bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban branding and place as a quality product: innovations in the urban experience
Authors: Sepe Marichela , Pitt Michael 
Published: February 2017

Purpose
Starting from these premises, the aim of the paper is illustrating the role of experience in urban regeneration projects and to explore how the experience of high quality product luxury places can be sustainable with existent place identity or new place identity to be suitably created.

Design/methodology/approach
The experience of a place may become an integral part of a product experience. The enhancement of products (Splendiani, 2013): assumes a meaning which goes beyond the simple sale of material goods. It covers the supply of complex experiences … enriched by intangible elements capable to stimulate and involve the sensory and experiential component of consumption. It deals with attracting people to the places where local products are made by inserting the products in the most extensive offers covering the entire territorial system of reference The experience may also be used for the spectacolarisation of a place and its commercialisation, as in the case of “brandscapes” (Klingman, 2007). In this case, it is important not to clone every place everywhere because they could inevitably resemble each other without be able to really engage the people who move into them (Lehtovuori, 2010). The methodology approach is based on a wide bibliography and internet research based on the main terms connected to the topics of the paper, including experience, place identity, quality product, regeneration; on case studies – even though not illustrated – concerning places of interest for the research topics, such as: Hafencity in Hamburg, the Albert Dock in Liverpool, Abondaibarra area in Bilbao.

Findings
The planning of places of quality product cannot be separated from interpretation of the territory as a cultural system resulting from an ensemble of historical, economic and social processes. In such a system, the contribution of the cultural factor must be considered propulsive, not only for its qualitative meaning but also, and especially, for the role of “trait d’union” of a number of actions taken to protect and enhance places.

Originality/value
The increasing importance of the use of experience in the urban regeneration process is leading cities to be involved in constructing suitable images and symbols of their transformed areas to meet the new trends, also according with luxurious ones. Even though globalisation is one of the main dangers in innovative itineraries, the proper planning of quality architecture and public spaces could prevent it by creating a suitable mix between innovation and culture.
Parsimonious wave‐equation travel‐time inversion for refraction waves
Authors: Fu Lei , Hanafy Sherif M. , Schuster Gerard T. 
Published: February 2017

ABSTRACTWe present a parsimonious wave‐equation travel‐time inversion technique for refraction waves. A dense virtual refraction dataset can be generated from just two reciprocal shot gathers for the sources at the endpoints of the survey line, with N geophones evenly deployed along the line. These two reciprocal shots contain approximately 2N refraction travel times, which can be spawned into refraction travel times by an interferometric transformation. Then, these virtual refraction travel times are used with a source wavelet to create N virtual refraction shot gathers, which are the input data for wave‐equation travel‐time inversion. Numerical results show that the parsimonious wave‐equation travel‐time tomogram has about the same accuracy as the tomogram computed by standard wave‐equation travel‐time inversion. The most significant benefit is that a reciprocal survey is far less time consuming than the standard refraction survey where a source is excited at each geophone location.
Japanese Bank Productivity, 2007–2012: A Dynamic Network Approach
Authors: Fukuyama Hirofumi , Weber William L. 
Published: February 2017

AbstractWe estimate a dynamic network (DN) directional output distance function for 100 Japanese banks operating during 2007–2012. Network production occurs in that deposits and other funds raised are produced as intermediate products in stage 1 and those intermediate products are used to generate a portfolio of assets in stage 2. The dynamic technology links production periods via nonperforming loans (NPL) and carryover assets, which take the form of excess reserves. Carryover assets expand the future production possibility set while NPL shrink future production possibilities. We extend previous DN methods to measure the performance of three types of Japanese commercial banks: city banks, regional banks and second regional banks. We test for and find differences in the three bank technologies relative to a common technology. Such differences are likely due to different institutional and regulatory structures. Unlike previous DN studies, we also allow for a non‐uniform abatement factor between previously‐produced NPL and other inputs in stage 1 and between performing loans and NPL in the current period. Measured productivity change is greater when each bank faces their own group technology rather than the pooled technology consisting of all bank types.
Optimisation of the formulation for barley–milk composite‐based fermented drink
Authors: Ahuja Kunal Kumar , Singh Ashish Kumar , Bala Kiran , Arora Sumit , Sabikhi Latha 
Published: February 2017

