bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrospun Gelatin Fibers with a Multiple Release of Antibiotics Accelerate Dermal Regeneration in Infected Deep Burns
Authors: Chen Jianmei , Liu Zongguang , Chen Maohua , Zhang Hong , Li Xiaohong 
Published: June 2016

Electrospun fibers of hydrophilic polymers meet challenges in a rapid degradation of fiber matrices and discharge of antibiotics to comply with requirements of infection control as a dermal regeneration template. In the current study, a pH conversion process is initially developed to ensure fluent electrospinning, an efficient in situ cross‐linking of electrospun gelatin fibers with oxidized alginate and simultaneous loading of gentamicin sulfate (GS) and hydrophobic ciprofloxacin into fibers. The dual drug‐loaded fibers indicate a complete release of GS during 6 d and a sustained release of ciprofloxacin for over three weeks, and the antibiotics release indicates significant growth inhibitions on Pseudomonas aeruginosa and Staphylococcus epidermidis. The wound healing efficacy is evaluated on a deep burn model infected with 108 CFU of P. aeruginosa. Compared with fibers with loaded individual drugs, the concomitant release of GS and ciprofloxacin significantly reduces the bacteria numbers in wound and livers, at around 2.30 × 105 and 1.25 × 103 CFU after 3 d, respectively. The wound re‐epithelization, blood vessel formation, collagen deposition, and tissue remodeling process are accelerated with a complete healing observed after 21 d. This study provides a feasible strategy to design cross‐linked hydrophilic fibers with an extended drug release for biomedical applications.
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Switching the Stiffness of Polyelectrolyte Assembly by Light to Control Behavior of Supported Cells
Authors: Ulasevich Sviatlana A. , Brezhneva Nadzeya , Zhukova Yulia , Möhwald Helmuth , Fratzl Peter , Schacher Felix H. , Sviridov Dmitry V. , Andreeva Daria V. , Skorb Ekaterina V. 
Published: June 2016

Polyelectrolyte block copolymer micelles assembled thin film is switched in response to local photocatalytic reactions on titanium dioxide, resulting in a layer of variable height, stiffness in response to visible light irradiation. Preosteoblasts migrate toward stiffer side of the substrates.image
A framework for transitioning patients from pediatric to adult health settings for patients with neurogenic bladder
Authors: Lewis Jennifer , Frimberger Dominic , Haddad Emily , Slobodov Gennady 
Published: June 2016

BackgroundAdolescents with neurogenic bladder are a vulnerable population that severely lacks consistent transitional care from pediatric to adult urology settings.AimsOur practice determined that 100 patients with spina bifida and other neurogenic bladder conditions were not appropriately transferred to the adult setting once reaching adulthood.MethodsWe initiated a transitional program to establish a dedicated and formal process for adolescent patients to transition to adult urology. The REACH clinic implements a formalized staging framework to facilitate migration of adolescents and young adults to the adult health setting. A social worker was incorporated to act as a patient advocate, behavioral health consultant, and resource specialist.ResultsTo date 45 patients have been enrolled in the transition program. We have identified and categorized according to the appropriate stage. The REACH clinic has appropriately outlined the goals and mission of the program and resources utilized are financially practical and feasible by conducting a monthly combined clinic. The program has been instrumental in improving tracking and monitoring of these patients through their transition period.ConclusionThrough the efforts of the pediatric and adult urology teams, the REACH program is a dedicated framework that provides structure for transition of the adolescent patient. The addition of a social worker has resulted in enriched rapport and will likely result in improved compliance. This program allows for surveillance and evaluation of patient outcome indicators in this patient population. We believe that early introduction and frequent encounters with the adult urologic team is crucial to successful transitions. Neurourol. Urodynam. 36:973–978, 2017. © 2016 Wiley Periodicals, Inc.
An extended boundary element method formulation for the direct calculation of the stress intensity factors in fully anisotropic materials
Authors: Hattori G. , Alatawi I. A. , Trevelyan J. 
Published: June 2016

