bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing scientific literature reports for pharmacovigilance
Authors: Sorbello Alfred , Ripple Anna , Tonning Joseph , Munoz Monica , Hasan Rashedul , Ly Thomas , Francis Henry , Bodenreider Olivier 
Published: March 2017

Summary
Objectives: We seek to develop a prototype software analytical tool to augment FDA regulatory reviewers’ capacity to harness scientific literature reports in PubMed/MEDLINE for pharmacovigilance and adverse drug event (ADE) safety signal detection. We also aim to gather feedback through usability testing to assess design, performance, and user satisfaction with the tool. Methods: A prototype, open source, web-based, software analytical tool generated statistical disproportionality data mining signal scores and dynamic visual analytics for ADE safety signal detection and management. We leveraged Medical Subject Heading (MeSH) indexing terms assigned to published citations in PubMed/MEDLINE to generate candidate drug-adverse event pairs for quantitative data mining. Six FDA regulatory reviewers participated in usability testing by employing the tool as part of their ongoing real-life pharmacovigilance activities to provide subjective feedback on its practical impact, added value, and fitness for use.
Results: All usability test participants cited the tool’s ease of learning, ease of use, and generation of quantitative ADE safety signals, some of which corresponded to known established adverse drug reactions. Potential concerns included the comparability of the tool’s automated literature search relative to a manual ‘all fields’ PubMed search, missing drugs and adverse event terms, interpretation of signal scores, and integration with existing computer-based analytical tools. Conclusions: Usability testing demonstrated that this novel tool can automate the detection of ADE safety signals from published literature reports. Various mitigation strategies are described to foster improvements in design, productivity, and end user satisfaction.
A Postneoliberal Turn? Variants of the Recent Penal Policy in Argentina
Authors: Sozzo Maximo 
Published: March 2017

This paper analysed the connection between the emergence and consolidation of a postneoliberal political program and alliance – Kirchnerism – and penal policies in Argentina. Three key moments are identified in this recent period. After the experience of an intense punitive turn during the 1990s and early 2000s, Kirchnerist political alliances tried to deploy a progressive political discourse and agenda on penal issues. Nevertheless, this initially coincided with a strong wave of penal populism ‘from below’ that continued the precedent trend towards increasing punitiviness. Since 2005, and for a brief moment, this tendency stopped. However, after that and during the presidencies of Fernandez de Kirchner a more volatile and contradictory scenario was generated. The incarceration rate between 2002 and 2014 in Argentina grew substantially as did the rate of convictions. Meanwhile the percentage of suspended sentences as part of the total convictions and the percentage of custodial sanctions both fell. Especially in relation to incarceration, these levels of change are not as stark as those of the preceding decades. However, the trends persist. Therefore, the question of how to transcend the dynamics of the punitive turn remains a pending and urgent political subject. The article argues the importance of analysing why a punitive turn is interrupted and presents an explanation of it.
The Review of Literature on the Role of Earnings, Cash Flows and Accruals in Predicting of Future Cash Flow
Authors: Mulenga Mwila Joseph , Bhatia Meena 
Published: March 2017

AbstractResearch on the relative ability of accounting information aims in examining the ability of accounting information to predict future cash flow and earnings, based on the assertion given by Financial Accounting Standard Board (FASB) which states that the earnings and its components have a better predictive power than cash flow itself (FASB,1978 para 44). Many studies have been conducted by various researchers but only few of these studies succeed to match with this assertion. This study aims to provide review on the study related to ability of earnings, cash flows from operations and accruals to predict future cash flows where methodology used in this line of research and presentation of empirical results are discussed. The review provides in depth discussion for the purpose of assisting the researchers to get familiarity with line of financial accounting research investigated capital market based accounting research and also as guidance for future researchers.Keywords: Cash flow from operations, Earnings, Accruals, Prediction, Capital Market Based Accounting Research.
Vennootschappen uit het Verenigd Koninkrijk in Nederland na de brexit: gaan zij terug naar het verdomhoekje?
Authors: Kemp B. 
Published: March 2017

