bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimising an array of Cherenkov telescopes in Australia for the detection of TeV gamma-ray transients
Authors: Lee Simon , Einecke Sabrina , Rowell Gavin , Balazs Csaba , Bellido Jose , Dai Shi , Filipović Miroslav D. , Harvey Violet , McGee Padric , Marinos Peter , Tothill Nicholas , White Martin 
Published: October 2024

Abstract
As TeV gamma-ray astronomy progresses into the era of the Cherenkov Telescope Array (CTA), instantaneously following up on gamma-ray transients is becoming more important than ever. To this end, a worldwide network of Imaging Atmospheric Cherenkov Telescopes has been proposed. Australia is ideally suited to provide coverage of part of the Southern Hemisphere sky inaccessible to H.E.S.S. in Namibia and the upcoming CTA-South in Chile. This study assesses the sources detectable by a small, transient-focused array in Australia based on CTA telescope designs. The TeV emission of extragalactic sources (including the majority of gamma-ray transients) can suffer significant absorption by the extragalactic background light. As such, we explored the improvements possible by implementing stereoscopic and topological triggers, as well as lowered image cleaning thresholds, to access lower energies. We modelled flaring gamma-ray sources based on past measurements from the satellite-based gamma-ray telescope Fermi-LAT. We estimate that an array of four Medium-Sized Telescopes (MSTs) would detect

$\sim$

24 active galactic nucleus flares >5

$\sigma$

per year, up to a redshift of

$z\approx1.5$

. Two MSTs achieved

$\sim$

80–90% of the detections of four MSTs. The modelled Galactic transients were detectable within the observation time of one night, 11 of the 21 modelled gamma-ray bursts were detectable, as were

$\sim$

10% of unidentified transients. An array of MST-class telescopes would thus be a valuable complementary telescope array for transient TeV gamma-ray astronomy.
Expanding the Borders of Atlantic History
Authors: Cañeque Alejandro 
Published: October 2024

Abstract
The field of Atlantic history initially focused exclusively on the Anglo-American North Atlantic, largely ignoring the South Atlantic and Africa. This approach, dominant after World War II, portrayed a “Western civilization” based on North Atlantic liberal values, akin to a postwar Mediterranean. Over time, historians of the Anglo-American Atlantic criticized this narrow focus, recognizing the broader interconnectedness of the Atlantic world. Recent decades have seen a shift, with more historians acknowledging the Atlantic as a complex, interconnected space involving four continents. Particularly notable is the rise of studies on the South Atlantic, especially regarding science and empire in the Iberian world. These studies highlight the significant role of Spain and Portugal, challenging the previously North Atlantic-centered narrative. This research has revealed that the Atlantic world was as much, if not more, shaped by Spanish and Portuguese influences as by English ones. The reviewed works exemplify this shift, focusing on the South Atlantic's imperial entanglements and the African diaspora in the Caribbean.
Low protein uptake during peripuberty impairs the testis, epididymis, and spermatozoa in pubertal and adult Wistar rats
Authors: Frigoli Giovanna Fachetti , Quadreli Débora Hipólito , Santos Dayane Priscila dos , Costa Ivana Regina da , Ferreira Anna Rebeka Oliveira , Peres Maria Natália Chimirri , Ribeiro Maiara Vanusa Guedes , Ceravolo Graziela Scalianti , Mathias Paulo Cezar , Palma-Rigo Kesia , Fernandes Glaura Scantamburlo Alves 
Published: October 2024

