bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low Doses of Innate Defence Regulator Peptide, IDR-1018, Enhances HDL-Mediated Cholesterol Efflux from Smooth Muscle Cells and Macrophages
Authors: NJ Afacan , T Chan , J Pistolic , J Kong , GA Francis , REW Hancock 
Published: December 2016

Cardiovascular diseases due to atherosclerosis are the leading cause of death worldwide. In recent years, novel therapeutics designed to enhance high-density lipoprotein (HDL) activity as a treatment for atherosclerosis have been explored. Of particular interest is the use of amphipathic Î±-helical peptides to mimic the action of the main HDL protein, apolipoprotein (Apo)AI. Immunomodulatory peptides share many physical and functional
properties with ApoAI and its mimetics; we therefore hypothesized that they too might be capable of enhancing cholesterol efflux. The aim of this study was to determine whether a potent immunomodulatory peptide, innate defence regulator (IDR)-1018, could promote cholesterol efflux from cells. Here, we report that IDR-1018 induced a dose-dependent increase in ApoAI on the cell surface and ATP-binding cassette transporter A1 (ABCA1)
protein levels. Functional assays revealed that low doses of IDR-1018 improved HDL-mediated suppression of intracellular cholesteryl ester accumulation in macrophages and enhanced HDL-mediated cellular cholesterol efflux from smooth muscle cells and macrophages. Based on these results we propose that natural and synthetic immunomodulatory peptides like IDR-1018 represent a large new group of peptides that could be developed for
the treatment of atherosclerosis.
Assessment of a Correlation between Malnutrition, Serum Hypotransferrin and Chronic Skin Ulcers
Authors: A Crisci , M Crisci , L Pollastro 
Published: December 2016

The aims of this study were to evaluate the correlation between malnutrition, serum hypotransferrin and chronic skin ulcers and the effect of supplementation with a dietary integrator on wound healing. The study
population was 20 patients with chronic skin ulcers (12 men and 8 women; mean age 75.58 Â± 8.51 years). Monthly assessments were carried out for 6 months (V1-V6) and comprised measurement of changes in wound surface area and blood chemistry parameters (hemoglobin [Hb], total proteins, albumin, transferrin, iron, total iron-binding capacity [TIBC], latent iron-binding capacity [LIBC], transferrin saturation index). Nutritional supplementation with an oral dietary integrator was initiated at day 45. At day 45, the mean blood chemistry values were: serum albumin
2.73 Â± 1.07 g/dL (45.05 Â± 15.84%); total proteins 6.35 Â± 0.65 g/dL; total lymphocyte count 24.17 Â± 0.09%; serum Hb 10.86 Â± 1.47 g/dL; serum trasferrin 165.92 Â± 75.95 g/dL; serum iron 40.5 Â± 19.65 mg%; TIBC 207.4 Â± 94.94 mgr%; LIBC 166.9 Â± 92.45 mg%; transferrin saturation index 20.63 Â± 9.73%. These values indicated moderate protein malnutrition. The mean wound surface area was 56.92 Â± 47.95 cm2. At 90 days (V4) the mean values were: serum albumin 3.43 Â± 0.68 g/dL (48.05 Â± 8.15%); serum proteins 6.91 Â± 0.51 g/dL; total lymphocyte count 40.44
Â± 0.44%; serum Hb 12.47 Â± 1.91 g/dL; serum trasferrin 223.73 Â± 104.07 g/dL; serum iron 51.09 Â± 22.66 mgr%; TIBC 279.66 Â± 130.09 mgr%; LIBC 228.57 Â± 133.37 mgr%; transferrin saturation index 21.54 Â± 12.15%. The mean wound surface area was 20.41 Â± 25.91 cm2. In conclusion, a correlation emerged between hypotransferrinemia
and chronic skin ulcers, as demonstrated by the improvement in both parameters with treatment. Supplementation with the oral dietary integrator led to an increase in serum transferrin, and particularly in serum Hb and proteins and total lymphocyte counts, stimulating the healing of the chronic skin ulcers.
Understanding how a law clinic can contribute towards students’ development of professional responsibility
Authors: Thanaraj Ann 
Published: December 2016

