bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the demographics of intravenous drug users with mycotic common femoral artery pseudoaneurysm as a consequence of self-injection does not influence outcome following emergency ligation
Authors: Stevenson Richard P , Semple Catriona , Hussey Keith , McGovern Josh , Stuart Wesley P , Kingsmore David B 
Published: March 2017

Objectives The reported annual incidence of mycotic pseudoaneurysm of the common femoral artery in intravenous drug users has been estimated at 0.03%. Over the past 5 years in Scotland, the proportion of people receiving specialist attention for heroin use over the age of 40 years has increased from 15 to 22%. Although routinely managed with arterial ligation (without reconstruction), some series have reported rates of major limb amputation of up to 10%. We sought to define whether this management strategy was still acceptable in an older population. Methods Retrospective review of patients presenting to a tertiary vascular service with mycotic pseudoaneurysm of the common femoral artery due to arterial injection by intravenous drug users between October 2010 and March 2016. Variables of interest included patient demographics and requirement for major amputation. Results There were 55 patients identified. The annual incidence of mycotic pseudoaneurysm of the common femoral artery in intravenous drug users was 2.1%. It was more common in men (3:1) and the mean age at presentation was 41 years (standard deviation ± 8 years). Three patients underwent major limb amputation during the index admission for severe limb ischaemia (two transfemoral amputations; one hip-disarticulation). Following discharge two patients were readmitted (134 and 200 days, respectively, following primary ligation) for major limb amputation due to of critical limb ischaemia. Conclusions Despite the increasing age of intravenous drug users presenting with mycotic pseudoaneurysm of the common femoral artery primary ligation of pseudoaneurysm would seem to remain an appropriate therapeutic intervention.
Indirect effect of management support on users’ compliance behaviour towards information security policies
Authors: Humaidi Norshima , Balakrishnan Vimala 
Published: March 2017

Background: Health information systems are innovative products designed to improve the delivery of effective healthcare, but they are also vulnerable to breaches of information security, including unauthorised access, use, disclosure, disruption, modification or destruction, and duplication of passwords. Greater openness and multi-connectedness between heterogeneous stakeholders within health networks increase the security risk. Objective: The focus of this research was on the indirect effects of management support (MS) on user compliance behaviour (UCB) towards information security policies (ISPs) among health professionals in selected Malaysian public hospitals. The aim was to identify significant factors and provide a clearer understanding of the nature of compliance behaviour in the health sector environment. Method: Using a survey design and stratified random sampling method, self-administered questionnaires were distributed to 454 healthcare professionals in three hospitals. Drawing on theories of planned behaviour, perceived behavioural control (self-efficacy (SE) and MS components) and the trust factor, an information system security policies compliance model was developed to test three related constructs (MS, SE and perceived trust (PT)) and their relationship to UCB towards ISPs. Results: Results showed a 52.8% variation in UCB through significant factors. Partial least squares structural equation modelling demonstrated that all factors were significant and that MS had an indirect effect on UCB through both PT and SE among respondents to this study. Conclusion: The research model based on the theory of planned behaviour in combination with other human and organisational factors has made a useful contribution towards explaining compliance behaviour in relation to organisational ISPs, with trust being the most significant factor. In adopting a multidimensional approach to management–user interactions via multidisciplinary concepts and theories to evaluate the association between the integrated management–user values and the nature of compliance towards ISPs among selected health professionals, this study has made a unique contribution to the literature.
Health care to empower self-care in adolescents with type 1 diabetes mellitus and an immigrant minority background
Authors: Boman Åse , Bohlin Margareta , Eklöf Mats , Forsander Gun , Munthe Christian , Törner Marianne 
Published: March 2017

