bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality improvement on half‐fin anchovy (Setipinna taty) fish sauce by Psychrobacter sp. SP‐1 fermentation
Authors: Zheng Bin , Liu Yu , He Xiaoxia , Hu Shiwei , Li Shijie , Chen Meiling , Jiang Wei 
Published: March 2017

AbstractBACKGROUNDA method of improving fish sauce quality during fermentation was investigated. Psychrobacter sp. SP‐1, a halophilic protease‐producing bacterium, was isolated from fish sauce with flavor‐enhancing properties and non‐biogenic amine‐producing activity. The performance of Psychrobacter sp. SP‐1 in Setipinna taty fish sauce fermentation was investigated further.RESULTSThe inoculation of Psychrobacter sp. SP‐1 did not significantly affect pH or NaCl concentration changes (P > 0.05), although it significantly increased total moderately halophilic microbial count, protease activity, total soluble nitrogen content and amino acid nitrogen content, and also promoted the umami taste and meaty aroma (P < 0.05). Furthermore, the inoculation of Psychrobacter sp. SP‐1 significantly decreased total volatile basic nitrogen content and biogenic amines content (P < 0.05), which were regarded as harmful compounds in foods.CONCLUSIONThe results of the present study demonstrate that Psychrobacter sp. SP‐1 can be used as a potential starter culture for improving fish sauce quality by fermentation. © 2017 Society of Chemical Industry
Long‐term MRI surveillance after microsurgery for vestibular schwannoma
Authors: Miller Mia E. , Lin Harrison , Mastrodimos Bill , Cueva Roberto A. 
Published: March 2017

ObjectivesTo determine the optimal postoperative magnetic resonance imaging (MRI) schedule and length of follow‐up for patients undergoing microsurgical excision of vestibular schwannoma (VS).Study DesignA retrospective review of patients who underwent microsurgical excision of VS at a single tertiary care center between January 1993 and March 2004.MethodsTwo hundred and twenty subjects were analyzed and characteristics gathered, including tumor size, surgical approach, completeness of resection, and length of follow‐up to last MRI. All postoperative MRIs were reviewed. Radiologic progression is defined as a transition to a more advanced MRI grade from a less advanced MRI grade (eg, clean, linear, nodular) and was recorded for each of the subjects' serial MRIs. The MRI categorized findings were also binned into five time periods for summary analyses. Interval‐censored survival analysis was performed to model time to recurrence across the population.ResultsOf the non‐neurofibromatosis type 2 (NF2) cohort, the average tumor size at the time of resection was 1.98 ± 1.02 cm (range 0.4–5 cm); average length of follow‐up was 9.0 ± 4.6 years (range 1–19); 102 subjects (47.2%) underwent a retrosigmoid resection; and 110 (50.9%) underwent a translabyrinthine resection. Eight of these subjects (4.1%) demonstrated radiologic progression; of those, four underwent additional treatment. Survival analysis showed early (1–2 years postoperative), middle (2–10 years postoperative), and late (> 10 years postoperative) radiologic progression events.ConclusionThe current recommended MRI surveillance schedule after microsurgery for VS includes MRIs at 1, 5, and 10 years postoperatively. Nonparametric survival analysis suggests that a majority of radiologic progression events occur in the first 10 years postoperatively.Level of Evidence4. Laryngoscope, 127:2132–2138, 2017
Sections of the regular simplex – Volume formulas and estimates
Authors: Dirksen Hauke 
Published: March 2017

AbstractWe state a general formula to compute the volume of the intersection of the regular n‐simplex with some k‐dimensional subspace. It is known that for central hyperplanes the one through the centroid containing vertices gives the maximal volume. We show that, for fixed small distances of a hyperplane to the centroid, the hyperplane containing vertices is still volume maximizing. The proof also yields a new and short argument for the result on central sections. With the same technique we give a partial result for the minimal central hyperplane section. Finally, we obtain a bound for k‐dimensional sections.
High‐resolution dynamic oxygen‐17 MR imaging of mouse brain with golden‐ratio–based radial sampling and k‐space–weighted image reconstruction
Authors: Liu Yuchi , Zhang Yifan , Wu Chunying , Zhu Junqing , Wang Charlie , Tomko Nicholas , Linetsky Mikhail D. , Salomon Robert G. , Ramos‐Estebanez Ciro , Wang Yanming , Yu Xin 
Published: March 2017

