bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Angiotensin‐converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the susceptibility to psoriasis and oxidative stress (OS) in a cohort of pediatric psoriatic patients in Sri Lanka: A cross sectional study
Authors: Udayanga S. A. K. , Seneviratne J. , Saumyamala M. G. A. , Amarasekara A. D. D. S. 
Published: September 2024

AbstractBackgroundPediatric psoriasis accounts for nearly one‐third of the global psoriasis burden. Multiple lines of evidence have shown the relationship between Angiotensin‐converting enzyme (ACE) Insertion (I)/deletion(D) polymorphism with psoriasis susceptibility, and oxidative stress (OS) in psoriatic patients. However, such studies, particularly on pediatric psoriasis, are scarce in the local setting.AimsOur study investigated the prevalence of ACE I/D polymorphism and its associations with oxidative stress in pediatric psoriasis patients in Sri Lanka.MethodsThirty patients were recruited for this study after obtaining ethical clearance. The polymerase chain reaction was used to explore the ACE I/D polymorphism. Serum Nitric Oxide (NO) levels and the Total Antioxidant Capacity (TAC) were measured using the Griess assay and the FRAP assay. Clinical details were obtained from the clinic reports.ResultsFemale predominance (76.67%) in pediatric psoriasis was reported, while Plaque psoriasis (66.67%) was found to be the most prevalent form. I/D was reported as the predominant genotype (66.67%) while I/I and D/D genotypes were recorded in 23.33% and 10% of patients, respectively. Significantly higher NO levels were observed in I/D patients than in I/I patients but not among other groups. No differences in TAC among ACE genotypes were reported.ConclusionThis pilot study revealed female gender and I/D genotype with increased NO levels as risk factors for pediatric psoriasis in Sri Lanka. However, it is prudent to increase the sample size to further validate the results.
Preventive care for individuals with deep pressure ulcers in Sweden living at home: A cross‐sectional study
Authors: Bååth Carina , Carlsson Annika , Larsson Bodil Wilde , Sving Eva 
Published: September 2024

AbstractBackground and AimsSeveral factors exist regarding the risk for, healing and prevention of pressure ulcers (PUs). A mobile PU team with an individualized holistic approach adapted to the home or outpatient clinic setting could be beneficial for the prevention, and management of PUs.AimsTo describe the mobile PU team's interventions among individuals who had deep PUs and were living at home. Another aim was to describe the patients' perceptions of the quality of the care and having a deep PU.MethodsA quantitative study with a cross‐sectional design. At an outpatient clinic, a mobile PU team was established to perform and follow up PU prevention interventions and advanced wound care treatment at home and at the outpatient clinic. All adult patients with existing deep category four PUs remitted to the outpatient clinic were asked to participate, and 16 out of 24 individuals consented. Instruments used for data collection were “Quality from the Patient's Perspective,” “Wound‐Quality of Life,” “Modified Norton Scale,” and a study developed protocol for the mobile team's PU interventions.ResultsThe patients chose home visits 20 times and outpatient clinic visits 89 times. In total, 8–13 interventions per participant were performed by the mobile team. The results show that having PUs affected the participants' perceptions of care and general well‐being. The PUs did not heal completely but they did improve, six patients underwent flap surgery.ConclusionWhen organizing care regarding patient safety for patients with deep PUs, it is important to consider the patient's perspective and well‐being and to involve patients in their care plans. Home care is perhaps not the only way of caring; other aspects, in addition to telemedicine, could be an option.
Machine learning approaches to predict the need for intensive care unit admission among Iranian COVID‐19 patients based on ICD‐10: A cross‐sectional study
Authors: Karimi Zahra , Malak Jaleh S. , Aghakhani Amirhossein , Najafi Mohammad S. , Ariannejad Hamid , Zeraati Hojjat , Yekaninejad Mir S. 
Published: September 2024

