bluuebunny/crossref_metadata_2025_split huggingface dataset:
First image-guided treatment of a mouse tumor with radioactive ion beams
Authors: Durante Marco , Boscolo Daria , Lovatti Giulio , Sokol Olga , Vitacchio Tamara , Evangelista Francesco , Haettner Emma , Tinganelli Walter , Graeff Christian , Weber Uli , Schuy Christoph , Nitta Munetaka , Moglioni Martina , Kostyleva Daria , Purushothaman Sivaji , Thirolf P , Bortfeldt Jonathan , Scheidenberger C. , Parodi Katia 
Published: October 2024

Abstract

Radioactive ion beams (RIB) are a key focus of current research in nuclear physics. Already long ago it was proposed that they could have applications in cancer therapy. In fact, while charged particle therapy is potentially the most effective radiotherapy technique available, it is highly susceptible to uncertainties in the beam range. RIB are well-suited for image-guided particle therapy, as isotopes that undergo β+-decay can be precisely visualized using positron emission tomography (PET), enabling accurate real-time monitoring of the beam range. We successfully treated a mouse osteosarcoma using a radioactive 11C-ion beam. The tumor was located in the neck, in close proximity to the spinal cord, increasing the risk of radiation-induced myelopathy from even slight variations in the beam range caused by anatomical changes or incorrect calibration of the planning CT. We managed to completely control the tumor with the highest dose while minimizing toxicity. Low-grade neurological side effects were correlated to the positron activity measured in the spine. The biological washout of the activity from the tumor volume was dependent on the dose, indicating a potential component of vascular damage at high doses. This experiment marks the first instance of tumor treatment using RIB and paves the way for future clinical applications.
Orogastric Exposure of Cynomolgus Macaques to Bovine HPAI H5N1 Virus Results in Subclinical Infection
Authors: Feldmann Heinz , Rosenke Kyle , Griffin Amanda , Kaiser Franziska , Altynova Ekaterina , Mukesh Reshma , Flagg Meaghan , Tipih Thomas , Goldin Kerry , Wickenhagen Arthur , Williamson Brandi , Gallogly Shane , Leventhal Shanna , Lutterman Tessa , Okumura Atsuhi , Lewis Matthew , Yinda Claude Kwe , Rao Deepashri , Smith Brian , Shaia Carl , Saturday Greg , Hanley Patrick , Doremalen Neeltje van , de Wit Emmie , Munster Vincent 
Published: October 2024

Abstract

Since early 2022 highly pathogenic avian influenza (HPAI) H5N1 virus infections have been reported in wild aquatic birds and poultry throughout the United States (US) with spillover into several mammalian species1-6. In March 2024, HPAIV H5N1 clade 2.3.4.4b was first detected in dairy cows in Texas, US currently affecting more than 190 dairy farms in 14 states7,8. Milk production and quality are diminished in infected dairy cows, with high virus titers in milk raising concerns of exposure through consumption9-12. Here we investigated routes of infection with HPAIV H5N1 clade 2.3.4.4b in cynomolgus macaques, a surrogate model for human infection13. We show that intranasal or intratracheal inoculation of macaques caused systemic infection resulting in mild and severe respiratory disease, respectively. In contrast, infection by the orogastric route resulted in limited infection and seroconversion of macaques which remained subclinical. The study shows that consumption of contaminated products, such as milk, may lead to self-limiting, subclinical infection in primates.
The core competencies in disaster nursing and influencing factors among clinical nurses in Guangzhou: a cross-sectional study based on latent profile analysis
Authors: Ma Chaoqun , Zhang Qishan , Wen Gongzhen , Weng Danting , He Pingjuan , Lai Jinjia , Chen Hanxi , Deng Shaojuan , Deng Qiuying , Tan Yibing 
Published: October 2024

