bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can the Mineralization of Antibiotics from Water Bodies be a Significant Step in the Fight Against Alarming Antimicrobial Resistance?
Authors: Bhardwaj Rashi , Saha Supradip , Basu Tinku 
Published: October 2024

Introduction:
The overuse and improper disposal of antibiotics may add to the continuous rise of antimicrobial
resistance (AMR). In this work, we demonstrate a sequential effect of two novel catalytic
systems consisting of MIL-100(Fe) MOF (Metal Organic Framework) and MnO2 nanosheets to
degrade amoxicillin antibiotic through the destruction of β lactam group.

Method:
The catalysts were fabricated via chemical method. the catalysts exhibit large surface area,
excellent porosity, excellent catalytic activity, and insolubility and can be easily separable from the
reaction mixture.

Results:
The sequential use of MIL-100(Fe) MOF and MnO2 nanosheets could showcase 92% degradation
of amoxicillin within 1.5 hours under ambient conditions without any significant residual
bi-product as confirmed by LCMS studies.

Conclusion:
Impressively, the antimicrobial susceptibility of degraded residue is lessened by 33%
as compared to pure amoxicillin.
Kidney Outcomes with Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter 2 Inhibitors, Dipeptidyl Peptidase-4 Inhibitors, and Sulfonylureas in Type 2 Diabetes and Moderate Cardiovascular Risk
Authors: Neumiller Joshua J. , Herrin Jeph , Swarna Kavya Sindhu , Polley Eric C. , Galindo Rodolfo J. , Umpierrez Guillermo E. , Deng Yihong , Ross Joseph S. , Mickelson Mindy M. , McCoy Rozalina G. 
Published: October 2024

Key Points

Sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists were superior to dipeptidyl peptidase-4 inhibitor and sulfonylurea for preventing kidney complications in patients with type 2 diabetes at moderate cardiovascular disease risk.Sodium-glucose cotransporter 2 inhibitor therapy compared favorably with glucagon-like peptide-1 receptor agonists for kidney disease outcomes.

Background
CKD is a serious diabetes-related complication. While guidelines recommend use of sodium-glucose cotransporter 2 inhibitor (SGLT2i) and glucagon-like peptide-1 receptor agonist (GLP-1RA) therapies to mitigate cardiorenal risk in high-risk patients, the benefit of early initiation of these agents relative to other commonly prescribed glucose-lowering agents in patients at lower baseline cardiovascular disease (CVD) risk remains less clear.

Methods
This retrospective observational study emulated an idealized target trial using claims data from OptumLabs data warehouse to test the comparative association of treatment with a dipeptidyl peptidase-4 inhibitor (DPP-4i), SGLT2i, GLP-1RA, or sulfonylurea (SU) on a primary kidney composite outcome of incident CKD stages 3–5, kidney failure, or need for KRT in patients with type 2 diabetes and moderate CVD risk. A secondary composite outcome included all components of the primary composite outcome plus death.

Results
A total of 364,714 adults aged 21 years or older initiating treatment with a DPP-4i (N=78,843), GLP-1RA (N=42,049), SGLT2i (N=45,466), or SU (N=198,356) were identified. Relative to DPP-4i, SGLT2i (hazard ratio [HR], 0.71; 95% confidence interval [CI], 0.67 to 0.74; P < 0.001) and GLP-1RA (HR, 0.87; 95% CI, 0.83 to 0.92; P < 0.001) treatment was superior for the primary composite outcome. Similarly, SGLT2i (HR, 0.69; 95% CI, 0.66 to 0.73) and GLP-1RA (HR, 0.86; 95% CI, 0.82 to 0.91) treatment was associated with risk reductions for the primary outcome relative to SU treatment. When comparing SGLT2i with GLP-1RA therapy, SGLT2is were superior for the primary composite outcome (HR, 0.81; 95% CI, 0.75 to 0.86; P < 0.001). Similar findings were observed for the secondary composite outcome across all comparisons.

