bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet‐derived microparticles and soluble factors differentially regulate human endometrial epithelial cell movement
Authors: Suginami Koh , Sato Yukiyasu , Horie Akihito , Matsumoto Hisanori , Tani Hirohiko , Mizumoto Yasunari , Ono Masanori , Matsuoka Ayumi , Kyo Satoru , Araki Yoshihiko , Konishi Ikuo , Fujiwara Hiroshi 
Published: February 2017

ProblemWe previously proposed that platelets promote re‐epithelialization during menstruation. As cell movement is one of the important cell behaviors in the process of tissue remodeling, we examined the effects of platelets on endometrial epithelial cell invasion.Method of StudyThe platelets were isolated from healthy women. Using a human endometrial epithelial cell‐derived immortalized cell line, EM‐E6/E7/hTERT cells, we examined the effects of platelets and platelet‐derived condition media with or without microparticles on the morphological and invasive properties of EM‐E6/E7/hTERT cells.ResultsPlatelets and microparticle‐containing conditioned media inhibited Matrigel invasion by EM‐E6/E7/hTERT cells along with an increase in cortical ring formation, whereas microparticle‐depleted conditioned media promoted their invasion without any significant changes of cortical ring formation.ConclusionThese results support our previous proposal and newly suggest the dual roles of platelets: platelet‐derived soluble factors that promote cell movement in the distant area, and microparticles that induce re‐epithelialization by endometrial epithelial cells in the proximal area.
Efficacy, safety and tolerability of the CCR1 antagonist BAY 86‐5047 for the treatment of endometriosis‐associated pelvic pain: a randomized controlled trial
Authors: Trummer Dietmar , Walzer Anja , Groettrup‐Wolfers Esther , Schmitz Heinz 
Published: February 2017

AbstractIntroductionAntagonism of CC chemokine receptor type 1 (CCR1) may provide a novel treatment approach for women with symptomatic endometriosis. Studies of CCR1 antagonists in these patients have not been reported.Material and methodsWomen (n = 110; 18–45 years) with symptomatic endometriosis were randomized to BAY 86‐5047 or placebo for 12 weeks. Pelvic pain was assessed using the visual analogue scale (VAS) and women recorded the intake of pain medication in a diary. The primary efficacy outcome was a composite of the absolute change in VAS score and the cumulative change in consumption of analgesics between baseline and the end of treatment. Safety assessments included adverse events, blood and urine evaluation and electrocardiography.ResultsMean VAS scores decreased from 64.8 mm at baseline to 49.2 mm at week 12 in the BAY 86‐5047 group and from 67.2 mm to 47.8 mm in the placebo group. The proportion of women using analgesics decreased from 33.9% to 11.5% or from 44.4% to 15.4% for patients who received BAY 86‐5047 or placebo, respectively. There was no significant difference between the two treatment groups in terms of change in VAS scores (p = 0.45) or intake of analgesics (p = 0.82). A three‐step sensitivity analysis failed to show superiority of BAY 86‐5047 over placebo (p = 0.67). BAY 86‐5047 was well tolerated and no significant safety concerns arose during the study.ConclusionsBased on these results, BAY 86‐5047 is unlikely to be useful in the treatment of women with endometriosis‐associated pelvic pain.
Review suggests that the immunoregulatory and anti‐inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to infants’ diets
Authors: Mermiri Despina‐Zoe T. , Lappa Theodora , Papadopoulou Athina L. 
Published: February 2017

AbstractFor years, the advice was to postpone introducing allergenic foods, in order to prevent food allergies. However, food allergies have escalated rather than declined and our review of the latest epidemiological, immunological and nutritional research suggests that early weaning practices may be beneficial. The most allergenic foods, such as fish, eggs and peanuts, have proved to be inherently rich in tolerogenic substances that can play a significant role in preventing allergies.ConclusionWe found evidence that the immunoregulatory and anti‐inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to both low‐risk and high‐risk infants.
Social and health‐related factors associated with refraining from seeking dental care: A cross‐sectional population study
Authors: Berglund Erik , Westerling Ragnar , Lytsy Per 
Published: February 2017

