bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Hybrid En3DVar Data Assimilation System and Comparisons with 3DVar and EnKF for Radar Data Assimilation with Observing System Simulation Experiments
Authors: Kong Rong , Xue Ming , Liu Chengsi 
Published: December 2017

Abstract
A hybrid ensemble–3DVar (En3DVar) system is developed and compared with 3DVar, EnKF, “deterministic forecast” EnKF (DfEnKF), and pure En3DVar for assimilating radar data through perfect-model observing system simulation experiments (OSSEs). DfEnKF uses a deterministic forecast as the background and is therefore parallel to pure En3DVar. Different results are found between DfEnKF and pure En3DVar: 1) the serial versus global nature and 2) the variational minimization versus direct filter updating nature of the two algorithms are identified as the main causes for the differences. For 3DVar (EnKF/DfEnKF and En3DVar), optimal decorrelation scales (localization radii) for static (ensemble) background error covariances are obtained and used in hybrid En3DVar. The sensitivity of hybrid En3DVar to covariance weights and ensemble size is examined. On average, when ensemble size is 20 or larger, a 5%–10% static covariance gives the best results, while for smaller ensembles, more static covariance is beneficial. Using an ensemble size of 40, EnKF and DfEnKF perform similarly, and both are better than pure and hybrid En3DVar overall. Using 5% static error covariance, hybrid En3DVar outperforms pure En3DVar for most state variables but underperforms for hydrometeor variables, and the improvement (degradation) is most notable for water vapor mixing ratio qυ (snow mixing ratio qs). Overall, EnKF/DfEnKF performs the best, 3DVar performs the worst, and static covariance only helps slightly via hybrid En3DVar.
Acculturative stress, poor mental health and condom-use intention among international students in China
Authors: Yang Ningxi , Xu Yayun , Chen Xinguang , Yu Bin , Yan Hong , Li Shiyue 
Published: December 2017

Objectives: Engaging in sexual risk behaviour can be a maladaptive strategy for international students to deal with stress. This study examined the role of poor mental health in mediating the relationship between acculturative stress and condom-use intention among international students in Beijing, China. Methods: The study used a cross-sectional design, and the participants were enrolled through convenience sampling. The mediation effects of poor mental health were assessed using structural equation modelling. Setting: Participants included 299 international students (143 men, mean age = 21.87 ± 3.23) who were studying in Beijing, China. Results: Correlation analysis revealed that acculturative stress was negatively associated with condom-use intentions ( r = –.250, p < .01) and positively associated with poor mental health ( r = .458, p < .01). Condom-use intentions were negatively related to poor mental health ( r = –.258, p < .01). Structural equation model analysis showed that overall poor mental health, as well as anxiety, phobic anxiety and psychoticism, mediated the relationship between acculturative stress and condom-use intentions among men. The same mediation effects for women were not statistically significant. Conclusions: Poor mental health can mediate the relationship between acculturative stress and condom-use intention among male international students in Beijing, China. Findings suggest that programmes and interventions to target acculturative stress and psychological problems may be useful in preventing international students from engaging in sexual risk behaviour.
Drip infusion cholangiography with CT in cats
Authors: Tanaka Toshiyuki , Akiyoshi Hideo , Mie Keiichiro , Shimazaki Hitoshi , Ohashi Fumihito 
Published: December 2017

