bluuebunny/crossref_metadata_2025_split huggingface dataset:
On a New Cyclic Symmetry Formulation Accounting for Boundaries Undergoing Nonlinear Forces
Authors: Quaegebeur Samuel , Thouverez Fabrice 
Published: September 2024

Abstract
Although cyclic symmetry theory was initially developed for linear structures, the introduction of nonlinear forces on internal nodes of the fundamental sector does not affect the methodology. Nevertheless, the method is ill-suited when nonlinear forces are applied at the cyclic boundary. The purpose of this paper is to provide a complement to this theory and to propose a cyclic symmetry formulation for structures undergoing nonlinear forces at their cyclic boundary. A complete nonlinear cyclic formulation for such systems is derived in this work. The advantages of such an approach lie in the reduction of computational costs using the cyclic symmetry properties. The methodology is employed to characterize the dynamics of several mechanical systems. First, it is validated on simplified models of a cyclic system. Two nonlinearities are considered: a one-dimensional friction contact interface and a cubic nonlinearity. Both cases exhibit very different dynamics behaviors; yet, the results obtained with the new strategy are shown to be very accurate. Once the approach is validated, it is employed on an industrial finite element model of turbine bladed disk featuring contact interfaces between the blades' shrouds. The capability of the method to handle large systems is thus demonstrated. For all cases, periodic excitation are applied following either a traveling or standing wave shape for different engines orders.
Development of Indoor CO2 Monitoring System with an Integrated Fixed Sensor and a Mobile Measuring Robot
Authors: Tamura Shuichi , Kato Ouki , Shirayama Susumu 
Published: September 2024

Abstract
This paper proposes an advanced system for optimizing indoor environmental quality (IEQ) in office environments that integrates fixed sensors with a mobile measuring robot (MMR). A demand-based measurement strategy that uses human detection and predictive analytics via machine learning is used to enhance data collection accuracy and efficiency. The system incorporates voice notifications to prompt occupants to perform actions that improve IEQ. The MMR’s operational capabilities and coordination with fixed sensors allow the system to achieve high precision and efficiency in office environments. The system’s effectiveness is validated through empirical studies (two preliminary experiments and two main experiments) in real office settings. The first preliminary experiment identified measurement blind spots and the second preliminary experiment tested the equivalence of environmental measurements between the MMR and fixed sensors. The first main experiment showed the system’s human detection function for efficient and precise environmental measurement and the voice notification function for prompting occupants to perform actions that improve IEQ. The second main experiment showed the system’s predictive accuracy in forecasting CO2 levels using neural network models. The main experiments demonstrate that the system can effectively guide MMR operations, reduce measurement times, and accurately predict environmental changes. The proposed system is a comprehensive solution for IEQ enhancement in office buildings.
A model for polyomavirus helicase activity derived in part from the AlphaFold2 structure of SV40 T-antigen
Authors: Shin Jong , Meinke Gretchen , Bohm Alex A. , Bullock Peter A. 
Published: September 2024

ABSTRACT

The mechanism used by polyomavirus and other viral SF3 helicases to unwind DNA at replication forks remains unknown. Using AlphaFold2, we have determined the structure of a representative SF3 helicase, the SV40 T-antigen (T-ag). This model has been analyzed in terms of the features of T-ag required for helicase activity, particularly the proximity of the T-ag origin binding domain (OBD) to the replication fork and the distribution of basic residues on the surface of the OBD that are known to play roles in DNA unwinding. These and related studies provide additional evidence that the T-ag OBDs have a role in the unwinding of DNA at the replication fork. Nuclear magnetic resonance and modeling experiments also indicate that protonated histidines on the surface of the T-ag OBD play an important role in the unwinding process, and additional modeling studies indicate that protonated histidines are essential in other SF3 and SF6 helicases. Finally, a model for T-ag’s helicase activity is presented, which is a variant of the “rope climber.” According to this model, the hands are the N-terminal OBD domains that interact with the replication fork, while the C-terminal helicase domains contain the feet that bind to single-stranded DNA.