AbstractBackground & AimTimely identification of the patients requiring intensive care unit admission (ICU) could be life‐saving. We aimed to compare different machine learning algorithms to predict the requirements for ICU admission in COVID‐19 patients.MethodsWe screened all patients with COVID‐19 at six academic hospitals in Tehran comprising our study population. A total of 44,112 COVID‐19 patients (≥18 years old) were included, among which 7722 patients were hospitalized. We used a Random Forest algorithm to select significant variables. Then, prediction models were developed using the Support Vector Machine, Naıve Bayes, logistic regression, lightGBM, decision tree, and K‐Nearest Neighbor algorithms. Sensitivity, specificity, accuracy, F1 score, and receiver operating characteristic‐Area Under the Curve (AUC) were used to compare the prediction performance of different models.ResultsBased on random Forest, the following predictors were selected: age, cardiac disease, cough, hypertension, diabetes, influenza & pneumonia, malignancy, and nervous system disease. Age was found to have the strongest association with ICU admission among COVID‐19 patients. All six models achieved an AUC greater than 0.60. Naıve Bayes achieved the best predictive performance (AUC = 0.71).ConclusionNaïve Bayes and lightGBM demonstrated promising results in predicting ICU admission needs in COVID‐19 patients. Machine learning models could help quickly identify high‐risk patients upon entry and reduce mortality and morbidity among COVID‐19 patients.
Prevalence of opportunistic intestinal coccidian parasites and associated factors in HIV/AIDS patients attending anti‐retroviral therapy (ART) clinic at Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia: A cross‐sectional study
Authors: Almaw Andargachew , Assefa Ayenew , Berhan Ayenew , Getahun Ermiyas , Sharew Bekele , Tiruneh Tegenaw , Getie Birhanu , Erkihun Mulat , Solomon Yenealem , Legese Biruk , Kiros Teklehaimanot , Abebaw Aynework 
Published: September 2024

AbstractBackground and AimsA growing number of acquired immunodeficiency syndrome (AIDS) patients suffer from opportunistic intestinal coccidian infections. Instead of human immuno deficiency virus (HIV) infection itself, opportunistic infections like intestinal coccidian parasites cause death of over 80% AIDS patients. Factors like exposed drinking water sources and poverty aid the prevalence of opportunistic intestinal coccidian parasitic infections in HIV/AIDS patients. The goal of this study was to determine the prevalence of intestinal coccidian parasites and associated factors in HIV/AIDS patients.MethodsA health facility based cross sectional study was conducted from 140 HIV/AIDS patients attending ART clinic in Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia from September to December 2023. The sociodemographic characteristics were collected through face‐to‐face interviews. Stool samples were processed with Modified Acid Fast staining technique. Statistical Package for Social Sciences software version 20 was used to analyze the data. Logistic regression was used to assess factors associated with dependent variable and p < 0.05 was considered significantly associated.ResultsThe total prevalence of opportunistic intestinal coccidian parasites (OICPs) in HIV/AIDS patients was 16.4% (23/140). Drinking surface water [p = 0.015, COR = 3.4] compared to tape water, drinking alcohol [p = 0.001, COR = 18] compared to not drinking alcohol, diarrhea [p = 0.005, COR = 1] compared to non‐diarrheic, drug dropout [p = 0.01, COR = 11] compared to regular drug intake and low CD4 count [p = 0.042, COR = 9] compared to CD4 > 500/µL showed significant association with increased prevalence of OICPs in HIV/AIDS patients.ConclusionsOICPs are still the common causes of morbidity and mortality in HIV/AIDS patients. Surface water consumption, alcoholism, interruption of treatment drugs, diarrhea, and reduced CD4+ T‐cells significantly contribute to acquisition and prevalence of OICPs in HIV/AIDS patients. Routine screening of OICPs with sensitive diagnostic techniques in HIV/AIDS patients regardless of symptoms is crucial and has to be practiced in health settings.
Mastering nonobstetric surgery in pregnancy: Insights, guidelines evaluation, and point‐by‐point discussion
Authors: Pecorella Giovanni , Sparic Radmila , Morciano Andrea , Constantin Silviu Mihai , Babovic Ivana , de Rosa Filippo , Tinelli Andrea 
Published: September 2024