Abstract

ObjectiveTo explore the core competencies in disaster nursing possessed by clinical nurses in Guangzhou, China, and then to uncover the influencing factors that shape these competencies.
Methods A cross-sectional design of 1,151 nurses from Guangzhou was conducted from December 2022 to February 2023.A localized scale was compiled to construct a measurement tool that conforms to international standards and China's actual situation, providing guidance for analyzing capability shortcomings and constructing training programs and improving the disaster response level of Chinese nurses. Latent Profile Analysis (LPA), univariate analysis, and multivariate logistic regression analysis was conducted to explore the predictors of latent profile membership and their influencing factors.
Results A total of 1151 questionnaires were valid.The core competencies of nurses were categorized into three distinct groups: deficient competence group(62.6%),moderate competence group(26.6%), and acceptable competence group(16.9%).Factors such as participation in disaster relief, drills, and belonging to emergency/disaster medical response teams were found to be significant influences.
ConclusionHeterogeneity exists in the core competencies of disaster nursing among nurses in Guangzhou, with the moderate competence group scoring the highest in the legal and ethical dimensions. This study recommends the implementation of targeted training programs and multidisciplinary drills to enhance the capabilities of nurses.
Salidroside protect renal function against inflammation and oxidative stress by NF-κB p65/NLRP3 pathway signaling in streptozocin induced diabetic nephropathy mice
Authors: Zhao Shu-ming , Liu Ling-yu , He Zhuo-en , Zhang Chi , Wang Hao , He Jin-yue , Wang Ming-qing , Wei Lian-bo , Hu Rong 
Published: October 2024

Abstract

Inflammation and oxidative stress have been reported to be a common product of many pathways that are involved in the pathogenesis of diabetic nephropathy. Salidroside, the major active compound in Rhodiola, provide multiple biological activities and has protective effects for alleviating diabetic renal dysfunction. However, the involved molecular mechanism was still not clarified well. In this study, we intended to explore the protective effects and further mechanism of salidroside in STZ-induced diabetic mice. Biochemical analysis was processed to investigate the anti-inflammatory effects and antioxidative effects in serum and kidney homogenate. Thus, the results showed that salidroside effectively reduced the level of blood glucose and GSP, ameliorated the renal function and kidney fibrosis in STZ-induced DN mice. STZ induced inflammation and oxidative stress in mice, which aggravated renal injury. Salidroside also suppressed the expression of proinflammatory factors (including IL-1, IL-1β, TNF-α) and the decreased MDA level, but increased the level of CAT, GSH-Px and SOD activity in STZ-induced mice. In mechanism, salidroside inhibited the expression of NF-κB p65 and NLRP3 pathway related proteins in vivo. Our findings suggest that salidroside improved renal inflammation and oxidative stress by inhibiting p65 and NLRP3 expression in STZ-induced diabetic mice. Our study provides a new potential treatment on diabetic nephropathy.
Comparative Analysis of AI-Generated Research Content: Evaluating ChatGPT and Google Gemini
Authors: Akhoon Irfan ul haq , Khan Mashood Yousuf , Bhat Tajamul Ahmad 
Published: October 2024

Abstract

Background:
The advent of Natural Language Generation (NLG) models like ChatGPT and Google Bard has transformed academic writing by automating the creation of research articles. This study aims to evaluate the effectiveness of these AI tools in academic content generation, with a focus on their authenticity, relevance, and potential for plagiarism. Additionally, it explores the ethical concerns associated with AI-generated research articles.
Methods:
The research employs a comparative analysis of articles generated by ChatGPT and Google Gemini, using Turnitin, a plagiarism detection tool, to assess the originality of the content. Key parameters, such as citation accuracy, reference authenticity, and the similarity index, were examined to evaluate the validity and ethical use of these AI tools.
Results:
The findings reveal that while ChatGPT and Google Gemini generate coherent articles, both tools frequently produce fabricated citations and references. ChatGPT adhered to APA citation styles but used non-existent sources, while Google Gemini presented some authentic sources but failed to follow proper citation formats. The similarity index for AI-generated content was lower than anticipated, but the repetition of limited sources compromised the comprehensiveness of the work.
Conclusion:
AI tools like ChatGPT and Google Gemini hold potential for streamlining research article generation, but human supervision remains critical. The study emphasizes the need for ethical guidelines and robust content verification methods to mitigate issues such as plagiarism and fabricated data. Researchers and institutions are encouraged to adopt AI tools responsibly, ensuring their use enhances academic integrity rather than undermines it.
Productivity and quality of beet (Beta vulgaris L.) under different drip irrigation management methodologies
Authors: Azevedo Angelo Tiago , Coelho Rubens Duarte , Barros Timóteo Herculino Silva 
Published: October 2024

