bluuebunny/crossref_metadata_2025_split huggingface dataset:
American cutaneous leishmaniasis in infancy and childhood
Authors: Paniz‐Mondolfi Alberto E. , Talhari Carolina , García Bustos María F , Rosales Tamara , Villamil‐Gomez Wilmer E. , Marquez Marilianna , Pérez Alvarez Alexandra M. , Tálamo Sánchez Alejandra I. , Rodriguez‐Morales Alfonso J. 
Published: July 2017

AbstractInfant and young child skin diseases are among the most common features of morbidity throughout the tropics. Because the skin is directly exposed to the environment, it is considerably affected by climatic and local conditions such as vectors and microorganisms, as in the case of leishmaniasis. In America the observed magnitude of cutaneous leishmaniasis in children has led to the study of increased risk of exposure of this group due to the possibility of peri‐ and intradomiciliary transmission. The present review pretends to make a concrete approach all through the broad and main figures of this parasitic disease, including the clinical, physiopathological, epidemiological, diagnostic, and therapeutic aspects, in order to be used as a practical source of reference for pediatricians leading with tropical cutaneous pathology in the region.
Venous thromboembolism prophylaxis in urology: A review
Authors: Saluja Manmeet , Gilling Peter 
Published: July 2017

AbstractVenous thromboembolism is potentially a lethal problem, and is associated with chronic morbidity. Venous thromboembolism is frequently diagnosed after urological surgery, yet the role of perioperative venous thromboembolism prophylaxis is not clearly defined. Any current recommendations are largely based on evidence derived from other surgical specialties. Even within different guidelines, there remains significant variation, suggesting a consensus is required. The present review aims to define the problem of venous thromboembolism within the urological population, and identifies patients at risk. It evaluates the role of various types of mechanical and pharmacological prophylaxis, along with its timing and duration of administration in common urological operations. The current guidelines are summarized and compared in order to give the reader a better perspective of this vital condition.
Serum γ‐glutamyltransferase level and metabolic syndrome in children and adolescents: Korean National Health and Nutrition Examination Survey
Authors: Park Jae‐Min , Lee Jee‐Yon , Lee Duk‐Chul , Lee Yong‐Jae 
Published: July 2017

AbstractAims/IntroductionSerum γ‐glutamyltransferase (GGT) is positively related to cardiometabolic diseases, such as type 2 diabetes mellitus, hypertension and metabolic syndrome (MetS), in adult populations. Our aim was to investigate whether serum GGT is independently associated with MetS and its components in a nationally representative sample of Korean children and adolescents.Materials and MethodsThe study included data from 1,618 participants (867 boys, 751 girls) aged 10–18 years from the 2010–2011 Korean National Health and Nutrition Examination Survey. MetS was diagnosed by the 2007 International Diabetes Federation criteria for children and adolescents. Participants were stratified using a cut‐off value of the 75th percentile of serum GGT levels (19 IU/L for boys, 15 IU/L for girls). The odds ratios and 95% confidence intervals for MetS and its components were determined with multiple logistic regression analyses.ResultsThe mean values of most cardiometabolic variables were significantly higher in the upper stratum. Except for low high‐density lipoprotein cholesterol in boys and elevated blood pressure in girls, participants in the upper GGT stratum had significantly higher odds of MetS and its components than those in the lower stratum. The multivariate‐adjusted odds ratios for MetS for the upper stratum were 5.79 (95% confidence interval 1.21–27.02) in boys and 6.20 (95% confidence interval 1.71–22.47) in girls, after adjusting for age, household income and residential area.ConclusionsSerum GGT was positively associated with MetS and its components in Korean children and adolescents. Serum GGT could be a useful measure for identifying children and adolescents with MetS.
The magic of the new: How job changes affect job satisfaction
Authors: Chadi Adrian , Hetschko Clemens 
Published: July 2017

AbstractWe investigate a crucial event for job satisfaction: changing one's workplace. For representative German panel data, we show that the reason why the previous employment ended is strongly linked to satisfaction with the new job. Workers initiating a change of employer experience extraordinarily high job satisfaction, though in the short term only. To investigate causality, we exploit the event of plant closure as an exogenous trigger of job switching. In this case, we find no significantly positive effect of job changes on job satisfaction. Our findings complement research on workers’ well‐being and concern labor market policies and human resource management.
Models for discovery of targeted therapy in genetic epileptic encephalopathies
Authors: Maljevic Snezana , Reid Christopher A. , Petrou Steven 
Published: July 2017

