bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct effects of tubulin isotype mutations on neurite growth inCaenorhabditis elegans
Authors: Zheng Chaogu , Diaz-Cuadros Margarete , Nguyen Ken C.Q. , Hall David H. , Chalfie Martin 
Published: April 2017

AbstractTubulins, the building block of microtubules (MTs), play a critical role in both supporting and regulating neurite growth. Eukaryotic genomes contain multiple tubulin isotypes, and their missense mutations cause a range of neurodevelopmental defects. Using theC. eleganstouch receptor neurons, we analyzed the effects of 67 tubulin missense mutations on neurite growth. Three types of mutations emerged: 1) loss-of-function mutations, which cause mild defects in neurite growth; 2) antimorphic mutations, which map to the GTP binding site and intradimer and interdimer interfaces, significantly reduce MT stability, and cause severe neurite growth defects; and 3) neomorphic mutations, which map to the exterior surface, increase MT stability, and cause ectopic neurite growth. Structure-function analysis reveals a causal relationship between tubulin structure and MT stability. This stability affects neuronal morphogenesis. As part of this analysis, we engineered several disease-associated human tubulin mutations intoC. elegansgenes and examined their impact on neuronal development at the cellular level. We also discovered an α-tubulin (TBA-7) that appears to destabilize MTs. Loss of TBA-7 led to the formation of hyperstable MTs and the generation of ectopic neurites; the lack of potential sites for polyamination and polyglutamination on TBA-7 may be responsible for this destabilization.Table of Content (TOC) Highlight SummaryDifferent tubulin isotypes perform different functions in the regulation of MT structure and neurite growth, and missense mutations of tubulin genes have three types of distinct effects on MT stability and neurite growth. One α-tubulin isotype appears to induce relative instability due to the lack of potential post-translational modification sites.
High-speed data provision via mobile networks in Latin America and the Caribbean
Authors: Curwen Peter , Whalley Jason 
Published: April 2017

Purpose
The purpose of this paper is to examine in a fully up-to-date manner the position in respect of the licensing and launch of long-term evolution (LTE) (4G) in a region that attracts relatively little attention in academic work and the media. The purpose is also to examine the role of incumbency and to assess to what extent the licensing of LTE can make a difference to the structure of mobile markets in the region.

Design/methodology/approach
The first step has been to compile extensive databases with respect to the licensing and launch of high-speed networks in the region, arranged so as to emphasize the position of the dominant incumbents. A distinction is drawn between the larger, mainly Latin American, countries and the smaller, mainly Caribbean, islands. There is a discussion of new entry and its potential to disrupt incumbents.

Findings
The position of dominance held by two operators – América Móvil and Telefonica in the larger countries and by Digicel and Cable & Wireless Communications (Liberty Global) in the islands – is brought to the fore, and the analysis demonstrates that this is unlikely to be more than marginally affected by regulatory attempts to restructure markets by, for example, fostering new entry.

Research limitations/implications
This is necessarily an overview paper as more than 50 countries/islands are covered, so detailed individual country studies are precluded.

Practical implications
The way forward, such as it is, can only be illuminated by first clarifying the current state of play.

Originality/value
The databases that underpin the analysis are author-compiled and entirely original.
The complexity of the antecedents influencing accountability in organisations
Authors: Pearson Hayley , Sutherland Margaret 
Published: April 2017

Purpose
Business, society and academic literature all show an increase in the demand for greater accountability. Although accountability is deemed to be central to performance in the workplace, it is an ever-expanding, complex and elusive phenomenon. There is very little empirical research in human resource literature on accountability’s wide-ranging antecedents and how they are best implemented. This paper aims to set out to identify which factors have the greatest influence when holding an individual to account.

Design/methodology/approach
Qualitative, exploratory research methods were adopted. Twenty semi-structured, in-depth interviews were conducted with CEO’s, executives, human resource experts, senior managers and consultants in eight industries in South Africa. The data were analysed by thematic content analysis.

Findings
The findings identified five dominant antecedents that are required to effectively hold an individual to account for their performance. These are the culture and leadership of the organisation, the systems in the organisation, the values and recruitment means of the individual and the clarity of role. For each of these factors, the key management mechanisms were identified.

Research limitations/implications
The study was done in one country (South Africa) and only with senior executives.

Practical/implications
A “System of Accountability” model was developed depicting the interdependence of the factors and conceptualising a process that can be followed for human resource professionals and senior management to develop a culture of accountability.