SummaryWe propose a formulation for linear elastic fracture mechanics in which the stress intensity factors are found directly from the solution vector of an extended boundary element method formulation. The enrichment is embedded in the boundary element method formulation, rather than adding new degrees of freedom for each enriched node. Therefore, a very limited number of new degrees of freedom is added to the problem, which contributes to preserving the conditioning of the linear system of equations. The Stroh formalism is used to provide boundary element method fundamental solutions for any degree of anisotropy, and these are used for both conventional and enriched degrees of freedom. Several numerical examples are shown with benchmark solutions to validate the proposed method. Copyright © 2016 John Wiley & Sons, Ltd.
A nonparametric probabilistic approach for quantifying uncertainties in low‐dimensional and high‐dimensional nonlinear models
Authors: Soize C. , Farhat C. 
Published: June 2016

SummaryA nonparametric probabilistic approach for modeling uncertainties in projection‐based, nonlinear, reduced‐order models is presented. When experimental data are available, this approach can also quantify uncertainties in the associated high‐dimensional models. The main underlying idea is twofold. First, to substitute the deterministic reduced‐order basis (ROB) with a stochastic counterpart. Second, to construct the probability measure of the stochastic reduced‐order basis (SROB) on a subset of a compact Stiefel manifold in order to preserve some important properties of a ROB. The stochastic modeling is performed so that the probability distribution of the constructed SROB depends on a small number of hyperparameters. These are determined by solving a reduced‐order statistical inverse problem. The mathematical properties of this novel approach for quantifying model uncertainties are analyzed through theoretical developments and numerical simulations. Its potential is demonstrated through several example problems from computational structural dynamics. Copyright © 2016 John Wiley & Sons, Ltd.
Response of Blue Rubber Bleb Nevus Syndrome to Sirolimus Treatment
Authors: Salloum Ralph , Fox Courtney E. , Alvarez‐Allende Carlos R. , Hammill Adrienne M. , Dasgupta Roshni , Dickie Belinda H. , Mobberley‐Schuman Paula , Wentzel Mary Sue , Chute Carol , Kaul Ajay , Patel Manish , Merrow Arnold C. , Gupta Anita , Whitworth John R. , Adams Denise M. 
Published: June 2016

BackgroundBlue rubber bleb nevus syndrome (BRBNS) is a rare multifocal venous malformation syndrome involving predominantly the skin and gastrointestinal tract. Traditional treatment modalities include corticosteroids, interferon‐α, sclerotherapy, and aggressive surgical resection. Sirolimus has been used in several single case reports.ProcedureWe performed a single‐institution retrospective review of four children with BRBNS, who received sirolimus as part of their treatment regimens. A diagnosis of BRBNS was based on clinical, radiologic, and pathologic criteria.ResultsMedian age was 6.5 years (range: 2–16 years). Pathologic evaluations revealed a combined malformation with venous and lymphatic components. The novel finding of a lymphatic component was confirmed with PROX‐1 immunostaining. Patients received oral sirolimus with target drug levels between 10 and 13 ng/ml. Responses to treatment were defined as stabilization/decrease in size of lesions; resolution of transfusion requirements; reduction in pain, and improvement in quality of life (QOL). Median time to response was 1.5 months (SD ± 0.96 month, range: 1–3 months). Median follow‐up was 21 months (range: 18–26 months). Lesion size and characteristics improved in all patients. All patients reported decrease in pain and improvement in QOL. All three patients requiring transfusions became transfusion‐independent. One patient had resolution of coagulopathy. Adverse effects of sirolimus consisted of mucositis in three patients and neutropenia in one patient.ConclusionsSirolimus is safe and efficient for the treatment of BRBNS. Further prospective studies are needed to evaluate the long‐term effectiveness of this drug. This is the first report that identifies a lymphatic component as part of BRBNS.
Network representation of protein interactions: Theory of graph description and analysis
Authors: Kurzbach Dennis 
Published: June 2016

