bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Benefits of Future Quantum Accelerometers for Satellite Gravimetry
Authors: Zingerle P. , Romeshkani M. , Haas J. , Gruber T. , Güntner A. , Müller J. , Pail R. 
Published: September 2024

AbstractWe investigate the benefits of future quantum accelerometers based on cold atom interferometry (CAI) on current and upcoming satellite gravity mission concepts. These mission concepts include satellite‐to‐satellite tracking (SST) in a single‐pair (GRACE‐like) and double‐pair constellation as well as satellite gravity gradiometry (SGG, single satellite, GOCE‐like). Regarding instruments, four scenarios are considered: current‐generation electrostatic (GRACE‐, GOCE‐like), next‐generation electrostatic, conservative hybrid/CAI and optimistic hybrid/CAI. For SST, it is shown that temporal aliasing poses currently the dominating error source in simulated global gravity field solutions independent of the investigated instrument and constellation. To still quantify the advantages of CAI instruments on the gravity functional itself, additional simulations are performed where the impact of temporal aliasing is synthetically reduced. When neglecting temporal aliasing, future accelerometers in conjunction with future ranging instruments can substantially improve the retrieval performance of the Earth's gravity field (depending on instrument and constellation). These simulation results are further investigated regarding possible benefit for hydrological use cases where these improvements can also be observed (when omitting temporal aliasing). For SGG, it is demonstrated that, with realistic instrument assumptions, one is still mostly insensitive to time‐variable gravity and not competitive with the SST principle. However, due to the improved instrument sensitivity of quantum gradiometers compared to the GOCE mission, static gravity field solutions can be improved significantly.
On the Love Numbers of an Andrade Planet
Authors: Consorzi Anastasia , Melini Daniele , González‐Santander Juan Luis , Spada Giorgio 
Published: September 2024

AbstractThe Andrade rheological model is often employed to describe the response of solar system or extra‐solar planets to tidal perturbations, especially when their properties are still poorly constrained. While for uniform planets with steady‐state Maxwell rheology the analytical form of the Love numbers was established long ago, for the transient Andrade rheology no closed‐form solutions have been yet determined, and the planetary response is usually studied either semi‐analitically in the frequency domain or numerically in the time domain. Closed‐form expressions are potentially important since they could provide insight into the dependence of Love numbers upon the model parameters and the time‐scales of the isostatic readjustment of the planet. First, we focus on the Andrade rheological law in 1‐D and we obtain a previously unknown explicit form, in the time domain, for the relaxation modulus in terms of the higher Mittag‐Leffler transcendental function Eα,β(z) that generalizes the exponential function. Second, we consider the general response of an incompressible planetary model — often referred to as the “Kelvin sphere” — studying the Laplace domain, the frequency domain and the time domain Love numbers by analytical methods. Through a numerical approach, we assess the effect of compressibility on the Love numbers in the Laplace and frequency domains. Furthermore, exploiting the results obtained in the 1‐D case, we establish closed‐form — although not elementary — expressions of the time domain Love numbers and we discuss the frequency domain response of the Kelvin sphere with Andrade rheology analytically.
Global Assessment of Compound Climate Extremes and Exposures of Population, Agriculture, and Forest Lands Under Two Climate Scenarios
Authors: Schillerberg Tayler A. , Tian Di 
Published: September 2024

AbstractClimate change is expected to increase the global occurrence and intensity of heatwaves, extreme precipitation, and flash droughts. However, it is not well understood how the compound heatwave, extreme precipitation, and flash drought events will likely change, and how global population, agriculture, and forest will likely be exposed to these compound events under future climate change scenarios. This research uses eight CMIP6 climate models to assess the current and future global compound climate extreme events, as well as population, agriculture, and forestry exposures to these events, under two climate scenarios, Shared Socioeconomic Pathways (SSP), SSP1‐2.6 and SSP5‐8.5 for three time periods: early‐, mid‐, and late‐ 21st century. Climate extremes are derived for heatwaves, extreme precipitation, and flash droughts using locational‐dependent thresholds. We find that compound heatwaves and flash drought events result in the largest increases in exposure of populations, agriculture, and forest lands, under SSP5‐8.5 late‐century projections of sequential heatwaves and flash droughts. Late‐century projections of sequential heatwaves and flash droughts show hot spots of exposure increases in population exposure greater than 50 million person‐events in China, India, and Europe; increases in agriculture land exposures greater than 90 thousand km2‐events in China, South America, and Oceania; and increase in forest land exposure greater than 120 thousand km2‐events in Oceania and South America regions when compared to the historical period. The findings from this study can be potentially useful for informing global climate adaptations.
Beyond Hydrology: Exploring the Factors Influencing the Seasonal Variation of the Molecular Composition of Riverine Dissolved Organic Matter
Authors: Zhan Xiaoqian , Bao Hongyan , Niggemann Jutta , Zhao Weiqiang , Chen Nengwang , Huang Dekun , Du Moge , Yi Yuanbi , Dittmar Thorsten , Kao Shuh‐Ji 
Published: September 2024