Abstract

Water management in irrigated agriculture, aiming for the sustainability of the activity, faces significant challenges in a scenario of water scarcity, associated with high electricity costs for pump operation and irrigation water rights. This study evaluated the effects of different irrigation management techniques on beetroot (Beta vulgaris L.) productivity and quality in a controlled environment. Climate-based methods (weather station, evaporation pan), soil-based methods (capacitive moisture sensors, tensiometry), and commercial methods were compared, revealing significant variability in applied water (132–408 mm), yield (53–88 tons ha− 1), and water use efficiency (20.4–45.2 kg m− 3). Soil-based methods, particularly the SoilWatch sensor, resulted in the highest productivity and quality, while tensiometry demonstrated superior water use efficiency. Climate-based methods showed potential but required precise parameter calibration. The commercial method, while productive, exhibited lower water use efficiency with its default settings. The study underscores the importance of integrating real-time soil moisture monitoring for optimal irrigation management in beetroot cultivation, emphasizing the need to tailor strategies based on specific crop and environmental conditions.
Sexual and reproductive health of Rohingya refugees in Bangladesh: A systematic review
Authors: Hossain Muhammad Anwar , Sawleshwarkar Shailendra , Zablotska-Manos Iryna 
Published: October 2024

Abstract

The Rohingya refugees in Bangladesh, a severely persecuted ethnic minority of Myanmar, face numerous challenges related to their sexual and reproductive health (SRH), including access to appropriate services. This systematic review examines the SRH status of Rohingya refugee women in Bangladesh, focusing on barriers to accessing SRH services and interventions to address their specific SRH needs. Following PRISMA guidelines, a systematic search was conducted across databases, including PubMed, CINAHL, Embase, Web of Science, and Scopus, as well as gray literature, from August 2017 to July 2023. Both quantitative and qualitative studies were included, with data extraction and analysis performed independently by two authors using a narrative synthesis approach. Out of 394 citations, ten studies met the criteria. The findings revealed that 48.9% of Rohingya women were unaware of SRH service access, only 11% received frequent (once fortnightly) visits by family planning personnel, 70% lacked knowledge about HIV/STIs, and over two-thirds believed that family planning required husband approval. The prevalence of contraceptive use was 50.9%, with cultural and religious beliefs and gender dynamics significantly influencing family size decisions. The review emphasizes the need for comprehensive, community-based interventions, including door-to-door visits, culturally tailored outreach programs, and SRH education within refugee camps. To address the SRH needs of Rohingya women, adopting a multifaceted approach that promotes SRH education, improves service accessibility, and empowers women to make informed reproductive choices is essential.
Registration: This review is registered with PROSPERO under the ID CRD42023444386.
First-trimester DNA Methylome profiling identifies novel predictors for gestational diabetes mellitus in Indian women
Authors: Gokulakrishnan Kuppan , Thirumoorthy Chinnasamy , Sharma Kuldeep , Ram Uma , Deepa Mohan , Weldeselassie Yonas , Asres Hailemariam , Venkatesh U , Binukumar B , Radha Venkatesan , Popova Polina , Sharma Sapna , Grallert Harald , Anjana Ranjit Mohan , Balasubramanyam Muthuswamy , Tandon Nikhil , Mohan Viswanathan , Saravanan Ponnusamy 
Published: October 2024

Abstract

Gestational diabetes mellitus (GDM) poses significant health risks for both mothers and offspring, necessitating early detection strategies. We aimed to identify specific DNA methylation signatures in early pregnancy to enhance GDM prediction. We quantified the Epigenome-wide DNA methylation profiles in 258 individuals with normal fasting glucose at early pregnancy (< 16 weeks), of whom 43% (n=111) developed GDM. We identified a panel of five CpGs (cg10139015, cg23507676, cg11001216, cg04539775, cg04985016) that predicted GDM with an area under the curve (AUC) of 0.82 (sensitivity: 82% and specificity: 77%). Combining these CpGs with maternal risk factors (age, waist-height ratio, family history of diabetes, HbA1c, and blood pressure) achieved the highest predictive ability (AUC = 0.86). Our findings suggest that a panel of 5 CpGs exhibits robust predictive value, highlighting the feasibility of creating a CpG panel to predict GDM as early as the first trimester. This has the potential to enhance diagnostic and preventive strategies for GDM.
The evolution of the Canadian (CCME) Water Quality Index
Authors: Swain Leslie Grant 
Published: October 2024