IMPORTANCE
Enzymes termed helicases are essential for the replication of DNA tumor viruses. Unfortunately, much remains to be determined about this class of enzymes, including their structures and the mechanism(s) they employ to unwind DNA. Herein, we present the full-length structure of a model helicase encoded by a DNA tumor virus. Moreover, this AI-based structure has been analyzed in terms of its basic functional properties, such as the orientation of the helicase at replication forks and the relative locations of the amino acid residues that are critical for helicase activity. Obtaining this information is important because it permits proposals regarding how DNA is routed through these model helicases. Also presented is structural evidence that the conclusions drawn from our detailed analyses of one model helicase, encoded by one class of tumor viruses, are likely to apply to other viral and eukaryotic helicases.
Impact of family doctor system on diabetic patients with distinct service utilisation patterns: a difference-in-differences analysis based on group-based trajectory modelling
Authors: Liu Xinyi , Zhang Luying , Fan Xianqun , Chen Wen 
Published: September 2024

IntroductionThis study examines the impact of China’s family doctor system (FDS) on healthcare utilisation and costs among diabetic patients with distinct long-term service utilisation patterns.MethodsConducted in City A, eastern China, this retrospective cohort study used data from the Health Information System and Health Insurance Claim Databases, covering diabetic patients from 1 January 2014 to 31 December 2019.Patients were categorised into service utilisation trajectories based on quarterly outpatient visits to community health centres (CHCs) and secondary/tertiary hospitals from 2014 to 2017 using group-based trajectory models. Propensity score matching within each trajectory group matched FDS-enrolled patients (intervention) with non-enrolled patients (control). Difference-in-differences analysis compared outcomes between groups, with a SUEST test for cross-model comparison. Outcomes included outpatient visits indicator, costs indicator and out-of-pocket (OOP) expenses.ResultsAmong 17 232 diabetic patients (55.21% female, mean age 62.85 years), 13 094 were enrolled in the FDS (intervention group) and 4138 were not (control group). Patients were classified into four trajectory groups based on service utilisation from 2014 to 2017: (1) low overall outpatient utilisation, (2) high CHC visits, (3) high secondary/tertiary hospital visits and (4) high overall outpatient utilisation. After enrolled in FDS From 2018 to 2019, the group with high secondary/tertiary hospital visits saw a 6.265 increase in CHC visits (225.4% cost increase) and a 3.345 decrease in hospital visits (55.5% cost reduction). The high overall utilisation group experienced a 4.642 increase in CHC visits (109.5% cost increase) and a 1.493 decrease in hospital visits. OOP expenses were significantly reduced across all groups.ConclusionThe FDS in China significantly increases primary care utilisation and cost, while reducing hospital visits and costs among diabetic patients, particularly among patients with historically high hospital usage. Policymakers should focus on enhancing the FDS to further encourage primary care usage and improve chronic disease management.
Cellular pattern and orbital fat involvement are possible risk factors for the failure of corticosteroids in patients with pure idiopathic orbital inflammation syndrome: lessons from the French prospectiveSIOIcohort study (part II)
Authors: La Rosa Ambre , Groh Matthieu , Martin Antoine , Tran Ba Stéphane , Cucherousset Nahla , Mouriaux Frédéric , Sedira Neila , Héron Emmanuel , Galatoire Olivier , Saadoun David , Abbas Aïcha , Bassirou Mboup , Vicaut Eric , Dhote Robin , Abad Sebastien 
Published: September 2024

PurposeTo better characterise the effects of corticosteroids on the course of pure idiopathic orbital inflammation syndrome (pIOIS).MethodsThis was a national, multicentre, prospective, non-interventional cohort study (SIOI). Among the 35 patients with histologically proven orbital inflammation who had previously been studied for their IgG4 immunostaining status, we selected those with a negative IgG4 status (ie, pIOIS) who received corticosteroids as single first-line treatment. Clinical, morphological and pathological findings at diagnosis and during follow-up from treatment initiation to study completion were analysed. Patients were assessed for their response to prednisone after the 24-month prospective phase in terms of remission (≤10 mg/d) or failure (>10 mg/d). Daily standard doses of prednisone (DSDP) were calculated at different time-points and compared between response groups.ResultsOf the 17 patients with pIOIS included in the final analysis, two-thirds received corticosteroids only. DSDP (mg/kg-day) were significantly higher at the time of failure in eight patients (47%) than in nine (53%) remitting at M24 (0.16 vs 0.045; p: 0.03). Notably, patients with pIOIS with a cellular pattern or orbital fat involvement tended to receive higher daily corticosteroid doses in the event of failure than remission (0.16 vs 0.045 and 0.12 vs 0.042, respectively). During treatment, maximal DSDP was 0.52 in failed patients.ConclusionThe highest corticosteroid doses were insufficient to prevent failure in patients with pIOIS, particularly in those with a cellular pattern or orbital fat involvement. Large-scale interventional studies are now necessary to clarify prognostic factors and optimise corticosteroid management in patients with pIOIS.
Are perceived barriers to physical activity related to depression, anxiety and stress among adolescents? The EHDLA study
Authors: de Camargo Edina Maria , Chen Sitong , López-Bueno Rubén , Mesas Arthur Eumann , Bizzozero-Peroni Bruno , Martín-Calvo Nerea , Jiménez-López Estela , López-Gil José Francisco 
Published: September 2024

