bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dacomitinib versus gefitinib for the first-line treatment of advanced EGFR mutation positive non-small cell lung cancer (ARCHER 1050): A randomized, open-label phase III trial.
Authors: Mok Tony , Cheng Ying , Zhou Xiangdong , Lee Ki Hyeong , Nakagawa Kazuhiko , Niho Seiji , Tsuji Fumito , Rosell Rafael , Corral Jaime Jesus , Migliorino Maria Rita , Pluzanski Adam , Linke Rolf Gerhard , Sbar Eric , Wang Tao , Wu Yi-Long 
Published: June 2017

LBA9007 Background: Dacomitinib is a 2nd generation EGFR TKI with encouraging clinical activity as 1st-line therapy in patients with EGFR-activating mutation positive advanced NSCLC (Jänne, Lancet Oncol 2014). We performed the first randomized phase III trial, currently ongoing, comparing dacomitinib (D) with gefitinib (G) as 1st-line therapy (1L) (NCT01774721). Methods: Patients (pts) with newly diagnosed stage IIIB/IV/ recurrent NSCLC harboring an EGFR- activating mutation (exon 19 del or exon 21 L858R mu +/- exon 20 T790M mu) were randomized 1:1 to D 45 mg PO QD or G 250mg PO QD; stratification was by race and EGFR mutation subtype. The primary endpoint was PFS per blinded independent review (IRC) analyzed by Kaplan-Meier method with log-rank test and Cox model. Secondary endpoints included: overall survival, objective response rate (ORR), duration of response (DR), PFS per Investigator (INV), time to treatment failure (TTF), restricted mean survival time (RMST) for PFS, safety and patient-reported outcomes (PROs). Results: The ITT population included 452 pts with baseline characteristics fairly well balanced between the arms. ORR per IRC was similar between arms (75% [95% CI: 69, 80] for D and 72% [95% CI: 65, 77]; 2-sided p-value = 0.39; OS is not mature. The most commonly reported grade 3 adverse events with dacomitinib were dermatitis acneiform (13.7%) and diarrhea (8.4%) and with gefitinib ALT (8.5%); no new safety signals were identified. Conclusions: ARCHER 1050 was the first phase III head-to-head study of EGFR TKIs and demonstrated statistically significant and clinically meaningful improvement in efficacy of D vs. G in 1L NSCLC pts with EGFR-activating mutations with a manageable safety profile, to offer a new 1L treatment option. Clinical trial information: NCT01774721. [Table: see text]
The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones
Authors: Szikora Szilárd , Földi István , Tóth Krisztina , Migh Ede , Vig Andrea , Bugyi Beáta , Maléth József , Hegyi Péter , Kaltenecker Péter , Sanchez-Soriano Natalia , Mihály József 
Published: June 2017

ABSTRACT
Directed axonal growth depends on correct coordination of the actin and microtubule cytoskeleton in the growth cone. However, despite the relatively large number of proteins implicated in actin−microtubule crosstalk, the mechanisms whereby actin polymerization is coupled to microtubule stabilization and advancement in the peripheral growth cone remained largely unclear. Here, we identified the formin Dishevelled-associated activator of morphogenesis (DAAM) as a novel factor playing a role in concerted regulation of actin and microtubule remodeling in Drosophila melanogaster primary neurons. In vitro, DAAM binds to F-actin as well as to microtubules and has the ability to crosslink the two filament systems. Accordingly, DAAM associates with the neuronal cytoskeleton, and a significant fraction of DAAM accumulates at places where the actin filaments overlap with that of microtubules. Loss of DAAM affects growth cone and microtubule morphology, and several aspects of microtubule dynamics; and biochemical and cellular assays revealed a microtubule stabilization activity and binding to the microtubule tip protein EB1. Together, these data suggest that, besides operating as an actin assembly factor, DAAM is involved in linking actin remodeling in filopodia to microtubule stabilization during axonal growth.
Social support as a determinant of life satisfaction in pregnant women and women after surgical delivery
Authors: Gebuza Grażyna , Kaźmierczak Marzena , Mieczkowska Estera , Gierszewska Małgorzata 
Published: June 2017

