bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of Human cDNA Library Reveals Two differentiation-Related Genes, HHEX and HLX, as Promoters of Early Phase Reprogramming toward Pluripotency
Authors: Yamakawa Tatsuya , Sato Yoshiko , Matsumura Yasuko , Kobayashi Yukiko , Kawamura Yoshifumi , Goshima Naoki , Yamanaka Shinya , Okita Keisuke 
Published: June 2016

Abstract
Gene screenings have identified a number of reprogramming factors that induce pluripotency from somatic cells. However, the screening methods have mostly considered only factors that maintain pluripotency in embryonic stem cells, ignoring a potentially long list of other contributing factors involved. To expand the search, we developed a new screening method that examined 2,008 human genes in the generation of human induced pluripotent stem cells (iPSCs), including not only pluripotent genes but also differentiation-related genes that suppress pluripotency. We found the top 100 genes that increased reprogramming efficiency and discovered they contained many differentiation-related genes and homeobox genes. We selected two, HHEX and HLX, for further analysis. These genes enhanced the appearance of premature reprograming cells in the early phase of human iPSC induction, but had inhibitory effect on the late phase. In addition, when expressed in human iPSCs, HHEX and HLX interfered with the pluripotent state, indicating inverse effects on somatic reprograming and pluripotent maintenance. These results demonstrate that our screening is useful for identifying differentiation-related genes in somatic reprograming.
Why we love ATC‐63: part ii, technology transfer
Authors: Hart Gary C. , Simsir Can C. 
Published: June 2016

SummaryThis paper represents a follow up (Part II) to the original paper published in 2008 in this journal. It presents the learning from the first paper and also the results of recent work by the authors to apply and illustrate to other structural engineers the many benefits of Applied Technology Council. . This includes the use of mathematical equations from structural reliability theory, incorporation of professional judgment of the structural engineer of record and maximum utilization of published peer reviewed laboratory and testing of building components and systems. Copyright © 2016 John Wiley & Sons, Ltd.
Robust secret key extraction from channel secondary random process
Authors: Badawy Ahmed , Elfouly Tarek , Khattab Tamer , Chiasserini Carla‐Fabiana , Mohamed Amr , Trinchero Daniele 
Published: June 2016

AbstractThe vast majority of existing secret key generation protocols exploit the inherent randomness of the wireless channel as a common source of randomness. However, independent noise added at the receivers of the legitimate nodes affects the reciprocity of the channel. In this paper, we propose a new simple technique to generate the secret key that mitigates the effect of noise. Specifically, we exploit the estimated channel to generate a secondary random process (SRP) that is common between the two legitimate nodes. We compare the estimated channel gain and phase to a preset threshold. The moving differences between the locations at which the estimated channel gain and phase exceed the threshold are the realization of our SRP. We study the properties of our generated SRP and derive a closed form expression for the probability mass function of the realizations of our SRP. We simulate an orthogonal frequency division multiplexing system and show that our proposed technique provides a drastic improvement in the key bit mismatch rate between the legitimate nodes when compared with the techniques that exploit the estimated channel gain or phase directly. In addition to that, the secret key generated through our technique is longer than that generated by conventional techniques. Moreover, we compute the conditional probabilities used to estimate the secret key capacity. Copyright © 2016 John Wiley & Sons, Ltd.
Blood vessel crosstalk during organogenesis—focus on pancreas and endothelial cells
Authors: Azizoglu D. Berfin , Cleaver Ondine 
Published: June 2016

Blood vessels form a highly branched, interconnected, and largely stereotyped network of tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their particular architecture, or how they are ‘patterned,’ and in turn, how they influence surrounding tissues are fundamental questions of organogenesis. Decades of work have begun to elucidate how endothelial progenitors arise and home to precise locations within tissues, integrating attractive and repulsive cues to build vessels where they are needed. Conversely, more recent findings have revealed an exciting facet of blood vessel interaction with tissues, where vascular cells provide signals to developing organs and progenitors therein. Here, we discuss the exchange of reciprocal signals between endothelial cells and neighboring tissues during embryogenesis, with a special focus on the developing pancreas. Understanding the mechanisms driving both sides of these interactions will be crucial to the development of therapies, from improving organ regeneration to efficient production of cell based therapies. Specifically, elucidating the interface of the vasculature with pancreatic lineages, including endocrine cells, will instruct approaches such as generation of replacement beta cells for Type I diabetes. WIREs Dev Biol 2016, 5:598–617. doi: 10.1002/wdev.240This article is categorized under:

Signaling Pathways > Cell Fate Signaling
Vertebrate Organogenesis > Musculoskeletal and Vascular
Adult Stem Cells, Tissue Renewal, and Regeneration > Tissue Stem Cells and Niches
Synthesis, Structures, and Photocatalytic Properties of Zinc(II) and Cobalt(II) Supramolecular Complexes Constructed with Flexible Bis(thiabendazole) and Dicarboxylate Linkers
Authors: Huan Dian‐Heng , Zhao Yan‐Qin , Hao Zeng‐Chuan , Cui Guang‐Hua 
Published: June 2016

AbstractThree coordination complexes, namely, [Zn(btbp)(3‐npa)]n (1), [Co(btbh)(3‐npa)]n (2), and {[Co(btbb)(5‐nipa)(H2O)]·H2O}n (3) (btbp = 1,3‐bis(thiabendazole)propane, btbh = 1,6‐bis(thiabendazole)hexane, btbb = 1,4‐bis(thiabendazole)butane, 3‐H2npa = 3‐nitrophthalic acid and 5‐H2nipa = 5‐nitroisophthalic acid) were synthesized under hydrothermal conditions and characterized by physicochemical and spectroscopic methods as well as by single‐crystal X‐ray diffraction. Complex 1 features a fascinating meso‐helical chain, which is further extended into a 2D supramolecular framework involving π···π stacking interactions. Complexes 2 and 3 show dinuclear structures. Complex 2 is further connected through C–H···O hydrogen bonding interactions to afford a 2D supramolecular layer, whereas complex 3 is further extended to a rare 2‐nodal (3,4)‐connected supramolecular sheet with a point symbol of {3.42.5.6.7}2{3.82} by O–H···O hydrogen bonding interactions. The electrochemical behaviors of the two cobalt complexes 2 and 3 were reported. Moreover, the luminescent properties for 1 and the photocatalytic properties for the complexes were investigated.
Kidney Transplant Outcomes in the Super Obese: A National Study From the UNOS Dataset
Authors: Kanthawar Pooja , Mei Xiaonan , Daily Michael F. , Chandarana Jyotin , Shah Malay , Berger Jonathan , Castellanos Ana Lia , Marti Francesc , Gedaly Roberto 
Published: June 2016

AbstractBackgroundWe evaluated outcomes of super‐obese patients (BMI > 50) undergoing kidney transplantation in the US.MethodsWe performed a review of 190 super‐obese patients undergoing kidney transplantation from 1988 through 2013 using the UNOS dataset.ResultsSuper‐obese patients had a mean age of 45.7 years (21–75 years) and 111 (58.4 %) were female. The mean BMI of the super‐obese group was 56 (range 50.0–74.2). A subgroup analysis demonstrated that patients with BMI > 50 had worse survival compared to any other BMI class. The 30‐day perioperative mortality and length of stay was 3.7 % and 10.09 days compared to 0.8 % and 7.34 days in nonsuper‐obese group. On multivariable analysis, BMI > 50 was an independent predictor of 30‐day mortality, with a 4.6‐fold increased risk of perioperative death. BMI > 50 increased the risk of delayed graft function and the length of stay by twofold. The multivariable analysis of survival showed a 78 % increased risk of death in this group. Overall patient survival for super‐obese transplant recipients at 1, 3, and 5 years was 88, 82, and 76 %, compared to 96, 91, 86 % on patients transplanted with BMI < 50. A propensity score adjusted analysis further demonstrates significant worse survival rates in super‐obese patients undergoing kidney transplantation.ConclusionSuper‐obese patients had prolonged LOS and worse DGF rates. Perioperative mortality was increased 4.6‐fold compared to patients with BMI < 50. In a subgroup analysis, super‐obese patients who underwent kidney transplantation had significantly worse graft and patient survival compared to underweight, normal weight, and obesity class I, II, and III (BMI 40–50) patients.
The International Association of Hydrogeologists (IAH): reflecting on 60 years of contributions to groundwater science and water management
Authors: Struckmeier Willi , Howard Ken , Chilton John 
Published: June 2016

