bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Detection of Soil Available Phosphorus using Capacitively Coupled Contactless Conductivity Detection
Authors: Gao Jun , Li Wei , Li Jiaoe , Wang Rujing 
Published: September 2024

Background:
In China, the traditional method for analyzing soil available phospho-rus is inadequate for large-scale soil assessment and nationwide soil formulation demands. To address this, we propose a rapid and reliable method for soil-available phosphorus detection. The setup includes an on-site rapid pre-treatment device, a non-contact conductivity detection device, and a capillary electrophoresis buffer solution system composed of glacial acetic acid and hydroxypropyl-β-cyclodextrin.

Methods:
The on-site rapid pre-treatment process includes fresh soil moisture content detec-tion (moisture rapid detector), weighing (handheld weighing meter), stirring (handheld rapid stirrer), and filtration (soil rapid filter) to obtain the liquid sample, and direct injection (capil-lary electrophoresis detector). The phosphate ion detection parameters include capillary size, separation voltage, injection parameters, and electric injection. We used Liaoning brown soil, Henan yellow tidal soil, Heilongjiang black soil, and Anhui tidal soil as standard samples. Additionally, we used mathematical modeling methods and machine learning algorithms to analyze and process research data.

Results and Conclusion:
Following calibration with standard samples, the experimental blind test samples demonstrated conformity with the national standard method, exhibiting a relative standard deviation of less than 3%. The proposed pre-treatment device and non-contact con-ductivity detector are powered by lithium-ion batteries, rendering them ideal for extended field operations. The non-contact conductivity detector obviates the need for direct contact with test samples, mitigating environmental pollution. Furthermore, the neural network model exhibited the highest level of goodness of fit in chemical data analysis.
Novel N-Substituted Isatin-Oxoindolin-1H-Benzo[D] Imidazole Fumarate as a New Class of JNK3 Inhibitor: Design, Synthesis, Molecular Modeling and its Biological Activity
Authors: Al-Mahadeen Mohammed M. , Jaber Areej M. , Al-Najjar Belal O. , Khanfar Monther A. , El-Abadelah Mustafa M. 
Published: September 2024

Background:
A direct synthesis of functionalized dimethyl fumarate derivatives of 2-(2-((E)-(2-oxoindolin-3-ylidene)methyl)-1H-benzo[d]imidazol-1-yl) is achieved via one-pot reac-tion involving 2-methyl-1H-benzo[d]imidazole and appropriate isatin in the presence of DMAD.

Methods:
Conversely, this one-pot reaction furnished, upon conduction at 60 o C, the 2-(2-((E)-(2-oxoindolin-3-ylidene)methyl)-1H-benzo[d]imidazol-1-yl) products. The biological activities were evaluated against JNK3 kinase. We chose to dock the compounds into the JNK3 binding site in order to comprehend the molecular underpinnings of the observed bioactivities.

Results:
The structures of the synthesized compound adduct were evidenced from NMR and MS spectral data and further confirmed by single-crystal X-ray diffraction. The biological activities revealing that the introduction of an alkyl group at the 1-position of the isatin moiety produced JNK3 inhibitors with IC50 values in the low micromolar range.

Conclusion:
This study synthesized a unique compound using a three-component method. Com-pound 4d showed high antitumor activity (IC50 = 6.5 μM) against JNK3 inhibitors, while com-pounds 4c, 4d, and 4f exhibited high selectivity. The research highlights the effectiveness of the one-pot reaction in creating medically useful hybrid compounds, marking a significant advance in medicinal chemistry.
Ratiometric Fluorescent Probes for Copper Ion Detection and Cuproptosis Studies
Authors: Huang Yongbao , Wang Zhengjia , Feng Fengfeng , Wang Yan , Zhu Ruofei , Zhang Xiaolei , Zhang Sai , Qu Minghai , Yang Fan 
Published: September 2024

