bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcranial direct current stimulation: Adverse effects and the efficacy of a commonly utilised sham protocol
Authors: Kortteenniemi A. , Ali-Sisto T. , Wikgren J. , Lehto S. 
Published: June 2017

IntroductionTranscranial direct current stimulation (tDCS) is a promising neuromodulation method that has, for example, been used to treat depression. Nevertheless, the adverse effects of tDCS and the validity of the current standard tDCS sham protocols have received limited attention.ObjectivesTo evaluate the extent and types of tDCS adverse effects and to assess the reliability of sham stimulation as a control procedure for tDCS in a double-blind setting.AimsTo compare adverse effects between tDCS and sham stimulation groups, and to determine how well the participants and the experimenter are able to distinguish tDCS from sham stimulation.MethodsA sample of healthy volunteers received a 20-minute session of either tDCS (n = 41; 2 mA) or sham stimulation (n = 41; ramp up 15 s, ramp down 15 s; no current in between). The anode was placed over F3 and cathode over F4. Both the participants and the experimenter reported immediate adverse effects and the perceived likelihood for the participant to receive tDCS. Analyses were conducted using the Mann–Whitney U-test.ResultsThe tDCS group reported more erythema compared with the sham group (P = 0.016, Cohen's D = 0.444). No other significant differences in adverse effects were observed. In the tDCS group, both the participants (P = 0.034, Cohen's D = 0.612) and the experimenter (P = 0.006, Cohen's D = 0.674) reported a higher perceived likelihood of the participant receiving tDCS than in the sham group.ConclusionstDCS has only modest adverse effects. Nevertheless, the current standard sham protocol appears insufficient.Disclosure of interestThe authors have not supplied their declaration of competing interest.
A grounded theory of service providers’ perceptions of a recovery-oriented transformation of a mental health service
Authors: Eikmeier G. , Junghans T. , Kruse T. , Lacroix A. 
Published: June 2017

Recovery-oriented mental health service programs are often rather based on ideological or political considerations than on empirical evidence.At Klinikum Bremerhaven Reinkenheide, we have included peer support workers in our teams in order to improve the quality of our treatment program and the recovery attitudes of the staff members.To control and evaluate this process an independent investigator conducted 13 (T1: February 2012), respectively 15 (T2: September 2013) interviews with different stakeholders of the change process. The interviews were transcribed and analysed for the categories level of information, confidence, participation and profession/working conditions/team structure.The main result of T1 was that nursing staff fostered the projected transformation while physicians and psychologists focused on risk management and worried about losing their role. As implication of the T1 results, we offer a continuous in-house-training to improve interprofessional teamwork and social psychiatric expertise. At T2 all interviewed participants judged the involvement of the peer support workers positively. Many oft the interviewees expressed though that from their point of view their participation had decreased and/or, the reorganisation was already terminated. As implication of T2, we now try to improve our internal communication and cooperation and strengthen the involvement of all stakeholder groups.Besides the employment of peer support workers, it is essential in a recovery-oriented transformation of mental health services:– to train staff members continuously and;– to involve all stakeholder groups continuously in the change management.A third survey is projected for 2017 to implement further requirements for a successful change process.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Impact of communication on family satisfaction and anxiety in critical care
Authors: Sundararajan K. 
Published: June 2017

ObjectiveThe objectives of this study were to explore the impact of a communication course for doctors on family satisfaction and anxiety in an Australasian ICU and to elucidate the determinants of family satisfaction and anxiety.DesignProspective observational study. Pre- and post-study design.ParticipantsOne hundred and three consecutive family members of patients staying in the ICU for more than 48 hours were identified. Eighty-six subjects were evaluated and analysed.MethodsTen-point Likert scale (FS-ICU Questionnaire) used to measure satisfaction. Hospital Anxiety and Depression Scale was used to measure anxiety. Study performed over a 12-week period (9 weeks pre- and 3 weeks post-course) in a 34-bed intensive care unit before and after a communication course for junior medical officers.ResultsFifty-six subjects were approached for the purpose of this study. Forty-three family members were included, 40 of patients who survived, and 3 whose relative died in ICU. Overall family satisfaction was high (mean scores 9.44 ± 0.91). Post-course, 47 subjects were approached for the purpose of this study and 43 family members consented to participate. Overall family satisfaction was high (mean scores 9.84 ± 0.97). There was a statistically significant difference in the frequency of doctors’ communication before and after the course (P < 0.01) and anxiety levels (P = 0.0001)ConclusionThe majority of families are happy with their care in the ICU. A communication course aimed at junior medical officers was effective in improving satisfaction and reducing anxiety among family members.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Lack of insight as a third variable between subjective appraisal of cognitive impairment and psychotic symptoms
Authors: Rossi R. , Santarelli V. , Marucci C. , Gianfelice D. , Pacitti F. 
Published: June 2017

