bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of blood flow restriction combined with electrical muscle stimulation on muscle functions and sports performance in male football players with knee osteoarthritis: a randomized controlled trial
Authors: Yang Jinfeng , Li Na , He Sheng , Peng Xiao , Yang Jinqi , Chen Jianxin , Zheng Yan , Zou Yunyan , Liao Yuanpeng 
Published: October 2024

Abstract

The purpose of this study was to investigate the effects of combining BFRT with EMS on muscle functions and sports performance in football players with knee osteoarthritis (KOA). This parallel randomized controlled trial was conducted on 64 football players diagnosed with KOA at Chengdu Sport University. Participants were enrolled based on predefined eligibility criteria and randomly allocated to four groups: the control group (CTR, n = 16), BFRT-alone group (BFRT, n = 16), EMS-alone group (EMS, n = 16), and BFRT combined with EMS group (CMB, n = 16). Data were gathered via the 10-meter sprint, 20-meter sprint, countermovement jump (CMJ), and Illinois agility test (IAT) to assess sports performance. Additionally, peak torque (PT) was used to measure muscle strength, the root mean square (RMS) was used to assess muscle activation, and the cross-sectional area (CSA) was used to evaluate muscle volume. The data were statistically analyzed via SPSS software, and a p-value < 0.05 was considered significant. Following the 8-week intervention, the CMB group exhibited greater improvement in the 10-m sprint compared to the CTR group and demonstrated significant enhancements in the 20-m sprint, CMJ, and IAT, outperforming the other three groups (p < 0.05). To PT, the CMB groups demonstrated significant superiority over the other three groups, while the BFRT group exhibited greater improvement in PT than the EMS group (p < 0.05). Concerning RMS, the EMS and CMB groups showed significant improvements compared with the CTR and BFRT groups, whereas the improvement in the BFRT group was significantly greater than that in the CTR group (p < 0.05). For CSA, the BFRT and CMB groups presented notable advancements compared with the CTR and EMS groups (p < 0.05). In summary, the results suggest that BFRT combined with EMS can increase muscle strength in male football players with KOA through improving muscle volume and neuromuscular recruitment under low-intensity resistance training, thereby increasing explosive power and agility.
A rare case of rhinosporidiosis of the lacrimal sac presenting as a diagnostic dilemma
Authors: Hegde Shruti P , Patil Shwetha , Pattnaik Anshuman , Shekhar Swetank 
Published: October 2024

Abstract

Background
Rhinosporidiosis of the lacrimal sac commonly presents with swelling and epiphora. It is a rare granulomatous infection caused by Rhinosporidium Seeberi and eye along with the adnexa forms the second most common organ of involvement. Most of the reported cases involve the younger age group and are associated with a history of bathing in infested stagnant water.
Case presentation
A 70-year-old lady presented with a slow growing unusually large mass in lacrimal sac area. She was from an urban area and did not give history of bathing in the ponds. She was clinically diagnosed as lacrimal mucocele, managed with dacryocystectomy along with electrocautery intra-operatively and retrospectively diagnosed as rhinosporidiosis with the help of histopathology report.
Conclusion
This case highlights the importance of high suspicion, thorough excision, electrocautery and histopathological examination in all cases of lacrimal sac swellings. Age and classical history may not always be helpful in making proper diagnosis. Also, this is one of the largest lacrimal sac swelling due to rhinosporidiosis that has been reported in literature.
Achieving low radiation dose and contrast agents dose in coronary CT angiography at 60-kVp ultra-low tube voltage
Authors: He Weiling , Huang Feng , Wu Xi , Xie An , Sun Wenjie , Liu Peng , Hu Rui 
Published: October 2024

