bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compliance of tranexamic acid administration to trauma patients at a level-one trauma centre
Authors: Ghawnni Abeer , Coates Angela , Owen Julian 
Published: July 2017

AbstractIntroductionCurrent practice for the treatment of traumatic hemorrhage includes fluid resuscitation and the administration of blood products. The administration of tranexamic acid (TXA) within 8 hours of injury has been shown to significantly reduce mortality in a large, prospective, randomized controlled trial. As a result, TXA is widely used in trauma centres to manage trauma patients with major bleeding. The primary aim of this study was to assess the compliance of TXA administration at a level-one trauma centre in Hamilton, Ontario, Canada.MethodsWe conducted a retrospective medical record review of consecutive adult trauma patients received at the Hamilton General Hospital between January 1, 2012 and December 31, 2014. Compliance with TXA administration was based on the inclusion criteria of the CRASH–2 trial.ResultsFive hundred and thirty-four of 2,475 trauma patients met the inclusion criteria for TXA administration. Twenty-one patients who received TXA at peripheral hospital prior to their arrival at the level-one trauma centre were excluded from the analysis, and 18 patients were excluded due to missing data. One hundred and thirty-four patients received TXA, representing a compliance rate of 27%. Mean time from arrival to TXA administration was 47 minutes. Compliance increased for those who required massive transfusion and as the number of criteria for TXA administration increased.ConclusionsCompliance with TXA administration to trauma patients with suspected major bleeding was low. Quality improvement strategies aimed at increasing appropriate use of TXA are warranted.
Sensitivity of internal wave energy distribution over seabed corrugations to adjacent seabed features
Authors: Karimpour Farid , Zareei Ahmad , Tchoufag Joël , Alam Mohammad-Reza 
Published: July 2017

Here we show that the distribution of energy of internal gravity waves over a patch of seabed corrugations strongly depends on the distance of the patch to adjacent seafloor features located downstream of the patch. Specifically, we consider the steady state energy distribution due to an incident internal wave arriving at a patch of seabed ripples neighbouring (i) another patch of ripples (i.e. a second patch) and (ii) a vertical wall. Seabed undulations with dominant wavenumber twice as large as overpassing internal waves reflect back part of the energy of the incident internal waves (Bragg reflection) and allow the rest of the energy to transmit downstream. In the presence of a neighbouring topography on the downstream side, the transmitted energy from the patch may reflect back; partially if the downstream topography is another set of seabed ripples or fully if it is a vertical wall. The reflected wave from the downstream topography is again reflected back by the patch of ripples through the same mechanism. This consecutive reflection goes on indefinitely, leading to a complex interaction pattern including constructive and destructive interference of multiply reflected waves as well as an interplay between higher mode internal waves resonated over the topography. We show here that when steady state is reached both the qualitative and quantitative behaviour of the energy distribution over the patch is a strong function of the distance between the patch and the downstream topography: it can increase or decrease exponentially fast along the patch or stay (nearly) unchanged. As a result, for instance, the local energy density in the water column can become an order of magnitude larger in certain areas merely based on where the downstream topography is. This may result in the formation of steep waves in specific areas of the ocean, leading to breaking and enhanced mixing. At a particular distance, the wall or the second patch may also result in a complete disappearance of the trace of the seabed undulations on the upstream and the downstream wave field.
Association between spicy food consumption and lipid profiles in adults: a nationwide population-based study
Authors: Xue Yong , He Tingchao , Yu Kai , Zhao Ai , Zheng Wei , Zhang Yumei , Zhu Baoli 
Published: July 2017

