. 37 SRs and meta-analyses were randomly selected in each group. The adherence of each item to the PRISMA was examined and summarised using descriptive statistics. The quality of the SRs was assessed by Assessing the Methodological Quality of Systematic Reviews. The differences between the 2 groups were compared using the Mann-Whitney U test.ResultsOut of 107 nursing journals, 30 (28.0%) recommended or required authors to follow the PRISMA statement when they submit SRs or meta-analyses. The median rates of adherence to the PRISMA statement for reviews published in journals with and without PRISMA endorsement were 64.9% (IQR: 17.6–92.3%) and 73.0% (IQR: 59.5–94.6%), respectively. No significant difference was observed in any of the items between the 2 groups.ConclusionsThe median adherence of SRs and meta-analyses in nursing journals to PRISMA is low at 64.9% and 73.0%, respectively. Nonetheless, the adherence level of nursing journals to the PRISMA statement does not significantly vary whether they endorse or recommend such a guideline.
Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF
Authors: Rotondo John Charles , Bononi Ilaria , Puozzo Andrea , Govoni Marcello , Foschi Valentina , Lanza Giovanni , Gafà Roberta , Gaboriaud Pauline , Touzé Françoise Antoine , Selvatici Rita , Martini Fernanda , Tognon Mauro 
Published: February 2017

AbstractPurpose: The purpose of this investigation was to characterize Merkel cell carcinomas (MCC) arisen in patients affected by autoimmune diseases and treated with biologic drugs.Experimental Design: Serum samples from patients with MCC were analyzed for the presence and titer of antibodies against antigens of the oncogenic Merkel cell polyomavirus (MCPyV). IgG antibodies against the viral oncoproteins large T (LT) and small T (ST) antigens and the viral capsid protein-1 were analyzed by indirect ELISA. Viral antigens were recombinant LT/ST and virus-like particles (VLP), respectively. MCPyV DNA sequences were studied using PCR methods in MCC tissues and in peripheral blood mononuclear cells (PBMC). Immunohistochemical (IHC) analyses were carried out in MCC tissues to reveal MCPyV LT oncoprotein.Results: MCPyV DNA sequences identified in MCC tissues showed 100% homology with the European MKL-1 strain. PBMCs from patients tested MCPyV-negative. Viral DNA loads in the three MCC tissues were in the 0.1 to 30 copy/cell range. IgG antibodies against LT/ST were detected in patients 1 and 3, whereas patient 2 did not react to the MCPyV LT/ST antigen. Sera from the three patients with MCC contained IgG antibodies against MCPyV VP1. MCC tissues tested MCPyV LT-antigen–positive in IHC assays, with strong LT expression with diffuse nuclear localization. Normal tissues tested MCPyV LT–negative when employed as control.Conclusions: We investigated three new MCCs in patients affected by rheumatologic diseases treated with biologic drugs, including TNF. A possible cause–effect relationship between pharmacologic immunosuppressive treatment and MCC onset is suggested. Indeed, MCC is associated with MCPyV LT oncoprotein activity. Clin Cancer Res; 23(14); 3929–34. ©2017 AACR.
An Improved of Multiple Harmonic Sources Identification in Distribution System with Inverter Loads by Using Spectrogram
Authors: Jopri M.H. , Abdullah A.R. , Manap M. , Yusoff M.R. , Sutikno T. , Habban M.F. 
Published: February 2017

This paper introduces an improved of multiple harmonic sources identification that been produced by inverter loads in power system using time-frequency distribution (TFD) analysis which is spectrogram. The spectrogram is a very applicable method to represent signals in time-frequency representation (TFR) and the main advantages of spectrogram are the accuracy, speed of the algorithm and use low memory size such that it can be computed rapidly. The identification of multiple harmonic sources is based on the significant relationship of spectral impedances which are the fundamental impedance (Z1) and harmonic impedance (Zh) that extracted from TFR. To verify the accuracy of the proposed method, MATLAB simulations carried out several unique cases with different harmonic producing loads on IEEE 4-bus test feeder cases. It is proven that the proposed method is superior with 100% correct identification of multiple harmonic sources. It is envisioned that the method is very accurate, fast and cost efficient to localize harmonic sources in distribution system.