bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximum Energy Extraction Control for Wind Power Generation Systems Based on the Fuzzy Controller
Authors: Kamal Elkhatib , Aitouche Abdel , Mohammed Walaa , Sobaih Abdel Azim 
Published: October 2016

Abstract
This paper presents a robust controller for a variable speed wind turbine with a squirrel cage induction generator (SCIG). For variable speed wind energy conversion system, the maximum power point tracking (MPPT) is a very important requirement in order to maximize the efficiency. The system is nonlinear with parametric uncertainty and subject to large disturbances. A Takagi-Sugeno (TS) fuzzy logic is used to model the system dynamics. Based on the TS fuzzy model, a controller is developed for MPPT in the presence of disturbances and parametric uncertainties. The proposed technique ensures that the maximum power point (MPP) is determined, the generator speed is controlled and the closed loop system is stable. Robustness of the controller is tested via the variation of model’s parameters. Simulation studies clearly indicate the robustness and efficiency of the proposed control scheme compared to other techniques.
SVM–ELM: Pruning of Extreme Learning Machine with Support Vector Machines for Regression
Authors: Mahmood Saif F. , Marhaban Mohammad H. , Rokhani Fakhrul Z. , Samsudin Khairulmizam , Arigbabu Olasimbo Ayodeji 
Published: October 2016

AbstractExtreme Learning Machine provides very competitive performance to other related classical predictive models for solving problems such as regression, clustering, and classification. An ELM possesses the advantage of faster computational time in both training and testing. However, one of the main challenges of an ELM is the selection of the optimal number of hidden nodes. This paper presents a new approach to node selection of an ELM based on a 1-norm support vector machine (SVM). In this method, the targets of SVM yi ∈{+1, –1} are derived using the mean or median of ELM training errors as a threshold for separating the training data, which are projected to SVM dimensions. We present an integrated architecture that exploits the sparseness in solution of SVM to prune out the inactive hidden nodes in ELM. Several experiments are conducted on real-world benchmark datasets, and the results attained attest to the efficiency of the proposed method.
High Speed Inter-Satellite Communication System by Incorporating Hybrid Polarization-Wavelength Division Multiplexing Scheme
Authors: Chaudhary Sushank , Chaudhary Neha , Sharma Saurabh , Choudhary BC 
Published: October 2016

AbstractInter-Satellite communication is one of remarkable technologies that can be used to communicate between satellites. This work is focused to carry out the investigations of polarization scheme by incorporating dense wavelength division multiplexing (DWDM) scheme in inter-satellite communication system. A 20×6 Gbps data are transported over inter-satellite optical link having span of 5,000 km to realize the total data transmission of 120 Gbps. Moreover, results are also reported with the effect of RZ and NRZ modulation schemes. The performance of proposed inter-satellite communication link is measured in terms of signal-to-noise ratio, received power and eye diagrams.
Impact of Visual Corticostriatal Loop Disruption on Neural Processing within the Parahippocampal Place Area
Authors: Nasr Shahin , Rosas Herminia D. 
Published: October 2016

The caudate nucleus is a part of the visual corticostriatal loop (VCSL), receiving input from different visual areas and projecting back to the same cortical areas via globus pallidus, substantia nigra, and thalamus. Despite perceptual and navigation impairments in patients with VCSL disruption due to caudate atrophy (e.g., Huntington's disease, HD), the relevance of the caudate nucleus and VCSL on cortical visual processing is not fully understood. In a series of fMRI experiments, we found that the caudate showed a stronger functional connection to parahippocampal place area (PPA) compared with adjacent regions (e.g., fusiform face area, FFA) within the temporal visual cortex. Consistent with this functional link, the caudate showed a higher response to scenes compared with faces, similar to the PPA. Testing the impact of VCSL disruption on neural processes within PPA, HD patients showed reduced scene-selective activity within PPA compared with healthy matched controls. In contrast, the level of selective activity in adjacent cortical and subcortical face-selective areas (i.e., FFA and amygdala) remained intact. These results show some of the first evidence for the direct impact and potential clinical significance of VCSL on the generation of “selective” activity within PPA.SIGNIFICANCE STATEMENTVisual perception is often considered the product of a multistage feedforward neural processing between visual cortical areas, ignoring the likely impact of corticosubcortical loops on this process. Here, we provide evidence for the contribution of visual corticostriatal loop and the caudate nucleus on generating selective response within parahippocampal place area (PPA). Our results show that disruption of this loop in Huntington's disease patients reduces the level of selective activity within PPA, which may lead to related perceptual impairments in these patients.
Methamphetamine Regulation of Firing Activity of Dopamine Neurons
Authors: Lin Min , Sambo Danielle , Khoshbouei Habibeh 
Published: October 2016

