bluuebunny/crossref_metadata_2025_split huggingface dataset:
PA‐MSHA inhibits the growth of doxorubicin‐resistant MCF‐7/ADR human breast cancer cells by downregulating Nrf2/p62
Authors: Wei Yingze , Liu Danyang , Jin Xiaoxia , Gao Pan , Wang Qingying , Zhang Jiawen , Zhang Nong 
Published: October 2016

AbstractAcquired resistance to doxorubicin in breast cancer is a serious therapeutic problem. In this study, we investigated whether Pseudomonas aeruginosa mannose‐sensitive hemagglutinin (PA‐MSHA) could inhibit the growth of doxorubicin‐resistant breast cancer cells. We found that the expressions of Nrf2 and p62 in breast cancer were higher than that in the corresponding adjacent normal tissues and benign breast epithelial cell. The expressions of Nrf2 and p62 in breast cancer doxorubicin‐resistant cells MCF‐7/ADR were higher than that in doxorubicin‐sensitive cells MCF‐7. Silencing of Nrf2 or p62 rendered breast cancer cells more susceptible to doxorubicin. We further demonstrated that PA‐MSHA inhibited growth and induced apoptosis of MCF‐7/ADR cells but not MCF‐7 cells. Subcutaneous administration of PA‐MSHA greatly inhibited the growth of xenograft tumors from MCF‐7/ADR cells in nude mice. In addition, PA‐MSHA could downregulate Nrf2 and p62 in vitro and in vivo. These results suggested that activation of Nrf2 and p62 was associated with doxorubicin resistance in breast cancer. PA‐MSHA could inhibit the growth of doxorubicin‐resistant MCF‐7/ADR cells and its potential mechanism might be due to the suppression of Nrf2/p62. It indicated the possibility of using PA‐MSHA in doxorubicin‐resistant breast cancer.
A theoretical review of consumer priming: Prospective theory, retrospective theory, and the affective–behavioral–cognitive model
Authors: Minton Elizabeth A. , Cornwell T. Bettina , Kahle Lynn R. 
Published: October 2016

ABSTRACTPrimes are pervasive in marketing. Despite frequent use in practice, there has yet to be a framework to categorize priming techniques that is inclusive of measurement challenges and methods for administering primes as well as provides insight for researchers on how to think about and construct research using priming. Prior researchers have provided reviews of priming research, which have set the stage for discussions of priming theories and challenges of using primes in survey research. We build from their review and contribute in four ways by (i) reviewing priming theories rooted in both prospective and retrospective models of memory; (ii) developing a priming framework based on the ABC model of attitudes (affective, behavioral, and cognitive priming) that incorporates lexical priming, priming fluency effects, and methods for administering primes; (iii) addressing priming challenges including discrepancies between the priming method and measurement method; and (iv) positing the influence of personal characteristics on priming, such as the role of skepticism in assimilation and contrast effects. The final model is offered and elaborated upon as a guide for future research. Copyright © 2016 John Wiley & Sons, Ltd.
Enantioselective Intramolecular Reductive Heck Reaction with a Palladium/Monodentate Phosphoramidite Catalyst
Authors: Mannathan Subramaniyan , Raoufmoghaddam Saeed , Reek Joost N. H. , de Vries Johannes G. , Minnaard Adriaan J. 
Published: October 2016

AbstractA palladium‐catalyzed enantioselective reductive Heck reaction of enones using monodentate phosphoramidite ligands is described. α,α,α’,α’‐tetraaryl‐1,3‐dioxolane‐4,5‐dimethanol (TADDOL)‐based phosphoramidites with palladium(II) acetate, and N‐methyl dicyclohexylamine as reducing agent gives the reductive Heck product in high yields and enantioselectivities of up to 90 %. The solvent plays an important role and in diethyl carbonate, the chemo‐ and enantioselectivity appeared to be the highest.
Structure‐Guided Redesign of CYP153AM.aq for the Improved Terminal Hydroxylation of Fatty Acids
Authors: Hoffmann Sara M. , Danesh‐Azari Hamid‐Reza , Spandolf Claudia , Weissenborn Martin J. , Grogan Gideon , Hauer Bernhard 
Published: October 2016

