bluuebunny/crossref_metadata_2025_split huggingface dataset:
Editorial: avoiding corticosteroids in the treatment of inflammatory bowel disease—Author's reply
Authors: Selinger C. P. , Parkes G. C. , Raine T. 
Published: December 2017

Linked ContentThis article is linked to Colizzo and Friedman, and Selinger et al papers. To view these articles visit https://doi.org/10.1111/apt.14399 and https://doi.org/10.1111/apt.14334.
Editorial: anti‐TNF therapy and myopenia in Crohn's disease—another step towards personalised medicine. Authors’ reply
Authors: Ding N. S. , Malietzis G. , Hart A. L. 
Published: December 2017

Linked ContentThis article is linked to Ding et al and Murray papers. To view these articles visit https://doi.org/10.1111/apt.14293 and https://doi.org/10.1111/apt.14392.
Letter: oesophageal histological abnormalities and GERD ‐ an underestimated relationship requiring more attention
Authors: Savarino E. , Lorenzon G. , Facchin S. , Savarino V. 
Published: December 2017

Linked ContentThis article is linked to Vakil et al paper. To view this article visit https://doi.org/10.1111/apt.14028.
The long‐term effects of faecal microbiota transplantation for gastrointestinal symptoms and general health in patients with recurrent Clostridium difficile infection
Authors: Jalanka J. , Hillamaa A. , Satokari R. , Mattila E. , Anttila V.‐J. , Arkkila P. 
Published: December 2017

SummaryBackgroundFaecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection. In short‐term the treatment has been shown to be safe, however, there are no large, long‐term follow‐up studies looking into the potential adverse effects.AimTo analyse the long‐term effect of FMT treatment in patients with recurrent C. difficile infection and to compare the outcome to antibiotic treated patients.MethodsAltogether 84 patients of which 45 received a FMT treatment and 39 served as controls receiving antibiotics for the infection were followed on average for 3.8 years. Their recovery and medical status was evaluated using a retrospective questionnaire, determining their quality of life, gastrointestinal symptoms and new diseases potentially related to the FMT.ResultsThere was no difference in the incidence of severe diseases (inflammatory bowel disease, cancer, autoimmune disease, allergy, neurological diseases) between the patient groups. In addition, weight gain did not differ between treatment groups. The FMT treated patients reported that their bowel habits improved significantly faster, they had less irregular bowel function and less symptoms of upper GI‐tract when compared to the patients treated with antibiotics. Significantly more patients in FMT‐group reported that their mental health improved after the treatment. The willingness to receive FMT treatment for potential new C. difficile infection was significantly higher in both treatment groups compared to other treatment options.ConclusionOur study highlights that FMT is a durable, safe and acceptable treatment option for patients with recurrent C. difficile infection also in long term, and it shows potential benefits over antimicrobial treatment.
Mid‐term results of bariatric surgery in morbidly obese Japanese patients with slow progressive autoimmune diabetes
Authors: Uno Kohei , Seki Yosuke , Kasama Kazunori , Wakamatsu Kotaro , Hashimoto Kenkichi , Umezawa Akiko , Yanaga Katsuhiko , Kurokawa Yoshimochi 
Published: December 2017

AbstractIntroductionBariatric surgery is recognized as an effective treatment for type 2 diabetes mellitus, but data on its efficacy for type 1 diabetes mellitus, especially slowly progressive insulin‐dependent diabetes mellitus, are limited.MethodsWe investigated five Japanese patients with slowly progressive insulin‐dependent diabetes mellitus who underwent bariatric surgery at our center.ResultsFive morbidly obese glutamic acid decarboxylase antibody‐positive diabetic patients underwent two different types of bariatric surgery. The mean titer of anti‐glutamic acid decarboxylase antibody was 4.6 U/mL, and the mean preoperative bodyweight and BMI were 113 kg and 39.6 kg/m2, respectively. The mean hemoglobin A1c was 8.4%. The mean fasting serum C‐peptide was 5.0 ng/mL. Laparoscopic sleeve gastrectomy was performed in two patients, while laparoscopic sleeve gastrectomy with duodenojejunal bypass was performed in three patients. At one year after surgery, the mean bodyweight and BMI significantly dropped, and the mean percentage of excess weight loss was 96.4%. The mean hemoglobin A1c was 5.7%. This favorable trend was maintained at mid‐term.ConclusionBariatric surgery for morbidly obese patients with anti‐glutamic acid decarboxylase antibody–positive type 1 diabetes mellitus, especially slow progressive autoimmune diabetes, seemed effective in achieving mid‐term glycemic control. Longer follow‐up with a larger number of patients, as well as validation with more advanced patients with slowly progressive insulin‐dependent diabetes mellitus, will be needed.
Successful medical management of pseudomembranous cystitis in three cats with lower urinary tract obstruction
Authors: Vila A , Movilla R , Castro J , Mallol C , Novellas R , Espada Y , Roura X 
Published: December 2017

