bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-based difference in Achilles peritendinous levels of matrix metalloproteinases and growth factors after acute resistance exercise
Authors: Astill Broc D. , Katsma Mark S. , Cauthon David J. , Greenlee Jason , Murphy Mark , Curtis Donald , Carroll Chad C. 
Published: November 2016

Several recent investigations have demonstrated that the ability of various tendons to alter structural and functional properties in response to exercise are muted in women compared with men. We hypothesize that this disparity between men and women may be due to a reduced tendon production of key mediators of tendon extracellular matrix (ECM) remodeling in response to mechanical loading, e.g., exercise. Using microdialysis before and after an acute bout of resistance exercise, we evaluated Achilles peritendinous levels of insulin-like growth factor-1 (IGF-1) and interleukin-6 (IL-6), which have both been shown to increase tendon collagen synthesis. Additionally, the matrix remodeling enzymes matrix metalloproteinase-2 (MMP-2), MMP-9, and tissue inhibitor of metalloproteinase-1 (TIMP-1) were also evaluated. IGF-1 levels were elevated ( P < 0.05) to a similar extent in men and women after 3 h of exercise but remained elevated at 4 h in only women. IL-6 levels were ~4-fold greater after exercise in both men and women ( P < 0.05). MMP-2 levels increased to a similar extent (~2-3-fold) in men and women ( P < 0.05). In contrast, MMP-9 increased with exercise but only in men ( P < 0.05). Last, TIMP-1 levels also increased ( P < 0.05) with exercise in men and women but the increase was more prolonged in women. In conclusion, we observed modest sex differences in tendon release of MMP-9, TIMP-1, and IGF-1 after acute resistance exercise. If such differences persist throughout a chronic exercise training, they may contribute to the reduced ability of women to adapt to exercise compared with men.NEW & NOTEWORTHY In this investigation we utilized microdialysis of the peritendinous Achilles to evaluate potential differences between men and women in tendon production of key regulators of extracellular matrix remodeling. We demonstrate that a modest sex-specific difference exists in peritendinous levels of several key extracellular matrix modulators after an acute bout of resistance exercise.
Alguns princípios gerais de conservação de moedas e o processo de limpeza mecânica adotado no Museu Histórico Nacional
Authors: Vieira Rejane Maria Lobo 
Published: November 2016

O texto apresenta uma coletânea de procedimentos técnicos relativos à limpeza e conservação de moedas metálicas e que resultaram de experiências bem sucedidas realizadas com o acervo do Museu Histórico Nacional, Rio de Janeiro.
Des-En-terrando achados: vistas sobre a África das diásporas
Authors: Salum Marta Heloísa Leuba 
Published: November 2016

Neste artigo apresentamos considerações sobre o uso da iconografia etnológica na abordagem da cultura material da África, a partir de pesquisas que temos realizado sobre as coleções museológicas do MAE/USP e Museu Paraense Emílio Goeldi-MPEG/MTCI. Tais considerações emergiram diante de certos objetos africanos relacionados a contextos negro-africanos no Brasil, mas concernem especialmente a estudos sobre formas e grafismos típicos das artes de sociedades de línguas bantu da África central, do final do século XIX à metade do século XX. Apontamos para a prudência com que essa iconografia, grafismos e formas devem ser tratados quando de sua aplicação como fonte de pesquisa.
Caracterização de um perfil de solo desenvolvido no sambaqui fluvial Moraes, município de Miracatu – SP
Authors: Teixeira Wenceslau Geraldes , Plens Cláudia Regina , Macedo Rodrigo Santana , Figuti Levy 
Published: November 2016

Escavações arqueológicas desenvolvidas no sambaqui fluvial Moraes, no município de Miracatu, SP, revelaram distintas camadas arqueológicas que resultaram na configuração monticular deste sítio. Com o objetivo de discutir o processo formativo deste sítio, foram realizadas análises físico-químicas do solo de dentro e de fora do mesmo para a compreensão das propriedades que podem ter contribuído para a caracterização das particularidades encontradas nas camadas arqueológicas deste sambaqui fluvial. Foi constatada uma elevada alteração em alguns parâmetros físicos e químicos dos diferentes horizontes do solo desenvolvido no sambaqui. Em especial os elevados teores de fósforo corroboram um enriquecimento deste ambiente em resíduos antrópicos ricos neste elemento (e.g. ossos). Os horizontes escuros também mostram elevados teores de carbono em relação ao perfil testemunho. Entretanto, ainda não está claro se a estabilização do carbono nos sambaquis se deve à estabilização do cálcio ou efeito de calor (carbono pirogênico) e precisará ser elucidado em próximos estudos.
Liturgia monetária em Cirene no século IV a.C.
Authors: Puccini Daniela 
Published: November 2016