AbstractFor surgeons and clinicians, nonobstetric surgery during pregnancy has certain difficulties and considerations. In order to aid in decision‐making in these situations, this manuscript offers a thorough review of the guidelines currently in place from renowned obstetric and surgical societies, such as the American College of Obstetricians and Gynecologists, the Royal College of Obstetricians & Gynecologists, and others. Using AGREE II‐S methodology, a comprehensive analysis of guidelines reveals differences in recommendations for anesthetics, surgical procedures, imaging modalities, and thromboembolic prophylaxis. Furthermore, a thorough discussion of strategic surgical planning is provided, covering aspects such as patient positioning, trocar placement, pneumoperitoneum generation, and thromboembolic risk management. The publication highlights that in order to maximize the results for both the mother and the fetus after nonobstetric surgery performed during pregnancy, a multidisciplinary approach and evidence‐based decision‐making are essential.
Sangerbox 2: Enhanced functionalities and update for a comprehensive clinical bioinformatics data analysis platform
Authors: Chen Di , Xu Lixia , Xing Huiwu , Shen Weitao , Song Ziguang , Li Hongjiang , Zhu Xuqiang , Li Xueyuan , Wu Lixin , Jiao Henan , Li Shuang , Yan Jing , He Yuting , Yan Dongming 
Published: September 2024

AbstractIn recent years, development in high‐throughput sequencing technologies has experienced an increasing application of statistics, pattern recognition, and machine learning in bioinformatics analyses. SangeBox platform to meet different scientific demands. The new version of Sangs is a widely used tool among many researchers, which encourages us to continuously improve the plerBox 2 (http://vip.sangerbox.com) and extends and optimizes the functions of interactive graphics and analysis of clinical bioinformatics data. We introduced novel analytical tools such as random forests and support vector machines, as well as corresponding plotting functions. At the same time, we also optimized the performance of the platform and fixed known problems to allow users to perform data analyses more quickly and efficiently. SangerBox 2 improved the speed of analysis, reduced resource required for computer performance, and provided more analysis methods, greatly promoting the research efficiency.
Local officials' hometown preference and enterprises' environmental investment behavior
Authors: Li Na 
Published: September 2024

AbstractBased on annual observations of heavily polluting enterprises of A‐share listed companies from 2012 to 2019, this paper analyzes the impact of officials' preference for enterprises' investment in environmental protection in the officials' hometowns. It is found that when the Secretary of the municipal Party Committee takes office in his or her hometown, environmental protection investment by enterprises is higher, indicating that the preference of the municipal Party Secretary for their hometown has a positive promoting effect on enterprises' environmental governance behavior. At the same time, officials' hometown preferences promote environmental investment by strengthening environmental supervision. It is further found that the longer the municipal Party Secretary works in his or her hometown, the higher his or her education level, and the older he or she is, the greater the impact of his or her hometown preference on enterprises' environmental protection investment. Compared with female Party Secretaries, male Party Secretaries have more significant influence on corporate behavior. At the same time, corporate characteristics such as enterprise scale and regional characteristics such as economic development have a certain regulatory effect on this promoting effect.
Use of Zebrafish (Danio rerio) for Biosafety Evaluation of Strontium Nanostructured Hydroxyapatite
Authors: da Costa Silva Elisângela , de Souza Augusto Monteiro , Rossi Alexandre Malta , Costa Andrea Machado , Grangeiro José Mauro , Luchiari Ana Carolina , de Medeiros Silvia Regina Batistuzzo 
Published: September 2024

ABSTRACTDespite the numerous studies on biocompatibility with nano‐biomaterials, the biological effects of strontium‐substituted HA nanoparticles (nSrHA) need to be better understood. So, we conducted an embryotoxicity test using zebrafish (Danio rerio) according to the OECD 236 guideline, a model that represents a viable alternative that bridges the gap between in vitro and mammalian models. Zebrafish embryos were exposed for 120 h to microspheres containing nSrHA nanoparticles with low and high crystallinity, synthesized at temperatures of 5°C (nSrHA5) and 90°C (nSrHA90). We evaluated lethality, developmental parameters, and reactive oxygen species (ROS) production. The larval behavior was assessed at 168 hpf to determine if the biomaterials affected motor responses and anxiety‐like behavior. The results showed that the survival rate decreased significantly for the nSrHA5 group (low crystalline particles), and an increase in ROS was also observed in this group. However, none of the biomaterials caused morphological changes indicative of toxicity during larval development. Additionally, the behavioral tests did not reveal any alterations in all experimental groups, indicating the absence of neurotoxic effects from exposure to the tested biomaterials. These findings provide valuable insights into the biosafety of modified HA‐based nanostructured biomaterials, making them a promising strategy for bone tissue repair. As the use of hydroxyapatite‐based biomaterials continues to grow, it is crucial to ensure rigorous control over the quality, reliability, and traceability of these materials.
Efficacy of Low‐Dose Scopolamine and Palonosetron in Reducing Immediate Post‐Gastrointestinal Endoscopy Nausea and Vomiting: A Prospective, Randomized, Controlled Study
Authors: Lin Jianghuai , Cai Zhiming , Lin Yingzi , Wu Huanghui , Gu Yu 
Published: September 2024

