bluuebunny/crossref_metadata_2025_split huggingface dataset:
HCV genotype distribution in Istanbul: A detailed 7 year epidemiological overview and impact of Covid-19 pandemic
Authors: Erdin Begüm Nalça , Akkaya Yüksel , İrvem Arzu 
Published: October 2024

AbstractHepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. HCV has 8 genotypes (GT) and 86 subtypes and distribution of GTs varies based on geographical regions, transmission routes and even in cultural groups. The determination of viral genotype is crucial in choosing antiviral treatment, determining the duration of therapy, and monitoring treatment respose. Since 2014, with the usage of direct-acting antiviral agents (DAAs) in the treatment of HCV infections, a cure rate over 95% could be possible. Epidemiological data are important to combat a chronic HCV infections. Due to its geographical location, Turkey is like a bridge connecting Asia and Europe. Istanbul is the biggest and most crowded city of Turkey and has received immigration from many different countries, especially from Syria, in recent years and immigration still goes on. In addition, the COVID-19 pandemic has had devastating effects in our country. In this study, we determined the HCV genotypes in Health Sciences University Ümraniye Training and Research Hospital, in Istanbul between 2016 and 2022. Of the 322 patients analyzed during this 7-year period, HCV GT1b was the most prevalent GT in 65.2%, followed by GT3 in 15.5%, GT1a in 10.6%. Our data serve as a great mirror for HCV epidemiology in Turkey and contribute to global data.
The effect of different washing methods assisted by ultrasound on the removal of cypermethrin and spirotetramat residues in apples
Authors: Suyabatmaz Arzu Merve , Yakar Yasin 
Published: October 2024

AbstractThe simplest way to remove pesticide residues from fruits and vegetables is to wash them with tap water. However, this method is not effective enough. In this study, the effectiveness of different washing methods assisted by ultrasound on pesticide removal was investigated. For this purpose firstly, apples were soaked in a cypermethrin (CYP) and spirotetramat (SPI) solution, which are frequently used as insecticides. Subsequently, the apples were washed in solutions prepared with vinegar, lemon juice, and baking soda at different concentrations (0.5%, 1% and 2%) and assisted by ultrasound (2.5–5 min). The residues in the medicated and washed samples were analysed on an LC-MS/MS instrument after extraction using the QuEChERS extraction method. The results of the analysis showed that acidic vinegar and lemon juice were more effective than baking soda. Moreover, the application of ultrasound significantly increased this effect. When a 0.5% vinegar solution was assisted by ultrasound, 62% of the cypermethrin residue was removed and 82% of the spirotetramat residue was removed. These values were 51.5% and 49.6% higher than tap water, respectively. In conclusion, acidic solutions such as vinegar, which we can easily prepare at home, are highly effective in removing pesticide residues when assisted by ultrasound.
Fortification of yogurt with cloves extract: Quality characteristics, sensory attributes, and antioxidant evaluation
Authors: O. Aljobair Moneera 
Published: October 2024

The purpose of the current study was to evaluate the impact of different concentrations of clove extract (CE: 0%, 0.5%, 1.0%, and 2.0%) on the viscoelasticity, viscosity, syneresis, texture, sensory quality, and antioxidant properties of set yogurt up to 21 days in cold storage. The addition of CE enlarged the total suspended solids (TSS) and mineral contents while reducing whey separation. On the other hand, CE existence dropped the consistency index (k) and elastic modulus (G’) of yogurt gels and further lessening was observed with prolonged storage period. Moreover, the textural firmness remained unaffected whereas gels that are more cohesive were attained with integration of CE. Similarly, total phenolics and free radical scavenging activity increased significantly (p < 0.05) by CE supplementation, and amplified lipid oxidation was observed with increased storage time. Addition of CE lowered the lightness (L*) index and manipulated the organoleptic properties whereas the sample with 1% CE showed improvement in texture and flavor; however, the overall acceptability reduced for samples with higher concentration of CE.
Composite electrochemical coatings of Ni-CrB2 from sulfuric acid and sulfamate electrolytes: formation, structure and properties
Authors: Petukhova Polina , Bushueva Evdokiya , Novgorodtseva Oksana 
Published: October 2024

