bluuebunny/crossref_metadata_2025_split huggingface dataset:
Site‐level factors affecting nursing home implementation of a personalized music intervention: Qualitative analyses from Music & Memory: A Pragmatic Trial for Nursing Home Residents with Alzheimer's Disease (METRIcAL)
Authors: Natalie Davoodi , Miranda Olson , Rebecca Uth , Rosa Baier , James Rudolph , Esme Zediker , Renee Shield , McCreedy Ellen 
Published: October 2024

AbstractBACKGROUNDNon‐pharmacological interventions (NPIs) are preferred alternatives to using antipsychotic medications to manage disruptive behaviors in nursing home (NH) residents living with dementia. However, the implementation of these interventions is often complex in the NH environment. In this qualitative analysis of data from an embedded pragmatic clinical trial (ePCT) of a personalized music intervention, we describe NH‐level implementation barriers and facilitators.METHODSIn a 54‐facility trial, we randomized 27 NHs from four US corporations to the personalized music intervention. In this qualitative analysis, we analyzed barriers and facilitators at 9 of the 27 intervention NHs, using (1) routinely collected data collector observations and (2) semi‐structured interviews with NH staff. We iteratively developed codes to best describe these data and generated themes.RESULTSWe found five qualitative themes related to the variation of intervention implementation across NHs: (1) turnover and institutional changes interfered with implementation; (2) consistent with pragmatic implementation, delivery strategies varied across NHs; (3) family members influenced residents’ participation; (4) non‐clinical program champions needed clinical buy‐in, which was challenging and required demonstrating the intervention's clinical benefits; and (5) technological barriers among staff and residents impeded implementation.CONCLUSIONSQualitative results from nine facilities participating in a NH ePCT of personalized music intervention highlight the importance of identifying an intervention's key components to ensure fidelity, while allowing the flexibility necessary for pragmatic implementation. Engaging family caregivers may improve the implementation of NPIs in the NH setting. Results may be helpful to other researchers implementing NPIs to manage neuropsychiatric symptoms for people living with dementia in NHs.Highlights
This was a real‐world trial of a personalized music for nursing home (NH) residents with dementia.
Pragmatic adaptations to intervention delivery may have compromised fidelity.
Family caregivers are important to the success of behavioral interventions in NHs.
Winning of inhomogeneous bad for curves
Authors: Datta Shreyasi , Shao Liyang 
Published: October 2024

Abstract
We prove the absolute winning property of weighted inhomogeneous badly approximable vectors on nondegenerate analytic curves. This answers a question by Beresnevich, Nesharim, and Yang. In particular, our result is an inhomogeneous version of the main result in (Duke Math J 171(14), 2022) by Beresnevich, Nesharim, and Yang. Also, the generality of the inhomogeneous part that we considered extends the previous result in An et al. (Adv Math 324:148–202, 2018). Moreover, our results even contribute to classical results, namely establishing the inhomogeneous Schmidt’s conjecture in arbitrary dimensions.
Hopfian wreath products and the stable finiteness conjecture
Authors: Bradford Henry , Fournier-Facio Francesco 
Published: October 2024

AbstractWe study the Hopf property for wreath products of finitely generated groups, focusing on the case of an abelian base group. Our main result establishes a strong connection between this problem and Kaplansky’s stable finiteness conjecture. Namely, the latter holds true if and only if for every finitely generated abelian group A and every finitely generated Hopfian group $$\Gamma $$
Γ
the wreath product $$A \wr \Gamma $$

A
≀
Γ

is Hopfian. In fact, we characterize precisely when $$A \wr \Gamma $$

A
≀
Γ

is Hopfian, in terms of the existence of one-sided units in certain matrix algebras over $${\mathbb {F}}_p[\Gamma ]$$

F
p

[
Γ
]

, for every prime p occurring as the order of some element in A. A tool in our arguments is the fact that fields of positive characteristic locally embed into matrix algebras over $$\mathbb {F}_p$$

F
p

thus reducing the stable finiteness conjecture to the case of $$\mathbb {F}_p$$

F
p

. A further application of this result shows that the validity of Kaplansky’s stable finiteness conjecture is equivalent to a version of Gottschalk’s surjunctivity conjecture for additive cellular automata.
Metric compatibility and determination in complete metric spaces
Authors: Daniilidis Aris , Le Tri Minh , Salas David 
Published: October 2024