Originality/value
There is a dearth of literature and empirical research on how to implement a combination of systems to ensure accountability in the workplace. This research offers some solutions to that gap in the literature.
Inter-organizational cooperation and organizational innovativeness. A comparative study
Authors: Pouwels Ivan , Koster Ferry 
Published: April 2017

PurposeThis paper aims at integrating previous studies investigating the relationship between inter-organizational cooperation and organizational innovation. Earlier research provides mixed results regarding this relationship. In this paper, it is argued that this may be because of an empirical bias in these studies, as they tend to focus on one sector, one type of innovation or one country. Using a cross-national comparative data set enables to account for these potential biases and establish the relationship between inter-organizational cooperation and organizational innovation.Design/methodology/approachThe study examines the effect of inter-organizational cooperation on product, process, organizational and market innovation, using data from 32 European countries and 6 different sectors (n= 27,019). The data are analyzed using logistic regression analysis.FindingsThe analysis shows that there is a positive relationship between inter-organizational cooperation and organizational innovation, even when controlled for common innovation variables including general characteristics, organizational structure, organizational culture, HR strategies, networking interaction and external knowledge acquisition.Originality/valueIn contrast to most prior studies that rely on data from one sector, one country and one innovation type, this study examines the relationship between inter-organizational cooperation and organizational innovativeness by taking into account multiple sectors, countries and types of innovation. This intends to generate more robust results regarding the link between inter-organizational cooperation and organizational innovativeness.
Hospital admissions for HIV-infected prisoners in Italy
Authors: Pontali Emanuele , Ranieri Roberto , Rastrelli Elena , Iannece Maria Donata , Ialungo Anna Maria , Dell’Isola Serena , Liberti Alfonso , Rosario Pietro , Casati Rodolfo , Starnini Giulio , Babudieri Sergio 
Published: April 2017

Purpose
The purpose of this paper is to give a description of the clinical conditions and patient demographics of inpatient admissions of human immunodeficiency virus (HIV)-infected inmates in three hospital wards that provide hospital care for inmates in Italy.

Design/methodology/approach
This is a retrospective review of hospital medical admissions of patients living with HIV from January 1 to December 31, 2014, in three Italian referral centers for hospitalization of inmates.

Findings
A total of 85 admissions for 85 different HIV-infected inmates occurred in 2014 in the three centers participating to the study. Most patients (54.1 percent) were co-infected with hepatitis C. Discharge diagnosis largely varied ranging from common HIV-related co-morbidities to completely independent diagnosis. The most commonly observed discharge diagnoses were chronic hepatitis C, liver cirrhosis, opiate dependence and thrombocytopenia.

Originality/value
Discharge diagnosis between HIV-infected inmates and HIV-infected patients in freedom are strikingly and significantly different. A large number of hospitalized HIV-infected inmates were affected by chronic viral hepatitis and liver cirrhosis; this is probably a direct consequence of the high prevalence of HCV and/or HBV co-infections in the inmate population in Italy. In addition, a significantly lower proportion of cancer diagnosis was observed among inmates; this is possibly justified by the fact that in our Italian settings when HIV infection is at advanced stages or if cancer treatment is started those affected are released from prison and can continue their diagnostic and treatment follow-up in freedom.
Explaining small-retailer patronage through social capital theory
Authors: Yildiz Hélène , Heitz-Spahn Sandrine , Belaud Lydie 
Published: April 2017

Purpose
The purpose of this paper is to understand why people shop at small retailers in their community. The authors investigate the influence of consumers’ civic commitment, measured at behavioural and perceptual levels, on small-retailer patronage (SRP).

Design/methodology/approach
Data from 984 respondents represent four French cities that host common town-centre shopping streets and large out-of-town retail parks. A structural equation model applied to the theoretical framework tests the relationships between civic behavioural commitment (CBC), civic perceptual commitment (CPC) and declared SRP.

Findings
The more an individual consumer exhibits civic behavioural commitment (CBC) to his/her community, the greater his/her small-retailer patronage (SRP). Furthermore, consumers who express strong civic perceptual commitment (CPC) prefer to patronise small retailers. Results show that CPC has a stronger impact on SRP than CBC does.

Practical implications
If the CPC has stronger effects on SRP than CBC does, town managers can catch people’s attention by communicating civic commitment to enhance CPC. Solidarity could be developed through large-scale social projects to send a strong signal to consumers regarding retailers’ commitment in the community. Finally, the study highlights the role businesses, retailers and consumers play in building communities. Partnerships across all local stakeholders should be built.

