bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a GeoGebra-Assisted Web-Based Learning Module for Analytical Geometry in a STEM Context
Authors: Hidayat Dayat , Palupi Evangelista L W , Susanah Susanah , Setianingsih Rini , Sancoko Candra 
Published: September 2024

<p>In modern education, incorporating technology is crucial for enhancing learning experiences and ensuring equal access to education. By integrating technology, educators can create interactive and immersive learning environments that boost student engagement and motivation. This research aims to describe the development process and results of a GeoGebra-assisted, web-based module for analytical geometry within a STEM context. The research follows the ADDIE model, which includes five stages: analysis, design, development, implementation, and evaluation. Data collection methods include questionnaires, documentation, and literature reviews. Feasibility validation assesses the module's face and content validity, focusing on content, language, and appearance. Data analysis utilizes a Likert scale to assess the validity of the module's aspect categories. The results indicate that the web-based module was developed in accordance with each stage of the ADDIE model. Expert feasibility tests show that the module demonstrates good validity in terms of content, language, and appearance.</p><p> </p><p>Dalam pendidikan modern, mengintegrasikan teknologi sangat penting untuk meningkatkan pengalaman belajar dan memastikan akses pendidikan yang merata. Dengan mengintegrasikan teknologi, pendidik dapat menciptakan lingkungan belajar yang interaktif dan imersif yang meningkatkan keterlibatan dan motivasi siswa. Penelitian ini bertujuan untuk mendeskripsikan proses dan hasil pengembangan modul berbasis website berbantuan geogebra untuk geometri analitik pada konteks STEM. Penelitian ini merupakan penelitian pengembangan menggunakan model ADDIE yang terdiri dari 5 tahap yaitu analisis, desain, development, implementation, dan evaluation. Teknik pengumpulan data menggunakan angket, dokumentasi, literatur review. Validasi kelayakan dilakukan untuk mengetahui validitas muka dan isi pada modul berbasis website ini yang meliputi validitas konten, bahasa, dan tampilan. Analisis data menggunakan skala likert untuk mengetahui kelayakan aspek kategori. Hasil penelitian menunjukkan bahwa modul berbasis website telah dihasilkan berdasarkan tahapan setiap proses model pengembangan ADDIE dan berdasarkan uji kelayakan oleh para ahli, validitas dari modul berbasis website ini adalah baik dalam hal konten, bahasa, dan penampilan. </p>
WITHDRAWN: The Double Glycoprotein Rabies Virus Strain Shows Increased Propagation Rate and Boosted Immunogenicity.
Authors: Alamdary Ashkan , Gholami Alireza , Azizi Mohammad , Noormohammadi Zahra 
Published: September 2024

Abstract

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Revealing the Molecular Interplay of Coverage, Wettability, and Capacitive Response at the Pt(111)-Water Solution Interface under Bias
Authors: Cucinotta Clotilde S. , Raffone Federico , Khatib Rémi , Sulpizi Marialore 
Published: September 2024

Abstract

While electrified interfaces are crucial for electrocatalysis and corrosion, their molecular morphology remains largely unknown. Through highly realistic ab-initio molecular dynamics simulations of the Pt(111)-water solution interface in reducing conditions, we reveal a deep interconnection among electrode coverage, wettability, capacitive response, and catalytic activity. We identify computationally for the first time the experimentally hypothesised states for adsorbed hydrogen on Pt, HUPD and HUPD, revealing their role in governing interfacial water reorientation and hydrogen evolution. The transition between these two H coverage regimes with increasing potential, induces a shift from a hydrophobic to a hydrophilic interface and correlates with a change in the primary electrode screening mechanism. This results in a slope change in differential capacitance, marking the onset of the experimentally observed peak around the potential of zero charge. Our work produces crucial insights for advancing electrocatalytic energy conversion, developing deep understanding of electrified interfaces.
Centralized Traffic Signal Control for Massive-Scale Heterogeneous Trafﬁc Network via Deep Reinforcement Learning
Authors: Qiao SiYao , Wu Jia , Yi Chenglin , Ren YanYu 
Published: September 2024