AbstractThe export of dissolved organic matter (DOM) from rivers is essential for linking terrestrial and marine carbon reservoirs in the global carbon cycle. However, there is limited knowledge regarding how the molecular composition of riverine DOM changes under different hydrological conditions, especially during extreme rainfall events. Moreover, the factors beyond hydrology that impact DOM composition have not been well defined. To address these gaps, samples were collected from a human‐impacted medium‐sized subtropical monsoonal river across various hydrological conditions throughout a complete hydrological cycle. Utilizing high‐resolution mass spectrometry, it was discovered that the solid‐phase extractable DOM (SPE‐DOM) during the high‐flow (1 < runoff (Q): annual mean runoff (Qm) < 3) and extreme‐rain (Q:Qm > 3) periods exhibited a higher number of molecular formulae, lower H/C, higher O/C, and a higher proportion of carboxylic‐rich alicyclic molecules compared to the low‐flow period (LFP) (Q:Qm < 1). These alterations were attributed to input from more diverse sources, particularly a greater input from soil organic matter with higher oxidation degrees. Additionally, the P‐containing formulae were more enriched during the extreme‐rain period, likely from agricultural lands and sediment release. Conversely, the fraction of S‐containing formulae was significantly higher during the LFP, possibly due to the amplified influence of anthropogenic input. Furthermore, the DOM aromaticity did not fluctuate with runoff but was significantly associated with temperature. In summary, the study indicated that the composition of DOM varied significantly under different hydrological conditions, with temperature and anthropogenic activities identified as crucial factors influencing riverine DOM export.
Star wars against leukemia: attacking the clones
Authors: Toma Monika M. , Skorski Tomasz 
Published: September 2024

AbstractLeukemia, although most likely starts as a monoclonal genetic/epigenetic anomaly, is a polyclonal disease at manifestation. This polyclonal nature results from ongoing evolutionary changes in the genome/epigenome of leukemia cells to promote their survival and proliferation advantages. We discuss here how genetic and/or epigenetic aberrations alter intracellular microenvironment in individual leukemia clones and how extracellular microenvironment selects the best fitted clones. This dynamic polyclonal composition of leukemia makes designing an effective therapy a challenging task especially because individual leukemia clones often display substantial differences in response to treatment. Here, we discuss novel therapeutic approach employing single cell multiomics to identify and eradicate all individual clones in a patient.
Deep learning-based virtual staining, segmentation, and classification in label-free photoacoustic histology of human specimens
Authors: Yoon Chiho , Park Eunwoo , Misra Sampa , Kim Jin Young , Baik Jin Woo , Kim Kwang Gi , Jung Chan Kwon , Kim Chulhong 
Published: September 2024

AbstractIn pathological diagnostics, histological images highlight the oncological features of excised specimens, but they require laborious and costly staining procedures. Despite recent innovations in label-free microscopy that simplify complex staining procedures, technical limitations and inadequate histological visualization are still problems in clinical settings. Here, we demonstrate an interconnected deep learning (DL)-based framework for performing automated virtual staining, segmentation, and classification in label-free photoacoustic histology (PAH) of human specimens. The framework comprises three components: (1) an explainable contrastive unpaired translation (E-CUT) method for virtual H&E (VHE) staining, (2) an U-net architecture for feature segmentation, and (3) a DL-based stepwise feature fusion method (StepFF) for classification. The framework demonstrates promising performance at each step of its application to human liver cancers. In virtual staining, the E-CUT preserves the morphological aspects of the cell nucleus and cytoplasm, making VHE images highly similar to real H&E ones. In segmentation, various features (e.g., the cell area, number of cells, and the distance between cell nuclei) have been successfully segmented in VHE images. Finally, by using deep feature vectors from PAH, VHE, and segmented images, StepFF has achieved a 98.00% classification accuracy, compared to the 94.80% accuracy of conventional PAH classification. In particular, StepFF’s classification reached a sensitivity of 100% based on the evaluation of three pathologists, demonstrating its applicability in real clinical settings. This series of DL methods for label-free PAH has great potential as a practical clinical strategy for digital pathology.
Enhanced high harmonic efficiency through phonon-assisted photodoping effect
Authors: Zhang Jin , Neufeld Ofer , Tancogne-Dejean Nicolas , Lu I-Te , Hübener Hannes , De Giovannini Umberto , Rubio Angel 
Published: September 2024