ABSTRACT
This paper explores the development of the Canadian Water Quality Index (CWQI) from its origins in British Columbia through to the final formulation. The CWQI was adopted in Canada in 2003 by the National Round Table on the Environment and Economy as one of six indicators for reporting on natural capital to Canadians. CWQI values are compared between 2002 and 2022. The trend in water quality between the first year that data were reported for each site and 2022 at 160 sites across southern Canada showed that there was at least some deterioration at 41% of sites, no change at 48% of sites, and an improvement in quality at 11% of the 160 sites.
Actively Learning and Practicing Ethical Stewardship
Authors: Buchanan Sarah A. , Fritz Angela , Gunn Chelsea , Hirschy Jeff , Pucciarelli Alexandra N. , Thaler Jane , Thaxton Mahogany 
Published: October 2024

The Archival / Preservation Education SIG session offers pedagogical insights on master’s-level information science and archival education. Five ten-minute individual presentations and audience discussion explore educators’ active learning activities; presenters bring perspectives from multiple states.
“Teaching and Practicing Ethical Stewardship” by Sarah Buchanan reflects on graduate archival classroom experiences with the lodestar of ethical stewardship.
“Exploring Digitized GLAM Collections through the Lens of Critical Data Literacy” by Angela Fritz shares some active learning principles that have provided an instructional framework for the critical analysis of digitized collections in graduate classes focusing on archives and digital preservation.
“The Interconnected Educational World of Archives” by Jeff Hirschy presents a pedagogical argument for breaking down the rigidity of “correct” archival boxes in the archival educational space.
“Fostering Inclusivity: A Comprehensive Exploration of Disability Justice in Information Institution” by Alexandra Pucciarelli proposes approaches to integrate disability justice into archival education.
“Connecting Curriculum to Community: Findings and Recommendations from the Classroom” by Chelsea Gunn, Jane Thaler, and Mahogany Thaxton outlines insights and findings from interviews with community archivists in Pittsburgh conducted during the Connecting Curriculum to Community project.
The moderator will facilitate Q&A within and across the presentations.
On the issue of complications following excimer laser correction of ametropia
Authors: Mogilevskyy S.Yu. , Lysenko N.R. 
Published: October 2024

Background. Diffuse lamellar keratitis is a rare yet severe postoperative complication that may arise following excimer laser correction of myopia. Research indicate that the incidence of this condition after LASIK ranges from 4.3 to 18.9 %, and after FemtoLASIK, it varies from 0.5 % to more than 37.5 %. Given the increasing popularity of LASIK and FemtoLASIK technologies, studying the frequency and clinical characteristics of this complication is crucial for enhancing treatment outcomes and patient safety. This study purposed to explore the clinical course and frequency of diffuse lamellar keratitis following different excimer laser technologies used for myopia correction. Materials and methods. We conducted a prospective, cohort, non-interventional study. It involved 180 patients (360 eyes) who underwent myopia correction using either LASIK (182 eyes) or FemtoLASIK (178 eyes). Postoperative monitoring included visual acuity, refraction, and biomicroscopy to identify potential complications, particularly diffuse lamellar keratitis. We examined the frequency and clinical course of the condition after each type of excimer laser correction. The observation period is 1 year. Results. Upon examination one week after excimer laser correction, the incidence of diffuse lamellar keratitis in the first group was 4.95 %, while in the second group it was 6.74 %. One month after surgery, there was a reduction in the frequency of diffuse lamellar keratitis: in the first group, it decreased to 3.30 %, and in the second group, to 2.81 %. By the three-month follow-up, the first group showed no manifestations of diffuse lamellar keratitis, whereas the second group had an incidence of 0.56 %. At the six-month follow-up, the incidence in the first group was 0.55 %, and there were no clinical manifestations of diffuse lamellar keratitis in the second group. At the one-year follow-up, neither group exhi­bited clinical signs of this disease. The clinical course and manifestations of diffuse lamellar keratitis did not differ between LASIK and FemtoLASIK throughout the study period. Additionally, it was found that 38.46 % of the patients had a history of SARS-CoV-2 infection. Conclusions. Our research revealed that the frequency of diffuse lamellar keratitis was 6.3 % after LASIK and 6.6 % after FemtoLASIK over a 1-year period. The clinical course and manifestations of the condition were similar for both LASIK and FemtoLASIK at all observation points. In was found that 38.46 % of patients who developed diffuse lamellar keratitis after excimer laser correction had a history of SARS-CoV-2 infection (from 2 weeks to 2 months). Future research should focus on investigating new local (ocular) and systemic (whole body) pathogenetic factors of diffuse lamellar keratitis following modern excimer laser methods for ametropia correction.
3D Printed Dual Reduction Guide: A Feasible Alternative for Conservative Gingivectomy and Minimally Invasive Preparation for Ceramic Veneers
Authors: Robles M , Jurado CA , Fischer NG , Rojas-Rueda S , Apiazu-Flores FX 
Published: October 2024

