bluuebunny/crossref_metadata_2025_split huggingface dataset:
Universal, Surfactant‐Free Preparation of Hydrogel Beads on Superamphiphobic and Slippery Surfaces
Authors: Schlaich Christoph , Fan Yue , Dey Pradip , Cui Jiaxi , Wei Qiang , Haag Rainer , Deng Xu 
Published: January 2018

AbstractIn this study a surfactant‐free and shape controllable preparation of microgel beads using super‐repellent surfaces is reported. The extreme hydrophobicity and the interfacial tension of the liquid force the droplet of a gel precursor solution into spherical shape on a superamphiphobic or hemisphere shape on slippery surface. During gelation on the surface, the shape is maintained. Living cells and molecules, which hardly interact with substrate, can be therefore encapsulated in situ. The encapsulation of MC3T3 mouse osteoblast is demonstrated as a proof of concept.
A High‐Energy Density Asymmetric Supercapacitor Based on Fe2O3 Nanoneedle Arrays and NiCo2O4/Ni(OH)2 Hybrid Nanosheet Arrays Grown on SiC Nanowire Networks as Free‐Standing Advanced Electrodes
Authors: Zhao Jian , Li Zhenjiang , Yuan Xiangcheng , Yang Zhen , Zhang Meng , Meng Alan , Li Qingdang 
Published: January 2018

AbstractIn this paper, a novel freestanding core‐branch negative and positive electrode material through integrating trim aligned Fe2O3 nanoneedle arrays (Fe2O3 NNAs) is first proposed with typical mesoporous structures and NiCo2O4/Ni(OH)2 hybrid nanosheet arrays (NiCo2O4/Ni(OH)2 HNAs) on SiC nanowire (SiC NW) skeletons with outstanding resistance to oxidation and corrosion, good conductivity, and large‐specific surface area. The original built SiC NWs@Fe2O3 NNAs is validated to be a highly capacitive negative electrode (721 F g−1 at 2 A g−1, i.e., 1 F cm−2 at 2.8 mA cm−2), matching well with the similarly constructed SiC NWs@NiCo2O4/Ni(OH)2 HNAs positive electrode (2580 F g−1 at 4 A g−1, i.e., 3.12 F cm−2 at 4.8 mA cm−2). Contributed by the uniquely engineered electrodes, a high‐performance asymmetric supercapacitor (ASC) is developed, which can exhibit a maximum energy density of 103 W h kg−1 at a power density of 3.5 kW kg−1, even when charging the device within 6.5 s, the energy density can still maintain as high as 45 W h kg−1 at 26.1 kW kg−1, and the ASC manifests long cycling lifespan with 86.6% capacitance retention even after 5000 cycles. This pioneering work not only offers an attractive strategy for rational construction of high‐performance SiC NW‐based nanostructured electrodes materials, but also provides a fresh route for manufacturing next‐generation high‐energy storage and conversion systems.
Simultaneous Improvement in Efficiency and Stability of Low‐Temperature‐Processed Perovskite Solar Cells by Interfacial Control
Authors: Azmi Randi , Lee Chang‐Lyoul , Jung In Hwan , Jang Sung‐Yeon 
Published: January 2018