Abstract:
This study reviews the latest progress of ratiometric fluorescent probes of copper ions
from 2022 till now. As a key trace element in biological systems, copper ions play an important role
in a variety of biological processes. However, the abnormal change in copper ion concentration is
closely related to a variety of diseases, so the development of highly sensitive and highly selective
copper ion detection methods is of great significance for scientific research and clinical diagnosis. In
this paper, we first introduced the classification of copper ion fluorescence probes, including molecular
sensors based on five-membered azocycles, six-membered azocycles, imide groups (R2C=NR'),
oxygen and nitrogen functional groups (such as ethers, aldehydes, ketones, esters, carboxylic acids
and hydroxyl groups) and group ⅥA elements. Subsequently, the application of nanosensors in the
detection of copper ions is further discussed, especially the nanosensors in which copper is used as a
reactant, catalyst or alternative reaction. Finally, the current research status of copper ion fluorescence
probes is summarized, and the future development direction is prospected in order to provide
reference and inspiration for the design of new high-efficiency copper ion detection tools.
Comparison of the Efficacy of Povidone-Iodine with Mupirocin in Decolo-nizing Staphylococcus aureus from the Nasal Cavity of Healthcare Work-ers: A Single-Blinded Randomized Controlled Trial
Authors: Abolghasemi Sara , Ghazi Mona , Ziaie Shadi , Mahboubi Arash , Gachkar Latif , Keyvanfar Amirreza , Naeimipoor Mohammad 
Published: September 2024

Background:
Nasal colonization of Staphylococcus aureus increases the risk of nosocom-ial infections. Therefore, medications that can decolonize this pathogen can help prevent such infec-tions.

Objective:
Our study aimed to compare the efficacy of povidone-iodine solution with intranasal mupi-rocin ointment in decolonizing S. aureus from the nasal cavity of healthcare workers.

Methods:
This single-blinded randomized controlled trial was conducted on healthcare workers car-rying S. aureus nasally. After confirming nasal colonization through culture tests, participants were assigned to intervention groups A and B with an allocation ratio of 1:1. Group A received intranasal mupirocin ointment twice daily for five days, while group B received intranasal povidone-iodine so-lution twice daily for five days. After the decolonization period, samples were taken to compare the efficacy of both interventions in decolonizing S. aureus.

Results:
In this study, 54 healthcare workers with a mean age of 39.37±7.80 years were included, 42.6% and 57.4% of whom were male and female, respectively. They were randomly assigned to each of the intervention groups. After the intervention, individuals who received povidone-iodine had significantly more positive cultures than those who received mupirocin (37.0% vs. 11.1%, P = 0.026). Additionally, factors such as age, gender, wards, and employment duration may affect the efficacy of mupirocin and povidone-iodine in decolonizing S. aureus from the nasal cavity.

Conclusion:
The study findings revealed that both mupirocin and povidone-iodine were effective in decolonizing S. aureus from nasal carriers. However, mupirocin was more effective compared with povidone-iodine.
Effectiveness of Acupuncture for Infertility in Patients with Polycystic Ovary Syndrome: A Systematic Review and Network Meta-Analysis
Authors: Wu Yumi , Xiao QiWei , Wang ShouDong , Xu HuanFang , Fang YiGong 
Published: September 2024

Objective:
This study employs a network meta-analysis method to investigate the
clinical effectiveness of acupuncture in patients with polycystic ovary syndrome (PCOS) experiencing
infertility.

Methods:
Prospective randomized controlled trials (RCTs) of clomiphene citrate (CC) and letrozole
(LE) combined with acupuncture in PCOS infertility patients were identified through
computerized searches in databases including PubMed, Web of Science, Embase, Cochrane Library,
China National Knowledge Infrastructure (CNKI), Wanfang Data, and Chongqing VIP
Database. The search period was set from inception until August 1, 2023, with no language restrictions.
Two researchers screened articles, extracted data, and independently assessed the risk
of bias in eligible trials. Data were analyzed and visualized using the R software gemtc package.
With patients with medication treatment only set as controls, a meta-analysis was performed to
investigate the difference in the pregnancy outcomes of the PCOS patients following medication
amalgamated with different acupuncture treatments, namely, manual acupuncture (MA), electroacupuncture
(EA), and warm acupuncture (WA).

