bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação da migração do espaçador intersomático (cage) em pacientes submetidos à artrodese lombar pela técnica TLIF
Authors: Rezende Rodrigo , Junqueira de Faria Fernando , Pinto Igor Pellucci , Batista Júnior José Lucas , Júnior Chárbel Jacob , Cardoso Igor Machado 
Published: January 2018

Resumo
Objetivo: Avaliar a migração do espaçador intersomático (cage) em pacientes submetidos à artrodese lombar pela técnica transforaminal (TLIF). Método: Estudo retrospectivo de 27 pacientes submetidos à técnica TLIF nos níveis L4-L5, L5-S1 ou L4-L5 e L5-S1 para tratamento de patologia degenerativa da coluna lombar entre julho de 2009 e julho de 2011. Os dados referentes à migração do cage foram obtidos a partir da análise de imagens radiográficas da coluna lombar nas incidências anteroposterior (AP) e perfil nos momentos pré e pós-operatório com 1, 6 e 12 meses. O valor utilizado como critério de migração do cage foi determinado pelo deslocamento anterior ou posterior maior ou igual a 2 mm quando comparado a exame radiográfico pré e pós-operatório. Resultados: Foi inserido um total de 36 cages. Dos 27 pacientes avaliados, 15 (55,5%) apresentavam algum tipo de migração do cage – em 4 (14,8%) a migração foi para anterior e em 11 (40,7%) a migração foi para posterior. Conclusão: Encontramos migração em 55,5% do total de pacientes, e em 40,7% a migração foi posterior, porém sem necessidade de novas intervenções cirúrgicas.
Intratumoral hemorrhage and deadly upward transtentorial herniation after endoscopic third ventriculostomy in the management of posterior fossa tumor-related hydrocephalus – Case report and literature review
Authors: Parreira Johnathan de Sousa , Ferreira Adelmo , Antonucci Adriano Torres , Santiago Natally Marques , Neto Roberto Parente , Oliveira Bruno de Azevedo , Garcia Lopes Luiz Henrique , Lopes Pedro Garcia 
Published: January 2018

AbstractThe management of hydrocephalus associated with posterior fossa tumors in children has always been controversial. Studies show that 71%-90% of children with posterior fossa tumors already presented hydrocephalus on admission. Of these cases, 10%-62% will have persistent hydrocephalus after surgical treatment of the tumor. The shunt, although it is an important alternative for preoperative treatment in these cases is not without complications. Among the numerous complications identified by the literature, we highlight the most rare, intratumoral hemorrhage, upward transtentorial herniation and dissemination of neoplastic cells by the peritoneum. Medulloblastoma is considered the most common malignant pediatric tumor, comprising 15%-20% of all intracranial tumors in childhood. In addition, 5%-6% of primary or recurrent medulloblastomas may be associated with spontaneous bleeding and rapid deterioration. The bleeding presents with tumor swelling, extending to the ventricular system through the tumor capsule, increased intracranial pressure and upward transtentorial herniation. Tumoral hemorrhage associated with ventricular drainage for treatment of hydrocephalus in patients with medulloblastoma represents an extremely rare phenomenon. The endoscopy third-ventriculostomy (ETV) is known to be very useful in the treatment of intracranial hypertension preoperatively and prevent persistent postoperative hydrocephalus in cases associated with posterior fossa tumors, with efficacy superior to traditional ventricular shunts. We describe a case of intratumoral hemorrhage and upward transtentorial herniation associated with endoscopic third-ventriculostomy (ETV).
Intraventricular hemorrhage secondary to AVM of the septum pellucidum
Authors: Maranha Gatto Luana Antunes , Corredato Renata de Angeli , Zanine Simone Cristina , Araújo João Cândido , Diaz Fernando Gustavo 
Published: January 2018

AbstractArteriovenous malformations (AVMs) of the brain include congenital vascular lesions that represent about 2% of all hemorrhagic strokes. Despite the relative rarity of the disease (with a detection rate estimated at approximately 1/100.000 person-years), AVMs represent a significant neurological problem. Affected patients are mostly young and healthy. AVMs located in the medial region of the cerebral hemisphere and the limbic system comprise a special group with difficult access and consequent difficulties of resection. Furthermore, there is a high incidence of intracranial hemorrhage resulting from a complex venous drainage, sometimes directed to the superficial veins, but mostly to the deep venous system. The present case report illustrates a patient with an AVM centered on the septum pellucidum, whose initial clinical resulted from an intra-ventricular hemorrhage.
Carcinoma adenoide cístico intracraniano
Authors: Welling Leonardo C. , Lynch José Carlos , Andrade Ricardo , Pereira Celestino Esteves , Hidalgo Fabiana , Corrêa Juliano , Kaskus Lúcia 
Published: January 2018