AbstractBackgroundSocial inequities are considered to affect healthcare utilization, whereas less is known about the factors associated with refraining from seeking dental care. This study aimed to investigate whether people with no social support, long‐term illness, caregiver burden and low socioeconomic status (SES) refrained from seeking dental care in higher proportion than the general Swedish population.MethodsThis study used cross‐sectional questionnaire data from repeated nationwide health surveys during 2004‐2013 of a total of 90 845 people. The questionnaire included questions on demographic characteristics, social support, long‐term illness, caregiving burden, SES and dental care‐seeking behaviour. Descriptive statistics, chi‐square tests, correlation analyses and logistic regressions were used to investigate associations between independent variables and dental care‐seeking behaviour.ResultsIn the total sample, 15.1% of respondents reported refraining from seeking dental care. Having no emotional social support or having no instrumental social support was separately associated with reporting refraining from seeking dental care in adjusted multivariate models (odds ratio [OR] 1.26, 95% confidence interval [CI] 1.18‐1.34 and OR: 1.89, 95% CI: 1.67‐2.13, respectively). Having a long‐term illness was associated with refraining from seeking dental care in adjusted models (adjusted OR: 1.43, 95% CI: 1.35‐1.51). Furthermore, being an informal caregiver was associated with refraining from seeking dental care (adjusted OR: 1.15, 95% CI: 1.07‐1.23). Low SES was associated with higher refraining from seeking dental care; the strongest association was with having financial problems (adjusted OR: 3.57, 95% CI: 3.19‐4.00). Interaction effects were found between education level and SES, and between social support and long‐term illness, and the outcome.ConclusionsThe findings in this study imply that having no social support, having long‐term illness, being informal caregiver or having financial problems are factors associated with reporting refraining from seeking dental care, on a population basis.
Relationship between epigenetic regulation, dietary habits, and the developmental origins of health and disease theory
Authors: Mochizuki Kazuki , Hariya Natsuyo , Honma Kazue , Goda Toshinao 
Published: February 2017

AbstractEnvironmental stressors during developmental stages are hypothesized to increase the risk of developing metabolic diseases such as obesity, type 2 diabetes, hypertension, and psychiatric diseases during later life. This theory is known as the Developmental Origins of Health and Disease (DOHaD). Recent studies suggest that accumulation of environmental stress, including those during developmental stages, is internalized as acquired information designated as “epigenetic memory.” This epigenetic memory is generally indicated as DNA methylation and histone modifications in the chromatin. In general, the demethylation of CpG islands induces histone acetylation and associated changes from heterochromatin to euchromatin, and enhances transcriptional activation. These changes are induced by the binding of transcriptional factors to cis‐elements located on promoter and enhancer regions and the associated binding of histone acetyl‐transferase and the transcription initiation complex. Recent studies have demonstrated novel epigenetic modifications that regulate transcription elongation steps by activating histone acetylation and bromodomain‐containing protein 4, which contains two bromodomains to bind acetylated histones, on the gene body (transcribed region). Gene expression alterations induced by carbohydrate signals and by changes in energy balance in the body are regulated by this model. In addition, induction of many metabolic genes, which are induced or reduced in adulthood by malnutrition during developmental stages, by intake of major nutrients, or development of lifestyle diseases in adulthood, are targeted by these novel epigenetic changes. In the present review, we introduce epigenetic regulations and the relationship with nutrient intake, and discuss links between epigenetic regulation and the development of metabolic diseases according to DOHaD.
Plasma biomarker levels and non‐obstructive coronary artery disease determined by coronary computed tomography angiography
Authors: Brolin Elin B. , Agewall Stefan , Cederlund Kerstin , Ekenbäck Christina , Henareh Loghman , Malmqvist Karin , Rück Andreas , Svensson Anders , Tornvall Per 
Published: February 2017

