bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Watershed‐Scale Simulations of In‐Stream Pesticide Concentrations from Off‐Target Spray Drift
Authors: Winchell Michael F. , Pai Naresh , Brayden Benjamin H. , Stone Chris , Whatling Paul , Hanzas John P. , Stryker Jody J. 
Published: January 2018

The estimation of pesticide concentrations in surface water bodies is a critical component of the environmental risk assessment process required by regulatory agencies in North America, the European Union, and elsewhere. Pesticide transport to surface waters via deposition from off‐field spray drift can be an important route of potential contamination. The spatial orientation of treated fields relative to receiving water bodies make prediction of off‐target pesticide spray drift deposition and resulting aquatic estimated environmental concentrations (EECs) challenging at the watershed scale. The variability in wind conditions further complicates the simulation of the environmental processes leading to pesticide spray drift contributions to surface water. This study investigates the use of the Soil Water Assessment Tool (SWAT) for predicting concentrations of malathion (O,O‐deimethyl thiophosphate of diethyl mercaptosuccinate) in a flowing water body when exposure is a result of off‐target spray drift, and assesses the model's performance using a parameterization typical of a screening‐level regulatory assessment. Six SWAT parameterizations, each including incrementally more site‐specific data, are then evaluated to quantify changes in model performance. Results indicate that the SWAT model is an appropriate tool for simulating watershed scale concentrations of pesticides resulting from off‐target spray drift deposition. The model predictions are significantly more accurate when the inputs and assumptions accurately reflect application practices and environmental conditions. Inclusion of detailed wind data had the most significant impact on improving model‐predicted EECs in comparison to observed concentrations.Core Ideas
SWAT can simulate pesticide concentrations resulting from off‐target spray drift deposition.
Screening‐level assumptions produce extremely conservative (high) concentrations.
Predictions are more accurate when inputs reflect site‐specific data.
Inclusion of actual wind data had the greatest impact on improving model results.
Identifikasi Spatial Pattern dan Spatial Autocorrelation pada Indeks Pembangunan Manusia Provinsi Papua Barat Tahun 2012
Authors: Nisa Eva Khoirun 
Published: January 2018

<p align="center">One of the support aspect the country development is human resource quality. When we talking about human resource quality, it’s not separated with human development. The international standard of human development is Human Development Index (HDI). HDI becomes important indicator in West Papua province which is one of the youngest provinces in Papua. There is spatial effect of human development condition among districts in West Papua. Spatial Pattern and Spatial Autocorrelation as statistical methods can be used to identify HDI dependency among districts in West Papua. The statistical tests on Spatial Autocorrelation has found that there was no spatial independency of HDI on 2017 among districts in West Papua province.</p><p>==================================================</p><p> </p><p>Salah satu aspek yang mendukung pembangunan suatu negara adalah kualitas sumber daya manusia. Berbicara mengenai kualitas sumber daya manusia maka tidak lepas dengan pembangunan manusia. Ukuran standar pembangunan manusia yang dapat digunakan secara internasional yaitu Indeks Pembangunan Manusia (IPM) atau <em>Human Development Index</em> (HDI). IPM menjadi hal yang penting bagi Provinsi Papua Barat mengingat Papua Barat menjadi salah satu provinsi termuda hasil pemekaran wilayah Provinsi Papua. Sangat dimungkinkan adanya pengaruh spasial pada kondisi pembangunan manusia antar kabupaten/kota di Provinsi Papua Barat.<em> Spatial Pattern</em> dan <em>Spatial Autocorrelation</em> menjadi metode statistika yang dapat mengidentifikasi adanya dependensi IPM antar kabupaten/kota di Provinsi Papua Barat. Dengan beberapa pengujian statistik <em>Spatial Autocorrelation</em> menghasilkan bahwa tidak terdapat dependensi spasial terhadap angka IPM pada tahun 2012 antar kabupaten/kota di Provinsi Papua Barat.</p><p> </p><p> </p>
Suppression of nutrient release from freshwater lake sediments using granulated coal ash
Authors: Fukushima Takehiko , Okabe Masako , Hibino Tadashi , Touch Narong , Nakamoto Kenji 
Published: January 2018

