bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of an in‐network lake on the timing, form, and magnitude of downstream dissolved organic carbon and nutrient flux
Authors: Kalinin Alexey , Covino Tim , McGlynn Brian 
Published: October 2016

AbstractWithin fluvial networks, lakes can be sinks or sources of dissolved organic carbon (DOC) and nutrients, yet the controls over sink‐source behavior remain unclear. We investigated the influence that an in‐network lake exerted on DOC and nutrient export. Our investigation consisted of: (1) injecting a conservative tracer to determine lake travel times and flow paths; (2) sampling lake inflow, outflow, and surrounding groundwater to determine water and nutrient budgets; and, (3) sampling internal lake profiles to ascertain in‐lake physico‐chemical patterns through time. Conservative tracer data indicated considerable in‐lake retention and combined with inflow‐outflow discharge measurements revealed a decoupling of kinematic and solute pulses. Nitrate (NO3) was the dominant form of dissolved inorganic nitrogen (DIN) at lake inflow whereas ammonium (NH4) became the dominant component at lake outflow. The lake was a sink for NO3‐N and PO4, but a source for NH4‐N, DON, TDN, and DOC. We observed hydrologic controls on DOC concentrations and export patterns, but redox controls on DIN dynamics. Our results indicate that lakes within fluvial networks can be sources of dissolved organic material and reduced nitrogen (NH4) while simultaneously being sinks for NO3‐N and PO4‐P. Determining controls on sink‐source behavior and the cumulative effect of lakes on DOC and nutrient budgets is a necessary first step toward improved understanding of the role of lakes in network‐ to regional‐scale dynamics.
Rescaling the complementary relationship for land surface evaporation
Authors: Crago R. , Szilagyi J. , Qualls R. , Huntington J. 
Published: October 2016

AbstractRecent research into the complementary relationship (CR) between actual and apparent potential evaporation has resulted in numerous alternative forms for the CR. Inspired by Brutsaert (2015), who derived a general CR in the form y = function (x), where x is the ratio of potential evaporation to apparent potential evaporation and y is the ratio of actual to apparent potential evaporation, an equation is proposed to calculate the value of x at which y goes to zero, denoted xmin. The value of xmin varies even at an individual observation site, but can be calculated using only the data required for the Penman (1948) equation as expressed here, so no calibration of xmin is required. It is shown that the scatter in x‐y plots using experimental data is reduced when x is replaced by X = (x − xmin)/(1 − xmin). This rescaling results in data falling along the line y = X, which is proposed as a new version of the CR. While a reinterpretation of the fundamental boundary conditions proposed by Brutsaert (2015) is required, the physical constraints behind them are still met. An alternative formulation relating y to X is also discussed.
Secular trends of physical growth and abdominal adiposity of school children and adolescents living at a moderate altitude in Peru
Authors: Cossio‐Bolaños Marco , de Arruda Miguel , Andruske Cynthia Lee , Luarte‐Rocha Cristian , Gómez‐Campos Rossana 
Published: October 2016

AbstractObjectiveIdentify changes in physical growth and abdominal adiposity at an interval of 14 years in children and adolescents living at a moderate altitude in Peru.Materials and MethodsThe data comes from two cross‐sectional studies carried out in the city of Arequipa, Peru, located at a moderate altitude of 2,320 meters. In 2001, 473 males and 482 females were assessed, and in 2015, 432 males and 403 females between 6.0 and 12.9 years old were evaluated. Data were collected in public state schools and measured using the anthropometric variables for weight, height, and waist circumference. Body mass index (BMI) was calculated according to age and sex.ResultsPositive trends for weight were identified for both males and females at all ages (p < .001). For height, significant increases were observed in males for all ages. No significant increases (p > .05) occurred in height for females between the ages of 6 and 8 years. However, commencing at age 9 until 12 years, females showed positive and significant increases (p < .001) in height. In 2015, BMI and waist circumference increased significantly for both sexes at all ages.DiscussionBetween 2001 and 2015, positive trends in physical growth and abdominal adiposity were identified for children and adolescents living in Arequipa, Peru. These changes may be associated with the rapid economic development in the country.
A composite approach for remediation of cane distillery spent wash using chitosan modified biomass, electrolysis, and Oscillatoria boryana
Authors: Venkatachalam Dhanapal , Kaliappa Gounder Subramanian 
Published: October 2016

