bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progression of late postoperative atrial fibrillation in patients with tetralogy of Fallot
Authors: Ramdjan Tanwier T.T.K. , Mouws Elisabeth M.J.P. , Teuwen Christophe P. , Sitorus Gustaf D.S. , Houck Charlotte A. , Bogers Ad J.J.C. , de Groot Natasja M.S. 
Published: October 2017

AbstractIntroductionToF patients are at risk for ventricular deterioration at a relatively young age, which can be aggravated by AF development. Therefore, knowledge on AF development and its timespan of progression is essential to guide treatment strategies for AF.ObjectiveWe examined late postoperative AF onset and progression in ToF patients during long‐term follow‐up after ToF correction. In addition, coexistence of AF with regular supraventricular tachyarrhythmias (SVT) and ventricular tachyarrhythmias (VTA) was analyzed.Methods and resultsToF patients (N = 29) with AF after ToF correction referred to the electrophysiology department between 2000 and 2015 were included. All available rhythm registrations were reviewed for AF, regular SVT, and VTA. AF progression was defined as transition from paroxysmal AF to (longstanding) persistent/permanent AF or from (longstanding) persistent AF to permanent AF. At the age of 44 ± 12 years, ToF patients presented with paroxysmal (N = 14, 48%), persistent (N = 13, 45%) or permanent AF (N = 2, 7%). Age of AF development was similar among patients who either underwent initial shunt creation (N = 15, 45 ± 11 [25–57] years) or primary total ToF correction (N = 14, 43 ± 13 [26–66] years) (P = 0.785). AF coexisted with regular SVT (N = 18, 62%) and VTA (N = 13, 45%). Progression of AF occurred in 11 patients (38%) within 5 ± 5 years after AF onset despite antiarrhythmic drug class II (AAD, P = 0.052) or III (P = 0.587) usage.ConclusionsAF in our ToF population developed at a young age and showed rapid progression. Rhythm control by pharmacological therapy was ineffective in preventing AF progression.
The drivers of sea lice management policies and how best to integrate them into a risk management strategy: An ecosystem approach to sea lice management
Authors: Jackson D , Moberg O , Stenevik Djupevåg E M , Kane F , Hareide H 
Published: October 2017

AbstractThe control of sea lice infestations on cultivated Atlantic salmon is a major issue in many regions of the world. The numerous drivers which shape the priorities and objectives of the control strategies vary for different regions/jurisdictions. These range from the animal welfare and economic priorities of the producers, to the mitigation of any potential impacts on wild stocks. Veterinary ethics, environmental impacts of therapeutants, and impacts for organic certification of the produce are, amongst others, additional sets of factors which should be considered. Current best practice in both EU and international environmental law advocates a holistic ecosystem approach to assessment of impacts and risks. The issues of biosecurity and ethics, including the impacts on the stocks of species used as cleaner fish, are areas for inclusion in such a holistic ecosystem assessment. The Drivers, Pressures, State, Impacts, Responses (DPSIR) process is examined as a decision‐making framework and potential applications to sea lice management are outlined. It is argued that this is required to underpin any integrated sea lice management (ISLM) strategy to balance pressures and outcomes and ensure a holistic approach to managing the issue of sea lice infestations on farmed stock on a medium to long‐term basis.
Factors associated with ambulatory care sensitive emergency department visits for South Carolina Medicaid members with intellectual disability
Authors: McDermott S. , Royer J. , Mann J. R. , Armour B. S. 
Published: October 2017

AbstractIntroductionAmbulatory care sensitive conditions (ACSCs) can be seen as failure of access or management in primary care settings. Identifying factors associated with ACSCs for individuals with an Intellectual Disability (ID) provide insight into potential interventions.MethodTo assess the association between emergency department (ED) ACSC visits and a number of demographic and health characteristics of South Carolina Medicaid members with ID.A retrospective cohort of adults with ID was followed from 2001 to 2011. Using ICD‐9‐CM codes, four ID subgroups, totalling 14 650 members, were studied.ResultsThere were 106 919 ED visits, with 21 214 visits (19.8%) classified as ACSC. Of those, 82.9% were treated and released from EDs with costs averaging $578 per visit. People with mild and unspecified ID averaged greater than one ED visit per member year. Those with Down syndrome and other genetic cause ID had the lowest rates of ED visits but the highest percentage of ACSC ED visits that resulted in inpatient hospitalisation (26.6% vs. an average of 16.8% for other subgroups). When compared with other residential types, those residing at home with no health support services had the highest ED visit rate and were most likely to be discharged back to the community following an ED visit (85.2%). Adults residing in a nursing home had lower rates of ED visits but were most likely to be admitted to the hospital (38.9%) following an ED visit. Epilepsy and convulsions were the leading cause (29.6%) of ACSC ED visits across all subgroups and residential settings.ConclusionPrevention of ACSC ED visits may be possible by targeting adults with ID who live at home without health support services.
Increased maternal insulin resistance promotes placental growth and decreases placental efficiency in pregnancies with obesity and gestational diabetes mellitus
Authors: Tanaka Kei , Yamada Kenji , Matsushima Miho , Izawa Tomoko , Furukawa Seishi , Kobayashi Yoichi , Iwashita Mitsutoshi 
Published: October 2017

