bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study
Authors: Ng Jia Hui , Iyer N. Gopalakrishna , Tan Min‐Han , Edgren Gustaf 
Published: October 2016

ABSTRACTBackgroundThere are reports about the changing epidemiology of tongue squamous cell carcinoma (SCC), with recent reports indicating an increasing incidence in young women.MethodsData on incident cases of tongue SCC were collected from cancer registries worldwide.ResultsData from a total of 22 cancer registries and 89,212 incident cases of tongue SCC worldwide were included. Most areas experienced an incidence increase ranging from 0.4% to 3.3% per year. There was a significant difference in the incidence increase between sexes in 11 of the 22 registries. In 14 of the 22 registries studied, the increase in incidence of tongue SCC was higher in the group of subjects <45 years old than those ≥45 years old.ConclusionThis study suggests a general but not universal increase in the incidence of tongue SCC worldwide. In some regions of the world, we observed a shifting trend toward women and/or younger patients. © 2016 Wiley Periodicals, Inc. Head Neck 39: 297–304, 2017
Pretreatment with β‐adrenergic receptor agonists facilitates induction of LTP and sharp wave ripple complexes in rodent hippocampus
Authors: ul Haq Rizwan , Anderson Marlene , Liotta Agustin , Shafiq Maria , Sherkheli Muhammad Azhar , Heinemann Uwe 
Published: October 2016

ABSTRACTNorepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre‐ and post‐synaptic adrenergic receptors. Here we show that β‐agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW‐Rs) in acute slices of rat hippocampus in area CA3. Surprisingly, this facilitating effect persists when slices are only pretreated with β‐receptor agonists followed by wash out and application of the unspecific β‐adrenoreceptor (βAR) antagonist propranolol. During application of βAR agonists repeated stimulation resulted in facilitated induction of SPW‐Rs. Since SPW‐Rs are thought to be involved in memory replay we studied the effects of βAR‐agonists on spontaneous SPW‐Rs in murine hippocampus and found that amplitude and incidence of SPW‐Rs increased. These effects involve cyclic‐AMP and the activation of protein kinase A and suggest a supportive role in memory consolidation. © 2016 Wiley Periodicals, Inc.
Inhibition of SLC7A11 by Sulfasalazine Enhances Osteogenic Differentiation of Mesenchymal Stem Cells by Modulating BMP2/4 Expression and Suppresses Bone Loss in Ovariectomized Mice
Authors: Jin Chanyuan , Zhang Ping , Zhang Min , Zhang Xiao , Lv Longwei , Liu Hao , Liu Yunsong , Zhou Yongsheng 
Published: October 2016

ABSTRACT

An imbalance in osteogenesis and adipogenesis is a crucial pathological factor in the development of osteoporosis. Many attempts have been made to develop drugs to prevent and treat this disease. In the present study, we investigated the phenomenon whereby downregulation of SLC7A11 significantly enhanced the osteogenic differentiation of mesenchymal stem cells (MSCs) in vitro, and promoted the bone formation in vivo. Sulfasalazine (SAS), an inhibitor of SLC7A11, increased the osteogenic potential effectively. Mechanistically, inhibition of SLC7A11 by SAS treatment or knockdown of SLC7A11 increased BMP2/4 expression dramatically. In addition, we detected increased Slc7a11 expression in bone marrow MSCs of ovariectomized (OVX) mice. Remarkably, SAS treatment attenuated bone loss in ovariectomized mice. Together, our data suggested that SAS could be used to treat osteoporosis by enhancing osteogenic differentiation of MSCs. © 2016 American Society for Bone and Mineral Research.
Exploring Divergent Patterns in Racial Identity Profiles Between Caribbean Black American and African American Adolescents: The Links to Perceived Discrimination and Psychological Concerns
Authors: Sanchez Delida , Bentley‐Edwards Keisha L. , Matthews J. S. , Granillo Teresa 
Published: October 2016

