bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the Role of miR-29a in the Regulation of RAG1, a Gene Associated with the Development of the Immune System
Authors: Roy Urbi , Desai Sagar Sanjiv , Kumari Susmita , Bushra Tanzeem , Choudhary Bibha , Raghavan Sathees C 
Published: September 2024

Abstract
The process of Ag receptor diversity is initiated by RAGs consisting of RAG1 and RAG2 in developing lymphocytes. Besides its role as a sequence-specific nuclease during V(D)J recombination, RAGs can also act as a structure-specific nuclease leading to genome instability. Thus, regulation of RAG expression is essential to maintaining genome stability. Previously, the role of miR29c in the regulation of RAG1 was identified. In this article, we report the regulation of RAG1 by miR-29a in the lymphocytes of both mice (Mus musculus) and humans (Homo sapiens). The level of RAG1 could be modulated by overexpression of miR-29a and inhibition using anti-miRs. Argonaute2-immunoprecipitation and high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation studies established the association of miR-29a and RAG1 with Argonaute proteins. We observed a negative correlation between miR-29a and RAG1 levels in mouse B and T cells and leukemia patients. Overexpression of pre–miR-29a in the bone marrow cells of mice led to the generation of mature miR-29a transcripts and reduced RAG1 expression, which led to a significant reduction in V(D)J recombination in pro-B cells. Importantly, our studies are consistent with the phenotype reported in miR-29a knockout mice, which showed impaired immunity and survival defects. Finally, we show that although both miR-29c and miR-29a can regulate RAG1 at mRNA and protein levels, miR-29a substantially impacts immunity and survival. Our results reveal that the repression of RAG1 activity by miR-29a in B cells of mice and humans is essential to maintain Ig diversity and prevent hematological malignancies resulting from aberrant RAG1 expression in lymphocytes.
Investigating the influencing factors of evidence-based healthcare practice adoption
Authors: Motsi Lovemore 
Published: September 2024

Background: In healthcare facilities, evidence-based healthcare practice (EBHP) is becoming more widely acknowledged as a critical element of patient care delivery. An increasingly important component of EBHP is the implementation of electronic health records (EHRs).Objectives: This study aims to investigate factors that influence EBHP adoption in public healthcare institutions in South Africa.Method: Four hundred and fifty patients were self-administered to healthcare professionals at an academic public hospital in Gauteng and used in this study. A total of 300 responses were available for use in the final analysis following the data cleaning procedure. Utilising structural equation modelling (SEM), the collected data were analysed.Results: Perceived ease of use (PEOU) and perceived usefulness (PU) were found to be major variables in the adoption of EBHP along with technological, organisational and environmental factors. The technology context relative advantage (RELA) was shown to have a positive significant influence on the adoption of evidence-based healthcare practice by the PEOU and PU, with the environmental context government laws and regulations (GLRS) and organisational context organisational readiness (ORGR) coming in second and third, respectively.Conclusion: Perceived ease of use, PU, ORGR, and GLRS are regarded as a vital variables in the implementation of EBHP in South African public hospitals.Contribution: The study’s conclusions would be helpful to policymakers as they redefine nursing practice. Furthermore, the findings heighten the consciousness of healthcare practitioners regarding the significance of employing evidence-based practice while making decisions.
Artificial intelligence’s challenges to the essence of humanity from the perspective of Martin Luther’s anthropology in Chinese context
Authors: Huang Paulos Z.Z. 
Published: September 2024

This article argued the following points. Firstly, the challenge posed by artificial intelligence (AI) to the essence of humanity is serious. Secondly, it is important to analyse the external context and internal dynamics of the history of interaction between knowledge and power. Thirdly, it is necessary to trace the intellectual history of humanity becoming god-like. Finally, by combining Martin Luther’s anthropology with insights from social science and philosophical theology, this article advocated for guiding human beings to use their capabilities for good rather than evil through ethical and legal constraints. Efforts in Chinese context should be made to resolve the conflict between humanity’s pursuit of omnipotence and its failure to develop towards complete goodness, so as to avoid catastrophic consequences for humanity.Contribution: The present article’s special contribution was the theological reflection referring to AI’s challenges to the essence of humanity from Luther’s anthropology in Chinese context. The conflict between omnipotence and omnibenevolence has been highlighted as the key problem which human beings need to solve in the face of AI’s challenge.
Exploring Joshua 7:1–5 through the lens of social contagion liability
Authors: Odo Damian O. , Human Dirk J. 
Published: September 2024

