bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation
Authors: Martin Samantha L. , Kala Rishabh , Tollefsbol Trygve O. 
Published: December 2017

Background:
Epigenetic modulations such as histone modifications are becoming increasingly
valued for their ability to modify genes without altering the DNA sequence. Many bioactive
compounds have been shown to alter genetic and epigenetic profiles in various cancers. Sulforaphane
(SFN), an isothiocyanate found in cruciferous vegetables such as kale, cabbage and broccoli
sprouts, is one of the most potent histone deacetylase inhibitors (HDACis) to date. Recently, it
has been identified that HDACis may play a vital role in regulating microRNAs (miRs) and human
telomerase reverse transcriptase (hTERT).

Objective:
The aim of our study was to identify if aberrant HDAC, hTERT and miR levels could be
regulated through novel dietary-based approaches in colorectal cancer (CRC) cells.

Methods:
We evaluated the in vitro epigenetic effects of SFN on CRC cells by MTT assay, cellular
density assay, real-time reverse transcriptase-polymerase chain reaction (RT-PCR), cell cycle analysis,
western-blot assay, HDAC activity assay and teloTAGGG telomerase PCR Elisa assay.

Results:
We demonstrated the inhibitory effects of physiologically relevant concentrations of SFN in
both HCT116 and RKO CRC cells, and showed for the first time that SFN treatment decreased cell
density, significantly inhibited cell viability and induced apoptosis in CRC cells. We also found that
practical doses of SFN significantly down-regulated oncogenic miR-21, HDAC and hTERT mRNA,
protein and enzymatic levels in CRC cells.

Conclusion:
Our studies suggest that the regulation of HDAC, hTERT and miR-21 is a promising
approach for delaying and/or preventing CRC and may be accomplished via the consumption of SFN
in cruciferous vegetables.
Lännessä olemme, itään katsomme<br>Ukrainan kriisin kehykset ja Venäjän esitykset suomalaisissa mediakuvissa
Authors: Kangas Jarkko , Ojala Markus , Pantti Mervi 
Published: December 2017

Artikkeli selvittää, millaisia merkityksiä Ukrainan kriisistä suomalaisen valtavirtamedian kuvasto rakentaa. Tutkimuksen aineistona ovat Helsingin Sanomien sekä Ylen ja MTV3:n televisiouutisten Ukraina-juttujen kuvat. Havaintoja verrataan kolmen ulkomaisen julkaisun kuvallisiin esityksiin. Representaatioita tutkitaan kahdesta näkökulmasta. Erving Goffmanin kehysteorian pohjalta tutkimme kuvien tarjoamia tilannemääritelmiä sekä ja niiden taustalla vaikuttavia kehyksiä. Toiseksi analysoimme, millaisia rooleja Venäjän presidentti Vladimir Putin mediakuvissa saa ja millaisia käsityksiä Venäjästä kuvat rakentavat. Havaintoja verrataan aiempaan tutkimukseen Suomen median Venäjä-käsityksistä. Kuvien analyysi nostaa esiin kaksi hallitsevaa tulkintakehystä. Politiikka-kehyksessä kriisi määrittyy poliittiseksi ongelmaksi, jonka ratkaisu on poliittisten prosessien varassa. Humaani kehys taas kohdistaa huomion inhimillisiin menetyksiin, suruun ja väkivallan seurauksiin. Lukijaa puhutellaan empaattisena myötäeläjänä, joka samaistuu ukrainalaisten ahdinkoon. Suomen mediassa politiikan painopiste oli kansainvälisessä politiikassa, kun taas ulkomaiset julkaisut korostivat enemmän Venäjän merkitystä. Presidentti Putin esitettiin mediakuvissa syytettynä, vahvana johtajana, Ukrainan arkkivihollisena ja poliittisen kamppailun voittajana. Poliittisesti Putin asemoitiin ensin lännen (MTV3) ja Ukrainan (Yle) ja myöhemmin Ukrainan (MTV3, YLE, HS) vastapuoleksi. Havainnot heijastavat suomalaiselle Venäjä-kuvalle keskeistä toiseuden ajatusta ja irrationaalista tulkintakehystä.
Eurokriisin politisoituminen suomalaisissa sanomalehdissä
Authors: Harjuniemi Timo , Herkman Juha , Ojala Markus 
Published: December 2017

