bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Eugenol Loaded Chitosan Nanoparticles on Sepsis Induced Liver Injury in Rats
Authors: Ali Qutb Sarah , Mahmoud Soliman Amel , Ramadan Fahmy Sohair , Saber Mohamed Ayman 
Published: October 2024

Background:
Sepsis is a life-threatening condition responsible for high morbidity
and mortality rates around the world and is characterized by a dysregulated host response to
infection, resulting in multiple organ dysfunctions. Eugenol is a phenolic aromatic compound
derived from clove oil. It has anti-inflammatory, antioxidant, antibacterial, antiviral, antifungal,
and anticancer characteristics, which have led to its extensive use in diverse fields, including
cosmetology, medicine, and pharmacology. The ongoing study aimed to evaluate the efficacy of
eugenol-loaded chitosan nanoparticles (EC-NPs) on sepsis-induced liver damage using the cecal
ligation and puncture (CLP) model.

Methods:
Thirty male albino rats were randomly divided into five groups: Sham, sepsis, and
septic rats treated with chitosan, eugenol, or EC-NPs.

Results:
EC-NPs showed excellent antibacterial, antioxidant, and anti-inflammatory effects in
vitro. EC-NP administration significantly improved liver function, as indicated by the decreased
liver enzyme activities and C-reactive protein (CRP) level, as well as the increase of albumin
content. Moreover, EC-NPs caused an increase in glutathione-reduced and antioxidant enzyme
activities, as well as a reduction of malondialdehyde and nitric oxide formation. In addition, the
EC-NP treatment reduced the DNA damage in septic rats; also, the EC-NP treatment repaired,
to some extent, the abnormal architecture of the hepatic tissues of septic rats. Furthermore, the
immunohistochemical examination showed a marked decrease in inflammation through the reduction
of TNF-α and IL-1β expression.

Conclusion:
In conclusion, EC-NPs attenuated liver injury in sepsis through its antiinflammatory,
anti-bacterial, and anti-oxidant activities and protection of DNA.
Correlation between screen time and physical activity to student’s physical fitness
Authors: Prakoso Anang Bagus , Arief Nur Ahmad , Muin Abd , Wardani Nurul Kusuma 
Published: October 2024

The development of electronic media may increase screen time (ST) duration, cause students to develop sedentary habits, and decrease their physical activity (PA). Lately, this has been thought to be the cause of the problem of low physical fitness (PF) among students. This study aimed to analyze the correlation between screen time, physical activity, and students' physical fitness. The design of this study was correlational, with a total of 88 subjects in grades 4 and 5 at Primary Laboratoy School (Labschool) Unesa 1. The sampling technique was simple random sampling. Nusantara students' physical fitness test (TKPN) was employed to assessed physical fitness, screen time-based sedentary behaviour questionnaire to assessed sedentary behaviour, and physical activity questionnaires for older children to assessed physical activity level. Data were collected in alignment with the physical education schedule for each class. Multinomial logistic regression was employed for data analysis. Findings revealed a significant simultaneous correlation among sedentary time (ST), physical activity (PA), and physical fitness (PF) (p = 0.017). However, partial analysis indicated no significant correlation between ST and PF (p = 0.517), while PA demonstrated a significant correlation with PF (p = 0.013). The results of the descriptive analysis showed that 73.9% of participants had very poor levels of physical fitness, and 43.18% of participants had low physical activity levels, with an average daily screen time duration of 3.03 hours. Participants accessed electronic media mostly to play games on smartphones, with an average of 2.28 hours. This study concluded that screen time was not directly affecting physical fitness but could reduce physical activity and student fitness. Despite screen time having no direct impact on physical fitness, this study recommends continuing to monitor screen time duration and increasing physical activity levels to mitigate potential risks associated with excessive screen use.
The role of parenting styles in increasing the achievement of Shorinji Kempo athletes: a literature review
Authors: Wali Carles Nyoman , Yuniana Rina , Nugroho Sigit , Pranata Doni , Talib Kamal Bin 
Published: October 2024