Methamphetamine (METH) is a substrate for the dopamine transporter that increases extracellular dopamine levels by competing with dopamine uptake and increasing reverse transport of dopamine via the transporter. METH has also been shown to alter the excitability of dopamine neurons. The mechanism of METH regulation of the intrinsic firing behaviors of dopamine neurons is less understood. Here we identified an unexpected and unique property of METH on the regulation of firing activity of mouse dopamine neurons. METH produced a transient augmentation of spontaneous spike activity of midbrain dopamine neurons that was followed by a progressive reduction of spontaneous spike activity. Inspection of action potential morphology revealed that METH increased the half-width and produced larger coefficients of variation of the interspike interval, suggesting that METH exposure affected the activity of voltage-dependent potassium channels in these neurons. Since METH has been shown to affect Ca2+homeostasis, the unexpected findings that METH broadened the action potential and decreased the amplitude of afterhyperpolarization led us to ask whether METH alters the activity of Ca2+-activated potassium (BK) channels. First, we identified BK channels in dopamine neurons by their voltage dependence and their response to a BK channel blocker or opener. While METH suppressed the amplitude of BK channel-mediated unitary currents, the BK channel opener NS1619 attenuated the effects of METH on action potential broadening, afterhyperpolarization repression, and spontaneous spike activity reduction. Live-cell total internal reflection fluorescence microscopy, electrophysiology, and biochemical analysis suggest METH exposure decreased the activity of BK channels by decreasing BK-α subunit levels at the plasma membrane.SIGNIFICANCE STATEMENTMethamphetamine (METH) competes with dopamine uptake, increases dopamine efflux via the dopamine transporter, and affects the excitability of dopamine neurons. Here, we identified an unexpected property of METH on dopamine neuron firing activity. METH transiently increased the spontaneous spike activity of dopamine neurons followed by a progressive reduction of the spontaneous spike activity. METH broadened the action potentials, increased coefficients of variation of the interspike interval, and decreased the amplitude of afterhyperpolarization, which are consistent with changes in the activity of Ca2+-activated potassium (BK) channels. We found that METH decreased the activity of BK channels by stimulating BK-α subunit trafficking. Thus, METH modulation of dopamine neurotransmission and resulting behavioral responses is, in part, due to METH regulation of BK channel activity.
Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells
Authors: Früh Simon , Romanos Jennifer , Panzanelli Patrizia , Bürgisser Daniela , Tyagarajan Shiva K. , Campbell Kevin P. , Santello Mirko , Fritschy Jean-Marc 
Published: October 2016