AbstractEpileptic encephalopathies are severe disorders emerging in the first days to years of life that commonly include refractory seizures, various types of movement disorders, and different levels of developmental delay. In recent years, many de novo occurring variants have been identified in individuals with these devastating disorders. To unravel disease mechanisms, the functional impact of detected variants associated with epileptic encephalopathies is investigated in a range of cellular and animal models. This review addresses efforts to advance and use such models to identify specific molecular and cellular targets for the development of novel therapies. We focus on ion channels as the best‐studied group of epilepsy genes. Given the clinical and genetic heterogeneity of epileptic encephalopathy disorders, experimental models that can reflect this complexity are critical for the development of disease mechanisms‐based targeted therapy. The convergence of technological advances in gene sequencing, stem cell biology, genome editing, and high throughput functional screening together with massive unmet clinical needs provides unprecedented opportunities and imperatives for precision medicine in epileptic encephalopathies.
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A review of available laser and intense light source home devices: A dermatologist's perspective
Authors: Juhász Margit LW , Levin Melissa K , Marmur Ellen S 
Published: July 2017

SummaryBackgroundHome optical devices are becoming an increasingly popular treatment modality sought out by patients for dermatologic pathologies such as acne, hair removal and anti‐aging, as these devices are a low‐cost and convenient therapy choice.MethodsAn Internet search using PubMed.gov was completed with search terms, “home device dermatology,” “home device acne,” “home device hair” or “hair removal,” and “home device aging.”ResultsCurrently, there are multiple home optical devices available on the market. These devices have been approved for the treatment of acne, scars, hair removal, and wrinkles using intense pulsed light, light‐emitting diode, heat, infrared, low‐level light therapy, and laser. Although studies on home devices are limited, current dermatologic literature shows that these devices are promising with significant post‐treatment results as well as a high level of safety.ConclusionsHome optical devices are mostly used without medical practitioner supervision. As home devices usually deliver less energy per session than with professional treatments, it is important that consumers are given realistic expectations of post‐treatment outcomes. Patients may use home devices without disclosure to their physician and it is important as healthcare professionals to be aware of the existence of these devices, how to use the devices properly (including what diseases can be treated and which skin types are considered safe for use), as well as any adverse effects that may occur. New research endeavors are being completed to explore the used of home devices for the treatment of chronic inflammatory diseases such as psoriasis.
Consumer's expectation of changes in fruit based on their sensory properties at purchase. The case of banana (Musa Cavendish) appearance evaluated on two occasions: Purchase and home consumption
Authors: Elizagoyen Eliana S. , Hough Guillermo , Garitta Lorena , Fiszman Susana , Bravo Vasquez Juan Eduardo 
Published: July 2017

AbstractThe objective of this work was to estimate the expectation of change in sensory properties of fruits by analyzing the different choice criteria at purchase and consumption occasions. Bananas were taken as a case study, evaluated with consumers from Argentina, Ecuador, and Spain. A set of 10 digital images of bananas ranging from totally green to overly ripe were first submitted to a trained panel to ensure there were significant differences between them on a ripening scale. These images were then presented to 300 consumers in total from Argentina, Ecuador, and Spain. Consumers assessed each image choosing between under‐ripe, ok, or over‐ripe; considering two different occasions: when purchasing the bananas and when consuming the bananas in their homes. Based on hue‐angle measurements, survival analysis statistics were applied to estimate the optimum ripening indexes (ORI). ORI for purchase occasions were lower than for home consumption occasions, that is, bananas are bought greener, with the expectation that they would ripen to the adequate stage in the period between purchase and consumption. There were also differences between the ORI estimated over the three countries. On average, Argentine consumers preferred riper bananas than Ecuador or Spanish consumers.Practical applicationsFor certain fruits, such as bananas shown in this study, consumers consciously choose or ask for a not totally ripe product with the expectation that it will reach optimum ripeness on the consumption occasion. Retail stores should consider this fact in marketing their products providing recommendations for consumers, such as “keep at room temperature and consume after 2 or 3 days”; or “we recommend you consume this melon today.” For the particular case of bananas, the current commercial chart used to estimate banana maturity based on sensory appearance would not always be adequate. This work provides a range of maturation based on consumer input, both for purchase and home‐consumption situations. These ranges could serve as a guide for retail stores that sell bananas in different countries.
A scoping review of skills and tools oral health professionals need to engage children and parents in dietary changes to prevent childhood obesity and consumption of sugar‐sweetened beverages
Authors: Mallonee Lisa F. , Boyd Linda D. , Stegeman Cynthia 
Published: July 2017

