bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attenuated processing of vowels in the left hemisphere predicts speech-in-noise perception deficit in children with autism
Authors: Fadeev Kirill A. , Reyes Ilacai V. Romero , Goiaeva Dzerassa E. , Obukhova Tatiana S. , Ovsiannikova Tatiana M. , Prokofyev Andrey O. , Rytikova Anna M. , Novikov Artem Y. , Kozunov Vladimir V. , Stroganova Tatiana A. , Orekhova Elena V. 
Published: October 2024

Abstract

Background
Difficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory “object”.
Methods
We used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio.
Results
SPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at ~ 150–200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise
Conclusions
These results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise.
Comprehensive Analysis of Combining Ability and Genetic Parameters for Green Fodder Yield and Quality Traits in Indian Cowpea (Vigna unguiculata L.)
Authors: THAKUR MUKUND KUMAR , THAILAPPAN EZHILARASI , RAMAMOORTHY PUSHPAM , KAVITHA S , S.R RANGASAMI 
Published: October 2024

Abstract

Target traits in hybrid breeding programs are crucial as they are highly responsive to gene action and combining ability. The line × tester method aids in understanding the genetic interactions influencing these traits, enabling the development of superior hybrids by selecting parent combinations that optimize heterosis or hybrid vigor. The study involved 23 forage cowpea genotypes and 3 testers, resulting in 69 F1 hybrids produced at Tamil Nadu Agricultural University, Coimbatore. The experiment was conducted over two cropping seasons (2023–2024) at the New Area Farm Experimental Station. A Randomized Complete Block Design (RCBD) with three replications was employed. The line × tester interaction was highly significant for all traits, indicating the impact of additive and non-additive gene expression variations. Notably, specific genotypes displayed significant General Combining Ability (GCA) effects: GETC 21 for Crude Protein (CPR), GETC 49 for Number of Leaves (NOL) and CPR, and CL 348 for Dry Matter Yield (DMY) and Crude Fiber (CFR). Additionally, hybrids demonstrated substantial Specific Combining Ability (SCA) effects, particularly CS 98 × CO 9 and CL 321-1 × CO(FC) 8 for DMY, and GETC 49 × CO(FC) 8 and GETC 49 × CO 9 for days to fifty percent flowering (DFF). Mid-parent heterosis was evident, with IFC 9402 × CO(FC) 8 showing the highest heterosis for plant height and FD 1052 × TNFC0926 for CPR. These results underscore the importance of selecting lines and testers with high GCA and hybrids with high SCA to enhance Green Forage Yield (GFY), DMY, CPR, CFR, and NOL in forage cowpea. This approach promises the development of new, high-yielding, and nutritionally superior cowpea varieties.
Gluconate solutions for nickel electrodeposition and nickel electroless plating
Authors: Afonin E. G. 
Published: October 2024

Nickel electroplating has found a wide range of industrial applications as a technique for creating protective and decorative coatings of metallic and non-metallic surfaces, protecting materials against corrosion at elevated temperatures in both alkaline environments and organic acid solutions, forming a sublayer for obtaining coatings of other metals on steel, enhancing the hardness and wear resistance of surfaces, as well as for improving solderability. Such coatings can be obtained from weakly acidic aqueous and weakly alkaline complex electrolytes. In this review, we analyze the available literature on complexation of nickel(+2) with D-gluconate ion CH2OH(CHOH)4COO‾, along with that on compositions and some technological characteristics of complex D-gluconate solutions for nickel electrodeposition and electroless plating. Thus, a corrosion-resistant smooth light-colored nickel coating, tightly adhered to a copper substrate, was obtained from an electrolyte with a pH level of 8, containing 53 g/dm3 of NiSO4 •6H2O, 44 g/dm3 of D-C6H11O7Na, 25 g/dm3 of H3BO3, 53 g/dm3 of (NH4)2SO4, and 0.5–3 g/dm3 of CO(NH2)2, at a temperature of 25 °C, a cathodic current density of 2.5 A/dm2 with a current efficiency of 96.4%. An electroless Ni-P(3–18 wt%) alloy coating on copper was obtained from a solution with a pH level of 9, containing 5–30 g/dm3 of NiSO4 •6H2O, 10–60 g/dm3 of D-C6H11O7Na, 5–40 g/dm3 of NaH2PO2 •H2O, 3 g/dm3 of HOOCCH2CH2COOH, 0.5 g/dm3 of CH3(CH2)11OSO3Na, 0.002 g/dm3 of Pb(CH3COO)2•3H2O, at a temperature of 90 °C and a deposition rate of up to 0.75 μm/min. The review also discusses methods for preparing D-gluconate electrolytes for nickel plating using sodium D-gluconate, D-glucono-1,5-lactone, and nickel D-gluconate. One advantage of D-gluconate nickel plating solutions consists in the absence of toxicity and low cost of D-gluconates.
Design of Novel Imidazole Derivatives as Potential Non-nucleoside Reverse Transcriptase Inhibitors using Molecular Docking and Dynamics Strategies
Authors: Chandra Priyanka , Ganguly Swastika , Deb Pran Kishore , Ghosh Manik 
Published: October 2024