AbstractAim
Homeostasis model assessment for insulin resistance (HOMA‐IR) was measured during pregnancy to analyze placental weight and efficiency in relation to maternal insulin resistance.MethodsA retrospective study of 510 pregnant women (130 with gestational diabetes mellitus [GDM], 380 with normal glucose tolerance) was conducted. We reviewed the patients’ demographic data (age, parity, pre‐pregnancy body mass index [BMI]) and perinatal outcomes (birth weight, placental weight, BMI at delivery, maternal weight gain, HOMA‐IR). The birth weight to placental weight (B/P) ratio was calculated for placental efficiency. The subjects were categorized by BMI at delivery, and maternal, neonatal and placental characteristics were compared between the groups to investigate the determinants of placental weight and B/P ratios.ResultsObesity was significantly associated with heavier placental weight and lower B/P ratios. The presence of GDM did not affect placental weight, whereas the B/P ratios in women with GDM were significantly lower than in women with normal glucose tolerance. HOMA‐IR was positively correlated with placental weight (ρ = 0.217, P < 0.001) and negatively with B/P ratio (ρ = −0.181, P < 0.001).ConclusionsIncreased maternal insulin resistance promoted placental growth and inhibited placental efficiency. Maternal insulin resistance may be one of the pathophysiological conditions responsible for altered placental size and function in pregnancies with obesity and GDM.
Cost effectiveness analysis of carbetocin during cesarean section in a high volume maternity unit
Authors: Voon Hian Yan , Shafie Asrul A. , Bujang Mohamad A. , Suharjono Haris N. 
Published: October 2017

AbstractAimTo evaluate the cost effectiveness of carbetocin compared to oxytocin when used as prophylaxis against post‐partum hemorrhage (PPH) during cesarean deliveries.MethodsA systematic review of the literature was performed to identify randomized controlled trials that compared the use of carbetocin to oxytocin in the context of cesarean deliveries. Cost effectiveness analysis was then performed using secondary data from the perspective of a maternity unit within the Malaysian Ministry of Health, over a 24 h time period.ResultsSeven randomized controlled trials with over 2000 patients comparing carbetocin with oxytocin during cesarean section were identified. The use of carbetocin in our center, which has an average of 3000 cesarean deliveries annually, would have prevented 108 episodes of PPH, 104 episodes of transfusion and reduced the need for additional uterotonics in 455 patients. The incremental cost effectiveness ratio of carbetocin for averting an episode of PPH was US$278.70.ConclusionReduction in retreatment, staffing requirements, transfusion and potential medication errors mitigates the higher index cost of carbetocin. From a pharmacoeconomic perspective, in the context of cesarean section, carbetocin was cost effective as prophylaxis against PPH. Ultimately, the relative value placed on the outcomes above and the individual unit's resources would influence the choice of uterotonic.
Effect of Royal Jelly on behavioural patterns, feather quality, egg quality and some haematological parameters in laying hens at the late stage of production
Authors: El‐Tarabany M. S. 
Published: October 2017