Abstract
The 60th anniversary of the founding of the International Association of Hydrogeologists (IAH) is an important milestone that allows pause for reflection on how the association has evolved over the years and the contributions it has made to groundwater science and water management. IAH was founded in 1956 at the 20th International Geological Congress and developed rapidly during the 1980s and 1990s in response to a growing global interest in groundwater mapping and in sound approaches to resource protection and sustainable aquifer management. Incorporated in 2000, IAH has now secured its position as the world’s leading international association specialising in groundwater with over 4,100 members in 131 countries. Much credit for this success must go to members, past and present, whose individual efforts and collaboration with sister institutions are documented here. These members have shaped the association’s goals and contributed selflessly to its scientific programmes, publications and educational and charitable activities. Looking ahead to the next 60 years, it is essential that IAH does not rest on past achievements but listens and adjusts to the needs of members while continuing to pursue its mission of furthering the understanding, wise use and protection of groundwater resources throughout the world.
2013 Review and Update of the Genetic Counseling Practice Based Competencies by a Task Force of the Accreditation Council for Genetic Counseling
Authors: Doyle Debra Lochner , Awwad Rawan I. , Austin Jehannine C. , Baty Bonnie J. , Bergner Amanda L. , Brewster Stephanie J. , Erby Lori A. H. , Franklin Cathi Rubin , Greb Anne E. , Grubs Robin E. , Hooker Gillian W. , Noblin Sarah Jane , Ormond Kelly E. , Palmer Christina G. , Petty Elizabeth M. , Singletary Claire N. , Thomas Matthew J. , Toriello Helga , Walton Carol S. , Uhlmann Wendy R. 
Published: June 2016

AbstractThe first practice based competencies (PBCs) for the field of genetic counseling were adopted by the American Board of Genetic Counseling (ABGC), 1996. Since that time, there has been significant growth in established and new work settings (clinical and non‐clinical) and changes in service delivery models and the roles of genetic counselors. These changes prompted the ABGC to appoint a PBC Task Force in 2011 to review the PBCs with respect to their current relevance and to revise and update them as necessary. There are four domains in the revised PBCs: (I) Genetics Expertise and Analysis (II) Interpersonal, Psychosocial and Counseling Skills (III) Education and (IV) Professional Development and Practice. There are 22 competencies, each clarified with learning objectives or samples of activities and skills; a glossary is included. New competencies were added that address genomics, genetic testing and genetic counselors’ roles in risk assessment, education, supervision, conducting research and presenting research options to patients. With PBCs serving as the pre‐defined abilities or outcomes of training, graduating genetic counselors will be well prepared to enter the field with a minimum level of skills and abilities. A description of the Task Force's work, key changes and the 2013 PBCs are presented herein.
Identifying non-accidental fractures in children aged <2 years
Authors: Leaman Laura A. , Hennrikus William L. , Bresnahan James J. 
Published: June 2016

Purpose Fractures are the second most common presentation of child abuse following soft-tissue bruising and burns. It is often difficult to determine potential abuse in a child presenting with a non-rib fracture(s) and without soft-tissue injuries. Methods One hundred and fifteen consecutive patients aged ≤2 years who presented with a fracture between January 2010 and June 2012 to our emergency department (ED) or pediatric fracture clinic were retrospectively analyzed. Statistical analyses were carried out for non-accidental fractures based on age (<1 year vs 1–2 years), location of presentation (ED vs pediatric fracture clinic), type of long bone fracture, number of fractures, and patient demographics. Results Fractures in 19 of 115 (17 %) patients were reported as non-accidental trauma (NAT). Eighty (70 %) of the 115 patients first reported to the ED. Thirty-two percent of fractures in children aged <1 year and 5 % of fractures in children aged 1–2 years were reported as NAT ( p < 0.001). Sixteen of 19 (84 %) patients reported for abuse had multiple fractures; 15 of these patients were aged <1 year. Eight of 11 (73 %) reported femoral fractures were transverse fractures. Corner fractures (12) only occurred in children aged <1 year and never occurred in isolation; all of them were reported as NAT. Four of 60 patients (7 %) with commercial insurance and 15 of 55 patients (28 %) with Medicaid were reported as NAT. Conclusions Age less than 1 year, multiple fractures, corner fractures, transverse fractures, and covered by Medicaid were the most common factors associated with reporting of NAT.
Characterization of miniature fiber-optic Fabry-Perot interferometric sensors based on hollow silica tube
Authors: Jia Pinggang , Fang Guocheng , Wang Daihua 
Published: June 2016

