bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive vs. standard remote monitoring of cardiac resynchronization devices in heart failure patients: results of the ECOST-CRT study
Authors: Klein Cédric , Kouakam Claude , Lazarus Arnaud , de Groote Pascal , Bauters Christophe , Marijon Eloi , Mouquet Frédéric , Degand Bruno , Guyomar Yves , Mansourati Jacques , Leclercq Christophe , Guédon-Moreau Laurence ,   ECOST-CRT study Investigators, Guedon-Moreau Laurence , Degand Bruno , Guyomar Yves , Mansourati Jacques , Babuty Dominique , Pons Maxime , Guy-Moyat Benoit , Deharo Jean-Claude , Gras Daniel , Himbert Caroline , Leclercq Christophe , Pasquie Jean-Luc , Eschalier Romain , Marzak Halim , Boursier Michel , Jourda François , Anselme Frédéric , Gorka Hervé , Billon Olivier , Champ-Rigot Laure , Ait Said Mina , Taieb Jérôme , Badoz Marc , Laborderie Julien , Belhameche Mohamed , Ploux Sylvain , de Guillebon Maxime , Dompnier Antoine , Boveda Serge , Gomes-Ferreira Sophie , Giraudeau Cédric , Peyrol Michael , Winum Pierre , Gal Benjamin , Blangy Hugues , Le Vavasseur Olivier , Duparc Alexandre , Forelle Laura , Behaghel Albin , Fouche Renaud , Laurent Gabriel , Barake Hassan , Reuter Sylvain , Sultan Pierre , Da Costa Antoine 
Published: October 2024

Abstract

Aims
Integrating remote monitoring (RM) into existing healthcare practice for heart failure (HF) patients to improve clinical outcome remains challenging. The ECOST-CRT study compared the clinical outcome of a comprehensive RM scheme including a patient questionnaire capturing signs and symptoms of HF and notifications for HF specific parameters to traditional RM in patients with cardiac resynchronization therapy (CRT) devices.

Methods and results
Patients were randomized 1:1 to standard daily RM (notification for technical parameters and ventricular arrhythmias; control group) or comprehensive RM (adding a monthly symptom questionnaire and notifications for biventricular pacing, premature ventricular contraction, atrial arrhythmias; active group). The primary endpoint was all-cause mortality or hospitalization for worsening HF (WHF). Six hundred fifty-two patients (70.4 ± 10.3 years, 73% men, left ventricular ejection fraction 29.1 ± 7.6%, 68% CRT-Defibrillators, 32% CRT-Pacemakers) were enrolled. The COVID-19 pandemic caused an early termination of the study, so the mean follow-up duration was 18 ± 8 months. No statistically significant difference in the primary endpoint was found between the groups [59 (18.3%) control vs. 77 (23.3%) active group; log-rank test P = 0.13]. Among the secondary endpoints, the MLHF questionnaire showed a larger share of patients with improvement of quality of life compared to baseline in the active group (78%) vs. control (61%; P = 0.03).

Conclusion
The study does not support the notion that comprehensive RM, when compared to standard RM, in HF patients with CRT improves the clinical outcome of all-cause mortality or WHF hospitalizations. However, this study was underpowered due to an early termination and further trials are required.

Registration
Clinical Trials.gov Identifier: NCT03012490
MISIP: a data standard for the reuse and reproducibility of any stable isotope probing-derived nucleic acid sequence and experiment
Authors: Simpson Abigayle , Wood-Charlson Elisha M , Smith Montana , Koch Benjamin J , Beilsmith Kathleen , Kimbrel Jeffrey A , Kellom Matthew , Hunter Christopher I , Walls Ramona L , Schriml Lynn M , Wilhelm Roland C 
Published: October 2024