ObjectiveThe aim of this study was twofold: first, to examine the association between perceived barriers to physical activity (PA) practice and depression, anxiety and stress in a sample of Spanish adolescents; and second, to determine which barriers are specifically associated with depression, anxiety and stress.MethodsThis cross-sectional study was conducted with 765 adolescents aged 12–17 (55.6% girls) in theValle of Ricote, Murcia, Spain. Depression, anxiety and stress symptoms were assessed using the Depression, Anxiety and Stress Scale (DASS-21), with validated cut points employed to determine the presence of each of these mental conditions. The perception of barriers to PA was assessed using a validated questionnaire for the Spanish adolescent population.ResultsThe barrier ‘Because I feel that my physical appearance is worse than that of others’ was related to a higher likelihood of having depression (OR=2.41; 95% CI 1.35 to 4.28; p=0.003), anxiety (OR=2.65; 95% CI 1.51 to 4.71; p=0.001) and stress (OR=2.82; 95% CI 1.59 to 5.07; p<0.001). Similarly, the barrier ‘Because nobody encourages me to engage in physical activity’ was related to a higher likelihood of having depression (OR=1.92; 95% CI 1.08 to 3.43; p=0.026), anxiety (OR=1.97; 95% CI 1.11 to 3.50; p=0.021) and stress (OR=1.99; 95% CI 1.12 to 3.59; p=0.021).ConclusionPerceived barriers to PA related to physical appearance and social support seem to be associated with a greater likelihood of depression, anxiety and stress among Spanish adolescents.
Total reaction cross section of light stable and exotic nuclei on lead at energies around the Coulomb barrier
Authors: Mohr Peter 
Published: September 2024

AbstractThe present review studies total reaction cross sections from elastic scattering angular distributions of light stable and exotic projectiles ($$2 \le Z_P \le 10$$

2
≤

Z
P

≤
10

, $$4 \le A_P \le 24$$

4
≤

A
P

≤
24

) on 208Pb at energies around the Coulomb barrier. From the overall about 200 data it is found that the widely accepted simple grouping of the derived reduced cross sections into three categories—tightly bound, weakly bound, and exotic halo projectiles—is too simplistic and does not fully reflect the range of the experimental data. Furthermore, the energy dependence of the reduced cross sections shows unexpected properties which were hitherto only sparsely considered.
At the Interface of Tumor-Associated Macrophages and Fibroblasts: Immune-Suppressive Networks and Emerging Exploitable Targets
Authors: Timperi Eleonora , Croizer Hugo , Khantakova Darya , Rana Mhaidly , Molgora Martina , Guerriero Jennifer L. , Mechta-Grigoriou Fatima , Romano Emanuela 
Published: September 2024