Objectives Ultrasonography can detect extrahepatic biliary obstructions. However, visualisation of part of the bile duct using ultrasonography can be technically difficult if there is overlying bowel gas. This study investigated the safety and value of drip infusion cholangiography with computed tomography (DIC-CT) in the visualisation of the bile duct in healthy cats and extrahepatic biliary obstruction in cats with cholelithiasis. Methods DIC-CT was performed in three healthy cats and two cats with cholelithiasis. Meglumine iotroxate was administered by intravenous drip infusion over 30 mins. The attenuation value was measured perpendicular to the lumen by a region of interest covering about 50% of the area of the lumen. Results The bile ducts were visualised successfully with DIC-CT in all healthy cats without any significant adverse events. The attenuation value of the contrast medium was 271 ± 37 HU. In the two cats with cholelithiasis, the presence or absence of extrahepatic biliary obstruction was determined using DIC-CT without any significant adverse events. The attenuation value of cholelithiasis in the cat with an extrahepatic biliary obstruction was 933 ± 119 HU. In the cat with no extrahepatic biliary obstruction, the attenuation value of the contrast medium was 249 ± 53 HU and the attenuation value of cholelithiasis was 167 ± 28 HU. Conclusions and relevance DIC-CT visualises bile ducts and detects obstructive biliary disease without significant adverse events. Therefore, it appears to be a safe procedure for visualisation of the bile duct in cats.
A Comparison of Removal Rates of Headless Screws Versus Headed Screws in Calcaneal Osteotomy
Authors: Kunzler Daniel , Shazadeh Safavi Pejma , Jupiter Daniel , Panchbhavi Vinod K. 
Published: December 2017

Background: Calcaneal osteotomy has been used to successfully treat both valgus and varus hindfoot deformities. Pain associated with implanted hardware may lead to further surgical intervention for hardware removal. Headless screws have been used to reduce postoperative hardware-associated pain and accompanying hardware removal, but data proving their effectiveness in this regard is lacking. The purpose of this study is to compare the rates of removal of headed and headless screws utilized in calcaneal osteotomy. Methods: We conducted a retrospective chart review of 74 patients who underwent calcaneal osteotomy between January 2010 and December 2014. The cohort was divided into 2 groups by fixation method: a headed screw and a headless screw group. Bivariate associations between infection or hardware removal, and screw type, screw head width, gender, smoking status, alcohol, hypertension, diabetes, hyperlipidemia, age, and body mass index were assessed using t-tests and Fisher’s exact/χ2 tests for continuous and discrete variables, respectively. Results: Headed screws were removed more frequently than headless screws (P < .0001): 15 of 30 (50%) feet that received headed screws and 4 of 44 (9%) of feet that received headless screws underwent subsequent revision for screw removal. In all cases, screws were removed because of pain. The calcaneal union rate was 100% in both cohorts. Conclusion: The rate of screw removal in calcaneal osteotomies is significantly lower in patients who receive headless screws than in those receiving headed screws. Levels of Evidence: Level IV
A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia
Authors: Stein Eytan M. , Walter Roland B. , Erba Harry P. , Fathi Amir T. , Advani Anjali S. , Lancet Jeffrey E. , Ravandi Farhad , Kovacsovics Tibor , DeAngelo Daniel J. , Bixby Dale , Faderl Stefan , Jillella Anand P. , Ho Phoenix A. , O’Meara Megan M. , Zhao Baiteng , Biddle-Snead Charles , Stein Anthony S. 
Published: December 2017

Key Points
Vadastuximab talirine, a novel antibody-drug conjugate, consists of an anti-CD33 monoclonal antibody conjugated to pyrrolobenzodiazepine dimers. In a phase 1 trial, vadastuximab talirine demonstrated single-agent activity and minimal nonhematologic toxicity in patients with AML.
Expression of TP53 is associated with the outcome of MCL independent of MIPI and Ki-67 in trials of the European MCL Network
Authors: Aukema Sietse M. , Hoster Eva , Rosenwald Andreas , Canoni Danielle , Delfau-Larue Marie-Hélène , Rymkiewicz Grzegorz , Thorns Christoph , Hartmann Sylvia , Kluin-Nelemans Hanneke , Hermine Olivier , Dreyling Martin , Klapper Wolfram 
Published: December 2017

Key Points
TP53 expression (>50% positive cells) has shorter TTF and poor OS independent of both MIPI score and Ki67 index.
European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency
Authors: Miravitlles Marc , Dirksen Asger , Ferrarotti Ilaria , Koblizek Vladimir , Lange Peter , Mahadeva Ravi , McElvaney Noel G. , Parr David , Piitulainen Eeva , Roche Nicolas , Stolk Jan , Thabut Gabriel , Turner Alice , Vogelmeier Claus , Stockley Robert A. 
Published: December 2017

