bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assistência de enfermagem na prevenção da síndrome de HELLP em gestantes
Authors: Reis Luciana Paiva , Santos Talita Victória Charles Carneiro Dos , Santos Cidiana Silva Marques , Pereira Jabneela Vieira 
Published: September 2024

Objetivo: Investigar por meio de revisão integrativa quais são as principais assistências de enfermagem que podem ser empregadas para o diagnóstico precoce e prevenção da Síndrome de HELLP em gestantes. Métodos: Trata-se de uma revisão integrativa com corte temporal de 2012 a 2022, em buscas nas bases de dados como PubMed e mecanismo de busca Google Acadêmico e Biblioteca Virtual da Saúde referente a síndrome de HELLP e assistência de enfermagem. Resultados: A maioria dos estudos evidenciaram que a síndrome de HELLP é uma complicação da pré-eclâmpsia, que quando instalada, pode gerar risco tanto para a gestante quanto para o feto. Quanto ao papel do enfermeiro, destaca-se que o pré-natal é o principal instrumento de rastreio, acompanhamento e de intervenção em casos de agravamento da pré-eclâmpsia. A monitorização e a mudança de estilo de vida constituem a principal forma de prevenção contra a síndrome de HELLP. Considerações finais: A síndrome HELLP é uma condição obstétrica potencialmente fatal que requer diagnóstico e intervenção precoce. A assistência de enfermagem é essencial para garantir a saúde e a segurança da mãe e do bebê, envolvendo cuidados preventivos, identificação precoce de sintomas e intervenção em casos graves.
Under the rays of the «K.E. Tsiolkovsky Stars» – from a dream to the practical implementation (to the 35th anniversary of the Kaluga Branch of Lavochkin Association, JSC)
Authors: Середин П.В. , Артемьев А.В. , Моишеев А.А. , Рыков Е.В. , Штокал А.О. 
Published: September 2024

Отмечена преемственность научно-производственной деятельности Филиала АО «НПО Лавочкина» в г. Калуга (далее – Филиал) идеям и проектам К.Э. Циолковского. Приведены сведения об этапах становления и развития Филиала. Выделены задачи и направления развития на каждом этапе функционирования Филиала. Указан вклад каждого руководителя Филиала в решение приведённых задач и реализацию общих проектов. Изложено структурное деление Филиала, сформированное на основе выполняемых его подразделениями работ. Обозначены перспективные направления развития структур Филиала с учётом особенностей региона
The continuity of the scientific and production activities of the Kaluga Branch of Lavochkin Association, JSC (hereinafter referred to as the Branch) to the ideas and projects of K.E. Tsiolkovsky is noted. Information about the stages of formation and development of the Branch is provided. The tasks and directions of development at each stage of the Branch's operation are highlighted. The contribution of each Branch manager to the solution of the given tasks and the implementation of common projects is indicated. The structural division of the Branch, formed on the basis of the work performed by its divisions, is outlined. Promising directions of the development of the Branch's structures considering the characteristics of the region are outlined
Gambaran Kesiapsiagaan Bencana Pada Mahasiswa/i Fakultas Kedokteran Universitas Malikussaleh
Authors: Nasution Decy Erni , Napitupulu Muhammad , Z Khairunnisa , Sofia Rizka 
Published: September 2024

