bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Study of Panitumumab in RAS Wild-Type Metastatic Adenocarcinoma of Small Bowel or Ampulla of Vater
Authors: Gulhati Pat , Raghav Kanwal , Shroff Rachna , Varadhachary Gauri , Javle Milind , Qiao Wei , Wang Huamin , Morris Jeffrey , Wolff Robert , Overman Michael J. 
Published: December 2017

Abstract

Lessons Learned
Panitumumab has no clinical activity in metastatic RAS wild-type small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC), possibly due to the foregut and midgut derivation of small bowel and ampulla. These results, along with findings from genomic characterization of SBA, suggest that SBA represents a unique intestinal malignancy and treatments should not be habitually extrapolated from colorectal cancer. Further studies evaluating the benefit of targeted therapies exclusively in SBA and AAC are warranted.

Background
Given the benefit of epidermal growth factor receptor (EGFR) monoclonal antibodies in colorectal cancer (CRC), we sought to evaluate the efficacy of panitumumab in metastatic RAS wild-type small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC).

Methods
We conducted a single-center, open-label, single-arm, Bayesian phase II trial. The primary objective was response rate (RR). Panitumumab was administered at a dose of 6 mg/kg intravenously (IV) every 14 days.

Results
Nine patients (male/female 7:2, median age: 61 years [range: 40–74], Eastern Cooperative Oncology Group [ECOG] performance status 0/1: 2/7) were enrolled from September 2013 to October 2015. One patient had AAC (pancreaticobiliary subtype) and eight patients had SBA (three duodenal, five jejunal/ileal). Acneiform rash was the most common toxicity. The study was stopped early due to futility with no responses, stable disease (SD) in two patients, and progression of disease (PD) in seven patients. Median progression-free survival (PFS) and overall survival (OS) were 2.4 and 5.7 months, respectively. No patients had extended RAS mutations (exons 2/3/4), but two patients had BRAF G469A and one patient had PIK3CA H1074R mutations.

Conclusion
Panitumumab had no clinically meaningful activity in patients with metastatic RAS wild-type SBA and AAC. Our findings may relate to the primarily midgut and foregut derivation of the small bowel and ampulla.
Lamiaceae de México
Authors: Martínez-Gordillo Martha Juana , Bedolla-García Brenda , Cornejo-Tenorio Guadalupe , Fragoso-Martínez Itzi , García-Peña María del Rosario , González-Gallegos Jesús Guadalupe , Lara-Cabrera Sabina I. , Zamudio Sergio 
Published: December 2017

Antecedentes: Lamiaceae es una de las familias con mayor riqueza de especies en México. Sin embargo, aún se carece de un estudio detallado sobre su diversidad en el país y de una revisión taxonómica global y actualizada. Como resultado, el aprovechamiento y conservación de los integrantes de esta familia es limitado.
Preguntas: ¿Qué avances se han logrado en el estudio y entendimiento de la riqueza, endemismo y distribución de las Lamiaceae mexicanas? ¿Qué estrategias deben ejecutarse para consolidar el conocimiento de la familia en el país?
Taxon: Lamiaceae
Sitio de estudio: México
Métodos: Se hizo una revisión exhaustiva de las Lamiaceae mexicanas en la literatura, bases de datos y herbarios. Se sintetizó el estado de su conocimiento. Se aplicaron análisis cuantitativos para evaluar su riqueza, endemismo y distribución geográfica.
Resultados: México cuenta con 33 géneros y 598 especies, de las cuales el 66.2 % son endémicas. El género más diverso es Salvia , con 306 especies. El estado más diverso es Oaxaca, mientras que Jalisco alberga el mayor número de especies endémicas.
Conclusiones: En México, Lamiaceae es la octava familia más diversa y el número de sus especies representa el 5.5 % de la familia a nivel mundial, por lo que el país puede considerarse uno de los centros de diversificación más importante. Debido a lo anterior, y al endemismo elevado que presenta, México es crucial para la conservación in situ de la familia. Si bien se ha logrado un avance considerable de su conocimiento y en la actualidad hay un repunte en su estudio, es necesario diversificar los campos de investigación.
Acesso aos serviços de saúde bucal de adultos e idosos
Authors: Nunes Camila Santa Rosa , Da Silva Marlucilena Pinheiro , Barcessat Ana Rita Pinheiro 
Published: December 2017

