bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethnic Diversity and Distinctive Features of Familial Versus Multifactorial Chylomicronemia Syndrome: Insights From the UK FCS National Registry
Authors: Bashir Bilal , Downie Paul , Forrester Natalie , Wierzbicki Anthony S. , Dawson Charlotte , Jones Alan , Jenkinson Fiona , Mansfield Michael , Datta Dev , Delaney Hannah , Teoh Yee , Hamilton Paul , Ferdousi Maryam , Kwok See , O’Sullivan Dawn , Wang Jian , Hegele Robert A. , Durrington Paul N. , Soran Handrean 
Published: September 2024

BACKGROUND:
Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder. This study aimed to study the genotype distribution of FCS-causing genes in the United Kingdom, genotype-phenotype correlation, and clinical differences between FCS and multifactorial chylomicronemia syndrome (MCS).

METHODS:
The study included 154 patients (FCS, 74; MCS, 80) from the UK FCS national registry and the UK arm of the FCS International Quality Improvement and Service Evaluation Project.

RESULTS:

FCS was relatively common in non-Europeans and those with parental consanguinity (
P
<0.001 for both).
LPL
variants were more common in European patients with FCS (European, 64%; non-European, 46%), while the genotype was more diverse in non-European patients with FCS. Patients with FCS had a higher incidence compared with patients with MCS of acute pancreatitis (84% versus 60%;
P
=0.001), recurrent pancreatitis (92% versus 63%;
P
<0.001), unexplained abdominal pain (84% versus 52%;
P
<0.001), earlier age of onset (median [interquartile range]) of symptoms (15.0 [5.5–26.5] versus 34.0 [25.2–41.7] years;
P
<0.001), and of acute pancreatitis (24.0 [10.7–31.0] versus 33.5 [26.0–42.5] years;
P
<0.001). Adverse cardiometabolic features and their co-occurrence was more common in individuals with MCS compared with those with FCS (
P
<0.001 for each). Atherosclerotic cardiovascular disease was more prevalent in individuals with MCS than those with FCS (
P
=0.04). However, this association became nonsignificant after adjusting for age, sex, and body mass index. The prevalence of pancreatic complications and cardiometabolic profile of variant-positive MCS was intermediate between FCS and variant-negative MCS.

CONCLUSIONS:
The frequency of gene variant distribution varies based on the ethnic origin of patients with FCS. Patients with FCS are at a higher risk of pancreatic complications while the prevalence of atherosclerotic cardiovascular disease is lower in FCS compared with MCS. Carriers of heterozygous pathogenic variants have an intermediate phenotype between FCS and variant-negative MCS.
Identifying Trends in Admission and Release of Wild Koalas in Veterinary Clinics Throughout Queensland, Australia
Authors: Charalambous Renae , Descovich Kris A. , Narayan Edward J. 
Published: September 2024

Abstract
Populations of Queensland koalas are rapidly declining, and the driving force behind this is habitat loss. This study analyzed reports (N = 50,858) made to three wildlife- focused veterinary clinics within the South-East Queensland Wildlife Hospital Network for assistance relating to a sick or injured wild koala between 1997 and 2019. Using descriptive and inferential statistics, a nominal logistic regression was performed to test the effect of key independent variables (age, sex, and etiology) on the outcome of each koala (released, deceased, euthanized) after being reported. Results found that the most common outcome for both sexes, most etiologies, and all ages was euthanasia. A comprehensive understanding of the primary risks affecting endangered species, and how these risks affect the likelihood of survival, is essential to inform species conservation policies and extinction risk assessments. We hope this study can provide an indispensable basis for future koala conservation strategies.
A Memorial Day for the Books Annihilated in the Holocaust: History and Reason
Authors: Hershkowitz Isaac 
Published: September 2024

Abstract
This article focuses on a Memorial Day ceremony that was regularly held during the State of Israel’s first two decades to honor the holy books destroyed during the Holocaust. The ceremony aimed to commemorate the Nazis’ attempt to destroy Judaism, not just the Jewish people. At the forefront of these efforts was Shmuel Zanwil Kahana, who sought to create a mystical atmosphere during the ceremony. His goal was to approach the new altar, represented by the furnace at Mount Zion, and offer a sacrifice of exilic literature to arouse a new spirit within the people of Israel. Despite his almost occult practices and liturgy, Kahana did not achieve the results for which he hoped. His attempts to build the nation through the destruction of its exilic spirit did not succeed.
Fr. Cyprian (Kern, 1899–1960), His Diaries and Memoirs
Authors: Zanemonets Alexander 
Published: September 2024

