bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship between Abdominal Aortic Aneurysm Wall Compliance, Maximum Diameter and Growth Rate
Authors: Wilson K. , Whyman M. , Hoskins P. , Lee A. J. , Bradbury A. W. , Fowkes F. G. R. , Ruckley C. V. 
Published: September 2024

Aim: Aortic compliance as measured by the pressure—strain elastic modulus (Ep) and stiffness (β), may allow a more precise estimate of rupture risk. The aim of this study was to determine the relationships between compliance, maximal aneurysm diameter and growth rate. Methods: Sixty abdominal aortic aneurysm patients of median age 73 years, were studied. Growth rate was derived from repeat ultrasound scans obtained over a median period of 21 months (range 6–48). At the end of follow-up, patients underwent measurement of maximum aortic diameter, Ep and β using the Diamove echo-tracking system. Results: Growth rate correlated positively ( r = 0.6, P < 0.01) with maximum diameter on entry to the study There was a positive correlation between mean arterial pressure and Ep ( r = 0.3. P = 0.03), but not between mean arterial pressure and β ( r = 0.8, P = 0.61). A positive correlation was found between final maximum diameter and Ep ( r = 0.22, P = 0.04) but not β ( r = 0.16. P = 0.11). There was no significant relationship between growth rate and Ep or β. Conclusion: Large aneurysms tended to be less compliant. Within a population of abdominal aortic aneurysm of similar maximum diameter there was a 10-fold variation in Ep and β. Compliance and growth rate were not related. If aortic compliance is related to risk of rupture then this predictive information is likely to be largely independent of that currently obtained from size and growth rate.
Arteriography in Chronic Renal Failure: A Case for Carbon Dioxide
Authors: Fitridge R. A. , Petrucco M. , Dunlop C. M. , Thompson M. M. , Sebben R. A. 
Published: September 2024

Purpose: The aim of this study was to assess the utilisation of carbon dioxide arteriography, performed with a simple injection system, as the imaging technique of choice in patients with chronic renal failure. Methods: Patients with chronic renal impairment who required arterial imaging or intervention were recruited for carbon dioxide angiography. Demographic data were prospectively recorded and pre- and post-arteriogram renal function was quantified. Radiographic images were graded by an independent radiologist. Results: Twenty-eight patients underwent renal or aorto-femoral studies with only one failure. There were no cases of contrast-induced nephropathy. Twenty-two of the films (79%) were graded as excellent or good, four as acceptable and two were considered to be poor (non-diagnostic). Conclusions: This study has demonstrated that carbon dioxide angiography is a safe and clinically effective procedure in patients with chronic renal failure.
Reckoning with rights: the Voice Referendum
Authors: Hunter Ernest 
Published: September 2024

Objective Many Aboriginal and Torres Strait Islander Australians are dismayed by the rejection of the 2023 Voice Referendum and its amplification of social divisions. This article considers a recent article in Australasian Psychiatry in which matters of motivation, process and outcome are raised that provides the scaffolding to explore these issues. Conclusions The breakdown of bipartisan political support and subsequent politicisation of the Referendum process resulted in claims regarding the reasons for and consequences of the Referendum that were not consistent with the process leading to the Uluru Statement. The outcome has been socially divisive and a cause of significant distress for many Aboriginal and Torres Strait Islander Australians, the majority of whom voted in support of the Voice.
Adverse event profiles of CDK4/6 inhibitors: data mining and disproportionality analysis of the FDA adverse event reporting system
Authors: Shen Jun , Luo Pingli , Xu Jianmei 
Published: September 2024