<p><em>There is rich international literature spanning over decades giving valuable insights into the educational benefits of Clinical Legal Education (CLE), however there is little in the way of empirical data evaluating the link between utilizing CLE to develop specific skills. This paper aims to discover the link between CLE as a learning methodology and the extent to which students become more aware of professional responsibility skills after a clinical experience. The study employed a phenomenographic methodology to evaluate the variations in student learning. The findings suggest that students believe they have developed a greater sense of awareness and learning of a variety of lawyering skills and a greater awareness of values and characteristics of a competent lawyer through the clinical experience. </em></p>
The Demonization of Woman in Femi Osofisan’s Women of Owu
Authors: NNANNA Ndubuisi 
Published: December 2016

<p>Critical opinions on Femi Osofisan’s Women of Owu are largely stereotypical. They lament the plunder of Owu and compare it to that of Troy, drawing some parallels between Euripides’ The Trojan Women and Osofisan’s adaptation of it. There is a clear effort to assume some kind of historical and cultural affinity between the women of ancient Owu and Troy. But most of these assumptions are apparently contrived. It seems that there has been no attempt to consider Osofisan’s play in its own right. This study is an endeavor in that direction. It adopts the Reader-Response approach as a methodology to conduct a phenomenological analysis of Osofisan’s Women of Owu in order to discover the extent to which it truly reflects the picture of the Owu war of the 17th century and portrays the cultural identity of the women of Owu. It also compares Euripides’ play with Osofisan’s version in the context of their individual historical backgrounds to examine how each play captures the realities of its specific cultural milieu. The conclusion of this paper is that in an attempt to find parallels to the source of his play, Osofisan has inadvertently extrapolated the cultural essence of a society that had little regard for women into the cultural history of an African community, where women had a lot of respect, and in the process, has demonized womanhood and given impetus to some flawed assumptions and misinterpretations of history. The recommendation of this paper is, therefore, that African dramatists should be conscious of the peculiarities of cultures and the danger in attempting to find contrived affinities between African and Western cultures in an effort to lend some kind of credibility to their creative endeavors.<em> </em></p>
Avaliação dos fatores de risco maternos em gestantes admitidas com pré-eclâmpsia grave<br>doi: 10.20513/2447-6595.2016v56n2p25-29
Authors: Santos Nilce Ariane Spencer , Gurgel Julio Augusto Alves , Camurça Carla Gurgel 
Published: December 2016

OBJETIVOS: Avaliar os fatores associados ao diagnóstico de pré-eclâmpsia (PE) precoce ou tardia. MATERIAL E MÉTODOS: estudo retrospectivo com 208 gestações com PE na Maternidade Escola Assis Chateaubriand – Universidade Federal do Ceará, no período de um ano (2014 a 2015). O diagnóstico e a gravidade da doença basearam-se nos níveis pressóricos, proteinúria, dados clínicos e laboratoriais. Os fatores de risco considerados foram idade, paridade, histórico de PE em gestação anterior ou na família, níveis pressóricos, dopplervelocimetria. A PE foi considerada pré-eclâmpsia início precoce (PEP) quando diagnosticada antes da 34ª semana e pré-eclâmpsia de início tardio (PET) após a 34ª semana. RESULTADOS: Das 208 pacientes analisadas, obtivemos 156 (75%) casos de PET e 52 (25%) de PEP. Entre as primíparas (123), 62,8% eram PET (p=0,06). Pacientes que iniciaram o pré-natal com níveis pressóricos mais elevados tiveram maior incidência de PEP. CONCLUSÃO: Dos fatores de risco mais associados com PE grave, observou-se que a Hipertensão arterial crônica foi o mais prevalente; e, dos fatores de risco moderado, a primiparidade, a história prévia de doença hipertensiva em gestação anterior e o Índice Massa Corporal (IMC) elevado foram os mais encontrados. Pacientes que iniciam pré-natal com níveis pressóricos elevados ou hipertensão prévia tem maior risco de desenvolver PEP.
Effect of Medicaid Expansion on Workforce Participation for People With Disabilities
Authors: Hall Jean P. , Shartzer Adele , Kurth Noelle K. , Thomas Kathleen C. 
Published: December 2016