Scholars of the Old Testament affirm that the book of Joshua through 2nd Kings is collectively called the deuteronomistic history. The literary unit of Joshua 7:1–5 is one the Locus Classicus of Old Testament. Obedience to God’s instruction underscores the theological intentionality expressed in this unified segment of Old Testament literature. This ancient Israelite literary exposition exposes inter-alia the misfortune that besets the entire people of Israel as a result of Achan’s moral transgression. The consequence of Achan’s antisocial behaviour was so contagious that it spread across to the entire populace of Israel as they were humiliated and defeated in a battle by the warriors of Ai. This pericope has been studied in various perspectives by commentators and scholars of the Old Testament; however, a survey of available literature shows that it has not been explored by scholars from the orbit of social contagion liability. Therefore, this article intends to engage the literary unit, employing the lens of social contagion liabilityIntradisciplinary and/or interdisciplinary implications: This study engaged the literary unit of Joshua 7:1–5 from the orbit of social contagion liability. It argues that Achan’s anti-social behaviour spread to the entire populace of Israel and got them contaminated and exposed to misfortune because it has the characteristics of social contagion liability. The study contributed to Old Testament Exegesis, sociology and social contagion study.
Autoría compleja: museo, archivos, laboratorio
Authors: Mendoza Juan J. 
Published: September 2024

Entre los años 2006 y 2010, Reinaldo Laddaga publicó Estética de la emergencia y Estética de laboratorio, dos libros especialmente abocados a una reflexión profunda sobre los modos de comprender la teoría y la crítica literaria aplicadas no solo a los textos literarios sino también a las obras de arte, el cine y otros dispositivos culturales. Sensible a una nueva “cultura de las artes”, el concepto de Laddaga de “autoría compleja” de inmediato se reveló como una noción particularmente productiva para comprender una serie de obras artísticas del siglo XXI. De hecho, el propio Laddaga ensayó formas de arte y de “literatura compleja”, en coautoría -siguiendo sus propias formulaciones- con Borges, Bioy Casares, Jean de Mandeville, Thomas de Quincey, Raymond Russel o Herman Melville. A casi veinte años del primero de esos libros y a más de una década del segundo, el presente trabajo rescata la productividad de las elaboraciones teóricas de Laddaga a la luz no solo de su propia producción literaria, sino también en diálogo con otras obras particularmente sensibles a las ideas de este autor.
Effectiveness of Risk Management through Risk Maturity Measurement: A Study at PT Pelabuhan Indonesia
Authors: Utami Lestari , Djunita Pasaribu Rina 
Published: September 2024

Research aims: This study aims to evaluate the effectiveness of risk management at Pelindo post-merger and measure its risk management maturity level. Moreover, the study intends to offer relevant recommendations for the company in developing risk management strategies and implementation. Design/Methodology/Approach: This study adopts a qualitative descriptive approach with a case study strategy, wherein the researcher analyzes an organization as the unit of analysis in a non-contrived setting, reflecting a natural environment without manipulation. Data collection techniques include interviews and document analysis, while data analysis follows the Miles and Huberman model with four main components: data collection, data reduction, data presentation, and conclusion drawing. Research findings: The study's findings indicate that the risk management maturity level at Pelindo post-merger is at the good practice phase, scoring 2.94 from the dimension and performance aspects assessment. Recommendations for improvement include enhancing risk culture, improving the effectiveness of risk management functions, and aligning risk strategy with the ERM transformation plan to increase the effectiveness and compliance of risk management. Theoretical Contribution/Originality: This research makes a theoretical contribution by assessing the level of risk management maturity in the context of mergers among state-owned enterprises (SOEs) in Indonesia's maritime industry. It uses measurement methods tailored to regulations from the Ministry of SOEs, providing a reference for other companies seeking to develop effective risk management strategies. Practitioners/Policy Implications: This research suggests that organizations should strengthen risk culture responsibilities in job descriptions at all levels, as well as adopt technology and automation for real-time risk monitoring to enhance risk management effectiveness and ensure alignment with corporate strategy. Research Limitations/Implications: The limitations of this study primarily stem from restricted access to internal and sensitive data, which constrains the depth of analysis and hampers comparison with industry best practices.
Enhancing Employee Performance through Monetary Incentives
Authors: Abraveni Varalakshmi  
Published: September 2024