ResumoOs carcinomas adenoides císticos são tumores de crescimento lento, localmente agressivos e com tendência à recorrência. Têm particular interesse por infiltrar estruturas neurais e disseminar-se pelo perineuro. Envolvimento intracraniano é raro. Descreve-se um caso de carcinoma adenoide cístico originado na glândula lacrimal esquerda e invasão do seio cavernoso. Ressonância magnética demonstrou lesão tumoral, extra-axial, bem delimitada, semelhante a um meningioma da asa do esfenoide com invasão do seio cavernoso. O paciente apresentou boa resposta ao tratamento com cirurgia e radioterapia complementar.
Rosai-Dorfman primário do sistema nervoso central simulando meningioma de tórcula: relato de caso
Authors: Rossato Costa Luís Eduardo , de Carvalho Anderson Rafael Figueiredo , Hinojosa Dorado Juan Jose , Silva Matos Cleomir da , Raid Denis Esteves , de Brito Arcelino Vital , Collado Rusdany Fuentes , Pedrosa Grangeiro Cecília Rondon , Martinez Palhares Antônio Eduardo , Santos Franco Emily dos 
Published: January 2018

ResumoRelatamos o caso de uma mulher de 65 anos de idade, com queixa de cefaleia, portadora de uma lesão expansiva em região posterior da tenda do cerebelo, implantado na tórcula, sugestivo de meningioma pelos exames de imagens, foi submetida ao tratamento neurocirúrgico para ressecção. Ao exame anatomopatológico, foi sugerido diagnóstico de doença de Rosai-Dorfman, confirmado pela imuno-histoquímica. Trata-se de uma rara linfadenopatia proliferativa histiocítica, de comportamento benigno, com acometimento mais frequente da cadeia linfonodal cervical e outros sítios extranodais, sendo extremamente rara sua localização no sistema nervoso central, principalmente na fossa posterior, sem acometimento de outras estruturas anatômicas.
Hematoma intradiploico: tratamento cirúrgico e relato de caso
Authors: Amoreira Gepp Ricardo de , Neri Eidmar Augusto , Junior Altamir Monteiro , Kalil Ricardo Karam 
Published: January 2018

ResumoO hematoma intradiploico é uma lesão rara do crânio. Foi descrita inicialmente em 1934 e até hoje a sua patogênese não é conhecida. Trata-se de uma lesão rara e secundária a um processo reativo benigno após traumas cranianos leves ou coagulopatias. Paciente de 42 anos apresentava quadro progressivo de perda da marcha e alteração visual. Foi identificada massa na região occipital do paciente, de caráter progressivo. Os estudos radiológicos demonstravam lesão de aspecto heterogêneo, erosiva da calota craniana e com expansão intracraniana. Realizou angiografia digital que demonstrou trombose de seio sagital superior. Foi submetido à biópsia seguida de ressecção da lesão associada à cranioplastia. Houve melhora do padrão visual e do desempenho de marcha do paciente, em relação ao pré-operatório. Os autores relatam um caso raro de hematoma intradiploico, analisaram os diagnósticos diferenciais e discutem as opções cirúrgicas dessa rara doença.
Low Aromatase Activity and Estradiol/Sex Hormone Binding Globulin Ratio are Associated with Total Hip Bone Mineral Density and the Presence of Osteoporosis: A Study in Chinese Postmenopausal Women
Authors: Liu Hai-Juan , Yan Jun , Li Yan , Zhou Fang-Yuan , Su Xu-Dong , Fan Hui-jing , Bai Jie , Zhang Guang-Zhen 
Published: January 2018

