bluuebunny/crossref_metadata_2025_split huggingface dataset:
Four odorants for olfactory training are enough: a pilot study
Authors: Power Guerra Nicole , Kruschwitz Emely , Krautwurst Dietmar , Hummel Thomas 
Published: September 2024

AbstractBackground: Olfactory training (OT) is commonly used for the treatment of olfactory disorders. Nevertheless, there is an ongoing debate about the most effective OT regimen. We aimed to compare the effects of OT with 7 items (rose, lemon, eucalyptus, cloves, stewed apple, balm, mint) to 4-item-OT (rose, lemon, eucalyptus, cloves) over 3 months. Methods: Participants were 40 patients with olfactory dysfunction receiving 4-item-OT or 7-item-OT and 60 gender- and age-matched individuals with normal sense of smell receiving no OT, 4-item-OT, or 7-item-OT. Before and after the OT we assessed n-butanol odor thresholds, discrimination, and identification (TDI score), additionalthresholds for (R)-(-)-carvone, β-damascenone, salicyclic acid benzylester, the degree of phantosmia and parosmia, cognitive function, and ratings of olfactory function. Results: In both patient groups, the TDI score increased with the use of OT, regardless of the number of odors used (p < 0.001; 3.48 ± 4.21 and lower than control groups). The clinically significant increase of 5.5 points in TDI score correlated with change of ratings of parosmia (r 0.62; p < 0.01) and with ratings of olfactory dysfunction (r = 0.51; p < 0.05). Conclusion: Concluding, OT over a 3-months period with 4 or 7 odors appears to produce similar results, although the sample size has to be considered.
Perioperative and postoperative management of tympanostomy tube insertion: a survey of otorhinolaryngologists in Israel
Authors: Dudkiewicz Dean , Bismuth Efrat Miryam , Tsur Nir , Gilony Dror , Hod Roy 
Published: September 2024

Abstract

Background
Tympanostomy tube insertion is a standard surgical procedure in children to address middle ear infections and effusion-related hearing and speech development issues. Perioperative treatments like ear drops containing antibiotics, steroids, and tube irrigation with saline aim to prevent complications, yet no universal gold standard treatment exists. Despite guidelines, practice preferences among ENT specialists vary, motivating this study to investigate perioperative management practices in Israel.

Method
A survey was distributed among ENT surgeons, collecting data on their main workplace, sub-specialty, preoperative hearing test requirements, tube irrigation practices, tube selection criteria, and timing of tube removal. Distribution and association with main workplaces were examined.

Results
The survey achieved a response rate of 27.33%. Most participants routinely required preoperative hearing tests, with a preference for conducting them within three months prior to surgery (62.2%). Tube irrigation during the procedure was less common among surgeons in the public system (p = 0.007). In response to the COVID-19 pandemic, the majority of respondents maintained their established practices (96.3%), while a small proportion (3.7%) adapted by replacing two in-person meetings with one virtual session. Variations in tube removal timing based on the main workplace were noted, with private practitioners opting for earlier removal (p = 0.002) and were less permissive in water deprivation practices (p = 0.053).

Conclusion
This study provides insights into the practices and preferences of ENT surgeons in tympanostomy tube insertion procedures in Israel. Adherence to standardized practices was observed, with variations influenced by the primary workplace. Despite the COVID-19 pandemic, minimal changes were made to established practices. Further research and consensus are necessary to optimize patient outcomes and develop tailored guidelines in this field.
Automated algorithms for seizure forecast: a systematic review and meta-analysis
Authors: Carmo Ana Sofia , Abreu Mariana , Baptista Maria Fortuna , de Oliveira Carvalho Miguel , Peralta Ana Rita , Fred Ana , Bentes Carla , da Silva Hugo Plácido 
Published: September 2024