Background: Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors are targeted therapies designed to selectively block CDK4/6, crucial regulators of the cell cycle. These inhibitors play a pivotal role in restoring cell cycle control, particularly in breast cancer cases marked by abnormal CDK regulation, ultimately inhibiting uncontrolled cell division and tumor growth. Objectives: This analysis aimed to comprehensively examine adverse effects in CDK4/6 inhibitors using the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. Design: Disproportionality analysis was conducted to analyze the adverse event (AE) reports related to CDK4/6 inhibitor submitted to the FAERS database. Methods: We collected AE reports regarding palbociclib, ribociclib, abemaciclib, trilaciclib, and dalpiciclib submitted to the FAERS from 2015Q1 to 2023Q1. We used the system organ class and the Standardized MedDRA Query to perform a comprehensive search for AEs at the preferred term (PT) level, using case reports as our data source. After removing duplicate reports, we performed disproportionality analysis and sensitivity analysis to identify safety signals. Results: A total of 85,635 reports encompassing 280,211 AEs were extracted for analysis. Among 3681 scrutinized PTs, approximately 484 were detected as statistically significant signals associated with CDK4/6 inhibitors. It was noteworthy that palbociclib and ribociclib had comparable safety profiles, whereas abemaciclib exhibited distinctive safety patterns. Notably, our analysis found novel safety signals linked to CDK4/6 inhibitors, including nail-related disorders such as onychoclasis, nail disorder, and nail discoloration, and psychiatric concerns, including eating disorders and emotional disorder. Conclusion: Overall, the present study identified several new safety signals of CDK4/6 inhibitors, as well as differences among various drugs within the CDK4/6 category, through the use of the FDA FAERS, which deserve more careful monitoring in the clinic.
Guidelines or mindlines? – implementing a new CKD guideline in German primary care
Authors: Laker Konrad , Bothe Tim , Ebert Natalie , Heintze Christoph , Schaeffner Elke , Krüger Karen 
Published: September 2024

Abstract
Background
The development of clinical guidelines aimed at GPs is a key strategy to improving the management of chronic kidney disease (CKD). In 2019, the first CKD guideline aimed specifically at GPs practicing in Germany was published by the German College of General Practitioners and Family Physicians (DEGAM.)

Aims
The aim of this study is to identify the barriers and enablers for the implementation of this guideline. The results of this project, together with quantitative evaluation against quality indicators for CKD in primary care will inform an update to the guideline.

Methods
We performed 17 semi-structured interviews with GPs practicing in Berlin and Brandenburg. Transcripts were analysed using qualitative content analysis as described by Mayring.

Results
We found that the perception of low clinical priority of CKD compared to other chronic diseases, opportunity cost of using guidelines, as well as poor patient understanding were significant barriers. GPs expressed that improved graphic design or integration of guideline recommendations in clinical decision support systems were enabling factors. Clinical problems concerning CKD were mostly solved by recourse to informal communication with specialists. GPs reported that they rarely consulted CKD guidelines as an aide to clinical decision making.

Conclusion
The most significant barrier to use was that guidelines were not used as step-by-step decision aide in consultations with patients. Our analysis suggests that informal contact between primary and secondary care is significant conduit for evidence-based information on CKD in German primary care. Implementation projects should support the development of these relationships.
Detection of hepatocellular carcinoma feeding vessels: MDCT angiography with 3D reconstruction versus digital subtraction angiography
Authors: Ahmed Ramy M. , Ali Wageeh A. , AbdelHakam Ahmed M. , Ahmed Sayed H. 
Published: September 2024

Abstract
Background
Accurate detection of Hepatocellular carcinoma (HCC) feeding vessels during transcatheter arterial chemoembolization (TACE) is important for an effective treatment, while limiting non-target embolization. This study aimed to investigate the feasibility and accuracy of pre-TACE three dimensional (3D) CT angiography for tumor-feeding vessels detection compared to DSA.

Methods
Sixty-nine consecutive patients referred for TACE from May 2022 to May 2023 were included. (3D) CT images were reconstructed from the pre-TACE diagnostic multiphasic contrast enhanced CT images and compared with non-selective digital subtraction angiography (DSA) images obtained during TACE for detection of HCC feeding vessels. A “Ground truth” made by consensus between observers after reviewing all available pre-TACE CT images, and DSA and CBCT images during TACE to detect the true feeding vessels was the gold standard. Sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), accuracy and ROC curve with AUC were calculated for each modality and compared.

Results
A total of 136 active HCCs were detected in the 69 consecutive patients included in the study. 185 feeding arteries were detected by 3D CT and DSA and included in the analysis. 3D CT detection of feeding arteries revealed mean sensitivity, specificity, PPV, NPV and accuracy of 91%, 71%, 98%, 36%, and 90%, respectively, with mean AUC = 0.81. DSA detection of feeding arteries revealed mean sensitivity, specificity, PPV, NPV, and accuracy of 80%, 58%, 96.5%, 16.5% and 78%, respectively, with mean AUC = 0.69.

