bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enzymatic preparation of diacylglycerols: lipase screening, immobilization, characterization and glycerolysis performance
Authors: Xie Rui , Peng Xianwu , Lee Yee‐Ying , Xie Pengkai , Tan Chin‐Ping , Wang Yong , Zhang Zhen 
Published: September 2024

AbstractBackgroundsGlycerolysis, with its advantages of readily available raw materials, simple operation, and mild reaction conditions, is a primary method for producing diacylglycerol (DAG). However, enzymatic glycerolysis faces challenges such as high enzyme costs, low reuse efficiency, and poor stability. The study aims to develop a cost‐effective immobilized enzyme by covalently binding lipase to pre‐activated carriers through the selection of suitable lipases, carriers, and activating agents. The optimization is intended to improve the glycerolysis reaction for efficient DAG production.ResultsLipase CN‐TL (from Thermomyces lanuginosus) was selected through glycerolysis reaction and molecular docking to catalyze the glycerolysis reaction. Optimizing the immobilization method by covalently binding CN‐TL to poly(ethylene glycol) diglycidyl ether (PEGDGE)‐preactivated resin LX‐201A resulted in the preparation of the immobilized enzyme TL‐PEGDGE‐LX. The immobilized enzyme retained over 90% of its initial activity after five consecutive reactions, demonstrating excellent reusability. The DAG content in the product remained at 84.8% of its initial level, further highlighting the enzyme's potential for reusability and its promising applications in the food and oil industries.ConclusionsThe immobilized lipase TL‐PEGDGE‐LX, created by covalently immobilizing lipase CN‐TL on PEGDGE‐preactivated carriers, demonstrated broad applicability and excellent reusability. This approach offers an economical and convenient immobilization strategy for the enzymatic glycerolysis production of DAG. © 2024 Society of Chemical Industry.
Systemic chemotherapy in addition to CRS‐HIPEC for colorectal peritoneal metastases: A critical systematic review on the impact on overall survival
Authors: van den Heuvel Teun B. M. , Lurvink Robin J. , Rovers Koen P. B. , van Hellemond Irene E. G. , de Hingh Ignace H. J. T. 
Published: September 2024

AbstractIn patients with resectable colorectal peritoneal metastases, it is unclear whether systemic chemotherapy, in addition to cytoreductive surgery‐hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC), improves overall survival (OS). This systematic review of 12 retrospective studies involving 3721 patients aimed to summarize the available evidence. Contradictory results were found regarding the effectiveness of neoadjuvant, adjuvant, and perioperative systemic therapies on OS, with a high risk of bias. Available evidence remains inconclusive, stressing the need for prospective, randomized trials, like the ongoing Dutch CAIRO6‐trial.
Comparison of Prognostic Performance of 8th and 7th Edition of AJCC Staging System for Patients With Gallbladder Cancer Undergoing Curative Intent Surgery
Authors: Gupta Sameer , Verma Abhishek , Chaturvedi Arun , Prakash Puneet , Kumar Vijay , Misra Sanjeev , Akhtar Naseem , Rajan Shiv , Agarwal Preeti , Smith Lynette , Schissel Makayla , Are Chandrakanth 
Published: September 2024

ABSTRACTBackgroundWe compared the predictive performance of the 7th and 8th editions of the AJCC staging systems in stratifying disease‐related survival outcomes in patients with GBC undergoing curative intent surgery.MethodsPatients that underwent curative intent surgery for GBC at our institution (2014 and 2021) were included in the study. Various clinico‐pathological data were extracted to perform Kaplan–Meier survival analysis.ResultsA total of 240 patients were included in the study. Both, TNM‐7, and TNM‐8 staging systems can stratify patients into stages with statistically significant differences in disease‐free and overall survival. Survival rates drop with stage progression. Using TNM‐8, 8/240 (3.33%) patients were upstaged from Stage IIIB (TNM‐7) to IVB (TNM‐8) and 12/240 (5%) were down‐staged from Stage IVB(TNM‐7) to IIIB(TNM‐8). Survival curves of the re‐classified patients matched those of the corresponding TNM‐8 stage. Additionally, there was statistically significant difference in their survival (p < 0.001) compared to their corresponding TNM‐7 stage. There was no statistically significant difference in survival rates between stages IIA, IIB (TNM‐8), and stage II (TNM‐7). However, stage IIA had a slightly better survival than stage IIB.ConclusionThough both TNM‐7 and TNM‐8 are useful for stratifying patients with GBC, TNM‐8 has a better prognostic performance than TNM‐7.
Perfusion Strategies for Cytoreductive Surgery With Heated Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma
Authors: Drigotas Claire , Loftus Alexander W. , Ammori John B. , Rothermel Luke D. , Hoehn Richard S. 
Published: September 2024