PurposeThe current study aimed to develop a three‐dimensional (3D) dynamic oxygen‐17 (17O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of 17O water uptake and washout in the brains of mice with glioblastoma (GBM).MethodsA 3D imaging method with a stack‐of‐stars golden‐ratio–based radial sampling scheme was employed to acquire 17O signal in vivo. A k‐space–weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution. Simulation studies were performed to validate the method. Using this method, the kinetics of 17O water uptake and washout in the brains of mice with GBM were delineated after an intravenous bolus injection of 17O water.ResultsThe proposed 17O imaging method achieved an effective temporal resolution of 7.56 s with a nominal voxel size of 5.625 μL in the mouse brain at 9.4 T. Reduced uptake and prolonged washout of 17O water were observed in tumor tissue, suggesting compromised cerebral perfusion.ConclusionThis study demonstrated a promising dynamic 17O imaging approach that can delineate 17O water kinetics in vivo with high temporal and spatial resolution. It can also be used to image cerebral oxygen consumption rate in oxygen‐17 inhalation studies. Magn Reson Med 79:256–263, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Block triangular preconditioners for linearization schemes of the Rayleigh–Bénard convection problem
Authors: Ke Guoyi , Aulisa Eugenio , Bornia Giorgio , Howle Victoria 
Published: March 2017

SummaryIn this paper, we compare two block triangular preconditioners for different linearizations of the Rayleigh–Bénard convection problem discretized with finite element methods. The two preconditioners differ in the nested or nonnested use of a certain approximation of the Schur complement associated to the Navier–Stokes block. First, bounds on the generalized eigenvalues are obtained for the preconditioned systems linearized with both Picard and Newton methods. Then, the performance of the proposed preconditioners is studied in terms of computational time. This investigation reveals some inconsistencies in the literature that are hereby discussed. We observe that the nonnested preconditioner works best both for the Picard and for the Newton cases. Therefore, we further investigate its performance by extending its application to a mixed Picard–Newton scheme. Numerical results of two‐ and three‐dimensional cases show that the convergence is robust with respect to the mesh size. We also give a characterization of the performance of the various preconditioned linearization schemes in terms of the Rayleigh number.
Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
Authors: Fischer Thomas , Riedl Rainer 
Published: March 2017

AbstractInvited for this month's cover picture is the group of Professor Rainer Riedl from the Institute of Chemistry and Biotechnology at the Zurich University of Applied Sciences (ZHAW), Switzerland. The cover picture depicts the structure‐based design of a drug‐like small molecule inhibitor of matrix metalloproteinase‐13 (MMP‐13) with a combined dual binding motif. The targeted introduction of a single fluoro atom was of vital importance for the optimization of the inhibitor. For more details, read the full text of the Communication at 10.1002/open.201600158.
Synergistic enhancement of crystallization and mechanical performance of polypropylene random copolymer by strong shear and β‐nucleating agent
Authors: Qi Yanxin , Zhang Chunbo , Zhao Ying , Wang Dujin , Lei Jun , Li Zhongming 
Published: March 2017