<p>O acesso aos serviços de saúde bucal é um campo de estudo relevante, pois permite inferir dados quanto à utilização e necessidade dos serviços, além de auxiliar no planejamento e na organização das ações de saúde. Trata-se de uma revisão integrativa cujo objetivo é sintetizar a produção cientifica brasileira acerca da acessibilidade dos usuários adultos e idosos aos serviços de saúde oral. A seleção foi baseada entre cruzamentos dos descritores: acesso aos serviços de saúde, saúde bucal e assistência odontológica, na base de dados Biblioteca Virtual em Saúde. Foram selecionados 20 artigos divididos por similaridade temática: acesso aos serviços de saúde geral, acesso aos serviços de saúde bucal de adultos, acesso aos serviços de saúde bucal de idosos. A partir deste levantamento identificou-se como fatores relacionados ao maior uso destes serviços: ser do sexo feminino, ter maior renda e escolaridade. A dor e a maior percepção de saúde são os maiores motivos para a procura de atendimento. A efetivação de um acesso equitativo é um desafio para o Sistema de Saúde e o desenvolvimento de estudos que busquem conhecimento desses fatores é de suma importância para a redução dessas desigualdades.</p>
Physics teaching methods: an analysis on peer instruction and modeling instruction
Authors: Souza Lucas Matheus Araújo Trajano de , Matos Robert Saraiva 
Published: December 2017

<p>There is a well known phenomenon related to physics students that concerns the difficulty that these have to understand conceptually what is being taught, since, not infrequently, these show bad results and learning difficulties. Based on this, the present article aim a literature review on different learning methods of physics teaching, among them, two in particular, the Peer Instruction and the Modeling Instruction. While in Peer Instruction the students meet with colleagues and discuss a certain theme among them, in most cases with conceptual testes, the Modeling Instruction is based on the use of interactive whiteboards and exposition of content through the student itself, as well as recommends experiments and other sources of pedagogical support. Many authors advocate that the student, even those with low performance in his classes, can learn better when they work in a interactive way or when they work with their peers. It is starting on this premise that studies in these subjects are based. </p>
Expected Prescription Error (EPE) Scores of Cancer Drugs in Egypt: A New Method of Data Extraction from a Questionnaire Based Study
Authors: Omar Abdel-Rahman,L. Elwakil Mahmoud Abbass Ellithy, Doaa Atef Soliman, , El-Baghdady N.S. , , Wesam R. ELghamry Wesam Moustafa El Bakly. 
Published: December 2017

Registration Details Of The Current Study: The current study is a part of a research registered on www.clinicaltrial.gov NCT02630979. The study received approval from the Institutional Review Board (IRB) of the Clinical Oncology department. Faculty of Medicine, Ain Shams University in October 2015.
Sources Of Support: There is no source of support of any type either financial or technical received by the authors of this study to implement this study. No source of funding from National Institutes of Health (NIH); Welcome Trust; Howard Hughes Medical Institute (HHMI); or other(s).
“Adão e Eva no Paraíso”: a força dominadora do símbolo no dizer de um conto de Eça de Queirós
Authors: Leonido Levi Fernandes , Morgado Elsa Maria , Rodrigues João Bartolomeu , Pereira Luciana Cabral 
Published: December 2017

«Adão e Eva no Paraíso» é um conto de Eça de Queirós. Nele trava-se um interessante diálogo entre duas visões epistemológicas em permanente confronto: por um lado a Bíblica, representante do criacionismo e, por outro, a perspetiva evolucionista. Eça trava, assim, um interessante diálogo entre as duas perspetivas referidas, nunca excluindo uma em detrimento da outra, assumindo uma posição neutra. A tetractis pitagória serve de estrutura formal ao conto. Esta pirâmide é preenchida e ornamentada com os recursos e a força dominadora que os símbolos lhe emprestam: por um lado, os números concorrem para compor as sequências temporais (da criação e da evolução) que compõem o enredo; por outro, a simbologia dos elementos vai fazendo subir, degrau a degrau, o estado de hominização de Adão, na complementaridade de Eva que bate as pedras da civilização, rumo à perfeição que se manifesta na atividade artística.
Using Ferric Oxide and Silica Nanoparticles To Develop Modified Calcium Bentonite Drilling Fluids
Authors: Mahmoud Omar , Nasr-El-Din Hisham A. , Vryzas Zisis , Kelessidis Vassilios C. 
Published: December 2017