AbstractSeveral groups have reported the important role of estradiol (E2) and testosterone (T) in postmenopausal osteoporosis (PMOP). Because aromatase catalyzes the conversion of T to E2, the purpose of this study was to determine the influence of aromatase activity on the bone mineral density (BMD) in postmenopausal women. A total of 344 postmenopausal women were selected for this study. Serum E2, T, sex hormone-binding globulin (SHBG), calcium (Ca), alkaline phosphatase (ALP), C-terminal telopeptide of type I collagen (CTX), and procollagen type I amino-terminal propeptide (PINP) were examined. The E2/T was positively associated with total hip BMD and PINP (p<0.05). When E2/T was divided into quartiles, participants in lower quartiles of E2/T were likely to have higher PINP and lower BMD (p<0.05). The prevalence of osteoporosis significantly increased as E2/T ratio decreased. The receiver operating characteristic (ROC) curves were constructed for serum E2, free E2 index (FEI), and E2/T, to assess their diagnostic accuracy in PMOP. The overall area under the curve (AUC) were 0.83 (95% CI=0.77–0.88) for E2, 0.87 (95% CI=0.82–0.92) for FEI, and 0.89 (95% CI=0.85–0.94), respectively. In conclusion, the study suggests that in postmenopausal women, aromatase activity could be an important determinant of skeletal health. The women with lower aromatase activity may have greater likelihood of PMOP and the E2/T was expected to be a valuable indicator for the prediction of PMOP and to monitor the process of osteoporosis.
A comparison of endoscopic and non-endoscopic biliary intervention outcomes in patients with prior bariatric surgery
Authors: Kamboj Amrit , Pidlaoan Victorio , Shakhatreh Mohammad , Hinton Alice , Conwell Darwin , Krishna Somashekar 
Published: January 2018

Abstract
Background and study aims Endoscopic biliary intervention (BI) is often difficult to perform in patients with prior bariatric surgery (BRS). We sought to analyze outcomes of patients with prior BRS undergoing endoscopic and non-endoscopic BI.
Patients and methods The Nationwide Inpatient Sample (2007 – 2011) was reviewed to identify all adult inpatients (≥ 18 years) with a history of BRS undergoing BI. The clinical outcomes of interest were in-patient mortality, length of stay (LOS), and total hospital charges.
Results There were 7,343 patients with prior BRS who underwent BIs where a majority were endoscopic (4,482 vs. 2,861, P < 0.01). The mean age was 50±30.8 years and the majority were females (80.5 %). Gallstone-related disease was the most common indication for BI and managed more often with primary endoscopic management (2,146 vs. 1,132, P < 0.01). Inpatient mortality was not significantly different between patients undergoing primary endoscopic versus non-endoscopic BI (0.2 % vs. 0.7 %, P = 0.2). Patients with sepsis were significantly more likely to incur failed primary endoscopic BI (OR 2.74, 95 % CI 1.15, 6.53) and were more likely to be managed with non-endoscopic BI (OR 2.13, 95 % CI 1.3, 3.5). Primary non-endoscopic BI and failed endoscopic BI were both associated with longer LOS (by 1.77 days, P < 0.01 and by 2.17 days, P < 0.01, respectively) and higher hospitals charges (by $11,400, P < 0.01 and by $ 14,200, P < 0.01, respectively).
Conclusion Primary endoscopic management may be a safe and cost-effective approach for patients with prior BRS who need BI. While primary endoscopic biliary intervention is more common, primary non-endoscopic intervention may be used more often for sepsis.
Efficacy and safety of sedation during endoscopic submucosal dissection of gastric cancers using a comparative trial of propofol versus midazolam
Authors: Kikuchi Hitomi , Hikichi Takuto , Watanabe Ko , Nakamura Jun , Takagi Tadayuki , Suzuki Rei , Sugimoto Mitsuru , Waragai Yuichi , Konno Naoki , Asama Hiroyuki , Takasumi Mika , Sato Yuki , Obara Katsutoshi , Ohira Hiromasa 
Published: January 2018

Abstract
Background and study aims Proper sedation is necessary for the safe and satisfactory completion of endoscopic submucosal dissection (ESD) for early gastric cancer. This study was conducted as a comparative trial of efficacy and safety, comparing propofol-based sedation and midazolam-based sedation during ESD of early gastric cancer patients.
Patients and methods This study examined 64 lesions in 58 patients treated using ESD with midazolam plus pentazocine between July 2013 and January 2014 (group M) and 237 lesions in 216 patients treated by ESD using propofol plus pentazocine between February 2014 and December 2015 (group P). The two groups were compared in terms of the frequency of body movement during ESD as the primary outcome and in terms of the procedure time, en bloc resection rate, intraoperative change in cardiorespiratory dynamics, and postoperative awareness as the secondary outcomes. Body movement was defined as movement by a patient that required interruption of the procedure or restraint of the patient’s body trunk, and addition of a sedative agent.
Results The median frequency of body movement during ESD was significantly lower in group P (0 times) than in group M (3 times) (P < 0.001). No significant difference was found for the mean procedure time (117 min in group P; 127 min in group M). Although no significant difference was found in the incidence of hypoxemia, bradycardia, or bradypnea, the incidence of hypotension was significantly higher in group P (31.5 %) than in group M (6.9 %) (P = 0.004). Patients in group P had significantly higher postoperative awareness immediately after ESD and at 1 hour after ESD (P = 0.002 and 0.022, respectively).
Conclusion These results demonstrate the efficacy and safety of propofol-based sedation for gastric ESD.
The chronotopes of authenticity
Authors: Wang Xuan , Kroon Sjaak 
Published: January 2018