α1-antitrypsin deficiency (AATD) is the most common hereditary disorder in adults. It is associated with an increased risk of developing pulmonary emphysema and liver disease. The pulmonary emphysema in AATD is strongly linked to smoking, but even a proportion of never-smokers develop progressive lung disease. A large proportion of individuals affected remain undiagnosed and therefore without access to appropriate care and treatment.The most recent international statement on AATD was published by the American Thoracic Society and the European Respiratory Society in 2003. Since then there has been a continuous development of novel, more accurate and less expensive genetic diagnostic methods. Furthermore, new outcome parameters have been developed and validated for use in clinical trials and a new series of observational and randomised clinical trials have provided more evidence concerning the efficacy and safety of augmentation therapy, the only specific treatment available for the pulmonary disease associated with AATD.As AATD is a rare disease, it is crucial to organise national and international registries and collect information prospectively about the natural history of the disease. Management of AATD patients must be supervised by national or regional expert centres and inequalities in access to therapies across Europe should be addressed.
The physiological effects of slow breathing in the healthy human
Authors: Russo Marc A. , Santarelli Danielle M. , O’Rourke Dean 
Published: December 2017

Slow breathing practices have been adopted in the modern world across the globe due to their claimed health benefits. This has piqued the interest of researchers and clinicians who have initiated investigations into the physiological (and psychological) effects of slow breathing techniques and attempted to uncover the underlying mechanisms. The aim of this article is to provide a comprehensive overview of normal respiratory physiology and the documented physiological effects of slow breathing techniques according to research in healthy humans. The review focuses on the physiological implications to the respiratory, cardiovascular, cardiorespiratory and autonomic nervous systems, with particular focus on diaphragm activity, ventilation efficiency, haemodynamics, heart rate variability, cardiorespiratory coupling, respiratory sinus arrhythmia and sympathovagal balance. The review ends with a brief discussion of the potential clinical implications of slow breathing techniques. This is a topic that warrants further research, understanding and discussion.Key pointsSlow breathing practices have gained popularity in the western world due to their claimed health benefits, yet remain relatively untouched by the medical community.Investigations into the physiological effects of slow breathing have uncovered significant effects on the respiratory, cardiovascular, cardiorespiratory and autonomic nervous systems.Key findings include effects on respiratory muscle activity, ventilation efficiency, chemoreflex and baroreflex sensitivity, heart rate variability, blood flow dynamics, respiratory sinus arrhythmia, cardiorespiratory coupling, and sympathovagal balance.There appears to be potential for use of controlled slow breathing techniques as a means of optimising physiological parameters that appear to be associated with health and longevity, and that may extend to disease states; however, there is a dire need for further research into the area.Educational aimsTo provide a comprehensive overview of normal human respiratory physiology and the documented effects of slow breathing in healthy humans.To review and discuss the evidence and hypotheses regarding the mechanisms underlying slow breathing physiological effects in humans.To provide a definition of slow breathing and what may constitute “autonomically optimised respiration”.To open discussion on the potential clinical implications of slow breathing techniques and the need for further research.
The potential of palliative care for patients with respiratory diseases
Authors: Narsavage Georgia L. , Chen Yea-Jyh , Korn Bettina , Elk Ronit 
Published: December 2017

Based on the demonstrated effectiveness of palliative care in the alleviation of symptoms and enhancement of life quality, it is important to incorporate palliative care early in the respiratory disease trajectory. Quality palliative care addresses eight domains that are all patient and family centred. Palliative care interventions in respiratory conditions include management of symptoms such as dyspnoea, cough, haemoptysis, sputum production, fatigue and respiratory secretion management, especially as the end-of-life nears. A practical checklist of activities based on the domains of palliative care can assist clinicians to integrate palliative care into their practice. Clinical management of patients receiving palliative care requires consideration of human factors and related organisational characteristics that involve cultural, educational and motivational aspects of the patient/family and clinicians.Educational aimsTo explain the basic domains of palliative care applicable to chronic respiratory diseases.To review palliative care interventions for patients with chronic respiratory diseases.To outline a checklist for clinicians to use in practice, based on the domains of palliative care.To propose recommendations for clinical management of patients receiving palliative care for chronic respiratory diseases.
Systematic review into factors associated with the recruitment crisis in psychiatry in the UK: students', trainees' and consultants' views
Authors: Choudry Abid , Farooq Saeed 
Published: December 2017

