bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Valuable is Uroflowmetry in Children with Enuresis Nocturna?
Authors: Çakıroğlu Basri , Gözüküçük Ali , Cesur Ilknur Banlı 
Published: September 2024

Abstract

Objective:
Enuresis nocturna is an important social and psychological problem in children. Uroflowmetry (UF) is a noninvasive urodynamic test that is performed in daily clinical practice to evaluate urinary function. In UF evaluation, urine amount, urination time, latency time, maximum urine flow rate access time, maximum urine flow rate, and mean urine flow rate are evaluated. The objective of the study was to evaluate the UF results of children with primary nocturnal enuresis (PNE).

Materials and Methods:
The UF findings of healthy and visualized children without any urinary symptoms and who were prospectively admitted to the urology and pediatric surgery outpatient clinic with the complaint of PNE were compared. Information and UF results of PNE and healthy children included in the study were recorded. In this research, we compared the clinical characteristics and features of bladder assessment: UF, postvoid residuals, and bladder wall thickness between boys and girls with PNE and the clinical characteristics and bladder assessment between children with primary and secondary PNE.

Results:
A total of 183 children, comprised 103 potty-trained children with PNE and 80 potty-trained healthy children were included in the study. There were 60 children in the PNE group and 62 children in the control group. There was no statistically significant difference between the groups in terms of age. When the UF findings of both groups were compared, it was found that only maximum flow was higher in the children with PNE. In other parameters, there was no difference between the two groups. The Qmax in the group with PNE and the control group was found to be 20.48 ± 6.57 ml/s and 17.22 ± 6.17 ml/s, respectively (P = 0.001).

Conclusions:
The present study reveals that there is no difference between patients with enuresis nocturna and healthy individuals in terms of UF. Therefore, UF is not recommended for use in differential PNE diagnosis.
Efficacy of cryoneurolysis in the management of chronic non-cancer pain: A systematic review and meta-analysis
Authors: Goyal Sonal , Kumar Ajit , Sharma Ravi Shankar , Goyal Divakar , Singh Girish Kumar 
Published: September 2024

ABSTRACT

Background and Aims:
Cryoneurolysis, a neuroablative technique, is used in the event of failure of conservative treatment in chronic pain conditions. To date, no systematic review has been published to demonstrate its effectiveness in managing chronic non-cancer pain. Therefore, this review was done to ascertain the efficacy of cryoneurolysis and describe its role in chronic non-cancer pain management.

Methods:
We searched PubMed, Cochrane, Embase, Scopus, and Google Scholar databases for articles published between January 2011 and September 2021. Two independent reviewers extracted the data from the included studies. Assessment of risk of bias of included randomised controlled trials (RCTs) was done using RevMan 5.4.1 software and Newcastle-Ottawa scale was used for non-randomised studies.

Results:
Ten studies enroling a total of 425 patients were included in the qualitative analysis. Eight studies were assessed quantitatively. RCTs were found only for cervicogenic headache and knee osteoarthritis management. The rest of the included studies were prospective non-controlled and retrospective studies. A significant pain reduction was seen at seven-day [Standardised Mean Difference (SMD) 1.77 (1.07, 2.46)], P < 0.00001, I2 = 79%), one-month (SMD 3.26 [2.60, 3.92], P < 0.00001, I2 = 45%), three-month (SMD 2.58 [1.46, 3.70], P < 0.00001, I2 = 93%), six-month (SMD 2.38 [0.97, 3.79], P = 0.001, I2 = 86%) follow-ups. Improved disability and no serious complications were noted.

Conclusion:
Cryoneurolysis appeared to be effective in pain alleviation in refractory painful conditions for up to six months. It is safe and well-tolerated with an excellent safety profile but the quality of evidence is limited by substantial heterogeneity between trials. Therefore, more comparative clinical trials on a larger sample size are needed to provide more concrete evidence.
Pap smear changes and cervical inflammation in women with infertility in correlation to clinical and microbiological findings
Authors: Bose Arshiya , Acharya Mousumi , Panigrahi Kumudini , Pradhan Prita , Dash Kanakalata 
Published: September 2024

Abstract

Introduction:
One of the prime causes of infertility is reproductive tract infections as they can produce marked cervical inflammation. These can be seen in Pap smears at various stages as cervical health plays an imperative role in blocking ascending infections. This study assesses infections and related changes in Pap smears from women with infertility and its association with clinical and microbiological findings.