AbstractInvestigation of microstructure and properties is critical for the development and application of polymer materials. Polypropylene random copolymer (PPR) and β‐nucleatedPPRare widely used in water pipe production. The effect of melt shear flow on the crystalline structure and mechanical properties ofPPRcontaining β‐nucleating agent needs in‐depth understanding. In this paper, we demonstrated the preparation ofPPRandPPRcontaining 0.1 wt% calcium pimelate (Ca‐Pim) samples by conventional injection molding (CIM) and oscillation shear injection molding (OSIM). The multilayer structures and morphologies of the samples were characterized bySEM, two‐dimensional X‐ray scattering andDSC. The mechanical properties and the microstructures of samples prepared by these two injection molding methods were compared. Compared with samples prepared byCIM, the stronger shear provided byOSIMinduced the formation of a thicker layer of a shish‐kebab structure and a higher content of γ crystals, and dramatically suppressed the β‐nucleating effect of Ca‐Pim. TheOSIMsamples have more shish‐kebab structures and higher crystallinities thanCIMsamples and therefore the former exhibit better rigidity than the latter. The β crystals in the core layer and the thicker layer of shish‐kebab structure endowOSIM‐PPR/0.1 wt% Ca‐Pim with excellent impact toughness. © 2017 Society of Chemical Industry
Feasibility and Efficacy of Intra-Arterial Administration of Mesenchymal Stem Cells in an Animal Model of Double Toxin-Induced Multiple System Atrophy
Authors: Na Kim Ha , Yeol Kim Dong , Hee Oh Se , Sook Kim Hyung , Suk Kim Kyung , Hyu Lee Phil 
Published: March 2017

Abstract
Multiple system atrophy (MSA) is a sporadic neurodegenerative disease of the central and autonomic nervous system. Because no drug treatment consistently benefits MSA patients, neuroprotective strategy using mesenchymal stem cells (MSCs) has a lot of concern for the management of MSA. In this study, we investigated the safety and efficacy of intra-arterial administration of MSCs via internal carotid artery (ICA) in an animal model of MSA. The study was composed of feasibility test using a ×10 and ×50 of a standard dose of MSCs (4 × 107 MSCs) and efficacy test using a ×0.2, ×2, and ×20 of the standard dose. An ultrasonic flow meter and magnetic resonance imaging (MRI) showed that no cerebral ischemic lesions with patent ICA blood flow was were observed in animals receiving a ×10 of the standard dose of MSCs. However, no MSA animals receiving a ×50 of the standard dose survived. In efficacy test, animals injected with a ×2 of the standard dose increased nigrostriatal neuronal survival relative to a ×0.2 or ×20 of the standard dose. MSA animals receiving MSCs at ×0.2 and ×2 concentrations of the standard dose exhibited a significant reduction in rotation behavior relative to ×20 of the standard dose of MSCs. Cerebral ischemic lesions on MRI were only observed in MSA animals receiving a ×20 of the standard dose. The present study revealed that if their concentration is appropriate, intra-arterial injection of MSCs is safe and exerts a neuroprotective effect on striatal and nigral neurons with a coincidental improvement in motor behavior.
A Simple, Efficient Green Protocol for the Synthesis of β‐Enaminone and Enamino Ester Derivatives by Using Onion Extract as Green Catalyst
Authors: Prabakaran Kaliyan , Sivakumar Matam , Perumal Muthu Seenivasa 
Published: March 2017

AbstractWe have developed an environmental friendly and highly efficient method for onion extract catalyzed enamination of 1,3‐dicarbonyl compounds and primary amines. This method is applicable to a wide range of aromatic/aliphatic/heterocyclic amines with active methylene compounds, and affords the β‐enaminone and enamino ester derivatives in good to excellent yields (up to 97 %) in an eco‐friendly solvent ethanol at room temperature. The use of onion extract makes the process environmentally benign.
Synthesis, Photophysical Studies on Some Anthracene–based Ionic Liquids and their Application as Biofilm Formation Inhibitor
Authors: Jha Gaurav , Sahu Prabhat Kumar , Panda Sasmita , Singh Durg V. , Patole Shashank , Mohapatra Harapriya , Sarkar Moloy 
Published: March 2017