AbstractIn most current state‐of‐the‐art perovskite solar cells (PSCs), high‐temperature (≈500 °C)‐sintered metal oxides are employed as electron‐transporting layers (ETLs). To lower the device processing temperature, the development of low‐temperature‐processable ETL materials (such as solution‐processed ZnO) has received growing attention. However, thus far, the use of solution‐processed ZnO is limited because the reverse decomposition reaction that occurs at ZnO/perovskite interfaces significantly degrades the charge collection and stability of PSCs. In this work, the reverse decomposition reaction is successfully retarded by sulfur passivation of solution‐processed ZnO. The sulfur passivation of ZnO by a simple chemical means, efficiently reduces the oxygen‐deficient defects and surface oxygen‐containing groups, thus effectively preventing reverse decomposition reactions during and after formation of the perovskite active layers. Using the low‐temperature‐processed sulfur‐passivated ZnO (ZnO–S), perovskite layers with higher crystallinity and larger grain size are obtained, while the charge extraction at the ZnO/perovskite interface is significantly improved. As a result, the ZnO–S‐based PSCs achieve substantially improved power‐conversion‐efficiency (PCE) (19.65%) and long‐term air‐storage stability (90% retention after 40 d) compared with pristine ZnO‐based PSCs (16.51% and 1% retention after 40 d). Notably, the PCE achieved is the highest recorded (19.65%) for low‐temperature ZnO‐based PSCs.
3D–2D–0D Interface Profiling for Record Efficiency All‐Inorganic CsPbBrI2 Perovskite Solar Cells with Superior Stability
Authors: Zhang Jingru , Bai Dongliang , Jin Zhiwen , Bian Hui , Wang Kang , Sun Jie , Wang Qian , Liu Shengzhong (Frank) 
Published: January 2018

AbstractAll‐inorganic CsPbBrI2 perovskite has great advantages in terms of ambient phase stability and suitable band gap (1.91 eV) for photovoltaic applications. However, the typically used structure causes reduced device performance, primarily due to the large recombination at the interface between the perovskite, and the hole‐extraction layer (HEL). In this paper, an efficient CsPbBrI2 perovskite solar cell (PSC) with a dimensionally graded heterojunction is reported, in which the CsPbBrI2 material is distributed within bulk–nanosheet–quantum dots or 3D–2D–0D dimension‐profiled interface structure so that the energy alignment is optimized in between the valence and conduction bands of both CsPbBrI2 and the HEL layers. Specifically, the valence‐/conduction‐band edge is leveraged to bend with synergistic advantages: the graded combination enhances the hole extraction and conduction efficiency with effectively decreased recombination loss during the hole‐transfer process, leading to an enhanced built‐in electric field, hence a high VOC of as much as 1.19 V. The profiled structure induces continuously upshifted energy levels, resulting in a higher JSC of as much as 12.93 mA cm−2 and fill factor as high as 80.5%, and therefore record power conversion efficiency (PCE) of 12.39%. As far as it is known, this is the highest PCE for CsPbBrI2 perovskite‐based PSC.
Precision medicine based on surgical oncology in the era of genome‐scale analysis and genome editing technology
Authors: Tanaka Shinji 
Published: January 2018

AbstractAccumulated evidence suggests that multiple molecular and cellular interactions promote cancer evolution in vivo. Surgical oncology is of growing significance to a comprehensive understanding of the malignant diseases for therapeutic application. We have analyzed more than 1000 clinical samples from surgically resected tissue to identify molecular biomarkers and therapeutic targets for advanced malignancies. Cancer stemness and mitotic instability were then determined as the essential predictors of aggressive phenotype with poor prognosis. Recently, whole genome/exome sequencing showed a mutational landscape underlying phenotype heterogeneity in caners. In addition, integrated genomic, epigenomic, transcriptomic, metabolic, proteomic and phenomic analyses elucidated several molecular subtypes that cluster in liver, pancreatic, biliary, esophageal and gastroenterological cancers. Identification of each molecular subtype is expected to realize the precise medicine targeting subtype‐specific molecules; however, there are obstacle limitations to determine matching druggable targets or synthetic lethal interactions. Current breakthroughs in genome editing technology can provide us with unprecedented opportunity to recapitulate subtype‐specific pathophysiology in vitro and in vivo. Given a great potential, on‐demand editing system can design actionable strategy and revolutionize precision cancer medicine based on surgical oncology.
Necrotizing enterocolitis associated with Clostridium butyricum in a Japanese man
Authors: Sato Yukio , Kujirai Dai , Emoto Katsura , Yagami Toshiaki , Yamada Taketo , Izumi Manabu , Ano Masaki , Kase Kenichi , Kobayashi Kenji 
Published: January 2018

