bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversibly pH‐Switchable Anionic‐Surfactant‐Based Emulsions
Authors: Chen Hui , Zhang Yuandi , Liu Xuefeng , Zhang Yongmin , Fang Yun 
Published: June 2017

AbstractTo develop a convenient and reversible strategy for phase separation and re‐emulsification of surfactant‐based emulsions, we established a method for pH switching of emulsions formed from a pH‐switchable anionic surfactant, potassium dodecyl seleninate (C12SeO2K). Upon acidification, C12SeO2K was protonated to give a precipitate of dodecyl seleninic acid (C12SeO2H); upon basification, C12SeO2H was neutralized restore C12SeO2K. The pH‐switchable window of the emulsion thus obtained was a pH range of 7 to 8. Reversible changes in both interfacial tension by ~10.2 mN m−1, as well as the mechanical, steric, and/or electrical barriers formed by C12SeO2K at the interface of the oil–aqueous solution account for the fully reversible phase separation and re‐emulsification of the C12SeO2K‐based emulsions. A stable emulsion (i.e. the time needed to separate 1 mL of H2O from 6 mL of emulsion at 25 °C is larger than 1 h) could be cycled at least 25 times when the pH was varied between 7 and 8.
Beyond symptom monitoring: Consumer needs for bipolar disorder self-management using smartphones
Authors: Nicholas J. , Boydell K. , Christensen H. 
Published: June 2017

AbstractObjectives:To investigate the potential use of smartphone apps to support self-management in young adults with bipolar disorder.Methods:We recruited 89 young adults (18–30 years) with bipolar disorder to complete a cross-sectional online survey. The survey contained quantitative and qualitative questions regarding technology use, current use of disorder-management apps, types of apps desired for disorder management, and app features that users would consider important when selecting apps. Results were analysed using descriptive statistics and thematic analysis.Results:Almost all participants used a smartphone daily and 40% currently used apps for disorder management. Of those not currently using apps, 79% indicated they would like to try them. On average, participants rated 61% of the self-management strategies listed as desirable for app support, with sleep-management, understanding early warning signs and triggers, and stay-well plans the most frequently endorsed. App features considered important during app selection were ease-of-use, scientific quality, flexibility/customisation, and data privacy.Conclusions:The results indicate that young adults with bipolar disorder are interested in a wide range of apps for self-management. Participants were interested in apps to support self-management strategies considered clinically important for disorder management. Many of these app needs are currently unmet. Results suggest diversifying and prioritising app capabilities to ensure evidence-based resources for a broader range of app functions are available to consumers.
Historical holdings and new dimensions: The Fashion Institute of Technology-SUNY Library Unit of Special Collections and College Archives
Authors: Trivette Karen Jamison 
Published: June 2017

The Fashion Institute of Technology (FIT)-SUNY Gladys Marcus Library's exquisite, rare, primary research materials are housed in its unit of Special Collections and College Archives; as such, it is known to those who study fashion and other creative industries throughout the world.Like the unit's name, its mission is two-fold: regarding special collections, it acquires, preserves, and provides access to a wide range of primary research materials in their original formats and across many languages and geographical spectra. All acquisitions support one or more curricula offered at FIT. Regarding the college archives, the unit acquires, preserves, and provides access to college records permanently-scheduled for retention, or deemed to have enduring, historical value, created or received in the course of college business; archival records are created or received by administrators, staff, faculty, and students. Fulfilling this mission supports myriad goals in and across FIT units as well as research from those outside the FIT community.This writer will introduce the collections to readers and briefly discuss the large-scale renovation that the unit is currently under-going.
Computer-Assisted Antimicrobial Recommendations for Optimal Therapy: Analysis of Prescribing Errors in an Antimicrobial Stewardship Trial
Authors: Schwartz David N. , McConeghy Kevin W. , Lyles Rosie D. , Wu Ulysses , Glowacki Robert C. , Itokazu Gail S. , Kieszkowski Piotr , Xiang Yingxu , Hota Bala , Weinstein Robert A. 
Published: June 2017