AbstractImidazolium based monocationic and dicationic ionic liquids, with an anthracene moiety covalently attached to the imidazolium ions, via a methyl spacers, have been synthesized and their photophysical and biological studies have been carried out. Photophysical investigations have revealed that the monocationic anthracene based ionic liquid, AnILBr, exhibits a higher fluorescence quantum yield and average fluorescence lifetime compared to its parent fluorophore anthracene. For dication based systems (AnIL2Br2), the photophysical data have demonstrated that the attachment of two imidazolium cations on anthracene ring, leads to even further fluorescent enhancement. The quantum yield, average lifetime, red‐shifts of absorption and emission for AnIL2Br2 are observed to be relatively higher as compared to AnILBr. This observations illustrate that the imidazolium cation influences the electronic energy distribution in the fluorophore, in such a way, that it leads to enhancement of photoluminescence. Since ionic liquids have recently been shown to demonstrate anti‐biofilm activity, the potential of AnILBr, as a biofilm formation inhibiting agent has also been explored in details. The assay has revealed that addition of AnILBr up to 4 hours significantly inhibited the biofilm formed by both the strains, and this can be utilized to enhance the effectiveness of an antibacterial drug, when used along with AnILBr.
Pressurized Hot Water Extraction as a Viable Bioprospecting Tool: Isolation of Coumarin Natural Products from Previously Unexamined Correa (Rutaceae) Species
Authors: Deans Bianca J. , Just Jeremy , Chhetri Jamuna , Burt Liam K. , Smith James N. , Kilah Nathan L. , de Salas Miguel , Gueven Nuri , Bissember Alex C. , Smith Jason A. 
Published: March 2017

AbstractThe potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)‐epoxysuberosin, alosin, (–)‐meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)‐trachypleuranin A and (–)‐yuehgesin B. In addition, seselin, (+)‐epoxysuberosin, alosin, and (–)‐meranzin were found to inhibit NQO1 activity. Interestingly, (–)‐meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.
The Key Role of Textural Properties of Aluminosilicates in the Acid‐Catalysed Dehydration of Glucose into 5‐Hydroxymethylfurfural
Authors: Moreno‐Recio Mercedes , Jiménez‐Morales Ignacio , Arias Pedro L. , Santamaría‐González José , Maireles‐Torres Pedro 
Published: March 2017

AbstractThree protonated zeolites (H‐ZSM‐5, H‐Y and H‐Beta) were prepared and tested in the catalytic dehydration of glucose into 5‐hydroxymethylfurfural (HMF). The catalytic results are compared with those obtained with a mesoporous MCM‐41‐type aluminosilicate, in order to assess the influence of textural and acid properties on the catalytic performance. The dehydration process was carried out in a biphasic water/methyl‐isobutyl ketone (MIBK) system, and the positive effect of NaCl addition (20 wt. %) on both HMF selectivity and yield was observed. Using the H‐Beta zeolite in a NaCl aqueous solution/MIBK, at 195 °C, the best catalytic results were obtained, with a HMF yield of 56%, close to that obtained with 10Al‐MCM‐41 (63%), after only 30 min of reaction time; whereas HMF yields rose only up to 42% using H‐ZSM‐5 and H‐Y. This fact demonstrates the positive effect of mesoporosity to favour the dehydration of glucose to HMF. The reutilisation of these catalysts was also examined.
Dimethylsulfoxide/Water Mixed Solvent Mediated Synthesis of 5‐Hydroxymethylfurfural from Galactose with Aluminum Salt Catalyst
Authors: Jia Songyan , He Yangdong , Wang Guosheng 
Published: March 2017

AbstractAs a biomass‐derived platform compound, 5‐hydroxymethylfurfural (5‐HMF) has attracted many researchers’ interest. Effective conversion of fructose, glucose and their polymers into 5‐HMF provides new perspectives for biomass utilization. However, other underused hexoses have received much less attention in the field of 5‐HMF production. In this work, galactose was effectively converted into 5‐HMF under mild conditions. AlCl3•6H2O showed superior catalytic activity for the production of 5‐HMF in a DMSO/H2O mixed solvent system. Adding an appropriate amount of water in DMSO may have improved the solubility of AlCl3•6H2O and suppressed side reactions, significantly increasing 5‐HMF yield and selectivity. The system was also efficient for the conversion of lactose into 5‐HMF. Control experiments with different catalysts and simple model compounds provided mechanistic insights.
π‐Conjugated Indole Dyads with Strong Blue Emission Made Possible by Stille Cross‐Coupling and Double Fischer Indole Cyclisation
Authors: Garrote Cañas Ana M. , Martsinovich Natalia , Sergeeva Natalia N. 
Published: March 2017