Conclusions
Pre-TACE 3D CT angiography has shown promise in improving the detection of HCC feeding vessels compared to DSA. However, further studies are required to confirm these findings across different clinical settings and patient populations.

Trial registration
This study was prospectively registered at Clinicaltrials.gov with ID NCT05304572; Date of registration: 2-4-2022.
Paediatric mass casualty response through the lens of Functional Resonance Analytical Methodology- lessons learned
Authors: MacKinnon R. J. , Slater D. , Jenner R. , Stenfors T. , Kennedy C. , Härenstam K. P. 
Published: September 2024

Abstract
Background
Mass Casualty Incidents are rare but can significantly stress healthcare systems. Functional Resonance Analytical Methodology (FRAM) is a systematic approach to model and explore how complex systems adapt to variations and to understand resilient properties in the face of perturbations. The aim of this study was to use FRAM to create a model of a paediatric trauma system during the initial response to the Manchester Arena Attack to provide resilience-based insights for the management of future Mass Casualty Incidents (MCI).

Methods
Qualitative interviews in the immediate aftermath of a terrorist bombing, were followed up with further in-depth probing of subject matter experts to create a validated and verified FRAM model. This model was compared with real incident data, then simplified for future studies.

Results
A Work As Imagined (WAI) model of how a paediatric emergency department provided resilient healthcare for MCI patients from reception and resuscitation to definitive care is presented. A focused model exploring the pathway for the most severely injured patients that will facilitate the simulation of a myriad of potential emergency preparedness resilience response scenarios is also presented.

Conclusions
The systematic approach undertaken in this study has produced a model of a paediatric trauma system during the initial response to the Manchester Arena Attack, providing key insights on how a resilient performance was sustained. This modelling may provide an important step forward in the preparedness and planning for future MCIs.
On-treatment biopsies to predict response to neoadjuvant chemotherapy for breast cancer
Authors: Sinn Bruno Valentin , Sychra Katharina , Untch Michael , Karn Thomas , van Mackelenbergh Marion , Huober Jens , Schmitt Wolfgang , Marmé Frederik , Schem Christian , Solbach Christine , Stickeler Elmar , Tesch Hans , Fasching Peter A. , Schneeweiss Andreas , Müller Volkmar , Holtschmidt Johannes , Nekljudova Valentina , Loibl Sibylle , Denkert Carsten 
Published: September 2024

Abstract
Background
Patients with pathologic complete response (pCR) to neoadjuvant chemotherapy for invasive breast cancer (BC) have better outcomes, potentially warranting less extensive surgical and systemic treatments. Early prediction of treatment response could aid in adapting therapies.

Methods
On-treatment biopsies from 297 patients with invasive BC in three randomized, prospective neoadjuvant trials were assessed (GeparQuattro, GeparQuinto, GeparSixto). BC quantity, tumor-infiltrating lymphocytes (TILs), and the proliferation marker Ki-67 were compared to pre-treatment samples. The study investigated the correlation between residual cancer, changes in Ki-67 and TILs, and their impact on pathologic complete response (pCR) and disease-free survival (DFS).

Results
Among the 297 samples, 138 (46%) were hormone receptor-positive (HR+)/human epidermal growth factor 2-negative (HER2−), 87 (29%) were triple-negative (TNBC), and 72 (24%) were HER2+. Invasive tumor cells were found in 70% of on-treatment biopsies, with varying rates across subtypes (HR+/HER2−: 84%, TNBC: 62%, HER2+: 51%; p < 0.001). Patients with residual tumor on-treatment had an 8% pCR rate post-treatment (HR+/HER2−: 3%, TNBC: 19%, HER2+: 11%), while those without any invasive tumor had a 50% pCR rate (HR+/HER2−: 27%; TNBC: 48%, HER2+: 66%). Sensitivity for predicting residual disease was 0.81, with positive and negative predictive values of 0.92 and 0.50, respectively. Increasing TILs from baseline to on-treatment biopsy (if residual tumor was present) were linked to higher pCR likelihood in the overall cohort (OR 1.034, 95% CI 1.013–1.056 per % increase; p = 0.001) and with a longer DFS in TNBC (HR 0.980, 95% CI 0.963–0.997 per % increase; p = 0.026). Persisting or increased Ki-67 was associated with with lower pCR probability in the overall cohort (OR 0.957, 95% CI 0.928–0.986; p = 0.004) and shorter DFS in TNBC (HR 1.023, 95% CI 1.001–1.047; p = 0.04).