ABSTRACTA cost effective multistep bio‐physicochemical method comprising adsorption on carbon, banana pseudo‐stem (BPS), and modified chitosan hydrogels (MHPS) as adsorbents, bioremediation using Oscillatoria boryana (OB) and constant current electrolysis was employed successfully to remove oxygen demanding organic wastes, color, total dissolved solids (TDS), melanoidin, and acidic/basic impurities from distillery spent wash (DSW). The adsorbent were characterized for their structures [Shimadzu FTIR (Fourier transform–Infrared spectroscopy)−8400S], thermal stability [TGA (Thermogravimetric analyzer)‐Q 500 V20.0 Build 36] and surface morphology [ZEISS EVO series SEM (Scanning Electron Microscopy)‐EVO 50]. The percentage color reduction by visible spectrometry and residual coloring matter on platinum–cobalt color unit scale were found to be 97.2% and 250 ppm, respectively till OB bioremediation stage. The remaining residual color (2.8%) was removed in the subsequent electrolysis (1.95%) and adsorption on MHPS (0.85%) stages. The net percent reduction in color (>99%), COD (Chemical Oxygen Demand) and BOD (Biochemical Oxygen Demand) in the present composite approach for DSW treatment were found to be much higher than the reported values. Analysis of the adsorption data for the synthesized activated carbon through Langmuir and Freundlich isotherm models revealed Langmuir adsorption isotherm with pseudo‐ first‐order kinetics. The evaluated thermodynamic parameters (Van't Hoff plot) for adsorption revealed that the adsorption was spontaneous and exothermic. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44546.
Curing kinetics, thermal, and adhesive properties of acetylene‐terminated benzoxazine
Authors: Liu Caizhao , Sun Mingming , Zhang Bin , Zhang Xugang , Li Jianhui , Li Qili 
Published: October 2016

ABSTRACTThe acetylene‐terminated benzoxazine monomer (BB‐apa) has been synthesized using 2,2‐bis(4‐hydroxyphenyl)butane, 3‐aminophenylacetylene, and paraformaldehyde. The structure of the monomer was characterized by FTIR spectroscopy and 1H NMR spectra, which indicated that the reactive oxazine ring and acetenyl groups existed in molecular structure of BB‐apa. The polymerization behavior was monitored by FTIR and non‐isothermal differential scanning calorimetry (DSC), which showed that the BB‐apa had completely cured with multiple polymerization mechanisms according to oxazine ring‐opening and ethynyl addition polymerization. The curing kinetics results revealed that the introduction of ethynyl groups can accelerate the ring‐opening polymerization of benzoxazine, leading to a lower curing temperature and apparent activation energy. Moreover, the thermoset derived from the BB‐apa exhibits higher thermal stability and lap shear strength (at 350 °C) with the glass transition temperature of 353 °C compared with the traditional benzoxazine polymer without ethynyl groups (BB‐a). © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44547.
Randomized clinical trial of sacral nerve stimulation for refractory constipation
Authors: Zerbib F , Siproudhis L , Lehur P-A , Germain C , Mion F , Leroi A-M , Coffin B , Le Sidaner A , Vitton V , Bouyssou-Cellier C , Chene G , Zerbib F , Simon M , Denost Q , Lepicard P , Lehur P-A , Meurette G , Wyart V , Kubis C , Mion F , Roman S , Damon H , Barth X , Leroi A-M , Bridoux V , Gourcerol G , Coffin B , Castel B , Gorbatchef C , Le Sidaner Anne , Mathonnet M , Vitton V , Lesavre N , Orsoni P , Siproudhis L , Brochard C , Desfourneaux V 
Published: October 2016

Abstract

Background
Open studies have reported favourable results for sacral nerve stimulation in the treatment of refractory constipation. Here, its efficacy was assessed in a double-blind crossover RCT.

Methods
Patients with at least two of the following criteria were included: fewer than three bowel movements per week; straining to evacuate on more than 25 per cent of attempts; or sensation of incomplete evacuation on more than 25 per cent of occasions. Response to therapy was defined as at least three bowel movements per week and/or more than 50 per cent improvement in symptoms. Responders to an initial 3-week peripheral nerve evaluation were offered permanent implantation of a pulse generator and were assigned randomly in a crossover design to two 8-week intervals of active or sham stimulation. At the end of the two trial periods, the patients received active stimulation until the final evaluation at 1 year.