Conclusions
SGLT2is and GLP-1RAs were superior to DPP-4is and SUs for preventing kidney complications in a type 2 diabetes population with moderate baseline CVD risk.

Clinical Trial registry name and registration number:

NCT05214573.
Modelación mediante PWC debido a la presencia de plaguicidas organoclorados en los canales de Ampampilco y Apatlaco, Xochimilco
Authors: Salas Ramírez Ricardo Iván , García  Villanueva Luis Antonio , Fernández Villagómez Georgina , Guadarrama Guzmán Pedro , Rodrigo Ilarri Javier 
Published: October 2024

Despite the fact that the use and application of most organochlorine pesticides has been prohibited in Mexico, these are still been used in several cultivation areas, such as Xochimilco´s Chinampera area, specifically in the Apatlaco and Ampampilco canals. Consequently, this study reports the data found in these canals and a comparison has been made with respect to PWC modeling and international standards. The above-mentioned program estimates the concentrations that should be found in these canals if the pesticides were applied according to the recommendations. The aim of this paper is to explain what happens in the study area by comparing the calculated theoretic concentrations from each of the organochlorine pesticides, when using the Pesticide in Water Calculator (PWC), with those detected in water and surface soil and taking into account as established by international regulations. Results show that the concentrations for aldrin and dieldrin exceed the CCME limits, not so for the EPA, and for the EC the dieldrin is in acceptable limits, the aldrin exceeds these limits. Therefore, it is necessary to have a careful control and monitoring over the use of these pesticides. Endosulfan exceeds in the three international standards (CCME, EPA and CE), since it presents high levels in the calculations made with PWC.
Effects of Adopting Preventive Drug Lists on Medication Costs and Disparities by Income Over 2 Years: A Natural Experiment for Translation in Diabetes (NEXT-D) Study
Authors: Lu Christine Y. , Argetsinger Stephanie , Lakoma Matthew , Zhang Fang , Wharam J. Frank , Ross-Degnan Dennis 
Published: October 2024

OBJECTIVE
To examine the association between preventive drug lists (PDLs) and changes in medication costs among patients with diabetes insured in commercial health plans over 2 follow-up years.

RESEARCH DESIGN AND METHODS
We conducted a quasiexperimental study using the Optum deidentified Clinformatics Data Mart Database (January 2003 to December 2017). The intervention group included 5,582 patients with diabetes age 12–64 years switched by employers to PDL coverage; the control group included 5,582 matched patients whose employers offered no PDL. Outcomes included out-of-pocket costs, standardized costs, and 30-day fills for all medications because PDL-associated savings could be used to pay for medicines in other classes and for five therapeutic classes covered by the PDLs (oral diabetes medications, insulins, test strips, antihypertensive drugs, and lipid-lowering drugs).

RESULTS
Pre– to post–out-of-pocket spending for all medications declined by 29.7% in follow-up year 2 (95% CI −36.0, −23.4%) among PDL members relative to control individuals. Higher-income and lower-income PDL members experienced significant reductions in out-of-pocket spending for all medications in year 2 (30%) and for key therapeutic classes (range −23 to −67%). We found significant increases in use of key therapeutic classes in the overall population (range 8–15%) and in higher-income and lower-income PDL members (range 9–50%).

CONCLUSIONS
PDLs offer an effective strategy for employers and insurers to lower member cost sharing and encourage increased use of important medications to prevent or manage chronic illnesses. For patients with diabetes, especially those with lower incomes, PDL coverage resulted in substantial and persistent reductions in out-of-pocket medication costs, medication use increases, and some increased use of more expensive products.
Association of Energy Intake and Dietary Glycemic Load in Different Time Periods With Cardiovascular Disease Mortality Among U.S. Adults With Type 2 Diabetes
Authors: Dai Jin , Nianogo Roch , Moin Tannaz , Wong Nathan D. , Qi Qibin , Sotres-Alvarez Daniela , Chen Liwei 
Published: October 2024

OBJECTIVE
To examine the associations of energy intake and glycemic load (GL) in different time periods during the day with cardiovascular disease (CVD) mortality risk in adults with type 2 diabetes.

