bluuebunny/crossref_metadata_2025_split huggingface dataset:
Composition of Amesiodendron chinense (Merr.) Hu Seed Oil and Assessment of Its Nrf2/ARE Induction Activity in AREc32 Cells
Authors: Khuniad Chuanchom , Nahar Lutfun , Birkett Jason W. , Ritchie Kenneth J. , Sarker Satyajit D. 
Published: October 2024

Article
Composition of Amesiodendron chinense (Merr.) Hu Seed Oil and Assessment of Its Nrf2/ARE Induction Activity in AREc32 Cells

Chuanchom Khuniad 1,2,*, Lutfun Nahar 3,*, Jason W. Birkett 4, Kenneth J. Ritchie 1 and Satyajit D. Sarker 1,*

1 Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
2 Department of Thai Traditional Medicine, Faculty of Health and Sports Science, Thaksin University, Phatthalung 93210, Thailand
3 Laboratory of Growth Regulators, Palacký University and Institute of Experimental Botany, The Czech Academy of Sciences, Šlechtitelů 27, 78371 Olomouc, Czech Republic
4 Forensic Science Research Group, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
* Correspondence: C.Khuniad@2020.ljmu.ac.uk (C.K.); nahar@ueb.cas.cz (L.N.) and S.Sarker@ljmu.ac.uk (S.D.S.)
Received: 7 April 2024; Revised: 26 April 2024; Accepted: 6 May 2024; Published: 14 May 2024

Abstract: Background: Amesiodendron chinense (Merr.) Hu (family: Sapindaceae) is a Thai medicinal plant. The seed oil of this species has been used by folk healers and local people in southern Thailand for the treatment of wounds, skin disorders and common hair problems. This study aimed at the GC-MS-based determination of the chemical composition of the seed oil of this plant, and evaluation of its Nrf2/ARE induction activity in AREc32 cells (modified human breast cancer cell line MCF-7) using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] and luciferase reporter gene assays. Results: GC-MS analysis identified 9-(E)-octadecenoic acid (84.82%) as the main component of this seed oil. TLC-based qualitative DPPH (2,2-diphenyl-1-picrylhydrazyl) assay revealed the DPPH radical-scavenging activity of the seed oil and its chromatographic fractions. A low-level DPPH-scavenging activity was observed in the quantitative assay, but no IC50 value could be determined even with the highest tested concentration (10 mg/mL). Neither the oil nor its chromatographic fractions showed any significant Nrf2/ARE induction in AREc32 cells. The seed oil was noncytotoxic against the AREc32 cells. Conclusions: A. chinense seed oil and its fractions had a low level of free-radical scavenging property but no significant Nrf2/ARE induction activity in AREc32 cells. However, as the oil did not show any cytotoxicity at test concentrations in the MTT assay, this oil might potentially be safe to use in cosmetic formulations or as a vehicle for the dermal delivery of drug molecules.
Evaluation of Terminalia arjuna Bark Powder Supplementation on Isoprenaline-Induced Oxidative Stress and Inflammation in the Heart of Long Evans Rats, Understanding the Molecular Mechanism of This Old Medicinal Plant
Authors: Alimullah Mirza , Rahman Nafiur , Sornaker Puspa , Akramuddaula Kazi , Sarif Sumaia , Siddiqua Shahnaz , Mitu Kaniz Fatima , Jahan Ishrat , Khan Ferdous , Subhan Nusrat , Alam Md. Ashraful 
Published: October 2024

Article
Evaluation of Terminalia arjuna Bark Powder Supplementation on Isoprenaline-Induced Oxidative Stress and Inflammation in the Heart of Long Evans Rats, Understanding the Molecular Mechanism of This Old Medicinal Plant

Mirza Alimullah 1, Nafiur Rahman 1, Puspa Sornaker 1, Kazi Akramuddaula 2, Sumaia Sarif 1, Shahnaz Siddiqua 3, Kaniz Fatima Mitu 1, Ishrat Jahan 1, Ferdous Khan 1, Nusrat Subhan 1 and Md. Ashraful Alam 1,*

1 Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh
2 Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh
3 Department of Pharmacy, East West University, Dhaka 1212, Bangladesh
* Correspondence: ashraful.alam@northsouth.edu or sonaliagun@yahoo.com