Clinician education and prospective audit and feedback interventions, deployed separately and concurrently, did not reduce antimicrobial use errors or rates compared to a control group of general medicine inpatients at our public hospital. Additional research is needed to define the optimal scope and intensity of hospital antimicrobial stewardship interventions.Infect Control Hosp Epidemiol2017;38:857–859
Dietary inflammatory index and risk of reflux oesophagitis, Barrett’s oesophagus and oesophageal adenocarcinoma: a population-based case–control study
Authors: Shivappa Nitin , Hebert James R. , Anderson Lesley A. , Shrubsole Martha J. , Murray Liam J. , Getty Lauren B. , Coleman Helen G. 
Published: June 2017

AbstractThe dietary inflammatory index (DIITM) is a novel composite score based on a range of nutrients and foods known to be associated with inflammation. DII scores have been linked to the risk of a number of cancers, including oesophageal squamous cell cancer and oesophageal adenocarcinoma (OAC). Given that OAC stems from acid reflux and that the oesophageal epithelium undergoes a metaplasia-dysplasia transition from the resulting inflammation, it is plausible that a high DII score (indicating a pro-inflammatory diet) may exacerbate risk of OAC and its precursor conditions. The aim of this analytical study was to explore the association between energy-adjusted dietary inflammatory index (E-DIITM) in relation to risk of reflux oesophagitis, Barrett’s oesophagus and OAC. Between 2002 and 2005, reflux oesophagitis (n219), Barrett’s oesophagus (n220) and OAC (n224) patients, and population-based controls (n256), were recruited to the Factors influencing the Barrett’s Adenocarcinoma Relationship study in Northern Ireland and the Republic of Ireland. E-DII scores were derived from a 101-item FFQ. Unconditional logistic regression analysis was applied to determine odds of oesophageal lesions according to E-DII intakes, adjusting for potential confounders. High E-DII scores were associated with borderline increase in odds of reflux oesophagitis (OR 1·87; 95 % CI 0·93, 3·73), and significantly increased odds of Barrett’s oesophagus (OR 2·05; 95 % CI 1·22, 3·47), and OAC (OR 2·29; 95 % CI 1·32, 3·96), when comparing the highest with the lowest tertiles of E-DII scores. In conclusion, a pro-inflammatory diet may exacerbate the risk of the inflammation-metaplasia-adenocarcinoma pathway in oesophageal carcinogenesis.
Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line
Authors: McCann Mark J. , Rotjanapun Kunjana , Hesketh John E. , Roy Nicole C. 
Published: June 2017

AbstractSe is an essential micronutrient for human health, and fluctuations in Se levels and the potential cellular dysfunction associated with it may increase the risk for disease. Although Se has been shown to influence several biological pathways important in health, little is known about the effect of Se on the expression of microRNA (miRNA) molecules regulating these pathways. To explore the potential role of Se-sensitive miRNA in regulating pathways linked with colon cancer, we profiled the expression of 800 miRNA in the CaCo-2 human adenocarcinoma cell line in response to a low-Se (72 h at <40 nm) environment using nCounter direct quantification. These data were then examined using a range ofin silicodatabases to identify experimentally validated miRNA–mRNA interactions and the biological pathways involved. We identified ten Se-sensitive miRNA (hsa-miR-93-5p, hsa-miR-106a-5p, hsa-miR-205-5p, hsa-miR-200c-3p, hsa-miR-99b-5p, hsa-miR-302d-3p, hsa-miR-373-3p, hsa-miR-483-3p, hsa-miR-512-5p and hsa-miR-4454), which regulate 3588 mRNA in key pathways such as the cell cycle, the cellular response to stress, and the canonical Wnt/β-catenin, p53 and ERK/MAPK signalling pathways. Our data show that the effects of low Se on biological pathways may, in part, be due to these ten Se-sensitive miRNA. Dysregulation of the cell cycle and of the stress response pathways due to low Se may influence key genes involved in carcinogenesis.
Effect Sizes of Model Misfit in Structural Equation	Models
Authors: Maydeu-Olivares Alberto , Shi Dexin 
Published: June 2017

