bluuebunny/crossref_metadata_2025_split huggingface dataset:
HSV-1 Infection AltersMAPTSplicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease
Authors: Ijezie Emmanuel C , Miller Michael J , Hardy Celine , Jarvis Ava R. , Czajka Timothy F , D’Brant Lianna , Rugenstein Natasha , Waickman Adam , Murphy Eain , Butler David C 
Published: October 2024

ABSTRACTINTRODUCTIONHerpes simplex virus 1 (HSV-1) infection alters critical markers of Alzheimer’s Disease (AD) in neurons. One key marker of AD is the hyperphosphorylation of Tau, accompanied by altered levels of Tau isoforms. However, an imbalance in these Tau splice variants, specifically resulting from altered 3R to 4RMAPTsplicing of exon 10, has yet to be directly associated with HSV-1 infectionMETHODSTo this end, we infected 2D and 3D human neural models with HSV-1 and monitoredMAPTsplicing and Tau phosphorylation. Further, we transduced SH-SY5Y-neurons with HSV-1 ICP27 which alters RNA splicing to analyze if ICP27 alone is sufficient to induce alteredMAPTexon 10 splicing.RESULTSWe show that HSV-1 infection induces altered splicing ofMAPTexon 10, increasing 4R-Tau protein levels, Tau hyperphosphorylation, and Tau oligomerization.DISCUSSIONOur experiments reveal a novel link between HSV-1 infection and the development of cytopathic phenotypes linked with AD progression.HIGHLIGHTSHSV-1 infection in forebrain organoids reduces the neurite length of MAP2-positive neurons.HSV-1 infection increases Tau hyperphosphorylation in both two-month-old and four-month-old forebrain organoids.HSV-1 infection increases Exon 10 containing (4R)MAPTmRNA and 4R-Tau protein expression in both forebrain organoids and human SH-SY5Y-neurons.HSV-1 ICP27 is both necessary and sufficient to induce increased 4RMAPTmRNA and 4R-Tau protein expression in SH-SY5Y-neurons.HSV-1 infection increases Tau oligomerization in both forebrain organoids and SH-SY5Y-neurons.
An Update on Active and Passive Surveillance for African Swine Fever in the Dominican Republic
Authors: Schambow Rachel A. , Carrasquillo Nianet , Kreindel Silvia , Perez Andres M. 
Published: October 2024

AbstractAfrican Swine Fever (ASF) is a viral, hemorrhagic disease of swine that is reportable to the World Organisation for Animal Health. Since 2007, ASF has been expanding globally and caused severe disruption to the global swine industry. In 2021, ASF was detected in the Dominican Republic, prompting an emergency response from local and international officials. Nearly three years later, ASF is still present in the country despite control efforts. This study used data from January 2023-March 2024 from government-mandated sampling of commercial farms, a newly initiated active surveillance program of backyard farms, and passive reports to provide a comprehensive and descriptive assessment of ASF in the Dominican Republic. The attack rate for each region was calculated, and the reproductive ratio (R0) was estimated using the doubling time method. ASF continues to be distributed throughout the Dominican Republic with lower attack rates in central regions and R0nearing 1. These results suggest that ASF in the country is reaching a stable state that does not resemble an epidemic situation. This may suggest the need to change from an approach of emergency response to one of sustained and progressive control, ultimately for the long-term goal of ASF eradication in the Dominican Republic.
Transcriptomic bases of within- and trans-generational predator-induced plasticity in the freshwater snailPhysa acuta
Authors: Dejeux Léo , Saclier Nathanaëlle , Tariel-Adam Juliette , Hoareau Maxime , Lefébure Tristan , Konecny Lara , Plénet Sandrine , Luquet Emilien 
Published: October 2024