CaseNecrotizing enterocolitis (NEC) caused by Clostridium butyricum is common in neonates; however, a case of NEC in adults has not been previously reported. An 84‐year‐old Japanese man developed C. butyricum‐related NEC during hospitalization for treatment of stab wounds to the left side of the neck and lower abdomen, without organ damage, and concomitant pneumonia.OutcomeThe patient developed acute onset of emesis accompanied by shock during his admission; partial resection of the small intestine was carried out due to necrosis. Pathologic findings showed mucosal necrosis and extensive vacuolation with gram‐positive rods in the necrotic small intestine. Blood culture tests revealed C. butyricum infection. The patient's condition improved after the surgery. He was moved to a rehabilitation hospital on day 66.ConclusionThis study suggests that hospitalized adult patients who receive antibiotic treatment are at risk for NEC.
Synthese von Zeolithen aus vorkristallisierten Bausteinen: Architektur im Nanomaßstab
Authors: Li Chengeng , Moliner Manuel , Corma Avelino 
Published: January 2018

AbstractSeit den frühen Arbeiten von Barrer in den 1940er Jahren über die Umwandlung natürlicher Mineralien in synthetische Zeolithe ist die Verwendung vorkristallisierter Zeolithe als anorganische strukturdirigierende Agentien für die Synthese anderer kristalliner Zeolithe mit verbesserten physikalisch‐chemischen Eigenschaften zu einem wichtigen Forschungsgebiet geworden. Insbesondere in den letzten Jahren die dabei die Entwicklung neuer industrieller Katalysatoren gelungen. In diesem Aufsatz beschreiben wir, wie das Vorhandensein bestimmter kristalliner Fragmente im Synthesemedium, wie z. B. kleiner Sekundärbausteine (SBUs) oder geschichteter Teilstrukturen, nicht nur die Kristallisation anderer Zeolithe begünstigt, die ähnliche SBUs oder Schichten aufweisen, sondern auch die gezielte Steuerung wichtiger Parameter ermöglicht, die die katalytische Aktivität beeinflussen (chemische Zusammensetzung, Kristallgröße, Porosität usw.). Aktuelle Fortschritte bei der Herstellung von 3D‐ und 2D‐Zeolithen durch Impfen und Zeolith‐Zeolith‐Umwandlungsvorgänge werden ausführlich besprochen, einschließlich der Herstellung mit oder ohne Beteiligung organischer strukturdirigierender Agentien (OSDAs). Ziel ist es, allgemeine Leitlinien für die Entwicklung wirkungsvollerer zukünftiger Syntheseansätze für Zeolithe auszuarbeiten.
Precisely Tailoring Upconversion Dynamics via Energy Migration in Core–Shell Nanostructures
Authors: Zuo Jing , Sun Dapeng , Tu Langping , Wu Yanni , Cao Yinghui , Xue Bin , Zhang Youlin , Chang Yulei , Liu Xiaomin , Kong Xianggui , Buma Wybren Jan , Meijer Evert Jan , Zhang Hong 
Published: January 2018

AbstractUpconversion emission dynamics have long been believed to be determined by the activator and its interaction with neighboring sensitizers. Herein this assumption is, however, shown to be invalid for nanostructures. We demonstrate that excitation energy migration greatly affects upconversion emission dynamics. “Dopant ions’ spatial separation” nanostructures are designed as model systems and the intimate link between the random nature of energy migration and upconversion emission time behavior is unraveled by theoretical modelling and confirmed spectroscopically. Based on this new fundamental insight, we have successfully realized fine control of upconversion emission time behavior (either rise or decay process) by tuning the energy migration paths in various specifically designed nanostructures. This result is significant for applications of this type of materials in super resolution spectroscopy, high‐density data storage, anti‐counterfeiting, and biological imaging.
Building Zeolites from Precrystallized Units: Nanoscale Architecture
Authors: Li Chengeng , Moliner Manuel , Corma Avelino 
Published: January 2018