AbstractThis study aims to review the proposed methodologies and reported performances of automated algorithms for seizure forecast. A systematic review was conducted on studies reported up to May 10, 2024. Four databases and registers were searched, and studies were included when they proposed an original algorithm for automatic human epileptic seizure forecast that was patient specific, based on intraindividual cyclic distribution of events and/or surrogate measures of the preictal state and provided an evaluation of the performance. Two meta-analyses were performed, one evaluating area under the ROC curve (AUC) and another Brier Skill Score (BSS). Eighteen studies met the eligibility criteria, totaling 43 included algorithms. A total of 419 patients participated in the studies, and 19442 seizures were reported across studies. Of the analyzed algorithms, 23 were eligible for the meta-analysis with AUC and 12 with BSS. The overall mean AUC was 0.71, which was similar between the studies that relied solely on surrogate measures of the preictal state, on cyclic distributions of events, and on a combination of these. BSS was also similar for the three types of input data, with an overall mean BSS of 0.13. This study provides a characterization of the state of the art in seizure forecast algorithms along with their performances, setting a benchmark for future developments. It identified a considerable lack of standardization across study design and evaluation, leading to the proposal of guidelines for the design of seizure forecast solutions.
Thrombospondin-4 as potential cerebrospinal fluid biomarker for therapy response in pediatric spinal muscular atrophy
Authors: Dobelmann Vera , Roos Andreas , Hentschel Andreas , Della Marina Adela , Leo Markus , Schmitt Linda-Isabell , Maggi Lorenzo , Schara-Schmidt Ulrike , Hagenacker Tim , Ruck Tobias , Kölbel Heike 
Published: September 2024

Abstract
Background and purpose
Spinal muscular atrophy (SMA) as the second most common neurodegenerative disorder in childhood is characterized by the deficiency of survival of motor neuron (SMN) protein leading predominantly to degeneration of alpha motor neurons and consequently to progressive muscle weakness and atrophy. Besides some biomarkers like SMN2 copy number therapeutic biomarkers for SMA with known relevance for neuromuscular transmission are lacking. Here, we examined the potential of Thrombospondin-4 (TSP4) to serve as a cerebrospinal fluid (CSF) biomarker, which may also indicate treatment response.

Methods
We used untargeted proteomic analyses to determine biomarkers in CSF samples derived from pediatric pre-symptomatic (n = 6) and symptomatic (n = 4) SMA patients. The identified biomarker TSP4 was then validated in additional 68 CSF samples (9 adult and 24 pediatric SMA patients, 5 adult and 13 pediatric non-disease controls in addition to 17 pediatric disease controls) by enzyme-linked immunosorbent assay (ELISA) as an additional analytical approach.

Results
Untargeted proteomic analyses of CSF identified a dysregulation of TSP4 and revealed a difference between pre-symptomatic SMA patients and patients identified after the onset of first symptoms. Subsequent ELISA-analyses showed that TSP4 is decreased in pediatric but not adult SMA patients. CSF of pediatric patients with other neurological disorders demonstrated no alteration of TSP4 levels. Furthermore, CSF TSP4 levels of pediatric SMA patients increased after first dose of Nusinersen.

Conclusions
We found that TSP4 levels are exclusively reduced in CSF of pediatric SMA patients and increase after treatment, leading us to the hypothesis that TSP4 could serve as a CSF biomarker with the potential to monitor treatment response in pediatric SMA patients. Moreover, TSP4 enable to distinguish pre-symptomatic and symptomatic patients suggesting a potential to serve as a stratification marker.
The complex neurochemistry of the cockroach antennal heart
Authors: Agricola Hans , Bräunig Peter 
Published: September 2024

AbstractThe innervation of the antennal heart of the cockroach Periplaneta americana was studied with immunocytochemical techniques on both the light and electron microscopic levels. The antennal heart is innervated by two efferent systems, both using one biogenic amine in combination with neuropeptides. In one, we found co-localization of serotonin with proctolin and allatostatin. These fibers most likely originate from paired neurons located in the suboesophageal ganglion. In the second system, we found octopamine co-localized with the short neuropeptide F. The source of this second system is dorsal unpaired median (DUM) neurons, also located in the suboesophageal ganglion. The possible effects of these neuromediators on different targets are discussed.
Eine stark korrodierte Römische Münze aus Kupfer-Blei von Carnuntum
Authors: Pronina Angelina , Strobl Susanne , Haubner Roland 
Published: September 2024