AbstractInducible defences in response to predation risk are a well-known example of adaptive phenotypic plasticity. While inducible defences have been mainly studied within a generation (within-generational plasticity), there is now clear evidence that the ancestral exposure to predation risk can influence the defences expressed by the offspring, even if they have not been exposed themselves (transgenerational plasticity). The molecular mechanisms allowing the transmission of environmental information across generations are still misunderstood. In this study, we combined measures of anti-predator responses (behavioural and morphological) with transcriptomic investigations across two generations in the freshwater snailPhysa acuta. We hypothesised that both within- and transgenerational plasticity would induce phenotypic changes associated with differential gene expression. Our results confirmed within- and transgenerational plasticity: F1 snails have responded to predator-cue exposure by increasing escape behaviour, reducing shell length, and developing thicker and slender shells and F2 from exposed parents have shown similar responses. Within- and transgenerational plasticity were accompanied by the differential expression of 78 genes (77 up- and 1 down-regulated) and 14 differentially expressed genes (13 up- and 1 down-regulated), respectively. Within- and transgenerational plasticity did not share common differentially expressed genes but some differentially expressed genes in F1 are also highly expressed in F2 and overall, the molecular functions were similar, involving metabolism and transcription regulation. The quantitatively low molecular response associated with transgenerational plasticity suggests that gene expression changes induced by parental exposure may have occurred early in development and have decreased at adult stage.
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A
Authors: Akaaboune Sarah Reem , Javed Aadil , Bui Sarah , Wierenga Alissa , Wang Yanzhuang 
Published: October 2024

ABSTRACTThe Golgi apparatus plays a crucial role in the delivery of lysosomal enzymes. Golgi Reassembly Stacking Proteins, GRASP55 and GRASP65, are vital for maintaining Golgi structure and function. GRASP55 depletion results in the missorting and secretion of the lysosomal enzyme Cathepsin D (Xianget al., 2013), though the mechanisms remain unclear. In this study, we conducted secretomic analyses of GRASP55 knockout (KO) cells and found a significant increase in lysosome-associated proteins in the extracellular medium. Using the lysosomal beta-hexosaminidase subunit alpha (HEXA) as a model, we found that GRASP55 depletion disrupted normal trafficking and processing of HEXA, resulting in increased secretion of the immature (pro-form) HEXA into the extracellular milieu, along with decreased levels of the mature form and enzymatic activity within the cell. GRASP55 depletion significantly reduced the complex formation between HEXA and mannose-6-phosphate (M6P) receptors (MPR), despite no overall change in MPR expression. And finally, we found there was a notable reduction in the expression of GNPTAB, leading to a reduction in M6P modification of HEXA, hindering its efficient targeting to lysosomes. These findings reveal the role of GRASP55 in regulating lysosomal enzyme dynamics, emphasizing its role in the sorting and trafficking of lysosomal proteins.
Study of net-baryon higher moments in PNJL model and their expectation for net-proton using the subensemble acceptance method for the search of QCD critical point
Authors: Sarkar A. , Deb P. , Mandal Bidhan , Varma R. 
Published: October 2024

The critical point is one of the most important aspects of the QCD phase diagram of strongly interacting matter. The nonmonotonic behavior of the higher-order moments of conserved quantities like net-baryon (ΔB), net-charge (ΔQ), and net-strangeness (ΔS) are believed to be the signatures of the QCD critical point as a function of energy. We study the effect of the QCD critical point on moments of net-baryon in the Polyakov loop enhanced Nambu-Jona-Lasinio (PNJL) model of QCD with six-quark and eight-quark interactions for finite and infinite volume systems. The study is performed at energies similar to Relativistic Heavy-Ion Collider beam energy scan. Experimentally measuring conserved quantities is difficult due to systematic limitations. Therefore, net-proton, net-pion, and net-kaon are measured as the proxy of ΔB, ΔQ, and ΔS. Recent studies in the subensemble acceptance method on the hadron resonance gas (HRG) model show the dependency of the measured higher-order moment on the experimental acceptance. We applied the subensemble acceptance method to analyze the behavior of κσ2 of net-baryon distribution within the subvolume system for various acceptance fractions. These results can be directly mapped to the subvolume (particle) percentage of the total volume (conserved quantities). Our findings are compared to the solenoidal tracker at RHIC (STAR) net-proton and proton data with different energies to investigate the presence of the critical point. Additionally, these results are also compared with the ultrarelativistic quantum molecular dynamics (UrQMD), HRG model, and available lattice data.