Abstract
In order to investigate the applicability of granulated coal ash (GCA), a by-product of coal thermal power stations, to freshwater lakes, two incubation experiments (fall and summer experiments) were conducted using large-volume vessels and sediments taken from eutrophic lakes. The phosphorus and nitrogen release fluxes in the vessels with GCA (up to 2.9 mg m−2 d−1 for total phosphorus and 23.9 mg m−2 d−1 for total nitrogen) were considerably smaller than those in the vessels without GCA (up to 8.9 mg m−2 d−1 and 56 mg m−2 d−1, respectively), except in the case of phosphorus in the fall experiment, and thus the phosphorus concentration released from the vessel without GCA under anoxic conditions in the summer experiment was extraordinarily higher (over 1.5 mg l−1) than those in the other vessels (less than 0.31 mg l−1). Supplementary experiments with smaller columns indicated that the chemical effect of GCA was on a similar level with its physical effect and that the threshold phosphorus concentration for removing it was lower in freshwater than seawater. The chromium level slightly exceeded the standard for drinking water and the development of technology to suppress its release is a future challenge.
Chemistry in the Bioactivity of Chlorophylls: An Overview
Authors: Perez-Galvez Antonio , Viera Isabel , Roca Maria 
Published: January 2018

Background:
In addition to the considerable number of different chlorophyll
structures originated naturally, prominent research is made to produce new specific semisynthetic
structures. The final target is to obtain chlorophyll derivatives with even better
bioactive properties than those of the natural parent compounds.

Method:
A detailed, extensive and critic literature search has been made in Web of
Science™.

Results:
Great efforts are applying to optimize the function of chlorophyll-based photosensitizers,
to understand the molecular mechanisms of the antioxidant and antigenotoxic
properties of chlorophyll derivatives and, lastly, to investigate new biological actions of
them. However, the fundamental physiological functions of the chlorophylls are their
physicochemical properties.

Conclusion:
This review aims to reflect the chemical grounds of the healthy and/or medical
features of chlorophylls, including the consequences, advantages or even new actions
that modifications over the chlorophyll structure introduce. Finally, new perspectives in
the functionality of chlorophylls at molecular level are discussed.
Synthesis and Biological Evaluation of Novel Triazoles Linked 7-hydroxycoumarin as Potent Cytotoxic Agents
Authors: Farooq Saleem , Hussain Aashiq , Qurishi Mushtaq A. , Hamid Abid , Koul S. 
Published: January 2018

Background:
BacCancer is regarded as second leading cause of death worldwide. Therefore, there is
a high demand for the discovery, development and improvement of novel anti-cancer agents which could efficiently
prevent proliferative pathways and clonal expansion of cells.

Objective:
In view of this, a new series of bioactive scaffolds viz triazoles linked 7-hydroxycoumarin (1) were
synthesized using click chemistry approach.

Method:
All the synthesized compounds were screened for cytotoxicity against a panel of seven different human
cancer cell lines viz. Colon (Colo-205 and HCT-116), breast (MCF-7), lung (NCI-H322 and A549), prostate
(PC-3) and skin (A-431) using 3-(4,5-Dimethylthiazol-yl)-diphenyl tetrazoliumbromide (MTT) assay.