Objectives. To use data from the Health Reform Monitoring Survey (HRMS) to examine differences in employment among community-living, working-age adults (aged 18–64 years) with disabilities who live in Medicaid expansion states and nonexpansion states. Methods. Analyses used difference-in-differences to compare trends in pooled, cross-sectional estimates of employment by state expansion status for 2740 HRMS respondents reporting a disability, adjusting for individual and state characteristics. Results. After the Affordable Care Act (ACA), respondents in expansion states were significantly more likely to be employed compared with those in nonexpansion states (38.0% vs 31.9%; P = .011). Conclusions. Prior to the ACA, many people with disabilities were required to live in poverty to maintain their Medicaid eligibility. With Medicaid expansion, they can now enter the workforce, increase earnings, and maintain coverage. Public Health Implications. Medicaid expansion may improve employment for people with disabilities.
Incarceration Rates and Traits of Sexual Minorities in the United States: National Inmate Survey, 2011–2012
Authors: Meyer Ilan H. , Flores Andrew R. , Stemple Lara , Romero Adam P. , Wilson Bianca D. M. , Herman Jody L. 
Published: December 2016

Objectives. To report characteristics of sexual minority US inmates. Methods. We drew our data from the National Inmate Survey, 2011–2012, a probability sample of inmates in US prisons and jails. We determined weighted proportions and odds ratios with 95% confidence intervals to estimate differences between sexual minority and heterosexual inmates. Results. Sexual minorities (those who self-identify as lesbian, gay, or bisexual or report a same-sex sexual experience before arrival at the facility) were disproportionately incarcerated: 9.3% of men in prison, 6.2% of men in jail, 42.1% of women in prison, and 35.7% of women in jail were sexual minorities. The incarceration rate of self-identified lesbian, gay, or bisexual persons was 1882 per 100 000, more than 3 times that of the US adult population. Compared with straight inmates, sexual minorities were more likely to have been sexually victimized as children, to have been sexually victimized while incarcerated, to have experienced solitary confinement and other sanctions, and to report current psychological distress. Conclusions. There is disproportionate incarceration, mistreatment, harsh punishment, and sexual victimization of sexual minority inmates, which calls for special public policy and health interventions.
The effect of imipramine on the behavior of albino mice in presence of selenium
Authors: Aburawi S , Baayo S 
Published: December 2016

Abstract
Introduction: Imipramine, a tricyclic antidepressant used in the treatment of depression, anxiety, and other mental condition. Selenium is useful in managing depression and anxiety.
Aim: The present study was aimed to investigate the behavior effects of imipramine in presence of selenium on anxiety, spontaneous motor activity and antidepressant behavior.
Methods: Mice were divided into 5 groups of six each. Group 1 (control) was given 5ml/kg 1% Tween 80.Group 2 was given selenium (200 μg/kg). Group 3 was given diazepam (1 mg/kg).Group 4 mice was given imipramine (10 mg/kg).Group 5 was given combined treatment of selenium and imipramine. All drugs were injected as sub-acute (three doses), intraperitoneally and administered at 24, 5, and 1.0 hours before scoring. Animals were tested in the elevated plus maze, open field and forced swim test one hour after drugs injections. All drugs were given by intraperitoneal route.
Results: Imipramine in the dose used had no anxiolytic effect and no effect on motor activity. Selenium has anxiolytic effect in the plus maze and no effect on spontaneous motor activity. The anxiolytic effect of selenium disappeared when given with imipramine. Both imipramine and Selenium alone produced significant antidepressant effect in the forced swim test, this effect disappeared when selenium was administered with imipramine.
Conclusion: Both the anxiolytic effect of selenium and the antidepressant effect of imipramine and selenium was abolished when administered together.
A GLOBALIZAÇÃO, O DECLÍNIO DA SOBERANIA DO ESTADO E A CRISE ECONÔMICA DE 2007/2008: A NECESSIDADE DE CRIAÇÃO DE UM SISTEMA DE GOVERNANÇA ECONÔMICA GLOBAL
Authors: Bedin Gilmar Antonio , Brum Argemiro Luis , Cerdote Pedroso Márcia Nair 
Published: December 2016