Received: 27 July 2024; Revised: 28 August 2024; Accepted: 28 August 2024; Published: 5 September 2024

Abstract: This study was conducted to determine the effect of Terminalia arjuna bark powder supplementation on the oxidative stress of the cardiovascular system. Isoprenaline (ISO) was administered to the rats to develop the cardiac hypertrophy and myocardial infarction (MI). Terminalia arjuna bark powder was mixed with the food powder and provided for two weeks. At the end of the experiment, all rats were sacrificed and tissue samples were collected. ISO administration in rats increased the oxidative stress markers such as malondialdehyde (MDA), nitric oxide (NO), advanced oxidation protein product (APOP), and myeloperoxidase (MPO) in plasma and heart. Terminalia arjuna bark powder lowered the MDA, NO, and AOPP concentration level in ISO administered rats. Additionally, Terminalia arjuna restored the antioxidant enzymes (catalase and SOD) activities. Gene expression of antioxidant enzymes and inflammatory markers in the heart were studied. Terminalia arjuna restored Nrf-2, HO-1, HO-2, catalase, SOD, and GPx gene expression in the heart of ISO administered rats. ISO induced increased transcription levels of inflammatory genes such as IL-1, IL-6, TNF-α, TGF-β, iNOS, and NF-κB, which were decreased by Terminalia arjuna bark powder. Histopathology was checked and hematoxylin and eosin and Sirius red staining were performed on heart sections. ISO administration resulted in mononuclear cells infiltration and collagen deposition in the heart which were lowered by Terminalia arjuna bark powder. In conclusion, this study suggests that the Terminalia arjuna bark powder alleviated the oxidative stress by restoring the antioxidant genes and prevented the increase in inflammatory markers in the heart of ISO administered rats.
Effect of adding dune sand to tuff in Saharan road construction
Authors: Mustapha Akacem , M’hammed Abdeldjalil , Hassan Moulay Omar , Driss Djaafari , Lyacine Bennacer , Mohammed Abbou , Khedidja Belaidi 
Published: October 2024

The south region of Algeria is characterized by a wide surface, a scattered population and a very small ratio of road length per habitant. To allow the development of agricultural, industrial and touristic activities between different cities in the south of Algeria, it is necessary to maintain and to develop the road infrastructure. However the development of these infrastructures necessitates the use of huge amount of certified aggregates from quarries which is not available in the vicinity of the need. For these raisons, in the framework of sustainable development, a strategy which consists in using local materials like fine sediments (dune sand) and other types of material is engaged. The materials constituting the road layers, until today, have been limited to certain so-called noble materials (gravel, aggregates, etc.), but these are being depleted as a result of the intensive exploitation and the scarcity of quality careers. Gypso-limestone encrustation tuffs, the most used materials in pavements (base course and base course) in the Saharan areas such as southern Algeria, have shown acceptable behavior for many years until these last days, when this type of material begins to present certain limits under the effect of the intensity of the traffic. In order to promote the abundant wind sands in these regions, we are interested in developing the dune sands in the pavement as a mixture with the tuffs. The present work presents a contribution to the study of the behavior of the tuff of the Adrar region (South of Algeria) alone and mixed with the sand dunes in different formulations. The aim is to evaluate the evolution of mechanical properties including resistance to simple compression, the ability to compaction and punching (RBC). The work also discusses the influence of the addition of cement in low levels on the performance of the mixture.
Behavior of recycled aggregates treated with cement paste with respect to capillary absorption and flexion
Authors: Belguesmia Khalil , Guerzou Tourkia , Mebrouki Abdelkader , Belas Nadia , Safer Omar , Belaribi Omar , Mostefa Fouzia , Amer Adem Ait Mohamed 
Published: October 2024