Materials and Methods:
A prospective observational study was done for 3.5 years. Pap smears of women with infertility were taken, and those showing significant inflammation (>50%) were studied. Relevant history and “per-speculum” findings were noted. Pap smear changes, infections or intraepithelial changes, and lactobacilli were studied. High vaginal swab culture was done, and follow-up conception data were correlated.

Results:
Almost 50% of women with inflammatory smears showed the presence of an infection; of which the most common was candidiasis followed by bacterial vaginosis. Out of the 12 women whose culture reports were available, 11 showed growth (90%). Most women showed depleted lactobacilli. On follow-up, the conception rate despite assisted reproductive technology was significantly lower in women with Pap smear changes (P = 0.0002).

Conclusion:
These observations show a strong and significant association between inflammatory Pap smears, infections in the reproductive tract, depleted lactobacilli, and conception. It is advisable that a Pap smear should be done in all cases of infertility to look for infections and inflammation, and a follow-up with high vaginal swab culture should be done in cases where inflammation is detected in a Pap smear.

The following core competencies are addressed in this article:
Patient care and procedural skills, Medical knowledge, Practice-based learning and improvement.
Efficiency of Different Agitation Methods for Removal of Calcium Hydroxide Intracanal Medicament Mixed with Two Different Vehicles from Canals of Mandibular Premolars: A Volumetric Analysis using Cone-beam Computed Tomography
Authors: Gautam Tiwari , Renu Aggarwal , Jindal Neetu , Arshdeep Gill , Monika Choudhary 
Published: September 2024

Introduction:
The purpose of this research was to use cone-beam computed tomography (CBCT) to examine the efficacy of hand and rotary files, manual dynamic agitation, and inactive ultrasonic actions in removing Ca(OH)2 from root canal surface when used in conjunction with two distinct vehicles.

Materials and Methods:
Using the ProTaper Gold file system, the root canals of 100 mandibular premolars were cleaned and shaped up to file F2, and then filled with either Ca(OH)2 + saline or Ca(OH)2+ camporated monochloro-phenols. After 7 days of incubation, CBCT was used to do a prevolume analysis. Several forms of agitation were used to successfully remove calcium hydroxide (K- and H-file, ProTaper Gold rotary file, passive ultrasonic irrigation (PUI), and manual dynamic agitation). CBCT was used to reevaluate the volumes after the fact, & the percentage of change was determined the Post Hoc Tukey test, One-way ANOVA, & the Dunn test were utilized to analyse the data statistically.

Results:
Saline-based Ca (OH) 2 was little simple to be separate than camporated monochloro-phenols (CMCP)- based group. When the agitation systems were compared, H-file in both the groups removed more calcium hydroxide from root canals than other systems (P < 0.01).

Conclusion:
The H-file system and PUI were more effective than the K-file, rotary, and manual dynamic agitation methods in eliminating calcium hydroxide from root canals. However, the saline-based calcium hydroxide was easier to be removed than camphoro monochlorophosphate.
C-Reactive Protein Levels
Authors: Mouneshkumar CD , Deepa  , Gulati Saakshi , Jha Abhinav , Khangembam Monica , Gupta Shivangi , Gupta Parkhi 
Published: September 2024

Background:
C-reactive protein (CRP) is a nonglycosylated pentameric polypeptide comprising 206 amino acid residues. CRP causes activation of the classical complement pathway by binding to various autologous and extrinsic ligands exposed on membranes of injured, necrotic, or cells undergoing apoptosis. There is evolving evidence which strongly suggests that CRP is an inflammatory marker and is significantly elevated in patients diagnosed with tumors such as hepatocellular, pulmonary, and breast carcinomas. In addition, serum CRP level has been shown to be associated with size of tumor (T), clinic-pathological characteristics, and metastasis to lymph nodes.

Aim:
The aim of this study was to compare serum CRP levels in potentially malignant disorders and oral malignancies.

