bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of sleep restriction on local immune response and skin barrier restoration with and without “multinutrient” nutrition intervention
Authors: Smith Tracey J. , Wilson Marques , Karl J. Philip , Orr Jeb , Smith Carl , Cooper Adam , Heaton Kristin , Young Andrew J. , Montain Scott J. 
Published: September 2017

Systemic immune function is impaired by sleep restriction. However, the impact of sleep restriction on local immune responses and to what extent any impairment can be mitigated by nutritional supplementation is unknown. We assessed the effect of 72-h sleep restriction (2-h nightly sleep) on local immune function and skin barrier restoration of an experimental wound, and determined the influence of habitual protein intake (1.5 g·kg−1·day−1) supplemented with arginine, glutamine, zinc sulfate, vitamin C, vitamin D3, and omega-3 fatty acids compared with lower protein intake (0.8 g·kg−1·day−1) without supplemental nutrients on these outcomes. Wounds were created in healthy adults by removing the top layer of less than or equal to eight forearm blisters induced via suction, after adequate sleep (AS) or 48 h of a 72-h sleep restriction period (SR; 2-h nightly sleep). A subset of participants undergoing sleep restriction received supplemental nutrients during and after sleep restriction (SR+). Wound fluid was serially sampled 48 h postblistering to assess local cytokine responses. The IL-8 response of wound fluid was higher for AS compared with SR [area-under-the-curve (log10), 5.1 ± 0.2 and 4.9 ± 0.2 pg/ml, respectively; P = 0.03]; and both IL-6 and IL-8 concentrations were higher for SR+ compared with SR ( P < 0.0001), suggestive of a potentially enhanced early wound healing response. Skin barrier recovery was shorter for AS (4.2 ± 0.9 days) compared with SR (5.0 ± 0.9 days) ( P = 0.02) but did not differ between SR and SR+ ( P = 0.18). Relatively modest sleep disruption delays wound healing. Supplemental nutrition may mitigate some decrements in local immune responses, without detectable effects on wound healing rate. NEW & NOTEWORTHY The data herein characterizes immune function in response to sleep restriction in healthy volunteers with and without nutrition supplementation. We used a unique skin wound model to show that sleep restriction delays skin barrier recovery, and nutrition supplementation attenuates decrements in local immune responses produced by sleep restriction. These findings support the beneficial effects of adequate sleep on immune function. Additional studies are necessary to characterize practical implications for populations where sleep restriction is unavoidable.
A Combination RNAi-Chemotherapy Layer-by-Layer Nanoparticle for Systemic Targeting of KRAS/P53 with Cisplatin to Treat Non–Small Cell Lung Cancer
Authors: Gu Li , Deng Zhou J. , Roy Sweta , Hammond Paula T. 
Published: September 2017

AbstractPurpose: Mutation of the Kirsten ras sarcoma viral oncogene homolog (KRAS) and loss of p53 function are commonly seen in patients with non–small cell lung cancer (NSCLC). Combining therapeutics targeting these tumor-defensive pathways with cisplatin in a single-nanoparticle platform are rarely developed in clinic.Experimental Design: Cisplatin was encapsulated in liposomes, which multiple polyelectrolyte layers, including siKRAS and miR-34a were built on to generate multifunctional layer-by-layer nanoparticle. Structure, size, and surface charge were characterized, in addition to in vitro toxicity studies. In vivo tumor targeting and therapy was investigated in an orthotopic lung cancer model by microCT, fluorescence imaging, and immunohistochemistry.Results: The singular nanoscale formulation, incorporating oncogene siKRAS, tumor-suppressor stimulating miR-34a, and cisplatin, has shown enhanced toxicity against lung cancer cell line, KP cell. In vivo, systemic delivery of the nanoparticles indicated a preferential uptake in lung of the tumor-bearing mice. Efficacy studies indicated prolonged survival of mice from the combination treatment.Conclusions: The combination RNA-chemotherapy in an LbL formulation provides an enhanced treatment efficacy against NSCLC, indicating promising potential in clinic. Clin Cancer Res; 23(23); 7312–23. ©2017 AACR.
D-Dimer in African Americans
Authors: Raffield Laura M. , Zakai Neil A. , Duan Qing , Laurie Cecelia , Smith Joshua D. , Irvin Marguerite R. , Doyle Margaret F. , Naik Rakhi P. , Song Ci , Manichaikul Ani W. , Liu Yongmei , Durda Peter , Rotter Jerome I. , Jenny Nancy S. , Rich Stephen S. , Wilson James G. , Johnson Andrew D. , Correa Adolfo , Li Yun , Nickerson Deborah A. , Rice Kenneth , Lange Ethan M. , Cushman Mary , Lange Leslie A. , Reiner Alex P. 
Published: September 2017