Introduction:
Human Immunodeficiency Virus (HIV) has become an epidemic causing Acquired
Immunodeficiency Syndrome (AIDS). Highly Active Antiretroviral Therapy (HAART) consists of Nucleoside
Reverse Transcriptase Inhibitors (NRTIS), Nucleotide Reverse Transcriptase Inhibitors (NtRTIS), and
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIS) with HIV Protease Inhibitors (HIV PIs). However,
the emergence of resistant strains of NNRTIS necessitates the search for better HIV-1-RT inhibitors

Methods:
In this study, a series of novel imidazoles (SP01-SP30) was designed using molecular docking inside
the non-nucleoside inhibitory binding pocket (NNIBP) of the HIV-1-RT (PDB ID-1RT2) using Glide
v13.0.137, Autodock Vina, and FlexX v2.1.3. Prime MMGBSA was used to study the free energy of binding
of the inhibitors with the target enzyme. Molecular dynamics simulation studies were carried out to discover
the dynamic behavior of the protein as well as to unveil the role of the essential amino acids required for the
better binding affinity of the inhibitor within the NNIBP of the enzyme. The QikProp software module of
Schrodinger and online SwissADME were also used to evaluate the drug-likeliness of these compounds.

Results:
The imidazole derivative SP08 is predicted to be the most promising design compound that can be
considered for further synthetic exploitations to obtain a molecule with the highest therapeutic index against
HIV-1-RT.

Conclusion:
The results of the current study demonstrate the robustness of our in silico drug design strategy
that can be used for the discovery of novel HIV-1-RT inhibitors.
Tumor-Activated Neutrophils Promote Lung Cancer Progression through the IL-8/PD-L1 Pathway
Authors: Zheng Yiping , Cai Jianfeng , Ji Qiuhong , Liu Luanmei , Liao Kaijun , Dong Lie , Gao Jie , Huang Yinghui 
Published: October 2024

Background:
Lung cancer remains a major global health threat due to its complex microenvironment,
particularly the role of neutrophils, which are crucial for tumor development and
immune evasion mechanisms. This study aimed to delve into the impact of lung cancer cell-conditioned
media on neutrophil functions and their potential implications for lung cancer progression.

Methods:
Employing in vitro experimental models, this study has analyzed the effects of lung cancer
cell-conditioned media on neutrophil IL-8 and IFN-γ secretion, apoptosis, PD-L1 expression,
and T-cell proliferation by using techniques, such as ELISA, flow cytometry, immunofluorescence,
and CFSE proliferation assay. The roles of IL-8/PD-L1 in regulating neutrophil functions were further
explored using inhibitors for IL-8 and PD-L1.

Results:
Lung cancer cell lines were found to secrete higher levels of IL-8 compared to normal
lung epithelial cells. The conditioned media from lung cancer cells significantly reduced apoptosis
in neutrophils, increased PD-L1 expression, and suppressed T-cell proliferation and IFN-γ secretion.
These effects were partially reversed in the presence of IL-8 inhibitors in Tumor Tissue Culture
Supernatants (TTCS), while being further enhanced by IL-8. Both apoptosis and PD-L1 expression
in neutrophils demonstrated dose-dependency to TTCS. Additionally, CFSE proliferation assay
results further confirmed the inhibitory effect of lung cancer cell-conditioned media on T-cell
proliferation.