Cel pracyCelem badania było ustalenie czy wsparcie społeczne otrzymane przez kobiety w III trymestrze ciąży i okresie poporodowym różni się istotnie ze względu na metodę zakończenia ciąży oraz czy istnieje różnica w zadowoleniu z życia badanych kobiet.MetodaW badaniu brało udział 195 kobiet w trzecim trymestrze ciąży i 182 tych samych kobiet po porodzie. Wykorzystano Berlińską Skalę Otrzymanego Wsparcia Społecznego BSSS oraz Skalę Zadowolenia z Życia SWLS.WynikiJuż w trzecim trymestrze ciąży kobiety, którym wykonano później cięcie cesarskie otrzymały istotnie więcej każdego rodzaju wsparcia społecznego niż kobiety, które rodziły fizjologicznie. W okresie poporodowym, kobiety po cięciu cesarskim otrzymały istotnie więcej tylko wsparcia instrumentalnego. Nie stwierdzono różnicy istotnej statystycznie w zadowoleniu z życia w badanych grupach kobiet.WnioskiWyniki tego badania wskazują, że cięcie cesarskie nie zapewnia lepszego zadowolenia z życia. Wsparcie instrumentalne odgrywa istotną rolę w zaspokajaniu opiekuńczych potrzeb kobiet po cięciu cesarskim w okresie połogu. To badanie pokazuje jakiego wsparcia potrzebują kobiety, wskazuje również na znaczącą rolę ojców podczas narodzin dziecka.
The Effect of Retail Distribution on Sales of Alcoholic Beverages
Authors: Friberg Richard , Sanctuary Mark 
Published: June 2017

We use monthly sales of all wines, beer, and spirits sold between 2006 and 2011 by Sweden’s retail monopoly on alcohol to estimate the causal effect of retail distribution on market share by volume at the product level. Products are defined at the level of the stock-keeping unit. Two institutional features are key to identifying the causal effect: First, the monopolist uses four levels of retail distribution; a change in retail distribution is therefore associated with a discrete shift in the number of stores that carry a product in a given month. Second, the retailer is legally bound and monitored by the European Union to ensure that it acts in a non-discriminatory manner with all its suppliers. These features allow us to rule out many possible confounding factors in estimating the effect of distribution on sales volume. We find large and statistically significant effects from changes in retail distribution on market share by volume across all levels of retail distribution. The associated volume elasticity of retail distribution is convex; the wider the retail distribution the greater the marginal volume increase from further widening. In this market, wider distribution means reaching stores with successively smaller assortment. Our results indicate that the smaller assortment in smaller stores, coupled with a low resistance to compromise, is the main reason for the convex pattern. In other words, convexity appears to be generated by products achieving “a larger share of a smaller pie” as retail distribution expands. Data are available at https://doi.org/10.1287/mksc.2017.1038 .
Can We Trust Online Physician Ratings? Evidence from Cardiac Surgeons in Florida
Authors: Lu Susan F. , Rui Huaxia 
Published: June 2017

Despite heated debate about the pros and cons of online physician ratings, little systematic work has examined the correlation between physicians’ online ratings and their actual medical quality. Using the ratings of cardiac surgeons at RateMDs and the patient outcomes of coronary artery bypass graft surgeries in the 2013 Florida Hospital Inpatient Discharge Data, we investigate whether online ratings are informative about physicians’ medical quality. To account for potentially nonrandom matchings of patients of different severity levels to surgeons of different rating categories, we focus on patients who arrived through the emergency department and explicitly consider how observed and unobserved patient health conditions jointly affect the matching arrangements and surgical outcomes. Both reduced form and two-stage estimation results show that, compared with surgeons rated four stars or higher, or those without rating information, lower rated surgeons are associated with significantly higher in-hospital mortality rates. Our findings suggest that online physician ratings could be a valuable information source for patients to learn about physician quality, at least for cardiac surgeons, a specialty for which treatment outcomes are relatively observable to patients and their family members. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2741 . This paper was accepted by Anandhi Bharadwaj, information systems.
Efficient Ignorance: Information Heterogeneity in a Queue
Authors: Hu Ming , Li Yang , Wang Jianfu 
Published: June 2017