Objective—
Plasma levels of the fibrinogen degradation product D-dimer are higher among African Americans (AAs) compared with those of European ancestry and higher among women compared with men. Among AAs, little is known of the genetic architecture of D-dimer or the relationship of D-dimer to incident cardiovascular disease.

Approach and Results—

We measured baseline D-dimer in 4163 AAs aged 21 to 93 years from the prospective JHS (Jackson Heart Study) cohort and assessed association with incident cardiovascular disease events. In participants with whole genome sequencing data (n=2980), we evaluated common and rare genetic variants for association with D-dimer. Each standard deviation higher baseline D-dimer was associated with a 20% to 30% increased hazard for incident coronary heart disease, stroke, and all-cause mortality. Genetic variation near
F3
was associated with higher D-dimer (rs2022030, β=0.284,
P
=3.24×10
–11
). The rs2022030 effect size was nearly 3× larger among women (β=0.373,
P
=9.06×10
–13
) than among men (β=0.135,
P
=0.06;
P
interaction =0.009). The sex by rs2022030 interaction was replicated in an independent sample of 10 808 multiethnic men and women (
P
interaction =0.001). Finally, the African ancestral sickle cell variant (
HBB
rs334) was significantly associated with higher D-dimer in JHS (β=0.507,
P
=1.41×10
–14
), and this association was successfully replicated in 1933 AAs (
P
=2.3×10
–5
).

Conclusions—

These results highlight D-dimer as an important predictor of cardiovascular disease risk in AAs and suggest that sex-specific and African ancestral genetic effects of the
F3
and
HBB
loci contribute to the higher levels of D-dimer among women and AAs.
Reciprocal Interference Between Audition and Touch in the Perception of Duration
Authors: Villanueva Lia , Zampini Massimiliano 
Published: September 2017

Audition and touch interact with one another and share a number of similarities; however, little is known about their interplay in the perception of temporal duration. The present study intended to investigate whether the temporal duration of an irrelevant auditory or tactile stimulus could modulate the perceived duration of a target stimulus presented in the other modality (i.e., tactile or auditory) adopting both a between-participants (Experiment 1) and a within-participants (Experiment 2) experimental design. In a two-alternative forced-choice task, participants decided which of two events in a target modality was longer. The simultaneously distractor stimuli were presented with a duration that was either congruent or incongruent to the target’s. Results showed that both the auditory and tactile modalities affected duration judgments in the incongruent condition, decreasing performance in both experiments. Moreover, in Experiment 1, the tactile modality enhanced the perception of auditory stimuli in the congruent condition, but audition did not facilitate performance for the congruent condition in the tactile modality; this tactile enhancement of audition was not found in Experiment 2. To the best of our knowledge, this is the first study documenting audiotactile interactions in the perception of duration, and suggests that audition and touch might modulate one another in a more balanced manner, in contrast to audiovisual pairings. The findings support previous evidence as to the shared links and reciprocal influences when audition and touch interact with one another.
A New Interpretation of Vortex-Split Sudden Stratospheric Warmings in Terms of Equilibrium Statistical Mechanics
Authors: Yasuda Yuki , Bouchet Freddy , Venaille Antoine 
Published: September 2017