SummaryThe aim was to elucidate the impact of Royal Jelly (RJ) on behavioural patterns, feather cover, egg quality and some blood haematological indices in laying hens (58–64 weeks of age). A total of 108 Tetra Brown laying hens were used in the current trial. The birds were divided into three equal groups (36 birds each). The pure RJ was prepared for immediate injection subcutaneously, as follows: the first treated group (RJ1:100 mg/kg); the second treated group (RJ2:200 mg/kg); the control group. The eating and drinking activities in the RJ2 group were significantly (p = .009 and .015 respectively) higher than the control and RJ1 groups. Furthermore, the aggressive pecks, feather pecks and threating behaviour in the RJ2 group were significantly (p = .005, .001 and .039 respectively) lower than the control and RJ1 groups. Both RJ‐treated groups had the best feather cover on the neck and abdomen regions (p = .010 and .001 respectively; Figure ). Both RJ‐treated groups had a significantly higher eggshell ratio (p = .019) and shell thickness (p = .001) in comparison with the control group. The albumen height, Haugh units and yolk index in both RJ‐treated groups were significantly greater than those recorded in the control group (p = .026, .001 and .022 respectively). The erythrocyte and total leucocyte counts in the RJ2 group were significantly higher than those reported in the control and RJ1 groups (p = .029 and .013 respectively); however, the heterophil/lymphocyte (H/L) ratio and heterophil % in both RJ‐treated groups were significantly the lowest (p = .001 and .039). In conclusion, birds in the RJ2 group had superior feather cover, welfare and behavioural indices, probably due to the impact of active flavonoids components of RJ on laying hen performance. Furthermore, the RJ‐treated groups had significantly improved egg quality parameters and some blood haematological indices.
Buffalo heifers selected for lower residual feed intake have lower feed intake, better dietary nitrogen utilisation and reduced enteric methane production
Authors: Sharma V. K. , Kundu S. S. , Datt C. , Prusty S. , Kumar M. , Sontakke U. B. 
Published: October 2017

SummaryThis study was conducted to evaluate the utilisation of the residual feed intake (RFI) as a feed efficiency selection tool and its relationship with methane emissions. Eighteen Murrah buffalo (Bubalus bubalis) heifers were fed ad libitum with total mixed ration (TMR) for 120 days. Based on linear regression models involving dry matter intake (DMI), average daily gain (ADG) and mid‐test metabolic body size (MBW0.75), heifers were assigned into low and high RFI groups. The RFI varied from −0.09 to +0.12 kg DM/day with average RFI of −0.05 and 0.05 kg DM/day in low and high RFI heifers respectively. Low RFI heifers ate 11.6% less DM each day, yet average daily gain (ADG) and feed utilisation were comparable among low and high RFI groups. Low RFI heifers required significantly (p < .05) less metabolizable energy for maintenance (MEm) compared to high RFI heifers. Apparent nutrient digestibility showed non‐significant difference (p > .05) among low and high RFI groups. Although the nitrogen balance was similar among heifers of low and high RFI groups, nitrogen metabolism was significantly higher (p > .05) in high RFI heifers. Comparison of data from heifers exhibiting the low (n = 9) and high (n = 9) RFI showed that the low RFI heifers have lower enteric methane production and methane losses than high RFI heifers. In conclusion, results of this study revealed that selection of more efficient buffalo heifers has multiple benefits, such as decreased feed intake and less emission of methane.
Glioplasticity in irritable bowel syndrome
Authors: Lilli N. L. , Quénéhervé L. , Haddara S. , Brochard C. , Aubert P. , Rolli‐Derkinderen M. , Durand T. , Naveilhan P. , Hardouin J.‐B. , De Giorgio R. , Barbara G. , Bruley des Varannes S. , Coron E. , Neunlist M. 
Published: October 2017

AbstractBackgroundGrowing evidence indicates a wide array of cellular remodeling in the mucosal microenvironment during irritable bowel syndrome (IBS), which possibly contributes to pathophysiology and symptom generation. Here, we investigated whether enteric glial cells (EGC) may be altered, and which factors/mechanisms lead to these changes.MethodsColonic mucosal biopsies of IBS patients (13 IBS‐Constipation [IBS‐C]; 10 IBS‐Diarrhea [IBS‐D]; 11 IBS‐Mixed [IBS‐M]) and 24 healthy controls (HC) were analyzed. Expression of S100β and GFAP was measured. Cultured rat EGC were incubated with supernatants from mucosal biopsies, then proliferation and Ca2+ response to ATP were analyzed using flow cytometry and Ca2+ imaging. Histamine and histamine 1‐receptor (H1R) involvement in the effects of supernatant upon EGC was analyzed.Key ResultsCompared to HC, the mucosal area immunoreactive for S100β was significantly reduced in biopsies of IBS patients, independently of the IBS subtype. IBS‐C supernatants reduced EGC proliferation and IBS‐D and IBS‐M supernatants reduced Ca2+ response to ATP in EGC. EGC expressed H1R and the effects of supernatant upon Ca2+ response to ATP in EGC were blocked by pyrilamine and reproduced by histamine via H1R. IBS supernatants reduced mRNA expression of connexin‐43. The S100β‐stained area was negatively correlated with the frequency and intensity of pain and bloating.Conclusion and InferencesChanges in EGC occur in IBS, involving mucosal soluble factors. Histamine, via activation of H1R‐dependent pathways, partly mediates altered Ca2+ response to ATP in EGC. These changes may contribute to the pathophysiology and the perception of pain and bloating in patients with IBS.
Complexity of intravenous iron nanoparticle formulations: implications for bioequivalence evaluation
Authors: Pai Amy Barton 
Published: October 2017