RESEARCH DESIGN AND METHODS
This cohort study included 2,911 adults with diabetes from who were part of the U.S. National Health and Nutrition Examination Survey 2003–2014 (baseline), and CVD mortality data obtained by linkage to the National Death Index through 2019. Energy intake and GL in early morning (6:00–7:59 a.m.), late morning (8:00–10:59 a.m.), afternoon (11:00 a.m.–5:59 p.m.), evening (6:00–11:59 p.m.), and night (0:00–5:59 a.m.) were derived from two 24-h dietary recalls at baseline. Cox models were used to estimate hazard ratios (HRs) for CVD mortality, adjusted for total energy intake, diet quality, sociodemographic and lifestyle characteristics, and medical conditions.

RESULTS
At baseline, the study population (51.8% female, 62.3% non-Hispanic White) had a mean age of 57.4 (SE, 0.4) years. Over a median follow-up of 9.3 (interquartile range = 6.8, 12.1) years, 190 CVD deaths were documented. Energy intake and GL in late morning were inversely associated with CVD mortality risk (per 100-kcal energy intake increment, HR 0.90 [95% CI 0.83–0.98]; per 10-unit GL increment, HR 0.86 [95% CI 0.77–0.95]). In contrast, energy intake and GL at night were positively associated with CVD mortality risk (per 100-kcal energy intake increment, HR 1.22 [95% CI 1.07–1.40]; per 10-unit GL increment, HR 1.44 [95% CI 1.17–1.77]).

CONCLUSIONS
For adults with type 2 diabetes, late morning may be a protective eating time against CVD mortality, whereas night may be a detrimental eating time.
The prevalence of intervertebral disc degeneration in the cervical, thoracic, and lumbar spine in asymptomatic cats
Authors: Schmid David , Lanzillotta Valentina , Evans Richard , Steffen Frank , Smolders Lucas A. 
Published: October 2024

Abstract

OBJECTIVE
To investigate the prevalence and severity of intervertebral disc (IVD) degeneration (IVDD) throughout the spine of young, middle-aged, and old asymptomatic cats; identify differences between the cervical, thoracic, and lumbar spine; and investigate the influence of sex and neuter status on the prevalence of feline IVDD.

METHODS
60 cadavers were collected from asymptomatic cats and subdivided into 3 age groups: young (≥ 1 to < 6 years), middle aged (≥ 6 to < 12 years), and old (≥ 12 years). T2 weighted sagittal MRI studies of the spine were obtained. Each IVD was graded according to the modified Pfirrmann grading for feline IVDD. Cumulative link mixed models were used to analyze the significance of spinal region, age, sex, and neuter status on the degenerative state of the IVDs.

RESULTS
A total of 1,544 IVDs were evaluated; 884 (57.3%), 425 (27.5%), 147 (9.5%), 82 (5.3%), and 6 (0.4%) were graded Pfirrmann 1, 2, 3, 4, and 5, respectively. Irrespective of spinal region, middle-aged cats (OR, 4.03; P < .01) and old cats (OR, 12.5; P < .01) had significantly higher odds for IVDD compared to young cats. For old cats, thoracic (OR, 4.44; P < .01) and cervical IVDs (OR, 2.76; P < .01) had significantly higher odds of degenerating compared to lumbar IVDs. No significant effect of sex (P = .81) and neuter status (P = .61) was found.

CLINICAL RELEVANCE
The prevalence of feline IVDD significantly increases with progressive age, with the thoracic and cervical IVDs showing the highest odds for degeneration. However, extreme stages of IVDD were only occasionally observed.
RELATIONSHIP BETWEEN TOOTH BRUSHING BEHAVIOR AND DENTAL CARIES IN CHILDREN AT 27 SUNGAI SAPIH PUBLIC ELEMENTARY SCHOOL KURANJI, PADANG CITY
Authors: Utami Sri Pandu Pandu 
Published: October 2024

