bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical composition, antimicrobial, antioxidant, and wound healing activities of Thermopsis turcica
Authors: Akdağ Gülçin , Hazman Ömer , Aksoy Laçine , Savrık Mehmet , Büyükben Ahmet , Yılmaz Mustafa Abdullah , Cakir Oguz , Kara Recep 
Published: October 2024

Abstract
The antioxidant, antimicrobial, anticarcinogenic, wound healing activities and phenolic substance profile of aqueous extracts prepared using branch, leaf, flower parts and above-ground parts of Thermopsis turcica were determined in the study. The analyses indicate that the total phenolic substance contents and total antioxidant status are higher in the mix, flower, and leaf extracts. The extracts reduced cell viability in HGF cells more than in A549 cells. It shows that the extract has low anticarcinogenic activity in A549 cells. Flower extract had the highest wound closure rate. Quinic acid, cyranoside and luteolin were found in high concentrations in all extracts with LC/ESI-MS/LC analysis. It has been determined that the flower extract of the species is the most critical part showing antioxidant, antimicrobial, cytotoxic and wound healing properties. While the leaf and mix extracts stand out with their antioxidative and antimicrobial properties, the branch extract is effective in wound healing.
Confusion in the interpretation of prolactin levels caused by inappropriately low reference intervals
Authors: Sabogal Piñeros Yanaika S , Deckers Martine M L , de Bie Prim , Heijboer Annemieke C , Hillebrand Jacquelien J 
Published: October 2024

Objective
Serum prolactin measurements are important in the differential diagnosis of pituitary masses and subfertility. We observed discrepancies in serum prolactin levels in several patients measured with different immunoassays. Despite differences in assay results, the reference intervals (RIs) derived by the manufacturers were similar. In this study, we aimed to investigate prolactin assay differences and to re-establish RIs for different prolactin immunoassays.

Methods
For the assay comparison, serum samples were collected from men and women visiting the Amsterdam UMC hospital. Prolactin levels were measured using the AtellicaTM IM analyzer (Siemens Healthineers) and the Cobas (Roche Diagnostics) immunoassay. RIs for prolactin were re-established for men, premenopausal women, and postmenopausal women for both the Atellica and Cobas immunoassay.

Results
Prolactin levels measured using the Cobas immunoassay were 1.75 times higher than those measured using the Atellica immunoassay. The re-established RIs for Atellica and Cobas confirmed these findings and were <0.32 U/L; <0.55 U/L for men; <0.64 U/L; <0.86 U/L for premenopausal women, and <0.31 U/L; <0.59 U/L for postmenopausal women, respectively, for Atellica and Cobas assays. The re-established RIs of the Atellica assay matched the current and manufacturer RIs, whereas those for Cobas differed substantially.

Conclusions
Prolactin levels are assay-dependent, and the re-established RIs are different for the Atellica and Cobas assays. We recommend that laboratory specialists and manufacturers periodically review prolactin assay RIs, as incorrect RIs can lead to misinterpretation of prolactin levels and unnecessary referrals and further laboratory testing, as we have experienced.

Plain language summary
We showed that the results of different prolactin tests disagree by 75%, which hinders correct interpretation. Thus, we established test-specific prolactin normal values. By being aware of test differences and using test-specific normal values, one can ensure correct interpretation and prevent unnecessary referrals and concern.
The Use of Dynamic Navigation for the Placement of Zygoma Implants. A Cadaver Study to Compare Accuracy
Authors: Bishbish Omran , Kim Yoon Jeong , Kan Joseph , Lozada Jaime 
Published: October 2024

ABSTRACT

Objective:
This study aimed to compare the angular, platform, and apical deviation of zygoma implants placed with the aid of a dynamic navigation device compared to the implants placed freehand.

Methods:
Eight cadaver heads were used for the study. Pre-operative CBCT scans were made for the heads, and an implant planning software was used to plan zygoma implants bilaterally in each scanned head. A total of 16 zygoma implants were placed using each surgical technique. Post-implant CBCT scans were merged with the pre-operative plan to evaluate and compare the accuracy of the implants using each technique. Angular and linear deviations of the implants were measured and compared. The effect of implant length and position on the deviation was also investigated.