Abstract
Tumor-associated macrophages (TAM) constitute a prominent immune cell population within various solid cancers, playing a pivotal role in disease progression. Their increased numbers and frequencies often strongly correlate with resistance to therapy and reduced overall survival rates. Within the complex ecosystem of the tumor microenvironment (TME), activated cancer-associated fibroblasts (CAF) are expanded and contribute significantly to tumor growth and metastasis and chemotherapy or immunotherapy resistance. CAFs exert a critical influence on TAM phenotypes and functions by orchestrating the reprogramming of tissue-infiltrating monocytes, thereby modulating their survival and differentiation. This reciprocal interaction between TAMs and CAFs forms a crucial axis in fostering a suppressive crosstalk within the TME, mediated by a diverse array of signals exchanged between these cell types. Recent advancements in single-cell RNA sequencing technologies and spatial transcriptomics have enhanced our comprehension of the signaling dynamics at the interface between TAMs and CAFs, including their spatial distribution within the tissue. In this review, we delve into the latest discoveries elucidating the biology of TAM and CAF crosstalk. We examine the complexity of TAM–CAF and CAF–TAM interactions within the TME of solid cancers, with particular focus on ligand–receptor interactions and clinically significant targets for novel therapeutic strategies.
Integrated Imaging Probe and Bispecific Antibody Development Enables In Vivo Targeting of Glypican-3–Expressing Hepatocellular Carcinoma
Authors: Habibollahi Peiman , Gurevich Alexey , Hui James Z. , Weinfurtner Kelly , McClung George , Adler Justin , Soulen Michael C. , Kaplan David E. , Nadolski Gregory J. , Hunt Stephen J. , Tsourkas Andrew , Gade Terence P. 
Published: September 2024

Abstract
Glypican-3 (GPC3) is a proteoglycan with high sensitivity and specificity for hepatocellular carcinoma (HCC). We describe the integrated development and validation of a GPC3-targeting optical imaging probe and T cell–redirecting antibody (TRAB) as a theranostic strategy for the detection and treatment of HCC. A novel TRAB targeting GPC3 on HCC tumor cells and the CD3 T-cell receptor as well as a distinct GPC3-specific optical imaging probe were developed from a short peptide. The efficacy of GPC3/CD3 TRAB was evaluated in vitro using IFNγ release and calcein-AM assays. Patient-derived xenografts were used to assess the in vivo efficacy of GPC3/CD3 TRAB and the GPC3 imaging probe for the detection of GPC3+ HCC. GPC3/CD3 TRAB caused a dose-dependent escalation in IFNγ release from inactive peripheral blood T cells (P = 0.001) and higher tumor-cell lysis (P = 0.01) compared with controls in vitro. Intratumorally injected GPC3/CD3 TRAB resulted in significant prolongation of tumor doubling time in the GPC3+ tumors, with an associated reduction of tumor fluorescent signal from the HiLyte 488–conjugated GPC3-specific peptide on optical imaging. These data demonstrate that HCC cell targeting using a GPC3/CD3 TRAB derived from a small peptide enabled effective T-cell activation and induction of a cytotoxic response toward GPC3+ HCC tumor cells both in vitro and in vivo. GPC3-specific optical imaging enabled the detection of the GPC3+ HCC cells and noninvasive monitoring of tumor response to adoptive immunotherapy. The integrated development of a targeted therapeutic and molecular imaging probe provides a promising paradigm for the development of cancer theranostics.
Looking Beyond Checkpoint Inhibitor Monotherapy: Uncovering New Frontiers for Pancreatic Cancer Immunotherapy
Authors: Giurini Eileena F. , Ralph Oliver , Pappas Sam G. , Gupta Kajal H. 
Published: September 2024

Abstract
Pancreatic ductal adenocarcinoma (PDAC) stands out as one of the most aggressive and challenging tumors, characterized by a bleak prognosis with a mere 11% survival rate over 5 years in the United States. Its formidable nature is primarily attributed to its highly aggressive behavior and poor response to existing therapies. PDAC, being notably resistant to immune interventions, presents a significant obstacle in treatment strategies. While immune checkpoint inhibitor therapies have revolutionized outcomes for various cancers, their efficacy in PDAC remains exceedingly low, benefiting less than 1% of patients. The consistent failure of these therapies in PDAC has prompted intensive investigation, particularly at the preclinical level, to unravel the intricate mechanisms of resistance inherent in this cancer type. This pursuit aims to pave the way for the development of novel immunotherapeutic strategies tailored to the distinct characteristics of PDAC. This review endeavors to provide a comprehensive exploration of these emerging immunotherapy approaches in PDAC, with a specific emphasis on elucidating their underlying immunological mechanisms. Additionally, it sheds light on the recently identified factors driving resistance to immunotherapy and evasion of the immune system in PDAC, offering insights beyond the conventional drivers that have been extensively studied.
Placing Art Practice into the Field of Bioimaging: Testing Play as a Methodological Tool to Explore and Reflect upon Art Practice
Authors: Berry-Frith Joanne 
Published: September 2024