Abstract
DNA/RNA-stable isotope probing (SIP) is a powerful tool to link in situ microbial activity to sequencing data. Every SIP dataset captures distinct information about microbial community metabolism, process rates, and population dynamics, offering valuable insights for a wide range of research questions. Data reuse maximizes the information derived from the labor and resource-intensive SIP approaches. Yet, a review of publicly available SIP sequencing metadata showed that critical information necessary for reproducibility and reuse was often missing. Here, we outline the Minimum Information for any Stable Isotope Probing Sequence (MISIP) according to the Minimum Information for any (x) Sequence (MIxS) framework and include examples of MISIP reporting for common SIP experiments. Our objectives are to expand the capacity of MIxS to accommodate SIP-specific metadata and guide SIP users in metadata collection when planning and reporting an experiment. The MISIP standard requires 5 metadata fields—isotope, isotopolog, isotopolog label, labeling approach, and gradient position—and recommends several fields that represent best practices in acquiring and reporting SIP sequencing data (e.g., gradient density and nucleic acid amount). The standard is intended to be used in concert with other MIxS checklists to comprehensively describe the origin of sequence data, such as for marker genes (MISIP-MIMARKS) or metagenomes (MISIP-MIMS), in combination with metadata required by an environmental extension (e.g., soil). The adoption of the proposed data standard will improve the reuse of any sequence derived from a SIP experiment and, by extension, deepen understanding of in situ biogeochemical processes and microbial ecology.
An anisotropic equation of state for solid solutions, with application to plagioclase
Authors: Myhill R 
Published: October 2024

SUMMARY
This paper presents a framework for building anisotropic equations of state for solid solutions. The framework satisfies the connections between elastic and thermodynamic properties required by Maxwell’s relations. It builds on a recent anisotropic equation of state for pure phases under small deviatoric stresses, adding a dependence on a vector $\boldsymbol {n}$, whose components $n_i$ contain the molar amounts of independent end-members in the solid solution. These end-members may have distinct chemical compositions, site species occupancies or electronic spin states. The high albite-anorthite (C$\bar{\text{1}}$) plagioclase solid solution is used to illustrate the formulation.
A new politics of international criminal justice: accountability in Ukraine and the Israel–Gaza war
Authors: Jacob Cecilia 
Published: October 2024

Abstract
Protecting civilian populations affected by violent conflict and mass atrocities is a challenge in global politics, particularly in view of the persistence of contestation over the application of the Responsibility to Protect principle and geopolitical gridlock in the UN Security Council. Over the past decade, there has been a pronounced rise in international accountability mechanisms to fill protection gaps in the multilateral system. Increasingly, international accountability mechanisms have been activated in the early phases of conflict situations to counter atrocities, promoting protection in ‘real time’. This article proposes that the deepening association between accountability and protection is best understood as an emergent human protection transnational legal order (HPTLO), a mode of decentralized governance that was driven by diverse agency across borders and aimed at solving problems of a global reach through legal ordering. The article provides an account of the formation and character of the HPTLO, demonstrates how it is operating in the context of the wars in Ukraine and Gaza, and identifies key risks and opportunities that these developments present to the global governance of human protection.
TcdB From Hypervirulent Clostridioides difficile Induces Neuronal Loss and Neurotransmitter Alterations in the Intrinsic Enteric Nervous System
Authors: Zhang Kai , Zhou Qi , Gu Hanyang , Yang Ming , Lin Xinghao , Wang Mengjie , Zhai Huaqian , Zhang Feng , Luo Yongneng , Chen Linjie , Wan Shuangshuang , Chen Yu , Chen Wei , Jin Dazhi , Hu Hui 
Published: October 2024

Abstract
Clostridioides difficile infection (CDI) is a predominant cause of intestinal infections. The intrinsic enteric nervous system (ENS) occupies the intestinal tissue in large numbers and intricately regulates various aspects of intestinal function. Nonetheless, the specific effects of CDI on the intrinsic ENS remain underexplored. Herein, we employed the toxin B variant (TcdB2) derived from hypervirulent C difficile to elucidate the impact of CDI on neurons located in colonic wall. We found that TcdB2 directly induced dose-dependent cytopathic effects on enteric neurons both in vitro and in adult mice colons. Notably, an increased expression of choline acetyltransferase and neural nitric oxide synthase in colonic neurons prior to the onset of cytopathic changes following treatment with TcdB2 were observed, both in vivo and in vitro. These findings suggest that during CDI, TcdB not only causes neuronal loss but also alters the composition of neurotransmitters in the ENS.
Outpatient parenteral antimicrobial therapy (OPAT) using a continuous ambulatory delivery device (CADD) allowing treatment with multiple daily doses: a brief report of a Norwegian experience
Authors: Skogen Vegard , Helleren Rita , Jacobsen Marianne Giske , Opsal Anne , Gallefoss Frode 
Published: October 2024

Abstract

Background
Outpatient parenteral antimicrobial therapy (OPAT) is safe, effective and increasingly available. While OPAT in Norwegian healthcare has been rare, a new continuous ambulatory delivery device (CADD) allowing multiple daily dosing treatments has been innovated making OPAT more accessible.