Abstract
Protein malnutrition during critical periods poses significant risks to reproductive health. Thus, this study aims to evaluate the immediate and delayed effects of a 30-day low-protein diet on the postnatal development of the male reproductive system. For so, male rats were fed a protein-deficient diet from postnatal day 30–60, followed by evaluations of testis, epididymis, and spermatozoa both at the end of the diet and after a 60-day recovery period. Testicular and epididymal weight was lowered in pubertal animals. Several histological alterations were found in the testis, such as acidophilic cells and vacuoles in the seminiferous epithelium, and sperm production was compromised. In the epididymis, the luminal compartment was diminished, and the stroma was enlarged both in the caput and cauda; in the cauda, the epithelial compartment was enlarged; the transit time of spermatozoa through this organ was diminished. Testosterone production was lowered. Spermatozoa’s motility, mitochondrial activation, and acrosomal integrity were impaired, and several alterations in morphology were observed. After the recovery period, testicular and epididymal weight was restored. Tissue remodulation was observed in the epididymis, but the spermatozoa’s transit time in this organ was not altered. Sperm and testosterone production, spermatozoa motility, mitochondrial activation, and acrosomal integrity were also restored. However, testicular histological alterations and spermatic morphological abnormalities were maintained in protein-restricted animals. Protein restriction during peripuberty impairs the reproductive maturation of pubertal Wistar rats, impairing testicular and epididymal function, with lasting effects even after dietary correction.
Challenges in transitioning from adolescent to Adult Mental Health Services for young adults with ADHD in Italy: an observational study
Authors: Roberti Elisa , Clavenna Antonio , Basso Eleonora , Bravaccio Carmela , Riccio Maria Pia , Pincherle Maurizio , Duca Maddalena , Giordani Claudia , Scarpellini Francesca , Campi Rita , Giardino Michele , Zanetti Michele , Tessarollo Valeria , Costantino Ilaria ,   TransiDEA Group, Bonati Maurizio 
Published: October 2024

Abstract

Aims
Ensuring a successful transition to Adult Mental Health Services (AMHS) is fundamental for attention deficit/hyperactivity disorder (ADHD) patients to prevent adverse scenarios in adults (e.g., psychiatric disorders, substance or alcohol abuse). Yet, most European nations do not have appropriate transition guidelines and still fail to adequately support transition processes. This study aims to enquire about the current transition paths in Italy and the perceived experiences of the patients and their clinicians.

Methods
The present observational study collected 36 interviews with young adults with ADHD who turned 18 between 2017 and 2021. Simultaneously, two questionnaires were filled in by the clinicians (both from paediatric and AMHS) who were involved in their transition paths. These tools collected information about the transition process, the services that cared for the young adults and well-being indicators such as impairment in daily life, employment status and the presence of sentinel events (e.g., critical stage accesses to the emergency room or hospitalizations). Successful and failed referrals were analysed.

Results
A referral to an AMHS was attempted for 16 young adults (8 before age 18 and 8 when turning 18), and 8 patients (22.2% overall) were successfully taken into the care of the AMHS. Twenty patients were not referred since it was deemed unnecessary (N = 6) or because of the lack of specialized services or compliance (N = 14). At the time of the interview, only nine participants were still under AMHS care. Of eleven individuals with a high need for care (identified by the level of impairment, support needs or sentinel events), five were not followed by a mental health professional at the time of the interview.

Conclusions
For the majority of ADHD young adults, a transition path was never started or completed. While this is partly due to mild levels of impairment, in many cases it was difficult to find a service that could care for the adult patient. Only one out of four young adults are successfully transferred to AMHS care. Creating or improving evidence-based transition guidelines should be a priority of the public health system to ensure healthcare for as many patients as possible. The results of this study will converge towards the need for recommendations for the transition of services from adolescence to adulthood for young people with ADHD for Italian clinical practice.
Deertongue (Dichanthelium clandestinum L.) control in golf course naturalized areas
Authors: Godara Navdeep , Rana Sandeep S. , Askew Shawn D. 
Published: October 2024

Abstract
Deertongue is a perennial, warm-season grass, and is problematic in naturalized areas of golf courses due to limited control options. Research was conducted to evaluate several herbicides for deertongue control in naturalized areas consisting primarily of fine fescue. Greenhouse studies assessed 24 herbicide admixtures and indicated that fluazifop, glyphosate, imazapic, and thiencarbazone + iodosulfuron + dicamba (TID) reduced deertongue biomass by >80% at 10 wk after initial treatment (WAIT). Subsequent field trials were conducted on golf course naturalized areas. The first site was on a woodland edge and was partially shaded for 6 h each day, and the second trial site was 50 m away from the woodland edge and not subjected to more than 1 h of daily shade. At 9 WAIT, fluazifop at 420 g ai ha−1 applied once or three times at 3-wk intervals and topramezone at 37 g ai ha−1 applied thrice at 3-wk intervals injured fine fescue by ≤10% at both sites. Glyphosate applied at 1,120 g ae ha−1, imazapic at 105 g ai ha−1, and imazapic at 53 g ai ha−1 tank-mixed with glyphosate at 560 g ae ha−1 injured fine fescue by ≥50% under shaded conditions, whereas glyphosate alone did not injure fine fescue under sunny conditions. Fine fescue was completely recovered by 52 WAIT from injury following herbicide treatments, except for glyphosate-containing treatments at the shaded site and glyphosate + imazapic at both sites. At 52 WAIT, glyphosate-containing treatments and sequential applications of fluazifop controlled deertongue by ≥93% and reduced shoot density to ≤5 shoots m−2 averaged over both sites. Fluazifop at 420 g ha−1 applied thrice at 3-wk intervals selectively controls deertongue with excellent safety to fine fescue. Glyphosate also controls deertongue, but unacceptably injures fine fescue when managed under shaded conditions. Future research will assess how different light intensities influence fine fescue epicuticular wax deposits and associated response to glyphosate.
Predictability of the 2020 Strong Vortex in the Antarctic Stratosphere and the Role of Ozone
Authors: Lim Eun‐Pa , Zhou Linjing , Young Griffith , Abhik S. , Rudeva Irina , Hope Pandora , Wheeler Matthew C. , Arblaster Julie M. , Hendon Harry H. , Manney Gloria L. , Son Seok‐Woo , Oh Jiyoung , Garreaud René D. 
Published: October 2024

