bluuebunny/crossref_metadata_2025_split huggingface dataset:
The urgent need for a harmonized severity scoring system for acute allergic reactions
Authors: Muraro A. , Fernandez‐Rivas M. , Beyer K. , Cardona V. , Clark A. , Eller E. , Hourihane J. O'B. , Jutel M. , Sheikh A. , Agache I. , Allen K. J. , Angier E. , Ballmer‐Weber B. , Bilò M. B. , Bindslev‐Jensen C. , Camargo C. A. , Cianferoni A. , DunnGalvin A. , Eigenmann P. A. , Halken S. , Hoffmann‐Sommergruber K. , Lau S. , Nilsson C. , Poulsen L. K. , Rueff F. , Spergel J. , Sturm G. , Timmermans F. , Torres M. J. , Turner P. , van Ree R. , Wickman M. , Worm M. , Mills E. N. C. , Roberts G. 
Published: January 2018

AbstractThe accurate assessment and communication of the severity of acute allergic reactions are important to patients, clinicians, researchers, the food industry, and public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach, and none has been validated. Their wide range of outcome formats has led to difficulties with interpretation and application. Therefore, there is a persisting need for an appropriately developed and validated severity scoring system for allergic reactions that work across the range of allergenic triggers and address the needs of different stakeholder groups. We propose a novel approach to develop and then validate a harmonized scoring system for acute allergic reactions, based on a data‐driven method that is informed by clinical and patient experience and other stakeholders’ perspectives. We envisage two formats: (i) a numerical score giving a continuum from mild to severe reactions that are clinically meaningful and are useful for allergy healthcare professionals and researchers, and (ii) a three‐grade‐based ordinal format that is simple enough to be used and understood by other professionals and patients. Testing of reliability and validity of the new approach in a range of settings and populations will allow eventual implementation of a standardized scoring system in clinical studies and routine practice.
The asthma‐rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults
Authors: Siroux V. , Ballardini N. , Soler M. , Lupinek C. , Boudier A. , Pin I. , Just J. , Nadif R. , Anto J. M. , Melen E. , Valenta R. , Wickman M. , Bousquet J. 
Published: January 2018

AbstractBackgroundChildren with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity.MethodsIgE reactivity to 64 micro‐arrayed aeroallergen molecules was determined with the MeDALL‐chip in samples from the French EGEA study (n = 840, age = 40.7 ± 17.1) and the Swedish population‐based birth cohort BAMSE (n = 786, age = 16 ± 0.26). The age‐ and sex‐adjusted associations between the number of IgE‐reactive allergen molecules (≥0.3 ISU) and the asthma‐rhinitis phenotypes were assessed using a negative binomial model.ResultsGroups representing 4 phenotypes were identified: no asthma‐no rhinitis (A−R−; 30% in EGEA and 54% in BAMSE), asthma alone (A+R−; 11% and 8%), rhinitis alone (A−R+; 15% and 24%) and asthma‐rhinitis (A+R+; 44% and 14%). The numbers of IgE‐reactive aeroallergen molecules significantly differed between phenotypes (median in A−R−, A+R−, A−R+ and A+R+: 0, 1, 2 and 7 in EGEA and 0, 0, 3 and 5 in BAMSE). As compared to A−R− subjects, the adjusted ratio of the mean number of IgE‐reactive molecules was higher in A+R+ than in A+R− or A−R+ (10.0, 5.4 and 5.0 in EGEA and 7.2, 0.7 and 4.8 in BAMSE).ConclusionThe A+R+ phenotype combined the sensitization pattern of both the A−R+ and A+R− phenotypes. This multimorbid polysensitized phenotype seems to be generalizable to various ages and allergenic environments and may be associated with specific mechanisms.
Characterization of CD34+ hematopoietic cells in systemic mastocytosis: Potential role in disease dissemination
Authors: Mayado A. , Teodosio C. , Dasilva‐Freire N. , Jara‐Acevedo M. , Garcia‐Montero A. C. , Álvarez‐Twose I. , Sánchez‐Muñoz L. , Matito A. , Caldas C. , Muñoz‐González J. I. , Henriques A. , Sánchez‐Gallego J. I. , Escribano L. , Orfao A. 
Published: January 2018

