bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ricinus communis L. (Castor bean), a potential multi-purpose environmental crop for improved and integrated phytoremediation
Authors: Kiran Boda Ravi , Prasad Majeti Narasimha Vara 
Published: May 2017

Abstract
Phytoremediation is a plant based environmental cleanup technology to contain (rendering less toxic), sequester and degrade contaminated susbtrates. As can be seen from data metrics, it is gaining cosiderable importance globally. Phytoremediation approach is being applied for cleanup of inorganic (potentially toxic metals), organic (persistent, emergent, poly-acromatic hydrocarbons and crude oil etc.) and co-contaminated (mixture of inorganic and organic) and/or polluted sites globally. Recently new approaches of utilizing abundantly available natural organic amendments have yielded significant results. Ricinus communis L. (Castor bean) is an important multipurpose crop viz., Agricultural, Energy, Environmental and Industrial crop. The current status of knowledge is abundant but scattered which need to be exploited for sustainable development. This review collates and evaluates all the scattered information and provides a critical view on the possible options for exploiting its potential as follows: 1. Origin and distribution, 2. Lead toxicity bioassays, 3. Progress in arbuscular mycorrhizal fungi-assisted phytoremediation, 4. Promising bioenergy crop that can be linked to pytoremediation, 5. A renewable source for many bioproducts with rich chemical diversity, 6. It is a good biomonitor and bioindicator of atmospheric pollution in urban areas, 7. Enhanced chelate aided remediation, 8. Its rhizospheric processes accelerate natural attenuation, 9. It is suitable for remediation of crude oil contaminated soil, 10. It is an ideal candidate for aided phytostabilization, 11. Castor bean is a wizard for phytoremediation and 12. Its use in combined phytoextraction and ecocatalysis. Further, the knowledge gaps and scope for future research on sustainable co-generation of value chain and value addition biobased products for sustainable circular economy and environmental security are described in this paper.
Epilobium angustifolium L.: A medicinal plant with therapeutic properties
Authors: Ostrovska Halyna , Oleshchuk Oleksandra , Vannini Samuele , Cataldi Samuela , Albi Elisabetta , Codini Michela , Moulas Anargyros , Marchyshyn Svitlana , Beccari Tommaso , Ceccarini Maria Rachele 
Published: May 2017

Abstract
Epilobium angustifolium L. is a medicinal plant belonging to the Onagraceae family, which includes more than 200 different species from all over the world. Traditional medicinal applications include treatment of prostate, gastrointestinal, menstrual disorders and recently it has been used for its analgesic and anti-inflammatory activity. In this investigation E. angustifolium was collected in Ternopil region of Ukraine. The obtained data demonstrated that E. angustifolium herb extract, rich in polyphenolic compounds such as flavonoids and tannins, display high antioxidant properties. In addition the potential anticancer activity has been investigated in vitro on human hepatocellular carcinoma cells (HepG2). Furthermore the cytotoxic and genotoxic effects of E. angustifolium have been investigated respectively by MTT and Comet assay. Results showed that at low concentration, up to 25 μg/mL, the cytotoxic effect was not observed. Increasing concentration from 50 to 75 μg/mL reduced significantly cell viability and induced an important DNA damage in hepatocellular carcinoma. These promising data were also confirmed with mitochondrial potential test. It is possible to conclude that E. angustifolium has beneficial properties in low concentration, in term of antioxidant activity, and it could be a potential antitumoral natural product if it will be used at high concentration
Clinical and economic issues complicating cost-effectiveness evaluation of orphan diseases
Authors: Nuijten Mark J.C. , Pronk Marja H. , Hutton John , Hasselt Peter van , Oosterwijk Cor , Rutten Frans F.H. 
Published: May 2017