Abstract
Vortex-split sudden stratospheric warmings (S-SSWs) are investigated by using the Japanese 55-year Reanalysis, a spherical barotropic quasigeostrophic (QG) model, and equilibrium statistical mechanics. The statistical mechanics theory predicts a large-scale steady state as the most probable outcome of turbulent stirring, and such a state can be computed without describing all the details of the dynamics. The theory is applied to a disk domain that is modeled on the polar cap north of 45°N in the stratosphere. The equilibrium state is obtained by computing the maximum of an entropy functional. In the range of parameters relevant to the winter stratosphere, this state is anticyclonic. By contrast, cyclonic states are quasi-stationary states corresponding to saddle points of the entropy functional. These results indicate that the mean state of the stratosphere associated with the polar vortex is not close to an equilibrium state but to a quasi-stationary state. The theoretical calculations are compared with the results of a quasi-static experiment in which a wavenumber-2 topographic amplitude is increased linearly and slowly with time. The results suggest that the S-SSW can be qualitatively interpreted as the transition from the cyclonic quasi-stationary state toward the anticyclonic equilibrium state. The polar vortex splits during the transition toward the equilibrium state.
Procedural Justice, Job Satisfaction and Organizational Citizenship Behaviour: Mediating Role of Organizational Trust—Indian Tourism Industry Study
Authors: Yadav Lalit Kumar , Gupta Pawan 
Published: September 2017

This study attempts to understand job satisfaction (JS) and organizational citizenship behaviour (OCB) in relation to procedural justice (PJ). It also studies the mechanism through which PJ is likely to influence the dependent variables. On the basis of existing literature, organizational trust is identified as the mediating instrument through which PJ may affect JS and OCB. A survey-based design was used to collect data from 204 employees in the National Capital Region of Delhi. The respondents were working in organizations that broadly encompass the tourism industry. Correlation, regression and hierarchical multiple regression were used to test the model in the study. The mediation model was also tested using the bias-corrected percentile method with 5000 bootstrap samples. The results of the study corroborated with the previous findings and the stated hypotheses, with the exception that organizational trust was found not to mediate the relation between PJ and OCB. Some significant implications for managers and organizations can be gauged from this study. Managers must work towards establishing fair procedures in all aspects of organizational functioning. They should also decipher the attributes of organizational trust which are perceived as valuable by the employees.
Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke
Authors: Yamaguchi Susumu , Horie Nobutaka , Satoh Katsuya , Ishikawa Takeshi , Mori Tsuyoshi , Maeda Hajime , Fukuda Yuhtaka , Ishizaka Shunsuke , Hiu Takeshi , Morofuji Yoichi , Izumo Tsuyoshi , Nishida Noriyuki , Matsuo Takayuki 
Published: September 2017

Cell transplantation therapy offers great potential to improve impairments after stroke. However, the importance of donor age on therapeutic efficacy is unclear. We investigated the regenerative capacity of transplanted cells focusing on donor age (young vs. old) for ischaemic stroke. The quantities of human mesenchymal stem cell (hMSC) secreted brain-derived neurotrophic factor in vitro and of monocyte chemotactic protein-1 at day 7 in vivo were both significantly higher for young hMSC compared with old hMSC. Male Sprague-Dawley rats subjected to transient middle cerebral artery occlusion that received young hMSC (trans-arterially at 24 h after stroke) showed better behavioural recovery with prevention of brain atrophy compared with rats that received old hMSC. Histological analysis of the peri-infarct cortex showed that rats treated with young hMSC had significantly fewer microglia and more vessels covered with pericytes. Interestingly, migration of neural stem/progenitor cells expressing Musashi-1 positively correlated with astrocyte process alignment, which was more pronounced for young hMSC. Aging of hMSC may be a critical factor that affects cell therapy outcomes, and transplantation of young hMSC appears to provide better functional recovery through anti-inflammatory effects, vessel maturation, and neurogenesis potentially by the dominance of trophic factor secretion.
Acceptance of home blood glucose monitoring by owners of recently diagnosed diabetic cats and impact on quality of life changes in cat and owner
Authors: Hazuchova Katarina , Gostelow Ruth , Scudder Christopher , Forcada Yaiza , Church David B , Niessen Stijn JM 
Published: September 2017