Abstract
This paper examines the ways in which the ethnic minority group the Tujia in Enshi, China, engages with heritage tourism, as a complex project of designing authenticity. Authenticity is taken as part of the chronotopic phenomena of identity making: the complex interplay of multiple, nonrandom timespace frames of discourses and semiotic performances which condition and offer new potentials to the meanings of authenticity. We show ethnographically the chronotopic nature of the local production of “authentic” heritage for tourism in Enshi. This leads to a historical grounding of the Tujia in China’s nation-building and state politics of multiculturalism, which uncovers the anxiety of inauthenticity experienced by the Tujia in Enshi with their own minority status and cultural heritage, as well as their strategic chronotopic incorporation of both “authentic” and “inauthentic” aspects of local identity practices into a new order of authenticity afforded by heritage tourism as a form of new economy. Through such practices, we argue, the Tujia in Enshi chronotopically shift away from the periphery towards a new and reconfigured center of meaning-making, although this reappropriation of authenticity still must be understood within the “cunning of recognition” scheme, i.e. within the constraints of late modernity.
Challenge from the margins
Authors: Ballena Camilo , Unamuno Virginia 
Published: January 2018

Abstract
This paper explores the production of new meanings linked to written practices in the Wichi language in the Impenetrable Chaqueño (Argentina). Through collaborative ethnography examining different collective experiences and points of view, we study changes in writing in connection with changes in the access, distribution and availability of written practices in the Wichi language, and particularly in connection with social processes that position the Wichi people as key agents. Voice and agency are considered in order to explain meaning-making of language practices that are central but at the same time peripheral, and which seem to challenge, from the margins, social relationships between languages and people that hitherto seemed to be immovable.
Optimal water networks in protein cavities with GAsol and 3D-RISM
Authors: Fusani Lucia , Wall Ian , Palmer David , Cortes Alvaro 
Published: January 2018

Abstract

Motivation
Water molecules in protein binding sites play essential roles in biological processes. The popular 3D-RISM prediction method can calculate the solvent density distribution within minutes, but is difficult to convert it into explicit water molecules.

Results
We present GAsol, a tool that is capable of finding the network of water molecules that best fits a particular 3D-RISM density distribution in a fast and accurate manner and that outperforms other available tools by finding the globally optimal solution thanks to its genetic algorithm.

Availability and implementation
https://github.com/accsc/GAsol. BSD 3-clauses license

Supplementary information
Supplementary data are available at Bioinformatics online.
Overdose Education and Naloxone Distribution Programmes and the Ethics of Task Shifting
Authors: Buchman Daniel Z , Orkin Aaron M , Strike Carol , Upshur Ross E G 
Published: January 2018

AbstractNorth America is in the grips of an epidemic of opioid-related poisonings. Overdose education and naloxone distribution (OEND) programmes emerged as an option for structurally vulnerable populations who could not or would not access mainstream emergency medical services in the event of an overdose. These task shifting programmes utilize lay persons to deliver opioid resuscitation in the context of longstanding stigmatization and marginalization from mainstream healthcare services. OEND programmes exist at the intersection of harm reduction and emergency services. One goal of OEND programmes is to help redress the health-related inequities common among people who use drugs, which include minimizing the gap between people who use drugs and the formal healthcare system. However, if this goal is not achieved these inequities may be entrenched. In this article, we consider the ethical promises and perils associated with OEND as task shifting. We argue that public health practitioners must consider the ethical aspects of task shifting programmes that may inadvertently harm already structurally vulnerable populations. We believe that even if OEND programmes reduce opioid-related deaths, we nevertheless question if, by virtue of its existence, OEND programmes might also unintentionally disenfranchise structurally vulnerable populations from comprehensive healthcare services, including mainstream emergency care.
CE: Managing Sepsis and Septic Shock: Current Guidelines and Definitions
Authors: Makic Mary Beth Flynn , Bridges Elizabeth 
Published: January 2018