Abstract

Objectives
To explore the feasibility of a one-beat protocol and ultra-low tube voltage of 60 kVp in coronary CT angiography (CCTA).
Methods
This prospective study enrolled 107 patients (body mass index ≤ 26 kg/m2) undergoing CCTA examinations. Specificially, the conventional group (n = 52) underwent 100 kVp scanning with 45 ml iodine contrast agent and 4 ml/s injection rate, and the low-dose group (n = 55) underwent 60 kVp scanning with 28 ml iodine contrast agent and 2.5 ml/s injection rate. The CT value, signal-noise-ratio (SNR), contrast-noise-ratio (CNR) and subjective image quality score of two groups in aorta (AO), right coronary artery (RCA), left anterior descending (LAD) and left circumflex (LCX) are analyzed in this study. Three types of radiation doses [i.e., volume CT dose index (CTDIvol), dose length product (DLP), effective dose (ED)] of two groups are also compared.
Results
The quantitative results indicated that the low-dose group achieved higher CT values, SNR and CNR results of the AO than the conventional group(P values < 0.001). Both groups had similar CT values, SNR and CNR results in RCA, LAD, and LCX (P values > 0.05). A good agreement is noted with respect to subjective image quality scores in both groups, while the Cohen's kappa value is 0.815 in the low-dose group and 0.825 in conventional group, respectively. In addition, the radiation dose of the low-dose group are significantly lower than the conventional group in terms of CTDIvol, DLP and ED values, and the contrast dose in the low-dose group is also significantly reduced compared to the conventional group(P values < 0.001).
Conclusions
One-beat protocol with a ultra-low tube voltage of 60 kVp could provide improved coronary image quality, reduced radiation dose and reduced iodine contrast dose.
Domestic burning of incense and mosquito coils on the risk of nasopharyngeal carcinoma: Systematic review and meta-analysis
Authors: Xu Jia-Xiu , Tse Lap Ah , Yu Ignatius Tak-sun , Xie Shao-Hua 
Published: October 2024

Abstract

Objectives
To clarify the association between incense and mosquito coils burning and the risk of nasopharyngeal carcinoma (NPC), we performed this systematic review of epidemiological studies.
Methods
A search of studies published through October 2022 in MEDLINE and EMBASE databases was performed, supplemented by searches of reference lists, recent reviews, and Chinese databases. The quality of the included studies was assessed with special reference to exposure assessment. Random-effect meta-analysis estimated the pooled odds ratios (OR) and 95% confidence interval (CI) whenever applicable.
Results
One cohort and 12 case-control studies were identified. The cohort study found no association between incense burning and NPC risk. In meta-analysis of six case-control studies with reasonable quality, the pooled OR for incense burning during adulthood was 1.61 (95% CI 1.43–1.81). Five studies assessed association between exposures to incense smoke during childhood and NPC risk, and the pooled OR was 1.22 (95% CI 0.76–1.96) associated with incense burning at birth and was 1.37 (95% CI 1.10–1.71) for exposure at the age of 10 years. The pooled OR for mosquito coils burning during adulthood was 1.30 (95% CI 1.04–1.62). None of the four previous case-control studies found an increased risk of NPC associated with mosquito coils burning during childhood.
Conclusions
Our findings suggest an increased NPC risk associated with incense burning and mosquito coils. More epidemiological studies with refined exposure assessment are still warranted.
Looking backward at the future of AKI: A retrospective cohort study on the clinic-pathological variables affecting renal recovery after acute kidney injury
Authors: Jose Nisha , Roy Sanjeet , Eapen Jeethu Joseph , Thomas Athul , Johnny Joseph , Raj Selvin Sundar , Varughese Santosh , Alexander Suceena , David Vinoi George , K Reka 
Published: October 2024

Abstract

Introduction: Acute kidney injury (AKI) is no longer considered a single hit disease but part of a spectrum that culminates in adverse renal and cardiovascular outcomes. What are the renal biopsy findings of patient with persistent AKI/AKD (acute kidney disease)? Are there renal biopsy characteristics which predict renal recovery. These are the questions that this study addresses. Methodology: A retrospective study was conducted analyzing all patients who underwent a renal biopsy with a diagnosis of acute kidney injury from January 2021 to January 2023 from the online hospital database. Patients with other glomerular disease and transplant patients were excluded from this cohort. The clinical and renal biopsy characteristics were analyzed for their correlation with renal recovery. Results: Of 420 patients screened, 54 were included in the study. Most patients had stage 3 AKI. The median follow up in this study was 80.50 days. Among those on dialysis, 55.6% of patients became free of KRT (kidney replacement therapy). 92.6% of the study population had diffuse tubular involvement on the renal biopsy. Clinical recovery correlated with the degree of vasculature involvement on the renal biopsy. Interstitial fibrosis and tubular atrophy corelated with progression to CKD. Among the clinical features, the cause of AKI, presence of pre-existing CKD and Charleston co-morbidity score correlated with independence from KRT. Conclusion: Specific findings on the renal biopsy such as atherosclerotic changes correlate negatively with long-term recovery in AKI and renal biopsy findings of interstitial fibrosis and tubular atrophy may help to prognosticate progression to CKD.. Among clinical characteristics, the presence of co-morbidities and pre-existing CKD correlates negatively with renal recovery.
Endothelial function in high-risk patients with ezetimibe therapy
Authors: Günes-Altan Merve , Bosch Agnes , Striepe Kristina , Schiffer Mario , Achenbach Stephan , Schmieder Roland E. , Kannenkeril Dennis 
Published: October 2024

