bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylactic para-aortic lymph node dissection in Colo-rectal cancer; pilot study
Authors: Abdalwahab Abdalwahab R. , Abdelhamed Mohamed A. , Gad Mai , Allam Rasha Mahmood , Hussien Alaadin 
Published: September 2024

Abstract
Background
Colorectal cancer is the 3rd most common cancer worldwide, representing 10% of all cancer types, and is considered the 2nd leading cause of cancer-related deaths. It usually metastasizes to the liver or lung. Para-aortic lymph node metastasis is considered a metastatic disease (stage 4) according to the AJCC and is considered a regional disease (stage 3) according to the JSCCR. Para-aortic lymph node metastases occur in about 1% of cases. Neoadjuvant CTH, followed by PALN, is the best option for metastatic para-aortic LNs in colorectal cancer patients. This study addresses the value of prophylactic para-aortic LN dissection among colon-rectal cancer patients (overtreatment protocol).

Methodology
This is a prospective study that included patients attending NCI, Cairo University, from December 2020 to December 2023 who were complaining of left colonic cancer or recto-sigmoid cancer and underwent left hemicolectomy, sigmoid colectomy, or LAR. All patients underwent formal mesenteric LN dissection and prophylactic para-aortic LN dissection.

Results
Among 60 patients who underwent colorectal surgery with prophylactic para-aortic LN dissection, 21 cases (35%) were in the descending colon, 22 cases (36.7%) were in the sigmoid colon, 11 cases (18.3%) were in the recto-sigmoid, and 6 cases (10%) were in the upper rectum. 55 cases (91.7%) were in grade 2, and 5 cases (8.3%) were in grade 3. Neoadjuvant CTH was given in 3 cases (5%) while neoadjuvant RTH was given in 6 cases (10%). Regarding reported postoperative complications, lymphorrhea was reported in 2 patients (3.3%) and wound infection occurred in 6 patients (10%). A recurrence was reported among 8 cases (13.4%).

Conclusions
We aimed in this study to highlight the value of prophylactic para-aortic lymph node dissection among colorectal cancer patients (over-treatment protocol) and report its reflection on predicting the behavior of the disease and subsequently selecting the patients who will be suitable to do this procedure.
Experience of a vascular ultrasound-guided program: from the ICU to the hospital
Authors: Oviedo-Torres Miguel Angel , Yepes-Velasco Andrés Felipe , Moreno-Araque Jeimy Lorena , Rodríguez-Lima David Rene , Mora-Salamanca Andrés Felipe 
Published: September 2024

Abstract
Background
The use of peripherally inserted central venous catheters (PICCs) has increased worldwide in the last decade. However, PICCs are associated to catheter-related thrombosis (CRT) and central line-associated bloodstream infections (CLABSIs). We describe the characteristics of patients requiring a PICC, estimate the incidence rate, and identify potential risk factors of PICC-related complications.

Methods
All adult patients requiring a PICC at our institution (Fundación Santa Fe de Bogotá, Bogota, Colombia) from September 2022 to May 2024 were included in the analysis. The database from active PICC monitoring collected demographic and PICC-related information. The incidence rate of CLABSI and CRT, and crude odds ratios (cORs) were estimated.

Results
Overall, 1936 individuals were included in the study. The median age was 67 years (IQR: 50–78 years), and 51.5% were females. The median duration of PICC lines was 10 days (IQR: 4–17). Seventy-nine patients had catheter-related complications, mostly in the Intensive Care Unit (ICU). The CLABSI and CRT institutional incidence rates per 1000 catheter-days were 2.03 (2.96 in the ICU) and 0.58 (0.61 in the ICU), respectively. Prolonged catheter use (≥ 6 days), PICC insertion in the intensive care unit, and postoperative care after cardiac surgery were identified as potential risk factors for CLABSI, while a catheter insertion into the brachial vein was associated with CRT.

