bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of perioperative pulmonary aspiration in children using quality assurance and hospital administrative billing data
Authors: Eisler Lisa , Huang Grace , Lee Ka‐Eun M. , Busse Jennifer A. , Sun Ming , Lin Albert Y. , Sun Lena S. , Ing Caleb 
Published: January 2018

SummaryBackgroundPerioperative aspiration is a rare but potentially devastating complication, occurring in 1‐10 per 10 000 anesthetics based on studies of quality assurance databases. Quality assurance reporting is known to underestimate the incidence of adverse outcomes, but few large studies use supplementary data sources. This study aims to identify the incidence of and risk factors for perioperative aspiration in children using quality assurance data supplemented by administrative billing records, and to examine the utility of billing data as a supplementary data source.MethodsAspiration events for children receiving anesthesia at a tertiary care pediatric hospital between 2008 and 2014 were identified using (i) a perioperative quality assurance database and (ii) hospital administrative billing records with International Classification of Diseases, Ninth Revision Clinical Modification coded diagnoses of aspiration. Records were subject to review by pediatric anesthesiologists. Following identification of all aspiration events, the incidence of perioperative aspiration was calculated and risk factors were assessed.Results47 272 anesthetic cases were evaluated over 7 years. The quality assurance database identified 20 cases of perioperative aspiration occurring in surgical inpatients, same‐day admissions, and outpatients. Using hospital administrative data (which excludes outpatients with shorter than a 24‐hour stay), 9 cases of perioperative aspiration were identified of which 6 had not been found through quality assurance data. Overall, International Classification of Diseases, Ninth Revision coding demonstrated a positive predictive value of 94.5% for any aspiration event; however, positive predictive value was <4% for perioperative aspiration. A total incidence of 5.5 perioperative aspirations per 10 000 (95% CI: 3.7‐8.0 per 10 000) anesthetics was found.ConclusionQuality assurance data offer an efficient way to measure the incidence of rare events, but may underestimate perioperative complications. International Classification of Diseases, Ninth Revision codes for aspiration used as a secondary data source were nonspecific for perioperative aspiration, but when combined with record review yielded a 30% increase in identified cases of aspiration over quality assurance data alone. The use of administrative data therefore holds potential for supplementing quality assurance studies of rare complications.
The prediction probabilities for emergence from sevoflurane anesthesia in children: A comparison of the perfusion index and the bispectral index
Authors: Liu Pei‐Pei , Wu Chi , Wu Jun‐Zheng , Zhang Ma‐Zhong , Zheng Ji‐Jian , Shen Yang , He Pan , Sun Ying 
Published: January 2018

SummaryBackgroundPredicting recovery of consciousness is one of the most essential functions of anesthesia depth monitors in anesthesia practice. Perfusion index and bispectral index are 2 indicators of the anesthesia depth monitoring with different working principles. The progression of the anesthesia emergence stages reflected by those monitors has not been well understood, especially in pediatric patients. The goals of this study were to compare the prediction probabilities of perfusion index and bispectral index in predicting awakening and in differentiating the different levels of arousal during emergence after sevoflurane anesthesia in children undergoing open inguinal hernia repairs.MethodsForty‐five patients, aged 1 to 5 years, ASA Status I or II and scheduled for elective open inguinal hernia repairs under general anesthesia were enrolled. The perfusion index and bispectral index were monitored simultaneously during anesthesia recovery. The University of Michigan Sedation Scale was applied to evaluate the clinical arousal levels during emergence. The prediction probability was used to assess the performance of perfusion index and bispectral index in predicting awakening and distinguishing different levels of arousal corresponding to the University of Michigan Sedation Scale during recovery.ResultsThe prediction probability of perfusion index (PkPI‐Awakening = .81, 95% CI 0.73‐0.89) in differentiating full consciousness from unconsciousness during recovery was comparable to that of bispectral index (PkBIS‐ Awakening = .86, 95% CI 0.79‐0.92) (P = .47). The prediction probability for perfusion index (PkPI‐UMSS = .61, 95% CI 0.55‐0.73) and bispectral index (PkBIS‐UMSS = .64, 95% CI 0.53‐0.69) had similar performance in distinguishing different University of Michigan Sedation Scale levels.ConclusionBoth the perfusion index and bispectral index performed comparably well in predicting awakening and different arousal levels when emerging from sevoflurane anesthesia in children.
Arabidopsis MLO2 is a negative regulator of sensitivity to extracellular reactive oxygen species
Authors: Cui Fuqiang , Wu Hongpo , Safronov Omid , Zhang Panpan , Kumar Rajeev , Kollist Hannes , Salojärvi Jarkko , Panstruga Ralph , Overmyer Kirk 
Published: January 2018