Using cluster analyses, this study explored the relations among racial identity, perceived discrimination, and psychological concerns among 189 Caribbean Black American and African American adolescents. Findings showed that for all participants, less mature racial identity profiles were significantly related to perceived discrimination and psychological concerns. However, nuances in racial identity profiles between Caribbean Black American and African American participants suggest subtle ethnic group differences in racial identity development. Implications for practitioners and research are discussed.Usando análisis cluster, este estudio exploró las relaciones entre identidad racial, discriminación percibida y preocupaciones psicológicas en 189 adolescentes afroamericanos y americanos negros caribeños. Los hallazgos mostraron que, para todos los participantes, los perfiles de identidad racial menos maduros estaban significativamente relacionados con una discriminación percibida y preocupaciones psicológicas. Sin embargo, los matices de los perfiles de identidad racial entre los participantes afroamericanos y americanos negros caribeños sugieren unas diferencias sutiles entre ambos grupos étnicos en el desarrollo de la identidad racial. Se discuten las implicaciones para practicantes e investigadores.
Transglutaminase‐catalyzed amination of pea protein peptides using the biogenic amines histamine and tyramine
Authors: Lu Xinyao , Hrynets Yuliya , Betti Mirko 
Published: October 2016

AbstractBACKGROUNDBiogenic amines (BAs) are produced by the enzymatic decarboxylation of amino acids, and are well‐known for their toxicity to humans. This study describes a new method using microbial transglutaminase (MTGase) to covalently link BAs such as histamine (HIS) and tyramine (TYR) to the glutamine residues of alcalase‐hydrolyzed pea protein (PPH).RESULTSThe incubation of PPH and HIS and TYR in the presence of MTGase at 37 °C led to the formation of conjugates, as determined by liquid chromatography, after derivatization with dansyl chloride. Seventy‐six % of HIS and 65% of TYR were covalently incorporated to PPH by MTGase. The incubation of PPH and TYR in the presence of MTGase exhibited a 52% DPPH radical scavenging activity at 10 mg mL−1. Conjugation via MTGase improved the antioxidant status by reducing lipid peroxidation.CONCLUSIONThis study emphasizes that the application of MTGase can effectively reduce histamine and tyramine content while simultaneously enhancing antioxidative capacity of PPH. © 2016 Society of Chemical Industry
Yeast and bacteria from ensiled high moisture maize grains as potential mitigation agents of fumonisin B1
Authors: Martinez Tuppia Ccori , Atanasova‐Penichon Vessela , Chéreau Sylvain , Ferrer Nathalie , Marchegay Gisèle , Savoie Jean‐Michel , Richard‐Forget Florence 
Published: October 2016

AbstractBACKGROUNDFumonisin B1 (FB1) is a mycotoxin produced by several Fusarium species and is a very common contaminant of maize‐based food and feed throughout the world. The selection and use of FB1‐degrading microorganisms appears as a promising alternative to cope with the problem of toxicity towards humans and livestock. High moisture maize grain silage, which is based on natural maize fermentation, could be an interesting reservoir of such microorganisms.RESULTSUsing an in vitro simulated silage model with FB1 naturally contaminated grains, we demonstrated a significant raw decrease in FB1 during ensiling process ascribed to biodegradation mechanisms. A panel of 98 bacteria and yeasts were isolated from this matrix and selected for their ability to use FB1 as the sole source of C and N. For nine of them, the ability to degrade FB1 in vitro was evidenced. Notably, two bacteria identified as Lactobacillus sp. were highlighted for their efficient FB1‐degrading capacity and production of hydrolysed FB1 as intermediate degradation metabolite.CONCLUSIONFermentation of high moisture maize grain contaminated with FB1 leads to a significant reduction of the toxin and allows the isolation of FB1‐degrading microorganisms that could further be used as FB1 decontaminating agents. © 2016 Society of Chemical Industry
Impact of a novel synbiotic supplementation during gestation and lactation on immune responses in the Swiss albino mice offspring
Authors: Nallagatla Himaja , Hemalatha Rajkumar , Kondapalli Narendra Babu , Mohammed Shujauddin 
Published: October 2016