AbstractA methodological framework is presented for the graph theoretical interpretation of NMR data of protein interactions. The proposed analysis generalizes the idea of network representations of protein structures by expanding it to protein interactions. This approach is based on regularization of residue‐resolved NMR relaxation times and chemical shift data and subsequent construction of an adjacency matrix that represents the underlying protein interaction as a graph or network. The network nodes represent protein residues. Two nodes are connected if two residues are functionally correlated during the protein interaction event. The analysis of the resulting network enables the quantification of the importance of each amino acid of a protein for its interactions. Furthermore, the determination of the pattern of correlations between residues yields insights into the functional architecture of an interaction. This is of special interest for intrinsically disordered proteins, since the structural (three‐dimensional) architecture of these proteins and their complexes is difficult to determine. The power of the proposed methodology is demonstrated at the example of the interaction between the intrinsically disordered protein osteopontin and its natural ligand heparin.
Collecting and Analysing Data on Climate‐related Local Mobility: the MISTIC Toolkit
Authors: Safra de Campos Ricardo , Bell Martin , Charles‐Edwards Elin 
Published: June 2016

AbstractIt is widely recognised that environmental events may trigger permanent and seasonal migration but less attention has been given to the way they shape the everyday mobility that shapes household livelihood strategies. This dearth of attention can be traced to a lack of statistical data, the difficulties of collecting information on local space‐time trajectories and the absence of sound statistical measures by which to express them. We review prior work on the migration–environment nexus and trace the development of methods that aim to capture and measure temporary population movement. We identify nine discrete dimensions of mobility and introduce the Mobility in Space and Time among Individuals and Communities (MISTIC) toolkit that is designed to capture the spatio‐temporal patterns of household everyday mobility using a flexible, participant centred approach that facilitates data recording and subsequent analysis. We illustrate application of the toolkit using data from 90 smallholder, subsistence households in semi‐arid rural Northeast Brazil. The empirical evidence reveals systematic changes in the frequency and duration of both production and consumption‐related movements in response to the 2010–2013 drought. Copyright © 2016 John Wiley & Sons, Ltd.
Potential accuracy of navigated K‐wire guided supra‐acetabular osteotomies in orthopedic surgery: a CT fluoroscopy cadaver study
Authors: Postl Lukas K. , Kirchhoff Chlodwig , Toepfer Andreas , Kirchhoff Sonja , Schmitt‐Sody Marcus , von Eisenhart‐Rothe Rüdiger , Burgkart Rainer 
Published: June 2016

AbstractBackgroundThe aim of this study was to evaluate the accuracy of supra‐acetabular pelvic tumor resections in human, full‐body cadavers and under realistic operation room conditions with the help of a navigation system and K‐wires as guidance for the oscillating saw.MethodsSeven hemipelvises from fresh, human, male, full‐body cadavers were used. A preoperative and a postoperative CT was performed. Under control of the navigation system K‐wires were inserted and served as guidance for the oscillating saw to reduce the error by vibration and jerking movements. The accuracy of the computer aided resections was compared with the accuracy of freehand resections in customized 3D printed pelvises with geometries identical to the cadavers used.ResultsThe mean deviation of the navigated osteotomies was 1.9 mm (standard deviation 1.0 mm) significantly (P < 0.001) lower than the mean deviation of freehand osteotomies at 9.2 mm (standard deviation 3.7 mm).ConclusionNavigated K‐wires for supra‐acetabular osteotomies allow significantly higher accuracy than freehand procedures under simulated operation room conditions. Copyright © 2016 John Wiley & Sons, Ltd.
Exploring the Direction of Charge Transfer in Porphyrin – PbSe Quantum Dot Hybrids
Authors: Shaikh Ahson J. 
Published: June 2016

AbstractThe binding interaction of amine, thiol and carboxylic acid functionalized porphyrins to PbSe semiconductor quantum dots (QDs) has been studied by focusing on absorption and fluorescence of porphyrins in presence of PbSe QDs and absorption and fluorescence of PbSe QDs in presence of porphyrins. Only tetra‐carboxylic acid functionalized porphyrins appear to have significant binding to QDs. Fluorescence life time measurements show that the binding is dynamic rather than static, opposed to the case of metallic gold nanoparticles previously studied. QDs appear to reduce in size by dissolution, when they are exposed for longer times to porphyrins containing carboxylic acid functional groups. Transient absorption spectroscopy shows that charge transfer occurs uni‐directional from porphyrins to QDs as expected and not the other way round.
The Annulation of Vinyl Azides with Potassium Ethyl Xanthogenate: A Straightforward Synthesis of Thiazole‐2(3H)‐thiones
Authors: Rajaguru Kandasamy , Mariappan Arumugam , Muthusubramanian Shanmugam , Bhuvanesh Nattamai 
Published: June 2016

