bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Tapioca and Tragacanth based edible coatings on the physiological, chemical, microbial, and phytochemical quality of Tomato fruits
Authors: Fatima Haya , Ainee Ammara , Kausar Tusneem , Murtaza Mian Anjum , Hussain Ashiq , Raza Muhammad Siddique , Sidrah  , Bibi Barira , Ayesha Amina , Arif Muhammad Rehan , Zia Muhammad , Firdous Nida , Elkhedir Abdeen Elsiddig 
Published: October 2024

AbstractIn recent years, edible coatings have emerged as a promising solution to extend the shelf life, and maintain the quality of fruits and vegetables. The purpose of the study was the development and application of gum Tragacanth and Tapioca‐based edible coatings to extend the storability and quality of tomato (Solanum Lycopersicum L). Different treatments were prepared with combinations of Tragacanth gum (0.5, 1, 1.5 g) and Tapioca (1, 1.5, 2 g). Parameters such as weight loss, sugars, decay percentage, pH, titratable acidity, total soluble solids, antioxidant capacity, phenolic and flavonoid contents, microbial counts, and sensory evaluation were measured during 14 days storage. Results revealed that the application of gum Tragacanth and Tapioca‐based coatings significantly reduced weight loss, decay percentage, and microbial counts of treated tomatoes as compared to the control group. The coated tomatoes exhibited improved sensory features, with a slower rate of softening, during the storage. There was a significant increment in total phenolic and flavonoid contents and antioxidant capacity of coated fruits during 7 days of storage. The observed improvements in the postharvest quality attributes suggest that the gum Tragacanth and Tapioca‐based edible coatings have the potential to retain and enhance the nutritional and bioactive contents and shelf life of tomato.
Strategic Energy Management in Fuel Cell Electric Vehicles: A Prognostic Perspective on Dual Energy Source Degradation
Authors: Sun Nannan , Li Xintong , Xi Fuqiang , Shen Xuesong , Cheng Xiaoxian , Liu Haitao , Zhang Jing , Meng Jianwen , Yue Meiling 
Published: October 2024

ABSTRACTFuel cell technology is a promising alternative to traditional internal combustion engines in various applications, especially in transportation applications. This paper proposes a framework of strategic energy management for fuel cell electric vehicles (FCEVs), which is developed to safeguard the dual vehicle energy sources, that is, fuel cells and power batteries. This is accomplished by applying an energy management strategy (EMS) from a prognostic perspective. A fuzzy energy management approach is used to manage the power flow in the FCEV, enabling safe and predefined operation at multiple degradation points. To guarantee reliable and continuous energy source functioning, prognostics algorithms are incorporated into the EMS to identify energy source degradation. The prediction results are integrated into the controller by refining the controller parameters geometrically. Simulation outcomes show that the proposed EMS offers efficient use the dual energy sources, which improves the durability of the energy sources.
Aminated ZIF‐8 to facilitate CO2 sieving through polyvinyl alcohol/ionic liquid membranes
Authors: Hong Chia‐Huey , Leo Choe Peng , Ahmad Nor Naimah Rosyadah , Ahmad Abul Latif 
Published: October 2024

AbstractCO2 separation technology at low pressure is most desirable in carbon capture projects to mitigate global warming. Facilitated transport membranes offer selective and effective CO2 permeation using a wide range of carbon carriers at low pressure. Porous fillers were recently included as they can carry abundant fixed carriers besides offering open channels for CO2 permeation. This study investigates the effects of amine‐modified zeolitic imidazolate framework‐8 (ZIF‐8) with well‐defined micropores and gas sieving ability in polyvinyl alcohol (PVA) membranes containing an ionic liquid that worked as mobile carriers. The effects of amine‐modified ZIF‐8 and silica nanoparticles on membrane properties and separation performance were also compared. Fourier transform infrared spectra confirmed the incorporation of ZIF‐8, secondary amine, IL anions, and silica nanoparticles in PVA membranes. Energy dispersive analysis showed the good dispersion of inorganic fillers. The amine‐modified silica nanoparticles resulted in higher thermal stability compared to the amine‐modified ZIF‐8 in PVA membranes containing [bmin][Ac] ionic liquid, as shown in the thermogravimetric analysis. However, the CO2 separation performance of PVA membranes containing [bmim][Ac] ionic liquid was improved more significantly by the amine‐modified ZIF‐8 with microporous structure. A CO2/N2 ideal selectivity of 85.65 and CO2 permeance up to 4,502.91 GPU were attained. Unlike the CO2/N2 ideal selectivity, the CO2 permeance was not significantly affected either using [bmin][Ac] or [bmin][BF4]. The humid gas greatly enhanced the CO2 permeance without much changes in the CO2/N2 ideal selectivity due to the promotion of facilitated transport. © 2024 Society of Chemical Industry and John Wiley & Sons, Ltd.
The Mediating Effect of Physical Performance on Physical Activity and Mild Cognitive Impairment Among Older Adults With Type 2 Diabetes in Rural China
Authors: Liu Xueyan , Cao Yingjuan 
Published: October 2024

