bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative predictive model for the probability of lymph node metastasis in gastric cancer: a retrospective study
Authors: Teng Fei , Zhu Qian , Zhou Xi-Lang , Shi Yi-Bing , Sun Han 
Published: September 2024

BackgroundEffectively diagnosing lymph node (LN) metastasis (LNM) is crucial in determining the condition of patients with gastric cancer (GC). The present study was devised to develop and validate a preoperative predictive model (PPM) capable of assessing the LNM status of individuals with GC.MethodsA retrospective analysis of consecutive GC patients from two centers was conducted over the period from January 2021 to December 2023. These patients were utilized to construct a 289-patient training cohort for identifying LNM-related risk factors and developing a PPM, as well as a 90-patient testing cohort used for PPM validation.ResultsOf the GC patients included in the training cohort, 67 (23.2%) and 222 (76.8%) were respectively LNM negative and positive. Risk factors independently related to LNM status included cT3 invasion (P = 0.001), CT-reported LN (+) (P = 0.044), and CA199 value (P = 0.030). LNM risk scores were established with the following formula: score = -2.382 + 0.694×CT-reported LN status (+: 1; -: 0)+2.497×invasion depth (cT1: 0; cT2: 1; cT3: 2)+0.032×CA199 value. The area under the curve (AUC) values for PPM and CT-reported LN status were 0.753 and 0.609, respectively, with a significant difference between them (P &lt; 0.001). When clinical data from the testing cohort was included in the PPM, the AUC values for the PPM and CT-reported LN status were 0.756 and 0.568 (P &lt; 0.001).ConclusionsThe established PPM may be an effective technique for predicting the LNM status of patients preoperatively. This model can better diagnose LNM than CT-reported LN status alone, this model is better able to diagnose LNM.
The efficacy of curcumin/Qing Dai combination in children with active ulcerative colitis: a multicenter retrospective cohort study
Authors: Nachum Nurit Loberman , Salomon Nir , Yerushalmy-Feler Anat , Weintraub Yael , Yogev Dotan , Granot Maya , Haberman Yael , Ben-Horin Shomron , Weiss Batia 
Published: September 2024

BackgroundCurcumin and Qing Dai (QD) are herbal extracts that recently showed efficacy in treating inflammatory bowel disease (IBD). Since 2016, a combination of curcumin with QD (CurQD) has been employed in our center for management of active ulcerative colitis (UC).ObjectivesWe report the effectiveness and safety of CurQD therapy in children with mild-moderate UC or IBD-unclassified (IBD-U).DesignA multicenter retrospective study.MethodsChildren aged ≤OP18 years who were treated with CurQD during 2017–2021 were included. Disease activity measures were Pediatric UC Activity Index (PUCAI), and fecal calprotectin (FC). The primary outcome was a decrease in PUCAI by ≥10 points, FC normalization (≤100 µg/gr when baseline ≥300 µg/gr) or a ≥ 50% decrease in FC.ResultsOf 30 patients (60% males, mean age 14 ± 3.9 years), 15 (50%), 13 (43%), and 2 (7%) had pancolitis, left-sided colitis and proctitis, respectively. The daily medication dose was 0.5–3 gm QD with 1–4 gm curcumin. Concomitant treatment at induction was corticosteroids (19%), biologics (28%) and 5-aminosalicylic acid (40%). The mean duration of induction was 11.6 weeks [95% confidence interval (CI) 10.2–13.1, range 8–16]. PUCAI decreased from a mean of 31.3 (95% CI 26.6–36.0, range 5–60) to 10.9 (95% CI 7.6–14.4, range 5–35) (n = 26, p &lt; 0.001). FC response and normalization occurred in 11/12 and 7/12 patients, respectively. The median decline in FC was from 749 µg/gm [interquartile range (IQR) 566–1000] to 39 µg/gm (IQR 12–132) (n = 15, p = 0.04). During follow-up (median 8 months, IQR 6–10), 10 patients (33%) flared; five of them regained remission or responded to a treatment change. Of 18 patients treated beyond induction, 12 (67%) achieved clinical response and 10 achieved clinical remission by the end of follow up.ConclusionCurQD may be effective and safe as an add-on option to conventional management, for induction and maintenance in children with mild-moderate UC/IBD-U.
Integrating text mining with network models for successful target identification: in vitro validation in MASH-induced liver fibrosis
Authors: Venhorst Jennifer , Hanemaaijer Roeland , Dulos Remon , Caspers Martien P. M. , Toet Karin , Attema Joline , de Ruiter Christa , Kalkman Gino , Rouhani Rankouhi Tanja , de Jong Jelle C. B. C. , Verschuren Lars 
Published: September 2024