AbstractCVD remains the leading cause of mortality worldwide, with abnormal lipid metabolism as a major risk factor. The aim of this study was to investigate associations between spicy food consumption and serum lipids in Chinese adults. Data were extracted from the 2009 phase of the China Health and Nutrition Survey, consisting of 6774 apparently healthy Chinese adults aged 18–65 years. The frequency of consumption and degree of pungency of spicy food were self-reported, and regular spicy food consumption was assessed using three consecutive 24-h recalls. Total cholesterol, TAG, LDL-cholesterol and HDL-cholesterol in fasting serum were measured. Multilevel mixed-effects models were constructed to estimate associations between spicy food consumption and serum lipid profiles. The results showed that the frequency and the average amount of spicy food intake were both inversely associated with LDL-cholesterol and LDL-cholesterol:HDL-cholesterol ratio (all Pfor trend<0·05) after adjustment for potential confounders and cluster effects. HDL-cholesterol in participants who usually consumed spicy food (≥5 times/week) and who consumed spicy food perceived as moderate in pungency were significantly higher than those who did not (both P<0·01). The frequency and the average amount of spicy food intake and the degree of pungency in spicy food were positively associated with TAG (all Pfor trend<0·05). Spicy food consumption was inversely associated with serum cholesterol and positively associated with serum TAG, and additional studies are needed to confirm the findings as well as to elucidate the potential roles of spicy food consumption in lipid metabolism.
Ensiled Moringa oleifera: an antioxidant-rich feed that improves dairy cattle performance
Authors: COHEN-ZINDER M. , WEINBERG Z. , LEIBOVICH H. , CHEN Y. , ROSEN M. , SAGI G. , ORLOV A. , AGMON R. , YISHAY M. , MIRON J. , SHABTAY A. 
Published: July 2017

SUMMARYMoringa oleifera is a rich source of antioxidants and a promising feed for livestock, due to significant amounts of protein, vitamins, carotenoids and polyphenols, and negligible amounts of anti-nutritional factors. The current study tested whether ensiling would preserve the antioxidant capacity of M. oleifera plants, and assessed whether Moringa silage, fed as a substitute for maize silage, would confer health-promoting traits and affect milk production in dairy cows. To this end, hand-harvested M. oleifera plants were ensiled, with or without molasses and inoculants, in anaerobic jars at room temperature (25 °C) for 37 days. At the end of the storage period the silages were analysed for pH, lactic acid and acetic acid concentrations, aerobic stability, antioxidant capacity, polyphenols and protein content, and tocopherols and carotenoids concentrations. Moringa silages exhibited higher antioxidant capacity compared with fresh and dried Moringa plants, not related to polyphenol content but presumably attributed to accumulation of amino acids and low molecular weight peptides. Based on these findings, a large-scale ensiling protocol was implemented, followed by a feeding trial for dairy cows, in which Moringa silage replaced 263 g maize silage/kg in the diet. Cows fed Moringa silage had higher milk yield and antioxidant capacity and lower milk somatic cell counts compared with controls, during some stages of lactation. These findings imply that ensiling M. oleifera is an appropriate practice by which health and production of dairy cows can be improved.
Truth, Lies, and Concealment: St. Augustine on Mendacious Political Thought
Authors: Russell Jeremiah , Promisel Michael 
Published: July 2017

AbstractThere is disagreement among scholars regarding the mendacity of esoteric writing. Some see it as a necessarily dishonest mode of communication; others argue it does not meet the conditions of lying; others are more nuanced in their assessment. In this article, we seek to resolve this disagreement by offering a systematic analysis of the literary practice in which we argue that there are both truthful and mendacious forms of esoteric writing. In sum, if an author conceals truths from a general audience while still being truthful on the surface of the text or makes it clear that he is being untruthful, he is not lying; yet if an author conceals truths while intentionally being untruthful on the surface, he is lying. Given the parallel ethical structure between esoteric writing and political discourse, we argue that the analysis provided in this article may illuminate the ethical choices made in both written and political statements.
Richard Rorty's Unfulfilled Humanism and the Public/Private Divide
Authors: Ballacci Giuseppe 
Published: July 2017

AbstractRorty's separation between self-creation and political commitment is at the same time one of the pillars of his political theory and one of its most criticized elements. In this paper I offer a novel criticism of this separation, elaborating a comparison between him and the rhetorical-humanistic tradition of Cicero, Quintilian, the Italian Humanists, and Vico. If many have emphasized the deep humanism of Rorty's thought, still unnoticed is the fact that his version of humanism contradicts a basic tenet of that tradition: the idea that the mastery of communicative skills is key to the development of the person both as individual and citizen. As I will show, Rorty's conclusion about the necessity to neatly separate the two realms is in contradiction not only with that tradition but also with the general scope of his own project and the very humanistic picture he himself draws of culture, society, and the intellectuals.
THE SYNTAX-SEMANTICS OF ADJECTIVAL DISTRIBUTION IN ADULT POLISH-SPANISH CHILDHOOD BILINGUALS
Authors: Judy Tiffany 
Published: July 2017