Conclusion
Daily PICC assessment, particularly in patients with prolonged catheter use, PICC insertion into the brachial vein, or in postoperative care after cardiac surgery may significantly reduce CLABSI and CRT cases. Implementing Vascular Access Teams, venous catheter care bundles, and institutional insertion protocols optimize clinical outcomes.
Distribution of ABO and D antigen expression in Yogyakarta, Java Island: a pioneer large-scale study in Indonesia
Authors: Bidayah Hasna Fadlilatul , Triyono Teguh , Fichou Yann , Pratiwi Rarastoeti , Nurpratami Diah , Sofro Abdul Salam 
Published: September 2024

Abstract
Objective
Here, we sought to report ABO and D antigen distribution in blood donors from Yogyakarta, Java Island, Indonesia. Phenotype data (ABO/D) from donors who donated blood between January 1, 2018, and December 31, 2023, at the Yogyakarta Blood Donor Unit were extracted from the blood donor registry, and phenotype frequency was calculated subsequently.

Results
In the 245,307 blood donors collected over six years, ABO phenotype frequency: O (frequency: 38.5%) > B (29.4%) > A (24.1%) > AB (8.0%). The D-positive phenotype was far more common (99.5%) than the D-negative phenotype (0.5%). The phenotypic pattern globally is similar to previous reports in Southeast Asia. The D antigen distribution is similar to world distribution as the most common blood group. For the first time in Indonesia, this distribution of ABO and D phenotype is reported in a large-scale study. This work is a pioneer in the coordinated optimization of transfusion guidelines at the national level.
Severe exacerbation of facial dermatitis with swelling following introduction of abrocitinib in a patient with atopic dermatitis
Authors: Chen Shirui , Yang Chongtu , Lu Yonghong 
Published: September 2024

Abstract
Background
Abrocitinib, an oral small-molecule Janus kinase 1 (JAK1) inhibitor, has been widely accepted for the treatment of moderate-to-severe atopic dermatitis (AD). Currently there is a paucity of data on the adverse events (AEs) after abrocitinib treatment, especially on rare events such as exacerbation of facial dermatitis, and their causal relationship and subsequent management remains poorly elucidated.

Case presentation
A 43-year-old female patient with moderate AD received dupilumab after failure of topical treatments. Facial dermatitis persisted and became refractory after dupilumab treatment, and the patient changed treatment to oral abrocitinib. Fifteen hours after the first dose of abrocitinib, she developed exacerbation of facial dermatitis with swelling. The patient was initially diagnosed as abrocitinib-induced hypersensitivity. However, a score of 3 of the Naranjo adverse drug reaction assessment indicates week correlation between abrocitinib therapy and exacerbation of facial dermatitis, and negative results from subsequent drug provocation test further suggests no causal relationship.

Conclusions
The present case report highlights the necessity of careful determination of abrocitinib-induced hypersensitivity, which should not be diagnosed simply based on the time sequence between drug exposure and symptom occurrence. In addition, caution should be exercised for drug withdrawal, especially when confirmative evidence is absent. Drug provocation test can be helpful and effective treatments could be continued unless severe AEs occur.
Diagnostic performance of new BAST score versus FIB-4 index in predicating of the liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease
Authors: Helal Eman , Elgebaly Fatma , Mousa Nasser , Elbaz Sherif , Abdelsalam Mostafa , Abdelkader Eman , El-Sehrawy Amr , El-wakeel Niveen , El-Emam Ola , Hashem Manal , Elmetwalli Alaa , Mansour Shimaa 
Published: September 2024

Abstract
Background and aim
Metabolic dysfunction-associated steatotic liver disease (MASLD) formerly known as non-alcoholic fatty liver disease (NAFLD) is the most common liver condition globally. The FIB-4 test is used to detect fibrosis in fatty liver disease but has limited accuracy in predicting liver stiffness, resulting in high rates of false positives and negatives. The new BAST scoring system, incorporating waist circumference, AST, and BMI, has been developed to assess the presence of fibrosis in NAFLD patients. This study compares the effectiveness of BAST and FIB-4 in predicting liver fibrosis in MASLD patients.

Patients and methods
The study included 140 non-diabetic MASLD patients who underwent transient elastography measurement. BAST score and FIB-4 were calculated for each patient. Patients were grouped based on fibrosis severity; F1, F2, and F3–F4. The sensitivity and specificity of the BAST score and FIB-4 were assessed using receiver operating characteristic curves.