BackgroundThe relationship between subjective appraisal of cognitive deficits and symptom severity in schizophrenia is unclear. Insight reportedly impacts on both factors. Our aim is to further asses the relationship between the subjective perception of cognitive deficits, symptom severity and lack of Insight as a mediator variable.MethodsA total of 109 subject diagnosed with schizophrenia. Positive and Negative Syndrome Scale (PANSS) was modelled as dependent variable; Subjective Scale to Investigate Cognition in Schizophrenia (SSTICS) was modeled as independent variable and “Lack of Insight” (LoI) PANSS Item was tested as a mediator variable. Mediation was assessed using the Sobel Mediation Test.ResultsLoI acts as a suppressor variable (i.e. it enhances the relation between the independent and dependent variable) between SSTICS and negative symptoms, while showing a mediator effect between SSTICS and depressive symptoms.DiscussionLoI has a central role in mediating the relationship between subjective appraisal of cognitive deficits on the one hand and positive and depressed symptoms on the other. Its suppressor role between SSTICS and depression is consistent with several reports of an enhanced risk of depression in patients fully aware of their disability. Its mediator role between STICSS and positive symptoms supports the centrality of LoI as a metacognitive function whose failure may worsen psychotic symptoms.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Can neuropsychological testing facilitate differential diagnosis between at-risk mental state for psychosis and adult attention deficit hyperactivity disorder?
Authors: Studerus E. 
Published: June 2017

IntroductionPatients with an at-risk mental state (ARMS) for psychosis and patients with attention deficit hyperactivity disorder (ADHD) have many overlapping symptoms and hence can be difficult to differentiate clinically.ObjectivesThe aim of this study was to investigate whether the differential diagnosis between ARMS and ADHD could be improved by neuropsychological testing.MethodsA total of 157 ARMS and 122 adult ADHD patients were recruited via the Basel Früherkennung von Psychosen (FePsy) study and the ADHD Special Consultations Unit of the University of Basel Psychiatric Hospital, respectively. Verbal learning and memory was tested with the California Verbal Learning Test (CVLT), sustained attention with the Continuous performance test (CPT) and problem solving abilities with the Tower of Hanoi task. Group differences in neuropsychological performance were analyzed using generalized linear models, which included age and gender as covariates.ResultsAdult ADHD patients recalled significantly fewer words in the CVLT (both after short and long delay) and had significantly more false alarms and omissions and longer reaction times in the CPT than ARMS patients.ConclusionsAdult ADHD patients show larger deficits than ARMS patients in the domains of verbal memory and sustained attention, but not in problem solving abilities. This in line with current meta-analyses, which found that impairments in the domains of attention and verbal memory are of medium effect size in adult ADHD patients and of small effect size in ARMS patients. Our results suggest that measures of these domains can be exploited to improve the differential diagnosis between adult ADHD and ARMS patients.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Memory and medial temporal lobe structures in patients with schizophrenia and their siblings
Authors: Vorackova V. , Mohr P. , Knytl P. , Fajnerova I. , Dorazilova A. , Kratochvilova Z. , Skoch A. , Rodriguez M. 
Published: June 2017

Episodic retrieval is characterized by the subjective experience of remembering. Semantic memory, on the other hand, is a more structured record of facts, meanings, concepts and knowledge about the external world that we have acquired. The medial temporal lobe (MTL), especially the hippocampus and parahippocampal cortex, plays a central role in both types of memory process. Published studies suggested that individuals with schizophrenia have deficits in episodic and semantic memory, as well as structural abnormalities of the medial temporal lobe. However, it is not clear whether reported correlations reflect the impact of the disease state or that of underlying genetic influences contributing to the risk. To understand better etiology and effects of psychosis on the global brain structure and cognitive processing, relatives of individuals with schizophrenia can be studied. The aim of our study was to examine the association between abnormalities of the MTL, psychopathology, and memory impairment in schizophrenia. Study sample (n = 60) consisted of first episode schizophrenia patients, their non-psychotic siblings and matching control subjects. We used high-resolution magnetic resonance imaging and probabilistic algorithms for image analysis. Episodic and semantic memory was measured with neuropsychological tests. Our results showed differences in memory performance between the groups. Neuropsychological data were correlated with MRI findings. The results may provide insight into etiology of schizophrenia and its effects on cognition and help to identify neuroanatomical and cognitive endophenotypes of psychotic disorders.Supported by the grant projects MH CR AZV 15-28998A, MEYS NPU4NUDZ: LO1611; Czech Science Foundation, grant No. 16-13093S; Institutional Support 00023001IKEM.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Fenethylline (Captagon) abuse: Case report and literature review
Authors: Preve M. , Casigliani S. , Godio M. , Suardi N.E. , Traber R. , Colombo R.A. 
Published: June 2017