ABSTRACTCytoreductive surgery (CRS) with heated intraoperative intraperitoneal chemotherapy (HIPEC) has been shown to improve survival for patients with malignant peritoneal mesothelioma (MPM). Presently, there is no standardized HIPEC protocol with respect to chemotherapeutic agent, dose, administration temperature, or duration and limited literature comparing outcomes in different regimens. In this study, we analyze common practices and outcomes of published HIPEC regimens to gain insight into current practice to inform future directions of study. We conducted a literature search for investigational studies of CRS and HIPEC for MPM treatment in adults and identified 35 such articles. These studies were analyzed for institution type and location, drug regimens, perfusion temperatures and time, and study outcomes including median survival, complication rates, and perioperative mortality rates. On review, there is significant heterogeneity in HIPEC regimens and outcome reporting metrics, suggesting a need for multi‐institutional standardized study protocols to better determine the safest and most efficacious treatment regimen.
The reliability of multi‐source data linkage for population‐based cancer survival estimates: A study in a metropolitan cancer registry of China
Authors: Shen Yubing , Fu Ruiying , Wang Xiaofeng , Zhang Xinyu , Zhou Ying , Zhou Yiheng , Liu Jue , Mei Dan , Han Bingfeng , Li Li , Wang Shaoming , Chen Ru , Sun Kexin , Lin Hong , Mu Huijuan , Sun Ke , Zeng Hongmei , Wei Wenqiang 
Published: September 2024

AbstractBackgroundPopulation‐based cancer survival is a key metric in evaluating the overall effectiveness of health services and cancer control activities. Advancement in information technology enables accurate vital status tracking through multi‐source data linkage. However, its reliability for survival estimates in China is unclear.MethodsWe analyzed data from Dalian Cancer Registry to evaluate the reliability of multi‐source data linkage for population‐based cancer survival estimates in China. Newly diagnosed cancer patients in 2015 were included and followed until June 2021. We conducted single‐source data linkage by linking patients to Dalian Vital Statistics System, and multi‐source data linkage by further linking to Dalian Household Registration System and the hospital medical records. Patient vital status was subsequently determined through active follow‐up via telephone calls, referred to as comprehensive follow‐up, which served as the gold standard. Using the cohort method, we calculated 5‐year observed survival and age‐standardized relative survival for 20 cancer types and all cancers combined.ResultsCompared to comprehensive follow‐up, single‐source data linkage overestimated 5‐year observed survival by 3.2% for all cancers combined, ranging from 0.1% to 8.6% across 20 cancer types. Multi‐source data linkage provided a relatively complete patient vital status, with an observed survival estimate of only 0.3% higher for all cancers, ranging from 0% to 1.5% across 20 cancer types.ConclusionMulti‐source data linkage contributes to reliable population‐based cancer survival estimates in China. Linkage of multiple databases might be of great value in improving the efficiency of follow‐up and the quality of survival data for cancer patients in developing countries.
Success Rate and Predicting Factors for Repeated High‐Dose Intradetrusor Dysport Injections in Children With Neurogenic Bladder: A Retrospective Study
Authors: Ventura Yossi , Morag Roy , May Tal , Khunovitz Dmitry , Ben Meir David 
Published: September 2024