Conclusion:
This study has revealed lung cancer cell-conditioned media to modulate neutrophil
functions through regulating factors, such as IL-8, thereby affecting immune regulation and tumor
progression in the lung cancer microenvironment.
INCORPORATING ETHNOMATHEMATICS AND REALISTIC MATHEMATICS EDUCATION ON DEVELOPING MATHEMATICS CONNECTION USING THE MENARA KUDUS
Authors: Sari Sellanidia Antika , Nisa’ Silvia Durrotun , As-salamah Siti Fatimah , Maharani Rizqona 
Published: October 2024

This research was motivated by students' low mathematical connections and lack of knowledge about the local culture around where they live. This research aims to develop a student digital worksheet using the concepts of ethnomathematics and Realistic Mathematics Education following the ADDIE procedure. A number of 30 students of year five in a primary school in Kudus District, Province of Central Java, Indonesia, involved in the study. The learning material used the local cultural object namely Menara Kudus. This bulding is part of muslim gathering venue and known its adaptation to the Hinduism as it was built during the era. A digital worksheet is defined as a set learning activity that can be accessed using electronic gadgets, like computer or smartphone. Validation of the development resutls included experts and students to collect data on the feasibility assessment of the digital worksheet which consists of assessments by material experts and media experts. In addition, the use of web based interactive worksheets at Menara Kudus based on Ethno–RME shows a significant increase in students' mathematical connections. This means that the Ethno–RME based Digital worksheet at the Menara Kudus was declared feasible and can be used in mathematics learning.
Penerapan Model Pembelajaran Kooperatif Tipe Jigsaw dalam Meningkatkan Hasil Belajar Siswa Mata Pelajaran Pendidikan Agama Islam di SMP Negeri 37 Konawe Selatan
Authors: Sufiani Sufiani , Putra Aris Try Andreas 
Published: October 2024

<p>Penelitian ini bertujuan untuk<em> </em>mendeskripsikan penerapan model pembelajaran kooperatif tipe <em>Jigsaw </em> dalam meningkatkan hasil belajar siswa mata pelajaran Pendidikan Islam pada kelas VIII di SMP Negeri 37 Konawe Selatan. Jenis penelitian ini adalah penelitian tindakan kelas (PTK) dengan prosedur penelitian dalam dua siklus dan beberapa tahapan yaitu perencanaan, tindakan, pengamatan dan refleksi. Teknik pengumupalan data yang digunakan yaitu observasi, tes hasil belajar dan dokumentasi. Observasi dilakukan untuk mengetahui aktivitas guru dan siswa dalam pelaksanaan pembelajaran. Tes hasil belajar dilaksanakan untuk menentukan ketuntasan hasil belajar siswa. Sedangkan dokumentasi digunakan untuk mendapatkan data tentang keadaan dan jumlah siswa yang akan diteliti pada kelas VIII SMP Negeri 37 Konawe Selatan yakni 33 siswa. Dari hasil penelitian menunjukkan, siswa yang memperoleh nilai 70 ke atas pada tes awal prasiklus sebanyak 14 siswa (42,42%) . Setelah pelaksanaan siklus I, siswa yang mencapai ketuntasan hasil belajar di atas nilai 70 sejumlah 23 siswa (69,70%). Selanjutnya setelah pelaksanaan siklus II, siswa yang memperoleh nilai di atas 70 berjumlah 29 siswa (87,88%) dan mencapai ketuntasan belajar secara kalsikal yakni di atas 80%.</p><p><strong>Kata Kunci</strong> : <em>Jigsaw</em>, Hasil Belajar, Pendidikan Agama Islam.</p>
Living Values Education Program (LVEP) Sebagai Penguatan Profil Pelajar Pancasila Peserta Didik Dalam Kurikulum Merdeka
Authors: Apriani An-Nisa , Komalasari Mahilda Dea 
Published: October 2024