AbstractBackgroundRecent studies show that most systemic mastocytosis (SM) patients, including indolent SM (ISM) with (ISMs+) and without skin lesions (ISMs−), carry the KIT D816V mutation in PB leukocytes. We investigated the potential association between the degree of involvement of BM hematopoiesis by the KIT D816V mutation and the distribution of different maturation‐associated compartments of bone marrow (BM) and peripheral blood (PB) CD34+ hematopoietic precursors (HPC) in ISM and identified the specific PB cell compartments that carry this mutation.MethodsThe distribution of different maturation‐associated subsets of BM and PB CD34+ HPC from 64 newly diagnosed (KIT‐mutated) ISM patients and 14 healthy controls was analyzed by flow cytometry. In 18 patients, distinct FACS‐purified PB cell compartments were also investigated for the KIT mutation.ResultsISM patients showed higher percentages of both BM and PB MC‐committed CD34+ HPC vs controls, particularly among ISM cases with MC‐restricted KIT mutation (ISMMC); this was associated with progressive blockade of maturation of CD34+ HPC to the neutrophil lineage from ISMMC to multilineage KIT‐mutated cases (ISMML). Regarding the frequency of KIT‐mutated cases and cell populations in PB, variable patterns were observed, the percentage of KIT‐mutated PB CD34+ HPC, eosinophils, neutrophils, monocytes and T cells increasing from ISMs−MC and ISMs+MC to ISMML patients.ConclusionThe presence of the KIT D816V mutation in PB of ISM patients is associated with (early) involvement of circulating CD34+ HPC and multiple myeloid cell subpopulations, KIT‐mutated PB CD34+ HPC potentially contributing to early dissemination of the disease.
Letter: the safety of herpes zoster vaccination for patients with inflammatory bowel disease being treated with anti‐TNF medications
Authors: Côté‐Daigneault J. , Luong M.L. , Colombel J.‐F. , Peerani F. 
Published: January 2018

Linked ContentThis article is linked to Khan et al and Khan and Lewis papers. To view these articles visit https://doi.org/10.1111/apt.14257 and https://doi.org/10.1111/apt.14460.
Letter: therapeutic drug monitoring and inflammatory bowel disease—a call for an urgent standardization of the results
Authors: Ribaldone D. G. , Saracco G. M. , Astegiano M. , Pellicano R. 
Published: January 2018

Linked ContentThis article is linked to Bar‐Yoseph et al paper. To view this article visit https://doi.org/10.1111/apt.14410.
Letter: the safety of herpes zoster vaccination for patients with inflammatory bowel disease being treated with anti‐TNF medications—authors’ reply
Authors: Khan N. , Lewis J. D. 
Published: January 2018

Linked ContentThis article is linked to Khan et al and Côté‐Daigneault et al papers. To view these articles visit https://doi.org/10.1111/apt.14257 and https://doi.org/10.1111/apt.14435.
Editorial: the role of colonic inflammation in the progression of liver disease in primary sclerosing cholangitis—Authors’ reply and Letter: the effects of colectomy prior to the diagnosis of primary sclerosing cholangitis on prognosis may have been overestimated
Authors: Nordenvall C. , Bergquist A. 
Published: January 2018

Linked ContentThis article is linked to Nordenvall et al, Sabino and Torres, and Tao and Wang papers. To view these articles visit https://doi.org/10.1111/apt.14393, https://doi.org/10.1111/apt.14418 and https://doi.org/10.1111/apt.14439.
Empirical evaluation of different classroom spaces on students' perceptions of the use and effectiveness of 1‐to‐1 technology
Authors: Byers Terry , Hartnell‐Young Elizabeth , Imms Wesley 
Published: January 2018