Artikkelissa analysoidaan suomalaisten sanomalehtien tapaa politisoida eurokriisi vuosina 2010–2012. Politisoinnilla viitataan lehtien tapoihin tuottaa vaihtoehtoisia näkemyksiä ja ratkaisumalleja kriisistä sekä tuoda julkiseen keskusteluun erilaisia toimijoita. Tutkimuksen aineisto koostuu 971 eurokriisiä käsitelleestä lehtiartikkelista, jotka kerättiin Helsingin Sanomista, Kauppalehdestä, Kalevasta ja Ilta-Sanomista. Tutkimus on osa Oxfordin yliopiston Reuters-instituutin johtamaa kansainvälistä hanketta, jossa vertaillaan kymmenen EU-maan lehtien eurokriisijulkisuutta. Analyysin perusteella lehdistö käsitteli eurokriisiä enimmäkseen talouden näkökulmasta ja politisoi sitä pääosin erilaisten talouspoliittisten tulkintojen ja ratkaisutapojen kautta. Lehdistön hallitsevat kriisitulkinnat mukailivat eurooppalaisen päätöksentekoeliitin näkemyksiä, ja vaihtoehtoiset näkökulmat olivat harvinaisia. Vaihtoehtojen vähäisyyttä selittää pääosin se, että lehdistö suosi lähteenään varsin yksimielisesti esiintynyttä eurooppalaista päätöksentekoeliittiä. Myös ekonomisteilla oli merkittävä rooli julkisuudessa, ja he toivat keskusteluun jonkin verran vaihtoehtoisia näkemyksiä. Sen sijaan kansallisten poliitikkojen ja erityisesti kansalaisyhteiskunnan edustajien merkitys julkisuudessa jäi vähäiseksi. Yleissanomalehdet mukailivat eniten päätöksentekoeliittiä, talous- ja iltapäivälehti toivat keskusteluun hiukan useammin vaihtoehtoisia ääniä. Käsittelemällä kriisiä yksiäänisesti suomalainen lehdistö onnistui kaikkiaan varsin heikosti eurokriisin politisoimisessa.
Kuvajournalismi tiedon tuotantona
Authors: Mäenpää Jenni , Seppänen Janne 
Published: December 2017

Artikkelissa käsitellään empiirisen aineiston avulla objektiivisen lehtikuvan paradoksia, jossa kuvien myönnetään olevan aina-jo-käsiteltyjä, mutta samalla puolustetaan niiden käsittelemättömyyttä ja autenttisuutta. Tuorein esimerkki tulee Reutersilta, joka irtisanoi kuvaajan elokuussa 2006 kuvankäsittelyn vuoksi ja julkaisi sen jälkeen tiukat kuvankäsittelyä koskevat ohjeet.
Artikkelissa sovelletaan Michel Foucault’n tematisointeja tiedon ja vallan välisistä suhteista, ja kytketään niitä yhteen journalistisiin käytäntöihin liittyvän tutkimusperinteen kanssa. Artikkelissa vastataan siihen, millä tavoin käsitys objektiivisuudesta rakentuu kuvajournalistisissa käytännöissä ja toiseksi, miten objektiivisuus voidaan ymmärtää tiedon tuotannoksi Foucault’n teoretisointien valossa
El espacio urbano fulgurante. Anagogía laica en Times Square | The Flashing Urban Space. Laic Anagogy in Times Square
Authors: Rubio Hernández Rosana 
Published: December 2017