Results
The BAST score increased significantly with fibrosis progression from F1 to F3–F4. In differentiating advanced fibrosis (F2–F3) from mild/moderate fibrosis (F1–F2), the BAST score at cutoff ≤ − 0.451 showed better diagnostic performance with 90.70% sensitivity, 74.07% specificity, 84.8% PPV and 83.3% NPV compared to FIB-4 that had 60.47% sensitivity, 50.0% specificity, 65.8% PPV and 44.3% NPV. Similarly, for differentiating between F1 and F2 fibrosis, the BAST score at cutoff ≤ − 1.11 outperformed FIB-4, with 80.23% sensitivity, 79.49% specificity, 89.6% PPV and 64.6% NPV, while FIB-4 had 59.30% sensitivity, 51.28% specificity, 72.9% PPV and 36% NPV.

Conclusions
The BAST score is a better predictor of liver fibrosis in MASLD compared to FIB-4, especially in cases of advanced fibrosis or cirrhosis.
Advocacy through storytelling: challenging eating disorders and eating disorders stigma
Authors: Habibagahi Kiana , Ferrari Michel 
Published: September 2024

Abstract
Background
Although eating disorders (EDs) are among the most stigmatised mental illnesses, a number of individuals break past this stigma and engage in ED advocacy by sharing their recovery stories. Little is known, however, about the role of such advocacy in their healing journeys.

Methods
To bridge this gap, the authors examined the role of autobiographical oral storytelling in the ED recovery of adult advocates. Autobiographical oral history interviews were carried out with adult advocates (n = 16) recovering from EDs. The data were analysed using a mixture of actantial and thematic analyses. Authors also used activity theory to categorise how storytelling was translated into concrete social actions. Results were then interpreted through frameworks of embodiment and the intersectionality of identity.

Results
Advocates chose to share their ED stories as a way to embody resilience and make meaning from their ED experiences. Beyond personal gains, the social benefits of sharing their stories included raising hope and openness to converse further with audiences, advocating for greater ED resources (e.g., ED literacy among school staff), and offering new training initiatives for healthcare professionals. The ties between storytelling and the unique aspects of one’s identity are also discussed.

Conclusions
Engaging in advocacy through storytelling can positively affect both the advocates and the audiences with whom they connect. Future studies, informed by feminist biopsychosocial frameworks, can examine storytelling as a therapeutic intervention. Such frameworks serve as alternatives to biomedical models of EDs and mental illnesses. They also emphasise the need for broader changes that destabilise oppressive body cultures and display how storytelling can help mobilise change.
Greener solutions for biodeterioration of organic-media cultural heritage: where are we?
Authors: Paolino Benedetta , Sorrentino Maria Cristina , Pacifico Severina 
Published: September 2024

Abstract
Eco-friendly decontamination treatments on works of art made from organic materials are of growing interest. The high risks to human health and the environment associated with traditional biocides (e.g. ecotoxicity, development of biotic resistance) have made it necessary to search for safer alternatives, also looking at the past but innovating it. The current state of the art is explored here, delving into the literature on the topic from 2000 to today, and outlining trends in terms of the most tested artistic supports and types of published research (in vitro/in vivo). An overview of the characteristics and mechanisms of biodegradation processes on different types of organic products and on the microorganisms mainly involved is thus provided. The main chemical-physical action techniques tested are illustrated and their practical-applicative aspects are discussed on the basis of evidence from case studies. Taking stock of the actual situation, literature consultation highlights that if on the one hand research is advancing rapidly towards the discovery of new ecological and safe solutions, on the other hand these are often biocidal treatments whose protocols have yet to be explored and validated.
Cellulose acetate electrophoretic separation of serum and urine proteins in Nigerian children with autism spectrum disorders
Authors: Adewole Mudathir A. , Omotosho Ishiaq O. , Olanrewaju Ayodeji O. , Adeniyi Yetunde C. 
Published: September 2024

Abstract
Background
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by social communication challenges and restricted, repetitive behaviors. While genetic and environmental factors are known to contribute to ASD, the role of the immune system remains unclear. This study investigated the separation patterns of serum and urine proteins in Nigerian children with ASD compared to typically developing children and children with other NDDs.