<p><strong>Resumo</strong>:<strong> </strong>O presente artigo demonstra que há uma grande vinculação entre o fenômeno da globalização, o declínio da soberania dos Estados e a conformação da crise econômica de 2007/2008. Neste sentido, o texto destaca que a fragilização da soberania dos Estados fortaleceu os fluxos econômicos globais. Por isso, o artigo chama a atenção para a necessidade de criação de um sistema de governança econômica global e, em consequência, destaca a importância da fixação de regras e de procedimentos para a regulação do mercado e para tornar mais efetivos os controles dos fluxos econômicos globais. Na parte final, o texto defende que este sistema de governança econômica global se alicerce numa estrutura multilateral e represente os interesses dos Estados, das populações e dos mercados.</p><p><strong>Palavras-chave</strong>: Estado. Soberania. Globalização. Crise Econômica. Governança Global.</p><div><div><p> </p></div></div>
Unusual money
Authors: Bekbulatov Damir Ravilovich 
Published: December 2016

The article describes the energy as an integral part of our civilization, a harmonious development of society is impossible without it and you cannot feed, put on shoes and clothes, have anything warmed up and lit and delivered to the destination – hence the existence of the current number of the world's population is supported by produced energy. Authors considers that the sun is an inexhaustible source of energy, which is available in every country. Any country can now convert the sun light into electrical energy and get a single world currency.
Photodynamic therapy in the treatment of trophic venous ulcers
Authors: Nasyrov Marsel Vakifovich , Lukyianchikov Viktor Nikolaevich 
Published: December 2016

This article describes the analysis of results of treatment of 126 patients with trophic ulcers of the lower extremity venous etiology. Photodynamic therapy was used in the I group patients (n = 77). The standard treatment was performed in the II group (n = 49). The authors showed that the use of photodynamic therapy helped to reduce preoperative period 3 times and to make autodermaplasty of trophic ulcers in the I group on 5,2 ± 0,4 days. Full autodermotransplantata engraftment was observed in the I group in 75,4% of patients and in the II group – 46,8%. Photodynamic therapy has a strong antibacterial effect and improves the processes of epithelialization.
Discapacidad y su relación con variables sociodemográficas y clínicas en adultos de la ciudad de San Juan de Pasto, Nariño, Colombia.
Authors: Gil Obando Lida Martiza , López López Alexandra , Avila Rendón Carmen Liliana , Criollo Castro Carlos Hernando , Canchala Obando Alexandra Marcela , Serrato Medoza Maria Paula 
Published: December 2016

