bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statin therapy prevents the onset of Parkinson disease in patients with diabetes
Authors: Lin Kun‐Der , Yang Chun‐Yuh , Lee Mei‐Yueh , Ho Shu‐Chen , Liu Ching‐Kuan , Shin Shyi‐Jang 
Published: August 2016

ObjectiveWe studied the association between the statin dosage and the risk of Parkinson disease (PD) in diabetic patients in Taiwan.MethodsOne million patients were randomly sampled from a National Health Insurance (NHI) database and followed from 2001 to 2008. Diabetic patients were screened by diagnosis of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) codes, and statin dosage was determined according to the NHI pharmacy database. PD was diagnosed on the basis of ICD‐9‐CM codes and anti‐Parkinson medication use. Statin users was classified by statin dose‐duration‐day > 28 and matched with nonusers of statins using a coarsened exact matching method. There were 50,432 patients, and half of them were statin users. We examined the risk of PD between statin users and nonusers of statins and further tested the trends of the relative risk between the statin dosage and PD.ResultsThe PD incidence rate was lower in statin users than in nonusers of statins. The crude hazard ratio of PD incidence in statin users was 0.65 (95% confidence interval [CI] = 0.57–0.74) in females and 0.60 (95% CI = 0.51–0.69) in males compared with nonusers of statins. After Cox regression analysis, all statins except lovastatin exerted protective effects on PD incidence and had a significant dose‐dependent trend.InterpretationIn Taiwanese diabetic patients, the risk of PD is lower in statin users than in nonusers of statins. Statin users, except lovastatin users, are dose‐dependently associated with a decreased incidence of PD compared with nonusers of statins. This finding provides a new indication for statin beyond lipid control and cardiovascular events in diabetic patients. Ann Neurol 2016;80:532–540
Waterborne polyurethane nanocomposites based on vegetable oil and microfibrillated cellulose
Authors: Hormaiztegui María Eugenia Victoria , Mucci Verónica Luján , Santamaria‐Echart Arantzazu , Corcuera María Ángeles , Eceiza Arantxa , Aranguren Mirta Inés 
Published: August 2016

ABSTRACTThis work analyzes the differences in the final properties of two waterborne polyurethanes (WBPU) prepared with two macrodiols of different chemical structure, but similar molecular weight, as well as the variations caused by incorporating low percentages of microfibrillated cellulose nanocrystals. One of the polyurethanes was based on a synthetic but biodegradable precursor (polycaprolactone diol, PCL) and a second one based on a bio‐based macrodiol derived from castor oil (CO1). The bio‐based material presented higher mechanical properties at room temperature than the synthetic one, with the Young's modulus (MPa) ranging from 2.23 ± 0.09 to 84.88 ± 0.96 for the PCL and bio‐based WBPUs, respectively. Additionally, the PCL‐based WBPU showed to be more sensitive to the incorporation of cellulose than the bio‐based WBPU, and it also suffered changes during time due to delayed crystallization. The behavior of the two systems were compared and related to the different structure of the macrodiols that led to different interfacial interactions. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44207.
Five‐year mortality outcomes in patients with chronic kidney disease undergoing percutaneous coronary intervention
Authors: Patel Agam D. , Ibrahim Mohammed , Swaminathan Rajesh V. , Minhas Irfan U. , Kim Luke K. , Venkatesh Prashanth , Feldman Dmitriy N. , Minutello Robert M. , Bergman Geoffrey W. , Wong S. Chiu , Singh Harsimran S. 
Published: August 2016

ObjectiveTo examine peri‐procedural and long‐term outcomes in patients with chronic kidney disease (CKD) undergoing percutaneous coronary interventions (PCI).BackgroundPatients with advanced CKD are considered high risk when undergoing PCI. Limited published data exist on quantifying risk and assessment of long‐term outcomes after PCI in this group.MethodsExamining the Cornell Coronary Registry, we prospectively collected data of 6,478 consecutive patients who underwent elective or urgent PCI between 2009 and 2013. Patients were grouped into CKD stages by estimated glomerular filtration rate (eGFR) according to KDOQI guidelines. Procedural and 30‐day outcomes are reported with assessment of long‐term differences in 5‐year all‐cause mortality.ResultsPatients were grouped by CKD stages: 1,351 patients with eGFR ≥90 mL/min/1.73 m2 (stage 1), 2,882 with eGFR 60–89 (stage 2), 1,742 with eGFR 30–59 (stage 3), 191 with eGFR 15–29 (stage 4), and 312 with eGFR <15 or on dialysis (stage 5). The incidence of post‐procedural acute heart failure, stroke, new dialysis requirement, transfusions, and bleeding events were higher in patients with greater CKD stage (P < 0.05). Five‐year Kaplan–Meier overall survival among CKD stages 1–5 was 98.1, 95.5, 91.8, 82.5, and 76.9%, respectively (P < 0.001 by log‐rank test). The hazard ratios of all‐cause mortality for CKD stages 2–5 as compared to stage 1 by multivariate Cox regression analysis were as follows: 1.32 (P = 0.26), 2.04 (P < 0.01), 2.79 (P < 0.01), and 5.49 (P < 0.001).ConclusionAmong patients undergoing PCI, lower GFR is associated with decreased long‐term survival. © 2016 Wiley Periodicals, Inc.
Analysis, design and simulation of Internet of Things routing algorithm based on ant colony optimization
Authors: Said Omar 
Published: August 2016