Results
Thirty-six patients (34 women; mean(s.d.) age 45(14) years) underwent peripheral nerve evaluation. Twenty responded and received a permanent stimulator. A positive response was observed in 12 of 20 and 11 of 20 patients after active and sham stimulation periods respectively (P = 0·746). Pain related to the device occurred in five patients and wound infection or haematoma in three, leading to definitive removal of the pulse generator in two patients. At 1 year, 11 of the 20 patients with an implanted device continued to respond. Stimulation had no significant effect on colonic transit time.

Conclusion
These results do not support the recommendation of permanent implantation of a pulse generator in patients with refractory constipation who initially responded to temporary nerve stimulation. Registration number: NCT01629303 (http://www.clinicaltrials.gov).
Traumatic brain injury among female offenders in a prison population: results of the FleuryTBI study
Authors: Durand Eric , Watier Laurence , Lécu Anne , Fix Michel , Weiss Jean‐Jacques , Chevignard Mathilde , Pradat‐Diehl Pascale 
Published: October 2016

AbstractAimThe study was designed to estimate the prevalence of traumatic brain injury (TBI) in a French prison population of female offenders, study the variables known to be associated with TBI, and compare our results with those obtained among male offenders as described in a previous paper.ParticipantsAll female offenders (adults and juveniles) consecutively admitted to Fleury‐Mérogis prison over a 3‐month period were included in the study.MethodDuring the admission procedure, female offenders were interviewed by healthcare staff using a self‐reported questionnaire.ResultsIn all, 100 female offenders were included. The rate of self‐reported TBI was high, with a prevalence of 21%. The first cause of TBI was violence related (35%) and a majority of female offenders with a history of TBI reported having sustained more than one TBI. When compared with those who did not report a TBI, epilepsy and use of alcohol were higher among female offenders with a history of TBI. Perceived health was significantly worse for women who reported a TBI.ConclusionsThis study findings provide additional evidence that TBI among offender populations is serious and that specific actions need to be developed and implemented in correctional settings such as screening for TBI upon arrival.
Elevated cerebrospinal fluid uric acid during relapse of neuromyelitis optica spectrum disorders
Authors: Shu Yaqing , Li Haiyan , Zhang Lei , Wang Yuge , Long Youming , Li Rui , Qiu Wei , Lu Zhengqi , Hu Xueqiang , Peng Fuhua 
Published: October 2016

AbstractIntroductionPrevious studies have shown that serum uric acid (UA) modulates outcomes of neurological diseases, although little is known about cerebrospinal fluid (CSF) UA levels in neuromyelitis optica spectrum disorders (NMOSDs).MethodsCerebrospinal fluid and serum UA levels were measured in samples from 68 patients, including NMOSDs during relapse (n = 38) and controls with noninflammatory and non‐neurodegenerative diseases (CTLs, n = 30). Correlation analysis was performed between CSF UA and clinical characteristics, serum UA, and blood–brain barrier integrity in NMOSDs.ResultsCerebrospinal fluid UA levels in NMOSDs were significantly higher than in CTLs (p = .002), while serum UA differences between NMOSDs and CTLs were not statistically significant. In NMOSDs, CSF UA levels were significantly higher in patients with an impaired blood–brain barrier than in patients with an intact one (p < .001), and significantly higher in longer disease duration than in shorter disease duration patients (p = .002). CSF UA levels were also significantly higher in active patients upon MRI than in inactive patients (p < .001), and significantly higher in patients with brain lesions than without brain lesions (p = .024). CSF UA was significantly associated with the serum UA levels (r = .454, p = .002), disease duration (r = .383, p = .018), and blood–brain barrier index (r = .805, p < .001), but did not correlate with age, gender, annualized relapse rate, duration, or severity of NMOSD. Multiple regression analysis demonstrated that CSF UA was independent of the blood–brain barrier index (β = .765, p < .001) and serum UA levels (β = .01, p = .019) in NMOSDs.ConclusionsCerebrospinal fluid UA levels were elevated in NMOSD patients during relapse, and were likely modified by serum UA levels and blood–brain barrier integrity.
NRG1 fusion in a French cohort of invasive mucinous lung adenocarcinoma
Authors: Duruisseaux Michaël , McLeer‐Florin Anne , Antoine Martine , Alavizadeh Sanaz , Poulot Virginie , Lacave Roger , Rabbe Nathalie , Cadranel Jacques , Wislez Marie 
Published: October 2016