AbstractThe front cover artwork for Issue 20/2016 is provided by researchers from the Universität Stuttgart (Germany) and the University of York (United Kingdom). The image shows a free fatty acid substrate which drops into the active site of a P450 enzyme in an aqueous solution. The fatty acid is kept in the splash through the specific structural elements of the enzyme. See the Full Paper itself at http://dx.doi.org/10.1002/cctc.201600680.
Ubiquitin Associates with the N‐Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions
Authors: Lanza Valeria , Travaglia Alessio , Malgieri Gaetano , Fattorusso Roberto , Grasso Giuseppe , Di Natale Giuseppe , Zito Valeria , Arena Giuseppe , Milardi Danilo , Rizzarelli Enrico 
Published: October 2016

AbstractMany biochemical pathways involving nerve growth factor (NGF), a neurotrophin with copper(II) binding abilities, are regulated by the ubiquitin (Ub) proteasome system. However, whether NGF binds Ub and the role played by copper(II) ions in modulating their interactions have not yet been investigated. Herein NMR spectroscopy, circular dichroism, ESI‐MS, and titration calorimetry are employed to characterize the interactions of NGF with Ub. NGF1–14, which is a short model peptide encompassing the first 14 N‐terminal residues of NGF, binds the copper‐binding regions of Ub (KD=8.6 10−5 m). Moreover, the peptide undergoes a random coil–polyproline type II helix structural conversion upon binding to Ub. Notably, copper(II) ions inhibit NGF1–14/Ub interactions. Further experiments performed with the full‐length NGF confirmed the existence of a copper(II)‐dependent association between Ub and NGF and indicated that the N‐terminal domain of NGF was a valuable paradigm that recapitulated many traits of the full‐length protein.
Multiscale Computational Study on the Adsorption and Separation of CO2/CH4 and CO2/H2 on Li+‐Doped Mixed‐Ligand Metal–Organic Framework Zn2(NDC)2(diPyNI)
Authors: Sokhanvaran Vahid , Yeganegi Saeid 
Published: October 2016

AbstractThe quantum mechanics (QM) method and grand canonical Monte Carlo (GCMC) simulations are used to study the effect of lithium cation doping on the adsorption and separation of CO2, CH4, and H2 on a twofold interwoven metal–organic framework (MOF), Zn2(NDC)2(diPyNI) (NDC=2,6‐naphthalenedicarboxylate; diPyNI=N,N′‐di‐(4‐pyridyl)‐1,4,5,8‐naphthalenetetracarboxydiimide). Second‐order Moller–Plesset (MP2) calculations on the (Li+–diPyNI) cluster model show that the energetically most favorable lithium binding site is above the pyridine ring side at a distance of 1.817 Å from the oxygen atom. The results reveal that the adsorption capacity of Zn2(NDC)2(diPyNI) for carbon dioxide is higher than those of hydrogen and methane at room temperature. Furthermore, GCMC simulations on the structures obtained from QM calculations predict that the Li+‐doped MOF has higher adsorption capacities than the nondoped MOF, especially at low pressures. In addition, the probability density distribution plots reveal that CO2, CH4, and H2 molecules accumulate close to the Li cation site. The selectivity results indicate that CO2/H2 selectivity values in Zn2(NDC)2(diPyNI) are higher than those of CO2/CH4. The selectivity of CO2 over CH4 on Li+‐doped Zn2(NDC)2(diPyNI) is improved relative to the nondoped MOF.
Stable isotope‐based trophic structure of pelagic fish and jellyfish across natural and anthropogenic landscape gradients in a fjord estuary
Authors: Naman Sean M. , Greene Correigh M. , Rice Casimir A. , Chamberlin Joshua , Conway‐Cranos Letitia , Cordell Jeffery R. , Hall Jason E. , Rhodes Linda D. 
Published: October 2016

