bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence rate of recurrent cardiovascular events in patients with radiographic axial spondyloarthritis and the effect of tumor necrosis factor inhibitors
Authors: Kwon Oh Chan , Lee Hye Sun , Jeon So Young , Park Min-Chan 
Published: October 2024

Abstract
Background
Patients with radiographic axial spondyloarthritis (r-axSpA) are at increased risk of incident cardiovascular events. Tumor necrosis factor inhibitors (TNFi) have shown a protective effect against incident cardiovacular events. However, the incidence of recurrent cardiovascular events in patients with r-axSpA with a history of cardiovascular events, and the effect of TNFi on recurrent cardiovascular events remain unclear. We aimed to assess the incidence rate of recurrent cardiovascular events in patients with r-axSpA with a history of cardiovascular events and evaluate the effect of TNFi on the risk of recurrent cardiovascular events.

Methods
This nationwide cohort study used data from the Korean National Claims Database. Data of patients with r-axSpA who had a history of cardiovascular events after being diagnosed with r-axSpA were extracted from the database. The outcome of interest was the recurrence of cardiovascular events (myocardial infarction or stroke). Patients were followed from the index date (date of the first cardiovascular event) to the date of cardiovascular event recurrence, the last date with claims data, or December 31, 2021, whichever occured first. The incidence rate of recurrent cardiovascular events was calculated. An inverse probability weighted Cox model was used to assess the effect of TNFi exposure on the risk of recurrent cardiovascular events.

Results
This study included 413 patients (TNFi non-exposure, n = 338; TNFi exposure, n = 75). The incidence rate of recurrent cardiovascular events was 32 (95% confidence interval [CI] 22–42) per 1,000 person-years (TNFi non-exposure, 36 [95% CI 24–48] per 1,000 person-years; TNFi exposure, 19 [95% CI 2–35] per 1,000 person-years). In the inverse probability weighted Cox model, TNFi exposure was significantly associated with a lower risk of recurrent cardiovascular events (hazard ratio 0.33, 95% CI 0.12–0.94).

Conclusions
The incidence rate of recurrent cardiovascular events in patients with r-axSpA is substantial. TNFi exposure was associated with a lower risk of recurrent cardiovascular events.
Assessing the dynamic vitality of public spaces in tourism-oriented traditional villages: a collaborative active perception method
Authors: Liu Sheng , Zhu Zhenni , Gao Yichen , Wang Shanshan 
Published: October 2024

Abstract
Public spaces in traditional villages are the root of the development, preservation, and inheritance of rural cultural heritage. However, these spaces in tourism-oriented traditional villages continue to suffer from issues such as inconsistent vitality, more competition than cooperation, and inefficient revitalisation. Limited by the low precision of spatiotemporal data in rural areas, previous static and materialised vitality evaluation methods have failed to explore the dynamic nature of the flow of people in traditional village public spaces. This study investigated a collaborative active perception method using Wi-Fi probes and static snapshots to assess their dynamic vitality. An empirical study was conducted using Yantou Village in Lishui City, China, as an example. The empirical results indicate that this method can qualitatively and quantitatively analyze the spatiotemporal variations and the scenarios of the dynamic vitality of small public spaces in traditional villages, deepening the cognitive depth of their vitality from time and humanity, providing a basis for the spatiotemporal synergistic enhancement of their public spaces, and offering insights for their revitalisation.
Enhancing resilience in complex energy systems through real-time anomaly detection: a systematic literature review
Authors: Aghazadeh Ardebili Ali , Hasidi Oussama , Bendaouia Ahmed , Khalil Adem , Khalil Sabri , Luceri Dalila , Longo Antonella , Abdelwahed El Hassan , Qassimi Sara , Ficarella Antonio 
Published: October 2024