SummaryPurposeCoronary computed tomography angiography (CTA) and several circulating biomarkers have prognostic value regarding cardiovascular disease (CVD) events, but their association is incompletely studied. We aimed to investigate whether markers of lipid metabolism, inflammation and kidney function could predict non‐obstructive coronary artery disease (CAD) determined by coronary CTA, in a low‐to‐intermediate‐risk group.MethodsCoronary CTA and laboratory testing were performed for 115 subjects (45–70 years), with low prevalence of CVD risk factors, predominantly low‐to‐intermediate Framingham risk and normal or mildly reduced kidney function.ResultsForty‐nine (43%) had no CAD at coronary CTA, and 66 (57%) had CAD in ≥1 segment (stenosis < 50%). Adiponectin was inversely associated with CAD, and lipoprotein(a) and cystatin C were associated with CAD at coronary CTA. In multivariable logistic regression, cystatin C remained an independent predictor of CAD (OR: 2·50, 95% CI: 1·12–5·59). Cystatin C also correlated to the number of diseased segments (rs = 0·25, P<0·01).ConclusionHigher plasma levels of cystatin C were associated with non‐obstructive CAD at coronary CTA in subjects with low‐to‐intermediate CVD risk and normal to mildly reduced kidney function.
“Coerced Loss and Ambivalent Preservation”: Racial Melancholia in American Born Chinese
Authors: Sarigianides Sophia Tatiana 
Published: February 2017

AbstractRecent applications of Freud's theory examine the social value of the lost love object as a way of understanding the suffering of non‐majority groups. Rather than pathologizing the individual suffering the loss, the lens of racial melancholia pathologizes the discourse that constitutes racially marked others as alien to the majority. Through a close reading of image and text, Sophia Tatiana Sarigianides applies David Eng and Shinhee Han's theory of racial melancholia to Gene Luen Yang's graphic novel American Born Chinese. Sarigianides argues that texts such as American Born Chinese provide grounds for a public language for examining the suffering that ensues from the failure of assimilation as a desired outcome for immigrants in the United States.
Death by Numbers: A Response to Backer, Sarigianides, and Stillwaggon
Authors: Taubman Peter 
Published: February 2017

AbstractIn this response essay, Peter Taubman considers the relationship between melancholia and Freud's notion of a death drive. Taubman explores how audit culture sustains melancholia and intensifies the death drive, ultimately deadening our psyches by erasing memory, disparaging feelings, shutting down thought, and ignoring history. Taubman concludes with a suggestion that educators once again integrate discussions of Eros, or love, in their approaches to curriculum and teaching.
Damage by Neonectria neomacrospora and Adelges piceae in provenance trials of subalpine fir (Abies lasiocarpa) in Denmark
Authors: Skulason B. , Hansen O. K. , Thomsen I. M. , Talgø V. , Nielsen U. B. 
Published: February 2017

SummaryField trials of Abies lasiocarpa were undertaken with the aim of assessing the potential for Christmas tree production in Denmark. Twenty‐six provenances originating from Alaska to New Mexico were tested. Damage by the insect Adelges piceae and the fungus Neonectria neomacrospora was recorded for the first time 8 and 12 years after the initial planting. Damage from N. neomacrospora increased rapidly in the period 12–15 years after planting. Trees from the northern provenances and humid climates exhibited less damage than those from southern ones. Previous attack by A. piceae had a minor effect on N. neomacrospora infection. Greenhouse tests showed that detached shoots from healthy Abies lasiocarpa can be used to rank provenances for resistance to N. neomacrospora, but results varied according to host subspecies.
Models projecting the fate of fish populations under climate change need to be based on valid physiological mechanisms
Authors: Lefevre Sjannie , McKenzie David J. , Nilsson Göran E. 
Published: February 2017