Abstract

In order to alleviate the traffic congestion problems caused by urbanization and the increment in vehicles, researchers have proposed various methods for traffic signal optimization based on reinforcement learning. However, most of these methods focus on small-scale and homogeneous road networks. To address complex road network problems, we introduce a new method called Gen-CenLight, which utilizes a centralized control approach based on the Actor-Critic architecture. To achieve scalability and coordination in massive-scale networks, we have designed a Spatial Representation Extraction that can learn the representation of the network from a high-dimensional space. Additionally, to manage heterogeneity in the network, we have proposed an innovative Action Selection module that selects the appropriate traffic signal phases based on the specific structure of each intersection. To the best of our knowledge, our model is the first centralized control model implemented in a road network comprising thousands of intersections. Experimental results demonstrate the effectiveness of our approach in effectively managing massive-scale and heterogeneous road networks.
Matrix metalloproteinase 24 (MMP24) is a pro-fibrotic mediator in lung fibrosis
Authors: Gazdhar Amiq , Fytianos Kleanthis , Ozan Burak , Pfister Eliane , khan Petra , Boesch Maximilian , Baty Florent , Pantasis Sophia , Mykoniati Sofia , Bordoli Mattia , Rao Tata Nageswara , Brutsche Martin , Hostettler Katrin , Geiser Thomas 
Published: September 2024

Abstract

Idiopathic pulmonary fibrosis (IPF) represents a terminal, age-related disease characterized by a complex pathophysiology. Recent studies have reported the presence of basal cells in IPF lungs, yet their specific role and impact on other cell types within the fibrotic lung remains unclear. Lung resident mesenchymal stem cells (MSCs) are a crucial resident stem cell population essential for maintaining lung homeostasis; MSCs exhaustion, a hallmark of aging, has been implicated in IPF through poorly understood mechanisms. In this study, we investigated the effects of hepatocyte growth factor (HGF), an anti-fibrotic factor, on MSCs quiescence using a bleomycin-induced lung injury model. RNA-sequencing analysis of basal cells isolated from IPF lungs identified upregulation of matrix metalloproteinase 24 (MMP24) in IPF (2.45±0.53) compared to non-IPF basal cells (1.12±0.2) (p˂0.05). Moreover, in vivo experiments indicated increased MMP24 levels in bleomycin injured lung homogenates compared to healthy lungs (6.89±0.78 vs 3.52±0.65 ng/mL) p<0.01, and decreased frequencies of activated lung MSCs in bleomycin-injured lungs compared to healthy lungs (21.8±6.2% vs 51.0±9.3%) p<0.01. Consistently, in vivo overexpression of MMP24 resulted in enhanced quiescence of lung MSCs and increased fibrosis. Conversely, in vivo HGF gene transfer increased frequencies of activated lung MSCs (27.5±3.2%, p<0.05) and reduced MMP24 levels in lung homogenates (4.39±0.38 ng/mL, p<0.001). Mechanistically, HGF reduced MMP24 expression through the YAP-1 pathway. Collectively, our findings uncover MMP24 as a pro-fibrotic mediator in IPF patients and in bleomycin injured lung and identify HGF-YAP1-MMP24 as a novel therapeutic axis in lung fibrosis.
Cellulose Nanofibrils in Pervious Concrete: Improving Mechanical Properties and Durability
Authors: Li Jingchen , Cao Weidong , Yan Ziqi , Zhan Zunhao , Li Yingjian 
Published: September 2024

Abstract

Pervious concrete (PC), commonly used in urban pavement is known for its high permeability, which contributes to mitigating the urban heat island. However, the low strength and durability of PC limit its use. The objective of this study is to improve mechanical properties and durability of PC by adding cellulose nanofibrils (CNFs). The results showed that CNFs significantly enhanced compressive strength, flexural strength, and salt frost resistance, with optimal performance at 0.15% CNF. At this concentration, compressive and flexural strengths increased by 26.5% and 25.8%, respectively, despite a slight reduction in permeability. CNFs also improved resistance to salt-induced freeze-thaw cycles, reducing spalling and maintaining a higher dynamic elasticity modulus, particularly at 0.1% and 0.15% dosages. Scanning electron microscope (SEM) analyses revealed that CNFs create a denser, more uniform network of hydrated products, enhancing microstructure and interfacial bonding. This study confirms that CNFs can significantly enhance the mechanical properties and durability of PC.
Properties of a persuasive quit-smoking message based on the Elaboration Likelihood Model (ELM) from medical students’ perspective: A structured content analysis
Authors: Broujeni Razieh Beigi , Khademi Zahra , Ahmadi Zakieh 
Published: September 2024