Vennootschappen uit het Verenigd Koninkrijk in Nederland na de brexit: gaan zij terug naar het verdomhoekje?
In deze bijdrage wordt stilgestaan bij de gevolgen van een harde brexit voor de vrije vestiging van vennootschappen uit het Verenigd Koninkrijk in Nederland. Daarbij wordt onder meer ingegaan op de Wet op de formeel buitenlandse vennootschappen. Dit wordt ook beschouwd vanuit het perspectief van regulatory competition tussen landen.
Determination of Triazines and Triazoles in Grapes Using Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization High-Resolution Mass Spectrometry
Authors: Mahale Vishal , Singh Ajeet , Phadke Gayatri S , Ghanate Avinash D , Oulkar Dasharath P , Banerjee Kaushik , Panchagnula Venkateswarlu 
Published: March 2017

Abstract
A chromatography-free atmospheric pressure matrix-assisted laser desorption/ionization high-resolution massspectrometry (AP-MALDI HRMS) method is described for the simultaneous and quantitative detection of triazines and triazoles in grapes. The analytes were detected reproducibly with high mass accuracy (mass error within 5 ppm) and further confirmed by collision-induced dissociation fragmentation in tandem MS. The LODs and LOQs forall the analytes were found to be in the nanogram per gram level (15–20 ng/g LOQ). Internal standard–normalized high-resolution accurate mass–extracted (HR-AM) peak intensities of the detected ions were used to generate the concentration response curves. Linearity (with R2 values around 0.99) was obtained for these curves within a concentration range of 20–200 ng/g of the individual analytes. The accuracy and precision of the method were further established using QC samples. Validation and performancecomparison of the AP-MALDI HRMS method with an existing standard method using LC with triple quadrupole MS was carried out (evaluating sensitivity, accuracy, precision, and analysis time) using 20 table-grape field samples after QuEChERS extraction.
Représentations de la maladie mentale et recours à la contrainte
Authors: Guibet Lafaye Caroline 
Published: March 2017

La tradition psychiatrique française est marquée d’une spécificité – la tradition analytique – ayant une présence bien moins forte dans de nombreux autres pays. La psychiatrie dispose en outre de moyens thérapeutiques ignorés par les autres disciplines médicales, en particulier la possibilité d’imposer aux patients, dans certaines conditions, des soins sans leur consentement. Peut-on envisager que les représentations de la maladie mentale, portées par les psychiatres, puissent avoir un lien avec le recours à des formes de contrainte ? Nous tenterons d’apporter une réponse à cette question à partir d’une enquête de type sociologique menée auprès de 90 psychiatres entre 2012 et 2013. Trois types d’attitudes sont majoritairement partagées à l’égard des descriptions de la maladie mentale par l’ensemble des psychiatres néanmoins des corrélations se dégagent entre certaines des interprétations proposées de ces grands types (modèle médical, paradigme individuocentré de type subjectiviste) selon les usages que les médecins ont de la contrainte.
HABILIDADES DE LINGUAGEM E PESSOAL-SOCIAL DE CRIANÇAS DE 0 A 3 ANOS DE IDADE CUIDADAS EM CRECHES
Authors: Rezende Magda A . , Lima Fernanda G. de , Beteli Vivian C. , Santos Jair Lício F. 
Published: March 2017

Supervisão e promoção do desenvolvimento infantil são ações de saúde importantes que devem ser realizadas em creches e pré-escolas. Estas ações podem propiciar o desenvolvimento da criança, especialmente em áreas em que é mais dependente do adulto, tais como as de linguagem e pessoal-social. Nosso objetivo no presente estudo foi avaliar habilidades de linguageme pessoal-social de crianças que freqüentavam 3 creches da cidade de São Paulo. Trinta e três crianças, de 0 a 36 meses, 18 meninos e 15 meninas, foram avaliadas pelo Teste de Triagem de Desenvolvimento de Denver II em 2 momentos, separados entre si por 5 meses. As crianças eram de nível sócio-econômico homogêneo. Os fatores estruturais (proporção adulto/criança, grupos pequenos de crianças) das 3 creches eram adequados. O peso de nascimento variou de 1970 a 4280 g. As classificações obtidas foram unificadas após análise não significante (teste de Fischer). Na segunda avaliação, as habilidades das crianças melhoraram nas duas áreas. Os resultados de cada criança foramemparelhados e analisados com o Teste dos Sinais (risco a=0,05): o resultado foi não significante na linguagem e significante na pessoal-social (p=0,008).Conclui-se que a creche deve ter contribuído para a obtenção destes resultados.
PARÂMETROS ESPAÇO-TEMPORAIS DO ANDAR EM CRIANÇAS OBESAS E COM PESO NORMAL DE ACORDO COM O SEXO
Authors: Kleiner Ana F. R. , Gobbi Lilian T. B. , Menucchi Marcos T. P. , Oliveira Maria D. T. de , Pieruccini-Faria Frederico 
Published: March 2017

