bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adapting to climate change: lessons from Chile’s coastal communities
Authors: Parra Jessica , Jensen Magdalena 
Published: October 2024

Purpose
This study aims to examine the intricate relationship between Chile’s coastal communities and the increasing effects of climate change, with a focus on Caleta Lenga as a case study. Chile’s extensive coastline is closely linked to the country’s economic well-being and the livelihoods of millions of people. The mounting threats posed by climate change require immediate action. To strengthen resilience and reduce risk, adaptive measures are imperative. However, effective adaptation is hindered by numerous barriers, including adaptive capacity and governance challenges.

Design/methodology/approach
This study uses a case study approach, which centres on Caleta Lenga’s unique socio-environmental and demographic context. This study used semi-structured interviews and historical reconstruction to reveal a socio-economic and environmental narrative that was influenced by significant events and transitions.

Findings
The residents’ perception of climate change impacts was viewed through the lens of industrial activities and changing weather patterns. This study emphasizes the community’s resilience in the face of changing socio-environmental dynamics. It highlights the importance of informed decision-making, community cooperation and the preservation of ancestral knowledge in promoting adaptive strategies based on community solidarity and collective decision-making. The findings underscore the need for effective adaptation measures that address both adaptive capacity and governance challenges to bolster climate resilience in vulnerable coastal communities.

Originality/value
The findings underscore the need for effective adaptation measures that address both adaptive capacity and governance challenges to bolster climate resilience in vulnerable coastal communities.
Investigating social streaming app dependency: a mixed-methods analysis
Authors: Xu Xiaoyu , Tayyab Syed Muhammad Usman , Luo Xin (Robert) , Lee Frank C. , Jia Qingdan 
Published: October 2024

PurposeThere is a dearth of knowledge regarding how user dependency offers valuable resources to develop the intellectual capital of social streaming apps (SSAs) companies. This study aims to integrate major conceptual components of the UandD model, identify contextualized goal-oriented SSA dependency and empirically evaluate their interrelated user-dependency relationships in the SSA context.Design/methodology/approachA mixed-methods approach was utilized in this study. First, user gratifications were elicited through a qualitative approach, considering the exploratory stage of the SSA phenomenon. Second, statistical methods were applied to investigate and extract the sub-dimensions of SSA dependency. At last, a research model was developed grounded on the UandD model and empirically validated using the quantitative approach.FindingsThe results validated the gratification-dependency-attitude-behavior relationships hypothesized by the UandD framework in SSA. The role of user-SSA dependency in enhancing intellectual capital in the social media industry has been highlighted in this study.Research limitations/implicationsThis research not only provides an opportunity for the UandD model to realize its theoretical potential as envisioned by scholars but also contributes to the scholarship on social streaming apps and media dependency theory by conceptualizing goal-oriented dependency in SSAs.Practical implicationsThe research results will guide digital media practitioners to a more nuanced understanding of the relationships between their users and modern digital media apps and thus empower the practitioners to better manage their intellectual capital based on the facilitation of their users’ dependency.Originality/valueThis work is one of the pioneers in contextualizing the UandD model in the SSA field, refining and measuring the SSA dependency and its distinct subdimensions and employing mixed-methods to offer a comprehensive understanding of how user dependency boosts intellectual capital in the SSA industry.
Enabling sustainable circular economy in Indian municipal solid waste management system: an ISM and fuzzy MICMAC approach
Authors: Pati Smeetasree , Agrawal Rajat 
Published: October 2024