Originality/value
This paper is the first to define civic behavioural commitment within consumers’ life place based on social capital theory. Moreover, it offers a new framework for understanding perception of commitment within a community, and its impact on SRP. This measurement scale allows more efficient capturing of civic commitment to communities.
Co-innovation platform affordances
Authors: Abhari Kaveh , Davidson Elizabeth J. , Xiao Bo 
Published: April 2017

Purpose
The importance of co-innovation platforms has been well established, but a valid and reliable instrument to measure the affordances of these platforms for co-innovation behavior has not yet been reported in the literature. A robust, validated instrument to measure co-innovation platform affordances (PAs) will facilitate the conduct of studies across different platforms and contribute to enhanced understanding of co-innovation behaviors, outcomes, and platform design. The purpose of this paper is to conceptualize co-innovation PAs, develop a reliable measurement instrument capturing critical facets of co-innovation, namely ideation, collaboration, and communication, and validate the instrument.

Design/methodology/approach
The construct of PAs was conceptualized based on the findings from two case studies of co-innovation networks and the key characteristics of social mediating technology affordances. The measurement items newly developed via a case study underwent a two-round exploratory analysis to ensure face validity and content validity. The resulting instrument was subjected to a pilot study and a field study to establish the necessary reliability and validity.

Findings
The findings of the study reveal that co-innovation PAs have three distinctive components, namely ideation, collaboration, and communication. Furthermore, the results of the study suggest that PAs are most appropriately operationalized as a second-order construct comprising all three components. The empirical results from the field study show a high degree of confidence in both translation validity and criterion-related validity.

Originality/value
Drawing from co-innovation and affordances literature, this study develops and validates a general instrument to measure co-innovation PAs. The result is a reliable and parsimonious instrument with 12 items. The authors believe that the instrument can contribute significantly to future empirical investigations of co-innovation behavior on virtual platforms.
Collaborative practices with suppliers in Indian manufacturing multinationals
Authors: Hudnurkar Manoj , Rathod Urvashi 
Published: April 2017

Purpose
The aim of this research was to study collaborative practices with suppliers in multinational manufacturing companies operating in India and to develop a framework for collaboration with suppliers.

Design/methodology/approach
This study adopted a four-step mixed-methods approach that included qualitative and quantitative methods. Qualitative technique was used to explore the factors and develop a balanced scorecard-based (BSC – balanced scorecard) framework using them. Quantitative technique was used to validate the framework statistically and also by using fuzzy analytical hierarchy process using perception-based ranks given by practitioners.

Findings
The exploratory research resulted in 26 antecedents for collaboration with suppliers in supply chains. Out of these 26, only 19 were considered based on importance given by practitioners. Further, the identified antecedents were classified and mapped based on the perspectives of the BSC. The extended BSC adds business environment and partnership perspectives to existing BSC framework. Some of the important factors identified under these perspectives were transparency of transactions, long-term commitment and trust. The customer perspective was given the utmost importance by the practitioners.

Research limitations/implications
There are certain issues that may limit the completeness of the work in a global context. The number of organizations (21) and respondents (45) may also be insufficient to convey the complete knowledge embedded in the practice of the field.

Originality/value
The study provides practical insights about the factors affecting collaboration with suppliers. A BSC-based framework for collaboration with suppliers was also developed along with the associated importance of each perspective and factors under each perspective, which can prove to be of great value to academics and practitioners involved in relationship with suppliers in supply chain.
Peer support services: state of the workforce-state of the field in the USA
Authors: Rogers E. Sally 
Published: April 2017

Purpose
Peer support and other consumer-provided services have burgeoned within the USA during the past 30 years and are now a central component of mental health services nationally. However, their growth has been uneven and somewhat dependent on state initiatives, policies, and funding. Recent programs have matured along myriad paths, resulting in a variety of program typologies, service structures, and funding streams, but with common values, missions, and principles. The paper aims to discuss these issues.

Design/methodology/approach
The landscape of peer specialist services in the USA, as well as innovations afoot, is reviewed. The empirical information that speaks to the efficacy of peer support and the need to better understand the mechanisms by which it is effective is described.

Findings
Although peer support has grown exponentially across the USA, its growth has been uneven. Evidence suggests that peer specialists experience role ambiguity within many existing programs and systems. Though the empirical evidence for peer services has grown, research has been most favorable for manualized, group interventions. There is still a need to better understand how individual peer support is beneficial and effective, and how individual peer support can best be utilized to promote the best outcomes for those served.

Research limitations/implications
In order for the workforce of peer support specialists to continue to grow and for services to be responsive and innovative, we need to better understand the mechanisms by which peer support is beneficial and how it can be structured and delivered to promote the best outcomes for those served. The “core conditions” of helping relationships promulgated decades ago by Rogers along with research on self-disclosure may be useful frameworks for understanding and researching the effectiveness of peer support.