ZusammenfassungEine stark korrodierte Römische Kupfermünze aus Carnuntum, Österreich, ist Gegenstand der Untersuchung. Es könnte sich um eine Münze des Kaisers Gratian oder des Kaisers Magnus Maximus handeln. Eine Besonderheit der Münze ist, dass sie aus einer Kupfer-Blei Legierung ohne weitere Legierungszusätze besteht.Eine ausgeprägte Längsstruktur und ein feines Kupfergefüge lassen vermuten, dass nach der Herstellung des Münzrohlings keine Glühbehandlung mehr erfolgte.Zuguterletzt wurde noch die korrosionsbedingte Entstehung von PbCl2 nachgewiesen.
Vortioxetine in children and adolescents with major depressive disorder: 6-month and 18-month open-label, flexible-dose, long-term extension studies
Authors: DelBello Melissa P. , Findling Robert L. , Huss Michael , Necking Oscar , Petersen Maria L. , Schmidt Simon N. , Rosen Monika 
Published: September 2024

AbstractChildren and adolescents with severe or relapsing major depressive disorder (MDD) may require long-term antidepressant use, but safety and tolerability data on long-term treatment are limited. In a randomized, placebo-controlled trial in children and another in adolescents, vortioxetine and placebo groups showed improvement in MDD symptoms without statistically significant differences between groups. To gain insights on long-term safety and tolerability of vortioxetine in pediatric patients, participants from these two studies were enrolled in two long-term extension studies: 6 months (NCT02871297) followed by another 18 months (NCT03108625). Key safety measures included adverse events (AEs) and Columbia-Suicide Severity Rating Scale (C-SSRS); effectiveness measures included depression symptom severity, cognitive function, and overall functioning. Among the 662 patients in the 6-month extension, 61% experienced a treatment-emergent AE (TEAE), with the most common being nausea (20.8%); 2.1% had a serious AE (SAE), and 6% withdrew because of TEAEs. In the following 18-month extension (n = 94), 51% of patients experienced a TEAE, with the most common being headache (13.8%); no SAEs were reported. Based on the C-SSRS, 94% and 96% of patients reported no suicidal ideation or behavior in the 6- and 18-month studies, respectively. During the extension studies, patients continued to show improvement in depressive symptoms and cognitive and overall functioning, with > 50% of patients in remission at the end of each study, regardless of study treatment in the lead-in trial. Overall, vortioxetine remained well tolerated in pediatric patients with MDD who continued in the long-term extension studies with no observed increased risk in suicidal ideation.
Modelling a storage system of a wind farm with a ramp-rate limitation: a semi-Markov modulated Brownian bridge approach
Authors: Azze Abel , D’Amico Guglielmo , D’Auria Bernardo , Vergine Salvatore 
Published: September 2024

Abstract
We propose a new methodology to simulate the discounted penalty applied to a wind-farm operator by violating ramp-rate limitation policies. It is assumed that the operator manages a wind turbine plugged into a battery, which either provides or stores energy on demand to avoid ramp-up and ramp-down events. The battery stages, namely charging, discharging, or neutral, are modeled as a semi-Markov process. During each charging/discharging period, the energy stored/supplied is assumed to follow a modified Brownian bridge that depends on three parameters. We prove the validity of our methodology by testing the model on 10 years of real wind-power data and comparing real versus simulated results.
Assessing Callous-Unemotional Traits Across Early Adolescence: Further Evaluation of Short Versions
Authors: Corbelli Giuseppe , Levantini Valentina , Muratori Pietro , Senese Vincenzo Paolo , Bravaccio Carmela , Pisano Simone , Catone Gennaro , Paciello Marinella 
Published: September 2024

AbstractLiterature on the Inventory of Callous-Unemotional (ICU) traits has suggested different versions of the instrument for assessing these traits during development. However, consensus on the instrument version and the best factorial solution remains a matter of debate, with only a few studies having validated ICU versions from a longitudinal perspective. The current study aims to contribute to the literature by comparing ICU models in a longitudinal sample of early adolescents (N = 739; 70.6% of eligible subjects, 371 females and 368 males, in the 6th grade at baseline assessment and in the 8th grade at the second assessment). We tested the validity of various versions of the ICU scales and their respective dimensions by conducting a series of confirmatory factor analyses to verify the factor structure, alongside assessments of internal consistency. For the best-fitting structure, we then analyzed gender and longitudinal invariance in addition to construct and predictive validity, using internalizing and externalizing criteria as well as prosocial behavior. From the comparative analysis, it emerged that the abbreviated 11-item ICU scale version displayed overall better data fit than the full 24-item version. Moreover, its confirmed gender invariance underscores its applicability across genders within the studied age group. With regard to longitudinal invariance, our findings advise caution when comparing ICU scores across early adolescence. Practical implications are discussed.
Convergence of a quasi-Newton method for solving systems of nonlinear underdetermined equations
Authors: Vater N. , Borzì A. 
Published: September 2024

