bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening for comorbid autoimmune disease should be considered in children with ANA positive juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort
Authors: Dahlberg Alma , Tydén Helena , Jöud Anna Saxne , Kahn Fredrik , Berthold Elisabet 
Published: October 2024

Abstract
Background
There is no consensus or clinical guidelines for screening routines of autoimmune disease in individuals with juvenile idiopathic arthritis (JIA), since results are conflicting whether the risk for such conditions is increased or not among individuals with JIA. The aim of this study was to investigate if the frequency of comorbid autoimmune conditions is increased after JIA diagnosis in a validated population-based JIA cohort in southern Sweden.

Methods
Autoimmune comorbidities were evaluated in a pre-existing population-based JIA cohort of 302 participants, constituting of individuals diagnosed with a validated JIA diagnosis 2000–2010 in southern Sweden. The comorbidities were determined through analysis of diagnosis codes registered after the JIA diagnosis and until 2019. With the use of a reference population of 1510 age- and sex matched individuals, hazard ratios (HR) were calculated with Cox proportional models.

Results
During the study period, 7.7% of the JIA cohort received an autoimmune diagnosis after their JIA diagnosis. Individuals with JIA had an increased risk of autoimmune diseases in general (HR 4.11, 95% CI 2.13–7.91) within the first 7 years of disease, as well as separately for coeliac disease (HR 5.24, 95% CI 1.76–15.65) and hypothyroidism (HR 3.74, 95% CI 1.14–12.30) compared to the reference population. Antinuclear antibody (ANA) positivity was associated with a significantly increased risk of comorbid autoimmune disease in the JIA cohort, with HR 6.21 (95% CI 1.64–23.55) for ANA positive individuals.

Conclusions
Individuals with JIA have a significantly increased risk of being diagnosed with an autoimmune condition after receiving their JIA diagnosis compared to matched references. ANA positivity is associated with a further increased risk. Our results emphasize awareness in physicians of additional autoimmune disorders in individuals with JIA and advocate serological screening of autoimmune conditions during follow-up.
Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury
Authors: Chen Zhangying , Ford Kacie P. , Islam Mecca B. A. R. , Wan Hanxiao , Han Hyebin , Ramakrishnan Abhirami , Brown Ryan J. , Villanueva Veronica , Wang Yidan , Davis Booker T. , Weiss Craig , Cui Weiguo , Gate David , Schwulst Steven J. 
Published: October 2024

AbstractPatients aged 65 years and older account for an increasing proportion of patients with traumatic brain injury (TBI). Older TBI patients experience increased morbidity and mortality compared to their younger counterparts. Our prior data demonstrated that by blocking α4 integrin, anti-CD49d antibody (aCD49d Ab) abrogates CD8+ T-cell infiltration into the injured brain, improves survival, and attenuates neurocognitive deficits. Here, we aimed to uncover how aCD49d Ab treatment alters local cellular responses in the aged mouse brain. Consequently, mice incur age-associated toxic cytokine and chemokine responses long-term post-TBI. aCD49d Ab attenuates this response along with a T helper (Th)1/Th17 immunological shift and remediation of overall CD8+ T cell cytotoxicity. Furthermore, aCD49d Ab reduces CD8+ T cells exhibiting higher effector status, leading to reduced clonal expansion in aged, but not young, mouse brains with chronic TBI. Together, aCD49d Ab is a promising therapeutic strategy for treating TBI in the older people.
Treatment of mild to moderate community-acquired pneumonia in previously healthy children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG-SIMG)
Authors: Donà Daniele , Brigadoi Giulia , Grandinetti Roberto , Pedretti Laura , Boscarino Giovanni , Barbieri Elisa , Matera Luigi , Mancino Enrica , Bergamini Marcello , Castelli Gattinara Guido , Chiappini Elena , Doria Mattia , Galli Luisa , Guarino Alfredo , Lo Vecchio Andrea , Venturini Elisabetta , Marseglia Gianluigi , Verga Maria Carmen , Di Mauro Giuseppe , Principi Nicola , Midulla Fabio , Esposito Susanna 
Published: October 2024