É um lugar-comum nos estudos numismáticos, considerar que os nomes de personagens presentes nas moedas gregas eram de magistrados encarregados da produção monetária nas diversas polis. Este artigo apresenta uma síntese da pesquisa empreendida no âmbito de um doutorado em Arqueologia e História, que propõe discutir a função que estes personagens desempenharam na cunhagem de Cirene em período clássico a partir do cruzamento entre documento numismático e epigráfico e o levantamento do contexto histórico-arqueológico em que as moedas foram produzidas. Irregularidades na análise de ligação de cunhos, que atestam a contemporaneidade das emissões, sinalizam que estes nomes não obedeciam a uma sucessão de magistrados no cargo em intervalos regulares e reforçam a hipótese de que se tratavam de doadores de metal para a produção monetária da pólis.
Metodologia para análise tecnológica em cristais de quartzo.
Authors: Bassi Luis Felipe 
Published: November 2016

O tema deste artigo foi discutido na dissertação de mestrado sobre a análise tecnológica do cristal de quartzo proveniente do sítio arqueológico Bibocas II, em Jequitaí/MG (Bassi, 2012). Pela avaliação dos ângulos entre as facetas naturais do cristal, identificam-se elementos importantes dos processos de lascamento, de modo que o método proposto permite localizar a lasca no suporte/núcleo e mapear possíveis métodos de lascamento.
Arqueologia na floresta: contribuição metodológica da pesquisa na Floresta Nacional Tapirapé-Aquiri – FLONATA, área do Salobo, Pará
Authors: Silveira Maura Imazio da , Rodrigues Maria Christina Leal F. , Oliveira Elisangela R. de , Losier Louis-Martin 
Published: November 2016

Este artigo apresenta a metodologia de salvamento arqueológico empregada no resgate de sítios localizados em área de floresta tropical situada no sudeste do estado do Pará, município de Marabá. A delimitação sistemática através de tradagens em malha com intervalos equidistantes entre 10 m e 1 m, aliada a escavações por níveis naturais nas áreas centrais e periféricas dos sítios arqueológicos, possibilitaram a observação de processos de continuidade e descontinuidade na ocupação dos assentamentos e da formação da Terra Preta Arqueológica, aqui relacionada a áreas de atividade dentro das aldeias. A metodologia aplicada demonstrou a viabilidade de pesquisas sistemáticas em áreas com densa cobertura vegetal, assim como a análise crítica de seus alcances e limites. Os 22 sítios arqueológicos pesquisados forneceram informações que auxiliaram no entendimento da história de ocupação desta área, iniciada há 6.000 anos. Essas informações abrangem dados sobre a implantação dos sítios na paisagem, tipologia funcional dos assentamentos (habitação e acampamento) e cronologias de ocupação (inter e intra-sítios). Este trabalho contribuirá ainda na construção do conhecimento da ocupação pré-história local e regional.
Objetos, paisagens e patrimônio: introdução
Authors: Plens Claudia R. 
Published: November 2016

Este projeto de inventário do patrimônio de Guarulhos, embora traga uma longa pesquisa e múltiplas e profundas discussões, é apenas o gatilho inicial de um projeto que não se acaba em si, mas que instiga e permite o desenvolvimentode diversos projetos sobre arqueologia, história, cultura, patrimônio e memória pordiferentes agentes da sociedade civil e entidades pública e privada.Quanto à proteção e conservação do patrimônio cultural, como discutido no artigoprimeiro e nono, esta depende, sobretudo, das práticas que a própria sociedade gera em torno de seu patrimônio e da relação da sociedade em seus distintos segmentos sociais.
Patrimônio e inventário: a escolha do objeto
Authors: Plens Claudia R. , Francisco Gilberto Da Silva 
Published: November 2016

Este artigo tem como premissa a discussão de como a sociedade do presente lida com as questões patrimoniais, desde a eleição dos objetos até as consequências das escolhas no saber e gerenciamento do patrimônio. Para tanto trata os conceitos patrimoniais para depois considerar seus usos, tanto para os tomadores de decisão sobre o patrimônio quanto para a população a quem, de fato, interessa a existência de medidas protetoras de patrimônio. Essa discussão nos dará a base para discutir o modo como a população lida com seus objetos e para a possibilidade de práticas de ações conjuntas com maior justiça e ética entre sociedade civil e órgãos governamentais no que diz respeito ao patrimônio da sociedade.
Terras, ouro e cativeiro: a ocupação do aldeamento dos Guarulhos nos séculos XVI e XVII.
Authors: Vilardaga José Carlos 
Published: November 2016