Caries is often experienced in mid-childhood 10-12 years which is referred to as a vulnerable period, because it is at that time that milk teeth begin to fall out and the first permanent teeth begin to grow. The 2018 West Sumatra Basic Health Research Results ( Rikesdas ) stated that 41.74% of children aged 10-14 years experience dental caries, while the prevalence of dental caries in Padang City is around 6,154 children, which is 36.71% . The behavior of maintaining community dental health in maintaining oral health is brushing teeth, while brushing teeth is the most important primary prevention action recommended . Research objectives to find out relationship between tooth brushing behavior and dental caries in children at 27 Sungai Sapih Public Elementary School Kuranji, Padang City . The type of research used is quantitative research, namely analytic with an observation approach . The population in this study were all students in grades 4 and 5 at State Elementary School 27 Sungai Sapih Kuranji Padang City, totaling 114 people with total sampling technique. This research was conducted at 27 Sungai Sapih Public Elementary School Kuranji, Padang City. When the research was conducted in November 2022 -February 2023 . Analysis data using Spearman test, data processing using computerized program SPSS IBM version 25.0 . The results of the study showed that the most tooth brushing behavior was moderate, namely 94 people (82.5%), the most dental caries was very low, namely 56 people (49.1%) and there were relationship between tooth brushing behavior and dental caries in children at 27 Sungai Sapih Public Elementary School Kuranji, Padang City. ( p = 0.001 ) . It is recommended for dental health workers to educate schools about the importance of dental and oral care and how to brush their teeth properly and correctly so that they can increase students' knowledge and behavior in brushing their teeth for the better.
KORELASI STATUS GIZI DAN POLA ASUH DENGAN KECERDASAN INTELEKTUAL PESERTA DIDIK SDN 04 BOJONGSARI
Authors: Hanifah Mayang Putri , Nugrohowati Nunuk , Savitri Pritha Maya , Kristanti Melly 
Published: October 2024

Kecerdasan intelektual adalah kemampuan seseorang untuk memahami, memproses, dan menggunakan informasi secara efektif. Angka harapan lama sekolah dan rata-rata lama sekolah di Bojongsari cukup rendah, yaitu 13.91 dan 10.52 pada tahun 2021 yang kurang dari target UNDP sebesar 18 dan 15. Status gizi dan pola asuh memengaruhi kecerdasan intelektual. Status gizi merupakan keseimbangan antara asupan dan kebutuhan zat gizi tubuh. Salah satu indeksnya ialah TB/U, di mana angka kejadian stunting di Bojongsari tahun 2022 tertinggi di Depok sebesar 6%. Pola asuh demokratis dianggap paling tepat, namun pola asuh non-demokratis yang paling banyak ditemui di Depok. Tujuan dari penelitian ini untuk mengetahui korelasi status gizi dan pola asuh dengan kecerdasan intelektual peserta didik SDN 04 Bojongsari. Desain Cross-sectional digunakan dalam penelitian ini. Populasi penelitian ini adalah seluruh peserta didik SDN 04 Bojongsari, dengan jumlah sampel sebanyak 70 responden yang diambil secara Stratified random sampling. Variabel dependen penelitian ini adalah kecerdasan intelektual, sedangkan status gizi dan pola asuh adalah variabel independen. Analisis univariat dan bivariat digunakan dalam analisis penelitian ini dengan uji spearman. Hasil univariat didapatkan IQ kategori average 54,3%, stunting 25,7%, underweight 30%, wasting 25,7%, dan pola demokratis 72,9%. Hasil bivariat menunjukkan tidak terdapat korelasi yang signifikan antara status gizi dengan IQ (P-value = 0.565). Sementara itu, terdapat korelasi yang signifikan antara pola asuh dengan IQ (P-value = 0,004; koefisien korelasi = 0,341). Ditemukan bahwa hanya pola asuh yang berkorelasi dengan kecerdasan intelektual. Oleh karena itu, dapat disimpulkan bahwa penerapan pola asuh yang tepat akan meningkatkan kecerdasan intelektual anak.
Kata kunci : Kecerdasan intelektual, status gizi, stunting, pola asuh, Bojongsari
HUBUNGAN DURASI AKTIVITAS FISIK JARAK DEKAT DENGAN ASTENOPIA PADA MAHASISWA PENDIDIKAN DOKTER UNIVERSITAS UDAYANA
Authors: Arleni Putri Ni Putu Apriliantini , Ari Suryathi Ni Made , Kusumadjaja Made Agus , Made Juliari I Gusti Ayu 
Published: October 2024