AbstractInvasive mucinous lung adenocarcinoma (IMA) is a rare subtype of lung adenocarcinoma with no effective treatment option in advanced disease. KRAS mutations occur in 28–87% of the cases. NRG1 fusions were recently discovered in KRAS‐negative IMA cases and otherwise negative for known driver oncogenes and could represent an attractive therapeutic target. Published data suggest that NRG1 fusions occur essentially in nonsmoking Asian women. From an IMA cohort of 25 French patients of known ethnicity, driver oncogenes EGFR, KRAS, BRAF, ERBB2 mutations, and ALK and ROS1 rearrangements presence were analyzed. In the IMA samples remaining negative for these driver oncogenes, an NRG1 rearrangement detection was performed by FISH. A driver oncogene was identified in 14/25 IMA, namely 12 KRAS mutations (48%), one ROS1 rearrangement (4%), and one ALK rearrangement (4%). The detection of NRG1 rearrangement by FISH was conducted in the 11 pan‐negative IMA. One sample was NRG1FISH‐positive and 100% of the tumor nuclei analyzed were positive. This NRG1‐positive patient was a 61‐year‐old nonsmoking woman of Vietnamese ethnicity and was the sole patient of Asian ethnicity of the cohort. She died 6 months after the diagnosis with a pulmonary multifocal disease. NRG1FISH detection should be considered in patients with IMA pan‐negative for known driver oncogenes. These results might suggest that NRG1 fusion is more frequent in IMA from Asian patient. Larger studies are needed.
Epidermal growth factor receptor and notch signaling in non‐small‐cell lung cancer
Authors: Pancewicz‐Wojtkiewicz Joanna 
Published: October 2016

AbstractLung cancer is the most common reason of cancer deaths and about 85% of these are non‐small‐cell lung cancer. Currently, lung cancer therapy is mainly based on the tumor node metastasis (TNM) disease staging and tumor histological classification. Despite therapeutic innovations, the prognosis for lung cancer patients has not significantly changed in the last years. Therefore, a proper understanding of cell signaling pathways involved in cancer pathogenesis seems to be essential for improvement in cancer therapy field. The knowledge of crosstalk between epidermal growth factor receptor (EGFR) and Notch pathway can lead to enhanced screening for the expression of these genes allowing patients to optimize treatment options and predict potential treatment resistance. This review focuses on recent advances related to the mechanisms of EGFR and Notch signaling in non‐small‐cell lung cancer and the effectiveness of current Notch‐ and EGFR‐targeted therapies.
Developing a model of working with worry in emotion‐focused therapy: A discovery‐phase task analytic study
Authors: Murphy Jennifer , Rowell Lucy , McQuaid Anne , Timulak Ladislav , O'Flynn Rosie , McElvaney James 
Published: October 2016

AbstractBackgroundGeneralised anxiety disorder (GAD) is an anxiety disorder characterised by excessive anxiety and worry. Worry is seen as a key‐defining feature of GAD. Several cognitive‐behavioural models of working with worry in GAD exist. More recently, there have been efforts to adapt emotion‐focused therapy (EFT) for GAD. This study focused on task analysis, observing therapist and client processes (using qualitative observations as well as observer‐used measures) in the clinically developed, two‐chair dialogue for worry (an intervention inspired by a similar EFT task of working with self‐criticism in depression).MethodA task analysis methodological approach was applied to 34 worry dialogues from eight clients. The worry dialogues were qualitatively analysed, focusing on therapist and client processes in the task and also using observer‐based measures such as Classification of Affective‐Meaning States, Client Emotion Arousal Scale and Client Emotion Productivity Scale.ResultsA tentative model of worry transformation using the two‐chair dialogue for worry is presented. The model consists of marker identification, enactment of the worry, deepening the toll of the worry, articulation of the need towards the worry and the worry softening or the client's standing up to the worry. The results also focus on the progression in the dialogues across the series of dialogues.ImplicationsThe model has an immediate practical application as it can inform therapists' actions when working with worry processes in GAD clients. Implications for future research are also discussed.
Biocidal Compounds from Mentha sp. Essential Oils and Their Structure–Activity Relationships
Authors: Kimbaris Athanasios C. , González‐Coloma Azucena , Andrés Maria Fe , Vidali Veroniki P. , Polissiou Moschos G. , Santana‐Méridas Omar 
Published: October 2016