SummaryIn this paper, a routing algorithm to optimize the selection of the best path for the transmitted data within the Internet of Things (IoT) system is proposed. The algorithm controls the use of ant colony ideas in the IoT system to obtain the best routing benefit. It divides the IoT environment into categorized areas depending on network types. Then, it applies the most suitable ant colony algorithm to the concerned network within each area. Furthermore, the algorithm considers routing problem in intersected areas that may arise in case of IoT system. Finally, Network Simulator 2 is used to evaluate the proposed algorithm performance. Simulation results demonstrate the effectiveness of the proposed routing algorithm in terms of end‐to‐end delay, packet loss ratio, bandwidth consumption, throughput, overhead of control bits, and energy consumption ratio. Copyright © 2016 John Wiley & Sons, Ltd.
Combination of Vildagliptin and Pioglitazone in Experimental Type 2 Diabetes in Male Rats
Authors: Refaat Rowaida , Sakr Ahmed , Salama Mona , El Sarha Ashgan 
Published: August 2016

ABSTRACT

Preclinical Research

The majority of studies on vildagliptin and pioglitazone have focused on their combination in glycemic control. The aim of the present study was to investigate their effects in combination on (i) hyperglycemia‐induced oxidative stress and inflammation and (ii) on organs involved in the pathophysiology of diabetes, pancreas, kidney and liver. Type 2 diabetes was induced using low‐dose streptozotocin in male Wistar rats. Diabetic rats were treated for 4 weeks, with vildagliptin (10 mg/kg/day), pioglitazone (10 mg/kg/day) and their combination. Diabetic rats showed elevated fasting serum glucose, fasting serum insulin, serum transaminases together with a deleterious lipid profile and elevated serum creatinine and urea concentrations. Serum levels of the inflammatory markers tumor necrosis factor‐α (TNF‐α) and nitrite/nitrate were also elevated compared to normal rats. Oxidative stress was manifested by lowered hepatic reduced glutathione (GSH) and increased malondialdehyde (MDA) levels. Pancreatic sections from diabetic rats showed degenerated islets with poorly maintained architecture that was prevented by drug treatment. Pioglitazone was generally more effective than vildagliptin in the studied parameters except for the lipid profile where the effect of both drugs was comparable and for the liver enzymes and renal parameters where vildagliptin was more effective. The combination of vildagliptin and pioglitazone produced superior effects than either drug alone. Drug Dev Res 77 : 251–257, 2016. © 2016 Wiley Periodicals, Inc.
Synthesis and Biological Evaluation of Novel Carbohydrate‐Derived Derivatives of Erlotinib
Authors: Yu Wenbo , Jiang Luxia , Shen Chao , Zhang Pengfei 
Published: August 2016

Abstract

Preclinical Research

A series of novel carbohydrate‐derived Erlotinib derivatives were prepared by the copper‐catalyzed cycloaddition reaction of erlotinib with various azido‐sugars. The structures of the newly synthesized compounds were characterized and their cytostatic effects evaluated in vitro on human cancer cell lines MDA‐MB‐231, HEPG‐2, A549, and MCF‐7 using an MTS assay. The novel erlotinib derivatives had the expected inhibitory effects on MDA‐MB‐231 and HEPG‐2 cell llines. Among the compounds evaluated the carbohydrate‐derived compounds 5b, 5d, 6a, and 6c had more potent activities against MDA‐MB‐231 or HEPG‐2 than Erlotinib. Drug Dev Res, 2016. © 2016 Wiley Periodicals, Inc.
Broad‐complex, tramtrack, and bric‐à‐brac (BTB) proteins: Critical regulators of development
Authors: Chaharbakhshi Edwin , Jemc Jennifer C. 
Published: August 2016