Astenopia merupakan gejala subjektif yang timbul akibat penggunaan mata dalam aktivitas fisik jarak dekat. Upaya pembatasan penyebaran COVID-19 melalui perkuliahan daring menimbulkan peningkatan penerapan digitalisasi pada mahasiswa. Digitalisasi mempengaruhi fisiologis mata, dimana banyak di antara mahasiswa mengeluhkan kelelahan mata selama perkuliahan daring yang mewajibkan penerapan aktivitas fisik jarak dekat dalam waktu yang lama. Durasi aktivitas fisik jarak dekat yang berlebih menimbulkan ketidaknyamanan dan gerakan mata yang sering serta berisiko timbulnya astenopia. Penelitian ini untuk mengetahui hubungan durasi aktivitas fisik jarak dekat sebagai faktor risiko timbulnya astenopia Mahasiswa Fakultas Kedokteran Universitas Udayana yang menerapkan desain studi observasional dengan pendekatan analitik cross-sectional yang melibatkan 653 mahasiswa Pendidikan Dokter angkatan 2018-2020 Universitas Udayana. Pengambilan sampel sesuai pertimbangkan, yaitu purposive sampling. Bahan penelitian sesuai dengan data primer berupa kuesioner VFI (Visual Fatigue Index). Dari 653 mahasiswa Pendidikan Dokter angkatan 2018-2020 Universitas Udayana yang terlibat sebagai responden ditemukan sebanyak 465 mahasiswa (71,2%) mengalami astenopia. Rata-rata durasi aktivitas fisik jarak dekat yang yaitu pada durasi ? 4 jam. Hasil penelitian menunjukkan bahwa tiga aktivitas fisik jarak dekat yang diteliti meliputi, membaca, penggunaan smartphone, dan laptop atau komputer menunjukkan p value <0,05 dan nilai risk estimate PR>1, serta selang kepercayaan tidak melewati 1. Dalam penelitian ini ditemukan hubungan yang signifikan antara durasi aktivitas fisik jarak dekat dengan astenopia mahasiswa. Dalam penelitian ini disimpulkan bahwa terdapat hubungan bermakna antara durasi aktivitas fisik jarak dekat dengan astenopia pada mahasiswa Pendidikan Dokter angkatan 2018-2020 Universitas Udayana.

Kata kunci : Astenopia, Aktivitas Fisik Jarak Dekat, Durasi
Der Körper als Ort der Schmerzen – Die »Performing Art« Marina Abramovićs und Robert Wilsons als Arbeit an der Erinnerung des Körpers
Authors: Engelhardt Stephan 
Published: October 2024

