bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nephrotoxicity Associated with Concomitant Use of Ledipasvir‐Sofosbuvir and Tenofovir in a Patient with Hepatitis C Virus and Human Immunodeficiency Virus Coinfection
Authors: Bunnell Kristen L. , Vibhakar Sonia , Glowacki Robert C. , Gallagher Maureen A. , Osei Albert M. , Huhn Gregory 
Published: July 2016

Direct‐acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV) infection, with superior efficacy and safety compared to interferon‐based therapies. Despite these improvements, drug interactions with DAAs exist and may be clinically relevant in human immunodeficiency virus (HIV)‐coinfected patients. We present a case of nephrotoxicity associated with concomitant use of tenofovir disoproxil fumarate (TDF) and ledipasvir‐sofosbuvir (LDV‐SOF). A 56‐year‐old woman with HIV infection who had been taking efavirenz/tenofovir/emtricitabine (EFV/TDF/FTC) for 6 years developed acute kidney injury 8 weeks after initiating LDV‐SOF for the treatment of HCV infection. Her serum creatinine concentration peaked at 10 mg/dL, compared with her baseline concentration of 0.9–1 mg/dL. Kidney biopsy revealed acute tubular necrosis and acute interstitial nephritis. Both LDV‐SOF and TDF were discontinued, and the patient's serum creatinine concentration decreased to 1.3 mg/dL over the following 6 weeks. We postulate that this adverse drug reaction may have been secondary to the known interaction between ledipasvir and TDF, which results in increased TDF exposure. Despite knowledge of this interaction, LDV‐SOF is commonly prescribed in patients with HIV‐HCV coinfection, as patients who received LDV‐SOF– and TDF‐containing regimens in trials have not demonstrated adverse clinical consequences related to this interaction. This case highlights the rare but potentially serious nephrotoxicity that can result from TDF toxicity and serves as a reminder to clinicians to implement close renal function monitoring in patients receiving both LDV‐SOF and TDF. Clinicians prescribing LDV‐SOF to HCV‐HIV–coinfected patients receiving TDF should be cautious about use with concomitant nephrotoxic medications and monitor markers of tubular dysfunction, including urinary phosphorus excretion, and renal injury at baseline and week 4 of therapy. Tenofovir alafenamide and alternative DAAs may also have a role in the management of patients at high risk for renal adverse effects from TDF.
II‐VI Compounds and Related Materials
Authors: Testelin Christophe , Galtier Pierre , Sallet Vincent 
Published: July 2016

AbstractThe 17th International Conference on II–VI Compounds and Related Materials was held at the Campus des Cordeliers, in the historical center of Paris, France, from September 13th to 18th.II–VI 2015 has followed the path of a suc‐cessful series of biennial conferences which started in Durham (UK) in 1983. Recent conferences were or‐ganized in Niagara Falls (USA, 2003), Warsaw (Po‐land, 2005), Jeju (Korea, 2007), Saint Petersburg (Russia, 2009), Mayan (Mexico, 2011), and Na‐gahama (Japan, 2013).The II–VI conference aims at providing an international forum for scientists, students and indus‐try representatives, facilitating the exchange of new ideas and establishing fructuous scientific contacts. The ambition is to report the newest developments in basic and applied research on II–VI and re‐lated compounds such as oxides and chalcopyrite semiconductors. The topics cover also novel synthe‐sis techniques, new physical properties and innova‐tive device development. Let us note that for this last edition, the scope has been extended to Related Mate‐rials like photovoltaic materials and novel 2D sys‐tems (dichalcogenides and topological insulators).Gathering 240 participants, II–VI Paris 2015 has fulfilled its mission, with a scientific pro‐gram presenting three plenary review lectures, 15 in‐vited talks, 64 contributed talks and about 200 con‐tributed poster presentations. A special session has been devoted to the memory of Prof. Fritz Henneber‐ger from Humboldt University, Berlin.Following the conference, this issue of physica status solidi offers a variety of basic and applied studies on optical, electrical and mag‐netic properties of II–VI compounds, related materials and devices. Achievements in practical ap‐plications of II–VI compounds will be found in infrared, visible and UV range detectors, optoelec‐tronic devices, photovoltaics. The proceedings edition also emphasizes new trends and pioneering directions, towards original related materials and devices. A total of 78 articles are published in pss  (b) (11), pss RRL (1) and pss  (c) (66). We wish that all participants would appreciate to redis‐cover and thoroughly read some of the nice results presented in Paris.We thank all contributors and reviewers who made the edition of II–VI Paris Proceedings a great success and hope the conference as well as the unique atmosphere of Paris will remain in your heart and memory!
Synthesis and Spectroscopic Properties of PdII and PtII Complexes with Monosulfide and Monoselenide Bis(phosphanyl)amine Ligands
Authors: Al‐Masri Harbi Tomah , Moussa Ziad 
Published: July 2016