ABSTRACTObjectivesEvaluating the effectiveness and safety of repeated high‐dose intradetrusor abobotulinumtoxin A (Dysport®) injections for the treatment of pediatric neurogenic bladders refractory to medications.DesignRetrospective interventional study.ParticipantsThe cohort included 37 children (22 boys and 15 girls) of median age 9.2 years. Inclusion criteria were diagnosis of neurogenic bladder and failure to respond to medical treatment. Exclusion criteria were augmented bladder, insufficient data, and interval of > 11 months between video‐urodynamic study and Dysport injection.InterventionsAll participants were treated with an intra‐detrusor injection of Dysport 30 IU/kg (up to 1000 IU) under general anesthesia. Repeated (second and third) injections were scheduled (6–12 months) in patients who demonstrated an improvement in cystometric parameters. All participants underwent video urodynamic testing before onset of treatment and 4–5 months after subsequent injection.Main Outcome MeasuresSuccess of treatment was defined as a decrease in end filling pressure (EFP) to < 40 cm H2O and/or a 20% increase in maximal cystometric capacity (MCC). These parameters along with initial bladder features were evaluated for ability to predict treatment success.ResultsNo side effects of Dysport were observed or reported. The overall success rate was 62%. MCC increased by a median of 30% (IQR 200–300, p < 0.001), 37% (IQR 197–310, p = 0.001) and 45% (IQR 245–300, p = 0.025) after the first, second and third injections, respectively. Median EFP decreased from 45 cm H2O to 34 cm H2O (IQR 20–45, p = 0.029), 23 cm H2O (IQR 20–37, p = 0.004), and 20 cm H2O (IQR 12–32, p = 0.049) after the first, second, and third injections, respectively. No predicting factor of success of treatment were found; However, three of five cases of “end stage” bladder showed improvement.ConclusionsHigh‐dose Dysport injection is safe and effective for the treatment of neurogenic bladder. Studies with larger cohort and a control group would further elucidate which bladders would benefit most. At present, we recommend treating also bladders with “end stage” features with botulinum toxin before considering augmentation.
A Family of Inertial Three‐Term CGPMs for Large‐Scale Nonlinear Pseudo‐Monotone Equations With Convex Constraints
Authors: Jian Jinbao , Huang Qiongxuan , Yin Jianghua , Ma Guodong 
Published: September 2024

ABSTRACTThis article presents and analyzes a family of three‐term conjugate gradient projection methods with the inertial technique for solving large‐scale nonlinear pseudo‐monotone equations with convex constraints. The generated search direction exhibits good properties independent of line searches. The global convergence of the family is proved without the Lipschitz continuity of the underlying mapping. Furthermore, under the locally Lipschitz continuity assumption, we conduct a thorough analysis related to the asymptotic and non‐asymptotic global convergence rates in terms of iteration complexity. To our knowledge, this is the first iteration‐complexity analysis for inertial gradient‐type projection methods, in the literature, under such a assumption. Numerical experiments demonstrate the computational efficiency of the family, showing its superiority over three existing inertial methods. Finally, we apply the proposed family to solve practical problems such as ‐regularized logistic regression, sparse signal restoration and image restoration problems, highlighting its effectiveness and potential for real‐world applications.
Clinical effectiveness of paliperidone palmitate 3‐monthly and 1‐monthly as monotherapy in patients with schizophrenia: A retrospective cohort study based on the Medicaid claims database
Authors: Chiang Chih‐Lin , Chinen Madoka , Daskiran Mehmet , Wakamatsu Akihide , Turkoz Ibrahim 
Published: September 2024