The effect of barley flour concentration, Lactobacillus plantarum NCDC344 (Lp344) and co‐culture (Streptococcus thermophilus 20) inoculum levels on the sensory quality, Lp344 count, β‐glucan content and viscosity of barley–milk composite‐based fermented drink was investigated. A central composite rotatable design of response surface methodology was used for optimisation of the formulation. Of the three formulation variables, barley flour concentration was found to be the most critical as it significantly affected overall acceptability, Lp344 count and β‐glucan content (P < 0.01). The optimised drink rated 7.80 on a 9‐point hedonic scale, and contained 8.59 log cfu/mL of Lp344 cells and 0.144 g/100 g of β‐glucan.
Vitamin K Antagonist Therapy Is a Risk Factor for Ulcer Development and Death Among Dialyzed Patients
Authors: De Mauri Andreana , Torreggiani Massimo , Brambilla Marco , Chiarinotti Doriana 
Published: February 2017

AbstractPeripheral artery disease is a common complication among dialyzed patients. Since Vitamin K antagonists promote metastatic calcifications and these are the main determinants of vascular damage, we investigated their role in the development of lower limb ulcers in dialyzed patients. We retrospectively enrolled 316 dialyzed patients, aged 68 ± 15 years, 65% male, 32% diabetic, 43% with ischemic heart disease and followed them for 36 ± 25 months. 60 patients assumed Vitamin K antagonists: they were older, with a higher prevalence of heart disease, at greater risk of death and they developed more ulcers and underwent more lower limb amputations compared to the rest of our cohort. Peripheral artery disease, Vitamin K antagonists and diabetes were independent risk factors for foot lesions. In addition, Vitamin K antagonists were also an independent risk factor for death. Vitamin K antagonists are a potent independent risk factor for the development of the uremic foot syndrome and death.
Self‐Care on Hemodialysis: Behaviors With the Arteriovenous Fistula
Authors: Sousa Clemente Neves , Marujo Patrícia , Teles Paulo , Lira Marta Nunes , Novais Maria Eulália Leite Mota 
Published: February 2017

AbstractEnd stage renal disease (ESRD) patients should be educated to maintain and preserve the arteriovenous fistula (AVF) in the best condition. The purpose of this work was to evaluate self‐care frequency and factors that influenced such frequency. A prospective study was performed in 101 hemodialysis patients. Self‐care behaviors were measured with the Scale of Assessment of Self‐Care Behaviours with Arteriovenous Fistula in Hemodialysis. A regression model was used to determine the relevant predictors of self‐care frequency and their influence. The incidence of self‐care behaviors was 71.0%. The regression model showed that self‐care behaviors were positively influenced by gender (female), ESRD etiology (hypertension, polycystic kidneys and other kidney diseases), duration of AVF and negatively by the existence of previous AVF and health professional (doctor). The frequency of self‐care behaviors was lower than expected and below an appropriate standard. Education programs designed to improve self‐care behaviors with AVF should be further explored in a prospective randomized trial.
Alcohol Injury Damages Intestinal Stem Cells
Authors: Lu Rong , Voigt Robin M. , Zhang Yongguo , Kato Ikuko , Xia Yinglin , Forsyth Christopher B. , Keshavarzian Ali , Sun Jun 
Published: February 2017

