bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-reported Strategies for Prevention and Treatment of Chemotherapy- induced Peripheral Neuropathy
Authors: Hertz Daniel L , Tanay Mary , Tofthagen Cindy , Rossi Emanuela , Bernasconi Davide Paolo , Sheffield Katharine E , Carlson Martha , Nekhlyudov Larissa , Grech Lisa , Von Ah Diane , Mayo Samantha J , Ruddy Kathryn J , Chan Alexandre , Alberti Paola , Lustberg Maryam B 
Published: October 2024

Abstract

Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating toxicity of many drugs used in cancer treatment. There are numerous available strategies for preventing or treating CIPN, but few are guideline-recommended, due to limited evidence of their effectiveness. The primary objective of this survey was to understand what strategies patients used to prevent or treat CIPN, and to understand their perceptions around CIPN prevention and treatment.
Methods: The Multinational Association of Supportive Care in Cancer (MASCC) Neurological Complications Study Group created a cross-sectional online survey to recruit individuals who are currently or had previously received neurotoxic chemotherapy treatment and self-reported peripheral neuropathy. Descriptive statistics were reported.
Results: Most of the 447 survey participants did not use any CIPN prevention strategy (71%), though given options of any strategy the plurality preferred a prescribed medication or supplement (30%). The most common treatment strategy used was exercise (47%), with some patients trying prescription medications including non-guideline recommended gabapentin (33%) or guideline-recommended duloxetine (8%) options. Nearly half of participants (49%) used at least one non-prescribed medication for treating CIPN. Patient’s often followed suggestions of their medical oncology clinical team, but sometimes relied on the internet or other patients to recommend non-prescription strategies.
Conclusion: In the absence of many guideline-recommended strategies for CIPN prevention and treatment, some patients use options with minimal evidence of effectiveness. Additional research is needed to determine which strategies are effective for prevention and treatment so these can be implemented in practice to improve treatment outcomes in patients with cancer.
Psychological Impact of the 2023 Kahramanmaraş Earthquakes on Non-Victims
Authors: Çınaroğlu Metin , Yılmazer Eda , Alpugan Zeynep , Sayar Gökben Hızlı 
Published: October 2024

Abstract

The 2023 Kahramanmaraş earthquakes, with magnitudes of 7.7 and 7.6, caused extensive destruction and psychological distress across southeastern Turkey. This study explores the psychological impact on non-victims, particularly Istanbul residents, focusing on mental health outcomes and coping mechanisms. A cross-sectional survey was conducted from March to May 2024 with 721 participants from various Turkish cities, including a significant portion from Istanbul. Validated psychological scales such as the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Warwick-Edinburgh Mental Well-being Scale (WEMWBS), and PTSD Checklist for DSM-5 (PCL-5) measured depression, anxiety, well-being, and PTSD symptoms. Sociodemographic factors like age, gender, occupation, income, education level, and previous earthquake experience were also analyzed.
Results showed significant psychological distress among non-victims: 51.9% reported high levels of distress, with 24% meeting PTSD criteria, 30% exhibiting moderate to severe depression, and 28% experiencing significant anxiety. Higher income and education levels correlated with better mental health outcomes. Higher education levels were linked to lower PTSD risk (β = -0.20, p < 0.01) and fewer depression symptoms (β = -0.15, p < 0.05). Higher income was associated with lower depression scores (β = -0.20, p < 0.01) and fewer PTSD symptoms (β = -0.15, p < 0.05). Age positively correlated with well-being (r = 0.68, p < 0.001) and negatively with PTSD symptoms (r = -0.15, p < 0.05).
Comparisons with victim studies of major earthquakes, such as the 1995 Great Hanshin-Awaji earthquake, the 1999 Marmara earthquake, the 2008 Wenchuan earthquake, and the 2000 Iceland earthquakes, revealed similar profound psychological impacts. This highlights the need for comprehensive mental health interventions for both direct and indirect exposures. This study underscores the necessity for inclusive mental health strategies to enhance resilience and well-being, ensuring robust recovery after catastrophic events.
The relationship between depression and alcohol use among the Wa ethnic minority in China
Authors: Yang Wanqiu , Young Allan , Liu Junjun , Gaffney Jess Kerr , Jauhar Sameer , Leng Dan , Li Chaoxiao , Li Kunjie , Pu Yongjie , Yang Borui , Wang Yanqing , Zhang Xingang 
Published: October 2024