Distinct types of GABAergic interneurons target different subcellular domains of pyramidal cells, thereby shaping pyramidal cell activity patterns. Whether the presynaptic heterogeneity of GABAergic innervation is mirrored by specific postsynaptic factors is largely unexplored. Here we show that dystroglycan, a protein responsible for the majority of congenital muscular dystrophies when dysfunctional, has a function at postsynaptic sites restricted to a subset of GABAergic interneurons. Conditional deletion ofDag1, encoding dystroglycan, in pyramidal cells caused loss of CCK-positive basket cell terminals in hippocampus and neocortex. PV-positive basket cell terminals were unaffected in mutant mice, demonstrating interneuron subtype-specific function of dystroglycan. Loss of dystroglycan in pyramidal cells had little influence on clustering of other GABAergic postsynaptic proteins and of glutamatergic synaptic proteins. CCK-positive terminals were not established at P21 in the absence of dystroglycan and were markedly reduced when dystroglycan was ablated in adult mice, suggesting a role for dystroglycan in both formation and maintenance of CCK-positive terminals. The necessity of neuronal dystroglycan for functional innervation by CCK-positive basket cell axon terminals was confirmed by reduced frequency of inhibitory events in pyramidal cells of dystroglycan-deficient mice and further corroborated by the inefficiency of carbachol to increase IPSC frequency in these cells. Finally, neurexin binding seems dispensable for dystroglycan function because knock-in mice expressing binding-deficient T190M dystroglycan displayed normal CCK-positive terminals. Together, we describe a novel function of dystroglycan in interneuron subtype-specific trans-synaptic signaling, revealing correlation of presynaptic and postsynaptic molecular diversity.SIGNIFICANCE STATEMENTDystroglycan, an extracellular and transmembrane protein of the dystrophin-glycoprotein complex, is at the center of molecular studies of muscular dystrophies. Although its synaptic distribution in cortical brain regions is long established, function of dystroglycan in the synapse remained obscure. Using mice that selectively lack neuronal dystroglycan, we provide evidence that a subset of GABAergic interneurons requires dystroglycan for formation and maintenance of axonal terminals on pyramidal cells. As such, dystroglycan is the first postsynaptic GABAergic protein for which an interneuron terminal-specific function could be shown. Our findings also offer a new perspective on the mechanisms that lead to intellectual disability in muscular dystrophies without associated brain malformations.
Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex
Authors: Armbruster Moritz , Hanson Elizabeth , Dulla Chris G. 
Published: October 2016

Excitatory amino acid transporters (EAATs) are abundantly expressed by astrocytes, rapidly remove glutamate from the extracellular environment, and restrict the temporal and spatial extent of glutamate signaling. Studies probing EAAT function suggest that their capacity to remove glutamate is large and does not saturate, even with substantial glutamate challenges. In contrast, we report that neuronal activity rapidly and reversibly modulates EAAT-dependent glutamate transport. To date, no physiological manipulation has shown changes in functional glutamate uptake in a nonpathological state. Using iGluSnFr-based glutamate imaging and electrophysiology in the adult mouse cortex, we show that glutamate uptake is slowed up to threefold following bursts of neuronal activity. The slowing of glutamate uptake depends on the frequency and duration of presynaptic neuronal activity but is independent of the amount of glutamate released. The modulation of glutamate uptake is brief, returning to normal within 50 ms after stimulation ceases. Interestingly, the slowing of glutamate uptake is specific to activated synapses, even within the domain of an individual astrocyte. Activity-induced slowing of glutamate uptake, and the increased persistence of glutamate in the extracellular space, is reflected by increased decay times of neuronal NR2A-mediated NMDA currents. These results show that astrocytic clearance of extracellular glutamate is slowed in a temporally and spatially specific manner following bursts of neuronal activity ≥30 Hz and that these changes affect the neuronal response to released glutamate. This suggests a previously unreported form of neuron–astrocyte interaction.SIGNIFICANCE STATEMENTWe report the first fast, physiological modulation of astrocyte glutamate clearance kinetics. We show that presynaptic activity in the cerebral cortex increases the persistence of glutamate in the extracellular space by slowing its clearance by astrocytes. Because of abundant EAAT expression, glutamate clearance from the extracellular space has been thought to have invariant kinetics. While multiple studies report experimental manipulations resulting in altered EAAT expression, our findings show that astrocytic glutamate uptake is dynamic on a fast time-scale. This shows rapid plasticity of glutamate clearance, which locally modulates synaptic signaling in the cortex. As astrocytic glutamate uptake is a fundamental and essential mechanism for neurotransmission, this work has implications for neurotransmission, extrasynaptic receptor activation, and synaptic plasticity.
TAXONOMY AND GENETIC RELATIONSHIPS OF PANGASIIDAE, ASIAN CATFISHES, BASED ON MORPHOLOGICAL AND MOLECULAR ANALYSES
Authors: Gustiano Rudhy , Pouyaud Laurent 
Published: October 2016

