bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of externalisation in recovery from Anorexia Nervosa: a reflexive thematic analysis
Authors: Cripps Sophie , Pugh Matthew , Serpell Lucy 
Published: October 2024

Abstract
Background
Many individuals perceive Anorexia Nervosa (AN) as a part of their personal identity. Externalisation of the problem is a practice that is often taken up within NICE recommended treatments for AN. Dominant understandings of externalisation are that this practice involves making the “problem” a separate entity, external to the individual. It is an attitude taken by the client and family, stimulated by the therapist to build engagement with treatment and supportive relationships around the individual. However, there is a paucity of research exploring the therapeutic effects of this approach. This research aims to address this gap by exploring the role of externalisation in treatment for AN to elicit an understanding of how this practice is experienced including how it can help and hinder recovery.

Methods
Thirteen adults with a current and/or past diagnosis of AN participated in semi-structured interviews. This qualitative study used a reflexive thematic analysis.

Analysis
Participants described their experience of externalisation as a journey which is depicted by four main themes. ‘Separating the AN from the self’ reflects the tensions inherent in learning to distinguish between one’s perceived sense of "self" and "the AN". ‘Making sense of the AN’ describes the experience of language forms used to separate the AN from the individual’s identity. ‘Feeling seen, or unseen as a person beyond the AN’ illustrates the helpful and harmful effects of externalising practices on relationships. ‘Navigating a complex relationship with the AN’ depicts the effects of one-, versus two-way externalisation on the individual’s relationship to AN.

Conclusions
The notion of separating one’s internal dialogue from one’s concept of self may initially be rejected by the individual experiencing AN. However, as the individual develops trust in the therapist and becomes socialised to common forms of externalising language, they may begin to realise two sides within them, a perceived “healthy self” and “the anorexia voice”. However, social-cultural discourses around eating contribute to ambiguity during the differentiation between these two voices, thus elucidating the effects of an absence of problem deconstruction alongside externalisation within ED-focussed treatments. Externalising practices were most helpful when led by the individual using their own experience-near language and least helpful when they did not permit the individual to feel seen as a person beyond the AN. Therapists, treatment teams and family members should be cognisant of the emotional effects of language used to externalise AN. Importantly, they should ensure that externalisation is practiced within the spirit of narrative therapy from which it originates.
A mechanism study of type i corrosion on the surface of ancient tin rich bronzes
Authors: Jiang Xudong , Zhang Jun , Huang Feng , Xie Haijiao , Li Qi , Fang Chen 
Published: October 2024

Abstract
This study compares the surface patina of ancient tin rich bronze with pure hydrothermally synthesized SnO2 nanoparticles using various analytical techniques, including metallographic microscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and high-angle annular dark-field scanning transmission electron microscopy. The primary crystalline component of the patina consists of approximately 5 nm SnO2 nanoparticles, which closely resemble pure SnO2, indicating their comparability. Cu was also detected in the patina; however, it did not form crystalline structures. The X-ray diffraction results showed a shift in the patina’s peak, suggesting the infiltration of Cu into the SnO2 lattice, which compromises its crystallinity. In comparison to synthetic SnO2, the X-ray photoelectron spectroscopy spectra of the patina revealed novel peaks corresponding to both Cu and O, indicating the presence of Cu−O−Sn bonding—a characteristic feature of type-I patina. This suggests that the primary structure of type-I patina consists of crystalline SnO2 nanoparticles, with a limited amount of Cu integrated into its lattice configuration. The concentration of Cu within the SnO2 crystal units is restricted, leading primarily to the formation of amorphous Cu2O in conjunction with Sn. The presence of Sn enhances the structural stability of Cu2O, facilitating its incorporation while inhibiting the crystallization of Cu2O. However, when the Sn concentration is insufficient, an inadequate Cu–O−Sn amorphous phase may form, allowing for the potential crystallization of Cu2O.
Characterization of argonaute nucleases from mesophilic bacteria Pseudobutyrivibrio ruminis
Authors: Xu Xiaoyi , Yang Hao , Dong Huarong , Li Xiao , Liu Qian , Feng Yan 
Published: October 2024