ABSTRACTObjectivesTo investigate the intermediary role of physical performance in the association between physical activity and mild cognitive impairment (MCI) in older adults with type 2 diabetes mellitus (T2DM), residing in rural areas.MethodsThis study employed a random sampling method to select 316 patients aged 65 years and older, all diagnosed with T2DM, from 24 different rural areas in China. The relationships between physical activity, physical performance, and MCI were analyzed using a logistic regression model, and the proposed mediation model was validated through bootstrap test.ResultsIn this study, the prevalence of MCI in the rural‐based older adults with T2DM was 53.48%. A significant correlation was observed between the levels of physical activity and physical performance. Moreover, diminished physical performance was positively correlated with an increased propensity for MCI, even after adjusting for relevant covariates. Physical performance was discerned to exert a partial mediating influence on the relationship between physical activity and MCI.ConclusionsThe empirical evidence generated by this study posits that the impact of physical activity on MCI is partially mediated through physical performance in an aging population with T2DM residing in rural environments. Consequently, interventional strategies aimed at ameliorating physical performance may serve as a viable approach to mitigate the progression of cognitive decline.
Pain Catastrophizing and Functional Activation During Occlusion in TMD Patients—An Interventional Study
Authors: Klepzig K. , Domin M. , Kordass B. , Lotze M. 
Published: October 2024

ABSTRACTIn temporomandibular disorder (TMD), the effects of standard interventions such as using an occlusal splint and its impact on pain relief and pain catastrophizing are poorly understood. Earlier work pointed to a crucial role of insula activation with changes in pain relief by occlusal splint treatment. We performed a functional imaging study using specially developed splint systems to allow for a placebo‐controlled longitudinal design. Using functional MRI we examined 20 TMD patients during repetitive occlusal movements at baseline and over the course of splint therapy and also collected self‐reported pain catastrophizing. For balancing performance between baseline and after intervention we used occlusion force measures in an individualized fMRI‐splint system. Splint therapy lasted for approximately 7 weeks with one group selected by randomization wearing a palatine placebo splint over the first 3 weeks (delayed start; 11 individuals). As expected, fMRI activation in areas involved in pain processing (insula, primary and secondary somatosensory cortex) decreased with intervention. At baseline a positive correlation between activation of the left anterior insula and pain catastrophizing was present. Both parameters decreased over intervention while associations were primarily observable for patients with rather mild TMD.
The purpose of directors' duties in the insolvency context: A critical assessment based on empirical data from Austria and Netherlands
Authors: Pool Jessie , Wabl Georg 
Published: October 2024

AbstractThis paper examines the evolving discussions on directors’ duties in the insolvency context within the EU, particularly in light of recent harmonisation initiatives such as the 2019 Directive on Restructuring and Insolvency and the 2022 Proposal mandating a duty to file for insolvency. Using empirical data from Austria—a jurisdiction with a duty to file—and the Netherlands, which lacks this duty, the study investigates the potential impact and practicality of such requirements. Findings reveal that while Austria and the Netherlands have different frameworks, similar issues in enforcement and compliance emerge in both. These results suggest that imposing stricter or more explicit norms on directors across the EU may not effectively achieve policy goals, especially if financial constraints on enforcement remain unaddressed. We advocate for a policy approach that focuses on practical outcomes and enforcement capacity.
Maternal serum Numb in the first trimester of pregnancy as a biomarker for early prediction of pre‐eclampsia: A prospective cohort study
Authors: Jiang Ying , Chen Xiaofeng , Li Shaoxing , Huang Chaolin , Cheng Xuehua 
Published: October 2024