AbstractThe development and convergence analysis of a quasi-Newton method for the solution of systems of nonlinear underdetermined equations is investigated. These equations arise in many application fields, e.g., supervised learning of large overparameterised neural networks, which require the development of efficient methods with guaranteed convergence. In this paper, a new approach for the computation of the Moore–Penrose inverse of the approximate Jacobian coming from the Broyden update is presented and a semi-local convergence result for a damped quasi-Newton method is proved. The theoretical results are illustrated in detail for the case of systems of multidimensional quadratic equations, and validated in the context of eigenvalue problems and supervised learning of overparameterised neural networks.
Charting the BRIC countries’ connection of political stability, economic growth, demographics, renewables and CO2 emissions
Authors: Oprea Simona-Vasilica , Georgescu Irina Alexandra , Bâra Adela 
Published: September 2024

AbstractThis research examines the impact of economic policy uncertainty, GDP, population and renewable energy consumption on CO2 emissions in BRIC countries from 1991 to 2023. The objective is to understand the long-term relationships among these variables and provide relevant insights. Using fully modified ordinary least squares and dynamic ordinary least squares econometric methods, the findings reveal that GDP and population growth significantly increase CO2 emissions, while renewable energy consumption reduces them. The panel autoregressive distributed lag results highlight the need for policies promoting renewable energy and managing population growth to mitigate environmental impacts. Notably, economic policy uncertainty also contributes to higher emissions, underscoring the importance of stable economic policies.
Assessing the Readiness of Rural Public Librarians to Implement Public Health Programs
Authors: Lenstra Noah , Franklin Heather , Dieckmann Nathan F. , Andreyeva Elena , Maddock Jay , Seguin-Fowler Rebecca A. , Winkle Jim , Perry Cynthia K. 
Published: September 2024

Abstract
Although health promotion is not the primary function of public libraries, it is well documented that many libraries engage in health promotion activities, even when resources are constrained. Less understood is the readiness of the public library workforce, particularly in rural communities, to implement evidence-based health promotion programs. This study uses a modified version of the Competency Assessment for Tier 2 Public Health Professionals to assess the readiness of a small sample (n = 21) of Oregon rural library managers to implement evidence-based health initiatives. Results show that outside of communication skills, most rural library workers do not consider themselves to have proficiency in core health promotion competencies. Although some slight differences were found among librarians based on socio-demographic factors, those differences were not statistically significant. Implications include the need for strengthened support to build the capacity for rural public library workers who are interested in delivering evidence-based health promotion programs.
Degrees of Legitimacy
Authors: Brinkmann Matthias 
Published: September 2024

AbstractIt is increasingly common in the philosophical literature to claim that political legitimacy, normatively understood, comes in degrees. However, most authors fail to specify what talk of degrees means, and the notion remains opaque. Using the Hohfeld schema as a guide, I survey possible accounts, distinguishing them into “width”, “depth”, and “weight” proposals. I argue that each fails to provide a convincing account of scalar legitimacy. Thus, talk of degrees of legitimacy, as currently used, is in serious need of explanation.
Why Normative Behaviourism Does Not Improve Political Realism
Authors: Erman Eva , Möller Niklas 
Published: September 2024