AbstractSmall fluorescent π‐conjugated indolyl‐based molecules4–6,23are prepared through direct Fischer synthesis or/and Stille cross‐coupling method in appreciable yields. Our synthetic results have shown the benefits using Stille approach when Fischer double cyclisation method to access the bisindole dyads4–6,23is not efficient. The synthetic routes to these materials have been designed to investigate the substrate requirements for the respective cyclisation and CC‐coupling reactions and to evaluate their wider synthetic applicability. Comparative analysis of the different substituents and the different π‐bridging units e. g. pyridine, thiophene and thiazole on the electronic and photophysical properties of the final compounds4–6,23has been carried out. The structure−property relationship of the final bisindole dyads has been investigatedviaphotophysical characterisation, and computational modelling. The obtained compounds absorb near‐UV and visible (blue) light, with the spectral range dependent on the nature of the π‐bridging units, and are capable of bright blue emission.
Peapod Assemblies of Au and Au/Pt Nanoparticles Encapsulated within Hollow Silica Nanotubes
Authors: Byoun Wongyun , Yoo Hyojong 
Published: March 2017

AbstractNanoparticle assemblies within hollow nanoshells represent versatile structures which enable efficient nanosystems with colligative properties of nanoparticles for a variety of applications. In this report, we present a simple and high yielding solution‐based synthetic strategy for peapod‐shaped Au nanoparticle assembly encapsulated within hollow silica nanotubes (pp multi‐Au@SiO2 NTs). One‐dimensional, [multiple Au nanodot] core–[silica] shell nanowires (multi‐Au@SiO2 NWs) are preferentially synthesized based on reverse microemulsion (water‐in‐oil) techniques. By thermal treatment of multi‐Au@SiO2 NWs in aqueous polyvinylpyrrolidone (PVP) solution, pp multi‐Au@SiO2 NTs can be successfully fabricated. Further growth of Pt on the Au nanoparticles in pp multi‐Au@SiO2 NTs can lead to the generation of [Au] core‐[Pt] shell (Au/Pt) nanoparticle assembly surrounded by silica nanotubes (pp multi‐Au/Pt@SiO2 NTs).
Direct Conversion of Cellulose into Alkyl Glycoside Surfactants
Authors: Puga Alberto V. , Corma Avelino 
Published: March 2017

AbstractThe one‐step production of biodegradable alkyl glycoside (1‐dodecyl mono‐ and oligoglucoside) surfactants from cellulose has been achieved by direct alcoholysis in fatty alcohol media under Brønsted acid catalysis at near‐ambient pressure. The fatty alcohol serves as both solvent and reagent. Addition of small amounts of water prevents dehydration events and thus minimises product and solvent degradation. Furthermore, high initial cellulose loadings and short thermal cycles enable moderate‐to‐high conversions and selectivities (up to ≈ 70 %), and low solvent‐to‐product ratios.
Improving spectral‐based fault localization using static analysis
Authors: Neelofar Neelofar , Naish Lee , Lee Jason , Ramamohanarao Kotagiri 
Published: March 2017

SummaryDebugging is crucial for producing reliable software. One of the effective bug localization techniques is spectral‐based fault localization (SBFL). It helps to locate a buggy statement by applying an evaluation metric to program spectra and ranking program components on the basis of the score it computes. SBFL is an example of a dynamic analysis – an analysis of computer program that is performed by executing it with sufficient number of test cases. Static analysis, on the other hand, is performed in a non‐runtime environment. We introduce a weighting technique by combining these two kinds of program analysis. Static analysis is performed to categorize program statements into different classes and giving them weights based on the likelihood of being buggy statement. Statements are finally ranked on the basis of the weights computed by statements' categorization (static analysis) and scores computed by SBFL metrics (dynamic analysis). We evaluate the performance of our technique on Siemens test suite and Flex (having seeded bugs seeded by expert developers), Sed (having mixture of real and seeded bugs), and Space (having real bugs). In our evaluation, proposed weighting technique improves the performance of a wide variety of fault localization metrics up to 20% on single bug datasets and up to 42% on multi‐bug datasets. Copyright © 2017 John Wiley & Sons, Ltd.