How would the growing prevalence of real-time delay information affect a service system? We consider a single-server queueing system where customers arrive according to a Poisson process and the service time follows an exponential distribution. There are two streams of customers, one informed about real-time delay and the other uninformed. The customers’ uninformed behavior may be due to information ignorance or rational behavior in the presence of an information fee. We characterize the equilibrium behavior of customers with information heterogeneity and investigate how the presence of a larger fraction of informed customers affects the system performance measures, i.e., throughput and social welfare. We show that the effects of growing information prevalence on system performance measures are determined by the equilibrium joining behavior of uninformed customers. Perhaps surprisingly, we find that throughput and social welfare can be unimodal in the fraction of informed customers. In other words, some amount of information heterogeneity in the population can lead to more efficient outcomes, in terms of the system throughput or social welfare, than information homogeneity. For example, under a very mild condition, throughput in a system with an offered load of 1 will always suffer if there are more than 58% of informed customers in the population. Moreover, it is shown that for an overloaded system with offered load sufficiently higher than 1, social welfare always reaches its maximum when some fraction of customers is uninformed of the congestion level in real time. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2747 . This paper was accepted by Gad Allon, operations management.
How Much Do Industry, Corporation, and Business Matter, Really? A Meta-Analysis
Authors: Vanneste Bart S. 
Published: June 2017

The academic field of strategy seeks to explain differences in firm performance. A consensus exists that industry, corporate, and business effects together account for most performance differences, but there is debate over how much each factor explains. Previous studies have used three different effect size measures: sum of squares, variance, or standard deviation. These measures yield different results for a given sample, which precludes direct comparison. Using simulation analysis, I show that the sum-of-squares measure is sensitive to sample dimensions (e.g., the number of industries, the number of businesses per industry). Using 25 samples from nine studies (N = 212,112), I find that this sensitivity is strong in practice: knowing only the dimensions of a sample is sufficient to predict well the sum-of-squares measure. A meta-analysis is conducted using the variance and standard deviation measures instead (18 samples from 16 studies, N = 225,183). With the variance measure, the effect sizes are 0.08 for industry, 0.14 for corporate, and 0.36 for business; effect sizes with the standard deviation measure are 0.28 for industry, 0.36 for corporate, and 0.59 for business. Thus business effects have about twice the explanatory power of corporate effects, and corporate effects explain somewhat more than do industry effects. The online appendix is available at https://doi.org/10.1287/stsc.2017.0029 .
Evolving Definitions of Autism and Impact on Eligibility for Developmental Disability Services: California Case Example
Authors: Williams Marian E. , Wheeler Barbara Y. , Linder Lisa , Jacobs Robert A. 
Published: June 2017

Abstract
When establishing eligibility for developmental disability (DD) services, definitions of specific diagnostic conditions, such as autism, impact policy. Under the Medicaid home and community-based waiver program, states have discretion in determining specific program or service eligibility criteria, the nature of supports to be provided, and the number of individuals to be served. Individuals with DD, their families, and advocates have pushed to expand eligibility and improve the quality of services and supports received. This article uses a California legal case to explore the impact on individuals seeking eligibility for DD services when states rely on evolving diagnostic criteria for autism spectrum disorder. Recommendations are made for a more equitable and consistent approach to disability eligibility determination.
‘Delightfully depressing’: Death/doom metal music world and the emotional responses of the fan
Authors: Yavuz M. Selim 
Published: June 2017

Abstract
Death/doom metal music, from both sides of the name, usually occupies itself with the darker spectrum of human emotion. Depression, melancholy and death are common themes in the music and in the reception of this music from an outsider point of view. In line with symbolic interactionism, these emotional responses differ significantly when they originate from a well-socialized member of this music world. This suggests that one may think of emotional responses as conventions of a music world. Common responses provide an emotional repertoire for members, and furthermore they become an adhesive for the community. In this article, I discuss my research of the fans of death/doom metal and explore the ways in which the fan responds to the music while contemplating on how death/doom functions in the lives of these fans.
Textural applications of power chords in Scandinavian death metal
Authors: Kazdan Alanna 
Published: June 2017