Methods
Forty-seven participants aged 3–8 years were recruited, including 16 children diagnosed with ASD and 16 children with other NDDs, both according to DSM-5 criteria, along with 15 neurotypical children. Blood and urine samples were collected for protein analysis. Total protein and albumin levels were measured in both serum and urine using established methods. Protein separation in serum and urine was performed using cellulose acetate electrophoresis, followed by densitometry analysis of the electrophoretic patterns.

Results
The results revealed no significant differences in total serum protein levels and most protein fractions between the groups. However, children with other NDDs exhibited significantly lower levels of alpha-2 globulin compared to neurotypical children. Conversely, both ASD and NDD groups showed significantly higher gamma globulin levels compared to the control group. Interestingly, spot urine protein levels were significantly higher in children with ASD compared to neurotypical children.

Conclusion
The observed changes in alpha-2 and gamma globulin levels suggest potential immune system involvement in ASD and other NDDs. The higher urine protein excretion in the ASD group warrants further investigation to explore the potential of urinary protein biomarkers for ASD diagnosis.
Rifaximin alone vs combination with norfloxacin for secondary prophylaxis of spontaneous bacterial peritonitis with hepatic encephalopathy: randomized controlled trial
Authors: Gupta Tarana , Gaur Vaibhav , Saini Anjali , Jarpula Nikhil Sai , Goyal Sandeep Kumar 
Published: September 2024

Abstract
Background
In liver cirrhosis, events of spontaneous bacterial peritonitis (SBP) and hepatic encephalopathy (HE) portend a poor prognosis. Gut dysbiosis remains a common pathogenetic mechanism for both SBP and HE. Recent data suggests the role of rifaximin in gut modulation and improving intestinal dysbiosis. Due to emergence of multidrug-resistant organisms, gut-selective antibiotics with minimal systemic effects are warranted for secondary prophylaxis in patients of cirrhosis. We compared rifaximin alone vs combination with norfloxacin for secondary prophylaxis of patients of cirrhosis presenting with SBP and HE. This was a prospective, open-label, RCT which included all patients of cirrhosis with SBP and HE on admission. On discharge, in addition to standard medical treatment, patients were randomized to rifaximin 400 mg three times a day (group I) and rifaximin 400 mg three times a day with norfloxacin 400 mg once a day (group II) as a secondary prophylaxis of SBP. Primary outcomes were recurrent episodes of SBP and HE at 6 months and 28-day, 90-day, and 6-month mortalities. Secondary outcomes included number of rehospitalizations, episodes of upper gastrointestinal bleed, new acute kidney injury episodes, and change in Child–Turcotte–Pugh (CTP) and model for end-stage liver disease (MELD) scores over next 6 months.

Results
After screening 87 patients of cirrhosis with SBP and HE, 12 patients had in-hospital mortality and another 25 were excluded, one patient was lost to follow-up, and, finally, 49 patients were randomized into group I (n = 24) and group II (n = 25). The HE was grade 2 (18 vs 16) and grade 3 (6 vs 9) in groups I and II respectively. Primary outcomes as recurrent SBP (3 vs 2; P = 0.67); recurrent HE at 6 months (5 vs 2; P = 0.24); and 28-day (2 vs 2; P = 1.0) and 90-day mortality (4 vs 3; P = 0.72) and 6-month mortality (6 vs 8, P = 0.52) were comparable between two groups respectively. Secondary outcomes as number of rehospitalizations (3 vs 8, P = 0.07), new episodes of UGI bleed (2 vs 3, P = 0.1), new AKI episodes (4 vs 1, P = 0.06), ∆CTP (− 4 vs − 4), and ∆MELD (− 9 vs − 8) over the next 6 months were not significantly different between two groups respectively.

Conclusions
Rifaximin was effective in secondary prevention of both SBP and HE in patients of cirrhosis.