AbstractBroad‐complex, Tramtrack, and Bric‐à‐brac/poxvirus and zinc finger (BTB/POZ) family proteins are a diverse family of proteins that are characterized by the presence of a common protein‐protein interaction domain, known as the BTB domain. BTB proteins have been identified in poxviruses and many eukaryotes, and have diverse functions, ranging from transcriptional regulation and chromatin remodeling to protein degradation and cytoskeletal regulation. Specificity of function is determined in part by additional domains present in BTB family proteins, as well as by interaction partners. Studies of BTB proteins in Drosophila and mammalian systems have revealed the importance of these genes in multiple developmental contexts, as well as in cancer and neurological and musculoskeletal diseases. In this review, we discuss the functions of BTB/POZ proteins during development with an emphasis on BTB‐zinc finger (BTB‐ZF) proteins, which play critical roles in transcriptional regulation and chromatin remodeling.
Severe avoidant/restrictive food intake disorder and coexisting stimulant treated attention deficit hyperactivity disorder
Authors: Pennell Alexandra , Couturier Jennifer , Grant Christina , Johnson Natasha 
Published: August 2016

ABSTRACTThere is a growing body of literature describing the development, clinical course, and treatment of avoidant/restrictive food intake disorder (ARFID), a diagnostic category introduced in the DSM‐5. However, information surrounding complex cases of ARFID involving coexisting medical and/or psychiatric disorders remains scarce. Here we report on two cases of young patients diagnosed concurrently with ARFID and attention deficit hyperactivity disorder (ADHD) who both experienced significant growth restriction following initiation of stimulant medication. The appetite suppressant effect of stimulants exacerbated longstanding avoidant and restrictive eating behaviors resulting in growth restriction and admission to an inpatient eating disorders unit. The implications of ARFID exacerbated by stimulant‐treated ADHD are explored, as well as the treatment delivered. These cases suggest that further research is needed to explore management options to counteract the appetite suppression effects of stimulants, while simultaneously addressing attention deficit symptoms and oppositional behavior. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:1036–1039)
Participant feedback from peer‐led, clinician‐led, and internet‐delivered eating disorder prevention interventions
Authors: Shaw Heather , Rohde Paul , Stice Eric 
Published: August 2016

ABSTRACTObjectiveThis article examines qualitative participant feedback to clinician‐delivered groups, peer‐delivered groups, and an Internet version of a dissonance‐based eating disorder prevention program from a controlled trial. These data have not been systematically examined and can inform the refinement and implementation of eating disorder prevention programs.MethodFeedback was collected from body dissatisfied young women (N = 680; M age = 22.2, SD = 7.1) randomized to a clinician‐led group, peer‐led group, Internet version of this prevention program or to an educational video.ResultsClinician and peer‐led group participants reported the group setting, feeling that they were not alone, and the letter exercise as most valuable; the most common response of what was less valuable was “none.” Many participants of the Internet version suggested increasing community support.ConclusionsFindings suggest the importance of considering the therapeutic value of group membership, and that online prevention programs could be enhanced by providing a mechanism for community support, such as an online forum. Results also inform selective prevention and suggest that screening potential participants to determine which delivery method best suits them should be considered. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:1087–1092)
Long‐range terrestrial laser scanning for geomorphological change detection in alpine terrain – handling uncertainties
Authors: Fey Christine , Wichmann Volker 
Published: August 2016

AbstractLong‐range terrestrial laser scanning (TLS) is an emerging method for the monitoring of alpine slopes in the vicinity of infrastructure. Nevertheless, deformation monitoring of alpine natural terrain is difficult and becomes even more challenging with larger scan distances. In this study we present approaches for the handling of spatially variable measurement uncertainties in the context of geomorphological change detection using multi‐temporal data sets. A robust distance measurement is developed, which deals with surface roughness and areas of lower point densities. The level of detection (LOD), i.e. the threshold distinguishing between real surface change and data noise, is based on a confidence interval considering the spatial variability of TLS errors caused by large laser footprints, low incidence angles and surface roughness. Spatially variable positional uncertainties are modelled for each point according to its range and the object geometry hit. The local point cloud roughness is estimated in the distance calculation process from the variance of least‐squares fitted planes. Distance calculation and LOD assessment are applied in two study areas in the Eastern Alps (Austria) using multi‐temporal laser scanning data sets of slopes surrounding reservoir lakes. At Finstertal, two TLS point clouds of high alpine terrain and scanned from ranges between 300 and 1800 m are compared. At Gepatsch, the comparison is done between an airborne laser scanning (ALS) and a TLS point cloud of a vegetated mountain slope scanned from ranges between 600 and 3600 m. Although these data sets feature different conditions regarding the scan setup and the surface conditions, the presented approach makes it possible to reliably analyse the geomorphological activity. This includes the automatic detection of rock glacier movement, rockfall and debris slides, even in areas where a difference in vegetation cover could be observed. Copyright © 2016 John Wiley & Sons, Ltd.
Modeling of drying kiwi slices and its sensory evaluation
Authors: Mahjoorian Abbas , Mokhtarian Mohsen , Fayyaz Nasrin , Rahmati Fatemeh , Sayyadi Shabnam , Ariaii Peiman 
Published: August 2016