Abstract
The article is devoted to Fr. Cyprian (Kern, 1899–1960), evaluating his Diaries and Memoirs, edited in 2021 by the author. One of the eminent theologians of the Russian Emigration, professor of Saint Sergius Theological Institute in Paris, Fr. Cyprian was born and brought up in Russia, took part in the Russian Civil war, and lived as a young Russian emigrant in Yugoslavia in 1920–1930. In 1928–1930 he was the Head of the Russian Ecclesiastical Mission in Jerusalem.
His Memoirs and Jerusalem Diaries are a very important and in fact unique source not only for the biography of Fr. Cyprian himself, but for the religious and cultural life of the Russian Emigration in the Balkans and in the Holy Land during the first half of the 20th century. They also shed light on characteristic patterns concerning the interaction between different communities in those regions.
Memory and Environment
Authors: Gülüm Erol , Leworthy Paul , Tabaszewska Justyna , Teichler Hanna 
Published: September 2024

Abstract
The story of memory studies has been told as a tale of booms and waves. Most recently, a fourth wave of memory studies, responding to the environmental, ecocritical and post-humanist turn in the humanities, has been heralded (Craps et al., 2018). This Special Issue aims to trace and reflect upon the developments that have led to this fourth phase. At the outset, however, it needs to be acknowledged that we consider how memory and different forms of environment have long been understood as interrelated. Firstly, environments have featured as metaphors to focus attention on contexts of different kinds that are pertinent to acts of remembering. Secondly, environments have been considered as the background settings for memory processes: the places in which memory work is done. Thirdly, environments have been considered a functional parts of memory processes – where an environment serves as a media carrier of memory content that is actively involved in the transmission process. Although we chart how significant recent shifts in dominant modes of defining the term “environment” have impacted the field of memory studies and contributed to developments that have been construed as a fourth wave of memory studies, we argue that such a the fourth wave of memory studies does not represent a paradigmatic shift in our understanding of the relationship between memory and environment, but rather a shift in emphasis. As we move from memory place to mnemonic space to planetary memory (Bond et al., 2017; Chakrabarty & Latour, 2021; Crownshaw, 2014), the most significant shifts in our understanding of memory pertain to epistemology, category and scale. These altered frames of perception invite us to understand memory and environment as embedded, co-constitutive and co-constructed. Whilst there has been a consensus within the field of memory studies that only humans have the ability to “remember in ways that link individual remembering to cultural frameworks” (Kansteiner, 2002), a stronger emphasis on exploring the role of non-human entities in memory processes stands to challenge this conviction.
Dust, Convection, Winds, and Waves: The 2022 NASA CPEX-CV Campaign
Authors: Nowottnick Edward P. , Rowe Angela K. , Nehrir Amin R. , Zawislak Jonathan A. , Piña Aaron J. , McCarty Will , Barton-Grimley Rory A. , Bedka Kristopher M. , Bennett J. Ryan , Brammer Alan , Buzanowicz Megan E. , Chen Gao , Chen Shu-Hua , Chen Shuyi S. , Colarco Peter R. , Cooney John W. , Crosbie Ewan , Doyle James , Fehr Thorsten , Ferrare Richard A. , Harrah Steven D. , Hristova-Veleva Svetla M. , Lambrigtsen Bjorn H. , Lawton Quinton A. , Lee Allan , Marinou Eleni , Martin Elinor R. , Močnik Griša , Mazza Edoardo , Rodriguez Monje Raquel , Núñez Ocasio Kelly M. , Pu Zhaoxia , Rajagopal Manikandan , Reid Jeffrey S. , Robinson Claire E. , Rios-Berrios Rosimar , Rodenkirch Benjamin D. , Sakaeda Naoko , Salazar Vidal , Shook Michael A. , Sinclair Leigh , Skofronick-Jackson Gail M. , Thornhill K. Lee , Torn Ryan D. , Van Gilst David P. , Veals Peter G. , Vömel Holger , Wong Sun , Wu Shun-Nan , Ziemba Luke D. , Zipser Edward J. 
Published: September 2024