Results:
The serum concentrations of follicle-stimulating hormone (FSH) did not exhibit significant
changes following acupuncture treatments. Notably, acupuncture-based medication treatment
significantly reduced serum levels of luteinizing hormone (LH) and elevated the testosterone
(T) concentrations of patients when compared to medication treatment alone. Patients
also showed significantly escalated serum estradiol (E2) levels after receiving CC integrated
with acupuncture than those given monotherapy of CC. The combined regimen of medication
and acupuncture appeared to improve the pregnancy outcomes compared to the monotherapy of
medication, as evidenced by the significantly increased success rate of pregnancy. Furthermore,
the treatment combination of CC plus WA and LE plus MA yielded the highest probability of
achieving the best pregnancy outcomes.

Conclusion:
For PCOS infertility patients, acupuncture, as a complementary treatment to CC
and LE, holds advantages in improving reproductive hormone levels and enhancing pregnancy
success rates. The highest probability of achieving the best pregnancy outcomes is associated
with the treatment combination of CC with WA and LE with MA.
Design and Performance Evaluation of a Novel Vascular Interventional Surgery Robot
Authors: Mao Zhijie , Zhu Huba , Wei Juean , He Zhuowei , Li Zonglun , Yang Jingjing 
Published: September 2024

Introduction:
Minimally invasive interventional surgical robots are used as delivery
tools to assist healthcare professionals with medical devices such as micro guidewires and microcatheters
during surgical treatment of cardiovascular and cerebrovascular obstruction, thus reducing
surgical fatigue and radiation for healthcare professionals.

Method:
In this paper, a new vascular interventional surgical robot with multiple degrees of freedom
is designed, its mechanism principle and movement mode is discussed in detail, and a prototype
prototype is fabricated to make it simulate and reproduce the doctor's hand movements.

Results:
Through Abaqus simulation and platform experiments, the performance of the surgical
robot is evaluated and analyzed from the perspectives of micro guidewire delivery displacement
accuracy and radial clamping force for its high accuracy, high reliability, and safety.

Conclusion:
The results demonstrate that its surgical robot meets the requirements of providing
vessel wall overload protection while the microcatheter delivery positioning accuracy error is less
than 1 mm.
Uji Kecernaan Nutrien Secara In Vitro dan Analisis Komponen Serat Kasar Limbah Bunga Sedap Malam (Polianthes tuberosa L.) Terfermentasi Aspergillus niger
Authors: Badriyah Nufus Imamil , Ali Usman , Sumartono Sumartono 
Published: September 2024