AbstractThis study explored the effect of different classroom spatial layouts on student perceptions of digital technology in a secondary schooling environment. A quasi‐experimental approach facilitated by a Single Subject research design (SSRD) isolated the impact of two learning spaces—traditional' classrooms, and ‘new generation learning spaces’ (NGLS), on students' perceived effectiveness, use and value of one‐to‐one technology as a learning tool. Results from quantitative analyses over the period of a school year indicated that different spatial configurations had a measurable effect on how students' perceived the effectiveness of the affordances of digital technology, with improvements often linked to NGLS. However, the evidence suggests that a change in learning space alone will not increase learning. A change in space supports those teachers who are able and willing to integrate the affordances of technology into their practice. Building on the collective methodologies of earlier work this analysis has reinforced the credibility of this unique methodological approach, arguing this evaluative strategy offers the capacity to generate much needed robust empirical data on evaluation of learning environments in a secondary school setting.
Synapsin III is a key component of α‐synuclein fibrils in Lewy bodies of PD brains
Authors: Longhena Francesca , Faustini Gaia , Varanita Tatiana , Zaltieri Michela , Porrini Vanessa , Tessari Isabella , Poliani Pietro Luigi , Missale Cristina , Borroni Barbara , Padovani Alessandro , Bubacco Luigi , Pizzi Marina , Spano PierFranco , Bellucci Arianna 
Published: January 2018

AbstractLewy bodies (LB) and Lewy neurites (LN), which are primarily composed of α‐synuclein (α‐syn), are neuropathological hallmarks of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We recently found that the neuronal phosphoprotein synapsin III (syn III) controls dopamine release via cooperation with α‐syn and modulates α‐syn aggregation. Here, we observed that LB and LN, in the substantia nigra of PD patients and hippocampus of one subject with DLB, displayed a marked immunopositivity for syn III. The in situ proximity ligation assay revealed the accumulation of numerous proteinase K‐resistant neuropathological inclusions that contained both α‐syn and syn III in tight association in the brain of affected subjects. Most strikingly, syn III was identified as a component of α‐syn‐positive fibrils in LB‐enriched protein extracts from PD brains. Finally, a positive correlation between syn III and α‐syn levels was detected in the caudate putamen of PD subjects. Collectively, these findings indicate that syn III is a crucial α‐syn interactant and a key component of LB fibrils in the brain of patients affected by PD.
Sociocultural Influences on the Sociopolitical Development of African American Youth
Authors: Anyiwo Nkemka , Bañales Josefina , Rowley Stephanie J. , Watkins Daphne C. , Richards‐Schuster Katie 
Published: January 2018

AbstractSociopolitical development (SPD) is the process by which individuals become aware of social inequality, recognize the status of their social identities, and engage in activism. For racially marginalized youth, race is an important aspect of their SPD. Yet few studies have considered the connections between racial factors and youth's SPD. In this article, we introduce an integrative model situating racial sociocultural processes (i.e., racial identity, racial socialization, and experiences of racial discrimination) within current SPD theory. In particular, we look at African American youth as a case study to discuss how sociocultural factors can contribute to youth's awareness of structures of social inequality (i.e., critical social analysis) and engagement in action against social inequality (i.e., sociopolitical action). We conclude with suggestions for research.
Static hyperinflation is associated with ventilatory limitation and exercise tolerance in adult cystic fibrosis
Authors: Stevens Daniel 
Published: January 2018

AbstractIntroductionLung hyperinflation is a potential mechanism limiting exercise tolerance. However, available data on the impact of static hyperinflation on exercise performance in adult cystic fibrosis are lacking. Furthermore, the relative contribution of both static and dynamic hyperinflation to exercise performance is unknown.ObjectivesThe aim of this study was to determine the impact of static hyperinflation on exercise tolerance and lung dynamics in adult cystic fibrosis.MethodsClinical data of 107 adult patients with cystic fibrosis, including pulmonary function, lung volumes and cardiopulmonary exercise from the Toronto Cystic Fibrosis database, were collected and analyzed. Patients were classified as having static hyperinflation with a residual volume to total lung capacity (RV/TLC) ratio of 30% or greater.ResultsPatients with static hyperinflation demonstrated a significant reduction in exercise performance [peak oxygen uptake (% predicted) 70 ± 17 vs 80 ± 17; P = .006] and were more likely to experience ventilatory limitation when exercising (Fisher's exact test P < .001). Correlation analysis showed significant relationships between measures of static hyperinflation [RV/TLC ratio (%)] and exercise performance [peak oxygen uptake (% predicted); r = −.38, P < .001] and dynamic hyperinflation (r = −.35, P < .001). Multiple linear regression showed that the contribution of static hyperinflation to exercise performance [peak oxygen uptake (% predicted)] was greater than that of airway obstruction (forced expiratory volume in 1 second).ConclusionClinicians working with this patient group in a pulmonary rehabilitation or health care setting may wish to consider using measures of static hyperinflation as end points to determine program or treatment efficacy.
Defining expanded areas in EBUS sampling: EBUS guided trans‐ and intra‐pulmonary artery needle aspiration, with review of transvascular EBUS
Authors: Mehta Ravindra M. , Biraris Pavankumar R. , Pattabhiraman Vallandramam , Srinivasan Arjun , Singla Abhinav , Kumar Sunil , Cutaia Michael 
Published: January 2018