Abstract
The NASA Convective Processes Experiment-Cabo Verde (CPEX-CV) field campaign took place in September 2022 out of Sal Island, Cabo Verde. A unique payload aboard the NASA DC-8 aircraft equipped with advanced remote sensing and in situ instrumentation, in conjunction with radiosonde launches and satellite observations, allowed CPEX-CV to target the coupling between atmospheric dynamics, marine boundary layer properties, convection, and the dust-laden Saharan air layer in the data-sparse tropical East Atlantic region. CPEX-CV provided measurements of African easterly wave environments, diurnal cycle impacts on convective life cycle, and several Saharan dust outbreaks, including the highest dust optical depth observed by the DC-8 interacting with what would become Tropical Storm Hermine. Preliminary results from CPEX-CV underscore the positive impact of dedicated tropical East Atlantic observations on downstream forecast skill, including sampling environmental forcings impacting the development of several nondeveloping and developing convective systems such as Hurricanes Fiona and Ian. Combined airborne radar, lidar, and radiometer measurements uniquely provide near-storm environments associated with convection on various spatiotemporal scales and, with in situ observations, insights into controls on Saharan dust properties with transport. The DC-8 also collaborated with the European Space Agency to perform coordinated validation flights under the Aeolus spaceborne wind lidar and over the Mindelo ground site, highlighting the enhanced sampling potential through partnership opportunities. CPEX-CV engaged in professional development through dedicated team-building exercises that equipped the team with a cohesive approach for targeting CPEX-CV science objectives and promoted active participation of scientists across all career stages.
Assessing Farm Income and Input Efficiency Under Zero-budget Natural Farming in India
Authors: Mishra Brajaraja 
Published: September 2024

As against using chemical fertilisers and associated inputs, Indian farmers have been adopting various agroecological practices under Zero-budget Natural Farming (ZBNF) programme, which are locally sourced at zero/low costs, thus making cultivation economical and sustainable. This article aims to analyse its impact on production costs, farm income and input efficiency vis-à-vis farmers following chemical farming. Based on the political agroecology framework, household survey data and statistical and stochastic frontier production function, it explores the support of the government and local level stakeholders in promoting ZBNF, various agroecological practices followed by the farmers, and how these are related to production costs, farm income and input farm efficiency. It found comparatively low costs, higher farm income and better input efficiency than farmers practicing chemical farming which are statistically significant. Region-specific heterogeneities concerning such differences are very well observed. It suggests optimising the programme’s benefits by addressing constraints faced by the ZBNF farmers and scaling up the programme to other parts of the region. JEL Codes: O13, Q12, R11, R52
Suicidal behaviors among high school graduates with preexisting mental health problems: A machine learning and GIS-based study
Authors: Al-Mamun Firoj , Hasan Md Emran , Roy Nitai , ALmerab Moneerah Mohammad , Mamun Mohammed A 
Published: September 2024

Background: Suicidal behavior among adolescents with mental health disorders, such as depression and anxiety, is a critical issue. This study explores the prevalence and predictors of past-year suicidal behaviors among Bangladeshi high school graduates, employing both traditional statistical and machine learning methods. Aims: To investigate the prevalence and predictors of past-year suicidal behaviors among high school graduates with mental health disorders, evaluate the effectiveness of various machine learning models in predicting these behaviors, and identify geographical disparities. Methods: A cross-sectional survey was conducted with 1,242 high school graduates (54.1% female) in June 2023, collecting data on sociodemographic characteristics, mental health status, sleep patterns, and digital addiction. Statistical analyses were performed using SPSS, while machine learning and GIS analyses were conducted with Python and ArcMap 10.8, respectively. Results: Among the participants, 29.9% reported suicidal ideation, 15.3% had suicide plans, and 5.4% attempted suicide in the past year. Significant predictors included rural residence, sleep duration, comorbid depression and anxiety, and digital addiction. Machine learning analyses revealed that permanent residence was the most significant predictor of suicidal behavior, while digital addiction had the least impact. Among the models used, the CatBoost model achieved the highest accuracy (69.42% for ideation, 87.05% for planning, and 94.77% for attempts) and demonstrated superior predictive performance. Geographical analysis showed higher rates of suicidal behaviors in specific districts, though overall disparities were not statistically significant. Conclusion: Enhancing mental health services in rural areas, addressing sleep issues, and implementing digital health and community awareness programs are crucial for reducing suicidal behavior. Future longitudinal research is needed to better understand these factors and develop more effective prevention strategies.
Efficacy and outcomes of a highland prehospital trauma response team
Authors: Burgess Reuben , Mallinson Tom , Regan Luke 
Published: September 2024