Materials and Methods:
This cross-sectional prospective study was designed to study serum CRP levels in patients with oral potentially malignant disorders (leukoplakia and oral submucous fibrosis), patients with oral squamous cell carcinoma, and normal controls. Study participants were divided into four groups: (1) Group I comprising 40 patients with leukoplakia, (2) Group II comprising 40 patients with oral submucous fibrosis, (3) Group III comprising 40 patients with oral squamous cell carcinoma, and (4) Group IV comprising 40 controls. Five milliliters of venous blood was collected after venipuncture from the antecubital vein followed by centrifugation, and serum was separated. This separated serum was analyzed for CRP levels using SPINREACT kit and semi-automated biochemical analyzer (Kyoto, Japan). All obtained data were entered into Microsoft Excel Worksheet 2007, and tabulations were performed using SPSS 16 (Statistical Package for the Social Sciences) software (IBM Corporation, Chicago, IL, USA). P < 0.05 was considered statistically significant.

Results:
Mean ± standard deviation values derived were 5.5 ± 4.8 mg/dl (Group I), 6.1 ± 4.9 mg/dl (Group II), 10.5 ± 2.4 mg/dl (Group III), and 2.1 ± 1.6 mg/dl (Group IV), respectively. On applying one-way analysis of variance for comparison of three groups, P < 0.003 was obtained. The results implied that an extremely significant statistical correlation existed between all studied groups when serum CRP levels were compared.

Conclusion:
Serum CRP levels are prognostic markers in oral potentially malignant disorders and oral malignancies.
Periodontal Manifestations as Related to the Cytokines in the Gingival Crevicular Fluid
Authors: Pandit Nymphea , Bhavsar Neeta 
Published: September 2024

Backround:
Periodontal diseases are classified into different categories based on the clinical symptoms and related to these there can be changes in the cytokine levels in the connective tissue and elaboration of these in the gingival crevicular fluid. (GCF).

Aims and objectives:
The aim of this study was to evaluate the levels of IL-11 and IL-17 in the gingival crevicular fluid of patients with Aggressive Periodontitis and Chronic Periodontitis and co-relate them with the clinical parameters.

Materials and Methods:
GCF was collected from the deepest sites of the periodontitis patients and ELIS A was used to determine the levels of IL-11 and IL-17 levels.

Results:
GCF of patients in each category was assayed and the levels of IL-11 and IL-17 were co-related with clinical symptoms. Conclusion: Study showed strong co-relation of Aggressive and Chronic Periodontitis with IL-11 and IL-17.
Faculty Members' Perception of the Challenges and Prospects of Online Learning in Dental Institutes in India during the COVID-19 Pandemic Scenario
Authors: Samra Rupandeep Kaur , Nirola Ashutosh , Verma Anupama , Nagpal Archana , Malik Gauri , Singh Thind Gurinder Bir 
Published: September 2024

Aim:
The aim of this study was to determine the impact and challenges of emergency remote teaching faced by the dental faculty during the first and the second wave of COVID-19 in India.

Materials and Methods:
A cross-sectional descriptive questionnaire study was carried out consisting of two surveys. Data for the first questionnaire was recruited from 135 faculty members engaged in online teaching and comprised details about sociodemographic, designation, teaching experience, online teaching practices, perceptions, and challenges faced by the faculty members during online teaching during the first wave of COVID-19 pandemic in India. Categorical variables were reported as counts and percentages. Group comparisons were made with the Chi-square test. The same participants were given the second questionnaire to access their efficacy in overcoming the challenges faced by them during the second wave.

Results:
54.8% of the participants were female. 46.7% of respondents were Professors by designation. Variation was evident for the personal, technical, financial barriers and challenges caused by students' attitude with designation as a variable. 67.4% of the participants devoted extra time to prepare their lectures. 62.2% of the faculty faced network issues. 53.3% of the faculty reported increased expenditure on data. Maximum challenges were seen in the category based on students' attitude which deteriorated the quality of the lectures. 74.1% of the teachers agreed that online teaching was better for theoretical learning. There was not much difference observed in the response regarding personal barriers among faculty members with gender as a variable in the first wave, but notable differences were seen for technical barriers, especially lack of formal training. During second-wave study, Internet connectivity still remained a barrier.

Conclusion:
Challenges faced by the faculty members regarding online learning decreased in the second wave as compared to the first wave, but network connectivity and students' attitude remained an issue. Scope of theoretical online teaching was perceived to be better as compared to practical teaching.
Menorrhagia in inherited bleeding disorders in Iraqi women
Authors: Yaseen Yusra Ghiath , Hmeed Elaf Zuhair , Al Rahal Nidal Karim , Mtashar Baan Abdulatif 
Published: September 2024

Abstract:

BACKGROUND:
Menorrhagia, or excessive menstrual bleeding, is a common symptom in women with inherited bleeding disorders; they are conditions where the blood ability to clot is impaired. Some of the common bleeding disorders include von Willebrand disease (VWD), clotting factor deficiencies, and platelet function disorders.