AbstractThe local slope operator was introduced in De Giorgi et al. (Atti Accad Naz Lincei Rend Cl Sci Fis Mat Nat 68:180–187, 1980) to study gradient flow dynamics in metric spaces. This tool has now become a cornerstone in metric evolution equations (see, e.g., Ambrosio et al. (Gradient flows in metric spaces and in the space of probability measures, Lectures in Mathematics. Birkhauser, 2008). Very recently, in Daniilidis and Salas (Proc Am Math Soc 150:4325–4333, 2022), it was established that Lipschitz inf-compact functions are uniquely determined by their local slope and critical values. Compactness played a paramount role in this result, ensuring in particular the existence of critical points. We hereby emancipate from this restriction and establish a determination result for merely bounded from below functions, by adding an assumption controlling the asymptotic behavior. This assumption is trivially fulfilled if f is inf-compact. In addition, our result is not only valid for the (De Giorgi) local slope, but also for the main paradigms of average descent operators as well as for the global slope, case in which the asymptotic assumption becomes superfluous. Therefore, the present work extends simultaneously the metric determination results of Daniilidis and Salas (Proc Am Math Soc 150:4325–4333, 2022) and Thibault and Zagrodny (Commun Contemp Math 25(7):2250014, 2023).
Avoidance and attraction responses of kittiwakes to three offshore wind farms in the North Sea
Authors: Pollock Christopher J. , Johnston Daniel T. , Boersch-Supan Philipp H. , Thaxter Chris B. , Humphreys Elizabeth M. , O’Hanlon Nina J. , Clewley Gary D. , Weston Ewan D. , Shamoun-Baranes Judy , Cook Aonghais S. C. P. 
Published: October 2024

AbstractSeabird collision risk is a key concern in relation to the environmental impacts associated with offshore wind farms (OWFs). Understanding how species respond both to the wind farm itself, and individual turbines within the wind farm, is key to enabling better quantification and management of collision risk. Collision risk is of particular concern for the black-legged kittiwake, Rissa tridactyla, where modelling predicts unsustainable population level impacts. In this study 20 adult breeding kittiwakes, were tracked with GPS from Whinnyfold, Scotland (57°23′07″N, 001°52′11″W) during the breeding season in 2021. An Avoidance-Attraction Index (AAI) was estimated at several bands within macro- and meso-scales (0–4 km from outer boundary and 0–400 m from turbines, respectively), and the Avoidance Rate (AR; used in environmental impact assessments) at macro-scale to estimate avoidance behaviour to three operational OWFs within their foraging range. One offshore wind farm and its buffer zone (0–4 km from outer boundary) was visited more frequently by the majority of tracked individuals (19/20 birds), despite being twice as far as the closest OWF (17.3 and 31.9 km respectively), whilst 10 or less individuals used the remaining two OWFs. At the most frequented OWF we found macro-scale attraction to the closest band (0–1 km) trending towards avoidance in the furthest band (3–4 km). At the meso-scale we found avoidance of areas below the rotor height range (RHR, a.k.a. rotor swept area/zone) up to 120 m from individual turbines, which decreased to 60 m when within the RHR. Our results indicate that kittiwakes may be slightly attracted to the area around OWFs or aggregate here due to displacement but avoid individual turbines. Increased productivity in the OWF area may potentially be drawing birds into the general area, with aversion to individual turbines being responsible for meso-scale observations.
Mechanical properties of pediatric low-grade gliomas in children with and without neurofibromatosis type 1
Authors: McIlvain Grace , Hayes Laura L. , Walter Andrew W. , Averill Lauren W. , Kandula Vinay , Johnson Curtis L. , Nikam Rahul M. 
Published: October 2024

Abstract
Introduction
Prognoses for pediatric brain tumors are suboptimal, as even in low-grade tumors, management techniques can lead to damage in the developing brain. Therefore, advanced neuroimaging methods are critical for developing optimal management plans and improving patient care. Magnetic resonance elastography (MRE) has allowed for the characterization of adult gliomas by their mechanical properties, which are uniquely sensitive to the complex interplay of cellularity, vasculature, and interstitium. However, pediatric tumors differ in behavior and cytoarchitecture, and their mechanical properties have never been assessed.