Abstract Oxidation of N,N‐bis(diphenylphosphanyl)naphthalen‐1‐amine (1) with elemental sulfur or gray selenium (1:1 molar ratio) gave the corresponding monosulfide and monoselenide bis(phosphanyl)amine ligands C10H7‐1‐N(P(E)Ph2)(PPh2) [E = S (2), Se (3)], respectively. Reactions of 2 and 3 with MCl2(cod) (M = Pd, Pt) afforded [MCl2{2‐κ2P,S}] [M = Pd(4), Pt(5)] and [MCl2{3‐κ2P,Se}] [M = Pd(6), Pt(7)], respectively. In contrast, reactions of the same ligands with NiCl2(PPh3)2 resulted in deselenization and desulfurization, producing complex 8 with the formula [NiCl2{1‐κ2P,P}]. Ligands 2 and 3, as well as their complexes 4–7 and 8 were identified and characterized by multinuclear NMR (1H, 13C, 31P, and 77Se NMR) spectroscopy, elemental analysis, and IR spectroscopy. Additionally, the molecular structure of 8 was obtained.
Deterioration Kinetics of Crude Palm Oil, Canola Oil and Blend During Repeated Deep‐Fat Frying
Authors: Mba Ogan I. , Dumont Marie‐Josée , Ngadi Michael 
Published: July 2016

AbstractThe oxidation of vegetable oils is generally treated as an apparent first order kinetic reaction. This study investigated the deterioration of crude palm oil (CPO), refined canola oil (RCO) and their blend (CPO:RCO 1:1 w/w) during 20 h of successive deep‐fat frying at 170, 180 and 190 °C. Kinetics of changes in oil quality indices, namely, free fatty acid (FFA), peroxide value (PV), anisidine value (p‐AV), total polar compounds (TPC) and color index (CI) were monitored. The results showed that FFA and PV accumulation followed the kinetic first order model, while p‐AV, TPC and CI followed the kinetic zero order model. The concentration and deterioration rate constants k, increased with increasing temperatures. This effect of temperature was modeled by the Arrhenius equation. The results showed that PV had the least activation energies Ea (kJ/mol) values of 5.4 ± 1 (RCO), 6.6 ± 0.7 (CPO) and 11.4 ± 1 (blend). The highest Ea requirement was exhibited by FFA with a range of 31.7 ± 3–76.5 ± 7 kJ/mol for the three oils. The overall Ea values showed that the stability of the blend was superior and not just intermediate of CPO and RCO. The correlation of the other oil quality indices with TPC indicated a positive linear correlation. The p‐AV displayed the strongest correlation, with mean correlation coefficient rs of 0.998 ± 0.00, 0.994 ± 0.00 and 0.999 ± 0.00 for CPO, RCO and blend, respectively.
Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness
Authors: Staubo Sara C. , Aakre Jeremiah A. , Vemuri Prashanthi , Syrjanen Jeremy A. , Mielke Michelle M. , Geda Yonas E. , Kremers Walter K. , Machulda Mary M. , Knopman David S. , Petersen Ronald C. , Jack Clifford R. , Roberts Rosebud O. 
Published: July 2016

AbstractIntroductionThe Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers.MethodsAmong 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar).ResultsHigher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness.DiscussionIn this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross‐sectional findings require validation in prospective studies.
Building a Knowledge to Action Program in Stroke Rehabilitation
Authors: Janzen Shannon , McIntyre Amanda , Richardson Marina , Britt Eileen , Teasell Robert 
Published: July 2016