Abstract

Background
Smoking is one of the biggest problems of the young generation. Several strategies have helped to reduce smoking among young people. ELM is a theoretical approach that provides guidance on developing messages that meet these needs. In this study, we decided to use the model of mental processing of beliefs as one of the effective approaches in persuasion, to investigate the process of persuasive messages to quit smoking in young people.
Method
The present study is a qualitative content analysis study that was conducted on 28 students. Structured interviews were used to collect data. Data analysis was done after each interview until data saturation was reached.
Findings:
28 students participated in this study. In this study,4 main issues of how to send the message, how to send it to the person, when to deliver the message, and the way/means of delivering the message were found. Out of the 12 extracted sub-classes,8 sub-classes were related to the peripheral path and 4 sub-classes were related to the central path of the model.
Conclusion
The views of medical students who are related to the future of society's health can be very valuable for smoking cessation.
Assessment of the Pb 2+ biosorption potential of the fungus Penicillium citrinum under geothermal conditions
Authors: Leins Alessio , Bregnard Danae , Schäpan Ilona , Zonneveld Wart , Bindschedler Saskia , Vieth-Hillebrand Andrea , Junier Pilar , Regenspurg Simona 
Published: September 2024

Abstract

One solution for reducing the scaling risk of lead (Pb)-containing phases is to remove the aqueous Pb2+ ions from the brine by a sorption process before oversaturation of Pb2+ phases at unwanted locations within the geothermal fluid loop. This study investigated the known capacity of fungal biomass to bind Pb2+ ions (biosorb) and thus remove Pb2+ from the brine. So far, biosorption studies have neither been done at high temperatures or salinity, nor under high pressure, three conditions that have to be considered within geothermal power plants. Thus, the overall goal of this study was to assess the Pb2+ biosorption potential of dead biomass of the fungus Penicillium citrinum strain HEK1 under conditions mimicking those of natural highly saline geothermal fluids. This specific strain was isolated from a geothermal power plant in which Pb2+ scaling occurs. The dead biomass of P. citrinum was added to synthetic solutions containing 260 g/L NaCl, 1g/L Pb, and (in half of the treatments) 60 mg/L acetic acid. These synthetic solutions, including the dead biomass, were then incubated at high pressure (8 bar) at different temperatures (25°C, 60°C, 98°C) and for different time intervals (1 h, 2 h, 3 h). Results showed that the biomass was stable in such conditions, at all temperatures tested, but small amounts of organic compounds, with a wide variety of low molecular weight (< 350 Da to 10,000 Da) have been released into the fluids from the biomass. In general, increased temperature resulted in an increase of dissolved organic carbon (DOC) concentration. Moreover, the potential for biosorption of P. citrinum HEK1 biomass was not affected by changes in temperature, time of exposure or by the presence of organic acids within the fluids. However, the biosorption potential was overall low (1.4% of total Pb2+). It nevertheless increased to about 5 to 10% of Pb2+ removal in experiments with non-saline conditions. Therefore, the high salinity of the fluids was the factor limiting the biosorption to the highest extent, highlighting that working with highly saline geothermal fluids might be limiting for biosorption processes to happen efficiently.
Adolescent depression treatment pathways in Primary Care – protocol for a longitudinal Cohort Study Describing Naturalistic Flow of Treatment and Evaluating Effectiveness and Cost- effectiveness of Interpersonal Counseling Compared to Treatment as Usual
Authors: Linnaranta Outi , Myllyniemi Aija , Salusjärvi Emma , Seilo Noora , Kaljadin Jasmin , Kukko Tiia-Reeta , Tani Sara , Kaltiala Riittakerttu , Koskinen Tarja , Karukivi Max , Karvonen Juha T. , Karri Sirene , Oksanen Juha , Heinonen Erkki , Kiviruusu Olli , Therman Sebastian , Berg Päivi , Lahti Jari , Rissanen Elisa , Lammintakanen Johanna , Ranta Klaus , Autio Reija , Marttunen Mauri 
Published: September 2024

