bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous Tenocyte Injection for the Treatment of Chronic Recalcitrant Gluteal Tendinopathy
Authors: Bucher Thomas A. , Ebert Jay R. , Smith Anne , Breidahl William , Fallon Michael , Wang Tao , Zheng Ming-Hao , Janes Gregory C. 
Published: February 2017

Background: Gluteal tendinopathy is a common cause of lateral hip pain, and existing conservative treatment modalities demonstrate high symptom recurrence rates. Autologous tenocyte injection (ATI) is a promising cell therapy that may be useful for the treatment of gluteal tendinopathy. Purpose: To investigate the safety and effectiveness of ATI, specifically in patients with chronic recalcitrant gluteal tendinopathy. Study Design: Case series; Level of evidence, 4. Methods: Twelve female patients with a clinical and radiological diagnosis of gluteal tendinopathy were recruited. Patients demonstrated a mean duration of symptoms of 33 months (range, 6-144 months), had undergone a mean 3.2 prior corticosteroid injections (range, 2-5), and had failed to respond to existing conservative treatments including physiotherapy and injections. In an initial procedure, tendon cells were harvested from a needle biopsy of the patella tendon and propagated in a certified Good Manufacturing Practice (GMP) laboratory. In a secondary procedure, a single injection of 2 mL autologous tenocytes (2-5 × 106 cells/mL) suspended in patient serum was injected into the site of the pathological gluteal tendons under ultrasound guidance. Patients were assessed pre- and postinjection (3, 6, 12, and 24 months) using the Oxford Hip Score (OHS), a visual analog pain scale (VAS), the Short Form–36 (SF-36), and a satisfaction scale. Magnetic resonance imaging (MRI) was undertaken at 8.7 months (range, 6-12 months) postinjection. Results: Molecular characterization of autologous tendon cells showed a profile of growth factor production in all cases, including platelet-derived growth factor α, fibroblast growth factor β, and transforming growth factor β. The OHS (mean, 24.0 preinjection to 38.9 at 12 months [14.9-point improvement]; 95% CI, 10.6-19.2; P < .001), VAS (mean, 7.2 preinjection to 3.1 at 12 months [4.1-point improvement]; 95% CI, 2.6-5.6; P < .001), and SF-36 (mean, 28.1 preinjection to 43.3 at 12 months [15.2-point improvement]; 95% CI, 9.8-20.5; P < .001) significantly improved to 12 months postinjection, sustained to 24 months. Eight patients were satisfied with their outcomes. Significant MRI-based improvement could not be demonstrated in the majority of cases. Conclusion: ATI for gluteal tendinopathy is safe, with improved and sustained clinical outcomes to 24 months.
The Effect of the Number of Carries on Injury Risk and Subsequent Season’s Performance Among Running Backs in the National Football League
Authors: Kraeutler Matthew J. , Belk John W. , McCarty Eric C. 
Published: February 2017

Background: In recent years, several studies have correlated pitch count with an increased risk for injury among baseball pitchers. However, no studies have attempted to draw a similar conclusion based on number of carries by running backs (RBs) in football. Purpose: To determine whether there is a correlation between number of carries by RBs in the National Football League (NFL) and risk of injury or worsened performance in the subsequent season. Study Design: Cohort study; Level of evidence, 3. Methods: The ESPN NFL statistics archives were searched from the 2004 through 2014 regular seasons. During each season, data were collected on RBs with 150 to 250 carries (group A) and 300+ carries (group B). The following data were collected for each player and compared between groups: number of carries and mean yards per carry during the regular season of interest and the subsequent season, number of games missed due to injury during the season of interest and the subsequent season, and the specific injuries resulting in missed playing time during the subsequent season. Matched-pair t tests were used to compare changes within each group from one season to the next in terms of number of carries, mean yards per carry, and games missed due to injury. Results: During the seasons studied, a total of 275 RBs were included (group A, 212; group B, 63). In group A, 140 RBs (66%) missed at least 1 game the subsequent season due to injury, compared with 31 RBs (49%) in group B ( P = .016). In fact, players in group B missed significantly fewer games due to injury during the season of interest ( P < .0001) as well as the subsequent season ( P < .01). Mean yards per carry was not significantly different between groups in the preceding season ( P = .073) or the subsequent season ( P = .24). Conclusion: NFL RBs with a high number of carries are not placed at greater risk of injury or worsened performance during the subsequent season. These RBs may be generally less injury prone compared with other NFL RBs.
The Temporalis Muscle Flap: A Useful Adjunct in Reconstruction of Combined Defects of the Upper and Lower Eyelids
Authors: Haykal Siba , Antonyshyn Oleh M , Gill Harmeet S 
Published: February 2017