Objectives
To describe the clinical outcome and safety using CADD in an OPAT setting.

Methods
Adult patients in need of parenteral antibiotic treatment were offered OPAT and discharged with a programmable digital infusion pump allowing multiple daily dosings.

Results
Altogether, 170 patients were included in the study, among which 21% of all patients (36 of 170) were readmitted to hospital while receiving OPAT or within 30 days after end of intravenous antibiotics. None of the 170 patients died due to OPAT and allergies were not noticeable as a problem.

Conclusions
We have developed a safe and clinically effective programme offering OPAT in accordance with Norwegian antibiotic treatment guidelines.
Plant stoichiometry in relation to relative growth rate
Authors: Ågren Göran I 
Published: October 2024

Abstract
Plants need certain proportions between elements for proper growth and functioning. These proportions vary with growth conditions and it has generally been found that with increasing relative growth rates P:N should increase (the growth rate hypothesis). However, the proportions between N and other elements change with growth rates, and how this determines which element is limiting growth is not well studied, but it is possible that limitations of other elements could restrain plant growth more than N. Using results from nine studies with birch plants (Betula pendula) with different limiting elements (N, P, K, S, Mg, Zn, Mn, Fe and Cu) under steady-state growth, I have investigated how the switch, defined as the ideal proportion, between which element is limiting growth varies with relative growth rate. The ideal proportion of element:N increases with increasing relative growth rate for K, P, Zn and Mn but a slight decline for Mg and S. The changes in element:N ratios are strongest at low relative growth rates. The consequences of these results for plant properties under global change are discussed.
Stomata: gatekeepers of uptake and defense signaling by green leaf volatiles in maize
Authors: Maleki Feizollah A , Seidl-Adams Irmgard , Felton Gary W , Kersch-Becker Mônica F , Tumlinson James H 
Published: October 2024

Abstract
Plants adapt to balance growth–defense tradeoffs in response to both biotic and abiotic stresses. Green leaf volatiles (GLVs) are released after biotic and abiotic stresses and function as damage-associated signals in plants. Although, GLVs enter plants primarily through stomata, the role of stomatal regulation on the kinetics of GLV uptake remains largely unknown. Here, we illustrate the effect of stomatal closure on the timing and magnitude of GLV uptake. We closed stomata by either exposing maize (Zea mays) plants to darkness or applying abscisic acid, a phytohormone that closes the stomata in light. Then, we exposed maize seedlings to (Z)-3-hexen-1-ol and compared its dynamic uptake under different stomatal conditions. Additionally, we used (E)-3-hexen-1-ol, an isomer of (Z)-3-hexen-1-ol not made by maize, to exclude the role of internal GLVs in our assays. We demonstrate that closed stomata effectively prevent GLV entry into exposed plants, even at high concentrations. Furthermore, our findings indicate that reduced GLV uptake impairs GLV-driven induction of biosynthesis of sesquiterpenes, a group of GLV-inducible secondary metabolites, with or without herbivory. These results elucidate how stomata regulate the perception of GLV signals, thereby dramatically changing the plant responses to herbivory, particularly under water stress or dark conditions.
Molecular characteristics of advanced colorectal cancer and multi-hit PIK3CA mutations
Authors: Yasin Faiza , Sokol Ethan , Vasan Neil , Pavlick Dean C , Huang Richard S P , Pelletier Maureen , Levy Mia Alyce , Pusztai Lajos , Lacy Jill , Zhang Janie Yue , Ross Jeffrey S , Cecchini Michael 
Published: October 2024

Abstract

Introduction
Approximately 20% of patients living with colorectal cancer (CRC) have activating mutations in their tumors in the PIK3CA oncogene. Two or more activating mutations (multi-hit) for the PIK3CA allele increase PI3K⍺ signaling compared to single-point mutations, resulting in exceptional response to PI3K⍺ inhibition. We aimed to identify the prevalence of PIK3CA multi-hit mutations in metastatic CRC to identify patients who may benefit from PI3K inhibitors.