AbstractIn this study, monolayer drying of kiwi slices was simulated by a laboratory‐scale hot‐air dryer. The drying process was carried out at three different temperatures of 50, 60, and 70°C. After the end of drying process, initially, the experimental drying data were fitted to the 11 well‐known drying models. The results indicated that Two‐term model gave better performance compared with other models to monitor the moisture ratio (with average R2 value equal .998). Also, this study used artificial neural network (ANN) in order to feasibly predict dried kiwi slices moisture ratio (y), based on the time and temperature drying inputs (x1, x2). In order to do this research, two main activation functions called logsig and tanh, widely used in engineering calculations, were applied. The results revealed that, logsig activation function base on 13 neurons in first and second hidden layers were selected as the best configuration to predict the moisture ratio. This network was able to predict moisture ratio with R2 value .997. Furthermore, kiwi slice favorite is evaluated by sensory evaluation. In this test, sense qualities as color, aroma, flavor, appearance, and chew ability (tissue brittleness) are considered.
The norepinephrine system affects specific neurophysiological subprocesses in the modulation of inhibitory control by working memory demands
Authors: Chmielewski Witold X. , Mückschel Moritz , Ziemssen Tjalf , Beste Christian 
Published: August 2016

AbstractInhibitory control processes are known to be modulated by working memory demands. However, the neurobiological mechanisms behind these modulations are inconclusive. One important system to consider in this regard is the locus coeruleus (LC) norepinephrine (NE) system. In the current study the role of the LC‐NE system by means of pupil diameter recordings that are integrated with neurophysiological (EEG) and source localization data were examined. A combined mental‐rotation Go/Nogo task was used. The results show that increases in working memory load complicate response inhibition processes. On a neurophysiological level these effects were reflected by specific modulations in event‐related potentials (ERPs) reflecting motor inhibition processes (i.e., Nogo‐P3). Attentional selection processes (reflected by the P1 and N1) as well as pre‐motor inhibition or conflict monitoring processes (reflected by the Nogo‐N2) were not affected. Activity of the LC‐NE systems, as indexed by the pupil diameter data, predicted neurophysiological processes selectively in the Nogo‐P3 time range. Source localization analyses suggest that this modulation occurs in the right middle and inferior frontal gyrus. The study provides evidence that the LC‐NE system is an important neurobiological system modulating the effects of working memory load on response inhibition processes. More specifically, it modulates a subset of dissociable cognitive processes that are related to prefrontal cortical regions. Hum Brain Mapp 38:68–81, 2017. © 2016 Wiley Periodicals, Inc.
Phase II study of the effectiveness and safety of trastuzumab and paclitaxel for taxane‐ and trastuzumab‐naïve patients with HER2‐positive, previously treated, advanced, or recurrent gastric cancer (JFMC45‐1102)
Authors: Nishikawa Kazuhiro , Takahashi Tsunehiro , Takaishi Hiromasa , Miki Akira , Noshiro Hirokazu , Yoshikawa Takaki , Nishida Yasunori , Iwasa Satoru , Miwa Hiroto , Masuishi Toshiki , Boku Narikazu , Yamada Yasuhide , Kodera Yasuhiro , Yoshida Kazuhiro , Morita Satoshi , Sakamoto Junichi , Saji Shigetoyo , Kitagawa Yuko 
Published: August 2016