Abstract. Residual correlations and covariances provide effect sizes of the misfit of covariance structure models. In a simulation study, we found that accurate confidence intervals (CIs) for standardized residual covariances are obtained even in small samples (N = 100), regardless of model size, degree of model misspecification, and data distribution. Standardized residual covariances also provide information about the source of misfit in poorly fitting models. From this viewpoint, they may be considered an alternative to modification indices. We compared the empirical Type I errors and power rates of standardized residual covariances and modification indices and found that both procedures provide nearly identical rates across the simulation conditions investigated. Residual correlations and standardized residual covariances provide very similar results.
Pomalidomide, bortezomib and low-dose dexamethasone in lenalidomide-refractory and proteasome inhibitor-exposed myeloma
Authors: Richardson P G , Hofmeister C C , Raje N S , Siegel D S , Lonial S , Laubach J , Efebera Y A , Vesole D H , Nooka A K , Rosenblatt J , Doss D , Zaki M H , Bensmaine A , Herring J , Li Y , Watkins L , Chen M S , Anderson K C 
Published: June 2017

Abstract
This phase 1 dose-escalation study evaluated pomalidomide, bortezomib (subcutaneous (SC) or intravenous (IV)) and low-dose dexamethasone (LoDEX) in lenalidomide-refractory and proteasome inhibitor-exposed relapsed or relapsed and refractory multiple myeloma (RRMM). In 21-day cycles, patients received pomalidomide (1–4 mg days 1–14), bortezomib (1–1.3 mg/m2 days 1, 4, 8 and 11 for cycles 1–8; days 1 and 8 for cycle ⩾9) and LoDEX. Primary endpoint was to determine the maximum tolerated dose (MTD). Thirty-four patients enrolled: 12 during escalation, 10 in the MTD IV bortezomib cohort and 12 in the MTD SC bortezomib cohort. Patients received a median of 2 prior lines of therapy; 97% bortezomib exposed. With no dose-limiting toxicities, MTD was defined as the maximum planned dose: pomalidomide 4 mg, bortezomib 1.3 mg/m2 and LoDEX. All patients discontinued treatment by data cutoff (2 April 2015). The most common grade 3/4 treatment-emergent adverse events were neutropenia (44%) and thrombocytopenia (26%), which occurred more frequently with IV than SC bortezomib. No grade 3/4 peripheral neuropathy or deep vein thrombosis was reported. Overall response rate was 65%. Median duration of response was 7.4 months. Pomalidomide, bortezomib and LoDEX was well tolerated and effective in lenalidomide-refractory and bortezomib-exposed patients with RRMM.
Automated segmentation of human cervical-supraclavicular adipose tissue in magnetic resonance images
Authors: Lundström Elin , Strand Robin , Forslund Anders , Bergsten Peter , Weghuber Daniel , Ahlström Håkan , Kullberg Joel 
Published: June 2017

AbstractHuman brown adipose tissue (BAT), with a major site in the cervical-supraclavicular depot, is a promising anti-obesity target. This work presents an automated method for segmenting cervical-supraclavicular adipose tissue for enabling time-efficient and objective measurements in large cohort research studies of BAT. Fat fraction (FF) and R2* maps were reconstructed from water-fat magnetic resonance imaging (MRI) of 25 subjects. A multi-atlas approach, based on atlases from nine subjects, was chosen as automated segmentation strategy. A semi-automated reference method was used to validate the automated method in the remaining subjects. Automated segmentations were obtained from a pipeline of preprocessing, affine registration, elastic registration and postprocessing. The automated method was validated with respect to segmentation overlap (Dice similarity coefficient, Dice) and estimations of FF, R2* and segmented volume. Bias in measurement results was also evaluated. Segmentation overlaps of Dice = 0.93 ± 0.03 (mean ± standard deviation) and correlation coefficients of r > 0.99 (P < 0.0001) in FF, R2* and volume estimates, between the methods, were observed. Dice and BMI were positively correlated (r = 0.54, P = 0.03) but no other significant bias was obtained (P ≥ 0.07). The automated method compared well with the reference method and can therefore be suitable for time-efficient and objective measurements in large cohort research studies of BAT.
Association between Carotid Plaque and Cognitive Impairment in Chinese Stroke Population: The SOS-Stroke Study
Authors: Wang Anxin , Liu Xiaoxue , Chen Guojuan , Hao Hongjun , Wang Yongjun , Wang Yilong 
Published: June 2017