Abstract
Cost-effectiveness evaluation of orphan medicinal products is confronted with a large confidence interval on the incremental cost-effectiveness ratios (ICERs), or extremely high ICERs and therefore rejection of products for uptake in the health insurance package (coverage) by health authorities in Europe. Examples from the United Kingdom (UK) and The Netherlands illustrated that straightforward application of the decision criteria might not always be possible, resulting in a large variety of coverage decisions that were neither transparent nor consistent with the criteria. This observation required more insight into what drives the high ICERs and what policies may support the appropriate use of orphan medicinal products. The most relevant clinical and economic issues that are perceived to complicate the cost-effectiveness evaluation of orphan medicinal products are discussed. Theoretically, two possible solutions are available: 1) circumvent or 2) keep the standard assessment criterion costeffectiveness. In analogy to the Europe Medicine Agency (EMA) registration approach of orphan medicinal products that are hampered by limitations in the clinical data at the time of registration, we suggest to stick to the use of standard uniform criteria, but that efforts should be directed at optimising the input to the cost-effectiveness evaluation. Subsequently potential policy approaches are developed.
Isolation and culture of endothelial cells from embryonic rat yolk sac
Authors: Ülger Harun , Karabulut Ahmet K. , Pratten Margaret K. 
Published: May 2017

Abstract
Yolk sac blood islands are the first morphologic evidence of hematopoietic development during mammalian embryogenesis, and visseral yolk sac mesoderm gives rise to the first embryonic blood cells within a rich endothelial network. Present study reports the isolation and culture of endothelial cells from 11.5 days old embryonic rat yolk sac. The embryos were dissected from 11.5 days pregnant Wistar rat (Rattus norvegicus) and the external yolk sac membrane and embryos were removed under aseptic condition. After washing three times with Calcium-Magnesium free Hank’s balanced salt solution (CMF-HBSS), the tissue was minced, and fragments were incubated in CMF-HBSS containing 2mg/ml Trypsin, 100mg/ml collagenase I and 40mg/ml DNAse at 37°C until the tissue was completely dispersed. The digestion effect was then neutralized by fetal bovine serum at 1:3 (v/v). The cell suspension was centrifuged at 1000 rpm for 10 min., the supernatants were discarded and the cell pellets resuspended in Dulbecco modified Eagle medium containing 15% fetal bovine serum, 1.25mg/ml amphotericin B, 25mg/ml gentamycin sulphate and 100mg/ml endothelial cell growth supplement. The resuspended cells were plated in two diverse 25cm2 culture flasks for overnight differential adherence at 37°C. The non-adherent cells were removed by gentle aspiration and adherent cells refed with fresh medium. The cells were transferred using 1ml of 0.2% Trypsin when cultures reached near-confluence. The cultured yolk sac endothelial cells had characteristic cobblestone appearence and positive immunofluorescent staining for von Willebrand Factor (vWF). Weibel-Palade bodies, the major ultrastructural marker for endothelium, were also detected in cultured cells by electron microscopy.
Localization of nuclear actin in nuclear lipid microdomains of liver and hepatoma cells: Possible involvement of sphingomyelin metabolism
Authors: Cataldi Samuela , Lazzarini Andrea , Codini Michela , Cascianelli Giacomo , Floridi Alessandro , Bartoccini Elisa , Ceccarini Maria Rachele , Ambesi-Impiombato Francesco Saverio , Beccari Tommaso , Curcio Francesco , Albi Elisabetta 
Published: May 2017

Abstract
Nuclear actin has been implicated in different nuclear functions. In this work, its localization in nuclear membrane, chromatin and nuclear lipid microdomains was investigated. The implication of sphingomyelin metabolism was studied. Nuclear membrane, chromatin and nuclear lipid microdomains were purified from hepatocyte nuclei and H35 human hepatoma cell nuclei. The presence of β-actin was analyzed with immunoblotting by using specific antibodies. Sphingomyelinase, sphingomyelin-synthase, and phosphatidylcholine-specific phospholipase C activities were assayed by using radioactivity sphingomyelin and phosphatidylcholine as substrate. The results showed that β-actin is localized in nuclear lipid microdomains and it increases in cancer cells. Evidence is provided to the difference of phosphatidylcholine and sphingomyelin metabolism in various subnuclear fractions of cancer cell nuclei compared with normal cells. Our findings show increase of sphingomyelin-synthase and inhibition of sphingomyelinase activity only in nuclear lipid microdomains. Nuclear lipid microdomains, constituted by phosphatidylcholine, sphingomyelin and cholesterol, play a role as platform for β-actin anchoring. Possible role of sphingomyelin metabolism in cancer cells is discussed.
Evaluation of probiotic potential of Bifidobacterium animalis subsp. lactis strains: an in vitro study
Authors: Sidarenka Anastasiya , Valentovich Leonid , Novik Galina 
Published: May 2017