Published by the American Physical Society
2024
Fundamental tests of
P
and
CP
symmetries using octet baryons at the
J/ψ
threshold
Authors: Du Yong , He Xiao-Gang , Ma Jian-Ping , Du Xin-Yu 
Published: October 2024

We systematically investigate tests of the parity P and the combined parity and charge-conjugate CP symmetries from differential angular distributions of J/ψ decaying into the lowest-lying baryon pairs at BESIII and the next-generation super tau-charm facilities (STCFs). Large corrections from Z and W exchange induced parity-violating effects are found for J/ψ decays with large logarithms resummed up to O(αs). The parity-violating asymmetries on the production and the decay sides of J/ψ are both estimated to be of O(10−4), thus barely observable with the 10 billion J/ψ events currently collected at BESIII. Nevertheless, these asymmetries utilizing the current BESIII data already permit a measurement of the weak mixing angle with an absolute uncertainty δsw2≈0.09, corresponding to the first determination of sw2 at the J/ψ threshold. In the future, STCFs are estimated to improve this bound by a factor of ∼20 to δsw2≈0.005 within one year based on luminosity rescaling. We also obtain the 95% confidence level upper bounds on the electric dipole moments of the octet baryons, which are of O(10−18)  e cm for BESIII and O(10−19)  e cm for STCFs. These bounds are improved by 2 to 3 orders of magnitude in comparison with the only existing one on Λ from Fermilab. The method discussed in this work also paves a way for a first and direct measurement of the Ξ and Σ electric dipole moments.

Published by the American Physical Society
2024
Enhancing search pipelines for short gravitational-wave transients with Gaussian mixture modeling
Authors: Smith Leigh , Ghosh Sayantan , Sun Jiyoon , Gayathri V. , Heng Ik Siong , Pai Archana 
Published: October 2024

We present an enhanced method for the application of Gaussian mixture modeling (GMM) to the coherent WaveBurst (cWB) algorithm in the search for short-duration gravitational wave (GW) transients. The supervised machine learning method of GMM allows for the multidimensional distributions of noise and signal to be modeled over a set of representative attributes, which aids in the classification of GW signals against noise transients (glitches) in the data. We demonstrate that updating the approach to model construction eliminates bias previously seen in the GMM analysis, increasing the robustness and sensitivity of the analysis over a wider range of burst source populations. The enhanced methodology is applied to the generic burst all-sky short search in the LIGO-Virgo full third observing run (O3), marking the first application of GMM to the 3 detector Livingston-Hanford-Virgo network. For both 2- and 3- detector networks, we observe comparable sensitivities to an array of generic signal morphologies, with significant sensitivity improvements to waveforms in the low quality factor parameter space at false alarm rates of 1 per 100 years. This proves that GMM can effectively mitigate blip glitches, which are one of the most problematic sources of noise for unmodeled GW searches. The cWB-GMM search recovers similar numbers of compact binary coalescence (CBC) events as other cWB postproduction methods, and concludes on no new gravitational wave detection after known CBC events are removed.