PurposeMismanagement of municipal solid waste (MSW) has led to resource depletion, ecosystem degradation and socio-economic risks, emphasizing the necessity to promote sustainable circular economy (SuCE) practices. This article identifies relevant enablers and unveils their interconnected roles in facilitating a municipal solid waste management (MSWM) system aligned with the principles of SuCE.Design/methodology/approachTo identify pertinent enablers for MSWM systems based on SuCE principles, the study conducted a literature review and engaged experts from waste management sectors and academia to consolidate the final list of enablers. Following this, the study investigated the inter-relationships among these enablers using both Interpretive Structural Modeling (ISM) integrated and fuzzy Matrix Impact Cross-Reference Multiplication Applied to a Classification (fuzzy MICMAC) with MATLAB.FindingsThe study identified a comprehensive set of 23 enablers and categorized them into four control measures instrumental for the effective integration of SuCE principles in the context of the Indian MSWM system. Notably, the analysis highlighted that “authoritative pressure” and “policy transformation” are the highly influential enablers.Practical implicationsThe study emphasizes actionable implications for stakeholders in the Indian MSWM sector. Policymakers and governmental bodies can enforce “authoritative pressure,” “policy transformation” and “budget allocation”. Meanwhile, managers can focus on “promotion of SuCE awareness”, “formalizing the informal workforce”, “infrastructure modernization”, “stakeholder engagement and alignment”, “segregation strategy”, “disruption preparedness”, and “local-based strategy”.Originality/valueThis study proposed a unique ISM diagraph and cluster of enablers to enhance the novelty of the study.
Pregnancy‐Associated Maternal Mortality Within One Year After Childbirth: Population‐Based Cohort Study
Authors: Arshad Nadia , Skjærven Rolv , Klungsøyr Kari , Sørbye Linn Marie , Kvalvik Liv Grimstvedt , Morken Nils‐Halvdan 
Published: October 2024

ABSTRACTObjectiveThe objective of this study is to assess associations between pregnancy complications and pregnancy‐associated maternal mortality (PAM) within 1 year after childbirth.DesignPopulation‐based cohort study.SettingNorway, 1967–2020.Population1 237 254 mothers with one or more singleton pregnancies registered in the Medical Birth Registry, 1967–2019 and followed in the Cause of Death Registry to 2020.MethodsLogistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for maternal education, age, year of first childbirth and chronic medical conditions.Main Outcome MeasuresPAM by lifetime history of pregnancy complications: placental abruption, preeclampsia, preterm birth, perinatal death, small for gestational age (< 2.5 percentile), gestational diabetes and gestational hypertension.ResultsCrude OR for PAM was 4.24 (95% CI 3.53–5.10), if complications occurred in the last pregnancy, whereas 2.52 (2.08–3.06) if complications occurred in the first pregnancy, compared to mothers without complications in any pregnancy. Adjusted ORs for PAM when complications occurred in the last pregnancy were, for placental abruption 3.75 (1.20–11.72), preeclampsia: 4.42 (3.17–6.15), preterm birth: 4.32 (3.25–5.75), perinatal death: 24.18 (16.66–35.08), small for gestational age: 2.90 (1.85–4.54), gestational diabetes: 1.43 (0.63–3.25) and pregnancy hypertension: 2.05 (1.12–3.74) compared to mothers without complications. The OR for PAM increased slightly by increasing the number of complicated pregnancies but the trend was stronger for increasing number of complications in the last pregnancy (e.g., during 1999–2019: one complication; 4.14 [2.79–6.13], two complications; 11.50 [6.81–19.43]).ConclusionComplications in the last pregnancy were more strongly associated with PAM than those in the first pregnancy.
Olokizumab effect on chronic pain in rheumatoid arthritis: Results of the PROLOGUE observational study
Authors: Karateev А. Е. , Polishchuk Е. Y. , Filatova Е. S. , Amirdzhanova V. N. , Khlaboshina V. N. , Lila А. М. , Baranov A. A. , Lapkina N. A. , Togizbayev G. A. 
Published: October 2024

AbstractAimEvaluate the efficacy and safety ® (olokizumab) in patients with rheumatoid arthritis (RA) in real‐world clinical practice, with a targeted assessment of patient report outcomes (PRO) and central sensitization.MethodsAn open‐label observational non‐interventional study was conducted, enrolling 183 patients with moderate and severe RA activity. All patients received OKZ 64 mg SC as injections every 4 weeks (Q4W) with methotrexate. The patients' follow‐up period was 24 weeks or less. RA activity (DAS28‐CRP), pain severity (NRS), patient global assessment (PGA, NRS), functional impairment (NRS), fatigue (FACIT‐F), central sensitization (central sensitization inventory, CSI), and symptoms of neuropathic pain (PainDETECT) were evaluated.ResultsThe study cohort was comprised of 144 patients. And 39 patients were lost to follow‐up, refused OKZ treatment, or were not dosed with OKZ for administrative reasons. In 6 months, DAS28‐CRP decreased to 3.3 ± 0.9 (p < .001) and statistically significant reductions in pain intensity, PGA, functional impairment, and fatigue were achieved. Pain intensity decreased as early as 2 days after the first OKZ administration (p < .05). The number of patients with CSI >40 in 24 weeks decreased from 71.0% to 21.0% (p < .001), with PainDETECT >18 – from 21.5% to 13.2%. NSAIDs use decreased from 70.8% to 33.8% (р < .001), steroids – from 54.2% to 32.6%. AEs were reported in 14.2% patients, serious events were observed in three patients.ConclusionOKZ is effective in reducing RA activity and controlling chronic pain related to dysfunction of the nociceptive system.
Cellular senescence contributes to spontaneous repair of the rat meniscus
Authors: Aimono Yusuke , Endo Kentaro , Sekiya Ichiro 
Published: October 2024