Abstract
Probiotic potential of two bifidobacterial strains isolated from feces of healthy adults and identified as Bifidobacterium animalis subsp. lactis was evaluated using in vitro testing. The analyzed strains were able to ferment a broad spectrum of carbohydrates, produced bioactive exopolysaccharides, demonstrated high survival rate in model GIT conditions, under heat and oxidative stresses, inhibited growth of a wide range of pathogenic and opportunistic bacteria, and proved to be safe for biotechnological application. Based on the complex phenotypic characteristics tested, Bifidobacterium animalis subsp. lactis may be regarded as prospective probiotic cultures.
Biotechnological importance of sphagnum mosses
Authors: Shabeta Marina 
Published: May 2017

Abstract
Since Belarus is rich in sphagnum bogs it is extremely important to develop ways to use the resources of sphagnum mosses with a number of useful properties. Sphagnum is the only genus in the class Sphagnopsida and includes 36 Bryophyta species in Belarus. Sphagnum mosses, which are widespread in Belarus, have great potential for possible use in contaminated water purification from various hydrophilic and hydrophobic solvents and salt solutions, in light industry and agriculture (considering the need of their renewal).
Modal Sosial Untuk Kapasitas Community Governance (Studi Kasus Perempuan Pesisir Kelurahan Sulaa Kota Baubau)
Authors: Wijaya Andy Arya Maulana 
Published: May 2017

Penelitian ini betujuan untuk memberikan sudut pandangan yang lain tentang peran perempuan pesisir di Kelurahan Sulaa Kota Baubau. Bahwa peran perempuan pesisir tidak saja terbatas pada peran domestiknya saja, namun dengan pengelolaan modal sosial perempuan pesisir juga dapat berkontribusi dalam governance di tingkat lokal. Terdapat beberapa temuan dalam penelitian ini, yakni modal sosial perempuan pesisir yang nampak pada kelompok-kelompok perempuan pesisir dapat mengelola keberlanjutan organisasi perempuan pesisir pada tataran modal sosial bonding, bridging dan linking. Dalam hal modal sosial bonding ditunjukkan dengan Kepemimpinan organisasi kelompok perempuan yang cukup efektif dalam mengelola organisasi, adanya kesadaran gerakan menabung, dan berlangsungnya proses berbagi informasi dan pengetahuan; untuk modal sosial bridging Ditunjukkan dalam bentuk jaringan kerjasama dengan kelompok lain, dengan jaringan ini kemudian kelompok perempuan pesisir memproduksi berbagai inovasi usaha dan berbagai pengetahuan umum lainnya; serta modal sosial linking Ditunjukkan pada adanya partisipasi kelompok perempuan pesisir baik dalam pengembangan kelompok, pelatihan, pemasaran produk usaha mereka, serta pemerolehan bantuan dari Pemda. Namun, perubahan lingkungan, kemampuan sumberdaya serta tuntutan yang terus berubah memerlukan adanya adaptasi terus menerus terhadap kapasitas kelompok perempuan pesisir, oleh karena itu dalam persoalan dukungan pemerintah daerah Kota Baubau tetap diperlukan.
Analisis Indeks Kepuasan Masyarakat Badan Pelayanan Perizinan Terpadu Kota Tegal
Authors: Zainudin Arif 
Published: May 2017