BACKGROUND: Eyelid reconstruction following oncological resection remains a challenge. Multiple techniques have been described for isolated upper or lower eyelid defects. OBJECTIVE: To describe the use of the temporalis flap for reconstruction of an eyelid defect involving both the upper and lower eyelids. METHODS: Excision of a basal cell carcinoma was performed. This resulted in full-thickness defects of the upper and lower eyelids, the lateral canthus including upper and lower canthal tendons, the upper right mid-face, temple, lateral two-thirds of the eyebrow and forehead. The tumour was found to be adherent to bone and dissecting deeply into the lateral orbital cavity as well as along the orbital roof. RESULTS: The lateral orbital rim was reconstructed using the prebent titanium mesh implant. A temporalis muscle flap allowed for draping over the reconstructed orbital rim and to provide reconstruction of the tarsal plates of the upper and lower eyelids. The remaining large cutaneous defect, which involved more than half of the lower eyelid, was reconstructed using a large Mustarde cervical facial rotation flap. CONCLUSIONS: The temporalis muscle flap provides abundant well vascularized tissue and has been described for head and neck reconstruction. A novel technique allows reconstruction of both the upper and lower eyelids using the temporalis muscle in combination with local flaps.
High-quality-draft genome sequence of the fermenting bacterium Anaerobium acetethylicum type strain GluBS11T (DSM 29698)
Authors: Patil Yogita , Müller Nicolai , Schink Bernhard , Whitman William B. , Huntemann Marcel , Clum Alicia , Pillay Manoj , Palaniappan Krishnaveni , Varghese Neha , Mikhailova Natalia , Stamatis Dimitrios , Reddy T. B. K. , Daum Chris , Shapiro Nicole , Ivanova Natalia , Kyrpides Nikos , Woyke Tanja , Junghare Madan 
Published: February 2017

AbstractAnaerobium acetethylicum strain GluBS11T belongs to the family Lachnospiraceae within the order Clostridiales. It is a Gram-positive, non-motile and strictly anaerobic bacterium isolated from biogas slurry that was originally enriched with gluconate as carbon source (Patil, et al., Int J Syst Evol Microbiol 65:3289-3296, 2015). Here we describe the draft genome sequence of strain GluBS11T and provide a detailed insight into its physiological and metabolic features. The draft genome sequence generated 4,609,043 bp, distributed among 105 scaffolds assembled using the SPAdes genome assembler method. It comprises in total 4,132 genes, of which 4,008 were predicted to be protein coding genes, 124 RNA genes and 867 pseudogenes. The G + C content was 43.51 mol %. The annotated genome of strain GluBS11T contains putative genes coding for the pentose phosphate pathway, the Embden-Meyerhoff-Parnas pathway, the Entner-Doudoroff pathway and the tricarboxylic acid cycle. The genome revealed the presence of most of the necessary genes required for the fermentation of glucose and gluconate to acetate, ethanol, and hydrogen gas. However, a candidate gene for production of formate was not identified.
Randomized Phase II Study of Clofarabine-Based Consolidation for Younger Adults With Acute Myeloid Leukemia in First Remission
Authors: Thomas Xavier , de Botton Stéphane , Chevret Sylvie , Caillot Denis , Raffoux Emmanuel , Lemasle Emilie , Marolleau Jean-Pierre , Berthon Céline , Pigneux Arnaud , Vey Norbert , Reman Oumedaly , Simon Marc , Recher Christian , Cahn Jean-Yves , Hermine Olivier , Castaigne Sylvie , Celli-Lebras Karine , Ifrah Norbert , Preudhomme Claude , Terré Christine , Dombret Hervé 
Published: February 2017