Published by the American Physical Society
2024
Neophobia of private labels “Won’t buy it, never tried it!”
Authors: Younis Riham Hassan , Elmeniawy Aiesha 
Published: October 2024

PurposeThis research aims to offer and empirically examine a research model that includes extrinsic cues, attitudes and purchasing intentions for non-private-label (PL) buyers from a developing economy perspective. It also seeks to test the moderating role of neophobia along with gender.Design/methodology/approachData were received from 640 non-PL buyers via a cross-sectional online questionnaire. The study utilised structural equation modelling to examine the relationships among the study constructs.FindingsExtrinsic cues, particularly perceived price and store image, along with attitudes, impact the intention to buy PLs. Furthermore, the moderating role of neophobia was supported.Research limitations/implications This study is limited to the Egyptian retail sector, so its findings reflect the degree of development of PLs in Egypt. Practical implications should be adopted for contexts with identical development levels.Practical implicationsRetail managers should focus on pricing promotions and enhancing their store image to appeal to non-PL shoppers. They should also consolidate their efforts to counteract neophobic tendencies among non-PL shoppers by maximising exposure to PLs and encouraging their trials.Originality/valueThis research offers empirical evidence of the role of neophobia, further enriching our understanding of Middle Eastern consumer behaviour and supporting the implications of extrinsic cues on PL purchase intention for non-PL buyers in developing economies. It supplements earlier research, which mainly focused on developed economies.
“You’re fired”: the influence of heuristic-systematic processing in communication and termination decisions in organizational environments
Authors: Atkins Aaron , Lancaster Alexander L. , Ault Michael K. 
Published: October 2024

PurposeDecisions regarding the termination of organizational members are not only common but also represent difficult actions for managers. Despite their importance and frequency, managers often make or avoid them based on incomplete or faulty decision-making criteria. Previous research suggests that decision-makers are subject to internal influences that play significant roles in their decision-making.Design/methodology/approachUsing a controlled between-groups experimental design, this study, guided by the heuristic-systematic model, tested to what extent decision-makers rely on heuristic cues versus the systematic processing of more relevant information when making termination decisions.FindingsFindings suggest the order in which information is presented influences participants’ decision-making and influences the information-processing structure.Practical implicationsFindings suggest practical considerations for managers, management trainees and others who engage in termination decisions as to potential influencing factors.Originality/valueThis research adds to the understanding of the decision-making process in organizational contexts.
Indonesian mosaic: the essential need for multicultural education
Authors: Mariyono Dwi 
Published: October 2024

Purpose
This desk research critically reviews the existing literature to be dialogued with interviews with several experts on multicultural education in Indonesia to provide input for policymaking and practical strategies. Through a systematic review of academic literature, policy documents and reports, this study aims to provide insights into the challenges and opportunities associated with multicultural education and propose action-based and actionable solutions to promote tolerance, understanding and unity among diverse cultural groups.

Design/methodology/approach
Using a systematic review methodology, this study analyzed existing literature and involved semi-structured interviews with several experts on multicultural education in Indonesia. By searching academic databases and online repositories, relevant literature was synthesized to generate insights into the current state of multicultural education, key challenges and potential solutions. Thematic analysis identified recurring themes and patterns across the literature, allowing for a nuanced understanding of the complexities surrounding multicultural education in Indonesia.

Findings
This research highlights the importance of promoting tolerance and unity among diverse cultural groups in Indonesian education, highlighting curriculum reform, teacher training and community engagement, despite institutional barriers and sociocultural prejudices.

Practical implications
The findings of this study suggest that to maximize the impact of multicultural education in Indonesia, there is a need for comprehensive teacher training programs, equitable resource allocation and localized curricula that reflect Indonesia’s cultural diversity. Policymakers should focus on developing strategies that address the unique challenges of implementing multicultural education in diverse regions, ensuring that all students have access to culturally relevant and inclusive education.

Social implications
The successful implementation of multicultural education has the potential to promote social harmony and inclusivity in Indonesia by fostering a deeper understanding and appreciation of cultural diversity. Addressing the identified challenges and gaps could lead to more cohesive and tolerant communities, reducing social tensions and conflicts rooted in cultural misunderstandings. This research calls for sustained efforts to ensure that multicultural education becomes a cornerstone of Indonesia’s educational system, contributing to the country’s broader goals of unity in diversity.