Case reportThe present case series describes the clinical course and outcome of three cats diagnosed with pseudomembranous cystitis. This is an uncommon presentation of lower urinary tract obstruction but can be easily be identified by ultrasonography, revealing severe bladder wall thickening and thin hyperechoic luminal strips. The condition can be secondary to severe bacterial urinary tract infection. All cats were successfully treated with medical management only, mainly based on antimicrobials and individualised supportive therapy.ConclusionFurther evaluation of this condition is necessary in order to determine potential underlying aetiologies, pathophysiological mechanisms and the most appropriate standardised treatment.
Epidermal Growth Factor andEGFReceptors are mainly expressed in the wound epidermis and proliferating ependyma of the regenerating tail of lizards
Authors: Alibardi Lorenzo 
Published: December 2017

AbstractThe presence ofEGFand its receptor during tail regeneration in lizard has been assessed by immunoblotting and immunofluorescence to test whether this growth factor may be involved in the process. Immunolabelled bands at 8 and 42–46 kDa forEGFare detected in the regenerating tail. A main band at 45–50 kDa and other weaker bands at lower or higher molecular weight for theEGFreceptor are also present. The results indicate that degraded forms of the protein are present although the specific nature of the different bands could not be determined. Immunofluorescence indicates thatEGF‐labelled cells andEGFreceptor are especially seen in the wound epidermis and in the cytoplasm of ependymal cells. Numerous basal keratinocytes of the wound epidermis and apical epidermal peg contain labelled nuclei forEGFR, suggesting that activated receptor stimulates intense cell proliferation of the wound epidermis. Blastema and labelled myoblasts are occasionally detected in early differentiating muscles, but almost no labelled chondroblasts are present in the differentiating cartilaginous tube. The study indicates thatEGFand its receptor are mainly present in epithelial cells in a form that allows them to regulate proliferation during tail regeneration.
Superior anti‐suicidal effects of electroconvulsive therapy in unipolar disorder and bipolar depression
Authors: Liang Chih‐Sung , Chung Chi‐Hsiang , Ho Pei‐Shen , Tsai Chia‐Kuang , Chien Wu‐Chien 
Published: December 2017

ObjectivesElectroconvulsive therapy (ECT) has long been believed to reduce suicidal tendencies in patients with affective disorders; however, ECT recipients, who constitute the most severely ill and suicidal patients, are not eligible to participate in head‐to‐head randomized controlled trials. Large‐scale studies are required to investigate the anti‐suicidal effects of ECT vs psychopharmacotherapy.MethodsA nationwide retrospective cohort study design was used. Data were obtained from the Taiwan National Health Insurance Research Database. Inpatients with unipolar disorder or bipolar disorder who received ECT (n = 487) were observed from 1 January 2000 to 31 December 2013 for suicide events. The non‐ECT control cohort consisted of inpatients with psychopharmacotherapy randomly matched (ratio, 1:4) by age, sex, and diagnosis.ResultsAfter potential confounds had been accounted for, the adjusted hazard ratio (HR) was 0.803, indicating that ECT recipients showed a 19.7% lower risk of suicide than control individuals. The stratum‐specific adjusted HR was 0.79 in patients with unipolar disorder (P = .041) and 0.923 in patients with bipolar disorder (P = .254). Upon further stratification of the patients with bipolar disorder by their affective states, the adjusted HR was 0.805 (P = .046) for bipolar depression, 1.048 for bipolar mania (P = .538), and 0.976 for mixed bipolar state (P = .126).ConclusionsCompared with psychopharmacotherapy, ECT exerted superior anti‐suicidal effects in patients with unipolar disorder and bipolar depression; however, there was a lack of superior anti‐suicidal effects of ECT in the treatment of patients with bipolar mania and mixed state.
Which limb is it? Responses to vibrotactile stimulation in early infancy
Authors: Somogyi Eszter , Jacquey Lisa , Heed Tobias , Hoffmann Matej , Lockman Jeffrey J. , Granjon Lionel , Fagard Jacqueline , O'Regan J. Kevin 
Published: December 2017

