bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional significance of transgelin‐2 in uterine cervical squamous cell carcinoma
Authors: Yakabe Kazuyuki , Murakami Akihiro , Kajimura Takuya , Nishimoto Yuki , Sueoka Kotaro , Sato Shun , Nawata Shugo , Sugino Norihiro 
Published: February 2016

AbstractAimTransgelin‐2 (TAGLN2) has previously been found to be highly expressed in uterine cervical squamous cell carcinoma (SCC) tissues by proteomic analyses. The present study investigated the role of TAGLN2 in the malignant behaviors of cervical SCC cells in vitro and in vivo, and the clinical significance of TAGLN2 using immunohistochemistry for human cervical SCC tissues.MethodsAntisense (AS) constructs of TAGLN2 cDNA (AS clones) and the empty vector (control clone) were transfected into a human uterine SCC cell line (SKG IIIa), and malignant behaviors were analyzed in vitro. In an in vivo experiment, 107 cells of the AS and control clones were subcutaneously inoculated into female BALB/c nude mice. In immunohistochemistry with anti‐TAGLN2 antibodies for human cervical SCC, FIGO stage IA and IB (n = 75), the expression patterns of TAGLN2 were divided into two groups: weak and strong. The relation between expression pattern and prognosis was analyzed.ResultsSuppression of TAGLN2 inhibited cancer cell migration and secretion of matrix metalloproteinases. Tumors in the control clone group continued to grow, whereas those in the AS clone group clearly stopped growing. Six weeks after injection, the tumor size was significantly smaller in the AS clone group than in the control clone group. Immunohistochemistry revealed that the strong pattern was associated with poor overall survival compared with the weak pattern by the Kaplan–Meier method.ConclusionTAGLN2 plays functional roles in the progression of cervical SCC. Suppression of TAGLN2 may be a new strategy for the treatment of cervical SCC.
Correlation between transvaginal ultrasound measured endometrial thickness and histopathological findings in Turkish women with abnormal uterine bleeding
Authors: Ozer Alev , Ozer Serdar , Kanat‐Pektas Mine 
Published: February 2016

AbstractAimThe present study aims to determine how transvaginal ultrasonography and histopathological examination findings are correlated in a cohort of premenopausal and postmenopausal Turkish women with abnormal uterine bleeding.MethodsThis is a retrospective review of 350 Turkish women who underwent transvaginal ultrasonography and suction curettage as a result of abnormal uterine bleeding.ResultsSonographic appearance of the endometrium was normal in 244 patients (69.7%), while homogeneous thickening was detected in 47 patients (13.4%) and cystic thickening in 21 patients (6.0%). A sonographic diagnosis of endometrial polyp was made in 38 patients (10.9%). Histopathological analysis of endometrial samplings revealed proliferative endometrium (36%), secretory endometrium (24.6%), decidualization (10.9%), endometrial polyp (8.3%), endometritis (6.8%), endometrial hyperplasia (4.6%), irregular shedding (3.7%), atrophic endometrium (3.1%), endometrial cancer (1.1%) and placental retention (0.9%). The sonographic and histopathological findings correlated significantly (χ2 = 122 768, P = 0.001; r = 0.215, P = 0.001). Approximately 51% of the women with homogeneous endometrial thickening had proliferative endometrium. Only 44.7% of the women with ultrasonographically visualized endometrial polyps had histopathologically diagnosed endometrial polyps. Nearly 57% of the women with cystic endometrial thickening had proliferative endometrium.ConclusionIf there is no facility for hysteroscopy or hysteroscopy‐guided endometrial biopsy for women with abnormal uterine bleeding, transvaginal ultrasonography findings can be efficiently used to make a preliminary diagnosis and, thus, notify the pathologists.
Isolated pregnancy‐induced anti‐thrombin deficiency in a woman with twin pregnancy
Authors: Kawabata Kosuke , Morikawa Mamoru , Yamada Takahiro , Minakami Hisanori 
Published: February 2016