Conclusion
On-treatment biopsies can predict patients unlikely to achieve pCR post-therapy. This could facilitate therapy adjustments for TNBC or HER2 + BC. They also might offer insights into therapy resistance mechanisms. Future research should explore whether standardized or expanded sampling enhances the accuracy of on-treatment biopsy procedures.
Trial registration GeparQuattro (EudraCT 2005-001546-17), GeparQuinto (EudraCT 2006-005834-19) and GeparSixto (EudraCT 2011-000553-23).
Phytochemical composition and green insecticides from Citrus aurantifolia fruit peels against whitefly, Bemisia tabaci
Authors: El-Alfy Mariam S. , Mostafa Mohamed E. , Dawidar Abelaziz M. , Abdel-Mogib Mamdouh 
Published: September 2024

AbstractInsecticidal potential of extracts of Citrus aurantifolia, family Rutaceae, was evaluated to control whiteflies, Bemisia tabaci. Biocidal activity directed chromatographic separation of chloroform and butanol fractions, with spectral identification (1D-NMR, 2D-NMR, ESIMS) of the active fractions have been resulted in separation and structural elucidation of for previously described coumarins (bergapten 1, limettin 2, isopimpinellin 3, oxypeucedanin hydrate 4) in addition to a new dimeric coumarin (12R, 12’R)-aurantifolin 5, two known limonoids; 21,23-dihydro-23-methoxy-21-oxolimonin 6, 21,23-dihydro-23-methoxy-21-oxonomilin 7, and two known flavonoid glycosides; scoparin 8, and narcissin 9. Amongst these compounds, narcissin 9 was the most effective after 24 h. of treatment while, (12R, 12’R)-aurantifolin 5 was the most potent against B. tabaci, 3rd instar nymphs after 72 h. of treatment and under laboratory conditions, with LC50 values of 33.31and 15.92 ppm, respectively comparing with the positive control azadirachtin.
Development Length Assessment of Bonded Post-Tensioning Slabs with Bulb-Shaped Dead end Anchorage
Authors: Aly Jehan H. , Maree A. Farghal , Kohail Mohamed , Khalil Ayman H. 
Published: September 2024

AbstractThe bond between prestressing strands and concrete within the dead-end zone of a post-tensioned concrete member significantly influences the effectiveness of the strand-concrete system. However, the existing code equations for determining development length rely on studies conducted on pretensioned concrete members rather than post-tensioned ones. As a result, the implementation of development length for prestressing strands with bulb-shaped dead end anchorage in post-tensioning slabs relies on common practice and former experience. Unfortunately, this can sometimes lead to concrete cracks or strand slippage at the dead end zone due to insufficient development length. This paper presents an experimental study on post-tensioning slab segments representing the dead end zone. The aim of this study is to assess the development length of prestressing strands with bulb-shaped dead end that shall guarantee full bond with concrete throughout the member’s service life. The Specimens were divided according to three different concrete compressive strengths 34 MPa, 48 MPa and 70 MPa. The parameters considered included slab thicknesses of 160 mm and 250 mm, as well as strand embedment lengths of 700 mm and 850 mm. Based on the test results, the sufficient development length was determined. Furthermore, a verification was carried out to assess the validity of applying predicted equations from an adopted bond model to determine the bond strength of strand with bulb-shaped dead end anchorage in concrete slabs.
Validating the ChatGPT Usage Scale: psychometric properties and factor structures among postgraduate students
Authors: Nemt-allah Mohamed , Khalifa Waleed , Badawy Mahmoud , Elbably Yasser , Ibrahim Ashraf 
Published: September 2024

Abstract
Background
The rapid adoption of ChatGPT in academic settings has raised concerns about its impact on learning, research, and academic integrity. This study aimed to develop and validate a comprehensive ChatGPT Usage Scale specifically tailored to postgraduate students, addressing the need for a psychometrically sound instrument to assess the multidimensional nature of ChatGPT usage in higher education.