This study focuses on how the body schema develops during the first months of life, by investigating infants’ motor responses to localized vibrotactile stimulation on their limbs. Vibrotactile stimulation was provided by small buzzers that were attached to the infants’ four limbs one at a time. Four age groups were compared cross‐sectionally (3‐, 4‐, 5‐, and 6‐month‐olds). We show that before they actually reach for the buzzer, which, according to previous studies, occurs around 7–8 months of age, infants demonstrate emerging knowledge about their body's configuration by producing specific movement patterns associated with the stimulated body area. At 3 months, infants responded with an increase in general activity when the buzzer was placed on the body, independently of the vibrator's location. Differentiated topographical awareness of the body seemed to appear around 5 months, with specific responses resulting from stimulation of the hands emerging first, followed by the differentiation of movement patterns associated with the stimulation of the feet. Qualitative analyses revealed specific movement types reliably associated with each stimulated location by 6 months of age, possibly preparing infants’ ability to actually reach for the vibrating target. We discuss this result in relation to newborns’ ability to learn specific movement patterns through intersensory contingency.Statement of contributionwhat is already known on infants’ sensorimotor knowledge about their own bodies3‐month‐olds readily learn to produce specific limb movements to obtain a desired effect (movement of a mobile).infants detect temporal and spatial correspondences between events involving their own body and visual events.what the present study addsuntil 4–5 months of age, infants mostly produce general motor responses to localized touch.this is because in the present study, infants could not rely on immediate contingent feedback.we propose a cephalocaudal developmental trend of topographic differentiation of body areas.
Phylogeny and the colourful history of jewel bugs (Insecta: Hemiptera: Scutelleridae)
Authors: Wu Yan‐Zhuo , Rédei Dávid , Eger Joseph , Wang Yan‐Hui , Wu Hao‐Yang , Carapezza Attilio , Kment Petr , Cai Bo , Sun Xiao‐Ya , Guo Peng‐Lei , Luo Jiu‐Yang , Xie Qiang 
Published: December 2017

AbstractMembers of the family Scutelleridae (Heteroptera: Pentatomomorpha: Pentatomoidea) are also called shield bugs because of the greatly enlarged scutellum, or jewel bugs because of the brilliant colours of many species. All scutellerids are phytophagous, feeding on various parts of their host plants. Due to lack of obvious synapomorphies and the failure to apply rigorous phylogenetic methods, the higher classification of Scutelleridae has been disputed for more than 150 years. Here we reconstructed a phylogeny of Scutelleridae based on complete sequences of 18S and 28S nuclear rDNAs and all 13 protein‐coding genes of the mitochondrial genome, with the sampled taxa covering all of the currently recognized subfamilies. The monophyly of Scutelleridae was confirmed by the congruence of the results of analyses conducted using Bayesian inference, maximum likelihood and maximum parsimony. The phylogenetic relationships among subfamilies were well resolved for the first time. Furthermore, time‐divergence studies estimated that the time of origin of Scutelleridae was in the Early Cretaceous (142.1–122.8 Ma), after the origin of the angiosperms. The diversification between the extant subfamilies of Scutelleridae and within the subfamilies occurred from the late Palaeocene to the late Miocene, simultaneously with the rise of the major groups of angiosperms and other phytophagous insects.
Cost‐effectiveness of bariatric surgery in adolescents with severe obesity in the UK
Authors: Panca M. , Viner R. M. , White B. , Pandya T. , Melo H. , Adamo M. , Batterham R. , Christie D. , Kinra S. , Morris S. 
Published: December 2017