AbstractAimReal‐world data (RWD) for paliperidone palmitate (PP) three‐monthly (PP3M) is lacking based on Japan label requirements. This study evaluated the clinical effectiveness of PP3M versus PP once‐monthly (PP1M) in patients with schizophrenia administered according to Japan label requirements.MethodsRetrospective analyses were conducted using RWD from Merative™ MarketScan® Multi‐State Medicaid (MDCD) claims database (June 2015–December 2022). Adult patients with schizophrenia switching from PP1M to PP3M were included. Patients transitioning to PP3M were matched with patients who continued with PP1M using propensity score matching (PSM) at 1:1 ratio. Primary hypothesis aimed to investigate non‐inferiority of PP3M versus PP1M in terms of relapse‐free status at 24 months from index PP injection. Outcome measures were proportions of relapse‐free patients at 24 months, time to relapse, treatment persistence, and adherence.ResultsTotal 4252 eligible adult schizophrenia patients on PP (PP3M:582; PP1M:3670) were identified. After PSM, each PP cohort comprised 562 matched individuals. Estimated proportion of relapse‐free patients was higher in PP3M (85.7%) versus PP1M (77.9%), per Japan PP label. PP3M demonstrated superiority to PP1M after testing for non‐inferiority in terms of achieving relapse‐free status at 24 months, with an estimated difference of 7.8% (95% CI: 1.7%–13.9%). PP3M cohort had lower risk of relapse (HR: 0.605; CI: 0.427–0.856), longer treatment persistence, and higher treatment adherence versus PP1M cohort.ConclusionsFindings suggests that patients who switched to PP3M might be able to reduce risk of relapse compared to those who continued PP1M after aligning particularly with Japan's label requirements.
Hybrid modeling of multibody systems: Comparison of two discrepancy models for trajectory prediction
Authors: Wohlleben Meike , Röder Benedict , Ebel Henrik , Muth Lars , Sextro Walter , Eberhard Peter 
Published: September 2024

AbstractThis study focuses on hybrid modeling approaches that combine physical and data‐driven methods to create more effective dynamical system models. In particular, it examines discrepancy models, a type of hybrid model that integrates a physical system model with data‐driven compensation for inaccuracies. The study applies two discrepancy modeling methods to a multibody system using discrepancies in the state vector and its time derivative, respectively. As an application example, a four‐bar linkage with nonlinear damping is investigated, using a simplified conservative system as a physical model. The comparative analysis of the two methods shows that the continuous approach generally outperforms the discrete method in terms of accuracy and computational efficiency, especially for velocity prediction and prediction horizon. However, scenarios, where input signals for training and testing differ, present nuanced findings. When the continuous method is trained on complex signals (sine) and tested on simpler ones (stair), it struggles to deliver satisfactory results, exhibiting notably higher root mean square error (RMSE) values, particularly in angular velocity prediction. Conversely, training on simple signals (stair) and testing on complex ones (sine) surprisingly yields low RMSE values, indicating the continuous method's adaptability. While the discrete method aligns more closely with expectations and performs better in certain scenarios, its results are consistently moderate, neither exceptional nor particularly poor. The study also introduces a selection framework for choosing the most suitable algorithm based on the specific characteristics of the modeling task. This framework provides guidance for researchers and practitioners in leveraging hybrid modeling effectively. Finally, the study concludes with an outlook on future research directions.
The effect of active leg swing on walking template model dynamics
Authors: Renjewski Daniel 
Published: September 2024

AbstractSome reductionist models match human walking dynamics surprisingly well. For reasons of simplicity, the swing leg and its dynamics have been neglected in the past. A dynamic effect would, however, be expected of the high acceleration and deceleration required to recirculate approximately 15% of the entire body mass during the very short swing phase. This paper documents the investigation of the effect of a simplified swing leg on the dynamics of a reductionist walking model. The findings suggest the dynamic decoupling of the swing leg and the remaining body.
Analysis and simulation of curved hoses under internal pressure—3D continuum models
Authors: Hoesch Quirin , Roller Michael , Schneider‐Jung Fabio , Linn Joachim , Müller Ralf 
Published: September 2024

AbstractThis contribution aims to model and characterize the nonlinear elastic behavior of hoses under internal pressure. A highly resolved 3D continuum model is used to identify relevant effects of preformed hoses under internal pressure. The focus of this work is on the Bourdon effect, which is illustrated by simulating two simplified models, a full torus and a quarter torus. For a full torus, the Bourdon effect can be observed by the fact that the radius of curvature increases in addition to the expansion of the cross‐sectional radius. For a quarter torus, which is a simplified example of a curved hose, the Bourdon effect can be observed by the tendency of the hose to straighten under internal pressure. Furthermore it is detected for both examples that the non‐constant distribution of the poloidal (hoop) stress over the cross‐section leads to an ovalization behavior. In addition, the model of a quarter torus is extended to a more complex model with straight hose sections at both ends.
SNPscan Combined With CNVplex as a High‐Performance Diagnostic Method for Thalassemia
Authors: Wei Xiaofeng , Wang Xingmin , Xiong Fu , Zhang Xinhua , Liu Dun , Zhou Wanjun , He Fei , Shang Xuan 
Published: September 2024