AbstractAs real-time data sources expand, the need for detecting anomalies in streaming data becomes increasingly critical for cutting edge data-driven applications. Real-time anomaly detection faces various challenges, requiring automated systems that adapt continuously to evolving data patterns due to the impracticality of human intervention. This study focuses on energy systems (ES), critical infrastructures vulnerable to disruptions from natural disasters, cyber attacks, equipment failures, or human errors, leading to power outages, financial losses, and risks to other sectors. Early anomaly detection ensures energy supply continuity, minimizing disruption impacts, an enhancing system resilience against cyber threats. A systematic literature review (SLR) is conducted to answer 5 essential research questions in anomaly detection due to the lack of standardized knowledge and the rapid evolution of emerging technologies replacing conventional methods. A detailed review of selected literature, extracting insights and synthesizing results has been conducted in order to explore anomaly types that can be detected using Machine Learning algorithms in the scope of Energy Systems, the factors influencing this detection success, the deployment algorithms and security measurement to take in to consideration. This paper provides a comprehensive review and listing of advanced machine learning models, methods to enhance detection performance, methodologies, tools, and enabling technologies for real-time implementation. Furthermore, the study outlines future research directions to improve anomaly detection in smart energy systems.
ESG and climate-related risks versus traditional risks in commercial banking: A bibliometric and thematic review
Authors: Korzeb Zbigniew , Niedziółka Paweł , Szpilko Danuta , di Pietro Filippo 
Published: October 2024

AbstractThe aim of this study is to classify scientific research on the impact of ESG and climate-related risks on the conduct of the banking business. The systematic literature review was based on a bibliometric analysis of articles found in the Scopus and Web of Science databases. The search was confined to materials published between 2000 and August 2023. After applying criteria limiting the search, the final result was 869 unique literature items which were later analysed towards establishing the relationship of ESG and climate-related risks (‘new banking risks’) with other (so-called ‘traditional’) banking risks and identifying research gaps at the interface between traditional and new banking risks. This article introduces a variety of findings, including the most productive authors, organisations, countries and journals, the most cited articles and keyword distribution. In addition, a map of the evolution of the approach to ESG risk in banking was constructed on the basis of the literature review. The study identified 11 clusters of banking risk influenced by ESG risk and 10 clusters of banking risk affected by climate-related risk.
INTEGRATE IIa Phase III Study: Regorafenib for Refractory Advanced Gastric Cancer
Authors: Pavlakis Nick , Shitara Kohei , Sjoquist Katrin , Martin Andrew , Jaworski Anthony , Tebbutt Niall , Bang Yung-Jue , Alcindor Thierry , O'Callaghan Chris , Strickland Andrew , Rha Sun Young , Lee Keun-Wook , Kim Jin-Soo , Bai Li-Yuan , Hara Hiroki , Oh Do-Youn , Yip Sonia , Zalcberg John , Price Tim , Simes John , Goldstein David 
Published: October 2024

PURPOSE
Treatment options for refractory advanced gastric and esophagogastric junction cancer (AGOC) are limited. Regorafenib, an oral multikinase inhibitor, prolonged progression-free survival (PFS) versus placebo in the INTEGRATE I phase II trial. INTEGRATE IIa was designed to examine whether regorafenib improved overall survival (OS).

METHODS

A double-blind placebo-controlled phase III trial compared regorafenib and best supportive care (BSC) versus placebo and BSC for participants with confirmed evaluable metastatic/advanced AGOC who failed ≥two prior therapies on a 2:1 random assignment, stratified by tumor location, geographic region (Asia
v
rest of world), and prior vascular endothelial growth factor inhibitors. The primary end point was OS. Treatment efficacy on OS was first tested in the pooled INTEGRATE I + INTEGRATE IIa cohort and, if significant, then in the INTEGRATE IIa cohort. Secondary end points were PFS, objective response rate, safety, and quality of life (QoL).

RESULTS

INTEGRATE IIa enrolled 251 participants: 157 from Asia and 94 from rest of world and 169 received regorafenib and 82 received placebo. No significant heterogeneity was observed between INTEGRATE I and INTEGRATE IIa studies on OS. Pooled OS analysis hazard ratio (HR) was 0.70 (95% CI, 0.56 to 0.87;
P
= .001; 361 events). INTEGRATE IIa alone OS HR was 0.68 (95% CI, 0.52 to 0.90;
P
= .006; 238 events), the median OS was 4.5 months versus 4.0 months, and 12-month survival rates were 19% and 6%, for regorafenib versus placebo, respectively. After a preplanned adjustment for multiplicity, there were no statistically significant differences across regions or other prespecified subgroups. Regorafenib improved PFS (HR, 0.53 [95% CI, 0.40 to 0.70];
P
< .0001) and delayed deterioration in global QoL (HR, 0.68 [95% CI, 0.52 to 0.89];
P
= .0043). The toxicity profile was consistent with that of previous reports.