AbstractThis study aimed to assess the incidence of post‐discharge nausea and vomiting (PDNV) following sedation with nalbuphine and etomidate and to evaluate the prophylactic effects of scopolamine in reducing PDNV. A two‐stage prospective clinical trial was conducted. The first part involved an observational study of 77 subjects to assess the PDNV incidence post‐sedation with nalbuphine, etomidate, and propofol. The second part compared the effectiveness of palonosetron 0.075 mg (P group), scopolamine 0.1 mg (S group), and their combination (PS group) in reducing PDNV. The primary endpoint was the incidence of PDNV within 8 h post‐sedation. Secondary outcomes included PDNV frequency and severity at 8–24, 0–24, and 24–48 h and side effects of medications. The incidence of PDNV within 8 h post‐sedation was 37.66% (29/77). The PS group showed a significantly lower PDNV rate of 2.56% within 8 h, compared to the P group (35.71%, P < .001), S group (19.64%, P < .001), and control group (38.39%, P < .001), respectively. The S group (19.64%) also had a lower rate than the P group (35.71%, P = .007) and the control group (38.39%, P = .002). Subgroup analysis suggested a potential differential effect of palonosetron in reducing vomiting among male patients undergoing gastrointestinal procedures. The combination therapy was also associated with fewer cases of mild or no nausea and vomiting. In summary, the incidence of PDNV following sedation with nalbuphine and etomidate was notably high. The combination of scopolamine and palonosetron was more effective in preventing PDNV, with implications for improved post‐sedation care.
Effects of Flammulina velutipes powder on the emulsion properties of chicken myofibrillar protein under low‐salt conditions
Authors: Fu Qingquan , Qin Chun , Chen Quanzhan , Zhang Wei , Han Miaomiao 
Published: September 2024

AbstractThis study aimed to investigate the influence of varying concentrations of Flammulina velutipes powder (FVP) (0, 4, 8, 12, 16, and 20 g L−1, based on FVP weight per liter of emulsion) on the stability, rheological properties, microstructure, and interfacial protein content of chicken myofibrillar protein (MP) emulsions under low‐salt conditions. Visual assessment and the Turbiscan stability index revealed that the stability of MP emulsions improved with increasing FVP concentration. The greatest stability was achieved when the FVP concentration was 16 gL−1. The incorporation of FVP enhanced the elasticity and viscosity of the emulsions by forming a dense three‐dimensional network structure. The droplet size of the emulsions initially decreased and then increased with increasing FVP concentration. The addition of FVP increased the amount of protein absorbed by the emulsion layer. Flammulina velutipes powder is promising as a stabilizer that could improve the emulsifying and functional properties of low‐salt myofibrillar protein emulsions. © 2024 Society of Chemical Industry.
“Whether and how digital celebrities make us hungry for travel?”—An exploration of broadening and constructing perspectives on gastronomic tourism
Authors: Zhou Jieling , Xiang Keheng , Wang Mengyao , Zhao Yangke 
Published: September 2024

AbstractThis study explored the influence of digital celebrities on gastronomic tourism through the lens of the broaden‐and‐build theory. Utilizing partial least squares structural equation modeling (PLS‐SEM) and a case study focused on TikTok, the research examined how consumers' subjective well‐being (SWB) affects para‐social interaction, novelty seeking, and audience participation, and how these factors, in turn, influence behavioral intention in the domains of food and travel. The results validated the proposed hypotheses, underscoring the importance of SWB in shaping behavioral intention within gastronomic tourism driven by digital celebrities. This paper enhances the current literature by elucidating the role of digital celebrities in gastronomic tourism and offers practical insights for marketers and tourism professionals on optimizing the influence of digital celebrities to improve the gastronomic tourism experience.
Optimizing the patellofemoral compartment in total knee arthroplasty: Is it time for dynamic assessment?
Authors: Koutserimpas Christos , Saffarini Mo , Bonnin Michel , Hirschmann Michael T. , Lustig Sébastien 
Published: September 2024