AbstractObjectiveEarly identification of women at risk of developing pre‐eclampsia is beneficial as it allows for timely intervention strategies. This study aimed to evaluate the potential of serum Numb in the first trimester as a biomarker for early prediction of pre‐eclampsia.MethodsThis prospective observational cohort study was carried out at a tertiary teaching hospital between January 2021 and December 2022. A total of 1024 women were recruited during their 8–13 weeks of pregnancy and were followed up until delivery. Serum Numb levels were measured during 8–13 weeks of gestation for all participants. At the same time, the participants' anthropometric, clinical, and laboratory data were collected. A logistic regression model was used to investigate the potential association between serum Numb levels and the risk of pre‐eclampsia. Receiver operating characteristic curves (ROCs) and area under the curves (AUCs) were utilized to evaluate the predictive efficacy of serum Numb levels for pre‐eclampsia in the first trimester.ResultsSerum Numb levels were found to be significantly higher in pregnant women who developed pre‐eclampsia compared to those who did not develop pre‐eclampsia. Increased serum Numb levels were identified as an independent risk factor for pre‐eclampsia, with an odds ratio (OR) of 3.27 (95% CI: 2.05–4.53) for the risk of pre‐eclampsia. Numb levels showed a significant positive correlation with the risk of pre‐eclampsia. Furthermore, Numb levels demonstrated a strong predictive efficacy for pre‐eclampsia in the first trimester of pregnancy, with an AUC value of 0.86, a cutoff value of 48.73 ng/mL, a sensitivity of 79.24%, and a specificity of 75.73%.ConclusionSerum Numb in the first trimester of pregnancy can serve as a biomarker for the early prediction of pre‐eclampsia. This provides a valuable approach in clinical practice to identify pregnant women in the first trimester of pregnancy, who are at a higher risk of developing pre‐eclampsia.
SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer
Authors: Yildiz Baris , Demirel Ramazan , Staudacher Jonas J. , Beseren Hatice , Yildiz Gulden , Akpinar Ali Emre , Park Seong‐Hoon , Ozden Ozkan 
Published: October 2024

AbstractNew FOXM1‐specific inhibitors with the potential to be used for therapeutic purposes are under extensive research. We hypothesized that deacetylation of FOXM1 would decrease protein expression, thus providing novel therapeutic management of colon cancers. Immunostaining was used to determine FOXM1 and SIRT2 expressions in human colon cancer tissue microarrays (n = 90) from Stage I to Stage IV. SIRT2‐FOXM1 interaction was evaluated in colon cancer cells using immunoprecipitation. Deacetylation of FOXM1 via SIRT2 was determined using in vitro deacetylation assays. FOXM1 could be hyper‐acetylated when p300 and pCAF histone acetyltransferases were administered alongside deacetylase inhibitors. We detected that SIRT2 and FOXM1 physically interacted, and SIRT2 deacetylated FOXM1 in vitro. SIRT2 overexpression led to a significant decrease while knockdown of SIRT2 increased the FOXM1 expression in HCT116 human colon carcinoma cells. In the analysis of 90 human colorectal cancer samples, high SIRT2 expression was observed in about 49% of colorectal cancer, intermediate in 29%, and low or no staining in 22%. Strong SIRT2 expression was found to be negatively associated with the FOXM1 staining in our clinical cohort. This study reveals a molecular interaction and association between SIRT2 and FOXM1 expression in colon cancer cell lines and human colon cancer samples, and suggests that targeting SIRT2 activity using small molecule modulators may be a promising therapeutic approach for colorectal cancer.
An evaluation of a virtual musculoskeletal podiatry service implemented to address prolonged National Health Service waiting times
Authors: Brunilda Agalliu , Thanaporn Tunprasert , Tom Walton , Liam McManus 
Published: October 2024