Achievement is one of the universal aspiration among athletes in the world of sports. The aim of this research is to determine the role of parenting styles in enhancing the performance of Shorinji Kempo athletes. The study employs a literature review method with a qualitative approach, using data collection techniques that include editing, organizing, and synthesizing information. The data analysis conducted through content analysis, utilizing internet applications such as Scopus, Sinta, and Google Scholar. The results of this study show parental involvement plays a crucial role in boosting the performance of Shorinji Kempo athletes, particularly during adolescence. Parents are the jewel and main educators for an athlete at home and in the social environment, even though they train with a coach and then study at school. While coaches and teachers contribute to an athlete's development, they act as extensions of parental guidance, providing education and support that may not be available at home. Facilities that cannot be obtained at home but are obtained at school can be complement for children in their development process, while coaches are developers of children's talents and interests that are previously identified by parents. The study concludes that the achievements of young athletes are significantly influenced by the parenting styles they experience. The role of parents in this case is to provide warm, caring, and affectionate family care that has maximum positive impact. As a result, athletes are more likely to grow into well-rounded adults with strong personal qualities, capable of fully realizing their talents and achieving excellence in sports performance.
Application of Information Link Control in Surgical Specimen Near-Miss Events in a South China Hospital: Nonrandomized Controlled Study
Authors: Chen Tingting , Tang Xiaofen , Xu Min , Jiang Yue , Zheng Fengyan 
Published: October 2024

Abstract

Background
Information control is a promising approach for managing surgical specimens. However, there is limited research evidence on surgical near misses. This is particularly true in the closed loop of information control for each link.

Objective
A new model of surgical specimen process management is further constructed, and a safe operating room nursing practice environment is created by intercepting specimen near-miss events through information safety barriers.

Methods
In a large hospital in China, 84,289 surgical specimens collected in the conventional information specimen management mode from January to December 2021 were selected as the control group, and 99,998 surgical specimens collected in the information safety barrier control surgical specimen management mode from January to December 2022 were selected as the improvement group. The incidence of near misses, the qualified rate of pathological specimen fixation, and the average time required for specimen fixation were compared under the 2 management modes. The causes of 2 groups of near misses were analyzed and the near misses of information safety barrier control surgical specimens were studied.

Results
Under the information-based safety barrier control surgical specimen management model, the incidence of adverse events in surgical specimens was reduced, the reporting of near-miss events in surgical specimens was improved by 100%, the quality control quality management of surgical specimens was effectively improved, the pass rate of surgical pathology specimen fixation was improved, and the meantime for surgical specimen fixation was shortened, with differences considered statistically significant at P<.05.

Conclusions
Our research has developed a new mode of managing the surgical specimen process. This mode can prevent errors in approaching specimens by implementing information security barriers, thereby enhancing the quality of specimen management, ensuring the safety of medical procedures, and improving the quality of hospital services.
Predicting Early Dropout in a Digital Tobacco Cessation Intervention: Replication and Extension Study
Authors: Yu Linda Q , Amato Michael S , Papandonatos George D , Cha Sarah , Graham Amanda L 
Published: October 2024

Background
Detecting early dropout from digital interventions is crucial for developing strategies to enhance user retention and improve health-related behavioral outcomes. Bricker and colleagues proposed a single metric that accurately predicted early dropout from 4 digital tobacco cessation interventions based on log-in data in the initial week after registration. Generalization of this method to additional interventions and modalities would strengthen confidence in the approach and facilitate additional research drawing on it to increase user retention.

Objective
This study had two research questions (RQ): RQ1—can the study by Bricker and colleagues be replicated using data from a large-scale observational, multimodal intervention to predict early dropout? and RQ2—can first-week engagement patterns identify users at the greatest risk for early dropout, to inform development of potential “rescue” interventions?

Methods
Data from web users were drawn from EX, a freely available, multimodal digital intervention for tobacco cessation (N=70,265). First-week engagement was operationalized as any website page views or SMS text message responses within 1 week after registration. Early dropout was defined as having no subsequent engagement after that initial week through 1 year. First, a multivariate regression model was used to predict early dropout. Model predictors were dichotomous measures of engagement in each of the initial 6 days (days 2-7) following registration (day 1). Next, 6 univariate regression models were compared in terms of their discrimination ability to predict early dropout. The sole predictor of each model was a dichotomous measure of whether users had reengaged with the intervention by a particular day of the first week (calculated separately for each of 2-7 days).