Purpose To evaluate the efficacy and safety of a clofarabine-based combination (CLARA) versus conventional high-dose cytarabine (HDAC) as postremission chemotherapy in younger patients with acute myeloid leukemia (AML). Patients and Methods Patients age 18 to 59 years old with intermediate- or unfavorable-risk AML in first remission and no identified donor for allogeneic stem-cell transplantation (SCT) were eligible. Two hundred twenty-one patients were randomly assigned to receive three CLARA or three HDAC consolidation cycles. The primary end point was relapse-free survival (RFS). To handle the confounding effect of SCT that could occur in patients with late donor identification, hazard ratios (HRs) of events were adjusted on the time-dependent treatment × SCT interaction term. Results At 2 years, RFS was 58.5% (95% CI, 49% to 67%) in the CLARA arm and 46.5% (95% CI, 37% to 55%) in the HDAC arm. Overall, 110 patients (55 in each arm) received SCT in first remission. On the basis of a multivariable Cox-adjusted treatment × SCT interaction, the HR of CLARA over HDAC before or in absence of SCT was 0.65 (95% CI, 0.43 to 0.98; P = .041). In a sensitivity analysis, when patients who received SCT in first remission were censored at SCT time, 2-year RFS was 53.3% (95% CI, 39% to 66%) in the CLARA arm and 31.0% (95% CI, 19% to 43%) in the HDAC arm (HR, 0.63; 95% CI, 0.41 to 0.98; P = .043). Gain in RFS could be related to the lower cumulative incidence of relapse observed in the CLARA arm versus the HDAC arm (33.9% v 46.4% at 2 years, respectively; cause-specific HR, 0.61; 95% CI, 0.40 to 0.94; P = .025). CLARA cycles were associated with higher hematologic and nonhematologic toxicity than HDAC cycles. Conclusion These results suggest that CLARA might be considered as a new chemotherapy option in younger patients with AML in first remission.
Inhibiting Histone Deacetylase as a Means to Reverse Resistance to Angiogenesis Inhibitors: Phase I Study of Abexinostat Plus Pazopanib in Advanced Solid Tumor Malignancies
Authors: Aggarwal Rahul , Thomas Scott , Pawlowska Nela , Bartelink Imke , Grabowsky Jennifer , Jahan Thierry , Cripps Amy , Harb Armand , Leng Jim , Reinert Anne , Mastroserio Ilaria , Truong Thach-Giao , Ryan Charles J. , Munster Pamela N. 
Published: February 2017

Purpose This phase I trial evaluated epigenetic modulation of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor by using a histone deacetylase abexinostat in combination with pazopanib to enhance response and reverse resistance. Patients and Methods Pazopanib was administered once a day on days 1 to 28 and abexinostat was administered orally twice a day on days 1 to 5, 8 to 12, and 15 to 19 (schedule A) or on days 1 to 4, 8 to 11, and 15 to 18 (schedule B). Dose escalation (3 + 3 design) in all solid tumors was followed by dose expansion in renal cell carcinoma (RCC). Results Fifty-one patients with RCC (N = 22) were enrolled, including 30 (59%) with one or more lines of prior VEGF-targeting therapy. Five dose-limiting toxicities, including fatigue (n = 2), thrombocytopenia (n = 2), and elevated AST/ALT (n = 1), were observed with schedule A; one dose-limiting toxicity was observed (elevated AST/ALT) was observed with schedule B. Grade ≥ 3 related adverse events included fatigue (16%), thrombocytopenia (16%), and neutropenia (10%). The recommended phase II dose was established as abexinostat 45 mg/m2 twice a day administered per schedule B plus pazopanib 800 mg/d. Objective response rate was 21% overall and 27% in the RCC subset. Median duration of response was 9.1 months (1.2 to > 49 months). Eight patients (16%) had durable control of disease for > 12 months. Durable tumor regressions were observed in seven (70%) of 10 patients with pazopanib-refractory disease, including one patients with RCC with ongoing response > 3.5 years. Peripheral blood histone acetylation and HDAC2 gene expression were associated with durable response to treatment. Conclusion Abexinostat is well tolerated in combination with pazopanib, allowing prolonged exposure and promising durable responses in pazopanib- and other VEGF inhibitor-refractory tumors, which supports epigenetically mediated reversal of treatment resistance.
Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition
Authors: Lheureux Stephanie , Bruce Jeff P. , Burnier Julia V. , Karakasis Katherine , Shaw Patricia A. , Clarke Blaise A. , Yang S.Y. Cindy , Quevedo Rene , Li Tiantian , Dowar Mark , Bowering Valerie , Pugh Trevor J. , Oza Amit M. 
Published: February 2017