AbstractThe atmospheric pollutant ozone (O3) is a strong oxidant that causes extracellular reactive oxygen species (ROS) formation, has significant ecological relevance, and is used here as a non‐invasive ROS inducer to study plant signalling. Previous genetic screens identified several mutants exhibiting enhanced O3 sensitivity, but few with enhanced tolerance. We found that loss‐of‐function mutants in Arabidopsis MLO2, a gene implicated in susceptibility to powdery mildew disease, exhibit enhanced dose‐dependent tolerance to O3 and extracellular ROS, but a normal response to intracellular ROS. This phenotype is increased in a mlo2 mlo6 mlo12 triple mutant, reminiscent of the genetic redundancy of MLO genes in powdery mildew resistance. Stomatal assays revealed that enhanced O3 tolerance in mlo2 mutants is not caused by altered stomatal conductance. We explored modulation of the mlo2‐associated O3 tolerance, powdery mildew resistance, and early senescence phenotypes by genetic epistasis analysis, involving mutants with known effects on ROS sensitivity or antifungal defence. Mining of publicly accessible microarray data suggests that these MLO proteins regulate accumulation of abiotic stress response transcripts, and transcript accumulation of MLO2 itself is O3 responsive. In summary, our data reveal MLO2 as a novel negative regulator in plant ROS responses, which links biotic and abiotic stress response pathways.
Use of antiviral medications in drug reaction with eosinophilia and systemic symptoms (DRESS): A case of infantile DRESS
Authors: Chow Maggie L. , Kim David , Kamath Sonia , Peng David , Luu Minnelly 
Published: January 2018

AbstractA 3‐month‐old girl with Sturge‐Weber syndrome presented with a morbilliform rash, eosinophilia, and fulminant liver failure to our tertiary pediatric hospital. She was diagnosed with drug reaction with eosinophilia and systemic symptoms complicated by viremia and evidence of viral hepatitis on liver biopsy. We discuss the role of viral reactivation in drug reaction with eosinophilia and systemic symptoms and the relevance of antiviral therapy in management.
Severe ectropion in lamellar ichthyosis managed medically with oral acitretin
Authors: Singh Manpreet , Kaur Manpreet , Kaur Ripanjeet , Singh Shakeen 
Published: January 2018

AbstractCongenital ectropion is commonly associated with lamellar ichthyosis. Severe eyelid ectropion may cause corneal exposure, keratopathy, and permanent corneal scarring. We report a neonate with severe, bilateral, congenital ectropion and eclabium managed using oral retinoids. Both corneas were protected with topical antibiotics and lubricating eyedrops and eye ointments. At 12‐month follow‐up, the child was doing well, with no ectropion or corneal opacity.
Policy Expansion in Local Government Environmental Policy Making
Authors: Arnold Gwen , Long Le Anh Nguyen 
Published: January 2018

AbstractRelatively little is known about when, why, and how some jurisdictions “double down” on policy priorities, rapidly adopting multiple measures tackling the same issue. Rapid policy expansion can emerge in fast‐evolving, uncertain, and contested policy arenas in which pressures for policy making are not satisfied, and even may be strengthened, by initial policy innovation. This article analyzes local government policy making on high‐volume hydraulic fracturing by New York State municipalities from 2008 to 2012. Policy path dependence, peer influence, and policy design appear to play a critical role in determining whether public officials respond to these pressures with policy expansion. Initial policy innovations can open windows for policy participants to secure additional measures that strengthen or enlarge the scope of action. Public officials and stakeholders seeking particular policy outcomes should take a long view of the policy process while simultaneously remaining alert for opportunities afforded by pressurized policy dilemmas.
Validation of a portable monitor for assessment of cerebrospinal fluid lactate in dogs
Authors: Nye Carolyn J. , Mariani Christopher L. 
Published: January 2018