El espacio público urbano se ha ido transformando, desde finales del siglo XIX en un escenario, en el que el vidrio y la electricidad se alían para comunicar mensajes (informativos, publicitarios, decorativos o artísticos), construyendo lo que hemos denominado el espacio urbano fulgurante. En los espacios sagrados de la arquitectura bizantina y gótica, el vidrio también tuvo un papel determinante en la comunicación de información con fines anagógicos, en mosaicos y vidrieras. Nuestra época ha encontrado un arquetipo arquitectónico capaz de albergar a las multitudes que son objetivo de los mensajes de la “nueva religión” de la sociedad capitalista y de consumo. La solución ha sido convertir el propio espacio urbano en el nuevo “templo”. En él, las fachadas de los edificios existentes, se inundan de cartelería y pantallas de todo tipo, que lanzan incesantes mensajes sobre esos espacios, donde se congregan las masas de “nuevos fieles”. Nacen así lugares como Times Square. En el artículo se narra el origen y la historia de este enclave neoyorkino y la importancia que tuvieron personajes como S. L. Rothafel “Roxy” y D. Leigh en la definición de esta épica urbana del fulgor. Se analiza también su paralelismo con las arquitecturas sacras bizantina y gótica. El artículo concluye, instando a una reflexión crítica sobre las implicaciones que conllevan estos espacios, que están afectando al modo en que se viven las ciudades y al modo de hacer arquitectura.PALABRAS CLAVE: Times Square, Pantallas, Vidrio, Luz, Anagogía. Urban public space has been transformed, since the end of the 19th century, into a stage where glass and electricity are allied to communicate messages (whether informative, advertising, decorative or artistic), building what we have called the flashing urban space. In the sacred spaces of Byzantine and Gothic architecture, glass had also a decisive role in the communication of information with anagogical purposes, in mosaics and stained glass. Our age has found an architectural archetype capable of harboring the multitudes that are the target of the messages of the “new religion” of capitalist society and consumption. The solution has been to convert the urban space itself into the new “temple”. In it, the existing buildings’ facades are flooded with signs and screens of all kinds, which release ceaseless messages on those spaces where the masses of the “new faithful” congregate. Then, places like Times Square are born. The article narrates the origin and history of this New Yorker enclave. The importance of characters, such as S. L. Rothafel “Roxy” and D. Leigh, in the definition of this flashing urban epic is also explainded, and its parallelisms with the Byzantine and Gothic sacral architectures are also analyzed. The article concludes urging to a critical reflection on the implications of this kind of urban space, which is affecting the way cities are lived, and the way architecture is made.KEYWORDS: Times Square, Screens, Glass, Light, Anagogy.
Influence of juvenile idiopathic arthritis on the quality of life of young adults in the transition period to adult rheumatologic care
Authors: Dzhus Marta 
Published: December 2017

Background
Young adults with juvenile idiopathic arthritis (JIA) often have an active disease with significant functional impairment in adulthood that can affect their physical and mental functions

Aim
To determine the impact of JIA on quality of life (QoL) in young adults with JIA during the transition healthcare

Materials and methods
The cross-sectional study of 89 young adults aged 16 to 22 years with a history of JIA regardless of the presence or absence of active inflammation at the time of the survey was performed in the Oleksandrivsky Central Clinical Hospital in Kyiv, Ukraine in the period between April 2015 and February 2017. 25 age- and sex-matched controls (without rheumatic disease) were included. There was performed an evaluation of the age at disease onset, duration, JIA activity, received therapy and quality of life

Results
Out of 89, 37 (41,6%) patients were considered to be in remission. Juvenile idiopathic arthritis had a large impact on the physical scales of quality of life. Patients with JIA had worse (p <0.001) physical health in comparison with the control group. The pain was the most important factor affecting the quality of life in cases of juvenile idiopathic arthritis. The indices responsible for the physical (p<0.001), role (borderline significance, p=0.04) functioning, and intensity of pain (p<0.001) were decreased, compared with the control group. However, the indicators responsible for psychological function in patients with JIA did not differ from the control group. The correlation analysis revealed significant negative association between disability severity (HAQ) and physical function (r=-0,56, p<0.001), role function (r=-0,33, p<0.001), pain intensity (r=-0,60, p<0.001), general health (r=-0,40, p=0.01), vital activity (r=-0,46, p<0.001), social function (r=-0,48, p<0.001), mental health (r=-0,42, p<0.001)