An in silico target discovery pipeline was developed by including a directional and weighted molecular disease network for metabolic dysfunction-associated steatohepatitis (MASH)-induced liver fibrosis. This approach integrates text mining, network biology, and artificial intelligence/machine learning with clinical transcriptome data for optimal translational power. At the mechanistic level, the critical components influencing disease progression were identified from the disease network using in silico knockouts. The top-ranked genes were then subjected to a target efficacy analysis, following which the top-5 candidate targets were validated in vitro. Three targets, including EP300, were confirmed for their roles in liver fibrosis. EP300 gene-silencing was found to significantly reduce collagen by 37%; compound intervention studies performed in human primary hepatic stellate cells and the hepatic stellate cell line LX-2 showed significant inhibition of collagen to the extent of 81% compared to the TGFβ-stimulated control (1 μM inobrodib in LX-2 cells). The validated in silico pipeline presents a unique approach for the identification of human-disease-mechanism-relevant drug targets. The directionality of the network ensures adherence to physiologically relevant signaling cascades, while the inclusion of clinical data boosts its translational power and ensures identification of the most relevant disease pathways. In silico knockouts thus provide crucial molecular insights for successful target identification.
Notoginsenoside R1, a metabolite from Panax notoginseng (Burkill) F.H.Chen, stimulates insulin secretion through activation of phosphatidylinositol 3-kinase (PI3K)/Akt pathway
Authors: Al-Romaiyan Altaf , Barakat Ahmad , Marafie Sulaiman K. , Masocha Willias 
Published: September 2024

BackgroundFor ages, botanical medicine has been used in the treatment of diabetes mellitus (DM). Notoginsenoside R1 (NGR1), a Panax notoginseng (Burkill) F.H.Chen metabolite, has been documented to possess antidiabetic action in vivo. However, its precise molecular mechanism of action is not clear.ObjectivesWe evaluated NGR1’s effects on blood glucose in vivo and then evaluated in vitro whether NGR1 has effects on insulin secretion and the probable molecular pathways involved in NGR1-induced insulin secretion.MethodsDiabetes was induced in mice by streptozotocin. Glucose tolerance test was performed before and after NGR1 was administered intraperitoneally to diabetic animals for 4 weeks. Static and perifusion experiments were performed using isolated female BALB/c mouse islets. Preproinsulin (Ins) mRNA expression was measured using q-PCR. Protein expression of PI3K/Akt pathway was assessed using the fully automated Wes™ capillary-based protein electrophoresis.ResultsTreatment of diabetic mice with NGR1 improved their glucose intolerance. In vitro, NGR1 increased insulin secretion in a concentration-dependent manner. NGR1 initiated the secretion of insulin at 2 mM glucose and augmented glucose-stimulated insulin secretion which was sustained throughout NGR1 perifusion. NGR1-induced insulin secretion was not altered by a voltage gated calcium channel blocker or protein kinase A inhibitor. NGR1 did not significantly modulate Ins mRNA expression. However, NGR1 significantly increased the levels of phospho-Akt and phopho-p-85.ConclusionIn conclusion, this study has shown that NGR1 ameliorates hyperglycemia in diabetic mice. NGR1 has a direct insulin secretagogue activity on mouse islets, stimulates insulin secretion at both basal and postprandial glucose concentrations, and activates PI3K/Akt pathway to induce insulin secretion. These results suggest that NGR1 may provide an alternative therapy to manage DM.
Managers’ perspectives on their role in implementing fall prevention interventions: a qualitative interview study in Norwegian homecare services
Authors: Linnerud Siv , Bjerk Maria , Olsen Nina Rydland , Taraldsen Kristin , Brovold Therese , Kvæl Linda Aimée Hartford 
Published: September 2024