Abstract

Background
Alcohol use and depression often co-occur; however, little is known about this association with specific ethnic groups. This study aimed to explore the relationship between alcohol use and depression in the Wa ethnic group in China.
Methods
A stage sampling method was utilized to survey respondents from the Wa ethnic group, who have transitioned rapidly from traditional slash-and-burn cultivation to modern societies. The Alcohol Use Disorder Identification Test (AUDIT) and the Patient Health Questionnaire-9 (PHQ-9) to assess their alcohol use and depressive symptoms, respectively. Data were analyzed using generalized additive models and a two-segment logistic regression.
Results
Among the 668 participants, 48.98% (337/668) were current drinkers. Low-risk, high-risk, and probable alcohol-dependence drinkers accounted for 21.4%, 25.4%, and 2.7% of the sample, respectively. Generalized additive models revealed a non-linear association between AUDIT scores and depressive symptoms, with a statistically significant non-linearity (P < 0.001). A-segment logistic regression identified a critical point at an AUDIT of 15. this threshold, each increase in AUDIT score led to a notable 43% increase in the likelihood of experiencing depressive symptoms (OR = 143, 95 CI: 119,1.72, < 0.). while, on the lower end of the threshold, there was no significant association between the AUDIT score and depressive symptoms observed (OR 0.98 95% CI 0.90, 1.05, P = 0.53).
Conclusion
A non-linear relationship between alcohol use and depression was identified in the Wa ethnic group, suggesting a threshold effect. Screening for alcohol use could help identify individuals at risk of depression in ethnic populations.
Diffusion tensor image analysis along the perivascular space in former professional athletes with repetitive mild traumatic brain injury history
Authors: Miyata Mari , Kamagata Koji , Saito Yuya , Uchida Wataru , Takabayashi Kaito , Moriguchi Sho , Momota Yuki , Ichihashi Masanori , Kurose Shin , Endo Hironobu , Tagai Kenji , Kataoka Yuko , Mimura Masaru , Aoki Shigeki , Higuchi Makoto , Takahata Keisuke 
Published: October 2024

Abstract

The long-term changes in the glymphatic system of former professional athletes exposed to repetitive mild traumatic brain injuries remain poorly understood. This study aimed to use diffusion tensor image analysis along the perivascular space (DTI-ALPS) to evaluate the glymphatic system activity and correlate the ALPS-index with neuropsychiatric symptoms in former professional athletes. Thirty former professional athletes and 24 age- and sex-matched controls underwent DTI with 3T magnetic resonance imaging. The ALPS-index (mean, right, and left) in the athlete group was compared with that in controls, and correlations with clinical variables were analyzed. The mean, right, and left ALPS indices in the athlete group were significantly lower than those of the control group (mean: 1.49±0.12 vs. 1.61±0.16, p<0.01; right: 1.51±0.12 vs. 1.61±0.16, p=0.01; and left: 1.47±0.15 vs. 1.60±0.20, p<0.01). The mean and right ALPS indices were positively correlated with the Wisconsin Card Sorting Test performance in the athlete group (mean: r=0.41, p=0.04; right: r=0.43, p=0.03; not significant after Bonferroni correction). In conclusion, a lower ALPS-index in former professional athletes may be associated with impairments in cognitive function, reflected in glymphatic dysfunction.
The Impact of Posterior Root Tears of the Medial Meniscus on Meniscal Extrusion and Cartilage Degeneration
Authors: Zhou Yongwei , He Shan , Kang Jiayu , Yang Qining 
Published: October 2024