AbstractCommunity-acquired pneumonia (CAP) is an acute infection of the lung parenchyma acquired outside the hospital or other healthcare settings, typically affecting previously healthy individuals. This intersociety consensus aims to provide evidence-based recommendations for the antibiotic treatment of mild to moderate CAP in previously healthy children in Italy.A systematic review was conducted to identify the most recent and relevant evidence. Embase, Scopus, PubMed, and Cochrane databases were systematically screened, with a date restriction from 2012 to April 2024, but without language limitations. The review included studies conducted in high-income countries on antibiotic therapy in children over 3 months of age diagnosed with mild-moderate CAP. The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methods. The final recommendations were obtained through a Delphi consensus of an expert panel.Amoxicillin is the first-line treatment if the child is at least immunized against Haemophilus influenzae type b (low/very low quality of evidence, strong recommendations), while amoxicillin-clavulanate or second- or third-generation cephalosporins should be prescribed for those unimmunized or with incomplete immunization coverage for both H. influenzae type b and Streptococcus pneumoniae (low/very low quality of evidence, strong recommendations). Macrolides should be considered in addition to amoxicillin in children over 5 years old, if symptoms persist and the clinical condition remains good after 48 h of therapy (low/very low quality of evidence, strong recommendations). The dosage of amoxicillin is 90 mg/kg/day divided in three doses, although two doses could be considered to improve compliance (moderate quality of evidence, weak recommendations). A five-day duration of therapy is recommended, with clinical monitoring and re-assessment approximately 72 h after the start of antibiotic treatment to evaluate symptom resolution (moderate quality of evidence, strong recommendations).To improve the management of CAP in pediatric patients, we have developed this consensus based on a thorough review of the best available evidence and extensive discussions with an expert panel. However, further efforts are needed. Future research should focus on enhancing diagnostic accuracy, optimizing antibiotic utilization, comparing the efficacy of different antibiotic regimens, and determining the optimal dosage and duration of treatment in different setting.
Tranexamic Acid for reduction of intra- and postoperative TRansfusion requirements in elective Abdominal surgery (TATRA): study protocol for an investigator-initiated, multicenter, double-blind, placebo-controlled, randomized superiority trial with two parallel groups
Authors: Ronellenfitsch Ulrich , Kestel Anita , Klose Johannes , Rebelo Artur , Bucher Michael , Ebert Daniel , Mikolajczyk Rafael , Wienke Andreas , Kegel Thomas , Hering Julian , Haiduk Christian , Richter Michael , Steighardt Jörg , Grohmann Erich , Otto Lutz , Kleeff Jörg 
Published: October 2024

Abstract
Background
Intra- and postoperative hemorrhage is a relevant problem in major abdominal surgery, leading to acute anemia and necessitating transfusion of packed red blood cells. It is estimated that in 30% of abdominal surgeries, intra- or postoperative transfusion is required. Transfusion potentially has detrimental health effects and poses a considerable socioeconomic burden. Tranexamic acid, a lysine analog inhibiting plasminogen activation and providing clot stability, has been used to reduce hemorrhage. While there is ample evidence in other surgical disciplines, it is almost completely lacking in abdominal surgery.

Methods
This multicenter double-blind parallel group randomized superiority trial will compare tranexamic acid (loading dose 1000 mg over 10 min prior to skin incision, maintenance dose 125 mg/h continuously until skin closure or until 1000 mg have been administered) to placebo in patients ≥ 18 years undergoing elective esophagectomy, gastrectomy, colectomy, rectal resection, pancreatic resection, or hepatectomy. The primary efficacy endpoint is the intra- or postoperative transfusion of at least one unit of packed red blood cells. Key secondary endpoints are the number of transfused units per patient, estimated intraoperative blood loss, postoperative complications/mortality, length of hospital stay, operation/anesthesia time, D-dimer levels, and quality of life. Sample size calculation is based on the assumption that in the control group, 30% of patients require transfusion while the intervention achieves a risk reduction of 33%, reducing the probability to 20%. With a type one error of 5% and a power of 90%, using a two-sided χ2 test, this results in 412 patients per group. Accounting for non-compliance, 425 patients are to be randomized per group. The total trial duration will be 30 months with a recruitment period of 18 months.