Conclusion
In our transitional cohort of patients at the era of biological therapies, juvenile idiopathic arthritis had a larger effect on the physical than mental SF-36 subscale. The pain was the main factor influencing the quality of life
MULTIAGENT COLLABORATIVE COMPUTATION FOR AIRCRAFT MAINTENANCE SYSTEM
Authors: Sumari Arwin Datumaya Wahyudi , Ahmad Adang Suwandi 
Published: December 2017

Quick-and-accurate decision is a primary requirement for achieving a mission’s successfulness in many organizations whether they are militaries or civilians. The larger and more complex the scope of a mission the longer the time will be needed to perform decision-making. A complex mission such as retaining a sustainable mission of aircrafts deployed in certain remote bases will require a 24-hour of standby on-site or off-site maintenance teams. The most common problem arisen from humans in such situations is the fatigue that can occur anytime to any of them during a continuing mission and of course, it can affect the continuity of the mission and delay or disappoint the mission achievement. In this paper we address the concept of the utilization of Multiagent Collaborative Computation (MCC) paradigm in supporting the decision-making process in aircrafts maintenance during a sustainable mission in remote bases. The ultimate goal of the MCC-based aircraft maintenance system is comprehensive information regarding the maintenance procedures in order to keep the aircrafts serviceable during the mission implementation. In this paper we also present the technique to obtain the comprehensive information as the basis for decision-making called A3S (Arwin-Adang-Aciek-Sembiring) information-inferencing fusion method
STRATEGI PENINGKATAN MUTU KEAMANAN PRODUK BAKERI INDUSTRI KECIL MENENGAH MELALUI PENERAPAN GOOD MANUFACTURING PRACTICES (GMP) = THE STRATEGY OF IMPROVING FOOD SAFETY BASE ON IMPLEMENTATION GOOD MANUFACTURING PRACTICES (GMPâ€™S) ON SMALL-MEDIUM ENTERPRISES
Authors: Himawan Adinegoro  
Published: December 2017

Abstract
The objective of this research is to formulate strategy of improving food safety base on implementation Good manufacturing Practices (GMPâ€™s). This paper presents a Swot analysis regarding the implementation of GMPâ€™s on smallmedium enterprises bakery in Bogor. SWOT is an expert choice justification model which is used to engineer the structural analysis model by taking several elements of the strategic environmental factors. SWOT analysis for the strategic environmental factors has identified the significant aspect of the supporting elements, constraints and, the groups of the alternative strategy. Interpretative Structural Modelling (ISM) is used to find out the principal sub-elements of each strategy and stakeholders elements have been analysed to enrich the formulate strategy. Complete analysis of this research has built alternative formulation strategy for region superiority improving food safety base on implementation GMPâ€™s, with considering respective limitation.
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Abstrak
produk bakeri pada industry kecil menengah melalui penerapan praktekpengolahan terbaik (GMP). Metoda yang digunakan dalam penelitian ini adalah analisa SWOT. Analisa SWOT merupakan salah satu alat analisis kualitatif yang digunakan untuk mengidentifikasi peluang dan ancaman dalam melakukan kegiatan dengan mengacu pada kekuatan dan kelemahan yang dimiliki stakeholders industri kecil menengah produk bakeri di kota Bogor. Penggunaan teknik Interpretive Structural Modeling (ISM) pada analisis SWOT untuk melihat hubungan kontekstual antar elemen dan hirarki untuk elemen penyusun strategi. Hasil analisis dari ke dua model (analisis SWOT dan ISM) dalam penelitian ini adalah strategi terbaik dengan keterbatasan ahli dalam rangka peningkatan mutu keamanan produk bakeri berdasarkan GMP.
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PENGARUH PENGHILANGAN KEKASARAN PERMUKAAN TERHADAP KEKUATAN FATIK = EFFECT OF SURFACE ROUGHNESS REMOVAL TO FATIGUE STRENGTH
Authors: H. Agus Suhartono  
Published: December 2017