Methods
A cross-sectional survey design was employed, involving 443 postgraduate students from two Egyptian universities. The initial 39-item scale underwent Exploratory Factor Analysis (EFA) using principal component analysis with Varimax rotation. Confirmatory Factor Analysis (CFA) was conducted to assess the model fit and psychometric properties of the final 15-item measure. Internal consistency reliability was evaluated using Cronbach’s alpha and McDonald’s omega.

Results
EFA revealed a three-factor structure explaining 49.186% of the total variance: Academic Writing Aid (20.438%), Academic Task Support (14.410%), and Reliance and Trust (14.338%). CFA confirmed the three-factor structure with acceptable fit indices (χ2(87) = 223.604, p < .001; CMIN/DF = 2.570; CFI = 0.917; TLI = 0.900; RMSEA = 0.060). All standardized factor loadings were statistically significant (p < .001), ranging from 0.434 to 0.728. The scale demonstrated good internal consistency (Cronbach’s α = 0.848, McDonald’s ω = 0.849) and composite reliability (CR = 0.855). The average variance extracted (AVE) was 0.664, supporting convergent validity.

Conclusions
The validated ChatGPT Usage Scale provides a reliable and valid instrument for assessing postgraduate students’ engagement with ChatGPT across multiple dimensions. This tool offers valuable insights into AI-assisted academic practices, enabling more nuanced investigations into the effects of ChatGPT on postgraduate education.
Culture, tradition and healthcare: exploring the Kisiizi Community Health Insurance scheme
Authors: Kakama Alex Ayebazibwe , Atuheire Ambrose , Kahyana Danson 
Published: September 2024

AbstractIn southwestern Uganda, a custom of health and social support has been managed through collective organizations known as engozi for centuries. Subscribers advanced help for those who were not able to provide for themselves and their households. Participants pooled financial and food resources, offered emotional assistance, and aided in transporting patients to hospitals. The institution of “free government health amenities” caused the decline of the engozi custom. However, with an insufficient annual health sector budget allocation, the state health services cannot satisfactorily meet the needs. The Kisiizi neighborhood, while depending on the engozi practice, arrived at a CHI system in 1996 as a self-help innovation to eliminate financial obstacles and enhance access to quality health amenities. Numerous studies on CHI have examined the structure, registration and memberships, health-related advantages, and monetary-related benefits, but little has been documented on how cultural beliefs and customs have affected its application. This study aimed to identify the role of culture and customs in tackling healthcare disparities via a CHI strategy. This study adopted a case study methodology and qualitative methods. The study utilizes Woolcock’s social capital theory and Cultural competence theory as the analytical framework. It identifies Brotherhood, Solidarity, Belonging, Cooperation, Volunteering, Reciprocity, and Respect for Authority and Leaders as key values upheld by the engozi tradition, strengthening social capital and laying a solid foundation for successful CHI. This study also identified that societal values and traditions have significantly impacted the implementation of the Kisiizi CHI scheme, as evidenced by the influence on CHI leadership and governance, collecting premium fees from subscribers, mobilization and registration of participants, and information dissemination. Lastly, the study identified that CHI has positively affected healthcare challenges within the community, evidenced by increased utilization of healthcare services, improved access to antenatal care, health promotion and disease prevention initiatives, and improved quality of services due to user feedback.
Nothophoma spp. causing leaf blight of ancient Platycladus orientalis
Authors: Jiao Ning , Wang Jiawen , Zhang Zhe , Zhang Ying 
Published: September 2024

AbstractAncient Platycladus orientalis holds significant ecological, landscape, historical, and cultural value. In northern China, leaf blight has significantly impacted the growth and ornamental value of ancient P. orientalis. In this study, 26 blight leaf samples of ancient P. orientalis were collected in Beijing, China. Phylogenetic analysis based on the concatenated internal transcribed spacer (ITS), β-tubulin (tub2), and RNA polymerase second largest subunit (rpb2) DNA sequence data combined with fungal morphological characteristics revealed three taxa of Nothophoma, i.e. N. platycladus, N. spiraeae, and N. juglandis. Of which, N. platycladus is a species new to science. Koch’s postulates indicated that all these three species of Nothophoma could cause leaf blight of P. orientalis.