AbstractA woman with twin pregnancy had a gradual decline in anti‐thrombin (AT) activity from 72% at gestational week (GW) 29–3/7, to 53% at GW31–2/7, and to 41% at GW32–2/7, at which time hypertension (148/90 mmHg) and proteinuria (protein‐to‐creatinine ratio [P/Cr], 0.79 mg/mg) developed in the presence of normal platelet count (159 × 109/L) and serum aspartate aminotransferase/lactate dehydrogenase (22/164 IU/L). AT product was given three times to maintain AT activity >50% and blood pressure was maintained below 155/95 mmHg with no treatment, but generalized edema with a weekly weight gain of 4.9 kg and increased proteinuria (to P/Cr, 7.6 mg/mg) required cesarean section at GW33–3/7. This case highlights the occurrence of pregnancy‐induced AT deficiency alone in the absence of any other abnormality, including hypertension, proteinuria, or thrombocytopenia. Measurement of AT activity was considered helpful for determination of the appropriate time for delivery in this patient.
Why Firms Delay Reaching True Sustainability
Authors: Shevchenko Anton , Lévesque Moren , Pagell Mark 
Published: February 2016

AbstractThis paper explores a discrepancy between what the literature says about sustainability and how sustainability is actually practiced. Our analysis reveals that we are in a transition era in which firms incrementally offset – rather than eliminate – their negative impacts on the environment and society. We also argue that external stakeholders have yet to create the conditions that would compel firms to become truly sustainable. We further find that a firm's response to external pressure to become truly sustainable greatly depends on its capabilities. For large firms, the decision to become truly sustainable is driven by their ability to manage external stakeholders’ expectations, with the most innovative of large firms remaining unsustainable even in the long term. In contrast, small innovative firms guide their decision‐making based on their internal readiness to change and therefore will be the first to reach true sustainability. Finally, and regardless of size, firms that lack an innovation capability are unlikely to become truly sustainable; they will struggle to survive the transition era.
No Ethics Without Things
Authors: George Kenneth M. 
Published: February 2016

AbstractJust as recognition and pursuit of the human good take place in language and action, so too do they unfold in encounter with the material and visual. The ethical crises, projects, and striving we see in everyday religious life are worked out not just in the intersubjective play and politics of language but also in encounter with, in dwelling with, material and visual substances and forms. This essay considers the material conditions that make possible the “ethical pleasures” sought by Indonesian painter A. D. Pirous in making and displaying contemporary works of “Islamic art,” most especially works that make “visual recitation” of passages from the Qur'an.
A Response to “Participation: A Religious Worldview” by James M. Gustafson
Authors: Schweiker William 
Published: February 2016

AbstractThis response offers an interpretation of James Gustafson's “Participation: A Religious Worldview,” which thinks with Gustafson on the theme of “participation,” while highlighting points where my own thoughts diverge from his. The essay begins by drawing the reader's attention to Gustafson's style, arguing that the simple elegance of his writing constitutes part of his larger claim about the need to remove ourselves from the center of our thought. Next, the essay analyzes Gustafson's use of “participation” by putting it in context and connecting it with his broader methodology. Finally, I draw the reader's attention to important loci in the text in order to show how Gustafson's essay helps address various extant misinterpretations of his thought but also to point to ways in which my “thinking with” Gustafson leads me to think otherwise than he does.
Rethinking Moral Agency in Markets: A Book Discussion on Behavioral Economics
Authors: McRorie Christina 
Published: February 2016

AbstractRecent work in behavioral economics and psychology provides valuable resources for religious ethicists. This book discussion examines contributions by Cass Sunstein, Daniel Kahneman, George Akerlof and Rachel Kranton, Uri Gneezy and John A. List, and Douglas Hough. This literature raises important questions about ethical decision‐making, moral agency and responsibility, and the ethics of life in global capitalism. It also opens up promising areas for interdisciplinary dialogue between economics and religious studies. This book discussion concludes that religious ethicists have much to contribute to the conversations about moral anthropology that are now being held in behavioral economic research, and to the broader political economic debates in which this research participates.
Ontogenic variation and effect of collection procedure on leaf biomechanical properties of Mediterranean seagrass Posidonia oceanica (L.) Delile
Authors: de los Santos Carmen B. , Vicencio‐Rammsy Bárbara , Lepoint Gilles , Remy François , Bouma Tjeerd J. , Gobert Sylvie 
Published: February 2016