Negara Republik Indonesia yang berada di lingkaran cincin api Pasific (ring of fire) merupakan negara yang rawan bencana. Pada tahun 2022 tercatat 3.544 kejadian bencana alam di Indonesia yang mengakibatkan 6.144.324 jiwa menderita dan mengungsi, 861 jiwa meninggal dunia, 46 jiwa hilang dan 8.727 jiwa mengalami luka-luka, juga mengakibatkan kerusakan infrastruktur dimana 95.403 unit rumah rusak, 1.983 unit fasilitas umum rusak, 163 unit kantor rusak, dan 342 unit jembatan rusak. Keadaan ini mengakibatkan seluruh komponen pemerintahan maupun masyarakat harus selalu siaga menghadapi bencana. Fakultas Kedokteran Universitas Malikussaleh yang mempunyai visi dan misi untuk menjadi yang terdepan dalam masalah kebencanaan baik secara nasional maupun internasional telah membekali mahasiswa/inya agar siap menghadapi bencana dengan memasukkan mata pelajaran kebencanaan di dalam kurikulum yang diajarkan secara teori maupun praktek. Penelitian ini bertujuan melihat gambaran kesiapsiagaan mahasiswa/i Fakultas kedokteran Universitas Malikussaleh tahun angkatan 2019 s/d 2022 terhadap bencana. Penelitian bersifat deskriptif dengan metode cross sectional, menggunakan seluruh total populasi sebanyak 379 orang mahasiswa sebagai sampel (total sampling). Pengukuran tingkat kesiapsiagaan menggunakan kuesioner berstandar LIPI-UNESCO/ISDR yang telah tervalidasi, dengan 5 parameter, yaitu Pengetahuan, Sikap, Rencana Tanggap darurat, Sistem Peringatan Dini dan Mobilisasi Sumber Daya. Pengolahan data dilakukan secara univariat. Hasil penelitian menunjukkan bahwa dari total responden, mayoritas berjenis kelamin wanita (74,67%) dibandingkan pria (25,33%), dengan total populasi tertinggi terdapat pada tahun angkatan 2022 (100 orang), terendah tahun angkatan 2020 (90 orang). Nilai rata-rata total kesiapsiagaan mahasiswa/i Fakultas Kedokteran Universitas Malikussaleh dalam menghadapi bencana tertinggi diperoleh mahasiswa/i tahun angkatan 2019 (88,98%), terendah tahun angkatan 2020 (81,54%). Mahasiswa pria memperoleh nilai rata-rata total 91,94%, lebih tinggi dibandingkan nilai rata-rata total mahasiswi wanita 86,02%. Secara keseluruhan nilai rata-rata total kesiapsiagaan menghadapi bencana yang diperoleh mahasiswa/i Fakultas Kedokteran Universitas Malikussaleh tahun angkatan 2019-2022 sudah tinggi (84,96%). Semoga nilai tersebut dapat dipertahankan dan lebih ditingkatkan lagi ke depannya. Kata kunci: Bencana, mahasiswa Fakultas Kedokteran Universitas Malikussaleh, Kesiapsiagaan bencana
Hubungan Pengetahuan dan Sikap Masyarakat Terhadap Pencegahan Penyakit Ispa Pasca Bencana Banjir di Desa Kumbang Kecamatan Lhoksukon
Authors: Inayati Rahmi , Nabila Dira Putri , Utariningsih Wheny , Herlina Nina 
Published: September 2024

ISPA merupakan penyakit yang berbahaya dan cenderung dapat mengakibatkan epidemi serta pandemi, sebab penyebaran dari penyakit ini sendiri dapat dengan mudah menular melalui droplet atau cairan yang dihasilkan dari batuk serta bersin. ISPA muncul akibat dari udara yang sangat dingin yang memicu aktifnya koloni kuman di dalam tubuh sehingga menimbulkan terjadinya infeksi saluran pernapasan. Penelitian ini bertujuan untuk menganalisis pengaruh pengetahuan dan sikap masyarakat terhadap pencegahan penyakit ISPA pasca bencana banjir di Desa Kumbang Kecamatan Lhoksukon. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional dengan responden sebanyak 115 responden. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah cluster sampling. Hasil didapatkan bahwa untuk distribusi usia paling banyak yaitu golongan lansia sebanyak 61 responden (53,0%), ditribusi jenis kelamin paling banyak yaitu berjenis kelamin perempuan dengan jumlah 64 responden (55,7%), distribusi pendidikan paling banyak yaitu golongan SMA/Sederajat dengan jumlah 37 responden (32,2%), distribusi pekerjan paling banyak yaitu golongan tidak bekerja/IRT berjumlah 31 responden (27,0%). Hasil penelitian menunjukkan bahwa mayoritas pengetahuan masyarakat menunjukkan dalam kategori baik (78,3%) dan sikap masyarakat menunjukkan dalam kategori positif (97,4%). Hasil analisis statistik menunjukan p value < 0,05, kesimpulan dari penelitian ini ada hubungan antara pengetahuan masyarakat terhadap pencegahan penyakit ISPA pasca bencana banjir di Desa Kumbang Kecamatan Lhoksukon dan juga adanya hubungan antara sikap dan pencegahan penyakit ISPA pasca bencana banir di Desa Kumbang Kecamatan Lhoksukon.
The Role of Video Thoracoscopy in the Diagnosis of Sarcoidosis
Authors: Opanasenko M.S. , Shalahai S.M. , Tereshkovych O.V. , Konik B.M. , Levanda L.I. , Liskina I.V. , Zahaba L.M. 
Published: September 2024