Introducción: La evaluación de discapacidad implica el análisis desde un nivel corporal, personal y social. Objetivo: Correlacionar discapacidad con variables sociodemográficas y clínicas de personas adultas de la ciudad de San Juan de Pasto, Colombia. Materiales y Métodos: Estudio correlacional, la muestra estuvo constituida por 117 personas con discapacidad, mayores de 20 años con más de seis meses de la limitación, se utilizó el WHODAS-II. Resultados: Las variables sociodemográficas edad, rangos de edad, estado civil y ocupación presentaron asociación significativa con movilidad y discapacidad final. Las variables clínicas de diagnóstico médico, tiempo y rangos de tiempo de limitación, tipo de ayuda externa, uso y tipo de medicamentos presentaron asociación significativa con las áreas de movilidad, autocuidado, relacionarse con otras personas, actividades de la vida diaria y participación en sociedad. Conclusión: Las personas con discapacidad del estudio en su mayoría fueron hombres, solteros, y con grado de discapacidad leve. La ocupación y las variables clínicas evidenciaron mayor repercusión sobre las actividades de la vida diaria, movilidad y discapacidad global.AbstractIntroduction: Disability evaluation involves analysis from a corporal, social and personal level. Objective: To correlate disability with sociodemographic and clinical variables of adults in San Juan de Pasto, Colombia. Materials and Method: A correlational study was made, whose sample consisted of 117 people with disabilities, who were older than 20 years old with more than six months with the disability. WHODAS II was used. Results: The sociodemographic variables: age, age ranges, marital status and occupation presented a significant association with mobility and final disability. The clinical variables: medical diagnosis, time and time ranges of disability, type of external help, use and type of drugs, showed a significant association with the areas of mobility, self-care, relationships with others, daily life activities and participation in society. Conclusions. People with disabilities in this study were mostly men, single and credited a degree of mild disability. Occupation and clinical variables showed greater impact on daily life activities, mobility and global disability.
Caracterización del dolor perineal postparto en puérperas
Authors: Medina Piedrahita Paula Andrea , Borrero Cortés Crystian , Herrera Gómez Pedro José , Ospina Díaz Juan Manuel 
Published: December 2016

Introducción: El dolor perineal posparto es un problema clínico frecuente, no abordado en profundidad en Colombia. Objetivo: Determinar la prevalencia, severidad y posibles factores asociados con el dolor perineal postparto en una muestra de mujeres en el Hospital La Victoria-Instituto Materno Infantil de Bogotá. Materiales y métodos: Estudio observacional prospectivo. Se evaluó el grado de dolor perineal percibido en 133 pacientes en posparto, mediante la escala análoga numérica de dolor, estando acostada, sentada, caminando y yendo al baño (micción y/o defecación), a las 12 y 48 horas postparto. Datos demográficos, del parto y recién nacido fueron tomados directamente de las historias clínicas. Resultados: Prevalencia global del dolor perineal moderado a severo 36-39,5% dependiendo de la actividad a las 12 horas del parto y entre 28-31,6% a las 48 horas. El dolor perineal se encontró asociado, en cualquiera de las actividades valoradas, con el uso de analgesia epidural durante el trabajo de parto, desgarro grado II o mayor, peso y perímetro cefálico del recién nacido. Se registra mejor efecto analgésico con dosis de acetaminofén de 3 g diarios o más. Conclusiones: El dolor perineal moderado a severo afecta a menos del 50% de las mujeres postparto vaginal; se asocia con la frecuencia y magnitud del trauma perineal. Los resultados sugieren la necesidad de profundizar en el estudio del manejo analgésico más adecuado para estas pacientes.Abstract Introduction: Postpartum perineum pain is a common clinical problem, which is not addressed in detail in Colombia. Objective: To assess prevalence, magnitude and possible factors associated with postpartum perineum pain in a sample of women in the Hospital “La Victoria-Instituto Materno Infantil”, in Bogotá. Materials and methods: A prospective observational study was performed where the degree of perineum pain perceived by 133 postpartum patients was evaluated by using numerical analog scale of pain when they were sitting down, lying, walking and going to the bathroom (urination and/or defecation), at 12 and 48 hours of postpartum . Demographic, birth and newborn data were taken directly from the medical records. Results: Overall prevalence of moderate to severe perineum pain 36 to 39.5% depending on the activity at 12 hours of delivery, and since 28 to 31.6% at 48 hours after it. Perineum pain was associated, during any of the activities assessed, with the use of epidural analgesia during labor, laceration of degree II or greater, birth weight and head circumference of the newborn. Better analgesic effect of acetaminophen doses as 3 g per day or more was registered. Conclusions: Moderate to severe perineum pain affects less than 50 % of women with vaginal postpartum. It is associated with the frequency and degree of perineum trauma. The results suggest the need for further study of the most appropriate analgesic doses for these patients.
Acuerdo intra-interobservador en las pruebas Minimental State Examination (MMSE) y Montreal Cognitive Assessment (MoCA test) aplicados por personal en entrenamiento
Authors: Pedraza Olga Lucía , Sierra Fabio , Salazar Ana María , Hernández Adriana Margarita , Ariza María José , Montalvo María Camila , Plata Juliana , Muñoz Yolanda , Díaz José Miguel , Piñeros César 
Published: December 2016