BackgroundCerebrospinal fluid (CSF) lactate concentration may be a useful diagnostic and prognostic biomarker in dogs. Previous studies have used methods requiring relatively large sample volumes or prolonged storage prior to analysis. An effective method to immediately quantify lactate in smaller CSF volumes would be beneficial.ObjectivesThe main objectives were to evaluate the utility, accuracy, and precision of a portable meter for CSF lactate analysis in dogs and to develop a provisional RI using this device. A secondary objective was to assess the effects of different storage conditions on lactate concentrations.MethodsThe Lactate Plus device was used to analyze CSF samples. Device accuracy and precision were assessed by spiking CSF samples with concentrated sodium lactate solutions and by repeated analysis of samples, respectively. The provisional RI was generated using CSF samples from dogs with unremarkable laboratory data, central nervous system imaging, and conventional cytologic and chemical CSF analysis. Select samples were analyzed before and after storage at 4°C, −20°C, and −80°C.ResultsSpiked samples showed lactate concentrations comparable to expected concentrations. The CV of immediate repeated measurements was 0–9.69%. Sample storage at 4°C for 24 hours showed similar results but variation was higher with other storage conditions. The provisional RI was 1.02–2.49 mmol/L.ConclusionsThe Lactate Plus has acceptable accuracy and precision for the quantification of CSF lactate in dogs. Lactate in CSF is ideally quantified immediately after collection as a subset of samples show variation with storage although most stored samples show acceptable variation.
Citrus Flavor Technologies: Citrus Oils — Processing, Separation, Application
Authors: Berdis Elizabeth , Buckley John , Kraft John 
Published: January 2018

Citrus flavors play a significant role in the beverage industry. Citrus-based beverages and those containing citrus flavor components lead the flavor category for beverages today. The essential oils used in flavors are obtained during fruit juice processing. In order to process these essential oils for flavor applications, various separation technologies are used.
The purpose of this paper is to present an overview of various aspects of citrus flavor technology. It will give a brief review of factors that affect oil quality during processing operations. Basic distillation principles and factors affecting distillation are presented as well as flavor application, separation technology and alternative process technologies.
Paper published with permission.
Successful CIP Cleaning
Authors: Vaughn Cliff 
Published: January 2018

Cleaning and sanitation play key roles in ensuring that the final product from the manufacturing process achieves the desired quality standard. Clean-in-place (CIP) is becoming common in food, beverage, and dairy facilities as the most cost effective method for cleaning. This paper will provide a concise overview of the operation and principles of CIP cleaning, an introduction into managing equipment fouling, and the role that cleaning chemicals play in the cleaning process.
Paper published with permission.
Commercial Ethanol Production From Cellulosic Biomass in South Florida
Authors: Evans Craig 
Published: January 2018

Alico Energy, LLC, a subsidiary of Alico, Inc., has been awarded a grant from the State of Florida under the Florida Energy Act and a grant and loan guarantee from the U.S. Department of Energy to construct one of the nation’s first cellulosic ethanol facilities in South Florida. The Alico Energy biorefinery will be capable of co-producing ethanol and electricity from any carbon-based feedstock or waste, including citrus peel, and trimmings from citrus trees. The initial plant will produce only ethanol. The capacity to produce electricity will be added at a later date.
Paper published with permission.
Early Clinical Assessment of the Antimicrobial Activity of Finafloxacin Compared to Ciprofloxacin in Subsets of Microbiologically Characterized Isolates
Authors: Vente Andreas , Bentley Christine , Lückermann Mark , Tambyah Paul , Dalhoff Axel 
Published: January 2018

