bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chd7 Collaborates with Sox2 to Regulate Activation of Oligodendrocyte Precursor Cells after Spinal Cord Injury
Authors: Doi Toru , Ogata Toru , Yamauchi Junji , Sawada Yasuhiro , Tanaka Sakae , Nagao Motoshi 
Published: September 2017

Oligodendrocyte precursor cells (OPCs) act as a reservoir of new oligodendrocytes (OLs) in homeostatic and pathological conditions. OPCs are activated in response to injury to generate myelinating OLs, but the underlying mechanisms remain poorly understood. Here, we show that chromodomain helicase DNA binding protein 7 (Chd7) regulates OPC activation after spinal cord injury (SCI). Chd7 is expressed in OPCs in the adult spinal cord and its expression is upregulated with a concomitant increase in Sox2 expression after SCI. OPC-specific ablation of Chd7 in injured mice leads to reduced OPC proliferation, the loss of OPC identity, and impaired OPC differentiation. Ablation of Chd7 or Sox2 in cultured OPCs shows similar phenotypes to those observed inChd7knock-out mice. Chd7 and Sox2 form a complex in OPCs and bind to the promoters or enhancers of theregulator of cell cycle(Rgcc) andprotein kinase Cθ (PKCθ) genes, thereby inducing their expression. The expression of Rgcc and PKCθ is reduced in the OPCs of the injuredChd7knock-out mice. In cultured OPCs, overexpression and knock-down of Rgcc or PKCθ promote and suppress OPC proliferation, respectively. Furthermore, overexpression of both Rgcc and PKCθ rescues the Chd7 deletion phenotypes. Chd7 is thus a key regulator of OPC activation, in which it cooperates with Sox2 and acts via direct induction of Rgcc and PKCθ expression.SIGNIFICANCE STATEMENTSpinal cord injury (SCI) leads to oligodendrocyte (OL) loss and demyelination, along with neuronal death, resulting in impairment of motor or sensory functions. Oligodendrocyte precursor cells (OPCs) activated in response to injury are potential sources of OL replacement and are thought to contribute to remyelination and functional recovery after SCI. However, the molecular mechanisms underlying OPC activation, especially its epigenetic regulation, remain largely unclear. We demonstrate here that the chromatin remodeler chromodomain helicase DNA binding protein 7 (Chd7) regulates the proliferation and identity of OPCs after SCI. We have further identified regulator of cell cycle (Rgcc) and protein kinase Cθ (PKCθ) as novel targets of Chd7 for OPC activation.
Individual Alpha Peak Frequency Predicts 10 Hz Flicker Effects on Selective Attention
Authors: Gulbinaite Rasa , van Viegen Tara , Wieling Martijn , Cohen Michael X , VanRullen Rufin 
Published: September 2017

Rhythmic visual stimulation (“flicker”) is primarily used to “tag” processing of low-level visual and high-level cognitive phenomena. However, preliminary evidence suggests that flicker may also entrain endogenous brain oscillations, thereby modulating cognitive processes supported by those brain rhythms. Here we tested the interaction between 10 Hz flicker and endogenous alpha-band (∼10 Hz) oscillations during a selective visuospatial attention task. We recorded EEG from human participants (both genders) while they performed a modified Eriksen flanker task in which distractors and targets flickered within (10 Hz) or outside (7.5 or 15 Hz) the alpha band. By using a combination of EEG source separation, time-frequency, and single-trial linear mixed-effects modeling, we demonstrate that 10 Hz flicker interfered with stimulus processing more on incongruent than congruent trials (high vs low selective attention demands). Crucially, the effect of 10 Hz flicker on task performance was predicted by the distance between 10 Hz and individual alpha peak frequency (estimated during the task). Finally, the flicker effect on task performance was more strongly predicted by EEG flicker responses during stimulus processing than during preparation for the upcoming stimulus, suggesting that 10 Hz flicker interfered more with reactive than proactive selective attention. These findings are consistent with our hypothesis that visual flicker entrained endogenous alpha-band networks, which in turn impaired task performance. Our findings also provide novel evidence for frequency-dependent exogenous modulation of cognition that is determined by the correspondence between the exogenous flicker frequency and the endogenous brain rhythms.SIGNIFICANCE STATEMENTHere we provide novel evidence that the interaction between exogenous rhythmic visual stimulation and endogenous brain rhythms can have frequency-specific behavioral effects. We show that alpha-band (10 Hz) flicker impairs stimulus processing in a selective attention task when the stimulus flicker rate matches individual alpha peak frequency. The effect of sensory flicker on task performance was stronger when selective attention demands were high, and was stronger during stimulus processing and response selection compared with the prestimulus anticipatory period. These findings provide novel evidence that frequency-specific sensory flicker affects online attentional processing, and also demonstrate that the correspondence between exogenous and endogenous rhythms is an overlooked prerequisite when testing for frequency-specific cognitive effects of flicker.
Variation in Position Effect Variegation Within a Natural Population
Authors: Kelsey Keegan J P , Clark Andrew G 
Published: September 2017