Sepsis is a leading cause of critical illness and hospital mortality. Early recognition and intervention are essential for the survival of patients with this syndrome. In 2002, the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM) launched the Surviving Sepsis Campaign (SSC) to reduce overall patient morbidity and mortality from sepsis and septic shock by driving practice initiatives based on current best evidence. The SSC guidelines have been updated every four years, with the most recent update completed in 2016. The new guidelines have increased the focus on early identification of infection, risks for sepsis and septic shock, rapid antibiotic administration, and aggressive fluid resuscitation to restore tissue perfusion.
In 2014, the SCCM and the ESICM convened a task force of specialists to reexamine the definitions of terms used to identify patients along the sepsis continuum. In 2016, this task force published the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). The new definitions and recommendations included tools, based on an updated understanding of the pathobiology of sepsis, that can be used to predict adverse outcomes in patients with infection.
This article discusses the new SSC treatment guidelines, changes in the sepsis bundle interventions, and the Sepsis-3 definitions and tools, all of which enable nurses to improve patient outcomes through timely collaborative action.
Master protocols in lung cancer: experience from Lung Master Protocol
Authors: Lam Vincent K. , Papadimitrakopoulou Vassiliki 
Published: January 2018

Purpose of review
Contemporary advances in the understanding of the molecular and immunologic basis of metastatic lung cancer have firmly changed its treatment paradigm to a personalized, biomarker-driven approach. However, the majority of lung-cancer patients [especially lung squamous cell carcinoma (LUSC)] still do not have effective targeted therapeutic options. Master protocols, such as Lung-MAP, represent an innovative clinical trial approach designed to accelerate evaluation of novel biomarker-driven therapies.

Recent findings
Lung-MAP is an umbrella trial for advanced LUSC and has been active since 2014. Cumulative experience from this overarching, multi-institution master protocol has demonstrated that centralized, real-time biomarker screening is feasible and substudy modularity is essential for protocol adaptability in a rapidly changing treatment landscape. In addition, screening and efficacy results from Lung-MAP affirm that LUSC has several putative drivers but remains difficult to effectively treat with targeted therapy.

Summary
Master protocols are a feasible and efficient approach for evaluating biomarker-driven therapies in lung cancer. As we begin to target less common genomic and immunotherapy subtypes, centrally coordinated clinical trial designs such as Lung-MAP are necessary to rapidly deliver effective therapies to patients, whereas also maximizing the quality of research data obtained.
Case of Congenital Self-Healing Reticulohistiocytosis Expanding the Spectrum of Blueberry Muffin Baby
Authors: Cano Bará Sara , Vargas-Navia Natalia , Rueda Plata Ricardo 
Published: January 2018

Abstract:
Congenital self-healing reticulohistiocytosis (CSHRH) is a benign, rare variant of histiocytosis. This condition can present phenotypically as blueberry muffin baby. This is the case of a male neonate with skin involvement of papulonodular violaceous lesions, which resolved spontaneously. The diagnosis of CSHRH is confirmed using histopathology and immunohistochemistry.
Severe Intraocular Pressure Elevation After Intracameral Healon 5 Viscoelastic Support for Postoperative Hypotony After XEN Gel Stent Insertion
Authors: Bruynseels Alice , Sii Freda , Masood Imran , Shah Peter 
Published: January 2018

Purpose:
The purpose of this article was to describe (i) a novel case of severe intraocular pressure (IOP) elevation due to intracameral Healon 5 for management of early postoperative (post-op) hypotony following XEN Gel Stent insertion and (ii) the management of this complication.

Materials and Methods:
A case report.

Results:
A 52-year-old man, with primary open-angle glaucoma and suboptimal left IOP control on maximally tolerated medical therapy, was managed with XEN Gel Stent insertion at another tertiary eye unit. Post-op, the IOP was 2 mm Hg with a shallow anterior chamber (AC) and choroidal effusions. Intracameral injections of Provisc on post-op days 1 and 3 failed to reverse hypotony. At 1 week post-op, persistent clinically significant hypotony was managed with Healon 5 injection into the AC. Twelve hours later, the patient experienced significant pain and reduced vision and presented to a different tertiary eye unit, where left visual acuity was hand movements, IOP was 70 mm Hg with a deep AC (complete ophthalmic viscosurgical device fill with Healon 5) and a flat drainage bleb with no external drainage. Emergency AC washout of the Healon 5 was performed with resolution of symptoms, visual acuity, and IOP control.

Conclusions:
We caution against the use of intracameral Healon 5 in the management of post-op hypotony following XEN Gel Stent insertion, given the potential risk for extreme IOP elevation and sight loss.