Background: The pediatric diabetes team aims to support health, quality of life, and normal growth and development among adolescents with type 1 diabetes mellitus. Adolescents with an immigrant background have been found less successful in self-care. Previous research indicated that adolescents who had integrated the disease as a part of their self-image reasoned differently about their self-care to those who had not. Objective: The aim of this study was to identify elements in the patient–pediatrician consultations that might influence such integration of the disease among adolescents with type 1 diabetes mellitus. Methods: A total of 12 pediatrician–adolescent consultations were video-recorded and analyzed. The adolescents all had an immigrant background. Results: Integration of the disease appeared enabled when responsibility was shared; when hope, autonomy, and emotions were confirmed; and when the pediatrician asked probing questions. Letting objective data dominate the adolescent’s experiences, using risk as a motivator, neutralizing emotions in relation to having diabetes, and confirming forgetfulness, may instead inhibit disease integration. Conclusion: An extended person-centered approach with focus on the adolescent’s experiences of everyday life with a chronic disease and less attention on physical parameters in the pediatrician–adolescent consultations may increase integration of the disease.
Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model
Authors: Hampton Caryn , Rosa Raymond , Szeto Daphne , Forrest Gail , Campbell Barry , Kennan Richard , Wang Shubing , Huang Chin-Hu , Gichuru Loise , Ping Xiaoli , Shen Xiaolan , Small Kersten , Madwed Jeffrey , Lynch Joseph J 
Published: March 2017

Introduction: Despite the widespread use of the mouse transverse aortic constriction heart failure model, there are no reports on the characterization of the standard-of-care agent carvedilol in this model. Methods: Left ventricular pressure overload was produced in mice by transverse aortic constriction between the innominate and left common carotid arteries. Carvedilol was administered at multiple dose levels (3, 10 and 30 mg/kg/day per os; yielding end-study mean plasma concentrations of 0.002, 0.015 and 0.044 µM, respectively) in a therapeutic design protocol with treatment initiated after the manifestation of left ventricular remodeling at 3 weeks post transverse aortic constriction and continued for 10 weeks. Results: Carvedilol treatment in transverse aortic constriction mice significantly decreased heart rate and left ventricular dP/dt (max) at all dose levels consistent with β-adrenoceptor blockade. The middle dose of carvedilol significantly decreased left ventricular weight, whereas the higher dose decreased total heart, left and right ventricular weight and wet lung weight compared to untreated transverse aortic constriction mice. The higher dose of carvedilol significantly increased cardiac performance as measured by ejection fraction and fractional shortening and decreased left ventricular end systolic volume consistent with the beneficial effect on cardiac function. End-study plasma sST-2 and Gal-3 levels did not differ among sham, transverse aortic constriction control and transverse aortic constriction carvedilol groups. Plasma b rain natriuretic peptide concentrations were elevated significantly in transverse aortic constriction control animals (~150%) compared to shams in association with changes in ejection fraction and heart weight and tended to decrease (~30%, p = 0.10–0.12) with the mid- and high-dose carvedilol treatment. Conclusion: A comparison of carvedilol hemodynamic and structural effects in the mouse transverse aortic constriction model versus clinical use indicates a strong agreement in effect profiles preclinical versus clinical, providing important translational validation for this widely used animal model. The present plasma brain natriuretic peptide biomarker findings support the measurement of plasma natriuretic peptides in the mouse transverse aortic constriction model to extend the translational utility of the model.
Association of provider opioid prescribing practices and the Centers for Medicare and Medicaid Services hierarchical condition category score: A retrospective examination of correlation between the volume of provider-prescribed opioid medications and provider panel complexity
Authors: North Frederick , Tulledge-Scheitel Sidna M , Crane Sarah J 
Published: March 2017

