bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant Nivolumab for Localized Renal Cell Carcinoma at High Risk of Recurrence After Nephrectomy: Part B of the Randomized, Placebo-Controlled, Phase III CheckMate 914 Trial
Authors: Motzer Robert J. , Bex Axel , Russo Paul , Tomita Yoshihiko , Cutuli Hernan Javier , Rojas Carlos , Gross-Goupil Marine , Schinzari Giovanni , Melichar Bohuslav , Barthélémy Philippe , Ruiz Garcia Abraham , Sosman Jeffrey , Grimm Marc-Oliver , Goh Jeffrey C. , Suarez Cristina , Kollmannsberger Christian K. , Nair Suresh G. , Shuch Brian M. , Huang Jian , Simsek Burcin , Spiridigliozzi Julia , Lee Chung-Wei , van Kooten Losio Maximiliano , Grünwald Viktor 
Published: September 2024

PURPOSE
CheckMate 914 is a two-part, randomized phase III trial evaluating adjuvant nivolumab plus ipilimumab (part A) or adjuvant nivolumab monotherapy (part B) versus placebo in mutually exclusive populations of patients with localized renal cell carcinoma (RCC) at high risk of postnephrectomy recurrence. Part A showed no disease-free survival (DFS) benefit for adjuvant nivolumab plus ipilimumab versus placebo. We report results from part B.

METHODS
Patients were randomly assigned (2:1:1) to nivolumab (240 mg once every 2 weeks for up to 12 doses), placebo, or nivolumab (240 mg once every 2 weeks for up to 12 doses) plus ipilimumab (1 mg/kg once every 6 weeks for up to four doses). The planned treatment duration was 24 weeks (approximately 5.5 months). The primary end point was DFS per blinded independent central review (BICR) for nivolumab versus placebo; safety was a secondary end point.

RESULTS

Overall, 825 patients were randomly assigned to nivolumab (n = 411), placebo (n = 208), or nivolumab plus ipilimumab (n = 206). With a median follow-up of 27.0 months (range, 18.0-42.4), the primary end point of improved DFS per BICR with nivolumab versus placebo was not met (hazard ratio [HR], 0.87 [95% CI, 0.62 to 1.21];
P
= .40); the median DFS was not reached in either arm, and 18-month DFS rates were 78.4% versus 75.4%. The HR for DFS per investigator was 0.80 (95% CI, 0.58 to 1.12;
P
= .19). Grade 3-4 all-cause adverse events (AEs) occurred in 17.2%, 15.0%, and 28.9% of patients with nivolumab, placebo, and nivolumab plus ipilimumab, respectively. Any-grade treatment-related AEs led to discontinuation in 9.6%, 1.0%, and 28.4%, respectively.

CONCLUSION
Part B of CheckMate 914 did not meet the primary end point of improved DFS for nivolumab versus placebo in patients with localized RCC at high risk of postnephrectomy recurrence.
The Rise of Informal Unions in the MENASA Region
Authors: Friedland Roger , Afary Janet 
Published: September 2024

Abstract
This article examines the nature of informal marriages using data from a 2018 survey of over ten thousand Facebook users in seven Muslim-majority countries: Algeria, Egypt, Iran, Pakistan, Palestine, Tunisia, and Turkey. The article explores current attitudes toward informal marriages as well as the nature of such unions among the predominantly Sunni and Shiʿi Muslim social-media users who took the survey. First, the article finds that informal marriages have diffused across the Sunni Muslim world. These marriages are not necessarily loveless unions between women of modest means looking for financial support and men seeking legitimate sexual partners. In fact, the survey suggests that women in such unions are less likely to be financially dependent on their partners. Informally married spouses are as likely to say that they love their partners as those who are formally wed. However, this love, whether in formal or informal marriages, does not necessarily entail a deep bond between partners who share their most intimate feelings. Marriage—whether formal or informal—is perceived as fragile, not a lifelong commitment. The rates of divorce in the countries surveyed are approaching those in the West. These informal marriages might therefore be thought of as a new form of cohabitation, a practice increasing throughout the world.
A microtubule stability switch alters isolated vascular smooth muscle Ca2+ flux in response to matrix rigidity
Authors: Johnson Robert T. , Wostear Finn , Solanki Reesha , Steward Oliver , Bradford Alice , Morris Christopher , Bidula Stefan , Warren Derek T. 
Published: September 2024