IntroductionNovel psychoactive drugs (NPS) has rapidly increase in the last years in the drug market as a recreational use. Fenethylline is a theophylline, an amphetamine-like drug, having stimulant effects similar to those of other amphetamine-type derivatives. Fenethylline was used as medicament for hyperactivity disorders in children, narcolepsy and depression, but it has also been used as a drug of abuse under the common name of ‘captagon’. The purpose of this report is to review the clinical evidence for the potential of abuse of fenethylline. We propose a case report and literature review.MethodWe conducted a systematic review of the literature with the principal database (PubMed, Enbase, PsychInfo) and we present a case report.ResultsThe effects of fenethylline is characterized by euphoria, derealization, autopsychic and somatopsychic depersonalization, hallucination, agitation and decrease of pain perception.Discussion and conclusionThe primary drug market for fenethyline (as captagon) has traditionally been countries located on the Arabian Peninsula but also North Africa since 2013. To our knowledge, there is no report on the recreational use of fenethylline in literature. The clinical features of fenethylline intoxication were also similar to effects from other amphetamine-like drugs. In our case report, dissociative symptoms are the core of fenethylline intoxication. Further research is warranted to replicate our clinical and qualitative observations and, in general, quantitative studies in large samples followed-up over time are needed. Methodological limitations, clinical implications and suggestions for future research directions are considered [1,2].Disclosure of interestThe authors have not supplied their declaration of competing interest.
Efficiency of Cocarnit preparation in clinical course of alcohol dependence at withdrawal syndrome stage
Authors: Sosin I. , Goncharova O. , Chuev Y. 
Published: June 2017

IntroductionRecently scientific attention of Ukrainian narcology was focused on the group of new complex pharmacological preparations with polymodal pathogenic effect option (Cocarnit, World Medicine, Great Britain).Aims and objectivesTo ground feasibility of Cocarnit application in complex treatment of alcohol withdrawal syndrome (AWS).MethodEleven patients with alcohol addiction were examined. An integrated research of relieving and adjuvant effects of pharmacological preparation Cocarnit in complex with traditional detoxication therapy in clinical course of alcohol dependence at AWS stage was carried out. One to 2 ampoules of Cocarnit were injected intramuscularly once per 24 hrs, № 6.MethodsClinical-psychopathological, clinical-laboratory, consulting of specialists, methods of psychological investigation (CIWA; САН; SF-36) at day 1, 7 and 14 of treatment.ResultsAWS quantification score on admission was 41. Further therapeutic regress of all AWS components was registered. At day 1 the patient's condition started improving, clinical score was 32; at day 3 – 17; day 5 – the score was 13, insignificant tremor remained. At day 7 of treatment, practically complete relieving effect of the therapy was ascertained. With САН method at day 7 of the treatment, an increase of figures in all scales was registered: state of health 2.7, activity 2.4, mood 2.5. SF-36 method: at day 1 – the score was 24, day 7 – 32, day 14 – 49.ConclusionsThus, the developed by us method of integrated treatment with inclusion of Cocarnit for withdrawal state in alcohol addicts allows to stop acute signs of pathology within 3–5 days.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Internet addiction and impulsivity among university students
Authors: Ünsalver B.Ö. , Aktepe H. 
Published: June 2017

IntroductionThe progress in technology adds to the new ways of communication between people. In our age, online communication has taken the place of face to face communication. People express themselves, become friends and in a way become who they are through the tools of social media. Many biological and psychological factors may affect the choice of people for communicating through social media.ObjectiveMain objective of this research is to measure the frequency of Internet addiction and it's relationship to social media use and impulsivity.MethodsThe population of the study is composed of 117 female (58.5%) and 83 male (41.5%) students between 18–25 years of age from Uskudar University. Barratt Impulsivity Scale and Internet Addiction Scale were used for data collection and measurement of variables.ResultsAmong the participants, 97.5% were found to go online everyday. Among the participants, 74.5% went online for social media use. Only 5% of the subjects fitted the criteria for Internet addiction. Thirty-six percent had limited symptoms for Internet addiction. Internet addiction symptoms and impulsivity were positively related. The tool for Internet access did not affect Internet addiction. Those who used a smart phone went online for social media use more commonly than those who used a computer.ConclusionIt has been debated that social media and the increase in smart phone use may be affecting young people and increase internet addiction rates, however we have found that impulsivity is an important factor for internet addiction as in other types of addiction.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Mental health profile of suicide victims in an Irish urban population
Authors: Udoh G. 
Published: June 2017