Objective: Opioids are being prescribed at increasing rates in primary care practices, and among individual providers there is significant variability in opioid prescribing. Primary care practices also vary significantly in complexity of their patients, ranging from healthy patients to those with multiple comorbidities. Our objective was to examine individual primary care providers for an association between their opioid prescribing and the complexity/risk of their panel of patients (a panel of patients is a group of patients whose medical care is the responsibility of a specific healthcare provider or care team). Methods: We retrospectively examined 12 months of opioid prescription data from a primary care practice. We obtained counts of opioids prescribed by providers in the Mayo Clinic, Rochester, Minnesota primary care practice. For patients paneled (assigned) to family medicine and internal medicine, we used the Centers for Medicare and Medicaid Services hierarchical condition category patient risk score as a measure of patient complexity. After adjusting the opioid counts for panel patient count (to get opioid counts per patient), we used linear regression analysis to determine the correlation between the hierarchical condition category risk and the amount of opioid prescribed by individual providers. Results: Among our combined 103 primary care providers, opioid unit counts prescribed per patient were highly correlated with the providers’ hierarchical condition category panel risk score (r2 = 0.54). After excluding three outliers, r2 was 0.74. With and without the outliers, the correlation was very significant (p < 0.0001). Subgroup analysis of panels with hierarchical condition category ⩽ 0.45 showed no correlation of opioid prescribing volume with hierarchical condition category (r2 < 0.02; p = 0.32). Provider panels with hierarchical condition category > 0.45 showed significant correlation with hierarchical condition category (r2 = 0.26; p = 0.001). Conclusion: When examining differences in primary care providers’ opioid prescribing practices, the Centers for Medicare and Medicaid Services endorsed risk score (the hierarchical condition category score) can help adjust for population differences of a provider’s patients.
Novel combined patient instruction and discharge summary tool improves timeliness of documentation and outpatient provider satisfaction
Authors: Gilliam Meredith , Krein Sarah L , Belanger Karen , Fowler Karen E , Dimcheff Derek E , Solomon Gabriel 
Published: March 2017

Background: Incomplete or delayed access to discharge information by outpatient providers and patients contributes to discontinuity of care and poor outcomes. Objective: To evaluate the effect of a new electronic discharge summary tool on the timeliness of documentation and communication with outpatient providers. Methods: In June 2012, we implemented an electronic discharge summary tool at our 145-bed university-affiliated Veterans Affairs hospital. The tool facilitates completion of a comprehensive discharge summary note that is available for patients and outpatient medical providers at the time of hospital discharge. Discharge summary note availability, outpatient provider satisfaction, and time between the decision to discharge a patient and discharge note completion were all evaluated before and after implementation of the tool. Results: The percentage of discharge summary notes completed by the time of first post-discharge clinical contact improved from 43% in February 2012 to 100% in September 2012 and was maintained at 100% in 2014. A survey of 22 outpatient providers showed that 90% preferred the new summary and 86% found it comprehensive. Despite increasing required documentation, the time required to discharge a patient, from physician decision to discharge note completion, improved from 5.6 h in 2010 to 4.1 h in 2012 (p = 0.04), and to 2.8 h in 2015 (p < 0.001). Conclusion: The implementation of a novel discharge summary tool improved the timeliness and comprehensiveness of discharge information as needed for the delivery of appropriate, high-quality follow-up care, without adversely affecting the efficiency of the discharge process.
Customer-centric Circles, the Self-directed Approach to Service and Mindset Changes
Authors: Mahajan Gautam 
Published: March 2017

Front-line people are typically trained so as to modify their behaviour and actions. Unfortunately, these training programmes do not impact the behaviour, though they are useful in imparting skills. This article describes customer-centric circles, and the resultant benefits in customer focus, team work and improved service value creation. Much of this is done through mindset changes that occur when front-line people are self-directed and self-motivated. Customer-centric circles (shortened to customer circles) were started in companies from around 2004. This article describes customer circles; how customer circles can create/add value to the firms including their employees and mostly for customers, particularly in the service area and in team work and customer focus; customer circles are compared to traditional training programmes; and how customer circles can be implemented in the internal structure/organization and challenges. Cases of customer circles are discussed. The front-line people can be in various disciplines such as manufacturing, administration and sustainability.
Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing
Authors: Acuff Nicole V , Li Xin , Elmore Jessica , Rada Balázs , Watford Wendy T 
Published: March 2017