Aims and methodTo review the literature to examine the factors that may be affecting recruitment into psychiatry in the UK. We systematically searched four databases to identify studies from 1974 to 2016 and identified 27 papers that met the specified inclusion criteria.ResultsMost papers (n= 24) were based on questionnaire surveys. The population in all studies comprised of 1879 psychiatrists, 6733 students and 220746 trainees. About 4–7% of students opt for a career in psychiatry. Enrichment activities helped to attract students more towards psychiatry than just total time spent in the specialty. Job content in terms of the lack of scientific basis, poor prognosis and stigma towards psychiatry, work-related stress and problems with training jobs were common barriers highlighted among students and trainees, affecting recruitment. Job satisfaction and family-friendly status of psychiatry was rated highly by students, with lifestyle factors appearing to be important for trainees who tend to choose psychiatry.Clinical implicationsNegative attitudes and stigma towards psychiatry continue to persist. Teaching and training in psychiatry needs rethinking to improve student experience and recruitment into the specialty.
National survey of training of psychiatrists on advance directives to refuse treatment in bipolar disorder
Authors: Morriss Richard , Mudigonda Mohan , Bartlett Peter , Chopra Arun , Jones Steven 
Published: December 2017

Aims and methodTo determine features associated with better perceived quality of training for psychiatrists on advance decision-making in the Mental Capacity Act 2005 (MCA), and whether the quality or amount of training were associated with positive attitudes or use of advance decisions to refuse treatment (ADRTs) by psychiatrists in people with bipolar disorder. An anonymised national survey of 650 trainee and consultant psychiatrists in England and Wales was performed.ResultsGood or better quality of training was associated with use of case summaries, role-play, ADRTs, assessment of mental capacity and its fluctuation. Good or better quality and two or more sessions of MCA training were associated with more positive attitudes and reported use of ADRTs, although many psychiatrists would never discuss them clinically with people with bipolar disorder.Clinical implicationsConsistent delivery of better-quality training is required for all psychiatrists to increase use of ADRTs in people with bipolar disorder.
Measuring relational security in forensic mental health services
Authors: Chester Verity , Alexander Regi T. , Morgan Wendy 
Published: December 2017

Aims and methodRelational security is an important component of care and risk assessment in mental health services, but the utility of available measures remains under-researched. This study analysed the psychometric properties of two relational security tools, the See Think Act (STA) scale and the Relational Security Explorer (RSE).ResultsThe STA scale had good internal consistency and could highlight differences between occupational groups, whereas the RSE did not perform well as a psychometric measure.Clinical implicationsThe measures provide unique and complimentary perspectives on the quality of relational security within secure services, but have some limitations. Use of the RSE should be restricted to its intended purpose; to guide team discussions about relational security, and services should refrain from collecting and aggregating this data. Until further research validates their use, relational security measurement should be multidimensional and form part of a wider process of service quality assessment.
Randomized Clinical Trial of Preoperative High-Dose Methylprednisolone on Postoperative Pain at Rest After Laparoscopic Appendectomy
Authors: Kleif Jakob , Hauge Camilla I. , Vilandt Jesper , Gögenur Ismail 
Published: December 2017

BACKGROUND:
Methylprednisolone administered intravenously preoperatively has been shown to reduce pain, nausea, and fatigue after elective surgery. We aimed to show that 125 mg of methylprednisolone given intravenously 30 minutes before laparoscopic surgery for suspected appendicitis would reduce pain at rest during the first 3 postoperative days.