Originality/value
This research contributes to existing literature on multicultural education by synthesizing insights from diverse academic sources. By systematically reviewing literature, this study offers a comprehensive understanding of challenges and opportunities in Indonesia and provides evidence-based recommendations for policymakers, educators and stakeholders. Emphasizing the importance of promoting tolerance and unity, this study offers practical strategies for realizing these goals in Indonesian society.
Does ESG really matter? Accessing the relevance of ESG in Indian investors’ decision-making dynamics
Authors: Banerjee Sougata , David Rajasekhar 
Published: October 2024

Purpose
Environmental, social and governance (ESG) is becoming an increasingly important non-financial parameter for measuring a company’s valuation. The purpose of this study is to assess the relevance of ESG in Indian investors’ decision-making dynamics.

Design/methodology/approach
This study used an exploratory qualitative research approach based on semi-structured in-depth interviews. A mixed method of purposeful and criterion sampling techniques was used to select 21 participants. Thematic content analysis was performed to analyze the data and understand the relevance of ESG in investors’ decision-making process.

Findings
This study finds that while Indian investors are aware of ESG factors, they prioritize traditional financial metrics like returns and risk over ESG considerations. ESG factors are often treated as secondary, hindered by the lack of standardization in data and ratings, making them difficult to quantify and compare. Additionally, concerns about greenwashing and unreliable ESG information further reduce their importance in investment decisions. The findings of this study highlight the need for reliable ESG data, standardization and increased investor education for better integration.

Research limitations/implications
This is an exploratory study with limited participants. Therefore, the results cannot be generalized to the Indian population. Different sampling criteria, a larger sample size or a quantitative research design approach may increase our understanding of the relevance of ESG.

Practical implications
This study provides insights into the awareness, relative importance and challenges of including ESG in investment decision-making. The results suggest further standardization and improving the awareness and trustworthiness of ESG reporting will help improve its relevance.

Originality/value
To the best of the authors’ knowledge, this study is one of its kind to investigate the awareness, perception and attitudes of Indian investors toward ESG. This study addresses an identified gap in the existing literature, explores the awareness level of ESG among Indian investors and suggests future research directions.
ESG ratings and investment performance: evidence from tech-heavy mutual funds
Authors: Hasnaoui Amir 
Published: October 2024

Purpose
This paper aims to the relationship between environmental, social and governance (ESG) ratings and the investment performance of mutual funds with significant exposure to the technology sector. It aims to explore whether ESG-aligned funds deliver superior financial performance, particularly in terms of risk-adjusted returns and if these funds demonstrate better market timing abilities compared to their lower-rated counterparts.

Design/methodology/approach
The analysis covers a 10-year period from January 2013 to December 2022, focusing on Eurozone-based mutual funds with more than 40% of their assets under management (AUM) invested in technology firms. The sample includes 912 funds, categorized by their ESG ratings (AAA to CCC), using MSCI ratings as the classification metric. The performance evaluation uses risk-adjusted measures such as the Sharpe ratio, Sortino ratio and Jensen’s alpha, along with an assessment of market timing capabilities based on an extended four-factor model.

Findings
The results show that mutual funds with higher ESG ratings consistently outperform their lower-rated peers in both absolute and risk-adjusted returns. These funds also exhibit superior market timing abilities. ESG-aligned funds not only provide a favorable risk-return profile but also enhance the appeal of responsible investment strategies, particularly within the volatile and innovation-driven technology sector. The study reinforces the notion that ESG factors contribute positively to long-term value creation for investors.

Practical implications
The findings are valuable for investors and policymakers aiming to incorporate ESG factors into investment strategies, especially in sectors characterized by rapid technological advancements. The superior performance of ESG-compliant funds highlights the importance of sustainable investing and its potential to align financial returns with broader environmental and social goals.

Originality/value
This study adds to the growing body of literature on ESG investing by specifically focusing on tech-heavy mutual funds in the Eurozone. It offers new insights into how ESG ratings at the fund level, rather than at the firm level, influence investment performance and market timing within the high-growth, high-risk technology sector.