Electrodeposited coatings are in demand in many industries: due to the high adhesive strength to the base metal, they can be applied to complex-shaped products, and the thickness of the deposited coating can be controlled. However, standard electrolytic coatings do not always meet the necessary operating requirements. In this case, the formation of composite electrolytic coatings, which consist in the modification of electrolytes by various dispersed particles, becomes an urgent task. These particles are introduced into the electrolyte and deposited together with the precipitate metals, which leads to changes in the coating properties. In this article, the structure, adhesive and corrosion properties of nickel-chromium diboride composite coatings obtained in the electrodeposition process are studied. Precipitation was carried out in sulfuric acid and sulfamate electrolytes with a concentration of dispersed chromium diboride particles of 10-40 g/l. The coatings consist of nickel and CrB2 phases. The adhesive strength of the coating with a steel base is satisfactory; chipping and peeling were not observed. The corrosion resistance of sulfamate electrolyte coatings is higher than that of the coatings obtained from sulfuric acid electrolyte due to the compactness of nickel precipitates. Chromium diboride in the coating provides 1.5-2 times greater corrosion resistance.
Verbal triggers of positive emotions as a tool for forming the emotional component of schoolchildren’s value attitude towards other people
Authors: Savelyeva O. E. 
Published: October 2024

Importance. Building students’ value-based attitudes towards other people is an important goal of the modern educational process. This kind of attitude includes three aspects (cognitive, emotional and behavioural). The research focuses on the development of the emotional aspect of the valuebased attitude towards other people. The author analyses how verbal means affect people’s emotions and how these means can be used to create positive emotions in the process of building the emotional aspect of the value-based attitude towards other people in schoolchildren.Research Methods. The study uses an analytical review of the scientific and methodological literature on pedagogy; lexical, morphological and stylistic analyses of verbal structures are used.Results and Discussion. Verbal triggers are designed by the author in order to evoke positive emotions in schoolchildren towards the people around them. The examples of exercises with verbal triggers of tenderness and admiration for extra-curricular classes, or course on emotional intelligence, or as part of academic lessons, are also designed by the author.Conclusion. The research results can be used in the process of organising complex work on the formation of the emotional component of the value attitude towards people, as well as for further theoretical research on the issues of emotional learning and moral education in general.
Pedagogical support of persons with disabilities in physical education classes at university
Authors: Ivleva A. N. , Selivanov O. I. 
Published: October 2024

Importance. The research examines the characteristics of pedagogical support for persons with disabilities in physical education classes at university. The aim of the study is to analyse the characteristics of pedagogical support for persons with disabilities in physical education classes at university. In order to achieve this goal, a number of tasks have been solved. The definition of “pedagogical support for persons with disabilities” is analysed; a review of psychological and pedagogical literature on the research question is conducted; and methodological recommendations for pedagogical support of persons with disabilities in physical education classes at the university are developed.Materials and Methods. Analysis of theoretical and methodological literature on the research problem; analysis of the experience of practitioners working with persons with disabilities; comparative analysis; and the method of generalisation are used.Results and Discussion. Pedagogical support for persons with disabilities can be successfully organised in modern universities under a number of conditions detailed in the study.Conclusions. Competent and effective pedagogical support of persons with disabilities in physical education classes at the university allows persons with disabilities to integrate into the educational process as much as possible, as well as to compensate for health problems during physical education classes.
Linguodidactic and interdisciplinary analysis of the concept of mediation as a terminological problem
Authors: Chikrizova K. V. 
Published: October 2024