AbstractBackgroundEndobronchial Ultrasound‐guided Transbronchial Needle Aspiration (EBUS‐TBNA) has revolutionized the diagnostic approach to mediastinal diseases. Lesions located lateral to the pulmonary artery (trans‐PA, Station 5), or in the lumen of the PA (intra‐PA) are in the ‘blind‐spot’ of EBUS.ObjectivesWe describe a case series where EBUS guided trans‐pulmonary or intra‐pulmonary aspiration (EBUS‐TIPNA) was used for diagnosis.MethodsRetrospective analysis of 10 patients who had EBUS‐TIPNA over 3 years in 2 centres. The inclusion criteria included patients with station 5 lesions, or intrapulmonary artery lesions, where no other option was possible.ResultsThe study included 4 males and 6 females, mean age 52 years, with 7 trans‐PA and 3 intra‐PA lesions. Adequacy was seen in 10/10, and a definitive diagnosis was made in 9/10 patients. There were no procedure‐related complications.ConclusionEBUS‐TIPNA can be done as a safe and successful procedure and adds to the armamentarium of Convex Probe‐EBUS (CP‐EBUS), in carefully selected patients.
Erosive pustulöse Dermatose der Kopfhaut: Neubewertung einer zu wenig beachteten Entität
Authors: Wilk Michael , Zelger Bettina G. , Hauser Undine , Höpfl Reinhard , Zelger Bernhard 
Published: January 2018

ZusammenfassungDie erosive pustulöse Dermatose der Kopfhaut (EPDK) ist eine entzündliche Erkrankung unbekannter Ätiologie. Wir besprechen die EPDK und präsentieren unsere eigene klinische und histopathologische Erfahrung von elf Patienten. Die EPDK neigt dazu, spontan die kahle Kopfhaut älterer Patienten zu befallen. Anamnestisch wird häufig – so auch bei vier unserer Patienten – eine vorausgegangene Operation an selbiger Stelle angegeben. Koronare Herzerkrankung, cerebraler Insult, arterieller Hypertonus, Diabetes mellitus und ernste Krebserkrankungen wurden ebenfalls häufig als Komorbidität diagnostiziert. Die meisten Patienten zeigen trotz antiinflammatorischer Lokaltherapie einen schwankenden klinischen Verlauf, bei einigen heilt die Läsion unter Narbenbildung ab. Histopathologisch findet sich eine Kruste oder Erosion mit Granulationsgewebe‐ähnlichen Veränderungen im Korium mit späterer Entstehung einer Narbe. Neben einer lokalen und aktinischen Schädigung könnten eine eingeschränkte Immunität und Mikrozirkulation prädisponierende Faktoren der Erkrankung sein. Analog zum Pyoderma gangraenosum muss die EPDK bei nichtheilenden Wunden älterer Patienten bedacht werden, nachdem die Differenzialdiagnosen, die diese Erkrankung simulieren, ausgeschlossen wurden. Da vorausgegangene oder benachbarte Basalzell‐ und insbesondere Plattenepithelkarzinome häufig sind und infiltrative Varianten jenseits des klinisch sichtbaren Krankheitsprozesses vorkommen, kann im Zweifelsfall eine sogenannte histologische Kartierung der umgebenden Haut ratsam sein.
Not Sustainable: India's Trade and Current Account Deficits
Authors: Nabar‐Bhaduri Suranjana 
Published: January 2018