Results:
Among all tested analogs, compound 5, displayed better cytotoxic activity as compared to the parent 7-
hydroxycoumarin (1) with IC50 of 5.1, 22.7, 14.3 and 10.2 µM against breast (MCF-7), lung (NCI- H322), prostate
(PC-3) and skin (A-431) cancer cell lines, respectively; the compound 5 was 8-fold more sensitive against
MCF-7 than the parent 7-hydroxycoumarin. Moreover, Compound 5 induced both cytotoxic as well as cytostatic
effects via induction of apoptosis and G1 phase arrest, respectively in breast cancer cells (MCF-7). The apoptotic
cell population enhanced to 18.8% at 8 µM of 5 from 9.8% in case of negative control, while G1 phase arrest
increased to 54.4% at 8 µM compared to negative control of 48.1%. Moreover, Compound 5 also exhibited a
remarkable decrease in mitochondrial membrane potential (ΛΨm) leading to apoptosis of cancer cells used.

Conclusion:
The structure-activity relationship study revealed that the derivatives bearing electron-withdrawing
substituents were more effective. The present study resulted in identification of the compounds demonstrating
broad spectrum cytotoxic activity.
PEMAHAMAN LITERASI MEDIA DI LINGKUNGAN PENGURUS PIMPINAN WILAYAH AISYIYAH DAERAH ISTIMEWA YOGYAKARTA PERIODE 2015-2020
Authors: Ulfah Mariana , Fajri Choirul , Fadillah Dani 
Published: January 2018

As parents mothers play an important role in giving directions to targeted all relating to the event who deserves to consume by family. This study was conducted by adopting descriptive quantitative. Handing out the questionnaire to the Leader of ‘Aisyiyah DIY the period 2015-2020. The result of shows that there has been understanding of literacy media of ‘Aisyiyah DIY, the attitude shown to the son of/his daughter in preventing negative effects impressions television. But of the that good, do not affect significantly to the attitudes shown. Sebagai orang tua Ibu memiliki peran penting dalam memberikan arahan kepadaputra-putrinya terkait dengan acara yang layak untuk dikonsumsi keluarga. Penelitianini dilaksanakan dengan menggunakan pendekatan deskriptif kuantitatif. Denganmembagikan kuesioner kepada Pengurus Pimpinan Wilayah Aisyiyah Yogyakartaperiode 2015-2020. Hasil dari menunjukkan adanya pemahaman dari literasi mediaPengurus PWA ‘Aisyiyah DIY, adanya sikap yang ditunjukkan kepada putra/putrinyadalam mencegah dampak buruk tayangan televisi. Akan tetapi dari pemahaman yangbaik tersebut, tidak berpengaruh secara signifikan terhadap sikap yang ditunjukkan.
Pengaruh ukuran sampel dan intraclass correlation coefficients (ICC) terhadap bias estimasi parameter multilevel latent variable modeling: studi dengan simulasi Monte Carlo
Authors: Putra Muhammad Dwirifqi Kharisma , Umar Jahja , Hayat Bahrul , Utomo Agung Priyo 
Published: January 2018