Results
For RQ1, the area under the receiver operating characteristic curve (AUC) of the multivariate model in predicting dropout after 1 week was 0.72 (95% CI 0.71-0.73), which was within the range of AUC metrics found in the study by Bricker and colleagues. For RQ2, the AUCs of the univariate models increased with each successive day until day 4 (0.66, 95% CI 0.65-0.67). The sensitivity of the models decreased (range 0.79-0.59) and the specificity increased (range 0.48-0.73) with each successive day.

Conclusions
This study provides independent validation of the use of first-week engagement to predict early dropout, demonstrating that the method generalizes across intervention modalities and engagement metrics. As digital intervention researchers continue to address the challenges of low engagement and early dropout, these results suggest that first-week engagement is a useful construct with predictive validity that is robust across interventions and definitions. Future research should explore the applicability and efficiency of this model to develop interventions to increase retention and improve health behavioral outcomes.
Implementation of the Observational Medical Outcomes Partnership Model in Electronic Medical Record Systems: Evaluation Study Using Factor Analysis and Decision-Making Trial and Evaluation Laboratory-Best-Worst Methods
Authors: Luo Ming , Gu Yu , Zhou Feilong , Chen Shaohong 
Published: October 2024

Background
Electronic medical record (EMR) systems are essential in health care for collecting and storing patient medical data. They provide critical information to doctors and caregivers, facilitating improved decision-making and patient care. Despite their significance, optimizing EMR systems is crucial for enhancing health care quality. Implementing the Observational Medical Outcomes Partnership (OMOP) shared data model represents a promising approach to improve EMR performance and overall health care outcomes.

Objective
This study aims to evaluate the effects of implementing the OMOP shared data model in EMR systems and to assess its impact on enhancing health care quality.

Methods
In this study, 3 distinct methodologies are used to explore various aspects of health care information systems. First, factor analysis is utilized to investigate the correlations between EMR systems and attitudes toward OMOP. Second, the best-worst method (BWM) is applied to determine the weights of criteria and subcriteria. Lastly, the decision-making trial and evaluation laboratory technique is used to illustrate the interactions and interdependencies among the identified criteria.

Results
In this research, we evaluated the AliHealth EMR system by surveying 98 users and practitioners to assess its effectiveness and user satisfaction. The study reveals that among all components, “EMR resolution” holds the highest importance with a weight of 0.31007783, highlighting its significant role in the evaluation. Conversely, “EMR ease of use” has the lowest weight of 0.1860467, indicating that stakeholders prioritize the resolution aspect over ease of use in their assessment of EMR systems.

Conclusions
The findings highlight that stakeholders prioritize certain aspects of EMR systems, with “EMR resolution” being the most valued component.
Impairment of Cardiovascular Functional Capacity in Mild-to-Moderate Kidney Dysfunction
Authors: Lim Kenneth , Nayor Matthew , Arroyo Eliott , Burney Heather N. , Li Xiaochun , Li Yang , Shah Ravi , Campain Joseph , Wan Douglas , Ting Stephen , Hiemstra Thomas F. , Thadhani Ravi , Moe Sharon , Zehnder Daniel , Larson Martin G. , Vasan Ramachandran S. , Lewis Gregory D. 
Published: October 2024

Key Points

Mild-to-moderate CKD is associated with impairment in cardiovascular functional capacity as assessed by oxygen uptake at peak exercise (VO2Peak).Cardiac output is significantly reduced in patients with mild-to-moderate CKD and is associated with impaired VO2Peak.Assessment of VO2Peak by cardiopulmonary exercise testing can detect decrements in cardiovascular function during early stages of kidney function decline that may not be captured using resting left ventricular geometric indices alone.

Background
Traditional diagnostic tools that assess resting cardiac function and structure fail to accurately reflect cardiovascular alterations in patients with CKD. This study sought to determine whether multidimensional exercise response patterns related to cardiovascular functional capacity can detect abnormalities in mild-to-moderate CKD.