AbstractBackgroundThe COVID‐19 pandemic had a substantial impact on healthcare systems globally, particularly in the public sector. To address the challenges posed by the pandemic, musculoskeletal (MSK) healthcare providers had to rapidly adopt virtual platforms for delivering care, representing a major shift in how healthcare was delivered.ObjectiveThis manuscript aims to retrospectively evaluate a virtual MSK podiatry service offered by a private provider under a National Health Service commission, in terms of patient access, waiting times and patient‐reported pain. This service was developed and implemented in response to the COVID‐19 pandemic and the extended waiting times.MethodsA retrospective clinical service evaluation was conducted on MSK podiatry services delivered via telephone or virtual consultations. The evaluation covered a cohort of 574 referred patients over a 19‐month period (July 2021 to January 2023). It analysed demographic data, initial and final visual analogue pain scores, pathology categories, orthoses prescriptions and exercise rehabilitation plans.ResultsData from a total of 492 patients (male = 152 and female = 340) were analysed, with 82 patients excluded for non‐attendance. The average waiting time from referral‐to‐first appointment and referral‐to‐discharge was 35 and 91 days, respectively. Results showed statistically significant improvement (p < 0.001) in the mean visual analogue scale when patients received orthoses with and without a rehabilitation plan (4.12 ± 2.55 and 3.33 ± 2.88, respectively). Most patients (61.5%) were aged 40–69, with “foot pain” being the main reported pathology category. Patients had an average of two appointments. 56.5% of patients remained virtual throughout their journey and were successfully discharged to self‐management. 43.9% were discharged to other face‐to face services.ConclusionsThe study provided evidence that the virtual MSK podiatry service achieved a statistically significant reduction in patient‐reported pain for various pathologies with reasonable waiting times. The service delivered favourable outcomes and complemented traditional services at a time with limited access due to the COVID‐19 pandemic.
Contested role boundaries and professional title: Implications of the independent review of podiatric surgery in Australia
Authors: Borthwick Alan M. , Nancarrow Susan , Bristow Ivan , Bowen Catherine 
Published: October 2024

AbstractIntroductionIn October 2023, the Podiatry Board of Australia commissioned an independent review of the regulation of podiatric surgery in Australia, with a remit to re‐evaluate the regulatory framework, identify any risks to patient safety and recommend improvements to public protection. It reported in March 2024 and set out 14 key recommendations. The review was prompted by a number of complaints about podiatric surgeons but also reflected calls for reform by the medical profession and several critical media reports. This paper sets out to examine the review report, alongside the concerns of the medical profession and the media articles expressed within it, through the lens of an established sociological framework focused on interprofessional conflict and the contested use of professional titles.MethodsAs a review rather than the research paper, the Independent Review of Podiatric Surgery (the ‘Paterson Report’) served as data for the sociological analysis, adopting a Neo‐Weberian and Bordieuan framework to examine the strategies adopted by the medical profession and media reports cited in the report, consistent with the exercise of professional power.ResultsThe sociological analysis provides insights into the ways in which professions seek to maintain symbolic, social, cultural and economic privileges and rewards through the exclusion of competitors, using strategies such as social closure, symbolic violence, symbolic devaluation, gatekeeper roles, and jurisdictional disputes.ConclusionsThe review report acknowledges the influence of the medical profession and its opposition to the practice of podiatric surgery and use of the title ‘podiatric surgeon’. The arguments made and strategies deployed are consistent with those found in the wider literature. In light of these findings, the implications for the future of podiatric surgery are considered in terms of professional practice, use of professional title, and access to public funding.
An overview of the risk factors for producing fifth metatarsal fracture in sports activities: A systematic review
Authors: Ortiz‐Lango Luis Angel , Miguel‐Andrés Israel , López‐López Daniel , Mayagoitiza‐Vázquez José de Jesús , Becerro‐de‐Bengoa‐Vallejo Ricardo , Losa‐Iglesias Marta , Gómez‐Salgado Juan , Saavedra‐García Miguel Ángel 
Published: October 2024