Studi ini menggunakan simulasi Monte Carlo dilakukan untuk melihat pengaruh ukuran sampel dan intraclass correlation coefficients (ICC) terhadap bias estimasi parameter multilevel latent variable modeling. Kondisi simulasi diciptakan dengan beberapa faktor yang ditetapkan yaitu lima kondisi ICC (0.05, 0.10, 0.15, 0.20, 0.25), jumlah kelompok (30, 50, 100 dan 150), jumlah observasi dalam kelompok (10, 20 dan 50) dan diestimasi menggunakan lima metode estimasi: ML, MLF, MLR, WLSMV dan BAYES. Jumlah kondisi keseluruhan sebanyak 300 kondisi dimana tiap kondisi direplikasi sebanyak 1000 kali dan dianalisis menggunakan software Mplus 7.4. Kriteria bias yang masih dapat diterima adalah < 10%. Hasil penelitian ini menunjukkan bahwa bias yang terjadi dipengaruhi oleh ukuran sampel dan ICC, penelitian ini juga menujukkan bahwa metode estimasi WLSMV dan BAYES berfungsi lebih baik pada berbagai kondisi dibandingkan dengan metode estimasi berbasis ML.Kata kunci: multilevel latent variable modeling, intraclass correlation coefficients, Metode Markov Chain Monte Carlo THE IMPACT OF SAMPLE SIZE AND INTRACLASS CORRELATION COEFFICIENTS (ICC) ON THE BIAS OF PARAMETER ESTIMATION IN MULTILEVEL LATENT VARIABLE MODELING: A MONTE CARLO STUDYAbstractA monte carlo study was conducted to investigate the effect of sample size and intraclass correlation coefficients (ICC) on the bias of parameter estimates in multilevel latent variable modeling. The design factors included (ICC: 0.05, 0.10, 0.15, 0.20, 0.25), number of groups in between level model (NG: 30, 50, 100 and 150), cluster size (CS: 10, 20 and 50) to be estimated with five different estimator: ML, MLF, MLR, WLSMV and BAYES. Factors were interegated into 300 conditions (4 NG 3 CS 5 ICC 5 Estimator). For each condition, replications with convergence problems were exclude until at least 1.000 replications were generated and analyzed using Mplus 7.4, we also consider absolute percent bias <10% to represent an acceptable level of bias. We find that the degree of bias depends on sample size and ICC. We also show that WLSMV and BAYES estimator performed better than ML-based estimator across varying sample sizes and ICC’s conditions.Keywords: multilevel latent variable modeling, intraclass correlation coefficients, Markov Chain Monte Carlo method
Outcomes research examining treatments, quality of life and costs in
HER2
-negative and triple-negative metastatic breast cancer: a systematic literature review
Authors: Parisi Monika , Pelletier Corey , Cherepanov Dasha , Broder Michael S 
Published: January 2018

Aim:
With the aggregation of real-world data in healthcare, opportunities for outcomes research are growing. In this study, we summarize published literature examining comparative effectiveness research (CER), treatment patterns, quality of life (QoL) and costs in
HER2
-negative and triple-negative (TN) metastatic breast cancer (mBC).
Methods:
PubMed (2010–January 2016) and four conferences (2013–January 2016) were searched using MeSH/keywords, including mBC, QoL, morbidity and therapeutics. Studies relating to CER, treatment patterns, QoL, costs or treatment appropriateness in US patients with
HER2
-negative/TN mBC were included in the review.
Results:
Of 1782 identified records, 33 studies met full inclusion criteria: seven related to CER, 18 to treatment patterns, one to treatment appropriateness/navigation, two to QoL and five to costs. Studies varied in objectives, designs and outcomes. Study designs included retrospective chart reviews (52%), retrospective secondary database analyses (27%), economic models (12%), physician surveys (6%) and patient surveys (3%). 25 studies reported results on
HER2
-negative mBC, six on TN mBC and two on both subtypes. The most common end points examined were treatment patterns, overall survival and progression-free survival.
Conclusion:
Outcomes research in
HER2
-negative mBC in the USA was limited, specifically among TN patients, indicating an opportunity for further research in this high unmet need population. Endpoints and treatment options varied, thus, it is difficult to draw summary conclusions about these studies. Outcomes research examining real-world data in mBC has increased in recent years, and may continue to grow with the implementation of new policy programs.
Abordaje en el diagnóstico y tratamiento de la tuberculosis drogorresistente en el Hospital Infantil Dr. Robert Reid Cabral 2006-2015
Authors: Pantaleón Elsa Camilo , Melgen Ricardo Elias , Espaillat Terrero Carmen , Cordero Onate Leandra , Hernández Florentino Alcedo , Hatton Paola , Lazala Adria , Abreu Gutiérrez Narielys 
Published: January 2018