Sarcoidosis is a systemic autoimmune disease associated with the development of non-caseous granulomas. Early and accurate diagnosis of sarcoidosis is an important and difficult task, since the initial manifestations are diverse, nonspecific, and many patients are asymptomatic.
Objective — to study the role of video thoracoscopy and to present our own experience of invasive diagnosis of sarcoidosis.
Materials and methods. Patients included in the study were divided into 2 clinical groups depending on whether the diagnosis at admission coincided with the final diagnosis established after the morphological examination of lung biopsies or not. Group I — 74 patients with PDS and ML (41.6 %), whose diagnosis at admission coincided with the final clinical diagnosis (established on the basis of morphological examination of lung biopsies). Group II — 104 patients with PDS and ML (58.4 %), whose diagnosis upon admission did not coincide with the final clinical diagnosis.
Results and discussion. Insufficient diagnosis of lung cancer (lung carcinomatosis) — 3 (2.9 %) cases at admission and 31 (29.8 %) cases after lung biopsy. The small percentage of diagnosis of interstitial, granulomatous lesions of the lungs or pneumonitis with systemic connective tissue pathology is also noteworthy - 3 (2.9 %) cases before lung biopsy and 19 (18.3 %) after. In patients who were diagnosed with pulmonary sarcoidosis without histological confirmation, such a pathology as tuberculosis was found in 14 (13.5 %), oncological lesion — 23 (22.1 %), interstitial or granulomatous lesion together with pneumonia in systemic pathology — 17 (16.3 %) and «other» — 20 (19.2 %) cases. We performed 178 VATS biopsies, among which lung biopsy prevailed — 67 (37.6 %) cases, pleural biopsy was the least performed — 18 (10.1 %) cases. Intraoperative complications were recorded in 2 (1.1 %) cases, in the form of bleeding from a lymph node, the elimination of which required the use of electrocoagulation, the use of local and systemic hemostatic agents. Postoperative complications were observed in 5 (2.8 %) cases and were caused by the lack of lung tightness and the resulting long-term discharge of air through the drainage.
Conclusions. Manifestations of sarcoidosis often simulate other disseminated processes, so its invasive diagnosis is an effective and safe way of establishing the diagnosis, especially in complex cases and atypical clinical and radiological picture. Among invasive methods, preference should be given to mini-invasive methods, therefore, the optimal choice is VATS, which has high informativeness and a low percentage of postoperative complications and allows to evaluate a wide range of tissues such as the pleura, lymph nodes and lungs.
Oral Microbiocenosis in Cases of Inflammatory Periodontal Diseases in Children with Tuberculosis
Authors: Shylo M.M. 
Published: September 2024

Objective — to examine the microbial spectrum of the oral cavity in cases of inflammatory periodontal diseases of children with tuberculosis.
Materials and methods. A study of the microbial habitat of oral biotopes and gingival surfaces was conducted in 97 children aged 6 to 17 years with inflammatory periodontal diseases and tuberculosis (treatment group). The control group consisted of 20 practically healthy children of the same age. The periodontal diseases were diagnosed according to M.F. Danilevsky’s classification (2000). The study of oral microbiocenosis and gingival surfaces in the examined groups of children was performed in accordance with Order No. 234 of the Ministry of Health of Ukraine as of 2006.
Results and discussion. Aerobic, facultative anaerobic, and anaerobic bacteria persisted in the oral fluid and on the gingival surfaces of children with tuberculosis and inflammatory periodontal diseases. The most frequent colonies of bacteria were Streptococcus, in particular S. mutans, S. salivarius, S. β-haemolyticus, Staphylococcus (S. aureus, S. epidermidis).The significant evidence of Neisseria (N. catarrhalis) and Corynebacterium (C. xerosis) was revealed in the oral cavity and gingival surfaces of the examined children. The microflora of children from the treatment group revealed mostly Lactobacillus genus. The microbial associations of the examined children consisted of Candida, E. coli fungi. Smear microscopy revealed viruses. S. aureus was higher in the children from the treatment group as compared to the healthy children. In addition, the concentration of microorganisms was higher on the gingival surface versus the oral fluid and was more evident in the children from the treatment group.
Conclusions. The obtained spectrum of the oral microbial contamination in the children with tuberculosis and inflammatory periodontal diseases revealed the persisting associations of aerobic, facultative anaerobic, and anaerobic bacteria. The inflammatory periodontal diseases in tuberculosis-infected children were accompanied by the evident increase in the frequency and concentration of microorganisms increasing with the higher severity of the specific process.
Impact of Comorbid Pathology and Severity of Clinical Course on Anti-infective Protection in Patients with COVID-19
Authors: Sokolenko M.O. 
Published: September 2024