Abstract
The purpose of this research is to explore a concretely analytical approach to power chords and harmonic structure in Scandinavian death metal. While often approached from sociological or anthropological perspectives, traditional music theory tends to be overlooked in the study of metal. While many harmonic progressions in death metal do err on the side of being more simplistic in nature, the textural changes and unexpected harmonic shifts help to create recognizable idioms of the genre. Using thorough harmonic and melodic analyses of Viking metal, melodic death metal and folk metal examples, conclusions can be drawn about the similarities and differences in power chord usage throughout them. There are also definite links between Western art music and death metal, most notably in harmonic function, form and manipulation of texture for a desired effect. Distinct emphasis on virtuosity and soloistic playing is also characteristic of death metal, which is where it diverts from similarities to Rock and other pop genres, despite their shared superficial harmonic simplicity. This project provides insight into how power chords in context are used to create the quintessential ‘metal’ sound and how the genre thrives off of subtle alterations to the listener’s expectations of traditional tonal harmony. Harmonic analyses focussing on the use of power chords and resultant textural changes show that consistent compositional idioms of metal can be isolated across Scandinavian subgenres and will ultimately provide a basis for further analytical research.
Female rhetoric: Identity, persona and the academic and popular divide in the (cultural and critical) study of metal
Authors: Porrovecchio Mark J. 
Published: June 2017

Abstract
There has been a substantial amount of productive scholarship, particularly in the areas of critical and cultural studies, regarding the depictions of women in metal music. At the same time, there remains a divide between this important academic work and those who are popular consumers of metal. This short essay offers a potential middle path between the two. Through the use of interviews with three women involved in creating content related to metal, the author offers a two-part suggestion: (1) that the divide itself might be a matter less of content than of translation and (2) that rhetoric, of the sort practiced in departments of speech communication, could potentially provide another useful option when presenting scholarship to popular audiences.
Book Reviews
Authors: Hagen Ross , Kopanski Reinhard , Kahn-Harris Keith , Zevolli Giuseppe 
Published: June 2017

Abstract

The Death Archives: Mayhem 1984–94, Jørn Stubberud (2016)
London: Ecstatic Peace Library, 256 pp.,
ISBN: 9780997285031, h/bk, £30

Zwischen Germanomanie und Antisemitismus. Transformationen Altnordischer Mythologie In Den Metal-Subkulturen, (‘Between Germanomania and Anti-Semitism: Transformations of Norse Mythology in the Metal Subcultures’), Niels Penke and Matthias Teichert (eds) (2016)
Baden: Nomos Verlagsgesellschaft, 216 pp. ISBN: 9783848712755, p/bk, 39.00€

Sounds of the Underground: A Cultural, Political and Aesthetic Mapping of Underground and Fringe Music, Stephen Graham (2016)
Michigan: University of Michigan Press, 304 pp.,
ISBN: 978-0-472-11975-2, h/bk, $70

England’s Hidden Reverse: A Secret History of the Esoteric Underground, David Keenan (2016)
London: Strange Attractor Press, 446 pp. ISBN: 978-1-907222-17-7, p/bk, £20
Análise dos Motivos dos Jovens e Adultos consumirem Álcool
Authors: Soares Fernanda de Jesus , Oliveira Daiana Cirqueira , Oliveira Paula Rocha , Lima Tatiane Souza , Alves Adriana Lopes Rodrigues , Silva Matheus Lemos , Duarte Stênio Fernando Pimentel 
Published: June 2017