Results:
The results showed a mean angular deviation of 2.44 ± 1.10 degrees for implants placed using DN compared to 6.63 ± 4.81degrees for implants placed freehand. The mean apical deviation for implants placed using DN and for implants placed freehand was 2.14 ± 1.02 mm and 3.80 ± 2.49 mm, respectively. Finally, the mean platform deviation for implants placed using DN and for implants placed freehand was 1.66 ± 0.9 mm and 2.81 ± 2.1 mm, respectively. The analysis showed a significant difference between the two angular and apical deviation techniques. ( p=0.001 and 0.029 respectively).

Conclusion:
Zygoma implants placed with a dynamic navigation device resulted in less apical and angular deviation than implants placed freehand..
E5-((3-phenoxyphenyl)diazenyl)quinolin-8-ol (PPDQ) : A Novel Promising Anticorrosive for Mild Steel in Acid Media, and a Pharmacologically Potent Antidiabetic, Antioxidant Azo Dye
Authors: K Pruthviraj , B. S Chethan , H. Ramesh , N. K. Lokanath , P. C. Kiran Poral , K. S. Devaraju , N. Narayana Hebbar , K. Sunil 
Published: October 2024

A novel quinoline based azo dye 5-((3-phenoxyphenyl)diazenyl)quinolin-8-ol (PPDQ) was synthesized using conventional one pot MCR pathway and its structure has been confirmed by multinuclear (1H & 13C) and mass spectral techniques. PPDQ subjected for remarkable analytical applications like anticorrosion potential for mild steel in acidic media. Further, the experimental results were compared with that of the theoretical DFT based calculations and found to be in good agreement with each other. To evaluate the pharmacological activity of the compound invitro antidiabetic and antioxidant activity were carried out. The corrosion inhibition potential of the PPDQ was explored using electrochemical method which exhibited maximum corrosion inhibition efficiency up to 77% on mild steel in 1 M HCl media, further the anticorrosion potential was confirmed by quantum chemical calculations (DFT, ESP diagrams). Antidiabetic activity and antioxidant potency was evaluated using DPPH, and ABTS radical scavenging assay. Further, the in-vitro values were compared with insilico molecular docking studies.
Seismometer Orientation Measurements of Broadband Seismic Stations in the China Digital Seismograph Network
Authors: Deng Wenze , Han Guangjie , Li Juan , Sun Li 
Published: October 2024

ABSTRACT
The China Digital Seismograph Network, one of the largest national seismic networks, has been operating for over four decades which provides valuable seismic data for various scientific studies. Our investigation gathered a comprehensive dataset comprising 5,456,816 three-component waveforms from 3187 seismic events that took place over nine years (2014–2022). We assessed sensor orientations at 1056 broadband stations using the P-wave polarization method. Together with our calculation results, operation and maintenance log of regional networks, on-site checking, and manual inspection, we identified and addressed issues related to temporal changes of orientation, polarity reversal, and channel mislabeling. We found that ∼65.8% of seismometers (694) were well aligned with the absolute misorientation angle ≤3°, 20.8% of seismometers (220) were fairly well aligned with the absolute misorientation angle lying between 3° and 10°, 3.6% (38) of seismometers were misaligned exceeding 10°, and 9.8% of seismometers (104) showed a temporal variation in alignment. The fairly high consistency between our numerical results and gyrocompass measurements confirms the reliability of our investigation. We further compared the results of P-wave receiver functions analysis before and after sensor orientation correction. The findings indicate that sensor misorientation angles may lead to inaccurate and unstable seismological results. Therefore, conducting a systematic assessment, diagnosis, and correction for sensor orientation would be beneficial for advancing seismological analysis by promoting consistency, efficiency, accuracy, collaboration, reproducibility, and adaptability in data processing and interpretation.
Metabolic and histopathological impact of local resource food consumption on blood markers in rats previously subjected to moderate acute malnutrition
Authors: Kouadio Natia Joseph , Kouadio Ange Laetitia Jocelyne , Assoumou Carine Ebah , Kra Aboutou Severin Kouassi 
Published: October 2024