Recycling waste from destroyed structure as a new resource of aggregates has several technical, economic and environmental advantages although it should be noted that these aggregates have disadvantages which can reduce the mechanical concrete properties, one of the most important is the water absorption problem. The waste valorisation industry stands as an alternative solution, effectively managing waste while also preserving natural resources. In this context, the present study consists to recover waste resulting from demolition of old Sonalgaz (Electrical poles) columns built in 1947 in the wilaya of Mostaganem. The obtained aggregates are enveloped by the old cement paste, which is known for its porous nature, resulting in a significant water absorption capacity. For that purpose, it was advisable to determine the required absorbed water quantity to saturate a specific recycled aggregates (RA) volume. In this work, we have opted for the method of cement paste treatment of the aggregates 3/8 mm and 8/16 mm. This method involves covering them by a film of cement paste and letting them dry for 28 days. Additionally, this study includes an analysis of the physical properties of natural and recycled aggregates, both before and after treatment, along with their impact on the mechanical properties of concrete mixes containing fully pre-saturated aggregates (100% RA) and a blend of half recycled and half natural aggregates (50% RA + 50% NA). These results are compared to reference concrete made solely with 100% natural aggregates (NA).
Nonlinear control of the permanent magnet synchronous motor PMSM using input-output linearization control and sliding mode control
Authors: Seddik Mahgoun Mohamed , Essalam Badoud Abd 
Published: October 2024

Today, electric machines are becoming increasingly important in all sectors (industrial drives, the automotive industry, aviation, traction systems, and agriculture, etc.). Among these machines, permanent magnet synchronous machines (PMSMs) hold a significant place in the control of industrial mechanisms, automated systems, and in the fields of renewable energy like (wind energy, solar energy, and hybrid systems, etc ). Currently, in variable speed drives, the use of PMSM, especially for low power and certain special industrial applications, is replacing DC motors and asynchronous motors because they offer higher efficiency, power factor, and torque density. Moreover, PMSM do not have an excitation circuit in the rotor, which leads to reduced maintenance demands. The control of permanent magnet synchronous machines (PMSM) presents significant challenges due to their nonlinear behavior. Classical linear controllers, such as PI, perform well with linear systems that have constant parameters. However, for nonlinear systems with varying parameters, the conventional control methods may prove insufficient and exhibit a lack of robustness. To address the issues and achieve decoupled machine control, various methods have been proposed. Nonlinear robust control techniques have been extensively explored within the domain of power electronics and drive systems. Included in these, sliding mode control and nonlinear input-output feedback linearization (IOFL). Sliding mode control (SMC) is a control technique known for its excellent dynamic performance in PMSM drives. It offers high robustness and straightforward implementation in both software and hardware. However, a significant drawback of this method is the chattering phenomenon. By the way the input/output linearization control can provide good behavior in steady and dynamic regimes and also provides good decoupling between system variables. This article presents a design of tow control laws based on sliding mode and feedback linearization controller based on input-output feedback linearization to adjust the speed of a permanent magnet synchronous motor (PMSM). To highlight the effectiveness of the designed controllers, a comparison was carried out Matlab Simulink, revealing that the feedback linearization controller outperforms the SMC.
Reconstrução cirúrgica com retalhos musculares e musculocutâneos no tratamento de osteomielite pós-traumática: resultados e complicações
Authors: Maia Matheus Varonil Alencar , Moreira Márcia Maria Barros 
Published: October 2024

A osteomielite é uma infecção óssea grave causada principalmente por bactérias, como Staphylococcus aureus (incluindo MRSA) e Pseudomonas aeruginosa. A condição pode ser consequência de traumas, cirurgias ortopédicas ou infecções hematogênicas, sendo comum em casos crônicos. O tratamento combina desbridamento cirúrgico, antibioticoterapia prolongada e, frequentemente, reconstrução tecidual. Retalhos musculares e musculocutâneos são eficazes para cobrir defeitos complexos devido à sua boa vascularização, o que melhora o combate à infecção. No entanto, complicações como necrose de retalhos e necessidade de reintervenções ainda são desafios. O estudo avalia os resultados clínicos e cirúrgicos de pacientes com osteomielite pós-traumática tratados com essas técnicas de reconstrução. Objetivo: Avaliar os resultados clínicos e cirúrgicos de pacientes com osteomielite pós-traumática tratados com reconstrução por retalhos musculares e musculocutâneos, e as complicações associadas. Métodos: Estudo retrospectivo com análise dos registros de pacientes submetidos a reconstrução com retalhos musculares e musculocutâneos após desbridamento ortopédico. Foram avaliados desfechos clínicos, complicações e tempo de internação. Resultados: A reconstrução cirúrgica foi eficaz na maioria dos casos, com boa resposta à terapia antimicrobiana. Observou-se uma taxa de complicações de 40%, incluindo deiscências de sutura e necrose parcial de retalhos. O tempo de internação foi mais prolongado em pacientes com infecções polimicrobianas. Conclusão: A reconstrução com retalhos musculares e musculocutâneos, combinada com desbridamento adequado, proporciona bons resultados em osteomielite pós-traumática. No entanto, a alta taxa de complicações e a necessidade de reintervenções reforçam a importância de um acompanhamento pós-operatório rigoroso.
Como negociações tributárias e estratégias de logística podem otimizar os custos logísticos de negócios online na região norte do Brasil?
Authors: Souza Camilly Oliveira Bessa de , Souza Giovana Melo Abreu de , Gomes Maria Eduarda Barroso , Rodrigues Tarcísio Matheus Freitas , Roberto José Carlos Alves , Pinto Junior José Roberto Lira 
Published: October 2024