Paclitaxel is a standard second‐line gastric cancer treatment in Japan. Trastuzumab could be active as second‐line chemotherapy for taxane/trastuzumab‐naïve patients with epidermal growth factor 2 (HER2)‐positive advanced gastric cancer. Patients aged ≥20 years with HER2‐positive, previously treated (except for trastuzumab and taxane), unresectable or recurrent gastric adenocarcinoma underwent combined trastuzumab (first and subsequent doses of 8 and 6 mg kg−1, respectively, every 3 weeks) and paclitaxel (days 1, 8, 15, every 4 weeks) treatment. Study endpoints were best overall response, progression‐free survival, overall survival, and safety. From September 2011 to March 2012, 47 Japanese patients were enrolled. Forty patients discontinued treatment after a median of 128.5 (range 4–486) days. Complete and partial responses were obtained in one and 16 patients (response rate of 37% [95% CI 23–52]), respectively. Median progression‐free survival and overall survival were 5.1 (95% CI 3.8–6.5) and 17.1 (95% CI 13.5–18.6) months, respectively. Grade 3/4 adverse events were neutropenia (32.6%), leukopenia (17.4%), anemia (15.2%) and hypoalbuminemia (8.7%). There was no clinically significant cardiotoxicity or cumulative toxicity. Three (disturbed consciousness, pulmonary fibrosis, and rapid disease progression) grade 5 events occurred. In conclusion, trastuzumab combined with paclitaxel was well tolerated and was a promising regimen for patients with HER2‐positive, previously treated, advanced or recurrent gastric cancer.
Hypoxia inducible factor 1 alpha down‐regulates type i collagen through Sp3 transcription factor in human chondrocytes
Authors: Duval Elise , Bouyoucef Mouloud , Leclercq Sylvain , Baugé Catherine , Boumédiene Karim 
Published: August 2016

AbstractCartilage engineering is one challenging issue in regenerative medicine. Low oxygen tension or hypoxia inducible factor‐1 (HIF‐1α) gene therapy are promising strategies in the field of cartilage repair. Previously, we showed that hypoxia and its mediator HIF‐1 regulate matrix genes expression (collagens and aggrecan). Here, we investigated the molecular mechanism involved in the regulation of type I collagen (COL1A1) by HIF‐1 in human articular chondrocytes. We show that HIF‐1α reduces COL1A1 transcription, through a distal promoter (−2300 to −1816 bp upstream transcription initiation site), containing two GC boxes that bind Sp transcription factors (Sp1/Sp3). Sp1 acts as a positive regulator but is not induced by HIF‐1. COL1A1 inhibition caused by HIF‐1 implies only Sp3, which accumulates and competes Sp1 binding on COL1A1 promoter. Additionally, Sp3 ectopic expression inhibits COL1A1, while Sp3 knockdown counteracts the downregulation of COL1A1 induced by HIF‐1. In conclusion, we established a new regulatory model of COL1A1 regulation by HIF‐1, and bring out its relationship with Sp3 transcription factor. In a fundamental level, these findings give insights in the mechanisms controlling COL1A1 gene expression. This may be helpful to improve strategies to impair type I collagen expression during chondrocyte differentiation for cartilage engineering. © 2016 IUBMB Life, 68(9):756–763, 2016
MicroRNA‐106b targets FUT6 to promote cell migration, invasion, and proliferation in human breast cancer
Authors: Li Nana , Liu Yuejian , Miao Yuan , Zhao Lifen , Zhou Huimin , Jia Li 
Published: August 2016

AbstractIt is demonstrated that the maladjustment of microRNA (miRNA) plays significant roles in the occurrence and development of tumors. MicroRNA‐106b‐5p (miR‐106b), a carcinogenic miRNA, is identified as a dysregulated miRNA in human breast cancer. In this article, the expression levels of miR‐106b were discovered to be particularly higher in breast cancer tissues than that in the corresponding adjacent tissues. Accordingly, miR‐106b was higher expressed in the breast cancer cell lines compared with that in the normal breast cell lines. Moreover, according to the data previously reported, increased expression of miR‐106b was significantly associated with advanced clinical stages and poor prognosis in breast cancer. Fucosyltransferase 6 (FUT6), a member of the fucosyltransferase (FUT) family, was found to have a reduced expression in tissues or cells with higher level of miR‐106b in breast cancer. Additionally, down‐regulation of miR‐106b increased the expression of FUT6 and resulted in an obvious decrease of cell migration, invasion, and proliferation in MDA‐MB‐231 cells. Furthermore, over‐expressed FUT6 reversed the impacts of up‐regulated miR‐106b on cell migration, invasion, and proliferation in MCF‐7 cells, indicating that FUT6 might be directly targeted by miR‐106b and serve as therapeutic targets for breast cancer. In brief, our results strongly showed that the low expression of FUT6 regulated by miR‐106b contributed to cell migration, invasion, and proliferation in human breast cancer. © 2016 IUBMB Life, 68(9):764–775, 2016