AbstractObjectivesIncreased consumption of sugar‐sweetened beverages (SSBs) has been linked to obesity. Obesity now affects one in six children in the United States. The purpose of this scoping review is to identify and review published studies that discuss skills and tools oral health professionals can use with children (under age 12) and their parents to encourage dietary changes to aid in preventing childhood obesity and reducing consumption of SSBs.MethodsKey search terms were identified and used to examine selected databases via PubMed, EMBASE, CINAHL, and Cochrane Database of Systematic Reviews. A total of 637 records were identified. After duplicates were removed and records were screened for eligibility, 33 remained. Six met established inclusion/exclusion criteria and were included in the review.ResultsOnly two full‐text articles included dental‐office‐based weight interventions. Patient response to education on healthy habits and weight maintenance in the dental setting was favorable. Literature supports oral health professionals expanding their role in health care delivery by offering nutrition and physical activity recommendations to prevent and/or reduce chronic disease. Active listening and motivational interviewing were techniques identified to promote beneficial lifestyle changes.ConclusionsThere is limited research on behavior modification tools and skills that have been effectively implemented in the dental setting to decrease risk of obesity. Oral health professionals are uniquely positioned to address consumption of SSBs and promote positive dietary habits for improved weight management. Future studies are needed to identify effective techniques that techniques that oral health professionals can integrate into preventive patient care.
Developing a Scale of Adaptive Behavior for Young Chinese Children With Autism Spectrum Disorder
Authors: Liu Chuanshi , Sun Honghuan , Wu Fuxiang , Posada Alexandria , Liu Yangyang 
Published: July 2017

ABSTRACTThe purpose of the present study was to develop and evaluate a scale to measure adaptive behavior skills in Chinese children with autism spectrum disorder (ASD). Participants were 121 young children (M = 55.18 months, SD = 0.18 months) with a formal diagnosis of ASD (73% male). Psychometric evaluation indicated that the reliability and validity of this scale were good. Furthermore, independent t‐tests revealed that boys demonstrated better adaptive behavior skills than girls. The present findings suggest that the scale is a valid measure of adaptive behavior skills in Chinese children with ASD.
Weight management strategies for those with chronic kidney disease: A consensus report from the Asia Pacific Society of Nephrology and Australia and New Zealand Society of Nephrology 2016 renal dietitians meeting
Authors: Lambert Kelly , Beer Jo , Dumont Ruth , Hewitt Katie , Manley Karen , Meade Anthony , Salamon Karen , Campbell Katrina 
Published: July 2017

Summary at a GlanceThis is a report on the discussions, at a conference meeting, among dieticians around six pertinent statements, in relation to weight management in CKD patients. Consensus, arising from the dietitians' research into the validity of these statements, is summarized and recommendations for future research is suggested.
XYLEM NAC DOMAIN1, an angiosperm NAC transcription factor, inhibits xylem differentiation through conserved motifs that interact with RETINOBLASTOMA‐RELATED
Authors: Zhao Chengsong , Lasses Theres , Bako Laszlo , Kong Danyu , Zhao Bingyu , Chanda Bidisha , Bombarely Aureliano , Cruz‐Ramírez Alfredo , Scheres Ben , Brunner Amy M. , Beers Eric P. 
Published: July 2017

Summary

The Arabidopsis thaliana gene XYLEM NAC DOMAIN1 (XND1) is upregulated in xylem tracheary elements. Yet overexpression of XND1 blocks differentiation of tracheary elements. The molecular mechanism of XND1 action was investigated.

Phylogenetic and motif analyses indicated that XND1 and its homologs are present only in angiosperms and possess a highly conserved C‐terminal region containing linear motifs (CKII‐acidic, LXCXE, E2FTD‐like and LXCXE‐mimic) predicted to interact with the cell cycle and differentiation regulator RETINOBLASTOMA‐RELATED (RBR). Protein–protein interaction and functional analyses of XND1 deletion mutants were used to test the importance of RBR‐interaction motifs.