O presente trabalho foi realizado a partir de um diagnóstico organizacional realizado na empresa WN Odonto Medical, localizada na cidade de Manaus, estado do amazonas, classificada como uma empresa de médio porte e atua no ramo de varejo de produtosmédico hospitalares, tem com fim investigar a respeito de como a otimização de custos logísticos em um negócio online sediado na região Norte do Brasil pode ser alcançada por meio de negociação tributária e estratégias logísticas. O tipo de pesquisa foi quali quantitativa, de natureza exploratória, utilizando o 5W2H e o software Bizagi Process Modeler para a modelagem de processos. A análise demonstrou que os principais desafios da empresa WN Odonto Medical são o alto custo do frete, tributos pagos e a ineficiência na gestão de estoques. Como resultado, ações como negociação de incentivos fiscais regionais, otimização do estoque e estabelecimento de parcerias estratégicas com transportadoras locais foram sugeridas. Pode-se concluir que a execução dessas estratégias reduzirá significativamente as despesas logísticas e aumentará a competitividade da empresa, tornando-se um exemplo para outras organizações em uma região semelhante.
Foreign national legislation on combating domestic violence
Authors: Kukeyev A. K. 
Published: October 2024

This article examines the foreign experience of bringing to justice for domestic violence. Domestic violence definitely falls under the violation of a large number of internationally recognized human rights that the State is obliged to defend and protect: the right to life and physical integrity, the right not to be the object of bullying or cruel treatment, inhuman or degrading treatment, the right to equal protection from the law and freedom from discrimination based on gender and others. As we can see, the origins of gender inequality were determined primarily by cultural and religious factors, as well as the peculiarities of the legal system in different countries. As a result, domestic violence has been recognized for granted almost all over the world for a long time and for a long time, and in some sources of social norms it was even recorded in legislative forms.Violence against women and domestic violence can no longer be considered a private matter, and that States must take a firm stand and take measures to prevent violence, protect victims and punish perpetrators. This issue has become extremely relevant at the present time, when the Republic of Kazakhstan is becoming an almost full-fledged participant in global integration processes, supporting the idea of prioritizing the rights and freedoms of man and citizen. The paper provides a comparative analysis of the legislation of the United States of America, Canada, Germany, Austria and France. It is concluded that the positive foreign experience in the field of prevention of domestic violence, which can be applied in Kazakhstan, should be: the construction and creation of social institutions whose activities are aimed at preventing domestic violence (USA) - the need to introduce a system of support for social initiatives in the field of prevention of domestic violence (USA) - the creation on the basis of the National Academy of Sciences of the Republic Kazakhstan Institute for Research on Domestic Violence (Canada); grouping of measures aimed at preventing domestic violence by group affiliation (France); the need to assess the effectiveness of measures applied in the field of prevention of domestic violence (Germany).
O POTENCIAL DA ARQUEOLOGIA PARA ATUAR NA IDENTIFICAÇÃO HISTÓRICA E NA VALORIZAÇÃO DOS BENS SOCIOCULTURAIS
Authors: Barboza Vania Maria 
Published: October 2024