CONCLUSION
Regorafenib improves survival compared with placebo in refractory AGOC.
Efficiency of the treatment of epilepsy in adolescent children according to indicators of evoked potentials
Authors: Gekova M. , Tantsura L. 
Published: October 2024

The aim: to identify the peculiarities of the indicators of evoked potentials in epileptic children against the background of anticonvulsant treatment. Methods: auditory long-latency, visual flash-evoked potentials. Epileptic children were divided into two groups. The first group received monotherapy, the second group received polytherapy. Results: The study of average values of latencies showed that children with polytherapy had a more pronounced lengthening of latencies compared to those of the first group. According to the latencies analysis in the group of monotherapeutic children there were no ties between various anticonvulsant drugs and results of examination. There was a tendency towards normalization of latencies, mainly for visual evoked potentials in the group of children with a positive response to treatment. Conclusion: It is advisable to use the method of evoked potentials to assess the functional state of sensory systems in children with epilepsy, in order to predict the course of the disease and assess the effectiveness of treatment.
Orthoses and other conservative methods in hallux valgus
Authors: Pawłowski Bartosz , Madej Aleksandra , Haczkur-Pawłowska Karolina , Kowal Alicja , Jasiński Kacper , Kuzio Agnieszka , Cieplińska Aleksandra , Ziojła-Lisowska Kinga , Gawłowicz Łukasz 
Published: October 2024

Introduction and objective: Hallux valgus is a common deformity (about 23%) in adult population. Deformation of the fist ray and pain causes gait pattern changes and lower life satisfaction. There are many suggestions how to treat bunion. The method of first choice is conservative treatment. One of the most popular option are orthoses of different kinds and functions. The aim of this article is to review the conservative methods of treatment and orthotic management of bunionsand its effectiveness.

Materials and methods: PubMed and Google Scholar databases were searched. The criteria for qualifying the articles for the review were the following keywords: bunion, hallux valgus, orthoses, foot deformity. 21 articles from 2018 to 2023 were analyzed.

Description of the state of knowledge: Conservative treatment includes orthoses, shoe modification, analgesics, and exercises. But the most popular are the first two methods. There are many types of orthoses used for hallux valgus, i.e. dynamic and static orthoses, separators, insoles and splints. Orthoses are used to reduce hallux valgus angle (HVA) and pain, and inhibit the progression of deformity in a long term. Studies show that dynamic orthoses have a greater effect on reducing HVA and pain compared to static orthoses. In addition, they are more frequently and willingly chosen by patients. Also, toe separators have a significant impact on minimizing pain and improving toe alignment.

Summary: Significant reduction of pain and HVA are observed in both short-term and long-term effects when using dynamic orthoses and toe separators. Dynamic orthoses are also more likely to be chosen by patients for their convenience. However, all types of orthoses are beneficial to patients' well-being. A change of footwear also helps to stop the progression of the deformity and prevents recurrence after surgery.
Impact of Intermittent Fasting on Alzheimer's Disease Risk: A Literature Review
Authors: Stencel Nicola Joanna , Szczot Jakub , Krala-Szkaradowska Magdalena , Skrzypczak Katarzyna Oktawia , Stuczyński Sebastian Krzysztof 
Published: October 2024