Discussion
If the proposed trial yielded positive results, the routine use of tranexamic acid in major abdominal surgery would be supported. This would avoid acute anemia with detrimental effects such as tissue hypoxia and organ injury, as well as the negative immediate and delayed effects of transfusions.

Trial registration
EU CT Nr: 2023–509970-43–01, NCT06414031. Registered on 10 May 2024.
Evaluating the efficacy of support groups in the metaverse for Ukrainian refugees: a protocol for a randomized clinical trial
Authors: Giosan Cezar , Popoviciu Cătălina-Maria , Zhamaliyeva Saltanat , Zaborot Iuliana , Deac George 
Published: October 2024

Abstract
Background
The Ukrainian crisis, sparked by the Russian invasion, has generated one of the most extensive refugee crises in modern history. Addressing the mental health challenges of Ukrainian refugees is critical to promoting their resilience and successful integration into host communities. Traditional support group interventions might be challenging to implement for geographically dispersed populations, making the metaverse an innovative and inclusive platform for providing much-needed support to such populations.

Methods/design
Displaced Ukrainian refugee adults (18 years or older) without current psychiatric diagnoses or current involvement in therapeutic interventions are included in the study. Participants are randomized to one of three conditions: (1) Metaverse Support Groups, (2) In-Person Support Groups, or (3) Waitlist. Both intervention groups (Metaverse and In-Person) undergo 5 support group sessions, and data are collected at baseline, mid-intervention, post-intervention, and 3-month follow-up. Primary outcomes are depressive symptomatology and anxiety. Secondary outcomes are perceived social support, well-being, and gender-based violence awareness.

Discussion
To our knowledge, this is the first attempt to test the efficacy of support groups in the Metaverse for the Ukrainian refugee population. This study can thus add substantially to the body of knowledge on effective interventions and policies for refugees.

Trial registration
ClinicalTrials.gov Identifier: NCT06142032 (https://clinicaltrials.gov/study/NCT06142032). Registered on November 8, 2023.
Reliability and validation of an electronic penicillin allergy risk-assessment tool in a pregnant population
Authors: Wang Joanne , Elwood Chelsea , Paquette Vanessa , Kwan Natasha , Erdle Stephanie , Watt Melissa , Van Schalkwyk Julie , Bone Jeffrey N. , Roberts Ashley , Mak Raymond , Wong Tiffany 
Published: October 2024

Abstract
Background
Penicillin allergy adversely impacts patient care, yet most cases do not have true allergies. Clinicians require efficient, reliable clinical tools to identify low risk patients who can be safely de-labeled. Our center implemented the FIRSTLINE electronic point-of-care decision support tool to help non-allergist practitioners risk stratify patients with penicillin allergy. We sought to explore the reliability and validity of this tool in relation to allergist assessment and actual patient outcomes. We additionally compared it with two other published stratification tools, JAMA and PENFAST, to assess ability to accurately identify low risk patients appropriate for direct oral challenge.

Methods
In this single-center, retrospective, observational study, 181 pregnant females with self-reported penicillin allergy between July 2019 to June 2021 at BC Women’s Hospital, Vancouver, Canada were used to assess the reliability and validity of all three tools. Physician-guided history of penicillin use and symptoms were used for scoring. Results and recommendations were compared to actual patient outcomes after clinician decision for direct oral challenge or intradermal tests. We compared the performance of JAMA, PENFAST and FIRSTLINE.

Results
181 patients were assessed. 176/181 (97.2%) patients were deemed not allergic. Each risk stratification tool labelled majority of patients as low risk with 88.4% of patients PENFAST 0–2, 60.2% of patients JAMA low risk, 86.7% of patients FIRSTLINE very low risk.