Abstract

Background:Implementation of evidence-based interventions is one of the proposed responses to increased demand for treatment of adolescent depression. While the efficacy of interpersonal psychotherapy to treat depression of adolescents (IPT-A) is well established, the effectiveness and cost-effectiveness of the shorter adolescent interpersonal counseling (IPC-A) remains open.
Objective: We present a protocol for a prospective evaluation of the naturalistic treatment flow of adolescents with sustained depression, and effectiveness and cost-effectiveness of IPC-A, as compared to treatment as usual or no treatment of sustained depression.
Methods: We will collect a prospective cohort of grade 7 to 9 adolescents (13–16-year-olds) in selected Finnish schools using convenience sampling (n=9000). We will compare three groups as defined at 6 months (targeting with IPC-A, n=100; with treatment as usual (TAU), n=200; or no treatment, n=100). The primary outcome measure will be the proportion of adolescents who received specialized psychiatric services by 2 years after baseline. Secondary outcome measures will include longitudinal changes in PHQ-9-A scores by 12 months, positive mental health, social inclusion, and quality of life. Cost-effectiveness will be evaluated using survey data at 12 months, and an economic evaluation using register data and information on service use 12 months before and up to 10 years after baseline. A universal evaluation of all adolescents, independent of mood, will provide prospective description of adolescents a) with sustained depression over the follow-up period (Patient Health Questionnaire 9 items, adolescent version, PHQ-9-A ≥ 10 in two measurements over 6 months), b) with a self-reported need and motivation for support, c) with therapeutic intervention, and d) benefits and harms of treatment. We will describe the treatment received and predictors of treatment and outcome based on reports from adolescents, caretakers, and therapists, as well as electronic patient records. Impact of training in IPC-A on competence and access to treatment will be evaluated.
Conclusions: The study will describe need for, pathways to, and content of mental health services for depressed adolescents. The results can improve detection and equal access to care, and inform decision -makers about the best practices for prevention, including utility of the implementation of IPC-A.
Trial registration: ClinicalTrials.com NCT06390462 registered 2024-03-19
Investigation of the toughness behavior in cold-formed and welded high-strength steels using fracture mechanics concepts and notch impact test
Authors: Werner Tom , Nitschke-Pagel Thomas , Dilger Klaus 
Published: September 2024

Abstract

High-strength steels are increasingly utilized across various industrial sectors, notably in statically loaded components such as crane constructions. These steels are frequently subjected to cold forming during production, followed by welding. However, welding in cold-formed regions of structural steels often results in embrittlement, thereby elevating the risk of brittle fracture. Current standards like Eurocode 3 address this phenomenon by prescribing a minimum distance of five times the plate thickness for welding in cold-formed areas of structural steels with a minimum yield strength of 700 MPa. Failure to meet this minimum distance necessitates costly heat treatment processes. This article investigates three steels with higher yield strengths ranging from 700 MPa to 1100 MPa, featuring diverse strengths and manufacturing variations, to elucidate the influence of embrittlement during cold forming and welding of high-strength steels utilizing concepts from fracture mechanics. The results indicate that embrittlement is not anticipated in the cold-formed and welded regions of high-strength steels. It is inferred that the absence of secondary recrystallization, attributed to the existing microstructure or fine grain size of the steels, mitigates the formation of coarse grains, thereby averting brittle fracture.
Bidirectional analysis of gastroesophageal reflux disease and migraine using two-sample Mendelian randomization
Authors: Jin Xin , Zhuang Jianhua , Xu Jin 
Published: September 2024