Características corporais interferem no desempenho motor. Para analisar os parâmetros espaço-temporais do andar em crianças obesas e de peso normal, por sexo, 23 crianças entre 7 e 10 anos de idade, foram intencionalmente selecionadas e distribuídas em dois grupos: obeso (OB, n=9) e normal (N, n=14). Marcadores reflexivos foram afixados em pontos anatómicos(quinto metatarso, maléolo lateral e calcando). Os participantes andaram sobre uma passarela de 8m de comprimento na velocidade preferida e foram filmados no plano sagital. As variaveis descritivas analisadas foram: comprimento da passada (CP), comprimento da passada normalizado pela estatura (CPN) duração da passada (DP), velocidade da passada (VP), duração da fase de balanço (DFB) e duração da fase de suporte (DFS). Os resultados revelaram que: grupo isoladamente interfere em CPN e DP; sexo isoladamente afeta CP, CPN, VP; grupo e sexo afetam CPN, DFB, DP. Assim, o aumento da massa corporal ocasiona mudanças nos parâmetros espaço- temporais do andar quando sexo é considerado.
A novel Online‐to‐Offline (O2O) model for pre‐exposure prophylaxis and HIV testing scale up
Authors: Anand Tarandeep , Nitpolprasert Chattiya , Trachunthong Deondara , Kerr Stephen J , Janyam Surang , Linjongrat Danai , Hightow‐Weidman Lisa B , Phanuphak Praphan , Ananworanich Jintanat , Phanuphak Nittaya ,   Adam's Love study team
Published: March 2017

AbstractIntroduction: PrEP awareness and uptake among men who have sex with men (MSM) and transgender women (TG) in Thailand remains low. Finding ways to increase HIV testing and PrEP uptake among high‐risk groups is a critical priority. This study evaluates the effect of a novel Adam's Love Online‐to‐Offline (O2O) model on PrEP and HIV testing uptake among Thai MSM and TG and identifies factors associated with PrEP uptake.Methods: The O2O model was piloted by Adam's Love (www.adamslove.org) HIV educational and counselling website. MSM and TG reached online by PrEP promotions and interested in free PrEP and/or HIV testing services contacted Adam's Love online staff, received real‐time PrEP eCounseling, and completed online bookings for receiving services at one of the four sites in Bangkok based on their preference. Auto‐generated site‐ and service‐specific e‐tickets and Quick Response (QR) codes were sent to their mobile devices enabling monitoring and check‐in by offline site staff. Service uptake and participant's socio‐demographic and risk behaviour characteristics were analyzed. Factors associated with PrEP uptake were assessed using multiple logistic regression.Results: Between January 10th and April 11th, 2016, Adam's Love reached 272,568 people online via the PrEP O2O promotions. 425 MSM and TG received eCounseling and e‐tickets. There were 325 (76.5%) MSM and TG who checked‐in at clinics and received HIV testing. Nine (2.8%) were diagnosed with HIV infection. Median (IQR) time between receiving the e‐ticket and checking‐in was 3 (0–7) days. Of 316 HIV‐negative MSM and TG, 168 (53.2%) started PrEP. In a multivariate model, higher education (OR 2.30, 95%CI 1.14–4.66; p = 0.02), seeking sex partners online (OR 2.05, 95%CI 1.19–3.54; p = 0.009), being aware of sexual partners’ HIV status (OR 2.37, 95%CI 1.29–4.35; p = 0.008), ever previously using post‐exposure prophylaxis (PEP) (OR 2.46, 95%CI 1.19–5.09; p = 0.01), and enrolment at Adam's Love clinic compared to the other three sites (OR 3.79, 95%CI 2.06–6.95; p < 0.001) were independently associated with PrEP uptake.Conclusions: Adam's Love O2O model is highly effective in linking online at‐risk MSM and TG to PrEP and HIV testing services, and has high potential to be replicated and scaled up in other settings with high Internet penetration among key populations.
Yttrium and rare earth element partitioning in seawaters from the Bay of Bengal
Authors: Yu Zhaojie , Colin Christophe , Douville Eric , Meynadier Laure , Duchamp‐Alphonse Stéphanie , Sepulcre Sophie , Wan Shiming , Song Lina , Wu Qiong , Xu Zhaokai , Bassinot Frank 
Published: March 2017