Objectives This study aimed to evaluate the acceptance of home blood glucose monitoring (HBGM) by owners of recently diagnosed diabetic cats, and the impact of choosing HBGM on the quality of life (QoL) changes of cat and owner, in addition to glycaemic changes during 6 months of follow-up. Methods Owners of cats diagnosed with diabetes mellitus (DM) and treated with insulin for 6–20 weeks were divided into an HBGM group and a non-HBGM group, based on their ability and willingness to perform HBGM after a standardised instruction session. The HBGM acceptance level and reasons for acceptance failure were documented; a questionnaire evaluated owners’ experiences. For the following 6 months, changes in QoL, measured using the validated DIAQoL-pet quantification tool, and changes in glycaemic control parameters (clinical signs, serum fructosamine, blood glucose curve average/minimal/maximal/pre-insulin blood glucose) were compared between HBGM and non-HBGM groups at months 1, 3 and 6, as well as within the groups between baseline and months 1, 3 and 6. Results Thirty-eight cats were enrolled; 28 (74%) entered the HBGM group. There was no significant difference between groups in overall DIAQoL-pet score or glycaemic control parameters at any time point apart from the maximal blood glucose at month 6 (lower in the HBGM group). However, the DIAQoL-pet score, including indicators of owner worry about DM, worry about hypoglycaemia and costs, as well as glycaemic parameters, improved at all time points within the HBGM group but not within the non-HBGM group. Remission occurred in 9/28 (32%) HBGM group cats and 1/10 (10%) non-HBGM group cats ( P = 0.236). Conclusions and relevance HBGM was adopted successfully by most diabetic cat owners. Despite the extra task, positive changes in QoL parameters occurred in the HBGM group and not in the non-HBGM group. Although no difference was found in glycaemic control between the HBGM and non-HBGM groups during the 6 months of follow-up, significant glycaemic improvements were documented in the HBGM group.
Circulating lymphocyte levels and relationship with infection status in patients with relapsing–remitting multiple sclerosis treated with daclizumab beta
Authors: Giovannoni Gavin , Wiendl Heinz , Turner Benjamin , Umans Kimberly , Mokliatchouk Oksana , Castro-Borrero Wanda , Greenberg Steven J , McCroskery Peter , Giannattasio Giorgio 
Published: September 2017

Background: Reversible lymphocyte count reductions have occurred following daclizumab beta treatment for relapsing–remitting multiple sclerosis. Objective: To analyse total and differential lymphocyte levels and relationship with infection status. Methods: In DECIDE, blood samples were collected at 12-week intervals from daclizumab beta- ( n = 919) or intramuscular interferon beta-1a–treated ( n = 922) patients. Infections/serious infections were assessed proximate to grade 2/3 lymphopenia or low CD4+/CD8+ T-cell counts. Total safety population (TSP) data were additionally analysed from the entire clinical development programme ( n = 2236). Results: Over 96 weeks in DECIDE, mean absolute lymphocyte count (ALC), CD4+ and CD8+ T-cell counts decreased <10% (7.1% vs 1.6%, 9.7% vs 2.0%, 9.3% vs 5.9%: daclizumab beta vs interferon beta-1a, respectively); shifts to ALC below lower limit of normal occurred in 13% versus 15%, respectively. Grade 3 lymphopenia was uncommon (TSP: <1%) and transient. Lymphocyte changes generally occurred within 24 weeks after treatment initiation and were reversible within 12 weeks of discontinuation. In DECIDE, mean CD4+/CD8+ T-cell counts were similar regardless of infection status. TSP data were consistent with DECIDE. Conclusion: When observed, ALC and CD4+/CD8+ T-cell count decreases in daclizumab beta–treated patients were generally mild-to-modest, reversible upon treatment discontinuation and not associated with increased risk of infections, including opportunistic infections.
Fatigue in multiple sclerosis: The contribution of resting-state functional connectivity reorganization
Authors: Bisecco Alvino , Nardo Federica Di , Docimo Renato , Caiazzo Giuseppina , d’Ambrosio Alessandro , Bonavita Simona , Capuano Rocco , Sinisi Leonardo , Cirillo Mario , Esposito Fabrizio , Tedeschi Gioacchino , Gallo Antonio 
Published: September 2017