AbstractThe knowledge to action (KTA) process proposed by Graham et al (2006) is a framework to facilitate the development and application of research evidence into clinical practice. The KTA process consists of the knowledge creation cycle and the action cycle. The Evidence Based Review of Stroke Rehabilitation is a foundational part of the knowledge creation cycle and has helped guide the development of best practice recommendations in stroke. The Rehabilitation Knowledge to Action Project is an audit-feedback process for the clinical implementation of best practice guidelines, which follows the action cycle. The objective of this review was to: (1) contextualize the Evidence Based Review of Stroke Rehabilitation and Rehabilitation Knowledge to Action Project within the KTA model and (2) show how this process led to improved evidence-based practice in stroke rehabilitation. Through this process, a single centre was able to change clinical practice and promote a culture that supports the use of evidence-based practices in stroke rehabilitation.
Needs–supplies fit and behavioral outcomes: The mediating role of organizational identification
Authors: Travaglianti Fabrice , Babic Audrey , Pepermans Roland , Hansez Isabelle 
Published: July 2016

AbstractWhile it is well known that person–organization fit is an important antecedent of behavioral outcomes, little is known about needs–supplies fit in this relationship. In this way, we first want to extend our knowledge about defining and assessing work-related needs derived from employment quality indicators as the basis for needs–supplies fit. Second, following the Cognitive and Affective Personality System theory, we test the mediating role of organizational identification to better understand how needs–supplies fit is related to task performance and organizational citizenship behaviors. Data were collected in two companies: sample 1 (N=525) and sample 2 (N=525). Results show (a) that a specific needs–supplies fit perception (i.e., based on 12 work-related needs derived from employment quality indicators) is positively related to a global needs–supplies fit perception (i.e., based on an overall job perception), suggesting that needs–supplies fit may be a multidimensional concept and (b) the full mediating role of organizational identification in the relationship between needs–supplies fit and performance measures.
EFFECTS OF SOIL CHARACTERISTICS AND DATE PALM MORPHOLOGICAL DIVERSITY ON NUTRITIONAL COMPOSITION OF PAKISTANI DATES
Authors: FATIMA GHAYOOR , WIEHLE MARTIN , KHAN IQRAR AHMAD , KHAN ASIF ALI , BUERKERT ANDREAS 
Published: July 2016

SUMMARYThe use of date palm (Phoenix dactyliferaL.) has been closely connected with the survival of people in arid areas given their fruits´ high concentration of energy, fibre, minerals, vitamins and 16 amino acids. The arid climate and sandy or clayey loam soils in many parts of Pakistan are ideal for the cultivation of date palm, which contributes to feeding the country's rapidly growing population. To fill knowledge gaps on the effects of cultivar diversity and cultivation sites on the nutritional properties of dates, the present project studied dates and related physical and chemical soil properties across six districts in four provinces of Pakistan: Jhang, Muzaffargarh and Bahawalpur in Punjab; Dera Ismail Khan (D. I. Khan) in Khyber Pakhtunkhwa (KPK); Khairpur in Sindh and Panjgur in Baluchistan. To this end, during 2012–2013, a total of 170 households (HHs) were selected using a snowball sampling approach. Thirty-nine different date palm cultivars with diverse nutritional properties are grown in the study area. In these total soluble solids (TSS) were highest in Muzawati and Koharba cultivars, while cultivars and site conditions significantly affected TSS, minerals (calcium and magnesium), acidity, and firmness of dates. Concentration of CaCO3and bulk density (BD) of soils varied widely, while hydraulic conductivity (HC) was similar across sites (p= 0.128). Mean soil pH was highest in Panjgur (8.3) and lowest in Muzaffargarh (7.6), soil organic matter content was highest in Jhang (0.8%) and lowest in D. I. Khan (0.6%) and plant available phosphorous (P) was highest in Muzaffargarh (7.8 mg kg−1) and lowest in Panjgur (6.0 mg kg−1). As indicated by correlation analysis BD and cation exchange capacity of soils seemed to affect TSS, whereas concentration of CaCO3and available P were correlated with calcium concentration of dates. HC and electrical conductivity, however, seemed to have little effect on dates´ nutritional properties.
Notes on selected Cretaceous echinoids from south-central Sakhalin, Far East Russia
Authors: Jagt J.W.M. , Jagt-Yazykova E.A. , Zonova T.D. 
Published: July 2016