AbstractHigh-harmonic generation (HHG) has emerged as a central technique in attosecond science and strong-field physics, providing a tool for investigating ultrafast dynamics. However, the microscopic mechanism of HHG in solids is still under debate, and it is unclear how it is modified in the ubiquitous presence of phonons. Here we theoretically investigate the role of collectively coherent vibrations in HHG in a wide range of solids (e.g., hBN, graphite, 2H-MoS2, and diamond). We predict that phonon-assisted high harmonic yields can be significantly enhanced, compared to the phonon-free case – up to a factor of ~20 for a transverse optical phonon in bulk hBN. We also show that the emitted harmonics strongly depend on the character of the pumped vibrational modes. Through state-of-the-art ab initio calculations, we elucidate the physical origin of the HHG yield enhancement – phonon-assisted photoinduced carrier doping, which plays a paramount role in both intraband and interband electron dynamics. Our research illuminates a clear pathway toward comprehending phonon-mediated nonlinear optical processes within materials, offering a powerful tool to deliberately engineer and govern solid-state high harmonics.
Role of reactive transport in the alteration of vitrified waste packages: the MOS model
Authors: Frugier Pierre , Godon Nicole , Minet Yves 
Published: September 2024

AbstractThe MOS model (acronym coming from the French MOdèle Simplifié) was born from the desire to have a simple tool that can quantify the contribution of the diffusive reactive environment to the alteration of a vitrified nuclear waste package in deep geological disposal conditions. In the model, this environmental contribution consists partly of the ability of iron, metallic casing corrosion products, and argillite to consume silicon, and partly of the brake on diffusive transport provided by silicon through the successive layers of environmental material. It is a modeling tool serving as an intermediary between operational modeling for the calculation of the source term from the glass, mathematically more simple and giving higher upper margins, and models that use geochemistry and transport, giving greater accuracy for the interactions between glass and its environment. The goal of the MOS model is to calculate the possible impact of silicon reactive diffusion on the alteration rate within the different layers of material surrounding nuclear glass. This article lists the simplifying hypotheses on which the MOS is based, presents the digital resolution method for an environment consisting of several successive layers with different reactivity and transport properties, and explains the model’s implementation.
Seismic analysis of Islamic Egyptian minarets through 3D scanning and dynamic simulation
Authors: Abdel-Wahab A. M. , Badawy Amr H. , El-Feky M. S. 
Published: September 2024

AbstractRecently, Egypt had seismic activity. These seismic events have affected the stability of minarets, especially historical ones. Weight is one of the minaret's main stability factors. The main objective of the current research is to perform a three-dimensional (3D) assessment of an existing minaret, determine its accurate spatial model, document its current condition, examine its stability in the event of earthquakes, and identify the requisite measures to safeguard the minaret from any potential damage. The masonry to construct the minaret was used by extracting and examining specimens of this substance to determine its physical characteristics. The current work created three-dimensional models of the Abou-Ghanam El-Bialy minaret using a terrestrial laser scanner (TLS) to document its current condition, as well as minaret was subjected to a free vibration analysis using 3D finite element modeling. Finally, the minaret's seismic behavior was assessed utilizing mode forms, base responses, and normal stresses. The surveying method effectively documented the Minarets' existing case. The 3D seismic analysis showed that the minaret responded dynamically to earthquake loading, with mode shapes, base reactions, and normal stresses being crucial characteristics. Based on these data, we may suggest procedures to protect the minaret during seismic events.
Choline chloride and amino acid solutions taste and hydration behavior with experimental thermodynamic properties and COSMO-PC-SAFT calculation
Authors: Morsali Mohammad Amin , Golmohammadi Behrang , Shekaari Hemayat 
Published: September 2024