AbstractCellular senescence, traditionally associated with aging and chronic diseases, has recently been identified as a potential facilitator of tissue regeneration via a senescence‐associated secretory phenotype (SASP). In rodents, the meniscus is known to regenerate spontaneously from the surrounding synovium, but the mechanism, and especially its relationship to cellular senescence, remains unclear. This study investigated the contribution of cellular senescence to spontaneous repair of the rat meniscus. We created a rat partial medial meniscectomy (pMx) model to evaluate time‐course changes in regenerative tissue. Immunohistochemistry revealed marked increases in p16 expression and senescence‐associated beta‐galactosidase (SA‐β‐gal) activity in the regenerating tissue at the early phase after pMx surgery. RNA sequencing of regenerating tissues identified the upregulation of genes related to aging, extracellular matrix organization, and cell proliferation. Fluorescence staining identified high expression of SOX9, a master regulator of cartilage/meniscus development, adjacent to p16‐positive cells. In vitro investigations of the effect of SASP factors on synovial fibroblasts (SFs) demonstrated that conditioned medium from senescent SFs stimulated the proliferation and chondrogenic differentiation of normal SFs. In vivo histological evaluation to determine whether selective elimination of senescent cells with a senolytic drug (ABT‐263) retarded spontaneous repair of meniscus in vivo confirmed that ABT‐263 decreased the meniscus score and expression of SOX9, aggrecan, and type 1 collagen. Our findings indicate that transient senescent cell accumulation and SASP in regenerating tissues beneficially contribute to spontaneous repair of the rat meniscus. Further research into the molecular mechanism will provide a novel strategy for meniscus regeneration based on cellular senescence.
Scoping Review of Microbiota Dysbiosis and Risk of Preeclampsia
Authors: Jordan Madeleine M. , Amabebe Emmanuel , Khanipov Kamil , Taylor Brandie DePaoli 
Published: October 2024

ABSTRACTLimited studies have investigated the role of the microbiota in hypertensive disorders of pregnancy (HDP), particularly preeclampsia, which often results in preterm birth. We evaluated 23 studies that explored the relationship between gut, vaginal, oral, or placental microbiotas and HDP. Scopus, ProQuest Health Research Premium Collection, ProQuest Nursing & Allied Health Database, EBSCO, and Ovid were searched for relevant literature. Majority (18) of studies focused on the gut microbiota, and far fewer examined the oral cavity (3), vagina (3), and placenta (1). One study examined the gut, oral, and vaginal microbiotas. The consensus highlights a potential role for microbiota dysbiosis in preeclampsia and HDP. Especially in the third trimester, preeclampsia is associated with gut dysbiosis—deficient in beneficial species of Akkermansia, Bifidobacterium, and Coprococcus but enriched with pathogenic Campylobacterota and Candidatus Saccharibacteria, with low community α‐diversity. Similarly, the preeclamptic vaginal and oral microbiotas are enriched with bacterial vaginosis and periodontal disease‐associated species, respectively. The trend is also observed in the placenta, which is colonized by gastrointestinal, respiratory tract, and periodontitis‐related pathogens. Consequently, a chronic proinflammatory state that adversely impacts placentation is implicated. These observations however require more mechanistic studies to establish the timing of the preceding immune dysfunction and any causality.
Intra‐operative neuromonitoring in paediatric spinal deformity surgery: a retrospective single‐centre experience
Authors: Ma Norine , Saunders Ann , Moylan Laura , Johnson Michael B. , Ryan Monique , Yiu Eppie , Liew Susan 
Published: October 2024