Summary
One of the important functions of drilling fluids is to form a filter cake, which minimizes leakoff of drilling fluids into the formation. Drilling-fluid invasion can cause formation damage, but good-quality filter cake can reduce such damage. This research focuses on the laboratory techniques and performance results of testing innovative calcium-bentonite-based drilling fluids containing nanoparticles (NPs) for minimizing formation damage during drilling in harsh environments.
A rotational viscometer was used to measure the rheological properties of the tested fluids. ζ-potential measurements were conducted at different NP concentrations to assess their stability and to investigate the role of charge potential. Indiana limestone outcrop disks were examined as the filter media for both static and dynamic filtration (up to 350°F and 500 psi) using a filter press. The filter cakes were examined using a computed-tomography (CT) scan and scanning-electron-microscopy energy-dispersive spectroscopy (SEM-EDS). Inductively coupled plasma optical-emission spectrometry (ICP-OES) was used to measure the concentrations of key ions in the filtrate fluids.
A reduction of 43% in the filtrate-fluid volume was achieved when adding 0.5 wt% of ferric oxide NPs compared with that of the base fluid. However, using silica NPs led to an increase in the filtrate volume and filter-cake thickness. Using 0.5 wt% of ferric oxide NPs provided less agglomeration and reduced the filter-cake permeability. In addition, the SEM-EDS and ICP-OES analysis showed a replacement of the cations dissociated from the bentonite by NPs, which promoted the formation of a rigid clay-platelet structure. The produced filter cakes consisted of two layers, as indicated by the CT-scan analysis. Increasing the concentration of NPs resulted in an increase in the fluid loss and filter-cake thickness. At a higher NP concentration (2.5 wt%), a third layer of NPs was observed, which adversely affected the filter-cake characteristics, as demonstrated by CT-scan analysis and SEM-EDS elemental mapping. Furthermore, the NP-bentonite fluids had stable rheological properties at different temperatures (up to 200°F) and NP concentrations. In addition, aging these fluids at 350°F for 16 hours showed minor changes in the rheological properties.
This research work provides an experimental evaluation of improved calcium-bentonite-based fluids using NPs under downhole conditions. The ferric oxide NPs have the potential to enhance the properties of calcium bentonite, as a low-cost alternative, to perform well in an application where the higher-value sodium bentonite is commonly used, which could provide more-efficient drilling operations and less formation damage.
A Lean Sigma Approach to Well Stimulation on Barrow Island, Australia
Authors: O'Reilly D. I. , Hopcroft B. S. , Nelligan K. A. , Ng G. K. , Goff B. H. , Haghighi M.. 
Published: December 2017

Summary
Barrow Island (BWI), 56 km from the coast of Western Australia (WA), is home to several mature reservoirs that have produced oil since 1965. The main reservoir is the Windalia Sandstone, and it has been waterflooded since 1967, whereas all the other reservoirs are under primary depletion. Because of the maturity of the asset, it is economically critical to continue to maximize oil-production rates from the 430 online, artificially lifted wells. It is not an easy task to rank well-stimulation opportunities and streamline their execution. To this end, the BWI Subsurface Team applied the Lean Sigma processes to identify opportunities, increase efficiency, and reduce waste relating to well stimulation and well-performance improvement.
The Lean Sigma methodology is a combination of Lean Production and Six Sigma, which are methods used to minimize waste and reduce variability, respectively. The methods are used globally in many industries, especially those involved in manufacturing. In this asset, we applied the processes specifically to well-performance improvement through stimulation and other means. The team broadly focused on categorizing opportunities in both production and injection wells and ranking them—specifically, descaling wells, matrix acidizing, sucker-rod optimization, reperforating, and proactive workovers. The process for performing each type of job was mapped, and bottlenecks in each process were isolated.
Upon entering the “control” phase, several opportunities had been identified and put in place. Substantial improvements were made to the procurement, logistics, and storage of hydrochloric acid (HCl) and associated additives, enabling quicker execution of stimulation work. A new program was also developed to stimulate wells that had recently failed and were already awaiting workover (AWO), which reduced costs. A database containing the stimulation opportunities available at each individual well assisted with this process. The project resulted in the stimulation of several wells in the asset, with sizable oil-rate increases in each.
This case study will extend the information available within the oil-industry literature regarding the application of Lean Sigma to producing assets. It will assist other operators when evaluating well-stimulation opportunities in their fields. Technical information will be shared regarding feasibility studies (laboratory-compatibility work and well-transient-testing results) for acid stimulation and steps that can be taken to streamline the execution of such work. Some insights will also be shared regarding the most-efficient manner to plan rig work regarding stimulation workovers.
Effects of phenol on sulfate reduction by mixed microbial culture: kinetics and bio-kinetics analysis
Authors: Mohanty Mohit Prakash , Brahmacharimayum Bharati , Ghosh Pranab Kumar 
Published: December 2017