AbstractThe present study examines potential age and microparametric effects in childhood bilinguals (currently adults) in an understudied language pairing, Polish-Spanish. Specifically, a Spanish group (N =28) and a Sequential child bilingual (N =22) and a Simultaneous bilingual (N =8) group living in Misiones, Argentina, completed three experimental tasks assessing their knowledge of the syntactic and syntax-semantic distribution of adjectives. Results show that, despite several semantic differences related to adjective position, both experimental groups demonstrate knowledge of interpretive constraints that fall out from underlying Spanish syntax. Differences predicted as a result of crosslinguistic influence were not evidenced, yet, contrary to Polish and Spanish, the experimental groups accepted ungrammatical postnominal intensional adjectives significantly more than Spanish speakers.
Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
Authors: Mori Munemasa , Hazan Renin , Danielian Paul S. , Mahoney John E. , Li Huijun , Lu Jining , Miller Emily S. , Zhu Xueliang , Lees Jacqueline A. , Cardoso Wellington V. 
Published: July 2017

AbstractAbnormal development of multiciliated cells is a hallmark of a variety of human conditions associated with chronic airway diseases, hydrocephalus and infertility. Multiciliogenesis requires both activation of a specialized transcriptional program and assembly of cytoplasmic structures for large-scale centriole amplification that generates basal bodies. It remains unclear, however, what mechanism initiates formation of these multiprotein complexes in epithelial progenitors. Here we show that this is triggered by nucleocytoplasmic translocation of the transcription factor E2f4. After inducing a transcriptional program of centriole biogenesis, E2f4 forms apical cytoplasmic organizing centres for assembly and nucleation of deuterosomes. Using genetically altered mice and E2F4 mutant proteins we demonstrate that centriole amplification is crucially dependent on these organizing centres and that, without cytoplasmic E2f4, deuterosomes are not assembled, halting multiciliogenesis. Thus, E2f4 integrates nuclear and previously unsuspected cytoplasmic events of centriole amplification, providing new perspectives for the understanding of normal ciliogenesis, ciliopathies and cancer.
AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
Authors: Brechet Aline , Buchert Rebecca , Schwenk Jochen , Boudkkazi Sami , Zolles Gerd , Siquier-Pernet Karine , Schaber Irene , Bildl Wolfgang , Saadi Abdelkrim , Bole-Feysot Christine , Nitschke Patrick , Reis Andre , Sticht Heinrich , Al-Sanna’a Nouriya , Rolfs Arndt , Kulik Akos , Schulte Uwe , Colleaux Laurence , Abou Jamra Rami , Fakler Bernd 
Published: July 2017

AbstractAMPA-type glutamate receptors (AMPARs), key elements in excitatory neurotransmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the endoplasmic reticulum (ER) and lack the core-subunits typical for AMPARs in the plasma membrane. Central components of these ER AMPARs are the proteome constituents FRRS1l (C9orf4) and CPT1c that specifically and cooperatively bind to the pore-forming GluA1-4 proteins of AMPARs. Bi-allelic mutations in the human FRRS1L gene are shown to cause severe intellectual disability with cognitive impairment, speech delay and epileptic activity. Virus-directed deletion or overexpression of FRRS1l strongly impact synaptic transmission in adult rat brain by decreasing or increasing the number of AMPARs in synapses and extra-synaptic sites. Our results provide insight into the early biogenesis of AMPARs and demonstrate its pronounced impact on synaptic transmission and brain function.
Crystal structure of E. coli apolipoprotein N-acyl transferase
Authors: Lu Guangyuan , Xu Yingzhi , Zhang Kai , Xiong Yong , Li He , Cui Lei , Wang Xianping , Lou Jizhong , Zhai Yujia , Sun Fei , Zhang Xuejun C. 
Published: July 2017