AbstractIntroductionIntra‐operative neuromonitoring including somatosensory evoked potentials, motor evoked potentials, and electromyography, have replaced the Stagnara wake‐up test to allow early detection of neurological change during paediatric spinal deformity surgery. It is important for surgeons to recognize alerts triggered by loss of these potentials and act accordingly to prevent iatrogenic neurological damage intra‐operatively. This study was conducted to determine the sensitivity and specificity of neuromonitoring alerts in paediatric spinal deformity correction surgery.MethodsA retrospective single‐centre study of all patients undergoing spinal deformity surgery at a tertiary paediatric centre between 1 January 2017 and 31 December 2020 (inclusive) was conducted. Neuromonitoring alerts were identified through neurophysiology documentation, and these were correlated with neurological deficits documented in the patient record post‐operatively.ResultsA total of 399 operations were included in the study, with 147 (35.7%) of these having a motor, or motor and sensory alert triggered. Fifteen (10.2% of alerts) of these patients had a post‐operative neurological deficit, compared to seven (2.8% of no alerts) of those that had no neuromonitoring alert. The sensitivity for post‐operative neurological deficits not resolving within 3 days was 100%, and the specificity was 65.5%.ConclusionIntra‐operative neuromonitoring is highly sensitive to post‐operative neurological deficits lasting longer than 3 days. However, there is still scope for optimization of specificity, with many false positives identified.
Strabismus surgery in topical anaesthesia with intraoperative suture adjustment in Graves' orbitopathy
Authors: Haugen Olav H. , Mellgren Anne Elisabeth Christensen , Norli Maren , Ueland Hans Olav 
Published: October 2024

AbstractPurposeTo report the results of strabismus surgery in a series of patients with Graves' orbitopathy (GO), using topical anaesthesia with intraoperative suture adjustment.MethodsAll first‐time strabismus surgeries in patients with GO in our department during the years 2014–2021 (n = 45) were assessed retrospectively. Among these, 31% came from outside our health region due to increased complexity of the strabismus condition. Orbital decompression surgery had been carried out in 58% of the patients prior to strabismus surgery. Patients with less than 2 months of follow‐up were excluded from the study. Median follow‐up time was 22 months.ResultsAmong the total patient material, 37 (82%) could be operated with topical anaesthesia with intraoperative suture adjustment. There were no cases with triggering of the oculo‐cardiac reflex during the procedure. Among the 36 patients operated with topical anaesthesia and follow‐up time ≥2 months, 11 (31%) needed further surgery. Late overcorrection after recession of the inferior rectus was seen in 19%. At the last control examination, 32 (89%) were diplopia‐free in primary and down‐gaze position, either with or without weak prisms.ConclusionStrabismus surgery in topical anaesthesia with intraoperative suture adjustment appears to be a suitable and safe procedure in most patients with GO, including difficult and complex cases. The patients should be informed about the possibility of additional surgery and/or post‐operative need for prism glasses.
Mini‐percutaneous nephrolithotomy vs flexible ureteroscopy for 1–2 cm lower pole renal stones: a randomised controlled trial
Authors: Elmansy Hazem , Fathy Moustafa , Hodhod Amr , Alaref Amer , Hadi Ruba Abdul , Abbas Loay , Alaradi Husain , Labib Yasser , Shahrour Walid , Zakaria Ahmed S. 
Published: October 2024