Practical implications
More research is needed to better understand the effectiveness of peer support services and how best to insure that they are well-integrated into the mental health programs and systems in which they serve.

Originality/value
There is a need to understand why peer support is effective and how best to sustain peer specialists in their roles within the mental health system.
Effect of build orientation on the mechanical reliability of 3D printed ABS
Authors: Keleş Özgür , Blevins Caleb Wayne , Bowman Keith J. 
Published: April 2017

PurposeIncreasing use of 3D printing techniques to manufacture consumer products and open-source designs raises the question of “What is the mechanical reliability of 3D printed parts?” Therefore, the purpose of this paper is to investigate the impacts of build orientation on the mechanical reliability of acrylonitrile butadiene styrene (ABS) produced using 3D printing.Design/methodology/approachTensile tests on ABS specimens were performed with and without a hole in the center, which were produced by fused deposition modeling (FDM). Seven sets of approximately 30 specimens were printed in XY, XZ and C+45 orientations to obtain reliable fracture statistics. Weibull analysis was performed to quantify the variation in the tensile strength.FindingsThe Weibull analysis showed that the reliability of FDM produced ABS can be as low as advanced ceramics. Weibull moduli of specimens without a hole were between 26 and 69, and specimens with a hole had Weibull moduli between 30 and 41. P-type deviations from the Weibull statistics were observed. The XZ orientation resulted in the highest average fracture strength for specimens with and without a hole, and C+45 orientation resulted in the lowest strength.Practical implicationsAs the Weibull distribution relates the applied stress to probability of failure, the Weibull analysis provides a practical design criterion to achieve specific reliability levels for additively manufactured parts.Originality/valueThis study, for the first time, provides Weibull statistics for FDM-produced ABS parts, which can be used to predict mechanical reliability.
An improved lattice structure design optimization framework considering additive manufacturing constraints
Authors: Gorguluarslan Recep M. , Gandhi Umesh N. , Song Yuyang , Choi Seung-Kyum 
Published: April 2017

Purpose
Methods to optimize lattice structure design, such as ground structure optimization, have been shown to be useful when generating efficient design concepts with complex truss-like cellular structures. Unfortunately, designs suggested by lattice structure optimization methods are often infeasible because the obtained cross-sectional parameter values cannot be fabricated by additive manufacturing (AM) processes, and it is often very difficult to transform a design proposal into one that can be additively designed. This paper aims to propose an improved, two-phase lattice structure optimization framework that considers manufacturing constraints for the AM process.

Design/methodology/approach
The proposed framework uses a conventional ground structure optimization method in the first phase. In the second phase, the results from the ground structure optimization are modified according to the pre-determined manufacturing constraints using a second optimization procedure. To decrease the computational cost of the optimization process, an efficient gradient-based optimization algorithm, namely, the method of feasible directions (MFDs), is integrated into this framework. The developed framework is applied to three different design examples. The efficacy of the framework is compared to that of existing lattice structure optimization methods.

Findings
The proposed optimization framework provided designs more efficiently and with better performance than the existing optimization methods.

Practical implications
The proposed framework can be used effectively for optimizing complex lattice-based structures.

Originality/value
An improved optimization framework that efficiently considers the AM constraints was reported for the design of lattice-based structures.
Agoge: an information literacy game for transfer students
Authors: Kearns Andrew , Kirsch Breanne A. , Cononie Virginia 
Published: April 2017

Purpose
This paper aims to describe a successful outreach to transfer students through an interactive information literacy game. While the main purpose of the game is to introduce students to research and university library resources, it also allows for an analysis of incoming students’ information literacy skills.

Design/methodology/approach
This case study outlines the evolution of the game from a test-like tutorial administered through the Blackboard course management system to an interactive game in two iterations, describing the game in relation to game design and best practices and discussing how the artwork for the game was created. An analysis of data from student answers to the game questions over time shows what librarians have learned about the information literacy skills of incoming transfer students. Finally, student feedback about the game collected through a survey is presented along with ideas for future modifications.

Findings
This paper provides insights into the design and creation process of an interactive information literacy game and a model for how similar games can help librarians assess students’ information literacy skills.

Practical implications
Transfer students are hard to reach as a group at many institutions. An interactive game targeted to transfers during the admissions process is a potentially effective way to reach out to them.

Originality/value
This paper brings together two important issues in the library literature: how to reach out to transfer students and educational library games. Librarians involved with these issues will benefit from the paper’s insights and practical advice.