Abstract

Background
Impaired endothelial function predicts cardiovascular (CV) events, especially in patients with established CV disease. The aim of this post hoc analysis was to compare the endothelial function between high-risk patients on optimized statin therapy with and without additional ezetimibe treatment.
Methods
A total of 91 patients with CV and statin treatment (Atorvastatin or Rosuvastatin) were included and underwent examination of endothelial function by the UNEX EF device. Endothelial function parameters were compared between patients with (E + group) and without ezetimibe therapy (E- group) (NCT03626831).
Results
Compared to patients in the E- group (n = 70), patients in the E + group (n = 21) were younger (67.0 ± 7.4 versus 61.2 ± 7.2 years; p = 0.002), had lower low density lipoprotein cholesterol (91.2 ± 13.3 versus 102.0 ± 18.1 mg/dl (p = 0.013) and lower office systolic blood pressure (123.9 ± 11.4 versus 130.2 ± 14.5 mmHg (p = 0.042). High sensitive C-reactive protein (hsCRP) was lower in the E + group than in the E- group (0.5 ± 0.4 versus 1.1 ± 0.9 mg/L; p = 0.037). We found a greater flow-mediated vasodilation (6.1 ± 2.0 versus 3.7 ± 3.2%; p = 0.004) and lower brachial intima-media thickness (0.28 ± 0.1 versus 0.32 ± 0.0 mm; p = 0.011) in the E + group compared to the E- group. When confounders were entered in a covariance analysis, differences of FMD (p = 0.034) and hsCRP (p = 0.049) between the groups remained significant.
Conclusion
Our data indicate that endothelial function is better in high-risk patients with preexisting CV disease treated with ezetimibe along with statin than in patients with statin monotherapy.
Trial registration Number:
NCT03626831
Date of registration: 2018-08-08
Autologous stem cell transplantation from 2000 to 2022 in Japanese patients aged ≥65 years with relapsed or refractory diffuse large B-cell lymphoma
Authors: Yamasaki Satoshi , Mizuno Shohei , Yoshifuji Kota , Matsuki Eri , Sawa Masashi , Akasaka Takashi , Uchida Naoyuki , Uchiyama Hitoji , Kataoka Keisuke , Hiramoto Nobuhiro , Kanda Yoshinobu , Ishiwata Kazuya , Wakayama Toshio , Fukuda Takahiro , Yoshimitsu Makoto , Onizuka Makoto , Ohbiki Marie , Atsuta Yoshiko , Suzuki Ritsuro , Kako Shinichi 
Published: October 2024

Abstract

High-dose chemotherapy with autologous stem cell transplantation (ASCT) is an option for patients aged ≥ 65 years with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Few data are available to select patients suitable for chimeric antigen receptor T-cell (CAR-T) therapy or bispecific antibodies. We retrospectively analyzed the risk factors for poor outcomes for 575 Japanese patients aged ≥ 65 years with R/R DLBCL who received ASCT at either second complete remission or first partial remission between 2000 and 2010 (n = 82 and 42) or 2011 and 2022 (n = 336 and 115), respectively. CAR-T became commercially available in Japan in March 2019, and the annual number of ASCTs for older patients with R/R DLBCL increased significantly until 2018. However, the number of ASCT cases plateaued in 2018. Multivariate Cox regression analysis identified performance status of 0 at ASCT and receiving ASCT after 2011 as independent predictors of overall survival and an association with late recurrence and better progression-free survival. CAR-T therapy or bispecific antibodies may be used initially instead of ASCT for early relapsed and refractory patients. ASCT remains beneficial for older chemo-sensitive patients with late recurrence and good performance status at ASCT.
Advanced Lung Cancer Inflammation Index ： A Key Predictor of Hepatic Steatosis and Fibrosis Severity
Authors: Master Yajie LIU , WANG Ruilin 
Published: October 2024