AbstractMesophilic Argonautes (Agos) from microbial resources have received significant attention due to their potential applications in genome editing and molecular diagnostics. This study characterizes a novel Ago from Pseudobutyrivibrio ruminis (PrAgo), which can cleave single-stranded DNA using guide DNA (gDNA). PrAgo, functioning as a multi-turnover enzyme, effectively cleaves DNA using 5′-phosphate gDNA, 14–30 nucleotides in length, in the presence of both Mn2+ and Mg2+ ions. PrAgo demonstrates DNA cleavage activity over a broad pH range (pH 4–12), with optimal activity at pH 11. As a mesophilic enzyme, PrAgo cleaves efficiently DNA at temperatures ranging from 25 to 65 °C, particularly at 65 °C. PrAgo does not show strong preferences for the 5′-nucleotide in gDNA. It shows high tolerance for single-base mismatches, except at positions 13 and 15 of gDNA. Continuous double-nucleotide mismatches at positions 10–16 of gDNA significantly reduce cleavage activity. Furthermore, PrAgo mediates DNA-guided DNA cleavage of AT-rich double stranded DNA at 65 °C. Additionally, molecular dynamic simulations suggest that interactions between the PAZ domain and different nucleic acids strongly influence cleavage efficiency. These findings expand our understanding of Protokaryotic Agos and their potential applications in biotechnology.
Graphical Abstract
New frontiers in domain-inspired radiomics and radiogenomics: increasing role of molecular diagnostics in CNS tumor classification and grading following WHO CNS-5 updates
Authors: Singh Gagandeep , Singh Annie , Bae Joseph , Manjila Sunil , Spektor Vadim , Prasanna Prateek , Lignelli Angela 
Published: October 2024

AbstractGliomas and Glioblastomas represent a significant portion of central nervous system (CNS) tumors associated with high mortality rates and variable prognosis. In 2021, the World Health Organization (WHO) updated its Glioma classification criteria, most notably incorporating molecular markers including CDKN2A/B homozygous deletion, TERT promoter mutation, EGFR amplification, + 7/−10 chromosome copy number changes, and others into the grading and classification of adult and pediatric Gliomas. The inclusion of these markers and the corresponding introduction of new Glioma subtypes has allowed for more specific tailoring of clinical interventions and has inspired a new wave of Radiogenomic studies seeking to leverage medical imaging information to explore the diagnostic and prognostic implications of these new biomarkers. Radiomics, deep learning, and combined approaches have enabled the development of powerful computational tools for MRI analysis correlating imaging characteristics with various molecular biomarkers integrated into the updated WHO CNS-5 guidelines. Recent studies have leveraged these methods to accurately classify Gliomas in accordance with these updated molecular-based criteria based solely on non-invasive MRI, demonstrating the great promise of Radiogenomic tools. In this review, we explore the relative benefits and drawbacks of these computational frameworks and highlight the technical and clinical innovations presented by recent studies in the landscape of fast evolving molecular-based Glioma subtyping. Furthermore, the potential benefits and challenges of incorporating these tools into routine radiological workflows, aiming to enhance patient care and optimize clinical outcomes in the evolving field of CNS tumor management, have been highlighted.
The Jan Sjödin faba bean mutant collection: morphological and molecular characterization
Authors: Khazaei Hamid , Carlson-Nilsson Ulrika , Schulman Alan H. 
Published: October 2024

Abstract
Background
Plant mutagenesis creates novel alleles, thereby increasing genetic and phenotypic diversity. The availability of the faba bean (Vicia faba L.) reference genome and a growing set of additional genomic resources has increased the scientific and practical value of mutant collections. We aimed to genotype and morphologically phenotype a historical faba bean mutant collection developed and characterized by Jan Sjödin (1934–2023) over half a century ago in order to increase its value to researchers. The collection was genotyped using high-throughput single-primer enrichment technology (SPET) assays.

Results
We used 11,073 informative single nucleotide polymorphism (SNP) markers spanning the faba bean genome to genotype 52 mutant lines along with the background line, cv. Primus. A range of flower, seed, leaf, and stipule mutations were observed. The analysis of population structure revealed a shallow structure with no major subpopulations. Principal component and cluster analyses revealed, to a minor extent, that the mutants clustered by their phenotype.