<p>Pangasiids are economically important riverine catfishes generally residing in freshwater from the Indian subcontinent to the Indonesian Archipelago. The systematics of this family are still poorly known. Consequently, lack of such basic information impedes the understanding of the biology of the Pangasiids and the study of their aquaculture potential as well as improvement of seed production and growth performance. The objectives of the present study are to clarify phylogeny of this family based on a biometric analysis and molecular evidence using 12S ribosomal mtDNA on the total of 1070 specimens. The study revealed that 28 species are recognised as valid in Pangasiidae. Four genera are also recognized as Helicophagus Bleeker 1858, Pangasianodon Chevey 1930, Pteropangasius Fowler 1937, and Pangasius Valenciennes 1840 instead of two as reported by previous workers. The phylogenetic analysis demonstrated the recognised genera, and genetic relationships among taxa. Overall, trees from the different analyses show similar topologies and confirm the hypothesis derived from geological history, palaeontology, and similar models in other taxa of fishes from the same area. The oldest genus may already have existed when the Asian mainland was still connected to the islands in the southern part about 20 million years ago.</p>
IKAN PARI AIR TAWAR DAN SEJENISNYA SEBAGAI IKAN HIAS YANG POTENSIAL
Authors: Sudarto Sudarto 
Published: October 2016

Ikan pari air tawar Himantura signifer termasuk genus Himantura yang terdiri atas 40 spesies. Ikan ini banyak diburu orang untuk dijadikan ikan hias. Akibat perburuan tersebut maka ikan ini menjadi langka di beberapa habitatnya antara lain di Jambi, Kalimantan, dan Papua. Oleh karena itu, diperlukan upaya untuk merehabilitasi habitat maupun populasinya di alam melalui restocking dan konservasi habitat. Uji coba pembiakan sedang dilakukan dan diharapkan keberhasilan pengembangbiakannya dapat memperbaiki populasi ikan ini di alam.
Addiction care in Mexico: a challenge for non-specialized health professionals
Authors: Marín-Navarrete Rodrigo ,   Unidad de Ensayos Clínicos en Adicciones y Salud Mental, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz., Medina-Mora María Elena , Tena-Suck Antonio ,   Dirección General. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz.,   Departamento de Psicología, Universidad Iberoamericana Ciudad de México.
Published: October 2016

International epidemiological studies report that substance use disorders (SUDs) and other psychiatric disorders (anxiety and depression) are among the first ten conditions that contribute to the global burden of disease. Together they account for 7.4% of the disability-adjusted life years of the total global burden, 0.5% of the total years of life lost to premature mortality, and 22.9% of the years lived with disability. These data place SUDs as a serious public health problem in the world.
Increase of PlGF (Placental Growth Factor) Level After Administration of Dydrogesterone in Pregnancy
Authors: Rusly Dewi Karlina 
Published: October 2016

<p><strong>Aim:</strong> To observe the effect of Dydrogesterone administration in pregnancy on PlGF level</p><p><strong>Methods:</strong> This is a randomized controlled clinical trial. Study population has been divided into two groups. Group A consists of 20 women who receive only Folic acid 5 mg a day for 4 weeks time. Group B consists of 20 women who receive Dydrogesterone 2x10 mg a day and Folic acid 5 mg a day for 4 weeks. PlGF has been measured twice. First measurement was done before drug administration, while the second measurement has been done during 18<sup>th</sup> weeks of pregnancy. The changes on PlGF level before and after treatment from each group has been analyzed using SPSS 17.</p><p><strong>Results:</strong> 40 pregnant women have been recruited for this study. There are no differences based on the patient’s age, number of pregnancy and parity, gestational age and body weight between each group. The mean levels of PlGF in both groups before intervention shows no significant difference (p = 0091 or p&gt; 0.05), 40.80 pg/mL vs. 25.95 pg / mL. The mean levels of PlGF in group A after 4 weeks administration of Folic acid is 89.60 pg / mL. It shows the escalation of 48.8 pg / mL. The elevation of PlGF level in group A shows significant difference (p = 0.000 or p &lt;0.05) after 4 weeks Folic acid treatment.The mean levels of PlGF in group B after 4 weeks administration of Dydrogesterone and Folic acid is 212.15 pg / mL. It shows the escalation of 186.20 pg / mL. The elevation of PlGF level in group B shows significant difference (p = 0.000 or p &lt;0.05) after 4 weeks Dydrogesterone and Folic acid treatment.</p><p><strong>Conclusion:</strong> Dydrogesterone treatment can increase the level of PlGF.</p>
The Association Between Sperm DNA Fragmentation and Idiopathic Early Recurrent Pregnancy Loss
Authors: Halim Binarwan 
Published: October 2016