Monetary incentives lead a parent role of an employee to focus on their future step, understand their responsibility in the organization, and understand their benefit also this system changes staff work morale so generally thorough the way of financial reward enhancing employee performance .Monetary incentives play a important role in every employee working under any organization because he is getting an extra financial support from the organization were it will lead to work hard for the organization salaries and bonuses are part of the monetary incentives which motivate the employees in addition to some non -monetary incentives such as free food, commute taken care of, and paid vacations with family as well as healthcare options etc. Indeed, in the United States, and in some Western countries where healthcare is not provided by the government, many workers and employees in businesses often join to the inducement of employer provided health insurance packages In addition, the more senior you are in the organizational hierarchy, the better are your chances to avail of incentives such as ESOPs or Employee Stock Option Plans, paid vacations, chauffeur driven cars, as well as plush accommodation that is paid for by their employers. Apart from this, in many corporates, midlevel and junior level employees to receive some of these benefits based on their performance. In other words, these incentives are often used to enhance employee performance in organizations. Along with this, the organization also gets the benefit of suggestions in new thinking. It is true that efforts should be made to make the employees mentally strong for the development of the organization, but they should also get their remuneration in the form of money. The main objective is to analyze the effect of monetary and nonmonetary rewards toward employees’ performance.
Analisis Prosedur Pembelian dan Negosiasi Bisnis pada PT. Daya Satya Abrasives
Authors: Daka Radhiyan Yahya  , Sumainah Fauziah  
Published: September 2024

Purchasing is the process of finding sources to provide the goods and services a company needs to support its business activities. The purchasing department acts as an intermediary between the purchasing company and the suppliers. Standard Operating Procedure (SOP) is a written document that contains detailed instructions or guidelines on how a task or process must be carried out consistently and efficiently. business negotiation is reaching an agreement that meets the interests and needs of all parties involved. This study uses a qualitative research method, where appropriate data collection is carried out regarding the purchasing procedures and business negotiations that apply at PT. Daya Satya Abrasives. The quality objectives required by the purchasing department include timeliness of arrival, variance, inventory stock. The conclusion that can be drawn is that in the purchasing process there are obstacles faced by the purchasing or purchasing department, such as late delivery schedules from business partners because that is very influential for the company. And there is also a problem with terms of payment where partners refuse to pay credit (7days, 14days, 30days). In dealing with this problem, the purchasing party always follows up or monitors the requested goods so that there are no delays and as much as possible convinces the supplier to get better terms of payment.

Keywords: negotiation business, Purchasing, purchasing procedure
Pandangan Gen Z Terhadap Live Music Yang Menambah Minat Konsumen Coffee Shop Di Kota Solo
Authors: Muhammad Annang Fahmi Roziq  , Syahri Romadhon  , Rayhan Gunaningrat  
Published: September 2024

This study aims to determine Generation Z's views on live music that increases consumer interest in coffee shops in Solo. This research uses the Grounded Theory method, which is qualitative research that aims to develop theory from empirical data directly without any prior theory or hypothesis. Semi-structured interviews were conducted with several Gen Z in one of Solo's coffee shops. The results of the interviews with Gen Z show the complexity of views on live music in coffee shops. The existence of live music can increase the attractiveness of coffee shops. Experience, identity, sensation seeking and peer influence play an important role in attracting coffee shop consumers.
Hubungan Pengetahuan Tentang Personal Hygiene Dengan Penyembuhan Robekan Perineum Di Klinik Romana Tanjung Anom
Authors: Alisarjuni Padang  
Published: September 2024

Postpartum infections, such as sepsis, are still the main cause of maternal death in developing countries. This study aims to determine the relationship between knowledge about personal hygiene and perineal wound healing in post-partum mothers at the Romana Tanjung Anom Clinic, Sidodadi Village in 2023. The research method used is an analytical survey with a cross-sectional approach. The population was all 32 post partum mothers with birth canal lacerations, and all of them were used as research samples. The results of the research show that there is a relationship between knowledge about personal hygiene and healing of perineal wounds in post-partum mothers, seen from the results of the chi-square test, which showed a p value of 0.003 < 0.005. It is hoped that health workers at the Romana Tanjung Anom Clinic will provide counseling to post partum mothers about personal hygiene so that mothers get information about how to carry out personal hygiene correctly so that perineal wounds can heal in <6 days
ĐÁNH GIÁ CHỈ SỐ VIÊM MIỄN DỊCH HỆ THỐNG TRÊN BỆNH NHÂN VẢY NẾN
Authors: Ngô Thị Phương Uyên , Văn Thế Trung 
Published: September 2024