Methods
Here, we conduct the first study of pediatric brain tumor mechanical properties by using MRE to measure tissue stiffness and damping ratio in low grade gliomas (LGGs). We additionally measure the mechanical properties of non-neoplastic focal abnormal signal intensities (FASIs) in children with neurofibromatosis type 1 (NF1).

Results
23 patients age 4–17 years who had MR imaging results consistent with a primary LGG or with NF1 were included in this study. We found that pediatric gliomas are on an average 10.9% softer (p = 0.010) with a 17.3% lower (p = 0.009) viscosity than reference tissue. Softness of tumors appeared consistent across tumor subtypes and unrelated to tumor size or contrast-enhancement. In NF1 we found that, unlike gliomas, FASIs are stiffer, though not significantly, than reference tissue by an average of 10.4% and have a 16.7% lower damping ratio.

Conclusions
Measuring tumor mechanical properties patterning and heterogeneity has potential to aid in prediction of biological behavior and inform management strategies for pediatric patients.
Comparative Outcomes of Superomedial and Inferior Pedicles in Breast Reduction and Mastopexy: A Meta-Analysis of 5123 Breasts
Authors: Tanas Yousef , Tanas Julie 
Published: October 2024

Abstract
Background
Superomedial and inferior pedicles are two commonly used techniques in breast reduction and mastopexy. This systematic review and meta-analysis aims to compare the clinical outcomes associated with these two techniques.

Methods
PubMed, Scopus, and Web of Science were searched for relevant studies. We included all studies with data comparing superomedial and inferior pedicles. Statistical analyses were performed using RevMan version 5.4.

Results
The search yielded 1075 studies, of which 15 were included in the meta-analysis, encompassing 2633 patients (5123 breasts), with 3491 breasts receiving superomedial pedicles and 1632 breasts receiving inferior pedicles. Superomedial pedicles were associated with significantly shorter operative length (MD = − 24.71, 95% CI = − 37.63 to − 11.79, p = 0.0002), higher BREAST-Q breast satisfaction scores (MD = 10.34, 95% CI = 7.72 to 12.96, p < 0.00001), lower infection rates (RR = 0.46, 95% CI = 0.24 to 0.86, p = 0.02), higher incidence of seroma (RR = 3.00, 95% CI = 1.15 to 7.79, p = 0.02), and higher incidence of decreased nipple–areola complex (NAC) sensation (RR = 1.50, 95% CI = 1.12 to 2.01, p = 0.006). No significant differences were observed in asymmetry, fat necrosis, NAC loss, and hematoma.

Conclusion
Superomedial pedicles demonstrated higher incidences of decreased NAC sensation and seroma formation, lower incidence of infection, shorter operative length, and higher BREAST-Q breast satisfaction scores compared to inferior pedicles. Further research is needed to confirm these findings and explore the long-term aesthetic outcomes associated with both techniques.

Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Bacterial phylotypes associated with rock-dwelling Umbilicaria Lichens from Arctic/Subarctic areas in North America and Northern Europe
Authors: He Zichen , Naganuma Takeshi , Faluaburu Merry Sailonga , Nakai Ryosuke , Kanda Hiroshi , Uchida Masaki , Imura Satoshi , Hahn Martin W. 
Published: October 2024

AbstractThe diversity of bacteria associated with lichens has received increasing attention. However, studies based on next-generation sequencing of microbiomes have not yet been conducted in the Arctic and Subarctic regions. In this study, rock-dwelling lichens belonging to the Umbilicariaceae family were sampled from the Arctic and Subarctic biological zones. The primary research purpose was to undertake a comparative investigation of the bacterial composition and diversity, identify potential indicators, and explore their potential metabolic pathways. 18S rRNA gene sequences of the fungal partner belonging to the genus Umbilicaria (Ascomycota) and the algal partner affiliated with the lineage Trebouxia (Chlorophyta). Comparing Umbilicaria spp. with a previous study in the Antarctic zone, the fungal partners were more inclined to cluster by sampling region. Operational taxonomic units (OTUs) were established based on a predetermined similarity threshold for V3-V4 sequences, which were ascribed to 19 bacterial phyla, and ten of them were consistently present in all samples. The most distinct zonal indicator genera based on OTU frequencies from Arctic and Subarctic lichens were Capsulimonas (Armatimonadota) and Jatrophihabitans (Actinomycota), respectively. Although the Subarctic zone had higher biodiversity and species richness based on alpha-diversity, the beta-diversity showed that the main species of bacterial communities were not significantly different, and the predictions of metabolic pathways based on the bacterial microbiome in lichen samples from the two zones were similar. These findings provide evidence that the geographical and/or bioclimatic environment and the different lichen-forming fungal species mainly and partially influence bacterial microbiomes and metabolic pathways.
The mitochondrial genomes of the reef-dwelling spiny lobsters Panulirus echinatus and Panulirus interruptus with insights into the phylogeny and adaptive evolution of protein-coding genes in the Achelata
Authors: Baker Alyssa M. , Stephens Natalie C. , Diniz Fabio Mendonca , León F. J. García-de , Baeza J. Antonio 
Published: October 2024