ABSTRACT

Two phase II studies were performed with patients with uncomplicated urinary tract infections (uUTIs) and complicated urinary tract infections (cUTIs) or acute pyelonephritis (PN) to compare finafloxacin (300 mg twice a day [b.i.d.] orally for uUTI and 800 mg once a day [q.d.] intravenously [i.v.] for cUTI/PN) and ciprofloxacin (250 mg b.i.d. orally for uUTI and 400 mg b.i.d. i.v. for cUTI/PN). The early response to the study medications was evaluated in the microbiological intent-to-treat population (mITT) at day 3. A total of 21% of the isolates were ciprofloxacin resistant, 13.7% were primed pathogens carrying a mutation(s) potentially fostering fluoroquinolone resistance development, and 7.1% produced extended-spectrum β-lactamases (ESBLs). Finafloxacin demonstrated very good early clinical activity, with microbiological eradication rates of 88.6% (
n
= 132), compared to 78.7% (
n
= 61) for ciprofloxacin, and 69.6% (
n
= 23), compared to 35.7% (
n
= 14) for ciprofloxacin, in patients with ciprofloxacin-resistant uropathogens; 94.1% (
n
= 17), compared to 80.0% (
n
= 10) for ciprofloxacin, in patients infected with uropathogens primed for fluoroquinolone resistance uropathogens; and 91.7% (
n
= 11), compared to 0% for ciprofloxacin, in patients infected with ESBL producers. Finafloxacin demonstrated early and rapid activity against uropathogens, including fluoroquinolone-resistant and/or multiresistant pathogens or ESBL producers, while ciprofloxacin was less active against this subset of resistant pathogens. Susceptibilities of pathogens were quantitated by broth microdilution. Isolates were subgrouped according to their susceptibility patterns, in particular first-step quinolone resistance, quinolone resistance, and ESBL production. Eradication was defined as the elimination or reduction of study entry pathogens to <10
3
CFU/ml in urine culture. (The studies described in this paper have been registered at ClinicalTrials.gov under identifiers NCT00722735 and NCT01928433.)
Draft Genome Sequences of Phenotypically Distinct
Janthinobacterium
sp. Isolates Cultured from the Hudson Valley Watershed
Authors: Bettina Alexandra M. , Doing Georgia , O’Brien Kelsey , Perron Gabriel G. , Jude Brooke A. 
Published: January 2018

ABSTRACT

Investigation of the Hudson Valley watershed reveals many violacein-producing bacteria. These are of interest for their biotherapeutic potential in treating chytrid infections of amphibians. The draft whole-genome sequences for seven
Janthinobacterium
isolates with a variety of phenotypes are provided in this study.
Draft Genome Sequence of the Crude Oil-Degrading and Biosurfactant-Producing Strain
Cobetia
sp. QF-1
Authors: Guo Ping , Cao Binxia , Qiu Xue , Lin Jianguo 
Published: January 2018

ABSTRACT

We report here the draft genome of
Cobetia
sp. QF-1, a cold-adapted bacterium isolated from crude oil-contaminated seawater of the Yellow Sea, China. This genome is approximately 4.1 Mb (G+C content, 57.44%) with 3,513 protein-coding sequences.
Cobetia
sp. QF-1 shows crude oil degradation and biosurfactant production activity at low temperature.
Draft Genome Sequence of
Bacillus subtilis
2C-9B, a Strain with Biocontrol Potential against Chili Pepper Root Pathogens and Tolerance to Pb and Zn
Authors: Muñoz-Moreno Claudia Y. , De La Cruz-Rodríguez Yumiko , Vega-Arreguín Julio , Alvarado-Rodríguez Miguel , Gómez-Soto José Manuel , Alvarado-Gutiérrez Alejandro , Fraire-Velázquez Saúl 
Published: January 2018

ABSTRACT

Bacillus subtilis
2C-9B, obtained from the rhizosphere of wild grass, exhibits inhibition against root rot causal pathogens in
Capsicum annuum
, Pb and Zn tolerance, and plant growth promotion in medium supplemented with Pb. The genome of
B. subtilis
2C-9B was sequenced and the draft genome assembled, with a length of 4,215,855 bp and 4,723 coding genes.
Exploring the (Almost) Unknown: Archaeal Two-Component Systems
Authors: Krell Tino 
Published: January 2018

ABSTRACT

Two-component systems (TCS) exist in bacteria and archaea. In contrast to the knowledge of bacterial TCSs, little information is available on their archaeal counterparts. In the current issue of
Journal of Bacteriology
, Galperin and coworkers present a bioinformatics analysis of TCS genes from archaeal genome sequences (M. Y. Galperin, K. S. Makarova, Y. I. Wolf, and E. V. Koonin, J Bacteriol 200:e00681-17, 2018,
https://doi.org/10.1128/JB.00681-17
). This study identifies different aspects in which TCS-mediated signaling differs in bacteria and archaea and forms a sound basis for the experimental design of studies to increase our knowledge of this poorly investigated protein family.
Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis
Authors: Lee Hye-Ra , Li Fan , Choi Un Yung , Yu Hye Ryun , Aldrovandi Grace M. , Feng Pinghui , Gao Shou-Jiang , Hong Young-Kwon , Jung Jae U. 
Published: January 2018