Objectives: To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and of sensorimotor network (SMN) network in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) and without fatigue(NF). Methods: In all, 59 RRMS patients and 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including resting-state fMRI (RS-fMRI). Functional connectivity of the DMN and SMN was evaluated by independent component analysis (ICA). A linear regression analysis was performed to explore whether fatigue was mainly driven by changes observed in the DMN or in the SMN. Regional gray matter atrophy was assessed by voxel-based morphometry (VBM). Results: Compared to HC, F-MS patients showed a stronger RS-FC in the posterior cingulate cortex (PCC) and a reduced RS-FC in the anterior cingulated cortex (ACC) of the DMN. F-MS patients, compared to NF-MS patients, revealed (1) an increased RS-FC in the PCC and a reduced RS-FC in the ACC of the DMN and (2) an increased RS-FC in the primary motor cortex and in the supplementary motor cortex of the SMN. The regression analysis suggested that fatigue is mainly driven by RS-FC changes of the DMN. Conclusions: Fatigue in RRMS is mainly associated to a functional rearrangement of non-motor RS networks.
Intraoperative Gutter Leaks That Merit Our Attention
Authors: Tanious Adam , Wooster Mathew , Giarelli Marcelo , Armstrong Paul A. , Back Martin R. , Shames Murray L. 
Published: September 2017

Introduction: The natural history and potential morbidity of gutter endoleaks are unclear. We present our experience with intraoperative gutter endoleaks and strategies to determine which of these require intervention. Methods: This is a retrospective review of all patients treated with parallel stent grafts from January 2010 to September 2015. We reviewed all operative records and intraoperative angiograms as well as all postoperative imaging and secondary interventions. All gutter leaks were classified as low-flow/nonsac-enhancing gutter endoleaks or high-flow/sac-enhancing gutter endoleaks. Adjunctive interventions to manage the gutter leaks were noted, as were all subsequent interventions for gutter leak and endoleak management. Results: Seventy-eight patients had 144 parallel stents placed over a 5-year period with an average of 1.8 stents per patient. Twenty-eight patients (36%) had gutter endoleaks diagnosed intraoperatively. Seventeen patients had adjunctive procedures to reduce gutter leaks prior to leaving the operating room (OR). Patients selected for treatment had gutters filling early during completion angiography and/or contrast enhancement of the aneurysm sac. Twenty-two patients (28%) left the OR with low-flow/delayed/nonsac-enhancing gutter endoleaks. At 30 days, a total of 6 persistent gutter endoleaks were diagnosed on computed tomographic angiography. This gives a 73% rate of resolution for low-flow/nonaneurysm sac-enhancing endoleaks. There were 2 de novo endoleaks not detected at the index procedure diagnosed at 6-month follow-up. Of the 8 total postoperative endoleaks, 5 required additional intervention with a 100% success rate. Multivariate analysis revealed that the only significant predictor of having a postoperative endoleak is leaving the OR with an endoleak. Conclusions: Intraoperative treatment of gutter endoleaks has an acceptable rate of resolution. It does have a high rate of converting high-flow endoleaks to low-flow endoleaks. Low-flow/nonsac-enhancing gutter endoleaks have a high rate of spontaneous resolution. Intraoperative gutter endoleaks are not predictive of future aneurysm sac growth.
Multi-morbidity: A patient perspective on navigating the health care system and everyday life
Authors: Ørtenblad Lisbeth , Meillier Lucette , Jønsson Alexandra R 
Published: September 2017

Objective The importance of everyday life when managing the burden of treatment is rarely studied. This article explores the burden of treatment among people with multi-morbidity by investigating the tension between everyday life and the health care system. Method This was an ethnographic study using individual interviews and participant-observations. An inductive analytical approach was applied, moving from observations and results to broader generalisations. Results People with multi-morbidity experience dilemmas related to their individual priorities in everyday life and the management of their treatment burdens. Dilemmas were identified within three domains: family and social life; work life; agendas and set goals in appointments with health professionals. Individual resources and priorities in everyday life play a dominant role in resolving dilemmas and navigating the tension between everyday life and the health care system. Discussion People with multi-morbidity are seldom supported by health professionals in resolving the dilemmas they must face. This study suggests an increased focus on patient-centredness and argues in favour of planning health care through cooperation between health professionals and people with multi-morbidity in a way that integrates both health and everyday life priorities.