AbstractSome recent modelling papers projecting smaller fish sizes and catches in a warmer future are based on erroneous assumptions regarding (i) the scaling of gills with body mass and (ii) the energetic cost of ‘maintenance’. Assumption (i) posits that insurmountable geometric constraints prevent respiratory surface areas from growing as fast as body volume. It is argued that these constraints explain allometric scaling of energy metabolism, whereby larger fishes have relatively lower mass‐specific metabolic rates. Assumption (ii) concludes that when fishes reach a certain size, basal oxygen demands will not be met, because of assumption (i). We here demonstrate unequivocally, by applying accepted physiological principles with reference to the existing literature, that these assumptions are not valid. Gills are folded surfaces, where the scaling of surface area to volume is not constrained by spherical geometry. The gill surface area can, in fact, increase linearly in proportion to gill volume and body mass. We cite the large body of evidence demonstrating that respiratory surface areas in fishes reflect metabolic needs, not vice versa, which explains the large interspecific variation in scaling of gill surface areas. Finally, we point out that future studies basing their predictions on models should incorporate factors for scaling of metabolic rate and for temperature effects on metabolism, which agree with measured values, and should account for interspecific variation in scaling and temperature effects. It is possible that some fishes will become smaller in the future, but to make reliable predictions the underlying mechanisms need to be identified and sought elsewhere than in geometric constraints on gill surface area. Furthermore, to ensure that useful information is conveyed to the public and policymakers about the possible effects of climate change, it is necessary to improve communication and congruity between fish physiologists and fisheries scientists.
Cultural influences in acquiescent response: A study of trainer evaluation biases
Authors: Chen Hsien‐Chun , Chen I‐Heng , Lin Szu‐Yin , Chen Yichieh 
Published: February 2017

AbstractThe current study is developed to identify factors that affect trainees’ acquiescent tendency in organizational trainer evaluations. We posit that conflict‐handling style affects ones tendency to acquiesce in trainer evaluations, and this relationship is regulated by cultural influence. Surveys were sent to employees with training experience in Taiwan and North America, 395 valid responses were collected. Results showed that the two individual conflict‐handling styles: non‐confrontation style and dominating style, are positively related to acquiescent tendency; and their relationship is found moderated by the influence of Confucian work dynamism, thus confirming the influence of cultural norms. Our findings contribute to HRD practitioners by highlighting the different conflict‐handling style and culture influence will result in different level of acquiescent propensity, trainer evaluations results should be interpreted more carefully and cautiously.
Contextualized personality measures in employee selection: Extending frame‐of‐reference research with job applicant samples
Authors: Fisher David M. , Cunningham Sydnie , Kerr Alison J. , Allscheid Steven P. 
Published: February 2017

AbstractThis study compared contextualized and non‐contextualized personality measures in operational hiring situations, unlike previous research which has largely relied on student or job incumbent samples. Comparisons were made with regard to (A) the frames‐of‐reference adopted by applicants when responding to the measures, (B) relations with subsequent employment interview scores, (C) applicant reactions, and (D) mean scores for the personality scales. The findings highlight potential concerns with using non‐contextualized personality measures for employee selection, as job applicants will likely adopt various frames‐of‐reference unrelated to the intended focus of measurement (i.e., work). Results also indicated that it may be premature to assume contextualized measures elicit improved applicant reactions despite their apparent job‐relatedness. The discussion concludes with suggested directions for future research.
The role of put option contracts in supply chain management under inflation
Authors: Wan Nana , Chen Xu 
Published: February 2017

AbstractThis paper considers a supply chain consisting of a supplier who manufactures one type of perishable products characterized by a long lead time and a retailer who purchases the products from the supplier and sells them to end consumers. In order to hedge against the risks of price and demand caused by inflation, portfolio contracts with put options, namely, a combination of wholesale price contracts and put option contracts, are adopted by the retailer to obtain the products from the supplier. We characterize the optimal ordering and production policies for the retailer and the supplier in the presence of put option contracts under inflation. By comparing with the case without put option contracts, we discuss the effect of put option contracts on the supply chain and prove that the usage of put option contracts benefits these two members under inflation. Through several numerical examples, we illustrate the effect of inflation on the supply chain with and without put option contracts. On this basis, we design a feasible supply chain coordination strategy based on put option contracts under inflation.
Exactness of the absolute value penalty function method for nonsmooth ‐invex optimization problems
Authors: Antczak Tadeusz 
Published: February 2017