AbstractWe aimed to investigate the association between carotid plaques and cognitive impairment among patients with acute ischemic stroke, and to assess key clinical implications. In the Acute Ischemic Stroke Study, patients who received a cognitive testing and underwent complete carotid artery ultrasound scans were included. Cognitive function was measured by the mini-mental state examination. The cross-sectional relationships between cognitive impairment and carotid plaques were evaluated using multivariate logistic regression analysis. Of the 3116 patients included in this study, 826 (26.51%) patients were diagnosed with cognitive impairment. After adjusting for potential confounders, patients with ≥2 carotid plaques (odds ratio [OR] = 1.47; 95% confidence interval [CI]: 1.19–1.82), patients with ≥2 number of carotid arteries with plaque (OR = 1.48; 95% CI: 1.19–1.84) and patients with hypoechoic plaque (OR = 2.05; 95% CI: 1.24–3.38) are more likely to have cognitive impairment. In this acute ischemic stroke population, the number of carotid plaques, the number of carotid arteries with plaque and plaque stability are all associated with cognitive impairment.
Tetraploid embryonic stem cells can contribute to the development of chimeric fetuses and chimeric extraembryonic tissues
Authors: Wen Bingqiang , Li Ruiqi , Cheng Keren , Li Enhong , Zhang Shaopeng , Xiang Jinzhu , Wang Yanliang , Han Jianyong 
Published: June 2017

AbstractOur study examined the in vivo chimeric and survival capacities of chimeras created by injecting tetraploid embryonic stem cells (ESCs) expressing green fluorescent protein (GFP) into diploid embryos. At 3.5 days post-coitum (dpc) and 4.5 dpc, the tetraploid ESCs were able to contribute to the inner cell mass (ICM) just as diploid ESCs tagged with GFP. At 6.5 dpc, 8.0 dpc and 10.5 dpc, the tetraploid ESCs manifested in the same location as the diploid ESCs. The GFP cells in the extraembryonic tissues and fetuses of tetraploid ESC chimeras were tetraploid as determined by fluorescence activated cell sorting (FACS). Furthermore, tetraploid ESCs contributed to the development of the placenta, embryolemma and umbilical cord at 13.5 dpc and 16.5 dpc; however, very less GFP cells were found in the fetuses of tetraploid ESC chimeras. We further found that the proliferation of tetraploid ESCs was slower than that of diploid ESCs. In addition, the relative mRNA expression in the three germ layers and the trophoblast was abnormal in the EBs of tetraploid ESCs compared with diploid ESCs. In short, slower proliferation and abnormal differentiation potential of tetraploid ESCs might be two of the reasons for their poor survival and chimeric capacities.
Optimization of a CRISPR/Cas9-mediated Knock-in Strategy at the Porcine Rosa26 Locus in Porcine Foetal Fibroblasts
Authors: Xie Zicong , Pang Daxin , Wang Kankan , Li Mengjing , Guo Nannan , Yuan Hongming , Li Jianing , Zou Xiaodong , Jiao Huping , Ouyang Hongsheng , Li Zhanjun , Tang Xiaochun 
Published: June 2017

AbstractGenetically modified pigs have important roles in agriculture and biomedicine. However, genome-specific knock-in techniques in pigs are still in their infancy and optimal strategies have not been extensively investigated. In this study, we performed electroporation to introduce a targeting donor vector (a non-linearized vector that did not contain a promoter or selectable marker) into Porcine Foetal Fibroblasts (PFFs) along with a CRISPR/Cas9 vector. After optimization, the efficiency of the EGFP site-specific knock-in could reach up to 29.6% at the pRosa26 locus in PFFs. Next, we used the EGFP reporter PFFs to address two key conditions in the process of achieving transgenic pigs, the limiting dilution method and the strategy to evaluate the safety and feasibility of the knock-in locus. This study demonstrates that we establish an efficient procedures for the exogenous gene knock-in technique and creates a platform to efficiently generate promoter-less and selectable marker-free transgenic PFFs through the CRISPR/Cas9 system. This study should contribute to the generation of promoter-less and selectable marker-free transgenic pigs and it may provide insights into sophisticated site-specific genome engineering techniques for additional species.
Facile Synthesis ZnS/ZnO/Ni(OH)2 Composites Grown on Ni Foam: A Bifunctional Materials for Photocatalysts and Supercapacitors
Authors: Hao Jin , Wang Xiaobing , Liu Fanggang , Han Shuang , Lian Jianshe , Jiang Qing 
Published: June 2017