ABSTRACT
During ageing, the extracellular matrix of the aortic wall becomes more rigid. In response, vascular smooth muscle cells (VSMCs) generate enhanced contractile forces. Our previous findings demonstrate that VSMC volume is enhanced in response to increased matrix rigidity, but our understanding of the mechanisms regulating this process remain incomplete. In this study, we show that microtubule stability in VSMCs is reduced in response to enhanced matrix rigidity via Piezo1-mediated Ca2+ influx. Moreover, VSMC volume and Ca2+ flux is regulated by microtubule dynamics; microtubule-stabilising agents reduced both VSMC volume and Ca2+ flux on rigid hydrogels, whereas microtubule-destabilising agents increased VSMC volume and Ca2+ flux on pliable hydrogels. Finally, we show that disruption of the microtubule deacetylase HDAC6 uncoupled these processes and increased α-tubulin acetylation on K40, VSMC volume and Ca2+ flux on pliable hydrogels, but did not alter VSMC microtubule stability. These findings uncover a microtubule stability switch that controls VSMC volume by regulating Ca2+ flux. Taken together, these data demonstrate that manipulation of microtubule stability can modify VSMC response to matrix stiffness.
Skilled birth attendants' experiences of continuity for effective care coordination in Kenya: an interpretive phenomenology
Authors: Wainaina Grace Muira , Doreen Kaura , Jordan Portia 
Published: September 2024

Background/Aims Skilled birth attendants are vital in implementing and supporting maternal and neonatal care. Continuity of care enables coordination through the segments of the maternal and neonatal health continuum, from preconception to postpartum care. The aim of this study was to explore the experiences of skilled birth attendants in relation to providing continuity of care and effective coordination through the segments of the maternal and neonatal health continuum in Kenya. Methods An interpretive phenomenological approach was used in conducting 11 interviews with skilled birth attendants from four selected counties of Kenya using semi-structured guides. Interviews were carried out between June 2021 and January 2023. Participants were asked about their experiences of providing care during preconception, pregnancy, labour, birth and postpartum, as well as their perceptions of the health system in relation to providing continuity of care. Data were analysed using the van Manen approach. Results The themes were decisions during preconception care, enabling the antenatal journey, transitioning from pregnancy to birth and creating an enabled environment. Conclusions Skilled birth attendants highlighted the need for an enabled environment to provide appropriate care, emphasising the lack of understanding of the content in preconception care and lack of an appropriate site at the health facility to provide preconception care. Skilled birth attendants need an enabling environment in order to support women in each segment of the maternal and neonatal continuum and during transitions between segments. Implications for practice Skilled birth attendants' experiences should be considered when developing and reviewing guidelines for care across the maternal and neonatal health continuum. Skilled birth attendants need training and education on continuity and coordination of care.
New compact micro-hole zone catheter enables women to achieve effective bladder emptying without flow-stops
Authors: Thiruchelvam Nikesh , Hashim Hashim , Forman Christian Riis , Jacobsen Lotte , Sperup Trine , Andersen Karin 
Published: September 2024