AbstractDespite improvements in implant design, surgical techniques and assistive technologies for total knee arthroplasty (TKA), anterior knee pain (AKP) remains frequently reported, even by satisfied patients. This persistent problem calls for better understanding and management of the patellofemoral or anterior compartment during surgery, just as the techniques and strategies deployed to optimize the flexion and extension spaces through personalized alignment, bone cuts and ligament balancing. Assistive technologies such as navigation and robotics provide new tools to manage this ‘third space’ through precise pre‐operative planning and dynamic intra‐operative assessment. Such endeavors must start with clear definitions of the ‘third space’, how it should be measured, what constitutes its ‘safe zone’, and how it affects outcomes. There are yet no established methods to evaluate the patellofemoral compartment, and no clear thresholds to define over‐ or under‐stuffing. Static assessment using lateral radiographs provides a limited understanding and depends considerably on flexion angle, while dynamic evaluation at multiple flexion angles or using intra‐operative computer or robotic‐assistance enables a broader perspective and solutions to manage patellar tracking and anterior offset. Future studies should investigate the impact of variations in anterior offset in TKA, define its safe zone, and understand the effects of of thresholds for over‐ or under‐stuffing. Experimental methods such as in‐vivo motion analysis and force sensors could elucidate the influence of anterior offset on flexion and extension biomechanics.
Decoupling of Phase and Amplitude Channels with a Terahertz Metasurface Toward High‐Security Image Hiding
Authors: Zhao Huan , Nan Tong , Wang Xinke , Liu Siyuan , Chen Zhuo , Sang Yungang , Wang Yu , Han Chunrui , Zhang Yan 
Published: September 2024

AbstractSteganography technology which conceals a message in a carrier to make it invisible is critical for information security. Conventional optical image steganography using diffractive optical components or spatial light modulators suffers from less encoding channel and bulky volume. The emergence of multifunctional metasurface that can manipulate abundant physical dimensions of optical fields allows the multi‐channel image steganography in a compact volume. Here, the image hiding in a metasurface is demonstrated by modulating the amplitude, phase, and polarization states of terahertz (THz) waves completely. Especially, the phase channel can decouple from the amplitude channel based on a Fresnel‐diffraction‐based algorithm. By directly measuring the phase distribution using the homemade THz focal plane imaging system, the number of transmission channels can expand from N to 2N. As a proof of concept, it is shown that the secret images can encode in the phase channel and subsequently extract by using different keys, such as polarization states, detection distances, and its combinations. Moreover, different hiding strategies with different attacker behaviors are also demonstrated. The decoupling of the phase and amplitude channels with a single metasurface may open an avenue toward innovative optoelectronic devices for optical image steganography, data storage, and terahertz communication.
Ultrafast Four‐Wave Mixing Phase‐Matched by Transient Nonlinear Phase Modulation in a MAPbBr3 Single Crystal
Authors: Ren Jiahui , Zhang Xinping 
Published: September 2024

AbstractA degenerated four‐wave‐mixing (FWM) process in single‐crystal (CH3NH3)PbBr3 (MAPbBr3) is reported, where 150‐fs laser pulses at 1.33 µm are employed as the pump. Two pump photons interact with a single crystal, producing another two photons with higher and lower energies, respectively. One of the FWM‐generation sidebands is tuned from ∼1.23 to 1.21 µm and the other from ∼1.43 to 1.48 µm for the center wavelength, as the pump fluence is increased from 2.6 to 11.69 mJ cm−2. The self‐phase modulation induced by the strong pump pulses through the optical Kerr effect is responsible for the tuning dynamics. Transient spectroscopy not only verifies the FWM scheme for the interacting waves but also reveals the interference dynamics between the FWM‐generated sidebands and the probe pulse. In particular, the angular dependence of the FWM generation supplies direct evidence for the phase‐matching geometry. Using experimental data, a nonlinear refractive index coefficient of 1.19 × 10−14 cm2 W−1 at 1.33 µm for single‐crystal MAPbBr3 is determined.