SummaryEvidence shows that surgery for severe obesity in adults improves health and psychological functioning, and is cost‐effective. Data on bariatric surgery for adolescents with severe obesity are extremely limited, with no evidence on cost‐effectiveness. We evaluated the lifetime cost‐effectiveness of bariatric surgery compared with no surgery in adolescents with severe obesity from the UK's National Health Service perspective. Eighteen adolescents with body mass index ≥40 kg m−2 who underwent bariatric surgery (laparoscopic Roux en Y Gastric Bypass [RYGB] [N = 9], and laparoscopic Sleeve Gastrectomy [SG] [N = 9]) at University College London Hospitals between January 2008 and December 2013 were included. We used a Markov cohort model to compare the lifetime expected costs and quality‐adjusted life years (QALYs) between bariatric surgery and no surgery. Mean cost of RYGB and SG procedures were £7100 and £7312, respectively. For RYGB vs. no surgery, the incremental cost/QALY was £2018 (95% CI £1942 ‐ £2042) for males and £2005 (95% CI £1974 ‐ £2031) for females. For SG vs. no surgery, the incremental cost/QALY was £1978 (95% CI £1954 ‐ £2002) for males and £1941 (95% CI £1915 ‐ £1969) for females. Bariatric surgery in adolescents with severe obesity is cost‐effective; it is more costly than no surgery however it markedly improved quality of life.
Capacity‐oriented approaches to developing childhood obesity interventions: a systematic review
Authors: Foster B. A. , Fu E. , Bendiks N. , Gaspard C. S. , Sharifi M. 
Published: December 2017

SummaryCapacity‐oriented approaches to health interventions seek to empower the target population or community to manage the health issue themselves using resources they can control. Positive deviance, resilience and asset‐based approaches are three such methods of developing and implementing health interventions. This study aimed to review the efficacy of interventions explicitly applying these methods in addressing childhood obesity using adiposity as the primary outcome, measured by standardized body mass index. The search strategy was developed and implemented across four electronic databases. Of the 181 records identified and screened, 11 studies were identified as using a capacity‐oriented approach overall. Asset‐based approaches (n = 8 studies) consisted of 47 880 participants, positive deviance (n = 2 studies) consisted of 781 participants, and resilience‐based interventions (n = 1 study) consisted of 35 participants. The asset‐based approaches were mixed, with three of the eight studies showing a significant reduction in adiposity, while the other five did not find a difference. The positive deviance and resilience‐based studies showed signs of efficacy in reducing adiposity. There was significant design heterogeneity across studies, and varied interpretations and definitions of the approaches were used. Further work should attempt to achieve some consensus on the use of these approaches to facilitate comparison and advance the science of capacity‐oriented interventions for childhood obesity.
Long non‐coding PANDAR as a novel biomarker in human cancer: A systematic review
Authors: Zou Yifan , Zhong Yuantang , Wu Junjie , Xiao Huizhong , Zhang Xintao , Liao Xinhui , Li Jianfa , Mao Xuhua , Liu Yuchen , Zhang Fuyou 
Published: December 2017

AbstractObjectivesLong non‐coding RNAs (lncRNAs) are characterized as a group of RNAs that more than 200 nucleotides in length and have no protein‐coding function. More and more evidences provided that lncRNAs serve as key molecules in the development of cancer. Deregulation of lncRNAs functions as either oncogenes or tumour suppressor genes in various diseases. Recently, increasing studies about PANDAR in cancer progression were reported. In our review, we will focus on the current research on the character of PANDAR include the clinical management, tumour progression and molecular mechanisms in human cancers.Materials and methodsWe summarize and analyze current studies concerning the biological functions and mechanisms of lncRNA PANDA in tumour development. The related studies were obtained through a systematic search of Pubmed.ResultsPANDAR was a well‐characterized oncogenic lncRNA and widely overexpressed in many tumours. PANDAR is upregulated in many types of cancer, including colorectal cancer, lung cancer, renal cell carcinoma, cholangiocarcinoma, osteosarcoma, thyroid cancer and other cancers. Upregulation of PANDAR was significantly associated with advanced tumour weights, TNM stage and overall survival. Furthermore, repressed of PANDAR would restrain proliferation, migration and invasion.ConclusionPANDAR may act as a powerful tumour biomarker for cancer diagnosis and treatment.
The prevalence of asthma in Iranian adults: The first national survey and the most recent updates
Authors: Fazlollahi Mohammad Reza , Najmi Mehdi , Fallahnezhad Mojtaba , Sabetkish Nastaran , Kazemnejad Anoshirvan , Bidad Katayoon , Shokouhi Shoormasti Raheleh , Mahloujirad Maryam , Pourpak Zahra , Moin Mostafa 
Published: December 2017