Marina Abramović fügt sich Schmerzen zu. Sie schneidet sich, peitscht sich aus, kämmt sich, bis sie blutet und wir als Publikum schauen zu. Diese körperlichen Torturen sind echt und finden als Performance in einer Galerie statt. Marina Abramović ist die Darstellerin, und wir das Publikum. Dieses symbolische Geschehen folgt einer sozialen Übereinkunft und kann nicht mit der alltäglichen Wirklichkeit verwechselt werden. Was machen diese beobachteten schmerzhaften körperlichen Vorgänge mit uns? In der primären mimetischen Resonanz fühlen wir für einen Moment den Schmerz so, als wenn er unser eigener wäre. Die Sprache des Körpers wird durch ein physisches Nachempfinden dechiffriert. Der Körper ist der Ort, die mimisch-gestischen Ausdrucksmöglichkeiten seine Sprache. Die Schmerzen als Mitteilungen werden ohne Worte verstanden. Auf der körperlichen Ebene ermöglicht die mimetische Resonanz eine unmittelbare Interaktion. Alle Beteiligten sind für einen Moment miteinander verbunden und teilen ein gemeinsames Gefühl. Die schmerzhaften körperlichen Vorgänge der Marina Abramović lösen als Foto oder Film bei uns eine vergleichbare Reaktion aus. Wir reagieren in der sekundären mimetischen Resonanz so, als wenn das Abbild des selbstverletzenden Spiels eine konkrete physische Realität wäre.
Robert Wilson erzählt in der Oper »The Life and Death of Marina Abramović« die Biografie der Künstlerin. Aus der traumatisierenden Kindheit, der künstlerischen Arbeit mit ihrem Körper macht er ein Theaterstück. Die physischen Vorgänge werden nicht direkt wiedergeben, sondern in ein abstraktes Zeichensystem aus Licht, Bewegung, Worten und Musik überführt. Die schmerzhaften Gefühle werden in die Sprache der theatralen Bühnenillusion übersetzt. Als betrachtende Person ergänzen wir das Gesehene, imaginieren das Dargestellte weiter und folgen der Erzählung der Schmerzen, als wäre es ein Traum und das von uns Weiterimaginierte konkret. In dieser imaginativen tertiären mimetischen Resonanz erleben alle gemeinsam auf eine mittelbare Weise einen Moment einer intensiven Gegenwart. Diese drei unterschiedlichen Formen der mimetischen Resonanz finden im therapeutischen Prozess zufällig statt oder werden in der Methode der szenischen Imagination mit Absicht herbeigeführt.In einer medial geprägten Wirklichkeit, in der die Zeichen auf keine konkreten Erfahrungen mehr verweisen und so bedeutungslos werden, schafft diese unmittelbare physische Erfahrung und das Wiedererleben einer physischen Erfahrung, die einmal tatsächlich gesammelt wurde, eine verlässliche Wirklichkeit im Hier und Jetzt. So wird der Körper zum Ort, um etwas neues denken zu können.
SISTEM INFORMASI AKUNTANSI PROSES BISNIS JOB ORDER PADA PERUSAHAAN JASA
Authors: Purwatiningsih Esty , Sumarna Alfonsa Dian 
Published: October 2024

Accounting information systems are very important for newly established micro start-ups. Especially operational standards for main business processes. This can help start-ups carry out their business processes in a structured, orderly, controlled, and standardized manner. This applied research discusses the preparation of job order procedures that can be applied to a micro start-up business in production house services. This research aims to create accounting information systems and organize a simple job order transaction workflow with robust internal control. Procedures are prepared narratively and in flowchart form for each job order type transaction that occurs by applying the principles of effective and efficient internal control. This research method is descriptive qualitative. It can be concluded that micro start-up businesses need to have job order procedures in the form of written narratives or the form of flowcharts and also bookkeeping, which contain elements of an internal control system to adapt to the limited resources available in this micro start-up business. Keywords: Accounting Information System, Job Order, Business Process
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI UNDERPRICING SAHAM PADA PENAWARAN UMUM PERDANA
Authors: Rahma Anneu Cania , Wiharno Herma , Nurhandika Arief 
Published: October 2024

This study aims to examine and analyze what factors influence stock underpricing in companies that carry out Initial Public Offerings. The research method used in this research is descriptive method and verification method. The population in this study are all companies that are conducting Initial Public Offerings in 2019-2021. The samples obtained using quota sampling are 145 companies. The analysis technique used is multiple linear regression. Data processing uses the IBM SPSS 20 program The results of this study indicate that profitability, market value, liquidity, and firm age has a negative and significant effect on stock underpricing. Capital structure has a positive and significant effect on stock underpricing. All variables in this study have significant influence on stock underpricing. Then the regression estimation results show that the predictive ability of the 5 independent variables on stock underpricing is 73%, while the remaining 27% is influenced by other factors outside the model which are not included in this analysis. Keywords: Profitability, Market Value, Capital Structure, Liquidity, Firm Age, Underpricing.