AbstractAqueous amino acid solutions have been introduced as dietary supplements for both animals and humans. This study investigates the physicochemical properties of the solutions containing amino acids (l-glycine, d,l-alanine, l-proline), choline chloride, and water at temperature range of 288.15 to 318.15 K. The results show that increasing concentrations of amino acids and choline chloride lead to higher solution densities. Analysis of apparent molar volume (Vφ) and apparent molar isentropic compressibility (κφ) reveals that Vφ values increase with choline chloride concentration and temperature, indicating enhanced solute–solvent interactions, while κφ values decrease, suggesting increased solution compression. Thermodynamic analysis using the Redlich-Mayer model and COSMO-based modeling provides insights into molecular interactions. However, COSMO-based parameters show high average relative deviation percentage (ARD %) values, indicating poor predictive performance for the density of these systems. In contrast, the ePC-SAFT equation of state effectively predicts the densities, particularly for l-proline-based solutions, which show very low ARD % values, indicating high accuracy. The ePC-SAFT model also performs reasonably well for l-glycine solutions but shows poorer results for d,l-alanine-based solutions. The study also examines the sweetness and saltiness criteria (ASV and ASIC) of these solutions. The ASV values, which serve as a sweetness criterion, are higher than the ideal range of 0.5 < ASV < 0.7, suggesting an overly sweet taste. The ASIC values follow a similar trend, indicating increased saltiness. To achieve an appropriate grade of sweetness and saltiness, dilution to lower concentrations of the solution is recommended. Furthermore, the use of choline chloride is found to increase salt intake and enhance the taste of salt, which can be beneficial in amino acid supplements used in animal food.
T-cell responses to ancestral SARS-CoV-2 and Omicron variant among unvaccinated pregnant and postpartum women living with and without HIV in South Africa
Authors: McMahon William C. , Kwatra Gaurav , Izu Alane , Jones Stephanie A. , Mbele Nkululeko J. , Jafta Nwabisa , Lala Rushil , Shalekoff Sharon , Tiemessen Caroline T. , Madhi Shabir A. , Nunes Marta C. 
Published: September 2024

AbstractSARS-CoV-2 cell-mediated immunity remains understudied during pregnancy in unvaccinated Black African women living with HIV (WLWH) from low- and middle-income countries. We investigated SARS-CoV-2-specific T-cell responses 1 month following infection in 24 HIV-uninfected women and 15 WLWH at any stage during pregnancy or postpartum. The full-length spike (FLS) glycoprotein and nucleocapsid (N) protein of wild-type (WT) SARS-CoV-2, as well as mutated spike protein regions found in the Omicron variant (B.1.1.529) were targeted by flow cytometry. WT-specific CD4+ and CD8+ T cells elicited similar FLS- and N-specific responses in HIV-uninfected women and WLWH. SARS-CoV-2-specific T-lymphocytes were predominantly TNF-α monofunctional in pregnant and postpartum women living with and without HIV, with fever cells producing either IFN-γ or IL-2. Furthermore, T-cell responses were unaffected by Omicron-specific spike mutations as similar responses between Omicron and the ancestral virus were detected for CD4+ and CD8+ T cells. Our results collectively demonstrate comparable T-cell responses between WLWH on antiretroviral therapy and HIV-uninfected pregnant and postpartum women who were naïve to Covid-19 vaccination. Additionally, we show that T cells from women infected with the ancestral virus, Beta variant (B.1.351), or Delta variant (B.1.617.2) can cross-recognize Omicron, suggesting an overall preservation of T-cell immunity.
Satellite DNAs and the evolution of the multiple X1X2Y sex chromosomes in the wolf fish Hoplias malabaricus (Teleostei; Characiformes)
Authors: Toma Gustavo Akira , Sember Alexandr , Goes Caio Augusto Gomes , Kretschmer Rafael , Porto-Foresti Fabio , Bertollo Luiz Antônio Carlos , Liehr Thomas , Utsunomia Ricardo , de Bello Cioffi Marcelo 
Published: September 2024