Importance. CEFR Companion Volume 2018 pays special attention to the development of four modes of communication (including mediation) along with the formation of communicative competence. The purpose of this research is to conduct an interdisciplinary analysis of the term “mediation” as well as to clarify this term in the Russian language.Materials and Methods. Research methods include analysis and interpretation of literature. The research materials are literature review of foreign and Russian scientists in the field of jurisprudence and law, philosophy, philosophy of religion, social philosophy, sociology, management, psychology, reflexive psychology, cultural-historical psychology, conflictology, linguistics, pedagogy, translation and translation studies, as well as linguodidactics.Result and Discussion. The concept of “mediation” is analyzed in various fields. The terminology in Russian for three types of mediation activities is clarified according to the CEFR Companion Volume 2018.Conclusion. In most scientific fields, mediation is viewed as a procedure involving three parties: two parties in conflict and one party acting as a neutral intermediary (mediator). However, in methodology of teaching foreign languages, the emphasis shifts to the fact that any student while developing his/her communicative competence, mastering four modes of communication, including mediation, can independently act as a mediator with any interlocutor or group of interlocutors.
Components of contemporary linguo-methodological competence of students in language training programs at the present stage
Authors: Murunov S. S. 
Published: October 2024

Importance. The competence-based approach prevailing in the current higher education puts forward special requirements to the systematization of knowledge and skills of graduates. The composition and description of professional competence, which is the main reference point in course design, has a strong impact on the overall effectiveness of the educational process, so there is an imperative need for a comprehensive and practice-oriented model of linguo-methodological competence. The purpose of the study is to develop a general model of linguo-methodological competence that meets the needs of linguo-methodological areas of training.Materials and Methods. To carry out the research: the corpus of research literature on the topic is analyzed, the general regularities of requirements to the competence of a specialist are synthesized and systematized, the structure of linguo-methodological competence is modeled.Results and Discussion. Interpretation of the general model of professional competence under specific conditions of foreign language teaching reveals a number of functionally different aspects of specialist’s competence. The following aspects are identified: behavioral, sociocultural, motivational, information and communication, and linguodidactic. Each component actualizes a relatively autonomous set of knowledge and skills, which can be purposefully influenced.Conclusion. The presented model is characterized by its structural completeness, which allows integrating private professional competences within the framework of individual components. The selected components reflect the main aspects of professional activity of a modern foreign language teacher, which allows us to use it as a starting point for designing a foreign language teacher training course.
Investigating Asphaltene Damage Reduction in Wellbores, and Pipelines Using Alkaline and Surfactant Chemical Agents
Authors: Elsayed Ali , Fakher Sherif 
Published: October 2024

Abstract
The oil and gas industry faces significant challenges due to asphaltene deposition, which can impede hydrocarbon flow and cause operational difficulties in wellbores and pipelines. This research investigates the efficacy of alkaline and surfactant chemical agents in reducing asphaltene damage. Experimental studies using various chemicals such as Sodium Lauryl Sulfate (SLS), heptane, xylene, water, and sodium bicarbonate reveal that the chemical agents’ effectiveness varies with concentration, offering insights into optimized strategies for managing asphaltene deposition. The findings contribute to developing more sustainable and effective solutions for the oil and gas industry.
Familial Risk and Interaction with Hypertension and Hyperglycemia in Primary Open-Angle Glaucoma
Authors: Kim Hyun Jung , Ahn Hyeong Sik , Swan Heather , Hong Gahwi , Lee Hee-Sang , Kazmi Sayada Zartasha , Kim Young Shin , Na Kun-Hoo , Eom Jungmin , Kang Taeuk , Cha Jaewoo , Hann Hoo Jae 
Published: October 2024