The aim of the study is to investigate and to prove that the fatigue failure of steel is initiated from the surface. Hence the preventif action of smoothening the surface that has been loaded by fatigue loading is very important. The specimen of AISI 1045 Steel is loaded by means of rotary bending fatigue. The fatigue loading will be interupted as the fatigue life reaching 50% of fatigue life and 75% of fatigue life. During the interuption the specimen will be grinded and polished, before tested completely until fatigue fracture occured. The fatigue life of each group of scpecimen based on the art of loading will be compared to the specimen tested by fatigue loading without interuption.The Miner rule is used to evaluated the test result. The influence of interuption and surface treatment is evaluated and analyzed.
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ABSTRAK
Tujuan penelitian ini adalah untuk menyelidiki dan membuktikan bahwa kegagalan kelelahan baja dimulai dari permukaan. Oleh karena itu tindakan pencegahan dengan memperhalus permukaan sangat penting untuk mencegah beban kelelahan baja. Spesimen dari AISI 1045 Steel dimuat dengan cara uji kelelahan lentur putar. Kelelahan pemuatan akan disela sebagai umur kelelahan mencapai 50% dari umur kelelahan dan 75% dari umur kelelahan. Selama gangguan lainnya yang spesimen akan digiling dan dipoles, sebelum diuji benar-benar sampai patah akibat kelelahan yang terjadi. Umur kelelahan dari setiap kelompok specimen diuji berdasarkan beban akan dibandingkan dengan spesimen oleh kelelahan bongkar tanpa aturan. The Miner rule digunakan untuk mengevaluasi hasil tes. Pengaruh gangguan lainnya dan perlakuan permukaan dievaluasi dan dianalisis.
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PERHITUNGAN JARAK JANGKAU MAKSIMUM PESAWAT UDARA NIR AWAK BPPT UNTUK MISI STRATEGIS DETERMINING = THE MAXIMUM FLIGHT RANGE OF BPPTâ€™S UAV FOR STRATEGIC MISSION
Authors: Jemie Muliadi  , Endarmadi A. Prayitno  , Heri T. Muryanto  
Published: December 2017

The Agency for The Assessment and The Application of Technology (BPPT, Indonesia) has developed several UAV prototypes for various of mission. The missions to be accomplished were including military purposes and also civilian application. To validate the capability of these UAV in performing their defined mission, thereâ€™s a requirement to calculate the flight performance parameters. The relevant parameters were including maximum flight range, maximum altitude, flight endurance, etc. The flight range is a crucial parameter to be determined for a UAV for its suitable mission. Thus, this work will be focused on the Maximum Range determination of PUNA BPPT. The data from BPPTâ€™s UAV flight tests will be processed to obtain the aerodynamic parameters as inputs for maximum flight range calculation. The maximum range resulted were occurred in an optimum value of cruising speed. While varying the cruising speed will affect the maximum range attained, the variation will also be analyzed, and the effect will be concluded.
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ABSTRAK
Badan Pengkajian dan Penerapan Teknologi telah mengembangkan Pesawat Udara Nir Awak untuk berbagai misi. Selain misi yang terkait dengan aplikasi pertahanan dan keamanan, PUNA BPPT dikembangkan pula untuk misi-misi non militer. Sebagai validasi kemampuan PUNA BPPT dalam memenuhi misi terebut, maka perlu diketahui ukuran-ukuran performa yang relevan. Ukuran-ukuran tersebut meliputi,jarak jangkauan terbang maksimun, ketinggian terbang maksimum, ketahanan lama terbang, dan sejenisnya. Jarak jangkauan terbang (range) merupakan parameter yang krusial dalam Operasional Pesawat Udara Nir Awak. Makalah ini menyajikan perhitungan jangkauan terbang maksimum PUNA BPPT. Data hasil uji terbang PUNA BPPT diolah untuk menghasilkan parameter aerodinamika yang akan menjadi masukan dalam perhitungan jarak jangkauan terbang PUNA. Jarak jangkau maksimum ini akan mencapai nilai optimum pada suatu nilai kecepatan jelajah optimum. Maka, variasi kecepatan jelajah akan dianalisa dan efeknya akan disimpulkan terhadap Jangkauan Terbang PUNA BPPT.
Motive für das zweite Kind. Eine qualitative Sekundäranalyse problemzentrierter Interviews
Authors: Holubek Stefan 
Published: December 2017