Background: Clean intermittent self-catheterisation (CISC) with conventional eyelet catheters (CECs) is associated with urine flow-stops, which require the catheter to be repositioned so flow can resume. Flow-stops often occur because bladder mucosa is sucked into the eyelets. Aims: This investigation aimed to compare the bladder-emptying performance of the micro-hole zone catheter (MHZC) with the CEC. Methods: This was a multi-centre, randomised, open-label, controlled cross-over study with 82 women comparing the MHZC to the CEC. The endpoints relating to bladder-emptying performance included the residual volume at first flow-stop, the number of flow-stops and the proportion of successful treatment responses. The women's perception of the catheters was assessed as well as device discomfort. Findings: Catheterisations with MHZC significantly reduced the risk of flow-stops, with relative risk results showing a 2.74 times lower risk of flow-stops with a health professional-led catheterisation and a 2.52 times lower risk during self-catheterisation. There was no statistical difference in residual urine volume at first flow-stop between the two catheters. Catheterisations with the MHZC were significantly more likely to achieve zero flow-stops and a residual urine volume of <10 ml at first flow-stop. The women had a significantly more positive perception of the MHZC than the CEC in areas including handling, confidence, sensation and satisfaction. Conclusion: The MHZC enabled effective bladder emptying without catheters needing to be repositioned, supporting the women by simplifying the procedure and making them feel confident that their bladders were empty.
The gap between expectations and reality in advance care planning in long-term care settings
Authors: Tam Kuai In , Che Sok Leng , Leong Sok Man , Lau Wing Sze 
Published: September 2024

Background: Advance care planning (ACP) is an integral part of good quality end-of-life care. This study aimed to explore the role and practice of ACP among health and social care professionals (HSCPs) in a community long-term care facility. Methods: This was a mixed-methods study. The study purposefully sampled 12 HSCPs from one community long-term care facility in Macao, China. All data were collected in November 2022. Results: Some participants had discussed with terminally ill residents or with families in terms of end-of-life care preferences, the average correct rate of ACP knowledge was 67.4%. Interview data showed that HSCPs were primarily concerned with information-giving. The responsibility of decision-making was found to have been placed predominantly on family members of the residents. Conclusion: Study findings raised awareness in that the execution of ACP has remained in discord with the expectations in practicing ACP. The study illuminated that the perceived sense of responsibility among HSCPs was influenced by the potential legal risks involved and consequentially impacted on the adherence to individual's decisions.
Consumer Willingness-to-Pay a Price Premium for Eco-Friendly Children's Furniture in Shanghai and Shenzhen, China
Authors: Wan Minli , Zhang Yijing , Ye Weihua 
Published: September 2024

Abstract
The sustained and rapid growth of China's economy has led to the improvement of Chinese living standards. This, in turn, has led to the adoption of the lifestyles of health and sustainability (LOHAS) by many Chinese middle-class consumers. In pursuit of a higher quality of life, these consumers have shown a growing interest in eco-friendly products, including eco-friendly children's furniture. Using a structured questionnaire distributed to a sample of 320 consumers in two Chinese metropolitan cities (Shanghai and Shenzhen) in 2013, this study examined consumer stated willingness-to-pay (WTP) a price premium for eco-friendly children's furniture. Results indicate that 98 percent of respondents would be willing to pay a premium for such products. Of these respondents, 53 percent of them stated a WTP of no greater than 10 percent, while 45 percent of them stated a WTP of more than 10 percent. Results of an ordered probit model suggest significant correlations between respondent WTP and their marital status, education level, LOHAS orientation, and environmental perceptions. The findings of this study can serve as a useful reference for policy makers, furniture producers, and wood material suppliers that are currently planning to enter eco-friendly markets where price premiums might exist.
Modeling International Trade of Forest Products: Application of PPML to a Gravity Model of Trade
Authors: Larson Justin , Baker Justin , Latta Gregory , Ohrel Sara , Wade Christopher 
Published: September 2024

Abstract
To model international trade of forest products we use a gravity model of trade. In modeling trade, we estimate the impact of importer gross domestic product (GDP), exporter GDP, and distance between trading partners using Poisson pseudo-maximum likelihood (PPML). When estimating the log-linearized gravity model (ordinary least squares [OLS]), two issues arise. First, potential bias associated with truncation of all zero-trade observations due to the nonexistence of the natural log of zero. Second, heteroscedasticity can bias results from the log-linearized gravity model because of the multiplicative error term of the stochastic gravity model. To address these two issues, we propose avoiding the log-linearized gravity model and instead estimate the nonlinear gravity model via PPML. To estimate the model, trade data are compiled from the Food and Agriculture Organization of the United Nations. The observation window is from 1997 to 2014 and covers 13 product categories at a country-pair level. In our estimation, we find systematic differences in estimates from OLS in comparison with estimates from PPML. Using the estimated elasticities, in combination with estimates of future GDP from shared socioeconomic pathways, we project future US exports to the year 2030 for each item category in addition to total exports for Brazilian wood pulp, New Zealand industrial roundwood, and Canadian coniferous sawnwood. Using our approach, we provide a tool for policy makers and industry leaders alike to make informed decisions over prior estimates of forest product trade.
Cost–Benefit Analysis of Medium-Density Fiberboard Production by Adding Fiber from Recycled Medium-Density Fiberboard
Authors: Adeeb Ehsan , Kim Tae Woo , Sohn Chang Hyun 
Published: September 2024