Abstract
A miniature fiber-optic Fabry-Perot interferometer (MOFPI) fabricated by splicing a hollow silica tube (HST) with inner diameter of 4 µm to the end of a single-mode fiber is investigated and experimentally demonstrated. The theoretical relationship between the free spectrum range and the length of HST is verified by fabricating several MOFPIs with different lengths. We characterize the MOFPIs for temperature, liquid refractive index, and strain. Experimental results show that the sensitivities of the temperature, liquid refractive index, and strain are 16.42 pm/°C,–118.56 dB/RIU, and 1.21 pm/µε, respectively.
Colorectal cancer: comparative analysis of clinical and pathological characteristics in patients aged above and below 45 years of age and impact on prognosis
Authors: Pestana Joana Sofia Gomes , Martins Sandra Fátima Fernandes 
Published: June 2016

Abstract
Introduction Colorectal cancer, in Portugal, presents as the second most common cancer and of cancer death cause. CRC is a disease of the elderly; however, there has been an increase of incidence in younger patients and doubts have emerged about its behavior, characteristics and prognosis in this group.
Methods In this study, we have evaluated a sample of 512 patients diagnosed with colorectal cancer submitted to surgical treatment in the period between January 1st, 2005 and January 1st, 2010, through a comparative clinical, pathological and survival analysis of patients under and over 45 years old (Groups I and II respectively).
Results Group I patients accounted for 5.5% of the sample. There was a predominance of males and the most common site was the left colon in both age groups. In the younger group, the histological type presents with a predominance of tumors with a mucinous component and with signet ring cells (p = 0.001), however, there was no difference in terms of overall survival and disease-free survival.
Conclusion In this study, colorectal cancer at younger ages shows similar characteristics to those of older patients.
Groove-induced changes of discharge in channel flows
Authors: Chen Yu , Floryan J. M. , Chew Y. T. , Khoo B. C. 
Published: June 2016

The changes in discharge in pressure-driven flows through channels with longitudinal grooves have been investigated in the laminar flow regime and in the turbulent flow regime with moderate Reynolds numbers ($Re_{2H}\approx 6000$) using both analytical and numerical methodologies. The results demonstrate that the long-wavelength grooves can increase discharge by 20 %–150 %, depending on the groove amplitude and the type of flow, while the short-wavelength grooves reduce the discharge. It has been shown that the reduced geometry model applies to the analysis of turbulent flows and the performance of grooves of arbitrary form is well approximated by the performance of grooves whose shape is represented by the dominant Fourier mode. The flow patterns, the turbulent kinetic energy as well as the Reynolds stresses were examined to identify the mechanisms leading to an increase in discharge. It is shown that the increase in discharge results from the rearrangement of the bulk fluid movement and not from the suppression of turbulence intensity. The turbulent kinetic energy and the Reynolds stresses are rearranged while their volume-averaged intensities remain the same as in the smooth channel. Analysis of the interaction of the groove patterns on both walls demonstrates that the converging–diverging configuration results in the greatest increase in discharge while the wavy channel configuration results in a reduction in discharge.
Compositional inhomogeneities as a source of indirect combustion noise
Authors: Magri Luca , O’Brien Jeff , Ihme Matthias 
Published: June 2016

The generation of indirect combustion noise by compositional inhomogeneities is examined theoretically. For this, the compact-nozzle theory of Marble & Candel (J. Sound Vib., vol. 55 (2), 1977, pp. 225–243) is extended to a multi-component gas mixture, and the chemical potential function is introduced as an additional acoustic source mechanism. Transfer functions for subcritical and supercritical nozzle flows are derived, and the contribution of compositional noise is compared to entropy noise and direct noise by considering an idealized nozzle downstream of the combustor exit. It is shown that compositional noise is dependent on the local mixture composition and can exceed entropy noise for fuel-lean conditions and supercritical nozzle flows. This suggests that the compositional indirect noise requires potential consideration with the implementation of low-emission combustors.
Propagation of Love-Type Wave in a Corrugated Fibre-Reinforced Layer
Authors: Singh A. K. , Mistri K. C. , Das A. 
Published: June 2016