AbstractIn Gram-negative bacteria, lipid modification of proteins is catalysed in a three-step pathway. Apolipoprotein N-acyl transferase (Lnt) catalyses the third step in this pathway, whereby it transfers an acyl chain from a phospholipid to the amine group of the N-terminal cysteine residue of the apolipoprotein. Here, we report the 2.6-Å crystal structure of Escherichia coli Lnt. This enzyme contains an exo-membrane nitrilase domain fused to a transmembrane (TM) domain. The TM domain of Lnt contains eight TM helices which form a membrane-embedded cavity with a lateral opening and a periplasmic exit. The nitrilase domain is located on the periplasmic side of the membrane, with its catalytic cavity connected to the periplasmic exit of the TM domain. An amphipathic lid loop from the nitrilase domain interacts with the periplasmic lipid leaflet, forming an interfacial entrance from the lipid bilayer to the catalytic centre for both the lipid donor and acceptor substrates.
The evolution of host-symbiont dependence
Authors: Fisher Roberta M. , Henry Lee M. , Cornwallis Charlie K. , Kiers E. Toby , West Stuart A. 
Published: July 2017

AbstractOrganisms across the tree of life form symbiotic partnerships with microbes for metabolism, protection and resources. While some hosts evolve extreme dependence on their symbionts, others maintain facultative associations. Explaining this variation is fundamental to understanding when symbiosis can lead to new higher-level individuals, such as during the evolution of the eukaryotic cell. Here we perform phylogenetic comparative analyses on 106 unique host–bacterial symbioses to test for correlations between symbiont function, transmission mode, genome size and host dependence. We find that both transmission mode and symbiont function are correlated with host dependence, with reductions in host fitness being greatest when nutrient-provisioning, vertically transmitted symbionts are removed. We also find a negative correlation between host dependence and symbiont genome size in vertically, but not horizontally, transmitted symbionts. These results suggest that both function and population structure are important in driving irreversible dependence between hosts and symbionts.
Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function
Authors: Zhang Chi , Lai Maria B. , Khandan Lavan , Lee Lindsey A. , Chen Zhe , Junge Harald J. 
Published: July 2017

AbstractAngiogenesis and blood–brain barrier formation are required for normal central nervous system (CNS) function. Both processes are controlled by Wnt or Norrin (NDP) ligands, Frizzled (FZD) receptors, and β-catenin-dependent signalling in vascular endothelial cells. In the retina, FZD4 and the ligand NDP are critical mediators of signalling and are mutated in familial exudative vitreoretinopathy. Here, we report that NDP is a potent trigger of FZD4 ubiquitination and induces internalization of the NDP receptor complex into the endo-lysosomal compartment. Inhibition of ubiquitinated cargo transport through the multivesicular body (MVB) pathway using a dominant negative ESCRT (endosomal sorting complexes required for transport) component VPS4 EQ strongly impairs NDP/FZD4 signalling in vitro and recapitulates CNS angiogenesis and blood-CNS-barrier defects caused by impaired vascular β-catenin signalling in mice. These findings provide evidence for an important role of FZD4 endocytosis in NDP/FZD4 signalling and in CNS vascular biology and disease.
Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer
Authors: O’Flanagan Ciara H. , Rossi Emily L. , McDonell Shannon B. , Chen Xuewen , Tsai Yi-Hsuan , Parker Joel S. , Usary Jerry , Perou Charles M. , Hursting Stephen D. 
Published: July 2017