Conclusions
The mutants’ phenotypic variation and shallow structure indicate that the Sjödin faba bean collection has the potential to play a significant role in faba bean breeding and in genetic and functional studies.
Evaluation of alternative methods for forecasting the Aboriginal and Torres Strait Islander population of Australia
Authors: Wilson Tom , Temple Jeromey , Burchill Luke , Luke Jo , Logiudice Dina 
Published: October 2024

AbstractAssessing future demand for a wide range of services requires good quality population forecasts. Unfortunately, many past forecasts of the Aboriginal and Torres Strait Islander (Indigenous) population of Australia have proved highly inaccurate. This is due to poor data quality, missing data, and demographers’ incomplete understanding of Indigenous population change. In addition, because Indigenous population estimates are published only every 5 years and long after the reference date, forecasts are often used as preliminary population estimates. These form the denominators of various metrics used to monitor programmes aimed at improving health and social outcomes. The aim of this paper is to present an evaluation of alternative forecasting models and forecasts of the Indigenous population of Australia’s States and Territories by age and sex. Four models, differing substantially in complexity, were evaluated: (1) the simple Hamilton–Perry method, (2) the synthetic migration cohort-component model, (3) a uniregional cohort-component model with net migration, and (4) a bi-regional cohort-component model. The population forecasting methods were evaluated against several criteria, including forecast accuracy over the 2016–21 period, input data requirements, conceptual adequacy, output detail, time required to prepare, ability to create scenarios and select alternative assumptions, and ease of implementation. The Hamilton–Perry and synthetic migration cohort-component models provided greater forecast accuracy and scored well against the evaluation criteria. In the challenging data environment for modelling Indigenous populations, simpler forecasting methods offer several practical advantages and are likely to produce more accurate forecasts than more data-intensive models.
Prognostic significance of pretreatment PET parameters in inoperable, node-positive NSCLC patients with poor prognostic factors undergoing hypofractionated radiotherapy: a single-institution retrospective study
Authors: Zinn Annemarie Barbara , Kenndoff Saskia , Holzgreve Adrien , Käsmann Lukas , Guggenberger Julian Elias , Hering Svenja , Mansoorian Sina , Schmidt-Hegemann Nina-Sophie , Reinmuth Niels , Tufman Amanda , Dinkel Julien , Manapov Farkhad , Belka Claus , Eze Chukwuka 
Published: October 2024

Abstract
Background
Node-positive non-small cell lung cancers (NSCLCs) present a challenge for treatment decisions, particularly in patients ineligible for concurrent chemoradiotherapy (CRT) due to poor performance status and compromised lung function. We aimed to investigate the prognostic value of pretreatment positron emission tomography (PET) parameters in high-risk patients undergoing hypofractionated radiotherapy.

Methods
A retrospective analysis was conducted on 42 consecutive patients with inoperable node-positive NSCLC, who underwent hypofractionated radiotherapy between 2014 and 2021 at a single institution. Clinical, treatment-related, and [18F]FDG PET-based parameters were correlated with progression-free survival (PFS) and overall survival (OS). Median dichotomisation was performed to establish risk groups. Statistical analyses included univariable and multivariable Cox regression and Kaplan-Meier survival analyses.

Results
After a median follow-up of 47.1 months (range: 0.5-101.7), the median PFS and OS were 11.5 months (95% CI: 7.4-22.0), and 24.3 months (95% CI: 14.1-31.8). In univariable Cox regression analysis, significant predictors of PFS included receipt of salvage systemic treatment (p=0.007), SUVmax (p=0.032), and tMTV (p=0.038). Similarly, ECOG-PS (p=0.014), Histology (p=0.046), and tMTV (p=0.028) were significant predictors of OS. Multivariable Cox regression analysis (MVA) identified SUVmax as a significant predictor for PFS [HR: 2.29 (95% CI: 1.02-5.15); p=0.044]. For OS, ECOG-PS remained a significant prognosticator [HR: 3.53 (95% CI: 1.49-8.39); p=0.004], and tMTV approached significance [HR: 2.24 (95% CI: 0.95-5.26); p=0.065]. Furthermore, the high tMTV group exhibited a median PFS of 5.3 months [95% CI: 2.8-10.4], while the low tMTV group had a PFS of 15.2 months [95% CI: 10.1-33.5] (p=0.038, log-rank test). Median OS was 33.5 months [95% CI: 18.3-56.8] for tMTV ≤ 36.6 ml vs. 14.1 months [95% CI: 8.1-27.2] for tMTV > 36.6 ml (p=0.028, log-rank test).