Trial registration
The randomized controlled trial was registered in CTRI/2021/09/036321 dated September 7, 2021.
Exploring the potential of small molecules of dual c-Met and VEGFR inhibitors for advances and future drug discovery in cancer therapy
Authors: Dhawale Sachin A. , Deokar Arundhati V. , Firdous Momin Aaliya , Pandit Madhuri , Chaudhari Minal Y. , Salve Sameer B. , Khandgaonkar Madhuri , Parwe Mahesh , Khalse Rupesh , Dake Shruti G. , Chatse Siddharth H. , Tapadiya Ganesh G. 
Published: September 2024

Abstract
Background
Cancer is uncontrolled cell proliferation that has the potential to invade other tissues and cells. The first three most prevalent cancers are breast, lung, and colon cancer. The widest family of kinase enzymes is receptor tyrosine kinases (RTKs) which are aimed by several chemotherapy medicines. The vascular endothelial growth factor (VEGFR), a well-known type IV tyrosine kinase receptor, is an effective biological target for the development of angiogenesis-related cancer treatments. The hepatocyte growth factor (also known as mesenchymal–epithelial transition factor) triggers the activation of the c-Met tyrosine kinase receptor, which controls several biological processes including cell division, survival, and proliferation.

Main body
In this review, we summarized the various dual inhibitors of VEGFR and c-MET receptors which are active for therapeutic action against cancer. Combination of some VEGFR and c-Met inhibitors also shows synergistic action. The developed dual inhibitors of VEGFR and c-MET such as quinolones and quinazolines derivatives, pyridine and pyrimidine derivatives, oxindole moiety and triazine derivatives are most potent for the same. Dual inhibitors of VEGFR and c-MET hold significant promise in improving cancer therapy by enhancing treatment efficacy, reducing resistance, and potentially improving patient outcomes. Clinical trials are currently being conducted on a few of them and other compounds are being under investigation. Inhibiting VEGFR and c-Met pathway activity will be discussed as novel therapeutic strategies for advanced development in treating cancer. The research progress in this review is fetched up to the current year.

Conclusion
Apart from the development of cancer treatment still cancer is listed as a deadly disease, due to its toxicity and resistance to treatment. Hence, the novel approach is necessary to overcome the cancer. The VEGFR and c-MET inhibitors as dual inhibitors may be more significant in future clinical anticancer treatments.
Unmanned aerial vehicle-based evaluation of pollination performance employing clustering image processing technique
Authors: Grbović Željana , Ivošević Bojana , Franeta Filip , Milovac Željko 
Published: September 2024

Abstract

The global decline of pollinator populations is posing a threat to agricultural productivity, increasingly forcing farmers to introduce pollinators to their fields. Selecting suitable pollinator species is critical for effective crop pollination. This study presents an efficient method for early pollination assessment, utilizing unmanned aerial vehicle (UAV) footage for reliable estimation and timely reactions. Twelve oilseed rape (
Brassica napus var. oleracea
) isolation cages with three pollinator treatments were set up, including the control with no pollinators. The trial employed UAV image acquisition, generating high-resolution RGB orthomosaics. A K-means clustering algorithm was implemented to identify oilseed rape flowers, a direct indicator of pollination performance. The percentage of detected oilseed rape flower coverage within each cage was the primary metric for performance assessment. These initial results demonstrated a negative correlation of 0.92 between estimated flower coverage and expert observations, affirming the efficacy of the proposed methodology. By integrating UAVs and clustering image processing, this research contributes to precision agriculture, offering a robust approach for evaluating pollination performance. The findings underscore the potential of advanced technology to support informed decision-making in agricultural practices, addressing the urgent need for sustainable pollination management in the face of declining pollinator populations.
Prediction of moisture content of cement-stabilized earth blocks using soil characteristics, cement content, and ultrasonic pulse velocity
Authors: Sathiparan Navaratnarajah , Tharuka R. A. N. S. , Jeyananthan Pratheeba 
Published: September 2024

Abstract
This article investigates the importance of moisture content in cement-stabilized earth blocks (CSEBs) and explores methods for their prediction using machine learning. A key aspect of the research is the development of accurate moisture content prediction models. The study compares the performance of various machine learning models, and XGBoost emerges as the most promising model, demonstrating superior accuracy in predicting moisture content based on factors like soil properties, cement content, and ultrasonic pulse velocity (UPV). The study employs SHAP (SHapley Additive exPlanations) to understand how these features influence the model’s predictions. UPV is the most significant factor affecting predicted moisture content, followed by cement content and soil properties like uniformity coefficient. Also, the study explores the possibility of using a reduced set of features for moisture content prediction. They demonstrate that a combination of UPV, cement content, and uniformity coefficient can achieve good accuracy, highlighting the potential for practical applications where obtaining all data points might be challenging.