AbstractThe vast majority of cancer-related deaths are due to metastatic disease, whereby primary tumor cells disseminate and colonize distal sites within the body. Triple negative breast cancer typically displays aberrant Wnt signaling, lacks effective targeted therapies, and compared with other breast cancer subtypes, is more likely to recur and metastasize. We developed a Wnt-driven lung metastasis model of triple negative breast cancer (metM-Wntlung) through serial passaging of our previously described, nonmetastatic, claudin-low M-Wnt cell line. metM-Wntlung cells displayed characteristics of epithelial-to-mesenchymal transition (e.g., increased invasiveness) with some re-epithealization (e.g., increased adhesion, tight colony formation, increased E-cadherin expression, and decreased Vimentin and Fibronectin expression). When orthotopically transplanted into syngeneic mice, metM-Wntlung cells readily formed tumors and metastasized in vivo, and tumor growth and metastasis were enhanced in obese mice compared with non-obese mice. Gene expression analysis revealed several genes and pathways altered in metM-Wntlung cells compared with M-Wnt cells, including multiple genes associated with epithelial-to-mesenchymal transition, energy metabolism and inflammation. Moreover, obesity caused significant transcriptomic changes, especially in metabolic pathways. Metabolic flux analyses showed greater metabolic plasticity, with heightened mitochondrial and glycolytic energetics in metM-Wntlung cells relative to M-Wnt cells. Similar metabolic profiles were found in a second triple negative breast cancer progression series, M6 and M6C cells. These findings suggest that metabolic reprogramming is a feature of metastatic potential in triple negative breast cancer. Thus, targeting metastases-associated metabolic perturbations may represent a novel strategy for reducing the burden of metastatic triple negative breast cancer, particularly in obese women.
Comparative phylogenetic analyses of recombinant noroviruses based on different protein-encoding regions show the recombination-associated evolution pattern
Authors: Xue Liang , Wu Qingping , Dong Ruimin , Cai Weicheng , Wu Haoming , Chen Moutong , Chen Gang , Wang Juan , Zhang Jumei 
Published: July 2017

AbstractNoroviruses are the major cause of acute gastroenteritis worldwide, and recombination is recognized as the important mechanism for its continuous emergence. In this study, for the common GII.P12 and GII.3 recombinants, phylogenetic relationships based on different proteins in three ORFs were comparatively analyzed, focusing on the influence of intergenic recombination. By using newly designed primers, genomes of two GII.P12/GII.3 Guangzhou recombinants were firstly amplified. Combined with other reported sequences of GII.P12_ORF1 (n = 20), GII.3_ORF2 (n = 131), GII.3_ORF3 (n = 36), all GII.P12 and GII.3 strains could be divided into 6, 8, and 7 clusters based on different ORFs, which showed an obvious recombination-associated and temporally sequential evolution pattern (with the exception of GII.P12/GII.13 recombinants). Based on multiple alignments, 126 informative sites were identified in three ORFs (44, 54, and 28), and four proteins (p48, p22, VP1, and VP2) were found under positive selection. Furthermore, by using homology modeling, predicted epitopes were mapped on the P proteins of seven GII.3 representative strains, without one (Epi: 353–361) specific to the GII.4 VA387 strain. In summary, via the genome analyses, phylogenetic relationships of GII.P12 and GII.3 recombinants based on the different proteins presented a special temporally sequential evolution process associated with their recombinant types.
Material-Device-Circuit Co-optimization of 2D Material based FETs for Ultra-Scaled Technology Nodes
Authors: Agarwal Tarun kumar , Soree Bart , Radu Iuliana , Raghavan Praveen , Iannaccone Giuseppe , Fiori Gianluca , Dehaene Wim , Heyns Marc 
Published: July 2017

AbstractTwo-dimensional (2D) material based FETs are being considered for future technology nodes and high performance logic applications. However, a comprehensive assessment of 2D material based FETs has been lacking for high performance logic applications considering appropriate system level figure-of-merits (FOMs) e.g. delay, and energy-delay product. In this paper, we present guidelines for 2D material based FETs to meet sub-10 nm high performance logic requirements focusing on material requirement, device design, energy-delay optimization for the first time. We show the need for 2D materials with smaller effective mass in the transport direction and anisotropicity to meet the performance requirement for future technology nodes. We present novel device designs with one such 2D material (monolayer black-phosphorus) to keep Moore’s alive for the HP logic in sub-5 nm gate length regime. With these device proposals we show that below 5 nm gate lengths 2D electrostatistics arising from gate stack design becomes more of a challenge than direct source-to-drain tunneling for 2D material-based FETs. Therefore, it is challenging to meet both delay and energy-delay requirement in sub-5 nm gate length regime without scaling both supply voltage (V
DD
) and effective-oxide-thickness (EOT) below 0.5 V and 0.5 nm respectively.