IntroductionThe implementation of fall prevention interventions in homecare services is crucial for reducing falls among older adults and effective leadership could determine success. Norwegian homecare services provide home nursing, rehabilitation, and practical assistance, to residents living in private homes or assisted living facilities. This study aims to explore how managers in Norwegian homecare services experience implementation of fall prevention interventions and how they perceive their roles.MethodsWe conducted 14 semi-structured individual interviews with managers from different levels of homecare services in five city districts. The interviews were transcribed verbatim and reflexive thematic analysis was used to analyze the material.ResultsThe analysis resulted in three main themes: (1) understanding organizational mechanisms to facilitate new practices, (2) practicing positive leadership behavior to facilitate implementation, and (3) demonstrating persistence to sustain implementation. Our results showed the importance of clear leadership across all levels of the organization and the value of devoting time and utilizing existing systems. Managers described using recognition and positive attitudes to motivate employees in the implementation process. They emphasized listening to and involving employees, providing trust, and being flexible. However, the implementation process could be challenging, highlighting the need for managers to be persistent.ConclusionManagers at all levels play an important role in the implementation of fall prevention, but there is a need to define and align their specific roles in the process. Understanding how to use existing systems and influence through positive leadership behavior seem to be vital for success. Recognizing the demanding nature of implementation, managers emphasized the importance of systems for long term support. The study findings may influence how managers in clinical practice engage in the implementation process and inform future researchers about managers’ roles in implementation in homecare services.
Management of Kidney Transplant Outpatients With COVID-19: A Single Center Experience
Authors: Matysková Kubišová Michaela , Dusilová Sulková Sylvie , Moučka Petr , Pokorná Anita , Heislerová Marcela , Guňka Igor , Navrátil Pavel , Pacovský Jaroslav , Malá Alena , Šafránek Roman 
Published: September 2024

Patients undergoing kidney transplant are at risk of severe COVID-19. Our single-center retrospective analysis evaluated the outcomes of kidney transplant outpatients with COVID-19 who were managed with reduced immunosuppression and treatment with molnupiravir. Between January 2022 and May 2023, we included 93 patients (62 men, average age 56 years), serum creatinine 127 (101–153) µmol/L. Molnupiravir was administered, and immunosuppressive therapy was reduced immediately following the confirmation of SARS-CoV-2 infection by PCR, which was 2 (1–3) days after the onset of symptoms. Only three (3.2%) patients required hospitalization, and one patient died. Acute kidney injury was observed in two patients. During the follow-up period of 19 (15–22) months, there was no significant increase in proteinuria, no acute or new chronic graft rejection, and kidney graft function remained stable; serum creatinine was 124 (106–159) µmol/L post-COVID-19 infection and 128 (101–161) µmol/L at the end of the follow-up period. Our results demonstrate that early initiation of molnupiravir treatment combined with a temporary reduction in immunosuppressive therapy results in favorable clinical outcomes in patients with COVID-19, with preservation of good graft function and no episodes of graft rejection.
Progress in Orthotopic Pig Heart Transplantation in Nonhuman Primates
Authors: Längin Matthias , Bender Martin , Schmoeckel Michael , Reichart Bruno 
Published: September 2024