AbstractChanges in chromatin state may drive changes in gene expression, and it is of growing interest to understand the population genetic forces that drive differences in chromatin state. Here, we use the phenomenon of position effect variegation (PEV), a well-studied proxy for chromatin state, to survey variation in PEV among a naturally derived population. Further, we explore the genetic architecture of natural variation in factors that modify PEV. While previous mutation screens have identified over 150 suppressors and enhancers of PEV, it remains unknown to what extent allelic variation in these modifiers mediate interindividual variation in PEV. Is natural variation in PEV mediated by segregating genetic variation in known Su(var) and E(var) genes, or is the trait polygenic, with many variants mapping elsewhere in the genome? We designed a dominant mapping study that directly answers this question and suggests that the bulk of the variance in PEV does not map to genes with prior annotated impact to PEV. Instead, we find enrichment of top P-value ranked associations that suggest impact to active promoter and transcription start site proximal regions. This work highlights extensive variation in PEV within a population, and provides a quantitative view of the role naturally segregating autosomal variants play in modifying PEV—a phenomenon that continues to shape our understanding of chromatin state and epigenetics.
Isothermal and thermo-mechanical fatigue behavior of 16Mo3 steel coated with high-velocity oxy-fuel sprayed nickel-base alloy under uniaxial as well as biaxial-planar loading
Authors: Kulawinski Dirk , Hoffmann Markus , Lippmann Tim , Lamprecht Götz , Weidner Anja , Henkel Sebastian , Biermann Horst 
Published: September 2017

Abstract
Chronisch-entzündliche Darmerkrankungen beim Hund – diagnostische und therapeutische Aspekte
Authors: Heilmann Romy , Erdmann Carolin 
Published: September 2017

ZusammenfassungAls chronische Enteropathien werden über mindestens 3 Wochen andauernde gastrointestinale Symptome wie Vomitus, Diarrhö, Borborygmus, Gewichtsverlust oder abdominale Dolenz bezeichnet. Die Diagnose erfordert Labor- und Kotuntersuchungen sowie bildgebende Diagnostik zum Ausschluss infektiöser oder mechanisch-obstruktiver gastrointestinaler sowie extragastrointestinaler Ursachen. Spezifische labordiagnostische Tests wie z. B. die Bestimmung der Cobalamin- und Folsäurekonzentration im Serum geben zudem Hinweise auf das Vorliegen einer distalen bzw. proximalen Dünndarmerkrankung. Die chronische Enteropathie beinhaltet die Futtermittel-responsive (FRE), Antibiotika-responsive (ARE), Immunsuppressiva-responsive bzw. -refraktäre (IRE) und nichtresponsive Enteropathie (NRE), die retrospektiv durch ihr Ansprechen auf empirische Therapieversuche diagnostiziert werden. Eine Sonderstellung nimmt die Proteinverlust-Enteropathie (PLE) ein, die mit einer schlechteren Prognose einhergeht. Sie stellt eine Folge verschiedener Grunderkrankungen dar, wie schwergradige entzündliche oder neoplastische Darmerkrankungen oder primäre intes tinale Lymphangiektasien. Zur besseren Vergleichbarkeit des Schweregrades der Erkrankung und zur objektiveren Einschätzung einer Verbesserung der klinischen Symptomatik unter Therapie dienen numerische Bewertungssysteme (CIBDAI, CCECAI), die die Ausprägung verschiedener klinischer sowie labordiagnostischer Parameter bewerten. Die Prognose der chronischen Enteropathie ist abhängig von der zugrundeliegenden Ursache. Tiere mit FRE zeigen meist ein schnelles Ansprechen und eine gute Langzeitkontrolle ihrer Erkrankung. Bei Hunden mit IRE oder PLE besteht hingegen ein variabler Therapieerfolg und es kommt häufig zu Rückfällen.
Cambios en el autocuidado de estudiantes de enfermería colombianos, durante la formación profesional. 2015
Authors: Escobar Potes María del Pilar , Mejía Uribe Ángela María , Betancur López Sonia Inés 
Published: September 2017