En este trabajo se presenta la revisión de 95 casos de pacientes menores de 18 años, 61 de los cuales son menores de 5 años (64.2%). El 74% de ellos tuvo un tiempo de exposición mayor de un año a la tuberculosis antes de la evaluación; el 94.7% (90) refirió contacto drogoresistente, mientras el 92% (83) fue intradomiciliario. En cuanto a los resultados, hubo 5 casos de fracaso a tratamiento con drogas de primera línea, 20 pacientes sintomáticos respiratorios (tos, fiebre, dificultad respiratoria) (21%), así como con adenopatías cervicales y pérdida de peso. La prueba de tuberculina (PPD) aplicada a 71 pacientes (75%) reportó 44 resultados positivos (62%). De las radiografías de tórax al 100% de los pacientes, 14 de ellas fueron patológicas (14.7%). Hubo 9 baciloscopías positivas (26.4%) y 10 cultivos positivos (52%), 79 pacientes resultaron contactos sanos (83%) y 16 pacientes (17%) iniciaron su tratamiento con el diagnóstico de Tuberculosis Multidrogo Resistente (TB-MDR). De los casos de TB-MDR confirmadas o probables, aparecen 8 pacientes de 11 a 15 años (50%) y 2 menores de 1 año de edad; 9 pacientes (56.2%) TB-MDR nunca antes tratados (primarios) y 97 secundarios al uso de drogas de primera línea. Asimismo, PPD positiva en 10 pacientes y radiografía patológica en 15. La baciloscopía resultó positiva en 9 pacientes y el cultivo en 10. Resistencia a Isoniacida (H) y Rifampicina (R) observada en 10 pacientes (62%), patrones de resistencia similares al caso índice. Resumiendo, 14 casos fueron pulmonares (87.6%) y 2 ganglionares (12.5%). Los contactos sanos seguidos por dos años no desarrollaron la enfermedad; mientras que los pacientes con diagnóstico confirmado o presuntivo de TB-MDR recibieron tratamiento con el esquema estandarizado (inyectables, Pirazinamida, Etionamida, Cicloserina, Quinolonas) por 18 meses, mostrando una curación del 75% (12). Dos pacientes abandonaron el tratamiento antes de finalizar y solamente hubo un fracaso a tratamiento. A modo de conclusión, encontramos tardanza en la evaluación de los contactos; 17% de los pacientes evaluados fueron diagnosticados con TB-MDR; la curación se evidenció en el 75% de ellos; y, por último, los pacientes sanos seguidos sin tratamiento no desarrollaron la enfermedad, lo cual nos ubica dentro de lo esperado en manejo de TB-MDR a nivel mundial.
PERCEPÇÃO DOS USUÁRIOS SOBRE AS AÇÕES EDUCACIONAIS DE ALIMENTAÇÃO E NUTRIÇÃO NO SISTEMA ÚNICO DE SAÚDE
Authors: Aquino Anna Caroline Ferreira , Alves Beatriz Moreira Santos , Pinho Lucinéia 
Published: January 2018

Iniciativas de educação no âmbito nutricional são indispensáveis e a incidência de hipertensão e diabetes mellitus aumenta a necessidade de abordagem integral. Esta pesquisa teve o objetivo de avaliar a percepção do usuário sobre as ações educacionais de alimentação e nutrição no Sistema Único de Saúde entre os participantes dos grupos para diabéticos e hipertensos nas Estratégias Saúde da Família. Para tanto, realizou-se uma pesquisa analítico--descritiva, com abordagem qualitativa, por meio de entrevistas semiestruturadas realizadas com participantes dos grupos de educação em saúde de Hipertensão e Diabetes nas Estratégias Saúde da Família em Montes Claros, Minas Gerais. As entrevistas foram transcritas e, utilizando da técnica análise de conteúdo, foram categorizadas por ideias centrais: 1º ideia central: “Alimentação no grupo?”; 2º ideia: Orientações: “Receitas de Bolo”; 3º ideia: “Por além da fala”; 4º ideia: “Quero Nutricionista”. Por meio da análise das falas, foi possível compreender que as ações educacionais de alimentação realizadas nos grupos de educação em saúde contribuem singularmente nos hábitos dos usuários. Concluiu-se que, apesar de orientações sobres alimentação serem realizadas, elas mostraram-se insuficientes, seja pelo fato de terem sido ministradas por profissionais que não detinham o conhecimento necessário para realizá-las, seja pela não utilização de métodos adequados.
Palavras-chave: Atenção Primária à Saúde. Alimentação e Nutrição. Ações Educacionais.
ACIDENTES DE TRABALHO COM EXPOSIÇÃO A MATERIAL BIOLÓGICO: OCORRÊNCIAS EM PROFISSIONAIS DE SAÚDE EM UM HOSPITAL GERAL
Authors: Lima Ronaldo de Oliveira , Vieira Diego Barboza , De Cerqueira Erenilde Marques , Miranda Gilca Lessa , Santana Eloisa Bahia 
Published: January 2018