ObjectivesTo describe demographic and psychiatric characteristics of suicide victim cases.MethodRetrospective, case file psychological autopsy of deaths registered at the coroner's court, Dublin. Cases with a verdict of suicide and open verdicts registered in 2007, 2012 and 2013 were included.ResultsTwo hundred and five cases of suicide/open verdicts were registered the 3-year period. Seventy four percent (n = 152) were males. Mean age – 42.87 years old (STD = 15.44) with no significant difference between genders. Sixty-four percent (n = 132) were single at the time of death, while 32.2% had children. One hundred and ninety-eight had a stable accommodation; 37.5% (n = 77) living alone, and 36.6% (n = 75) actively employed.One hundred and twelve subjects (54.6%) suffered from mental illness; 53.6% – affective disorder; 15.2% – alcohol and substance misuse; 12.5% – psychotic disorder. Seventy-nine (70.5%) were not in contact with mental health services at the time of death; 32 (28.6%) were attending as outpatients. Illness onset was recorded for 68.7% cases (n = 77); 35.7% (n = 40) had a length of illness of more than 5 years. Psychiatric comorbidity was present in 29.5% (n = 33); 54.5% (n = 18) presented also alcohol/substance misuse.ConclusionSuicide victims were single, middle-aged male, suffered mental health difficulties, most frequently affective disorder. A small number of subjects an additional comorbid diagnosis. Few were in contact with outpatient services at the time of death. No significant differences in demographic characteristics were found between the group suffering from mental illness and the group with no mental illness.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Differential diagnostic of self-destructive behaviour via structural-dynamic model
Authors: Pyliagina G. 
Published: June 2017

ObjectivesStructural-dynamic model (SDM) of self-destructive behaviour (SdB) is needed for differential diagnostic of numerous features of SdB. SDM is based on an awareness that self-destructiveness has different variants with diversity of psychophysical damage as its outcome. SDM describes whole continuum of SdB variations and helps to differentiate them, to assess risk of suicidal or non-suicidal activity and to do long-term prognosis for SdB development as well.MethodsSDM of SdB is a generalized conception, which is a result of consequent scientific researches. The clinical criteria by ICD-10 and semi-structured suicidological interview were used in all of the surveys. In general, we observed 860 patients with suicidal attempt, suicidal ideas and self-destructive injuries.ResultsOur researches proved that SDM of SdB determine suicidological diagnosis implementing all-round assessment of SdB features of patient using kinds, forms and clinical-pathogenetic types as main categories of this concept. The kinds of SdB are: self-aggressive behaviour, self-destructive behaviour (it includes non-suicidal or psychotic variants) and suicidal behaviour. Each kind of SdB helps to detect pathogenetic mechanisms and dynamic tendencies in development of it. The form of SdB discloses behavioural specification in each case. There are equivalent, internal and external forms. The clinical-pathogenetic types of SdB are: suicidal, parasuicidal, pseudosuicidal or asuicidal. Each of them discloses significant clinical characteristics of actual self-destructive episode (nosology, syndrome, psychological traits, situation peculiarities, etc.). The differential diagnostic of SdB by SDM concept will allow doctors to treat patients more accurately and effectively.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Prenatal exposure to maternal depression and its influences on infant development and behaviour
Authors: Shakel N. , Shakel N. 
Published: June 2017

IntroductionDepression is one of the most common mental disorders worldwide. Women are more at risk of depression while they are pregnant, and during the first weeks and months of postpartum period. Perinatal depression, might influence the children‘s development during pregnancy as well as it can have negative affect and delay in child postnatal development.Materials and methodsPregnant women undergoing antenatal care in Latvia, Riga were interviewed using PHQ-9 and GAD-7 scales, the obtained data from the scale's results were analyzed and summarized in an analystic cross-sectional study. Literature overview.ResultsThere is a high correlation between the depressive episodes before pregnancy, during pregnancy and postpartum depression, as well as it have negative effects and delay in child postnatal development. Using Patient Health Questionnaire-9 and Generalised Anxiety Disorder Assessment-7 screening scales, was set up an inquiry among 200 pregnant women in Riga, Latvia. Depressive symptoms have 45% of pregnant women. 36% of pregnant women have mild depression symptoms, 3% moderate symptoms, 5% moderate serve symptoms and 1% serve depression symptoms. In its turn anxiety disorder screening results are following: 35% of pregnant women have mild anxiety symptoms, 9% moderate anxiety symptoms; 3% serve anxiety symptoms. Anxiety disorder symptoms note 47% of pregnant women. 36% of respondents note both depression symptoms and anxiety disorder symptoms.ConclusionHQ-9 and GAD-7 scales are informative, quick and easy for patients to complete. Children development and behavior has association with maternal depressive state during pregnancy. There is high prevalence of depression symptoms among preganant women in Latvia.Disclosure of interestThe authors have not supplied their declaration of competing interest.