AbstractBACKGROUNDPrebiotics from various regularly consumed cereals and novel substrates are currently being utilised as functional foods. The aim of this study was to determine the effect of synbiotic, formulated with prebiotic extracted from natural resources like green gram (Vigna radiata) along with probiotic Lactobacillus rhamnosus GG (LGG) in modulating immune responses in the offspring when supplemented during gestation and lactation.RESULTSSynbiotic supplementation was effective in improving cell mediated immunity and humoral immunity among F0 dams. Among F1 pups (F1 Syn + and F1 Syn−), synbiotic supplementation showed significantly heightened (P < 0.05) splenocyte proliferation, increased interleukin‐10, interferon gamma and interleukin‐17 responses, leucocyte phagocytic ability and increased secretory‐immunoglobulin A. However, four‐fold increase in IgG titres to Hepatitis‐B vaccine was observed only in those mice that were supplemented with synbiotic postweaning (F1 Syn+).CONCLUSIONSynbiotic supplementation to pregnant dams affected the offspring's cellular and mucosal immunity favorably. However, IgG response to Hepatitis‐B vaccine was influenced positively only when the supplementation was extended to the offsprings in the post weaning period. © 2016 Society of Chemical Industry
Proteomic analysis of peel browning of ‘Nanguo’ pears after low‐temperature storage
Authors: Wang Jun‐wei , Zhou Xin , Zhou Qian , Liu Zhi‐yong , Sheng Lei , Wang Long , Cheng Shun‐chang , Ji Shu‐juan 
Published: October 2016

AbstractBACKGROUNDPostharvest ripening of the ‘Nanguo’ pear (Pyrus ussuriensis Maxim.) can be impeded by low‐temperature storage. However, pears after long‐term refrigeration are prone to peel browning when returned to room temperature conditions. This study investigated the browning mechanism of ‘Nanguo’ pear stored at a low temperature by analysing the differentially expressed proteins between healthy fruit and fruit with peel browning.RESULTSThe results showed that 181 proteins underwent statistically significant changes. A categorisation of the disparately accumulated proteins was performed using gene ontology annotation. The results showed that the ‘metabolic process’, ‘cellular process’, ‘catalytic activity’, and ‘binding’ proteins were the most affected after low‐temperature storage. Further analysis revealed that the differentially expressed proteins, which are related to peel browning, are primarily involved in the phenylpropanoid pathway, linoleic acid pathways, fatty acid biosynthesis pathway, glutathione metabolism pathway, photosynthesis pathway, oxidative phosphorylation pathway, and glycolysis pathway.CONCLUSIONThis study reveals that there are variations in key proteins in ‘Nanguo’ pear after low‐temperature storage, and the identification of these proteins will be valuable in future functional genomics studies, as well as provide protein resources that can be used in the efforts to improve pear quality. © 2016 Society of Chemical Industry
The Influence of Organic Carbon and pH on Heavy Metals, Potassium, and Magnesium Levels in Lithuanian Podzols
Authors: Khaledian Yones , Pereira Paulo , Brevik Eric C. , Pundyte Neringa , Paliulis Dainius 
Published: October 2016

AbstractIndustrial activities can contribute to the accumulation of heavy metals in soils, which could potentially threaten public health and the environment. This research was conducted to investigate the relationships between pH and total organic carbon (TOC) with soil chemical parameters, including exchangeable and total Cu, Zn, Cd, Pb, K, and Mg concentrations in soils near Panevėžys and Kaunas, Lithuania. Principal component regression (PCR) and non‐linear regression were used to find statistical relationships between pH, TOC, and the other soil properties studied. The results of correlation tests indicated that pH and TOC had strong relationships with most of the soil properties. The results of PCR [R2 = 0·87, RMSE = 0·046] and non‐linear regression [R2 = 0·91, RMSE = 0·041] (pH and the entire parameters), PCR [R2 = 0·777, RMSE = 0·058] and non‐linear regression [R2 = 0·871, RMSE = 0·046] (pH and the exchangeable parameters) to model the relationships between pH and soil chemical properties were promising and significant. Exchangeable heavy metal concentrations increased for pH > 5. Even though the relationships between TOC and heavy metals were significant, they were not as powerful as the relationships between pH and these metals. It was concluded that total metal concentrations in the study soils can be predicted by either pH or TOC. Metal mobility could most likely be controlled at the study site by manipulating soil pH and/or TOC. Finally, it is suggested that when there are financial and time limitations, assessment of total exchangeable metal concentrations using soil pH and/or TOC could be productive. Copyright © 2016 John Wiley & Sons, Ltd.
Metamaterial absorber integrated microfluidic terahertz sensors
Authors: Hu Xin , Xu Gaiqi , Wen Long , Wang Huacun , Zhao Yuncheng , Zhang Yaxin , Cumming David R. S. , Chen Qin 
Published: October 2016