AbstractIntravenous iron formulations are a class of complex drugs that are commonly used to treat a wide variety of disease states associated with iron deficiency and anemia. Venofer® (iron–sucrose) is one of the most frequently used formulations, with more than 90% of dialysis patients in the United States receiving this formulation. Emerging data from global markets outside the United States, where many iron–sucrose similars or copies are available, have shown that these formulations may have safety and efficacy profiles that differ from the reference listed drug. This may be attributable to uncharacterized differences in physicochemical characteristics and/or differences in labile iron release. As bioequivalence evaluation guidance evolves, clinicians should be educated on these potential clinical issues before a switch to the generic formulation is made in the clinical setting.
Alleles on the two dwarfing loci on 4B and 4D are main drivers of FHB‐related traits in the Canadian winter wheat population “Vienna” × “25R47”
Authors: Tamburic‐Ilincic Ljiljana , Barcellos Rosa Silvia 
Published: October 2017

AbstractFusarium head blight (FHB), leaf rust and stem rust are among the most destructive wheat diseases. High‐yielding, native disease resistance sources are available in North America. The objective of this study was to map loci associated with FHB traits, leaf rust, stem rust and plant height in a “Vienna”/”25R47” population. DArT markers were used to generate a genetic map, and quantitative trait loci (QTL) analysis was performed by evaluating 113 doubled haploid lines across three environments in Ontario, Canada. FHB resistance QTL were identified on chromosomes 4D, 4B, 2D and 7A, while a QTL for leaf and stem rust resistance was identified on chromosome 1B. The dwarfing alleles of both Rht‐B1 and Rht‐D1 were associated with increased FHB index and DON content.
Emotion regulation dimensions and relationship satisfaction in clinical couples
Authors: RICK JENNIFER L. , FALCONIER MARIANA K. , WITTENBORN ANDREA K. 
Published: October 2017

AbstractThe present study explored the relation between the multidimensional construct of emotion regulation and relationship satisfaction in 104 couples seeking couple or family therapy. Satisfaction was assessed via the Dyadic Satisfaction Subscale of the Dyadic Adjustment Scale, whereas the Difficulties in Emotion Regulation Scale was used to assess the 6 dimensions of emotion regulation (acceptance, goals, impulse, awareness, strategies, clarity). Significant relations were found between relationship satisfaction and acceptance, impulse, awareness, and strategies. Relations were not always found in expected directions, and although actor effects were found for both genders, only women displayed partner effects. Findings point to the importance of considering context when studying emotion regulation and highlight the clinical importance of evaluating its specific dimensions.
Early predictors of mortality in children with pulmonary complications after haematopoietic stem cell transplantation
Authors: Choi Yu Hyeon , Jeong Hyung Joo , An Hong Yul , Kim You Sun , Lee Eui Jun , Lee Bongjin , Kang Hyoung Jin , Shin Hee Young , Park June Dong 
Published: October 2017