AbstractLeaf mechanical traits are important to understand how aquatic plants fracture and deform when subjected to abiotic (currents or waves) or biotic (herbivory attack) mechanical forces. The likely occurrence of variation during leaf ontogeny in these traits may thus have implications for hydrodynamic performance and vulnerability to herbivory damage, and may be associated with changes in morphologic and chemical traits. Seagrasses, marine flowering plants, consist of shoot bundles holding several leaves with different developmental stages, in which outer older leaves protect inner younger leaves. In this study we examined the long‐lived seagrass Posidonia oceanica to determine ontogenic variation in mechanical traits across leaf position within a shoot, representing different developmental stages. Moreover, we investigated whether or not the collection procedure (classical uprooted shoot versus non‐destructive shoot method: cutting the shoot without a portion of rhizome) and time span after collection influence mechanical measurements. Neither collection procedure nor time elapsed within 48 h of collection affected measurements of leaf biomechanical traits when seagrass shoots were kept moist in dark cool conditions. Ontogenic variation in mechanical traits in P. oceanica leaves over intermediate and adult developmental stages was observed: leaves weakened and lost stiffness with aging, while mid‐aged leaves (the longest and thickest ones) were able to withstand higher breaking forces. In addition, younger leaves had higher nitrogen content and lower fiber content than older leaves. The observed patterns may explain fine‐scale within‐shoot ecological processes of leaves at different developmental stages, such as leaf shedding and herbivory consumption in P. oceanica.
Characterization of Mason Gully (H5): The second recovered fall from the Desert Fireball Network
Authors: Dyl Kathryn A. , Benedix Gretchen K. , Bland Phil A. , Friedrich Jon M. , Spurný Pavel , Towner Martin C. , O'Keefe Mary Claire , Howard Kieren , Greenwood Richard , Macke Robert J. , Britt Daniel T. , Halfpenny Angela , Thostenson James O. , Rudolph Rebecca A. , Rivers Mark L. , Bevan Alex W. R. 
Published: February 2016

AbstractMason Gully, the second meteorite recovered using the Desert Fireball Network (DFN), is characterized using petrography, mineralogy, oxygen isotopes, bulk chemistry, and physical properties. Geochemical data are consistent with its classification as an H5 ordinary chondrite. Several properties distinguish it from most other H chondrites. Its 10.7% porosity is predominantly macroscopic, present as intergranular void spaces rather than microscopic cracks. Modal mineralogy (determined via PS‐XRD, element mapping via energy dispersive spectroscopy [EDS], and X‐ray tomography [for sulfide, metal, and porosity volume fractions]) consistently gives an unusually low olivine/orthopyroxene ratio (0.67−0.76 for Mason Gully versus ~1.3 for typical H5 ordinary chondrites). Widespread “silicate darkening” is observed. In addition, it contains a bright green crystalline object at the surface of the recovered stone (diameter ≈ 1.5 mm), which has a tridymite core with minor α‐quartz and a rim of both low‐ and high‐Ca pyroxene. The mineralogy allows the calculation of the temperatures and ƒ(O2) characterizing thermal metamorphism on the parent body using both the two‐pyroxene and the olivine‐chromite geo‐oxybarometers. These indicate that MG experienced a peak metamorphic temperature of ~900 °C and had a similar ƒ(O2) to Kernouvé (H6) that was buffered by the reaction between olivine, metal, and pyroxene. There is no evidence for shock, consistent with the observed porosity structure. Thus, while Mason Gully has some unique properties, its geochemistry indicates a similar thermal evolution to other H chondrites. The presence of tridymite, while rare, is seen in other OCs and likely exogenous; however, the green object itself may result from metamorphism.
Rb‐Sr and Sm‐Nd isotopic and REE studies of igneous components in the bulk matrix domain of Martian breccia Northwest Africa 7034
Authors: Nyquist Laurence E. , Shih Chi‐Yu , McCubbin Francis M. , Santos Alison R. , Shearer Charles K. , Peng Zhan X. , Burger Paul V. , Agee Carl B. 
Published: February 2016