Background and aims The Scottish Highlands face unique prehospital care challenges due to population dispersity, mountainous terrain, seasonal weather, and higher trauma burden compared to the nearest Major Trauma Centres (MTCs) as highlighted by the Scottish Trauma Audit Group (STAG). Primary road/air transfer from scene to nearest designated MTC averages 1–5 hours, making prompt and informed utilisation of prehospital and in-hospital resources within the Highlands critical – comparative to other UK metropolitan regions where the trauma population majority lay within 20–45 minute transfer windows. This paper reviews the Highland pre-hospital immediate care and trauma (PICT) Team's trauma response through a retrospective review of PICT patient report forms (PRFs). Methods and results The analysis highlighted increased trauma response by the team in the nature of attended callouts and interventions utilised. Improving trends of patient outcomes, increased advanced analgesia and medico-surgical intervention utilisation, and relative increase of road traffic collision attendance and trauma-specific calls were noted Conclusion Results highlight the Scottish Highlands’ trauma burden and PICT's added value; with increased trauma response and improving outcomes. Despite the rate and ratio of major trauma not reducing PICT Team utilisation has, potentially led to fewer patients over narrower geography at later stages in emergency calls accessing the enhanced care doctor and advanced physician team than was achieved previously.
Alteration of lncRNA RHPN1-AS1 predicts clinical prognosis and regulates the progression of bladder cancer via modulating miR-485-5p
Authors: Zhou Jingmin , Xu Jinshan , Cheng Lin , Li Shuhui , Jiang Deqi , Zhang Jianchao , Sheng Yulong 
Published: September 2024

Background Exploring effect biomarkers that monitor tumor progression and predict the prognosis could benefit the clinical management of bladder cancer and improve the postoperative life of patients. This study aimed to estimate the function of long non-coding (lnc)RNA RHPN1-AS1 (RHPN1-AS1) in bladder cancer and the potential molecular mechanism. Methods The expression of RHPN1-AS1 was evaluated in bladder cancer tissues from 115 patients and cells by polymerase chain reaction. The clinical significance of RHPN1-AS1 was assessed and its effect was also estimated in cell proliferation, migration, and invasion. The underlying molecular mechanism was explored by the dual-luciferase reporter assay. Results The expression of RHPN1-AS1 was 2.91-fold elevated in bladder cancer, which showed a close correlation with advanced tumor node metastasis stage ( P = 0.013) and the presence of lymph node metastasis ( P = 0.018). RHPN1-AS1 also served as a poor prognostic indicator (hazard ratio = 2.563) for bladder cancer. The knockdown of RHPN1-AS1 significantly suppressed the proliferation and metastasis ability of bladder cancer cells. Moreover, miR-485-5p was found to mediate the function of RHPN1-AS1 in bladder cancer, which was considered the underlying regulatory mechanism. Conclusions RHPN1-AS1 serves as a prognostic biomarker and tumor promoter in bladder cancer via modulating miR-485-5p, which might be a reliable target of bladder cancer therapy.
Blockades in the Pathway of Specialty Care in Sjogren’s and Systemic Sclerosis: A Report Based on Indian Rheumatology Association Database
Authors: Chandrashekara S  , Shenoy Padmanabha , Kumar Uma , Pandya Sapan , Ghosh Alakendu , Khare Apurva , Dudam Rajkiran , Danda Debashish , Goswami Rudra Prosad 
Published: September 2024