Objective — to establish and evaluate the impact of comorbid pathology and the severity of the clinical course on the activity of anti-infective protection in patients with coronavirus disease 2019 (COVID-19), based on the analysis of the absolute and relative counts of major immune cell populations in peripheral blood.
Materials and methods. A cross-sectional prospective study was conducted involving 204 patients with COVID-19-associated pneumonia of mild, moderate and severe stages. The cohort included 106 (51.97 %) women and 98 (48.03 %) men, with an average age of (55.93 ± 8.75) years. Anti-infective ­protection was studied using comprehensive clinical blood analysis, including the count of major immune-competent cells. Patients were categorised into groups based on comorbi­dity, taking into account the predominant concurrent pathology at the time of examination (endocrine, cardiovascular or other).
Results and discussion. More severe COVID-19 cases were characterised by leukopenia, relative and absolute granulocytopenia, neutropenia, a slight hyporegenerative nuclear shift to the right and a reduction in the number of segmented neutrophils by 24.63—34.72 % (p ≤ 0.047—0.009) and eosinophilic granulocytes by 52.94—70.59 % (p ≤ 0.004—0.001). This was accompanied by relative and absolute agranulocytosis due to lymphocytosis (by 20.10—63.33 %; p ≤ 0.05—0.003) and monocytosis (by 40.0—74.12 %; p ≤ 0.046—0.049), indicating an active inflammatory infectious process of viral etiology against a background of decreased resistance and increased activity of the lymphocyte-macrophage link with the beginning of the formation of specific immune protection (cellular and humoral response to coronavirus intervention). Mild cases of COVID-19 showed a higher absolute count of peripheral blood granulocytes (by 48.25 %; p = 0.018), neutrophils, particularly segmented neutrophils and eosinophilic granulocytes, compared to moderate and severe cases (by 32.36—53.18 % (p ≤ 0.049—0.01) and 3.4 times (p ≤ 0.005—0.002)) and the lowest content of monocytes (by 35.41—42.57 %; p ≤ 0.049—0.046). In cases with concurrent endocrine and cardiological pathologies against a background of a more severe clinical course of COVID-19, immunoinflammatory changes intensified due to absolute and relative leukopenia, neutrophilic granulocytopenia, neutropenia, with the presence of relative lymphocytosis and monocytosis, and normal ESR indicators, confirming the inflammatory process of viral etiology, which, in the absence of treatment, may tend to form post-COVID and/or long-term effects of COVID-19 with multisystem involvement.
Conclusions. The study found an enhancement of the immunoinflammatory response and an increase in the depletion of cellular factors of non-specific anti-infective protection with the progression of the clinical manifestations of COVID-19, particularly against the backdrop of comorbid endocrine and/or cardiological pathology.
The Level of Vitamin D in Patients with Susceptible Pulmonary Tuberculosis and Evaluation of its Influence on the Clinical Course of the Disease
Authors: Todoriko L.D. , Toderika Ya.I. , Yeremenchuk I.V. , Slyvka V.I. 
Published: September 2024

Vitamin D insufficiency or deficiency is defined as a very common condition in the general population. On the one hand, vitamin D deficiency is associated with several adverse health conditions, on the other hand, vitamin D supplements are inexpensive and safe to use, which makes it an attractive therapeutic option for both doctors and patients, especially for groups risk among the population. Several researchers claim that vitamin D metabolites play an important role in the coordinated work of the body’s immune system by inducing the migration of phagocytes, modulating the Th1—Th2 cell balance, and differentiating T-regulatory cells.
Objective — to determine the level of vitamin D in patients with susceptible pulmonary tuberculosis and to evaluate its influence on the clinical course of the disease.
Materials and methods. The randomized case-control study included 45 patients with newly diagnosed pulmonary tuberculosis of the lungs with preserved sensitivity and 30 practically healthy individuals (PHI) of the control group. The level of vitamin D in blood serum was examined using the VD (Vitamin D) ELISA Kit (Optics Valley Biomedical Industrial Park, Wuhan, China (430075)), for the quantitative detection of vitamin D in blood serum, number: EU2541, parameter: 1.563—100 ng/ml.
Results and discussion. According to the results of our study, it was established that the average level of 25(OH)D concentration in the blood serum of patients with pulmonary tuberculosis was (18.46 ± 4.23) ng/ml, in the control group it was (28.834 ± 5.79) ng/ml and was statistically significant (p = 0.001). Our multivariate studies with binary logistic regression showed a strong direct relationship between the presence of a specific tubercular process and vitamin D deficiency (< 20 ng/ml) (OR 2.817, 95 % CI 1.287—4.894, p < 0.005.
Conclusions. Vitamin D deficiency was noted in 94 % of patients with pulmonary tuberculosis with severe intoxication syndrome (7—10 points). In tuberculosis with moderate intoxication syndrome (4—6 points), 69.7 % of patients had a vitamin D deficiency, which practically did not differ from indicators in patients with mild intoxication syndrome (1—3 points) — 67.2 % of people.
Efficiency of Treatment of Tuberculosis Patients: Realities, Problems and Perspectives (Review)
Authors: Pikas O.B. , Semeniuk M.A. 
Published: September 2024