AbstractPC are a main cause of death following HSCT in children. We aimed to evaluate early predictors of mortality in paediatric recipients with PCs. A retrospective observational study of 35 patients with 49 episodes of PI on chest radiography (of 124 patients) who had undergone HSCT at a tertiary university hospital between January 2011 and December 2012 was performed. During follow‐up (median 26.1 months), 15 episodes led to death (30.6%). An aetiologic diagnosis was made by non‐invasive tests in 24 episodes (49.0%) and by adding bronchoalveolar lavage and/or lung biopsy in 7 episodes with diagnostic yield (77.8%, P = .001). Thus, a specific diagnosis was obtained in 63.3% of the episodes. Aetiology identification and treatment modification after diagnosis did not decrease mortality (P = .057, P = .481). However, the number of organ dysfunctions at the beginning of PI was higher in the mortality group, compared to the survivor group (1.7 ± 1.2 vs 0.32 ± 0.59; P = .001). Hepatic dysfunction (OR, 11.145; 95% CI, 1.23 to 101.29; P = .032) and neutropaenia (OR, 10.558; 95% CI, 1.07 to 104.65; P = .044) were independently associated with risk of mortality. Therefore, hepatic dysfunction and neutropaenia are independent early predictors of mortality in HSCT recipients with PCs.
International trade and the division of labor
Authors: Soo Kwok Tong 
Published: October 2017

AbstractThis paper develops a model of international trade based on the division of labor under perfect competition. International trade, by eliminating the duplication of coordination costs, leads to a greater variety of tasks, each produced at a larger scale than in autarky. The greater variety of tasks implies greater division of labor and hence gains from trade. Extending the model to two factors of production yields the additional result that if the two countries are sufficiently similar in their relative endowments, then both factors of production can experience gains from trade.
Democracy, Geography and Model Uncertainty
Authors: Oberdabernig Doris A. , Humer Stefan , Crespo Cuaresma Jesus 
Published: October 2017

AbstractWe analyse the nature of robust determinants of differences in democracy levels across countries taking explicitly into account uncertainty in the choice of covariates and spatial spillovers. We make use of recent developments in Bayesian model averaging to assess the effect of a large number of potential factors affecting democratisation processes and account for several specifications of spatial linkages. Our results indicate that spatial spillovers are present in the data even after controlling for a large number of geographical covariates. Addressing the determinants of democracy without modelling such spillovers may lead to flawed inference about the nature of the determinants of democratisation processes. In particular, our results emphasise the role played by Muslim religion, population size, trade volumes, English language, natural resource rents, GDP per capita, being a MENA country and the incidence of armed conflicts as factors affecting democracy robustly.
Characteristics of Quality Improvement Champions in Nursing Homes: A Systematic Review With Implications for Evidence‐Based Practice
Authors: Woo Kyungmi , Milworm Gvira , Dowding Dawn 
Published: October 2017

ABSTRACTBackgroundImproving care quality while reducing cost has always been a focus of nursing homes. Certified nursing assistants comprise the largest proportion of the workforce in nursing homes and have the potential to contribute to the quality of care provided. Quality improvement (QI) initiatives using certified nursing assistants as champions have the potential to improve job satisfaction, which has been associated with care quality.AimsTo identify the role, use and preparation of champions in a nursing home setting as a way of informing future QI strategies in nursing homes.MethodsA systematic literature review. Medical Subject Headings and text words for “quality improvement” were combined with those for “champion*” to search Medline, CINAHL, Joanna Briggs Institute, MedLine In‐Process, and other Nonindexed Citations. After duplicates were removed, a total of 337 potential articles were identified for further review. After full text review, seven articles from five original studies met inclusion criteria and were included in the synthesis.ResultsVarious types of QI initiatives and implementation strategies were used together with champions. Champions were identified by study authors as one of the single most effective strategies employed in all studies. The majority of studies described the champion role as that of a leader, who fosters and reinforces changes for improvement. Although all the included studies suggested that implementing nurse or aid champions in their QI initiatives were important facilitators of success, how the champions were selected and trained in their role is either missing or not described in any detail in the studies included in the review.Linking Evidence to ActionUtilizing certified nursing assistants as QI champions can increase participation in QI projects and has the potential to improve job satisfaction and contribute to improve quality of care and improved patient outcomes in nursing homes.
Older hospitalized patients’ experiences of dialogue with healthcare providers in hospitals: a systematic review protocol
Authors: Nielsen Gitte , Larsen Karen Lyng , Uhrenfeldt Lisbeth 
Published: October 2017

Review question/objective:
: The objective is to identify and synthesize findings from qualitative studies of older (over 65 years) hospitalized patients’ experiences of the barriers and facilitators to their dialogues with healthcare providers (HCPs) concerning their health and well-being.
Specifically, the review questions are:1. How do older patients in hospitals describe their experiences of dialogues with HCPs?2. What are the barriers and facilitators to older patients’ dialogues with HCPs regarding their health and well-being?