Methods
In a cross-sectional study, we examined 3075 participants from the Framingham Heart Study (FHS) and 451 participants from the Massachusetts General Hospital Exercise Study (MGH-ExS) who underwent cardiopulmonary exercise testing. Participants were stratified by eGFR: eGFR ≥90, eGFR 60–89, and eGFR 30–59. Our primary outcomes of interest were peak oxygen uptake (VO2Peak), VO2 at anaerobic threshold (VO2AT), and ratio of minute ventilation to carbon dioxide production (VE/VCO2). Multiple linear regression models were fitted to evaluate the associations between eGFR group and each outcome variable adjusted for covariates.

Results
In the FHS cohort, 1712 participants (56%) had an eGFR ≥90 ml/min per 1.73 m2, 1271 (41%) had an eGFR of 60–89 ml/min per 1.73 m2, and 92 (3%) had an eGFR of 30–59 ml/min per 1.73 m2. In the MGH-ExS cohort, 247 participants (55%) had an eGFR ≥90 ml/min per 1.73 m2, 154 (34%) had an eGFR of 60–89 ml/min per 1.73 m2, and 50 (11%) had an eGFR of 30–59 ml/min per 1.73 m2. In FHS, VO2Peak and VO2AT were incrementally impaired with declining kidney function (P < 0.001); however, this pattern was attenuated after adjustment for age. Percent-predicted VO2Peak at AT was higher in the lower eGFR groups (P < 0.001). In MGH-ExS, VO2Peak and VO2AT were incrementally impaired with declining kidney function in unadjusted and adjusted models (P < 0.05). VO2Peak was associated with eGFR (P < 0.05) in all models even after adjusting for age. On further mechanistic analysis, we directly measured cardiac output (CO) at peak exercise by right heart catheterization and found impaired CO in the lower eGFR groups (P ≤ 0.007).

Conclusions
Cardiopulmonary exercise testing–derived indices may detect impairment in cardiovascular functional capacity and track CO declines in mild-to-moderate CKD.
Cholestasis in Chronic Liver Disease and the Role of Ademetionine in its Treatment (Literature Review and Expert Panel Resolution)
Authors: Raikhelson K. L. , Bueverov A. O. , Kondrashina E. A. , Maevskaya M. V. , Khlynov I. B. , Shirokova E. N. , Ivashkin V. T. 
Published: October 2024

Aim: to analyse the principles of diagnosis and treatment of intrahepatic cholestasis in chronic liver diseases, to present data on the effectiveness of ademetionine in the treatment of chronic liver diseases with intrahepatic cholestasis and the materials of the Expert Meeting held in 2023. Key points. During the Expert Meeting, the problems of diagnostics and treatment of intrahepatic cholestasis in various chronic liver diseases were discussed, the effectiveness of ademetionine was clarified, and optimal regimens for its administration were determined. The relevance of the existing algorithm for diagnosing cholestasis in real clinical practice was assessed. The effectiveness of ademetionine in the treatment of various liver diseases occurring with intrahepatic cholestasis (cholestatic forms of drug-induced liver damage, alcoholic liver disease, non-alcoholic liver disease, primary biliary cholangitis) was demonstrated, manifested by a decrease in clinical and laboratory signs of cholestasis. The anticholestatic mechanisms of ademetionine action were clarified, which consist in normalizing the fluidity of hepatocyte membranes, regulating the activity of Nrf2, a key transcription factor, suppressing lipid peroxidation and the resulting damage to hepatocytes and cholangiocytes. Optimal regimens for prescribing ademetionine for various clinical situations were considered. Conclusions. Ademetionine is an effective drug that, due to its pleiotropic action and favourable safety profile, can be used in various chronic liver diseases accompanied by cholestasis, including as a part of the complex therapy.
Methodological Guidelines of the Scientific Community for Human Microbiome Research (CHMR) and the Russian Gastroenterology Association (RGA) on the Use of Probiotics, Prebiotics, Synbiotics, Metabiotics and Functional Foods Enriched with Them for the Treatment and Prevention of Gastrointestinal Diseases in Adults and Children
Authors: Ivashkin V. T. , Gorelov A. V. , Abdulganieva D. I. , Alekseeva O. P. , Alekseenko S. A. , Baranovsky A. Yu. , Zakharova I. N. , Zolnikova O. Yu. , Ivashkin K. V. , Ivashkina N. Yu. , Korochanskaya N. V. , Mammaev S. N. , Nikolaeva S. V. , Poluektova E. A. , Trukhmanov A. S. , Usenko D. V. , Khlynov I. B. , Tsukanov V. V. , Shifrin O. S. , Berezhnaya I. V. , Lapina T. L. , Maslennikov R. V. , Sugian N. G. , Ulyanin A. I. 
Published: October 2024