ABSTRACTIndia's trade balance and current account have shown persistent deficits for a major part of its post‐independence period. Since the mid‐2000s, trade deficits have increased perilously, with a sharp rise in both oil and non‐oil imports. India has relied on services exports, remittances and capital inflows to offset trade deficits and sustain the current account deficit. This article examines the sustainability of relying on capital inflows, remittances and services exports to sustain these persistent trade and current account deficits. It argues that all three sources entail elements of fragility. The recent global economic slowdown, economic recessions in the United States and Europe, slow economic recovery, low growth forecasts and possibility of a secular slowdown in the United States and Europe raise questions about whether services exports and remittances can continue to generate sufficient earnings to offset trade deficits. Relying on capital inflows also carries risks of financial fragility, with short‐term capital inflows and external commercial borrowings becoming more prominent in the Indian economy.
Exploiting the “Win But Does Not Cover” Phenomenon in College Basketball
Authors: Berkowitz Jason P. , Depken II Craig A. , Gandar John M. 
Published: January 2018

AbstractWolfers (2006) was the first to document that heavy favorites in college basketball win but fail to cover the pre‐game point spread at a statistically higher rate than expected. We generate a hedged strategy to exploit the “win but does not cover” phenomenon using two wagers: a bet on the underdog sides line and a bet on the favorite money line. While one bet is guaranteed to win regardless of the outcome, both bets win if the favorite wins but does not cover. We show that the minimum‐variance portfolio best exploits this anomaly, yielding an average return of 0.34% per game and a positive return in five of the seven seasons of college basketball analyzed.
Relative Liquidity, Fund Flows and Short‐Term Demand: Evidence from Exchange‐Traded Funds
Authors: Broman Markus S. , Shum Pauline 
Published: January 2018

AbstractWe show that highly liquid Exchange‐Traded Funds (ETFs), especially those that are more liquid than their underlying basket of securities (i.e., positive relative liquidity), are particularly attractive to investors. Using three definitions of liquidity, we find that relative liquidity predicts net fund flows, as well as inflows and outflows positively and significantly. We further document a liquidity clientele among institutional investors: (i) relative liquidity is significantly more important for short‐ than for long‐term investors; and (ii) relative liquidity is inversely related to investors’ average holding duration in the ETFs. These two findings provide evidence that relative liquidity encourages short‐term demand.
Strong evidence for changing fish reproductive phenology under climate warming on the Tibetan Plateau
Authors: Tao Juan , He Dekui , Kennard Mark J. , Ding Chengzhi , Bunn Stuart E. , Liu Chunlong , Jia Yintao , Che Rongxiao , Chen Yifeng 
Published: January 2018

AbstractPhenological responses to climate change have been widely observed and have profound and lasting effects on ecosystems and biodiversity. However, compared to terrestrial ecosystems, the long‐term effects of climate change on species’ phenology are poorly understood in aquatic ecosystems. Understanding the long‐term changes in fish reproductive phenology is essential for predicting population dynamics and for informing management strategies, but is currently hampered by the requirement for intensive field observations and larval identification. In this study, a very low‐frequency sampling of juveniles and adults combined with otolith measurements (long axis length of the first annulus; LAFA) of an endemic Tibetan Plateau fish (Gymnocypris selincuoensis) was used to examine changes in reproductive phenology associated with climate changes from the 1970s to 2000s. Assigning individual fish to their appropriate calendar year class was assisted by dendrochronological methods (crossdating). The results demonstrated that LAFA was significantly and positively associated with temperature and growing season length. To separate the effects of temperature and the growing season length on LAFA growth, measurements of larval otoliths from different sites were conducted and revealed that daily increment additions were the main contributor (46.3%), while temperature contributed less (12.0%). Using constructed water‐air temperature relationships and historical air temperature records, we found that the reproductive phenology of G. selincuoensis was strongly advanced in the spring during the 1970s and 1990s, while the increased growing season length in the 2000s was mainly due to a delayed onset of winter. The reproductive phenology of G. selincuoensis advanced 2.9 days per decade on average from the 1970s to 2000s, and may have effects on recruitment success and population dynamics of this species and other biota in the ecosystem via the food web. The methods used in this study are applicable for studying reproductive phenological changes across a wide range of species and ecosystems.