Aim: The present study aimed to evaluate the factors influencing the referral delay in patients with primary Sjogren’s syndrome (Sjogren’s) and systemic sclerosis (SSc). Materials and Methods: The independent, multicentre, cross-sectional study collected data from seven centres across India through the Indian Rheumatology Association (IRA) database. The patient-related factors and referral factors were determined based on the patient narrations. Based on the patient’s income, a modified version of the Prasad scale was employed to classify them according to socioeconomic status. Results: The study included 118 patients with Sjogren’s and 166 patients with SSc. Approximately 60% of patients with SSc and Sjogren’s received rheumatology specialty care more than 6 months after symptom onset. The primary reasons for this delay were identified as a lack of awareness of rheumatology specialty care among patients (Sjogren’s: 61%; SSc: 74%) and disease management by other specialists (Sjogren’s: 75%; SSc: 62%) rather than rheumatologists. Additionally, over 25% of primary care practitioners were unaware of rheumatology specialty services, and a similar percentage of patients were not diagnosed with rheumatic diseases by their primary care physicians. Patients with delayed referrals for Sjogren’s exhibited higher rates of haematologic, oral, and non-articular pain. Similarly, in SSc patients, delayed referral was associated with a significantly higher prevalence of skin involvement ( P < .01). Conclusion: Patient referrals to other specialties and a lack of knowledge about rheumatology were the primary causes of referral delays. Educating primary care physicians and facilitating direct referrals to rheumatology specialists could help reduce these delays. The study findings may help in stratifying interventions to improve early referral and access to rheumatology specialty care for patients with Sjogren’s and SSc.
Comparing Knowledge and Perceptions of Palliative Care Among Neuro-Oncology Patients, Caregivers, and Providers to a Representative U.S. Sample
Authors: Kim Jung-Young , Dalton Juliet C. , Cort Nicole , Herndon James E. , Affronti Mary L. , Peters Katherine B. , Jones Christopher A. , Johnson Margaret O. 
Published: September 2024

Background Primary brain tumors (PBTs) pose a significant health challenge, affecting patients and their caregivers. While early integration of palliative care (PC) has shown benefits in advanced cancer, its integration for PBT patients, particularly glioblastoma (GBM) patients, remains complex. We hypothesized that our previous PC integration efforts may have failed due to knowledge-gaps and misconceptions among patients, caregivers, and providers. Objective This study aimed to identify knowledge gaps and misconceptions about PC among patients with primary brain tumors (PBTs), their caregivers, and their medical providers. Method An electronic survey was distributed to PBT patients, caregivers, and medical providers, that included questions regarding PC from the Health Information National Trends Survey (HINTS). Survey responses were analyzed; comparisons were made between the 3 groups as well as the general population. Results Of 141 respondents (59 patients, 57 caregivers, and 25 providers), each group held perspectives on PC differing from the general population. While all groups had an improved understanding of PC’s role in symptom management, uncertainty persisted among patients and caregivers regarding life-prolonging treatment and certain PC goals like caregiver support or end-of-life care. Conclusion Understanding gaps in knowledge and perceptions of PC among PBT patients and caregivers is crucial for effective intervention, with caregivers playing a vital role in advocating for PC. Future research should explore factors influencing these perceptions and development of targeted education to improve early PC referrals for patients with PBTs.
Experiences of students with chronic illness in university education in Ireland
Authors: Doris Olga , Morrissey Eimear C 
Published: September 2024

Objective The aim of this study was to explore the experiences of university students with a chronic illness in Ireland. The study also aimed to gain insight into students’ experiences with Disability Support Services (DSS) and identify gaps where additional supports and resources are needed. Design Cross-sectional qualitative study. Methods Fourteen students from three Irish universities participated in semi-structured interviews. The interviews were audio-recorded, transcribed, and analysed through the six-step process of reflexive thematic analysis. Results Four themes were developed: (1) The burden of managing a chronic illness alongside university education; (2) Interruptions, disruptions and alterations to college life; (3) Flexible supports for fluctuating conditions; (4) Achieving in educating while living with a chronic illness. Conclusions Participants reported a physical and emotional burden. Despite engaging in rigorous management strategies, many participants missed lectures and socialising with peers. Some found the supports from DSS to be useful, however many were unsure if they qualified for support, or found the supports available to be generic and inadequate for their needs. There is significant scope for the delivery of both teaching and DSS to be improved for this cohort, ensuring that all students, regardless of their health status, have equal opportunities for success.