Pelayanan publik adalah merupakan kegiatan atau rangkaian kegiatan dalam rangka pemenuhan kebutuhan pelayanan sesuai dengan peraturan perundang-undangan bagi setiap warga negara dan penduduk atas barang, jasa, dan pelayanan administratif yang disediakan oleh penyelenggaraan pelayanan publik. Sebagaimana seperti yang diamanahkan UU 25 tahun 2009 tentang pelayanan publik, seluruh instansi pemerintah yang memberikan pelayanan wajib memberikan pelayanan yang optimal dan berkualitas. Kualitas pelayanan idealnya selalu dikaji setiap berkala, sehingga pelayanan dapat terkontrol. Penelitian ini bertujuan untuk mencari indeks kepuasan masyarakat Badan Pelayanan Perijinan Terpadu Kota Tegal pada tahun 2014, dan ingin mengetahui harapan masyarakat mengenai pelayanan yang diberikan oleh Badan Pelayanan Perijinan Terpadu Kota Tegal.Dalam menganalisis IKM Badan Pelayanan Perizinan Terpadu Kota Tegal peneliti menggunakan indikator penelitian yang tercantum dalam Permenpan No. 16 Tahun 2014 tentang Pedoman Survei Kepuasan Masyarakat Terhadap Penyelenggaraan Pelayanan Publik. Berdasarkan hasil kuesioner dan interview terhadap responden sejumlah 100 orang pengguna jasa layanan BP2T Kota Tegal diperoleh nilai IKM sebesar 80,08 % yang dikonversikan kedalam mutu pelayanan tergolong kinerja pelayanan “baik” atau “B” hasil tersebut mengalami peningkatan dari tahun sebelumnya sebesar 2%. Kemudian untuk mengetahui gap antara harapan dan kenyataan pelayanan, peneliti menggunakan analisis diagram kartesius atau Importance Performance Analysis dengan hasil bahwa unsur yang tergolong dalam kuadran A yakni Prioritas Utama untuk dioptimalkan meliputi prosedur pelayanan, dan waktu pelayanan, dan yang tergolong dalam kuadran B yakni unsur yang harus dipertahankan meliputi persyaratan pelayanan, biaya/tarif, produk spesifikasi, kompetensi pelaksana, perilaku pelaksana, maklumat pelayanan, penanganan pengaduan saran, dan masukan pelayanan.Melihat hasil penelitian yang telah dilakukan peneliti memberikan rekomendasi perbaikan proses pelayanan dalam unsur prosedur dan waktu pelayanan mendapatkan perhatian khusus untuk reformasi proses bisnis pelayanan di BP2T Kota Tegal.
PENGARUH SUHU DAN PENAMBAHAN NUTRISI PADA PROSES FERMENTASI UNTUK PEMBUATAN BIOETHANOL DARI SABUT KELAPA
Authors: Anggorowati Dwi Ana , Purwati Purwati , P Sulis Dwi 
Published: May 2017

Pada saat ini, bioethanol diperhitungkan sebagai pilihan yang lebih baik daripada bahan bakar fosil karena dapat mengurangi ketergantungan pada minyak mentah. Bioetanol juga menjanjikan pembakaran lebih bersih yang mendorong ke arah lingkungan yang lebih sehat karena karbon yang dihasilkan dari proses pembakaran netral dan yang terpenting bebas dari sulfur. Bahan- bahan yang mungkin digunakan sebagai penghasil bioetanol biasanya mengandung karbohidrat, seperti pati sagu, jagung dan bongkolnya, singkong, rumput laut dan limbahnya.Dari sekian banyak bahan yang tersedia di alam selain bahan berpati, bahan lignoselulosa merupakan substrat terbanyak yang belum digunakan secara maksimal.Salah satu bahan yang mengandung lignoselulosa adalah buah kelapa, terutama bagian sabut kelapa. Sabut kelapa merupakan bagian yang cukup besar dari buah kelapa yaitu 35% dari berat keseluruhan buah. Tujuan Penelitian ini adalah untuk mengetahui pengaruh suhu terbaik pada proses fermentasi, dan mengetahui pengaruh penambahan nutrisi (NH4)2HPO4 terbaik pada proses fermentasi.Variabel penelitian ini antara lain : Suhu fermentasi yaitu 26, 29, 31, 33 dan 35 oC dan beratnutrisi (NH4)2HPO4 yaitu 5, 7, 9, 11 dan 13 g. Dari hasil penelitian yang telah dilakukan, hasil terbaik didapatkan pada kondisi fermentasi pada suhu 29oC menghasilkan kadar etanol sebesar 0,46790%. Serta penambahan nutrisi (NH4)2HPO4 pada proses fermentasi sebanyak 7 g menghasilkan kadar etanol sebesar 0,46790%. Kata kunci : Bioetanol, Sabut Kelapa,Saccharomyces Cerevisea
PENGGUNAAN LIMBAH PRODUKSI BATU PECAH DI KABUPATEN SUMENEP SEBAGAI BAHAN PENGGANTI PASIR PADA CAMPURAN BATA BETON (PAVING BLOCK)
Authors: Deshariyanto Dwi , Harun Mohammad 
Published: May 2017