AbstractThe bulk matrix domain of the Martian breccia NWA 7034 was examined petrographically and isotopically to better understand the provenance and age of the source material that make up the breccia. Both 147Sm‐143Nd and 146Sm‐142Nd age results for mineral separates from the bulk matrix portion of breccia NWA 7034 suggest that various lithological components in the breccia probably formed contemporaneously ~4.44 Ga ago. This old age is in excellent agreement with the upper intersection ages (4.35–4.45 Ga) for U‐Pb discordia and also concordia defined by zircon and baddeleyite grains in matrix and igneous‐textured clasts. Consequently, we confirm an ancient age for the igneous components that make up the NWA 7034 breccia. Substantial disturbance in the Rb‐Sr system was detected, and no age significance could be gleaned from our Rb‐Sr data. The disturbance to the Rb‐Sr system may be due to a thermal event recorded by bulk‐rock K‐Ar ages of 1.56 Ga and U‐Pb ages of phosphates at about 1.35–1.5 Ga, which suggest partial resetting from an unknown thermal event(s), possibly accompanying breccia formation. The NWA 7034 bulk rock is LREE enriched and similar to KREEP‐rich lunar rocks, which indicates that the earliest Martian crust was geochemically enriched. This enrichment supports the idea that the crust is one of the enriched geochemical reservoirs on Mars that have been detected in studies of other Martian meteorites.
Ethnic belonging of the children born out of rape in postconflict Bosnia‐Herzegovina and Rwanda
Authors: Hamel Marie‐Eve 
Published: February 2016

AbstractSexual violence has been used as a weapon of war in ethnic conflicts, and forced impregnations have been central to this strategy. Scholars however disagree on whether the cultural assimilation to the maternal group influences these children's identities, or whether they are perceived as belonging to the enemy group (Carpenter; Nikolic‐Ristanovic). Drawing on preliminary qualitative findings collected in 2013 in Rwanda and Bosnia‐Herzegovina, this paper analyses the ethnic identification imposed by the enemy group, the mothers and their community on the children born out of rape. It first explores how the mothers' ethnic identities are often subordinated to their fathers' ethnic background, and how this then justifies their social exclusion from their maternal ethnic group. This paper suggests that sexual violence is extremely effective in ensuring the continuation of the ethnic conflict in the aftermath of the violence by attacking the children's senses of belonging.
Recurrent ischemic stroke and palmoplantar pustulosis caused by occult postoperative infective endocarditis
Authors: Gon Yasufumi , Sakaguchi Manabu , Mochizuki Hideki 
Published: February 2016

AbstractStroke is occasionally the first manifestation of occult infective endocarditids. Although infective endocarditids commonly presents acutely, infective endocarditids remains a diagnostic challenge in a patient with few symptoms or culture‐negative endocarditis. Here, we present a 74‐year‐old Japanese woman with recurrent ischemic stroke and palmoplantar pustulosis caused by occult postoperative infective endocarditids. She had undergone an operation for mitral regurgitation, mitral annuloplasty, 4 years before admission. Intriguingly, our patient suffered from intractable palmoplantar pustulosis after cardiac surgery, but the patient's cutaneous manifestations completely resolved after treatment of occult postoperative infective endocarditids. In patients with unexplained intermittent fever and palmoplantar pustulosis after cardiac surgery, clinicians need to consider the possibility of occult postoperative infective endocarditids.
Endoplasmic reticulum stress participates in inflammation‐accelerated, lipid‐mediated injury of human glomerular mesangial cells
Authors: Yang Haiping , Cui Jingjing , Shi Jing , Yang Baohui , Wang Mo , Wu Daoqi , Zhang Gaofu , Liu Wei , Li Qiu 
Published: February 2016