AbstractA facile one-step hydrothermal reaction was employed to synthesis an integrated bifunctional composite composed by a network structure of ZnS/ZnO/Ni(OH)2 nanosheets with ZnS/ZnO nanospheres in situ growing on Ni foam. The synergistic effect of these three substances make the composite having both improved electrochemical performances and photocatalytic activity. The ZnS/ZnO/Ni(OH)2-4mmol shows a high specific capacitance of 1173.8 F g−1 at 1 A g−1, as well as good rate capability and relatively stable cyclability. Using as photocatalyst, the methyl orange dye in solution can be completely decomposed under ultraviolet-visible radiation in about 80 min. And the composite is easy to be repeatedly used because bulk Ni foam was used as a carrier. Such a bifunctional composite material provides a new insight for energy storage and utilization as well as the water pollution treatment.
Histones H3 and H4 require their relevant amino-tails for efficient nuclear import and replication-coupled chromatin assembly in vivo
Authors: Ejlassi Aïda , Menil-Philippot Vanessa , Galvani Angélique , Thiriet Christophe 
Published: June 2017

AbstractConcomitant chromatin assembly and DNA duplication is essential for cell survival and genome integrity, and requires newly synthesized histones. Although the N-terminal domains of newly synthesized H3 and H4 present critical functions, their requirement for replication-coupled chromatin assembly is controversial. Using the unique capability of the spontaneous internalization of exogenous proteins in Physarum, we showed that H3 and H4 N-tails present critical functions in nuclear import during the S-phase, but are dispensable for assembly into nucleosomes. However, our data revealed that chromatin assembly in the S-phase of complexes presenting ectopic N-terminal domains occurs by a replication-independent mechanism. We found that replication-dependent chromatin assembly requires an H3/H4 complex with the relevant N-tail domains, suggesting a concomitant recognition of the two histone domains by histone chaperones.
Nanorobotic System iTRo for Controllable 1D Micro/nano Material Twisting Test
Authors: Lu Haojian , Shang Wanfeng , Wei Xueyong , Yang Zhan , Fukuda Toshio , Shen Yajing 
Published: June 2017

AbstractIn-situ micro/nano characterization is an indispensable methodology for material research. However, the precise in-situ SEM twisting of 1D material with large range is still challenge for current techniques, mainly due to the testing device’s large size and the misalignment between specimen and the rotation axis. Herein, we propose an in-situ twist test robot (iTRo) to address the above challenges and realize the precise in-situ SEM twisting test for the first time. Firstly, we developed the iTRo and designed a series of control strategies, including assembly error initialization, triple-image alignment (TIA) method for rotation axis alignment, deformation-based contact detection (DCD) method for sample assembly, and switch control for robots cooperation. After that, we chose three typical 1D material, i.e., magnetic microwire Fe74B13Si11C2, glass fiber, and human hair, for twisting test and characterized their properties. The results showed that our approach is able to align the sample to the twisting axis accurately, and it can provide large twisting range, heavy load and high controllability. This work fills the blank of current in-situ mechanical characterization methodologies, which is expected to give significant impact in the fundamental nanomaterial research and practical micro/nano characterization.
High-Throughput Analysis of in-vitro LFP Electrophysiological Signals: A validated workflow/software package
Authors: Tsakanikas P. , Sigalas C. , Rigas P. , Skaliora I. 
Published: June 2017

AbstractSynchronized brain activity in the form of alternating epochs of massive persistent network activity and periods of generalized neural silence, has been extensively studied as a fundamental form of circuit dynamics, important for many cognitive functions including short-term memory, memory consolidation, or attentional modulation. A key element in such studies is the accurate determination of the timing and duration of those network events. The local field potential (LFP) is a particularly attractive method for recording network activity, because it allows for long and stable recordings from multiple sites, allowing researchers to estimate the functional connectivity of local networks. Here, we present a computational method for the automatic detection and quantification of in-vitro LFP events, aiming to overcome the limitations of current approaches (e.g. slow analysis speed, arbitrary threshold-based detection and lack of reproducibility across and within experiments). The developed method is based on the implementation of established signal processing and machine learning approaches, is fully automated and depends solely on the data. In addition, it is fast, highly efficient and reproducible. The performance of the software is compared against semi-manual analysis and validated by verification of prior biological knowledge.