AbstractIdentifying causes of structural ecosystem shifts often requires understanding trophic structure, an important determinant of energy flow in ecological communities. In coastal pelagic ecosystems worldwide, increasing jellyfish (Cnidaria and Ctenophora) at the expense of small fish has been linked to anthropogenic alteration of basal trophic pathways. However, this hypothesis remains untested in part because baseline description of fish–jellyfish trophic dynamics, and the environmental features that influence them are lacking. Using stable isotopes of carbon (δ13C) and nitrogen (δ15N), we examined spatiotemporal patterns of fish and jellyfish trophic structure in greater Puget Sound, an urbanizing fjord estuary in the NW United States. We quantified niche positions of constituent species, niche widths and trophic overlap between fish and jellyfish assemblages, and several community‐level trophic diversity metrics (resource diversity, trophic length, and niche widths) of fish and jellyfish combined. We then related assemblage‐ and community‐level measures to landscape gradients of terrestrial–marine connectivity and anthropogenic influence in adjacent catchments. Relative niche positions among species varied considerably and displayed no clear pattern except that fish generally had higher δ15N and lower δ13C relative to jellyfish, which resulted in low assemblage‐level trophic overlap. Fish assemblages had larger niche widths than jellyfish in most cases and, along with whole community trophic diversity, exhibited contrasting seasonal patterns across oceanographic basins, which was positively correlated to landscape variation in terrestrial connectivity. In contrast, jellyfish niche widths were unrelated to terrestrial connectivity, but weakly negatively correlated to urban land use in adjacent catchments. Our results indicate that fish–jellyfish trophic structure is highly heterogeneous and that disparate processes may underlie the trophic ecology of these taxa; consequently, they may respond divergently to environmental change. In addition, spatiotemporal variation in ecosystem connectivity, in this case through freshwater influence, may influence trophic structure across heterogeneous landscapes.
Impact of urbanization and gardening practices on common butterfly communities in France
Authors: Fontaine Benoît , Bergerot Benjamin , Le Viol Isabelle , Julliard Romain 
Published: October 2016

AbstractWe investigated the interacting impacts of urban landscape and gardening practices on the species richness and total abundance of communities of common butterfly communities across France, using data from a nationwide monitoring scheme. We show that urbanization has a strong negative impact on butterfly richness and abundance but that at a local scale, such impact could be mitigated by gardening practices favoring nectar offer. We found few interactions among these landscape and local scale effects, indicating that butterfly‐friendly gardening practices are efficient whatever the level of surrounding urbanization. We further highlight that species being the most negatively affected by urbanization are the most sensitive to gardening practices: Garden management can thus partly counterbalance the deleterious effect of urbanization for butterfly communities. This holds a strong message for park managers and private gardeners, as gardens may act as potential refuge for butterflies when the overall landscape is largely unsuitable.
Impact of haemoconcentration during acute heart failure therapy on mortality and its relationship with worsening renal function
Authors: Breidthardt Tobias , Weidmann Zoraida Moreno , Twerenbold Raphael , Gantenbein Claudine , Stallone Fabio , Rentsch Katharina , Rubini Gimenez Maria , Kozhuharov Nikola , Sabti Zaid , Breitenbücher Dominik , Wildi Karin , Puelacher Christian , Honegger Ursina , Wagener Max , Schumacher Carmela , Hillinger Petra , Osswald Stefan , Mueller Christian 
Published: October 2016

AbstractAimsTreatment goals in acute heart failure (AHF) are poorly defined. We aimed to characterize further the impact of in‐hospital haemoconcentration and worsening renal function (WRF) on short‐ and long‐term mortality.Methods and resultsHaematocrit, haemoglobin, total protein, serum creatinine, and albumin levels were measured serially in 1019 prospectively enrolled AHF patients. Haemoconcentration was defined as an increase in at least three of four of the haemoconcentration‐defining parameters above admission values at any time during the hospitalization. Patients were divided into early (Day 1–4) and late haemoconcentration (>Day 4). Ninety‐day mortality was the primary endpoint. Haemoconcentration occurred in 392 (38.5%) patients, with a similar incidence of the early (44.6%) and late (55.4%) phenotype. Signs of decongestion (reduction in BNP blood concentrations, P = 0.003; weight loss, P = 0.002) were significantly more pronounced in haemoconcentration patients. WRF was more common in haemoconcentration patients (P = 0.04). After adjustment for established risk factors for AHF mortality, including WRF and HF therapy at discharge, haemoconcentration was significantly associated with a reduction in 90‐day mortality [hazard ratio (HR) 0.59, 95% confidence interval (CI) 0.37–0.95, P = 0.01]. The beneficial effect of haemoconcentration seemed to be exclusive for late haemoconcentration (late vs. early: adjusted HR 0.41, 95% CI 0.19–0.90, P = 0.03) and persisted in patients with or without WRF.ConclusionsHaemoconcentration represents an inexpensive and easily assessable pathophysiological signal of adequate decongestion in AHF and is associated with lower mortality. WRF in the setting of haemoconcentration does not appear to offset the benefits of haemoconcentration.
Camera system considerations for geomorphic applications of SfM photogrammetry
Authors: Mosbrucker Adam R. , Major Jon J. , Spicer Kurt R. , Pitlick John 
Published: October 2016