O rio Uruguai, marco divisor dos estados sulinos Rio Grande do Sul e Santa Catarina, abriga sítios arqueológicos com grande quantidade de materiais líticos e cerâmicos, carvões e vestígios que evidenciam a presença de populações indígenas em períodos que antecedem a chegada do homem ao continente americano. Esta revisão de literatura busca apresentar o processo de povoamento do sul do Brasil e, a partir dos estudos arqueológicos, contextualizar a trajetória dos primeiros grupos humanos, a ocupação indígena, principalmente na região do rio Uruguai, além de tratar da importância da educação patrimonial como ferramenta que oportuniza o resgate da identidade, da consciência histórica e social e valorização dos bens socioculturais. O patrimônio cultural de um povo, bem como suas diversas formas de manifestações, são reflexos da sua diversidade cultural, fator que convida a refletir a formação histórica, modos de vida, valores e atributos que distinguem os diferentes grupos e populações.
ENTRE CORES E SIGNIFICADOS: OS TAPETES DEVOCIONAIS DA SEMANA SANTA EM OURO PRETO COMO EXPRESSÃO DE PATRIMÔNIO CULTURAL IMATERIAL, HISTÓRIA E TURISMO
Authors: Araújo Nilson Ricardo , Dos Santos Alves Kerley , De Souza Braga Solano 
Published: October 2024

O presente artigo discorre sobre os tapetes devocionais da Semana Santa de Ouro Preto, Minas Gerais, como expressão de patrimônio cultural imaterial, história e turismo, destacando sua origem no século XVIII e sua relevância como elemento cultural, religioso e artístico. O objetivo foi analisar a representação visual dos tapetes devocionais enquanto elementos estéticos e simbólicos com ênfase nos materiais e significados a eles atribuídos pelos moradores da cidade, participantes da pesquisa. Para isso, adota uma abordagem qualitativa e descritiva, utilizando métodos como pesquisa bibliográfica, registro fotográfico, observação participante e entrevista. A discussão propôs compreender o papel da representação visual, especialmente no contexto dos tapetes devocionais, como um meio de preservar, promover, valorizar e transmitir essa herança cultural. Como resultado, percebeu-se que os valores, os significados e a percepção do patrimônio cultural dos tapetes devocionais contribui para a construção de narrativas culturais que, neste contexto, promovem o reconhecimento de sua importância histórica, patrimonial e turística.
Accesibilidad al Sistema Nacional de Salud: equidad y listas de espera, un estudio observacional
Authors: Martín-Fernández Jesús , Rodríguez-Cabrera Francisco 
Published: October 2024

Objetivo: evaluar la asociación entre el nivel socioeconómico y las dificultades de acceso a la atención sanitaria, analizando el impacto de las listas de espera en una muestra representativa de la población española y determinando la variabilidad entre diferentes grupos de enfermedades.

Métodos: estudio observacional transversal a partir de la Encuesta Europea de Salud en España (EESE) de 2020. La variable dependiente fue la falta autorreportada de atención médica a causa de la lista de espera. Las variables independientes incluyeron datos demográficos, sociales y clínicos. Se hicieron análisis descriptivos contemplando los pesos muestrales de cada individuo, así como modelos lineales generalizados mediante la comparación de los criterios de información de Akaike y Bayes.

Resultados: nuestro estudio incorpora 19.825 personas. Un 14% declaró una falta de atención médica en los últimos 12 meses. La pertenencia a un grupo social bajo se asoció con un aumento del 18,7% (intervalo de confianza [IC] 95%: 2,6-37,4%) del riesgo de no recibir atención médica a causa de las listas de espera. La enfermedad osteoarticular se asoció con un incremento del riesgo del 115,6% (IC 95%: 77,8-161,4%), la alteración de la salud mental con un riesgo adicional del 58,0% (IC 95%: 42,2-75,7%) y la respiratoria con un riesgo adicional del 54,8% (IC 95%: 14,7-108,9%).

Conclusión: las listas de espera suponen una inequidad en el acceso a la atención médica para los grupos de menor estatus socioeconómico. Además, existen grupos de enfermedades como las osteoarticulares, de salud mental y respiratorias, que presentan mayores dificultades para acceder a dicha atención por las listas de espera.

Palabras clave: listas de espera, clase social, accesibilidad a los servicios de salud, encuestas de atención de la salud.