O álcool é uma droga lícita responsável por deprimir o Sistema Nervoso Central e é tida como uma das substâncias com maior grau de consumo a nível mundial, a Organização Mundial da Saúde (WHO) traz que em média dois bilhões de pessoas fazem o consumo de bebidas alcoólicas, compreendendo tanto o uso por dependentes quanto o uso social. A indústria do marketing do álcool nos dias atuais age globalmente, tanto em países industrializados quando nos que ainda estão em desenvolvimento. Entretanto existem fatores além do marketing e o fácil acesso ao álcool, que podem levar ao seu consumo, como o incentivo através de amizades, isso se deve principalmente a necessidade de se enquadrar em grupos na sociedade. Esse artigo traz como objetivo a análise desses motivos pelos quais os jovens e adultos consomem o álcool. Metodologia: O presente estudo faz parte do projeto “Identificando o perfil epidemiológico da Obesidade em Vitória da Conquista” idealizado pelo Núcleo de Extensão, Pesquisa e Estudo de Doenças Crônicas – NEPEDC da Faculdade Independente do Nordeste. O procedimento portou-se inicialmente através da aplicação de questionário, instrumento para coleta de dados que continha perguntas pertinente ao estudo, seguido de uma segunda entrevista realizada via ligação telefônica. Esses procedimentos foram realizados com indivíduos aleatórios, com faixa etária entre 20 a 59 anos, considerados jovens adultos. Resultados: A prevalência entre jovens e adultos é de 16% Jovens adultos, 59% Adultos e 21% Adultos velhos. A idade de inicio do consumo de álcool, 61% relataram que foi ainda na adolescência e 39% já na fase adulta. Em relação aos motivos que levam os jovens e adultos consumirem álcool 57% disseram ser para interagir com colegas, 16% para distrair-se de alguma situação/ problema, 14% para aliviar tensão/stress, 7% disseram beber por lazer, 4% em expectativa em algo positivo e 2% para aumento de confiança em situações com outras pessoas. Em relação aos meios que induziram os pesquisados a consumirem bebidas alcoólicas pela primeira vez, 68% disseram ter experimentado através de amigos, 23% por interesse próprio/curiosidade e 9% por meio de parentes. Nos resultados, dos lugares em que os pesquisados consomem álcool com mais frequência, 34% disseram ser em casa, 31% em bares, 29% em casas de amigos e 6% em clubes. Conclusão: Esta pesquisa foi voltada para análise dos motivos que levam os jovens e adultos a consumirem álcool, e em concordância com a avaliação dos dados e as informações literárias, é possível concluir que este consumo possa ser influenciado por diversos fatores. Notasse que a sociedade impõe de certo modo, normas e valores que seriam essenciais para uma harmonia social e hoje o uso de bebidas alcoólicas na sociedade está diretamente ligado a própria vivência que assegura uma vida social.
Eskisehir cuisine in the menus of food and beverage businesses in Eskisehir<p>Eskişehir’deki yiyecek içecek işletmelerinin menülerinde Eskişehir mutfağının yeri
Authors: Dündar Arıkan Alev 
Published: June 2017

Regional cuisine and hence regional food has an important role in terms of both their intangible cultural heritage property and being among the destinations attractive elements. Preserving regional food and transferring them to future generations can be provided through promoting recognition and use. This study includes a qualitative research wich on the menus of hotel restaurants and independent food and beverage businesses in order to determine the extent of Eskisehir cuisine provided, analyzing the local food defined through literature review. The research is based on content analysis of menus of 53 food and beverage companies, conducted in April, 2016. The results of this study not only show the current situation about the local dishes which is an important tourist attraction how used in Eskişehir but also guide the determination of the local foods that can be offered in the enterprises operating in Eskişehir. The results indicate that Eskisehir cuisine is not provided enough both by hotel restaurants and independent food and beverage businesses, and majority of the businesses do not offer local foods in their menus. Extended English abstract is in the end of PDF (TURKISH) file. ÖzetYöresel mutfak ve dolayısıyla yöresel yemekler gerek somut olmayan kültürel miras özelliği taşıması gerekse destinasyonların çekicilik unsurları arasında yer alması açısından önem taşımaktadır. Yöresel yemeklerin turistik çekicilik amaçlı kullanılabilmesi yanında yaşatılması ve gelecek nesillere aktarılabilmesi de onların tanınırlığının ve kullanımının yaygınlaştırılması ile sağlanabilir. Bu çalışma, alanyazın taramasına dayalı olarak belirlenen Eskişehir mutfağına ait yöresel yemeklerin, Eskişehir’de gerek otel işletmelerine bağlı gerekse bağımsız olarak faaliyet gösteren yiyecek içecek işletmelerinin menülerinde ne derece sunulduğunu belirlemek amacıyla gerçekleştirilen nitel bir araştırmayı içermektedir. Araştırma, 2016 yılı nisan ayı içerisinde 53 adet yiyecek içecek işletmenin menüleri üzerinden gerçekleştirilen içerik analizine dayalıdır. Bu çalışma ile edilen sonuçlar, önemli bir turistik çekicilik unsuru olan yöresel yemeklerin Eskişehir’de ne derece kullanılmakta olduğuna dair mevcut durumu ortaya koymanın yanında, Eskişehir’de faaliyet gösteren yeme-içme işletmelerinde sunulabilecek yöresel yemeklerin belirlenmesinde de yol gösterici niteliktedir. Çalışmanın sonuçları genel olarak Eskişehir’de faaliyet gösteren gerek bağımsız gerekse otel işletmelerine bağlı restoranların menülerinde yöresel yemeklere yeterince yer verilmediğini ortaya koymaktadır.