Conclusion
We demonstrate that our point-of-care electronic algorithm is reliable in identifying low risk pregnant patients, as compared to an allergist assessment. To our knowledge, this is the first study to provide direct comparison between multiple decision support tools using the same population, minimizing participant bias. Providing clinical algorithms to risk stratify patients, can enable healthcare professionals to safely identify individuals who may be candidates for direct penicillin oral challenges versus needing referral to specialists. This increases the generalizability and efficiency of penicillin allergy de-labeling.
Economic growth and unemployment nexus: empirical test of Okun’s law in Somalia
Authors: Mohamed Abdisalan Aden 
Published: October 2024

AbstractThis paper aims to empirically examine the relationship between GDP and unemployment in Somalia from 2000 to 2021. The study also estimates Okun's coefficient. To evaluate the association between the unemployment rate and economic growth, we employ the Hodrick–Prescott (HP) filter detrending technique, the Augmented Dickey–Fuller (ADF) test, ordinary least squares (OLS), and fully modified OLS. The findings of this study demonstrate that the series is stationary at the level. However, the results confirm a statistically insignificant negative relationship between unemployment and economic growth. Consequently, our findings suggest that Okun's law does not apply in Somalia. For robustness, we employ fully modified ordinary least squares (FMOLS), canonical cointegrating regression (CCR), and dynamic ordinary least squares (DOLS). Nevertheless, the relationship between the GDP gap and unemployment is not strong enough to be considered statistically significant, and other factors may also influence unemployment. Therefore, policies aimed at reducing unemployment should take into account various factors, including education and training, labor market regulations, and social protection measures.
Density of pure and mixed NaCl and CaCl2 aqueous solutions at 293 K to 353 K and 0.1 MPa: an integrated comparison of analytical and numerical data
Authors: Hoffert Ulrike , André Laurent , Blöcher Guido , Guignot Sylvain , Lassin Arnault , Milsch Harald , Sass Ingo 
Published: October 2024

AbstractThis study reports on newly acquired density data of synthetically prepared pure and mixed NaCl and CaCl2 aqueous solutions that span a wide range of geothermally encountered concentrations and mixing ratios. The analytical data are provided for the temperature range of 293–353 K at ambient pressure. For the reproduction of that data, PHREESCALE was used. The predictive potential of this numerical tool regarding the density of geothermal fluids of known composition was the major target herein. As a result, the measured data are in good agreement with previous analytical studies found in the literature. Possible sources of errors are discussed in this paper. Density data of the mixed solutions at temperatures other than ambient are unique and close existing data gaps. The numerical model reproduces the newly measured and already existing density data within an error band of approximately 1%. For further use in geothermal applications, this can be considered an excellent agreement. Moreover, the model yields a direct calculation of density without the need to establish complex empirical equations of state and mixing rules. Finally, sensitivity calculations performed with a thermal–hydraulic (TH) numerical reservoir model demonstrate the required accuracy of fluid density for reliably predicting the long-term performance of deep geothermal energy systems. In terms of the productivity index and the timing of thermal breakthrough it shows that the present analytical and numerical uncertainty in density is small enough to reliably state both reservoir parameters.
Research on wheel/rail contact surface temperature and damage characteristics during sliding contact of a wheel
Authors: Wei Yunpeng , Han Jihao , Yang Tao , Wu Yaping , Chen Zhidong 
Published: October 2024

AbstractSevere friction on wheel/rail contact interface in the process of a train emergency braking can cause significant thermal and mechanical phenomena. Obvious friction heat and serious material damage will appear on the contact surface. In this article, the variation law of temperature and surface damage during a wheel sliding contact process are investigated. To achieve the research objective, a three-dimensional (3D) thermo-mechanical coupling contact finite element model (FEM) is established, and the temperature-dependent material parameters are used. The FEM is adopted to analyze the temperature distribution law on the contact surface. At the same time, a sliding contact testing machine is used to study the damage of materials in the contact area during the sliding contact. The study results indicate, the highest temperature of wheel and rail material is respectively 1014 ℃ and 461.8 ℃ during sliding contact. High temperatures are located at the subsurface and surface areas of contact region. When the distance to contact surface exceeds 1.4 mm, the temperature changes slightly. The types of damage on wheel surface are grooves and material peeling, while the flaky spalling, corrosive pitting, adhesion and grooves appear on the rail surface. Meanwhile, many cracks can be found on the contact surface, which is a major factor leading to material damage. The research results of this article are of great significance for understanding the thermal and mechanical damage of wheel/rail materials.
A comparison of the therapeutic efficacy of Tenofovir Disoproxil Fumarate and Entecavir in patients with chronic Hepatitis-B
Authors: Wang Huan , Wu Liping 
Published: October 2024