OBJECTIVE:
To assess different types of inherited bleeding disorders in women with menorrhagia referred to the National Center of Hematology/Mustansiriyah University in Baghdad/Iraq.

PATIENTS AND METHODS:
A prospective study was carried out on 193 women who had experienced menorrhagia for a duration of 3 years, from 2020 to 2023. These women sought consultation at the National Centre of Hematology/Mustansiriyah University. All participants were diagnosed through various laboratory tests, including complete blood count, blood film, blood group and Rh, bleeding time, prothrombin time, activated partial thromboplastin time, fibrinogen level, factor assay, von Willebrand factor antigen using ELISA technique, ristocetin cofactor, and platelet function test.

RESULTS:
Out of the 193 women with menorrhagia who participated in this study, the majority of whom had an unidentified cause (36.3%), followed by VWD (30.1%) and platelet function disorders (21.2%). Other bleeding disorders ( thrombocytopenia and factors deficiencies) were 5.7% and 6.7%, respectively. Furthermore, the results showed that there was a significant difference in family history and consanguinity between patients with a hereditary bleeding disorder and nonhereditary bleeding disorder (P < 0.001).

CONCLUSIONS:
Fifty eight percent of females with Menorrhagia in this study have inherited bleeding disorders(IBDs), VWD, and thrombasthenia account for 51.3% are the most common causes of inherit bleeding disorder (IBD). Consanguineous marriage should be discouraged in Iraqi society to reduce such inherited diseases.
Clinical, Histopathological, and Molecular Characterization of Leprosy in an Endemic Area of the Colombian Caribbean
Authors: Fragozo-Ramos Maria Carolina , Cano-Pérez Eder , Sierra-Merlano Rita Magola , Camacho-Chaljub Francisco , Gómez-Camargo Doris 
Published: September 2024

Background:

Mycobacterium leprae was considered the only causal agent of leprosy until Mycobacterium lepromatosis was identified' which it has been suggested has greater pathogenicity and is linked to diffuse lepromatous leprosy (DLL) and Lucio's phenomenon (LPh). Our objective is to identify Mycobacterium spp. in an endemic area of leprosy in Colombia.

Methods:
The study included cases with a diagnosis of leprosy by clinical and histopathological analysis. DNA extraction and two specific rounds of semi-nested polymerase chain reaction (PCR) were performed in paraffin biopsies skin to identify M. leprae and M. lepromatosis. Demographic, clinical, and histopathological data were extracted and tabulated for analysis.

Results:
Forty-one cases of leprosy were analyzed. The most frequent clinical diagnosis was lepromatous leprosy (36.6%); there was one case with DLL and two with LPh. The most common histopathological finding was tuberculoid leprosy (36.59%); three cases had negative histopathology. M. lepromatosis was not detected; all cases corresponded to M. leprae including cases with negative histopathology' DLL, and LPh.

Conclusion:
In this study, M. leprae was the causative agent of leprosy, encompassing even its most severe phenotypic forms. It is appropriate to consider PCR as an indispensable tool for the diagnosis of leprosy and to continue to carry out the active search for M. lepromatosis.
Tubercular Lymphadenitis in the 21st Century
Authors: Gupta Akshita , Kunder Supriya , Hazra Druti , Shenoy Vishnu Prasad , Chawla Kiran 
Published: September 2024

Background:
Tubercular lymphadenitis (TBLN) remains the most frequent manifestation for extrapulmonary TB despite advancements in diagnostics and management over the years. Our study intends to explore five-year trend of TBLN in a tertiary care centre from south India, and aims to study clinico-demographic and diagnostic factors in the management of TBLN.

Methods:
All the adult patients (≥18 years) diagnosed and confirmed for TB lymphadenitis between January 2015 to December 2019 were retrospectively evaluated. Demographic factors, clinical manifestations, and different diagnostic approaches used in the management of TBLN were analysed using SPSS ver. 16.

Results:
A total of 164 patients with confirmed TBLN were included. Patients aged 18-45 years were the most affected (63.41%) with female dominancy. The most affected lymph nodes were cervical lymph nodes (84.1%) presenting with single palpable enlarged lymph node (80.5%). Majority (78.7%) of the lymph nodes were non-matted and 68.9% of enlarged lymph nodes were >3cm size. Excisional biopsy was performed for the majority of the patients 99 (60.4%) and 60.4% of the cases were managed with a combination of surgical excision and anti-tubercular treatment (ATT).