Methods
The Foundation Medicine database (Boston, MA, USA) was analyzed for patients with CRC who underwent genomic profiling on tumor DNA isolated during routine clinical care from 2013 to 2021. Molecular and clinical variables were abstracted for patients with PIK3CA mutations.

Results
We identified 49 051 patients with CRC who underwent Foundation Medicine testing. 710/41154 (1.7%) patients had multi-hit PIK3CA mutations, of which 53% were male (n = 448) with a median age of 60. Microsatellite status was available for 697 patients with multi-hit PIK3CA and 17.6% (123/697) were microsatellite instability-high. Clinically relevant mutations in KRAS and BRAFV600E were seen in 459/710 (64.7%) and 65/710 (9.1%), respectively. The 4 most common PIK3CA variants were H1047R (9.8%), E545K (9.2%), E542K (9.0%), and R88Q (7.1%). The most common variant pair was E542K-E545K (4.7%).

Conclusions
Multi-hit mutations in PIK3CA are seen in 1.7% of advanced CRC, a meaningful prevalence given the high burden of CRC worldwide, and may represent a subset of patients that have enhanced sensitivity to PI3K inhibition. Future investigation regarding the clinical utility of PI3K inhibitors is warranted in multi-hit PIK3CA CRC.
Self-regulated analgesia in males but not females is mediated by endogenous opioids
Authors: Dean Jon G , Reyes Mikaila , Oliva Valeria , Khatib Lora , Riegner Gabriel , Gonzalez Nailea , Posey Grace , Collier Jason , Birenbaum Julia , Chakravarthy Krishnan , Wells Rebecca E , Goodin Burel , Fillingim Roger , Zeidan Fadel 
Published: October 2024

Abstract
Converging lines of preclinical and clinical research indicate that females, in stark contrast to males, display an increased prevalence of chronic pain. Females also demonstrate weaker analgesic efficacy in response to opioid therapies when compared with males. These sex-specific differences may be driven by dimorphic endogenous opioidergic responses. In rodent models, analgesia exhibited in males but not females was reversed by inhibiting endogenous opioidergic reception. In humans, the sex-specific endogenous system(s) supporting the direct attenuation of evoked pain has not been identified. To determine whether opioidergic blockade reverses self-regulated analgesia in males as compared to females, the present study combined two operationally analogous clinical trials (n = 98; 51 females and 47 males). In a double-blinded, counterbalanced study involving healthy (n = 39) and chronic low back pain (n = 59) populations, a high-dose naloxone (μ-, κ-, δ-opioid antagonist) vs. placebo-saline cross-over design (15 mg/kg bolus +0.1 mg/kg/h) tested the hypothesis that endogenous opioids mediate analgesia in males but not females. An 11-point visual analog scale (VAS) (0 = no pain; 10 = worst pain imaginable) evaluated pain ratings in response to noxious heat stimulation (49 °C; calf). After baseline pain testing, participants were randomized to a validated four-session mindfulness meditation or sham mindfulness meditation training intervention. Participants practiced their respective meditation during noxious heat, intravenous high-dose naloxone, and placebo saline, respectively. In males and females, meditation significantly lowered evoked pain during saline infusion. Intravenous naloxone inhibited analgesia in males, but pain relief was well preserved in females. The present findings indicate that endogenous opioids mediate self-regulated analgesia in males but not females and underscore the need to establish sex-specific pain therapeutics.
Overinference from Weak Signals and Underinference from Strong Signals
Authors: Augenblick Ned , Lazarus Eben , Thaler Michael 
Published: October 2024

Abstract
When people receive new information, sometimes they revise their beliefs too much, and sometimes too little. We show that a key driver of whether people overinfer or underinfer is the strength of the information. Based on a model in which people know which direction to update in, but not exactly how much to update, we hypothesize that people will overinfer from weak signals and underinfer from strong signals. We then test this hypothesis across four different environments: abstract experiments, a naturalistic experiment, sports betting markets, and financial markets. In each environment, our consistent and robust finding is overinference from weak signals and underinference from strong signals. Our framework and findings can help harmonize apparently contradictory results from the experimental and empirical literatures.
Don’t go with the flow: cranial adaptations of stream tadpoles in the Afrobatrachian family Arthroleptidae
Authors: Schweiger Susan , Rödel Mark-Oliver , Hammel Jörg U , Müller Hendrik 
Published: October 2024