Abstract
Tumor progression locus 2 (Tpl2) is a serine/threonine kinase that promotes inflammatory cytokine production by activating the MEK/ERK pathway. Tpl2 has been shown to be important for eliciting the inflammatory properties of macrophages; however, there is relatively little known about the contribution of Tpl2 to neutrophil effector functions. This is an important consideration, as neutrophils provide the first line of defense against infection in the innate immune system. We found that Tpl2 is expressed in both human and murine neutrophils, suggesting a potential function for Tpl2 in this lineage. Despite significantly higher proportions of bone marrow (BM) neutrophils in Tpl2-deficient (Tpl2−/−) mice compared with wild-type (WT) mice, Tpl2−/− mice have significantly reduced proportions of circulating neutrophils. Tpl2−/− neutrophils show impaired recruitment to thioglycollate, which was primarily a result of neutrophil-extrinsic factors in the host. In response to infection, neutrophils secrete inflammatory cytokines and produce reactive oxygen species (ROS), which promote bacterial killing. Tpl2 ablation impaired neutrophil TNF secretion in response to LPS stimulation, superoxide generation in response to the chemotactic peptide fMLP, and killing of the extracellular bacterium, Citrobacter rodentium, despite normal bacterial phagocytosis. These results implicate Tpl2 in the regulation of multiple neutrophil antimicrobial pathways, including inflammatory cytokine secretion and oxidative burst. Furthermore, they indicate that Tpl2 functions early during infection to bolster neutrophil-mediated innate immunity against extracellular bacteria.
Determination of inorganic element distribution in the freeze-fixed stem of Al2(SO4)3-treated Hydrangea macrophylla by TOF-SIMS and ICP-AES
Authors: Zheng Peiming , Ito Takaaki , Aoki Dan , Sato Saori , Yoshida Masato , Sano Yuzou , Matsushita Yasuyuki , Fukushima Kazuhiko , Yoshida Kumi 
Published: March 2017

Abstract
To elucidate the effect of soil conditions on the in planta distribution of inorganic elements, an aluminium (Al)-tolerant plant, Hydrangea macrophylla, was cultivated with the addition of Al ion to soils. Freeze-dried stems from the plants were analysed by time-of-flight secondary ion mass spectrometry (dry-TOF-SIMS). Freeze-fixed stems of the plants were analysed by cryo-TOF-SIMS. The inorganic metal content was quantified by inductively coupled plasma atomic absorption spectrometry (ICP-AES). The dry- and cryo-TOF-SIMS mapping analyses showed that in the native sample, inorganic elements are mainly localised in the cortex and pith. Al-treatment [i.e. Al2(SO4)3 administration to the soil] altered the distribution and content of inorganic metals. The actual amount of inorganic elements quantified by ICP-AES showed that Al-treatment on the soil increased the amounts of Na, Mg, Al and Ca and decreased that of K in the stem. The secondary ion counts of inorganic elements in freeze-dried and -fixed samples, determined by dry-/cryo-TOF-SIMS measurements, showed similar variations as that observed with ICP-AES measurements. These results are interpreted as that Al-treatment altered the distribution and amount of inorganic elements in the stems of Al-tolerant H. macrophylla plants.
A novel testis-specific protein, PRAMEY, is involved in spermatogenesis in cattle
Authors: Liu Wan-Sheng , Zhao Yaqi , Lu Chen , Ning Gang , Ma Yun , Diaz Francisco , O'Connor Michael 
Published: March 2017

Preferentially expressed antigen in melanoma (PRAME) is a cancer/testis antigen that is predominantly expressed in normal testicular tissues and a variety of tumors. The function of the PRAME family in spermatogenesis remains unknown. This study was designed to characterize the Y-linked PRAME (PRAMEY) protein during spermatogenesis in cattle. We found that PRAMEY is a novel male germ cell-specific, and a germinal granule-associated protein that is expressed in spermatogenic cells during spermatogenesis. The intact PRAMEY protein (58 kDa) was detected in different ages of testes but not in epididymal spermatozoa. A PRAMEY isoform (30 kDa) was highly expressed only in testes after puberty and in epididymal spermatozoa. This isoform interacts with PP1γ2 and is likely the mature protein present in the testes and sperm. Immunofluorescent staining demonstrated that PRAMEY was located predominantly in the acrosome granule of spermatids, and in acrosome and flagellum of spermatozoa. Immunogold electron microscopy further localized the PRAMEY protein complex to the nucleus and several cytoplasmic organelles, including the rough endoplasmic reticulum, some small vesicles, the intermitochondrial cement, the chromatoid body and the centrioles, in spermatogonia, spermatocytes, spermatids and/or spermatozoa. PRAMEY was highly enriched in and structurally associated with the matrix of the acrosomal granule (AG) in round spermatids, and migrated with the expansion of the AG during acrosomal biogenesis. While the function of PRAMEY remains unclear during spermatogenesis, our results suggest that PRAMEY may play an essential role in acrosome biogenesis and spermatogenesis.Free Chinese abstract: A Chinese translation of this abstract is freely available athttp://www.reproduction-online.org/content/153/6/847/suppl/DC2Spanish abstract: A Spanish translation of this abstract is freely available athttp://www.reproduction-online.org/content/153/6/847/suppl/DC3
TAKSONOMI TRANSENDEN (PARADIGMA BARU TUJUAN PENDIDIKAN ISLAM)
Authors: Fuad Ah. Zakki 
Published: March 2017