Tujuan penelitian adalah menganalisis pengaruh dan mempelajari dosis paling efisien dari penggunaan Aspergillus niger pada fermentasi limbah bunga sedap malam (Polianthes tuberosa L.) dengan parameter Kecernaan Bahan Kering (KcBK), Kecernaan Bahan Organik (KcBO), Kecernaan Protein Kasar (KcPK) secara in vitro, kandungan Neutral Detergent Fiber (NDF), Acid Detergent Fiber (ADF), dan Hemiselulosa. Metode penelitian ini adalah eksperimen dengan menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 5 perlakuan dan 4 ulangan. Setiap perlakuan terdiri dari 200 gram limbah bunga sedap malam (BK 94,83%), 2% molases, dan 274 ml air. Penggunaan dosis Aspergillus niger yang berbeda terdiri dari P0 : Kontrol (Tanpa Fermentasi), P1 : 1 x 107 CFU/g BK Bahan, P2 : 3 x 107 CFU/g BK Bahan, P3 = 6 x 107 CFU/g BK Bahan, dan P4 : 9 x 107 CFU/g BK Bahan. Hasil penelitian menunjukkan adanya pengaruh sangat nyata (P<0,01) terhadap kecernaan nutrien dan komponen serat kasar. Dosis 9 x 107 CFU/g BK Bahan terbukti memberikan hasil terbaik diantara dosis yang lainnya ditinjau dari beberapa parameter yang telah diukur yaitu 46,62±1,1% KcBK, 46,26±0,16% KcBO, 52,86±0,07% KcPK, 28,96±0,28% NDF, 22,64±0,43% ADF dan 6,32±0,35% Hemiselulosa. Kesimpulan penelitian ini adalah penggunaan Aspergillus niger sebagai inokulan dalam proses fermentasi limbah bunga sedap malam meningkatkan KcBK, KcBO, dan KcPK serta diikuti dengan penurunan kandungan NDF, ADF dan Hemiselulosa.
Primary Pre-Extensively Drug-Resistant (Pre-XDR) Tuberculosis with Meningoencephalitis in Nineteen Years Old Young Woman : A Case Report
Authors: Sugiri Yani Jane Rosihaningsih , Tantular Rezki , Falyani Silvy Amalia , Maulana Uray Riki Arif 
Published: September 2024

Introduction. Mycobacterium tuberculosis (MTB) is continually evolving in order to resist treatment. This has resulted in drug-resistant tuberculosis, which has a greater rate of therapy failure and mortality, as well as the necessity for other ways of disease transmission prevention. Pre-extensively drug-resistant tuberculosis (Pre-XDR TB) is caused by MTB strains that are resistant to isoniazid, rifampicin, and any fluoroquinolone medicines.
Case Report. A 19-year-old HIV-negative immunocompetent female presented to our emergency department with dyspnea and severe headache. She also complained of a cough, a low-grade temperature, and weight loss. She has no relevant medical history and has never been exposed to tuberculosis. A chest X-ray revealed infiltrates with cavities and fibrosis in both lungs, while a brain CT suggested meningoencephalitis. We performed a sputum drug sensitivity test and discovered that this patient was resistant to rifampin, isoniazid, levofloxacin, and moxifloxacin. She was later diagnosed with Pre-XDR TB and was given a tailored lengthier regimen that included Bedaquiline, Cycloserin, Linezolide, Clofazimine, and Etambutol. Her symptoms improved significantly as a result of this program.
Discussion. Primary pre-XDR TB in an immunocompetent patient is uncommon, and our case is even more unusual due to meningoencephalitis involvement. The treatment of pre-XDR TB requires a personalized regimen that is tailored to the patient's clinical status and comorbidities. The possibility of transmission via a positive contact was raised in this patient, prompting us to conduct a more thorough contact inquiry to prevent future spread.
Conclusion. In our region, there is a risk of'silent' drug resistant tuberculosis. Early detection and treatment of such patients are critical to preventing uncontrollable pan-resistant TB. Successful management with cautious contact investigation will minimize the mortality rate and spread rate of drug-resistant TB.

Keywords. Drug-Resistant Lung Tuberculosis, Drug-Resistant Meningoencephalitis Tuberculosis
Penghambatan Penurunan Mutu Cookies Substitusi Tepung Oat Dengan Jenis Kemasan Plastik Berbeda Terhadap Karakteristik Fisikokimia Dan Organoleptik Selama Penyimpanan
Authors: Dharlyansyah Risky , Sukardi Sukardi , Utomo Joko Susilo 
Published: September 2024