Abstract
Waste medium-density fiberboard (MDF) is mostly disposed of in landfills and left for incineration. The consequences of filling MDF waste to the landfill include undesirable associated costs and environmental problems caused by incineration. In this study, a prediction method is used for calculating the thermal energy required to recycle MDF fibers. The recycling method consists of a high-temperature treatment in a preheater at an operating temperature of 100°C, which melts the resin and separates the fibers. The cost reduction and energy savings of virgin wood material are calculated for MDF that has been manufactured by replacing 10 and 20 percent of the wood fiber with recycled fiber. Results show that the benefits of MDF production using 10 percent recycled fiber result in a 10 percent reduction in virgin wood material costs and an energy savings of 3.9 percent. Using 20 percent recycled fiber results in an estimated 20 percent reduction in the cost of virgin wood material and an energy savings of 7.8 percent for MDF production. The predicted amounts of thermal energy required to produce MDF are consistent with those of previous studies.
Modification of Wood Flour/Phenolic Resin Composites with Bamboo Pulp Residue
Authors: Hao Chengyi , Zhang Kaiqiang , Zhang Shuangbao , Song Wei 
Published: September 2024

Abstract
The purpose of this paper is to discuss the influence of different proportions of bamboo pulp residue on the bending strength, the static bending strength, the water absorption rate, and the microstructure of wood flour/phenolic resin composites. The level of bamboo pulp residue ranged from 0 to 30 percent. According to the optimum technological parameters of the pretest, the resin content, the molding temperature, and the molding time were controlled within 51 to 54 percent, 152°C to 160°C, and 51 to 60 s/mm, respectively. Compared with the control group, there were remarkable improvements in the mechanical properties, indicating that the bending strength, the static bending strength, and the water absorption rate increased by 39, 31, and −6 percent, respectively. The greatest level of bamboo pulp residue was 20, 20, and 10 percent for the bending strength, the static bending strength, and the water absorption rate, respectively. All of the above proved that the wood flour/phenolic resin composites can be modified by adding bamboo pulp residue.
Characterization of Odorants in Particleboard Coated with Nitrocellulose Lacquer under Different Environment Conditions
Authors: Wang Qifan , Shen Jun , Du Jianhui , Cao Tianyu , Xiwei Shen 
Published: September 2024

Abstract
It is well known that the release of volatile organic compounds (VOCs) and odors from wood-based panels is harmful to human health. The VOCs emitted from decorative wood-based panels have been investigated generally, but information is limited regarding the key odor compounds that people find most irritating. In this experiment, particleboard coated with nitrocellulose lacquer was analyzed by gas chromatography coupled with mass spectrometry and olfactometry. Twenty odors were identified, which arose between 5 and 25 minutes. Most odorants from nitrocellulose lacquer–coated particleboard were aromatics, esters, and alcohols, whereas those from control (unvarnished) particleboard were aromatics, aldehydes, and esters. With an increasing ratio of air exchange rate to loading factor, the total VOCs concentration and the total value of odor intensity from nitrocellulose lacquer–coated particleboard declined. However, both increased as temperature and relative humidity rose. The fluctuation of total VOCs between different days tended to fluctuate more sharply when the temperature and relative humidity rose and when the ratio of air exchange rate to loading factor dropped. To accelerate the release of VOCs and odors and reduce their effects on humans, the optimum storing conditions for particleboard with a nitrocellulose lacquer after-production were 40°C, 60 percent relative humidity, and a 1.0-m3·h−1·m−2 ratio of air exchange rate to loading factor.
Performance of an Encapsulated Chloropicrin System for Remedial Treatment of Utility Poles
Authors: Konkler Matthew , Helsing Guy G. , Morrell Jeffrey J. 
Published: September 2024