<em>The Taxonomy of the Objectives of Islamic Education in the Qur'anic Perspective. This study is initiated from a thought that "the objective of Islamic education is to make students good". The word "good" becomes the key as well as the entrance to formulate the objective of Islamic education in this study, namely by examining the concept of "good" in the Qur’an. The concept studied by using a model of thematic tafsir (mawdhu’iy) approach. With this approach the word "good" was sought through three stems, i.e., the words ahsana-yuhsinu, saluha-yasluhu and khairun with their various shapes and changes in al-Qur’an. Then the classification arranged using the theory of taxonomy. The focus of this research conducted is: How is the taxonomy of the objectives of Islamic education in the Qur’an perspective. The finding this research of the objectives of Islamic education taxonomy is called the Trancendent Taxonomy. Namely the classification of the objectives of Islamic education which is divided into three dimensions based on the Holy Qur’an, these are ilahiyyah (divinity), insaniyyah (humanity) and kauniyyah (naturality) dimensions.</em>
Some Uterine and Ovarian Biometric Changes in Pregnant Maradi Female Goats (Capra aegagrus hircus L.)
Authors: OKOYE Chidozie Nwabuisi , ABIAEZUTE Clifford Nwabugwu , EKERE Okezie Samuel 
Published: March 2017

This study aimed to determine the changes in the biometry of the ovaries, of the uteri and its contents in the Maradi doe-goat during the three terms of pregnancy. Pregnant uteri from 28 female goats and their corresponding ovaries were used to study the biometric changes in the ovaries, gravid uteri, amniotic and allantoic fluids volumes, fetuses and plancentomes during the three terms of pregnancy. The results revealed that there was no significant variation in the ovarian weight during the three terms of pregnancy. However, there were significant variations in the ovarian length (left ovary 2.15 ± 0.16 cm; right ovary 2.10 ± 0.10 cm) and width (left ovary 1.77 ± 0.19 cm; right ovary 1.60 ± 0.10 cm) in the third term of pregnancy compared to the ovarian length and width in the first term of pregnancy. The uterine weight showed significant variation in the first term, second term and in the third term of pregnancy. The uterine length of both horns also showed significant variations in the first term (left side 31.40 ± 1.79 cm; right side 28.22 ± 0.98 cm), second term (left side 51.58 ± 4.14 cm; right side 50.51 ± 3.62 cm) and in the third term (left side 70.67 ± 1.76 cm; right side 80.38 ± 2.75 cm) of pregnancy but only in the third term of pregnancy was a significant difference in the lengths of the left side uterine horn (70.67 ± 1.76 cm) compared to the right side (80.38 ± 2.75 cm). The number of plancentomes was constant in both uterine horns throughout gestation; however the mean caruncular diameter increased progressively from the first term of gestation through the third term of pregnancy. The smallest and largest caruncles were observed on the ventral surfaces of the uterine horns, and the plancentomes were observed to be aligned in a linear manner along the longitudinal axis of the uterine horns. This study shows that there are differences in the biometrics of the ovary and uterus in Maradi goats compared to some other breed.