Abstract

Background/objectives: To quantify the familial risk of primary open-angle glaucoma (POAG) and estimate disease risk among individuals with a positive family history and either hypertension or hyperglycemia, as well as assess their interactions.
Subject/Methods: Using the National Health Insurance database, which includes information on familial relationships and lifestyle risk factors, we identified 6,217,057 individuals with first-degree relatives (FDRs) from 2002-2018. We calculated familial risk using hazard ratios (HRs) with 95% confidence intervals (CIs) which compare the risk of individuals with and without affected FDRs. Disease risk was estimated among individuals with both a positive family history and hypertension or hyperglycemia, and interactions were assessed on an additive scale.
Results: Individuals with an affected parent had a 3.13-fold (95% CI 2.74-3.58) increased risk of disease compared to those with unaffected parents. Individuals with affected father, mother, or both affected parents showed HRs (95% CI) of 3.50 (2.86-4.30), 2.87 (2.41-3.44) and 4.88 (1.83-12.98), respectively. Familial risk adjusted for lifestyle factors decreased slightly (HR 3.14), suggesting that genetic component is the predominant driver in the familial aggregation. Individuals with a positive family history and either hypertension or hyperglycemia had a markedly elevated risk of disease, with HRs of 3.42 (95% CI 2.49-4.69) and 3.27 (95% CI 2.15-4.97), respectively. For hypertension, their combined risk exceeded the sum of their individual risks, but statistically significant interactions were not observed.
Conclusions: Hypertensive or hyperglycemic individuals with a positive family history may be considered a high-risk group and glaucoma screening may be considered.
The performance of optic disc-macula distance to disc-diameter ratio in qualitative and quantitative assessment of the optic disc size
Authors: ISHIKAWA AKIRA , Kusaka Kazumi , Nakanishi Akane , Yokoyama Yu 
Published: October 2024

Abstract

Objectives
We aimed to evaluate the performance of the optic disc-macula distance to disc-diameter ratio (DM/DD) in qualitative and quantitative assessment of optic disc size.
Methods
In 300 apparently normal eyes, we determined the correlation between DM/DD and the planimetric disc area (DA) and evaluated the performance of DM/DD in discriminating between small and large discs. The ability of DM/DD to predict the actual DA was validated in a separate cohort of 200 eyes. The disc size in eyes with glaucoma or related diseases was compared with DA- or DM/DD-based disc size.
Results
The DM/DD and its square of inverse (DD2/DM2) showed excellent non-linear and linear correlations, respectively, with DA (p < 0.001 and p < 0.001, respectively), demonstrating their performance in discriminating between small (< 2.04 mm2) and large (> 2.94 mm2) disc sizes with an area under the receiver operating characteristic curve of 0.901 and 0.959, respectively. The difference between the predicted DA and planimetric DA was within ± 10% in more than 80% of the eyes. Eyes with suspected and normal-tension glaucoma exhibited larger discs (p < 0.01) when evaluated using both DM/DD and DA. The variation in disc-macula distance seemed to be a confounding factor for DM/DD in inferring the precise disc size.
Conclusion
DM/DD, which can be easily calculated from various kinds of fundus photographs or images, was an excellent and interchangeable tool for qualitative and quantitative assessment of disc size, which did not require correction for ocular magnification.
Should All Cervical Cancer Patients with Positive Lymph Node Receive Definitive Radiotherapy: A Population-Based Comparative Study
Authors: Ma Yue , Liu Xingyu , Wang Yang , Wang Danbo 
Published: October 2024