<p>Kurikulum Merdeka telah berhasil mengintegrasikan pendidikan karakter melalui profil pelajar pancasila, namun tantangan-tantangan dalam implementasi masih terlihat. Seperti kurangnya pemahaman dan penerapan guru dalam mengintegrasikan pendidikan karakter profil pelajar Pancasila dalam proses pembelajaran sehingga berdampak pada krisis moral peserta didik. Dalam menghadapi tantangan ini, salah satu strategi atau model pembelajaran yang dapat diimplementasikan dalam pembelajaran untuk memastikan integrasi pendidikan karakter yang efektif dan konsisten guna memperkuat profil pelajar Pancasila pada peserta didik yaitu <em>Living Values: An Educational Program</em> (LVEP). Penelitian ini bertujuan untuk memaparkan tentang cara penguatan profil pelajar Pancasila dalam kurikulum Merdeka melalui Living Values Education Program (LVEP). Penelitian ini merupakan penelitian kualitatif deskriptif dengan tinjauan pustaka. Prosedur pengumpulan data penelitian terdiri dari: 1) editing; 2). organizing; dan 3) finding.Uji validitas yang digunakan yairu triangulasi sumber data.Teknik analisis data yang digunakan antara lain pengumpulan data, reduksi data, penyajian data (display data), selanjutnya penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa <em>Living Values Education Program</em> dapat diterapkan oleh guru-guru sebagai salah satu strategi atau program unggulan dalam penguatan profil pelajar Pancasila bagi peserta didik dalam proses pembelajaran sehingga peserta didik memiliki moral yang baik dan berakhlak mulia. LVEP mencakup aktivitas-aktivitas nilai seperti berefleksi, berimajinasi, berdialog, berkomunikasi, berkreasi, mebuat tulisan, kkarya seni, lagu-lagu, dan bermain dengan nilai-nilai yang diajarkan. Aktivitas LVEP dirancang untuk mengajak pesreta didik untuk memikirkan diri sendiri, orang lain dan dunia serta mendalami, mengalami, dan mengeksplorasi tentang nilai dalam kehidupan sehari-hari sehingga peserta didik memperoleh pengalaman langsung yang bermakna.</p><p> </p><strong>Kata Kunci: </strong><em>Living Values Education Program, Profil Pelajar Pancasila, Kurikulum Merdeka</em>
The Effect of Nature of Critical Audit Matters and Outcome Indication on Investors’ Decisions
Authors: Goh Clarence , Meyer Peter , Pornupatham Sompong , Tan Hun-Tong , Vichitsarawong Thanyaluk 
Published: October 2024

ABSTRACT
Two aspects of critical audit matter (CAM) disclosure are (1) whether it relates to complexity in audit judgments (complex CAM) or uncertainty in underlying management estimates (uncertain CAM) and (2) whether an indication of the outcome of audit procedures performed to address the CAM is included in the disclosure. We use two controlled experiments to examine the joint effects of CAM nature and the presence of a CAM outcome indication on investors’ judgments of investment attractiveness. In the first (second) experiment, we used a stronger (weaker) outcome indication, which provides stronger (weaker) conclusions about the audit procedures performed to address the CAM. We find that the provision of a stronger (weaker) outcome indication increases investment attractiveness judgments to a greater (an equal) extent for an uncertain CAM than for a complex CAM.
Data Availability: Please contact the authors.
The Relevance of Indicator Assessment for Planning and Decision-Making in Urban Monitoring
Authors: Alves Junior Luiz Lucas , Guedes Leonardo Guerra de Rezende 
Published: October 2024

Objective: The objective of this study is to investigate the application of information systems in urban monitoring management, specifically focusing on the analysis of indicators that can support decision-making. The study aims to explore which indicators are associated with monitoring management, their correlations with various provided services, and the triggers that activate these services.

Theoretical Framework: This research is grounded in Contingency Theory, which posits that organizational effectiveness is contingent on how practices are adapted to specific contexts. Key concepts include the integration of information systems, data-driven decision-making, and urban management efficiency.

Method: The methodology employed involves a combination of quantitative and qualitative data collection and analysis methods. This approach provides a comprehensive and contextualized understanding of urban monitoring operations. Data collection methods include [specify methods used, e.g., surveys, interviews, or observations].

Results and Discussion: The findings demonstrate the critical role of integrating information systems with everyday monitoring practices, allowing for the extraction and application of accurate and relevant data to enhance urban service management. The discussion highlights the implications of these findings within the theoretical framework, examining the relationships and discrepancies identified and considering the study's limitations.

Research Implications: The study provides both theoretical and practical implications, offering insights into how the findings can be applied to improve practices in urban management. The implications are particularly relevant for enhancing the responsiveness and adaptability of urban monitoring strategies.

Originality/Value: This study contributes to the literature by offering a novel perspective on the integration of information systems in urban monitoring, highlighting the importance of data-driven decision-making. The research's relevance is underscored by its potential to influence urban management practices and improve service quality.
Teaching Challenges in the School Context of the Mapuá River in the Municipality of Breves in Pará-Brasil and the Transformations of the Ribeirinha School
Authors: Fonseca Quesia Raquel da Silva , Pereira Vilmar Alves 
Published: October 2024

Objective: This article is part of a doctoral thesis and aims to understand the teaching challenges of Popular Educators in the context of Ribeirinhas do Campo Schools. In addition to investigating the processes of teacher constitution and training trajectory, the study takes as a reference the context of Northern Brazil of Ribeirinha Schools on the Mapuá River, Municipality of Breves in Pará.