AbstractThe dissolved yttrium (Y) and rare earth element (REE) concentrations of seawater samples collected along a north‐south hydrological transect within the Bay of Bengal (BoB) have been analyzed to estimate contributions of the Ganges and Brahmaputra (G‐B) river inputs to the dissolved REE distribution of the Northern Indian Ocean. Surface water masses of the BoB are characterized by Y/Ho ratios (84) intermediate between the G‐B river suspended sediment (41) and water mass from the South Indian Ocean (93). Covariation of MREE (middle REE, Sm) and LREE (light REE, La) concentrations suggests that the dissolved REEs in surface waters (upper 100 m depth) of the BoB (Sm/La = 0.21) appear to derive mainly from the freshwater discharge of the G‐B river system. In contrast, values obtained in the intermediate and deep waters (Sm/La = 0.14) suggest a mixing of dissolved REEs deriving from the release of G‐B river suspended particles (Sm/La = 0.16) and the contribution of Antarctic Bottom Water (AABW) (Sm/La = 0.12). Consequently, we propose that MREE/MREE* ratios in the BoB waters could be an accurate proxy to trace lithogenic inputs from the G‐B river system. The dissolved and particle remineralization Nd fluxes from G‐B river system are calculated to constitute about 9% and 4% of the global dissolved river discharge and “boundary inputs” flux. Our estimation indicates that the massive G‐B river system inputs could greatly alter the dissolved REEs distribution in the BoB and contribute to the dissolved REEs budget in the ocean.
The potential of sedimentary foraminiferal rare earth element patterns to trace water masses in the past
Authors: Osborne Anne H. , Hathorne Ed C. , Schijf Johan , Plancherel Yves , Böning Philipp , Frank Martin 
Published: March 2017

AbstractDissolved rare earth element (REE) concentration data from intermediate and deep seawater form an array characterized by higher middle‐REE enrichments (MREE/MREE*) in the North Atlantic and a progressive increase in heavy‐to‐light REE ratios (HREE/LREE) as water masses age. The REEs in foraminifera are fractionated toward higher MREE/MREE* and lower HREE/LREE relative to seawater. Calculations based on a scavenging model show that the REE patterns in uncleaned core‐top foraminifera resemble those adsorbed onto calcite, particulate organic material, and hydrous ferric oxides but the full extent of the REE fractionation measured in foraminifera was not reproduced by the model. However, differences in the HREE/LREE and MREE/MREE* ratios and the cerium anomaly between ocean basins are preserved and are in agreement with the seawater REE distribution. Under oxic conditions, the HREE/LREE and MREE/MREE* compositions of uncleaned foraminifera at the sediment/seawater boundary are preserved during burial but the cerium anomaly is sensitive to burial depth. In suboxic sedimentary environments, all uncleaned foraminiferal REE concentrations are elevated relative to core‐top values indicating addition of REEs from pore waters. The HREE/LREE ratio is highest when sedimentation rates were greatest and when high Fe/Ca ratios in the uncleaned foraminifera indicate that Fe was mobile. In sediments that have not experienced suboxic conditions during burial, uncleaned foraminifera preserve the seawater signal taken up at the sediment/seawater interface and are therefore suggested to be a suitable archive of changes in the REE signal of past bottom waters.
Differential response of corals to regional mass‐warming events as evident from skeletal Sr/Ca and Mg/Ca ratios
Authors: Clarke Harry , D'Olivo Juan Pablo , Falter James , Zinke Jens , Lowe Ryan , McCulloch Malcolm 
Published: March 2017