Neste texto – apoio documental e do campo da história social ao trabalho de investigação arqueológica da região de Guarulhos (PIPAG) – analisa-se a expansão e ocupação colonial no território que configuraria mais tarde o município guarulhense. Centrada nos séculos XVI e XVII, a pesquisa busca acompanhar o assentamento de colonos em datas e sesmarias, e as formas de transmissão dessas propriedades entre algumas poucas famílias. Investiga as formas de beneficiamento dessas terras, dentre elas a produção agrícola, criação pastoril e principalmente a mineração de ouro, essa última, atividade fundamental na exploração do território e pouco analisada na historiografia. Por fim, o texto discute as interações estabelecidas entre os colonos e os índios, assentados no aldeamento de Nossa Senhora da Conceição dos Guarulhos e imediações, problematizando as formas de agência indígena.
Heart Failure Stages Among Older Adults in the Community
Authors: Shah Amil M. , Claggett Brian , Loehr Laura R. , Chang Patricia P. , Matsushita Kunihiro , Kitzman Dalane , Konety Suma , Kucharska-Newton Anna , Sueta Carla A. , Mosley Thomas H. , Wright Jacqueline D. , Coresh Joseph , Heiss Gerardo , Folsom Aaron R. , Solomon Scott D. 
Published: November 2016

Background:
Although heart failure (HF) disproportionately affects older adults, little data exist regarding the prevalence of American College of Cardiology/American Heart Association HF stages among older individuals in the community. Additionally, the role of contemporary measures of longitudinal strain and diastolic dysfunction in defining HF stages is unclear.

Methods:
HF stages were classified in 6118 participants in the Atherosclerosis Risk in Communities study (67–91 years of age) at the fifth study visit as follows: A (asymptomatic with HF risk factors but no cardiac structural or functional abnormalities), B (asymptomatic with structural abnormalities, defined as left ventricular hypertrophy, dilation or dysfunction, or significant valvular disease), C1 (clinical HF without prior hospitalization), and C2 (clinical HF with earlier hospitalization).

Results:

Using the traditional definitions of HF stages, only 5% of examined participants were free of HF risk factors or structural heart disease (Stage 0), 52% were categorized as Stage A, 30% Stage B, 7% Stage C1, and 6% Stage C2. Worse HF stage was associated with a greater risk of incident HF hospitalization or death at a median follow-up of 608 days. Left ventricular (LV) ejection fraction was preserved in 77% and 65% in Stages C1 and C2, respectively. Incorporation of longitudinal strain and diastolic dysfunction into the Stage B definition reclassified 14% of the sample from Stage A to B and improved the net reclassification index (
P
=0.028) and integrated discrimination index (
P
=0.016). Abnormal LV structure, systolic function (based on LV ejection fraction and longitudinal strain), and diastolic function (based on e’, E/e’, and left atrial volume index) were each independently and additively associated with risk of incident HF hospitalization or death in Stage A and B participants.

Conclusions:
The majority of older adults in the community are at risk for HF (Stages A or B), appreciably more compared with previous reports in younger community-based samples. LV ejection fraction is robustly preserved in at least two-thirds of older adults with prevalent HF (Stage C), highlighting the burden of HF with preserved LV ejection fraction in the elderly. LV diastolic function and longitudinal strain provide incremental prognostic value beyond conventional measures of LV structure and LV ejection fraction in identifying persons at risk for HF hospitalization or death.
Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study
Authors: Al‐Naamani Nadine , Chirinos Julio A. , Zamani Payman , Ruthazer Robin , Paulus Jessica K. , Roberts Kari E. , Barr R. Graham , Lima Joao A. , Bluemke David A. , Kronmal Richard , Kawut Steven M. 
Published: November 2016

Background

Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (
RV
) is unknown.