AbstractMultiple sex chromosomes usually arise from chromosomal rearrangements which involve ancestral sex chromosomes. There is a fundamental condition to be met for their long-term fixation: the meiosis must function, leading to the stability of the emerged system, mainly concerning the segregation of the sex multivalent. Here, we sought to analyze the degree of differentiation and meiotic pairing properties in the selected fish multiple sex chromosome system present in the wolf-fish Hoplias malabaricus (HMA). This species complex encompasses seven known karyotype forms (karyomorphs) where the karyomorph C (HMA-C) exhibits a nascent XY sex chromosomes from which the multiple X1X2Y system evolved in karyomorph HMA-D via a Y-autosome fusion. We combined genomic and cytogenetic approaches to analyze the satellite DNA (satDNA) content in the genome of HMA-D karyomorph and to investigate its potential contribution to X1X2Y sex chromosome differentiation. We revealed 56 satDNA monomers of which the majority was AT-rich and with repeat units longer than 100 bp. Seven out of 18 satDNA families chosen for chromosomal mapping by fluorescence in situ hybridization (FISH) formed detectable accumulation in at least one of the three sex chromosomes (X1, X2 and neo-Y). Nine satDNA monomers showed only two hybridization signals limited to HMA-D autosomes, and the two remaining ones provided no visible FISH signals. Out of seven satDNAs located on the HMA-D sex chromosomes, five mapped also to XY chromosomes of HMA-C. We showed that after the autosome-Y fusion event, the neo-Y chromosome has not substantially accumulated or eliminated satDNA sequences except for minor changes in the centromere-proximal region. Finally, based on the obtained FISHpatterns, we speculate on the possible contribution of satDNA to sex trivalent pairing and segregation.
Green synthesis of copper oxide nanoparticles using walnut shell and their size dependent anticancer effects on breast and colorectal cancer cell lines
Authors: Abdollahzadeh Hanieh , Pazhang Yaghub , Zamani Asghar , Sharafi Yousef 
Published: September 2024

AbstractMetal oxide nanoparticles(NPs) contain unique properties which have made them attractive agents in cancer treatment. The CuO nanoparticles were green synthesized using walnut shell powder in different calcination temperatures (400°, 500°, 700°, and 900 °C). The CuO nanoparticles are characterized by FTIR, XRD, BET, SEM and DLS analyses. SEM and DLS analyses showed that by increasing the required calcination temperature for synthesizing the NPs, their size was increased. DPPH analysis displayed no significant anti-oxidative properties of the CuO NPs. The MTT analysis showed that all synthesized CuO NPs exhibited cytotoxic effects on MCF-7, HCT-116, and HEK-293 cell lines. Among the CuO NPs, the CuO-900 NPs showed the least cytotoxic effect on the HEK-293 cell line (IC50 = 330.8 µg/ml). Hoechst staining and real-time analysis suggested that the CuO-900 NPs induced apoptosis by elevation of p53 and Bax genes expression levels. Also, the CuO-900 NPs increased the Nrf-2 gene expression level in MCF-7 cells, despite the HCT-116 cells. As can be concluded from the results, the CuO-900 NPs exerted promising cytotoxic effects on breast and colon cancer cells.
Nano-micro pore structure characteristics of carbon black and recycled carbon fiber reinforced alkali-activated materials
Authors: Zhang Weiwei , Yin Binbin , Akbar Arslan , Li Wen-Wei , Dai Yitao , Liew K. M. 
Published: September 2024

AbstractMicroscopic scrutiny aids in alkali-activated materials’ (AAM) application in construction industry. This study delves into the pore structure and properties of one-part alkali-activated slag (AAS) mortar modified by carbon black (CB) and recycled carbon fiber (rCF). The additives enhanced flexural strength by 51.82% (12.16 MPa) with lower water absorption (10.24%). Refinement of pore size and reduction of connectivity are key factors in improving properties. The densification effect of CB and the strong interface between rCF and gel were observed. Furthermore, AAS mortars exhibited multifractal characteristics within the range of micropores and capillary pores. Despite altering fractal regions, the additives did not affect its size dependence. The backbone fractal dimension increases with the addition of CB and rCF, exhibiting strong correlations with various macro properties, thus serving as a comprehensive parameter to characterize pore shape and distribution. This study deepens understanding of AAM composites, facilitating their adoption of low-carbon building materials.