Mục tiêu nghiên cứu: Đánh giá chỉ số viêm miễn dịch hệ thống (SII) trên bệnh nhân vảy nến. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, bao gồm 80 bệnh nhân được chẩn đoán vảy nến từ đủ 18 tuổi trở lên điều trị tại Bệnh viện Da liễu Thành phố Hồ Chí Minh từ tháng 12/2022 đến tháng 10/2023 và 40 người khoẻ mạnh đối chứng. Kết quả: Giá trị chỉ số SII không có sự khác biệt mang ý nghĩa thống kê giữa nhóm bệnh nhân có tiền căn gia đình và nhóm bệnh nhân không có tiền căn gia đình (p = 0,9), giữa nhóm bệnh nhân có tổn thương móng và nhóm bệnh nhân không có tổn thương móng (p = 0,2). Không tìm thấy mối tương quan giữa giá trị chỉ số SII với tuổi bệnh nhân (r = 0,008; p = 0,94), tuổi khởi phát (r = 0,006; p = 0,94), thời gian mắc bệnh (r = 0,01; p = 0,94). Giá trị chỉ số SII ở bệnh nhân vảy nến và chỉ số PASI có tương quan thuận mức độ trung bình (r = 0,4834; p < 0,001). Giá trị chỉ số SII tương quan thuận mức độ yếu với nồng độ hs-CRP (r = 0,2507; p < 0,05) và tốc độ lắng máu (r = 0,2411; p = 0,03). Giá trị chỉ số SII có mối tương quan thuận mức độ mạnh với cả hai chỉ số NLR, PLR với hệ số tương quan lần lượt là 0,908; 0,7691 (p < 0,0001). Kết luận: Chỉ số viêm miễn dịch toàn thân được phát hiện ở những bệnh nhân mắc bệnh vẩy nến cao hơn đáng kể so với những người khỏe mạnh. Chỉ số viêm miễn dịch toàn thân có thể đóng vai trò là phương pháp hỗ trợ trong chẩn đoán lâm sàng bệnh vảy nến.
BIỂU HIỆN CỦA DẤU ẤN TẾ BÀO GỐC UNG THƯ (EPCAM) TRONG UNG THƯ BIỂU MÔ TUYẾN ĐẠI TRỰC TRÀNG
Authors: Tiền Thanh Liêm 
Published: September 2024

Đặt vấn đề: Phân tử kết dính tế bào biểu mô (Epithelial Cell Adhesive Molecule - EPCAM) là một glycoprotein có liên quan đến sự phát triển và di căn của ung thư biểu mô tuyến đại tràng. Mục tiêu nghiên cứu: khảo sát kiểu biểu hiện của EPCAM trong ung thư biểu mô tuyến đại trực tràng và mối liên quan của chúng với đặc điểm giải phẫu bệnh, đặc biệt là giai đoạn pTNM. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang của 102 bệnh nhân được chẩn đoán ung thư biểu mô tuyến đại tràng, tại Bệnh viện 30-4. Dùng phương pháp nhuộm hóa mô miễn dịch với dấu ấn EPCAM trên các khối block parafin. Kết quả: Không có trường hợp nào biểu hiện âm tính. Biểu hiện dương tính theo phương pháp đánh giá của Mokhtari như sau: 52,9% dương tính mạnh, 25,5% dương tính trung bình đến mạnh, 9,8% dương tính trung bình, 11,8% dương tính yếu; theo phương pháp đánh giá của Spizzo như sau: 34,3% dương tính mạnh, 36,3% dương tính trung bình, 29,4% dương tính yếu. Sự khác biệt kiểu biểu hiện của EPCAM với các lứa tuổi trung bình có ý nghĩa thống kê, p<0,05 và mối liên quan nghịch giữa kiểu biểu hiện EPCAM và lứa tuổi trung bình có ý nghĩa thống kê, p<0,001. Kết luận: Kiểu biểu hiện của EPCAM khác nhau giữa các lứa tuổi và biểu hiện EPCAM dương tính thấp khi tuổi càng cao.
Ozone anomalies over the polar regions during stratospheric warming events
Authors: Shi Guochun , Krochin Witali , Sauvageat Eric , Stober Gunter 
Published: September 2024