AbstractTemperature and oxygen levels drive the evolution of morphological, behavioral, and physiological traits in marine invertebrates, including crustaceans. Environmental conditions are also expected to prompt the adaptive evolution of mitochondrial protein-coding genes (PCGs), which are vital for energy production via the oxidative phosphorylation pathway. We formally tested for adaptive evolution in mitochondrial protein-coding genes in representatives of the decapod infraorder Achelata, including two spiny lobsters, Panulirus echinatus and P. interruptus, for which we sequenced complete mitochondrial genomes (15,644 and 15,659 bp long, respectively). A phylomitogenomic analysis supported the monophyly of the genus Panulirus, the families Palinuridae and Scyllaridae, and the infraorder Achelata. Over the strong negative selection background observed for mitochondrial PCGs in the Achelata, signatures of positive selective pressure were detected within PCGs in equatorial Panulirus spp. and deepwater Scyllaridae. In Panulirus spp. inhabiting equatorial latitudes with consistently high temperatures, the Datamonkey analysis RELAX suggested intensified purifying selection strength in 9 of the 13 PCGs and relaxation in purifying selection strength in atp6, while aBSREL, BUSTED, and MEME recovered signatures of positive selection on PCGs within Complex I, III, and IV PCGs. Likewise, in Scyllaridae species inhabiting depths with low-oxygen levels, RELAX indicated relaxed selection strength in 6 of the 13 PCGs, while aBSREL, BUSTED, and MEME recovered signatures of positive selection on PCGs within Complexes I, III, IV, and V. The newly assembled mitochondrial genomes of P. echinatus and P. interruptus represent new genomic resources to aid with the conservation and management of lobsters targeted by major fisheries and contribute to our understanding of how environmental conditions drive adaptive evolution in spiny and slipper lobster mitochondrial PCGs.
Olfactory and gustatory chemical sensor systems in the African turquoise killifish: Insights from morphology
Authors: Giaquinto Daniela , Fonsatti Elisa , Bortoletti Martina , Radaelli Giuseppe , De Felice Elena , de Girolamo Paolo , Bertotto Daniela , D’Angelo Livia 
Published: October 2024

AbstractSmell and taste are extensively studied in fish species as essential for finding food and selecting mates while avoiding toxic substances and predators. Depending on the evolutionary position and adaptation, a discrete variation in the morphology of these sense organs has been reported in numerous teleost species. Here, for the first time, we approach the phenotypic characterization of the olfactory epithelium and taste buds in the African turquoise killifish (Nothobranchius furzeri), a model organism known for its short lifespan and use in ageing research. Our observations indicate that the olfactory epithelium of N. furzeri is organized as a simple patch, lacking the complex folding into a rosette, with an average size of approximately 600 µm in length, 300 µm in width, and 70 µm in thickness. Three main cytotypes, including olfactory receptor neurons (CalbindinD28K), supporting cells (β-tubulin IV), and basal cells (Ki67), were identified across the epithelium. Further, we determined the taste buds’ distribution and quantification between anterior (skin, lips, oral cavity) and posterior (gills, pharynx, oesophagus) systems. We identified the key cytotypes by using immunohistochemical markers, i.e. CalbindinD28K, doublecortin, and neuropeptide Y (NPY) for gustatory receptor cells, glial fibrillary acidic protein (GFAP) for supporting cells, and Ki67, a marker of cellular proliferation for basal cells. Altogether, these results indicate that N. furzeri is a microsmatic species with unique taste and olfactory features and possesses a well-developed posterior taste system compared to the anterior. This study provides fundamental insights into the chemosensory biology of N. furzeri, facilitating future investigations into nutrient-sensing mechanisms and their roles in development, survival, and ageing.
Preoperative nTMS analysis: a sensitive tool to detect imminent motor deficits in brain tumor patients
Authors: Moritz Ina , Engelhardt Melina , Rosenstock Tizian , Grittner Ulrike , Schweizerhof Oliver , Khakhar Rutvik , Schneider Heike , Mirbagheri Andia , Zdunczyk Anna , Faust Katharina , Vajkoczy Peter , Picht Thomas 
Published: October 2024