The two-child family is a widespread ideal. It is, however, not a matter of course. Based on Miller’s Traits-Desires-Intentions-Behavior model, this paper investigates the motives of people for desiring a second child and how these motives may influence the progression towards intending this first family extension. The study uses secondary analyses of problem-centered interviews that are based on grounded theory methodology. As a result, four types of motives are identified. The second child may be interpreted as (a) a necessary component of the traditional family setting, as (b) a matter of course, (c) as a first sibling, and as (d) a “doubled” first child. Each of these motives has been scrutinized with regard to the specific circumstances causing people to intend having a second child. It is shown that identifying the respective motives for having a second child leads to a better understanding of the circumstances upon which particular actors start planning to actually have a second child.
Zusammenfassung
Zwei Kinder zu haben ist ein weit verbreitetes Ideal, aber keine Selbstverständlichkeit. Ziel dieses Beitrages ist es, orientiert am „Traits-Desires- Intention-Behaviour“-Modell nach Miller, Motive für den Wunsch nach einem zweiten Kind und ihre Rolle für den Übergang zur Intention zu untersuchen. Dafür werden problemzentrierte Interviews auf Grundlage der Grounded-Theory-Methodologie sekundär ausgewertet. Als Ergebnis werden vier Motive vorgestellt. Zweite Kinder werden als Teil eines traditionalen Familienbildes, als dispositionelle Selbstverständlichkeit, als „erstes Geschwisterkind“ und als „wiederholtes“ erstes Kind gedeutet. Die Motivlagen werden jeweils danach befragt, welche Informationen über Voraussetzungen für den Übergang in die Planungsphase sie enthalten. Dabei wird gezeigt, dass das Wissen über die Motivlagen dabei hilft, zu konkretisieren, unter welchen Bedingungen bestimmte Akteure dazu übergehen, das zweite Kind zu planen.
On choosing the energy–momentum tensor in electrodynamics and on the Abraham force
Authors: Spirichev Yu A 
Published: December 2017

Abstract
The highly debated problem of choosing the energy–momentum tensor in electrodynamics is examined. Electromagnetic forces in a continuum medium that follow from the Minkowski and Abraham tensors are considered. It is shown that the conservation equations for both Minkowski’s momentum density and Abraham’s momentum simultaneously follow from the Minkowski tensor and that they are the components of a composite electromagnetic momentum in the medium. It is shown that choosing canonical matter equations reduces the Abraham force to zero. We argue in favor of choosing the Minkowski tensor and show the incompleteness of the Abraham tensor.
Wavelength Does Not Equal Pressure: Vertical Contribution Functions and Their Implications for Mapping Hot Jupiters
Authors: Dobbs-Dixon Ian , Cowan Nicolas B. 
Published: December 2017

Abstract
Multi-band phase variations, in principle, allow us to infer the longitudinal temperature distributions of planets as a function of height in their atmospheres. For example, 3.6 μm emission originates from deeper layers of the atmosphere than 4.5 μm due to greater water vapor absorption at the longer wavelength. Because heat transport efficiency increases with pressure, we expect thermal phase curves at 3.6 μm to exhibit smaller amplitudes and greater phase offsets than at 4.5 μm—yet this trend is not observed. Of the seven hot Jupiters with full-orbit phase curves at 3.6 and 4.5 μm, all of them have greater phase amplitude at 3.6 μm than at 4.5 μm, while four of the seven exhibit a greater phase offset at 3.6 μm. We use a 3D radiative-hydrodynamic model to calculate theoretical phase curves of HD 189733b, assuming thermo-chemical equilibrium. The model exhibits temperature, pressure, and wavelength-dependent opacity, primarily driven by carbon chemistry: CO is energetically favored on the dayside, while CH4 is favored on the cooler nightside. Infrared opacity, therefore, changes by orders of magnitude between day and night, producing dramatic vertical shifts in the wavelength-specific photospheres, which would complicate eclipse or phase mapping with spectral data. The model predicts greater relative phase amplitude and greater phase offset at 3.6 μm than at 4.5 μm, in agreement with the data. Our model qualitatively explains the observed phase curves, but it is in tension with current thermo-chemical kinetics models that predict zonally uniform atmospheric composition due to the transport of CO from the hot regions of the atmosphere.