Abstract
Chloropicrin remains one of the most effective fumigants for arresting internal decay in large timber structures, but it can be difficult to handle. The potential for encapsulating chloropicrin to improve application safety and control the release rate was investigated in Douglas-fir poles. A quick-release ampule resulted in chloropicrin levels that were similar to those found with a similar amount of liquid chloropicrin, whereas moderate- and slow-release ampules resulted in proportionally less chloropicrin in the wood over a 4-year period, but levels were still well above the protective threshold. The results suggest that encapsulated chloropicrin improved handling safety without reducing performance. Further monitoring is planned.
Profiles of diphtheria cases in children in Hasan Sadikin Hospital, West Java
Authors: Iskandar Safira Atya , Setiabudi Djatnika , Tarigan Rodman , Alam Anggraini , Afriandi Irvan 
Published: September 2024

Background Diphtheria cases continue to be reported in Indonesia, which has long been one of the countries with the highest number of diphtheria cases worldwide. One of Indonesia's province with the highest annual diphtheria cases is West Java. Dr. Hasan Sadikin General Hospital (RSHS) is one of the tertiary referral hospitals in Bandung, West Java, that treats several diphtheria cases annually. No study focused on the clinical characteristics of diphtheria cases in children admitted to RSHS between 2017 and 2021 yet. Therefore, this study sought to analyze that.
Objective To find out the profiles of children < 18-year-old with diphtheria admitted in RSHS between 2017-2021.
Methods This descriptive, cross-sectional study reviewed the medical records of diphtheria patients 0 to 18-year-old who were admitted to RSHS between year 2017 and 2021.
Results Out of 45 subjects, 76% were males. The median of age was eight years old, ranging from 2 to 17 years. Most patients lived in urban areas and had normal anthropometry status, although some showed abnormal findings. The data showed that 44% had more than 3 days of onset until admission to the hospital, and the median length of stay was 9 days. The clinical characteristics showed that 91% of patients had pseudomembrane, also present with cough, common cold, hoarseness, stridor, and bull’s neck. As many as 44% of patients did not have complete basic immunization status. Complications found were airway obstructions, myocarditis, and sepsis, and 2 deaths were reported.
Conclusion Pseudomembrane was found in the majority of patients. Most patients were over five years of age, and almost half number of the patients did not have complete basic immunization status, indicating the need for improved immunization and booster coverage.
Das ungarische Bibliothekssystem und die Veränderungen der Situation der Bibliothekare nach 1990
Authors: Monok István 
Published: September 2024

Zusammenfassung
Die Basis des ungarischen Bibliothekssystems wurde in der Zeit vor der politischen und wirtschaftlichen Wende um 1990 gelegt. In den 1990er-Jahren bildete dies die Grundlage für eine dynamische Ausweitung internationaler Kontakte, unterstützt durch die Offenheit Westeuropas. Die wirtschaftlichen Veränderungen und die gesellschaftlichen Umwälzungen in Ungarn werteten jedoch die Bibliotheken, die Bibliothekare und das in Büchern gespeicherte Wissen ab. Es entwickelte sich die Idee, dass die IT-Welt und ihre Unternehmen Bibliotheken ersetzen könnten. Sie bieten Dienste an, aber sie dienen ihnen nicht.
Die ungarischen Bibliotheken versuchen, die Möglichkeiten der Informationstechnologie zu nutzen, indem sie ihre eigenen kontrollierten Datenbestände valorisieren und eine neue soziale Rolle übernehmen. Ihr Erfolg wird jedoch durch den Abbau von Personal, unzureichende Budgets und internationale Isolierung beeinträchtigt.