Purpose Durable and long-term responses to the poly (ADP-ribose) polymerase inhibitor olaparib are observed in patients without BRCA1/2 mutations. However, beyond BRCA1/2 mutations, there are no approved biomarkers for olaparib in high-grade serous ovarian cancer (HGSOC). To determine mechanisms of durable response and resistance to olaparib therapy, we performed an analysis of HGSOC tumors from three patients without germline BRCA1/2 mutations who experienced exceptional responses to olaparib. Patients and Methods We performed integrated exome, low-pass genome, and RNA sequence analysis of tumors at diagnosis and upon relapse from patients with platinum-sensitive HGSOC recurrence who were treated > 5 years with olaparib therapy as a single agent. Results We observed somatic disruption of BRCA1/2 in all three patients at diagnosis, followed by subsequent BRCA recovery upon progression by copy number gain and/or upregulation of the remaining functional allele in two patients. The third patient with ongoing response (> 7 years) had a tumor at diagnosis with biallelic somatic deletion and loss-of-function mutation, thereby lacking a functional allele for recovery of BRCA1 activity and indicating a potential cure. Conclusion Olaparib has durable benefit for patients with ovarian cancer beyond germline BRCA1/2 carriers. These data suggest that biallelic loss of BRCA1/2 in cancer cells may be a potential marker of long-term response to poly (ADP-ribose) polymerase inhibition and that restoration of homologous repair function may be a mechanism of disease resistance.
Accuracy and Thoroughness of Treatment Summaries Provided as Part of Survivorship Care Plans Prepared by Two Cancer Centers
Authors: Tevaarwerk Amye J. , Hocking William G. , Zeal Jamie L. , Gribble Mindy , Seaborne Lori , Buhr Kevin A. , Wisinski Kari B. , Burkard Mark E. , Wiegmann Douglas A. , Sesto Mary E. 
Published: February 2017

Purpose: Treatment summaries prepared as part of survivorship care planning should correctly and thoroughly report diagnosis and treatment information. Methods: As part of a clinical trial, summaries were prepared for patients with stage 0 to III breast cancer at two cancer centers. Summaries were prepared per the standard of care at each center via two methods: using the electronic health record (EHR) to create and facilitate autopopulation of content or using manual data entry into an external software program to create the summary. Each participant's clinical data were abstracted and cross-checked against each summary. Errors were defined as inaccurate information, and omissions were defined as missing information on the basis of the Institute of Medicine recommended elements. Results: One hundred twenty-one summaries were reviewed: 80 EHR based versus 41 software based. Twenty-four EHR-based summaries (30%) versus six software-based summaries (15%) contained one or more omissions. Omissions included failure to provide dates and specify all axillary surgeries for EHR-based summaries and failure to specify receptors for software-based summaries. Eight EHR-based summaries (10%) versus 19 software-based summaries (46%) contained one or more errors. Errors in EHR-based summaries were mostly discrepancies in dates, and errors in software-based summaries included incorrect stage, surgeries, chemotherapy, and receptors. Conclusion: A significant proportion of summaries contained at least one error or omission; some were potentially clinically significant. Mismatches between the clinical scenario and templates contributed to many of the errors and omissions. In an era of required care plan provision, quality measures should be considered and tracked to reduce rates, decrease inadvertent contributions from templates, and support audited data use.
Are They Married?
Authors: Ahmad Attiya 
Published: February 2017

AbstractIn recent years marriages among Muslims of different ethnonational backgrounds have developed in the Gulf region. While proponents of these “Muslim marriages” depict them as transnational alternatives to ethnonational forms of affinity and belonging, as I discuss in this article these marriages are shaped and constrained by the very ethnonational processes they are often juxtaposed against. Based on over eighteen months of ethnographic fieldwork conducted on foreign resident women’s Islamic halaqa in Kuwait, sites where “Muslim marriages” are deliberated and discussed, I argue that “Muslim marriages” constitute transnational forms that are not simply marked by the extension or diffusion of kinship networks, ethnonational forms, and religious piety movements across borders. They reveal how transnationalism constitutes a dynamic field in which kinship, ethnonationalism, and religious movements are invoked and reworked, configured and reconfigured together in often complex and contradictory ways.
Ethnographic and Literary Reflections on Miral Al-Tahawy’s The Tent
Authors: Seymour-Jorn Caroline 
Published: February 2017

Abstract
This article focuses on the Egyptian writer Miral al-Tahawy’s 1996 novel The Tent (al-Khibāʾ). This ethnographically informed novel sheds light on liminal, emotional, and imaginative aspects of social and personal life—those aspects that tend to be particularly challenging for the ethnographer to transmit in his or her writing about culture. I argue that we can read The Tent as ethnographically informed primarily because of the complex way in which al-Tahawy incorporates authentic poetry into the text and that this usage allows her to represent poetry as a culturally significant element of Bedouin women’s lives. I approach the novelist’s manner of writing about emotion and imaginativeness by attending to aesthetic processes themselves, which are often ignored by anthropologists looking at fiction.
Ο οικονομικός μετανάστης στην πολιτική ατζέντα: η δημόσια συγκρότηση του μεταναστευτικού ζητήματος στη μεταπολίτευση
Authors: Κουντούρη Φανή 
Published: February 2017