ObjectiveTo compare the safety and efficacy of flexible ureteroscopy (f‐URS) and ambulatory tubeless mini‐percutaneous nephrolithotomy (mini‐PCNL) in the treatment of 1–2 cm lower calyceal renal stones.Patients and MethodsPatients who underwent f‐URS and mini‐PCNL for the treatment of 1–2 cm lower calyceal renal stones between October 2020 and November 2023 were evaluated in a randomised controlled trial. A total of 72 patients were included in the study. All patients underwent a computed tomography renal colic scan preoperatively, on postoperative Day 1 (POD 1), and at 3 months follow‐up. We compared perioperative outcomes, including operative time and hospital stay. Additionally, we evaluated follow‐up outcomes, such as the stone‐free rate (SFR) and complications. All patients were discharged home on the same operative day.ResultsThere were no significant differences in preoperative baseline data between the two surgical groups. A significantly longer median operative time was reported in the mini‐PCNL group (P = 0.04). The median hospital stay was 5 h and 4 h in the mini‐PCNL and f‐URS groups, respectively (P = 0.14). On POD 1, the SFR, defined as the absence of residual fragments measuring 0 cm, was 50% for mini‐PCNL vs 11.1% for f‐URS (P < 0.001). When a total cut‐off of <0.4 cm was utilised, the SFR was 75% in the mini‐PCNL group vs 22.2% in the f‐URS cohort (P < 0.001). At 3 months follow‐up, the SFR remained favourable for mini‐PCNL at 72.2% vs 37.1% for f‐URS (P = 0.003), with a cut‐off of 0 cm, and it increased to 86.1% for mini‐PCNL vs 65.7% for f‐URS (P = 0.04) when a total cut‐off of <0.4 cm was applied. There was no significant difference in postoperative complications between the two groups. Two patients (5.7%) in the f‐URS group required re‐treatment. [Correction added on 5 November 2024, after first online publication: Within the Results section, ‘<4 cm’ has been corrected to ‘<0.4 cm’.]ConclusionsAmbulatory tubeless mini‐PCNL and f‐URS are effective treatment options for 1–2 cm lower calyceal renal stones. Both techniques have a comparable hospital stay and complication rates, with a significantly better SFR with mini‐PCNL.
The cryptonephridial/rectal complex: an evolutionary adaptation for water and ion conservation
Authors: Beaven Robin , Denholm Barry 
Published: October 2024

ABSTRACTArthropods have integrated digestive and renal systems, which function to acquire and maintain homeostatically the substances they require for survival. The cryptonephridial complex (CNC) is an evolutionary novelty in which the renal organs and gut have been dramatically reorganised. Parts of the renal or Malpighian tubules (MpTs) form a close association with the surface of the rectum, and are surrounded by a novel tissue, the perinephric membrane, which acts to insulate the system from the haemolymph and thus allows tight regulation of ions and water into and out of the CNC. The CNC can reclaim water and solutes from the rectal contents and recycle these back into the haemolymph. Fluid flow in the MpTs runs counter to flow within the rectum. It is this countercurrent arrangement that underpins its powerful recycling capabilities, and represents one of the most efficient water conservation mechanisms in nature. CNCs appear to have evolved multiple times, and are present in some of the largest and most evolutionarily successful insect groups including the larvae of most Lepidoptera and in a major beetle lineage (Cucujiformia + Bostrichoidea), suggesting that the CNC is an important adaptation. Here we review the knowledge of this remarkable organ system gained over the past 200 years. We first focus on the CNCs of tenebrionid beetles, for which we have an in‐depth understanding from physiological, structural and ultrastructural studies (primarily in Tenebrio molitor), which are now being extended by studies in Tribolium castaneum enabled by advances in molecular and microscopy approaches established for this species. These recent studies are beginning to illuminate CNC development, physiology and endocrine control. We then take a broader view of arthropod CNCs, phylogenetically mapping their reported occurrence to assess their distribution and likely evolutionary origins. We explore CNCs from an ecological viewpoint, put forward evidence that CNCs may primarily be adaptations for facing the challenges of larval life, and argue that their loss in many aquatic species could point to a primary function in conserving water in terrestrial species. Finally, by considering the functions of renal and digestive epithelia in insects lacking CNCs, as well as the typical architecture of these organs in relation to one another, we propose that ancestral features of these organs predispose them for the evolution of CNCs.
Does working memory training in children need to be adaptive? A randomized controlled trial
Authors: Lau Regine Cassandra , Anderson Peter J. , Gathercole Susan , Wiley Joshua F. , Spencer‐Smith Megan 
Published: October 2024

AbstractMost cognitive training programs are adaptive, despite limited direct evidence that this maximizes children's outcomes. This randomized controlled trial evaluated working memory training with difficulty of activities presented using adaptive, self‐select, or stepwise compared with an active control. At baseline, immediately, and 6‐months post‐intervention, 201 Australian primary school children (101 males, 7–11 years) completed working memory tests (near and intermediate transfer) and the Raven's Standard Progressive Matrices, and caregivers completed the attention‐deficit/hyperactivity disorder‐Rating Scale‐5 (far transfer). The intervention comprised ten 20‐min sessions delivered in class. For each training condition, compared with the active control, there was no evidence of transfer immediately or 6‐months post‐intervention (negligible to small effects). This trial provides no evidence that adaptive working memory training maximizes children's outcomes.