AbstractFocusing on ‘real actions’ of ‘real people’, normative behaviourism turns facts about observable patterns of behaviour into grounds for specific normative political principles. For this reason, this way of doing normative political theory has strong political realist credentials, given its methods, values and ambitions. In fact, according to its supporters, normative behaviourism is an improvement of political realism since it solves two problems that allegedly face many realists, namely, the ‘legitimacy problem’, i.e., how we should distinguish genuine acceptance of a political system from false acceptance, and ‘the institutional problem’, i.e., how we should translate political principles into viable political institutions. In this paper, we make two claims. First, normative behaviourism does not solve the legitimacy problem encountered by realists, because its solution rests on a flawed distinction between foundational principles and ‘principles that matter’, together with a problematic use of a Humean internal reasons approach. Second, normative behaviourism does not solve the institutional problem encountered by realists, because its solution is in fact much more unfeasible than realist prescriptions, since feasibility is interpreted as mere possibility. We wind up our analysis by showing that normative behaviourism encounters new problems that realist approaches typically do not face.
Ultrasound-guided kidney biopsy: a ten-year retrospective single-center experience and the promising role of clinical hypnosis
Authors: Angioi Andrea , Mascia Giacomo , Sirigu Danilo , Cao Riccardo , Bianco Paola , Onnis Daniela , Floris Matteo , Cabiddu Gianfranca , Pani Antonello , Lepori Nicola 
Published: September 2024

Abstract
This retrospective analysis investigates the outcomes and complications of 682 kidney biopsies performed at ARNAS G. Brotzu from 2010 to 2021. Our findings indicate a minor complication rate of 9.1%, with severe complications being exceedingly rare at 0.3%. Age did not contribute to an increased risk, underscoring the procedure’s safety across age groups. Clinical hypnosis was incorporated into the biopsy protocol in a subset of patients (n = 45) from April 2019 to December 2023. Over 90% of these patients reported no perception of the procedure, and 60% experienced no pain. According to STAY-Y test scores, this approach significantly reduced anxiety post-procedure (p = 0.001); no major or minor complications were observed in this group. While our study reaffirms the very low risk of severe complications in kidney biopsies, it also highlights the potential benefits of adjunct clinical hypnosis in enhancing patient comfort and cooperation during the procedure. This exploration opens a promising avenue for further investigation to improve patient experiences and procedural outcomes in kidney biopsies.
Mandibular device treatment in obstructive sleep apnea -A structured therapy adjustment considering night-to-night variability night-to-night variability in mandibular devices
Authors: Papenfuß Greta Sophie , König Inke R. , Hagen Christina , Frydrychowicz Alex , Zell Fenja , Ibbeken Alina Janna , Buzug Thorsten M. , Kirstein Ulrike , Kreft Lina , Grünberg Daniel , Hakim Samer , Steffen Armin 
Published: September 2024

Abstract
Background
Mandibular advancement devices (MAD) are a well-established treatment option for obstructive sleep apnea (OSA). MAD are considered preferably for patients with mild to moderate OSA presenting with a elevated night-to-night variability (NNV). This study aimed to determine the treatment effect of MAD on NNV considering different protrusion distances and patient related outcome (PRO).

Methods
We conducted a prospective cohort analysis of patients before MAD with 60% and 80% of the maximum protrusion. OSA severity was assessed using a home-sleep test for two consecutive nights. PRO contained the Epworth Sleepiness Scale (ESS) and sleep related quality of life (FOSQ).

Results
Twenty patients with a median overweight body-mass-index of 27.1 (interquartile range (IQR) 16.3 kg/m²), with a mainly mild to moderate OSA with an apnea -hypopnea index (AHI) of 18.3 / h (IQR 17.7) and elevated ESS of 12.5 (IQR 8.0) were included. As opposed to 80%, 60% protrusion significantly but not 80% relevantly reduced AHI (60%%: 11.2 (IQR 5.5)/h, p = 0.01; 80%: 12.9 (IQR18,0)/h, p = 0.32) and improved the ESS (60%: 8.0 (IQR 10,0); 80%: 10 (IQR 9.0)), with therapy settings. No correlation could be detected between NNV and ESS, and FOSQ changes. Higher baseline NNV was associated with severe OSA (p = 0.02) but not with gender, overweight, or status post-tonsillectomy.

Conclusions
OSA improvement is associated with lower NNV; both OSA and NNV are connected to the degree of protrusion. Therefore, higher NNV does not justify the exclusion of candidates for MAD treatment. PRO changes are not visibly affected by NNV but by general OSA changes. These findings may help to define and optimize future study designs for the primary outcome decision between objective OSA parameters and PRO.