AbstractIntroductionThe fifth metatarsal fracture is a foot injury that occurs in sports activities. This fracture has been associated with risk factors based on intrinsic variables such as type of feet (flatfoot or cavus foot), foot pathologies, and bone density among others. Extrinsic variables associated with fifth metatarsal fractures include sports maneuvers, the type of sports practice, and contact surface. Although this injury has been investigated over the years, there is no consensus on the most relevant risk factors that cause this injury. An increase in the number of people with fractures makes it a relevant topic of research. The objective of this review was to identify an overview of the risk factors for producing the fifth metatarsal fracture based on intrinsic and extrinsic variables in sports activities. Furthermore, this review aimed to clarify what is known and what is needed on the risk factors that can influence the appearance of the fracture.MethodsA search in electronic databases, such as Scopus (n = 87), PubMed (n = 187), and Web of Science (n = 173) was conducted. The initial search yielded 447 titles and abstracts, from which 31 papers were selected for detailed analysis after screening all citations against the eligibility criteria.ResultsAfter screening the manuscripts, it was found that the fifth metatarsal fracture can be produced by multiple factors. However, most of the studies focus on one or two specific risk factors. It was found that soccer (38.7%) is the sports activity that presents a higher risk of getting a fifth metatarsal fracture compared to other sports activities. The second risk factor was the performance of critical maneuvers (22.5%) and the third one was the biomechanics of the foot (22.5%).ConclusionIt is paramount to identify the most critical risk factors linked to the fifth metatarsal fracture to be able to implement effective treatments and prevention strategies.
3D‐printed custom ankle braces for people with Charcot‐Marie‐Tooth disease: A pilot study
Authors: Philps Adam , Frecklington Mike , Stewart Sarah 
Published: October 2024

AbstractIntroductionCharcot‐Marie‐Tooth disease (CMT) is a neurodegenerative condition resulting in footdrop, ankle instability and impaired balance and gait. This study aimed to determine (1) whether 3D‐printed custom ankle braces improve function and balance in people with CMT and (2) whether this is an acceptable device for use in this population.MethodsA within‐subject comparison pragmatic/pilot study was undertaken. Ten people with CMT (mean [SD] age 48 [14] years, 60% male) were fitted with 3D‐printed ankle braces. Following a 4‐week wear‐in period, walking and balance tests and patient‐reported outcomes were assessed in two experimental conditions: (i) usual shoes and (ii) usual shoes with 3D‐printed custom ankle braces. Differences in outcome measures between experimental conditions were analysed using linear mixed models. Comfort, aesthetics and overall satisfaction of the brace were assessed via 100‐mm visual analogue scale (VAS). Adverse events and tripping/falls associated with the brace during the wear‐in period were also recorded by participants using daily diaries.ResultsA significant improvement was seen during single‐leg balance with eyes open (p = 0.026, Cohen's d = 0.55) and a significant reduction in foot pain (p = 0.045, Cohen's d = 0.82), with use of the ankle brace. Mean (SD) 100 mm VAS scores were 62.7 mm (17.9) for overall comfort and 73.9 mm (21.2) for overall satisfaction. Subjective data from the daily dairies showed that one participant found the brace too firm around the ankle due to loss of soft tissue mass and two participants found it challenging to don and doff the brace due to loss of hand dexterity.ConclusionThis pilot study suggests that a 3D‐printed custom ankle brace may improve balance and reduce foot pain in people with CMT; however, larger‐scale trials are needed to further explore the impact of this brace on function and balance. Further customisation of the brace may also be required to improve acceptability for some people.
Hyperostosis in Fishes: An Update With New Species Records
Authors: Smith‐Vaniz William F. , Klein Julia , Ahnelt Harald 
Published: October 2024

ABSTRACTLiterature reports of hyperostosis are often misleading and have been confused with osteomas, a pathological condition. Hyperostotic bones are known to occur only in bony fishes of the class Actinopterygii, within at least 16 orders, 35 families, 89 genera, and 153 species. They are present almost exclusively in marine fishes and exceptionally in a few extinct freshwater species known from hypersaline environments and one extant cichlid. Hyperostosis is best represented in the family Carangidae where it is known to occur in 53 of approximately 181 valid species. We also provide a synthetic report on what we know and what misconceptions exist regarding hyperostosis. Patterns of hyperostosis are often species‐specific but provide no useful phylogenetic information. In species known to develop hyperostosis, it is usually not apparent (non‐histologically) in juveniles and typically only becomes fully developed in the largest individuals. The timing of hyperostosis on‐set in different bones is often sequential rather than simultaneous across different bones. Most marine Neoteleostei have acellular skeletons but histological observations have shown that in species exhibiting hyperostosis, areas of active remodeling are composed primarily of cellular bone characterized by a rich vascular network and bone‐resorbing osteoclasts.