<p><strong>Introduction</strong></p><p>Various etiologies of recurrent pregnancy loss (RPL) have been extensively studied, but more than half of them still remain unknown. Male factor may play a role in incidence of idiopathic early recurrent pregnancy loss. Sperm DNA fragmentation as one of sperm test for male factor can be measured and expressed by a DNA Fragmentation Index (DFI). The aim of the study is to evaluate the association between sperm DNA fragmentation and the incidence of idiopathic early recurrent pregnancy loss.</p><p><strong>Material &amp; Methods</strong></p><p>A prospective study was done by recruiting 40 cases of male couple from patients with a history of idiopathic early recurrent pregnancy loss and 40 cases of control from normal fertile population from May 2010 to September 2011 in Halim Fertility Center. Sperm DNA fragmentation was detected by halosperm kit.</p><p><strong>Results</strong><br />Both of groups were comparable in terms of the age of male patients, body mass index, duration of infertility, history of miscarriage and sperm parameters. Sperm DFI in the case group was 34.12%. and in the control group was 16.02%. There was significantly higher sperm DFI in the case group than in the control group. Sperm DFI &lt;30 was increased in control group (95%) compared with case group (40%). Sperm DFI ≥30 was increased in case group (60%) compared with control group (5%). There was a significant association between sperm DFI ≥30 and idiopathic early recurrent pregnancy loss (p&lt;0,05).</p><p><strong>Conclusion</strong></p><p>There is an association between higher sperm DNA fragmentation and incidence of idiopathic early recurrent pregnancy loss.</p>
Outcome and Risk of Obstetric Complication in Teenage Pregnancy in Tertiary Center Hospital In Indonesia
Authors: Andriyana Huthia 
Published: October 2016

<p><strong>Background : </strong>Teenage pregnancy is a worldwide problem bearing serious social and medical implications relating to maternal and child health. Teenage pregnancy can have serious physical consequences and they are likely to be unmarried and uneducated. The objective of the study was to evaluate risk factors associated with teenage pregnancy and compare the obstetric and fetal outcome.<strong></strong></p><p><strong>Methods :</strong> This is a retrospective study performed over a period of 2 years (January 1, 2013 to December 31, 2014) in Dr. Cipto Mangunkusumo Hospital as tertiary center and teaching hospital in Indonesia where data was retrieved from the hospital records. Three hundred and fifty randomly selected teenage mothers (aged 12-18) who had delivery within the period were compared with 350 randomly selected deliveries in older primigravid mother (19-39 years) over the same period. Variables of interest were the demographic characteristics of the women, their obstetric complications and the outcome.</p><p><strong>Results :</strong> There were a total of 5449 deliveries during the study period, out which 372 (6.8%) were teenages. We compared 350 randomly selected teenage mothers (aged 12-18 years) with 350 randomly selected primigravid mothers (aged 19-39) over the same period. In teenage group, the mean of age was 17,3 years old, most of the teenage mother latest education were junior high school (78,3%), unemployed (55,1%), married &lt; 6 month (40,8%), unintended pregnancy (56,6%), labor husband occupation (56%).</p><p>The obstetrical complications of teenage mother were premature rupture of membrane (27,3%), preterm labor (20,9%), gestational hypertension, mild-severe preeclampsia (12,3%), intrauterine infection (10,3%), postterm pregnancy (5,7%), eclampsia (3,7%), fetal malpresentation (3,7%), labor dystocia (3,4%), HIV (0,9%) and condyloma (1,7%). Most of babies were delivered vaginally (61,3%) in gestational age under 36 weeks (57,7%) with babies birth weight under 2500 grams (51,7%). Most of teenage mother were having IUD as contraception (78,9%).</p><strong>Conclusion :</strong> Teenage pregnancy in Indonesia is concentrated among women with less education, who are unemployed, unmarried and with inadequate antenatal care and obstetric risks for poor pregnancy outcome.