Abstract
Mixed microbial culture collected from the wastewater treatment plant of Indian Institute of Technology Guwahati (IITG) was further grown in anaerobic condition in presence of sulfate where lactate was added as a carbon source. Sulfate addition was increased stepwise up to 1,000 mg l−1 before phenol was added at increasing concentrations from 10 mg l−1 to 300 mg l−1. Kinetics of sulfate, phenol and chemical oxygen demand reduction were studied and experimental findings were analyzed using various bio-models to estimate the bio-kinetic coefficients. This is the first detailed report on kinetics and bio-kinetic studies of sulfate reduction in presence of phenol. Experimental results showed that there was no inhibition of sulfate reduction and microbial growth up to 100 mg l−1 phenol addition. However, inhibition to different degrees was observed at higher phenol addition. The experimental data of microbial growth and substrate consumption in presence of phenol fitted well to the Edward model (R2 = 0.85, root mean square error = 0.001011) with maximum specific growth rate = 0.052 h−1, substrate inhibition constant = 88.05 mg l−1 and half saturation constant = 58.22 mg l−1. The characteristics of the cultured microbes were determined through a series of analysis and microbial tests.
Khat (Catha Edulis) as a Risk Factor for Cardiovascular Disorders: Systematic Review and Meta-Analysis
Authors: Mega Teshale Ayele , Dabe Nikodimos Eshetu 
Published: December 2017

Background:About 20 million people worldwide are believed to be using khat. Although some studies reported that khat chewing might result in cardiovascular disorders, conclusive evidence is limited.Method:The objective of this review was to synthesize the best available evidence for the effect of khat on the cardiovascular system. Databases searched were PubMed, Cochrane database of systematic reviews, CINAHL, poplin, LILACS, MedNar and Scopus. All papers included in the review were subjected to rigorous appraisal using the Joanna Briggs Institute (JBI) standardized critical appraisal tool. Review Manager Software (Revman 5.3) was used for meta-analysis and effect size and the 95% confidence interval (CI) was calculated.Result:Data was extracted from 10 articles. Our meta-analysis included 9,207 subjects, (2123 chewers and 7084 non-chewers, respectively) to elucidate the effect of khat on heart rate, diastolic and systolic blood pressure. The mean diastolic and systolic blood pressure of khat chewers was higher than the non-chewers with a mean difference of 5.1 mmHg, 95%CI [2.7,7.5] and 7.9 mmHg, 95%CI [2.65, 13.18], respectively. Similarly, the heart rate of the chewers remained consistently higher, making the mean difference of 6.9 beats/min, 95%CI [0.5, 13.3]. In addition, khat was found to have either a causative or worsening effect on stroke, myocardial infarction and heart failure.Conclusion:We showed that khat chewing could significantly affect the cardiovascular system through its effect on heart rate and blood pressure. Therefore, health promotion should be aimed to encourage quitting khat chewing.
Multi-Centre Clinical Evaluation of Photothermal Radiometry and Luminescence Correlated with International Benchmarks for Caries Detection
Authors: Silvertown Josh D. , Abrams Stephen H. , Sivagurunathan Koneswaran S. , Kennedy Julia , Jeon Jinseok , Mandelis Andreas , Hellen Adam , Hellen Warren , Elman Gary , Ehrlich Richard , Chouljian Raffy , Finer Yoav , Amaechi Bennett T. 
Published: December 2017