Ketersediaan limbah hasil produksi batu pecahsecara masinal dan terbatasnya sumber daya alam yang di Kabupaten Sumenep khususnya tersedianya pasir hitam yang digunakan dalam campuran bata beton, maka perlu diteliti penggunaan limbah produksi batu pecah secara masinal untuk digunakan sebagai bahan penganti pasir pada campuran bata beton (paving block).Metode yang digunakan dalam penelitian ini adalahmelakukan percobaan di laboratorium. Hasil pengujian bata beton dianalisis menggunakan uji F dan uji regresi serta menganalisis bata beton berdasarkan SNI 03 – 0691– 1996 tentang bata beton.Hasil perhitungan uji variance maupun uji regresi menujukan bahwa ada perbedaan kuat tekan, ada perbedaan penyerapan air dan tidak ada perbedaan ketahanan aus antara perlakuan dalam menambahkan limbah batu pecah sebagai bahan pengisi (filler) pada campuran paving block.. Kualitas paving block yang digunakan sebagai benda uji mempunyai sifat tampak dari semua perlakuan mempunyai permukaan yang rata, tidak terdapat retak – retak dan cacat, bagian sudut dan rusuknya ada sebagian yang mudah dirapihkan dengan menggunakan jari tangan. ukuran semua perlakuan mempunyai tebal rata – rata 6,08 cm, sehingga paving block yang digunakan sebagai benda uji penelitian memenuhi syarat mutu paving block. Persyaratan sifat fisika paving block menurut SNI 03-0691-1996 tidak memenuhi persyaratan untuk ketahanan aus dan penyerapan air. Kata kunci : Limbah, bahan pengganti, bata beton
PENGGUNAAN METODE STAD UNTUK MENINGKATKAN PENGUASAAN READING COMPREHESION DAN PENINGKATAN MOTIVASI BELAJAR
Authors: Andiriyanto Achmad 
Published: May 2017