Soft cookies merupakan salah satu jenis cookies dengan tekstur renyah diluar dan lembut (chewy) di dalam karena bagian tengah adonan tersebut masih lunak. Produk makanan yang cenderung basah hingga kering mudah mengalami perubahan mutu jika disimpan dalam waktu yang lama. Penelitian ini bertujuan untuk mengetahui pengaruh jenis kemasan dan lama penyimpanan terhadap karakteristik oat cookies, serta untuk mengetahui pendugaan umur simpan oat cookies. Penelitian ini menggunakan Rancangan Tersarang (Nested) yang terdiri dari dua faktor. Faktor dari rancangan ini lama penyimpanan dan jenis kemasan plastik berbeda. Parameter yang diamati meliputi analisa proksimat, kadar serat kasar, aktivitas air (Aw), kekerasan, dan organoleptik meliput aroma, tekstur, rasa, dan keberterimaan. Berdasarkan hasil penelitian yang telah dilakukan menunjukkan bahwa jenis kemasan berpengaruh nyata terhadap nilai kadar air, Aw, dan kekerasan pada oat cookies. Kadar serat kasar juga menunjukkan dipengaruhi oleh dua faktor tersebut yaitu jenis kemasan berbeda dan lama penyimpanan. Kadar abu, protein, lemak, dan karbohidrat tidak menunjukkan pengaruh signifikan dari jenis kemasan dan lama penyimpanan, tetapi terdapat aktivitas kimia dan biologis yang terjadi pada oat cookies. Uji organoleptik oat cookies menghasilkan aroma yang sudah hilang aroma mentega, rasa yang manis dan sedikit getir, tekstur yang agak keras, dan keberterimaan yang netral dengan perkiraan dapat diterima minggu ke-3. Pendugaan umur simpan menggunakan metode ESS dengan titik kritis kadar air dihasilkan kemasan PP 13 hari, PS 19 hari, dan OPP 18 hari serta diperoleh kemasan OPP merupakan jenis kemasan yang dapat mempertahankan mutu oat cookies lebih baik.
PENGARUH KONSENTRASI ASAM KLORIDA (HCl) DAN WAKTU EKSTRAKSI PADA KARAKTERISASI PEKTIN KULIT JERUK BALI (Citrus maxima)
Authors: Zahro Nur Alfiatus , Warkoyo Warkoyo , Wahyudi Vritta Amroini 
Published: September 2024

Pectin or pectate compounds are complex polysaccharides with large molecular weights found in the middle lamella or intercellular spaces in higher plant tissues. The main function of pectin is as a thickener and gelling agent. So far, pectin production in Indonesia has not been widely known and developed. Pectin can be obtained from fruit peels, one of which is grapefruit peel. Grapefruit has a fairly high pectin content, around 30%. The purpose of this study was to find out how much pectin content is in grapefruit peels by determining the concentration of hydrochloric acid and the right extraction time to get the best yield and quality of pectin.
This study used a randomized block design (RBD) method with two factors, namely the concentration of hydrochloric acid 0.2 N; 0.25 N and 0.3 N and extraction times of 60, 90 and 120 minutes with three repetitions. The observations made were yield pectin, water content, ash content, equivalent weight, methoxyl content, galacturonic acid and degree of esterification. The data obtained based on the research results were analyzed statistically with variance (α = 0.05) and continued with the Duncan Multiple Range Test (DMRT).
The results showed that the concentration of hydrochloric acid 0.3 N and extraction time of 120 minutes produced the best pectin with yield 13.57%, moisture content 8.27%, ash content 7.53%, methoxyl content 6.79%, galacturonic content 261 .65%, the degree of esterification is 14.82% and it can be concluded that the test results for the characteristics of the pectin produced meet the established standards of the International Pectin Producers Association (IPPA).
Importancia de los procesos de clasificación, catalogación y sistematización de registros bibliográficos en las bibliotecas públicas de Pasto e Ipiales, Colombia.
Authors: Arteaga Figueroa Angela María , Paz Meneses Alexy Amanda 
Published: September 2024