Methods and Results

The associations between systemic arterial measures (total arterial compliance [
TAC
], systemic vascular resistance [
SVR
], and aortic augmentation index [
AI
]) and
RV
morphology (mass, end‐systolic [
RVESV
] and end‐diastolic volume [
RVEDV
], and ejection fraction [
RVEF
]) were examined using data from the Multi‐Ethnic Study of Atherosclerosis. All analyses were adjusted for anthropometric, demographic, and clinical variables and the corresponding left ventricular parameter. A total of 3842 subjects without clinical cardiovascular disease were included with a mean age of 61 years, 48% male, 39% non‐Hispanic white, 25% Chinese‐American, 23% Hispanic, and 13% black. RV measures were within normal range for age and sex. A 1‐mL/mm Hg decrease in
TAC
was associated with 3.9‐mL smaller
RVESV
, 7.6‐mL smaller
RVEDV
, and 2.4‐g lower
RV
mass. A 5‐Wood‐unit increase in
SVR
was associated with 0.6‐mL decrease in
RVESV
, 1.7‐mL decrease in
RVEDV
, and 0.4‐g decrease in
RV
mass. A 1% increase in
AI
was associated with 0.2‐mL decrease in
RVEDV
. We found significant effect modification by age, sex, and race for some of these relationships, with males, whites, and younger individuals having greater decreases in
RV
volumes and mass.

Conclusions

Markers of increased systemic arterial load were associated with smaller
RV
volumes and lower
RV
mass in a population of adults without clinical cardiovascular disease.
Contemporary Trends and Age‐Specific Sex Differences in Management and Outcome for Patients With ST‐Segment Elevation Myocardial Infarction
Authors: De Luca Leonardo , Marini Marco , Gonzini Lucio , Boccanelli Alessandro , Casella Gianni , Chiarella Francesco , De Servi Stefano , Di Chiara Antonio , Di Pasquale Giuseppe , Olivari Zoran , Caretta Giorgio , Lenatti Laura , Gulizia Michele Massimo , Savonitto Stefano 
Published: November 2016

Background

Age‐ and sex‐specific differences exist in the treatment and outcome of
ST
‐elevation myocardial infarction (
STEMI
). We sought to describe age‐ and sex‐matched contemporary trends of in‐hospital management and outcome of patients with
STEMI
.

Methods and Results

We analyzed data from 5 Italian nationwide prospective registries, conducted between 2001 and 2014, including consecutive patients with
STEMI
. All the analyses were age‐ and sex‐matched, considering 4 age classes: <55, 55 to 64, 65 to 74, and ≥75 years. A total of 13 235 patients were classified as having
STEMI
(72.1% men and 27.9% women). A progressive shift from thrombolysis to primary percutaneous coronary intervention occurred over time, with a concomitant increase in overall reperfusion rates (
P
for trend <0.0001), which was consistent across sex and age classes. The crude rates of in‐hospital death were 3.2% in men and 8.4% in women (
P
<0.0001), with a significant increase over age classes for both sexes and a significant decrease over time for both sexes (all
P
for trend <0.01). On multivariable analysis, age (odds ratio 1.09, 95%
CI
1.07–1.10,
P
<0.0001) and female sex (odds ratio 1.44, 95%
CI
1.07–1.93,
P
=0.009) were found to be significantly associated with in‐hospital mortality after adjustment for other risk factors, but no significant interaction between these 2 variables was observed (
P
for interaction=0.61).

Conclusions

Despite a nationwide shift from thrombolytic therapy to primary percutaneous coronary intervention for
STEMI
affecting both sexes and all ages, women continue to experience higher in‐hospital mortality than men, irrespective of age.
Association of Cholesterol Efflux Capacity With Clinical Features of Metabolic Syndrome: Relevance to Atherosclerosis
Authors: Gall Julie , Frisdal Eric , Bittar Randa , Le Goff Wilfried , Bruckert Eric , Lesnik Philippe , Guerin Maryse , Giral Philippe 
Published: November 2016

Background
The contribution of high‐density lipoprotein to cardiovascular benefit is closely linked to its role in the cellular cholesterol efflux process; however, various clinical and biochemical variables are known to modulate the overall cholesterol efflux process. The aim of this study was to evaluate the extent to which clinical and biological anomalies associated with the establishment of the metabolic syndrome modulate cholesterol efflux capacity and contribute to development of atherosclerosis.

Methods and Results

This study involved patients (n=1202) displaying atherogenic dyslipidemia in primary prevention who were referred to our prevention center. Among these patients, 25% presented at least 3 criteria of the metabolic syndrome, as defined by the National Cholesterol Education Program Adult Treatment Panel III. We measured the capacity of 40‐fold diluted serum to mediate cholesterol efflux from cholesterol‐loaded human
THP
‐1 macrophages. Cholesterol efflux capacity was reduced progressively by 4% to 11% (
P
<0.0001) as a function of the increasing number of coexisting criteria for the metabolic syndrome from 1 to 5. This observation was primarily related to reductions in scavenger receptor class B member 1 and ATP binding cassette subfamily G member 1–dependent efflux. Multivariate analyses indicate that serum efflux capacity was significantly associated with established metabolic syndrome (odds ratio 0.45; 95%
CI
0.28–0.72;
P
=0.009) independent of age, low‐density lipoprotein cholesterol, status with regard to lipid‐lowering therapy, smoking status, and alcohol consumption.