AbstractFrom Albian, Santonian and Campanian strata in south-central Sakhalin, four echinoid taxa are described, illustrated and discussed. In Far East Russia, echinoids are rare constituents amongst mid- and Late Cretaceous macrofaunal assemblages in which inoceramid and non-inoceramid bivalves, plus heteromorph and non-heteromorph ammonites predominate. The sole regular species in the present lot is represented by an incomplete external mould of a primary spine of a rhabdocidarid,Polycidaris(?) sp., from the lower Campanian. Irregular taxa include a fragmentary, specifically indeterminate ‘pygurid’,Echinopygus(?) sp., of late Albian age, as well as two spatangoids. One of these, a toxasterid of late Campanian age, is assigned toNiponastercf.hokkaidensis(LambertinLambert & Thiéry, 1924). The other is a new hemiasterid with a semi-ethmophract apical disc, a peripetalous fasciole with diffuse boundaries (parafasciole) and posterior petals that are near-equal in length to anterior ones, from lowermost Campanian strata. For this, the namePalhemiaster natalyaen. sp. is introduced. Comparisons with coeval echinoid faunas from nearby Hokkaido (northern Japan) are hampered by the generally poor preservation of the latter. However, with the exception ofNiponastercf.hokkaidensis, none of the forms recorded in the present paper appears to be represented in those Japanese assemblages.
Variations in the morphology of porosity in the Boom Clay Formation: insights from 2D high resolution BIB-SEM imaging and Mercury injection Porosimetry
Authors: Hemes S. , Desbois G. , Urai J.L. , De Craen M. , Honty M. 
Published: July 2016

AbstractBoom Clay is considered as one of the potential host rocks for the disposal of high level and/or long lived radioactive waste in a geological formation in Belgium (Mol study site, Mol-1 borehole) and the Netherlands. The direct characterisation of the pore space is essential to help understand the transport properties of radionuclides in argillaceous materials.This contribution aims to characterise and compare the morphology of the pore space in different Boom Clay samples, representing end-members with regard to mineralogy (i.e. clay content) and grain-size distribution of this formation. Broad ion beam (BIB) cross-sectioning is combined with SEM imaging of porosity and Mercury injection Porosimetry (MIP) to characterise the variability of the pore space in Boom Clay at the nm- to μm-scale within representative 2D areas and to relate microstructural observations to fluid flow properties of the bulk sample material. Segmented pores in 2D BIB surfaces are classified according to the mineralogy, generating representative datasets of up to 100,000 pores per cross-section.Results show total SEM-resolved porosities of 10-20% and different characteristic mineral phase internal pore morphologies and intra-phase porosities.Most of the nano-porosity resides in the clay matrix. In addition, in the silt-rich samples, larger inter-aggregate pores contribute to a major part of the resolved porosity. Pore-size distributions within the clay matrix suggest power-law behaviour of pore areas with exponents between 1.56-1.74. Mercury injection Porosimetry, with access to pore-throat diameters down to 3.6 nm, shows total interconnected porosities between 27-35 Vol.-%, and the observed hysteresis in the MIP intrusion vs. extrusion curves suggests relatively high pore-body to pore-throat ratios in Boom Clay. The difference between BIB-SEM visible and MIP measured porosities is explained by the resolution limit of the BIB-SEM method, as well as the limited size of the BIB-polished cross-section areas analysed. Compilation of the results provides a conceptual model of the pore network in fine- and coarse-grained samples of Boom Clay, where different mineral phases show characteristic internal porosities and pore morphologies and the overall pore space can be modelled based on the distribution of these mineral phases, as well as the grain-size distribution of the samples investigated.
The role of a proto-Schelde River in the genesis of the southwestern Netherlands, inferred from the Quaternary successions and fossils in Moriaanshoofd Borehole (Zeeland, the Netherlands)
Authors: Slupik A.A. , Wesselingh F.P. , Mayhew D.F. , Janse A.C. , Dieleman F.E. , van Strydonck M. , Kiden P. , Burger A.W. , Reumer J.W.F. 
Published: July 2016