A exposição a material biológico por acidente é um fato um tanto quanto frequente em acidentes de trabalho envolvendo profissionais de saúde, figurando como um risco para a saúde do profissional e do paciente, posto que o material é potencialmente infectante e por indicar a possibilidade de soroconversão. O objetivo desse estudo foi analisar os acidentes ocupacionais com exposição a material biológico envolvendo profissionais de saúde no Hospital Geral Clériston Andrade no município de Feira de Santana. Teve como método o estudo do tipo corte transversal, de abordagem quantitativa, sendo utilizadas as notificações de acidentes ocupacionais com exposição a material biológico envolvendo profissionais de saúde que foram notificados no hospital em estudo nos anos de 2011 e 2012. Foram analisados 254 acidentes. Os resultados indicaram que a categoria profissional mais acometida foi a dos técnicos e auxiliares de enfermagem (47,6%). A maioria dos acidentes ocorreram durante punções (21,3%); quanto à situação vacinal, 88,1% estavam devidamente vacinados. Com isso, concluiu-se que é importante a implantação de estratégias que visem a capacitar os profissionais na notificação, no uso de medidas profiláticas e nas condutas a serem tomadas frente aos acidentes com exposição a material biológico.
Palavras-chave: Acidentes de trabalho. Riscos ocupacionais. Pessoal de saúde.
CONSTRUÇÃO DE UMA LINHA DE CUIDADO NEONATAL: PERCEPÇÃO DOS PROFISSIONAIS DA ATENÇÃO BÁSICA À SAÚDE
Authors: Berwig Luana Cristina , Dos Santos Chariani Gugelmin Basso , De Carvalho Fabiane Luz Luz , Jurach Gabriela de Almeida , Pimenta Lizandra Flores , Weiller Teresinha Heck 
Published: January 2018

A linha de cuidado é uma estratégia que visa aos fluxos assistenciais seguros e garantidos ao usuário no Sistema Único de Saúde. O objetivo deste artigo foi analisar a percepção de profissionais da Atenção Básica à Saúde sobre a linha de cuidado neonatal. Realizou-se pesquisa qualitativa. Foram aplicadas entrevistas semiestruturadas a sete enfermeiros e cinco médicos pediatras de Unidades Básicas de Saúde do município de origem. Por meio da análise de conteúdo, emergiram duas categorias: percepção de profissionais sobre a linha de cuidado neonatal e construção da linha de cuidado neonatal. Os resultados mostraram que a Nota de Alta, instrumento utilizado na Unidade de Tratamento Intensivo Neonatal, que visava à continuidade do cuidado, não era efetiva para o que se propunha, uma vez que transferia aos pais a tarefa de buscar o acesso à rede. Também foi possível observar que existia um movimento de busca da comunicação entre os níveis primário e terciário de atenção à saúde. Concluiu--se que, apesar da fragilidade observada nas redes de atenção no município, os profissionais da Atenção Básica possuíam a compreensão do que era uma linha de cuidado e já adotavam algumas práticas que procuravam o estabelecimento desta junto a um hospital do município.
Palavras-chave: Acesso aos serviços de saúde. Assistência à saúde. Atenção primária à Saúde. Neonatologia. Sistema Único de Saúde.