Abstract

Background
One of the challenges in surgery of tumors in motor eloquent areas is the individual risk assessment for postoperative motor disorder. Previously a regression model was developed that permits estimation of the risk prior to surgery based on topographical and neurophysiological data derived from investigation with nTMS (navigated Transcranial Magnetic Stimulation). This study aims to analyze the impact of including additional neurophysiological TMS parameters into the established risk stratification model for motor outcome after brain tumor surgery.

Methods
Biometric and clinical data of 170 patients with glioma in motor eloquent areas were collected prospectively. In addition, the following nTMS parameters were collected bihemispherically prior to surgery: resting motor threshold (RMT), recruitment curve (RC), cortical silent period (CSP) and a nTMS based fibertracking to measure the tumor tract distance (TTD). Motor function was quantified by Medical Research Council Scale (MRCS) preoperatively, seven days and three months postoperatively. Association between nTMS parameters and postoperative motor outcome was investigated in bivariate and multivariable analyses.

Results
The bivariate analysis confirmed the association of RMT ratio with the postoperative motor outcome after seven days with higher rates of worsening in patients with RMT ratio > 1.1 compared to patients with RMT ratio ≤ 1.1 (31.6% vs. 15.1%, p = 0.009). Similarly, an association between a pathological CSP ratio and a higher risk of new postoperative motor deficits after seven days was observed (35.3% vs. 16.7% worsening, p = 0.025). A pathological RC Ratio was associated postoperative deterioration of motor function after three months (42.9% vs. 16.2% worsening, p = 0.004). In multiple regression analysis, none of these associations were statistically robust.

Conclusions
The current results suggest that the RC ratio, CSP ratio and RMT ratio individually are sensitive markers associated with the motor outcome 7 days and 3 months after tumor resection in a presumed motor eloquent location. They can therefore supply valuable information during preoperative risk–benefit-balancing. However, underlying neurophysiological mechanisms might be too similar to make the parameters meaningful in a combined model.
Tectal glioma: clinical, radiological, and pathological features, and the importance of molecular analysis
Authors: Imoto Ryoji , Otani Yoshihiro , Fujii Kentaro , Ishida Joji , Hirano Shuichiro , Kemmotsu Naoya , Suruga Yasuki , Mizuta Ryo , Kegoya Yasuhito , Inoue Yohei , Umeda Tsuyoshi , Hokama Madoka , Washio Kana , Yanai Hiroyuki , Tanaka Shota , Satomi Kaishi , Ichimura Koichi , Date Isao 
Published: October 2024

AbstractTectal glioma (TG) is a rare lower grade glioma (LrGG) that occurs in the tectum, mainly affecting children. TG shares pathological similarities with pilocytic astrocytoma (PA), but recent genetic analyses have revealed distinct features, such as alterations in KRAS and BRAF. We conducted a retrospective review of cases clinically diagnosed as TG and treated at our institute between January 2005 and March 2023. Six cases were identified and the median age was 30.5 years. Four patients underwent biopsy and two patients underwent tumor resection. Histological diagnoses included three cases of PA, one case of astrocytoma, and two cases of high-grade glioma. The integrated diagnosis, according to the fifth edition of the World Health Organization Classification of Tumours of the central nervous system, included two cases of PA and one case each of diffuse high-grade glioma; diffuse midline glioma H3 K27-altered; glioblastoma; and circumscribed astrocytic glioma. Among the three patients who underwent molecular evaluation, two had KRAS mutation and one had H3-3A K27M mutation. Our results demonstrate the diverse histological and molecular characteristics of TG distinct from other LrGGs. Given the heterogeneous pathological background and the risk of pathological progression in TG, we emphasize the importance of comprehensive diagnosis, including molecular evaluation.