Introducción: en el proceso del diagnóstico neuropsicológico, los instrumentos de tamizaje cognitivo, son una herramienta útil en la identificación de cambios mentales del sujeto, en momentos puntuales o a través del tiempo. Su uso se fundamenta en el análisis psicométrico.
Objetivo: determinar el acuerdo inter e intra-observador en el MoCA test y el MMSE, aplicado por profesores y estudiantes en procesos de entrenamiento de tamización cognitiva.
Materiales y métodos: a los estudiantes y profesores en entrenamiento en la puntuación del MoCA test y el MMSE, se les presentó un video en dos sesiones, con un intervalo de 5 meses, mostrando el desempeño de dos adultos mayores, respondiendo el MoCA test y el MMSE, previo consentimiento informado. Se compararon los puntajes dados en las dos sesiones por los sujetos en entrenamiento, con los de ellos mismos (intra-observador), usando el coeficiente de concordancia y correlación de Lin(rho) y con los del grupo restante (inter-observador) usando el coeficiente de correlación intra-clase (ICC).
Resultados: participaron 46 evaluadores. Se encontró alta confiabilidad inter-observador para el MoCA (ICC=0.86), pero baja para el MMSE (ICC=0.24) y baja confiabilidad intra-observador tanto para el MoCA (rho paciente 1=0.012 y rho paciente 2=0.152) como para el MMSE (rho paciente 1=0.008 y rho paciente 2=0.012). Aunque los puntajes difirieron, las clasificaciones diagnósticas realizadas por los evaluadores fueron similares a las del patrón de oro.
Conclusión: la correcta aplicación del test, requiere varios entrenamientos, y aunque hubo pocas diferencias entre los puntajes, los errores cuando se está cerca del punto de corte propuesto, aumentan el riesgo de sesgo.
Gilles de la Tourette y su síndrome
Authors: Palacios Sánchez Leonardo , Vergara Méndez Laura Daniela , Martínez Camacho Arianna Valeria , Canal Piñeros Sebastián , Mora Muñoz Laura 
Published: December 2016

Georges Albert Brutus Edouard Gilles de la Tourette nació y se crio dentro de una época esplendorosa de Francia. Se destacó por sus méritos como estudiante y fue educado para que tuviera una brillante carrera como médico. Su paso por el hospital Pitie-Salpêtrière fue algo fundamental en su vida, ya que allí conoció al profesor Jean-Martin Charcot quien le brindó la oportunidad y las herramientas para estudiar su pasión, la Neurología, de una manera amplia la y dedicarse a otros casos interesantes dedicados a la mente humana.
Gracias a esto pudo describir la patología que hoy nos compete como el síndrome de La Tourette. Su estudio y su incansable curiosidad permitieron además involucrarse no sólo con este síndrome sino que ayudó a hacer múltiples descripciones de otras patologías e incursionó en el nuevo campo del hipnotismo. Sin embargo, su muerte prematura, debido a una enfermedad hoy en día curable, hizo que se truncara la maravillosa mente de este neurólogo que, muy seguramente, hubiese aportado más conocimiento de la época a nuestro saber actual.