Introduction and purpose: In the face of an aging population, the increasing number of elderly individuals raises the incidence of age-related conditions, including Alzheimer's disease (AD), which is a leading cause of global disability and a significant burden on society. The lack of effective treatments for AD underscores the importance of prevention. Recent reports suggest that intermittent fasting (IF) may counteract the disease processes associated with AD and serve as a potential preventive strategy. This review aims to outline the impact of IF on the risk of developing Alzheimer's disease.Materials and methods: A literature search was conducted using the medical databases PubMed and Google Scholar. Articles were retrieved in English, employing the keywords: “Alzheimer’s disease”, “dementia”, “intermittent fasting”, “ketone bodies”, “cognition”.State of knowledge: IF is a dietary regimen involving cyclic restriction of food intake, practiced in many cultures and religions. The interest in IF has increased due to its numerous health benefits, and recent studies indicate its potential in delaying and preventing pathological processes associated with AD, such as β-amyloid accumulation, neuroinflammation, and vascular damage, making IF a potentially protective intervention against neurodegeneration.Summary: IF is a promising strategy for improving cognitive function and brain health. Due to the limited number of studies conducted on humans, further research is needed to confirm its effectiveness in preventing AD.
Examining teachers' motivation in conducting teacher professional development: A self-determination theory perspective
Authors: Purwanti Eko , Octavia Salma 
Published: October 2024

Teacher Professional Development (TPD) can be referred as any activities that can improve the quality of teacher professionalism. This study aims to find out various activities of English Secondary School teachers regarding their teacher professional development and to investigate their motivation in conducting TPD based on Self-Determination Theory (SDT). Underpinned by qualitative approach, this research used descriptive qualitative research design. Three English Secondary School teachers were involved as the participants, and individual interviews were used to collect the data. The findings showed that TPD activities done by the participants were 1) attending workshop and seminar, 2) joining English Subject Teacher Forum, 3) having informal peer discussions, and 4) reading teaching resources. The next findings regarding the teachers’ motivation in conducting TPD proves that the three aspects of SDT emerged from the participants, comprising 1) self-awareness, 2) in line with profession, and 3) the need to be competent. These findings imply that various activities of TPD driven by internal motivation can be conducted by English Secondary School teachers. Therefore, it is recommended that teachers have internal motivation in order to carry out TPD.
Efficacy and safety of intra-articular-only meropenem after one-stage revision for treating Escherichia coli-induced periprosthetic joint infection in a rat model
Authors: Li Yicheng , Wuermanbieke Shalitanati , Wang Fei , Mu Wenbo , Ji Baochao , Guo Xiaobin , Zou Chen , Chen Yanyang , Zhang Xiaogang , Cao Li 
Published: October 2024

AimsThe optimum type of antibiotics and their administration route for treating Gram-negative (GN) periprosthetic joint infection (PJI) remain controversial. This study aimed to determine the GN bacterial species and antibacterial resistance rates related to clinical GN-PJI, and to determine the efficacy and safety of intra-articular (IA) antibiotic injection after one-stage revision in a GN pathogen-induced PJI rat model of total knee arthroplasty.MethodsA total of 36 consecutive PJI patients who had been infected with GN bacteria between February 2015 and December 2021 were retrospectively recruited in order to analyze the GN bacterial species involvement and antibacterial resistance rates. Antibiotic susceptibility assays of the GN bacterial species were performed to screen for the most sensitive antibiotic, which was then used to treat the most common GN pathogen-induced PJI rat model. The rats were randomized either to a PJI control group or to three meropenem groups (intraperitoneal (IP), IA, and IP + IA groups). After two weeks of treatment, infection control level, the side effects, and the volume of antibiotic use were evaluated.ResultsEscherichia coli was the most common pathogen in GN-PJI, and meropenem was the most sensitive antibiotic. Serum inflammatory markers, weightbearing activity, and Rissing score were significantly improved by meropenem, especially in the IA and IP + IA groups ( p < 0.05). Meropenem in the IA group eradicated E. coli from soft-tissue, bone, and prosthetic surfaces, with the same effect as in the IP + IA group. Radiological results revealed that IA and IP + IA meropenem were effective at relieving bone damage. Haematoxylin and eosin staining also showed that IA and IP + IA meropenem improved synovial inflammation and bone destruction. No pathological changes in the main organs or abnormal serum markers were observed in any of the meropenem-treated rats. The IA group required the lowest amount of meropenem, followed by the IP and IP + IA groups.ConclusionIA-only meropenem with a two-week treatment course was effective and safe for PJI control following one-stage revision in a rat model, with less meropenem use.Cite this article: Bone Joint Res 2024;13(10):546–558.
Unexpected positive cultures in aseptic revision hip and knee arthroplasty
Authors: Kayani Babar , Mancino Fabio , Baawa-Ameyaw Joanna , Roussot Mark A. , Haddad Fares S. 
Published: October 2024