AbstractBackgroundThe worldwide increase in the prevalence of asthma has made it a major public‐health concern. We aimed to identify the prevalence of asthma and asthma symptoms in adults living in urban and rural areas of Iran as a populated country with about 80 millions of residents.MethodsThis cross‐sectional study was conducted to estimate the prevalence of asthma in adults between 20 and 44 years old in all provinces of Iran. Data were collected by personal interview via a standardized questionnaire [European Community Respiratory Health Survey (ECRHS)] between November 2015 and February 2016.ResultsA total of 24 344 individuals were enrolled. The prevalence of asthma was 8.9% [95% confidence interval (CI): 8.5‐9.3]. The most common asthma symptoms were wheezing (14.2%, n = 3465), nocturnal cough (13.3%, n = 3234) and chest tightness (11.3%, n = 2760). Additionally, the prevalence of current asthma (taking asthma medications or asthma attack) was estimated to be 4.7% (n = 1155). Asthma was significantly more prevalent in males compared to females (P = .002), while no significant relationship was detected between gender and asthma after adjusted analysis with other variables. The prevalence of asthma was significantly higher in older participants (P < .001) and individuals with low educational level (P < .001). Interestingly, there was no significant relationship between asthma and area of residency (P = .8).ConclusionsThe prevalence of asthma in Iran was similar to other Asian and European countries. However, repeated national surveys are required to determine the trend of asthma prevalence in Iran in comparison to other countries.
Blood biomarkers as predictors of long‐term mortality in COPD
Authors: Mendy Angelico , Forno Erick , Niyonsenga Theophile , Gasana Janvier 
Published: December 2017

AbstractBackgroundBlood biomarkers are easily accessible and might reflect chronic obstructive pulmonary disease (COPD) activity.AimThe aim of this study was to determine whether a panel of blood biomarkers [C‐reactive protein (CRP), neutrophils, eosinophils, albumin and vitamin D] could predict mortality in COPD.MethodsWe analyzed data from 431 COPD participants to the 2007‐2010 National Health and Nutrition Examination Surveys who were followed for a median time of 36 months. COPD was defined as post‐bronchodilator forced expiratory volume in 1 second (FEV1) and forced vital capacity ratio <0.70. Weibull survival analysis adjusted for covariates was performed to calculate the risk of mortality associated with the biomarkers, and C‐statistics was used to assess their added predictive value.ResultsDuring follow‐up, 38 of the 431 participants died. Participants with high CRP, eosinophil count <2%, hypoalbuminemia and hypovitaminosis D had worse baseline FEV1 and subsequently higher mortality compared to controls. In adjusted analysis, increasing CRP [hazard ratio (HR): 4.45, 95% CI: 1.91‐10.37] and neutrophil count (HR: 1.07, 95% CI: 1.03‐1.11) as well as decreasing eosinophil count (HR: 7.03, 95% CI: 2.05‐24.01) were associated with an increased risk of mortality. The addition of CRP with eosinophil and/or neutrophil count significantly improved a base model for the prediction of mortality which included age, gender, race/ethnicity, body mass index, smoking, poverty income ratio, asthma, diabetes, hypertension and history of stroke or myocardial infarction.ConclusionHigh CRP and neutrophils as well as low eosinophils are predictive of poor COPD prognosis. They also add significant value to prediction models of mortality in COPD.