Abstract

Background: To explore the impact of the severity of the tear gap caused by medial meniscus posterior root (MMPR) tear on medial meniscus extrusion and bone cartilage based on magnetic resonance imaging (MRI).
Methods: A retrospective analysis was conducted on 153 patients with medial meniscus root tear who were admitted to Jinhua Central Hospital from January 1, 2020, to October 31, 2023. According to the size of the tear gap, they were divided into mild displacement (M) group (≤4mm) and extensive displacement (W) group (>4mm). The M group consisted of 73 cases (70 females, 3 males), aged 52-63 years (mean age 56 years); the W group consisted of 80 cases (75 females, 5 males), aged 55-65 years (mean age 57.5 years). There was no significant difference in age and gender between the two groups (P>0.05). The distances of medial meniscus extrusion and bone cartilage injury in the two groups were compared and analyzed.
Results: In the M group, the average extrusion distance of the medial meniscus was 3.5mm (1.5-5mm), and in the W group, the average extrusion distance of the medial meniscus was 4.53mm (2.5-7.3mm). The comparison between the two groups was statistically significant (P<0.05). The degree of femoral medial condyle cartilage degeneration was more severe in the W group, which was statistically significant compared with the M group (P<0.05). In the W group, bone hyperplasia, subchondral cyst formation, and narrowing of the medial compartment were more common, but there was no significant difference compared to the M group (P>0.05).
Conclusion: The size of the tear gap caused by medial meniscus root tear on MRI is an important risk factor for medial meniscus extrusion and bone cartilage degeneration, which can provide a good idea for predicting the progression of osteoarthritis clinically.
Education with mobile App and educational website in the metabolic control of patients with type 2 diabetes. Protocol study of a Multicenter Clinical Trial
Authors: López Lubia Velázquez , Klünder Miguel Klünder , Gil Jenny Vilchis , Peña Jorge Escobedo de la , Aguila Ignacio Pineda del , Gómez Oswaldo Sinoe Medina 
Published: October 2024

Abstract

Background: Diabetes education is a fundamental pillar for accomplishing metabolic control, improving knowledge about the disease and the lifestyle in the patient with diabetes. The benefit of mHealth has been shown to be an important tool for monitoring, disease care and lifestyle improvement in patients with type 2 diabetes (T2D). In less developed countries, the effect of educational intervention through mHealth is still inconclusive. The objective of this study is to evaluate the effect of an intervention on the metabolic control of the patient with T2D with mHealth intervention and educational website called "I understand my diabetes".
Methods. The study is designed as a randomized controlled trial with a parallel-group design. The total study duration is 12 months with data collection at baseline, 3, 6, 9 and 12 months. We plan to include 480 Mexican adult patients with T2D. Participants will be randomized to one of three interventions: (1) Group with Web education program (2) Group web education program+ mobile App for diet and exercise plan (1) Usual care intervention. The primary outcome is changes in glycated hemoglobin A1c. Other outcome measures include changes in Lipid profile, body composition and anthropometric measurements, quality of life, lifestyle and physical activity.
Discussion: The study has a 12-month follow-up of intervention and will provide knowledge and results of the effect of the use of a mobile app and educational website on the metabolic control of patients with diabetes. The results may be relevant for implementation in public institutions with high demand of patients with type 2 diabetes without severe complications of the disease. Interventions with diabetes education and reinforcement with the healthcare professional with the use of mHealth may be strategies to achieve and maintain metabolic control and disease care in patients with diabetes.
Trial registration number: Clinical Trials.gov. Registry (NCT0627857I). The protocol number: Effect of Education with Mobile App on metabolic control in Patients With type 2 Diabetes. The registration number R-2018-785-100. Instituto Mexicano del Seguro Social. Mexico. Registration date: february 22, 2024.
Clinical and Epidemiological Characteristics of Chikungunya and Dengue Infections in Provincial Hospitals of Davao de Oro, Philippines
Authors: Arce Nestor , Boonak Kobporn , Bernasor Lee Thunder , Salas Christian Joy , Putri Anastasia , Aung Pyae Linn , Imad Hisham Ahmed , Chierakul Wirongrong , Luvira Viravarn , Phonrat Benjaluck , Phumratanaprapin Weerapong , Charunwatthana Prakaykaew 
Published: October 2024