Deletion of either the LXCXE or the LXCXE‐mimic motif reduced both the XND1–RBR interaction and XND1 efficacy as a repressor of differentiation, with loss of the LXCXE motif having the strongest negative impacts. The function of the XND1 C‐terminal domain could be partially replaced by RBR fused to the N‐terminal domain of XND1. XND1 also transactivated gene expression in yeast and plants.

The properties of XND1, a transactivator that depends on multiple linear RBR‐interaction motifs to inhibit differentiation, have not previously been described for a plant protein. XND1 harbors an apparently angiosperm‐specific combination of interaction motifs potentially linking the general differentiation regulator RBR with a xylem‐specific pathway for inhibition of differentiation.
Randomized Controlled Trial on the Influence of Intraoperative Remifentanil versus Fentanyl on Acute and Chronic Pain after Cardiac Surgery
Authors: de Hoogd Sjoerd , Ahlers Sabine J.G.M. , van Dongen Eric P.A. , van de Garde Ewoudt M.W. , Daeter Edgar J. , Dahan Albert , Tibboel Dick , Knibbe Catherijne A.J. 
Published: July 2017

AbstractBackgroundRemifentanil has been associated with increased acute and potentially chronic postoperative pain. The objective of this prospective randomized controlled trial was to investigate the influence of intraoperative remifentanil on acute and chronic postoperative pain after cardiac surgery.MethodsPatients (N = 126) receiving standardized anesthesia with propofol and intermittent intravenous fentanyl at predetermined times for cardiac surgery were randomized to intraoperatively receive either a continuous remifentanil infusion or additional intermittent intraoperative fentanyl as needed. The primary endpoint was chronic thoracic pain at 12 months after surgery. Secondary endpoints were pain at 3 and 6 months after surgery and analgesic requirements and pain levels in the first 72 hours.ResultsThere was no significant difference in incidence of chronic thoracic pain between the remifentanil and fentanyl groups, respectively (20% vs. 18%; P = 0.817). At 3 months, however, significantly more patients in the remifentanil group reported chronic thoracic pain (51% vs. 33%; P = 0.047). This effect was more pronounced in younger patients and in patients receiving a higher dose of remifentanil (both P < 0.05). The first 24 and 48 hours postoperatively, morphine consumption in the remifentanil group was significantly higher than in the fentanyl group (34.3 mg [interquartile range (IQR) 25.3 to 48.2] vs. 30.2 mg [IQR 19.2 to 38.1], P = 0.028; and 46.8 mg [IQR 33.8 to 59.2] vs. 39.0 mg [IQR 6.2 to 51.4], P = 0.047, respectively).ConclusionsIntraoperative use of remifentanil during cardiac surgery does not impact chronic postoperative pain 1 year after surgery. Nevertheless, remifentanil increases analgesic requirements and thoracic pain until 3 months after surgery, and its use is therefore less favorable during cardiac surgery.
Quantitative trait loci with additive and epistatic effects underlying resistance to two HG types of soybean cyst nematode
Authors: Han Yingpeng , Tan Yunfu , Hu Haibo , Chang Wei , Dong Limin , Wang Zizhen , Zhao Xue , Li Wenbin , Teng Weili 
Published: July 2017