AbstractThe availability of high‐resolution, multi‐temporal, remotely sensed topographic data is revolutionizing geomorphic analysis. Three‐dimensional topographic point measurements acquired from structure‐from‐motion (SfM) photogrammetry have been shown to be highly accurate and cost‐effective compared to laser‐based alternatives in some environments. Use of consumer‐grade digital cameras to generate terrain models and derivatives is becoming prevalent within the geomorphic community despite the details of these instruments being largely overlooked in current SfM literature.A practical discussion of camera system selection, configuration, and image acquisition is presented. The hypothesis that optimizing source imagery can increase digital terrain model (DTM) accuracy is tested by evaluating accuracies of four SfM datasets conducted over multiple years of a gravel bed river floodplain using independent ground check points with the purpose of comparing morphological sediment budgets computed from SfM‐ and LiDAR‐derived DTMs. Case study results are compared to existing SfM validation studies in an attempt to deconstruct the principle components of an SfM error budget.Greater information capacity of source imagery was found to increase pixel matching quality, which produced eight times greater point density and six times greater accuracy. When propagated through volumetric change analysis, individual DTM accuracy (6–37 cm) was sufficient to detect moderate geomorphic change (order 100 000 m3) on an unvegetated fluvial surface; change detection determined from repeat LiDAR and SfM surveys differed by about 10%. Simple camera selection criteria increased accuracy by 64%; configuration settings or image post‐processing techniques increased point density by 5–25% and decreased processing time by 10–30%.Regression analysis of 67 reviewed datasets revealed that the best explanatory variable to predict accuracy of SfM data is photographic scale. Despite the prevalent use of object distance ratios to describe scale, nominal ground sample distance is shown to be a superior metric, explaining 68% of the variability in mean absolute vertical error. Published 2016. This article is a U.S. Government work and is in the public domain in the USA
Identifying the Critical Success Factors and an Optimal Solution for Mobile Technology Adoption in Travel Agencies
Authors: Lin Sheng‐Wei 
Published: October 2016

AbstractTo effectively use of mobile technologies, this study develops a multifaceted framework to analyze critical success factors and determine an optimal solution for mobile technology adoption by using hybrid multiple criteria decision‐making methods. The results show that the most important and common critical success factors (CSFs) are top management support and consumer needs. Meanwhile, experienced adopters also addressed market trends and customer relationships, as well as prioritized the adoption of mobile websites, whereas potential adopters were concerned about organizational innovativeness and considered quick response (QR) codes as the most suitable mobile technology. Finally, some academic and managerial implications are offered at the end of the study. Copyright © 2016 John Wiley & Sons, Ltd.
Stability and optimal control of a delayed HIV model
Authors: Rocha Diana , Silva Cristiana J. , Torres Delfim F. M. 
Published: October 2016

We propose and investigate a delayed model that studies the relationship between HIV and the immune system during the natural course of infection and in the context of antiviral treatment regimes. Sufficient criteria for local asymptotic stability of the infected and viral free equilibria are given. An optimal control problem with time delays both in state variables (incubation delay) and control (pharmacological delay) is then formulated and analyzed, where the objective consists to find the optimal treatment strategy that maximizes the number of uninfected CD4 + T cells as well as cytotoxic T lymphocyte immune response cells, keeping the drug therapy as low as possible. Copyright © 2016 John Wiley & Sons, Ltd.
Pulmonary relaxometry with inversion recovery ultra‐fast steady‐state free precession at 1.5T
Authors: Bauman Grzegorz , Santini Francesco , Pusterla Orso , Bieri Oliver 
Published: October 2016