ABSTRACT

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi’s sarcoma (KS), which is one of the most common HIV-associated neoplasms. The endothelium is the thin layer of squamous cells where vascular blood endothelial cells (BECs) line the interior surface of blood vessels and lymphatic endothelial cells (LECs) are in direct contact with lymphatic vessels. The KS lesions contain a prominent compartment of neoplastic spindle morphology cells that are closely related to LECs. Furthermore, while KSHV can infect both LECs and BECs
in vitro
, its infection activates genetic programming related to lymphatic endothelial cell fate, suggesting that lymphangiogenic pathways are involved in KSHV infection and malignancy. Here, we report for the first time that viral interferon regulatory factor 3 (vIRF3) is readily detected in over 40% of KS lesions and that vIRF3 functions as a proangiogenic factor, inducing hypersprouting formation and abnormal growth in a LEC-specific manner. Mass spectrometry analysis revealed that vIRF3 interacted with histone deacetylase 5 (HDAC5), which is a signal-responsive regulator for vascular homeostasis. This interaction blocked the phosphorylation-dependent cytosolic translocation of HDAC5 and ultimately altered global gene expression in LECs but not in BECs. Consequently, vIRF3 robustly induced spindle morphology and hypersprouting formation of LECs but not BECs. Finally, KSHV infection led to the hypersprouting formation of LECs, whereas infection with a ΔvIRF3 mutant did not do so. Collectively, our data indicate that vIRF3 alters global gene expression and induces a hypersprouting formation in an HDAC5-binding-dependent and LEC-specific manner, ultimately contributing to KSHV-associated pathogenesis.

IMPORTANCE
Several lines of evidences indicate that KSHV infection of LECs induces pathological lymphangiogenesis and that the results resemble KS-like spindle morphology. However, the underlying molecular mechanism remains unclear. Here, we demonstrated that KSHV vIRF3 is readily detected in over 40% of various KS lesions and functions as a potent prolymphangiogenic factor by blocking the phosphorylation-dependent cytosolic translocation of HDAC5, which in turn modulates global gene expression in LECs. Consequently, vIRF3-HDAC5 interaction contributes to virus-induced lymphangiogenesis. The results of this study suggest that KSHV vIRF3 plays a crucial role in KSHV-induced malignancy.
Limited recycling of crustal osmium in forearc mantle during slab dehydration
Authors: Liu Chuan-Zhou , Xu Yang , Wu Fu-Yuan 
Published: January 2018

Abstract
Elevated 187Os/188Os ratios compared to ambient oceanic mantle, i.e., 187Os/188Os &gt; 0.13, have been reported for both arc lavas and mantle wedge xenoliths, which have been attributed to the addition of crustal Os through slab dehydration or melting. By contrast, much lower 187Os/188Os ratios of spinels from Izu-Bonin-Mariana (western Pacific Ocean) boninites indicate that slight or no crustal Os was transferred from the slab to the forearc mantle. Here we report Os isotopic compositions of peridotites from New Caledonia (southwest Pacific Ocean) ophiolites, which represent relics of a forearc mantle. Some New Caledonia peridotites are characterized by Os concentrations of &lt;1 ppb, yet have 187Os/188Os ratios comparable to those of the ambient oceanic mantle (i.e., 187Os/188Os &lt; 0.13). This confirms that little crustal Os was transported to the forearc mantle via slab dehydration. Contrasting Os isotopes between forearc peridotites and mantle wedge xenoliths may reflect the changing behavior of Os in diverse agents released from the descending slab as a function of depth; this is mainly controlled by the stability of sulfides in the slabs. During dehydration at shallow depths, sulfides keep stable and thus little Os is transported to the overlying mantle. In comparison, sulfides become unstable and tend to break down at deeper depths where slab melting or supercritical fluid generation occurs, and thus Os behaves like a mobile element.