AbstractThe Antarctic vortex of October–December 2020 was the strongest on record in the satellite era for the season in the mid‐ to lower stratosphere. However, it was poorly predicted by the Australian Bureau of Meteorology's operational seasonal climate forecast system of that time, ACCESS‐S1, even at a short lead time of a month. Using the current operational forecast system, ACCESS‐S2, we have, therefore, tried to find a primary cause of the limited predictability of this event and conducted forecast sensitivity experiments to understand the potential role of ozone in the event and its associated anomalies of the Southern Annular Mode (SAM) and rainfall over south–eastern Australia and western Patagonia. Here, we show that the 2020 strong vortex event did not follow the canonical dynamical evolution seen in previous strong vortex events in spring but suddenly appeared as a result of the record‐low upward propagating wave activity in September 2020. The ACCESS‐S2 forecasts significantly underestimated the negative wave forcing in September even at zero lead time, irrespective of the ozone configuration, therefore falling short in predicting the record strength of the polar vortex in late spring 2020. Nevertheless, ACCESS‐S2 with prescribed realistic ozone that had large anomalies in the Antarctic stratosphere significantly better predicted the strong vortex and the subsequent positive SAM and related rainfall anomalies over south–eastern Australia and western Patagonia in the austral summer of 2020–21. This highlights the potentially important role of ozone variations for seasonal climate forecasting as a source of long‐lead predictability.
Phase II Study of Irinotecan, Trifluridine/tipiracil (TAS-102) plus Bevacizumab as a Later-line Therapy for Patients with Metastatic Colorectal Cancer (mCRC): a prospective single-center explorative study
Authors: Li Baoqi , Yang Wenwei , Liu Na , Bi Deying , Yang Tingting , Wu Guifu , Sun Yongkun 
Published: October 2024

Abstract
Purpose
To explore the efficacy and safety of the combination of irinotecan, trifluridine/tipiracil (TAS-102), and bevacizumab in a later‐line setting for metastatic colorectal cancer (mCRC) patients.

Patients and methods
This was a single-center, phase II trial. The mCRC patients who are refractory to standard first-line and second-line treatment are eligible. Patients who previously received irinotecan while progressing during maintenance therapy are also eligible. The primary endpoint was the objective response rate (ORR).

Results
Between August 1, 2022, and September 30, 2023, 35 patients were enrolled, and 31 of them were evaluable for efficacy. The ORR was 25.8% (8/31), and the disease control rate (DCR) was 93.5% (29/31). As of April 30, 2024, the median progression-free survival (PFS) was 9.2 months (95% CI 6.285-12.115), whereas the median overall survival (OS) was not reached with the 1-year OS rate of 73.5%. The most common grade 3/4 treatment-related adverse events were neutropenia (34.3%), anemia (17.1%), and thrombocytopenia (8.6%).