AbstractSince the early reports by Barrer in the 1940s on converting natural minerals into synthetic zeolites, the use of precrystallized zeolites as crucial inorganic directing agents to synthesize other crystalline zeolites with improved physicochemical properties has become a very important research field, allowing the design, particularly in recent years, of new industrial catalysts. This Review highlights how the presence of some crystalline fragments in the synthesis media, such as small secondary building units (SBUs) or layered substructures, not only favors the crystallization of other zeolites with similar SBUs or layers, but also permits control over important parameters affecting their catalytic activity (chemical composition, crystal size, or porosity, etc.). Recent advances in the preparation of 3D and 2D zeolites through seeding and zeolite‐to‐zeolite transformation processes will be discussed extensively in this Review, including their preparation in the presence or absence of organic structure‐directing agents (OSDAs). The aim is to introduce general guidelines for more efficient approaches for target zeolites.
Direct Room‐Temperature Conversion of Methane into Protonated Formaldehyde: The Gas‐Phase Chemistry of Mercury among the Zinc Triad Oxide Cations
Authors: Yue Lei , Zhou Shaodong , Sun Xiaoyan , Schlangen Maria , Schwarz Helmut 
Published: January 2018

AbstractIn thermal reactions of methane with diatomic metal oxides [MO].+ of the zinc triad (M=Zn, Cd, Hg), protonated formaldehyde [CH2OH]+ is generated as the major product only for the [HgO].+/CH4 couple. Mechanistic insight is provided by high‐level quantum‐chemical calculations, and relativistic effects are suggested to be the root cause for the unexpected thermal production of [CH2OH]+ from [HgO].+/CH4.
Porphyrin‐Based Symmetric Redox‐Flow Batteries towards Cold‐Climate Energy Storage
Authors: Ma Ting , Pan Zeng , Miao Licheng , Chen Chengcheng , Han Mo , Shang Zhenfeng , Chen Jun 
Published: January 2018

AbstractElectrochemical energy storage with redox‐flow batteries (RFBs) under subzero temperature is of great significance for the use of renewable energy in cold regions. However, RFBs are generally used above 10 °C. Herein we present non‐aqueous organic RFBs based on 5,10,15,20‐tetraphenylporphyrin (H2TPP) as a bipolar redox‐active material (anode: [H2TPP]2−/H2TPP, cathode: H2TPP/[H2TPP]2+) and a Y‐zeolite–poly(vinylidene fluoride) (Y‐PVDF) ion‐selective membrane with high ionic conductivity as a separator. The constructed RFBs exhibit a high volumetric capacity of 8.72 Ah L−1 with a high voltage of 2.83 V and excellent cycling stability (capacity retention exceeding 99.98 % per cycle) in the temperature range between 20 and −40 °C. Our study highlights principles for the design of RFBs that operate at low temperatures, thus offering a promising approach to electrochemical energy storage under cold‐climate conditions.
The [U2F12]2− Anion of Sr[U2F12]
Authors: Scheibe Benjamin , Pietzonka Clemens , Mustonen Otto , Karppinen Maarit , Karttunen Antti J. , Atanasov Mihail , Neese Frank , Conrad Matthias , Kraus Florian 
Published: January 2018

AbstractThe D2h‐symmetric dinuclear complex anion [U2F12]2− of pastel green Sr[U2F12] shows a hitherto unknown structural feature: The coordination polyhedra around the U atoms are edge‐linked monocapped trigonal prisms, the UV atoms are therefore seven‐coordinated. This leads to a U–U distance of 3.8913(6) Å. A weak UV–UV interaction is observed for the dinuclear [U2F12]2− complex and described by the antiferromagnetic exchange Jexp of circa −29.9 cm−1. The crystalline compound can be easily prepared from SrF2 and β‐UF5 in anhydrous hydrogen fluoride (aHF) at room temperature. It was studied by means of single crystal X‐ray diffraction, IR, Raman and UV/VIS spectroscopy, magnetic measurements, and by molecular as well as by solid‐state quantum chemical calculations.
Progress in Tobacco Control in Singapore: Lessons and Challenges in the Implementation of the Framework Convention on Tobacco Control
Authors: Amul Gianna Gayle Herrera , (Pangestu) Pang Tikki 
Published: January 2018