BackgroundAlcohol consumption is associated with intestinal injury including intestinal leakiness and the risk of developing progressive gastrointestinal cancer. Alcoholics have disruption of intestinal barrier dysfunction that persists weeks after stopping alcohol intake, and this occurs in spite of the fact that intestinal epithelial cells turn over every 3 to 5 days. The renewal and functional regulation of the intestinal epithelium largely relies on intestinal stem cells (ISCs). Chronic inflammation and tissue damage in the intestine can injure stem cells including accumulation of mutations that may result in ISC dysfunction and transformation. ISCs are a key element in intestinal function and pathology; however, very little is known about the effects of alcohol on ISCs. We hypothesize that dysregulation of ISCs is one mechanism by which alcohol induces long‐lasting intestinal damage.MethodsIn Vivo: Small intestinal samples from alcohol‐ and control‐fed mice were assessed for ISC markers (Lgr5 and Bmi1) and the changes of the β‐catenin signaling using immunofluorescent microscopy, Western blotting, and RT‐PCR. Ex Vivo: Organoids were generated from small intestine tissue and subsequently exposed to alcohol and analyzed for ISC markers, β‐catenin signaling.ResultsChronic alcohol consumption significantly decreased the expression of stem cell markers, Bmi1 in the small intestine of the alcohol‐fed mice and also resulted in dysregulation of the β‐catenin signaling—an essential regulator of its target gene Lgr5 and ISC function. Exposure of small intestine‐derived organoids to 0.2% alcohol significantly reduced the growth of the organoids, including budding, and total surface area of the organoid cultures. Alcohol also significantly decreased the expression of Lgr5, p‐β‐catenin (ser552), and Bmi1 in the organoid model.ConclusionsBoth chronic alcohol feeding and acute exposure of alcohol resulted in ISC dysregulation which might be one mechanism for alcohol‐induced long‐lasting intestinal damage.
Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence
Authors: Clark Shaunna L. , McClay Joseph L. , Adkins Daniel E. , Kumar Gaurav , Aberg Karolina A. , Nerella Srilaxmi , Xie Linying , Collins Ann L. , Crowley James J. , Quackenbush Corey R. , Hilliard Christopher E. , Shabalin Andrey A. , Vrieze Scott I. , Peterson Roseann E. , Copeland William E. , Silberg Judy L. , McGue Matt , Maes Hermine , Iacono William G. , Sullivan Patrick F. , Costello Elizabeth J. , van den Oord Edwin J. 
Published: February 2017

BackgroundPrevious genomewide association studies (GWASs) have identified a number of putative risk loci for alcohol dependence (AD). However, only a few loci have replicated and these replicated variants only explain a small proportion of AD risk. Using an innovative approach, the goal of this study was to generate hypotheses about potentially causal variants for AD that can be explored further through functional studies.MethodsWe employed targeted capture of 71 candidate loci and flanking regions followed by next‐generation deep sequencing (mean coverage 78X) in 806 European Americans. Regions included in our targeted capture library were genes identified through published GWAS of alcohol, all human alcohol and aldehyde dehydrogenases, reward system genes including dopaminergic and opioid receptors, prioritized candidate genes based on previous associations, and genes involved in the absorption, distribution, metabolism, and excretion of drugs. We performed single‐locus tests to determine if any single variant was associated with AD symptom count. Sets of variants that overlapped with biologically meaningful annotations were tested for association in aggregate.ResultsNo single, common variant was significantly associated with AD in our study. We did, however, find evidence for association with several variant sets. Two variant sets were significant at the q‐value <0.10 level: a genic enhancer for ADHFE1 (p = 1.47 × 10−5; q = 0.019), an alcohol dehydrogenase, and ADORA1 (p = 5.29 × 10−5; q = 0.035), an adenosine receptor that belongs to a G‐protein‐coupled receptor gene family.ConclusionsTo our knowledge, this is the first sequencing study of AD to examine variants in entire genes, including flanking and regulatory regions. We found that in addition to protein coding variant sets, regulatory variant sets may play a role in AD. From these findings, we have generated initial functional hypotheses about how these sets may influence AD.
The prevalence of dental anomalies in an Australian population
Authors: Dang HQ , Constantine S , Anderson PJ 
Published: February 2017