Objetivo: Describir cambios en las prácticas de autocuidado de estudiantes de enfermería de universidades colombianas, durante la formación profesional. Materiales y métodos: Se realizó un estudio descriptivo correlacional, de corte trasversal, con enfoque cuantitativo; n = 487 a estudiantes de enfermería de ocho universidades colombianas. Se diseñó una encuesta para recolectar información sobre variables sociodemográficas, prácticas protectoras y de riesgo para la salud, adquiridas antes o durante la carrera, o modificados durante la formación profesional, que se aplicó por medio de la herramienta Google Drive, previo consentimiento informado. Resultados: Al ingresar a la universidad, las prácticas protectoras presentes fueron: higiene y cuidado personal en 84,8%, cuidado de la piel en 50% y asistencia a programas de promoción de la salud y prevención de la enfermedad, 39,2%; las prácticas preventivas en el ejercicio de la sexualidad y las habilidades sociales para vivir, presentaron cambios positivos en el 32,4% y el 47,84%, respectivamente. Fueron interrumpidas frecuentemente y abandonadas: actividad física por 76,2% y recreación y tiempo de ocio por 65,2%.; los patrones de alimentación presentaron cambios negativos en 22,8%. Entre quienes consumen bebidas energizantes, el 13% lo aumentó y 50,9% se automedican. Conclusiones: El proceso de formación incide positivamente en la asistencia a programas de promoción de la salud y prevención de la enfermedad, cuidado de la piel, habilidades para vivir y ejercicio de la sexualidad y negativamente en actividad física, recreación y tiempo de ocio, patrones de alimentación, consumo de bebidas energizantes y automedicación.
Predictores psicológicos del autocuidado en salud
Authors: Gómez Acosta Andrés 
Published: September 2017

Objetivo: Determinar en qué medida los estilos de afrontamiento, la autoeficacia percibida, la salud mental positiva y las creencias saludables, en interacción, predicen la ocurrencia de pautas de autocuidado en salud con una muestra de 570 adultos jóvenes. Materiales y Métodos: Se aplicó una batería compuesta por instrumentos validados para evaluar la presencia de las variables criterio. Con la información obtenida se desarrollaron análisis descriptivos, de diferencias de medias y correlacionales, así como un análisis multivariado con un modelo de ecuaciones estructurales (MEE). Resultados: Se identifican altos puntajes en los factores psicológicos protectores, en las creencias y en las prácticas saludables; así mismo, se reportan diferencias significativas en el autocuidado de acuerdo con el sexo y el estrato socioeconómico, y correlaciones importantes entre los factores psicológicos adaptativos con el autocuidado en salud. Por último, el MEE que mostró mayor ajuste, explica un 39% de la varianza asociada con las prácticas de autocuidado en salud. Conclusión: El modelo, aunque no es concluyente, puede brindar soporte conceptual y empírico para crear estrategias en promoción del autocuidado en salud con población de adulto joven.
Kulttuuripolitiikka ja nationalismi kilpailuvaltio-Suomessa: innovatiivinen luova talous
Authors: Jakonen Olli 
Published: September 2017

Nationalism is constitutive of modern political forms of social life and also historically one of the key features defining cultural policy in modern nation states. Regardless of transformations called globalization, methodological nationalism remains rooted also in the underlying logic of national cultural policies. In the 1990s the Finnish welfare-state shifted towards so-called competition state. In Finnish public cultural policy this marked a shift from a welfare orientation towards a more economy-oriented neo-liberal rationale. Alongside the old welfare and cultural nationalisms, new forms of nationalism emphasizing individual creativity, innovation and economic value of art and culture emerged in cultural policy discourses in a framework of national competitiveness. This article looks into economic rationale and competitiveness as one of the thriving paradigms of cultural policy and nationalism in the field of culture from the 1990’s onwards. It examines discursively the idea of innovative knowledge and creative economy as an example of national-economic project which has somewhat blurred the definitions of culture and creativity. Furthermore, the article discusses the idea of creative economy in the institutional politics of different administrational sectors.
Keywords: Competition state, nationalism, neoliberalism, creative economy, cultural policy strategies.
PERSONNEL PROCESSES IN MEDICAL ORGANIZATIONS: THE STATE AND DIRECTIONS OF REGULATION
Authors: Kaprina I. A. 
Published: September 2017