AimsThe outcomes of patients with unexpected positive cultures (UPCs) during revision total hip arthroplasty (THA) and total knee arthroplasty (TKA) remain unknown. The objectives of this study were to establish the prevalence and infection-free implant survival in UPCs during presumed aseptic single-stage revision THA and TKA at mid-term follow-up.MethodsThis study included 297 patients undergoing presumed aseptic single-stage revision THA or TKA at a single treatment centre. All patients with at least three UPCs obtained during revision surgery were treated with minimum three months of oral antibiotics following revision surgery. The prevalence of UPCs and causative microorganisms, the recurrence of periprosthetic joint infections (PJIs), and the infection-free implant survival were established at minimum five years’ follow-up (5.1 to 12.3).ResultsOf the 297 patients undergoing aseptic revisions, 37 (12.5%) had at least three UPCs obtained during surgery. The UPC cohort included 23 males (62.2%) and 14 females (37.8%), with a mean age of 71.2 years (47 to 82). Comorbidities included smoking (56.8%), hypertension (48.6%), diabetes mellitus (27.0%), and chronic renal impairment (13.5%). The causative microorganisms included Staphylococcus epidermidis (49.6%), Bacillus species (18.9%), Micrococcus species (16.2%), and Cutibacterium acnes (16.2%). None of the study patients with UPCs developed further PJIs or required further surgical intervention during follow-up.ConclusionThe prevalence of UPCs during presumed aseptic revision THA and TKA was 12.5%. The most common causative microorganisms were of low virulence, and included S. epidermidis, Bacillus species, Micrococcus species, and C. acnes. Microorganism-specific antibiotic treatment for minimum three months’ duration of UPCs in presumed aseptic revision arthroplasty was associated with excellent infection-free implant survival at mid-term follow-up.Cite this article: Bone Jt Open 2024;5(10):832–836.
Differential diagnosis of benign and lung adenocarcinoma presenting as larger solid nodules and masses based on multiscale CT radiomics
Authors: Xie Jiayue , He Yifan , Che Siyu , Zhao Wenjing , Niu Yuxin , Qin Dongxue , Li Zhiyong 
Published: October 2024

Purpose
To develop a better radiomic model for the differential diagnosis of benign and lung adenocarcinoma lesions presenting as larger solid nodules and masses based on multiscale computed tomography (CT) radiomics.

Materials and methods
This retrospective study enrolled 205 patients with solid nodules and masses from Center 1 between January 2010 and February 2022 and Center 2 between January 2019 and February 2022. After applying the inclusion and exclusion criteria, we retrospectively enrolled 165 patients from two centers and assigned them to the training dataset (n = 115) or the test dataset (n = 50). Radiomics features were extracted from volumes of interest on CT images. A gradient boosting decision tree (GBDT) was used for data dimensionality reduction to perform the final feature selection. Four models were developed using clinical data, conventional imaging features and radiomics features, namely, the clinical and image model (CIM), the plain CT radiomics model (PRM), the enhanced CT radiomics model (ERM) and the combined model (CM). Model performance was evaluated to determine the best model for identifying benign and lung adenocarcinoma presenting as larger solid nodules and masses.

Results
In the training dataset, the areas under the curve (AUCs) for the CIM, PRM, ERM, and CM were 0.718, 0.806, 0.819, and 0.917, respectively. The differential diagnostic capability of the ERM was better than that of the PRM and the CIM. The CM was optimal. Intermediate and junior radiologists and respiratory physicians achieved improved obviously diagnostic results with the radiomics model. The senior radiologists showed slight improved diagnostic results after using the radiomics model.

Conclusion
Radiomics may have the potential to be used as a noninvasive tool for the differential diagnosis of benign and lung adenocarcinoma lesions presenting as larger solid nodules and masses.