Xenotransplantation of porcine hearts has become a promising alternative to human allotransplantation, where organ demand still greatly surpasses organ availability. Before entering the clinic, however, feasibility of cardiac xenotransplantation needs to be proven, ideally in the life supporting orthotopic pig-to-nonhuman primate xenotransplantation model. In this review, we shortly outline the last three decades of research and then discuss in detail its most recent advances. These include the genetic modifications of donor pigs to overcome hyperacute rejection and coagulation dysregulation, new organ preservation methods to prevent perioperative xenograft dysfunction, experimental immunosuppressive and immunomodulatory therapies to inhibit the adaptive immune system and systemic inflammation in the recipient, growth control concepts to avoid detrimental overgrowth of the porcine hearts in nonhuman primates, and lastly, the avoidance of porcine cytomegalovirus infections in donor pigs. With these strategies, consistent survival of 6–9 months was achieved in the orthotopic xenotransplantation model, thereby fulfilling the prerequisites for the initiation of a clinical trial.
On Symmetrical Equivelar Polyhedra of Type {3, 7} and Embeddings of Regular Maps
Authors: Bokowski Jürgen 
Published: September 2024

A regular map is an abstract generalization of a Platonic solid. It describes a group, a topological cell decomposition of a 2-manifold of type {p, q} with only p-gons, such that q of them meet at each vertex in a circular manner, and we have maximal combinatorial symmetry, expressed by the flag transitivity of the symmetry group. On the one hand, we have articles on topological surface embeddings of regular maps by F. Razafindrazaka and K. Polthier, C. Séquin, and J. J. van Wijk.On the other hand, we have articles with polyhedral embeddings of regular maps by J. Bokowski and M. Cuntz, A. Boole Stott, U. Brehm, H. S. M. Coxeter, B. Grünbaum, E. Schulte, and J. M. Wills. The main concern of this partial survey article is to emphasize that all these articles should be seen as contributing to the common body of knowledge in the area of regular map embeddings. This article additionally provides a method for finding symmetrical equivelar polyhedral embeddings of type {3, 7} based on symmetrical graph embeddings on convex surfaces.
Basic principles and logical-functional model of moderation of interaction between participants of the regional innovation system
Authors: Gorbashko E. A. , Medvedev V. V. 
Published: September 2024

Aim. On the basis of the analysis of the conditions of innovation policy implementation and instructions of the President of Russia on strengthening its realization to build a logical-functional model of moderation of interaction between the participants of the regional innovation system (RIS). Objectives. To consider the organizational principles contributing to the effective moderation of interaction between the authorities of the regional innovation system participants on the basis of innovation policy. Methods. The authors used the methods of analysis and synthesis, as well as governmental normative-legal documents and state standards. Results. A set of basic principles of moderation of interaction between the participants of the regional innovation system is defined: principles of public administration in the aspect of scientific and technological development of the region, principles of innovative development of the economy of the subject of the Russian Federation (RF), principles of effective communication, principles of network-centered management, principles of innovation management. Taking into account the proposed set of basic principles with the use of PDCA-cycle in view of the integration of innovation management in public administration, a two-loop logical-functional model of moderation of the participants of the regional innovation system on the basis of innovation policy is formed. This will allow to develop flexible organizational measures of moderation of interaction between the participants of the innovation system. Conclusions. Aiming at the possibility of developing flexible organizational measures of moderation of interaction between the participants of the innovation system, the logical-functional model of moderation of interaction between the participants of the regional innovation system is proposed, which is distinguished by the complex application of basic principles of public administration in the aspect of scientific and technological development of the region, principles of innovative development of the economy of the subject of the Russian Federation. The principles of effective communication, principles of network-centric management, principles of innovation management and two-circuit configuration of organizational actions of authorities with the application of PDCA-cycle based on the integration of innovation management in public administration are used.
Co-evolutionary-convergent potential of ESG 5.0 as a driver of industrial growth of the Russian economy in a multipolar world
Authors: Babkin A. V. , Shkarupeta E. V. 
Published: September 2024