AbstractWe investigated the Quaternary lithological succession and faunas in a borehole near Moriaanshoofd (Province of Zeeland, SW Netherlands), in order to improve our understanding of the depositional context of classical Gelasian mammal faunas from the region. The fossils mostly derive from the base of a fossil-rich interval between 31 m and 36.5 m below the surface, that was initially interpreted as a Middle or Late Pleistocene interglacial marine unit, but turned out to be a Late Quaternary fluvial unit with large amounts of reworked fossils and sediments. Eocene mollusc taxa pinpoint Flanders (Belgium) as the source region for this river. Within the base of this paleo-Schelde River fossil material of various stratigraphic provenance became incorporated.
Exploration in the Netherlands, 1987-2012
Authors: Kombrink H. , ten Veen J.H. , Geluk M.C. 
Published: July 2016

AbstractFollowing a time of expansion of the oil industry, the period 1987-2012 and especially the second half of it reflects a diversification of exploration activities in the Netherlands. In addition to the ongoing discovery of classical hydrocarbon reservoirs, successful attempts have been made to explore deep geothermal energy. Shale gas and Coal Bed Methane received interest in the Netherlands too but so far no wells have been drilled in order to test the potential. Storage of gas and liquids has been introduced and salt mining more or less continued without many changes. In terms of drilling activity, the last 25 years show a decreasing trend and the discovered volumes are smaller. Testing of new play concepts was either successful (shallow gas) or not (Dinantian) and sometimes an unexpected discovery was made (Triassic Fat Sands). New techniques proved older fields to be exploitable again, e.g. redevelopment of the Schoonebeek Field. Therefore, despite a decline in number of wells drilled and reserves added, the diversification of use of the subsurface will guarantee ongoing exploration.
Thin- and thick-skinned salt tectonics in the Netherlands; a quantitative approach
Authors: ten Veen J.H. , van Gessel S.F. , den Dulk M. 
Published: July 2016

AbstractThe Zechstein salt in the Dutch part of the North Sea Basin played a key role in the generation of successful petroleum plays. This is not only because of its sealing capacity, but also because the salt occurs in structures that provide lateral and vertical traps. The structural styles of areas with thick salt and those with none- or thin salt are completely different during phases of extensional or compressional tectonics. This indicates that, indirectly, the depositional thickness of the main Zechstein salt is essential in regulating the loci of the Dutch petroleum systems. In this paper we aim at quantifying current ideas on the relationship between 1) depositional salt thicknesses; 2) structural style of the main structural elements identified in the Dutch subsurface; 3) timing of deformation; and 4) thickness of the overburden. By finalisation of TNO's subsurface mapping program (see Kombrink et al., this issue), several data products are available that allow evaluation of these relationships. The depositional thickness of the salt was estimated using iterative smoothing of the present day thickness, the results of which account both for regional thickness variations and volume preservation (99%). Fault-distribution analysis shows that faults are only able to penetrate salt with a depositional thickness of <300 m, a transition that demarcates the division between thin- and thick-skinned salt tectonics. In the southern offshore where the salt is thin or absent, the overburden shows the same fault pattern throughout the stratigraphic sequence. In the northern realm, where salt is thicker than 300 m, the salt layer acted as decollement and sub- and supra salt strain are dissimilar. A strong genetic and temporal relationship exists between periods of regional tectonism, halokinetic intensity and thickness distribution of the Zechstein overburden. This relationship is further proven by burial history analysis across two selected profiles in the northern offshore. The analysis focuses on the vertical distribution of the salt by taking into account the depositional and erosional history of the salt overburden, without a-priori defined periods of salt flow. The results corroborate the notion that platforms and highs experienced less extension during the major phases of Jurassic rifting and further suggest that the absence of a thick Jurassic overburden precludes major salt flow during this tectonic phase. Main salt flow was triggered during the Sub-Hercynian and later phases of compression resulting in salt pillow geometries. In the basinal areas, where the Jurassic succession is thickest, salt diapirs and walls formed that are almost exclusively linked to major subsalt faults. Main salt flow occurred during Late Kimmerian rifting, whereas some minor structuration occurred during Sub-Hercynian inversion.