Conclusion
Irinotecan, TAS-102 plus bevacizumab regimen preliminarily demonstrated promising efficacy with tolerable toxicity for mCRC patients as later‐line treatment. This regimen warrants further exploration in refractory mCRC patients.
RIP1 inhibition protects retinal ganglion cells in glaucoma models of ocular injury
Authors: Kim Bo Kyoung , Goncharov Tatiana , Archaimbault Sébastien A. , Roudnicky Filip , Webster Joshua D. , Westenskow Peter D. , Vucic Domagoj 
Published: October 2024

Abstract
Receptor-interacting protein 1 (RIP1, RIPK1) is a critical mediator of multiple signaling pathways that promote inflammatory responses and cell death. The kinase activity of RIP1 contributes to the pathogenesis of a number of inflammatory and neurodegenerative diseases. However, the role of RIP1 in retinopathies remains unclear. This study demonstrates that RIP1 inhibition protects retinal ganglion cells (RGCs) in preclinical glaucoma models. Genetic inactivation of RIP1 improves RGC survival and preserves retinal function in the preclinical glaucoma models of optic nerve crush (ONC) and ischemia–reperfusion injury (IRI). In addition, the involvement of necroptosis in ONC and IRI glaucoma models was examined by utilizing RIP1 kinase-dead (RIP1-KD), RIP3 knockout (RIP3-KO), and MLKL knockout (MLKL-KO) mice. The number of RGCs, retinal thickness, and visual acuity were rescued in RIP1-kinase-dead (RIP1-KD) mice in both models, while wild-type (WT) mice experienced significant retinal thinning, RGC loss, and vision impairment. RIP3-KO and MLKL-KO mice showed moderate protective effects in the IRI model and limited in the ONC model. Furthermore, we confirmed that a glaucoma causative mutation in optineurin, OPTN-E50K, sensitizes cells to RIP1-mediated inflammatory cell death. RIP1 inhibition reduces RGC death and axonal degeneration following IRI in mice expressing OPTN-WT and OPTN-E50K variant mice. We demonstrate that RIP1 inactivation suppressed microglial infiltration in the RGC layer following glaucomatous damage. Finally, this study highlights that human glaucomatous retinas exhibit elevated levels of TNF and RIP3 mRNA and microglia infiltration, thus demonstrating the role of neuroinflammation in glaucoma pathogenesis. Altogether, these data indicate that RIP1 plays an important role in modulating neuroinflammation and that inhibiting RIP1 activity may provide a neuroprotective therapy for glaucoma.
Segmentation window of speech information processing in the human auditory cortex
Authors: Hayashi Minoru , Kida Tetsuo , Inui Koji 
Published: October 2024

AbstractHumans perceive continuous speech signals as discrete sequences. To clarify the temporal segmentation window of speech information processing in the human auditory cortex, the relationship between speech perception and cortical responses was investigated using auditory evoked magnetic fields (AEFs). AEFs were measured while participants heard synthetic Japanese words /atataka/. There were eight types of /atataka/ with different speech rates. The durations of the words ranged from 75 to 600 ms. The results revealed a clear correlation between the AEFs and syllables. Specifically, when the durations of the words were between 375 and 600 ms, the evoked responses exhibited four clear responses from the superior temporal area, M100, that corresponded not only to the onset of speech but also to each group of consonant/vowel syllable units. The number of evoked M100 responses was correlated to the duration of the stimulus as well as the number of perceived syllables. The approximate range of the temporal segmentation window limit of speech perception was considered to be between 75 and 94 ms. This finding may contribute to optimizing the temporal performance of high-speed synthesized speech generation systems.
In vitro and computational investigation of antioxidant and anticancer properties of Streptomyces coeruleofuscus SCJ extract on MDA-MB-468 triple-negative breast cancer cells
Authors: Rammali Said , Idir Abderrazak , Aherkou Marouane , Ciobică Alin , Kamal Fatima Zahra , Aalaoui Mohamed El , Rahim Abdellatif , khattabi Abdelkrim , Abdelmajid Zyad , Aasfar Abderrahim , Burlui Vasile , Calin Gabriela , Mavroudis Ioannis , Bencharki Bouchaib 
Published: October 2024