Στο άρθρο αυτό διερευνούμε τις μεταβολές τον πλαισίου ανάδειξης τον αλλοδαπού μετανάστη στην Ελλάδα κατά τη μεταπολιτευτική περίοδο. Πιο ειδικά, μελετούμε τον τρόπο με τον οποίο το μεταναστευτικό ζήτημα παρουσιάζεται ως πρόβλημα στο δημόσιο χώρο μέσα από το δημόσιο λόγο και την κοινωνική δράση, μέσα από τη δυναμική αλληλεπίδραση πολιτικών και κοινωνικών δρώντων που συγκρούονται δημόσια για τον ορισμό του. Η ανάλυση συνίσταται στην περιοδολόγηση της εξέλιξης του ορισμού του προβλήματος στη διάρκεια των τριάντα πέντε ετών της κοινωνικής του ύπαρξης: αν και το μεταναστευτικό ζήτημα τίθεται με τρόπο επιτακτικό μετά τη μαζική είσοδο μεταναστών από τις βαλκανικές χώρες, στις αρχές της δεκαετίας του 1990, οι προϋποθέσεις της κοινωνικής του συγκρότησης ανιχνεύονται ήδη στις δεκαετίες 1970 και 1980 και διαφοροποιούνται προς το τέλος της δεκαετίας του 1990. Οι αλλαγές στις κοινωνικές και πολιτικές συνθήκες μαρτυρούν τη μεταβολή των ηγεμονικών ορισμών του προβλήματος.
Η Ακροδεξιά στην Ανατολική Ευρώπη: Οι μεταμορφώσεις της, η σχέση της με τα κοινωνικά κινήματα και την Ευρωπαϊκή Ενοποίηση
Authors: Κόρδας Γεώργιος 
Published: February 2017

οι έρευνες των πολιτικών επιστημόνων τις τελευταίες δεκαετίες έχουν καταλήξει στην αναγνώριση τριών εξελικτικών κυμάτων της Άκρας Δεξιάς στη Δυτική Ευρώπη (von Beyme 1988: 8-10· Γεωργιάδου 2008: 87-88, 90). Ενώ τα κύματα αυτά διαμορϕώθηκαν σε ένα σχετικά μακρύ χρονικό διάστημα έξι δεκαετιών, στην Ανατολική Ευρώπη και στα Βαλκάνια το πολιτικό σκηνικό αναδείχθηκε μετά την πτώση του κομμουνισμού κατά έναν ριζικά διαϕορετικό τρόπο. πιο συγκεκριμένα η πτώση του Τείχους του Βερολίνου το 1989 συνέβαλε στη διάχυση του εθνικισμού στη νέα πολιτική πραγματικότητα. Επιπλέον η περίοδος αυτή χαρακτηρίζεται από μια ιδιότυπη οικονομική μετάβαση, όπου οι ‘κοινωνικά χαμένοι’ αποτελούν –δυνητικά- εκλογικό κοινό για την Ακροδεξιά.
Participantes heterogéneos en MOOCs y sus necesidades de aprendizaje adaptativo
Authors: Sein-echaluce Lacleta María Luisa , Lerís López Dolores , Hernández Miguel , Fidalgo-Blanco Ángel 
Published: February 2017

En numerosos estudios se señalan la masificación y la diversidad de perfiles de los participantes en los cursos masivos abiertos online (MOOC) como las principales causas de su baja tasa de finalización. Por otra parte, las metodologías de personalización del aprendizaje, junto a las tecnologías de la información, que permiten realizar técnicas de adaptatividad, figuran en informes internacionales como una forma eficaz de mejorar el aprendizaje. En este trabajo se explora la percepción de los participantes en MOOCs respecto a sus necesidades de adaptatividad en este tipo de cursos, así como su relación con distintos aspectos de los participantes, como sus perfiles (género, edad, ubicación geográfica y nivel académico), su experiencia previa o conocimiento sobre el tema del MOOC y su motivación para iniciar el MOOC. Se realiza el estudio a través de una encuesta cumplimentada por los participantes en el Campus MOOC de Innovación Educativa. Se concluye que la edad o género de los participantes no influye significativamente en su necesidad de técnicas adaptativas en un MOOC. Sin embargo, residir en un país de América Latina, tener una profesión de gestión o inscribirse en un MOOC con una motivación concreta son algunos de los factores que influyen en un mayor deseo de técnicas de adaptatividad en un MOOC. Los resultados obtenidos contribuirán a mejorar los diseños adaptativos de los MOOCs y son fácilmente transferibles a cualquier curso de formación en línea, en formación semipresencial o virtual.