ABSTRACTObjectiveThalassemia is a Mendelian‐inherited blood disorder with severe consequences, including disability and mortality, making it a significant public health concern. Therefore, there is an urgent need for precise diagnostic technologies. We introduce two innovative diagnostic techniques for thalassemia, SNPscan and CNVplex, designed to enhance molecular diagnostics of thalassemia.MethodsThe SNPscan and CNVplex assays utilize variations in PCR product length and fluorescence to identify multiple mutations. In the SNPscan method, we designed three probes per locus: two 5′ and one 3′, and incorporated allele identification link sequences into one of the 5′ probes to distinguish the alleles. The detection system was designed for 67 previously reported loci in the Chinese population for a specific genetic condition. CNVplex identifies deletion types by analyzing the specific positions of probes within the globin gene. This innovative approach enables the detection of six distinct deletional mutations, enhancing the precision of thalassemia diagnostics. We evaluated and refined the methodologies in a training cohort of 100 individuals with confirmed HBA and HBB genotypes. The validation cohort, consisting of 1647 thalassemia patients and 100 healthy controls, underwent a double‐blind study. Traditional diagnostic techniques served as the control methods.ResultsIn the training set of 100 samples, 10 mutations (Hb QS, Hb CS, Hb Westmead, CD17, CD26, CD41‐42, IVS‐II‐654, ‐‐SEA, −α3.7 and −α4.2) were identified, consistent with those identified by traditional methods. The validation study showed that SNPscan/CNVplex offered superior molecular diagnostic capabilities for thalassemia, with 100% accuracy compared to 99.43% for traditional methods. Notably, the assay identified three previously undetected mutations in 10 cases, including two deletion mutations (Chinese Gγ(Aγδβ)0 del and SEA‐HPFH), and one non‐deletion mutation (Hb Q‐Thailand).ConclusionsThe SNPscan/CNVplex assay is a cost‐effective and user‐friendly tool for diagnosing thalassemia, demonstrating high accuracy and reliability, and showing great potential as a primary diagnostic method in clinical practice.
Understanding anxiety‐related problems of children with ASD in school settings
Authors: Perihan Celal , Bicer Ali , Bocanegra Joel 
Published: September 2024

AbstractThe primary purpose of this current study was to identify knowledge of special education and mental health professionals in anxiety‐related problems of children with autism spectrum disorder (ASD) in four Different Categories: Separation Anxiety (SA), Uncertainty (U), Performance Anxiety (PA), and anxiety Arousal (AA). Three hundred eighteen participants across the United States (199 special education teachers, 97 school counselors, and 22 school psychologists) participated. The finding indicated that special education teachers and school counselors have significantly less training and expertise to identify anxiety symptoms in typically developing children and children with ASD than school psychologists (p < .05). Moreover, school counselors have significantly limited knowledge in identifying and treating anxiety issues in children with ASD (p < .05). Findings showed that school counselors could not determine precisely whether symptoms of uncertainty events existed because of anxiety issues or ASD characteristics. School psychologists and special education teachers identified the uncertainty of children with ASD as characteristics of children with ASD, not anxiety symptoms. Implications were discussed.
Parkinson's and Lewy Body Dementia: Can It Be Something Else?
Authors: Andonova Dilyana , Doukova Ekaterina 
Published: September 2024

ABSTRACTUnexplained psychopathologies, although intriguing for the inquisitive clinician, pose significant diagnostic and treatment challenges. In such cases, looking beyond what is evident and logical might just be the answer. This case report reflects on a patient with a diagnosis of Parkinson's disease and Lewy body dementia, with an unusual set of symptoms and disease progression. It also explores the possibility of an overlap of clinical features associated with recent exposure to gadolinium contrast agent and its possible implications in the brain tissue and the subsequent neuropsychiatric symptoms.