AbstractSingapore has implemented tobacco control policies since the 1970s, more than three decades before it became party to the World Health Organization (WHO) Framework Convention on Tobacco Control—the first evidence‐based global health treaty in 2005. The country's stringent policies have resulted in a 13 per cent adult smoking prevalence rate, one of the lowest in the world. This article reviews how a mix of demand‐ and supply‐reduction measures with extensive regulation and stringent enforcement has contributed to Singapore's reputation as the ‘most hostile environment’ for tobacco companies. Its tobacco control policies can offer lessons for more effective tobacco control among its neighbouring countries.
Brief Report: Cancer Immunotherapy in Patients With Preexisting Rheumatic Disease: The Mayo Clinic Experience
Authors: Richter Michael D. , Pinkston Olga , Kottschade Lisa A. , Finnes Heidi D. , Markovic Svetomir N. , Thanarajasingam Uma 
Published: January 2018

ObjectiveTo determine the risk of rheumatic disease flare and adverse effects in patients with preexisting rheumatic disease who were receiving immune checkpoint inhibitor (ICI) therapy.MethodsA retrospective medical record review was performed to identify all patients who received ICI therapy at Mayo Clinic in Rochester, Minnesota between 2011 and 2016 (~700 patients). Those with a preexisting rheumatic disease were identified using specific diagnostic codes.ResultsSixteen patients were identified (81% female, median age 68.5 years). The most common rheumatic diseases were rheumatoid arthritis (n = 5), polymyalgia rheumatica (n = 5), Sjögren's syndrome (n = 2), and systemic lupus erythematosus (n = 2). Seven patients were receiving immunosuppressive therapy or glucocorticoids for their rheumatic disease at the time of initiation of the ICI. The primary malignancies were melanoma (n = 10), pulmonary (n = 4), or hematologic (n = 2). In most cases, ICIs were offered only after failure of several other therapies. Immune‐related adverse effects (IRAEs) occurred in 6 patients, and all were treated successfully with glucocorticoids and discontinuation of the ICI therapy. There were no significant differences in time from cancer diagnosis to immunotherapy, duration of immunotherapy, age, or sex between the patients with and those without IRAEs.ConclusionTo our knowledge, this represents the largest single‐center cohort of patients with rheumatic diseases who were exposed to modern cancer immunotherapy. Only a minority of these patients experienced a flare of their preexisting rheumatic disease or any other IRAE.
Highly Efficient Glycerol Acetalization over Supported Heteropoly Acid Catalysts
Authors: Chen Lin , Nohair Bendaoud , Zhao Dongyuan , Kaliaguine Serge 
Published: January 2018

AbstractThe acetalization of glycerol with acetone to yield solketal was catalyzed by Cs2.5H0.5PW12O40 (Cs2.5) supported on mesoporous silica under mild conditions. It gave a high glycerol conversion and selectivity to the targeted product even at room temperature (23 °C). We studied the use of both bulk and supported Cs2.5 as catalysts in another highly efficient glycerol acetalization reaction with paraformaldehyde, which gave much higher activity than with formaldehyde solution. For the reaction with acetone, the supported Cs2.5 showed a higher activity than the bulk material because of the high surface area of the mesoporous support. Interestingly, the supported Cs2.5 gave a lower conversion than the bulk for the reaction with paraformaldehyde. This is probably because of the high viscosity of the reaction system with the solid reagent paraformaldehyde. Overall, there is a complex relationship between catalyst, reaction conditions, which include the molar ratio of reactants and temperature, reaction mechanism and thermodynamics that affects the achieved activity and byproduct formation. A discussion about these interactions is included for each reaction.
Crystallization Behavior of Glycine Molecules with Electrolytic Dissociation on Charged Silica Gel Particles
Authors: Deki Yuto , Kadota Kazunori , Onda Saori , Tozuka Yuichi , Shimosaka Atsuko , Yoshida Mikio , Shirakawa Yoshiyuki 
Published: January 2018