Abstract

Background
Epidemiological studies suggest a link between gastroesophageal reflux disease (GERD) and migraine, but the causal relationship remains unclear. This study aimed to clarify this relationship using two-sample Mendelian Randomization (MR).
Methods
Data on GERD and migraine, including subtypes with aura (MA) and without aura (MO), were collected from genome-wide association studies (GWAS). SNPs were selected as instrumental variables (IVs) by accounting for linkage disequilibrium and removing unbalanced connections. The primary analysis used the inverse variance-weighted (IVW) method with supplementary analyses. Heterogeneity and pleiotropy were assessed using Cochran's Q test, MR-Egger intercept, and MR-PRESSO. Finally, reverse causality was explored.
Results
The IVW method indicated a causal link between GERD and increased risk of migraine (OR = 1.381, 95% CI: 1.190–1.602, p = 2.04E-05), particularly the MO subtype (OR = 1.600, 95% CI: 1.311–1.953, p = 3.67E-06). No significant association was found for MA (OR = 1.193, 95% CI: 0.983–1.449, p = 0.074). Reverse MR analysis showed no causal relationship between migraine and GERD.
Conclusion
GERD is causally linked to an increased risk of migraine, especially the MO subtype. No reverse causal relationship was found, highlighting the importance of considering migraine subtypes in understanding their association with GERD.
A Jamming Risk Warning Model for TBM tunnelling Based on Bayesian Statistical Methods
Authors: Wang Shuang-jing , Wang Le-chen , Wu Lei-jie , Li Xu 
Published: September 2024

Abstract

This study presents a comprehensive jamming risk assessment framework for Tunnel Boring Machine (TBM) jamming accidents during excavation. Using real-time boring data and Bayesian conditional probability, a novel risk warning model is proposed to enhance safety and efficiency of tunneling projects. Through statistical analysis of excavation parameters, distinct patterns between jamming and normal excavation states are identified. A comprehensive jamming perception index (η) is introduced that synthesizes multiple parameters to accurately identify jamming states with a recognition rate of 95%. This integrated approach overcomes the limitations of single-parameter analysis and provides improved accuracy in jamming risk assessment. Additionally, a quantitative model for calculating jamming probability is developed, accounting for differences in sample size between jamming and normal excavation sections. The refined model yields realistic estimates of jamming probability, with an average of 94% in jamming sections and 7% in normal excavation sections. Furthermore, geological analysis shows that the Class Ⅲ surrounding rock is the most suitable for excavation and has the lowest jamming probability. This finding emphasizes the importance of considering geological conditions in excavation planning to effectively mitigate jamming risks. In conclusion, this research provides a practical framework for the prediction and management of TBM jamming accidents, contributing to enhanced safety and efficiency in tunneling projects.
Global Burden of Parkinson’s Disease from 1990 to 2021: A Population-Based Study
Authors: Mimi  , Xiaofang  , Hua Zhengping , Lichao  , Chen Chunnuan 
Published: September 2024

Abstract

Background
Parkinson’s disease (PD) has become a public health concern with global aging.With a focus on PD, this study sought to project its burden and trends at the national, regional, and worldwide levels between 1990 and 2021.
Methods
The Global Burden of Disease 2021 provided the PD burden data. The age-standardized rate (ASR) and annual percentage change (EAPC) were used to estimate trends in the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of PD from 1990 to 2021. ASR was used to calculate the EAPCs using a linear regression model.A Bayesian age-period-cohort (BAPC) model was used to predict future trends up to 2046.
Results
Globally, the overall ASR of the incidence, prevalence,DALYs and mortality of PD increased from 1990 to 2021, and their EAPCs were 1.09 (95% confidence interval [CI]: 1.07–1.11), 1.52(95CI:1.49–1.54),0.32 (95% CI: 0.28–0.36) and 0.18(95% CI: 0.13–0.23).The incidence, prevalence, mortality, DALYs, of PD in 2021 were all higher in men than in women.From 1990 to 2021, the burden in males consistently surpassed that in females, with the gender difference widening as age.The prevalence,incidence,DALYs and mortality rates of PD increased with age before declining, peaking in the 80–84 age group for prevalence and incidence ,while in the 90–94 age group for mortality. peaked in the 85–89 age group for DALY rates. The ASR of incidence and prevalence both increased pronouncedly in Norway (EAPC = 3.39,95% CI: 3.15–3.64),(EAPC = 5.04,95%CI: 4.65–5.43).Lesotho was the nation with the most rise in age-standardized DALYs for PD (EAPC = 1.67, 95%CI༚1.41–1.93).United Arab Emirates had the fastest increase in age-standardized mortality for PD (EAPC = 1.98,95%:1.24–2.71).The global ASPR of PD was projected to show a continuous upward trend.
Conclusions
From 1990 to 2019, there were rising trends in the prevalence and burden of PD in most areas and nations worldwide. Our research indicated that PD control and management needed to be improved, particularly in light of the population's propensity to age.