Conclusions
Our study revealed that individual criteria of metabolic syndrome are closely related synergistically to cholesterol efflux capacity. In addition, established metabolic syndrome and cholesterol efflux capacity were independently associated with clinical features of atherosclerosis.
Reconsidering the “Asphalt Identikit”
Authors: Plastow Nicola Ann 
Published: November 2016

Background/Aim The “asphalt identikit” theory suggests that driving cessation inevitably leads to feelings of incompetence and dependency. This article challenges this proposition by investigating the driving-related possible selves of British older adults living in West London. Methods Thematic analysis of data from 19 of 39 interviews in which older adults participating in a larger study talked about driving in the context of their grocery shopping. Results Three themes were evident: “I can drive – that makes a huge difference,” “Expecting to lose my license,” and “I gave up my license.” Discussion Driving cessation is not a dreaded possible self for all older adults. Older adults may use a variety of identity maintenance processes to retain their positive sense of self. Conclusions Mental well-being can be maintained during driving cessation by finding ways to compensate for the loss of a license and finding alternative ways of achieving hoped-for possible selves.
Clinical and Radiological Outcomes After Hamstring Anterior Cruciate Ligament Reconstructions: Comparison Between Fixed-Loop and Adjustable-Loop Cortical Suspension Devices
Authors: Choi Nam-Hong , Yang Bong-Seok , Victoroff Brian N. 
Published: November 2016

Background: Few studies have compared clinical and radiological outcomes after hamstring anterior cruciate ligament (ACL) reconstruction with fixed-loop and adjustable-loop cortical suspension devices. Purpose/Hypothesis: The purpose of this retrospective study was to compare clinical outcomes and tunnel widening after hamstring ACL reconstructions with fixed- and adjustable-loop cortical suspension devices. The hypothesis was that compared with femoral graft fixation with the fixed-loop device, fixation with the adjustable-loop device would show similar clinical outcomes and would result in less tunnel widening after hamstring ACL reconstruction. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 117 consecutive patients underwent hamstring ACL reconstruction at a single institution. The fixed-loop cortical suspension device was used in 67 patients, and the adjustable-loop cortical suspension device was used in 50 patients. All patients were observed for a minimum of 2 years. Postoperative knee laxity was evaluated with the Lachman test, pivot-shift test, and KT-1000 arthrometer. Functional evaluations were performed by use of the Lysholm score and the Tegner activity scale. On anteroposterior (AP) and lateral radiographs, the measured diameters of the femoral tunnel at 1 year after surgery were compared with the diameter of the reamer used at surgery. The measured diameters of the tibial tunnel at 1 year after surgery were compared with those taken immediately after surgery. Results: The mean KT-1000 arthrometer laxity measurement was 1.5 ± 1.8 mm in the fixed-loop group and 1.2 ± 2.3 mm in the adjustable-loop group ( P = .530). Results of postoperative knee laxity evaluations and functional outcomes from both groups showed no statistically significant differences. However, the fixed-loop group showed significantly better stability in the pivot-shift test than did the adjustable-loop group ( P = .018). On AP radiographs, the mean diameter of the femoral and tibial tunnels increased by 42.2% ± 15.9% and 37.0% ± 17.8%, respectively, in the fixed-loop group and by 43.0% ± 15.4% and 36.8% ± 18.2% in the adjustable-loop group. On lateral radiographs, the mean diameter of the femoral and tibial tunnels increased by 38.1% ± 14.8% and 39.9% ± 13.8%, respectively, in the fixed-loop group and by 35.8% ± 12.2% and 38.1% ± 21.0% in the adjustable-loop group. No significant differences were found between the 2 groups in postoperative femoral and tibial tunnel widening on AP radiographs ( P = .801 and .951, respectively) or lateral radiographs ( P = .422 and .621, respectively). Conclusion: Compared with femoral fixation by use of the fixed-loop device, femoral fixation by use of the adjustable-loop device showed similar clinical outcomes but did not reduce tunnel widening after hamstring ACL reconstructions.