AbstractBackgroundThe aim of this study was to determine the prevalence of dental anomalies within an Australian paediatric population using panoramic radiographs.MethodsThis was a prospective review of 1050 panoramic radiographs obtained as part of a school dental screening program in suburban and rural New South Wales, Australia.ResultsFifty‐four (5.14%) patients had a dental anomaly present. Agenesis was noted to have occurred 69 times across 45 patients (4.28%), along with seven cases of impaction (0.6%) and three cases of supernumerary teeth (0.28%).ConclusionsDental anomalies rarely occur in the Australian population, which possesses a wide‐ranging multiethnic cohort. Despite their rarity, they can be incidentally discovered so identification and management by dental practitioners are important.
Early‐onset neonatal sepsis is associated with a high heart rate during automatically selected stationary periods
Authors: Nguyen Nga , Vandenbroucke Laurent , Hernández Alfredo , Pham Tu , Beuchée Alain , Pladys Patrick 
Published: February 2017

AbstractAimThis study examined the heart rate variability characteristics associated with early‐onset neonatal sepsis in a prospective, observational controlled study.MethodsEligible patients were full‐term neonates hospitalised with clinical signs that suggested early‐onset sepsis and a C‐reactive protein of >10 mg/L. Sepsis was considered proven in cases of symptomatic septicaemia, meningitis, pneumonia or enterocolitis. Heart rate variability parameters (n = 16) were assessed from five‐, 15‐ and 30‐minute stationary sequences automatically selected from electrocardiographic recordings performed at admission and compared with a control group using the U‐test with post hoc Benjamini‐Yekutieli correction. Stationary sequences corresponded to the periods with the lowest changes of heart rate variability over time.ResultsA total of 40 full‐term infants were enrolled, including 14 with proven sepsis. The mean duration of the cardiac cycle length was lower in the proven sepsis group than in the control group (n = 11), without other significant changes in heart rate variability parameters. These durations, measured in five‐minute stationary periods, were 406 (367–433) ms in proven sepsis group versus 507 (463–522) ms in the control group (p < 0.05).ConclusionEarly‐onset neonatal sepsis was associated with a high mean heart rate measured during automatically selected stationary periods.
Mutational spectrum of the SERPING1 gene in Swiss patients with hereditary angioedema
Authors: Steiner U C , Keller M , Schmid P , Cichon S , Wuillemin W A 
Published: February 2017

Summary
Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare autosomal dominant disease caused by mutations in the C1 inhibitor gene SERPING1. Phenotype and clinical features of the disease are extremely heterogeneous, varying even within the same family. Compared to HAE cohorts in other countries, the genetic background of the Swiss HAE patients has not yet been elucidated. In the present study we investigated the mutational spectrum of the SERPING1 gene in 19 patients of nine unrelated Swiss families. The families comprise a total of 111 HAE-affected subjects which corresponds to approximately 70% of all HAE-affected patients living in Switzerland. Three of the identified mutations are newly described. Members of family A with a nucleotide duplication as genetic background seem to have a more intense disease manifestation with a higher attack frequency compared to the other families. Newly designed genetic screening tests allow a fast and cost-efficient testing for HAE in other family members.
Chlorhexidine allergy in four specialist allergy centres in the United Kingdom, 2009–13: clinical features and diagnostic tests
Authors: Egner W , Helbert M , Sargur R , Swallow K , Harper N , Garcez T , Savic S , Savic L , Eren E 
Published: February 2017

Summary
We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics in the United Kingdom following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life-threatening. Men undergoing urological or cardiothoracic surgery predominated. Skin prick testing and specific immunoglobulin (sIg)E testing were the most common tests used for diagnosis. Fifty-three per cent of diagnoses were made on the basis of a single positive test. Where multiple tests were performed the sensitivity of intradermal, basophil activation and skin prick testing was 68% (50–86%), 50% (10–90%) and 35% (17–55%), respectively. Seven per cent were negative on screening tests initially, and 12 cases were only positive for a single test despite multiple testing. Intradermal tests appeared most sensitive in this context. Additional sensitization to other substances used perioperatively, particularly neuromuscular blocking agents (NMBA), was found in 28 patients, emphasizing the need to test for possible allergy to all drugs to which the patient was exposed even where chlorhexidine is positive.
Association of peripheral NK cell counts with Helios+IFN-γ– Tregs in patients with good long-term renal allograft function
Authors: Trojan K , Zhu L , Aly M , Weimer R , Bulut N , Morath C , Opelz G , Daniel V 
Published: February 2017