En el marco del desarrollo del trabajo de grado de la Maestría en Estudios Latinoamericanos de la Universidad de Nariño titulado: “Sistemas de Información, Clasificación y Catalogación Bibliotecas Públicas Municipales de Pasto e Ipiales, Colombia” se evidencia la necesidad de revisar los procesos de carácter técnico para validar la disponibilidad de material bibliográfico a partir de registros bibliográficos sistematizados. El presente artículo, permitirá reconocer la importancia de los procesos técnicos llevados a cabo al interior de las bibliotecas públicas de las ciudades de Pasto e Ipiales en el Departamento de Nariño Colombia, para adelantar operaciones de búsqueda y recuperación de información.
La resiliencia emprendedora en el periodo pos-cuarentena COVID-19
Authors: Rebolledo Castillo Danny Miguel 
Published: September 2024

Esta investigación realiza un análisis de la resiliencia de los emprendedores del sector servicios, ante la crisis económica generada por la cuarentena y el aislamiento por la pandemia del virus del COVID-19. Para ello se usa un método documental y descriptivo;, consistente en la revisión de fuentes secundarias (50 documentos; artículos, capítulos de libros, e informes oficiales en países de América, Europa, Asia y África), identificando las estrategias, cambios y medidas implementadas por los emprendedores del sector servicios. Sobresalen más de 12 estrategias comunes: cambio de modalidad de servicios, de medios de comercialización, de actividad económica, la reducción de personal y el cierre de empresas; por lo cual, se necesita el análisis del impacto en el desempleo en el sector.
OPTIMALISASI LITERASI DIGITAL DALAM MENINGKATKAN KESADARAN KEAMANAN SIBER UNTUK SISWA DI SMK KESEHATAN CIPTA BHAKTI HUSADA YOGYAKARTA
Authors: Siregar Ilham Ramadan Pandu Setia Negara , Hidayat Rahmat Rian , Candraningtyas Anindya Dewi , Hissan Iin Khaeratun , Oktaviani Ria 
Published: September 2024

Digital literacy is not only limited to the ability to use digital devices and applications, but also involves a deep understanding of cyber security awareness. In this digital era, threats to cyber security are increasingly complex and can affect the continuity of every aspect of life, including education and health. Therefore, increasing awareness of the importance of cyber security, especially among students at the Cipta Bhakti Husada Yogyakarta Health Vocational School is crucial. In this research, the author used a qualitative research method with a descriptive model. Through this activity, it is hoped that it can provide students with a better understanding of potential risks and precautions in cyberspace. In addition, we want to improve students' skills in using technology wisely, ethically, and safely. We also need to be committed to continuing to develop digital literacy and cyber security awareness among students so that students can grow into an intelligent and creative generation in facing a digital era full of challenges. In this way, they can become agents of change who are able to face the challenges of the digital world with a positive and responsible attitude. Keywords: Digital Literacy; Cyber Security Cipta Bhakti Husada Yogyakarta Health Vocational School Students
The Effect of the Current Expected Credit Loss Approach on Banks’ Lending during Stress Periods: Evidence from the COVID-19 Recession
Authors: Chen Jing , Dou Yiwei , Ryan Stephen G. , Zou Youli 
Published: September 2024

ABSTRACT
In the wake of the financial crisis, policymakers expressed the concern that the incurred loss model delays loan loss recognition to economic stress periods and thereby exacerbates banks’ lending contraction during these periods. Addressing this concern, the FASB issued Accounting Standards Update 2016-13, which requires large public banks to accrue for loan losses using the current expected credit loss (CECL) approach starting in January 2020. We hypothesize and find that banks that adopted CECL prior to the COVID-19 pandemic increased loan loss provisions and reduced loan growth during the accompanying recession more than other banks. The lending contraction is stronger for adopting banks with low regulatory capital and low loan impairment and is primarily driven by commercial loans. Lastly, we find that counties in which CECL-adopting banks have higher market share experience larger increases in unemployment rates during the recession and slower subsequent recoveries.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: E32; G21; G28; M41; M48.