Metode pembelajaran kooperatif bukan suatu yang hal baru. Metode ini sudah bertahun-tahun digunakan para pendidik dalam berbagai bidang studi dan dalam berbagai jenjang pendidikan mulai dari taman kanak-kanak sampai perguruan tinggi. Penggunaan metode kooperatif diharapkan dapat memberikan variasi pembelajaran yang effektif dan dapat memberikan motivasi kepada siswa untuk saling membantu dan mendukung satu sama lain dalam pembelajaran bahasa inggris. Tujuan dari penelitian ini untuk mengetahui pengaruh penggunaan metode STAD sebagai metode pembelajaran terutama dalam aspek pengembangan reading comprehension dan mengetahui tingkat motivasi siswa dengan menggunakan metode STAD. Penelitian ini merupakan penelitian dengan desain penelitian tindakan kelas yang dilaksanakan dengan rancangan melalui empat tahap yaitu; (1) perencanaan, (2) pelaksanaan tindakan, (3) Observasi dan (4) refleksi serta menngunakan pre-test dan pos-test. Hasil analisis menunjukkan bahwa penggunaan metode Student Team – Achievement Division (STAD) berhasil mewujudkan tujuan penelitian. Keberhasilan dinyatakan atas dasar kesimpulan bahwa penggunaan metode STAD memberikan dampak intruksional berupa; peningkatan kemampuan reading comprehension hal ini dapat diketahui dengan adanya peningkatan aktifitas belajar siswa dalam kegiatan kelas. Antara lain keaktifan bertanya dan menjawab pertanyaan guru, mengungkapkan pendapat serta bekerjasama dalam berdiskusi dan presentasi, serta ditunjukkan dengan hasil ketuntasan belajar siswa yang pada awalnya 30%, pos-test pada siklus I yaitu sebesar 63% dan pos-test pada siklus II sebesar 95% hal ini bearti antara siklus I dan II mengalami peningkatan sebesar 32%. Hal ini menunjukkan indikator keberhasilan penelitian ini sudah terpenuhi dan penggunaan metode STAD dapat meningkatkan hasil belajar reading comprehension siswa.
KMOS3D Reveals Low-level Star Formation Activity in Massive Quiescent Galaxies at 0.7 < z < 2.7∗
Authors: Belli Sirio , Genzel Reinhard , Förster Schreiber Natascha M. , Wisnioski Emily , Wilman David J. , Wuyts Stijn , Mendel J. Trevor , Beifiori Alessandra , Bender Ralf , Brammer Gabriel B. , Burkert Andreas , Chan Jeffrey , Davies Rebecca L. , Davies Ric , Fabricius Maximilian , Fossati Matteo , Galametz Audrey , Lang Philipp , Lutz Dieter , Momcheva Ivelina G. , Nelson Erica J. , Saglia Roberto P. , Tacconi Linda J. , Tadaki Ken-ichi , Übler Hannah , van Dokkum Pieter 
Published: May 2017

Abstract
We explore the Hα emission in the massive quiescent galaxies observed by the KMOS3D survey at 0.7 < z < 2.7. The Hα line is robustly detected in 20 out of 120 UVJ-selected quiescent galaxies, and we classify the emission mechanism using the Hα line width and the [N ii]/Hα line ratio. We find that AGNs are likely to be responsible for the line emission in more than half of the cases. We also find robust evidence for star formation activity in nine quiescent galaxies, which we explore in detail. The Hα kinematics reveal rotating disks in five of the nine galaxies. The dust-corrected Hα star formation rates are low (0.2–7 M
⊙ yr−1), and place these systems significantly below the main sequence. The 24 μm-based, infrared luminosities, instead, overestimate the star formation rates. These galaxies present a lower gas-phase metallicity compared to star-forming objects with similar stellar mass, and many of them have close companions. We therefore conclude that the low-level star formation activity in these nine quiescent galaxies is likely to be fueled by inflowing gas or minor mergers, and could be a sign of rejuvenation events.
Explosive Chromospheric Evaporation Driven by Nonthermal Electrons around One Footpoint of a Solar Flare Loop
Authors: Li D. , Ning Z. J. , Huang Y. , Zhang Q. M. 
Published: May 2017

Abstract
We explore the temporal relationship between microwave/hard X-ray (HXR) emission and Doppler velocity during the impulsive phase of a solar flare on 2014 October 27 (SOL2014-10-27) that displays a pulse on the light curves in the microwave (34 GHz) and HXR (25–50 keV) bands before the flare maximum. Imaging observation shows that this pulse mainly comes from one footpoint of a solar flare loop. The slit of the Interface Region Imaging Spectrograph (IRIS) stays at this footpoint during this solar flare. The Doppler velocities of Fe xxi 1354.09 Å and Si iv 1402.77 Å are extracted from the Gaussian fitting method. We find that the hot line of Fe xxi 1354.09 Å (log T ∼ 7.05) in the corona exhibits blueshift, while the cool line of Si iv 1402.77 Å (log T ∼ 4.8) in the transition region exhibits redshift, indicating explosive chromospheric evaporation. Evaporative upflows along the flare loop are also observed in the AIA 131 Å image. To our knowledge, this is the first report of chromospheric evaporation evidence from both spectral and imaging observations in the same flare. Both microwave and HXR pulses are well correlated with the Doppler velocities, suggesting that the chromospheric evaporation is driven by nonthermal electrons around this footpoint of a solar flare loop.