Abstract

Background
Inflammation and nutrition are crucial pathogenic mechanisms in Non-alcoholic fatty liver disease (NAFLD). The Advanced Lung Cancer Inflammation Index (ALI) effectively reflects the systemic inflammation level and nutritional metabolic status of patients. However, its relationship with hepatic steatosis and hepatic fibrosis remains unclear. The study aimed to provide novel insights into the prevention of hepatic steatosis and hepatic fibrosis by examining the relationship between the ALI and Controlled Attenuation Parameter (CAP) and Liver Stiffness Measurement (LSM).
Methods
To identify the connection between ALI and hepatic steatosis and hepatic fibrosis, this study utilized descriptive analysis, multivariate linear regression, smooth curve fitting, and threshold effect analysis to investigate data from the National Health and Nutrition Examination Survey conducted in 2017–2020.
Results
The ALI levels in the NAFLD and Advanced liver fibrosis (AHF) groups were considerably elevated than the control group, with statistical significance (NAFLD: 70.980 vs. 58.680, P < 0.001; AHF: 72.420 vs. 63.360, P < 0.001). Multiple linear regression analyses indicated significant positive associations between ALI and its quartiles with both CAP and LSM levels. There was a positive smooth curve fitting relationship between ALI and the levels of CAP and LSM, with threshold effect inflection points at 88.287 and 98.420, respectively.
Conclusion
The findings suggest a positive correlation between elevated ALI levels and the levels of CAP and LSM. Maintaining ALI within an appropriate range may help mitigate the prevalence of hepatic steatosis and hepatic fibrosis.
Bronchial Artery Pseudoaneurysm Presenting with Hemoptysis and Hemothorax after Pulmonary Lobectomy: A Case Report and Literature Review
Authors: Zhang Weihao , Jin Chengyan , Qi Xiao , Zhang Guangxin , Tong Ti 
Published: October 2024

Abstract

Background: Bronchial artery pseudoaneurysm is a rare vascular disorder, and cases of bronchial pseudoaneurysms reported after lung surgery are even rarer. The number of reported cases is very limited due to the unclear pathogenesis, lack of diagnostic criteria and treatment guidelines, and nonspecific clinical manifestations.
Case presentation: The paper reports a case of a patient with primary lung adenocarcinoma who developed hemoptysis, chest and back pain, and right hemothorax after lobectomy. Due to the lack of experience in treatment, we suspected that the above symptoms were caused by postoperative bronchovascular fistula. The second thoracotomy and bronchoscopydid not reveal any obvious hemorrhage or fistula, and a subsequent bronchial arteriography confirmed the presence of a pseudoaneurysm in the right main bronchial artery. Later, the patient underwent transcatheter bronchial artery embolization and was followed up for half of a year after the operation without experiencing any of the previously mentioned symptoms.
Conclusion: The case reports the successful cure of bronchial artery pseudoaneurysm after pulmonary lobectomy through bronchial artery embolization.
Global, regional, and national burdens of blindness and vision loss attributable to diabetes from 1990 to 2021, and forecasts to 2045: analysis from the Global Burden of Disease Study 2021
Authors: Ye Lingxia , Huang Xin , Xu Yufeng 
Published: October 2024

Abstract

Background
Blindness and vision loss (BVL) is a major public health concern. Diabetes is associated with a series of vision loss causes. An understanding of the trend of the burden of BVL attributable to diabetes is critical for planning health policy.
Methods
We obtained global, regional, national, age- and sex-specific data on the prevalence and years lived with disability (YLDs) of BVL attributable to diabetes mellitus from the Global Burden of Disease Study 2021 (GBD 2021) and performed a secondary comparative analysis by time, location, SDI, age, gender and severity.
Results
From 1990 to 2021, the global incidence and age-standardized rate of BVL continuously increased. In 2021, 5836.5 thousand BVL cases attributable to diabetes occurred globally, and the age‐standardized rate for YLDs was 67.3 per 100,000 population. Great disparities were found across different genders, ages, and locations. Higher burdens appeared in females, elderly individuals, and regions with less advanced health systems.
Conclusions
The burden of BVLs attributable to diabetes has increased significantly since 1990 and varies widely across regions. Greater efforts are needed in diabetes control and vision protection, especially in elderly individuals and females, in regions with middle and low-middle SDI regions, and in regions with less advanced health systems.
The Role of Endoscopic Ultrasound in Detecting Common Bile Duct Stones Missed Post-Endoscopic Retrograde Cholangiopancreatography in Patients with Calculous Obstructive Jaundice
Authors: Hassan Mohamed Badr , Hashim Ahmed Morad , darwish Mahmoud Abd Elnabi Mohamed , Abdellatef Abeer 
Published: October 2024