Malnutrition is caused by dietary and nutritional imbalances that can have an impact on blood parameters and vital organs. The use of local agricultural resources for adapted diets appears to be an effective solution to post-weaning infant malnutrition. The aim of this study was to evaluate the effectiveness of four newborn diets made from local agricultural resources in improving biochemical, hematological, and histological parameters in rats that had previously experienced mild acute malnutrition. A total of 42 juvenile male rats, with an average age of 80 ±5 days and an average weight of 103.46 ± 5.10 g, were divided into six groups. Each group consisted of seven rats, with two control groups (LTC and LSA) and four experimental groups (LAR1A, LAR1B, LAR2A, and LAR2B). The experiment had three distinct phases: an initial adaptation period lasting 5 days, followed by a phase of inducing malnutrition lasting 19 days, and finally a phase of nutritional rehabilitation lasting 14 days. At the conclusion of the malnutrition induction and nutritional rehabilitation phases, blood samples were collected and used to evaluate biochemical and haematological markers. Kidneys and liver were removed for histological analysis.The findings revealed that the period of inducing malnutrition had a detrimental impact on several parameters, such as urea, triglyceride, total protein, C-reactive protein, albumin, ALAT, ASAT, WBC, hemoglobin, hematocrit, and MCV. Nevertheless, the ingestion of LAR diet derived from indigenous ingredients successfully returned all of these blood markers to the required levels for rats. Furthermore, histological examinations demonstrated that there were no kidney or liver abnormalities at the end of the trial.The LAR diets have rehabilitative effects on the biochemical and haematological parameters of rats. This suggests that these diets can be used therapeutically to treat moderate acute malnutrition and meet the nutritional needs of children aged 6 to 36 months.
Los conflictos de agencia en las asociaciones: apuntes sobre la deficiente regulación del Código Civil sobre los deberes y obligaciones de los administradores de personas jurídicas no lucrativas
Authors: Chahud Cosío Daniel 
Published: October 2024

La teoría de la agencia se dedica al análisis de la relación entre el ‘principal’ y el ‘agente’, así como los conflictos que surgen de su interacción y de sus diversos intereses. Sin embargo, los conflictos de agencia no solo son posibles en personas jurídicas no lucrativas como las asociaciones, sino que serían más frecuentes debido a su naturaleza. En este sentido, el presente trabajo examina el papel de los órganos de administración de las asociaciones civiles en relación con los posibles conflictos entre los asociados y los administradores, y la insuficiente regulación que los rodea.Dado que no todos los individuos que participan en actividades empresariales bajo una estructura asociativa tienen un entendimiento completo del gobierno corporativo, el autor señala que es crucial que nuestra legislación sirva como una guía para facilitar su participación y, en consecuencia, reducir la posibilidad de conflictos entre los diferentes grupos implicados.
La solución al conflicto entre las facetas del derecho a conocer a los padres y a ser cuidado por ellos: ¿biparentalidad o multiparentalidad?
Authors: Plácido Vilcachagua Alex 
Published: October 2024

Este artículo examina diez sentencias de casación de la Corte Suprema de Justicia del Perú, mostrando una preferencia por la biparentalidad en disputas de paternidad. Las decisiones privilegian la identidad estática del niño, basada en su derecho a conocer a sus padres biológicos según la ‘Convención sobre los Derechos del Niño’.A pesar del reconocimiento ocasional de la identidad dinámica, la multiparentalidad no ha sido considerada por los tribunales. Los criterios de decisión incluyen la prueba de ADN y la posesión de estado de familia.El artículo recomienda que el Poder Judicial peruano contemple la multiparentalidad como una extensión del derecho a la identidad y la responsabilidad parental, proponiendo su formalización en el registro civil para beneficiar el interés superior del niño.
La parábola de la viuda pobre: en defensa de la lesión en el derecho de los contratos
Authors: Núñez del Prado Chaves Fabio 
Published: October 2024