AbstractThe resistance of soybean (Glycine max L. Merr.) cultivars varies with the different races of the soybean cyst nematode (SCN), Heterodera glycines, referred to as HG types (biotypes). Resistant cultivars with durable resistance are emphasized in recent years. The aim here was to identify quantitative trait loci (QTLs) for resistance to two SCN HG types (HG type 2.5.7, race 1; and HG type 1.2.3.5.7, race 4) in resistant cultivar ‘L‐10’ and to analyse the additive and epistatic effects of the identified QTLs. A total of 140 F5‐derived F10 recombinant inbred lines (F5:10 RILs) were advanced via single‐seed‐descent from the cross between ‘L‐10’ (broadly resistant to SCN) and “Heinong 37” (SCN‐susceptible). For SCN HG type 2.5.7 and HG type 1.2.3.5.7 resistance, three and six QTLs for resistance to SCN HG type 2.5.7 and HG type 1.2.3.5.7 were identified, respectively, most of which could explain <10% of the phenotypic variation. Among these QTLs, five were identified over 2 years, while the other QTLs were detected in either 2009 or 2010. QSCN1‐2, located near the SSR marker Sat_069 of linkage group D1b (Chromosome, 2), was responsible for the largest proportion of phenotypic variation (16.01% in 2009 and 18.94% in 2010), suggested that it could effectively be used as a candidate QTL for the marker‐assisted selection (MAS) of soybean lines resistant to SCN. Additionally, for SCN HG type 2.5.7 and HG type 1.2.3.5.7 resistance, two and four QTLs showed an additive effect (a), respectively. One epistatic pair of QTLs (QSCN1‐1‐QSCN1‐3) for SCN HG type 2.5.7 resistance and eight epistatic pairs of QTLs for SCN HG type 1.2.3.5.7 resistance were found to have significant aa effects, among which one pair of QTLs (QSCN4‐4 and QSCN4‐5) contributed a large proportion of aa effects (3%). The results indicated that additive and epistatic effects could significantly affect SCN resistance. Therefore, both of a and aa effects should be considered in MAS programmes.
Age‐dependent regulation of ERF‐VII transcription factor activity in Arabidopsis thaliana
Authors: Giuntoli Beatrice , Shukla Vinay , Maggiorelli Federica , Giorgi Federico M. , Lombardi Lara , Perata Pierdomenico , Licausi Francesco 
Published: July 2017

AbstractThe Group VII Ethylene Responsive Factors (ERFs‐VII) RAP2.2 and RAP2.12 have been mainly characterized with regard to their contribution as activators of fermentation in plants. However, transcriptional changes measured in conditions that stabilize these transcription factors exceed the mere activation of this biochemical pathway, implying additional roles performed by the ERF‐VIIs in other processes. We evaluated gene expression in transgenic Arabidopsis lines expressing a stabilized form of RAP2.12, or hampered in ERF‐VII activity, and identified genes affected by this transcriptional regulator and its homologs, including some involved in oxidative stress response, which are not universally induced under anaerobic conditions. The contribution of the ERF‐VIIs in regulating this set of genes in response to chemically induced or submergence‐stimulated mitochondria malfunctioning was found to depend on the plant developmental stage. A similar age‐dependent mechanism also restrained ERF‐VII activity upon the core‐hypoxic genes, independently of the N‐end rule pathway, which is accounted for the control of the anaerobic response. To conclude, this study shed new light on a dual role of ERF‐VII proteins under submergence: as positive regulators of the hypoxic response and as repressors of oxidative‐stress related genes, depending on the developmental stage at which plants are challenged by stress conditions.
Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)‐ and/or N(9)‐methyl‐β‐carboline Derivatives
Authors: Rasse‐Suriani Federico A. O. , García‐Einschlag Fernando S. , Rafti Matías , Schmidt De León Tobías , David Gara Pedro M. , Erra‐Balsells Rosa , Cabrerizo Franco M. 
Published: July 2017

AbstractIn the present work, we have synthesized and fully characterized the photophysical and photochemical properties of a selected group of N‐methyl‐β‐carboline derivatives (9‐methyl‐β‐carbolines and iodine salts of 2‐methyl‐ and 2,9‐dimethyl‐β‐carbolinium) in aqueous solutions, in the pH range 4.0–14.5. Moreover, despite the quite extensive studies reported in the literature regarding the overall photophysical behavior of N‐unsubstituted βCs, this work constitutes the first full and unambiguous characterization of anionic species of N‐unsubstituted βCs (norharmane, harmane and harmine), present in aqueous solution under highly alkaline conditions (pH > 13.0). Acid dissociation constants (Ka), thermal stabilities, room temperature UV–visible absorption and fluorescence emission and excitation spectra, fluorescence quantum yields (ФF) and fluorescence lifetimes (τF), as well as quantum yields of singlet oxygen production (ФΔ) have been measured for all the studied compounds. Furthermore, for the first time to our knowledge, chemometric techniques (MCR‐ALS and PARAFAC) were applied on these systems, providing relevant information about the equilibria and species involved. The impact of all the foregoing observations on the biological role, as well as the potential biotechnological applications of these compounds, is discussed.