AbstractSpatial overlap between the electromagnetic fields and the analytes is a key factor for strong light‐matter interaction leading to high sensitivity for label‐free refractive index sensing. Usually, the overlap and therefore the sensitivity are limited by either the localized near field of plasmonic antennas or the decayed resonant mode outside the cavity applied to monitor the refractive index variation. In this paper, by constructing a metal microstructure array‐dielectric‐metal (MDM) structure, a novel metamaterial absorber integrated microfluidic (MAIM) sensor is proposed and demonstrated in terahertz (THz) range, where the dielectric layer of the MDM structure is hollow and acts as the microfluidic channel. Tuning the electromagnetic parameters of metamaterial absorber, greatly confined electromagnetic fields can be obtained in the channel resulting in significantly enhanced interaction between the analytes and the THz wave. A high sensitivity of 3.5 THz/RIU is predicted. The experimental results of devices working around 1 THz agree with the simulation ones well. The proposed idea to integrate metamaterial and microfluid with a large light‐matter interaction can be extended to other frequency regions and has promising applications in matter detection and biosensing.
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3D in utero quantification of T2* relaxation times in human fetal brain tissues for age optimized structural and functional MRI
Authors: Blazejewska Anna I. , Seshamani Sharmishtaa , McKown Susan K. , Caucutt Jason S. , Dighe Manjiri , Gatenby Christopher , Studholme Colin 
Published: October 2016

PurposeMaximization of the blood oxygen level–dependent (BOLD) functional MRI (fMRI) contrast requires the echo time of the MR sequence to match the T2* value of the tissue of interest, which is expected to be higher in the fetal brain compared with the brain of a child or an adult.MethodsT2* values of the cortical plate/cortical gray matter tissue in utero in healthy fetuses from mid‐gestation onward (20–36 gestational weeks) were measured using 3D T2* maps calculated from 2D dual‐echo T2*‐weighted data corrected for between‐slice motion and reconstructed in 1.0 mm3 isotropic resolution from a sequence of multiple time points, together with 1.0 mm3 isotropic resolution T2‐weighted structural data.ResultsMean T2* relaxation times of the cortical tissue were about twice as high as those reported previously in adults. In a supporting experiment applying single seed analysis, default mode and auditory networks appeared better localized and less noisy while using an echo time of 100 ms versus 43 ms. The results of the previous study reporting a trend for T2* values to decrease with fetal age were reproduced and extended to include cortical tissues and subjects in earlier gestation (20–26 gestational weeks).ConclusionThe first measurement of T2* values in fetal cortical tissues suggested the appropriate echo time range for fetal BOLD fMRI protocol optimization to be 130–190 ms. Magn Reson Med 78:909–916, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Susceptibility underestimation in a high‐susceptibility phantom: Dependence on imaging resolution, magnitude contrast, and other parameters
Authors: Zhou Dong , Cho Junghun , Zhang Jingwei , Spincemaille Pascal , Wang Yi 
Published: October 2016

PurposeWe assessed the accuracy of quantitative susceptibility mapping in a gadolinium balloon phantom with a large range of susceptibility values and imaging resolutions at 1.5 and 3 Tesla (T).Theory and MethodsThe phantom contained sources with susceptibility values of 0.4, 0.8, 1.6, and 3.2 ppm and was imaged at isotropic resolutions of 0.7, 0.8, 1.2, and 1.8 mm. Numerical simulations were performed to match the experimental findings. Voxel sensitivity effects were used to explain the susceptibility underestimations.ResultsBoth phantom data and simulation demonstrated that systematic underestimation of the susceptibility values increased with voxel size, field strength, and object susceptibility.ConclusionThe underestimation originates from the signal formation in a voxel, which can be described by the voxel sensitivity function. The amount of underestimation is thus affected by imaging resolution, magnitude contrast, image filtering, and details of the susceptibility inclusions such as the susceptibility value and geometry. High‐resolution imaging is therefore needed for accurate reconstruction of QSM values, especially at higher susceptibilities. Magn Reson Med 78:1080–1086, 2017. © 2016 International Society for Magnetic Resonance in Medicine
A rapid and robust gradient measurement technique using dynamic single‐point imaging
Authors: Jang Hyungseok , McMillan Alan B. 
Published: October 2016