Abstract. The impact of major sudden stratospheric warming (SSW) events and early final stratospheric warming (FSW) events on ozone variations in the middle atmosphere in the Arctic is investigated by performing microwave radiometer measurements above Ny-Ålesund, Svalbard (79° N, 12° E), with GROMOS-C (GRound-based Ozone MOnitoring System for Campaigns). The retrieved daily ozone profiles during SSW and FSW events in the stratosphere and lower mesosphere at 20–70 km from microwave observations are cross-compared to MERRA-2 (Modern-Era Retrospective Analysis for Research and Applications, version 2) and MLS (Microwave Limb Sounder). The vertically resolved structures of polar ozone anomalies relative to the climatologies derived from GROMOS-C, MERRA-2, and MLS shed light on the consistent pattern in the evolution of ozone anomalies during both types of events. For SSW events, ozone anomalies are positive at all altitudes within 30 d after onset, followed by negative anomalies descending in the middle stratosphere. However, positive anomalies in the middle and lower stratosphere and negative anomalies in the upper stratosphere at onset are followed by negative anomalies in the middle stratosphere and positive anomalies in the upper stratosphere during FSW events. Here, we compare results by leveraging the ozone continuity equation with meteorological fields from MERRA-2 and directly using MERRA-2 ozone tendency products to quantify the impact of dynamical and chemical processes on ozone anomalies during SSW and FSW events. We document the underlying dynamical and chemical mechanisms that are responsible for the observed ozone anomalies in the entire life cycle of SSW and FSW events. Polar ozone anomalies in the lower and middle stratosphere undergo a rapid and long-lasting increase of more than 1 ppmv close to SSW onset, which is attributed to the dynamical processes of the horizontal eddy effect and vertical advection. The pattern of ozone anomalies for FSW events is associated with the combined effects of dynamical and chemical terms, which reflect the photochemical processes counteracted partially by positive horizontal eddy transport, in particular in the middle stratosphere. In addition, we find that the variability in polar total column ozone (TCO) is associated with horizontal eddy transport and vertical advection of ozone in the lower stratosphere. This study enhances our understanding of the mechanisms that control changes in polar ozone during the life cycle of SSW and FSW events, providing a new aspect of quantitative analysis of dynamical and chemical fields.
TEXT Poetry, Prose & Script Oct 2020
Authors: Allen Richard James , Brooks Ned , Carbis Gayelene , Caruso Edward , Cherriman Becky , East Tara , Edmonds Phillip , Fisher Abigail , Gerrish Carolyn , Licari Rosanna , Kerrison Dean , McBride Cailean , Phillips Georgia Rose , Prendergasat Julia , Rae Lauren , Rhodes Lachie , Riveros Ariel , Simpkins Laura Grace , Stubbings Diane , West Patrick 
Published: September 2024

New creative works exploring creativity, the nature and processes of writing or teaching writing. Poetry Richard James Allen, Click here to allow this poem to access your location Gayelene Carbis, Oranges Edward Caruso, Potsherds Becky Cherriman, Christina Tissues a Script (or what my Otter app misheard) Abigail Fisher, A un poema acerca del agua Carolyn Gerrish, Aperture Lauren Rae, Hemispheric March Script Cailean McBride, Be Near Me (after In Memoriam) Prose Julia Prendergast, Mothwebs, spinners, orange Patrick West, Pauline Laura Grace Simpkins, Vanilla Phillip Edmonds, Giving it away Rosanna Licari, Fiona and the fish Georgia Rose Phillips, On the Obfuscations of Language Diane Stubbings, From Variation for three voices on a letter to nature Ariel Riveros, Planetary Nephology Calendar App Dean Kerrison, 2 stories Lachie Rhodes, The Silver Locket Tara East, Story Monster Ned Brooks, This is Not a Film
TEXT Poetry and Prose Oct 2019
Authors: Fisher Jeremy , Nash Peter , Melick Tom , Maller Gershon , Nash Peter , Ross Conor , Smith Ian , Vulcan Julie , Wakelin Oliver 
Published: September 2024

Jeremy Fisher, When ‘I’ is me: an author in search of his character Ian Smith, 2 prose poems Tom Melick, Notes from a Residency Gershon Maller, 2 sonnets about poetry Oliver Wakelin, North Julie Vulcan, Dark Arts: Keeping Company with Witch’s Eggs and Devil’s Fingers Peter Nash, And the process perplexed them Conor Ross, The Imp in Imperfection
TEXT Prose April 2021
Authors: Downing Jane , Green Stephanie , Kerrison Dean , Lazaroff Tamara , Jain Jinendra , Kadmos Helena , Philllips Georgia Rose , Prendergast Julia , Raynes Cameron 
Published: September 2024

New stories exploring creativity, or the nature and processes of writing or teaching writing. Jane Downing, The Raven and the Writing Desk Stephanie Green, An Unforgettable Dining Experience Jinendra Jain, See Like a Child; Think Like an Adult: Creating Space between Perception and Thought Helena Kadmos, Pockets Dean Kerrison, Occupied Tamara Lazaroff, Not A Story But An Exchange Georgia Rose Phillips, The RRP of Narrative Julia Prendergast, 2 stories Cameron Raynes, Dog Rock