An analysis of data from global experience and professional publications on modern treatment of tuberculosis patients and its effectiveness was carried out.The analysis of literary sources of recent years indicates an urgent problem regarding tuberculosis in Ukraine (especially in the conditions of martial law and the conduct of active hostilities). With early diagnosis and timely treatment, the number of patients decreases by 8 %.The effectiveness of the treatment of patients with pulmonary tuberculosis and the influence of various factors on it were evaluated. The effectiveness of treatment of newly diagnosed pulmonary tuberculosis in Ukraine does not exceed 70 %.An increase in the level of resistance of tuberculosis mycobacteria to anti-tuberculosis drugs was noted, and its treatment efficiency was not high. The effectiveness of treatment of such patients in Ukraine does not exceed 40—45 %. The inclusion of second-line drugs in the treatment regimen of patients with iso­niazid-­resistant tuberculosis increases the effectiveness of treatment by 11.8 %. The overall effectiveness of treatment of patients with multidrug-resistant tuberculosis (MDR-TB) in the world is 52 %, and only 10 % of patients are cured. The treatment of MRTB is three times longer (20 months) than that of the sensitive form and is significantly more expensive. Antimycobacterial drugs (AMBs) were used according to an individual regimen (18—20 months), then new AMBs were used (6 months), later versions of modified standardized short-term regimens (9 months). The BPaL regimen (bedaquiline, linezolid, pretomanide) was implemented for patients with multiple and extensively drug-resistant tuberculosis for 6 months (26 weeks or 182 doses), resulting in a cure rate of 90 % [35].The methods of optimizing the management of patients with pulmonary tuberculosis (including correction of treatment) in the conditions of martial law, which can be achieved by improving antimycobacterial and pathogenetic therapy, revealing new mechanisms and deepening the known regularities of the course of the disease, are evaluated.
Contribución de diferentes vías de señalización en el proceso de senescencia celular durante el desarrollo tumoral hipofisario experimental
Authors: Luque JN , Grondona E , Carreño L , Gutierrez S , Petiti J , Torres A , Mongi Bragato B , De Paul AL 
Published: September 2024

Evidencias de nuestro grupo demostraron el surgimiento del proceso de senescencia como un mecanismo que controla el crecimiento tumoral hipofisario. También se sabe que la supresión de las vías PI3K/Akt y ERK1/2 promueven la senescencia. De manera opuesta, la activación de la señalización de JNK, p38 y el factor nuclear kappa B (NF?B) median eventos moleculares clave que disparan dicho proceso. Se sabe que estos eventos regulan al factor de transcripción FOXO3. Basados en estas evidencias, evaluamos la contribución de dichas vías de señalización durante el desarrollo tumoral pituitario experimental.Para inducir el desarrollo tumoral pituitario, ratas Wistar macho adultas fueron implantadas subcutáneamente con cápsulas de silástico conteniendo benzoato de estradiol (30 mg) durante 10, 20, 40 y 60 días (E10-60; n=5). El grupo control se implantó con cápsulas vacía (n=5). Posteriormente, se evaluó por Western Blot y/o inmunohistoquímica los niveles total y fosforilados (p) de ERK1/2, Akt, JNK, p38, NF?B y FOXO3 en las diferentes etapas del desarrollo tumoral. El análisis estadístico se realizó con un test ANOVA-Fischer (p <0,05).Se detectó un incremento inicial, seguido por una supresión de pERK. Concomitantemente se evidenció una inhibición de pAkt durante el transcurso del desarrollo tumoral. A su vez, se evidenció un incremento progresivo en la expresión de pJNK y p38 a partir de E20. Los niveles de NF?B se observaron incrementados a nivel nuclear en E20 y E40. Por el contrario, se observó una supresión de FOXO3 nuclear a lo largo del desarrollo tumoral para luego retornar a niveles basales en E60.Estas evidencias demuestran por primera vez la existencia de señales independientes de Akt/JNK que regulan la actividad de FOXO3 en el contexto de un tumor hipofisario. Dentro de este complejo contexto glandular, existe una intrincada red de señalización que suprime las señales mitogénicas y dispara los eventos moleculares que promueven el proceso de senescencia a fin de regular el crecimiento tumoral hipofisario.