AbstractIn this paper, the classical exact absolute value penalty function method is used for solving a new class of nonconvex nonsmooth optimization problems. Nonconvex nondifferentiable optimization problems with both inequality and equality constraints are considered here, in which not all functions constituting them have the fundamental property of convex functions and most classes of generalized convex functions—namely, a stationary point of such a function is its global minimum. It is proved for such nonconvex optimization problems that there exists a finite threshold of penalty parameters equal to the largest absolute value of a Lagrange multiplier such that, for every penalty parameter exceeding this lower bound, there is the equivalence between an optimal solution in the original constrained minimization problem with ‐invex functions and a minimizer in its associated penalized optimization problem with the exact l1 penalty function. Further, under nondifferentiable ‐invexity assumptions, a characterization of a saddle point of the Lagrange function, defined for the considered constrained optimization problem in terms of minimizers of its associated exact penalized optimization problem with the exact l1 penalty function, is presented.
Differential Gene Expression in Five Isolates of the Clam Pathogen, Quahog Parasite Unknown (QPX)
Authors: Rubin Ewelina , Tanguy Arnaud , Pales Espinosa Emmanuelle , Allam Bassem 
Published: February 2017

AbstractQuahog parasite unknown (QPX) is a thraustochytrid protist that infects the hard clam, Mercenaria mercenaria, causing significant economic losses along the northeastern coast of North America. Previous investigations noted differences in growth dynamics and virulence in QPX cells from different geographic locations. In order to probe the molecular determinants for these variations, we investigated the transcriptomic profiles of five geographically distinct QPX isolates using custom 15k 60‐mer oligonucleotide arrays. A total of 1,263 transcripts were differentially expressed (DE) among the five QPX isolates. The hierarchical clustering of gene expression profiles showed that the QPX isolates from Raritan Bay (RB, NY) and from Provincetown Harbor (MA) were more similar to each other and diverged from QPX isolates from Peconic Bay (PB, NY) and Old Plantation Creek (VA), which had more similar gene expression profiles. The most prominent difference was based on 78 transcripts coding for heat shock proteins DE between the five QPX isolates. The study generated contrasting transcriptomic profiles for QPX isolated from northern (MA) and deeper (RB, NY) locations as compared to southern (VA) and shallower (PB, NY) areas, suggesting the adaptation of the parasite to local environmental, in particular temperature, conditions.
Effect of meat aging on survival of MS2 bacteriophage as a surrogate of enteric viruses on lamb meat
Authors: Pezeshki P. , Yavarmanesh M. , Habibi Najafi M. B. , Abbaszadegan M. , Mohebbi M. 
Published: February 2017

AbstractThe objective of this study was to determine the role of meat aging process on survival of male specific bacteriophage MS2 on meat. MS2 was used as a viral surrogate to study the impact of aging on enteric viruses on lamb meat. They were spiked at concentration of 10, 103, and 105 pfu on lamb chops sliced into cuts of meats at 10 × 10 × 1.5 cm3, and were stored at 4 °C for 14 days. Physicochemical characteristics such as pH, oxidation‐reduction potential, water holding capacity and total count of mesophilic bacteria as well as MS2 were measured during the aging. The results indicated that the aging were not sufficient to completely inactivate all spiked MS2 on the lamb meat. However, physicochemical changes during muscle convert to meat significantly reduced MS2 survival (p < .05). The results also indicated that by increasing the spiked concentration of MS2, the survival rate of virus was significantly increased (p < .05).Practical applicationsMeat is one of the most consumed foods around the world that can be considered as a source of food borne illnesses. There are increasing concerns regarding zoonotic transmission of some animal enteric viruses which are closely related to human‐pathogenic strains via meat and other animal products. However, little research has been conducted on the survival of enteric viruses in meat. Given the novel results of this study, it can be concluded that although physicochemical changes during muscle conversion to meat reduced virus survival, aging process is not sufficient for complete inactivation of viruses. So, the safety of food depends on proper treatment processes and level of contamination of food products.