Conclusion
Pretreatment PET parameters, especially tMTV, hold promise as prognostic indicators in NSCLC patients undergoing hypofractionated radiotherapy. The study highlights the potential of PET metrics as biomarkers for patient stratification.
Health benefits and functions of salt-fermented fish
Authors: Cha Yong-Jun , Yu Daeung 
Published: October 2024

AbstractSalt-fermented fish, a typical food in many regions of the world, was classified into three types depending on the processing method. It was divided into a process of fermenting by adding fish and salt only, a method of filtering it to form a fish sauce, and a method of lactic acid fermenting by adding additional carbohydrates. The free amino acids produced in large quantities through fermentation make salt-fermented fish a valuable protein source in regions where rice is the staple food. Furthermore, they also have significant amounts of omega-3 fatty acids (EPA and DHA), making them nutritionally excellent and functional, with antioxidant, antihypertensive, and fibrinolytic activities that benefit cardiovascular health. Some lactic acid bacteria (LAB) isolated from fermented fish products have beneficial effects on humans, including bacteriocin and probiotic effects. Looking to the future, the potential benefits of reducing naturally occurring biogenic amines and adjusting the salt content for storage stability could further enhance the health and taste benefits of salt-fermented fish, providing hope and optimism for the future of food preservation and nutrition.
Nuclear factor kappa B 1 A > G single-nucleotide polymorphism (rs4648068) in Egyptian patients with Behcet’s syndrome, case–control study
Authors: Saad Moustafa Ali , El Gendy Hala Ibrahem , Laymouna Ahmed Hatem , Shaker Olfat , Behiry Mervat Essam 
Published: October 2024

Abstract
Background
Behcet's syndrome (BS) is a variable-vessel vasculitis characterized by hyperactive innate immunity. The nuclear factor kappa B (NFKB) pathway is involved in the regulation of inflammatory responses including innate and adaptive immune responses. BS could be associated with NFKB hyperactivation. We aimed to study the association between the NFKB1 A > G (rs4648068) single-nucleotide polymorphism (SNP) and BS in Egyptian patients, in comparison to healthy controls, and to correlate the presence of rs4648068 SNP with the different activity domains of the disease. After ethical committee approval (Faculty of Medicine, Cairo University, Egypt, code MD-228-2022), the International Study Group Criteria for Behçet's Disease (ISG) criteria was used to recruit 60 BS patients, and the activity of the disease was assessed using Behcet’s Disease Current Activity Form (BDCAF) and the Behcet Syndrome Activity Score (BSAS). Another 60 matched controls were recruited. DNA extraction was done followed by PCR amplification to detect the target SNP.

Results
The GG genotype was significantly higher in BS versus controls (21.7% and 5%, respectively, p value = 0.015). Also, the G allele was significantly higher in BS versus controls (43.3% and 30%, respectively, p value = 0.033). Of the whole activity domains, only arthralgia was found to be significantly correlated with rs4648068 SNP.

Conclusion
NFKB1 rs4648068 A > G SNP increases the risk of developing BS. Among patients with BS, the GG genotype is protective against developing arthralgia. There is no statistically significant relation between rs4648068 SNP and either other activity domains of BS or the different activity scores of the disease.
Role of Ihh — a progesterone-responsive gene in mammalian reproduction: a review
Authors: Saikia Archana , Sarma Hirendra Nath 
Published: October 2024

Abstract
Indian hedgehog (Ihh) is a member of the developmentally regulated morphogens, the hedgehog gene family. The Hh protein family was initially discovered in Drosophila and has since been widely investigated in both Drosophila and higher animals. Ihh exhibited a dynamic spatiotemporal expression pattern in the mammalian uterus and ovaries. The downstream targets of the Ihh signaling pathway include PTCH-1, SMO, and COUP-TFII. Ihh is a progesterone-responsive gene that plays an important function in the female reproductive system; conditional ablation results in infertility due to failed embryo implantation. The literature addressing Ihh’s functions and ways of action is expanding, as is the number of processes that use it in cell signaling as well as physiology. Even while our grasp of the path has expanded tremendously, we still have many gaps in our knowledge. This review will address the discovery, evolution, mechanisms, and manifestations of Ihh especially in mammalian reproduction.
Provision of digital health interventions for young people with ADHD in primary care: findings from a survey and scoping review
Authors: Gudka Rebecca , Becker Kieran , Newlove-Delgado Tamsin , Price Anna 
Published: October 2024