PurposeTo present a technique for simultaneous mapping of T1, T2, and relative spin density (M0) in human lung using inversion recovery ultra‐fast steady‐state free precession (IR‐ufSSFP) imaging.MethodsPulmonary relaxometry with IR‐ufSSFP is based on an interleaved time series acquisition of 2D images acquired at 1.5T. The technique was tested in a phantom and in four healthy volunteers using breath‐hold and electrocardiogram triggering. Typically, 30 transient state images were acquired in a single breath‐hold within < 10 s. From the signal time course, voxel‐wise nonlinear fitting yielded T1, T2, and M0 parameter maps. Furthermore, off‐resonance and B1 effects were investigated in a phantom.ResultsIn the phantom, the observed T1 of 829 ± 2 ms and T2 of 105 ± 4 ms were in agreement with the reference T1 of 858 ± 1 ms and T2 of 104 ± 1 ms using spin echo methods. In volunteers, the average T1 of 1375 ± 102 ms and T2 of 66 ± 26 ms of lung tissue were in good agreement with the literature and were observed to be independent of the respiratory phase. Overall, high reproducibility was shown in a volunteer, yielding coefficient of variations of 0.03 for M0, 0.004 for T1, and 0.04 for T2 measurements.ConclusionIR‐ufSSFP allows for fast and simultaneous quantitative mapping of the human lung. Magn Reson Med 77:74–82, 2017. © 2016 International Society for Magnetic Resonance in Medicine
Dysphagia‐related quality of life in oculopharyngeal muscular dystrophy: Psychometric properties of the SWAL‐QOL instrument
Authors: Youssof Sarah , Romero‐Clark Carol , Warner Teddy , Plowman Emily 
Published: October 2016

ABSTRACTIntroductionThe Swallowing Quality of Life instrument (SWAL‐QOL) is a patient‐reported outcome measure of swallowing‐related quality of life (SR‐QoL). Its psychometric properties in oculopharyngeal muscular dystrophy (OPMD) are not known.MethodsWe administered the SWAL‐QOL to U.S. OPMD Registry participants. We described SR‐QoL profiles and assessed reliability and validity.ResultsThe mean composite score in 113 individuals with OPMD was 54.4 ± 20.7, indicating moderate impairment. Severe impairments were observed in eating duration, burden, and fatigue scales. Internal consistency reliability of all scales was found to be satisfactory, and 9 of 10 scales demonstrated adequate test–retest reliability. Data confirmed 86% of hypotheses, supporting construct validity. The SWAL‐QOL limitations in OPMD include: floor/ceiling effects in 7 of 10 scales and low specificity of sleep, fatigue, and communication scales for dysphagia.ConclusionsSR‐QoL is reduced in OPMD. Given several limitations of the SWAL‐QOL, development of an improved dysphagia‐specific QoL instrument for OPMD is warranted. Muscle Nerve 56: 28–35, 2017.
Modification of the boundary integral equation for the Navier–Lamé equations in 2D elastoplastic problems and its numerical solving
Authors: Zieniuk Eugeniusz , Bołtuc Agnieszka 
Published: October 2016

SummaryThe paper presents the generalization of the modification of classical boundary integral equation and obtaining parametric integral equation system for 2D elastoplastic problems. The modification was made to obtain such equations for which numerical solving does not require application of finite or boundary elements. This was achieved through the use of curves and surfaces for modeling introduced at the stage of analytical modification of the classic boundary integral equation. For approximation of plastic strains the Lagrange polynomials with various number and arrangement of interpolation nodes were used. Reliability of the modification was verified on examples with analytical solutions. Copyright © 2016 John Wiley & Sons, Ltd.
Examining the relationship between multiple primary cancers and psychological distress: A review of current literature
Authors: Belcher Sarah M. , Hausmann Emilie A. , Cohen Susan M. , Donovan Heidi S. , Schlenk Elizabeth A. 
Published: October 2016

AbstractObjectiveThe incidence of multiple primary cancers (MPCs) is increasing, but little is known about psychological distress in this population. The purpose of this study is to review and synthesize the literature regarding what is known about psychological distress in adults who have experienced MPC diagnoses.MethodsAll potentially eligible studies identified in PubMed and CINAHL were reviewed by 2 independent evaluators, and each relevant article was assessed for methodological quality. Data were extracted, organized, and recorded using a coding log, PRISMA flow diagram, and a standardized table of evidence. Effect size (ES) values were calculated using Cohen's d.ResultsFive of the 562 potentially relevant articles were selected for final analysis. MPC survivors, when compared with single cancer survivors, had lower global quality of life (d = 0.32–0.37), poorer emotional role function and stress (d = 0.08–0.20), greater and more frequent distress (d = 0.11–0.37), and greater subclinical anxiety (d = 0.15). Depressive symptoms were variable (d = 0.01–0.22), and no differences between MPC and single cancer groups were identified for sleep and suicidal ideation.ConclusionThere is a substantial lack of evidence focused on psychological distress among the growing MPC survivor population. ES noted in the 5 studies reflect small but potentially significant increases in psychological distress in survivors of MPC compared with survivors of a single cancer. Clinicians should be aware of this at‐risk population when screening for distress in cancer survivors. Suggestions for future research are provided.