Summary
Little is known about a possible interaction of natural killer (NK) cells with regulatory T cells (Treg) in long-term stable kidney transplant recipients. Absolute counts of lymphocyte and Treg subsets were studied in whole blood samples of 136 long-term stable renal transplant recipients and 52 healthy controls using eight-colour fluorescence flow cytometry. Patients were 1946 ± 2201 days (153–10 268 days) post-transplant and showed a serum creatinine of 1·7 ± 0·7 mg/dl. Renal transplant recipients investigated &gt; 1·5 years post-transplant showed higher total NK cell counts than recipients studied &lt; 1·5 years after transplantation (P = 0·006). High NK cells were associated with high glomerular filtration rate (P = 0·002) and low serum creatinine (P = 0·005). Interestingly, high NK cells were associated with high CD4+CD25+CD127–forkhead box protein 3 (FoxP3+) Treg that co-express the phenotype Helios+interferon (IFN)-γ– and appear to have stable FoxP3 expression and originate from the thymus. Furthermore, high total NK cells were associated with Treg that co-express the phenotypes interleukin (IL)−10–transforming growth factor (TGF)-β+ (P = 0·013), CD183+CD62L– (P = 0·003), CD183+CD62+(P = 0·001), CD183–CD62L+ (P = 0·002), CD252–CD152+ (P &lt; 0·001), CD28+human leucocyte antigen D-related (HLA-DR–) (P = 0·002), CD28+HLA-DR+ (P &lt; 0·001), CD95+CD178– (P &lt; 0·001) and CD279–CD152+ (P &lt; 0·001), suggesting that these activated Treg home in peripheral tissues and suppress effector cells via TGF-β and cytotoxic T lymphocyte-associated protein 4 (CTLA-4). The higher numbers of NK and Treg cell counts in patients with long-term good allograft function and the statistical association of these two lymphocyte subsets with each other suggest a direct or indirect (via DC) interaction of these cell subpopulations that contributes to good long-term allograft acceptance. Moreover, we speculate that regulatory NK cells are formed late post-transplant that are able to inhibit graft-reactive effector cells.
Use of multigene‐panel identifies pathogenic variants in several CRC‐predisposing genes in patients previously tested for Lynch Syndrome
Authors: Hansen Maren F. , Johansen Jostein , Sylvander Anna E. , Bjørnevoll Inga , Talseth‐Palmer Bente A. , Lavik Liss A. S. , Xavier Alexandre , Engebretsen Lars F. , Scott Rodney J. , Drabløs Finn , Sjursen Wenche 
Published: February 2017

BackgroundMany families with a high burden of colorectal cancer fulfil the clinical criteria for Lynch Syndrome. However, in about half of these families, no germline mutation in the mismatch repair genes known to be associated with this disease can be identified. The aim of this study was to find the genetic cause for the increased colorectal cancer risk in these unsolved cases.Materials and methodsTo reach the aim, we designed a gene panel targeting 112 previously known or candidate colorectal cancer susceptibility genes to screen 274 patient samples for mutations. Mutations were validated by Sanger sequencing and, where possible, segregation analysis was performed.ResultsWe identified 73 interesting variants, of whom 17 were pathogenic and 19 were variants of unknown clinical significance in well‐established cancer susceptibility genes. In addition, 37 potentially pathogenic variants in candidate colorectal cancer susceptibility genes were detected.ConclusionIn conclusion, we found a promising DNA variant in more than 25 % of the patients, which shows that gene panel testing is a more effective method to identify germline variants in CRC patients compared to a single gene approach.