La lesión en el derecho de los contratos es una figura que no ha sido ajena a críticas que cuestionan su relevancia y utilidad en el ordenamiento jurídico peruano.En esa línea, en el presente trabajo el autor analiza el artículo 1447 del Código Civil desde distintas aristas, tales como el análisis económico del derecho y diversa doctrina nacional e internacional.Finalmente, el autor concluye que esta figura es importante y necesaria para un Estado de Derecho; no sin antes reconocer que la lesión en el derecho de los contratos debe ser repensada, mas no eliminada.
El uso de los principios UNIDROIT para interpretar y complementar el derecho contractual nacional: un modelo para el legislador peruano
Authors: García Long Sergio 
Published: October 2024

En 2024, el Código Civil peruano cumple 40 años desde su promulgación en 1984, mientras que los Principios UNIDROIT cumplen 30 años desde su primera versión en 1994. Ante ello, ¿a qué fiesta debemos asistir? Este ensayo propone una mirada del Código Civil peruano desde la perspectiva del comercio internacional, con el objetivo de proponer mejoras. Para ello, se toma como referencia las disposiciones de los Principios UNIDROIT que regulan la interpretación contractual, las obligaciones de medios y resultados, la cláusula penal y la fuerza mayor. Estas disposiciones serán comparadas con las del Código Civil peruano, para identificar posibles áreas de mejora en el derecho doméstico, utilizando los Principios UNIDROIT como guía.
Sobre los 40 años del Código Civil: una mirada histórica
Authors: Vidal Ramírez Fernando 
Published: October 2024

En marco del aniversario número cuarenta del Código Civil, el Dr. Vidal Ramírez, uno de los pocos miembros de la Comisión Reformadora del Código Civil aún en vida, nos cuenta historias inéditas acerca de la experiencia de reforma y proceso de codificación del Código Civil de 1984.Asimismo, rememora a los demás miembros de la Comisión Reformadora, así como los retos y desafíos a los que se enfrentaron para lograr lo que hoy en día puede considerarse como la norma civil más importante en nuestro medio.
Nonsteroidal anti-inflammatory drug administration to periparturient cows to reduce postpartum pain-related behaviours
Authors: Cannadine Amelia 
Published: October 2024

Question
In periparturient cows does the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) aid in reducing pain-related behaviours after parturition when compared to cows not administered NSAIDs?

Clinical bottom line
The category of research question was:
Treatment.

The number and type of study designs that were critically appraised were:
Four randomised control trials.

Critical appraisal of the selected papers meeting the inclusion criteria collectively provide zero/weak/moderate/strong evidence in terms of their experimental design and implementation:
Moderate.

The outcomes reported are summarised as follows…
The evidence suggests that NSAIDs can reduce some pain-related behaviours and increase resting behaviours in postpartum cows, with the effect being most consistently observed when administered between 6 and 48 hours before calving or within 3 hours after calving. This effect was most consistently observed in individuals that had experienced uncomplicated calving events and primiparous animals. Primiparous animals administered meloxicam prior to natural calving displayed significantly more lying bouts on the day of calving when compared to primiparous control animals and primiparous animals administered meloxicam postpartum. A separate study reported that cows administered ketoprofen spent less time in lateral recumbency than cows in the placebo group, irrespective of whether calving was assisted. Additionally, when treatment cows were in sternal recumbency, they spent more time with their head in a rested position than the placebo group. There was no significant difference in feeding behaviours postpartum between treatment and placebo animals. There were conflicting results between papers assessing activity levels.

In view of the strength of evidence and the outcomes from the studies the following conclusion is made…
In some cows, in particular cows with an uncomplicated parturition, NSAIDs can reduce some pain-related behaviours and increase some resting behaviours postpartum. The NSAID should be administered between 6 and 48 hours before calving or within 3 hours after calving.
Nuchal Ligament Reconstruction Surgery for Dropped Head Syndrome
Authors: Endo Kenji , Kanai Hiroshi , Sawaji Yasunobu , Aihara Takato , Suzuki Hidekazu , Konishi Takamitsu , Nishimura Hirosuke , Yamamoto Kengo 
Published: October 2024

Case:
An 86-year-old woman suffered from dropped head syndrome (DHS). As she was not willing to undergo fusion surgery, we proposed a novel nuchal ligament reconstruction surgery, which is not a direct correction of the malalignment but rather a recovery of the function of extensor muscles under local anesthesia. Twelve months after surgery, the patient remains satisfied and is able to maintain a horizontal gaze.