Abstract

Mosquito-borne diseases like dengue and chikungunya are endemic in the tropical region and is a common cause of acute febrile illness in both adults and children. The Philippines, home to over a hundred million residents and visited by several million tourists each year, is one such region where the risk of these diseases is endemic. To better understand the detailed situation, we estimated the proportion of these diseases in the community by conducting a prospective observational study conducted in four provincial hospitals of Davao de Oro, Philippines from February 2019 to February 2020. Serum from 382 study participant was used for laboratory confirmation of dengue or chikungunya either by antigen, antibody or by RT-PCR. Dengue was diagnosed in 57.1%, chikungunya 7.07%, co-infection with both dengue and chikungunya in 7.3%, and the etiology was undetermined in 35.9% of study participants. Common clinical symptoms included fever, headache, and rash, which were overlapping symptoms and clinically indistinguishable at presentation to the hospital, necessitating the need for laboratory diagnostics. The identification of the presence of chikungunya in Davao de Oro calls for increased awareness, improved diagnostics, and integrated disease control measures to manage outbreaks that can occur in dengue endemic regions.
Patient perspectives on health care models in cardiac surgery: A qualiative evaluation
Authors: Schmid Mona Elisabeth , Stumm Jannik , Stock Sina , Girdauskas Evaldas 
Published: October 2024

Abstract

Background
The implementation of ERAS represents a promising solution to improve treatment efficiency and facilitate patient involvement. This innovative care model aims to optimize recovery processes following surgeries by adopting a holistic, interprofessional approach. At our hospital, ERAS was implemented in minimally invasive heart valve surgery, offering two distinct ERAS models. Additionally, there is also the standard of care without ERAS. The objective of the study is to gain insight into patient satisfaction and perceived differences across these various care models.
Methods
Patients were interviewed using semi-structured interviews approximately two to three months after undergoing surgery. The data were analysed using qualitative content analysis in accordance with the methodology proposed by Kuckartz. Four main categories were established: Preoperative care, postoperative care and communication, patient participation and involvement, and rehabilitation and post-clinical course.
Results
Comprehensive preoperative education and seamless communication throughout the perioperative care journey were identified as fundamental to patient satisfaction and optimal care processes. Patients in the ERAS + model reported higher overall satisfaction with their care compared to patients in the standard of care and ERAS groups.
Conclusion
Preoperative education establishes the foundation for patients' subsequent behaviours and expectations regarding their treatment. Aspects such as physical activity, nutrition, and mental health are of significant importance. The active involvement and participation of patients and their families in the treatment process facilitated superior postoperative care, intensive physiotherapy, mental support, and faster recovery. A functional flow of information throughout the entire care process is of utmost importance. Moreover, having a dedicated point of contact had a beneficial impact on patients´ well-being. The integration of innovative ERAS concepts, which encompass interprofessional preoperative patient education and psychosomatic support, represents a promising approach from a patient perspective, offering benefits to a broad spectrum of cardiac surgical patients.
Assessing Healthcare Cost Changes Associated with Transitioning away from Cigarette Smoking Using Healthcare Claims Data: an Exploratory Study among Adult Male Patients with COPD
Authors: Zhang Mingda , Cheng Hui G. , Noggle Brendan , Janak Jud C. , Richards Megan , Smith David 
Published: October 2024