AbstractThis study aimed to explore the antioxidant potential of the ethyl acetate extract of Streptomyces coeruleofuscus SCJ strain, along with its inhibitory effects on the triple-negative human breast carcinoma cell line (MDA-MB-468). The ethyl acetate extract’s total phenolic and flavonoid contents were quantified, and its antioxidant activity was investigated using DPPH (1,1-Diphenyl-2-picrylhydrazyl), ABTS (2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid), and FRAP (Ferric Reducing Antioxidant Power) assays. Furthermore, the cytotoxic effect of the organic extract from Streptomyces coeruleofuscus SCJ on MDA-MB-468 cancer cells was assessed via the crystal violet assay. In tandem, a thorough computational investigation was conducted to explore the pharmacokinetic properties of the identified components of the extract, utilizing the SwissADME and pKCSM web servers. Additionally, the molecular interactions between these components and Estrogen Receptor Beta, identified as a potential target, were probed through molecular docking studies. The results revealed that ethyl acetate extract of SCJ strain exhibited remarkable antioxidant activity, with 39.899 ± 1.56% and 35.798 ± 0.082% scavenging activities against DPPH and ABTS, respectively, at 1 mg/mL. The extract also displayed significant ferric reducing power, with a concentration of 1.087 ± 0.026 mg ascorbic acid equivalents per mg of dry extract. Furthermore, a strong positive correlation (p < 0.0001) between the antioxidant activity, the polyphenol and the flavonoid contents. Regarding anticancer activity, the SCJ strain extract demonstrated significant anticancer activity against TNBC MDA-MB-468 cancer cells, with an inhibition percentage of 62.76 ± 0.62%, 62.67 ± 0.93%, and 58.07 ± 4.82% at 25, 50, and 100 µg/mL of the extract, respectively. The HPLC-UV/vis analysis revealed nine phenolic compounds: gallic acid, sinapic acid, p-coumaric acid, cinnamic acid, trans-fereulic acid, syringic acid, chloroqenic acid, ellagic acid, epicatechin. Streptomyces coeruleofuscus SCJ showed promise for drug discovery, exhibiting antioxidant and anticancer effects.
Visual and ocular surface benefits of mini-scleral contact lenses in patients with chronic ocular graft-versus-host disease (GvHD)
Authors: Keye Philip , Issleib Susanne , Gier Yvonne , Glegola Mateusz , Maier Philip , Böhringer Daniel , Eberwein Philipp , Reinhard Thomas 
Published: October 2024

AbstractGraft-versus-Host disease is a major complication of allogeneic stem cell transplantation. The eyes are a frequently affected organ with a severe dry eye disease being the hallmark manifestation. This retrospective study evaluates the effect of mini-scleral contact lenses on visual acuity, eye-related quality of life and the ocular surface. 62 eyes of 31 patients were included and visual acuity, ocular surface disease index (OSDI) questionnaire results and Oxford grades before and after mini-scleral lens fitting were compared. Median Snellen fraction with mini-scleral lenses was 20/25 (1st 20/30/3rd 20/20) compared to 20/40 median Snellen fraction with spectacles (1st 20/60/3rd 20/25). Median OSDI scores improved from 73 (1st 41.6/3rd 89) before fitting to 27 (1st 14.5/3rd 56) with mini-scleral lenses. Median Oxford grade decreased from 3 before mini-scleral lens fitting (1st 1/3rd 4.75) to 1 after mini-scleral lens fitting (1st 0/3rd 4). Median time of follow up was 717.5 days. Seven patients (22.6%) discontinued therapy with mini-scleral lenses. Mini-scleral lenses are beneficial for most patients with ocular GvHD as they improve visual acuity, eye-related quality of life and the integrity of the corneal epithelium.
Cyclophilin D plays a critical role in the survival of senescent cells
Authors: Protasoni Margherita , López-Polo Vanessa , Stephan-Otto Attolini Camille , Brandariz Julian , Herranz Nicolas , Mateo Joaquin , Ruiz Sergio , Fernandez-Capetillo Oscar , Kovatcheva Marta , Serrano Manuel 
Published: October 2024

AbstractSenescent cells play a causative role in many diseases, and their elimination is a promising therapeutic strategy. Here, through a genome-wide CRISPR/Cas9 screen, we identify the gene PPIF, encoding the mitochondrial protein cyclophilin D (CypD), as a novel senolytic target. Cyclophilin D promotes the transient opening of the mitochondrial permeability transition pore (mPTP), which serves as a failsafe mechanism for calcium efflux. We show that senescent cells exhibit a high frequency of transient CypD/mPTP opening events, known as 'flickering'. Inhibition of CypD using genetic or pharmacologic tools, including cyclosporin A, leads to the toxic accumulation of mitochondrial Ca2+ and the death of senescent cells. Genetic or pharmacological inhibition of NCLX, another mitochondrial calcium efflux channel, also leads to senolysis, while inhibition of the main Ca2+ influx channel, MCU, prevents senolysis induced by CypD inhibition. We conclude that senescent cells are highly vulnerable to elevated mitochondrial Ca2+ ions, and that transient CypD/mPTP opening is a critical adaptation mechanism for the survival of senescent cells.