Abstract
Bioimaging experiments are carried out in discrete labs, and artists are rarely granted access. The author finds that they are an underused resource for artist-researchers. In this article, she demonstrates how an artist-researcher can contribute to artscience initiatives in pharmacological research by working in an advanced imaging and microscopy lab and responding innovatively to current circumstances in bioimaging. She does this by thinking about scientific and artistic interdisciplinary practice in a playful way. Informed by established play theories and practices from the literature, she has reviewed, studied, and adapted. Here she discusses research conducted at the School of Life Sciences at the University of Nottingham, where she evaluated play as an insightful concept to provoke a reaction to scientific methods.
Video as World Mandala: Nakajima Ko’s Animaker, Aniputer, and Cosmic Video
Authors: Horisaki-Christens Nina 
Published: September 2024

Abstract
Early video processing tools present a compelling perspective through which to reconsider the integrated practice of Tokyo-based early video artist Nakajima Ko. The author examines Nakajima's practice through his concepts of animation, the development of his Animaker (1979) and Aniputer (1982) the ways he sees video connected to Esoteric Buddhist thought. Returning then to his 1986 video Mt. Fuji, the author illustrates how it is representative of the hybrid analog-digital view of video that leads Nakajima to posit it as a cosmic medium circa 1986.
Archaeologies and Organologies: Towards an alternative history of early synthetic video and image processing practices 1939–1969
Authors: King Chris Jan 
Published: September 2024

Abstract
This article focuses on the early history of two related techniques deployed within artistic contexts; the distortion of pre-existing television raster images and the generation of synthetic images through the application of external signals to cathode-ray tube deflection systems. Organology and media archaeological techniques are used to begin to trace an additional technical history of these complex visual instruments.
The Adventures of MouseGirl: An Undergraduate’s Perspective on her Data Visualization Project and the Need for STEAM in American Education
Authors: Lee Hannah 
Published: September 2024

Abstract
The author’s unique arts-science research experience involving data visualizations of complex mouse brain data leads her to recognize that education in America needs to adopt the increasingly popular STEAM education movement. This is a view that many others, both students and professors, increasingly share in the light of their own successes with learning and accessibility using STEAM methods. These successes also show the importance of incorporating the arts into STEM education. In this article, the author will discuss her data visualization in the context of advocating for the importance of STEAM education and collaborations in general.
Action at a Distance: Did Physicist Thomas Young’s 1807 Lectures Inspire Some of the Earliest Examples of Abstract Art?
Authors: Lundgren Britt 
Published: September 2024

Abstract
Swedish artist Hilma af Klint is known to have been influenced by scientific developments at the turn of the twentieth century. However, many of her paintings from 1914 to 1916 exhibit similarities to diagrams published much earlier in the English polymath Thomas Young’s 1807 A Course of Lectures on Natural Philosophy and the Mechanical Arts. Key elements and themes in af Klint’s The Dove, The Swan, Parsifal, and Altarpieces series suggest Young’s Lectures may have been a major source for her work. The author explores this idea and other parallels between the lives and legacies of the visionary scientist and the abstract art pioneer.
An Image Dispute Resulting from Pareidolia?
Authors: Mäkelä Jyrki P. , Fagerlund Emmi-Lotta 
Published: September 2024

Abstract
In the 1940s Nikolai Kaario, an artist and a decorative painter, discovered seemingly old images on house walls in Turku, Finland. These findings generated considerable interest in the press. The Archeological Commission of Finland evaluated them, concluding that the images were not medieval and were made unconsciously by Kaario. Despite the Commission’s findings, the dispute did not abate. Several other people also found similar images on the walls of old houses in Turku, even after Kaario’s death. The authors review these events and suggest that they reflect the effects of pareidolia.
Scalar Wave Paintings: A New Approach to Postdigital Art
Authors: Rummler Scott 
Published: September 2024

Abstract
The author has developed a new kind of artwork that he calls the “scalar wave painting.” These works use specially prepared canvas, paint and lighting environments to create optical interference with digital cameras. The works appear white to the naked eye but emit frequencies that are similar to quantum scalar waves and take on multiple, changing hues when viewed through a digital camera. This work is of artistic interest because each photograph of the same object will look different. Therefore, it challenges perception and changes the one-to-one relationship between object and representation at the center of much of art and technology theory.