Conclusion:
This is the first report regarding a less invasive nuchal ligament reconstruction surgery successfully performed for DHS.
Development of System for Underbalanced Drilling Offshore, Approach for Planning and Execution
Authors: Nessa Dag Oluf , Tangedahl Michael J. , Saponja Jeff 
Published: October 2024

Abstract
Being one of the major actors in the oil and gas contracting industry, we have acknowledged and recognized the underbalanced drilling technology and the interest created for its implementation. Together with North-American interests we have been working jointly in developing the onshore system to accomplish operations offshore with system introduction from platforms, jack-ups and semi-submersible vessels. The concept is based on the use of jointed pipe operations from existing rigs or by workover rigs, but does as well include working with coiled tubing and snubbing units.
Lactobacillus rhamnosus GG affects spaceflight-induced helper T cell disorder by modulating the gut microbiota and microbial-derived metabolites
Authors: Liu Zizhong , Luo Gui , Li Yixuan , Du Ruikai , Cui Ying , Zhang Hanwen , Li Jianwei , Zhong Guohui , Sun Weijia , Li Yuheng , Xing Wenjuan , Zhao Dingsheng , Yuan Xinxin , Jin Xiaoyan , Ling Shukuan , Han Yanping , Li Yingxian 
Published: October 2024

Abstract

Spaceflight is physically demanding and has negative effects on the health of astronauts. Previous studies demonstrated that the human gut microbiota and immunity were affected by spaceflight and simulated spaceflight. Changes in the abundance of beneficial taxa might influence immunity by disrupting the microbiome network balance. This study investigated the effects of Lactobacillus rhamnosus GG (LGG) on simulated spaceflight-induced helper T cell disorder in hindlimb unloading (HU) mice. Helper T cell ratios in control mice were affected by transplantation of the fecal microbiota from HU mice, and the abundance of LGG in the gut microbiota was affected by both true and simulated spaceflight. The gut microbiota composition, fecal metabolites, and helper T cell ratios were markedly affected by LGG in HU mice, and there was a correlation between helper T cell ratios and gut microbial-derived short-chain fatty acids (SCFAs). Our findings indicate that spaceflight adversely affects helper T cell ratios, and demonstrates that LGG impacts simulated spaceflight-induced helper T cell disorder by modulating microbial-derived SCFAs.
WITHDRAWN: Optimized Cost Estimation in Software Project Planning using Fuzzy Logic and Genetic Algorithm
Authors: Jaiswal Ajay , Raikwal Jagdish , Raikwal Pushpa 
Published: October 2024

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
The Effect of a Portative Glass Waterfall and a White Noise App On Pain, Anxiety, and Physiological Parameters During Gastroscopy Procedure: A Double Blind Randomized Clinical Trial
Authors: GENÇ Hasan , TANRIVERDİ Seher 
Published: October 2024

Abstract

Background
The procedure of gastroscopy is a difficult and stressful method of diagnosis and treatment for the patient. The test can cause an unpleasant sensation of pain as it passes through the mouth and throat. The aim of this study was to investigate the effect of a Portative Glass Waterfall (PGW), which is an artificial natural waterfall device, and a White Noise (WN) mobile application on patient pain, anxiety, and physiological parameters during gastroscopy procedure
Methods
This study was a double blind randomized clinical trial. The study was completed with a total of 135 participants, 45 in the PGW group, 45 in the WN group, and 45 in the control group. Data were collected using a Patient Information Form, a Physiological Parameters Record Form and a Visual Analog Scale to assess pain, and the State-Trait Anxiety Inventory.
Results
The results of study showed that there were significant decreases in pain, anxiety, heart rate, systolic and diastolic blood pressures and significant increases in respiratory rate, and oxygen saturation levels in both PGW and WN groups (p < .05). In the control group, no significant difference was found between the means of the variables before and after the procedure (p > .05).
Conclusion
According to the results of the study, PGW and WN applied during the gastroscopy procedure decreased pain and anxiety in patients and had a positive effect on physiological parameters.
Trial registration
: ClinicalTrials.gov Identifier NCT06333431 Registration date: 13.03.2024.