Abstract

Background: The assessment of potential health effects of switching from cigarette smoking to non-combustible tobacco products has important implications for public health and regulatory decisions. Robust epidemiological evidence requires long-term follow-up of a large number of individuals. Real-world evidence derived from health records has the potential to help fill the gap in the interim. To our knowledge, this is the first study using individual-level healthcare claims data to assess the potential impact of transitioning from cigarette smoking to smokeless tobacco on short-term direct healthcare costs.
Methods: We conducted a retrospective cohort study of adult male patients with COPD who smoked cigarettes at baseline using the MarketScan® Databases. We compared changes in direct healthcare costs between the 12-month periods before (baseline) and after the index date (follow-up) across three cohorts: continued smoking (CS), quit all tobacco (QT), or switched to smokeless tobacco (SW), using a non-linear difference-in-differences model with average marginal effects.
Results: A total of 23,427 COPD patients were included (CS: 11,167; QT: 12,013; SW: 247). At baseline, the QT cohort had the highest total average healthcare costs ($43,771), followed by SW ($38,419), and CS ($27,149). The unadjusted difference-in-differences model revealed no statistically significant differences in total healthcare cost changes when comparing the QT or SW cohorts to the CS cohort (-$1,532 [95% CI: -$3,671, $608] for the QT cohort, and -$452 [95% CI: -$15,415, $14,511] for the SW cohort). After adjusting for Deyo-Charlson Comorbidity Index and COPD exacerbation, the QT cohort had greater reduction in total healthcare costs compared to the CS cohort (-$2,910 dollars [95% CI: -$4,485, $-1,335]) assuming a two-unit increase in comorbidities and COPD exacerbations. The same trend was observed for the SW cohort, although the estimate was not statistically significant (-$5,312 [95%CI: -$11,067, $442], p=0.08).
Conclusions: This study demonstrated the feasibility of using administrative claims to conduct real-world evidence studies on the harm-reduction potential of non-combustible tobacco products and found evidence suggesting reductions in direct healthcare costs after quitting tobacco or switching to smokeless tobacco among patients with COPD. Based on the learnings and limitations identified during the study, we propose concrete recommendations to improve future observational studies by integrating additional real-world healthcare data from multiple data sources.
Regulation of ROS metabolism in macrophage via xanthine oxidase is associated with disease progression in pulmonary tuberculosis
Authors: Liu Ruichao , Zhang Fuzhen , Liu Qiuyue , Pang Yu , Li Liang 
Published: October 2024

Abstract

Backgrond Pulmonary tuberculosis (PTB) exacerbation can lead to respiratory failure, multi-organ failure, and symptoms related to central nervous system diseases. The purpose of this study is to screen biomarkers and metabolic pathways that can predict the progression of pulmonary tuberculosis, and to verify the role of the metabolic enzyme xanthine oxidase in the progression of PTB. Methods To explore the biomarkers and mechanisms underlying the progression of PTB, plasma metabolomics sequencing was conducted on patients with severe PTB, non-severe PTB, and healthy individuals. Screening differential metabolites and metabolic pathways that can predict the progression of pulmonary tuberculosis, and verifying the function and mechanism of action of XO through experiments. Results The purine metabolism, sphingolipid metabolism, and amino acid metabolism between the three groups differ. In patients with severe PTB, the levels of xanthosine and hypoxanthine are increased, while the levels of D-tryptophan, dihydroceramide and uric acid are decreased. Inhibition of XO activity has been observed to reduce the expression levels of tumor necrosis factor (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), as well as to suppress the production of reactive oxygen species (ROS) and the activation of the NF-κB pathway, while also promoting the growth ofMTB within cells. Conclusion D-tryptophan, xanthosine, and dihydroceramide can be utilized as biomarkers for progression of PTB, assisting in the evaluation of disease progression, and XO stands out as a potential therapeutic target for impeding the progression of PTB.
Revision Total Hip Arthroplasty with Medial Wall Defect using Bone Graft with or without Porous Metal Restrictor
Authors: Do Min Uk , Kang Sang Woo , Lee Sang-Min , Kim Jae Jin , Suh Kuen Tak , Shin Won Chul 
Published: October 2024

Abstract

We aimed to evaluate whether there were differences in outcomes of revision total hip arthroplasty (THA) with acetabular medial wall defects depending on the use of trabecular metal (TM) augmentation. Between 2009–2021, 130 patients were classified into two groups: 80 patients undergoing only bone grafting (BG group) and 50 patients undergoing both bone grafting and TM augmentation (BG/TM group). We evaluated the postoperative center of rotation (COR) position and changes in vertical and horizontal COR at last follow-up. Additionally, we categorized the fate of the transplanted bone graft into four groups: unchanged, initially changed, resorption-no further intervention, and resorption-revision. The mean horizontal COR changes were − 3.50 mm in the BG group and − 1.07 mm in the BG/TM group (p = 0.005). In the BG/TM group, a higher proportion of the patients showed unchanged or only initial changes when compared to the BG group (88.0% and 65.0%, respectively). The BG/TM group showed more favorable results regarding horizontal changes in the COR and fate of the bone graft. Therefore, for revision THA in patients with severe medial wall defects, the combined use of bone graft and TM augmentation can be a suitable option.