AbstractThe surface charge of metal oxides in the solution phase may be a driving force for crystallization. Composite particles were prepared using the principle of heterogeneous nucleation on a metal surface with varying charge density. The electrical properties of the silica gel particles in an electrolyte solution were controlled by the pH, and the zero charge point and charge density of the silica gel particles were determined by titration. The morphology of the glycine particles on the silica gel surface depended on the electrical properties of the silica gel particle, resulting in alteration of the glycine polymorph. Powder X‐ray diffraction showed that γ‐glycine was present at low pH, and α‐glycine, at high pH. The polymorphism arose from the abundance ratio of the solute ions and the solution structure.
All‐in‐one: The dream and reality of molecular cytopathology testing on routine lung cancer smears
Authors: Troncone Giancarlo 
Published: January 2018

If cytopathologists are used to dedicating 1 or more fine‐needle aspiration passes to prepare a tumor‐representative cell block, the testing laboratory may strongly rely on anaplastic lymphoma kinase (ALK), ROS proto‐oncogene 1, receptor tyrosine kinase (ROS1), and programmed death‐ligand 1 (PD‐L1) immunocytochemistry assays. Conversely, when sample procurement and diagnostic interpretation are based primarily on smeared material, cytopathologists should promote, in conjunction with the molecular team, ALK and ROS1 RNA‐based testing approaches on smears, saving the cell block only for PD‐L1 staining.See also pages 158‐69.
Simultaneous detection of single‐nucleotide variant, deletion/insertion, and fusion in lung and thyroid carcinoma using cytology specimen and an RNA‐based next‐generation sequencing assay
Authors: Guseva Natalya V. , Jaber Omar , Stence Aaron A. , Sompallae Krishnaveni , Bashir Amani , Sompallae Ramakrishna , Bossler Aaron D. , Jensen Chris S. , Ma Deqin 
Published: January 2018

BACKGROUNDMolecular testing for epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) and ROS proto‐oncogene 1, receptor tyrosine kinase (ROS1) fusion is routinely performed in patients with stage IV lung adenocarcinoma to assess their eligibility for targeted therapy. Fine‐needle aspiration (FNA)‐derived material frequently is the only pathologic material available. The identification of genomic aberrations in thyroid nodules from FNA smears may help stratify cancer risk and spare patients from a second surgery. In the current study, the authors tested nucleic acid extracted from the cytology smears of lung and thyroid carcinomas for simultaneous detection of single‐nucleotide variant, insertion/deletion, and gene fusion using an RNA‐based next‐generation sequencing assay.METHODSA total of 27 cases (17 lung and 10 thyroid carcinomas, the majority of which had known variants) were tested. Areas of interest were scrapped from stained smears using a scalpel. Total nucleic acid was extracted. Gene fusion and mutational analysis was performed using the Comprehensive Thyroid and Lung FusionPlex Assay. Data were analyzed using the analysis pipeline provided by the vendor. Eleven cases with available formalin‐fixed, paraffin‐embedded (FFPE) tissue were tested in parallel.RESULTSGene fusions were detected in 6 cases; common single‐nucleotide variants in EGFR, RAS, and BRAF in 14 cases; and in‐frame deletions within EGFR in 3 cases. A concordance rate of 100% was observed between FNA and FFPE tissue.CONCLUSIONSCytology preparations can be a reliable source for the detection of both DNA and RNA aberrations. The ability to simultaneously detect multiple types of genomic variants is crucial for patients with advanced cancer and maximizes the usefulness of cytology specimens. Cancer Cytopathol 2018;126:158‐69. © 2018 American Cancer Society.