Aim. To study the coevolutionary-convergent potential formed by synergetic integration of Industry 5.0 technologies and ESG principles, as well as to conceptualize this potential as a driver of industrial growth of the Russian economy in a multipolar world. Objectives. Clarification of the concept of “co-evolutionary-convergent potential” and its implementation in relation to ESG-development version 5.0 in a multipolar world; identification of trends and tendencies in the formation of co-evolutionary-convergent potential of ESG 5.0 on the basis of bibliometric analysis; assessment of opportunities and challenges of the potential impact of co-evolutionary-convergent potential of ESG 5.0 on economic growth in Russia. Methods. The research was conducted using the scientific method of systematic review and meta-analysis according to the PRISMA model. Methods and tools of bibliometric analysis were used, including VosViewer, biblioshiny in R-environment and Lens analytics. ChatGPT-4 model was applied as an intelligent assistant for analyzing and structuring information. Results. The key trends and tendencies of ESG 5.0 co-evolutionary and convergent potential formation were revealed. The analysis of the relationship between the concepts of “Industry 5.0” and “ESG” was carried out, the most productive authors and organizations, as well as the main directions of research were identified. The significant role of ESG 5.0 in stimulating sus-tainable and innovative growth of the Russian economy was confirmed. Conclusions. The coevolutionary and convergent potential of ESG 5.0 is of great importance for promoting industrial growth and sustainable development of the Russian economy. In order to realize this potential, it is necessary to create appropriate infrastructure, adapt the regulatory environment and increase investment in research and development.
Medical employees without medical education: Recruitment options and specifics of personnel management
Authors: Medvedeva E. I. 
Published: September 2024

Aim. To study the possibilities and prospects of attracting specialists without basic medical education (“non-medical”) to medical organizations, as well as to identify specific features of managing this group of employees in the conditions of modernization of the national health care. Objectives. To analyze the necessity of attracting “non-medics”, specific features of organization of their labor activity in the health care system, as well as specific features of management of such specialists in medical organizations; to study the expert opinion of the medical community on attracting “non-medics”; to carry out a comprehensive assessment of the possibilities of attracting “non-medics”; to formulate conclusions relevant for the management of medical organizations regarding the issues of management of personnel with non-medical education. Methods. In the theoretical part of the research the author applied methods of generalized analysis and synthesis, complementarity and system approach, methods of content analysis of scientific sources, as well as statistical data on specialists with non-medical education (form of federal statistical observation (FFSO) No. 30 for 2013–2023). The methodological basis for obtaining primary information was an expert survey based on the application of semi-structured interviews, analysis of cause-effect relationships and systematization of data. The method of visualization of the obtained results was also used. Results. In the conditions of ongoing modernization and optimization of medical organizations, introduction of innovative methods and new standards, as well as the ongoing widespread digitalization, experts confirmed the necessity and validity of attracting “non-medics”. In their opinion, “non-medics” can be “painlessly” transferred technical tasks, functions of a hall manager (administrator), and organizational issues. It is reasonable to include in their functionality the work related to appointment planning and patient routing. Conclusions. The work of medical organizations, management processes and implemented formats of medical care are undergoing significant transformations, which are associated with both new digital opportunities and implemented methods and formats of medical care. This requires dif-ferent approaches not only at the level of general management, but also the involvement of new “non-core” medical specialists who have the appropriate competencies and are able to improve the efficiency of medical organizations and facilitate their work. However, many questions on the involvement of “non-medical professionals” still remain open. The present study is a kind of iteration, will find answers to a number of questions on the basis of the author’s research in the context of the stated topic.
Impostos versus informalidade: uma análise por meio do modelo DSGE
Authors: Gomes Thiago Geovane Pereira , Alderir José Alderir da Silva , Ferreira Francisco Danilo da Silva 
Published: September 2024

Este artigo tem o propósito de avaliar os efeitos dos impostos e da fiscalização sobre o setor informal brasileiro. É adotada estratégia para análise dos canais de transmissão por meio de um modelo DSGE de dois setores e que possibilite a construção de cenários com a redução e simplificação de impostos, como também a redução da fiscalização das firmas informais. O produto formal cresceu em todos os cenários de redução da alíquota dos impostos e, consequentemente, o produto agregado apresentou o mesmo comportamento. Vale salientar a queda da arrecadação tributária, até o quinto período, após a redução da fiscalização do setor informal. E a demanda por trabalho informal caiu após a queda da alíquota dos impostos sobre trabalho e salário.