SUMMARY

Objectives:
This case report describes a digital workflow for designing and 3D printing a guide with the dual purpose of gingivectomy and tooth preparation in the esthetic zone, to be followed by cementation of ceramic veneers under rubber dam isolation.

Clinical Considerations:
The patient’s primary concern was to improve her smile. After clinical evaluation, our recommendation was for a minimal gingivectomy to match the gingival zenith for both central incisors, to be followed by ceramic laminate veneers. A digitally designed and 3D printed guide was used for gingivectomy and tooth preparation for the ceramic veneers. Ceramic veneers were cemented under rubber dam isolation to maximize bonding properties.

Conclusions:
A single guide can be digitally designed and 3D printed to perform controlled gingivectomy and minimally invasive tooth preparations. The outcome of the gingivectomy improved the gingival architecture for central incisors, and the ceramic veneers fulfilled the patient’s esthetic demands.
Biomechanical and Physical Characteristics of Dental Dam Sheets Used for Absolute Isolation
Authors: Lozada MIT , Junqueira PCB , Rondón AKA , Carlo HL , Soares CJ 
Published: October 2024

SUMMARY

Objective:
This study aimed to evaluate the mechanical and physical properties of dental dam sheets used for absolute isolation and to correlate the mechanical parameters with cost.

Methods and Materials:
Twenty-one dental dam sheets were tested: ALLPRIME; Madeitex; Sanctuary non-latex, Sanctuary latex black, green, and blue; Nic Tone blue and black; Mk Life; Elastidam; Bassi; Pribanic; Care; OK; MDC Dental; Keystone; Dura Dam; Flexidam; Sanctuary blue; Nic Tone blue; Ehros; and USE. The thicknesses of the dental dam sheets were measured using a digital micrometer (Mitutoyo). The dental dam sheets (n=15) were prepared by cutting the samples with dimensions of 80 × 10 mm with a 1.7 mm hole made at the center of each specimen, following the ISO 9001 standard. The specimens were tested using a universal testing machine (Emic) at a speed of 500 mm/min until rupture to calculate rupture force (RF, N), elongation (%), and ultimate tensile strength (UTS, MPa), their thickness (mm) was measured using a digital micrometer, and scanning electron microscopy and X-ray energy dispersive spectroscopy were performed to analyze the structure and composition. The radiopacity was measured using digital radiography. Thickness, UTS, RF, and elongation data were analyzed by one-way ANOVA and Tukey's test (α=0.05).

Results:
The Flexidam dental dam had the largest thickness (0.5 mm), while Nic Tone had a median thickness of 0.3 mm; the RF value (41.3 N) was higher for the thicker dental dams. The other dental dams had RF values ranging from 19 to 30 N. The highest elongation was obtained for the non-latex Sanctuary dental dam (600 mm). The Bassi dental dam had the highest UTS value (15 MPa), and medium and small particles were observed in most of the gums. A loss of continuity was detected in the structure of Sanctuary green and blue media. The predominant elements in the sheets were carbon, magnesium, sulfur, silicon, and calcium.

Conclusions:
The UTS, RF, and elongation varied substantially, indicating insufficient standardization of dental dam sheets. Nonetheless, most of the tested dental dams exhibited mechanical and physical properties suitable for clinical use. The correlation between the cost and mechanical properties of the dental dams was very low.