Results of sociological research of problem questions of regulation of personnel processes in the medical organizations are presented in this article. The problem of reforming medical organizations is characterized. Proposals on the solution of currently important problems of personnel regulation in medical organizations are formulated.The purpose of the research is to substantiate the directions of improving the management of personnel processes in modern medical organizations based on the sociological analysis of personnel processes and relations in medical organizations.Materials and methods. The paper presents the results of a sociological study of the condition and problems of regulation of personnel processes in medical organizations. The survey involved 240 respondents from among the employees of medical organizations and 97 qualified medical experts.Results. It is proved that the successful functioning of medical organizations is possible with a scientific approach to the management of personnel processes and relations, including analysis of personnel policy issues, sociological support of personnel processes regulation, development of human resources technologies in modern medical organizations.Conclusions. Successful functioning of medical organizations is possible with a scientific approach to the management of personnel processes and relations, including analysis of personnel policy issues, sociological support of personnel processes regulation, development of modern personnel technologies in medical organizations. Achievement of effective management of personnel processes in medical organizations requires the development and implementation of scientifically sound human resources policy in the health care system, improving the regulatory and organizational support for the regulation of personnel processes, enhancing the role of self-regulatory organizationsin the management of personnel processes in medical organizations.
REVIEW OF APPROACHES TO IMMUNOTHERAPY IN ONCOLOGY
Authors: Tsarev I. L. , Melerzanov A. V. 
Published: September 2017

The article discusses modern ideas about the immune therapy of cancer — methods of treatment of oncological diseases based on immunological reactions of the organism to the appearance of malignant cells in it. This area is actively studied in clinical practice in the last decade, and some therapy has already been approved for use by regulators after promising results of clinical trials 3 phase.Immune therapy is based on antitumor immune cycle — the cascade of processes responsible for the immune system’s response to tumor cells. Involved regulatory mechanisms are targets for various therapies, the overall goal is to restore proper functioning of the cycle and to achieve the elimination of cancer cells.Currently, the most studied two types of immune therapy — checkpoint inhibitors and adaptive cell therapy. Checkpoint inhibitors increase the activity of body immune cells, reducing the inhibitory influence of the tumor microenvironment and the tumor cells themselves, which allowed them to get out from under the pressure of the immune system during the development of the disease. Adaptive cell therapy, in turn, allows to compensate the lack of active immune against tumor cells.Mechanisms of action determine the effectiveness of various therapies for different diseases, and for patients inside of one diagnosis. To determine the effectiveness of other treatment prior to a particular patient it is necessary to use the latest achievements in precision medicine, based on the search for new biomarkers and analyzing each patient separately. This approach will significantly reduce costs and save precious time for the patient.
An Uniformly Minimum Variance Unbiased Point Estimator Using Fuzzy Observations
Authors: Akbari Mohammad Ghasem , Rezaei Abdolhamid 
Published: September 2017

This paper proposes a new method for uniformly minimum variance unbiased fuzzy point estimation. For this purpose we make use of a uniformly minimum variance unbiased estimator and we develop this new method for a fuzzy random sample ~X1,...,~Xn is induced by X1,,...,Xn onthe same probability space.
Effectiveness of Alkali and Acid to Produce Collagen from Fish Skin of Striped Catifish
Authors: Devi Hilda Lu’lu’in Nanda Alfira , Suptijah Pipih , Nurilmala Mala 
Published: September 2017

Fish skin is one of the alternative sources contained high protein to isolate collagen. Fish skin generally extracted by the method of acid, alkali and enzymes. The study aim to determine the effectiveness of NaOH<br />and acetic acid on catfish (Pangasius sp.) skin extraction process. The concentrations of alkaline pretreatment were 0,05; 0,1; 0,15 and 0,2 M with the soaking time of 2, 4, 6, 8 and 10 h by NaOH replacement in every 2 h. The concentrations of acetic acid for hydrolisis process were 0.05; 0.1; 0.15 and 0.2 M with the soaking time of 1, 2, and 3 h. The experimental design used for pretreatment process is split splot, while for the hydrolysis process is factorial completely randomized design. The results showed that pretreatment with a concentration of 0.05 M NaOH for 4 h has a significant effect for eliminating non-collagen protein (p&lt;0.05). The acetic acid concentration of 0.15 M for 1 h also has a significant effect on fish skin swelling. The yield of striped catfish collagen was 17.272%, the protein content was 86%, and the viscosity was 12 cP. Fish skin extract was identified as type I collagen by functional groups and electrophoretic analysis. Collagen from striped catfish skin has α1 and α2 and protein structure with the molecular weight of α chain were 94 and 98 kDa, meanwhile the molecular wheight of β chain was 204 kD.
KEPEMIMPINAN PERGURUAN DALAM PERSPEKTIF TEORI INTERAKSIONISME SIMBOLIK DAN DRAMATURGI
Authors: Wahyudin Wahyudin 
Published: September 2017