Abstract
Background
People with attention-deficit hyperactivity disorder (ADHD) are at risk of negative health outcomes, with risks reduced through evidence-based treatments. Therefore, ensuring continued access to treatment for young people with ADHD, especially as they transition from child to adult services, is a priority. Currently many young people with ADHD are unable to access adequate care, with negative consequences for patients and their communities. Preliminary evidence suggests digital health interventions (DHIs) may act as an effective adjunct to usual care, helping overcome barriers to access, and improving outcomes by increasing understanding of ADHD as a long-term condition. The aim of this mixed methods study is to explore the healthcare information preferences of people with lived experience of ADHD in the primary care context and considers these in the light of the emerging body of literature on DHIs for ADHD. To explore this, a descriptive summary of cross-sectional survey responses was compared and discussed in the context of DHIs identified in a scoping review.

Results
Digital apps, followed by support groups, were deemed the most useful information resource types by survey respondents, but were the least currently used/provided. Over 40% participants indicated a preference for signposting to all resource types by their general practitioner (GP), suggesting that GPs are credible sources for ADHD healthcare information. The scoping review identified nine studies of DHI for ADHD, consisting of games, symptom monitoring, psychoeducation, and medication reminders, with limited evidence of effectiveness/implementation.

Conclusions
People with ADHD state a preference for digital apps as an adjunct to usual care. However, these are currently the least provided information resource in primary care, indicating a key area for future development. The limited evidence base on DHIs for ADHD suggests combining digital apps and support networks, and utilising multimodal delivery methods may also enhance the delivery of healthcare information.
Thoracic Radiotherapy Improves the Survival in Patients With
EGFR
-Mutated Oligo-Organ Metastatic Non–Small Cell Lung Cancer Treated With Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitors: A Multicenter, Randomized, Controlled, Phase III Trial
Authors: Sun Hongfu , Li Minghao , Huang Wei , Zhang Jian , Wei Shihong , Yang Yongjing , Wang Zhongtang , Ye Shucheng , Gong Heyi , Zhang Yaowen , Li Jie , Song Haixia , Wang Lifang , Chen Xiangming , Lin Haiqun , Ding Gaofeng , Li Hongwei , Zheng Anping , Ma Xuezhen , Chen ShaoShui , Liu Liping , Zhang Kaixian , Fu Chengrui , Liu Wenzhi , Wang Jing , Zhang Xiaqin , Liu Tingting , Han Dan , Zhao Qian , Wu Peipei , Yuan Qianqian , Tian LiJun , Zhang Ping , Wu Xueqin , Chen Fei , Zhang Zicheng , Li Baosheng 
Published: October 2024

PURPOSE

This multicenter, randomized, phase III clinical trial (Northern Radiation Oncology Group of China-002) focused on patients with oligo-organ metastatic non–small cell lung cancer (NSCLC) who have epidermal growth factor receptor (
EGFR
) mutations. We aimed to investigate whether first-line concurrent thoracic radiotherapy (TRT) and EGFR-tyrosine kinase inhibitors (TKIs), compared with TKIs alone, could achieve better survival.

MATERIALS AND METHODS
The patients in the TKI plus TRT group received 60 Gy to primary lung tumor and positive regional lymph nodes. Radiotherapy for metastases to other sites was determined by clinicians. The primary end point was the progression-free survival (PFS). Secondary end points included overall survival (OS) and treatment-related adverse events (TRAEs). The first and second interim analyses were performed in March 2021 and March 2022.

RESULTS

Between April 14, 2016, and February 25, 2022, a total of 118 patients were enrolled. Compared with the TKI alone group, the TKI plus TRT group achieved significantly better PFS (hazard ratio [HR], 0.57;
P
= .004) and OS (HR, 0.62;
P
= .029). The median PFS was 10.6 months in the TKI alone group and 17.1 months in the TKI plus TRT group. The median OS was 26.2 months and 34.4 months in the TKI alone group and TKI plus TRT group, respectively. The TKI plus TRT group showed better local control but was associated with a higher incidence of severe TRAEs (11.9%
v
5.1%).

CONCLUSION

For patients with
EGFR
-mutated oligo-organ metastatic NSCLC treated with first-line EGFR-TKIs, concurrent TRT improves the PFS and OS, and TRAEs are acceptable and tolerable.