Essential oils from Greek Mentha species showed different chemical compositions for two populations of M. pulegium, characterized by piperitone and pulegone. Mentha spicata essential oil was characterized by endocyclic piperitenone epoxide, piperitone epoxide, and carvone. The bioactivities of these essential oils and their components have been tested against insect pests (Leptinotarsa decemlineata, Spodoptera littoralis and Myzus persicae), root‐knot nematodes (Meloydogine javanica) and plants (Lactuca sativa, Lolium perenne, Solanum lycopersicum). The structure–activity relationships of these compounds have been studied including semi‐synthetic endocyclic trans‐carvone epoxide, exocyclic carvone epoxide, a new exocyclic piperitenone epoxide and trans‐pulegone epoxide. Leptinotarsa decemlineata feeding was affected by piperitenone and piperitone epoxide. Spodoptera littoralis was affected by piperitone epoxide and pulegone. The strongest nematicidal agent was piperitenone epoxide, followed by piperitone epoxide, piperitenone and carvone. Germination of S. lycopersicum and L. perenne was significantly affected by piperitenone epoxide. This compound and carvone epoxide inhibited L. perenne root and leaf growth. Piperitenone epoxide also inhibited the root growth of S. lycopersicum. The presence of a C(1) epoxide resulted in strong antifeedant, nematicidal and phytotoxic compounds regardless of the C(4) substituent. New natural crop protectants could be developed through appropriate structural modifications in the p‐menthane skeleton.
Mosaic partial pericentromeric trisomy 8 and maternal uniparental disomy in a male patient with autism spectrum disorder
Authors: Ahram Dina F. , Stambouli Danae , Syrogianni Aleksandra , Al‐Sarraj Yasser , Gerou Spyridon , El‐Shanti Hatem , Kambouris Marios 
Published: October 2016

Key Clinical MessageVarious chromosomal anomalies including small supernumerary marker chromosome (sSMC) and Uniparental disomy (UPD) have been described in association with intellectual disability and autism spectrum disorder. Based on our reported findings, we recommend that patients with sSMC(8) be evaluated for autism spectrum disorder (ASD) for early institution of therapy. In the presence of an identifiable sSMC, exploration of UPD is also recommended to further investigate the role of chromosome 8 UPD in ASD.
Access to Isoquinolin‐1(2 H)‐ones and Pyridones by Cobalt‐Catalyzed Oxidative Annulation of Amides with Allenes
Authors: Boobalan Ramadoss , Kuppusamy Ramajayam , Santhoshkumar Rajagopal , Gandeepan Parthasarathy , Cheng Chien‐Hong 
Published: October 2016

AbstractA cobalt‐catalyzed oxidative annulation of amides with allenes to provide isoquinolin‐1(2 H)‐ones and pyridones was explored. The new catalytic reaction proceeded through aminoquinoline‐directed C−H activation followed by unusual regioselective insertion, annulation, and isomerization. A variety of functionalized amides and allenes were converted into the corresponding products under mild reaction conditions.
Promotional Effects of Nanodiamond‐Derived Onion‐Like Carbons on the Electrocatalytic Properties of Pd‐MnO2 for the Oxidation of Glycerol in Alkaline Medium
Authors: Ejikeme Paul M. , Makgopa Katlego , Raju Kumar , Ozoemena Kenneth I. 
Published: October 2016

AbstractThe potential of onion‐like carbon (OLC) as an efficient alternative carbon support for palladium‐decorated manganese dioxide (Pd‐MnO2) catalyst for the electro‐oxidation of glycerol in alkaline medium is reported. Pd‐MnO2/OLC and Pd‐MnO2/C (where C denotes activated carbon or Vulcan carbon XC‐72) catalysts and their corresponding reference monometallic catalysts (Pd/OLC and Pd/C) are synthesized by a microwave‐assisted solvothermal procedure. Electrochemical measurements clearly prove that OLC, contrary to the state‐of‐the‐art Vulcan carbon XC‐72, is able to promote the electrocatalytic performance of Pd and Pd‐MnO2 towards the oxidation of glycerol in alkaline medium (in terms of decreased onset potential, large current density, and fast electron transport). Incredibly, the current density of the OLC‐based system is more than 150 % greater than their corresponding activated carbon‐based counterparts. These highly insightful results of Pd‐based catalyst are correlated with the synergistic effects of the ternary nanohybrid materials promoted by the unique intrinsic physico‐chemical properties of OLC.