METHODS:
A multicenter, parallel-group, double-blind, placebo-controlled study was conducted including patients 18 years of age and older with an American Society of Anesthesiologist class of I–III undergoing laparoscopic surgery for suspected appendicitis. The primary outcome was pain at rest measured on the 11-point numerical rating scale 5 times during the first 3 days after surgery. The effect of 125 mg of methylprednisolone on postoperative pain at rest during the first 3 days was assessed using a mixed-effects model with time and intervention as main effects.

RESULTS:
From April 2016 to August 2016, 78 patients were included, and all were eligible for analysis of the primary outcome. The estimated effect of 125 mg of methylprednisolone on pain at rest during the first 3 days after surgery was a nonsignificant increase of 0.2 (95% confidence interval, −0.5 to 0.9; P = .571) on the 11-point numerical rating scale. There was no difference between the 2 groups regarding the need for opioid agonists during hospital stay on the first postoperative day (P = .381).

CONCLUSIONS:
A 125-mg dose of methylprednisolone given intravenously 30 minutes before laparoscopic surgery for appendicitis seemed no better than placebo at providing a clinical meaningful reduction in postoperative pain at rest.
High-content tripartite split-GFP cell-based assays to screen for modulators of small GTPase activation
Authors: Koraïchi Faten , Gence Rémi , Bouchenot Catherine , Grosjean Sarah , Lajoie-Mazenc Isabelle , Favre Gilles , Cabantous Stéphanie 
Published: December 2017

ABSTRACT
The human Ras superfamily of small GTPases controls essential cellular processes such as gene expression and cell proliferation. As their deregulation is widely associated with human cancer, small GTPases and their regulatory proteins have become increasingly attractive for the development of novel therapeutics. Classical methods to monitor GTPase activation include pulldown assays that limit the analysis of GTP-bound form of proteins from cell lysates. Alternatively, live-cell FRET biosensors may be used to study GTPase activation dynamics in response to stimuli, but these sensors often require further optimization for high-throughput applications. Here, we describe a cell-based approach that is suitable to monitor the modulation of small GTPase activity in a high-content analysis. The assay relies on a genetically encoded tripartite split-GFP (triSFP) system that we integrated in an optimized cellular model to monitor modulation of RhoA and RhoB GTPases. Our results indicate the robust response of the reporter, allowing the interrogation of inhibition and stimulation of Rho activity, and highlight potential applications of this method to discover novel modulators and regulators of small GTPases and related protein-binding domains.
Names of Assam tea: Their priority, typification and nomenclatural notes
Authors: Zhao Dongwei , Parnell John A.N. , Hodkinson Trevor R. 
Published: December 2017

AbstractVarious names have been used for Assam tea and they are typified here. The currently widely used name, Camellia sinensis var. assamica, is a combination based on Thea viridis var. assamica, not “T. assamica” because the latter was never validly published. Two earlier published names, C. theifera and T. cochinchinensis, and two later ones, C. tenuistipa and T. yersinii, may represent the same taxon and are treated as synonyms of T. viridis var. assamica because the latter has priority at the rank of variety and therefore is the correct name for Assam tea.
Prevalence of Dysphagia in People With Intellectual Disability: A Systematic Review
Authors: Robertson Janet , Chadwick Darren , Baines Susannah , Emerson Eric , Hatton Chris 
Published: December 2017

AbstractDysphagia (feeding and swallowing disorder) is associated with serious health complications and psychosocial sequelae. This review summarizes international research relating to the prevalence of dysphagia in people with intellectual disability. Studies published from 1990 to July 2016 were identified using Medline, Cinahl, PsycINFO, Web of Science, email requests, and cross-citations. Twenty studies were identified. Dysphagia in people with intellectual disability appears to be associated with more severe levels of intellectual disability, comorbid cerebral palsy, and motor impairments. However, further research with representative samples of people with intellectual disability using adequate methods of assessment are required in order to provide more precise prevalence estimates and clarify factors that may be associated with dysphagia in this population.