Conclusions:
The declining trend of TBLN observed in this study highlights the outcome of good public health policies; however, young females and high-risk groups like HIV infected or AIDS (affected more in the study) demand further attention. Overall, the advanced diagnostic tools along with surgical management and ATT can lead us to earlier diagnosis and successful treatment outcomes
Molecular identification of Malassezia from the skin scrapings of clinically suspected cases of pityriasis versicolor
Authors: Kiran Kanchankoti , Rudresh Shoorashetty Manohar , Raksha Yoganand , Ragunatha Shivanna , Jyoti Gupta , Shivaprakash Mandya Rudramurthy 
Published: September 2024

ABSTRACT

Background:
Pityriasis versicolor (PV) is caused by a lipophilic fungus belonging to the genus Malassezia. Potassium hydroxide (KOH) mount is most frequently used for screening of cases and culture is the gold standard. KOH lacks sensitivity, and culture is time-consuming and technically demanding.

Aim, Settings, and Design:
A cross-sectional study was conducted at a tertiary care teaching institution. We aimed to use multiplex-PCR for faster and accurate identification of Malassezia spp directly from skin scrapings of suspected cases of PV.

Materials and Methods:
The study was conducted on suspected cases of PV over a period of 12 months. The clinical and demographic details were recorded. The skin scrapings were subjected to KOH mount and cultured on Sabouraud’s dextrose agar with an olive oil overlay. Multiplex-PCR targeting 11 Malassezia spp was performed on DNA extracted from skin scrapings.

Results:
A total of 69 suspected cases of PV were studied. Most patients belonged to metro cities and worked in hot and humid climates. The mean duration of lesions was 18 months, and most had macular and patchy lesions. The sensitivity of KOH and culture was found to be 82.6% and 91.3%, respectively. M. globosa (n = 60, 87%) and M. restricta (n = 3, 4.3%) were isolated in culture. Multiplex PCR detected 85.5% of M. globosa, 5.8% of M. restricta, and 8.7% of mixed infection with M. globosa and M. restricta. M-PCR detected Malassezia in all the samples.

Conclusions:
M-PCR could identify Malassezia species directly from skin specimens, eliminating the need for culture. M-PCR was accurate, dependable, and exhibited a rapid turnaround time.
Crown root ratio and angulation of various permanent teeth in patients with and without cleft lip/palate
Authors: Patel Dolly , Sinha Surina , Rupareliya Prerna , Guha Diptesh 
Published: September 2024

ABSTRACT

Aims and Objectives:
The purpose of this study was to analyze parameters of tooth in subjects with nonsyndromic cleft lip and palate (CLCP) and to compare the findings with the control groups. Teeth in the cleft-affected and nonaffected side in the same unilateral cleft lip and palate (ULCP) patient were also compared.

Materials and Methods:
The study included 200 subjects in the age group of 12–37 years who were divided into two groups: nonsyndromic CLCP and control group. The control group was further subdivided into skeletal Class I, II, and III subgroups based on ANB, AO-BO, and overjet, respectively. Crown height, root length, total tooth length, crown root ratio (C/R ratio), and tooth angulations of maxillary permanent central incisors, canines, 1st premolars, and 1st molar were measured on orthopantomograms using both ITK SNAP software and manual tracing.

Results:
Crown heights significantly increased while root lengths significantly decreased in the CLCP patients when compared to control groups. Total tooth lengths of central incisor, canine, and 1st premolar in CLCP patients were found to be decreased significantly. C/R ratios of all the teeth of nonsyndromic CLCP group irrespective of the cleft affected or nonaffected side was found to be increased as compared to the control groups. There was a significant difference seen in crown height, root length and mesiodistal tooth angulations in the cleft affected side when compared to the non affected side in a UCLCP patient’s dentition. However the total tooth length and the C/R ratio were not affected.

Conclusion:
Common findings of CLCP are aberrant teeth development, altered tooth morphology, and malformed teeth. The severity of cleft has an impact on the tooth development and morphology as it was observed that delayed root development and short roots, decreased total tooth length, increased C/R ratio and variations in teeth angulations in CLCP patients were affected by the presence and severity of cleft.