Introduction:A clinical study was initiated to investigate a caries detection device (The Canary System (CS)), based on photothermal radiometry and modulated luminescence (PTR-LUM). The primary objective of this study was to determine if PTR-LUM values (in the form of Canary Numbers; CN) correlate with International Caries Diagnostic and Assessment System (ICDAS II) scores and clinical situations. The secondary objectives of this study were to monitor the safety of PTR-LUM, and collect data to determine how CN values could be used to differentiate healthy from decayed tooth surfaces on a normalized scale.Methods:The trial was a four site, non-blinded study. Data was collected from 92 patients, resulting in 842 scanned tooth surfaces over multiple appointments. Surfaces were assessed according to ICDAS II, and further stratified into five clinical situation categories: 1) healthy surface, 2) non-cavitated white and/or brown spots; 3) caries lesions; 4) cavitation and 5) teeth undergoing remineralization therapy.CN data was analyzed separately for smooth and occlusal surfaces. Using a semi-logarithmic graph to plot raw CN (rCN) and normalized (CN) values, rCN data was normalized into a scale of 0-100.Results:Linear correlations (R2) between CN and ICDAS II groupings for smooth and occlusal surfaces were calculated as 0.9759 and 0.9267, respectively. The mean CN values derived from smooth (20.2±0.6) and occlusal (19±1.0) surfaces identified as healthy had significantly lower CN values (P<0.05) compared with the values from the other clinical situation categories. No adverse events were reported.Conclusion:The present study demonstrated the safety of PTR-LUM for clinical application and its ability to distinguish sound from carious tooth surfaces. A clear shift from the baseline in both PTR and LUM in carious enamel was observed depending on the type and nature of the lesion, and correlated to ICDAS II classification codes, which enabled the preliminary development of a Canary Scale.
PENGUJIAN KUALITAS KELAYAKAN PERANGKAT LUNAK DENGAN PENERAPANPERANCANGAN MODEL RAPID APPLICATION DEVELOPMENT
Authors: Hidayat Hari Toha 
Published: December 2017

Membangun suatu perangkat lunak yang berkualitas tidaklah mudah. Banyak hal yang harus diperhatikan dalam membuat suatu perangkat lunak yang berkualitas. Semakin berkualitas suatu perangkat lunak atau aplikasi maka akan semakin mahal harga yang dijual. Perangkat lunak yang berkualitas tidak hanya sekedar mencari keuntungan belaka akan tetapi mutu dari kualitas dan kuantitasnya yang sudah menjadi jaminan dari aplikasi yang ditawarkan. Pembuatan suatu perangkat lunak yang berkualitas selalu memperhatikan kebutuhan akan penggunanya, sehingga mampu memberikan solusi dari permasalahan yang dihadapi oleh para penggunanya. Selain itu, suatu aplikasi yang berkualitas selalu melalui tahapan – tahapan pengujian yang tidak singkat sehingga benar – benar menjamin akan kualitas produknya. Nilai yang diperoleh dari pengujian untuk kelengkapan fitur diperoleh nilai standard error terkecil yakni 0,008 dan error tertinggi yakni 0,058. Untuk variabel kemudahan penggunaan dengan standar error terkecil 0,013 dan tertinggi 0,063. Variabel yang terakhir diuji yakni fleksibilitas dengan nilai error terkecil 0,015 dan tertinggi 0,035. Berdasarkan penelitian yang sudah dilakukan maka dapat disimpulkan bahwa pada pembuatan sistem informasi akuntansi biaya operasional Sekolah (SIA BOS) dinyatakan layak digunakan oleh pengguna.
ANALISIS DATA TIME SERIES DAN VCR KEPADATAN LALU LINTAS (STUDI KASUS: JALAN ADISUCIPTO DEPAN AMBARUKMO PLAZA)
Authors: Wibowo Arief Rahma 
Published: December 2017

Kepadatan lalu lintas atau biasa dikenal dengan istilah kemacetan merupakan kondisi dimana terjadinya penumpukan kendaraan disuatu ruas jalan tertentu, hal ini bisa saja disebabkan oleh beberapa faktor, antara lain jumlah kendaraan yang berada dalam ruas jalan tersebut. Sumber data dari riset ini langsung diperoleh dari Dinas Perhubungan DIY. Analisis data time series digunakan untuk meramalkan jumlah kendaraan pada siang hari dan analisis VCR disini untuk klasifikasi kondisi jalan tersebut. Berdasarkan analisis data time series menggunakan metode trend, data jumlah motor yang melalui Jalan Adisucipto pada pukul 12.30-14.40 cenderung mengalami penurunan. Berdasarkan analisis VCR, jumlah kendaraan mencapai puncaknya pada pukul 15.30-17.00 dan termasuk pada kelas F (sangat butuk), yaitu kondisi arus dipaksakan, kecepatan rendah, volume diatas kapasitas dan antrian panjang (macet).