AbstractDuring the summer of 2010/2011, a regional marine heat wave resulted in coral bleaching of variable severity along much of the western coastline of Australia. At Ningaloo Reef, a 300 km long fringing reef system and World Heritage site, highly contrasting coral bleaching was observed between two morphologically distinct nearshore reef communities located on either side of the Ningaloo Peninsula: Tantabiddi (∼20% bleaching) and Bundegi (∼90% bleaching). For this study, we collected coral cores (Porites sp.) from Tantabiddi and Bundegi reef sites to assess the response of the Sr/Ca temperature proxy and Mg/Ca ratios to the variable levels of thermal stress imposed at these two sites during the 2010/2011 warming event. We found that there was an anomalous increase in Sr/Ca and decrease in Mg/Ca ratios in the Bundegi record that was coincident with the timing of severe coral bleaching at the site, while no significant changes were observed in the Tantabiddi record. We show that the change in the relationship of Sr/Ca and Mg/Ca ratios with temperature at Bundegi during the 2010/2011 event reflects changes in related coral “vital” processes during periods of environmental stress. These changes were found to be consistent with a reduction in active transport of Ca2+ to the site of calcification leading to a reduction in calcification rates and reduced Rayleigh fractionation of incorporated trace elements.
Detecting negative ions on board small satellites
Authors: Lepri S. T. , Raines J. M. , Gilbert J. A. , Cutler J. , Panning M. , Zurbuchen T. H. 
Published: March 2017

AbstractRecent measurements near comets, planets, and their satellites have shown that heavy ions, energetic neutral atoms, molecular ions, and charged dust contain a wealth of information about the origin, evolution, and interaction of celestial bodies with their space environment. Using highly sensitive plasma instruments, positively charged heavy ions have been used to trace exospheric and surface composition of comets, planets, and satellites as well as the composition of interplanetary and interstellar dust. While positive ions dominate throughout the heliosphere, negative ions are also produced from surface interactions. In fact, laboratory experiments have shown that oxygen released from rocky surfaces is mostly negatively charged. Negative ions and negatively charged nanograins have been detected with plasma electron analyzers in several different environments (e.g., by Cassini and Rosetta), though more extensive studies have been challenging without instrumentation dedicated to negative ions. We discuss an adaptation of the Fast Imaging Plasma Spectrometer (FIPS) flown on MErcury Surface, Space ENvironment, GEochemistry and Ranging (MESSENGER) for the measurement of negatively charged particles. MESSENGER/FIPS successfully measured the plasma environment of Mercury from 2011 until 2015, when the mission ended, and has been used to map multiple ion species (H+ through Na+ and beyond) throughout Mercury's space environment. Modifications to the existing instrument design fits within a 3U CubeSat volume and would provide a low mass, low power instrument, ideal for future CubeSat or distributed sensor missions seeking, for the first time, to characterize the contribution of negative particles in the heliospheric plasmas near the planets, moons, comets, and other sources.
The impact of sedimentary anisotropy on solute mixing in stacked scour‐pool structures
Authors: Bennett Jeremy P. , Haslauer Claus P. , Cirpka Olaf A. 
Published: March 2017

AbstractThe spatial variability of hydraulic conductivity is known to have a strong impact on solute spreading and mixing. In most investigations, its local anisotropy has been neglected. Recent studies have shown that spatially varying orientation in sedimentary anisotropy can lead to twisting flow enhancing transverse mixing, but most of these studies used geologically implausible geometries. We use an object‐based approach to generate stacked scour‐pool structures with either isotropic or anisotropic filling which are typically reported in glacial outwash deposits. We analyze how spatially variable isotropic conductivity and variation of internal anisotropy in these features impacts transverse plume deformation and both longitudinal and transverse spreading and mixing. In five test cases, either the scalar values of conductivity or the spatial orientation of its anisotropy is varied between the scour‐pool structures. Based on 100 random configurations, we compare the variability of velocity components, stretching and folding metrics, advective travel‐time distributions, one and two‐particle statistics in advective‐dispersive transport, and the flux‐related dilution indices for steady state advective‐dispersive transport among the five test cases. Variation in the orientation of internal anisotropy causes strong variability in the lateral velocity components, which leads to deformation in transverse directions and enhances transverse mixing, whereas it hardly affects the variability of the longitudinal velocity component and thus longitudinal spreading and mixing. The latter is controlled by the spatial variability in the scalar values of hydraulic conductivity. Our results demonstrate that sedimentary anisotropy is important for transverse mixing, whereas it may be neglected when considering longitudinal spreading and mixing.