Objective: To compare the therapeutic efficacy of tenofovir disoproxil fumarate (TDF) and entecavir (ETV) in patients with chronic Hepatitis-B (CHB).
Methods: This retrospective study included 110 patients with CHB who received treatment at The First People’s Hospital of Linping District, Hangzhou from January 2021 to January 2023. Clinical data of the patients were reviewed and the patients were classified according to the treatment received: TDF group (n=53, patients received TDF treatment) and ETV group (n=57, patients received ETV treatment). Hepatitis-B virus deoxyribonucleic acid (HBV DNA) levels, liver function indicators, hepatitis-B e antigen (HBeAg) seroconversion rate, alanine transaminase (ALT) normalization rate, HBV DNA negative conversion rate, overall efficacy, and incidence of adverse reactions were compared.
Results: The total efficacy of the treatment in the TDF group was 94.33%, significantly higher than that in the ETV group (78.95%; P<0.05). After the treatment, the HBV DNA levels in both groups decreased compared to pretreatment levels, and were significantly lower in the TDF group compared to the ETV group (P<0.05). Both groups showed significant post-treatment improvement in liver function that was markedly better in the TDF group compared to the ETV group (P<0.05). The HBeAg seroconversion rate, ALT normalization rate, and HBV DNA conversion rate in the TDF group were significantly higher compared to the ETV group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups.
Conclusions: Compared with ETV, TDF has comparable adverse reaction profile but has more significant clinical effects in patients with CHB, improving HBeAg seroconversion rate, ALT normalization rate, and HBV DNA negative conversion rate. TDF is associated with lower HBV DNA levels after treatment and better improvements in liver function of patients.
doi: https://doi.org/10.12669/pjms.40.10.10307
How to cite this: Wang H, Wu L. A comparison of the therapeutic efficacy of Tenofovir Disoproxil Fumarate and Entecavir in patients with chronic Hepatitis-B. Pak J Med Sci. 2024;40(10):2390-2394. doi: https://doi.org/10.12669/pjms.40.10.10307
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In Search of Chronology: Narratives of Qur’anic Evolution in Western Academia
1
Authors: Stefanidis Emmanuelle 
Published: October 2024

Since the nineteenth century, Orientalist scholars have been preoccupied with recovering the original order of the Qur’an. In the past fifty years, the question appears to have reached an impasse with no sign of an emerging consensus. Divergences over the anchoring in space and time of the Qur’an have contributed to the diagnosis of “crisis” in (Western) Qur’anic studies.
What do the project of determining Qur’anic chronology and its failure tell us about Qur’anic studies in Western academia? What do the current impasses reveal about the nature of the Qur’an as a text and as a theological object? This study analyses disagreements over the Qur’an’s space and time by drawing on tools from literary theory and hermeneutics. It argues for a shift from a positivist to an interpretative paradigm. Moving away from the question of the actual historical order of the Qur’an, this article examines the making and the workings of diachronic readings of the Muslim scripture, with a particular focus on the works of two of the most prominent scholars in the field, Angelika Neuwirth and Nicolai Sinai. The aim of the exercise is double: first, to perform a critical reflection on the networks of meaning that we construct or inherit in our engagement with the Muslim scripture; and second, to apprehend better the nature of the Qur’an as an “open text” (Eco 1962) whose textual characteristics make it particularly prone to a number of interpretations.