Theoretical Framework: The study uses theoretical references that bring together authors from Rural Education and Popular Education in approaching the Ribeirinha School as one of the expressions of this theoretical horizon. This demarcation greatly contributes to possible transformations of the Ribeirinha School in the Amazon context.

Method: The nature of the research is qualitative and prioritizes, as an instrument, open or in-depth questions. Initially, the study carried out a broad contextualization, which brought the universe of the Ribeirinha School closer to the context of Popular Education and Rural Education. Secondly, the research aims to present the perceptions of Educators who work in these contexts.

Results and Discussion: The results obtained revealed a transformation in riverside education in several aspects, which is evidenced in this article, associating riverside reality and culture, with school education, which brings the curriculum closer to the riverside experience, mixing realities, as well as understanding about planning. curriculum in accordance with the culture of rivers and forests, linking school knowledge to riverside work, with an education that enables the preservation of students' identity and school training.

Research Implications: The practical and theoretical implications of this research demonstrate the fruitfulness of the discussion that brings together Rural Education, Popular Education and Riverside School in strengthening the field of Popular Education that dialogues with knowledge and that demands the need for another Pedagogical Project and another curriculum for the Riverside School.

Originality/Value: This study contributes to the literature due to the fact that readings of the Ribeirnha School are usually presented in a decontextualized manner. This research overcomes this view and indicates a fruitful path through the critical and popular horizon of a historical materialist matrix.
Pengaruh Pijat Akupresur Laktasi (Akuprelaktasi) terhadap Produksi ASI pada Ibu Nifas di Kabupaten Tegal
Authors: Rahmanindar Nora , Nisa Juhrotun 
Published: October 2024

Di Kabupaten Tegal tahun 2022 cakupan bayi dibawah 6 bulan yang hanya mendapat ASI ekslusif sebesar 67,96%, Pemerintah kabupaten Tegal saat ini terus berupaya untuk tahun 2026 cakupan bayi usia kurang dari 6 bulan yang mendapatkan ASI ekslusif sebesar 85%. Tujuan Penelitian ini untuk mengetahui adanya pengaruh pijat akupresure laktasi terhadap produksi ASI pada ibu nifas. Penelitian dengan metode kuantitatif memakai rancangan quasy experimental design dengan desain non equivalent control grup design. Populasi dalam penelitian ini adalah ibu nifas di Kabupaten Tegal yaitu 100 orang ibu nifas. Periode pengambilan bulan November-Desember 2023, sampel yang digunakan seluruh ibu nifas hari ke 1-3, Teknik pengambilan sampel menggunakan teknik cluster sampling, 50 ibu nifas pada kelompok perlakuan dan 50 ibu nifas pada kelompok kontrol. Hasil uji statistic menggunakan Wilcoxon didapatkan P-value 0,000 pada derajat kemaknaan 5% (0,000<0,005), dalam hal ini menunjukan bahwa hipotesis penelitian diterima artinya ada pengaruhnya pijat Akupresure laktasi terhadap produksi ASI ada ibu nifas.
COMBATTING CORRUPTION IN INDONESIAN REGIONAL GOVERNANCE: STRATEGIES, CHALLENGES, AND PATHWAYS TO STABILITY
Authors: Wijanarko Dwi Seno 
Published: October 2024

This study investigates initiatives aimed at the local government level to end criminal acts of corruption. The persistence challenge of corruption in Indonesia especially within the regional governance still happening despite extensive anti-corruption initiatives in the country. By examining the multifaceted modus operandi across the local government it will uncovering the menacing threat that corruption poses to the stability of the regional governance, if not, the country. Analyzing how well local governments use procedures and techniques to combat corruption is the primary goal of their research. The study results offer a comprehensive understanding of the difficulties and roadblocks encountered in attempts to end corruption on a regional scale. Furthermore, this study also finds contributing elements that can boost anti-corruption initiatives' efficacy. The anticipated outcomes are anticipated to enhance comprehension of the mechanisms involved in eliminating corruption at the local government level and offer a foundation for enhancing policies and putting them into effect.