AbstractAimThe mechanism of lipid‐mediated injury of human glomerular mesangial cells (HMCs) remains unclear. We investigated the association between endoplasmic reticulum (ER) stress and lipid‐mediated injury in HMCs in vitro and the potential efficacy of a therapeutic approach targeting ER stress.MethodsHuman glomerular mesangial cells were exposed to low‐density lipoprotein (LDL) and/or interleukin‐1β (IL‐1β). For evaluation of whether ER stress participates in lipid‐mediated injury to HMCs, HMCs were pretreated with tunicamycin or treated with sodium 4‐phenylbutyrate (4‐PBA).ResultsIncubation of HMCs with LDL + IL‐1β significantly increased lipid accumulation and induced phenotypic changes. ER stress was induced in lipid‐loaded HMCs, as indicated by upregulation of glucose‐regulated protein 78 (GRP78) and protein kinase RNA‐like ER kinase (PERK) proteins. Moreover, persistent ER stress increased expression of nuclear factor (NF)‐κB p65 protein, fibronectin, and α‐smooth muscle actin (α‐SMA) mRNA partly through the PERK − eukaryotic initiation factor‐2α (eIF2α) pathway. Preconditioning with ER stress by tunicamycin and inhibition of ER stress by 4‐PBA both reversed the phenotypic changes and decreased lipid accumulation and inflammatory cytokine secretion by the PERK − eIF2α pathway.ConclusionThese data provide evidence that ER stress participates in inflammation associated with lipid‐induced injury of HMCs. Modulation of ER stress may be a novel therapeutic approach for combating lipid‐induced injury of HMCs.
Muscle strength, mobility, quality of life and falls in patients on maintenance haemodialysis: A prospective study
Authors: Wang Amanda Y , Sherrington Catherine , Toyama Tadashi , Gallagher Martin P , Cass Alan , Hirakawa Yochiro , Li Qiang , Sukkar Louisa , Snelling Paul , Jardine Meg J 
Published: February 2016

AbstractAimThe aim is to explore (i) the relationship between quality of life and physical parameters (muscle strength and mobility) among people undergoing maintenance haemodialysis; (ii) changes in strength and mobility over time and predictors of changes; and (iii) whether strength and mobility were associated with falls.MethodsWe recruited 51 maintenance haemodialysis patients to a prospective longitudinal study. Baseline quality of life was assessed using the SF‐36 physical component summary and mental component summary scores. Muscle strength (ankle dorsiflexion strength measured with a hand‐held dynamometer), mobility (short physical performance battery) and falls history were assessed at baseline, 12 and 36 months. Associations between variables at baseline were assessed with linear regression models. Changes in physical parameters were evaluated with paired t‐tests and prediction of falls assessed by negative binominal regression.ResultsFifty and 34 patients completed 12 and 36 month follow‐ups, respectively. Baseline mobility but not muscle strength correlated with physical component summary (P = 0.01 and P = 0.23, respectively). Neither baseline mobility nor muscle strength correlated with mental component summary. At 12 months, muscle strength and mobility had significantly deteriorated (mean ankle dorsiflexion strength 11.0 lb (SD 1.5) from 14.0 lb (SD 2.2), P < 0.01; short physical performance battery 8.5 (SD 2.8) from 9.3 (SD 2.6), P < 0.01). Falls at 12 and 36 months were predicted by baseline mobility (P = 0.06 and P = 0.02, respectively) but not muscle strength.ConclusionPhysical parameters appear to be associated with meaningful patient outcomes and showed measurable deterioration over relatively short time frames. Interventions, with the potential to slow physical decline in people receiving maintenance dialysis, such as exercise programmes, warrant further investigation.
Community‐acquired acute kidney injury: A challenge and opportunity for primary care in kidney health
Authors: Mesropian Paul Der , Othersen Jennifer , Mason Darius , Wang Jeffrey , Asif Arif , Mathew Roy O 
Published: February 2016

AbstractCommunity‐acquired acute kidney injury (CA‐AKI) has been found to be a common event in the population. Current incidence estimates are not available, but evaluations of severe elevations in serum creatinine indicate that incidence can be as high as 989 cases per million population in those older than 80 years. Data on risk factors are limited, but older age and higher comorbid illness burden, especially diabetes and cardiovascular disease, seem to be more common in patients who suffer CA‐AKI. In addition to being more common than hospital‐acquired AKI, the long‐term sequelae of CA‐AKI seem to be just as severe, including renal disease progression and mortality. Efforts to better understand the aetiology of CA‐AKI and how ultimately to prevent the development of this condition will need to be taken. In the meantime, a concerted effort by general internists and nephrologists will be needed to prevent CA‐AKI in the highest risk patients and thus limit the poor outcomes associated with this entity.