Aim: to optimize outcomes of the treatment and prevention of gastrointestinal diseases in adults and children. Key points. The Methodological Guidelines contain sections on the terminology, classification, mechanisms of action, requirements for sale in the Russian Federation, requirements for proving the efficacy and safety of probiotics, prebiotics, synbiotics and metabiotics, as well as functional foods enriched with them. An overview of relevant data allowing to include these drugs and products in the treatment an d prevention of gastrointestinal diseases in adults and children is presented. Conclusion. The clinical efficacy of probiotics, prebiotics, synbiotics and metabiotics depends on the specificity and quantity of their components, the dosage form, the regimen and duration of treatment. Products and functional foods with proven efficacy and safety are recommended for the treatment and prevention of gastrointestinal diseases in adults and children.
Bado type III Monteggia fractures have a high injury- and treatment-related complication rate: a single center study of 73 fractures
Authors: Zilliacus Kaj , Nietosvaara Yrjänä , Helenius Ilkka , Kämppä Niko , Vuorimies Ilkka , Grahn Petra 
Published: October 2024

Background and purpose: Monteggia fractures can be problematic injuries. The aim of this population-based study is to evaluate the risk of complications according to the Bado types, clinical outcome, and incidence.Methods: 72 children (median age 6, range 2–11 years) with 73 Monteggia fractures treated during 2014–2022 were identified from the institutional fracture register. Timing of diagnosis, complications, and method of treatment were registered. Outcomes were assessed at mean 4 years (1–9) follow-up in 68 (94%) children. The census population (< 16 years old) in Helsinki metropolitan area during the study period was assessed.Results: Bado types I (n = 43) and III (n = 27) comprised all but 3 of the fractures. Diagnosis was made on admission in 57, and with a 1–8-day delay in 16 children. 8 children had sustained an associated nerve injury. 35 children were treated operatively, 7 after failed closed treatment. 4 reoperations were performed, including 3 ulnar osteotomies. The risk of complications (odds ratio [OR] 4.9, 95% confidence interval [CI] 1.7–14) and closed treatment failures (OR 12.3, CI 1.3–118) was higher in Bado type III than in type I injuries. 60 children attended for clinical follow-up, all had congruent radio-humeral joints and full range of elbow and forearm motion. Mean PedsQL was 94 (72–100) and QuickDash 3 (0–13). 8 additional children reported normal elbow functions by phone. The calculated mean annual incidence of Monteggia injuries was 2.9/100,000 children.Conclusion: Monteggia fractures are rare (2.9/100,000 yearly). Bado type III injuries are associated with a high risk of complications.
Made of flint, bone and boar’s tusks – burial goods from male grave No. 2 in Świerszczów (Kolonia) 28, Hrubieszów District – attributed to the Malice culture – in the light of traceological analysis
Authors: Zakościelna Anna , Osipowicz Grzegorz 
Published: October 2024

The article presents the results of a traceological analysis conducted on artefacts made of bone, boar’s tusks and flint – the only funerary goods discovered in Grave No. 2 at Świerszczów (Kolonia) Site 28, in which an adult male was buried. Despite the lack of pottery vessels that could indicate cultural affiliation, the grave is attributed to the Rzeszów phase of the Malice culture, i.e., the final, Eneolithic, stage of that culture. This attribution is based on 14C dating and on the presence in the grave of artefacts made of boar’s tusks and flint burins. Microscopic analysis conducted on the discovered artefacts revealed traces related to their production, use and repair on their surfaces. Most items bear traces indicating their usage in processing soft materials, like siliceous (wild and domesticated) plants and hide. Interestingly, the artefacts with holes for hanging – traditionally regarded as adornments in archaeological literature – were also employed in different activities.