Penelitian ini membahas tentang kepemimpinan perguruan tinggi dalam perspektif teori interaksionisme. Dramaturgi memahami bahwa dalam interaksi antara manusia ada kesepakatan perilaku yang disetujui yang dapat mengantarkan kepada tujuan akhir dari maksud interaksi sosial tersebut. Bermain peran merupakan salah satu alat yang dapat mengacu kepada tercapainya kesepakatan tersebut. bukti nyata bahwa terjadi permainan peran dalam kehidupan manusia dapat dilihat pada masyarakat kita sendiri. Manusia menciptakan sebuah mekanisme tersendiri, dimana dengan permainan peran tersebut ia bisa tampil sebagai sosok- sosok tertentu.Sebagaimana pemikiran Blumer, pemikiran Goffmanmelihat masyarakat terdiri atas kehidupan yang diliputi oleh berbagai tingkah laku. Goffman selalu memandang bahwa perilaku keseharian dan interaksi tatap muka diibaratkan sama dengan panggung teater/drama.
POTENCIAL ARQUEOLÓGICO DA ILHA DOS MARINHEIROS DE RIO GRANDE
Authors: Da Silveira Cleiton Silva 
Published: September 2017

O presente trabalho apresenta uma proposta de um hipermapa da Ilha dos Marinheiros no contexto da arqueologia pré-colonial. O objetivo foi reunir as informações arqueológicas da ilha com as já existentes sobre a geomorfologia, geologia, características biológicas, sociais, etc. Também realizou-se um levantamento fotográfico completo do material da Ilha contido no acervo do Laboratório de Arqueologia e Antropologia da Universidade Federal do Rio Grande (LEPAN- FURG), trazendo a tona informações dos sítios anteriormente estudados. Os métodos apresentados aqui consistem na criação de um ambiente de hipermapa através da manipulação de arquivos KML usando o Google Earth, sendo disponibilizado num web site desenvolvido na plataforma Joomla ou com a ferramenta Blogger.
Turismo arqueológico, educação e os sambaquis do complexo lagunar sul de Santa Catarina: proposta de um circuito para visitação
Authors: Guimarães Geovan Martins , Zamparetti Bruna Cataneo , Farias Deisi Scunderlick Eloy de , Anjos Francisco Antônio dos 
Published: September 2017

Os sambaquis são sítios arqueológicos construídos por grupos pescadores-caçadores-coletores pré-coloniais, sendo recorrentes no litoral sul do Estado de Santa Catarina. Apresentam características funerárias e ritualísticas, tendo como principal elemento construtivo os moluscos, que acumulados ao longo dos anos, formaram grandes montes que ultrapassaram 40 metros de altura. Esse importante patrimônio arqueológico vem sendo depredado ao longo do tempo. Inicialmente eram desmontados para a construção das primeiras vilas, no período colonial, após as indústrias caieiras, e posteriormente como elemento de aterro de estradas e lotes nos municípios. Atualmente a expansão urbana e a prática de esportes radicais são os problemas que afetam os sítio arqueológico. Apesar da vulnerabilidade dos sambaquis, essa realidade pode ser transformada, desde que medidas legais estejam aliadas às ações de valorização para a sensibilização e preservação do patrimônio arqueológico regional. Desta forma, objetiva-se neste artigo propor ações de visibilidade e valorização do patrimônio arqueológico regional, sobretudo, os Sambaquis.
As camadas na floresta do simbólico: uma leitura do livro “Diferença e descobrimento: o que é o imaginário? A hipótese do excedente de significação”, de Juremir Machado da Silva (2017)
Authors: Machado Anderson Dos Santos 
Published: September 2017

Resenha do livro “Diferença e descobrimento: o que é o imaginário? A hipótese do excedente de significação”, de Juremir Machado da Silva (2017)