Abstract

Background
Choledocholithiasis occurs in up to 20% of patients with gallstones. Diagnosing choledocholithiasis can be challenging. Previously, the gold standard for diagnosis was endoscopic retrograde cholangiopancreatography (ERCP). However, small stones often evade detection through ERCP and magnetic resonance cholangiopancreatography (MRCP). Endoscopic ultrasound (EUS) has proven effective in identifying common bile duct (CBD) stones that MRCP and ERCP might miss, particularly small stones or those lodged in the distal CBD or papillary region. The study aimed to evaluate the accuracy of EUS in detecting CBD stones missed by MRCP and ERCP.
Methods
A case-control study was conducted; we enrolled 30 patients who were presented with calculous obstructive jaundice and had undergone both ERCP and MRCP. A stent was inserted in these patients. Prior to stent removal, these patients underwent EUS to evaluate its effectiveness in detecting any remaining CBD stones post-ERCP. The sensitivity and specificity of EUS, ERCP, and MRCP were compared based on the presence, size, and number of detected stones.
Results
The mean age of involved patients was 50.3 ± 10.2 years. ERCP demonstrated a sensitivity of 44.4%, specificity of 100%, positive predictive value (PPV) of 100%, negative predictive value (NPV) of 16.6%, and an accuracy of 50%. MRCP showed a sensitivity of 81.5%, specificity of 100%, PPV of 100%, NPV of 37.5%, and an accuracy of 83.3% when compared to EUS results. The complication rate for EUS was significantly lower than that for diagnostic ERCP. Additionally, an EUS-based strategy was more cost-effective than diagnostic ERCP for patients with low, moderate, or intermediate risk.
Conclusion
Endoscopic ultrasound (EUS) is a promising, non-invasive, non-contrast technique that may serve as a superior diagnostic tool compared to MRCP and ERCP, particularly for detecting small stones or those impacted in the distal CBD or papillary region.
Streptococcus Suis Infective Endocarditis in Patients With Streptococcus Suis Septicemia : A Retrospective Study of Prevalence and Outcomes
Authors: Kedsawadevong Pongsira , Jamnongprasatporn Sirichai , Ratanasit Nithima 
Published: October 2024

Abstract

Background
Streptococcus suis (S. suis) is a zoonotic disease that transmits to humans by contact or oral route. Although the major clinical presentation of this pathogen has been known as meningitis, S. suis infective endocarditis (IE) has recently emerged as a field of interest. However, echocardiography is underutilized in patients with S. suis septicemia.
Objective
The primary objective was to study the prevalence of S. suis IE in patients with S. suis septicemia. The secondary objective was to assess the predictors, echocardiographic features, and clinical outcomes.
Materials and method
The authors conducted a single-center retrospective study. The patients who were older than 18 years and admitted to Siriraj Hospital due to S. suis septicemia between January 2007 and September 2023 were included. Prevalence was defined as a percent and confidence interval (CI). Univariable and multivariable analyses were performed to determine the predictors of S. suis IE. Baseline characteristics and clinical outcomes of patients with and without IE were compared. A p-value < 0.05 was defined as statistically significant.
Result
A total of 71 patients with S. suis septicemia were included in the study. The prevalence of S. suis IE was 26.8% (95%CI 17.85 to 38.05) and heart failure was an independent predictor of IE. Perivalvular complications and significant valvular regurgitation were found in 52.6% and 80%, respectively. 13 out of 19 patients (68.4%) required valvular surgery according to standard guidelines.
Conclusion
The present study reveals a sizable proportion of S. suis IE in patients with S. suis septicemia, in conjunction with a high rate of valvular damage and perivalvular complications. Therefore, echocardiography should be considered in patients with S. suis septicemia, especially with a heart failure presentation. Further reclassification of this pathogen as a “typical” organism should be deliberated.