PurposeWe propose a new gradient measurement technique based on dynamic single‐point imaging (SPI), which allows simple, rapid, and robust measurement of k‐space trajectory.MethodsTo enable gradient measurement, we utilize the variable field‐of‐view (FOV) property of dynamic SPI, which is dependent on gradient shape. First, one‐dimensional (1D) dynamic SPI data are acquired from a targeted gradient axis, and then relative FOV scaling factors between 1D images or k‐spaces at varying encoding times are found. These relative scaling factors are the relative k‐space position that can be used for image reconstruction. The gradient measurement technique also can be used to estimate the gradient impulse response function for reproducible gradient estimation as a linear time invariant system.ResultsThe proposed measurement technique was used to improve reconstructed image quality in 3D ultrashort echo, 2D spiral, and multi‐echo bipolar gradient‐echo imaging. In multi‐echo bipolar gradient‐echo imaging, measurement of the k‐space trajectory allowed the use of a ramp‐sampled trajectory for improved acquisition speed (approximately 30%) and more accurate quantitative fat and water separation in a phantom.ConclusionThe proposed dynamic SPI‐based method allows fast k‐space trajectory measurement with a simple implementation and no additional hardware for improved image quality. Magn Reson Med 78:950–962, 2017. © 2016 International Society for Magnetic Resonance in Medicine
Chronic Pelvic Pain Development and Prostate Inflammation in Strains of Mice With Different Susceptibility to Experimental Autoimmune Prostatitis
Authors: Breser Maria L. , Motrich Ruben D. , Sanchez Leonardo R. , Rivero Virginia E. 
Published: October 2016

BACKGROUNDExperimental autoimmune prostatitis (EAP) is an autoimmune inflammatory disease of the prostate characterized by peripheral prostate‐specific autoimmune responses associated with prostate inflammation. EAP is induced in rodents upon immunization with prostate antigens (PAg) plus adjuvants and shares important clinical and immunological features with the human disease chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).METHODSEAP was induced in young NOD, C57BL/6, and BALB/c male mice by immunization with PAg plus complete Freund́s adjuvant. Tactile allodynia was assessed using Von Frey fibers as a measure of pelvic pain at baseline and at different time points after immunization. Using conventional histology, immunohistochemistry, FACS analysis, and protein arrays, an interstrain comparative study of prostate cell infiltration and inflammation was performed.RESULTSChronic pelvic pain development was similar between immunized NOD and C57BL/6 mice, although the severity of leukocyte infiltration was greater in the first case. Coversely, minimal prostate cell infiltration was observed in immunized BALB/c mice, who showed no pelvic pain development. Increased numbers of mast cells, mostly degranulated, were detected in prostate samples from NOD and C57BL/6 mice, while lower total counts and resting were observed in BALB/c mice. Prostate tissue from NOD mice revealed markedly increased expression levels of inflammatory cytokines, chemokines, adhesion molecules, vascular endothelial growth factor, and metalloproteinases. Similar results, but to a lesser extent, were observed when analyzing prostate tissue from C57BL/6 mice. On the contrary, the expression of the above mediators was very low in prostate tissue from immunized BALB/c mice, showing significantly slight increments only for CXCL1 and IL4.CONCLUSIONSOur results provide new evidence indicating that NOD, C57BL/6, and BALB/c mice develop different degrees of chronic pelvic pain, type, and amount of prostate cell infiltration and secretion of inflammatory mediators. Our results corroborate and support the notion that mice with different genetic background have different susceptibility to EAP induction. Prostate 77:94–104, 2017. © 2016 Wiley Periodicals, Inc.