AbstractThe present paper investigates the propagation of Love-type waves in an initially stressed heterogeneous fibre-reinforced layer with corrugated boundary surfaces, lying over a viscoelastic half-space under hydrostatic state of stress. The dispersion relation is obtained in closed form and found to be in well-agreement with the classical Love wave equation. The substantial effect of reinforcement, position and undulation parameters (i.e.corrugation), heterogeneity, horizontal initial stress and hydrostatic state of stress are discussed briefly. It is established through comparative study that reinforced layer supports more to phase velocity of Love-type wave as compare to reinforced free layer.
Taxonomy and biogeography of the Pleistocene New Zealand sea lionNeophoca palatina(Carnivora: Otariidae)
Authors: Churchill Morgan , Boessenecker Robert W. 
Published: June 2016

AbstractThe Otariidae (fur seals and sea lions) are an important and highly visible component of Southern Hemisphere marine mammal faunas. However, fossil material of Southern Hemisphere otariids is comparatively rare and often fragmentary. One exception is the Pleistocene sea lionNeophoca palatinaKing, 1983a, which is known from a nearly complete skull from the North Island of New Zealand. However, the phylogenetic affinities of this taxon are poorly known, and comparisons with other taxa have been limited. We provide an extensive redescription ofNeophoca palatinaand diagnose this taxon using a morphometric approach. Twenty measurements of the skull were collected forN. palatina, as well as for all extant Australasian otariids and several fossilNeophoca cinereaPerón, 1816. Using principal component analysis, we were able to segregate taxa by genus, andN. palatinawas found to cluster withNeophocaaccording to overall size of the skull as well as increased width of the intertemporal constriction and interorbital region.N. palatinacan be distinguished from all other Australasian otariids by its unusually broad basisphenoid. Discriminant function analysis supported referral ofNeophoca palatinatoNeophocawith very high posterior probability. These results confirm the treatment ofNeophoca palatinaas a distinct species ofNeophocaand highlight the former broad distribution and greater tolerance for colder temperatures of this genus. These results also suggest that New Zealand may have played a pivotal role in the diversification of Southern Hemisphere otariid seals.
Redescriptions of some Lower Devonian gastropods from Tennessee currently considered to be platyceratids
Authors: Harper John A. 
Published: June 2016

AbstractThree genera of gastropods described from the Lower Devonian Rockhouse Formation of Hardin County, Tennessee, currently are considered to be junior subjective synonyms ofPlatyceras(Visitator) Perner, 1911. Evaluation of the type specimens of these genera as well as types of two other gastropods from the same formation reveals the following:Platyostoma quadrangulare(Dunbar, 1920) is the only platyceratid gastropod among them;Saffordella tennessensisDunbar, 1920 has a selenizone above midwhorl so it is an eotomarioidean belonging to the Gosseletinidae;Aulopea nelsoniDunbar, 1920 and the lectotype ofDistemnostoma princepsDunbar, 1920 each has a broad subsutural sinus on the upper whorl surface similar to the Omphalotrochidae, as well as a basal sinus similar to certain primitive caenogastropods, so their systematic position is uncertain; I considerHolopea planidorsataDunbar, 1920 to be a juvenile specimen ofD. princeps; the fragmentary paralectotype ofD. princepspossibly represents a gerontic form ofDistemnostoma curtumDunbar, 1920, which possesses a well-developed selenizone on an upwardly projecting shoulder at the edge of the upper whorl surface. BecauseD. curtumappears to be unrelated toD. princeps, the genotype ofDistemnostoma, I propose the new generic nameOmocordellaforD. curtum. The new family Micromphalidae is erected to include OrdovicianSlehoferiaRohr and Fryda, 2001, lower CarboniferousMicromphalusKnight, 1945, andOmocordellan. gen.