AbstractExploiting the synthetic utility of vinyl azide motif, the cascade annulation of vinyl azides with potassium ethyl xanthogenate has been demonstrated under mild and catalyst free condition to afford thiazole‐2(3H)‐thiones in good to excellent yields. The reaction features green solvent and reliable scalability with low‐cost readily available starting materials making the process eco‐friendly.
Room Temperature Ring Opening of Epoxides Over Triflic Acid Functionalized Cage Like Mesoporous Materials
Authors: Dutta Prantu , Kalita Pranjal , Baruah Pranjal K. 
Published: June 2016

AbstractHere, we have synthesized triflic acid functionalized three dimensional cage like KIT‐5 mesoporous materials for ring opening of epoxides with alcohols to produce β‐alkoxyalcohols. The mesoporosity and structure of the materials are retained, which is confirmed from characterization data of the catalysts. These data suggested the presence of triflic acid in the channel of mesoporous materials. Excellent to very good yield of the desired products were obtained using our methodology, which is due to the higher acidity of the triflic acid functionalized catalyst used. Present studies suggested that triflic acid functionalized mesoporous catalyst possessed higher catalytic activity than that of zeolites and other metal substituted mesoporous materials. The stability of the catalyst was also found to be excellent and used for three consecutive cycles without any significant lose in yield.
Integrating firefly algorithm in artificial neural network models for accurate software cost predictions
Authors: Kaushik Anupama , Tayal Devendra Kr. , Yadav Kalpana , Kaur Arvinder 
Published: June 2016

AbstractHuman effort is one of the main resources of software cost estimation. A successful software project development primarily relies on accurate effort prediction at an early stage of development. There are many effort prediction models in the literature. Deciding which model to choose is a challenge for the project managers. This paper investigates whether it is possible to improve the accuracy of software cost estimations by coupling firefly algorithm with the existing artificial neural network (ANN) models used in software cost predictions. The firefly algorithm is one of the recent evolutionary computing models inspired by the behaviour of fireflies in nature. This is compared with particle swarm optimization used already in literature for software cost estimations. The ANN models examined in this work include radial basis function network and functional link artificial neural networks models. The experimental results show that ANN models perform extremely well by incorporating firefly algorithm and intuitionistic fuzzy C‐means for data preprocessing. The proposed approach is empirically validated through a statistical framework. Copyright © 2016 John Wiley & Sons, Ltd.
Catalysis of Cascade and Multicomponent Reactions of Carbonyl Compounds and CH Acids by Electricity
Authors: Elinson Michail N. , Vereshchagin Anatoly N. , Ryzhkov Fedor V. 
Published: June 2016

AbstractThis review is concerned with modern trends in the use of electrochemically induced chain reactions in cascade and multicomponent electroorganic synthesis. The review summarizes the data on the use of electrochemically induced chain reactions in cascade and multicomponent organic synthesis, which were published mainly in the last decade.
Improving CSMA/CA network performance under hidden collision
Authors: Sebgui Marouane , Almhana Jalal , Bah Slimane , Elgraini Belhaj 
Published: June 2016

AbstractDynamic spectrum access policy allows a secondary user (SU) to access a primary user (PU) channel when it is idle. However, the idle state may result from the PU's silent activities, which can be wrongly perceived as an opportunity for the SU to access the channel and lead to “hidden collision” when it effectively tries to access the channel under this condition. At best of our knowledge, this issue has yet to be addressed in the literature. In this paper, we will first define a three‐state model that describes hidden collision conditions, then propose a probabilistic model in which a transient state is added to force the SU to wait a certain period of time before accessing the channel, thereby translating into better protection for the PU. Based on this model and using Carrier Sense Multiple Access/Collision Avoidance protocol, we will evaluate the PU's and SU's throughput and delay with and without transient state as well as the gain in using our approach. Our computation results show a substantial improvement of the PU's throughput from 19.6 to 61.1%.
Mesh adaptive direct search approach for D2D resource management
Authors: Ahmad Mushtaq , Naeem Muhammad , Ahmed Ashfaq , Iqbal Muhammad , Anpalagan Alagan 
Published: June 2016