Abstract

Objective: The optimal initial treatment for lymph node metastases (LNM) cervical cancer remains a subject of controversy. This study aimed to investigate the association between surgery plus postoperative radiotherapy (PORT) and definitive radiotherapy (RT), and the prognosis of patients with LNM cervical cancer. Methods: Patients with positive lymph nodes (PLNs) in 2009 FIGO stage I-III cervical cancer were selected from SEER database. Kaplan-Meier and log-rank analysis were utilized to assess survival outcomes. Cox regression and Interaction analyses were used to compare the survival benefits. Results: 2936 patients were included in this study. Multivariate analysis revealed that the choice of primary treatment significantly influenced both cancer-specific survival (CSS) and overall survival (OS), serving as an independent prognostic factor for patients with LNM. After adjusting for imbalanced variables, surgery plus PORT significantly improved CSS and OS in the stage I-II and PLNs ≤ 5 subgroups. However, no significant difference was observed between the two treatment modalities in patients with stage III and PLNs > 5 subgroups. Through interaction analysis, it was observed that patients with stage I-II and PLNs ≤ 5 exhibited a significant survival benefit from surgery plus PORT. Conclusion: For cervical cancer patients at FIGO stage I-II or those with PLNs ≤ 5, combining surgery with PORT could lead to improved outcomes. However, this approach did not apply to those at stage III or individuals with PLNs > 5. Therefore, a comprehensive assessment of LNM and local tumor spread should guide rationalized treatment options when managing patients presenting LNM.
Efficacy of Adding Adductor Canal Block to Sciatic Nerve Block in Hallux Valgus Surgery
Authors: Polat Ezgi , Kocoglu Hasan , ozden mesure gul nihan , sarar serhan , uygur mehmet esat 
Published: October 2024

Abstract

Background
Optimal postoperative multimodal analgesia strategies were still under investigation in many orthopedic surgeries. The aims of this study were to determine the effects of adding the adductor canal block to the popliteal sciatic nerve block on sedation need, tourniquet pain, postoperative pain, and patient-surgeon satisfaction in patients operated for hallux valgus correction.
Methods
In this prospective, randomized, and controlled clinical trial, group S patients were performed only popliteal sciatic nerve block with 10 ml 0,5% bupivacaine and 10 ml 2% prilocaine in the prone position, group S + A were performed adductor canal block with 10 ml of 0,5% bupivacaine and 10 ml of 2% prilocaine with popliteal sciatic nerve block.
Results
Demographic data, duration of surgery, tourniquet time, surgeon satisfaction, complication rate, motor block time, time to first pain, first analgesic administration time and opioid consumption were similar between the two groups. Sensory and motor block onset time, tourniquet pain and additional sedation need rate were statistically significantly lower and patient satisfaction was significantly higher in Group S + A.
Conclusion
Adding the adductor canal block to the popliteal sciatic nerve block increases the quality of the peripheral nerve block and patient satisfaction with decreasing tourniquet pain and sedation need in hallux valgus correction surgery.
Extraintestinal manifestations may increase the risk of synchronous and metachronous development of other extraintestinal manifestations in Crohn’s disease
Authors: Ozkahraman Adnan , Kayar Yusuf , Dertli Ramazan , Konur Sevki , Kilic Guner , Baran Bulent , Ormeci Asli Ciftcibasi , Akyuz Filiz , Demir Kadir , Besisik Fatih , Kaymakoglu Sabahattin 
Published: October 2024

Abstract

In this study, we evaluated the relationship between the development of different types of EIM in CD. Patients with CD who were under regular follow-up from March 1986to October 2011 were included in our study. Accompanying EIMs and time of development were recorded. The frequency of EIMs and their association with each other were investigated. 336 patients with CD (55.4% male) with a mean follow-up duration of 7.54 years were included in the study. At the onset of CD diagnosis 21.1% of patients had at least one EIM. The prevalence of EIMs was 47.3% at 25-year follow-up.The prevalence of multiple EIMs was 12.2% and 22.9% at the onset of CD and at 25-year follow-up, resepectively. Oral, joint and skin involvement (32.4%, 24.7%, 9.2%, respectively) were the most common EIMs. The development of peripheral arthritis was a significantly associated with axial spondiloarthropathy, skin involvement, ocular involvement, oral ulcers, and vascular thromboembolism (p<0.05).There was significant relationship between oral ulcers and peripheral arthritis, axial arthritis, skin involvement, ocular involvement, liver involvement and thromboembolism (p<0.05).Development of EIMs in patients with CD may trigger development of other EIMs during the course of disease.