Abstract
Arthroleptidae are an ecologically diverse group of sub-Saharan frogs. Arthroleptid tadpoles predominately occur in slow flowing to torrent waters. Their musculoskeletal system and the relationship between tadpole morphology and lifestyle are poorly understood. Here, we investigated the cranial morphology of four arthroleptid tadpoles occurring in different microhabitats: Leptopelis parkeri, Astylosternus occidentalis, Trichobatrachus robustus, and Nyctibates corrugatus. The crania of the tadpoles of A. occidentalis, N. corrugatus, and T. robustus are highly modified relative to L. parkeri, with wide and partly or completely fused cornua trabeculae, a fused cartilago labialis superior, as well as several modifications of the palatoquadrate, such as a broad commissura quadratocranialis and a processus ventralis which expands the surface for the origin of the large m. orbitohyoideus. The processus hyoquadratis is an evolutionary novelty, forming a functional unit together with the ceratohyale in the cranium of N. corrugatus. Finally, we compared the cranial morphology of these arthroleptids to other lotic and non-lotic species. Although the processus ventralis is not a generalized feature of the cranium in lotic species, it is not present in lentic species.
A Collaborative Online International Learning Experience for Doctoral Nursing Students and Faculty From Three Countries: Reshaping the Educational Landscape
Authors: Cornelius Judith Bacchus , Downing Charlene , Ogunfowokan Adesola A. , Ntshingila Nompumelelo , Okoro Florence , Enweana Ijeoma , Olagunju Oluwayemisi 
Published: October 2024

Abstract
The COVID-19 pandemic presented opportunities for educational innovations and the development of intercultural learning experiences. A global health assignment guided by a collaborative online international learning pedagogy was assigned to doctoral nursing students from three different countries. Icebreaker activities, along with the Culturally You diagram, commenced the team-building process. Students, mentored by course faculty, completed the assignment, a 10-minute presentation and reflections. Positive trends in intercultural sensitivity scores were observed, highlighting exposure to a new teaching platform, global health issues, and the value of faculty mentorship. While challenges existed, successful collaborations could thrive even during a pandemic.
Leadership Behaviors That Impact Nurse Faculty Job Satisfaction: A Qualitative Descriptive Study
Authors: Heier Cori , Busenhart Cara A. , Park Shin Hye , Sanner-Stiehr Ericka , Brooks Joanna , Nelson-Brantley Heather 
Published: October 2024

Abstract

AIM
The aim of the study was to identify specific actionable behaviors academic nurse leaders can implement to improve nurse faculty job satisfaction.

BACKGROUND
The nurse faculty shortage is a persistent and worsening problem, with job dissatisfaction a significant contributor in the United States. However, little is known about actionable behaviors academic nurse leaders can do to improve nurse faculty job satisfaction.

METHOD
Qualitative semistructured interviews were conducted with 15 nurse faculty. Inductive thematic analysis was used to analyze and interpret the interviews.

RESULTS
Four themes emerged about academic nurse leader behavior: 1) build relationships with leaders and faculty, 2) create an environment where autonomy is valued, 3) facilitate faculty growth and development, and 4) serve as a role model.

CONCLUSION
Effective leadership contributes to nurse faculty job satisfaction. Academic nurse leaders need to be aware of their influential behaviors and intentionally contribute to creating a workplace environment that promotes nurse faculty job satisfaction.
Hereditary angioedema due to C1-inhibitor deficiency: current therapeutic approaches
Authors: Costanzo Giulia , Sambugaro Giada , Firinu Davide 
Published: October 2024

Purpose of review
For decades, treatment options for hereditary angioedema (HAE) were limited by major adverse effects, insufficient efficacy, and difficult routes of administration. However, the growing body of knowledge regarding HAE pathophysiology has led to the development of innovative drugs for self-administered, on-demand therapy and for short- and long-term prophylaxis. This review provides a comprehensive overview of the approved drugs and the development of HAE treatments.

Recent findings
The implementation of new therapies will improve the application of individualized action plans based on the key goals of minimizing the number of attacks and meeting the complex needs of patients.

Summary
HAE is a rare genetic disease with a high impact on patients’ quality of life due to the unpredictability and variable severity of attacks. Advances in HAE research have allowed optimization of attack management and individualization of therapeutic approaches.