AbstractDevice‐to‐device (D2D) communications are being considered a way forward to achieve higher data rate targets for futuristic wireless networks. D2D introduces interference among cellular users and D2D users. A joint resource allocation (JRA) strategy in cellular network with D2D functionality can definitely enhance overall data rate. The strategy under consideration maximizes the overall data rate of cellular network besides meeting threshold of power and interference constraints. The JRA is a class of mixed integer non‐linear constraint optimization problems and is NP hard. Because of discrete nature of variables in the problem, optimal solution performs extensive search of integer variables, and problem becomes exponentially complex with the increasing number of user pairs. In this paper, mesh adaptive direct search algorithm is applied to solve the aforementioned problem. The algorithm is suitable for complex problems of combinatorial nature to solve the JRA strategy in D2D. The proposed algorithm converges to optimal solution within acceptable computational iterations. Simulation results of system capacity and interference also demonstrate the suitability of the proposed approach viz‐a‐viz other algorithms. Copyright © 2016 John Wiley & Sons, Ltd.
ACL Damage and Deficiency is Associated with More Severe Preoperative Deformity, Lower Range of Motion at the Time of TKA
Authors: Berend Michael E. , Meding John B. , Malinzak Robert A. , Faris Philip M. , Jackson Michael D. , Davis Kenneth E. , Ritter Merrill A. 
Published: June 2016

Background ACL status varies in the arthritic knee during TKA. Questions/Purposes The purpose of this study was to examine clinical features and intraoperative findings associated with stages of ACL degeneration. Methods Coronal deformity, ROM, intra-articular degenerative patterns, and ligament releases were assessed for 1656 knees during TKA. Common patterns of deformity and severity of degenerative change were assessed as a function of the severity of ACL deficiency. Results Of the 1656 knees assessed, 27% had a normal ACL, 55% exhibited damage, and 18% exhibited complete absence of the ACL. Increased coronal deformity and lower preoperative ROM was associated with ACL deficiency. Increased chondral and meniscal damage and more extensive osteophyte formation were also found. More extensive ligament releases were required in ACL-deficient knees. Conclusions The status of the ACL is predictive of the need for increased surgical deformity correction. A better understanding of ACL status is an important consideration during in choosing TKA as opposed to unicompartmental arthroplasty. The status of the ACL should be considered in planning for implant choice in TKA.
Sedimentologic Attributes of the Proterozoic Siliciclastic Packages of the Garhwal – Kumaun Lesser Himalaya, India: Implication for their Relationship and Palaeobasinal Conditions
Authors: Ghosh Sumit K. , Jalal Poonam , Islam R. 
Published: June 2016

Abstract:
The present work addresses the long-standing issues on the characterization aspect of the Proterozoic siliciclastic successions exposed in the central part of the Lesser Himalaya, restricted between the Main Boundary Thrust (MBT) and the Main Central Thrust (MCT). Geologic, sedimentologic, and petrographic study divides the Lesser Himalaya in two zones-northern Palaeo-Mesoproterozoic Inner Lesser Himalayan (ILH) and southern Neoproterozoic Outer Lesser Himalayan (OLH) zones. The major lithofacies recognized from the zones are - (i) coarse grained siliciclastic (CGS), (ii) interbedded medium and fine-grained siliciclastic (IMFS), (iii) argillite (ARG), and (iv) siliciclastic–argillite rhythmites (SAR). Amongst all these facies, the nearshore IMFS facies shows consistent presence in both OLH and ILH zones. From the facies distribution pattern, a northwest – southeasterly trending palaeo-shoreline has been envisaged. The CGS facies in the ILH hints towards an alluvial fan setting during 1.8 Ga rifting phase associated with penecontemporaneous basic magmatism. Compositionally, the siliciclastics of both the zones (ILH and OLH) are arenite and wacke types with minimal variation in their detrital proportions, derived from the early Proterozoic (between 2.4-1.6Ga) Aravalli-Delhi Supergroup provenance. Nearly matching types and content of detrital modes and the lithofacies pattern of the ILH and OLH siliciclastics probably conclude the derivation from the rising (nearby) Aravalli-Delhi orogen and deposition in a foreland like situation.